SGTCid condition conc unit YNL266W|YNL266W.score YNL266W|YNL266W.strain.pval YNL266W|YNL266W.strain.significant YNL266W|YNL266W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2852 9023854 51.95 µM 5.2789195520064 3.69493268583498e-09 yes 1 6.49739188137639e-08 15 19798528 SGTC_2437 5741531 144.16 µM 5.27649596342322 3.75376315874866e-09 yes 2 6.58387061438415e-08 17 2262990 SGTC_2910 7948405 25.97 µM 5.17173546118777 7.381624535618e-09 yes 3 1.15964888384905e-07 11 2971328 SGTC_1558 st069300 45.6 µM 4.74337160217106 1.0257601618953e-07 yes 4 1.05095093428751e-06 6 24208000 SGTC_1851 st056236 18.9 µM 4.61098306233605 2.21543520102087e-07 yes 5 2.00384597369534e-06 8 5393171 SGTC_1552 6-methylflavone 10.6 µM 4.40117840215887 7.19932143037885e-07 yes 6 5.38322771992924e-06 8 689013 SGTC_2859 9028643 45.46 µM 4.17011408678973 2.48497143759583e-06 yes 7 1.52223595702848e-05 13 17151580 SGTC_2060 5238662 140 µM 4.12540585758007 3.13562679417059e-06 yes 8 1.85040772427582e-05 24 790130 SGTC_2472 5377652 49.4 µM 4.09221071049838 3.72107444439867e-06 yes 9 2.13640060777888e-05 51 1610903 SGTC_2015 5119600 184 µM 4.07245463210139 4.11767165075518e-06 yes 10 2.32601317414854e-05 26 2828786 SGTC_2171 5739187 198.077 µM 3.88607356291323 1.04705507849405e-05 yes 11 5.09393229633829e-05 19 2262761 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 3.72702526822791 2.24963127409931e-05 yes 12 9.68765202719903e-05 16 5393153 SGTC_2989 9073649 71.4286 µM 3.62507986861263 3.61718521194892e-05 yes 13 0.000144436080876336 53 21367202 SGTC_44 0929-0055 61.211 µM 3.57261715889473 4.59726509291635e-05 yes 14 0.000176715637812651 42 1379590 SGTC_2689 tacrolimus 100 µM 3.56279947026532 4.80655467252616e-05 yes 15 0.000183460481132496 64 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1742 st038235 28.8875 µM 3.42369944763658 8.92541082011732e-05 yes 16 0.000308874508340418 145 564103 YBR002C RER2 SGTC_2636 apigenin dimethyl ether 100 µM 3.29983247109463 0.000152026779768487 yes 17 0.000483712802256006 77 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2953 9074162 66.49 µM 3.29695721761999 0.000153885922054218 yes 18 0.000488691939887442 52 16451992 SGTC_421 streptovitacin 30 mM 3.28557411608721 0.00016145724170608 yes 19 0.000508873814775034 53 91467 include heat shock SGTC_1363 1636-0063 10.4 µM 3.24775725411483 0.000189188579397566 yes 20 0.000581592302736396 58 6072185 SGTC_2375 9072683 200 µM 3.22856619521185 0.000204907717736528 yes 21 0.000622062309020474 39 16798029 SGTC_2812 7970281 58.44 µM 3.17829383111999 0.000252058516693965 yes 22 0.000740722673577708 70 2233435 SGTC_1972 st070201 17.4 µM 3.17216373135434 0.000258454274868062 yes 23 0.000756538373050492 51 2829099 SGTC_299 1273-0059 1.44 µM 3.16882837326717 0.000261997401423053 yes 24 0.000765273726259532 47 2848077 SGTC_3071 9117417 49.47 µM 3.06763905032406 0.000393637324599047 yes 25 0.00107878527266662 44 45595590 YGL055W OLE1 SGTC_2014 4013930 200 µM 3.05133407384791 0.000419869418676202 yes 26 0.00113913465469786 84 64556 SGTC_2175 5807670 165.306 µM 3.04837398044935 0.000424802236843711 yes 27 0.0011504169623536 56 241186 SGTC_2259 7964009 200 µM 3.04769009074369 0.000425949515485072 yes 28 0.00115303810052218 72 313134 SGTC_1330 1469-0054 61.8 µM 3.03857010619173 0.000441526207400185 yes 29 0.00118851894950296 49 7102664 SGTC_3027 9089541 49.47 µM 2.98819198389219 0.000537509816426175 yes 30 0.0014031660565432 66 9943819 SGTC_1539 benzyladenosine 56 µM 2.93908570625793 0.000649328032774326 yes 31 0.00164591016162991 50 92208 A nucleotide analog. SGTC_2055 5235184 200 µM 2.8801396221544 0.000811769214069729 yes 32 0.00198749547318831 87 2836034 SGTC_2570 licareol 100 µM 2.85596118476193 0.000888621316861469 yes 33 0.00214533792580209 85 443158 SGTC_1432 4049-0298 68.4 µM 2.84229690837505 0.000934957559830032 yes 34 0.00223948788474513 43 741646 SGTC_1588 farnesol 29.9 µM 2.8319475566098 0.000971518680908413 yes 35 0.00231327180393617 56 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1798 st045719 60.953 µM 2.75887265916658 0.00126939347424446 no 36 0.00290005657473807 52 3980186 SGTC_1257 0669-0121 16 µM 2.74114159542356 0.00135327731525894 no 37 0.00306130581184268 104 4307855 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.71955185874613 0.00146224185956873 no 38 0.00326852218418189 72 688662 SGTC_1875 nocodazole 6 µM 2.71147596329821 0.00150501808769434 no 39 0.00334921987180963 103 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1497 4476-2978 41.3 µM 2.70753359034303 0.00152631190104367 no 40 0.00338926053828485 104 1528379 SGTC_2815 7968870 71.43 µM 2.70031278138245 0.00156602731063954 no 41 0.00346371570463772 103 2977326 YHR190W ERG9 SGTC_2601 securinine 100 µM 2.69411419085355 0.00160086942007878 no 42 0.00352879903333838 93 442872 A GABA receptor antagonist. SGTC_2647 atorvastatin 60.16 µM 2.68968794858348 0.0016261799640901 no 43 0.00357594305175783 74 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3248 9135562 49.47 µM 2.67929372261082 0.00168705672712958 no 44 0.00368888225153332 64 17650701 SGTC_1356 1502-0781 85.8 µM 2.62536804988344 0.00203749852110722 no 45 0.00432776749109633 89 567702 SGTC_412 gemfibrozil 100 µM 2.6118658836177 0.00213501393088501 no 46 0.00450247862809927 55 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1891 st059073 26.2 µM 2.61046699516147 0.00214535521147842 no 47 0.00452093482324744 103 688754 SGTC_1341 1486-1360 280 µM 2.59772552312593 0.00224165835136235 no 48 0.00469217367513711 106 3976547 SGTC_769 0302-0231 76 µM 2.57179886599037 0.00244980835154811 no 49 0.00505858250055449 166 571869 YER009W NTF2 SGTC_108 0509-0257 621.132 µM 2.5712070704388 0.00245475723995535 no 50 0.00506723552592913 156 536624 SGTC_2936 9038235 15.59 µM 2.53103108094285 0.00281263869553302 no 51 0.00568638852272067 128 4749415 SGTC_1338 1486-1223 76 µM 2.52874650500575 0.00283433759346155 no 52 0.00572353354191665 106 3444526 SGTC_2172 5754775 163.918 µM 2.52245106240319 0.00289491522780406 no 53 0.00582700822706971 115 2263357 SGTC_2032 5185112 25.99 µM 2.51672711446533 0.00295100426512685 no 54 0.00592252656277604 87 5718189 SGTC_1861 st057647 17.4 µM 2.51156907438734 0.00300238494161467 no 55 0.0060097880317035 114 688668 SGTC_1953 st076800 12.1 µM 2.46854293354282 0.00346338780942342 no 56 0.0067832188391818 175 297591 SGTC_803 4488-1585 147 µM 2.46143514148197 0.00354538608777815 no 57 0.00691912078095545 99 747204 SGTC_1064 honokiol 6.76 µM 2.45316934173491 0.00364293261047577 no 58 0.00708018294865829 130 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1970 st070122 35.8 µM 2.45057852041037 0.00367399941446579 no 59 0.0071313425507868 142 102928 SGTC_2282 7944268 200 µM 2.42500446295021 0.00399365230764437 no 60 0.00765409928200126 163 2970414 SGTC_1888 azatryptophan 97.5 µM 2.42125885813057 0.00404250348215143 no 61 0.00773342950480388 90 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3237 9133362 49.47 µM 2.38939412044237 0.00448020955803578 no 62 0.00843809373902921 147 43845137 SGTC_2634 4'-methoxyflavone 100 µM 2.37949028896505 0.00462462323958721 no 63 0.00866829990506339 143 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_519 k048-0011 62.8 µM 2.36524735442854 0.00483959137657032 no 64 0.0090090161188751 136 6836379 SGTC_808 0711-0032 135 µM 2.35929320243386 0.00493206658168293 no 65 0.00915489137813626 115 4252555 SGTC_1372 2752-0194 270 µM 2.35069063807372 0.00506845558258337 no 66 0.00936930299937058 117 823334 SGTC_1565 sinapyl alcohol 95.1 µM 2.32141592969305 0.00555809249639927 no 67 0.0101322033093538 159 5280507 A phenol propionate derived from cinnamic acid. SGTC_1144 3486-0183 12.5 µM 2.29619122733815 0.00601322693033959 no 68 0.010832474962225 171 6744069 SGTC_1749 st037932 54.2 µM 2.27398772372399 0.00644087410041144 no 69 0.0114833623226602 158 594497 SGTC_2248 tofa 1.1 µM 2.26812968595594 0.00655809641050535 no 70 0.0116606517475349 160 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1293 1000-1278 195 µM 2.26615875703722 0.00659795771774603 no 71 0.0117208324003758 163 678847 SGTC_699 0375-0592 111 µM 2.24136973963484 0.00711790403109255 no 72 0.0125010674774006 144 762578 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.24023914860646 0.00714245702611872 no 73 0.0125377006876008 103 688803 SGTC_507 nimesulide 162 µM 2.22496402007362 0.00748158508712897 no 74 0.0130418268127333 163 4495 A COX2 inhibitor. SGTC_2041 5107442 45.335 µM 2.21564151062943 0.00769545803689932 no 75 0.013358031781082 193 793005 SGTC_2950 9072895 21.46 µM 2.20241271016898 0.00800817902378657 no 76 0.0138180844379446 231 17332245 SGTC_1860 st056228 74.6 µM 2.20210663224234 0.00801554488077753 no 77 0.0138288885562269 159 688679 SGTC_1421 4029-0249 71.4 µM 2.19514582215344 0.00818467447673762 no 78 0.0140765695746393 182 2894095 SGTC_2435 5706476 10.6 µM 2.18845728429247 0.00835013419569031 no 79 0.0143181547506167 189 5725375 SGTC_1556 plumbagin 1.48 µM 2.18406238113252 0.00846044675058827 no 80 0.0144788322515629 121 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_688 0527-0193 473 µM 2.18104792235999 0.00853684757859874 no 81 0.0145899360602869 128 4007154 SGTC_2597 laccaic acid a 100 µM 2.16119929691813 0.00905518953706932 no 82 0.015339973856243 210 5491415 A textile dye. SGTC_1553 gossypol 38.6 µM 2.15661658627621 0.00917871103786935 no 83 0.0155177755528679 80 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2447 5741742 33.78 µM 2.15133928836987 0.00932277932101289 no 84 0.0157247146842129 190 1776504 SGTC_2071 5230951 39.92 µM 2.14914870547091 0.0093831600894062 no 85 0.0158113069515151 174 1799272 SGTC_991 3996-0057 64.7 µM 2.14891840593459 0.0093895278461133 no 86 0.0158204342490868 170 715343 SGTC_1728 st035614 33.7865 µM 2.14775292789672 0.00942181118642971 no 87 0.0158666941362364 265 15945546 SGTC_1113 artemisinin 1.17947 µM 2.14148269058816 0.00959716594613279 no 88 0.0161175664426911 164 2240 An anti-malaria and mitochondrial poison. SGTC_3201 9113999 49.47 µM 2.13193811874542 0.00986956727769879 no 89 0.016505967012088 205 16649224 SGTC_2460 5552655 174.22 µM 2.12705875813451 0.0100114141270226 no 90 0.0167076007033412 207 5401989 SGTC_2019 4016004 108 µM 2.12649293214601 0.0100279777148427 no 91 0.0167311185686018 188 45595336 SGTC_727 3032-0951 202 µM 2.12304158349127 0.0101295288483977 no 92 0.016875183715935 179 3652836 SGTC_2396 5342950 42.78 µM 2.12233432150278 0.0101504494676231 no 93 0.0169048366367068 242 1886677 SGTC_2004 4023728 41.89 µM 2.11850048755806 0.0102645104582289 no 94 0.0170663518332791 216 360084 YDR527W RBA50 SGTC_1339 1486-1321 22.7 µM 2.11657557874483 0.0103221990478428 no 95 0.0171479422831805 203 3469382 SGTC_40 0327-0103 19.753 µM 2.09380618479182 0.0110263302162819 no 96 0.0181386245020841 226 409036 SGTC_2373 9071805 200 µM 2.08896122243486 0.0111814371580047 no 97 0.0183556069844044 169 10149009 SGTC_2329 6138490 200 µM 2.07559109241638 0.0116193488598751 no 98 0.018965892990642 192 720019 SGTC_2745 rifampicin 24.3 µM 2.06111179891432 0.0121103101219248 no 99 0.0196461877158634 94 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1999 st074831 12.5 µM 2.06106323695634 0.0121119865548539 no 100 0.0196485037610163 219 17112523 SGTC_523 1934-0222 13.7 µM 2.06044760494085 0.0121332565591852 no 101 0.019677884945125 220 1361595 SGTC_292 k038-0015 474 µM 2.05945396687844 0.0121676549259754 no 102 0.0197253852437597 185 46368540 SGTC_111 0083-0039 52.457 µM 2.05849159860848 0.0122010513208148 no 103 0.0197714834632356 89 759313 SGTC_1730 st033808 45.1 µM 2.03694945214723 0.0129696813316533 no 104 0.0208275538625334 276 1045166 SGTC_2121 5257820 149.641 µM 2.03643842628485 0.0129884120746204 no 105 0.0208531750744851 213 791256 SGTC_3058 9093861 49.47 µM 2.02959165625947 0.013241632890521 no 106 0.0211990318682474 220 17217477 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.0209409737817 0.0135676590900765 no 107 0.0216429378604515 220 16486 A toxic proline analog. SGTC_185 k048-0037 25.491 µM 2.01964026874672 0.0136172742934839 no 108 0.021710357496929 161 6827589 SGTC_164 4100-3994 89.624 µM 2.01387207703966 0.0138391923616831 no 109 0.0220114829312824 275 4615967 SGTC_2008 4012253 172 µM 2.00854922266644 0.0140467371364802 no 110 0.0222924804663238 256 603940 SGTC_2085 5307070 144.047 µM 2.00390299577563 0.0142300866748461 no 111 0.022540226294659 193 2840351 SGTC_938 3126-1755 342 µM 1.99360122097774 0.0146439817698219 no 112 0.0230978259185383 195 1777771 SGTC_1142 3253-1408 9.78 µM 1.99111555565716 0.0147453857932737 no 113 0.0232340923323792 203 256655 SGTC_1725 st036284 20.55 µM 1.98619363732591 0.0149479611218175 no 114 0.0235059135427664 259 707914 SGTC_545 4218-0007 221 µM 1.98613802068149 0.0149502637827689 no 115 0.0235090002862109 226 2840508 SGTC_431 k089-0097 107 µM 1.98139554362257 0.0151477384549671 no 116 0.0237734665666593 307 5499420 SGTC_1748 st037455 53.6035 µM 1.97841221394676 0.0152731079455204 no 117 0.0239411114850564 257 580690 SGTC_2659 sanguinarine 24.21 µM 1.96986032214636 0.0156374372845379 no 118 0.0244271904517605 219 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_809 3998-0021 90 µM 1.96277517260932 0.0159449042565607 no 119 0.0248361519349505 186 715485 SGTC_2819 7996655 46.38 µM 1.95143498418406 0.0164478071609325 no 120 0.0255026616270396 199 6456960 SGTC_3297 9117502 71.43 µM 1.9439631410326 0.0167865311889933 no 121 0.0259499480398543 184 7453720 SGTC_2947 9072639 7.68 µM 1.93939095053577 0.0169967329215622 no 122 0.0262268758044702 308 16488146 SGTC_2603 homopterocarpin 100 µM 1.93445279916375 0.0172262828518114 no 123 0.0265287400541533 277 101795 A weak amylase inhibitor. SGTC_1054 3429-0080 167 µM 1.93092684153974 0.0173918032207468 no 124 0.0267460501306635 260 1162877 SGTC_2439 5492030 7.2 µM 1.92849081046986 0.017506950456411 no 125 0.0268970530918166 211 5722370 SGTC_1226 3909-7979 35.4 µM 1.91852742288954 0.0179847023763526 no 126 0.0275220841766883 282 6615510 SGTC_1859 st055998 20 µM 1.91356758704707 0.0182266458384609 no 127 0.0278377149548956 242 676301 SGTC_115 0527-0192 112.043 µM 1.90310491266446 0.0187461286132274 no 128 0.0285134285273625 376 4233931 SGTC_867 0518-0118 155 µM 1.9018987358397 0.0188068187932118 no 129 0.0285921972515853 243 6848158 SGTC_1058 3448-5425 97.3 µM 1.90178403376578 0.0188125988559109 no 130 0.0285996972232831 242 7279705 SGTC_2742 clothiapine 36.27 µM 1.90145667465573 0.0188291034375786 no 131 0.0286211111021478 184 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1353 1498-1206 8.11 µM 1.89338943840485 0.0192397419728105 no 132 0.0291530494635359 323 6756808 SGTC_1983 st071813 46.9 µM 1.88995930181493 0.0194166354084119 no 133 0.0293817016771033 237 11838595 SGTC_513 4245-1575 41.7 µM 1.88653787243886 0.0195944543790099 no 134 0.0296112549305385 413 719745 SGTC_3295 9122362 53.5725 µM 1.87849652563215 0.0200178318547878 no 135 0.0301566359560699 230 4730473 SGTC_3308 9128332 17.569 µM 1.87809936848097 0.0200389417741326 no 136 0.0301837863605328 360 17332805 YDL196W YDL196W SGTC_641 4092-0595 30 µM 1.86204043929336 0.0209084734282382 no 137 0.0312986951596322 267 786260 SGTC_3213 9129884 49.47 µM 1.86075701786239 0.020979323651831 no 138 0.0313892489285847 219 17190742 SGTC_1169 aniline yellow 25.8 µM 1.85034824623476 0.021561472191379 no 139 0.0321316865574607 219 6051 A DNA damaging agent. SGTC_3232 9132874 49.47 µM 1.8474861904519 0.0217239158350882 no 140 0.0323383538675896 243 3784940 SGTC_605 1315-0399 119 µM 1.84427035577544 0.0219076714429687 no 141 0.032571874731701 300 24020461 SGTC_618 k072-0232 33.2 µM 1.83836610596237 0.0222484630797505 no 142 0.0330042380300228 240 5872756 YGL099W LSG1 SGTC_2678 equilin 100 µM 1.83652017290173 0.0223559233585649 no 143 0.033140380690685 279 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2994 9053520 71.4286 µM 1.83525376063577 0.0224299000036771 no 144 0.0332340494144234 276 4647384 SGTC_2483 5729050 27.16 µM 1.83328474308684 0.0225453288562465 no 145 0.033380118543404 351 2865180 SGTC_3075 9116269 49.47 µM 1.82860399449487 0.0228217381692364 no 146 0.0337294769349293 245 17015205 YNL244C SUI1 SGTC_342 k048-0088 23.3 µM 1.82739971284233 0.0228933139254239 no 147 0.0338198462476738 272 6820570 SGTC_2713 st079149 53.4 µM 1.81087862898308 0.0238944787147289 no 148 0.0350798206967428 296 3103253 SGTC_512 prima-1 270 µM 1.81050576787439 0.0239174918387091 no 149 0.0351086953554415 274 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2143 5623677 140.463 µM 1.81024109696872 0.0239338387259038 no 150 0.0351292035118352 210 5375313 SGTC_1920 st075728 45.7 µM 1.80931072673773 0.0239913757802938 no 151 0.0352013717278852 284 3400306 SGTC_3045 9092950 49.47 µM 1.80333380912056 0.0243637856701948 no 152 0.0356679029901455 289 44120432 SGTC_2325 6158266 200 µM 1.80017361779113 0.0245626446390932 no 153 0.0359166141025028 286 3623240 SGTC_2382 9035899 200 µM 1.79635149712098 0.0248049745638475 no 154 0.0362193162802776 281 6462679 SGTC_2116 5511452 16.8835 µM 1.79602193288011 0.0248259631649428 no 155 0.0362455144465563 297 870744 SGTC_2395 5646831 180.19 µM 1.77987468657826 0.0258727097554287 no 156 0.0375482356108088 300 6808628 SGTC_1652 st011932 78 µM 1.77978317682515 0.0258787455227725 no 157 0.0375557259307509 267 1551076 SGTC_988 1497-1057 103 µM 1.77624731022877 0.0261128667830329 no 158 0.0378460817649727 302 3533044 SGTC_107 0358-0022 2.6945 µM 1.77350690256634 0.0262955342031376 no 159 0.0380723745655313 185 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1908 st060353 56.5 µM 1.76444749769383 0.0269070260033274 no 160 0.0388283336778462 354 4227716 SGTC_1799 st045822 46.1415 µM 1.76405749130329 0.026933614978881 no 161 0.0388611501691608 261 3674992 SGTC_495 decylubiquinone 155 µM 1.75797541985889 0.0273511106573776 no 162 0.039375845863879 297 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3299 9121982 43.1275 µM 1.75705645034131 0.0274146590130928 no 163 0.0394540938710724 302 17594604 YPL160W CDC60 SGTC_1755 st041960 45.185 µM 1.75578731590153 0.0275026242797646 no 164 0.0395623654937562 286 2257073 SGTC_2056 5235370 200 µM 1.75142044781193 0.0278070970235862 no 165 0.0399367566694866 328 5511916 SGTC_1974 st069448 26.9 µM 1.75115337685473 0.0278258088825765 no 166 0.0399597469819201 265 6323587 YNR016C ACC1 SGTC_3050 9093513 49.47 µM 1.74761063616723 0.0280750189000991 no 167 0.0402657361656404 281 25236664 SGTC_3251 9135047 49.47 µM 1.74539634070565 0.0282317227410465 no 168 0.0404579511054289 221 17682963 SGTC_2484 5809818 12.04 µM 1.74509407212258 0.0282531704059817 no 169 0.0404842476364294 296 2870548 SGTC_245 methotrexate 289.6 µM 1.74314057321105 0.0283921094890253 no 170 0.0406545314490776 341 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2761 levamisole 97.89 µM 1.74112203828628 0.0285362709182635 no 171 0.0408310945476584 294 26879 An alkaline phosphatase inhibitor. SGTC_3043 9092303 49.47 µM 1.735706191072 0.0289260755784686 no 172 0.0413078991294329 295 25236084 SGTC_3215 9129942 49.47 µM 1.73550253339944 0.0289408197213059 no 173 0.041325916579344 250 17682944 SGTC_2519 cryptotanshinone 88.04 µM 1.73409054490055 0.0290432148904435 no 174 0.041451009445456 257 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2176 5809774 33.9695 µM 1.73372010550315 0.0290701283620959 no 175 0.0414838786931953 290 2870539 SGTC_3282 9108498 15.4605 µM 1.72473795117621 0.0297290765747759 no 176 0.0422873541796483 324 16459645 SGTC_1765 st044815 90.4 µM 1.71314717907993 0.0305976664294217 no 177 0.0433427331440978 317 645695 SGTC_1145 3546-0597 10.2 µM 1.70834473034549 0.0309636597941523 no 178 0.0437861980537938 353 875334 SGTC_296 1222-0039 74.9 µM 1.69902300745542 0.03168440834447 no 179 0.0446574243391134 314 5984176 SGTC_1453 4237-0541 195 µM 1.69840512251805 0.0317326686361163 no 180 0.0447156629769094 309 739892 SGTC_1402 3909-7673 35.9 µM 1.69628165778007 0.0318989864205109 no 181 0.0449162762162694 314 5328014 SGTC_946 3434-1334 87.4 µM 1.69215313059446 0.0322244090928752 no 182 0.0453083901772957 322 4047976 SGTC_880 0833-0487 87.2 µM 1.69090348422478 0.0323234484298703 no 183 0.0454276188736076 326 76075 SGTC_1434 4073-0095 163 µM 1.69081547074939 0.0323304332986398 no 184 0.0454360257375932 306 24133745 SGTC_318 1488-0629 67.2 µM 1.68492003109783 0.0328011471226479 no 185 0.0460020006555284 300 3662576 SGTC_2204 7233102 200 µM 1.68427026101731 0.0328533711165011 no 186 0.0460647250020535 264 2172480 SGTC_1979 st071809 45.3 µM 1.6822842947015 0.0330134142926899 no 187 0.0462568625391561 320 4976333 SGTC_1682 st012968 530 nM 1.67294563775341 0.0337746252571954 no 188 0.0471689991738138 292 24207270 SGTC_2860 9025725 38.96 µM 1.66943709792254 0.0340643193367936 no 189 0.0475153933346092 299 40546248 SGTC_1115 galangin 695.678 nM 1.66873209841402 0.03412277575716 no 190 0.0475852424143997 369 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2779 methotrexate 400 µM 1.66657363142702 0.0343022622971214 no 191 0.04779960786981 348 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1657 st012939 43.4 µM 1.66646091087836 0.034311656812066 no 192 0.0478108237796892 286 24207257 SGTC_95 0471-0001 561.058 µM 1.665836812537 0.0343637095685731 no 193 0.0478729608921886 354 4015405 SGTC_2621 lithochol-11-enic acid 100 µM 1.65751347890166 0.0350641393302871 no 194 0.0487078530268385 390 6708711 SGTC_1332 1480-0653 17.5 µM 1.6503490463077 0.0356763878776076 no 195 0.0494357831169758 351 5749438 SGTC_2916 7875993 68.79 µM 1.64908986134935 0.0357848936522223 no 196 0.0495646132031303 356 1299250 SGTC_1376 2910-0861 41.3 µM 1.6474078043104 0.0359302606559353 no 197 0.0497371261543276 375 1112859 SGTC_2685 mycophenolic acid 18.85 µM 1.64728479044249 0.0359409107351456 no 198 0.0497497613174661 283 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1641 st009299 47.1 µM 1.64629240677081 0.0360269222004369 no 199 0.0498517860225959 265 4046054 SGTC_446 go6976 132 µM 1.64080143301914 0.0365058855575927 no 200 0.0504193203589485 298 3501 A protein kinase C inhibitor. SGTC_1591 genipin 88.4 µM 1.64033956661107 0.0365464094112639 no 201 0.0504672915857071 293 442424 A DNA cross-linking agent. SGTC_287 k060-0039 29.6 µM 1.63358837678046 0.0371429663097789 no 202 0.051172655015924 330 5861974 SGTC_1824 st053723 68.6 µM 1.62974415590433 0.0374861945814504 no 203 0.0515777904095265 367 675225 SGTC_2128 5255449 168.493 µM 1.62750585038447 0.037687230191828 no 204 0.051814853546299 380 736008 SGTC_1967 st070177 51.4 µM 1.62624574256992 0.0378007946749045 no 205 0.051948694436856 319 5729214 SGTC_1320 1313-0481 95.3 µM 1.6252296552215 0.0378925706080303 no 206 0.0520568169107309 344 6813365 YLR208W SEC13 SGTC_1587 estradiol valerate 56.1 µM 1.6248509248155 0.0379268251097459 no 207 0.0520971635510045 364 13791 A steroid. SGTC_3021 9087658 49.47 µM 1.62384559354025 0.0380178754711037 no 208 0.0522043832826487 274 25237042 SGTC_198 3454-2873 16.191 µM 1.62367162397998 0.0380336495468424 no 209 0.0522229551105214 349 710957 SGTC_658 3253-0951 102 µM 1.62322191728667 0.0380744498535603 no 210 0.0522709871054399 472 1184878 SGTC_3188 9110789 49.47 µM 1.62006934863008 0.0383614747214733 no 211 0.0526086904084691 367 849217 SGTC_1466 k213-0079 57.5 µM 1.61083872175761 0.0392120316513821 no 212 0.0536074394661536 369 3657981 SGTC_410 α-linolenic acid 100 µM 1.60598098566147 0.0396657753601299 no 213 0.0541390439082732 389 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2716 st080858 38.6235 µM 1.60526878891523 0.039732656551982 no 214 0.0542173323567464 329 5296050 SGTC_3198 9112019 49.47 µM 1.60396677819545 0.0398551631904439 no 215 0.054360687850899 347 45595555 SGTC_1107 amlodipine 47 µM 1.6021252129879 0.0400289607677358 no 216 0.0545639618060283 387 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2005 4024620 188 µM 1.59474432107942 0.0407317220703218 no 217 0.055384711274958 345 236743 SGTC_2393 9031399 185.94 µM 1.59387681457009 0.0408149740273624 no 218 0.0554818141940072 377 1526623 YDL150W RPC53 SGTC_775 4577-0580 57.3 µM 1.58788528028187 0.0413937396493757 no 219 0.056156141292858 357 2006902 SGTC_188 3229-0966 278.469 µM 1.5830040042724 0.0418701586621479 no 220 0.0567102758580237 451 5722370 SGTC_2624 nerol 100 µM 1.58207974894274 0.0419608652107858 no 221 0.056815683009961 342 637566 A natural product oil. SGTC_2220 6782180 200 µM 1.57767934701826 0.0423949052419089 no 222 0.05731964666021 280 833803 SGTC_1642 st009582 77.7 µM 1.57557782095952 0.0426034698997933 no 223 0.0575615654157076 339 6739311 SGTC_2415 st077333 57.7 µM 1.56910697611407 0.0432508795519674 no 224 0.0583115072761591 460 2766255 SGTC_2107 5363541 170.161 µM 1.56886967208559 0.0432747720758946 no 225 0.058339154945399 383 244052 SGTC_1655 st012546 55.1 µM 1.56528559724918 0.0436369258903702 no 226 0.0587579793474869 356 720985 YLR208W SEC13 SGTC_973 1325-0077 65.9 µM 1.56300778927948 0.0438683559823124 no 227 0.059025381357945 418 2835149 SGTC_2879 9041815 71.43 µM 1.56113805269577 0.0440590641563569 no 228 0.0592455906907981 251 4942971 SGTC_3265 9137266 49.47 µM 1.55710768245809 0.0444724249113575 no 229 0.0597224606818333 319 17224265 SGTC_1043 0916-0009 19.3 µM 1.55541403343357 0.0446470578787222 no 230 0.0599237470022401 483 3101130 SGTC_1246 0422-0085 105 µM 1.54879607692763 0.0453347407499834 no 231 0.0607153744630026 439 264295 SGTC_3328 9140624 29.0385 µM 1.54643494634883 0.0455821421999659 no 232 0.0609997798806258 398 4904392 SGTC_438 sphingosine 6.67 µM 1.54045909672958 0.0462131494384576 no 233 0.0617242429102959 325 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_598 3937-0236 20.2 µM 1.53661141774027 0.0466231361853499 no 234 0.062194247437398 456 1379313 SGTC_3 0833-0587 95.581 µM 1.53482883921699 0.0468140643742098 no 235 0.0624129384197324 374 5382644 SGTC_1883 5-benzylidenerhodanine 20 µM 1.53407574225105 0.0468949152142332 no 236 0.0625055101285707 482 1273210 SGTC_961 1252-1571 372 µM 1.52581471763662 0.0477891720166663 no 237 0.0635280071552463 418 6813498 SGTC_2763 lisinopril 49.32 µM 1.52408176998683 0.0479784854172175 no 238 0.0637441430043234 353 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2125 5246583 200 µM 1.51693482049051 0.048765594784197 no 239 0.0646415705802982 490 835267 SGTC_2791 5663188 71.43 µM 1.51347273768325 0.049150574823427 no 240 0.0650798104999798 399 54690634 SGTC_2866 9034245 58.44 µM 1.51337733481809 0.0491612177911933 no 241 0.0650919194204289 352 6462273 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.50671418708648 0.0499091109452755 no 242 0.0659419667410587 411 6708760 SGTC_2130 NSC 7 2.4545 µM 1.50649200587437 0.049934204756361 no 243 0.0659704588834565 442 21448 SGTC_2750 bromebric acid 70.15 µM 1.5056525815438 0.0500291026874234 no 244 0.066078191346875 484 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_268 camptothecin 39.6153 µM 1.50517351955773 0.0500833256427663 no 245 0.0661397356473731 538 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2536 dehydroabietamide 32.04 µM 1.50158648263186 0.0504908171715357 no 246 0.0666019682347956 460 3983547 SGTC_2068 5226020 147 µM 1.49813790363472 0.0508850659470094 no 247 0.0670487125043951 471 1810509 SGTC_871 0574-0004 149 µM 1.4942878801822 0.0513280998882779 no 248 0.0675501957717606 476 9551173 SGTC_390 dec-rvkr-cmk 16.7 µM 1.49389245191894 0.0513737762515229 no 249 0.0676018658135477 437 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1490 4089-0339 670 nM 1.49157685034294 0.0516419033501459 no 250 0.0679050553566335 355 742542 SGTC_201 4262-0159 12.803 µM 1.47943409542486 0.0530661922434758 no 251 0.0695121666090864 366 1341029 SGTC_2384 9036245 200 µM 1.47778528551449 0.0532619692160293 no 252 0.0697326290474926 447 6462766 SGTC_1915 st067105 30.6 µM 1.47242618422635 0.0539022570342271 no 253 0.0704529133360904 452 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1414 3917-0015 5.4 µM 1.47177451024647 0.053980530753975 no 254 0.0705408895232408 392 6618702 SGTC_1882 5615643 20 µM 1.46799076399655 0.0544367826480679 no 255 0.0710533658636431 387 2253075 SGTC_2089 5281248 129.67 µM 1.46734161209261 0.0545153643829848 no 256 0.0711415746181095 449 2737878 SGTC_398 bronopol 33.3 µM 1.46690815242604 0.0545678858755546 no 257 0.0712005212515292 436 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_220 paclitaxel 373.376 µM 1.46388424305056 0.0549354013777843 no 258 0.0716127896806556 363 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2905 7799065 20.05 µM 1.46284927786941 0.0550616358377488 no 259 0.071754312849863 394 1296806 SGTC_1699 st031318 29.054 µM 1.45694434708762 0.0557862482657255 no 260 0.0725658715871311 439 5340658 SGTC_1898 st060199 18.6 µM 1.45600187704126 0.0559025948703931 no 261 0.0726960503601693 424 688866 SGTC_2837 9008476 45.46 µM 1.45574360346471 0.0559345117747595 no 262 0.0727317556249002 474 2992805 SGTC_158 k038-0087 26.446 µM 1.45405428979268 0.0561436282350071 no 263 0.072965627574428 578 X158 SGTC_708 3448-5400 146 µM 1.43606891772074 0.0584084063299312 no 264 0.0754913657803773 489 3462195 SGTC_2861 9024595 19.48 µM 1.43462346388549 0.0585934935410769 no 265 0.075697212299735 323 16482810 SGTC_843 0310-0051 143 µM 1.42617467341007 0.0596845698274671 no 266 0.0769089641495355 453 2065037 SGTC_863 0466-0191 129 µM 1.42541824327697 0.0597830265152938 no 267 0.0770181688268133 529 765160 YPR165W RHO1 SGTC_1270 0831-1170 17.3 µM 1.42460120409517 0.0598895149478009 no 268 0.0771362558917708 505 6764716 SGTC_1035 k081-0041 55.2 µM 1.40716048919724 0.0621982597398446 no 269 0.0796899023566146 506 731709 SGTC_2699 st077704 54.6 µM 1.40649487746762 0.0622877276807338 no 270 0.0797886123243483 477 645852 SGTC_3183 9108214 49.47 µM 1.40585300488901 0.0623740997679859 no 271 0.0798838893507449 322 4974831 SGTC_372 0155-0182 15.9 µM 1.40273160083163 0.062795456325543 no 272 0.0803484451243706 507 771486 SGTC_67 0335-0847 266 µM 1.40224216644844 0.0628617254804785 no 273 0.0804214719721556 637 4552207 YOR254C SEC63 SGTC_2767 sibutramine 71.45 µM 1.39879740773004 0.0633296864333483 no 274 0.0809368719462461 483 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2886 9058944 51.95 µM 1.39353163220262 0.0640502632701859 no 275 0.0817295432135039 284 4949929 SGTC_3042 9091578 49.47 µM 1.3924575883532 0.0641980167782768 no 276 0.0818919380483744 422 25236497 SGTC_802 4112-3352 742 µM 1.39002295348702 0.0645339242248043 no 277 0.0822609536869571 541 704594 SGTC_3214 9129694 49.47 µM 1.38899644421446 0.0646759606142631 no 278 0.0824169156538661 453 17158655 SGTC_364 0083-0097 67.7 µM 1.38667847673936 0.0649975869786667 no 279 0.0827699132538946 486 5207356 SGTC_686 1319-0111 510 µM 1.38486304155311 0.0652503509857007 no 280 0.0830471749425849 532 4562600 SGTC_739 1486-1183 203 µM 1.38258994980547 0.0655679092101902 no 281 0.0833953162118115 506 4346692 SGTC_3238 9133470 49.47 µM 1.38067440632025 0.0658364461367799 no 282 0.0836895470236664 469 3534688 SGTC_2999 9069765 71.4286 µM 1.37485902420032 0.0666569186134335 no 283 0.0845875774474925 522 2097066 SGTC_2311 7694451 200 µM 1.37341041155649 0.0668625244815166 no 284 0.0848123974319851 490 2163142 SGTC_543 3844-1095 191 µM 1.36912787973192 0.0674732266369203 no 285 0.0854796524215984 534 4230703 SGTC_2426 5582046 32.21 µM 1.36459864210892 0.0681237908408222 no 286 0.0861896159009147 516 2251934 SGTC_705 1124-0212 310 µM 1.35807811081259 0.0690688673185064 no 287 0.0872194500310073 525 9554485 SGTC_1815 st051655 58.2 µM 1.3575142194445 0.0691510692682726 no 288 0.0873089392256843 454 5984156 SGTC_2170 morpholine 200 µM 1.35744683818308 0.0691608968935963 no 289 0.0873196371713885 485 121171 Reacts with secondary amines. SGTC_1478 0453-0656 35.7 µM 1.3559182054837 0.069384138785968 no 290 0.0875625971591609 505 5258496 SGTC_2523 spermine 47.74 µM 1.35311248818819 0.0697953301445217 no 291 0.0880098483271004 485 1103 A DNA binding polyamine. SGTC_3346 9158254 43.5805 µM 1.35278200845956 0.0698438867509788 no 292 0.0880626410661977 520 17639500 SGTC_1101 ebselen 5.29 µM 1.34963487542652 0.0703075910578415 no 293 0.0885665657650784 540 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2828 7998861 71.43 µM 1.34784653633889 0.0705721410082648 no 294 0.0888538733637429 417 2988188 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.34607862522361 0.070834420437905 no 295 0.0891385806092563 544 6728940 SGTC_3347 9188721 44.724 µM 1.34601123307627 0.0708444332347123 no 296 0.0891494469661673 473 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1498 4478-3555 97.6 µM 1.34225264156275 0.0714045896680202 no 297 0.0897570466059738 447 3437919 SGTC_2449 5812982 45.77 µM 1.33873414560761 0.0719320384981922 no 298 0.0903286180578368 478 776185 SGTC_550 4123-0385 25.7 µM 1.33574924908298 0.0723818347037007 no 299 0.0908156230826695 517 5731123 SGTC_2144 5628481 200 µM 1.33343781271118 0.072731624807308 no 300 0.0911940852488307 466 2818399 SGTC_885 0865-0106 16.8 µM 1.33250350287045 0.0728733808785267 no 301 0.0913473955877887 521 2793380 SGTC_1795 st049545 62.3 µM 1.33133433546683 0.0730510680128464 no 302 0.0915395126068965 500 5291882 SGTC_1382 3002-2117 298 µM 1.32914893777168 0.073384088143732 no 303 0.0918994187617536 544 1497314 SGTC_2899 9053889 58.44 µM 1.32656521655848 0.0737793029733991 no 304 0.0923262742153905 480 6470052 SGTC_3088 9117578 49.47 µM 1.32532514946655 0.0739695647091108 no 305 0.0925316655204228 502 678341 SGTC_3087 9117406 49.47 µM 1.32377732070504 0.0742075716041482 no 306 0.0927885051764754 506 42546093 SGTC_2555 cholic acid 100 µM 1.32277723399732 0.0743616639370292 no 307 0.0929547351321111 526 6708657 Influences liver metabolism. SGTC_1555 citronellol 128 µM 1.32245814917078 0.0744108795754965 no 308 0.0930078182884922 490 8842 A terpine precursor. SGTC_2954 9074818 52.69 µM 1.32107091104862 0.0746251362878228 no 309 0.0932388606038672 530 16648742 SGTC_665 3914-0008 307 µM 1.31975072594746 0.0748294737136688 no 310 0.0934591289129254 525 1069549 SGTC_248 streptozotocin 5.23457 mM 1.31862917813952 0.0750034013082117 no 311 0.0936465570348959 541 5300 DNA alkylating agent. SGTC_2381 9035592 200 µM 1.31749868504531 0.0751790279801957 no 312 0.0938357607751605 449 4749657 SGTC_98 0074-0023 107.663 µM 1.31323874975199 0.0758436439323028 no 313 0.0945512552217206 567 3563821 SGTC_887 0885-0007 9.62 µM 1.31208657102353 0.0760241682199111 no 314 0.0947454632416469 574 5719458 SGTC_3262 9137218 49.47 µM 1.31154452108091 0.0761092101122731 no 315 0.0948369312800722 355 17650664 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.31128057986819 0.0761506458984181 no 316 0.0948814935007203 552 5282309 SGTC_1903 st060211 78.3 µM 1.3099209916398 0.0763643579558579 no 317 0.095111282495054 574 688960 SGTC_1088 bifonazole 369 nM 1.3048936750649 0.0771585606865855 no 318 0.0959645276272306 524 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1351 1496-0003 46.5 µM 1.30416369370152 0.077274401225549 no 319 0.0960888879203719 560 3891978 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.30080556535652 0.0778090041570176 no 320 0.0966625082590141 582 2724 A muscle relaxant with antifungal properties. SGTC_642 0335-0876 158 µM 1.299139481593 0.078075278824952 no 321 0.0969480329090883 547 6812350 SGTC_1177 0983-0204 23.6 µM 1.2967013564172 0.0784661869215434 no 322 0.097366981233556 596 766818 SGTC_1011 4112-3381 17.4 µM 1.29547257929224 0.0786637600019757 no 323 0.0975786273339288 566 2877139 SGTC_1830 st055982 50.3 µM 1.29247166797342 0.079147856110636 no 324 0.0980969257068485 561 455313 An antimicrobial agent. SGTC_1834 st055981 52.8 µM 1.28643601723754 0.0801283317002158 no 325 0.0991454676172141 566 471719 YDL150W RPC53 SGTC_2821 7996764 71.43 µM 1.28175175356501 0.0808955848341988 no 326 0.0999648718428593 586 2987135 SGTC_1649 st011737 51.3 µM 1.28014096031264 0.081160700227611 no 327 0.100247782681833 546 1761035 SGTC_1614 st002383 48.6 µM 1.27983646705626 0.0812108894110388 no 328 0.100301327812173 567 1947235 SGTC_1219 1469-0211 33.1 µM 1.27975614391532 0.0812241328608957 no 329 0.100315456112986 533 6822282 SGTC_2986 9022445 71.43 µM 1.27149998632638 0.0825940931921488 no 330 0.101775416151288 554 6459286 SGTC_2491 paeonol 100 µM 1.26993559075042 0.0828556250439544 no 331 0.10205378707863 506 11092 Increases levels of cortical cytochrome oxidase. SGTC_547 1120-0019 610 nM 1.26990557071446 0.082860649806308 no 332 0.102059134301574 576 3676939 SGTC_432 NS 1619 61.3 µM 1.26848788047113 0.0830982043536348 no 333 0.102311888025362 522 4552 A K+/calcium channel activator. SGTC_611 3453-1652 23.7 µM 1.26753402460554 0.0832583247206662 no 334 0.102482202772284 598 1560575 SGTC_2351 9026858 72.31 µM 1.26692489854449 0.0833606978247486 no 335 0.102591072440799 523 1409300 SGTC_2474 5321570 43.32 µM 1.26540582720161 0.0836164135647618 no 336 0.102862943696664 538 2841384 SGTC_2800 7887935 81.82 µM 1.26162671344466 0.0842551342481218 no 337 0.103541569546384 560 2961002 SGTC_3278 9139605 49.47 µM 1.26063006671804 0.0844241894857254 no 338 0.103721080360859 564 7958859 SGTC_2583 asiatic acid 100 µM 1.25958576698999 0.0846016007344857 no 339 0.103909416310733 542 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_876 0720-0963 56.8 µM 1.25943186955362 0.0846277692821714 no 340 0.10393719215186 615 765861 SGTC_104 0074-0074 590.992 µM 1.25918722191006 0.0846693813892949 no 341 0.103981357927751 426 3943124 SGTC_1694 st024011 44.9 µM 1.25900566631227 0.0847002720913012 no 342 0.104014142612257 622 2787533 SGTC_1986 st071812 45 µM 1.25790172511082 0.0848882836721429 no 343 0.104213649868971 524 11838594 SGTC_1571 st070080 73.4 µM 1.25771008179948 0.0849209541799765 no 344 0.104248312407174 572 4315245 SGTC_2406 ethylparaben 405.7 µM 1.25704346739097 0.0850346690880354 no 345 0.104368948085592 498 8434 A possible steroid mimic. SGTC_893 0958-0369 48.9 µM 1.25696917916621 0.0850473486640566 no 346 0.104382398117458 612 6819948 SGTC_2429 5902844 64.44 µM 1.25530857358287 0.0853311522021116 no 347 0.104683382000585 603 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1100 amiodarone 5.07 µM 1.25464253033589 0.0854451805460679 no 348 0.104804278434769 604 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1401 3807-4679 7.6 µM 1.25244233243287 0.0858226713884924 no 349 0.105204364569048 544 3291456 SGTC_585 0kpi-0023 191 µM 1.24595267306648 0.0869433808270153 no 350 0.106390885328762 541 64601 SGTC_2965 9082772 38.63 µM 1.24520099320259 0.0870738928343922 no 351 0.106528938812937 615 16459634 SGTC_2080 5212524 12.4 µM 1.2408195815573 0.0878375380625751 no 352 0.10733620290019 565 260183 SGTC_2368 9071271 200 µM 1.23990500446201 0.0879975698752726 no 353 0.107505266325819 570 27209959 SGTC_3081 9117243 49.47 µM 1.23828612449112 0.0882813727652288 no 354 0.10780499343644 560 45595589 SGTC_1710 st031758 61.5 µM 1.23824651278817 0.0882883255605187 no 355 0.107812334871477 556 5394341 SGTC_329 k048-0121 21.3 µM 1.23678592440935 0.0885449785709599 no 356 0.108083284505446 560 6832902 SGTC_381 3461-2219 42.7 µM 1.23616149933441 0.0886548713112666 no 357 0.108199269311659 642 2883159 SGTC_1309 pyrazolanthrone 13.4 µM 1.23460601474826 0.0889290631284198 no 358 0.108488584703208 643 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2119 5528445 120.635 µM 1.23398667081657 0.0890384130439135 no 359 0.108603935568649 578 791935 SGTC_1375 2910-0797 186 µM 1.23322333123718 0.0891733241433712 no 360 0.10874622650664 595 742508 SGTC_2350 9023895 38.85 µM 1.23149947577894 0.0894785544376281 no 361 0.1090680563031 589 2997209 SGTC_1579 chlormadinone acetate 49.4 µM 1.23086486106292 0.0895911164214631 no 362 0.109186705922825 614 45114258 A steroidal progestin. SGTC_1534 6-azauridine 81.6 µM 1.22794604487746 0.0901101846371925 no 363 0.10973361149643 658 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3007 9078383 71.4286 µM 1.22227791892228 0.0911245533078248 no 364 0.11080127326786 608 6496995 SGTC_912 3474-0017 2.18 µM 1.22197196561265 0.0911795466741564 no 365 0.110859114350115 623 3360550 SGTC_1813 st051246 8.6015 µM 1.21819477263803 0.0918605042446951 no 366 0.111574982825786 565 5291959 SGTC_3254 9136651 49.47 µM 1.21721543368717 0.0920376742020816 no 367 0.111761129778676 631 16454030 SGTC_1312 1218-2183 165 µM 1.21046241392386 0.0932662397935467 no 368 0.113050752455547 639 6744073 SGTC_2203 7227154 166.4 µM 1.20961928940542 0.0934204748948542 no 369 0.113212506462406 569 896304 SGTC_29 0299-0004 12.984 µM 1.20942376148666 0.093456270255454 no 370 0.113250042200067 509 16871 A napthoquinone isolated from Swertia calycina. SGTC_88 0180-0332 8.668 µM 1.20615806973996 0.0940556198879789 no 371 0.113878273938906 619 3101745 SGTC_1398 3558-0053 112 µM 1.20478696111668 0.0943081018815026 no 372 0.114142777420787 541 4532369 SGTC_1094 duloxetine 25.4 µM 1.2008685997177 0.0950324011873827 no 373 0.114901088163831 608 60834 A selective serotonin reuptake inhibitor. SGTC_2646 retinol 96.75 µM 1.2007866884987 0.0950475858726289 no 374 0.114916978385284 603 445354 A vitamin A analog and teratogen. SGTC_3185 9108267 49.47 µM 1.20039631131072 0.0951199784719527 no 375 0.114992730390474 616 4910486 SGTC_1008 4106-0037 6 µM 1.19816866403863 0.0955338565398553 no 376 0.115425680970401 587 2905394 SGTC_3041 9091929 49.47 µM 1.19767107254559 0.0956264856536902 no 377 0.115522547583664 643 25236887 SGTC_1561 5-methoxyflavone 52.9 µM 1.19683821453587 0.0957816741374122 no 378 0.115684810069949 549 94525 SGTC_1428 4049-0204 61.7 µM 1.19449291903245 0.0962196741043279 no 379 0.116142604471609 634 X1428 SGTC_3160 9100216 49.47 µM 1.19202656227818 0.0966818694590838 no 380 0.116625415104498 633 17191039 SGTC_262 fenpropimorph 62.5 µM 1.18773622598486 0.0974897606097049 no 381 0.117468673406013 581 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3277 9138724 49.47 µM 1.18206936940549 0.0985644315241613 no 382 0.118589088522323 515 15943418 SGTC_2367 9070478 135.38 µM 1.18083810367229 0.0987990730865733 no 383 0.118833521951039 655 572802 SGTC_715 0868-0130 184 µM 1.17975593811316 0.0990056380003201 no 384 0.119048649352388 598 2876258 SGTC_1772 st048439 82.2 µM 1.17964011285289 0.0990277655516025 no 385 0.119071690932845 646 2927068 YDL195W SEC31 SGTC_2084 5306078 60.6385 µM 1.17865627654948 0.0992158660131048 no 386 0.11926753637249 620 679340 SGTC_2294 7971431 200 µM 1.17841990793513 0.0992610964200431 no 387 0.1193146224782 571 5741572 SGTC_746 1095-0025 46.6 µM 1.17642491380122 0.0996434500393389 no 388 0.119712560453816 685 6749286 SGTC_137 0438-0332 85.389 µM 1.17564996952079 0.0997922630022213 no 389 0.119867389344307 751 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_847 0342-0274 5.54 µM 1.17339620908476 0.10022597637028 no 390 0.120318478366505 660 18097 SGTC_2462 5162487 171.77 µM 1.1723049962868 0.100436462911984 no 391 0.120537313193949 651 2259986 SGTC_1260 0700-1617 7.75 µM 1.16917730405615 0.10104155749915 no 392 0.121166101662799 668 2853078 SGTC_632 0781-2353 4.65 µM 1.16774735838992 0.101319083350954 no 393 0.121454343867447 679 6811515 YHR007C ERG11 SGTC_578 3460-0051 92 µM 1.16678591421862 0.101505993748556 no 394 0.121648418401187 723 2876744 SGTC_1392 3455-1037 33.9 µM 1.16026198861025 0.102780919879928 no 395 0.122971077770216 651 981132 SGTC_1451 4152-0210 104 µM 1.15932749194383 0.102964490793976 no 396 0.123161359853347 669 659563 SGTC_1272 0839-0021 27 µM 1.15840528801045 0.103145880330519 no 397 0.123349341100567 678 5027250 SGTC_169 k015-0017 16.025 µM 1.15189756842171 0.104432492483528 no 398 0.124681583779667 602 1840002 SGTC_3289 9119912 71.43 µM 1.14571642104706 0.105665270163827 no 399 0.125956253540332 651 17014829 SGTC_3351 9150312 21.596 µM 1.14422786909442 0.10596371498132 no 400 0.126264574085094 675 4904905 SGTC_2771 fluoxetine 41.05 µM 1.14009510368508 0.106795499263547 no 401 0.127123340798253 637 3386 A selective serotonin reuptake inhibitor. SGTC_1929 genistein trimethyl ether 50.5 µM 1.13547388255199 0.107731160820625 no 402 0.12808840942651 669 136420 SGTC_2667 digitoxin 100 µM 1.13487448261627 0.107852953036556 no 403 0.128213956441062 584 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2083 5306046 65.942 µM 1.1348113031876 0.107865796254718 no 404 0.128227194633569 671 539837 SGTC_2099 5377090 177.372 µM 1.13471890448966 0.107884581197354 no 405 0.128246556944352 666 2243829 SGTC_791 1348-1292 225 µM 1.13415297571874 0.107999687685693 no 406 0.128365192619476 764 5437054 SGTC_3162 9099653 49.47 µM 1.13195267736422 0.108448055296322 no 407 0.128827165142814 620 25237511 SGTC_1251 0490-5699 265 µM 1.13104085885617 0.108634253827725 no 408 0.129018947270163 729 3883818 SGTC_1477 0139-0234 16 µM 1.12712332623096 0.109436852401475 no 409 0.129845171134458 686 620880 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.12653807849169 0.109557118846675 no 410 0.129968916134666 729 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2789 5281112 71.43 µM 1.12559802129471 0.109750496047 no 411 0.130167853011273 672 765948 SGTC_1938 st074717 56.4 µM 1.12477594485866 0.109919804386865 no 412 0.130341995171681 614 17250979 SGTC_2982 9019404 25.97 µM 1.1234632321494 0.110190548748451 no 413 0.130620403851818 562 22333232 SGTC_2870 9038528 12.99 µM 1.12297276595701 0.110291829061166 no 414 0.130724530557824 615 6463316 SGTC_2468 5987765 72.9 µM 1.12151110800067 0.1105940544631 no 415 0.131035182977103 713 26772094 SGTC_2529 gangaleoidin 93.61 µM 1.12082580122198 0.110735958807169 no 416 0.131181009644984 686 4565183 SGTC_2997 9067075 71.4286 µM 1.12003859811128 0.110899123467962 no 417 0.131348657153855 716 27209819 SGTC_917 harmaline 728.087 nM 1.11788047324627 0.11134732405963 no 418 0.131809022912058 693 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3322 9139058 2.11 µM 1.11749006428743 0.111428542714781 no 419 0.131892422727004 710 4908926 YPR165W RHO1 SGTC_22 0964-0034 14.468 µM 1.116205548208 0.111696066002176 no 420 0.132167080073267 721 138402 SGTC_338 4055-0136 114 µM 1.11488705089112 0.111971144020932 no 421 0.132449413202221 685 2900563 SGTC_468 gf-109203x 121 µM 1.11198609305744 0.112578075165706 no 422 0.133072064906234 561 2396 A protein kinase C inhibitor. SGTC_247 mechlorethamine 29.705 µM 1.1114322150961 0.112694222772215 no 423 0.133191176072135 637 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1853 st056710 91.2 µM 1.11105248135399 0.112773901953225 no 424 0.133272879995182 717 269167 SGTC_116 0155-0182 31.788 µM 1.10911350253919 0.113181383171536 no 425 0.133690610336558 819 771486 SGTC_506 n9-isopropylolomoucine 153 µM 1.10581712355417 0.113876534368542 no 426 0.134402840930784 708 6610355 SGTC_1029 k015-0030 64.7 µM 1.10563098522931 0.113915878381115 no 427 0.134443136386623 686 2208316 SGTC_204 PMA1.184 62.41 µM 1.104730813197 0.114106284208691 no 428 0.134638123789598 755 2252213 YGL008C PMA1 SGTC_1220 1838-0075 193 µM 1.10361906120156 0.114341756510981 no 429 0.134879209558169 716 5529645 SGTC_1713 st033146 12.748 µM 1.10305059545917 0.114462292801772 no 430 0.135002596915041 716 674619 SGTC_517 1365-0151 113 µM 1.10171938589685 0.11474491355629 no 431 0.135291843165241 701 768657 SGTC_1222 0366-0074 1.18 µM 1.09944772431626 0.115228341653638 no 432 0.135786411953402 750 286520 SGTC_2931 9014674 55.67 µM 1.09898583064947 0.115326813258842 no 433 0.13588712319347 676 2996810 SGTC_848 0368-0089 85.6 µM 1.09887173165106 0.115351147356131 no 434 0.135912009201337 731 762535 SGTC_2920 7982904 15.77 µM 1.09872442125376 0.115382569904695 no 435 0.135944143526145 628 6456808 SGTC_2034 5197015 53.07 µM 1.09696458504831 0.115758428292383 no 436 0.136328436892329 714 780676 SGTC_490 phenamil 164 µM 1.09463161425744 0.116258033647619 no 437 0.136839029755148 608 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2478 5763493 32.33 µM 1.09301471148905 0.116605189619016 no 438 0.13719367027606 742 1365576 YLR208W SEC13 SGTC_2407 paclitaxel 400 µM 1.09240835935188 0.116735565368907 no 439 0.137326825177325 743 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_891 0929-0073 133 µM 1.09062756164421 0.117119063740826 no 440 0.137718398371523 721 5603632 SGTC_1927 st060202 13.8 µM 1.08900981860631 0.117468220960106 no 441 0.138074777940891 706 688887 SGTC_828 2074-0507 139 µM 1.0845857002347 0.118426839587937 no 442 0.139052595618661 738 X828 SGTC_1127 asiatic acid 681.4 nM 1.08269162750175 0.118838933427987 no 443 0.139472660757073 698 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_42 0133-0086 60.653 µM 1.08260093249814 0.118858691339711 no 444 0.139492796615997 641 162923 Model of phenazepam hydroxylation. SGTC_2138 5575593 77.673 µM 1.08164396405882 0.119067308371033 no 445 0.139705380655232 688 762213 SGTC_857 0438-0306 1.35 µM 1.08151253095355 0.119095980679819 no 446 0.139734594821306 717 4686136 SGTC_2831 7999036 19.48 µM 1.07917127093464 0.119607546659998 no 447 0.140255692093164 763 2988270 SGTC_2891 9063876 19.48 µM 1.07845508163981 0.119764343348664 no 448 0.140415358558198 657 6472478 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.07662980868527 0.120164609094021 no 449 0.140822840838396 530 4000243 SGTC_1097 itavastatin 7.23 µM 1.07486836654407 0.120551770187048 no 450 0.141216833225991 753 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_454 lyso-paf C-16 6.67 µM 1.07482766090655 0.120560727567996 no 451 0.141225946927463 690 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1024 4507-0395 26 µM 1.07111990164856 0.121378595888831 no 452 0.142057760367822 694 4201836 SGTC_2197 6588183 93.1375 µM 1.06746891836763 0.122187744620152 no 453 0.14288007088441 693 884136 SGTC_1562 morin hydrate 59.1 µM 1.06444992219807 0.122859683902644 no 454 0.143562464361005 712 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2239 6685329 187.64 µM 1.06203847046333 0.123398260040351 no 455 0.144109110462697 736 805680 SGTC_3061 glucosamine 200 µM 1.06085326639573 0.123663570093311 no 456 0.144378295242107 714 91431 and experimental redox chemotherapeutic SGTC_458 nppb 133 µM 1.05902304253171 0.12407405316445 no 457 0.144794642891452 717 4549 A chloride channel blocker. SGTC_81 0411-0046 9.971 µM 1.05673768071313 0.124587951884772 no 458 0.145315661469141 685 12925265 SGTC_1723 st034307 2.5525 µM 1.05623090306183 0.124702109893731 no 459 0.14543136767709 732 867466 SGTC_1634 st006576 41 µM 1.04915030225862 0.126304753153322 no 460 0.147054473849184 749 3915356 SGTC_3326 9140064 16.379 µM 1.04410592650482 0.12745523111295 no 461 0.148218192107158 738 1868434 SGTC_1361 1608-0041 5.61 µM 1.04296138568209 0.12771727933015 no 462 0.148483088567334 776 X1361 SGTC_2246 7293507 91.5585 µM 1.04101530206973 0.128163703937042 no 463 0.148934223217483 788 887656 SGTC_2748 diazoxide 86.69 µM 1.04002653814655 0.128390937558161 no 464 0.149163785684098 698 3019 A potassium channel activatior. SGTC_792 4534-1957 155 µM 1.03984736819601 0.128432143567385 no 465 0.149205409055971 760 1717904 SGTC_270 tamoxifen 5.46 µM 1.03922216575818 0.1285760012866 no 466 0.149350711980814 829 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_593 1203-0218 61.7 µM 1.03693122244164 0.129104097832783 no 467 0.149883955824664 798 3666956 SGTC_27 0485-0001 32.618 µM 1.03640286810683 0.129226104481962 no 468 0.15000711644176 698 2054479 SGTC_1086 cerivastatin 2.18 µM 1.03356088482871 0.129883741273428 no 469 0.150670746712515 737 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_345 1362-0200 395 µM 1.0327398632433 0.130074156838677 no 470 0.150862826533842 721 1419823 SGTC_3229 9132204 49.47 µM 1.031854101928 0.130279803738777 no 471 0.151070235070914 752 17682924 SGTC_1683 st010134 710 nM 1.03020447987943 0.130663395220027 no 472 0.151457013600318 752 3818134 SGTC_1141 3253-0389 52.6 µM 1.03003086135809 0.130703812615547 no 473 0.151497759317953 769 5402031 SGTC_2279 7948423 32.93 µM 1.0297011736564 0.130780585807183 no 474 0.151575152238293 715 1247112 SGTC_394 menadione 8.33 µM 1.02888983858411 0.130969651213577 no 475 0.151765721932626 788 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3009 9080819 71.4286 µM 1.02820898301937 0.131128456657732 no 476 0.151925766882653 769 17027216 SGTC_1757 st041620 31.8375 µM 1.02784967001784 0.131212317841732 no 477 0.152010273783528 774 5289815 SGTC_349 k015-0014 24 µM 1.02679042009373 0.131459755017534 no 478 0.152259580654138 721 2196908 SGTC_1808 st050063 61.5 µM 1.02460129812906 0.131972146735064 no 479 0.152775675878882 773 4011993 SGTC_2805 7950783 58.44 µM 1.02376741649794 0.132167689093477 no 480 0.152972571969838 814 1178958 YDL195W SEC31 SGTC_160 3453-0671 289.699 µM 1.01804652025236 0.133514605342205 no 481 0.154327924356911 849 5322268 SGTC_2146 5545642 200 µM 1.01707374552405 0.133744569222349 no 482 0.154559174429143 791 825326 SGTC_2215 7188065 200 µM 1.01615253471055 0.133962594284462 no 483 0.15477837764723 747 940217 SGTC_1143 3454-2408 5.08 µM 1.0137125686787 0.134541246274488 no 484 0.155359962469187 754 X1143 SGTC_2174 5790901 200 µM 1.01211367274546 0.134921362880722 no 485 0.15574185284871 767 786020 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.0079118883926 0.135923791448154 no 486 0.156748381924934 655 88881 An O-methylated flavonoid and antioxidant. SGTC_1431 4049-0260 9.09 µM 1.00782864395902 0.135943702628418 no 487 0.156768366115571 811 3854841 SGTC_1513 0337-0559 19 µM 1.00665422094947 0.136224824914131 no 488 0.157050484297012 717 775073 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.00613331061583 0.136349642777268 no 489 0.157175723456302 854 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_311 1315-0136 58 µM 1.00212008044663 0.137313895774165 no 490 0.158142800327221 800 6759207 SGTC_3252 9135871 49.47 µM 1.00094502653822 0.137597103528318 no 491 0.158426693224319 795 17682838 SGTC_132 0417-1715 25.805 µM 1.00079706999818 0.13763279178389 no 492 0.158462463190987 837 6769098 SGTC_1488 4013-0813 75.9 µM 0.999499138797291 0.137946133569702 no 493 0.158776478030182 766 2910057 SGTC_2378 9074213 121.43 µM 0.997778309158038 0.138362319681997 no 494 0.159193435246536 802 657714 SGTC_960 1222-0186 7.7 µM 0.996685717828644 0.138627008852658 no 495 0.159458542146922 810 3126296 SGTC_1134 3477-0009 42.5 µM 0.993345689318382 0.13943829612682 no 496 0.160270759482446 847 3973534 SGTC_2580 diallyl disulphide 81.36 µM 0.992199127694004 0.139717537151983 no 497 0.16055019897633 765 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_910 3454-3003 490 µM 0.991683778572471 0.139843172371005 no 498 0.160675903250791 831 820824 SGTC_2341 7987486 176.74 µM 0.988508398388871 0.14061898156915 no 499 0.161451861699543 846 1258686 SGTC_2724 maprotiline 69.64 µM 0.988309747211526 0.140667612948224 no 500 0.161500486593842 832 4011 A tricyclic antidepressant. SGTC_1998 st075797 76.8 µM 0.988211122486776 0.140691761300379 no 501 0.161524631033496 902 24208315 SGTC_691 1548-0686 185 µM 0.988172356133693 0.140701254046843 no 502 0.161534122116169 806 46495133 SGTC_1305 1181-0477 144 µM 0.987064374658723 0.140972750063905 no 503 0.161805540530776 810 6252086 SGTC_2894 9048625 32.47 µM 0.98512229701683 0.14144948695052 no 504 0.162282001142197 812 4092861 SGTC_1902 st060212 70.5 µM 0.984643880690565 0.141567095049839 no 505 0.162399513728582 835 688944 SGTC_2320 7373003 200 µM 0.979626220101984 0.142804567327876 no 506 0.163635328650051 796 5415828 SGTC_289 k017-0060 526 µM 0.97943292937418 0.142852383146805 no 507 0.163683056629157 787 5512909 SGTC_184 1494-0393 24.714 µM 0.978541852493154 0.143072955632717 no 508 0.163903201100684 811 3090647 SGTC_2372 9071633 200 µM 0.978457546187597 0.14309383628069 no 509 0.163924039289357 897 21321366 SGTC_797 k781-0471 270 µM 0.975108772506697 0.143924912359362 no 510 0.164753153792461 839 23738129 SGTC_3072 9116419 49.47 µM 0.974456939380323 0.144087057698785 no 511 0.164914854840156 737 17170162 SGTC_213 1246-0773 967 nM 0.974387466976588 0.144104346417313 no 512 0.164932095003794 852 6251622 SGTC_736 0958-0254 92.6 µM 0.973221235688468 0.144394780482757 no 513 0.165221679381327 860 6812352 SGTC_1204 4049-0315 18.3 µM 0.970168131372406 0.145156981751521 no 514 0.165981346493213 813 588402 SGTC_1138 3761-0006 1.03 µM 0.96748626712984 0.145828733536175 no 515 0.166650501559857 845 12061087 SGTC_1373 2887-0003 58.5 µM 0.964779851272898 0.146508749931995 no 516 0.167327544961025 796 776948 SGTC_2928 9011484 9.79 µM 0.964405994636374 0.1466028525233 no 517 0.167421208979898 779 2994751 SGTC_2896 9052656 71.43 µM 0.964158076222413 0.146665277858926 no 518 0.167483339743896 899 6469436 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.963781791376302 0.146760059669334 no 519 0.167577668763162 758 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_595 3909-8003 73.7 µM 0.963643219507085 0.146794974675282 no 520 0.167612415291829 834 699517 SGTC_2493 resveratrol 26.09 µM 0.959936663339631 0.147730958397385 no 521 0.168543546263553 783 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_566 0958-0068 16.5 µM 0.959573674144363 0.147822835222475 no 522 0.168634911909521 779 6815365 SGTC_1189 1431-2119 7.28 µM 0.958746782495431 0.148032274019792 no 523 0.168843162259611 872 3107275 SGTC_3263 9137018 49.47 µM 0.957045178412512 0.148463888457885 no 524 0.169272226119546 790 43844957 SGTC_821 1114-0266 29.2 µM 0.957016868192676 0.148471076497815 no 525 0.169279370528893 821 3123235 SGTC_1223 0764-0573 147 µM 0.954427671500517 0.149129464451174 no 526 0.169933602420664 878 1609797 SGTC_1525 8-methoxypsoralen 92.5 µM 0.952526411122822 0.149614161892851 no 527 0.170415039006295 919 4114 Related to psoralen; DNA damaging agent. SGTC_196 k015-0023 18.111 µM 0.951998635083176 0.149748896567726 no 528 0.170548837051218 876 5211998 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.951494171364621 0.149877755531925 no 529 0.170676787974601 794 77254 SGTC_862 0452-0056 10.2 µM 0.950251993490839 0.15019536953398 no 530 0.170992112743172 845 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2352 9027995 87.8 µM 0.949996770996918 0.15026068320666 no 531 0.171056946667216 810 2997347 SGTC_3095 9117207 49.47 µM 0.948192827165804 0.15072286789539 no 532 0.171515649028293 808 17015229 SGTC_1084 voriconazole 435 nM 0.947981868065225 0.150776979042675 no 533 0.171569342473765 880 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1884 5633444 25 µM 0.946678663828988 0.151111538493477 no 534 0.171901272921128 867 5724239 SGTC_350 k064-0020 19.8 µM 0.946576780767005 0.151137714781221 no 535 0.171927240145686 906 2790705 SGTC_2304 7443016 91.4 µM 0.945729804592013 0.151355440766677 no 536 0.172143208308534 790 939854 SGTC_692 k241-0027 77.8 µM 0.945271163722096 0.151473427245128 no 537 0.172260228133948 844 3600480 SGTC_3174 9107204 49.47 µM 0.943590413720901 0.151906326825346 no 538 0.172689496419965 838 3938802 SGTC_1701 st028638 40.4 µM 0.941376999616669 0.152477673878343 no 539 0.173255848039551 884 3490878 SGTC_1146 3579-1023 7 µM 0.940287998398911 0.152759299746301 no 540 0.173534927014666 937 X1146 SGTC_2124 5246320 200 µM 0.939601112185447 0.152937112243977 no 541 0.173711102791976 840 579342 SGTC_1188 1403-0014 4.57 µM 0.939229646601372 0.153033329751157 no 542 0.173806425404332 905 9614867 SGTC_232 clozapine 119 µM 0.938915567404087 0.153114714261357 no 543 0.173887047919938 868 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1789 tunicamycin 25 nM 0.938751468124037 0.15315724723538 no 544 0.173929180819191 866 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1844 rapamycin 4 nM 0.938587592945961 0.153199729937799 no 545 0.17397126265742 940 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1331 1472-0049 76.2 µM 0.93770694925732 0.153428160128717 no 546 0.174197515787305 812 24051409 SGTC_150 3970-0969 77.2 µM 0.936286807239891 0.15379700584148 no 547 0.174562769435752 904 6615640 SGTC_569 4130-2812 160 µM 0.93526289636809 0.154063304449501 no 548 0.174826415868937 768 743552 SGTC_1249 0481-0015 10.2 µM 0.933317779149225 0.154570029991476 no 549 0.175327959071385 826 4227577 SGTC_2262 9014885 67.46 µM 0.933150732470427 0.154613598888069 no 550 0.17537107410162 827 6457424 SGTC_369 0957-0393 4.5 µM 0.932623804676706 0.154751084680382 no 551 0.175507119094728 815 6997992 SGTC_2489 cantharidin 73.42 µM 0.932455766185242 0.154794946198877 no 552 0.175550518221045 848 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2184 6075246 200 µM 0.932349904809732 0.154822582421683 no 553 0.175577862420016 866 2267320 SGTC_559 1550-0661 158 µM 0.930376274195972 0.155338416219622 no 554 0.176088149219591 875 5830875 SGTC_424 splitomicin 100 mM 0.926183659204386 0.156437969873866 no 555 0.177175271569786 806 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_68 0986-0284 82.829 µM 0.919469716150391 0.158209416177113 no 556 0.178924969317071 727 423278 YIL048W NEO1 SGTC_2193 5925765 200 µM 0.918775431144892 0.158393348531538 no 557 0.179106522904548 869 877370 SGTC_842 0271-0008 11.1 µM 0.916852678323243 0.158903462677079 no 558 0.179609922018425 925 1221709 SGTC_2743 auranofin 4.32 µM 0.916082539563378 0.159108085276034 no 559 0.179811802476386 865 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_858 0438-0351 2.77 µM 0.914096793421465 0.15963648557605 no 560 0.180332993646599 933 2799119 SGTC_602 3130-1533 38.1 µM 0.910586571243144 0.160573349777159 no 561 0.181256624351004 953 720941 SGTC_539 4859-0462 2.54 µM 0.909864315387984 0.160766561579788 no 562 0.1814470355103 923 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1409 3909-8004 61.9 µM 0.90888880047244 0.161027763992234 no 563 0.181704413053854 919 2119279 SGTC_3293 9120939 62.045 µM 0.907690969182401 0.161348872123035 no 564 0.182020758291466 883 934087 SGTC_1676 st018489 23.4 µM 0.906721194032695 0.1616091499142 no 565 0.182277126381334 882 3696235 SGTC_211 3455-0679 143.504 µM 0.90500295061427 0.162070980670833 no 566 0.18273191201689 915 748649 SGTC_3338 9144300 39.5675 µM 0.904777347110805 0.16213168232469 no 567 0.182791677448357 903 4901274 SGTC_2502 avocadyne acetate 18.59 µM 0.904634857532319 0.162170028687626 no 568 0.18282943115894 994 3952079 SGTC_2752 diclazuril 33.15 µM 0.904397812669934 0.162233834564706 no 569 0.182892248802481 1051 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1289 0976-0073 69.1 µM 0.901745262148927 0.162948941900915 no 570 0.183596101592177 934 3391136 SGTC_1448 4255-0083 152 µM 0.901647247919447 0.162975404989793 no 571 0.18362214191112 959 5399660 SGTC_1916 st067606 49.2 µM 0.900703454161505 0.163230365022316 no 572 0.183873005825591 939 19590279 SGTC_542 3381-0244 89.3 µM 0.900392081897761 0.163314537135552 no 573 0.183955816544685 970 1112843 SGTC_2025 5147754 141 µM 0.8998966128604 0.163448533574395 no 574 0.184087636419498 914 315777 YLR208W SEC13 SGTC_2031 5180455 200 µM 0.899292078036145 0.163612122845876 no 575 0.184248552943726 883 29949 SGTC_1184 1269-1718 139 µM 0.897708778082007 0.164041073069049 no 576 0.184670414191657 934 5403821 SGTC_2139 5578692 56.4705 µM 0.893910128806723 0.165073181445344 no 577 0.185684988992467 890 650991 YMR113W FOL3 SGTC_631 k072-0230 41.5 µM 0.89206665277763 0.165575573214109 no 578 0.186178603823954 952 5773147 SGTC_1618 st003135 44.5 µM 0.891714624865875 0.16567162165748 no 579 0.186272956296459 910 1270615 SGTC_2820 7989630 71.43 µM 0.891159362529787 0.165823194459617 no 580 0.186421840997369 805 2984098 SGTC_1735 st034310 56.75 µM 0.889406975110346 0.166302140295151 no 581 0.186892198832697 891 871153 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.88816362341079 0.166642502587017 no 582 0.187226371489115 968 3256 An antibiotic and ribosome inhibitor. SGTC_2507 purpurin 79.67 µM 0.887894362285477 0.166716270865277 no 583 0.187298788798804 943 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_683 panaxydol 45 µM 0.886860004965249 0.166999845072407 no 584 0.187577138402398 950 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_600 1495-0418 41.6 µM 0.886724329469324 0.167037064248284 no 585 0.187613668162291 897 5377768 SGTC_3177 9107506 49.47 µM 0.88321670073923 0.168001150823717 no 586 0.1885595999515 905 8897194 SGTC_2376 9072922 81.32 µM 0.879014062044859 0.169160970014843 no 587 0.189696825689288 946 17087968 SGTC_1636 st007707 68.9 µM 0.878925958991028 0.169185339061923 no 588 0.189720711259567 955 403051 SGTC_1271 0832-2808 169 µM 0.878906418121832 0.169190744314596 no 589 0.189726009224448 976 3663794 SGTC_1751 st044839 27.194 µM 0.878407722187177 0.169328727466892 no 590 0.189861247591267 939 5291326 SGTC_2445 5742597 35.57 µM 0.877869502497317 0.169477727387299 no 591 0.190007270654279 890 1774255 SGTC_1796 st049173 110.4 µM 0.876765764891723 0.169783547511855 no 592 0.190306938854224 894 94134 SGTC_2515 chrysin 20.77 µM 0.876465642776577 0.169866765557323 no 593 0.19038847311929 957 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_697 0508-1955 564 µM 0.876395301959221 0.169886273485031 no 594 0.190407585733126 976 6243113 SGTC_780 0109-0199 192 µM 0.875755029004541 0.170063909233871 no 595 0.190581611294375 987 610414 SGTC_557 1315-0110 16.2 µM 0.874625453538057 0.170377586017202 no 596 0.190888866786345 992 6833801 SGTC_326 k292-0812 17.5 µM 0.874573154755215 0.170392118066792 no 597 0.190903099919872 943 3579357 SGTC_2289 7946404 165.07 µM 0.874376180154919 0.170446857721458 no 598 0.190956712475226 992 1246120 YPR165W RHO1 SGTC_2638 epoxomicin 18 µM 0.874084623787301 0.170527902517338 no 599 0.191036085250287 975 9915668 A protesome inhibitor. SGTC_2037 5169046 200 µM 0.872536537691474 0.17095864189356 no 600 0.191457872242133 944 5718022 SGTC_1126 isoteolin 1.0172 µM 0.872139543773023 0.171069213495819 no 601 0.19156612789634 921 133323 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.871352360302984 0.171288596771658 no 602 0.191780894592594 1016 1273210 SGTC_2541 muurolladie-3-one 83.07 µM 0.869858067381886 0.17170554173272 no 603 0.192188986795569 903 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3107 9121808 49.47 µM 0.868890946688492 0.171975737786895 no 604 0.192453390928814 933 662681 SGTC_1653 st012112 65 µM 0.867973380227834 0.172232340082616 no 605 0.192704452763192 917 720429 SGTC_2319 6033012 152.6 µM 0.867859204866946 0.172264286906661 no 606 0.19273570708427 868 847246 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.866851696052366 0.172546356666612 no 607 0.193011636408238 951 5357218 A potent inhibitor of glutathione S-transferases. SGTC_141 0443-0274 32.331 µM 0.866092592427798 0.172759075477812 no 608 0.193219693551308 1081 1627241 SGTC_1164 k060-0068 93.7 µM 0.865841152687356 0.172829571685134 no 609 0.193288638994548 1011 5963676 SGTC_672 1441-0018 53.7 µM 0.865487403690457 0.172928783394048 no 610 0.193385663323166 905 251141 SGTC_2806 7952793 58.44 µM 0.8649816143618 0.173070699041076 no 611 0.193524440044792 936 2972490 SGTC_2065 5221596 34.26 µM 0.863188102373726 0.173574524900793 no 612 0.194017027043796 916 788581 SGTC_3270 9137563 49.47 µM 0.862743697084529 0.173699509507981 no 613 0.194139200688769 911 17015724 SGTC_56 0957-0365 83.25 µM 0.861121982895147 0.174156086163275 no 614 0.194585431502925 947 6752360 SGTC_491 tetrandrine 80.3 µM 0.859784449215086 0.174533228224956 no 615 0.194953936487699 929 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2308 7584454 197.62 µM 0.855244867756853 0.175817110158299 no 616 0.196207800963395 999 893577 SGTC_3181 9108277 49.47 µM 0.854829739372569 0.175934814336932 no 617 0.196322705871669 962 17097298 SGTC_1248 0469-0687 58.6 µM 0.853998910497679 0.176170534739728 no 618 0.196552796527402 958 4017482 SGTC_2166 5933061 31.504 µM 0.850046695340112 0.177294581335013 no 619 0.197649562781497 1037 2877375 SGTC_2052 5265182 7.135 µM 0.849217393629373 0.177531016029969 no 620 0.197880168219065 978 1239884 SGTC_1405 3909-7894 12 µM 0.847897304231763 0.177907785059 no 621 0.198247582998109 991 7104060 SGTC_989 1501-0895 10.3 µM 0.847706918815236 0.177962164873673 no 622 0.19830060610416 991 2830112 SGTC_630 4356-0227 183 µM 0.84680376592558 0.178220275345696 no 623 0.198552254410184 950 779312 SGTC_1185 1319-0113 81.3 µM 0.845775212492487 0.178514511015917 no 624 0.198839077944804 943 4672763 SGTC_1457 k015-0032 57.3 µM 0.845638781550089 0.178553562441045 no 625 0.19887714197985 956 4302660 SGTC_3028 9087778 49.47 µM 0.844635145503775 0.178841004397951 no 626 0.199157289953838 1003 17217395 SGTC_2794 7785382 27.27 µM 0.844070269152284 0.179002913345292 no 627 0.199315070098744 1039 2205081 SGTC_3305 9127027 53.8275 µM 0.841267902574981 0.179807511070783 no 628 0.200098933931968 971 41905295 SGTC_3226 9131256 49.47 µM 0.841097995213797 0.179856366731724 no 629 0.200146519067989 900 17178073 SGTC_2095 5432005 200 µM 0.839913602832705 0.180197161991016 no 630 0.200478415050466 936 783734 SGTC_1048 3161-0300 24.5 µM 0.83855875335229 0.180587500963048 no 631 0.200858482374466 1030 2165101 SGTC_749 1000-0129 128 µM 0.838133753155305 0.180710054843677 no 632 0.200977794012474 1041 708470 SGTC_173 1273-0061 2.693 µM 0.83618656573292 0.181272216108126 no 633 0.201524977459828 954 2847414 YPL266W DIM1 SGTC_1021 4476-0760 85.3 µM 0.836094333472301 0.181298871090732 no 634 0.201550917974215 979 746768 SGTC_1205 4161-2785 76 µM 0.83484326189714 0.181660671274542 no 635 0.201902982022477 867 3498106 SGTC_2711 st079103 59.1 µM 0.831885231396247 0.182517906080496 no 636 0.202736864373226 980 54693780 SGTC_2202 7226349 200 µM 0.828502601945833 0.183501280402125 no 637 0.203692960997094 980 844334 SGTC_3117 9124945 49.47 µM 0.828447594467197 0.18351729903032 no 638 0.203708530983672 895 17592065 SGTC_3272 9137413 49.47 µM 0.828273528099807 0.183567994324188 no 639 0.203757805523046 1020 17614870 SGTC_321 4534-3890 65.3 µM 0.828038256629814 0.183636528932995 no 640 0.203824417234778 1031 699746 SGTC_3225 9130819 49.47 µM 0.827048348527445 0.183925063924267 no 641 0.204104829138817 1009 4547121 SGTC_3269 9137823 49.47 µM 0.826497713728224 0.18408568318089 no 642 0.204260907224829 921 17682936 SGTC_3069 9117009 49.47 µM 0.822581517951582 0.185230548439522 no 643 0.205373006191452 888 41904981 SGTC_402 epigallocatechin gallate 10 µM 0.822018326288427 0.185395555460486 no 644 0.205533233403576 1009 65064 An antioxidant. SGTC_1893 st059353 36.1 µM 0.820266103251379 0.185909514840906 no 645 0.206032212759665 969 3112488 SGTC_1032 k061-1018 98.7 µM 0.818782308362171 0.186345429457749 no 646 0.206455313231993 1093 4005393 SGTC_1425 4048-4433 7.33 µM 0.817785675642858 0.186638579020007 no 647 0.206739789383362 1079 23734946 SGTC_920 mycophenolic acid 780.421 nM 0.817375974257153 0.186759171360518 no 648 0.206856800720487 973 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_824 1304-0008 100 µM 0.814163450796609 0.187706423004319 no 649 0.20777566023517 1009 768245 SGTC_1848 st056003 16.4 µM 0.812148977613247 0.188301926205292 no 650 0.208353076183564 1114 146492 SGTC_2141 5621638 7.665 µM 0.810252834640848 0.188863513104993 no 651 0.20889743849992 1030 2856238 SGTC_3082 9117008 49.47 µM 0.809023719900733 0.189228094774108 no 652 0.20925075132017 1007 41448529 SGTC_3004 9076122 71.4286 µM 0.808130092372024 0.189493435632173 no 653 0.209507848000578 1025 44782551 SGTC_530 4358-1714 28 µM 0.807803879307758 0.189590353645733 no 654 0.209601745793314 1045 1564641 SGTC_157 1348-1695 65.819 µM 0.807249196550775 0.18975522008142 no 655 0.209761463551929 1013 5380510 SGTC_822 1487-0950 154 µM 0.807082916858761 0.189804659990803 no 656 0.209809356784262 1039 1958375 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.804778741817139 0.190490575074748 no 657 0.210473685532871 959 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2747 doxorubicin 7.63 µM 0.804710055868863 0.190511045087599 no 658 0.21049350766968 890 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_420 mitomycin C 81.9 mM 0.803328004801084 0.190923215448954 no 659 0.210892587747808 1009 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_886 0866-0150 153 µM 0.801989457625543 0.191322932635306 no 660 0.211279528284112 1089 271463 SGTC_2021 4019055 173 µM 0.801811258241229 0.191376185225772 no 661 0.211331072625461 1079 44827708 YER133W GLC7 SGTC_661 1304-0007 33.6 µM 0.796109068458236 0.193085003810997 no 662 0.21298432185084 1003 3117130 SGTC_223 busulfan 5 mM 0.794839868536178 0.193466618341488 no 663 0.213353328117026 982 2478 A DNA alkylator. SGTC_993 3909-8757 62.7 µM 0.793790988925563 0.193782335410434 no 664 0.213658559702667 961 4288324 YLR208W SEC13 SGTC_1697 st025554 27.742 µM 0.792802916027385 0.194080036526692 no 665 0.213946328653159 1050 1269519 SGTC_202 3594-0513 34.79 µM 0.792180014924236 0.194267856431641 no 666 0.214127859911765 1037 708429 SGTC_1901 st060216 58.6 µM 0.791578446739645 0.194449348965637 no 667 0.214303259194329 1077 688792 SGTC_1034 k072-0165 12.7 µM 0.791395147927226 0.194504670547674 no 668 0.214356720250512 1071 5835461 SGTC_1766 st045414 44.774 µM 0.790811619752815 0.194680849499747 no 669 0.214526964116558 1126 253960 SGTC_1946 st076057 65.1 µM 0.790785206908208 0.1946888263676 no 670 0.214534671901361 949 953009 SGTC_1162 k048-0130 20.1 µM 0.787761248729438 0.195603397503618 no 671 0.215418185882621 1019 6797406 SGTC_789 1309-1135 70.6 µM 0.785988307321672 0.196140819949194 no 672 0.21593716866985 1098 3092424 SGTC_2606 farnesol 9.78 µM 0.785664271260759 0.196239140001909 no 673 0.21603210009547 1060 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_347 4534-1311 26.2 µM 0.78494928186216 0.196456190046422 no 674 0.216241652910385 1079 2862016 SGTC_2035 5154463 94.595 µM 0.783450117878384 0.196911764837748 no 675 0.216681417576314 1058 2769623 SGTC_695 3505-6186 243 µM 0.78271795950559 0.197134489705934 no 676 0.216896376723969 1070 1819379 SGTC_3234 9132280 49.47 µM 0.781763292938966 0.197425131125844 no 677 0.217176848580868 1081 17612295 SGTC_1509 1326-1131 80 µM 0.781207612867576 0.197594423200997 no 678 0.217340198464017 1035 768313 SGTC_1449 4112-4002 201 µM 0.778851892863343 0.198313084868558 no 679 0.218033482557566 1028 2059539 SGTC_996 3970-0799 1.8 µM 0.777829847283425 0.198625371294602 no 680 0.218334664807534 1214 6615648 YGL040C HEM2 SGTC_2479 5617353 43.85 µM 0.775536918801586 0.199327054697967 no 681 0.219011229406975 1058 2731746 SGTC_922 1866-0035 480 µM 0.775534019590562 0.19932794286012 no 682 0.219012085627318 1115 3156169 SGTC_638 3970-0837 4.09 µM 0.773031742092268 0.200095394273353 no 683 0.219751797661892 1076 4118451 YLR208W SEC13 SGTC_51 1013-0126 23.419 µM 0.770729564585756 0.200803041231085 no 684 0.220433622099632 1051 1627850 SGTC_3091 9116372 49.47 µM 0.770502163370022 0.200873021589005 no 685 0.220501036118311 1051 17169793 SGTC_1806 st050005 60.3 µM 0.769754131890551 0.201103323718661 no 686 0.220722876436886 1069 5194765 SGTC_464 bw-b 70c 158 µM 0.768541190325822 0.201477097646582 no 687 0.221082864586466 1110 5353454 SGTC_805 3852-0218 479 µM 0.767806661630368 0.201703648530967 no 688 0.221301028118861 1055 6615355 SGTC_275 trichlorophene 5.69 µM 0.766472049191047 0.202115673663931 no 689 0.221697738407205 1130 62616 SGTC_1512 0259-0544 12.2 µM 0.766214818022122 0.202195144609489 no 690 0.221774246422246 1110 18476 SGTC_2516 gossypol 71.55 µM 0.766044990518167 0.202247622648705 no 691 0.221824766315801 1105 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1001 4048-4355 44.4 µM 0.765113665456269 0.202535554267654 no 692 0.22210193158499 1067 21824233 SGTC_2921 7974240 10.71 µM 0.764507493380046 0.202723092068774 no 693 0.222282436453393 1076 2979074 YDR527W RBA50 SGTC_2802 7925815 54.55 µM 0.76329476230967 0.203098598693581 no 694 0.222643812520368 1075 1262923 SGTC_135 0933-0004 26.348 µM 0.762259463659966 0.203419493988461 no 695 0.222952581142459 1029 21230617 YGL099W LSG1 SGTC_1157 4092-0394 27.6 µM 0.761262257416759 0.203728868192066 no 696 0.223250219521789 1150 3659885 SGTC_3047 9092122 49.47 µM 0.759005274186085 0.204430111893141 no 697 0.223924700890639 1082 17173831 SGTC_3176 9106582 49.47 µM 0.7577886881026 0.204808699850215 no 698 0.224288747669616 1004 17018027 SGTC_1354 1498-1681 81 µM 0.756471710482291 0.205218998159264 no 699 0.224683213718433 1125 5754243 SGTC_403 arphamenine a 50 µM 0.755889802547339 0.205400444350686 no 700 0.224857634216672 1073 5487158 An arginine aminopeptidase inhibitor. SGTC_2967 9089538 49.85 µM 0.755208827113114 0.205612901975646 no 701 0.225061846551053 1134 728216 SGTC_656 4090-1979 187 µM 0.755197535699632 0.205616425884478 no 702 0.225065233529168 1146 22330961 SGTC_1183 1254-0324 198 µM 0.755045519089468 0.205663871856249 no 703 0.225110835320443 1107 5799357 SGTC_1315 1237-0019 3.69 µM 0.754879088281252 0.205715824100722 no 704 0.225160767070948 1109 825140 SGTC_2918 7977171 22.06 µM 0.753844391056591 0.20603898491941 no 705 0.225471332548454 1083 2236483 SGTC_1804 st050076 49.1 µM 0.753755225274441 0.206066847619494 no 706 0.225498107096836 1084 3895976 SGTC_2013 4024628 200 µM 0.753473435689128 0.206154916473758 no 707 0.225582734220581 1092 5230760 SGTC_1196 1588-0294 184 µM 0.75080052910623 0.206991400066904 no 708 0.226386355477324 1060 6144269 SGTC_194 1486-1323 56.904 µM 0.750267576635319 0.20715842686774 no 709 0.226546783121654 1122 5178754 SGTC_1939 st074455 53.6 µM 0.750207565435345 0.207177239313595 no 710 0.226564851520121 1103 1644229 SGTC_1705 st027868 56.3335 µM 0.749755932871176 0.207318850519606 no 711 0.226700856851891 1138 292948 SGTC_921 1561-0023 372 µM 0.749200580627408 0.207493061883212 no 712 0.226868159630831 1159 24050882 SGTC_2191 5911152 200 µM 0.747944989185328 0.207887253765188 no 713 0.227246669762287 1113 2875902 SGTC_1794 st048918 76.9 µM 0.747322829253564 0.208082744093734 no 714 0.227434357650339 1062 672303 SGTC_2168 5727979 200 µM 0.746837038932224 0.208235460817076 no 715 0.227580967407227 1060 695210 SGTC_1128 3448-9350 235 µM 0.74654127392569 0.208328472123216 no 716 0.227670254269601 1050 619386 SGTC_859 0439-0102 54.6 µM 0.746422783832415 0.208365741412649 no 717 0.227706030120606 1153 610143 SGTC_3063 1327-0034 4 µM 0.744627475233659 0.208930909974156 no 718 0.228248476779096 1059 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1136 pergolide 1.05886 µM 0.744030250617493 0.209119118063012 no 719 0.228429087141356 1073 47811 A dopamine receptor agonist. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.743222424549175 0.209373853418192 no 720 0.228673514499981 1133 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1234 0326-0494 15.5 µM 0.74244932734398 0.209617808478553 no 721 0.228907571266429 1135 1547813 SGTC_250 brefeldin a 552.239 µM 0.742372504227669 0.209642059562091 no 722 0.228930836964062 1030 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1018 4259-0013 28.1 µM 0.741393165563352 0.209951356170901 no 723 0.229227543599152 1097 6801262 SGTC_1617 st002906 78 µM 0.740402202808571 0.210264596716915 no 724 0.229527991303271 1121 5150859 SGTC_1782 st039423 80.636 µM 0.739166228189433 0.210655669189343 no 725 0.229903032620192 1093 2068169 SGTC_344 k064-0035 6.43 µM 0.739000651166698 0.210708091507022 no 726 0.229953300976586 1109 5088750 SGTC_2746 daunorubicin 9.88 µM 0.738080001676438 0.21099971219537 no 727 0.230232917731319 1033 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2776 terbinafine 19.92 µM 0.737773619259742 0.211096812924051 no 728 0.230326013387503 1158 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3311 9131146 2.8755 µM 0.737307711142858 0.21124452176939 no 729 0.230467621969519 1087 4900406 YPR165W RHO1 SGTC_2252 omeprazole 400 µM 0.736602989060581 0.211468057859488 no 730 0.230681908356842 1055 4594 A proton pump inhibitor. SGTC_502 l-744,832 89.3 µM 0.736240140453617 0.211583206533817 no 731 0.230792283923223 1119 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2975 9084847 53.72 µM 0.735497037581737 0.211819142035481 no 732 0.231018421747647 1107 27211724 SGTC_1520 flindersine 88 µM 0.733979646293463 0.212301392271039 no 733 0.231480571551256 1182 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1764 st044502 93.5 µM 0.73290301739944 0.212643950277317 no 734 0.2318087913148 1145 8407 SGTC_3301 9125354 19.7965 µM 0.731810533678995 0.212991882635193 no 735 0.232142109400399 1096 41905162 SGTC_1724 st037281 8.293 µM 0.729401723352819 0.213760209035518 no 736 0.232877981967035 1157 574124 YDL195W SEC31 SGTC_814 3342-0569 96 µM 0.727082946983231 0.214501340332883 no 737 0.233587572302233 1176 4346283 SGTC_1868 st057644 42.7 µM 0.727071641994403 0.2145049573086 no 738 0.233591034781516 1173 688665 SGTC_979 1426-2828 121 µM 0.724390716385683 0.21536370711439 no 739 0.234412948844292 1194 747872 SGTC_43 0570-0105 72.5 µM 0.724008625960635 0.215486259903282 no 740 0.234530219689688 1183 1114046 YDL195W SEC31 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.72225832840473 0.216048172218585 no 741 0.235067834037449 1172 551469 SGTC_1151 3909-8316 15.3 µM 0.72221591280404 0.216061799770208 no 742 0.23508087068551 1164 800431 SGTC_1491 4138-0063 26.5 µM 0.721890983078887 0.216166211756326 no 743 0.235180752716799 1131 23883227 SGTC_3141 9094609 49.47 µM 0.721598630377032 0.216260180501989 no 744 0.23527064073366 1115 25236309 YDL196W YDL196W SGTC_34 0469-0683 81.75 µM 0.721163492144907 0.216400087521297 no 745 0.235404465322091 1153 3690923 SGTC_182 3448-4371 550.524 µM 0.720742744421848 0.21653541745971 no 746 0.235533904122446 1179 3491403 SGTC_1687 st020778 55.3625 µM 0.720079477007435 0.216748851205566 no 747 0.235738031382392 1182 4259299 SGTC_2192 5915882 198.485 µM 0.718160492307121 0.217367048693915 no 748 0.236329167400362 1125 2876149 SGTC_556 4058-0063 51.5 µM 0.717778504433018 0.217490226791914 no 749 0.23644693465148 1208 6615692 SGTC_2760 etidronate 98.04 µM 0.717603224553873 0.217546762075516 no 750 0.2365009844266 1172 3305 A chelator and antioxidant. SGTC_1237 0330-0133 46.1 µM 0.717107347178519 0.217706749744724 no 751 0.236653931330494 1109 X1237 YHR072W ERG7 SGTC_113 0099-0221 2.5 µM 0.714808104019876 0.218449453830781 no 752 0.237363813440012 1156 89219 SGTC_3111 9122088 49.47 µM 0.7146508201206 0.21850031311906 no 753 0.237412416904413 1081 16876704 SGTC_2602 kawain 100 µM 0.7145653578419 0.218527951042147 no 754 0.237438828527984 1170 5369129 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.714471795978986 0.218558210624019 no 755 0.237467745130775 1038 6708630 An antioxidant. SGTC_3144 9087057 49.47 µM 0.714374095912373 0.218589811149785 no 756 0.237497942766517 1111 17249618 SGTC_2708 st078559 56 µM 0.713783023811996 0.218781046114529 no 757 0.237680679293481 1089 17250902 SGTC_1422 4031-0024 15.5 µM 0.71288966829939 0.219070264238018 no 758 0.237957016447085 1138 782427 SGTC_2358 9037157 4 µM 0.71198989215863 0.219361783107835 no 759 0.238235517608567 1168 2388925 SGTC_1831 st055328 12 µM 0.711797819355133 0.219424041719693 no 760 0.238294991625094 1170 1103068 SGTC_1275 0867-0008 21.1 µM 0.709090452617247 0.220302688911485 no 761 0.239134173650732 1159 3422836 SGTC_414 piperonyl butoxide 100 µM 0.708445293722551 0.220512365623695 no 762 0.239334386719631 1172 5794 A potent inhibitor of cytochrome P450. SGTC_153 4077-0274 519.67 µM 0.706252609226284 0.221225842513714 no 763 0.240015529513394 1246 3121976 SGTC_3128 9127691 49.47 µM 0.705302599959069 0.221535375260098 no 764 0.240310971405196 1111 41316314 SGTC_2608 thymoquinone 42.66 µM 0.702932611305117 0.222308644939261 no 765 0.241048873382919 1121 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_777 1315-0167 517 µM 0.70257814909334 0.222424429572637 no 766 0.241159341908764 1157 4221767 SGTC_1252 0493-0875 34.8 µM 0.701959492860709 0.222626595227122 no 767 0.241352212696178 1200 3960963 SGTC_485 niflumic acid 177 µM 0.701882444167403 0.222651780678183 no 768 0.241376239079851 1165 4488 A COX2 inhibitor. SGTC_563 tetrahydrosecaminediol 614 µM 0.701580431120996 0.222750517476367 no 769 0.241470429471419 1225 334274 A psychoactive constituent of the cannabis plant. SGTC_2391 6285546 200 µM 0.701444372371313 0.222795007167721 no 770 0.241512869348478 1166 846083 SGTC_152 4469-0003 551.229 µM 0.701139133278354 0.222894835361245 no 771 0.24160809523141 1176 697280 SGTC_473 2-arachidonoylglycerol 10 µM 0.698638715469828 0.22371355368159 no 772 0.242388921127752 1145 5282280 An endocannabinoid. SGTC_2112 5488546 200 µM 0.696941805475606 0.224270149842833 no 773 0.242919606861269 1180 600757 SGTC_1060 3448-7350 82 µM 0.696795614046967 0.224318138222998 no 774 0.242965355653176 1152 570178 SGTC_1919 st067113 52.3 µM 0.696036265556892 0.224567493540174 no 775 0.243203059293623 1180 1268243 SGTC_73 0327-0325 16.231 µM 0.691717016135633 0.225988838890665 no 776 0.244557529395946 1238 53298 SGTC_2245 6637752 200 µM 0.691199612307219 0.226159442598586 no 777 0.244720053744837 1167 681890 SGTC_869 0564-0080 44.1 µM 0.688225230722984 0.227141596829092 no 778 0.245655478852775 1189 6843321 SGTC_712 r015-0009 80.6 µM 0.685894656120141 0.227912840165133 no 779 0.246389770134296 1165 6813872 YLR060W FRS1 SGTC_2200 6600604 21.907 µM 0.685218872456474 0.228136748506093 no 780 0.246602908256978 1182 2904777 SGTC_874 0599-0792 117 µM 0.683479128073552 0.228713749149724 no 781 0.247152067301267 1243 765305 SGTC_2656 pseudo-anisatin 100 µM 0.683297974700422 0.228773877232869 no 782 0.247209286846952 1234 6708809 A neurotoxin. SGTC_2991 9074669 71.4286 µM 0.680331361268895 0.229759811596935 no 783 0.248147335646058 1224 17333109 SGTC_358 0075-0058 9.45 µM 0.680123738312527 0.229828902690466 no 784 0.248213057429585 1227 1069125 SGTC_2145 5634607 200 µM 0.679437535993593 0.23005733430115 no 785 0.248430336617905 1194 308662 SGTC_159 3970-0959 50 µM 0.678196668577921 0.2304707321707 no 786 0.248823502276357 1309 6615653 SGTC_1931 st074438 57.1 µM 0.677293437068602 0.230771906793759 no 787 0.249109897044896 1197 2787313 SGTC_2087 5276107 200 µM 0.676446037380229 0.231054664536802 no 788 0.249378748119543 1211 144405 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.675380843896708 0.231410369192746 no 789 0.249716916415234 1238 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1284 0929-0043 16 µM 0.674490759476595 0.231707832962646 no 790 0.249999679274407 1207 1239883 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.674371393586726 0.231747740911344 no 791 0.250037612458875 1263 368090 SGTC_1975 st070967 30.8 µM 0.673919087346423 0.231898996529309 no 792 0.250181378179237 1238 261391 SGTC_3055 9094636 49.47 µM 0.673900050037337 0.231905363996666 no 793 0.250187430156889 1266 25236176 SGTC_3064 1327-0027 10 µM 0.673628908961572 0.231996063955421 no 794 0.250273634575678 1125 16000455 YPR107C YTH1 SGTC_3093 9117344 49.47 µM 0.67347953376125 0.232046040197635 no 795 0.250321132456011 1223 24824913 SGTC_266 formosanin C 406 nM 0.67122306924039 0.232801710920929 no 796 0.251039217286435 1216 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1640 st009078 66.4 µM 0.671176677845413 0.23281726133535 no 797 0.251053992053839 1243 690618 SGTC_1362 1611-0397 101 µM 0.670544808070496 0.233029121795073 no 798 0.251255276227721 1224 27816 SGTC_1211 1056-0033 32.3 µM 0.66947158986111 0.233389207781182 no 799 0.251597348840567 1242 6741922 SGTC_1856 st057054 55.7 µM 0.669388706317952 0.233417029688355 no 800 0.251623776988007 1309 1266018 SGTC_1820 st053765 18.6 µM 0.667964103902757 0.233895520143702 no 801 0.252078253120995 1216 3690829 SGTC_2411 st077133 39.94 µM 0.667871556369062 0.233926623473249 no 802 0.252107792573503 1341 1403142 YNL221C POP1 SGTC_3189 9110682 49.47 µM 0.667538387303398 0.234038613740386 no 803 0.252214149063573 1274 17122418 SGTC_2272 7805186 180 µM 0.667027644911541 0.234210350514702 no 804 0.252377237643207 1220 2956062 YPR165W RHO1 SGTC_3076 9116187 49.47 µM 0.666711823196106 0.234316580246641 no 805 0.25247811260079 1193 27241210 SGTC_2295 7971645 200 µM 0.666585600525299 0.234359043937832 no 806 0.252518434663857 1244 2978226 YKL099C UTP11 SGTC_2448 5185112 27.17 µM 0.664839484177827 0.234946907216397 no 807 0.253076582670615 1230 5718189 SGTC_2811 7967822 32.47 µM 0.664280546040546 0.235135256385807 no 808 0.253255384885999 1259 2232244 SGTC_1395 3486-0190 4.35 µM 0.664173584994033 0.235171309277925 no 809 0.253289608894001 1279 6748079 SGTC_3032 9089427 49.47 µM 0.664012709196747 0.235225540727605 no 810 0.253341088423028 1223 17173707 SGTC_1326 1431-2094 10.8 µM 0.661861236225615 0.235951468494356 no 811 0.254030078337644 1226 616278 SGTC_1554 st069299 38.7 µM 0.659631715493733 0.236705031180387 no 812 0.254745098198937 1246 24207999 SGTC_331 k048-0133 24.5 µM 0.657482883847179 0.237432572510802 no 813 0.25543523652674 1230 6813582 SGTC_1384 3089-0840 101 µM 0.656637706263493 0.237719064801776 no 814 0.255706948911452 1242 1069836 SGTC_3049 9092223 49.47 µM 0.655781167200808 0.238009601699252 no 815 0.25598246773768 1224 8623917 SGTC_2786 7743617 45.45 µM 0.655244972437124 0.238191577258093 no 816 0.256155021737128 1183 583674 SGTC_3136 9095672 49.47 µM 0.655228268707883 0.238197247449285 no 817 0.256160398174491 1110 17217380 SGTC_1079 idarubicin 2.36 µM 0.655170125531339 0.238216985111228 no 818 0.25617911320558 1236 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3327 9140648 26.9345 µM 0.651507953277089 0.239461973845771 no 819 0.25735932236882 1250 8029710 SGTC_564 3555-0129 330 µM 0.650808234046946 0.239700253393594 no 820 0.257585142133201 1188 563260 SGTC_3233 9132340 49.47 µM 0.648875772780821 0.240358997520883 no 821 0.258209337744607 1232 17682950 SGTC_1387 3342-1166 1.8 µM 0.64875310757216 0.240400845325751 no 822 0.25824898573016 1263 3418228 SGTC_2895 9054447 58.44 µM 0.648043743283174 0.240642926060068 no 823 0.258478329119443 1291 2697450 SGTC_2545 solidagenone 89.61 µM 0.647331537111124 0.240886110061399 no 824 0.258708697400859 1128 6708572 An anti ulcer agent SGTC_823 0417-1665 178 µM 0.646110351151139 0.241303397022826 no 825 0.259103946107864 1290 3429856 SGTC_568 1193-0097 7.48 µM 0.643619422172402 0.242155779571754 no 826 0.259911126323168 1190 3646150 SGTC_1774 st048371 48.465 µM 0.64324797110361 0.24228302785184 no 827 0.260031605284795 1243 4242727 SGTC_2129 girgensonine 121.053 µM 0.642933263092055 0.242390865970537 no 828 0.260133702347401 1328 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_382 3229-0966 23.2 µM 0.642791474875041 0.24243945973952 no 829 0.260179707802033 1307 5722370 SGTC_877 0771-0151 33.1 µM 0.642323515339891 0.242599876644129 no 830 0.260331574511237 1310 6166523 SGTC_305 1682-2595 20.8 µM 0.641892878888874 0.242747549934183 no 831 0.260471369114654 1291 226033 SGTC_178 4092-0806 87.505 µM 0.641497441811603 0.242883195542497 no 832 0.26059977122174 1275 2169044 SGTC_943 3253-1379 105 µM 0.6410469869497 0.243037763694217 no 833 0.260746077805943 1295 668464 SGTC_212 3807-4682 38.772 µM 0.641012126131586 0.243049727980981 no 834 0.260757402272068 1356 3125501 YBL034C STU1 SGTC_1962 st076595 64.5 µM 0.639995504931058 0.243398774007393 no 835 0.261087760872251 1303 279619 SGTC_2568 diosmetin 100 µM 0.639510002149704 0.243565561711553 no 836 0.261245604474676 1284 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2933 9026794 32.47 µM 0.639364234569352 0.243615650175215 no 837 0.261293005079563 1304 17586027 SGTC_451 chloral hydrate 100 µM 0.639303879018926 0.243636391098106 no 838 0.261312632750686 1332 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_852 0418-0143 439 µM 0.63855143375958 0.243895045670706 no 839 0.261557392086925 1309 5369229 SGTC_1940 st075990 51.1 µM 0.638065821425513 0.244062054528766 no 840 0.261715417071068 1373 1084979 SGTC_57 miconazole 162.5 nM 0.636219617557622 0.244697552432651 no 841 0.262316644215054 1218 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_930 2810-3379 265 µM 0.635963262334046 0.244785865088934 no 842 0.262400183698851 1401 1015764 SGTC_1623 st003709 20.3 µM 0.635876811103926 0.244815650826377 no 843 0.262428358972189 1280 16192618 SGTC_444 curcumin 90.4 µM 0.635744091538536 0.244861381561515 no 844 0.262471616547624 1261 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2260 7964312 200 µM 0.635437581137522 0.244967012388436 no 845 0.262571532094551 1325 231951 SGTC_1503 4585-0012 61.3 µM 0.634415838789409 0.245319306291236 no 846 0.262904737825787 1323 2922052 SGTC_1787 fluconazole 80 µM 0.632243759383216 0.246069137146754 no 847 0.263613803584853 1202 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1857 st056007 79.3 µM 0.631919357821836 0.246181230328661 no 848 0.26371978672764 1297 619834 SGTC_308 4092-1169 104 µM 0.631644623736979 0.246276182903222 no 849 0.263809560322543 1262 2268590 YDL196W YDL196W SGTC_941 3237-0776 460 µM 0.630575736931307 0.246645794316822 no 850 0.264158983742896 1327 760008 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.630039515778118 0.246831326596562 no 851 0.264334365362452 1286 16623 A steroid. SGTC_905 2-aminofluorene 215 µM 0.629657599640816 0.246963514949494 no 852 0.2644593146442 1314 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3283 9109332 35.8195 µM 0.62834845096203 0.247416923247683 no 853 0.26488784919302 1236 17027281 SGTC_764 1951-2361 146 µM 0.626845639464428 0.24793795236531 no 854 0.265380211749553 1272 5438930 SGTC_131 0141-0277 33.849 µM 0.626482581312042 0.24806391344498 no 855 0.26549922924831 1303 1547771 SGTC_669 0108-0021 26.2 µM 0.624135150378125 0.248879165332204 no 856 0.266269415620717 1451 17201 SGTC_2652 actinonin 100 µM 0.623843427046919 0.248980579029594 no 857 0.26636520827512 1283 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_127 0180-0333 59.125 µM 0.623391931314947 0.249137578799465 no 858 0.266513499470422 1277 771601 SGTC_1855 st056195 39.6 µM 0.620419803495214 0.250172397346927 no 859 0.267490718878436 1304 4028379 SGTC_1627 st003713 25.6 µM 0.620315857729587 0.250208629805037 no 860 0.267524928352416 1330 16195070 YER133W GLC7 SGTC_130 0136-0219 337.655 µM 0.619475485733139 0.25050166110843 no 861 0.267801583222644 1285 234244 SGTC_1635 st007035 42.4 µM 0.618158273857022 0.25096132848555 no 862 0.268235506103083 1340 3716403 SGTC_640 3381-0960 37.1 µM 0.616587127240541 0.251510194665276 no 863 0.268753543709147 1370 1745025 SGTC_977 1348-1378 135 µM 0.616106979022769 0.251678056650231 no 864 0.268911958120998 1294 X977 SGTC_1133 3473-0247 50 µM 0.613492969284162 0.252592963200264 no 865 0.269775215086637 1282 711311 SGTC_536 3852-0578 10.6 µM 0.613116680420172 0.252724808861474 no 866 0.269899595803948 1384 2869208 SGTC_2788 5282734 71.43 µM 0.612894362764507 0.252802722475699 no 867 0.269973095466955 1399 743706 SGTC_671 0560-0003 407 µM 0.611543921636153 0.253276270680431 no 868 0.270419775201392 1274 3238678 SGTC_1987 st072290 61.9 µM 0.609425949402024 0.25401990103365 no 869 0.27112107105136 1359 54697379 SGTC_1881 5652484 16 µM 0.609223582843045 0.25409101282279 no 870 0.271188125424638 1313 2255129 SGTC_3255 9139072 49.47 µM 0.608227660310652 0.254441132985044 no 871 0.271518245837524 1329 17646060 SGTC_2079 5212404 121 µM 0.607759759239723 0.254605712543075 no 872 0.271673411009028 1359 758462 SGTC_254 nsc-64875 3.808 µM 0.607509497646242 0.254693762456817 no 873 0.271756420777144 1429 56993 SGTC_2201 6605497 169.863 µM 0.607421194212013 0.254724834192489 no 874 0.271785713332284 1335 670741 SGTC_168 3970-0862 530.542 µM 0.605288425367731 0.255475903849844 no 875 0.272493685378873 1342 3135186 SGTC_2765 myclobutanil 7.74 µM 0.603286073931796 0.256182097766451 no 876 0.27315919780371 1345 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2839 9003951 25.97 µM 0.602612206873103 0.256419987463857 no 877 0.273383348924543 1343 2990634 SGTC_2650 prasterone 100 µM 0.601901459461437 0.256671021397744 no 878 0.273619866357064 1309 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1631 benzylvanillin 81.9 µM 0.601618477846371 0.256771005292754 no 879 0.273714063124576 1357 75506 SGTC_3288 9119690 36.221 µM 0.600921579141653 0.257017322005954 no 880 0.273946109837475 1301 17595618 YKL019W RAM2 SGTC_763 3453-1109 128 µM 0.600285120683547 0.257242383635474 no 881 0.274158116651075 1338 1560353 SGTC_149 3970-0822 46.1 µM 0.600047778822759 0.257326337634121 no 882 0.274237196899044 1407 3114250 YBL034C STU1 SGTC_10 0279-0212 42.575 µM 0.598409665167145 0.257906169174613 no 883 0.274783309134099 1342 39851 YBR002C RER2 SGTC_1829 berberine 14.4 µM 0.598342321146482 0.257930020961352 no 884 0.27480577166597 1409 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2549 cedrol 20.94 µM 0.597646768203778 0.258176437612109 no 885 0.275037825606371 1373 6708665 A sedative which affects the nervous system. SGTC_1403 3909-7815 62.9 µM 0.594336035035641 0.259351016695595 no 886 0.276143690748533 1347 6615483 SGTC_1496 4469-0713 57.4 µM 0.594143639108502 0.259419359543958 no 887 0.276208022695039 1361 746691 SGTC_1318 1280-3875 124 µM 0.593170803577325 0.25976507240575 no 888 0.276533424918648 1349 373245 SGTC_171 k064-0041 9.68 µM 0.59312433996605 0.259781589949147 no 889 0.276548971160048 1303 53325 SGTC_790 1575-0012 79.1 µM 0.592922374953927 0.259853393632892 no 890 0.276616551532297 1381 378741 YLR208W SEC13 SGTC_285 1486-1325 46 µM 0.590920882695951 0.260565528000973 no 891 0.27728671660643 1389 22310230 SGTC_370 0180-0345 38.7 µM 0.590614346526121 0.260674682751422 no 892 0.277389425019724 1320 3989527 SGTC_1465 k213-0056 144 µM 0.589321362161638 0.261135361609653 no 893 0.277822858645919 1323 24048857 YMR208W ERG12 SGTC_1215 3852-0577 11.2 µM 0.588877245610578 0.261293692888371 no 894 0.277971811448845 1454 2884876 SGTC_3343 9148379 18.9835 µM 0.588053754420913 0.261587404858095 no 895 0.278248106266875 1426 1955036 SGTC_561 1550-0330 72.9 µM 0.587173590280204 0.261901517438003 no 896 0.278543563749984 1314 6812934 SGTC_1969 st069479 40.1 µM 0.586280367547633 0.262220487993849 no 897 0.278843560950036 1402 3895485 SGTC_2006 4011487 200 µM 0.585035545328425 0.262665346727913 no 898 0.27926190819042 1440 45595294 SGTC_1620 st003704 16.5 µM 0.583510899016087 0.263210731051379 no 899 0.27977471107961 1345 2834414 SGTC_619 1652-1634 108 µM 0.583348173318309 0.263268974135864 no 900 0.279829469568328 1344 5400454 SGTC_2218 6965428 192.983 µM 0.581615301494366 0.263889614844819 no 901 0.280412916921631 1372 675684 SGTC_3261 9137475 49.47 µM 0.576051587274923 0.265887329024866 no 902 0.282290156599214 1311 17027690 SGTC_2605 digitonin 300 nM 0.575259405960191 0.266172392631526 no 903 0.282557935628354 1421 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_251 melphalan 456.522 µM 0.575178798331436 0.266201407668994 no 904 0.282585190063172 1457 460612 A DNA alkylator. SGTC_79 0052-0007 94.094 µM 0.57503925653953 0.266251640078476 no 905 0.282632373853553 1426 2801472 SGTC_2183 6420625 130.508 µM 0.574906876917811 0.26629929867648 no 906 0.282677139372187 1363 2897619 SGTC_1664 st014217 9.02 µM 0.574309714875042 0.266514339389309 no 907 0.282879118146652 1412 3982782 SGTC_1116 jasmonic acid  1.58368 µM 0.574270471348433 0.266528474233013 no 908 0.282892393954428 1422 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_252 miconazole 1.30953 nM 0.572883806660306 0.267028170279797 no 909 0.283361684784769 1352 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2324 6149169 200 µM 0.572619411420451 0.267123500957195 no 910 0.283451206781288 1323 2888231 SGTC_743 1275-0778 158 µM 0.572419819034526 0.267195477615886 no 911 0.283518796057007 1428 2849257 YMR203W TOM40 SGTC_990 3985-0011 41.3 µM 0.572136762158747 0.26729756987569 no 912 0.283614662700509 1384 5399565 YGL099W LSG1 SGTC_1410 3909-8106 77.9 µM 0.571928757232599 0.26737260512654 no 913 0.283685120397661 1412 1039210 SGTC_2457 5731572 11.68 µM 0.57178101107375 0.267425909212434 no 914 0.283735171679681 1460 2865357 SGTC_1492 4158-0558 28.5 µM 0.569596605450352 0.268214627342196 no 915 0.284475665671069 1456 3967268 SGTC_2344 7990960 76.95 µM 0.569541315141275 0.268234606059516 no 916 0.284494420564791 1394 140813 SGTC_3329 9141233 27.5565 µM 0.567466687082238 0.268984797276125 no 917 0.285198576699426 1464 4909101 YNL103W MET4 SGTC_2856 9022925 19.48 µM 0.566581655935916 0.269305147152022 no 918 0.285499220469903 1407 4944862 SGTC_71 0417-1750 47.813 µM 0.56653528072122 0.269321938608379 no 919 0.285514978220856 1501 6811472 SGTC_3165 9101544 49.47 µM 0.56631196585927 0.269402803412043 no 920 0.285590863773382 1406 5002184 SGTC_1218 1348-1416 30.7 µM 0.565701493424852 0.269623924395089 no 921 0.285798359923801 1383 6787668 SGTC_404 fumagillin 50 µM 0.565463340730329 0.269710211018173 no 922 0.28587932612282 1394 12015870 A methionine aminopeptidase binder. SGTC_723 4182-0001 115 µM 0.56005521426599 0.271673379252582 no 923 0.287720888547266 1347 744821 YLR208W SEC13 SGTC_297 0986-0032 24 µM 0.559554874542711 0.27185536313634 no 924 0.287891545928835 1362 2847425 SGTC_1672 st016598 6.51 µM 0.558679372885216 0.272173947008679 no 925 0.288190279619772 1351 4665860 YNL267W PIK1 SGTC_1597 7-benzyloxygramine 47.5 µM 0.558177539716859 0.272356641321422 no 926 0.288361578183316 1391 260807 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.556638972769807 0.272917142009613 no 927 0.288887060282326 1449 688788 SGTC_2963 9082507 9 µM 0.556380535519939 0.273011346905805 no 928 0.288975371119289 1427 16459611 SGTC_916 4466-0038 42 nM 0.556270122194788 0.273051599407602 no 929 0.289013104432963 1436 5722064 YGL116W CDC20 SGTC_3202 9113761 49.47 µM 0.554367338293551 0.273745743928251 no 930 0.289663737098 1549 4798415 SGTC_3240 9133527 49.47 µM 0.552896683217556 0.274282843137844 no 931 0.290167079376617 1384 17617455 SGTC_726 3448-4391 34.2 µM 0.552406243523358 0.274462072667503 no 932 0.290335026966154 1514 1356692 SGTC_654 1124-0271 80.9 µM 0.552016252144666 0.274604634939886 no 933 0.290468609225671 1378 5403748 SGTC_1333 1482-0047 286 µM 0.551806025347443 0.274681498992641 no 934 0.290540629340145 1378 3811116 SGTC_681 1642-0006 26.6 µM 0.551016309478187 0.274970333160345 no 935 0.290811247150757 1394 4446530 SGTC_2914 7968218 45.32 µM 0.550327841081605 0.275222258662891 no 936 0.291047265841762 1463 2977111 SGTC_1415 3966-0071 78.1 µM 0.54826449199788 0.27597796270328 no 937 0.291755152443685 1402 2893185 SGTC_2769 toremifene 3.73 µM 0.548045865273325 0.276058094670229 no 938 0.291830205121433 1438 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1124 fisetin 1.16336 µM 0.547837432865268 0.276134500810163 no 939 0.291901766551803 1418 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_11 0438-0307 1.3 µM 0.545806750106559 0.276879441398839 no 940 0.29259939140335 1481 4011476 SGTC_2339 9000433 200 µM 0.544147067800124 0.277489013260841 no 941 0.293170136646981 1383 2988954 SGTC_2461 5755302 26.15 µM 0.543385970205711 0.277768770099811 no 942 0.293432041696274 1516 2788904 SGTC_1039 k821-0043 94 µM 0.5419872125739 0.278283270672788 no 943 0.293913657523271 1481 15992768 SGTC_1175 0741-0056 27.6 µM 0.541700588489441 0.278388756024336 no 944 0.294012392139347 1518 765927 SGTC_2581 avocatin a 64 µM 0.541006920601074 0.278644125031173 no 945 0.294251406301916 1435 6710728 A skin care supplement. SGTC_2645 abamectin 100 µM 0.540489608778156 0.278834644003237 no 946 0.29442971261794 1411 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.540285732241881 0.278909746394487 no 947 0.294499998197081 1396 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2126 5251174 33.877 µM 0.539848648006632 0.279070789112091 no 948 0.294650707240125 1541 790722 SGTC_1791 st048313 56.1 µM 0.538238879741851 0.279664294284663 no 949 0.295206070717298 1456 1204976 SGTC_2219 9098279 200 µM 0.537602399617633 0.279899126899806 no 950 0.295425786615134 1437 902349 SGTC_386 1509-0011 3.07 µM 0.537261912671355 0.280024790559087 no 951 0.29554335516776 1427 3107280 SGTC_826 1683-5028 118 µM 0.537140695927761 0.28006953467377 no 952 0.295585215935531 1447 722377 SGTC_2978 9011784 42.97 µM 0.536835466324157 0.280182217857885 no 953 0.295690635438484 1551 2994934 SGTC_714 4296-0578 26.1 µM 0.535766008153481 0.280577208463382 no 954 0.296060138715494 1440 1589775 SGTC_1583 clindamycin 39.6 µM 0.53406983201021 0.281204221307114 no 955 0.296646610441911 1367 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.533823464685935 0.281295350334134 no 956 0.296731838914531 1480 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_998 3996-0085 177 µM 0.530867086991909 0.282389998031404 no 957 0.297755443419497 1533 715391 SGTC_2109 5483026 200 µM 0.528846512177088 0.283139326129357 no 958 0.298455964558341 1472 759335 SGTC_584 0986-0246 15.4 µM 0.527693179789681 0.283567465540515 no 959 0.298856153852661 1511 53315 YDR232W HEM1 SGTC_1399 3562-5772 25 µM 0.527265168027604 0.283726430711553 no 960 0.299004729612961 1403 23847490 SGTC_2607 solasodine 47.35 µM 0.525738368174833 0.284293837268997 no 961 0.299535000808368 1443 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3190 9110366 49.47 µM 0.524963994019824 0.284581826071706 no 962 0.299804110663105 1477 17123768 SGTC_2898 9056270 58.44 µM 0.52465716218754 0.284695974978383 no 963 0.299910770877199 1422 19154699 SGTC_968 1309-0633 340 µM 0.523516563998337 0.285120496778126 no 964 0.300307413641907 1450 3761976 SGTC_3018 9082602 49.47 µM 0.523072314221997 0.285285924710255 no 965 0.300461965530647 1438 17332089 SGTC_2944 9067346 25.62 µM 0.52203172508335 0.285673593971749 no 966 0.300824120944087 1467 6473075 SGTC_70 0141-0289 43.283 µM 0.519764532118876 0.286519098723678 no 967 0.301613851363755 1557 352408 SGTC_1828 st055811 49 µM 0.516457968153269 0.287754340435856 no 968 0.302767294006811 1452 5877589 SGTC_1468 k284-1086 134 µM 0.516238239072734 0.287836514272506 no 969 0.302844012985527 1464 15996457 SGTC_2118 5526350 200 µM 0.514904934262593 0.28833537842579 no 970 0.303309726346999 1497 743594 SGTC_3323 9138564 53.9225 µM 0.514873610172518 0.28834710342551 no 971 0.303320671464187 1570 43912313 YNL103W MET4 SGTC_2199 6590217 200 µM 0.511792033838493 0.289501673445286 no 972 0.304398283101277 1487 703109 SGTC_465 cgp-37157 41 µM 0.506732981076375 0.291401835629644 no 973 0.306171092981549 1465 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2670 beta-carotene 100 µM 0.506481587407954 0.291496409762593 no 974 0.306259306136869 1430 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_87 0100-0052 35.5 µM 0.504874328770447 0.292101397479924 no 975 0.306823552846982 1536 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_984 1492-0255 2.91 µM 0.504503211835249 0.292241172491804 no 976 0.306953902866125 1504 1585198 SGTC_851 0394-0702 453 µM 0.503867905593735 0.292480522200447 no 977 0.307177102606695 1538 762646 SGTC_737 1950-0117 57.9 µM 0.50386509127776 0.292481582688176 no 978 0.307178091508718 1492 5393513 SGTC_1838 st055369 84.5 µM 0.503799814196834 0.292506180833965 no 979 0.307201029140933 1438 676036 SGTC_246 cycloheximide 667 µM 0.503379087966031 0.292664744767371 no 980 0.307348885703608 1419 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3125 9127534 49.47 µM 0.501149510288791 0.293505697018809 no 981 0.308132952379839 1426 1639235 SGTC_2980 9014342 25.29 µM 0.499602193681037 0.294089971037363 no 982 0.308677606463463 1478 2996599 SGTC_3150 9097574 49.47 µM 0.499035575202219 0.294304063225584 no 983 0.308877161083391 1584 17217476 SGTC_365 0121-0052 13.6 µM 0.496082249305812 0.295421116947897 no 984 0.309918191195717 1522 3101739 SGTC_2430 5571206 200 µM 0.495421707191616 0.295671224297 no 985 0.310151237537166 1549 1731771 SGTC_937 3122-0005 46.7 µM 0.494760061609297 0.295921846979432 no 986 0.310384749661371 1562 759535 SGTC_2288 7946289 167.31 µM 0.492069936847589 0.29694183414971 no 987 0.311334951961358 1624 1246052 SGTC_1006 4099-6547 255 µM 0.491704022293561 0.297080698422976 no 988 0.311464297175601 1522 3146833 SGTC_3026 9090633 49.47 µM 0.491033745281162 0.297335144988377 no 989 0.311701290231546 1466 25236842 SGTC_975 1335-0046 28.5 µM 0.489925602278475 0.297756029856861 no 990 0.312093272731383 1422 16486740 SGTC_303 1348-1668 34.2 µM 0.488840633026908 0.298168376191353 no 991 0.312477264239312 1509 5380509 SGTC_1181 1222-0449 220 µM 0.487535447641193 0.298664760787526 no 992 0.312939464378534 1557 658318 SGTC_800 3448-7362 155 µM 0.486315550584946 0.299129048166784 no 993 0.313371727704196 1557 15991913 SGTC_1198 1612-1005 86.7 µM 0.485626799054024 0.299391328544568 no 994 0.313615896077915 1568 6998509 SGTC_1671 st016596 74.5 µM 0.485155249714029 0.299570957250008 no 995 0.313783111507363 1498 2829167 SGTC_2862 9027634 71.43 µM 0.483836683495758 0.300073501669044 no 996 0.314250889340408 1434 5012562 SGTC_1707 st032323 6.317 µM 0.483252287458086 0.300296354105521 no 997 0.314458306643489 1495 3132057 YMR211W DML1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.482650658918564 0.300525856063097 no 998 0.314671901409562 1482 115019 SGTC_3315 9136395 68.55 µM 0.482525299652586 0.30057368656527 no 999 0.314716415226329 1559 16876844 SGTC_2561 acetosyringone 100 µM 0.482445355284696 0.300604190925899 no 1000 0.314744804074907 1464 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2278 7948257 134.34 µM 0.48061105448767 0.301304488384568 no 1001 0.315396478639912 1592 1247028 SGTC_60 0986-0278 202 µM 0.480399537807529 0.30138528822331 no 1002 0.315471661453103 1329 3110598 SGTC_923 1900-2434 73.3 µM 0.479128350729007 0.301871089816667 no 1003 0.315923660985014 1461 5910570 SGTC_1910 st062352 60.4 µM 0.478345143839962 0.302170578158431 no 1004 0.316202285178671 1397 2245730 SGTC_2424 5537928 59.2 µM 0.476146749131325 0.303011927961525 no 1005 0.316984916835406 1497 5382802 SGTC_1977 st070720 65.3 µM 0.473427846239736 0.304053929242596 no 1006 0.317953983559692 1506 682188 SGTC_655 k060-0012 42 µM 0.473234368879463 0.304128138976862 no 1007 0.318022990066474 1474 5994525 SGTC_1397 3532-0190 20.1 µM 0.472334164120011 0.30447352553856 no 1008 0.318344144210459 1536 5322280 SGTC_274 sirtinol 40.1 µM 0.471910191029971 0.304636254092118 no 1009 0.318495446805463 1475 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_474 dl-dihydrosphingosine 5 µM 0.467839937245484 0.306200455026446 no 1010 0.319949529124942 1565 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2281 7943571 200 µM 0.467616332244562 0.306286489375476 no 1011 0.320029491624373 1606 1244024 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.46705948947951 0.306500786836064 no 1012 0.320228658293274 1495 91467 include heat shock SGTC_575 k072-0246 11.9 µM 0.466345514990993 0.306775652290811 no 1013 0.320484102257813 1547 6796779 SGTC_482 fipronil 114 µM 0.465912041422732 0.306942583708978 no 1014 0.320639230828785 1564 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1718 roemerine 11.9335 µM 0.465888820636008 0.306951527203971 no 1015 0.320647541810329 1491 235224 An aporphine alkaloid with mutagenic activity. SGTC_1575 cyproterone acetate 48 µM 0.465806153195074 0.306983367533309 no 1016 0.32067713014988 1466 9880 An androgen receptor antagonist and liver toxin. SGTC_466 geldanamycin 89.2 µM 0.465436031993323 0.307125941879906 no 1017 0.320809617939278 1529 5288382 HSP90 inhibitor. SGTC_3114 9122766 49.47 µM 0.464338037929084 0.307549071578834 no 1018 0.321202787773183 1465 17176985 SGTC_3154 9100113 49.47 µM 0.46251050010163 0.308253910617182 no 1019 0.321857637131178 1489 25237525 SGTC_634 1611-4317 11.2 µM 0.460733338747365 0.308939999322632 no 1020 0.322494966503869 1575 2843522 SGTC_2683 piperine 63.03 µM 0.458765860003295 0.309700339901019 no 1021 0.323201156748314 1535 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3356 9151811 4.48 µM 0.458242495837633 0.309902733590242 no 1022 0.323389116140485 1512 1859254 YPR165W RHO1 SGTC_3179 9107801 49.47 µM 0.456807729687783 0.310457877094559 no 1023 0.323904624715514 1506 4818259 SGTC_628 1636-0253 16 µM 0.455355103821016 0.311020371101859 no 1024 0.324426894565363 1616 4456143 SGTC_2955 9076254 12.21 µM 0.453519839283858 0.311731664206324 no 1025 0.325087230409069 1622 16459619 SGTC_678 1218-2179 85.9 µM 0.453320047173047 0.311809140067817 no 1026 0.325159149663468 1577 6820081 YOR116C RPO31 SGTC_2972 9093619 59.92 µM 0.452896500303372 0.311973411625133 no 1027 0.325311635556514 1479 25236256 SGTC_7 0192-1582 4.227 µM 0.452725457724766 0.31203976065105 no 1028 0.325373222820622 1566 252616 SGTC_534 k292-0788 63.4 µM 0.452214435213832 0.312238027413462 no 1029 0.325557254989623 1666 4146317 SGTC_2 0422-0095 29 µM 0.451732686464046 0.312424986333296 no 1030 0.325730783883596 1494 6790840 SGTC_2338 7999974 200 µM 0.45000500104659 0.313095870078851 no 1031 0.326353417277813 1672 315925 SGTC_1805 st050013 60.3 µM 0.44940919494757 0.313327373400426 no 1032 0.326568249743481 1585 4037144 SGTC_987 1497-1013 404 µM 0.448699186050293 0.313603346847537 no 1033 0.326824335946503 1583 1676435 SGTC_2187 6125751 200 µM 0.448678103899438 0.313611542867424 no 1034 0.326831941110335 1565 874498 SGTC_2889 9059656 51.95 µM 0.447462051421271 0.314084458129361 no 1035 0.327270740895272 1615 3949838 SGTC_1935 st074532 41.6 µM 0.447220393481625 0.314178473808207 no 1036 0.327357969091852 1699 2829742 SGTC_1076 itraconazole 331 nM 0.446908857911968 0.314299692783407 no 1037 0.327470434039182 1550 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2471 5466956 24.79 µM 0.445987804994981 0.314658193015606 no 1038 0.327803027489029 1587 724419 SGTC_1493 4348-0038 111 µM 0.445731359360312 0.314758040139196 no 1039 0.32789565468325 1614 800424 SGTC_3149 9097855 49.47 µM 0.445047918198894 0.315024204130095 no 1040 0.328142562746614 1690 25236625 YMR079W SEC14 SGTC_3010 9080089 71.4286 µM 0.444672408249672 0.315170486195537 no 1041 0.32827825590474 1641 17027233 SGTC_2397 5161689 200 µM 0.444343885819251 0.315298487776795 no 1042 0.328396988377444 1636 2259942 SGTC_713 1488-1073 324 µM 0.443385411292887 0.315672063092626 no 1043 0.328743493121019 1584 3312542 SGTC_1301 naphtanilide LB 4.81 µM 0.443334745743541 0.315691815758542 no 1044 0.328761813674427 1660 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3118 9124250 49.47 µM 0.443044985163494 0.315804793046702 no 1045 0.328866598380992 1538 1504786 SGTC_2038 4100038 30.985 µM 0.442176079137107 0.316143681575035 no 1046 0.329180897260698 1594 3596803 SGTC_2525 harmine 47.85 µM 0.441771088865605 0.316301687667559 no 1047 0.329327430777021 1636 5280953 A monoamine oxidase inhibitor SGTC_2418 pentamidine 31.67 µM 0.440901853463508 0.316640931247572 no 1048 0.329642025896827 1495 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_39 0986-0283 58.349 µM 0.440790159554863 0.31668453413131 no 1049 0.32968245908904 1707 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3157 9099274 49.47 µM 0.440742550814534 0.316703120327075 no 1050 0.32969969405701 1623 17217662 SGTC_2322 7413319 38.22 µM 0.440482059422519 0.316804822954831 no 1051 0.329794001647496 1601 1840400 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.440231852505203 0.316902523293331 no 1052 0.329884596064181 1598 66535 A nucleotide analog. SGTC_2425 5628681 7.85 µM 0.437713065743197 0.317886764875357 no 1053 0.330797148423951 1658 5714958 SGTC_1089 terbinafine 2.25 µM 0.436964021820224 0.318179710195107 no 1054 0.331068720226604 1628 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2990 9074105 71.4286 µM 0.435589726087239 0.318717482449019 no 1055 0.331567213119537 1583 6502001 SGTC_1524 corynanthine 62.1 µM 0.434156713861482 0.319278637769976 no 1056 0.332087321907888 1621 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2161 5662504 8.5105 µM 0.433975381550204 0.319349675503357 no 1057 0.332153159179816 1557 2859334 SGTC_2846 9008642 19.48 µM 0.433175612795637 0.319663067541251 no 1058 0.332443597205951 1561 2992898 SGTC_1590 st077108 57.8 µM 0.431180606574433 0.320445378380047 no 1059 0.333168527004375 1657 5489485 SGTC_3195 9113082 49.47 µM 0.429449391954333 0.321124894740947 no 1060 0.333798107929247 1671 17018038 SGTC_2740 felodipine 17.08 µM 0.429218894139223 0.321215412343503 no 1061 0.33388196710772 1685 3333 L-type calcium channel blocker SGTC_179 1273-0063 6.77 µM 0.428789368798532 0.321384117351116 no 1062 0.334038258150551 1530 3108139 SGTC_940 3232-1287 54.8 µM 0.428629814764513 0.321446794905173 no 1063 0.334096322283782 1593 1585493 YIL048W NEO1 SGTC_2189 6047310 154.431 µM 0.427874305777362 0.321743650240187 no 1064 0.334371317365016 1555 711535 SGTC_703 3875-0075 71.8 µM 0.427458434789104 0.321907103265315 no 1065 0.334522726743863 1642 2850814 SGTC_1450 4112-4260 37.6 µM 0.425525826903206 0.322667143059148 no 1066 0.335226699162036 1679 1633175 SGTC_2249 haloperidol 116.36 µM 0.425106053620461 0.322832326098595 no 1067 0.335379682558981 1642 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2919 7978188 46.38 µM 0.425004019678469 0.322872482285126 no 1068 0.335416872231301 1714 2980291 SGTC_2534 helenine 20.12 µM 0.424173701110451 0.323199336834956 no 1069 0.335719569452853 1591 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1790 st045711 43.5 µM 0.42399856885607 0.323268295016924 no 1070 0.33578342850654 1715 585119 SGTC_3324 9138759 60.749 µM 0.419590714831742 0.325005878423037 no 1071 0.337392236288449 1603 45595710 SGTC_1317 1273-0028 910 nM 0.419104981508266 0.325197589237959 no 1072 0.337569705103918 1587 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1210 3013-0140 750 nM 0.418904591304106 0.325276693385697 no 1073 0.337642930730271 1730 905973 SGTC_3086 9117350 49.47 µM 0.417219411507213 0.32594223029994 no 1074 0.33825896401278 1539 2679265 SGTC_3333 9141820 12.094 µM 0.415929608997552 0.326451993848461 no 1075 0.338730756215683 1586 1939433 SGTC_197 4544-0043 41.561 µM 0.414938880087084 0.326843776000677 no 1076 0.339093323320029 1595 896523 SGTC_1266 0828-0227 32.9 µM 0.414419304158446 0.327049317832552 no 1077 0.339283526912875 1653 3913820 SGTC_2623 humulene 100 µM 0.412391325463737 0.327852078442052 no 1078 0.340026310108828 1565 6187145 An anti-inflammatory. SGTC_2438 5259590 200 µM 0.410927288917328 0.328432101742256 no 1079 0.340562925895637 1729 1201127 SGTC_263 alizarin 107.927 µM 0.410648695367223 0.328542522080335 no 1080 0.340665075861476 1643 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_324 1315-0088 19.6 µM 0.410524389887585 0.328591795293038 no 1081 0.34071065786109 1638 6787421 SGTC_1837 st055472 66.5 µM 0.410519881179681 0.328593582547211 no 1082 0.340712311218264 1666 676091 SGTC_3339 9145883 14.936 µM 0.409666229067116 0.328932041305346 no 1083 0.341025403204489 1681 2030670 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.408172135025042 0.329524762149616 no 1084 0.34157365203317 1584 279621 SGTC_1529 apigenin 74 µM 0.405731198357785 0.330494025644415 no 1085 0.342470058140239 1712 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3242 9133940 49.47 µM 0.404950523121139 0.330804261920581 no 1086 0.342756939879376 1652 17248444 SGTC_1958 st076513 41.9 µM 0.404588365957908 0.330948220778139 no 1087 0.342890055833084 1576 732122 YGL099W LSG1 SGTC_2845 9003024 42.97 µM 0.402550936711043 0.331758572116364 no 1088 0.343639304711542 1700 2990173 SGTC_2088 5278280 127.392 µM 0.40130376066748 0.332255003273107 no 1089 0.344098247576468 1643 791502 SGTC_1825 st052143 62.6 µM 0.39956115356196 0.332949130937127 no 1090 0.344739886609375 1691 674173 SGTC_2584 androsterone 48.74 µM 0.398559721424836 0.333348287860906 no 1091 0.345108822616603 1644 2754130 A steroid. SGTC_935 2996-0153 430 µM 0.397945725021166 0.333593111683131 no 1092 0.345335096900444 1771 23738523 SGTC_3345 9148410 3.559 µM 0.397821479905387 0.333642661583472 no 1093 0.345380891315436 1722 4903596 SGTC_1230 0170-0365 3.77 µM 0.397747448252831 0.333672187351189 no 1094 0.345408179067677 1699 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.397636266952522 0.333716531309409 no 1095 0.34544916153154 1579 23665772 A membrane-active detergent. SGTC_1693 xanthone 101.9 µM 0.396582991290184 0.334136738802604 no 1096 0.345837498587931 1664 7020 An insecticide. SGTC_206 4546-0025 72.014 µM 0.395823394588663 0.334439911313594 no 1097 0.346117658512143 1631 6620745 YIL048W NEO1 SGTC_2291 7917025 104.35 µM 0.394353499393432 0.335026886871071 no 1098 0.346660034969887 1571 2964612 SGTC_1435 4092-0789 56.7 µM 0.392846948078952 0.335628918784537 no 1099 0.347216263502041 1730 2248285 SGTC_1494 4358-1428 177 µM 0.392654646086292 0.335705794864162 no 1100 0.347287286368356 1785 1564571 SGTC_1012 4112-3522 18 µM 0.388915601104005 0.337201906664315 no 1101 0.348669290470092 1759 3112398 SGTC_1976 st070609 63.5 µM 0.388056236230447 0.337546131354492 no 1102 0.348987208754808 1618 682556 SGTC_1997 st073024 93.8 µM 0.387616161760798 0.337722458966315 no 1103 0.349150053451095 1727 686268 SGTC_1648 st011736 69.8 µM 0.387173833213105 0.337899725635474 no 1104 0.349313760238233 1717 2855514 SGTC_63 0099-0242 26.702 µM 0.384432611902272 0.338999092379156 no 1105 0.350328916640986 1687 3898502 YLR359W ADE13 SGTC_2007 4011539 71.82 µM 0.383824067433931 0.339243335619315 no 1106 0.350554424306405 1596 45595301 SGTC_1471 k673-0312 37 µM 0.383739925903744 0.339277111683058 no 1107 0.350585608689269 1665 24099884 SGTC_244 nsc-207895 1.295 µM 0.383376757813179 0.339422909304942 no 1108 0.350720216944619 1600 42640 SGTC_492 tmb-8 126 µM 0.382247311686606 0.33987649079624 no 1109 0.35113896587655 1727 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2002 4023503 131 µM 0.381604678514445 0.340134673523952 no 1110 0.351377306725211 1828 4736863 YCR052W RSC6 SGTC_1932 st074806 40.9 µM 0.37935400603606 0.341039488627166 no 1111 0.352212500155582 1719 17251235 SGTC_1285 0929-0069 65.5 µM 0.379243592597164 0.34108390061118 no 1112 0.352253491442599 1664 1206237 SGTC_3205 9113483 49.47 µM 0.378986716818474 0.34118723317398 no 1113 0.352348863909588 1766 17018033 SGTC_3024 9090631 49.47 µM 0.378112949847796 0.341538809621576 no 1114 0.352673344320571 1783 25236383 SGTC_1201 1889-3372 45.9 µM 0.376951773883044 0.342006243243022 no 1115 0.353104722266175 1659 5392199 SGTC_2829 7992743 58.44 µM 0.374826086702974 0.342862569979454 no 1116 0.353894905981212 1853 16462845 SGTC_298 1391-0729 10 µM 0.373993385994238 0.343198241455273 no 1117 0.354204618466713 1659 3237558 SGTC_2223 6903751 107.57 µM 0.371639835782314 0.34414765377469 no 1118 0.355080512704924 1741 5598863 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.37112397218907 0.34435588257092 no 1119 0.355272598394874 1727 1377 SGTC_1077 5-fluorocytosine 377 nM 0.370353808977551 0.344666847430744 no 1120 0.35555944288951 1686 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3264 9137442 49.47 µM 0.370241654120069 0.344712140386252 no 1121 0.3556012213887 1753 17015726 SGTC_1250 0485-0349 40.2 µM 0.370087035676923 0.344774585613684 no 1122 0.355658820726422 1638 6842794 YDL195W SEC31 SGTC_339 3091-4833 71.4 µM 0.369941146857664 0.34483350911518 no 1123 0.355713171077431 1708 3240077 SGTC_2194 5927483 104.545 µM 0.369701887930656 0.344930152315252 no 1124 0.355802312473548 1698 760979 SGTC_336 4111-0029 111 µM 0.369269879697867 0.345104677835297 no 1125 0.355963287010413 1636 3131175 SGTC_576 1073-0113 22.7 µM 0.3691382790221 0.345157849289237 no 1126 0.356012329045729 1737 5439563 SGTC_2466 5983409 37.09 µM 0.368721028138564 0.345326454011496 no 1127 0.356167836644318 1663 2879657 SGTC_1216 1165-0504 9.65 µM 0.36848789384402 0.345420673397459 no 1128 0.356254735207629 1783 6304004 SGTC_3354 9151612 71.43 µM 0.368177355761771 0.345546189790624 no 1129 0.356370496881733 1782 27261949 SGTC_572 0960-0087 17.7 µM 0.36806988878147 0.34558963082778 no 1130 0.356410561259565 1596 6796365 SGTC_1740 st038286 13.222 µM 0.367673183235871 0.345750007458617 no 1131 0.356558469344688 1703 716786 SGTC_939 1165-0479 45.3 µM 0.367356569304092 0.34587802522177 no 1132 0.356676531475934 1750 1377347 SGTC_614 0462-0418 107 µM 0.366553096367862 0.346202975680543 no 1133 0.356976200023106 1617 5188303 SGTC_2569 tetrandrine 100 µM 0.366404539421989 0.346263069330914 no 1134 0.357031616472084 1610 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_25 0118-0223 35.662 µM 0.365647705632577 0.34656928071504 no 1135 0.35731398626927 1726 5333628 SGTC_2795 7780010 54.55 µM 0.363810108453431 0.347313180873688 no 1136 0.357999906866326 1686 953673 SGTC_742 0kpi-0133 140 µM 0.363350589287913 0.347499296546237 no 1137 0.358171503535173 1809 2728852 SGTC_718 1130-0073 349 µM 0.361399135726812 0.348290088615556 no 1138 0.358900546996739 1754 6740020 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.360923002511869 0.348483133477151 no 1139 0.35907850373514 1786 165506 SGTC_3321 9137793 26.8275 µM 0.360790930752541 0.348536687998204 no 1140 0.359127871515754 1679 4904192 SGTC_1066 ketoconazole 628 nM 0.360724193308445 0.348563750888317 no 1141 0.359152818542173 1758 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2188 6126565 140.678 µM 0.360102205539053 0.348816011961246 no 1142 0.359385351750142 1746 874518 SGTC_2930 9013230 14.89 µM 0.358605879662523 0.349423154101533 no 1143 0.359944973824285 1785 2995857 SGTC_310 1273-0058 1.06 µM 0.358134150171542 0.349614640826564 no 1144 0.360121461779896 1702 2734232 SGTC_744 1594-0068 283 µM 0.357009061296769 0.350071496768915 no 1145 0.360542511112121 1681 668392 SGTC_2101 5377231 179.231 µM 0.356971095795294 0.350086916909831 no 1146 0.360556722141787 1774 2844213 SGTC_902 1120-0002 2.07 µM 0.356329666923327 0.35034747824033 no 1147 0.360796847233925 1638 3280475 SGTC_1504 k297-0033 30 µM 0.355674714609955 0.350613605756916 no 1148 0.361042091593681 1633 4388117 SGTC_1000 4048-0884 8.67 µM 0.354814017006677 0.350963445479552 no 1149 0.361364463345104 1726 13040088 SGTC_1276 0871-0068 94.2 µM 0.354020508205835 0.351286087568229 no 1150 0.361661756967167 1764 3414906 SGTC_1104 tacrolimus 29.8 µM 0.353661501539293 0.35143209555414 no 1151 0.361796288779205 1718 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2676 harmalol 100 µM 0.353433993304615 0.351524634488227 no 1152 0.361881552571897 1767 5459187 A monoamine oxidase inhibitor SGTC_2973 9094665 17.96 µM 0.353257003320143 0.351596631219349 no 1153 0.361947888263759 1820 25237061 YIL048W NEO1 SGTC_2225 6654152 15.4 µM 0.353225299037631 0.35160952858318 no 1154 0.361959771439281 1753 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_963 1269-2853 151 µM 0.352902217711668 0.351740968432356 no 1155 0.362080874088783 1638 3668223 SGTC_2881 9058953 51.95 µM 0.352743051499865 0.351805728871569 no 1156 0.362140540460484 1637 17122249 SGTC_391 gliotoxin 8.33 µM 0.352624845292752 0.351853826572089 no 1157 0.362184854391601 1746 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_102 gallobenzophenone 83.616 µM 0.351587473772273 0.352276031116065 no 1158 0.362573830320583 1791 70837 SGTC_2731 amoxapine 43.43 µM 0.347790345216978 0.353822991624717 no 1159 0.363998820483576 1801 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3192 9110362 49.47 µM 0.347765688964887 0.353833044572906 no 1160 0.364008079679347 1733 16649480 SGTC_36 0335-0881 14.2 µM 0.347201815762771 0.354062977070695 no 1161 0.364219853407225 1728 23828853 SGTC_261 5-fluorouridine 15.376 µM 0.345754082260751 0.354653567879418 no 1162 0.364763768097828 1783 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2167 5876490 200 µM 0.345297927849326 0.354839724755641 no 1163 0.364935202161246 1860 686534 SGTC_224 benfluorex 43.875 µM 0.343881706152553 0.355417906349206 no 1164 0.365467625088563 1814 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_133 0724-0033 378.92 µM 0.342276539142572 0.35607362855579 no 1165 0.366071394777849 1709 280309 SGTC_3008 9078912 71.4286 µM 0.34067349081592 0.356728910384195 no 1166 0.366674698695462 1690 16648731 SGTC_1045 1348-1485 165 µM 0.340626601281364 0.35674808390656 no 1167 0.366692350442249 1705 6810614 SGTC_2274 7947094 46.08 µM 0.340057240497358 0.356980929154354 no 1168 0.366906710999297 1660 2971028 SGTC_393 acivicin 6.25 µM 0.338917845359521 0.357447055051862 no 1169 0.367335810291614 1721 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1482 3346-2049 8.48 µM 0.338776367760042 0.357504948319455 no 1170 0.367389102715614 1783 3826804 SGTC_1603 st002045 67.8 µM 0.338594162206891 0.357579512479174 no 1171 0.367457740492999 1829 5887985 SGTC_1348 1493-0373 93.8 µM 0.337970981175545 0.357834578551134 no 1172 0.367692528018863 1747 3010129 SGTC_1017 4239-0030 168 µM 0.337849420652927 0.35788434030137 no 1173 0.367738332507047 1633 1149593 SGTC_2854 9024559 71.43 µM 0.337703809449912 0.357943950564696 no 1174 0.367793201863464 1662 3163529 SGTC_898 1000-0849 28.3 µM 0.336744245829694 0.358336862950755 no 1175 0.368154852997576 1798 6751807 SGTC_3005 9076496 71.4286 µM 0.336066132049944 0.358614620619887 no 1176 0.368410498649851 1782 21368410 SGTC_1282 0886-0010 32.4 µM 0.336047005853639 0.358622455859084 no 1177 0.36841770997976 1869 2836211 YNL267W PIK1 SGTC_1924 st058459 75.1 µM 0.335551076303459 0.358825639167028 no 1178 0.36860471114357 1745 688683 SGTC_1720 st037298 9.481 µM 0.333289008878331 0.359752918593388 no 1179 0.369458067611225 1695 597396 SGTC_2333 9017922 200 µM 0.333118930257396 0.359822671641576 no 1180 0.369522255197339 1852 3163164 SGTC_2575 plumbagin 510 nM 0.332441638165833 0.360100490581297 no 1181 0.369777900953387 1650 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_290 2043-6722 48.1 µM 0.332395621340392 0.360119368939575 no 1182 0.369795272219946 1752 773758 YLR208W SEC13 SGTC_430 0958-0115 16.4 µM 0.331379242600139 0.360536424240889 no 1183 0.370179021003597 1719 6833180 SGTC_2847 9005661 71.43 µM 0.331149666798853 0.360630650115675 no 1184 0.370265718643254 1754 2991449 SGTC_450 aminopyrene 156 nM 0.330922283444686 0.360723984475832 no 1185 0.370351594818366 1809 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3148 9097893 49.47 µM 0.329781428566261 0.361192397895832 no 1186 0.370782560472358 1592 17174100 SGTC_3186 9110464 49.47 µM 0.329020866612816 0.361504785951657 no 1187 0.37106995802548 1795 17018021 SGTC_2196 6573537 42.6665 µM 0.328780421731304 0.361603563872144 no 1188 0.37116083117095 1830 2903087 SGTC_525 k781-2675 26.7 µM 0.328437886361108 0.361744297836618 no 1189 0.371290300549925 1751 3651118 YDL195W SEC31 SGTC_754 3474-0146 171 µM 0.328061349600162 0.361899023178779 no 1190 0.371432638368568 1630 24762078 SGTC_1061 3448-9325 110 µM 0.327491413165127 0.362133262667319 no 1191 0.371648118264261 1815 723482 SGTC_615 k087-0205 167 µM 0.327374588836196 0.362181282947777 no 1192 0.371692291833339 1661 9642773 SGTC_524 r073-0010 27.8 µM 0.32696241696469 0.362350722247849 no 1193 0.371848155590176 1702 2772106 SGTC_2054 5233173 129 µM 0.322760402105992 0.364079657852204 no 1194 0.373438351908967 1779 6889 SGTC_660 4031-1742 102 µM 0.322466127985787 0.364200842297334 no 1195 0.373549797167865 1734 6738706 SGTC_2348 9022543 33.42 µM 0.321773718589913 0.364486035588957 no 1196 0.373812062896084 1770 3162678 YDL140C RPO21 SGTC_1785 bathophenanthroline 24 µM 0.321664431488595 0.364531056205473 no 1197 0.373853463201633 1689 72812 An iron chelator. SGTC_2137 5261020 140 µM 0.318774843878848 0.365722092534414 no 1198 0.374948627770019 1759 763655 SGTC_120 rhodamine 6G 52.259 µM 0.318422501499572 0.36586741060851 no 1199 0.375082236055505 1708 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_908 3448-7491 47.7 µM 0.317936442406368 0.366067909624957 no 1200 0.375266574340903 1698 1203031 SGTC_1941 st076221 61.8 µM 0.314964584892151 0.367294592317882 no 1201 0.376394271741083 1889 2828568 SGTC_866 0495-0101 262 µM 0.314850936037643 0.36734152972829 no 1202 0.37643741781768 1672 635694 SGTC_651 3253-0966 34.4 µM 0.313585920277975 0.367864119745991 no 1203 0.376917777257067 1745 781462 SGTC_986 1493-0483 84 µM 0.312132577653699 0.368464811388444 no 1204 0.377469884535882 1861 40079 SGTC_2736 butenafine 14.65 µM 0.311819016910647 0.368594453695949 no 1205 0.377589035359158 1832 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1009 4106-0057 9.87 µM 0.311803235698611 0.368600978864659 no 1206 0.377595032414056 1887 2928005 SGTC_3133 9127736 49.47 µM 0.310734092266467 0.369043133259059 no 1207 0.378001388733721 1938 27243420 SGTC_784 4579-0127 173 µM 0.310618959008188 0.369090758057585 no 1208 0.378045156242773 1896 1948547 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.308821943329443 0.369834352491261 no 1209 0.378728488068983 1790 688801 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.304841776253091 0.371483052234773 no 1210 0.380243331020424 1840 5377381 SGTC_955 1216-0110 33 µM 0.303222431091919 0.372154508933195 no 1211 0.380860177843712 1704 3619719 SGTC_768 0384-0033 77.3 µM 0.302853251360947 0.372307642733656 no 1212 0.381000849584446 1713 3965305 YMR134W ERG29 SGTC_2512 diallyl trisulfide 49.23 µM 0.301784735140035 0.372750971336049 no 1213 0.381408084127528 1814 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_540 1187-0821 17.3 µM 0.301541197622889 0.372852038945381 no 1214 0.381500919914143 1721 847520 SGTC_2834 9001755 58.44 µM 0.300993587763124 0.37307932796046 no 1215 0.381709692078186 1759 2989575 SGTC_1792 st045773 43.6 µM 0.300083254080723 0.373457265579588 no 1216 0.382056826115629 1775 2919270 SGTC_3011 9081274 71.4286 µM 0.299805262738561 0.373572701813695 no 1217 0.382162850398832 1762 6625322 SGTC_747 3448-8087 38.7 µM 0.299359403672931 0.373757869003669 no 1218 0.382332916905767 1744 5168703 SGTC_2477 5967686 25.23 µM 0.299051406979264 0.373885798378591 no 1219 0.382450411059158 1734 776118 SGTC_793 0488-0545 106 µM 0.298807810076793 0.373986988524326 no 1220 0.382543345734367 1739 292548 SGTC_3155 9099265 49.47 µM 0.296111512509171 0.375107609061022 no 1221 0.383572461163243 1831 25236499 SGTC_1299 1079-1439 3.74 µM 0.296015423089926 0.375147564747817 no 1222 0.38360915151723 1740 323161 SGTC_1802 st050112 57.9 µM 0.295081084829175 0.375536148977029 no 1223 0.383965969423291 1824 4662563 SGTC_1295 1013-0063 9.78 µM 0.29447999634974 0.375786203926349 no 1224 0.38419557336076 1912 6826038 SGTC_1430 4049-0248 69.1 µM 0.293899771609857 0.376027628978457 no 1225 0.384417246316004 1909 22774488 SGTC_2857 9024691 58.44 µM 0.292779865394574 0.376493746634676 no 1226 0.384845209647957 1789 16478292 SGTC_904 1141-0088 396 µM 0.29188400892117 0.376866741979939 no 1227 0.385187655198889 1738 1378119 SGTC_2268 7933382 153.85 µM 0.291826061963428 0.376890872513675 no 1228 0.385209808795449 1881 935025 YOR257W CDC31 SGTC_1733 st037357 54.9 µM 0.290092134424568 0.377613144538337 no 1229 0.385872876512137 1672 1272339 YGL099W LSG1 SGTC_501 nsc-95397 161 µM 0.289974257070546 0.377662262228635 no 1230 0.385917965883485 1888 262093 SGTC_2480 5767542 37.17 µM 0.289347374825488 0.377923507689631 no 1231 0.386157781046788 1844 2867358 SGTC_1324 1418-0026 34.4 µM 0.287746654907266 0.378590841092815 no 1232 0.386770337088526 1842 1372513 SGTC_2263 7948595 193.29 µM 0.287391475376707 0.378738963115403 no 1233 0.386906293843887 1768 2971371 SGTC_635 k038-0028 24.7 µM 0.287343102451903 0.378759137659646 no 1234 0.386924811260721 1849 4035102 SGTC_1267 0828-0272 9.49 µM 0.286448750083544 0.37913219816832 no 1235 0.387267220506077 1907 745334 SGTC_183 3914-0051 30.55 µM 0.285467240526715 0.379541744076171 no 1236 0.387643099472226 1951 1596232 SGTC_1406 3909-7906 11.9 µM 0.283512977407651 0.3803575845009 no 1237 0.388391817531409 1848 X1406 SGTC_3178 9107506 49.47 µM 0.281649403590532 0.381136061245454 no 1238 0.389106177218733 1843 8897194 SGTC_2551 apiole 73.87 µM 0.281399409034563 0.381240528963947 no 1239 0.389202035667395 1856 10659 A possible DNA adduct former. SGTC_3303 9125618 40.5795 µM 0.281171418698688 0.381335809105296 no 1240 0.389289462650336 1879 22695467 SGTC_1698 5-fluorocytosine 1.055 µM 0.280461142608465 0.381632688852112 no 1241 0.38956186666427 1927 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1047 2043-3044 82 µM 0.280451050804197 0.381636907506008 no 1242 0.389565737449126 1752 669592 SGTC_2797 7859098 81.82 µM 0.279459518142174 0.38205146411757 no 1243 0.38994610036466 1787 972681 SGTC_925 2064-1272 59.6 µM 0.278822708379521 0.382317783595062 no 1244 0.390190443257148 1766 6815817 SGTC_1691 st019933 84.6 µM 0.276180232888942 0.383423483798466 no 1245 0.391204819443458 1959 6176082 SGTC_919 tnp00227 403.569 nM 0.275793753621525 0.383585279520327 no 1246 0.391353240806404 1819 1269246 A methoxyflavone. YNL221C POP1 SGTC_2132 5317594 122.667 µM 0.275230776552356 0.383821000618394 no 1247 0.391569471712863 1852 794577 SGTC_3020 9089140 49.47 µM 0.274863159235819 0.383974946895419 no 1248 0.391710686005234 1796 17217859 SGTC_33 0986-0033 35.816 µM 0.274591342738203 0.384088786654654 no 1249 0.391815109127674 1867 2848082 SGTC_2730 imipramine 71.33 µM 0.271413018616819 0.385420643718909 no 1250 0.393036695151467 1930 3696 A tricyclic antidepressant. SGTC_892 0929-0076 29 µM 0.270936347700382 0.385620506720992 no 1251 0.393219994381413 1802 5751038 SGTC_3059 1327-0034 3 µM 0.270599369359816 0.385761816453613 no 1252 0.393349590457036 1775 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2050 5263056 171 µM 0.27023785862425 0.385913430548293 no 1253 0.393488634409342 1961 763468 YGL055W OLE1 SGTC_440 fluspirilene 35.1 µM 0.269664190225243 0.386154057271373 no 1254 0.39370930613735 1900 3396 An atypical antipsychotic. SGTC_2198 6589944 200 µM 0.269645301254785 0.386161981045164 no 1255 0.393716572695909 1895 5290268 SGTC_1265 0819-1001 68.8 µM 0.269149511695982 0.386369977816052 no 1256 0.393907315421971 1840 3106768 SGTC_2078 5212016 200 µM 0.268192560269161 0.386771536427295 no 1257 0.394275550673026 1966 1899708 SGTC_1098 clofazimine 15.1 µM 0.267950935953999 0.386872946681832 no 1258 0.394368542753813 1918 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1643 st009866 20.2 µM 0.266321677027085 0.387556951531119 no 1259 0.394995739954173 1927 3156273 YOR207C RET1 SGTC_1550 gossypolone 36.6 µM 0.26552418389083 0.387891887098723 no 1260 0.39530284110282 1902 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2693 st077581 40.7 µM 0.265440270721641 0.387927134269533 no 1261 0.395335158432989 1928 25238761 SGTC_396 dithiazanine 1.25 µM 0.263250498177441 0.388847259360766 no 1262 0.396178755520496 1791 10578 An antihelmenthic. SGTC_3137 9097352 49.47 µM 0.26229502909745 0.389248935707402 no 1263 0.396546997056924 1922 44120435 SGTC_1521 st012942 49.4 µM 0.261836846131856 0.389441596477774 no 1264 0.396723615333354 1998 24207259 SGTC_2053 5265679 138 µM 0.260268770742882 0.390101159891524 no 1265 0.397328230015663 1815 764595 SGTC_1082 camptothecin 424.86 nM 0.259596746311204 0.390383923612004 no 1266 0.397587423188897 1606 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1758 st042942 75.2445 µM 0.258951080451675 0.390655651222043 no 1267 0.39783649271883 1963 669317 SGTC_734 2023-0417 80 µM 0.258696024782851 0.390763005780922 no 1268 0.397934893474049 1910 3935732 SGTC_2707 st078556 66.6 µM 0.258625706189787 0.390792604790132 no 1269 0.397962023606005 1994 17250899 SGTC_1737 st035557 69.7 µM 0.258209144153211 0.390967960057057 no 1270 0.398122750574108 1773 5716916 SGTC_2903 5923464 63.88 µM 0.256737896337001 0.391587471313184 no 1271 0.398690557391153 1983 2876576 SGTC_3131 9127911 49.47 µM 0.256437396429039 0.391714039329914 no 1272 0.398806557403881 1880 45595681 SGTC_477 mead ethanolamide 10 µM 0.256139781817481 0.391839403382341 no 1273 0.398921452435456 1906 16061185 SGTC_2115 tiliquinol 12.7705 µM 0.256110241256823 0.3918518473507 no 1274 0.398932857137297 1880 71208 A bioactive hydroxyquinoline. SGTC_2915 7971052 15.16 µM 0.256057613174094 0.391874017217471 no 1275 0.398953175435051 1950 5741558 SGTC_1132 3456-3614 2.5 µM 0.255340597762815 0.392176098816313 no 1276 0.399230023198587 2008 3125502 SGTC_2912 7964298 10.93 µM 0.25510464158729 0.392275522364734 no 1277 0.399321139639833 1816 2975850 SGTC_3127 9126946 49.47 µM 0.254892782910192 0.392364798075687 no 1278 0.399402955304784 1773 27243249 SGTC_2267 7931562 200 µM 0.254255565395737 0.392633351043892 no 1279 0.399649062823931 1726 934880 SGTC_2280 7785178 200 µM 0.254229274917829 0.39264443216779 no 1280 0.399659217646063 1860 2954328 SGTC_1379 2144-0755 36.5 µM 0.253282844215264 0.393043399346158 no 1281 0.400024826156225 1981 5392327 SGTC_2697 mebhydrolin 72.4 µM 0.25307632698864 0.39313047148377 no 1282 0.40010461592973 1958 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2611 pyromycin 23.93 µM 0.252718190198533 0.393281482387964 no 1283 0.400242995159607 1788 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3287 9117173 37.0625 µM 0.251959044119667 0.393601634755241 no 1284 0.400536360367628 1960 2789709 SGTC_3103 9120822 49.47 µM 0.250549259038898 0.39419636983485 no 1285 0.401081307950399 1968 17141819 SGTC_2492 derrusnin 100 µM 0.250452346471921 0.394237262667508 no 1286 0.401118776254103 1853 1715307 Part of coumarin class of compounds. SGTC_2949 9072542 2.23 µM 0.248615685781806 0.395012472469888 no 1287 0.401829036951335 1816 16457352 SGTC_2433 5607874 27.82 µM 0.247081678966827 0.395660258232172 no 1288 0.402422506149829 1823 2252428 SGTC_1191 1487-1166 10.6 µM 0.247031233746672 0.395681565322672 no 1289 0.402442025982689 1935 3955771 SGTC_139 0099-0334 718.624 µM 0.24674419435731 0.395802811170865 no 1290 0.402553100815475 2015 97690 SGTC_2702 st077768 96.8 µM 0.24669952932671 0.395821678650463 no 1291 0.402570385425479 1838 6484119 SGTC_1367 1812-0510 76.9 µM 0.246529251672482 0.395893609870942 no 1292 0.402636281739152 1905 1142582 YDR527W RBA50 SGTC_1200 1643-0193 18.4 µM 0.243541237969825 0.397156425961611 no 1293 0.403793071631371 1982 5403974 SGTC_1074 carmofur 3.8 µM 0.243012949216552 0.397379807819914 no 1294 0.403997683037244 1897 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1173 0443-0020 122 µM 0.242963491389594 0.397400722314423 no 1295 0.404016839883429 1843 5331295 SGTC_1467 k284-1082 293 µM 0.241696096386343 0.397936772856216 no 1296 0.404507827267769 1989 3334705 SGTC_110 0850-0284 111.64 µM 0.241008093792939 0.398227847489675 no 1297 0.404774421730807 1979 3906265 SGTC_1139 k015-0024 46.9 µM 0.240171592953079 0.39858182385897 no 1298 0.405098617392425 2008 2766652 SGTC_2399 5884133 200 µM 0.238556487995434 0.399265512715415 no 1299 0.405724754278592 1834 722445 SGTC_856 0433-0016 11.3 µM 0.237868139456797 0.399556991074932 no 1300 0.405991683677931 1884 3911780 SGTC_838 0109-0203 71.4 µM 0.234836340276056 0.400841458287824 no 1301 0.407167880436129 1895 759422 SGTC_1313 1220-0047 237 µM 0.234646896128543 0.400921754896915 no 1302 0.40724140384891 1934 3528706 SGTC_1628 st004252 77.7 µM 0.234315956471435 0.401062034947174 no 1303 0.407369849613114 1979 692968 SGTC_622 1348-1566 26.3 µM 0.232499730893815 0.401832130698613 no 1304 0.408074948102485 1953 7340407 SGTC_716 1683-5115 658 µM 0.231952718704953 0.40206414357332 no 1305 0.408287368651304 2022 723597 SGTC_1622 st003707 19.4 µM 0.231411552170304 0.402293711002257 no 1306 0.408497545688165 1917 10140899 SGTC_2810 7959871 45.46 µM 0.231239960514446 0.402366508677883 no 1307 0.408564193567167 1953 2974535 SGTC_3231 9132313 49.47 µM 0.23108608203138 0.402431794428644 no 1308 0.408623963725663 1914 4905967 SGTC_2653 dihydrofissinolide 100 µM 0.230461551171527 0.402696790945871 no 1309 0.408866568558625 1934 6857746 SGTC_19 0279-0214 38.434 µM 0.230144605323708 0.402831292276702 no 1310 0.408989702490637 1920 3566274 YBR002C RER2 SGTC_2739 tacrine 100.86 µM 0.230067893653752 0.402863847900361 no 1311 0.409019506438727 1917 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1814 st052110 31.539 µM 0.229184119544218 0.403238960829782 no 1312 0.409362907446207 1999 674163 SGTC_1981 st071826 47 µM 0.228220239688922 0.403648175709615 no 1313 0.40973751379649 1897 11838600 SGTC_2824 7998404 51.95 µM 0.227931802279245 0.403770652247246 no 1314 0.409849629369305 1916 837851 SGTC_1261 0712-0010 12.7 µM 0.225125332495042 0.404962828643843 no 1315 0.410940887139409 2011 2840123 SGTC_2592 piperlongumine 83.33 µM 0.224995773306247 0.405017886231551 no 1316 0.410991281192452 1838 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_829 1635-0120 117 µM 0.224881420143141 0.405066483415207 no 1317 0.411035761846842 2006 285054 SGTC_845 0330-0138 4.51 µM 0.223906145635213 0.405481009668999 no 1318 0.41141516680363 2013 9039800 SGTC_2770 toltrazuril 17.5 µM 0.223854498812371 0.405502964360658 no 1319 0.411435260958048 2027 68591 Kills coccidiodes. SGTC_1161 k007-0610 110 µM 0.222814761014237 0.405945012543647 no 1320 0.411839839581157 2033 5843850 SGTC_1347 1493-0251 600 nM 0.221336420502343 0.40657374060502 no 1321 0.412415246835278 2001 3986378 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.221074229287357 0.406685273926708 no 1322 0.41251731793555 1805 5711223 A potent inhibitor of glutathione S-transferases. SGTC_607 4491-0986 66.8 µM 0.220382606404975 0.406979519157189 no 1323 0.412786595253423 2025 698981 YDR232W HEM1 SGTC_1357 1503-1303 39.5 µM 0.219570221868536 0.407325208490024 no 1324 0.413102942478651 1902 292895 SGTC_2755 lomerizine 42.69 µM 0.218988046943378 0.407572982467974 no 1325 0.413329679476323 1866 3949 A calcium channel blocker. SGTC_2296 7971656 126.45 µM 0.218921989695182 0.407601098808048 no 1326 0.413355408317297 1879 666570 SGTC_2627 acetyl isogambogic acid 100 µM 0.217649133391197 0.408142965000333 no 1327 0.413851249570603 1849 6857789 A caspase activator and apoptosis inducer. SGTC_2625 euphol 100 µM 0.216958866911477 0.408436891098977 no 1328 0.414120200423297 2043 6708538 A triterpene alcohol. SGTC_74 000s-0487 160.283 µM 0.216863351873103 0.408477566934707 no 1329 0.414157419444628 2054 677548 SGTC_235 0330-0087 5 mM 0.215088338306737 0.409233649496803 no 1330 0.414849222908625 1919 46494818 YHR062C RPP1 SGTC_1630 st005209 31.3 µM 0.214464869447378 0.409499301819477 no 1331 0.415092279858021 2080 3367314 SGTC_964 1287-0107 19.4 µM 0.214138262221486 0.40963848168987 no 1332 0.415219619413897 2011 51516812 YPR165W RHO1 SGTC_1199 1638-0010 4.46 µM 0.213550146149829 0.409889129217744 no 1333 0.415448940033605 1868 3111136 SGTC_1545 lovastatin 49.4 µM 0.213138083471894 0.410064766993334 no 1334 0.415609630359808 1939 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1254 0550-0035 264 µM 0.213106272954919 0.410078326672674 no 1335 0.415622035958683 1984 15121435 SGTC_2865 9030313 51.95 µM 0.213062311624823 0.410097065983619 no 1336 0.415639180321056 1845 42562754 SGTC_1508 1080-0625 72.9 µM 0.212209413068744 0.410460669978685 no 1337 0.415971831705235 2014 767111 SGTC_3065 9113888 49.47 µM 0.209133211547157 0.411772740136235 no 1338 0.417172124416083 2000 16648368 SGTC_760 0568-0725 82.9 µM 0.208868191543961 0.411885823606808 no 1339 0.417275567973426 2058 3916171 SGTC_1518 st038567 90.8 µM 0.207858650875776 0.412316659414747 no 1340 0.417669667897261 2036 77966 SGTC_612 0302-0167 22.4 µM 0.207373044995402 0.412523936293319 no 1341 0.417859266010104 2010 235821 SGTC_1951 sophoraflavanone G 9.2 µM 0.207335882375611 0.41253979985785 no 1342 0.417873776429083 1829 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_500 h-89 112 µM 0.206936124504904 0.412710453066718 no 1343 0.418029871904049 2057 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3068 9116768 49.47 µM 0.206468631785055 0.412910042630639 no 1344 0.418212432526852 1937 41904888 SGTC_719 2810-4230 27.3 µM 0.205946388727149 0.413133033718708 no 1345 0.418416394545815 1968 721079 SGTC_745 0469-0705 296 µM 0.205194379342162 0.413454181302329 no 1346 0.418710130326098 2048 3486736 SGTC_2244 6635614 200 µM 0.204286735160384 0.413841870242148 no 1347 0.419064717604657 1923 836499 SGTC_367 0335-0881 7.1 µM 0.204115059488817 0.413915208830141 no 1348 0.419131793150141 2011 23828853 SGTC_682 0kpi-0099 17 µM 0.203427234765699 0.414209072595818 no 1349 0.419400557278922 1901 1714895 YML126C ERG13 SGTC_2405 ticlatone 3.52 µM 0.201619920296019 0.414981451667502 no 1350 0.420106935445362 1818 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1044 1222-0021 1.78 µM 0.199851969332275 0.415737326358467 no 1351 0.420798177728687 1981 4306703 SGTC_2698 st077697 67.5 µM 0.199821546897023 0.415750335988753 no 1352 0.420810074587973 1878 3154499 SGTC_2643 anethole 100 µM 0.199560752063925 0.415861864193036 no 1353 0.420912062796569 1972 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1688 st021091 57.6 µM 0.199501275372208 0.415887300188538 no 1354 0.420935322901397 2074 3656366 SGTC_2140 5586273 200 µM 0.199392375918485 0.41593387339641 no 1355 0.42097791194219 2036 854421 SGTC_488 nitrendipine 139 µM 0.19914882658514 0.416038036810996 no 1356 0.42107316399839 2018 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1810 st050138 53 µM 0.198274187629048 0.416412159003714 no 1357 0.421415273027302 2064 3444541 SGTC_2793 7325131 81.82 µM 0.198135345245897 0.416471555073998 no 1358 0.421469585736615 1959 4176441 SGTC_1746 st038117 42 µM 0.198008303163933 0.416525904706085 no 1359 0.421519283683794 1917 2898218 SGTC_2560 caryophyllene 100 µM 0.197553300765755 0.416720571504736 no 1360 0.421697287595397 2013 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_5 0352-0601 109.883 µM 0.196393669016771 0.417216796964954 no 1361 0.422151025583166 1982 762456 SGTC_1281 0884-0031 11.8 µM 0.196255046784578 0.417276124534479 no 1362 0.422205272291711 1918 1548255 SGTC_1446 4239-0190 62 µM 0.195649518427968 0.41753530074248 no 1363 0.422442249554088 1907 1340085 SGTC_2964 9083345 53.42 µM 0.193823165527613 0.418317226719478 no 1364 0.423157173750652 1915 17741579 SGTC_448 monastrol 171 µM 0.193737174181727 0.41835405062623 no 1365 0.423190841242942 2042 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3119 9125183 49.47 µM 0.192348699939674 0.418948733092256 no 1366 0.423734536748298 2070 22695334 SGTC_2360 9040895 200 µM 0.192112488409126 0.419049920786468 no 1367 0.423827046390892 1932 4914414 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.191530065172286 0.419299440636357 no 1368 0.424055163959211 1958 229346 A bile salt which induces apoptosis. SGTC_3208 9114115 49.47 µM 0.19151676027435 0.419305141056605 no 1369 0.424060375382962 1841 650895 SGTC_1934 st074720 32.6 µM 0.190732647727933 0.419641120221124 no 1370 0.424367529514899 1933 17250992 SGTC_1015 4130-4525 82 µM 0.190509360284827 0.419736805898922 no 1371 0.424455004529501 1890 1363237 SGTC_452 diindolylmethane 8 µM 0.190375149658401 0.41979432164865 no 1372 0.424507584630741 2021 3071 Inhibits expression of several cancer promoting factors. SGTC_807 1315-0151 48 µM 0.188756731635221 0.420488026659694 no 1373 0.425141742647304 2104 4011080 SGTC_1119 parthenolide 318.541 nM 0.188303213131322 0.420682463397462 no 1374 0.425319483348689 2010 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_505 gw-5074 63.9 µM 0.187155809718007 0.421174475342503 no 1375 0.4257692356529 2046 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1436 4092-1007 8.32 µM 0.18500669927301 0.422096354643803 no 1376 0.426611890511168 2000 2881121 SGTC_2532 xanthone 78.9 µM 0.184916176253304 0.422135194674033 no 1377 0.426647391490378 2051 7020 An insecticide. SGTC_312 4092-0653 6.84 µM 0.184337959975076 0.422383303428753 no 1378 0.426874168196224 2050 1148278 SGTC_1610 st001799 48.1 µM 0.183246712328177 0.422851634368371 no 1379 0.427302221854812 1910 621897 SGTC_320 4092-0846 5.34 µM 0.182627291267981 0.423117519975161 no 1380 0.427545234564679 2052 1359356 SGTC_374 0880-0231 82.3 µM 0.182124692310355 0.423333285603342 no 1381 0.427742435563382 2051 6833587 SGTC_2673 kobusone 100 µM 0.181000425909712 0.423816016087892 no 1382 0.428183620854315 2032 6710676 An epoxy ketone and protein crosslinker. SGTC_362 0310-0100 9.03 µM 0.180623559508367 0.423977858254658 no 1383 0.428331531112209 1973 790235 SGTC_2452 5863136 48.41 µM 0.18057339154568 0.42399940343998 no 1384 0.428351221492207 2021 2184096 SGTC_1439 4092-1168 46 µM 0.179814714242165 0.424325253439222 no 1385 0.428649015804854 2058 2886240 SGTC_2459 5811157 9.22 µM 0.179683155110441 0.424381763025735 no 1386 0.428700659238089 2114 2870684 YBR192W RIM2 SGTC_2906 7926292 26.41 µM 0.176387156384473 0.425798022584848 no 1387 0.429994897096605 1988 2966319 SGTC_1871 st057448 67.3 µM 0.175565817124721 0.426151094098442 no 1388 0.430317529572281 2068 691747 SGTC_2257 7960413 200 µM 0.173489009387434 0.427044121011228 no 1389 0.431133533065328 2043 2974689 YIL048W NEO1 SGTC_2297 7971671 152.32 µM 0.173180802955092 0.427176681698754 no 1390 0.431254656332192 2066 909016 SGTC_659 k018-0002 107 µM 0.1730908873438 0.427215356274532 no 1391 0.431289993843188 2119 6797879 YHR007C ERG11 SGTC_1679 SEC14.276 6.7 µM 0.172854248893862 0.427317142739098 no 1392 0.431382997160126 2112 1005053 YMR079W SEC14 SGTC_2996 9066192 71.4286 µM 0.172837403836556 0.427324388571305 no 1393 0.431389617726397 1934 6472854 SGTC_574 1315-0397 40 µM 0.171988202463059 0.427689700774152 no 1394 0.431723401933457 2076 6794277 SGTC_3016 9080866 49.47 µM 0.170351742675923 0.428393852949366 no 1395 0.432366760554568 2044 17066299 SGTC_2925 9010536 32.5 µM 0.169635676414136 0.428702040909619 no 1396 0.432648331719697 2025 2994177 SGTC_813 k007-0158 173 µM 0.169488895686728 0.428765219284083 no 1397 0.432706052982074 2071 6523916 SGTC_6 0844-0013 19.835 µM 0.166975908850228 0.429847158261758 no 1398 0.433694502369485 2110 1584900 SGTC_341 1486-1430 230 µM 0.16664001998312 0.429991811645331 no 1399 0.433826651275985 2004 2054753 YPL210C SRP72 SGTC_2518 prenyletin 46.28 µM 0.16617739140587 0.430191061939463 no 1400 0.434008675550136 2102 3873459 A coumarin with calcium channel inhibitory activity. SGTC_82 0054-0107 293.755 µM 0.165893966424407 0.430313139515226 no 1401 0.434120197899407 2112 3104697 SGTC_782 0083-0095 30.5 µM 0.165868362530611 0.430324168021943 no 1402 0.434130272803895 2150 3591729 An indicator and reagent. SGTC_1433 4060-0023 7.6 µM 0.164576659822024 0.430880620628088 no 1403 0.434638601722806 2077 3840627 SGTC_621 3584-0052 32.1 µM 0.164465639304123 0.430928453577349 no 1404 0.434682297125373 2120 2273927 SGTC_1294 1000-1494 117 µM 0.164438132982117 0.430940304773148 no 1405 0.434693123173834 1960 712797 YDL207W GLE1 SGTC_1968 st069590 43.6 µM 0.163259427978962 0.431448212270192 no 1406 0.43515708851742 2105 6384066 SGTC_945 3381-0768 11.3 µM 0.162866592239378 0.431617511589075 no 1407 0.435311737550525 2115 1126236 YIL048W NEO1 SGTC_277 nystatin 15.5 µM 0.162822420275298 0.431636549042999 no 1408 0.435329127502925 2069 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2628 lathosterol 100 µM 0.162783735074478 0.431653221914686 no 1409 0.435344357487663 2020 6710616 SGTC_927 2425-1185 123 µM 0.161640731152379 0.432145898133592 no 1410 0.435794390123718 1955 730375 SGTC_2277 7947813 106.88 µM 0.160136326302192 0.432794512036525 no 1411 0.436386843077045 2114 1246798 SGTC_2983 9022671 12.99 µM 0.156417049571907 0.434398826650701 no 1412 0.437852149483737 2170 6405161 SGTC_1350 1495-0454 146 µM 0.15631580746567 0.434442512790652 no 1413 0.437892048472379 2102 1069057 SGTC_2076 5212012 200 µM 0.15618583398061 0.434498597742606 no 1414 0.437943271273904 2114 604802 SGTC_1437 4092-1038 11.6 µM 0.155848753590975 0.434644057683869 no 1415 0.438076120149839 2043 3977136 SGTC_136 0097-0015 404.482 µM 0.153678656286458 0.435580728449128 no 1416 0.438931557329426 2163 4861337 SGTC_1239 0337-0584 35.4 µM 0.151615400117669 0.436471619137224 no 1417 0.439745143148109 2135 914301 YML130C ERO1 SGTC_2753 fluvastatin 17.09 µM 0.150644494940395 0.436890956828826 no 1418 0.440128080003327 2060 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2419 paclitaxel 166.5 µM 0.150296536817268 0.437041258571785 no 1419 0.440265332587781 1990 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2665 lovastatin 100 µM 0.149975271376738 0.437180038385312 no 1420 0.440392062578607 2050 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2261 9010538 184.68 µM 0.149361494558974 0.437445198348416 no 1421 0.440634196874056 1984 6457250 SGTC_717 1532-0246 73.2 µM 0.14835581047477 0.437879728283792 no 1422 0.441030986109295 2030 9561992 SGTC_2666 tannic acid 100 µM 0.147704247176561 0.438161291864186 no 1423 0.441288089821846 2107 16134267 A thiamine antagonist. SGTC_83 0170-0301 39.027 µM 0.14743413461008 0.438278026259692 no 1424 0.44139468218999 2154 3089716 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.147235301055893 0.438363959476956 no 1425 0.441473149002848 2129 140250 A respiratory chain inhibitor. SGTC_732 3970-1727 52.7 µM 0.146966128781778 0.438480296782656 no 1426 0.441579377642871 2152 1275699 SGTC_457 grayanotoxin iii 135 µM 0.146696107723287 0.438597006277485 no 1427 0.441685945477317 2075 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1842 st055362 61.2 µM 0.146566690424467 0.438652945391799 no 1428 0.441737023439743 2041 676032 SGTC_884 0851-0618 334 µM 0.145700418218222 0.439027412926636 no 1429 0.442078945601322 2142 9642473 SGTC_174 3553-0389 74.3 µM 0.145002338657865 0.439329214767846 no 1430 0.44235451266241 2089 738071 SGTC_1961 st076550 68.7 µM 0.143365040409969 0.440037208577795 no 1431 0.443000945716645 2069 1579337 SGTC_1364 1653-0028 37.6 µM 0.143047010539144 0.440174752067709 no 1432 0.443126526945564 2065 5718652 SGTC_2546 rhodinyl acetate 100 µM 0.142275615072424 0.440508399825484 no 1433 0.443431153460937 2170 6708682 SGTC_2045 5106652 78.05 µM 0.141940079602493 0.440653540472778 no 1434 0.443563667926759 2134 673349 SGTC_2162 5663267 200 µM 0.139671073408861 0.441635239717184 no 1435 0.444459941206153 2148 6456493 SGTC_1880 MG-132 525 µM 0.139077899725009 0.441891939275783 no 1436 0.444694295975352 2159 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.138728082325916 0.442043336353336 no 1437 0.444832513089921 2098 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1056 3448-1962 115 µM 0.138421467127457 0.442176042962448 no 1438 0.444953666005767 2068 715507 SGTC_1262 0737-0114 49.6 µM 0.13664315951897 0.442945842595162 no 1439 0.445656430038692 2185 765919 SGTC_2265 7929201 200 µM 0.135930667594008 0.443254329045928 no 1440 0.445938045622597 2181 1265108 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.135736267121249 0.443338504277968 no 1441 0.44601488801127 2037 75037 A free radical scavenger. SGTC_1988 st071872 53.4 µM 0.135493958279941 0.443443427370458 no 1442 0.446110670401618 2179 16414116 SGTC_2432 5630864 12.22 µM 0.134857476824747 0.44371905154644 no 1443 0.446362280458288 2073 5714970 SGTC_774 k060-0086 136 µM 0.133975341594485 0.444101099491676 no 1444 0.446711036590356 2183 5911235 SGTC_2467 5474540 200 µM 0.132932388680398 0.444552863690359 no 1445 0.447123425873195 2157 5413519 SGTC_2178 5812956 200 µM 0.13243782165462 0.444767114949698 no 1446 0.447319000391113 2191 5403383 SGTC_1522 st012842 45.6 µM 0.131548652497033 0.445152352248004 no 1447 0.447670650904617 1993 3491067 YOR116C RPO31 SGTC_214 4373-3496 70 µM 0.131002898247702 0.445388828877306 no 1448 0.447886507347754 2122 3779166 SGTC_2679 rapamycin 1 nM 0.130606599752068 0.445560558152508 no 1449 0.448043260803162 2092 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_443 clozapine 122 µM 0.129315449800091 0.446120126915271 no 1450 0.448554023452928 2202 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_24 0417-1663 219 µM 0.12907964023869 0.446222335548462 no 1451 0.448647315978955 2060 4329390 SGTC_3053 9095903 49.47 µM 0.128917533382953 0.446292600761115 no 1452 0.448711451404323 2194 17174018 SGTC_833 3852-0053 558 µM 0.128840390505618 0.446326038931782 no 1453 0.448741972430392 2121 3123681 SGTC_3216 9129716 49.47 µM 0.128436583273438 0.446501078490203 no 1454 0.448901740811122 2096 8056934 SGTC_2394 5221648 200 µM 0.128418887451155 0.446508749391189 no 1455 0.448908742442722 2113 788586 SGTC_1180 1193-0155 285 µM 0.127560986282994 0.446880661964999 no 1456 0.449248203633943 2075 2921347 SGTC_258 haloperidol 50.781 µM 0.12616370728981 0.447486502508883 no 1457 0.449801169573414 2013 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_96 0929-0093 37.281 µM 0.125426143693257 0.447806349228637 no 1458 0.450093095933787 2042 6991579 SGTC_1192 1488-0095 21.4 µM 0.124958509919764 0.448009157645347 no 1459 0.450278198549862 2075 915875 SGTC_1459 k035-0031 35.7 µM 0.123750324188492 0.448533199345398 no 1460 0.450756482461765 2039 3877128 YMR208W ERG12 SGTC_2318 6029776 164 µM 0.123685649397064 0.448561254102552 no 1461 0.450782087263447 2121 818325 SGTC_879 0831-1030 162 µM 0.122914564666834 0.448895756517387 no 1462 0.451087376073956 2127 1549252 SGTC_3168 9103419 49.47 µM 0.122419265912096 0.449110640058064 no 1463 0.451283490637453 2197 16649256 SGTC_376 3970-0862 59.1 µM 0.121930191683675 0.449322837758187 no 1464 0.451477152255476 2192 3135186 SGTC_1022 4477-0945 21.3 µM 0.121317274925781 0.449588788249845 no 1465 0.451719868833539 2057 4648966 SGTC_1150 3909-7983 10.9 µM 0.118366171933638 0.450869615209101 no 1466 0.452888764099825 2053 23965914 SGTC_3126 9127922 49.47 µM 0.118045540676499 0.451008805478015 no 1467 0.45301578693585 2125 45595682 SGTC_1499 4480-0877 67.3 µM 0.118006267927843 0.45102585471206 no 1468 0.453031345749459 2200 2861909 SGTC_354 2783-3500 4.88 µM 0.116566659828377 0.451650884924805 no 1469 0.453601729583187 2046 6740761 SGTC_1445 4239-0156 97.7 µM 0.115847135581427 0.451963323575548 no 1470 0.453886846590919 2191 4008346 SGTC_2105 5350118 200 µM 0.11470906115105 0.452457569734876 no 1471 0.45433786579092 2090 2133313 SGTC_1085 doxorubicin 7.67 µM 0.11456496696332 0.45252015263398 no 1472 0.454394974567521 2209 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2738 aclarubicin 5.55 µM 0.114243398161494 0.452659820449725 no 1473 0.454522425166102 2165 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_236 1509-0011 5.31 µM 0.113964743075931 0.452780854177026 no 1474 0.454632871126891 2178 3107280 SGTC_2379 9035213 200 µM 0.113292783818316 0.453072737442024 no 1475 0.454899219043258 2240 646551 SGTC_3204 9114183 49.47 µM 0.11287578281971 0.453253885608253 no 1476 0.455064518058698 2111 17027248 SGTC_1197 1601-0112 267 µM 0.110838887932589 0.454138866183154 no 1477 0.45587205360752 2120 7350313 SGTC_2927 9011802 47.9 µM 0.110559079008369 0.45426045414668 no 1478 0.455982999351387 2080 43912568 SGTC_626 0214-0009 33 µM 0.110068771034943 0.454473522541179 no 1479 0.456177417372074 2170 3437874 SGTC_2364 9055074 200 µM 0.110014172295429 0.454497249799174 no 1480 0.456199067637205 2103 6470630 SGTC_2243 6634756 200 µM 0.109724940203442 0.454622945598885 no 1481 0.456313760208532 2209 885676 SGTC_66 0109-0187 42.4 µM 0.109488880887727 0.454725536699598 no 1482 0.456407370257482 2237 759417 SGTC_1900 st060200 72.8 µM 0.108694345041402 0.4550708631928 no 1483 0.456722463642054 2105 688945 SGTC_2526 patulin 37.61 µM 0.107788108684073 0.455464779146071 no 1484 0.457081887912834 2145 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_259 usnic acid 108.925 µM 0.107758986185288 0.455477438621436 no 1485 0.457093438830987 2186 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.1071507734636 0.455741837440052 no 1486 0.4573346837956 2143 6708514 SGTC_706 4262-0057 46.9 µM 0.107101941169077 0.455763066392513 no 1487 0.457354053598571 2196 883298 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.106914165879358 0.455844699462734 no 1488 0.457428537430747 2215 97141 SGTC_1510 1123-0200 71.5 µM 0.106228577612049 0.456142766596499 no 1489 0.45770049878409 2205 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1072 oxiconazole 14.9 nM 0.106041923408087 0.456223920872004 no 1490 0.457774544808252 2228 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_794 k038-0031 316 µM 0.10505575942592 0.456652719500263 no 1491 0.458165781919592 2215 6624242 SGTC_1212 0520-0165 585 µM 0.103875402856136 0.457166022254847 no 1492 0.458634113584282 2238 5403258 SGTC_2993 9054257 71.4286 µM 0.103772948994436 0.457210579843778 no 1493 0.458674767058708 2211 6470217 YGL055W OLE1 SGTC_3298 9116858 71.43 µM 0.102846367941255 0.457613577964795 no 1494 0.459042452029434 2180 2506942 SGTC_3098 9119039 49.47 µM 0.102378009372545 0.457817297879405 no 1495 0.459228318962143 2248 17161528 SGTC_1336 1486-0901 104 µM 0.102022267086912 0.457972040981974 no 1496 0.459369500360879 2147 5006114 SGTC_3116 9124943 49.47 µM 0.101753421384529 0.458088989469026 no 1497 0.459476199011885 2056 41905195 YPL160W CDC60 SGTC_2221 6807166 181.081 µM 0.101730064995757 0.458099149722283 no 1498 0.459485468761152 2215 674925 SGTC_315 k915-0449 187 µM 0.101601654233164 0.458155010125191 no 1499 0.459536433179061 2138 20970215 YNL149C PGA2 SGTC_2061 5245884 80.95 µM 0.101422927843568 0.45823275987572 no 1500 0.459607368265231 2199 573863 SGTC_2844 9010103 25.97 µM 0.101016252464497 0.458409678196897 no 1501 0.459768779285062 2116 2480525 SGTC_1306 1185-0270 9.02 µM 0.100575327255827 0.45860150572615 no 1502 0.459943791685203 2201 1548076 SGTC_2766 oltipraz 83.91 µM 0.0974026132563567 0.459982098244723 no 1503 0.461203334760097 2218 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_288 1315-0019 35.1 µM 0.0970944427845618 0.460116223250566 no 1504 0.461325697013403 2172 6811474 SGTC_2164 5685496 200 µM 0.09665080658112 0.460309314959885 no 1505 0.461501853754111 2232 759046 SGTC_520 3584-0023 682 µM 0.096530964326105 0.46036147765293 no 1506 0.46154944138647 2066 1340790 SGTC_1179 1021-1431 9.29 µM 0.0963758264425331 0.460429004179346 no 1507 0.461611045221771 2165 2840958 SGTC_1447 4239-0816 81.9 µM 0.0961414395457336 0.460531027413936 no 1508 0.461704119862285 2075 1341554 SGTC_2843 9000894 45.46 µM 0.0954807005845986 0.460818645877563 no 1509 0.461966509460406 2256 2242070 SGTC_815 1582-0027 36.9 µM 0.0936718932229781 0.461606120845545 no 1510 0.462684899020392 2179 3128206 SGTC_1423 4048-0112 5.59 µM 0.0934468420629347 0.461704108791055 no 1511 0.462774289353129 2247 X1423 SGTC_1816 st051957 91.6 µM 0.0925048045054907 0.462114299913248 no 1512 0.463148487073555 2203 674121 SGTC_476 mead acid 10 µM 0.0915530744948048 0.462528752338426 no 1513 0.463526567960316 2230 5312531 An omega 9 fatty acid. SGTC_1878 temozolomide 1 mM 0.0914428305603197 0.462576763198651 no 1514 0.463570365210115 2258 5394 DNA alkylating agent. SGTC_2981 9013952 38.96 µM 0.0909235951868037 0.46280289576538 no 1515 0.463776650798563 2019 2996344 SGTC_2780 5215298 71.43 µM 0.0906465820833207 0.462923542861268 no 1516 0.463886708557312 2271 2834131 SGTC_985 1493-0307 8.71 µM 0.0899822731178412 0.463212882210901 no 1517 0.464150650839549 2258 3278274 SGTC_2649 anisomycin 9.56 µM 0.0899699913340143 0.463218231717779 no 1518 0.464155530769129 2177 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1812 st052057 4.327 µM 0.0885027819294461 0.4638573433765 no 1519 0.464738536678721 2228 3645418 SGTC_3325 9138760 55.175 µM 0.0883700986435915 0.46391514440938 no 1520 0.464791263061017 2144 43844959 SGTC_553 k007-0256 45.7 µM 0.0880998128787322 0.464032891785928 no 1521 0.464898672551909 2157 6287000 SGTC_965 1291-5240 308 µM 0.0870025872723788 0.464510919743158 no 1522 0.465334727780932 2225 2834598 SGTC_2960 9079389 5.97 µM 0.0869646212732688 0.464527461299773 no 1523 0.465349816832091 2260 16457355 SGTC_1776 st049249 45.9 µM 0.0869523588585143 0.464532803972955 no 1524 0.465354690366623 2136 1822314 SGTC_1621 st003705 32.4 µM 0.086561690319805 0.464703019656193 no 1525 0.465509959125431 2248 24207032 SGTC_772 k072-0172 35.3 µM 0.0863575835029802 0.464791952299192 no 1526 0.465591082188541 2061 5861980 SGTC_417 st075190 100 µM 0.0858577210768021 0.465009757866176 no 1527 0.465789760522666 2252 222757 SGTC_1075 aripiprazole 15.2 µM 0.0854724637842591 0.46517763357813 no 1528 0.465942893030374 2220 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1732 st034308 51.822 µM 0.0845795962780911 0.465566724015546 no 1529 0.466297810371847 2072 830119 SGTC_947 3447-0010 211 µM 0.0845211326653636 0.465592202220768 no 1530 0.466321050760159 2256 748350 SGTC_1155 4088-0394 48.2 µM 0.0842778087010577 0.465698243331024 no 1531 0.466417777856243 2168 2326248 SGTC_1166 k206-0078 225 µM 0.0831763895248653 0.466178274545958 no 1532 0.466855643051868 2243 5404595 SGTC_702 1488-0190 94 µM 0.0830911924486361 0.466215408023463 no 1533 0.466889514518564 2262 949357 SGTC_1400 3771-8998 51.5 µM 0.082813914418371 0.466336262767479 no 1534 0.466999752513918 2217 670767 SGTC_596 1155-0152 116 µM 0.0824350888801101 0.466501383148917 no 1535 0.467150367050418 2242 280313 SGTC_526 4469-0568 170 µM 0.0823541923486067 0.46653664462994 no 1536 0.467182530734013 2240 2901964 SGTC_2398 5228213 48.84 µM 0.0823489647230974 0.466538923275828 no 1537 0.467184609195057 2268 80771 YMR134W ERG29 SGTC_1487 3970-0795 2.82 µM 0.0822861755190662 0.466566292261841 no 1538 0.467209573737699 2193 3765103 SGTC_1912 st060209 90.8 µM 0.0817567620169435 0.466797062899361 no 1539 0.467420069914095 2163 688787 SGTC_161 4065-0411 162.148 µM 0.081000591679204 0.467126695876597 no 1540 0.467720740980293 2188 1906281 YLR208W SEC13 SGTC_1041 0206-0046 107 µM 0.0809748335365317 0.467137924873651 no 1541 0.467730983347438 2158 50494 SGTC_84 0443-0269 128.823 µM 0.080867952362553 0.467184518900152 no 1542 0.46777348338774 2264 6150058 SGTC_1374 2889-5571 141 µM 0.0804496029308342 0.467366899438871 no 1543 0.467939838641528 2181 2853281 SGTC_231 b-estradiol 524 µM 0.0800524332329584 0.467540052956823 no 1544 0.46809777702631 2218 450 A steroid. SGTC_601 0986-0029 62.9 µM 0.0792912822189969 0.467871908037471 no 1545 0.468400470126032 2214 24747981 SGTC_3230 9131665 49.47 µM 0.0789654078325184 0.468013993214946 no 1546 0.468530068832701 2220 15943720 SGTC_3187 9109394 49.47 µM 0.078818008458887 0.468078262465738 no 1547 0.468588689964671 2183 17098090 SGTC_1744 st037937 38.9 µM 0.0786980405790989 0.468130571618094 no 1548 0.468636402019679 2223 1016152 SGTC_1879 gemcitabine 100 µM 0.0781720432734425 0.468359926767469 no 1549 0.468845600092045 2238 60750 A nucleoside analog which inhibits DNA replication. SGTC_1613 st002381 52.1 µM 0.0781683990590676 0.468361515822466 no 1550 0.468847049488138 2292 551167 SGTC_2103 5378138 10 µM 0.0774849211575464 0.468659554368653 no 1551 0.469118893190435 2262 244142 SGTC_2113 5491891 107.031 µM 0.0765638514564224 0.469061225357153 no 1552 0.469485258433194 2213 789979 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0762483206762074 0.469198833020861 no 1553 0.46961077010479 2219 2724278 An inhibitor of dopamine biosynthesis. SGTC_2641 levomentholum 100 µM 0.076090488180715 0.46926766749994 no 1554 0.469673553767533 2254 16666 SGTC_3260 9137109 49.47 µM 0.0755931589855542 0.469484570505965 no 1555 0.469871389615622 2267 17478346 SGTC_1611 st001856 99.4 µM 0.0741885646515114 0.470097212905524 no 1556 0.470430172431074 2156 647478 SGTC_3280 9140961 49.47 µM 0.0737453075675293 0.470290563265787 no 1557 0.470606523343669 2163 4901226 SGTC_2851 9015922 71.43 µM 0.072668477398404 0.470760309610027 no 1558 0.471034966799127 2254 2996893 SGTC_1656 st012921 11 µM 0.0710633988874659 0.471460569408718 no 1559 0.47167364897565 2266 6732821 SGTC_2946 9065502 71.43 µM 0.070645230056147 0.471643021679435 no 1560 0.471840055967572 2296 16489101 SGTC_2586 curcumin 80 µM 0.068116650494606 0.472746397871137 no 1561 0.472846387981731 2262 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2307 7538926 6.34 µM 0.0676721170068862 0.472940397278446 no 1562 0.473023322909454 2200 96582 SGTC_1619 st003326 88.7 µM 0.0673703153172886 0.4730721105868 no 1563 0.47314345021385 2297 2849032 SGTC_2067 5224629 34.075 µM 0.0665362719171379 0.473436121879655 no 1564 0.473475440432217 2198 2835000 SGTC_2369 9071472 200 µM 0.0664950718685943 0.47345410387501 no 1565 0.473491840553564 2245 17296037 SGTC_3105 9121040 49.47 µM 0.0643836615255818 0.474375712519226 no 1566 0.474332369623455 2295 41448907 SGTC_3344 9148862 3.898 µM 0.0643826874856704 0.474376137709539 no 1567 0.474332757404611 2265 4905352 SGTC_2020 4017018 200 µM 0.0640178132274748 0.474535415572918 no 1568 0.474478021498264 2239 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2354 9060492 162 µM 0.0636590357178963 0.47469203600319 no 1569 0.474620861657158 2263 6471895 SGTC_1568 digitonin 820 nM 0.0636585250547769 0.474692258930428 no 1570 0.474621064969893 2301 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_294 k038-0071 157 µM 0.0634738690679882 0.474772870027491 no 1571 0.474694583368628 2230 24152826 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0631181582664061 0.474928157572954 no 1572 0.474836207461541 2299 5024745 SGTC_3209 9113616 49.47 µM 0.0629746816711385 0.474990794164635 no 1573 0.474893332696548 2312 16649353 SGTC_2648 atorvastatin 78.68 µM 0.06286299321801 0.475039553653403 no 1574 0.474937801833771 2293 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1874 staurosporine 7.6 µM 0.0622093222307228 0.475324932284041 no 1575 0.475198069402119 2272 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1366 1683-0113 21.9 µM 0.0618194897516601 0.475495130757563 no 1576 0.47535329129702 2280 708623 SGTC_1650 st011916 45.8 µM 0.0615988367142789 0.475591468506419 no 1577 0.475441151676316 2291 242528 SGTC_952 1185-0122 232 µM 0.0602722871659014 0.476170673721827 no 1578 0.475969386722558 2298 678600 SGTC_2044 5102272 200 µM 0.0602580365524831 0.47617689617704 no 1579 0.475975061580181 2243 592666 SGTC_1159 4092-0538 61.2 µM 0.0590040386960039 0.476724470305268 no 1580 0.476474445652163 2318 717301 SGTC_853 0419-0306 21 µM 0.0573130397191548 0.477462935943366 no 1581 0.477147916616994 2192 762713 SGTC_484 loperamide 105 µM 0.0567314317479274 0.477716944355723 no 1582 0.477379567706912 2302 3955 An opioid-receptor agonist. SGTC_3212 9128307 49.47 µM 0.0562432210337358 0.477930169933276 no 1583 0.477574025113908 2083 27243542 SGTC_1695 st026914 34.495 µM 0.0560703528015767 0.478005671491356 no 1584 0.477642880903644 2271 3289191 SGTC_1966 st070145 16.1 µM 0.0556101090730184 0.478206690395732 no 1585 0.47782620554656 2298 3748532 SGTC_1247 0448-0043 5.84 µM 0.0551024542877023 0.478428423275693 no 1586 0.47802842043927 2243 3089013 YGL099W LSG1 SGTC_846 0335-0850 148 µM 0.054596479917904 0.478649428829648 no 1587 0.478229971598188 2306 6819598 SGTC_3096 9117468 49.47 µM 0.0545675829406998 0.478662050996766 no 1588 0.478241482664519 2310 41316311 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0544627152825204 0.478707857251484 no 1589 0.478283256686912 2269 521171 SGTC_3219 9131112 49.47 µM 0.0537424375709736 0.479022482546902 no 1590 0.478570185672733 2321 17612988 YMR079W SEC14 SGTC_2644 guaiazulene 100 µM 0.0533378041901122 0.479199236643782 no 1591 0.478731379834553 2289 3515 A coloring agent. SGTC_1827 berberine 7.24 µM 0.0527635364552662 0.479450098332008 no 1592 0.478960157351793 2294 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_405 ebelactone b 50 µM 0.052511649510134 0.479560134572478 no 1593 0.479060506587855 2196 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_981 1488-1094 54.9 µM 0.0519798162008359 0.47979246985349 no 1594 0.479272388003626 2313 3449522 SGTC_1715 st032160 10.2275 µM 0.0511443981574507 0.480157442184245 no 1595 0.479605228825289 2295 5289825 SGTC_684 1140-0066 328 µM 0.0503513854612117 0.480503904121052 no 1596 0.479921187995894 2246 6813534 SGTC_1417 3966-0327 90.4 µM 0.0498064536577365 0.480741989730473 no 1597 0.480138311896462 2288 651118 SGTC_1957 st077035 62.4 µM 0.0494643972092115 0.480891440786289 no 1598 0.480274604681355 2337 705593 SGTC_2703 st077852 53.4 µM 0.0490597776533907 0.481068230335617 no 1599 0.48043582878426 2259 6281836 SGTC_2893 9048488 25.97 µM 0.0488620746577841 0.481154613635126 no 1600 0.480514606389686 2274 6467338 SGTC_316 k060-0003 58.6 µM 0.048799909132574 0.481181776093431 no 1601 0.480539377295771 2296 6152314 SGTC_78 0336-0123 156.75 µM 0.0484337057334761 0.48134178591395 no 1602 0.480685298762594 2177 6765896 SGTC_690 glyoxal 20.3 µM 0.0470231588450786 0.481958141625747 no 1603 0.481247384926524 2290 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_433 pimozide 108 µM 0.0465828411261112 0.482150552739062 no 1604 0.481422853990412 2333 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3332 9141069 11.198 µM 0.04650049448447 0.48218653723868 no 1605 0.481455669986343 2318 17332883 SGTC_1572 epiandrosterone 68.9 µM 0.0464249133537077 0.482219565418524 no 1606 0.481485789966197 2273 441302 A steroid. SGTC_117 lucigenin 22.078 µM 0.0452785087955124 0.482720547297802 no 1607 0.481942658681716 2213 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1103 duloxetine 36.1 µM 0.0447482555427375 0.482952278673905 no 1608 0.482153984917515 2298 60835 A selective serotonin reuptake inhibitor. SGTC_48 0382-0018 55 µM 0.0443504504678667 0.483126131307684 no 1609 0.482312528775484 2337 762596 SGTC_1750 st081859 2.357 µM 0.0439427245091168 0.483304322991495 no 1610 0.48247502947042 2304 5291695 SGTC_2036 5160441 105 µM 0.0439407337464757 0.483305193038366 no 1611 0.482475822903428 2287 134534 YIL048W NEO1 SGTC_897 1000-0139 31.4 µM 0.0436968464645076 0.48341178262213 no 1612 0.482573026487169 2323 6151020 SGTC_2075 5212009 200 µM 0.0430314443022065 0.483702598953605 no 1613 0.482838234066355 2321 780898 SGTC_2588 indole-3-carbinol 100 µM 0.0424530971052066 0.48395537465787 no 1614 0.4830687505511 2326 3712 Induces cell cycle arrest. SGTC_2718 lomofungin 53.02 µM 0.0422167587480512 0.484058671901677 no 1615 0.483162951460589 2308 5351222 A RNA synthesis inhibitor. SGTC_355 1311-2252 105 µM 0.0416248166112034 0.484317398830959 no 1616 0.483398894794181 2277 5338538 SGTC_1 0258-0098 57.368 µM 0.0412222423230123 0.484493360364751 no 1617 0.483559360965928 2237 6790032 YDR047W HEM12 SGTC_2825 7998094 58.44 µM 0.0402848305441903 0.48490310611056 no 1618 0.483933023717074 2297 2987815 SGTC_2932 9016711 44.54 µM 0.0398002683912816 0.48511491608522 no 1619 0.484126181128519 2330 7117328 SGTC_257 daunorubicin 18.5 µM 0.039264153685057 0.485349265408315 no 1620 0.484339892890246 2324 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2450 5739737 12.93 µM 0.0383770630129712 0.485737046294618 no 1621 0.48469352428562 2287 2262825 SGTC_976 1348-1067 47.6 µM 0.0379043758867568 0.485943681248192 no 1622 0.484881962052483 2352 5310671 YGL099W LSG1 SGTC_1706 st031321 9.9705 µM 0.0378474926245552 0.485968547994869 no 1623 0.484904638919022 2334 6103185 SGTC_50 0929-0078 56.389 µM 0.0377835597320236 0.485996496580893 no 1624 0.48493012622284 2273 1377751 SGTC_126 0417-1624 672.48 µM 0.0371821506891052 0.486259408921615 no 1625 0.485169885228655 2337 41912 YDL195W SEC31 SGTC_2687 chenodiol 100 µM 0.036839748571325 0.486409096313874 no 1626 0.485306390384555 2299 5702181 A cholesterol synthesis inhibitor. SGTC_348 k064-0012 10.7 µM 0.0359626205120977 0.486792557685747 no 1627 0.485656082085905 2338 5066323 SGTC_2300 7976697 71.57 µM 0.035945611064955 0.486799993969129 no 1628 0.485662863488965 2304 2236109 SGTC_854 0422-0053 192 µM 0.035208888308058 0.487122082833687 no 1629 0.485956587391005 2327 3596728 SGTC_3302 9125395 16.351 µM 0.0331507232134522 0.488021938792471 no 1630 0.486777196840272 2282 17599668 SGTC_1767 st044992 70.3 µM 0.0329931141257549 0.488090850062196 no 1631 0.486840039392588 2323 9600693 SGTC_2086 5274770 176.623 µM 0.0325626243121549 0.48827907451488 no 1632 0.487011687745893 2321 689278 SGTC_1847 st056231 15 µM 0.032384445052105 0.488356981174973 no 1633 0.487082733516282 2331 5393180 SGTC_343 4130-2827 29.8 µM 0.0323227308773198 0.488383965032244 no 1634 0.487107341027515 2311 1118244 SGTC_1684 st024538 14.6195 µM 0.031993887055183 0.488527749340069 no 1635 0.487238462913395 2335 6732859 SGTC_2595 hexamethylquercetagetin 100 µM 0.0319516599670228 0.488546212902062 no 1636 0.48725530047587 2315 386331 SGTC_65 0798-0905 34.986 µM 0.0307109459895198 0.489088719052484 no 1637 0.487750030821905 2342 3602145 SGTC_2589 lobaric acid 100 µM 0.0305279397875453 0.489168740831582 no 1638 0.487823005516604 2337 73157 A novel microtubule depolymerizer. SGTC_2496 diffractaic acid 79.83 µM 0.0284465705216605 0.490078875792716 no 1639 0.488652990654397 2353 94870 An apoptosis inducer which activates caspases. SGTC_1645 Cervolide 78 µM 0.0272760196235324 0.490590753807478 no 1640 0.489119791659666 2325 23173 A fragrance. SGTC_2305 7443522 69.23 µM 0.0265432152761647 0.490911214652407 no 1641 0.489412032461597 2340 5415886 SGTC_3342 9147791 14.508 µM 0.0261303669402591 0.491091758927342 no 1642 0.48957667800585 2355 1838168 SGTC_499 genistein 192 µM 0.0257430908809799 0.491261121752517 no 1643 0.489731126840441 2365 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_515 4092-1064 102 µM 0.0251530081134827 0.491519178638084 no 1644 0.489966459588458 2362 717353 SGTC_2506 ethyl hematommate 54.16 µM 0.025108218234467 0.491538766437711 no 1645 0.489984322523391 2245 3940691 An allergen. SGTC_1475 4092-1048 11.7 µM 0.0240812243518693 0.491987903548744 no 1646 0.49039390988838 2313 2881759 SGTC_1937 st074714 47.2 µM 0.0222395775355725 0.492793339379272 no 1647 0.49112842354068 2365 17250970 SGTC_735 3076-0345 636 µM 0.0213918932068676 0.493164080325088 no 1648 0.491466520185596 2365 2888990 SGTC_2331 7980721 200 µM 0.0211083717300443 0.493288081851843 no 1649 0.491579603354464 2346 2981221 SGTC_1978 st071761 42 µM 0.0207399590892463 0.493449212516998 no 1650 0.491726546561772 2275 5147680 SGTC_3106 9121286 49.47 µM 0.0198360143039676 0.493844570484922 no 1651 0.492087094134736 2344 15943471 SGTC_3182 9108849 49.47 µM 0.0192771530157594 0.494089002471582 no 1652 0.492310004897284 2347 17133045 SGTC_1118 chelidonine 707.474 nM 0.0191705779088478 0.494135616019607 no 1653 0.492352514357889 2370 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_514 4466-0038 2.65 nM 0.0190216817741371 0.494200739964609 no 1654 0.492411904491704 2290 5722064 SGTC_694 1315-0438 43.2 µM 0.0189458133837106 0.494233923215215 no 1655 0.492442166147004 2348 6793154 SGTC_1876 myriocin 605 nM 0.018868873628934 0.494267575098975 no 1656 0.492472855182255 2376 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1007 4101-0031 70 µM 0.0183647266601244 0.494488079727056 no 1657 0.492673945870967 2375 1146276 SGTC_3274 9138298 49.47 µM 0.0180950630366708 0.494606026340588 no 1658 0.492781508216991 2372 17015756 SGTC_208 k072-0098 12.366 µM 0.0180082980567052 0.494643976074412 no 1659 0.492816116796657 2374 5948901 SGTC_1743 st037606 46.3785 µM 0.017835304128787 0.494719641233822 no 1660 0.492885120306129 2360 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1327 1436-0082 2.18 µM 0.016921259770632 0.495119434725383 no 1661 0.493249716175082 2303 15992205 SGTC_959 1222-0044 107 µM 0.0164078217031252 0.495344009369609 no 1662 0.493454519886651 2375 6083612 SGTC_570 0987-0065 62.6 µM 0.0155442207271824 0.495721746402147 no 1663 0.493799002854087 2379 3104428 SGTC_449 xestospongin c 11.1929 µM 0.0154959633317661 0.495742854189531 no 1664 0.493818252450963 2374 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_175 3793-3120 23.7 µM 0.0154880280671499 0.495746325075849 no 1665 0.493821417783658 2373 5322297 SGTC_3092 9117248 49.47 µM 0.0154284953002637 0.495772364730151 no 1666 0.493845165083964 2382 17141857 SGTC_3161 9100388 49.47 µM 0.0119794695849378 0.497280997013237 no 1667 0.495220997389997 2383 25236368 SGTC_2992 9074591 71.4286 µM 0.0106164440906393 0.497877207520858 no 1668 0.495764731143614 2391 17741321 SGTC_47 0149-0135 24.25 µM 0.0103998101373031 0.497971967363488 no 1669 0.495851150815408 2394 5239155 SGTC_2356 9061756 188.97 µM 0.00950165353834517 0.498364839432389 no 1670 0.496209445706018 2371 20104043 SGTC_85 0868-0259 160.055 µM 0.00921357809208148 0.498490849879558 no 1671 0.496324366149468 2362 83173 SGTC_685 1278-0033 54.9 µM 0.00917987610286416 0.498505591870556 no 1672 0.496337810729318 2388 3590572 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.00735604792253669 0.499303376923932 no 1673 0.497065387933079 2387 688798 SGTC_1030 k029-0042 36.7 µM 0.00723143550606372 0.499357885443859 no 1674 0.497115099772322 2346 6080581 SGTC_3132 9126706 49.47 µM 0.00663397476348327 0.499619229539708 no 1675 0.497353446392048 2381 850858 SGTC_1106 tegaserod maleate 11.7 µM 0.00662835477815574 0.499621687861148 no 1676 0.497355688392517 2359 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_401 neomycin 50 µM 0.00622058908637585 0.499800054754644 no 1677 0.497518360009263 2366 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1016 4226-1401 38 µM 0.00580823847515444 0.499980427246875 no 1678 0.497682861125972 2390 2901613 SGTC_1708 st033234 31.827 µM 0.00571874770809394 0.499980427246875 no 1679 0.497718562183685 2385 674664 SGTC_383 2324-0395 7.37 µM 0.0050703223938868 0.49969678977877 no 1680 0.497977242688714 2392 3146421 SGTC_592 k241-0073 46.5 µM 0.00364896401818894 0.499075052771901 no 1681 0.498544277203958 2401 4230158 SGTC_46 0329-0187a 2.197 µM 0.00351112406826776 0.499014758293128 no 1682 0.498599267035471 2376 46494817 SGTC_1895 st058434 18.3 µM 0.00323932965738785 0.498895869008291 no 1683 0.498707696699588 2400 5393175 SGTC_1771 st048882 4.1505 µM 0.00227509198646094 0.498474089575512 no 1684 0.499092370397787 2397 4580403 SGTC_2853 9015042 58.44 µM 0.00219811991593901 0.498440420312891 no 1685 0.499123077734315 2399 6457456 SGTC_1005 4092-0690 4.4 µM 0.000858104130879897 0.49785427016931 no 1686 0.499657666023217 2403 1529343 SGTC_1221 2958-7315 257 µM 0 0.49747892033254 no 1687 0.5 2406 4562705 SGTC_2803 7707263 71.43 µM 0 0.49747892033254 no 1688 0.5 2406 2199229 SGTC_53 0973-0023 39.979 µM -0.00100540100860029 0.497039143114676 no 1689 0.499598903096485 2407 674768 SGTC_453 enantio-paf c16 10 µM -0.00170032440340081 0.496735175451459 no 1690 0.499321669031939 2412 13871343 A lipid and platelet activating factor SGTC_2242 6630449 61.2675 µM -0.00192553485271999 0.496636666151234 no 1691 0.499231823209556 2424 691249 YDR170C SEC7 SGTC_950 1165-0508 94.1 µM -0.00229860463478056 0.496473482155994 no 1692 0.499082990232776 2410 6148369 SGTC_1777 st045864 34.765 µM -0.00230029733182852 0.496472741756781 no 1693 0.499082314946141 2408 4691462 SGTC_2951 9072950 58.06 µM -0.00301433699059828 0.496160416220489 no 1694 0.498797455348172 2414 16488155 SGTC_2374 9071832 200 µM -0.00324940366434103 0.496057597052033 no 1695 0.498703677773433 2410 17381698 SGTC_1377 2944-0135 198 µM -0.00362777949329003 0.495892094399132 no 1696 0.498552728550692 2411 1894137 SGTC_1692 fluoroquinolonic acid 71 µM -0.00408638899403889 0.495691498262801 no 1697 0.498369771193195 2436 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2974 9094440 9.66 µM -0.0042132721128401 0.495635999682609 no 1698 0.498319152588326 2436 25236134 SGTC_49 0717-0965 32.132 µM -0.00464555690465891 0.49544691928218 no 1699 0.498146697600804 2449 5889349 YGL099W LSG1 SGTC_786 4544-0069 423 µM -0.00480997805947453 0.495375002103268 no 1700 0.498081103783504 2434 748821 YLR208W SEC13 SGTC_1033 k072-0102 21.3 µM -0.00540469166055552 0.495114877940199 no 1701 0.49784385048118 2416 5965931 SGTC_2842 9000675 19.48 µM -0.00638720521502917 0.494685137005854 no 1702 0.497451891111744 2418 2989072 SGTC_219 mitoxanthrone 164.414 µM -0.00674100681030142 0.494530389451447 no 1703 0.497310747738042 2424 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1391 3442-0225 151 µM -0.0075098647854959 0.494194105280274 no 1704 0.49700402557819 2421 5227075 SGTC_333 3486-0131 40.1 µM -0.00787098587547924 0.494036159044834 no 1705 0.496859963368006 2419 6744690 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.00802135862369581 0.49397038966415 no 1706 0.496799975214885 2422 1241132 A phosphatase inhibitor. SGTC_1474 0330-0125 5.35 µM -0.00949674947555657 0.493325098581453 no 1707 0.496211402055743 2421 X1474 SGTC_2179 6298986 200 µM -0.00967806417336301 0.493245798218642 no 1708 0.496139071281168 2431 738374 SGTC_2104 5389443 200 µM -0.0109437837498791 0.492692226758921 no 1709 0.49563414910182 2438 2244536 SGTC_146 3448-8650 53.125 µM -0.0114464109724409 0.492472403012557 no 1710 0.495433642418735 2455 2891488 YIL048W NEO1 SGTC_3275 9138069 49.47 µM -0.0118350127671321 0.492302449789445 no 1711 0.495278623236952 2472 17617007 SGTC_2340 7987427 183.45 µM -0.012209219434422 0.492138793529944 no 1712 0.495129347164553 2440 2239331 SGTC_425 3825-7017 13.1 µM -0.0122358201813358 0.492127159958468 no 1713 0.495118735794565 2503 3397440 SGTC_1050 3232-1156 69.3 µM -0.0122751739245413 0.492109949003486 no 1714 0.495103037101504 2431 700529 SGTC_193 1273-0060 1.558 µM -0.0130306553179118 0.491779549868734 no 1715 0.494801667763814 2428 2847393 YHR072W ERG7 SGTC_2701 st077767 14.721 µM -0.0137473432569722 0.49146612171353 no 1716 0.494515776275547 2445 5721188 SGTC_2524 avocatin b 10.57 µM -0.0157240995872977 0.490601657470019 no 1717 0.493727250341194 2433 6710748 SGTC_510 ag-490 170 µM -0.0165706170077002 0.490231476374515 no 1718 0.493389582785292 2433 5328779 SGTC_335 4077-0256 27.6 µM -0.0166379950165174 0.490202012405963 no 1719 0.493362706553995 2464 3121989 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0168440262769267 0.490111916597432 no 1720 0.493280523490457 2460 5379071 SGTC_841 0251-0215 91.2 µM -0.0182744252732062 0.489486428813759 no 1721 0.492709964867557 2472 3888614 SGTC_2744 captopril 92.04 µM -0.019032031145353 0.489155151752419 no 1722 0.492407776437239 2448 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1091 telmisartan 47.6 µM -0.0190678099745349 0.489139506986422 no 1723 0.492393505339258 2492 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1540 guanosine 70.6 µM -0.019334423928997 0.489022927038468 no 1724 0.492287161366002 2432 6802 Guanosine is a purine nucleoside SGTC_1955 wogonin 32.4 µM -0.021238053692818 0.488190571375867 no 1725 0.491527879331911 2479 5281703 A flavanone. SGTC_253 dyclonine 31.25 µM -0.0216978499438846 0.487989534598041 no 1726 0.491344489433198 2446 3180 An oral anasthetic. SGTC_2790 5423970 71.43 µM -0.0217813439189079 0.487953028841808 no 1727 0.491311188026632 2465 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1567 st069303 68.4 µM -0.022164088321906 0.487785684244577 no 1728 0.491158531958263 2464 5581319 SGTC_2640 pentamidine 10.38 µM -0.0223974736357846 0.487683643906958 no 1729 0.491065447797045 2450 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1314 1222-0010 41.1 µM -0.0231897720052973 0.487337242589798 no 1730 0.490749448586255 2464 3526027 SGTC_1917 st066507 28.5 µM -0.0248415409564333 0.486615102568523 no 1731 0.490090678189946 2428 3156428 SGTC_2490 carminic acid 95.39 µM -0.0252496725850063 0.486436677392839 no 1732 0.489927908287824 2444 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2413 inermin 26.06 µM -0.0256531769983647 0.486260277791556 no 1733 0.489766985447438 2458 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1644 st010134 20.9 µM -0.0259734104114851 0.486120283597867 no 1734 0.489639273355934 2464 3818134 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0293037651603689 0.48466448038233 no 1735 0.488311162014793 2488 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_371 0195-0006 7.36 µM -0.0293823571742395 0.484630127723895 no 1736 0.488279821832659 2436 3928593 SGTC_865 0488-0499 301 µM -0.0306345043284992 0.484082828340308 no 1737 0.487780512290362 2453 9634651 SGTC_106 0092-0003 11.579 µM -0.0309828276460174 0.483930585438127 no 1738 0.487641617325838 2519 1072148 SGTC_586 0957-0265 8.15 µM -0.0309993359059961 0.483923370172625 no 1739 0.487635034644875 2451 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2427 5545055 42.75 µM -0.0315602176752909 0.483678228710418 no 1740 0.487411384634811 2465 5372858 SGTC_942 3253-1115 227 µM -0.0317118017465687 0.483611977762173 no 1741 0.48735094159419 2496 46497897 SGTC_532 1548-0774 215 µM -0.0317433354582268 0.483598195775235 no 1742 0.487338367793581 2534 5932993 SGTC_817 1391-0715 46 µM -0.0319926862961704 0.48348921627343 no 1743 0.487238941701834 2481 1353946 SGTC_1122 capsaicin 818.572 nM -0.0320749547875967 0.483453260862551 no 1744 0.487206138157522 2530 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2557 derrustone 83.84 µM -0.0320885410977549 0.483447322984134 no 1745 0.487200720792563 2515 629853 An antioxidant. SGTC_899 1083-0020 478 µM -0.0331126207558936 0.482999761020523 no 1746 0.486792389180915 2497 767123 SGTC_2799 7812892 81.82 µM -0.0333779180455236 0.482883819432829 no 1747 0.486686609348142 2491 20205235 SGTC_2943 9068529 45.32 µM -0.0336936364711889 0.482745844427613 no 1748 0.486560726726712 2457 3270634 SGTC_1068 loratadine 26.9 µM -0.0342581293495409 0.482499155377892 no 1749 0.486335656597083 2491 3957 A H1 histamine antagonist. SGTC_2717 st081029 62.2815 µM -0.0342636707875176 0.482496733746971 no 1750 0.486333447180277 2462 5292846 SGTC_2827 7993847 71.43 µM -0.0343448730305231 0.482461248110804 no 1751 0.48630107122763 2486 2985692 SGTC_1950 st077106 7.18 µM -0.0346963098565206 0.48230767071555 no 1752 0.486160951732633 2516 13831864 SGTC_415 dibenzyl ketone 100 µM -0.0352627386711225 0.482060147661146 no 1753 0.485935117536587 2548 7593 SGTC_2069 5228469 200 µM -0.0360730881037015 0.481706046072791 no 1754 0.485612040469572 2511 2835210 SGTC_1702 st027038 51 µM -0.0364782419856528 0.481529009776974 no 1755 0.485450513770488 2503 5521182 SGTC_2404 5161160 200 µM -0.0369436070845984 0.481325668046716 no 1756 0.485264985018305 2474 2831543 SGTC_154 3389-1638 511.116 µM -0.0379415954420275 0.480889612517982 no 1757 0.484867124271564 2538 5238686 SGTC_1102 cgs 12066b 26.1 µM -0.0380021683563776 0.48086314685363 no 1758 0.484842976590098 2524 6438352 A 5-HT1B full agonist. SGTC_1651 st011928 86.1 µM -0.0381646693054683 0.480792146962623 no 1759 0.484778195085832 2530 720198 SGTC_426 0988-0037 14.6 µM -0.0395540056321552 0.480185143442625 no 1760 0.484224348453363 2470 5383008 SGTC_1793 st048256 72.231 µM -0.0400192201338011 0.479981900595113 no 1761 0.484038901557833 2476 672022 SGTC_2692 st077426 47.7 µM -0.0412388559606554 0.479449091104379 no 1762 0.483552738714609 2483 25238571 SGTC_478 N-arachidonylglycine 10 µM -0.0414978682779465 0.479335943809308 no 1763 0.483449496129845 2478 5283389 SGTC_295 k015-0027 31 µM -0.0417621797663782 0.479220483333735 no 1764 0.483344142433866 2527 3887424 SGTC_2469 5655019 90.81 µM -0.0422077693769315 0.479025838205244 no 1765 0.48316653450711 2569 2788239 SGTC_2316 5844804 197.44 µM -0.0436070317616498 0.478414636742014 no 1766 0.48260882324806 2498 776813 SGTC_3281 9140613 49.47 µM -0.0438175338361974 0.478322693243553 no 1767 0.482524925263477 2508 16013766 SGTC_1381 2324-0066 62.1 µM -0.0438905248052724 0.478290812377691 no 1768 0.48249583406703 2528 10885928 SGTC_215 1287-0124 461.5 µM -0.0445816869388055 0.477988934722232 no 1769 0.482220369925392 2550 5560863 SGTC_664 1222-0054 14.9 µM -0.0456804570181541 0.477509052935006 no 1770 0.481782470293443 2507 6813991 SGTC_696 1560-0013 611 µM -0.046830460852921 0.477006830024556 no 1771 0.481324175704795 2542 1650269 SGTC_1922 5578187 25 µM -0.0472271472917053 0.476833599886808 no 1772 0.481166095623555 2502 1350412 SGTC_3217 9129673 49.47 µM -0.0490336933442947 0.47604474996848 no 1773 0.480446222409132 2544 17248312 SGTC_913 3487-1245 167 µM -0.0500559505392146 0.475598410543623 no 1774 0.480038901040982 2497 4016153 SGTC_1147 3809-1045 12.3 µM -0.0512124902047656 0.475093477456032 no 1775 0.479578099580844 2503 325925 SGTC_2877 9040724 71.43 µM -0.0520881888441876 0.474711183180653 no 1776 0.479229212063993 2505 6463895 SGTC_2327 6189656 200 µM -0.052124657617955 0.474695262905449 no 1777 0.479214682865581 2537 5349088 SGTC_2544 sphondin 68.51 µM -0.052465962402671 0.474546269835852 no 1778 0.479078708016265 2536 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2416 tofa 880 nM -0.0525303513052539 0.474518161925681 no 1779 0.479053055934301 2550 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3352 9151559 45.5865 µM -0.0530468769696053 0.474292685794014 no 1780 0.478847278922994 2524 17159339 SGTC_1278 0874-0585 172 µM -0.0531911177119251 0.474229722636997 no 1781 0.478789816318633 2537 766306 SGTC_2505 galangin 7.89 µM -0.0533054445267442 0.474179817796465 no 1782 0.478744271133175 2498 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_378 3970-0959 8.33 µM -0.0533235327743276 0.474171922125876 no 1783 0.478737065214893 2566 6615653 SGTC_2346 9031566 143.75 µM -0.0542075301565665 0.473786062336079 no 1784 0.478384910655114 2559 4771086 SGTC_2863 9028737 58.44 µM -0.0543489575454304 0.473724332364122 no 1785 0.478328572341226 2574 6460917 SGTC_3349 9149703 23.001 µM -0.054890327531447 0.473488042010589 no 1786 0.478112918887182 2485 4910494 SGTC_850 0388-0143 75.9 µM -0.055056935489276 0.473415324940595 no 1787 0.478046552287689 2511 67273 SGTC_93 0109-0045 59.227 µM -0.0558245652084633 0.473080299699669 no 1788 0.477740782624348 2482 88733 SGTC_2275 7947463 200 µM -0.056396234170592 0.472830812165511 no 1789 0.477513078439642 2487 1225414 SGTC_145 3737-0113 38.366 µM -0.0573889990806507 0.472397575493163 no 1790 0.477117663011206 2565 6849351 SGTC_751 0833-0568 350 µM -0.0574793821244363 0.4723581344872 no 1791 0.477081664815987 2557 6954252 SGTC_1612 st002233 45.4 µM -0.0580277919987169 0.472118827315341 no 1792 0.476863245503076 2513 1035021 SGTC_2024 5144227 134 µM -0.0580777707645654 0.472097018803224 no 1793 0.476843340429832 2557 3475211 SGTC_264 promethazine 12.5 mM -0.0584594006555645 0.471930495243271 no 1794 0.476691350371359 2497 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3101 9120531 49.47 µM -0.0597419901249326 0.47137087561263 no 1795 0.476180564078729 2511 24824904 SGTC_3079 9117512 49.47 µM -0.0616910545225552 0.470520568116315 no 1796 0.475404431929269 2481 7185044 SGTC_2470 5664817 21.68 µM -0.0618353306879359 0.470457630849995 no 1797 0.475346983745022 2508 2859561 SGTC_2995 9067767 71.4286 µM -0.0619121122193711 0.470424136916422 no 1798 0.475316410923676 2566 11673567 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0621853394294751 0.470304950395586 no 1799 0.475207618666961 2579 688751 SGTC_861 0443-0273 110 µM -0.0625234869371447 0.47015744818223 no 1800 0.475072979328142 2597 6149169 SGTC_2688 kanamycin b 96.69 µM -0.065505266383775 0.468856955490061 no 1801 0.473885856688011 2553 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3035 9091303 49.47 µM -0.0655978646578447 0.46881657432333 no 1802 0.473848994604874 2524 25237002 SGTC_75 0159-0059 199.013 µM -0.0664044707687278 0.468464835204617 no 1803 0.4735279054514 2531 5377270 SGTC_3224 9130643 49.47 µM -0.0671351766699324 0.468146215357589 no 1804 0.473237045060752 2603 17644395 SGTC_1685 st024049 53.0905 µM -0.0672334539607581 0.468103363697119 no 1805 0.473197926479354 2584 1941139 SGTC_1677 st019204 53.9 µM -0.0678692892248215 0.46782613060692 no 1806 0.472944843006347 2641 3945625 SGTC_895 0964-0006 13.7 µM -0.0685612583528381 0.467524440100632 no 1807 0.472669428811649 2508 6738897 SGTC_1149 3909-7961 23.3 µM -0.0685758947230578 0.467518059013979 no 1808 0.472663603455239 2539 735261 SGTC_2237 6667747 47.222 µM -0.0688322381373118 0.467406301133727 no 1809 0.472561578305684 2590 729940 YDL015C TSC13 SGTC_1051 3253-3903 78 µM -0.0691519306938918 0.467266928567984 no 1810 0.472434342604402 2511 5509239 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0695913534927594 0.467075365183179 no 1811 0.47225945958473 2523 688667 SGTC_1907 st060210 83.7 µM -0.0699084299966441 0.466937142568758 no 1812 0.472133271690419 2527 688793 SGTC_1896 st058441 89 µM -0.0701331174550764 0.466839197364613 no 1813 0.472043853836256 2557 688759 SGTC_2000 st075254 36.4 µM -0.0704421318427118 0.466704495854013 no 1814 0.471920879076942 2532 17234175 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0709247302092557 0.466494135519541 no 1815 0.471728830537069 2526 165521 SGTC_218 alverine citrate 93.75 µM -0.0713377848528302 0.466314096106615 no 1816 0.471564461927516 2622 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1125 tnp00248 1.32998 µM -0.0714430849673028 0.46626819971919 no 1817 0.471522560174025 2590 24207736 SGTC_3164 9100705 49.47 µM -0.0721394330587633 0.465964698912075 no 1818 0.471245472457842 2624 17174235 SGTC_467 ro 31-8220 72.8 µM -0.0727444976687081 0.46570099974646 no 1819 0.471004719152949 2570 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_279 1273-0055 2.93 µM -0.0771991279987927 0.463760054511983 no 1820 0.469232567667229 2547 2847562 SGTC_604 1000-0114 314 µM -0.0775594350159827 0.463603100738647 no 1821 0.46908925565195 2568 1572745 SGTC_849 0386-0493 241 µM -0.0780192495858472 0.463402808591409 no 1822 0.468906370354512 2549 726119 SGTC_359 0081-0058 15.9 µM -0.0791940178359609 0.462891129653137 no 1823 0.468439151362501 2702 3494159 SGTC_3267 9137951 49.47 µM -0.0807467657887562 0.462214913217185 no 1824 0.467821672246188 2538 16643986 SGTC_3100 9120536 49.47 µM -0.0809342073365649 0.462133290410567 no 1825 0.467747137834172 2522 16421196 SGTC_428 3448-4153 16.5 µM -0.0819651168389541 0.461684401847617 no 1826 0.46733722640797 2515 3834874 SGTC_143 4032-1194 15.74 µM -0.0821030855665177 0.461624329863438 no 1827 0.467282369741643 2520 1806963 SGTC_1245 0418-0076 17.2 µM -0.0826441386649236 0.461388762236543 no 1828 0.467067251858545 2662 6790114 SGTC_776 4476-4378 112 µM -0.0827314190010654 0.461350762756717 no 1829 0.467032550875203 2644 2892008 SGTC_2303 7774051 200 µM -0.0832995528446722 0.4611034214031 no 1830 0.46680667791932 2636 2953184 SGTC_594 1487-1584 10.8 µM -0.0844864940593915 0.460586726257463 no 1831 0.46633482031328 2570 5013332 SGTC_882 0843-0131 351 µM -0.0855352908783538 0.460130222997025 no 1832 0.465917920100699 2548 5425421 SGTC_1190 1486-1332 13 µM -0.0859810046352993 0.459936235822123 no 1833 0.46574075870202 2548 4150046 SGTC_3029 9088683 49.47 µM -0.0873314231054823 0.459348554092938 no 1834 0.46520403870216 2669 25236615 SGTC_2074 5212007 75.395 µM -0.0877032203703914 0.45918676907527 no 1835 0.465056280001955 2547 758611 SGTC_3051 9093778 49.47 µM -0.0883052871249516 0.458924798222102 no 1836 0.464817018428131 2566 17217378 SGTC_265 mycophenolic acid 32.932 µM -0.0884765384467949 0.458850286723484 no 1837 0.464748965402856 2755 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_442 cape 100 µM -0.0887561612719929 0.458728625861714 no 1838 0.46463784918325 2576 5281787 SGTC_14 0354-0009 295 µM -0.0896850160409778 0.45832451902627 no 1839 0.46426876171011 2544 1713507 SGTC_1872 amphotericin b 148 nM -0.0901565510484026 0.458119389827765 no 1840 0.464081405451588 2624 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1996 st072960 66.8 µM -0.0917047872262435 0.457445948153746 no 1841 0.463466296882932 2543 1719405 SGTC_1203 3992-3522 103 µM -0.0927080595818187 0.457009616400197 no 1842 0.463067746984907 2713 5322312 SGTC_3090 9117696 49.47 µM -0.0931387726423767 0.456822311464147 no 1843 0.462896657590515 2682 7923821 SGTC_1393 3470-5649 58.2 µM -0.0954574728738363 0.455814140122648 no 1844 0.461975733843264 2671 4108395 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0956354918504577 0.455736749109713 no 1845 0.461905037980346 2647 23847180 SGTC_1727 st034309 9.9045 µM -0.0957396545499462 0.455691466756335 no 1846 0.46186367288137 2875 870305 SGTC_2952 9073731 13.78 µM -0.0964092417769048 0.455400392777641 no 1847 0.461597776220094 2594 16457353 SGTC_2909 7941780 10.49 µM -0.0964695372668343 0.455374183103566 no 1848 0.461573833399899 2575 1243215 SGTC_2880 9042983 58.44 µM -0.0966172323509048 0.455309982770707 no 1849 0.461515185541524 2694 6464714 SGTC_2887 9044784 58.44 µM -0.0988310158974526 0.454347832614078 no 1850 0.460636220958056 2598 6465546 SGTC_2251 lansoprazole 556 µM -0.0993694108772351 0.454113876741193 no 1851 0.460422484557503 2592 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_166 k072-0058 166.424 µM -0.099761521458528 0.453943497772529 no 1852 0.460266828515413 2572 5846229 SGTC_1756 st041558 35.5 µM -0.0999508400047675 0.45386123855452 no 1853 0.460191676956271 2656 3955792 SGTC_181 1447-1644 8.07 µM -0.100499470661909 0.453622868827599 no 1854 0.459973901530904 2592 534600 SGTC_2691 st077356 60.2 µM -0.102449401835487 0.452775796112759 no 1855 0.459199986464122 2708 2839272 SGTC_2582 agaric acid 100 µM -0.102688397806369 0.452671988195625 no 1856 0.459105141085859 2611 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1877 wortmannin 25 µM -0.103924133378419 0.452135298118837 no 1857 0.458614777568482 2636 312145 A covalent inhibitor of PI 3-kinase. SGTC_2727 riluzole 51.77 µM -0.104034863615105 0.452087211325159 no 1858 0.458570840755138 2595 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1507 4075-3230 155 µM -0.105484905753916 0.451457566996505 no 1859 0.457995523314194 2549 659771 SGTC_3171 9103192 49.47 µM -0.105860815139958 0.451294357666435 no 1860 0.457846392151682 2599 13018434 SGTC_2970 9090938 41.86 µM -0.105879272599585 0.451286344166096 no 1861 0.457839069841782 2633 17217104 SGTC_2309 7664088 163.95 µM -0.106241555344504 0.451129059322833 no 1862 0.457695350551225 2627 704922 SGTC_2876 9059903 25.97 µM -0.106354355302513 0.451080088851838 no 1863 0.457650603398993 2584 6916095 SGTC_418 lividomycin a 100 µM -0.106555483954459 0.450992773603226 no 1864 0.457570818049051 2602 72394 An antibiotic. SGTC_2102 5377816 72.7585 µM -0.107753628334495 0.450472676833271 no 1865 0.457095563930602 2712 1379702 SGTC_835 0312-0010 67.2 µM -0.107924690055003 0.450398428384771 no 1866 0.457027715839386 2585 1626196 SGTC_1673 st016611 27.3 µM -0.108117387090189 0.450314791319964 no 1867 0.456951288048694 2790 5226799 SGTC_1711 st032263 62.8 µM -0.109679378183169 0.449636915834252 no 1868 0.456331827779382 2647 3958979 SGTC_118 0083-0097 135.343 µM -0.110546299567405 0.44926075113601 no 1869 0.455988066550507 2632 5207356 SGTC_3102 9121669 49.47 µM -0.110602116316299 0.449236533323971 no 1870 0.455965934603676 2635 41905072 SGTC_1038 k292-0204 154 µM -0.111612084224594 0.448798360461746 no 1871 0.455565495034642 2585 4454212 SGTC_1140 3229-1848 2.98 µM -0.112512425464498 0.448407801571816 no 1872 0.455208559101791 2676 2849525 SGTC_581 0958-0271 211 µM -0.113348558142687 0.448045140472509 no 1873 0.454877110716671 2591 4591145 SGTC_2355 9061122 103.12 µM -0.113372301277641 0.448034842845436 no 1874 0.454867699242443 2702 5302957 SGTC_1259 0671-0132 43 µM -0.115806950908471 0.446979098908117 no 1875 0.45390277077823 2642 X1259 SGTC_1416 3966-0321 25.3 µM -0.116819226397606 0.44654025318001 no 1876 0.45350165380337 2649 582530 YLR208W SEC13 SGTC_3306 9127676 59.7925 µM -0.117108171278959 0.446415000623241 no 1877 0.453387167275231 2668 41905287 SGTC_487 nimodipine 119 µM -0.117676044412237 0.446168853133075 no 1878 0.453162174332309 2588 4497 L-type voltage-gated calcium channels inhibitor SGTC_1739 st037196 92.5 µM -0.120739662197276 0.444841272643966 no 1879 0.451948621447723 2677 612214 SGTC_2674 ligustilide 100 µM -0.12449526155031 0.443214675813928 no 1880 0.450461575964721 2716 5319022 A signalling regulator. SGTC_256 clotrimazole 625 nM -0.124502223788229 0.443211661261787 no 1881 0.45045881987623 2618 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2127 5253358 187.912 µM -0.12505554550139 0.442972091184811 no 1882 0.450239788243438 2622 20612 SGTC_1229 0139-0193 12.2 µM -0.125089110023558 0.442957559522015 no 1883 0.450226502260774 2688 3090752 SGTC_2486 5283202 22.39 µM -0.126472127228883 0.442358853165501 no 1884 0.449679105555066 2696 1377751 SGTC_2622 2-methoxyxanthone 59.94 µM -0.126967049630378 0.442144633807828 no 1885 0.449483239013813 2708 71034 A hepatoprotective. SGTC_3300 9124615 50.48 µM -0.127344611085247 0.441981223657789 no 1886 0.449333826577919 2804 24824903 SGTC_1668 st014914 51.6 µM -0.127346009833276 0.44198061829223 no 1887 0.449333273064551 2638 2839556 SGTC_603 3794-0023 45.9 µM -0.128456924716949 0.441499867235431 no 1888 0.448893692417353 2647 3802260 SGTC_3152 9099253 49.47 µM -0.128618850926831 0.441429800462189 no 1889 0.448829624661514 2721 25236131 SGTC_52 0329-0193 875 nM -0.129299222553212 0.441135418243949 no 1890 0.44856044329173 2856 3739292 SGTC_2022 5136654 200 µM -0.129678578708771 0.440971293078413 no 1891 0.448410365576501 2767 1713771 SGTC_720 r052-1644 49.9 µM -0.130003007418627 0.440830939839362 no 1892 0.448282023654708 2747 1422863 YOR257W CDC31 SGTC_3052 9092717 49.47 µM -0.130834312356713 0.440471337501325 no 1893 0.447953189476605 2780 25237534 SGTC_1836 st055642 81 µM -0.131312002113546 0.440264722697098 no 1894 0.447764248844727 2658 8571 SGTC_286 k060-0067 22.9 µM -0.131952496724258 0.439987715561066 no 1895 0.447510932613867 2660 5985051 SGTC_1244 0416-0015 52.5 µM -0.132266537156066 0.439851907123614 no 1896 0.447386737138097 2662 96201 SGTC_2598 perillyl alcohol 100 µM -0.132596228765782 0.439709337867254 no 1897 0.447256357546868 2773 10819 An apoptosis inducer. SGTC_1227 3909-8010 46.6 µM -0.132626920313615 0.43969606625231 no 1898 0.447244220580663 2661 15982272 SGTC_2762 leflunomide 42.06 µM -0.13288342516124 0.439585151279478 no 1899 0.447142787724929 2650 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_551 k048-0028 34.9 µM -0.134682236275902 0.438807463104454 no 1900 0.446431559304028 2773 6836383 SGTC_2207 7258803 200 µM -0.134700019215447 0.43879977609952 no 1901 0.446424528998525 2714 3666799 SGTC_1160 4092-0570 10.5 µM -0.134735915774543 0.438784259217427 no 1902 0.446410337707826 2638 4994975 SGTC_3292 9120825 59.784 µM -0.135150129656437 0.438605215220358 no 1903 0.446246587996202 2658 24824900 SGTC_2976 9009005 19.48 µM -0.135235237053202 0.43856842909323 no 1904 0.446212943923804 2758 2993148 SGTC_762 1165-0429 115 µM -0.13551938737005 0.43844561412311 no 1905 0.446100618375317 2747 5967793 SGTC_2959 9079155 11 µM -0.136201802776779 0.438150685921958 no 1906 0.445830875020214 2802 16189457 SGTC_980 1473-0395 201 µM -0.136258098319593 0.438126357488109 no 1907 0.445808623784818 2651 768876 SGTC_1574 spiramycin 23.7 µM -0.136354599557378 0.438084654482239 no 1908 0.445770481344127 2621 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3273 9137859 49.47 µM -0.136546031136524 0.438001929368661 no 1909 0.445694818850519 2644 2377234 SGTC_2522 biochanin a 4.94 µM -0.136738065438553 0.437918946516985 no 1910 0.445618920120415 2754 5280373 A possible chelator. SGTC_2781 5567276 71.43 µM -0.136799353401187 0.437892463021416 no 1911 0.445594697375065 2801 2853274 SGTC_2073 5212005 126 µM -0.137183577953862 0.43772643987391 no 1912 0.445442845538778 2624 691789 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.138037858441825 0.437357345225973 no 1913 0.445105248611106 2648 364106 SGTC_125 0133-0007 11.75 µM -0.138531281915494 0.437144184831574 no 1914 0.444910274278163 2759 26541 SGTC_3276 9139060 49.47 µM -0.13863006938274 0.437101510544787 no 1915 0.444871240401107 2637 4870619 SGTC_217 ketoconazole 989 nM -0.139021838485948 0.436932281034061 no 1916 0.444716446001601 2716 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1296 1068-0102 11.9 µM -0.140025634407879 0.43649873170324 no 1917 0.444319868294809 2761 767053 SGTC_162 k030-0015 37.8 µM -0.141025329823576 0.436067029224744 no 1918 0.443924966004222 2743 1809920 YMR134W ERG29 SGTC_112 phenothiazine 287.218 µM -0.141909334720921 0.43568534927496 no 1919 0.443575810450895 2642 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_811 0416-0114 265 µM -0.143752524917562 0.434889722365089 no 1920 0.442847946505385 2742 6612453 SGTC_1646 st011709 75.6 µM -0.144921212656104 0.434385385850275 no 1921 0.44238653898135 2676 5757843 SGTC_533 1222-0222 6.71 µM -0.145333921732732 0.434207310486481 no 1922 0.44222361668392 2840 3982874 SGTC_503 tyrphostin 8 294 µM -0.145369314618775 0.434192039814916 no 1923 0.442209645334524 2689 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1046 2001-0062 216 µM -0.145757600902776 0.434024515643194 no 1924 0.442056373964065 2649 739778 SGTC_2051 5263410 176 µM -0.145881436569045 0.433971089856117 no 1925 0.44200749313799 2649 227584 SGTC_2029 5175081 200 µM -0.145928008167095 0.43395099802221 no 1926 0.441989110470358 2657 1380876 SGTC_2283 7944793 200 µM -0.14636779017099 0.433761276493149 no 1927 0.441815526577797 2711 2970533 SGTC_2336 9001819 198.65 µM -0.146499075861882 0.43370464292937 no 1928 0.441763709701883 2848 2989602 SGTC_368 fentichlor 4.58 µM -0.146699898578878 0.433618015359275 no 1929 0.441684449330436 2745 7329 A pesticide. SGTC_810 3825-7150 143 µM -0.146993281871101 0.433491466277766 no 1930 0.441568661505434 2730 22330411 YGL099W LSG1 SGTC_2882 9058044 58.44 µM -0.147495384196769 0.433274903349426 no 1931 0.441370511381592 2751 18076804 SGTC_2017 5132927 60.65 µM -0.147804551216835 0.433141565760712 no 1932 0.441248508720674 2684 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2835 9006588 71.43 µM -0.148058469405314 0.433032061586015 no 1933 0.441148312374683 2904 2345538 SGTC_1236 0330-0013 258 µM -0.149536679669124 0.432394674384616 no 1934 0.440565084268575 2724 4617066 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.150136672627493 0.432136014439994 no 1935 0.440328393655923 2658 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1994 st072947 40.9 µM -0.150895833356673 0.431808778176083 no 1936 0.44002894367605 2776 5286565 YDL195W SEC31 SGTC_3124 9127567 49.47 µM -0.151030821293417 0.4317505965131 no 1937 0.439975701443841 2827 17592030 SGTC_1411 3909-8223 150 µM -0.152072763529673 0.431301554944048 no 1938 0.439564772943182 2711 X1411 SGTC_1887 st057648 70.8 µM -0.15292944576169 0.430932420593586 no 1939 0.439226957337198 2832 688672 SGTC_2563 tomatine 8.54 µM -0.153007767387597 0.430898675726396 no 1940 0.439196074965464 2649 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2064 5220758 200 µM -0.153577960194049 0.430653023415021 no 1941 0.438971257982291 2824 788518 SGTC_3175 9106517 49.47 µM -0.153762584658024 0.430573488651397 no 1942 0.438898468022799 2770 41468073 SGTC_2764 methyldopa 94.69 µM -0.154515918484082 0.430248987600587 no 1943 0.438601480405027 2801 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2190 6049624 200 µM -0.154861357294844 0.430100204422241 no 1944 0.438465309234839 2648 2265554 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.155012409592265 0.430035148142231 no 1945 0.438405767061069 2720 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2511 berberine 10.47 µM -0.155346260366211 0.429891369652167 no 1946 0.438274173872651 2702 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2934 9036370 36.88 µM -0.1554633630385 0.429840939604524 no 1947 0.438228017398808 2780 6462800 SGTC_1930 st074634 34.3 µM -0.157193384925589 0.429096042703442 no 1948 0.437546220777743 2675 684253 YOR116C RPO31 SGTC_2849 9019321 12.99 µM -0.157198918541901 0.429093660493473 no 1949 0.437544040291939 2782 16489627 SGTC_2531 methyl deoxycholate 70.07 µM -0.158918514039271 0.428353503841359 no 1950 0.436866536984908 2696 16667744 Haematoxylin. SGTC_165 k038-0023 64.381 µM -0.159455292944235 0.428122512334611 no 1951 0.436655089322859 2718 46368543 SGTC_2706 st078239 82.5 µM -0.159925256571018 0.427920293594048 no 1952 0.436469976356482 2685 15434492 SGTC_2869 9037858 32.47 µM -0.160660135688499 0.427604123405447 no 1953 0.436180544296094 2655 27187042 SGTC_3089 9117425 49.47 µM -0.160694942118796 0.427589149637348 no 1954 0.436166836633644 2767 9401657 SGTC_3115 9123671 49.47 µM -0.160713074800069 0.427581348977415 no 1955 0.436159695550377 2663 3286988 SGTC_2686 alizarin 95.37 µM -0.160738868829719 0.42757025246245 no 1956 0.436149537280865 2753 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_994 3910-0338 138 µM -0.160813144105206 0.427538299779543 no 1957 0.436120286240684 2835 3479481 SGTC_2385 9074692 200 µM -0.164002132943946 0.426166870957934 no 1958 0.434864732350714 2735 17046906 SGTC_1904 st060225 78 µM -0.164309213053365 0.426034857597512 no 1959 0.434743864648565 2690 66595 SGTC_999 SEC7.066 22.7 µM -0.16488110192573 0.425789025379189 no 1960 0.434518783642577 2723 740511 YDR170C SEC7 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.165835922714119 0.425378650321709 no 1961 0.434143037644612 2716 641818 YHR062C RPP1 SGTC_2756 carbadox 75.1 µM -0.166068745569153 0.425278596986237 no 1962 0.434051425003866 2734 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2751 anetholtrithion 17.25 µM -0.166471283441638 0.425105621644655 no 1963 0.433893040160824 2828 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.167311625285631 0.424744563199252 no 1964 0.433562428708569 2754 4213774 SGTC_2556 citropten 84.59 µM -0.168121254215662 0.424396760466286 no 1965 0.433243944443741 2705 2775 A potential DNA crosslinker. SGTC_3048 9093155 49.47 µM -0.168793857340283 0.424107866424475 no 1966 0.432979395065442 2714 25236002 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.16926967774367 0.423903518396469 no 1967 0.432792262725339 2745 2374 Ca(2+)-ATPase inhibitor. SGTC_2046 4110841 106 µM -0.171783399198475 0.422824304790666 no 1968 0.431803908514585 2793 44119630 YMR134W ERG29 SGTC_249 wiskostatin 11.211 µM -0.172238456375667 0.422628997187234 no 1969 0.431625032903525 2707 2775510 A n-wasp and actin depolymerizer. SGTC_900 1112-0045 141 µM -0.173535663339974 0.422072348870205 no 1970 0.431115198907784 2735 56211 YIL048W NEO1 SGTC_3015 9080845 49.47 µM -0.173803722801765 0.421957340448926 no 1971 0.431009859276795 2826 5296973 SGTC_97 0535-0701 19.132 µM -0.173862766944066 0.421932009002376 no 1972 0.430986657292456 2735 2832013 YGL099W LSG1 SGTC_1647 st011722 22.4 µM -0.175338467059453 0.421299001106636 no 1973 0.4304068437915 2860 2854783 SGTC_1171 0368-0077 21.4 µM -0.175778773144411 0.421110169239169 no 1974 0.430233873271195 2730 3239779 SGTC_1633 st005664 67.9 µM -0.176952281082969 0.420606981504759 no 1975 0.429772936078742 2700 2063822 SGTC_1383 3049-0032 20.7 µM -0.177121405690538 0.420534473343985 no 1976 0.429706514219364 2866 712864 SGTC_759 3486-0358 89.3 µM -0.177874872288909 0.420211475222151 no 1977 0.429410622570061 2741 875103 SGTC_2543 pimpinellin 60.67 µM -0.177942633546189 0.420182429771024 no 1978 0.429384014187248 2730 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2818 7996756 12.99 µM -0.178720900430411 0.41984886160589 no 1979 0.429078428617428 2702 2241621 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.179031133595418 0.41971591052019 no 1980 0.428956627770568 2724 442882 SGTC_1763 st044482 94.5 µM -0.179135227636254 0.419671302848927 no 1981 0.428915760855917 2848 88505 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.17946728274492 0.41952901337011 no 1982 0.428785402409353 2829 7104 SGTC_199 4063-0024 41.6 µM -0.179618836909771 0.419464074142329 no 1983 0.428725907741327 2846 306215 SGTC_1418 3966-3099 2.4 µM -0.179758034188038 0.419404431631661 no 1984 0.428671265365591 2787 740335 SGTC_2907 7721985 69.9 µM -0.179788406280177 0.419391418204936 no 1985 0.428659342876855 2771 3267881 SGTC_1135 dihydrocapsaicin 536.708 nM -0.180453501122145 0.419106469416087 no 1986 0.428398277902568 2707 107982 A Capsaicinoid. SGTC_2463 5473429 200 µM -0.180567404603756 0.419057673620704 no 1987 0.428353571313745 2793 5399405 SGTC_332 4112-0506 40.9 µM -0.181305742013804 0.418741403055819 no 1988 0.42806379962337 2732 2790355 SGTC_2302 7771753 200 µM -0.18141245442627 0.418695696592741 no 1989 0.428021921926659 2793 2203047 SGTC_1629 st005085 44.9 µM -0.182152059276084 0.418378943381318 no 1990 0.427731697326322 2735 24207091 SGTC_12 0849-0099 9.267 µM -0.182548280747762 0.418209273953183 no 1991 0.427576234134501 2713 6071388 SGTC_1736 st036774 51 µM -0.183639355230163 0.417742134247815 no 1992 0.427148193556667 3012 1272247 SGTC_1926 methyl fluorone black 53.6 µM -0.184277274924457 0.417469064889295 no 1993 0.426897970305514 2728 72721 Reacts with homocysteine. SGTC_1472 k841-0093 193 µM -0.184450152494844 0.417395069370863 no 1994 0.426830164342952 2840 X1472 SGTC_2661 dactinomycin 12.96 µM -0.184615156346305 0.417324446711001 no 1995 0.426765448623489 2722 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2446 5162541 200 µM -0.184731280537009 0.417274746444417 no 1996 0.426719905046877 2708 1549321 SGTC_470 aa-861 153 µM -0.185444888609143 0.416969356687648 no 1997 0.426440051466316 2749 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_435 c-PAF 6.7 µM -0.185551951130005 0.416923543421547 no 1998 0.426398068263498 2870 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_493 zm226600 134 µM -0.186003065093825 0.416730519041903 no 1999 0.42622117883912 2913 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.186808215368254 0.416386058159417 no 2000 0.425905502689319 2882 5282362 SGTC_2858 9025781 8.96 µM -0.187018764213069 0.416295991341891 no 2001 0.425822960396125 2846 4894980 YPL153C RAD53 SGTC_334 1502-1024 68.5 µM -0.187265653508759 0.416190384710013 no 2002 0.425726175553095 2838 3296216 SGTC_463 ikarugamyin 104 µM -0.187524243028321 0.416079779807424 no 2003 0.425624808819254 2719 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1463 k081-0032 34.1 µM -0.189103861797028 0.415404283811546 no 2004 0.425005707410118 2809 977755 SGTC_2010 4012422 159 µM -0.189422634123968 0.415267996715781 no 2005 0.424880793058735 2826 952393 SGTC_1570 verbenone 133 µM -0.18995565002612 0.415040135258042 no 2006 0.424671941922999 2903 29025 A natural terpanoid with antifungal properties. SGTC_2671 danthron 100 µM -0.191920197396942 0.414200549058758 no 2007 0.423902358146555 2779 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_554 4483-2211 187 µM -0.192506752798648 0.413949949402471 no 2008 0.42367263943478 2859 747107 SGTC_3318 9139014 38.6185 µM -0.194358338506645 0.413159109111065 no 2009 0.422947654449393 2738 16643984 SGTC_2768 sulfasalazine 50.2 µM -0.194614764810821 0.413049613251102 no 2010 0.422847271710917 2806 5384001 An antioxidant and salicylic acid derivative. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.194872591726812 0.412939526139146 no 2011 0.422746345728022 2770 688669 SGTC_1165 k072-0275 30.3 µM -0.196595217947992 0.412204174107949 no 2012 0.422072156553943 2781 6153523 YGL055W OLE1 SGTC_1832 st054113 55 µM -0.197832232277269 0.411676309256246 no 2013 0.421588163412981 2773 1251267 SGTC_840 0245-0196 390 µM -0.198751239685047 0.411284249296185 no 2014 0.421228670016014 2884 3827528 SGTC_2875 9039966 71.43 µM -0.199243867207315 0.411074124727889 no 2015 0.42103599309545 2856 6463691 SGTC_649 1123-0311 367 µM -0.199447711773504 0.410987184646113 no 2016 0.42095627075397 2857 693629 YIL048W NEO1 SGTC_2306 7482397 179.52 µM -0.199849454942243 0.410815853250404 no 2017 0.420799160991886 2907 891448 SGTC_2387 9077560 195.08 µM -0.200985085252975 0.410331633155585 no 2018 0.420355118176086 2760 5303272 SGTC_3054 9094397 49.47 µM -0.201776839154945 0.409994118936716 no 2019 0.420045594400208 2803 2598354 SGTC_2431 5490079 200 µM -0.201818373001656 0.409976415445387 no 2020 0.420029358757249 2796 5722345 SGTC_1948 st076329 66.6 µM -0.202786512439949 0.409563805318544 no 2021 0.419650950213742 2716 24208413 SGTC_1263 0774-1208 64.8 µM -0.20347441790935 0.409270688585813 no 2022 0.419382119494687 2886 906585 SGTC_1505 k297-0037 20.6 µM -0.205727621676636 0.408310953730872 no 2023 0.418501840537139 2785 4089396 SGTC_1321 1326-2144 215 µM -0.205949595804017 0.408216435207483 no 2024 0.418415141954988 2890 3513030 SGTC_3257 9139206 32.98 µM -0.206330142306677 0.408054407608516 no 2025 0.418266517450258 2875 4910041 SGTC_2217 6934799 96.0675 µM -0.209040498283515 0.406900859166938 no 2026 0.417208311937737 2843 675606 SGTC_2923 7992654 58.14 µM -0.209197341142779 0.406834130246631 no 2027 0.417147093983753 2816 2985126 SGTC_1023 4482-3888 16 µM -0.20940726460868 0.406744822372577 no 2028 0.417065161072721 2987 3303168 SGTC_3314 9135860 59.4275 µM -0.210000370753669 0.406492523068782 no 2029 0.416833691833956 2812 25252478 SGTC_2058 5236698 133 µM -0.211193320978939 0.405985175882639 no 2030 0.4163682111534 2801 766665 SGTC_293 4049-0273 38.5 µM -0.211239178562389 0.405965676356629 no 2031 0.416350320187331 2802 1380311 SGTC_1502 4534-4282 27.7 µM -0.211956266857745 0.405660787004093 no 2032 0.416070576543298 2807 3278949 SGTC_2940 9060638 45.86 µM -0.212219717189824 0.4055487883817 no 2033 0.415967812485146 2888 4027022 SGTC_1408 3909-7976 48.8 µM -0.213082671265976 0.405181981515245 no 2034 0.415631240298708 2816 24152374 SGTC_2057 5236571 38.335 µM -0.213249303512097 0.405111162471242 no 2035 0.415566256963101 2923 54684039 YBR257W POP4 SGTC_9 0092-0002 10.449 µM -0.213323833101122 0.405079488249616 no 2036 0.415537192619963 2818 759368 SGTC_55 0767-0285 6.563 µM -0.213425512597379 0.405036276631237 no 2037 0.41549754135846 2903 3116166 SGTC_855 0428-0020 25 µM -0.215143329345605 0.404306416548549 no 2038 0.414827786425316 2800 6812414 SGTC_1484 3473-2379 286 µM -0.215213117790853 0.404276772094005 no 2039 0.414800582015442 2775 671917 SGTC_269 exalamide 29 µM -0.21601857283823 0.40393467396307 no 2040 0.4144866351546 2810 3316 A derivative of salicylamide. SGTC_3062 9077494 49.47 µM -0.21609985767136 0.403900154214276 no 2041 0.414454955327189 2906 16459633 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.216960546286906 0.403534686055901 no 2042 0.414119546033663 2889 16725076 SGTC_147 4466-0538 29.23 µM -0.217460759006317 0.403322322919828 no 2043 0.413924642513092 2995 6742687 YHR072W ERG7 SGTC_3353 9151644 39.2805 µM -0.217837721188334 0.403162304096022 no 2044 0.413777776494244 2905 4909158 SGTC_2108 5365811 200 µM -0.218229185875375 0.402996146183994 no 2045 0.413625273004475 2900 780283 SGTC_1129 3453-1384 223 µM -0.218255864908971 0.402984822855924 no 2046 0.413614880086968 3013 1084452 SGTC_3104 9120930 49.47 µM -0.219387526421974 0.402504589093065 no 2047 0.413174092919276 2877 17014836 SGTC_3307 9126885 69.2785 µM -0.221023746551198 0.401810500248387 no 2048 0.412536971555816 2803 24824909 SGTC_693 4161-2696 114 µM -0.221677947945288 0.40153307282627 no 2049 0.412282299007138 2902 805759 SGTC_544 k015-0020 52.4 µM -0.222514638412274 0.401178329531466 no 2050 0.411956639542959 2833 3008304 SGTC_1396 3511-0007 98.6 µM -0.222976994132438 0.400982333067905 no 2051 0.411776705894929 2930 X1396 SGTC_2600 tangeritin 87.95 µM -0.223820760063974 0.400624717885427 no 2052 0.411448387769384 2791 68077 A bioactive flavone. SGTC_2662 daunorubicin 22.37 µM -0.224313966147253 0.400415719806043 no 2053 0.411256504834662 2780 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2987 9018338 71.43 µM -0.22701647916126 0.399271026582845 no 2054 0.410205464080519 2763 5055682 SGTC_2253 7938677 135.83 µM -0.227939189546537 0.398880395340245 no 2055 0.409846757847733 3010 2301972 SGTC_1182 1222-0449 220 µM -0.22837833045164 0.398694519721127 no 2056 0.409676067073919 2875 658318 SGTC_228 caffeine 993.056 µM -0.228572885644082 0.398612177488182 no 2057 0.409600450400848 2944 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_565 1418-0001 44.5 µM -0.228760428258246 0.398532807483809 no 2058 0.409527562450111 2985 2862145 SGTC_2160 5660466 132.927 µM -0.229484571961984 0.3982263816772 no 2059 0.409246155246207 2778 2859134 SGTC_177 1327-0068 8.361 µM -0.229939766339288 0.398033795520146 no 2060 0.409069287519072 2814 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2408 sulbentine 18.36 µM -0.230557474294212 0.397772491952762 no 2061 0.408829304055526 2886 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2630 antimycin a 100 µM -0.230936009162006 0.397612386327023 no 2062 0.408682257738147 2756 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_698 k064-0052 127 µM -0.231115787136361 0.397536353227498 no 2063 0.408612425372296 2785 5088751 SGTC_1480 1070-0044 41.2 µM -0.232216523763345 0.397070906112805 no 2064 0.408184922199203 2904 3124987 SGTC_2110 5483698 200 µM -0.232521757861557 0.396941863627451 no 2065 0.408066394963462 2867 2848765 YHR062C RPP1 SGTC_755 1995-0008 37.3 µM -0.234221063475601 0.396223662259198 no 2066 0.407406681740688 2850 689533 SGTC_2553 4-methylesculetin 85.09 µM -0.234462059477688 0.396121835187407 no 2067 0.407313142238974 2866 5319502 SGTC_2499 avocadenofuran 51.48 µM -0.235986095363479 0.395478054824454 no 2068 0.40672172989767 2806 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_753 1322-0200 289 µM -0.23685716991575 0.39511022508999 no 2069 0.406383799006755 2984 5403907 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.237464472921489 0.394853833761506 no 2070 0.406148238766755 2951 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3034 9090421 49.47 µM -0.237830133491518 0.394699481046285 no 2071 0.406006422994048 2809 17173761 SGTC_1511 0906-3109 28.5 µM -0.239019504617453 0.394197537893203 no 2072 0.405545229263348 2798 2882180 SGTC_643 k048-0106 28.4 µM -0.242336832224642 0.392798476751042 no 2073 0.404259588084652 2948 6763920 SGTC_1020 4335-0961 93.3 µM -0.242523177851655 0.392719927591226 no 2074 0.404187399749426 2803 669075 SGTC_3073 9114972 49.47 µM -0.242525316697071 0.392719026041841 no 2075 0.404186571202149 2957 41905075 SGTC_648 0375-0473 33.3 µM -0.244774106145641 0.39177145324236 no 2076 0.403315672207592 2849 1713139 SGTC_1380 2291-0730 164 µM -0.245240944637969 0.39157482167333 no 2077 0.403134937460353 2936 2999191 SGTC_2177 5811945 192 µM -0.245632178108999 0.391410056140211 no 2078 0.402983488843859 2996 5343475 SGTC_2773 thioridazine 9.09 µM -0.245718141765302 0.391373855692767 no 2079 0.402950213791753 2814 5452 An antipsychotic. SGTC_1345 1488-0192 31.4 µM -0.246063745061639 0.39122832701191 no 2080 0.402816443798216 2977 658348 SGTC_1726 st035556 14.5795 µM -0.246134163248493 0.391198676771793 no 2081 0.402789188970079 3048 5919439 SGTC_2142 5622915 118.518 µM -0.246679594283283 0.390969039331046 no 2082 0.402578100010965 2871 5322196 SGTC_3023 9089636 49.47 µM -0.247082992202912 0.39079922513723 no 2083 0.402421997994945 2885 17249241 SGTC_2090 5301565 104.445 µM -0.248763925003906 0.390091844977012 no 2084 0.401771698841791 2860 2056344 SGTC_2043 5101342 149 µM -0.249381769916619 0.389831931104675 no 2085 0.401532742638367 2878 678451 SGTC_721 1187-1332 279 µM -0.249705970358653 0.389695566749657 no 2086 0.401407370381842 2790 25730 SGTC_2436 5633522 8.09 µM -0.250638606224049 0.389303359619045 no 2087 0.40104676537805 2999 5724242 SGTC_1681 tripelennamine 100 µM -0.255906067255972 0.387090329118675 no 2088 0.399011684797517 2835 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_623 k072-0108 16.9 µM -0.257991621692784 0.386215129143209 no 2089 0.398206686663833 2933 5382803 SGTC_2917 7979103 53.79 µM -0.259801841866339 0.385455941709854 no 2090 0.39750831506318 3016 2980565 SGTC_191 3914-0123 66.505 µM -0.259881129303342 0.385422699394041 no 2091 0.397477733957398 2851 3144412 SGTC_2111 5486399 200 µM -0.261293130155248 0.384830840386789 no 2092 0.39693323197417 2873 689674 SGTC_319 1348-1596 45.5 µM -0.262152669241807 0.384470684371436 no 2093 0.396601871012536 3070 5380505 SGTC_2255 7941087 197.44 µM -0.262902208866333 0.384156700665308 no 2094 0.396312976879027 3023 935561 SGTC_3044 9093193 49.47 µM -0.263870568049916 0.38375116554785 no 2095 0.395939827689539 2973 25236277 SGTC_284 0988-0104 32.6 µM -0.264699825950877 0.383403985230353 no 2096 0.395620355791756 2961 4666532 SGTC_2363 9053361 176 µM -0.264979926378914 0.383286738437101 no 2097 0.395512462835032 3033 6469797 YMR079W SEC14 SGTC_119 0121-0043 24.815 µM -0.265375592999851 0.383121135191248 no 2098 0.395360068140635 2865 1092378 SGTC_408 cantharidin 100 µM -0.265546565098383 0.383049582730341 no 2099 0.39529422158964 2919 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2326 6164455 177.58 µM -0.26613863263517 0.382801831106428 no 2100 0.395066221500408 2955 2888790 SGTC_1037 k284-1091 78.7 µM -0.267652932640461 0.382168388162321 no 2101 0.394483241274986 2850 3334711 SGTC_2822 7994718 71.43 µM -0.267981681118282 0.382030911822189 no 2102 0.394356709765884 2809 1018011 SGTC_609 0986-0026 86.3 µM -0.26817263555386 0.381951065148609 no 2103 0.394283218716157 2898 2848610 SGTC_2271 7849410 118.62 µM -0.27023366952836 0.381089573996638 no 2104 0.393490245695499 2917 972430 SGTC_2158 5657123 3.6195 µM -0.270437156608096 0.381004550354629 no 2105 0.393411978906677 2852 2858827 SGTC_725 1497-0963 19 µM -0.271007569232976 0.380766243701245 no 2106 0.393192605318712 3013 3549977 SGTC_32 0928-0142 34.1 µM -0.271114098420795 0.380721743008728 no 2107 0.393151639276279 2950 2244242 SGTC_1238 0333-0287 48.8 µM -0.273097968664237 0.379893305058638 no 2108 0.392388954085293 2895 7226 SGTC_2023 5144124 124 µM -0.273310673110676 0.379804515129138 no 2109 0.392307205803535 2892 2830192 SGTC_3236 9132701 49.47 µM -0.274452373057196 0.379328039885521 no 2110 0.391868499803884 2952 24282524 SGTC_2342 7990637 118.86 µM -0.27481720223005 0.379175821254985 no 2111 0.391728340655264 3006 2033102 YER133W GLC7 SGTC_1310 1188-0297 994 nM -0.276238187340859 0.37858311868466 no 2112 0.391182564301235 2935 1588352 SGTC_552 k242-0005 476 µM -0.276267909528187 0.378570724401287 no 2113 0.391171150795037 3016 4088318 SGTC_302 1094-0063 18.9 µM -0.276298810857284 0.378557838543026 no 2114 0.39115928459038 2873 5440289 SGTC_758 0868-0029 16 µM -0.276451292481937 0.378494255662959 no 2115 0.391100732664875 3002 762687 SGTC_2027 5150920 200 µM -0.277162301003456 0.378197817691716 no 2116 0.390827742747728 2963 786715 SGTC_1949 st076024 69.1 µM -0.277465471081989 0.378071439979297 no 2117 0.390711357716319 2829 2921930 SGTC_995 3931-2021 34.6 µM -0.277974014368112 0.377859480889211 no 2118 0.390516153228208 2994 730143 SGTC_616 4092-0450 108 µM -0.278367961516422 0.37769531034367 no 2119 0.390364955464927 2957 787165 SGTC_625 k213-0058 121 µM -0.27848293749801 0.377647400288755 no 2120 0.390320830560398 2955 3655420 SGTC_1322 1348-1070 12 µM -0.279915034124462 0.377050809024298 no 2121 0.389771346276348 2972 6758089 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.280074603594602 0.376984352773325 no 2122 0.389710134334826 2848 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1985 st071382 65.5 µM -0.280217061325969 0.376925026164892 no 2123 0.389655488884719 2917 6123237 SGTC_172 1112-0046 2.638 µM -0.280726257672822 0.376712994801942 no 2124 0.389460183780401 2930 2802135 YIL048W NEO1 SGTC_896 0964-0007 44.5 µM -0.281038985707641 0.376582792044291 no 2125 0.389340249029316 2991 6756758 SGTC_2985 9022375 71.43 µM -0.281065118100105 0.376571912588406 no 2126 0.389330227437226 3097 4939335 SGTC_3077 9117319 49.47 µM -0.283835007098407 0.375419307977085 no 2127 0.388268412764002 2883 17154678 SGTC_283 0987-0079 11.7 µM -0.289068671710448 0.37324451904885 no 2128 0.386264413503241 3011 411556 SGTC_3247 9135149 49.47 µM -0.289171826313488 0.373201694638836 no 2129 0.386224945311685 2892 8934436 YOR116C RPO31 SGTC_827 3253-0474 693 µM -0.290141547571382 0.372799193599145 no 2130 0.385853975904066 3049 5402065 SGTC_3025 9087895 49.47 µM -0.290308505166943 0.372729908707554 no 2131 0.385790116360225 3057 17173641 SGTC_4 0960-0234 25.671 µM -0.291013885981306 0.37243723174579 no 2132 0.385520349716794 2997 6821112 SGTC_1148 3909-7663 27.7 µM -0.291941168761949 0.372052595182481 no 2133 0.385165802890688 3049 4084526 SGTC_1971 st069429 63.5 µM -0.292262350583155 0.371919398820957 no 2134 0.38504302129554 3069 1246522 YGL099W LSG1 SGTC_3218 9131285 49.47 µM -0.293044184129373 0.371595231042165 no 2135 0.384744189655668 3095 17156417 SGTC_2156 5649887 115 µM -0.293822292745675 0.37127269809646 no 2136 0.38444684972408 3025 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2635 hydroquinidine 100 µM -0.295643011276096 0.370518347588739 no 2137 0.38375136143598 2894 442912 An experimental heart treatment. SGTC_2414 st077232 92.9 µM -0.295712752224263 0.370489462763059 no 2138 0.383724728826144 2882 729801 SGTC_2864 9034755 47.6 µM -0.295848075862198 0.370433417433479 no 2139 0.383673053125356 2904 4930451 SGTC_3200 9114385 49.47 µM -0.299242098101882 0.369028659231273 no 2140 0.382377665196366 3066 17018030 YLR208W SEC13 SGTC_2528 xanthyletin 44.79 µM -0.29961648913351 0.368873808509965 no 2141 0.382234852593572 2921 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3348 9149464 3.537 µM -0.299863137347188 0.368771804729927 no 2142 0.382140776630661 2902 1951442 SGTC_122 0236-0016 402.397 µM -0.300333777074582 0.368577192722919 no 2143 0.381961285677271 2981 6808838 SGTC_2890 9046729 58.44 µM -0.300824701801047 0.368374228675764 no 2144 0.381774085534348 2958 903329 SGTC_1965 Pectolinarigenin 58.4 µM -0.301645896499787 0.368034802533427 no 2145 0.38146100817385 2944 5320438 An anti-inflammatory. SGTC_1193 1488-0126 41.5 µM -0.303367235728279 0.367323652263515 no 2146 0.380805005981183 2963 1384710 SGTC_652 0437-0092 114 µM -0.303979761464409 0.367070704336061 no 2147 0.380571655014403 2958 3091274 SGTC_1745 st081495 74 µM -0.304493961657526 0.366858405349935 no 2148 0.380375796194468 2942 13842402 YBL026W LSM2 SGTC_1109 tnp00067 928.257 nM -0.306051872020325 0.366215436200489 no 2149 0.379782575622398 2967 676295 SGTC_3271 9137798 49.47 µM -0.307976451407362 0.365421656648325 no 2150 0.379050125532531 3058 6498326 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.308808589718867 0.36507862510326 no 2151 0.378733567325194 2995 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_796 1234-0020 70.7 µM -0.309217264404778 0.364910197051363 no 2152 0.378578130960665 2936 46495034 SGTC_1760 st045453 10.4495 µM -0.309608766926692 0.364748870646687 no 2153 0.378429244320672 3080 3323419 YIL048W NEO1 SGTC_2180 6301957 200 µM -0.309642782048216 0.364734855169219 no 2154 0.37841630937542 3082 845462 SGTC_2488 5268135 45.7 µM -0.310327710088394 0.364452678190373 no 2155 0.37815588049694 3086 1270356 YLR208W SEC13 SGTC_819 1013-0258 27.7 µM -0.311247296915084 0.364073941883674 no 2156 0.377806314818019 2973 5753198 SGTC_1821 st053465 65.6 µM -0.31135107938528 0.364031206896368 no 2157 0.377766869910578 3025 675086 SGTC_2377 9073351 62.6 µM -0.31146875412317 0.363982753471317 no 2158 0.377722146470173 2930 7337946 YHR072W ERG7 SGTC_804 1595-0054 20.9 µM -0.311512391691572 0.363964785939349 no 2159 0.377705562000125 2968 761523 Stimulates phospholipase C. SGTC_1187 1391-0724 117 µM -0.311548431338019 0.363949947036003 no 2160 0.377691865292416 2997 6997986 SGTC_1028 k015-0029 4.8 µM -0.312064132899399 0.363737635299132 no 2161 0.377495892054875 2939 4588309 SGTC_3227 9130768 49.47 µM -0.312181582876345 0.363689287581169 no 2162 0.377451263957712 2958 17720899 SGTC_2814 7977482 42.97 µM -0.312759248458606 0.363451525927217 no 2163 0.377231789096655 3105 6456762 SGTC_142 0335-0849 62.6745 µM -0.313121957356795 0.36330226526919 no 2164 0.377094003871884 3031 3889043 YPR107C YTH1 SGTC_1716 st033144 30.6155 µM -0.314889845370039 0.362575047852536 no 2165 0.376422645959232 3129 674617 SGTC_2956 9076196 2.52 µM -0.315922705721024 0.362150411813999 no 2166 0.37603058860551 3091 16423868 SGTC_3291 9121177 71.43 µM -0.31619710600452 0.362037627137168 no 2167 0.375926452113595 3008 17015612 SGTC_189 3970-0742 2.116 µM -0.316792966420537 0.361792756388453 no 2168 0.375700350766363 2995 2891807 SGTC_2735 sertaconazole 140 nM -0.316900176134261 0.361748704215499 no 2169 0.375659674188305 2990 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1811 st050069 61.5 µM -0.319637538969629 0.360624551475437 no 2170 0.374621557036435 3002 3877702 SGTC_155 k072-0202 43.6 µM -0.319939279052555 0.360500709344613 no 2171 0.374507180592925 2984 5857737 SGTC_779 1360-0071 233 µM -0.320016135506129 0.360469167755714 no 2172 0.374478049443092 3169 7566 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.320312100881486 0.360347713589197 no 2173 0.374365875424315 2942 2346 DNA damaging agent; causes G2/M arrest. SGTC_522 1273-0010 11.6 µM -0.32104186208933 0.360048304533005 no 2174 0.374089333633495 3201 5705015 SGTC_3040 9091894 49.47 µM -0.321550355360232 0.35983972881429 no 2175 0.373896679246132 2961 25236966 SGTC_1850 st056238 17 µM -0.322240320647612 0.359556782946908 no 2176 0.373635320378972 2943 5393177 SGTC_2386 9075165 157.42 µM -0.322824326184032 0.359317349950589 no 2177 0.373414144466883 2959 16452277 SGTC_2871 9038510 12.99 µM -0.323447548273204 0.359061899712166 no 2178 0.373178162362321 3180 4945164 SGTC_1346 1488-2224 62.4 µM -0.324123913378702 0.358784738169068 no 2179 0.372922111558524 3083 3722427 SGTC_1885 st057546 99.9 µM -0.324265259254394 0.358726826706576 no 2180 0.37286860949055 3136 702008 SGTC_2361 9034121 116 µM -0.325754264459371 0.358116957148581 no 2181 0.372305142225377 3003 6496917 SGTC_1368 1852-0141 284 µM -0.326508282895144 0.357808262772151 no 2182 0.372019911772495 3091 2838987 SGTC_3066 9117245 49.47 µM -0.326724715936786 0.357719672470566 no 2183 0.371938052341561 3023 17176980 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.327113434999604 0.357560581357427 no 2184 0.371791045327643 3057 17037758 SGTC_620 0109-0052 432 µM -0.327859338437723 0.357255374662117 no 2185 0.371509009550649 3138 493037 SGTC_1928 4'-methoxychalcone 40.3 µM -0.328742361524835 0.356894179757864 no 2186 0.371175216210222 3192 641818 SGTC_511 blebbistatin 171 µM -0.331307924556313 0.355845481359204 no 2187 0.370205953040635 3126 3476986 A myosin inhibitor. SGTC_38 0929-0051 58.268 µM -0.331960853885988 0.355578763930184 no 2188 0.369959409240402 3119 1379719 SGTC_3067 9117431 49.47 µM -0.332901901971701 0.35519447625145 no 2189 0.369604166844301 3021 17150885 SGTC_2728 chlorpromazine 9.18 µM -0.333586231175286 0.354915115075528 no 2190 0.369345904801532 2967 2726 A thorazine and dopamine antagonist. SGTC_1870 st057514 26.5 µM -0.333603192083307 0.35490819217667 no 2191 0.369339504597186 2955 5393161 SGTC_2926 9010726 65.15 µM -0.3338707835931 0.354798976243303 no 2192 0.369238533644719 3107 2994293 SGTC_2334 9017922 200 µM -0.334519357212722 0.354534314182113 no 2193 0.368993843229802 3121 3163164 SGTC_2290 7904846 200 µM -0.340281405180532 0.35218610358327 no 2194 0.36682230952619 3067 2962154 SGTC_1114 scopoletin 1.73284 µM -0.340960567241715 0.351909693138524 no 2195 0.366566633812771 3143 5280460 A coumarin with genotoxic properties. SGTC_2616 abietic acid 100 µM -0.341600285168672 0.351649407517006 no 2196 0.366325861283182 3169 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_80 0159-0065 512.242 µM -0.341734567251601 0.351594780237848 no 2197 0.366275327815918 3022 1548079 SGTC_351 caspofungin 25 nM -0.342409225323164 0.351320369059202 no 2198 0.366021473419345 3041 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3320 9137005 35.139 µM -0.342792320990787 0.351164582781211 no 2199 0.365877351650471 3048 4908713 SGTC_2709 st078560 56 µM -0.343299232159072 0.35095848523281 no 2200 0.3656866792008 3184 17250903 SGTC_647 0140-0236 81 µM -0.345053097571724 0.350245745489142 no 2201 0.365027226548734 3051 990837 SGTC_3139 9095020 49.47 µM -0.34529443673657 0.35014771074004 no 2202 0.364936514311579 2898 25236292 SGTC_3142 9086498 49.47 µM -0.345996150089411 0.349862723436497 no 2203 0.364672804023837 3109 25236367 SGTC_1899 st063254 59.6 µM -0.346136790026086 0.349805615414334 no 2204 0.364619957948513 2977 3093813 SGTC_571 k831-0106 44.2 µM -0.346473956924869 0.349668719815502 no 2205 0.364493276480096 3146 4783639 SGTC_2883 9059145 45.46 µM -0.347250301590729 0.349353584776729 no 2206 0.364201641965787 2951 16476510 SGTC_2537 larixol 68.93 µM -0.348751133275943 0.34874465934632 no 2207 0.363638076319056 3056 6708759 SGTC_1768 st044301 37.178 µM -0.349756239792701 0.34833707979153 no 2208 0.363260821390211 3066 3931349 SGTC_3084 9116877 49.47 µM -0.350469320760993 0.348048025301088 no 2209 0.36299325520884 3094 27241325 SGTC_2456 5770359 74.46 µM -0.350963667143347 0.347847688853462 no 2210 0.3628078030623 3178 3118787 SGTC_573 3702-0553 84.7 µM -0.350973919659262 0.34784353441731 no 2211 0.36280395721074 3032 1222756 SGTC_340 k038-0059 454 µM -0.352091380307978 0.347390836239317 no 2212 0.362384866273071 3057 23733424 SGTC_3194 9111903 49.47 µM -0.352939092899609 0.347047561697267 no 2213 0.362067051226845 3225 17087251 SGTC_190 3970-0790 3.722 µM -0.353549297017175 0.346800541990809 no 2214 0.361838339073013 3111 2832352 SGTC_1057 3448-5381 134 µM -0.355677742201019 0.345939425913955 no 2215 0.361040957792401 3151 5497911 SGTC_2476 5806916 10.51 µM -0.356201926006887 0.345727476174899 no 2216 0.360844674836363 3008 2870194 SGTC_878 0828-0289 13.7 µM -0.360240078349123 0.344096305037751 no 2217 0.359333802821139 3049 745350 YLR208W SEC13 SGTC_3256 9138902 49.47 µM -0.36064361934799 0.343933457407662 no 2218 0.359182938576797 3046 17228773 SGTC_2961 9083290 32.55 µM -0.360766255168117 0.343883973863341 no 2219 0.359137095389913 3110 17741490 SGTC_1780 st038448 24.544 µM -0.361929929672022 0.343414564461513 no 2220 0.358702196681758 3205 728868 YDL195W SEC31 SGTC_3285 9112818 20.8695 µM -0.362131466430402 0.343333291965791 no 2221 0.358626895175304 3039 17017947 YPR165W RHO1 SGTC_2310 7668677 200 µM -0.363338335486455 0.342846756958695 no 2222 0.358176079822672 3268 2197143 SGTC_469 w7 172 µM -0.363499514958133 0.34278179906013 no 2223 0.358115887592125 3085 45115570 A P450 inhibitor. SGTC_1407 3909-7909 12.3 µM -0.364699636811751 0.34229827706421 no 2224 0.357667814872667 3061 4411780 SGTC_1292 0kpi-0043 232 µM -0.364778485761401 0.342266518326699 no 2225 0.357638383000701 3093 3333905 SGTC_2353 9059630 146.67 µM -0.365409363160859 0.342012454052808 no 2226 0.357402926493496 3144 4779114 SGTC_1578 josamycin 24.2 µM -0.365586382564073 0.341941178392596 no 2227 0.357336868934539 3050 5282165 A P450 substrate. SGTC_894 0960-0238 55.9 µM -0.367870190394661 0.341022124587876 no 2228 0.35648501430415 3172 6741907 YDL195W SEC31 SGTC_1942 st076330 65.2 µM -0.368426440682985 0.340798419935857 no 2229 0.356277642525107 3184 24208414 SGTC_1721 st082152 9.2685 µM -0.368916974220929 0.340601190732156 no 2230 0.356094805406202 3013 5296051 SGTC_834 0312-0008 75.7 µM -0.369783507434449 0.340252889551916 no 2231 0.355771902370638 3057 6385573 YIL048W NEO1 SGTC_546 peri-Naphthalide 147 µM -0.371138784321813 0.339708412166108 no 2232 0.355267082472749 3084 223824 A penicillin ester. SGTC_2787 5284540 71.43 µM -0.371620970022881 0.339514776443871 no 2233 0.355087536863957 3097 736958 SGTC_549 1661-1316 519 µM -0.37191544258655 0.339396543232673 no 2234 0.354977903526689 3200 2857282 SGTC_62 0180-0423 3.232 µM -0.372686211019756 0.339087148086845 no 2235 0.354691000154997 3098 30102 YGL099W LSG1 SGTC_1779 st039427 55 µM -0.372837252238607 0.339026531143675 no 2236 0.354634787686944 3268 1124498 SGTC_1269 0831-0796 3.05 µM -0.373931748317541 0.338587404734796 no 2237 0.354227547657005 3188 927758 SGTC_2741 miltefosine 3.04 µM -0.377662271337895 0.33709232023409 no 2238 0.352840749346885 3071 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1206 3978-0017 132 µM -0.378013745656959 0.336951591700076 no 2239 0.352710191378588 3317 3873677 SGTC_3284 9108171 64.8615 µM -0.378342925330599 0.336819810522866 no 2240 0.352587930665347 3140 8687505 SGTC_2092 5303694 80.6725 µM -0.378881939667328 0.33660406906168 no 2241 0.352387768084868 3075 1963699 SGTC_1770 st043884 66.3 µM -0.379043595859789 0.336539376357054 no 2242 0.352327745140969 3047 670149 SGTC_2497 7-hydroxyflavone 100 µM -0.379442640762067 0.336379704494307 no 2243 0.35217959551678 3217 5281894 SGTC_1964 st076914 61 µM -0.379768070391721 0.336249510525444 no 2244 0.352058792942353 3085 24208661 SGTC_2593 nobiletin 86.24 µM -0.379829521970205 0.336224927921324 no 2245 0.352035983207162 3128 72344 An anti-infammatory. SGTC_148 3253-0744 288.01 µM -0.379882885263557 0.336203581458993 no 2246 0.352016176131745 3115 6893655 SGTC_64 000l-0018 272.079 µM -0.382944822265594 0.334979627392638 no 2247 0.350880338259567 3010 6811119 SGTC_1268 0828-0275 2.46 µM -0.385753098204459 0.333858608109543 no 2248 0.349839766974103 3185 745337 SGTC_439 amiodarone 34.4 µM -0.385842546954356 0.333822925873773 no 2249 0.349806641343508 3094 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2314 7727897 200 µM -0.387907855121593 0.332999466827318 no 2250 0.349042112439129 3064 900724 SGTC_1638 st008370 60.6 µM -0.388795326089917 0.332645870192815 no 2251 0.348713779297368 3138 24207134 SGTC_356 1634-0012 32.5 µM -0.390909557737947 0.331804093212395 no 2252 0.347932044472729 3215 735457 SGTC_1334 1486-0610 236 µM -0.391109954012832 0.331724349804018 no 2253 0.347857981632033 3173 3742339 SGTC_1775 st081588 35.1725 µM -0.391460116165459 0.331585028572637 no 2254 0.3477285819644 3143 1426443 YGL099W LSG1 SGTC_3223 9129970 49.47 µM -0.39266498538214 0.331105817721649 no 2255 0.347283467621318 3044 17248386 SGTC_1003 4049-0218 100 µM -0.392926426581557 0.331001871583278 no 2256 0.347186911285346 3250 295161 SGTC_978 1416-0512 87.4 µM -0.393040975427792 0.33095633232818 no 2257 0.34714460884785 3186 6814003 SGTC_2922 7999257 32.47 µM -0.393127968146022 0.33092174976954 no 2258 0.347112484052198 3151 2988377 SGTC_1936 st074407 74.3 µM -0.393474968556768 0.330783819683722 no 2259 0.34698435417646 3101 809813 SGTC_3317 9138495 8.753 µM -0.394410341919299 0.33041213018008 no 2260 0.346639054800903 3112 17020139 SGTC_567 1080-0542 68.4 µM -0.394600498120611 0.330336588215023 no 2261 0.346568872928565 3178 5950415 SGTC_637 1181-0519 7.26 µM -0.394795154656944 0.330259265596014 no 2262 0.346497035550116 3133 6252091 YGR060W ERG25 SGTC_2030 5175110 200 µM -0.394807688779997 0.330254286965971 no 2263 0.34649241006084 3226 2831986 SGTC_1217 1183-1422 255 µM -0.394877969768708 0.330226371485748 no 2264 0.3464664745691 3232 2849664 SGTC_1925 st057770 10.1 µM -0.396970985212428 0.329395463279089 no 2265 0.345694428426761 3102 5989122 SGTC_1156 4092-0367 4.88 µM -0.398917940848382 0.32862329498513 no 2266 0.344976834637881 3143 1357585 SGTC_624 k048-0052 28 µM -0.400763700249749 0.327891936433805 no 2267 0.344297053372343 3143 6835531 SGTC_2867 9039098 71.43 µM -0.400980563816415 0.327806050265848 no 2268 0.344217216882767 3069 6463460 SGTC_1483 3453-0561 55.9 µM -0.401863381506026 0.327456515139458 no 2269 0.343892286695209 3188 4546991 SGTC_109 0132-0036 33.701 µM -0.402876742446163 0.327055480250098 no 2270 0.343519450806392 3036 67274 A color developer. SGTC_187 1488-2104 32.728 µM -0.403148438557986 0.326947991154429 no 2271 0.343419514195297 3186 2852859 SGTC_2155 5570423 76 µM -0.403798116338601 0.326691022226083 no 2272 0.343180590884022 3103 797402 SGTC_1913 st060213 96.1 µM -0.406210067087914 0.325737736174309 no 2273 0.342294128896233 3281 688959 SGTC_2011 4012611 177 µM -0.407893785208772 0.325072946988858 no 2274 0.341675827813886 3094 2049887 SGTC_673 1082-0474 110 µM -0.409319999953573 0.324510264101257 no 2275 0.341152420071787 3152 3098046 SGTC_798 1287-0182 476 µM -0.409694252596252 0.324362676893865 no 2276 0.341015123340796 3291 1649755 SGTC_710 3448-4187 58 µM -0.409883204658786 0.324288173784201 no 2277 0.340945813187339 3164 3946412 SGTC_2453 5731132 22.18 µM -0.410089274955395 0.324206929036325 no 2278 0.340870229955073 3268 1362040 SGTC_2657 nystatin 74.44 µM -0.410461413881676 0.324060231702967 no 2279 0.340733751634935 3185 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2018 5133068 143 µM -0.4108652528773 0.32390106909288 no 2280 0.340585671208607 3081 785362 SGTC_2136 5328288 199.296 µM -0.411299931369557 0.323729787872947 no 2281 0.340426309953291 3137 262395 SGTC_1596 piperlongumine 63 µM -0.413478980393473 0.322871716050087 no 2282 0.33962785974913 3263 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2131 toluylene red 5.2905 µM -0.413676184281632 0.322794106989588 no 2283 0.339555635459127 3114 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1909 st060837 51.5 µM -0.415735082206552 0.321984294666805 no 2284 0.338801933454813 3141 678937 SGTC_2062 5245942 200 µM -0.41698743449708 0.321492128290264 no 2285 0.338343799344588 3189 1376160 SGTC_770 0389-1121 67.2 µM -0.418120256319609 0.321047206352822 no 2286 0.337929597748353 3300 6753108 SGTC_2619 obliquin 87.91 µM -0.41897566374977 0.320711410552297 no 2287 0.337616959074786 3111 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1476 4112-3294 3.34 µM -0.42229981770004 0.319407886403418 no 2288 0.336403095603955 3269 704369 SGTC_1658 st012944 20 µM -0.42253452498752 0.319315933017275 no 2289 0.336317453032967 3210 24207260 SGTC_1546 5-methoxyflavanone 78.7 µM -0.423857939237308 0.318797655221547 no 2290 0.335834710182816 3219 147795 SGTC_521 r062-0005 13.8 µM -0.424450676770537 0.318565641094361 no 2291 0.335618584585247 3142 2832033 SGTC_674 0498-0004 451 µM -0.425415744897067 0.318188038503448 no 2292 0.335266815126442 3214 4231473 SGTC_489 paxilline 115 µM -0.42608761389361 0.31792526753994 no 2293 0.335022002633881 3221 105008 A toxic potassium channel blocker. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.428045151849773 0.317160188597442 no 2294 0.334309123914885 3246 616764 SGTC_1807 st050092 58.9 µM -0.428185495697109 0.31710536693991 no 2295 0.334258037655487 3151 5008496 SGTC_2540 epiandrosterone 100 µM -0.429205245000123 0.316707149116515 no 2296 0.333886933165968 3184 441302 A steroid. SGTC_1335 1486-0900 202 µM -0.43030913186616 0.316276314408456 no 2297 0.333485392605724 3140 X1335 SGTC_2440 5628896 157.78 µM -0.430559377932444 0.316178680805924 no 2298 0.3333943917109 3140 5522048 SGTC_156 3474-0145 5.642 µM -0.430975323281874 0.316016427918105 no 2299 0.333243156685586 3280 2265471 SGTC_2618 avocadyne 43.43 µM -0.431971444171981 0.31562800294365 no 2300 0.332881083841426 3155 3015189 SGTC_1464 k208-0027 110 µM -0.433706757427771 0.314951825497325 no 2301 0.332250699469057 3350 X1464 SGTC_2704 st078022 71.1 µM -0.434369491373289 0.314693749806084 no 2302 0.332010074271499 3325 54697681 SGTC_518 1021-0119 62.6 µM -0.435696917707838 0.314177108016584 no 2303 0.331528321180985 3170 1097762 SGTC_582 0987-0078 156 µM -0.435932319321425 0.314085526345207 no 2304 0.331442917660491 3306 1625765 SGTC_929 2805-0021 398 µM -0.437767507601041 0.313371949536687 no 2305 0.330777413566398 3246 3098024 SGTC_3341 9147222 25.867 µM -0.438134499225936 0.313229335743611 no 2306 0.330644393505734 3299 1939759 SGTC_881 0833-0569 170 µM -0.43849652550642 0.313088678858887 no 2307 0.330513194142198 3194 5418700 SGTC_531 3788-1495 174 µM -0.438517620389584 0.313080483771345 no 2308 0.33050554993794 3107 2896655 SGTC_889 0919-1524 82.7 µM -0.439187537225213 0.312820277846144 no 2309 0.33026282733551 3240 3905452 SGTC_1460 k062-0059 9.15 µM -0.440480238234967 0.312318436659525 no 2310 0.329794661023351 3089 1373085 SGTC_2485 5633444 17.78 µM -0.440713592594853 0.3122278829002 no 2311 0.329710177476791 3226 5724239 SGTC_2227 7312221 64.1025 µM -0.441249580705701 0.31201993428632 no 2312 0.329516161393956 3232 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1809 st050081 57.6 µM -0.441342792098707 0.311983776946695 no 2313 0.329482425571246 3333 5036894 SGTC_1303 1160-0052 261 µM -0.442619360743295 0.311488769619732 no 2314 0.329020539257312 3248 3562476 SGTC_1440 4100-1550 40 µM -0.443198439487857 0.311264335970385 no 2315 0.328811103765292 3216 742806 SGTC_3258 9138477 49.47 µM -0.445439518111187 0.310396422324202 no 2316 0.32800107952087 3223 4970355 SGTC_1886 st057356 49.9 µM -0.446763336016716 0.309884235941516 no 2317 0.327522973093007 3170 24207747 SGTC_2266 7929956 200 µM -0.446834900490847 0.309856558078362 no 2318 0.327497135112552 3241 2967153 SGTC_1121 fusaric acid 630.51 nM -0.446880761068422 0.309838821872571 no 2319 0.327480577824378 3170 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2712 st079126 47.7 µM -0.447127756835053 0.309743305878917 no 2320 0.327391409465253 3159 3152970 SGTC_2254 7938975 95.19 µM -0.447556241370999 0.309577636643632 no 2321 0.327236744899932 3371 2969277 SGTC_353 1988-1175 58.3 µM -0.44781134290842 0.309479022569372 no 2322 0.327144678253952 3087 2788357 SGTC_2048 5246248 200 µM -0.447878088519029 0.309453223120333 no 2323 0.327120591367581 3301 677046 SGTC_1773 st048542 73.5835 µM -0.448371868523723 0.309262389530951 no 2324 0.326942420406679 3170 3237138 SGTC_16 erodoxin 22.806 µM -0.448944413071952 0.309041179826147 no 2325 0.326735878167796 3318 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3172 9105863 49.47 µM -0.45021309359927 0.308551256072091 no 2326 0.326278397983822 3237 2348785 SGTC_2096 5468907 200 µM -0.452767539300964 0.307565845081313 no 2327 0.325358070074228 3276 759785 SGTC_1231 0242-0792 125 µM -0.452913783385234 0.307509471415121 no 2328 0.325305412706341 3167 3707635 SGTC_2808 7946468 45.46 µM -0.452961789991012 0.307490966985005 no 2329 0.325288127970871 3240 2970879 SGTC_1803 st050068 52.4 µM -0.453026348331432 0.307466083363274 no 2330 0.32526488439073 3322 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2710 st078562 53.7235 µM -0.453259645254314 0.307376167862995 no 2331 0.325180893851303 3165 17250908 SGTC_3166 9102297 49.47 µM -0.454787797617685 0.30678748560594 no 2332 0.324630954886633 3252 25237072 SGTC_2874 9043904 71.43 µM -0.454883609027279 0.30675059324441 no 2333 0.324596487778428 3239 4463428 SGTC_151 3013-0144 2.285 µM -0.455080284541943 0.306674869105129 no 2334 0.324525740616855 3333 906558 YHR107C CDC12 SGTC_3296 9122258 64.045 µM -0.457349174836085 0.305801896724251 no 2335 0.323710044817222 3285 4730474 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.457478112451893 0.305752320076102 no 2336 0.323663715427147 3321 756377 SGTC_766 1391-0721 126 µM -0.45759520412138 0.305707301291006 no 2337 0.323621644846585 3328 1020919 YIL115C NUP159 SGTC_2832 7992762 51.95 µM -0.459428396558715 0.305002868374383 no 2338 0.32296328013683 3088 2985177 SGTC_3220 9131269 49.47 µM -0.459631131682146 0.304925008517587 no 2339 0.322890504737286 3314 17722206 SGTC_1560 lithocholic acid 53.1 µM -0.461698520638414 0.304131538280801 no 2340 0.322148766054396 3271 9903 A bile acid which acts as a detergent. SGTC_2482 5981709 142.65 µM -0.462252521297192 0.303919067531778 no 2341 0.321950121584861 3233 877755 SGTC_380 3970-0968 6 µM -0.462332222352857 0.303888505970292 no 2342 0.321921547871577 3159 2891601 SGTC_2957 9076800 11.52 µM -0.462514405146706 0.303818652687753 no 2343 0.32185623727163 3225 16459615 SGTC_1559 coumarin 343 70.1 µM -0.462644609109132 0.303768733733956 no 2344 0.321809563903392 3353 108770 A hepatotoxic, DNA x-linker. SGTC_2715 st079500 56.4 µM -0.463245620929553 0.303538359001366 no 2345 0.321594159551676 3186 28246688 SGTC_577 r071-0003 38.6 µM -0.463694886732399 0.303366201238735 no 2346 0.32143318056753 3207 4568517 YMR134W ERG29 SGTC_830 4076-0286 57.8 µM -0.464695389010997 0.302982967633007 no 2347 0.321074805431943 3254 6866659 SGTC_2823 7987624 58.44 µM -0.465400386291528 0.302713054808852 no 2348 0.320822378803248 3426 2239440 SGTC_3017 9080681 49.47 µM -0.465639430681845 0.302621559558362 no 2349 0.320736806956103 3282 16451914 SGTC_140 0062-0056 502.533 µM -0.466158822150874 0.302422803007293 no 2350 0.320550910778224 3183 3758964 SGTC_663 1486-0733 13.9 µM -0.466182872619575 0.302413600985575 no 2351 0.320542303928874 3208 722445 YPR165W RHO1 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.466456684900013 0.30230884570435 no 2352 0.320444322578327 3324 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2205 7238770 200 µM -0.466830350070223 0.302165914912955 no 2353 0.320310629928745 3337 279867 SGTC_2971 9092186 9.93 µM -0.466907863677685 0.302136268955882 no 2354 0.320282899464913 3166 25236400 SGTC_2902 5787006 60.46 µM -0.46735279298108 0.30196612596891 no 2355 0.32012374559186 3170 591003 SGTC_61 0978-8327 98.565 µM -0.467645521838845 0.301854208602821 no 2356 0.320019052774506 3326 6150059 YHR072W ERG7 SGTC_13 0199-0087 65 µM -0.468322845521923 0.301595322769188 no 2357 0.319776866750214 3295 4589825 SGTC_860 0443-0016 25.1 µM -0.46891110005395 0.301370561911239 no 2358 0.319566590897351 3289 5337942 SGTC_395 anisomycin 6.25 µM -0.469690053874025 0.301073054583656 no 2359 0.319288237451423 3267 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2774 tamoxifen 10.92 µM -0.470046075373304 0.300937122697417 no 2360 0.319161049670563 3320 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1093 fluphenazine 7.97 µM -0.470535795093036 0.300750188977747 no 2361 0.318986133312799 3251 6602611 An atypical antipsychotic. SGTC_2182 6325192 200 µM -0.471286939812362 0.300463567088169 no 2362 0.318717920424133 3320 736248 SGTC_1600 coumarin 106 71.1 µM -0.472517813892916 0.299994156969662 no 2363 0.318278614813935 3372 100336 A hepatotoxic, DNA x-linker. SGTC_3249 9135183 49.47 µM -0.472671814775444 0.299935450057956 no 2364 0.318223669034537 3365 4902779 SGTC_134 0269-0018 6.916 µM -0.472820297127085 0.299878851797661 no 2365 0.318170695991809 3266 4378915 SGTC_1388 3346-4487 254 µM -0.4733443335462 0.299679139103384 no 2366 0.317983768797947 3316 3345614 SGTC_888 0916-0002 6.97 µM -0.473592424673984 0.299584611450147 no 2367 0.317895289248889 3374 2802138 YIL048W NEO1 SGTC_2938 9059746 27.26 µM -0.47394535024683 0.299450163076186 no 2368 0.317769439317511 3306 6471769 SGTC_2958 9077254 16.72 µM -0.474707418458134 0.299159943568731 no 2369 0.317497764790912 3405 16457351 SGTC_2664 lyso-paf C-16 73.48 µM -0.474913568421399 0.299081457131672 no 2370 0.31742428996492 3225 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1069 diphenylcyclopropenone 8.49 µM -0.475826768304241 0.298733891622014 no 2371 0.317098898870022 3261 65057 A dermal irritant. YDR527W RBA50 SGTC_1323 1348-1351 11.2 µM -0.47644420724334 0.298498997343132 no 2372 0.316878973308426 3244 6989654 SGTC_1355 1499-0035 1.68 µM -0.476796191647003 0.298365128401742 no 2373 0.316753628936793 3240 1548538 SGTC_2153 5569715 200 µM -0.478417273487249 0.297748941325805 no 2374 0.316176620842443 3301 2054701 SGTC_1026 k007-1105 30.6 µM -0.47880011426216 0.297603505053445 no 2375 0.316040417696339 3318 7066794 SGTC_1343 1487-0095 224 µM -0.479813378529788 0.297218735590979 no 2376 0.315680049490865 3361 4560101 YGL055W OLE1 SGTC_8 0354-0001 70 µM -0.480517411831931 0.296951525151603 no 2377 0.315429762629187 3290 4993152 SGTC_2380 9035439 200 µM -0.48136896760306 0.296628470635684 no 2378 0.31512714403027 3380 6462575 SGTC_2533 agelasine 13.65 µM -0.481924721100192 0.296417721409594 no 2379 0.314929711982931 3444 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1349 flufenamic acid 69 µM -0.483380304498591 0.295866070097046 no 2380 0.3144128650642 3252 3371 A non-steroidal anti-inflammatory. SGTC_186 3455-3465 67.277 µM -0.483461950080693 0.295835141221985 no 2381 0.314383885201949 3260 755278 SGTC_2719 novobiocin 32.65 µM -0.483741505181032 0.295729251765976 no 2382 0.314284666595576 3366 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2233 sulbentine 40.3845 µM -0.486244243162909 0.294782045348955 no 2383 0.313397003008776 3297 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1170 0310-0127 64.8 µM -0.487410642375501 0.294341078864399 no 2384 0.312983676594472 3292 774975 SGTC_1786 berberine 21.6 µM -0.487839016441285 0.294179205160035 no 2385 0.312831936481686 3317 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_722 3534-0461 190 µM -0.487856010831894 0.294172784179467 no 2386 0.31282591732482 3304 658262 SGTC_313 3474-0040 5.03 µM -0.49069029883936 0.293102814030214 no 2387 0.311822754469443 3235 1043375 YIL048W NEO1 SGTC_1232 0279-0259 161 µM -0.49097630250612 0.292994945311435 no 2388 0.31172160417938 3292 1560000 SGTC_1515 3460-0031 42.1 µM -0.491127230865053 0.292938028820998 no 2389 0.311668231402092 3309 2876596 SGTC_2149 5554786 194.827 µM -0.491247500312027 0.292892677765605 no 2390 0.311625703364376 3276 745063 YPR165W RHO1 SGTC_2063 5246145 200 µM -0.49138334517843 0.292841457469581 no 2391 0.311577670781509 3367 711240 SGTC_2813 7971799 71.43 µM -0.49159653157299 0.292761083940766 no 2392 0.311502297929257 3337 2234054 SGTC_704 1310-0270 142 µM -0.491934261772353 0.292633777050152 no 2393 0.311382908315466 3307 5718033 SGTC_1280 0880-0253 10.1 µM -0.49271757489548 0.292338607386511 no 2394 0.311106078879923 3280 6836607 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.493884329876827 0.291899205262797 no 2395 0.310693935967792 3314 6312947 SGTC_670 4204-0025 119 µM -0.494030485414311 0.291844184498848 no 2396 0.310642324913205 3340 719039 SGTC_2222 6885208 172.143 µM -0.495598043300005 0.291254375854424 no 2397 0.31008901680068 3317 609514 SGTC_2798 7813637 45.45 µM -0.496879038748346 0.290772802595202 no 2398 0.309637176943336 3375 956368 SGTC_387 norethindrone acetate 66.7 µM -0.497602530615453 0.290500980039802 no 2399 0.309382109866656 3308 541197 SGTC_2009 4012297 12.05 µM -0.498966602383297 0.289988809462917 no 2400 0.308901456140576 3336 45595307 SGTC_422 cantharidin 155 µM -0.499616070773642 0.289745101216351 no 2401 0.30867271986578 3252 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1712 st032288 53.4 µM -0.499959946902258 0.289616103149302 no 2402 0.308551640174129 3383 2883011 SGTC_323 4013-0906 34.3 µM -0.500541404542042 0.289398042615621 no 2403 0.308346954765212 3357 2910086 SGTC_1273 0849-0096 14.1 µM -0.50070310950049 0.289337413096563 no 2404 0.308290041777253 3323 5286025 SGTC_1889 st059080 5.18 µM -0.501597309933206 0.289002250158042 no 2405 0.30797540602641 3411 176925 Isolated from Daphnopsis sellowiana. SGTC_413 propylparaben 100 µM -0.502328050188851 0.28872849082052 no 2406 0.307718390562681 3287 7175 A pharmaceutical preservative. SGTC_3197 9113331 49.47 µM -0.506080250613606 0.28732471996797 no 2407 0.306400157086759 3458 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_639 0833-0042 114 µM -0.507758966480539 0.286697727101597 no 2408 0.305811194860278 3279 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2328 6201408 200 µM -0.508957611523736 0.286250435886833 no 2409 0.305390968123719 3374 2890418 SGTC_2441 5730946 39.09 µM -0.50964405735588 0.285994428310457 no 2410 0.305150426030023 3389 1774275 SGTC_2908 7930301 100 µM -0.510333076879032 0.285737570367292 no 2411 0.304909066683115 3276 2223178 SGTC_72 0744-0168 198.391 µM -0.510869596702976 0.285537638445201 no 2412 0.304721185810205 3193 677577 SGTC_2913 7966556 36.57 µM -0.511667237015275 0.285240524187359 no 2413 0.304441959804681 3376 2976516 SGTC_273 hydroxyurea 18.1 mM -0.512083454271247 0.285085545296626 no 2414 0.304296301915015 3320 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_555 4296-0685 37 µM -0.512399815613859 0.284967774708106 no 2415 0.304185610003868 3356 2908540 YHR072W ERG7 SGTC_2100 5377183 190 µM -0.5138653282305 0.284422517023065 no 2416 0.303673074875457 3342 2844202 SGTC_1412 3909-8563 178 µM -0.514706487443889 0.284109781190685 no 2417 0.303379069690221 3423 23767530 SGTC_788 1182-0090 188 µM -0.515107658290422 0.283960687232031 no 2418 0.303238895733008 3457 5715185 SGTC_1444 4112-3581 28 µM -0.515255534921372 0.283905738764999 no 2419 0.303187233150398 3382 2877249 SGTC_812 4251-0442 148 µM -0.516261255305283 0.283532165062087 no 2420 0.30283597640009 3396 5723007 SGTC_407 eburnamonine 100 µM -0.516691047476038 0.283372591118176 no 2421 0.302685923271544 3310 3195 SGTC_2236 dapsone 200 µM -0.518295349531961 0.282777323863027 no 2422 0.302126108553756 3388 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1783 st039459 87.517 µM -0.518770223346902 0.282601239898009 no 2423 0.30196049245522 3461 729761 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.520239439488368 0.282056786254145 no 2424 0.301448349873267 3311 6708784 An antioxidant flavonoid SGTC_1753 st043925 64 µM -0.52119655932757 0.281702374224968 no 2425 0.301114925381256 3382 670181 SGTC_3001 9076041 71.4286 µM -0.522046143391874 0.281387961609641 no 2426 0.300819101606518 3366 16004211 SGTC_3019 9081971 49.47 µM -0.524487632541121 0.280485363315992 no 2427 0.299969709769446 3468 16451803 SGTC_3039 9090270 49.47 µM -0.525044913256909 0.280279537871486 no 2428 0.299775984556304 3444 17173750 SGTC_741 4582-0002 126 µM -0.525248020064354 0.28020454082182 no 2429 0.299705393458328 3317 2912688 SGTC_1277 0873-0036 22 µM -0.527531565257479 0.279362013131705 no 2430 0.298912251177579 3420 5965735 SGTC_306 1672-3436 11.6 µM -0.529723451095136 0.278554463068734 no 2431 0.298151842998604 3413 6797378 SGTC_1602 st001878 87.6 µM -0.531811115779877 0.277786369644482 no 2432 0.297428411597471 3454 595405 YLR310C CDC25 SGTC_1052 3253-3998 198 µM -0.532072924652508 0.277690117973075 no 2433 0.297337744452586 3350 5450317 SGTC_617 3770-0098 35 µM -0.53381443396304 0.277050282664397 no 2434 0.296734963221693 3344 5962639 SGTC_2558 carylophyllene oxide 100 µM -0.533973261748372 0.276991964823791 no 2435 0.296680016685142 3449 6708694 An oxygenated terpenoid and antifungal agent. SGTC_740 k014-0057 261 µM -0.534001323594102 0.276981661796373 no 2436 0.296670309162618 3398 4012779 SGTC_1696 st025591 34.7925 µM -0.534118270251219 0.276938726348201 no 2437 0.296629855004213 3393 2787147 SGTC_1866 st057638 64 µM -0.535174416711096 0.276551123543836 no 2438 0.29626462758532 3350 688802 SGTC_397 arbidol 50 µM -0.536927129854657 0.275908470171833 no 2439 0.295658975082507 3451 131410 A RNA synthesis inhibitor. SGTC_3206 9114350 49.47 µM -0.53696363237676 0.275895093884909 no 2440 0.295646367635742 3383 17087243 SGTC_2988 9073640 71.4286 µM -0.536974233619204 0.275891209137406 no 2441 0.295642706165196 3495 9102229 SGTC_1719 st032227 49.2 µM -0.537210249395271 0.275804729847248 no 2442 0.295561196135394 3345 3125804 SGTC_2838 9002687 71.43 µM -0.538003138823937 0.27551430229251 no 2443 0.295287440806535 3310 6457060 SGTC_100 0086-0128 49.5915 µM -0.539283438269731 0.275045659042341 no 2444 0.294845647388087 3383 93297 SGTC_3235 9132602 49.47 µM -0.53942309812481 0.274994561445227 no 2445 0.294797473344943 3478 4912240 SGTC_2072 5231554 129 µM -0.540174639306285 0.274719674073521 no 2446 0.294538300278822 3477 789545 SGTC_2680 butyl paraben 22.24 µM -0.540865033339408 0.274467271642816 no 2447 0.294300306840526 3423 7184 An antifungal and steroid mimetic. SGTC_1663 st014140 55.4 µM -0.541251524597581 0.274326023570358 no 2448 0.294167113910127 3470 4207120 SGTC_558 k064-0027 21.3 µM -0.541948162346063 0.274071519251569 no 2449 0.293927108418861 3396 5088526 SGTC_3313 9133968 57.047 µM -0.542203447148836 0.273978284667826 no 2450 0.293839180429974 3405 1494643 SGTC_633 0437-0093 97.7 µM -0.542345333101901 0.27392647215405 no 2451 0.293790315776778 3408 2831118 SGTC_2148 5546263 113.568 µM -0.542398854857665 0.27390692886506 no 2452 0.293771884188561 3326 792097 SGTC_15 0266-0086 27.098 µM -0.542867152465082 0.273735960975919 no 2453 0.293610636732513 3475 1712902 YIL048W NEO1 SGTC_2473 5854593 8.94 µM -0.543403273728781 0.273540296592283 no 2454 0.293426086091615 3332 2872951 SGTC_377 3970-0964 33.1 µM -0.543508929119807 0.273501744458425 no 2455 0.29338972235725 3417 16481235 SGTC_2694 st077685 81.9 µM -0.543992670525699 0.273325268524565 no 2456 0.293223258290242 3331 2838096 SGTC_3191 9110352 49.47 µM -0.544820482431636 0.273023401534009 no 2457 0.292938495035972 3425 17122424 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.546036463526034 0.272580286025086 no 2458 0.292520436346133 3343 4174840 SGTC_1801 st050089 28.441 µM -0.547239601073412 0.272142202492358 no 2459 0.292107066418033 3436 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1404 3909-7820 48.3 µM -0.547472367024863 0.272057488741066 no 2460 0.292027124877271 3449 23741373 SGTC_785 1270-0111 65.3 µM -0.548151155807371 0.271810522591301 no 2461 0.29179405866218 3418 6741994 SGTC_901 1112-0062 60.1 µM -0.550874424834518 0.270820828867574 no 2462 0.290859880302177 3401 1908457 SGTC_3002 9075603 71.4286 µM -0.551243042035218 0.270687003902239 no 2463 0.290733538960107 3456 20105405 SGTC_3057 9095946 49.47 µM -0.551934055269378 0.270436223382968 no 2464 0.290496767478058 3435 24540043 SGTC_205 1486-1330 71.903 µM -0.552775536572056 0.270130992295221 no 2465 0.290208560951181 3427 4118834 SGTC_1304 1165-0502 251 µM -0.553964184708529 0.269700126981074 no 2466 0.289801678532874 3371 767425 SGTC_2651 TUB2.036 5 µM -0.554869747484938 0.269372106609189 no 2467 0.289491877903417 3531 15992207 YFL037W TUB2 SGTC_1329 1447-1697 50.6 µM -0.555089640032703 0.269292485521615 no 2468 0.289416674292829 3442 2840515 SGTC_1195 1502-0147 41.1 µM -0.556581651008742 0.268752553867224 no 2469 0.288906646659314 3448 817940 SGTC_2284 7945075 39.21 µM -0.556604843008251 0.268744165398326 no 2470 0.288898722067471 3453 1245402 SGTC_1279 0874-0590 65.2 µM -0.557013284123619 0.268596455167498 no 2471 0.28875917652032 3402 3523074 SGTC_750 4073-0104 132 µM -0.557221298245303 0.268521243817596 no 2472 0.288688119859564 3367 22330957 SGTC_373 0844-0104 25.9 µM -0.55774385252568 0.268332351375444 no 2473 0.288509654072747 3455 5375804 SGTC_1096 rimcazole 32.2 µM -0.558271725148856 0.268141604346285 no 2474 0.288329424737756 3344 18528119 A dopamine reuptake inhibitor. SGTC_2809 7964133 12.99 µM -0.558305235831956 0.268129497548626 no 2475 0.288317985118089 3389 1253665 SGTC_1010 4112-3296 15.2 µM -0.558802269477358 0.26794996068003 no 2476 0.288148336722636 3511 704384 SGTC_1359 1582-0056 520 nM -0.559320308652021 0.267762900713795 no 2477 0.287971568824373 3468 3661189 SGTC_1661 st013063 9.66 µM -0.559531979262684 0.267686487022156 no 2478 0.287899356263553 3452 721395 SGTC_918 glabranin 770.725 nM -0.560645240923076 0.267284777386903 no 2479 0.287519701917122 3423 124049 Also referred to as licorice root. SGTC_1112 tnp00069 1.16933 µM -0.560941614572707 0.26717788513262 no 2480 0.287418669864613 3456 145826 SGTC_1849 st056239 19.2 µM -0.563061778337283 0.266413841437932 no 2481 0.286696408555515 3352 5393181 SGTC_3083 9117465 49.47 µM -0.563459438714737 0.266270659723653 no 2482 0.286561036287567 3437 16420915 SGTC_1819 st053448 58.6 µM -0.563859201860274 0.266126760154895 no 2483 0.286424978761356 3380 2857616 SGTC_1722 st034304 3.6505 µM -0.563957217684844 0.266091484188063 no 2484 0.28639162421209 3381 4036148 YLR033W RSC58 SGTC_560 2332-1943 155 µM -0.564071726003753 0.266050275559883 no 2485 0.286352659641814 3463 21177716 SGTC_18 0111-0177 500 nM -0.565338484520344 0.265594617195615 no 2486 0.285921778594019 3506 721752 SGTC_2508 celastrol 40.54 µM -0.566077363079982 0.265329022353508 no 2487 0.285670595457517 3422 122724 Celastrol is a natural product and antioxidant. SGTC_105 0111-0055 734.78 µM -0.567139753276141 0.26494737550723 no 2488 0.285309618056096 3438 5179370 SGTC_114 0364-0001 490.298 µM -0.568237060320817 0.264553478414568 no 2489 0.284937004930283 3456 4003655 SGTC_2855 9016525 58.44 µM -0.570124329748726 0.263876708425141 no 2490 0.284296687299761 3470 43811474 SGTC_969 1313-0238 134 µM -0.570251884395379 0.263830999518061 no 2491 0.284253435056403 3401 5212874 SGTC_2576 guaiol 23.12 µM -0.573771836448677 0.262571227845546 no 2492 0.283061104665847 3419 227829 SGTC_3334 9142812 21.919 µM -0.573831402959066 0.262549935835647 no 2493 0.283040948085015 3481 45283678 SGTC_2888 9058547 12.99 µM -0.574135334666821 0.262441309406407 no 2494 0.282938112027969 3407 16476514 SGTC_325 2810-4341 181 µM -0.574157689903492 0.262433320462417 no 2495 0.282930548785815 3497 774970 SGTC_1616 st002734 56.1 µM -0.574382751526994 0.262352898606688 no 2496 0.282854411159963 3380 4026101 SGTC_668 1682-0499 62.6 µM -0.575632200883533 0.26190665925832 no 2497 0.282431905500079 3451 682214 SGTC_1090 efavirenz 20.7 µM -0.576242677725968 0.261688769812961 no 2498 0.282225581066514 3479 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2235 salicylic acid 500 µM -0.577258342670481 0.261326468142467 no 2499 0.281882474991029 3463 338 A COX inhibitor and kinase inhibitor. SGTC_1081 sertraline 6 µM -0.578980160770028 0.260712861100594 no 2500 0.281301279893772 3492 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2370 9071495 200 µM -0.579579217140151 0.26049954842134 no 2501 0.281099205749969 3438 21791103 SGTC_2807 7945238 51.95 µM -0.579731032743542 0.260445504024357 no 2502 0.281048006336155 3475 17148797 SGTC_1152 3909-8331 15.9 µM -0.582228708692319 0.259557193313722 no 2503 0.280206319137226 3445 16001939 SGTC_58 0957-0393 9 µM -0.582808444217797 0.259351231459221 no 2504 0.280011129902873 3480 6997992 SGTC_752 1896-0090 130 µM -0.583868696790252 0.258974775510946 no 2505 0.279654327574426 3497 772567 SGTC_2962 9082311 13.18 µM -0.585920787244152 0.258246958828109 no 2506 0.278964373726765 3431 16459453 SGTC_2941 9056145 11.23 µM -0.586648394731337 0.257989152493236 no 2507 0.27871993653822 3460 2119517 SGTC_3108 9121785 49.47 µM -0.588746719015869 0.257246421263704 no 2508 0.278015596334784 3477 17140271 SGTC_944 3370-0224 231 µM -0.589772524345087 0.256883728062444 no 2509 0.277671582712096 3454 4580514 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.590218010736592 0.256726300696537 no 2510 0.277522249377318 3450 688664 SGTC_636 0kpi-0074 126 µM -0.590384343080243 0.256667534536196 no 2511 0.277466502489584 3475 616434 SGTC_1078 idebenone 36.1 µM -0.591532763506286 0.256261982299567 no 2512 0.277081754649152 3498 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2264 7948757 110.76 µM -0.591842544660445 0.256152643675888 no 2513 0.276978015411729 3453 2971411 SGTC_3145 9085516 49.47 µM -0.592551832322869 0.255902389117475 no 2514 0.2767405614232 3479 25236195 SGTC_1759 st043059 70 µM -0.594065007868652 0.25536892940638 no 2515 0.27623431695248 3421 669426 SGTC_2458 5808907 16.39 µM -0.594533724892949 0.255203804398248 no 2516 0.276077596318477 3590 2731747 SGTC_2047 4141938 200 µM -0.594748593089272 0.255128126833473 no 2517 0.276005767396259 3456 3807862 SGTC_3060 1327-0027 12.5 µM -0.595995681638438 0.25468912837668 no 2518 0.275589055791637 3443 16000455 YPR107C YTH1 SGTC_2782 7736369 71.43 µM -0.596424713306278 0.254538192720617 no 2519 0.275445767461336 3491 2950836 YOL077C BRX1 SGTC_3286 9117135 37.221 µM -0.596688804521547 0.254445307311813 no 2520 0.275357584299361 3414 3438150 SGTC_1523 st012844 44.7 µM -0.59825782454691 0.253893822524034 no 2521 0.274833956703971 3510 4274103 SGTC_956 1185-0240 191 µM -0.598654275925983 0.253754575720514 no 2522 0.2747017270718 3493 1416193 SGTC_121 0557-0495 61.343 µM -0.599382030546249 0.253499068689269 no 2523 0.274459078543675 3567 3104427 SGTC_346 4513-0042 7.16 µM -0.599825285822264 0.253343512667368 no 2524 0.274311339863888 3519 2827372 SGTC_1419 3993-2473 62.6 µM -0.601043666456788 0.252916192779944 no 2525 0.273905451338276 3513 704026 SGTC_2335 9018011 154.17 µM -0.601107787451147 0.252893714280557 no 2526 0.273884098444138 3499 6458208 SGTC_3245 9134821 49.47 µM -0.601279802170554 0.252833417341618 no 2527 0.273826819990391 3442 17014901 SGTC_1358 1509-0022 2.48 µM -0.601626217820317 0.252712009988178 no 2528 0.273711486487568 3519 3258434 SGTC_2759 disulfiram 3.38 µM -0.602858273444041 0.252280463681164 no 2529 0.273301488251475 3469 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1168 k815-0004 80.5 µM -0.604139638174641 0.251832058631176 no 2530 0.272875404079657 3484 642433 SGTC_2977 9011197 71.43 µM -0.605207492390223 0.251458691839759 no 2531 0.27252056908263 3563 2704722 SGTC_1307 1187-1599 12.2 µM -0.605451648914429 0.251373365547965 no 2532 0.272439471023182 3427 1538471 SGTC_1637 st007924 17.4 µM -0.605902206260788 0.251215947779738 no 2533 0.272289847161656 3527 683336 SGTC_1337 1486-1011 40.3 µM -0.608533894920628 0.250297518994383 no 2534 0.271416716338554 3555 X1337 SGTC_1784 st039334 36.3 µM -0.608877938777202 0.250177583398952 no 2535 0.27130267407001 3611 3496984 SGTC_890 0929-0006 47.2 µM -0.609032039190419 0.250123873026093 no 2536 0.271251601232481 3461 1378169 SGTC_200 k038-0079 37.545 µM -0.609744822168253 0.249875518252227 no 2537 0.271015429004385 3462 3436683 SGTC_2816 7982706 58.44 µM -0.610087163612867 0.249756282867003 no 2538 0.270902034682371 3488 2981853 SGTC_3143 9086658 49.47 µM -0.611541598913288 0.249250049161929 no 2539 0.270420543796735 3530 25236626 SGTC_3036 9090181 49.47 µM -0.612355641340062 0.248966950231738 no 2540 0.270151241809601 3549 25236586 SGTC_2229 7354935 190 µM -0.612676244376105 0.248855501336493 no 2541 0.270045216558466 3497 318112 SGTC_1194 1488-0194 225 µM -0.614806979777403 0.248115484590326 no 2542 0.26934109963726 3515 1391452 SGTC_3074 9116018 49.47 µM -0.61622287189176 0.247624386995204 no 2543 0.268873717509467 3550 17027303 SGTC_907 3448-6986 75.5 µM -0.61628117414417 0.247604176183424 no 2544 0.26885448082864 3595 590582 SGTC_207 4185-0010 4.486 µM -0.616548978056684 0.247511351734467 no 2545 0.268766128484141 3598 3761753 SGTC_738 1315-0003 72.4 µM -0.618122540602434 0.246966309525151 no 2546 0.268247282466726 3551 6251474 SGTC_870 0573-2213 57.6 µM -0.618231524293637 0.24692858413073 no 2547 0.268211366272235 3559 3916321 SGTC_280 3448-3607 3.04 µM -0.619035303006006 0.246650446316321 no 2548 0.267946551185144 3542 626179 SGTC_2403 6032726 181.2 µM -0.619516543187591 0.246483999362459 no 2549 0.267788063545038 3521 2881040 SGTC_629 3448-6466 76.7 µM -0.619643651397313 0.246440046386696 no 2550 0.267746210670275 3557 573744 SGTC_1982 st072467 71.9 µM -0.619970579526476 0.246327016619312 no 2551 0.267638578305313 3485 3163533 SGTC_778 3456-2434 196 µM -0.620500337415204 0.24614392097192 no 2552 0.267464215967354 3543 5539063 SGTC_2587 piperic acid 92.2 µM -0.621359254494785 0.245847216048533 no 2553 0.267181637314747 3474 5370536 SGTC_1131 3454-3128 32.3 µM -0.621867090711687 0.245671879093635 no 2554 0.267014633111717 3529 710982 SGTC_1298 1079-1278 263 µM -0.621882824978977 0.245666447709161 no 2555 0.267009459669883 3561 2840950 SGTC_795 0685-0265 78 µM -0.622228286876428 0.245547212371902 no 2556 0.266895884232669 3621 302754 SGTC_1225 1216-0074 20.6 µM -0.623831264618625 0.244994355515938 no 2557 0.266369202407989 3514 4241466 SGTC_667 1498-1044 59 µM -0.625052255922594 0.244573693104903 no 2558 0.265968380974567 3546 6739982 SGTC_3335 9143315 29.6265 µM -0.625212323432787 0.244518574653998 no 2559 0.265915857408765 3489 4899691 SGTC_2663 amphotericin b 100 µM -0.625257627372412 0.24450297568281 no 2560 0.265900992607669 3536 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2539 epi(13)torulosol 80 µM -0.626221505539335 0.244171221955722 no 2561 0.265584831681341 3525 6708597 SGTC_2929 9013348 24.6 µM -0.626760925162432 0.243985667052924 no 2562 0.265407980317494 3545 2995952 SGTC_2159 5658611 73.75 µM -0.627229315272984 0.24382460731124 no 2563 0.265254464817497 3583 793844 SGTC_1675 st018485 24.5 µM -0.627433475714799 0.243754423046737 no 2564 0.265187565063492 3518 3323024 SGTC_820 1582-0060 59.9 µM -0.630014257168867 0.242868168410332 no 2565 0.264342628146528 3512 3848840 SGTC_2567 aureobasidin a 60 nM -0.630355125159801 0.242751242950353 no 2566 0.264231131962054 3619 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.630362881860794 0.24274858258042 no 2567 0.26422859506337 3538 15053 SGTC_1053 3366-3204 134 µM -0.630374441791119 0.242744617819635 no 2568 0.264224814307415 3513 3632071 YPR165W RHO1 SGTC_868 0527-0199 213 µM -0.632236396768406 0.242106472560272 no 2569 0.263616208736247 3498 2849450 SGTC_1500 4488-1866 171 µM -0.634667860849828 0.241274511602689 no 2570 0.262822529514241 3632 2900003 SGTC_1944 st076371 56.9 µM -0.634751131735693 0.241246046793225 no 2571 0.262795369865411 3498 24208455 SGTC_1300 1094-0077 113 µM -0.636552229986871 0.240630817277692 no 2572 0.262208274802401 3543 5532636 SGTC_3109 9122853 49.47 µM -0.63657034314919 0.240624634420255 no 2573 0.262202373959502 3580 1234709 SGTC_1973 st070275 50.2 µM -0.637222228364145 0.240402173514178 no 2574 0.26199005036234 3534 17118334 SGTC_54 0159-0055 9 µM -0.638045929418569 0.240121239397116 no 2575 0.261721891250083 3646 3319099 SGTC_203 k066-0004 30.888 µM -0.638701135294235 0.239897900637728 no 2576 0.261508687011467 3639 6795412 SGTC_1822 st052468 42 µM -0.640424806782964 0.239310897547289 no 2577 0.260948229812163 3537 2873678 SGTC_2082 5219693 150 µM -0.640615936869911 0.239245855806814 no 2578 0.260886121329761 3587 2834649 SGTC_2792 7535235 81.82 µM -0.643102574874304 0.238400531536756 no 2579 0.260078771925685 3527 1281891 SGTC_953 1188-0045 9.7 µM -0.643408832889407 0.23829653339016 no 2580 0.259979426746179 3571 6144426 SGTC_645 0845-0943 5.41 µM -0.64353225496171 0.238254629131982 no 2581 0.259939396142267 3555 1885106 SGTC_475 α-linolenic acid 10 µM -0.644639516894889 0.237878872207681 no 2582 0.259580410051723 3683 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2617 dihydrotanshinone i 20.83 µM -0.650307630727809 0.235960457834201 no 2583 0.257746764518336 3617 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3156 9099931 49.47 µM -0.650559753252691 0.23587532365541 no 2584 0.257665358870802 3598 18111053 SGTC_2224 6650123 117.647 µM -0.650592268510945 0.23586434546533 no 2585 0.257654861273972 3570 2908370 SGTC_1843 st055809 45.5 µM -0.652077899820479 0.235363049415651 no 2586 0.257175460084542 3591 16413835 SGTC_2904 7225135 42.03 µM -0.652928718111893 0.235076223152164 no 2587 0.256901116920152 3671 4446116 SGTC_1319 1306-0155 43.7 µM -0.654276461513988 0.234622269862828 no 2588 0.256466853994751 3629 3122360 SGTC_911 3456-4043 236 µM -0.654721268772054 0.234472554259352 no 2589 0.256323614482466 3657 914281 SGTC_1581 himbacine 57.9 µM -0.656051384804926 0.234025172198659 no 2590 0.255895531412163 3609 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2968 9090663 33.37 µM -0.656264138447089 0.233953656793478 no 2591 0.255827093643313 3563 25236811 SGTC_2091 4-phenylthiadiazole 200 µM -0.656337743667499 0.233928917816908 no 2592 0.255803418825191 3600 270010 SGTC_225 nsc-122657 1.016 µM -0.65686177741638 0.233752830106037 no 2593 0.255634898574279 3557 275685 SGTC_2817 7995342 71.43 µM -0.657851067113586 0.233420605771291 no 2594 0.255316918119243 3555 18879975 SGTC_2723 salbutamol 83.58 µM -0.658139527464303 0.233323784052745 no 2595 0.255224239277401 3587 9884233 β2-adrenoceptor agonist SGTC_2464 5717415 7.67 µM -0.658325189152878 0.233261478495435 no 2596 0.255164597715037 3520 5285744 SGTC_1911 st060208 74.3 µM -0.658739292773547 0.233122544179651 no 2597 0.255031598218799 3611 688783 SGTC_1264 0783-0040 158 µM -0.659431555084802 0.232890388541082 no 2598 0.254809342278113 3569 2855798 SGTC_2720 fluspirilene 36.88 µM -0.659677661642458 0.232807885717521 no 2599 0.254730352383498 3580 3396 An atypical antipsychotic. SGTC_2401 5128683 200 µM -0.659932643506074 0.232722424737767 no 2600 0.254648527412566 3563 708373 SGTC_3173 9105693 49.47 µM -0.664373445926999 0.231236822723462 no 2601 0.253225661958687 3667 17096658 SGTC_1019 4262-0212 3.4 µM -0.664595273944348 0.231162752577955 no 2602 0.253154696439178 3661 4677213 SGTC_1914 st062367 72.6 µM -0.664768002375718 0.231105086345065 no 2603 0.253099445727227 3605 978205 SGTC_933 2914-0560 114 µM -0.665339702465951 0.230914278740575 no 2604 0.252916621043361 3647 463887 SGTC_3193 9111931 49.47 µM -0.665698963270033 0.23079441876972 no 2605 0.252801768155771 3654 17087244 SGTC_1530 rhein 70.4 µM -0.666019832707579 0.230687396670969 no 2606 0.252699211908777 3655 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2681 menadione 3.18 µM -0.666884626461024 0.230399093334277 no 2607 0.252422915784253 3630 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2594 a-mangostin 100 µM -0.667493061049521 0.230196375318649 no 2608 0.252228620246189 3633 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2299 7976368 114.88 µM -0.668158720139245 0.229974705596538 no 2609 0.252016141193338 3617 2979718 SGTC_2154 5570129 200 µM -0.668481604897649 0.229867225471919 no 2610 0.251913110079469 3638 673366 SGTC_844 0330-0132 15.3 µM -0.670512751780312 0.229191753565505 no 2611 0.251265490137245 3629 2828079 SGTC_2357 9067248 200 µM -0.670650134368232 0.2291461062639 no 2612 0.251221718267107 3619 9150235 SGTC_1905 st060207 84.5 µM -0.671091925050228 0.228999349650313 no 2613 0.251080985377634 3571 1948547 SGTC_729 4092-0585 94.1 µM -0.67142044175358 0.228890255245032 no 2614 0.25097636307822 3614 2169061 SGTC_1609 st001574 46.4 µM -0.672067401491365 0.228675497021359 no 2615 0.250770394098701 3620 3960012 SGTC_3350 9150499 3.57 µM -0.674490759476595 0.227872070051729 no 2616 0.249999679274407 3618 4910996 YPR165W RHO1 SGTC_3158 9100007 49.47 µM -0.674666759974101 0.227813781729954 no 2617 0.249943753797423 3637 19297233 SGTC_2757 clomiphene 4.22 µM -0.674963717470016 0.227715453565778 no 2618 0.249849408382067 3690 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1240 0356-0016 42.1 µM -0.675487133568623 0.227542198911199 no 2619 0.249683161567256 3613 4305613 SGTC_606 k015-0008 38.6 µM -0.676209788796832 0.227303116650151 no 2620 0.249453729236856 3685 1970475 SGTC_1992 st073643 23.3 µM -0.676211654199722 0.227302499686045 no 2621 0.249453137144083 3631 3161292 SGTC_1632 st005650 90 µM -0.676283241594696 0.227278823555023 no 2622 0.249430415335998 3630 2759605 SGTC_2012 4023501 200 µM -0.678058065286614 0.226692279828681 no 2623 0.248867438931324 3616 3477460 SGTC_1426 4048-4480 71.7 µM -0.67992325306969 0.226076794219192 no 2624 0.248276528621401 3630 14224343 SGTC_1700 st030840 7.9285 µM -0.681180316532772 0.225662514392927 no 2625 0.247878700617611 3655 5499307 SGTC_2979 9012552 45.46 µM -0.683180898040497 0.225004086160511 no 2626 0.247246270734128 3698 17100905 SGTC_3310 9130229 44.1445 µM -0.683545771210906 0.2248841171791 no 2627 0.24713101901997 3668 7761258 SGTC_1456 k015-0012 13 µM -0.683663380613324 0.224845455361291 no 2628 0.247093876112268 3712 2989616 SGTC_2216 7189485 200 µM -0.684742338564351 0.224490944700572 no 2629 0.246753263547161 3646 731273 SGTC_1852 st056254 31.4 µM -0.684768700385284 0.224482287030671 no 2630 0.246744944620888 3607 442583 SGTC_2185 6113692 200 µM -0.684849046690401 0.224455901107702 no 2631 0.246719590887921 3642 874150 SGTC_2596 sinensetin 100 µM -0.684952274588869 0.224422003396969 no 2632 0.246687018785776 3649 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2729 fluphenazine 10.66 µM -0.685280249780915 0.224314323032433 no 2633 0.246583546139604 3599 3372 An atypical antipsychotic. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.685951065251417 0.224094173189369 no 2634 0.246371983497585 3655 1609 A potent and irreversible inhibitor of serine proteases. SGTC_144 4161-2749 112.381 µM -0.686274031260154 0.22398822520568 no 2635 0.246270160770487 3575 797501 YMR168C CEP3 SGTC_1489 4065-0444 182 µM -0.687558614124639 0.223567103658664 no 2636 0.245865388854185 3635 2877968 SGTC_1158 4092-0494 91.8 µM -0.688646107425517 0.22321094572758 no 2637 0.245522999136315 3737 1148199 SGTC_3246 9135460 32.98 µM -0.688832240676427 0.223150018812272 no 2638 0.245464422058233 3589 41446951 SGTC_309 k408-0051 1.48 µM -0.689200523640636 0.223029496815778 no 2639 0.245348543672353 3646 3640463 SGTC_2937 9044753 11.33 µM -0.689385790063497 0.222968881694031 no 2640 0.245290261640132 3675 6465530 YGL099W LSG1 SGTC_1031 k035-0009 16 µM -0.690104783461917 0.22273373166813 no 2641 0.245064147627834 3677 5180959 SGTC_2884 9058502 51.95 µM -0.691097527686859 0.222409282621991 no 2642 0.244752126931492 3647 6471554 SGTC_3163 9099914 49.47 µM -0.691831602598881 0.222169545438319 no 2643 0.244521543924195 3668 16268368 SGTC_2935 9038016 29.96 µM -0.692279450289904 0.222023357972868 no 2644 0.244380926312037 3660 6463195 SGTC_2826 7992541 19.48 µM -0.692326394297202 0.222008037583438 no 2645 0.244366189105455 3712 2985066 SGTC_909 3448-9333 149 µM -0.692413304623802 0.221979675597815 no 2646 0.244338906473141 3624 3344074 SGTC_1130 3454-2858 15.9 µM -0.694199844360774 0.221397121545873 no 2647 0.243778445105822 3673 715628 YIL048W NEO1 SGTC_1569 carminic acid 40.6 µM -0.695603449253605 0.220940048546857 no 2648 0.243338602739396 3687 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1385 3091-4834 14.1 µM -0.697913359632843 0.220189021406056 no 2649 0.242615689494869 3640 4072814 SGTC_3355 9151058 44.0485 µM -0.698205915913853 0.220094006391775 no 2650 0.242524213654486 3682 17015728 SGTC_1781 st038725 66.3 µM -0.698250425045487 0.220079552992726 no 2651 0.242510298276603 3692 4270275 YIL048W NEO1 SGTC_653 0203-0016 55.2 µM -0.699637081446138 0.219629538442376 no 2652 0.242076989362164 3706 295302 SGTC_1526 st051518 75 µM -0.701574272493265 0.219001743346251 no 2653 0.2414723504026 3671 673993 SGTC_3266 9136860 49.47 µM -0.702508907914065 0.218699220896479 no 2654 0.241180924208537 3618 4871271 YPR165W RHO1 SGTC_1548 st061468 90.8 µM -0.70384381645367 0.218267555561938 no 2655 0.240765021653585 3677 390799 SGTC_1390 3413-2614 145 µM -0.704146901324274 0.21816961634992 no 2656 0.24067064727722 3714 3421432 SGTC_167 3672-0051 66.205 µM -0.70527329127812 0.217805855375068 no 2657 0.240320089215471 3640 3237971 SGTC_1071 trifluoperazine 6.31 µM -0.706052608944175 0.217554384228416 no 2658 0.240077710824458 3747 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_94 0334-0113 514.748 µM -0.706495328720506 0.217411601556154 no 2659 0.239940078334845 3651 6795178 SGTC_2878 9043973 25.97 µM -0.706873047802401 0.217289825204696 no 2660 0.239822687252775 3737 6465167 SGTC_2682 pyrogallin 40.03 µM -0.707145189390287 0.217202111379465 no 2661 0.239738127958732 3723 822798 An ATP competetive kinase inhibitor. SGTC_2939 9044578 71.43 µM -0.707254060326296 0.217167026968717 no 2662 0.239704304354149 3682 2653634 SGTC_1963 st076565 50.3 µM -0.707354794302375 0.217134567665675 no 2663 0.239673011028651 3701 4914280 SGTC_3250 9135583 49.47 µM -0.707991616441025 0.216929430651853 no 2664 0.239475231844865 3709 7699353 SGTC_3304 9125678 46.087 µM -0.708748486488778 0.216685768827583 no 2665 0.239240285078761 3687 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2700 st077718 96.8 µM -0.710625119051959 0.216082301206087 no 2666 0.238658286517961 3691 904970 SGTC_3138 9097216 49.47 µM -0.711738741099041 0.215724655122465 no 2667 0.238313286434194 3703 25237486 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.713023643966791 0.215312427917277 no 2668 0.23791556320619 3692 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_936 3005-4620 401 µM -0.713343548063207 0.215209866236523 no 2669 0.237816598102892 3705 777207 SGTC_1461 k072-0203 53.8 µM -0.714769880967682 0.214752927196325 no 2670 0.237375624526332 3639 5418714 SGTC_1186 1319-0216 26 µM -0.716079340555522 0.214333926372635 no 2671 0.236971179813135 3758 4565136 SGTC_2206 7254556 146.969 µM -0.716965036115714 0.21405079131475 no 2672 0.236697835366896 3699 4398905 SGTC_2572 astragaloside iv 100 µM -0.719959880615089 0.213095027261963 no 2673 0.235774848760846 3715 45006101 An anti-inflammatory agent. SGTC_2383 9036125 200 µM -0.723153151859754 0.212078685552574 no 2674 0.234792898654405 3660 79580 SGTC_1607 st000305 50.6 µM -0.723707379880565 0.211902577171659 no 2675 0.234622700737343 3705 5457690 SGTC_2287 7945887 168.79 µM -0.72446288493355 0.211662649975577 no 2676 0.234390802582867 3745 1245853 SGTC_1163 k060-0048 49.9 µM -0.724655208800616 0.211601598714493 no 2677 0.234331790080944 3732 6809982 SGTC_3153 9100258 49.47 µM -0.725040614072556 0.211479286751614 no 2678 0.234213557388621 3675 25236848 SGTC_644 1498-1197 63.3 µM -0.726805158973148 0.210919820871521 no 2679 0.233672661143866 3764 6741615 SGTC_2620 irigenin 100 µM -0.727404935037268 0.210729853917875 no 2680 0.233488966112535 3733 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3340 9146634 11.102 µM -0.728766124113094 0.210299097315376 no 2681 0.233072368383124 3739 4907387 SGTC_2298 7976326 193.81 µM -0.72950155468725 0.210066581111826 no 2682 0.232847458563266 3613 2235818 SGTC_2388 9080168 200 µM -0.73073766410548 0.209676109063035 no 2683 0.232469702642337 3696 15943073 SGTC_2517 totarol 10 µM -0.730747526995643 0.209672995212384 no 2684 0.232466689907222 3704 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2669 eugenol 100 µM -0.731883135219617 0.209314649862874 no 2685 0.232119950312207 3693 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2321 7390090 138.78 µM -0.732032345497793 0.209267592817211 no 2686 0.232074412775268 3714 649046 SGTC_1800 st050079 29.0735 µM -0.732999923723841 0.208962594927968 no 2687 0.231779237958388 3668 3645560 SGTC_3140 9094243 49.47 µM -0.734019399991637 0.208641521302101 no 2688 0.231468457249847 3748 19291112 SGTC_2514 salinomycin 42.74 µM -0.734588755169331 0.208462335336905 no 2689 0.231294994188355 3811 23682228 A polyether potassium ionophore. SGTC_1291 0993-0025 5.79 µM -0.73587067735072 0.208059224500271 no 2690 0.230904701866258 3754 4353356 SGTC_1242 0402-0103 60.1 µM -0.736207553836491 0.207953367349135 no 2691 0.230802197947781 3696 432868 SGTC_2443 5493264 126.67 µM -0.736518515139478 0.207855681789986 no 2692 0.230707601995973 3769 5340055 SGTC_2256 7954252 200 µM -0.737025371644933 0.207696515697175 no 2693 0.230553460197136 3698 2972920 SGTC_1214 0358-0031 63.7 µM -0.737068343376693 0.207683024770366 no 2694 0.230540394569592 3812 4301366 SGTC_471 1-acyl-paf 4 µM -0.737953760959252 0.207405164164681 no 2695 0.230271273983582 3692 16759367 SGTC_2966 9084041 48.03 µM -0.740563857034728 0.206587347002747 no 2696 0.229478964676441 3697 17741380 SGTC_1519 esterone 74 µM -0.740966067976503 0.206461492956905 no 2697 0.229357007279214 3745 698 A steroid. SGTC_3006 9075424 71.4286 µM -0.742396532973205 0.206014260685317 no 2698 0.228923559773148 3736 7465181 SGTC_3038 9091290 49.47 µM -0.743045024594013 0.205811700384313 no 2699 0.228727210817121 3750 25236843 SGTC_1956 st077085 54 µM -0.743068482769228 0.205804375295996 no 2700 0.22872010997167 3786 24208685 SGTC_2552 juarezic acid 87.02 µM -0.745053367922478 0.205185132268123 no 2701 0.228119729005495 3786 1549512 SGTC_486 niguldipine 82 µM -0.746276456288211 0.204804105959676 no 2702 0.227750215332081 3760 1236 A calcium channel blocker. SGTC_3159 9100096 49.47 µM -0.746684472900286 0.204677091010795 no 2703 0.227627022260647 3715 25236875 SGTC_481 bay k-8644 50 µM -0.746920891536969 0.204603515697583 no 2704 0.227555657195891 3730 2303 A calcium channel antagonist. SGTC_2208 7283366 200 µM -0.74965198504188 0.203754719664902 no 2705 0.226732166383813 3731 898663 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.750153482051045 0.203599087936031 no 2706 0.226581135846395 3817 688664 SGTC_2777 climbazole 1.536 µM -0.752054209754922 0.203009870755409 no 2707 0.226009229640978 3705 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.753315324381397 0.20261949334598 no 2708 0.225630226121271 3759 689007 SGTC_597 k018-0003 82.8 µM -0.758815547125628 0.200922154820342 no 2709 0.223981452015409 3857 6786234 SGTC_707 0865-0008 204 µM -0.758969726693121 0.200874699101278 no 2710 0.223935333228367 3757 723043 SGTC_1241 0364-0022 50.8 µM -0.759459846620097 0.20072388725706 no 2711 0.223788762510691 3794 4563895 SGTC_1689 st020265 53.493 µM -0.760398295230435 0.200435312621742 no 2712 0.223508271002081 3761 5758320 YPR016C TIF6 SGTC_3330 9141424 71.43 µM -0.762763798979387 0.199709022522735 no 2713 0.222802137156052 3838 27261020 SGTC_679 0422-0091 41.4 µM -0.763469381042571 0.199492691790059 no 2714 0.222591758069613 3777 627384 YHR062C RPP1 SGTC_1991 st073000 8.92 µM -0.765304457450116 0.198930720110792 no 2715 0.222045135192599 3823 4301969 YIL048W NEO1 SGTC_3120 9124077 49.47 µM -0.765508805600135 0.198868199861797 no 2716 0.221984312499126 3821 18774327 YGL155W CDC43 SGTC_875 0709-0210 25.7 µM -0.766770351469127 0.198482492642578 no 2717 0.221609033539932 3769 6251364 SGTC_327 1273-0057 3.96 µM -0.767540192085193 0.198247342131496 no 2718 0.221380203086246 3699 3108138 SGTC_535 2293-4129 48.2 µM -0.767550922455843 0.198244065690951 no 2719 0.2213770145037 3781 396118 YIL048W NEO1 SGTC_2626 ethyl orsellinate 100 µM -0.771151442850516 0.197146519335022 no 2720 0.2203085858573 3800 75653 A natural product. SGTC_1027 k015-0025 8.67 µM -0.771266882017875 0.197111390962659 no 2721 0.220274379093989 3773 3598955 SGTC_2366 9070441 60.58 µM -0.772456968829018 0.196749465985475 no 2722 0.219921911896566 3789 6837235 SGTC_2911 7942208 15.64 µM -0.772871420699645 0.196623518899522 no 2723 0.219799239993268 3794 1243384 SGTC_1959 st077091 55.8 µM -0.773965330037395 0.196291327281461 no 2724 0.219475646990334 3796 821356 YKL052C ASK1 SGTC_3046 9092212 49.47 µM -0.775293819590896 0.195888357621702 no 2725 0.219083030277686 3810 25236637 SGTC_427 1354-0053 47.3 µM -0.776442179648263 0.195540431306992 no 2726 0.218743974023545 3915 6813657 SGTC_1709 st033179 39.1045 µM -0.779536096503522 0.194604915855054 no 2727 0.217831991417338 3778 573381 SGTC_2173 5763948 167 µM -0.7804024482607 0.194343443779017 no 2728 0.21757701362976 3807 2867177 SGTC_3167 9103034 49.47 µM -0.780664877114362 0.194264282825169 no 2729 0.217499811651795 3823 5127859 SGTC_2181 6316240 54.2555 µM -0.782759670819848 0.193633098160365 no 2730 0.216884127116936 3815 12779990 SGTC_3180 9109287 49.47 µM -0.782960697954402 0.193572592282236 no 2731 0.216825095904478 3839 18891271 SGTC_2714 st079313 56.9 µM -0.783125289961423 0.193523061367887 no 2732 0.216776770711027 3787 2939799 SGTC_646 4092-0839 27.3 µM -0.783400836126936 0.193440158161647 no 2733 0.216695882658022 3839 877796 SGTC_1892 st058411 7.36 µM -0.78452734318262 0.193101452905443 no 2734 0.216365372093945 3786 3934738 SGTC_1669 st015249 58.4 µM -0.786259844461889 0.192581251395353 no 2735 0.215857636240036 3879 722793 SGTC_2696 st077691 74.316 µM -0.787783372374936 0.192124504849631 no 2736 0.215411714331446 3817 757133 SGTC_2371 9071574 200 µM -0.787792777324954 0.19212168734951 no 2737 0.21540896325412 3777 45596039 SGTC_1120 ficusin 1.78878 µM -0.787837624710747 0.192108252483337 no 2738 0.215395845056857 3925 6199 A DNA cross-linker. SGTC_226 1,3-diallylurea 8.28947 mM -0.789395927097664 0.191641791160658 no 2739 0.214940317818775 3779 74537 YKL182W FAS1 SGTC_2212 7123476 200 µM -0.789900247704727 0.191490976833221 no 2740 0.214793013358563 3765 1085715 SGTC_2725 haloperidol 53.21 µM -0.797145244733105 0.189332433533876 no 2741 0.212683341014834 3788 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1063 disulfiram 1.84 µM -0.797448046303758 0.189242545416969 no 2742 0.212595432365146 3810 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_411 enrofloxacin 100 µM -0.797751530723449 0.189152480961289 no 2743 0.212507346768771 3886 71188 A bacterial gyrase inhibitor. SGTC_2226 7298446 200 µM -0.797912753077323 0.189104646067832 no 2744 0.21246056105499 3799 3283010 SGTC_1704 st028805 70.8 µM -0.800989738527082 0.188193128734618 no 2745 0.211568793220181 3856 2876101 SGTC_548 1436-0017 110 µM -0.801618243041482 0.188007276363186 no 2746 0.211386910764795 3892 9677137 SGTC_1065 prochlorperazine maleate 2.48 µM -0.805254784361339 0.186934156169172 no 2747 0.210336334120176 3881 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3030 9087619 49.47 µM -0.80582558050982 0.186766062646789 no 2748 0.21017171307982 3875 25236973 SGTC_3169 9102970 49.47 µM -0.805930604535967 0.186735144358646 no 2749 0.210141431764656 3905 17027839 SGTC_2655 perillic acid 100 µM -0.806740312799936 0.186496878689565 no 2750 0.209908056663307 3873 5702197 An apoptosis inducer. SGTC_1441 4106-0040 13 µM -0.80873284061059 0.18591135742848 no 2751 0.209334416911692 3821 2904180 SGTC_730 1436-0052 41.2 µM -0.80876228533014 0.185902713402997 no 2752 0.209325946833433 3861 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_385 1494-0393 12.4 µM -0.808983028747793 0.185837918152217 no 2753 0.209262454129577 3846 3090647 SGTC_1846 st056244 14.8 µM -0.809322782304723 0.185738216993984 no 2754 0.209164752545256 3877 5393182 SGTC_2487 5918373 44.05 µM -0.809492241551173 0.185688501344836 no 2755 0.209116031860892 3855 2876279 SGTC_590 k048-0076 22.4 µM -0.810051414009065 0.185524510908933 no 2756 0.208955313392179 3832 6832814 SGTC_170 4197-0004 226 µM -0.814909904410306 0.184103430542096 no 2757 0.207561941690817 3894 218692 SGTC_209 4077-0173 175.592 µM -0.814976145184689 0.184084102439165 no 2758 0.207542982447237 3811 15993494 SGTC_2610 ononetin 44.17 µM -0.815709343283685 0.183870250185177 no 2759 0.207333196966731 3868 259632 SGTC_2726 cimetidine 79.27 µM -0.81822110201955 0.183138817896319 no 2760 0.206615473916878 3846 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2677 mitomycin C 100 µM -0.819207733469988 0.182852004790012 no 2761 0.206333951699228 3875 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1062 mesoridazine 14.2 µM -0.823091207776374 0.181725807090491 no 2762 0.205228064145812 3872 4078 A neuroleptic. SGTC_1469 k284-2957 126 µM -0.826085365458162 0.180860478406242 no 2763 0.204377834354601 3849 23884841 SGTC_3331 9141060 1.957 µM -0.826893035509016 0.180627500161879 no 2764 0.204148845603357 3851 4906567 YPR165W RHO1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.832724452228556 0.178950975257203 no 2765 0.202500075322439 3878 6857784 SGTC_1325 1431-0015 227 µM -0.834013737307452 0.178581633494867 no 2766 0.202136621387356 3844 1103340 SGTC_839 0122-0028 230 µM -0.834175126192245 0.178535434220105 no 2767 0.202091152804901 3869 759448 SGTC_399 oxolinic acid 75 µM -0.836855366275564 0.177769288029157 no 2768 0.20133693577406 3850 4628 A DNA gyrase inhibitor. SGTC_1923 st058458 19.1 µM -0.838924841916937 0.177179149935055 no 2769 0.200755743265979 3890 3534982 SGTC_352 k048-0007 5.11 µM -0.839669115349624 0.176967213497971 no 2770 0.200546967614991 3901 6811911 SGTC_216 k038-0035 28.382 µM -0.841047290064967 0.17657519292938 no 2771 0.200160721132355 3799 4444231 YPR107C YTH1 SGTC_967 1306-0166 352 µM -0.84256456401324 0.176144241370566 no 2772 0.199736008246456 3836 4437607 SGTC_3222 9128301 49.47 µM -0.842789119854594 0.176080517343881 no 2773 0.199673197024629 3915 4911358 SGTC_781 4335-2806 94.4 µM -0.842921727813061 0.176042892966226 no 2774 0.199636110416841 4006 845254 SGTC_818 4072-2707 53.5 µM -0.843303966929202 0.175934470124276 no 2775 0.199529232395192 3806 882871 SGTC_2066 5222451 176 µM -0.843979375543207 0.175742992603195 no 2776 0.199340465350247 3873 2281147 SGTC_1769 st044406 64.4 µM -0.845907877613919 0.175196991586638 no 2777 0.198802068780126 3889 670903 SGTC_675 1309-0189 238 µM -0.847768615177986 0.17467119714235 no 2778 0.198283422481066 3923 4246530 SGTC_3122 9126309 49.47 µM -0.847961726826401 0.174616686421471 no 2779 0.198229642983785 3932 17591206 SGTC_2785 7756463 72.73 µM -0.848068952423222 0.174586423908336 no 2780 0.198199785621415 3866 2201551 SGTC_1371 2421-0008 32.7 µM -0.849152542097793 0.174280786954544 no 2781 0.197898208452234 3898 2827552 SGTC_2195 6536160 144.242 µM -0.850711538662751 0.173841653734891 no 2782 0.197464805947764 3825 3834386 SGTC_1729 st035615 45.989 µM -0.851432780694508 0.173638734858726 no 2783 0.197264494314484 3954 17385451 SGTC_1714 st033236 13.627 µM -0.851500506522912 0.173619688181343 no 2784 0.197245691033709 3921 2916566 SGTC_1741 st038134 10.228 µM -0.854500013871944 0.172777463856394 no 2785 0.196414000863484 3969 1272587 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.854849484480375 0.172679506514819 no 2786 0.196317239627045 3910 676296 Flavone; oxidizing agent. SGTC_229 benomyl 22.8748 µM -0.854869406933586 0.172673923276502 no 2787 0.196311724379549 3921 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2269 7935389 174.42 µM -0.856560450184284 0.172200430392044 no 2788 0.195843925555208 3866 97605 SGTC_2772 vinpocetine 57.06 µM -0.857118364340208 0.172044396115445 no 2789 0.195689736468263 3897 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_748 act1.228 77.9 µM -0.858396968288358 0.171687143941456 no 2790 0.195336650544315 3864 4421505 YNR035C ARC35 SGTC_460 trequinsin 123 µM -0.858453759490535 0.171671287024621 no 2791 0.195320976661118 3950 5537 A vasodilator. SGTC_1208 2323-2347 50.3 µM -0.862309020855824 0.170597030746873 no 2792 0.194258744993907 3926 5412760 SGTC_1455 4262-0120 131 µM -0.864329317857198 0.170035803814892 no 2793 0.193703504557123 4026 1529587 SGTC_41 0478-0632 82.643 µM -0.866114204534639 0.169540958279209 no 2794 0.193213768154967 3841 3750424 SGTC_1527 coumarin 137 µM -0.866191986029773 0.169519415013314 no 2795 0.193192443702324 4044 323 A hepatotoxic, DNA x-linker. SGTC_1670 st016595 4.04 µM -0.868003486350383 0.169018177707855 no 2796 0.192696212040342 3926 597879 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.868241573708626 0.16895237041881 no 2797 0.192631049761222 3988 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_972 1319-0219 195 µM -0.869162253848792 0.168698049553802 no 2798 0.19237919498657 3907 23903702 SGTC_3012 9080433 71.4286 µM -0.869305719937997 0.168658441867664 no 2799 0.192339967554502 3888 17688859 SGTC_914 3820-6779 408 µM -0.870867645695917 0.168227616917243 no 2800 0.191913212236419 3884 2893481 SGTC_2240 6690706 185.951 µM -0.871537001838346 0.168043205753505 no 2801 0.191730505746189 3794 805876 SGTC_1626 st003712 1.76 µM -0.872083258861057 0.167892805493022 no 2802 0.19158147917582 3942 24207035 SGTC_3121 9125696 49.47 µM -0.872894849941728 0.167669511203476 no 2803 0.19136019682241 4001 1235365 SGTC_2984 9022109 38.96 µM -0.873149881045725 0.167599383619555 no 2804 0.191290694306296 3969 6459207 SGTC_1342 1486-1464 234 µM -0.875090015922206 0.167066510612853 no 2805 0.190762464535385 3959 3253938 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.876072225802129 0.166797156090113 no 2806 0.190495385314897 3931 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2232 chlorophetanol 41.5365 µM -0.876714360129866 0.166621213106052 no 2807 0.19032090247888 4000 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_801 0866-0028 10.1 µM -0.876725523655046 0.16661815539148 no 2808 0.190317869957773 3923 6849771 SGTC_1013 4112-3890 241 µM -0.8768865572147 0.166574051967563 no 2809 0.190274129221914 3895 705171 SGTC_516 3992-2719 87.3 µM -0.877864082920681 0.166306491660514 no 2810 0.190008741377276 3882 5350887 YDR037W KRS1 SGTC_3080 9117754 49.47 µM -0.878193684457489 0.166216338438129 no 2811 0.189919309376725 3945 9550191 SGTC_1174 0739-0097 51.1 µM -0.878761134005516 0.166061202556747 no 2812 0.189765401837461 3961 728447 SGTC_1666 st014829 29 µM -0.879130729762627 0.165960208547107 no 2813 0.189665198815255 3934 3858230 SGTC_650 1328-0195 38 µM -0.880225648997245 0.165661249064607 no 2814 0.189368540661555 3884 2780821 SGTC_1228 0124-0032 52.5 µM -0.880351053111048 0.165627030652452 no 2815 0.189334581824739 4014 X1228 SGTC_1762 st045503 25.4615 µM -0.88179100466715 0.165234445653298 no 2816 0.188944918491229 4039 4645554 SGTC_1486 3970-0793 4.53 µM -0.882423755168667 0.165062124666868 no 2817 0.188773847103708 3975 2844330 SGTC_3253 9135987 49.47 µM -0.88465687889048 0.164454894076071 no 2818 0.188170859685182 3930 4182430 SGTC_728 3030-5151 22.5 µM -0.884988451051997 0.164364856650691 no 2819 0.188081430117758 3972 3125388 SGTC_2612 dictamnine 15.46 µM -0.885707651785609 0.164169669710928 no 2820 0.187887541980777 3932 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1059 3448-6867 171 µM -0.886668097348013 0.163909244838619 no 2821 0.187628809589735 3873 3934407 SGTC_1070 indatraline 8.81 µM -0.888083431876981 0.163525965657792 no 2822 0.187247937051587 3928 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_400 oxethazaine 37.5 µM -0.889188891923401 0.163227007088063 no 2823 0.186950785821661 3976 4621 A local anesthetic. SGTC_1202 1988-0068 29.6 µM -0.889652311179792 0.163101786554306 no 2824 0.186826304070592 3913 2850480 SGTC_416 estradiol valerate 100 µM -0.889780726553609 0.163067098482299 no 2825 0.186791818746581 3981 13791 A steroid. SGTC_689 0833-0039 98 µM -0.89046631998574 0.16288198440273 no 2826 0.186607772639738 3928 5374726 SGTC_237 nikkomycin 200 µM -0.89168184703534 0.162554121289128 no 2827 0.186281743099868 3963 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2292 7671323 168.05 µM -0.893283925312478 0.162122650438602 no 2828 0.18585257203908 4012 937504 SGTC_23 0213-0011 39.996 µM -0.893502398246998 0.162063869266329 no 2829 0.185794094195924 3953 627608 SGTC_129 0088-0017 176.636 µM -0.899008154864774 0.160587102931885 no 2830 0.184324158492609 3804 182446 SGTC_1154 4088-0362 150 µM -0.899037428684358 0.16057927460806 no 2831 0.1843163623111 3956 6618304 SGTC_260 nsc-65238 3.989 µM -0.8995880460674 0.160432076470988 no 2832 0.184169760531596 3953 3246252 SGTC_176 1486-1328 72.834 µM -0.901293095076222 0.159976820174674 no 2833 0.18371625205232 4046 22310231 SGTC_301 4119-0100 24.5 µM -0.902690949849211 0.159604217084163 no 2834 0.183344970497468 3994 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3113 9123498 49.47 µM -0.902715032745098 0.159597802684651 no 2835 0.183338577987446 4029 8897275 SGTC_711 k292-0785 179 µM -0.903718646997117 0.159330643373577 no 2836 0.183072304442606 3941 4146315 SGTC_982 1491-0518 27.5 µM -0.90374421289189 0.159323841630872 no 2837 0.183065524589432 3901 3091256 SGTC_3243 9134147 49.47 µM -0.904863910192646 0.159026135468637 no 2838 0.182768744269974 4027 24282180 SGTC_2347 9049783 174.81 µM -0.905989595316787 0.158727204901239 no 2839 0.182470679806501 4030 6467988 YPL169C MEX67 SGTC_831 k061-1017 217 µM -0.906901168531882 0.15848540280052 no 2840 0.18222953158774 4019 1240153 SGTC_836 0330-0104 1.35 µM -0.907435286123565 0.158343836142425 no 2841 0.18208832833062 3963 46494820 SGTC_1485 3909-9022 254 µM -0.908254088504717 0.158126975553356 no 2842 0.181871996553239 4006 714516 SGTC_2293 7624732 200 µM -0.909732428441734 0.157735929761753 no 2843 0.181481818901751 3873 894453 SGTC_3014 9081533 49.47 µM -0.911122820841427 0.157368727724899 no 2844 0.181115331732672 4021 21367265 SGTC_1608 st001473 40.5 µM -0.911442192160749 0.157284461318455 no 2845 0.181031215631697 3965 7292267 SGTC_1213 1315-0166 115 µM -0.912842906358936 0.156915232064221 no 2846 0.180662584328919 4085 768401 SGTC_128 0906-2981 13.371 µM -0.913748673920943 0.156676774947895 no 2847 0.180424460797158 3918 6740226 SGTC_2165 5727197 32.143 µM -0.914785417129804 0.156404129400066 no 2848 0.180152145958257 4170 1361712 SGTC_1427 4048-4900 550 nM -0.915408161573747 0.156240508675914 no 2849 0.17998869767507 3976 24132586 SGTC_997 3996-0078 137 µM -0.918822955366079 0.15534530625474 no 2850 0.1790940917599 4030 735687 SGTC_971 1315-0384 26.7 µM -0.922985131095708 0.154258760707536 no 2851 0.178007476956992 4023 6769120 SGTC_528 3492-0019 172 µM -0.923675061245023 0.154079139631104 no 2852 0.177827760100985 3986 2869262 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.924160885205112 0.153952739992743 no 2853 0.177701278659348 4010 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1255 0566-0045 221 µM -0.925044583211179 0.153722999119604 no 2854 0.177471358587184 4039 2788469 SGTC_537 1334-0398 209 µM -0.925751811893998 0.153539299741906 no 2855 0.177287487551183 4027 5846986 SGTC_2273 7815444 169.05 µM -0.929039798318168 0.152687170227388 no 2856 0.176434230764768 3962 2824616 SGTC_1243 0416-0003 5.65 µM -0.92931030582362 0.152617204204938 no 2857 0.176364147910664 4013 2141977 SGTC_2097 5376186 200 µM -0.931057954456706 0.152165692366368 no 2858 0.175911793160792 3980 742755 SGTC_1906 st060206 94.7 µM -0.931439892804181 0.152067135328079 no 2859 0.175813031607861 4035 5133468 SGTC_1897 st060201 15 µM -0.934165336051566 0.15136508090016 no 2860 0.1751093067722 4050 611878 SGTC_1624 st003710 6.25 µM -0.934360404915195 0.151314915366606 no 2861 0.175059007502705 4049 24207033 SGTC_2258 7960471 200 µM -0.935069014779578 0.151132776404932 no 2862 0.174876366812176 4041 2974708 SGTC_2566 crystal violet carbinol 226 nM -0.935433333503248 0.151039189808872 no 2863 0.17478251254916 4074 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_983 1491-0821 12.2 µM -0.935707787497357 0.150968713237781 no 2864 0.174711829981299 4027 46495113 SGTC_1258 0671-0043 57.1 µM -0.93784398966678 0.150420909763531 no 2865 0.17416229537206 4043 4298767 SGTC_832 4083-0019 164 µM -0.937948203139831 0.15039421938771 no 2866 0.174135514756019 4080 1990758 SGTC_1316 1272-0050 65.9 µM -0.93969013322884 0.149948556447935 no 2867 0.173688263844459 3979 7340392 SGTC_2001 4023502 57.655 µM -0.941770841751622 0.149417374316797 no 2868 0.173154988293551 4053 108941 YCR052W RSC6 SGTC_1290 0986-0249 10.2 µM -0.94270292244281 0.149179832164726 no 2869 0.172916439069017 3906 53329 SGTC_1604 st002052 72.4 µM -0.943833966295203 0.148891922828528 no 2870 0.172627250191423 4092 6254834 YHR062C RPP1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.944759045796503 0.14865671830453 no 2871 0.172390952314747 4069 279621 SGTC_3151 9099821 49.47 µM -0.9464475874925 0.148228041759756 no 2872 0.171960171602807 4003 17174189 SGTC_932 2857-0803 154 µM -0.950300782412438 0.147252916152857 no 2873 0.170979720730438 4108 674898 SGTC_59 0330-0160 1.33 µM -0.95108224222839 0.147055678254875 no 2874 0.170781314218226 3988 4293482 SGTC_2948 9070189 9.45 µM -0.951751682840821 0.146886854578507 no 2875 0.170611465728363 3978 6473636 YDL196W YDL196W SGTC_192 3455-0609 60.9 µM -0.952138657802661 0.14678932415486 no 2876 0.170513332929146 4097 3769639 SGTC_317 4495-0002 170 µM -0.955609013726182 0.14591662227855 no 2877 0.169634902937566 4075 15991618 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.957983344076504 0.145321554329539 no 2878 0.169035578728686 4081 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1153 4055-0057 267 µM -0.95804279007437 0.145306676620496 no 2879 0.169020590947973 4088 882706 SGTC_3268 9137683 49.47 µM -0.960574056192382 0.14467412060509 no 2880 0.168383189280135 4077 1953228 SGTC_363 0455-0021 3.06 µM -0.962392967191866 0.144220726993405 no 2881 0.167926122533649 4044 4597466 SGTC_2639 lactacystin 53 µM -0.963771583898178 0.143877722819347 no 2882 0.167580228102915 4103 3870 A proteasome inhibitor. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.965069040982611 0.143555414475194 no 2883 0.167255116105213 4083 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1516 st013856 110 µM -0.965198623975304 0.14352325085101 no 2884 0.167222668022549 4091 5281404 A mutagen and neurotoxin. SGTC_1680 diphenhydramine 100 µM -0.96534392457316 0.14348719176647 no 2885 0.167186289017078 4046 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_806 3966-4455 5.86 µM -0.965422627161945 0.143467662788048 no 2886 0.167166586328917 4029 714982 SGTC_2784 7567673 72.73 µM -0.966622855977547 0.143170064650423 no 2887 0.166866302239456 4030 3471247 SGTC_1111 tnp00062 510.699 nM -0.969162478259815 0.142541737814631 no 2888 0.166232064426458 4095 676306 SGTC_709 3807-1509 243 µM -0.97005804889235 0.142320610512415 no 2889 0.166008779081671 4115 1886677 YPL242C IQG1 SGTC_2117 5521686 200 µM -0.970335204593753 0.142252224444188 no 2890 0.165939717391437 4019 803312 SGTC_2455 5377712 9.75 µM -0.972043164249809 0.14183128909261 no 2891 0.16551453765133 4053 2243908 SGTC_2286 7945697 125 µM -0.974585128336909 0.141206372409193 no 2892 0.164883046731618 4091 1245733 SGTC_1308 1187-1617 41.4 µM -0.974743371106176 0.141167531810411 no 2893 0.164843786714101 4067 2882570 SGTC_1233 0325-0408 14.2 µM -0.975872261127197 0.140890656564652 no 2894 0.164563884881795 4100 12874 SGTC_1833 st055984 71 µM -0.977009974478062 0.14061199023743 no 2895 0.164282107162562 4088 676288 SGTC_2754 granisetron 64.02 µM -0.977799239519947 0.140418891179158 no 2896 0.164086813620914 4079 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_588 3970-1144 52.9 µM -0.978292007651889 0.140298423446024 no 2897 0.163964960841706 3947 1888707 SGTC_89 0302-0250 142.109 µM -0.979600766518048 0.139978810132442 no 2898 0.163641613215661 4150 4203518 YLR208W SEC13 SGTC_1092 toremifene 6.32 µM -0.982167237311053 0.139353487154397 no 2899 0.163008732636619 4043 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1420 4'-methoxyflavone 42 µM -0.985005294648796 0.138664207823125 no 2900 0.162310735119481 4052 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3244 9134489 49.47 µM -0.98579110802111 0.138473768492943 no 2901 0.16211781504469 4087 16584271 SGTC_447 ml7 120 µM -0.986636847600687 0.138269005465212 no 2902 0.161910349775632 4084 4216 Selective myosin light chain kinase inhibitor. SGTC_2733 amorolfine 100 µM -0.987813832842552 0.137984387819195 no 2903 0.161621915831222 4163 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1864 st057645 30.4 µM -0.990384396791963 0.137364166280433 no 2904 0.160993134519113 4115 688666 SGTC_1654 st012436 41.8 µM -0.99130106545226 0.13714345511942 no 2905 0.160769296450129 4017 4323132 SGTC_2214 7179297 48.276 µM -0.993741722509733 0.136556986921688 no 2906 0.160174312356241 4096 769744 SGTC_1473 k844-0725 134 µM -0.993863871398171 0.136527680764735 no 2907 0.160144572736202 4143 54682906 SGTC_1360 1598-0022 39.8 µM -0.994852827075734 0.136290567328815 no 2908 0.159903924391279 4132 761525 SGTC_2301 7769476 200 µM -0.998022986077807 0.135532385486777 no 2909 0.159134106303743 4112 977820 SGTC_2098 5376439 882.5 nM -0.998727509669313 0.135364283402915 no 2910 0.158963355241991 4133 2844116 SGTC_562 3772-2733 112 µM -0.999582576245459 0.135160453218744 no 2911 0.158756279340577 4100 2876874 YIL048W NEO1 SGTC_314 1671-0008 2.74 µM -0.999819794718939 0.135103942551279 no 2912 0.158698862262749 3968 3913060 SGTC_20 0481-0013 4.944 µM -1.00291583505554 0.13436788305116 no 2913 0.157950735837965 4117 182045 SGTC_3078 9116413 49.47 µM -1.00470783428756 0.13394310959834 no 2914 0.157518777331804 4021 17177322 SGTC_379 3970-0972 5.9 µM -1.00545065953136 0.133767301980333 no 2915 0.157339948315293 4091 2898042 YBL034C STU1 SGTC_1036 k216-0215 33.5 µM -1.00659939708916 0.133495737816242 no 2916 0.157063662157779 4078 622330 SGTC_1287 0971-0001 34.6 µM -1.01086582303769 0.132490465616152 no 2917 0.156040326849187 4089 4665869 SGTC_480 am 92016 50 µM -1.01220835075537 0.132175215627264 no 2918 0.155719222128711 4078 2129 K+ channel blocker. SGTC_3146 9095609 49.47 µM -1.01595450259767 0.131298287227613 no 2919 0.154825526434793 4156 17173999 SGTC_2003 4023581 200 µM -1.01660110609213 0.131147332771151 no 2920 0.154671613905536 4147 16641307 SGTC_799 1310-0557 151 µM -1.01961984193969 0.130444172687827 no 2921 0.153954395473616 4169 5354492 SGTC_462 ag-879 158 µM -1.02091032908038 0.130144374020565 no 2922 0.153648462480325 4140 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.02135131641391 0.130042035733753 no 2923 0.153544010907984 4094 6708739 YPR165W RHO1 SGTC_2123 5259487 200 µM -1.0217900475236 0.129940276326021 no 2924 0.15344014041566 4127 2173474 SGTC_3110 9122132 49.47 µM -1.02325752792976 0.129600309151201 no 2925 0.153093049683263 4214 918317 SGTC_1344 1488-0097 29.1 µM -1.02458445440721 0.129293434597782 no 2926 0.152779651353663 4150 747966 SGTC_2390 9097792 176.6 µM -1.02471060244899 0.129264286931995 no 2927 0.152749879413637 4111 4497149 SGTC_1025 k007-0731 70 µM -1.02510297878214 0.129173653886728 no 2928 0.152657300082099 4090 6256118 SGTC_26 0302-0163 425.158 µM -1.0253275646696 0.12912179774498 no 2929 0.152604326862437 4174 3100915 SGTC_3221 9128209 49.47 µM -1.02614341095821 0.128933542977548 no 2930 0.152411995296575 4151 16460723 SGTC_2850 9015429 58.44 µM -1.02649924026223 0.128851495781065 no 2931 0.152328160775543 4150 6457570 SGTC_2840 9008771 71.43 µM -1.02668924042929 0.12880770033732 no 2932 0.152283408667482 4061 2992978 SGTC_2796 7949634 45.45 µM -1.02751088628028 0.128618428104618 no 2933 0.152089980993974 4082 2971588 SGTC_816 0325-0417 81.3 µM -1.03183665786192 0.127625137664114 no 2934 0.151074321651431 4135 68101 SGTC_496 calpeptin 138 µM -1.03599154866613 0.126676118105385 no 2935 0.150103042654684 4140 73364 A calpain inhibitor. SGTC_3184 9108758 49.47 µM -1.03663176950947 0.12653032322868 no 2936 0.149953750713579 4145 902885 SGTC_2081 5214970 32.255 µM -1.03744496465448 0.126345306200715 no 2937 0.149764266011589 4089 2063512 SGTC_1235 benzylparaben 21.5 µM -1.04104017869745 0.125529587594919 no 2938 0.148928450627759 4149 7180 SGTC_2945 9067681 61.76 µM -1.04328938461299 0.12502113773105 no 2939 0.148407143025279 4207 16456930 SGTC_2417 cerulenin 830 nM -1.043947972858 0.124872531569926 no 2940 0.148254730623501 4166 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_483 fpl-64176 144 µM -1.04420712625961 0.124814089138071 no 2941 0.148194785311923 4209 3423 SGTC_1615 st002656 86.5 µM -1.04440790098834 0.124768824990535 no 2942 0.148148354842961 4134 1584458 SGTC_3259 9138485 49.47 µM -1.04481469497331 0.124677149499863 no 2943 0.148054310917679 4133 17646153 SGTC_903 1134-0042 114 µM -1.04874358028433 0.123794154871315 no 2944 0.1471480753546 4156 701009 SGTC_2077 5212015 200 µM -1.05064989991545 0.123367301475979 no 2945 0.146709706966051 3993 780900 SGTC_2163 5671233 125 µM -1.05127725233805 0.123227053684636 no 2946 0.146565635753408 4114 701023 SGTC_1817 st052116 64.4 µM -1.05479250642146 0.122443268008291 no 2947 0.145760116277197 4169 4361398 SGTC_21 0849-0113 22.993 µM -1.05692682515548 0.121969095758627 no 2948 0.145272492357554 4111 1560156 SGTC_2421 5690543 90.72 µM -1.05718910244514 0.121910915864992 no 2949 0.145212646153879 4166 3397993 SGTC_872 0588-0139 234 µM -1.05946656229549 0.121406535807646 no 2950 0.144693674848936 4113 2047100 SGTC_300 r073-0011 5.04 µM -1.06043266716391 0.121193020168883 no 2951 0.14447390359151 4137 2735780 SGTC_1862 st057513 3.81 µM -1.06077532846803 0.121117353216029 no 2952 0.144396008452148 4140 5393163 SGTC_992 3909-8734 162 µM -1.06260425602553 0.120714048906994 no 2953 0.14398072806784 4172 4288319 SGTC_1867 st057372 64 µM -1.06402960021975 0.120400396561443 no 2954 0.14365764526808 4109 688837 SGTC_1311 1190-0148 100 µM -1.06431094724429 0.1203385529874 no 2955 0.143593930195571 4214 1961333 SGTC_2737 bleomycin 30.5 nM -1.06443899292828 0.120310414364716 no 2956 0.143564938728876 4206 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2504 purpurogallin 52.29 µM -1.06478959406911 0.120233391887504 no 2957 0.143485577583388 4057 5281571 An antioxidant. SGTC_613 3914-0030 117 µM -1.06631677348335 0.119898295850354 no 2958 0.143140234806793 3872 1145395 SGTC_1369 1866-0067 208 µM -1.06775391586462 0.119583557695652 no 2959 0.142815765408082 4180 3531355 SGTC_2924 9010168 62.78 µM -1.06801590794322 0.119526243568405 no 2960 0.14275666802502 4246 2993929 SGTC_255 tunicamycin 200.472 nM -1.06944579377835 0.119213779196687 no 2961 0.142434420955615 4087 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1667 st014849 34.6 µM -1.06953863192001 0.119193511785702 no 2962 0.142413515456605 4207 5348460 SGTC_1042 0350-0096 82 µM -1.07163146798471 0.118737271912691 no 2963 0.141942796739161 4153 3122515 SGTC_1073 triclabendazole 3.09 µM -1.07278334384103 0.118486689117043 no 2964 0.141684167846776 4220 50248 An antihelmetic and likely tubulin inhibitor. SGTC_322 k048-0136 19.3 µM -1.07337261305228 0.118358642198147 no 2965 0.14155198364217 4239 6823282 SGTC_2732 terfenadine 20 µM -1.0768095163814 0.117613759651481 no 2966 0.140782686500706 4223 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_580 1123-0028 41 µM -1.0768297495367 0.117609384352685 no 2967 0.140778166040445 4209 1677248 YPR107C YTH1 SGTC_3130 9127414 49.47 µM -1.07843848472946 0.117261873689179 no 2968 0.140419060117966 4172 1494646 SGTC_3147 9097027 49.47 µM -1.07936323770495 0.117062442847055 no 2969 0.140212916193601 4166 25236841 SGTC_731 3966-0296 387 µM -1.08202578043773 0.116489585352582 no 2970 0.139620536345055 4168 660956 SGTC_1207 2099-0101 141 µM -1.08596392236127 0.115645927312716 no 2971 0.138747477063561 4184 5837381 SGTC_272 doxorubicin 8.13 µM -1.09008370050081 0.114768012711311 no 2972 0.137838137773506 4181 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1625 st003711 30.1 µM -1.09102471628316 0.114568151533727 no 2973 0.137631003521305 4259 24207034 YER133W GLC7 SGTC_3097 9117246 49.47 µM -1.09146557032072 0.114474604347892 no 2974 0.137534036849771 4196 16423892 SGTC_1328 1441-0025 69.2 µM -1.09214225247922 0.114331121329215 no 2975 0.137385290090553 4160 4562601 SGTC_3085 9117376 49.47 µM -1.09351684388259 0.114040048687784 no 2976 0.137083468803903 4274 16480349 SGTC_1703 st026983 48.3 µM -1.09375339964943 0.11399001079182 no 2977 0.137031573590521 4204 1104023 SGTC_2778 tioconazole 65.09 nM -1.09556756602346 0.11360678582693 no 2978 0.136634031009359 4081 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2147 5545932 89.7195 µM -1.09576748529506 0.113564611084156 no 2979 0.136590270515363 4208 797404 SGTC_3336 9143619 71.43 µM -1.09590608713234 0.113535378350964 no 2980 0.136559937471386 4226 45595730 SGTC_479 n-linoleoylglycine 10 µM -1.09605235247977 0.113504535113755 no 2981 0.136527932262661 4224 6433346 An anti-infammatory. SGTC_1563 conessine 56.1 µM -1.09669809907196 0.113368436784777 no 2982 0.13638669385357 4274 441082 An anti-amoebic, histamine inhibitor. SGTC_2722 naftopidil 47.16 µM -1.09695905262867 0.113313470934196 no 2983 0.136329646171094 4120 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_31 0508-1974 57.237 µM -1.10165469750781 0.112327652640455 no 2984 0.135305909523747 4127 6810525 SGTC_2434 5670830 169.91 µM -1.10268102804078 0.112113000219243 no 2985 0.135082854249327 4227 1549830 SGTC_627 1391-0720 175 µM -1.10333499778172 0.111976378420138 no 2986 0.134940856782942 4174 997839 SGTC_1845 st056753 3.01 µM -1.10340678665373 0.111961388153392 no 2987 0.134925275392496 4163 5375839 SGTC_1297 1068-0111 14.1 µM -1.10664329187767 0.111287061977565 no 2988 0.134224091075644 4168 767057 SGTC_825 1988-2224 89.6 µM -1.1079156740914 0.111022758806393 no 2989 0.13394911784864 4185 1180859 SGTC_271 rotenone 740 µM -1.1079429190232 0.111017104325422 no 2990 0.133943234210402 4254 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1797 st048695 56.8 µM -1.10965385676594 0.110662425141005 no 2991 0.13357410695542 4174 592262 YIL048W NEO1 SGTC_767 0929-0023 86 µM -1.11240006150748 0.110094833130583 no 2992 0.132983089098355 4212 1204563 SGTC_662 k832-1615 104 µM -1.11340883279134 0.109886863310032 no 2993 0.132766441591315 4232 5878478 SGTC_221 trifluoperazine 10.304 µM -1.11423519248493 0.109716709931602 no 2994 0.13258915069264 4174 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1686 st019653 115.5 µM -1.1142388112663 0.10971596521479 no 2995 0.13258837466198 4188 97252 SGTC_3099 9120367 49.47 µM -1.11442061102785 0.109678556920563 no 2996 0.132549392584657 4250 24824940 SGTC_657 3534-0529 86.7 µM -1.11447762064991 0.109666828138322 no 2997 0.132537170028468 4255 1049549 SGTC_278 4092-0821 23.9 µM -1.11471357108331 0.109618294833926 no 2998 0.132486591783061 4210 877900 SGTC_1123 mangostin 811.285 nM -1.11542966398296 0.109471094111956 no 2999 0.132333171819267 4210 5281650 An antioxidant. SGTC_291 SEC14.278 35.5 µM -1.11737810290672 0.109071289974058 no 3000 0.131916346819324 4262 1068044 SGTC_2122 5258151 111.688 µM -1.11850128156556 0.108841300031562 no 3001 0.131676479739715 4213 2173356 SGTC_2868 9035608 32.47 µM -1.11958703901981 0.108619304363387 no 3002 0.131444890635297 4186 6462614 SGTC_1665 st014639 11.4 µM -1.12383592106454 0.107753702442236 no 3003 0.130541319791074 4261 981133 YIL048W NEO1 SGTC_2412 st077135 33.4 µM -1.12429436496261 0.107660603975026 no 3004 0.13044408406747 4289 13258915 SGTC_1055 3448-0672 86 µM -1.12440385063829 0.107638378753387 no 3005 0.130420869622017 4213 748378 SGTC_1014 4130-3005 69.3 µM -1.12474467158307 0.107569214417907 no 3006 0.130348623035209 4223 743608 SGTC_934 2950-0684 338 µM -1.12502032563602 0.107513298124376 no 3007 0.130290210658463 4254 1121253 SGTC_409 arachidonic acid 100 µM -1.12635370447426 0.107243118577402 no 3008 0.130007917150462 4204 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1761 st044296 37 µM -1.1277228383323 0.106966203830064 no 3009 0.129718494680695 4205 1826700 SGTC_1004 4084-0029 199 µM -1.12773202609336 0.106964347299475 no 3010 0.129716553979858 4237 716894 YLR208W SEC13 SGTC_1167 k781-0610 148 µM -1.1279383933553 0.106922653695978 no 3011 0.12967296899341 4257 4525169 SGTC_1495 4469-0029 237 µM -1.13239203743554 0.1060257126848 no 3012 0.128734825492462 4232 793680 SGTC_2749 bexarotene 57.39 µM -1.13243937541525 0.106016208348733 no 3013 0.128724879280934 4250 82146 An retinoic acid receptor inhibitor. SGTC_1481 3346-2004 36 µM -1.13578345809262 0.105346353429109 no 3014 0.128023600887795 4292 2770522 SGTC_2585 alliin 100 µM -1.13903910529464 0.104697159710894 no 3015 0.127343422055198 4307 87310 A garlic compound which reacts with lipids. SGTC_2998 9066762 71.4286 µM -1.14358994628798 0.103794560324581 no 3016 0.126396866529571 4300 4945196 SGTC_957 1187-1561 14.1 µM -1.14365062898822 0.103782562965243 no 3017 0.126384277995078 4188 1538454 SGTC_1594 piperine 70.1 µM -1.14524904062258 0.103466908870004 no 3018 0.126053004443392 4210 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2238 6671620 73.2395 µM -1.14908666587165 0.10271190134477 no 3019 0.125260123046019 4155 729941 SGTC_733 4069-0007 56.1 µM -1.15091930576271 0.102352766998007 no 3020 0.124882717303812 4247 5717425 YNL287W SEC21 SGTC_2276 7947513 42.08 µM -1.15127526955088 0.102283116389649 no 3021 0.124809503938339 4190 2105100 SGTC_3123 9126162 49.47 µM -1.15328864336038 0.101889813054474 no 3022 0.124395964959901 4299 25239884 SGTC_677 0929-0063 136 µM -1.15332029717794 0.101883638427454 no 3023 0.12438947105113 4233 1539583 SGTC_1067 clotrimazole 1.36 µM -1.15484749989157 0.101586054477469 no 3024 0.124076440834103 4278 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_608 k048-0125 159 µM -1.15640047289581 0.101284098621041 no 3025 0.123758694128678 4290 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.15744997091345 0.101080407703904 no 3026 0.123544283983247 4204 2333 A French combination drug. SGTC_591 4299-0174 154 µM -1.1599132220554 0.100603502826985 no 3027 0.123042069447132 4275 5509088 SGTC_3279 9140807 49.47 µM -1.16218189375111 0.100165723964026 no 3028 0.122580793887017 4296 45595718 SGTC_472 calcifediol 10 µM -1.16239308574792 0.100125041735702 no 3029 0.122537915280445 4303 5283731 A vitamin D metabolite. SGTC_2475 5812728 15.03 µM -1.16251411917812 0.100101732324445 no 3030 0.122513346438116 4181 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_282 k297-0036 65.7 µM -1.16724679235433 0.0991933869840345 no 3031 0.121555359601699 4256 5061378 SGTC_783 0848-0141 92.7 µM -1.16782932090229 0.0990819998158278 no 3032 0.121437809209819 4174 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.16887372738987 0.0988825245680409 no 3033 0.121227255054495 4211 688761 SGTC_2629 bisabolol 100 µM -1.17256300765733 0.0981802468773618 no 3034 0.120485545598704 4306 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1835 st008666 49.2 µM -1.17988045440677 0.0967981485197621 no 3035 0.119023882341571 4198 690455 SGTC_2151 5563267 85.4165 µM -1.18086661963299 0.0966129823927919 no 3036 0.118827856880919 4314 5310824 SGTC_2642 cholecalciferol 100 µM -1.1814626433386 0.0965011969405933 no 3037 0.118709492603009 4256 9821465 A vitamin D precursor, similar to steriods. SGTC_2033 5192550 145 µM -1.18423016890225 0.0959833868157021 no 3038 0.118160981410285 4267 182073 SGTC_3290 9121031 71.43 µM -1.18852991674159 0.0951829522731795 no 3039 0.117312350263652 4274 17014854 SGTC_974 1326-0144 138 µM -1.18949134580575 0.0950046484679574 no 3040 0.117123187254018 4302 5411856 SGTC_1547 harmine 94.2 µM -1.19254163347112 0.0944405798273416 no 3041 0.116524468075261 4222 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1283 0922-0125 16.4 µM -1.1936528561702 0.0942357039555869 no 3042 0.116306894474073 4270 3360884 SGTC_1442 4112-3290 3 µM -1.19690599735148 0.0936378080363885 no 3043 0.115671598159183 4274 704353 SGTC_1413 3910-0535 34.4 µM -1.19952439908365 0.0931586093096778 no 3044 0.115162051643425 4309 2876951 SGTC_2481 5478948 45.16 µM -1.20075342563327 0.0929343087811002 no 3045 0.114923431602015 4305 77792 SGTC_2705 st078069 42.8 µM -1.20112366218798 0.0928668179666703 no 3046 0.114851617783599 4320 1530061 SGTC_2337 9009472 200 µM -1.20172755549673 0.0927568113875646 no 3047 0.114734550684388 4270 5742383 SGTC_2675 theaflavin digallate 100 µM -1.20295535890461 0.0925334491160195 no 3048 0.114496797995873 4228 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1954 st077032 68.9 µM -1.20491876933265 0.0921770923756423 no 3049 0.114117331022536 4241 698907 SGTC_101 0490-5701 117.494 µM -1.20575492184863 0.0920256404830011 no 3050 0.113956000683828 4127 4661669 SGTC_2442 5158906 48.48 µM -1.20670460969851 0.0918538475673307 no 3051 0.113772961598419 4295 1893835 SGTC_883 0850-0245 24.6 µM -1.20896882884044 0.0914452221936624 no 3052 0.113337410543028 4367 6823229 YPR165W RHO1 SGTC_2513 baicalein 25.65 µM -1.2102906656306 0.0912072930364286 no 3053 0.113083689097561 4287 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1209 2323-2347 50.3 µM -1.2128219641033 0.0907529438740453 no 3054 0.112598948004316 4298 5412760 SGTC_3129 9127257 49.47 µM -1.21624514802534 0.0901411824534521 no 3055 0.111945774898232 4253 837894 SGTC_3228 9131799 49.47 µM -1.21971466178605 0.0895242728148331 no 3056 0.111286530768034 4328 17015818 SGTC_1865 st057639 52.2 µM -1.22006279526585 0.0894625454204621 no 3057 0.111220535490751 4290 688818 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.22307262700002 0.0889301928621851 no 3058 0.11065113315893 4337 4620898 SGTC_1678 st019265 80.2 µM -1.22312605050961 0.088920765129064 no 3059 0.110641045362951 4289 5367020 SGTC_497 capsazepine 133 µM -1.22870845377329 0.0879397255269982 no 3060 0.10959056773837 4256 2733484 A calcium channel blocker. SGTC_361 000s-0510 1.45 µM -1.23015117542406 0.0876875021956537 no 3061 0.109320249663529 4231 660 SGTC_163 TUB2.036 7.546 µM -1.23237587610052 0.0872996280149682 no 3062 0.108904354051401 4278 15992207 YJR013W GPI14 SGTC_2734 clemastine 41.6 µM -1.23375269963401 0.0870602228092846 no 3063 0.108647534917877 4366 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1080 nisoldipine 24.4 µM -1.23522039599965 0.0868055567544263 no 3064 0.108374245233417 4313 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2900 5328528 85.29 µM -1.23629096184576 0.086620149831285 no 3065 0.108175214737502 4319 795359 SGTC_304 1310-0298 97 µM -1.23762279575632 0.0863899083239022 no 3066 0.107927978947289 4090 1550234 SGTC_180 1486-1293 102.781 µM -1.24367583060545 0.0853492504243038 no 3067 0.106809447401678 4260 4140536 SGTC_360 0957-0399 1.01 µM -1.24464748569639 0.0851830786384137 no 3068 0.106630678616256 4327 6752301 YPR165W RHO1 SGTC_3319 9138450 16.7555 µM -1.24671716864058 0.0848299312245635 no 3069 0.106250610670017 4257 2029690 SGTC_103 0844-0104 51.839 µM -1.25182965279741 0.0839623007339594 no 3070 0.105315971302696 4174 5375804 SGTC_1424 4048-1941 275 µM -1.2528891345027 0.0837833344864616 no 3071 0.105123028347129 4406 X1424 SGTC_2210 7115885 190.385 µM -1.25599208077154 0.0832608374538677 no 3072 0.104559420656038 4421 2927039 SGTC_1818 st052136 56.3 µM -1.25600233163777 0.0832591154064481 no 3073 0.104557562361431 3996 674169 SGTC_1573 oleylamine 1.06 µM -1.25642817602057 0.0831876012852954 no 3074 0.104480385702171 4323 5356789 An amine of the fatty acid oleic acid. SGTC_687 k029-0044 34.9 µM -1.25707076836769 0.0830797750698478 no 3075 0.104364005504679 4409 5829338 SGTC_3309 9129340 25.759 µM -1.25895257287779 0.0827646151780737 no 3076 0.104023731458096 4350 17158987 SGTC_227 fluconazole 33.516 µM -1.25962195717213 0.0826527255640219 no 3077 0.103902885387003 4331 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2234 tolnaftate 200 µM -1.26110866244828 0.0824046255362981 no 3078 0.103634850032815 4418 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_86 0417-1630 471.922 µM -1.2614662842729 0.0823450296801312 no 3079 0.103570449977182 4339 3634867 SGTC_2400 5203494 178.7 µM -1.26291845696235 0.0821033659352691 no 3080 0.103309243067901 4247 6777674 SGTC_429 1112-0049 25.5 µM -1.26316326492366 0.0820626788273851 no 3081 0.103265255834937 4328 2836170 SGTC_3239 9133757 49.47 µM -1.26564738652394 0.0816506763226092 no 3082 0.102819676370594 4379 17036923 SGTC_1176 0848-0131 83.3 µM -1.266908085908 0.0814421812539752 no 3083 0.102594078570818 4393 6769040 SGTC_2801 7907800 81.82 µM -1.26763872675486 0.0813215314473948 no 3084 0.10246349772299 4352 6620925 SGTC_1952 st077036 64.1 µM -1.26821214627271 0.081226937870765 no 3085 0.102361100293411 4355 2937007 SGTC_1947 st076332 61.6 µM -1.26980121132818 0.0809652331570239 no 3086 0.102077724569782 4218 24208416 SGTC_2359 9039622 200 µM -1.27143138301143 0.0806974204361709 no 3087 0.101787611929331 4302 6463596 SGTC_2247 cerulenin 830 nM -1.27292878703515 0.0804520094176076 no 3088 0.101521656515611 4391 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_357 1325-0123 420 µM -1.27298673392101 0.0804425237902103 no 3089 0.101511374692734 4355 1098503 SGTC_1394 3474-0001 65.7 µM -1.27314361320272 0.0804168476442817 no 3090 0.10148354257682 4315 5017666 YIL048W NEO1 SGTC_906 1165-0455 526 µM -1.27382701106532 0.0803050693972824 no 3091 0.101362365094024 4333 3252859 SGTC_233 rapamycin 362 pM -1.27392063490871 0.0802897651984546 no 3092 0.101345772286882 4327 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_384 k007-0144 5.16 µM -1.27766923388087 0.0796788106463017 no 3093 0.100683038806692 4280 6824886 SGTC_583 1488-1091 88.9 µM -1.27837450715791 0.0795642578587023 no 3094 0.100558704136408 4451 4303273 SGTC_2654 protoveratrine a 100 µM -1.28315100625649 0.0787917209112504 no 3095 0.0997195884298546 4360 5702278 A heart drug and vasodilator. SGTC_2591 skatole 100 µM -1.28409248887872 0.0786401210472737 no 3096 0.0995547979272981 4372 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_45 0kpi-0036 14.9 µM -1.28545581968027 0.0784209861187912 no 3097 0.0993165229659175 4355 2795021 SGTC_423 5-fluorouracil 457 µM -1.28651098778121 0.0782517017720855 no 3098 0.0991323933009392 4291 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_837 0091-0265 12.5 µM -1.28658450968599 0.0782399167291465 no 3099 0.099119572841379 4341 759367 SGTC_509 pifithrin 175 µM -1.28796069171174 0.0780195727866981 no 3100 0.0988798233864424 4429 4817 A p53 inhibitor. SGTC_2349 9023730 187.07 µM -1.28867122406447 0.0779059921277526 no 3101 0.098756205288392 4399 4126287 SGTC_1087 pterostilbene 9.05 µM -1.29097041590742 0.0775393195209908 no 3102 0.0983569680962954 4360 5281727 Similar to reservatol, lowers cholesterol. SGTC_210 3551-0445 56.827 µM -1.29299583226331 0.0772173953197369 no 3103 0.0980062502824453 4383 2865180 YOR207C RET1 SGTC_2783 7738165 71.43 µM -1.29307936560815 0.07720414017996 no 3104 0.0979918054859955 4345 17201110 SGTC_1340 1486-1359 257 µM -1.29325586520989 0.0771761387637101 no 3105 0.0979612898610179 4297 4309068 SGTC_3134 9127454 49.47 µM -1.29343425200141 0.0771478457889597 no 3106 0.0979304550300603 4411 24262820 SGTC_3022 9087993 49.47 µM -1.29406800318514 0.0770473936397897 no 3107 0.0978209662684037 4435 17173644 SGTC_1717 st033143 58.0435 µM -1.29499848587722 0.0769000884901818 no 3108 0.0976603759034235 4421 674616 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.29549533086948 0.0768215204563976 no 3109 0.0975747055109156 4390 5357218 A potent inhibitor of glutathione S-transferases. SGTC_406 estrone 100 µM -1.29826641163525 0.0763844376773231 no 3110 0.097097902047741 4332 5870 A steroid. SGTC_2150 5556613 200 µM -1.30648606867179 0.0750990797125434 no 3111 0.0956936567886478 4403 743190 SGTC_1458 k015-0034 6.33 µM -1.30802420555772 0.0748603945925971 no 3112 0.0954325496832693 4401 3598957 SGTC_3199 9111318 49.47 µM -1.31043508688229 0.0744874437271272 no 3113 0.0950243452295529 4295 8548020 SGTC_123 0083-0120 66.675 µM -1.31112766976343 0.0743805674326872 no 3114 0.0949073169647496 4352 16001701 SGTC_2152 5568786 200 µM -1.31257094129082 0.0741582244998114 no 3115 0.0946637833603123 4397 5399883 SGTC_2465 5809242 33.21 µM -1.31377274073525 0.0739734691725052 no 3116 0.0944613467872594 4425 2731748 SGTC_1662 st014054 52 µM -1.31470534289845 0.0738303406603889 no 3117 0.0943044751196166 4432 2838777 SGTC_2614 arthonioic acid 13.39 µM -1.31650203898447 0.0735551945284841 no 3118 0.0940027972537419 4230 6710684 SGTC_3056 9094900 49.47 µM -1.31860821133699 0.0732336542298597 no 3119 0.0936500635552394 4363 25236784 SGTC_1863 st057641 20.1 µM -1.32411813891941 0.0723975640313801 no 3120 0.0927319061426832 4407 3921635 SGTC_3031 9088762 49.47 µM -1.32570753029277 0.0721577500536406 no 3121 0.0924682960803761 4347 205253 SGTC_1921 5740136 50 µM -1.33158997980036 0.0712754762601102 no 3122 0.0914974796967403 4328 1774243 SGTC_37 0566-0070 1.56 µM -1.33392205563126 0.070928003247626 no 3123 0.0911147012300817 4299 1626686 SGTC_773 4358-1457 44.6 µM -1.33759797150726 0.0703829456180136 no 3124 0.0905137630304754 4388 1186886 SGTC_2423 st077119 87.2 µM -1.3379546401162 0.0703302313647316 no 3125 0.0904556118701257 4322 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1040 k898-0338 155 µM -1.3428112611638 0.0696154591225274 no 3126 0.0896665480223959 4388 20969351 SGTC_1002 4049-0206 172 µM -1.3448470242882 0.0693175149170799 no 3127 0.0893373204402005 4361 4662749 SGTC_1826 st055655 41.6 µM -1.34689332831131 0.0690190188897434 no 3128 0.0890072952874536 4410 676168 SGTC_2186 6124449 200 µM -1.3494514274797 0.068647261380278 no 3129 0.0885960059056253 4406 3834182 YLR033W RSC58 SGTC_2444 5485484 36.41 µM -1.35247459130776 0.0682099111671649 no 3130 0.0881117708495821 4462 6790631 SGTC_1288 0973-0013 65.5 µM -1.35522280845121 0.067814205439909 no 3131 0.0876732899524371 4443 4315430 SGTC_3013 9080133 71.4286 µM -1.35615727074947 0.0676800603200541 no 3132 0.0875245670235284 4467 17050193 SGTC_419 nsc-638432 893 µM -1.36592646918134 0.0662899067031793 no 3133 0.0859810219148113 4386 368090 SGTC_2134 5324836 1.464 µM -1.36716750325539 0.0661149025119456 no 3134 0.085786404349092 4389 699272 SGTC_1840 st055363 71 µM -1.37168221740385 0.0654812789350655 no 3135 0.0850811932858704 4447 676033 SGTC_3170 9103054 49.47 µM -1.37685772007058 0.0647607211683769 no 3136 0.0842781205964589 4394 16432970 SGTC_1389 3405-0187 19 µM -1.37723497747398 0.0647084393394851 no 3137 0.0842198055077767 4404 799890 SGTC_1873 rapamycin 2 nM -1.37843566337292 0.0645422616748543 no 3138 0.0840344093941906 4368 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_508 roscovitine 141 µM -1.3793706294741 0.064413089971098 no 3139 0.0838902550112229 4497 160355 A CDKinase inhibitor. SGTC_1660 st012960 28.1 µM -1.38167633460139 0.0640954001611114 no 3140 0.0835355519664123 4447 24207266 SGTC_1178 0988-0033 191 µM -1.38553299881022 0.0635667371179747 no 3141 0.0829447747471217 4482 5392207 SGTC_864 0469-0573 172 µM -1.38792364633184 0.0632407398922984 no 3142 0.0825801482609536 4403 689425 SGTC_2312 7706453 155.7 µM -1.38803697213715 0.0632253187573108 no 3143 0.0825628935759518 4425 976098 SGTC_2228 7354201 200 µM -1.39159922037974 0.0627420665684526 no 3144 0.0820218975449822 4519 753451 SGTC_1256 0570-0116 285 µM -1.3938595040958 0.0624369338063912 no 3145 0.0816800175611258 4427 410638 SGTC_2389 9091542 195.52 µM -1.3943558456389 0.0623700841081636 no 3146 0.0816050873129388 4399 3626624 YOL127W RPL25 SGTC_2026 5148700 152 µM -1.39643522143139 0.0620906301942791 no 3147 0.081291737456721 4416 79838 SGTC_2231 micatex 6.853 µM -1.40229071352012 0.0613089395349636 no 3148 0.080414226188319 4465 20737 An antifungal of unknown mechanism. SGTC_1674 st016616 23.6 µM -1.41346152788197 0.0598390165711042 no 3149 0.0787600328118808 4392 625830 SGTC_3070 9117005 49.47 µM -1.4147311301973 0.0596737167040979 no 3150 0.078573671688878 4540 8779016 SGTC_234 nsc-17383 10.7 µM -1.41685694674781 0.0593977406875052 no 3151 0.0782623780812304 4453 408974 SGTC_1117 retinoic acid 1.10837 µM -1.41816504013338 0.0592284203666714 no 3152 0.0780712930047135 4481 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1286 0929-0070 131 µM -1.41887383225664 0.0591368321682478 no 3153 0.0779679012642946 4512 1420408 SGTC_2135 5326629 150.42 µM -1.4205234481037 0.0589241033894671 no 3154 0.0777276735730047 4391 5020077 SGTC_3037 9091026 49.47 µM -1.42122672294745 0.0588335942382201 no 3155 0.077625429149329 4325 25236398 YIL048W NEO1 SGTC_1462 k081-0014 26.5 µM -1.42223233577716 0.0587043647621274 no 3156 0.0774794072657569 3883 3270634 SGTC_2345 9052315 157.45 µM -1.43114728594766 0.0575684421136002 no 3157 0.0761940038010916 4454 6469265 SGTC_328 k915-0120 63.5 µM -1.43131979546685 0.0575466330682043 no 3158 0.0761692915488527 4464 6624543 SGTC_1731 st035964 63 µM -1.43360601906257 0.057258216841805 no 3159 0.0758423624396309 4373 6739575 SGTC_1370 2001-0092 44.6 µM -1.43439553588545 0.057158880816558 no 3160 0.0757297104283388 4450 790957 SGTC_459 nigericin 15.3 µM -1.442052190376 0.0562025524066055 no 3161 0.0746438254809287 4493 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1501 4491-0275 38.4 µM -1.44407089239988 0.0559525264909657 no 3162 0.0743595174216936 4464 5104718 SGTC_931 2812-0076 566 µM -1.44897744510685 0.0553484840313155 no 3163 0.073671940743613 4384 3450959 SGTC_2106 5357045 167.29 µM -1.45041969262837 0.0551719126229374 no 3164 0.0734707594325319 4500 668842 SGTC_3094 9117742 49.47 µM -1.45543719662147 0.054561094528888 no 3165 0.0727741325305917 4434 17149698 SGTC_1788 fluconazole 20 µM -1.457575789845 0.0543023785690482 no 3166 0.072478753430095 4479 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1386 3228-0095 33.8 µM -1.45920528545615 0.0541059028881823 no 3167 0.0722543072567124 4466 870181 SGTC_3033 9090887 49.47 µM -1.45951944838181 0.0540680876121311 no 3168 0.0722110958746022 4482 19325384 SGTC_17 0960-0276 49.807 µM -1.46048824868313 0.0539516064184449 no 3169 0.0720779674320808 4471 6821114 SGTC_1933 st074711 15.9 µM -1.46100082875622 0.0538900580927871 no 3170 0.0720076069962259 4459 17250958 SGTC_138 0850-0259 40.9225 µM -1.46462013116629 0.0534570491702856 no 3171 0.0715122932360925 4413 6813004 SGTC_2684 capsaicin 100 µM -1.46510821022545 0.0533988675401849 no 3172 0.0714456985119006 4491 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1841 st054148 70 µM -1.46533400152524 0.0533719689943241 no 3173 0.0714149070898888 4487 675442 SGTC_680 0417-1641 114 µM -1.46867669880137 0.0529750079892504 no 3174 0.0709602502291382 4497 2835990 SGTC_958 1222-0007 33 µM -1.47311340539625 0.0524517488524636 no 3175 0.0703602296721733 4521 7312461 SGTC_330 1488-0319 80.1 µM -1.47561883887855 0.0521580791159797 no 3176 0.0700231224359514 4513 6846614 SGTC_2520 obtusaquinone 4.71 µM -1.47786385988135 0.0518960439278468 no 3177 0.0697221106669125 4510 5967872 SGTC_3316 9136639 10.545 µM -1.47980729495023 0.0516700550732652 no 3178 0.0694623406572221 4470 4903665 SGTC_1606 st000094 49.2 µM -1.48517957092642 0.0510494185036941 no 3179 0.0687481310782433 4502 1242210 SGTC_504 lovastatin 124 µM -1.48931347962855 0.0505758964437103 no 3180 0.0682024198926832 4496 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3207 9114163 49.47 µM -1.49107900509069 0.0503747320379229 no 3181 0.067970376859509 4463 849233 SGTC_1253 0550-0034 176 µM -1.49113526993668 0.0503683317062317 no 3182 0.0679629920054481 4486 5969915 SGTC_610 4215-0184 155 µM -1.49178945914917 0.0502939628536332 no 3183 0.0678771740615008 4505 5605015 SGTC_1506 4226-2149 212 µM -1.49188336707128 0.0502832944982279 no 3184 0.0678648618906197 4496 991114 SGTC_2270 7924575 90.91 µM -1.49337833057683 0.0501137028111936 no 3185 0.0676690909647335 4459 1262135 SGTC_873 0591-4978 488 µM -1.49407559387687 0.0500347599504044 no 3186 0.0675779311224541 4512 3305145 SGTC_2721 ifenprodil 61.44 µM -1.49505981178001 0.0499234974236964 no 3187 0.0674494165212106 4487 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_222 nsc-310342 10.666 µM -1.49716646450946 0.049686010616339 no 3188 0.0671749745014389 4514 432556 SGTC_91 0417-1751 58.384 µM -1.50685878460276 0.0486049689709534 no 3189 0.0659234289233872 4591 6795624 SGTC_455 paf C-16 10 µM -1.50785387527293 0.0484950533086678 no 3190 0.0657959649420488 4463 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_676 falcarinol 140 µM -1.50884134228837 0.0483861763138762 no 3191 0.0656696664160972 4513 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3203 9113543 49.47 µM -1.5101909019928 0.0482376916713692 no 3192 0.0654973597596467 4519 17018012 SGTC_3135 9127742 49.47 µM -1.51559504729744 0.0476467523326408 no 3193 0.0648108900881093 4556 3643468 SGTC_2070 5230947 200 µM -1.51611377197568 0.0475903364745149 no 3194 0.0647452932534217 4582 2835538 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.51901345092092 0.0472759557941958 no 3195 0.0643795551301204 4496 803109 SGTC_951 1171-0579 82.7 µM -1.52007088625369 0.0471617245840647 no 3196 0.0642465804035027 4448 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2658 polymyxin b sulfate 77.05 µM -1.5282942601038 0.0462809142448479 no 3197 0.0632197472007505 4525 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1224 0823-0416 294 µM -1.5297791065697 0.0461232883236169 no 3198 0.0630357074711334 4535 3598164 SGTC_3000 9075062 71.4286 µM -1.53016038667488 0.0460828826630311 no 3199 0.062988516997079 4490 17057871 SGTC_445 e6 berbamine 66 µM -1.53260939276471 0.0458240298280076 no 3200 0.0626860629043672 4516 6610268 A calcium/calmodulin antagonist. SGTC_2521 angolensin 13.4 µM -1.53290423665389 0.0457929446479795 no 3201 0.0626497259310264 4539 821428 A flavenoid. SGTC_1470 k295-0292 231 µM -1.53712386572567 0.0453499263232443 no 3202 0.0621314898414554 4576 5045612 SGTC_2873 9040596 71.43 µM -1.54140832771471 0.0449036350841379 no 3203 0.0616087192531094 4480 6463863 SGTC_966 1300-0360 30.2 µM -1.5423383529988 0.0448072275241006 no 3204 0.061495696789659 4510 70588 SGTC_2133 5320837 200 µM -1.54416738236187 0.0446181143058366 no 3205 0.06127389422118 4523 2841355 SGTC_1995 st072814 61.1 µM -1.54773412041921 0.0442511794818479 no 3206 0.0608431617898407 4524 5769371 SGTC_375 3970-0961 9.27 µM -1.54825160441392 0.0441981449730888 no 3207 0.0607808656708792 4484 2898222 SGTC_2420 aureobasidin a 50 nM -1.55139856667015 0.0438767298580317 no 3208 0.0604030992574062 4576 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_701 4424-0219 185 µM -1.55381026007562 0.0436316896876891 no 3209 0.0601148412281224 4542 2911779 SGTC_928 2764-0428 58.7 µM -1.55598539747065 0.0434116330804241 no 3210 0.0598557823851168 4544 662578 SGTC_276 colchicine 750 µM -1.55854283551593 0.0431540464759703 no 3211 0.0595523109876692 4557 2833 A microtubule depolymerizer. SGTC_1274 0865-0114 173 µM -1.56761109299355 0.0422506204558864 no 3212 0.0584859608405794 4523 870624 SGTC_1302 1159-0335 255 µM -1.56821970409929 0.0421905396511594 no 3213 0.0584149337312213 4552 649284 SGTC_2830 7992007 71.43 µM -1.56846933207806 0.0421659169054307 no 3214 0.058385820844129 4426 1952075 SGTC_1365 1672-3266 55.4 µM -1.56996904741521 0.0420182330314007 no 3215 0.0582111562089449 4550 6415873 SGTC_666 0272-0154 136 µM -1.58163989642857 0.0408832067086584 no 3216 0.056865900366024 4540 6870312 SGTC_1734 st037168 69.4 µM -1.58399391491289 0.0406573129924407 no 3217 0.0565975519285168 4538 708907 SGTC_76 0433-0009 400.328 µM -1.58839575784988 0.0402376267828664 no 3218 0.0560984380701607 4582 2841569 SGTC_2211 7117706 200 µM -1.5899454554815 0.0400907136527906 no 3219 0.0559235501827233 4512 822771 SGTC_1514 1189-1591 158 µM -1.59294050347707 0.0398080147911828 no 3220 0.0555867694085791 4547 767698 YMR146C TIF34 SGTC_2157 5649910 96.377 µM -1.59854659351156 0.0392832192504625 no 3221 0.0549606922953988 4539 2858091 SGTC_970 1315-0089 19.5 µM -1.59960271338661 0.0391849871103844 no 3222 0.0548433730700293 4527 6811083 YLR033W RSC58 SGTC_3241 9133421 49.47 µM -1.60259330867569 0.0389079091947423 no 3223 0.0545122360098093 4624 17018221 SGTC_1945 st075991 56.6 µM -1.60661326239517 0.0385379774476943 no 3224 0.0540696156866921 4536 1084980 SGTC_1452 4194-0072 190 µM -1.61120472213822 0.0381189654512934 no 3225 0.0535675544645039 4592 1343545 SGTC_587 k089-0003 57 µM -1.61235408783152 0.0380146590596449 no 3226 0.0534424548135013 4476 9659696 SGTC_1605 st000082 49.1 µM -1.61784325884785 0.0375197166944523 no 3227 0.0528481905263991 4510 1114022 SGTC_1839 st053978 48 µM -1.6323301900408 0.0362387020848654 no 3228 0.0513049733226029 4582 3788398 SGTC_2317 5986382 200 µM -1.63603318096905 0.0359170732367795 no 3229 0.0509163215868799 4580 877883 SGTC_2942 9052777 62.25 µM -1.63911527493135 0.0356511598821242 no 3230 0.0505946272085412 4559 6469503 SGTC_456 gingerol 170 µM -1.65051074843877 0.0346819721703889 no 3231 0.0494192583878926 4573 442793 A herb. SGTC_1659 st012954 42.1 µM -1.650873949133 0.0346514412478809 no 3232 0.0493821581115095 4550 24207262 SGTC_2969 9091408 28.7 µM -1.65323136201371 0.0344538115494587 no 3233 0.0491418930015426 4502 4286311 SGTC_700 3453-2283 142 µM -1.65325303097805 0.0344519992731284 no 3234 0.0491396888611045 4600 565664 SGTC_230 MPP+ 141.667 µM -1.6601307403367 0.0338807295113835 no 3235 0.0484440769980227 4547 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1352 1496-0991 99 µM -1.66216219844415 0.0337134929100557 no 3236 0.048240128588641 4578 3000039 SGTC_1429 4049-0205 9.46 µM -1.66802064327395 0.0332350061935755 no 3237 0.0476558144530369 4626 22774478 SGTC_3112 9123419 49.47 µM -1.67081351250651 0.0330088761611791 no 3238 0.0473792593461376 4613 17015854 SGTC_1752 st044819 83.042 µM -1.67201341296679 0.032912114044271 no 3239 0.0472608385943871 4521 441209 YML126C ERG13 SGTC_2213 7173844 200 µM -1.67305144091144 0.0328285943347885 no 3240 0.0471585848746712 4597 892728 SGTC_1172 0370-0043 85 µM -1.68152808871344 0.0321530822365242 no 3241 0.0463301926344459 4598 376585 SGTC_3312 9133330 71.43 µM -1.68339704483817 0.0320056977084648 no 3242 0.0461491274827075 4590 17617324 SGTC_1989 st071868 50.2 µM -1.68802583746571 0.0316430750302755 no 3243 0.0457031346325084 4579 16414057 SGTC_962 1254-0300 21.5 µM -1.69228594077324 0.0313123425058697 no 3244 0.0452957335766251 4567 7340576 SGTC_2093 5331342 194.4 µM -1.7061550926841 0.030255359050775 no 3245 0.0439896036663289 4616 33839 SGTC_1108 betulinic acid 729.144 nM -1.71238365461746 0.0297903880904305 no 3246 0.0434129946437716 4579 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1049 3226-0134 66 µM -1.72078136912331 0.029172886054315 no 3247 0.0426452522194007 4612 5702385 SGTC_35 0133-0054 64.071 µM -1.73535035069573 0.0281268334725316 no 3248 0.0413393842331761 4562 99677 SGTC_2332 7982454 138.89 µM -1.73554400111805 0.0281131424968932 no 3249 0.0413222474433107 4503 2981748 SGTC_529 4076-0302 30.3 µM -1.74275825674208 0.0276070387484661 no 3250 0.0406879253696972 4593 5816522 SGTC_1479 0549-0158 134 µM -1.74573911863708 0.0274001502076591 no 3251 0.0404281471554414 4644 5440202 SGTC_948 3448-0295 75.3 µM -1.746791215426 0.0273274381783034 no 3252 0.0403367804683424 4583 678569 SGTC_2120 5538279 151.968 µM -1.75190392969719 0.0269763781466218 no 3253 0.0398951643665934 4609 2058197 SGTC_2571 chrysanthemic acid 100 µM -1.7645400684875 0.0261248493899614 no 3254 0.0388205477654239 4597 2743 An insecticide. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.77317022385448 0.0255562901286032 no 3255 0.0381002522281556 4542 5355888 SGTC_538 2922-0838 53.3 µM -1.77388614033808 0.0255095941562198 no 3256 0.038040992857419 4635 777039 SGTC_2848 9016370 25.97 µM -1.77909376769185 0.0251720700485601 no 3257 0.0376121951542885 4591 7894410 SGTC_3003 9075612 71.4286 µM -1.79061702774414 0.0244384957811309 no 3258 0.0366773863237302 4634 6501993 SGTC_954 1189-0853 2.85 µM -1.80059892636302 0.0238176311334811 no 3259 0.0358830592638109 4573 2828194 SGTC_949 1165-0505 146 µM -1.80534577234426 0.0235270660261279 no 3260 0.0355102956013399 4609 6244267 SGTC_2241 6772625 37.8075 µM -1.80975539107572 0.0232598207051964 no 3261 0.035166864243446 4437 2285411 SGTC_2094 5332512 191.667 µM -1.82517089474103 0.022345559144939 no 3262 0.0339876222330595 4655 755774 SGTC_1747 st037496 66.6 µM -1.8295925774194 0.0220889817030064 no 3263 0.0336554422409559 4589 723305 SGTC_3337 9144342 33.5465 µM -1.82976382106582 0.0220790951546077 no 3264 0.0336426314521863 4639 17682949 SGTC_589 1227-0070 34.1 µM -1.83030434754189 0.0220479129991393 no 3265 0.0336022208273727 4680 2841384 SGTC_2775 cyproheptadine 69.59 µM -1.83782674830358 0.021617801603608 no 3266 0.033043969404659 4629 2913 A selective serotonin reuptake inhibitor. SGTC_2495 cafestol 54.53 µM -1.85441457339695 0.0206943575421076 no 3267 0.0318399357169715 4635 16667697 An anti-infammatory. SGTC_1378 2093-0007 380 nM -1.85730234331372 0.0205370587818063 no 3268 0.0316340756121096 4653 3618014 SGTC_724 3910-0327 137 µM -1.87119917548198 0.0197941837377709 no 3269 0.0306587395113966 4659 2885483 SGTC_2114 5491910 81.25 µM -1.87141194055814 0.0197829897269549 no 3270 0.0306440025627437 4647 2849228 SGTC_3294 9122953 26.2835 µM -1.87349384336471 0.0196737397548947 no 3271 0.0305001110591336 4632 16459826 SGTC_2833 9001315 45.46 µM -1.88216548082093 0.01922418073273 no 3272 0.0299067754568601 4586 2989378 SGTC_441 propafenone 146 µM -1.89993112167786 0.0183303849569208 no 3273 0.0287210796189697 4648 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1980 st071811 45.7 µM -1.90231241330642 0.018213315210815 no 3274 0.0285651619012492 4698 4974850 SGTC_599 1935-0052 86.5 µM -1.90529051525644 0.0180678021287188 no 3275 0.0283711588521389 4653 9557311 SGTC_90 0870-0863 4.608 µM -1.91725614719215 0.0174930985511064 no 3276 0.0276026990656491 4683 1738164 SGTC_366 0181-0206 4.31 µM -1.91949620767077 0.0173872621313789 no 3277 0.0274607828870212 4633 274874 SGTC_1854 st056233 32.9 µM -1.92306190077467 0.0172199214980436 no 3278 0.0272361381914122 4612 5393174 SGTC_1943 st076331 65.2 µM -1.93316448909023 0.0167532529391864 no 3279 0.0266079688913214 4637 24208415 SGTC_757 1066-0008 322 µM -1.93880088606134 0.0164976240115005 no 3280 0.0262627941012865 4668 6842497 SGTC_3210 9128157 49.47 µM -1.9589178014543 0.0156123025057924 no 3281 0.0250612069627333 4609 17590849 SGTC_1754 st042065 16.137 µM -1.96277481623455 0.0154473003338567 no 3282 0.0248361726487787 4449 1126236 YIL048W NEO1 SGTC_392 N-ethylmaleimide 8.33 µM -1.96354959993124 0.0154143364548675 no 3283 0.024791173548314 4666 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2323 6148992 148.28 µM -1.96892909542218 0.0151871220697127 no 3284 0.0244806169362117 4647 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1984 st072354 53.1 µM -1.99083929225696 0.0142911806384835 no 3285 0.023249279042087 4604 5762938 SGTC_2362 9071156 126 µM -1.99790943334743 0.0140119590330556 no 3286 0.0228632398748902 4659 653133 SGTC_1454 4239-0054 42.6 µM -2.00095681719302 0.0138930663548643 no 3287 0.0226985218681919 4714 1340767 SGTC_2365 9042475 200 µM -2.00386138598785 0.0137805562526617 no 3288 0.0225424554549698 4681 6464479 SGTC_195 4234-0266 16.654 µM -2.01272543356118 0.0134420481604463 no 3289 0.0220717610964175 4709 2303354 SGTC_92 0063-0024 660.874 µM -2.01341010420034 0.013416202626305 no 3290 0.0220357517506563 4729 3594437 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.01868862690463 0.0132183811735853 no 3291 0.0217597964084593 4683 6710655 SGTC_2285 7945142 200 µM -2.01990430375799 0.0131731803446177 no 3292 0.0216966573967603 4675 2970608 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -2.02661016602322 0.0129262384969885 no 3293 0.0213511480375665 4698 390807 SGTC_3196 9111891 49.47 µM -2.02982903478684 0.0128091331213738 no 3294 0.0211869602697771 4662 18891510 SGTC_1960 st011366 51.8 µM -2.0471532403362 0.0121944992457711 no 3295 0.0203215204550636 4721 3972846 SGTC_761 k216-0224 480 µM -2.04827897863836 0.0121554595914716 no 3296 0.0202663357754874 4700 1340404 SGTC_527 4476-4215 268 µM -2.05203241423015 0.012026075335789 no 3297 0.0200832561784761 4690 4418754 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.09087469088132 0.0107557559355655 no 3298 0.0182696492029359 4691 6708561 SGTC_1531 st059297 52.4 µM -2.0951343608432 0.0106238227893818 no 3299 0.0180795251037475 4707 7566702 SGTC_281 1672-3440 14.9 µM -2.10057783915881 0.0104572772531995 no 3300 0.0178390205342323 4728 6833000 SGTC_2049 5262831 67.185 µM -2.10084128955311 0.0104492749249723 no 3301 0.0178274502948245 4676 763417 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.10851970488241 0.0102183753148324 no 3302 0.017493030069473 4692 61125 An anti-inflammatory. SGTC_3211 9128781 49.47 µM -2.13902222333506 0.00934451758119801 no 3303 0.0162169342937558 4616 17194361 SGTC_2451 5856223 45.7 µM -2.15033180328465 0.00903753405714173 no 3304 0.0157644892372751 4698 2179896 SGTC_389 tpck 16.7 µM -2.17091702350656 0.00850138910129207 no 3305 0.0149687226287995 4721 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2330 7979373 200 µM -2.17401451800765 0.00842317863682176 no 3306 0.0148520224548978 4666 1863007 SGTC_2428 5615643 7.78 µM -2.17534793671737 0.00838970528937811 no 3307 0.0148020264097917 4714 2253075 SGTC_337 1315-0038 354 µM -2.17950844054471 0.00828601195059902 no 3308 0.0146469591642509 4715 1626437 SGTC_2885 9057732 51.95 µM -2.18230488201487 0.00821694958443691 no 3309 0.0145435194737379 4717 6471414 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.19772111363539 0.00784522651320761 no 3310 0.0139844930024093 4633 4330530 SGTC_2897 9048598 12.99 µM -2.20593229580647 0.00765333803224644 no 3311 0.0136943702719432 4710 6467404 SGTC_2690 usnic acid 100 µM -2.21098566441452 0.00753730978195398 no 3312 0.013518414897272 4709 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1105 epirubicin 18.1 µM -2.23070538172097 0.0070992204851807 no 3313 0.0128503254614538 4740 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2892 9047358 58.44 µM -2.25813507260831 0.00652725204461892 no 3314 0.0119686198150519 4733 6466771 SGTC_2315 7733312 200 µM -2.28050662162805 0.00609133488135708 no 3315 0.0112888292586916 4686 726316 SGTC_1443 4112-3303 14 µM -2.28196602267976 0.00606381574212725 no 3316 0.0112456731639466 4760 704433 SGTC_579 4491-1009 110 µM -2.30728989776859 0.00560353029022417 no 3317 0.0105193321622032 4748 1271041 SGTC_1690 st023502 41.2 µM -2.31824800127585 0.00541416638934005 no 3318 0.0102179233189072 4754 24207482 SGTC_765 1319-0117 244 µM -2.33349407972805 0.0051601697078324 no 3319 0.00981111434491452 4737 3487746 YGL099W LSG1 SGTC_124 0136-0217 7.121 µM -2.33975078090696 0.00505904129338285 no 3320 0.00964830580524254 4759 3976905 SGTC_2836 9010338 19.48 µM -2.3554650862069 0.00481278818742418 no 3321 0.00924976769815377 4702 2994051 SGTC_787 4152-0075 138 µM -2.36108138435123 0.00472740436894461 no 3322 0.00911086562594246 4735 9566539 SGTC_2565 isoliquiritigenin 100 µM -2.36189497322628 0.0047151481748717 no 3323 0.00909089617696268 4712 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1557 sumaresinolic acid 42.3 µM -2.36196858912901 0.00471404059807935 no 3324 0.00908909117501569 4726 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1778 st046819 58.9 µM -2.38493258278306 0.0043796594741826 no 3325 0.00854112574549294 4775 671715 SGTC_1990 st072050 59.8 µM -2.39013775949705 0.00430687839690289 no 3326 0.00842102708117569 4757 17233948 SGTC_2250 alverine citrate 130 µM -2.39082283550104 0.00429738031576039 no 3327 0.00840533127868293 4632 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2872 9044037 25.97 µM -2.44112884450484 0.00364907137845018 no 3328 0.0073207149816956 4780 6465195 SGTC_2059 5238311 157 µM -2.46787535922027 0.00334139632577172 no 3329 0.00679588183588258 4733 703021 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -2.4717578210055 0.00329872824430402 no 3330 0.00672252817686814 4770 5106787 A p450 inhibitor. SGTC_2695 st077686 51.995 µM -2.47250403888369 0.00329058370059086 no 3331 0.00670850987800968 4729 2876092 SGTC_2343 7990716 14.84 µM -2.48209444615826 0.00318750774400393 no 3332 0.00653063257200884 4742 6456862 SGTC_1438 4092-1045 4 µM -2.51291218266909 0.00287565981609924 no 3333 0.0059869568505011 4788 1351342 SGTC_2564 betulinic acid 100 µM -2.52006900172011 0.00280729637307494 no 3334 0.00586659154970206 4713 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1137 ixabepilone 100 µM -2.52758528713629 0.00273708099393722 no 3335 0.0057424962627711 4725 154225 A novel microtubule stabilizer. SGTC_771 0250-0039 27.3 µM -2.53182197813368 0.00269820515576004 no 3336 0.00567357924851118 4745 3005115 SGTC_541 4513-1321 94 µM -2.54391907510149 0.00258993115974188 no 3337 0.00548082385011429 4750 747515 SGTC_1993 st073995 70.8 µM -2.56191188253029 0.00243614095888862 no 3338 0.00520488630944081 4765 3098394 SGTC_307 1501-1223 22.3 µM -2.60910622700824 0.00207122448851645 no 3339 0.00453895286319406 4777 2830329 SGTC_2028 5153890 36.43 µM -2.61638611728817 0.00201957693943443 no 3340 0.00444330014417114 4764 2830968 YPR165W RHO1 SGTC_926 2268-1401 59.4 µM -2.68898648991585 0.00156491085369262 no 3341 0.00358346598584457 4760 2931578 SGTC_2409 alverine citrate 63.97 µM -2.69364679094896 0.00153918898178887 no 3342 0.00353375083108656 4741 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_99 0109-0120 622.8 µM -2.70691179170221 0.00146807092452613 no 3343 0.00339561495763255 4779 759414 SGTC_77 0828-0286 12.516 µM -2.84379477990542 0.000890741653641275 yes 3344 0.0022289875441673 4727 745345 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -2.86388785678403 0.000826288316347843 yes 3345 0.002092380691562 4790 94937 An inhibitor of serotonin biosynthesis. SGTC_1738 st035555 74 µM -2.88269193465002 0.000769884856336548 yes 3346 0.00197146422077132 4778 5331140 SGTC_1564 D-Arginine 115 µM -2.94799895714157 0.000600403152689319 yes 3347 0.0015991907184445 4769 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_69 0096-0274 206.684 µM -3.12090667497976 0.00030371458905932 yes 3348 0.000901475810348731 4780 6741392 SGTC_924 2046-0044 21.3 µM -3.12422332706615 0.00029967114716714 yes 3349 0.000891375455769707 4782 3623589 SGTC_756 0508-1999 28.3 µM -3.16265338692812 0.000256333729171292 yes 3350 0.000781691755742562 4796 6753853 SGTC_2841 9004761 38.96 µM -3.18528969029325 0.000233618197412881 yes 3351 0.00072304585008299 4768 2991039 SGTC_2016 5121758 140 µM -3.22924448286208 0.000194775281888507 yes 3352 0.000620588694464822 4768 2795203 SGTC_2313 7726885 200 µM -3.3264225254205 0.000129286635347432 yes 3353 0.000439842352406492 4789 726423 SGTC_2402 5553605 200 µM -3.45042085737738 7.54525952888753e-05 yes 3354 0.000279856625562336 4794 6758546 SGTC_2804 7954240 19.48 µM -3.61645764041036 3.56915451021467e-05 yes 3355 0.000149331082530859 4794 828705 SGTC_2040 5100729 123 µM -3.85051355099685 1.17751959601638e-05 yes 3356 5.89352039654259e-05 4807 11840 YJR013W | YDR381W GPI14 | YRA1