SGTCid condition conc unit RPA49|YNL248C.score RPA49|YNL248C.strain.pval RPA49|YNL248C.strain.significant RPA49|YNL248C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_422 cantharidin 155 µM 9.63124945926352 1.50136670965979e-20 yes 1 2.95037787396932e-22 5 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2544 sphondin 68.51 µM 9.10425046139472 1.40192651438621e-18 yes 2 4.34320717347158e-20 2 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1915 st067105 30.6 µM 8.47014970091384 2.37344277015634e-16 yes 3 1.22538931028162e-17 3 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2688 kanamycin b 96.69 µM 6.27371666361398 7.95021564205916e-10 yes 4 1.76264891318697e-10 138 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1105 epirubicin 18.1 µM 6.03928735327847 3.07454826121589e-09 yes 5 7.73981815066725e-10 3 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_408 cantharidin 100 µM 6.01139148578295 3.59986101103801e-09 yes 6 9.19688081422722e-10 8 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_118 0083-0097 135.343 µM 5.80138044078161 1.15481184065589e-08 yes 7 3.28855924158189e-09 28 5207356
SGTC_2612 dictamnine 15.46 µM 5.59434938755943 3.50874071801138e-08 yes 8 1.10725304536612e-08 14 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1930 st074634 34.3 µM 5.19814242858767 2.65160186348248e-07 yes 9 1.00644938361031e-07 15 684253 YOR116C RPO31
SGTC_2651 TUB2.036 5 µM 4.56952996712323 4.96021613185868e-06 yes 10 2.44409635461827e-06 131 15992207 YFL037W TUB2
SGTC_202 3594-0513 34.79 µM 4.30489968137099 1.53672208180559e-05 yes 11 8.35307111982662e-06 6 708429
SGTC_3247 9135149 49.47 µM 4.2140621605439 2.2342667718445e-05 yes 12 1.25409103077969e-05 20 8934436 YOR116C RPO31
SGTC_3050 9093513 49.47 µM 4.07774188498027 3.86622792327425e-05 yes 13 2.27376050320995e-05 16 25236664
SGTC_3291 9121177 71.43 µM 4.05055114393046 4.30489358923209e-05 yes 14 2.55485698325357e-05 11 17015612
SGTC_1511 0906-3109 28.5 µM 3.97324904169003 5.82312667971527e-05 yes 15 3.54494260396643e-05 48 2882180
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 3.89647792479309 7.82083756964479e-05 yes 16 4.88008495764448e-05 13 2724278 An inhibitor of dopamine biosynthesis.
SGTC_580 1123-0028 41 µM 3.85487502030548 9.15708264142472e-05 yes 17 5.78943826929887e-05 41 1677248 YPR107C YTH1
SGTC_2556 citropten 84.59 µM 3.78828739394678 0.000117507957144621 yes 18 7.58446605386605e-05 26 2775 A potential DNA crosslinker.
SGTC_3346 9158254 43.5805 µM 3.78818672138802 0.000117551936011253 yes 19 7.58753930165349e-05 21 17639500
SGTC_56 0957-0365 83.25 µM 3.67706585495171 0.000176734797213504 yes 20 0.000117966073312963 59 6752360
SGTC_1187 1391-0724 117 µM 3.66536691716411 0.000184374683377074 yes 21 0.000123492111160243 27 6997986
SGTC_272 doxorubicin 8.13 µM 3.62540695655439 0.000212862129782589 yes 22 0.000144253379870371 30 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_949 1165-0505 146 µM 3.50303654361298 0.000327733526504673 yes 23 0.000229993175905071 31 6244267
SGTC_2140 5586273 200 µM 3.4878497469561 0.000345459255036892 yes 24 0.000243460813147533 14 854421
SGTC_362 0310-0100 9.03 µM 3.48067181000983 0.000354143697691686 yes 25 0.000250078964526477 51 790235
SGTC_72 0744-0168 198.391 µM 3.46119008018254 0.000378747335736227 yes 26 0.000268896472687887 43 677577
SGTC_538 2922-0838 53.3 µM 3.45085980534054 0.000392428575363181 yes 27 0.000279401879864783 50 777039
SGTC_2162 5663267 200 µM 3.37193153752248 0.000513117177481217 yes 28 0.000373215002947092 27 6456493
SGTC_3212 9128307 49.47 µM 3.36028878342116 0.000533582833296674 yes 29 0.000389305201610635 74 27243542
SGTC_2661 dactinomycin 12.96 µM 3.30666456592957 0.000637958447881789 yes 30 0.000472069373422385 42 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2151 5563267 85.4165 µM 3.30027544947481 0.000651578724030377 yes 31 0.000482949877262372 40 5310824
SGTC_2747 doxorubicin 7.63 µM 3.28547291604632 0.000684172151149338 yes 32 0.000509056649668404 11 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_830 4076-0286 57.8 µM 3.26725018482277 0.000726360110122092 yes 33 0.000542988316631793 104 6866659
SGTC_71 0417-1750 47.813 µM 3.23237062478144 0.000813868102482317 yes 34 0.000613838566282467 83 6811472
SGTC_791 1348-1292 225 µM 3.15353912175439 0.00104851283964394 no 35 0.00080651803195447 84 5437054
SGTC_782 0083-0095 30.5 µM 3.12660121233888 0.00114195888341038 no 36 0.000884198111501431 66 3591729 An indicator and reagent.
SGTC_625 k213-0058 121 µM 3.10909589155754 0.00120671006302275 no 37 0.000938304008158918 191 3655420
SGTC_1871 st057448 67.3 µM 3.08480033226199 0.00130215278984605 no 38 0.00101844422497349 62 691747
SGTC_3132 9126706 49.47 µM 3.05072871335055 0.00144764554735037 no 39 0.00114143368966476 62 850858
SGTC_1092 toremifene 6.32 µM 3.04406787886092 0.00147776661606006 no 40 0.00116701235586168 64 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1137 ixabepilone 100 µM 3.03957587534658 0.00149840169088418 no 41 0.00118455758971032 85 154225 A novel microtubule stabilizer.
SGTC_707 0865-0008 204 µM 2.98715795329249 0.00175939814746061 no 42 0.00140792098005055 35 723043
SGTC_2558 carylophyllene oxide 100 µM 2.9709762277144 0.00184795348397051 no 43 0.00148427379120028 53 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2346 9031566 143.75 µM 2.97001010359828 0.0018533666895445 no 44 0.00148894977349891 64 4771086
SGTC_829 1635-0120 117 µM 2.95982159267902 0.00191133699718617 no 45 0.00153908621674874 91 285054
SGTC_2809 7964133 12.99 µM 2.93472335814263 0.00206123353897464 no 46 0.00166922591278505 108 1253665
SGTC_2489 cantharidin 73.42 µM 2.92870591101049 0.00209872214476048 no 47 0.001701881499823 106 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2738 aclarubicin 5.55 µM 2.90365776130367 0.00226150788563631 no 48 0.00184415547690411 32 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_424 splitomicin 100 mM 2.90138489146683 0.00227683097548934 no 49 0.00185758622345325 78 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_622 1348-1566 26.3 µM 2.89642104231585 0.00231062339411351 no 50 0.00188722805582172 68 7340407
SGTC_1862 st057513 3.81 µM 2.85764054692377 0.00259066402209512 no 51 0.00213401786946518 59 5393163
SGTC_1051 3253-3903 78 µM 2.85292518206142 0.00262672744551101 no 52 0.00216594095876787 83 5509239
SGTC_974 1326-0144 138 µM 2.83682635426995 0.00275329514338446 no 53 0.00227821927288423 102 5411856
SGTC_1693 xanthone 101.9 µM 2.82946185204095 0.00281300840636057 no 54 0.00233131791373161 56 7020 An insecticide.
SGTC_1712 st032288 53.4 µM 2.82217986495126 0.00287319889685144 no 55 0.00238492086856901 288 2883011
SGTC_800 3448-7362 155 µM 2.81177793268201 0.0029611927857011 no 56 0.00246342525789754 303 15991913
SGTC_361 000s-0510 1.45 µM 2.80034780419153 0.0030606790058071 no 57 0.00255237864333012 109 660
SGTC_997 3996-0078 137 µM 2.79449768244969 0.00311275351800232 no 58 0.00259902066783549 106 735687
SGTC_1808 st050063 61.5 µM 2.78213519662173 0.00322542974590343 no 59 0.00270012693897832 59 4011993
SGTC_1904 st060225 78 µM 2.77760886906902 0.00326759338460506 no 60 0.00273802459051015 68 66595
SGTC_2843 9000894 45.46 µM 2.77198883437749 0.00332063465335278 no 61 0.00278574738069829 37 2242070
SGTC_832 4083-0019 164 µM 2.75509796997778 0.00348473987669337 no 62 0.00293372817289853 229 1990758
SGTC_1457 k015-0032 57.3 µM 2.75070894627545 0.00352855739192536 no 63 0.00297332266863972 119 4302660
SGTC_273 hydroxyurea 18.1 mM 2.72374745477808 0.00380874748969411 no 64 0.00322729209005923 101 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1402 3909-7673 35.9 µM 2.71532552572793 0.0039002703751105 no 65 0.00331053268861922 75 5328014
SGTC_2787 5284540 71.43 µM 2.71071944314155 0.00395115480023449 no 66 0.00335687032906132 98 736958
SGTC_2908 7930301 100 µM 2.70517845396476 0.00401315469860176 no 67 0.00341338521831093 116 2223178
SGTC_1838 st055369 84.5 µM 2.69203685051121 0.00416369659575643 no 68 0.00355085489461115 74 676036
SGTC_59 0330-0160 1.33 µM 2.68264047421702 0.00427441260700632 no 69 0.00365217341337841 241 4293482
SGTC_3254 9136651 49.47 µM 2.66176371266025 0.00452987178670335 no 70 0.00388662119746476 78 16454030
SGTC_1154 4088-0362 150 µM 2.6286114536478 0.00496361764358706 no 71 0.0042867128012184 123 6618304
SGTC_1671 st016596 74.5 µM 2.59071474760756 0.00550444235921776 no 72 0.00478884218970209 93 2829167
SGTC_750 4073-0104 132 µM 2.58595938974785 0.0055758770311426 no 73 0.00485541855760334 71 22330957
SGTC_1158 4092-0494 91.8 µM 2.57627480815444 0.00572390910239336 no 74 0.00499356181285704 95 1148199
SGTC_1600 coumarin 106 71.1 µM 2.56887330118425 0.00583938475297153 no 75 0.00510148767830261 121 100336 A hepatotoxic, DNA x-linker.
SGTC_1272 0839-0021 27 µM 2.5643346857478 0.00591121252472802 no 76 0.00516869051822591 108 5027250
SGTC_2442 5158906 48.48 µM 2.55978876055845 0.00598394033477107 no 77 0.0052367902087796 104 1893835
SGTC_375 3970-0961 9.27 µM 2.55435383994148 0.00607193102877227 no 78 0.00531925419437402 117 2898222
SGTC_2671 danthron 100 µM 2.53474546860902 0.00639899376207692 no 79 0.00562645283057442 141 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_91 0417-1751 58.384 µM 2.52769533213517 0.00652034380606691 no 80 0.00574069683615971 164 6795624
SGTC_744 1594-0068 283 µM 2.52413248841696 0.00658243978375856 no 81 0.00579921036990896 143 668392
SGTC_2553 4-methylesculetin 85.09 µM 2.5075769392729 0.0068778940285927 no 82 0.00607810568018739 117 5319502
SGTC_2932 9016711 44.54 µM 2.50351457858066 0.00695215756578566 no 83 0.00614833071408784 171 7117328
SGTC_2421 5690543 90.72 µM 2.49492665312638 0.00711148651284822 no 84 0.0062991584288293 112 3397993
SGTC_728 3030-5151 22.5 µM 2.4806466309281 0.00738355843461361 no 85 0.00655721560098552 77 3125388
SGTC_729 4092-0585 94.1 µM 2.48048721828855 0.00738664673937135 no 86 0.00656014838279678 121 2169061
SGTC_3207 9114163 49.47 µM 2.48041126117167 0.00738811865875841 no 87 0.00656154620601446 153 849233
SGTC_1266 0828-0227 32.9 µM 2.47931473109719 0.00740939636045189 no 88 0.00658175479032861 124 3913820
SGTC_914 3820-6779 408 µM 2.4710333606554 0.00757184425532442 no 89 0.00673616250211618 126 2893481
SGTC_3322 9139058 2.11 µM 2.46887548962421 0.00761468496348779 no 90 0.00677691847513895 132 4908926 YPR165W RHO1
SGTC_2178 5812956 200 µM 2.46549739917184 0.00768217958456223 no 91 0.00684115842465391 110 5403383
SGTC_756 0508-1999 28.3 µM 2.44809947662081 0.00803819828735388 no 92 0.0071805999787686 111 6753853
SGTC_159 3970-0959 50 µM 2.43640451507101 0.00828559270407354 no 93 0.00741704264311953 272 6615653
SGTC_1014 4130-3005 69.3 µM 2.43351774557358 0.00834767876179217 no 94 0.00747645122310372 141 743608
SGTC_1214 0358-0031 63.7 µM 2.40319316396754 0.00902495999230569 no 95 0.00812629994910199 134 4301366
SGTC_163 TUB2.036 7.546 µM 2.40183660828279 0.0090563515585403 no 96 0.00815649648236729 295 15992207 YJR013W GPI14
SGTC_2270 7924575 90.91 µM 2.38743773288558 0.00939548955803723 no 97 0.00848313828299466 127 1262135
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.37742827955212 0.00963774026362908 no 98 0.00871691646624587 208 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1201 1889-3372 45.9 µM 2.37487971955241 0.00970028614680203 no 99 0.00877733479904395 93 5392199
SGTC_1897 st060201 15 µM 2.36477131303472 0.00995186935847422 no 100 0.00902060367469461 125 611878
SGTC_822 1487-0950 154 µM 2.33908428682824 0.0106169674222958 no 101 0.00966553586650565 128 1958375
SGTC_961 1252-1571 372 µM 2.33823253434949 0.0106396692306188 no 102 0.00968759432178799 158 6813498
SGTC_1727 st034309 9.9045 µM 2.33163087745997 0.010817061831492 no 103 0.00986005900073619 213 870305
SGTC_737 1950-0117 57.9 µM 2.32696823636157 0.0109438974949568 no 104 0.00998347794127856 141 5393513
SGTC_87 0100-0052 35.5 µM 2.32590484409901 0.0109730050222464 no 105 0.0100118137834673 346 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2814 7977482 42.97 µM 2.30917174263199 0.0114399766604908 no 106 0.0104670264685338 213 6456762
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.30037779189206 0.0116922403673712 no 107 0.0107134129448777 185 65057 A dermal irritant. YDR527W RBA50
SGTC_3144 9087057 49.47 µM 2.2988235329589 0.0117373244887267 no 108 0.0107574809686892 138 17249618
SGTC_283 0987-0079 11.7 µM 2.28473842035684 0.0121528142597763 no 109 0.0111640851841521 179 411556
SGTC_919 tnp00227 403.569 nM 2.27939411136799 0.0123137674188271 no 110 0.0113218240293158 178 1269246 A methoxyflavone. YNL221C POP1
SGTC_608 k048-0125 159 µM 2.27780615967289 0.0123619458439839 no 111 0.0113690645891012 140 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_511 blebbistatin 171 µM 2.26295701103843 0.0128204269257028 no 112 0.0118191697184483 146 3476986 A myosin inhibitor.
SGTC_670 4204-0025 119 µM 2.26015748346531 0.0129084935134028 no 113 0.0119057392719189 173 719039
SGTC_1195 1502-0147 41.1 µM 2.25219831441086 0.0131617339453046 no 114 0.0121548712505384 179 817940
SGTC_3011 9081274 71.4286 µM 2.25212988159222 0.0131639297858817 no 115 0.0121570327289119 173 6625322
SGTC_432 NS 1619 61.3 µM 2.23758247757712 0.0136379648573735 no 116 0.0126241476399038 172 4552 A K+/calcium channel activator.
SGTC_2968 9090663 33.37 µM 2.21914753787937 0.0142597796979048 no 117 0.0132383444135453 179 25236811
SGTC_2451 5856223 45.7 µM 2.20893823878143 0.014614535717871 no 118 0.0135894685117564 163 2179896
SGTC_1802 st050112 57.9 µM 2.20745399568431 0.0146667377920667 no 119 0.0136411788123211 147 4662563
SGTC_1692 fluoroquinolonic acid 71 µM 2.20726435814251 0.0146734190473456 no 120 0.0136477979081583 114 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2937 9044753 11.33 µM 2.20424990144899 0.0147799756665249 no 121 0.0137533870522955 222 6465530 YGL099W LSG1
SGTC_1666 st014829 29 µM 2.20408450769419 0.014785841303196 no 122 0.013759200733464 182 3858230
SGTC_2358 9037157 4 µM 2.19935466499211 0.014954433020734 no 123 0.0139263567672731 188 2388925
SGTC_2290 7904846 200 µM 2.19072553385062 0.0152662717811979 no 124 0.0142358300901375 205 2962154
SGTC_2185 6113692 200 µM 2.1899987284044 0.0152927902053799 no 125 0.014262164521166 145 874150
SGTC_2083 5306046 65.942 µM 2.18558176418194 0.0154548010374835 no 126 0.0144231089874362 207 539837
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.16617985083254 0.0161840131378379 no 127 0.0151487231094415 170 688669
SGTC_695 3505-6186 243 µM 2.16274712787897 0.0163160532898116 no 128 0.0152803170886134 171 1819379
SGTC_2077 5212015 200 µM 2.1605032060355 0.0164028638224016 no 129 0.0153668678425882 214 780900
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.1590441382461 0.0164595226628861 no 130 0.0154233714025749 199 4174840
SGTC_673 1082-0474 110 µM 2.1567422762586 0.0165492497276053 no 131 0.0155128754960409 264 3098046
SGTC_2801 7907800 81.82 µM 2.15394292193812 0.0166589330057857 no 132 0.0156223241873705 196 6620925
SGTC_1525 8-methoxypsoralen 92.5 µM 2.15318348679504 0.0166887959610984 no 133 0.0156521304712813 196 4114 Related to psoralen; DNA damaging agent.
SGTC_3352 9151559 45.5865 µM 2.13062956295819 0.0175967870503492 no 134 0.0165598360388409 171 17159339
SGTC_902 1120-0002 2.07 µM 2.12307192055073 0.0179103330511461 no 135 0.0168739127889665 230 3280475
SGTC_33 0986-0033 35.816 µM 2.12188063347495 0.0179601884704503 no 136 0.0169238815723796 149 2848082
SGTC_3269 9137823 49.47 µM 2.12162239867784 0.0179710112013891 no 137 0.0169347299546129 167 17682936
SGTC_1164 k060-0068 93.7 µM 2.12104273138397 0.0179953255596954 no 138 0.0169591032942659 206 5963676
SGTC_1627 st003713 25.6 µM 2.11757111218122 0.0181415316903284 no 139 0.0171057034275893 308 16195070 YER133W GLC7
SGTC_468 gf-109203x 121 µM 2.11644504002195 0.0181891728030029 no 140 0.0171534874318631 92 2396 A protein kinase C inhibitor.
SGTC_2110 5483698 200 µM 2.11316546041034 0.0183285309578548 no 141 0.0172933042222862 176 2848765 YHR062C RPP1
SGTC_179 1273-0063 6.77 µM 2.0943681004509 0.0191449481112516 no 142 0.018113601066811 164 3108139
SGTC_1365 1672-3266 55.4 µM 2.0697159267077 0.0202623435807283 no 143 0.0192394771989853 197 6415873
SGTC_1839 st053978 48 µM 2.06557082894806 0.0204555540342961 no 144 0.0194345106124161 201 3788398
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.06303583506019 0.0205744822600088 no 145 0.0195546118125363 172 756377
SGTC_1144 3486-0183 12.5 µM 2.06172853881469 0.0206360421260368 no 146 0.0196167939577804 231 6744069
SGTC_3155 9099265 49.47 µM 2.0602708649405 0.0207048670845185 no 147 0.0196863267920161 192 25236499
SGTC_31 0508-1974 57.237 µM 2.06016574013801 0.0207098381223919 no 148 0.0196913494535574 186 6810525
SGTC_606 k015-0008 38.6 µM 2.04936069036967 0.0212261955299231 no 149 0.0202134290605416 221 1970475
SGTC_269 exalamide 29 µM 2.04162677588907 0.0216024388319538 no 150 0.0205942835978927 162 3316 A derivative of salicylamide.
SGTC_1704 st028805 70.8 µM 2.03128731123893 0.0221142285917893 no 151 0.0211129288939047 178 2876101
SGTC_1357 1503-1303 39.5 µM 2.00575166481287 0.0234222142056822 no 152 0.022441374984413 248 292895
SGTC_130 0136-0219 337.655 µM 1.98755079361248 0.0243937288780866 no 153 0.0234306964940769 227 234244
SGTC_1296 1068-0102 11.9 µM 1.98718023992618 0.0244138542596241 no 154 0.023451213394791 202 767053
SGTC_3049 9092223 49.47 µM 1.97380461428657 0.0251496939056671 no 155 0.024201981987151 198 8623917
SGTC_3094 9117742 49.47 µM 1.96898264873 0.0254194854613024 no 156 0.0244775418116153 265 17149698
SGTC_994 3910-0338 138 µM 1.96889576657939 0.0254243687099962 no 157 0.0244825309003539 266 3479481
SGTC_1821 st053465 65.6 µM 1.967826262779 0.0254845450263742 no 158 0.024544015648331 181 675086
SGTC_321 4534-3890 65.3 µM 1.95606819848514 0.0261540194611139 no 159 0.0252285603983429 180 699746
SGTC_1721 st082152 9.2685 µM 1.95057953102558 0.0264715293621314 no 160 0.0255535420499647 223 5296051
SGTC_731 3966-0296 387 µM 1.94904806367554 0.0265606946758113 no 161 0.0256448425647092 227 660956
SGTC_1911 st060208 74.3 µM 1.9483951916382 0.0265987824985747 no 162 0.0256838473631033 250 688783
SGTC_2024 5144227 134 µM 1.94790556028008 0.0266273769743646 no 163 0.0257131321841461 265 3475211
SGTC_7 0192-1582 4.227 µM 1.94382158293137 0.0268668830310073 no 164 0.0259584850679905 326 252616
SGTC_333 3486-0131 40.1 µM 1.93357241391776 0.027475879357896 no 165 0.0265828608639065 228 6744690
SGTC_111 0083-0039 52.457 µM 1.93014101151694 0.0276823245651906 no 166 0.0267946840603631 112 759313
SGTC_3318 9139014 38.6185 µM 1.9269093391115 0.0278779337906568 no 167 0.0269954647124365 215 16643984
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.92220858264658 0.0281645193713851 no 168 0.0272897586584162 309 368090
SGTC_873 0591-4978 488 µM 1.91970943064207 0.028317878219544 no 169 0.0274473061850854 239 3305145
SGTC_2622 2-methoxyxanthone 59.94 µM 1.9179847303305 0.028424118130628 no 170 0.0275564736765748 223 71034 A hepatoprotective.
SGTC_2783 7738165 71.43 µM 1.91568413120653 0.0285663489053841 no 171 0.0277026567546741 204 17201110
SGTC_2455 5377712 9.75 µM 1.90471694390335 0.0292525388367901 no 172 0.0284084376313839 223 2243908
SGTC_2087 5276107 200 µM 1.90427890809198 0.0292802275433054 no 173 0.0284369348354891 239 144405
SGTC_2434 5670830 169.91 µM 1.90019185732152 0.0295396248365241 no 174 0.0287039732358326 279 1549830
SGTC_1487 3970-0795 2.82 µM 1.89937331863321 0.0295918045258934 no 175 0.0287577045123179 245 3765103
SGTC_2176 5809774 33.9695 µM 1.87836281846603 0.0309575711897724 no 176 0.0301657741661579 227 2870539
SGTC_2985 9022375 71.43 µM 1.87549878284854 0.0311477227726794 no 177 0.0303620683904736 264 4939335
SGTC_3287 9117173 37.0625 µM 1.86432242880867 0.0318990174604474 no 178 0.0311382194786321 161 2789709
SGTC_1027 k015-0025 8.67 µM 1.86382830176577 0.0319325761013941 no 179 0.031172909971346 266 3598955
SGTC_2634 4'-methoxyflavone 100 µM 1.85961274636612 0.0322200626630718 no 180 0.0314701673228725 264 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_403 arphamenine a 50 µM 1.8562926647714 0.0324479818511273 no 181 0.0317059270316623 264 5487158 An arginine aminopeptidase inhibitor.
SGTC_931 2812-0076 566 µM 1.84310001566015 0.0333668206113626 no 182 0.0326572045321597 274 3450959
SGTC_3002 9075603 71.4286 µM 1.84160805645002 0.0334720676860536 no 183 0.0327662508725531 270 20105405
SGTC_2247 cerulenin 830 nM 1.84047184238556 0.0335524026746853 no 184 0.0328494972460408 267 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_889 0919-1524 82.7 µM 1.83776269078684 0.0337445912804046 no 185 0.033048690770498 253 3905452
SGTC_84 0443-0269 128.823 µM 1.83648777451974 0.0338353474284734 no 186 0.0331427742859423 281 6150058
SGTC_2154 5570129 200 µM 1.83433309173307 0.0339891870115294 no 187 0.0333022824312911 286 673366
SGTC_2496 diffractaic acid 79.83 µM 1.82893655406464 0.0343770136855018 no 188 0.03370455670001 286 94870 An apoptosis inducer which activates caspases.
SGTC_188 3229-0966 278.469 µM 1.82326639863463 0.0347884142912599 no 189 0.0341315264221547 334 5722370
SGTC_840 0245-0196 390 µM 1.81817415015231 0.0351613218613446 no 190 0.034518759804468 308 3827528
SGTC_629 3448-6466 76.7 µM 1.81778048374003 0.0351902862749948 no 191 0.0345488453427494 295 573744
SGTC_1194 1488-0194 225 µM 1.81528412355629 0.0353744145031049 no 192 0.0347401287780103 318 1391452
SGTC_168 3970-0862 530.542 µM 1.8109818172775 0.0356936007439067 no 193 0.035071833157348 514 3135186
SGTC_3166 9102297 49.47 µM 1.80245166401907 0.0363334288481399 no 194 0.03573718650428 313 25237072
SGTC_2972 9093619 59.92 µM 1.79485301940253 0.0369112641411433 no 195 0.0363385604166121 290 25236256
SGTC_1654 st012436 41.8 µM 1.79364988649349 0.0370034411022829 no 196 0.036434534352521 239 4323132
SGTC_1825 st052143 62.6 µM 1.78081377940271 0.0379986282437444 no 197 0.0374714388024507 241 674173
SGTC_356 1634-0012 32.5 µM 1.77763284608712 0.0382485939228152 no 198 0.0377320877594574 318 735457
SGTC_2248 tofa 1.1 µM 1.77319682957943 0.0385994242966691 no 199 0.0380980486158443 264 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1242 0402-0103 60.1 µM 1.75746431908903 0.0398648535962756 no 200 0.0394193492462974 279 432868
SGTC_1514 1189-1591 158 µM 1.7559574091323 0.0399878099863853 no 201 0.0395478405955342 371 767698 YMR146C TIF34
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.74873600669433 0.0405813245356264 no 202 0.0401683314901721 292 75037 A free radical scavenger.
SGTC_1196 1588-0294 184 µM 1.74768418029835 0.0406683659070593 no 203 0.0402593648155965 278 6144269
SGTC_2099 5377090 177.372 µM 1.73337665786039 0.0418674660908841 no 204 0.0415143718154408 328 2243829
SGTC_2258 7960471 200 µM 1.73190466012724 0.0419924404106982 no 205 0.0416452694471332 229 2974708
SGTC_2707 st078556 66.6 µM 1.72419332067184 0.0426520853108776 no 206 0.0423364747658352 280 17250899
SGTC_1085 doxorubicin 7.67 µM 1.72130731623593 0.0429011046793835 no 207 0.0425975362878926 358 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2870 9038528 12.99 µM 1.7201984280412 0.0429970971674971 no 208 0.0426981893434377 286 6463316
SGTC_3138 9097216 49.47 µM 1.71725235753294 0.0432529711349195 no 209 0.0429665364230569 298 25237486
SGTC_979 1426-2828 121 µM 1.70772779601501 0.0440886285265328 no 210 0.0438434310245244 361 747872
SGTC_52 0329-0193 875 nM 1.70632383030448 0.0442129019968321 no 211 0.0439739017952 332 3739292
SGTC_1268 0828-0275 2.46 µM 1.70513891766933 0.0443180053408131 no 212 0.04408425941082 309 745337
SGTC_1217 1183-1422 255 µM 1.70301035092738 0.0445073177733297 no 213 0.0442830656718198 309 2849664
SGTC_164 4100-3994 89.624 µM 1.69848624274379 0.0449118510383417 no 214 0.0447080135179474 397 4615967
SGTC_2502 avocadyne acetate 18.59 µM 1.69784957509206 0.044969016943891 no 215 0.0447680782083478 398 3952079
SGTC_2881 9058953 51.95 µM 1.69320225638267 0.045388072334236 no 216 0.0452084876304759 365 17122249
SGTC_881 0833-0569 170 µM 1.69130531133696 0.0455600227544205 no 217 0.0453892530764328 352 5418700
SGTC_1752 st044819 83.042 µM 1.68763293976954 0.0458943967530217 no 218 0.0457408560003083 330 441209 YML126C ERG13
SGTC_2806 7952793 58.44 µM 1.68647216815537 0.0460004956534946 no 219 0.0458524456898563 334 2972490
SGTC_2411 st077133 39.94 µM 1.6847337316973 0.046159763752952 no 220 0.0460199777014798 394 1403142 YNL221C POP1
SGTC_884 0851-0618 334 µM 1.68402997912183 0.0462243643497208 no 221 0.0460879375607737 366 9642473
SGTC_3338 9144300 39.5675 µM 1.66733228091297 0.0477785289200081 no 222 0.0477241755905133 337 4901274
SGTC_2947 9072639 7.68 µM 1.66444651046075 0.0480513191993101 no 223 0.0480116159924716 397 16488146
SGTC_2066 5222451 176 µM 1.65887209504032 0.0485817942004187 no 224 0.0485707843820003 409 2281147
SGTC_2944 9067346 25.62 µM 1.65491949929247 0.0489607621035509 no 225 0.0489704141565969 375 6473075
SGTC_265 mycophenolic acid 32.932 µM 1.65108197496732 0.049330953256731 no 226 0.0493609186757768 365 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2405 ticlatone 3.52 µM 1.64608869938904 0.0498159771197876 no 227 0.0498727493450772 374 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1445 4239-0156 97.7 µM 1.64557833409957 0.0498657651963531 no 228 0.0499253014013353 394 4008346
SGTC_3282 9108498 15.4605 µM 1.6381784816204 0.0505921177640231 no 229 0.05069223354407 371 16459645
SGTC_8 0354-0001 70 µM 1.63572788312969 0.0508345120678588 no 230 0.0509482755667402 462 4993152
SGTC_1259 0671-0132 43 µM 1.63410763511345 0.0509952816545652 no 231 0.0511181259792364 372 X1259
SGTC_546 peri-Naphthalide 147 µM 1.62753159673683 0.0516519495935829 no 232 0.0518121217870087 346 223824 A penicillin ester.
SGTC_1315 1237-0019 3.69 µM 1.62751893439253 0.0516532204799033 no 233 0.0518134652825024 345 825140
SGTC_3231 9132313 49.47 µM 1.62536331504502 0.0518699369410416 no 234 0.0520425838841812 340 4905967
SGTC_2439 5492030 7.2 µM 1.62249794962228 0.052159126042716 no 235 0.0523483858878712 330 5722370
SGTC_1612 st002233 45.4 µM 1.62126455075162 0.0522840013292942 no 236 0.052480457081414 360 1035021
SGTC_789 1309-1135 70.6 µM 1.6150802591678 0.052913712310176 no 237 0.0531466576773814 408 3092424
SGTC_1171 0368-0077 21.4 µM 1.6097079169827 0.0534656165615646 no 238 0.0537308178985905 326 3239779
SGTC_1254 0550-0035 264 µM 1.60926047423586 0.0535117876571904 no 239 0.0537796989772252 395 15121435
SGTC_3314 9135860 59.4275 µM 1.60730741740302 0.0537136913150488 no 240 0.0539934739910038 359 25252478
SGTC_1050 3232-1156 69.3 µM 1.60457168280149 0.0539975208057819 no 241 0.0542940486918503 368 700529
SGTC_1781 st038725 66.3 µM 1.5968610307221 0.0548038842786662 no 242 0.0551483440173003 484 4270275 YIL048W NEO1
SGTC_633 0437-0093 97.7 µM 1.59322830039628 0.0551870716260341 no 243 0.0555544923213106 346 2831118
SGTC_2862 9027634 71.43 µM 1.58592500134056 0.0559638396746431 no 244 0.0563781618119662 358 5012562
SGTC_854 0422-0053 192 µM 1.58495335024916 0.05606782988379 no 245 0.0564884668517503 370 3596728
SGTC_2775 cyproheptadine 69.59 µM 1.58004762228531 0.0565951905170436 no 246 0.0570479804626333 365 2913 A selective serotonin reuptake inhibitor.
SGTC_3217 9129673 49.47 µM 1.57825652040069 0.0567887031802676 no 247 0.0572533451418403 388 17248312
SGTC_2321 7390090 138.78 µM 1.57767049485074 0.0568521310685063 no 248 0.0573206640036253 332 649046
SGTC_3236 9132701 49.47 µM 1.5770816048375 0.0569159251773851 no 249 0.057388374642741 360 24282524
SGTC_378 3970-0959 8.33 µM 1.5759225424229 0.0570416503711924 no 250 0.0575218275752045 373 6615653
SGTC_2571 chrysanthemic acid 100 µM 1.57475940664246 0.0571680371027493 no 251 0.057655994784574 356 2743 An insecticide.
SGTC_930 2810-3379 265 µM 1.5719154575248 0.0574779899311428 no 252 0.0579850796035745 438 1015764
SGTC_2986 9022445 71.43 µM 1.56930598160426 0.0577635498349372 no 253 0.0582883296042907 379 6459286
SGTC_1804 st050076 49.1 µM 1.56634978274008 0.0580883986225375 no 254 0.0586333761828486 383 3895976
SGTC_3137 9097352 49.47 µM 1.56441983205205 0.0583012490960083 no 255 0.0588595031460511 424 44120435
SGTC_2794 7785382 27.27 µM 1.56257539769783 0.0585052401948644 no 256 0.0590762493716905 481 2205081
SGTC_1769 st044406 64.4 µM 1.55952897339662 0.0588433960062755 no 257 0.0594356162748732 421 670903
SGTC_1129 3453-1384 223 µM 1.55564845984091 0.059276355407103 no 258 0.0598958543177154 436 1084452
SGTC_784 4579-0127 173 µM 1.55147463814488 0.0597448240875052 no 259 0.0603939903109577 410 1948547
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.54830550050347 0.0601024607976464 no 260 0.0607743803833507 461 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3 0833-0587 95.581 µM 1.54498115343882 0.0604794119678283 no 261 0.0611754110419166 369 5382644
SGTC_2918 7977171 22.06 µM 1.54135796125901 0.060892353538866 no 262 0.0616148447253866 379 2236483
SGTC_672 1441-0018 53.7 µM 1.53703501961524 0.0613879272640203 no 263 0.0621423669520692 375 251141
SGTC_751 0833-0568 350 µM 1.53118841896291 0.0620631756737303 no 264 0.0628614160898193 381 6954252
SGTC_2262 9014885 67.46 µM 1.53094273020853 0.062091677675332 no 265 0.0628917736650505 284 6457424
SGTC_849 0386-0493 241 µM 1.52426736914425 0.062869991551568 no 266 0.0637209674810595 385 726119
SGTC_517 1365-0151 113 µM 1.52300383625327 0.0630181651150508 no 267 0.0638788728286965 399 768657
SGTC_2105 5350118 200 µM 1.52296356081412 0.063022892655469 no 268 0.0638839111030157 396 2133313
SGTC_1737 st035557 69.7 µM 1.5221586285253 0.0631174337363811 no 269 0.0639846692962054 345 5716916
SGTC_2495 cafestol 54.53 µM 1.52148102903381 0.063197104888963 no 270 0.0640695842395725 400 16667697 An anti-infammatory.
SGTC_679 0422-0091 41.4 µM 1.51812361173264 0.0635930208793579 no 271 0.0644916199078615 450 627384 YHR062C RPP1
SGTC_1338 1486-1223 76 µM 1.51616402207 0.0638249915358389 no 272 0.0647389414719948 433 3444526
SGTC_3111 9122088 49.47 µM 1.5157624482985 0.0638726098541743 no 273 0.064789715271641 277 16876704
SGTC_1945 st075991 56.6 µM 1.51475407869266 0.0639923033716302 no 274 0.0649173468440577 382 1084980
SGTC_146 3448-8650 53.125 µM 1.51432470805671 0.0640433225984637 no 275 0.0649717524494527 584 2891488 YIL048W NEO1
SGTC_2269 7935389 174.42 µM 1.51286497761688 0.064217009105179 no 276 0.0651569797967093 403 97605
SGTC_770 0389-1121 67.2 µM 1.51261546678068 0.0642467338391378 no 277 0.0651886815607124 464 6753108
SGTC_956 1185-0240 191 µM 1.50975665829977 0.0645880731725878 no 278 0.0655527640453309 396 1416193
SGTC_1770 st043884 66.3 µM 1.50956248400632 0.064611308411374 no 279 0.0655775501111717 411 670149
SGTC_3083 9117465 49.47 µM 1.50812917209574 0.0647830219383767 no 280 0.065760735148779 427 16420915
SGTC_1565 sinapyl alcohol 95.1 µM 1.49935618389941 0.065841775732967 no 281 0.0668906270531592 416 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2241 6772625 37.8075 µM 1.48747776289658 0.0672966146411076 no 282 0.0684443360354472 423 2285411
SGTC_2032 5185112 25.99 µM 1.48538704626554 0.0675552328796626 no 283 0.0687206625560779 398 5718189
SGTC_2362 9071156 126 µM 1.48533919574129 0.0675611608882251 no 284 0.0687269969348121 437 653133
SGTC_2730 imipramine 71.33 µM 1.4760909566064 0.0687144520014539 no 285 0.0699597381474018 525 3696 A tricyclic antidepressant.
SGTC_2638 epoxomicin 18 µM 1.47356803152351 0.069031691367168 no 286 0.0702989670182123 460 9915668 A protesome inhibitor.
SGTC_3045 9092950 49.47 µM 1.47339577695541 0.06905339221582 no 287 0.0703221741685844 466 44120432
SGTC_395 anisomycin 6.25 µM 1.47127418564413 0.0693211043123153 no 288 0.0706084907829825 372 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2325 6158266 200 µM 1.46896792623953 0.0696130248237596 no 289 0.0709207444679414 431 3623240
SGTC_297 0986-0032 24 µM 1.46261098489399 0.0704225706648605 no 290 0.0717869278613239 382 2847425
SGTC_1876 myriocin 605 nM 1.46092564222147 0.0706384054083636 no 291 0.0720179243451009 444 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2679 rapamycin 1 nM 1.46047155679197 0.0706966450709989 no 292 0.0720802595671686 579 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1944 st076371 56.9 µM 1.45568186833086 0.0713132057522974 no 293 0.0727402922426502 443 24208455
SGTC_1948 st076329 66.6 µM 1.45559176511101 0.071324843869562 no 294 0.0727527529227739 414 24208413
SGTC_1923 st058458 19.1 µM 1.45459904202616 0.0714531647666847 no 295 0.0728901481927335 504 3534982
SGTC_727 3032-0951 202 µM 1.45098940796596 0.0719212452348713 no 296 0.0733914048287514 414 3652836
SGTC_150 3970-0969 77.2 µM 1.44981181246521 0.0720744579021083 no 297 0.0735555022843484 544 6615640
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.44823582572282 0.072279895150753 no 298 0.0737755541836938 437 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2840 9008771 71.43 µM 1.44667884116097 0.072483295737827 no 299 0.0739934466065402 383 2992978
SGTC_2235 salicylic acid 500 µM 1.44413691729703 0.072816308235309 no 300 0.0743502326526222 403 338 A COX inhibitor and kinase inhibitor.
SGTC_934 2950-0684 338 µM 1.43130008608333 0.0745159562097309 no 301 0.0761721146394362 488 1121253
SGTC_2999 9069765 71.4286 µM 1.42812033034812 0.074941612164652 no 302 0.0766286133735045 483 2097066
SGTC_2429 5902844 64.44 µM 1.42714847499727 0.0750720783203468 no 303 0.0767685512369 488 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_631 k072-0230 41.5 µM 1.42496978274114 0.0753651849063749 no 304 0.0770829680214123 498 5773147
SGTC_2063 5246145 200 µM 1.42414328728604 0.0754766039700433 no 305 0.077202498961849 481 711240
SGTC_1313 1220-0047 237 µM 1.42401687971253 0.0754936559163273 no 306 0.0772207929194986 516 3528706
SGTC_26 0302-0163 425.158 µM 1.41435777342553 0.07680533776194 no 307 0.0786284408851851 452 3100915
SGTC_98 0074-0023 107.663 µM 1.41331434860556 0.0769480628433946 no 308 0.0787816584626736 506 3563821
SGTC_1130 3454-2858 15.9 µM 1.40867432723717 0.077585191630698 no 309 0.0794657447736853 494 715628 YIL048W NEO1
SGTC_1567 st069303 68.4 µM 1.4036380601883 0.0782812541423214 no 310 0.0802133277474399 509 5581319
SGTC_3251 9135047 49.47 µM 1.40184332806972 0.078530445311479 no 311 0.0804810183703105 401 17682963
SGTC_15 0266-0086 27.098 µM 1.40015492715663 0.0787654213159385 no 312 0.0807334648988375 590 1712902 YIL048W NEO1
SGTC_1424 4048-1941 275 µM 1.39893238947971 0.0789358950443093 no 313 0.0809166293411405 502 X1424
SGTC_232 clozapine 119 µM 1.39825201552367 0.0790308890734814 no 314 0.0810187008865664 473 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2921 7974240 10.71 µM 1.39670096841956 0.0792477704074786 no 315 0.0812517564331216 483 2979074 YDR527W RBA50
SGTC_745 0469-0705 296 µM 1.3961981536173 0.0793181751157424 no 316 0.0813274162882552 548 3486736
SGTC_1168 k815-0004 80.5 µM 1.39536086177485 0.0794355187395491 no 317 0.0814535236931847 488 642433
SGTC_1992 st073643 23.3 µM 1.39343602366975 0.0797057764388342 no 318 0.0817439893202633 463 3161292
SGTC_3153 9100258 49.47 µM 1.39169474741401 0.0799508597717558 no 319 0.0820074267845435 461 25236848
SGTC_2863 9028737 58.44 µM 1.39081860521915 0.0800743914223933 no 320 0.08214021989116 413 6460917
SGTC_2532 xanthone 78.9 µM 1.38739607454988 0.0805583341007148 no 321 0.0826605106660902 448 7020 An insecticide.
SGTC_528 3492-0019 172 µM 1.38641214055669 0.0806978695051803 no 322 0.0828105456986132 723 2869262
SGTC_2476 5806916 10.51 µM 1.38596894041351 0.0807607809855847 no 323 0.082878193903947 454 2870194
SGTC_93 0109-0045 59.227 µM 1.3827168079156 0.0812235488431294 no 324 0.0833758580715839 598 88733
SGTC_2345 9052315 157.45 µM 1.38088831845173 0.0814846140942411 no 325 0.0836566511176349 480 6469265
SGTC_3277 9138724 49.47 µM 1.37759644224449 0.0819562109121763 no 326 0.0841639600029347 369 15943418
SGTC_343 4130-2827 29.8 µM 1.37574738032758 0.0822220095151828 no 327 0.0844499287520995 523 1118244
SGTC_1874 staurosporine 7.6 µM 1.37397797785503 0.0824769646629634 no 328 0.0847242596603868 510 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2756 carbadox 75.1 µM 1.37058545783775 0.0829674604477746 no 329 0.0852521093824486 522 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1406 3909-7906 11.9 µM 1.36961412188082 0.083108300956066 no 330 0.0854036944824303 507 X1406
SGTC_623 k072-0108 16.9 µM 1.36792981084225 0.0833529465708312 no 331 0.085667023719723 510 5382803
SGTC_2033 5192550 145 µM 1.367513889672 0.0834134422438562 no 332 0.085732143327003 471 182073
SGTC_562 3772-2733 112 µM 1.36305664704971 0.0840638207204413 no 333 0.0864323292175448 585 2876874 YIL048W NEO1
SGTC_995 3931-2021 34.6 µM 1.36093678343749 0.084374473287015 no 334 0.0867668339851726 484 730143
SGTC_2580 diallyl disulphide 81.36 µM 1.3607073995297 0.0844081396251588 no 335 0.0868030876378386 477 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1990 st072050 59.8 µM 1.35857738937331 0.0847212395622217 no 336 0.0871402720284192 503 17233948
SGTC_1383 3049-0032 20.7 µM 1.35079482820268 0.0858726402433995 no 337 0.0883805826272117 528 712864
SGTC_691 1548-0686 185 µM 1.34732161471711 0.0863902525422299 no 338 0.0889383368237978 526 46495133
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.34197835845545 0.0871911070119439 no 339 0.0898015063998747 478 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1977 st070720 65.3 µM 1.3413187703174 0.0872903501186592 no 340 0.0899084890478773 470 682188
SGTC_2130 NSC 7 2.4545 µM 1.34129520397886 0.0872938975224413 no 341 0.0899123131687773 556 21448
SGTC_2086 5274770 176.623 µM 1.34092375148993 0.0873498258986135 no 342 0.0899726049093386 504 689278
SGTC_612 0302-0167 22.4 µM 1.33702152725112 0.0879389883357135 no 343 0.0906078050253281 589 235821
SGTC_1701 st028638 40.4 µM 1.33618967281194 0.0880649650179823 no 344 0.0907436428484413 523 3490878
SGTC_281 1672-3440 14.9 µM 1.32763632321228 0.0893681042247539 no 345 0.0921491394329795 566 6833000
SGTC_1428 4049-0204 61.7 µM 1.32460305989057 0.0898336637016756 no 346 0.0926514202512679 546 X1428
SGTC_2004 4023728 41.89 µM 1.32103143932789 0.0903841609460468 no 347 0.0932454407558825 551 360084 YDR527W RBA50
SGTC_1334 1486-0610 236 µM 1.31997121842021 0.0905480549808076 no 348 0.0934223137965293 541 3742339
SGTC_1522 st012842 45.6 µM 1.31861168248627 0.0907585412783189 no 349 0.0936494830281928 497 3491067 YOR116C RPO31
SGTC_2543 pimpinellin 60.67 µM 1.3183157031072 0.090804413537793 no 350 0.0936989931931658 496 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2779 methotrexate 400 µM 1.31679345654869 0.0910406101884142 no 351 0.0939539333973157 546 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_527 4476-4215 268 µM 1.3149999508561 0.0913194806623075 no 352 0.0942549594962513 548 4418754
SGTC_2678 equilin 100 µM 1.31166671843722 0.0918394431003187 no 353 0.0948163054489404 545 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1676 st018489 23.4 µM 1.30332602185882 0.0931501407962831 no 354 0.0962317404144758 553 3696235
SGTC_2232 chlorophetanol 41.5365 µM 1.30010529034628 0.0936599447979209 no 355 0.0967824423620601 698 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_513 4245-1575 41.7 µM 1.29763129877384 0.0940529454570458 no 356 0.0972070308198616 682 719745
SGTC_1669 st015249 58.4 µM 1.29479323230358 0.0945052774216196 no 357 0.0976957836272796 520 722793
SGTC_1159 4092-0538 61.2 µM 1.28122384751313 0.0966901500225496 no 358 0.100057526046104 608 717301
SGTC_1647 st011722 22.4 µM 1.28098421329664 0.0967290652940701 no 359 0.100099605574571 525 2854783
SGTC_2463 5473429 200 µM 1.27350167188143 0.0979499821547478 no 360 0.10142003983558 543 5399405
SGTC_441 propafenone 146 µM 1.27349794764022 0.0979505926335689 no 361 0.101420700191519 499 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3033 9090887 49.47 µM 1.27225164301195 0.0981550439227676 no 362 0.101641861986817 590 19325384
SGTC_574 1315-0397 40 µM 1.26826628653292 0.0988109237636581 no 363 0.102351436133363 649 6794277
SGTC_2015 5119600 184 µM 1.26493208186364 0.0993621011495325 no 364 0.102947837843264 577 2828786
SGTC_2187 6125751 200 µM 1.263100671016 0.0996658063755119 no 365 0.10327650144948 586 874498
SGTC_652 0437-0092 114 µM 1.26224265468302 0.0998083254253496 no 366 0.103430742209191 538 3091274
SGTC_3150 9097574 49.47 µM 1.25949717142146 0.100265358527447 no 367 0.103925405629949 540 17217476
SGTC_1362 1611-0397 101 µM 1.25839499811224 0.100449263370399 no 368 0.104124469976006 572 27816
SGTC_3068 9116768 49.47 µM 1.25836185854616 0.100454796733194 no 369 0.104130459615649 531 41904888
SGTC_1783 st039459 87.517 µM 1.25774428312513 0.100557954917602 no 370 0.104242125798659 638 729761
SGTC_926 2268-1401 59.4 µM 1.25299016517334 0.101354658612768 no 371 0.105104642949831 576 2931578
SGTC_3106 9121286 49.47 µM 1.25156789073111 0.101593897197388 no 372 0.105363680419521 520 15943471
SGTC_1264 0783-0040 158 µM 1.24911656350159 0.102007195833211 no 373 0.105811221641034 537 2855798
SGTC_581 0958-0271 211 µM 1.24908003550383 0.102013363764073 no 374 0.105817900967903 677 4591145
SGTC_1764 st044502 93.5 µM 1.24555610926466 0.102609672523993 no 375 0.10646370210777 579 8407
SGTC_1615 st002656 86.5 µM 1.24445514070735 0.10279649373647 no 376 0.106666049820852 581 1584458
SGTC_3075 9116269 49.47 µM 1.24244939253613 0.103137480341178 no 377 0.107035400747019 589 17015205 YNL244C SUI1
SGTC_3245 9134821 49.47 µM 1.24239432600531 0.103146853481601 no 378 0.107045554034412 587 17014901
SGTC_1867 st057372 64 µM 1.2413672080213 0.103321797593673 no 379 0.107235063629398 588 688837
SGTC_104 0074-0074 590.992 µM 1.24092324505271 0.103397482333359 no 380 0.107317052366829 448 3943124
SGTC_1782 st039423 80.636 µM 1.23215554594734 0.104900412584963 no 381 0.108945492747697 554 2068169
SGTC_2902 5787006 60.46 µM 1.23115357037971 0.105073169828791 no 382 0.109132716401314 577 591003
SGTC_2139 5578692 56.4705 µM 1.23038612282471 0.10520562973869 no 383 0.109276273723998 532 650991 YMR113W FOL3
SGTC_1096 rimcazole 32.2 µM 1.22781708266936 0.105649920087048 no 384 0.109757820734549 552 18528119 A dopamine reuptake inhibitor.
SGTC_2563 tomatine 8.54 µM 1.22747272052897 0.105709577105292 no 385 0.109822484390019 671 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_379 3970-0972 5.9 µM 1.22254636187899 0.106565683071752 no 386 0.110750541404216 591 2898042 YBL034C STU1
SGTC_18 0111-0177 500 nM 1.22209267017801 0.106644776893676 no 387 0.110836292328605 721 721752
SGTC_3072 9116419 49.47 µM 1.21885420989905 0.107210581022876 no 388 0.111449765936982 528 17170162
SGTC_2366 9070441 60.58 µM 1.21662723546697 0.107600918463956 no 389 0.111873037734087 618 6837235
SGTC_1891 st059073 26.2 µM 1.21401425602166 0.108060218111674 no 390 0.112371140166848 656 688754
SGTC_1126 isoteolin 1.0172 µM 1.2115158884496 0.108500690151375 no 391 0.112848874531448 603 133323
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.20949442770902 0.108858025855678 no 392 0.11323647529312 524 279621
SGTC_2303 7774051 200 µM 1.20915298763224 0.108918466001884 no 393 0.113302037652874 585 2953184
SGTC_732 3970-1727 52.7 µM 1.20690088856977 0.109317726567355 no 394 0.113735157727963 590 1275699
SGTC_2228 7354201 200 µM 1.20523620279226 0.109613523360517 no 395 0.114056065097553 595 753451
SGTC_366 0181-0206 4.31 µM 1.20484842611168 0.109682509562387 no 396 0.114130910717263 640 274874
SGTC_3306 9127676 59.7925 µM 1.20277232966191 0.110052381213752 no 397 0.114532217643706 582 41905287
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.20133954437713 0.110308163662244 no 398 0.114809758415405 572 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1746 st038117 42 µM 1.19979411592351 0.110584532901771 no 399 0.115109654977155 643 2898218
SGTC_817 1391-0715 46 µM 1.1977030098886 0.110959275365779 no 400 0.11551632857637 593 1353946
SGTC_2447 5741742 33.78 µM 1.19445143291966 0.111543788684912 no 401 0.116150713988663 638 1776504
SGTC_1275 0867-0008 21.1 µM 1.19341322575849 0.111730883180243 no 402 0.11635378889413 624 3422836
SGTC_876 0720-0963 56.8 µM 1.19177854809999 0.112025921949487 no 403 0.116674044662336 670 765861
SGTC_1227 3909-8010 46.6 µM 1.18779015857003 0.112748112454362 no 404 0.11745804632442 608 15982272
SGTC_1863 st057641 20.1 µM 1.18538488935829 0.113185245914345 no 405 0.117932651715791 687 3921635
SGTC_2474 5321570 43.32 µM 1.18529485226232 0.113201632696664 no 406 0.117950444053968 601 2841384
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.18350306454927 0.113528090743843 no 407 0.118304916351298 669 165521
SGTC_194 1486-1323 56.904 µM 1.18264306355347 0.113685018403074 no 408 0.11847531898816 624 5178754
SGTC_3181 9108277 49.47 µM 1.17931566078051 0.114293638623099 no 409 0.119136252238922 609 17097298
SGTC_3325 9138760 55.175 µM 1.17641960699256 0.114825245627773 no 410 0.119713620240289 634 43844959
SGTC_2710 st078562 53.7235 µM 1.17533627836213 0.115024555556879 no 411 0.119930102945993 630 17250908
SGTC_1662 st014054 52 µM 1.17425503078963 0.115223727808307 no 412 0.120146444815019 602 2838777
SGTC_1694 st024011 44.9 µM 1.17400844185146 0.115269185273751 no 413 0.120195822150994 685 2787533
SGTC_196 k015-0023 18.111 µM 1.17333345704509 0.115393680624958 no 414 0.120331055244311 672 5211998
SGTC_639 0833-0042 114 µM 1.17325482160818 0.115408190491647 no 415 0.120346816808771 683 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2402 5553605 200 µM 1.1728800596543 0.115477359648158 no 416 0.120421953491674 663 6758546
SGTC_1463 k081-0032 34.1 µM 1.17266270877826 0.115517489212064 no 417 0.120465545685589 521 977755
SGTC_480 am 92016 50 µM 1.17184647999933 0.115668278271214 no 418 0.120629348891308 590 2129 K+ channel blocker.
SGTC_1252 0493-0875 34.8 µM 1.16916076033276 0.116165421411237 no 419 0.121169433720803 627 3960963
SGTC_282 k297-0036 65.7 µM 1.16604795052924 0.116743516609693 no 420 0.121797529531194 603 5061378
SGTC_177 1327-0068 8.361 µM 1.16292879670087 0.117324832894389 no 421 0.122429196343963 660 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2213 7173844 200 µM 1.16206549275804 0.117486088347676 no 422 0.122604431442815 684 892728
SGTC_1467 k284-1082 293 µM 1.15976603104005 0.117916367354195 no 423 0.123072038900891 699 3334705
SGTC_1274 0865-0114 173 µM 1.15680331652264 0.118472397290807 no 424 0.123676363272424 655 870624
SGTC_644 1498-1197 63.3 µM 1.15366867436396 0.11906270871066 no 425 0.124318015723589 693 6741615
SGTC_1889 st059080 5.18 µM 1.15011075336922 0.119735244094398 no 426 0.125049128954025 719 176925 Isolated from Daphnopsis sellowiana.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.14929368727653 0.119890067373237 no 427 0.125217450121644 641 688662
SGTC_3157 9099274 49.47 µM 1.14754386225969 0.120222110842894 no 428 0.125578457984153 635 17217662
SGTC_1850 st056238 17 µM 1.14679065304088 0.120365237686636 no 429 0.125734076585727 720 5393177
SGTC_199 4063-0024 41.6 µM 1.14532347097161 0.120644380082497 no 430 0.126037593391016 681 306215
SGTC_212 3807-4682 38.772 µM 1.1433559194169 0.121019436499359 no 431 0.126445423231928 827 3125501 YBL034C STU1
SGTC_504 lovastatin 124 µM 1.14028287058651 0.121606863634873 no 432 0.127084235916525 589 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1899 st063254 59.6 µM 1.13830546055158 0.121985912465462 no 433 0.127496477325456 597 3093813
SGTC_2525 harmine 47.85 µM 1.13718560040255 0.122200945618603 no 434 0.1277303526391 616 5280953 A monoamine oxidase inhibitor
SGTC_2662 daunorubicin 22.37 µM 1.13652064466216 0.122328754851136 no 435 0.127869365220642 631 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1388 3346-4487 254 µM 1.13577433281948 0.122472313020847 no 436 0.128025510905381 715 3345614
SGTC_3218 9131285 49.47 µM 1.13359108828087 0.122892953619076 no 437 0.128483056466489 757 17156417
SGTC_632 0781-2353 4.65 µM 1.13212267237741 0.123176439043404 no 438 0.128791432096742 712 6811515 YHR007C ERG11
SGTC_826 1683-5028 118 µM 1.12978937575815 0.123627836361467 no 439 0.129282493005514 667 722377
SGTC_1630 st005209 31.3 µM 1.12837768196398 0.12390150305259 no 440 0.129580224548174 772 3367314
SGTC_3240 9133527 49.47 µM 1.12827826807974 0.123920791096101 no 441 0.129601209198669 669 17617455
SGTC_2236 dapsone 200 µM 1.12801420534842 0.123972034118343 no 442 0.129656959967194 720 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1286 0929-0070 131 µM 1.12696314270766 0.124176146363281 no 443 0.129879032287164 708 1420408
SGTC_214 4373-3496 70 µM 1.12607493766674 0.124348815484038 no 444 0.130066900650013 851 3779166
SGTC_2194 5927483 104.545 µM 1.12582858835466 0.124396736092091 no 445 0.130119040434632 719 760979
SGTC_1975 st070967 30.8 µM 1.12549887047872 0.124460894010232 no 446 0.130188847792624 762 261391
SGTC_1441 4106-0040 13 µM 1.12466630152288 0.12462300180754 no 447 0.130365233322509 677 2904180
SGTC_2774 tamoxifen 10.92 µM 1.12425653635836 0.124702840515304 no 448 0.13045210559898 683 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2888 9058547 12.99 µM 1.12111680365501 0.125315772903346 no 449 0.131119073448556 591 16476514
SGTC_1246 0422-0085 105 µM 1.11667838915534 0.126185814508796 no 450 0.132065930615516 715 264295
SGTC_2330 7979373 200 µM 1.11540352509933 0.126436496664717 no 451 0.132338769813588 685 1863007
SGTC_1950 st077106 7.18 µM 1.11432625723945 0.126648594906398 no 452 0.132569623235344 702 13831864
SGTC_88 0180-0332 8.668 µM 1.111530025834 0.127200287772044 no 453 0.133170136591734 701 3101745
SGTC_1106 tegaserod maleate 11.7 µM 1.11089014981433 0.1273267692227 no 454 0.133307817944801 725 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1375 2910-0797 186 µM 1.10716940468564 0.128063965582549 no 455 0.134110346395244 696 742508
SGTC_2129 girgensonine 121.053 µM 1.10712978124718 0.128071832151405 no 456 0.134118910607712 752 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.10193680015318 0.129105717261717 no 457 0.135244574224165 561 88881 An O-methylated flavonoid and antioxidant.
SGTC_808 0711-0032 135 µM 1.10039301685032 0.1294141861692 no 458 0.135580459876931 714 4252555
SGTC_567 1080-0542 68.4 µM 1.09828415030344 0.129836391155457 no 459 0.136040215339643 648 5950415
SGTC_2946 9065502 71.43 µM 1.09794838627022 0.129903700604027 no 460 0.136113513860515 537 16489101
SGTC_2555 cholic acid 100 µM 1.09694284839319 0.130105421777908 no 461 0.136333188142372 704 6708657 Influences liver metabolism.
SGTC_301 4119-0100 24.5 µM 1.09671742718895 0.130150673305836 no 462 0.13638246792768 754 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1033 k072-0102 21.3 µM 1.09531542834951 0.130432358021707 no 463 0.136689235300811 730 5965931
SGTC_2681 menadione 3.18 µM 1.09284867226928 0.130928993064798 no 464 0.137230123709488 705 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_48 0382-0018 55 µM 1.09217712585213 0.13106442232937 no 465 0.137377627281315 678 762596
SGTC_1070 indatraline 8.81 µM 1.09106605433909 0.131288702091713 no 466 0.13762190915643 706 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.09013158805839 0.131477537581228 no 467 0.137827591739758 738 6728940
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.08966766301591 0.13157135644613 no 468 0.137929782765627 731 3256 An antibiotic and ribosome inhibitor.
SGTC_1762 st045503 25.4615 µM 1.08494851657511 0.132528328183101 no 469 0.138972229041328 720 4645554
SGTC_308 4092-1169 104 µM 1.08335953891598 0.132851625457016 no 470 0.13932443376717 756 2268590 YDL196W YDL196W
SGTC_1768 st044301 37.178 µM 1.08310200508887 0.132904075016356 no 471 0.139381574549803 744 3931349
SGTC_149 3970-0822 46.1 µM 1.08137773690602 0.133255608220974 no 472 0.139764560351209 855 3114250 YBL034C STU1
SGTC_336 4111-0029 111 µM 1.07991148633913 0.133555041292929 no 473 0.140090798907039 661 3131175
SGTC_1982 st072467 71.9 µM 1.07843808154411 0.133856401154738 no 474 0.140419150040024 773 3163533
SGTC_3355 9151058 44.0485 µM 1.07842550086954 0.133858976328263 no 475 0.140421955915982 705 17015728
SGTC_1914 st062367 72.6 µM 1.07299198397853 0.134974362346661 no 476 0.1416373563685 690 978205
SGTC_3004 9076122 71.4286 µM 1.07145087481917 0.135291876574364 no 477 0.141983374007764 736 44782551
SGTC_2978 9011784 42.97 µM 1.07139631198877 0.13530312751381 no 478 0.141995635211351 837 2994934
SGTC_1040 k898-0338 155 µM 1.06770334043423 0.136066114936579 no 479 0.142827175579053 801 20969351
SGTC_337 1315-0038 354 µM 1.06564602782385 0.136492441559059 no 480 0.143291842059667 740 1626437
SGTC_2210 7115885 190.385 µM 1.06516026866273 0.136593236189057 no 481 0.143401704878041 767 2927039
SGTC_195 4234-0266 16.654 µM 1.06312158584587 0.137016816224046 no 482 0.143863408296465 787 2303354
SGTC_1419 3993-2473 62.6 µM 1.06143658640209 0.137367587766678 no 483 0.144245768676177 747 704026
SGTC_117 lucigenin 22.078 µM 1.06094670532371 0.137469682778318 no 484 0.144357060998925 772 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_444 curcumin 90.4 µM 1.05977336949407 0.137714425649401 no 485 0.144623857413924 762 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2329 6138490 200 µM 1.05873955734137 0.137930311934661 no 486 0.144859203635362 645 720019
SGTC_2349 9023730 187.07 µM 1.05238232612835 0.139262937177679 no 487 0.146312087054757 734 4126287
SGTC_2915 7971052 15.16 µM 1.05084792221426 0.139585892474722 no 488 0.146664220971135 586 5741558
SGTC_610 4215-0184 155 µM 1.0495788406298 0.139853388307584 no 489 0.146955894800862 794 5605015
SGTC_1663 st014140 55.4 µM 1.04835173212863 0.140112368221327 no 490 0.147238291623956 859 4207120
SGTC_1478 0453-0656 35.7 µM 1.04584650554131 0.140642104608109 no 491 0.147815952902218 765 5258496
SGTC_1064 honokiol 6.76 µM 1.04467999273123 0.140889229878961 no 492 0.148085447384189 763 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3031 9088762 49.47 µM 1.03728683193581 0.142462315854173 no 493 0.149801100409536 788 205253
SGTC_1263 0774-1208 64.8 µM 1.03717034794069 0.142487195527001 no 494 0.149828237291904 841 906585
SGTC_2089 5281248 129.67 µM 1.03599577918043 0.142738234436962 no 495 0.150102055823604 773 2737878
SGTC_2473 5854593 8.94 µM 1.03293133930546 0.143394599800395 no 496 0.150818015716164 741 2872951
SGTC_1425 4048-4433 7.33 µM 1.03218011034383 0.143555814344771 no 497 0.150993875375512 829 23734946
SGTC_2703 st077852 53.4 µM 1.03065968088633 0.143882474397563 no 498 0.151350219207226 731 6281836
SGTC_2757 clomiphene 4.22 µM 1.02800244828269 0.14445457655605 no 499 0.151974338016477 863 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1958 st076513 41.9 µM 1.02632602234156 0.144816298592225 no 500 0.152368967646818 759 732122 YGL099W LSG1
SGTC_543 3844-1095 191 µM 1.02482661709763 0.145140341217973 no 501 0.15272250243185 820 4230703
SGTC_502 l-744,832 89.3 µM 1.02430083923284 0.145254084697744 no 502 0.152846600839889 787 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1964 st076914 61 µM 1.02376919884274 0.145369157405891 no 503 0.152972150943341 794 24208661
SGTC_1368 1852-0141 284 µM 1.01937615827031 0.146322370643365 no 504 0.154012210246427 760 2838987
SGTC_2085 5307070 144.047 µM 1.01781372475434 0.146662401015453 no 505 0.154383244161642 731 2840351
SGTC_257 daunorubicin 18.5 µM 1.01724861621699 0.146785515318595 no 506 0.154517586921038 783 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_946 3434-1334 87.4 µM 1.01589289843947 0.147081154027949 no 507 0.154840195492473 757 4047976
SGTC_2960 9079389 5.97 µM 1.01588513168999 0.147082848857091 no 508 0.154842044960335 805 16457355
SGTC_406 estrone 100 µM 1.01423487320586 0.147443258686893 no 509 0.155235345982205 799 5870 A steroid.
SGTC_613 3914-0030 117 µM 1.01293202702813 0.147728212716686 no 510 0.155546314687581 568 1145395
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.01274545368069 0.147769049565067 no 511 0.155590880398751 704 6857784
SGTC_253 dyclonine 31.25 µM 1.01263560106211 0.147793097449666 no 512 0.155617124206109 853 3180 An oral anasthetic.
SGTC_1140 3229-1848 2.98 µM 1.01197303500284 0.147938195638904 no 513 0.155775473247002 808 2849525
SGTC_3175 9106517 49.47 µM 1.01067097754692 0.14822361654543 no 514 0.15608696607659 772 41468073
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.01055657839119 0.148248711306362 no 515 0.156114353531583 744 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1170 0310-0127 64.8 µM 1.01048082641481 0.148265329931404 no 516 0.156132490493988 811 774975
SGTC_2832 7992762 51.95 µM 1.0096348970278 0.148450996333893 no 517 0.15633512196483 676 2985177
SGTC_1004 4084-0029 199 µM 1.00890682446389 0.148610919717219 no 518 0.156509660989019 837 716894 YLR208W SEC13
SGTC_885 0865-0106 16.8 µM 1.00589876728618 0.149272869355233 no 519 0.157232134653853 782 2793380
SGTC_1002 4049-0206 172 µM 1.00144663050452 0.15025620957019 no 520 0.158305464890963 831 4662749
SGTC_2443 5493264 126.67 µM 0.998743453803684 0.150855359898327 no 521 0.158959492349719 809 5340055
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.998685630841792 0.150868193519612 no 522 0.158973501799127 1016 16725076
SGTC_2853 9015042 58.44 µM 0.996048265863989 0.151454320796173 no 523 0.159613347230472 726 6457456
SGTC_413 propylparaben 100 µM 0.99369754855796 0.151978018103699 no 524 0.160185068288052 786 7175 A pharmaceutical preservative.
SGTC_493 zm226600 134 µM 0.99312472438446 0.152105815021567 no 525 0.160324588215574 812 5240098 A potassium channel opener. YCR052W RSC6
SGTC_335 4077-0256 27.6 µM 0.992792387179631 0.152179992065155 no 526 0.160405570324323 893 3121989
SGTC_2397 5161689 200 µM 0.992584731616809 0.152226352589668 no 527 0.16045618425954 831 2259942
SGTC_3179 9107801 49.47 µM 0.992334591161852 0.152282210606513 no 528 0.160517167309554 804 4818259
SGTC_485 niflumic acid 177 µM 0.989317395108011 0.15295704224745 no 529 0.161253937927058 777 4488 A COX2 inhibitor.
SGTC_37 0566-0070 1.56 µM 0.988104046725489 0.153228980119199 no 530 0.161550847046151 866 1626686
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.987052475414721 0.1534649192046 no 531 0.161808457059653 837 442882
SGTC_2415 st077333 57.7 µM 0.986731685471403 0.153536942116716 no 532 0.161887096236168 912 2766255
SGTC_478 N-arachidonylglycine 10 µM 0.985209953629859 0.15387890224735 no 533 0.162260476199757 714 5283389
SGTC_2636 apigenin dimethyl ether 100 µM 0.982570393701953 0.154473252726404 no 534 0.162909460813555 801 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_126 0417-1624 672.48 µM 0.982468690027085 0.154496183694396 no 535 0.162934500263489 982 41912 YDL195W SEC31
SGTC_1355 1499-0035 1.68 µM 0.979462605571762 0.155174976966524 no 536 0.163675728298135 802 1548538
SGTC_1942 st076330 65.2 µM 0.978953352296677 0.15529016436345 no 537 0.163801514394904 798 24208414
SGTC_1256 0570-0116 285 µM 0.977719705000174 0.155569435468884 no 538 0.164106486594849 768 410638
SGTC_1521 st012942 49.4 µM 0.975784266067844 0.156008244245174 no 539 0.164585691679357 880 24207259
SGTC_3270 9137563 49.47 µM 0.97390860006656 0.156434278732109 no 540 0.165050961618529 781 17015724
SGTC_2533 agelasine 13.65 µM 0.973644987303587 0.156494216480964 no 541 0.165116420492301 858 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2082 5219693 150 µM 0.970170543432796 0.157285615211867 no 542 0.165980745439808 819 2834649
SGTC_3292 9120825 59.784 µM 0.967033336231769 0.158002455729548 no 543 0.166763684480336 864 24824900
SGTC_2640 pentamidine 10.38 µM 0.962128142498838 0.159127566697904 no 544 0.167992619534736 907 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1179 1021-1431 9.29 µM 0.959489375816714 0.159734989968423 no 545 0.168656134646793 878 2840958
SGTC_348 k064-0012 10.7 µM 0.959076097370331 0.159830260632984 no 546 0.168760205437969 795 5066323
SGTC_2167 5876490 200 µM 0.958383846589218 0.15998992441897 no 547 0.168934618808777 859 686534
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.957371766766602 0.160223542649456 no 548 0.169189821791669 876 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1232 0279-0259 161 µM 0.956323939234615 0.160465647336108 no 549 0.169454299465469 835 1560000
SGTC_1007 4101-0031 70 µM 0.955021752763677 0.160766855572499 no 550 0.169783348308149 868 1146276
SGTC_1209 2323-2347 50.3 µM 0.953062621273322 0.161220716579726 no 551 0.170279171671975 854 5412760
SGTC_2716 st080858 38.6235 µM 0.952348162665921 0.161386438996011 no 552 0.170460219772791 901 5296050
SGTC_60 0986-0278 202 µM 0.951253887787914 0.161640477092066 no 553 0.170737754502459 720 3110598
SGTC_2540 epiandrosterone 100 µM 0.94925142136255 0.162106028216413 no 554 0.171246377113424 1031 441302 A steroid.
SGTC_246 cycloheximide 667 µM 0.946599562733143 0.162723898334372 no 555 0.171921433424061 761 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2069 5228469 200 µM 0.943787394592937 0.163380791043549 no 556 0.172639151701338 813 2835210
SGTC_2044 5102272 200 µM 0.942793801725136 0.163613295071481 no 557 0.172893191367035 776 592666
SGTC_534 k292-0788 63.4 µM 0.940392891183274 0.164176002395259 no 558 0.17350803363579 961 4146317
SGTC_1807 st050092 58.9 µM 0.937885474766327 0.164765010047047 no 559 0.174151634282171 826 5008496
SGTC_3076 9116187 49.47 µM 0.936753827343045 0.165031288802692 no 560 0.174442600491972 834 27241210
SGTC_2469 5655019 90.81 µM 0.936568033040665 0.165075033162129 no 561 0.174490400928799 929 2788239
SGTC_598 3937-0236 20.2 µM 0.935826110071742 0.165249790126117 no 562 0.17468136291973 935 1379313
SGTC_1935 st074532 41.6 µM 0.934554963540179 0.165549481758994 no 563 0.175008848931246 948 2829742
SGTC_2699 st077704 54.6 µM 0.933944811672425 0.16569345889031 no 564 0.175166180884988 853 645852
SGTC_2869 9037858 32.47 µM 0.932079796026201 0.166134047191861 no 565 0.175647644272476 885 27187042
SGTC_2767 sibutramine 71.45 µM 0.928387529887451 0.167008532419129 no 566 0.176603292358786 906 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3030 9087619 49.47 µM 0.928093348337322 0.167078334537398 no 567 0.176679574847337 909 25236973
SGTC_2996 9066192 71.4286 µM 0.927962788331983 0.167109319273479 no 568 0.176713436268616 856 6472854
SGTC_2406 ethylparaben 405.7 µM 0.925898293881503 0.167599761239961 no 569 0.177249419022533 731 8434 A possible steroid mimic.
SGTC_3323 9138564 53.9225 µM 0.9258240508496 0.167617415691563 no 570 0.177268713056715 960 43912313 YNL103W MET4
SGTC_753 1322-0200 289 µM 0.925783349618709 0.16762709465578 no 571 0.177279290921142 900 5403907
SGTC_103 0844-0104 51.839 µM 0.924836713678035 0.167852311149046 no 572 0.177525425072747 971 5375804
SGTC_911 3456-4043 236 µM 0.923248051497082 0.16823071126573 no 573 0.177938976482249 903 914281
SGTC_667 1498-1044 59 µM 0.92268161917982 0.168365761202061 no 574 0.17808657369368 921 6739982
SGTC_1790 st045711 43.5 µM 0.922339171884827 0.16844744198634 no 575 0.178175843785501 872 585119
SGTC_1835 st008666 49.2 µM 0.918978539581257 0.169250374174053 no 576 0.179053398627687 781 690455
SGTC_3026 9090633 49.47 µM 0.918932480021297 0.169261395901 no 577 0.17906544492328 898 25236842
SGTC_661 1304-0007 33.6 µM 0.916432164568117 0.169860395039252 no 578 0.179720135804728 862 3117130
SGTC_736 0958-0254 92.6 µM 0.91504294590602 0.170193796021027 no 579 0.180084542512619 924 6812352
SGTC_720 r052-1644 49.9 µM 0.913555062511887 0.170551340425952 no 580 0.180475344093451 804 1422863 YOR257W CDC31
SGTC_1025 k007-0731 70 µM 0.911484377509609 0.171049734206591 no 581 0.181020106673981 884 6256118
SGTC_594 1487-1584 10.8 µM 0.910363823472458 0.171319828759896 no 582 0.181315334874231 908 5013332
SGTC_1290 0986-0249 10.2 µM 0.90839248860026 0.171795653998562 no 583 0.181835446428394 879 53329
SGTC_2347 9049783 174.81 µM 0.907930605525769 0.171907261616049 no 584 0.18195744319498 935 6467988 YPL169C MEX67
SGTC_874 0599-0792 117 µM 0.906789088828294 0.17218329178958 no 585 0.182259170487522 971 765305
SGTC_2746 daunorubicin 9.88 µM 0.906477413170184 0.17225870721539 no 586 0.182341607344466 783 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2064 5220758 200 µM 0.90647217112679 0.172259975800492 no 587 0.182342994041348 919 788518
SGTC_838 0109-0203 71.4 µM 0.904345420024273 0.172775145631042 no 588 0.182906134837887 911 759422
SGTC_3119 9125183 49.47 µM 0.90338014246125 0.17300929162008 no 589 0.183162087672084 754 22695334
SGTC_1279 0874-0590 65.2 µM 0.902833095226416 0.173142077785226 no 590 0.183307241757062 912 3523074
SGTC_1997 st073024 93.8 µM 0.902373352288635 0.173253722540816 no 591 0.18342928588427 914 686268
SGTC_1625 st003711 30.1 µM 0.900774892930316 0.173642251789945 no 592 0.183854009669648 913 24207034 YER133W GLC7
SGTC_1759 st043059 70 µM 0.899855767217507 0.173865909753188 no 593 0.184098506053636 908 669426
SGTC_1074 carmofur 3.8 µM 0.897918265336766 0.174337976905434 no 594 0.184614563058891 975 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1309 pyrazolanthrone 13.4 µM 0.897589712707188 0.174418108554543 no 595 0.184702162742872 969 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3027 9089541 49.47 µM 0.896435487479219 0.174699801312526 no 596 0.185010110532116 891 9943819
SGTC_1846 st056244 14.8 µM 0.893474267398441 0.175423817749255 no 597 0.185801623236002 926 5393182
SGTC_2257 7960413 200 µM 0.892341926952595 0.175701176297794 no 598 0.186104843953746 962 2974689 YIL048W NEO1
SGTC_1547 harmine 94.2 µM 0.891391133802702 0.175934280622003 no 599 0.18635968628267 993 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2318 6029776 164 µM 0.891118062692289 0.176001265181164 no 600 0.186432917831691 916 818325
SGTC_2761 levamisole 97.89 µM 0.890868592683347 0.176062474484358 no 601 0.186499835672785 902 26879 An alkaline phosphatase inhibitor.
SGTC_2894 9048625 32.47 µM 0.889325532789752 0.176441375011441 no 602 0.186914076587252 934 4092861
SGTC_2174 5790901 200 µM 0.889165259765275 0.176480759827951 no 603 0.1869571351685 881 786020
SGTC_2107 5363541 170.161 µM 0.887880762740519 0.176796607553044 no 604 0.187302446832049 954 244052
SGTC_1485 3909-9022 254 µM 0.887144007980503 0.176977930910922 no 605 0.187500686635683 989 714516
SGTC_1183 1254-0324 198 µM 0.884962112524173 0.177515608109643 no 606 0.188088533021269 947 5799357
SGTC_13 0199-0087 65 µM 0.883301093056165 0.177925618046813 no 607 0.188536806695719 986 4589825
SGTC_2309 7664088 163.95 µM 0.88265416106407 0.17808546972668 no 608 0.188711577931439 982 704922
SGTC_129 0088-0017 176.636 µM 0.882088730802105 0.178225257109962 no 609 0.188864412906739 897 182446
SGTC_190 3970-0790 3.722 µM 0.881607064997735 0.178344390520884 no 610 0.188994666612161 906 2832352
SGTC_1614 st002383 48.6 µM 0.880536800430005 0.178609285305596 no 611 0.189284289224071 933 1947235
SGTC_3017 9080681 49.47 µM 0.880116835067588 0.178713296074263 no 612 0.189398009993137 913 16451914
SGTC_786 4544-0069 423 µM 0.879144473126113 0.178954262532777 no 613 0.189661473408441 945 748821 YLR208W SEC13
SGTC_2311 7694451 200 µM 0.876307294810519 0.179658527526347 no 614 0.190431500203102 901 2163142
SGTC_584 0986-0246 15.4 µM 0.873672152253165 0.180314199447869 no 615 0.191148410304975 1056 53315 YDR232W HEM1
SGTC_416 estradiol valerate 100 µM 0.873365653354466 0.180390559371745 no 616 0.191231902903818 930 13791 A steroid.
SGTC_2819 7996655 46.38 µM 0.872384798892925 0.180635061900103 no 617 0.191499245232849 841 6456960
SGTC_2052 5265182 7.135 µM 0.871164480593614 0.180939546745687 no 618 0.191832175461822 951 1239884
SGTC_3272 9137413 49.47 µM 0.871107063848371 0.18095388086797 no 619 0.191847848762794 954 17614870
SGTC_2372 9071633 200 µM 0.871052470962358 0.180967510672184 no 620 0.19186275194957 1012 21321366
SGTC_2601 securinine 100 µM 0.868770605685134 0.181537782507517 no 621 0.192486306881202 893 442872 A GABA receptor antagonist.
SGTC_2212 7123476 200 µM 0.86828700984076 0.18165878454227 no 622 0.192618615847995 901 1085715
SGTC_2233 sulbentine 40.3845 µM 0.867843428630265 0.181769818754824 no 623 0.192740025909005 976 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2378 9074213 121.43 µM 0.867294820678406 0.181907201253825 no 624 0.192890246894095 989 657714
SGTC_417 st075190 100 µM 0.865696755801562 0.182307758901308 no 625 0.193328239789207 983 222757
SGTC_323 4013-0906 34.3 µM 0.865246945479559 0.182420603940061 no 626 0.193451631839829 973 2910086
SGTC_2203 7227154 166.4 µM 0.863548678233661 0.182847045747433 no 627 0.1939179337923 988 896304
SGTC_2879 9041815 71.43 µM 0.862777210324016 0.183040969834398 no 628 0.194129985765762 881 4942971
SGTC_2215 7188065 200 µM 0.86197526460533 0.183242691106377 no 629 0.194350564785224 949 940217
SGTC_1157 4092-0394 27.6 µM 0.857191984323183 0.184448754195785 no 630 0.19566939583616 1037 3659885
SGTC_2628 lathosterol 100 µM 0.855901740831838 0.184774921730369 no 631 0.196026065990389 989 6710616
SGTC_1350 1495-0454 146 µM 0.853906926208765 0.185279906719139 no 632 0.196578280799034 1001 1069057
SGTC_655 k060-0012 42 µM 0.850692829638753 0.186095352247158 no 633 0.197470003669168 939 5994525
SGTC_2680 butyl paraben 22.24 µM 0.850057674576013 0.186256759720725 no 634 0.197646510855237 978 7184 An antifungal and steroid mimetic.
SGTC_205 1486-1330 71.903 µM 0.849198390146347 0.186475261625866 no 635 0.197885454456455 948 4118834
SGTC_376 3970-0862 59.1 µM 0.845970239108291 0.187297545031117 no 636 0.198784673428388 1001 3135186
SGTC_1805 st050013 60.3 µM 0.845757204936081 0.187351888412852 no 637 0.198844101775337 946 4037144
SGTC_1416 3966-0321 25.3 µM 0.845745908279959 0.187354770375214 no 638 0.198847253407238 999 582530 YLR208W SEC13
SGTC_66 0109-0187 42.4 µM 0.841918646675205 0.188332744647391 no 639 0.199916746078001 894 759417
SGTC_575 k072-0246 11.9 µM 0.841709520996642 0.188386272793806 no 640 0.199975283801612 1001 6796779
SGTC_1836 st055642 81 µM 0.84158620491401 0.188417841375348 no 641 0.20000980683517 1019 8571
SGTC_1381 2324-0066 62.1 µM 0.8411198353943 0.1885372602038 no 642 0.200140402012945 917 10885928
SGTC_230 MPP+ 141.667 µM 0.838622925888185 0.189177413693045 no 643 0.200840470711368 940 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2734 clemastine 41.6 µM 0.836486421677054 0.189726228289644 no 644 0.201440656179112 911 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2914 7968218 45.32 µM 0.83430956730102 0.190286413849782 no 645 0.202053280974665 927 2977111
SGTC_2008 4012253 172 µM 0.833843107263354 0.190406583413034 no 646 0.202184700166015 990 603940
SGTC_1932 st074806 40.9 µM 0.83337971491881 0.190526008812202 no 647 0.202315305696591 1111 17251235
SGTC_2320 7373003 200 µM 0.833087446869763 0.19060135573095 no 648 0.20239770637936 1021 5415828
SGTC_1896 st058441 89 µM 0.832828606597847 0.19066810021493 no 649 0.202470699346029 901 688759
SGTC_3344 9148862 3.898 µM 0.832647898653882 0.190714706020103 no 650 0.202521668321651 1021 4905352
SGTC_563 tetrahydrosecaminediol 614 µM 0.829884304330916 0.191428326527331 no 651 0.203302099925655 1043 334274 A psychoactive constituent of the cannabis plant.
SGTC_2121 5257820 149.641 µM 0.829843690275784 0.191438826149787 no 652 0.203313582590944 1058 791256
SGTC_187 1488-2104 32.728 µM 0.827504730203283 0.192044093744638 no 653 0.203975521068975 1049 2852859
SGTC_529 4076-0302 30.3 µM 0.826128913845992 0.192400668888108 no 654 0.204365483717517 945 5816522
SGTC_1870 st057514 26.5 µM 0.823252322793505 0.193147512026111 no 655 0.205182260023636 993 5393161
SGTC_490 phenamil 164 µM 0.822709561470146 0.193288626184542 no 656 0.205336588349449 937 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1486 3970-0793 4.53 µM 0.822363893502937 0.193378530231637 no 657 0.205434911234973 1039 2844330
SGTC_2856 9022925 19.48 µM 0.821570378030244 0.19358501047793 no 658 0.2056607270098 989 4944862
SGTC_650 1328-0195 38 µM 0.821400469680114 0.193629239712264 no 659 0.205709098059613 1020 2780821
SGTC_411 enrofloxacin 100 µM 0.820304618026475 0.193914651400995 no 660 0.206021237217401 1060 71188 A bacterial gyrase inhibitor.
SGTC_1084 voriconazole 435 nM 0.818795640732478 0.194308079915367 no 661 0.206451509248861 1052 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3191 9110352 49.47 µM 0.81873183283447 0.19432472695064 no 662 0.20646971525258 999 17122424
SGTC_2146 5545642 200 µM 0.818063195804616 0.194499221908802 no 663 0.206660551472247 1052 825326
SGTC_274 sirtinol 40.1 µM 0.817809360986046 0.194565490433966 no 664 0.206733026011903 1017 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1248 0469-0687 58.6 µM 0.816578647183216 0.194886987022163 no 665 0.207084630887718 1003 4017482
SGTC_184 1494-0393 24.714 µM 0.816198903098012 0.194986251895286 no 666 0.207193192049211 1010 3090647
SGTC_853 0419-0306 21 µM 0.814036404244798 0.195552113528516 no 667 0.207812048112893 944 762713
SGTC_3214 9129694 49.47 µM 0.813767686005486 0.195622498688477 no 668 0.207889025106232 985 17158655
SGTC_1204 4049-0315 18.3 µM 0.813707046300538 0.195638384126213 no 669 0.207906398276748 970 588402
SGTC_211 3455-0679 143.504 µM 0.813633028838513 0.195657775120045 no 670 0.20792760531332 1045 748649
SGTC_2790 5423970 71.43 µM 0.8126985294532 0.195902694344597 no 671 0.208195462279943 1039 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_520 3584-0023 682 µM 0.811423188211146 0.196237243468584 no 672 0.208561343625035 935 1340790
SGTC_1336 1486-0901 104 µM 0.807401746834714 0.197294419142971 no 673 0.209717530429612 1018 5006114
SGTC_1571 st070080 73.4 µM 0.806753822887685 0.197465070145234 no 674 0.209904164061815 1022 4315245
SGTC_711 k292-0785 179 µM 0.805334356987744 0.197839242630468 no 675 0.210313380356028 1078 4146315
SGTC_1299 1079-1439 3.74 µM 0.803897100695039 0.198218540793403 no 676 0.210728202319162 1028 323161
SGTC_2685 mycophenolic acid 18.85 µM 0.802843399198479 0.198496895863355 no 677 0.211032627105652 1025 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_506 n9-isopropylolomoucine 153 µM 0.802467047858268 0.198596373275166 no 678 0.211141421181533 1037 6610355
SGTC_450 aminopyrene 156 nM 0.801935040988592 0.198737044933008 no 679 0.211295267566896 1023 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1776 st049249 45.9 µM 0.801738080841776 0.198789139777954 no 680 0.211352241391156 1080 1822314
SGTC_1714 st033236 13.627 µM 0.800246760348764 0.199183852707599 no 681 0.21178392125087 1050 2916566
SGTC_2820 7989630 71.43 µM 0.800148828507968 0.199209789172587 no 682 0.211812286788544 942 2984098
SGTC_666 0272-0154 136 µM 0.797681787552983 0.199863836106924 no 683 0.212527587663188 1043 6870312
SGTC_1674 st016616 23.6 µM 0.790562100956227 0.201758592690029 no 684 0.214599785006197 1068 625830
SGTC_2581 avocatin a 64 µM 0.790281953310694 0.201833367465909 no 685 0.214681561901053 1035 6710728 A skin care supplement.
SGTC_656 4090-1979 187 µM 0.790254968276498 0.201840570972114 no 686 0.214689439961757 1098 22330961
SGTC_2331 7980721 200 µM 0.789833477004034 0.201953105723652 no 687 0.214812512706162 1058 2981221
SGTC_1907 st060210 83.7 µM 0.789804682196573 0.201960795074021 no 688 0.214820922100478 1105 688793
SGTC_2401 5128683 200 µM 0.788894918406458 0.202203828148631 no 689 0.215086712996563 1027 708373
SGTC_394 menadione 8.33 µM 0.785592985397177 0.203087370867313 no 690 0.216052987646498 1047 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2652 actinonin 100 µM 0.784789785129758 0.203302642027169 no 691 0.216288415092865 1049 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.784739221309036 0.203316198534757 no 692 0.216303240910844 1050 4330530
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.784233486346416 0.203451819228773 no 693 0.216451559825736 1089 688751
SGTC_2053 5265679 138 µM 0.783439939982061 0.203664729768066 no 694 0.216684404926448 1078 764595
SGTC_1987 st072290 61.9 µM 0.783206821066026 0.203727301413185 no 695 0.216752834999965 1063 54697379
SGTC_671 0560-0003 407 µM 0.781343167855778 0.204227938063388 no 696 0.217300343649111 1025 3238678
SGTC_627 1391-0720 175 µM 0.778919698210757 0.204880053864289 no 697 0.21801350976476 1031 997839
SGTC_2754 granisetron 64.02 µM 0.778424154749796 0.205013548762858 no 698 0.218159501722975 1045 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2423 st077119 87.2 µM 0.777243392381345 0.205331843705007 no 699 0.21850759286157 1073 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3200 9114385 49.47 µM 0.776305601773561 0.205584850423118 no 700 0.218784283162647 1052 17018030 YLR208W SEC13
SGTC_1392 3455-1037 33.9 µM 0.774626410316456 0.206038341931715 no 701 0.219280223354101 1062 981132
SGTC_2515 chrysin 20.77 µM 0.772215126509841 0.206690582794826 no 702 0.219993511957191 1082 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1120 ficusin 1.78878 µM 0.772087977504921 0.206725009900122 no 703 0.220031161172891 1085 6199 A DNA cross-linker.
SGTC_1326 1431-2094 10.8 µM 0.770349821083287 0.207195976780493 no 704 0.220546205218874 1076 616278
SGTC_2031 5180455 200 µM 0.769586069703401 0.207403121630592 no 705 0.220772735461071 1093 29949
SGTC_955 1216-0110 33 µM 0.766532401796496 0.208232560682332 no 706 0.221679789975251 1040 3619719
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.766062491849234 0.208360371431578 no 707 0.221819559756479 1151 91467 include heat shock
SGTC_2361 9034121 116 µM 0.76548458234782 0.208517620397608 no 708 0.221991521871397 1065 6496917
SGTC_754 3474-0146 171 µM 0.763106399192521 0.209165459247919 no 709 0.222699971999058 1062 24762078
SGTC_1024 4507-0395 26 µM 0.762718433326389 0.209271257013389 no 710 0.222815667430664 1073 4201836
SGTC_2907 7721985 69.9 µM 0.76262929330447 0.209295569825693 no 711 0.22284225474425 1087 3267881
SGTC_1641 st009299 47.1 µM 0.761798711428744 0.209522189735763 no 712 0.223090074792852 1057 4046054
SGTC_2877 9040724 71.43 µM 0.760685234012922 0.20982622256678 no 713 0.223422548233413 1095 6463895
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.760179353031713 0.209964438013753 no 714 0.223573692418962 1140 5106787 A p450 inhibitor.
SGTC_1013 4112-3890 241 µM 0.760144986084945 0.209973829599321 no 715 0.223583962485035 1028 705171
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.759646039250005 0.210110206494321 no 716 0.223733095766739 1099 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1953 st076800 12.1 µM 0.758963536909137 0.210296838771025 no 717 0.223937184636461 1016 297591
SGTC_210 3551-0445 56.827 µM 0.757914221418648 0.210583966985767 no 718 0.22425116799849 1112 2865180 YOR207C RET1
SGTC_2536 dehydroabietamide 32.04 µM 0.757183710165429 0.210783995328912 no 719 0.224469904075537 1117 3983547
SGTC_1779 st039427 55 µM 0.755963043907836 0.21111848632253 no 720 0.22483567670313 1161 1124498
SGTC_260 nsc-65238 3.989 µM 0.755460262772153 0.211256350471897 no 721 0.224986433265821 1084 3246252
SGTC_2720 fluspirilene 36.88 µM 0.755448753599289 0.211259506940241 no 722 0.224989884907848 1053 3396 An atypical antipsychotic.
SGTC_761 k216-0224 480 µM 0.754063591196283 0.211639598816185 no 723 0.22540551915616 1144 1340404
SGTC_755 1995-0008 37.3 µM 0.753792648638663 0.211713992881252 no 724 0.22548686945396 1134 689533
SGTC_1141 3253-0389 52.6 µM 0.751766874540308 0.212270704693736 no 725 0.226095632974972 1110 5402031
SGTC_2626 ethyl orsellinate 100 µM 0.751027219084036 0.212474185676868 no 726 0.226318137441131 1117 75653 A natural product.
SGTC_2122 5258151 111.688 µM 0.748902125090112 0.213059437738004 no 727 0.226958099692635 1095 2173356
SGTC_1273 0849-0096 14.1 µM 0.748219807500673 0.213247547647695 no 728 0.227163792724581 1102 5286025
SGTC_3334 9142812 21.919 µM 0.746421643186401 0.2137437519221 no 729 0.227706374532554 1085 45283678
SGTC_3128 9127691 49.47 µM 0.74478519094749 0.214195915620207 no 730 0.228200794403851 1018 41316314
SGTC_3052 9092717 49.47 µM 0.742388458747627 0.214859153641256 no 731 0.228926005066555 1125 25237534
SGTC_2711 st079103 59.1 µM 0.741886850239035 0.214998112549552 no 732 0.229077946822836 1124 54693780
SGTC_2585 alliin 100 µM 0.74162736061677 0.215070018559225 no 733 0.229156570773933 1164 87310 A garlic compound which reacts with lipids.
SGTC_2467 5474540 200 µM 0.740907909714517 0.21526945539254 no 734 0.229374639634899 1131 5413519
SGTC_519 k048-0011 62.8 µM 0.739038661592945 0.215788125467555 no 735 0.229941760657195 1101 6836379
SGTC_522 1273-0010 11.6 µM 0.739029843741895 0.215790573918174 no 736 0.229944437810013 1166 5705015
SGTC_3090 9117696 49.47 µM 0.73897589605995 0.215805553908891 no 737 0.229960817031843 1111 7923821
SGTC_1900 st060200 72.8 µM 0.735127681291416 0.216875665737354 no 738 0.231130868642656 1150 688945
SGTC_1152 3909-8331 15.9 µM 0.727838332755551 0.218911074902503 no 739 0.233356278091471 1134 16001939
SGTC_3285 9112818 20.8695 µM 0.727483749008915 0.219010365015816 no 740 0.233464833500611 1203 17017947 YPR165W RHO1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.727306905702824 0.21905989414359 no 741 0.233518984344045 1237 688801
SGTC_1023 4482-3888 16 µM 0.72730635658451 0.219060047947122 no 742 0.23351915249934 1136 3303168
SGTC_2022 5136654 200 µM 0.724745530570415 0.219777989426561 no 743 0.234304078659128 1130 1713771
SGTC_879 0831-1030 162 µM 0.723250259177489 0.220197820728821 no 744 0.234763073031637 1155 1549252
SGTC_1052 3253-3998 198 µM 0.72199913831927 0.2205494543674 no 745 0.23514750364878 1157 5450317
SGTC_3317 9138495 8.753 µM 0.721776428286735 0.220612081828234 no 746 0.235215971965098 1167 17020139
SGTC_496 calpeptin 138 µM 0.721060099914407 0.220813586938961 no 747 0.235436269261866 1128 73364 A calpain inhibitor.
SGTC_1631 benzylvanillin 81.9 µM 0.720839993472295 0.220875524637458 no 748 0.235503982942583 1143 75506
SGTC_1642 st009582 77.7 µM 0.720760827861369 0.22089780418078 no 749 0.235528340126897 1156 6739311
SGTC_1516 st013856 110 µM 0.719965683708641 0.221121652598624 no 750 0.23577306222331 1108 5281404 A mutagen and neurotoxin.
SGTC_2831 7999036 19.48 µM 0.71868984693517 0.221481096326717 no 751 0.236166020229754 1156 2988270
SGTC_2589 lobaric acid 100 µM 0.718422226975095 0.221556535725398 no 752 0.236248492984305 1165 73157 A novel microtubule depolymerizer.
SGTC_142 0335-0849 62.6745 µM 0.715947214676202 0.222254912648124 no 753 0.23701197153066 1186 3889043 YPR107C YTH1
SGTC_326 k292-0812 17.5 µM 0.715738686968642 0.222313810456484 no 754 0.237076358921735 1143 3579357
SGTC_2298 7976326 193.81 µM 0.715210851305043 0.222462935296073 no 755 0.23723938242473 1071 2235818
SGTC_41 0478-0632 82.643 µM 0.714452985999363 0.222677148141815 no 756 0.237473558851538 1186 3750424
SGTC_1830 st055982 50.3 µM 0.714129843150107 0.222768521154517 no 757 0.237573446879217 1120 455313 An antimicrobial agent.
SGTC_1847 st056231 15 µM 0.71244506052962 0.223245262196065 no 758 0.238094610341679 1203 5393180
SGTC_169 k015-0017 16.025 µM 0.711152786249025 0.223611328807364 no 759 0.238494781172141 1197 1840002
SGTC_1304 1165-0502 251 µM 0.710673641490089 0.223747144352919 no 760 0.238643248575139 1167 767425
SGTC_577 r071-0003 38.6 µM 0.710522856247835 0.223789894746807 no 761 0.238689981227689 1221 4568517 YMR134W ERG29
SGTC_2307 7538926 6.34 µM 0.708858103583043 0.224262191295375 no 762 0.239206268305202 1184 96582
SGTC_659 k018-0002 107 µM 0.708655133311891 0.224319813399757 no 763 0.239269256858402 1172 6797879 YHR007C ERG11
SGTC_2980 9014342 25.29 µM 0.708457431485289 0.224375947902268 no 764 0.239330619145678 1180 2996599
SGTC_1237 0330-0133 46.1 µM 0.7051184161313 0.225325215501124 no 765 0.240368273366887 1130 X1237 YHR072W ERG7
SGTC_2308 7584454 197.62 µM 0.705112440687774 0.225326916329871 no 766 0.240370132528999 1219 893577
SGTC_3059 1327-0034 3 µM 0.704683978266015 0.22544889128028 no 767 0.240503462062207 1152 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3113 9123498 49.47 µM 0.70406489303594 0.225625198854732 no 768 0.240696180979277 1235 8897275
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.703722911702579 0.225722624216893 no 769 0.240802674517164 1153 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.701412714009908 0.226381388011363 no 770 0.241522744905962 1219 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1163 k060-0048 49.9 µM 0.699990949465862 0.226787350052497 no 771 0.241966478296909 1204 6809982
SGTC_3180 9109287 49.47 µM 0.699816890057636 0.226837078127031 no 772 0.242020832687026 1181 18891271
SGTC_3216 9129716 49.47 µM 0.697739747048601 0.227430984039409 no 773 0.242669983119306 1157 8056934
SGTC_3356 9151811 4.48 µM 0.696875293895499 0.227678410187003 no 774 0.242940420256332 1181 1859254 YPR165W RHO1
SGTC_1638 st008370 60.6 µM 0.696756231485405 0.227712500424557 no 775 0.24297768073356 1207 24207134
SGTC_944 3370-0224 231 µM 0.696498124171203 0.227786412200382 no 776 0.243058465805713 1210 4580514
SGTC_14 0354-0009 295 µM 0.696210929040908 0.227868669449215 no 777 0.243148372152105 1234 1713507
SGTC_477 mead ethanolamide 10 µM 0.694576726117026 0.228337049140075 no 778 0.243660300964839 1077 16061185
SGTC_1213 1315-0166 115 µM 0.694309119323732 0.228413799575097 no 779 0.243744186625814 1158 768401
SGTC_2611 pyromycin 23.93 µM 0.693878024834851 0.228537469253345 no 780 0.243879352918382 1192 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_764 1951-2361 146 µM 0.693683355832728 0.228593326998141 no 781 0.243940403109687 1172 5438930
SGTC_1645 Cervolide 78 µM 0.692779497933022 0.22885277772438 no 782 0.244223970187423 1152 23173 A fragrance.
SGTC_2012 4023501 200 µM 0.692476248290838 0.228939861983664 no 783 0.244319148408686 1175 3477460
SGTC_1913 st060213 96.1 µM 0.691569594162282 0.229200336904922 no 784 0.244603830938504 1213 688959
SGTC_738 1315-0003 72.4 µM 0.689150584076148 0.229896112907891 no 785 0.24536425518226 1212 6251474
SGTC_2830 7992007 71.43 µM 0.688044489794194 0.230214650532995 no 786 0.245712382608599 1144 1952075
SGTC_1682 st012968 530 nM 0.686243015025699 0.230733974779929 no 787 0.246279938397775 1178 24207270
SGTC_250 brefeldin a 552.239 µM 0.685771441298784 0.230870026764879 no 788 0.246428623990404 1116 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_445 e6 berbamine 66 µM 0.684506889261985 0.231235079009562 no 789 0.246827570286221 1256 6610268 A calcium/calmodulin antagonist.
SGTC_2340 7987427 183.45 µM 0.683976391107127 0.23138831961899 no 790 0.246995037003617 1181 2239331
SGTC_2373 9071805 200 µM 0.682582512688529 0.231791227499961 no 791 0.247435343641652 1229 10149009
SGTC_58 0957-0393 9 µM 0.680189601991469 0.232483821436149 no 792 0.248192207677575 1186 6997992
SGTC_1500 4488-1866 171 µM 0.680131367794054 0.232500690827591 no 793 0.24821064219936 1276 2900003
SGTC_2246 7293507 91.5585 µM 0.678972041186849 0.232836668357099 no 794 0.248577788637188 1250 887656
SGTC_835 0312-0010 67.2 µM 0.677644913408073 0.23322160625632 no 795 0.248998430821228 1198 1626196
SGTC_1594 piperine 70.1 µM 0.676731009234671 0.233486892495107 no 796 0.249288319042076 1218 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2186 6124449 200 µM 0.67648285435419 0.233558955271072 no 797 0.249367064142949 1184 3834182 YLR033W RSC58
SGTC_559 1550-0661 158 µM 0.676105847954285 0.233668459400221 no 798 0.249486722014707 1240 5830875
SGTC_1001 4048-4355 44.4 µM 0.675780135083515 0.233763087881034 no 799 0.249590124420562 1224 21824233
SGTC_913 3487-1245 167 µM 0.675696218943077 0.233787471251397 no 800 0.249616768538121 1189 4016153
SGTC_3069 9117009 49.47 µM 0.674999747027369 0.233989898303325 no 801 0.249837962832888 1110 41904981
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.674490759476595 0.23413789508421 no 802 0.249999679274407 1201 140250 A respiratory chain inhibitor.
SGTC_1606 st000094 49.2 µM 0.673643281850078 0.234384428567563 no 803 0.250269064579532 1267 1242210
SGTC_221 trifluoperazine 10.304 µM 0.673024853983963 0.234564421490523 no 804 0.250465739581942 1251 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_183 3914-0051 30.55 µM 0.672871101098129 0.234609183005725 no 805 0.250514649424336 1222 1596232
SGTC_3093 9117344 49.47 µM 0.672217099631858 0.234799632833709 no 806 0.250722748286786 1227 24824913
SGTC_440 fluspirilene 35.1 µM 0.672032800953309 0.234853317336337 no 807 0.250781407414085 1299 3396 An atypical antipsychotic.
SGTC_3073 9114972 49.47 µM 0.671270435942008 0.235075459279875 no 808 0.251024132377292 1164 41905075
SGTC_1293 1000-1278 195 µM 0.670987427772355 0.235157953226367 no 809 0.251114269329833 1284 678847
SGTC_1700 st030840 7.9285 µM 0.669715429660719 0.235528924826512 no 810 0.251519606877099 1252 5499307
SGTC_2323 6148992 148.28 µM 0.669156503520583 0.235692034768221 no 811 0.251697824702225 1193 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3145 9085516 49.47 µM 0.66840901893702 0.23591026855485 no 812 0.251936270004658 1246 25236195
SGTC_2732 terfenadine 20 µM 0.668112600393448 0.235996841025294 no 813 0.25203085961701 1232 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1446 4239-0190 62 µM 0.667624273755348 0.23613950064854 no 814 0.252186729544138 1252 1340085
SGTC_3213 9129884 49.47 µM 0.667546102723407 0.236162341924567 no 815 0.252211685827242 1174 17190742
SGTC_3107 9121808 49.47 µM 0.664343591218488 0.237099148981994 no 816 0.253235213646877 1201 662681
SGTC_1382 3002-2117 298 µM 0.664222672933717 0.237134560274755 no 817 0.253273902070018 1281 1497314
SGTC_2977 9011197 71.43 µM 0.663734891159504 0.237277438171585 no 818 0.253430001889579 1270 2704722
SGTC_1703 st026983 48.3 µM 0.663526266081348 0.237338561718604 no 819 0.253496781476574 1256 1104023
SGTC_2292 7671323 168.05 µM 0.661584880785996 0.237907768493137 no 820 0.254118649880901 1240 937504
SGTC_1738 st035555 74 µM 0.661317626054748 0.237986185133227 no 821 0.254204320063551 1258 5331140
SGTC_3283 9109332 35.8195 µM 0.661283329235626 0.237996249372092 no 822 0.254215315220723 1154 17027281
SGTC_421 streptovitacin 30 mM 0.661277723157717 0.237997894471244 no 823 0.254217112487134 1286 91467 include heat shock
SGTC_773 4358-1457 44.6 µM 0.661259652522688 0.238003197327305 no 824 0.254222905842155 1267 1186886
SGTC_2664 lyso-paf C-16 73.48 µM 0.660893490082753 0.238110662218298 no 825 0.254340310596903 1252 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2512 diallyl trisulfide 49.23 µM 0.660254628454748 0.238298225157122 no 826 0.254545220482422 1259 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_828 2074-0507 139 µM 0.659583386388917 0.238495381797675 no 827 0.254760609275249 1291 X828
SGTC_1530 rhein 70.4 µM 0.658576157249269 0.238791391732048 no 828 0.255083988848846 1284 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_757 1066-0008 322 µM 0.655680219443928 0.239643584064951 no 829 0.256014949319643 1290 6842497
SGTC_1031 k035-0009 16 µM 0.654939244401986 0.239861898388539 no 830 0.256253435883928 1273 5180959
SGTC_398 bronopol 33.3 µM 0.653096413204322 0.240405323959322 no 831 0.256847062238084 1202 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2263 7948595 193.29 µM 0.650144619321449 0.241277162942749 no 832 0.257799404957795 1261 2971371
SGTC_1570 verbenone 133 µM 0.649758953968221 0.241391199461535 no 833 0.257923968109962 1285 29025 A natural terpanoid with antifungal properties.
SGTC_54 0159-0055 9 µM 0.649338018774619 0.241515698251987 no 834 0.258059958433378 1331 3319099
SGTC_2417 cerulenin 830 nM 0.648803596825498 0.24167381292151 no 835 0.258232666155282 1339 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2420 aureobasidin a 50 nM 0.647812164431952 0.241967287964593 no 836 0.258553223328687 1372 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2027 5150920 200 µM 0.645802028444042 0.242562903450424 no 837 0.259203787090802 1249 786715
SGTC_1761 st044296 37 µM 0.644351492460425 0.242993198770201 no 838 0.259673765996948 1271 1826700
SGTC_2991 9074669 71.4286 µM 0.644282051915011 0.243013808363478 no 839 0.259696276012369 1295 17333109
SGTC_2955 9076254 12.21 µM 0.644099618089216 0.243067958280269 no 840 0.259755419001646 1208 16459619
SGTC_2949 9072542 2.23 µM 0.643096798465782 0.243365731186244 no 841 0.260080645887842 1284 16457352
SGTC_1397 3532-0190 20.1 µM 0.642824675318756 0.243446568242506 no 842 0.260168935011103 1223 5322280
SGTC_131 0141-0277 33.849 µM 0.642483694532241 0.243547880661908 no 843 0.260279586485847 1264 1547771
SGTC_2528 xanthyletin 44.79 µM 0.640959822236876 0.244000932696792 no 844 0.260774393560952 1326 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_368 fentichlor 4.58 µM 0.640583947748024 0.24411275122585 no 845 0.26089651579242 1256 7329 A pesticide.
SGTC_933 2914-0560 114 µM 0.640056136614844 0.244269815873709 no 846 0.261068052125548 1315 463887
SGTC_3304 9125678 46.087 µM 0.639227648300816 0.244516465070165 no 847 0.261337424120831 1277 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_334 1502-1024 68.5 µM 0.638173624431911 0.244830452259462 no 848 0.261680332248802 1300 3296216
SGTC_1496 4469-0713 57.4 µM 0.635692983297286 0.245570275498971 no 849 0.262488275340846 1279 746691
SGTC_2919 7978188 46.38 µM 0.634311090760364 0.245982929583499 no 850 0.26293890996628 1275 2980291
SGTC_1148 3909-7663 27.7 µM 0.63296925733846 0.246383977168341 no 851 0.263376859493855 1353 4084526
SGTC_648 0375-0473 33.3 µM 0.626096133592956 0.248443701715604 no 852 0.265625944046135 1311 1713139
SGTC_2488 5268135 45.7 µM 0.62595007473826 0.248487571708968 no 853 0.265673844197173 1338 1270356 YLR208W SEC13
SGTC_1302 1159-0335 255 µM 0.624981405645704 0.248778623975814 no 854 0.265991631025473 1301 649284
SGTC_34 0469-0683 81.75 µM 0.620526967502003 0.250119364993138 no 855 0.267455452562341 1310 3690923
SGTC_74 000s-0487 160.283 µM 0.619991410789759 0.250280819892873 no 856 0.267631720906758 1245 677548
SGTC_1587 estradiol valerate 56.1 µM 0.618117548648302 0.250846169920717 no 857 0.26824892765152 1299 13791 A steroid.
SGTC_1300 1094-0077 113 µM 0.61749724862995 0.251033465187291 no 858 0.268453397746003 1276 5532636
SGTC_705 1124-0212 310 µM 0.616290098724151 0.251398167688392 no 859 0.268851536247029 1331 9554485
SGTC_1312 1218-2183 165 µM 0.616111784853857 0.251452063363774 no 860 0.268910372309802 1324 6744073
SGTC_2693 st077581 40.7 µM 0.615389774425443 0.251670354667119 no 861 0.269148671390077 1325 25238761
SGTC_1360 1598-0022 39.8 µM 0.615118980696673 0.251752251745551 no 862 0.26923807399977 1379 761525
SGTC_3007 9078383 71.4286 µM 0.61439233757234 0.251972082450179 no 863 0.269478048978298 1307 6496995
SGTC_1285 0929-0069 65.5 µM 0.614101136236756 0.252060207756876 no 864 0.269574248736146 1320 1206237
SGTC_1356 1502-0781 85.8 µM 0.613104010974235 0.252362087633971 no 865 0.269903784136023 1292 567702
SGTC_583 1488-1091 88.9 µM 0.612053947585162 0.252680200447607 no 866 0.270251032665563 1399 4303273
SGTC_571 k831-0106 44.2 µM 0.612006996018149 0.252694429181758 no 867 0.270266564432382 1352 4783639
SGTC_1344 1488-0097 29.1 µM 0.611955328794703 0.252710087489439 no 868 0.270283656673072 1335 747966
SGTC_143 4032-1194 15.74 µM 0.610796959545097 0.253061277847626 no 869 0.27066700326229 1348 1806963
SGTC_3013 9080133 71.4286 µM 0.610511269200762 0.253147931906249 no 870 0.270761590329183 1404 17050193
SGTC_1573 oleylamine 1.06 µM 0.610234682658837 0.253231839514535 no 871 0.270853179005459 1333 5356789 An amine of the fatty acid oleic acid.
SGTC_797 k781-0471 270 µM 0.609474649577817 0.253462484797054 no 872 0.271104935431001 1354 23738129
SGTC_1440 4100-1550 40 µM 0.608104905592968 0.253878436062261 no 873 0.271558949437977 1331 742806
SGTC_1539 benzyladenosine 56 µM 0.605476038496855 0.254677748816413 no 874 0.272431370535033 1307 92208 A nucleotide analog.
SGTC_1408 3909-7976 48.8 µM 0.603597822587235 0.255249630536232 no 875 0.273055530409316 1355 24152374
SGTC_3095 9117207 49.47 µM 0.603272048705938 0.255348890889125 no 876 0.273163862143076 1308 17015229
SGTC_1739 st037196 92.5 µM 0.602796102864273 0.255493943539869 no 877 0.273322169823244 1365 612214
SGTC_1803 st050068 52.4 µM 0.602529896296069 0.255575093322137 no 878 0.273410734464848 1413 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_967 1306-0166 352 µM 0.602218424506616 0.255670058736431 no 879 0.273514376492536 1336 4437607
SGTC_1348 1493-0373 93.8 µM 0.601848164068414 0.255782972336173 no 880 0.273637605696047 1350 3010129
SGTC_425 3825-7017 13.1 µM 0.601301243048669 0.255949807471672 no 881 0.273819680898282 1411 3397440
SGTC_355 1311-2252 105 µM 0.600790742890531 0.256105583848988 no 882 0.273989685288988 1304 5338538
SGTC_2659 sanguinarine 24.21 µM 0.60028439028917 0.256260143453302 no 883 0.274158359994862 1292 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2926 9010726 65.15 µM 0.600266345400724 0.256265652391346 no 884 0.27416437200203 1308 2994293
SGTC_1022 4477-0945 21.3 µM 0.600102298864752 0.256315737117701 no 885 0.274219030297693 1331 4648966
SGTC_108 0509-0257 621.132 µM 0.599672075709404 0.256447111937928 no 886 0.274362400940259 1309 536624
SGTC_2379 9035213 200 µM 0.598713648183622 0.256739907638682 no 887 0.274681927163673 1442 646551
SGTC_2172 5754775 163.918 µM 0.598240658375243 0.256884468205303 no 888 0.274839682897893 1270 2263357
SGTC_3123 9126162 49.47 µM 0.597995351431486 0.256959458401944 no 889 0.274921517417065 1391 25239884
SGTC_1345 1488-0192 31.4 µM 0.597199956093219 0.25720268862719 no 890 0.275186944256187 1346 658348
SGTC_1371 2421-0008 32.7 µM 0.595235433968434 0.257803947883849 no 891 0.27584305388656 1362 2827552
SGTC_3101 9120531 49.47 µM 0.59508049703535 0.257851398708978 no 892 0.275894832288688 1391 24824904
SGTC_45 0kpi-0036 14.9 µM 0.593878710235527 0.258219610548596 no 893 0.276296619714193 1358 2795021
SGTC_871 0574-0004 149 µM 0.592230431306585 0.258725064673462 no 894 0.276848147092383 1367 9551173
SGTC_1508 1080-0625 72.9 µM 0.591721389297902 0.25888126874418 no 895 0.277018585547675 1307 767111
SGTC_958 1222-0007 33 µM 0.590817641207251 0.259158712049293 no 896 0.277321306758479 1438 7312461
SGTC_2148 5546263 113.568 µM 0.589133953515163 0.259676000084138 no 897 0.277885709112413 1347 792097
SGTC_2931 9014674 55.67 µM 0.587939931722608 0.260043168276735 no 898 0.278286306181565 1333 2996810
SGTC_2629 bisabolol 100 µM 0.585541982107298 0.260781358607065 no 899 0.279091673249631 1409 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_966 1300-0360 30.2 µM 0.581881332014827 0.261910337147614 no 900 0.280323307814796 1365 70588
SGTC_2462 5162487 171.77 µM 0.581263056315704 0.26210126622912 no 901 0.280531587709096 1343 2259986
SGTC_61 0978-8327 98.565 µM 0.580613151515796 0.26230203953216 no 902 0.280750603275186 1383 6150059 YHR072W ERG7
SGTC_2369 9071472 200 µM 0.580594449527034 0.262307818251941 no 903 0.280756907001578 1417 17296037
SGTC_3246 9135460 32.98 µM 0.579041085331024 0.262788019137682 no 904 0.281280725572294 1359 41446951
SGTC_2208 7283366 200 µM 0.578076228090647 0.263086517513683 no 905 0.281606327819005 1405 898663
SGTC_1391 3442-0225 151 µM 0.578045053749495 0.263096164824159 no 906 0.281616850991944 1359 5227075
SGTC_90 0870-0863 4.608 µM 0.576210914379621 0.263664081423299 no 907 0.282236314417419 1347 1738164
SGTC_2866 9034245 58.44 µM 0.575768647792161 0.263801116844496 no 908 0.282385783891719 1369 6462273
SGTC_3271 9137798 49.47 µM 0.575620399589987 0.263847059380431 no 909 0.282435894728349 1347 6498326
SGTC_1418 3966-3099 2.4 µM 0.574882129873972 0.264075911973314 no 910 0.282685508215351 1418 740335
SGTC_771 0250-0039 27.3 µM 0.574346660839364 0.264241962637585 no 911 0.282866619861407 1387 3005115
SGTC_973 1325-0077 65.9 µM 0.573505782270144 0.264502829045372 no 912 0.283151142565573 1460 2835149
SGTC_2786 7743617 45.45 µM 0.572433861518055 0.26483556174481 no 913 0.283514040506348 1303 583674
SGTC_2728 chlorpromazine 9.18 µM 0.571345598398045 0.265173584772453 no 914 0.283882699005288 1374 2726 A thorazine and dopamine antagonist.
SGTC_2890 9046729 58.44 µM 0.571321400453138 0.265181103332424 no 915 0.283890898874393 1320 903329
SGTC_2768 sulfasalazine 50.2 µM 0.569555366768638 0.26573012096038 no 916 0.284489654089848 1493 5384001 An antioxidant and salicylic acid derivative.
SGTC_2777 climbazole 1.536 µM 0.56924923989272 0.265825347051952 no 917 0.284593504512053 1393 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2400 5203494 178.7 µM 0.568374036645736 0.266097689624347 no 918 0.284890508108192 1352 6777674
SGTC_264 promethazine 12.5 mM 0.567388989953354 0.266404381803102 no 919 0.285224964257027 1394 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_290 2043-6722 48.1 µM 0.567355127004298 0.26641492813859 no 920 0.285236465181359 1403 773758 YLR208W SEC13
SGTC_1008 4106-0037 6 µM 0.566564277108496 0.266661291855423 no 921 0.28550512554197 1382 2905394
SGTC_3116 9124943 49.47 µM 0.56643022160021 0.266703063928329 no 922 0.285550677602285 1298 41905195 YPL160W CDC60
SGTC_285 1486-1325 46 µM 0.566420793307871 0.266706001935195 no 923 0.285553881466125 1418 22310230
SGTC_2268 7933382 153.85 µM 0.564787799047632 0.267215115775213 no 924 0.286109053401594 1377 935025 YOR257W CDC31
SGTC_869 0564-0080 44.1 µM 0.564397657214119 0.267336821702385 no 925 0.286241766459319 1365 6843321
SGTC_2030 5175110 200 µM 0.563161792920707 0.267722537831966 no 926 0.286662358555449 1434 2831986
SGTC_2266 7929956 200 µM 0.562192519697459 0.268025246365325 no 927 0.28699242869805 1381 2967153
SGTC_1459 k035-0031 35.7 µM 0.5610990418513 0.268366951307688 no 928 0.287365010650985 1293 3877128 YMR208W ERG12
SGTC_2670 beta-carotene 100 µM 0.558720109107759 0.269111108853719 no 929 0.28817637659464 1339 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_167 3672-0051 66.205 µM 0.558268138157621 0.26925260752671 no 930 0.28833064924996 1348 3237971
SGTC_1271 0832-2808 169 µM 0.557796790514147 0.269400212206471 no 931 0.288491577282646 1423 3663794
SGTC_2425 5628681 7.85 µM 0.556817597875793 0.269706980497941 no 932 0.288826029552581 1433 5714958
SGTC_2288 7946289 167.31 µM 0.556488324473141 0.269810176858811 no 933 0.288938536910233 1503 1246052
SGTC_2625 euphol 100 µM 0.554986440211714 0.270281127463862 no 934 0.289451967657335 1477 6708538 A triterpene alcohol.
SGTC_3043 9092303 49.47 µM 0.554056519104891 0.270572931652673 no 935 0.289770083040566 1338 25236084
SGTC_1993 st073995 70.8 µM 0.552190038653424 0.271159097601248 no 936 0.290409079242226 1438 3098394
SGTC_2927 9011802 47.9 µM 0.551567650713296 0.271354698463614 no 937 0.290622302531323 1345 43912568
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.550234765134482 0.271773827230902 no 938 0.291079180726459 1439 5393153
SGTC_2690 usnic acid 100 µM 0.549802025684077 0.271909972338449 no 939 0.291227584559487 1545 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3329 9141233 27.5565 µM 0.547315812787165 0.272692822030065 no 940 0.292080891013881 1492 4909101 YNL103W MET4
SGTC_3034 9090421 49.47 µM 0.546554021680977 0.272932915710036 no 941 0.292342582147036 1386 17173761
SGTC_385 1494-0393 12.4 µM 0.545767464876307 0.273180924734808 no 942 0.29261289516532 1438 3090647
SGTC_856 0433-0016 11.3 µM 0.543031398734061 0.274044501872045 no 943 0.29355409203399 1430 3911780
SGTC_3348 9149464 3.537 µM 0.542653162323007 0.27416398965103 no 944 0.293684314207407 1405 1951442
SGTC_2375 9072683 200 µM 0.542418867137549 0.274238018199954 no 945 0.293764992584556 1531 16798029
SGTC_3008 9078912 71.4286 µM 0.541759948906096 0.274446264713572 no 946 0.293991942745473 1402 16648731
SGTC_81 0411-0046 9.971 µM 0.541568704050315 0.274506720926338 no 947 0.294057828082864 1332 12925265
SGTC_1833 st055984 71 µM 0.541312309077242 0.274587782665274 no 948 0.294146168848481 1413 676288
SGTC_1695 st026914 34.495 µM 0.539983567011685 0.275008066329916 no 949 0.294604182631028 1380 3289191
SGTC_674 0498-0004 451 µM 0.539467952695594 0.275171241432277 no 950 0.294782002052205 1378 4231473
SGTC_451 chloral hydrate 100 µM 0.538823859177112 0.275375142956382 no 951 0.295004199464475 1462 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3196 9111891 49.47 µM 0.538366670908645 0.275519920743548 no 952 0.295161965682245 1401 18891510
SGTC_1341 1486-1360 280 µM 0.538337612882295 0.275529123812546 no 953 0.295171994319159 1403 3976547
SGTC_473 2-arachidonoylglycerol 10 µM 0.537883739758356 0.275672891175097 no 954 0.295328657414019 1393 5282280 An endocannabinoid.
SGTC_3327 9140648 26.9345 µM 0.537200477660962 0.275889388557842 no 955 0.295564570680829 1450 8029710
SGTC_1132 3456-3614 2.5 µM 0.535065529480099 0.276566402734111 no 956 0.296302272487406 1627 3125502
SGTC_2740 felodipine 17.08 µM 0.534323938326108 0.276801759397075 no 957 0.29655871648482 1500 3333 L-type calcium channel blocker
SGTC_2859 9028643 45.46 µM 0.531107406687953 0.277823714959104 no 958 0.297672175959156 1408 17151580
SGTC_2827 7993847 71.43 µM 0.530850530448017 0.277905408972595 no 959 0.297761180424825 1450 2985692
SGTC_1250 0485-0349 40.2 µM 0.530600503148829 0.277984936085234 no 960 0.297847823473202 1441 6842794 YDL195W SEC31
SGTC_3051 9093778 49.47 µM 0.529462821964404 0.278346942736827 no 961 0.298242214183134 1441 17217378
SGTC_2057 5236571 38.335 µM 0.528886409171925 0.278530443172495 no 962 0.298442125255117 1512 54684039 YBR257W POP4
SGTC_779 1360-0071 233 µM 0.527858174573357 0.278857926872898 no 963 0.298798888158276 1602 7566
SGTC_2751 anetholtrithion 17.25 µM 0.527070723508173 0.279108849751072 no 964 0.299072238234712 1505 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.525803590359936 0.279512854607776 no 965 0.299512339849306 1462 4213774
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.521707202524739 0.280820860837695 no 966 0.300937104540848 1350 641818 YHR062C RPP1
SGTC_3173 9105693 49.47 µM 0.521421033328373 0.28091234721014 no 967 0.301036751161244 1480 17096658
SGTC_1169 aniline yellow 25.8 µM 0.519331746558241 0.281580714356461 no 968 0.301764709317568 1486 6051 A DNA damaging agent.
SGTC_1471 k673-0312 37 µM 0.519073874265463 0.281663261378679 no 969 0.30185461311298 1437 24099884
SGTC_2981 9013952 38.96 µM 0.517510006418614 0.282164118009776 no 970 0.302400092787984 1348 2996344
SGTC_1722 st034304 3.6505 µM 0.517432783083928 0.28218886126675 no 971 0.302427039864638 1435 4036148 YLR033W RSC58
SGTC_2219 9098279 200 µM 0.515483623744348 0.282813740258264 no 972 0.303107555136173 1481 902349
SGTC_1512 0259-0544 12.2 µM 0.514340468694083 0.283180532119718 no 973 0.303506986332428 1510 18476
SGTC_503 tyrphostin 8 294 µM 0.51428392292375 0.283198681274795 no 974 0.303526750159552 1501 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1076 itraconazole 331 nM 0.513205276052485 0.283544994863786 no 975 0.303903867848862 1456 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1840 st055363 71 µM 0.512848644409499 0.28365954070785 no 976 0.304028599740722 1390 676033
SGTC_2667 digitoxin 100 µM 0.510599662221276 0.284382397203525 no 977 0.30481570622142 1465 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_813 k007-0158 173 µM 0.510370941858514 0.2844559606305 no 978 0.304895805270108 1563 6523916
SGTC_175 3793-3120 23.7 µM 0.508778797330419 0.284968294482996 no 979 0.305453641408803 1454 5322297
SGTC_3286 9117135 37.221 µM 0.508263799189498 0.285134109125293 no 980 0.305634176973736 1412 3438150
SGTC_766 1391-0721 126 µM 0.507878960823086 0.285258046065217 no 981 0.305769115136144 1574 1020919 YIL115C NUP159
SGTC_2093 5331342 194.4 µM 0.507869882566687 0.285260970021502 no 982 0.305772298617615 1520 33839
SGTC_893 0958-0369 48.9 µM 0.507267001282676 0.285455180069738 no 983 0.305983744458806 1569 6819948
SGTC_1564 D-Arginine 115 µM 0.505965021468562 0.285874809901775 no 984 0.306440602559857 1388 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2916 7875993 68.79 µM 0.505565423876979 0.286003659536802 no 985 0.30658087972988 1574 1299250
SGTC_25 0118-0223 35.662 µM 0.504710143915262 0.286279535978476 no 986 0.30688121764055 1528 5333628
SGTC_1711 st032263 62.8 µM 0.502480718162433 0.286999245934646 no 987 0.307664706195809 1518 3958979
SGTC_1086 cerivastatin 2.18 µM 0.501181777985048 0.28741896847449 no 988 0.308121598669652 1499 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1206 3978-0017 132 µM 0.500559795869916 0.28762005038285 no 989 0.308340481599644 1551 3873677
SGTC_2243 6634756 200 µM 0.500238812204883 0.287723847873697 no 990 0.308453466249322 1574 885676
SGTC_970 1315-0089 19.5 µM 0.49918244648775 0.288065573070286 no 991 0.308825429775933 1418 6811083 YLR033W RSC58
SGTC_1812 st052057 4.327 µM 0.498246683715167 0.288368444153051 no 992 0.309155090931927 1440 3645418
SGTC_3096 9117468 49.47 µM 0.497639267349431 0.288565122219697 no 993 0.309369160778572 1420 41316311
SGTC_3168 9103419 49.47 µM 0.497454580490802 0.288624935332143 no 994 0.309434262222546 1470 16649256
SGTC_3237 9133362 49.47 µM 0.495677034811303 0.289200913755727 no 995 0.310061146167053 1537 43845137
SGTC_2265 7929201 200 µM 0.49422189710101 0.289672824133451 no 996 0.310574738453999 1429 1265108
SGTC_3001 9076041 71.4286 µM 0.493814806952916 0.289804910718612 no 997 0.31071848750106 1471 16004211
SGTC_2742 clothiapine 36.27 µM 0.493788261683303 0.289813524715991 no 998 0.310727861999324 1557 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3165 9101544 49.47 µM 0.493604477202928 0.28987316647154 no 999 0.310792769110041 1509 5002184
SGTC_1122 capsaicin 818.572 nM 0.491705083510517 0.290489894804978 no 1000 0.311463922017934 1586 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.490332016289138 0.290936108351994 no 1001 0.311949487504325 1455 6312947
SGTC_133 0724-0033 378.92 µM 0.487346713995654 0.291907362831547 no 1002 0.313006324239416 1412 280309
SGTC_3133 9127736 49.47 µM 0.487281044091833 0.291928745199803 no 1003 0.313029589581614 1555 27243420
SGTC_1450 4112-4260 37.6 µM 0.487077569607808 0.291995001889806 no 1004 0.31310168065576 1565 1633175
SGTC_2168 5727979 200 µM 0.48672250772341 0.292110636224395 no 1005 0.313227496305149 1425 695210
SGTC_2575 plumbagin 510 nM 0.486362502383793 0.292227902267446 no 1006 0.313355085861614 1433 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2196 6573537 42.6665 µM 0.48598094078067 0.292352213823628 no 1007 0.313490339565725 1583 2903087
SGTC_78 0336-0123 156.75 µM 0.485559373565914 0.292489587666901 no 1008 0.313639803387492 1453 6765896
SGTC_2025 5147754 141 µM 0.483891089273144 0.293033516577264 no 1009 0.314231582302525 1551 315777 YLR208W SEC13
SGTC_971 1315-0384 26.7 µM 0.483492201214008 0.293163639877778 no 1010 0.31437314794046 1475 6769120
SGTC_291 SEC14.278 35.5 µM 0.481893700359467 0.293685363591904 no 1011 0.314940730742763 1593 1068044
SGTC_2648 atorvastatin 78.68 µM 0.481193343664633 0.293914083512143 no 1012 0.31518954561591 1583 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1119 parthenolide 318.541 nM 0.480910985510872 0.294006318297228 no 1013 0.31528988238166 1621 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1021 4476-0760 85.3 µM 0.480097295662411 0.294272192091141 no 1014 0.315579105551146 1473 746768
SGTC_2841 9004761 38.96 µM 0.47958957536539 0.294438146340565 no 1015 0.315759630194504 1408 2991039
SGTC_467 ro 31-8220 72.8 µM 0.478370317849811 0.294836851097168 no 1016 0.316193327953265 1544 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1465 k213-0056 144 µM 0.476560272578962 0.295429205633528 no 1017 0.316837639220018 1484 24048857 YMR208W ERG12
SGTC_1696 st025591 34.7925 µM 0.475662957585023 0.295723063323302 no 1018 0.317157257455693 1524 2787147
SGTC_1661 st013063 9.66 µM 0.475270807507776 0.295851528966929 no 1019 0.31729698182625 1539 721395
SGTC_1766 st045414 44.774 µM 0.473921225755811 0.296293838357407 no 1020 0.317778041213437 1521 253960
SGTC_3350 9150499 3.57 µM 0.473474073617846 0.296440454012171 no 1021 0.317937496830212 1483 4910996 YPR165W RHO1
SGTC_2020 4017018 200 µM 0.472233525831379 0.296847388277843 no 1022 0.318380056093308 1515 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1053 3366-3204 134 µM 0.472136438728676 0.29687924633903 no 1023 0.318414702384353 1480 3632071 YPR165W RHO1
SGTC_2204 7233102 200 µM 0.471561180945059 0.297068042923421 no 1024 0.318620020193267 1540 2172480
SGTC_259 usnic acid 108.925 µM 0.471410220975732 0.297117596286013 no 1025 0.318673909215112 1565 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_176 1486-1328 72.834 µM 0.470933460610941 0.297274120063185 no 1026 0.31884412619788 1500 22310231
SGTC_1758 st042942 75.2445 µM 0.470450857438101 0.297432600440306 no 1027 0.319016468156154 1504 669317
SGTC_781 4335-2806 94.4 µM 0.470115040097754 0.297542901090075 no 1028 0.319136414657278 1652 845254
SGTC_2249 haloperidol 116.36 µM 0.469627272850294 0.297703143591105 no 1029 0.319310668019941 1569 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1927 st060202 13.8 µM 0.468075960111874 0.298213046245188 no 1030 0.31986513499608 1571 688887
SGTC_3203 9113543 49.47 µM 0.467536011954015 0.298390615651765 no 1031 0.320058216686931 1578 17018012
SGTC_694 1315-0438 43.2 µM 0.46673434268376 0.298654344384188 no 1032 0.320344977926172 1577 6793154
SGTC_3162 9099653 49.47 µM 0.466665738532133 0.298676918321624 no 1033 0.320369522972499 1530 25237511
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.46636081674175 0.298777261072346 no 1034 0.320478626744213 1466 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.466291838017436 0.29879996250945 no 1035 0.320503310107328 1633 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1690 st023502 41.2 µM 0.465807845757591 0.298959270184685 no 1036 0.320676524336292 1596 24207482
SGTC_2363 9053361 176 µM 0.465618017428614 0.29902176334641 no 1037 0.320744471970975 1635 6469797 YMR079W SEC14
SGTC_2657 nystatin 74.44 µM 0.465004861457728 0.299223660217507 no 1038 0.320963987599137 1575 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2011 4012611 177 µM 0.464983166483819 0.299230804960762 no 1039 0.32097175575167 1497 2049887
SGTC_2197 6588183 93.1375 µM 0.463576971223153 0.299694068205107 no 1040 0.321475428299606 1524 884136
SGTC_1190 1486-1332 13 µM 0.459872944726242 0.300915891307028 no 1041 0.322803710486951 1501 4150046
SGTC_3012 9080433 71.4286 µM 0.459580397072284 0.301012487740403 no 1042 0.322908716197087 1633 17688859
SGTC_1091 telmisartan 47.6 µM 0.459379400822631 0.301078862876906 no 1043 0.322980869050021 1620 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_542 3381-0244 89.3 µM 0.458565174845761 0.301347812765218 no 1044 0.323273224864981 1644 1112843
SGTC_141 0443-0274 32.331 µM 0.457948739378199 0.301551501681223 no 1045 0.323494634685679 1594 1627241
SGTC_1480 1070-0044 41.2 µM 0.457539864103951 0.301686640592333 no 1046 0.323641528018307 1591 3124987
SGTC_1719 st032227 49.2 µM 0.457327148013241 0.301756956958429 no 1047 0.323717959687476 1502 3125804
SGTC_939 1165-0479 45.3 µM 0.457159361567642 0.301812426380782 no 1048 0.323778252794299 1531 1377347
SGTC_1138 3761-0006 1.03 µM 0.457118306097876 0.30182599982693 no 1049 0.323793006548662 1563 12061087
SGTC_1340 1486-1359 257 µM 0.456926204884738 0.301889514509075 no 1050 0.32386204400339 1559 4309068
SGTC_2593 nobiletin 86.24 µM 0.455398786274662 0.302394740539095 no 1051 0.32441118415004 1506 72344 An anti-infammatory.
SGTC_1316 1272-0050 65.9 µM 0.448754747530952 0.304596795063687 no 1052 0.326804293072313 1550 7340392
SGTC_465 cgp-37157 41 µM 0.446897013764311 0.305213783244056 no 1053 0.327474710108597 1615 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1611 st001856 99.4 µM 0.446463644148673 0.305357793154657 no 1054 0.327631184252564 1516 647478
SGTC_2987 9018338 71.43 µM 0.446080174073515 0.305485246437605 no 1055 0.327769666721612 1570 5055682
SGTC_852 0418-0143 439 µM 0.445310854464007 0.305741014948987 no 1056 0.328047562376616 1588 5369229
SGTC_1634 st006576 41 µM 0.443452869017249 0.30635911277689 no 1057 0.328719101192099 1700 3915356
SGTC_523 1934-0222 13.7 µM 0.441851447243767 0.306892301903064 no 1058 0.329298353435591 1538 1361595
SGTC_775 4577-0580 57.3 µM 0.439852707236721 0.307558350488252 no 1059 0.330021895236395 1625 2006902
SGTC_722 3534-0461 190 µM 0.439667343118529 0.307620152361688 no 1060 0.330089029135751 1550 658262
SGTC_75 0159-0059 199.013 µM 0.438684422046623 0.307947957285174 no 1061 0.330445108105087 1669 5377270
SGTC_2893 9048488 25.97 µM 0.436558356192175 0.30865752605509 no 1062 0.331215834629806 1501 6467338
SGTC_277 nystatin 15.5 µM 0.435900741201514 0.308877148207498 no 1063 0.331454373668725 1537 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2811 7967822 32.47 µM 0.434196554838367 0.309446609321337 no 1064 0.332072857330172 1662 2232244
SGTC_945 3381-0768 11.3 µM 0.434157642355105 0.309459617444879 no 1065 0.332086984808181 1592 1126236 YIL048W NEO1
SGTC_96 0929-0093 37.281 µM 0.431573804025055 0.310323906984419 no 1066 0.333025600546195 1537 6991579
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.4302717767249 0.310759830547214 no 1067 0.333498977481276 1551 390807
SGTC_3274 9138298 49.47 µM 0.429395026245568 0.311053519641337 no 1068 0.333817886386966 1549 17015756
SGTC_516 3992-2719 87.3 µM 0.428725721981008 0.311277800561127 no 1069 0.334061419716723 1484 5350887 YDR037W KRS1
SGTC_2304 7443016 91.4 µM 0.428262597019479 0.311433032728793 no 1070 0.334229973476852 1566 939854
SGTC_1218 1348-1416 30.7 µM 0.427435550899601 0.311710328908676 no 1071 0.334531059040699 1581 6787668
SGTC_2891 9063876 19.48 µM 0.427006323023271 0.311854284695242 no 1072 0.334687361122122 1639 6472478
SGTC_397 arbidol 50 µM 0.425131190645806 0.312483509349317 no 1073 0.335370520779577 1673 131410 A RNA synthesis inhibitor.
SGTC_124 0136-0217 7.121 µM 0.423105085009756 0.313164009984173 no 1074 0.336109296255094 1683 3976905
SGTC_475 α-linolenic acid 10 µM 0.422309591992671 0.313431363520324 no 1075 0.336399528883359 1669 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_476 mead acid 10 µM 0.421349226342439 0.313754258976753 no 1076 0.3367500445865 1616 5312531 An omega 9 fatty acid.
SGTC_2692 st077426 47.7 µM 0.420787867326697 0.313943065982148 no 1077 0.336954995960914 1672 25238571
SGTC_2847 9005661 71.43 µM 0.420328508430302 0.31409760260502 no 1078 0.337122743260647 1580 2991449
SGTC_2823 7987624 58.44 µM 0.417245512520217 0.315135620657189 no 1079 0.338249419235444 1595 2239440
SGTC_1554 st069299 38.7 µM 0.416513593742692 0.315382266342011 no 1080 0.338517111141672 1636 24207999
SGTC_3305 9127027 53.8275 µM 0.414199706785173 0.316162552553321 no 1081 0.339363928267943 1610 41905295
SGTC_2763 lisinopril 49.32 µM 0.412572386648722 0.316711806589866 no 1082 0.339959967932569 1621 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_439 amiodarone 34.4 µM 0.412136909831917 0.316858857604848 no 1083 0.340119538275041 1682 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_492 tmb-8 126 µM 0.411581007916927 0.317046615593211 no 1084 0.34032327720556 1659 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_984 1492-0255 2.91 µM 0.410244533453778 0.317498207658042 no 1085 0.34081328788249 1641 1585198
SGTC_2160 5660466 132.927 µM 0.409877469155676 0.317622285549896 no 1086 0.340947916967902 1693 2859134
SGTC_2583 asiatic acid 100 µM 0.409337444382705 0.317804866110858 no 1087 0.341146020015305 1633 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_483 fpl-64176 144 µM 0.409326619566422 0.317808526397986 no 1088 0.341149991446025 1629 3423
SGTC_896 0964-0007 44.5 µM 0.409280568240111 0.317824098323306 no 1089 0.341166887047403 1670 6756758
SGTC_2505 galangin 7.89 µM 0.408370892721899 0.318131764580653 no 1090 0.34150069978226 1566 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1233 0325-0408 14.2 µM 0.408326707548651 0.318146711884603 no 1091 0.341516917046707 1683 12874
SGTC_309 k408-0051 1.48 µM 0.40775490789367 0.318340171426407 no 1092 0.341726810803267 1630 3640463
SGTC_2391 6285546 200 µM 0.406640175784224 0.318717466174512 no 1093 0.342136142531593 1583 846083
SGTC_1236 0330-0013 258 µM 0.405651787884576 0.319052155441875 no 1094 0.34249923567153 1610 4617066
SGTC_244 nsc-207895 1.295 µM 0.402470493001824 0.320130410686609 no 1095 0.343668899897284 1559 42640
SGTC_1967 st070177 51.4 µM 0.401794525461795 0.320359716614557 no 1096 0.343917625733512 1675 5729214
SGTC_38 0929-0051 58.268 µM 0.400901080704441 0.320662901778323 no 1097 0.344246477113062 1778 1379719
SGTC_2913 7966556 36.57 µM 0.400315082908486 0.320861821648992 no 1098 0.344462230076542 1728 2976516
SGTC_2078 5212016 200 µM 0.400235921236762 0.320888697417602 no 1099 0.344491379742887 1717 1899708
SGTC_2748 diazoxide 86.69 µM 0.399600564476059 0.321104438083789 no 1100 0.344725370314241 1675 3019 A potassium channel activatior.
SGTC_2807 7945238 51.95 µM 0.398368226873418 0.321523060690595 no 1101 0.345179387601177 1663 17148797
SGTC_2348 9022543 33.42 µM 0.395203782671397 0.322599053792327 no 1102 0.346346250635799 1660 3162678 YDL140C RPO21
SGTC_1188 1403-0014 4.57 µM 0.394582177012287 0.322810590902004 no 1103 0.346575634559749 1628 9614867
SGTC_2504 purpurogallin 52.29 µM 0.393629712594584 0.323134832989332 no 1104 0.346927220591223 1609 5281571 An antioxidant.
SGTC_364 0083-0097 67.7 µM 0.392162199763293 0.323634673163562 no 1105 0.347469185941505 1657 5207356
SGTC_2479 5617353 43.85 µM 0.39089597796439 0.32406620877741 no 1106 0.347937063521496 1695 2731746
SGTC_1 0258-0098 57.368 µM 0.389871450296911 0.324415546793289 no 1107 0.348315803039326 1623 6790032 YDR047W HEM12
SGTC_1834 st055981 52.8 µM 0.389269351869149 0.324620919263161 no 1108 0.348538452773644 1746 471719 YDL150W RPC53
SGTC_2802 7925815 54.55 µM 0.388827005097671 0.324771835310582 no 1109 0.348702061267723 1609 1262923
SGTC_495 decylubiquinone 155 µM 0.38813294894741 0.325008685360712 no 1110 0.348958824906661 1607 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2898 9056270 58.44 µM 0.388003539583734 0.32505285476511 no 1111 0.349006707101823 1651 19154699
SGTC_1795 st049545 62.3 µM 0.387415582051846 0.325253564661437 no 1112 0.349224284974858 1760 5291882
SGTC_2943 9068529 45.32 µM 0.386912765352239 0.325425250426657 no 1113 0.349410395198519 1648 3270634
SGTC_2855 9016525 58.44 µM 0.38651570049033 0.325560853621376 no 1114 0.349557388520891 1610 43811474
SGTC_3006 9075424 71.4286 µM 0.386257808445664 0.325648939725807 no 1115 0.349652872184221 1591 7465181
SGTC_148 3253-0744 288.01 µM 0.385436606506023 0.325929495889903 no 1116 0.3499569827858 1601 6893655
SGTC_2676 harmalol 100 µM 0.385253317061951 0.325992128522371 no 1117 0.350024872372516 1709 5459187 A monoamine oxidase inhibitor
SGTC_458 nppb 133 µM 0.380915007343067 0.327476021320522 no 1118 0.351633158132766 1795 4549 A chloride channel blocker.
SGTC_2717 st081029 62.2815 µM 0.379357153279437 0.328009543332811 no 1119 0.352211331758154 1748 5292846
SGTC_1951 sophoraflavanone G 9.2 µM 0.37832751327688 0.328362359424778 no 1120 0.352593654520808 1618 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1430 4049-0248 69.1 µM 0.37771664088407 0.32857175314628 no 1121 0.35282055220733 1747 22774488
SGTC_2959 9079155 11 µM 0.373258620894047 0.330101491839008 no 1122 0.354477985164378 1692 16189457
SGTC_704 1310-0270 142 µM 0.372514520883598 0.330357102336622 no 1123 0.35475490129921 1618 5718033
SGTC_1361 1608-0041 5.61 µM 0.371920801519605 0.33056111142596 no 1124 0.354975908485253 1639 X1361
SGTC_2600 tangeritin 87.95 µM 0.369617697253206 0.331352961723464 no 1125 0.355833681515499 1585 68077 A bioactive flavone.
SGTC_1109 tnp00067 928.257 nM 0.36805452716705 0.33189083894822 no 1126 0.356416288297172 1650 676295
SGTC_2250 alverine citrate 130 µM 0.367998063681396 0.331910274180381 no 1127 0.356437338999982 1645 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2254 7938975 95.19 µM 0.366442920464352 0.332445745887766 no 1128 0.357017298837846 1774 2969277
SGTC_1872 amphotericin b 148 nM 0.366307262934955 0.332492472146107 no 1129 0.357067905319086 1757 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_62 0180-0423 3.232 µM 0.364008583305828 0.333284631025651 no 1130 0.357925799950178 1743 30102 YGL099W LSG1
SGTC_2115 tiliquinol 12.7705 µM 0.361332386843472 0.334207825303624 no 1131 0.358925492820605 1702 71208 A bioactive hydroxyquinoline.
SGTC_377 3970-0964 33.1 µM 0.361253733754632 0.33423497308324 no 1132 0.358954888333228 1747 16481235
SGTC_341 1486-1430 230 µM 0.360700546280304 0.334425934914061 no 1133 0.359161658147302 1627 2054753 YPL210C SRP72
SGTC_1400 3771-8998 51.5 µM 0.359139680016393 0.334964981116719 no 1134 0.359745299328366 1748 670767
SGTC_2125 5246583 200 µM 0.357989554514245 0.335362395468411 no 1135 0.360175565264691 1855 835267
SGTC_952 1185-0122 232 µM 0.357962879969967 0.335371614778631 no 1136 0.360185546408497 1646 678600
SGTC_3125 9127534 49.47 µM 0.357900274276305 0.335393253075144 no 1137 0.360208972728735 1687 1639235
SGTC_505 gw-5074 63.9 µM 0.356757306702444 0.335788390884142 no 1138 0.360636750049294 1768 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_46 0329-0187a 2.197 µM 0.356540435152243 0.33586338653216 no 1139 0.36071793805313 1753 46494817
SGTC_678 1218-2179 85.9 µM 0.356416730494561 0.335906167366678 no 1140 0.360764250923859 1733 6820081 YOR116C RPO31
SGTC_1607 st000305 50.6 µM 0.355923307562962 0.336076829178974 no 1141 0.36094900019162 1742 5457690
SGTC_1861 st057647 17.4 µM 0.355327911461381 0.336282805779849 no 1142 0.361171973833766 1829 688668
SGTC_795 0685-0265 78 µM 0.354998201349284 0.33639688976716 no 1143 0.361295469354337 1675 302754
SGTC_1337 1486-1011 40.3 µM 0.353969629757427 0.336752885678938 no 1144 0.361680821784953 1666 X1337
SGTC_1831 st055328 12 µM 0.353773939270105 0.336820632119566 no 1145 0.361754152760843 1803 1103068
SGTC_459 nigericin 15.3 µM 0.353521204501119 0.336908134657092 no 1146 0.361848867417429 1719 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3105 9121040 49.47 µM 0.353121063146894 0.337046690764646 no 1147 0.361998841338492 1727 41448907
SGTC_980 1473-0395 201 µM 0.350863931178363 0.337828676787673 no 1148 0.362845216037067 1673 768876
SGTC_1902 st060212 70.5 µM 0.349524171641696 0.338293169593932 no 1149 0.363347913684563 1682 688944
SGTC_1291 0993-0025 5.79 µM 0.347938570276883 0.338843213517434 no 1150 0.363943158999485 1799 4353356
SGTC_780 0109-0199 192 µM 0.34680703817923 0.339235951457794 no 1151 0.364368144613657 1827 610414
SGTC_646 4092-0839 27.3 µM 0.345022582662476 0.33985566431359 no 1152 0.365038696736523 1792 877796
SGTC_1799 st045822 46.1415 µM 0.341040180246086 0.341240248601693 no 1153 0.366536666767403 1832 3674992
SGTC_2697 mebhydrolin 72.4 µM 0.340422033003343 0.341455355676264 no 1154 0.366769364260039 1849 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1483 3453-0561 55.9 µM 0.337805761211754 0.342366353375876 no 1155 0.367754784017234 1772 4546991
SGTC_67 0335-0847 266 µM 0.336349779942676 0.342873730598256 no 1156 0.368303557655936 1925 4552207 YOR254C SEC63
SGTC_2800 7887935 81.82 µM 0.336284096456452 0.34289662652848 no 1157 0.368328320751625 1760 2961002
SGTC_353 1988-1175 58.3 µM 0.336237862175629 0.342912743206434 no 1158 0.368345751700125 1662 2788357
SGTC_1505 k297-0037 20.6 µM 0.336059867052622 0.342974792694195 no 1159 0.368412860795686 1683 4089396
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.335888825337034 0.343034422199186 no 1160 0.368477352046133 1694 2374 Ca(2+)-ATPase inhibitor.
SGTC_3302 9125395 16.351 µM 0.335789235956996 0.343069143398279 no 1161 0.36851490391218 1735 17599668
SGTC_2147 5545932 89.7195 µM 0.334573391918681 0.343493146392583 no 1162 0.368973459696753 1727 797404
SGTC_618 k072-0232 33.2 µM 0.332283956087008 0.344292078991981 no 1163 0.369837426751362 1747 5872756 YGL099W LSG1
SGTC_1068 loratadine 26.9 µM 0.331160964661917 0.344684217934504 no 1164 0.370261451932805 1702 3957 A H1 histamine antagonist.
SGTC_392 N-ethylmaleimide 8.33 µM 0.32909698161656 0.345405378190676 no 1165 0.371041192806514 1706 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1912 st060209 90.8 µM 0.326787226139631 0.346213077715741 no 1166 0.37191441077345 1669 688787
SGTC_2156 5649887 115 µM 0.325737040827012 0.346580549253455 no 1167 0.372311658408323 1844 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_352 k048-0007 5.11 µM 0.324981369678777 0.346845056371968 no 1168 0.372597585951085 1756 6811911
SGTC_3195 9113082 49.47 µM 0.318989042440538 0.348945181173991 no 1169 0.374867410974964 1894 17018038
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.317171269915094 0.349583173459783 no 1170 0.375556824307728 1927 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3248 9135562 49.47 µM 0.316451562356322 0.349835890224908 no 1171 0.375829892532571 1762 17650701
SGTC_1868 st057644 42.7 µM 0.315036839167311 0.350332847346782 no 1172 0.376366841660593 1728 688665
SGTC_2750 bromebric acid 70.15 µM 0.314855129643009 0.350396695984275 no 1173 0.376435825714202 1769 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1609 st001574 46.4 µM 0.313619519621113 0.350830973570065 no 1174 0.376905016244225 1722 3960012
SGTC_1504 k297-0033 30 µM 0.31303176762277 0.35103761814712 no 1175 0.377128263529965 1690 4388117
SGTC_927 2425-1185 123 µM 0.312392101938865 0.351262564847969 no 1176 0.377371275996663 1701 730375
SGTC_1153 4055-0057 267 µM 0.311620396147496 0.351534014517567 no 1177 0.377664515846068 1726 882706
SGTC_1983 st071813 46.9 µM 0.310798743852587 0.35182311624834 no 1178 0.377976812343813 1773 11838595
SGTC_313 3474-0040 5.03 µM 0.310338494809965 0.351985094219718 no 1179 0.378151780285214 1739 1043375 YIL048W NEO1
SGTC_198 3454-2873 16.191 µM 0.309549807933092 0.35226272356549 no 1180 0.378451665005836 1790 710957
SGTC_1680 diphenhydramine 100 µM 0.30863049379333 0.352586435011123 no 1181 0.378801310919108 1754 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3159 9100096 49.47 µM 0.307234626033392 0.35307815594147 no 1182 0.379332395722509 1736 25236875
SGTC_1677 st019204 53.9 µM 0.307153923994515 0.353106592280384 no 1183 0.379363107344367 1699 3945625
SGTC_3044 9093193 49.47 µM 0.306098191255481 0.353478667978047 no 1184 0.379764942522264 1702 25236277
SGTC_1908 st060353 56.5 µM 0.304745245474037 0.353955696260092 no 1185 0.380280093356164 1949 4227716
SGTC_607 4491-0986 66.8 µM 0.304045852048265 0.354202381805506 no 1186 0.380546479399662 1890 698981 YDR232W HEM1
SGTC_1176 0848-0131 83.3 µM 0.303800864426317 0.354288806739354 no 1187 0.380639804065792 1928 6769040
SGTC_63 0099-0242 26.702 µM 0.302653094681064 0.354693808397618 no 1188 0.381077123589221 1906 3898502 YLR359W ADE13
SGTC_1848 st056003 16.4 µM 0.301534700814761 0.355088602555561 no 1189 0.381503396571716 1954 146492
SGTC_2049 5262831 67.185 µM 0.300726853449014 0.355373870316248 no 1190 0.381811395008166 1767 763417
SGTC_2745 rifampicin 24.3 µM 0.299911760138468 0.355661778920359 no 1191 0.382122231864472 1912 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2152 5568786 200 µM 0.29947911587701 0.35581463171294 no 1192 0.382287252182383 1799 5399883
SGTC_338 4055-0136 114 µM 0.29774909891408 0.356426076490143 no 1193 0.382947333247391 1740 2900563
SGTC_1261 0712-0010 12.7 µM 0.297320616680143 0.356577573287966 no 1194 0.38311087155172 1900 2840123
SGTC_300 r073-0011 5.04 µM 0.297253972408737 0.356601138478218 no 1195 0.383136309464528 1860 2735780
SGTC_2773 thioridazine 9.09 µM 0.296888615329527 0.356730337237013 no 1196 0.383275774085985 1839 5452 An antipsychotic.
SGTC_55 0767-0285 6.563 µM 0.296802434775085 0.356760815081568 no 1197 0.383308673254993 1906 3116166
SGTC_2370 9071495 200 µM 0.293323891836826 0.357991766922462 no 1198 0.384637296672173 1757 21791103
SGTC_1335 1486-0900 202 µM 0.293061523129301 0.35808467142315 no 1199 0.3847375631357 1786 X1335
SGTC_1898 st060199 18.6 µM 0.292983180362484 0.358112414149333 no 1200 0.384767503994509 1759 688866
SGTC_1675 st018485 24.5 µM 0.290412148436403 0.359023282468948 no 1201 0.385750475444581 1777 3323024
SGTC_1390 3413-2614 145 µM 0.289590800984296 0.359314439741325 no 1202 0.386064652670137 1782 3421432
SGTC_3336 9143619 71.43 µM 0.289216455741619 0.359447167508633 no 1203 0.386207869920652 1906 45595730
SGTC_166 k072-0058 166.424 µM 0.288260718950148 0.359786110227449 no 1204 0.386573586623743 1918 5846229
SGTC_2576 guaiol 23.12 µM 0.28772690020538 0.359975471859276 no 1205 0.386777898491665 1952 227829
SGTC_223 busulfan 5 mM 0.285479526482273 0.360773059640198 no 1206 0.387638393790173 1874 2478 A DNA alkylator.
SGTC_2521 angolensin 13.4 µM 0.285076163707901 0.360916276401439 no 1207 0.387792895641302 1830 821428 A flavenoid.
SGTC_3281 9140613 49.47 µM 0.283727174028849 0.361395386161792 no 1208 0.388309734141946 1712 16013766
SGTC_1245 0418-0076 17.2 µM 0.282879431001622 0.361696583513241 no 1209 0.388634631273711 1826 6790114
SGTC_2935 9038016 29.96 µM 0.28252236977699 0.361823470608602 no 1210 0.388771498160883 1939 6463195
SGTC_452 diindolylmethane 8 µM 0.281720859988663 0.362108354517407 no 1211 0.389078779064231 1863 3071 Inhibits expression of several cancer promoting factors.
SGTC_1175 0741-0056 27.6 µM 0.281214084974261 0.362288519075096 no 1212 0.389273101075403 1903 765927
SGTC_1526 st051518 75 µM 0.279835478929681 0.362778784236727 no 1213 0.389801865215346 1784 673993
SGTC_556 4058-0063 51.5 µM 0.279117180371337 0.363034317542307 no 1214 0.390077449424046 1820 6615692
SGTC_3164 9100705 49.47 µM 0.277507694998782 0.363607110091557 no 1215 0.390695149004343 1909 17174235
SGTC_2192 5915882 198.485 µM 0.277275029678857 0.36368993757452 no 1216 0.390784465795988 1833 2876149
SGTC_2834 9001755 58.44 µM 0.276955754686111 0.363803607959747 no 1217 0.390907040144223 1795 2989575
SGTC_1845 st056753 3.01 µM 0.276578461228119 0.363937949913691 no 1218 0.391051902603147 1732 5375839
SGTC_329 k048-0121 21.3 µM 0.272374471183095 0.365435982307885 no 1219 0.392667049976983 1803 6832902
SGTC_449 xestospongin c 11.1929 µM 0.271840951133392 0.365626242057287 no 1220 0.392872158004546 1891 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2070 5230947 200 µM 0.27060350966869 0.366067655964138 no 1221 0.393347998093697 1940 2835538
SGTC_3227 9130768 49.47 µM 0.270575688709103 0.366077582157445 no 1222 0.393358698072707 1884 17720899
SGTC_1499 4480-0877 67.3 µM 0.270152750817266 0.366228492490102 no 1223 0.393521370477947 1900 2861909
SGTC_1325 1431-0015 227 µM 0.269004947668532 0.36663814940704 no 1224 0.393962937638214 1768 1103340
SGTC_3224 9130643 49.47 µM 0.267850331782534 0.36705039115444 no 1225 0.394407263278544 1879 17644395
SGTC_2205 7238770 200 µM 0.264728277666371 0.368165849787988 no 1226 0.395609396001332 1949 279867
SGTC_2970 9090938 41.86 µM 0.263959864401856 0.368440562162426 no 1227 0.395905422876067 1989 17217104
SGTC_3112 9123419 49.47 µM 0.263840549126708 0.368483224129 no 1228 0.395951393802719 1870 17015854
SGTC_810 3825-7150 143 µM 0.262475348541764 0.368971475920177 no 1229 0.396477494159553 2005 22330411 YGL099W LSG1
SGTC_427 1354-0053 47.3 µM 0.260687351298756 0.369611256983938 no 1230 0.397166810541162 1934 6813657
SGTC_2606 farnesol 9.78 µM 0.260621673195875 0.369634764806372 no 1231 0.397192137177452 1942 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1973 st070275 50.2 µM 0.260405895436529 0.369712000449565 no 1232 0.397275347943176 1958 17118334
SGTC_2546 rhodinyl acetate 100 µM 0.259869485079756 0.369904026321701 no 1233 0.397482225086348 1974 6708682
SGTC_3176 9106582 49.47 µM 0.259141525936478 0.370164675312636 no 1234 0.397763022880702 1961 17018027
SGTC_906 1165-0455 526 µM 0.258533366404787 0.370382475251613 no 1235 0.397997650644822 1805 3252859
SGTC_2282 7944268 200 µM 0.257849312761079 0.370627504779653 no 1236 0.398261602417102 1911 2970414
SGTC_2029 5175081 200 µM 0.256895422640973 0.370969277939172 no 1237 0.398629752117605 1854 1380876
SGTC_1780 st038448 24.544 µM 0.25639616467711 0.371148199705953 no 1238 0.398822474524867 1931 728868 YDL195W SEC31
SGTC_735 3076-0345 636 µM 0.254820693818529 0.371712992161567 no 1239 0.399430795705429 1941 2888990
SGTC_248 streptozotocin 5.23457 mM 0.254663820854404 0.371769244882287 no 1240 0.399491380926651 1985 5300 DNA alkylating agent.
SGTC_901 1112-0062 60.1 µM 0.253071464210442 0.372340399195913 no 1241 0.40010649475775 1856 1908457
SGTC_578 3460-0051 92 µM 0.252826770939899 0.372428191913153 no 1242 0.400201039700456 1984 2876744
SGTC_2002 4023503 131 µM 0.252242171179629 0.372637965426784 no 1243 0.400426941878833 2051 4736863 YCR052W RSC6
SGTC_1399 3562-5772 25 µM 0.251369745240832 0.372951090636321 no 1244 0.400764128342967 1866 23847490
SGTC_2341 7987486 176.74 µM 0.250295937997515 0.373336609501776 no 1245 0.401179248763468 2009 1258686
SGTC_2199 6590217 200 µM 0.248684286523527 0.37391546341557 no 1246 0.401802502301875 1938 703109
SGTC_2444 5485484 36.41 µM 0.248423566180148 0.374009132630488 no 1247 0.401903350892421 1934 6790631
SGTC_718 1130-0073 349 µM 0.247960295682187 0.374175590560289 no 1248 0.402082563518029 1920 6740020
SGTC_1055 3448-0672 86 µM 0.246725504805053 0.374619378351193 no 1249 0.402560333332333 1891 748378
SGTC_2852 9023854 51.95 µM 0.245941876588323 0.374901103044086 no 1250 0.402863613187513 1918 19798528
SGTC_599 1935-0052 86.5 µM 0.240988864041724 0.376683315473086 no 1251 0.404781873712198 1891 9557311
SGTC_535 2293-4129 48.2 µM 0.239890139458252 0.377079020811768 no 1252 0.405207712634845 1996 396118 YIL048W NEO1
SGTC_3127 9126946 49.47 µM 0.239413526094518 0.377250713156586 no 1253 0.405392471318589 1798 27243249
SGTC_558 k064-0027 21.3 µM 0.239353402222468 0.377272373544717 no 1254 0.405415779774593 1925 5088526
SGTC_1166 k206-0078 225 µM 0.238807629787251 0.377469012645386 no 1255 0.405627376835932 1840 5404595
SGTC_1409 3909-8004 61.9 µM 0.238649420109066 0.377526020748978 no 1256 0.405688720202558 1891 2119279
SGTC_3088 9117578 49.47 µM 0.237592156433462 0.377907055753656 no 1257 0.406098717299604 2017 678341
SGTC_487 nimodipine 119 µM 0.236148537010711 0.378427524154318 no 1258 0.406658705846371 2002 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1765 st044815 90.4 µM 0.235403048159139 0.378696381847041 no 1259 0.406947960227519 1802 645695
SGTC_793 0488-0545 106 µM 0.233897900146426 0.379239386531806 no 1260 0.407532121721128 1846 292548
SGTC_1456 k015-0012 13 µM 0.233637960141138 0.379333187946272 no 1261 0.407633027641073 2051 2989616
SGTC_3041 9091929 49.47 µM 0.232787555209378 0.379640112927478 no 1262 0.40796318849422 1947 25236887
SGTC_823 0417-1665 178 µM 0.23277048457402 0.379646274774838 no 1263 0.407969816660505 1909 3429856
SGTC_1036 k216-0215 33.5 µM 0.230220856841715 0.380566935374885 no 1264 0.408960077841814 1838 622330
SGTC_654 1124-0271 80.9 µM 0.229854300631496 0.380699353158805 no 1265 0.409102494175828 1826 5403748
SGTC_1778 st046819 58.9 µM 0.229813105854523 0.380714235573198 no 1266 0.409118500136214 1861 671715
SGTC_1588 farnesol 29.9 µM 0.229763855442953 0.380732028473922 no 1267 0.409137636259457 1868 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2418 pentamidine 31.67 µM 0.228122210547466 0.381325256466209 no 1268 0.409775616879917 2022 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2561 acetosyringone 100 µM 0.224569701764518 0.382609951235027 no 1269 0.411157018672419 2046 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1116 jasmonic acid 1.58368 µM 0.224505263501411 0.382633266043063 no 1270 0.411182085880233 1970 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3086 9117350 49.47 µM 0.224326798659411 0.382697839735718 no 1271 0.411251512600125 1937 2679265
SGTC_2159 5658611 73.75 µM 0.222991457654265 0.383181107739589 no 1272 0.411771077466686 2004 793844
SGTC_2886 9058944 51.95 µM 0.22279002344979 0.38325402380307 no 1273 0.411849466506829 1939 4949929
SGTC_369 0957-0393 4.5 µM 0.221732604039646 0.38363686104651 no 1274 0.412261023732644 1839 6997992
SGTC_1717 st033143 58.0435 µM 0.220748678114984 0.383993192135335 no 1275 0.412644063315067 2013 674616
SGTC_3226 9131256 49.47 µM 0.219054389497347 0.384607012480285 no 1276 0.413303839885325 1954 17178073
SGTC_976 1348-1067 47.6 µM 0.218654688510645 0.384751861576951 no 1277 0.413459524076555 1923 5310671 YGL099W LSG1
SGTC_723 4182-0001 115 µM 0.218455909628258 0.384823903771615 no 1278 0.413536953845552 1882 744821 YLR208W SEC13
SGTC_3148 9097893 49.47 µM 0.217760798512291 0.385075859825029 no 1279 0.41380774490697 1821 17174100
SGTC_2475 5812728 15.03 µM 0.214220763207224 0.386359762766173 no 1280 0.415187452600659 2013 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_587 k089-0003 57 µM 0.213506428545325 0.386618989692782 no 1281 0.415465987731469 2045 9659696
SGTC_311 1315-0136 58 µM 0.213333626654024 0.386681705865278 no 1282 0.41553337345732 2007 6759207
SGTC_1234 0326-0494 15.5 µM 0.211174068244853 0.387465738287429 no 1283 0.416375722503862 2018 1547813
SGTC_2175 5807670 165.306 µM 0.209981154394312 0.387899025370866 no 1284 0.416841190876658 2039 241186
SGTC_1238 0333-0287 48.8 µM 0.207726388052073 0.388718376697614 no 1285 0.417721306196588 1929 7226
SGTC_19 0279-0214 38.434 µM 0.20745646253218 0.388816497215911 no 1286 0.417826695424895 1971 3566274 YBR002C RER2
SGTC_3328 9140624 29.0385 µM 0.205973449859897 0.389355712943129 no 1287 0.418405825281407 2036 4904392
SGTC_1518 st038567 90.8 µM 0.205935514594123 0.389369508809084 no 1288 0.418420641671654 2045 77966
SGTC_102 gallobenzophenone 83.616 µM 0.20575117881428 0.389436547933427 no 1289 0.418492639410148 2035 70837
SGTC_2570 licareol 100 µM 0.204945555583599 0.389729575091212 no 1290 0.418807331177185 1901 443158
SGTC_1429 4049-0205 9.46 µM 0.204206505757179 0.389998442824888 no 1291 0.419096063809332 2030 22774478
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.203999798861439 0.390073652612429 no 1292 0.419176828045344 2056 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1403 3909-7815 62.9 µM 0.203593711552398 0.390221418445999 no 1293 0.41933550383867 1943 6615483
SGTC_2718 lomofungin 53.02 µM 0.202012031721793 0.390797106386544 no 1294 0.419953659070212 2032 5351222 A RNA synthesis inhibitor.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.201593318780135 0.390949546508956 no 1295 0.420117334418395 2028 5282309
SGTC_595 3909-8003 73.7 µM 0.2010952836823 0.39113088713508 no 1296 0.420312034872593 1995 699517
SGTC_1449 4112-4002 201 µM 0.199638697901479 0.391661383418003 no 1297 0.420881580208531 1880 2059539
SGTC_2557 derrustone 83.84 µM 0.199189301536937 0.391825096688329 no 1298 0.421057333939131 1872 629853 An antioxidant.
SGTC_642 0335-0876 158 µM 0.198810384023445 0.391963149686478 no 1299 0.421205536431634 1950 6812350
SGTC_3080 9117754 49.47 µM 0.197750148798053 0.392349502955097 no 1300 0.421620275662351 2058 9550191
SGTC_120 rhodamine 6G 52.259 µM 0.197015948330753 0.392617110285059 no 1301 0.421907528707817 2078 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_697 0508-1955 564 µM 0.196893483931552 0.392661752045078 no 1302 0.421955446470065 2075 6243113
SGTC_2975 9084847 53.72 µM 0.195479708583691 0.393177215519968 no 1303 0.422508710729882 1903 27211724
SGTC_316 k060-0003 58.6 µM 0.194689480032226 0.393465415078066 no 1304 0.42281802402137 2033 6152314
SGTC_2274 7947094 46.08 µM 0.194176131060964 0.393652666821007 no 1305 0.423018985907346 2113 2971028
SGTC_1742 st038235 28.8875 µM 0.193679312054199 0.393833912432584 no 1306 0.423213495846845 1950 564103 YBR002C RER2
SGTC_682 0kpi-0099 17 µM 0.192596874959119 0.394228878234915 no 1307 0.423637346265002 1930 1714895 YML126C ERG13
SGTC_1319 1306-0155 43.7 µM 0.192562971022413 0.394241251055324 no 1308 0.423650623475751 1989 3122360
SGTC_2221 6807166 181.081 µM 0.190232726332914 0.395091899995778 no 1309 0.424563383715089 2035 674925
SGTC_814 3342-0569 96 µM 0.189766923292967 0.39526200014037 no 1310 0.424745888132019 2021 4346283
SGTC_3048 9093155 49.47 µM 0.189660149221648 0.395300994294056 no 1311 0.42478772512604 2086 25236002
SGTC_861 0443-0273 110 µM 0.189586604045402 0.395327853783242 no 1312 0.424816542625257 2010 6149169
SGTC_912 3474-0017 2.18 µM 0.189296758657812 0.395433713275969 no 1313 0.424930117808229 2033 3360550
SGTC_2924 9010168 62.78 µM 0.189067813643794 0.395517335735288 no 1314 0.425019833739304 1959 2993929
SGTC_1082 camptothecin 424.86 nM 0.188371044993726 0.395771860959534 no 1315 0.425292898058537 1755 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3114 9122766 49.47 µM 0.185596370725157 0.396785872053912 no 1316 0.42638064993025 1928 17176985
SGTC_2283 7944793 200 µM 0.183802498951923 0.397441818755504 no 1317 0.427084197829565 1935 2970533
SGTC_1075 aripiprazole 15.2 µM 0.183160845769348 0.397676516043011 no 1318 0.427335907578018 1956 60795 An atypical antipschotic. YIL048W NEO1
SGTC_548 1436-0017 110 µM 0.182802022089858 0.397807779024488 no 1319 0.427476680974916 2089 9677137
SGTC_2155 5570423 76 µM 0.182532239951439 0.397906476920365 no 1320 0.427582527753361 1950 797402
SGTC_818 4072-2707 53.5 µM 0.18246119392706 0.397932469695359 no 1321 0.427610402937579 2005 882871
SGTC_2080 5212524 12.4 µM 0.1820972673648 0.3980656223365 no 1322 0.427753196604231 2131 260183
SGTC_1327 1436-0082 2.18 µM 0.180772150449617 0.398550553374317 no 1323 0.428273211830089 1970 15992205
SGTC_1243 0416-0003 5.65 µM 0.18077085892358 0.398551026089209 no 1324 0.428273718724171 1952 2141977
SGTC_2073 5212005 126 µM 0.17994859117507 0.39885201668879 no 1325 0.428596463774753 2133 691789
SGTC_1063 disulfiram 1.84 µM 0.175898208328063 0.400335531634056 no 1326 0.430186956476518 2063 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2861 9024595 19.48 µM 0.175435470676739 0.400505108405285 no 1327 0.430368735593049 2117 16482810
SGTC_2682 pyrogallin 40.03 µM 0.175365793026797 0.400530644393195 no 1328 0.430396108627408 2069 822798 An ATP competetive kinase inhibitor.
SGTC_3118 9124250 49.47 µM 0.173521271146529 0.401206792884228 no 1329 0.431120854763057 1981 1504786
SGTC_2126 5251174 33.877 µM 0.173416486419262 0.401245212844891 no 1330 0.43116203357165 2109 790722
SGTC_2302 7771753 200 µM 0.171750989564147 0.401856005417447 no 1331 0.431816648751124 1940 2203047
SGTC_2839 9003951 25.97 µM 0.171502795156725 0.401947047050272 no 1332 0.431914216393867 2185 2990634
SGTC_1971 st069429 63.5 µM 0.171146931877052 0.402077592610419 no 1333 0.432054116965611 2112 1246522 YGL099W LSG1
SGTC_2026 5148700 152 µM 0.170593420743897 0.402280665389726 no 1334 0.432271735788149 1992 79838
SGTC_2531 methyl deoxycholate 70.07 µM 0.168749049005802 0.40295752062785 no 1335 0.43299701822154 1979 16667744 Haematoxylin.
SGTC_1173 0443-0020 122 µM 0.16836645326723 0.403097963707275 no 1336 0.433147498874175 1967 5331295
SGTC_604 1000-0114 314 µM 0.167934012298373 0.403256719002169 no 1337 0.433317596074062 2095 1572745
SGTC_2821 7996764 71.43 µM 0.167633766302872 0.403366953003046 no 1338 0.43343570270519 2017 2987135
SGTC_1877 wortmannin 25 µM 0.167605971491965 0.403377158134455 no 1339 0.433446636545569 2115 312145 A covalent inhibitor of PI 3-kinase.
SGTC_615 k087-0205 167 µM 0.164182507947572 0.404634616677091 no 1340 0.434793735440509 1993 9642773
SGTC_2470 5664817 21.68 µM 0.163404460555086 0.404920536032825 no 1341 0.435099995536441 2153 2859561
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.16292091663151 0.405098255896352 no 1342 0.435290350885125 2084 616764
SGTC_1820 st053765 18.6 µM 0.16152368675849 0.405611898227362 no 1343 0.435840478480739 1977 3690829
SGTC_1981 st071826 47 µM 0.160742702476647 0.405899070467721 no 1344 0.436148027508003 2014 11838600
SGTC_1475 4092-1048 11.7 µM 0.159731131270454 0.406271106055543 no 1345 0.436546438271139 2036 2881759
SGTC_1583 clindamycin 39.6 µM 0.15846505295128 0.406736863478566 no 1346 0.437045178194652 1940 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_685 1278-0033 54.9 µM 0.155831653551225 0.407706044859495 no 1347 0.438082859740365 2104 3590572
SGTC_100 0086-0128 49.5915 µM 0.155423409680828 0.407856343361977 no 1348 0.438243765075757 1922 93297
SGTC_1061 3448-9325 110 µM 0.153469000691016 0.408576063385826 no 1349 0.439014217276377 2164 723482
SGTC_1351 1496-0003 46.5 µM 0.153236313825329 0.408661771980344 no 1350 0.439105960770112 2128 3891978
SGTC_2403 6032726 181.2 µM 0.152664944759353 0.408872250342134 no 1351 0.43933125333751 2030 2881040
SGTC_943 3253-1379 105 µM 0.150295308510778 0.40974544613748 no 1352 0.440265817107775 2095 668464
SGTC_2776 terbinafine 19.92 µM 0.150152697749729 0.409798011620509 no 1353 0.440322072213686 2146 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1369 1866-0067 208 µM 0.14815809295348 0.410533380650834 no 1354 0.441109001861311 2122 3531355
SGTC_2319 6033012 152.6 µM 0.148126785575423 0.410544925540401 no 1355 0.441121355395188 2030 847246
SGTC_207 4185-0010 4.486 µM 0.146959702186071 0.410975353714979 no 1356 0.441581913945535 2138 3761753
SGTC_2994 9053520 71.4286 µM 0.146346423042597 0.411201578176084 no 1357 0.441823960019441 2122 4647384
SGTC_1726 st035556 14.5795 µM 0.144145939854821 0.412013527986739 no 1358 0.442692614368246 2132 5919439
SGTC_2238 6671620 73.2395 µM 0.143805440077371 0.412139201749083 no 1359 0.442827053485186 2189 729941
SGTC_2726 cimetidine 79.27 µM 0.14303956286372 0.412421909353086 no 1360 0.443129467895792 2173 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2427 5545055 42.75 µM 0.142324267048257 0.412685986933928 no 1361 0.44341193965171 2070 5372858
SGTC_2899 9053889 58.44 µM 0.14221621233155 0.412725882719197 no 1362 0.44345461318039 2192 6470052
SGTC_802 4112-3352 742 µM 0.141897605245064 0.412843523551909 no 1363 0.443580442957695 2126 704594
SGTC_2620 irigenin 100 µM 0.141555949697164 0.41296968337706 no 1364 0.443715381749548 2104 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_699 0375-0592 111 µM 0.141345812653678 0.413047283107164 no 1365 0.443798379806309 2208 762578
SGTC_1489 4065-0444 182 µM 0.14089337993436 0.413214369685045 no 1366 0.443977086012943 2163 2877968
SGTC_3074 9116018 49.47 µM 0.140838848311059 0.413234509658322 no 1367 0.44399862620554 2069 17027303
SGTC_811 0416-0114 265 µM 0.139875635095692 0.413590287406454 no 1368 0.444379126193623 2027 6612453
SGTC_1885 st057546 99.9 µM 0.139808036944456 0.413615258500378 no 1369 0.444405831551936 2149 702008
SGTC_1937 st074714 47.2 µM 0.138997528926647 0.413914691380418 no 1370 0.444726050862179 2081 17250970
SGTC_105 0111-0055 734.78 µM 0.137645998942217 0.414414109859162 no 1371 0.445260099805255 2098 5179370
SGTC_1916 st067606 49.2 µM 0.137590958751844 0.414434451294195 no 1372 0.445281850717441 2127 19590279
SGTC_262 fenpropimorph 62.5 µM 0.137174640335081 0.414588319274398 no 1373 0.445446377741267 2148 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3058 9093861 49.47 µM 0.136366818871161 0.414886921041529 no 1374 0.445765651654809 2125 17217477
SGTC_1231 0242-0792 125 µM 0.136319431853188 0.414904438627901 no 1375 0.445784381440072 2042 3707635
SGTC_798 1287-0182 476 µM 0.135684140625764 0.415139303430097 no 1376 0.446035492855543 2169 1649755
SGTC_2124 5246320 200 µM 0.134737086779885 0.415489481995279 no 1377 0.446409874765524 2080 579342
SGTC_2486 5283202 22.39 µM 0.134332360504783 0.415639152336228 no 1378 0.446569882577489 2019 1377751
SGTC_1574 spiramycin 23.7 µM 0.134223435928596 0.415679435425812 no 1379 0.446612947201456 2151 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1016 4226-1401 38 µM 0.132036796905227 0.41648829726386 no 1380 0.447477593403765 2177 2901613
SGTC_2048 5246248 200 µM 0.131983043671997 0.416508185645282 no 1381 0.447498851800876 2186 677046
SGTC_160 3453-0671 289.699 µM 0.131540791948569 0.41667182430125 no 1382 0.447673759794908 2119 5322268
SGTC_1208 2323-2347 50.3 µM 0.13152509480053 0.416677632707427 no 1383 0.447679968113192 2203 5412760
SGTC_1421 4029-0249 71.4 µM 0.131288784086188 0.416765076815477 no 1384 0.447773431997531 2197 2894095
SGTC_1851 st056236 18.9 µM 0.131272289187855 0.416771180719933 no 1385 0.447779956047332 2190 5393171
SGTC_2744 captopril 92.04 µM 0.130482150407102 0.417063593486267 no 1386 0.448092487658491 2179 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1030 k029-0042 36.7 µM 0.130096875779283 0.417206191697367 no 1387 0.448244890940896 2041 6080581
SGTC_2785 7756463 72.73 µM 0.129882286749598 0.417285620316466 no 1388 0.448329779347322 2101 2201551
SGTC_303 1348-1668 34.2 µM 0.129245265252748 0.417521429212051 no 1389 0.448581790026969 2091 5380509
SGTC_3205 9113483 49.47 µM 0.129144198958875 0.417558844070887 no 1390 0.448621774551938 2151 17018033
SGTC_178 4092-0806 87.505 µM 0.127371968206499 0.418215046943769 no 1391 0.449323000820189 2186 2169044
SGTC_42 0133-0086 60.653 µM 0.126993867127534 0.418355075750654 no 1392 0.44947262628617 2155 162923 Model of phenazepam hydroxylation.
SGTC_593 1203-0218 61.7 µM 0.125964067164484 0.418736512064149 no 1393 0.449880184105475 2187 3666956
SGTC_2387 9077560 195.08 µM 0.125883289270628 0.418766435307731 no 1394 0.449912155334883 2029 5303272
SGTC_1094 duloxetine 25.4 µM 0.125734122079293 0.418821693816783 no 1395 0.449971195342956 2082 60834 A selective serotonin reuptake inhibitor.
SGTC_1534 6-azauridine 81.6 µM 0.123663647229738 0.419588859541945 no 1396 0.450790797985797 2171 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_401 neomycin 50 µM 0.123147236340293 0.419780251192924 no 1397 0.450995253363616 2090 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_712 r015-0009 80.6 µM 0.121399570024317 0.420428109931474 no 1398 0.451687278716536 2150 6813872 YLR060W FRS1
SGTC_1207 2099-0101 141 µM 0.119778035676182 0.421029404519108 no 1399 0.452329490825942 2183 5837381
SGTC_1879 gemcitabine 100 µM 0.1195521752549 0.421113172344865 no 1400 0.45241895325942 2163 60750 A nucleoside analog which inhibits DNA replication.
SGTC_17 0960-0276 49.807 µM 0.119370905431199 0.421180404852528 no 1401 0.452490755278427 2198 6821114
SGTC_220 paclitaxel 373.376 µM 0.119055203504323 0.421297503364917 no 1402 0.452615810334082 2185 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_276 colchicine 750 µM 0.119043316033291 0.421301912739745 no 1403 0.452620519261203 2095 2833 A microtubule depolymerizer.
SGTC_1656 st012921 11 µM 0.117583516748221 0.421843465445789 no 1404 0.453198833031329 2171 6732821
SGTC_2202 7226349 200 µM 0.116711465154001 0.422167047577714 no 1405 0.453544352246798 2182 844334
SGTC_1920 st075728 45.7 µM 0.114822554412946 0.42286812380272 no 1406 0.454292885728261 2210 3400306
SGTC_2229 7354935 190 µM 0.11477972525551 0.422884022844719 no 1407 0.454309859866998 2194 318112
SGTC_985 1493-0307 8.71 µM 0.113891345037882 0.423213835680826 no 1408 0.454661963291271 2201 3278274
SGTC_373 0844-0104 25.9 µM 0.112974654791732 0.423554215083283 no 1409 0.455025324547 2227 5375804
SGTC_330 1488-0319 80.1 µM 0.112415089891633 0.423762017106343 no 1410 0.455247145581181 2098 6846614
SGTC_1685 st024049 53.0905 µM 0.11167692559654 0.42403617686435 no 1411 0.455539787784098 2128 1941139
SGTC_596 1155-0152 116 µM 0.111435875250013 0.42412571274189 no 1412 0.455635356436983 2172 280313
SGTC_328 k915-0120 63.5 µM 0.109539083301829 0.42483039451668 no 1413 0.456387462132763 2205 6624543
SGTC_900 1112-0045 141 µM 0.109068724545396 0.425005175906285 no 1414 0.456573990531785 2204 56211 YIL048W NEO1
SGTC_2673 kobusone 100 µM 0.108418635635902 0.425246767783763 no 1415 0.456831809584498 2217 6710676 An epoxy ketone and protein crosslinker.
SGTC_320 4092-0846 5.34 µM 0.106781581049421 0.425855268870814 no 1416 0.457481130055629 2197 1359356
SGTC_1602 st001878 87.6 µM 0.103999242366814 0.426889881993644 no 1417 0.4585849749074 2172 595405 YLR310C CDC25
SGTC_785 1270-0111 65.3 µM 0.103510053678921 0.427071839105122 no 1418 0.45877908533728 2257 6741994
SGTC_1443 4112-3303 14 µM 0.103236617532544 0.427173552331959 no 1419 0.45888758928606 2186 704433
SGTC_65 0798-0905 34.986 µM 0.101958028347629 0.427649228181142 no 1420 0.459394994967274 2217 3602145
SGTC_3085 9117376 49.47 µM 0.101677952391288 0.427753439414056 no 1421 0.45950615143757 2130 16480349
SGTC_1610 st001799 48.1 µM 0.100785996477894 0.428085353739388 no 1422 0.45986017171224 2060 621897
SGTC_383 2324-0395 7.37 µM 0.100006397128981 0.428375499663901 no 1423 0.460169623367138 2178 3146421
SGTC_1732 st034308 51.822 µM 0.0993126578468707 0.428633723344156 no 1424 0.460445014297172 2012 830119
SGTC_3182 9108849 49.47 µM 0.0981411084092845 0.429069866863165 no 1425 0.460910122637657 2152 17133045
SGTC_2630 antimycin a 100 µM 0.0973086112085052 0.429379840951077 no 1426 0.461240658850613 2217 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_192 3455-0609 60.9 µM 0.0952418798615239 0.430149560723938 no 1427 0.462061352919588 2183 3769639
SGTC_1339 1486-1321 22.7 µM 0.0950875563990725 0.430207046624699 no 1428 0.462122640922283 2114 3469382
SGTC_3244 9134489 49.47 µM 0.0926447386540329 0.431117199000134 no 1429 0.46309290012885 2127 16584271
SGTC_251 melphalan 456.522 µM 0.0923924052443381 0.431211235073092 no 1430 0.463193136678437 2176 460612 A DNA alkylator.
SGTC_804 1595-0054 20.9 µM 0.0909537084259303 0.431747462747532 no 1431 0.463764686926338 2099 761523 Stimulates phospholipase C.
SGTC_2477 5967686 25.23 µM 0.0907372850159625 0.431828138477356 no 1432 0.463850671829223 2196 776118
SGTC_2136 5328288 199.296 µM 0.0903769449895203 0.431962468028255 no 1433 0.463993838469648 2171 262395
SGTC_831 k061-1017 217 µM 0.090025034864985 0.432093662626614 no 1434 0.464133660327347 2215 1240153
SGTC_1969 st069479 40.1 µM 0.0889462883654848 0.432495873599566 no 1435 0.464562298256385 2235 3895485
SGTC_389 tpck 16.7 µM 0.0888363589273602 0.432536864760119 no 1436 0.464605980833123 2156 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2934 9036370 36.88 µM 0.0885953865029771 0.432626722569756 no 1437 0.464701737352828 2219 6462800
SGTC_1433 4060-0023 7.6 µM 0.088148770751784 0.432793273297036 no 1438 0.464879216878568 2215 3840627
SGTC_710 3448-4187 58 µM 0.0873487737582847 0.433091635822835 no 1439 0.465197143144054 2235 3946412
SGTC_132 0417-1715 25.805 µM 0.0866478623311111 0.433353075290242 no 1440 0.465475710148181 2266 6769098
SGTC_2446 5162541 200 µM 0.0865900183345314 0.433374652364543 no 1441 0.465498700156919 2210 1549321
SGTC_127 0180-0333 59.125 µM 0.0865763953077876 0.433379734080003 no 1442 0.465504114625 2261 771601
SGTC_2388 9080168 200 µM 0.0840323583075708 0.434328913038154 no 1443 0.466515352268436 2245 15943073
SGTC_624 k048-0052 28 µM 0.0826299696765633 0.434852305825012 no 1444 0.467072885199484 2169 6835531
SGTC_2867 9039098 71.43 µM 0.0824620074866243 0.434914999546035 no 1445 0.467139664518678 2277 6463460
SGTC_1811 st050069 61.5 µM 0.0823390244733002 0.434960905336196 no 1446 0.467188561359349 2276 3877702
SGTC_1097 itavastatin 7.23 µM 0.0806637367496518 0.435586325964704 no 1447 0.467854688342614 2271 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1733 st037357 54.9 µM 0.0802213395947381 0.435751509214722 no 1448 0.468030609157237 2271 1272339 YGL099W LSG1
SGTC_2450 5739737 12.93 µM 0.0799862277519571 0.43583930036953 no 1449 0.468124104767308 2179 2262825
SGTC_1664 st014217 9.02 µM 0.0795149711269796 0.43601527789594 no 1450 0.46831151203964 2271 3982782
SGTC_1713 st033146 12.748 µM 0.077425009321877 0.436795867521405 no 1451 0.46914272296681 2265 674619
SGTC_2677 mitomycin C 100 µM 0.0767656363706827 0.43704219103953 no 1452 0.469404994122472 2262 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1731 st035964 63 µM 0.0758631124659162 0.437379388588155 no 1453 0.469764002121019 2068 6739575
SGTC_992 3909-8734 162 µM 0.0747129871826301 0.437809159911637 no 1454 0.470221537139164 2217 4288319
SGTC_739 1486-1183 203 µM 0.0743348870059295 0.437950461972757 no 1455 0.470371958996728 2288 4346692
SGTC_1827 berberine 7.24 µM 0.0734954694023359 0.438264193963548 no 1456 0.47070592460991 2210 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_839 0122-0028 230 µM 0.0730425641213804 0.438433483258374 no 1457 0.470886123339418 2194 759448
SGTC_857 0438-0306 1.35 µM 0.0708675159855983 0.43924664050546 no 1458 0.471751598419313 2191 4686136
SGTC_1224 0823-0416 294 µM 0.0704990333723479 0.439384425852375 no 1459 0.471898234947358 2262 3598164
SGTC_2459 5811157 9.22 µM 0.0700347356953291 0.439558049427872 no 1460 0.472083006208193 2289 2870684 YBR192W RIM2
SGTC_1637 st007924 17.4 µM 0.0696638751158342 0.43969674066366 no 1461 0.472230597689212 2278 683336
SGTC_2984 9022109 38.96 µM 0.0686638040659764 0.440070775437726 no 1462 0.47262861517294 2290 6459207
SGTC_6 0844-0013 19.835 µM 0.0682473157202235 0.440226561290702 no 1463 0.472794381123585 2285 1584900
SGTC_2289 7946404 165.07 µM 0.0680487605261649 0.440300833351014 no 1464 0.472873409462201 2247 1246120 YPR165W RHO1
SGTC_1963 st076565 50.3 µM 0.0673850385680475 0.44054912210515 no 1465 0.473137589804128 2280 4914280
SGTC_2635 hydroquinidine 100 µM 0.0671771935571836 0.440626878718727 no 1466 0.473220320503975 2257 442912 An experimental heart treatment.
SGTC_2796 7949634 45.45 µM 0.0667852355465353 0.440773519822724 no 1467 0.473376338746119 2252 2971588
SGTC_1972 st070201 17.4 µM 0.0664114821581345 0.440913357696203 no 1468 0.473525114472647 2284 2829099
SGTC_3342 9147791 14.508 µM 0.066356199135168 0.440934042175719 no 1469 0.473547120665831 2283 1838168
SGTC_3032 9089427 49.47 µM 0.0653713346422593 0.441302562173668 no 1470 0.473939173444315 2218 17173707
SGTC_3177 9107506 49.47 µM 0.0650820384211676 0.441410821704806 no 1471 0.4740543406866 2281 8897194
SGTC_1088 bifonazole 369 nM 0.0632230375303954 0.442106595332494 no 1472 0.4747944500889 2287 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3070 9117005 49.47 µM 0.0624421549610361 0.442398911908526 no 1473 0.475105362816178 2301 8779016
SGTC_1102 cgs 12066b 26.1 µM 0.0621654944596319 0.44250248488586 no 1474 0.475215520376569 2213 6438352 A 5-HT1B full agonist.
SGTC_1479 0549-0158 134 µM 0.0616631467013618 0.442690558104995 no 1475 0.475415544382737 2288 5440202
SGTC_1760 st045453 10.4495 µM 0.0615525203765082 0.442731977064537 no 1476 0.475459594225508 2293 3323419 YIL048W NEO1
SGTC_730 1436-0052 41.2 µM 0.0611813989800592 0.442870931039623 no 1477 0.475607371720818 2308 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1824 st053723 68.6 µM 0.0610410026819289 0.442923499563403 no 1478 0.475663277250777 2224 675225
SGTC_3253 9135987 49.47 µM 0.0608403650531093 0.442998625965684 no 1479 0.475743171591514 2279 4182430
SGTC_278 4092-0821 23.9 µM 0.0599730529995252 0.443323404314522 no 1480 0.476088548319255 2256 877900
SGTC_1434 4073-0095 163 µM 0.0594100568016765 0.443534247302262 no 1481 0.476312751520153 2295 24133745
SGTC_897 1000-0139 31.4 µM 0.0588122712320141 0.443758136463567 no 1482 0.4765508171753 2294 6151020
SGTC_1629 st005085 44.9 µM 0.0577779699734822 0.444145556597101 no 1483 0.476962743136349 2254 24207091
SGTC_2384 9036245 200 µM 0.0572110949147925 0.44435791470377 no 1484 0.477188520086846 2260 6462766
SGTC_530 4358-1714 28 µM 0.0556223621532622 0.444953157729234 no 1485 0.477821324829059 2228 1564641
SGTC_3206 9114350 49.47 µM 0.0555682252378437 0.444973443147294 no 1486 0.477842888982146 2311 17087243
SGTC_651 3253-0966 34.4 µM 0.0542744587126833 0.445458267764363 no 1487 0.478358249273211 2280 781462
SGTC_2964 9083345 53.42 µM 0.0542309013054643 0.445474591841876 no 1488 0.478375600610217 2258 17741579
SGTC_1747 st037496 66.6 µM 0.0537934699800616 0.445638533784019 no 1489 0.478549856094661 2289 723305
SGTC_1705 st027868 56.3335 µM 0.0537406722924795 0.445658322103227 no 1490 0.478570888900712 2304 292948
SGTC_1689 st020265 53.493 µM 0.0535136070162096 0.445743426618402 no 1491 0.478661344676542 2311 5758320 YPR016C TIF6
SGTC_414 piperonyl butoxide 100 µM 0.0520139017108285 0.446305581738415 no 1492 0.479258808222601 2288 5794 A potent inhibitor of cytochrome P450.
SGTC_2339 9000433 200 µM 0.0497655635801447 0.447148559036526 no 1493 0.480154604472974 2260 2988954
SGTC_2594 a-mangostin 100 µM 0.048638850432046 0.44757109161722 no 1494 0.480603554211299 2295 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2190 6049624 200 µM 0.047408261500566 0.448032646984723 no 1495 0.481093922350121 2296 2265554
SGTC_3320 9137005 35.139 µM 0.0472982542778185 0.448073910684115 no 1496 0.481137759705909 2174 4908713
SGTC_2736 butenafine 14.65 µM 0.0471311109904542 0.448136607191479 no 1497 0.481204365948464 2287 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_435 c-PAF 6.7 µM 0.0469839059141854 0.448191825822392 no 1498 0.481263027291149 2318 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2464 5717415 7.67 µM 0.0439396523759802 0.449333990310564 no 1499 0.482476253891576 2328 5285744
SGTC_905 2-aminofluorene 215 µM 0.0438588196102815 0.449364323482007 no 1500 0.482508470441537 2334 1539 An established DNA mutagen. YPR165W RHO1
SGTC_39 0986-0283 58.349 µM 0.0438356048791897 0.44937303505873 no 1501 0.482517722880753 2314 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3332 9141069 11.198 µM 0.0424375315370052 0.44989772190578 no 1502 0.483074954723124 2325 17332883
SGTC_286 k060-0067 22.9 µM 0.041797500893915 0.450137950077645 no 1503 0.483330063635723 2314 5985051
SGTC_2499 avocadenofuran 51.48 µM 0.0408100607940065 0.450508610219525 no 1504 0.483723659344136 2336 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_12 0849-0099 9.267 µM 0.0406744253301744 0.450559527735706 no 1505 0.483777725173956 2344 6071388
SGTC_423 5-fluorouracil 457 µM 0.0403971432196729 0.45066362189567 no 1506 0.483888253886152 2337 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2518 prenyletin 46.28 µM 0.0399730381680791 0.450822841250397 no 1507 0.484057310766143 2332 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2706 st078239 82.5 µM 0.039514218093464 0.450995102380421 no 1508 0.484240208985357 2344 15434492
SGTC_1624 st003710 6.25 µM 0.0391436302169083 0.451134244022834 no 1509 0.484387937862009 2322 24207033
SGTC_2643 anethole 100 µM 0.0373253837418504 0.451817013052383 no 1510 0.485112783146131 2326 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_201 4262-0159 12.803 µM 0.0346753313044461 0.452812387949905 no 1511 0.486169315931014 2340 1341029
SGTC_2868 9035608 32.47 µM 0.0345902521949506 0.452844349098697 no 1512 0.48620323723574 2339 6462614
SGTC_298 1391-0729 10 µM 0.0338080605212364 0.453138204551151 no 1513 0.486515104127482 2327 3237558
SGTC_1613 st002381 52.1 µM 0.0329397129736737 0.45346445728034 no 1514 0.486861331796702 2358 551167
SGTC_469 w7 172 µM 0.0322490796378656 0.45372396223741 no 1515 0.487136708311012 2343 45115570 A P450 inhibitor.
SGTC_2997 9067075 71.4286 µM 0.0303283081163147 0.454445794246464 no 1516 0.487902610170293 2315 27209819
SGTC_1506 4226-2149 212 µM 0.0301084975606732 0.454528409387908 no 1517 0.487990261865648 2272 991114
SGTC_1056 3448-1962 115 µM 0.0297250455697744 0.454672533381273 no 1518 0.488143168634283 2318 715507
SGTC_1806 st050005 60.3 µM 0.0289310590633737 0.454970979535889 no 1519 0.488459787216849 2318 5194765
SGTC_836 0330-0104 1.35 µM 0.028888485706172 0.454986982863284 no 1520 0.488476764433006 2360 46494820
SGTC_561 1550-0330 72.9 µM 0.0275583971018745 0.45548699990881 no 1521 0.4890071816775 2335 6812934
SGTC_402 epigallocatechin gallate 10 µM 0.025487972950635 0.456265469568672 no 1522 0.48983287078367 2307 65064 An antioxidant.
SGTC_2644 guaiazulene 100 µM 0.0250425027262585 0.45643298631148 no 1523 0.4900105309772 2345 3515 A coloring agent.
SGTC_2882 9058044 58.44 µM 0.0249453632927601 0.456469516115669 no 1524 0.490049271901748 2335 18076804
SGTC_1994 st072947 40.9 µM 0.0236672927670458 0.456950175529646 no 1525 0.490558997642499 2302 5286565 YDL195W SEC31
SGTC_1734 st037168 69.4 µM 0.0225566015390749 0.457367937770581 no 1526 0.491001980982787 2210 708907
SGTC_1853 st056710 91.2 µM 0.0209921726720591 0.457956443320402 no 1527 0.491625949802095 2373 269167
SGTC_2957 9076800 11.52 µM 0.018812040371497 0.458776717146307 no 1528 0.492495524347864 2357 16459615
SGTC_2714 st079313 56.9 µM 0.018776417124855 0.458790121844531 no 1529 0.4925097334574 2378 2939799
SGTC_2982 9019404 25.97 µM 0.018376330706397 0.458940673878242 no 1530 0.492669317307367 2364 22333232
SGTC_340 k038-0059 454 µM 0.0178894268232841 0.459123903161258 no 1531 0.492863531919282 2382 23733424
SGTC_2313 7726885 200 µM 0.0178404824751785 0.459142322139433 no 1532 0.492883054773453 2364 726423
SGTC_1792 st045773 43.6 µM 0.0177368032021013 0.459181339523821 no 1533 0.492924410275368 2361 2919270
SGTC_1926 methyl fluorone black 53.6 µM 0.0173910121304673 0.459311473129609 no 1534 0.493062339676721 2374 72721 Reacts with homocysteine.
SGTC_1373 2887-0003 58.5 µM 0.0170225386494505 0.459450147738937 no 1535 0.493209317566962 2352 776948
SGTC_3260 9137109 49.47 µM 0.0162520629733559 0.459740131378494 no 1536 0.49351665034481 2379 17478346
SGTC_144 4161-2749 112.381 µM 0.0158401057747143 0.459895188351289 no 1537 0.493680976331474 2372 797501 YMR168C CEP3
SGTC_2368 9071271 200 µM 0.0154234933657326 0.46005200370669 no 1538 0.493847160329722 2359 27209959
SGTC_27 0485-0001 32.618 µM 0.0148487559169276 0.460268348449529 no 1539 0.494076421131436 2377 2054479
SGTC_960 1222-0186 7.7 µM 0.0131300092421814 0.460915395204571 no 1540 0.494762034673374 2370 3126296
SGTC_2286 7945697 125 µM 0.0130938976145585 0.460928991059029 no 1541 0.494776439890097 2368 1245733
SGTC_1740 st038286 13.222 µM 0.00986679029226292 0.462144164000663 no 1542 0.496063784048099 2380 716786
SGTC_1103 duloxetine 36.1 µM 0.00965475019182407 0.462224020571546 no 1543 0.496148371779602 2384 60835 A selective serotonin reuptake inhibitor.
SGTC_878 0828-0289 13.7 µM 0.00961260014079004 0.462239894913353 no 1544 0.496165186436796 2387 745350 YLR208W SEC13
SGTC_489 paxilline 115 µM 0.00897903887796064 0.462478510825792 no 1545 0.496417929887234 2373 105008 A toxic potassium channel blocker.
SGTC_1979 st071809 45.3 µM 0.00884325503034518 0.462529652370757 no 1546 0.496472097654268 2374 4976333
SGTC_1684 st024538 14.6195 µM 0.00881408526994245 0.462540638932253 no 1547 0.496483734251482 2388 6732859
SGTC_1921 5740136 50 µM 0.00881402421389609 0.462540661928564 no 1548 0.496483758608375 2388 1774243
SGTC_749 1000-0129 128 µM 0.00585166793441949 0.463656557559978 no 1549 0.497665535572894 2394 708470
SGTC_1317 1273-0028 910 nM 0.00564481344640587 0.463734488755165 no 1550 0.497748057210544 2396 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2752 diclazuril 33.15 µM 0.00523978077229351 0.463887086427762 no 1551 0.497909639475149 2393 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_252 miconazole 1.30953 nM 0.00521312390519678 0.463897129695156 no 1552 0.497920273881252 2392 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2848 9016370 25.97 µM 0.00518254419321353 0.463908650965771 no 1553 0.497932473256485 2399 7894410
SGTC_3024 9090631 49.47 µM 0.00453888559145796 0.464151164016566 no 1554 0.498189252849011 2397 25236383
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.00446129977888385 0.464180397141374 no 1555 0.498220204796595 2386 6708561
SGTC_2522 biochanin a 4.94 µM 0.0040683465295697 0.464328458767147 no 1556 0.498376969035282 2399 5280373 A possible chelator.
SGTC_2933 9026794 32.47 µM 0.00349644067504849 0.46454395711731 no 1557 0.498605124825889 2392 17586027
SGTC_892 0929-0076 29 µM 0.00349031492601139 0.464546265401205 no 1558 0.498607568631267 2400 5751038
SGTC_2171 5739187 198.077 µM 0.00341461240294526 0.464574791466648 no 1559 0.498637769388455 2395 2262761
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.00333031486733207 0.464606556500891 no 1560 0.49867139904829 2395 115019
SGTC_2466 5983409 37.09 µM 0.00276234118610367 0.46482058646197 no 1561 0.49889798670946 2387 2879657
SGTC_2189 6047310 154.431 µM 0.00137478721851666 0.465343502178656 no 1562 0.499451539424747 2392 711535
SGTC_991 3996-0057 64.7 µM 0.00120324971926566 0.46540815223888 no 1563 0.499519972928935 2399 715343
SGTC_2656 pseudo-anisatin 100 µM 0.000936413072877176 0.465508721015553 no 1564 0.499626425287905 2404 6708809 A neurotoxin.
SGTC_29 0299-0004 12.984 µM 0.000365443756896647 0.465723922558549 no 1565 0.49985420903751 2405 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3228 9131799 49.47 µM -0.000494398238956353 0.466048020731002 no 1566 0.499802763647159 2408 17015818
SGTC_3326 9140064 16.379 µM -0.000819857406418281 0.466170701157376 no 1567 0.499672924253321 2408 1868434
SGTC_2360 9040895 200 µM -0.00302225023631761 0.46700096750681 no 1568 0.498794298434259 2408 4914414
SGTC_1648 st011736 69.8 µM -0.00398181993210211 0.467362754833667 no 1569 0.498411487873755 2412 2855514
SGTC_1743 st037606 46.3785 µM -0.00494865284800145 0.467727307887722 no 1570 0.498025781205735 2419 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2035 5154463 94.595 µM -0.0054356851455736 0.467910958070889 no 1571 0.497831486051215 2417 2769623
SGTC_1046 2001-0062 216 µM -0.00678579536065723 0.468420093342779 no 1572 0.497292880100298 2414 739778
SGTC_2705 st078069 42.8 µM -0.00706414537246427 0.46852506737792 no 1573 0.497181837174772 2425 1530061
SGTC_3215 9129942 49.47 µM -0.0103316401423765 0.469757498127874 no 1574 0.495878345247597 2425 17682944
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0106990736034052 0.469896104695442 no 1575 0.495731768609497 2424 17037758
SGTC_1849 st056239 19.2 µM -0.0112302503727439 0.470096486436209 no 1576 0.495519872478194 2430 5393181
SGTC_35 0133-0054 64.071 µM -0.0128462138027519 0.470706140707627 no 1577 0.494875243123739 2447 99677
SGTC_590 k048-0076 22.4 µM -0.0129662654535347 0.470751435332835 no 1578 0.494827353433122 2432 6832814
SGTC_2359 9039622 200 µM -0.0143460676722767 0.471272051815632 no 1579 0.494276943358757 2435 6463596
SGTC_3276 9139060 49.47 µM -0.0159942476541294 0.471893994831833 no 1580 0.493619490408078 2431 4870619
SGTC_2566 crystal violet carbinol 226 nM -0.0176115466804145 0.472504351514857 no 1581 0.492974372593596 2499 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_848 0368-0089 85.6 µM -0.0186001936740181 0.472877491464791 no 1582 0.492580024166962 2443 762535
SGTC_1034 k072-0165 12.7 µM -0.0191080450536069 0.473069176473387 no 1583 0.492377456788965 2445 5835461
SGTC_858 0438-0351 2.77 µM -0.0193291245934202 0.473152623375374 no 1584 0.492289275100015 2444 2799119
SGTC_2691 st077356 60.2 µM -0.0203569249861479 0.473540584044093 no 1585 0.491879322801992 2465 2839272
SGTC_2956 9076196 2.52 µM -0.0226444554111203 0.474404140706371 no 1586 0.490966941308735 2445 16423868
SGTC_2054 5233173 129 µM -0.0234921069891719 0.474724165095651 no 1587 0.490628867229605 2487 6889
SGTC_3265 9137266 49.47 µM -0.0248931864899679 0.475253167636538 no 1588 0.490070080972525 2448 17224265
SGTC_1458 k015-0034 6.33 µM -0.0252222099600255 0.475377402672881 no 1589 0.489938860801935 2466 3598957
SGTC_2333 9017922 200 µM -0.0266072196292158 0.47590039064208 no 1590 0.489386507434057 2478 3163164
SGTC_882 0843-0131 351 µM -0.0279998033273713 0.476426280470451 no 1591 0.488831154004227 2443 5425421
SGTC_3009 9080819 71.4286 µM -0.0282059919358846 0.476504148237312 no 1592 0.488748929126599 2481 17027216
SGTC_1306 1185-0270 9.02 µM -0.0305311695576697 0.477382320175142 no 1593 0.487821717625078 2475 1548076
SGTC_2383 9036125 200 µM -0.0305618306218068 0.477393900973857 no 1594 0.487809491335669 2462 79580
SGTC_917 harmaline 728.087 nM -0.0308488730495138 0.477502318898053 no 1595 0.487695031945323 2501 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2094 5332512 191.667 µM -0.0311320764230905 0.477609288416674 no 1596 0.487582104387402 2485 755774
SGTC_1393 3470-5649 58.2 µM -0.0313873083560331 0.477705694148449 no 1597 0.487480331315181 2505 4108395
SGTC_287 k060-0039 29.6 µM -0.0316913098765119 0.477820522740193 no 1598 0.487359112560664 2479 5861974
SGTC_1017 4239-0030 168 µM -0.0320047890356882 0.477938933189327 no 1599 0.487234115878591 2484 1149593
SGTC_1292 0kpi-0043 232 µM -0.0324460999438193 0.478105632809542 no 1600 0.487058149692306 2473 3333905
SGTC_867 0518-0118 155 µM -0.0328458071728964 0.478256620472308 no 1601 0.486898774530237 2476 6848158
SGTC_1844 rapamycin 4 nM -0.0336879485976105 0.4785747459111 no 1602 0.486562994572522 2454 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_752 1896-0090 130 µM -0.0346974464738812 0.478956109516127 no 1603 0.486160498560774 2468 772567
SGTC_293 4049-0273 38.5 µM -0.0359150124801469 0.479416101772258 no 1604 0.485675062681122 2466 1380311
SGTC_2565 isoliquiritigenin 100 µM -0.0383642125434764 0.480341483563209 no 1605 0.484698647108655 2559 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_367 0335-0881 7.1 µM -0.0385282506999364 0.480403465976689 no 1606 0.484633253699796 2483 23828853
SGTC_21 0849-0113 22.993 µM -0.0385469334490656 0.480410525351417 no 1607 0.484625805893848 2456 1560156
SGTC_2028 5153890 36.43 µM -0.0387490520959936 0.480486897334339 no 1608 0.484545232417529 2474 2830968 YPR165W RHO1
SGTC_2513 baicalein 25.65 µM -0.038871802941649 0.480533279973081 no 1609 0.48449629878228 2490 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2119 5528445 120.635 µM -0.0394128881185562 0.480737737569462 no 1610 0.48428060233062 2523 791935
SGTC_799 1310-0557 151 µM -0.0402440661803694 0.481051821204971 no 1611 0.48394927316798 2577 5354492
SGTC_1618 st003135 44.5 µM -0.0416465730162211 0.481581823799114 no 1612 0.483390222764226 2473 1270615
SGTC_2482 5981709 142.65 µM -0.0422514234189984 0.48181040482478 no 1613 0.483149134585917 2532 877755
SGTC_932 2857-0803 154 µM -0.0430132851464327 0.482098331022558 no 1614 0.482845471820003 2664 674898
SGTC_112 phenothiazine 287.218 µM -0.0451466828728818 0.482904643455017 no 1615 0.481995195890692 2492 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3312 9133330 71.43 µM -0.0459044345259499 0.483191050831151 no 1616 0.481693209832266 2586 17617324
SGTC_3025 9087895 49.47 µM -0.0474073311158483 0.483759126142229 no 1617 0.481094293103055 2507 17173641
SGTC_1090 efavirenz 20.7 µM -0.0474617705116103 0.483779704149553 no 1618 0.481072599345976 2512 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2118 5526350 200 µM -0.047711503952159 0.483874103556337 no 1619 0.48097308285873 2579 743594
SGTC_1202 1988-0068 29.6 µM -0.0482071681581545 0.484061467628437 no 1620 0.480775568733677 2506 2850480
SGTC_95 0471-0001 561.058 µM -0.048459628952514 0.484156900693258 no 1621 0.480674969023951 2498 4015405
SGTC_158 k038-0087 26.446 µM -0.049563851595203 0.484574320062447 no 1622 0.480234976728519 2499 X158
SGTC_518 1021-0119 62.6 µM -0.0497794554124667 0.484655824824222 no 1623 0.480149069294113 2524 1097762
SGTC_3208 9114115 49.47 µM -0.0513528628335594 0.485250639595944 no 1624 0.479522172594178 2549 650895
SGTC_3347 9188721 44.724 µM -0.0518552563272083 0.485440572631292 no 1625 0.479322013277796 2535 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_645 0845-0943 5.41 µM -0.052252358573873 0.485590701984648 no 1626 0.479163806886185 2525 1885106
SGTC_396 dithiazanine 1.25 µM -0.0566132614187859 0.487239524271999 no 1627 0.477426635202118 2513 10578 An antihelmenthic.
SGTC_1469 k284-2957 126 µM -0.0578807727273825 0.487718802268539 no 1628 0.476921799291509 2551 23884841
SGTC_215 1287-0124 461.5 µM -0.057990817268253 0.487760413731875 no 1629 0.476877971488453 2580 5560863
SGTC_2003 4023581 200 µM -0.0581548463549723 0.48782243877624 no 1630 0.476812643601186 2582 16641307
SGTC_68 0986-0284 82.829 µM -0.0587512092328832 0.488047946581098 no 1631 0.476575135338972 2733 423278 YIL048W NEO1
SGTC_2395 5646831 180.19 µM -0.0587917785346574 0.488063287538422 no 1632 0.476558978456968 2574 6808628
SGTC_400 oxethazaine 37.5 µM -0.0594814101139992 0.488324068893473 no 1633 0.476284335918867 2564 4621 A local anesthetic.
SGTC_234 nsc-17383 10.7 µM -0.0598048706464416 0.488446385894639 no 1634 0.476155523153967 2523 408974
SGTC_1492 4158-0558 28.5 µM -0.0618520345485199 0.489220548190774 no 1635 0.475340332600079 2603 3967268
SGTC_2408 sulbentine 18.36 µM -0.0626029169225438 0.489504514696347 no 1636 0.475041353303817 2652 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_614 0462-0418 107 µM -0.0639942220666846 0.490030688370119 no 1637 0.474487413751077 2523 5188303
SGTC_850 0388-0143 75.9 µM -0.0643358632601503 0.490159895354726 no 1638 0.474351398920247 2533 67273
SGTC_206 4546-0025 72.014 µM -0.0647223967192282 0.49030608161319 no 1639 0.474197515102114 2541 6620745 YIL048W NEO1
SGTC_2655 perillic acid 100 µM -0.065528789144992 0.490611061946245 no 1640 0.473876492583213 2525 5702197 An apoptosis inducer.
SGTC_2127 5253358 187.912 µM -0.0673133357806747 0.491286002756839 no 1641 0.473166130275623 2518 20612
SGTC_2519 cryptotanshinone 88.04 µM -0.0673271915626584 0.491291243309927 no 1642 0.473160615129901 2541 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3047 9092122 49.47 µM -0.0675314401038511 0.491368494650518 no 1643 0.473079316781604 2561 17173831
SGTC_1470 k295-0292 231 µM -0.0681616517433599 0.491606856735861 no 1644 0.472828476709751 2629 5045612
SGTC_1660 st012960 28.1 µM -0.068519768808173 0.491742307067282 no 1645 0.472685941911982 2570 24207266
SGTC_1062 mesoridazine 14.2 µM -0.0694585932864779 0.492097402380001 no 1646 0.472312295392892 2521 4078 A neuroleptic.
SGTC_777 1315-0167 517 µM -0.0696458905967876 0.492168245344202 no 1647 0.472237755090026 2594 4221767
SGTC_405 ebelactone b 50 µM -0.0698026662444466 0.492227544045108 no 1648 0.472175362500182 2556 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1561 5-methoxyflavone 52.9 µM -0.0700958846309408 0.49233845120309 no 1649 0.472058671118024 2519 94525
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0710012907775509 0.492680916451436 no 1650 0.471698364096698 2622 5282362
SGTC_2103 5378138 10 µM -0.0744713143709073 0.493993482895707 no 1651 0.470317682792469 2528 244142
SGTC_1775 st081588 35.1725 µM -0.0746378147176364 0.49405646484075 no 1652 0.470251443113342 2542 1426443 YGL099W LSG1
SGTC_1151 3909-8316 15.3 µM -0.0746757484709271 0.494070814030236 no 1653 0.470236351850553 2636 800431
SGTC_2619 obliquin 87.91 µM -0.0751250325305929 0.494240765155225 no 1654 0.470057615510123 2545 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1308 1187-1617 41.4 µM -0.0754480220037653 0.494362943349898 no 1655 0.469929126013356 2528 2882570
SGTC_2828 7998861 71.43 µM -0.0761602420523314 0.494632358811558 no 1656 0.469645806514175 2551 2988188
SGTC_2653 dihydrofissinolide 100 µM -0.077433734375975 0.49511409589846 no 1657 0.46913925259242 2578 6857746
SGTC_2481 5478948 45.16 µM -0.0781296727656203 0.495377358752628 no 1658 0.468862451938596 2641 77792
SGTC_950 1165-0508 94.1 µM -0.0790315653135318 0.495718533894733 no 1659 0.468503758044259 2595 6148369
SGTC_2835 9006588 71.43 µM -0.0793393292500755 0.495834958032702 no 1660 0.468381362331295 2748 2345538
SGTC_687 k029-0044 34.9 µM -0.0797480296556911 0.495989566013061 no 1661 0.468218829463539 2555 5829338
SGTC_1198 1612-1005 86.7 µM -0.0800914785600644 0.496119490357377 no 1662 0.468082250050091 2681 6998509
SGTC_1455 4262-0120 131 µM -0.0816241961211672 0.496699311629659 no 1663 0.467472779885444 2741 1529587
SGTC_3178 9107506 49.47 µM -0.0821283253969961 0.496890023416971 no 1664 0.467272334397323 2629 8897194
SGTC_2010 4012422 159 µM -0.0829527897568148 0.497201919276426 no 1665 0.466944539243751 2613 952393
SGTC_228 caffeine 993.056 µM -0.0831405219352492 0.497272938831358 no 1666 0.46686990275924 2574 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1670 st016595 4.04 µM -0.0832998739046293 0.497333222149781 no 1667 0.466806550278537 2540 597879
SGTC_865 0488-0499 301 µM -0.083331263077128 0.497345096773226 no 1668 0.466794071197401 2541 9634651
SGTC_3120 9124077 49.47 µM -0.0833786577632116 0.497363026337645 no 1669 0.466775229025262 2537 18774327 YGL155W CDC43
SGTC_1377 2944-0135 198 µM -0.0835388382061098 0.497423623161152 no 1670 0.466711548439991 2613 1894137
SGTC_2079 5212404 121 µM -0.0843113135394965 0.497715854099387 no 1671 0.466404458763643 2564 758462
SGTC_1789 tunicamycin 25 nM -0.0873896778548747 0.498880423970283 no 1672 0.465180886933965 2644 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_888 0916-0002 6.97 µM -0.08746133227019 0.498907531561477 no 1673 0.465152409994082 2734 2802138 YIL048W NEO1
SGTC_928 2764-0428 58.7 µM -0.0876862178241993 0.498992608076895 no 1674 0.465063037004585 2691 662578
SGTC_2737 bleomycin 30.5 nM -0.0882352194160413 0.499200301203827 no 1675 0.46484486271184 2574 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2296 7971656 126.45 µM -0.088918458452265 0.4994587780765 no 1676 0.464573356967355 2607 666570
SGTC_2438 5259590 200 µM -0.0893488478014125 0.499621599243743 no 1677 0.464402337171128 2645 1201127
SGTC_1893 st059353 36.1 µM -0.0897691303899115 0.499780596969952 no 1678 0.464235339750322 2620 3112488
SGTC_1288 0973-0013 65.5 µM -0.090929036933841 0.499780596969952 no 1679 0.463774488811306 2639 4315430
SGTC_3309 9129340 25.759 µM -0.0911757901227661 0.499687247401106 no 1680 0.463676455748708 2632 17158987
SGTC_3278 9139605 49.47 µM -0.0913505027882841 0.49962115160073 no 1681 0.463607045141478 2778 7958859
SGTC_3300 9124615 50.48 µM -0.091397811855284 0.499603254041101 no 1682 0.463588250180199 2702 24824903
SGTC_2708 st078559 56 µM -0.0914978562812609 0.499565406096373 no 1683 0.463548504766321 2569 17250902
SGTC_2149 5554786 194.827 µM -0.0917439307100124 0.499472313357303 no 1684 0.463450746445737 2581 745063 YPR165W RHO1
SGTC_993 3909-8757 62.7 µM -0.0923488236234136 0.499243475660478 no 1685 0.463210449213765 2616 4288324 YLR208W SEC13
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0929986160108186 0.49899765227414 no 1686 0.462952330361109 2598 6708514
SGTC_1149 3909-7961 23.3 µM -0.0938886749267541 0.498660934135393 no 1687 0.462598795097896 2589 735261
SGTC_235 0330-0087 5 mM -0.0956044309555675 0.498011849469162 no 1688 0.461917372965016 2584 46494818 YHR062C RPP1
SGTC_3308 9128332 17.569 µM -0.0961967379508174 0.497787775979385 no 1689 0.46168216076987 2668 17332805 YDL196W YDL196W
SGTC_2090 5301565 104.445 µM -0.0975427675373084 0.497278567163584 no 1690 0.461147686276638 2600 2056344
SGTC_2878 9043973 25.97 µM -0.09792672413956 0.497133315496401 no 1691 0.460995239588085 2750 6465167
SGTC_684 1140-0066 328 µM -0.0983662055073924 0.496967059150059 no 1692 0.460820754302156 2622 6813534
SGTC_2817 7995342 71.43 µM -0.0987140490605374 0.496835469874666 no 1693 0.460682656906448 2579 18879975
SGTC_2666 tannic acid 100 µM -0.0993089415869329 0.496610422736429 no 1694 0.460446489577344 2606 16134267 A thiamine antagonist.
SGTC_3201 9113999 49.47 µM -0.0994536966413707 0.4965556622312 no 1695 0.460389025145667 2772 16649224
SGTC_1111 tnp00062 510.699 nM -0.0998917119420742 0.496389962446681 no 1696 0.460215148176082 2705 676306
SGTC_2765 myclobutanil 7.74 µM -0.102190204697439 0.495520460876004 no 1697 0.459302851285854 2677 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_113 0099-0221 2.5 µM -0.102604434797311 0.495363763059272 no 1698 0.459138461480347 2583 89219
SGTC_2116 5511452 16.8835 µM -0.103098718552592 0.495176782932201 no 1699 0.458942311025997 2697 870744
SGTC_1205 4161-2785 76 µM -0.103447999948986 0.495044655658011 no 1700 0.458803709006253 2736 3498106
SGTC_147 4466-0538 29.23 µM -0.104021726817224 0.494827625625567 no 1701 0.458576053298023 2766 6742687 YHR072W ERG7
SGTC_3078 9116413 49.47 µM -0.104443509131466 0.494668074319408 no 1702 0.458408698084924 2570 17177322
SGTC_942 3253-1115 227 µM -0.106879295789476 0.493746685354474 no 1703 0.457442369329789 2706 46497897
SGTC_680 0417-1641 114 µM -0.107117808873658 0.493656464337578 no 1704 0.457347759508625 2600 2835990
SGTC_2365 9042475 200 µM -0.107772285042833 0.493408900960168 no 1705 0.457088164072555 2646 6464479
SGTC_2297 7971671 152.32 µM -0.108839216682925 0.493005326891731 no 1706 0.456665009076044 2675 909016
SGTC_2179 6298986 200 µM -0.109303410812351 0.492829744551118 no 1707 0.456480920684829 2663 738374
SGTC_938 3126-1755 342 µM -0.10979119113902 0.492645242182601 no 1708 0.456287488631414 2605 1777771
SGTC_2541 muurolladie-3-one 83.07 µM -0.109837303377705 0.492627800360158 no 1709 0.456269203096997 2773 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1077 5-fluorocytosine 377 nM -0.110561601350727 0.492353838593571 no 1710 0.455981999213728 2681 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2123 5259487 200 µM -0.111609729263785 0.491957396334469 no 1711 0.455566428694631 2681 2173474
SGTC_1970 st070122 35.8 µM -0.111843262835391 0.491869066030751 no 1712 0.455473841957675 2736 102928
SGTC_50 0929-0078 56.389 µM -0.112526712721204 0.49161056445065 no 1713 0.455202895278594 2676 1377751
SGTC_851 0394-0702 453 µM -0.112730398431631 0.491533524982701 no 1714 0.455122150197904 2607 762646
SGTC_2060 5238662 140 µM -0.112776154501301 0.491516218837721 no 1715 0.455104011833611 2696 790130
SGTC_2367 9070478 135.38 µM -0.11569300301171 0.490413024633659 no 1716 0.453947925901049 2619 572802
SGTC_692 k241-0027 77.8 µM -0.119320920448268 0.489040997184403 no 1717 0.452510554890835 2729 3600480
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.119778968251084 0.48886777881869 no 1718 0.452329121441668 2612 97141
SGTC_2903 5923464 63.88 µM -0.119940906722133 0.488806539603534 no 1719 0.452264979740403 2626 2876576
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.120532659711875 0.48858276249074 no 1720 0.452030604760459 2867 6710655
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.1209997160008 0.488406143175076 no 1721 0.451845630070404 2625 2724 A muscle relaxant with antifungal properties.
SGTC_3158 9100007 49.47 µM -0.121132575476941 0.488355902214801 no 1722 0.451793013822921 2646 19297233
SGTC_1065 prochlorperazine maleate 2.48 µM -0.121260412838687 0.488307560547154 no 1723 0.451742387279329 2624 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2109 5483026 200 µM -0.121990832082321 0.48803135600168 no 1724 0.451453139489642 2662 759335
SGTC_3273 9137859 49.47 µM -0.122935687787888 0.487674071867983 no 1725 0.451079012595712 2616 2377234
SGTC_1225 1216-0074 20.6 µM -0.123340249696498 0.487521095378344 no 1726 0.450918834746592 2653 4241466
SGTC_1520 flindersine 88 µM -0.12448418049846 0.487088552261458 no 1727 0.450465962541872 2916 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.12466334350069 0.487020808509448 no 1728 0.450395039301347 2629 688664
SGTC_2772 vinpocetine 57.06 µM -0.127113777616487 0.48609430741394 no 1729 0.449425173479737 2752 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_820 1582-0060 59.9 µM -0.128051593364169 0.485739741945188 no 1730 0.449054071739078 2669 3848840
SGTC_986 1493-0483 84 µM -0.128721154856528 0.485486603808404 no 1731 0.448789147756406 2619 40079
SGTC_769 0302-0231 76 µM -0.129296377833855 0.48526913648121 no 1732 0.448561568723688 2702 571869 YER009W NTF2
SGTC_2929 9013348 24.6 µM -0.129594141340979 0.485156566488317 no 1733 0.448443769345021 2723 2995952
SGTC_1396 3511-0007 98.6 µM -0.130318400703275 0.48488276397832 no 1734 0.448157261278095 2737 X1396
SGTC_741 4582-0002 126 µM -0.131242881371261 0.484533279210746 no 1735 0.44779158743991 2646 2912688
SGTC_767 0929-0023 86 µM -0.132172823576338 0.484181741785656 no 1736 0.447423798076843 2652 1204563
SGTC_507 nimesulide 162 µM -0.133755655324262 0.483583427002912 no 1737 0.446797896966983 2829 4495 A COX2 inhibitor.
SGTC_1101 ebselen 5.29 µM -0.134354978746188 0.483356890665374 no 1738 0.446560940266295 2660 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2508 celastrol 40.54 µM -0.135082608962199 0.483081863282383 no 1739 0.446273280089281 2616 122724 Celastrol is a natural product and antioxidant.
SGTC_1125 tnp00248 1.32998 µM -0.135185937430058 0.483042808162447 no 1740 0.446232432665543 2801 24207736
SGTC_152 4469-0003 551.229 µM -0.1353707872582 0.482972940773612 no 1741 0.446159359946002 2653 697280
SGTC_2584 androsterone 48.74 µM -0.136712889134756 0.482465684524338 no 1742 0.445628870570306 2694 2754130 A steroid.
SGTC_3040 9091894 49.47 µM -0.138657659797735 0.481730696215893 no 1743 0.444860338700067 2676 25236966
SGTC_2452 5863136 48.41 µM -0.140023472777907 0.481214550689623 no 1744 0.444320722247556 2629 2184096
SGTC_1559 coumarin 343 70.1 µM -0.14011275536071 0.481180811574864 no 1745 0.444285451344231 2779 108770 A hepatotoxic, DNA x-linker.
SGTC_663 1486-0733 13.9 µM -0.14082541974608 0.480911506728548 no 1746 0.444003930563688 2659 722445 YPR165W RHO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.140861646346987 0.480897817488121 no 1747 0.443989620877024 2857 165506
SGTC_3258 9138477 49.47 µM -0.142179077161354 0.480400004621789 no 1748 0.443469278945681 2671 4970355
SGTC_2689 tacrolimus 100 µM -0.143244399003413 0.479997477586225 no 1749 0.44304858300904 2750 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3284 9108171 64.8615 µM -0.144269720753627 0.47961008366182 no 1750 0.442643743739611 2762 8687505
SGTC_236 1509-0011 5.31 µM -0.14476926404986 0.479421349825772 no 1751 0.442446525133685 2729 3107280
SGTC_2704 st078022 71.1 µM -0.144774406823793 0.479419406844033 no 1752 0.442444494851818 2790 54697681
SGTC_2245 6637752 200 µM -0.144937243333581 0.479357886141913 no 1753 0.442380210479997 2825 681890
SGTC_630 4356-0227 183 µM -0.14513527236056 0.479283070138624 no 1754 0.442302034899572 2671 779312
SGTC_1249 0481-0015 10.2 µM -0.145304424123718 0.479219164636397 no 1755 0.442235260926345 2663 4227577
SGTC_1884 5633444 25 µM -0.145439847356361 0.479168002151201 no 1756 0.442181802735539 2802 5724239
SGTC_2428 5615643 7.78 µM -0.14682865247937 0.478643335761345 no 1757 0.441633634186252 2751 2253075
SGTC_2948 9070189 9.45 µM -0.147092052046383 0.4785438321392 no 1758 0.44152968159552 2772 6473636 YDL196W YDL196W
SGTC_1161 k007-0610 110 µM -0.147138133754614 0.478526424135165 no 1759 0.441511495521669 2734 5843850
SGTC_2895 9054447 58.44 µM -0.147604353554229 0.478350305452956 no 1760 0.441327509550304 2674 2697450
SGTC_1330 1469-0054 61.8 µM -0.148655354571277 0.477953296016432 no 1761 0.440912795796025 2831 7102664
SGTC_1258 0671-0043 57.1 µM -0.149538476173684 0.477619718936958 no 1762 0.440564375535575 2734 4298767
SGTC_3183 9108214 49.47 µM -0.149753361901045 0.47753855359522 no 1763 0.440479603060769 2673 4974831
SGTC_968 1309-0633 340 µM -0.150466517461447 0.477269191470984 no 1764 0.440198282579277 2723 3761976
SGTC_540 1187-0821 17.3 µM -0.151374180823021 0.476926377894182 no 1765 0.439840277734198 2685 847520
SGTC_1949 st076024 69.1 µM -0.151765108430676 0.476778734466503 no 1766 0.439686101368619 2624 2921930
SGTC_998 3996-0085 177 µM -0.152440273569852 0.476523749261164 no 1767 0.439419847260751 2740 715391
SGTC_479 n-linoleoylglycine 10 µM -0.153341314162456 0.47618347414155 no 1768 0.439064560959883 2686 6433346 An anti-infammatory.
SGTC_686 1319-0111 510 µM -0.153783248146012 0.476016585508116 no 1769 0.438890321373699 2809 4562600
SGTC_524 r073-0010 27.8 µM -0.154795417482726 0.475634373374109 no 1770 0.438491301992305 2660 2772106
SGTC_3124 9127567 49.47 µM -0.15493031021555 0.475583437298958 no 1771 0.438438129026604 2846 17592030
SGTC_713 1488-1073 324 µM -0.155076094078028 0.475528389135155 no 1772 0.438380664168333 2667 3312542
SGTC_89 0302-0250 142.109 µM -0.155395494783382 0.47540778467453 no 1773 0.438254767833253 2641 4203518 YLR208W SEC13
SGTC_2523 spermine 47.74 µM -0.155585710271105 0.475335961118028 no 1774 0.438179794658694 2765 1103 A DNA binding polyamine.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.157014016315421 0.474796672124077 no 1775 0.437616900848054 2738 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_696 1560-0013 611 µM -0.15738041626905 0.474658337003092 no 1776 0.437472523335344 2859 1650269
SGTC_1134 3477-0009 42.5 µM -0.158273339188287 0.474321224788914 no 1777 0.437120707785111 2942 3973534
SGTC_2457 5731572 11.68 µM -0.158368104487579 0.474285448374934 no 1778 0.43708337275459 2841 2865357
SGTC_359 0081-0058 15.9 µM -0.158385943775042 0.474278713593943 no 1779 0.437076344608114 3052 3494159
SGTC_1616 st002734 56.1 µM -0.159517467817204 0.473851549828011 no 1780 0.436630598598202 2714 4026101
SGTC_2616 abietic acid 100 µM -0.15970890677185 0.473779282308723 no 1781 0.436555192189788 2741 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2741 miltefosine 3.04 µM -0.16102918821939 0.473280904417518 no 1782 0.436035205876296 2714 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2393 9031399 185.94 µM -0.162118096686608 0.472869896292067 no 1783 0.435606427806619 2828 1526623 YDL150W RPC53
SGTC_3230 9131665 49.47 µM -0.162527151866867 0.472715505994874 no 1784 0.435445374210485 2685 15943720
SGTC_2137 5261020 140 µM -0.16257371196493 0.472697933008113 no 1785 0.435427043202435 2682 763655
SGTC_636 0kpi-0074 126 µM -0.162597647116183 0.472688899282868 no 1786 0.435417619834478 2774 616434
SGTC_2435 5706476 10.6 µM -0.162646429798762 0.472670487520795 no 1787 0.435398414004307 2806 5725375
SGTC_948 3448-0295 75.3 µM -0.1627180914897 0.47264344077455 no 1788 0.435370200943613 2699 678569
SGTC_1412 3909-8563 178 µM -0.16302917080548 0.472526033854511 no 1789 0.435247733470718 2769 23767530
SGTC_895 0964-0006 13.7 µM -0.163885911743519 0.47220269680995 no 1790 0.434910478971232 2669 6738897
SGTC_1080 nisoldipine 24.4 µM -0.164365125187727 0.472021847944888 no 1791 0.434721858111614 2676 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3190 9110366 49.47 µM -0.16504977613578 0.471763479678592 no 1792 0.434452401786264 2761 17123768
SGTC_1901 st060216 58.6 µM -0.165700430830641 0.471517951665042 no 1793 0.434196353494586 2693 688792
SGTC_2950 9072895 21.46 µM -0.166278614900642 0.471299779908026 no 1794 0.433968847299178 2794 17332245
SGTC_1352 1496-0991 99 µM -0.167388699978809 0.470880925025484 no 1795 0.433532107924476 2691 3000039
SGTC_602 3130-1533 38.1 µM -0.167641187788732 0.47078566135497 no 1796 0.433432783271684 2828 720941
SGTC_1797 st048695 56.8 µM -0.168245083027701 0.47055781842515 no 1797 0.433195237639355 2831 592262 YIL048W NEO1
SGTC_637 1181-0519 7.26 µM -0.168679358926188 0.470393976931509 no 1798 0.433024427653962 2713 6252091 YGR060W ERG25
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.169436224869998 0.470108442233516 no 1799 0.432726766038091 2687 688667
SGTC_2938 9059746 27.26 µM -0.171109032371248 0.469477414818652 no 1800 0.432069016905016 2827 6471769
SGTC_2336 9001819 198.65 µM -0.171725843017021 0.469244756721913 no 1801 0.431826533914862 2918 2989602
SGTC_1665 st014639 11.4 µM -0.172158376011672 0.469081613554271 no 1802 0.431656510183018 2732 981133 YIL048W NEO1
SGTC_3174 9107204 49.47 µM -0.172605507752647 0.468912969476148 no 1803 0.431480761161098 2826 3938802
SGTC_3354 9151612 71.43 µM -0.172681645667201 0.468884253196102 no 1804 0.431450835841683 2832 27261949
SGTC_2017 5132927 60.65 µM -0.173228858294458 0.468677870504291 no 1805 0.431235770448275 2730 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2799 7812892 81.82 µM -0.173735223298407 0.468486901098423 no 1806 0.431036777137869 2858 20205235
SGTC_1887 st057648 70.8 µM -0.174311216626561 0.468269681033943 no 1807 0.43081044229907 2861 688672
SGTC_1089 terbinafine 2.25 µM -0.175225514197189 0.467924898239905 no 1808 0.430451218521431 2837 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_155 k072-0202 43.6 µM -0.175848583846227 0.467689951639918 no 1809 0.430206449956277 2674 5857737
SGTC_134 0269-0018 6.916 µM -0.177276938718761 0.467151391345102 no 1810 0.429645432061896 2808 4378915
SGTC_3261 9137475 49.47 µM -0.177477507306315 0.467075771878854 no 1811 0.429566665670847 2689 17027690
SGTC_2183 6420625 130.508 µM -0.177575966932536 0.467038650526564 no 1812 0.429528000076359 2716 2897619
SGTC_1260 0700-1617 7.75 µM -0.179042841009887 0.466485642240468 no 1813 0.428952031447265 2821 2853078
SGTC_589 1227-0070 34.1 µM -0.179444800015534 0.466334115831554 no 1814 0.428794228451295 2840 2841384
SGTC_1131 3454-3128 32.3 µM -0.180747159756856 0.465843199161602 no 1815 0.428283020119695 2912 710982
SGTC_64 000l-0018 272.079 µM -0.181237333002838 0.465658444726271 no 1816 0.428090646146942 2710 6811119
SGTC_101 0490-5701 117.494 µM -0.181858144180232 0.465424461313844 no 1817 0.427847026390603 2707 4661669
SGTC_700 3453-2283 142 µM -0.18398001891547 0.46462481855574 no 1818 0.427014564972427 2909 565664
SGTC_1903 st060211 78.3 µM -0.184165580160187 0.464554895299188 no 1819 0.426941780324314 2908 688960
SGTC_664 1222-0054 14.9 µM -0.184492128124481 0.464431848034463 no 1820 0.426813701006604 2755 6813991
SGTC_929 2805-0021 398 µM -0.184813903776127 0.464310602362798 no 1821 0.426687501042815 2837 3098024
SGTC_404 fumagillin 50 µM -0.184831615484144 0.464303928653982 no 1822 0.42668055475332 2768 12015870 A methionine aminopeptidase binder.
SGTC_2198 6589944 200 µM -0.185512680761171 0.464047313306632 no 1823 0.426413467541223 2762 5290268
SGTC_512 prima-1 270 µM -0.185992970629548 0.46386635615685 no 1824 0.42622513688729 2898 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1136 pergolide 1.05886 µM -0.188211834987335 0.463030459937827 no 1825 0.425355297651869 2751 47811 A dopamine receptor agonist.
SGTC_2605 digitonin 300 nM -0.188219832063731 0.463027447551851 no 1826 0.425352163292231 2763 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1276 0871-0068 94.2 µM -0.188603592789079 0.462882892790176 no 1827 0.42520175835753 2831 3414906
SGTC_2014 4013930 200 µM -0.188606949599903 0.462881628370269 no 1828 0.425200442791707 2743 64556
SGTC_2995 9067767 71.4286 µM -0.190841188089132 0.462040134937799 no 1829 0.42432500912434 2826 11673567
SGTC_2437 5741531 144.16 µM -0.191836003626884 0.461665506572141 no 1830 0.423935333941061 2915 2262990
SGTC_2207 7258803 200 µM -0.192002156917378 0.461602939749639 no 1831 0.423870257942342 2831 3666799
SGTC_972 1319-0219 195 µM -0.192916427868213 0.461258678155319 no 1832 0.423512209562576 2820 23903702
SGTC_16 erodoxin 22.806 µM -0.1952364612757 0.460385218559106 no 1833 0.422603918135409 2773 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2865 9030313 51.95 µM -0.195250532710978 0.460379921442618 no 1834 0.422598410428701 2735 42562754
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.195486371316691 0.460291142309124 no 1835 0.422506102988651 2743 688803
SGTC_1924 st058459 75.1 µM -0.195973265423478 0.46010786205778 no 1836 0.422315545669742 2734 688683
SGTC_2404 5161160 200 µM -0.198916957956631 0.458999957633956 no 1837 0.421163852028256 2729 2831543
SGTC_2954 9074818 52.69 µM -0.199577413236708 0.4587514284503 no 1838 0.420905547005755 2899 16648742
SGTC_1501 4491-0275 38.4 µM -0.200672494714159 0.45833938509333 no 1839 0.420477334120087 2755 5104718
SGTC_1817 st052116 64.4 µM -0.201265626600262 0.458116227616864 no 1840 0.420245439290017 2901 4361398
SGTC_125 0133-0007 11.75 µM -0.201883531195987 0.45788376380023 no 1841 0.420003888595609 2879 26541
SGTC_138 0850-0259 40.9225 µM -0.203938754757115 0.457110665816653 no 1842 0.419200679765969 2834 6813004
SGTC_1182 1222-0449 220 µM -0.204070826921011 0.45706099074279 no 1843 0.419149075674667 2832 658318
SGTC_1435 4092-0789 56.7 µM -0.205614082619692 0.456480590265264 no 1844 0.418546188115677 2854 2248285
SGTC_1287 0971-0001 34.6 µM -0.205963858844033 0.456349056365613 no 1845 0.41840957123695 2773 4665869
SGTC_1749 st037932 54.2 µM -0.206661697772701 0.456086647243258 no 1846 0.418137036172956 2901 594497
SGTC_342 k048-0088 23.3 µM -0.207478139422636 0.455779664132019 no 1847 0.417818231721229 2737 6820570
SGTC_1127 asiatic acid 681.4 nM -0.208432454944236 0.45542087374127 no 1848 0.417445658688405 2759 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2624 nerol 100 µM -0.210937740081865 0.454479144929075 no 1849 0.416467927150578 2758 637566 A natural product oil.
SGTC_2252 omeprazole 400 µM -0.21115308423735 0.454398209601997 no 1850 0.4163839093361 2838 4594 A proton pump inhibitor.
SGTC_2150 5556613 200 µM -0.211731599835569 0.454180788664223 no 1851 0.416158216931425 2825 743190
SGTC_261 5-fluorouridine 15.376 µM -0.212616763754499 0.453848148050875 no 1852 0.415812947407467 3005 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1035 k081-0041 55.2 µM -0.213128426395696 0.453655882284817 no 1853 0.415613396458011 2776 731709
SGTC_1039 k821-0043 94 µM -0.213293078562806 0.4535940137963 no 1854 0.4155491859275 2946 15992768
SGTC_357 1325-0123 420 µM -0.213604080820648 0.453477156946838 no 1855 0.415427908405824 2909 1098503
SGTC_391 gliotoxin 8.33 µM -0.214414024786203 0.453172845288808 no 1856 0.415112102889224 2938 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1668 st014914 51.6 µM -0.214429552032046 0.453167011669424 no 1857 0.415106049190817 2780 2839556
SGTC_2081 5214970 32.255 µM -0.214739938539232 0.453050400918563 no 1858 0.414985041213126 2864 2063512
SGTC_2595 hexamethylquercetagetin 100 µM -0.214760084273586 0.453042832400728 no 1859 0.414977187430692 2882 386331
SGTC_270 tamoxifen 5.46 µM -0.215553200450903 0.452744881470127 no 1860 0.414668019385118 2977 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_560 2332-1943 155 µM -0.217006611010974 0.452198946104449 no 1861 0.414101596430936 2773 21177716
SGTC_2278 7948257 134.34 µM -0.218409666205889 0.451672011116838 no 1862 0.413554967395688 2947 1247028
SGTC_2507 purpurin 79.67 µM -0.218696754776411 0.451564201862855 no 1863 0.413443138555827 2779 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3289 9119912 71.43 µM -0.219132047369613 0.451400744945645 no 1864 0.413273593597112 2896 17014829
SGTC_824 1304-0008 100 µM -0.219804133493688 0.451148385775339 no 1865 0.413011850148395 2810 768245
SGTC_2860 9025725 38.96 µM -0.219839375058842 0.451135153592325 no 1866 0.412998126412523 2781 40546248
SGTC_3194 9111903 49.47 µM -0.221044494190803 0.450682699172653 no 1867 0.412528894189149 2986 17087251
SGTC_3079 9117512 49.47 µM -0.221315947845511 0.450580792422279 no 1868 0.412423216632179 2749 7185044
SGTC_1303 1160-0052 261 µM -0.221556018580501 0.450490669886847 no 1869 0.412329761810752 2818 3562476
SGTC_2065 5221596 34.26 µM -0.222133940469474 0.450273728532244 no 1870 0.412104808566914 2927 788581
SGTC_747 3448-8087 38.7 µM -0.224122314069911 0.449527443179709 no 1871 0.411331064986676 2867 5168703
SGTC_5 0352-0601 109.883 µM -0.225694588119295 0.448937456425559 no 1872 0.410719483775518 2860 762456
SGTC_2871 9038510 12.99 µM -0.2259097983909 0.448856708769077 no 1873 0.410635788401499 2931 4945164
SGTC_1006 4099-6547 255 µM -0.226013785507464 0.448817693193343 no 1874 0.410595349221663 2906 3146833
SGTC_1032 k061-1018 98.7 µM -0.226556882453449 0.448613933309547 no 1875 0.41038416163588 3002 4005393
SGTC_2398 5228213 48.84 µM -0.227242698415341 0.448356647273764 no 1876 0.410117513750854 2989 80771 YMR134W ERG29
SGTC_1420 4'-methoxyflavone 42 µM -0.227742947459956 0.448168990950044 no 1877 0.409923041199626 2847 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2743 auranofin 4.32 µM -0.22782954110252 0.448136508616898 no 1878 0.409889380041952 2840 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2686 alizarin 95.37 µM -0.228456440490081 0.44790136138322 no 1879 0.409645708080494 2877 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_491 tetrandrine 80.3 µM -0.230314088299568 0.447204673581536 no 1880 0.408923856985024 2917 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_668 1682-0499 62.6 µM -0.230913527874504 0.446979895849748 no 1881 0.408690990499614 2863 682214
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.231990945314655 0.446575928936438 no 1882 0.408272523283808 2791 6708784 An antioxidant flavonoid
SGTC_841 0251-0215 91.2 µM -0.232405334245866 0.446420572681155 no 1883 0.408111603105979 2878 3888614
SGTC_2539 epi(13)torulosol 80 µM -0.232715490139699 0.446304299235377 no 1884 0.407991170014082 2925 6708597
SGTC_2844 9010103 25.97 µM -0.232729861274335 0.446298911794128 no 1885 0.407985589933595 3009 2480525
SGTC_2059 5238311 157 µM -0.234986586904366 0.445453035647659 no 1886 0.407109571934943 2818 703021
SGTC_959 1222-0044 107 µM -0.235429631608891 0.44528700065249 no 1887 0.406937644807421 2942 6083612
SGTC_2310 7668677 200 µM -0.23543106689769 0.445286462780659 no 1888 0.406937087860966 3036 2197143
SGTC_1018 4259-0013 28.1 µM -0.237119014663139 0.444653977442118 no 1889 0.4062822306998 2964 6801262
SGTC_1954 st077032 68.9 µM -0.237122697940099 0.444652597447035 no 1890 0.406280802019501 2893 698907
SGTC_1635 st007035 42.4 µM -0.238548314865438 0.444118519175251 no 1891 0.4057279234171 2831 3716403
SGTC_3233 9132340 49.47 µM -0.238904995092924 0.443984912041324 no 1892 0.40558962608982 2850 17682950
SGTC_318 1488-0629 67.2 µM -0.239089636412123 0.443915750635827 no 1893 0.405518038857753 2905 3662576
SGTC_1590 st077108 57.8 µM -0.241321214228723 0.443080000504292 no 1894 0.404653085050544 2920 5489485
SGTC_2753 fluvastatin 17.09 µM -0.243374463120127 0.442311260030452 no 1895 0.403857662322523 2912 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3199 9111318 49.47 µM -0.244481834495527 0.441896747948194 no 1896 0.403428834580977 2976 8548020
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.244990492559621 0.441706367975917 no 1897 0.403231896459973 2804 5355888
SGTC_537 1334-0398 209 µM -0.24617892659137 0.441261614773751 no 1898 0.402771863901394 3009 5846986
SGTC_620 0109-0052 432 µM -0.246259119419229 0.441231606499475 no 1899 0.402740826789524 2973 493037
SGTC_247 mechlorethamine 29.705 µM -0.247212277965839 0.440874959051724 no 1900 0.402371971855373 2818 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2101 5377231 179.231 µM -0.247882311349117 0.440624278451538 no 1901 0.402112733182403 2972 2844213
SGTC_9 0092-0002 10.449 µM -0.247958308969397 0.44059584684779 no 1902 0.402083332106937 2891 759368
SGTC_3275 9138069 49.47 µM -0.248260497333297 0.440482797657255 no 1903 0.40196643047018 2923 17617007
SGTC_3297 9117502 71.43 µM -0.248769423512114 0.440292418460902 no 1904 0.401769572089951 2868 7453720
SGTC_2967 9089538 49.85 µM -0.248939502619271 0.440228798312854 no 1905 0.401703789128598 3086 728216
SGTC_619 1652-1634 108 µM -0.251515328405037 0.439265469095617 no 1906 0.400707856330914 2886 5400454
SGTC_3091 9116372 49.47 µM -0.251560334426772 0.439248640540823 no 1907 0.400690460647017 3010 17169793
SGTC_935 2996-0153 430 µM -0.252514910453389 0.438891733435889 no 1908 0.400321545287253 3028 23738523
SGTC_279 1273-0055 2.93 µM -0.253478879858025 0.438531364649983 no 1909 0.399949089897255 2915 2847562
SGTC_2791 5663188 71.43 µM -0.254169339288885 0.438273275699694 no 1910 0.399682368321535 3020 54690634
SGTC_554 4483-2211 187 µM -0.25418721603647 0.43826659384349 no 1911 0.399675463230165 2957 747107
SGTC_1413 3910-0535 34.4 µM -0.254285966501755 0.43822968384428 no 1912 0.399637320336771 2966 2876951
SGTC_2602 kawain 100 µM -0.254810491604831 0.438033640910196 no 1913 0.399434735784136 2821 5369129
SGTC_2217 6934799 96.0675 µM -0.255580903757113 0.437745724489858 no 1914 0.399137232680903 2939 675606
SGTC_446 go6976 132 µM -0.255587795750452 0.437743148980587 no 1915 0.399134571526169 2996 3501 A protein kinase C inhibitor.
SGTC_2234 tolnaftate 200 µM -0.255627185854589 0.437728429112979 no 1916 0.399119362204725 2895 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2324 6149169 200 µM -0.255758210985976 0.437679466354424 no 1917 0.399068771835049 2927 2888231
SGTC_760 0568-0725 82.9 µM -0.258294468469866 0.436731881633839 no 1918 0.398089827493343 3007 3916171
SGTC_1943 st076331 65.2 µM -0.259772820534593 0.436179713680628 no 1919 0.397519508726857 2960 24208415
SGTC_3022 9087993 49.47 µM -0.260228801921876 0.436009428609658 no 1920 0.397343644327635 2905 17173644
SGTC_549 1661-1316 519 µM -0.260487410623254 0.435912857127449 no 1921 0.397243912545262 3002 2857282
SGTC_1859 st055998 20 µM -0.261389286212683 0.435576102328634 no 1922 0.396896159145412 3049 676301
SGTC_2413 inermin 26.06 µM -0.261980804309683 0.435355258458468 no 1923 0.396668120708018 3160 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_203 k066-0004 30.888 µM -0.262934401875285 0.434999274336711 no 1924 0.396300570041119 2895 6795412
SGTC_2448 5185112 27.17 µM -0.264050225334097 0.434582797148385 no 1925 0.395870608718066 3012 5718189
SGTC_2529 gangaleoidin 93.61 µM -0.264173218230762 0.434536894914466 no 1926 0.395823223488461 2861 4565183
SGTC_2424 5537928 59.2 µM -0.264376745492646 0.434460938352801 no 1927 0.395744814325651 2897 5382802
SGTC_2277 7947813 106.88 µM -0.266006057748005 0.433852964952587 no 1928 0.395117271824423 3104 1246798
SGTC_3189 9110682 49.47 µM -0.268353753364706 0.432977204265027 no 1929 0.394213516884055 2986 17122418
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.271441861940548 0.431825749142158 no 1930 0.393025604488368 3017 6708760
SGTC_2993 9054257 71.4286 µM -0.271690644082451 0.431733011452737 no 1931 0.392929947865811 2868 6470217 YGL055W OLE1
SGTC_268 camptothecin 39.6153 µM -0.272511862558365 0.431426915313793 no 1932 0.39261423565343 2941 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2781 5567276 71.43 µM -0.272782945376897 0.431325882530522 no 1933 0.392510035089829 3048 2853274
SGTC_920 mycophenolic acid 780.421 nM -0.27393281626539 0.430897374758399 no 1934 0.392068126038582 2928 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2920 7982904 15.77 µM -0.275942442825971 0.430148668353066 no 1935 0.391296137152073 2997 6456808
SGTC_2280 7785178 200 µM -0.276051299170081 0.430108119981627 no 1936 0.391254332676749 2904 2954328
SGTC_1415 3966-0071 78.1 µM -0.276667239929414 0.429878699435451 no 1937 0.391017814510409 2930 2893185
SGTC_245 methotrexate 289.6 µM -0.277681972525517 0.429500791851808 no 1938 0.390628250204354 2977 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.279645033913361 0.428769890499068 no 1939 0.389874926432768 3083 688798
SGTC_837 0091-0265 12.5 µM -0.279859669846347 0.428689990446399 no 1940 0.389792585031546 2903 759367
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.280454838339492 0.428468449207272 no 1941 0.389564284711159 2946 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3077 9117319 49.47 µM -0.281757814272499 0.427983517599047 no 1942 0.389064610092047 2879 17154678
SGTC_136 0097-0015 404.482 µM -0.284121515932779 0.427104091274808 no 1943 0.38815862939972 2924 4861337
SGTC_2608 thymoquinone 42.66 µM -0.287277664710886 0.425930396618073 no 1944 0.386949861590948 2976 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2874 9043904 71.43 µM -0.287947073148549 0.425681543923266 no 1945 0.386693626484957 2977 4463428
SGTC_443 clozapine 122 µM -0.288188758259112 0.425591704711589 no 1946 0.386601126767927 2920 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2966 9084041 48.03 µM -0.288335200102356 0.425537271215119 no 1947 0.386545082473116 2834 17741380
SGTC_626 0214-0009 33 µM -0.289063390707936 0.425266618573582 no 1948 0.386266434109978 3037 3437874
SGTC_3151 9099821 49.47 µM -0.289574371368531 0.425076719172138 no 1949 0.386070937997803 3040 17174189
SGTC_2724 maprotiline 69.64 µM -0.29279811335515 0.423879059394548 no 1950 0.384838235207557 3024 4011 A tricyclic antidepressant.
SGTC_2990 9074105 71.4286 µM -0.294297760193961 0.423322160975141 no 1951 0.384265192008928 2987 6502001
SGTC_1575 cyproterone acetate 48 µM -0.294399231798435 0.423284484705497 no 1952 0.384226426924783 2988 9880 An androgen receptor antagonist and liver toxin.
SGTC_772 k072-0172 35.3 µM -0.294913713136445 0.423093469281805 no 1953 0.384029898019559 2936 5861980
SGTC_271 rotenone 740 µM -0.294976077105768 0.423070316161204 no 1954 0.384006077368048 3043 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2242 6630449 61.2675 µM -0.295559202301253 0.422853839152737 no 1955 0.383783367057488 3074 691249 YDR170C SEC7
SGTC_1643 st009866 20.2 µM -0.296598246425057 0.422468166440798 no 1956 0.383386624905679 3017 3156273 YOR207C RET1
SGTC_2135 5326629 150.42 µM -0.297423848783287 0.422161772075207 no 1957 0.38307146917152 2972 5020077
SGTC_2407 paclitaxel 400 µM -0.298300828638748 0.42183636228315 no 1958 0.382736785951202 3153 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_115 0527-0192 112.043 µM -0.299580459446289 0.421361641704195 no 1959 0.382248595531507 3012 4233931
SGTC_1297 1068-0111 14.1 µM -0.299734249532435 0.421304595959875 no 1960 0.382189935840474 2933 767057
SGTC_1448 4255-0083 152 µM -0.299875269140935 0.421252288652785 no 1961 0.382136149530827 3086 5399660
SGTC_3071 9117417 49.47 µM -0.301634371524439 0.420599915568173 no 1962 0.381465401490889 2984 45595590 YGL055W OLE1
SGTC_1398 3558-0053 112 µM -0.303521860452047 0.41990017210345 no 1963 0.380746095253185 2894 4532369
SGTC_472 calcifediol 10 µM -0.304746098842438 0.419446448850882 no 1964 0.380279768358548 2988 5283731 A vitamin D metabolite.
SGTC_3225 9130819 49.47 µM -0.30502974056376 0.419341341735176 no 1965 0.380171750665409 3072 4547121
SGTC_1604 st002052 72.4 µM -0.305466352115965 0.419179560916708 no 1966 0.380005496592501 3073 6254834 YHR062C RPP1
SGTC_2815 7968870 71.43 µM -0.306174990889211 0.418917012992013 no 1967 0.379735706501659 2939 2977326 YHR190W ERG9
SGTC_2284 7945075 39.21 µM -0.306329306231861 0.418859844537918 no 1968 0.379676963944112 3081 1245402
SGTC_2071 5230951 39.92 µM -0.306849709217689 0.418667066014699 no 1969 0.379478884857627 3016 1799272
SGTC_1240 0356-0016 42.1 µM -0.307003573319686 0.418610072205187 no 1970 0.379420326182652 2973 4305613
SGTC_862 0452-0056 10.2 µM -0.307589083650381 0.418393205120322 no 1971 0.379197513871239 3025 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.308491885324035 0.418058865172679 no 1972 0.378854036969757 2922 23665772 A membrane-active detergent.
SGTC_1933 st074711 15.9 µM -0.310941281732238 0.417152064433635 no 1973 0.377922630321049 2918 17250958
SGTC_2009 4012297 12.05 µM -0.312801000935237 0.416463864362032 no 1974 0.377215927442095 3060 45595307
SGTC_653 0203-0016 55.2 µM -0.315513622249576 0.41546050237456 no 1975 0.37618585490483 2999 295302
SGTC_2930 9013230 14.89 µM -0.318046274816141 0.414524205596669 no 1976 0.375224917822079 3103 2995857
SGTC_2922 7999257 32.47 µM -0.31820743148628 0.414464643930824 no 1977 0.375163798007156 2962 2988377
SGTC_2193 5925765 200 µM -0.318860990425294 0.414223116181707 no 1978 0.374915963268464 3076 877370
SGTC_2355 9061122 103.12 µM -0.318926422507129 0.414198937035676 no 1979 0.374891153745878 3083 5302957
SGTC_2430 5571206 200 µM -0.321104535923648 0.413394243955797 no 1980 0.374065586507507 3127 1731771
SGTC_2043 5101342 149 µM -0.321736999130813 0.41316065157187 no 1981 0.373825972854919 2997 678451
SGTC_1984 st072354 53.1 µM -0.323273743582884 0.4125932024483 no 1982 0.373243968467069 2943 5762938
SGTC_1414 3917-0015 5.4 µM -0.323460969876421 0.412524080836959 no 1983 0.373173080815401 3082 6618702
SGTC_941 3237-0776 460 µM -0.323967304204233 0.412337162115705 no 1984 0.372981393934148 3162 760008
SGTC_288 1315-0019 35.1 µM -0.325765870479613 0.411673363201731 no 1985 0.37230075136319 3073 6811474
SGTC_763 3453-1109 128 µM -0.326126894318997 0.411540150113564 no 1986 0.37216417485829 3129 1560353
SGTC_185 k048-0037 25.491 µM -0.326204486618703 0.411511520897664 no 1987 0.37213482353507 3118 6827589
SGTC_1919 st067113 52.3 µM -0.328494140659838 0.410666920394038 no 1988 0.371269036901549 3116 1268243
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.330056545939133 0.410090822593554 no 1989 0.370678618164617 2964 15053
SGTC_3223 9129970 49.47 µM -0.330689221570747 0.409857594419779 no 1990 0.370439622313778 2942 17248386
SGTC_1976 st070609 63.5 µM -0.330690915523776 0.409856970007374 no 1991 0.37043898248305 2926 682556
SGTC_1281 0884-0031 11.8 µM -0.331695104083031 0.409486853755528 no 1992 0.370059748981231 3012 1548255
SGTC_2684 capsaicin 100 µM -0.331707320382564 0.409482351659819 no 1993 0.370055136251995 3088 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2658 polymyxin b sulfate 77.05 µM -0.332376468677805 0.409235767437366 no 1994 0.369802502392988 3009 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1936 st074407 74.3 µM -0.332558903847061 0.409168545464607 no 1995 0.369733634576976 2992 809813
SGTC_222 nsc-310342 10.666 µM -0.333614655458504 0.408779584685206 no 1996 0.369335178909209 3082 432556
SGTC_263 alizarin 107.927 µM -0.333629635588682 0.408774066340117 no 1997 0.369329526203783 3041 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1167 k781-0610 148 µM -0.333845858982401 0.408694416490287 no 1998 0.369247938127567 3025 4525169
SGTC_3121 9125696 49.47 µM -0.333937982157451 0.408660482375792 no 1999 0.369213178864485 3008 1235365
SGTC_1771 st048882 4.1505 µM -0.33529441219813 0.408160912774133 no 2000 0.36870150422342 2988 4580403
SGTC_1379 2144-0755 36.5 µM -0.33531585254196 0.408153017548163 no 2001 0.368693418329325 3183 5392327
SGTC_2854 9024559 71.43 µM -0.335356156912293 0.408138175904308 no 2002 0.368678218316725 3076 3163529
SGTC_2061 5245884 80.95 µM -0.335984563707738 0.407906789029664 no 2003 0.368441253452719 2986 573863
SGTC_415 dibenzyl ketone 100 µM -0.336229105147129 0.407816754632293 no 2004 0.368349053248702 3063 7593
SGTC_224 benfluorex 43.875 µM -0.338576883676441 0.40695260627235 no 2005 0.36746424962494 3105 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3154 9100113 49.47 µM -0.340652048901179 0.406189175684737 no 2006 0.366682770552278 3014 25237525
SGTC_1730 st033808 45.1 µM -0.340699074150364 0.406171879730317 no 2007 0.366665067869071 2992 1045166
SGTC_374 0880-0231 82.3 µM -0.341752712825102 0.405784397980513 no 2008 0.366268499392905 3067 6833587
SGTC_453 enantio-paf c16 10 µM -0.342334601088585 0.40557044472168 no 2009 0.366049549486699 3124 13871343 A lipid and platelet activating factor
SGTC_433 pimozide 108 µM -0.342342198923721 0.405567651276263 no 2010 0.366046690900883 2961 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2337 9009472 200 µM -0.342558430119971 0.405488153009837 no 2011 0.365965339866858 3213 5742383
SGTC_1991 st073000 8.92 µM -0.343607580467278 0.405102484082335 no 2012 0.365570711541052 3201 4301969 YIL048W NEO1
SGTC_2000 st075254 36.4 µM -0.344239785203451 0.404870129328433 no 2013 0.365332982154936 3009 17234175
SGTC_1498 4478-3555 97.6 µM -0.344315693099654 0.404842233087093 no 2014 0.365304441812825 3079 3437919
SGTC_2131 toluylene red 5.2905 µM -0.345656531803254 0.404349553124212 no 2015 0.364800427690952 3015 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1772 st048439 82.2 µM -0.347074222439257 0.4038287995049 no 2016 0.36426777935716 3104 2927068 YDL195W SEC31
SGTC_1289 0976-0073 69.1 µM -0.348981941573678 0.403128315128732 no 2017 0.363551433423696 3129 3391136
SGTC_2900 5328528 85.29 µM -0.349395225154309 0.402976604791511 no 2018 0.363396308753043 3017 795359
SGTC_484 loperamide 105 µM -0.349875617456856 0.402800278183581 no 2019 0.363216023188851 3035 3955 An opioid-receptor agonist.
SGTC_2458 5808907 16.39 µM -0.349989530582522 0.402758469597774 no 2020 0.363173277379425 3173 2731747
SGTC_2983 9022671 12.99 µM -0.353413456417965 0.401502335687454 no 2021 0.361889249566337 3215 6405161
SGTC_2453 5731132 22.18 µM -0.353708119679433 0.401394280079674 no 2022 0.361778818436638 3182 1362040
SGTC_3163 9099914 49.47 µM -0.354068730086817 0.401262051335085 no 2023 0.361643687916789 3114 16268368
SGTC_20 0481-0013 4.944 µM -0.355362130871145 0.40078787981695 no 2024 0.361159157512664 3066 182045
SGTC_2255 7941087 197.44 µM -0.355683218846516 0.400670188902256 no 2025 0.361038906848877 3171 935561
SGTC_569 4130-2812 160 µM -0.357536943105413 0.399990905292095 no 2026 0.36034493737464 3074 743552
SGTC_3098 9119039 49.47 µM -0.358968693931258 0.399466457672059 no 2027 0.359809254582895 3023 17161528
SGTC_2195 6536160 144.242 µM -0.359311308808666 0.399340985346679 no 2028 0.359681107626499 3013 3834386
SGTC_289 k017-0060 526 µM -0.359765403582321 0.399174702908463 no 2029 0.359511288573964 3053 5512909
SGTC_1253 0550-0034 176 µM -0.35985711708719 0.399141121069908 no 2030 0.359476993592322 3152 5969915
SGTC_3238 9133470 49.47 µM -0.362335293831622 0.398233994643605 no 2031 0.358550743390451 3175 3534688
SGTC_1244 0416-0015 52.5 µM -0.362391138179935 0.398213559364258 no 2032 0.358529880411569 3056 96201
SGTC_825 1988-2224 89.6 µM -0.364011005206632 0.397620918583343 no 2033 0.357924895689328 3039 1180859
SGTC_1484 3473-2379 286 µM -0.364997868721747 0.397259982693246 no 2034 0.357556498587794 3097 671917
SGTC_539 4859-0462 2.54 µM -0.365513653344626 0.39707137438325 no 2035 0.357364008463021 3196 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2702 st077768 96.8 µM -0.36587462457741 0.39693939140458 no 2036 0.357229316067346 3133 6484119
SGTC_3293 9120939 62.045 µM -0.366193745149689 0.396822720236265 no 2037 0.357110254592892 3196 934087
SGTC_500 h-89 112 µM -0.36643232587523 0.396735500641903 no 2038 0.357021251015025 3202 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2416 tofa 880 nM -0.369160749643716 0.395738420408905 no 2039 0.356003955021719 3045 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_573 3702-0553 84.7 µM -0.369216767680232 0.395717956195956 no 2040 0.355983079338141 3059 1222756
SGTC_2962 9082311 13.18 µM -0.369453946081606 0.395631314622161 no 2041 0.355894697210939 3005 16459453
SGTC_1931 st074438 57.1 µM -0.369892305094478 0.395471195091174 no 2042 0.355731367554805 3085 2787313
SGTC_216 k038-0035 28.382 µM -0.37056114860077 0.395226920424284 no 2043 0.355482211943317 3138 4444231 YPR107C YTH1
SGTC_3117 9124945 49.47 µM -0.370604841245361 0.395210964451468 no 2044 0.35546593783561 2992 17592065
SGTC_1699 st031318 29.054 µM -0.370816920623547 0.395133518379208 no 2045 0.355386948818683 3162 5340658
SGTC_634 1611-4317 11.2 µM -0.371897061243455 0.394739142439097 no 2046 0.354984746624495 3168 2843522
SGTC_3337 9144342 33.5465 µM -0.372121781185128 0.39465710727332 no 2047 0.354901089977732 3155 17682949
SGTC_3029 9088683 49.47 µM -0.373185061912847 0.394269014592721 no 2048 0.35450535664847 3194 25236615
SGTC_372 0155-0182 15.9 µM -0.37322695596723 0.394253725597803 no 2049 0.35448976767211 3026 771486
SGTC_2858 9025781 8.96 µM -0.373689146182257 0.394085062748344 no 2050 0.354317800684074 3153 4894980 YPL153C RAD53
SGTC_2976 9009005 19.48 µM -0.374273591181123 0.393871815018212 no 2051 0.354100388917018 3237 2993148
SGTC_762 1165-0429 115 µM -0.375428811546768 0.393450400888042 no 2052 0.353670790394088 3181 5967793
SGTC_1451 4152-0210 104 µM -0.375579791282022 0.393395334031247 no 2053 0.353614658433936 3220 659563
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.375911768228528 0.393274259540906 no 2054 0.353491245669502 3239 23847180
SGTC_410 α-linolenic acid 100 µM -0.375989605928147 0.393245873039426 no 2055 0.353462311654527 3187 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1277 0873-0036 22 µM -0.378592268084974 0.392297040142332 no 2056 0.352495332338098 3177 5965735
SGTC_2180 6301957 200 µM -0.378816215399264 0.392215427182469 no 2057 0.352412172556744 3203 845462
SGTC_2873 9040596 71.43 µM -0.379069223672953 0.392123229261824 no 2058 0.352318229871704 3185 6463863
SGTC_1189 1431-2119 7.28 µM -0.381825656540997 0.391119159992519 no 2059 0.351295343432292 3113 3107275
SGTC_3262 9137218 49.47 µM -0.385305793067948 0.389852508070609 no 2060 0.350005435005751 3062 17650664
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.385531929182017 0.389770242477494 no 2061 0.349921677590395 3080 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2988 9073640 71.4286 µM -0.386333167306733 0.389478801470759 no 2062 0.349624969835145 3288 9102229
SGTC_2591 skatole 100 µM -0.390410189469151 0.38799679821083 no 2063 0.34811662719584 3199 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1633 st005664 67.9 µM -0.39051737064004 0.387957859597648 no 2064 0.348077006521031 3039 2063822
SGTC_3020 9089140 49.47 µM -0.390580123633657 0.387935062137179 no 2065 0.348053809970384 3201 17217859
SGTC_1239 0337-0584 35.4 µM -0.390622831443785 0.387919547088469 no 2066 0.348038023417094 3259 914301 YML130C ERO1
SGTC_324 1315-0088 19.6 µM -0.392290365999652 0.387313899173052 no 2067 0.347421840578691 3167 6787421
SGTC_92 0063-0024 660.874 µM -0.393265655557122 0.386959801351605 no 2068 0.347061640893294 3139 3594437
SGTC_609 0986-0026 86.3 µM -0.393807757545057 0.386763021346127 no 2069 0.346861488300401 3100 2848610
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.394119972530717 0.386649702249962 no 2070 0.346746232995883 3078 16623 A steroid.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.395965688528801 0.385979993426212 no 2071 0.346065170219831 3200 521171
SGTC_2798 7813637 45.45 µM -0.396945121262173 0.385624748963588 no 2072 0.345703964900002 3230 956368
SGTC_77 0828-0286 12.516 µM -0.397010228700919 0.385601137612482 no 2073 0.34567995887985 3191 745345
SGTC_1482 3346-2049 8.48 µM -0.397498336045641 0.385424137953852 no 2074 0.345500006667921 3193 3826804
SGTC_1947 st076332 61.6 µM -0.399086345723755 0.384848452088122 no 2075 0.344914791422584 3227 24208416
SGTC_2537 larixol 68.93 µM -0.399191723749761 0.384810259371399 no 2076 0.344875970489472 3184 6708759
SGTC_2300 7976697 71.57 µM -0.399328906833789 0.384760541053588 no 2077 0.34482543511984 3056 2236109
SGTC_883 0850-0245 24.6 µM -0.402197341585577 0.383721389299076 no 2078 0.343769399266738 3297 6823229 YPR165W RHO1
SGTC_1087 pterostilbene 9.05 µM -0.402435611823252 0.383635108305533 no 2079 0.343681732956914 3227 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2845 9003024 42.97 µM -0.402927373167545 0.383457052874017 no 2080 0.34350082673385 3322 2990173
SGTC_1753 st043925 64 µM -0.40344239280208 0.383270602536882 no 2081 0.343311402815457 3204 670181
SGTC_708 3448-5400 146 µM -0.403986528242181 0.383073640900615 no 2082 0.343111312876491 3209 3462195
SGTC_819 1013-0258 27.7 µM -0.404587014675964 0.382856316882602 no 2083 0.342890552552283 3131 5753198
SGTC_1147 3809-1045 12.3 µM -0.40514624809227 0.382653956038894 no 2084 0.34268500654106 3133 325925
SGTC_1787 fluconazole 80 µM -0.40543309549297 0.382550171587975 no 2085 0.342579593962056 3209 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_497 capsazepine 133 µM -0.40545287987857 0.38254301369698 no 2086 0.342572323917072 3136 2733484 A calcium channel blocker.
SGTC_2102 5377816 72.7585 µM -0.405993273810064 0.382347517420736 no 2087 0.342373771282717 3290 1379702
SGTC_2646 retinol 96.75 µM -0.406093448827013 0.382311280775275 no 2088 0.342336969558915 3203 445354 A vitamin A analog and teratogen.
SGTC_545 4218-0007 221 µM -0.407321291318723 0.381867213012302 no 2089 0.341886013543327 3234 2840508
SGTC_1404 3909-7820 48.3 µM -0.407683487399479 0.381736248989467 no 2090 0.341753030970495 3224 23741373
SGTC_1452 4194-0072 190 µM -0.407861342248603 0.381671944615794 no 2091 0.341687737629349 3256 1343545
SGTC_2491 paeonol 100 µM -0.40841833741508 0.381470581162846 no 2092 0.341483286503462 3069 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1757 st041620 31.8375 µM -0.40879304144286 0.381335137176086 no 2093 0.341345773482257 3178 5289815
SGTC_675 1309-0189 238 µM -0.409383427076358 0.381121760412678 no 2094 0.341129149986833 3166 4246530
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.413193530471913 0.379745587316098 no 2095 0.339732413849211 3311 94937 An inhibitor of serotonin biosynthesis.
SGTC_1010 4112-3296 15.2 µM -0.414334509060696 0.379333771982532 no 2096 0.339314572140217 3287 704384
SGTC_1815 st051655 58.2 µM -0.415274202940269 0.378994709442649 no 2097 0.338970591880338 3230 5984156
SGTC_2889 9059656 51.95 µM -0.415536138093991 0.378900213967795 no 2098 0.338874732943314 3217 3949838
SGTC_53 0973-0023 39.979 µM -0.416571805284057 0.378526658599848 no 2099 0.338495817868768 3308 674768
SGTC_665 3914-0008 307 µM -0.417745862484179 0.378103324513957 no 2100 0.338066468316358 3128 1069549
SGTC_1691 st019933 84.6 µM -0.42138497000676 0.37679208989055 no 2101 0.336736996266594 3225 6176082
SGTC_2231 micatex 6.853 µM -0.421726358941954 0.376669154056565 no 2102 0.33661238123057 3208 20737 An antifungal of unknown mechanism.
SGTC_937 3122-0005 46.7 µM -0.422078640534693 0.376542308833758 no 2103 0.336483808924651 3281 759535
SGTC_3115 9123671 49.47 µM -0.422193412089226 0.376500986182179 no 2104 0.336441924847923 3270 3286988
SGTC_442 cape 100 µM -0.422312094394503 0.376458256982039 no 2105 0.336398615738505 3271 5281787
SGTC_1510 1123-0200 71.5 µM -0.422906753187519 0.376244184732407 no 2106 0.336181647738751 3350 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2113 5491891 107.031 µM -0.423032942614475 0.376198762475748 no 2107 0.336135613111176 3195 789979
SGTC_2698 st077697 67.5 µM -0.424217645145294 0.375772409000184 no 2108 0.335703546738362 3175 3154499
SGTC_1681 tripelennamine 100 µM -0.425938098458602 0.375153518401807 no 2109 0.335076476312338 3235 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1113 artemisinin 1.17947 µM -0.426416845403814 0.374981358078912 no 2110 0.334902064367547 3248 2240 An anti-malaria and mitochondrial poison.
SGTC_1011 4112-3381 17.4 µM -0.426798517451192 0.374844124323271 no 2111 0.334763043210564 3308 2877139
SGTC_1966 st070145 16.1 µM -0.428041404591847 0.374397342527333 no 2112 0.334310487988184 3098 3748532
SGTC_2739 tacrine 100.86 µM -0.429248919107835 0.373963437622856 no 2113 0.333871043023469 3257 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1980 st071811 45.7 µM -0.429989796405477 0.373697291829943 no 2114 0.3336015317897 3312 4974850
SGTC_3005 9076496 71.4286 µM -0.43011929554187 0.373650777957262 no 2115 0.333554432297374 3256 21368410
SGTC_1145 3546-0597 10.2 µM -0.430655619620393 0.373458159131694 no 2116 0.333359396449353 3197 875334
SGTC_2808 7946468 45.46 µM -0.431691711419874 0.373086140121707 no 2117 0.332982746178306 3206 2970879
SGTC_1596 piperlongumine 63 µM -0.43269057770786 0.372727599291659 no 2118 0.332619787946374 3294 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_844 0330-0132 15.3 µM -0.433354563533391 0.372489324033977 no 2119 0.33237860205234 3282 2828079
SGTC_957 1187-1561 14.1 µM -0.433791171775612 0.372332671159105 no 2120 0.332220046492574 3266 1538454
SGTC_1686 st019653 115.5 µM -0.436528570568189 0.371350988345688 no 2121 0.331226637395992 3287 97252
SGTC_954 1189-0853 2.85 µM -0.436661586324512 0.371303307643405 no 2122 0.331178395810205 3237 2828194
SGTC_740 k014-0057 261 µM -0.436859990621708 0.371232191496873 no 2123 0.331106444594755 3246 4012779
SGTC_641 4092-0595 30 µM -0.437275085899008 0.371083418738724 no 2124 0.330955930682188 3251 786260
SGTC_189 3970-0742 2.116 µM -0.437353021328873 0.3710554883379 no 2125 0.330927674272105 3320 2891807
SGTC_572 0960-0087 17.7 µM -0.440015396726058 0.370101758445249 no 2126 0.3299629779879 3216 6796365
SGTC_3330 9141424 71.43 µM -0.440129034145782 0.370061068381331 no 2127 0.329921827221973 3282 27261020
SGTC_1270 0831-1170 17.3 µM -0.442804866215955 0.369103356476056 no 2128 0.328953441619339 3252 6764716
SGTC_2412 st077135 33.4 µM -0.444208336960307 0.368601361961513 no 2129 0.328445982629808 3394 13258915
SGTC_1568 digitonin 820 nM -0.444208673794687 0.3686012415092 no 2130 0.328445860877073 3346 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_57 miconazole 162.5 nM -0.444696545487485 0.368426791658093 no 2131 0.328269533062671 3234 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2857 9024691 58.44 µM -0.44530535497629 0.368209135727897 no 2132 0.328049549258979 3254 16478292
SGTC_1118 chelidonine 707.474 nM -0.448036263116312 0.367233328000303 no 2133 0.327063512832996 3290 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1875 nocodazole 6 µM -0.448116228448672 0.367204767681379 no 2134 0.327034658259681 3326 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_621 3584-0052 32.1 µM -0.448294083809581 0.367141247715936 no 2135 0.326970484899409 3317 2273927
SGTC_1444 4112-3581 28 µM -0.44974162703161 0.366624401793356 no 2136 0.326448376123768 3226 2877249
SGTC_110 0850-0284 111.64 µM -0.450075898741075 0.36650508426254 no 2137 0.32632785721266 3086 3906265
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.450229907066375 0.366450115679703 no 2138 0.326272336879919 3236 364106
SGTC_1784 st039334 36.3 µM -0.451210764926599 0.366100092659058 no 2139 0.325918825887593 3380 3496984
SGTC_2040 5100729 123 µM -0.452308579695688 0.365708465221053 no 2140 0.32552334797635 3190 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2344 7990960 76.95 µM -0.453767027831115 0.36518840420709 no 2141 0.324998258857173 3220 140813
SGTC_3108 9121785 49.47 µM -0.453937807283277 0.36512752297395 no 2142 0.324936795361765 3278 17140271
SGTC_3185 9108267 49.47 µM -0.454416708502329 0.364956817428945 no 2143 0.324764464314341 3284 4910486
SGTC_1142 3253-1408 9.78 µM -0.45534227344267 0.364626973346738 no 2144 0.324431509076439 3324 256655
SGTC_1523 st012844 44.7 µM -0.455363166394895 0.364619528869427 no 2145 0.324423994833298 3325 4274103
SGTC_3066 9117245 49.47 µM -0.455631104829887 0.364524062847789 no 2146 0.324327635922127 3212 17176980
SGTC_3239 9133757 49.47 µM -0.455731490666632 0.364488297703337 no 2147 0.324291537113133 3257 17036923
SGTC_1257 0669-0121 16 µM -0.455739481523323 0.364485450797188 no 2148 0.32428866366708 3249 4307855
SGTC_1410 3909-8106 77.9 µM -0.456153390756115 0.364337997391013 no 2149 0.324139839638739 3302 1039210
SGTC_1809 st050081 57.6 µM -0.457623647742927 0.363814387025997 no 2150 0.323611425504472 3363 5036894
SGTC_2663 amphotericin b 100 µM -0.457675500713395 0.363795924989796 no 2151 0.323592795896846 3280 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_866 0495-0101 262 µM -0.457944815752725 0.363700041568295 no 2152 0.323496044164399 3197 635694
SGTC_2327 6189656 200 µM -0.458027282199076 0.363670682994773 no 2153 0.323466420386218 3290 5349088
SGTC_863 0466-0191 129 µM -0.458296463706311 0.363574858257034 no 2154 0.323369732201155 3305 765160 YPR165W RHO1
SGTC_2191 5911152 200 µM -0.458489257316422 0.363506231754787 no 2155 0.32330048936454 3253 2875902
SGTC_1354 1498-1681 81 µM -0.458671758097773 0.363441273106598 no 2156 0.323234948890304 3295 5754243
SGTC_2795 7780010 54.55 µM -0.458936592447361 0.363347015938363 no 2157 0.32313985018423 3320 953673
SGTC_2992 9074591 71.4286 µM -0.459249165689361 0.363235778670848 no 2158 0.323027623909434 3332 17741321
SGTC_2729 fluphenazine 10.66 µM -0.459604664565272 0.363109279225751 no 2159 0.322900005197589 3187 3372 An atypical antipsychotic.
SGTC_1826 st055655 41.6 µM -0.459809658337479 0.363036341763725 no 2160 0.322826425015273 3267 676168
SGTC_2153 5569715 200 µM -0.461024874720387 0.362604065842078 no 2161 0.322390379416817 3267 2054701
SGTC_2436 5633522 8.09 µM -0.461195261033695 0.362543470124194 no 2162 0.322329260678086 3355 5724242
SGTC_898 1000-0849 28.3 µM -0.462164409313629 0.362198870434822 no 2163 0.321981711934406 3287 6751807
SGTC_3122 9126309 49.47 µM -0.462605498878081 0.362042069339005 no 2164 0.321823583198363 3316 17591206
SGTC_717 1532-0246 73.2 µM -0.463396106989674 0.361761077299353 no 2165 0.321540234302627 3264 9561992
SGTC_2669 eugenol 100 µM -0.463440766605468 0.361745206933883 no 2166 0.321524231677385 3261 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3315 9136395 68.55 µM -0.463678318539409 0.361660793813907 no 2167 0.321439116615615 3392 16876844
SGTC_1165 k072-0275 30.3 µM -0.465924497960578 0.360862956307958 no 2168 0.32063477253041 3351 6153523 YGL055W OLE1
SGTC_2650 prasterone 100 µM -0.465943721983256 0.360856130588228 no 2169 0.320627892143774 3278 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2782 7736369 71.43 µM -0.466517034898997 0.360652589342177 no 2170 0.320422728537216 3233 2950836 YOL077C BRX1
SGTC_1796 st049173 110.4 µM -0.466986982625194 0.360485774906387 no 2171 0.320254595726273 3320 94134
SGTC_2335 9018011 154.17 µM -0.467909929301105 0.360158239535288 no 2172 0.319924501261685 3278 6458208
SGTC_1946 st076057 65.1 µM -0.468337939127351 0.360006382198791 no 2173 0.319771470706923 3261 953009
SGTC_1229 0139-0193 12.2 µM -0.469623890528664 0.359550261274859 no 2174 0.319311876483443 3356 3090752
SGTC_3232 9132874 49.47 µM -0.469974910416656 0.359425790892428 no 2175 0.319186471469969 3259 3784940
SGTC_1343 1487-0095 224 µM -0.470079667839148 0.359388647178526 no 2176 0.319149049945644 3344 4560101 YGL055W OLE1
SGTC_2564 betulinic acid 100 µM -0.471846676620196 0.358762321464368 no 2177 0.318518115698735 3440 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2100 5377183 190 µM -0.472550775425193 0.358512855545184 no 2178 0.318266854174321 3291 2844202
SGTC_1043 0916-0009 19.3 µM -0.47399757765575 0.358000435443531 no 2179 0.317750817303599 3396 3101130
SGTC_2788 5282734 71.43 µM -0.475368213395164 0.3575152274058 no 2180 0.317262273354415 3362 743706
SGTC_521 r062-0005 13.8 µM -0.47923860022619 0.356146347174247 no 2181 0.31588444834993 3278 2832033
SGTC_448 monastrol 171 µM -0.480290985681486 0.355774458491445 no 2182 0.315510248867181 3294 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_759 3486-0358 89.3 µM -0.480625809167455 0.355656168370934 no 2183 0.315391234429265 3394 875103
SGTC_2013 4024628 200 µM -0.481692750451152 0.355279320393415 no 2184 0.315012113387873 3372 5230760
SGTC_582 0987-0078 156 µM -0.482132036263311 0.355124203962509 no 2185 0.314856076578463 3384 1625765
SGTC_2952 9073731 13.78 µM -0.482630287269099 0.354948295358257 no 2186 0.314679134994503 3262 16457353
SGTC_2665 lovastatin 100 µM -0.483122454783507 0.354774564895194 no 2187 0.314504395580873 3302 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1667 st014849 34.6 µM -0.484885994682202 0.3541523002348 no 2188 0.313878608806583 3307 5348460
SGTC_1952 st077036 64.1 µM -0.485190711287222 0.354044820442652 no 2189 0.313770535199429 3334 2937007
SGTC_2045 5106652 78.05 µM -0.485363949237499 0.353983721050885 no 2190 0.313709100150191 3342 673349
SGTC_1186 1319-0216 26 µM -0.486298924437405 0.353654029051977 no 2191 0.313377620854502 3406 4565136
SGTC_681 1642-0006 26.6 µM -0.486932911084743 0.353430534392468 no 2192 0.313152937562045 3354 4446530
SGTC_2426 5582046 32.21 µM -0.48698644151126 0.3534116660163 no 2193 0.313133969685964 3391 2251934
SGTC_1905 st060207 84.5 µM -0.48711673174307 0.353365742890507 no 2194 0.313087804943499 3214 1948547
SGTC_787 4152-0075 138 µM -0.4886340637401 0.352831089401804 no 2195 0.312550396182677 3271 9566539
SGTC_3294 9122953 26.2835 µM -0.489202954530313 0.352630707467392 no 2196 0.312349009010477 3297 16459826
SGTC_2701 st077767 14.721 µM -0.489868396455947 0.35239636894913 no 2197 0.312113513880499 3301 5721188
SGTC_165 k038-0023 64.381 µM -0.490339922607356 0.35223035269189 no 2198 0.311946690611768 3261 46368543
SGTC_460 trequinsin 123 µM -0.490348601133343 0.35222729739576 no 2199 0.311943620560024 3368 5537 A vasodilator.
SGTC_1497 4476-2978 41.3 µM -0.490493408104754 0.352176319157541 no 2200 0.311892396634968 3346 1528379
SGTC_1057 3448-5381 134 µM -0.491650778108508 0.35176897101077 no 2201 0.311483120122994 3334 5497911
SGTC_2884 9058502 51.95 µM -0.493060409753325 0.351273066603896 no 2202 0.310984951762553 3361 6471554
SGTC_2256 7954252 200 µM -0.493269117910766 0.351199665158595 no 2203 0.310911223026899 3314 2972920
SGTC_1135 dihydrocapsaicin 536.708 nM -0.493518106547012 0.351112104563972 no 2204 0.310823274643122 3267 107982 A Capsaicinoid.
SGTC_579 4491-1009 110 µM -0.494031138051433 0.350931714253021 no 2205 0.310642094459612 3426 1271041
SGTC_1454 4239-0054 42.6 µM -0.494055773428729 0.350923052894337 no 2206 0.310633395481938 3438 1340767
SGTC_1417 3966-0327 90.4 µM -0.494192010339016 0.350875155828578 no 2207 0.310585290891225 3318 651118
SGTC_1866 st057638 64 µM -0.494226856292108 0.350862905352107 no 2208 0.310572987474681 3282 688802
SGTC_812 4251-0442 148 µM -0.494376956575374 0.350810137725892 no 2209 0.310519992456924 3357 5723007
SGTC_1545 lovastatin 49.4 µM -0.494686566857748 0.350701303586311 no 2210 0.310410692611049 3336 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2885 9057732 51.95 µM -0.495066845045795 0.350567645045442 no 2211 0.310276468208673 3397 6471414
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.495469110081019 0.350426278794483 no 2212 0.310134510748015 3286 6708630 An antioxidant.
SGTC_2315 7733312 200 µM -0.496711977417116 0.349989634287789 no 2213 0.309696087457023 3241 726316
SGTC_3136 9095672 49.47 µM -0.498299677456511 0.349432131536536 no 2214 0.309136417585092 3296 17217380
SGTC_657 3534-0529 86.7 µM -0.498802303659094 0.349255707680098 no 2215 0.308959332261324 3376 1049549
SGTC_365 0121-0052 13.6 µM -0.4988211602644 0.349249089567987 no 2216 0.308952689563621 3369 3101739
SGTC_3039 9090270 49.47 µM -0.499944343287914 0.34885496821102 no 2217 0.308557133797152 3407 17173750
SGTC_3263 9137018 49.47 µM -0.503103231520612 0.347747399527857 no 2218 0.307445847421249 3321 43844957
SGTC_3131 9127911 49.47 µM -0.503123762529113 0.347740205186178 no 2219 0.307438630443835 3470 45595681
SGTC_2842 9000675 19.48 µM -0.506943736535658 0.346402591453696 no 2220 0.306097148289793 3308 2989072
SGTC_1216 1165-0504 9.65 µM -0.507728360043959 0.346128081607424 no 2221 0.305821928363432 3414 6304004
SGTC_2305 7443522 69.23 µM -0.50918373943797 0.345619113962345 no 2222 0.305311719834907 3337 5415886
SGTC_237 nikkomycin 200 µM -0.510713026858503 0.345084600123683 no 2223 0.304776008808615 3428 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1267 0828-0272 9.49 µM -0.511441793838635 0.344829991395777 no 2224 0.304520868039521 3444 745334
SGTC_2133 5320837 200 µM -0.511776261963792 0.3447131620523 no 2225 0.304403802827332 3410 2841355
SGTC_3081 9117243 49.47 µM -0.512371768651096 0.34450518888838 no 2226 0.304195422652336 3429 45595589
SGTC_2797 7859098 81.82 µM -0.513428566309983 0.344136231435131 no 2227 0.303825783716712 3299 972681
SGTC_982 1491-0518 27.5 µM -0.513780612734608 0.344013355155198 no 2228 0.303702692007506 3287 3091256
SGTC_3241 9133421 49.47 µM -0.514008342089745 0.343933878569817 no 2229 0.303623079151833 3359 17018221
SGTC_2332 7982454 138.89 µM -0.516153687507224 0.343185500922119 no 2230 0.302873536702965 3388 2981748
SGTC_1009 4106-0057 9.87 µM -0.517263290889526 0.34279867022926 no 2231 0.302486187927794 3435 2928005
SGTC_2953 9074162 66.49 µM -0.519857818234238 0.341894807924287 no 2232 0.301581338659364 3376 16451992
SGTC_2989 9073649 71.4286 µM -0.520188111911356 0.341779807513487 no 2233 0.301466235160845 3424 21367202
SGTC_1974 st069448 26.9 µM -0.522385544146932 0.341015088011574 no 2234 0.300700959481731 3399 6323587 YNR016C ACC1
SGTC_907 3448-6986 75.5 µM -0.523085403274666 0.340771669753016 no 2235 0.300457411412425 3463 590582
SGTC_1697 st025554 27.742 µM -0.523968255654594 0.340464699102285 no 2236 0.300150309615373 3349 1269519
SGTC_570 0987-0065 62.6 µM -0.524821000909633 0.34016829710874 no 2237 0.299853815480001 3307 3104428
SGTC_3221 9128209 49.47 µM -0.524846341684837 0.340159490529351 no 2238 0.299845006681585 3338 16460723
SGTC_2267 7931562 200 µM -0.525049326908943 0.340088951024134 no 2239 0.299774450482675 3245 934880
SGTC_204 PMA1.184 62.41 µM -0.525858144184358 0.339807934098155 no 2240 0.299493386128997 3345 2252213 YGL008C PMA1
SGTC_3243 9134147 49.47 µM -0.527850073522319 0.339116234374482 no 2241 0.298801699720526 3416 24282180
SGTC_1107 amlodipine 47 µM -0.528536697544199 0.338877928880231 no 2242 0.298563441703049 3368 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_547 1120-0019 610 nM -0.528557680123939 0.338870647504742 no 2243 0.298556162124575 3376 3676939
SGTC_2067 5224629 34.075 µM -0.529617290870355 0.338503019688244 no 2244 0.298188651749865 3439 2835000
SGTC_698 k064-0052 127 µM -0.530742605901467 0.338112764479371 no 2245 0.297798578577443 3445 5088751
SGTC_2551 apiole 73.87 µM -0.530843212413867 0.338077882964515 no 2246 0.297763716211716 3317 10659 A possible DNA adduct former.
SGTC_1314 1222-0010 41.1 µM -0.532232645146767 0.337596291829169 no 2247 0.297282437780736 3368 3526027
SGTC_2138 5575593 77.673 µM -0.532261025201094 0.337586457789333 no 2248 0.29727261106565 3359 762213
SGTC_2910 7948405 25.97 µM -0.533202177468425 0.337260399747621 no 2249 0.296946817188828 3423 2971328
SGTC_715 0868-0130 184 µM -0.533439888676319 0.337178065069756 no 2250 0.296864555760385 3469 2876258
SGTC_2351 9026858 72.31 µM -0.533825760934211 0.33704442929719 no 2251 0.296731044497149 3313 1409300
SGTC_1473 k844-0725 134 µM -0.535468378923143 0.33647578599681 no 2252 0.296163008822312 3470 54682906
SGTC_3028 9087778 49.47 µM -0.536388658344374 0.336157365939653 no 2253 0.295844984108624 3323 17217395
SGTC_2461 5755302 26.15 µM -0.536652756414549 0.336066008730334 no 2254 0.295753747635467 3445 2788904
SGTC_2713 st079149 53.4 µM -0.537381518726324 0.335813964392149 no 2255 0.295502053304245 3402 3103253
SGTC_80 0159-0065 512.242 µM -0.537574323972626 0.335747294542784 no 2256 0.295435480190359 3408 1548079
SGTC_566 0958-0068 16.5 µM -0.538882060462735 0.335295230750644 no 2257 0.294984118192167 3438 6815365
SGTC_3349 9149703 23.001 µM -0.54172511962471 0.334313253476474 no 2258 0.294003941194962 3429 4910494
SGTC_69 0096-0274 206.684 µM -0.541803685949607 0.334286133146527 no 2259 0.293976875953446 3576 6741392
SGTC_1791 st048313 56.1 µM -0.542907108468743 0.333905333883091 no 2260 0.293596880703676 3405 1204976
SGTC_3023 9089636 49.47 µM -0.544012136114469 0.333524152011721 no 2261 0.29321656074962 3505 17249241
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.544127223145355 0.33348446234338 no 2262 0.293176964112608 3432 16486 A toxic proline analog.
SGTC_1199 1638-0010 4.46 µM -0.544365737396642 0.333402212688871 no 2263 0.293094909222749 3324 3111136
SGTC_999 SEC7.066 22.7 µM -0.544502655306921 0.333355001305153 no 2264 0.29304781083734 3382 740511 YDR170C SEC7
SGTC_344 k064-0035 6.43 µM -0.545856739516093 0.332888234671985 no 2265 0.292582208644415 3317 5088750
SGTC_3353 9151644 39.2805 µM -0.546209517016881 0.33276667114411 no 2266 0.292460962476633 3451 4909158
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.546257328089332 0.332750197288678 no 2267 0.292444532077172 3413 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2813 7971799 71.43 µM -0.546802624384515 0.332562332022368 no 2268 0.29225716994901 3425 2234054
SGTC_2095 5432005 200 µM -0.547221281858994 0.332418124842485 no 2269 0.292113358433013 3351 783734
SGTC_964 1287-0107 19.4 µM -0.547599231998496 0.332287960664869 no 2270 0.291983558440217 3474 51516812 YPR165W RHO1
SGTC_386 1509-0011 3.07 µM -0.547994029881754 0.332152015806268 no 2271 0.291848001085364 3430 3107280
SGTC_2917 7979103 53.79 µM -0.548147327526388 0.332099235186907 no 2272 0.291795372882456 3463 2980565
SGTC_1223 0764-0573 147 µM -0.548346953323884 0.332030508704844 no 2273 0.291726846514584 3424 1609797
SGTC_834 0312-0008 75.7 µM -0.548505032283533 0.331976089833608 no 2274 0.291672587421974 3441 6385573 YIL048W NEO1
SGTC_3296 9122258 64.045 µM -0.548796064144626 0.331875911036181 no 2275 0.29157270582025 3426 4730474
SGTC_474 dl-dihydrosphingosine 5 µM -0.548904882030659 0.331838456901142 no 2276 0.291535363817949 3482 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3295 9122362 53.5725 µM -0.54949484938489 0.331635424721693 no 2277 0.291332949148161 3431 4730473
SGTC_1439 4092-1168 46 µM -0.550535638211067 0.331277366819639 no 2278 0.290976020019667 3410 2886240
SGTC_3188 9110789 49.47 µM -0.551068354004265 0.331094158636397 no 2279 0.290793409039257 3493 849217
SGTC_1133 3473-0247 50 µM -0.55222945421228 0.330694980680545 no 2280 0.29039557836993 3339 711311
SGTC_1481 3346-2004 36 µM -0.552235353499161 0.330692953038939 no 2281 0.290393557733292 3446 2770522
SGTC_2354 9060492 162 µM -0.553115571374559 0.330390469397302 no 2282 0.290092137376863 3455 6471895
SGTC_2762 leflunomide 42.06 µM -0.553426591293839 0.330283615021839 no 2283 0.289985667299863 3428 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1358 1509-0022 2.48 µM -0.555624449880191 0.329528910948545 no 2284 0.289233806766049 3442 3258434
SGTC_1961 st076550 68.7 µM -0.555944867330018 0.329418943384356 no 2285 0.289124272454592 3439 1579337
SGTC_2588 indole-3-carbinol 100 µM -0.557649500232361 0.328834159994145 no 2286 0.288541873972072 3471 3712 Induces cell cycle arrest.
SGTC_3299 9121982 43.1275 µM -0.558308933055678 0.328608050313878 no 2287 0.288316723001355 3395 17594604 YPL160W CDC60
SGTC_1380 2291-0730 164 µM -0.560076660994003 0.328002232463556 no 2288 0.28771357450109 3388 2999191
SGTC_748 act1.228 77.9 µM -0.561252947931794 0.327599357770886 no 2289 0.287312556222334 3431 4421505 YNR035C ARC35
SGTC_2969 9091408 28.7 µM -0.563360603268849 0.326877994296992 no 2290 0.28659467919789 3329 4286311
SGTC_3242 9133940 49.47 µM -0.563397287222897 0.326865444609537 no 2291 0.286582192012011 3505 17248444
SGTC_3142 9086498 49.47 µM -0.564491330964713 0.326491259126652 no 2292 0.286209899150576 3394 25236367
SGTC_1706 st031321 9.9705 µM -0.56515529692279 0.326264254168805 no 2293 0.285984069795845 3473 6103185
SGTC_1493 4348-0038 111 µM -0.566841401511773 0.325688077054346 no 2294 0.28541096964139 3493 800424
SGTC_2759 disulfiram 3.38 µM -0.569332350153522 0.324837629749607 no 2295 0.284565308413151 3399 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2222 6885208 172.143 µM -0.569501605671229 0.324779876418033 no 2296 0.284507890683716 3439 609514
SGTC_2825 7998094 58.44 µM -0.569578693802178 0.324753573818349 no 2297 0.284481741373801 3413 2987815
SGTC_1687 st020778 55.3625 µM -0.570023721057794 0.324601746857588 no 2298 0.284330804713276 3461 4259299
SGTC_638 3970-0837 4.09 µM -0.571435860846552 0.324120169660321 no 2299 0.283852113099585 3427 4118451 YLR208W SEC13
SGTC_2084 5306078 60.6385 µM -0.57237304717639 0.323800726539542 no 2300 0.283534635834333 3366 679340
SGTC_2928 9011484 9.79 µM -0.575834101839872 0.322622140243061 no 2301 0.282363660484686 3475 2994751
SGTC_2440 5628896 157.78 µM -0.57744940755956 0.322072691736345 no 2302 0.281817953018769 3453 5522048
SGTC_2380 9035439 200 µM -0.578095776237992 0.321852937333857 no 2303 0.281599729266743 3552 6462575
SGTC_1038 k292-0204 154 µM -0.579552295261196 0.321357973970225 no 2304 0.281108285553311 3438 4454212
SGTC_97 0535-0701 19.132 µM -0.580462963381713 0.32104866609483 no 2305 0.280801227893379 3472 2832013 YGL099W LSG1
SGTC_161 4065-0411 162.148 µM -0.581475487433121 0.32070490864169 no 2306 0.280460017126432 3444 1906281 YLR208W SEC13
SGTC_2826 7992541 19.48 µM -0.581634653684256 0.320650884800929 no 2307 0.280406397906929 3535 2985066
SGTC_2603 homopterocarpin 100 µM -0.582919029211089 0.320215084116665 no 2308 0.279973904894853 3480 101795 A weak amylase inhibitor.
SGTC_2051 5263410 176 µM -0.583053040045276 0.320169627252623 no 2309 0.279928797519933 3545 227584
SGTC_140 0062-0056 502.533 µM -0.583389442603351 0.320055530420556 no 2310 0.279815581634359 3438 3758964
SGTC_1041 0206-0046 107 µM -0.583806086764812 0.319914241829832 no 2311 0.279675391330308 3437 50494
SGTC_1071 trifluoperazine 6.31 µM -0.585119208242651 0.319469118940266 no 2312 0.279233782047474 3553 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2322 7413319 38.22 µM -0.585696473757599 0.319273519284608 no 2313 0.279039752081148 3509 1840400
SGTC_788 1182-0090 188 µM -0.585845920001489 0.319222889369041 no 2314 0.278989531030513 3564 5715185
SGTC_962 1254-0300 21.5 µM -0.586566194762134 0.318978919487564 no 2315 0.278747546104993 3450 7340576
SGTC_921 1561-0023 372 µM -0.588122821399658 0.318451930260819 no 2316 0.278224928018016 3505 24050882
SGTC_2460 5552655 174.22 µM -0.588352872095131 0.31837407870241 no 2317 0.278147731891361 3493 5401989
SGTC_904 1141-0088 396 µM -0.588592307459781 0.318293059791503 no 2318 0.278067397728166 3472 1378119
SGTC_2306 7482397 179.52 µM -0.588631384654839 0.318279837875496 no 2319 0.278054287816441 3516 891448
SGTC_1178 0988-0033 191 µM -0.588753597838602 0.318238488079142 no 2320 0.278013288763417 3510 5392207
SGTC_429 1112-0049 25.5 µM -0.589496248168572 0.317987267338712 no 2321 0.277764214106344 3368 2836170
SGTC_910 3454-3003 490 µM -0.59153887736987 0.317296727162694 no 2322 0.277079707060027 3495 820824
SGTC_1527 coumarin 137 µM -0.592904271581452 0.316835490223435 no 2323 0.276622609574068 3531 323 A hepatotoxic, DNA x-linker.
SGTC_1998 st075797 76.8 µM -0.593490149123209 0.316637665082814 no 2324 0.27642658681171 3524 24208315
SGTC_1367 1812-0510 76.9 µM -0.593645457818163 0.316585232940548 no 2325 0.276374635092311 3460 1142582 YDR527W RBA50
SGTC_2293 7624732 200 µM -0.595005121288964 0.316126368650532 no 2326 0.275920023849539 3477 894453
SGTC_1191 1487-1166 10.6 µM -0.595786237794002 0.315862882518863 no 2327 0.27565901932158 3530 3955771
SGTC_1298 1079-1278 263 µM -0.596633635932832 0.315577144046964 no 2328 0.275376004591805 3514 2840950
SGTC_940 3232-1287 54.8 µM -0.596639814628354 0.315575061025887 no 2329 0.275373941551142 3500 1585493 YIL048W NEO1
SGTC_526 4469-0568 170 µM -0.597286436864795 0.315357097943049 no 2330 0.275158079139124 3527 2901964
SGTC_660 4031-1742 102 µM -0.598491293218997 0.314951137012611 no 2331 0.274756083391245 3458 6738706
SGTC_1005 4092-0690 4.4 µM -0.599131526690526 0.314735509423048 no 2332 0.274542589800436 3456 1529343
SGTC_182 3448-4371 550.524 µM -0.600895460150811 0.314141751889615 no 2333 0.273954808581154 3538 3491403
SGTC_1389 3405-0187 19 µM -0.601141822448357 0.314058862116152 no 2334 0.273872764804345 3449 799890
SGTC_877 0771-0151 33.1 µM -0.601302918611738 0.314004665613004 no 2335 0.273819122995947 3471 6166523
SGTC_79 0052-0007 94.094 µM -0.602240455332215 0.313689336050291 no 2336 0.273507045111156 3575 2801472
SGTC_3143 9086658 49.47 µM -0.602987749378782 0.313438089831762 no 2337 0.273258419469469 3512 25236626
SGTC_1255 0566-0045 221 µM -0.603490094853355 0.313269245909406 no 2338 0.273091351465173 3547 2788469
SGTC_1342 1486-1464 234 µM -0.603683365153989 0.313204296026479 no 2339 0.27302708790685 3549 3253938
SGTC_2177 5811945 192 µM -0.60465929970984 0.312876414694267 no 2340 0.272702698238624 3549 5343475
SGTC_2389 9091542 195.52 µM -0.605728973489461 0.312517210089288 no 2341 0.272347370536871 3472 3626624 YOL127W RPL25
SGTC_2211 7117706 200 µM -0.605805189342945 0.312491623016026 no 2342 0.272322061688307 3493 822771
SGTC_3065 9113888 49.47 µM -0.606193228469715 0.312361365114742 no 2343 0.272193224420395 3599 16648368
SGTC_3301 9125354 19.7965 µM -0.606713521740455 0.312186748620509 no 2344 0.272020523511781 3515 41905162
SGTC_1376 2910-0861 41.3 µM -0.60741325933262 0.311951975034886 no 2345 0.271788345615934 3531 1112859
SGTC_3140 9094243 49.47 µM -0.608463415486388 0.311599773544159 no 2346 0.27144008152403 3576 19291112
SGTC_2735 sertaconazole 140 nM -0.608565249277259 0.311565629674694 no 2347 0.271406322133954 3563 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.608654161512682 0.311535819600711 no 2348 0.2713768481391 3509 688761
SGTC_807 1315-0151 48 µM -0.60899772919456 0.311420641463181 no 2349 0.271262972032168 3592 4011080
SGTC_2766 oltipraz 83.91 µM -0.610962498146627 0.310762324227648 no 2350 0.270612203883715 3534 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2342 7990637 118.86 µM -0.614204340808358 0.309677433584843 no 2351 0.26954015264243 3549 2033102 YER133W GLC7
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.615355033959725 0.30929274898953 no 2352 0.269160140129642 3503 1241132 A phosphatase inhibitor.
SGTC_2642 cholecalciferol 100 µM -0.615614420527364 0.309206063128278 no 2353 0.26907451573485 3516 9821465 A vitamin D precursor, similar to steriods.
SGTC_412 gemfibrozil 100 µM -0.615706829895913 0.309175182885274 no 2354 0.269044014388398 3528 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1910 st062352 60.4 µM -0.616035976931738 0.309065203470838 no 2355 0.268935387687756 3502 2245730
SGTC_746 1095-0025 46.6 µM -0.617606675116269 0.308540614648509 no 2356 0.268417321695664 3570 6749286
SGTC_99 0109-0120 622.8 µM -0.619050284027658 0.308058816058975 no 2357 0.267941616747797 3605 759414
SGTC_22 0964-0034 14.468 µM -0.620599201590047 0.307542238769201 no 2358 0.267431682562759 3532 138402
SGTC_3313 9133968 57.047 µM -0.621271809181842 0.30731803708581 no 2359 0.267210399415504 3531 1494643
SGTC_1117 retinoic acid 1.10837 µM -0.62311350979092 0.306704507809146 no 2360 0.266604966239494 3589 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_231 b-estradiol 524 µM -0.624182361500434 0.306348687230821 no 2361 0.266253914630646 3487 450 A steroid.
SGTC_1468 k284-1086 134 µM -0.624552017059223 0.306225671413597 no 2362 0.266132560142131 3577 15996457
SGTC_409 arachidonic acid 100 µM -0.625550487462533 0.30589350467331 no 2363 0.265804911631858 3583 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3156 9099931 49.47 µM -0.625965084531659 0.305755625221135 no 2364 0.265668921518134 3533 18111053
SGTC_1938 st074717 56.4 µM -0.626028126412459 0.305734662264432 no 2365 0.265648246525766 3471 17250979
SGTC_1318 1280-3875 124 µM -0.626609741322563 0.305541291214694 no 2366 0.265457540651275 3552 373245
SGTC_2056 5235370 200 µM -0.628052852732289 0.305061730434398 no 2367 0.264984658645148 3526 5511916
SGTC_1822 st052468 42 µM -0.629649369448774 0.304531581261598 no 2368 0.264462007599083 3506 2873678
SGTC_1401 3807-4679 7.6 µM -0.629851339257897 0.304464543141172 no 2369 0.264395926224037 3564 3291456
SGTC_418 lividomycin a 100 µM -0.630108362282248 0.304379241173684 no 2370 0.264311844449747 3589 72394 An antibiotic.
SGTC_2047 4141938 200 µM -0.631549569163779 0.303901124121711 no 2371 0.263840624496794 3531 3807862
SGTC_1906 st060206 94.7 µM -0.632019839748741 0.303745185450498 no 2372 0.263686956601978 3561 5133468
SGTC_2951 9072950 58.06 µM -0.632582638682025 0.303558611930694 no 2373 0.263503113725579 3594 16488155
SGTC_2145 5634607 200 µM -0.634808326187646 0.302821276002611 no 2374 0.26277671614309 3535 308662
SGTC_1146 3579-1023 7 µM -0.636974981587994 0.302104267853806 no 2375 0.262070569998381 3590 X1146
SGTC_734 2023-0417 80 µM -0.643021308649014 0.300107409295752 no 2376 0.2601051366689 3556 3935732
SGTC_370 0180-0345 38.7 µM -0.643694520392157 0.299885444361503 no 2377 0.259886771956279 3522 3989527
SGTC_2896 9052656 71.43 µM -0.644825522681214 0.299512708504341 no 2378 0.259520130120221 3564 6469436
SGTC_1247 0448-0043 5.84 µM -0.645824890197927 0.299183529386949 no 2379 0.259196383320779 3597 3089013 YGL099W LSG1
SGTC_1723 st034307 2.5525 µM -0.649389228428142 0.298010820449988 no 2380 0.258043412291284 3603 867466
SGTC_3046 9092212 49.47 µM -0.650077227730526 0.297784702069902 no 2381 0.25782116900955 3602 25236637
SGTC_2833 9001315 45.46 µM -0.650839097172374 0.297534396825753 no 2382 0.257575179535367 3553 2989378
SGTC_628 1636-0253 16 µM -0.651118230739344 0.297442714091717 no 2383 0.257485084482462 3572 4456143
SGTC_576 1073-0113 22.7 µM -0.651611135013732 0.297280848877664 no 2384 0.257326031324761 3735 5439563
SGTC_3279 9140807 49.47 µM -0.652087972152015 0.297124298278329 no 2385 0.257172211408305 3622 45595718
SGTC_499 genistein 192 µM -0.652252446720634 0.297070308308574 no 2386 0.257119165674931 3609 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.652383193809538 0.29702739282956 no 2387 0.257077001664021 3620 66535 A nucleotide analog.
SGTC_2226 7298446 200 µM -0.65258304748795 0.296961799783672 no 2388 0.257012558745659 3601 3283010
SGTC_249 wiskostatin 11.211 µM -0.656137215492787 0.295796411354481 no 2389 0.255867920578736 3619 2775510 A n-wasp and actin depolymerizer.
SGTC_544 k015-0020 52.4 µM -0.657774733122777 0.295260187966247 no 2390 0.255341446255787 3601 3008304
SGTC_2810 7959871 45.46 µM -0.660545663204699 0.294353836638939 no 2391 0.254451862631899 3611 2974535
SGTC_3152 9099253 49.47 µM -0.663329433310727 0.293444581215121 no 2392 0.253559794895224 3629 25236131
SGTC_1999 st074831 12.5 µM -0.665270653879106 0.292811296507566 no 2393 0.252938698485965 3607 17112523
SGTC_1045 1348-1485 165 µM -0.666310103248681 0.292472457816267 no 2394 0.252606454556237 3654 6810614
SGTC_1939 st074455 53.6 µM -0.666816254932132 0.29230752899272 no 2395 0.252444754256695 3646 1644229
SGTC_2872 9044037 25.97 µM -0.667436915375859 0.292105346710598 no 2396 0.252246546320889 3610 6465195
SGTC_331 k048-0133 24.5 µM -0.667666568271991 0.292030552987219 no 2397 0.252173227464646 3602 6813582
SGTC_1767 st044992 70.3 µM -0.66979885015958 0.291336534070162 no 2398 0.251493013339941 3597 9600693
SGTC_2789 5281112 71.43 µM -0.671309044573581 0.290845459386816 no 2399 0.251011837012115 3634 765948
SGTC_2700 st077718 96.8 µM -0.672320226935886 0.290516866457988 no 2400 0.250689927794825 3621 904970
SGTC_2117 5521686 200 µM -0.672500746591956 0.290458223231271 no 2401 0.250632482494035 3625 803312
SGTC_481 bay k-8644 50 µM -0.672716809102877 0.290388040915064 no 2402 0.250563735848032 3578 2303 A calcium channel antagonist.
SGTC_3146 9095609 49.47 µM -0.673840074370476 0.290023305252459 no 2403 0.250206496982844 3655 17173999
SGTC_1503 4585-0012 61.3 µM -0.674057070946857 0.289952869015239 no 2404 0.250137515389713 3646 2922052
SGTC_1819 st053448 58.6 µM -0.675211416501548 0.289578307875907 no 2405 0.249770727179278 3592 2857616
SGTC_2201 6605497 169.863 µM -0.676996293623626 0.288999599965615 no 2406 0.249204152988118 3636 670741
SGTC_1644 st010134 20.9 µM -0.679679104490775 0.288130781345094 no 2407 0.248353834779247 3630 3818134
SGTC_345 1362-0200 395 µM -0.681378973488601 0.287580923500152 no 2408 0.247815861989247 3621 1419823
SGTC_1015 4130-4525 82 µM -0.68145522628993 0.287556269581055 no 2409 0.247791744169202 3643 1363237
SGTC_1636 st007707 68.9 µM -0.681754387161499 0.287459555075445 no 2410 0.2476971353811 3669 403051
SGTC_1617 st002906 78 µM -0.684403257677048 0.286603884313963 no 2411 0.246860279743516 3662 5150859
SGTC_1509 1326-1131 80 µM -0.685090585185701 0.286382052882909 no 2412 0.246643380444784 3604 768313
SGTC_515 4092-1064 102 µM -0.685284547367748 0.286319467329897 no 2413 0.246582190451505 3678 717353
SGTC_123 0083-0120 66.675 µM -0.685336390923437 0.286302740129535 no 2414 0.246565836543564 3606 16001701
SGTC_2184 6075246 200 µM -0.688231371907861 0.285369418516474 no 2415 0.245653545510856 3688 2267320
SGTC_3211 9128781 49.47 µM -0.688518680436462 0.285276871356322 no 2416 0.245563105386036 3645 17194361
SGTC_2377 9073351 62.6 µM -0.690571284334476 0.284616107666365 no 2417 0.244917499203312 3629 7337946 YHR072W ERG7
SGTC_2837 9008476 45.46 µM -0.690993279484123 0.284480351774822 no 2418 0.244784882212861 3675 2992805
SGTC_1917 st066507 28.5 µM -0.691045098348902 0.284463683772222 no 2419 0.244768600184013 3631 3156428
SGTC_677 0929-0063 136 µM -0.691158089342116 0.2844273408237 no 2420 0.24473309925486 3619 1539583
SGTC_2261 9010538 184.68 µM -0.691202408540913 0.284413086396233 no 2421 0.244719175249386 3590 6457250
SGTC_3172 9105863 49.47 µM -0.691811667930503 0.284217164306824 no 2422 0.244527804131027 3641 2348785
SGTC_3062 9077494 49.47 µM -0.692772561243367 0.283908297028736 no 2423 0.244226147120017 3629 16459633
SGTC_1162 k048-0130 20.1 µM -0.693367924688419 0.283717005446301 no 2424 0.244039343047066 3655 6797406
SGTC_3054 9094397 49.47 µM -0.693986384061816 0.283518358478726 no 2425 0.243845373928207 3664 2598354
SGTC_605 1315-0399 119 µM -0.697278620682273 0.282462027004434 no 2426 0.242814222466117 3714 24020461
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.697915539883948 0.282257886829865 no 2427 0.242615007709765 3713 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1878 temozolomide 1 mM -0.698123997284656 0.282191089179701 no 2428 0.242549825904188 3629 5394 DNA alkylating agent.
SGTC_568 1193-0097 7.48 µM -0.698781017890219 0.28198060468014 no 2429 0.242344446527672 3574 3646150
SGTC_2545 solidagenone 89.61 µM -0.699817025412468 0.28164886085016 no 2430 0.242020790416532 3516 6708572 An anti ulcer agent
SGTC_774 k060-0086 136 µM -0.700533961126251 0.281419398426841 no 2431 0.241796951925017 3698 5911235
SGTC_1959 st077091 55.8 µM -0.700737701826912 0.281354205649169 no 2432 0.241733361412059 3693 821356 YKL052C ASK1
SGTC_3169 9102970 49.47 µM -0.702450566733492 0.280806413014145 no 2433 0.241199109821345 3741 17027839
SGTC_3160 9100216 49.47 µM -0.702848173792846 0.280679327785006 no 2434 0.24107518592671 3618 17191039
SGTC_2778 tioconazole 65.09 nM -0.703051557788924 0.280614331895302 no 2435 0.241011809751371 3638 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_880 0833-0487 87.2 µM -0.704961978758619 0.280004170004868 no 2436 0.240416948894057 3670 76075
SGTC_1347 1493-0251 600 nM -0.706929426218111 0.279376467689177 no 2437 0.239805168127231 3716 3986378
SGTC_43 0570-0105 72.5 µM -0.708809612297841 0.27877724508312 no 2438 0.239221315970402 3722 1114046 YDL195W SEC31
SGTC_2484 5809818 12.04 µM -0.710465608075517 0.278249991454674 no 2439 0.238707725382533 3691 2870548
SGTC_186 3455-3465 67.277 µM -0.711752231644531 0.277840678397515 no 2440 0.238309108738797 3648 755278
SGTC_2163 5671233 125 µM -0.712500518011036 0.277602761615937 no 2441 0.238077445394399 3729 701023
SGTC_157 1348-1695 65.819 µM -0.713555393594182 0.277267534307414 no 2442 0.237751074280721 3697 5380510
SGTC_2471 5466956 24.79 µM -0.71401071239524 0.27712290043715 no 2443 0.237610277697792 3666 724419
SGTC_86 0417-1630 471.922 µM -0.716521635576102 0.276325959284187 no 2444 0.23683465649962 3735 3634867
SGTC_1579 chlormadinone acetate 49.4 µM -0.717571843803307 0.275992967801187 no 2445 0.236510661796867 3702 45114258 A steroidal progestin.
SGTC_2007 4011539 71.82 µM -0.718090468843622 0.275828599111071 no 2446 0.236350753287815 3707 45595301
SGTC_1200 1643-0193 18.4 µM -0.718741777819785 0.275622246837523 no 2447 0.236150018466017 3705 5403974
SGTC_109 0132-0036 33.701 µM -0.719469262679422 0.275391849762169 no 2448 0.235925917146502 3574 67274 A color developer.
SGTC_1139 k015-0024 46.9 µM -0.720200391821333 0.275160394046651 no 2449 0.23570081135511 3682 2766652
SGTC_1462 k081-0014 26.5 µM -0.720494731992136 0.27506724095868 no 2450 0.235610221040723 3484 3270634
SGTC_1284 0929-0043 16 µM -0.720927635172732 0.274930263531908 no 2451 0.235477019508718 3704 1239883
SGTC_1857 st056007 79.3 µM -0.721454137366444 0.274763715205677 no 2452 0.235315074178224 3706 619834
SGTC_1724 st037281 8.293 µM -0.721808347518262 0.27465169598016 no 2453 0.235206158278152 3726 574124 YDL195W SEC31
SGTC_1562 morin hydrate 59.1 µM -0.721880928444594 0.274628744988764 no 2454 0.235183843842881 3744 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3331 9141060 1.957 µM -0.72281198192944 0.274334418224766 no 2455 0.234897702477484 3708 4906567 YPR165W RHO1
SGTC_1474 0330-0125 5.35 µM -0.72446881853607 0.27381104067433 no 2456 0.234388981798066 3712 X1474
SGTC_2200 6600604 21.907 µM -0.7252708508063 0.273557864455676 no 2457 0.234142942281441 3676 2904777
SGTC_1985 st071382 65.5 µM -0.726475675818271 0.27317775718044 no 2458 0.233773606924361 3739 6123237
SGTC_107 0358-0022 2.6945 µM -0.726994882057995 0.273014034808358 no 2459 0.233614545481296 3725 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1744 st037937 38.9 µM -0.727396875628188 0.272887306768591 no 2460 0.23349143395844 3758 1016152
SGTC_1366 1683-0113 21.9 µM -0.727925531768821 0.272720692912457 no 2461 0.233329586504311 3734 708623
SGTC_1986 st071812 45 µM -0.728493780568137 0.272541657147828 no 2462 0.233155687245605 3682 11838594
SGTC_3135 9127742 49.47 µM -0.728588833946899 0.272511714776491 no 2463 0.233126605407364 3771 3643468
SGTC_3097 9117246 49.47 µM -0.729176926794423 0.272326498405251 no 2464 0.232946721591911 3749 16423892
SGTC_1909 st060837 51.5 µM -0.729297367999498 0.272288573875827 no 2465 0.232909890964446 3734 678937
SGTC_951 1171-0579 82.7 µM -0.730220969064528 0.271997837600644 no 2466 0.232627563545149 3704 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_371 0195-0006 7.36 µM -0.730549180457848 0.271894558586555 no 2467 0.232527281348461 3615 3928593
SGTC_3316 9136639 10.545 µM -0.731863336835495 0.271481225598606 no 2468 0.232125992961705 3758 4903665
SGTC_1988 st071872 53.4 µM -0.732448302110645 0.271297341028196 no 2469 0.231947493091346 3734 16414116
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.733511422336475 0.270963306856781 no 2470 0.231623281883904 3688 4620898
SGTC_229 benomyl 22.8748 µM -0.734249641602998 0.270731477891554 no 2471 0.231398301767154 3742 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3053 9095903 49.47 µM -0.73435086326431 0.270699698156838 no 2472 0.231367462900008 3781 17174018
SGTC_1219 1469-0211 33.1 µM -0.737188238964872 0.269809629233179 no 2473 0.230503942301793 3704 6822282
SGTC_145 3737-0113 38.366 µM -0.737768611070516 0.269627750428586 no 2474 0.230327535322844 3752 6849351
SGTC_317 4495-0002 170 µM -0.738643980523395 0.269353540682917 no 2475 0.230061605296906 3756 15991618
SGTC_2260 7964312 200 µM -0.74007072580416 0.268906912175868 no 2476 0.229628540275242 3756 231951
SGTC_2534 helenine 20.12 µM -0.741062506924233 0.268596664130803 no 2477 0.229327770703405 3758 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_314 1671-0008 2.74 µM -0.741577944673814 0.268435496445765 no 2478 0.229171545252506 3680 3913060
SGTC_1860 st056228 74.6 µM -0.741795206038894 0.268367577476116 no 2479 0.229105712790908 3699 688679
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.743652689702605 0.267787254901644 no 2480 0.228543309072165 3801 688788
SGTC_70 0141-0289 43.283 µM -0.74529291161681 0.267275336295633 no 2481 0.228047332661441 3783 352408
SGTC_456 gingerol 170 µM -0.746345765789238 0.266946997499144 no 2482 0.227729285964372 3783 442793 A herb.
SGTC_2157 5649910 96.377 µM -0.746638261527643 0.266855817150454 no 2483 0.227640973045897 3719 2858091
SGTC_430 0958-0115 16.4 µM -0.749142544004336 0.266075796246771 no 2484 0.226885647486799 3736 6833180
SGTC_721 1187-1332 279 µM -0.751210720273927 0.26543248316227 no 2485 0.22626292475408 3690 25730
SGTC_2019 4016004 108 µM -0.751468896260891 0.265352232112691 no 2486 0.226185256454894 3768 45595336
SGTC_2237 6667747 47.222 µM -0.752364909798504 0.265073812130223 no 2487 0.225915821377928 3721 729940 YDL015C TSC13
SGTC_399 oxolinic acid 75 µM -0.754714535299108 0.264344414021308 no 2488 0.225210141613135 3738 4628 A DNA gyrase inhibitor.
SGTC_3082 9117008 49.47 µM -0.755597849533921 0.264070469837641 no 2489 0.224945172828699 3824 41448529
SGTC_2295 7971645 200 µM -0.75850834069412 0.263168857462629 no 2490 0.22407336087501 3803 2978226 YKL099C UTP11
SGTC_2158 5657123 3.6195 µM -0.758825180358856 0.263070801830835 no 2491 0.223978570327479 3746 2858827
SGTC_3015 9080845 49.47 µM -0.758835064471857 0.263067743192997 no 2492 0.223975613613202 3835 5296973
SGTC_658 3253-0951 102 µM -0.759864692213181 0.262749224565357 no 2493 0.223667734280604 3778 1184878
SGTC_2316 5844804 197.44 µM -0.761832775544482 0.262140941100202 no 2494 0.223079908024883 3849 776813
SGTC_1756 st041558 35.5 µM -0.766524660503902 0.260693717725869 no 2495 0.22168209213372 3826 3955792
SGTC_2478 5763493 32.33 µM -0.766611395506181 0.260667002863391 no 2496 0.221656299067223 3745 1365576 YLR208W SEC13
SGTC_1659 st012954 42.1 µM -0.767259123633745 0.260467543562215 no 2497 0.221463733314981 3775 24207262
SGTC_3170 9103054 49.47 µM -0.769870935342857 0.25966406890555 no 2498 0.220688228145094 3795 16432970
SGTC_706 4262-0057 46.9 µM -0.770019518484677 0.259618398593748 no 2499 0.220644157305972 3766 883298
SGTC_1172 0370-0043 85 µM -0.770497671129454 0.259471455963273 no 2500 0.220502367980354 3825 376585
SGTC_1960 st011366 51.8 µM -0.771686775666157 0.259106214744808 no 2501 0.220149982515485 3784 3972846
SGTC_635 k038-0028 24.7 µM -0.772702334935062 0.258794489678624 no 2502 0.219849282248641 3805 4035102
SGTC_924 2046-0044 21.3 µM -0.773613332274564 0.25851502503392 no 2503 0.219579742758192 3778 3623589
SGTC_2941 9056145 11.23 µM -0.774457263854658 0.258256273539777 no 2504 0.219330215650177 3664 2119517
SGTC_2722 naftopidil 47.16 µM -0.774610514826265 0.258209300821238 no 2505 0.219284921086945 3732 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2023 5144124 124 µM -0.775057223493447 0.258072406111905 no 2506 0.21915292340889 3792 2830192
SGTC_1709 st033179 39.1045 µM -0.775261308647896 0.258009876361365 no 2507 0.219092633613862 3762 573381
SGTC_3161 9100388 49.47 µM -0.775414468318975 0.25796295485686 no 2508 0.219047394230319 3809 25236368
SGTC_292 k038-0015 474 µM -0.775826157536844 0.257836853015727 no 2509 0.218925818572363 3777 46368540
SGTC_1278 0874-0585 172 µM -0.776829573850584 0.257529637158829 no 2510 0.218629663046076 3853 766306
SGTC_307 1501-1223 22.3 µM -0.777129912762125 0.257437719414129 no 2511 0.2185410637204 3794 2830329
SGTC_870 0573-2213 57.6 µM -0.78075729821764 0.256328917494162 no 2512 0.217472626745369 3796 3916321
SGTC_2144 5628481 200 µM -0.780981923829674 0.256260336940438 no 2513 0.217406563148892 3793 2818399
SGTC_40 0327-0103 19.753 µM -0.781054794674223 0.256238090762878 no 2514 0.217385133932361 3705 409036
SGTC_2487 5918373 44.05 µM -0.781965015841135 0.255960301224428 no 2515 0.217117566880017 3816 2876279
SGTC_2945 9067681 61.76 µM -0.782612676484192 0.25576273800613 no 2516 0.216927297586919 3880 16456930
SGTC_2472 5377652 49.4 µM -0.78481429703557 0.255091748636434 no 2517 0.216281228168633 3874 1610903
SGTC_384 k007-0144 5.16 µM -0.786764814242198 0.254498058334869 no 2518 0.215709777223744 3800 6824886
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.787919684319469 0.25414688531356 no 2519 0.215371843204753 3815 676296 Flavone; oxidizing agent.
SGTC_2725 haloperidol 53.21 µM -0.788343601534602 0.254018044314827 no 2520 0.215247875149993 3780 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3167 9103034 49.47 µM -0.791019208145607 0.253205639609277 no 2521 0.214466391367378 3839 5127859
SGTC_2864 9034755 47.6 µM -0.791241910437502 0.25313808130753 no 2522 0.214401419553012 3794 4930451
SGTC_872 0588-0139 234 µM -0.792296250950928 0.252818368458074 no 2523 0.214093978597063 3803 2047100
SGTC_662 k832-1615 104 µM -0.792540213745772 0.252744420718896 no 2524 0.214022876710392 3867 5878478
SGTC_3003 9075612 71.4286 µM -0.793381468537512 0.25248951474518 no 2525 0.213777802127307 3847 6501993
SGTC_1622 st003707 19.4 µM -0.795100471693632 0.251969066518667 no 2526 0.213277530150855 3877 10140899
SGTC_3321 9137793 26.8275 µM -0.797088708585929 0.251367811446324 no 2527 0.212699756809095 3785 4904192
SGTC_2849 9019321 12.99 µM -0.79709097150015 0.251367127559482 no 2528 0.212699099736767 3831 16489627
SGTC_1000 4048-0884 8.67 µM -0.797805969896833 0.251151093508774 no 2529 0.212491548189866 3832 13040088
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.798878277008283 0.250827284159463 no 2530 0.21218049803727 3863 688664
SGTC_864 0469-0573 172 µM -0.799834112598629 0.250538832655671 no 2531 0.21190345795097 3817 689425
SGTC_683 panaxydol 45 µM -0.800850071454728 0.250232429982233 no 2532 0.211609223809319 3798 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1432 4049-0298 68.4 µM -0.802019382634353 0.249880023952539 no 2533 0.211270873169181 3839 741646
SGTC_1828 st055811 49 µM -0.802837178119828 0.24963371407114 no 2534 0.211034425201982 3860 5877589
SGTC_2106 5357045 167.29 µM -0.80394629917975 0.249299866700722 no 2535 0.210713994687782 3872 668842
SGTC_724 3910-0327 137 µM -0.804360521543814 0.249175245955456 no 2536 0.210594397054648 3876 2885483
SGTC_2485 5633444 17.78 µM -0.804556671235144 0.249116244960259 no 2537 0.210537777028099 3871 5724239
SGTC_447 ml7 120 µM -0.804609113788079 0.249100471721906 no 2538 0.210522640619729 3862 4216 Selective myosin light chain kinase inhibitor.
SGTC_347 4534-1311 26.2 µM -0.805225081452783 0.248915245824133 no 2539 0.210344902689377 3831 2862016
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.806465492589729 0.248542467847855 no 2540 0.209987248597067 3778 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1124 fisetin 1.16336 µM -0.806597816029184 0.248502718546381 no 2541 0.209949116207676 3855 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_541 4513-1321 94 µM -0.807028623114774 0.248373329715708 no 2542 0.209824996303057 3847 747515
SGTC_2390 9097792 176.6 µM -0.807357816221597 0.248274483891049 no 2543 0.209730181499978 3866 4497149
SGTC_1883 5-benzylidenerhodanine 20 µM -0.809011072706713 0.247778382873045 no 2544 0.209254388622421 3861 1273210
SGTC_1370 2001-0092 44.6 µM -0.809546972111826 0.247617686494596 no 2545 0.209100297880669 3897 790957
SGTC_2396 5342950 42.78 µM -0.81020376868964 0.247420813481281 no 2546 0.208911535920633 3859 1886677
SGTC_1155 4088-0394 48.2 µM -0.81217777863236 0.246829613184112 no 2547 0.208344814176345 3830 2326248
SGTC_801 0866-0028 10.1 µM -0.812587346217099 0.246707045739374 no 2548 0.208227344446468 3850 6849771
SGTC_1301 naphtanilide LB 4.81 µM -0.813384412511006 0.246468608656507 no 2549 0.207998846712697 3900 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2074 5212007 75.395 µM -0.813406627199761 0.246461965049207 no 2550 0.207992480472517 3723 758611
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.813865218413648 0.246324838498076 no 2551 0.207861084038398 3878 229346 A bile salt which induces apoptosis.
SGTC_776 4476-4378 112 µM -0.815597243160686 0.245807302855231 no 2552 0.207365263366525 3923 2892008
SGTC_1925 st057770 10.1 µM -0.818133113417517 0.24505062923684 no 2553 0.206640591342688 3852 5989122
SGTC_197 4544-0043 41.561 µM -0.818521365022835 0.244934890263647 no 2554 0.206529773773739 3850 896523
SGTC_742 0kpi-0133 140 µM -0.818876774717158 0.244828967355682 no 2555 0.206428361048968 3922 2728852
SGTC_1359 1582-0056 520 nM -0.819460343966229 0.244655099445547 no 2556 0.206261909208475 3948 3661189
SGTC_1608 st001473 40.5 µM -0.820043943522528 0.244481289023155 no 2557 0.206095528309844 3834 7292267
SGTC_2936 9038235 15.59 µM -0.82027670740342 0.244411984728645 no 2558 0.206029190863499 3820 4749415
SGTC_2350 9023895 38.85 µM -0.821669645274585 0.24399746569175 no 2559 0.205632469835133 3895 2997209
SGTC_3100 9120536 49.47 µM -0.821790519889241 0.243961512970443 no 2560 0.205598065070275 3693 16421196
SGTC_2072 5231554 129 µM -0.821973520637895 0.243907087006557 no 2561 0.2055459837326 3910 789545
SGTC_1626 st003712 1.76 µM -0.82217306977167 0.243847746881562 no 2562 0.205489201713782 3839 24207035
SGTC_275 trichlorophene 5.69 µM -0.824950803421223 0.243022539110454 no 2563 0.204699760893919 3901 62616
SGTC_1115 galangin 695.678 nM -0.826771147214404 0.242482572621932 no 2564 0.204183393297915 3902 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1755 st041960 45.185 µM -0.827776305028941 0.242184692538505 no 2565 0.203898598081786 3932 2257073
SGTC_1180 1193-0155 285 µM -0.829279591177298 0.241739561795289 no 2566 0.203473108308429 3907 2921347
SGTC_2328 6201408 200 µM -0.829281152896762 0.241739099593149 no 2567 0.203472666555292 3886 2890418
SGTC_85 0868-0259 160.055 µM -0.830182504852426 0.241472418021731 no 2568 0.203217802621066 3836 83173
SGTC_586 0957-0265 8.15 µM -0.832354045908708 0.240830584357835 no 2569 0.202604566352322 3734 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2114 5491910 81.25 µM -0.832370782455668 0.240825641210949 no 2570 0.202599844304143 3951 2849228
SGTC_2923 7992654 58.14 µM -0.832491117617015 0.240790101790757 no 2571 0.202565894887056 3897 2985126
SGTC_2128 5255449 168.493 µM -0.833130852343502 0.240601212406987 no 2572 0.202385467574926 3876 736008
SGTC_154 3389-1638 511.116 µM -0.833891142409678 0.240376832549718 no 2573 0.202171164512113 3872 5238686
SGTC_3056 9094900 49.47 µM -0.834234532962197 0.240275527131019 no 2574 0.202074417495713 3865 25236784
SGTC_471 1-acyl-paf 4 µM -0.83689600303257 0.239491142557709 no 2575 0.201325513629083 3822 16759367
SGTC_3288 9119690 36.221 µM -0.840547360735421 0.238417298510511 no 2576 0.200300779344898 3895 17595618 YKL019W RAM2
SGTC_1384 3089-0840 101 µM -0.840765491577701 0.238353231003904 no 2577 0.200239661436106 3849 1069836
SGTC_923 1900-2434 73.3 µM -0.840812301925485 0.238339483501835 no 2578 0.200226547142278 3851 5910570
SGTC_2312 7706453 155.7 µM -0.84137623656014 0.238173898431789 no 2579 0.20006859690542 3918 976098
SGTC_716 1683-5115 658 µM -0.842115575579073 0.237956905846676 no 2580 0.199861631854195 3870 723597
SGTC_2909 7941780 10.49 µM -0.842974488750889 0.237704954954419 no 2581 0.199621355862364 3839 1243215
SGTC_302 1094-0063 18.9 µM -0.844081175725528 0.23738053875269 no 2582 0.199312022983835 3849 5440289
SGTC_1725 st036284 20.55 µM -0.845859179707443 0.236859840901152 no 2583 0.198815653396938 4003 707914
SGTC_3234 9132280 49.47 µM -0.846260042474969 0.236742532935339 no 2584 0.198703846620028 3947 17612295
SGTC_1652 st011932 78 µM -0.847155224524069 0.23648068339981 no 2585 0.198454303518114 3815 1551076
SGTC_1177 0983-0204 23.6 µM -0.847648496159915 0.236336464748039 no 2586 0.198316878765268 3944 766818
SGTC_3220 9131269 49.47 µM -0.848705380623009 0.236027624765493 no 2587 0.198022625728109 3926 17722206
SGTC_990 3985-0011 41.3 µM -0.849719370451421 0.235731528488411 no 2588 0.197740563199669 3911 5399565 YGL099W LSG1
SGTC_693 4161-2696 114 µM -0.850024172892386 0.235642562852059 no 2589 0.19765582349299 3937 805759
SGTC_1374 2889-5571 141 µM -0.852802469222832 0.234832488965915 no 2590 0.196884427196504 3935 2853281
SGTC_1123 mangostin 811.285 nM -0.853143985056012 0.234733018797864 no 2591 0.196789730999225 3932 5281650 An antioxidant.
SGTC_2493 resveratrol 26.09 µM -0.853230722436646 0.234707759310684 no 2592 0.196765684676672 3783 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1751 st044839 27.194 µM -0.853910183375738 0.234509940057792 no 2593 0.196577378365874 3854 5291326
SGTC_1572 epiandrosterone 68.9 µM -0.854246261179505 0.234412127977475 no 2594 0.1964842778847 3824 441302 A steroid.
SGTC_3184 9108758 49.47 µM -0.854792012766224 0.234253340546097 no 2595 0.196333150379084 3922 902885
SGTC_790 1575-0012 79.1 µM -0.854989693811326 0.234195839574149 no 2596 0.196278426665876 3997 378741 YLR208W SEC13
SGTC_1476 4112-3294 3.34 µM -0.856489520789559 0.233759828281569 no 2597 0.195863533383382 3952 704369
SGTC_2352 9027995 87.8 µM -0.856952128308578 0.233625435546798 no 2598 0.195735670919884 3869 2997347
SGTC_2068 5226020 147 µM -0.858007929550689 0.233318873825815 no 2599 0.195444042434069 3950 1810509
SGTC_701 4424-0219 185 µM -0.858086254668501 0.233296140296146 no 2600 0.195422418356382 3955 2911779
SGTC_1210 3013-0140 750 nM -0.862258118582564 0.232087052612723 no 2601 0.194272747027466 3953 905973
SGTC_2971 9092186 9.93 µM -0.862633469203749 0.231978439971406 no 2602 0.194169511229692 3953 25236400
SGTC_2294 7971431 200 µM -0.86367982718192 0.231675811994652 no 2603 0.193881899164309 3905 5741572
SGTC_349 k015-0014 24 µM -0.864075802929836 0.231561345173659 no 2604 0.193773125201626 3917 2196908
SGTC_209 4077-0173 175.592 µM -0.864325378883641 0.231489215121606 no 2605 0.193704586167213 3885 15993494
SGTC_1307 1187-1599 12.2 µM -0.864714210237196 0.231376863772074 no 2606 0.193597834001586 3918 1538471
SGTC_2610 ononetin 44.17 µM -0.866172015722131 0.230955907237157 no 2607 0.193197918593451 3920 259632
SGTC_3210 9128157 49.47 µM -0.866538518020228 0.230850143176119 no 2608 0.193097456494362 3990 17590849
SGTC_3192 9110362 49.47 µM -0.866572725241039 0.230840273145939 no 2609 0.193088081566279 3942 16649480
SGTC_2940 9060638 45.86 µM -0.866652425427269 0.230817277651063 no 2610 0.193066239784927 3936 4027022
SGTC_552 k242-0005 476 µM -0.870480529254293 0.229714281663789 no 2611 0.192018927608391 4011 4088318
SGTC_532 1548-0774 215 µM -0.871122911065127 0.229529481119339 no 2612 0.191843522800151 4081 5932993
SGTC_1813 st051246 8.6015 µM -0.871922995318439 0.229299429231482 no 2613 0.191625193959372 3851 5291959
SGTC_725 1497-0963 19 µM -0.87200544366903 0.229275729829016 no 2614 0.191602703915638 4005 3549977
SGTC_1810 st050138 53 µM -0.872067640990343 0.229257852401416 no 2615 0.191585738964225 3885 3444541
SGTC_174 3553-0389 74.3 µM -0.875585763620481 0.228247908836157 no 2616 0.190627633773243 3985 738071
SGTC_1881 5652484 16 µM -0.876734814621895 0.22791859465734 no 2617 0.190315346131295 3900 2255129
SGTC_1640 st009078 66.4 µM -0.876817095313204 0.227895023546476 no 2618 0.1902929960514 3908 690618
SGTC_3014 9081533 49.47 µM -0.879045178327641 0.227257261898029 no 2619 0.189688390213047 3990 21367265
SGTC_2088 5278280 127.392 µM -0.879917563570662 0.227007826502522 no 2620 0.189451984645298 4003 791502
SGTC_2374 9071832 200 µM -0.882597250512063 0.22624260737225 no 2621 0.188726957319429 3857 17381698
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.88417296569407 0.225793322884799 no 2622 0.188301424808515 3933 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2104 5389443 200 µM -0.884326847945836 0.225749473422627 no 2623 0.18825989961861 4014 2244536
SGTC_603 3794-0023 45.9 µM -0.884543705904524 0.22568768691858 no 2624 0.188201390000211 3954 3802260
SGTC_1940 st075990 51.1 µM -0.885398037282813 0.225444366555794 no 2625 0.187970995308819 4058 1084979
SGTC_3037 9091026 49.47 µM -0.885695016821831 0.225359819220752 no 2626 0.18789094715435 3923 25236398 YIL048W NEO1
SGTC_2925 9010536 32.5 µM -0.886421853774128 0.225152971203146 no 2627 0.187695123630646 3912 2994177
SGTC_1513 0337-0559 19 µM -0.886478414395481 0.225136879323061 no 2628 0.187679890426115 3928 775073
SGTC_2356 9061756 188.97 µM -0.887243670391406 0.224919222861179 no 2629 0.187473862727227 3988 20104043
SGTC_2674 ligustilide 100 µM -0.887385518540243 0.224878891082554 no 2630 0.187435688714734 4009 5319022 A signalling regulator.
SGTC_3126 9127922 49.47 µM -0.888764895083517 0.224486905877505 no 2631 0.187064723031838 4004 45595682
SGTC_3187 9109394 49.47 µM -0.888773897130164 0.224484348989253 no 2632 0.187062303539105 3961 17098090
SGTC_170 4197-0004 226 µM -0.889537973479675 0.224267385486085 no 2633 0.186857012219596 4001 218692
SGTC_3235 9132602 49.47 µM -0.889601044342036 0.224249481503499 no 2634 0.186840072630969 3982 4912240
SGTC_350 k064-0020 19.8 µM -0.890056621022241 0.224120180645422 no 2635 0.186717741955258 3946 2790705
SGTC_1745 st081495 74 µM -0.890655224256488 0.223950350667461 no 2636 0.186557081425579 3872 13842402 YBL026W LSM2
SGTC_1305 1181-0477 144 µM -0.89122039208101 0.223790073795781 no 2637 0.18640547329605 4011 6252086
SGTC_3139 9095020 49.47 µM -0.891569319984481 0.223691153321752 no 2638 0.18631191035355 3661 25236292
SGTC_3335 9143315 29.6265 µM -0.893079136320571 0.223263409563727 no 2639 0.185907397515507 3961 4899691
SGTC_1788 fluconazole 20 µM -0.893130957007336 0.223248736592442 no 2640 0.185893523293555 4017 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1184 1269-1718 139 µM -0.8943717449707 0.222897572774381 no 2641 0.185561512451126 4028 5403821
SGTC_2431 5490079 200 µM -0.894611989172345 0.222829616014422 no 2642 0.185497270301656 4020 5722345
SGTC_2414 st077232 92.9 µM -0.895297655445339 0.222635729723608 no 2643 0.185313996645856 3935 729801
SGTC_4 0960-0234 25.671 µM -0.895345573062394 0.222622183624544 no 2644 0.185301192816492 3960 6821112
SGTC_332 4112-0506 40.9 µM -0.895586265288499 0.222554148101396 no 2645 0.18523688694717 3937 2790355
SGTC_2560 caryophyllene 100 µM -0.895862532698083 0.222476071296276 no 2646 0.185163093521937 4012 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2225 6654152 15.4 µM -0.896434818490988 0.222314385504251 no 2647 0.185010289110913 3838 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2715 st079500 56.4 µM -0.898349412573031 0.221773949870454 no 2648 0.184499648496538 3913 28246688
SGTC_1461 k072-0203 53.8 µM -0.898615299722168 0.221698956861211 no 2649 0.18442880322949 3885 5418714
SGTC_3268 9137683 49.47 µM -0.899876356549708 0.221343475356207 no 2650 0.184093026875637 4002 1953228
SGTC_2727 riluzole 51.77 µM -0.901509450000489 0.220883604555433 no 2651 0.183658755811626 3982 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1955 wogonin 32.4 µM -0.901514851275459 0.220882084492025 no 2652 0.183657320568273 4053 5281703 A flavanone.
SGTC_2120 5538279 151.968 µM -0.901719775153555 0.2208244178495 no 2653 0.183602872729287 3958 2058197
SGTC_254 nsc-64875 3.808 µM -0.901972728012875 0.22075324749186 no 2654 0.183535677565323 4001 56993
SGTC_2712 st079126 47.7 µM -0.902235550268107 0.220679314215918 no 2655 0.183465876903222 3965 3152970
SGTC_10 0279-0212 42.575 µM -0.902292012125507 0.220663433050889 no 2656 0.18345088385231 3937 39851 YBR002C RER2
SGTC_2143 5623677 140.463 µM -0.903718613716945 0.220262386621862 no 2657 0.18307231326832 3901 5375313
SGTC_44 0929-0055 61.211 µM -0.903806086114062 0.220237809975752 no 2658 0.183049116996781 3889 1379590
SGTC_2173 5763948 167 µM -0.903855826084785 0.22022383550664 no 2659 0.183035927575134 3969 2867177
SGTC_936 3005-4620 401 µM -0.903995425466744 0.220184617708183 no 2660 0.182998913529169 3986 777207
SGTC_1235 benzylparaben 21.5 µM -0.904463136895698 0.22005325224646 no 2661 0.182874936330177 3989 7180
SGTC_2285 7945142 200 µM -0.905255879011254 0.219830698583361 no 2662 0.182664922357479 4033 2970608
SGTC_2441 5730946 39.09 µM -0.906001677765528 0.219621441748913 no 2663 0.182467482204026 4045 1774275
SGTC_890 0929-0006 47.2 µM -0.906477265878922 0.219488060593545 no 2664 0.182341646307871 3949 1378169
SGTC_1328 1441-0025 69.2 µM -0.907415874391134 0.219224959554708 no 2665 0.182093458960948 3931 4562601
SGTC_1895 st058434 18.3 µM -0.908247529046009 0.218991990270244 no 2666 0.181873728956801 3992 5393175
SGTC_1349 flufenamic acid 69 µM -0.911195873857861 0.218167226130963 no 2667 0.181096088850815 3914 3371 A non-steroidal anti-inflammatory.
SGTC_3319 9138450 16.7555 µM -0.913045440306123 0.217650747106502 no 2668 0.180609321672924 3929 2029690
SGTC_2639 lactacystin 53 µM -0.913173430791842 0.21761503274123 no 2669 0.180575667637348 4036 3870 A proteasome inhibitor.
SGTC_3063 1327-0034 4 µM -0.916969948714215 0.216557194287043 no 2670 0.179579193824849 3901 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_322 k048-0136 19.3 µM -0.918616967306937 0.216099205987704 no 2671 0.179147976993684 4064 6823282
SGTC_173 1273-0061 2.693 µM -0.918659532280527 0.216087377339011 no 2672 0.179136841417456 3990 2847414 YPL266W DIM1
SGTC_2627 acetyl isogambogic acid 100 µM -0.919548504777807 0.215840420887046 no 2673 0.178904373631224 4021 6857789 A caspase activator and apoptosis inducer.
SGTC_1882 5615643 20 µM -0.92000901517392 0.21571255549387 no 2674 0.178784024082691 3941 2253075
SGTC_1079 idarubicin 2.36 µM -0.922677657597814 0.214972444865537 no 2675 0.17808760624841 4002 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1832 st054113 55 µM -0.923129984046918 0.214847144778189 no 2676 0.17796973535687 4013 1251267
SGTC_2771 fluoxetine 41.05 µM -0.924315141079075 0.214519042730524 no 2677 0.177661130915046 3988 3386 A selective serotonin reuptake inhibitor.
SGTC_2224 6650123 117.647 µM -0.924657421567338 0.214424339124311 no 2678 0.177572066972623 3963 2908370
SGTC_3257 9139206 32.98 µM -0.924817304808793 0.214380110287925 no 2679 0.177530473814767 4001 4910041
SGTC_2112 5488546 200 µM -0.926411392548562 0.213939424697183 no 2680 0.177116112890409 3971 600757
SGTC_1395 3486-0190 4.35 µM -0.927333240462164 0.21368482067844 no 2681 0.176876770392082 3971 6748079
SGTC_319 1348-1596 45.5 µM -0.928762628666232 0.213290388964772 no 2682 0.176506057913076 4107 5380505
SGTC_846 0335-0850 148 µM -0.933088292473716 0.212099335415541 no 2683 0.175387191696057 3997 6819598
SGTC_1280 0880-0253 10.1 µM -0.934650907494797 0.21167003389176 no 2684 0.174984117267439 4001 6836607
SGTC_2497 7-hydroxyflavone 100 µM -0.935885714692294 0.211331151941534 no 2685 0.174666016512046 4057 5281894
SGTC_983 1491-0821 12.2 µM -0.936024280854923 0.211293143522622 no 2686 0.174630343176443 4028 46495113
SGTC_1495 4469-0029 237 µM -0.937570178252152 0.210869378616518 no 2687 0.17423267147653 4022 793680
SGTC_3042 9091578 49.47 µM -0.940518175560825 0.210062649728493 no 2688 0.173475915548598 3987 25236497
SGTC_1649 st011737 51.3 µM -0.940659740815823 0.210023955626593 no 2689 0.173439628225679 4007 1761035
SGTC_714 4296-0578 26.1 µM -0.94072999705737 0.21000475400802 no 2690 0.173421621286375 4045 1589775
SGTC_1193 1488-0126 41.5 µM -0.941367614972147 0.209830534866388 no 2691 0.173258251826402 4000 1384710
SGTC_1865 st057639 52.2 µM -0.943490207169451 0.209251182194661 no 2692 0.172715110978389 4003 688818
SGTC_1054 3429-0080 167 µM -0.94358795546143 0.209224524905569 no 2693 0.17269012476538 4075 1162877
SGTC_2353 9059630 146.67 µM -0.94518501300369 0.208789268815264 no 2694 0.172282214701459 4069 4779114
SGTC_2582 agaric acid 100 µM -0.946575333710161 0.208410790802334 no 2695 0.1719276089792 3801 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1386 3228-0095 33.8 µM -0.94763325704202 0.208123070458441 no 2696 0.171658094710653 4061 870181
SGTC_1494 4358-1428 177 µM -0.949428104105247 0.207635467700753 no 2697 0.171201461108683 4062 1564571
SGTC_1515 3460-0031 42.1 µM -0.950839472691169 0.207252518321158 no 2698 0.170842935714624 3965 2876596
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.950910312674869 0.20723330818546 no 2699 0.170824953134493 4026 689007
SGTC_1426 4048-4480 71.7 µM -0.951106684459685 0.207180062286567 no 2700 0.170775110904913 4017 14224343
SGTC_1488 4013-0813 75.9 µM -0.952459013805459 0.206813600118724 no 2701 0.170432121351714 3969 2910057
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.952862154820323 0.206704428882728 no 2702 0.170329958636924 4039 77254
SGTC_2687 chenodiol 100 µM -0.953596240491126 0.206505724962779 no 2703 0.170144029753646 4122 5702181 A cholesterol synthesis inhibitor.
SGTC_2506 ethyl hematommate 54.16 µM -0.953638363629298 0.20649432641317 no 2704 0.170133364771505 4107 3940691 An allergen.
SGTC_3099 9120367 49.47 µM -0.954581978133834 0.206239081400263 no 2705 0.169894567233099 4053 24824940
SGTC_1332 1480-0653 17.5 µM -0.957148661497105 0.205545747789464 no 2706 0.169246112620769 4042 5749438
SGTC_969 1313-0238 134 µM -0.957469347215068 0.205459218883147 no 2707 0.169165205424457 4059 5212874
SGTC_1472 k841-0093 193 µM -0.958853563106619 0.205085971603002 no 2708 0.168816260573968 4141 X1472
SGTC_987 1497-1013 404 µM -0.961481165714604 0.204378560514265 no 2709 0.16815514550091 3999 1676435
SGTC_380 3970-0968 6 µM -0.961687907944297 0.204322962458005 no 2710 0.168103199132687 3937 2891601
SGTC_3019 9081971 49.47 µM -0.964401533426554 0.203594037132786 no 2711 0.167422326871202 4094 16451803
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.96534967503545 0.203339716432065 no 2712 0.167184849375045 4087 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_213 1246-0773 967 nM -0.968152492987744 0.202589023839423 no 2713 0.166484108465303 4039 6251622
SGTC_315 k915-0449 187 µM -0.968515559799971 0.202491903196096 no 2714 0.166393475958252 4067 20970215 YNL149C PGA2
SGTC_1922 5578187 25 µM -0.968581286026201 0.202474324357697 no 2715 0.166377072101575 4086 1350412
SGTC_1029 k015-0030 64.7 µM -0.968888865081195 0.202392072784915 no 2716 0.166300320842834 4118 2208316
SGTC_1956 st077085 54 µM -0.970306674299947 0.202013186266465 no 2717 0.165946825715974 4103 24208685
SGTC_2239 6685329 187.64 µM -0.970813470775993 0.201877856187509 no 2718 0.165820586640432 4112 805680
SGTC_1311 1190-0148 100 µM -0.971123645870897 0.201795056781474 no 2719 0.165743355059236 4124 1961333
SGTC_597 k018-0003 82.8 µM -0.972227574170844 0.201500534676781 no 2720 0.165468672803092 4121 6786234
SGTC_1548 st061468 90.8 µM -0.972443897590965 0.201442850954151 no 2721 0.165414881183883 4042 390799
SGTC_2780 5215298 71.43 µM -0.97248758099477 0.201431203756973 no 2722 0.165404020113039 4094 2834131
SGTC_1569 carminic acid 40.6 µM -0.975219557409365 0.200703585843868 no 2723 0.164725681460162 4162 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_180 1486-1293 102.781 µM -0.977867387282281 0.199999886778998 no 2724 0.164069958394266 3946 4140536
SGTC_2038 4100038 30.985 µM -0.978057289179827 0.199949474679849 no 2725 0.164022995213377 4057 3596803
SGTC_1477 0139-0234 16 µM -0.980156170212545 0.199392806593125 no 2726 0.163504517986639 4084 620880
SGTC_455 paf C-16 10 µM -0.980666801460404 0.199257517525562 no 2727 0.163378540170779 4031 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3089 9117425 49.47 µM -0.981028558948368 0.199161705243148 no 2728 0.163289329162312 4072 9401657
SGTC_1748 st037455 53.6035 µM -0.982287494303668 0.19882848978941 no 2729 0.162979116859632 4118 580690
SGTC_1996 st072960 66.8 µM -0.982924644129389 0.198659976910252 no 2730 0.162822263876148 4112 1719405
SGTC_1411 3909-8223 150 µM -0.983190577678143 0.198589668500252 no 2731 0.162756825636324 4091 X1411
SGTC_805 3852-0218 479 µM -0.985254514827978 0.198044508237301 no 2732 0.162249534472467 4021 6615355
SGTC_191 3914-0123 66.505 µM -0.985274164568691 0.19803932237866 no 2733 0.162244709752475 4044 3144412
SGTC_1143 3454-2408 5.08 µM -0.986972172169271 0.197591502710581 no 2734 0.161828140443884 4038 X1143
SGTC_3092 9117248 49.47 µM -0.987601643488091 0.197425646357455 no 2735 0.161673890540289 4167 17141857
SGTC_2998 9066762 71.4286 µM -0.989784398487545 0.196851175230329 no 2736 0.161139756063428 4129 4945196
SGTC_1540 guanosine 70.6 µM -0.989849516273895 0.196834052686038 no 2737 0.161123839020938 3951 6802 Guanosine is a purine nucleoside
SGTC_2880 9042983 58.44 µM -0.992402291168132 0.196163518345564 no 2738 0.160500660876649 4088 6464714
SGTC_1621 st003705 32.4 µM -0.995658058955207 0.19531034245351 no 2739 0.159708157415451 4092 24207032
SGTC_908 3448-7491 47.7 µM -0.999860967217121 0.194212307527723 no 2740 0.158688898133323 4094 1203031
SGTC_778 3456-2434 196 µM -1.00058064984264 0.194024663856497 no 2741 0.158514794459068 4060 5539063
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.00296693585247 0.193403275560201 no 2742 0.15793840731093 4141 61125 An anti-inflammatory.
SGTC_2621 lithochol-11-enic acid 100 µM -1.0034807378386 0.193269640680495 no 2743 0.157814483074331 4020 6708711
SGTC_296 1222-0039 74.9 µM -1.00533214135766 0.192788576263249 no 2744 0.157368471630953 4092 5984176
SGTC_2276 7947513 42.08 µM -1.00769005580187 0.192176961428946 no 2745 0.156801640193391 4053 2105100
SGTC_3351 9150312 21.596 µM -1.00783857062657 0.192138478236339 no 2746 0.156765982968283 4020 4904905
SGTC_2709 st078560 56 µM -1.00878558037274 0.191893199771887 no 2747 0.15653873899071 4101 17250903
SGTC_2694 st077685 81.9 µM -1.00880374911609 0.191888495885644 no 2748 0.156534381349742 4046 2838096
SGTC_358 0075-0058 9.45 µM -1.01076293350357 0.191381677455818 no 2749 0.15606495387725 3925 1069125
SGTC_346 4513-0042 7.16 µM -1.01112483826191 0.191288146707084 no 2750 0.155978341842491 4086 2827372
SGTC_2792 7535235 81.82 µM -1.01171036186942 0.191136883198482 no 2751 0.155838279841509 4112 1281891
SGTC_2273 7815444 169.05 µM -1.0121796060406 0.191015712144327 no 2752 0.155726092698612 4070 2824616
SGTC_1283 0922-0125 16.4 µM -1.01269861969496 0.190881744201321 no 2753 0.155602068688075 4102 3360884
SGTC_601 0986-0029 62.9 µM -1.01306938051996 0.190786078623639 no 2754 0.155513511224584 4045 24747981
SGTC_1864 st057645 30.4 µM -1.01329005664291 0.190729152626839 no 2755 0.155460817782174 4144 688666
SGTC_3345 9148410 3.559 µM -1.01395222031598 0.190558402308295 no 2756 0.155302775860201 4070 4903596
SGTC_1294 1000-1494 117 µM -1.0139677248047 0.190554405333352 no 2757 0.155299076597127 4107 712797 YDL207W GLE1
SGTC_843 0310-0051 143 µM -1.01399676744371 0.190546918433591 no 2758 0.155292147382135 4129 2065037
SGTC_325 2810-4341 181 µM -1.01417416209715 0.190501191799588 no 2759 0.155249827638368 4099 774970
SGTC_1578 josamycin 24.2 µM -1.01467415408772 0.190372346213212 no 2760 0.155130589177572 4115 5282165 A P450 substrate.
SGTC_2468 5987765 72.9 µM -1.01478320102127 0.190344252441938 no 2761 0.155104591617379 4146 26772094
SGTC_2001 4023502 57.655 µM -1.0155105409392 0.19015693293682 no 2762 0.154931262220319 4142 108941 YCR052W RSC6
SGTC_3343 9148379 18.9835 µM -1.020247331435 0.188939790288387 no 2763 0.153805587584812 4151 1955036
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.0218284802876 0.188534576799371 no 2764 0.153431043597442 4159 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1321 1326-2144 215 µM -1.02191405486697 0.18851266122377 no 2765 0.153410789861003 4124 3513030
SGTC_1965 Pectolinarigenin 58.4 µM -1.02201214202552 0.188487543119837 no 2766 0.153387576833859 4082 5320438 An anti-inflammatory.
SGTC_2887 9044784 58.44 µM -1.02307744482192 0.188214873936296 no 2767 0.153135615183384 4083 6465546
SGTC_565 1418-0001 44.5 µM -1.02713812990585 0.187177756618172 no 2768 0.152177713168221 4195 2862145
SGTC_2850 9015429 58.44 µM -1.02774000027809 0.18702433749986 no 2769 0.152036073250689 4151 6457570
SGTC_1121 fusaric acid 630.51 nM -1.02876694546098 0.186762744812589 no 2770 0.151794601449835 4079 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_327 1273-0057 3.96 µM -1.0298307313746 0.186492006664133 no 2771 0.151544735927901 3987 3108138
SGTC_592 k241-0073 46.5 µM -1.03136185410175 0.186102756218332 no 2772 0.151185581065367 4152 4230158
SGTC_3061 glucosamine 200 µM -1.03337207893794 0.185592471060434 no 2773 0.150714903843739 4034 91431 and experimental redox chemotherapeutic
SGTC_886 0866-0150 153 µM -1.0341759064745 0.185388666841437 no 2774 0.150526967769558 4193 271463
SGTC_1104 tacrolimus 29.8 µM -1.03418202907834 0.185387115036212 no 2775 0.150525536894955 4168 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2979 9012552 45.46 µM -1.0350091649078 0.185177547369669 no 2776 0.150332315555319 4153 17100905
SGTC_1650 st011916 45.8 µM -1.03660503756627 0.18477362432985 no 2777 0.149959982305557 4044 242528
SGTC_768 0384-0033 77.3 µM -1.03675795991873 0.184734947723459 no 2778 0.14992433628575 4100 3965305 YMR134W ERG29
SGTC_1620 st003704 16.5 µM -1.03922488362107 0.184111717316426 no 2779 0.149350080119552 4095 2834414
SGTC_354 2783-3500 4.88 µM -1.03935880464407 0.184077921722012 no 2780 0.149318947754847 4142 6740761
SGTC_193 1273-0060 1.558 µM -1.03982608161945 0.183960032447893 no 2781 0.149210354703612 3933 2847393 YHR072W ERG7
SGTC_470 aa-861 153 µM -1.04181586547532 0.18345855654069 no 2782 0.148748528504581 4114 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_94 0334-0113 514.748 µM -1.04183531894069 0.183453657984986 no 2783 0.148744018102031 4155 6795178
SGTC_553 k007-0256 45.7 µM -1.04229056818678 0.183339045454404 no 2784 0.148638491936051 4184 6287000
SGTC_1718 roemerine 11.9335 µM -1.04233488563945 0.18332789057692 no 2785 0.148628221883701 3875 235224 An aporphine alkaloid with mutagenic activity.
SGTC_200 k038-0079 37.545 µM -1.04291157633231 0.183182773841717 no 2786 0.148494623798458 4099 3436683
SGTC_676 falcarinol 140 µM -1.04408173210617 0.182888539568585 no 2787 0.148223788468635 4152 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_978 1416-0512 87.4 µM -1.04656565602968 0.182264938134193 no 2788 0.147649974358507 4227 6814003
SGTC_1150 3909-7983 10.9 µM -1.04716419586929 0.182114870642825 no 2789 0.147511927736299 4117 23965914
SGTC_381 3461-2219 42.7 µM -1.04855572499173 0.181766281416311 no 2790 0.147191321165296 4145 2883159
SGTC_816 0325-0417 81.3 µM -1.04914080831285 0.181619838077852 no 2791 0.1470566582959 4158 68101
SGTC_47 0149-0135 24.25 µM -1.0524943117 0.180781898510397 no 2792 0.146286409473213 4172 5239155
SGTC_306 1672-3436 11.6 µM -1.05253480079128 0.180771796334991 no 2793 0.146277126326191 4198 6797378
SGTC_2096 5468907 200 µM -1.05298704540663 0.180658983713297 no 2794 0.14617346470989 4166 759785
SGTC_611 3453-1652 23.7 µM -1.05303954879799 0.180645889579468 no 2795 0.146161433299896 4171 1560575
SGTC_1741 st038134 10.228 µM -1.05619410300152 0.179860248785097 no 2796 0.145439772187581 4207 1272587
SGTC_3250 9135583 49.47 µM -1.05797605097754 0.179417405178533 no 2797 0.145033180496534 4197 7699353
SGTC_953 1188-0045 9.7 µM -1.05889682463996 0.179188846511993 no 2798 0.144823385283548 4169 6144426
SGTC_1387 3342-1166 1.8 µM -1.0592470135867 0.179101969094496 no 2799 0.144743649564101 4120 3418228
SGTC_1816 st051957 91.6 µM -1.05926827551976 0.179096695133124 no 2800 0.144738809314055 4133 674121
SGTC_1460 k062-0059 9.15 µM -1.05991960526148 0.178935182003776 no 2801 0.144590587804745 4042 1373085
SGTC_2275 7947463 200 µM -1.06072476026146 0.178735650878156 no 2802 0.1444075020387 4131 1225414
SGTC_2075 5212009 200 µM -1.06105649918418 0.178653481085261 no 2803 0.144332112743952 4067 780898
SGTC_2647 atorvastatin 60.16 µM -1.06487121547685 0.177710308194629 no 2804 0.143467106228482 4127 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1427 4048-4900 550 nM -1.06497160272239 0.177685530361276 no 2805 0.143444390267013 4153 24132586
SGTC_2906 7926292 26.41 µM -1.06637839054448 0.177338532775605 no 2806 0.143126313066298 4173 2966319
SGTC_3197 9113331 49.47 µM -1.06723160296632 0.17712828841432 no 2807 0.142933632529823 4186 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_390 dec-rvkr-cmk 16.7 µM -1.06797985280693 0.176944038055619 no 2808 0.142764799977571 4197 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1228 0124-0032 52.5 µM -1.06902840027543 0.176686045742091 no 2809 0.142528436197038 4231 X1228
SGTC_1464 k208-0027 110 µM -1.06953611428303 0.17656120956836 no 2810 0.142414082356314 4172 X1464
SGTC_1174 0739-0097 51.1 µM -1.06977317083987 0.176502941464991 no 2811 0.142360710707223 4199 728447
SGTC_2876 9059903 25.97 µM -1.07109727205806 0.176177703350226 no 2812 0.14206284734118 4149 6916095
SGTC_225 nsc-122657 1.016 µM -1.07216595601577 0.175915480019475 no 2813 0.141822749253109 4174 275685
SGTC_280 3448-3607 3.04 µM -1.07265447682889 0.175795693868055 no 2814 0.141713086287981 4138 626179
SGTC_1856 st057054 55.7 µM -1.07278303267903 0.175764180339571 no 2815 0.141684237668365 4178 1266018
SGTC_295 k015-0027 31 µM -1.07647759570211 0.174860043531632 no 2816 0.140856857766129 4197 3887424
SGTC_1128 3448-9350 235 µM -1.07665940422688 0.174815627518668 no 2817 0.140816227402039 4229 619386
SGTC_2299 7976368 114.88 µM -1.07683675600568 0.174772307193854 no 2818 0.140776600688941 4201 2979718
SGTC_2445 5742597 35.57 µM -1.08222085462512 0.173460420320986 no 2819 0.139577201980269 4164 1774255
SGTC_1185 1319-0113 81.3 µM -1.08298061899436 0.173275802427897 no 2820 0.139408512836028 4240 4672763
SGTC_1653 st012112 65 µM -1.08446852680847 0.172914612906204 no 2821 0.139078557180406 4166 720429
SGTC_1710 st031758 61.5 µM -1.0848972260588 0.172810635281577 no 2822 0.138983588360917 4210 5394341
SGTC_1466 k213-0079 57.5 µM -1.08508060643932 0.172766169986751 no 2823 0.138942977986135 4100 3657981
SGTC_1678 st019265 80.2 µM -1.08525195315094 0.17272462915588 no 2824 0.138905039821162 4185 5367020
SGTC_2480 5767542 37.17 µM -1.08561589016011 0.172636418382543 no 2825 0.138824483315687 4125 2867358
SGTC_2731 amoxapine 43.43 µM -1.08626469231343 0.172479233470938 no 2826 0.138680951584558 4309 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2220 6782180 200 µM -1.08870885682478 0.171887907120885 no 2827 0.138141147428297 4105 833803
SGTC_119 0121-0043 24.815 µM -1.09075803314308 0.171393140668215 no 2828 0.137689683622866 4190 1092378
SGTC_2818 7996756 12.99 µM -1.09235963892421 0.171007072983886 no 2829 0.13733752801027 4203 2241621
SGTC_1563 conessine 56.1 µM -1.09273590218856 0.170916455338985 no 2830 0.137254885828778 4269 441082 An anti-amoebic, histamine inhibitor.
SGTC_1529 apigenin 74 µM -1.09419367524239 0.170565661639151 no 2831 0.13693502240414 4215 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2317 5986382 200 µM -1.09614185343367 0.170097578684779 no 2832 0.136508350545743 4217 877883
SGTC_2524 avocatin b 10.57 µM -1.09858838497061 0.169510925090976 no 2833 0.135973823132609 4165 6710748
SGTC_1003 4049-0218 100 µM -1.10127977565906 0.168867058254827 no 2834 0.13538745525906 4223 295161
SGTC_765 1319-0117 244 µM -1.10219501515482 0.168648462147463 no 2835 0.135188449332684 4159 3487746 YGL099W LSG1
SGTC_482 fipronil 114 µM -1.10249902331306 0.16857589299602 no 2836 0.135122391439328 4293 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3267 9137951 49.47 µM -1.10286163558888 0.168489360833911 no 2837 0.135043628413905 4226 16643986
SGTC_1683 st010134 710 nM -1.10334310499147 0.168374509285372 no 2838 0.134939097094637 4183 3818134
SGTC_1320 1313-0481 95.3 µM -1.10641448809144 0.167643035249442 no 2839 0.134273578727584 4182 6813365 YLR208W SEC13
SGTC_1978 st071761 42 µM -1.11489428650942 0.165634148219943 no 2840 0.132447862687924 4235 5147680
SGTC_466 geldanamycin 89.2 µM -1.11752103962009 0.165015034419256 no 2841 0.131885804395467 4152 5288382 HSP90 inhibitor.
SGTC_2829 7992743 58.44 µM -1.11912409566998 0.164637938564058 no 2842 0.131543600779371 4215 16462845
SGTC_1597 7-benzyloxygramine 47.5 µM -1.11925761481616 0.164606555317588 no 2843 0.131515126184936 4132 260807
SGTC_988 1497-1057 103 µM -1.11949651455693 0.164550412374721 no 2844 0.13146418850466 4194 3533044
SGTC_2803 7707263 71.43 µM -1.12220154600156 0.163915578871062 no 2845 0.130888377732339 4191 2199229
SGTC_1226 3909-7979 35.4 µM -1.12450572805432 0.163376074323743 no 2846 0.130399270936284 4208 6615510
SGTC_1581 himbacine 57.9 µM -1.12561477184253 0.163116812869474 no 2847 0.130164306382362 4222 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_525 k781-2675 26.7 µM -1.12646966515796 0.162917146838658 no 2848 0.129983386802946 4175 3651118 YDL195W SEC31
SGTC_3255 9139072 49.47 µM -1.127755913094 0.162617034598883 no 2849 0.129711508500624 4237 17646060
SGTC_2206 7254556 146.969 µM -1.12924201326306 0.162270740198259 no 2850 0.129397877490302 4236 4398905
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.12976174584537 0.162149744337184 no 2851 0.129288315705331 4245 5377381
SGTC_457 grayanotoxin iii 135 µM -1.13165941926142 0.161708457237951 no 2852 0.12888882432262 4066 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2018 5133068 143 µM -1.13293240009168 0.161412875899305 no 2853 0.128621321260877 4176 785362
SGTC_51 1013-0126 23.419 µM -1.13541738963493 0.160836886585523 no 2854 0.128100238476139 4248 1627850
SGTC_24 0417-1663 219 µM -1.13603865018007 0.160693096140598 no 2855 0.127970194463075 4251 4329390
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.13623706029087 0.160647191911167 no 2856 0.127928682028551 4233 5024745
SGTC_1407 3909-7909 12.3 µM -1.13868444003145 0.160081669758051 no 2857 0.127417397471346 4229 4411780
SGTC_2465 5809242 33.21 µM -1.1397509620917 0.159835633552509 no 2858 0.127195034463232 4275 2731748
SGTC_462 ag-879 158 µM -1.14080207979282 0.159593393143372 no 2859 0.126976147474647 4260 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1698 5-fluorocytosine 1.055 µM -1.14099307793191 0.159549401554726 no 2860 0.126936401780594 4231 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_454 lyso-paf C-16 6.67 µM -1.14119811461141 0.159502185377779 no 2861 0.126893744380134 4256 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1047 2043-3044 82 µM -1.14182007725082 0.159359014778807 no 2862 0.126764407562728 4218 669592
SGTC_591 4299-0174 154 µM -1.14216483982844 0.159279689576499 no 2863 0.12669275391381 4245 5509088
SGTC_2974 9094440 9.66 µM -1.14332767106088 0.159012328576651 no 2864 0.126451285177155 4239 25236134
SGTC_3036 9090181 49.47 µM -1.14437058965382 0.158772788459097 no 2865 0.126234989907069 4273 25236586
SGTC_2240 6690706 185.951 µM -1.14662288292712 0.15825628363706 no 2866 0.12576875744515 4109 805876
SGTC_1657 st012939 43.4 µM -1.15042938529046 0.157385870547302 no 2867 0.124983531463787 4251 24207257
SGTC_2695 st077686 51.995 µM -1.15055491416264 0.15735722021209 no 2868 0.124957695146135 4257 2876092
SGTC_2091 4-phenylthiadiazole 200 µM -1.15239360686696 0.156937955388787 no 2869 0.12457968344985 4255 270010
SGTC_1160 4092-0570 10.5 µM -1.15258862841614 0.156893529075264 no 2870 0.124539636454819 4242 4994975
SGTC_899 1083-0020 478 µM -1.15591306841745 0.15613748759387 no 2871 0.123858358331183 4311 767123
SGTC_1754 st042065 16.137 µM -1.15707090962468 0.15587473684498 no 2872 0.123621695340884 4025 1126236 YIL048W NEO1
SGTC_1241 0364-0022 50.8 µM -1.16116860586585 0.154947182726979 no 2873 0.122786669557119 4261 4563895
SGTC_49 0717-0965 32.132 µM -1.16230031890482 0.154691652013336 no 2874 0.122556748566149 4331 5889349 YGL099W LSG1
SGTC_1801 st050089 28.441 µM -1.16398415480404 0.15431197252989 no 2875 0.122215216586272 4301 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_233 rapamycin 362 pM -1.16592352530294 0.15387543809343 no 2876 0.121822683232125 4245 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_726 3448-4391 34.2 µM -1.1666233457773 0.153718115815421 no 2877 0.121681255558228 4363 1356692
SGTC_3147 9097027 49.47 µM -1.16668775869938 0.153703640901389 no 2878 0.121668244063917 4241 25236841
SGTC_2617 dihydrotanshinone i 20.83 µM -1.16786416862788 0.153439436033096 no 2879 0.121430779704548 4220 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2046 4110841 106 µM -1.16932942743105 0.153110780751474 no 2880 0.121135465637339 4241 44119630 YMR134W ERG29
SGTC_2036 5160441 105 µM -1.16970670097268 0.153026234469023 no 2881 0.121059510283614 4224 134534 YIL048W NEO1
SGTC_1558 st069300 45.6 µM -1.17098842271545 0.152739234276311 no 2882 0.120801715372938 4201 24208000
SGTC_2483 5729050 27.16 µM -1.17143580898702 0.152639140680628 no 2883 0.120711822835952 4286 2865180
SGTC_172 1112-0046 2.638 µM -1.17356065298495 0.152164344216485 no 2884 0.12028552461421 4244 2802135 YIL048W NEO1
SGTC_1372 2752-0194 270 µM -1.17461685411891 0.151928701310072 no 2885 0.120074018649998 4197 823334
SGTC_1072 oxiconazole 14.9 nM -1.17594614248787 0.151632476213595 no 2886 0.119808199228464 4247 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1394 3474-0001 65.7 µM -1.17750880234939 0.15128473671447 no 2887 0.119496243144459 4245 5017666 YIL048W NEO1
SGTC_181 1447-1644 8.07 µM -1.17892128194863 0.150970873669179 no 2888 0.119214761236272 4244 534600
SGTC_36 0335-0881 14.2 µM -1.18029436009954 0.150666181599059 no 2889 0.118941580253579 4158 23828853
SGTC_2770 toltrazuril 17.5 µM -1.18156427984341 0.150384745587592 no 2890 0.118689316937368 4212 68591 Kills coccidiodes.
SGTC_859 0439-0102 54.6 µM -1.18456924140063 0.149720190380763 no 2891 0.118093902205513 4281 610143
SGTC_733 4069-0007 56.1 µM -1.18532070789719 0.149554308273212 no 2892 0.117945334496698 4289 5717425 YNL287W SEC21
SGTC_3186 9110464 49.47 µM -1.18708325350601 0.149165717366433 no 2893 0.11759739160511 4274 17018021
SGTC_1049 3226-0134 66 µM -1.18763368984813 0.1490445001913 no 2894 0.117488879393633 4296 5702385
SGTC_2041 5107442 45.335 µM -1.19187577519439 0.14811251556439 no 2895 0.116654979076963 4313 793005
SGTC_827 3253-0474 693 µM -1.19209759422205 0.14806388953196 no 2896 0.11661149011325 4306 5402065
SGTC_106 0092-0003 11.579 µM -1.19222521944133 0.148035917026813 no 2897 0.116586473627145 4203 1072148
SGTC_3333 9141820 12.094 µM -1.19305191063161 0.147854811040333 no 2898 0.116424521736286 4252 1939433
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.19306947873595 0.147850963947715 no 2899 0.116421081811658 4301 551469
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.19568770815492 0.14727836894229 no 2900 0.115909224933862 4155 4000243
SGTC_208 k072-0098 12.366 µM -1.19652463683444 0.14709565030722 no 2901 0.11574594512488 4250 5948901
SGTC_3103 9120822 49.47 µM -1.19659138345507 0.147081084702777 no 2902 0.115732930293274 4286 17141819
SGTC_1212 0520-0165 585 µM -1.20042545666004 0.146246027353973 no 2903 0.114987073560395 4405 5403258
SGTC_3229 9132204 49.47 µM -1.2019472757584 0.145915461072081 no 2904 0.114691978117322 4344 17682924
SGTC_803 4488-1585 147 µM -1.20232531781804 0.145833421504899 no 2905 0.114618755738947 4271 747204
SGTC_3280 9140961 49.47 µM -1.20242720816982 0.145811315406551 no 2906 0.114599026448019 4326 4901226
SGTC_3018 9082602 49.47 µM -1.20243976962681 0.145808590232791 no 2907 0.114596594308147 4221 17332089
SGTC_11 0438-0307 1.3 µM -1.20322574668474 0.145638142740811 no 2908 0.114444487074007 4286 4011476
SGTC_2892 9047358 58.44 µM -1.20358011234133 0.145561338608679 no 2909 0.11437595502723 4295 6466771
SGTC_977 1348-1378 135 µM -1.2043993124414 0.145383891951472 no 2910 0.114217638836247 4276 X977
SGTC_2733 amorolfine 100 µM -1.20522832089884 0.145204468901197 no 2911 0.11405758605072 4434 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2371 9071574 200 µM -1.2054534472884 0.145155770329467 no 2912 0.114014149549906 4286 45596039
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.20790086491903 0.144627062563704 no 2913 0.113542698433265 4347 1273210
SGTC_617 3770-0098 35 µM -1.20937154289518 0.144309981465529 no 2914 0.113260068169965 4207 5962639
SGTC_3324 9138759 60.749 µM -1.21001299621231 0.144171829719102 no 2915 0.113136953008278 4329 45595710
SGTC_1957 st077035 62.4 µM -1.21394541405569 0.143326842251514 no 2916 0.112384284641299 4300 705593
SGTC_3067 9117431 49.47 µM -1.2141961844573 0.143273071042987 no 2917 0.112336408595046 4316 17150885
SGTC_2264 7948757 110.76 µM -1.21478570697605 0.143146716895071 no 2918 0.112223916802475 4261 2971411
SGTC_925 2064-1272 59.6 µM -1.21700684888068 0.142671329058599 no 2919 0.111800805022299 4274 6815817
SGTC_3193 9111931 49.47 µM -1.21859887853875 0.14233124668555 no 2920 0.11149823745786 4310 17087244
SGTC_3055 9094636 49.47 µM -1.21947754545107 0.14214378479257 no 2921 0.111331496695051 4339 25236176
SGTC_2334 9017922 200 µM -1.21976666558588 0.142082138123278 no 2922 0.111276670684772 4349 3163164
SGTC_426 0988-0037 14.6 µM -1.22276891449436 0.141443063340267 no 2923 0.110708494777394 4348 5383008
SGTC_1211 1056-0033 32.3 µM -1.22413738651302 0.141152410376254 no 2924 0.110450202246994 4363 6741922
SGTC_266 formosanin C 406 nM -1.22740886595026 0.140459215466689 no 2925 0.109834477883668 4156 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_83 0170-0301 39.027 µM -1.22954001452218 0.14000889091751 no 2926 0.109434702364697 4313 3089716
SGTC_294 k038-0071 157 µM -1.22986139651939 0.139941066185998 no 2927 0.109374506118521 4319 24152826
SGTC_3109 9122853 49.47 µM -1.2306684532929 0.139770842688736 no 2928 0.109223445741439 4338 1234709
SGTC_1310 1188-0297 994 nM -1.23222879620536 0.139442136223774 no 2929 0.108931814668894 4191 1588352
SGTC_2343 7990716 14.84 µM -1.23556178628754 0.138741761069492 no 2930 0.108310748259026 4320 6456862
SGTC_758 0868-0029 16 µM -1.23698806911596 0.138442783580588 no 2931 0.10804575600874 4313 762687
SGTC_2645 abamectin 100 µM -1.24045943002797 0.137716952520076 no 2932 0.107402755535018 4271 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1655 st012546 55.1 µM -1.24105160679462 0.137593393320299 no 2933 0.107293342555131 4316 720985 YLR208W SEC13
SGTC_981 1488-1094 54.9 µM -1.24119243021499 0.137564021292981 no 2934 0.107267335280236 4287 3449522
SGTC_1333 1482-0047 286 µM -1.24400090737296 0.136979141263403 no 2935 0.10674961448909 4325 3811116
SGTC_2381 9035592 200 µM -1.24404274062622 0.136970442133821 no 2936 0.106741916509732 4329 4749657
SGTC_2386 9075165 157.42 µM -1.24605141290259 0.136553187543952 no 2937 0.106372760379626 4301 16452277
SGTC_382 3229-0966 23.2 µM -1.24635564317846 0.136490066715739 no 2938 0.106316929073523 4366 5722370
SGTC_2749 bexarotene 57.39 µM -1.24819350679318 0.136109176472602 no 2939 0.105980100637307 4347 82146 An retinoic acid receptor inhibitor.
SGTC_891 0929-0073 133 µM -1.24907383697752 0.135926989331954 no 2940 0.105819034429649 4364 5603632
SGTC_114 0364-0001 490.298 µM -1.25045082755994 0.135642351713166 no 2941 0.10556745362542 4363 4003655
SGTC_2875 9039966 71.43 µM -1.25091909290591 0.135545649722772 no 2942 0.105481998605827 4336 6463691
SGTC_557 1315-0110 16.2 µM -1.25379208775503 0.134953378448439 no 2943 0.104958792920737 4317 6833801
SGTC_3290 9121031 71.43 µM -1.25528320336832 0.134646683971322 no 2944 0.104687985208409 4338 17014854
SGTC_1829 berberine 14.4 µM -1.25556748081995 0.134588267773049 no 2945 0.104636413884616 4283 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2182 6325192 200 µM -1.25579206870823 0.134542129490282 no 2946 0.10459568397369 4329 736248
SGTC_1934 st074720 32.6 µM -1.2583734500706 0.134012602138447 no 2947 0.104128364537051 4275 17250992
SGTC_2376 9072922 81.32 µM -1.26379552238269 0.132905022176446 no 2948 0.103151714373331 4344 17087968
SGTC_407 eburnamonine 100 µM -1.26380151496343 0.132903801554349 no 2949 0.103150638653251 4178 3195
SGTC_2618 avocadyne 43.43 µM -1.27021975836656 0.131600905924466 no 2950 0.1020031807277 4263 3015189
SGTC_2058 5236698 133 µM -1.27317873480938 0.131003215953256 no 2951 0.101477312377693 4301 766665
SGTC_2764 methyldopa 94.69 µM -1.27389125562171 0.130859572982632 no 2952 0.101350978918846 4328 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1524 corynanthine 62.1 µM -1.274996711813 0.130636930427733 no 2953 0.101155202921235 4429 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1619 st003326 88.7 µM -1.27510169225982 0.130615800641314 no 2954 0.1011366252508 4325 2849032
SGTC_351 caspofungin 25 nM -1.27566817851798 0.130501822724545 no 2955 0.101036420967905 4339 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_153 4077-0274 519.67 µM -1.27659938857153 0.130314611313593 no 2956 0.100871858927239 4397 3121976
SGTC_501 nsc-95397 161 µM -1.2778174389846 0.13007001379551 no 2957 0.100656901998383 4367 262093
SGTC_2973 9094665 17.96 µM -1.27910950954205 0.129810899742067 no 2958 0.100429247669459 4355 25237061 YIL048W NEO1
SGTC_3149 9097855 49.47 µM -1.28465890473702 0.128702079860335 no 2959 0.0994557524064904 4354 25236625 YMR079W SEC14
SGTC_922 1866-0035 480 µM -1.28560995773077 0.12851271237532 no 2960 0.0992896098783177 4271 3156169
SGTC_2492 derrusnin 100 µM -1.2868027575521 0.128275483326765 no 2961 0.0990815227824856 4384 1715307 Part of coumarin class of compounds.
SGTC_360 0957-0399 1.01 µM -1.2901095149882 0.12761941210521 no 2962 0.0985063183446466 4366 6752301 YPR165W RHO1
SGTC_1295 1013-0063 9.78 µM -1.29163935852252 0.127316676889351 no 2963 0.0982410335700672 4380 6826038
SGTC_510 ag-490 170 µM -1.29299134241146 0.127049553779047 no 2964 0.0980070267231236 4491 5328779
SGTC_1777 st045864 34.765 µM -1.29512491837035 0.126628798676558 no 2965 0.0976385700688343 4349 4691462
SGTC_842 0271-0008 11.1 µM -1.29815113767518 0.126033674479751 no 2966 0.0971177024056276 4401 1221709
SGTC_1623 st003709 20.3 µM -1.30317861391 0.125049307357237 no 2967 0.096256894795334 4343 16192618
SGTC_1442 4112-3290 3 µM -1.30565178673575 0.124567042059732 no 2968 0.0958355003632849 4364 704353
SGTC_2050 5263056 171 µM -1.30816324663489 0.12407864293336 no 2969 0.0954089725744052 4351 763468 YGL055W OLE1
SGTC_2552 juarezic acid 87.02 µM -1.30896270092614 0.123923455991687 no 2970 0.0952734928062638 4319 1549512
SGTC_965 1291-5240 308 µM -1.30952057850951 0.123815243480808 no 2971 0.0951790358544694 4373 2834598
SGTC_1215 3852-0577 11.2 µM -1.31183040371094 0.123367906546396 no 2972 0.094788682004588 4408 2884876
SGTC_2227 7312221 64.1025 µM -1.31378636574884 0.122989987601008 no 2973 0.0944590535592232 4487 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_363 0455-0021 3.06 µM -1.31392813468998 0.122962627458459 no 2974 0.0944351948435492 4332 4597466
SGTC_1490 4089-0339 670 nM -1.32407804499738 0.121014864627183 no 2975 0.0927385631387442 4345 742542
SGTC_1968 st069590 43.6 µM -1.32468402460722 0.12089926801588 no 2976 0.0926379869784841 4348 6384066
SGTC_1632 st005650 90 µM -1.32880372646931 0.120115453772084 no 2977 0.0919563662238466 4403 2759605
SGTC_219 mitoxanthrone 164.414 µM -1.33044221818978 0.11980471194813 no 2978 0.091686306173373 4320 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2062 5245942 200 µM -1.33211610664819 0.119487842862588 no 2979 0.0914110192063939 4432 1376160
SGTC_1546 5-methoxyflavanone 78.7 µM -1.33559955170333 0.118830319208683 no 2980 0.0908400983767232 4405 147795
SGTC_2812 7970281 58.44 µM -1.34165878160258 0.117692696053267 no 2981 0.0898533287081739 4422 2233435
SGTC_256 clotrimazole 625 nM -1.34242548006815 0.117549299321661 no 2982 0.0897290388336571 4332 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_996 3970-0799 1.8 µM -1.34574918328187 0.116929092718373 no 2983 0.0891917094270462 4378 6615648 YGL040C HEM2
SGTC_3064 1327-0027 10 µM -1.34812329037939 0.116487504052824 no 2984 0.0888093658075275 4339 16000455 YPR107C YTH1
SGTC_2490 carminic acid 95.39 µM -1.35110833853103 0.115933959497156 no 2985 0.0883303653726153 4359 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2549 cedrol 20.94 µM -1.35145584563245 0.115869639670997 no 2986 0.0882747274558358 4343 6708665 A sedative which affects the nervous system.
SGTC_3102 9121669 49.47 µM -1.35169948335315 0.115824560062467 no 2987 0.0882357352120918 4443 41905072
SGTC_305 1682-2595 20.8 µM -1.35464184012605 0.115281127245013 no 2988 0.0877658480856632 4420 226033
SGTC_2291 7917025 104.35 µM -1.35531068726018 0.115157849063574 no 2989 0.0876592957073118 4293 2964612
SGTC_419 nsc-638432 893 µM -1.35580553197745 0.115066702383545 no 2990 0.0875805253624389 4377 368090
SGTC_806 3966-4455 5.86 µM -1.35603006488316 0.115025362032579 no 2991 0.0875448012028082 4387 714982
SGTC_1066 ketoconazole 628 nM -1.35643525597568 0.114950786148209 no 2992 0.0874803610617591 4464 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_669 0108-0021 26.2 µM -1.3609822710165 0.114116260401836 no 2993 0.0867596461118207 4425 17201
SGTC_2399 5884133 200 µM -1.36144108943654 0.114032292554338 no 2994 0.0866871692482455 4369 722445
SGTC_1556 plumbagin 1.48 µM -1.36361020589445 0.113635920897386 no 2995 0.0863451391410919 4334 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1750 st081859 2.357 µM -1.36384857204002 0.113592423234792 no 2996 0.0863076147757696 4329 5291695
SGTC_2897 9048598 12.99 µM -1.36561082454889 0.113271211166489 no 2997 0.0860305736100022 4392 6467404
SGTC_1793 st048256 72.231 µM -1.36593227992057 0.113212688292644 no 2998 0.0859801099120531 4367 672022
SGTC_894 0960-0238 55.9 µM -1.36766036774405 0.112898449249195 no 2999 0.085709205441584 4406 6741907 YDL195W SEC31
SGTC_1436 4092-1007 8.32 µM -1.36991062895392 0.112490191059769 no 3000 0.0853574006815933 4413 2881121
SGTC_2816 7982706 58.44 µM -1.37068689802955 0.112349599828219 no 3001 0.0852362904246332 4405 2981853
SGTC_600 1495-0418 41.6 µM -1.37133083150355 0.112233071398517 no 3002 0.0851359243500206 4396 5377768
SGTC_1729 st035615 45.989 µM -1.37203707534748 0.11210536641778 no 3003 0.0850259481898109 4426 17385451
SGTC_514 4466-0038 2.65 nM -1.37539831337401 0.111499001591292 no 3004 0.0845039957992704 4206 5722064
SGTC_121 0557-0495 61.343 µM -1.37617032887851 0.111360062634001 no 3005 0.0843844529506203 4468 3104427
SGTC_2006 4011487 200 µM -1.37665708221226 0.111272525785096 no 3006 0.0843091468142002 4395 45595294
SGTC_3057 9095946 49.47 µM -1.3781844940554 0.110998158622348 no 3007 0.0840731667054669 4479 24540043
SGTC_1962 st076595 64.5 µM -1.3787859465754 0.110890253502117 no 3008 0.0839803804680263 4390 279619
SGTC_2965 9082772 38.63 µM -1.37890047548306 0.110869714672043 no 3009 0.0839627207818136 4424 16459634
SGTC_1603 st002045 67.8 µM -1.39296090923531 0.108368881809196 no 3010 0.0818158059586645 4416 5887985
SGTC_903 1134-0042 114 µM -1.39448458041411 0.108100334286281 no 3011 0.0815856613224781 4430 701009
SGTC_82 0054-0107 293.755 µM -1.39748050251121 0.107573699915556 no 3012 0.0811345629053105 4398 3104697
SGTC_1019 4262-0212 3.4 µM -1.39975170191147 0.107175693832482 no 3013 0.0807938427393479 4439 4677213
SGTC_1837 st055472 66.5 µM -1.40018016927047 0.107100728215398 no 3014 0.0807296863475872 4488 676091
SGTC_3303 9125618 40.5795 µM -1.40286225914928 0.106632322873454 no 3015 0.0803289585154503 4438 22695467
SGTC_1098 clofazimine 15.1 µM -1.40348854957785 0.106523159576756 no 3016 0.0802356020543006 4488 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2587 piperic acid 92.2 µM -1.40416237098665 0.106405801684155 no 3017 0.0801352520992426 4384 5370536
SGTC_1550 gossypolone 36.6 µM -1.40631198124944 0.106032033169418 no 3018 0.0798157519549459 4469 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1026 k007-1105 30.6 µM -1.41072829242658 0.105267115240337 no 3019 0.079162372647405 4405 7066794
SGTC_3021 9087658 49.47 µM -1.41226756589008 0.105001449157365 no 3020 0.0789355963245343 4444 25237042
SGTC_2432 5630864 12.22 µM -1.41584328581475 0.104386182923099 no 3021 0.0784106964978911 4443 5714970
SGTC_387 norethindrone acetate 66.7 µM -1.41725272312711 0.104144383377962 no 3022 0.0782045260466011 4456 541197
SGTC_963 1269-2853 151 µM -1.41771187191952 0.104065700710516 no 3023 0.0781374512899866 4424 3668223
SGTC_1251 0490-5699 265 µM -1.4191704398218 0.103816037157648 no 3024 0.0779246658690185 4464 3883818
SGTC_702 1488-0190 94 µM -1.420620938555 0.103568185965986 no 3025 0.0777134939883928 4485 949357
SGTC_431 k089-0097 107 µM -1.42068292107253 0.103557604396987 no 3026 0.0777044799076284 4180 5499420
SGTC_989 1501-0895 10.3 µM -1.42109203961645 0.103487779928976 no 3027 0.0776450019484175 4428 2830112
SGTC_1491 4138-0063 26.5 µM -1.4263441492033 0.102594433117583 no 3028 0.0768845133328479 4455 23883227
SGTC_1269 0831-0796 3.05 µM -1.42828869928667 0.10226510491613 no 3029 0.0766043895877154 4474 927758
SGTC_916 4466-0038 42 nM -1.42884522869964 0.102170992999354 no 3030 0.0765243613360831 4513 5722064 YGL116W CDC20
SGTC_3252 9135871 49.47 µM -1.43572024414159 0.101013586289267 no 3031 0.0755409811684815 4477 17682838
SGTC_1067 clotrimazole 1.36 µM -1.43954098948938 0.100374511327397 no 3032 0.074998652606735 4493 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1855 st056195 39.6 µM -1.44022148787863 0.100260998359509 no 3033 0.0749023728629438 4375 4028379
SGTC_226 1,3-diallylurea 8.28947 mM -1.44161437175808 0.100028945612837 no 3034 0.0747055958991623 4419 74537 YKL182W FAS1
SGTC_1702 st027038 51 µM -1.44242630884906 0.0998938589518999 no 3035 0.0745910732023799 4488 5521182
SGTC_2326 6164455 177.58 µM -1.44884103910178 0.0988312855012159 no 3036 0.0736909900033449 4405 2888790
SGTC_2016 5121758 140 µM -1.45251150937476 0.0982270196976878 no 3037 0.0731797156541151 4397 2795203
SGTC_428 3448-4153 16.5 µM -1.45426070722778 0.0979400050440394 no 3038 0.0729370199017886 4414 3834874
SGTC_2846 9008642 19.48 µM -1.45660406329012 0.0975564626658184 no 3039 0.0726128527108361 4484 2992898
SGTC_3010 9080089 71.4286 µM -1.45662793521061 0.0975525611704601 no 3040 0.0726095560856467 4480 17027233
SGTC_1181 1222-0449 220 µM -1.45924764106031 0.0971251058559943 no 3041 0.0722484803208964 4519 658318
SGTC_3341 9147222 25.867 µM -1.46025790909842 0.0969606290286823 no 3042 0.072109602662297 4485 1939759
SGTC_564 3555-0129 330 µM -1.46027473923792 0.0969578907281475 no 3043 0.0721072908219482 4370 563260
SGTC_1012 4112-3522 18 µM -1.46208900356757 0.0966630387753999 no 3044 0.0718584108528749 4480 3112398
SGTC_2942 9052777 62.25 µM -1.46336961848947 0.0964553117140996 no 3045 0.071683133660839 4484 6469503
SGTC_1928 4'-methoxychalcone 40.3 µM -1.46419148010897 0.096322171404242 no 3046 0.0715708187325112 4490 641818
SGTC_32 0928-0142 34.1 µM -1.46427658108612 0.0963083928983697 no 3047 0.0715591966222981 4475 2244242
SGTC_1507 4075-3230 155 µM -1.46761656610741 0.0957687670057624 no 3048 0.0711042027625227 4440 659771
SGTC_2338 7999974 200 µM -1.47403681839847 0.0947377297870103 no 3049 0.070235839112073 4467 315925
SGTC_2824 7998404 51.95 µM -1.47555264865318 0.0944954986284581 no 3050 0.0700320123521444 4447 837851
SGTC_1437 4092-1038 11.6 µM -1.47887203737612 0.0939666524605498 no 3051 0.0695872590364502 4540 3977136
SGTC_2769 toremifene 3.73 µM -1.4801696313945 0.093760514203773 no 3052 0.0694139913578035 4485 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_463 ikarugamyin 104 µM -1.48333535344647 0.0932590026478397 no 3053 0.0689926669142357 4637 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1037 k284-1091 78.7 µM -1.48430949183769 0.0931050798019259 no 3054 0.0688634166700896 4453 3334711
SGTC_2755 lomerizine 42.69 µM -1.48691676582049 0.0926940303901136 no 3055 0.0685183977943325 4427 3949 A calcium channel blocker.
SGTC_1800 st050079 29.0735 µM -1.48950716288514 0.0922869724179312 no 3056 0.0681769342810579 4304 3645560
SGTC_3310 9130229 44.1445 µM -1.49156362953788 0.0919647601234187 no 3057 0.0679067894111307 4505 7761258
SGTC_2520 obtusaquinone 4.71 µM -1.49382261097102 0.0916117783345436 no 3058 0.067610995001876 4521 5967872
SGTC_2259 7964009 200 µM -1.49400564476054 0.0915832220403584 no 3059 0.06758707194933 4505 313134
SGTC_643 k048-0106 28.4 µM -1.49640822245166 0.0912089915951635 no 3060 0.067273654077232 4512 6763920
SGTC_2188 6126565 140.678 µM -1.49776600688337 0.0909980024081298 no 3061 0.067097027776796 4401 874518
SGTC_2382 9035899 200 µM -1.49836562973065 0.0909049409923212 no 3062 0.0670191405665929 4490 6462679
SGTC_2607 solasodine 47.35 µM -1.49856880203399 0.0908734246886329 no 3063 0.0669927656382654 4449 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2614 arthonioic acid 13.39 µM -1.50025744495283 0.0906117942437366 no 3064 0.0667738640552065 4370 6710684
SGTC_1323 1348-1351 11.2 µM -1.50442223447499 0.0899689119312944 no 3065 0.0662363414062464 4485 6989654
SGTC_1888 azatryptophan 97.5 µM -1.50564191141873 0.089781284203819 no 3066 0.0660795616369322 4520 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2165 5727197 32.143 µM -1.5058345168101 0.0897516815672475 no 3067 0.0660548300518359 4544 1361712
SGTC_2214 7179297 48.276 µM -1.51121908815223 0.0889270299366242 no 3068 0.065366320332204 4561 769744
SGTC_1048 3161-0300 24.5 µM -1.51170069067737 0.0888535478320763 no 3069 0.0653050114262103 4506 2165101
SGTC_2851 9015922 71.43 µM -1.51197915932162 0.0888110801867181 no 3070 0.0652695822043255 4510 2996893
SGTC_393 acivicin 6.25 µM -1.51712662408084 0.0880287896315744 no 3071 0.0646173587288139 4361 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1073 triclabendazole 3.09 µM -1.51733609515 0.0879970642233548 no 3072 0.0645909247144169 4535 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2385 9074692 200 µM -1.51738537343359 0.0879896020274902 no 3073 0.0645847073060611 4509 17046906
SGTC_255 tunicamycin 200.472 nM -1.52016372486874 0.0875696399818752 no 3074 0.0642349159527461 4428 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_796 1234-0020 70.7 µM -1.52129058036295 0.0873997370046576 no 3075 0.0640934665204801 4448 46495034
SGTC_23 0213-0011 39.996 µM -1.52134115411809 0.0873921174601012 no 3076 0.0640871238921122 4501 627608
SGTC_3311 9131146 2.8755 µM -1.52218225008918 0.0872654689218961 no 3077 0.063981710684729 4445 4900406 YPR165W RHO1
SGTC_488 nitrendipine 139 µM -1.52932231460903 0.0861958636518351 no 3078 0.0630922801888161 4537 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2097 5376186 200 µM -1.53586286975475 0.0852247004179425 no 3079 0.0622860081765753 4486 742755
SGTC_135 0933-0004 26.348 µM -1.54007947622286 0.084602965583097 no 3080 0.0617704909382769 4449 21230617 YGL099W LSG1
SGTC_509 pifithrin 175 µM -1.54036634292511 0.0845607912714014 no 3081 0.0617355403317832 4598 4817 A p53 inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM -1.5421760390619 0.0842950984723037 no 3082 0.061515410516381 4485 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2683 piperine 63.03 µM -1.54263740041682 0.0842274634549271 no 3083 0.0614593891130204 4541 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1423 4048-0112 5.59 µM -1.54335993228806 0.0841216230107905 no 3084 0.0613717348202793 4571 X1423
SGTC_1785 bathophenanthroline 24 µM -1.54359750595716 0.0840868437332059 no 3085 0.0613429348039848 4446 72812 An iron chelator.
SGTC_1673 st016611 27.3 µM -1.54370073535766 0.0840717349688643 no 3086 0.061330424046606 4506 5226799
SGTC_2005 4024620 188 µM -1.54611539933971 0.0837189033616327 no 3087 0.0610383501753721 4468 236743
SGTC_1331 1472-0049 76.2 µM -1.550194035993 0.0831254595509294 no 3088 0.0605474754379449 4503 24051409
SGTC_2364 9055074 200 µM -1.5503251291293 0.0831064380374565 no 3089 0.0605317494108599 4504 6470630
SGTC_2675 theaflavin digallate 100 µM -1.55103021564197 0.0830041866707455 no 3090 0.0604472215341061 4451 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3035 9091303 49.47 µM -1.55226692229675 0.0828250685485983 no 3091 0.0602991845526118 4596 25237002
SGTC_2567 aureobasidin a 60 nM -1.5537951932528 0.0826041237146689 no 3092 0.0601166387431529 4584 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1192 1488-0095 21.4 µM -1.55461289240224 0.0824860898312002 no 3093 0.0600191457135845 4555 915875
SGTC_2098 5376439 882.5 nM -1.55628987368736 0.0822444169045372 no 3094 0.0598195891480536 4570 2844116
SGTC_794 k038-0031 316 µM -1.55781596617913 0.0820249526630258 no 3095 0.0596384400337765 4506 6624242
SGTC_3339 9145883 14.936 µM -1.56121715261261 0.0815374229096385 no 3096 0.0592362616188799 4446 2030670
SGTC_2586 curcumin 80 µM -1.56332919929232 0.0812357815046424 no 3097 0.0589875918608691 4424 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_486 niguldipine 82 µM -1.56918518510399 0.0804038364525511 no 3098 0.0583023976073357 4611 1236 A calcium channel blocker.
SGTC_2419 paclitaxel 166.5 µM -1.57126104740484 0.0801104745736437 no 3099 0.0580610125695959 4484 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_464 bw-b 70c 158 µM -1.57454919853806 0.0796474483925413 no 3100 0.0576802684344935 4528 5353454
SGTC_2568 diosmetin 100 µM -1.57807833352825 0.0791527434824375 no 3101 0.0572738075222797 4536 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2721 ifenprodil 61.44 µM -1.57916950924073 0.0790002572003593 no 3102 0.0571485908233951 4521 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_709 3807-1509 243 µM -1.5820976802986 0.0785921598443078 no 3103 0.0568136365529294 4602 1886677 YPL242C IQG1
SGTC_1798 st045719 60.953 µM -1.58241877893331 0.0785475059248221 no 3104 0.0567770002632737 4507 3980186
SGTC_1081 sertraline 6 µM -1.58275566803466 0.0785006767635994 no 3105 0.0567385823395619 4531 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1628 st004252 77.7 µM -1.58459970818659 0.0782447214701021 no 3106 0.0565286556549632 4526 692968
SGTC_1385 3091-4834 14.1 µM -1.58475356610248 0.0782233944219734 no 3107 0.0565111680734966 4525 4072814
SGTC_3130 9127414 49.47 µM -1.5852885045934 0.0781492781194944 no 3108 0.0564503998256232 4575 1494646
SGTC_2357 9067248 200 µM -1.58760217703078 0.0778293296386576 no 3109 0.056188162809563 4494 9150235
SGTC_847 0342-0274 5.54 µM -1.59895681546744 0.076273538241512 no 3110 0.054915099197626 4537 18097
SGTC_3256 9138902 49.47 µM -1.60525148891901 0.0754213119559708 no 3111 0.0542192351780725 4651 17228773
SGTC_1708 st033234 31.827 µM -1.60544736209563 0.0753949098878317 no 3112 0.0541976942345923 4617 674664
SGTC_783 0848-0141 92.7 µM -1.60610132312562 0.0753068124226252 no 3113 0.054125824615052 4484 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2055 5235184 200 µM -1.60785461612461 0.0750710071774389 no 3114 0.0539335117436236 4549 2836034
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.61555555693868 0.0740419500222932 no 3115 0.0530952196874286 4496 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2654 protoveratrine a 100 µM -1.62086953820771 0.0733381641723972 no 3116 0.0525228105286777 4557 5702278 A heart drug and vasodilator.
SGTC_719 2810-4230 27.3 µM -1.62135527738448 0.0732740887929799 no 3117 0.0524707331548981 4564 721079
SGTC_420 mitomycin C 81.9 mM -1.62363900293766 0.0729734092660469 no 3118 0.052226438099157 4533 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2641 levomentholum 100 µM -1.62396641716256 0.0729303788186128 no 3119 0.0521914880468398 4565 16666
SGTC_1658 st012944 20 µM -1.62634802029152 0.072617960654683 no 3120 0.0519378208941033 4403 24207260
SGTC_508 roscovitine 141 µM -1.62652900413915 0.0725942612046226 no 3121 0.0519185842282129 4614 160355 A CDKinase inhibitor.
SGTC_2723 salbutamol 83.58 µM -1.62790809523759 0.0724138666696398 no 3122 0.0517721873276911 4565 9884233 β2-adrenoceptor agonist
SGTC_2517 totarol 10 µM -1.6328872936967 0.0717654111904159 no 3123 0.0512463514924336 4564 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2456 5770359 74.46 µM -1.6339877205547 0.0716227021841555 no 3124 0.0511307144961188 4535 3118787
SGTC_1892 st058411 7.36 µM -1.63521342045154 0.0714640035501179 no 3125 0.0510021578847016 4557 3934738
SGTC_2649 anisomycin 9.56 µM -1.63554586933718 0.0714210059788543 no 3126 0.0509673336235321 4608 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2511 berberine 10.47 µM -1.63811696013365 0.0710891419517024 no 3127 0.0506986488326434 4546 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1353 1498-1206 8.11 µM -1.63927038007758 0.0709406493838369 no 3128 0.0505784809532011 4580 6756808
SGTC_3129 9127257 49.47 µM -1.64354611470929 0.0703922645754994 no 3129 0.0501349961877915 4497 837894
SGTC_1929 genistein trimethyl ether 50.5 µM -1.6441503210932 0.0703150355645359 no 3130 0.0500725778663117 4518 136420
SGTC_2037 5169046 200 µM -1.64633540230824 0.0700362846377296 no 3131 0.0498473622933536 4616 5718022
SGTC_2514 salinomycin 42.74 µM -1.64665787829565 0.0699952184516772 no 3132 0.0498141933314318 4589 23682228 A polyether potassium ionophore.
SGTC_1364 1653-0028 37.6 µM -1.64676268650757 0.069981875483431 no 3133 0.0498034168488908 4578 5718652
SGTC_2314 7727897 200 µM -1.64768583666599 0.0698644352115968 no 3134 0.0497085779595647 4536 900724
SGTC_947 3447-0010 211 µM -1.65195077193148 0.0693238316080191 no 3135 0.0492722933367613 4520 748350
SGTC_2301 7769476 200 µM -1.65403070471016 0.069061360536078 no 3136 0.0490606370981082 4563 977820
SGTC_1773 st048542 73.5835 µM -1.65840177489737 0.0685122626723282 no 3137 0.048618199297868 4548 3237138
SGTC_3087 9117406 49.47 µM -1.66144016087274 0.0681325662639062 no 3138 0.0483125387833373 4564 42546093
SGTC_2021 4019055 173 µM -1.66652624320495 0.0675006144203171 no 3139 0.0478043228317242 4356 44827708 YER133W GLC7
SGTC_2218 6965428 192.983 µM -1.67062753739428 0.0669943305307108 no 3140 0.0473976348927575 4491 675684
SGTC_258 haloperidol 50.781 µM -1.67064909787734 0.0669916767812098 no 3141 0.0473955042846747 4560 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1716 st033144 30.6155 µM -1.67226440386099 0.0667930896711904 no 3142 0.0472360977903135 4540 674617
SGTC_1852 st056254 31.4 µM -1.67268620514669 0.0667413081312718 no 3143 0.0471945431591879 4552 442583
SGTC_1519 esterone 74 µM -1.67295137117871 0.0667087714917905 no 3144 0.0471684347804101 4580 698 A steroid.
SGTC_2111 5486399 200 µM -1.67314233875189 0.0666853468221373 no 3145 0.0471496391913137 4542 689674
SGTC_2409 alverine citrate 63.97 µM -1.67382311053254 0.0666018930542068 no 3146 0.0470826844818375 4582 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_588 3970-1144 52.9 µM -1.67811282501074 0.0660778881012064 no 3147 0.0466625377575857 4501 1888707
SGTC_3000 9075062 71.4286 µM -1.68041058161202 0.0657985250194773 no 3148 0.046438729326358 4566 17057871
SGTC_2223 6903751 107.57 µM -1.68660612872981 0.0650498270661859 no 3149 0.0458395563596331 4554 5598863
SGTC_2271 7849410 118.62 µM -1.68690667411574 0.0650136766511843 no 3150 0.0458106492760395 4521 972430
SGTC_1591 genipin 88.4 µM -1.68925870370672 0.0647313064323175 no 3151 0.0455849317797399 4580 442424 A DNA cross-linking agent.
SGTC_792 4534-1957 155 µM -1.68990869390764 0.0646534408067833 no 3152 0.0455227120437009 4562 1717904
SGTC_551 k048-0028 34.9 µM -1.69739009418753 0.0637624349932991 no 3153 0.0448114670505415 4556 6836383
SGTC_815 1582-0027 36.9 µM -1.69823088104531 0.0636629005178709 no 3154 0.0447320971281621 4595 3128206
SGTC_3171 9103192 49.47 µM -1.70373806337803 0.0630139326415915 no 3155 0.0442150168341275 4650 13018434
SGTC_860 0443-0016 25.1 µM -1.70488098178096 0.0628798987346701 no 3156 0.0441083120100573 4598 5337942
SGTC_855 0428-0020 25 µM -1.70495863721675 0.0628707998839568 no 3157 0.0441010695043423 4613 6812414
SGTC_1346 1488-2224 62.4 µM -1.707147457993 0.0626147584977066 no 3158 0.0438973240245037 4604 3722427
SGTC_3134 9127454 49.47 µM -1.70881607365178 0.0624201156264199 no 3159 0.0437425121839139 4625 24262820
SGTC_2696 st077691 74.316 µM -1.71479945497784 0.0617260353867117 no 3160 0.043191000755168 4592 757133
SGTC_1941 st076221 61.8 µM -1.71565973120163 0.0616267395567372 no 3161 0.0431121695615759 4477 2828568
SGTC_2253 7938677 135.83 µM -1.72126326792422 0.0609830105675822 no 3162 0.0426015308619858 4626 2301972
SGTC_284 0988-0104 32.6 µM -1.72166529701733 0.0609370287034814 no 3163 0.0425650836014437 4581 4666532
SGTC_218 alverine citrate 93.75 µM -1.72413796545852 0.0606548143490792 no 3164 0.042341469872308 4642 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1220 1838-0075 193 µM -1.72565307511355 0.0604823953320915 no 3165 0.0422049223814268 4528 5529645
SGTC_689 0833-0039 98 µM -1.72718336728542 0.0603086380623759 no 3166 0.042067368503344 4561 5374726
SGTC_1774 st048371 48.465 µM -1.72720170568994 0.060306558196842 no 3167 0.042065722316012 4590 4242727
SGTC_1786 berberine 21.6 µM -1.72941231964078 0.0600562505846486 no 3168 0.041867663335419 4509 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2961 9083290 32.55 µM -1.73823347850751 0.0590655233076887 no 3169 0.0410848411473992 4578 17741490
SGTC_1651 st011928 86.1 µM -1.74247128021337 0.0585941461640761 no 3170 0.0407130063245937 4606 720198
SGTC_833 3852-0053 558 µM -1.74821909687906 0.0579595331420986 no 3171 0.0402130480114069 4647 3123681
SGTC_2963 9082507 9 µM -1.74886790104952 0.0578882396746106 no 3172 0.0401569281239553 4597 16459611
SGTC_1555 citronellol 128 µM -1.74976233257757 0.0577900686312392 no 3173 0.0400796664364579 4588 8842 A terpine precursor.
SGTC_975 1335-0046 28.5 µM -1.75242394662696 0.0574987092813187 no 3174 0.0398504683838836 4589 16486740
SGTC_3219 9131112 49.47 µM -1.75247664393622 0.0574929523432147 no 3175 0.0398459412690035 4485 17612988 YMR079W SEC14
SGTC_1203 3992-3522 103 µM -1.75535359239603 0.0571793465002043 no 3176 0.0395994224067682 4611 5322312
SGTC_3222 9128301 49.47 µM -1.75572464255422 0.0571389978618244 no 3177 0.0395677184994349 4564 4911358
SGTC_3307 9126885 69.2785 µM -1.75671171107093 0.0570317714219929 no 3178 0.0394834801844301 4587 24824909
SGTC_533 1222-0222 6.71 µM -1.76237857227449 0.0564192358859984 no 3179 0.0390026782616317 4633 3982874
SGTC_1531 st059297 52.4 µM -1.76403831186329 0.0562408184566543 no 3180 0.0388627645763751 4625 7566702
SGTC_809 3998-0021 90 µM -1.77016825049361 0.0555857196667742 no 3181 0.0383495583297878 4570 715485
SGTC_703 3875-0075 71.8 µM -1.77461699591286 0.0551140709359467 no 3182 0.037980574495186 4656 2850814
SGTC_821 1114-0266 29.2 µM -1.78074463462249 0.0544696117211951 no 3183 0.0374770889222348 4634 3123235
SGTC_1431 4049-0260 9.09 µM -1.78144331952031 0.0543965093835776 no 3184 0.0374200283437429 4651 3854841
SGTC_1447 4239-0816 81.9 µM -1.78187124996572 0.0543517740095805 no 3185 0.0373851149400692 4645 1341554
SGTC_1720 st037298 9.481 µM -1.78224565813984 0.0543126576711055 no 3186 0.0373545900661483 4600 597396
SGTC_2181 6316240 54.2555 µM -1.78542995931456 0.0539808770080996 no 3187 0.037095801376834 4641 12779990
SGTC_2719 novobiocin 32.65 µM -1.78636627704426 0.0538836254690392 no 3188 0.0370199860573537 4647 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1324 1418-0026 34.4 µM -1.79075458566775 0.0534296769846575 no 3189 0.0366663429704883 4640 1372513
SGTC_1763 st044482 94.5 µM -1.79240663467731 0.0532595680624454 no 3190 0.0365339263991072 4608 88505
SGTC_2939 9044578 71.43 µM -1.80021591736157 0.0524612619786163 no 3191 0.0359132757153657 4559 2653634
SGTC_1873 rapamycin 2 nM -1.80076868313656 0.052405117267578 no 3192 0.0358696734288441 4587 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1502 4534-4282 27.7 µM -1.80592584022535 0.0518835979320071 no 3193 0.0354649621001826 4630 3278949
SGTC_438 sphingosine 6.67 µM -1.80802472516898 0.0516725318679905 no 3194 0.0353013262472837 4580 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3198 9112019 49.47 µM -1.80843825797101 0.0516310271804106 no 3195 0.0352691590325302 4661 45595555
SGTC_2793 7325131 81.82 µM -1.8095783093157 0.0515167418837312 no 3196 0.035180603071138 4585 4176441
SGTC_2805 7950783 58.44 µM -1.81010935438115 0.0514635755955257 no 3197 0.0351394153149471 4616 1178958 YDL195W SEC31
SGTC_2076 5212012 200 µM -1.82119305412541 0.0503638441087388 no 3198 0.0342887579756657 4617 604802
SGTC_585 0kpi-0023 191 µM -1.82246940387962 0.0502384154541258 no 3199 0.0341918960382388 4579 64601
SGTC_3141 9094609 49.47 µM -1.82413400943612 0.0500752066198359 no 3200 0.0340659075361207 4582 25236309 YDL196W YDL196W
SGTC_1553 gossypol 38.6 µM -1.82493612483197 0.0499967130464613 no 3201 0.0340053344963242 4609 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_647 0140-0236 81 µM -1.82526958503175 0.0499641101163264 no 3202 0.0339801787895753 4651 990837
SGTC_550 4123-0385 25.7 µM -1.83462220256077 0.0490565768147918 no 3203 0.0332808433077114 4657 5731123
SGTC_555 4296-0685 37 µM -1.84395135850162 0.0481644866764393 no 3204 0.0325951146544284 4621 2908540 YHR072W ERG7
SGTC_2433 5607874 27.82 µM -1.85186929585453 0.0474175682972969 no 3205 0.032022296962606 4605 2252428
SGTC_3084 9116877 49.47 µM -1.8665901354508 0.0460536019374407 no 3206 0.030979423100967 4612 27241325
SGTC_1605 st000082 49.1 µM -1.86814352060806 0.0459115295315065 no 3207 0.0308710343746774 4627 1114022
SGTC_3060 1327-0027 12.5 µM -1.87079502034727 0.0456698374801473 no 3208 0.0306867490527477 4571 16000455 YPR107C YTH1
SGTC_2838 9002687 71.43 µM -1.88903522889511 0.0440347864603979 no 3209 0.029443554181312 4642 6457060
SGTC_2161 5662504 8.5105 µM -1.89684622744575 0.043349198545984 no 3210 0.0289241180691028 4663 2859334
SGTC_1221 2958-7315 257 µM -1.91500478447148 0.0417886668162476 no 3211 0.0277459467249438 4685 4562705
SGTC_1995 st072814 61.1 µM -1.92175490164907 0.0412202950845309 no 3212 0.0273183027191385 4669 5769371
SGTC_875 0709-0210 25.7 µM -1.92203030402223 0.0411972394474067 no 3213 0.0273009723727684 4655 6251364
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.93281461224581 0.0403026079551518 no 3214 0.0266295198089869 4609 6708739 YPR165W RHO1
SGTC_1093 fluphenazine 7.97 µM -1.93919320795831 0.0397809289452137 no 3215 0.0262389081761537 4687 6602611 An atypical antipsychotic.
SGTC_1422 4031-0024 15.5 µM -1.95431688456188 0.0385659461164574 no 3216 0.0253318766293583 4640 782427
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.9702865124084 0.0373160031688355 no 3217 0.0244027716664729 4678 2333 A French combination drug.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.97164859466515 0.0372109425709025 no 3218 0.0243248678440331 4654 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2526 patulin 37.61 µM -1.98052832078098 0.036531938040576 no 3219 0.023822097141246 4671 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3264 9137442 49.47 µM -1.9942966288914 0.0354991930253172 no 3220 0.023059823721736 4638 17015726
SGTC_137 0438-0332 85.389 µM -1.99460520558389 0.0354763241675997 no 3221 0.0230429776978387 4625 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2141 5621638 7.665 µM -1.99512484350376 0.0354378406979395 no 3222 0.023014632701224 4691 2856238
SGTC_690 glyoxal 20.3 µM -2.00582333465133 0.0346531074243741 no 3223 0.0224375500561339 4504 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2904 7225135 42.03 µM -2.01890751458848 0.0337128430245451 no 3224 0.021748416522735 4724 4446116
SGTC_1405 3909-7894 12 µM -2.02745313291654 0.0331101410885441 no 3225 0.0213080464172979 4692 7104060
SGTC_1020 4335-0961 93.3 µM -2.03343134210551 0.0326938118873107 no 3226 0.021004481764367 4656 669075
SGTC_122 0236-0016 402.397 µM -2.03530986688403 0.0325638841173773 no 3227 0.0209098519957305 4675 6808838
SGTC_2883 9059145 45.46 µM -2.04568930929935 0.0318536481923291 no 3228 0.0203934741165876 4691 16476510
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -2.05178657351352 0.0314424291512417 no 3229 0.0200952043591532 4669 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_536 3852-0578 10.6 µM -2.05423594846988 0.031278475790431 no 3230 0.0199764303264982 4697 2869208
SGTC_339 3091-4833 71.4 µM -2.05454420796947 0.0312578920614141 no 3231 0.0199615246197602 4525 3240077
SGTC_312 4092-0653 6.84 µM -2.05824543904516 0.0310116196038471 no 3232 0.019783289381486 4598 1148278
SGTC_1814 st052110 31.539 µM -2.07385451530154 0.0299906221408836 no 3233 0.0190464122018897 4655 674163
SGTC_2804 7954240 19.48 µM -2.07392566898414 0.0299860325543635 no 3234 0.0190431073439406 4676 828705
SGTC_1112 tnp00069 1.16933 µM -2.07496990016205 0.0299187440610915 no 3235 0.0189946622540123 4691 145826
SGTC_217 ketoconazole 989 nM -2.07634656013988 0.0298302258459277 no 3236 0.0189309549816162 4539 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.0774966379074 0.0297564433580213 no 3237 0.0188778726132028 4688 1377
SGTC_2142 5622915 118.518 µM -2.07917366379464 0.0296491262782501 no 3238 0.0188006956850301 4711 5322196
SGTC_1329 1447-1697 50.6 µM -2.09049336255884 0.0289331218088744 no 3239 0.0182867520061422 4704 2840515
SGTC_1552 6-methylflavone 10.6 µM -2.09469181664883 0.0286712370810857 no 3240 0.018099198581142 4689 689013
SGTC_1438 4092-1045 4 µM -2.10882600483324 0.0278040447512587 no 3241 0.0174798015412148 4743 1351342
SGTC_3298 9116858 71.43 µM -2.11643345718677 0.0273464139058193 no 3242 0.0171539795326147 4740 2506942
SGTC_1378 2093-0007 380 nM -2.11969008033907 0.0271524389623265 no 3243 0.017016095047003 4707 3618014
SGTC_2394 5221648 200 µM -2.1244208865672 0.0268727031454603 no 3244 0.0168174825027584 4703 788586
SGTC_1028 k015-0029 4.8 µM -2.13210330852893 0.0264235644250836 no 3245 0.0164991773557646 4711 4588309
SGTC_1735 st034310 56.75 µM -2.13251356401208 0.0263997571052192 no 3246 0.0164823253117957 4698 871153
SGTC_688 0527-0193 473 µM -2.13934092480366 0.0260061865207751 no 3247 0.0162040337764988 4731 4007154
SGTC_1560 lithocholic acid 53.1 µM -2.13970496023189 0.0259853398697022 no 3248 0.0161893089717593 4680 9903 A bile acid which acts as a detergent.
SGTC_1679 SEC14.276 6.7 µM -2.14301914358451 0.0257961938508655 no 3249 0.0160557806087652 4657 1005053 YMR079W SEC14
SGTC_139 0099-0334 718.624 µM -2.14304212114096 0.0257948865157007 no 3250 0.0160548581482866 4700 97690
SGTC_1100 amiodarone 5.07 µM -2.14864043220362 0.0254780123320728 no 3251 0.0158314570021729 4720 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1262 0737-0114 49.6 µM -2.14998431773433 0.0254024331835713 no 3252 0.0157782276358063 4720 765919
SGTC_2569 tetrandrine 100 µM -2.15029340592977 0.0253850768757911 no 3253 0.0157660068338643 4701 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.15869129823726 0.0249172957377306 no 3254 0.01543706216452 4721 803109
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.16382521050434 0.0246349015781949 no 3255 0.0152388832661282 4728 7104
SGTC_2251 lansoprazole 556 µM -2.16809363191217 0.0244021633572741 no 3256 0.0150757816357007 4709 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1114 scopoletin 1.73284 µM -2.1704791555095 0.0242728972915812 no 3257 0.0149852830219051 4738 5280460 A coumarin with genotoxic properties.
SGTC_3266 9136860 49.47 µM -2.18417377466402 0.0235418945340706 no 3258 0.0144747406157682 4496 4871271 YPR165W RHO1
SGTC_531 3788-1495 174 µM -2.18665562330123 0.0234114185146276 no 3259 0.0143838367332404 4712 2896655
SGTC_1728 st035614 33.7865 µM -2.19934784053166 0.022753637347139 no 3260 0.0139265992079531 4683 15945546
SGTC_2822 7994718 71.43 µM -2.20065969389005 0.0226865466806188 no 3261 0.0138800621170709 4726 1018011
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -2.20332520355134 0.0225507409514527 no 3262 0.0137859179033718 4707 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1060 3448-7350 82 µM -2.20351520083673 0.0225410869569639 no 3263 0.0137792283911261 4695 570178
SGTC_116 0155-0182 31.788 µM -2.21984928493199 0.0217240603318909 no 3264 0.0132145000475355 4622 771486
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.23053144170183 0.0212033858336592 no 3265 0.01285609125472 4701 5379071
SGTC_1841 st054148 70 µM -2.23159113696572 0.0211523140390588 no 3266 0.0128209989778734 4742 675442
SGTC_2170 morpholine 200 µM -2.23369841583668 0.0210510633529158 no 3267 0.0127514616559286 4744 121171 Reacts with secondary amines.
SGTC_3038 9091290 49.47 µM -2.2352680335157 0.0209759130130094 no 3268 0.0126998786854702 4716 25236843
SGTC_1688 st021091 57.6 µM -2.25134700552225 0.020219072836798 no 3269 0.0121817839040745 4767 3656366
SGTC_2272 7805186 180 µM -2.25166742101356 0.0202042292605381 no 3270 0.0121716484692479 4720 2956062 YPR165W RHO1
SGTC_3202 9113761 49.47 µM -2.25336685162362 0.0201256557719776 no 3271 0.0121180139020295 4664 4798415
SGTC_887 0885-0007 9.62 µM -2.26148787609499 0.0197537475515011 no 3272 0.0118645313069062 4736 5719458
SGTC_2 0422-0095 29 µM -2.26535000412069 0.0195789356033296 no 3273 0.0117456048857097 4667 6790840
SGTC_2623 humulene 100 µM -2.26686653014483 0.019510653027851 no 3274 0.0116991901953583 4709 6187145 An anti-inflammatory.
SGTC_909 3448-9333 149 µM -2.26857247846663 0.0194340834368638 no 3275 0.0116471684126251 4699 3344074
SGTC_1715 st032160 10.2275 µM -2.27039231057761 0.0193526838636243 no 3276 0.0115918953100524 4666 5289825
SGTC_2449 5812982 45.77 µM -2.2722208496431 0.019271186801284 no 3277 0.0115365872937715 4677 776185
SGTC_1989 st071868 50.2 µM -2.27987976020009 0.0189329951917018 no 3278 0.0113074103886945 4729 16414057
SGTC_640 3381-0960 37.1 µM -2.29000623639779 0.0184936050111582 no 3279 0.0110104775658286 4767 1745025
SGTC_1794 st048918 76.9 µM -2.29713565836046 0.0181894925398895 no 3280 0.0108055160808229 4741 672303
SGTC_2092 5303694 80.6725 µM -2.29739467477252 0.0181785246498586 no 3281 0.0107981326435691 4750 1963699
SGTC_2164 5685496 200 µM -2.29945359784337 0.0180915411269106 no 3282 0.0107395977052592 4723 759046
SGTC_1078 idebenone 36.1 µM -2.30276361798645 0.0179524461157031 no 3283 0.01064607328619 4759 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2108 5365811 200 µM -2.30775361008632 0.0177444787779535 no 3284 0.01050642222245 4738 780283
SGTC_1818 st052136 56.3 µM -2.31178088935757 0.0175781365268163 no 3285 0.0103948805426891 4504 674169
SGTC_2034 5197015 53.07 µM -2.33025154290937 0.0168321748325717 no 3286 0.00989643011180972 4742 780676
SGTC_2912 7964298 10.93 µM -2.34463850109818 0.0162700522283105 no 3287 0.00952276770261531 4721 2975850
SGTC_2287 7945887 168.79 µM -2.35251825084297 0.0159690486802467 no 3288 0.00932338733813682 4747 1245853
SGTC_1736 st036774 51 µM -2.35332410084755 0.015938536298258 no 3289 0.00930320434781661 4749 1272247
SGTC_2572 astragaloside iv 100 µM -2.36432554556626 0.0155269552810331 no 3290 0.00903146615103464 4715 45006101 An anti-inflammatory agent.
SGTC_2166 5933061 31.504 µM -2.3756219697136 0.015113864328916 no 3291 0.00875970060930069 4692 2877375
SGTC_171 k064-0041 9.68 µM -2.38559235625157 0.0147571452960777 no 3292 0.00852582013325335 4718 53325
SGTC_1363 1636-0063 10.4 µM -2.39582793058424 0.0143984955511785 no 3293 0.00829143651499745 4749 6072185
SGTC_3209 9113616 49.47 µM -2.40195874402224 0.0141872888765326 no 3294 0.00815377374355188 4741 16649353
SGTC_616 4092-0450 108 µM -2.4088704548012 0.0139523861616489 no 3295 0.00800098842917302 4753 787165
SGTC_1453 4237-0541 195 µM -2.41247020001088 0.0138313779416216 no 3296 0.00792241632735896 4751 739892
SGTC_3249 9135183 49.47 µM -2.42291217962909 0.0134854702164724 no 3297 0.00769832412240015 4728 4902779
SGTC_918 glabranin 770.725 nM -2.43862329542982 0.012979092626112 no 3298 0.00737166414436078 4741 124049 Also referred to as licorice root.
SGTC_743 1275-0778 158 µM -2.46106304276591 0.012284394644569 no 3299 0.0069263011238159 4753 2849257 YMR203W TOM40
SGTC_2279 7948423 32.93 µM -2.46142087900911 0.0122735827814564 no 3300 0.00691939588094606 4723 1247112
SGTC_1282 0886-0010 32.4 µM -2.46337724637074 0.0122146176574592 no 3301 0.00688175079795135 4763 2836211 YNL267W PIK1
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.46775200286929 0.0120836496408335 no 3302 0.00679822402641623 4719 279621
SGTC_1322 1348-1070 12 µM -2.48498218349282 0.0115795962520899 no 3303 0.00647789592900539 4754 6758089
SGTC_2244 6635614 200 µM -2.49774120071398 0.0112182040490671 no 3304 0.00624937020588295 4743 836499
SGTC_1059 3448-6867 171 µM -2.50671501394427 0.0109699360816724 no 3305 0.00609294588141696 4738 3934407
SGTC_3340 9146634 11.102 µM -2.50946628739171 0.0108947835565042 no 3306 0.00604568783496651 4754 4907387
SGTC_1843 st055809 45.5 µM -2.53354755014268 0.0102558933819275 no 3307 0.00564572097614344 4766 16413835
SGTC_162 k030-0015 37.8 µM -2.53603498295748 0.010191800378879 no 3308 0.00560577667778925 4763 1809920 YMR134W ERG29
SGTC_1156 4092-0367 4.88 µM -2.55096040558663 0.00981451056916835 no 3309 0.00537132647116616 4772 1357585
SGTC_3104 9120930 49.47 µM -2.55355905449163 0.00975008309590795 no 3310 0.00533140975887842 4758 17014836
SGTC_2598 perillyl alcohol 100 µM -2.56456885348252 0.00948120208468047 no 3311 0.0051652040379381 4750 10819 An apoptosis inducer.
SGTC_1646 st011709 75.6 µM -2.56766538205886 0.00940675668953969 no 3312 0.00511929683112271 4755 5757843
SGTC_1222 0366-0074 1.18 µM -2.57192847628793 0.00930510192764074 no 3313 0.00505668914186473 4773 286520
SGTC_3016 9080866 49.47 µM -2.57448925965038 0.00924450248046944 no 3314 0.00501941016461031 4765 17066299
SGTC_1672 st016598 6.51 µM -2.57967740797192 0.00912278585415697 no 3315 0.00494463239273011 4744 4665860 YNL267W PIK1
SGTC_2132 5317594 122.667 µM -2.60270869973786 0.00859924328696384 no 3316 0.0046245251363425 4735 794577
SGTC_2784 7567673 72.73 µM -2.61812727446448 0.00826365440726603 no 3317 0.004420691075041 4724 3471247
SGTC_3259 9138485 49.47 µM -2.64415154593303 0.0077232745843459 no 3318 0.00409479902342901 4752 17646153
SGTC_2911 7942208 15.64 µM -2.6518749028946 0.00756900533502688 no 3319 0.00400230964790023 4765 1243384
SGTC_3110 9122132 49.47 µM -2.76232103369268 0.00564173658776708 no 3320 0.00286960080312523 4771 918317
SGTC_156 3474-0145 5.642 µM -2.76842493207123 0.00554923205722084 no 3321 0.00281639801287644 4745 2265471
SGTC_1880 MG-132 525 µM -2.78746427942525 0.00526928721895541 no 3322 0.00265611552142602 4762 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1042 0350-0096 82 µM -2.7880968245833 0.00526020615406414 no 3323 0.00265093475506845 4775 3122515
SGTC_2216 7189485 200 µM -2.78954295779171 0.00523949717959919 no 3324 0.00263912468710292 4803 731273
SGTC_1854 st056233 32.9 µM -2.79005745559218 0.00523214695936278 no 3325 0.00263493443782731 4776 5393174
SGTC_299 1273-0059 1.44 µM -2.80402449426648 0.00503608418467259 no 3326 0.0025234535381569 4619 2848077
SGTC_1230 0170-0365 3.77 µM -2.81373680795598 0.00490363120256039 no 3327 0.00244846516312776 4780 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2281 7943571 200 µM -2.85073950638503 0.00442699488747116 no 3328 0.00218088435263818 4788 1244024
SGTC_1058 3448-5425 97.3 µM -2.85991933593823 0.00431535033197714 no 3329 0.00211874388393971 4774 7279705
SGTC_2958 9077254 16.72 µM -2.86782178278768 0.00422126427951541 no 3330 0.00206654137103264 4771 16457351
SGTC_1197 1601-0112 267 µM -2.93380029368092 0.00350460429263512 no 3331 0.00167419787501398 4786 7350313
SGTC_151 3013-0144 2.285 µM -2.95334223264544 0.00331441104076625 no 3332 0.00157176623176365 4636 906558 YHR107C CDC12
SGTC_868 0527-0199 213 µM -2.96818343093465 0.00317622442765545 no 3333 0.00149782750551662 4780 2849450
SGTC_649 1123-0311 367 µM -2.97609131658409 0.00310473121686662 no 3334 0.00145973957994467 4748 693629 YIL048W NEO1
SGTC_227 fluconazole 33.516 µM -3.01848556818068 0.00274558770830915 no 3335 0.00127020750628062 4795 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_845 0330-0138 4.51 µM -3.06261690826127 0.00241196849604348 no 3336 0.00109705375598136 4784 9039800
SGTC_2760 etidronate 98.04 µM -3.06263413164456 0.00241184578668204 no 3337 0.00109699062275726 4773 3305 A chelator and antioxidant.
SGTC_2516 gossypol 71.55 µM -3.12256079816727 0.00201754472014014 no 3338 0.000896425356783681 4789 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_128 0906-2981 13.371 µM -3.1587291277971 0.00180885940613752 no 3339 0.000792293467546978 4783 6740226
SGTC_2836 9010338 19.48 µM -3.24463287149934 0.00138957743202325 no 3340 0.000588010685197794 4771 2994051
SGTC_304 1310-0298 97 µM -3.26313574353041 0.00131179361802475 no 3341 0.000550933644492363 4686 1550234
SGTC_73 0327-0325 16.231 µM -3.29832893625066 0.00117473148128552 no 3342 0.000486310614978805 4727 53298
SGTC_1707 st032323 6.317 µM -3.29944455484078 0.00117060930740757 no 3343 0.000484381812334732 4722 3132057 YMR211W DML1
SGTC_1265 0819-1001 68.8 µM -3.33496980068781 0.0010460726660768 no 3344 0.000426543316360672 4779 3106768
SGTC_1842 st055362 61.2 µM -3.55198162874937 0.000514236996592628 yes 3345 0.000191170777128117 4799 676032
SGTC_1886 st057356 49.9 µM -3.55699244060224 0.000505637288582351 yes 3346 0.000187562473236016 4805 24207747
SGTC_2592 piperlongumine 83.33 µM -3.62224918249024 0.000405148499739798 yes 3347 0.000146026293332215 4794 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3204 9114183 49.47 µM -3.77718898536219 0.000235984611234308 yes 3348 7.93041902975522e-05 4785 17027248
SGTC_2905 7799065 20.05 µM -3.79366473399505 0.000222537814340204 yes 3349 7.42200356777579e-05 4800 1296806
SGTC_2596 sinensetin 100 µM -3.79999356807384 0.000217565308467336 yes 3350 7.23499217291361e-05 4796 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_310 1273-0058 1.06 µM -3.81059425022752 0.000209468162685234 yes 3351 6.93165725507448e-05 4603 2734232
SGTC_1108 betulinic acid 729.144 nM -3.81346647048141 0.000207323227033348 yes 3352 6.85155618708195e-05 4777 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2134 5324836 1.464 µM -3.94330935380704 0.0001292389666484 yes 3353 4.01824407100725e-05 4803 699272
SGTC_1044 1222-0021 1.78 µM -4.01089301846956 0.000100483055698226 yes 3354 3.02447583280095e-05 4786 4306703
SGTC_76 0433-0009 400.328 µM -4.68395802133531 6.62130301484131e-06 yes 3355 1.40693830537872e-06 4809 2841569
SGTC_2597 laccaic acid a 100 µM -5.89568667274417 1.84454945689329e-08 yes 3356 1.86563205855021e-09 4810 5491415 A textile dye.