SGTCid condition conc unit CAF120|YNL278W.score CAF120|YNL278W.strain.pval CAF120|YNL278W.strain.significant CAF120|YNL278W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2781 5567276 71.43 µM 5.4311336465585 1.04811341888517e-08 yes 1 2.79985881372944e-08 17 2853274 SGTC_70 0141-0289 43.283 µM 4.70600645964178 5.9190148433679e-07 yes 2 1.26308258321336e-06 123 352408 SGTC_689 0833-0039 98 µM 4.34636189754408 3.58527156623592e-06 yes 3 6.920706514365e-06 27 5374726 SGTC_2069 5228469 200 µM 4.34035193862532 3.69070126213731e-06 yes 4 7.11273470065088e-06 8 2835210 SGTC_2149 5554786 194.827 µM 4.12662967782566 1.01010404316259e-05 yes 5 1.84059231096281e-05 31 745063 YPR165W RHO1 SGTC_1955 wogonin 32.4 µM 4.01493552753976 1.6783709435629e-05 yes 6 2.97310234227954e-05 18 5281703 A flavanone. SGTC_1217 1183-1422 255 µM 4.00023192707736 1.79270900188721e-05 yes 7 3.16402173733236e-05 10 2849664 SGTC_2788 5282734 71.43 µM 3.92989759892047 2.44968472558356e-05 yes 8 4.24910227050332e-05 48 743706 SGTC_1031 k035-0009 16 µM 3.92487839862487 2.50440189409677e-05 yes 9 4.33867800326708e-05 33 5180959 SGTC_178 4092-0806 87.505 µM 3.88528730035772 2.9784661776494e-05 yes 10 5.11044725547091e-05 102 2169044 SGTC_602 3130-1533 38.1 µM 3.86510246386247 3.25172007068008e-05 yes 11 5.55212866940127e-05 19 720941 SGTC_1679 SEC14.276 6.7 µM 3.83973693044133 3.62881593804567e-05 yes 12 6.15831080501631e-05 66 1005053 YMR079W SEC14 SGTC_71 0417-1750 47.813 µM 3.7397714172819 5.55676334552833e-05 yes 13 9.20938361282395e-05 51 6811472 SGTC_253 dyclonine 31.25 µM 3.60349520488158 9.77401163276694e-05 yes 14 0.000156983271092186 36 3180 An oral anasthetic. SGTC_1879 gemcitabine 100 µM 3.53045061566589 0.00013128029580305 yes 15 0.000207426226428324 24 60750 A nucleoside analog which inhibits DNA replication. SGTC_1893 st059353 36.1 µM 3.50710535131641 0.000144098732926071 yes 16 0.000226504879900617 39 3112488 SGTC_612 0302-0167 22.4 µM 3.46260717454735 0.000171840828698199 yes 17 0.000267484404873496 57 235821 SGTC_217 ketoconazole 989 nM 3.44022997287682 0.00018760956166101 yes 18 0.000290610045306783 43 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2556 citropten 84.59 µM 3.43875179482904 0.000188697435233947 yes 19 0.000292201389784398 47 2775 A potential DNA crosslinker. SGTC_1040 k898-0338 155 µM 3.41732915356759 0.000205140305595446 yes 20 0.000316193857640744 33 20969351 SGTC_2143 5623677 140.463 µM 3.39324431745122 0.000225220379989663 yes 21 0.000345350022839273 12 5375313 SGTC_256 clotrimazole 625 nM 3.3778896826104 0.000238963942712438 yes 22 0.000365221888260961 47 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2162 5663267 200 µM 3.31812249663917 0.000300256984014559 yes 23 0.000453123654934317 28 6456493 SGTC_2794 7785382 27.27 µM 3.22309452226585 0.000428526709812974 yes 24 0.000634068496468801 71 2205081 SGTC_3180 9109287 49.47 µM 3.18535560340103 0.000492321367678388 yes 25 0.000722881168486552 35 18891271 SGTC_2698 st077697 67.5 µM 3.16830039324327 0.000523944633899668 yes 26 0.000766665000289755 38 3154499 SGTC_2354 9060492 162 µM 3.15551640556493 0.000548869471866739 yes 27 0.000801071279298641 50 6471895 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 3.15503636356651 0.000549826424955148 yes 28 0.000802390512445034 33 17037758 SGTC_1660 st012960 28.1 µM 3.13989368946828 0.000580816771547346 yes 29 0.000845045774698995 76 24207266 SGTC_2789 5281112 71.43 µM 3.11861993882786 0.000627087184529273 yes 30 0.000908500862527018 77 765948 SGTC_1319 1306-0155 43.7 µM 3.1143276980003 0.000636825964568562 yes 31 0.000921823009513706 73 3122360 SGTC_57 miconazole 162.5 nM 3.09205318358886 0.000689645670975876 yes 32 0.00099388616230015 56 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2314 7727897 200 µM 3.0425434259548 0.00082182731450047 yes 33 0.00117293983188757 60 900724 SGTC_1391 3442-0225 151 µM 3.04178545122194 0.000824021029914457 yes 34 0.00117589728800734 46 5227075 SGTC_1870 st057514 26.5 µM 3.04072520655656 0.000827098609544722 yes 35 0.00118004559311196 61 5393161 SGTC_1597 7-benzyloxygramine 47.5 µM 3.02156170829616 0.000884579604445944 yes 36 0.00125737188572885 219 260807 SGTC_1059 3448-6867 171 µM 3.00181628143102 0.000947628367561018 yes 37 0.00134187044247727 47 3934407 SGTC_132 0417-1715 25.805 µM 2.98209061012124 0.00101471149203644 no 38 0.00143143626906719 55 6769098 SGTC_3 0833-0587 95.581 µM 2.95271382337433 0.00112272128580538 no 39 0.00157496916166958 61 5382644 SGTC_3129 9127257 49.47 µM 2.94942164425266 0.00113546044869012 no 40 0.00159184646185641 67 837894 SGTC_909 3448-9333 149 µM 2.92683783965378 0.00122648067615323 no 41 0.00171213685790139 51 3344074 SGTC_1876 myriocin 605 nM 2.90575563882477 0.00131742572364464 no 42 0.00183183720436479 76 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1000 4048-0884 8.67 µM 2.88703622989351 0.00140330122188673 no 43 0.00194444723790114 78 13040088 SGTC_739 1486-1183 203 µM 2.80378798850354 0.00185056508016378 no 44 0.00252530521004227 60 4346692 SGTC_2813 7971799 71.43 µM 2.80027163559898 0.00187203789567256 no 45 0.00255298102948337 84 2234054 SGTC_3147 9097027 49.47 µM 2.7947383551262 0.00190628610229884 no 46 0.0025970867375118 77 25236841 SGTC_1019 4262-0212 3.4 µM 2.78996882461788 0.00193626289665454 no 47 0.00263565585060494 156 4677213 SGTC_368 fentichlor 4.58 µM 2.75012489345477 0.00220391288590935 no 48 0.00297862770363475 90 7329 A pesticide. SGTC_2717 st081029 62.2815 µM 2.73839758432293 0.00228884464167514 no 49 0.00308696933983014 54 5292846 SGTC_2297 7971671 152.32 µM 2.70992345441556 0.00250753062869024 no 50 0.00336493687581299 89 909016 SGTC_2054 5233173 129 µM 2.68976718029876 0.00267357149823051 no 51 0.00357509420707682 161 6889 SGTC_1246 0422-0085 105 µM 2.68483307457355 0.00271570114366897 no 52 0.00362830192795943 118 264295 SGTC_37 0566-0070 1.56 µM 2.63089223980411 0.0032169334584179 no 53 0.00425805170045743 120 1626686 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.62806418207782 0.00324537452985026 no 54 0.00429361559930339 139 2724 A muscle relaxant with antifungal properties. SGTC_1757 st041620 31.8375 µM 2.59462858159516 0.0035991878697605 no 55 0.00473465932707992 115 5289815 SGTC_334 1502-1024 68.5 µM 2.59186653031326 0.00362990958839772 no 56 0.00477283985877082 91 3296216 SGTC_2629 bisabolol 100 µM 2.59085603108308 0.00364120782180325 no 57 0.00478687669230523 111 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1245 0418-0076 17.2 µM 2.57975349003155 0.00376743761352025 no 58 0.00494354323131185 110 6790114 SGTC_3257 9139206 32.98 µM 2.57847996975925 0.00378216485866528 no 59 0.00496180264030397 47 4910041 SGTC_637 1181-0519 7.26 µM 2.56390285802102 0.00395445144422034 no 60 0.00517512541435948 219 6252091 YGR060W ERG25 SGTC_1364 1653-0028 37.6 µM 2.5629239517619 0.00396626913673526 no 61 0.00518973902650845 113 5718652 SGTC_821 1114-0266 29.2 µM 2.55664681544454 0.00404280346807327 no 62 0.00528432310256412 103 3123235 SGTC_1066 ketoconazole 628 nM 2.54343845838059 0.00420817961848599 no 63 0.00548836957226162 109 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3332 9141069 11.198 µM 2.5361440749739 0.00430207986292973 no 64 0.00560403058930654 93 17332883 SGTC_989 1501-0895 10.3 µM 2.4984547923468 0.0048177311262011 no 65 0.00623680256114024 69 2830112 SGTC_1985 st071382 65.5 µM 2.46730126062786 0.00528482577762216 no 66 0.00680678841993511 110 6123237 SGTC_1180 1193-0155 285 µM 2.4672464899281 0.00528568125906894 no 67 0.00680782974776121 116 2921347 SGTC_2316 5844804 197.44 µM 2.46375783131173 0.00534042618427917 no 68 0.00687444850519007 155 776813 SGTC_1354 1498-1681 81 µM 2.46172088062854 0.00537262315194192 no 69 0.00691361137033808 119 5754243 SGTC_3306 9127676 59.7925 µM 2.42843272604165 0.00592380274069984 no 70 0.00758211906502173 128 41905287 SGTC_1256 0570-0116 285 µM 2.42356141446953 0.00600853320051414 no 71 0.00768457716161328 127 410638 SGTC_342 k048-0088 23.3 µM 2.38978298868141 0.00662619849822281 no 72 0.00842916535574278 126 6820570 SGTC_374 0880-0231 82.3 µM 2.36562351148563 0.00710176941422956 no 73 0.00899986911974696 139 6833587 SGTC_1575 cyproterone acetate 48 µM 2.35535434437704 0.00731287110854665 no 74 0.00925252509107874 142 9880 An androgen receptor antagonist and liver toxin. SGTC_6 0844-0013 19.835 µM 2.35488838648861 0.00732257957830564 no 75 0.00926413499414853 345 1584900 SGTC_3328 9140624 29.0385 µM 2.35294485244878 0.00736319673624663 no 76 0.00931269808139391 143 4904392 SGTC_48 0382-0018 55 µM 2.35216633323813 0.0073795223251153 no 77 0.00933221333390859 117 762596 SGTC_3150 9097574 49.47 µM 2.349951127177 0.00742614996920879 no 78 0.00938793809121521 92 17217476 SGTC_1922 5578187 25 µM 2.34810715236838 0.00746516139791291 no 79 0.0094345460772174 164 1350412 SGTC_1359 1582-0056 520 nM 2.33685543874144 0.00770713977540526 no 80 0.00972335102676888 154 3661189 SGTC_1787 fluconazole 80 µM 2.33590471998733 0.00772789870741116 no 81 0.00974810395956713 204 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_688 0527-0193 473 µM 2.33323578999684 0.00778643796690115 no 82 0.00981788669029057 105 4007154 SGTC_2052 5265182 7.135 µM 2.32904557213404 0.00787913184303908 no 83 0.00992832579503595 154 1239884 SGTC_1376 2910-0861 41.3 µM 2.32468983379576 0.00797651480395959 no 84 0.0100442756387492 155 1112859 SGTC_814 3342-0569 96 µM 2.31438001175503 0.00821124348363142 no 85 0.010323443164706 166 4346283 SGTC_891 0929-0073 133 µM 2.30510398835032 0.0084275989639021 no 86 0.010580375092205 132 5603632 SGTC_1669 st015249 58.4 µM 2.29741883638845 0.00861062265847358 no 87 0.0107974441244405 106 722793 SGTC_1396 3511-0007 98.6 µM 2.29597757935303 0.00864533211416827 no 88 0.0108385816798336 137 X1396 SGTC_3153 9100258 49.47 µM 2.29532666044904 0.00866104822578702 no 89 0.0108572054229328 163 25236848 SGTC_1091 telmisartan 47.6 µM 2.27710339739134 0.00911132827676834 no 90 0.0113900259357285 139 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_312 4092-0653 6.84 µM 2.27468472324005 0.00917260630377177 no 91 0.0114624247843575 237 1148278 SGTC_1198 1612-1005 86.7 µM 2.25276249370462 0.00974466831215126 no 92 0.0121370641081747 146 6998509 SGTC_291 SEC14.278 35.5 µM 2.24235376440575 0.0100270308788514 no 93 0.0124692587518012 140 1068044 SGTC_222 nsc-310342 10.666 µM 2.22726735313181 0.0104489548565192 no 94 0.0129647055267875 80 432556 SGTC_2130 NSC 7 2.4545 µM 2.22017642570194 0.0106525574076414 no 95 0.013203396956815 203 21448 SGTC_123 0083-0120 66.675 µM 2.20460182216481 0.0111119174873352 no 96 0.0137410238969327 199 16001701 SGTC_470 aa-861 153 µM 2.19847143275459 0.0112973984837611 no 97 0.0139577640710077 229 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_645 0845-0943 5.41 µM 2.19002566262218 0.0115573376800104 no 98 0.014261187862177 152 1885106 SGTC_1162 k048-0130 20.1 µM 2.18947417438299 0.011574490283236 no 99 0.0142811968122164 158 6797406 SGTC_1454 4239-0054 42.6 µM 2.18444026279621 0.0117320814220873 no 100 0.0144649561831686 211 1340767 SGTC_3148 9097893 49.47 µM 2.17582944646434 0.0120059699625004 no 101 0.014784007983821 190 17174100 SGTC_3234 9132280 49.47 µM 2.16790502874969 0.0122629080062023 no 102 0.0150829565876335 187 17612295 SGTC_762 1165-0429 115 µM 2.15616161764297 0.012652429323271 no 103 0.0155355237332574 166 5967793 SGTC_815 1582-0027 36.9 µM 2.15292671541617 0.0127615922790201 no 104 0.0156622192567283 177 3128206 SGTC_2247 cerulenin 830 nM 2.14698608811111 0.0129641841610858 no 105 0.0158971945896156 173 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3155 9099265 49.47 µM 2.14464996086151 0.0130446110699537 no 106 0.0159904222632566 173 25236499 SGTC_2438 5259590 200 µM 2.14103088461926 0.0131700582341699 no 107 0.0161357737679049 167 1201127 SGTC_346 4513-0042 7.16 µM 2.13907047267486 0.0132384457965127 no 108 0.0162149806739303 215 2827372 SGTC_3213 9129884 49.47 µM 2.1379675960848 0.0132770535332932 no 109 0.0162596866392463 150 17190742 SGTC_936 3005-4620 401 µM 2.12580393241243 0.0137093521065155 no 110 0.0167597942332876 213 777207 SGTC_1583 clindamycin 39.6 µM 2.12521772252924 0.013730489334921 no 111 0.0167842249510748 177 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_414 piperonyl butoxide 100 µM 2.12212200226915 0.0138425799487698 no 112 0.0169137471001046 139 5794 A potent inhibitor of cytochrome P450. SGTC_2871 9038510 12.99 µM 2.11843608486468 0.0139770689405977 no 113 0.0170690762734974 177 4945164 SGTC_366 0181-0206 4.31 µM 2.11405715888904 0.0141383065334764 no 114 0.0172551928301131 245 274874 SGTC_248 streptozotocin 5.23457 mM 2.11010373614784 0.0142852506726952 no 115 0.0174247107785468 203 5300 DNA alkylating agent. SGTC_320 4092-0846 5.34 µM 2.10995817092099 0.0142906861787017 no 116 0.0174309794875828 196 1359356 SGTC_2160 5660466 132.927 µM 2.1046103088663 0.0144916176377797 no 117 0.0176626217657046 171 2859134 SGTC_1106 tegaserod maleate 11.7 µM 2.10330537973242 0.0145410143141932 no 118 0.0177195417455635 209 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3244 9134489 49.47 µM 2.10132525451944 0.0146162465691386 no 119 0.0178062121560844 191 16584271 SGTC_1333 1482-0047 286 µM 2.10000509790404 0.0146665900640013 no 120 0.0178641963398649 219 3811116 SGTC_1327 1436-0082 2.18 µM 2.09906438851697 0.0147025544979587 no 121 0.0179056125677211 184 15992205 SGTC_2474 5321570 43.32 µM 2.0760306286139 0.0156071354711595 no 122 0.018945559156533 164 2841384 SGTC_1692 fluoroquinolonic acid 71 µM 2.06962255343371 0.0158671301326291 no 123 0.0192438521759076 151 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_201 4262-0159 12.803 µM 2.06558480437483 0.0160328538457574 no 124 0.0194338502350462 168 1341029 SGTC_1337 1486-1011 40.3 µM 2.05541962968601 0.0164566512568021 no 125 0.0199192455584773 171 X1337 SGTC_2524 avocatin b 10.57 µM 2.05022618522334 0.0166768488262376 no 126 0.0201711819303759 167 6710748 SGTC_2482 5981709 142.65 µM 2.04426532890865 0.0169326865668206 no 127 0.0204636712123385 245 877755 SGTC_2308 7584454 197.62 µM 2.03537614888727 0.0173204369514508 no 128 0.0209065196739128 245 893577 SGTC_1035 k081-0041 55.2 µM 2.02859729702638 0.0176212080095487 no 129 0.0212496620532768 217 731709 SGTC_2124 5246320 200 µM 2.02048964862433 0.0179867799622049 no 130 0.0216663113944834 210 579342 SGTC_1927 st060202 13.8 µM 2.01950057431044 0.0180318165709225 no 131 0.0217176088389986 201 688887 SGTC_649 1123-0311 367 µM 2.00993647389721 0.0184722906861019 no 132 0.022218956396365 290 693629 YIL048W NEO1 SGTC_875 0709-0210 25.7 µM 2.00588378665002 0.0186616826470692 no 133 0.0224343242371906 243 6251364 SGTC_912 3474-0017 2.18 µM 1.98353786241152 0.0197358980876738 no 134 0.0236536910878317 228 3360550 SGTC_1123 mangostin 811.285 nM 1.97929944392977 0.0199454618528271 no 135 0.0238911510897776 268 5281650 An antioxidant. SGTC_893 0958-0369 48.9 µM 1.97859698218578 0.0199803760198235 no 136 0.0239306998542675 258 6819948 SGTC_1776 st049249 45.9 µM 1.96023783663616 0.0209114291237954 no 137 0.0249839989899039 255 1822314 SGTC_3210 9128157 49.47 µM 1.95149097290698 0.0213677708512505 no 138 0.0254993345043182 284 17590849 SGTC_1377 2944-0135 198 µM 1.95131125095187 0.021377234901601 no 139 0.0255100157480769 265 1894137 SGTC_2757 clomiphene 4.22 µM 1.94635095688522 0.021639843195714 no 140 0.0258062982225748 278 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3132 9126706 49.47 µM 1.94356007837702 0.0217887927795882 no 141 0.0259742619570541 217 850858 SGTC_1061 3448-9325 110 µM 1.94039354938334 0.021958838630144 no 142 0.0261659399730121 175 723482 SGTC_1084 voriconazole 435 nM 1.92892739779717 0.0225839863921468 no 143 0.0268699379990358 215 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1492 4158-0558 28.5 µM 1.92091877975511 0.0230294700184717 no 144 0.0273709738933034 222 3967268 SGTC_1703 st026983 48.3 µM 1.91280135672018 0.0234885351858915 no 145 0.027886743708415 235 1104023 SGTC_932 2857-0803 154 µM 1.90829663782672 0.0237465958854959 no 146 0.0281764436610868 252 674898 SGTC_1469 k284-2957 126 µM 1.90686014476126 0.0238293875374811 no 147 0.0282693502051391 210 23884841 SGTC_2155 5570423 76 µM 1.90143624985409 0.0241441823003158 no 148 0.0286224476125929 229 797402 SGTC_2321 7390090 138.78 µM 1.90138739608583 0.0241470334975975 no 149 0.0286256446018879 234 649046 SGTC_1569 carminic acid 40.6 µM 1.89778390641809 0.0243581210968889 no 150 0.0288622770444294 252 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_9 0092-0002 10.449 µM 1.89701716378545 0.0244032351903134 no 151 0.0289128364164649 252 759368 SGTC_351 caspofungin 25 nM 1.89608910538401 0.024457934701102 no 152 0.0289741314810508 392 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3081 9117243 49.47 µM 1.89483756028821 0.0245318633793661 no 153 0.0290569627104195 230 45595589 SGTC_1349 flufenamic acid 69 µM 1.88631177839158 0.0250404869054109 no 154 0.0296264764961481 226 3371 A non-steroidal anti-inflammatory. SGTC_639 0833-0042 114 µM 1.8830687511389 0.025236263587473 no 155 0.0298455257039886 290 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2793 7325131 81.82 µM 1.87736067206746 0.0255839670697037 no 156 0.0302343389181052 225 4176441 SGTC_623 k072-0108 16.9 µM 1.87673489665716 0.0256223285397133 no 157 0.0302772186323564 258 5382803 SGTC_910 3454-3003 490 µM 1.87459566745265 0.0257538320827962 no 158 0.0304241848399624 290 820824 SGTC_3263 9137018 49.47 µM 1.87413473757218 0.0257822403927232 no 159 0.0304559282441354 256 43844957 SGTC_279 1273-0055 2.93 µM 1.87269148443299 0.0258713615162258 no 160 0.0305554999763694 278 2847562 SGTC_1201 1889-3372 45.9 µM 1.86906832706762 0.0260962284651766 no 161 0.0308066544414313 216 5392199 SGTC_1345 1488-0192 31.4 µM 1.86888116024189 0.0261078890145161 no 162 0.0308196749866264 253 658348 SGTC_2063 5246145 200 µM 1.86877290433341 0.0261146353788038 no 163 0.0308272080529777 277 711240 SGTC_1168 k815-0004 80.5 µM 1.85900174103969 0.0267295937601045 no 164 0.0315134458009118 237 642433 SGTC_2045 5106652 78.05 µM 1.8548912779469 0.0269918801325362 no 165 0.0318058768755318 234 673349 SGTC_2349 9023730 187.07 µM 1.85044268446369 0.0272781593944337 no 166 0.0321248858561742 282 4126287 SGTC_3320 9137005 35.139 µM 1.84912084072726 0.0273637101816626 no 167 0.0322201828408203 228 4908713 SGTC_509 pifithrin 175 µM 1.84473789581325 0.0276489804530443 no 168 0.032537837712202 205 4817 A p53 inhibitor. SGTC_1368 1852-0141 284 µM 1.84442537174087 0.0276694158558015 no 169 0.03256058628189 274 2838987 SGTC_1701 st028638 40.4 µM 1.83666222758929 0.0281810880740509 no 170 0.0331298873592129 278 3490878 SGTC_2986 9022445 71.43 µM 1.82308382084954 0.0290949785379425 no 171 0.0341453483185713 280 6459286 SGTC_2539 epi(13)torulosol 80 µM 1.82151679478709 0.0292020140942848 no 172 0.0342641680369283 283 6708597 SGTC_2976 9009005 19.48 µM 1.81477958944079 0.0296659310545738 no 173 0.0347788941212108 267 2993148 SGTC_2747 doxorubicin 7.63 µM 1.81377202097897 0.0297358340825173 no 174 0.0348564158647447 140 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2804 7954240 19.48 µM 1.81230561338743 0.0298378145735594 no 175 0.034969493844711 310 828705 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.8045186037044 0.0303842301517538 no 176 0.035575022704657 310 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_263 alizarin 107.927 µM 1.80009423371271 0.0306983652413621 no 177 0.0359228799773347 380 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1874 staurosporine 7.6 µM 1.7953338055131 0.0310393593566401 no 178 0.0363002660115681 310 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2750 bromebric acid 70.15 µM 1.78962045865455 0.0314527437832198 no 179 0.036757473638182 342 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3190 9110366 49.47 µM 1.78683494935836 0.0316559314604386 no 180 0.0369820844150027 226 17123768 SGTC_2723 salbutamol 83.58 µM 1.78231855819099 0.0319876818697143 no 181 0.037348649015162 167 9884233 β2-adrenoceptor agonist SGTC_2874 9043904 71.43 µM 1.78174658010397 0.0320299004709749 no 182 0.0373952835864376 222 4463428 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.78076855671596 0.0321021965076306 no 183 0.0374751340655464 319 5377381 SGTC_1604 st002052 72.4 µM 1.77766611167687 0.0323324229977058 no 184 0.0377293543050665 294 6254834 YHR062C RPP1 SGTC_1021 4476-0760 85.3 µM 1.76902121838959 0.0329811406177128 no 185 0.0384451668488733 315 746768 SGTC_2523 spermine 47.74 µM 1.76310061149862 0.0334315857406892 no 186 0.038941761062997 277 1103 A DNA binding polyamine. SGTC_2363 9053361 176 µM 1.75489963166954 0.0340638792609535 no 187 0.0396382385980746 321 6469797 YMR079W SEC14 SGTC_2687 chenodiol 100 µM 1.74796293739821 0.0346063430230032 no 188 0.0402352226802187 274 5702181 A cholesterol synthesis inhibitor. SGTC_2272 7805186 180 µM 1.74554023508844 0.0347974671842027 no 189 0.0404454375652276 269 2956062 YPR165W RHO1 SGTC_3178 9107506 49.47 µM 1.74526898402293 0.0348189197095011 no 190 0.040469029093605 298 8897194 SGTC_1338 1486-1223 76 µM 1.73831118666971 0.0353729151663117 no 191 0.0410779981461418 315 3444526 SGTC_2770 toltrazuril 17.5 µM 1.733645054402 0.0357484770744855 no 192 0.0414905405820314 324 68591 Kills coccidiodes. SGTC_1 0258-0098 57.368 µM 1.73270058774659 0.0358248903857746 no 193 0.0415744500042208 249 6790032 YDR047W HEM12 SGTC_177 1327-0068 8.361 µM 1.72851252506472 0.0361653451709878 no 194 0.0419481887217936 357 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2521 angolensin 13.4 µM 1.72318371417856 0.0366023584285421 no 195 0.0424276539312213 277 821428 A flavenoid. SGTC_2284 7945075 39.21 µM 1.71538414513937 0.0372497775046447 no 196 0.0431374101582722 353 1245402 SGTC_1712 st032288 53.4 µM 1.71300672752289 0.0374489702799651 no 197 0.043355650964492 549 2883011 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.71108835175877 0.0376103355292301 no 198 0.0435324020638718 196 77254 SGTC_1437 4092-1038 11.6 µM 1.71053437208074 0.0376570393327258 no 199 0.0435835515137474 333 3977136 SGTC_555 4296-0685 37 µM 1.71044564572283 0.0376645238928237 no 200 0.0435917482039199 321 2908540 YHR072W ERG7 SGTC_2239 6685329 187.64 µM 1.71040349887128 0.0376680796387973 no 201 0.0435956422367723 347 805680 SGTC_2 0422-0095 29 µM 1.70144895356452 0.0384297725695671 no 202 0.0444293577574618 224 6790840 SGTC_2777 climbazole 1.536 µM 1.70051949874249 0.0385095481659951 no 203 0.0445166259515456 366 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_197 4544-0043 41.561 µM 1.6954421716995 0.0389477234097643 no 204 0.0449957858028815 387 896523 SGTC_2133 5320837 200 µM 1.68457699546898 0.0398990355031326 no 205 0.0460351064065872 336 2841355 SGTC_3312 9133330 71.43 µM 1.68024071266365 0.040283938357476 no 206 0.0464552455240314 324 17617324 SGTC_2450 5739737 12.93 µM 1.67096281029792 0.0411176066613096 no 207 0.0473645118877386 326 2262825 SGTC_747 3448-8087 38.7 µM 1.65758186744013 0.0423445368074592 no 208 0.0487009460325226 365 5168703 SGTC_799 1310-0557 151 µM 1.65271390038643 0.0427981734459863 no 209 0.0491945520244193 355 5354492 SGTC_773 4358-1457 44.6 µM 1.65154713757806 0.0429074833892712 no 210 0.0493134519647218 401 1186886 SGTC_1360 1598-0022 39.8 µM 1.64533138384668 0.0434936237139882 no 211 0.049950745594123 434 761525 SGTC_2592 piperlongumine 83.33 µM 1.64459844931322 0.0435631627907135 no 212 0.0500263234328237 329 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2439 5492030 7.2 µM 1.64262701113094 0.0437506534958862 no 213 0.0502300643017448 322 5722370 SGTC_993 3909-8757 62.7 µM 1.63835987268143 0.0441587031018603 no 214 0.0506733223546532 296 4288324 YLR208W SEC13 SGTC_1494 4358-1428 177 µM 1.63656799759073 0.044330965220841 no 215 0.0508603834935794 370 1564571 SGTC_3085 9117376 49.47 µM 1.63386597420955 0.0445917481694836 no 216 0.0511434978358386 351 16480349 SGTC_3296 9122258 64.045 µM 1.62894173870046 0.0450701827224217 no 217 0.0516626765613302 368 4730474 SGTC_2705 st078069 42.8 µM 1.62539792662503 0.0454170461556971 no 218 0.0520388987066765 325 1530061 SGTC_738 1315-0003 72.4 µM 1.62302524806535 0.0456504782506761 no 219 0.052292003853047 369 6251474 SGTC_1605 st000082 49.1 µM 1.62217671312643 0.0457341937482102 no 220 0.0523827581485844 332 1114022 SGTC_3188 9110789 49.47 µM 1.61610116864594 0.0463372106578996 no 221 0.0530362208109099 370 849217 SGTC_2044 5102272 200 µM 1.61410064651664 0.0465371600709695 no 222 0.0532527985931673 311 592666 SGTC_2330 7979373 200 µM 1.60159475001967 0.0478028494970846 no 223 0.0546226262568279 393 1863007 SGTC_2142 5622915 118.518 µM 1.59679814857698 0.0482955542534206 no 224 0.0551553543934589 326 5322196 SGTC_1666 st014829 29 µM 1.59351404770141 0.0486352323846909 no 225 0.0555224597417971 400 3858230 SGTC_1433 4060-0023 7.6 µM 1.59260692534546 0.048729392907721 no 226 0.0556241994839992 365 3840627 SGTC_2237 6667747 47.222 µM 1.5923656952015 0.0487544574330922 no 227 0.0556512797854086 334 729940 YDL015C TSC13 SGTC_2491 paeonol 100 µM 1.59164746673296 0.048829144510789 no 228 0.0557319691472129 316 11092 Increases levels of cortical cytochrome oxidase. SGTC_691 1548-0686 185 µM 1.59118191299433 0.0488776052935505 no 229 0.0557843210694677 409 46495133 SGTC_1392 3455-1037 33.9 µM 1.58828688092726 0.0491798203724764 no 230 0.0561107413451728 366 981132 SGTC_2819 7996655 46.38 µM 1.58516779553323 0.0495070926999288 no 231 0.0564641077010006 332 6456960 SGTC_2910 7948405 25.97 µM 1.58457129175794 0.0495698788560166 no 232 0.0565318859494809 334 2971328 SGTC_2957 9076800 11.52 µM 1.58441127019879 0.0495867330399372 no 233 0.0565500794371468 346 16459615 SGTC_2163 5671233 125 µM 1.5836036366594 0.0496718664012499 no 234 0.0566419729205163 411 701023 SGTC_345 1362-0200 395 µM 1.58092554573065 0.0499550011235012 no 235 0.0569475312762492 357 1419823 SGTC_1844 rapamycin 4 nM 1.57454586028875 0.0506346637626613 no 236 0.0576806539815664 540 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1795 st049545 62.3 µM 1.57112069193298 0.0510025927390182 no 237 0.05807730856477 365 5291882 SGTC_151 3013-0144 2.285 µM 1.56603795109032 0.0515524952463632 no 238 0.0586698663677051 408 906558 YHR107C CDC12 SGTC_1262 0737-0114 49.6 µM 1.56462875888092 0.0517057877952179 no 239 0.0588349907874403 455 765919 SGTC_1271 0832-2808 169 µM 1.55911465604163 0.0523091000434046 no 240 0.0594846227019437 405 3663794 SGTC_545 4218-0007 221 µM 1.55857990608595 0.0523679045264564 no 241 0.0595479209926716 375 2840508 SGTC_1407 3909-7909 12.3 µM 1.55802057434258 0.0524294683264323 no 242 0.0596141855001598 402 4411780 SGTC_2697 mebhydrolin 72.4 µM 1.55718477378742 0.0525215691957623 no 243 0.0597133111739608 460 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2479 5617353 43.85 µM 1.55647088463127 0.0526003377112142 no 244 0.0597980804154678 409 2731746 SGTC_430 0958-0115 16.4 µM 1.55378696947788 0.0528973124502139 no 245 0.0601176198807608 412 6833180 SGTC_796 1234-0020 70.7 µM 1.5531312823253 0.0529700658844515 no 246 0.0601958870043925 406 46495034 SGTC_986 1493-0483 84 µM 1.55266565516348 0.0530217789007835 no 247 0.0602515157393975 356 40079 SGTC_2376 9072922 81.32 µM 1.55095590673931 0.0532120087502941 no 248 0.0604561255508484 422 17087968 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.54767869837881 0.0535781492992561 no 249 0.0608498366033007 417 5357218 A potent inhibitor of glutathione S-transferases. SGTC_260 nsc-65238 3.989 µM 1.54745065928509 0.0536037006688678 no 250 0.060877306763453 357 3246252 SGTC_3208 9114115 49.47 µM 1.54657039498441 0.0537024232587814 no 251 0.060983436569505 399 650895 SGTC_431 k089-0097 107 µM 1.54305991411559 0.0540975604953847 no 252 0.061408119801518 485 5499420 SGTC_2300 7976697 71.57 µM 1.54271722363338 0.0541362564530453 no 253 0.0614497005199722 333 2236109 SGTC_1098 clofazimine 15.1 µM 1.52912601285623 0.0556886888052776 no 254 0.0631166038898919 453 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3062 9077494 49.47 µM 1.52684805584588 0.0559522888522128 no 255 0.0633993993382494 397 16459633 SGTC_2384 9036245 200 µM 1.5208496496538 0.0566511201445093 no 256 0.0641487858325385 423 6462766 SGTC_1994 st072947 40.9 µM 1.5202719504157 0.0567187851571781 no 257 0.0642213203314454 412 5286565 YDL195W SEC31 SGTC_2525 harmine 47.85 µM 1.51585289094322 0.0572384909275498 no 258 0.0647782772743186 326 5280953 A monoamine oxidase inhibitor SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.5152239137714 0.0573127658141995 no 259 0.0648578545146827 438 2333 A French combination drug. SGTC_1276 0871-0068 94.2 µM 1.51299242457726 0.0575768907189262 no 260 0.0651407915555972 379 3414906 SGTC_2569 tetrandrine 100 µM 1.51198720940448 0.0576961829521843 no 261 0.0652685582240379 372 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2899 9053889 58.44 µM 1.50838977517149 0.0581246954441179 no 262 0.0657273991913295 368 6470052 SGTC_1070 indatraline 8.81 µM 1.50586713865869 0.0584266709053592 no 263 0.0660506419384148 438 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1988 st071872 53.4 µM 1.50417885890734 0.0586294558547872 no 264 0.0662676598505435 358 16414116 SGTC_2338 7999974 200 µM 1.50170027370904 0.0589281675676426 no 265 0.0665872665932015 450 315925 SGTC_658 3253-0951 102 µM 1.50133616638945 0.0589721491131895 no 266 0.0666343175710681 539 1184878 SGTC_3214 9129694 49.47 µM 1.49677885135323 0.0595248209919617 no 267 0.0672254054844007 397 17158655 SGTC_1506 4226-2149 212 µM 1.49540427162654 0.0596923126480969 no 268 0.067404483203078 491 991114 SGTC_2301 7769476 200 µM 1.49251556307498 0.0600455032174973 no 269 0.0677820202083361 377 977820 SGTC_1251 0490-5699 265 µM 1.49105238863403 0.0602250228323995 no 270 0.0679738705293238 487 3883818 SGTC_480 am 92016 50 µM 1.48945940264107 0.0604209466821396 no 271 0.068183218080608 371 2129 K+ channel blocker. SGTC_2002 4023503 131 µM 1.48667650014676 0.0607644165815593 no 272 0.0685501361097975 538 4736863 YCR052W RSC6 SGTC_2858 9025781 8.96 µM 1.48428200288364 0.0610611694206829 no 273 0.0688670613873267 570 4894980 YPL153C RAD53 SGTC_68 0986-0284 82.829 µM 1.48336537296267 0.0611750677953801 no 274 0.0689886810864072 420 423278 YIL048W NEO1 SGTC_56 0957-0365 83.25 µM 1.48260770505896 0.0612693391860869 no 275 0.0690893344052779 442 6752360 SGTC_3108 9121785 49.47 µM 1.48183347316927 0.0613657887376578 no 276 0.0691923050543435 414 17140271 SGTC_1108 betulinic acid 729.144 nM 1.48021277036202 0.0615680709643141 no 277 0.0694082367253254 431 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2630 antimycin a 100 µM 1.47759185167839 0.0618962930158722 no 278 0.0697585283292638 478 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3186 9110464 49.47 µM 1.47478211909282 0.0622496756230036 no 279 0.0701355649949832 429 17018021 SGTC_2619 obliquin 87.91 µM 1.47457081351107 0.0622763152105746 no 280 0.0701639832428495 557 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2319 6033012 152.6 µM 1.47437135917508 0.0623014688519433 no 281 0.0701908157550583 361 847246 SGTC_2229 7354935 190 µM 1.47433063571671 0.0623066055541108 no 282 0.070196295235761 349 318112 SGTC_707 0865-0008 204 µM 1.47064782478808 0.0627725084089825 no 283 0.0706931915789213 427 723043 SGTC_2129 girgensonine 121.053 µM 1.47047340879269 0.0627946404723678 no 284 0.0707167911946308 486 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2972 9093619 59.92 µM 1.47041141250812 0.0628025087940135 no 285 0.0707251811523624 434 25236256 SGTC_2545 solidagenone 89.61 µM 1.46807702690699 0.0630993391598507 no 286 0.0710416505196032 247 6708572 An anti ulcer agent SGTC_626 0214-0009 33 µM 1.46592062317662 0.0633745078943877 no 287 0.0713349564182707 451 3437874 SGTC_1972 st070201 17.4 µM 1.46240789779072 0.0638247496049322 no 288 0.0718147332406498 427 2829099 SGTC_1420 4'-methoxyflavone 42 µM 1.45786922503141 0.0644101709832902 no 289 0.0724382963847937 412 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2703 st077852 53.4 µM 1.45772633814046 0.0644286687874384 no 290 0.072457994591997 436 6281836 SGTC_864 0469-0573 172 µM 1.45583905389728 0.0646733796859349 no 291 0.0727185584292938 434 689425 SGTC_3233 9132340 49.47 µM 1.45575097495587 0.0646848178700619 no 292 0.0727307363602905 443 17682950 SGTC_2304 7443016 91.4 µM 1.45541737860523 0.0647281538938513 no 293 0.072776874067304 397 939854 SGTC_155 k072-0202 43.6 µM 1.45290485259566 0.0650552697477897 no 294 0.0731250867287662 404 5857737 SGTC_79 0052-0007 94.094 µM 1.45267279919278 0.065085546317912 no 295 0.0731573113666925 447 2801472 SGTC_844 0330-0132 15.3 µM 1.45159888922218 0.0652258043816232 no 296 0.0733065838988876 440 2828079 SGTC_3075 9116269 49.47 µM 1.44602301339547 0.0659578148722588 no 297 0.074085373551569 443 17015205 YNL244C SUI1 SGTC_288 1315-0019 35.1 µM 1.4414953234128 0.0665568877694706 no 298 0.0747223987901059 467 6811474 SGTC_1370 2001-0092 44.6 µM 1.43939323615562 0.0668364492708759 no 299 0.0750195698300758 539 790957 SGTC_2348 9022543 33.42 µM 1.43873381116376 0.0669243346883821 no 300 0.0751129779057158 483 3162678 YDL140C RPO21 SGTC_2379 9035213 200 µM 1.43740865396527 0.0671012164222711 no 301 0.0753009556325897 496 646551 SGTC_2078 5212016 200 µM 1.43469729677838 0.0674642542437951 no 302 0.0756866874342499 391 1899708 SGTC_1330 1469-0054 61.8 µM 1.43096142731799 0.067966953721383 no 303 0.0762206351622348 457 7102664 SGTC_2007 4011539 71.82 µM 1.42979715968778 0.0681242075616303 no 304 0.0763876222664143 484 45595301 SGTC_2925 9010536 32.5 µM 1.4292202524392 0.0682022325376692 no 305 0.0764704692567712 546 2994177 SGTC_2227 7312221 64.1025 µM 1.4235016610188 0.0689793897473519 no 306 0.0772953904726231 404 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3087 9117406 49.47 µM 1.42349914838805 0.0689797327080682 no 307 0.0772957544058315 438 42546093 SGTC_2021 4019055 173 µM 1.42277373528253 0.0690788027091311 no 308 0.0774008787748976 651 44827708 YER133W GLC7 SGTC_2259 7964009 200 µM 1.4049311724798 0.0715502384233595 no 309 0.0800208729873876 433 313134 SGTC_1634 st006576 41 µM 1.40253589546051 0.0718871183039559 no 310 0.0803776396458868 469 3915356 SGTC_170 4197-0004 226 µM 1.40052937948312 0.0721702566279661 no 311 0.0806774259538631 419 218692 SGTC_1732 st034308 51.822 µM 1.39830229999821 0.0724855185507752 no 312 0.0810111537492041 465 830119 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.39253791653924 0.0733064145070943 no 313 0.0818797840640945 467 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3235 9132602 49.47 µM 1.39246215038159 0.073317251390638 no 314 0.0818912477583407 521 4912240 SGTC_2803 7707263 71.43 µM 1.39221199933215 0.0733530393626194 no 315 0.0819291051079156 452 2199229 SGTC_482 fipronil 114 µM 1.39062418360343 0.0735805125882503 no 316 0.0821697094878819 383 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_160 3453-0671 289.699 µM 1.38876074062421 0.0738481601167036 no 317 0.0824527585229979 501 5322268 SGTC_3175 9106517 49.47 µM 1.38846087315023 0.0738912996884852 no 318 0.0824983755984196 454 41468073 SGTC_1860 st056228 74.6 µM 1.38547001593139 0.074322625267167 no 319 0.0829543973729104 467 688679 SGTC_1301 naphtanilide LB 4.81 µM 1.37789859023638 0.0754231285242482 no 320 0.0841173001414635 519 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3285 9112818 20.8695 µM 1.37736066916508 0.0755017851251774 no 321 0.0842003832671653 540 17017947 YPR165W RHO1 SGTC_2490 carminic acid 95.39 µM 1.36824254320221 0.0768445959467976 no 322 0.0856180844898763 418 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2663 amphotericin b 100 µM 1.36653248363076 0.0770984431136398 no 323 0.0858859461765655 471 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3055 9094636 49.47 µM 1.36466057576644 0.0773770456077011 no 324 0.086179878071362 465 25236176 SGTC_793 0488-0545 106 µM 1.36432828158831 0.0774265819152317 no 325 0.0862321343267008 508 292548 SGTC_2428 5615643 7.78 µM 1.36260016421284 0.0776845870971986 no 326 0.086504278534845 499 2253075 SGTC_452 diindolylmethane 8 µM 1.36244073664755 0.0777084222240454 no 327 0.0865294175282228 439 3071 Inhibits expression of several cancer promoting factors. SGTC_3119 9125183 49.47 µM 1.36230687439334 0.0777284395108705 no 328 0.0865505295280713 363 22695334 SGTC_2722 naftopidil 47.16 µM 1.36133990958455 0.077873152272784 no 329 0.086703148147689 519 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3271 9137798 49.47 µM 1.35971856691102 0.0781162557680034 no 330 0.0869595001609388 429 6498326 SGTC_1323 1348-1351 11.2 µM 1.35904311557956 0.0782177023882965 no 331 0.0870664633185503 467 6989654 SGTC_2009 4012297 12.05 µM 1.34533508567766 0.0802981759611793 no 332 0.0892585240096899 497 45595307 SGTC_1348 1493-0373 93.8 µM 1.3449213059242 0.0803616194776847 no 333 0.0893253244970816 498 3010129 SGTC_1127 asiatic acid 681.4 nM 1.34399545942444 0.0805037137199118 no 334 0.0894749275957229 509 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2647 atorvastatin 60.16 µM 1.34371504732923 0.0805467873774617 no 335 0.0895202747891725 495 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2492 derrusnin 100 µM 1.34064809025667 0.0810190348617021 no 336 0.0900173678563969 454 1715307 Part of coumarin class of compounds. SGTC_1739 st037196 92.5 µM 1.33401983018457 0.0820467830301656 no 337 0.0910986788487028 548 612214 SGTC_2281 7943571 200 µM 1.32621875004825 0.0832689307518629 no 338 0.0923836251870632 542 1244024 SGTC_171 k064-0041 9.68 µM 1.32077331194283 0.0841301115427162 no 339 0.0932884804637989 430 53325 SGTC_216 k038-0035 28.382 µM 1.31834109852453 0.0845169123578112 no 340 0.0936947443985684 479 4444231 YPR107C YTH1 SGTC_1999 st074831 12.5 µM 1.31677977911629 0.0847659149217224 no 341 0.0939562263610151 555 17112523 SGTC_1721 st082152 9.2685 µM 1.31252513669174 0.0854472460123454 no 342 0.0946715052166409 492 5296051 SGTC_801 0866-0028 10.1 µM 1.31067273755673 0.0857451644130825 no 343 0.0949841765518176 573 6849771 SGTC_300 r073-0011 5.04 µM 1.30961489300291 0.085915644311941 no 344 0.0951630738286951 607 2735780 SGTC_2896 9052656 71.43 µM 1.30902607204868 0.0860106472257438 no 345 0.0952627596615308 658 6469436 SGTC_1057 3448-5381 134 µM 1.30828194552599 0.0861308202188405 no 346 0.095388848270255 551 5497911 SGTC_2516 gossypol 71.55 µM 1.3075938695765 0.0862420530338442 no 347 0.0955055486647078 579 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2764 methyldopa 94.69 µM 1.3038122389701 0.0868553015285676 no 348 0.0961488043096478 563 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1991 st073000 8.92 µM 1.3033181459556 0.0869356662206246 no 349 0.0962330842731883 607 4301969 YIL048W NEO1 SGTC_676 falcarinol 140 µM 1.30190245126584 0.0871662378768029 no 350 0.0964748672095309 564 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_421 streptovitacin 30 mM 1.30066598045582 0.0873679929888235 no 351 0.0966864058513609 581 91467 include heat shock SGTC_80 0159-0065 512.242 µM 1.29843199960649 0.0877333954843965 no 352 0.0970694645465222 398 1548079 SGTC_1283 0922-0125 16.4 µM 1.29714178567572 0.0879449488462616 no 353 0.0972912031943477 589 3360884 SGTC_3166 9102297 49.47 µM 1.29711087287747 0.0879500222078692 no 354 0.0972965204823041 580 25237072 SGTC_130 0136-0219 337.655 µM 1.29701888353689 0.0879651206501224 no 355 0.0973123447631838 562 234244 SGTC_2253 7938677 135.83 µM 1.29272086972301 0.0886727211752798 no 356 0.0980538085185023 535 2301972 SGTC_1763 st044482 94.5 µM 1.29150517465785 0.0888736333557026 no 357 0.09826428096294 566 88505 SGTC_1745 st081495 74 µM 1.29119604806537 0.0889247752539023 no 358 0.0983178525666476 612 13842402 YBL026W LSM2 SGTC_1310 1188-0297 994 nM 1.29090189861223 0.0889734596738872 no 359 0.0983688484915478 556 1588352 SGTC_145 3737-0113 38.366 µM 1.29002412004864 0.0891188579836491 no 360 0.0985211418202491 651 6849351 SGTC_1270 0831-1170 17.3 µM 1.28997604400744 0.0891268265718713 no 361 0.0985294879281471 599 6764716 SGTC_1677 st019204 53.9 µM 1.28931871803522 0.0892358313318102 no 362 0.098643653107688 525 3945625 SGTC_788 1182-0090 188 µM 1.2870433509042 0.089613922821488 no 363 0.0990395893186681 680 5715185 SGTC_1976 st070609 63.5 µM 1.28644856371231 0.0897129530765661 no 364 0.0991432795156216 579 682556 SGTC_2267 7931562 200 µM 1.28520515447649 0.0899202397073715 no 365 0.0993603014487555 499 934880 SGTC_3323 9138564 53.9225 µM 1.28443404058479 0.0900489694824723 no 366 0.0994950643390378 611 43912313 YNL103W MET4 SGTC_542 3381-0244 89.3 µM 1.28207061546813 0.0904443726898023 no 367 0.0999089378984428 629 1112843 SGTC_2515 chrysin 20.77 µM 1.28051541245651 0.0907052619245824 no 368 0.100181963892736 570 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3006 9075424 71.4286 µM 1.2793357564782 0.0909035243814134 no 369 0.1003894231322 533 7465181 SGTC_319 1348-1596 45.5 µM 1.27804560594921 0.0911207253353923 no 370 0.100616673138644 589 5380505 SGTC_3040 9091894 49.47 µM 1.27615240797187 0.0914401476858744 no 371 0.100950824261367 492 25236966 SGTC_2924 9010168 62.78 µM 1.27340213359897 0.0919056543885121 no 372 0.101437690332044 583 2993929 SGTC_3209 9113616 49.47 µM 1.27265125056798 0.0920330520407907 no 373 0.101570911796623 607 16649353 SGTC_2695 st077686 51.995 µM 1.27198765457936 0.0921457490460135 no 374 0.101688752836533 523 2876092 SGTC_2205 7238770 200 µM 1.26943125028482 0.0925808523141149 no 375 0.102143648169759 525 279867 SGTC_1567 st069303 68.4 µM 1.26885904410067 0.0926784503640036 no 376 0.102245670953774 595 5581319 SGTC_656 4090-1979 187 µM 1.26689717262491 0.0930136536783225 no 377 0.102596029919977 611 22330961 SGTC_763 3453-1109 128 µM 1.26675445295367 0.0930380735354183 no 378 0.102621551388802 583 1560353 SGTC_376 3970-0862 59.1 µM 1.259196995449 0.0943379608206869 no 379 0.10397959326833 589 3135186 SGTC_1561 5-methoxyflavone 52.9 µM 1.25452369528251 0.0951484451172664 no 380 0.104825859331208 500 94525 SGTC_1915 st067105 30.6 µM 1.2534844049974 0.09532938282211 no 381 0.105014735527566 583 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1688 st021091 57.6 µM 1.2521018847968 0.0955704683965505 no 382 0.105266370502474 565 3656366 SGTC_663 1486-0733 13.9 µM 1.24770431672291 0.0963403048007186 no 383 0.106069679943433 655 722445 YPR165W RHO1 SGTC_561 1550-0330 72.9 µM 1.24743818054023 0.0963870403146224 no 384 0.106118437129884 544 6812934 SGTC_2175 5807670 165.306 µM 1.24510815262687 0.0967969223551059 no 385 0.106545998876951 564 241186 SGTC_1794 st048918 76.9 µM 1.24349989574027 0.0970805812221891 no 386 0.10684183967521 483 672303 SGTC_3115 9123671 49.47 µM 1.23794491935377 0.0980650417961721 no 387 0.107868242499789 590 3286988 SGTC_3324 9138759 60.749 µM 1.23683616252576 0.0982624098543384 no 388 0.108073956840425 576 45595710 SGTC_2966 9084041 48.03 µM 1.23635623802841 0.0983479306255747 no 389 0.108163087661032 562 17741380 SGTC_2950 9072895 21.46 µM 1.23568942534211 0.0984668446455975 no 390 0.108287014877919 609 17332245 SGTC_2778 tioconazole 65.09 nM 1.23407012666238 0.0987560555432406 no 391 0.108588387038318 611 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3345 9148410 3.559 µM 1.23399649087535 0.0987692218452244 no 392 0.10860210592547 543 4903596 SGTC_1912 st060209 90.8 µM 1.23297491362341 0.0989520155053229 no 393 0.108792561895239 575 688787 SGTC_2701 st077767 14.721 µM 1.23292632893517 0.0989607150596961 no 394 0.108801625675441 649 5721188 SGTC_553 k007-0256 45.7 µM 1.23151518715273 0.0992136377192095 no 395 0.109065120029753 600 6287000 SGTC_1588 farnesol 29.9 µM 1.22969212294882 0.0995410896848435 no 396 0.109406208829432 596 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_465 cgp-37157 41 µM 1.22953235930149 0.09956982342997 no 397 0.109436136510923 463 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1404 3909-7820 48.3 µM 1.2294013930975 0.0995933824299097 no 398 0.109460674104481 584 23741373 SGTC_1920 st075728 45.7 µM 1.22553687459258 0.100290390136372 no 399 0.110186502719717 592 3400306 SGTC_3226 9131256 49.47 µM 1.22279760826882 0.100786598186346 no 400 0.110703074526007 471 17178073 SGTC_2249 haloperidol 116.36 µM 1.22164472582537 0.100995973069627 no 401 0.110921003621862 726 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1548 st061468 90.8 µM 1.22057187826874 0.10119109747504 no 402 0.111124079645195 617 390799 SGTC_1272 0839-0021 27 µM 1.2156604125152 0.102087879389177 no 403 0.112057155203314 633 5027250 SGTC_3042 9091578 49.47 µM 1.21510876924746 0.102188963715422 no 404 0.112162304709331 564 25236497 SGTC_1613 st002381 52.1 µM 1.20767304619546 0.103558613215683 no 405 0.113586524862537 597 551167 SGTC_2563 tomatine 8.54 µM 1.20305063084237 0.104416742871541 no 406 0.114478364145487 687 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3339 9145883 14.936 µM 1.20017527419406 0.104953132100629 no 407 0.115035637996707 582 2030670 SGTC_2261 9010538 184.68 µM 1.19769343473327 0.105417713412783 no 408 0.115518193075975 535 6457250 SGTC_1558 st069300 45.6 µM 1.19648011165177 0.105645378795759 no 409 0.115754627606882 550 24208000 SGTC_834 0312-0008 75.7 µM 1.19511657578787 0.105901653791905 no 410 0.116020743303908 658 6385573 YIL048W NEO1 SGTC_1471 k673-0312 37 µM 1.19455216846412 0.106007864872693 no 411 0.116131023358383 594 24099884 SGTC_3305 9127027 53.8275 µM 1.19309813822872 0.106281841144613 no 412 0.116415470291229 626 41905295 SGTC_1152 3909-8331 15.9 µM 1.19122563780473 0.106635420709319 no 413 0.116782508695562 591 16001939 SGTC_1222 0366-0074 1.18 µM 1.190886425351 0.106699564076574 no 414 0.116849087138922 660 286520 SGTC_2511 berberine 10.47 µM 1.19079411712356 0.106717023916479 no 415 0.11686720946144 627 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_83 0170-0301 39.027 µM 1.18595742149906 0.107634757560678 no 416 0.117819557379726 521 3089716 SGTC_3098 9119039 49.47 µM 1.18351483031871 0.108100379476586 no 417 0.118302586255985 628 17161528 SGTC_1064 honokiol 6.76 µM 1.18270232147236 0.108255585910559 no 418 0.11846357192176 651 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1322 1348-1070 12 µM 1.18135061081035 0.108514146572418 no 419 0.118731734770363 593 6758089 SGTC_797 k781-0471 270 µM 1.18029738788373 0.108715919021062 no 420 0.118940978349177 664 23738129 SGTC_1135 dihydrocapsaicin 536.708 nM 1.17887943546545 0.108987990895776 no 421 0.119223093758497 620 107982 A Capsaicinoid. SGTC_2681 menadione 3.18 µM 1.17210729042224 0.110294158023681 no 422 0.12057699164477 637 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_786 4544-0069 423 µM 1.16538565106905 0.111601647088836 no 423 0.121931461430143 680 748821 YLR208W SEC13 SGTC_2882 9058044 58.44 µM 1.16478173344159 0.111719661444345 no 424 0.122053677345377 613 18076804 SGTC_670 4204-0025 119 µM 1.16349036003985 0.111972314207877 no 425 0.122315303529646 678 719039 SGTC_29 0299-0004 12.984 µM 1.16172304728103 0.112318744621124 no 426 0.122673990405369 543 16871 A napthoquinone isolated from Swertia calycina. SGTC_2275 7947463 200 µM 1.16073141800374 0.112513459883759 no 427 0.122875570433239 610 1225414 SGTC_2908 7930301 100 µM 1.16059038708549 0.112541172137175 no 428 0.12290425828491 735 2223178 SGTC_746 1095-0025 46.6 µM 1.15584884437757 0.113475713411624 no 429 0.123871495015783 707 6749286 SGTC_510 ag-490 170 µM 1.15302718533565 0.114034472049686 no 430 0.124449613198294 706 5328779 SGTC_2898 9056270 58.44 µM 1.15225419778599 0.114187884253969 no 431 0.124608316135456 581 19154699 SGTC_2041 5107442 45.335 µM 1.15165183120557 0.114307535757999 no 432 0.124732086728432 671 793005 SGTC_236 1509-0011 5.31 µM 1.14976237085913 0.114683429152954 no 433 0.125120878782428 922 3107280 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.14837854540102 0.11495928787088 no 434 0.125406163316564 749 5024745 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.14786774310224 0.115061232923252 no 435 0.125511583142216 648 756377 SGTC_2448 5185112 27.17 µM 1.14532594499866 0.115569476515673 no 436 0.12603708115801 603 5718189 SGTC_792 4534-1957 155 µM 1.14503688307217 0.115627376555188 no 437 0.126096939582132 671 1717904 SGTC_298 1391-0729 10 µM 1.14302844545661 0.11603024214494 no 438 0.126513390472074 641 3237558 SGTC_1628 st004252 77.7 µM 1.13685793821113 0.117274193037797 no 439 0.127798839053088 692 692968 SGTC_2601 securinine 100 µM 1.134477838028 0.117756527707519 no 440 0.128297082406262 650 442872 A GABA receptor antagonist. SGTC_403 arphamenine a 50 µM 1.13203773544223 0.118252477746143 no 441 0.128809285028071 657 5487158 An arginine aminopeptidase inhibitor. SGTC_2616 abietic acid 100 µM 1.13092509891601 0.118479110320935 no 442 0.129043309129883 735 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1257 0669-0121 16 µM 1.13035474381973 0.118595404708098 no 443 0.129163387822235 732 4307855 SGTC_1205 4161-2785 76 µM 1.13034030984302 0.118598348816323 no 444 0.129166427658404 611 3498106 SGTC_2844 9010103 25.97 µM 1.12932398604712 0.118805778940443 no 445 0.129380593015112 664 2480525 SGTC_1451 4152-0210 104 µM 1.12622577435278 0.119439700101353 no 446 0.130034983232733 700 659563 SGTC_1426 4048-4480 71.7 µM 1.12567818331492 0.119551989726005 no 447 0.130150880742943 695 14224343 SGTC_988 1497-1057 103 µM 1.1251406687387 0.119662285466323 no 448 0.130264715074572 702 3533044 SGTC_82 0054-0107 293.755 µM 1.12012994693667 0.12069391812729 no 449 0.131329195374628 677 3104697 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.11823982611032 0.121084687374976 no 450 0.131732289515393 720 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2736 butenafine 14.65 µM 1.11418522012437 0.121925949049802 no 451 0.132599867350482 723 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_168 3970-0862 530.542 µM 1.11205820358404 0.122368906800054 no 452 0.133056562970979 845 3135186 SGTC_1574 spiramycin 23.7 µM 1.1111006577715 0.122568686908526 no 453 0.133262512395445 692 6419898 An antibiotic and protein synthesis inhibitor. SGTC_783 0848-0141 92.7 µM 1.11106009183287 0.122577155540305 no 454 0.133271242177738 657 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2970 9090938 41.86 µM 1.10825555739421 0.123163631644706 no 455 0.133875731573302 778 17217104 SGTC_1791 st048313 56.1 µM 1.10682592141527 0.123463348543505 no 456 0.134184599378986 642 1204976 SGTC_393 acivicin 6.25 µM 1.10654401313328 0.123522509628391 no 457 0.134245562398081 638 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2598 perillyl alcohol 100 µM 1.10539912982747 0.123762978124579 no 458 0.134493340331433 724 10819 An apoptosis inducer. SGTC_1100 amiodarone 5.07 µM 1.10524539122912 0.123795293947197 no 459 0.134526636640903 739 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2038 4100038 30.985 µM 1.10337468973429 0.124188988310754 no 460 0.134932241704525 721 3596803 SGTC_1630 st005209 31.3 µM 1.10291501853547 0.12428586130409 no 461 0.135032035761564 792 3367314 SGTC_2920 7982904 15.77 µM 1.10211193867941 0.124455232449115 no 462 0.135206504860671 621 6456808 SGTC_1495 4469-0029 237 µM 1.10199781714165 0.124479313999423 no 463 0.13523131030085 811 793680 SGTC_2412 st077135 33.4 µM 1.10006784030837 0.124887064841666 no 464 0.135651282338954 701 13258915 SGTC_215 1287-0124 461.5 µM 1.09911026816426 0.125089719396583 no 465 0.135859985820339 669 5560863 SGTC_1814 st052110 31.539 µM 1.09572477848218 0.125808044108774 no 466 0.136599617839687 671 674163 SGTC_1803 st050068 52.4 µM 1.09457344179922 0.126052986178055 no 467 0.136851778032286 857 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1149 3909-7961 23.3 µM 1.09398715477859 0.12617784397245 no 468 0.136980305964235 706 735261 SGTC_3321 9137793 26.8275 µM 1.09187625196033 0.126628103261323 no 469 0.137443748621103 719 4904192 SGTC_1531 st059297 52.4 µM 1.09166200795123 0.126673864358215 no 470 0.137490845048443 727 7566702 SGTC_2700 st077718 96.8 µM 1.08912997817592 0.127215561533712 no 471 0.138048285870669 654 904970 SGTC_719 2810-4230 27.3 µM 1.08886973105478 0.127271329458591 no 472 0.138105667991509 682 721079 SGTC_3253 9135987 49.47 µM 1.08508182681034 0.128084958728815 no 473 0.138942707756781 652 4182430 SGTC_1990 st072050 59.8 µM 1.08257977970209 0.128624367530152 no 474 0.139497493186796 732 17233948 SGTC_1383 3049-0032 20.7 µM 1.07946005975565 0.129299143971296 no 475 0.140191344726412 716 712864 SGTC_2892 9047358 58.44 µM 1.07889964321781 0.129420618138835 no 476 0.140316233960583 662 6466771 SGTC_2095 5432005 200 µM 1.07875354466992 0.129452299002197 no 477 0.140348804540899 685 783734 SGTC_3275 9138069 49.47 µM 1.07483146260427 0.130304795085509 no 478 0.14122509573762 703 17617007 SGTC_2256 7954252 200 µM 1.07409864476248 0.130464508586486 no 479 0.141389235956376 622 2972920 SGTC_593 1203-0218 61.7 µM 1.0713837752058 0.13105737866256 no 480 0.141998452542724 772 3666956 SGTC_448 monastrol 171 µM 1.07023044515758 0.131309803999961 no 481 0.142257796777834 726 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_629 3448-6466 76.7 µM 1.07020999411266 0.131314283076387 no 482 0.142262398404137 743 573744 SGTC_1809 st050081 57.6 µM 1.06747130674972 0.131915048708266 no 483 0.142879531899965 738 5036894 SGTC_2435 5706476 10.6 µM 1.06640548295405 0.132149362291446 no 484 0.143120192104845 770 5725375 SGTC_85 0868-0259 160.055 µM 1.06638053460494 0.132154850438879 no 485 0.143125828654384 710 83173 SGTC_2221 6807166 181.081 µM 1.06468796635102 0.13252754926863 no 486 0.143508578715698 663 674925 SGTC_2653 dihydrofissinolide 100 µM 1.06393138146429 0.132694381145922 no 487 0.143679892807484 735 6857746 SGTC_927 2425-1185 123 µM 1.06194305677513 0.133133509048244 no 488 0.144130768385267 727 730375 SGTC_3182 9108849 49.47 µM 1.06155493637521 0.133219343221029 no 489 0.144218890331012 759 17133045 SGTC_3034 9090421 49.47 µM 1.05801697617077 0.134003531120751 no 490 0.145023851485598 711 17173761 SGTC_1196 1588-0294 184 µM 1.05677070866752 0.134280519892674 no 491 0.145308122759302 693 6144269 SGTC_2135 5326629 150.42 µM 1.0550409623369 0.134665615300901 no 492 0.14570329548969 675 5020077 SGTC_1316 1272-0050 65.9 µM 1.05283216127211 0.135158464120763 no 493 0.146208961045493 734 7340392 SGTC_2564 betulinic acid 100 µM 1.04049869975358 0.13793314571077 no 494 0.149054133913319 822 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2353 9059630 146.67 µM 1.04047398680296 0.137938744154876 no 495 0.149059871754129 761 4779114 SGTC_967 1306-0166 352 µM 1.04019471231668 0.138002021456876 no 496 0.149124723822673 773 4437607 SGTC_1131 3454-3128 32.3 µM 1.03998856500183 0.138048742489525 no 497 0.1491726066626 806 710982 SGTC_2180 6301957 200 µM 1.0398564996005 0.138078679335761 no 498 0.149203287531417 790 845462 SGTC_1192 1488-0095 21.4 µM 1.03963387797559 0.138129153666826 no 499 0.14925501557271 740 915875 SGTC_706 4262-0057 46.9 µM 1.03952386716905 0.138154100730148 no 500 0.14928058194621 735 883298 SGTC_1687 st020778 55.3625 µM 1.03845142588365 0.138397458344923 no 501 0.149529969146407 872 4259299 SGTC_2374 9071832 200 µM 1.03835318339469 0.138419766059617 no 502 0.149552828504848 735 17381698 SGTC_524 r073-0010 27.8 µM 1.03784965342044 0.138534140014771 no 503 0.149670027983916 745 2772106 SGTC_1887 st057648 70.8 µM 1.03585943253811 0.138986837456486 no 504 0.150133862904929 773 688672 SGTC_2719 novobiocin 32.65 µM 1.03498295818181 0.139186520179173 no 505 0.15033843498644 713 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_41 0478-0632 82.643 µM 1.03498134537096 0.139186887797588 no 506 0.150338811593079 852 3750424 SGTC_3033 9090887 49.47 µM 1.03174490674155 0.13992592153813 no 507 0.151095817182485 781 19325384 SGTC_1678 st019265 80.2 µM 1.0311234451701 0.140068135584325 no 508 0.151241467303644 791 5367020 SGTC_534 k292-0788 63.4 µM 1.03055588528007 0.140198100644888 no 509 0.151374566213747 863 4146317 SGTC_1708 st033234 31.827 µM 1.02383044744448 0.141744389395024 no 510 0.152957683230755 837 674664 SGTC_617 3770-0098 35 µM 1.02188746741921 0.142193254933572 no 511 0.153417082371396 734 5962639 SGTC_2331 7980721 200 µM 1.02163528395844 0.14225158458496 no 512 0.153476775693347 790 2981221 SGTC_326 k292-0812 17.5 µM 1.02128381646184 0.142332905486478 no 513 0.153559995792674 772 3579357 SGTC_930 2810-3379 265 µM 1.02118934272357 0.142354769739401 no 514 0.153582370278521 854 1015764 SGTC_2278 7948257 134.34 µM 1.01825831432003 0.143034232592191 no 515 0.154277606565622 796 1247028 SGTC_156 3474-0145 5.642 µM 1.01784496239867 0.143130230693214 no 516 0.154375820316792 789 2265471 SGTC_204 PMA1.184 62.41 µM 1.01519442950009 0.143746832706597 no 517 0.155006577718979 839 2252213 YGL008C PMA1 SGTC_405 ebelactone b 50 µM 1.00650847160252 0.145780021587449 no 518 0.157085519270606 802 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2955 9076254 12.21 µM 1.00546094725595 0.146026523442934 no 519 0.157337472568272 745 16459619 SGTC_980 1473-0395 201 µM 1.00356920872982 0.146472393643207 no 520 0.157793151168765 717 768876 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.00130927715158 0.147006241308393 no 521 0.158338654584347 722 2374 Ca(2+)-ATPase inhibitor. SGTC_1648 st011736 69.8 µM 1.00071647096914 0.14714649147366 no 522 0.158481951037448 785 2855514 SGTC_121 0557-0495 61.343 µM 0.99849808902508 0.147672127284637 no 523 0.159018945329226 1002 3104427 SGTC_398 bronopol 33.3 µM 0.99450218070042 0.148622109320505 no 524 0.159989222137832 813 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2889 9059656 51.95 µM 0.993135138690416 0.148948043998366 no 525 0.160322050946411 848 3949838 SGTC_77 0828-0286 12.516 µM 0.992559811453266 0.14908535810051 no 526 0.160462258997574 794 745345 SGTC_3265 9137266 49.47 µM 0.991413917985243 0.149359101833162 no 527 0.160741753445795 788 17224265 SGTC_3003 9075612 71.4286 µM 0.98884948557168 0.149972936947336 no 528 0.161368394264676 782 6501993 SGTC_3102 9121669 49.47 µM 0.988649921761955 0.150020775966177 no 529 0.161417226102372 780 41905072 SGTC_1546 5-methoxyflavanone 78.7 µM 0.987826858984127 0.150218186358713 no 530 0.161618725498612 854 147795 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.985476205437814 0.150782940100484 no 531 0.162195106850556 851 5393153 SGTC_1833 st055984 71 µM 0.984511997476757 0.151015003162334 no 532 0.162431917713119 802 676288 SGTC_213 1246-0773 967 nM 0.984280726105872 0.151070700276728 no 533 0.162488751736805 844 6251622 SGTC_1800 st050079 29.0735 µM 0.983374966330552 0.151288966103928 no 534 0.162711463183471 913 3645560 SGTC_306 1672-3436 11.6 µM 0.98240902923115 0.151521964188312 no 535 0.16294918991887 836 6797378 SGTC_495 decylubiquinone 155 µM 0.979787965311582 0.152155404326768 no 536 0.163595396938264 755 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_892 0929-0076 29 µM 0.976005766641425 0.153072554394971 no 537 0.164530803330332 840 5751038 SGTC_308 4092-1169 104 µM 0.97592919942193 0.153091159038939 no 538 0.164549775520736 862 2268590 YDL196W YDL196W SGTC_2603 homopterocarpin 100 µM 0.975737946384011 0.153137637101087 no 539 0.164597171302994 816 101795 A weak amylase inhibitor. SGTC_883 0850-0245 24.6 µM 0.975290149394821 0.153246496716325 no 540 0.164708177676447 854 6823229 YPR165W RHO1 SGTC_886 0866-0150 153 µM 0.973710042277992 0.153631030949535 no 541 0.165100264836579 886 271463 SGTC_2468 5987765 72.9 µM 0.971708372005941 0.154119073151342 no 542 0.165597825310093 870 26772094 SGTC_1785 bathophenanthroline 24 µM 0.970766413301304 0.154349093633072 no 543 0.165832305677641 794 72812 An iron chelator. SGTC_3236 9132701 49.47 µM 0.967033093834421 0.155262978742217 no 544 0.166763745066295 826 24282524 SGTC_478 N-arachidonylglycine 10 µM 0.966672450774456 0.155351449903603 no 545 0.166853901655669 733 5283389 SGTC_2561 acetosyringone 100 µM 0.965062934815966 0.155746693824915 no 546 0.16725664521308 952 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2355 9061122 103.12 µM 0.964132027665354 0.155975596257555 no 547 0.167489868627743 834 5302957 SGTC_2655 perillic acid 100 µM 0.963937868839235 0.156023366253569 no 548 0.16753853830981 801 5702197 An apoptosis inducer. SGTC_3133 9127736 49.47 µM 0.960456837171387 0.156881460215511 no 549 0.168412672186915 832 27243420 SGTC_608 k048-0125 159 µM 0.960225735543933 0.156938537779417 no 550 0.168470808549664 865 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3141 9094609 49.47 µM 0.956797066100388 0.157786956548654 no 551 0.169334846698701 772 25236309 YDL196W YDL196W SGTC_576 1073-0113 22.7 µM 0.956267333077464 0.157918306307631 no 552 0.169468594733246 1052 5439563 SGTC_1779 st039427 55 µM 0.954177229982488 0.15843725735565 no 553 0.169996969236515 928 1124498 SGTC_1432 4049-0298 68.4 µM 0.953398772040294 0.158630826024717 no 554 0.170194031680831 856 741646 SGTC_228 caffeine 993.056 µM 0.951863284775602 0.159013089399523 no 555 0.170583160936611 808 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2916 7875993 68.79 µM 0.951666481206586 0.159062127738593 no 556 0.170633076826669 850 1299250 SGTC_466 geldanamycin 89.2 µM 0.951474272033945 0.159110030836056 no 557 0.170681836450782 748 5288382 HSP90 inhibitor. SGTC_1277 0873-0036 22 µM 0.950336342218064 0.159393823588064 no 558 0.170970689173903 885 5965735 SGTC_1515 3460-0031 42.1 µM 0.948594488145379 0.15982887288301 no 559 0.171413447707673 798 2876596 SGTC_1172 0370-0043 85 µM 0.94214388743012 0.161446747364342 no 560 0.173059488842205 864 376585 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.939590949218718 0.162089988864362 no 561 0.173713710290956 1023 688664 SGTC_592 k241-0073 46.5 µM 0.936942823431733 0.162758975051142 no 562 0.174393984846893 921 4230158 SGTC_964 1287-0107 19.4 µM 0.936472475215718 0.162877984913604 no 563 0.17451498891443 890 51516812 YPR165W RHO1 SGTC_2996 9066192 71.4286 µM 0.935237965439999 0.163190615848514 no 564 0.174832838474634 847 6472854 SGTC_322 k048-0136 19.3 µM 0.931849037450489 0.164050841189888 no 565 0.175707274025819 832 6823282 SGTC_660 4031-1742 102 µM 0.930792875829401 0.164319531122994 no 566 0.175980357796744 872 6738706 SGTC_2906 7926292 26.41 µM 0.9263258476728 0.165459106798477 no 567 0.177138333565315 877 2966319 SGTC_1581 himbacine 57.9 µM 0.926021066591599 0.165537044832778 no 568 0.177217516165673 864 5281825 An alkaloid muscarinic receptor antagonist. SGTC_506 n9-isopropylolomoucine 153 µM 0.925927294743233 0.165561028766158 no 569 0.177241882734483 895 6610355 SGTC_776 4476-4378 112 µM 0.925010564533578 0.165795618326621 no 570 0.177480206071633 841 2892008 SGTC_95 0471-0001 561.058 µM 0.924647410505657 0.165888608162187 no 571 0.177574671525633 855 4015405 SGTC_3308 9128332 17.569 µM 0.923856206217027 0.16609132197699 no 572 0.177780593423652 946 17332805 YDL196W YDL196W SGTC_916 4466-0038 42 nM 0.921881367330811 0.166597991803409 no 573 0.178295229571174 981 5722064 YGL116W CDC20 SGTC_1231 0242-0792 125 µM 0.9194692207575 0.167218210348164 no 574 0.178925098819622 881 3707635 SGTC_330 1488-0319 80.1 µM 0.918083974012568 0.167575061196373 no 575 0.17928745215281 876 6846614 SGTC_536 3852-0578 10.6 µM 0.917927453471241 0.167615412985732 no 576 0.179328423848417 918 2869208 SGTC_1906 st060206 94.7 µM 0.917855915837287 0.167633857834307 no 577 0.179347151901314 942 5133468 SGTC_1491 4138-0063 26.5 µM 0.916074918426098 0.168093481251117 no 578 0.179813800956514 878 23883227 SGTC_2926 9010726 65.15 µM 0.914774125316149 0.168429689897127 no 579 0.180155110517771 871 2994293 SGTC_818 4072-2707 53.5 µM 0.914725400709392 0.168442291867364 no 580 0.180167903056345 883 882871 SGTC_446 go6976 132 µM 0.9146824098428 0.168453411385579 no 581 0.180179190687497 871 3501 A protein kinase C inhibitor. SGTC_488 nitrendipine 139 µM 0.91407531111704 0.168610486884002 no 582 0.180338637202566 925 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2586 curcumin 80 µM 0.912681343482685 0.168971506218626 no 583 0.180705079417727 960 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1715 st032160 10.2275 µM 0.912400465466282 0.169044310000347 no 584 0.180778972298313 863 5289825 SGTC_1603 st002045 67.8 µM 0.910512005887589 0.169534323037622 no 585 0.181276276515012 925 5887985 SGTC_2671 danthron 100 µM 0.909876025032108 0.169699550784345 no 586 0.181443947452375 885 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2218 6965428 192.983 µM 0.909846534019337 0.169707215050678 no 587 0.181451724861442 900 675684 SGTC_2216 7189485 200 µM 0.908647604286545 0.170018986649186 no 588 0.181768084887653 929 731273 SGTC_2220 6782180 200 µM 0.907824741355441 0.17023317755278 no 589 0.181985412212829 836 833803 SGTC_1545 lovastatin 49.4 µM 0.907680433494031 0.170270758644124 no 590 0.182023542276 951 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3008 9078912 71.4286 µM 0.906124840856294 0.170676208220891 no 591 0.182434889268279 874 16648731 SGTC_2877 9040724 71.43 µM 0.905346296693253 0.170879359786601 no 592 0.182640978393108 914 6463895 SGTC_3230 9131665 49.47 µM 0.905102406490455 0.170943031761607 no 593 0.182705568679787 831 15943720 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.902605433299289 0.171595785065675 no 594 0.183367670942095 937 688798 SGTC_1830 st055982 50.3 µM 0.902001697399739 0.171753851161806 no 595 0.183527983027928 890 455313 An antimicrobial agent. SGTC_35 0133-0054 64.071 µM 0.898297841480842 0.172725604414411 no 596 0.184513391503139 856 99677 SGTC_245 methotrexate 289.6 µM 0.895730687577492 0.173401181845354 no 597 0.185198308221199 932 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2967 9089538 49.85 µM 0.895199930193544 0.173541066587241 no 598 0.185340111029355 941 728216 SGTC_1390 3413-2614 145 µM 0.895095708727911 0.173568543301014 no 599 0.18536796386472 943 3421432 SGTC_2493 resveratrol 26.09 µM 0.891701467402888 0.174464906392218 no 600 0.18627648340693 855 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2056 5235370 200 µM 0.89004306125442 0.174903931418905 no 601 0.186721382285003 865 5511916 SGTC_2818 7996756 12.99 µM 0.889835509723842 0.1749589252504 no 602 0.186777108191667 863 2241621 SGTC_2696 st077691 74.316 µM 0.888038939070271 0.175435411521021 no 603 0.18725990297221 838 757133 SGTC_1606 st000094 49.2 µM 0.887359164263705 0.17561591562918 no 604 0.187442780784248 985 1242210 SGTC_1815 st051655 58.2 µM 0.886192081127792 0.175926091591566 no 605 0.187757015063797 921 5984156 SGTC_107 0358-0022 2.6945 µM 0.885482062662406 0.176114962993602 no 606 0.187948344890583 828 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_560 2332-1943 155 µM 0.885442041577086 0.176125612788156 no 607 0.187959133019898 919 21177716 SGTC_1141 3253-0389 52.6 µM 0.884795736458387 0.176297653993437 no 608 0.188133404698257 934 5402031 SGTC_861 0443-0273 110 µM 0.882654065793695 0.176868509137876 no 609 0.188711603676459 948 6149169 SGTC_1447 4239-0816 81.9 µM 0.881329899007584 0.177222045157228 no 610 0.189069643859061 865 1341554 SGTC_1497 4476-2978 41.3 µM 0.878086147007173 0.178089970677027 no 611 0.189948485065107 976 1528379 SGTC_1055 3448-0672 86 µM 0.877677134620115 0.178199599397975 no 612 0.190059478251918 895 748378 SGTC_2217 6934799 96.0675 µM 0.877460138969921 0.178257778607591 no 613 0.190118380273854 951 675606 SGTC_81 0411-0046 9.971 µM 0.87559086614905 0.178759449301413 no 614 0.190626246319493 867 12925265 SGTC_2585 alliin 100 µM 0.875424810654486 0.178804057799304 no 615 0.190671402470976 945 87310 A garlic compound which reacts with lipids. SGTC_1690 st023502 41.2 µM 0.875045934427274 0.178905863856446 no 616 0.190774456413112 928 24207482 SGTC_539 4859-0462 2.54 µM 0.874973605008186 0.178925303302186 no 617 0.190794133824889 961 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2988 9073640 71.4286 µM 0.87449301244101 0.179054502388024 no 618 0.190924911944178 889 9102229 SGTC_2543 pimpinellin 60.67 µM 0.873920390849545 0.179208518512888 no 619 0.191080804633984 889 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_131 0141-0277 33.849 µM 0.873517043328389 0.179317055555864 no 620 0.19119066034565 931 1547771 SGTC_1975 st070967 30.8 µM 0.870081598696371 0.180243176243145 no 621 0.192127906505772 1010 261391 SGTC_795 0685-0265 78 µM 0.8698857248619 0.180296069843124 no 622 0.19218142870094 990 302754 SGTC_3195 9113082 49.47 µM 0.869692192629105 0.180348340684497 no 623 0.192234320014813 936 17018038 SGTC_1623 st003709 20.3 µM 0.867233947484522 0.181013111815405 no 624 0.192906919726998 956 16192618 SGTC_603 3794-0023 45.9 µM 0.865963432822689 0.181357291890079 no 625 0.193255107582247 954 3802260 SGTC_2678 equilin 100 µM 0.864993917908085 0.181620207140562 no 626 0.193521063519753 984 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2206 7254556 146.969 µM 0.86457420798621 0.181734098968493 no 627 0.19363626695154 960 4398905 SGTC_897 1000-0139 31.4 µM 0.864564725785868 0.181736672559586 no 628 0.193638870141702 954 6151020 SGTC_950 1165-0508 94.1 µM 0.861686264843889 0.182518977712975 no 629 0.194430092946994 888 6148369 SGTC_1466 k213-0079 57.5 µM 0.861055775418237 0.182690611881536 no 630 0.194603662400774 968 3657981 SGTC_3010 9080089 71.4286 µM 0.860875923189299 0.182739590389147 no 631 0.194653191776026 964 17027233 SGTC_2746 daunorubicin 9.88 µM 0.860595179793876 0.182816060607305 no 632 0.194730520825731 838 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1736 st036774 51 µM 0.858935572786609 0.183268520187684 no 633 0.195188031079212 1009 1272247 SGTC_566 0958-0068 16.5 µM 0.856831328969171 0.183843204407293 no 634 0.195769054379837 903 6815365 SGTC_2399 5884133 200 µM 0.856524224414137 0.183927170644814 no 635 0.195853939712561 943 722445 SGTC_2853 9015042 58.44 µM 0.855447036068134 0.184221876199097 no 636 0.196151856823433 945 6457456 SGTC_1674 st016616 23.6 µM 0.855193840885661 0.184291189936637 no 637 0.196221922679684 943 625830 SGTC_1590 st077108 57.8 µM 0.854531832000786 0.184472495609203 no 638 0.196405189881006 969 5489485 SGTC_2398 5228213 48.84 µM 0.852588043462282 0.185005485629071 no 639 0.196943897699399 1030 80771 YMR134W ERG29 SGTC_1501 4491-0275 38.4 µM 0.852450825563439 0.185043147123565 no 640 0.19698196048079 990 5104718 SGTC_2181 6316240 54.2555 µM 0.851469822572394 0.185312536723681 no 641 0.197254209937824 930 12779990 SGTC_2029 5175081 200 µM 0.850962679032332 0.185451896965914 no 642 0.197395042402628 1030 1380876 SGTC_868 0527-0199 213 µM 0.84904125535256 0.185980483473482 no 643 0.197929168229538 963 2849450 SGTC_8 0354-0001 70 µM 0.848187888805576 0.18621554514545 no 644 0.198166670523598 1054 4993152 SGTC_2036 5160441 105 µM 0.847943063918042 0.18628301666571 no 645 0.198234840016746 1028 134534 YIL048W NEO1 SGTC_445 e6 berbamine 66 µM 0.847552873449912 0.186390580926749 no 646 0.198343514623197 1036 6610268 A calcium/calmodulin antagonist. SGTC_2537 larixol 68.93 µM 0.846034753619661 0.186809448739728 no 647 0.198766678471679 1010 6708759 SGTC_2073 5212005 126 µM 0.845361015407286 0.186995527846818 no 648 0.19895465190336 871 691789 SGTC_1009 4106-0057 9.87 µM 0.843086340805061 0.187624614729713 no 649 0.199590078694201 1034 2928005 SGTC_469 w7 172 µM 0.839276801954896 0.188681110140332 no 650 0.200656998933333 990 45115570 A P450 inhibitor. SGTC_1424 4048-1941 275 µM 0.838600746241852 0.188868982377374 no 651 0.200846695886636 1070 X1424 SGTC_2963 9082507 9 µM 0.838540213948634 0.188885809595764 no 652 0.200863686112619 920 16459611 SGTC_687 k029-0044 34.9 µM 0.837391164367435 0.189205406142804 no 653 0.201186365309394 1036 5829338 SGTC_500 h-89 112 µM 0.836450860020106 0.189467189876789 no 654 0.201450655224014 1031 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3273 9137859 49.47 µM 0.835511398430183 0.189728961459212 no 655 0.201714915937256 1018 2377234 SGTC_1332 1480-0653 17.5 µM 0.835381046384981 0.189765300318735 no 656 0.201751598998486 1000 5749438 SGTC_2532 xanthone 78.9 µM 0.835123749131961 0.189837040859097 no 657 0.201824018109225 898 7020 An insecticide. SGTC_1143 3454-2408 5.08 µM 0.834296465979869 0.19006781989621 no 658 0.202056971407613 959 X1143 SGTC_1185 1319-0113 81.3 µM 0.831492805917668 0.190851210836526 no 659 0.202847645321068 970 4672763 SGTC_111 0083-0039 52.457 µM 0.830508862012401 0.191126610668334 no 660 0.203125569725407 927 759313 SGTC_1748 st037455 53.6035 µM 0.829739188880833 0.191342207196793 no 661 0.203343129672326 974 580690 SGTC_2669 eugenol 100 µM 0.827999170045882 0.191830160616364 no 662 0.203835484960253 980 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1181 1222-0449 220 µM 0.82566703810189 0.192485353852818 no 663 0.204496497644888 1007 658318 SGTC_1632 st005650 90 µM 0.825666473276656 0.192485512701337 no 664 0.204496657891673 967 2759605 SGTC_198 3454-2873 16.191 µM 0.824062170838681 0.192937021736379 no 665 0.204952116654358 995 710957 SGTC_1799 st045822 46.1415 µM 0.823754522980143 0.193023678884627 no 666 0.205039526226342 997 3674992 SGTC_587 k089-0003 57 µM 0.823100171999363 0.193208073146465 no 667 0.205225515506429 938 9659696 SGTC_3076 9116187 49.47 µM 0.822377286913175 0.193411905079463 no 668 0.205431101050578 968 27241210 SGTC_3189 9110682 49.47 µM 0.821950790665357 0.193532225755121 no 669 0.205552452172841 991 17122418 SGTC_1855 st056195 39.6 µM 0.815170244837928 0.195451241735129 no 670 0.207487433697252 973 4028379 SGTC_847 0342-0274 5.54 µM 0.814671807709801 0.195592762926422 no 671 0.207630097492953 1059 18097 SGTC_2876 9059903 25.97 µM 0.81410735642472 0.195753102612667 no 672 0.207791725969858 1044 6916095 SGTC_146 3448-8650 53.125 µM 0.810011804175078 0.196918885033566 no 673 0.208966695735046 1080 2891488 YIL048W NEO1 SGTC_745 0469-0705 296 µM 0.808132627832948 0.197455188733747 no 674 0.209507118285581 1117 3486736 SGTC_3066 9117245 49.47 µM 0.807491776804163 0.197638284871899 no 675 0.209691605139646 1068 17176980 SGTC_265 mycophenolic acid 32.932 µM 0.806646574086282 0.197879922743661 no 676 0.209935066350342 1079 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_514 4466-0038 2.65 nM 0.806587486272585 0.197896822231082 no 677 0.209952092845256 1033 5722064 SGTC_3012 9080433 71.4286 µM 0.805228115463764 0.198285851564929 no 678 0.210344027441347 1078 17688859 SGTC_2883 9059145 45.46 µM 0.805143699184942 0.198310025313185 no 679 0.210368380551151 1020 16476510 SGTC_2413 inermin 26.06 µM 0.804934162331012 0.198370036724249 no 680 0.210428836637969 1043 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1203 3992-3522 103 µM 0.802641918236001 0.199027251469086 no 681 0.2110908662945 1086 5322312 SGTC_1875 nocodazole 6 µM 0.801798925227583 0.199269277589474 no 682 0.211334640233904 1051 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_604 1000-0114 314 µM 0.801511480469868 0.199351844449102 no 683 0.211417800247637 1082 1572745 SGTC_1312 1218-2183 165 µM 0.800105443573478 0.199756017221189 no 684 0.211824853759244 1074 6744073 SGTC_990 3985-0011 41.3 µM 0.799100240504862 0.20004527013494 no 685 0.212116145105885 971 5399565 YGL099W LSG1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.796045617770908 0.200925799177578 no 686 0.213002760610002 992 61125 An anti-inflammatory. SGTC_571 k831-0106 44.2 µM 0.794499285667025 0.201372431799098 no 687 0.213452412324338 1006 4783639 SGTC_1793 st048256 72.231 µM 0.793947783609981 0.201531867959475 no 688 0.213612915145416 1019 672022 SGTC_60 0986-0278 202 µM 0.79300156191103 0.201805591502187 no 689 0.21388845638862 934 3110598 SGTC_1311 1190-0148 100 µM 0.791849318332921 0.202139213597336 no 690 0.21422427080171 1137 1961333 SGTC_429 1112-0049 25.5 µM 0.791786290114002 0.202157472383818 no 691 0.214242648838421 963 2836170 SGTC_2093 5331342 194.4 µM 0.791369387138874 0.2022782707929 no 692 0.21436423428115 1061 33839 SGTC_970 1315-0089 19.5 µM 0.789405111840814 0.202848003895085 no 693 0.214937634569085 1026 6811083 YLR033W RSC58 SGTC_2544 sphondin 68.51 µM 0.786492412483917 0.203694587427952 no 694 0.215789531248453 1044 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1555 citronellol 128 µM 0.785933757235784 0.203857202446025 no 695 0.215953148277403 1037 8842 A terpine precursor. SGTC_3037 9091026 49.47 µM 0.782789543479494 0.204773871705322 no 696 0.216875354483027 1123 25236398 YIL048W NEO1 SGTC_1027 k015-0025 8.67 µM 0.781775340912458 0.205070076113016 no 697 0.217173307697252 1097 3598955 SGTC_1947 st076332 61.6 µM 0.781724022867923 0.205085070644859 no 698 0.217188390234784 1065 24208416 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.780642702022777 0.205401171431349 no 699 0.217506334564144 1238 16725076 SGTC_2565 isoliquiritigenin 100 µM 0.780027360980368 0.205581182200163 no 700 0.217687385197518 960 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_596 1155-0152 116 µM 0.778192293582752 0.206118565353452 no 701 0.218227829637974 1077 280313 SGTC_2939 9044578 71.43 µM 0.777260025241421 0.206391890584123 no 702 0.218502687240923 1063 2653634 SGTC_2929 9013348 24.6 µM 0.776680564019171 0.206561886942868 no 703 0.218673628295422 1044 2995952 SGTC_528 3492-0019 172 µM 0.772777556203685 0.207709070031191 no 704 0.219827019118052 1144 2869262 SGTC_1866 st057638 64 µM 0.770159428154234 0.208480702357662 no 705 0.220602663690767 1054 688802 SGTC_3176 9106582 49.47 µM 0.769453851236335 0.20868894354135 no 706 0.220811965258233 986 17018027 SGTC_1461 k072-0203 53.8 µM 0.768117840888048 0.209083584034305 no 707 0.221208589245934 1066 5418714 SGTC_13 0199-0087 65 µM 0.766391635797751 0.209594133281136 no 708 0.221721654063694 1116 4589825 SGTC_1394 3474-0001 65.7 µM 0.765349059553768 0.209902844603259 no 709 0.222031858899538 1000 5017666 YIL048W NEO1 SGTC_1807 st050092 58.9 µM 0.76531859547 0.209911869166551 no 710 0.222040926810751 1069 5008496 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.763012095789762 0.210595799775068 no 711 0.222728091098262 962 6708630 An antioxidant. SGTC_1556 plumbagin 1.48 µM 0.762222141720531 0.210830339733343 no 712 0.222963716632274 1025 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_714 4296-0578 26.1 µM 0.761366283895734 0.211084619542947 no 713 0.223219159943836 1111 1589775 SGTC_1861 st057647 17.4 µM 0.7603643928798 0.211382514827622 no 714 0.223518400542256 1108 688668 SGTC_1651 st011928 86.1 µM 0.75750124813445 0.212235178423532 no 715 0.22437480920331 1076 720198 SGTC_611 3453-1652 23.7 µM 0.757301285555886 0.212294803626031 no 716 0.224434690449359 1121 1560575 SGTC_1242 0402-0103 60.1 µM 0.756169689349105 0.212632409440049 no 717 0.224773731648826 1078 432868 SGTC_2802 7925815 54.55 µM 0.755111993404145 0.212948250797623 no 718 0.225090893777711 1093 1262923 SGTC_3216 9129716 49.47 µM 0.753651608844967 0.213384789703161 no 719 0.225529223121502 1072 8056934 SGTC_1024 4507-0395 26 µM 0.752833251372907 0.213629641439863 no 720 0.225775061328399 1093 4201836 SGTC_2980 9014342 25.29 µM 0.750337220878008 0.214377461511822 no 721 0.226525815390209 1079 2996599 SGTC_2551 apiole 73.87 µM 0.749900177292287 0.214508557849058 no 722 0.226657413855982 994 10659 A possible DNA adduct former. SGTC_1308 1187-1617 41.4 µM 0.74809551809645 0.215050379837045 no 723 0.227201272605254 1136 2882570 SGTC_1832 st054113 55 µM 0.746507666629664 0.21552776504559 no 724 0.227680401037909 1107 1251267 SGTC_2409 alverine citrate 63.97 µM 0.744182112289832 0.216228047638834 no 725 0.228383154108981 1107 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3052 9092717 49.47 µM 0.742162362771851 0.216837312294756 no 726 0.228994484581855 1126 25237534 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.741406757428035 0.217065498210182 no 727 0.229223424246845 1127 229346 A bile salt which induces apoptosis. SGTC_3069 9117009 49.47 µM 0.740877903251597 0.217225289853748 no 728 0.229383737257315 1009 41904981 SGTC_2344 7990960 76.95 µM 0.739872830132125 0.217529156760361 no 729 0.229688580955266 1083 140813 SGTC_2240 6690706 185.951 µM 0.739496101627264 0.217643117455356 no 730 0.229802903031075 1033 805876 SGTC_2287 7945887 168.79 µM 0.738955479298574 0.217806716348884 no 731 0.229967015997958 1139 1245853 SGTC_3084 9116877 49.47 µM 0.738207975892267 0.218033036773929 no 732 0.230194038430469 1049 27241325 SGTC_734 2023-0417 80 µM 0.738062280732962 0.218077164448974 no 733 0.230238301745086 1093 3935732 SGTC_3058 9093861 49.47 µM 0.737649160729736 0.218202316879857 no 734 0.230363836675109 1130 17217477 SGTC_51 1013-0126 23.419 µM 0.73602955747448 0.218693365786904 no 735 0.230856355060346 1137 1627850 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.735550058002107 0.218838867582189 no 736 0.231002282708133 1177 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2642 cholecalciferol 100 µM 0.734378969626693 0.219194462725981 no 737 0.231358900234596 1118 9821465 A vitamin D precursor, similar to steriods. SGTC_2478 5763493 32.33 µM 0.732415388954417 0.219791438982704 no 738 0.231957534382689 1109 1365576 YLR208W SEC13 SGTC_835 0312-0010 67.2 µM 0.730874316594069 0.220260615414221 no 739 0.232427962475767 1115 1626196 SGTC_2688 kanamycin b 96.69 µM 0.729026681087134 0.220823880630774 no 740 0.232992670898064 1308 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_535 2293-4129 48.2 µM 0.727833508109475 0.221188066019544 no 741 0.233357754963391 1187 396118 YIL048W NEO1 SGTC_1967 st070177 51.4 µM 0.724690271679921 0.222149101275869 no 742 0.234321032301332 1171 5729214 SGTC_941 3237-0776 460 µM 0.724137203953981 0.222318446315022 no 743 0.234490753026498 1144 760008 SGTC_2391 6285546 200 µM 0.723120774486854 0.222629861085028 no 744 0.234802843533397 1139 846083 SGTC_2589 lobaric acid 100 µM 0.72231948972833 0.222875534774107 no 745 0.235049036500366 1158 73157 A novel microtubule depolymerizer. SGTC_2806 7952793 58.44 µM 0.721089580959413 0.223252924779762 no 746 0.235427200511132 1146 2972490 SGTC_1859 st055998 20 µM 0.720852124200537 0.223325828806446 no 747 0.235500250758139 1170 676301 SGTC_2878 9043973 25.97 µM 0.71949085451992 0.223744027490292 no 748 0.235919267583238 1146 6465167 SGTC_959 1222-0044 107 µM 0.719319142182992 0.223796811221443 no 749 0.235972152084141 1146 6083612 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.7185873098234 0.224021853107698 no 750 0.236197617336651 1146 75037 A free radical scavenger. SGTC_2139 5578692 56.4705 µM 0.71740916198938 0.224384409027433 no 751 0.236560834011828 1118 650991 YMR113W FOL3 SGTC_355 1311-2252 105 µM 0.716836964353562 0.224560613668919 no 752 0.236737350301552 1142 5338538 SGTC_258 haloperidol 50.781 µM 0.716508680294441 0.224661742097311 no 753 0.236838654794684 1155 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2851 9015922 71.43 µM 0.716235106202907 0.224746036762145 no 754 0.236923094658243 1133 2996893 SGTC_2211 7117706 200 µM 0.713631314355072 0.225549223940013 no 755 0.237727594400215 1118 822771 SGTC_1190 1486-1332 13 µM 0.713177627275313 0.225689338010864 no 756 0.237867924317434 1158 4150046 SGTC_3355 9151058 44.0485 µM 0.709493073290244 0.226829076438274 no 757 0.239009274212228 1188 17015728 SGTC_2176 5809774 33.9695 µM 0.70887412827284 0.227020851953498 no 758 0.23920129568688 1175 2870539 SGTC_2944 9067346 25.62 µM 0.7087627264475 0.227055378687407 no 759 0.239235865933846 1106 6473075 SGTC_1124 fisetin 1.16336 µM 0.707391382112534 0.227480641484957 no 760 0.239661645462709 1135 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3251 9135047 49.47 µM 0.706458586737147 0.227770163561329 no 761 0.239951499025532 1151 17682963 SGTC_459 nigericin 15.3 µM 0.704235802542839 0.228460909032452 no 762 0.240642969091436 1241 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1058 3448-5425 97.3 µM 0.703929252396373 0.228556263860128 no 763 0.240738416625412 1125 7279705 SGTC_1254 0550-0035 264 µM 0.703331596333007 0.2287422337288 no 764 0.240924562197987 1216 15121435 SGTC_1300 1094-0077 113 µM 0.701488080754799 0.229316406784371 no 765 0.241499235249143 1140 5532636 SGTC_2236 dapsone 200 µM 0.701049409263213 0.229453152341149 no 766 0.241636090439015 1213 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_117 lucigenin 22.078 µM 0.699121342934516 0.230054723360068 no 767 0.242238100705025 1191 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2318 6029776 164 µM 0.698848893919148 0.230139800584806 no 768 0.242323234396721 1192 818325 SGTC_1902 st060212 70.5 µM 0.698208829603638 0.230339741692676 no 769 0.24252330270247 1216 688944 SGTC_2447 5741742 33.78 µM 0.696116741935203 0.230993938008402 no 770 0.243177861311386 1218 1776504 SGTC_2367 9070478 135.38 µM 0.693069981768779 0.231948513065385 no 771 0.244132817402911 1166 572802 SGTC_2953 9074162 66.49 µM 0.691355725410681 0.232486567911073 no 772 0.244671010138615 1149 16451992 SGTC_2839 9003951 25.97 µM 0.690597526086298 0.23272476566563 no 773 0.244909251293767 1189 2990634 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.689204925714206 0.233162621534496 no 774 0.245347158759848 1136 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_400 oxethazaine 37.5 µM 0.688993557554359 0.23322911902045 no 775 0.245413660893346 1157 4621 A local anesthetic. SGTC_2402 5553605 200 µM 0.685768515538735 0.23424503799649 no 776 0.246429546622728 1243 6758546 SGTC_262 fenpropimorph 62.5 µM 0.683778078393566 0.234873265159954 no 777 0.247057655617235 1165 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2902 5787006 60.46 µM 0.68245597849813 0.235291064046345 no 778 0.247475334774775 1192 591003 SGTC_508 roscovitine 141 µM 0.68240383365353 0.235307550827607 no 779 0.247491816158713 1244 160355 A CDKinase inhibitor. SGTC_2991 9074669 71.4286 µM 0.681521846861406 0.235586507655065 no 780 0.24777067393033 1222 17333109 SGTC_278 4092-0821 23.9 µM 0.680526380850655 0.235901574982587 no 781 0.248085611838621 1213 877900 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.679171352078344 0.236330817754384 no 782 0.248514648405296 1165 641818 YHR062C RPP1 SGTC_662 k832-1615 104 µM 0.674993587074261 0.237656942984571 no 783 0.249839919652252 1217 5878478 SGTC_997 3996-0078 137 µM 0.674067020968131 0.237951610019433 no 784 0.250134352594065 1260 735687 SGTC_1475 4092-1048 11.7 µM 0.673322249888899 0.238188607638222 no 785 0.250371150277041 1233 2881759 SGTC_2146 5545642 200 µM 0.671496799554338 0.238770040614198 no 786 0.250952048810561 1257 825326 SGTC_2101 5377231 179.231 µM 0.670403350352637 0.239118691883735 no 787 0.25130034973173 1233 2844213 SGTC_3242 9133940 49.47 µM 0.669510756200857 0.23940350575518 no 788 0.251584860818511 1277 17248444 SGTC_911 3456-4043 236 µM 0.668814891753875 0.239625674484779 no 789 0.251806783023935 1297 914281 SGTC_3109 9122853 49.47 µM 0.667630962510037 0.240003926192497 no 790 0.252184594204191 1285 1234709 SGTC_686 1319-0111 510 µM 0.666763215364024 0.240281368000933 no 791 0.252461696250737 1290 4562600 SGTC_194 1486-1323 56.904 µM 0.665738046948251 0.240609366622713 no 792 0.252789275063844 1220 5178754 SGTC_1751 st044839 27.194 µM 0.665089553261534 0.240816975433698 no 793 0.252996608015431 1242 5291326 SGTC_2147 5545932 89.7195 µM 0.663154532724737 0.241437031927741 no 794 0.253615793917684 1244 797404 SGTC_172 1112-0046 2.638 µM 0.662996554486195 0.241487692615747 no 795 0.253666380388772 1195 2802135 YIL048W NEO1 SGTC_1306 1185-0270 9.02 µM 0.662011254232737 0.241803790369571 no 796 0.253982004553311 1239 1548076 SGTC_774 k060-0086 136 µM 0.661049657593754 0.242112500045091 no 797 0.254290234240174 1276 5911235 SGTC_1240 0356-0016 42.1 µM 0.659268750710612 0.242684803906757 no 798 0.254861602707467 1237 4305613 SGTC_1402 3909-7673 35.9 µM 0.65843659644786 0.242952471934608 no 799 0.255128812973932 1243 5328014 SGTC_2469 5655019 90.81 µM 0.658108726332547 0.243057977410454 no 800 0.255234134471732 1310 2788239 SGTC_2228 7354201 200 µM 0.657300337236031 0.243318215142676 no 801 0.25549390984886 1273 753451 SGTC_1693 xanthone 101.9 µM 0.657068342292829 0.243392927074158 no 802 0.255568486793935 1296 7020 An insecticide. SGTC_492 tmb-8 126 µM 0.656803636072883 0.243478188523127 no 803 0.25565359297154 1157 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_409 arachidonic acid 100 µM 0.65650681147828 0.243573814436101 no 804 0.255749043186002 1276 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3036 9090181 49.47 µM 0.656332835604843 0.243629872459039 no 805 0.255804997447884 1279 25236586 SGTC_1214 0358-0031 63.7 µM 0.656241191299452 0.243659404633977 no 806 0.255834474733352 1331 4301366 SGTC_2356 9061756 188.97 µM 0.654421028400578 0.24424634834012 no 807 0.256420295121197 1235 20104043 SGTC_1381 2324-0066 62.1 µM 0.654307215501029 0.244283074624951 no 808 0.256456949068767 1270 10885928 SGTC_766 1391-0721 126 µM 0.653873493422837 0.244423059686434 no 809 0.256596656201514 1276 1020919 YIL115C NUP159 SGTC_281 1672-3440 14.9 µM 0.653800448769165 0.244446639312762 no 810 0.256620188668053 1258 6833000 SGTC_1194 1488-0194 225 µM 0.653590246792833 0.244514501685652 no 811 0.256687914760768 1242 1391452 SGTC_1435 4092-0789 56.7 µM 0.653490935754322 0.24454656715345 no 812 0.256719915549248 1280 2248285 SGTC_3309 9129340 25.759 µM 0.651895916442085 0.245061875888118 no 813 0.257234159710647 1290 17158987 SGTC_361 000s-0510 1.45 µM 0.651734536901111 0.245114045885947 no 814 0.257286219294678 1259 660 SGTC_2840 9008771 71.43 µM 0.651706011043883 0.245123268208362 no 815 0.257295422048393 1234 2992978 SGTC_360 0957-0399 1.01 µM 0.651432301330143 0.245211767206811 no 816 0.257383732493189 1271 6752301 YPR165W RHO1 SGTC_2831 7999036 19.48 µM 0.651317107460328 0.245249018160518 no 817 0.25742090366454 1290 2988270 SGTC_3299 9121982 43.1275 µM 0.649106532030776 0.245964454620433 no 818 0.258134760034785 1278 17594604 YPL160W CDC60 SGTC_2350 9023895 38.85 µM 0.648796893334362 0.2460647562454 no 819 0.258234832885119 1294 2997209 SGTC_631 k072-0230 41.5 µM 0.647600366178533 0.246452554810001 no 820 0.258621730193015 1289 5773147 SGTC_1512 0259-0544 12.2 µM 0.646402878783233 0.246840992249321 no 821 0.259009238267399 1268 18476 SGTC_2643 anethole 100 µM 0.646107572445209 0.246936833199102 no 822 0.259104845818933 1260 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1146 3579-1023 7 µM 0.645396829603273 0.247167584668963 no 823 0.259335028712258 1327 X1146 SGTC_1843 st055809 45.5 µM 0.645335739373441 0.247187423749585 no 824 0.259354818471522 1274 16413835 SGTC_1846 st056244 14.8 µM 0.644298390955474 0.247524433096578 no 825 0.259690979418824 1294 5393182 SGTC_1796 st049173 110.4 µM 0.643159186167158 0.247894815749379 no 826 0.2600604066574 1234 94134 SGTC_2099 5377090 177.372 µM 0.642344229785833 0.248159958898274 no 827 0.260324851095004 1275 2243829 SGTC_440 fluspirilene 35.1 µM 0.639945866040161 0.248941134722361 no 828 0.261103896905234 1354 3396 An atypical antipsychotic. SGTC_1884 5633444 25 µM 0.638536106220218 0.249400920372457 no 829 0.261562379131987 1300 5724239 SGTC_2212 7123476 200 µM 0.636749126129125 0.249984382467417 no 830 0.262144134313545 1247 1085715 SGTC_3071 9117417 49.47 µM 0.636551545824152 0.250048938326806 no 831 0.262208497687881 1232 45595590 YGL055W OLE1 SGTC_2317 5986382 200 µM 0.635974944672378 0.250237383082339 no 832 0.262396376433127 1338 877883 SGTC_1430 4049-0248 69.1 µM 0.634220938553289 0.250811089933067 no 833 0.262968322303202 1338 22774488 SGTC_3207 9114163 49.47 µM 0.633900698673724 0.250915910310377 no 834 0.263072814797298 1359 849233 SGTC_2973 9094665 17.96 µM 0.632574931464691 0.251350104765536 no 835 0.263505630909319 1327 25237061 YIL048W NEO1 SGTC_2699 st077704 54.6 µM 0.631313918183499 0.251763460297784 no 836 0.263917644121463 1305 645852 SGTC_1817 st052116 64.4 µM 0.631039930891916 0.251853319770804 no 837 0.26400720790477 1308 4361398 SGTC_3128 9127691 49.47 µM 0.630950518329687 0.251882648027147 no 838 0.264036439354326 1298 41316314 SGTC_1096 rimcazole 32.2 µM 0.630118594270143 0.252155614221747 no 839 0.264308497468397 1241 18528119 A dopamine reuptake inhibitor. SGTC_3078 9116413 49.47 µM 0.629178752827394 0.252464177247981 no 840 0.264616018629551 1235 17177322 SGTC_1299 1079-1439 3.74 µM 0.62885036548687 0.252572038272339 no 841 0.264723511619337 1262 323161 SGTC_413 propylparaben 100 µM 0.62859869774151 0.252654716659894 no 842 0.264805906552447 1265 7175 A pharmaceutical preservative. SGTC_1710 st031758 61.5 µM 0.626744441919082 0.253264319620019 no 843 0.265413383544203 1348 5394341 SGTC_127 0180-0333 59.125 µM 0.625384912492418 0.253711767795812 no 844 0.265859230987891 1270 771601 SGTC_572 0960-0087 17.7 µM 0.625003324889972 0.253837430432188 no 845 0.265984437950721 1274 6796365 SGTC_1029 k015-0030 64.7 µM 0.624328926164343 0.254059600123527 no 846 0.266205795461015 1339 2208316 SGTC_620 0109-0052 432 µM 0.623315909004492 0.25439351375034 no 847 0.266538472670865 1308 493037 SGTC_712 r015-0009 80.6 µM 0.62155561266543 0.254974294330207 no 848 0.267117057804106 1296 6813872 YLR060W FRS1 SGTC_1309 pyrazolanthrone 13.4 µM 0.620980693797297 0.255164129459706 no 849 0.267306162977103 1344 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2426 5582046 32.21 µM 0.62055592999628 0.255304431653056 no 850 0.267445921775164 1333 2251934 SGTC_640 3381-0960 37.1 µM 0.619531092587616 0.255643107939823 no 851 0.267783272702248 1365 1745025 SGTC_2270 7924575 90.91 µM 0.619438668786185 0.255673662607083 no 852 0.267813706849552 1328 1262135 SGTC_2111 5486399 200 µM 0.617840511193323 0.256202303845664 no 853 0.26834023809228 1318 689674 SGTC_76 0433-0009 400.328 µM 0.616674369603765 0.256588401443168 no 854 0.268724765031416 1323 2841569 SGTC_1620 st003704 16.5 µM 0.615790945912743 0.256881095638633 no 855 0.269016251918116 1283 2834414 SGTC_3134 9127454 49.47 µM 0.615732813760225 0.256900361959611 no 856 0.269035438267005 1395 24262820 SGTC_669 0108-0021 26.2 µM 0.612982962228036 0.257812583754159 no 857 0.26994380270752 1478 17201 SGTC_457 grayanotoxin iii 135 µM 0.61288728651254 0.257844352965755 no 858 0.269975435086362 1282 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1260 0700-1617 7.75 µM 0.612386858732986 0.258010553577659 no 859 0.270140917124932 1350 2853078 SGTC_2823 7987624 58.44 µM 0.612299045442421 0.258039723600833 no 860 0.270169960557475 1352 2239440 SGTC_3118 9124250 49.47 µM 0.610777702550013 0.258545358192507 no 861 0.270673378397247 1270 1504786 SGTC_3197 9113331 49.47 µM 0.610752113349017 0.258553867423096 no 862 0.27068184996009 1391 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_324 1315-0088 19.6 µM 0.610373425551825 0.25867981022133 no 863 0.270807233847054 1272 6787421 SGTC_1090 efavirenz 20.7 µM 0.610040230852582 0.258790649326477 no 864 0.27091757889754 1337 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_473 2-arachidonoylglycerol 10 µM 0.608471835136648 0.259312714988229 no 865 0.271437290207576 1286 5282280 An endocannabinoid. SGTC_2807 7945238 51.95 µM 0.60738844330295 0.259673656859896 no 866 0.271796578063547 1368 17148797 SGTC_484 loperamide 105 µM 0.606482238856073 0.259975766191213 no 867 0.272097286495429 1310 3955 An opioid-receptor agonist. SGTC_703 3875-0075 71.8 µM 0.603907437019719 0.260835138601067 no 868 0.272952592024616 1388 2850814 SGTC_3051 9093778 49.47 µM 0.603698541107015 0.260904924266193 no 869 0.273022042127 1339 17217378 SGTC_2076 5212012 200 µM 0.602230668043232 0.261395565937394 no 870 0.273510302096844 1264 604802 SGTC_2055 5235184 200 µM 0.600775005939724 0.26188259358836 no 871 0.273994926763936 1355 2836034 SGTC_2960 9079389 5.97 µM 0.60024001481634 0.262061704932707 no 872 0.274173144667534 1374 16457355 SGTC_1945 st075991 56.6 µM 0.59764235222143 0.262932276198615 no 873 0.275039299197355 1259 1084980 SGTC_713 1488-1073 324 µM 0.597308279725527 0.263044343253592 no 874 0.275150788774748 1324 3312542 SGTC_934 2950-0684 338 µM 0.596813696948436 0.263210299463506 no 875 0.275315886088592 1383 1121253 SGTC_1028 k015-0029 4.8 µM 0.595608926107582 0.263614781485557 no 876 0.27571825611063 1335 4588309 SGTC_1625 st003711 30.1 µM 0.594156436718894 0.264102852234235 no 877 0.276203743295101 1425 24207034 YER133W GLC7 SGTC_740 k014-0057 261 µM 0.593516008022206 0.264318197554052 no 878 0.276417936517686 1408 4012779 SGTC_490 phenamil 164 µM 0.592123786056701 0.264786642943673 no 879 0.276883850013416 1363 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.590679152035524 0.265273169418903 no 880 0.277367709649896 1415 1273210 SGTC_1831 st055328 12 µM 0.590504207732468 0.265332118272373 no 881 0.277426332810743 1365 1103068 SGTC_2917 7979103 53.79 µM 0.58989264486119 0.265538241408743 no 882 0.277631312752677 1415 2980565 SGTC_1888 azatryptophan 97.5 µM 0.587993188152277 0.266178957973323 no 883 0.278268432529601 1332 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1223 0764-0573 147 µM 0.586191993268415 0.266787251468665 no 884 0.278873250822857 1350 1609797 SGTC_681 1642-0006 26.6 µM 0.585839558990977 0.266906356514653 no 885 0.278991668543204 1354 4446530 SGTC_150 3970-0969 77.2 µM 0.585572967851062 0.26699646874211 no 886 0.279081259261566 1409 6615640 SGTC_1122 capsaicin 818.572 nM 0.584785177205609 0.267262844804965 no 887 0.279346086200635 1458 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2628 lathosterol 100 µM 0.584713308264848 0.267287152561105 no 888 0.279370252034729 1398 6710616 SGTC_2015 5119600 184 µM 0.584035177062401 0.267516567298117 no 889 0.279598322721268 1410 2828786 SGTC_1640 st009078 66.4 µM 0.583987004769095 0.267532867970879 no 890 0.279614527578358 1405 690618 SGTC_867 0518-0118 155 µM 0.583763016103361 0.267608668447576 no 891 0.279689881947098 1385 6848158 SGTC_1132 3456-3614 2.5 µM 0.583339822256708 0.26775191191387 no 892 0.279832279907072 1505 3125502 SGTC_701 4424-0219 185 µM 0.582131612114245 0.268161081693185 no 893 0.280239016706152 1398 2911779 SGTC_36 0335-0881 14.2 µM 0.581762150830316 0.268286265430322 no 894 0.280363450815283 1323 23828853 SGTC_2620 irigenin 100 µM 0.580703281196635 0.268645202635574 no 895 0.280720224960661 1445 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2850 9015429 58.44 µM 0.579334915545623 0.26910941040296 no 896 0.281181605279263 1364 6457570 SGTC_2408 sulbentine 18.36 µM 0.577066420204855 0.2698798661049 no 897 0.281947293728762 1459 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1744 st037937 38.9 µM 0.576445219027999 0.270091038902262 no 898 0.282157143689796 1424 1016152 SGTC_2123 5259487 200 µM 0.576206238215452 0.27017230069388 no 899 0.282237894585871 1391 2173474 SGTC_1436 4092-1007 8.32 µM 0.575341887580722 0.27046631204122 no 900 0.282530048881952 1347 2881121 SGTC_1366 1683-0113 21.9 µM 0.574355081842627 0.270802172187471 no 901 0.282863771194939 1368 708623 SGTC_754 3474-0146 171 µM 0.573998307723616 0.270923651773647 no 902 0.282984473217694 1301 24762078 SGTC_2624 nerol 100 µM 0.573386545347496 0.271132016699626 no 903 0.283191499114131 1387 637566 A natural product oil. SGTC_2814 7977482 42.97 µM 0.572578150710361 0.271407476654716 no 904 0.283465178532245 1460 6456762 SGTC_2636 apigenin dimethyl ether 100 µM 0.572289137762196 0.271505991456921 no 905 0.28356305369492 1386 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1156 4092-0367 4.88 µM 0.572258815108588 0.271516328462866 no 906 0.283573323497407 1381 1357585 SGTC_180 1486-1293 102.781 µM 0.57184405075855 0.271657741487078 no 907 0.283713815500368 1480 4140536 SGTC_654 1124-0271 80.9 µM 0.571614302703108 0.271736089376411 no 908 0.283791651779633 1355 5403748 SGTC_2011 4012611 177 µM 0.571572507239801 0.27175034353013 no 909 0.283805812752013 1359 2049887 SGTC_1756 st041558 35.5 µM 0.57067723551865 0.27205576123236 no 910 0.284109226356553 1492 3955792 SGTC_2827 7993847 71.43 µM 0.568154295615833 0.27291736737807 no 911 0.284965101289552 1397 2985692 SGTC_3106 9121286 49.47 µM 0.56803483015885 0.272958199411175 no 912 0.285005658882696 1409 15943471 SGTC_568 1193-0097 7.48 µM 0.567888632880337 0.273008172220118 no 913 0.285055295466288 1311 3646150 SGTC_162 k030-0015 37.8 µM 0.567726904467457 0.273063459128246 no 914 0.285110209948136 1452 1809920 YMR134W ERG29 SGTC_2210 7115885 190.385 µM 0.567247220785238 0.273227471776733 no 915 0.285273115006724 1375 2927039 SGTC_1882 5615643 20 µM 0.566577523700736 0.273456535094162 no 916 0.285500624537875 1327 2253075 SGTC_1525 8-methoxypsoralen 92.5 µM 0.565081517313425 0.273968572543542 no 917 0.286009159672823 1482 4114 Related to psoralen; DNA damaging agent. SGTC_2743 auranofin 4.32 µM 0.563630966332261 0.274465504073657 no 918 0.286502653906102 1389 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1510 1123-0200 71.5 µM 0.562778556883643 0.274757730894694 no 919 0.286792841801767 1502 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.562345348238502 0.274906304188666 no 920 0.28694037348549 1397 6708784 An antioxidant flavonoid SGTC_1340 1486-1359 257 µM 0.561449656230245 0.275213616335052 no 921 0.287245520493972 1413 4309068 SGTC_467 ro 31-8220 72.8 µM 0.557259887322997 0.276653368973458 no 922 0.288674938914871 1388 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1498 4478-3555 97.6 µM 0.556911460702907 0.276773266711793 no 923 0.288793961931083 1409 3437919 SGTC_2568 diosmetin 100 µM 0.556490662322962 0.276918102358917 no 924 0.288937738032351 1406 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2215 7188065 200 µM 0.555556754876041 0.277239678820339 no 925 0.289256950715676 1434 940217 SGTC_2080 5212524 12.4 µM 0.555214881863779 0.277357443115358 no 926 0.289373845484549 1425 260183 SGTC_2567 aureobasidin a 60 nM 0.554213030116145 0.277702689729678 no 927 0.289716530932693 1487 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_503 tyrphostin 8 294 µM 0.552780533176649 0.278196704669623 no 928 0.290206850019116 1406 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2050 5263056 171 µM 0.552454791095929 0.278309100779127 no 929 0.290318400164955 1409 763468 YGL055W OLE1 SGTC_808 0711-0032 135 µM 0.552410652917793 0.278324332198256 no 930 0.290333516797579 1414 4252555 SGTC_845 0330-0138 4.51 µM 0.551905466091813 0.278498693481627 no 931 0.290506561595996 1439 9039800 SGTC_829 1635-0120 117 µM 0.551708411211448 0.278566719856775 no 932 0.29057407311852 1478 285054 SGTC_2459 5811157 9.22 µM 0.550119798495837 0.279115428819393 no 933 0.291118603983928 1378 2870684 YBR192W RIM2 SGTC_1987 st072290 61.9 µM 0.54848853304809 0.279679416377465 no 934 0.291678250407037 1432 54697379 SGTC_2795 7780010 54.55 µM 0.545586517464745 0.280684113314578 no 935 0.292675097107355 1416 953673 SGTC_1089 terbinafine 2.25 µM 0.5446518597079 0.28100806928421 no 936 0.292996490020514 1459 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2046 4110841 106 µM 0.543987047360814 0.281238605702557 no 937 0.293225193070262 1414 44119630 YMR134W ERG29 SGTC_2060 5238662 140 µM 0.542527970345724 0.281744888522205 no 938 0.293727422163767 1406 790130 SGTC_1128 3448-9350 235 µM 0.542036806862864 0.281915415343853 no 939 0.293896575124144 1410 619386 SGTC_859 0439-0102 54.6 µM 0.541268212531253 0.282182362997401 no 940 0.294161363528239 1449 610143 SGTC_290 2043-6722 48.1 µM 0.541012951901415 0.282271046850429 no 941 0.294249327735934 1439 773758 YLR208W SEC13 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.540198853254636 0.282553974407973 no 942 0.294529951715627 1503 23847180 SGTC_3313 9133968 57.047 µM 0.537416914275273 0.283521822449596 no 943 0.295489831170076 1395 1494643 SGTC_1247 0448-0043 5.84 µM 0.537131034593226 0.28362137111882 no 944 0.295588552480353 1447 3089013 YGL099W LSG1 SGTC_968 1309-0633 340 µM 0.537026405152936 0.283657809238271 no 945 0.295624687398472 1425 3761976 SGTC_273 hydroxyurea 18.1 mM 0.536050538050101 0.283997771453937 no 946 0.295961811489361 1453 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_659 k018-0002 107 µM 0.534326705620321 0.284598777777751 no 947 0.296557759358867 1455 6797879 YHR007C ERG11 SGTC_315 k915-0449 187 µM 0.533920123464329 0.284740619257672 no 948 0.296698399377331 1483 20970215 YNL149C PGA2 SGTC_2948 9070189 9.45 µM 0.532720151483739 0.285159441730508 no 949 0.297113657257541 1458 6473636 YDL196W YDL196W SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.532707899016713 0.285163719684656 no 950 0.297117898671341 1454 368090 SGTC_282 k297-0036 65.7 µM 0.528680191649544 0.286571650368507 no 951 0.298513660275238 1456 5061378 SGTC_100 0086-0128 49.5915 µM 0.528394004800996 0.286671815558646 no 952 0.29861294886387 1352 93297 SGTC_1250 0485-0349 40.2 µM 0.527877090916718 0.286852777106166 no 953 0.298792323072165 1442 6842794 YDL195W SEC31 SGTC_386 1509-0011 3.07 µM 0.523912338288305 0.288242557034234 no 954 0.300169756361237 1438 3107280 SGTC_1755 st041960 45.185 µM 0.523883179775834 0.288252789833082 no 955 0.300179897232613 1462 2257073 SGTC_1209 2323-2347 50.3 µM 0.52292604018363 0.288588780543481 no 956 0.300512861271025 1462 5412760 SGTC_2533 agelasine 13.65 µM 0.522740999519037 0.288653757804009 no 957 0.300577251354025 1585 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3093 9117344 49.47 µM 0.522528572773188 0.288728360215994 no 958 0.300651178870723 1441 24824913 SGTC_1220 1838-0075 193 µM 0.5212928863168 0.289162502382113 no 959 0.301081377893584 1444 5529645 SGTC_252 miconazole 1.30953 nM 0.521072676028428 0.289239902578265 no 960 0.301158072291414 1424 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_550 4123-0385 25.7 µM 0.520867211540269 0.289312128655704 no 961 0.301229638988147 1419 5731123 SGTC_1278 0874-0585 172 µM 0.519208622580941 0.28989547566344 no 962 0.301807633377114 1468 766306 SGTC_2157 5649910 96.377 µM 0.515696310337411 0.291132618520923 no 963 0.303033266005861 1416 2858091 SGTC_22 0964-0034 14.468 µM 0.515094128820794 0.291344972451233 no 964 0.303243622621885 1412 138402 SGTC_562 3772-2733 112 µM 0.514620601776054 0.291512008281217 no 965 0.303409082946273 1452 2876874 YIL048W NEO1 SGTC_1521 st012942 49.4 µM 0.514569713317233 0.291529961752828 no 966 0.303426866845929 1622 24207259 SGTC_519 k048-0011 62.8 µM 0.514173319028751 0.291669827488341 no 967 0.303565409995664 1489 6836379 SGTC_624 k048-0052 28 µM 0.513830446166495 0.291790833679736 no 968 0.303685269733767 1457 6835531 SGTC_1813 st051246 8.6015 µM 0.51350703745353 0.291904992043877 no 969 0.303798344648804 1483 5291959 SGTC_219 mitoxanthrone 164.414 µM 0.51323118300651 0.292002380909392 no 970 0.303894807782733 1500 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2999 9069765 71.4286 µM 0.512681447470015 0.292196507057267 no 971 0.304087084714674 1514 2097066 SGTC_1939 st074455 53.6 µM 0.512274500856735 0.292340249327981 no 972 0.304229454334207 1567 1644229 SGTC_3086 9117350 49.47 µM 0.511678542140078 0.292550814046786 no 973 0.304438003094019 1404 2679265 SGTC_3256 9138902 49.47 µM 0.511468390513531 0.292625081830032 no 974 0.304511558361419 1516 17228773 SGTC_2674 ligustilide 100 µM 0.511467846698366 0.292625274026187 no 975 0.304511748712672 1453 5319022 A signalling regulator. SGTC_1547 harmine 94.2 µM 0.510927409684444 0.292816305249821 no 976 0.304700943678308 1465 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_672 1441-0018 53.7 µM 0.510907032470659 0.292823509227426 no 977 0.304708078309565 1421 251141 SGTC_898 1000-0849 28.3 µM 0.508348435778903 0.293728705613275 no 978 0.305604503883453 1474 6751807 SGTC_1470 k295-0292 231 µM 0.507911584822351 0.29388338681504 no 979 0.305757674966052 1532 5045612 SGTC_2110 5483698 200 µM 0.505197719773054 0.294845161397334 no 980 0.306709985855497 1475 2848765 YHR062C RPP1 SGTC_2664 lyso-paf C-16 73.48 µM 0.502820980436579 0.295688650804318 no 981 0.307545070741317 1486 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1845 st056753 3.01 µM 0.501175297232346 0.296273342102323 no 982 0.308123878972278 1406 5375839 SGTC_1820 st053765 18.6 µM 0.49986532628713 0.296739137571235 no 983 0.308584954266961 1457 3690829 SGTC_2105 5350118 200 µM 0.49949733575953 0.296870046817225 no 984 0.308714531609674 1465 2133313 SGTC_2145 5634607 200 µM 0.49881461657879 0.29711298786121 no 985 0.308954994728903 1440 308662 SGTC_332 4112-0506 40.9 µM 0.498695501381993 0.297155383517248 no 986 0.308996957139304 1506 2790355 SGTC_2035 5154463 94.595 µM 0.498202000650025 0.297331060481052 no 987 0.30917083623799 1538 2769623 SGTC_2847 9005661 71.43 µM 0.497226678192269 0.29767839638455 no 988 0.309514605195771 1438 2991449 SGTC_2752 diclazuril 33.15 µM 0.496989108491893 0.297763028730687 no 989 0.309598365934985 1517 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1452 4194-0072 190 µM 0.496954675489175 0.297775296129033 no 990 0.309610506913948 1599 1343545 SGTC_349 k015-0014 24 µM 0.495249876622465 0.298382950498842 no 991 0.310211873709654 1453 2196908 SGTC_2812 7970281 58.44 µM 0.49386602824189 0.298876620660836 no 992 0.310700398980143 1593 2233435 SGTC_778 3456-2434 196 µM 0.493774091696027 0.29890943098594 no 993 0.310732866200012 1635 5539063 SGTC_1206 3978-0017 132 µM 0.493404221523152 0.299041446825686 no 994 0.310863500053022 1562 3873677 SGTC_3351 9150312 21.596 µM 0.492832647833752 0.299245507702981 no 995 0.311065420133202 1480 4904905 SGTC_2074 5212007 75.395 µM 0.491576471045246 0.299694204603192 no 996 0.311509390067729 1538 758611 SGTC_2584 androsterone 48.74 µM 0.489441635217762 0.300457450101366 no 997 0.312264532802381 1513 2754130 A steroid. SGTC_2706 st078239 82.5 µM 0.483770963180576 0.302489076675708 no 998 0.314274212258492 1478 15434492 SGTC_2520 obtusaquinone 4.71 µM 0.483022330241467 0.302757748332424 no 999 0.314539940485982 1591 5967872 SGTC_1852 st056254 31.4 µM 0.477186495992822 0.304855783342616 no 1000 0.316614663131256 1565 442583 SGTC_1940 st075990 51.1 µM 0.475449779195542 0.30548139387658 no 1001 0.317233210389776 1597 1084979 SGTC_3082 9117008 49.47 µM 0.475331169531124 0.305524140917084 no 1002 0.31727547294123 1519 41448529 SGTC_1986 st071812 45 µM 0.47467296286293 0.305761407418553 no 1003 0.317510045964383 1517 11838594 SGTC_1213 1315-0166 115 µM 0.474144729497687 0.305951880901765 no 1004 0.317698351860364 1461 768401 SGTC_2290 7904846 200 µM 0.47328666813725 0.306261397565843 no 1005 0.318004336154395 1504 2962154 SGTC_3124 9127567 49.47 µM 0.472344432983219 0.306601436426166 no 1006 0.318340479953455 1639 17592030 SGTC_2829 7992743 58.44 µM 0.471960210330937 0.306740144573104 no 1007 0.318477594922333 1643 16462845 SGTC_2121 5257820 149.641 µM 0.471824760644196 0.306789049838756 no 1008 0.318525937875407 1593 791256 SGTC_3091 9116372 49.47 µM 0.471544527190334 0.306890241437284 no 1009 0.3186259649887 1521 17169793 SGTC_1602 st001878 87.6 µM 0.471005176916027 0.307085040881153 no 1010 0.318818518998293 1559 595405 YLR310C CDC25 SGTC_3136 9095672 49.47 µM 0.470213155295276 0.30737119741709 no 1011 0.319101368127517 1530 17217380 SGTC_1867 st057372 64 µM 0.469834903634214 0.307507900722136 no 1012 0.319236487673462 1509 688837 SGTC_694 1315-0438 43.2 µM 0.469076620086655 0.307782031239958 no 1013 0.319507435012454 1573 6793154 SGTC_1113 artemisinin 1.17947 µM 0.468991875288054 0.307812674386411 no 1014 0.319537721730702 1612 2240 An anti-malaria and mitochondrial poison. SGTC_3224 9130643 49.47 µM 0.468903799637143 0.307844523367111 no 1015 0.319569200129056 1583 17644395 SGTC_3019 9081971 49.47 µM 0.468855461605934 0.307862003467486 no 1016 0.319586476782171 1633 16451803 SGTC_952 1185-0122 232 µM 0.468420879010457 0.308019177717069 no 1017 0.319741819943392 1468 678600 SGTC_1749 st037932 54.2 µM 0.467722325604911 0.308271895337141 no 1018 0.319991586715715 1508 594497 SGTC_2372 9071633 200 µM 0.466340069394162 0.308772225847442 no 1019 0.320486050896517 1561 21321366 SGTC_2780 5215298 71.43 µM 0.465961632970339 0.308909269137694 no 1020 0.320621481755475 1630 2834131 SGTC_108 0509-0257 621.132 µM 0.465411181566131 0.309108651754712 no 1021 0.32081851416262 1502 536624 SGTC_1907 st060210 83.7 µM 0.462650620520624 0.310109420068284 no 1022 0.321807409099674 1607 688793 SGTC_1041 0206-0046 107 µM 0.460671238645238 0.310827859968526 no 1023 0.322517246423343 1556 50494 SGTC_3048 9093155 49.47 µM 0.460505866343526 0.310887916495434 no 1024 0.322576580860467 1525 25236002 SGTC_1369 1866-0067 208 µM 0.459597560666243 0.311217866143895 no 1025 0.322902555185626 1647 3531355 SGTC_165 k038-0023 64.381 µM 0.458592426152394 0.31158316655762 no 1026 0.323263438249564 1492 46368543 SGTC_1608 st001473 40.5 µM 0.457897167464185 0.311835956026739 no 1027 0.323513160997335 1487 7292267 SGTC_210 3551-0445 56.827 µM 0.457777440631717 0.311879496521072 no 1028 0.323556172462831 1572 2865180 YOR207C RET1 SGTC_1284 0929-0043 16 µM 0.4574269178457 0.312006984609471 no 1029 0.323682110157755 1524 1239883 SGTC_1565 sinapyl alcohol 95.1 µM 0.45741153491874 0.312012580025517 no 1030 0.323687637480403 1464 5280507 A phenol propionate derived from cinnamic acid. SGTC_2843 9000894 45.46 µM 0.456639263576636 0.312293543248513 no 1031 0.323965176436881 1468 2242070 SGTC_917 harmaline 728.087 nM 0.45607880443113 0.312497514586061 no 1032 0.324166655611234 1592 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3262 9137218 49.47 µM 0.455566359983913 0.312684061925591 no 1033 0.324350919084693 1493 17650664 SGTC_761 k216-0224 480 µM 0.45453346303557 0.313060217635545 no 1034 0.3247224562592 1709 1340404 SGTC_2641 levomentholum 100 µM 0.454352215304922 0.313126243695154 no 1035 0.324787669797614 1532 16666 SGTC_1341 1486-1360 280 µM 0.454139316950716 0.313203807295586 no 1036 0.324864278195122 1517 3976547 SGTC_2231 micatex 6.853 µM 0.453955796897337 0.313270674361459 no 1037 0.324930321180125 1567 20737 An antifungal of unknown mechanism. SGTC_1917 st066507 28.5 µM 0.453296011382126 0.31351112343216 no 1038 0.325167802276759 1530 3156428 SGTC_3143 9086658 49.47 µM 0.45246161381302 0.313815320789013 no 1039 0.325468234392658 1547 25236626 SGTC_953 1188-0045 9.7 µM 0.451620247358492 0.314122187002651 no 1040 0.325771290585605 1611 6144426 SGTC_69 0096-0274 206.684 µM 0.451545917440288 0.314149303062018 no 1041 0.325798069407967 1628 6741392 SGTC_2597 laccaic acid a 100 µM 0.450217006203046 0.314634268107397 no 1042 0.326276987521201 1563 5491415 A textile dye. SGTC_1350 1495-0454 146 µM 0.449123219890355 0.315033668149902 no 1043 0.326671385484647 1621 1069057 SGTC_1974 st069448 26.9 µM 0.449004110233327 0.315077174545326 no 1044 0.326714345806199 1640 6323587 YNR016C ACC1 SGTC_2769 toremifene 3.73 µM 0.448803755130118 0.315150362713686 no 1045 0.326786614815963 1586 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_512 prima-1 270 µM 0.447605738945856 0.315588140092634 no 1046 0.327218880305831 1625 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1179 1021-1431 9.29 µM 0.447267106821296 0.315711929527652 no 1047 0.327341106835866 1579 2840958 SGTC_53 0973-0023 39.979 µM 0.446602754533883 0.315954848401352 no 1048 0.327580953206991 1627 674768 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.445852161072916 0.316229396803613 no 1049 0.327852020241707 1520 688669 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.44527591463692 0.316440242184083 no 1050 0.328060185694425 1583 1609 A potent and irreversible inhibitor of serine proteases. SGTC_292 k038-0015 474 µM 0.445026162847675 0.316531643522371 no 1051 0.328150423576964 1586 46368540 SGTC_444 curcumin 90.4 µM 0.444696033460046 0.316652477740955 no 1052 0.32826971810087 1573 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_5 0352-0601 109.883 µM 0.444523489509906 0.316715640200729 no 1053 0.328332075013443 1565 762456 SGTC_2343 7990716 14.84 µM 0.444249186709124 0.31681606410784 no 1054 0.328431217142149 1602 6456862 SGTC_994 3910-0338 138 µM 0.443561129729723 0.317068025298823 no 1055 0.328679956902211 1640 3479481 SGTC_2271 7849410 118.62 µM 0.443457967046681 0.317105809998854 no 1056 0.328717257833576 1638 972430 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.442958896355408 0.317288628175457 no 1057 0.328897732849649 1600 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.442708401863871 0.317380405425309 no 1058 0.328988332248218 1521 6312947 SGTC_1269 0831-0796 3.05 µM 0.442080252255506 0.317610598956331 no 1059 0.329215566958939 1638 927758 SGTC_1020 4335-0961 93.3 µM 0.442048479402032 0.317622244403341 no 1060 0.329227062546552 1489 669075 SGTC_1563 conessine 56.1 µM 0.441855660805092 0.317692920514423 no 1061 0.329296828804618 1613 441082 An anti-amoebic, histamine inhibitor. SGTC_878 0828-0289 13.7 µM 0.441058038113813 0.317985353280511 no 1062 0.329585490396073 1551 745350 YLR208W SEC13 SGTC_1754 st042065 16.137 µM 0.440866632286153 0.318055545382708 no 1063 0.329654775747251 1508 1126236 YIL048W NEO1 SGTC_684 1140-0066 328 µM 0.440663968515313 0.318129873107425 no 1064 0.329728142637327 1554 6813534 SGTC_23 0213-0011 39.996 µM 0.439976619305508 0.318382015633745 no 1065 0.329977020669196 1649 627608 SGTC_2767 sibutramine 71.45 µM 0.43972263853511 0.318475205517822 no 1066 0.330069002049968 1684 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3183 9108214 49.47 µM 0.439665353927181 0.318496225806839 no 1067 0.330089749597047 1546 4974831 SGTC_2214 7179297 48.276 µM 0.439533061698648 0.318544771984713 no 1068 0.330137665672981 1624 769744 SGTC_940 3232-1287 54.8 µM 0.439457424143831 0.31857252946836 no 1069 0.330165062750532 1574 1585493 YIL048W NEO1 SGTC_594 1487-1584 10.8 µM 0.43890850511003 0.31877400237539 no 1070 0.330363916886261 1513 5013332 SGTC_358 0075-0058 9.45 µM 0.437810196319424 0.319177281757348 no 1071 0.330761939482684 1805 1069125 SGTC_725 1497-0963 19 µM 0.436147820672864 0.319788083543576 no 1072 0.331364741623003 1709 3549977 SGTC_200 k038-0079 37.545 µM 0.43528766504219 0.320104320080075 no 1073 0.331676818577016 1613 3436683 SGTC_511 blebbistatin 171 µM 0.434475712223275 0.320402954799276 no 1074 0.331971514081965 1656 3476986 A myosin inhibitor. SGTC_2415 st077333 57.7 µM 0.433520554796274 0.320754408819661 no 1075 0.332318318303592 1823 2766255 SGTC_820 1582-0060 59.9 µM 0.431563806253882 0.32147490395218 no 1076 0.333029234414885 1550 3848840 SGTC_2165 5727197 32.143 µM 0.431503017561367 0.321497297758756 no 1077 0.333051329489535 1649 1361712 SGTC_2337 9009472 200 µM 0.42901183464472 0.322415576175441 no 1078 0.333957306085372 1681 5742383 SGTC_3289 9119912 71.43 µM 0.428873123825845 0.322466738490971 no 1079 0.334007780015463 1590 17014829 SGTC_2875 9039966 71.43 µM 0.428816002974002 0.322487808012829 no 1080 0.334028565956948 1692 6463691 SGTC_2879 9041815 71.43 µM 0.427090892852914 0.323124398208592 no 1081 0.33465656299781 1559 4942971 SGTC_2572 astragaloside iv 100 µM 0.425833359660101 0.323588772658073 no 1082 0.335114638369609 1613 45006101 An anti-inflammatory agent. SGTC_2102 5377816 72.7585 µM 0.42567414146301 0.323647587433252 no 1083 0.335172653503641 1710 1379702 SGTC_2591 skatole 100 µM 0.425627412702928 0.323664849748169 no 1084 0.33518968104303 1593 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2863 9028737 58.44 µM 0.423435646917419 0.324474947080801 no 1085 0.335988720706154 1693 6460917 SGTC_1379 2144-0755 36.5 µM 0.422014178651177 0.32500077985445 no 1086 0.336507334166752 1687 5392327 SGTC_1482 3346-2049 8.48 µM 0.421881477863587 0.325049886647679 no 1087 0.336555765082152 1641 3826804 SGTC_373 0844-0104 25.9 µM 0.421569169033961 0.325165470562511 no 1088 0.336669757037185 1706 5375804 SGTC_3254 9136651 49.47 µM 0.420353712139843 0.325615465071214 no 1089 0.337113538605687 1557 16454030 SGTC_2657 nystatin 74.44 µM 0.419391006237653 0.325972064922721 no 1090 0.337465197974072 1638 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1505 k297-0037 20.6 µM 0.417640459303 0.326620900062931 no 1091 0.338105005380983 1575 4089396 SGTC_2449 5812982 45.77 µM 0.417417231688107 0.326703676497315 no 1092 0.338186626516503 1593 776185 SGTC_2136 5328288 199.296 µM 0.416738841207936 0.326955287077472 no 1093 0.338434720454905 1576 262395 SGTC_2909 7941780 10.49 µM 0.416682355553941 0.326976240786384 no 1094 0.338455380968022 1717 1243215 SGTC_2741 miltefosine 3.04 µM 0.412785461878505 0.328423131936682 no 1095 0.339881901917734 1601 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_12 0849-0099 9.267 µM 0.411446107135826 0.328921021781726 no 1096 0.34037272558647 1670 6071388 SGTC_2371 9071574 200 µM 0.410788790825353 0.329165482783903 no 1097 0.340613706569724 1628 45596039 SGTC_2067 5224629 34.075 µM 0.410253887029542 0.329364471557976 no 1098 0.340809857513048 1571 2835000 SGTC_2704 st078022 71.1 µM 0.408564701649904 0.329993180060001 no 1099 0.341429569634835 1745 54697681 SGTC_1928 4'-methoxychalcone 40.3 µM 0.406588934773819 0.330729162767466 no 1100 0.342154962791879 1791 641818 SGTC_2223 6903751 107.57 µM 0.406182700803272 0.330880568143817 no 1101 0.342304181940329 1671 5598863 SGTC_3342 9147791 14.508 µM 0.405511768127898 0.331130688587772 no 1102 0.342550684963907 1601 1838168 SGTC_397 arbidol 50 µM 0.405458355271759 0.331150603881614 no 1103 0.342570311918733 1702 131410 A RNA synthesis inhibitor. SGTC_2776 terbinafine 19.92 µM 0.403111343921521 0.332026171639938 no 1104 0.343433157883359 1601 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1673 st016611 27.3 µM 0.401938904803018 0.332463901771945 no 1105 0.343864494912799 1711 5226799 SGTC_3027 9089541 49.47 µM 0.401029389090703 0.332803626930143 no 1106 0.344199243227929 1606 9943819 SGTC_1357 1503-1303 39.5 µM 0.399514725501048 0.333369693475914 no 1107 0.344756987836483 1612 292895 SGTC_2226 7298446 200 µM 0.398155738545164 0.333877903118667 no 1108 0.345257695010255 1709 3283010 SGTC_963 1269-2853 151 µM 0.397843007676869 0.333994895799046 no 1109 0.345372956421256 1574 3668223 SGTC_2964 9083345 53.42 µM 0.395387959045711 0.334913889729379 no 1110 0.346278296982247 1581 17741579 SGTC_321 4534-3890 65.3 µM 0.394797821968196 0.335134942388687 no 1111 0.346496051225678 1750 699746 SGTC_189 3970-0742 2.116 µM 0.394365329263666 0.335296981125871 no 1112 0.346655668610797 1729 2891807 SGTC_1973 st070275 50.2 µM 0.394336263055958 0.335307872239262 no 1113 0.346666396871467 1648 17118334 SGTC_1798 st045719 60.953 µM 0.393496933052208 0.335622429026432 no 1114 0.34697624437671 1694 3980186 SGTC_1738 st035555 74 µM 0.393243268578684 0.335717517872777 no 1115 0.347069907436263 1641 5331140 SGTC_569 4130-2812 160 µM 0.392668583750368 0.335932983545618 no 1116 0.347282138592667 1676 743552 SGTC_851 0394-0702 453 µM 0.392239662639189 0.336093833411108 no 1117 0.347440570414228 1741 762646 SGTC_231 b-estradiol 524 µM 0.390738033086333 0.336657196406839 no 1118 0.347995441491873 1592 450 A steroid. SGTC_1797 st048695 56.8 µM 0.389978448939939 0.336942307664353 no 1119 0.348276241521029 1733 592262 YIL048W NEO1 SGTC_1398 3558-0053 112 µM 0.389032220047854 0.33729760742954 no 1120 0.348626155982893 1622 4532369 SGTC_209 4077-0173 175.592 µM 0.388086447917038 0.337652880734085 no 1121 0.348976030273636 1651 15993494 SGTC_3258 9138477 49.47 µM 0.385178928012185 0.338745977373886 no 1122 0.350052427110171 1690 4970355 SGTC_1811 st050069 61.5 µM 0.385025926013683 0.338803536972268 no 1123 0.350109103658176 1707 3877702 SGTC_2430 5571206 200 µM 0.384043637857247 0.339173164972725 no 1124 0.350473052253823 1792 1731771 SGTC_101 0490-5701 117.494 µM 0.383519513933886 0.339370452426593 no 1125 0.350667302150892 1744 4661669 SGTC_1293 1000-1278 195 µM 0.382849608835569 0.339622678028225 no 1126 0.350915638060731 1707 678847 SGTC_128 0906-2981 13.371 µM 0.38128103288195 0.340213542581698 no 1127 0.351497363088592 1732 6740226 SGTC_558 k064-0027 21.3 µM 0.37965036093278 0.340828214199348 no 1128 0.352102486090548 1724 5088526 SGTC_939 1165-0479 45.3 µM 0.379604466658686 0.340845519884658 no 1129 0.352119522339103 1716 1377347 SGTC_743 1275-0778 158 µM 0.37653176133339 0.342004927348788 no 1130 0.35326080385436 1771 2849257 YMR203W TOM40 SGTC_765 1319-0117 244 µM 0.371778912460633 0.343801229104672 no 1131 0.355028732757429 1607 3487746 YGL099W LSG1 SGTC_1997 st073024 93.8 µM 0.370739334116835 0.344194601704371 no 1132 0.355415845211931 1759 686268 SGTC_2649 anisomycin 9.56 µM 0.370331970942991 0.344348792435827 no 1133 0.355567577579997 1676 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2670 beta-carotene 100 µM 0.370088963650905 0.344440785267599 no 1134 0.355658102486344 1697 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_39 0986-0283 58.349 µM 0.369608465500564 0.344622709713708 no 1135 0.355837121281574 1813 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1519 esterone 74 µM 0.369097153724196 0.344816340174845 no 1136 0.356027655202712 1588 698 A steroid. SGTC_1503 4585-0012 61.3 µM 0.367726309689742 0.345335670429043 no 1137 0.356538660373829 1739 2922052 SGTC_2014 4013930 200 µM 0.366147707601991 0.345934068586294 no 1138 0.357127429995582 1738 64556 SGTC_1984 st072354 53.1 µM 0.366052143765014 0.345970306189887 no 1139 0.357163083283234 1707 5762938 SGTC_34 0469-0683 81.75 µM 0.36261977856278 0.347272784793457 no 1140 0.358444466691038 1753 3690923 SGTC_2453 5731132 22.18 µM 0.362497597758698 0.347319182080524 no 1141 0.358490109177957 1821 1362040 SGTC_1045 1348-1485 165 µM 0.360742474366507 0.347985929851703 no 1142 0.359145984866854 1671 6810614 SGTC_2989 9073649 71.4286 µM 0.360676360624637 0.348011054776459 no 1143 0.359170699177275 1814 21367202 SGTC_2112 5488546 200 µM 0.36019246037703 0.348194969642485 no 1144 0.359351606299314 1664 600757 SGTC_384 k007-0144 5.16 µM 0.358927665246997 0.348675845986468 no 1145 0.359824601444648 1706 6824886 SGTC_1718 roemerine 11.9335 µM 0.358386504984005 0.348881669992025 no 1146 0.360027044668972 1680 235224 An aporphine alkaloid with mutagenic activity. SGTC_2915 7971052 15.16 µM 0.358217953478709 0.348945785681092 no 1147 0.360090106304795 1697 5741558 SGTC_1178 0988-0033 191 µM 0.358115126899941 0.348984902234738 no 1148 0.360128579574204 1730 5392207 SGTC_517 1365-0151 113 µM 0.358002078163686 0.349027909280685 no 1149 0.360170879168925 1708 768657 SGTC_931 2812-0076 566 µM 0.355588595677882 0.349946530459349 no 1150 0.361074342746903 1663 3450959 SGTC_1741 st038134 10.228 µM 0.353906700086329 0.350587214634669 no 1151 0.361704402827926 1807 1272587 SGTC_2783 7738165 71.43 µM 0.353682225783309 0.350672755792608 no 1152 0.361788522246709 1582 17201110 SGTC_153 4077-0274 519.67 µM 0.35342367198177 0.35077129311954 no 1153 0.361885420880784 1828 3121976 SGTC_3146 9095609 49.47 µM 0.352626481279948 0.351075173291152 no 1154 0.362184241069206 1760 17173999 SGTC_3219 9131112 49.47 µM 0.351264072939752 0.351594728526604 no 1155 0.362695122694855 1709 17612988 YMR079W SEC14 SGTC_1052 3253-3998 198 µM 0.348437815228517 0.352673407100606 no 1156 0.363755703625958 1671 5450317 SGTC_1008 4106-0037 6 µM 0.346841285128207 0.35328326852396 no 1157 0.364355279549316 1716 2905394 SGTC_1216 1165-0504 9.65 µM 0.346517967176796 0.353406819282264 no 1158 0.364476741893473 1823 6304004 SGTC_250 brefeldin a 552.239 µM 0.345256853070647 0.353888881312657 no 1159 0.364950640400564 1697 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3064 1327-0027 10 µM 0.345111066659003 0.353944623427743 no 1160 0.365005436997897 1697 16000455 YPR107C YTH1 SGTC_1187 1391-0724 117 µM 0.344797328844722 0.354064593162559 no 1161 0.365123370675785 1740 6997986 SGTC_264 promethazine 12.5 mM 0.342699677923323 0.354867082515559 no 1162 0.36591220252327 1753 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_134 0269-0018 6.916 µM 0.342449552785524 0.354962814888341 no 1163 0.366006301213237 1671 4378915 SGTC_1445 4239-0156 97.7 µM 0.341656417538624 0.355266438348909 no 1164 0.366304737086364 1838 4008346 SGTC_958 1222-0007 33 µM 0.341184664125497 0.355447075870435 no 1165 0.366482283824023 1794 7312461 SGTC_838 0109-0203 71.4 µM 0.340447458775452 0.355729421723489 no 1166 0.366759791927902 1707 759422 SGTC_1072 oxiconazole 14.9 nM 0.338723801885966 0.356389882149915 no 1167 0.367408904118422 1744 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1801 st050089 28.441 µM 0.338575981161949 0.35644654329353 no 1168 0.367464589619363 1706 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1706 st031321 9.9705 µM 0.337720981360625 0.356774335298898 no 1169 0.367786730986861 1813 6103185 SGTC_3103 9120822 49.47 µM 0.33626063784485 0.357334450069277 no 1170 0.36833716493126 1826 17141819 SGTC_1938 st074717 56.4 µM 0.335061073923774 0.357794772938771 no 1171 0.368789507903001 1690 17250979 SGTC_3297 9117502 71.43 µM 0.334198922332376 0.358125744406407 no 1172 0.369114728573073 1751 7453720 SGTC_1073 triclabendazole 3.09 µM 0.333809020565206 0.358275458874388 no 1173 0.369261838037119 1747 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3267 9137951 49.47 µM 0.333589638683147 0.358359706704005 no 1174 0.369344618974388 1759 16643986 SGTC_526 4469-0568 170 µM 0.332866674676803 0.358637390758987 no 1175 0.369617463023257 1683 2901964 SGTC_1044 1222-0021 1.78 µM 0.332386388606257 0.358821905706378 no 1176 0.369798757592024 1774 4306703 SGTC_600 1495-0418 41.6 µM 0.331828874283882 0.359036131307257 no 1177 0.370009239964667 1732 5377768 SGTC_415 dibenzyl ketone 100 µM 0.331736803024504 0.359071514075392 no 1178 0.370044004034459 1845 7593 SGTC_2861 9024595 19.48 µM 0.331202497170378 0.359276870413106 no 1179 0.370245767051813 1767 16482810 SGTC_3317 9138495 8.753 µM 0.329894945118415 0.359779589363545 no 1180 0.370739671552602 1733 17020139 SGTC_184 1494-0393 24.714 µM 0.328212293623822 0.360426881095134 no 1181 0.371375576639786 1678 3090647 SGTC_1944 st076371 56.9 µM 0.32616106813644 0.361216499120939 no 1182 0.37215124762366 1679 24208455 SGTC_3145 9085516 49.47 µM 0.32480402089484 0.361739219076446 no 1183 0.372664700588149 1684 25236195 SGTC_380 3970-0968 6 µM 0.324613384649403 0.361812670797832 no 1184 0.372736847950932 1732 2891601 SGTC_2508 celastrol 40.54 µM 0.323008986279024 0.36243104340279 no 1185 0.373344218246418 1736 122724 Celastrol is a natural product and antioxidant. SGTC_188 3229-0966 278.469 µM 0.321722879022095 0.362926998573257 no 1186 0.373831321837235 1871 5722370 SGTC_716 1683-5115 658 µM 0.32103782156595 0.363191267822709 no 1187 0.374090864604855 1848 723597 SGTC_2667 digitoxin 100 µM 0.320913840971062 0.363239101810847 no 1188 0.374137842340727 1855 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_439 amiodarone 34.4 µM 0.320171152054512 0.363525689456585 no 1189 0.374419295200163 1809 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_591 4299-0174 154 µM 0.319077822606669 0.363947720695076 no 1190 0.374833750187887 1802 5509088 SGTC_247 mechlorethamine 29.705 µM 0.31840383411093 0.36420796628133 no 1191 0.37508931515049 1773 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3217 9129673 49.47 µM 0.317768717064751 0.364453259842124 no 1192 0.375330190919411 1761 17248312 SGTC_862 0452-0056 10.2 µM 0.315454939012515 0.365347351176376 no 1193 0.376208129580598 1799 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3172 9105863 49.47 µM 0.3149379325529 0.365547233353028 no 1194 0.37640438999633 1789 2348785 SGTC_1158 4092-0494 91.8 µM 0.31485913786186 0.365577699728596 no 1195 0.376434303994733 1841 1148199 SGTC_866 0495-0101 262 µM 0.314169196316024 0.365844505405695 no 1196 0.376696268428639 1675 635694 SGTC_255 tunicamycin 200.472 nM 0.313771455046413 0.365998344498913 no 1197 0.376847312928684 1881 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1619 st003326 88.7 µM 0.313462739266212 0.366117765004388 no 1198 0.376964562490466 1854 2849032 SGTC_2373 9071805 200 µM 0.313390810169107 0.366145591195806 no 1199 0.376991882630665 1921 10149009 SGTC_2024 5144227 134 µM 0.311930940303771 0.366710502327343 no 1200 0.377546503938496 1823 3475211 SGTC_1363 1636-0063 10.4 µM 0.310557115646887 0.367242381249003 no 1201 0.378068666428438 1765 6072185 SGTC_2085 5307070 144.047 µM 0.309936111460367 0.367482887940843 no 1202 0.378304770525059 1716 2840351 SGTC_2458 5808907 16.39 µM 0.308967755371725 0.367858023131169 no 1203 0.378673027524223 1887 2731747 SGTC_2612 dictamnine 15.46 µM 0.308243445109922 0.368138698913337 no 1204 0.378948548173492 1767 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_614 0462-0418 107 µM 0.308045538140197 0.368215401634364 no 1205 0.37902384078595 1775 5188303 SGTC_1654 st012436 41.8 µM 0.306590768639198 0.368779387091887 no 1206 0.379577440513267 1870 4323132 SGTC_1664 st014217 9.02 µM 0.306397923311967 0.368854170672169 no 1207 0.379650844667237 1834 3982782 SGTC_2010 4012422 159 µM 0.306085760862846 0.368975234819081 no 1208 0.379769674578407 1808 952393 SGTC_831 k061-1017 217 µM 0.304846048833689 0.369456153351257 no 1209 0.380241703895574 1881 1240153 SGTC_3018 9082602 49.47 µM 0.304817101278816 0.36946738535139 no 1210 0.380252728020676 1788 17332089 SGTC_2820 7989630 71.43 µM 0.302662745313855 0.370303613494209 no 1211 0.381073445902133 1927 2984098 SGTC_487 nimodipine 119 µM 0.301554451047323 0.370734044747941 no 1212 0.381495867572191 1890 4497 L-type voltage-gated calcium channels inhibitor SGTC_3015 9080845 49.47 µM 0.299817019267635 0.371409141381287 no 1213 0.382158366347922 1877 5296973 SGTC_2289 7946404 165.07 µM 0.29936727841137 0.371583957292387 no 1214 0.382329913003401 1735 1246120 YPR165W RHO1 SGTC_3160 9100216 49.47 µM 0.299273011448157 0.371620602563793 no 1215 0.382365872599697 1864 17191039 SGTC_2587 piperic acid 92.2 µM 0.298300371919758 0.371998773628499 no 1216 0.382736960226835 1743 5370536 SGTC_1780 st038448 24.544 µM 0.298204120701569 0.372036203696532 no 1217 0.382773688465123 1866 728868 YDL195W SEC31 SGTC_1822 st052468 42 µM 0.297853699852165 0.372172485184756 no 1218 0.382907413498962 1778 2873678 SGTC_1760 st045453 10.4495 µM 0.296111794100018 0.37285016367253 no 1219 0.383572353643388 1914 3323419 YIL048W NEO1 SGTC_1218 1348-1416 30.7 µM 0.295449594642471 0.373107891986146 no 1220 0.383825226076972 1759 6787668 SGTC_1053 3366-3204 134 µM 0.295192653331656 0.373207908954456 no 1221 0.383923356935334 1712 3632071 YPR165W RHO1 SGTC_2092 5303694 80.6725 µM 0.295161287875898 0.373220118856293 no 1222 0.383935336519687 1751 1963699 SGTC_1773 st048542 73.5835 µM 0.294913569096458 0.37331655495736 no 1223 0.384029953037833 1717 3237138 SGTC_2753 fluvastatin 17.09 µM 0.294805838367002 0.373358496650174 no 1224 0.384071103090704 1805 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2037 5169046 200 µM 0.293723029957988 0.373780138522536 no 1225 0.384484777398166 1838 5718022 SGTC_2690 usnic acid 100 µM 0.292949837245174 0.374081309609554 no 1226 0.384780247199055 1916 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2182 6325192 200 µM 0.292461751593941 0.374271466470766 no 1227 0.384966799945517 1883 736248 SGTC_780 0109-0199 192 µM 0.291830956319656 0.374517267929095 no 1228 0.38520793762849 1925 610414 SGTC_1671 st016596 74.5 µM 0.291225401259963 0.374753282039184 no 1229 0.385439468357811 1786 2829167 SGTC_119 0121-0043 24.815 µM 0.289319136340569 0.375496551683819 no 1230 0.386168584765083 1891 1092378 SGTC_1952 st077036 64.1 µM 0.286016582839287 0.37678533969713 no 1231 0.38743271030298 1890 2937007 SGTC_1153 4055-0057 267 µM 0.285751508733669 0.37688884194694 no 1232 0.387534225250214 1768 882706 SGTC_2943 9068529 45.32 µM 0.285655861910355 0.37692619088869 no 1233 0.387570856828104 1839 3270634 SGTC_185 k048-0037 25.491 µM 0.283531241208737 0.377756126222851 no 1234 0.38838481837176 1938 6827589 SGTC_91 0417-1751 58.384 µM 0.283038256381369 0.377948780515158 no 1235 0.388573755580405 1860 6795624 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.282784874693687 0.378047811745757 no 1236 0.38867087477032 1863 66535 A nucleotide analog. SGTC_2419 paclitaxel 166.5 µM 0.282534015688153 0.378145864910456 no 1237 0.388767033891709 1831 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.282091638133939 0.378318795979453 no 1238 0.388936622390222 1790 442882 SGTC_2173 5763948 167 µM 0.281906092012393 0.378391335600157 no 1239 0.38900775908256 1876 2867177 SGTC_3344 9148862 3.898 µM 0.281680250640982 0.378479634510925 no 1240 0.389094349627221 1904 4905352 SGTC_1730 st033808 45.1 µM 0.281385069602648 0.378595053242308 no 1241 0.389207534214472 1794 1045166 SGTC_3179 9107801 49.47 µM 0.278282396597535 0.37980888270263 no 1242 0.390397794056199 1773 4818259 SGTC_3107 9121808 49.47 µM 0.277145245944969 0.380254056845361 no 1243 0.390834290364978 1931 662681 SGTC_3060 1327-0027 12.5 µM 0.276511004117596 0.380502420144386 no 1244 0.391077804468003 1928 16000455 YPR107C YTH1 SGTC_1508 1080-0625 72.9 µM 0.27645166291194 0.380525660139629 no 1245 0.391100590425232 1851 767111 SGTC_2276 7947513 42.08 µM 0.2762348652799 0.380610568987518 no 1246 0.391183839999284 1667 2105100 SGTC_1105 epirubicin 18.1 µM 0.273738418728157 0.381588716375325 no 1247 0.392142825562287 1778 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1960 st011366 51.8 µM 0.273046417390873 0.381859987694339 no 1248 0.392408767399909 1821 3972846 SGTC_2771 fluoxetine 41.05 µM 0.273003718746562 0.381876727884003 no 1249 0.392425178489377 1904 3386 A selective serotonin reuptake inhibitor. SGTC_2150 5556613 200 µM 0.272781059658935 0.381964025928491 no 1250 0.392510759907667 1858 743190 SGTC_1790 st045711 43.5 µM 0.271690483097395 0.382391695368516 no 1251 0.392930009762403 1940 585119 SGTC_3327 9140648 26.9345 µM 0.271625769559261 0.382417077288208 no 1252 0.392954891468093 1930 8029710 SGTC_2738 aclarubicin 5.55 µM 0.271269691313787 0.382556747198957 no 1253 0.393091807800113 1896 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_144 4161-2749 112.381 µM 0.270543256802922 0.382841734861974 no 1254 0.393371171529743 1877 797501 YMR168C CEP3 SGTC_348 k064-0012 10.7 µM 0.269169332920372 0.383380912552822 no 1255 0.393899689209122 1787 5066323 SGTC_1001 4048-4355 44.4 µM 0.265416311172598 0.384854883502134 no 1256 0.395344386063779 1810 21824233 SGTC_1959 st077091 55.8 µM 0.265035324497079 0.385004606623586 no 1257 0.395491124769947 1815 821356 YKL052C ASK1 SGTC_2969 9091408 28.7 µM 0.264811215181075 0.385092686865572 no 1258 0.395577448389001 1728 4286311 SGTC_2107 5363541 170.161 µM 0.262749283676233 0.385903352209215 no 1259 0.396371914029367 1891 244052 SGTC_2106 5357045 167.29 µM 0.262728147261516 0.385911664751874 no 1260 0.396380060159788 1906 668842 SGTC_2815 7968870 71.43 µM 0.260252272468149 0.38688573986738 no 1261 0.397334592694638 1804 2977326 YHR190W ERG9 SGTC_422 cantharidin 155 µM 0.26020830325208 0.386903044989259 no 1262 0.397351549874242 1750 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.258253977535132 0.387672442577238 no 1263 0.398105451159014 1891 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2476 5806916 10.51 µM 0.257899391274221 0.387812086863025 no 1264 0.398242277333652 1889 2870194 SGTC_3319 9138450 16.7555 µM 0.257331639880085 0.388035710729567 no 1265 0.398461384776003 1845 2029690 SGTC_1303 1160-0052 261 µM 0.256951229098866 0.388185566332543 no 1266 0.398608211372463 1937 3562476 SGTC_1230 0170-0365 3.77 µM 0.256767239489027 0.388258051520281 no 1267 0.398679230725658 1962 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_585 0kpi-0023 191 µM 0.256608890185438 0.388320438480259 no 1268 0.398740355695814 1936 64601 SGTC_408 cantharidin 100 µM 0.255820079767959 0.388631259406476 no 1269 0.39904488414786 1878 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1481 3346-2004 36 µM 0.255682801623861 0.388685359441529 no 1270 0.399097888084282 1916 2770522 SGTC_1929 genistein trimethyl ether 50.5 µM 0.254064922938072 0.389323112722812 no 1271 0.399722700918043 2023 136420 SGTC_3020 9089140 49.47 µM 0.251888064185816 0.390181681273154 no 1272 0.400563792799086 1840 17217859 SGTC_2288 7946289 167.31 µM 0.251741120482254 0.390239656269382 no 1273 0.400620585380936 1960 1246052 SGTC_2154 5570129 200 µM 0.250076204440434 0.390896700512997 no 1274 0.401264208770307 1941 673366 SGTC_353 1988-1175 58.3 µM 0.249639996500583 0.391068897666534 no 1275 0.401432882453564 1799 2788357 SGTC_2177 5811945 192 µM 0.249520318583701 0.391116145375664 no 1276 0.401479162941577 1943 5343475 SGTC_3261 9137475 49.47 µM 0.247980839998275 0.391724060010658 no 1277 0.402074615670994 1920 17027690 SGTC_1388 3346-4487 254 µM 0.24400075747485 0.393296951203445 no 1278 0.403615116633369 1925 3345614 SGTC_938 3126-1755 342 µM 0.243542279287454 0.393478249925052 no 1279 0.403792668344837 2011 1777771 SGTC_192 3455-0609 60.9 µM 0.243106182927528 0.393650719504454 no 1280 0.403961570797745 1896 3769639 SGTC_833 3852-0053 558 µM 0.242624041092972 0.39384142366551 no 1281 0.404148327751638 1917 3123681 SGTC_647 0140-0236 81 µM 0.241408679436947 0.394322255106735 no 1282 0.404619193218534 1907 990837 SGTC_2053 5265679 138 µM 0.240301269114168 0.394760518230922 no 1283 0.405048355611347 1860 764595 SGTC_3343 9148379 18.9835 µM 0.238803031289809 0.395353665215947 no 1284 0.405629159799812 1994 1955036 SGTC_515 4092-1064 102 µM 0.23806122773859 0.395647432434169 no 1285 0.405916803038394 2017 717353 SGTC_3061 glucosamine 200 µM 0.237904983834276 0.395709315326309 no 1286 0.405977394971187 2008 91431 and experimental redox chemotherapeutic SGTC_887 0885-0007 9.62 µM 0.237768650827821 0.395763314337517 no 1287 0.40603026722824 1951 5719458 SGTC_453 enantio-paf c16 10 µM 0.236510310688133 0.396261814188745 no 1288 0.406518353716352 1939 13871343 A lipid and platelet activating factor SGTC_896 0964-0007 44.5 µM 0.236229133769598 0.396373227522857 no 1289 0.406627436842352 2009 6756758 SGTC_784 4579-0127 173 µM 0.235638650603862 0.396607227673063 no 1290 0.406856539497548 2011 1948547 SGTC_208 k072-0098 12.366 µM 0.233557515643487 0.397432248509162 no 1291 0.407664256573654 1983 5948901 SGTC_2119 5528445 120.635 µM 0.233472382059481 0.397466007671339 no 1292 0.407697306470668 1992 791935 SGTC_1116 jasmonic acid  1.58368 µM 0.232431622950586 0.397878775856083 no 1293 0.408101394902489 1961 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2103 5378138 10 µM 0.23200630882405 0.39804748965052 no 1294 0.408266556876453 1937 244142 SGTC_2091 4-phenylthiadiazole 200 µM 0.231392593461213 0.398290972125749 no 1295 0.408504909306369 1882 270010 SGTC_673 1082-0474 110 µM 0.230263633558542 0.398738973611509 no 1296 0.408943458791009 1847 3098046 SGTC_3074 9116018 49.47 µM 0.228790933194604 0.3993235810213 no 1297 0.409515707081302 1903 17027303 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.22875814715257 0.399336598438321 no 1298 0.409528448977137 1853 5282362 SGTC_438 sphingosine 6.67 µM 0.228370864685085 0.399490374088911 no 1299 0.409678968818398 1724 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1837 st055472 66.5 µM 0.228355461969671 0.399496490264349 no 1300 0.409684955458991 1936 676091 SGTC_3049 9092223 49.47 µM 0.22808712012885 0.399603048535101 no 1301 0.409789256430683 1929 8623917 SGTC_7 0192-1582 4.227 µM 0.22768885003849 0.399761214965505 no 1302 0.409944070584171 1939 252616 SGTC_2397 5161689 200 µM 0.226768743669284 0.400126682966626 no 1303 0.410301784751547 1957 2259942 SGTC_1288 0973-0013 65.5 µM 0.226393326631222 0.400275824476525 no 1304 0.410447758892319 1933 4315430 SGTC_3004 9076122 71.4286 µM 0.226199428207412 0.400352859985102 no 1305 0.410523157655649 1982 44782551 SGTC_1828 st055811 49 µM 0.225120870153914 0.400781439915386 no 1306 0.410942622811665 2023 5877589 SGTC_2507 purpurin 79.67 µM 0.224973130560461 0.40084015559576 no 1307 0.411000088589934 1798 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_481 bay k-8644 50 µM 0.224509686358452 0.401024355292097 no 1308 0.411180365327595 1860 2303 A calcium channel antagonist. SGTC_985 1493-0307 8.71 µM 0.221922385145837 0.402053102600085 no 1309 0.412187152086028 2028 3278274 SGTC_369 0957-0393 4.5 µM 0.220947352757699 0.402440965699504 no 1310 0.412566713122408 1840 6997992 SGTC_540 1187-0821 17.3 µM 0.220803222133231 0.402498308313225 no 1311 0.412622827301225 1834 847520 SGTC_3260 9137109 49.47 µM 0.219919018628856 0.402850136047867 no 1312 0.412967112082979 2030 17478346 SGTC_1868 st057644 42.7 µM 0.219881181082253 0.402865193500411 no 1313 0.412981846489606 1940 688665 SGTC_2203 7227154 166.4 µM 0.218766540981588 0.403308829095131 no 1314 0.413415955983182 1987 896304 SGTC_1267 0828-0272 9.49 µM 0.217675987739813 0.403742998399826 no 1315 0.413840787036043 2027 745334 SGTC_1717 st033143 58.0435 µM 0.217273202698523 0.403903384561373 no 1316 0.413997719709817 2019 674616 SGTC_46 0329-0187a 2.197 µM 0.216569922898432 0.404183464336133 no 1317 0.414271763739635 1957 46494817 SGTC_3165 9101544 49.47 µM 0.216542054631644 0.40419456383041 no 1318 0.414282623908558 1985 5002184 SGTC_693 4161-2696 114 µM 0.216506734068839 0.404208631568313 no 1319 0.414296388306098 1994 805759 SGTC_1129 3453-1384 223 µM 0.216227958989146 0.404319668537546 no 1320 0.414405030443752 1941 1084452 SGTC_2390 9097792 176.6 µM 0.215371591501686 0.404660810503633 no 1321 0.414738808496033 1842 4497149 SGTC_2250 alverine citrate 130 µM 0.213388282494903 0.405451158035235 no 1322 0.415512059628444 1862 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3302 9125395 16.351 µM 0.212799864191192 0.405685716730079 no 1323 0.415741534838577 1930 17599668 SGTC_2081 5214970 32.255 µM 0.212729596922384 0.405713729339001 no 1324 0.415768940048779 2020 2063512 SGTC_1408 3909-7976 48.8 µM 0.212243450579034 0.405907548687258 no 1325 0.415958555085178 1953 24152374 SGTC_1126 isoteolin 1.0172 µM 0.212208070144615 0.405921655243536 no 1326 0.415972355526167 1863 133323 SGTC_483 fpl-64176 144 µM 0.211184172448951 0.406329947015797 no 1327 0.416371780399271 2008 3423 SGTC_166 k072-0058 166.424 µM 0.211000702433029 0.40640311871182 no 1328 0.416443361616479 2078 5846229 SGTC_186 3455-3465 67.277 µM 0.209188639423429 0.407125982676369 no 1329 0.417150490333483 1963 755278 SGTC_1237 0330-0133 46.1 µM 0.208324971152781 0.407470626728533 no 1330 0.417487617593172 1915 X1237 YHR072W ERG7 SGTC_1704 st028805 70.8 µM 0.205675661897229 0.40852827089324 no 1331 0.418522135542823 1931 2876101 SGTC_731 3966-0296 387 µM 0.205663795969892 0.408533009455346 no 1332 0.418526770293899 1937 660956 SGTC_1897 st060201 15 µM 0.205642686131199 0.40854143953174 no 1333 0.418535015682277 1866 611878 SGTC_800 3448-7362 155 µM 0.205027780899106 0.408787016480416 no 1334 0.418775210019574 2074 15991913 SGTC_1948 st076329 66.6 µM 0.204863767082334 0.408852525331892 no 1335 0.418839282231168 2047 24208413 SGTC_863 0466-0191 129 µM 0.204535334540675 0.408983712412286 no 1336 0.418967591302558 2057 765160 YPR165W RHO1 SGTC_1683 st010134 710 nM 0.204350698740246 0.409057466682287 no 1337 0.419039726942177 1858 3818134 SGTC_381 3461-2219 42.7 µM 0.204255056132311 0.409095673164901 no 1338 0.419077094767326 2036 2883159 SGTC_1010 4112-3296 15.2 µM 0.202823150919514 0.409667781346787 no 1339 0.419636631095144 2100 704384 SGTC_2262 9014885 67.46 µM 0.202453256510923 0.409815601510017 no 1340 0.419781198797067 2055 6457424 SGTC_2834 9001755 58.44 µM 0.201932522164131 0.41002372325783 no 1341 0.419984738379539 1901 2989575 SGTC_2497 7-hydroxyflavone 100 µM 0.201728721664564 0.410105183050356 no 1342 0.420064403769474 2042 5281894 SGTC_1429 4049-0205 9.46 µM 0.201562140573355 0.410171768993046 no 1343 0.420129522566666 2035 22774478 SGTC_63 0099-0242 26.702 µM 0.201383311340789 0.410243253656315 no 1344 0.420199431761154 2063 3898502 YLR359W ADE13 SGTC_2679 rapamycin 1 nM 0.200615910196214 0.410550046130028 no 1345 0.420499458227163 1972 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2429 5902844 64.44 µM 0.20027747123012 0.410685365037614 no 1346 0.420631790475556 2058 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2522 biochanin a 4.94 µM 0.200058690513096 0.410772846343655 no 1347 0.420717340199256 1999 5280373 A possible chelator. SGTC_2418 pentamidine 31.67 µM 0.199958209921063 0.410813025839417 no 1348 0.420756632334233 2072 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_978 1416-0512 87.4 µM 0.199468388006834 0.41100890588818 no 1349 0.420948184588762 1954 6814003 SGTC_1367 1812-0510 76.9 µM 0.198517044243783 0.411389412139245 no 1350 0.42132027536722 2003 1142582 YDR527W RBA50 SGTC_721 1187-1332 279 µM 0.197762161142386 0.411691399917711 no 1351 0.421615576226198 1959 25730 SGTC_943 3253-1379 105 µM 0.19704381535 0.411978819684059 no 1352 0.421896625086518 2001 668464 SGTC_3245 9134821 49.47 µM 0.196797286485749 0.412077470074899 no 1353 0.42199308733223 1902 17014901 SGTC_343 4130-2827 29.8 µM 0.195407554090269 0.412633685781744 no 1354 0.422536951647969 1901 1118244 SGTC_1615 st002656 86.5 µM 0.194870600312494 0.412848639053744 no 1355 0.422747125244927 2060 1584458 SGTC_2296 7971656 126.45 µM 0.191678798513312 0.414126918058909 no 1356 0.423996907184962 1938 666570 SGTC_1210 3013-0140 750 nM 0.188723468217685 0.415311304992835 no 1357 0.425154778562749 2102 905973 SGTC_961 1252-1571 372 µM 0.185469665412551 0.416616198868302 no 1358 0.426430335484545 2076 6813498 SGTC_317 4495-0002 170 µM 0.184597624057707 0.416966076146548 no 1359 0.426772324821956 1951 15991618 SGTC_1697 st025554 27.742 µM 0.183761827334196 0.41730147322029 no 1360 0.427100151740853 1966 1269519 SGTC_2608 thymoquinone 42.66 µM 0.183404510124495 0.41744487951054 no 1361 0.427240318661338 2094 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_890 0929-0006 47.2 µM 0.181068349582072 0.418382747879872 no 1362 0.428156963652494 1918 1378169 SGTC_2720 fluspirilene 36.88 µM 0.180858826663024 0.418466885117315 no 1363 0.428239193692632 2051 3396 An atypical antipsychotic. SGTC_1291 0993-0025 5.79 µM 0.177205803244068 0.419934410588012 no 1364 0.429673368737631 2071 4353356 SGTC_2716 st080858 38.6235 µM 0.17500369958161 0.420819599020919 no 1365 0.430538363301139 2083 5296050 SGTC_2090 5301565 104.445 µM 0.173975686020115 0.421232971144984 no 1366 0.4309422852792 1989 2056344 SGTC_1467 k284-1082 293 µM 0.173486445816616 0.421429728902426 no 1367 0.431134540506486 2130 3334705 SGTC_493 zm226600 134 µM 0.173190716133042 0.421548672041891 no 1368 0.431250760412428 2047 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2433 5607874 27.82 µM 0.172567314845455 0.421799428869975 no 1369 0.431495772686329 2003 2252428 SGTC_928 2764-0428 58.7 µM 0.172091557301612 0.421990818843939 no 1370 0.431682775021284 2012 662578 SGTC_3298 9116858 71.43 µM 0.171971764317902 0.422039012632225 no 1371 0.431729863536704 2061 2506942 SGTC_1443 4112-3303 14 µM 0.171219657033679 0.422341618762692 no 1372 0.432025525823185 2008 704433 SGTC_3050 9093513 49.47 µM 0.171018524147031 0.422422551223646 no 1373 0.432104600004098 2049 25236664 SGTC_678 1218-2179 85.9 µM 0.170837434938721 0.422495421250638 no 1374 0.432175796460804 2107 6820081 YOR116C RPO31 SGTC_530 4358-1714 28 µM 0.170528942226319 0.422619564364632 no 1375 0.432297087544605 2045 1564641 SGTC_2786 7743617 45.45 µM 0.170291769933918 0.422715012062931 no 1376 0.43239034168597 1932 583674 SGTC_3269 9137823 49.47 µM 0.169216898828409 0.42314764035829 no 1377 0.432813019062392 1947 17682936 SGTC_877 0771-0151 33.1 µM 0.168337016399687 0.423501856056131 no 1378 0.433159077238362 2025 6166523 SGTC_3284 9108171 64.8615 µM 0.166682776093922 0.424167973442041 no 1379 0.433809829309119 2013 8687505 SGTC_294 k038-0071 157 µM 0.166357652515933 0.424298917365018 no 1380 0.433937748957739 2000 24152826 SGTC_227 fluconazole 33.516 µM 0.165611616011764 0.424599416053759 no 1381 0.434231302640211 1977 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1456 k015-0012 13 µM 0.165422266926439 0.424675691623735 no 1382 0.434305814317864 2158 2989616 SGTC_1925 st057770 10.1 µM 0.164745180457771 0.424948465701295 no 1383 0.434572276977099 1852 5989122 SGTC_969 1313-0238 134 µM 0.163227424596474 0.425560045984741 no 1384 0.43516968703127 1998 5212874 SGTC_1373 2887-0003 58.5 µM 0.163170437946533 0.425583012274802 no 1385 0.435192120669742 2012 776948 SGTC_2195 6536160 144.242 µM 0.162759502446658 0.425748631583733 no 1386 0.435353897684795 1991 3834386 SGTC_1159 4092-0538 61.2 µM 0.161805209338347 0.426133290762184 no 1387 0.435729625322839 2068 717301 SGTC_410 α-linolenic acid 100 µM 0.161283260162846 0.42634370927856 no 1388 0.435935153554337 2085 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2404 5161160 200 µM 0.160669351997336 0.42659122696078 no 1389 0.436176914670498 2019 2831543 SGTC_1681 tripelennamine 100 µM 0.159566754696336 0.427035848605193 no 1390 0.436611184635651 2154 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2394 5221648 200 µM 0.159553765458601 0.427041087060496 no 1391 0.436616301044911 2062 788586 SGTC_2855 9016525 58.44 µM 0.159426588970603 0.427092376996697 no 1392 0.43666639591948 2083 43811474 SGTC_1290 0986-0249 10.2 µM 0.159235860280269 0.427169299675543 no 1393 0.436741525938123 2127 53329 SGTC_954 1189-0853 2.85 µM 0.158916197094091 0.42729822906081 no 1394 0.436867449713867 2135 2828194 SGTC_984 1492-0255 2.91 µM 0.158623245202973 0.427416391829815 no 1395 0.436982856822548 2035 1585198 SGTC_1729 st035615 45.989 µM 0.158522811918964 0.42745690330814 no 1396 0.437022423307885 1972 17385451 SGTC_1202 1988-0068 29.6 µM 0.157858942653843 0.427724705519857 no 1397 0.437283975672951 1952 2850480 SGTC_1387 3342-1166 1.8 µM 0.157473227295682 0.427880316858315 no 1398 0.437435953076195 2037 3418228 SGTC_2186 6124449 200 µM 0.156250430057327 0.428373710934708 no 1399 0.437917813705266 2090 3834182 YLR033W RSC58 SGTC_2332 7982454 138.89 µM 0.15540600368534 0.428714499208235 no 1400 0.438250625706046 2128 2981748 SGTC_471 1-acyl-paf 4 µM 0.15496585616048 0.428892152262864 no 1401 0.438424117461105 1977 16759367 SGTC_1930 st074634 34.3 µM 0.154913713447087 0.428913199144179 no 1402 0.438444671197537 2066 684253 YOR116C RPO31 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.154555799456074 0.429057672975836 no 1403 0.438585759047836 2111 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1177 0983-0204 23.6 µM 0.153870065198367 0.429334499685625 no 1404 0.43885609374398 2155 766818 SGTC_1215 3852-0577 11.2 µM 0.153414610922486 0.429518382997317 no 1405 0.439035661714793 2109 2884876 SGTC_1961 st076550 68.7 µM 0.153269858632099 0.429576827920228 no 1406 0.439092734562675 2052 1579337 SGTC_2992 9074591 71.4286 µM 0.150751820718053 0.430593752219104 no 1407 0.440085746646242 2159 17741321 SGTC_567 1080-0542 68.4 µM 0.150634532578162 0.430641130993388 no 1408 0.440132009571541 2141 5950415 SGTC_232 clozapine 119 µM 0.150096029887094 0.43085867301672 no 1409 0.44034442609704 2092 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2735 sertaconazole 140 nM 0.150059914164971 0.430873263643776 no 1410 0.440358672836267 2172 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2368 9071271 200 µM 0.149907662739957 0.430934773730918 no 1411 0.440418733022521 2003 27209959 SGTC_1488 4013-0813 75.9 µM 0.149655315875729 0.43103672640059 no 1412 0.440518281904865 2026 2910057 SGTC_2618 avocadyne 43.43 µM 0.149364091490419 0.431154391999524 no 1413 0.440633172340564 2059 3015189 SGTC_1049 3226-0134 66 µM 0.148951891914304 0.431320946565955 no 1414 0.440795797033187 2123 5702385 SGTC_59 0330-0160 1.33 µM 0.14880326988541 0.431381002214728 no 1415 0.440854435186377 2077 4293482 SGTC_99 0109-0120 622.8 µM 0.148512661746642 0.431498436631821 no 1416 0.440969097066585 2124 759414 SGTC_1685 st024049 53.0905 µM 0.14810835607569 0.431661826161427 no 1417 0.441128627492122 2071 1941139 SGTC_3294 9122953 26.2835 µM 0.148045398885268 0.431687269710989 no 1418 0.441153469921768 2126 16459826 SGTC_1637 st007924 17.4 µM 0.147945932752223 0.431727468579925 no 1419 0.441192718975008 2099 683336 SGTC_1294 1000-1494 117 µM 0.147664062152003 0.431841389377307 no 1420 0.441303947448551 1996 712797 YDL207W GLE1 SGTC_813 k007-0158 173 µM 0.145291586638875 0.43280047260575 no 1421 0.442240328565738 2121 6523916 SGTC_661 1304-0007 33.6 µM 0.14484307439557 0.432981830250729 no 1422 0.442417386178043 2023 3117130 SGTC_2868 9035608 32.47 µM 0.143413314151107 0.433560053329147 no 1423 0.442981884247225 2150 6462614 SGTC_2153 5569715 200 µM 0.142635199327726 0.433874798067211 no 1424 0.443289148327528 2158 2054701 SGTC_1908 st060353 56.5 µM 0.141182596101041 0.43446248307271 no 1425 0.443862847326939 2177 4227716 SGTC_1965 Pectolinarigenin 58.4 µM 0.139280574807573 0.435232209611371 no 1426 0.444614219657482 2057 5320438 An anti-inflammatory. SGTC_929 2805-0021 398 µM 0.138569724054817 0.435519946057739 no 1427 0.44489508457793 2063 3098024 SGTC_1957 st077035 62.4 µM 0.138210581402415 0.435665331942086 no 1428 0.445036996303638 2182 705593 SGTC_2927 9011802 47.9 µM 0.137674476271697 0.43588237084291 no 1429 0.445248846131739 2008 43912568 SGTC_1104 tacrolimus 29.8 µM 0.136578418986359 0.436326162998058 no 1430 0.445682017890194 2140 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_412 gemfibrozil 100 µM 0.136445706336251 0.436379903627963 no 1431 0.445734471542154 2161 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2990 9074105 71.4286 µM 0.136090041978565 0.436523932059179 no 1432 0.44587504981918 2170 6502001 SGTC_2437 5741531 144.16 µM 0.13602396940123 0.436550689476205 no 1433 0.445901166115685 2166 2262990 SGTC_715 0868-0130 184 µM 0.134665746358019 0.437100793324109 no 1434 0.446438078441526 2188 2876258 SGTC_2380 9035439 200 µM 0.134372484199984 0.437219585578359 no 1435 0.446554019357163 2135 6462575 SGTC_2201 6605497 169.863 µM 0.13351625854407 0.437566450865156 no 1436 0.446892553464535 2145 670741 SGTC_2880 9042983 58.44 µM 0.133450982643093 0.437592896735357 no 1437 0.446918363811209 2085 6464714 SGTC_621 3584-0052 32.1 µM 0.133427285846497 0.437602497321489 no 1438 0.446927733672943 2169 2273927 SGTC_2000 st075254 36.4 µM 0.13327347746556 0.437664812569842 no 1439 0.44698855118968 2154 17234175 SGTC_339 3091-4833 71.4 µM 0.133203545600114 0.43769314587776 no 1440 0.447016203426805 2095 3240077 SGTC_3237 9133362 49.47 µM 0.132820809564039 0.437848219296228 no 1441 0.447167548259254 2174 43845137 SGTC_1578 josamycin 24.2 µM 0.132055407990938 0.438158366178883 no 1442 0.447470233103055 1998 5282165 A P450 substrate. SGTC_1562 morin hydrate 59.1 µM 0.130832326622103 0.438654047378571 no 1443 0.4479539749189 2077 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1130 3454-2858 15.9 µM 0.129979732291531 0.438999637355654 no 1444 0.448291230965985 1989 715628 YIL048W NEO1 SGTC_619 1652-1634 108 µM 0.129953898177331 0.439010109664298 no 1445 0.448301450609004 2072 5400454 SGTC_1087 pterostilbene 9.05 µM 0.129931834595489 0.439019053555707 no 1446 0.448310178705125 2161 5281727 Similar to reservatol, lowers cholesterol. SGTC_1093 fluphenazine 7.97 µM 0.129470279047806 0.439206160983265 no 1447 0.448492770436797 2085 6602611 An atypical antipsychotic. SGTC_2748 diazoxide 86.69 µM 0.129251238613355 0.439294961317994 no 1448 0.448579426822329 2143 3019 A potassium channel activatior. SGTC_644 1498-1197 63.3 µM 0.129147123532854 0.439337171281215 no 1449 0.448620617505033 2134 6741615 SGTC_772 k072-0172 35.3 µM 0.126760063427987 0.440305112884445 no 1450 0.449565152727405 1971 5861980 SGTC_2019 4016004 108 µM 0.125271118737639 0.440909054011039 no 1451 0.450154457975699 2074 45595336 SGTC_2161 5662504 8.5105 µM 0.125236748161311 0.440922996926125 no 1452 0.450168062712848 2067 2859334 SGTC_109 0132-0036 33.701 µM 0.124941517648815 0.44104276441364 no 1453 0.450284924773109 2196 67274 A color developer. SGTC_2593 nobiletin 86.24 µM 0.124767509435125 0.441113357633398 no 1454 0.450353805033743 2064 72344 An anti-infammatory. SGTC_2235 salicylic acid 500 µM 0.124616381253336 0.441174670193965 no 1455 0.450413629564369 2191 338 A COX inhibitor and kinase inhibitor. SGTC_630 4356-0227 183 µM 0.124187961586685 0.441348487306689 no 1456 0.450583226855966 2176 779312 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.122111639882437 0.442191045631214 no 1457 0.451405301787898 2150 23665772 A membrane-active detergent. SGTC_1086 cerivastatin 2.18 µM 0.122066627908641 0.442209314118429 no 1458 0.451423125632178 2206 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1825 st052143 62.6 µM 0.121778144027837 0.442326400638208 no 1459 0.451537361821497 2179 674173 SGTC_3326 9140064 16.379 µM 0.121755560198025 0.442335566916101 no 1460 0.451546304919293 2156 1868434 SGTC_3039 9090270 49.47 µM 0.120461160029154 0.442860986806581 no 1461 0.452058922677808 2227 17173750 SGTC_1142 3253-1408 9.78 µM 0.12032223691828 0.442917384139344 no 1462 0.452113944782411 2220 256655 SGTC_1326 1431-2094 10.8 µM 0.119920038524111 0.443080667425529 no 1463 0.452273245289637 2131 616278 SGTC_1077 5-fluorocytosine 377 nM 0.119828721644736 0.443117741323235 no 1464 0.452309414643489 2125 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1719 st032227 49.2 µM 0.119763744418274 0.443144121842989 no 1465 0.452335151465879 2094 3125804 SGTC_1877 wortmannin 25 µM 0.119298003026324 0.443333218539938 no 1466 0.452519632778213 2203 312145 A covalent inhibitor of PI 3-kinase. SGTC_3056 9094900 49.47 µM 0.118894387740406 0.443497101718455 no 1467 0.452679514079013 2082 25236784 SGTC_2125 5246583 200 µM 0.118300306084307 0.44373833907167 no 1468 0.452914857441577 2191 835267 SGTC_1107 amlodipine 47 µM 0.11777754078512 0.443950634407148 no 1469 0.453121962763714 2152 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1924 st058459 75.1 µM 0.117677253373042 0.443991363032542 no 1470 0.453161695354629 2224 688683 SGTC_1412 3909-8563 178 µM 0.117437813542765 0.44408860649283 no 1471 0.453256560250657 2218 23767530 SGTC_2264 7948757 110.76 µM 0.117343195613914 0.444127034506474 no 1472 0.453294048149447 2144 2971411 SGTC_1655 st012546 55.1 µM 0.117094166329311 0.44422817747511 no 1473 0.453392716265282 2137 720985 YLR208W SEC13 SGTC_1946 st076057 65.1 µM 0.116652927950392 0.444407394870205 no 1474 0.453567546779938 2167 953009 SGTC_3151 9099821 49.47 µM 0.116041803960651 0.444655633317357 no 1475 0.453809705399565 2107 17174189 SGTC_2079 5212404 121 µM 0.115812991748535 0.444748582384724 no 1476 0.453900376938693 2198 758462 SGTC_1138 3761-0006 1.03 µM 0.115080913390888 0.445045990746312 no 1477 0.454190494144572 2202 12061087 SGTC_1446 4239-0190 62 µM 0.115037861730438 0.445063481538001 no 1478 0.454207555959745 2033 1340085 SGTC_331 k048-0133 24.5 µM 0.114659462798638 0.445217219971104 no 1479 0.454357522974387 2163 6813582 SGTC_2302 7771753 200 µM 0.113146298836739 0.445832080408325 no 1480 0.454957284738261 2082 2203047 SGTC_2224 6650123 117.647 µM 0.112877094177174 0.445941482972025 no 1481 0.455063998224956 2170 2908370 SGTC_1268 0828-0275 2.46 µM 0.112688865455427 0.446017980024844 no 1482 0.455138614548197 2161 745337 SGTC_2862 9027634 71.43 µM 0.112487350048919 0.446099879076971 no 1483 0.45521849964096 2134 5012562 SGTC_2197 6588183 93.1375 µM 0.112100191082569 0.446257233061614 no 1484 0.455371982959885 2194 884136 SGTC_2312 7706453 155.7 µM 0.111144396468927 0.446645735239146 no 1485 0.455750921758818 2116 976098 SGTC_218 alverine citrate 93.75 µM 0.107820008261599 0.447997396984597 no 1486 0.45706923555769 2191 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_44 0929-0055 61.211 µM 0.107496010676706 0.448129163595105 no 1487 0.45719774500232 2139 1379590 SGTC_1633 st005664 67.9 µM 0.106756180130572 0.448430066787306 no 1488 0.457491205961518 2172 2063822 SGTC_2895 9054447 58.44 µM 0.106500835705798 0.448533927130735 no 1489 0.457592496191878 2118 2697450 SGTC_1154 4088-0362 150 µM 0.105506620245757 0.448938353911335 no 1490 0.457986908557278 2221 6618304 SGTC_2798 7813637 45.45 µM 0.104608203344914 0.449303857421883 no 1491 0.458343352548112 2168 956368 SGTC_559 1550-0661 158 µM 0.104242235237829 0.449452756805277 no 1492 0.45848855882614 2139 5830875 SGTC_1249 0481-0015 10.2 µM 0.103985630021979 0.449557164571211 no 1493 0.458590376162448 2168 4227577 SGTC_1459 k035-0031 35.7 µM 0.101291152095792 0.450653705723451 no 1494 0.45965966983779 2165 3877128 YMR208W ERG12 SGTC_1919 st067113 52.3 µM 0.100463054307156 0.450990783373923 no 1495 0.459988356398342 2148 1268243 SGTC_1079 idarubicin 2.36 µM 0.0999391544992714 0.451204055342969 no 1496 0.460196315572952 2241 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3347 9188721 44.724 µM 0.0979480232721326 0.45201474380699 no 1497 0.460986783117062 2145 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1647 st011722 22.4 µM 0.0971004390827614 0.452359898369981 no 1498 0.461323316086606 2203 2854783 SGTC_1726 st035556 14.5795 µM 0.0967486835528552 0.452503151395445 no 1499 0.461462988628074 2215 5919439 SGTC_1865 st057639 52.2 µM 0.096370472010849 0.452657185573333 no 1500 0.461613171434095 2242 688818 SGTC_2749 bexarotene 57.39 µM 0.0952829302355897 0.453100148226319 no 1501 0.46204505033022 2127 82146 An retinoic acid receptor inhibitor. SGTC_1054 3429-0080 167 µM 0.0939610554590991 0.453638634727485 no 1502 0.462570046531561 2214 1162877 SGTC_2003 4023581 200 µM 0.0930113783239076 0.454025553338875 no 1503 0.462947260907511 2163 16641307 SGTC_2427 5545055 42.75 µM 0.0914095911396897 0.454678254097945 no 1504 0.463583570514955 2179 5372858 SGTC_175 3793-3120 23.7 µM 0.0888737967795468 0.455711796287682 no 1505 0.464591104134508 2174 5322297 SGTC_3288 9119690 36.221 µM 0.0879624767461466 0.456083306823825 no 1506 0.464953249858609 2156 17595618 YKL019W RAM2 SGTC_2359 9039622 200 µM 0.0879111375768696 0.456104236997161 no 1507 0.464973652186776 2191 6463596 SGTC_1509 1326-1131 80 µM 0.0871114135273292 0.456430287627998 no 1508 0.465291476596235 2247 768313 SGTC_126 0417-1624 672.48 µM 0.0868227707261963 0.456547975646758 no 1509 0.465406193773052 2253 41912 YDL195W SEC31 SGTC_2836 9010338 19.48 µM 0.0849341616937615 0.457318109770842 no 1510 0.466156866399006 2150 2994051 SGTC_2979 9012552 45.46 µM 0.0836954085414978 0.457823333890122 no 1511 0.466649303895641 2291 17100905 SGTC_2242 6630449 61.2675 µM 0.0831161588645234 0.458059603674835 no 1512 0.466879588693892 2187 691249 YDR170C SEC7 SGTC_919 tnp00227 403.569 nM 0.0829682820739012 0.458119923423553 no 1513 0.466938379935522 2188 1269246 A methoxyflavone. YNL221C POP1 SGTC_1716 st033144 30.6155 µM 0.0812454586909058 0.458822743186003 no 1514 0.467623374087271 2259 674617 SGTC_450 aminopyrene 156 nM 0.0809590487542622 0.458939595654655 no 1515 0.467737259957103 2258 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3194 9111903 49.47 µM 0.0806566560516744 0.459062972786556 no 1516 0.467857503958206 2233 17087251 SGTC_2465 5809242 33.21 µM 0.0805734856584637 0.459096907248966 no 1517 0.467890576503978 2263 2731748 SGTC_3191 9110352 49.47 µM 0.0799730579451461 0.459341897383676 no 1518 0.468129341982693 2264 17122424 SGTC_1753 st043925 64 µM 0.0781970218356784 0.46006665637503 no 1519 0.468835665498113 2247 670181 SGTC_3248 9135562 49.47 µM 0.0775273906052182 0.460339951870828 no 1520 0.469102001145389 2248 17650701 SGTC_894 0960-0238 55.9 µM 0.0773286024909594 0.460421086550403 no 1521 0.469181068764371 2261 6741907 YDL195W SEC31 SGTC_302 1094-0063 18.9 µM 0.0756083371038853 0.461123275378662 no 1522 0.469865351701928 2225 5440289 SGTC_2034 5197015 53.07 µM 0.0749185636906584 0.461404865634315 no 1523 0.470139753187748 2241 780676 SGTC_1982 st072467 71.9 µM 0.0731529823087818 0.46212572712587 no 1524 0.470842190386023 2129 3163533 SGTC_1564 D-Arginine 115 µM 0.0721707731195857 0.462526803030141 no 1525 0.471233002087412 2180 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3011 9081274 71.4286 µM 0.071982382452087 0.462603734958617 no 1526 0.47130796412157 2213 6625322 SGTC_64 000l-0018 272.079 µM 0.0715850215650738 0.462766007343134 no 1527 0.471466080275339 2208 6811119 SGTC_1026 k007-1105 30.6 µM 0.0713428784961435 0.462864895639805 no 1528 0.471562435022315 2280 7066794 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0706589863137266 0.46314420129856 no 1529 0.471834581694887 2218 4330530 SGTC_1405 3909-7894 12 µM 0.0701942944726364 0.463333994602369 no 1530 0.47201950773844 2277 7104060 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0693959536118628 0.463660079073614 no 1531 0.472337224853241 2235 4174840 SGTC_114 0364-0001 490.298 µM 0.067915204421041 0.464264959537868 no 1532 0.472926567660634 2149 4003655 SGTC_26 0302-0163 425.158 µM 0.0678636243696169 0.464286031291381 no 1533 0.472947097758086 2228 3100915 SGTC_2832 7992762 51.95 µM 0.0675716367929939 0.46440531747658 no 1534 0.473063317169249 2166 2985177 SGTC_1017 4239-0030 168 µM 0.0672161395685721 0.464550553684932 no 1535 0.47320481833211 2118 1149593 SGTC_2940 9060638 45.86 µM 0.0669935742169536 0.464641483798274 no 1536 0.473293409370659 2190 4027022 SGTC_2800 7887935 81.82 µM 0.0669514565819425 0.464658691362596 no 1537 0.473310174235949 2215 2961002 SGTC_852 0418-0143 439 µM 0.0664556162427502 0.464861276656563 no 1538 0.473507546330857 2296 5369229 SGTC_2841 9004761 38.96 µM 0.0658028409713373 0.46512799467538 no 1539 0.473767397186377 2204 2991039 SGTC_417 st075190 100 µM 0.0646940015609037 0.465581092186757 no 1540 0.474208819440051 2293 222757 SGTC_359 0081-0058 15.9 µM 0.0636660767620873 0.466001165980935 no 1541 0.474618058373436 2263 3494159 SGTC_1889 st059080 5.18 µM 0.0633312073071148 0.466138022602294 no 1542 0.474751382898281 2294 176925 Isolated from Daphnopsis sellowiana. SGTC_595 3909-8003 73.7 µM 0.0627927118837149 0.466358106795624 no 1543 0.474965784745979 2240 699517 SGTC_1189 1431-2119 7.28 µM 0.0625615615166831 0.466452581588462 no 1544 0.475057819447017 2297 3107275 SGTC_1774 st048371 48.465 µM 0.0624729978988929 0.466488779434026 no 1545 0.475093082240539 2266 4242727 SGTC_1431 4049-0260 9.09 µM 0.0623785172151129 0.466527396016653 no 1546 0.475130701208415 2275 3854841 SGTC_276 colchicine 750 µM 0.0622593051722821 0.466576121364472 no 1547 0.475178167671571 2209 2833 A microtubule depolymerizer. SGTC_2897 9048598 12.99 µM 0.0608401878444804 0.467156193195412 no 1548 0.475743242156808 2270 6467404 SGTC_2993 9054257 71.4286 µM 0.0606116250509887 0.467249626019818 no 1549 0.475834257548051 2298 6470217 YGL055W OLE1 SGTC_1244 0416-0015 52.5 µM 0.0603710457757401 0.467347972939515 no 1550 0.475930059353 2255 96201 SGTC_2179 6298986 200 µM 0.0597938164352217 0.467583947881188 no 1551 0.476159925268262 2302 738374 SGTC_2622 2-methoxyxanthone 59.94 µM 0.0594633951263948 0.467719031298039 no 1552 0.476291510160351 2279 71034 A hepatoprotective. SGTC_3095 9117207 49.47 µM 0.0589582140188026 0.467925567502505 no 1553 0.476492695282597 2293 17015229 SGTC_2514 salinomycin 42.74 µM 0.0589358462418029 0.467934712454168 no 1554 0.476501603244627 2302 23682228 A polyether potassium ionophore. SGTC_1464 k208-0027 110 µM 0.056441538058046 0.468954602694458 no 1555 0.477495033545606 2297 X1464 SGTC_3215 9129942 49.47 µM 0.0561728178473184 0.469064491177563 no 1556 0.477602067588756 2312 17682944 SGTC_1626 st003712 1.76 µM 0.0558237422611634 0.469207243119672 no 1557 0.477741110421659 2256 24207035 SGTC_3337 9144342 33.5465 µM 0.0543010326856354 0.469829990268766 no 1558 0.478347663402465 2292 17682949 SGTC_3079 9117512 49.47 µM 0.0535869687938871 0.470122048655315 no 1559 0.478632119495275 2316 7185044 SGTC_768 0384-0033 77.3 µM 0.0535860201847177 0.4701224366555 no 1560 0.478632497392622 2195 3965305 YMR134W ERG29 SGTC_1434 4073-0095 163 µM 0.0531766246105063 0.470289890303345 no 1561 0.478795590058205 2304 24133745 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0520058654129947 0.470768790761627 no 1562 0.47926200990833 2283 2724278 An inhibitor of dopamine biosynthesis. SGTC_2466 5983409 37.09 µM 0.0503812710148255 0.471433402944258 no 1563 0.479909280497842 2196 2879657 SGTC_3105 9121040 49.47 µM 0.0501702245231119 0.471519746723311 no 1564 0.479993369525327 2329 41448907 SGTC_2606 farnesol 9.78 µM 0.0496701450951788 0.471724345594249 no 1565 0.48019262392242 2303 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_363 0455-0021 3.06 µM 0.0487163145582078 0.472114609549105 no 1566 0.480572687087772 2312 4597466 SGTC_2377 9073351 62.6 µM 0.0486533434812907 0.472140375388142 no 1567 0.480597779158394 2284 7337946 YHR072W ERG7 SGTC_2326 6164455 177.58 µM 0.0480547469159824 0.472385308604318 no 1568 0.48083630561959 2282 2888790 SGTC_1264 0783-0040 158 µM 0.047891756400869 0.472452002732702 no 1569 0.480901254646371 2283 2855798 SGTC_311 1315-0136 58 µM 0.0467458109779152 0.472920934117497 no 1570 0.48135790917527 2309 6759207 SGTC_2357 9067248 200 µM 0.0466428014513903 0.472963088409346 no 1571 0.481398959254325 2256 9150235 SGTC_364 0083-0097 67.7 µM 0.0466425269827194 0.472963200729775 no 1572 0.48139906863244 2262 5207356 SGTC_283 0987-0079 11.7 µM 0.0463534740820217 0.473081490633511 no 1573 0.481514259463091 2301 411556 SGTC_3024 9090631 49.47 µM 0.045927423208097 0.473255848915112 no 1574 0.481684048337543 2333 25236383 SGTC_1714 st033236 13.627 µM 0.0444359843219892 0.473866249787845 no 1575 0.482278439312272 2311 2916566 SGTC_96 0929-0093 37.281 µM 0.0444207693026224 0.473872477154172 no 1576 0.482284503239106 2285 6991579 SGTC_2335 9018011 154.17 µM 0.0442252857936484 0.473952487308979 no 1577 0.48236241330987 2297 6458208 SGTC_1317 1273-0028 910 nM 0.0424473679644367 0.474680225584927 no 1578 0.483071034089163 2315 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_269 exalamide 29 µM 0.0420621377246749 0.47483791945272 no 1579 0.483224581580571 2233 3316 A derivative of salicylamide. SGTC_1015 4130-4525 82 µM 0.041330339559138 0.475137491619735 no 1580 0.48351627312877 2305 1363237 SGTC_905 2-aminofluorene 215 µM 0.0404588832130491 0.475494253205779 no 1581 0.483863643312685 2341 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1926 methyl fluorone black 53.6 µM 0.0400826481834538 0.475648284458123 no 1582 0.484013617713822 2334 72721 Reacts with homocysteine. SGTC_2959 9079155 11 µM 0.0394385981081418 0.475911968074012 no 1583 0.48427035349718 2292 16189457 SGTC_2406 ethylparaben 405.7 µM 0.0385678762286841 0.476268471225607 no 1584 0.48461745714183 2247 8434 A possible steroid mimic. SGTC_1182 1222-0449 220 µM 0.0383450795098691 0.476359694843483 no 1585 0.484706274472423 2296 658318 SGTC_1587 estradiol valerate 56.1 µM 0.0379964944810643 0.476502424687311 no 1586 0.484845238505219 2343 13791 A steroid. SGTC_499 genistein 192 µM 0.0377450155739643 0.476605395828004 no 1587 0.484945492156247 2341 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_113 0099-0221 2.5 µM 0.0377118639867567 0.476618970271026 no 1588 0.484958708316524 2338 89219 SGTC_2907 7721985 69.9 µM 0.037139178792888 0.476853469573184 no 1589 0.485187016702285 2319 3267881 SGTC_254 nsc-64875 3.808 µM 0.0368487280568077 0.476972404466266 no 1590 0.485302810518795 2328 56993 SGTC_2837 9008476 45.46 µM 0.0352358449456068 0.477632891123454 no 1591 0.485945839917357 2299 2992805 SGTC_652 0437-0092 114 µM 0.0352355312139285 0.477633019604756 no 1592 0.485945965000515 2337 3091274 SGTC_2971 9092186 9.93 µM 0.0342201714620565 0.478048847999829 no 1593 0.486350790729655 2307 25236400 SGTC_3196 9111891 49.47 µM 0.0340287232874216 0.478127255992605 no 1594 0.486427123044318 2357 18891510 SGTC_3104 9120930 49.47 µM 0.0339027303519429 0.478178857119968 no 1595 0.486477357967643 2249 17014836 SGTC_2306 7482397 179.52 µM 0.0338320214545784 0.478207816513623 no 1596 0.486505550563318 2334 891448 SGTC_3021 9087658 49.47 µM 0.0329219260423566 0.478580563575667 no 1597 0.486868423909119 2353 25237042 SGTC_755 1995-0008 37.3 µM 0.0328754564912183 0.478599596578684 no 1598 0.48688695254811 2348 689533 SGTC_3340 9146634 11.102 µM 0.0327219837453095 0.478662456306544 no 1599 0.486948146391605 2297 4907387 SGTC_3184 9108758 49.47 µM 0.0313746770097519 0.479214311973198 no 1600 0.487485368012674 2338 902885 SGTC_2985 9022375 71.43 µM 0.0308094274259276 0.479445849637798 no 1601 0.487710760995839 2313 4939335 SGTC_1166 k206-0078 225 µM 0.0300373907656904 0.479762102663014 no 1602 0.488018616547953 2352 5404595 SGTC_665 3914-0008 307 µM 0.0276928650843857 0.480722579060514 no 1603 0.488953557180312 2354 1069549 SGTC_1227 3909-8010 46.6 µM 0.0265823154488277 0.481177574759406 no 1604 0.489396439251655 2322 15982272 SGTC_541 4513-1321 94 µM 0.0257139741644616 0.481533354042809 no 1605 0.489742738885751 2328 747515 SGTC_3278 9139605 49.47 µM 0.0234887221055034 0.482445157173382 no 1606 0.490630217230298 2341 7958859 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0233931468868694 0.482484321471986 no 1607 0.490668335751883 2355 4620898 SGTC_2305 7443522 69.23 µM 0.0232075350781261 0.482560380962342 no 1608 0.490742364052099 2349 5415886 SGTC_965 1291-5240 308 µM 0.0230661341305374 0.482618324275166 no 1609 0.490798759771829 2366 2834598 SGTC_2245 6637752 200 µM 0.0225407103752384 0.482833635749512 no 1610 0.491008319028457 2357 681890 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.021915225428397 0.483089957455007 no 1611 0.491257789778255 2332 4213774 SGTC_3092 9117248 49.47 µM 0.0216432628923302 0.483201409007846 no 1612 0.491366261403222 2375 17141857 SGTC_697 0508-1955 564 µM 0.0197145309565191 0.483991849771239 no 1613 0.492135549502929 2373 6243113 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0193942958282381 0.484123096007279 no 1614 0.492263280411831 2363 364106 SGTC_2534 helenine 20.12 µM 0.0192156174305552 0.484196326907982 no 1615 0.4923345494976 2371 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1140 3229-1848 2.98 µM 0.0189075614188278 0.484322584155174 no 1616 0.492457423740075 2357 2849525 SGTC_1758 st042942 75.2445 µM 0.0187978961110167 0.484367531036341 no 1617 0.49250116609377 2371 669317 SGTC_2872 9044037 25.97 µM 0.0182759987595039 0.484581436018159 no 1618 0.492709337242163 2350 6465195 SGTC_1493 4348-0038 111 µM 0.0181382173694839 0.484637907876726 no 1619 0.492764294954088 2368 800424 SGTC_1453 4237-0541 195 µM 0.0180456634144297 0.484675842736478 no 1620 0.49280121259756 2368 739892 SGTC_1023 4482-3888 16 µM 0.0170032327207336 0.485103110713674 no 1621 0.49321701840365 2372 3303168 SGTC_855 0428-0020 25 µM 0.0168944090075324 0.485147716004653 no 1622 0.49326042654872 2354 6812414 SGTC_3335 9143315 29.6265 µM 0.0166477571067293 0.485248815794896 no 1623 0.493358812582788 2348 4899691 SGTC_1468 k284-1086 134 µM 0.0157586172977496 0.485613271846163 no 1624 0.493713481473075 2368 15996457 SGTC_2546 rhodinyl acetate 100 µM 0.0157008618943549 0.485636946051898 no 1625 0.493736519695118 2381 6708682 SGTC_224 benfluorex 43.875 µM 0.0155726585826345 0.485689497360354 no 1626 0.493787659164222 2380 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2455 5377712 9.75 µM 0.0152932990725687 0.485804009363093 no 1627 0.493899094212443 2343 2243908 SGTC_872 0588-0139 234 µM 0.0152581123192995 0.485818432816333 no 1628 0.493913130058324 2380 2047100 SGTC_1255 0566-0045 221 µM 0.0152517789670069 0.485821028931959 no 1629 0.493915656406355 2352 2788469 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.01491595932157 0.485958686214038 no 1630 0.49404961382081 2371 676296 Flavone; oxidizing agent. SGTC_230 MPP+ 141.667 µM 0.0123498255386145 0.487010635247331 no 1631 0.495073257673688 2356 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_303 1348-1668 34.2 µM 0.0122017509076506 0.487071339106169 no 1632 0.495132326453729 2373 5380509 SGTC_2885 9057732 51.95 µM 0.0121946707028923 0.487074241675369 no 1633 0.495135150836624 2360 6471414 SGTC_1643 st009866 20.2 µM 0.0120632729369906 0.487128109042179 no 1634 0.495187567105283 2385 3156273 YOR207C RET1 SGTC_2027 5150920 200 µM 0.0118323007008304 0.487222798177863 no 1635 0.495279705119114 2373 786715 SGTC_297 0986-0032 24 µM 0.0116342835333448 0.487303977661837 no 1636 0.495358697101734 2382 2847425 SGTC_1164 k060-0068 93.7 µM 0.0112786846615639 0.487449760950915 no 1637 0.495500551216248 2387 5963676 SGTC_998 3996-0085 177 µM 0.0103786509050086 0.487818751239609 no 1638 0.495859591672242 2367 715391 SGTC_129 0088-0017 176.636 µM 0.0102779267799768 0.487860046149785 no 1639 0.495899772641176 2379 182446 SGTC_1409 3909-8004 61.9 µM 0.00934608590044612 0.488242088696764 no 1640 0.496271505458372 2376 2119279 SGTC_3203 9113543 49.47 µM 0.00923854436031326 0.488286180019763 no 1641 0.49631440647338 2372 17018012 SGTC_1552 6-methylflavone 10.6 µM 0.00715802444949756 0.489139207005391 no 1642 0.497144385788636 2392 689013 SGTC_1659 st012954 42.1 µM 0.00688020589791797 0.48925311830263 no 1643 0.497255216624545 2380 24207262 SGTC_3127 9126946 49.47 µM 0.00593546374122471 0.489640488443282 no 1644 0.497632106463219 2375 27243249 SGTC_3170 9103054 49.47 µM 0.00587523823178306 0.489665182885639 no 1645 0.497656132546354 2393 16432970 SGTC_1772 st048439 82.2 µM 0.00536362223536866 0.489874963882095 no 1646 0.497860234573835 2386 2927068 YDL195W SEC31 SGTC_1614 st002383 48.6 µM 0.00518436005036275 0.489948468503911 no 1647 0.497931748844024 2393 1947235 SGTC_325 2810-4341 181 µM 0.00476644367582503 0.49011983215163 no 1648 0.498098471290698 2395 774970 SGTC_2938 9059746 27.26 µM 0.00417439907811537 0.490362598957608 no 1649 0.498334660549064 2393 6471769 SGTC_1261 0712-0010 12.7 µM 0.00304376390044941 0.490826223690793 no 1650 0.498785715763507 2393 2840123 SGTC_1047 2043-3044 82 µM 0.00225132914573214 0.491151174438706 no 1651 0.499101850375377 2399 669592 SGTC_848 0368-0089 85.6 µM 0 0.492074399859956 no 1652 0.5 2404 762535 SGTC_1393 3470-5649 58.2 µM -0.000488690199860072 0.492274807795269 no 1653 0.499805040825018 2408 4108395 SGTC_1344 1488-0097 29.1 µM -0.00109238589308529 0.492522381248779 no 1654 0.499564201167408 2406 747966 SGTC_2251 lansoprazole 556 µM -0.00110716806954996 0.492528443403213 no 1655 0.499558303935786 2408 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.00295825149023709 0.493287583873397 no 1656 0.498819830125811 2414 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2756 carbadox 75.1 µM -0.0029934518915871 0.493302020014451 no 1657 0.498805787259606 2416 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2351 9026858 72.31 µM -0.00338080276923848 0.493460878207563 no 1658 0.498651257402969 2415 1409300 SGTC_2607 solasodine 47.35 µM -0.00501343229977939 0.494130454274065 no 1659 0.497999938264118 2419 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_856 0433-0016 11.3 µM -0.00524613102730874 0.494225890357834 no 1660 0.497907106124751 2419 3911780 SGTC_1652 st011932 78 µM -0.0075695006190098 0.495178784710805 no 1661 0.496980234998997 2421 1551076 SGTC_884 0851-0618 334 µM -0.00773259295402933 0.495245675623648 no 1662 0.49691517247538 2421 9642473 SGTC_2998 9066762 71.4286 µM -0.00814247974044906 0.495413787735515 no 1663 0.496751656458446 2429 4945196 SGTC_1935 st074532 41.6 µM -0.00953231012969229 0.495983822540556 no 1664 0.496197216049408 2473 2829742 SGTC_1527 coumarin 137 µM -0.0107506917084731 0.496483544910057 no 1665 0.495711177149234 2452 323 A hepatotoxic, DNA x-linker. SGTC_1415 3966-0071 78.1 µM -0.0111320712615786 0.496639969895292 no 1666 0.495559037828404 2432 2893185 SGTC_2064 5220758 200 µM -0.0130365252710148 0.497421099752821 no 1667 0.494799326190232 2446 788518 SGTC_2727 riluzole 51.77 µM -0.0135548598561377 0.497633701431868 no 1668 0.494592558887645 2425 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2718 lomofungin 53.02 µM -0.0138944061042568 0.497772971114658 no 1669 0.494457112291107 2428 5351222 A RNA synthesis inhibitor. SGTC_2571 chrysanthemic acid 100 µM -0.0146760450593189 0.498093572360228 no 1670 0.494145315287327 2451 2743 An insecticide. SGTC_136 0097-0015 404.482 µM -0.0147863353848941 0.498138809738345 no 1671 0.494101320587217 2421 4861337 SGTC_1616 st002734 56.1 µM -0.0157285633438653 0.498525280838584 no 1672 0.493725469780165 2448 4026101 SGTC_2252 omeprazole 400 µM -0.0168374720852326 0.498980120691187 no 1673 0.493283137863879 2494 4594 A proton pump inhibitor. SGTC_1847 st056231 15 µM -0.0175676694947119 0.499279625702911 no 1674 0.492991874350435 2436 5393180 SGTC_460 trequinsin 123 µM -0.0178824004683616 0.499408719015722 no 1675 0.492866334581007 2430 5537 A vasodilator. SGTC_2273 7815444 169.05 µM -0.0183338136541977 0.499593875423661 no 1676 0.492686276300069 2446 2824616 SGTC_1724 st037281 8.293 µM -0.0183493975504254 0.499600267481196 no 1677 0.49268006027064 2443 574124 YDL195W SEC31 SGTC_2540 epiandrosterone 100 µM -0.018878829331673 0.499817424932718 no 1678 0.492468884138851 2442 441302 A steroid. SGTC_2849 9019321 12.99 µM -0.0197690683618631 0.499817424932718 no 1679 0.492113796465489 2472 16489627 SGTC_1012 4112-3522 18 µM -0.0201163458089461 0.499674981858077 no 1680 0.491975280356982 2445 3112398 SGTC_2775 cyproheptadine 69.59 µM -0.0207175658289595 0.499428379058928 no 1681 0.491735478260997 2436 2913 A selective serotonin reuptake inhibitor. SGTC_371 0195-0006 7.36 µM -0.0209153008004711 0.499347274022644 no 1682 0.491656610510167 2422 3928593 SGTC_920 mycophenolic acid 780.421 nM -0.0209635426171182 0.499327486660422 no 1683 0.491637369028592 2457 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1629 st005085 44.9 µM -0.0221819515072566 0.498827732153633 no 1684 0.491151407329965 2445 24207091 SGTC_2420 aureobasidin a 50 nM -0.0224996661242706 0.498697415489599 no 1685 0.491024689163878 2468 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2442 5158906 48.48 µM -0.0225599980846802 0.498672669209321 no 1686 0.491000626301864 2471 1893835 SGTC_1834 st055981 52.8 µM -0.0227571404080055 0.498591807639833 no 1687 0.490921998080839 2469 471719 YDL150W RPC53 SGTC_1411 3909-8223 150 µM -0.0229174235250059 0.498526064597911 no 1688 0.490858071041175 2448 X1411 SGTC_764 1951-2361 146 µM -0.0231034718157079 0.498449753550689 no 1689 0.490783868159023 2442 5438930 SGTC_1356 1502-0781 85.8 µM -0.0231814315867196 0.498417776967422 no 1690 0.490752775037638 2444 567702 SGTC_2322 7413319 38.22 µM -0.0240791428458675 0.498049565551348 no 1691 0.490394740048409 2481 1840400 SGTC_781 4335-2806 94.4 µM -0.0241117610186649 0.498036186686938 no 1692 0.49038173105717 2519 845254 SGTC_1676 st018489 23.4 µM -0.0247731921141065 0.497764890658954 no 1693 0.490117937044047 2487 3696235 SGTC_2952 9073731 13.78 µM -0.0259699399721803 0.497274029028559 no 1694 0.489640657394039 2451 16457353 SGTC_425 3825-7017 13.1 µM -0.0267712717765582 0.496945354673837 no 1695 0.489321083401802 2602 3397440 SGTC_1421 4029-0249 71.4 µM -0.0272633648979796 0.496743518709986 no 1696 0.48912483828796 2467 2894095 SGTC_522 1273-0010 11.6 µM -0.0273458989002375 0.496709666803318 no 1697 0.489091924256596 2611 5705015 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.028356796281443 0.496295042065711 no 1698 0.488688790952331 2445 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1081 sertraline 6 µM -0.0291465763953204 0.495971112469687 no 1699 0.488373844484513 2449 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0292672721901524 0.495921609122155 no 1700 0.488325714361862 2446 97141 SGTC_885 0865-0106 16.8 µM -0.0303206043126927 0.495489587986577 no 1701 0.487905682130507 2465 2793380 SGTC_2644 guaiazulene 100 µM -0.0304863261180944 0.495421618134147 no 1702 0.487839599245224 2472 3515 A coloring agent. SGTC_1476 4112-3294 3.34 µM -0.0310860504194983 0.49517564576077 no 1703 0.487600457223385 2526 704369 SGTC_2065 5221596 34.26 µM -0.0324887354664621 0.49460035245252 no 1704 0.487041149542251 2496 788581 SGTC_737 1950-0117 57.9 µM -0.0327975144340545 0.494473712179749 no 1705 0.486918030171122 2453 5393513 SGTC_49 0717-0965 32.132 µM -0.0342840927305686 0.49386402621138 no 1706 0.486325304787581 2672 5889349 YGL099W LSG1 SGTC_1224 0823-0416 294 µM -0.03437389951005 0.493827194466829 no 1707 0.486289498171099 2498 3598164 SGTC_827 3253-0474 693 µM -0.034740570292458 0.493676815226737 no 1708 0.48614330501201 2474 5402065 SGTC_2974 9094440 9.66 µM -0.0354304108324246 0.493393899865417 no 1709 0.485868267795699 2648 25236134 SGTC_214 4373-3496 70 µM -0.0366837695946719 0.492879884680219 no 1710 0.485368574959978 2495 3779166 SGTC_1032 k061-1018 98.7 µM -0.0376752226365398 0.492473288029307 no 1711 0.484973315719526 2619 4005393 SGTC_613 3914-0030 117 µM -0.0382388414517999 0.492242150412786 no 1712 0.484748626264499 2451 1145395 SGTC_1400 3771-8998 51.5 µM -0.0390012149322103 0.491929508534485 no 1713 0.484444709988156 2495 670767 SGTC_1145 3546-0597 10.2 µM -0.0392350171103061 0.491833629541499 no 1714 0.484351507751852 2519 875334 SGTC_2421 5690543 90.72 µM -0.0399977290005199 0.491520855405359 no 1715 0.484047468420413 2502 3397993 SGTC_1996 st072960 66.8 µM -0.0406040850443999 0.491272203640166 no 1716 0.483805763724878 2458 1719405 SGTC_280 3448-3607 3.04 µM -0.0407142450764364 0.491227030069843 no 1717 0.48376185254179 2471 626179 SGTC_3338 9144300 39.5675 µM -0.0416435355336326 0.49084595839239 no 1718 0.48339143349411 2508 4901274 SGTC_2294 7971431 200 µM -0.041892192978078 0.490743993494995 no 1719 0.483292320018586 2526 5741572 SGTC_4 0960-0234 25.671 µM -0.0424553510646564 0.490513066172425 no 1720 0.483067852161354 2480 6821112 SGTC_3025 9087895 49.47 µM -0.0440632847327317 0.489853738318666 no 1721 0.482426979441221 2494 17173641 SGTC_643 k048-0106 28.4 µM -0.0468803564967977 0.488698675332376 no 1722 0.481304292061398 2565 6763920 SGTC_3173 9105693 49.47 µM -0.0472653451283944 0.488540828451879 no 1723 0.481150873890001 2538 17096658 SGTC_1829 berberine 14.4 µM -0.0476438612321726 0.488385637083455 no 1724 0.481000037745867 2605 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1473 k844-0725 134 µM -0.0477033416918049 0.488361250291077 no 1725 0.480976335425963 2478 54682906 SGTC_1559 coumarin 343 70.1 µM -0.047739963873212 0.48834623533906 no 1726 0.480961741916175 2534 108770 A hepatotoxic, DNA x-linker. SGTC_735 3076-0345 636 µM -0.0482564505053235 0.488134479596613 no 1727 0.480755930776968 2517 2888990 SGTC_110 0850-0284 111.64 µM -0.0505649679630644 0.487188046050438 no 1728 0.479836089306502 2482 3906265 SGTC_2596 sinensetin 100 µM -0.0524338005096284 0.486421924753427 no 1729 0.479091521118731 2543 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2483 5729050 27.16 µM -0.0539711440157108 0.485791733657053 no 1730 0.47847907723066 2520 2865180 SGTC_2025 5147754 141 µM -0.0545511678238801 0.485553978206883 no 1731 0.478248021609088 2537 315777 YLR208W SEC13 SGTC_2825 7998094 58.44 µM -0.0552944867227773 0.485249294578746 no 1732 0.477951927203155 2551 2987815 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0553550721389165 0.485224461221104 no 1733 0.477927794081068 2572 6708760 SGTC_2744 captopril 92.04 µM -0.0556874035695571 0.485088242905048 no 1734 0.477795417213193 2525 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2930 9013230 14.89 µM -0.0556983902819573 0.485083739624653 no 1735 0.477791040941298 2531 2995857 SGTC_700 3453-2283 142 µM -0.056444569948023 0.484777896812466 no 1736 0.477493825921672 2555 565664 SGTC_1078 idebenone 36.1 µM -0.0565957853667601 0.484715917987401 no 1737 0.477433595977814 2558 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0569176150101003 0.484584010559114 no 1738 0.477305411155271 2506 688662 SGTC_1854 st056233 32.9 µM -0.0571974765887122 0.484469305836618 no 1739 0.477193944131012 2496 5393174 SGTC_2457 5731572 11.68 µM -0.057600325047995 0.484304195681881 no 1740 0.477033495376859 2505 2865357 SGTC_650 1328-0195 38 µM -0.0577097701819149 0.4842593393202 no 1741 0.476989905594312 2498 2780821 SGTC_2167 5876490 200 µM -0.059819323833707 0.483394773083056 no 1742 0.476149767471134 2720 686534 SGTC_3346 9158254 43.5805 µM -0.0601371839878705 0.483264509939394 no 1743 0.47602318750062 2569 17639500 SGTC_3192 9110362 49.47 µM -0.0601494772491555 0.483259472039979 no 1744 0.476018292060882 2501 16649480 SGTC_2638 epoxomicin 18 µM -0.0617999522294901 0.48258311574783 no 1745 0.475361070765962 2582 9915668 A protesome inhibitor. SGTC_1789 tunicamycin 25 nM -0.0620408951709207 0.482484382696333 no 1746 0.475265132536347 2590 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_695 3505-6186 243 µM -0.0620643205935076 0.48247478353705 no 1747 0.475255805119869 2573 1819379 SGTC_1520 flindersine 88 µM -0.0626453799614282 0.482236683032813 no 1748 0.475024446187808 2714 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1981 st071826 47 µM -0.0636499162386014 0.481825069528955 no 1749 0.474624492439798 2580 11838600 SGTC_3316 9136639 10.545 µM -0.0639375434800269 0.481707216451224 no 1750 0.47450997902401 2609 4903665 SGTC_1943 st076331 65.2 µM -0.0641580419152848 0.481616869973963 no 1751 0.474422193114535 2516 24208415 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0647525306093717 0.481373290380882 no 1752 0.474185518583959 2538 115019 SGTC_2456 5770359 74.46 µM -0.0652878508799084 0.481153959787594 no 1753 0.47397240765005 2522 3118787 SGTC_2254 7938975 95.19 µM -0.0662995331979601 0.480739470504654 no 1754 0.473569677431469 2599 2969277 SGTC_3292 9120825 59.784 µM -0.0665058234178823 0.480654955323459 no 1755 0.473487560779686 2523 24824900 SGTC_1849 st056239 19.2 µM -0.0683292813715476 0.479907939832567 no 1756 0.472761757714726 2543 5393181 SGTC_1043 0916-0009 19.3 µM -0.0683940532581968 0.479881406034779 no 1757 0.472735977779909 2508 3101130 SGTC_2126 5251174 33.877 µM -0.0684240715794456 0.479869109062288 no 1758 0.472724030191271 2547 790722 SGTC_1234 0326-0494 15.5 µM -0.0684822418530618 0.479845279727827 no 1759 0.472700877917125 2620 1547813 SGTC_1618 st003135 44.5 µM -0.0704005465078642 0.479059490983948 no 1760 0.471937428139573 2520 1270615 SGTC_711 k292-0785 179 µM -0.0704071346364791 0.479056792449259 no 1761 0.471934806362261 2532 4146315 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0711885518874206 0.478736726374153 no 1762 0.471623846285462 2698 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1645 Cervolide 78 µM -0.0712040770072469 0.478730367471605 no 1763 0.471617668336364 2589 23173 A fragrance. SGTC_3009 9080819 71.4286 µM -0.0721376352533935 0.478348003240289 no 1764 0.471246187814646 2594 17027216 SGTC_2505 galangin 7.89 µM -0.0737988333044887 0.477667663794592 no 1765 0.470585227691882 2533 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_635 k038-0028 24.7 µM -0.0739162534857452 0.477619577096731 no 1766 0.470538511408141 2566 4035102 SGTC_805 3852-0218 479 µM -0.0749252085637869 0.477206396567866 no 1767 0.47013710969667 2558 6615355 SGTC_2904 7225135 42.03 µM -0.0754884872170079 0.476975737094031 no 1768 0.469913028635209 2594 4446116 SGTC_2729 fluphenazine 10.66 µM -0.0779647876391175 0.475961798382476 no 1769 0.468928031547583 2555 3372 An atypical antipsychotic. SGTC_2763 lisinopril 49.32 µM -0.0781285396257263 0.4758947543882 no 1770 0.468862902618398 2529 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0781699680676803 0.475877792697644 no 1771 0.468846425453736 2518 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_798 1287-0182 476 µM -0.0797898015757236 0.475214632772969 no 1772 0.468202217813297 2547 1649755 SGTC_1898 st060199 18.6 µM -0.0799204114855509 0.475161164035608 no 1773 0.468150277868664 2555 688866 SGTC_2178 5812956 200 µM -0.0800327848302323 0.475115161292732 no 1774 0.468105590534898 2517 5403383 SGTC_3202 9113761 49.47 µM -0.0800494557373058 0.475108336682501 no 1775 0.468098961075348 2703 4798415 SGTC_2772 vinpocetine 57.06 µM -0.0804507424835404 0.474944063148584 no 1776 0.467939385494584 2616 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_416 estradiol valerate 100 µM -0.0815355729924522 0.474499990786452 no 1777 0.467508017943654 2593 13791 A steroid. SGTC_722 3534-0461 190 µM -0.0816543050748572 0.474451390051055 no 1778 0.467460808113084 2592 658262 SGTC_1778 st046819 58.9 µM -0.0825360503657363 0.474090476214462 no 1779 0.467110226034779 2556 671715 SGTC_2207 7258803 200 µM -0.0827086195750304 0.474019843084483 no 1780 0.467041615464419 2559 3666799 SGTC_2444 5485484 36.41 µM -0.082839661958437 0.473966207562755 no 1781 0.466989515904846 2633 6790631 SGTC_1487 3970-0795 2.82 µM -0.0830724022611001 0.47387094834428 no 1782 0.466896984891843 2615 3765103 SGTC_2536 dehydroabietamide 32.04 µM -0.0850550495119758 0.473059523767831 no 1783 0.466108813021807 2623 3983547 SGTC_1696 st025591 34.7925 µM -0.0851756288347167 0.473010178658998 no 1784 0.466060882764953 2570 2787147 SGTC_2134 5324836 1.464 µM -0.085388684002546 0.472922990341249 no 1785 0.465976194581793 2597 699272 SGTC_2745 rifampicin 24.3 µM -0.0860100391212348 0.472668721334709 no 1786 0.465729218368688 2628 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_882 0843-0131 351 µM -0.086164289608143 0.472605601152385 no 1787 0.465667908931297 2551 5425421 SGTC_2183 6420625 130.508 µM -0.0874456568225594 0.472081285094366 no 1788 0.465158639724454 2550 2897619 SGTC_753 1322-0200 289 µM -0.0875344737677543 0.472044944327933 no 1789 0.465123342241155 2671 5403907 SGTC_2051 5263410 176 µM -0.0880668281952855 0.471827128530659 no 1790 0.46491178058751 2546 227584 SGTC_1656 st012921 11 µM -0.088487492623464 0.47165501727901 no 1791 0.464744612392038 2616 6732821 SGTC_1500 4488-1866 171 µM -0.0885123421289686 0.471644850481705 no 1792 0.464734737620232 2681 2900003 SGTC_66 0109-0187 42.4 µM -0.0886573177609792 0.471585536275005 no 1793 0.464677127197412 2540 759417 SGTC_3154 9100113 49.47 µM -0.0889599540011046 0.471461720061286 no 1794 0.464556867983049 2567 25237525 SGTC_634 1611-4317 11.2 µM -0.089110858043884 0.471399982393853 no 1795 0.464496904127654 2552 2843522 SGTC_135 0933-0004 26.348 µM -0.0891480015197212 0.47138478640825 no 1796 0.464482144765879 2636 21230617 YGL099W LSG1 SGTC_1777 st045864 34.765 µM -0.0899101749038172 0.471072978407493 no 1797 0.464179297749382 2573 4691462 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0902892470767598 0.470917905145284 no 1798 0.464028682420021 2577 688664 SGTC_3144 9087057 49.47 µM -0.0904402627812048 0.470856127904731 no 1799 0.4639686813494 2535 17249618 SGTC_2947 9072639 7.68 µM -0.0905067388597185 0.470828934208888 no 1800 0.463942269548851 2634 16488146 SGTC_372 0155-0182 15.9 µM -0.0907296095774487 0.470737764383283 no 1801 0.463853721307791 2567 771486 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.09126604378254 0.4705183312972 no 1802 0.46364059924423 2546 5355888 SGTC_1523 st012844 44.7 µM -0.0952707791501285 0.468880446783661 no 1803 0.462049875959425 2694 4274103 SGTC_89 0302-0250 142.109 µM -0.0955120487491732 0.468781787205116 no 1804 0.461954060247418 2553 4203518 YLR208W SEC13 SGTC_973 1325-0077 65.9 µM -0.0959747453191921 0.468592587432412 no 1805 0.461770315134416 2656 2835149 SGTC_90 0870-0863 4.608 µM -0.0963881904554739 0.468423532905214 no 1806 0.461606135551466 2573 1738164 SGTC_1784 st039334 36.3 µM -0.0968804109856824 0.468222275153978 no 1807 0.461410682694217 2804 3496984 SGTC_3031 9088762 49.47 µM -0.0974858151049616 0.467974750356682 no 1808 0.461170299240123 2572 205253 SGTC_2742 clothiapine 36.27 µM -0.0980830761094437 0.467730567075426 no 1809 0.460933163015259 2562 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_759 3486-0358 89.3 µM -0.0995503848590747 0.467130726540269 no 1810 0.460350642604865 2575 875103 SGTC_809 3998-0021 90 µM -0.100260160228079 0.466840594787633 no 1811 0.46006889280219 2569 715485 SGTC_2234 tolnaftate 200 µM -0.10038950421846 0.46678772530746 no 1812 0.460017551046224 2590 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3139 9095020 49.47 µM -0.100931007675139 0.466566391622736 no 1813 0.459802614110888 2551 25236292 SGTC_2733 amorolfine 100 µM -0.101612819183298 0.466287723251305 no 1814 0.459532001941649 2616 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2066 5222451 176 µM -0.10191982584952 0.466162249607983 no 1815 0.459410156577701 2588 2281147 SGTC_1885 st057546 99.9 µM -0.102740493353437 0.465826859294304 no 1816 0.45908446731447 2746 702008 SGTC_922 1866-0035 480 µM -0.104082637345088 0.46527840443164 no 1817 0.45855188470287 2600 3156169 SGTC_2865 9030313 51.95 µM -0.104739307592347 0.465010086105797 no 1818 0.458291335268834 2593 42562754 SGTC_581 0958-0271 211 µM -0.104926578265676 0.464933569402281 no 1819 0.458217034484078 2572 4591145 SGTC_1657 st012939 43.4 µM -0.105690059500095 0.464621632954007 no 1820 0.457914133772346 2674 24207257 SGTC_1725 st036284 20.55 µM -0.106087838037596 0.464459120700202 no 1821 0.457756330264554 2791 707914 SGTC_2828 7998861 71.43 µM -0.106838656902427 0.464152390148149 no 1822 0.457458489599423 2620 2988188 SGTC_143 4032-1194 15.74 µM -0.10718492598178 0.464010936690509 no 1823 0.457321136928439 2563 1806963 SGTC_717 1532-0246 73.2 µM -0.107241066664678 0.463988003238037 no 1824 0.457298868389143 2649 9561992 SGTC_2431 5490079 200 µM -0.107366849007129 0.463936621622569 no 1825 0.457248976553809 2640 5722345 SGTC_2675 theaflavin digallate 100 µM -0.107403050411547 0.463921833595976 no 1826 0.4572346173141 2617 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_597 k018-0003 82.8 µM -0.108060544661885 0.463653260376584 no 1827 0.456973832813474 2700 6786234 SGTC_75 0159-0059 199.013 µM -0.109390637796001 0.46310999477108 no 1828 0.456446329571489 2787 5377270 SGTC_2117 5521686 200 µM -0.109399543424389 0.463106357571098 no 1829 0.456442797935192 2602 803312 SGTC_1004 4084-0029 199 µM -0.109933869167164 0.462888136111859 no 1830 0.456230910806727 2674 716894 YLR208W SEC13 SGTC_2809 7964133 12.99 µM -0.111018367944752 0.462445255481551 no 1831 0.455800890627896 2647 1253665 SGTC_1085 doxorubicin 7.67 µM -0.111714998447929 0.46216079452214 no 1832 0.455524693367119 2629 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_139 0099-0334 718.624 µM -0.113299365959296 0.461513908774794 no 1833 0.45489660994795 2605 97690 SGTC_1170 0310-0127 64.8 µM -0.114234879581966 0.461131993052161 no 1834 0.454525801484151 2689 774975 SGTC_2677 mitomycin C 100 µM -0.114267263131103 0.461118773375099 no 1835 0.454512966361577 2619 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2983 9022671 12.99 µM -0.115078168939224 0.460787757833897 no 1836 0.454191581796429 2828 6405161 SGTC_2640 pentamidine 10.38 µM -0.117872902541729 0.459647144108671 no 1837 0.453084182089831 2692 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2340 7987427 183.45 µM -0.118675874402915 0.459319488455507 no 1838 0.452766075442333 2702 2239331 SGTC_1653 st012112 65 µM -0.118831879200217 0.459255833316641 no 1839 0.452704275836714 2738 720429 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.119297824794076 0.459065718263743 no 1840 0.45251970337841 2591 2346 DNA damaging agent; causes G2/M arrest. SGTC_2171 5739187 198.077 µM -0.120267109626914 0.458670260850445 no 1841 0.452135778838617 2598 2262761 SGTC_1347 1493-0251 600 nM -0.120472991228909 0.458586268703583 no 1842 0.452054236836859 2709 3986378 SGTC_2156 5649887 115 µM -0.120594763075497 0.45853659112378 no 1843 0.452006008514833 2736 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_588 3970-1144 52.9 µM -0.121895438891403 0.45800601291539 no 1844 0.451490913964422 2757 1888707 SGTC_1279 0874-0590 65.2 µM -0.122456948104849 0.457776982325811 no 1845 0.451268569876976 2690 3523074 SGTC_532 1548-0774 215 µM -0.124466545200191 0.456957415355014 no 1846 0.450472943714394 2831 5932993 SGTC_314 1671-0008 2.74 µM -0.125603742796575 0.456493716900074 no 1847 0.450022800049882 2619 3913060 SGTC_3295 9122362 53.5725 µM -0.126709261832027 0.456042992329885 no 1848 0.449585257523534 2705 4730473 SGTC_1786 berberine 21.6 µM -0.12802000873346 0.455508668860421 no 1849 0.449066569325206 2621 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1857 st056007 79.3 µM -0.128246209242661 0.455416466769778 no 1850 0.448977066138287 2707 619834 SGTC_946 3434-1334 87.4 µM -0.128639207508696 0.455256281589148 no 1851 0.448821570466738 2751 4047976 SGTC_758 0868-0029 16 µM -0.129372101400107 0.454957575192906 no 1852 0.448531610998816 2756 762687 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.129824810006988 0.454773076944302 no 1853 0.448352516741375 2715 551469 SGTC_164 4100-3994 89.624 µM -0.130484629578104 0.454504189543448 no 1854 0.448091506996329 2630 4615967 SGTC_3264 9137442 49.47 µM -0.13056574309007 0.454471135880642 no 1855 0.448059421868658 2824 17015726 SGTC_1315 1237-0019 3.69 µM -0.130810620878316 0.4543713503772 no 1856 0.44796256047488 2704 825140 SGTC_2485 5633444 17.78 µM -0.131013589162951 0.454288644803087 no 1857 0.447882278733983 2716 5724239 SGTC_3137 9097352 49.47 µM -0.131427025941994 0.45412018360118 no 1858 0.447718755238097 2898 44120435 SGTC_664 1222-0054 14.9 µM -0.131551471923807 0.454069477778241 no 1859 0.447669535806554 2673 6813991 SGTC_310 1273-0058 1.06 µM -0.132569531272615 0.453654695164887 no 1860 0.447266915105156 2680 2734232 SGTC_2225 6654152 15.4 µM -0.13363864519587 0.453219166073679 no 1861 0.446844161909848 2639 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_903 1134-0042 114 µM -0.13398354661544 0.453078674221009 no 1862 0.446707792508076 2650 701009 SGTC_1463 k081-0032 34.1 µM -0.134375944021523 0.452918842536102 no 1863 0.446552651493351 2693 977755 SGTC_549 1661-1316 519 µM -0.134578729126481 0.452836246901948 no 1864 0.446472480144071 2696 2857282 SGTC_1176 0848-0131 83.3 µM -0.13556812329691 0.452433289836099 no 1865 0.446081353338525 2742 6769040 SGTC_1903 st060211 78.3 µM -0.136295768762183 0.452136968124215 no 1866 0.445793734355251 2785 688960 SGTC_628 1636-0253 16 µM -0.137020432190522 0.451841887293863 no 1867 0.4455073224401 2738 4456143 SGTC_1119 parthenolide 318.541 nM -0.137192883724282 0.451771669445939 no 1868 0.445439167845075 2833 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3212 9128307 49.47 µM -0.137316913444589 0.451721168652983 no 1869 0.445390151038563 2673 27243542 SGTC_718 1130-0073 349 µM -0.13950857889422 0.450828924706692 no 1870 0.444524138627957 2773 6740020 SGTC_826 1683-5028 118 µM -0.140257500517247 0.450524089644325 no 1871 0.444228271001207 2727 722377 SGTC_3014 9081533 49.47 µM -0.142684355980709 0.449536483242387 no 1872 0.443269736204702 2756 21367265 SGTC_1816 st051957 91.6 µM -0.143010866146307 0.449403633974033 no 1873 0.443140799731696 2658 674121 SGTC_251 melphalan 456.522 µM -0.143404203727519 0.449243601742436 no 1874 0.442985481597853 2729 460612 A DNA alkylator. SGTC_84 0443-0269 128.823 µM -0.143762420791164 0.449097865729259 no 1875 0.442844039206849 2663 6150058 SGTC_2084 5306078 60.6385 µM -0.144910792741668 0.448630711735282 no 1876 0.442390652504879 2741 679340 SGTC_1297 1068-0111 14.1 µM -0.145631589018271 0.448337530478636 no 1877 0.442106114699936 2655 767057 SGTC_1496 4469-0713 57.4 µM -0.145632709800023 0.448337074626674 no 1878 0.442105672289155 2667 746691 SGTC_957 1187-1561 14.1 µM -0.146087663022788 0.448152038604568 no 1879 0.44192609270635 2650 1538454 SGTC_2196 6573537 42.6665 µM -0.146527307325273 0.447973239657365 no 1880 0.441752567214559 2743 2903087 SGTC_1101 ebselen 5.29 µM -0.146962132625854 0.44779641094651 no 1881 0.441580954754544 2690 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2487 5918373 44.05 µM -0.148152834434078 0.447312246082823 no 1882 0.441111076809016 2650 2876279 SGTC_1571 st070080 73.4 µM -0.148168123026156 0.447306029922688 no 1883 0.441105044121287 2797 4315245 SGTC_195 4234-0266 16.654 µM -0.148408778483548 0.447208183975587 no 1884 0.441010086281125 2709 2303354 SGTC_31 0508-1974 57.237 µM -0.148562808547705 0.447145559957295 no 1885 0.440949310871783 2702 6810525 SGTC_615 k087-0205 167 µM -0.148634386307673 0.447116459028783 no 1886 0.440921069016548 2685 9642773 SGTC_3325 9138760 55.175 µM -0.148882946502412 0.447015405655155 no 1887 0.440822998974083 2699 43844959 SGTC_3072 9116419 49.47 µM -0.149589041911744 0.446728357870029 no 1888 0.440544427093652 2752 17170162 SGTC_742 0kpi-0133 140 µM -0.150677316905038 0.446285997965454 no 1889 0.44011513370301 2819 2728852 SGTC_463 ikarugamyin 104 µM -0.150817658167801 0.446228957175673 no 1890 0.440059778198068 2661 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2905 7799065 20.05 µM -0.151225467540715 0.446063212037847 no 1891 0.439898930563818 2770 1296806 SGTC_261 5-fluorouridine 15.376 µM -0.15147772604001 0.445960691842606 no 1892 0.439799440063653 2856 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1650 st011916 45.8 µM -0.152932876817947 0.445369375799545 no 1893 0.439225604457192 2718 242528 SGTC_1472 k841-0093 193 µM -0.152941746997981 0.445365771678553 no 1894 0.439222106910949 2781 X1472 SGTC_945 3381-0768 11.3 µM -0.153264093044242 0.445234799482798 no 1895 0.439095007841492 2720 1126236 YIL048W NEO1 SGTC_2646 retinol 96.75 µM -0.153747440658029 0.44503842205883 no 1896 0.438904438611775 2761 445354 A vitamin A analog and teratogen. SGTC_1036 k216-0215 33.5 µM -0.154889292204257 0.444574557282395 no 1897 0.438454297677111 2664 622330 SGTC_1735 st034310 56.75 µM -0.155313688550205 0.444402170194115 no 1898 0.438287012329925 2894 871153 SGTC_1318 1280-3875 124 µM -0.155451356350254 0.444346252669472 no 1899 0.438232749843039 2745 373245 SGTC_2334 9017922 200 µM -0.157224616141386 0.44362609434847 no 1900 0.437533914343525 2837 3163164 SGTC_1378 2093-0007 380 nM -0.157261829243207 0.443610983306279 no 1901 0.437519250869375 2778 3618014 SGTC_1208 2323-2347 50.3 µM -0.157420624327112 0.443546502658457 no 1902 0.437456680118812 2780 5412760 SGTC_2954 9074818 52.69 µM -0.158433622755746 0.44313519775256 no 1903 0.437057560611157 2806 16648742 SGTC_1713 st033146 12.748 µM -0.15951188217306 0.442697462432781 no 1904 0.436632798777292 2786 674619 SGTC_87 0100-0052 35.5 µM -0.160296949915181 0.442378796568168 no 1905 0.436323580712163 2710 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.160427520373684 0.442325800486959 no 1906 0.436272156123546 2933 6710655 SGTC_551 k048-0028 34.9 µM -0.160544457392746 0.442278338837206 no 1907 0.436226101918139 2829 6836383 SGTC_1425 4048-4433 7.33 µM -0.161026302411985 0.442082779409041 no 1908 0.436036342317039 2725 23734946 SGTC_174 3553-0389 74.3 µM -0.161307759027684 0.441968555234097 no 1909 0.435925506234599 2816 738071 SGTC_790 1575-0012 79.1 µM -0.162236948592163 0.441591494441707 no 1910 0.43555963221891 2837 378741 YLR208W SEC13 SGTC_2013 4024628 200 µM -0.162325025947884 0.441555755802363 no 1911 0.43552495408375 2838 5230760 SGTC_3032 9089427 49.47 µM -0.165242917018273 0.440372050744555 no 1912 0.43437639332313 2799 17173707 SGTC_3223 9129970 49.47 µM -0.1656323056205 0.440214126967078 no 1913 0.434223161113406 2714 17248386 SGTC_2265 7929201 200 µM -0.165859766383791 0.440121880429968 no 1914 0.434133655320809 2671 1265108 SGTC_1325 1431-0015 227 µM -0.167883845939471 0.439301160240788 no 1915 0.433337329410747 2697 1103340 SGTC_3168 9103419 49.47 µM -0.16839741801176 0.439092959297337 no 1916 0.433135319614082 2685 16649256 SGTC_2621 lithochol-11-enic acid 100 µM -0.169388455939989 0.438691242465116 no 1917 0.432745551563055 2711 6708711 SGTC_2104 5389443 200 µM -0.16939648977913 0.43868798620908 no 1918 0.432742392179044 2862 2244536 SGTC_2760 etidronate 98.04 µM -0.170780909373968 0.438126918805086 no 1919 0.43219802032309 2745 3305 A chelator and antioxidant. SGTC_1644 st010134 20.9 µM -0.171612298188544 0.437790039341538 no 1920 0.431871169171525 2735 3818134 SGTC_3121 9125696 49.47 µM -0.171624667981979 0.437785027430375 no 1921 0.431866306478026 2655 1235365 SGTC_1783 st039459 87.517 µM -0.171803231545834 0.437712679337914 no 1922 0.431796112448138 2945 729761 SGTC_2673 kobusone 100 µM -0.171995462420624 0.437634796027352 no 1923 0.431720548152247 2717 6710676 An epoxy ketone and protein crosslinker. SGTC_88 0180-0332 8.668 µM -0.172405340557828 0.437468739900352 no 1924 0.431559436944151 2682 3101745 SGTC_1570 verbenone 133 µM -0.17300613552445 0.437225356526134 no 1925 0.431323302448659 2862 29025 A natural terpanoid with antifungal properties. SGTC_1418 3966-3099 2.4 µM -0.174986263891653 0.436423370777836 no 1926 0.43054521344119 2775 740335 SGTC_2921 7974240 10.71 µM -0.175081808623331 0.436384680113973 no 1927 0.430507676049727 2848 2979074 YDR527W RBA50 SGTC_441 propafenone 146 µM -0.175455539522086 0.436233344322064 no 1928 0.430360851560372 2700 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2949 9072542 2.23 µM -0.178568963263235 0.434972982674683 no 1929 0.429138083232907 2818 16457352 SGTC_2193 5925765 200 µM -0.179022808668538 0.434789313948408 no 1930 0.428959896137304 2834 877370 SGTC_2891 9063876 19.48 µM -0.17938497266937 0.434642758272426 no 1931 0.428817715037681 2812 6472478 SGTC_1235 benzylparaben 21.5 µM -0.181530246299182 0.43377482249093 no 1932 0.427975697202079 2812 7180 SGTC_2881 9058953 51.95 µM -0.181818663574492 0.433658158750267 no 1933 0.427862518617716 2706 17122249 SGTC_1805 st050013 60.3 µM -0.182265935699342 0.433477250234489 no 1934 0.427687015124142 2788 4037144 SGTC_2962 9082311 13.18 µM -0.182933779482663 0.433207152874604 no 1935 0.427424988954286 2728 16459453 SGTC_1631 benzylvanillin 81.9 µM -0.183119403072365 0.433132086300244 no 1936 0.427352165868978 2870 75506 SGTC_2462 5162487 171.77 µM -0.184788246254393 0.432457311235121 no 1937 0.426697563612035 2701 2259986 SGTC_858 0438-0351 2.77 µM -0.185826661062784 0.432037540967054 no 1938 0.426290348081698 2745 2799119 SGTC_365 0121-0052 13.6 µM -0.187047795664954 0.43154400597578 no 1939 0.42581157933655 2865 3101739 SGTC_726 3448-4391 34.2 µM -0.187661343339964 0.431296074208507 no 1940 0.42557106768025 2915 1356692 SGTC_3149 9097855 49.47 µM -0.188606102295519 0.430914354463044 no 1941 0.425200774858208 2887 25236625 YMR079W SEC14 SGTC_803 4488-1585 147 µM -0.189352482174833 0.430612833269524 no 1942 0.424908282204696 2864 747204 SGTC_1321 1326-2144 215 µM -0.18956068531752 0.430528730948094 no 1943 0.424826698559356 2865 3513030 SGTC_2911 7942208 15.64 µM -0.191454401704532 0.429763921515929 no 1944 0.424084800920672 2836 1243384 SGTC_496 calpeptin 138 µM -0.192715140452943 0.429254896748825 no 1945 0.423591032679456 2815 73364 A calpain inhibitor. SGTC_1572 epiandrosterone 68.9 µM -0.193101933867094 0.429098751986807 no 1946 0.423439569077363 2739 441302 A steroid. SGTC_547 1120-0019 610 nM -0.193594580204914 0.428899891489792 no 1947 0.423246671139066 2723 3676939 SGTC_1540 guanosine 70.6 µM -0.194488769096099 0.428538991381225 no 1948 0.422896594398392 2725 6802 Guanosine is a purine nucleoside SGTC_1395 3486-0190 4.35 µM -0.194506200189841 0.428531956677887 no 1949 0.42288977069435 2848 6748079 SGTC_996 3970-0799 1.8 µM -0.196943186161584 0.427548681601835 no 1950 0.421935998885931 2831 6615648 YGL040C HEM2 SGTC_1560 lithocholic acid 53.1 µM -0.197009503925233 0.427521929971053 no 1951 0.42191005024032 2748 9903 A bile acid which acts as a detergent. SGTC_1529 apigenin 74 µM -0.199678097209269 0.426445735663322 no 1952 0.420866172345335 2995 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1686 st019653 115.5 µM -0.199894644577013 0.426358430022251 no 1953 0.420781489463302 2860 97252 SGTC_2961 9083290 32.55 µM -0.200275667195428 0.426204821476405 no 1954 0.420632495891094 2785 17741490 SGTC_2202 7226349 200 µM -0.200333801647765 0.426181385665995 no 1955 0.420609764224765 2739 844334 SGTC_607 4491-0986 66.8 µM -0.20063668445952 0.426059288379554 no 1956 0.420491335622364 2883 698981 YDR232W HEM1 SGTC_2866 9034245 58.44 µM -0.202564864159587 0.425282172541384 no 1957 0.419737577474062 2860 6462273 SGTC_3231 9132313 49.47 µM -0.203409031567363 0.424942038222961 no 1958 0.419407670600536 2824 4905967 SGTC_744 1594-0068 283 µM -0.203809790533446 0.424780582829658 no 1959 0.41925107084402 2811 668392 SGTC_1295 1013-0063 9.78 µM -0.204534424751451 0.424488678550001 no 1960 0.418967946742807 2862 6826038 SGTC_2830 7992007 71.43 µM -0.206107702819056 0.423855057974024 no 1961 0.418353390985366 2661 1952075 SGTC_1579 chlormadinone acetate 49.4 µM -0.206960897750401 0.423511525222405 no 1962 0.418020198194173 2934 45114258 A steroidal progestin. SGTC_1600 coumarin 106 71.1 µM -0.207695874760658 0.423215638657083 no 1963 0.417733219454408 2932 100336 A hepatotoxic, DNA x-linker. SGTC_1737 st035557 69.7 µM -0.207743382572743 0.423196514481239 no 1964 0.417714671084547 2705 5716916 SGTC_2941 9056145 11.23 µM -0.208557117445516 0.42286897524842 no 1965 0.417396994835019 2745 2119517 SGTC_586 0957-0265 8.15 µM -0.208795707090255 0.422772949804025 no 1966 0.417303861362685 2796 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_424 splitomicin 100 mM -0.209468576548244 0.422502164007939 no 1967 0.417041231765722 2860 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_336 4111-0029 111 µM -0.210415817418341 0.422121023817543 no 1968 0.416671574236783 2827 3131175 SGTC_3270 9137563 49.47 µM -0.21054659503222 0.422068408704431 no 1969 0.416620544498127 2894 17015724 SGTC_2324 6149169 200 µM -0.210678093234844 0.422015505082789 no 1970 0.416569235000723 2854 2888231 SGTC_1423 4048-0112 5.59 µM -0.211721755196691 0.421595674817743 no 1971 0.41616205732327 2861 X1423 SGTC_389 tpck 16.7 µM -0.211804809078551 0.421562268843184 no 1972 0.416129658270111 2849 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_857 0438-0306 1.35 µM -0.212004804159287 0.421481829037023 no 1973 0.416051643169027 2879 4686136 SGTC_2754 granisetron 64.02 µM -0.21465200526438 0.420417411105393 no 1974 0.415019322257966 2919 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2480 5767542 37.17 µM -0.214703067173136 0.420396885222683 no 1975 0.414999415544437 2826 2867358 SGTC_869 0564-0080 44.1 µM -0.21605535169126 0.419853372395388 no 1976 0.414472300951361 2824 6843321 SGTC_942 3253-1115 227 µM -0.216951113222855 0.419493430259176 no 1977 0.414123221748107 2960 46497897 SGTC_1353 1498-1206 8.11 µM -0.217722185349 0.419183645756722 no 1978 0.413822788452403 2792 6756808 SGTC_2531 methyl deoxycholate 70.07 µM -0.218194632227252 0.418993861114925 no 1979 0.413638733597511 2794 16667744 Haematoxylin. SGTC_2605 digitonin 300 nM -0.218402962457739 0.418910179642792 no 1980 0.413557578772518 2838 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2728 chlorpromazine 9.18 µM -0.218714187126889 0.418785174671388 no 1981 0.413436348405179 2757 2726 A thorazine and dopamine antagonist. SGTC_2625 euphol 100 µM -0.219076856095351 0.418639517181197 no 1982 0.413295089512865 2929 6708538 A triterpene alcohol. SGTC_1522 st012842 45.6 µM -0.219328353005299 0.418538515890591 no 1983 0.413197138520436 2741 3491067 YOR116C RPO31 SGTC_3303 9125618 40.5795 µM -0.219591559084409 0.418432817942779 no 1984 0.413094632921177 2884 22695467 SGTC_1818 st052136 56.3 µM -0.221187080519273 0.417792216887887 no 1985 0.41247338419938 2869 674169 SGTC_2686 alizarin 95.37 µM -0.222341903126996 0.417328692130828 no 1986 0.412023867190021 2866 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.223809481636772 0.416739798670156 no 1987 0.411452775914735 2769 1241132 A phosphatase inhibitor. SGTC_2375 9072683 200 µM -0.223980699598637 0.416671106387269 no 1988 0.411386160611099 2942 16798029 SGTC_138 0850-0259 40.9225 µM -0.225127044673382 0.41621126082141 no 1989 0.410940221170964 2891 6813004 SGTC_1691 st019933 84.6 µM -0.225843293528472 0.415924002482404 no 1990 0.41066165173896 2787 6176082 SGTC_3001 9076041 71.4286 µM -0.227892126946184 0.415102547069447 no 1991 0.409865051741514 2799 16004211 SGTC_1980 st071811 45.7 µM -0.229094162351197 0.414620777707055 no 1992 0.409397865295073 2958 4974850 SGTC_2200 6600604 21.907 µM -0.229095869123298 0.414620093733043 no 1993 0.409397202027552 2811 2904777 SGTC_895 0964-0006 13.7 µM -0.229238248786068 0.414563037238423 no 1994 0.409341872879087 2911 6738897 SGTC_577 r071-0003 38.6 µM -0.229398902510576 0.414498659854719 no 1995 0.409279444545857 2817 4568517 YMR134W ERG29 SGTC_3123 9126162 49.47 µM -0.229405757127234 0.414495913114282 no 1996 0.409276780965698 2787 25239884 SGTC_1088 bifonazole 369 nM -0.231748898809435 0.413557229449343 no 1997 0.408366524668425 2792 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_447 ml7 120 µM -0.231879255904059 0.413505021674025 no 1998 0.408315898421827 2877 4216 Selective myosin light chain kinase inhibitor. SGTC_2913 7966556 36.57 µM -0.232788870285333 0.4131407654083 no 1999 0.407962677879162 2901 2976516 SGTC_1782 st039423 80.636 µM -0.232965233893091 0.41307014901454 no 2000 0.407894201187344 2867 2068169 SGTC_2650 prasterone 100 µM -0.233142715011388 0.412999088006339 no 2001 0.407825293439965 2826 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2141 5621638 7.665 µM -0.234853049297039 0.412314440018148 no 2002 0.407161395809746 2959 2856238 SGTC_819 1013-0258 27.7 µM -0.235234894670476 0.412161623404803 no 2003 0.407013211865029 2842 5753198 SGTC_2004 4023728 41.89 µM -0.235772610560315 0.41194644914227 no 2004 0.406804561327857 2968 360084 YDR527W RBA50 SGTC_418 lividomycin a 100 µM -0.235820359833176 0.4119273429058 no 2005 0.406786034398507 2924 72394 An antibiotic. SGTC_2199 6590217 200 µM -0.235938157520597 0.411880208620861 no 2006 0.406740329266308 2887 703109 SGTC_836 0330-0104 1.35 µM -0.237587390057069 0.411220436458885 no 2007 0.406100565889937 2828 46494820 SGTC_286 k060-0067 22.9 µM -0.237714998633863 0.411169397343178 no 2008 0.40605107493096 2853 5985051 SGTC_2048 5246248 200 µM -0.241073528923703 0.409826641860447 no 2009 0.404749064335587 2932 677046 SGTC_2713 st079149 53.4 µM -0.241196321077088 0.409777568937315 no 2010 0.404701481050005 2910 3103253 SGTC_116 0155-0182 31.788 µM -0.241277878662124 0.409744975867742 no 2011 0.404669877383802 2852 771486 SGTC_1328 1441-0025 69.2 µM -0.241510931398499 0.409651843835403 no 2012 0.404579572585206 2801 4562601 SGTC_2935 9038016 29.96 µM -0.242605259360422 0.409214599103734 no 2013 0.404155603271412 2965 6463195 SGTC_2654 protoveratrine a 100 µM -0.24282794855343 0.409125636227276 no 2014 0.404069341818378 2838 5702278 A heart drug and vasodilator. SGTC_2116 5511452 16.8835 µM -0.243586934836413 0.408822461358121 no 2015 0.403775374023793 2966 870744 SGTC_582 0987-0078 156 µM -0.243964781120141 0.408671552081356 no 2016 0.403629048232515 2877 1625765 SGTC_812 4251-0442 148 µM -0.244302451509521 0.408536700244018 no 2017 0.403498292480903 2905 5723007 SGTC_2328 6201408 200 µM -0.244909152459362 0.408294435746368 no 2018 0.40326338741592 2970 2890418 SGTC_1397 3532-0190 20.1 µM -0.244976817239488 0.408267418387997 no 2019 0.403237190839172 2798 5322280 SGTC_2159 5658611 73.75 µM -0.245038542760351 0.408242772851874 no 2020 0.403213294039174 2896 793844 SGTC_677 0929-0063 136 µM -0.245947811158623 0.407879765656495 no 2021 0.402861316169747 2836 1539583 SGTC_1094 duloxetine 25.4 µM -0.248995168305488 0.406663747581042 no 2022 0.401682259436497 2832 60834 A selective serotonin reuptake inhibitor. SGTC_486 niguldipine 82 µM -0.250111679116655 0.406218439376012 no 2023 0.401250492166264 2824 1236 A calcium channel blocker. SGTC_733 4069-0007 56.1 µM -0.250534858287359 0.406049690626921 no 2024 0.401086875506522 2864 5717425 YNL287W SEC21 SGTC_1958 st076513 41.9 µM -0.250569334634754 0.406035943458559 no 2025 0.401073546444092 2830 732122 YGL099W LSG1 SGTC_2445 5742597 35.57 µM -0.250600105483029 0.406023673926244 no 2026 0.40106165007931 2849 1774255 SGTC_2395 5646831 180.19 µM -0.251395688699593 0.405706476075642 no 2027 0.400754100311296 3032 6808628 SGTC_301 4119-0100 24.5 µM -0.253272940170075 0.404958264410038 no 2028 0.400028652577219 2875 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_923 1900-2434 73.3 µM -0.254025334679974 0.404658481654341 no 2029 0.399737992837742 2820 5910570 SGTC_3174 9107204 49.47 µM -0.255204093106066 0.404188931769172 no 2030 0.399282734939072 2981 3938802 SGTC_196 k015-0023 18.111 µM -0.256062928023321 0.403846907954914 no 2031 0.398951123501222 2842 5211998 SGTC_2634 4'-methoxyflavone 100 µM -0.258446635556273 0.402898002280415 no 2032 0.398031114387823 2935 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1165 k072-0275 30.3 µM -0.258796424594041 0.402758806314206 no 2033 0.397896158342172 2930 6153523 YGL055W OLE1 SGTC_779 1360-0071 233 µM -0.259584111319453 0.40244539734717 no 2034 0.397592296813634 3054 7566 SGTC_2785 7756463 72.73 µM -0.26229082568109 0.401368914541542 no 2035 0.396548617274248 2870 2201551 SGTC_1966 st070145 16.1 µM -0.26274069639773 0.401190069508011 no 2036 0.396375223624502 2821 3748532 SGTC_3016 9080866 49.47 µM -0.263698924878362 0.4008091971069 no 2037 0.396005962021568 2896 17066299 SGTC_187 1488-2104 32.728 µM -0.2651703138122 0.400224539597437 no 2038 0.395439131341126 2928 2852859 SGTC_1591 genipin 88.4 µM -0.26528153430126 0.400180355122441 no 2039 0.39539629427795 3014 442424 A DNA cross-linking agent. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.266039444688368 0.399879294714248 no 2040 0.395104415418133 2897 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_590 k048-0076 22.4 µM -0.266210350440997 0.399811415015107 no 2041 0.395038606031282 2991 6832814 SGTC_1610 st001799 48.1 µM -0.267175426070326 0.39942816680862 no 2042 0.394667047891108 2842 621897 SGTC_2600 tangeritin 87.95 µM -0.268357685332479 0.398958803317953 no 2043 0.394212003733289 2855 68077 A bioactive flavone. SGTC_777 1315-0167 517 µM -0.269162906805368 0.398639209498565 no 2044 0.393902161651364 2979 4221767 SGTC_394 menadione 8.33 µM -0.270117515684137 0.398260411609858 no 2045 0.393534923623395 3016 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_840 0245-0196 390 µM -0.270400139204424 0.398148282281809 no 2046 0.393426216509002 3022 3827528 SGTC_1399 3562-5772 25 µM -0.271017864368697 0.397903232511763 no 2047 0.393188646249128 2839 23847490 SGTC_865 0488-0499 301 µM -0.271334590752833 0.397777603691308 no 2048 0.393066852205723 3002 9634651 SGTC_1352 1496-0991 99 µM -0.271373118888533 0.397762322314271 no 2049 0.393052037300535 2874 3000039 SGTC_1923 st058458 19.1 µM -0.271521769723483 0.397703364548383 no 2050 0.392994879276998 3128 3534982 SGTC_1243 0416-0003 5.65 µM -0.271741222002271 0.397616329845973 no 2051 0.392910501468855 2926 2141977 SGTC_2946 9065502 71.43 µM -0.272045347136115 0.397495722342689 no 2052 0.392793575881689 2909 16489101 SGTC_570 0987-0065 62.6 µM -0.272118872787592 0.397466565600667 no 2053 0.392765309265332 2822 3104428 SGTC_2127 5253358 187.912 µM -0.272351980261415 0.397374130160386 no 2054 0.392675695852171 2821 20612 SGTC_106 0092-0003 11.579 µM -0.272632819065738 0.397262775197043 no 2055 0.392567740658842 2944 1072148 SGTC_161 4065-0411 162.148 µM -0.272933194305397 0.397143683139506 no 2056 0.392452284755147 3016 1906281 YLR208W SEC13 SGTC_1362 1611-0397 101 µM -0.273876747337778 0.396769647910714 no 2057 0.39208967077067 2902 27816 SGTC_1752 st044819 83.042 µM -0.274751114794993 0.396423123394319 no 2058 0.391753728917198 2908 441209 YML126C ERG13 SGTC_918 glabranin 770.725 nM -0.275965008317526 0.39594217543811 no 2059 0.391287471145738 2939 124049 Also referred to as licorice root. SGTC_1998 st075797 76.8 µM -0.277162622979073 0.395467832396163 no 2060 0.390827619138182 3005 24208315 SGTC_2266 7929956 200 µM -0.277223837616199 0.395443591073441 no 2061 0.390804118448878 2846 2967153 SGTC_1188 1403-0014 4.57 µM -0.277279856165004 0.395421407783895 no 2062 0.390782612920457 2908 9614867 SGTC_1302 1159-0335 255 µM -0.277320566014291 0.395405286936713 no 2063 0.39076698461342 2900 649284 SGTC_2553 4-methylesculetin 85.09 µM -0.277603820998972 0.395293124680647 no 2064 0.390658249330948 2947 5319502 SGTC_1878 temozolomide 1 mM -0.277606953330618 0.395291884400077 no 2065 0.390657046946346 2983 5394 DNA alkylating agent. SGTC_2292 7671323 168.05 µM -0.277694091572707 0.395257381496535 no 2066 0.390623598263558 3048 937504 SGTC_2903 5923464 63.88 µM -0.278093254251332 0.395099341167354 no 2067 0.390470386956017 2975 2876576 SGTC_1313 1220-0047 237 µM -0.279169772267262 0.394673201884197 no 2068 0.390057270010274 2949 3528706 SGTC_2061 5245884 80.95 µM -0.279351744017004 0.394601180865365 no 2069 0.389987450070867 2887 573863 SGTC_646 4092-0839 27.3 µM -0.279373301211517 0.394592649169127 no 2070 0.389979179120911 3033 877796 SGTC_1900 st060200 72.8 µM -0.281662055702807 0.393687116648721 no 2071 0.389101326045055 2873 688945 SGTC_2307 7538926 6.34 µM -0.282115578501853 0.39350775102558 no 2072 0.388927444142449 2940 96582 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.283814953989337 0.392835859184604 no 2073 0.388276096972392 3012 7104 SGTC_578 3460-0051 92 µM -0.28410601733349 0.392720811760426 no 2074 0.388164567865429 2996 2876744 SGTC_3026 9090633 49.47 µM -0.284857115824126 0.392423971436652 no 2075 0.387876805979417 2893 25236842 SGTC_987 1497-1013 404 µM -0.28594378332615 0.391994622268178 no 2076 0.387460589433574 2905 1676435 SGTC_992 3909-8734 162 µM -0.286187202715757 0.39189846374207 no 2077 0.38736737239053 2952 4288319 SGTC_3096 9117468 49.47 µM -0.286575374342195 0.39174513706621 no 2078 0.387218736159582 3040 41316311 SGTC_1343 1487-0095 224 µM -0.287877996731322 0.391230727978421 no 2079 0.386720065163666 3040 4560101 YGL055W OLE1 SGTC_2801 7907800 81.82 µM -0.288341718711406 0.391047648780491 no 2080 0.38654258781186 3006 6620925 SGTC_1200 1643-0193 18.4 µM -0.289955873323566 0.39041056292905 no 2081 0.385924998005807 2996 5403974 SGTC_47 0149-0135 24.25 µM -0.291151087283327 0.389939016943819 no 2082 0.385467884722898 2899 5239155 SGTC_2463 5473429 200 µM -0.292163754549804 0.389539617519999 no 2083 0.385080711425804 2980 5399405 SGTC_3239 9133757 49.47 µM -0.29283490793254 0.38927497657816 no 2084 0.384824172292522 2907 17036923 SGTC_1624 st003710 6.25 µM -0.293341290222794 0.389075340125342 no 2085 0.384630648001714 3078 24207033 SGTC_3225 9130819 49.47 µM -0.297669762642582 0.387370080541926 no 2086 0.382977611854707 3058 4547121 SGTC_203 k066-0004 30.888 µM -0.30005946722058 0.386429552395762 no 2087 0.382065897940019 2993 6795412 SGTC_1229 0139-0193 12.2 µM -0.300364611284688 0.386309503195856 no 2088 0.381949527117825 3083 3090752 SGTC_2417 cerulenin 830 nM -0.305146518183366 0.384429642860449 no 2089 0.380127281611832 3050 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2724 maprotiline 69.64 µM -0.305429117184068 0.384318632242153 no 2090 0.380019674141508 3050 4011 A tricyclic antidepressant. SGTC_2886 9058944 51.95 µM -0.305926017591794 0.384123462697915 no 2091 0.379830487946475 2981 4949929 SGTC_525 k781-2675 26.7 µM -0.306269729936901 0.383988478623271 no 2092 0.379699642266983 2952 3651118 YDL195W SEC31 SGTC_1705 st027868 56.3335 µM -0.308569495318422 0.383085668476116 no 2093 0.37882451419221 3020 292948 SGTC_2977 9011197 71.43 µM -0.309410319077339 0.382755747673455 no 2094 0.378504710887043 3155 2704722 SGTC_502 l-744,832 89.3 µM -0.309441745600385 0.382743418242534 no 2095 0.378492759570403 3065 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_78 0336-0123 156.75 µM -0.309741796652978 0.382625706504898 no 2096 0.378378657823559 2875 6765896 SGTC_2058 5236698 133 µM -0.310288754616402 0.382411159682941 no 2097 0.37817069097811 2979 766665 SGTC_2396 5342950 42.78 µM -0.310807984941792 0.382207522548098 no 2098 0.377973299514239 3043 1886677 SGTC_2257 7960413 200 µM -0.310905109832739 0.382169434716075 no 2099 0.377936379889117 2943 2974689 YIL048W NEO1 SGTC_390 dec-rvkr-cmk 16.7 µM -0.311054696193277 0.382110776183899 no 2100 0.377879520514676 2999 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_72 0744-0168 198.391 µM -0.311472118758299 0.381947103148391 no 2101 0.377720867731632 2913 677577 SGTC_2068 5226020 147 µM -0.313957247662975 0.380973111933258 no 2102 0.376776754782608 3007 1810509 SGTC_1342 1486-1464 234 µM -0.317269198292582 0.379676238621215 no 2103 0.375519673574888 2972 3253938 SGTC_1339 1486-1321 22.7 µM -0.318922861216085 0.379029212670891 no 2104 0.374892504047694 2988 3469382 SGTC_1682 st012968 530 nM -0.318991852440749 0.379002225938663 no 2105 0.374866345555513 2968 24207270 SGTC_3279 9140807 49.47 µM -0.319719349801341 0.378717692678033 no 2106 0.374590545044555 2962 45595718 SGTC_3329 9141233 27.5565 µM -0.320072854788028 0.378579456201912 no 2107 0.374456551409955 3126 4909101 YNL103W MET4 SGTC_2282 7944268 200 µM -0.322965380235121 0.377448932703291 no 2108 0.373360730402945 3174 2970414 SGTC_1842 st055362 61.2 µM -0.323867812199954 0.37709643772394 no 2109 0.373019056906877 2977 676032 SGTC_2933 9026794 32.47 µM -0.324033736266688 0.377031637989867 no 2110 0.372956246569484 3017 17586027 SGTC_2518 prenyletin 46.28 µM -0.324122140173946 0.376997114275635 no 2111 0.372922782765389 3071 3873459 A coumarin with calcium channel inhibitory activity. SGTC_378 3970-0959 8.33 µM -0.329841723125802 0.374765589955058 no 2112 0.370759779730918 3115 6615653 SGTC_900 1112-0045 141 µM -0.329924391927042 0.374733366821345 no 2113 0.370728546196792 3027 56211 YIL048W NEO1 SGTC_2869 9037858 32.47 µM -0.331385609524508 0.374163949340888 no 2114 0.370176616674668 2943 27187042 SGTC_1428 4049-0204 61.7 µM -0.332941399745316 0.373557979786212 no 2115 0.369589259002646 3100 X1428 SGTC_622 1348-1566 26.3 µM -0.333606214140542 0.373299134374439 no 2116 0.369338364226673 3062 7340407 SGTC_2489 cantharidin 73.42 µM -0.333764562699273 0.373237489805731 no 2117 0.369278613152539 2958 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3272 9137413 49.47 µM -0.334896895783054 0.372796770933495 no 2118 0.368851431917936 2954 17614870 SGTC_995 3931-2021 34.6 µM -0.335370655552292 0.372612426780391 no 2119 0.368672750485724 3096 730143 SGTC_1440 4100-1550 40 µM -0.336115771037237 0.372322554739343 no 2120 0.368391783011274 3030 742806 SGTC_2890 9046729 58.44 µM -0.336582175786051 0.372141146240389 no 2121 0.368215947324756 3004 903329 SGTC_1167 k781-0610 148 µM -0.337400487325282 0.37182293189865 no 2122 0.367907508667322 3028 4525169 SGTC_2268 7933382 153.85 µM -0.340179359640833 0.370742974802205 no 2123 0.366860730453422 2940 935025 YOR257W CDC31 SGTC_1486 3970-0793 4.53 µM -0.340351030867197 0.370676291256368 no 2124 0.366796095687568 3083 2844330 SGTC_3293 9120939 62.045 µM -0.340738733372431 0.370525707351893 no 2125 0.36665013835164 3162 934087 SGTC_2361 9034121 116 µM -0.340925398475991 0.370453213577049 no 2126 0.366579871909112 3026 6496917 SGTC_455 paf C-16 10 µM -0.341655128136303 0.370169857917543 no 2127 0.366305222320344 2994 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3171 9103192 49.47 µM -0.341824692344266 0.370104025837413 no 2128 0.366241412950281 3101 13018434 SGTC_1125 tnp00248 1.32998 µM -0.341901902622131 0.370074050764979 no 2129 0.366212358874067 3172 24207736 SGTC_2443 5493264 126.67 µM -0.344088780828048 0.369225375154511 no 2130 0.365389759974662 3164 5340055 SGTC_1775 st081588 35.1725 µM -0.34436189002505 0.369119432606298 no 2131 0.36528707275893 3029 1426443 YGL099W LSG1 SGTC_169 k015-0017 16.025 µM -0.344438983450025 0.36908952888021 no 2132 0.365258087898663 3250 1840002 SGTC_3070 9117005 49.47 µM -0.345119368585899 0.368825649035397 no 2133 0.365002316486636 3081 8779016 SGTC_1282 0886-0010 32.4 µM -0.345169227365847 0.36880631428929 no 2134 0.364983575858743 3194 2836211 YNL267W PIK1 SGTC_2386 9075165 157.42 µM -0.345496111879925 0.368679559905964 no 2135 0.364860716401618 3001 16452277 SGTC_2347 9049783 174.81 µM -0.345733930888254 0.368587350987533 no 2136 0.364771340909396 3172 6467988 YPL169C MEX67 SGTC_287 k060-0039 29.6 µM -0.346874374647051 0.368145275048613 no 2137 0.364342849425449 3149 5861974 SGTC_1936 st074407 74.3 µM -0.347245735209068 0.368001360332893 no 2138 0.364203357101149 3020 809813 SGTC_391 gliotoxin 8.33 µM -0.348320973756023 0.367584773743857 no 2139 0.363799572078689 3183 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3126 9127922 49.47 µM -0.348545182393178 0.367497926758517 no 2140 0.363715393902775 3237 45595682 SGTC_2919 7978188 46.38 µM -0.348979040339178 0.367329891575208 no 2141 0.363552522471904 3202 2980291 SGTC_2808 7946468 45.46 µM -0.349404072179901 0.367165299416027 no 2142 0.363392988295057 3087 2970879 SGTC_152 4469-0003 551.229 µM -0.349976147007538 0.366943803891304 no 2143 0.363178299466909 3032 697280 SGTC_1641 st009299 47.1 µM -0.350547794219952 0.366722518165547 no 2144 0.36296381404554 3102 4046054 SGTC_2805 7950783 58.44 µM -0.351778073117284 0.366246425165431 no 2145 0.362502351968652 3136 1178958 YDL195W SEC31 SGTC_3007 9078383 71.4286 µM -0.352737014669565 0.365875476905355 no 2146 0.362142803542913 3038 6496995 SGTC_2588 indole-3-carbinol 100 µM -0.353743831881555 0.365486143758062 no 2147 0.361765435334719 3152 3712 Induces cell cycle arrest. SGTC_3162 9099653 49.47 µM -0.353792936507151 0.365467158689415 no 2148 0.361747033715351 3160 25237511 SGTC_154 3389-1638 511.116 µM -0.353986278501046 0.365392411073664 no 2149 0.361674583245917 3092 5238686 SGTC_2982 9019404 25.97 µM -0.354922795338366 0.365030418314333 no 2150 0.361323715301417 3036 22333232 SGTC_853 0419-0306 21 µM -0.356142207746134 0.364559257918637 no 2151 0.360867034755793 3016 762713 SGTC_40 0327-0103 19.753 µM -0.356278021604994 0.364506794379084 no 2152 0.360816183546356 3044 409036 SGTC_458 nppb 133 µM -0.358244192049283 0.363747567110513 no 2153 0.360080289190654 3224 4549 A chloride channel blocker. SGTC_1554 st069299 38.7 µM -0.359332850540168 0.36332741665199 no 2154 0.359673050980488 3110 24207999 SGTC_3169 9102970 49.47 µM -0.359480320759651 0.363270515492669 no 2155 0.359617898530286 3070 17027839 SGTC_1668 st014914 51.6 µM -0.361936144310167 0.362323384090238 no 2156 0.358699874583484 3117 2839556 SGTC_2168 5727979 200 µM -0.362453956551245 0.362123788033357 no 2157 0.358506412500944 3053 695210 SGTC_2152 5568786 200 µM -0.365036292796706 0.361128960529005 no 2158 0.357542157524986 3082 5399883 SGTC_3068 9116768 49.47 µM -0.365331671202619 0.361015227695383 no 2159 0.357431919812192 3158 41904888 SGTC_52 0329-0193 875 nM -0.365433515801029 0.360976016184738 no 2160 0.357393913306286 3247 3739292 SGTC_1806 st050005 60.3 µM -0.365603799684366 0.360910457912619 no 2161 0.357330369694657 3052 5194765 SGTC_2360 9040895 200 µM -0.365886409381404 0.360801663896285 no 2162 0.357224918998732 3096 4914414 SGTC_2277 7947813 106.88 µM -0.366378044378832 0.360612429910289 no 2163 0.357041500279882 3250 1246798 SGTC_3301 9125354 19.7965 µM -0.366783262720913 0.360456483996049 no 2164 0.356890346638642 3035 41905162 SGTC_1880 MG-132 525 µM -0.367189592408226 0.360300133691018 no 2165 0.356738801002291 3174 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_507 nimesulide 162 µM -0.367269147034876 0.360269524853593 no 2166 0.356709132775298 3249 4495 A COX2 inhibitor. SGTC_533 1222-0222 6.71 µM -0.368919693407359 0.35963467541248 no 2167 0.356093791972949 3219 3982874 SGTC_1698 5-fluorocytosine 1.055 µM -0.370924365021155 0.358864139588091 no 2168 0.355346933496645 3189 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3322 9139058 2.11 µM -0.370950849743649 0.35885396348755 no 2169 0.355337070084485 3229 4908926 YPR165W RHO1 SGTC_979 1426-2828 121 µM -0.372575560757983 0.358229900223739 no 2170 0.354732182473845 3194 747872 SGTC_2088 5278280 127.392 µM -0.374338203548161 0.35755328447905 no 2171 0.354076356230381 3153 791502 SGTC_1148 3909-7663 27.7 µM -0.376719607483586 0.356639859328335 no 2172 0.353190994969618 3169 4084526 SGTC_1971 st069429 63.5 µM -0.377002765673865 0.356531304074901 no 2173 0.353085774800385 3184 1246522 YGL099W LSG1 SGTC_2192 5915882 198.485 µM -0.377131392616129 0.356481995794241 no 2174 0.353037981380564 3102 2876149 SGTC_3283 9109332 35.8195 µM -0.377361768691557 0.35639368865804 no 2175 0.352952387220461 3084 17027281 SGTC_3157 9099274 49.47 µM -0.377912619949009 0.356182569061772 no 2176 0.352747753561053 3219 17217662 SGTC_642 0335-0876 158 µM -0.379702725204453 0.355496796875154 no 2177 0.352083048499997 3094 6812350 SGTC_3022 9087993 49.47 µM -0.380294554177643 0.355270175592353 no 2178 0.351863388769878 3161 17173644 SGTC_2740 felodipine 17.08 µM -0.381869785150756 0.354667242671433 no 2179 0.351278976451397 3140 3333 L-type calcium channel blocker SGTC_357 1325-0123 420 µM -0.382352066317318 0.354482718188078 no 2180 0.351100119853476 3195 1098503 SGTC_2765 myclobutanil 7.74 µM -0.384863823198438 0.353522253610222 no 2181 0.350169155065465 3181 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_601 0986-0029 62.9 µM -0.385100878744934 0.35343165455061 no 2182 0.350081338492007 3101 24747981 SGTC_1014 4130-3005 69.3 µM -0.385144804100344 0.353414867853076 no 2183 0.35006506734543 3069 743608 SGTC_1422 4031-0024 15.5 µM -0.385990923604412 0.353091566966069 no 2184 0.349751695415394 3140 782427 SGTC_741 4582-0002 126 µM -0.386623256466847 0.352850022812053 no 2185 0.349517569093867 3058 2912688 SGTC_2020 4017018 200 µM -0.386961388865541 0.352720884304268 no 2186 0.349392396336359 3184 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_546 peri-Naphthalide 147 µM -0.387247608810284 0.352611585304871 no 2187 0.349286453775325 3114 223824 A penicillin ester. SGTC_2710 st078562 53.7235 µM -0.389035721235801 0.351929033377037 no 2188 0.348624861009595 3044 17250908 SGTC_2842 9000675 19.48 µM -0.390022894443725 0.351552417281421 no 2189 0.348259808792151 3138 2989072 SGTC_337 1315-0038 354 µM -0.390639208582495 0.351317361331617 no 2190 0.34803196982669 3110 1626437 SGTC_1700 st030840 7.9285 µM -0.391197125670453 0.351104626451429 no 2191 0.347825766374671 3192 5499307 SGTC_462 ag-879 158 µM -0.394189612932037 0.349964382840053 no 2192 0.346720526920917 3190 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_822 1487-0950 154 µM -0.394640931071772 0.349792531691189 no 2193 0.346553950821815 3251 1958375 SGTC_2541 muurolladie-3-one 83.07 µM -0.395012666995831 0.349651006652975 no 2194 0.346416769840992 3265 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1872 amphotericin b 148 nM -0.396718067636402 0.34900200494391 no 2195 0.345787687590529 3193 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_468 gf-109203x 121 µM -0.396805183101065 0.348968864401867 no 2196 0.345755564150211 3135 2396 A protein kinase C inhibitor. SGTC_3116 9124943 49.47 µM -0.397650046967202 0.348647520339284 no 2197 0.34544408199128 3122 41905195 YPL160W CDC60 SGTC_749 1000-0129 128 µM -0.398270143041041 0.348411735797289 no 2198 0.345215533190304 3271 708470 SGTC_2682 pyrogallin 40.03 µM -0.399100279741438 0.348096177363247 no 2199 0.344909658080649 3138 822798 An ATP competetive kinase inhibitor. SGTC_674 0498-0004 451 µM -0.399784182036824 0.347836285747519 no 2200 0.344657741131349 3179 4231473 SGTC_233 rapamycin 362 pM -0.400373191350264 0.347612511959973 no 2201 0.344440833419361 3175 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3304 9125678 46.087 µM -0.400884392914466 0.347418341571811 no 2202 0.344252620531195 3103 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2566 crystal violet carbinol 226 nM -0.40282156426821 0.34668290678822 no 2203 0.343539748054074 3229 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1746 st038117 42 µM -0.402946205093091 0.346635607433243 no 2204 0.343493899670006 3182 2898218 SGTC_2691 st077356 60.2 µM -0.403911044211187 0.346269546146207 no 2205 0.343139067301285 3265 2839272 SGTC_2689 tacrolimus 100 µM -0.405636971638846 0.345615085193321 no 2206 0.342504679660445 3169 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2762 leflunomide 42.06 µM -0.406315065493122 0.345358082292194 no 2207 0.342255558617781 3110 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3255 9139072 49.47 µM -0.408057638584008 0.344697960604875 no 2208 0.341615679623942 3191 17646060 SGTC_1477 0139-0234 16 µM -0.408204454517198 0.344642365338293 no 2209 0.341561789047018 3174 620880 SGTC_1499 4480-0877 67.3 µM -0.409430342186753 0.344178285542851 no 2210 0.34111193820267 3122 2861909 SGTC_667 1498-1044 59 µM -0.409529829340709 0.344140633337484 no 2211 0.341075440364669 3150 6739982 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.410273410192185 0.343859264460982 no 2212 0.340802697549251 3105 4000243 SGTC_2581 avocatin a 64 µM -0.410523778840153 0.343764545125521 no 2213 0.3407108819339 3143 6710728 A skin care supplement. SGTC_3057 9095946 49.47 µM -0.411975381562882 0.343215568958992 no 2214 0.340178733832734 3131 24540043 SGTC_1734 st037168 69.4 µM -0.418069922467126 0.340914317875409 no 2215 0.337947997507545 3198 708907 SGTC_2062 5245942 200 µM -0.418220106940617 0.340857683620204 no 2216 0.337893098064635 3194 1376160 SGTC_1046 2001-0062 216 µM -0.418844468349411 0.340622276680383 no 2217 0.337664901770678 3115 739778 SGTC_33 0986-0033 35.816 µM -0.42037087406389 0.340047027762546 no 2218 0.337107270949633 3214 2848082 SGTC_2867 9039098 71.43 µM -0.421258053985535 0.339712851608903 no 2219 0.336783328188222 3107 6463460 SGTC_2555 cholic acid 100 µM -0.421410954366712 0.339655270978326 no 2220 0.336727510730118 3297 6708657 Influences liver metabolism. SGTC_538 2922-0838 53.3 µM -0.421757779170827 0.339524674378978 no 2221 0.336600913005228 3302 777039 SGTC_2298 7976326 193.81 µM -0.422526725799381 0.339235196880522 no 2222 0.336320298749934 3158 2235818 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.422591259524603 0.339210906839298 no 2223 0.33629675238686 3146 6857784 SGTC_1899 st063254 59.6 µM -0.423576259185083 0.338840242868346 no 2224 0.335937436181255 3108 3093813 SGTC_2222 6885208 172.143 µM -0.424343164494489 0.338551757692882 no 2225 0.33565778197396 3192 609514 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.424511061624751 0.338488612809939 no 2226 0.335596569943235 3270 1377 SGTC_2260 7964312 200 µM -0.425798535019728 0.338004554508449 no 2227 0.335127327262677 3291 231951 SGTC_1553 gossypol 38.6 µM -0.426754060867047 0.337645473344906 no 2228 0.334779235020291 3159 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_182 3448-4371 550.524 µM -0.427549575601699 0.337346636136347 no 2229 0.334489542096804 3258 3491403 SGTC_1007 4101-0031 70 µM -0.4291075416353 0.33676167937786 no 2230 0.333922482088964 3275 1146276 SGTC_521 r062-0005 13.8 µM -0.430531347211646 0.336227439844053 no 2231 0.333404584473222 3157 2832033 SGTC_2299 7976368 114.88 µM -0.430787824430806 0.336131239711296 no 2232 0.333311326694628 3266 2979718 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.432459322309292 0.335504553107934 no 2233 0.332703805323044 3203 688788 SGTC_1550 gossypolone 36.6 µM -0.432662680956345 0.335428340007554 no 2234 0.332629922666681 3165 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1139 k015-0024 46.9 µM -0.433567126036317 0.335089461502937 no 2235 0.332301405608647 3270 2766652 SGTC_1841 st054148 70 µM -0.433699539744609 0.335039859840002 no 2236 0.332253320443743 3227 675442 SGTC_3315 9136395 68.55 µM -0.436993411395211 0.333806916065456 no 2237 0.331058063127138 3350 16876844 SGTC_3077 9117319 49.47 µM -0.437377215054113 0.333663369137772 no 2238 0.330918902747316 3227 17154678 SGTC_1427 4048-4900 550 nM -0.438016006557183 0.333424507847802 no 2239 0.330687340110494 3278 24132586 SGTC_1611 st001856 99.4 µM -0.438358096706373 0.333296618915391 no 2240 0.330563358678403 3207 647478 SGTC_1005 4092-0690 4.4 µM -0.438850286265934 0.333112649963023 no 2241 0.330385010345184 3180 1529343 SGTC_133 0724-0033 378.92 µM -0.439650539667056 0.332813619676945 no 2242 0.330095115164557 3080 280309 SGTC_1410 3909-8106 77.9 µM -0.440627357598232 0.332448756705313 no 2243 0.329741396958737 3271 1039210 SGTC_335 4077-0256 27.6 µM -0.441691315888789 0.332051525461648 no 2244 0.329356297314447 3228 3121989 SGTC_3063 1327-0034 4 µM -0.443525230430863 0.331367272358415 no 2245 0.328692936957299 3252 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_93 0109-0045 59.227 µM -0.444651562752658 0.330947304421463 no 2246 0.328285789235534 3276 88733 SGTC_2734 clemastine 41.6 µM -0.445071330441066 0.330790842836281 no 2247 0.32813410331922 3209 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3281 9140613 49.47 µM -0.445300900310211 0.330705286898121 no 2248 0.328051158666533 3224 16013766 SGTC_2309 7664088 163.95 µM -0.445558874692525 0.330609155738898 no 2249 0.327957961449707 3354 704922 SGTC_2283 7944793 200 µM -0.445885260801773 0.330487547754836 no 2250 0.327840064793352 3241 2970533 SGTC_2077 5212015 200 µM -0.446402558802312 0.330294844699145 no 2251 0.327653242404075 3170 780900 SGTC_698 k064-0052 127 µM -0.446468333220006 0.330270345737805 no 2252 0.327629491035885 3304 5088751 SGTC_62 0180-0423 3.232 µM -0.447424624448338 0.329914238701547 no 2253 0.327284249817087 3214 30102 YGL099W LSG1 SGTC_115 0527-0192 112.043 µM -0.447825077758757 0.329765162265369 no 2254 0.327139721617802 3293 4233931 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.448000998061245 0.329699681100815 no 2255 0.327076238152267 3217 88881 An O-methylated flavonoid and antioxidant. SGTC_1042 0350-0096 82 µM -0.448766088035932 0.329414959571885 no 2256 0.32680020223636 3183 3122515 SGTC_3229 9132204 49.47 µM -0.448963668092132 0.329341447943228 no 2257 0.326728932949437 3178 17682924 SGTC_2387 9077560 195.08 µM -0.449194402290785 0.329255609335022 no 2258 0.326645712602877 3185 5303272 SGTC_655 k060-0012 42 µM -0.450263468258065 0.328858008884926 no 2259 0.326260238508899 3186 5994525 SGTC_3161 9100388 49.47 µM -0.450622602046233 0.328724485471261 no 2260 0.32613078691919 3218 25236368 SGTC_1810 st050138 53 µM -0.450863062003305 0.328635096370125 no 2261 0.326044123619524 3290 3444541 SGTC_223 busulfan 5 mM -0.450962131284957 0.328598270994133 no 2262 0.32600842115211 3270 2478 A DNA alkylator. SGTC_2602 kawain 100 µM -0.451398419332753 0.328436116707005 no 2263 0.325851211178183 3273 5369129 SGTC_962 1254-0300 21.5 µM -0.451551434264194 0.328379253611632 no 2264 0.32579608183222 3186 7340576 SGTC_948 3448-0295 75.3 µM -0.451779351540472 0.328294562831173 no 2265 0.325713973180491 3248 678569 SGTC_2006 4011487 200 µM -0.452455832035677 0.328043244387491 no 2266 0.325470316567934 3343 45595294 SGTC_2575 plumbagin 510 nM -0.453257543653768 0.327745502264357 no 2267 0.325181650420719 3135 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2732 terfenadine 20 µM -0.454480094207138 0.327291678494777 no 2268 0.324741657983822 3255 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_65 0798-0905 34.986 µM -0.454888090535735 0.32714028267168 no 2269 0.324594875641477 3525 3602145 SGTC_3167 9103034 49.47 µM -0.456875849461711 0.326403089088107 no 2270 0.323880141769519 3297 5127859 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.459607022620835 0.325391293316186 no 2271 0.322899158760953 3374 688751 SGTC_167 3672-0051 66.205 µM -0.459951613891281 0.32526372654004 no 2272 0.322775475748238 3180 3237971 SGTC_2098 5376439 882.5 nM -0.460466970224344 0.325072981199479 no 2273 0.32259053717524 3293 2844116 SGTC_3120 9124077 49.47 µM -0.461054502003137 0.324855577967048 no 2274 0.322379751562493 3271 18774327 YGL155W CDC43 SGTC_1455 4262-0120 131 µM -0.46164240869911 0.324638095697343 no 2275 0.32216888858815 3382 1529587 SGTC_1457 k015-0032 57.3 µM -0.463802796015561 0.323839425059642 no 2276 0.32139451997208 3280 4302660 SGTC_2096 5468907 200 µM -0.465163862046305 0.323336670271356 no 2277 0.320907057872674 3295 759785 SGTC_2385 9074692 200 µM -0.465505969868332 0.323210352094573 no 2278 0.320784581378482 3243 17046906 SGTC_976 1348-1067 47.6 µM -0.468174408585761 0.322225771580183 no 2279 0.319829935767186 3247 5310671 YGL099W LSG1 SGTC_1722 st034304 3.6505 µM -0.468356096811323 0.322158778854135 no 2280 0.319764979289989 3222 4036148 YLR033W RSC58 SGTC_327 1273-0057 3.96 µM -0.468919872666143 0.321950938208986 no 2281 0.319563455502179 3249 3108138 SGTC_2846 9008642 19.48 µM -0.469056842147785 0.321900451678594 no 2282 0.319514503289747 3324 2992898 SGTC_1747 st037496 66.6 µM -0.470388566793281 0.32140975354554 no 2283 0.319038715560985 3215 723305 SGTC_2709 st078560 56 µM -0.47058564237016 0.321337163910866 no 2284 0.31896833129794 3383 17250903 SGTC_158 k038-0087 26.446 µM -0.472120683393901 0.320771989873254 no 2285 0.31842032494843 3171 X158 SGTC_221 trifluoperazine 10.304 µM -0.472798143655383 0.320522693350651 no 2286 0.31817859929982 3307 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2094 5332512 191.667 µM -0.4730013452458 0.320447933597529 no 2287 0.318106109712829 3359 755774 SGTC_1511 0906-3109 28.5 µM -0.474015428735173 0.32007495180647 no 2288 0.317744452493715 3297 2882180 SGTC_257 daunorubicin 18.5 µM -0.474524363076115 0.319887833287644 no 2289 0.317563014401936 3339 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1530 rhein 70.4 µM -0.475814949682463 0.319413532289858 no 2290 0.317103109175168 3305 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1856 st057054 55.7 µM -0.476431701268206 0.319186975337846 no 2291 0.316883427169805 3413 1266018 SGTC_955 1216-0110 33 µM -0.476625716173984 0.319115720038308 no 2292 0.316814333946821 3275 3619719 SGTC_709 3807-1509 243 µM -0.476715057520235 0.3190829101446 no 2293 0.316782519562573 3306 1886677 YPL242C IQG1 SGTC_356 1634-0012 32.5 µM -0.478257489893531 0.31851668784384 no 2294 0.316233474383221 3347 735457 SGTC_3333 9141820 12.094 µM -0.478654340417218 0.318371073665836 no 2295 0.316092276670579 3219 1939433 SGTC_2005 4024620 188 µM -0.482761783422955 0.316865603583254 no 2296 0.314632444465552 3303 236743 SGTC_1933 st074711 15.9 µM -0.48310519917931 0.316739870798882 no 2297 0.314510521317125 3315 17250958 SGTC_2665 lovastatin 100 µM -0.483373822246474 0.316641536173736 no 2298 0.314415165969773 3304 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_727 3032-0951 202 µM -0.483393058331618 0.316634494932944 no 2299 0.314408338052826 3283 3652836 SGTC_1769 st044406 64.4 µM -0.484045462322114 0.31639572615423 no 2300 0.314176802536694 3231 670903 SGTC_1557 sumaresinolic acid 42.3 µM -0.487783549955002 0.315029127207946 no 2301 0.31285158222187 3263 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1916 st067606 49.2 µM -0.488128023135997 0.314903318989191 no 2302 0.312729581461584 3293 19590279 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.488604443203452 0.314729356625652 no 2303 0.312560883377852 3556 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_220 paclitaxel 373.376 µM -0.490470798164383 0.314048262867173 no 2304 0.311900394421094 3330 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2790 5423970 71.43 µM -0.491366695760584 0.313721545300264 no 2305 0.311583557578311 3382 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_148 3253-0744 288.01 µM -0.492043089690223 0.313474973459783 no 2306 0.311344441230585 3366 6893655 SGTC_3041 9091929 49.47 µM -0.492080361825393 0.313461388741348 no 2307 0.311331267231815 3436 25236887 SGTC_1384 3089-0840 101 µM -0.493400476617691 0.3129804047296 no 2308 0.31086482283212 3360 1069836 SGTC_3152 9099253 49.47 µM -0.493910751214642 0.312794571312276 no 2309 0.310684605678596 3318 25236131 SGTC_2792 7535235 81.82 µM -0.49655057670222 0.311833951732571 no 2310 0.309753006521565 3276 1281891 SGTC_277 nystatin 15.5 µM -0.496664432715641 0.311792548805936 no 2311 0.309712853946701 3214 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2043 5101342 149 µM -0.498153276886825 0.311251360322352 no 2312 0.309188005794558 3285 678451 SGTC_1335 1486-0900 202 µM -0.498332493611573 0.311186243281748 no 2313 0.309124854439541 3343 X1335 SGTC_1489 4065-0444 182 µM -0.499264270161909 0.31084778458486 no 2314 0.308796611317411 3363 2877968 SGTC_1689 st020265 53.493 µM -0.499575046336456 0.310734933747669 no 2315 0.308687166067508 3394 5758320 YPR016C TIF6 SGTC_3348 9149464 3.537 µM -0.500186566373075 0.310512927054531 no 2316 0.308471858238758 3338 1951442 SGTC_3113 9123498 49.47 µM -0.500940391607903 0.310239352733939 no 2317 0.30820653731989 3382 8897275 SGTC_125 0133-0007 11.75 µM -0.501742713968639 0.309948293411667 no 2318 0.307924257106072 3423 26541 SGTC_2936 9038235 15.59 µM -0.50267946478482 0.309608618005554 no 2319 0.307594824842553 3308 4749415 SGTC_2128 5255449 168.493 µM -0.504059230499273 0.309108596965495 no 2320 0.30710987762797 3284 736008 SGTC_787 4152-0075 138 µM -0.504842699336141 0.308824828552345 no 2321 0.306834661324527 3307 9566539 SGTC_1617 st002906 78 µM -0.50530842643826 0.308656198627927 no 2322 0.306671112651111 3348 5150859 SGTC_2452 5863136 48.41 µM -0.506602947584632 0.30818769191822 no 2323 0.306216719874451 3291 2184096 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.506979460096767 0.308051484964043 no 2324 0.306084615268284 3373 279621 SGTC_1258 0671-0043 57.1 µM -0.507479196874033 0.307870741297981 no 2325 0.305909314674781 3331 4298767 SGTC_3205 9113483 49.47 µM -0.508149429563784 0.307628406227722 no 2326 0.305674276319503 3411 17018033 SGTC_2821 7996764 71.43 µM -0.508756095465157 0.30740912726014 no 2327 0.305461598682181 3489 2987135 SGTC_692 k241-0027 77.8 µM -0.50907444717344 0.307294086782982 no 2328 0.305350021021201 3444 3600480 SGTC_207 4185-0010 4.486 µM -0.50910057707627 0.307284645248894 no 2329 0.305340863671709 3421 3761753 SGTC_2731 amoxapine 43.43 µM -0.509681359235299 0.307074823848361 no 2330 0.305137357237466 3380 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_523 1934-0222 13.7 µM -0.510971636268892 0.306608906604876 no 2331 0.304685458972332 3288 1361595 SGTC_1460 k062-0059 9.15 µM -0.511387575567866 0.306458778042633 no 2332 0.30453984654271 3286 1373085 SGTC_2070 5230947 200 µM -0.511739926734269 0.306331626302308 no 2333 0.304416519336377 3425 2835538 SGTC_683 panaxydol 45 µM -0.511754727632245 0.306326285663962 no 2334 0.304411339328089 3379 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2852 9023854 51.95 µM -0.512202169670014 0.306164853664667 no 2335 0.304254762391076 3432 19798528 SGTC_3094 9117742 49.47 µM -0.512208736990406 0.306162484530289 no 2336 0.304252464503748 3338 17149698 SGTC_2352 9027995 87.8 µM -0.513797076264029 0.305589735794252 no 2337 0.303696936141125 3320 2997347 SGTC_1038 k292-0204 154 µM -0.516899894425015 0.304472244310713 no 2338 0.302613020666838 3331 4454212 SGTC_3268 9137683 49.47 µM -0.517991513613178 0.304079526503625 no 2339 0.302232095185548 3287 1953228 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.520447744488916 0.303196706497055 no 2340 0.301375770113414 3341 688761 SGTC_736 0958-0254 92.6 µM -0.521666280335599 0.302759165342102 no 2341 0.300951353094114 3430 6812352 SGTC_1699 st031318 29.054 µM -0.522019220419086 0.302632487553052 no 2342 0.300828474129629 3399 5340658 SGTC_1518 st038567 90.8 µM -0.522593752129815 0.302426326578187 no 2343 0.300628494658515 3396 77966 SGTC_344 k064-0035 6.43 µM -0.522640749167478 0.30240946527404 no 2344 0.300612138873756 3271 5088750 SGTC_2549 cedrol 20.94 µM -0.524706166569837 0.301668864515379 no 2345 0.299893734927985 3403 6708665 A sedative which affects the nervous system. SGTC_1792 st045773 43.6 µM -0.524709033298019 0.30166783715407 no 2346 0.299892738348315 3346 2919270 SGTC_1770 st043884 66.3 µM -0.525958398638206 0.301220246753377 no 2347 0.299458555985506 3394 670149 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.527447883003104 0.300687023967717 no 2348 0.298941299644335 3403 140250 A respiratory chain inhibitor. SGTC_2884 9058502 51.95 µM -0.527832549770963 0.300549385771434 no 2349 0.298807781579629 3420 6471554 SGTC_2030 5175110 200 µM -0.528237577062095 0.300404493101954 no 2350 0.298667225662243 3447 2831986 SGTC_328 k915-0120 63.5 µM -0.530939082344485 0.299438876905058 no 2351 0.297730496907982 3408 6624543 SGTC_3341 9147222 25.867 µM -0.532306559883929 0.298950627797902 no 2352 0.297256844797281 3425 1939759 SGTC_1993 st073995 70.8 µM -0.532526974548154 0.298871964003019 no 2353 0.297180532181581 3352 3098394 SGTC_407 eburnamonine 100 µM -0.532816144141531 0.298768776524406 no 2354 0.297080428615235 3334 3195 SGTC_2481 5478948 45.16 µM -0.533123812550167 0.298659005698367 no 2355 0.296973938137229 3443 77792 SGTC_2782 7736369 71.43 µM -0.534262889223218 0.29825276234188 no 2356 0.296579831940024 3359 2950836 YOL077C BRX1 SGTC_120 rhodamine 6G 52.259 µM -0.534849820809224 0.298043535765702 no 2357 0.29637685457455 3321 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2323 6148992 148.28 µM -0.535369954437247 0.29785817692709 no 2358 0.296197031055833 3304 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1802 st050112 57.9 µM -0.535413603613286 0.297842624160545 no 2359 0.296181942694201 3375 4662563 SGTC_785 1270-0111 65.3 µM -0.535501343138381 0.297811362552249 no 2360 0.296151614535933 3384 6741994 SGTC_25 0118-0223 35.662 µM -0.535923164993784 0.2976610882473 no 2361 0.296005826940992 3464 5333628 SGTC_574 1315-0397 40 µM -0.536669964744529 0.297395125254971 no 2362 0.295747803219258 3406 6794277 SGTC_2981 9013952 38.96 µM -0.53834426242561 0.296799240808951 no 2363 0.295169699384982 3365 2996344 SGTC_464 bw-b 70c 158 µM -0.538985316659791 0.296571233655976 no 2364 0.294948493109605 3444 5353454 SGTC_2978 9011784 42.97 µM -0.539680969561684 0.296323897933244 no 2365 0.294708533128359 3385 2994934 SGTC_1695 st026914 34.495 µM -0.541205784658548 0.295782089107394 no 2366 0.294182875391789 3387 3289191 SGTC_2708 st078559 56 µM -0.541948633962637 0.295518299254524 no 2367 0.293926945968295 3398 17250902 SGTC_1056 3448-1962 115 µM -0.542176126123158 0.295437537186936 no 2368 0.293848590055538 3403 715507 SGTC_2506 ethyl hematommate 54.16 µM -0.544032335934214 0.294778943237034 no 2369 0.293209610656549 3396 3940691 An allergen. SGTC_1060 3448-7350 82 µM -0.545498896346246 0.294259078310847 no 2370 0.292705219688411 3441 570178 SGTC_557 1315-0110 16.2 µM -0.548019122098088 0.293366701688575 no 2371 0.291839386441286 3416 6833801 SGTC_92 0063-0024 660.874 µM -0.54941094015546 0.292874416509888 no 2372 0.291361733958734 3452 3594437 SGTC_729 4092-0585 94.1 µM -0.549630302262071 0.292796863261893 no 2373 0.291286485243662 3347 2169061 SGTC_730 1436-0052 41.2 µM -0.549930345533698 0.292690801449006 no 2374 0.291183574817092 3450 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2238 6671620 73.2395 µM -0.552802213849193 0.291676533342347 no 2375 0.290199426200872 3411 729941 SGTC_1516 st013856 110 µM -0.554147590725385 0.291201945908956 no 2376 0.289738921235188 3420 5281404 A mutagen and neurotoxin. SGTC_606 k015-0008 38.6 µM -0.555702612774665 0.29065385485119 no 2377 0.289207085077889 3485 1970475 SGTC_1082 camptothecin 424.86 nM -0.557163826477578 0.290139268151862 no 2378 0.28870775112601 3272 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2661 dactinomycin 12.96 µM -0.55762019123754 0.289978640497012 no 2379 0.288551882901282 3414 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.558425762856511 0.289695203579586 no 2380 0.288276842297241 3586 5282309 SGTC_2692 st077426 47.7 µM -0.558521883939563 0.289661392473537 no 2381 0.288244032615747 3474 25238571 SGTC_3204 9114183 49.47 µM -0.559010524142823 0.289489539311756 no 2382 0.288077268878689 3384 17027248 SGTC_1439 4092-1168 46 µM -0.559838367815667 0.289198498732955 no 2383 0.287794845319383 3426 2886240 SGTC_1103 duloxetine 36.1 µM -0.559962386221444 0.289154910094404 no 2384 0.287752547004899 3504 60835 A selective serotonin reuptake inhibitor. SGTC_2519 cryptotanshinone 88.04 µM -0.560147174279456 0.289089968531332 no 2385 0.287689527749348 3474 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_543 3844-1095 191 µM -0.560969016616211 0.288801224952218 no 2386 0.287409329515547 3434 4230703 SGTC_3198 9112019 49.47 µM -0.561098833185105 0.288755628014356 no 2387 0.287365081771887 3446 45595555 SGTC_806 3966-4455 5.86 µM -0.563136527002497 0.288040350397953 no 2388 0.286670960165146 3370 714982 SGTC_2683 piperine 63.03 µM -0.563603253608181 0.28787663636 no 2389 0.286512086027219 3389 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2711 st079103 59.1 µM -0.564910813103336 0.287418216901061 no 2390 0.286067214242562 3397 54693780 SGTC_2645 abamectin 100 µM -0.566284338414956 0.286937042545999 no 2391 0.285600252637381 3451 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1883 5-benzylidenerhodanine 20 µM -0.566871785625145 0.286731364206119 no 2392 0.285400647222169 3448 1273210 SGTC_2137 5261020 140 µM -0.567337429380761 0.286568381641833 no 2393 0.285242475939783 3431 763655 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.568324063601673 0.286223189581001 no 2394 0.284907471114725 3417 5106787 A p450 inhibitor. SGTC_2870 9038528 12.99 µM -0.56834985240718 0.286214169543674 no 2395 0.284898717221682 3466 6463316 SGTC_1662 st014054 52 µM -0.568486879671126 0.286166244383404 no 2396 0.284852206090706 3461 2838777 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.568590527356745 0.286129996232371 no 2397 0.284817027388532 3483 165521 SGTC_1013 4112-3890 241 µM -0.568814055801567 0.28605183024952 no 2398 0.284741167429743 3328 705171 SGTC_2779 methotrexate 400 µM -0.570021103260141 0.285629911522008 no 2399 0.284331692460766 3514 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2918 7977171 22.06 µM -0.570221079028419 0.285560039377867 no 2400 0.28426388049694 3432 2236483 SGTC_1018 4259-0013 28.1 µM -0.570256050804028 0.285547820968485 no 2401 0.2842520223305 3466 6801262 SGTC_1740 st038286 13.222 µM -0.571367914295842 0.285159488824252 no 2402 0.283875136999088 3506 716786 SGTC_2984 9022109 38.96 µM -0.572273256504992 0.284843472838103 no 2403 0.28356843240296 3539 6459207 SGTC_411 enrofloxacin 100 µM -0.574057317063113 0.284221223625447 no 2404 0.282964507768687 3550 71188 A bacterial gyrase inhibitor. SGTC_2369 9071472 200 µM -0.574981147128961 0.28389926340936 no 2405 0.282652023723568 3477 17296037 SGTC_1305 1181-0477 144 µM -0.575985805246282 0.283549332398403 no 2406 0.282312388080883 3501 6252086 SGTC_2822 7994718 71.43 µM -0.576663893250935 0.283313265433297 no 2407 0.282083264074871 3452 1018011 SGTC_2434 5670830 169.91 µM -0.577163293290546 0.283139466501802 no 2408 0.281914575498776 3457 1549830 SGTC_2900 5328528 85.29 µM -0.577931608952854 0.282872180716025 no 2409 0.281655146881044 3493 795359 SGTC_2914 7968218 45.32 µM -0.579595877688624 0.282293621837985 no 2410 0.281093586803632 3448 2977111 SGTC_2339 9000433 200 µM -0.582204768000215 0.28138782648423 no 2411 0.280214381066655 3408 2988954 SGTC_3023 9089636 49.47 µM -0.585167692008908 0.280360816333609 no 2412 0.279217483205453 3566 17249241 SGTC_1621 st003705 32.4 µM -0.585876922110648 0.280115252161367 no 2413 0.278979113396963 3523 24207032 SGTC_2826 7992541 19.48 µM -0.588335761051168 0.279264710607376 no 2414 0.278153473337104 3552 2985066 SGTC_573 3702-0553 84.7 µM -0.588940953648986 0.279055559938533 no 2415 0.277950441936507 3496 1222756 SGTC_2582 agaric acid 100 µM -0.58917085641484 0.278976126991001 no 2416 0.277873332590068 3483 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2246 7293507 91.5585 µM -0.589657877564196 0.278807894252741 no 2417 0.277710020282935 3504 887656 SGTC_1812 st052057 4.327 µM -0.590709354020726 0.278444848992966 no 2418 0.277357589694322 3470 3645418 SGTC_3228 9131799 49.47 µM -0.591395254589693 0.278208151010984 no 2419 0.277127809605759 3460 17015818 SGTC_505 gw-5074 63.9 µM -0.591600618212926 0.278137301002952 no 2420 0.277059029899036 3488 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2486 5283202 22.39 µM -0.591808175930854 0.278065702979938 no 2421 0.276989523843517 3432 1377751 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.592131771661809 0.277954095031753 no 2422 0.276881176497649 3490 91467 include heat shock SGTC_86 0417-1630 471.922 µM -0.59283949992425 0.277710076252944 no 2423 0.276644285040658 3535 3634867 SGTC_2888 9058547 12.99 µM -0.592995600831282 0.277656268054689 no 2424 0.27659204817452 3442 16476514 SGTC_926 2268-1401 59.4 µM -0.593093055477911 0.277622677885843 no 2425 0.27655943886597 3515 2931578 SGTC_1635 st007035 42.4 µM -0.593721069422579 0.277406264884332 no 2426 0.276349344276286 3525 3716403 SGTC_702 1488-0190 94 µM -0.595187371891635 0.276901299774894 no 2427 0.275859115250001 3508 949357 SGTC_907 3448-6986 75.5 µM -0.597820033250488 0.275995795201209 no 2428 0.274980011006262 3563 590582 SGTC_2286 7945697 125 µM -0.599616083341347 0.275378878872427 no 2429 0.274381062958577 3477 1245733 SGTC_1658 st012944 20 µM -0.600524203864475 0.27506721154417 no 2430 0.274078467600624 3491 24207260 SGTC_318 1488-0629 67.2 µM -0.603321129977969 0.27410839834932 no 2431 0.27314753946202 3527 3662576 SGTC_1382 3002-2117 298 µM -0.604138266919554 0.273828587933068 no 2432 0.272875859878351 3583 1497314 SGTC_1937 st074714 47.2 µM -0.604221462395694 0.273800107412061 no 2433 0.272848206779794 3419 17250970 SGTC_2279 7948423 32.93 µM -0.604563055683928 0.273683184261895 no 2434 0.272734680167838 3566 1247112 SGTC_329 k048-0121 21.3 µM -0.607557187678704 0.272659388346573 no 2435 0.27174060140145 3525 6832902 SGTC_2923 7992654 58.14 µM -0.608312447652252 0.272401439706515 no 2436 0.271490133416854 3520 2985126 SGTC_396 dithiazanine 1.25 µM -0.609003041282778 0.272165683099933 no 2437 0.271261211518274 3458 10578 An antihelmenthic. SGTC_3199 9111318 49.47 µM -0.609823883342845 0.271885593935214 no 2438 0.270989239338452 3487 8548020 SGTC_860 0443-0016 25.1 µM -0.610541583267798 0.271640816670826 no 2439 0.270751553090232 3535 5337942 SGTC_972 1319-0219 195 µM -0.612335583223896 0.271029439026696 no 2440 0.270157875834943 3485 23903702 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.612390824490919 0.271010624241752 no 2441 0.270139605524084 3594 688801 SGTC_309 k408-0051 1.48 µM -0.613173808142319 0.270744015633254 no 2442 0.269880710625185 3520 3640463 SGTC_2759 disulfiram 3.38 µM -0.615683465672394 0.269890352142646 no 2443 0.269051725999684 3497 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_97 0535-0701 19.132 µM -0.617890805745858 0.2691406376895 no 2444 0.2683236600469 3529 2832013 YGL099W LSG1 SGTC_2405 ticlatone 3.52 µM -0.61842434849759 0.268959578909673 no 2445 0.26814782588896 3420 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_497 capsazepine 133 µM -0.619668349910487 0.268537662220399 no 2446 0.267738078582141 3481 2733484 A calcium channel blocker. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.620770806961604 0.268164030120921 no 2447 0.267375216826398 3556 3256 An antibiotic and ribosome inhibitor. SGTC_259 usnic acid 108.925 µM -0.62452031731975 0.266895250138564 no 2448 0.266142965774329 3625 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1964 st076914 61 µM -0.625511890209824 0.266560224005319 no 2449 0.265817573537541 3575 24208661 SGTC_2047 4141938 200 µM -0.625866814577503 0.266440356199123 no 2450 0.265701151412054 3520 3807862 SGTC_443 clozapine 122 µM -0.626506931650424 0.266224239864336 no 2451 0.265491245888332 3488 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.626889098447656 0.266095255023095 no 2452 0.265365966867379 3551 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2693 st077581 40.7 µM -0.627117235208872 0.266018271836399 no 2453 0.265291195108477 3564 25238761 SGTC_2529 gangaleoidin 93.61 µM -0.627295594669167 0.265958093517465 no 2454 0.265232745296193 3587 4565183 SGTC_1465 k213-0056 144 µM -0.627615035299993 0.26585033178091 no 2455 0.265128078407804 3483 24048857 YMR208W ERG12 SGTC_3122 9126309 49.47 µM -0.630285442777804 0.264950349399 no 2456 0.264253922766782 3595 17591206 SGTC_32 0928-0142 34.1 µM -0.630329470887823 0.264935524002076 no 2457 0.264239522510329 3544 2244242 SGTC_1280 0880-0253 10.1 µM -0.630781148298574 0.264783456952343 no 2458 0.264091815641394 3530 6836607 SGTC_193 1273-0060 1.558 µM -0.630809607948874 0.264773876876828 no 2459 0.264082510218218 3481 2847393 YHR072W ERG7 SGTC_1483 3453-0561 55.9 µM -0.632453221065621 0.264220903669237 no 2460 0.263545383256298 3579 4546991 SGTC_2470 5664817 21.68 µM -0.633356421020912 0.263917283868154 no 2461 0.263250458236603 3594 2859561 SGTC_3083 9117465 49.47 µM -0.634869827878528 0.263408935812281 no 2462 0.262756658389168 3570 16420915 SGTC_832 4083-0019 164 µM -0.636209616813443 0.262959322925627 no 2463 0.26231990294149 3651 1990758 SGTC_3156 9099931 49.47 µM -0.637199312307755 0.26262744821949 no 2464 0.261997512787883 3561 18111053 SGTC_1871 st057448 67.3 µM -0.637223965876249 0.262619183872288 no 2465 0.261989484560239 3663 691747 SGTC_199 4063-0024 41.6 µM -0.637537445129089 0.262514111242644 no 2466 0.261887413671326 3595 306215 SGTC_563 tetrahydrosecaminediol 614 µM -0.637587503261007 0.262497334646302 no 2467 0.261871116305631 3624 334274 A psychoactive constituent of the cannabis plant. SGTC_3181 9108277 49.47 µM -0.637686514154023 0.262464153526526 no 2468 0.26183888298036 3527 17097298 SGTC_2833 9001315 45.46 µM -0.63981773736802 0.261750446247777 no 2469 0.261145549851984 3513 2989378 SGTC_1372 2752-0194 270 µM -0.641240091496644 0.261274680729156 no 2470 0.260683352768877 3558 823334 SGTC_1144 3486-0183 12.5 µM -0.642183022820209 0.260959523185769 no 2471 0.260377177400801 3580 6744069 SGTC_1286 0929-0070 131 µM -0.643992036972417 0.260355441052615 no 2472 0.259790298844386 3637 1420408 SGTC_1680 diphenhydramine 100 µM -0.64758569237287 0.259157556080594 no 2473 0.258626476833387 3554 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2424 5537928 59.2 µM -0.648337223261268 0.258907406524647 no 2474 0.258383431802513 3614 5382802 SGTC_2965 9082772 38.63 µM -0.648992664112026 0.25868934287839 no 2475 0.258171558934487 3628 16459634 SGTC_1265 0819-1001 68.8 µM -0.649236698559786 0.258608177481185 no 2476 0.258092697215571 3609 3106768 SGTC_3282 9108498 15.4605 µM -0.649532712466106 0.258509741515001 no 2477 0.257997054680289 3557 16459645 SGTC_2557 derrustone 83.84 µM -0.649681169481418 0.258460381176809 no 2478 0.257949094919877 3603 629853 An antioxidant. SGTC_1067 clotrimazole 1.36 µM -0.650754483118573 0.258103661399047 no 2479 0.25760249337743 3613 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1065 prochlorperazine maleate 2.48 µM -0.650771725056055 0.258097933061242 no 2480 0.25759692747129 3635 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2411 st077133 39.94 µM -0.651421745172014 0.257882023136156 no 2481 0.257387138676096 3689 1403142 YNL221C POP1 SGTC_2248 tofa 1.1 µM -0.654683982512263 0.256799859286388 no 2482 0.256335620027045 3554 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3311 9131146 2.8755 µM -0.654827449590027 0.256752322069677 no 2483 0.256289427661888 3583 4900406 YPR165W RHO1 SGTC_548 1436-0017 110 µM -0.655744505925717 0.256448567546755 no 2484 0.255994263850335 3652 9677137 SGTC_191 3914-0123 66.505 µM -0.65591167454758 0.256393216840651 no 2485 0.255940478063937 3512 3144412 SGTC_3185 9108267 49.47 µM -0.658389273144639 0.25557359699032 no 2486 0.255144013203229 3592 4910486 SGTC_1403 3909-7815 62.9 µM -0.658505484816966 0.25553518638095 no 2487 0.255106686899172 3558 6615483 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.660025764551539 0.255032977150674 no 2488 0.254618647829615 3652 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2174 5790901 200 µM -0.660440692358475 0.254895999642168 no 2489 0.254485533011396 3607 786020 SGTC_1186 1319-0216 26 µM -0.661682145401761 0.254486396606442 no 2490 0.254087474856459 3667 4565136 SGTC_420 mitomycin C 81.9 mM -0.663983901803023 0.253727872249306 no 2491 0.253350307239579 3608 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.664262248340438 0.253636226029903 no 2492 0.253261239374294 3579 390807 SGTC_275 trichlorophene 5.69 µM -0.664415393949823 0.253585809911425 no 2493 0.253212241466665 3642 62616 SGTC_375 3970-0961 9.27 µM -0.665748485688961 0.253147173482041 no 2494 0.252785938376933 3578 2898222 SGTC_1709 st033179 39.1045 µM -0.66610224526468 0.253030840548807 no 2495 0.252672874755086 3603 573381 SGTC_24 0417-1663 219 µM -0.666312454092925 0.252961727237281 no 2496 0.252605703405834 3604 4329390 SGTC_589 1227-0070 34.1 µM -0.667947199221222 0.252424588310645 no 2497 0.252083648644817 3628 2841384 SGTC_489 paxilline 115 µM -0.669386995666117 0.251952003287586 no 2498 0.25162432245985 3617 105008 A toxic potassium channel blocker. SGTC_2291 7917025 104.35 µM -0.669895332608554 0.251785263225982 no 2499 0.251462257649887 3591 2964612 SGTC_1762 st045503 25.4615 µM -0.671881843925512 0.251134224964975 no 2500 0.250829459875339 3649 4645554 SGTC_775 4577-0580 57.3 µM -0.672446393309912 0.250949368122738 no 2501 0.250649778162882 3686 2006902 SGTC_1212 0520-0165 585 µM -0.673064828911842 0.250746949382413 no 2502 0.250453024113472 3762 5403258 SGTC_599 1935-0052 86.5 µM -0.67341660336529 0.250631849479276 no 2503 0.250341144306165 3616 9557311 SGTC_1766 st045414 44.774 µM -0.673475811007322 0.250612479608249 no 2504 0.250322316267226 3675 253960 SGTC_1419 3993-2473 62.6 µM -0.673923270628 0.250466118152228 no 2505 0.250180048320672 3664 704026 SGTC_333 3486-0131 40.1 µM -0.674070904004214 0.250417838068225 no 2506 0.250133118306014 3698 6744690 SGTC_3067 9117431 49.47 µM -0.674720908138608 0.250205327918033 no 2507 0.249926549148074 3631 17150885 SGTC_2446 5162541 200 µM -0.67530338380895 0.250014976578069 no 2508 0.249741517260145 3606 1549321 SGTC_3232 9132874 49.47 µM -0.675493506201538 0.249952861775984 no 2509 0.24968113786103 3610 3784940 SGTC_1324 1418-0026 34.4 µM -0.675706290679455 0.249883352767618 no 2510 0.249613570592863 3661 1372513 SGTC_206 4546-0025 72.014 µM -0.676131252607789 0.249744563758343 no 2511 0.249478657885887 3650 6620745 YIL048W NEO1 SGTC_1853 st056710 91.2 µM -0.676390505907301 0.24965991390781 no 2512 0.249396371748701 3708 269167 SGTC_104 0074-0074 590.992 µM -0.678509039949407 0.248968754186334 no 2513 0.248724497020286 3508 3943124 SGTC_2151 5563267 85.4165 µM -0.678709193902888 0.248903507778777 no 2514 0.248661069798377 3645 5310824 SGTC_3017 9080681 49.47 µM -0.679167212232784 0.248754236703942 no 2515 0.248515959791164 3640 16451914 SGTC_1438 4092-1045 4 µM -0.68026951747857 0.24839518393766 no 2516 0.248166910950956 3637 1351342 SGTC_699 0375-0592 111 µM -0.680302695966632 0.248384381026462 no 2517 0.248156408920773 3679 762578 SGTC_1826 st055655 41.6 µM -0.680977784799691 0.248164626591918 no 2518 0.247942773659371 3672 676168 SGTC_527 4476-4215 268 µM -0.681153952777063 0.248107297583091 no 2519 0.247887040568362 3625 4418754 SGTC_55 0767-0285 6.563 µM -0.681923556249688 0.247856934226334 no 2520 0.247643644670186 3621 3116166 SGTC_2857 9024691 58.44 µM -0.683488802826879 0.247348152780518 no 2521 0.24714901160938 3671 16478292 SGTC_289 k017-0060 526 µM -0.684189133526988 0.247120692064165 no 2522 0.246927871552809 3631 5512909 SGTC_1263 0774-1208 64.8 µM -0.684532697815757 0.247009146587338 no 2523 0.246819424638428 3687 906585 SGTC_1252 0493-0875 34.8 µM -0.685153784189875 0.246807566032658 no 2524 0.246623441919442 3655 3960963 SGTC_3000 9075062 71.4286 µM -0.685584223891804 0.246667913679379 no 2525 0.246487666339439 3635 17057871 SGTC_1374 2889-5571 141 µM -0.685782499748721 0.246603599071082 no 2526 0.24642513674802 3649 2853281 SGTC_1646 st011709 75.6 µM -0.68659406493301 0.24634044586044 no 2527 0.246169284791522 3629 5757843 SGTC_1448 4255-0083 152 µM -0.68792431124601 0.245909434021815 no 2528 0.24575022306242 3688 5399660 SGTC_3307 9126885 69.2785 µM -0.688039959868861 0.245871981952867 no 2529 0.245713808883201 3654 24824909 SGTC_159 3970-0959 50 µM -0.688364369092936 0.245766940435121 no 2530 0.24561167790281 3734 6615653 SGTC_50 0929-0078 56.389 µM -0.688904316998562 0.245592162380901 no 2531 0.245441741291131 3570 1377751 SGTC_2755 lomerizine 42.69 µM -0.689670240819553 0.245344351776542 no 2532 0.245200792194972 3662 3949 A calcium channel blocker. SGTC_38 0929-0051 58.268 µM -0.690621530978016 0.245036754093961 no 2533 0.244901706571076 3667 1379719 SGTC_584 0986-0246 15.4 µM -0.69085293272444 0.24496196220496 no 2534 0.244828983559245 3745 53315 YDR232W HEM1 SGTC_1848 st056003 16.4 µM -0.691281735788454 0.24482340025898 no 2535 0.244694253638456 3703 146492 SGTC_1120 ficusin 1.78878 µM -0.691676123271746 0.244695996498271 no 2536 0.244570372345208 3711 6199 A DNA cross-linker. SGTC_427 1354-0053 47.3 µM -0.692110232288117 0.244555802292858 no 2537 0.244434053162138 3709 6813657 SGTC_1184 1269-1718 139 µM -0.694129453298273 0.243904269955166 no 2538 0.243800514582075 3682 5403821 SGTC_3246 9135460 32.98 µM -0.694199821770717 0.24388158139968 no 2539 0.243778452188234 3596 41446951 SGTC_3054 9094397 49.47 µM -0.695949346762164 0.24331785711661 no 2540 0.243230276048243 3668 2598354 SGTC_1371 2421-0008 32.7 µM -0.697604735674906 0.242785114029 no 2541 0.24271220958665 3656 2827552 SGTC_2580 diallyl disulphide 81.36 µM -0.699163762864997 0.242283960232496 no 2542 0.24222484696707 3686 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1636 st007707 68.9 µM -0.699510575151956 0.242172552700112 no 2543 0.242116503232544 3686 403051 SGTC_966 1300-0360 30.2 µM -0.700215372885558 0.241946234040061 no 2544 0.241896406262099 3671 70588 SGTC_2032 5185112 25.99 µM -0.702340522732924 0.241264519040885 no 2545 0.241233413822766 3608 5718189 SGTC_2694 st077685 81.9 µM -0.702936139068075 0.241073642039157 no 2546 0.241047774090139 3657 2838096 SGTC_202 3594-0513 34.79 µM -0.702957197948946 0.241066894808632 no 2547 0.241041211949788 3657 708429 SGTC_340 k038-0059 454 µM -0.703048535439067 0.241037631616693 no 2548 0.241012751474854 3679 23733424 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.703234515401045 0.240978052336502 no 2549 0.240954806352271 3674 521171 SGTC_1978 st071761 42 µM -0.703891492021338 0.240767651892303 no 2550 0.240750175130712 3681 5147680 SGTC_2583 asiatic acid 100 µM -0.70435613307651 0.240618908362043 no 2551 0.240605508575689 3697 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_268 camptothecin 39.6153 µM -0.70465596057123 0.240522952445095 no 2552 0.240512182050114 3689 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3252 9135871 49.47 µM -0.70601111817828 0.240089511790665 no 2553 0.240090611657221 3704 17682838 SGTC_3349 9149703 23.001 µM -0.709646018831823 0.238929011999654 no 2554 0.23896183738292 3682 4910494 SGTC_544 k015-0020 52.4 µM -0.710251936368554 0.238735861912178 no 2555 0.238773959614647 3696 3008304 SGTC_2232 chlorophetanol 41.5365 µM -0.710442871820897 0.238675014571181 no 2556 0.238714772718183 3753 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2987 9018338 71.43 µM -0.710637757793624 0.23861291703005 no 2557 0.238654369503376 3749 5055682 SGTC_3206 9114350 49.47 µM -0.71090975059925 0.238526265317587 no 2558 0.238570081679507 3636 17087243 SGTC_1750 st081859 2.357 µM -0.710983026762039 0.238502923877582 no 2559 0.238547376923048 3694 5291695 SGTC_1490 4089-0339 670 nM -0.711095779977835 0.238467009832104 no 2560 0.238512442438077 3652 742542 SGTC_2012 4023501 200 µM -0.711832860584711 0.238232308586638 no 2561 0.238284140743997 3687 3477460 SGTC_2086 5274770 176.623 µM -0.712795229131416 0.237926061716387 no 2562 0.237986239129137 3725 689278 SGTC_1136 pergolide 1.05886 µM -0.714303579657018 0.237446505930701 no 2563 0.237519739600623 3692 47811 A dopamine receptor agonist. SGTC_2244 6635614 200 µM -0.715108749454119 0.237190732534698 no 2564 0.237270923969237 3620 836499 SGTC_944 3370-0224 231 µM -0.717816788617729 0.236331597783951 no 2565 0.236435130142031 3733 4580514 SGTC_2132 5317594 122.667 µM -0.718804171302887 0.2360187739933 no 2566 0.236130793591185 3687 794577 SGTC_2185 6113692 200 µM -0.719029428639528 0.235947439665807 no 2567 0.236061393772827 3689 874150 SGTC_313 3474-0040 5.03 µM -0.721792903560077 0.235073272235821 no 2568 0.235210906552543 3697 1043375 YIL048W NEO1 SGTC_3164 9100705 49.47 µM -0.724984816671557 0.234065807859754 no 2569 0.234230672590019 3692 17174235 SGTC_176 1486-1328 72.834 µM -0.725629274294826 0.233862688069383 no 2570 0.234033034926428 3762 22310231 SGTC_1612 st002233 45.4 µM -0.725954098595705 0.233760347162719 no 2571 0.233933455149396 3736 1035021 SGTC_947 3447-0010 211 µM -0.726642685848391 0.233543479237463 no 2572 0.233722436013884 3710 748350 SGTC_2838 9002687 71.43 µM -0.726643233617301 0.233543306764165 no 2573 0.233722268190864 3712 6457060 SGTC_3100 9120536 49.47 µM -0.727467721879699 0.233283784292492 no 2574 0.233469740849507 3597 16421196 SGTC_760 0568-0725 82.9 µM -0.727858425176067 0.233160859333189 no 2575 0.233350127658442 3756 3916171 SGTC_2364 9055074 200 µM -0.728063468397243 0.233096362033951 no 2576 0.233287367610744 3731 6470630 SGTC_2122 5258151 111.688 µM -0.728538663255695 0.232946925368198 no 2577 0.23314195501503 3727 2173356 SGTC_2255 7941087 197.44 µM -0.728990321318203 0.232804939762841 no 2578 0.233003791480709 3725 935561 SGTC_2635 hydroquinidine 100 µM -0.729415222598465 0.23267140947017 no 2579 0.232873854446334 3688 442912 An experimental heart treatment. SGTC_2320 7373003 200 µM -0.729586673633773 0.232617540995301 no 2580 0.232821435223763 3755 5415828 SGTC_1767 st044992 70.3 µM -0.730201577063926 0.232424400537427 no 2581 0.232633489357932 3739 9600693 SGTC_1111 tnp00062 510.699 nM -0.730970685977867 0.232182949913066 no 2582 0.232398529190942 3787 676306 SGTC_1281 0884-0031 11.8 µM -0.731415254180136 0.232043447842963 no 2583 0.23226277533511 3739 1548255 SGTC_3073 9114972 49.47 µM -0.733148589248036 0.23149998656838 no 2584 0.231733903767563 3647 41905075 SGTC_2656 pseudo-anisatin 100 µM -0.733239098501361 0.231471628253725 no 2585 0.231706306218893 3775 6708809 A neurotoxin. SGTC_2570 licareol 100 µM -0.73422659813422 0.231162351231026 no 2586 0.231405322664504 3739 443158 SGTC_2912 7964298 10.93 µM -0.734763722816736 0.230994224922915 no 2587 0.231241702095792 3787 2975850 SGTC_477 mead ethanolamide 10 µM -0.735898856861866 0.230639139352443 no 2588 0.230896126502351 3611 16061185 SGTC_1765 st044815 90.4 µM -0.736161589005634 0.230556996602559 no 2589 0.230816182511959 3753 645695 SGTC_983 1491-0821 12.2 µM -0.736987414410113 0.230298910208579 no 2590 0.23056500150262 3711 46495113 SGTC_889 0919-1524 82.7 µM -0.737362458142699 0.230181755163808 no 2591 0.230450979588371 3773 3905452 SGTC_817 1391-0715 46 µM -0.73812530736867 0.229943561494567 no 2592 0.230219153182188 3725 1353946 SGTC_1307 1187-1599 12.2 µM -0.738540994078324 0.229813824683819 no 2593 0.230092882810185 3741 1538471 SGTC_901 1112-0062 60.1 µM -0.738818767250575 0.229727153865099 no 2594 0.230008527114108 3739 1908457 SGTC_899 1083-0020 478 µM -0.738982376956111 0.229676112912616 no 2595 0.229958849312492 3772 767123 SGTC_1594 piperine 70.1 µM -0.739508833605598 0.229511918523446 no 2596 0.229799038863342 3725 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2263 7948595 193.29 µM -0.741011248401234 0.229043698461002 no 2597 0.229343310053868 3730 2971371 SGTC_352 k048-0007 5.11 µM -0.741494417166163 0.228893235285572 no 2598 0.229196857782338 3754 6811911 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.742155457650752 0.22868747112053 no 2599 0.228996576172535 3736 688667 SGTC_2484 5809818 12.04 µM -0.74272899954757 0.228509027101311 no 2600 0.228822884415359 3748 2870548 SGTC_2269 7935389 174.42 µM -0.742892561970976 0.228458152852832 no 2601 0.228773364632161 3717 97605 SGTC_3053 9095903 49.47 µM -0.743381669605655 0.22830605940813 no 2602 0.228625319429137 3806 17174018 SGTC_2208 7283366 200 µM -0.745703092313077 0.227584963839708 no 2603 0.227923395383642 3725 898663 SGTC_933 2914-0560 114 µM -0.746326380633607 0.227391572541051 no 2604 0.227735139584523 3765 463887 SGTC_937 3122-0005 46.7 µM -0.747139933841811 0.227139285985584 no 2605 0.227489548576928 3768 759535 SGTC_58 0957-0393 9 µM -0.747639550871212 0.226984430704648 no 2606 0.227338800871801 3675 6997992 SGTC_2358 9037157 4 µM -0.748738766319487 0.226643940787693 no 2607 0.22700733663807 3778 2388925 SGTC_1444 4112-3581 28 µM -0.749114871117091 0.226527505837989 no 2608 0.226893986273202 3784 2877249 SGTC_2526 patulin 37.61 µM -0.749674648767853 0.226354271790293 no 2609 0.226725339764369 3811 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2219 9098279 200 µM -0.750251805156419 0.226175737927984 no 2610 0.226551531579213 3724 902349 SGTC_3201 9113999 49.47 µM -0.75178866019073 0.225700725276693 no 2611 0.226089081251919 3789 16649224 SGTC_1449 4112-4002 201 µM -0.752944056879339 0.225343986100849 no 2612 0.22574176599417 3768 2059539 SGTC_1329 1447-1697 50.6 µM -0.754417657577917 0.224889462190853 no 2613 0.225299236042301 3788 2840515 SGTC_807 1315-0151 48 µM -0.754887527922511 0.224744642656604 no 2614 0.225158234900384 3763 4011080 SGTC_2028 5153890 36.43 µM -0.755175338953821 0.224655962055989 no 2615 0.225071891760492 3728 2830968 YPR165W RHO1 SGTC_1380 2291-0730 164 µM -0.755287248133733 0.224621485855992 no 2616 0.225038324138812 3795 2999191 SGTC_2685 mycophenolic acid 18.85 µM -0.755762055706857 0.224475243833552 no 2617 0.22489593519906 3754 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_27 0485-0001 32.618 µM -0.756655612349088 0.224200172531519 no 2618 0.224628107120041 3691 2054479 SGTC_1743 st037606 46.3785 µM -0.757465357274616 0.223951067122622 no 2619 0.224385556493551 3784 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3135 9127742 49.47 µM -0.75785303818241 0.223831858825717 no 2620 0.224269483374074 3833 3643468 SGTC_2968 9090663 33.37 µM -0.758460823871042 0.223645042954604 no 2621 0.224087578691413 3767 25236811 SGTC_971 1315-0384 26.7 µM -0.758551472661662 0.223617187718829 no 2622 0.224060455523313 3788 6769120 SGTC_1941 st076221 61.8 µM -0.758553431622827 0.223616585776427 no 2623 0.224059869400029 3737 2828568 SGTC_1174 0739-0097 51.1 µM -0.75863009044986 0.223593031056755 no 2624 0.224036933680602 3783 728447 SGTC_1289 0976-0073 69.1 µM -0.759130865177359 0.223439194282209 no 2625 0.223887138630551 3812 3391136 SGTC_748 act1.228 77.9 µM -0.760298866303186 0.223080621299664 no 2626 0.223537979691451 3714 4421505 YNR035C ARC35 SGTC_616 4092-0450 108 µM -0.760564068766401 0.222999250576975 no 2627 0.22345874398759 3819 787165 SGTC_1155 4088-0394 48.2 µM -0.763865470490468 0.221987714350795 no 2628 0.222473708152694 3757 2326248 SGTC_1568 digitonin 820 nM -0.763891587038938 0.22197972280352 no 2629 0.222465925669858 3769 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3111 9122088 49.47 µM -0.764839252281925 0.221689852612272 no 2630 0.222183635496755 3676 16876704 SGTC_2623 humulene 100 µM -0.765341919237034 0.22153618554934 no 2631 0.222033984260694 3717 6187145 An anti-inflammatory. SGTC_3249 9135183 49.47 µM -0.76596776573086 0.221344947185732 no 2632 0.221847741141131 3778 4902779 SGTC_2026 5148700 152 µM -0.766401328555547 0.221212519839254 no 2633 0.22171877127342 3774 79838 SGTC_435 c-PAF 6.7 µM -0.768293177344885 0.220635204543806 no 2634 0.221156513549917 3805 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1401 3807-4679 7.6 µM -0.768827687851322 0.220472250192277 no 2635 0.220997804876415 3758 3291456 SGTC_2931 9014674 55.67 µM -0.773209442792756 0.219139002748176 no 2636 0.219699219312938 3808 2996810 SGTC_1728 st035614 33.7865 µM -0.773275997804779 0.219118787693775 no 2637 0.219679528775867 3798 15945546 SGTC_1048 3161-0300 24.5 µM -0.773465574108593 0.219061212703871 no 2638 0.21962344750624 3789 2165101 SGTC_1731 st035964 63 µM -0.775072028221222 0.218573676275646 no 2639 0.219148549550905 3791 6739575 SGTC_2707 st078556 66.6 µM -0.775133214249102 0.218555119527319 no 2640 0.219130473493075 3782 17250899 SGTC_2951 9072950 58.06 µM -0.775632905388076 0.218403605116023 no 2641 0.218982882896186 3801 16488155 SGTC_3290 9121031 71.43 µM -0.777158692257074 0.217941336511544 no 2642 0.218532574917527 3791 17014854 SGTC_1259 0671-0132 43 µM -0.77994371965531 0.217099011385516 no 2643 0.21771200153781 3761 X1259 SGTC_3088 9117578 49.47 µM -0.78043523656853 0.216950548748666 no 2644 0.217567367018728 3843 678341 SGTC_556 4058-0063 51.5 µM -0.781771290811623 0.216547290366827 no 2645 0.217174498012857 3865 6615692 SGTC_2383 9036125 200 µM -0.782998957998385 0.2161771288292 no 2646 0.216813861972098 3726 79580 SGTC_1968 st069590 43.6 µM -0.783171016053207 0.21612527982972 no 2647 0.216763346363698 3805 6384066 SGTC_904 1141-0088 396 µM -0.784501561077051 0.215724568728602 no 2648 0.216372933148507 3817 1378119 SGTC_1386 3228-0095 33.8 µM -0.785018395505257 0.215569033469717 no 2649 0.21622139158725 3811 870181 SGTC_2407 paclitaxel 400 µM -0.786793160967198 0.215035433947885 no 2650 0.215701478826588 3994 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_16 erodoxin 22.806 µM -0.788817949065926 0.214427600457469 no 2651 0.21510920863398 3840 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3002 9075603 71.4286 µM -0.789309425892711 0.21428021185945 no 2652 0.214965589412485 3787 20105405 SGTC_756 0508-1999 28.3 µM -0.791986677965611 0.213478368377899 no 2653 0.214184222072172 3816 6753853 SGTC_98 0074-0023 107.663 µM -0.792269677359254 0.213393711689917 no 2654 0.214101724183953 3767 3563821 SGTC_2451 5856223 45.7 µM -0.792442973265021 0.213341881462272 no 2655 0.214051215374558 3797 2179896 SGTC_1016 4226-1401 38 µM -0.792997816637834 0.21317598543706 no 2656 0.213889547429064 3803 2901613 SGTC_977 1348-1378 135 µM -0.793363887818167 0.213066572775722 no 2657 0.213782922074746 3811 X977 SGTC_3250 9135583 49.47 µM -0.793370809142934 0.213064504421071 no 2658 0.213780906402454 3858 7699353 SGTC_2213 7173844 200 µM -0.79365554504971 0.212979424673847 no 2659 0.213697993391931 3788 892728 SGTC_757 1066-0008 322 µM -0.794071882637696 0.212855057730976 no 2660 0.21357679266071 3871 6842497 SGTC_1183 1254-0324 198 µM -0.794098553150219 0.212847092251443 no 2661 0.213569029928545 3890 5799357 SGTC_2400 5203494 178.7 µM -0.794398082025295 0.212757646185993 no 2662 0.213481860202324 3753 6777674 SGTC_1727 st034309 9.9045 µM -0.795103839756114 0.212546977827824 no 2663 0.213276550632795 3944 870305 SGTC_2495 cafestol 54.53 µM -0.795986632768889 0.212283636115737 no 2664 0.2130199024771 3810 16667697 An anti-infammatory. SGTC_3350 9150499 3.57 µM -0.797702469692244 0.211772338978947 no 2665 0.212521585165938 3801 4910996 YPR165W RHO1 SGTC_2362 9071156 126 µM -0.798662482659965 0.211486582238388 no 2666 0.212243073314601 3838 653133 SGTC_1175 0741-0056 27.6 µM -0.800750174997867 0.210865941253018 no 2667 0.211638144441773 3908 765927 SGTC_879 0831-1030 162 µM -0.800877116346998 0.210828237888906 no 2668 0.211601394546316 3875 1549252 SGTC_1627 st003713 25.6 µM -0.801506349414033 0.21064140520708 no 2669 0.211419284876252 3906 16195070 YER133W GLC7 SGTC_3101 9120531 49.47 µM -0.801581142160103 0.210619204111295 no 2670 0.211397644817237 3848 24824904 SGTC_1989 st071868 50.2 µM -0.802894975404357 0.210229436520984 no 2671 0.211017720231776 3830 16414057 SGTC_3043 9092303 49.47 µM -0.803295080787667 0.210110823682741 no 2672 0.210902100269771 3842 25236084 SGTC_3187 9109394 49.47 µM -0.804709123569969 0.209691940167121 no 2673 0.210493776730156 3810 17098090 SGTC_2115 tiliquinol 12.7705 µM -0.806482902944555 0.209167186419923 no 2674 0.209982231124746 3837 71208 A bioactive hydroxyquinoline. SGTC_1707 st032323 6.317 µM -0.806596661914778 0.209133558442489 no 2675 0.209949448777719 3727 3132057 YMR211W DML1 SGTC_67 0335-0847 266 µM -0.807399464052298 0.208896334816077 no 2676 0.209718187810727 4012 4552207 YOR254C SEC63 SGTC_960 1222-0186 7.7 µM -0.808043616965334 0.208706105844392 no 2677 0.209532736836394 3907 3126296 SGTC_285 1486-1325 46 µM -0.810810059454706 0.207890291386439 no 2678 0.208737378359366 3868 22310230 SGTC_999 SEC7.066 22.7 µM -0.811516474524958 0.207682274201261 no 2679 0.208534567965995 3842 740511 YDR170C SEC7 SGTC_1781 st038725 66.3 µM -0.811745292433658 0.207614920845986 no 2680 0.208468899709571 3844 4270275 YIL048W NEO1 SGTC_1850 st056238 17 µM -0.814836207866125 0.206706364432231 no 2681 0.207583036106074 3862 5393177 SGTC_554 4483-2211 187 µM -0.814909600116648 0.206684819865045 no 2682 0.207562028787233 3899 747107 SGTC_1539 benzyladenosine 56 µM -0.815419172201272 0.206535269761063 no 2683 0.207416206845726 3828 92208 A nucleotide analog. SGTC_2761 levamisole 97.89 µM -0.815647279567541 0.20646834518756 no 2684 0.207350950018822 3809 26879 An alkaline phosphatase inhibitor. SGTC_183 3914-0051 30.55 µM -0.815816693965124 0.206418648898953 no 2685 0.207302491899803 3880 1596232 SGTC_3089 9117425 49.47 µM -0.816838466447535 0.206119070845673 no 2686 0.207010373201937 3823 9401657 SGTC_1478 0453-0656 35.7 µM -0.817443765256995 0.20594172223243 no 2687 0.206837436802057 3872 5258496 SGTC_362 0310-0100 9.03 µM -0.817748817640073 0.205852378181917 no 2688 0.206750314480396 3941 790235 SGTC_2517 totarol 10 µM -0.820860315672536 0.204942393721103 no 2689 0.205862918846009 3878 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_575 k072-0246 11.9 µM -0.821875827308825 0.20464591701045 no 2690 0.205573785918826 3891 6796779 SGTC_3240 9133527 49.47 µM -0.822007920539286 0.204607371403079 no 2691 0.205536194522272 3809 17617455 SGTC_181 1447-1644 8.07 µM -0.823201268317458 0.204259341100988 no 2692 0.205196773875708 3863 534600 SGTC_472 calcifediol 10 µM -0.824229219329526 0.203959830231611 no 2693 0.204904663759221 3902 5283731 A vitamin D metabolite. SGTC_2922 7999257 32.47 µM -0.824238544486743 0.203957114388041 no 2694 0.204902014986136 3833 2988377 SGTC_1504 k297-0033 30 µM -0.825471899592637 0.203598103989507 no 2695 0.204551864913652 3794 4388117 SGTC_810 3825-7150 143 µM -0.826090701234947 0.203418122563577 no 2696 0.20437632106591 3890 22330411 YGL099W LSG1 SGTC_2799 7812892 81.82 µM -0.82900533714075 0.202571664046875 no 2697 0.203550693584701 3885 20205235 SGTC_627 1391-0720 175 µM -0.829216342523132 0.202510466429257 no 2698 0.203490999512884 3871 997839 SGTC_3356 9151811 4.48 µM -0.832120570907742 0.201669280344381 no 2699 0.202670445831948 3865 1859254 YPR165W RHO1 SGTC_1320 1313-0481 95.3 µM -0.832339435983859 0.201605972776269 no 2700 0.202608688449262 3867 6813365 YLR208W SEC13 SGTC_804 1595-0054 20.9 µM -0.833224446700208 0.201350101438958 no 2701 0.202359078791256 3837 761523 Stimulates phospholipase C. SGTC_1219 1469-0211 33.1 µM -0.833414426902361 0.201295200386897 no 2702 0.20230552049598 3883 6822282 SGTC_767 0929-0023 86 µM -0.833977196536509 0.201132622193193 no 2703 0.202146916979914 3913 1204563 SGTC_1479 0549-0158 134 µM -0.834793517672425 0.200896935658795 no 2704 0.201916988150721 3912 5440202 SGTC_1702 st027038 51 µM -0.836008898256063 0.200546340699679 no 2705 0.201574948590561 3920 5521182 SGTC_1416 3966-0321 25.3 µM -0.836716884637722 0.200342280749399 no 2706 0.201375862991955 3899 582530 YLR208W SEC13 SGTC_2594 a-mangostin 100 µM -0.836939332196709 0.20027819138403 no 2707 0.20131333513251 3929 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1211 1056-0033 32.3 µM -0.83745996801118 0.20012823916659 no 2708 0.2011670349404 3883 6741922 SGTC_651 3253-0966 34.4 µM -0.83825264767906 0.199900063193356 no 2709 0.200944412097314 3911 781462 SGTC_2346 9031566 143.75 µM -0.839051541601488 0.199670256789515 no 2710 0.20072019361028 3861 4771086 SGTC_880 0833-0487 87.2 µM -0.840227610696873 0.199332243180529 no 2711 0.200390390110403 3881 76075 SGTC_3287 9117173 37.0625 µM -0.840587721469301 0.19922881281158 no 2712 0.200289469857685 3864 2789709 SGTC_1331 1472-0049 76.2 µM -0.840724030913642 0.199189670692635 no 2713 0.200251277404228 3835 24051409 SGTC_1596 piperlongumine 63 µM -0.841499222450849 0.198967157630274 no 2714 0.200034160221838 3932 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_491 tetrandrine 80.3 µM -0.842417822787321 0.198703674136929 no 2715 0.199777060118082 3896 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_529 4076-0302 30.3 µM -0.843762270617093 0.198318423702801 no 2716 0.199401131340603 3850 5816522 SGTC_1892 st058411 7.36 µM -0.844017517119586 0.198245333972534 no 2717 0.19932980853402 3921 3934738 SGTC_2333 9017922 200 µM -0.844714075811002 0.198045957425939 no 2718 0.199135249289111 3948 3163164 SGTC_2393 9031399 185.94 µM -0.846483061346918 0.197540163811888 no 2719 0.198641659652052 3932 1526623 YDL150W RPC53 SGTC_1524 corynanthine 62.1 µM -0.849439742477521 0.196696526181837 no 2720 0.197818323327929 4034 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1931 st074438 57.1 µM -0.850067096767803 0.196517802574889 no 2721 0.197643891767218 3878 2787313 SGTC_1836 st055642 81 µM -0.85127182738745 0.196174869346232 no 2722 0.197309185460145 3911 8571 SGTC_299 1273-0059 1.44 µM -0.851413231580523 0.196134641671608 no 2723 0.197269922098031 3809 2848077 SGTC_1133 3473-0247 50 µM -0.851996654686374 0.195968718208495 no 2724 0.19710797439376 3918 711311 SGTC_3352 9151559 45.5865 µM -0.852068476051871 0.195948298355183 no 2725 0.197088043644624 3896 17159339 SGTC_914 3820-6779 408 µM -0.852362145173352 0.195864817406583 no 2726 0.197006561843647 3862 2893481 SGTC_3045 9092950 49.47 µM -0.852889909314448 0.195714844818822 no 2727 0.196860179004767 3859 44120432 SGTC_1406 3909-7906 11.9 µM -0.854974534517018 0.195123147114676 no 2728 0.196282622860567 3918 X1406 SGTC_2816 7982706 58.44 µM -0.855753938766577 0.194902201426022 no 2729 0.196066949009763 3978 2981853 SGTC_770 0389-1121 67.2 µM -0.856343000329266 0.194735315111911 no 2730 0.195904041490924 4047 6753108 SGTC_520 3584-0023 682 µM -0.856813693052532 0.194602026232326 no 2731 0.195773928436593 3926 1340790 SGTC_2414 st077232 92.9 µM -0.85794141522199 0.194282908301959 no 2732 0.195462406918237 3883 729801 SGTC_1838 st055369 84.5 µM -0.860554646227982 0.193544653268718 no 2733 0.194741687092019 3911 676036 SGTC_2341 7987486 176.74 µM -0.861621724116767 0.193243689354174 no 2734 0.194447856239628 3955 1258686 SGTC_433 pimozide 108 µM -0.862095445842587 0.193110170141672 no 2735 0.194317498641731 3837 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3065 9113888 49.47 µM -0.862958132267477 0.192867165337242 no 2736 0.19408024340775 3988 16648368 SGTC_605 1315-0399 119 µM -0.863172823406526 0.192806719356965 no 2737 0.194021226682089 4000 24020461 SGTC_2310 7668677 200 µM -0.863295151198551 0.192772283320153 no 2738 0.193987604727305 3907 2197143 SGTC_1788 fluconazole 20 µM -0.863603129030841 0.192685602279366 no 2739 0.193902972336421 3976 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_531 3788-1495 174 µM -0.863840660216269 0.192618764874455 no 2740 0.193837714076143 3887 2896655 SGTC_1873 rapamycin 2 nM -0.864219863894474 0.192512092509618 no 2741 0.193733561095229 3889 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_704 1310-0270 142 µM -0.865709652030386 0.192093355552819 no 2742 0.193324702801702 3926 5718033 SGTC_404 fumagillin 50 µM -0.865953066116712 0.192024991800423 no 2743 0.19325795018173 3908 12015870 A methionine aminopeptidase binder. SGTC_347 4534-1311 26.2 µM -0.866491828899004 0.191873731223797 no 2744 0.193110252696017 3917 2862016 SGTC_723 4182-0001 115 µM -0.866748184635291 0.191801783576255 no 2745 0.193039999034871 3926 744821 YLR208W SEC13 SGTC_3099 9120367 49.47 µM -0.868510667802434 0.191307580273824 no 2746 0.192557417443264 3942 24824940 SGTC_1862 st057513 3.81 µM -0.868933571118521 0.191189113666485 no 2747 0.192441733020514 3893 5393163 SGTC_771 0250-0039 27.3 µM -0.870391140335883 0.19078115403125 no 2748 0.192043343370574 3888 3005115 SGTC_1480 1070-0044 41.2 µM -0.870758742096609 0.190678350234546 no 2749 0.191942948483384 3939 3124987 SGTC_1881 5652484 16 µM -0.872485540243779 0.190195887651127 no 2750 0.191471776558146 3892 2255129 SGTC_2791 5663188 71.43 µM -0.873692440350922 0.189859128848258 no 2751 0.191142884463793 3961 54690634 SGTC_751 0833-0568 350 µM -0.874438448283917 0.189651155281783 no 2752 0.190939763334922 3991 6954252 SGTC_2441 5730946 39.09 µM -0.875410037733814 0.189380503855094 no 2753 0.190675420049863 4013 1774275 SGTC_3125 9127534 49.47 µM -0.875661071271225 0.189310613205838 no 2754 0.190607157127283 3814 1639235 SGTC_2932 9016711 44.54 µM -0.879989718970647 0.188107966103778 no 2755 0.189432439549754 3960 7117328 SGTC_1207 2099-0101 141 µM -0.880991263575373 0.187830375778716 no 2756 0.189161274304313 3972 5837381 SGTC_3310 9130229 44.1445 µM -0.882471242464377 0.187420644935346 no 2757 0.188761012218261 4021 7761258 SGTC_3277 9138724 49.47 µM -0.883179754785672 0.187224689622038 no 2758 0.188569579102755 3887 15943418 SGTC_3243 9134147 49.47 µM -0.883284834614192 0.187195638180075 no 2759 0.188541197755108 4000 24282180 SGTC_3354 9151612 71.43 µM -0.883553589988839 0.187121348009613 no 2760 0.188468620738814 3974 27261949 SGTC_42 0133-0086 60.653 µM -0.884245854689043 0.186930074109453 no 2761 0.188281754978446 3844 162923 Model of phenazepam hydroxylation. SGTC_3044 9093193 49.47 µM -0.885756940820224 0.186512978911674 no 2762 0.187874258751923 3971 25236277 SGTC_2558 carylophyllene oxide 100 µM -0.885971940239989 0.186453680903568 no 2763 0.187816323914153 4050 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2303 7774051 200 µM -0.88609051515333 0.186420982294711 no 2764 0.187784376835574 3938 2953184 SGTC_2810 7959871 45.46 µM -0.886272383810478 0.186370836497159 no 2765 0.187735383344781 3932 2974535 SGTC_874 0599-0792 117 µM -0.886329002310231 0.186355227047811 no 2766 0.187720132532132 3942 765305 SGTC_2194 5927483 104.545 µM -0.886718793884684 0.186247785360185 no 2767 0.187615158676384 3956 760979 SGTC_2473 5854593 8.94 µM -0.8874977233131 0.186033197197801 no 2768 0.187405495697434 3855 2872951 SGTC_1771 st048882 4.1505 µM -0.888023239162622 0.185888508857866 no 2769 0.187264125427112 3971 4580403 SGTC_1296 1068-0102 11.9 µM -0.889469940530749 0.185490554533434 no 2770 0.186875285592229 3975 767053 SGTC_2873 9040596 71.43 µM -0.890995608053689 0.18507145175999 no 2771 0.186465763208184 3960 6463863 SGTC_1764 st044502 93.5 µM -0.891080686386645 0.185048097965229 no 2772 0.186442942705484 4015 8407 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.89255349207116 0.184644106615719 no 2773 0.186048167273126 4023 165506 SGTC_2739 tacrine 100.86 µM -0.893013025337939 0.18451816873948 no 2774 0.185925098684821 4008 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1909 st060837 51.5 µM -0.893231897653885 0.184458204242018 no 2775 0.185866499772909 3972 678937 SGTC_3110 9122132 49.47 µM -0.89621938928551 0.183640932795049 no 2776 0.185067801056211 4070 918317 SGTC_2773 thioridazine 9.09 µM -0.897029576558121 0.183419683888218 no 2777 0.184851567489369 3993 5452 An antipsychotic. SGTC_2164 5685496 200 µM -0.900448352564898 0.18248790325601 no 2778 0.183940849413053 3874 759046 SGTC_3090 9117696 49.47 µM -0.902080557870221 0.182044093570515 no 2779 0.18350703797538 3928 7923821 SGTC_1642 st009582 77.7 µM -0.903453212743349 0.181671380590178 no 2780 0.183142704556303 3926 6739311 SGTC_956 1185-0240 191 µM -0.903534778239684 0.181649248387866 no 2781 0.183121069454042 3973 1416193 SGTC_3266 9136860 49.47 µM -0.904322733318761 0.18143552940995 no 2782 0.182912147878211 3850 4871271 YPR165W RHO1 SGTC_2071 5230951 39.92 µM -0.904922771371825 0.181272885249818 no 2783 0.182753151189384 4005 1799272 SGTC_3247 9135149 49.47 µM -0.906225075025222 0.18092020174718 no 2784 0.182408366751094 3955 8934436 YOR116C RPO31 SGTC_2436 5633522 8.09 µM -0.907236075259332 0.180646704325358 no 2785 0.182140985180419 3958 5724242 SGTC_1914 st062367 72.6 µM -0.908412066952338 0.180328899510013 no 2786 0.181830276346195 3967 978205 SGTC_385 1494-0393 12.4 µM -0.909479044879067 0.180040858771836 no 2787 0.18154865708795 3971 3090647 SGTC_710 3448-4187 58 µM -0.911541887204363 0.179484794728656 no 2788 0.181004962939064 3960 3946412 SGTC_2528 xanthyletin 44.79 µM -0.911584402963572 0.179473345458761 no 2789 0.180993767991176 4022 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1115 galangin 695.678 nM -0.912165975333438 0.179316777179464 no 2790 0.180840676044109 4015 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1474 0330-0125 5.35 µM -0.91220839997099 0.179305359172884 no 2791 0.180829511444739 3990 X1474 SGTC_2108 5365811 200 µM -0.912491442075527 0.17922919399124 no 2792 0.180755036262699 4024 780283 SGTC_2774 tamoxifen 10.92 µM -0.913497962303671 0.17895850942003 no 2793 0.180490352401016 3993 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3314 9135860 59.4275 µM -0.913664498273117 0.178913747538612 no 2794 0.18044658201575 3976 25252478 SGTC_2471 5466956 24.79 µM -0.914371736558181 0.178723733083757 no 2795 0.180260773891749 3950 724419 SGTC_149 3970-0822 46.1 µM -0.91445970102442 0.178700108465303 no 2796 0.180237671957366 3997 3114250 YBL034C STU1 SGTC_823 0417-1665 178 µM -0.915128138908866 0.178520650333864 no 2797 0.18006218214708 3974 3429856 SGTC_382 3229-0966 23.2 µM -0.917313857848478 0.177934634632196 no 2798 0.179489098857342 4012 5722370 SGTC_341 1486-1430 230 µM -0.919070166355559 0.177464628758785 no 2799 0.179029436319325 3973 2054753 YPL210C SRP72 SGTC_2721 ifenprodil 61.44 µM -0.921785661098541 0.176739479135206 no 2800 0.178320194110029 3968 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1034 k072-0165 12.7 µM -0.921988418043265 0.176685409889381 no 2801 0.178267308485456 4049 5835461 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.922617177655206 0.176517804916877 no 2802 0.178103370331356 4046 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3353 9151644 39.2805 µM -0.923362586934339 0.176319235609685 no 2803 0.177909140969671 4046 4909158 SGTC_871 0574-0004 149 µM -0.923690557117897 0.176231912544334 no 2804 0.17782372496411 3985 9551173 SGTC_2378 9074213 121.43 µM -0.924881792020967 0.175914972899028 no 2805 0.177513699395447 3964 657714 SGTC_454 lyso-paf C-16 6.67 µM -0.925013107008948 0.175880057369804 no 2806 0.177479544821979 3969 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_839 0122-0028 230 µM -0.925265155612209 0.175813052105592 no 2807 0.177413999476581 3988 759448 SGTC_1949 st076024 69.1 µM -0.925594802898697 0.175725442209281 no 2808 0.177328297627899 3925 2921930 SGTC_3259 9138485 49.47 µM -0.926101073549147 0.175590945236612 no 2809 0.177196728069692 4031 17646153 SGTC_720 r052-1644 49.9 µM -0.926765964950709 0.175414407850149 no 2810 0.177024029854083 4031 1422863 YOR257W CDC31 SGTC_2082 5219693 150 µM -0.928564698411202 0.174937384698671 no 2811 0.176557361880551 3998 2834649 SGTC_1163 k060-0048 49.9 µM -0.928829764582957 0.174867158945823 no 2812 0.1764886582742 3998 6809982 SGTC_705 1124-0212 310 µM -0.930305246376953 0.174476576741732 no 2813 0.176106531112868 3953 9554485 SGTC_3112 9123419 49.47 µM -0.930721078231643 0.174366599966624 no 2814 0.175998931712351 4043 17015854 SGTC_846 0335-0850 148 µM -0.930733653428586 0.174363274838333 no 2815 0.175995678440773 3994 6819598 SGTC_157 1348-1695 65.819 µM -0.930752786997451 0.174358215625371 no 2816 0.175990728555889 3968 5380510 SGTC_843 0310-0051 143 µM -0.932102414528076 0.174001588448382 no 2817 0.175641800171391 4027 2065037 SGTC_1068 loratadine 26.9 µM -0.932712626348716 0.173840497706823 no 2818 0.175484181961376 4043 3957 A H1 histamine antagonist. SGTC_1160 4092-0570 10.5 µM -0.935225961774478 0.173177998787651 no 2819 0.174835930864209 4005 4994975 SGTC_1723 st034307 2.5525 µM -0.935459725820224 0.173116461937483 no 2820 0.174775714713297 4066 867466 SGTC_504 lovastatin 124 µM -0.935550523460937 0.173092563810662 no 2821 0.174752329361154 4036 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2172 5754775 163.918 µM -0.937672807743805 0.172534572870906 no 2822 0.174206291117184 3984 2263357 SGTC_1022 4477-0945 21.3 µM -0.940799558057979 0.171714580182622 no 2823 0.173403793712414 3969 4648966 SGTC_3005 9076496 71.4286 µM -0.941325623107585 0.171576864260468 no 2824 0.173269007900601 4010 21368410 SGTC_274 sirtinol 40.1 µM -0.941918289538138 0.171421797661231 no 2825 0.173117237745361 4083 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2893 9048488 25.97 µM -0.942872073300713 0.171172435630726 no 2826 0.172873170421338 4062 6467338 SGTC_2817 7995342 71.43 µM -0.94386337526849 0.170913510610618 no 2827 0.172619734927427 4029 18879975 SGTC_103 0844-0104 51.839 µM -0.94707311258269 0.170076857482134 no 2828 0.171800762268091 3963 5375804 SGTC_2100 5377183 190 µM -0.947274736950241 0.170024389652947 no 2829 0.171749400265781 4048 2844202 SGTC_1827 berberine 7.24 µM -0.947998126491897 0.169836230546097 no 2830 0.171565203986658 3973 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2274 7947094 46.08 µM -0.94900284278432 0.16957511781215 no 2831 0.171309583118638 3991 2971028 SGTC_2311 7694451 200 µM -0.949094861688226 0.169551216173436 no 2832 0.171286183759424 4010 2163142 SGTC_2499 avocadenofuran 51.48 µM -0.949260810610171 0.169508116894937 no 2833 0.171243990004343 3999 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2666 tannic acid 100 µM -0.95100424521183 0.169055747234317 no 2834 0.170801110426495 4037 16134267 A thiamine antagonist. SGTC_1171 0368-0077 21.4 µM -0.951448717431288 0.168940543994875 no 2835 0.170688319814205 3979 3239779 SGTC_2087 5276107 200 µM -0.952671386841697 0.168623899214084 no 2836 0.170378297561352 3996 144405 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.953804229249285 0.168330858377564 no 2837 0.170091374109791 3994 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_675 1309-0189 238 µM -0.95449697085944 0.168151823198368 no 2838 0.169916070943489 4063 4246530 SGTC_1414 3917-0015 5.4 µM -0.954711639750427 0.168096368103588 no 2839 0.169861770978841 3987 6618702 SGTC_1979 st071809 45.3 µM -0.955279271039475 0.16794978946599 no 2840 0.169718243662532 4129 4976333 SGTC_1413 3910-0535 34.4 µM -0.95544479993299 0.167907060668582 no 2841 0.169676403825696 4032 2876951 SGTC_2022 5136654 200 µM -0.956116066094657 0.167733855129076 no 2842 0.169506799357313 4099 1713771 SGTC_1819 st053448 58.6 µM -0.956320569211375 0.167681110449582 no 2843 0.169455150506429 3954 2857616 SGTC_1033 k072-0102 21.3 µM -0.957176575917472 0.16746044834427 no 2844 0.169239068983165 4028 5965931 SGTC_2626 ethyl orsellinate 100 µM -0.958231990761367 0.167188640315988 no 2845 0.16897289453836 4036 75653 A natural product. SGTC_2389 9091542 195.52 µM -0.961872662171296 0.166253217938926 no 2846 0.168056786241523 4032 3626624 YOL127W RPL25 SGTC_3013 9080133 71.4286 µM -0.963275569513971 0.165893663449101 no 2847 0.167704625039111 4139 17050193 SGTC_2859 9028643 45.46 µM -0.967734416956471 0.164754234667354 no 2848 0.166588512415233 3931 17151580 SGTC_951 1171-0579 82.7 µM -0.969872319737465 0.164209710323083 no 2849 0.166055069486166 4003 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3300 9124615 50.48 µM -0.970391486442984 0.164077654765904 no 2850 0.165925695342076 4103 24824903 SGTC_3280 9140961 49.47 µM -0.971611906058866 0.163767499480221 no 2851 0.165621828574064 4095 4901226 SGTC_3227 9130768 49.47 µM -0.973888320972978 0.163189993030776 no 2852 0.165055996615093 4103 17720899 SGTC_981 1488-1094 54.9 µM -0.975288135987795 0.162835530168623 no 2853 0.164708676898311 4032 3449522 SGTC_1534 6-azauridine 81.6 µM -0.975860952753125 0.162690625277955 no 2854 0.16456668720046 4081 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1287 0971-0001 34.6 µM -0.976761855156327 0.16246289464073 no 2855 0.164343532240539 4043 4665869 SGTC_2894 9048625 32.47 µM -0.97718398916932 0.162356258767113 no 2856 0.164239036506174 4039 4092861 SGTC_2327 6189656 200 µM -0.977856017943722 0.162186590640648 no 2857 0.164072770334849 4147 5349088 SGTC_1011 4112-3381 17.4 µM -0.979931654892179 0.161663280666737 no 2858 0.163559928113837 4146 2877139 SGTC_913 3487-1245 167 µM -0.980714413242674 0.161466217587596 no 2859 0.16336679708421 3993 4016153 SGTC_935 2996-0153 430 µM -0.981641371588989 0.16123305414492 no 2860 0.16313827906455 4099 23738523 SGTC_3291 9121177 71.43 µM -0.981698960429545 0.161218575725794 no 2861 0.163124088856995 4086 17015612 SGTC_2008 4012253 172 µM -0.989280175813514 0.159319987112674 no 2862 0.161263040277946 4062 603940 SGTC_338 4055-0136 114 µM -0.989358945441739 0.159300337740647 no 2863 0.161243776773119 4026 2900563 SGTC_124 0136-0217 7.121 µM -0.989661907881952 0.159224777441851 no 2864 0.161169699790167 4115 3976905 SGTC_2170 morpholine 200 µM -0.989925316465546 0.159159101145991 no 2865 0.161105312120767 4117 121171 Reacts with secondary amines. SGTC_537 1334-0398 209 µM -0.990011741687716 0.159137556404144 no 2866 0.161084189972328 4131 5846986 SGTC_2958 9077254 16.72 µM -0.990889297564573 0.15891890073786 no 2867 0.160869819439215 4156 16457351 SGTC_975 1335-0046 28.5 µM -0.991073007210095 0.158873151772193 no 2868 0.160824966185057 4095 16486740 SGTC_1950 st077106 7.18 µM -0.99658064148658 0.157505601886536 no 2869 0.159484053147967 4048 13831864 SGTC_1921 5740136 50 µM -0.997551060122446 0.157265450153966 no 2870 0.159248551273509 4037 1774243 SGTC_1147 3809-1045 12.3 µM -0.998578158262153 0.157011534193862 no 2871 0.158999542594946 4056 325925 SGTC_392 N-ethylmaleimide 8.33 µM -0.999858417793601 0.15669541024978 no 2872 0.158689515105733 4025 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3028 9087778 49.47 µM -1.002637452236 0.156010648785516 no 2873 0.1580179092949 4070 17217395 SGTC_679 0422-0091 41.4 µM -1.00402235746876 0.155670141886039 no 2874 0.157683918640875 4091 627384 YHR062C RPP1 SGTC_610 4215-0184 155 µM -1.00545549265198 0.155318293107956 no 2875 0.157338785218762 4121 5605015 SGTC_685 1278-0033 54.9 µM -1.00640336449004 0.155085869835521 no 2876 0.157110787924683 4152 3590572 SGTC_1458 k015-0034 6.33 µM -1.0073153873876 0.154862453806904 no 2877 0.15689161880615 4124 3598957 SGTC_2824 7998404 51.95 µM -1.00959510726259 0.154304926710258 no 2878 0.156344657353152 4059 837851 SGTC_598 3937-0236 20.2 µM -1.00998227790301 0.154210372474855 no 2879 0.156251890407038 4168 1379313 SGTC_2477 5967686 25.23 µM -1.01123114578189 0.153905637042838 no 2880 0.155952906057845 4086 776118 SGTC_1607 st000305 50.6 µM -1.01376608651053 0.153288314019931 no 2881 0.155347190630324 4122 5457690 SGTC_212 3807-4682 38.772 µM -1.01499421600127 0.15298982379171 no 2882 0.155054292323054 4169 3125501 YBL034C STU1 SGTC_924 2046-0044 21.3 µM -1.01566543235073 0.15282685124561 no 2883 0.154894367211183 4094 3623589 SGTC_2345 9052315 157.45 µM -1.01718610571068 0.152458055022445 no 2884 0.154532452234308 4155 6469265 SGTC_307 1501-1223 22.3 µM -1.01848122284336 0.152144427152462 no 2885 0.154224659934191 4141 2830329 SGTC_1609 st001574 46.4 µM -1.01946026741064 0.151907624520754 no 2886 0.153992253445864 4092 3960012 SGTC_423 5-fluorouracil 457 µM -1.0207502183284 0.151595996640082 no 2887 0.15368639770224 4051 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_565 1418-0001 44.5 µM -1.02197333771884 0.151300906770264 no 2888 0.153396759872201 4187 2862145 SGTC_1097 itavastatin 7.23 µM -1.0252347609152 0.150515924278714 no 2889 0.152626215065775 4124 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1824 st053723 68.6 µM -1.02596159039381 0.150341356121042 no 2890 0.152454844621504 4154 675225 SGTC_2158 5657123 3.6195 µM -1.02673753987684 0.150155139390393 no 2891 0.152272033742193 4065 2858827 SGTC_105 0111-0055 734.78 µM -1.02708680669504 0.150071370569217 no 2892 0.152189795262656 4123 5179370 SGTC_2432 5630864 12.22 µM -1.02769248891921 0.149926176463218 no 2893 0.152047251053768 4170 5714970 SGTC_1274 0865-0114 173 µM -1.02794395335135 0.149865922954315 no 2894 0.151988096245546 4115 870624 SGTC_2513 baicalein 25.65 µM -1.02846792616547 0.14974042547876 no 2895 0.151864885343021 4129 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1720 st037298 9.481 µM -1.02919457152582 0.14956650167278 no 2896 0.151694126353412 4137 597396 SGTC_2472 5377652 49.4 µM -1.0313685014671 0.149046973077056 no 2897 0.151184023031023 4192 1610903 SGTC_583 1488-1091 88.9 µM -1.03247840038351 0.148782193382511 no 2898 0.150924030555657 4242 4303273 SGTC_2887 9044784 58.44 µM -1.03391937844119 0.148438900078917 no 2899 0.150586927438616 4099 6465546 SGTC_1074 carmofur 3.8 µM -1.0341855044712 0.148375557191184 no 2900 0.150524724687137 4163 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1485 3909-9022 254 µM -1.03868344387372 0.147307700008654 no 2901 0.149475991758272 4161 714516 SGTC_296 1222-0039 74.9 µM -1.04002165335587 0.146990991945954 no 2902 0.149164920377908 4138 5984176 SGTC_609 0986-0026 86.3 µM -1.04083468734365 0.146798797976119 no 2903 0.148976139117153 4094 2848610 SGTC_870 0573-2213 57.6 µM -1.04192132467509 0.146542189963754 no 2904 0.148724078252445 4128 3916321 SGTC_1226 3909-7979 35.4 µM -1.04251763011442 0.146401501213739 no 2905 0.148585877996071 4126 6615510 SGTC_2751 anetholtrithion 17.25 µM -1.04430156402274 0.145981152072021 no 2906 0.14817294474902 4137 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3038 9091290 49.47 µM -1.04841830140097 0.145014220992923 no 2907 0.147222962585162 4175 25236843 SGTC_1375 2910-0797 186 µM -1.0486958298427 0.14494919114088 no 2908 0.147159067085706 4142 742508 SGTC_1932 st074806 40.9 µM -1.048742106534 0.144938349598729 no 2909 0.147148414590713 4220 17251235 SGTC_451 chloral hydrate 100 µM -1.04876696965617 0.14493252497847 no 2910 0.14714269152804 4158 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_43 0570-0105 72.5 µM -1.05265763984784 0.144023009086635 no 2911 0.146248964790039 4140 1114046 YDL195W SEC31 SGTC_1694 st024011 44.9 µM -1.06572271979435 0.14099701802713 no 2912 0.143274502043732 4185 2787533 SGTC_1808 st050063 61.5 µM -1.06730797382076 0.140632814026509 no 2913 0.142916394289282 4145 4011993 SGTC_249 wiskostatin 11.211 µM -1.07306168996395 0.139316294880599 no 2914 0.141621719142425 4123 2775510 A n-wasp and actin depolymerizer. SGTC_2595 hexamethylquercetagetin 100 µM -1.07336490353707 0.139247149346457 no 2915 0.141553712492309 4153 386331 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.07339927210216 0.139239313332052 no 2916 0.141546005490399 4110 279621 SGTC_1851 st056236 18.9 µM -1.07382440838482 0.139142407301001 no 2917 0.141450694030063 4183 5393171 SGTC_295 k015-0027 31 µM -1.07497696768869 0.138879922616231 no 2918 0.141192520156524 4195 3887424 SGTC_305 1682-2595 20.8 µM -1.08025374778034 0.137682492125629 no 2919 0.140014599999123 4189 226033 SGTC_3029 9088683 49.47 µM -1.08380885513248 0.136879735242394 no 2920 0.13922477908612 4215 25236615 SGTC_1157 4092-0394 27.6 µM -1.08450256912729 0.136723465732849 no 2921 0.139071014244856 4266 3659885 SGTC_3200 9114385 49.47 µM -1.08469043098693 0.136681168019938 no 2922 0.139029393713543 4202 17018030 YLR208W SEC13 SGTC_3177 9107506 49.47 µM -1.08541251682495 0.136518671320499 no 2923 0.138869495548969 4132 8897194 SGTC_3336 9143619 71.43 µM -1.08591777483895 0.136405047707555 no 2924 0.138757686076742 4213 45595730 SGTC_1417 3966-0327 90.4 µM -1.08760654232181 0.136025743253966 no 2925 0.138384420661574 4278 651118 SGTC_2198 6589944 200 µM -1.08862326978318 0.135797730414725 no 2926 0.138160025451589 4175 5290268 SGTC_2416 tofa 880 nM -1.08907605466201 0.135696272480416 no 2927 0.138060174178834 4185 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3276 9139060 49.47 µM -1.08916264575197 0.135676875466741 no 2928 0.13804108411636 4261 4870619 SGTC_2243 6634756 200 µM -1.08947444710805 0.135607045501517 no 2929 0.13797235861525 4245 885676 SGTC_1351 1496-0003 46.5 µM -1.09234060792214 0.134966303349473 no 2930 0.137341708867931 4209 3891978 SGTC_2652 actinonin 100 µM -1.09332205539406 0.134747374744442 no 2931 0.137126211260089 4193 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_449 xestospongin c 11.1929 µM -1.09835019312711 0.13362958585362 no 2932 0.136025801129477 4204 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_769 0302-0231 76 µM -1.09881656959165 0.133526231283963 no 2933 0.135924041656798 4110 571869 YER009W NTF2 SGTC_94 0334-0113 514.748 µM -1.1007883552806 0.133089867779128 no 2934 0.135494390496291 4211 6795178 SGTC_842 0271-0008 11.1 µM -1.10292143617657 0.132618915394411 no 2935 0.135030642151178 4234 1221709 SGTC_728 3030-5151 22.5 µM -1.10387045995695 0.132409754570661 no 2936 0.134824667311776 4261 3125388 SGTC_147 4466-0538 29.23 µM -1.10574121627234 0.131998113833231 no 2937 0.134419272432029 4311 6742687 YHR072W ERG7 SGTC_2576 guaiol 23.12 µM -1.10786369543402 0.131532153787255 no 2938 0.13396034331399 4111 227829 SGTC_474 dl-dihydrosphingosine 5 µM -1.11481057198221 0.13001501118155 no 2939 0.132465802565324 4231 3058739 A sphingolipid protein kinase C inhibitor. SGTC_419 nsc-638432 893 µM -1.11584819529621 0.129789446434614 no 2940 0.132243559924287 4155 368090 SGTC_2611 pyromycin 23.93 µM -1.11614313310456 0.129725380583513 no 2941 0.132180435812209 4171 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2617 dihydrotanshinone i 20.83 µM -1.11687355757833 0.129566813407447 no 2942 0.132024196034201 4176 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_61 0978-8327 98.565 µM -1.11757790002063 0.129414035566315 no 2943 0.131873655937946 4128 6150059 YHR072W ERG7 SGTC_1963 st076565 50.3 µM -1.11810577283145 0.129299617348853 no 2944 0.131760910597608 4222 4914280 SGTC_370 0180-0345 38.7 µM -1.12024709219953 0.128836198293031 no 2945 0.131304240603417 4066 3989527 SGTC_3238 9133470 49.47 µM -1.12300820432097 0.128240347613437 no 2946 0.130717005017491 4208 3534688 SGTC_1573 oleylamine 1.06 µM -1.12451723333114 0.127915507649655 no 2947 0.130396831897024 4211 5356789 An amine of the fatty acid oleic acid. SGTC_1346 1488-2224 62.4 µM -1.12704341116414 0.127372992483571 no 2948 0.129862063595207 4231 3722427 SGTC_1102 cgs 12066b 26.1 µM -1.12967621307031 0.126809284286364 no 2949 0.129306341947907 4231 6438352 A 5-HT1B full agonist. SGTC_2937 9044753 11.33 µM -1.13017953077967 0.126701717199041 no 2950 0.129200291535322 4160 6465530 YGL099W LSG1 SGTC_3142 9086498 49.47 µM -1.1316479626917 0.12638825286128 no 2951 0.128891233546775 4104 25236367 SGTC_1195 1502-0147 41.1 µM -1.13610676389347 0.125439751089133 no 2952 0.127955942289404 4205 817940 SGTC_708 3448-5400 146 µM -1.1369191823545 0.125267465269355 no 2953 0.127786036150703 4186 3462195 SGTC_2403 6032726 181.2 µM -1.13693458445627 0.125264200613498 no 2954 0.127782816528332 4276 2881040 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.13720889043395 0.125206068198589 no 2955 0.127725485637248 4210 688803 SGTC_1970 st070122 35.8 µM -1.13814842562709 0.125007099559634 no 2956 0.12752925505835 4257 102928 SGTC_122 0236-0016 402.397 µM -1.13905669282477 0.124814962712411 no 2957 0.127339754458694 4224 6808838 SGTC_1804 st050076 49.1 µM -1.13939647081795 0.124743138390821 no 2958 0.127268913644308 4257 3895976 SGTC_293 4049-0273 38.5 µM -1.14014525227436 0.124584958427804 no 2959 0.127112895887602 4095 1380311 SGTC_2016 5121758 140 µM -1.14101571818571 0.124401248954159 no 2960 0.126931691038692 4153 2795203 SGTC_3218 9131285 49.47 µM -1.14355672567672 0.123866060093555 no 2961 0.126403758465236 4209 17156417 SGTC_824 1304-0008 100 µM -1.14499068182603 0.123564751555885 no 2962 0.12610650868978 4253 768245 SGTC_1450 4112-4260 37.6 µM -1.14632453886551 0.123284937391899 no 2963 0.125830446583316 4245 1633175 SGTC_802 4112-3352 742 µM -1.14858928254085 0.12281086097166 no 2964 0.125362689215146 4302 704594 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.14890120940774 0.122745665951108 no 2965 0.125298359451754 4232 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_873 0591-4978 488 µM -1.14933923257541 0.1226541568544 no 2966 0.125208063319132 4302 3305145 SGTC_2928 9011484 9.79 µM -1.15122465584791 0.122260812240078 no 2967 0.124819912155209 4250 2994751 SGTC_2659 sanguinarine 24.21 µM -1.15142667223683 0.122218719347759 no 2968 0.124778373065593 4184 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1358 1509-0022 2.48 µM -1.15225485039075 0.122046263395064 no 2969 0.124608182088802 4273 3258434 SGTC_2975 9084847 53.72 µM -1.15357339713235 0.12177204813048 no 2970 0.124337555097195 4300 27211724 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.15546559544054 0.121379288622028 no 2971 0.123949906814359 4288 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1062 mesoridazine 14.2 µM -1.15944655415734 0.120555879952544 no 2972 0.123137104957406 4286 4078 A neuroleptic. SGTC_163 TUB2.036 7.546 µM -1.15959690163403 0.120524859829982 no 2973 0.12310648153131 4221 15992207 YJR013W GPI14 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.1601173281527 0.120417527340626 no 2974 0.123000520021752 4257 5379071 SGTC_876 0720-0963 56.8 µM -1.16058790930432 0.120320532907713 no 2975 0.122904762345578 4277 765861 SGTC_234 nsc-17383 10.7 µM -1.16323493684218 0.119775962945628 no 2976 0.12236709766419 4269 408974 SGTC_825 1988-2224 89.6 µM -1.16330214306119 0.119762159346374 no 2977 0.122353468248072 4240 1180859 SGTC_791 1348-1292 225 µM -1.16400867626443 0.119617111176652 no 2978 0.122210247846168 4221 5437054 SGTC_379 3970-0972 5.9 µM -1.16437555379462 0.119541841722662 no 2979 0.122135925035252 4236 2898042 YBL034C STU1 SGTC_2658 polymyxin b sulfate 77.05 µM -1.16439626122106 0.119537594334878 no 2980 0.12213173102827 4275 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1484 3473-2379 286 µM -1.16520647804032 0.119371490903124 no 2981 0.121967712032144 4378 671917 SGTC_1983 st071813 46.9 µM -1.16533182411921 0.119345808121727 no 2982 0.121942350997865 4311 11838595 SGTC_1835 st008666 49.2 µM -1.16761103308622 0.118879489615169 no 2983 0.121481848875072 4188 690455 SGTC_1161 k007-0610 110 µM -1.16867439861681 0.118662369406255 no 2984 0.121267420242467 4231 5843850 SGTC_2258 7960471 200 µM -1.17240520509447 0.117902821916633 no 2985 0.120517205363546 4283 2974708 SGTC_1365 1672-3266 55.4 µM -1.17433587085117 0.117511114924623 no 2986 0.120130260392321 4278 6415873 SGTC_696 1560-0013 611 µM -1.17706226034136 0.116959536531596 no 2987 0.119585328444457 4309 1650269 SGTC_2425 5628681 7.85 µM -1.18084044237799 0.116198205915414 no 2988 0.118833057329254 4336 5714958 SGTC_2190 6049624 200 µM -1.18176622732337 0.116012191316343 no 2989 0.118649235923798 4154 2265554 SGTC_2325 6158266 200 µM -1.18257289704388 0.115850282532638 no 2990 0.118489229597003 4271 3623240 SGTC_3080 9117754 49.47 µM -1.18402726408176 0.11555877829398 no 2991 0.118201135249731 4277 9550191 SGTC_2835 9006588 71.43 µM -1.18407595718148 0.115549027577372 no 2992 0.11819149825135 4320 2345538 SGTC_3046 9092212 49.47 µM -1.1856032197563 0.11524349230139 no 2993 0.117889515069684 4344 25236637 SGTC_479 n-linoleoylglycine 10 µM -1.18815138571489 0.11473500030864 no 2994 0.117386886303137 4315 6433346 An anti-infammatory. SGTC_3140 9094243 49.47 µM -1.19097077538143 0.11417424764102 no 2995 0.116832528943496 4254 19291112 SGTC_668 1682-0499 62.6 µM -1.19100980652268 0.114166498400697 no 2996 0.116824867561758 4239 682214 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.1928231238848 0.113806895367463 no 2997 0.116469325934301 4306 6728940 SGTC_1910 st062352 60.4 µM -1.19410637072411 0.11355290005996 no 2998 0.116218180753173 4181 2245730 SGTC_2342 7990637 118.86 µM -1.19796071626869 0.112792433576778 no 2999 0.11546615533937 4307 2033102 YER133W GLC7 SGTC_794 k038-0031 316 µM -1.20018461925343 0.112355312956576 no 3000 0.115033823708335 4276 6624242 SGTC_1995 st072814 61.1 µM -1.20186158343843 0.112026497681034 no 3001 0.114708580355963 4240 5769371 SGTC_426 0988-0037 14.6 µM -1.20498260612338 0.111416367639947 no 3002 0.114105008384416 4333 5383008 SGTC_1112 tnp00069 1.16933 µM -1.20665975592373 0.111089485039636 no 3003 0.113781601820369 4299 145826 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.20686082914509 0.11105034129056 no 3004 0.113742872560133 4320 6708561 SGTC_140 0062-0056 502.533 µM -1.20714363692926 0.110995302657556 no 3005 0.113688416086588 4209 3758964 SGTC_354 2783-3500 4.88 µM -1.20875495501841 0.110682088778828 no 3006 0.11337850092814 4299 6740761 SGTC_137 0438-0332 85.389 µM -1.21033276199713 0.110376003191312 no 3007 0.11307561552827 4248 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1768 st044301 37.178 µM -1.21033294786258 0.110375967170259 no 3008 0.113075579882457 4300 3931349 SGTC_618 k072-0232 33.2 µM -1.21051788379972 0.11034013043617 no 3009 0.113040116307819 4342 5872756 YGL099W LSG1 SGTC_316 k060-0003 58.6 µM -1.21127955176764 0.110192622988865 no 3010 0.112894141457499 4332 6152314 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.21379650589314 0.109706186400419 no 3011 0.112412720468483 4314 94937 An inhibitor of serotonin biosynthesis. SGTC_2031 5180455 200 µM -1.21424638118223 0.109619404349022 no 3012 0.112326826995079 4276 29949 SGTC_1228 0124-0032 52.5 µM -1.2154281655946 0.109391670056374 no 3013 0.112101415526083 4358 X1228 SGTC_1355 1499-0035 1.68 µM -1.21746277324348 0.109000390070757 no 3014 0.111714095986019 4294 1548538 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.21782686293535 0.108930477409374 no 3015 0.111644886892622 4326 65057 A dermal irritant. YDR527W RBA50 SGTC_1025 k007-0731 70 µM -1.22300100895502 0.107940417992231 no 3016 0.110664657606857 4268 6256118 SGTC_17 0960-0276 49.807 µM -1.22536119694119 0.107490960653954 no 3017 0.110219580097146 4283 6821114 SGTC_211 3455-0679 143.504 µM -1.2277392762231 0.107039461982221 no 3018 0.109772428687784 4332 748649 SGTC_982 1491-0518 27.5 µM -1.22829372499003 0.10693439206567 no 3019 0.109668362864215 4239 3091256 SGTC_2662 daunorubicin 22.37 µM -1.22902955459218 0.106795064790386 no 3020 0.109530362636004 4191 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2934 9036370 36.88 µM -1.23109436103609 0.106404799091241 no 3021 0.109143787164854 4292 6462800 SGTC_142 0335-0849 62.6745 µM -1.23247733420992 0.106143982094067 no 3022 0.108885414170558 4292 3889043 YPR107C YTH1 SGTC_1197 1601-0112 267 µM -1.2354617043475 0.105582729557871 no 3023 0.108329360250603 4288 7350313 SGTC_2233 sulbentine 40.3845 µM -1.23564647587846 0.10554805136817 no 3024 0.108295000542328 4325 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2737 bleomycin 30.5 nM -1.23752755213757 0.105195476932971 no 3025 0.107945646032724 4413 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_518 1021-0119 62.6 µM -1.24075592178107 0.104592364060264 no 3026 0.107347964468008 4288 1097762 SGTC_2033 5192550 145 µM -1.24270793401734 0.104228913153099 no 3027 0.106987739589849 4325 182073 SGTC_1304 1165-0502 251 µM -1.24765749636797 0.103311445052501 no 3028 0.106078256441568 4306 767425 SGTC_45 0kpi-0036 14.9 µM -1.24770653928866 0.103302383716248 no 3029 0.106069272828881 4341 2795021 SGTC_2075 5212009 200 µM -1.24784026819766 0.103277678441623 no 3030 0.10604477934992 4248 780898 SGTC_1962 st076595 64.5 µM -1.24904154913095 0.103055944368998 no 3031 0.105824938723153 4299 279619 SGTC_15 0266-0086 27.098 µM -1.25689029481037 0.101615717935468 no 3032 0.104396681663023 4395 1712902 YIL048W NEO1 SGTC_3030 9087619 49.47 µM -1.26121321221967 0.100828759549831 no 3033 0.103616019846233 4355 25236973 SGTC_2768 sulfasalazine 50.2 µM -1.26138495669322 0.100797586652525 no 3034 0.103585092786179 4331 5384001 An antioxidant and salicylic acid derivative. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.26166060044877 0.100747569956399 no 3035 0.103535469961668 4332 616764 SGTC_2854 9024559 71.43 µM -1.26302813644879 0.100499692549532 no 3036 0.103289534113985 4352 3163529 SGTC_1114 scopoletin 1.73284 µM -1.26607371439514 0.0999492554597691 no 3037 0.102743346167564 4362 5280460 A coumarin with genotoxic properties. SGTC_2401 5128683 200 µM -1.26613173407065 0.0999387907909193 no 3038 0.102732961446487 4354 708373 SGTC_1336 1486-0901 104 µM -1.26883961009492 0.0994512768342271 no 3039 0.102249137284353 4343 5006114 SGTC_1275 0867-0008 21.1 µM -1.26901885662116 0.0994190675350291 no 3040 0.10221716936538 4316 3422836 SGTC_1442 4112-3290 3 µM -1.27286977755542 0.0987289256622709 no 3041 0.101532127659572 4336 704353 SGTC_2388 9080168 200 µM -1.27307421036459 0.0986923865377249 no 3042 0.101495854720646 4358 15943073 SGTC_1173 0443-0020 122 µM -1.27406896169681 0.0985147317501091 no 3043 0.101319488613522 4342 5331295 SGTC_2496 diffractaic acid 79.83 µM -1.27692243096428 0.0980064237901213 no 3044 0.100814817042345 4345 94870 An apoptosis inducer which activates caspases. SGTC_1886 st057356 49.9 µM -1.27867101766806 0.0976958873131241 no 3045 0.100506464897938 4331 24207747 SGTC_2676 harmalol 100 µM -1.28177646122768 0.0971461621411988 no 3046 0.099960536870307 4318 5459187 A monoamine oxidase inhibitor SGTC_1661 st013063 9.66 µM -1.28221176648064 0.0970692862350992 no 3047 0.0998841848468402 4421 721395 SGTC_2942 9052777 62.25 µM -1.28817927695706 0.0960199084294892 no 3048 0.0988417819726465 4397 6469503 SGTC_732 3970-1727 52.7 µM -1.2909832528435 0.0955297240922079 no 3049 0.0983547423828349 4437 1275699 SGTC_246 cycloheximide 667 µM -1.29178600139557 0.0953897291971666 no 3050 0.0982156322577297 4258 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2714 st079313 56.9 µM -1.29191527439338 0.0953671988290914 no 3051 0.0981932437257577 4347 2939799 SGTC_395 anisomycin 6.25 µM -1.29222886582094 0.095312560768145 no 3052 0.0981389489883702 4371 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1150 3909-7983 10.9 µM -1.29226188620205 0.0953068088604684 no 3053 0.0981332331705295 4348 23965914 SGTC_1992 st073643 23.3 µM -1.29424458574787 0.0949619053779748 no 3054 0.0977904753233847 4341 3161292 SGTC_3286 9117135 37.221 µM -1.29431859104887 0.0949490494988422 no 3055 0.0977776987182125 4320 3438150 SGTC_3035 9091303 49.47 µM -1.29584068501452 0.0946849222603402 no 3056 0.0975151889817752 4430 25237002 SGTC_1684 st024538 14.6195 µM -1.29992371959735 0.0939790733109493 no 3057 0.0968135572989652 4313 6732859 SGTC_2845 9003024 42.97 µM -1.30199702740313 0.0936221430556738 no 3058 0.0964587008889631 4410 2990173 SGTC_633 0437-0093 97.7 µM -1.30298520839436 0.093452375447634 no 3059 0.0962899057457169 4302 2831118 SGTC_1050 3232-1156 69.3 µM -1.30534534024734 0.093047829547551 no 3060 0.0958876408305837 4335 700529 SGTC_2204 7233102 200 µM -1.30562902820491 0.0929992903907944 no 3061 0.0958393719060959 4301 2172480 SGTC_1942 st076330 65.2 µM -1.30697422759933 0.0927693808645199 no 3062 0.0956107322801433 4422 24208414 SGTC_1169 aniline yellow 25.8 µM -1.31528716629663 0.0913579248846807 no 3063 0.0942067048182028 4303 6051 A DNA damaging agent. SGTC_580 1123-0028 41 µM -1.31709754109318 0.0910526629892253 no 3064 0.0939029655741231 4434 1677248 YPR107C YTH1 SGTC_1151 3909-8316 15.3 µM -1.31846697188946 0.0908222552809327 no 3065 0.0936736871841614 4413 800431 SGTC_638 3970-0837 4.09 µM -1.31892260168814 0.0907456912385672 no 3066 0.0935974945999714 4359 4118451 YLR208W SEC13 SGTC_1670 st016595 4.04 µM -1.31991150652613 0.0905796804625026 no 3067 0.093432282695045 4390 597879 SGTC_1076 itraconazole 331 nM -1.32248854256483 0.0901481241706376 no 3068 0.093002761058629 4377 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2285 7945142 200 µM -1.32281694170968 0.090093239615918 no 3069 0.0929481308989351 4411 2970608 SGTC_2083 5306046 65.942 µM -1.32350170995895 0.0899788758151821 no 3070 0.0928342940083518 4374 539837 SGTC_272 doxorubicin 8.13 µM -1.32831183315551 0.0891785713575241 no 3071 0.0920375560900119 4415 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2648 atorvastatin 78.68 µM -1.32880099575501 0.0890974825392054 no 3072 0.0919568167977503 4380 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3193 9111931 49.47 µM -1.33474636588531 0.0881162971749412 no 3073 0.0909796864064831 4381 17087244 SGTC_2315 7733312 200 µM -1.33594808919972 0.0879189549458378 no 3074 0.0907831205926299 4292 726316 SGTC_1733 st037357 54.9 µM -1.34003592157531 0.0872501347606878 no 3075 0.0901168333713284 4302 1272339 YGL099W LSG1 SGTC_1285 0929-0069 65.5 µM -1.34216901512969 0.0869026459989534 no 3076 0.0897706002598292 4431 1206237 SGTC_237 nikkomycin 200 µM -1.34459405791522 0.0865088546830791 no 3077 0.0893781816570091 4417 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.34551534282367 0.086359601734769 no 3078 0.089229434972198 4323 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2113 5491891 107.031 µM -1.34616868513382 0.0862538736370642 no 3079 0.0891240608251953 4396 789979 SGTC_2504 purpurogallin 52.29 µM -1.34617199569196 0.0862533381476678 no 3080 0.0891235271185955 4308 5281571 An antioxidant. SGTC_11 0438-0307 1.3 µM -1.35089294889199 0.0854922419004661 no 3081 0.0883648636282452 4385 4011476 SGTC_1638 st008370 60.6 µM -1.35861406518991 0.0842583260855769 no 3082 0.0871344579174902 4341 24207134 SGTC_2680 butyl paraben 22.24 µM -1.35907716170214 0.0841847454860977 no 3083 0.0870610694902715 4503 7184 An antifungal and steroid mimetic. SGTC_949 1165-0505 146 µM -1.36200567655906 0.0837205553767811 no 3084 0.0865980468309684 4391 6244267 SGTC_3331 9141060 1.957 µM -1.36311723426735 0.083544870006775 no 3085 0.0864227830248545 4368 4906567 YPR165W RHO1 SGTC_2715 st079500 56.4 µM -1.36539426893127 0.0831858424131969 no 3086 0.0860645821025654 4400 28246688 SGTC_2488 5268135 45.7 µM -1.36633591887513 0.0830377088973415 no 3087 0.0859167759895914 4442 1270356 YLR208W SEC13 SGTC_3117 9124945 49.47 µM -1.36837400121706 0.0827177721554725 no 3088 0.0855975189834819 4316 17592065 SGTC_2796 7949634 45.45 µM -1.37161032156538 0.0822116441737608 no 3089 0.0850923894709938 4379 2971588 SGTC_205 1486-1330 71.903 µM -1.37192767461065 0.0821621391996392 no 3090 0.0850429770791362 4482 4118834 SGTC_881 0833-0569 170 µM -1.37401748704464 0.0818367029472966 no 3091 0.0847181268085029 4434 5418700 SGTC_1977 st070720 65.3 µM -1.37513135609981 0.0816636429606918 no 3092 0.0845453623834898 4444 682188 SGTC_2189 6047310 154.431 µM -1.37532626044426 0.0816333893800382 no 3093 0.084515159323979 4399 711535 SGTC_3241 9133421 49.47 µM -1.38340915685616 0.0803861690879682 no 3094 0.0832697222132027 4520 17018221 SGTC_925 2064-1272 59.6 µM -1.38435087959266 0.0802417994130855 no 3095 0.0831255208837214 4401 6815817 SGTC_2811 7967822 32.47 µM -1.3860075477252 0.0799883016046157 no 3096 0.0828722993937588 4457 2232244 SGTC_1080 nisoldipine 24.4 µM -1.38827837121063 0.0796418122694819 no 3097 0.0825261478440974 4439 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.38933971894139 0.0794802584368698 no 3098 0.0823647356908136 4420 689007 SGTC_19 0279-0214 38.434 µM -1.39007933981302 0.079367823213667 no 3099 0.0822523931145828 4489 3566274 YBR002C RER2 SGTC_552 k242-0005 476 µM -1.39167398569647 0.0791258189948257 no 3100 0.0820105716765985 4476 4088318 SGTC_671 0560-0003 407 µM -1.3927727337723 0.0789593978882979 no 3101 0.0818442630480885 4361 3238678 SGTC_1665 st014639 11.4 µM -1.39798061625372 0.0781741944360971 no 3102 0.0810594440440391 4515 981133 YIL048W NEO1 SGTC_102 gallobenzophenone 83.616 µM -1.3981434774704 0.078149735356788 no 3103 0.081034993043642 4417 70837 SGTC_625 k213-0058 121 µM -1.40488714407373 0.0771420361984503 no 3104 0.0800274200180549 4500 3655420 SGTC_1821 st053465 65.6 µM -1.40740989557128 0.0767676122563053 no 3105 0.079652939288562 4454 675086 SGTC_2684 capsaicin 100 µM -1.40790172493529 0.0766947767234812 no 3106 0.0795800861312332 4453 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2089 5281248 129.67 µM -1.40803120206571 0.0766756110587142 no 3107 0.0795609154718552 4426 2737878 SGTC_2726 cimetidine 79.27 µM -1.41085279349256 0.0762588530583834 no 3108 0.0791440119794158 4425 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.41238978290135 0.076032561316944 no 3109 0.0789176115854313 4517 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2956 9076196 2.52 µM -1.41293912868454 0.0759518049899633 no 3110 0.0788368114103717 4431 16423868 SGTC_682 0kpi-0099 17 µM -1.41425902606008 0.0757580410691708 no 3111 0.0786429313678621 4448 1714895 YML126C ERG13 SGTC_1649 st011737 51.3 µM -1.41699140318111 0.0753581187441592 no 3112 0.0782427204692904 4473 1761035 SGTC_1361 1608-0041 5.61 µM -1.42110910078483 0.0747584775829823 no 3113 0.0776425223339837 4433 X1361 SGTC_1117 retinoic acid 1.10837 µM -1.42135648277073 0.074722568763249 no 3114 0.0776065754002214 4484 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2797 7859098 81.82 µM -1.42376584101469 0.0743735255338912 no 3115 0.0772571335084079 4413 972681 SGTC_1742 st038235 28.8875 µM -1.42853205998176 0.0736867134098485 no 3116 0.0765693867880829 4484 564103 YBR002C RER2 SGTC_2423 st077119 87.2 µM -1.44060058552892 0.0719693264442064 no 3117 0.0748487774588294 4380 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2187 6125751 200 µM -1.45181825870897 0.0704006963343951 no 3118 0.0732760728145155 4487 874498 SGTC_1905 st060207 84.5 µM -1.45217652643862 0.070351034413864 no 3119 0.0732262639079968 4461 1948547 SGTC_112 phenothiazine 287.218 µM -1.45508034742146 0.0699495095315533 no 3120 0.0728235095790227 4431 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2184 6075246 200 µM -1.46586978681708 0.068473038521991 no 3121 0.0713418821861327 4457 2267320 SGTC_3334 9142812 21.919 µM -1.46790345497365 0.0681974556832823 no 3122 0.0710652247906947 4476 45283678 SGTC_1314 1222-0010 41.1 µM -1.47209522991327 0.0676321289108028 no 3123 0.0704975817226781 4482 3526027 SGTC_406 estrone 100 µM -1.47349945597068 0.067443558721622 no 3124 0.0703082052150442 4472 5870 A steroid. SGTC_1663 st014140 55.4 µM -1.4745267497883 0.06730586343203 no 3125 0.0701699104388011 4555 4207120 SGTC_399 oxolinic acid 75 µM -1.47655929399458 0.0670340679560741 no 3126 0.0698969050168538 4443 4628 A DNA gyrase inhibitor. SGTC_3163 9099914 49.47 µM -1.47677029860217 0.0670059007457086 no 3127 0.0698686103884143 4568 16268368 SGTC_854 0422-0053 192 µM -1.48035558285094 0.0665286956989739 no 3128 0.0693891885112187 4510 3596728 SGTC_20 0481-0013 4.944 µM -1.48174294206595 0.0663447443185694 no 3129 0.0692043531522314 4528 182045 SGTC_2241 6772625 37.8075 µM -1.48221953499229 0.0662816433434468 no 3130 0.0691409451542212 4288 2285411 SGTC_1969 st069479 40.1 µM -1.48299919240127 0.0661785168073396 no 3131 0.0690373126696388 4479 3895485 SGTC_3222 9128301 49.47 µM -1.48704070172613 0.0656459306335121 no 3132 0.0685020306958088 4450 4911358 SGTC_2651 TUB2.036 5 µM -1.48799767195242 0.065520309927156 no 3133 0.0683757537942727 4392 15992207 YFL037W TUB2 SGTC_837 0091-0265 12.5 µM -1.48919895374385 0.0653628826136541 no 3134 0.0682174931222294 4480 759367 SGTC_1502 4534-4282 27.7 µM -1.4923107436115 0.064956448685111 no 3135 0.0678088507776622 4476 3278949 SGTC_1118 chelidonine 707.474 nM -1.49775598054736 0.0642499642784867 no 3136 0.067098330729112 4484 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1137 ixabepilone 100 µM -1.50099571190894 0.0638324723709448 no 3137 0.0666783353367017 4445 154225 A novel microtubule stabilizer. SGTC_118 0083-0097 135.343 µM -1.5079068512808 0.0629489142113127 no 3138 0.0657891844545526 4478 5207356 SGTC_2614 arthonioic acid 13.39 µM -1.50924804389924 0.0627785578546955 no 3139 0.0656177033444096 4374 6710684 SGTC_73 0327-0325 16.231 µM -1.51143902316844 0.0625010358944332 no 3140 0.0653383166548954 4310 53298 SGTC_2120 5538279 151.968 µM -1.51279237868269 0.0623300906094993 no 3141 0.06516620266795 4479 2058197 SGTC_141 0443-0274 32.331 µM -1.51395489917356 0.0621835414333933 no 3142 0.06501863934116 4444 1627241 SGTC_1840 st055363 71 µM -1.51449188429557 0.0621159390541041 no 3143 0.0649505653219707 4519 676033 SGTC_2560 caryophyllene 100 µM -1.51576969832203 0.0619553024595004 no 3144 0.0647887983261144 4525 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2072 5231554 129 µM -1.52058656958585 0.0613526767002614 no 3145 0.0641818096193018 4570 789545 SGTC_1266 0828-0227 32.9 µM -1.52442698694112 0.0608755013460382 no 3146 0.0637010414594391 4479 3913820 SGTC_752 1896-0090 130 µM -1.52760705498021 0.060482575442525 no 3147 0.0633050645405063 4503 772567 SGTC_432 NS 1619 61.3 µM -1.53053375166176 0.0601227119796281 no 3148 0.0629423328382483 4487 4552 A K+/calcium channel activator. SGTC_902 1120-0002 2.07 µM -1.53254810156577 0.059876005189759 no 3149 0.0626936185792259 4492 3280475 SGTC_2049 5262831 67.185 µM -1.53288820762267 0.0598344291752107 no 3150 0.0626517009491643 4461 763417 SGTC_2994 9053520 71.4286 µM -1.53370394512145 0.0597348021122219 no 3151 0.0625512513916843 4526 4647384 SGTC_2140 5586273 200 µM -1.53842704992525 0.0591605158224802 no 3152 0.0619721162916019 4490 854421 SGTC_724 3910-0327 137 µM -1.53851015166018 0.0591504503143411 no 3153 0.0619619641545669 4534 2885483 SGTC_1109 tnp00067 928.257 nM -1.5408082986034 0.0588726243277432 no 3154 0.061681724567902 4522 676295 SGTC_921 1561-0023 372 µM -1.54169856450789 0.0587652744866724 no 3155 0.0615734304727689 4489 24050882 SGTC_1441 4106-0040 13 µM -1.54245125998724 0.0586746330363615 no 3156 0.0614819866597831 4560 2904180 SGTC_383 2324-0395 7.37 µM -1.54263712947688 0.0586522670777753 no 3157 0.061459422000558 4494 3146421 SGTC_3059 1327-0034 3 µM -1.54724105747662 0.0581004025474786 no 3158 0.0609025644732404 4377 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_456 gingerol 170 µM -1.54771323935304 0.0580440344231271 no 3159 0.060845676556439 4534 442793 A herb. SGTC_1248 0469-0687 58.6 µM -1.55223533161551 0.0575063704290838 no 3160 0.0603029625038634 4478 4017482 SGTC_3221 9128209 49.47 µM -1.55411808550082 0.0572836746865046 no 3161 0.0600781259866362 4544 16460723 SGTC_2017 5132927 60.65 µM -1.5569457221868 0.0569504920457359 no 3162 0.0597416863536305 4504 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1232 0279-0259 161 µM -1.56030614398205 0.0565565173015743 no 3163 0.0593437760870343 4518 1560000 SGTC_782 0083-0095 30.5 µM -1.56508533409692 0.0559999093378192 no 3164 0.0587814509423589 4501 3591729 An indicator and reagent. SGTC_428 3448-4153 16.5 µM -1.5664641673103 0.0558401293226938 no 3165 0.0586199954977565 4484 3834874 SGTC_789 1309-1135 70.6 µM -1.56865564518495 0.0555869199436014 no 3166 0.058364099487406 4512 3092424 SGTC_850 0388-0143 75.9 µM -1.57202612311191 0.0551992555086047 no 3167 0.0579722464966538 4533 67273 SGTC_1039 k821-0043 94 µM -1.57589203465189 0.0547572403596967 no 3168 0.0575253434944583 4518 15992768 SGTC_1003 4049-0218 100 µM -1.57789098067087 0.0545297876565113 no 3169 0.0572953286999153 4544 295161 SGTC_2313 7726885 200 µM -1.58247385579564 0.0540111394288908 no 3170 0.0567707180459207 4543 726423 SGTC_442 cape 100 µM -1.58346162545636 0.0538998657875606 no 3171 0.0566581432754002 4566 5281787 SGTC_1956 st077085 54 µM -1.58555158085829 0.0536650277035273 no 3172 0.0564205336351885 4569 24208685 SGTC_190 3970-0790 3.722 µM -1.58870217057073 0.0533125439132127 no 3173 0.0560638243368064 4507 2832352 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.58922821124466 0.0532538703564808 no 3174 0.0560044397428325 4555 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_888 0916-0002 6.97 µM -1.58975601551943 0.0531950515470835 no 3175 0.0559449059309234 4548 2802138 YIL048W NEO1 SGTC_173 1273-0061 2.693 µM -1.59874780241616 0.0522008931824463 no 3176 0.0549383256963456 4495 2847414 YPL266W DIM1 SGTC_350 k064-0020 19.8 µM -1.60348205827966 0.0516834215755001 no 3177 0.0544141335788534 4541 2790705 SGTC_271 rotenone 740 µM -1.60570764927022 0.0514415695197589 no 3178 0.0541690799101516 4583 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2381 9035592 200 µM -1.61003652362851 0.0509737349653559 no 3179 0.0536949415372146 4560 4749657 SGTC_1864 st057645 30.4 µM -1.61073619223342 0.0508984385916556 no 3180 0.0536186168691397 4583 688666 SGTC_1292 0kpi-0043 232 µM -1.61076752281797 0.050895068954393 no 3181 0.0536152011247138 4565 3333905 SGTC_2995 9067767 71.4286 µM -1.62404295774938 0.0494831882388249 no 3182 0.0521833203496976 4542 11673567 SGTC_906 1165-0455 526 µM -1.62789692611827 0.0490792157697767 no 3183 0.0517733716621058 4546 3252859 SGTC_636 0kpi-0074 126 µM -1.63052283991109 0.0488054799234428 no 3184 0.0514955210100147 4575 616434 SGTC_1839 st053978 48 µM -1.63359641485214 0.0484866294539743 no 3185 0.051171810558852 4583 3788398 SGTC_284 0988-0104 32.6 µM -1.63781809118367 0.0480513934901824 no 3186 0.0507298232514494 4547 4666532 SGTC_1071 trifluoperazine 6.31 µM -1.63914180166472 0.0479155705770447 no 3187 0.0505918655171496 4612 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2118 5526350 200 µM -1.64402078558371 0.0474176012014787 no 3188 0.0500859544790327 4565 743594 SGTC_3131 9127911 49.47 µM -1.65730103093368 0.0460831471100602 no 3189 0.0487293144954041 4565 45595681 SGTC_54 0159-0055 9 µM -1.65846665595836 0.0459674749275343 no 3190 0.0486116561707322 4546 3319099 SGTC_2627 acetyl isogambogic acid 100 µM -1.66133936771132 0.0456833937053569 no 3191 0.048322653829187 4575 6857789 A caspase activator and apoptosis inducer. SGTC_2018 5133068 143 µM -1.6656403815099 0.0452607083316784 no 3192 0.0478925315284979 4546 785362 SGTC_2766 oltipraz 83.91 µM -1.66639236039174 0.0451871311932517 no 3193 0.047817645714348 4543 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2336 9001819 198.65 µM -1.66827618670572 0.0450032312830989 no 3194 0.0476304564524064 4568 2989602 SGTC_2370 9071495 200 µM -1.67914253418729 0.043954182183723 no 3195 0.0465621341847904 4599 21791103 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.68032039915963 0.0438416643494233 no 3196 0.0464474970941279 4526 6708739 YPR165W RHO1 SGTC_1298 1079-1278 263 µM -1.68188914515057 0.0436921677671005 no 3197 0.0462951689748256 4559 2840950 SGTC_1241 0364-0022 50.8 µM -1.68948240957265 0.0429743577129911 no 3198 0.0455635100220016 4589 4563895 SGTC_1236 0330-0013 258 µM -1.69345894394984 0.0426022650862946 no 3199 0.0451840716741923 4611 4617066 SGTC_3047 9092122 49.47 µM -1.69431542149865 0.0425224646346254 no 3200 0.0451026808342926 4567 17173831 SGTC_1334 1486-0610 236 µM -1.69784992731317 0.0421944225373819 no 3201 0.0447680449610428 4640 3742339 SGTC_270 tamoxifen 5.46 µM -1.70613891232929 0.0414331404010227 no 3202 0.0439911095660037 4589 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_564 3555-0129 330 µM -1.71113145590789 0.0409800087032313 no 3203 0.0435284242508548 4521 563260 SGTC_377 3970-0964 33.1 µM -1.71193808836287 0.0409071759610643 no 3204 0.0434540392738557 4584 16481235 SGTC_244 nsc-207895 1.295 µM -1.71514433508386 0.0406187139573439 no 3205 0.0431593837847848 4403 42640 SGTC_3220 9131269 49.47 µM -1.71605404407639 0.0405371699315517 no 3206 0.0430760756663942 4599 17722206 SGTC_1672 st016598 6.51 µM -1.72179062845571 0.0400260133952651 no 3207 0.0425537264274459 4564 4665860 YNL267W PIK1 SGTC_2188 6126565 140.678 µM -1.72873652480722 0.0394141247439457 no 3208 0.0419281305829416 4517 874518 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.73595320895896 0.0387864645414707 no 3209 0.0412860541777845 4598 803109 SGTC_402 epigallocatechin gallate 10 µM -1.74161795160781 0.0382995063921093 no 3210 0.0407876590113749 4579 65064 An antioxidant. SGTC_653 0203-0016 55.2 µM -1.746488338244 0.0378848292664183 no 3211 0.0403630658670563 4655 295302 SGTC_1513 0337-0559 19 µM -1.74901557670711 0.0376711018193184 no 3212 0.0401441634535293 4579 775073 SGTC_579 4491-1009 110 µM -1.75127327176671 0.037481002930931 no 3213 0.0399494247187032 4654 1271041 SGTC_908 3448-7491 47.7 µM -1.75251669765528 0.0373766409382943 no 3214 0.0398425006179746 4601 1203031 SGTC_1675 st018485 24.5 µM -1.755759587006 0.0371055783364705 no 3215 0.0395647337792898 4592 3323024 SGTC_1273 0849-0096 14.1 µM -1.76413469292808 0.036412956627737 no 3216 0.0388546523639533 4622 5286025 SGTC_2295 7971645 200 µM -1.7680416333663 0.0360934908398102 no 3217 0.0385269718913816 4644 2978226 YKL099C UTP11 SGTC_2945 9067681 61.76 µM -1.77106008992769 0.0358482500563436 no 3218 0.0382753548996475 4646 16456930 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.79634626676865 0.0338470010087254 no 3219 0.0362197319374165 4641 15053 SGTC_1913 st060213 96.1 µM -1.79995105425202 0.0335693358169761 no 3220 0.0359341835577064 4596 688959 SGTC_1385 3091-4834 14.1 µM -1.80490515065619 0.0331907992716426 no 3221 0.0355447628368107 4620 4072814 SGTC_1037 k284-1091 78.7 µM -1.80919134467261 0.0328661398779488 no 3222 0.0352106409160053 4613 3334711 SGTC_1092 toremifene 6.32 µM -1.818267286383 0.0321873157464389 no 3223 0.0345116451160029 4636 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2712 st079126 47.7 µM -1.82395613991762 0.0317677558023014 no 3224 0.0340793516514993 4635 3152970 SGTC_2848 9016370 25.97 µM -1.82751712545162 0.0315074355024625 no 3225 0.0338110268494649 4608 7894410 SGTC_226 1,3-diallylurea 8.28947 mM -1.8325340650628 0.0311436744142441 no 3226 0.0334359456710968 4613 74537 YKL182W FAS1 SGTC_1667 st014849 34.6 µM -1.83841183399426 0.0307219241994842 no 3227 0.0330008713201666 4726 5348460 SGTC_1953 st076800 12.1 µM -1.84236346580314 0.0304410478864955 no 3228 0.0327110010270831 4604 297591 SGTC_2023 5144124 124 µM -1.84387666864377 0.0303340564370823 no 3229 0.0326005580134296 4615 2830192 SGTC_1134 3477-0009 42.5 µM -1.84533870638802 0.030230978803543 no 3230 0.0324941416478202 4634 3973534 SGTC_1075 aripiprazole 15.2 µM -1.85128289000541 0.0298148828724405 no 3231 0.0320644331366534 4692 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2512 diallyl trisulfide 49.23 µM -1.85442034219817 0.0295971822597379 no 3232 0.0318395233766676 4671 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_841 0251-0215 91.2 µM -1.85488797284198 0.0295648476965683 no 3233 0.0318061129098483 4677 3888614 SGTC_1514 1189-1591 158 µM -1.86724049853966 0.0287212858281859 no 3234 0.0309340052184578 4641 767698 YMR146C TIF34 SGTC_1238 0333-0287 48.8 µM -1.87781956793187 0.0280148348633933 no 3235 0.0302029262118467 4672 7226 SGTC_2329 6138490 200 µM -1.8796652805791 0.0278930764596731 no 3236 0.030076855113793 4635 720019 SGTC_1526 st051518 75 µM -1.88062738215923 0.0278297832986053 no 3237 0.0300113121090199 4622 673993 SGTC_2280 7785178 200 µM -1.88392980172903 0.027613438712321 no 3238 0.0297872357336353 4642 2954328 SGTC_1896 st058441 89 µM -1.88715767770969 0.0274033340855864 no 3239 0.0295695604151782 4656 688759 SGTC_2502 avocadyne acetate 18.59 µM -1.89409197649962 0.0269564816762377 no 3240 0.0291064012694933 4622 3952079 SGTC_14 0354-0009 295 µM -1.89579555784005 0.0268476369319166 no 3241 0.02899354175342 4730 1713507 SGTC_2725 haloperidol 53.21 µM -1.90750517147487 0.0261093774616478 no 3242 0.0282276010005572 4640 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1253 0550-0034 176 µM -1.90837470888361 0.026055239318231 no 3243 0.0281714016332783 4639 5969915 SGTC_830 4076-0286 57.8 µM -1.91029287406682 0.0259361446605918 no 3244 0.0280477573842121 4697 6866659 SGTC_2131 toluylene red 5.2905 µM -1.92081190732503 0.0252911097394451 no 3245 0.0273777123809506 4623 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3318 9139014 38.6185 µM -1.92472438532947 0.0250546480906636 no 3246 0.0271319240486612 4650 16643984 SGTC_3330 9141424 71.43 µM -1.92670844248311 0.0249354459522598 no 3247 0.0270079875716301 4659 27261020 SGTC_2864 9034755 47.6 µM -1.93239973076177 0.0245961490415345 no 3248 0.0266550936283117 4626 4930451 SGTC_1759 st043059 70 µM -1.93292547522461 0.0245650022000854 no 3249 0.0266226895459914 4680 669426 SGTC_657 3534-0529 86.7 µM -1.93329325797207 0.0245432332154518 no 3250 0.0266000409474768 4679 1049549 SGTC_3158 9100007 49.47 µM -1.93362762393533 0.0245234562160018 no 3251 0.0265794641741205 4672 19297233 SGTC_2097 5376186 200 µM -1.94676834394273 0.0237567375797569 no 3252 0.0257812568781095 4672 742755 SGTC_1191 1487-1166 10.6 µM -1.95132919886553 0.0234953820516306 no 3253 0.0255089488984468 4676 3955771 SGTC_3130 9127414 49.47 µM -1.96463041377413 0.0227469450680134 no 3254 0.0247285146049141 4693 1494646 SGTC_1622 st003707 19.4 µM -1.97135799606945 0.022376111049556 no 3255 0.0243414709830321 4674 10140899 SGTC_991 3996-0057 64.7 µM -1.98050410507077 0.0218801536541152 no 3256 0.0238234562658744 4689 715343 SGTC_2114 5491910 81.25 µM -1.98283799325219 0.0217550932098334 no 3257 0.023692764324578 4685 2849228 SGTC_2138 5575593 77.673 µM -1.98324330294805 0.0217334365077375 no 3258 0.0236701295406053 4692 762213 SGTC_1507 4075-3230 155 µM -1.98625885224655 0.0215728793615028 no 3259 0.023502294525895 4645 659771 SGTC_516 3992-2719 87.3 µM -1.98702223293368 0.0215323939842085 no 3260 0.0234599665575774 4589 5350887 YDR037W KRS1 SGTC_2040 5100729 123 µM -1.98919676196979 0.0214174211407765 no 3261 0.0233397445920917 4701 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_816 0325-0417 81.3 µM -1.99584974412742 0.0210688792600636 no 3262 0.0229751401792513 4685 68101 SGTC_476 mead acid 10 µM -2.00092653658587 0.0208061513427514 no 3263 0.0227001536705567 4736 5312531 An omega 9 fatty acid. SGTC_2001 4023502 57.655 µM -2.00547575299458 0.0205730875062209 no 3264 0.0224561051816042 4659 108941 YCR052W RSC6 SGTC_2166 5933061 31.504 µM -2.00785813968947 0.0204519188370567 no 3265 0.02232918427079 4646 2877375 SGTC_811 0416-0114 265 µM -2.02242436514416 0.0197241563165415 no 3266 0.0215662650197171 4676 6612453 SGTC_2610 ononetin 44.17 µM -2.02495547284032 0.0195999650240252 no 3267 0.0214359683194863 4657 259632 SGTC_1911 st060208 74.3 µM -2.02718809834694 0.0194909708514995 no 3268 0.0213215899251257 4693 688783 SGTC_2365 9042475 200 µM -2.04009544221683 0.0188708914591014 no 3269 0.0206704102979882 4685 6464479 SGTC_1221 2958-7315 257 µM -2.04144246888452 0.018807157080174 no 3270 0.0206034334025878 4710 4562705 SGTC_2191 5911152 200 µM -2.04182207870465 0.0187892290096421 no 3271 0.0205845916695664 4699 2875902 SGTC_1063 disulfiram 1.84 µM -2.04653363839279 0.0185679208759497 no 3272 0.0203519481962178 4702 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_225 nsc-122657 1.016 µM -2.06336701873557 0.0177952751756615 no 3273 0.0195388855112844 4713 275685 SGTC_475 α-linolenic acid 10 µM -2.0665950441181 0.0176502874300392 no 3274 0.019386164096006 4698 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2366 9070441 60.58 µM -2.06811956707788 0.0175821642576533 no 3275 0.0193143905838735 4676 6837235 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.07219609505276 0.0174011064132321 no 3276 0.0191235787198362 4693 16623 A steroid. SGTC_2382 9035899 200 µM -2.07384884210782 0.0173281550468063 no 3277 0.0190466757243434 4694 6462679 SGTC_641 4092-0595 30 µM -2.07824389404469 0.0171354296054302 no 3278 0.0188434505704395 4724 786260 SGTC_3114 9122766 49.47 µM -2.07876503912719 0.0171126990491845 no 3279 0.018819475859407 4705 17176985 SGTC_1895 st058434 18.3 µM -2.08443146046637 0.016867208070747 no 3280 0.0185604693149727 4700 5393175 SGTC_680 0417-1641 114 µM -2.09002554274879 0.0166278116217437 no 3281 0.0183077526355346 4722 2835990 SGTC_2860 9025725 38.96 µM -2.09679332002194 0.0163420793433145 no 3282 0.0180059375923211 4728 40546248 SGTC_229 benomyl 22.8748 µM -2.11649221664676 0.0155342157387171 no 3283 0.0171514832412949 4727 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_401 neomycin 50 µM -2.11881406686756 0.0154412922843758 no 3284 0.0170530917341452 4715 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_179 1273-0063 6.77 µM -2.12641041814657 0.0151406036214378 no 3285 0.0167345505270471 4665 3108139 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.13766802879531 0.0147042483783315 no 3286 0.0162718480519443 4691 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1954 st077032 68.9 µM -2.13977239623445 0.0146238926954121 no 3287 0.0161865825236593 4660 698907 SGTC_2997 9067075 71.4286 µM -2.17768664977842 0.0132395548639697 no 3288 0.0147146867513168 4685 27209819 SGTC_1389 3405-0187 19 µM -2.18256184181562 0.0130700394383218 no 3289 0.0145340462104225 4710 799890 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.18882494858624 0.012855020447141 no 3290 0.0143047828331495 4745 16486 A toxic proline analog. SGTC_10 0279-0212 42.575 µM -2.19775470444109 0.0125537465955525 no 3291 0.0139832954403197 4747 39851 YBR002C RER2 SGTC_501 nsc-95397 161 µM -2.20277744346472 0.012386989396166 no 3292 0.0138052193749563 4718 262093 SGTC_750 4073-0104 132 µM -2.20699909657846 0.01224831600647 no 3293 0.0136570612291291 4461 22330957 SGTC_632 0781-2353 4.65 µM -2.20876704873012 0.0121906429421735 no 3294 0.0135954240454576 4743 6811515 YHR007C ERG11 SGTC_18 0111-0177 500 nM -2.21543226424525 0.0119753254531766 no 3295 0.0133652044086431 4765 721752 SGTC_1462 k081-0014 26.5 µM -2.22772336361395 0.0115869048337442 no 3296 0.0129494840175081 4197 3270634 SGTC_485 niflumic acid 177 µM -2.24361602589258 0.0111009188701367 no 3297 0.0124285586197702 4750 4488 A COX2 inhibitor. SGTC_1225 1216-0074 20.6 µM -2.25407625786201 0.010790812818523 no 3298 0.0120956855008111 4734 4241466 SGTC_2552 juarezic acid 87.02 µM -2.27061195968959 0.0103159723974834 no 3299 0.0115852394157067 4721 1549512 SGTC_974 1326-0144 138 µM -2.27626586806737 0.0101578472672361 no 3300 0.0114150508376853 4743 5411856 SGTC_2730 imipramine 71.33 µM -2.27684161087124 0.0101418644823462 no 3301 0.0113978428427072 4721 3696 A tricyclic antidepressant. SGTC_1863 st057641 20.1 µM -2.27762392291225 0.0101201824385183 no 3302 0.0113744969579574 4758 3921635 SGTC_1891 st059073 26.2 µM -2.29230109583157 0.00972083156697828 no 3303 0.0109441373219243 4759 688754 SGTC_648 0375-0473 33.3 µM -2.29589490469185 0.00962517189664423 no 3304 0.0108409455803477 4747 1713139 SGTC_1901 st060216 58.6 µM -2.30188134658211 0.00946765143432262 no 3305 0.0106709322131891 4727 688792 SGTC_266 formosanin C 406 nM -2.30473326685847 0.00939340527634284 no 3306 0.0105907582768488 4629 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1199 1638-0010 4.46 µM -2.30536075306419 0.00937713798412772 no 3307 0.0105731888133556 4740 3111136 SGTC_1204 4049-0315 18.3 µM -2.30606005569266 0.00935903792370341 no 3308 0.010553638429638 4715 588402 SGTC_323 4013-0906 34.3 µM -2.3218184982563 0.00895918816059222 no 3309 0.0101213553858649 4755 2910086 SGTC_2639 lactacystin 53 µM -2.32280074663819 0.00893476793607402 no 3310 0.01009492947864 4736 3870 A proteasome inhibitor. SGTC_2702 st077768 96.8 µM -2.3243901689269 0.00889537594660995 no 3311 0.010052295997242 4723 6484119 SGTC_3097 9117246 49.47 µM -2.33689637915115 0.00859069799441272 no 3312 0.00972228633584151 4753 16423892 SGTC_2784 7567673 72.73 µM -2.34343773833659 0.0084350129881294 no 3313 0.0095534755013249 4687 3471247 SGTC_304 1310-0298 97 µM -2.34509027713025 0.00839607640422338 no 3314 0.00951123653546794 4529 1550234 SGTC_1934 st074720 32.6 µM -2.34937308076657 0.00829589982405723 no 3315 0.00940252697258585 4691 17250992 SGTC_2787 5284540 71.43 µM -2.40298798721553 0.00712785513219783 no 3316 0.00813086080877483 4749 736958 SGTC_1951 sophoraflavanone G 9.2 µM -2.41799525511863 0.00682805304019723 no 3317 0.00780314015852048 4704 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_74 000s-0487 160.283 µM -2.42315755872354 0.00672753048878172 no 3318 0.00769312589943686 4684 677548 SGTC_2464 5717415 7.67 µM -2.42677888181218 0.00665779721707589 no 3319 0.00761676861534663 4731 5285744 SGTC_387 norethindrone acetate 66.7 µM -2.4302669918502 0.00659123402553527 no 3320 0.00754385193279004 4756 541197 SGTC_1030 k029-0042 36.7 µM -2.43067622279767 0.00658346341589355 no 3321 0.00753533765031603 4739 6080581 SGTC_3274 9138298 49.47 µM -2.48318047460275 0.00565125457410671 no 3322 0.00651075484154688 4738 17015756 SGTC_2440 5628896 157.78 µM -2.49100749203718 0.00552282155425091 no 3323 0.00636907168624209 4753 5522048 SGTC_513 4245-1575 41.7 µM -2.50440099479358 0.00530905456412492 no 3324 0.00613294643811408 4633 719745 SGTC_2109 5483026 200 µM -2.51880674150463 0.00508737467231644 no 3325 0.00588766338738781 4771 759335 SGTC_1761 st044296 37 µM -2.52231923109812 0.0050345890531084 no 3326 0.0058291926925557 4771 1826700 SGTC_367 0335-0881 7.1 µM -2.52969712490698 0.00492529963962911 no 3327 0.00570805128776199 4705 23828853 SGTC_849 0386-0493 241 µM -2.57185944719751 0.00434035497122165 no 3328 0.00505769744636607 4770 726119 SGTC_1233 0325-0408 14.2 µM -2.57386640074166 0.00431412764552001 no 3329 0.00502845492682535 4780 12874 SGTC_1904 st060225 78 µM -2.57735051158172 0.00426893276211511 no 3330 0.00497804676978249 4759 66595 SGTC_1711 st032263 62.8 µM -2.61129623903427 0.00385026441479446 no 3331 0.00450998608180207 4779 3958979 SGTC_2461 5755302 26.15 µM -2.6259923447641 0.00368071606399766 no 3332 0.00431983802159989 4766 2788904 SGTC_2293 7624732 200 µM -2.65592665521142 0.00335592858806889 no 3333 0.00395454070657112 4722 894453 SGTC_2057 5236571 38.335 µM -2.68322707517073 0.00308243133091615 no 3334 0.00364577314759387 4739 54684039 YBR257W POP4 SGTC_2144 5628481 200 µM -2.69310973461617 0.00298848527763055 no 3335 0.00353944829586697 4785 2818399 SGTC_2467 5474540 200 µM -2.72277887820352 0.00272174440601504 no 3336 0.00323676852444097 4769 5413519 SGTC_2460 5552655 174.22 µM -2.74152312848475 0.00256450066593045 no 3337 0.00305775275805717 4757 5401989 SGTC_1051 3253-3903 78 µM -2.75697672133228 0.00244108844878308 no 3338 0.00291692522781656 4775 5509239 SGTC_690 glyoxal 20.3 µM -2.77520198372398 0.00230246205267507 no 3339 0.00275837168943778 4675 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1121 fusaric acid 630.51 nM -2.82809928734562 0.00193954062361714 no 3340 0.00234126407088607 4767 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1193 1488-0126 41.5 µM -2.84853805983301 0.00181383260691556 no 3341 0.00219602998586349 4776 1384710 SGTC_235 0330-0087 5 mM -2.86147665433685 0.00173813216989469 no 3342 0.00210836278929908 4794 46494818 YHR062C RPP1 SGTC_3138 9097216 49.47 µM -2.87046147027815 0.00168726818701109 no 3343 0.00204936572341792 4749 25237486 SGTC_1239 0337-0584 35.4 µM -2.88902916918746 0.00158642399361964 no 3344 0.00193216613041359 4790 914301 YML130C ERO1 SGTC_828 2074-0507 139 µM -2.9257523868531 0.00140297900510737 no 3345 0.00171812159732547 4795 X828 SGTC_1006 4099-6547 255 µM -2.93912045846329 0.00134116195976778 no 3346 0.00164572561608007 4792 3146833 SGTC_2059 5238311 157 µM -3.04082042406938 0.000946455194150093 yes 3347 0.00117967249889697 4780 703021 SGTC_2475 5812728 15.03 µM -3.13092107882461 0.000689104795936698 yes 3348 0.000871294916923306 4776 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2856 9022925 19.48 µM -3.27064979717315 0.000414632057405183 yes 3349 0.000536503485362263 4782 4944862 SGTC_1002 4049-0206 172 µM -3.27804829232686 0.000403410101609949 yes 3350 0.000522637556002747 4798 4662749 SGTC_666 0272-0154 136 µM -3.28506026754183 0.000393035163036339 yes 3351 0.000509802798194877 4798 6870312 SGTC_21 0849-0113 22.993 µM -3.39120103034385 0.000263364564289805 yes 3352 0.000347935192341174 4806 1560156 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -3.56576458607158 0.00013304305258262 yes 3353 0.000181398465566353 4792 6708514 SGTC_2148 5546263 113.568 µM -3.61043651322656 0.000111166522730683 yes 3354 0.000152841059766587 4802 792097 SGTC_3211 9128781 49.47 µM -3.72257835848981 7.01932996632159e-05 yes 3355 9.85993402892791e-05 4772 17194361 SGTC_3159 9100096 49.47 µM -4.78441603309401 4.8111307934018e-07 yes 3356 8.57425825489012e-07 4807 25236875