SGTCid condition conc unit TOS6|YNL300W.score TOS6|YNL300W.strain.pval TOS6|YNL300W.strain.significant TOS6|YNL300W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_495 decylubiquinone 155 µM 6.8600927251821 1.5579902035429e-10 yes 1 3.4407932748928e-12 3 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2556 citropten 84.59 µM 6.08973690455191 1.15634036626647e-08 yes 2 5.65481961837238e-10 3 2775 A potential DNA crosslinker. SGTC_517 1365-0151 113 µM 5.99242499971784 1.92469562652634e-08 yes 3 1.03367394514341e-09 11 768657 SGTC_2163 5671233 125 µM 5.35586066574961 4.4578339756297e-07 yes 4 4.2575055029768e-08 7 701023 SGTC_2149 5554786 194.827 µM 5.32485934566695 5.15149779396488e-07 yes 5 5.05155930840645e-08 12 745063 YPR165W RHO1 SGTC_1040 k898-0338 155 µM 5.14163074846557 1.19191914611103e-06 yes 6 1.36182004696849e-07 7 20969351 SGTC_1107 amlodipine 47 µM 4.83573655759916 4.55152811995667e-06 yes 7 6.63267560595687e-07 18 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2792 7535235 81.82 µM 4.68606091036561 8.52974112111743e-06 yes 8 1.39256703407842e-06 21 1281891 SGTC_2801 7907800 81.82 µM 4.60103208189326 1.20894954774002e-05 yes 9 2.10201331980427e-06 18 6620925 SGTC_379 3970-0972 5.9 µM 4.53498927955995 1.57876055601637e-05 yes 10 2.8803205678453e-06 21 2898042 YBL034C STU1 SGTC_2165 5727197 32.143 µM 4.50717496217849 1.76472175257147e-05 yes 11 3.28482298117636e-06 25 1361712 SGTC_51 1013-0126 23.419 µM 4.48076050321199 1.96043564997696e-05 yes 12 3.71887680952338e-06 23 1627850 SGTC_174 3553-0389 74.3 µM 4.42187923522898 2.4734098279724e-05 yes 13 4.89230716300957e-06 14 738071 SGTC_462 ag-879 158 µM 4.37563098800147 2.96302665031365e-05 yes 14 6.05408519045773e-06 20 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2307 7538926 6.34 µM 4.31152484428797 3.79518059283382e-05 yes 15 8.1066276458597e-06 27 96582 SGTC_740 k014-0057 261 µM 4.26479251196528 4.53623737336266e-05 yes 16 1.00044027090992e-05 18 4012779 SGTC_1861 st057647 17.4 µM 4.22719083150099 5.22966134121354e-05 yes 17 1.18313487717878e-05 15 688668 SGTC_981 1488-1094 54.9 µM 4.20593349224153 5.66475680138755e-05 yes 18 1.30003346741766e-05 16 3449522 SGTC_744 1594-0068 283 µM 4.19997855767826 5.79263308996748e-05 yes 19 1.33470129490422e-05 22 668392 SGTC_2475 5812728 15.03 µM 4.07523076787915 9.18633944456596e-05 yes 20 2.29843692895717e-05 19 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2001 4023502 57.655 µM 3.93984784814934 0.000149413628972228 yes 21 4.0766651584285e-05 18 108941 YCR052W RSC6 SGTC_1247 0448-0043 5.84 µM 3.90920404465732 0.000166466782664792 yes 22 4.63003626821153e-05 45 3089013 YGL099W LSG1 SGTC_3344 9148862 3.898 µM 3.8517352257153 0.000203460552578164 yes 23 5.86418980937731e-05 12 4905352 SGTC_1056 3448-1962 115 µM 3.82877838661954 0.000220280848494251 yes 24 6.43904519837692e-05 25 715507 SGTC_3020 9089140 49.47 µM 3.76396639391623 0.000275035671568854 yes 25 8.36196843398217e-05 32 17217859 SGTC_3067 9117431 49.47 µM 3.73322213934911 0.000305223693504347 yes 26 9.45228627926837e-05 17 17150885 SGTC_2137 5261020 140 µM 3.69834662906756 0.000343188060743753 yes 27 0.000108504205104829 45 763655 SGTC_538 2922-0838 53.3 µM 3.63430335959496 0.00042456164149734 yes 28 0.000139366374553804 42 777039 SGTC_503 tyrphostin 8 294 µM 3.61147836027675 0.000457652012292228 yes 29 0.000152228246104969 44 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1436 4092-1007 8.32 µM 3.59918660781785 0.000476446757670173 yes 30 0.000159607035769829 20 2881121 SGTC_872 0588-0139 234 µM 3.59585370366627 0.000481664775110901 yes 31 0.000161664739525038 42 2047100 SGTC_2526 patulin 37.61 µM 3.59114912665637 0.000489120417036655 yes 32 0.000164611591250073 112 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_631 k072-0230 41.5 µM 3.57517336987455 0.000515243187393053 yes 33 0.000174997944408569 26 5773147 SGTC_250 brefeldin a 552.239 µM 3.57463748071833 0.00051614142691008 yes 34 0.000175356746094297 22 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_481 bay k-8644 50 µM 3.55642716987065 0.000547540152683055 yes 35 0.000187966317520368 31 2303 A calcium channel antagonist. SGTC_1464 k208-0027 110 µM 3.55035799780806 0.000558391181940825 yes 36 0.000192353807741918 36 X1464 SGTC_232 clozapine 119 µM 3.47424257747971 0.000712449912295743 yes 37 0.000256148831909153 84 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1417 3966-0327 90.4 µM 3.46429511992879 0.000735253647837185 yes 38 0.000265811463857198 28 651118 SGTC_1264 0783-0040 158 µM 3.44345781517259 0.000785217150884527 yes 39 0.000287163092304338 46 2855798 SGTC_764 1951-2361 146 µM 3.44134058231743 0.000790465024277908 yes 40 0.000289419722484202 57 5438930 SGTC_2970 9090938 41.86 µM 3.43116871530691 0.000816130651243469 yes 41 0.000300493346952066 69 17217104 SGTC_1853 st056710 91.2 µM 3.40007771063597 0.000899409037930652 yes 42 0.000336833521790837 48 269167 SGTC_1239 0337-0584 35.4 µM 3.39888564506375 0.000902752289582611 yes 43 0.000338304999454355 81 914301 YML130C ERO1 SGTC_2558 carylophyllene oxide 100 µM 3.39430723656864 0.000915699285481545 yes 44 0.000344012286032275 32 6708694 An oxygenated terpenoid and antifungal agent. SGTC_578 3460-0051 92 µM 3.35126322598715 0.00104603386764132 no 45 0.00040221898918725 28 2876744 SGTC_867 0518-0118 155 µM 3.33564790378851 0.00109737700266319 no 46 0.000425504358209658 43 6848158 SGTC_2809 7964133 12.99 µM 3.33341321500764 0.00110491071302543 no 47 0.00042893714976939 70 1253665 SGTC_615 k087-0205 167 µM 3.3058130360068 0.0012019477913843 no 48 0.000473506274698068 28 9642773 SGTC_1457 k015-0032 57.3 µM 3.30070593121866 0.00122073661043875 no 49 0.000482209542593093 67 4302660 SGTC_834 0312-0008 75.7 µM 3.27533648220156 0.00131811573124258 no 50 0.000527680951594154 66 6385573 YIL048W NEO1 SGTC_1106 tegaserod maleate 11.7 µM 3.2403722331795 0.00146397443961614 no 51 0.000596868778426271 52 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_175 3793-3120 23.7 µM 3.22359208083857 0.00153908018672983 no 52 0.000632967953322178 42 5322297 SGTC_1261 0712-0010 12.7 µM 3.20588718160788 0.00162212019622178 no 53 0.000673233839145713 55 2840123 SGTC_131 0141-0277 33.849 µM 3.18869394867213 0.00170664714265442 no 54 0.000714585505945323 78 1547771 SGTC_1154 4088-0362 150 µM 3.14175539594124 0.00195822159253408 no 55 0.00083969135598614 64 6618304 SGTC_2652 actinonin 100 µM 3.12743074788703 0.0020414478167132 no 56 0.000881706790201768 15 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2452 5863136 48.41 µM 3.12260493469856 0.00207020062501838 no 57 0.00089629095379283 58 2184096 SGTC_2357 9067248 200 µM 3.11275558792792 0.00213002752634319 no 58 0.000926747227965397 55 9150235 SGTC_1444 4112-3581 28 µM 3.10391158547312 0.00218507923096124 no 59 0.000954901966490905 41 2877249 SGTC_3346 9158254 43.5805 µM 3.07237862274519 0.00239202042618096 no 60 0.00106180088705959 61 17639500 SGTC_2365 9042475 200 µM 3.06940582977194 0.00241241719827211 no 61 0.00107242506374516 84 6464479 SGTC_768 0384-0033 77.3 µM 3.05716748262292 0.00249805407112918 no 62 0.00111719696450018 142 3965305 YMR134W ERG29 SGTC_2907 7721985 69.9 µM 3.04287343209134 0.00260154941684192 no 63 0.00117165434768064 77 3267881 SGTC_1380 2291-0730 164 µM 3.02464683201848 0.00273913207081683 no 64 0.00124461805060331 60 2999191 SGTC_17 0960-0276 49.807 µM 3.01848701876352 0.00278709320573314 no 65 0.00127020142538233 88 6821114 SGTC_1913 st060213 96.1 µM 3.01404805447801 0.0028221239681478 no 66 0.00128893485388096 84 688959 SGTC_892 0929-0076 29 µM 2.99208986017891 0.00300132112962842 no 67 0.00138537346315354 100 5751038 SGTC_1103 duloxetine 36.1 µM 2.97294240350922 0.00316587862018943 no 68 0.00147479897496741 78 60835 A selective serotonin reuptake inhibitor. SGTC_1571 st070080 73.4 µM 2.93743470120435 0.00349267092052764 no 69 0.00165469928807464 61 4315245 SGTC_203 k066-0004 30.888 µM 2.93573246332111 0.00350907238902549 no 70 0.00166380589226634 70 6795412 SGTC_3036 9090181 49.47 µM 2.9271703217007 0.00359262422527706 no 71 0.00171030748922472 29 25236586 SGTC_2567 aureobasidin a 60 nM 2.91618734413098 0.00370241172097101 no 72 0.00177168832109962 170 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2627 acetyl isogambogic acid 100 µM 2.87632044867185 0.00412665716850574 no 73 0.00201170511892186 109 6857789 A caspase activator and apoptosis inducer. SGTC_1213 1315-0166 115 µM 2.87399967277027 0.00415264342263811 no 74 0.00202654691498947 80 768401 SGTC_1189 1431-2119 7.28 µM 2.86280466478843 0.00428006421395198 no 75 0.00209954673318085 97 3107275 SGTC_2773 thioridazine 9.09 µM 2.85961419505499 0.00431701238224979 no 76 0.00212078337867899 57 5452 An antipsychotic. SGTC_1116 jasmonic acid  1.58368 µM 2.84210417038709 0.00452491400442051 no 77 0.00224084226126563 76 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1081 sertraline 6 µM 2.81603741447676 0.00485098430499652 no 78 0.00243100020743971 76 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2779 methotrexate 400 µM 2.77451250843169 0.00541379805247571 no 79 0.00276422540204574 87 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_708 3448-5400 146 µM 2.76992758256774 0.00547936827636227 no 80 0.00280343786180534 120 3462195 SGTC_507 nimesulide 162 µM 2.72452854914036 0.00616770781057111 no 81 0.00321966814722582 78 4495 A COX2 inhibitor. SGTC_820 1582-0060 59.9 µM 2.72123147878692 0.00622056007914927 no 82 0.00325196003894212 99 3848840 SGTC_644 1498-1197 63.3 µM 2.71355135658425 0.00634523116910568 no 83 0.00332831246727307 102 6741615 SGTC_731 3966-0296 387 µM 2.70545377656351 0.0064790692006729 no 84 0.00341055702715009 79 660956 SGTC_1295 1013-0063 9.78 µM 2.6948117757444 0.00665875639357218 no 85 0.00352142016398197 89 6826038 SGTC_1866 st057638 64 µM 2.69452511768403 0.00666365686725162 no 86 0.00352445067890757 73 688802 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.693802464316 0.00667602491379458 no 87 0.00353210088056674 124 688664 SGTC_2344 7990960 76.95 µM 2.67533952496153 0.0069989713659156 no 88 0.00373268017132136 90 140813 SGTC_870 0573-2213 57.6 µM 2.67337060934962 0.00703421160545299 no 89 0.00375466193459071 75 3916321 SGTC_1155 4088-0394 48.2 µM 2.66542411247711 0.00717803684549263 no 90 0.0038445641796862 97 2326248 SGTC_859 0439-0102 54.6 µM 2.64440714898126 0.00757100146386399 no 91 0.00409170775810336 91 610143 SGTC_3221 9128209 49.47 µM 2.6404619451201 0.00764684312749546 no 92 0.00413965451129324 88 16460723 SGTC_1194 1488-0194 225 µM 2.63762838484134 0.00770172675919161 no 93 0.0041744008088007 116 1391452 SGTC_2395 5646831 180.19 µM 2.63074597565976 0.00783647930862292 no 94 0.00425988454852518 111 6808628 SGTC_2966 9084041 48.03 µM 2.61533591029674 0.00814574200264916 no 95 0.00445698705376531 122 17741380 SGTC_2922 7999257 32.47 µM 2.59825528865728 0.00850101538980703 no 96 0.00468494020435042 69 2988377 SGTC_2560 caryophyllene 100 µM 2.59545407475854 0.00856055993003852 no 97 0.00472330132114867 103 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_972 1319-0219 195 µM 2.59095991476938 0.00865685547473326 no 98 0.004785431949553 109 23903702 SGTC_2134 5324836 1.464 µM 2.59056954590655 0.00866526450750646 no 99 0.00479086294615481 83 699272 SGTC_2864 9034755 47.6 µM 2.52616682743579 0.0101544808990915 no 100 0.00576573539188551 99 4930451 SGTC_2725 haloperidol 53.21 µM 2.52436437624193 0.0101991903180156 no 101 0.0057953859754382 142 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2525 harmine 47.85 µM 2.52063520308537 0.0102922370920474 no 102 0.00585716128692635 71 5280953 A monoamine oxidase inhibitor SGTC_2398 5228213 48.84 µM 2.48167710750864 0.0113093948915008 no 103 0.00653828544400123 166 80771 YMR134W ERG29 SGTC_3088 9117578 49.47 µM 2.47974922024666 0.0113619233602841 no 104 0.00657374076582315 72 678341 SGTC_2684 capsaicin 100 µM 2.47904077127147 0.0113812794189737 no 105 0.00658681233840546 98 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_926 2268-1401 59.4 µM 2.47607284508084 0.011462680088802 no 106 0.00664182361644056 120 2931578 SGTC_2015 5119600 184 µM 2.47491547527375 0.0114945598106607 no 107 0.00666338559229783 134 2828786 SGTC_1045 1348-1485 165 µM 2.47416399117954 0.011515300631406 no 108 0.0066774189639878 163 6810614 SGTC_618 k072-0232 33.2 µM 2.47278958960488 0.0115533179528826 no 109 0.00670315241780224 89 5872756 YGL099W LSG1 SGTC_483 fpl-64176 144 µM 2.46519090456957 0.0117654783195788 no 110 0.00684701345240897 66 3423 SGTC_1885 st057546 99.9 µM 2.46342456285784 0.0118152773381606 no 111 0.00688084256260496 124 702008 SGTC_726 3448-4391 34.2 µM 2.4598536426578 0.0119165122635118 no 112 0.0069496842318761 125 1356692 SGTC_1062 mesoridazine 14.2 µM 2.45056546263707 0.0121833613086737 no 113 0.00713160121967367 114 4078 A neuroleptic. SGTC_2098 5376439 882.5 nM 2.44344254876324 0.0123914964766887 no 114 0.00727394283094224 107 2844116 SGTC_1826 st055655 41.6 µM 2.43551788016975 0.0126266718828403 no 115 0.00743524482439255 145 676168 SGTC_717 1532-0246 73.2 µM 2.42976116589412 0.0127999236560784 no 116 0.00755438763770933 145 9561992 SGTC_1012 4112-3522 18 µM 2.42677269688594 0.0128906715778956 no 117 0.00761689845645504 119 3112398 SGTC_75 0159-0059 199.013 µM 2.41909625761717 0.0131263288444027 no 118 0.00777956116218522 127 5377270 SGTC_516 3992-2719 87.3 µM 2.4172607269793 0.0131832258347896 no 119 0.00781890571088688 119 5350887 YDR037W KRS1 SGTC_1445 4239-0156 97.7 µM 2.41334962352843 0.0133051717119269 no 120 0.00790332448580304 138 4008346 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.40730112318103 0.0134956786622567 no 121 0.00803545632943495 217 6708739 YPR165W RHO1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.40511696969162 0.0135650483407888 no 122 0.00808364505309537 132 75037 A free radical scavenger. SGTC_595 3909-8003 73.7 µM 2.4050499378419 0.0135671821603728 no 123 0.0080851279775683 120 699517 SGTC_748 act1.228 77.9 µM 2.40259983141586 0.01364537526966 no 124 0.00813949525014656 208 4421505 YNR035C ARC35 SGTC_1058 3448-5425 97.3 µM 2.39133844457733 0.014009794037868 no 125 0.00839353508300022 144 7279705 SGTC_1573 oleylamine 1.06 µM 2.39083417151788 0.0140263067245127 no 126 0.00840507177490357 157 5356789 An amine of the fatty acid oleic acid. SGTC_1980 st071811 45.7 µM 2.37671547659559 0.0144954891653402 no 127 0.008733777937848 123 4974850 SGTC_2198 6589944 200 µM 2.37474360609584 0.0145620802651466 no 128 0.00878057192223334 91 5290268 SGTC_1625 st003711 30.1 µM 2.36320673228498 0.014956985995974 no 129 0.00905877990431629 147 24207034 YER133W GLC7 SGTC_126 0417-1624 672.48 µM 2.35977864372799 0.0150760890410509 no 130 0.00914292124086408 179 41912 YDL195W SEC31 SGTC_3331 9141060 1.957 µM 2.35855474292421 0.0151188083606259 no 131 0.00917312681330977 133 4906567 YPR165W RHO1 SGTC_1160 4092-0570 10.5 µM 2.35737243268346 0.0151601747224305 no 132 0.00920238885662557 162 4994975 SGTC_762 1165-0429 115 µM 2.33522831350254 0.0159531040206992 no 133 0.0097657483917905 136 5967793 SGTC_1085 doxorubicin 7.67 µM 2.33403598951977 0.0159967888801764 no 134 0.00979691875347456 154 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1293 1000-1278 195 µM 2.33282031959617 0.0160414346282013 no 135 0.00982878887193851 151 678847 SGTC_1863 st057641 20.1 µM 2.33035751083981 0.0161322092348444 no 136 0.00989363173824091 139 3921635 SGTC_2436 5633522 8.09 µM 2.32128911362452 0.0164702575913921 no 137 0.0101356226935055 152 5724242 SGTC_1164 k060-0068 93.7 µM 2.31045861707589 0.0168819224254379 no 138 0.0104313885453428 172 5963676 SGTC_2682 pyrogallin 40.03 µM 2.30516043996986 0.0170864894993541 no 139 0.0105787947708984 178 822798 An ATP competetive kinase inhibitor. SGTC_1721 st082152 9.2685 µM 2.29226356996554 0.0175933221830047 no 140 0.010945219323651 150 5296051 SGTC_3355 9151058 44.0485 µM 2.28820437449267 0.0177554759685159 no 141 0.0110628110443868 123 17015728 SGTC_1238 0333-0287 48.8 µM 2.28298120769356 0.0179660017695431 no 142 0.0112157376689477 163 7226 SGTC_2335 9018011 154.17 µM 2.2811653927155 0.0180396872063658 no 143 0.0112693308821539 168 6458208 SGTC_2354 9060492 162 µM 2.27565045934085 0.0182650637246454 no 144 0.0114334693340023 160 6471895 SGTC_1165 k072-0275 30.3 µM 2.26232038949011 0.0188197458807154 no 145 0.0118388077870045 162 6153523 YGL055W OLE1 SGTC_982 1491-0518 27.5 µM 2.25866898297458 0.0189741635068338 no 146 0.0119519916220667 138 3091256 SGTC_3217 9129673 49.47 µM 2.25588214805198 0.0190927423810243 no 147 0.0120390064114585 190 17248312 SGTC_1014 4130-3005 69.3 µM 2.2520435819332 0.0192571032753425 no 148 0.0121597590136795 178 743608 SGTC_246 cycloheximide 667 µM 2.24900247583366 0.0193881706084582 no 149 0.0122561692766367 116 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3154 9100113 49.47 µM 2.23986168768766 0.0197866971648717 no 150 0.0125499517858959 165 25237525 SGTC_1638 st008370 60.6 µM 2.23655301132805 0.0199326549857745 no 151 0.012657784461209 183 24207134 SGTC_1378 2093-0007 380 nM 2.2351370377781 0.0199953973276186 no 152 0.0127041767339047 178 3618014 SGTC_1555 citronellol 128 µM 2.23396102637787 0.0200476341377251 no 153 0.0127428187749878 85 8842 A terpine precursor. SGTC_1395 3486-0190 4.35 µM 2.22765584536526 0.0203296797205762 no 154 0.0129517367837295 155 6748079 SGTC_3120 9124077 49.47 µM 2.19467295575568 0.0218604807795718 no 155 0.0140935330204231 128 18774327 YGL155W CDC43 SGTC_2649 anisomycin 9.56 µM 2.19257022127232 0.0219612888880082 no 156 0.0141691792988099 106 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2814 7977482 42.97 µM 2.1841906345883 0.0223669255215761 no 157 0.0144741214145711 247 6456762 SGTC_728 3030-5151 22.5 µM 2.18302546044637 0.0224238263125582 no 158 0.0145169675503266 141 3125388 SGTC_3238 9133470 49.47 µM 2.18096265211557 0.0225248620861616 no 159 0.0145930895036774 123 3534688 SGTC_1981 st071826 47 µM 2.17930532300855 0.0226063154418626 no 160 0.0146544970301327 132 11838600 SGTC_1073 triclabendazole 3.09 µM 2.17659969669952 0.0227398233715759 no 161 0.0147552239149131 218 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3066 9117245 49.47 µM 2.17571236646319 0.0227837527306252 no 162 0.0147883874613073 163 17176980 SGTC_3220 9131269 49.47 µM 2.16770473402679 0.0231834335447144 no 163 0.015090579529504 117 17722206 SGTC_697 0508-1955 564 µM 2.16409125646668 0.0233657147926692 no 164 0.0152286732118931 207 6243113 SGTC_2762 leflunomide 42.06 µM 2.16390324296778 0.0233752320179883 no 165 0.0152358880026213 206 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2296 7971656 126.45 µM 2.16308721530203 0.0234165770736132 no 166 0.0152672361140632 199 666570 SGTC_2086 5274770 176.623 µM 2.16258539788676 0.0234420328182975 no 167 0.0152865411771913 175 689278 SGTC_720 r052-1644 49.9 µM 2.16079770056987 0.0235329068203767 no 168 0.0153554848913194 150 1422863 YOR257W CDC31 SGTC_2697 mebhydrolin 72.4 µM 2.15862841718679 0.0236435757737126 no 169 0.0154395031458201 256 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1177 0983-0204 23.6 µM 2.15815161161829 0.02366795924632 no 170 0.0154580230595112 160 766818 SGTC_55 0767-0285 6.563 µM 2.14984732827256 0.024096036812678 no 171 0.0157836465553428 223 3116166 SGTC_396 dithiazanine 1.25 µM 2.14740952891269 0.0242229311647605 no 172 0.0158803463529921 118 10578 An antihelmenthic. SGTC_2704 st078022 71.1 µM 2.14502847007217 0.0243474133390742 no 173 0.0159752853815123 166 54697681 SGTC_1666 st014829 29 µM 2.14467609266231 0.0243658812397875 no 174 0.0159893768369913 197 3858230 SGTC_1765 st044815 90.4 µM 2.14165179126714 0.0245248673194562 no 175 0.0161107563848169 177 645695 SGTC_490 phenamil 164 µM 2.13095131106324 0.0250943930266751 no 176 0.0165465767746042 98 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_313 3474-0040 5.03 µM 2.13010396140547 0.0251399624935451 no 177 0.0165815156807253 273 1043375 YIL048W NEO1 SGTC_1923 st058458 19.1 µM 2.12874543062807 0.0252131674031202 no 178 0.0166376639610707 233 3534982 SGTC_1500 4488-1866 171 µM 2.12519177636382 0.0254055024844587 no 179 0.0167853069797521 180 2900003 SGTC_2628 lathosterol 100 µM 2.1228751012528 0.0255315488659543 no 180 0.0168821597044269 197 6710616 SGTC_1280 0880-0253 10.1 µM 2.12074260042348 0.0256480370972987 no 181 0.0169717347165821 192 6836607 SGTC_1783 st039459 87.517 µM 2.1193638943572 0.0257235857204287 no 182 0.0170298628379174 210 729761 SGTC_2769 toremifene 3.73 µM 2.11528586182067 0.0259481397396479 no 183 0.01720279536305 186 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2315 7733312 200 µM 2.11410821235149 0.0260132905336913 no 184 0.0172530129671074 184 726316 SGTC_2047 4141938 200 µM 2.10892052056361 0.0263019190221976 no 185 0.0174757213064439 145 3807862 SGTC_2679 rapamycin 1 nM 2.10067869803184 0.0267659730421335 no 186 0.0178345902481967 362 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2733 amorolfine 100 µM 2.09989197858661 0.0268106243933617 no 187 0.0178691722719416 81 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_263 alizarin 107.927 µM 2.0894313815706 0.0274102647077416 no 188 0.0183344543992464 297 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_140 0062-0056 502.533 µM 2.08504398811161 0.0276650745152833 no 189 0.0185326539126949 222 3758964 SGTC_2089 5281248 129.67 µM 2.08062104374129 0.0279239442222668 no 190 0.0187343030904001 206 2737878 SGTC_3216 9129716 49.47 µM 2.08056975432632 0.0279269579251499 no 191 0.01873665236654 190 8056934 SGTC_1816 st051957 91.6 µM 2.07963783102144 0.0279817637911323 no 192 0.0187793821513427 166 674121 SGTC_3153 9100258 49.47 µM 2.07833884951349 0.0280583055589377 no 193 0.0188390803126971 220 25236848 SGTC_3274 9138298 49.47 µM 2.07630809650474 0.0281783158469274 no 194 0.0189327324802836 188 17015756 SGTC_1018 4259-0013 28.1 µM 2.07032647278858 0.0285342940305376 no 195 0.0192108910755537 188 6801262 SGTC_2799 7812892 81.82 µM 2.06063564098921 0.0291189498512396 no 196 0.0196689069259815 225 20205235 SGTC_1390 3413-2614 145 µM 2.05716005114058 0.0293310452233811 no 197 0.0198354164336704 225 3421432 SGTC_735 3076-0345 636 µM 2.05701241130368 0.029340083169582 no 198 0.0198425160117853 245 2888990 SGTC_1385 3091-4834 14.1 µM 2.0542130622908 0.0295118867002327 no 199 0.0199775373506851 180 4072814 SGTC_1864 st057645 30.4 µM 2.05384979195999 0.0295342426657531 no 200 0.0199951160201144 142 688666 SGTC_1158 4092-0494 91.8 µM 2.05368534527138 0.0295443674761696 no 201 0.0200030779171598 188 1148199 SGTC_1696 st025591 34.7925 µM 2.0510584641182 0.0297064927684284 no 202 0.0201306268044633 235 2787147 SGTC_534 k292-0788 63.4 µM 2.04124512077718 0.030318694006253 no 203 0.0206132344419683 216 4146317 SGTC_93 0109-0045 59.227 µM 2.03475032977999 0.0307295903415501 no 204 0.020938000595151 268 88733 SGTC_3142 9086498 49.47 µM 2.02643379929952 0.0312624613529147 no 205 0.0213601751386332 206 25236367 SGTC_1149 3909-7961 23.3 µM 2.02308207023927 0.0314793689237736 no 206 0.021532343389181 214 735261 SGTC_1473 k844-0725 134 µM 2.02199599114073 0.0315499209893041 no 207 0.0215883830061206 225 54682906 SGTC_487 nimodipine 119 µM 2.01946057183693 0.0317151314678979 no 208 0.021719685688047 117 4497 L-type voltage-gated calcium channels inhibitor SGTC_1336 1486-0901 104 µM 2.00935642706917 0.0323806435613388 no 209 0.0222496738470615 213 5006114 SGTC_2126 5251174 33.877 µM 2.0085178487705 0.0324363907907087 no 210 0.0222941456479339 295 790722 SGTC_2119 5528445 120.635 µM 2.00550381599846 0.0326374125829067 no 211 0.0224546066001697 204 791935 SGTC_2621 lithochol-11-enic acid 100 µM 2.00322184794882 0.0327902915641497 no 212 0.0225767408037757 252 6708711 SGTC_2731 amoxapine 43.43 µM 2.00292904331516 0.0328099504899192 no 213 0.0225924525950087 83 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2687 chenodiol 100 µM 1.9990897206637 0.0330686230611403 no 214 0.0227993235670801 202 5702181 A cholesterol synthesis inhibitor. SGTC_1547 harmine 94.2 µM 1.99673866734509 0.0332278520865055 no 215 0.0229267896508937 295 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1530 rhein 70.4 µM 1.99543804165632 0.0333162101165162 no 216 0.0229975626843228 212 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1120 ficusin 1.78878 µM 1.99382841644368 0.0334258278538842 no 217 0.0230854044934119 222 6199 A DNA cross-linker. SGTC_990 3985-0011 41.3 µM 1.99179729604976 0.0335645736056595 no 218 0.0231966515291349 187 5399565 YGL099W LSG1 SGTC_1700 st030840 7.9285 µM 1.99145356210886 0.0335881008921634 no 219 0.0232155228524898 221 5499307 SGTC_1857 st056007 79.3 µM 1.98752503567767 0.0338579589699752 no 220 0.0234321221766723 165 619834 SGTC_1463 k081-0032 34.1 µM 1.98622601336181 0.0339475827482661 no 221 0.0235041168183327 140 977755 SGTC_3348 9149464 3.537 µM 1.98516465270283 0.034020954233949 no 222 0.0235630777843253 219 1951442 SGTC_1495 4469-0029 237 µM 1.98422984294361 0.0340856852647934 no 223 0.0236151115596686 360 793680 SGTC_416 estradiol valerate 100 µM 1.97655787526322 0.0346207665094771 no 224 0.0240458138535792 222 13791 A steroid. SGTC_3185 9108267 49.47 µM 1.97377915794384 0.034816262054235 no 225 0.0242034298653839 248 4910486 SGTC_3307 9126885 69.2785 µM 1.97170802421762 0.0349625646180092 no 226 0.0243214735513171 265 24824909 SGTC_2377 9073351 62.6 µM 1.96838306963452 0.0351984906738918 no 227 0.0245119892043275 236 7337946 YHR072W ERG7 SGTC_950 1165-0508 94.1 µM 1.96831534362696 0.0352033097915596 no 228 0.0245158827975268 230 6148369 SGTC_967 1306-0166 352 µM 1.96359212850949 0.0355407328428968 no 229 0.0247887054881657 249 4437607 SGTC_1675 st018485 24.5 µM 1.96304230442622 0.0355801835964231 no 230 0.0248206293144026 250 3323024 SGTC_1504 k297-0033 30 µM 1.94994966227676 0.0365302552783147 no 231 0.0255910595306939 197 4388117 SGTC_3352 9151559 45.5865 µM 1.93573548275775 0.0375851085795923 no 232 0.0264500531524933 231 17159339 SGTC_2317 5986382 200 µM 1.92736833958953 0.038217587965854 no 233 0.0269668711761286 212 877883 SGTC_2472 5377652 49.4 µM 1.92371210386692 0.0384966777192988 no 234 0.0271953400103869 300 1610903 SGTC_971 1315-0384 26.7 µM 1.91968417551905 0.0388060603595275 no 235 0.027448902140537 253 6769120 SGTC_3022 9087993 49.47 µM 1.91302156725738 0.0393222543137197 no 236 0.0278726457440251 194 17173644 SGTC_478 N-arachidonylglycine 10 µM 1.91217427333066 0.0393882980880853 no 237 0.0279269223768349 121 5283389 SGTC_1035 k081-0041 55.2 µM 1.90639044745056 0.0398415425391952 no 238 0.0282997835825903 261 731709 SGTC_649 1123-0311 367 µM 1.90230582826837 0.0401641773567643 no 239 0.0285655920912025 317 693629 YIL048W NEO1 SGTC_2664 lyso-paf C-16 73.48 µM 1.89813311531451 0.040495958872791 no 240 0.0288392744151533 249 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_132 0417-1715 25.805 µM 1.8946935997333 0.0407711121813416 no 241 0.0290665030826754 242 6769098 SGTC_1949 st076024 69.1 µM 1.89208323603174 0.0409809461815385 no 242 0.0292399457661298 276 2921930 SGTC_2481 5478948 45.16 µM 1.88782918405314 0.041324784183698 no 243 0.0295244429578645 267 77792 SGTC_3189 9110682 49.47 µM 1.88123725439497 0.0418621990122332 no 244 0.0299698260352634 244 17122418 SGTC_464 bw-b 70c 158 µM 1.87894330959069 0.0420505375835196 no 245 0.0301261171713355 286 5353454 SGTC_3072 9116419 49.47 µM 1.87750521483006 0.0421689580920127 no 246 0.0302244416413993 230 17170162 SGTC_1025 k007-0731 70 µM 1.87110244383375 0.0426994764035799 no 247 0.0306654414673898 247 6256118 SGTC_732 3970-1727 52.7 µM 1.8705616798608 0.0427445288134801 no 248 0.0307029301128682 214 1275699 SGTC_2875 9039966 71.43 µM 1.86788269035232 0.0429682891960332 no 249 0.0308892120612121 195 6463691 SGTC_2956 9076196 2.52 µM 1.86759720865047 0.0429921895187699 no 250 0.0309091179011163 260 16423868 SGTC_2164 5685496 200 µM 1.86446000414651 0.0432555422238297 no 251 0.0311285666031987 243 759046 SGTC_154 3389-1638 511.116 µM 1.85932601055186 0.0436893244556289 no 252 0.03149047115361 248 5238686 SGTC_3023 9089636 49.47 µM 1.85817135485615 0.0437873657088975 no 253 0.0315723422282928 232 17249241 SGTC_1695 st026914 34.495 µM 1.8567269880073 0.0439102559898512 no 254 0.03167500292105 264 3289191 SGTC_1607 st000305 50.6 µM 1.85304863411064 0.044224475940697 no 255 0.0319376940867596 260 5457690 SGTC_343 4130-2827 29.8 µM 1.84546573078408 0.0448779575975279 no 256 0.0324849095532157 286 1118244 SGTC_1480 1070-0044 41.2 µM 1.84295786678811 0.0450957838738833 no 257 0.0326675811867582 272 3124987 SGTC_1621 st003705 32.4 µM 1.84274631677667 0.0451141973812251 no 258 0.0326830290545434 300 24207032 SGTC_2719 novobiocin 32.65 µM 1.84203502574223 0.0451761531811243 no 259 0.0327350133416396 160 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1511 0906-3109 28.5 µM 1.8392841377386 0.0454164092654538 no 260 0.0329367024452562 379 2882180 SGTC_2028 5153890 36.43 µM 1.8384520152296 0.0454892869854586 no 261 0.0329979132248115 270 2830968 YPR165W RHO1 SGTC_1484 3473-2379 286 µM 1.83786410877404 0.0455408328055732 no 262 0.0330412160039659 305 671917 SGTC_1523 st012844 44.7 µM 1.83379233112357 0.0458991239366335 no 263 0.0333424132732757 288 4274103 SGTC_621 3584-0052 32.1 µM 1.83300964233039 0.045968254542271 no 264 0.0334005685780531 280 2273927 SGTC_2923 7992654 58.14 µM 1.82985804473581 0.0462474648629756 no 265 0.0336355842628162 279 2985126 SGTC_89 0302-0250 142.109 µM 1.82838630790822 0.0463783164782841 no 266 0.0337457974117301 295 4203518 YLR208W SEC13 SGTC_1926 methyl fluorone black 53.6 µM 1.81693460544688 0.0474066653811705 no 267 0.0346135635647855 293 72721 Reacts with homocysteine. SGTC_177 1327-0068 8.361 µM 1.81636127445773 0.0474586262442545 no 268 0.0346574857619235 316 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_652 0437-0092 114 µM 1.81382158163087 0.0476893470317478 no 269 0.0348525993819683 241 3091274 SGTC_2251 lansoprazole 556 µM 1.81099690209232 0.0479470119022559 no 270 0.0350706656058342 218 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2674 ligustilide 100 µM 1.80562921211917 0.0484397180945684 no 271 0.035488138266217 221 5319022 A signalling regulator. SGTC_3028 9087778 49.47 µM 1.80344997363607 0.0486409048927752 no 272 0.0356587876590238 248 17217395 SGTC_2749 bexarotene 57.39 µM 1.79667954636923 0.0492702134212739 no 273 0.0361932539441713 321 82146 An retinoic acid receptor inhibitor. SGTC_1505 k297-0037 20.6 µM 1.78044570818383 0.05080563627951 no 274 0.0375015235039231 301 4089396 SGTC_3275 9138069 49.47 µM 1.78032824818756 0.0508168830976755 no 275 0.0375111283751607 244 17617007 SGTC_274 sirtinol 40.1 µM 1.77960205704553 0.0508864600649757 no 276 0.0375705546700535 282 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1845 st056753 3.01 µM 1.77265677895078 0.0515557304688531 no 277 0.038142798535894 324 5375839 SGTC_1770 st043884 66.3 µM 1.77069963682675 0.0517455859994968 no 278 0.0383053314549694 278 670149 SGTC_3170 9103054 49.47 µM 1.76842571297496 0.0519668689000062 no 279 0.038494880552925 260 16432970 SGTC_412 gemfibrozil 100 µM 1.76816488036811 0.0519922993626935 no 280 0.0385166717523725 233 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2630 antimycin a 100 µM 1.76595588353816 0.0522080671360238 no 281 0.0387016252575203 341 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2854 9024559 71.43 µM 1.76410122447033 0.0523897729885713 no 282 0.0388574691845928 315 3163529 SGTC_413 propylparaben 100 µM 1.7638882557484 0.0524106701958219 no 283 0.0388753972620823 265 7175 A pharmaceutical preservative. SGTC_3279 9140807 49.47 µM 1.76369888853892 0.0524292571009436 no 284 0.0388913441807686 263 45595718 SGTC_167 3672-0051 66.205 µM 1.7630537841569 0.0524926151260388 no 285 0.0389457094538675 291 3237971 SGTC_2732 terfenadine 20 µM 1.76211095702058 0.0525853228797364 no 286 0.0390252761958782 226 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_310 1273-0058 1.06 µM 1.75905606990152 0.052886601401056 no 287 0.0392839927432386 595 2734232 SGTC_636 0kpi-0074 126 µM 1.75081227954723 0.0537064544870339 no 288 0.0399891253563564 277 616434 SGTC_1843 st055809 45.5 µM 1.74613632735927 0.0541759375226594 no 289 0.0403936328425267 280 16413835 SGTC_2702 st077768 96.8 µM 1.74181482773658 0.054612714457032 no 290 0.0407704256310076 296 6484119 SGTC_1910 st062352 60.4 µM 1.7412729339881 0.0546676799482384 no 291 0.0408178740826609 341 2245730 SGTC_3050 9093513 49.47 µM 1.73919381113258 0.0548789759640593 no 292 0.0410003388532155 283 25236664 SGTC_166 k072-0058 166.424 µM 1.73721509106174 0.0550806672551076 no 293 0.0411746060831758 334 5846229 SGTC_533 1222-0222 6.71 µM 1.73257171514476 0.0555562670758153 no 294 0.0415859101082083 341 3982874 SGTC_1186 1319-0216 26 µM 1.73250947407342 0.055562664092753 no 295 0.0415914458639964 321 4565136 SGTC_1818 st052136 56.3 µM 1.73196100903581 0.0556190594078689 no 296 0.0416402524645855 342 674169 SGTC_935 2996-0153 430 µM 1.72667092113231 0.0561653290588992 no 297 0.0421133904528645 301 23738523 SGTC_339 3091-4833 71.4 µM 1.71996910795803 0.0568634421340034 no 298 0.0427190285502924 269 3240077 SGTC_2869 9037858 32.47 µM 1.71566013438841 0.0573158957118324 no 299 0.0431121326429238 255 27187042 SGTC_1023 4482-3888 16 µM 1.71422589985831 0.0574671209132493 no 300 0.0432436229863025 304 3303168 SGTC_1940 st075990 51.1 µM 1.71398519439949 0.0574925315467391 no 301 0.0432657225216126 360 1084979 SGTC_2496 diffractaic acid 79.83 µM 1.70795399947307 0.0581321185023366 no 302 0.0438224391369721 337 94870 An apoptosis inducer which activates caspases. SGTC_3122 9126309 49.47 µM 1.70504463472445 0.0584426387365282 no 303 0.0440930500972244 279 17591206 SGTC_864 0469-0573 172 µM 1.69915757790027 0.0590749551711564 no 304 0.0446447485301319 310 689425 SGTC_2009 4012297 12.05 µM 1.69581657355461 0.0594361851243264 no 305 0.0449603113892952 348 45595307 SGTC_113 0099-0221 2.5 µM 1.69579208878161 0.0594388387989735 no 306 0.0449626306227326 311 89219 SGTC_2411 st077133 39.94 µM 1.68970630993535 0.0601013045165157 no 307 0.0455420777448473 390 1403142 YNL221C POP1 SGTC_711 k292-0785 179 µM 1.68960344826391 0.0601125509728133 no 308 0.0455519229027638 329 4146315 SGTC_2683 piperine 63.03 µM 1.68839232678235 0.0602450937764351 no 309 0.0456679712280444 273 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_919 tnp00227 403.569 nM 1.68109368516938 0.061048692140173 no 310 0.0463723593955443 377 1269246 A methoxyflavone. YNL221C POP1 SGTC_975 1335-0046 28.5 µM 1.67906881737708 0.0612731132750288 no 311 0.0465693163032873 368 16486740 SGTC_2438 5259590 200 µM 1.67618843980118 0.0615934627019105 no 312 0.0468506439108847 335 1201127 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.67617705534805 0.0615947314462785 no 313 0.0468517585334372 412 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_444 curcumin 90.4 µM 1.67528664467734 0.0616940268091874 no 314 0.0469390022632605 352 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2202 7226349 200 µM 1.67239365566268 0.0620175052699473 no 315 0.0472233611649618 265 844334 SGTC_3280 9140961 49.47 µM 1.67161228648261 0.0621051003747039 no 316 0.047300400203297 282 4901226 SGTC_1447 4239-0816 81.9 µM 1.67104202813783 0.0621690898838836 no 317 0.0473566883374743 328 1341554 SGTC_367 0335-0881 7.1 µM 1.67002250951856 0.0622836196936747 no 318 0.0474574550800805 385 23828853 SGTC_3059 1327-0034 3 µM 1.66935193621238 0.0623590396520984 no 319 0.0475238265182944 362 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1203 3992-3522 103 µM 1.6672065639157 0.0626008100014768 no 320 0.0477366689983462 366 5322312 SGTC_1307 1187-1599 12.2 µM 1.66082809071607 0.0633239417400455 no 321 0.0483739888618296 325 1538471 SGTC_2263 7948595 193.29 µM 1.65961584729058 0.0634621070916092 no 322 0.0484958791147599 277 2971371 SGTC_1318 1280-3875 124 µM 1.65669142845623 0.0637963832182687 no 323 0.0487909384279007 382 373245 SGTC_581 0958-0271 211 µM 1.64366219252821 0.0653023609968113 no 324 0.0501229998072849 440 4591145 SGTC_1219 1469-0211 33.1 µM 1.64230078396891 0.0654612969748366 no 325 0.0502638423658793 306 6822282 SGTC_2158 5657123 3.6195 µM 1.64116462852677 0.0655941655708426 no 326 0.0503816229976367 302 2858827 SGTC_613 3914-0030 117 µM 1.63882077422584 0.0658689300320641 no 327 0.050625295668967 117 1145395 SGTC_2787 5284540 71.43 µM 1.63567504647097 0.0662390971173467 no 328 0.0509538073324976 350 736958 SGTC_1839 st053978 48 µM 1.63071954138073 0.0668254915825362 no 329 0.0514747556558531 342 3788398 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.62750837205696 0.06720761476931 no 330 0.0518145859848074 416 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2403 6032726 181.2 µM 1.62622448676893 0.0673608666613114 no 331 0.0519509544508127 373 2881040 SGTC_3001 9076041 71.4286 µM 1.62468886557761 0.0675445217864559 no 332 0.0521144355182502 335 16004211 SGTC_3123 9126162 49.47 µM 1.62313965293486 0.0677301942337235 no 333 0.0522797773400431 345 25239884 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.62187396490031 0.0678821788117842 no 334 0.0524151685659914 400 5379071 SGTC_2836 9010338 19.48 µM 1.6203659888086 0.0680636011623664 no 335 0.0525768406846744 348 2994051 SGTC_2992 9074591 71.4286 µM 1.61452087579144 0.0687703571515735 no 336 0.0532072462384976 331 17741321 SGTC_417 st075190 100 µM 1.60942648107909 0.0693909441479671 no 337 0.0537615593795447 374 222757 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.60837407179098 0.0695196820622029 no 338 0.0538766383813955 397 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2539 epi(13)torulosol 80 µM 1.60468844395152 0.0699719835243728 no 339 0.0542811931750398 367 6708597 SGTC_2467 5474540 200 µM 1.60175362515107 0.0703337620658326 no 340 0.0546050508616365 389 5413519 SGTC_1613 st002381 52.1 µM 1.59883837660154 0.070694550428471 no 341 0.0549282597201987 375 551167 SGTC_3243 9134147 49.47 µM 1.59839707476202 0.0707492892396015 no 342 0.0549773176209089 321 24282180 SGTC_2212 7123476 200 µM 1.59683547076527 0.0709432511974573 no 343 0.0551511934680011 264 1085715 SGTC_838 0109-0203 71.4 µM 1.59311582836263 0.0714069013452047 no 344 0.0555671045573273 371 759422 SGTC_2949 9072542 2.23 µM 1.59225916938578 0.0715140118958661 no 345 0.0556632415990996 425 16457352 SGTC_1821 st053465 65.6 µM 1.59173124075268 0.071580081714948 no 346 0.0557225528032394 339 675086 SGTC_3172 9105863 49.47 µM 1.58216581745402 0.0727853139238476 no 347 0.0568058607735339 246 2348785 SGTC_3161 9100388 49.47 µM 1.58040912680811 0.0730083339545466 no 348 0.057006601393777 340 25236368 SGTC_311 1315-0136 58 µM 1.57729070971825 0.073405519232438 no 349 0.0573643245385205 353 6759207 SGTC_639 0833-0042 114 µM 1.5750981213375 0.0736857719542801 no 350 0.0576168988176656 417 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_234 nsc-17383 10.7 µM 1.57438321847611 0.0737773261639886 no 351 0.0576994405560193 444 408974 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.57418004228838 0.0738033618322198 no 352 0.0577229159701419 389 165521 SGTC_666 0272-0154 136 µM 1.57262467822393 0.0740029040183393 no 353 0.0579028749696015 423 6870312 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.56525730794278 0.0749536897555016 no 354 0.0587612945144026 379 803109 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.56421708559809 0.0750886815212757 no 355 0.058883298052716 457 91467 include heat shock SGTC_9 0092-0002 10.449 µM 1.56350058195766 0.0751817714321757 no 356 0.0589674494562819 393 759368 SGTC_2729 fluphenazine 10.66 µM 1.5624311521655 0.0753208780211062 no 357 0.0590932265528754 411 3372 An atypical antipsychotic. SGTC_40 0327-0103 19.753 µM 1.55849574765459 0.0758344674180566 no 358 0.0595578876225282 383 409036 SGTC_1258 0671-0043 57.1 µM 1.55809327034979 0.0758871426294649 no 359 0.0596055698766523 409 4298767 SGTC_1486 3970-0793 4.53 µM 1.55567152351433 0.0762046831253986 no 360 0.0598931106893578 367 2844330 SGTC_1359 1582-0056 520 nM 1.54773262781986 0.0772527276438516 no 361 0.0608433415451581 447 3661189 SGTC_1671 st016596 74.5 µM 1.54733283836964 0.0773057935792981 no 362 0.0608915035645089 423 2829167 SGTC_1817 st052116 64.4 µM 1.54716154200904 0.0773285390236237 no 363 0.0609121484929684 381 4361398 SGTC_1931 st074438 57.1 µM 1.54473988175326 0.0776506413339191 no 364 0.0612045970110666 373 2787313 SGTC_1227 3909-8010 46.6 µM 1.54304502717248 0.0778766772393333 no 365 0.0614099256680156 374 15982272 SGTC_798 1287-0182 476 µM 1.53962439936948 0.078334392903669 no 366 0.0618259672324051 445 1649755 SGTC_552 k242-0005 476 µM 1.53959471474124 0.0783383739254622 no 367 0.0618295872975327 355 4088318 SGTC_2207 7258803 200 µM 1.53394143052925 0.0790993390782207 no 368 0.0625220311513327 344 3666799 SGTC_2945 9067681 61.76 µM 1.53276685948995 0.0792581432262174 no 369 0.0626666544417207 355 16456930 SGTC_178 4092-0806 87.505 µM 1.53012249891958 0.0796165488557087 no 370 0.0629932050766712 523 2169044 SGTC_1388 3346-4487 254 µM 1.52494833270397 0.0803213788588743 no 371 0.0636359925964542 445 3345614 SGTC_202 3594-0513 34.79 µM 1.52223528006667 0.0806928329028282 no 372 0.0639750690437298 352 708429 SGTC_3078 9116413 49.47 µM 1.52115647093106 0.0808408965913971 no 373 0.0641102880079093 375 17177322 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.51995833771469 0.0810055774949596 no 374 0.0642607234606618 435 2333 A French combination drug. SGTC_2144 5628481 200 µM 1.50577519602539 0.0829743025385754 no 375 0.0660624464005226 373 2818399 SGTC_3334 9142812 21.919 µM 1.50405461944294 0.0832155583894783 no 376 0.0662836518530332 417 45283678 SGTC_1135 dihydrocapsaicin 536.708 nM 1.50136463981583 0.0835937983465746 no 377 0.066630637227183 439 107982 A Capsaicinoid. SGTC_7 0192-1582 4.227 µM 1.50078056111164 0.0836760965021075 no 378 0.0667061640415116 514 252616 SGTC_3113 9123498 49.47 µM 1.50024090695252 0.083752189216098 no 379 0.0667760052167386 393 8897275 SGTC_1778 st046819 58.9 µM 1.49930214415256 0.0838846811802477 no 380 0.066897633196081 478 671715 SGTC_3171 9103192 49.47 µM 1.49900053860965 0.0839272815671201 no 381 0.0669367461656159 360 13018434 SGTC_1004 4084-0029 199 µM 1.49853977581092 0.08399239354498 no 382 0.0669965332023206 462 716894 YLR208W SEC13 SGTC_354 2783-3500 4.88 µM 1.49783021774159 0.0840927378092485 no 383 0.0670886838478512 437 6740761 SGTC_3043 9092303 49.47 µM 1.49778563011311 0.0840990463053804 no 384 0.0670944777360927 386 25236084 SGTC_2133 5320837 200 µM 1.49635339437015 0.0843018757260635 no 385 0.0672807938875091 405 2841355 SGTC_423 5-fluorouracil 457 µM 1.49127067578824 0.085024640309714 no 386 0.0679452223031144 442 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2721 ifenprodil 61.44 µM 1.48968872047513 0.0852505400455365 no 387 0.0681530508881945 416 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2190 6049624 200 µM 1.48567396616799 0.0858258564496036 no 388 0.0686826899836934 354 2265554 SGTC_3184 9108758 49.47 µM 1.48461106102759 0.085978656740331 no 389 0.068823441848702 380 902885 SGTC_409 arachidonic acid 100 µM 1.48422571186416 0.0860341037143651 no 390 0.0688745253892487 426 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_659 k018-0002 107 µM 1.48235857728513 0.0863031401794628 no 391 0.0691224548001112 438 6797879 YHR007C ERG11 SGTC_2394 5221648 200 µM 1.48095646279864 0.086505584916551 no 392 0.0693090877372862 492 788586 SGTC_3325 9138760 55.175 µM 1.47888716715268 0.086805009125559 no 393 0.0695852368409804 428 43844959 SGTC_2614 arthonioic acid 13.39 µM 1.47612661674067 0.0872056617071204 no 394 0.0699549523805705 401 6710684 SGTC_371 0195-0006 7.36 µM 1.47601357684333 0.0872220971358321 no 395 0.0699701237616942 364 3928593 SGTC_2896 9052656 71.43 µM 1.47344289173431 0.0875964863599259 no 396 0.0703158260027358 581 6469436 SGTC_3272 9137413 49.47 µM 1.47258457510175 0.0877217564548695 no 397 0.0704315432671719 417 17614870 SGTC_2838 9002687 71.43 µM 1.47081261685218 0.0879807939212216 no 398 0.070670899704453 405 6457060 SGTC_3035 9091303 49.47 µM 1.46851813580293 0.0883170644257363 no 399 0.0709817668190578 385 25237002 SGTC_3057 9095946 49.47 µM 1.46213733445372 0.0892572451740364 no 400 0.0718517898633862 426 24540043 SGTC_840 0245-0196 390 µM 1.45850263313369 0.0897961195545714 no 401 0.0723510249406111 491 3827528 SGTC_1628 st004252 77.7 µM 1.45764800514922 0.0899231756273857 no 402 0.0724687952210727 469 692968 SGTC_2215 7188065 200 µM 1.45608690331311 0.0901556067912881 no 403 0.0726842987634376 364 940217 SGTC_497 capsazepine 133 µM 1.44996730514774 0.0910710532945982 no 404 0.0735338183794774 420 2733484 A calcium channel blocker. SGTC_1631 benzylvanillin 81.9 µM 1.44686259758493 0.0915381223927789 no 405 0.073967705226665 473 75506 SGTC_3016 9080866 49.47 µM 1.44320217984273 0.0920910694474077 no 406 0.0744817628306297 476 17066299 SGTC_121 0557-0495 61.343 µM 1.44287613501822 0.0921404418556295 no 407 0.0745276835003801 624 3104427 SGTC_573 3702-0553 84.7 µM 1.44250976518131 0.0921959439893987 no 408 0.0745793093911258 447 1222756 SGTC_3167 9103034 49.47 µM 1.44236276956008 0.0922182196192114 no 409 0.0746000305029168 352 5127859 SGTC_2066 5222451 176 µM 1.44140634199548 0.0923632533844247 no 410 0.0747349598151483 527 2281147 SGTC_629 3448-6466 76.7 µM 1.43719056991422 0.0930045499916355 no 411 0.0753319258782267 489 573744 SGTC_307 1501-1223 22.3 µM 1.43224139368188 0.0937616039209529 no 412 0.0760373745376869 457 2830329 SGTC_1681 tripelennamine 100 µM 1.4299719022264 0.0941102755644419 no 413 0.0763625417761174 404 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2293 7624732 200 µM 1.42959658995358 0.0941680284481064 no 414 0.0764164174138008 431 894453 SGTC_3228 9131799 49.47 µM 1.422426201697 0.0952764308583884 no 415 0.0774512806029922 452 17015818 SGTC_3005 9076496 71.4286 µM 1.41989730258451 0.0956696319235892 no 416 0.0778187906765295 425 21368410 SGTC_2598 perillyl alcohol 100 µM 1.41957536777018 0.0957197728925062 no 417 0.0778656703849495 467 10819 An apoptosis inducer. SGTC_1653 st012112 65 µM 1.4138398852983 0.0966163104777401 no 418 0.0787044598599203 443 720429 SGTC_954 1189-0853 2.85 µM 1.41270609686931 0.0967942655928572 no 419 0.0788710790888595 485 2828194 SGTC_2274 7947094 46.08 µM 1.41215746798645 0.0968804626568791 no 420 0.0789518003447627 491 2971028 SGTC_3289 9119912 71.43 µM 1.41135553690019 0.097006558322191 no 421 0.0790699032070612 462 17014829 SGTC_2424 5537928 59.2 µM 1.40516100099339 0.0979846490119247 no 422 0.0799867040265627 518 5382802 SGTC_3327 9140648 26.9345 µM 1.40511941199942 0.0979912400693843 no 423 0.0799928863090096 454 8029710 SGTC_3098 9119039 49.47 µM 1.40450373879533 0.0980888504654187 no 424 0.0800844495608957 477 17161528 SGTC_66 0109-0187 42.4 µM 1.40327317402972 0.0982841607889645 no 425 0.0802676972318538 454 759417 SGTC_1190 1486-1332 13 µM 1.39823610673982 0.0990865933762259 no 426 0.0810210887276361 471 4150046 SGTC_3276 9139060 49.47 µM 1.39176329404059 0.100124769373251 no 427 0.0819970442935696 395 4870619 SGTC_1786 berberine 21.6 µM 1.39147406476577 0.100171343582867 no 428 0.0820408594549493 495 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_144 4161-2749 112.381 µM 1.38663149325415 0.100953487001649 no 429 0.0827770799990953 411 797501 YMR168C CEP3 SGTC_2850 9015429 58.44 µM 1.38578909688928 0.101089999233471 no 430 0.0829056563178838 456 6457570 SGTC_148 3253-0744 288.01 µM 1.38442113316568 0.101311967395716 no 431 0.0831147708345563 462 6893655 SGTC_3141 9094609 49.47 µM 1.384227722553 0.101343379166019 no 432 0.0831443686294936 471 25236309 YDL196W YDL196W SGTC_2162 5663267 200 µM 1.38224331412407 0.101666076382167 no 433 0.0834485023561725 508 6456493 SGTC_2841 9004761 38.96 µM 1.38147526869382 0.101791173721452 no 434 0.0835664384410206 441 2991039 SGTC_205 1486-1330 71.903 µM 1.37570105849159 0.102735252123394 no 435 0.084457102056207 427 4118834 SGTC_3134 9127454 49.47 µM 1.37386085435346 0.103037456917116 no 436 0.084742442224759 467 24262820 SGTC_233 rapamycin 362 pM 1.3720755201853 0.103331267385899 no 437 0.0850199646241504 488 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3285 9112818 20.8695 µM 1.37173565145458 0.103387268053414 no 438 0.0850728728306826 548 17017947 YPR165W RHO1 SGTC_1371 2421-0008 32.7 µM 1.36989175986212 0.103691472790393 no 439 0.0853603461623676 513 2827552 SGTC_1462 k081-0014 26.5 µM 1.36796686379174 0.104009733905597 no 440 0.085661224240659 346 3270634 SGTC_1667 st014849 34.6 µM 1.36658196394289 0.104239150118373 no 441 0.0858781868387319 512 5348460 SGTC_2784 7567673 72.73 µM 1.36632237007826 0.104282194046425 no 442 0.0859189013290883 537 3471247 SGTC_641 4092-0595 30 µM 1.36455590744407 0.104575437890027 no 443 0.0861963355525371 523 786260 SGTC_2662 daunorubicin 22.37 µM 1.36395758760938 0.10467489802691 no 444 0.0862904572590233 445 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2247 cerulenin 830 nM 1.36356086149273 0.104740884522545 no 445 0.086352908619492 511 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_125 0133-0007 11.75 µM 1.36267384830885 0.104888528241726 no 446 0.0864926616614532 519 26541 SGTC_2528 xanthyletin 44.79 µM 1.35097926913794 0.106849200661175 no 447 0.0883510367907179 477 65188 An natural product with antifungal activity of unknown mechanism. SGTC_584 0986-0246 15.4 µM 1.33933716900624 0.108827204901902 no 448 0.0902304668494086 569 53315 YDR232W HEM1 SGTC_1382 3002-2117 298 µM 1.33503338657156 0.109565046381605 no 449 0.0909327097752931 538 1497314 SGTC_357 1325-0123 420 µM 1.33335850467647 0.109853157336799 no 450 0.0912070914412782 502 1098503 SGTC_294 k038-0071 157 µM 1.33301087716067 0.109913023836794 no 451 0.0912641171564961 533 24152826 SGTC_2358 9037157 4 µM 1.33185972256105 0.11011143648013 no 452 0.091453144241712 530 2388925 SGTC_1676 st018489 23.4 µM 1.32606017204632 0.111114953497362 no 453 0.0924098835658646 539 3696235 SGTC_2362 9071156 126 µM 1.32499367340472 0.111300204247556 no 454 0.0925866248435857 518 653133 SGTC_400 oxethazaine 37.5 µM 1.32492889153932 0.111311463972269 no 455 0.092597368612774 511 4621 A local anesthetic. SGTC_2618 avocadyne 43.43 µM 1.32436050809008 0.111410289564068 no 456 0.0926916718920747 492 3015189 SGTC_3290 9121031 71.43 µM 1.32432129082615 0.111417110637498 no 457 0.0926981812388795 458 17014854 SGTC_889 0919-1524 82.7 µM 1.31891876062461 0.112359633300719 no 458 0.0935981367295715 494 3905452 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.318701705684 0.112397619276044 no 459 0.0936344281643442 565 688801 SGTC_118 0083-0097 135.343 µM 1.31674957537872 0.112739666705766 no 460 0.0939612900361788 771 5207356 SGTC_2872 9044037 25.97 µM 1.31614207381916 0.112846263106868 no 461 0.0940631808121681 453 6465195 SGTC_2936 9038235 15.59 µM 1.31513625738843 0.113022908723041 no 462 0.0942320565474296 520 4749415 SGTC_782 0083-0095 30.5 µM 1.30593333583546 0.114648331609934 no 463 0.0957876144575955 602 3591729 An indicator and reagent. SGTC_548 1436-0017 110 µM 1.30571766312339 0.114686622254799 no 464 0.0958242945214154 635 9677137 SGTC_952 1185-0122 232 µM 1.30361956512676 0.115059594571275 no 465 0.0961816632123762 540 678600 SGTC_2947 9072639 7.68 µM 1.30163572845732 0.11541304760073 no 466 0.0965204700513879 576 16488146 SGTC_3166 9102297 49.47 µM 1.30105497404768 0.115516664373495 no 467 0.0966198191185504 578 25237072 SGTC_770 0389-1121 67.2 µM 1.30103495386344 0.115520237503677 no 468 0.0966232452900076 596 6753108 SGTC_1027 k015-0025 8.67 µM 1.29660436199468 0.116312926181125 no 469 0.097383675421399 550 3598955 SGTC_493 zm226600 134 µM 1.28905605958623 0.117672286204563 no 470 0.0986892990137527 559 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1683 st010134 710 nM 1.2879790799944 0.117867150403278 no 471 0.0988766227748861 554 3818134 SGTC_3254 9136651 49.47 µM 1.28727496921888 0.117994672639895 no 472 0.0989992323962987 580 16454030 SGTC_2993 9054257 71.4286 µM 1.28686390201254 0.118069166555771 no 473 0.0990708645699405 580 6470217 YGL055W OLE1 SGTC_3146 9095609 49.47 µM 1.28142498247793 0.119057944566375 no 474 0.100022216918988 549 17173999 SGTC_1950 st077106 7.18 µM 1.27962653908574 0.119386178353074 no 475 0.100338255794131 571 13831864 SGTC_309 k408-0051 1.48 µM 1.27703726165183 0.119859867831036 no 476 0.100794546241582 646 3640463 SGTC_2437 5741531 144.16 µM 1.27439881801192 0.120343913373529 no 477 0.101261055507246 598 2262990 SGTC_3283 9109332 35.8195 µM 1.27416430271436 0.120387003794048 no 478 0.101302596700409 473 17027281 SGTC_881 0833-0569 170 µM 1.27271983712196 0.120652653090006 no 479 0.101558737903761 578 5418700 SGTC_2636 apigenin dimethyl ether 100 µM 1.27029432282728 0.12109965323518 no 480 0.10198990484593 597 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1059 3448-6867 171 µM 1.26837845187397 0.121453553339902 no 481 0.102331416475318 565 3934407 SGTC_642 0335-0876 158 µM 1.26564541331771 0.121959658219138 no 482 0.102820029751344 578 6812350 SGTC_256 clotrimazole 625 nM 1.26408008097229 0.122250193175499 no 483 0.103100642636099 561 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_730 1436-0052 41.2 µM 1.26261432617428 0.122522686122682 no 484 0.103363908405247 528 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2405 ticlatone 3.52 µM 1.26257036936469 0.122530864544098 no 485 0.103371811064365 544 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1709 st033179 39.1045 µM 1.26214665028287 0.122609719598671 no 486 0.103448010774628 592 573381 SGTC_1977 st070720 65.3 µM 1.25716971813986 0.123538603206012 no 487 0.104346093015597 520 682188 SGTC_103 0844-0104 51.839 µM 1.25476074974906 0.12398997346925 no 488 0.104782812533346 688 5375804 SGTC_3330 9141424 71.43 µM 1.25271013002587 0.124375107981353 no 489 0.10515560900593 620 27261020 SGTC_1596 piperlongumine 63 µM 1.25220282541638 0.124470515690295 no 490 0.105247983369485 650 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_270 tamoxifen 5.46 µM 1.25172167043408 0.124561052766206 no 491 0.105335650423674 626 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2390 9097792 176.6 µM 1.25143888429621 0.124614285017072 no 492 0.105387199061651 547 4497149 SGTC_756 0508-1999 28.3 µM 1.24926982856817 0.125023121370667 no 493 0.105783199679854 562 6753853 SGTC_809 3998-0021 90 µM 1.24785035405979 0.125291178909187 no 494 0.106042932212387 547 715485 SGTC_3222 9128301 49.47 µM 1.2456203101011 0.125713116550003 no 495 0.106451911152771 585 4911358 SGTC_920 mycophenolic acid 780.421 nM 1.24365101643505 0.126086542017703 no 496 0.106814015637008 591 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2580 diallyl disulphide 81.36 µM 1.24340022140858 0.126134154244597 no 497 0.106860194374453 551 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1766 st045414 44.774 µM 1.24190052042072 0.126419126795344 no 498 0.107136634035038 615 253960 SGTC_2146 5545642 200 µM 1.23585543003411 0.127572359182715 no 499 0.108256153337135 601 825326 SGTC_3135 9127742 49.47 µM 1.23434977280709 0.127860730237861 no 500 0.108536298267013 558 3643468 SGTC_1862 st057513 3.81 µM 1.23388508082364 0.127949821790488 no 501 0.108622864805114 566 5393163 SGTC_2139 5578692 56.4705 µM 1.23310257139378 0.128099943303314 no 502 0.108768749120005 528 650991 YMR113W FOL3 SGTC_895 0964-0006 13.7 µM 1.23160319377056 0.128387935004172 no 503 0.109048673665062 585 6738897 SGTC_2261 9010538 184.68 µM 1.23112116386026 0.128480615902828 no 504 0.109138775563142 508 6457250 SGTC_2070 5230947 200 µM 1.22914343848688 0.128861363394204 no 505 0.109509015573963 617 2835538 SGTC_2178 5812956 200 µM 1.22688352874222 0.129297393698383 no 506 0.109933185087922 571 5403383 SGTC_825 1988-2224 89.6 µM 1.22656998961089 0.12935796908121 no 507 0.109992127233013 637 1180859 SGTC_1717 st033143 58.0435 µM 1.22351109093523 0.129949976585037 no 508 0.110568358865506 651 674616 SGTC_2231 micatex 6.853 µM 1.22328409596258 0.129993982954867 no 509 0.110611205988539 566 20737 An antifungal of unknown mechanism. SGTC_1970 st070122 35.8 µM 1.22276760530901 0.130094150826327 no 510 0.110708742086926 596 102928 SGTC_290 2043-6722 48.1 µM 1.22136951760295 0.130365563031299 no 511 0.110973071573498 604 773758 YLR208W SEC13 SGTC_374 0880-0231 82.3 µM 1.22134600656212 0.130370130600171 no 512 0.110977520550615 611 6833587 SGTC_3191 9110352 49.47 µM 1.22112187109646 0.130413679707865 no 513 0.111019939955827 577 17122424 SGTC_1273 0849-0096 14.1 µM 1.21922596946249 0.130782452427979 no 514 0.111379218918952 602 5286025 SGTC_878 0828-0289 13.7 µM 1.2131472936531 0.131969675942037 no 515 0.112536755512514 655 745350 YLR208W SEC13 SGTC_2136 5328288 199.296 µM 1.21188208348086 0.132217715244462 no 516 0.112778760683729 522 262395 SGTC_252 miconazole 1.30953 nM 1.20853770678107 0.132874913568772 no 517 0.113420250497716 604 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.20583958217626 0.133406754594749 no 518 0.113939675073419 597 6710655 SGTC_199 4063-0024 41.6 µM 1.20556838373822 0.133460292769674 no 519 0.113991977941969 621 306215 SGTC_2276 7947513 42.08 µM 1.20273327655989 0.134020865397179 no 520 0.114539776172932 568 2105100 SGTC_2120 5538279 151.968 µM 1.20245292034667 0.134076386706804 no 521 0.114594048115 615 2058197 SGTC_3299 9121982 43.1275 µM 1.20187002351362 0.13419187326889 no 522 0.114706945079339 620 17594604 YPL160W CDC60 SGTC_2376 9072922 81.32 µM 1.19403146179065 0.135751528697863 no 523 0.116232830665249 643 17087968 SGTC_2484 5809818 12.04 µM 1.18860552560266 0.136838382899674 no 524 0.117297466240898 608 2870548 SGTC_1290 0986-0249 10.2 µM 1.18615737995566 0.137330706131642 no 525 0.117780076953262 571 53329 SGTC_3206 9114350 49.47 µM 1.18572106714231 0.137418575685862 no 526 0.117866236002416 595 17087243 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.18480441226937 0.13760330691933 no 527 0.118047393831632 644 4213774 SGTC_2865 9030313 51.95 µM 1.18435906768235 0.137693117286028 no 528 0.118135478003529 575 42562754 SGTC_2244 6635614 200 µM 1.18358609184955 0.137849094325972 no 529 0.118288474301664 498 836499 SGTC_288 1315-0019 35.1 µM 1.1833945024226 0.137887773356597 no 530 0.118326417547278 654 6811474 SGTC_2085 5307070 144.047 µM 1.18269131681928 0.138029799430607 no 531 0.118465753380444 575 2840351 SGTC_2885 9057732 51.95 µM 1.18231721294409 0.138105399792324 no 532 0.118539929095103 626 6471414 SGTC_2292 7671323 168.05 µM 1.18077998960852 0.138416344203939 no 533 0.11884506766359 628 937504 SGTC_2072 5231554 129 µM 1.17855950173467 0.138866338891833 no 534 0.119286812934834 644 789545 SGTC_1614 st002383 48.6 µM 1.17707719161226 0.139167291486216 no 535 0.119582348893424 652 1947235 SGTC_1231 0242-0792 125 µM 1.17580642371551 0.139425647920815 no 536 0.119836119432451 630 3707635 SGTC_1327 1436-0082 2.18 µM 1.17103095421283 0.140399451460987 no 537 0.120793167567827 630 15992205 SGTC_558 k064-0027 21.3 µM 1.17062698383845 0.140482039579201 no 538 0.120874373051393 651 5088526 SGTC_2882 9058044 58.44 µM 1.16970022374085 0.140671631970306 no 539 0.121060814042579 608 18076804 SGTC_1471 k673-0312 37 µM 1.16615519608553 0.141398459747302 no 540 0.121775851786349 623 24099884 SGTC_672 1441-0018 53.7 µM 1.1651469985811 0.141605631881706 no 541 0.121979747694205 616 251141 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.16396087577825 0.141849628626688 no 542 0.122219933705278 621 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2714 st079313 56.9 µM 1.16324949421817 0.141996103080243 no 543 0.122364145339038 627 2939799 SGTC_3356 9151811 4.48 µM 1.162560916703 0.142137979639003 no 544 0.122503847832211 643 1859254 YPR165W RHO1 SGTC_553 k007-0256 45.7 µM 1.16144565290324 0.142367975384404 no 545 0.122730356206229 656 6287000 SGTC_145 3737-0113 38.366 µM 1.16025996034422 0.142612771306115 no 546 0.122971490542156 751 6849351 SGTC_505 gw-5074 63.9 µM 1.15345234767586 0.144023765030866 no 547 0.124362382914424 665 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2199 6590217 200 µM 1.14729846125204 0.145307338710102 no 548 0.125629144881629 591 703109 SGTC_3060 1327-0027 12.5 µM 1.14655610291701 0.145462697926741 no 549 0.125782563835036 635 16000455 YPR107C YTH1 SGTC_1930 st074634 34.3 µM 1.14504969777843 0.145778298527114 no 550 0.126094285516046 668 684253 YOR116C RPO31 SGTC_2689 tacrolimus 100 µM 1.14481506016838 0.145827497862043 no 551 0.126142887707927 636 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.13929959814674 0.146987206713725 no 552 0.127289107975751 658 6312947 SGTC_1807 st050092 58.9 µM 1.13706983839431 0.147457798130602 no 553 0.127754545756127 654 5008496 SGTC_384 k007-0144 5.16 µM 1.13701797399148 0.14746875612725 no 554 0.12776538593741 723 6824886 SGTC_1763 st044482 94.5 µM 1.13425296794864 0.148053741104709 no 555 0.128344225703655 685 88505 SGTC_2695 st077686 51.995 µM 1.13274116147479 0.14837424581954 no 556 0.128661483363601 636 2876092 SGTC_247 mechlorethamine 29.705 µM 1.13247564178126 0.148430584174289 no 557 0.12871725969356 616 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1124 fisetin 1.16336 µM 1.13081412456575 0.14878345215153 no 558 0.129066666849251 626 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2173 5763948 167 µM 1.1290938651172 0.149149385895627 no 559 0.129429119514197 700 2867177 SGTC_361 000s-0510 1.45 µM 1.12847833666711 0.149280467056243 no 560 0.129558980379138 684 660 SGTC_1957 st077035 62.4 µM 1.1265795998363 0.149685301044915 no 561 0.129960134156544 694 705593 SGTC_2290 7904846 200 µM 1.12637390651119 0.149729201317515 no 562 0.130003643376823 677 2962154 SGTC_120 rhodamine 6G 52.259 µM 1.11916239111492 0.151273754885147 no 563 0.131535433371167 795 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2543 pimpinellin 60.67 µM 1.11872306650869 0.151368190148376 no 564 0.13162915074721 665 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1655 st012546 55.1 µM 1.11779622551173 0.151567548344082 no 565 0.131827016974844 652 720985 YLR208W SEC13 SGTC_2030 5175110 200 µM 1.11720128581884 0.151695608406656 no 566 0.131954135482173 693 2831986 SGTC_1429 4049-0205 9.46 µM 1.11686204014935 0.15176866281781 no 567 0.132026658654828 751 22774478 SGTC_574 1315-0397 40 µM 1.11611221938244 0.151930214911596 no 568 0.132187051151842 786 6794277 SGTC_785 1270-0111 65.3 µM 1.11570100435204 0.152018861437058 no 569 0.132275070261958 680 6741994 SGTC_1366 1683-0113 21.9 µM 1.11376231171154 0.152437252352003 no 570 0.13269058467342 653 708623 SGTC_2171 5739187 198.077 µM 1.11330473113244 0.152536114574759 no 571 0.132788787599849 624 2262761 SGTC_3316 9136639 10.545 µM 1.11104676899961 0.1530245796728 no 572 0.133274109334759 684 4903665 SGTC_2059 5238311 157 µM 1.11019841284475 0.153208372305594 no 573 0.133456768283437 654 703021 SGTC_661 1304-0007 33.6 µM 1.10850166123912 0.15357640477774 no 574 0.133822611043582 687 3117130 SGTC_2813 7971799 71.43 µM 1.10783880776411 0.153720339345818 no 575 0.133965718358018 673 2234054 SGTC_91 0417-1751 58.384 µM 1.10770036304893 0.153750413037308 no 576 0.133995621268536 808 6795624 SGTC_1623 st003709 20.3 µM 1.10486603517547 0.154366956744026 no 577 0.134608820804216 760 16192618 SGTC_2469 5655019 90.81 µM 1.10078913671422 0.155256656389254 no 578 0.135494220406966 752 2788239 SGTC_772 k072-0172 35.3 µM 1.10036295179152 0.155349857538051 no 579 0.135587006892273 643 5861980 SGTC_70 0141-0289 43.283 µM 1.0915577395531 0.157283704452488 no 580 0.137513769950244 904 352408 SGTC_2069 5228469 200 µM 1.09078163474675 0.157454912398708 no 581 0.137684489713241 671 2835210 SGTC_2611 pyromycin 23.93 µM 1.09038578096921 0.15754228449822 no 582 0.137771621342091 684 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_340 k038-0059 454 µM 1.09028584071095 0.157564348159632 no 583 0.137793625203724 720 23733424 SGTC_1649 st011737 51.3 µM 1.0901570439593 0.157592785420198 no 584 0.13782198594001 704 1761035 SGTC_1734 st037168 69.4 µM 1.08669387118226 0.158358689727295 no 585 0.138586061745582 704 708907 SGTC_1702 st027038 51 µM 1.08579319952584 0.158558278888355 no 586 0.13878524787947 731 5521182 SGTC_1729 st035615 45.989 µM 1.08319108685358 0.159135834377878 no 587 0.139361807569198 690 17385451 SGTC_1332 1480-0653 17.5 µM 1.08031378660003 0.15977607190852 no 588 0.140001236242595 713 5749438 SGTC_2318 6029776 164 µM 1.07703559131517 0.160507564800273 no 589 0.140732182786444 723 818325 SGTC_1034 k072-0165 12.7 µM 1.07677520696871 0.16056576032089 no 590 0.140790352081722 767 5835461 SGTC_268 camptothecin 39.6153 µM 1.07658308262814 0.160608708665654 no 591 0.14083328269837 815 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2442 5158906 48.48 µM 1.07333915013922 0.161335004814806 no 592 0.141559487766613 745 1893835 SGTC_2735 sertaconazole 140 nM 1.07210502409846 0.16161187953754 no 593 0.141836431256436 682 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_27 0485-0001 32.618 µM 1.07123581802941 0.16180707068476 no 594 0.142031705111148 660 2054479 SGTC_124 0136-0217 7.121 µM 1.07067183140788 0.161933803109287 no 595 0.142158506367733 854 3976905 SGTC_614 0462-0418 107 µM 1.07002750711806 0.162078667182517 no 596 0.142303463696833 671 5188303 SGTC_1301 naphtanilide LB 4.81 µM 1.06875531836173 0.162364942409707 no 597 0.14258996887386 797 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_598 3937-0236 20.2 µM 1.06857818575552 0.162404827893858 no 598 0.14262989120293 788 1379313 SGTC_2343 7990716 14.84 µM 1.06742109766243 0.162665529786659 no 599 0.142890862837296 751 6456862 SGTC_3301 9125354 19.7965 µM 1.06679128536228 0.162807546265112 no 600 0.143033047335277 662 41905162 SGTC_1426 4048-4480 71.7 µM 1.06595120512932 0.162997101562374 no 601 0.143222850024954 750 14224343 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.06014273516239 0.164311645473078 no 602 0.144539834205154 715 641818 YHR062C RPP1 SGTC_2056 5235370 200 µM 1.05947949976073 0.164462181647967 no 603 0.14469073032457 704 5511916 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.05782585366129 0.164837902960066 no 604 0.145067421851593 742 7104 SGTC_297 0986-0032 24 µM 1.05495394867295 0.165491742315605 no 605 0.145723193441743 716 2847425 SGTC_2200 6600604 21.907 µM 1.05353647768016 0.165815071851679 no 606 0.146047592546687 769 2904777 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.05007124233404 0.166607220937608 no 607 0.146842679648187 803 676296 Flavone; oxidizing agent. SGTC_2225 6654152 15.4 µM 1.04689951652611 0.167334411343517 no 608 0.14757296244398 678 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.0446988219635 0.167840170895609 no 609 0.148081094737659 767 16623 A steroid. SGTC_769 0302-0231 76 µM 1.04195253700994 0.168472695894206 no 610 0.148716842324951 841 571869 YER009W NTF2 SGTC_569 4130-2812 160 µM 1.04065338812582 0.16877244950377 no 611 0.149018221794619 642 743552 SGTC_704 1310-0270 142 µM 1.03928008439413 0.169089685302021 no 612 0.149337247176226 767 5718033 SGTC_2337 9009472 200 µM 1.03491674022354 0.170100165468074 no 613 0.150353898025055 790 5742383 SGTC_987 1497-1013 404 µM 1.03267445930623 0.170620943827859 no 614 0.150878134936681 745 1676435 SGTC_1037 k284-1091 78.7 µM 1.03152261104881 0.170888861439113 no 615 0.151147905245493 719 3334711 SGTC_74 000s-0487 160.283 µM 1.0290000755563 0.171476537858129 no 616 0.151739819679823 775 677548 SGTC_3213 9129884 49.47 µM 1.02816810395789 0.171670645620698 no 617 0.151935379664103 681 17190742 SGTC_2654 protoveratrine a 100 µM 1.02524881478901 0.172352856472125 no 618 0.152622900259514 765 5702278 A heart drug and vasodilator. SGTC_1819 st053448 58.6 µM 1.02442340274321 0.172546060831886 no 619 0.152817666418527 775 2857616 SGTC_2254 7938975 95.19 µM 1.02280322946195 0.172925696536861 no 620 0.153200445398882 848 2969277 SGTC_2818 7996756 12.99 µM 1.02145414304718 0.173242217499531 no 621 0.153519662314224 702 2241621 SGTC_835 0312-0010 67.2 µM 1.02117567109819 0.173307598145007 no 622 0.153585608347492 741 1626196 SGTC_755 1995-0008 37.3 µM 1.02049321108981 0.173467894977509 no 623 0.153747303682923 807 689533 SGTC_1143 3454-2408 5.08 µM 1.01989629262173 0.173608177074511 no 624 0.153888824006492 750 X1143 SGTC_3241 9133421 49.47 µM 1.0167783969595 0.174342088015183 no 625 0.154629430616689 782 17018221 SGTC_702 1488-0190 94 µM 1.01555186186104 0.174631337418074 no 626 0.154921419042479 785 949357 SGTC_958 1222-0007 33 µM 1.01305465178164 0.175221186705771 no 627 0.155517028598681 839 7312461 SGTC_2092 5303694 80.6725 µM 1.01009087931926 0.175922877181753 no 628 0.15622587577969 800 1963699 SGTC_690 glyoxal 20.3 µM 1.00905201049249 0.176169256068488 no 629 0.156474845665868 776 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_891 0929-0073 133 µM 1.00870857177919 0.176250754255147 no 630 0.156557209828545 800 5603632 SGTC_2035 5154463 94.595 µM 1.00839407698581 0.176325404958923 no 631 0.156632657634149 798 2769623 SGTC_3051 9093778 49.47 µM 1.00758050582174 0.176518612755118 no 632 0.156827945690213 738 17217378 SGTC_2385 9074692 200 µM 1.00403363998146 0.177362490003821 no 633 0.157681199599633 793 17046906 SGTC_2051 5263410 176 µM 1.00165124096077 0.177930742668043 no 634 0.158256031837965 822 227584 SGTC_1693 xanthone 101.9 µM 1.00080582678989 0.178132667569193 no 635 0.158460346001932 828 7020 An insecticide. SGTC_1437 4092-1038 11.6 µM 0.999087400133593 0.178543554173719 no 636 0.158876177143583 846 3977136 SGTC_459 nigericin 15.3 µM 0.996617986276456 0.179135050847587 no 637 0.159474986072446 839 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_160 3453-0671 289.699 µM 0.995917201530437 0.179303133532431 no 638 0.15964518836404 875 5322268 SGTC_3193 9111931 49.47 µM 0.994387572672404 0.179670358196213 no 639 0.160017107977319 807 17087244 SGTC_1608 st001473 40.5 µM 0.99409153134511 0.179741484671671 no 640 0.160089153947296 773 7292267 SGTC_2168 5727979 200 µM 0.990669813351215 0.180564865300881 no 641 0.160923417865753 731 695210 SGTC_1074 carmofur 3.8 µM 0.99033318871571 0.180645996143433 no 642 0.161005644833519 877 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_676 falcarinol 140 µM 0.98533840693111 0.181852487177283 no 643 0.162228936587571 857 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2742 clothiapine 36.27 µM 0.984153247623365 0.182139500909113 no 644 0.162520084600776 767 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2516 gossypol 71.55 µM 0.981939273686767 0.182676423961145 no 645 0.163064883005011 851 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_930 2810-3379 265 µM 0.981312488799901 0.182828608341482 no 646 0.163219332967957 890 1015764 SGTC_86 0417-1630 471.922 µM 0.981241940107057 0.182845742631293 no 647 0.163236723260158 922 3634867 SGTC_2495 cafestol 54.53 µM 0.981011588484762 0.182901695528986 no 648 0.163293513446606 761 16667697 An anti-infammatory. SGTC_2370 9071495 200 µM 0.979970260026781 0.183154769738782 no 649 0.163550399542296 770 21791103 SGTC_1872 amphotericin b 148 nM 0.978599123603995 0.183488330189521 no 650 0.163889046245475 867 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1364 1653-0028 37.6 µM 0.973632613643204 0.184699714762893 no 651 0.165119493464575 820 5718652 SGTC_353 1988-1175 58.3 µM 0.973285892960212 0.184784468891863 no 652 0.165205615862428 770 2788357 SGTC_2984 9022109 38.96 µM 0.973128136060864 0.184823039774201 no 653 0.165244810923924 812 6459207 SGTC_501 nsc-95397 161 µM 0.972695975205085 0.184928726870059 no 654 0.165352213095637 813 262093 SGTC_1749 st037932 54.2 µM 0.971653966722038 0.185183709651091 no 655 0.165611362498554 780 594497 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.971055029911726 0.185330370163729 no 656 0.165760437983172 808 5355888 SGTC_35 0133-0054 64.071 µM 0.968249493194728 0.186018316220365 no 657 0.16645989114729 782 99677 SGTC_45 0kpi-0036 14.9 µM 0.965525726990268 0.186687723830716 no 658 0.167140778213349 788 2795021 SGTC_906 1165-0455 526 µM 0.965445232548614 0.186707529243566 no 659 0.16716092749213 815 3252859 SGTC_77 0828-0286 12.516 µM 0.965359460171735 0.186728634707717 no 660 0.167182399661065 831 745345 SGTC_3077 9117319 49.47 µM 0.965214631738872 0.18676427507258 no 661 0.167218659898246 794 17154678 SGTC_1526 st051518 75 µM 0.964939901896217 0.186831894027412 no 662 0.167287457069292 759 673993 SGTC_1844 rapamycin 4 nM 0.960203604137226 0.188000014902362 no 663 0.168476376645185 909 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1324 1418-0026 34.4 µM 0.959940550828271 0.188065024057936 no 664 0.16854256794138 860 1372513 SGTC_2320 7373003 200 µM 0.959116304042866 0.188268812484394 no 665 0.168750078878012 826 5415828 SGTC_1430 4049-0248 69.1 µM 0.958519795928954 0.188416379290512 no 666 0.168900357084037 938 22774488 SGTC_1947 st076332 61.6 µM 0.957473795277 0.188675315713143 no 667 0.16916408337819 813 24208416 SGTC_531 3788-1495 174 µM 0.957149730776603 0.188755582045006 no 668 0.169245842806317 805 2896655 SGTC_1144 3486-0183 12.5 µM 0.954303132371588 0.189461549475588 no 669 0.169965111469261 878 6744069 SGTC_1754 st042065 16.137 µM 0.952836435964646 0.189825929310794 no 670 0.170336475055871 926 1126236 YIL048W NEO1 SGTC_1552 6-methylflavone 10.6 µM 0.95136745397321 0.19019130857249 no 671 0.17070893791232 826 689013 SGTC_3281 9140613 49.47 µM 0.950996480345954 0.190283648980387 no 672 0.17080308128612 775 16013766 SGTC_1762 st045503 25.4615 µM 0.949959074111779 0.190542019731607 no 673 0.171066524103155 867 4645554 SGTC_829 1635-0120 117 µM 0.949940335373345 0.190546688679353 no 674 0.171071285076831 894 285054 SGTC_2417 cerulenin 830 nM 0.947847889278832 0.191068484698648 no 675 0.171603448416233 841 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_293 4049-0273 38.5 µM 0.946930507071665 0.191297529538267 no 676 0.171837095667305 804 1380311 SGTC_979 1426-2828 121 µM 0.943814415362296 0.192076786905855 no 677 0.172632246415385 910 747872 SGTC_2990 9074105 71.4286 µM 0.943505915484835 0.192154040612032 no 678 0.172711095496408 839 6502001 SGTC_1406 3909-7906 11.9 µM 0.943424539417029 0.192174421755221 no 679 0.172731898125379 875 X1406 SGTC_122 0236-0016 402.397 µM 0.943061332653018 0.19226540527529 no 680 0.172824766217119 923 6808838 SGTC_211 3455-0679 143.504 µM 0.942890599869823 0.192308183045377 no 681 0.172868431759756 886 748649 SGTC_715 0868-0130 184 µM 0.942296859126422 0.192456992437382 no 682 0.173020337889239 859 2876258 SGTC_3268 9137683 49.47 µM 0.942267610349472 0.192464324884724 no 683 0.173027823265767 841 1953228 SGTC_2610 ononetin 44.17 µM 0.942199934727617 0.192481291306453 no 684 0.17304514367014 853 259632 SGTC_2759 disulfiram 3.38 µM 0.940964231606556 0.192791245447863 no 685 0.173361594687382 817 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2369 9071472 200 µM 0.940498191683226 0.192908222415202 no 686 0.173481038391164 883 17296037 SGTC_1178 0988-0033 191 µM 0.939678900579493 0.193113971212392 no 687 0.173691145550889 861 5392207 SGTC_1737 st035557 69.7 µM 0.937268774395575 0.193720003159443 no 688 0.174310160392834 734 5716916 SGTC_865 0488-0499 301 µM 0.936996475823942 0.193788546110658 no 689 0.174380185359282 930 9634651 SGTC_16 erodoxin 22.806 µM 0.935605741966116 0.194138851932416 no 690 0.174738108551202 926 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1215 3852-0577 11.2 µM 0.933907562638607 0.194567121514728 no 691 0.175175788715189 946 2884876 SGTC_1684 st024538 14.6195 µM 0.930067355726252 0.195537714173998 no 692 0.176168105704159 891 6732859 SGTC_1579 chlormadinone acetate 49.4 µM 0.927025290024303 0.196308663878808 no 693 0.176956701860701 912 45114258 A steroidal progestin. SGTC_3295 9122362 53.5725 µM 0.926385586174621 0.196471017992594 no 694 0.177122816029245 818 4730473 SGTC_1557 sumaresinolic acid 42.3 µM 0.92592534548113 0.196587875436037 no 695 0.177242389271731 821 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3212 9128307 49.47 µM 0.922926706648462 0.197350275472765 no 696 0.178022700940888 752 27243542 SGTC_1481 3346-2004 36 µM 0.918842576196892 0.19839153209378 no 697 0.179088959600842 917 2770522 SGTC_1356 1502-0781 85.8 µM 0.918259542212956 0.198540447621752 no 698 0.179241501440455 862 567702 SGTC_1892 st058411 7.36 µM 0.915686883944152 0.199198347468699 no 699 0.179915573133873 947 3934738 SGTC_1223 0764-0573 147 µM 0.915607258395736 0.199218730850478 no 700 0.17993646148599 921 1609797 SGTC_2289 7946404 165.07 µM 0.911844933015021 0.200183281717749 no 701 0.180925176543083 931 1246120 YPR165W RHO1 SGTC_2517 totarol 10 µM 0.911365684424043 0.20030634833524 no 702 0.181051364029395 831 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_130 0136-0219 337.655 µM 0.910141169162069 0.200620998946041 no 703 0.181374032662876 901 234244 SGTC_2512 diallyl trisulfide 49.23 µM 0.909870766381208 0.200690521441308 no 704 0.181445334255488 876 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_341 1486-1430 230 µM 0.909092947857215 0.200890584784892 no 705 0.18165053240095 874 2054753 YPL210C SRP72 SGTC_3247 9135149 49.47 µM 0.907240278716398 0.201367593076106 no 706 0.182139873994089 857 8934436 YOR116C RPO31 SGTC_2241 6772625 37.8075 µM 0.905092743473626 0.201921369522702 no 707 0.182708128063666 870 2285411 SGTC_1344 1488-0097 29.1 µM 0.904981789239998 0.201950005599961 no 708 0.182737517433732 886 747966 SGTC_3197 9113331 49.47 µM 0.901637011553822 0.202814396974467 no 709 0.183624861630862 899 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1346 1488-2224 62.4 µM 0.901295825137003 0.202902693890712 no 710 0.18371552646983 923 3722427 SGTC_2726 cimetidine 79.27 µM 0.900483733055619 0.203112950600476 no 711 0.183931439135221 908 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2356 9061756 188.97 µM 0.899327240741597 0.203412599522431 no 712 0.184239190853767 926 20104043 SGTC_894 0960-0238 55.9 µM 0.898324797612424 0.203672547327022 no 713 0.184506207975035 941 6741907 YDL195W SEC31 SGTC_2514 salinomycin 42.74 µM 0.898200786837401 0.203704718851846 no 714 0.184539256994641 988 23682228 A polyether potassium ionophore. SGTC_1410 3909-8106 77.9 µM 0.898165238748152 0.203713941482058 no 715 0.18454873128177 900 1039210 SGTC_1896 st058441 89 µM 0.897626258196471 0.203853805610254 no 716 0.184692417598135 832 688759 SGTC_1234 0326-0494 15.5 µM 0.897546649177532 0.203874468804916 no 717 0.184713646385083 916 1547813 SGTC_2915 7971052 15.16 µM 0.897331732895631 0.203930258378257 no 718 0.184770964199997 760 5741558 SGTC_1669 st015249 58.4 µM 0.895351827902465 0.204444644718984 no 719 0.185299521532155 1018 722793 SGTC_1443 4112-3303 14 µM 0.893748957244134 0.204861641321191 no 720 0.185728112369661 927 704433 SGTC_1096 rimcazole 32.2 µM 0.892248083638047 0.205252560899258 no 721 0.186129987287539 860 18528119 A dopamine reuptake inhibitor. SGTC_1316 1272-0050 65.9 µM 0.890859457537152 0.205614638739341 no 722 0.18650228636692 908 7340392 SGTC_2775 cyproheptadine 69.59 µM 0.890641183312969 0.205671587198213 no 723 0.186560848926718 966 2913 A selective serotonin reuptake inhibitor. SGTC_1166 k206-0078 225 µM 0.890546565711236 0.205696276148246 no 724 0.186586238187116 935 5404595 SGTC_347 4534-1311 26.2 µM 0.890502109138404 0.205707876987322 no 725 0.186598168202078 909 2862016 SGTC_2903 5923464 63.88 µM 0.884522839053106 0.207271689058437 no 726 0.188207019517813 926 2876576 SGTC_701 4424-0219 185 µM 0.884387733104729 0.207307105554878 no 727 0.188243471293156 989 2911779 SGTC_2951 9072950 58.06 µM 0.883247166558637 0.207606234760956 no 728 0.188551371338074 1028 16488155 SGTC_1943 st076331 65.2 µM 0.883139429923296 0.207634503347054 no 729 0.188580471273438 974 24208415 SGTC_100 0086-0128 49.5915 µM 0.875839189961296 0.209555277205943 no 730 0.190558730856701 979 93297 SGTC_1229 0139-0193 12.2 µM 0.874896354857425 0.20980410738992 no 731 0.190815151310188 994 3090752 SGTC_1381 2324-0066 62.1 µM 0.874765409476374 0.209838679830025 no 732 0.190850780927115 878 10885928 SGTC_1205 4161-2785 76 µM 0.872368778398927 0.210472034101536 no 733 0.191503613688783 830 3498106 SGTC_316 k060-0003 58.6 µM 0.87126346897901 0.210764510308986 no 734 0.191805156008614 923 6152314 SGTC_236 1509-0011 5.31 µM 0.869463084222091 0.211241420639059 no 735 0.192296945613313 1102 3107280 SGTC_2057 5236571 38.335 µM 0.868539321966165 0.211486364542208 no 736 0.192549577807324 964 54684039 YBR257W POP4 SGTC_565 1418-0001 44.5 µM 0.866209188252107 0.212104958894308 no 737 0.193187727762045 982 2862145 SGTC_194 1486-1323 56.904 µM 0.866095177222561 0.212135253199465 no 738 0.19321898487169 957 5178754 SGTC_2701 st077767 14.721 µM 0.865288993425024 0.212349539546051 no 739 0.193440095204378 978 5721188 SGTC_600 1495-0418 41.6 µM 0.862327895380683 0.213137694058599 no 740 0.194253553206528 925 5377768 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.862310507869338 0.213142327120231 no 741 0.194258335960253 982 6728940 SGTC_671 0560-0003 407 µM 0.861827689945451 0.21327100183851 no 742 0.194391172521807 922 3238678 SGTC_348 k064-0012 10.7 µM 0.85900034101418 0.214025420972552 no 743 0.195170163932288 894 5066323 SGTC_2505 galangin 7.89 µM 0.858717836115265 0.214100886777942 no 744 0.19524810382245 882 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1175 0741-0056 27.6 µM 0.857333787824714 0.21447083263435 no 745 0.195630220242354 1034 765927 SGTC_2249 haloperidol 116.36 µM 0.857089343535483 0.214536209379107 no 746 0.19569775504495 1043 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.856796898966753 0.214614439041364 no 747 0.195778569904134 1057 6708784 An antioxidant flavonoid SGTC_2420 aureobasidin a 50 nM 0.855475512409363 0.214968119940174 no 748 0.196143977609996 989 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3256 9138902 49.47 µM 0.855272660816657 0.215022444933098 no 749 0.196200109477171 1008 17228773 SGTC_1967 st070177 51.4 µM 0.8540767924241 0.215342868352341 no 750 0.196531220884029 954 5729214 SGTC_456 gingerol 170 µM 0.853037818137863 0.215621478024432 no 751 0.196819166221051 1031 442793 A herb. SGTC_3145 9085516 49.47 µM 0.851856396621868 0.215938539934561 no 752 0.197146900148522 929 25236195 SGTC_2734 clemastine 41.6 µM 0.85060467741301 0.216274762399578 no 753 0.19749449514113 885 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2824 7998404 51.95 µM 0.848872150536433 0.216740633608096 no 754 0.19797621849279 919 837851 SGTC_1731 st035964 63 µM 0.848618908133174 0.216808778299233 no 755 0.198046691102878 922 6739575 SGTC_1192 1488-0095 21.4 µM 0.846652788839082 0.217338260227172 no 756 0.198594340410819 930 915875 SGTC_1953 st076800 12.1 µM 0.844365347751906 0.217955213800376 no 757 0.19923263994018 921 297591 SGTC_1879 gemcitabine 100 µM 0.842164894345032 0.218549657442013 no 758 0.199847830509405 972 60750 A nucleoside analog which inhibits DNA replication. SGTC_733 4069-0007 56.1 µM 0.840709685715467 0.218943288461368 no 759 0.200255296569805 995 5717425 YNL287W SEC21 SGTC_1450 4112-4260 37.6 µM 0.840467369361804 0.219008874134828 no 760 0.20032319487329 1005 1633175 SGTC_2698 st077697 67.5 µM 0.839469303109505 0.219279131189739 no 761 0.200603004008512 927 3154499 SGTC_2629 bisabolol 100 µM 0.838336931838104 0.21958598742585 no 762 0.200920749720156 994 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1233 0325-0408 14.2 µM 0.838134475381909 0.219640876173915 no 763 0.200977591223477 983 12874 SGTC_1276 0871-0068 94.2 µM 0.837223427529886 0.219887971336953 no 764 0.201233495605356 969 3414906 SGTC_775 4577-0580 57.3 µM 0.836877710660765 0.219981778695794 no 765 0.201330655185265 1002 2006902 SGTC_2099 5377090 177.372 µM 0.836035218735629 0.220210477915233 no 766 0.201567545168362 951 2243829 SGTC_2826 7992541 19.48 µM 0.834533313622408 0.220618516588105 no 767 0.201990261436223 1034 2985066 SGTC_2286 7945697 125 µM 0.833614513426295 0.220868350283475 no 768 0.202249122243538 1001 1245733 SGTC_273 hydroxyurea 18.1 mM 0.831838014228375 0.221351862546842 no 769 0.202750191774201 1050 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1956 st077085 54 µM 0.83176814397343 0.221370891594774 no 770 0.20276991413991 1013 24208685 SGTC_523 1934-0222 13.7 µM 0.830011345953062 0.221849659978551 no 771 0.203266184404847 971 1361595 SGTC_2566 crystal violet carbinol 226 nM 0.829812113319204 0.221903992824973 no 772 0.203322510497381 888 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1003 4049-0218 100 µM 0.829260664916733 0.222054418255525 no 773 0.20347846189862 997 295161 SGTC_1886 st057356 49.9 µM 0.827865894793104 0.222435146733041 no 774 0.203873225765893 941 24207747 SGTC_2680 butyl paraben 22.24 µM 0.82668832700107 0.222756875441232 no 775 0.204206869625851 1014 7184 An antifungal and steroid mimetic. SGTC_3130 9127414 49.47 µM 0.826433325037806 0.222826580614893 no 776 0.20427916291538 1006 1494646 SGTC_885 0865-0106 16.8 µM 0.825634836055448 0.223044929160217 no 777 0.204505633819237 1031 2793380 SGTC_2429 5902844 64.44 µM 0.825339338561505 0.223125764470256 no 778 0.204589481963471 1035 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_185 k048-0037 25.491 µM 0.825192570519589 0.223165920045855 no 779 0.204631135359934 1044 6827589 SGTC_957 1187-1561 14.1 µM 0.824915797176528 0.223241656123229 no 780 0.204709698542757 1020 1538454 SGTC_1708 st033234 31.827 µM 0.8231118659888 0.223735640957125 no 781 0.205222190788976 1067 674664 SGTC_468 gf-109203x 121 µM 0.822946512569814 0.223780952070208 no 782 0.205269205382767 917 2396 A protein kinase C inhibitor. SGTC_2131 toluylene red 5.2905 µM 0.821292290828104 0.224234538633787 no 783 0.205739898913802 973 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_914 3820-6779 408 µM 0.820683551620975 0.2244015858486 no 784 0.205913271130185 1046 2893481 SGTC_1841 st054148 70 µM 0.818888049320124 0.224894709931945 no 785 0.206425144432774 935 675442 SGTC_1646 st011709 75.6 µM 0.817941348364578 0.225154962883523 no 786 0.206695339294099 984 5757843 SGTC_1958 st076513 41.9 µM 0.817872191470386 0.225173981153343 no 787 0.206715085344207 1025 732122 YGL099W LSG1 SGTC_264 promethazine 12.5 mM 0.817341014133142 0.225320086206664 no 788 0.206866787199813 1125 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1745 st081495 74 µM 0.816744701541526 0.225484171233885 no 789 0.207037169878486 1029 13842402 YBL026W LSM2 SGTC_1809 st050081 57.6 µM 0.816496432118648 0.225552506507008 no 790 0.20710813165903 1017 5036894 SGTC_231 b-estradiol 524 µM 0.816424281203836 0.225572367986778 no 791 0.207128756942459 955 450 A steroid. SGTC_277 nystatin 15.5 µM 0.816058684151642 0.225673023620596 no 792 0.207233286320611 1063 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3158 9100007 49.47 µM 0.815748304973537 0.225758496692748 no 793 0.207322052606496 1015 19297233 SGTC_1308 1187-1617 41.4 µM 0.815039448108185 0.22595377229808 no 794 0.207524865023271 1041 2882570 SGTC_3236 9132701 49.47 µM 0.813624066474984 0.226343966628467 no 795 0.207930173242324 994 24282524 SGTC_3097 9117246 49.47 µM 0.813193533123003 0.226462732095977 no 796 0.208053553278861 1075 16423892 SGTC_141 0443-0274 32.331 µM 0.812875014058601 0.226550620324643 no 797 0.208144860641846 1170 1627241 SGTC_841 0251-0215 91.2 µM 0.811935597602771 0.2268099434461 no 798 0.208414293481193 1063 3888614 SGTC_449 xestospongin c 11.1929 µM 0.811504371956576 0.226929038061826 no 799 0.208538041611347 1020 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2044 5102272 200 µM 0.810959362016871 0.227079607729672 no 800 0.208694504198871 964 592666 SGTC_2571 chrysanthemic acid 100 µM 0.809682753927232 0.227432516103365 no 801 0.209061266238599 962 2743 An insecticide. SGTC_2095 5432005 200 µM 0.809248014394226 0.227552766945512 no 802 0.209186250952003 981 783734 SGTC_3322 9139058 2.11 µM 0.809204392245263 0.227564834997482 no 803 0.209198794456577 1014 4908926 YPR165W RHO1 SGTC_1581 himbacine 57.9 µM 0.809126162865542 0.227586478030169 no 804 0.209221290344202 1004 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2764 methyldopa 94.69 µM 0.808682670189236 0.227709197146376 no 805 0.209348849417162 1019 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1130 3454-2858 15.9 µM 0.807286407454501 0.228095800957645 no 806 0.209750746644328 952 715628 YIL048W NEO1 SGTC_2313 7726885 200 µM 0.80591219363067 0.228476659910638 no 807 0.210146739949738 991 726423 SGTC_3140 9094243 49.47 µM 0.805367968681574 0.228627588813706 no 808 0.210303685065489 1114 19291112 SGTC_2145 5634607 200 µM 0.804653929167333 0.228825696974712 no 809 0.210509706136137 983 308662 SGTC_2822 7994718 71.43 µM 0.802222605138686 0.229500982801925 no 810 0.21121210126733 951 1018011 SGTC_2557 derrustone 83.84 µM 0.801739770659631 0.229635219991599 no 811 0.211351752546463 1074 629853 An antioxidant. SGTC_1887 st057648 70.8 µM 0.801457503220194 0.229713716088057 no 812 0.211433418424616 1037 688672 SGTC_923 1900-2434 73.3 µM 0.801384517968561 0.229734015090571 no 813 0.211454537592041 1001 5910570 SGTC_2106 5357045 167.29 µM 0.799962839024453 0.230129619448079 no 814 0.211866163964123 1031 668842 SGTC_1937 st074714 47.2 µM 0.799864254330173 0.230157066301503 no 815 0.211894725092471 1063 17250970 SGTC_571 k831-0106 44.2 µM 0.799220993929029 0.230336200653985 no 816 0.212081140373262 999 4783639 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.798745719578307 0.230468604525474 no 817 0.212218935291346 1106 66535 A nucleotide analog. SGTC_655 k060-0012 42 µM 0.796891310715329 0.230985619951056 no 818 0.212757078910784 1021 5994525 SGTC_2188 6126565 140.678 µM 0.796629364069423 0.2310587037095 no 819 0.212833159167275 1000 874518 SGTC_1115 galangin 695.678 nM 0.796119967666346 0.231200863504418 no 820 0.212981154636514 1121 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2570 licareol 100 µM 0.794821385076908 0.231563486098416 no 821 0.21335870473659 972 443158 SGTC_3011 9081274 71.4286 µM 0.79411901828348 0.231759750490822 no 822 0.213563073448521 1053 6625322 SGTC_2470 5664817 21.68 µM 0.79406563554095 0.231774671174228 no 823 0.213578610967449 1058 2859561 SGTC_1735 st034310 56.75 µM 0.792934828385937 0.232090861863042 no 824 0.213907897104806 1009 871153 SGTC_1651 st011928 86.1 µM 0.792619124066923 0.232179180396477 no 825 0.213999881585477 1030 720198 SGTC_2884 9058502 51.95 µM 0.791717141841816 0.232431613667654 no 826 0.214262812441436 1055 6471554 SGTC_2756 carbadox 75.1 µM 0.79107083708618 0.232612585592671 no 827 0.214451327970821 1008 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2541 muurolladie-3-one 83.07 µM 0.790810545433953 0.232685492030939 no 828 0.214527277620679 1001 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1562 morin hydrate 59.1 µM 0.78810536656758 0.23344395104949 no 829 0.21531753819597 1031 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2018 5133068 143 µM 0.787012658442621 0.233750705291275 no 830 0.21563722803126 1008 785362 SGTC_522 1273-0010 11.6 µM 0.78578979784817 0.234094261799619 no 831 0.215995322252591 1063 5705015 SGTC_3175 9106517 49.47 µM 0.785596730710732 0.234148528585207 no 832 0.216051890198847 1029 41468073 SGTC_3353 9151644 39.2805 µM 0.785019206574052 0.234310899073155 no 833 0.216221153821229 1032 4909158 SGTC_1759 st043059 70 µM 0.78459471687583 0.23443028376711 no 834 0.216345614298984 1080 669426 SGTC_1670 st016595 4.04 µM 0.783722484249495 0.234675698557117 no 835 0.21660148321354 1105 597879 SGTC_551 k048-0028 34.9 µM 0.782928268625195 0.234899285693227 no 836 0.216834618083111 1087 6836383 SGTC_1433 4060-0023 7.6 µM 0.782858244890995 0.23491900438123 no 837 0.216855179879002 1058 3840627 SGTC_860 0443-0016 25.1 µM 0.781987676893332 0.235164232749179 no 838 0.217110907904461 1117 5337942 SGTC_2766 oltipraz 83.91 µM 0.780906068433832 0.235469105470003 no 839 0.217428871331534 1028 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_431 k089-0097 107 µM 0.780874797339392 0.235477923088845 no 840 0.217438068178491 1063 5499420 SGTC_1105 epirubicin 18.1 µM 0.780546930281042 0.235570383868223 no 841 0.217534507590364 1055 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_741 4582-0002 126 µM 0.780422377293888 0.235605513921347 no 842 0.217571150301983 1041 2912688 SGTC_1939 st074455 53.6 µM 0.778315682028064 0.236200142953956 no 843 0.218191466364209 1063 1644229 SGTC_1782 st039423 80.636 µM 0.775674043022459 0.236946930076481 no 844 0.218970734882283 1007 2068169 SGTC_2269 7935389 174.42 µM 0.773405909624807 0.237589161958126 no 845 0.21964109682129 1016 97605 SGTC_3082 9117008 49.47 µM 0.772675848394552 0.237796085025559 no 846 0.219857121739958 1057 41448529 SGTC_3319 9138450 16.7555 µM 0.769310627865758 0.238751174509053 no 847 0.220854464761786 1043 2029690 SGTC_1991 st073000 8.92 µM 0.769212644323927 0.238779014807014 no 848 0.220883542685712 1096 4301969 YIL048W NEO1 SGTC_2005 4024620 188 µM 0.768877106257748 0.238874365492195 no 849 0.220983134688273 1081 236743 SGTC_2279 7948423 32.93 µM 0.768874330748506 0.238875154302375 no 850 0.220983958602187 1067 1247112 SGTC_380 3970-0968 6 µM 0.764822573930711 0.240028196535679 no 851 0.222188601870018 1052 2891601 SGTC_1583 clindamycin 39.6 µM 0.764749345172355 0.240049063735721 no 852 0.222210408213268 1008 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1591 genipin 88.4 µM 0.764365169162074 0.240158554384323 no 853 0.222324829641621 1036 442424 A DNA cross-linking agent. SGTC_3259 9138485 49.47 µM 0.761898003219956 0.240862348072425 no 854 0.223060440924511 1206 17646153 SGTC_2867 9039098 71.43 µM 0.761756077718895 0.240902868414033 no 855 0.223102799611602 1092 6463460 SGTC_1132 3456-3614 2.5 µM 0.759996876833716 0.241405435548953 no 856 0.223628225866928 1168 3125502 SGTC_724 3910-0327 137 µM 0.75605951378081 0.242532319315737 no 857 0.224806757214868 1124 2885483 SGTC_424 splitomicin 100 mM 0.754373487467371 0.24301573428931 no 858 0.22531249341006 1031 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2859 9028643 45.46 µM 0.753748852204607 0.243194961007591 no 859 0.225500020860242 1080 17151580 SGTC_1856 st057054 55.7 µM 0.751126161330498 0.243948269537919 no 860 0.226288366294811 1134 1266018 SGTC_1506 4226-2149 212 µM 0.74949709367798 0.244416815408579 no 861 0.22677882485329 1141 991114 SGTC_1137 ixabepilone 100 µM 0.748677797601175 0.244652641180137 no 862 0.227025714381552 1105 154225 A novel microtubule stabilizer. SGTC_2816 7982706 58.44 µM 0.748631773530506 0.24466589235943 no 863 0.227039587929584 1091 2981853 SGTC_198 3454-2873 16.191 µM 0.747969191590724 0.244856704752856 no 864 0.22723937035182 1125 710957 SGTC_687 k029-0044 34.9 µM 0.747888756802628 0.244879874061856 no 865 0.227263629877743 1143 5829338 SGTC_1912 st060209 90.8 µM 0.747627658164065 0.244955091876822 no 866 0.22734238856284 1089 688787 SGTC_1314 1222-0010 41.1 µM 0.746705434032694 0.245220867507754 no 867 0.227620694447671 1105 3526027 SGTC_688 0527-0193 473 µM 0.742811033863308 0.24634490182857 no 868 0.228798047142515 1085 4007154 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.740984149661405 0.246873142505098 no 869 0.229351525449399 1063 15053 SGTC_1833 st055984 71 µM 0.739149002826093 0.247404382097041 no 870 0.229908261867695 1120 676288 SGTC_1277 0873-0036 22 µM 0.736971160487325 0.248035617334345 no 871 0.230569943781387 1169 5965735 SGTC_2913 7966556 36.57 µM 0.736401070414578 0.248200996498142 no 872 0.230743326711105 1077 2976516 SGTC_2152 5568786 200 µM 0.736084514001512 0.248292852696703 no 873 0.2308396332489 1122 5399883 SGTC_833 3852-0053 558 µM 0.735730005800221 0.248395742998666 no 874 0.230947512569156 1168 3123681 SGTC_2969 9091408 28.7 µM 0.73461072621529 0.248720744977761 no 875 0.231288301815012 1061 4286311 SGTC_546 peri-Naphthalide 147 µM 0.733385600968084 0.249076740470823 no 876 0.231661639430734 1097 223824 A penicillin ester. SGTC_1046 2001-0062 216 µM 0.732547111789383 0.249320543857825 no 877 0.231917349251538 1071 739778 SGTC_2177 5811945 192 µM 0.731992161258646 0.24948197384695 no 878 0.23208667612791 1154 5343475 SGTC_977 1348-1378 135 µM 0.729575512199906 0.250185601851616 no 879 0.232824847506913 1174 X977 SGTC_3174 9107204 49.47 µM 0.728549898874668 0.250484535732284 no 880 0.233138517454472 1150 3938802 SGTC_450 aminopyrene 156 nM 0.727941000653872 0.250662099827429 no 881 0.233324851660987 1125 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2240 6690706 185.951 µM 0.726998476451439 0.250937085809147 no 882 0.233613444529983 1067 805876 SGTC_1900 st060200 72.8 µM 0.725889634253396 0.251260800156932 no 883 0.233953215796247 1170 688945 SGTC_745 0469-0705 296 µM 0.722027855625007 0.252389925588568 no 884 0.235138675815081 1238 3486736 SGTC_2192 5915882 198.485 µM 0.721600258970921 0.252515112614313 no 885 0.235270139946658 1114 2876149 SGTC_1469 k284-2957 126 µM 0.720970827012163 0.252699450261208 no 886 0.235463731936945 1188 23884841 SGTC_1982 st072467 71.9 µM 0.719928861917303 0.253004759493914 no 887 0.235784398288519 1125 3163533 SGTC_245 methotrexate 289.6 µM 0.718545485120689 0.253410406471019 no 888 0.236210506408024 1145 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1781 st038725 66.3 µM 0.718156582471369 0.253524505749374 no 889 0.236330372643102 1179 4270275 YIL048W NEO1 SGTC_332 4112-0506 40.9 µM 0.716291507632724 0.254072070776365 no 890 0.236905684751211 1159 2790355 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.715834492651077 0.254206339815076 no 891 0.237046775674055 1183 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_218 alverine citrate 93.75 µM 0.714029640967804 0.25473696089934 no 892 0.23760442547463 1138 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2924 9010168 62.78 µM 0.713787630242635 0.254808155409123 no 893 0.237679254865933 1190 2993929 SGTC_1459 k035-0031 35.7 µM 0.713758464648512 0.25481673602208 no 894 0.237688273701365 1077 3877128 YMR208W ERG12 SGTC_683 panaxydol 45 µM 0.7125531840905 0.25517146573516 no 895 0.238061145057033 1159 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_900 1112-0045 141 µM 0.712158077252273 0.255287806983042 no 896 0.238183446934778 1081 56211 YIL048W NEO1 SGTC_1713 st033146 12.748 µM 0.71075288197844 0.25570179855654 no 897 0.238618691692147 1168 674619 SGTC_2534 helenine 20.12 µM 0.709859890229473 0.255965069353193 no 898 0.238895512726058 1177 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_653 0203-0016 55.2 µM 0.709170417113016 0.256168435731791 no 899 0.239109364533569 1187 295302 SGTC_90 0870-0863 4.608 µM 0.708895669503951 0.256249498512976 no 900 0.239194611320714 1181 1738164 SGTC_2312 7706453 155.7 µM 0.705194488127625 0.257342813961723 no 901 0.240344605486581 1191 976098 SGTC_1396 3511-0007 98.6 µM 0.704581862503471 0.257524014885736 no 902 0.240535244529253 1134 X1396 SGTC_1891 st059073 26.2 µM 0.704229840956477 0.257628164939236 no 903 0.240644825096099 1229 688754 SGTC_1140 3229-1848 2.98 µM 0.704023606211722 0.257689192271256 no 904 0.240709036402164 1187 2849525 SGTC_2482 5981709 142.65 µM 0.702573808228137 0.258118416598502 no 905 0.24116069491458 1158 877755 SGTC_2379 9035213 200 µM 0.696886118559674 0.259805875684007 no 906 0.242937032840437 1207 646551 SGTC_2122 5258151 111.688 µM 0.696444394357705 0.259937166960425 no 907 0.243075284539859 1191 2173356 SGTC_2529 gangaleoidin 93.61 µM 0.69440402808093 0.260544057697682 no 908 0.243714434162757 1231 4565183 SGTC_1468 k284-1086 134 µM 0.694144658545108 0.260621257335112 no 909 0.243795747240178 1205 15996457 SGTC_1188 1403-0014 4.57 µM 0.693959283675445 0.260676440160629 no 910 0.243853871753685 1230 9614867 SGTC_828 2074-0507 139 µM 0.692883071162086 0.260996928377465 no 911 0.244191467175426 1230 X828 SGTC_1478 0453-0656 35.7 µM 0.691643701750188 0.261366254361558 no 912 0.244580555014614 1227 5258496 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.690312011965399 0.261763390311233 no 913 0.244998997796432 1237 279621 SGTC_721 1187-1332 279 µM 0.690170325398999 0.261805662230956 no 914 0.245043541124058 1138 25730 SGTC_973 1325-0077 65.9 µM 0.688818895208957 0.262209034786602 no 915 0.24546862169462 1239 2835149 SGTC_803 4488-1585 147 µM 0.688252512897221 0.262378182240502 no 916 0.245646890056244 1180 747204 SGTC_405 ebelactone b 50 µM 0.685374300938779 0.26323860951056 no 917 0.24655387830063 1204 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2853 9015042 58.44 µM 0.684869195103808 0.263389756927496 no 918 0.246713233160402 1159 6457456 SGTC_3291 9121177 71.43 µM 0.68478209397834 0.263415825468499 no 919 0.246740718099631 1156 17015612 SGTC_747 3448-8087 38.7 µM 0.683823739529909 0.263702738815935 no 920 0.247043237044438 1227 5168703 SGTC_2780 5215298 71.43 µM 0.682334177811054 0.264149001856985 no 921 0.247513833146263 1221 2834131 SGTC_921 1561-0023 372 µM 0.682284972085428 0.264163750134758 no 922 0.247529386842025 1223 24050882 SGTC_2834 9001755 58.44 µM 0.682072510961719 0.264227435255849 no 923 0.247596550787137 1146 2989575 SGTC_964 1287-0107 19.4 µM 0.681233019526053 0.264479148877028 no 924 0.247862028921183 1219 51516812 YPR165W RHO1 SGTC_2153 5569715 200 µM 0.679868600052972 0.264888517413649 no 925 0.248293832603343 1228 2054701 SGTC_3127 9126946 49.47 µM 0.679752020605901 0.264923509823781 no 926 0.248330745589856 1160 27243249 SGTC_3347 9188721 44.724 µM 0.679305770945392 0.265057477532045 no 927 0.248472070317382 1217 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1326 1431-2094 10.8 µM 0.677766445455936 0.265519859278708 no 928 0.248959894663246 1202 616278 SGTC_2221 6807166 181.081 µM 0.675410944453937 0.266228194648559 no 929 0.249707357011597 1183 674925 SGTC_685 1278-0033 54.9 µM 0.675261689894806 0.266273109994529 no 930 0.249754759522238 1274 3590572 SGTC_2895 9054447 58.44 µM 0.674490759476595 0.26650516802269 no 931 0.249999679274407 1257 2697450 SGTC_663 1486-0733 13.9 µM 0.674056402228041 0.266635959083157 no 932 0.250137727954939 1232 722445 YPR165W RHO1 SGTC_4 0960-0234 25.671 µM 0.673102201148321 0.266923396321118 no 933 0.250441136834359 1228 6821112 SGTC_788 1182-0090 188 µM 0.672815864257878 0.267009681079282 no 934 0.250532221875784 1304 5715185 SGTC_3351 9150312 21.596 µM 0.67270511404116 0.267043058326761 no 935 0.250567456720314 1212 4904905 SGTC_607 4491-0986 66.8 µM 0.671205395056792 0.267495242126848 no 936 0.251044846119868 1255 698981 YDR232W HEM1 SGTC_2519 cryptotanshinone 88.04 µM 0.670664423789206 0.267658446352161 no 937 0.251217165704225 1219 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3027 9089541 49.47 µM 0.668964820602721 0.268171521565969 no 938 0.25175895960349 1229 9943819 SGTC_2248 tofa 1.1 µM 0.667507691898677 0.268611792436155 no 939 0.252223949049235 1203 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_917 harmaline 728.087 nM 0.667087476057584 0.26873882793907 no 940 0.252358129684502 1229 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.664558301634706 0.269504059900051 no 941 0.253166523610724 1211 17037758 SGTC_1460 k062-0059 9.15 µM 0.6637660183712 0.269743999107523 no 942 0.253420039055826 1213 1373085 SGTC_2587 piperic acid 92.2 µM 0.662133126488176 0.270238849845113 no 943 0.253942953686113 1210 5370536 SGTC_1079 idarubicin 2.36 µM 0.662088616644011 0.270252344984025 no 944 0.253957215369328 1224 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2430 5571206 200 µM 0.661035266866056 0.270571813135497 no 945 0.254294848525457 1286 1731771 SGTC_1084 voriconazole 435 nM 0.660990597530625 0.270585364969016 no 946 0.254309171712225 1256 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2423 st077119 87.2 µM 0.657910552386007 0.271520609415434 no 947 0.255297804776839 1219 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_50 0929-0078 56.389 µM 0.657656293898857 0.271597885954356 no 948 0.255379506358813 1182 1377751 SGTC_3304 9125678 46.087 µM 0.654079918274882 0.272686009381029 no 949 0.256530159314587 1251 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2821 7996764 71.43 µM 0.653977669086056 0.272717150796619 no 950 0.256563096342609 1322 2987135 SGTC_14 0354-0009 295 µM 0.653603281073231 0.272831190942297 no 951 0.256683714906014 1290 1713507 SGTC_2985 9022375 71.43 µM 0.653468061294769 0.272872385262882 no 952 0.256727286632849 1299 4939335 SGTC_2038 4100038 30.985 µM 0.652708541508368 0.273103828114592 no 953 0.256972097431517 1257 3596803 SGTC_1785 bathophenanthroline 24 µM 0.652303300228009 0.27322735408491 no 954 0.257102765740288 1239 72812 An iron chelator. SGTC_49 0717-0965 32.132 µM 0.651680023573001 0.273417395780566 no 955 0.25730380603982 1339 5889349 YGL099W LSG1 SGTC_1963 st076565 50.3 µM 0.651026650032285 0.273616684478121 no 956 0.257514641891259 1277 4914280 SGTC_10 0279-0212 42.575 µM 0.649875406711583 0.273968005702896 no 957 0.257886352623602 1281 39851 YBR002C RER2 SGTC_509 pifithrin 175 µM 0.649416313975583 0.27410816771502 no 958 0.258034661013098 1316 4817 A p53 inhibitor. SGTC_2889 9059656 51.95 µM 0.648468677853217 0.274397595073251 no 959 0.258340931561073 1324 3949838 SGTC_97 0535-0701 19.132 µM 0.647129468224156 0.274806873994938 no 960 0.258774077405211 1228 2832013 YGL099W LSG1 SGTC_2167 5876490 200 µM 0.644013677391889 0.275760260944209 no 961 0.259783282414926 1355 686534 SGTC_934 2950-0684 338 µM 0.643779622050144 0.275831944083602 no 962 0.259859174895421 1283 1121253 SGTC_2007 4011539 71.82 µM 0.642518803431501 0.276218247095451 no 963 0.260268192197841 1307 45595301 SGTC_2846 9008642 19.48 µM 0.641148037554744 0.276638537932981 no 964 0.260713253151666 1278 2992898 SGTC_1496 4469-0713 57.4 µM 0.640443445291277 0.276854695014124 no 965 0.260942172820136 1263 746691 SGTC_1916 st067606 49.2 µM 0.640422272379683 0.276861191788018 no 966 0.260949053427674 1310 19590279 SGTC_535 2293-4129 48.2 µM 0.639517110901187 0.277139004661492 no 967 0.261243292968582 1296 396118 YIL048W NEO1 SGTC_1662 st014054 52 µM 0.638356439646158 0.277495438269793 no 968 0.261620839988515 1276 2838777 SGTC_1767 st044992 70.3 µM 0.637657206567614 0.27771027569764 no 969 0.261848423950483 1237 9600693 SGTC_3083 9117465 49.47 µM 0.637654862893462 0.277710995921612 no 970 0.261849186932136 1261 16420915 SGTC_3204 9114183 49.47 µM 0.637549940037061 0.277743240227712 no 971 0.261883345670481 1303 17027248 SGTC_2216 7189485 200 µM 0.634909201578039 0.278555378742828 no 972 0.262743817722897 1300 731273 SGTC_471 1-acyl-paf 4 µM 0.634765101527206 0.278599728849182 no 973 0.262790813616021 1230 16759367 SGTC_2860 9025725 38.96 µM 0.633561901535124 0.278970175505495 no 974 0.263183385515571 1247 40546248 SGTC_823 0417-1665 178 µM 0.632075165787976 0.279428249120984 no 975 0.263668880999243 1313 3429856 SGTC_1921 5740136 50 µM 0.628172347523902 0.28063246991011 no 976 0.264945521519059 1326 1774243 SGTC_2123 5259487 200 µM 0.628149445079012 0.280639543899608 no 977 0.264953022337047 1276 2173474 SGTC_963 1269-2853 151 µM 0.626470576107717 0.28115833913103 no 978 0.265503165249434 1274 3668223 SGTC_593 1203-0218 61.7 µM 0.62646221111777 0.281160925195345 no 979 0.265505907795001 1336 3666956 SGTC_947 3447-0010 211 µM 0.624442718872131 0.281785593838758 no 980 0.26616843880586 1309 748350 SGTC_2601 securinine 100 µM 0.623637115376523 0.282034969341415 no 981 0.266432964984835 1271 442872 A GABA receptor antagonist. SGTC_1678 st019265 80.2 µM 0.62247794656938 0.282393977775526 no 982 0.266813820306857 1343 5367020 SGTC_2115 tiliquinol 12.7705 µM 0.622192259883932 0.282482492108659 no 983 0.266907727471046 1314 71208 A bioactive hydroxyquinoline. SGTC_2811 7967822 32.47 µM 0.620188977592485 0.283103543739759 no 984 0.267566688721178 1348 2232244 SGTC_2067 5224629 34.075 µM 0.620087986646229 0.283134869994025 no 985 0.267599930466318 1292 2835000 SGTC_119 0121-0043 24.815 µM 0.619208378884613 0.283407784723995 no 986 0.26788954637561 1350 1092378 SGTC_862 0452-0056 10.2 µM 0.619135268227101 0.283430474345925 no 987 0.267913625583931 1260 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_635 k038-0028 24.7 µM 0.618368526130922 0.283668482354898 no 988 0.268166219971564 1352 4035102 SGTC_244 nsc-207895 1.295 µM 0.617841888258138 0.283832013925175 no 989 0.268339784178549 1219 42640 SGTC_404 fumagillin 50 µM 0.617707064680158 0.283873886591771 no 990 0.268384227109183 1328 12015870 A methionine aminopeptidase binder. SGTC_2964 9083345 53.42 µM 0.616753054323329 0.284170261636031 no 991 0.268698810595358 1282 17741579 SGTC_3138 9097216 49.47 µM 0.61628909590274 0.284314449479409 no 992 0.268851867117757 1314 25237486 SGTC_2881 9058953 51.95 µM 0.6154135917719 0.284586631685473 no 993 0.269140808800547 1279 17122249 SGTC_599 1935-0052 86.5 µM 0.615209356805296 0.284650143424561 no 994 0.269208234651429 1297 9557311 SGTC_272 doxorubicin 8.13 µM 0.612016665224303 0.285643865765728 no 995 0.270263365783684 1315 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2830 7992007 71.43 µM 0.611107131657732 0.285927259070449 no 996 0.270564329396956 1314 1952075 SGTC_1291 0993-0025 5.79 µM 0.610802560323742 0.286022187550269 no 997 0.270665149107552 1364 4353356 SGTC_3074 9116018 49.47 µM 0.609480838597888 0.286434313849622 no 998 0.271102884883826 1374 17027303 SGTC_489 paxilline 115 µM 0.609084551068359 0.28655793522989 no 999 0.271234198541405 1282 105008 A toxic potassium channel blocker. SGTC_2943 9068529 45.32 µM 0.607215052532327 0.287141463934335 no 1000 0.271854102025838 1329 3270634 SGTC_3147 9097027 49.47 µM 0.606269840890464 0.287436707881056 no 1001 0.272167791043963 1401 25236841 SGTC_943 3253-1379 105 µM 0.605647992019486 0.28763102530936 no 1002 0.272374263174641 1369 668464 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.602160924613035 0.288721824508887 no 1003 0.273533511669398 1418 165506 SGTC_1874 staurosporine 7.6 µM 0.601147891455373 0.289039078970781 no 1004 0.273870743851915 1375 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1808 st050063 61.5 µM 0.600557126670688 0.289224166114559 no 1005 0.274067500471506 1365 4011993 SGTC_2717 st081029 62.2815 µM 0.600524037876923 0.289234534511177 no 1006 0.274078522894361 1305 5292846 SGTC_441 propafenone 146 µM 0.597658265838755 0.290133188312826 no 1007 0.275033988921951 1297 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_407 eburnamonine 100 µM 0.597432982894384 0.290203888368253 no 1008 0.275109169146244 1293 3195 SGTC_373 0844-0104 25.9 µM 0.597313118699717 0.290241508376633 no 1009 0.275149173711392 1346 5375804 SGTC_1527 coumarin 137 µM 0.597297095492441 0.29024653751767 no 1010 0.275154521659186 1385 323 A hepatotoxic, DNA x-linker. SGTC_3263 9137018 49.47 µM 0.591817622441574 0.29196874691666 no 1011 0.276986360638845 1281 43844957 SGTC_3101 9120531 49.47 µM 0.591528624264259 0.292059711574315 no 1012 0.277083140923567 1399 24824904 SGTC_2388 9080168 200 µM 0.590238977905202 0.292465799537358 no 1013 0.277515221853283 1300 15943073 SGTC_1815 st051655 58.2 µM 0.590097061369397 0.292510502694618 no 1014 0.27756278943293 1330 5984156 SGTC_2862 9027634 71.43 µM 0.587988069244395 0.293175200950552 no 1015 0.278270150487108 1308 5012562 SGTC_2961 9083290 32.55 µM 0.587523264043425 0.293321789327123 no 1016 0.278426165383789 1384 17741490 SGTC_1209 2323-2347 50.3 µM 0.587405936624956 0.29335879694039 no 1017 0.278465553833271 1346 5412760 SGTC_2658 polymyxin b sulfate 77.05 µM 0.58734904246544 0.293376743371573 no 1018 0.278484654972911 1338 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_903 1134-0042 114 µM 0.585826172627947 0.293857299330983 no 1019 0.278996166835783 1339 701009 SGTC_1408 3909-7976 48.8 µM 0.585513293893144 0.293956076241393 no 1020 0.279101315230204 1379 24152374 SGTC_2888 9058547 12.99 µM 0.583844625340355 0.294483139841377 no 1021 0.279662425789314 1295 16476514 SGTC_457 grayanotoxin iii 135 µM 0.58343977740709 0.294611080330591 no 1022 0.279798643425924 1325 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2346 9031566 143.75 µM 0.583430027991541 0.294614161667793 no 1023 0.279801924171359 1385 4771086 SGTC_922 1866-0035 480 µM 0.583029705972963 0.294740697691648 no 1024 0.279936651398297 1413 3156169 SGTC_1153 4055-0057 267 µM 0.582323690799496 0.29496391996906 no 1025 0.280174335411303 1332 882706 SGTC_2465 5809242 33.21 µM 0.580950970027871 0.295398158744958 no 1026 0.280636749338774 1378 2731748 SGTC_1286 0929-0070 131 µM 0.578763305035679 0.296090799531162 no 1027 0.281374447116057 1434 1420408 SGTC_5 0352-0601 109.883 µM 0.577089906593827 0.296621119968506 no 1028 0.28193936119164 1309 762456 SGTC_1199 1638-0010 4.46 µM 0.57680867604427 0.296710288055479 no 1029 0.282034353983752 1350 3111136 SGTC_3205 9113483 49.47 µM 0.576296287910811 0.29687277943861 no 1030 0.282207465759468 1432 17018033 SGTC_1757 st041620 31.8375 µM 0.575527711231384 0.297116591086638 no 1031 0.282467227407123 1346 5289815 SGTC_2361 9034121 116 µM 0.570456129949416 0.29872771305254 no 1032 0.284184184402677 1383 6496917 SGTC_432 NS 1619 61.3 µM 0.57028285521261 0.298782828452255 no 1033 0.284242933700193 1384 4552 A K+/calcium channel activator. SGTC_806 3966-4455 5.86 µM 0.569244731100515 0.299113132740434 no 1034 0.284595034209112 1316 714982 SGTC_3305 9127027 53.8275 µM 0.56917560602456 0.299135132439629 no 1035 0.284618486751755 1368 41905295 SGTC_2355 9061122 103.12 µM 0.567033615390573 0.299817204563381 no 1036 0.285345671661457 1403 5302957 SGTC_2671 danthron 100 µM 0.565893073157212 0.300180673444477 no 1037 0.285733235330068 1362 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3080 9117754 49.47 µM 0.565300080869827 0.30036972737548 no 1038 0.285934836856081 1508 9550191 SGTC_999 SEC7.066 22.7 µM 0.564426221351303 0.300648423577941 no 1039 0.286232048914125 1443 740511 YDR170C SEC7 SGTC_1394 3474-0001 65.7 µM 0.562370596466116 0.301304474825523 no 1040 0.286931774070453 1354 5017666 YIL048W NEO1 SGTC_597 k018-0003 82.8 µM 0.561619453827669 0.301544362189607 no 1041 0.287187661549184 1497 6786234 SGTC_1089 terbinafine 2.25 µM 0.561122258841484 0.30170319524968 no 1042 0.287357097522355 1427 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_136 0097-0015 404.482 µM 0.560654957090403 0.301852512952092 no 1043 0.287516389466009 1394 4861337 SGTC_176 1486-1328 72.834 µM 0.558764629646688 0.302456871000614 no 1044 0.28816118236722 1377 22310231 SGTC_2456 5770359 74.46 µM 0.558761151934493 0.302457983362528 no 1045 0.288162369247374 1458 3118787 SGTC_3318 9139014 38.6185 µM 0.557617463917249 0.302823896572763 no 1046 0.288552814280871 1402 16643984 SGTC_857 0438-0306 1.35 µM 0.55739623406671 0.302894700047395 no 1047 0.288628368968295 1419 4686136 SGTC_1615 st002656 86.5 µM 0.556835256089167 0.303074271372953 no 1048 0.288819996611375 1385 1584458 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.55635646776246 0.303227571117063 no 1049 0.288983595981902 1372 4620898 SGTC_2930 9013230 14.89 µM 0.555504367131912 0.303500484723113 no 1050 0.289274861930407 1452 2995857 SGTC_415 dibenzyl ketone 100 µM 0.555285161785302 0.303570710273939 no 1051 0.289349813243161 1495 7593 SGTC_53 0973-0023 39.979 µM 0.552270101634397 0.30453736292886 no 1052 0.29038165585964 1404 674768 SGTC_1560 lithocholic acid 53.1 µM 0.551027910539077 0.304936017382148 no 1053 0.290807270876224 1384 9903 A bile acid which acts as a detergent. SGTC_72 0744-0168 198.391 µM 0.550775614078581 0.305017014809236 no 1054 0.290893751459306 1448 677577 SGTC_2727 riluzole 51.77 µM 0.548794445313064 0.305653382375157 no 1055 0.291573261356165 1422 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_486 niguldipine 82 µM 0.545640147643974 0.306667780269498 no 1056 0.292656660716646 1415 1236 A calcium channel blocker. SGTC_2214 7179297 48.276 µM 0.545081479303885 0.306847598490155 no 1057 0.292848740003083 1458 769744 SGTC_1570 verbenone 133 µM 0.544063146946785 0.307175488043546 no 1058 0.293199009748406 1467 29025 A natural terpanoid with antifungal properties. SGTC_2236 dapsone 200 µM 0.543492377843891 0.307359335614378 no 1059 0.293395418721839 1410 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_550 4123-0385 25.7 µM 0.542326628219995 0.307734979765744 no 1060 0.293796757408385 1389 5731123 SGTC_1340 1486-1359 257 µM 0.541927662544381 0.307863586399567 no 1061 0.293934169712914 1434 4309068 SGTC_1875 nocodazole 6 µM 0.540722164615255 0.308252322175437 no 1062 0.294349549425805 1430 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1820 st053765 18.6 µM 0.540260115439039 0.308401375795131 no 1063 0.294508830029789 1386 3690829 SGTC_2205 7238770 200 µM 0.537485552031678 0.309297092951469 no 1064 0.295466131116212 1451 279867 SGTC_319 1348-1596 45.5 µM 0.536527405925453 0.309606676746719 no 1065 0.295797050151276 1519 5380505 SGTC_2334 9017922 200 µM 0.536080111241861 0.309751247109528 no 1066 0.295951592509951 1546 3163164 SGTC_3293 9120939 62.045 µM 0.534716216927725 0.310192253777781 no 1067 0.296423052936483 1471 934087 SGTC_1559 coumarin 343 70.1 µM 0.531648986825427 0.311185020438479 no 1068 0.297484564876435 1496 108770 A hepatotoxic, DNA x-linker. SGTC_1255 0566-0045 221 µM 0.530778815938711 0.311466918321857 no 1069 0.297786030789971 1494 2788469 SGTC_1108 betulinic acid 729.144 nM 0.528506653026823 0.312203522189582 no 1070 0.298573865319876 1433 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1244 0416-0015 52.5 µM 0.527820084598835 0.312426246152196 no 1071 0.298812107823426 1445 96201 SGTC_1039 k821-0043 94 µM 0.527002399067204 0.312691594150185 no 1072 0.299095961239607 1523 15992768 SGTC_1925 st057770 10.1 µM 0.526265769463323 0.312930721755502 no 1073 0.299351781455016 1353 5989122 SGTC_2596 sinensetin 100 µM 0.524399467600523 0.313536920247884 no 1074 0.300000363376265 1434 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1236 0330-0013 258 µM 0.524377594348727 0.313544027948011 no 1075 0.300007968592147 1436 4617066 SGTC_3267 9137951 49.47 µM 0.522640887932296 0.314108590444068 no 1076 0.300612090581786 1480 16643986 SGTC_3073 9114972 49.47 µM 0.522203522616577 0.314250836308063 no 1077 0.300764316814789 1501 41905075 SGTC_1403 3909-7815 62.9 µM 0.520988178441344 0.314646251790474 no 1078 0.301187503278219 1481 6615483 SGTC_2666 tannic acid 100 µM 0.520967978425336 0.314652825717668 no 1079 0.301194539249777 1477 16134267 A thiamine antagonist. SGTC_2675 theaflavin digallate 100 µM 0.520837060130325 0.31469543341209 no 1080 0.301240141869977 1461 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1393 3470-5649 58.2 µM 0.518401647208746 0.315488494154113 no 1081 0.302089032833553 1424 4108395 SGTC_11 0438-0307 1.3 µM 0.518065807813499 0.315597922733414 no 1082 0.302206177709008 1535 4011476 SGTC_792 4534-1957 155 µM 0.517081746374786 0.315918658500471 no 1083 0.302549547667713 1471 1717904 SGTC_1405 3909-7894 12 µM 0.515056763810024 0.316579098304031 no 1084 0.303256677277662 1527 7104060 SGTC_2142 5622915 118.518 µM 0.510057309482682 0.318212152636892 no 1085 0.305005656144553 1447 5322196 SGTC_2301 7769476 200 µM 0.506336029827409 0.319429996009899 no 1086 0.306310386915597 1538 977820 SGTC_1420 4'-methoxyflavone 42 µM 0.506307344066565 0.319439391437589 no 1087 0.306320454104411 1506 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.506280766039435 0.319448096624152 no 1088 0.306329781720373 1468 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2904 7225135 42.03 µM 0.505375492442117 0.319744663182951 no 1089 0.306647564354542 1526 4446116 SGTC_2595 hexamethylquercetagetin 100 µM 0.505144132265678 0.319820475005979 no 1090 0.306728803192089 1484 386331 SGTC_2476 5806916 10.51 µM 0.504526421147212 0.320022922709156 no 1091 0.306945750180133 1496 2870194 SGTC_62 0180-0423 3.232 µM 0.502685477650676 0.320626588485612 no 1092 0.307592710765964 1431 30102 YGL099W LSG1 SGTC_955 1216-0110 33 µM 0.502115453478792 0.320813602059636 no 1093 0.307793155207648 1410 3619719 SGTC_197 4544-0043 41.561 µM 0.500051329084521 0.321491180387147 no 1094 0.308519467766973 1474 896523 SGTC_1531 st059297 52.4 µM 0.499839484014795 0.321560755227147 no 1095 0.308594053106361 1493 7566702 SGTC_3248 9135562 49.47 µM 0.497554305124065 0.322311658557568 no 1096 0.309399108910092 1494 17650701 SGTC_1370 2001-0092 44.6 µM 0.496053676795581 0.322805155741345 no 1097 0.309928270304352 1652 790957 SGTC_941 3237-0776 460 µM 0.494708167051176 0.323247906087411 no 1098 0.310403067849925 1574 760008 SGTC_1707 st032323 6.317 µM 0.493633328595836 0.323601769962525 no 1099 0.310782579282437 1477 3132057 YMR211W DML1 SGTC_1363 1636-0063 10.4 µM 0.492941995191145 0.323829458667438 no 1100 0.311026786543759 1498 6072185 SGTC_1147 3809-1045 12.3 µM 0.492341133012623 0.324027404497284 no 1101 0.311239103277762 1452 325925 SGTC_562 3772-2733 112 µM 0.490862445734645 0.324514749645297 no 1102 0.311761869953003 1491 2876874 YIL048W NEO1 SGTC_1044 1222-0021 1.78 µM 0.488255820974358 0.325374571755027 no 1103 0.312684325001806 1524 4306703 SGTC_44 0929-0055 61.211 µM 0.486045673655013 0.326104340800934 no 1104 0.313467391671533 1451 1379590 SGTC_1278 0874-0585 172 µM 0.484523238205583 0.326607421978759 no 1105 0.314007288191939 1529 766306 SGTC_2743 auranofin 4.32 µM 0.483873025826323 0.326822377601827 no 1106 0.314237992441346 1527 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2155 5570423 76 µM 0.482345927104235 0.32732745161622 no 1107 0.314780113300156 1505 797402 SGTC_1805 st050013 60.3 µM 0.481709607136962 0.32753800206693 no 1108 0.315006125188173 1537 4037144 SGTC_1792 st045773 43.6 µM 0.47947835036318 0.328276730592008 no 1109 0.315799183143382 1497 2919270 SGTC_2971 9092186 9.93 µM 0.478772490308385 0.328510568074248 no 1110 0.316050244626493 1397 25236400 SGTC_2468 5987765 72.9 µM 0.478626967250242 0.328558785342495 no 1111 0.316102015064951 1556 26772094 SGTC_2504 purpurogallin 52.29 µM 0.478454761560238 0.32861584725933 no 1112 0.316163282619965 1496 5281571 An antioxidant. SGTC_2715 st079500 56.4 µM 0.478089326449485 0.328736950734993 no 1113 0.316293314300388 1461 28246688 SGTC_611 3453-1652 23.7 µM 0.476313199337371 0.329325806861189 no 1114 0.316925631607115 1576 1560575 SGTC_2308 7584454 197.62 µM 0.476234313058919 0.329351970606208 no 1115 0.316953728259114 1613 893577 SGTC_1854 st056233 32.9 µM 0.475434904430076 0.329617152853811 no 1116 0.317238510379813 1599 5393174 SGTC_321 4534-3890 65.3 µM 0.474242177010116 0.330012967276468 no 1117 0.317663609988205 1573 699746 SGTC_161 4065-0411 162.148 µM 0.474047538940996 0.330077577276383 no 1118 0.31773300372188 1573 1906281 YLR208W SEC13 SGTC_1932 st074806 40.9 µM 0.471897865706388 0.330791496857256 no 1119 0.318499845776836 1598 17251235 SGTC_1518 st038567 90.8 µM 0.470105819288655 0.331387117286524 no 1120 0.319139708392832 1504 77966 SGTC_1329 1447-1697 50.6 µM 0.469257946787541 0.331669072515493 no 1121 0.319442635189101 1508 2840515 SGTC_1055 3448-0672 86 µM 0.469126304656324 0.331712857924661 no 1122 0.319489678936029 1522 748378 SGTC_3321 9137793 26.8275 µM 0.468843453030703 0.331806944808428 no 1123 0.319590768866863 1513 4904192 SGTC_1466 k213-0079 57.5 µM 0.466677241166845 0.332527858157437 no 1124 0.32036540752967 1526 3657981 SGTC_2791 5663188 71.43 µM 0.461690499406433 0.334189793803022 no 1125 0.322151642549514 1608 54690634 SGTC_2987 9018338 71.43 µM 0.460573186180888 0.334562609384909 no 1126 0.322552426423407 1553 5055682 SGTC_1810 st050138 53 µM 0.459677631504932 0.334861548298197 no 1127 0.322873813749954 1577 3444541 SGTC_3029 9088683 49.47 µM 0.459076008282891 0.335062430777453 no 1128 0.323089792342875 1547 25236615 SGTC_3155 9099265 49.47 µM 0.458740129599996 0.335174601471563 no 1129 0.323210396431631 1575 25236499 SGTC_779 1360-0071 233 µM 0.45817654556739 0.335362850107021 no 1130 0.323412804516423 1703 7566 SGTC_3179 9107801 49.47 µM 0.457869907703319 0.335465290818634 no 1131 0.323522953768269 1501 4818259 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.456592251495054 0.335892258198227 no 1132 0.323982074805998 1600 804 An inhibitor of viral and cellular DNA polymerases. SGTC_896 0964-0007 44.5 µM 0.456335237532967 0.33597817278597 no 1133 0.324074464210316 1555 6756758 SGTC_2902 5787006 60.46 µM 0.455732650547989 0.336179639068253 no 1134 0.32429112002873 1519 591003 SGTC_3169 9102970 49.47 µM 0.454342760762564 0.336644508090852 no 1135 0.324791071720905 1577 17027839 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.453281828053683 0.336999520716134 no 1136 0.325172908159052 1593 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2110 5483698 200 µM 0.452269930081885 0.337338260524249 no 1137 0.325537267820581 1554 2848765 YHR062C RPP1 SGTC_691 1548-0686 185 µM 0.451448014918423 0.337613499365902 no 1138 0.325833342098317 1500 46495133 SGTC_2327 6189656 200 µM 0.450843945544659 0.337815842502182 no 1139 0.326051012969235 1662 5349088 SGTC_2639 lactacystin 53 µM 0.450111265489114 0.338061328849263 no 1140 0.326315107083418 1633 3870 A proteasome inhibitor. SGTC_2622 2-methoxyxanthone 59.94 µM 0.449064841326591 0.338412055385556 no 1141 0.32669244110461 1699 71034 A hepatoprotective. SGTC_1835 st008666 49.2 µM 0.448917089757541 0.338461588096098 no 1142 0.326745733694676 1496 690455 SGTC_2659 sanguinarine 24.21 µM 0.445998251105921 0.33944068097968 no 1143 0.327799254617741 1543 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3332 9141069 11.198 µM 0.445670353636262 0.339550738539057 no 1144 0.327917691279485 1509 17332883 SGTC_959 1222-0044 107 µM 0.443992670180276 0.340114060663304 no 1145 0.328523941654803 1647 6083612 SGTC_2488 5268135 45.7 µM 0.443285576824794 0.34035159111829 no 1146 0.328779593442901 1628 1270356 YLR208W SEC13 SGTC_2079 5212404 121 µM 0.442887500964569 0.340485342698295 no 1147 0.328923554267579 1660 758462 SGTC_2014 4013930 200 µM 0.442176391720821 0.340724321921687 no 1148 0.329180784171839 1554 64556 SGTC_3294 9122953 26.2835 µM 0.441778408335939 0.340858098287725 no 1149 0.329324782214709 1518 16459826 SGTC_269 exalamide 29 µM 0.439872852740773 0.341498900353995 no 1150 0.330014599406237 1610 3316 A derivative of salicylamide. SGTC_2074 5212007 75.395 µM 0.439430193354498 0.341647823779247 no 1151 0.330174926381273 1666 758611 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.438346175767989 0.342012622723279 no 1152 0.330567678791367 1616 5393153 SGTC_2648 atorvastatin 78.68 µM 0.437925318797339 0.342154291362455 no 1153 0.33072021058133 1646 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_908 3448-7491 47.7 µM 0.436687131863844 0.342571217949045 no 1154 0.331169131383925 1537 1203031 SGTC_1645 Cervolide 78 µM 0.43410639354907 0.343440829342246 no 1155 0.33210559144775 1563 23173 A fragrance. SGTC_1567 st069303 68.4 µM 0.433898502338246 0.343510916990559 no 1156 0.332181073682022 1569 5581319 SGTC_302 1094-0063 18.9 µM 0.433753065819701 0.343559952101636 no 1157 0.332233883586259 1545 5440289 SGTC_2268 7933382 153.85 µM 0.433712170859462 0.343573740646029 no 1158 0.332248733681942 1548 935025 YOR257W CDC31 SGTC_805 3852-0218 479 µM 0.433275951686455 0.343720833513182 no 1159 0.332407153362436 1528 6615355 SGTC_2730 imipramine 71.33 µM 0.432936533665794 0.343835301454809 no 1160 0.332530438936074 1612 3696 A tricyclic antidepressant. SGTC_2460 5552655 174.22 µM 0.431461165400983 0.344333032237292 no 1161 0.333066541974755 1522 5401989 SGTC_1962 st076595 64.5 µM 0.431172958096624 0.344430293477568 no 1162 0.333171307450543 1578 279619 SGTC_1899 st063254 59.6 µM 0.430433418702216 0.344679912690092 no 1163 0.33344019501254 1505 3093813 SGTC_3177 9107506 49.47 µM 0.429948271110145 0.344843702932496 no 1164 0.333616635305473 1652 8897194 SGTC_2082 5219693 150 µM 0.42938899618478 0.34503255532348 no 1165 0.333820080175139 1548 2834649 SGTC_504 lovastatin 124 µM 0.42894198413572 0.345183527265006 no 1166 0.333982722831292 1531 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_337 1315-0038 354 µM 0.428668657195189 0.345275851681122 no 1167 0.334082186568319 1578 1626437 SGTC_356 1634-0012 32.5 µM 0.428583380764332 0.345304658251959 no 1168 0.334113221066863 1680 735457 SGTC_2589 lobaric acid 100 µM 0.4279010310628 0.345535189784312 no 1169 0.334361588203904 1535 73157 A novel microtubule depolymerizer. SGTC_1026 k007-1105 30.6 µM 0.427466369038826 0.345682070031504 no 1170 0.334519837808029 1574 7066794 SGTC_164 4100-3994 89.624 µM 0.42730187792542 0.345737660647795 no 1171 0.334579732591754 1712 4615967 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.424734499787925 0.346605749703478 no 1172 0.335515115497733 1553 229346 A bile salt which induces apoptosis. SGTC_1104 tacrolimus 29.8 µM 0.424632966365554 0.346640097067002 no 1173 0.335552128577545 1594 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_162 k030-0015 37.8 µM 0.424589838835309 0.346654686900175 no 1174 0.335567850806863 1730 1809920 YMR134W ERG29 SGTC_588 3970-1144 52.9 µM 0.424105596870626 0.34681851920477 no 1175 0.335744401963695 1647 1888707 SGTC_2878 9043973 25.97 µM 0.423994487603659 0.34685611455108 no 1176 0.335784916723665 1676 6465167 SGTC_2973 9094665 17.96 µM 0.423874752573178 0.346896630230888 no 1177 0.335828578909173 1703 25237061 YIL048W NEO1 SGTC_2328 6201408 200 µM 0.423591411694959 0.346992513474677 no 1178 0.335931909895034 1567 2890418 SGTC_928 2764-0428 58.7 µM 0.42269551846252 0.347295750368966 no 1179 0.336258712877419 1632 662578 SGTC_2447 5741742 33.78 µM 0.422675863106398 0.347302404299971 no 1180 0.336265884125774 1665 1776504 SGTC_3255 9139072 49.47 µM 0.421529672562675 0.347690505710846 no 1181 0.336684174221395 1590 17646060 SGTC_1068 loratadine 26.9 µM 0.42053212976021 0.34802840480261 no 1182 0.3370483814374 1572 3957 A H1 histamine antagonist. SGTC_2049 5262831 67.185 µM 0.418172502342732 0.348828164789919 no 1183 0.337910499396424 1606 763417 SGTC_3006 9075424 71.4286 µM 0.417835746988731 0.348942357807802 no 1184 0.338033606465003 1544 7465181 SGTC_3180 9109287 49.47 µM 0.417252327555407 0.349140226466792 no 1185 0.338246927089 1597 18891271 SGTC_2310 7668677 200 µM 0.416875424800682 0.349268076113827 no 1186 0.338384764875366 1641 2197143 SGTC_2389 9091542 195.52 µM 0.416595363731942 0.349363087052354 no 1187 0.33848720054126 1574 3626624 YOL127W RPL25 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.416482018372563 0.349401542238586 no 1188 0.338528661351987 1541 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1259 0671-0132 43 µM 0.415247012419511 0.349820648332932 no 1189 0.338980543240004 1586 X1259 SGTC_1082 camptothecin 424.86 nM 0.414316050055215 0.350136696593371 no 1190 0.339321330505923 1424 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2926 9010726 65.15 µM 0.414141906980698 0.35019582718248 no 1191 0.339385091770719 1565 2994293 SGTC_3008 9078912 71.4286 µM 0.413688495597005 0.35034980085499 no 1192 0.339551126737249 1581 16648731 SGTC_3104 9120930 49.47 µM 0.413680551231307 0.350352498896226 no 1193 0.339554036166664 1615 17014836 SGTC_301 4119-0100 24.5 µM 0.410826893260431 0.351322137083797 no 1194 0.34059973592786 1629 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1015 4130-4525 82 µM 0.410541965376325 0.35141900538571 no 1195 0.340704212904069 1555 1363237 SGTC_135 0933-0004 26.348 µM 0.407764395355636 0.352363813971548 no 1196 0.341723327787097 1557 21230617 YGL099W LSG1 SGTC_1698 5-fluorocytosine 1.055 µM 0.407426288989576 0.352478885424463 no 1197 0.341847460966886 1722 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2204 7233102 200 µM 0.40525270198948 0.353218968182135 no 1198 0.342645884729162 1656 2172480 SGTC_366 0181-0206 4.31 µM 0.405055507583052 0.353286138259039 no 1199 0.342718355014318 1783 274874 SGTC_1206 3978-0017 132 µM 0.404246847108395 0.353561639018161 no 1200 0.343015603755325 1705 3873677 SGTC_1668 st014914 51.6 µM 0.40386429165528 0.353691997738549 no 1201 0.343156257988026 1617 2839556 SGTC_2739 tacrine 100.86 µM 0.399604823135377 0.355144600457541 no 1202 0.344723801728036 1629 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2413 inermin 26.06 µM 0.3979737642237 0.35570139824187 no 1203 0.345324762490391 1765 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2832 7992762 51.95 µM 0.397224350096048 0.355957330563708 no 1204 0.345601013713427 1463 2985177 SGTC_1133 3473-0247 50 µM 0.394697832904067 0.356820638935208 no 1205 0.34653295114498 1559 711311 SGTC_2844 9010103 25.97 µM 0.394693285243395 0.356822193529197 no 1206 0.346534629446258 1626 2480525 SGTC_2690 usnic acid 100 µM 0.394631970732318 0.356843153805916 no 1207 0.346557257686827 1770 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1690 st023502 41.2 µM 0.394235672868007 0.356978638078101 no 1208 0.346703525393857 1722 24207482 SGTC_1575 cyproterone acetate 48 µM 0.394169921760187 0.357001118473326 no 1209 0.346727795370657 1568 9880 An androgen receptor antagonist and liver toxin. SGTC_2796 7949634 45.45 µM 0.393354755706237 0.3572798660947 no 1210 0.34702874078282 1604 2971588 SGTC_1964 st076914 61 µM 0.393292207698022 0.357301257656741 no 1211 0.347051836430309 1627 24208661 SGTC_2979 9012552 45.46 µM 0.392569123807215 0.357548586547017 no 1212 0.347318874021989 1667 17100905 SGTC_169 k015-0017 16.025 µM 0.391058241032121 0.358065572954875 no 1213 0.347877093259326 1714 1840002 SGTC_123 0083-0120 66.675 µM 0.389119483455348 0.358729348792282 no 1214 0.348593880668616 1577 16001701 SGTC_1648 st011736 69.8 µM 0.388311557135306 0.359006086083965 no 1215 0.34889274281917 1714 2855514 SGTC_2572 astragaloside iv 100 µM 0.388155728979124 0.359059470090657 no 1216 0.348950396415234 1669 45006101 An anti-inflammatory agent. SGTC_1368 1852-0141 284 µM 0.385618761889575 0.359928977229502 no 1217 0.349889518001573 1654 2838987 SGTC_2944 9067346 25.62 µM 0.384627280639396 0.360268989828931 no 1218 0.350256789590382 1679 6473075 SGTC_479 n-linoleoylglycine 10 µM 0.383900972029125 0.360518135893545 no 1219 0.350525922944288 1646 6433346 An anti-infammatory. SGTC_342 k048-0088 23.3 µM 0.381617915371016 0.361301679411233 no 1220 0.351372396828137 1602 6820570 SGTC_1629 st005085 44.9 µM 0.378186730176561 0.362480354011685 no 1221 0.352645941252952 1580 24207091 SGTC_1475 4092-1048 11.7 µM 0.378121500668052 0.362502774207615 no 1222 0.352670168384662 1637 2881759 SGTC_2402 5553605 200 µM 0.377896649289678 0.362580062045555 no 1223 0.352753685841839 1722 6758546 SGTC_152 4469-0003 551.229 µM 0.376752629368939 0.362973381022186 no 1224 0.353178723623639 1706 697280 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.376453632585367 0.363076201252545 no 1225 0.353289840136978 1770 23847180 SGTC_1179 1021-1431 9.29 µM 0.376311987771693 0.36312491409304 no 1226 0.353342484126247 1686 2840958 SGTC_1660 st012960 28.1 µM 0.376012220166745 0.363228013989739 no 1227 0.353453905594665 1660 24207266 SGTC_2935 9038016 29.96 µM 0.375340711774156 0.363459003673655 no 1228 0.353703546014362 1735 6463195 SGTC_2052 5265182 7.135 µM 0.374379389702581 0.36378977169672 no 1229 0.354061037269192 1762 1239884 SGTC_2186 6124449 200 µM 0.374097147731002 0.363886903727423 no 1230 0.354166020337329 1708 3834182 YLR033W RSC58 SGTC_2407 paclitaxel 400 µM 0.372034381048732 0.364597058801148 no 1231 0.354933625655365 1769 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_296 1222-0039 74.9 µM 0.370788472127817 0.365026217104283 no 1232 0.355397544107297 1611 5984176 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.369005418517752 0.365640691153038 no 1233 0.356061842982937 1745 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3235 9132602 49.47 µM 0.368883055677182 0.36568287237127 no 1234 0.356107446838971 1705 4912240 SGTC_1612 st002233 45.4 µM 0.368625153384297 0.365771782400135 no 1235 0.356203572131693 1679 1035021 SGTC_41 0478-0632 82.643 µM 0.368330977412539 0.365873206331417 no 1236 0.356313228500147 1816 3750424 SGTC_2187 6125751 200 µM 0.367982294490293 0.365993434928425 no 1237 0.356443218144064 1694 874498 SGTC_150 3970-0969 77.2 µM 0.367596902712344 0.366126336336757 no 1238 0.35658691232374 1706 6615640 SGTC_2291 7917025 104.35 µM 0.367406928867818 0.366191854261851 no 1239 0.356657751985538 1611 2964612 SGTC_3245 9134821 49.47 µM 0.366119825337273 0.366635851468634 no 1240 0.357137832278702 1586 17014901 SGTC_1019 4262-0212 3.4 µM 0.365426469792075 0.366875104330985 no 1241 0.357396542699961 1800 4677213 SGTC_502 l-744,832 89.3 µM 0.364452220926249 0.367211371078618 no 1242 0.35776017305724 1786 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_992 3909-8734 162 µM 0.364403576358386 0.367228163660939 no 1243 0.35777833262852 1654 4288319 SGTC_1289 0976-0073 69.1 µM 0.363479830679592 0.367547097905764 no 1244 0.358123238467238 1714 3391136 SGTC_590 k048-0076 22.4 µM 0.363453152885747 0.367556310091803 no 1245 0.358133201076881 1766 6832814 SGTC_2332 7982454 138.89 µM 0.362745645807927 0.367800649200595 no 1246 0.358397449192914 1672 2981748 SGTC_2024 5144227 134 µM 0.361950994055215 0.368075147711463 no 1247 0.358694326000429 1755 3475211 SGTC_706 4262-0057 46.9 µM 0.361792692648327 0.368129838207989 no 1248 0.358753476598691 1634 883298 SGTC_2373 9071805 200 µM 0.359944279735628 0.368768631585344 no 1249 0.359444401388744 1837 10149009 SGTC_2786 7743617 45.45 µM 0.359291777602275 0.368994216642938 no 1250 0.359688412386433 1590 583674 SGTC_2114 5491910 81.25 µM 0.35886653624891 0.369141256697177 no 1251 0.359847467288362 1756 2849228 SGTC_811 0416-0114 265 µM 0.358052100082995 0.369422926068706 no 1252 0.360152162190221 1683 6612453 SGTC_1402 3909-7673 35.9 µM 0.357579523344032 0.369586396925077 no 1253 0.360329002217882 1656 5328014 SGTC_3240 9133527 49.47 µM 0.357242801829215 0.369702887958739 no 1254 0.360455022935163 1680 17617455 SGTC_1109 tnp00067 928.257 nM 0.355947335892068 0.370151174393181 no 1255 0.360940002662443 1664 676295 SGTC_1354 1498-1681 81 µM 0.355580248922913 0.370278234242077 no 1256 0.36107746862165 1708 5754243 SGTC_314 1671-0008 2.74 µM 0.353865488013745 0.370871951908852 no 1257 0.361719846124342 1704 3913060 SGTC_995 3931-2021 34.6 µM 0.353248062506107 0.371085804285838 no 1258 0.361951239383132 1727 730143 SGTC_2444 5485484 36.41 µM 0.352647492653157 0.37129385671614 no 1259 0.362176364055057 1758 6790631 SGTC_1719 st032227 49.2 µM 0.352521930257462 0.371337359429315 no 1260 0.362223437370469 1630 3125804 SGTC_3192 9110362 49.47 µM 0.352272679313305 0.371423720506681 no 1261 0.362316887669252 1728 16649480 SGTC_554 4483-2211 187 µM 0.3508114101407 0.37193015471469 no 1262 0.362864918265304 1712 747107 SGTC_2506 ethyl hematommate 54.16 µM 0.349674968312309 0.37232416631156 no 1263 0.363291320763181 1626 3940691 An allergen. SGTC_1218 1348-1416 30.7 µM 0.3494830766169 0.372390709584362 no 1264 0.363363336873285 1682 6787668 SGTC_183 3914-0051 30.55 µM 0.3485756394882 0.37270543781499 no 1265 0.363703959423834 1846 1596232 SGTC_1075 aripiprazole 15.2 µM 0.346245223515126 0.373514089644396 no 1266 0.364579215343931 1691 60795 An atypical antipschotic. YIL048W NEO1 SGTC_54 0159-0055 9 µM 0.346140765458273 0.373550349552956 no 1267 0.36461846419975 1819 3319099 SGTC_2303 7774051 200 µM 0.344520526854963 0.374112916578568 no 1268 0.365227430814393 1798 2953184 SGTC_1881 5652484 16 µM 0.343009488524591 0.374637809647081 no 1269 0.365795660959754 1820 2255129 SGTC_207 4185-0010 4.486 µM 0.341283734252725 0.375237573323314 no 1270 0.366444995918241 1781 3761753 SGTC_2351 9026858 72.31 µM 0.341152876428559 0.375283063600675 no 1271 0.366494248309619 1645 1409300 SGTC_1915 st067105 30.6 µM 0.340988907726415 0.375340066704297 no 1272 0.366555966108144 1661 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3039 9090270 49.47 µM 0.340231686953332 0.375603346956999 no 1273 0.366841028652874 1855 17173750 SGTC_871 0574-0004 149 µM 0.338019246856023 0.376372928107522 no 1274 0.36767434184046 1726 9551173 SGTC_976 1348-1067 47.6 µM 0.337275333281533 0.376631803636834 no 1275 0.367954676321363 1711 5310671 YGL099W LSG1 SGTC_429 1112-0049 25.5 µM 0.334689780494415 0.377531984676013 no 1276 0.368929555641047 1657 2836170 SGTC_2288 7946289 167.31 µM 0.330920064106794 0.378845633515599 no 1277 0.370352433030523 1849 1246052 SGTC_3070 9117005 49.47 µM 0.330900832615071 0.378852338798067 no 1278 0.370359696515468 1798 8779016 SGTC_616 4092-0450 108 µM 0.328275128771426 0.379768162404869 no 1279 0.371351823752529 1773 787165 SGTC_1556 plumbagin 1.48 µM 0.327288148478053 0.38011258767985 no 1280 0.371724977714928 1762 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_673 1082-0474 110 µM 0.326341396995619 0.380443063726572 no 1281 0.372083035404756 1704 3098046 SGTC_2368 9071271 200 µM 0.324627214108725 0.381041643715459 no 1282 0.372731613963788 1680 27209959 SGTC_1098 clofazimine 15.1 µM 0.323768184123586 0.381341717836226 no 1283 0.373056772606167 1817 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2431 5490079 200 µM 0.323128974783437 0.381565051089583 no 1284 0.373298783796557 1700 5722345 SGTC_2235 salicylic acid 500 µM 0.323083169224967 0.381581056601729 no 1285 0.373316128169844 1780 338 A COX inhibitor and kinase inhibitor. SGTC_1246 0422-0085 105 µM 0.322445184623911 0.381804004085068 no 1286 0.373557729081975 1879 264295 SGTC_3085 9117376 49.47 µM 0.321619746119399 0.382092516616716 no 1287 0.373870391400224 1785 16480349 SGTC_2314 7727897 200 µM 0.321468557308978 0.382145368194642 no 1288 0.373927668197123 1671 900724 SGTC_2806 7952793 58.44 µM 0.320383425314227 0.382524765804405 no 1289 0.37433884429699 1775 2972490 SGTC_447 ml7 120 µM 0.318655444773719 0.383129156943183 no 1290 0.374993902249227 1819 4216 Selective myosin light chain kinase inhibitor. SGTC_1870 st057514 26.5 µM 0.318347033432075 0.38323705912792 no 1291 0.375110855508356 1729 5393161 SGTC_15 0266-0086 27.098 µM 0.317522035139367 0.383525741262405 no 1292 0.37542376111666 1849 1712902 YIL048W NEO1 SGTC_1493 4348-0038 111 µM 0.31577039707356 0.384138886001631 no 1293 0.376088394513299 1803 800424 SGTC_2802 7925815 54.55 µM 0.314616843019066 0.384542835472974 no 1294 0.376526294632318 1714 1262923 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.313987150394303 0.384763393033573 no 1295 0.376765399057621 1715 4174840 SGTC_488 nitrendipine 139 µM 0.313726447156955 0.384854718460155 no 1296 0.376864406117346 1819 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1453 4237-0541 195 µM 0.312912302913589 0.385139957676134 no 1297 0.377173645129482 1883 739892 SGTC_2073 5212005 126 µM 0.312891255836525 0.385147332442189 no 1298 0.377181640553647 1894 691789 SGTC_1167 k781-0610 148 µM 0.311125711363928 0.385766115991541 no 1299 0.377852527815339 1761 4525169 SGTC_260 nsc-65238 3.989 µM 0.308548828051178 0.386669777116156 no 1300 0.37883237593448 1822 3246252 SGTC_2433 5607874 27.82 µM 0.307668693532706 0.386978563693091 no 1301 0.379167221923228 1721 2252428 SGTC_1512 0259-0544 12.2 µM 0.307262403574797 0.387121130695233 no 1302 0.379321824996611 1809 18476 SGTC_712 r015-0009 80.6 µM 0.306141637988022 0.387514485833328 no 1303 0.379748403171868 1838 6813872 YLR060W FRS1 SGTC_1461 k072-0203 53.8 µM 0.303079808773376 0.388589683807103 no 1304 0.380914520591675 1769 5418714 SGTC_1680 diphenhydramine 100 µM 0.302973839261969 0.38862691160855 no 1305 0.380954899204644 1762 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_20 0481-0013 4.944 µM 0.302901891979859 0.388652187755268 no 1306 0.380982314729384 1734 182045 SGTC_190 3970-0790 3.722 µM 0.301945630505759 0.388988181320397 no 1307 0.381346755028873 1863 2832352 SGTC_188 3229-0966 278.469 µM 0.300946315930861 0.389339390824108 no 1308 0.381727715725159 1902 5722370 SGTC_674 0498-0004 451 µM 0.300767481151867 0.389402251924307 no 1309 0.38179590357445 1735 4231473 SGTC_1065 prochlorperazine maleate 2.48 µM 0.300125483753067 0.389627940267264 no 1310 0.382040720737514 1772 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2154 5570129 200 µM 0.299716124530333 0.389771866216964 no 1311 0.3821968490651 1831 673366 SGTC_1889 st059080 5.18 µM 0.297933677079923 0.390398730011701 no 1312 0.382876891946173 1919 176925 Isolated from Daphnopsis sellowiana. SGTC_1739 st037196 92.5 µM 0.296951864380651 0.390744142734305 no 1313 0.383251629485379 1915 612214 SGTC_750 4073-0104 132 µM 0.296707499343288 0.390830126507828 no 1314 0.38334491554635 1808 22330957 SGTC_1704 st028805 70.8 µM 0.295918734695526 0.391107702451554 no 1315 0.383646071634622 1764 2876101 SGTC_1564 D-Arginine 115 µM 0.294974032118155 0.391440227866287 no 1316 0.384006858468168 1692 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.29444145253289 0.391627725295594 no 1317 0.384210297725717 1802 688788 SGTC_3047 9092122 49.47 µM 0.292860177705954 0.39218456956951 no 1318 0.384814514253963 1752 17173831 SGTC_2412 st077135 33.4 µM 0.292745970879424 0.392224795949282 no 1319 0.384858164360306 1861 13258915 SGTC_1173 0443-0020 122 µM 0.292532120455439 0.392300122287923 no 1320 0.384939902398463 1760 5331295 SGTC_382 3229-0966 23.2 µM 0.291979502976314 0.392494794086215 no 1321 0.385151147857031 1878 5722370 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.29132274567783 0.392726186433676 no 1322 0.385402246485166 1892 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3203 9113543 49.47 µM 0.290739583772241 0.392931681033958 no 1323 0.385625247593897 1836 17018012 SGTC_1985 st071382 65.5 µM 0.290571380321102 0.392990958116103 no 1324 0.385689575621638 1790 6123237 SGTC_874 0599-0792 117 µM 0.288128431872994 0.393852163977322 no 1325 0.386624214776364 1954 765305 SGTC_2019 4016004 108 µM 0.287809983151814 0.393964464179047 no 1326 0.386746097559844 1747 45595336 SGTC_138 0850-0259 40.9225 µM 0.285993980765274 0.394605041453627 no 1327 0.387441365878038 1848 6813004 SGTC_2300 7976697 71.57 µM 0.285224906861303 0.394876410866482 no 1328 0.387735919815572 1739 2236109 SGTC_230 MPP+ 141.667 µM 0.285211881659072 0.394881007277255 no 1329 0.387740909001793 1741 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_946 3434-1334 87.4 µM 0.285058337106622 0.39493519209407 no 1330 0.387799724254408 1869 4047976 SGTC_839 0122-0028 230 µM 0.284396624311257 0.395168729226436 no 1331 0.388053222828679 1829 759448 SGTC_3233 9132340 49.47 µM 0.282423580701602 0.39586529528676 no 1332 0.388809367924548 1768 17682950 SGTC_1013 4112-3890 241 µM 0.279297912815889 0.396969465619659 no 1333 0.390008103957828 1784 705171 SGTC_1196 1588-0294 184 µM 0.279224181941773 0.396995521726962 no 1334 0.390036393430013 1770 6144269 SGTC_2246 7293507 91.5585 µM 0.278962493977722 0.397088004603325 no 1335 0.390136804025618 1960 887656 SGTC_1521 st012942 49.4 µM 0.278602123729501 0.397215372156482 no 1336 0.390275091358677 1971 24207259 SGTC_572 0960-0087 17.7 µM 0.275856385358873 0.398186171931275 no 1337 0.391329186985238 1737 6796365 SGTC_2029 5175081 200 µM 0.275628027471228 0.398266940004605 no 1338 0.391416890209514 1819 1380876 SGTC_2552 juarezic acid 87.02 µM 0.273399642224088 0.399055327556881 no 1339 0.392273013888468 1918 1549512 SGTC_2876 9059903 25.97 µM 0.2724038014699 0.399407782627546 no 1340 0.392655775018452 1848 6916095 SGTC_2597 laccaic acid a 100 µM 0.271508601948975 0.399724688034823 no 1341 0.392999942350641 1822 5491415 A textile dye. SGTC_2518 prenyletin 46.28 µM 0.271028527406008 0.399894664213199 no 1342 0.393184545711948 1943 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1042 0350-0096 82 µM 0.269835040102606 0.400317314913263 no 1343 0.393643582127925 1776 3122515 SGTC_446 go6976 132 µM 0.267885056266364 0.401008115422357 no 1344 0.394393898404302 1966 3501 A protein kinase C inhibitor. SGTC_1313 1220-0047 237 µM 0.267838702580014 0.401024540437108 no 1345 0.394411739192278 1881 3528706 SGTC_3311 9131146 2.8755 µM 0.267472922096664 0.401154157619261 no 1346 0.394552529981747 1834 4900406 YPR165W RHO1 SGTC_1349 flufenamic acid 69 µM 0.267084527420129 0.401291800227534 no 1347 0.394702040169017 1816 3371 A non-steroidal anti-inflammatory. SGTC_1427 4048-4900 550 nM 0.264660240877421 0.402151215736431 no 1348 0.395635604363171 1961 24132586 SGTC_2810 7959871 45.46 µM 0.262525370096986 0.402908424700796 no 1349 0.396458214275712 1900 2974535 SGTC_3106 9121286 49.47 µM 0.262120749654629 0.403051979093253 no 1350 0.396614175001048 1942 15943471 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.260037901668699 0.403791154499912 no 1351 0.397417268826987 1740 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1868 st057644 42.7 µM 0.259856867242166 0.403855417515185 no 1352 0.397487091749541 1852 688665 SGTC_1005 4092-0690 4.4 µM 0.259530912377692 0.403971130460798 no 1353 0.397612817119381 1806 1529343 SGTC_1637 st007924 17.4 µM 0.258415727894649 0.404367080923501 no 1354 0.398043039807522 1819 683336 SGTC_1992 st073643 23.3 µM 0.258223593468627 0.404435308882353 no 1355 0.398117175137343 1817 3161292 SGTC_2995 9067767 71.4286 µM 0.258119761459974 0.404472181391926 no 1356 0.398157240390369 1862 11673567 SGTC_2109 5483026 200 µM 0.256507287807383 0.405044906874342 no 1357 0.398779576894397 1849 759335 SGTC_442 cape 100 µM 0.253666981565601 0.406054233407791 no 1358 0.399876422366577 1974 5281787 SGTC_187 1488-2104 32.728 µM 0.252297476745151 0.406541122030646 no 1359 0.40040556916657 1939 2852859 SGTC_3000 9075062 71.4286 µM 0.251978167288394 0.40665466426209 no 1360 0.40052896970054 1845 17057871 SGTC_1965 Pectolinarigenin 58.4 µM 0.250851717512237 0.407055277560306 no 1361 0.400964377410124 1848 5320438 An anti-inflammatory. SGTC_112 phenothiazine 287.218 µM 0.24987592225818 0.407402390359172 no 1362 0.401341651967836 1999 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1021 4476-0760 85.3 µM 0.249851576440051 0.407411051657185 no 1363 0.401351066040059 1782 746768 SGTC_73 0327-0325 16.231 µM 0.24983193841635 0.407418038137482 no 1364 0.401358659738012 2007 53298 SGTC_2848 9016370 25.97 µM 0.249568958077755 0.407511599622831 no 1365 0.401460353460803 2018 7894410 SGTC_784 4579-0127 173 µM 0.249124988783156 0.407669564186608 no 1366 0.401632050222288 1995 1948547 SGTC_1776 st049249 45.9 µM 0.246989566021822 0.408429558317623 no 1367 0.40245814953763 1821 1822314 SGTC_1061 3448-9325 110 µM 0.246413647600473 0.408634586030367 no 1368 0.402681021318736 1991 723482 SGTC_3019 9081971 49.47 µM 0.243898905070519 0.40953012996124 no 1369 0.403654558602482 1988 16451803 SGTC_335 4077-0256 27.6 µM 0.243630111400653 0.409625880121721 no 1370 0.403758652666803 1939 3121989 SGTC_1047 2043-3044 82 µM 0.243569107518459 0.409647611784168 no 1371 0.403782278212856 1827 669592 SGTC_736 0958-0254 92.6 µM 0.243093304695836 0.409817118490547 no 1372 0.403966558878135 1912 6812352 SGTC_460 trequinsin 123 µM 0.242507319120029 0.410025901414632 no 1373 0.404193543128225 1966 5537 A vasodilator. SGTC_854 0422-0053 192 µM 0.242148946817459 0.410153599755699 no 1374 0.40433237621501 1932 3596728 SGTC_1513 0337-0559 19 µM 0.239900604709638 0.410954965482755 no 1375 0.405203656027685 1809 775073 SGTC_1230 0170-0365 3.77 µM 0.237466119408922 0.411823096476089 no 1376 0.406147600174564 2001 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2266 7929956 200 µM 0.237127503878524 0.411943880175617 no 1377 0.406278937879847 1844 2967153 SGTC_1687 st020778 55.3625 µM 0.236747949958713 0.412079276459262 no 1378 0.406426166760309 1912 4259299 SGTC_1983 st071813 46.9 µM 0.234317809040215 0.412946415283479 no 1379 0.407369130558186 1889 11838595 SGTC_539 4859-0462 2.54 µM 0.233399519221353 0.413274196334365 no 1380 0.407725593235997 2020 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3079 9117512 49.47 µM 0.232408048300706 0.413628167052955 no 1381 0.408110549204683 1934 7185044 SGTC_331 k048-0133 24.5 µM 0.230287154185816 0.414385594972444 no 1382 0.408934320934131 1864 6813582 SGTC_826 1683-5028 118 µM 0.230240769666157 0.414402163692028 no 1383 0.408952341551218 1900 722377 SGTC_3046 9092212 49.47 µM 0.230171350195021 0.414426960864841 no 1384 0.408979311721305 1913 25236637 SGTC_2229 7354935 190 µM 0.226679071796605 0.415674867898318 no 1385 0.410336650912204 1981 318112 SGTC_303 1348-1668 34.2 µM 0.226026868023536 0.415908016632871 no 1386 0.410590261675826 1934 5380509 SGTC_338 4055-0136 114 µM 0.223415005118576 0.416841996930746 no 1387 0.411606263526476 1860 2900563 SGTC_364 0083-0097 67.7 µM 0.220195840835007 0.417993788656866 no 1388 0.41285931783782 1897 5207356 SGTC_1024 4507-0395 26 µM 0.220151219199537 0.418009758895441 no 1389 0.412876693006797 1905 4201836 SGTC_1362 1611-0397 101 µM 0.21970103208951 0.418170889986648 no 1390 0.413052000406868 1893 27816 SGTC_2900 5328528 85.29 µM 0.219221285170632 0.418342616249369 no 1391 0.413238837778884 1922 795359 SGTC_909 3448-9333 149 µM 0.218049138048282 0.418762253809317 no 1392 0.413695412891934 1848 3344074 SGTC_1172 0370-0043 85 µM 0.217941281614352 0.418800871883031 no 1393 0.413737431036476 1956 376585 SGTC_1241 0364-0022 50.8 µM 0.2154808229398 0.419682052695105 no 1394 0.414696230986968 1954 4563895 SGTC_1176 0848-0131 83.3 µM 0.213681411769937 0.420326743387596 no 1395 0.415397753907524 2063 6769040 SGTC_1283 0922-0125 16.4 µM 0.213017322419238 0.420564726561635 no 1396 0.41565672570812 1988 3360884 SGTC_1747 st037496 66.6 µM 0.211017006930238 0.421281735082262 no 1397 0.416437000269967 1922 723305 SGTC_2959 9079155 11 µM 0.211004931505797 0.4212860642859 no 1398 0.416441711603527 1941 16189457 SGTC_2656 pseudo-anisatin 100 µM 0.210712750240499 0.421390818136718 no 1399 0.416555712364006 1952 6708809 A neurotoxin. SGTC_2712 st079126 47.7 µM 0.209303455829972 0.421896161319823 no 1400 0.417105677081455 1931 3152970 SGTC_1787 fluconazole 80 µM 0.208189244445498 0.422295785063847 no 1401 0.417540603147327 1956 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2234 tolnaftate 200 µM 0.207369793755171 0.422589740836401 no 1402 0.417860535476367 2035 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2031 5180455 200 µM 0.206356237904264 0.422953386213356 no 1403 0.418256326100108 1957 29949 SGTC_1067 clotrimazole 1.36 µM 0.206136671572546 0.423032171276603 no 1404 0.418342077039955 1917 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2790 5423970 71.43 µM 0.205063661808694 0.423417234191596 no 1405 0.418761193382584 2022 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1732 st034308 51.822 µM 0.204478968997325 0.423627089303343 no 1406 0.418989612553024 1857 830119 SGTC_1515 3460-0031 42.1 µM 0.201614160552956 0.424655624499157 no 1407 0.420109187019566 2001 2876596 SGTC_1738 st035555 74 µM 0.200658969206763 0.424998675618718 no 1408 0.420482622465593 1954 5331140 SGTC_3062 9077494 49.47 µM 0.199370739306405 0.425461425414417 no 1409 0.420986373826221 2012 16459633 SGTC_810 3825-7150 143 µM 0.198821276130614 0.42565883138073 no 1410 0.421201276146829 2097 22330411 YGL099W LSG1 SGTC_3196 9111891 49.47 µM 0.197737055049753 0.426048414761692 no 1411 0.42162539817509 2043 18891510 SGTC_2939 9044578 71.43 µM 0.197597766358635 0.426098469351152 no 1412 0.421679891267956 1933 2653634 SGTC_2988 9073640 71.4286 µM 0.197141652380492 0.426262386161936 no 1413 0.421858344540364 1982 9102229 SGTC_451 chloral hydrate 100 µM 0.196204247778651 0.426599307652503 no 1414 0.422225151715483 1966 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_540 1187-0821 17.3 µM 0.195044004929737 0.427016395711603 no 1415 0.422679249077189 1872 847520 SGTC_262 fenpropimorph 62.5 µM 0.193626487802342 0.427526080320627 no 1416 0.423234178206463 2006 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_428 3448-4153 16.5 µM 0.192062355605626 0.428088622433295 no 1417 0.423846680891072 1837 3834874 SGTC_3350 9150499 3.57 µM 0.191951554009105 0.428128477924673 no 1418 0.423890076979741 2012 4910996 YPR165W RHO1 SGTC_2179 6298986 200 µM 0.190599979817447 0.428614699977502 no 1419 0.424419503002596 2085 738374 SGTC_390 dec-rvkr-cmk 16.7 µM 0.190405873985566 0.428684537495802 no 1420 0.424495547549967 1994 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1392 3455-1037 33.9 µM 0.189767498392389 0.428914234983126 no 1421 0.424745662794671 2034 981132 SGTC_3092 9117248 49.47 µM 0.189201858489071 0.429117781156626 no 1422 0.424967305554278 2045 17141857 SGTC_2062 5245942 200 µM 0.188504373410157 0.429368797916379 no 1423 0.425240643744019 2080 1376160 SGTC_1399 3562-5772 25 µM 0.188292800253303 0.429444946283072 no 1424 0.425323564490106 1991 23847490 SGTC_2709 st078560 56 µM 0.18811009907542 0.429510705302071 no 1425 0.425395172252619 2072 17250903 SGTC_2585 alliin 100 µM 0.187229136987179 0.429827814438434 no 1426 0.425740490374716 2007 87310 A garlic compound which reacts with lipids. SGTC_1328 1441-0025 69.2 µM 0.187173265438623 0.429847927364575 no 1427 0.425762392739281 1992 4562601 SGTC_1028 k015-0029 4.8 µM 0.185777717033684 0.430350362959532 no 1428 0.426309539776478 2008 4588309 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.185685607558183 0.430383528866551 no 1429 0.42634565776947 1960 390807 SGTC_2651 TUB2.036 5 µM 0.185355007002587 0.430502572424641 no 1430 0.426475298036252 2079 15992207 YFL037W TUB2 SGTC_3058 9093861 49.47 µM 0.185295992606654 0.430523823155452 no 1431 0.426498440521331 2037 17217477 SGTC_2912 7964298 10.93 µM 0.184397186553827 0.430847502668808 no 1432 0.426850938390766 1952 2975850 SGTC_2201 6605497 169.863 µM 0.182606998557898 0.431492326320329 no 1433 0.427553196313432 2062 670741 SGTC_808 0711-0032 135 µM 0.182595553226051 0.431496449504959 no 1434 0.427557686848223 2095 4252555 SGTC_128 0906-2981 13.371 µM 0.180352362240592 0.432304703345612 no 1435 0.428437975215247 2096 6740226 SGTC_1300 1094-0077 113 µM 0.179985694978046 0.432436845847953 no 1436 0.428581899277812 1958 5532636 SGTC_1897 st060201 15 µM 0.179044571995241 0.43277604988971 no 1437 0.428951351864359 1913 611878 SGTC_858 0438-0351 2.77 µM 0.177224614153585 0.4334321481144 no 1438 0.429665981189878 1976 2799119 SGTC_2767 sibutramine 71.45 µM 0.176660547100335 0.43363553268075 no 1439 0.429887516114149 2094 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_88 0180-0332 8.668 µM 0.176023313532256 0.433865319894347 no 1440 0.430137813428699 2060 3101745 SGTC_2325 6158266 200 µM 0.175426627724046 0.43408050580146 no 1441 0.430372209550001 1980 3623240 SGTC_1415 3966-0071 78.1 µM 0.174257153597196 0.434502315949115 no 1442 0.430831685237999 2075 2893185 SGTC_2962 9082311 13.18 µM 0.172695078877759 0.435065846941659 no 1443 0.431445556080469 1976 16459453 SGTC_3258 9138477 49.47 µM 0.170921440553695 0.435705861076997 no 1444 0.432142768806593 2074 4970355 SGTC_580 1123-0028 41 µM 0.170806699983228 0.43574727081964 no 1445 0.432187880336776 2088 1677248 YPR107C YTH1 SGTC_1764 st044502 93.5 µM 0.17078218081388 0.435756119851609 no 1446 0.432197520435314 1998 8407 SGTC_563 tetrahydrosecaminediol 614 µM 0.17046140373257 0.435871892095657 no 1447 0.432323642725812 2101 334274 A psychoactive constituent of the cannabis plant. SGTC_2728 chlorpromazine 9.18 µM 0.169384065046026 0.436260756540131 no 1448 0.432747278325881 2107 2726 A thorazine and dopamine antagonist. SGTC_2128 5255449 168.493 µM 0.168683662072813 0.43651359944698 no 1449 0.433022735197047 2035 736008 SGTC_3045 9092950 49.47 µM 0.166502880922496 0.437301019125788 no 1450 0.433880608085031 2136 44120432 SGTC_201 4262-0159 12.803 µM 0.165010274406544 0.43784010139276 no 1451 0.434467947554481 2106 1341029 SGTC_2477 5967686 25.23 µM 0.16338235590178 0.43842818559445 no 1452 0.435108697084146 2001 776118 SGTC_47 0149-0135 24.25 µM 0.163127414397532 0.438520295348252 no 1453 0.435209057664995 2037 5239155 SGTC_1299 1079-1439 3.74 µM 0.162702585796558 0.438673792298363 no 1454 0.435376305475304 1993 323161 SGTC_2176 5809774 33.9695 µM 0.162132947386572 0.438879625678932 no 1455 0.43560058058785 2139 2870539 SGTC_2013 4024628 200 µM 0.162100937083207 0.438891192786357 no 1456 0.435613184135658 2053 5230760 SGTC_3115 9123671 49.47 µM 0.161917596937939 0.438957444808648 no 1457 0.435685372661327 2157 3286988 SGTC_38 0929-0051 58.268 µM 0.161423675831709 0.439135937256887 no 1458 0.435879860290927 2126 1379719 SGTC_2404 5161160 200 µM 0.161296818443802 0.439181782783263 no 1459 0.435929814483007 2018 2831543 SGTC_1842 st055362 61.2 µM 0.160901249585965 0.439324744316347 no 1460 0.43608558905119 2026 676032 SGTC_1351 1496-0003 46.5 µM 0.160776370154068 0.439369878318127 no 1461 0.436134768490295 2113 3891978 SGTC_42 0133-0086 60.653 µM 0.159654273193863 0.439775462587681 no 1462 0.436576711722841 2058 162923 Model of phenazepam hydroxylation. SGTC_2083 5306046 65.942 µM 0.158855621529735 0.440064175419205 no 1463 0.436891312750656 2008 539837 SGTC_3026 9090633 49.47 µM 0.158694138334863 0.440122555524442 no 1464 0.436954928292888 2038 25236842 SGTC_403 arphamenine a 50 µM 0.157881674811211 0.440416300588839 no 1465 0.437275019164262 2040 5487158 An arginine aminopeptidase inhibitor. SGTC_3349 9149703 23.001 µM 0.157607953736546 0.440515271458538 no 1466 0.437382867868984 2112 4910494 SGTC_157 1348-1695 65.819 µM 0.155816207469877 0.441163214743434 no 1467 0.438088947476361 2117 5380510 SGTC_1928 4'-methoxychalcone 40.3 µM 0.155764053907614 0.441182077231522 no 1468 0.438109502773404 2167 641818 SGTC_956 1185-0240 191 µM 0.155433953356207 0.441301468482308 no 1469 0.438239609260503 2038 1416193 SGTC_2855 9016525 58.44 µM 0.154923341077656 0.441486157982542 no 1470 0.438440876143156 2097 43811474 SGTC_2194 5927483 104.545 µM 0.153981406728175 0.441826890910168 no 1471 0.438812198006343 2120 760979 SGTC_1995 st072814 61.1 µM 0.153792626272384 0.441895185057137 no 1472 0.438886624024619 1972 5769371 SGTC_2897 9048598 12.99 µM 0.153357710988289 0.442052528721244 no 1473 0.439058096036251 2038 6467404 SGTC_1228 0124-0032 52.5 µM 0.153313379509985 0.442068567478639 no 1474 0.439075575043375 2102 X1228 SGTC_927 2425-1185 123 µM 0.151989813862556 0.442547466069882 no 1475 0.439597484836235 1976 730375 SGTC_392 N-ethylmaleimide 8.33 µM 0.150031300673968 0.443256258135605 no 1476 0.440369960189822 2013 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_901 1112-0062 60.1 µM 0.149352050287021 0.443502123510411 no 1477 0.440637922802842 2081 1908457 SGTC_2581 avocatin a 64 µM 0.149247174408222 0.443540086927216 no 1478 0.4406792985058 2034 6710728 A skin care supplement. SGTC_2921 7974240 10.71 µM 0.149158290519217 0.443572261901224 no 1479 0.440714365545129 2085 2979074 YDR527W RBA50 SGTC_2183 6420625 130.508 µM 0.14855303407582 0.443791367846894 no 1480 0.440953167529054 2117 2897619 SGTC_368 fentichlor 4.58 µM 0.145555446954159 0.444876761809067 no 1481 0.44213617073847 2024 7329 A pesticide. SGTC_1049 3226-0134 66 µM 0.145443316660958 0.444917371050813 no 1482 0.442180433244715 2132 5702385 SGTC_813 k007-0158 173 µM 0.145308186870492 0.444966310586219 no 1483 0.442233775571463 2120 6523916 SGTC_1600 coumarin 106 71.1 µM 0.144616835677453 0.44521670820342 no 1484 0.442506702013547 2099 100336 A hepatotoxic, DNA x-linker. SGTC_880 0833-0487 87.2 µM 0.143516601955255 0.445615242318256 no 1485 0.442941100254227 2095 76075 SGTC_2453 5731132 22.18 µM 0.141915879100494 0.446195165041558 no 1486 0.443573225779258 2143 1362040 SGTC_1271 0832-2808 169 µM 0.140586890342476 0.44667672926786 no 1487 0.444098152680689 2153 3663794 SGTC_96 0929-0093 37.281 µM 0.140522112863038 0.446700203654343 no 1488 0.444123741146254 2020 6991579 SGTC_106 0092-0003 11.579 µM 0.140356842221835 0.446760096100554 no 1489 0.444189027577399 2166 1072148 SGTC_1488 4013-0813 75.9 µM 0.138776952564533 0.447332693587324 no 1490 0.444813203460019 2045 2910057 SGTC_3110 9122132 49.47 µM 0.138616174156049 0.447390970485282 no 1491 0.444876730787638 2136 918317 SGTC_391 gliotoxin 8.33 µM 0.137520061418614 0.447788305592201 no 1492 0.445309868335456 2090 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.136731453957079 0.448074204084946 no 1493 0.445621533178001 2123 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.136398307643755 0.448194989686985 no 1494 0.445753205740244 2024 6708561 SGTC_2450 5739737 12.93 µM 0.136184607593317 0.448272471354457 no 1495 0.445837671579424 2065 2262825 SGTC_856 0433-0016 11.3 µM 0.136153888307632 0.448283609471436 no 1496 0.445849813707809 2070 3911780 SGTC_3037 9091026 49.47 µM 0.134314286473483 0.44895068142692 no 1497 0.446577028316684 2172 25236398 YIL048W NEO1 SGTC_2740 felodipine 17.08 µM 0.133868396477422 0.449112390779044 no 1498 0.446753320630405 2178 3333 L-type calcium channel blocker SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.132132661091652 0.449741964065566 no 1499 0.447439681287793 2047 688803 SGTC_3227 9130768 49.47 µM 0.131873677427479 0.449835911618284 no 1500 0.447542104568018 2125 17720899 SGTC_815 1582-0027 36.9 µM 0.131217020504878 0.450074129622185 no 1501 0.447801815978274 2102 3128206 SGTC_362 0310-0100 9.03 µM 0.129980283766617 0.450522834234039 no 1502 0.448291012809914 2075 790235 SGTC_1064 honokiol 6.76 µM 0.129669625204748 0.450635555272043 no 1503 0.448413907602031 2072 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_330 1488-0319 80.1 µM 0.129055610127806 0.450858359537534 no 1504 0.448656823088624 2072 6846614 SGTC_1183 1254-0324 198 µM 0.128599493186114 0.451023878205269 no 1505 0.448837283678799 2133 5799357 SGTC_3151 9099821 49.47 µM 0.128344453520397 0.451116432363983 no 1506 0.448938193577342 2085 17174189 SGTC_679 0422-0091 41.4 µM 0.125526678965111 0.45213918145 no 1507 0.450053302658669 2112 627384 YHR062C RPP1 SGTC_215 1287-0124 461.5 µM 0.125455666385628 0.452164960551047 no 1508 0.450081410384708 2194 5560863 SGTC_349 k015-0014 24 µM 0.125054628224057 0.452310549853117 no 1509 0.450240151333875 2060 2196908 SGTC_601 0986-0029 62.9 µM 0.121918895212893 0.453449137854853 no 1510 0.451481625522531 2099 24747981 SGTC_1554 st069299 38.7 µM 0.120121124565127 0.454102083524868 no 1511 0.45219359928478 2117 24207999 SGTC_1195 1502-0147 41.1 µM 0.119085661366847 0.454478217513234 no 1512 0.452603745236891 2171 817940 SGTC_2931 9014674 55.67 µM 0.117472342816719 0.455064339794957 no 1513 0.453242879755548 2149 2996810 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.117310467508084 0.455123154882885 no 1514 0.453307015217131 2143 364106 SGTC_1998 st075797 76.8 µM 0.11714178384245 0.455184444736981 no 1515 0.453373849465099 2213 24208315 SGTC_2474 5321570 43.32 µM 0.116813629106522 0.455303680177582 no 1516 0.45350387161548 2175 2841384 SGTC_1741 st038134 10.228 µM 0.116397501360701 0.455454886512155 no 1517 0.453668757780227 2147 1272587 SGTC_421 streptovitacin 30 mM 0.115927586013563 0.455625645145276 no 1518 0.453854966306633 2075 91467 include heat shock SGTC_1791 st048313 56.1 µM 0.115345796975471 0.455837067983411 no 1519 0.454085519920886 2217 1204976 SGTC_1048 3161-0300 24.5 µM 0.115233667986173 0.455877817232651 no 1520 0.454129956611966 2180 2165101 SGTC_1052 3253-3998 198 µM 0.115213193065479 0.455885258156468 no 1521 0.454138070880048 2192 5450317 SGTC_1201 1889-3372 45.9 µM 0.113789477814935 0.456402697555125 no 1522 0.454702339950502 2078 5392199 SGTC_440 fluspirilene 35.1 µM 0.112899340170214 0.456726249509081 no 1523 0.455055179727525 2151 3396 An atypical antipsychotic. SGTC_1251 0490-5699 265 µM 0.112345798827619 0.456927468135379 no 1524 0.455274614708633 2201 3883818 SGTC_298 1391-0729 10 µM 0.112324426889836 0.456935237301629 no 1525 0.455283087250965 2135 3237558 SGTC_1022 4477-0945 21.3 µM 0.111669993716614 0.457173146011037 no 1526 0.45554253601401 2121 4648966 SGTC_2455 5377712 9.75 µM 0.111381056687683 0.457278189334499 no 1527 0.45565709057943 2027 2243908 SGTC_1694 st024011 44.9 µM 0.111159564557855 0.457358715024057 no 1528 0.455744907832133 2208 2787533 SGTC_2298 7976326 193.81 µM 0.109913651095247 0.457811711910416 no 1529 0.456238928066619 2159 2235818 SGTC_905 2-aminofluorene 215 µM 0.108283738179957 0.458404408344327 no 1530 0.456885310907382 2227 1539 An established DNA mutagen. YPR165W RHO1 SGTC_585 0kpi-0023 191 µM 0.107893718501644 0.458546247643891 no 1531 0.457039999972245 2207 64601 SGTC_791 1348-1292 225 µM 0.107356239842237 0.458741722315092 no 1532 0.457253184675762 2186 5437054 SGTC_1636 st007707 68.9 µM 0.106135771329347 0.459185629344105 no 1533 0.457737315002965 2192 403051 SGTC_570 0987-0065 62.6 µM 0.102535754421467 0.460495316635452 no 1534 0.459165717234568 2228 3104428 SGTC_2688 kanamycin b 96.69 µM 0.102451232585161 0.460526070912208 no 1535 0.459199259923604 2139 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2772 vinpocetine 57.06 µM 0.100862546690411 0.461104176924506 no 1536 0.459829787425296 2190 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_645 0845-0943 5.41 µM 0.100808937056835 0.461123686344453 no 1537 0.459851066120054 2135 1885106 SGTC_153 4077-0274 519.67 µM 0.100327010168567 0.461299071594131 no 1538 0.460042357328217 2239 3121976 SGTC_1431 4049-0260 9.09 µM 0.099769992504639 0.461501793631166 no 1539 0.460263465833404 2194 3854841 SGTC_818 4072-2707 53.5 µM 0.0996092883908911 0.461560282444699 no 1540 0.46032725971748 2216 882871 SGTC_2237 6667747 47.222 µM 0.0990033053063983 0.46178083953512 no 1541 0.460567822872438 2072 729940 YDL015C TSC13 SGTC_1837 st055472 66.5 µM 0.0952956876037299 0.463130538865306 no 1542 0.462039983930562 2187 676091 SGTC_3303 9125618 40.5795 µM 0.0945812919516081 0.463390652516291 no 1543 0.462323705035499 2180 22695467 SGTC_3223 9129970 49.47 µM 0.0944287460557267 0.463446196977159 no 1544 0.462384290885889 2207 17248386 SGTC_2093 5331342 194.4 µM 0.0917419924712907 0.464424603815331 no 1545 0.463451516443836 2238 33839 SGTC_2817 7995342 71.43 µM 0.0915121784672507 0.464508302840428 no 1546 0.463542814911771 2167 18879975 SGTC_1136 pergolide 1.05886 µM 0.0912940273331086 0.46458775566257 no 1547 0.46362948183474 2101 47811 A dopamine receptor agonist. SGTC_2195 6536160 144.242 µM 0.0910954242964373 0.464660090100345 no 1548 0.463708384204947 2213 3834386 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0908402376036554 0.464753034934893 no 1549 0.463809768611399 2139 689007 SGTC_660 4031-1742 102 µM 0.0899908834107065 0.465062402998094 no 1550 0.464147229709202 2181 6738706 SGTC_1127 asiatic acid 681.4 nM 0.0898431787832338 0.465116204969397 no 1551 0.464205917601937 2141 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2942 9052777 62.25 µM 0.0873011816890033 0.466042236160314 no 1552 0.46521605737836 2200 6469503 SGTC_101 0490-5701 117.494 µM 0.0866387923060026 0.466283570234951 no 1553 0.465479315008293 2246 4661669 SGTC_395 anisomycin 6.25 µM 0.0858359184380516 0.466576104854387 no 1554 0.465798426525364 2132 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1070 indatraline 8.81 µM 0.085735351318729 0.466612748702782 no 1555 0.465838399645728 2153 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0850360275450885 0.466867570556004 no 1556 0.466116374294776 2239 616764 SGTC_786 4544-0069 423 µM 0.08491701552585 0.466910937894747 no 1557 0.466163682107306 2178 748821 YLR208W SEC13 SGTC_1697 st025554 27.742 µM 0.0846086271744311 0.467023314775309 no 1558 0.466286270085908 2248 1269519 SGTC_602 3130-1533 38.1 µM 0.0842004549657506 0.467172056987535 no 1559 0.466448528232117 2242 720941 SGTC_1524 corynanthine 62.1 µM 0.0837986739456228 0.467318474661224 no 1560 0.466608251175569 2155 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_48 0382-0018 55 µM 0.0837483762551285 0.467336804536855 no 1561 0.466628246763112 2255 762596 SGTC_1139 k015-0024 46.9 µM 0.0827334441418434 0.467706688739674 no 1562 0.467031745721145 2260 2766652 SGTC_2267 7931562 200 µM 0.0824962336981126 0.467793142293353 no 1563 0.467126056600635 2158 934880 SGTC_638 3970-0837 4.09 µM 0.0794242675271196 0.468912884715028 no 1564 0.468347583457487 2182 4118451 YLR208W SEC13 SGTC_654 1124-0271 80.9 µM 0.0751858310247535 0.470458211594847 no 1565 0.470033428824068 2193 5403748 SGTC_2050 5263056 171 µM 0.0742960469557577 0.470782682675836 no 1566 0.470387411206302 2266 763468 YGL055W OLE1 SGTC_1769 st044406 64.4 µM 0.0737472571973245 0.470982815528343 no 1567 0.470605747666049 2136 670903 SGTC_780 0109-0199 192 µM 0.0736083690008253 0.471033466491374 no 1568 0.470661005853782 2282 610414 SGTC_1372 2752-0194 270 µM 0.0734464839886805 0.471092504725726 no 1569 0.470725414288995 2276 823334 SGTC_1519 esterone 74 µM 0.0718893172064686 0.471660423880518 no 1570 0.47134499584355 2177 698 A steroid. SGTC_2575 plumbagin 510 nM 0.0713937221379725 0.471841186048653 no 1571 0.471542202934972 2246 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1936 st074407 74.3 µM 0.0697763765779175 0.472431132984708 no 1572 0.47218582504932 2283 809813 SGTC_2257 7960413 200 µM 0.0695231876384941 0.472523492312076 no 1573 0.4722865881198 2218 2974689 YIL048W NEO1 SGTC_1610 st001799 48.1 µM 0.0694632940687778 0.472545340756877 no 1574 0.472310424570723 2194 621897 SGTC_2378 9074213 121.43 µM 0.0691860797831947 0.472646466227073 no 1575 0.472420751639736 2269 657714 SGTC_2842 9000675 19.48 µM 0.0690594598195839 0.472692656725686 no 1576 0.472471145163758 2163 2989072 SGTC_3198 9112019 49.47 µM 0.0687162427266182 0.472817862908152 no 1577 0.472607744469531 2263 45595555 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.068595948631409 0.472861747036071 no 1578 0.472655621898141 2235 5377381 SGTC_556 4058-0063 51.5 µM 0.0679050825705806 0.473113786172732 no 1579 0.472930596394188 2211 6615692 SGTC_1917 st066507 28.5 µM 0.0678199583633375 0.473144841610132 no 1580 0.472964477931949 2178 3156428 SGTC_1292 0kpi-0043 232 µM 0.0652095524796503 0.474097261239686 no 1581 0.474003577769995 2203 3333905 SGTC_640 3381-0960 37.1 µM 0.0632049127880341 0.474828764849224 no 1582 0.474801666382357 2274 1745025 SGTC_1161 k007-0610 110 µM 0.0612921248864564 0.4755268304107 no 1583 0.475563281221178 2299 5843850 SGTC_3017 9080681 49.47 µM 0.0599932514269716 0.476000892904153 no 1584 0.476080504795786 2218 16451914 SGTC_1412 3909-8563 178 µM 0.0585972165882468 0.476510455192999 no 1585 0.476636463858098 2302 23767530 SGTC_2425 5628681 7.85 µM 0.0576998149012941 0.476838033297815 no 1586 0.476993870569793 2261 5714958 SGTC_292 k038-0015 474 µM 0.0574428784327475 0.476931825584931 no 1587 0.477096203660125 2277 46368540 SGTC_1036 k216-0215 33.5 µM 0.0573921791394451 0.476950333045276 no 1588 0.477116396438859 2321 622330 SGTC_1497 4476-2978 41.3 µM 0.057044172129942 0.477077372170179 no 1589 0.4772550040672 2261 1528379 SGTC_1156 4092-0367 4.88 µM 0.0569541566849509 0.477110232472411 no 1590 0.477290856745785 2226 1357585 SGTC_609 0986-0026 86.3 µM 0.0568097968693024 0.477162931611039 no 1591 0.477348354885186 2289 2848610 SGTC_286 k060-0067 22.9 µM 0.0564663778353038 0.477288299731436 no 1592 0.477485139686898 2282 5985051 SGTC_1522 st012842 45.6 µM 0.0540240542362231 0.478179955419518 no 1593 0.478457999857123 2306 3491067 YOR116C RPO31 SGTC_2406 ethylparaben 405.7 µM 0.0536460047494628 0.478317985487678 no 1594 0.478608601384922 2150 8434 A possible steroid mimic. SGTC_3089 9117425 49.47 µM 0.0533917162905777 0.478410830493439 no 1595 0.478709902621415 2164 9401657 SGTC_1908 st060353 56.5 µM 0.053375133872677 0.478416885054679 no 1596 0.47871650862945 2310 4227716 SGTC_1159 4092-0538 61.2 µM 0.0533004431597961 0.478444156139115 no 1597 0.478746263557457 2329 717301 SGTC_2331 7980721 200 µM 0.0522299918626194 0.478835010505361 no 1598 0.479172717745185 2265 2981221 SGTC_2982 9019404 25.97 µM 0.0521141906329079 0.478877294287514 no 1599 0.479218852920776 2265 22333232 SGTC_2592 piperlongumine 83.33 µM 0.0518220629029831 0.478983963167646 no 1600 0.479335237757489 2249 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_92 0063-0024 660.874 µM 0.0517084348876542 0.479025454237523 no 1601 0.479380508082257 2324 3594437 SGTC_99 0109-0120 622.8 µM 0.0501461153414641 0.479595955324614 no 1602 0.480002975605938 2307 759414 SGTC_911 3456-4043 236 µM 0.0499082496773441 0.479682818728501 no 1603 0.480097751603109 2281 914281 SGTC_2181 6316240 54.2555 µM 0.049763600374992 0.479735642002103 no 1604 0.480155386709305 2252 12779990 SGTC_1502 4534-4282 27.7 µM 0.0490788802440263 0.479985694056059 no 1605 0.480428217122385 2272 3278949 SGTC_1682 st012968 530 nM 0.0487947314488804 0.480089464303052 no 1606 0.480541440434897 2221 24207270 SGTC_2148 5546263 113.568 µM 0.0481137173291416 0.480338173998566 no 1607 0.48081280700969 2277 792097 SGTC_1933 st074711 15.9 µM 0.0481066264298774 0.480340763670175 no 1608 0.480815632597283 2318 17250958 SGTC_529 4076-0302 30.3 µM 0.0460925195114509 0.481076370048529 no 1609 0.481618254119205 2192 5816522 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0455619066812173 0.481270175047399 no 1610 0.481829715843685 2289 6708760 SGTC_1341 1486-1360 280 µM 0.0445392788715549 0.481643699724676 no 1611 0.482237271507914 2326 3976547 SGTC_2180 6301957 200 µM 0.0430232561711313 0.482197471204565 no 1612 0.48284149763563 2330 845462 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0426222737967844 0.482343947492512 no 1613 0.483001319850056 2294 368090 SGTC_1250 0485-0349 40.2 µM 0.0422129522348183 0.482493472490222 no 1614 0.483164468687136 2298 6842794 YDL195W SEC31 SGTC_994 3910-0338 138 µM 0.0417992816571408 0.482644588683366 no 1615 0.483329353834301 2304 3479481 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0398491265266222 0.483357024564848 no 1616 0.484106705003348 2282 5282362 SGTC_1298 1079-1278 263 µM 0.0398252613357114 0.483365743393919 no 1617 0.484116218285237 2326 2840950 SGTC_1323 1348-1351 11.2 µM 0.0392863327688702 0.483562635865006 no 1618 0.484331051537694 2213 6989654 SGTC_2718 lomofungin 53.02 µM 0.036037691648079 0.484749579475266 no 1619 0.485626152436598 2315 5351222 A RNA synthesis inhibitor. SGTC_398 bronopol 33.3 µM 0.0359909423658298 0.484766661093714 no 1620 0.485644790610798 2279 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2699 st077704 54.6 µM 0.0357704839716777 0.484847214282546 no 1621 0.485732684188683 2313 645852 SGTC_115 0527-0192 112.043 µM 0.0353574940576055 0.484998118134491 no 1622 0.485897339165098 2235 4233931 SGTC_2752 diclazuril 33.15 µM 0.0348050278630306 0.485199989075765 no 1623 0.486117605703647 2339 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2825 7998094 58.44 µM 0.0344633722474898 0.485324831811634 no 1624 0.486253824849529 2317 2987815 SGTC_3317 9138495 8.753 µM 0.0339315187679118 0.485519176692511 no 1625 0.486465879655387 2333 17020139 SGTC_2491 paeonol 100 µM 0.0333995770904758 0.485713557242276 no 1626 0.486677973454383 2307 11092 Increases levels of cortical cytochrome oxidase. SGTC_1240 0356-0016 42.1 µM 0.0323971385281075 0.486079874557193 no 1627 0.487077672207785 2314 4305613 SGTC_530 4358-1714 28 µM 0.0318544236835416 0.486278201701609 no 1628 0.48729407240439 2278 1564641 SGTC_2507 purpurin 79.67 µM 0.0315220000358838 0.486399682705453 no 1629 0.487426623684921 2358 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1705 st027868 56.3335 µM 0.0308865825880783 0.486631893362606 no 1630 0.487679995181362 2344 292948 SGTC_184 1494-0393 24.714 µM 0.0301647793767927 0.486895678831355 no 1631 0.487967818863455 2328 3090647 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.02974636811663 0.487048591299445 no 1632 0.488134665928746 2348 5106787 A p450 inhibitor. SGTC_2626 ethyl orsellinate 100 µM 0.0294294638848741 0.487164408304323 no 1633 0.488261037097505 2337 75653 A natural product. SGTC_2381 9035592 200 µM 0.0286491676276159 0.487449582884634 no 1634 0.488572199031603 2225 4749657 SGTC_521 r062-0005 13.8 µM 0.0274641333115968 0.487882689156847 no 1635 0.489044773260281 2349 2832033 SGTC_1442 4112-3290 3 µM 0.0234830478532291 0.489337797744019 no 1636 0.490632480305213 2366 704353 SGTC_1275 0867-0008 21.1 µM 0.0212168203728459 0.490166180960608 no 1637 0.491536348292712 2337 3422836 SGTC_2933 9026794 32.47 µM 0.0209630944008527 0.490258929138682 no 1638 0.491637547801724 2359 17586027 SGTC_229 benomyl 22.8748 µM 0.0197003424707631 0.49072052911794 no 1639 0.4921412087907 2341 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2750 bromebric acid 70.15 µM 0.0193850010761491 0.490835804380711 no 1640 0.492266987784451 2350 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3143 9086658 49.47 µM 0.0189970228706266 0.490977633589324 no 1641 0.492421740193649 2339 25236626 SGTC_3114 9122766 49.47 µM 0.0187686615090994 0.491061113841776 no 1642 0.4925128269553 2286 17176985 SGTC_2607 solasodine 47.35 µM 0.0179531961331981 0.491359220224036 no 1643 0.492838095730411 2343 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2003 4023581 200 µM 0.0134743006071565 0.492996633570251 no 1644 0.494624694443317 2366 16641307 SGTC_29 0299-0004 12.984 µM 0.0132447149036651 0.493080569886007 no 1645 0.494716277714122 2379 16871 A napthoquinone isolated from Swertia calycina. SGTC_3234 9132280 49.47 µM 0.0119334661323337 0.493559966954734 no 1646 0.495239348800505 2361 17612295 SGTC_2681 menadione 3.18 µM 0.0114089245553809 0.49375174380598 no 1647 0.495448596358979 2369 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_420 mitomycin C 81.9 mM 0.0107613318958536 0.493988511164343 no 1648 0.495706932574155 2386 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1338 1486-1223 76 µM 0.0100889001334714 0.494234362225717 no 1649 0.495975179452461 2355 3444526 SGTC_2087 5276107 200 µM 0.00981407314596608 0.494334843698836 no 1650 0.496084814128417 2385 144405 SGTC_3159 9100096 49.47 µM 0.00943700698507125 0.494472706155657 no 1651 0.49623523479314 2389 25236875 SGTC_2250 alverine citrate 130 µM 0.0065659862576735 0.495522425611893 no 1652 0.497380569290852 2379 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1674 st016616 23.6 µM 0.00410389804519285 0.496422653730229 no 1653 0.498362786150971 2395 625830 SGTC_1162 k048-0130 20.1 µM 0.00375560831328694 0.496550002575958 no 1654 0.498501732577279 2395 6797406 SGTC_561 1550-0330 72.9 µM 0.00345061587456783 0.496661520465187 no 1655 0.498623406166004 2394 6812934 SGTC_2096 5468907 200 µM 0.00284611453115263 0.496882551998625 no 1656 0.498864566111564 2399 759785 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0025105156368456 0.497005261718618 no 1657 0.49899845021893 2401 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1993 st073995 70.8 µM 0.00155338564564353 0.497355232068118 no 1658 0.499380289037412 2393 3098394 SGTC_3329 9141233 27.5565 µM 0.00108776321758624 0.497525485602868 no 1659 0.499566045347017 2400 4909101 YNL103W MET4 SGTC_1 0258-0098 57.368 µM 0.000604686828641119 0.497702121605393 no 1660 0.499758764872354 2337 6790032 YDR047W HEM12 SGTC_2088 5278280 127.392 µM 0.000487353410652824 0.497745024425474 no 1661 0.499805574126689 2404 791502 SGTC_1284 0929-0043 16 µM -2.24887874595461e-05 0.497931447895048 no 1662 0.499991028271848 2407 1239883 SGTC_1860 st056228 74.6 µM -6.04710875621619e-05 0.497945336117065 no 1663 0.499975875526444 2408 688679 SGTC_2196 6573537 42.6665 µM -0.000238735666050502 0.498010518564952 no 1664 0.499904758249877 2408 2903087 SGTC_604 1000-0114 314 µM -0.000793025960247367 0.498213195157332 no 1665 0.499683628448162 2409 1572745 SGTC_2347 9049783 174.81 µM -0.00199277884235614 0.498651887058135 no 1666 0.499204996790477 2409 6467988 YPL169C MEX67 SGTC_386 1509-0011 3.07 µM -0.00204932420454013 0.498672563020691 no 1667 0.499182438500815 2409 3107280 SGTC_3009 9080819 71.4286 µM -0.00290059446700103 0.498983832662963 no 1668 0.498842831851444 2414 17027216 SGTC_334 1502-1024 68.5 µM -0.00300483812401292 0.499021949729531 no 1669 0.498801244830507 2421 3296216 SGTC_1221 2958-7315 257 µM -0.00352489629639838 0.49921211098949 no 1670 0.498593772745374 2421 4562705 SGTC_1942 st076330 65.2 µM -0.0037305013618635 0.499287291319897 no 1671 0.498511748731568 2425 24208414 SGTC_1002 4049-0206 172 µM -0.00379912007756814 0.499312382038807 no 1672 0.498484374018654 2419 4662749 SGTC_797 k781-0471 270 µM -0.00382079817064344 0.499320308724309 no 1673 0.498475725773537 2429 23738129 SGTC_1409 3909-8004 61.9 µM -0.00439971345249437 0.499531991610474 no 1674 0.498244773944943 2418 2119279 SGTC_2967 9089538 49.85 µM -0.00477420094580854 0.499668924662163 no 1675 0.498095376622932 2416 728216 SGTC_1321 1326-2144 215 µM -0.00523388502625551 0.499837010284288 no 1676 0.497911991505266 2402 3513030 SGTC_3277 9138724 49.47 µM -0.00542132315068866 0.499905547916304 no 1677 0.497837215573784 2426 15943418 SGTC_1802 st050112 57.9 µM -0.00567333482874256 0.499997697176022 no 1678 0.49773667900743 2408 4662563 SGTC_1677 st019204 53.9 µM -0.00568593044874455 0.499997697176022 no 1679 0.49773165416311 2435 3945625 SGTC_2027 5150920 200 µM -0.00585208778943069 0.499936940959725 no 1680 0.497665368077846 2421 786715 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.00606564423825905 0.499858853038038 no 1681 0.49758017289389 2420 3256 An antibiotic and ribosome inhibitor. SGTC_2380 9035439 200 µM -0.00622408156922682 0.499800919684819 no 1682 0.497516966737162 2455 6462575 SGTC_632 0781-2353 4.65 µM -0.00718803068998333 0.499448447302502 no 1683 0.497132415338589 2438 6811515 YHR007C ERG11 SGTC_3087 9117406 49.47 µM -0.00827515726979256 0.499050935052425 no 1684 0.496698727565699 2444 42546093 SGTC_2108 5365811 200 µM -0.00869370241648982 0.498897892548957 no 1685 0.496531758221442 2432 780283 SGTC_3333 9141820 12.094 µM -0.0106650502605556 0.49817706483889 no 1686 0.495745341185098 2436 1939433 SGTC_2489 cantharidin 73.42 µM -0.0110888698144755 0.49802209497616 no 1687 0.495576271648501 2420 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_559 1550-0661 158 µM -0.0118960043169956 0.497726966627772 no 1688 0.49525429284177 2446 5830875 SGTC_2280 7785178 200 µM -0.0127191837895033 0.497425972726139 no 1689 0.494925916626742 2429 2954328 SGTC_681 1642-0006 26.6 µM -0.0132106642384446 0.497246264586158 no 1690 0.494729860775775 2427 4446530 SGTC_1446 4239-0190 62 µM -0.0133747094179284 0.497186282151667 no 1691 0.494664421999481 2443 1340085 SGTC_3249 9135183 49.47 µM -0.0137069878084186 0.497064786142787 no 1692 0.494531874253436 2491 4902779 SGTC_3338 9144300 39.5675 µM -0.0142803541024402 0.496855138138312 no 1693 0.494303156594892 2432 4901274 SGTC_2185 6113692 200 µM -0.0152882648487452 0.496486603657968 no 1694 0.493901102342404 2453 874150 SGTC_2159 5658611 73.75 µM -0.0159389292478597 0.496248695011988 no 1695 0.493641556446373 2425 793844 SGTC_1806 st050005 60.3 µM -0.0166556357466179 0.495986640309075 no 1696 0.493355669895955 2440 5194765 SGTC_1131 3454-3128 32.3 µM -0.0168511749605208 0.49591514415466 no 1697 0.493277671983039 2506 710982 SGTC_767 0929-0023 86 µM -0.0170166851727647 0.495854627783416 no 1698 0.493211652428108 2434 1204563 SGTC_134 0269-0018 6.916 µM -0.0173292454689883 0.495740344976221 no 1699 0.49308697729665 2450 4378915 SGTC_2883 9059145 45.46 µM -0.0176327106850979 0.495629387977885 no 1700 0.49296593068818 2433 16476510 SGTC_2515 chrysin 20.77 µM -0.0181420553407035 0.495443155358313 no 1701 0.492762764076997 2450 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_875 0709-0210 25.7 µM -0.0188416588688618 0.49518735966566 no 1702 0.492483710370903 2443 6251364 SGTC_2625 euphol 100 µM -0.0211338492931913 0.494349281633679 no 1703 0.491569441544175 2452 6708538 A triterpene alcohol. SGTC_2222 6885208 172.143 µM -0.0217151584371034 0.494136745333862 no 1704 0.491337585969995 2440 609514 SGTC_2010 4012422 159 µM -0.0217984521033487 0.494106291917842 no 1705 0.491304364468621 2474 952393 SGTC_2116 5511452 16.8835 µM -0.0223388443126008 0.493908717247943 no 1706 0.491088831662322 2473 870744 SGTC_528 3492-0019 172 µM -0.0227660346423422 0.493752531764932 no 1707 0.490918450713757 2443 2869262 SGTC_765 1319-0117 244 µM -0.0241046089470994 0.493263140589096 no 1708 0.490384583491866 2444 3487746 YGL099W LSG1 SGTC_305 1682-2595 20.8 µM -0.0245421849298723 0.493103162223832 no 1709 0.4902100675647 2481 226033 SGTC_1198 1612-1005 86.7 µM -0.0247562995449579 0.493024882036428 no 1710 0.490124674137884 2469 6998509 SGTC_1031 k035-0009 16 µM -0.0253672658462338 0.492801514574327 no 1711 0.489881010385952 2452 5180959 SGTC_1428 4049-0204 61.7 µM -0.0260238434837645 0.492561474261472 no 1712 0.489619160269727 2454 X1428 SGTC_3298 9116858 71.43 µM -0.0265721607848146 0.4923610152507 no 1713 0.48940048894597 2482 2506942 SGTC_206 4546-0025 72.014 µM -0.0270308010014661 0.49219334271387 no 1714 0.489217583677656 2464 6620745 YIL048W NEO1 SGTC_699 0375-0592 111 µM -0.0276204804033703 0.491977766089385 no 1715 0.488982423448122 2448 762578 SGTC_527 4476-4215 268 µM -0.0287046162988794 0.491581430854078 no 1716 0.488550087306061 2488 4418754 SGTC_156 3474-0145 5.642 µM -0.0304014556584594 0.490961122107359 no 1717 0.487873441973049 2440 2265471 SGTC_610 4215-0184 155 µM -0.0309776283858593 0.490750497175783 no 1718 0.487643690535396 2485 5605015 SGTC_883 0850-0245 24.6 µM -0.0310864961495988 0.490710699909602 no 1719 0.4876002794887 2594 6823229 YPR165W RHO1 SGTC_2339 9000433 200 µM -0.0324446879396357 0.49021421262805 no 1720 0.487058712704054 2493 2988954 SGTC_492 tmb-8 126 µM -0.0328314008986899 0.490072852367763 no 1721 0.486904518704102 2455 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_435 c-PAF 6.7 µM -0.033655166161548 0.489771734825585 no 1722 0.486576065460506 2462 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2890 9046729 58.44 µM -0.0347334241136341 0.489377599359711 no 1723 0.486146154205365 2500 903329 SGTC_1274 0865-0114 173 µM -0.0353678338180267 0.489145708498711 no 1724 0.485893216775864 2494 870624 SGTC_485 niflumic acid 177 µM -0.0354793824618579 0.48910493536477 no 1725 0.485848743217719 2529 4488 A COX2 inhibitor. SGTC_719 2810-4230 27.3 µM -0.0357429082923525 0.489008612154698 no 1726 0.485743678262641 2460 721079 SGTC_2835 9006588 71.43 µM -0.0364440153036449 0.488752348656023 no 1727 0.485464159167853 2599 2345538 SGTC_3103 9120822 49.47 µM -0.0370215700170296 0.488541248571598 no 1728 0.485233903570764 2466 17141819 SGTC_2894 9048625 32.47 µM -0.0378902198469544 0.488223757351874 no 1729 0.484887605441296 2478 4092861 SGTC_519 k048-0011 62.8 µM -0.0381284203427788 0.488136696446309 no 1730 0.484792645811792 2564 6836379 SGTC_1919 st067113 52.3 µM -0.0388009757785631 0.487890884383689 no 1731 0.484524533431531 2517 1268243 SGTC_2778 tioconazole 65.09 nM -0.0393677738874091 0.487683729099396 no 1732 0.484298586347474 2480 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1831 st055328 12 µM -0.0396139858003639 0.487593743771077 no 1733 0.484200438567735 2475 1103068 SGTC_2260 7964312 200 µM -0.0398957756402027 0.487490756226538 no 1734 0.484088109487167 2591 231951 SGTC_628 1636-0253 16 µM -0.0402666214547355 0.487355222094734 no 1735 0.483940282203238 2500 4456143 SGTC_1865 st057639 52.2 µM -0.0411173002901627 0.487044327492802 no 1736 0.483601191314602 2474 688818 SGTC_689 0833-0039 98 µM -0.041929076565978 0.486747657811332 no 1737 0.483277618513198 2509 5374726 SGTC_1454 4239-0054 42.6 µM -0.0420893281137965 0.486689093552131 no 1738 0.483213743782419 2606 1340767 SGTC_3111 9122088 49.47 µM -0.042231672075319 0.486637073898031 no 1739 0.483157007205123 2505 16876704 SGTC_1832 st054113 55 µM -0.0430395787000638 0.486341828452822 no 1740 0.482834991914836 2479 1251267 SGTC_1672 st016598 6.51 µM -0.0436718192444177 0.486110784513693 no 1741 0.482583001381232 2543 4665860 YNL267W PIK1 SGTC_2084 5306078 60.6385 µM -0.0440628839722241 0.485967877413505 no 1742 0.482427139166399 2524 679340 SGTC_1604 st002052 72.4 µM -0.0442082939085161 0.485914740601346 no 1743 0.48236918546783 2589 6254834 YHR062C RPP1 SGTC_2914 7968218 45.32 µM -0.0454528085048156 0.485459970876689 no 1744 0.481873194675047 2529 2977111 SGTC_3335 9143315 29.6265 µM -0.0465881785553705 0.485045101162014 no 1745 0.4814207269735 2514 4899691 SGTC_1226 3909-7979 35.4 µM -0.047153329602555 0.484838598238732 no 1746 0.48119551184878 2553 6615510 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0473965410723345 0.48474973142285 no 1747 0.481098592874234 2491 688667 SGTC_822 1487-0950 154 µM -0.0478878615978046 0.484570210581883 no 1748 0.480902806667238 2490 1958375 SGTC_3273 9137859 49.47 µM -0.0484025987175809 0.484382137038587 no 1749 0.480697694128596 2482 2377234 SGTC_738 1315-0003 72.4 µM -0.0487871144603904 0.484241645767214 no 1750 0.480544475558866 2520 6251474 SGTC_617 3770-0098 35 µM -0.0489944690599114 0.484165885021172 no 1751 0.480461851849382 2503 5962639 SGTC_23 0213-0011 39.996 µM -0.049040254047881 0.484149156726269 no 1752 0.480443608212054 2524 627608 SGTC_258 haloperidol 50.781 µM -0.0490569485947319 0.484143057107209 no 1753 0.480436956058039 2496 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_705 1124-0212 310 µM -0.0493185880620204 0.484047463438977 no 1754 0.480332703205507 2499 9554485 SGTC_2549 cedrol 20.94 µM -0.0501048329053658 0.483760203340002 no 1755 0.480019424238036 2510 6708665 A sedative which affects the nervous system. SGTC_1432 4049-0298 68.4 µM -0.0501487343002917 0.483744163902809 no 1756 0.480001932105435 2520 741646 SGTC_1661 st013063 9.66 µM -0.0503184745615922 0.483682149304181 no 1757 0.479934300923222 2497 721395 SGTC_1784 st039334 36.3 µM -0.0509743831281715 0.483442516855194 no 1758 0.479672966652779 2595 3496984 SGTC_6 0844-0013 19.835 µM -0.0513653335859293 0.483299688177353 no 1759 0.47951720404103 2514 1584900 SGTC_2857 9024691 58.44 µM -0.0523175396485673 0.482951821048686 no 1760 0.479137838918405 2560 16478292 SGTC_1377 2944-0135 198 µM -0.053267811290354 0.482604673555286 no 1761 0.478759263322306 2541 1894137 SGTC_3049 9092223 49.47 µM -0.0543677650129805 0.482202861593331 no 1762 0.478321080324237 2574 8623917 SGTC_1720 st037298 9.481 µM -0.0559235162728407 0.481634578222152 no 1763 0.477701368432884 2545 597396 SGTC_2112 5488546 200 µM -0.0561878511484059 0.481538025902089 no 1764 0.477596079626492 2507 600757 SGTC_1972 st070201 17.4 µM -0.0565379827513586 0.481410136694998 no 1765 0.477456619020822 2532 2829099 SGTC_753 1322-0200 289 µM -0.0565928257326077 0.48139010489905 no 1766 0.477434774811647 2576 5403907 SGTC_3354 9151612 71.43 µM -0.0571498621996231 0.481186645967814 no 1767 0.47721290850299 2538 27261949 SGTC_2401 5128683 200 µM -0.0574150104456456 0.48108980164101 no 1768 0.477107303059975 2530 708373 SGTC_1077 5-fluorocytosine 377 nM -0.0588222241776565 0.480575841320583 no 1769 0.476546853386703 2575 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1929 genistein trimethyl ether 50.5 µM -0.0591670111004224 0.480449918790621 no 1770 0.476409542460251 2509 136420 SGTC_557 1315-0110 16.2 µM -0.0615342608851163 0.479585408940958 no 1771 0.475466864926384 2519 6833801 SGTC_3131 9127911 49.47 µM -0.0622428907122938 0.479326638743039 no 1772 0.475184703417734 2647 45595681 SGTC_2262 9014885 67.46 µM -0.0624764898485588 0.479241337302164 no 1773 0.475091691870198 2575 6457424 SGTC_1727 st034309 9.9045 µM -0.0625123494615248 0.479228242831598 no 1774 0.475077413863422 2730 870305 SGTC_1771 st048882 4.1505 µM -0.0634376041815888 0.47889038527349 no 1775 0.474709021866575 2513 4580403 SGTC_3300 9124615 50.48 µM -0.0642858166172259 0.478580673091839 no 1776 0.474371323396804 2624 24824903 SGTC_694 1315-0438 43.2 µM -0.0644984076960092 0.478503050634435 no 1777 0.47428668747404 2561 6793154 SGTC_1345 1488-0192 31.4 µM -0.0649534275222275 0.478336913965322 no 1778 0.474105540678417 2527 658348 SGTC_2594 a-mangostin 100 µM -0.0660645372203336 0.477931241883927 no 1779 0.473663222172087 2603 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_60 0986-0278 202 µM -0.0670484930393484 0.477572013438851 no 1780 0.473271549081823 2515 3110598 SGTC_1071 trifluoperazine 6.31 µM -0.0692055328598851 0.476784572671667 no 1781 0.472413009541977 2639 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_525 k781-2675 26.7 µM -0.0705837263062141 0.476281501869118 no 1782 0.471864531315692 2532 3651118 YDL195W SEC31 SGTC_1263 0774-1208 64.8 µM -0.071328825617639 0.476009539988295 no 1783 0.471568027063195 2543 906585 SGTC_2793 7325131 81.82 µM -0.072114576847553 0.475722752231887 no 1784 0.471255362891411 2597 4176441 SGTC_1620 st003704 16.5 µM -0.07215025333326 0.475709731131498 no 1785 0.471241167012113 2541 2834414 SGTC_375 3970-0961 9.27 µM -0.0727041618946991 0.47550757052609 no 1786 0.471020768301853 2575 2898222 SGTC_1898 st060199 18.6 µM -0.0730124213066912 0.475395067483295 no 1787 0.470898116559961 2547 688866 SGTC_2383 9036125 200 µM -0.0738711425179189 0.475081677045897 no 1788 0.470556459014102 2544 79580 SGTC_2536 dehydroabietamide 32.04 µM -0.0743710611237673 0.474899238761664 no 1789 0.470357567447566 2589 3983547 SGTC_3041 9091929 49.47 µM -0.0745820351845711 0.47482224831392 no 1790 0.470273634076862 2607 25236887 SGTC_1369 1866-0067 208 µM -0.0762040646093328 0.474230355162714 no 1791 0.469628374502083 2523 3531355 SGTC_969 1313-0238 134 µM -0.0785969358370585 0.47335727911519 no 1792 0.468676612424239 2564 5212874 SGTC_271 rotenone 740 µM -0.0795702713578215 0.473002178984026 no 1793 0.468289520121354 2680 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2776 terbinafine 19.92 µM -0.0795931961302833 0.472993815640759 no 1794 0.468280403375434 2525 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0800220587084132 0.472837361544635 no 1795 0.468109855957792 2541 442882 SGTC_1113 artemisinin 1.17947 µM -0.0801135801222183 0.472803974001691 no 1796 0.468073461044718 2542 2240 An anti-malaria and mitochondrial poison. SGTC_352 k048-0007 5.11 µM -0.0808049334646563 0.47255177047956 no 1797 0.467798542282617 2538 6811911 SGTC_605 1315-0399 119 µM -0.0810401186158764 0.472465978180362 no 1798 0.467705023685295 2637 24020461 SGTC_1309 pyrazolanthrone 13.4 µM -0.0823966200628894 0.471971170217635 no 1799 0.467165661855766 2579 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3286 9117135 37.221 µM -0.0833410928197652 0.471626682525799 no 1800 0.466790163291091 2589 3438150 SGTC_991 3996-0057 64.7 µM -0.0841339239713621 0.471337521082579 no 1801 0.46647497641164 2619 715343 SGTC_2937 9044753 11.33 µM -0.0844070469116571 0.471237911152587 no 1802 0.466366402328824 2561 6465530 YGL099W LSG1 SGTC_1092 toremifene 6.32 µM -0.0848544465093239 0.471074745144151 no 1803 0.466188553764376 2543 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1989 st071868 50.2 µM -0.0852316190376748 0.470937194620742 no 1804 0.466038626837709 2553 16414057 SGTC_1664 st014217 9.02 µM -0.0870662717779817 0.470268167421418 no 1805 0.465309417383842 2572 3982782 SGTC_2130 NSC 7 2.4545 µM -0.087438400403104 0.470132476618766 no 1806 0.465161523570777 2612 21448 SGTC_3156 9099931 49.47 µM -0.0895386791765908 0.469366708745961 no 1807 0.46432690773858 2584 18111053 SGTC_2002 4023503 131 µM -0.0919780654611889 0.468477443670359 no 1808 0.463357733465823 2562 4736863 YCR052W RSC6 SGTC_2278 7948257 134.34 µM -0.0920167220989809 0.468463352856206 no 1809 0.463342376821921 2565 1247028 SGTC_852 0418-0143 439 µM -0.0923090856468299 0.468356784071367 no 1810 0.463226234945358 2582 5369229 SGTC_2322 7413319 38.22 µM -0.09291338150629 0.468136520730646 no 1811 0.462986187415942 2669 1840400 SGTC_2508 celastrol 40.54 µM -0.0932638373463222 0.468008785491253 no 1812 0.4628469802224 2550 122724 Celastrol is a natural product and antioxidant. SGTC_907 3448-6986 75.5 µM -0.0938877549508906 0.467781386213656 no 1813 0.462599160501097 2628 590582 SGTC_1360 1598-0022 39.8 µM -0.0950605124688636 0.467353979739737 no 1814 0.462133381238369 2662 761525 SGTC_2755 lomerizine 42.69 µM -0.096486195489478 0.466834446378762 no 1815 0.461567218587585 2606 3949 A calcium channel blocker. SGTC_2021 4019055 173 µM -0.0967606059366599 0.466734454883897 no 1816 0.461458254496229 2680 44827708 YER133W GLC7 SGTC_1477 0139-0234 16 µM -0.0971341645793155 0.466598338488947 no 1817 0.461309924860729 2561 620880 SGTC_466 geldanamycin 89.2 µM -0.0978616858812145 0.466333257263092 no 1818 0.461021062070286 2577 5288382 HSP90 inhibitor. SGTC_2788 5282734 71.43 µM -0.0978947205388808 0.466321221037766 no 1819 0.461007946125647 2665 743706 SGTC_2634 4'-methoxyflavone 100 µM -0.0982446671371882 0.466193719381845 no 1820 0.460869007374624 2628 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1266 0828-0227 32.9 µM -0.0996196318702951 0.465692790152147 no 1821 0.460323153688985 2666 3913820 SGTC_575 k072-0246 11.9 µM -0.100070484566386 0.465528546611004 no 1822 0.460144183793414 2581 6796779 SGTC_630 4356-0227 183 µM -0.101282649162528 0.465086989877387 no 1823 0.459663044661681 2592 779312 SGTC_149 3970-0822 46.1 µM -0.101424731492219 0.465035236171196 no 1824 0.459606652404963 2572 3114250 YBL034C STU1 SGTC_1718 roemerine 11.9335 µM -0.102724409751309 0.464561853934259 no 1825 0.459090849973205 2616 235224 An aporphine alkaloid with mutagenic activity. SGTC_191 3914-0123 66.505 µM -0.103305183642327 0.46435033464434 no 1826 0.45886038084078 2592 3144412 SGTC_1724 st037281 8.293 µM -0.103447965921099 0.464298334525283 no 1827 0.458803722508973 2601 574124 YDL195W SEC31 SGTC_812 4251-0442 148 µM -0.106143567482652 0.463316734262729 no 1828 0.457734222257804 2573 5723007 SGTC_65 0798-0905 34.986 µM -0.107395997216587 0.46286073900384 no 1829 0.457237414950277 2832 3602145 SGTC_2418 pentamidine 31.67 µM -0.107447783097839 0.46284188540667 no 1830 0.457216874229714 2575 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1849 st056239 19.2 µM -0.108057982396202 0.462619737490157 no 1831 0.456974849058984 2616 5393181 SGTC_467 ro 31-8220 72.8 µM -0.109887112121628 0.461953898365514 no 1832 0.456249451839427 2688 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_633 0437-0093 97.7 µM -0.11028596149546 0.461808723458086 no 1833 0.456091295224803 2589 2831118 SGTC_1893 st059353 36.1 µM -0.110344657505373 0.461787359461448 no 1834 0.45606802095423 2648 3112488 SGTC_1706 st031321 9.9705 µM -0.112583320212202 0.460972620625122 no 1835 0.455180454753573 2670 6103185 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.112622497671629 0.460958363830089 no 1836 0.455164923981887 2709 688798 SGTC_2400 5203494 178.7 µM -0.114541916605083 0.460259943330929 no 1837 0.454404110191851 2591 6777674 SGTC_287 k060-0039 29.6 µM -0.114621307456817 0.460231057943724 no 1838 0.454372645055897 2698 5861974 SGTC_1032 k061-1018 98.7 µM -0.115915152354217 0.459760338044744 no 1839 0.453859893403005 2828 4005393 SGTC_3032 9089427 49.47 µM -0.116592546569715 0.459513914467645 no 1840 0.453591472207921 2707 17173707 SGTC_1883 5-benzylidenerhodanine 20 µM -0.117554376031836 0.459164045313385 no 1841 0.453210378425945 2693 1273210 SGTC_1534 6-azauridine 81.6 µM -0.118128355255159 0.458955273220829 no 1842 0.452982978249124 2584 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2678 equilin 100 µM -0.118149002274783 0.45894776354025 no 1843 0.452974798560585 2677 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1635 st007035 42.4 µM -0.118196078455246 0.458930641168429 no 1844 0.452956148558788 2589 3716403 SGTC_179 1273-0063 6.77 µM -0.119490854724911 0.458459739973752 no 1845 0.452443242499746 2629 3108139 SGTC_139 0099-0334 718.624 µM -0.121606491686106 0.45769042314746 no 1846 0.451605336014451 2621 97690 SGTC_2524 avocatin b 10.57 µM -0.122922382630283 0.457212000663419 no 1847 0.451084280630791 2721 6710748 SGTC_3152 9099253 49.47 µM -0.122949963707958 0.457201973587894 no 1848 0.451073360207183 2709 25236131 SGTC_622 1348-1566 26.3 µM -0.123017773992121 0.457177321337049 no 1849 0.451046511630278 2709 7340407 SGTC_475 α-linolenic acid 10 µM -0.123307505728118 0.457071991982118 no 1850 0.45093179874096 2837 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1847 st056231 15 µM -0.123978233123174 0.456828166681028 no 1851 0.45066625476632 2617 5393180 SGTC_612 0302-0167 22.4 µM -0.125225436610793 0.456374821937578 no 1852 0.450172540121383 2693 235821 SGTC_937 3122-0005 46.7 µM -0.127260093012986 0.455635368860575 no 1853 0.449367272300604 2745 759535 SGTC_2827 7993847 71.43 µM -0.128091386121187 0.455333296933205 no 1854 0.449038326386855 2708 2985692 SGTC_664 1222-0054 14.9 µM -0.128145257081357 0.45531372241063 no 1855 0.449017010644554 2664 6813991 SGTC_510 ag-490 170 µM -0.128551072642134 0.455166268980928 no 1856 0.448856441668609 2674 5328779 SGTC_1435 4092-0789 56.7 µM -0.12891906481851 0.455032564049513 no 1857 0.448710845505903 2653 2248285 SGTC_2520 obtusaquinone 4.71 µM -0.129171551503129 0.454940829406607 no 1858 0.448610953103419 2770 5967872 SGTC_2953 9074162 66.49 µM -0.129730226142928 0.454737857671588 no 1859 0.44838993382029 2686 16451992 SGTC_1877 wortmannin 25 µM -0.131880150207791 0.453956880801206 no 1860 0.447539544659695 2704 312145 A covalent inhibitor of PI 3-kinase. SGTC_986 1493-0483 84 µM -0.133009826092898 0.45354658827143 no 1861 0.447092804726514 2627 40079 SGTC_549 1661-1316 519 µM -0.133227029033448 0.453467706938307 no 1862 0.447006917653113 2692 2857282 SGTC_651 3253-0966 34.4 µM -0.133333545800841 0.453429024041511 no 1863 0.446964799364219 2664 781462 SGTC_1703 st026983 48.3 µM -0.133784513928931 0.453265254223287 no 1864 0.44678648659856 2682 1104023 SGTC_1269 0831-0796 3.05 µM -0.133935333058836 0.45321048578009 no 1865 0.44672685512408 2731 927758 SGTC_1191 1487-1166 10.6 µM -0.134504876806658 0.453003669757517 no 1866 0.446501677499548 2764 3955771 SGTC_3038 9091290 49.47 µM -0.135357691404684 0.452694014635497 no 1867 0.446164536788855 2722 25236843 SGTC_1465 k213-0056 144 µM -0.135878684782099 0.452504857218991 no 1868 0.445958593128163 2639 24048857 YMR208W ERG12 SGTC_2716 st080858 38.6235 µM -0.136086679845382 0.452429343319467 no 1869 0.445876378753149 2715 5296050 SGTC_582 0987-0078 156 µM -0.136660051992908 0.452221185917969 no 1870 0.445649753545825 2659 1625765 SGTC_918 glabranin 770.725 nM -0.138411780895896 0.451585318693837 no 1871 0.444957493411948 2697 124049 Also referred to as licorice root. SGTC_1422 4031-0024 15.5 µM -0.13848875689824 0.451557379697321 no 1872 0.444927077346318 2627 782427 SGTC_2256 7954252 200 µM -0.139190497708085 0.451302688878998 no 1873 0.44464980857073 2734 2972920 SGTC_2193 5925765 200 µM -0.139556066713733 0.451170016673231 no 1874 0.444505377255886 2758 877370 SGTC_1214 0358-0031 63.7 µM -0.140218020813637 0.450929794359304 no 1875 0.444243867007259 2950 4301366 SGTC_2032 5185112 25.99 µM -0.140512359739461 0.450822984898795 no 1876 0.444127593855189 2734 5718189 SGTC_1550 gossypolone 36.6 µM -0.141741475600763 0.450377002944586 no 1877 0.443642106433422 2671 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1400 3771-8998 51.5 µM -0.142778607314237 0.450000730726046 no 1878 0.443232516426073 2687 670767 SGTC_2871 9038510 12.99 µM -0.143817529192886 0.449623854094231 no 1879 0.442822280241466 2667 4945164 SGTC_2434 5670830 169.91 µM -0.143893854518826 0.449596168302545 no 1880 0.442792144284405 2746 1549830 SGTC_3163 9099914 49.47 µM -0.144198730238833 0.44948558195825 no 1881 0.442671771794933 2701 16268368 SGTC_1315 1237-0019 3.69 µM -0.145916636885241 0.448862526168561 no 1882 0.441993598913247 2746 825140 SGTC_2341 7987486 176.74 µM -0.146513764577744 0.44864598747016 no 1883 0.441757912305184 2759 1258686 SGTC_2493 resveratrol 26.09 µM -0.147350981752036 0.448342409979268 no 1884 0.441427496994173 2638 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2273 7815444 169.05 µM -0.147505313767674 0.448286452018144 no 1885 0.441366592914398 2810 2824616 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.148427099830971 0.447952250744892 no 1886 0.44100285718197 2662 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_678 1218-2179 85.9 µM -0.149353519420444 0.447616406767914 no 1887 0.440637343203928 2659 6820081 YOR116C RPO31 SGTC_1761 st044296 37 µM -0.150411752370247 0.447232824005821 no 1888 0.440219884850731 2655 1826700 SGTC_33 0986-0033 35.816 µM -0.15043061609933 0.447225986826306 no 1889 0.440212443970277 2666 2848082 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.150458717308843 0.447215801540856 no 1890 0.440201359364414 2812 1273210 SGTC_2061 5245884 80.95 µM -0.15140041614012 0.446874502901767 no 1891 0.439829930607229 2678 573863 SGTC_2238 6671620 73.2395 µM -0.15245406149862 0.446492678281557 no 1892 0.43941441022029 2627 729941 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.152502110997465 0.446475267073635 no 1893 0.439395462788651 2876 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_807 1315-0151 48 µM -0.152858282394729 0.446346208088567 no 1894 0.439255017514035 2717 4011080 SGTC_2692 st077426 47.7 µM -0.153535467357874 0.446100845272625 no 1895 0.438988011481353 2783 25238571 SGTC_2492 derrusnin 100 µM -0.154879359990841 0.445613977060575 no 1896 0.438458212813806 2644 1715307 Part of coumarin class of compounds. SGTC_998 3996-0085 177 µM -0.155305938764243 0.445459452328623 no 1897 0.438290066983294 2748 715391 SGTC_1358 1509-0022 2.48 µM -0.156808632571133 0.444915179731648 no 1898 0.437697834607529 2725 3258434 SGTC_2224 6650123 117.647 µM -0.158993374872866 0.444124056062101 no 1899 0.436837046761213 2683 2908370 SGTC_790 1575-0012 79.1 µM -0.160340287598905 0.443636432117362 no 1900 0.436306512240704 2825 378741 YLR208W SEC13 SGTC_966 1300-0360 30.2 µM -0.161649628887963 0.443162491975351 no 1901 0.435790886514297 2703 70588 SGTC_213 1246-0773 967 nM -0.162155920763531 0.44297925208691 no 1902 0.435591535226395 2729 6251622 SGTC_39 0986-0283 58.349 µM -0.162788816024929 0.442750208372549 no 1903 0.435342357161754 2795 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_884 0851-0618 334 µM -0.163325473745464 0.442556007846129 no 1904 0.435131089020517 2848 9642473 SGTC_26 0302-0163 425.158 µM -0.16388903764663 0.442352085628226 no 1905 0.434909248551753 2690 3100915 SGTC_727 3032-0951 202 µM -0.164120270452757 0.442268419840134 no 1906 0.434818232332598 2773 3652836 SGTC_2443 5493264 126.67 µM -0.165148167849951 0.441896532178527 no 1907 0.43441368050989 2843 5340055 SGTC_847 0342-0274 5.54 µM -0.165165863251659 0.44189013052631 no 1908 0.434406716692064 2824 18097 SGTC_1438 4092-1045 4 µM -0.166291248014208 0.441483032170912 no 1909 0.433963876614688 2696 1351342 SGTC_225 nsc-122657 1.016 µM -0.167566295128982 0.441021869444516 no 1910 0.433462244403957 2811 275685 SGTC_3173 9105693 49.47 µM -0.168108435790764 0.440825810634301 no 1911 0.433248986498792 2841 17096658 SGTC_1007 4101-0031 70 µM -0.16834810670323 0.440739141080774 no 1912 0.433154715097197 2866 1146276 SGTC_360 0957-0399 1.01 µM -0.169045445940524 0.440486986128869 no 1913 0.432880447530991 2840 6752301 YPR165W RHO1 SGTC_2783 7738165 71.43 µM -0.17091959432691 0.439809421766859 no 1914 0.432143494664166 2771 17201110 SGTC_2927 9011802 47.9 µM -0.171432251595813 0.439624110446006 no 1915 0.431941948514058 2823 43912568 SGTC_707 0865-0008 204 µM -0.171793596708958 0.439493502199567 no 1916 0.431799899884962 2731 723043 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.172022188955455 0.439410880897179 no 1917 0.431710042380099 2681 2346 DNA damaging agent; causes G2/M arrest. SGTC_1088 bifonazole 369 nM -0.174006929774539 0.438693636862065 no 1918 0.430930008071917 2683 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_439 amiodarone 34.4 µM -0.174307680963542 0.438584969143448 no 1919 0.430811831557936 2782 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1840 st055363 71 µM -0.174446306624439 0.438534882340131 no 1920 0.430757362379348 2760 676033 SGTC_1850 st056238 17 µM -0.174943265969393 0.438355334177481 no 1921 0.430562106569447 2680 5393177 SGTC_1539 benzyladenosine 56 µM -0.174981034085793 0.438341689322213 no 1922 0.430547268133244 2703 92208 A nucleotide analog. SGTC_1010 4112-3296 15.2 µM -0.176160675457899 0.437915545771334 no 1923 0.430083857018276 2879 704384 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.177439711244861 0.437453577506454 no 1924 0.429581508555324 2839 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2427 5545055 42.75 µM -0.178041039798191 0.437236416206502 no 1925 0.429345372747929 2738 5372858 SGTC_3225 9130819 49.47 µM -0.179145461266339 0.436837619317584 no 1926 0.428911743213772 2768 4547121 SGTC_3168 9103419 49.47 µM -0.17992672848023 0.436555549324926 no 1927 0.428605045667065 2702 16649256 SGTC_3149 9097855 49.47 µM -0.18164298042338 0.435936024374759 no 1928 0.427931458200868 2871 25236625 YMR079W SEC14 SGTC_1941 st076221 61.8 µM -0.181849947057917 0.435861325073723 no 1929 0.42785024294002 2899 2828568 SGTC_2451 5856223 45.7 µM -0.182712058892778 0.435550192552789 no 1930 0.427511976707402 2769 2179896 SGTC_1744 st037937 38.9 µM -0.183276442070233 0.435346530639818 no 1931 0.427290558906281 2897 1016152 SGTC_1909 st060837 51.5 µM -0.183370330673538 0.435312651893626 no 1932 0.427253726916955 2790 678937 SGTC_500 h-89 112 µM -0.183790422600268 0.43516107181934 no 1933 0.427088934905381 2911 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_729 4092-0585 94.1 µM -0.184888926524933 0.434764748168667 no 1934 0.426658078303288 2728 2169061 SGTC_224 benfluorex 43.875 µM -0.1852205992174 0.43464509852639 no 1935 0.426528006393946 2802 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1793 st048256 72.231 µM -0.185511365100103 0.434540210780956 no 1936 0.426413983459639 2700 672022 SGTC_2745 rifampicin 24.3 µM -0.185525384917434 0.434535153539783 no 1937 0.426408485787334 2821 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_851 0394-0702 453 µM -0.186750304931293 0.434093340730326 no 1938 0.425928206115527 2759 762646 SGTC_308 4092-1169 104 µM -0.187294386088622 0.433897124061373 no 1939 0.425714912179016 2761 2268590 YDL196W YDL196W SGTC_3340 9146634 11.102 µM -0.188796558499152 0.433355467407371 no 1940 0.425126134628414 2812 4907387 SGTC_2295 7971645 200 µM -0.189286469679055 0.433178841165345 no 1941 0.424934149633152 2816 2978226 YKL099C UTP11 SGTC_1474 0330-0125 5.35 µM -0.189783638465018 0.432999612004584 no 1942 0.424739338748335 2779 X1474 SGTC_2588 indole-3-carbinol 100 µM -0.191104223556235 0.432523608590029 no 1943 0.424221969351701 2882 3712 Induces cell cycle arrest. SGTC_1895 st058434 18.3 µM -0.191858214061465 0.432251877423912 no 1944 0.42392663482851 2922 5393175 SGTC_1051 3253-3903 78 µM -0.192847303629933 0.431895467348945 no 1945 0.423539277913961 2710 5509239 SGTC_832 4083-0019 164 µM -0.193412457186651 0.431691843900442 no 1946 0.42331798010314 2872 1990758 SGTC_251 melphalan 456.522 µM -0.193518453038676 0.431653655872878 no 1947 0.423276477880363 2814 460612 A DNA alkylator. SGTC_2960 9079389 5.97 µM -0.195726274347344 0.430858371041244 no 1948 0.422412209095309 2888 16457355 SGTC_3195 9113082 49.47 µM -0.196773517501078 0.430481238777547 no 1949 0.422002387949632 2759 17018038 SGTC_2045 5106652 78.05 µM -0.198820932447057 0.429744108989438 no 1950 0.421201410573371 2894 673349 SGTC_763 3453-1109 128 µM -0.198852990057428 0.429732569244091 no 1951 0.421188871771245 2853 1560353 SGTC_2863 9028737 58.44 µM -0.199529782285785 0.429488959062635 no 1952 0.420924174402251 2865 6460917 SGTC_2125 5246583 200 µM -0.199652857251481 0.429444661325972 no 1953 0.420876042906235 2824 835267 SGTC_329 k048-0121 21.3 µM -0.200115293077727 0.429278227132348 no 1954 0.420695206565075 2845 6832902 SGTC_2080 5212524 12.4 µM -0.202471689355613 0.428430337924502 no 1955 0.419773994338706 2763 260183 SGTC_2399 5884133 200 µM -0.20272863042658 0.428337904121031 no 1956 0.419673571986449 2791 722445 SGTC_19 0279-0214 38.434 µM -0.2031447466031 0.428188215877295 no 1957 0.419510949041199 2739 3566274 YBR002C RER2 SGTC_980 1473-0395 201 µM -0.203606701097157 0.42802205045416 no 1958 0.419330428061098 2766 768876 SGTC_945 3381-0768 11.3 µM -0.205687503901922 0.427273742557124 no 1959 0.418517510147047 2890 1126236 YIL048W NEO1 SGTC_1118 chelidonine 707.474 nM -0.206060613765464 0.427139590649136 no 1960 0.418371782082438 2847 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_544 k015-0020 52.4 µM -0.206414008397268 0.427012535135538 no 1961 0.418233764661317 2805 3008304 SGTC_3287 9117173 37.0625 µM -0.206808403590853 0.4268707476839 no 1962 0.418079746457601 2813 2789709 SGTC_2531 methyl deoxycholate 70.07 µM -0.208210174464637 0.42636687918898 no 1963 0.417532432302103 2776 16667744 Haematoxylin. SGTC_1180 1193-0155 285 µM -0.208280228050773 0.426341701475621 no 1964 0.417505084425167 2913 2921347 SGTC_1207 2099-0101 141 µM -0.208449788469051 0.426280761604056 no 1965 0.417438892214615 2879 5837381 SGTC_757 1066-0008 322 µM -0.209516997188864 0.425897248148471 no 1966 0.417022333993662 2939 6842497 SGTC_1091 telmisartan 47.6 µM -0.210188004231927 0.425656150082574 no 1967 0.416760470841812 2882 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2323 6148992 148.28 µM -0.211826523101219 0.425067534440121 no 1968 0.416121187793426 2842 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1848 st056003 16.4 µM -0.214100282842697 0.424250994088821 no 1969 0.415234427616902 2775 146492 SGTC_2311 7694451 200 µM -0.21493393860879 0.423951697366171 no 1970 0.414909412007391 2872 2163142 SGTC_2037 5169046 200 µM -0.215273492588792 0.423829804222238 no 1971 0.414777047492803 2894 5718022 SGTC_249 wiskostatin 11.211 µM -0.2155550569504 0.423728733727505 no 1972 0.414667295756952 2797 2775510 A n-wasp and actin depolymerizer. SGTC_2694 st077685 81.9 µM -0.216007222764505 0.423566434544752 no 1973 0.414491058759361 2756 2838096 SGTC_2908 7930301 100 µM -0.216996853195586 0.423211264537759 no 1974 0.414105398651036 2783 2223178 SGTC_1789 tunicamycin 25 nM -0.218124801744416 0.422806529423857 no 1975 0.413665936815286 2904 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1097 itavastatin 7.23 µM -0.219706377211472 0.422239159338651 no 1976 0.413049918860695 2823 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1440 4100-1550 40 µM -0.220153902615661 0.422078644523255 no 1977 0.412875648109554 2794 742806 SGTC_1922 5578187 25 µM -0.221565173896531 0.421572545963839 no 1978 0.412326197924422 3033 1350412 SGTC_890 0929-0006 47.2 µM -0.222161547394732 0.42135871826301 no 1979 0.41209406342956 2809 1378169 SGTC_1971 st069429 63.5 µM -0.222172751021114 0.421354701462389 no 1980 0.412089702785111 2943 1246522 YGL099W LSG1 SGTC_1546 5-methoxyflavanone 78.7 µM -0.222615289642139 0.421196046045459 no 1981 0.411917467815198 2878 147795 SGTC_2333 9017922 200 µM -0.222882671484007 0.421100192639267 no 1982 0.411813411664302 2937 3163164 SGTC_1102 cgs 12066b 26.1 µM -0.224039647443448 0.420685483638159 no 1983 0.411363226525582 2853 6438352 A 5-HT1B full agonist. SGTC_208 k072-0098 12.366 µM -0.224852036886293 0.42039434155059 no 1984 0.411047191418034 2795 5948901 SGTC_662 k832-1615 104 µM -0.225497185293288 0.420163165899435 no 1985 0.410796257400484 2885 5878478 SGTC_1935 st074532 41.6 µM -0.226316370435149 0.419869667462594 no 1986 0.410477683453448 2931 2829742 SGTC_1119 parthenolide 318.541 nM -0.226511056879321 0.419799921564664 no 1987 0.410401980273545 3006 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2053 5265679 138 µM -0.226567867682237 0.419779569721146 no 1988 0.410379890209813 2796 764595 SGTC_771 0250-0039 27.3 µM -0.226733189697857 0.419720346153371 no 1989 0.410315608739355 2807 3005115 SGTC_2034 5197015 53.07 µM -0.228360994731591 0.419137312267358 no 1990 0.409682805013856 2955 780676 SGTC_869 0564-0080 44.1 µM -0.229601565652522 0.41869309385604 no 1991 0.409200695080553 2844 6843321 SGTC_1609 st001574 46.4 µM -0.229699329115692 0.41865809152575 no 1992 0.409162708128929 2810 3960012 SGTC_1951 sophoraflavanone G 9.2 µM -0.229840541478385 0.418607534288458 no 1993 0.409107840187664 2794 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_220 paclitaxel 373.376 µM -0.230478637362568 0.41837909822524 no 1994 0.408859930803449 2917 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2277 7947813 106.88 µM -0.23056143283846 0.418349459754464 no 1995 0.408827766246059 3045 1246798 SGTC_2140 5586273 200 µM -0.230588378903178 0.418339813914942 no 1996 0.408817298315633 2793 854421 SGTC_737 1950-0117 57.9 µM -0.230686115585478 0.418304827683854 no 1997 0.408779330393698 2918 5393513 SGTC_579 4491-1009 110 µM -0.231474708933317 0.418022563184649 no 1998 0.408473015649297 2873 1271041 SGTC_426 0988-0037 14.6 µM -0.231836503205088 0.41789307877469 no 1999 0.408332501942403 2943 5383008 SGTC_1193 1488-0126 41.5 µM -0.23286019058756 0.417526754303332 no 2000 0.407934986009221 2844 1384710 SGTC_1878 temozolomide 1 mM -0.233082189847671 0.417447321746223 no 2001 0.407848792254315 2866 5394 DNA alkylating agent. SGTC_2563 tomatine 8.54 µM -0.233931194295513 0.417143574385437 no 2002 0.407519197732894 2867 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1800 st050079 29.0735 µM -0.234003979097202 0.41711753654794 no 2003 0.407490944773309 2917 3645560 SGTC_2445 5742597 35.57 µM -0.234117607757406 0.417076888066072 no 2004 0.407446838368584 2817 1774255 SGTC_95 0471-0001 561.058 µM -0.234357200834566 0.41699118112651 no 2005 0.407353841124775 2841 4015405 SGTC_939 1165-0479 45.3 µM -0.234971825116269 0.416771336536757 no 2006 0.40711530067608 2905 1377347 SGTC_667 1498-1044 59 µM -0.236440168990618 0.416246230983359 no 2007 0.40654556464397 2866 6739982 SGTC_2048 5246248 200 µM -0.23772113904496 0.415788255626898 no 2008 0.40604869350793 2918 677046 SGTC_2616 abietic acid 100 µM -0.237794500248121 0.415762030817055 no 2009 0.406020242252 2927 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1423 4048-0112 5.59 µM -0.237848744223644 0.415742640182981 no 2010 0.405999205440312 2900 X1423 SGTC_2151 5563267 85.4165 µM -0.238064776418426 0.415665417030342 no 2011 0.405915426874107 2855 5310824 SGTC_484 loperamide 105 µM -0.238750799660936 0.415420211865168 no 2012 0.405649411575693 2788 3955 An opioid-receptor agonist. SGTC_3133 9127736 49.47 µM -0.240145734192945 0.41492172233113 no 2013 0.405108640295701 2870 27243420 SGTC_1472 k841-0093 193 µM -0.241331823910126 0.414497972637248 no 2014 0.404648973874431 2934 X1472 SGTC_2669 eugenol 100 µM -0.242230200749658 0.414177079201897 no 2015 0.404300897462711 2900 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_836 0330-0104 1.35 µM -0.242526945946667 0.414071096629796 no 2016 0.404185940062708 2837 46494820 SGTC_1425 4048-4433 7.33 µM -0.243200293301704 0.413830633785672 no 2017 0.403925119830123 2895 23734946 SGTC_2999 9069765 71.4286 µM -0.244538986084117 0.413352661756082 no 2018 0.403406705868265 2925 2097066 SGTC_1319 1306-0155 43.7 µM -0.245473646792771 0.413019022960122 no 2019 0.403044855430894 2831 3122360 SGTC_1456 k015-0012 13 µM -0.245987733955011 0.412835539897324 no 2020 0.402845863853779 2954 2989616 SGTC_804 1595-0054 20.9 µM -0.2483153770035 0.412005018704274 no 2021 0.401945201198036 2858 761523 Stimulates phospholipase C. SGTC_2041 5107442 45.335 µM -0.248623283582439 0.411895184660875 no 2022 0.401826098112769 3001 793005 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.249026526930395 0.411751353265306 no 2023 0.401670131063159 2863 115019 SGTC_1367 1812-0510 76.9 µM -0.249046189964409 0.411744340032605 no 2024 0.401662526166479 2889 1142582 YDR527W RBA50 SGTC_1838 st055369 84.5 µM -0.24945495352836 0.411598552338931 no 2025 0.401504440758762 2820 676036 SGTC_1087 pterostilbene 9.05 µM -0.250165202509529 0.411345267307173 no 2026 0.40122979709321 2980 5281727 Similar to reservatol, lowers cholesterol. SGTC_1491 4138-0063 26.5 µM -0.250317673509053 0.411290898762852 no 2027 0.401170844979156 2848 23883227 SGTC_3053 9095903 49.47 µM -0.250827750598876 0.411109026406521 no 2028 0.400973642702811 2905 17174018 SGTC_3194 9111903 49.47 µM -0.251057353532455 0.411027165746429 no 2029 0.400884883525992 3047 17087251 SGTC_289 k017-0060 526 µM -0.25224922884028 0.410602287083632 no 2030 0.400424214445041 2856 5512909 SGTC_3200 9114385 49.47 µM -0.253206709084411 0.41026104131584 no 2031 0.400054241157954 2997 17018030 YLR208W SEC13 SGTC_2619 obliquin 87.91 µM -0.253351547777504 0.410209426744037 no 2032 0.39999828284683 2851 6708593 A bioactive alkalod. YER133W GLC7 SGTC_422 cantharidin 155 µM -0.2544426725828 0.409820644655571 no 2033 0.399576793744033 2815 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2606 farnesol 9.78 µM -0.255465034692082 0.409456444049771 no 2034 0.399181973053149 3041 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1184 1269-1718 139 µM -0.257128428187937 0.408864053073627 no 2035 0.398539816310651 3003 5403821 SGTC_2036 5160441 105 µM -0.258575664949029 0.408348812117584 no 2036 0.397981330684499 2907 134534 YIL048W NEO1 SGTC_1253 0550-0034 176 µM -0.258831349157207 0.40825780062075 no 2037 0.39788268437387 2985 5969915 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.259180756771386 0.408133436022979 no 2038 0.397747888905034 2904 4330530 SGTC_634 1611-4317 11.2 µM -0.261173684449383 0.40742427085958 no 2039 0.396979285390326 2862 2843522 SGTC_568 1193-0097 7.48 µM -0.261302482398968 0.407378449691877 no 2040 0.396929626189244 2970 3646150 SGTC_1954 st077032 68.9 µM -0.261409335358428 0.407340436637226 no 2041 0.396888429343677 2942 698907 SGTC_2642 cholecalciferol 100 µM -0.261683871269238 0.407242774195175 no 2042 0.396782588104683 2964 9821465 A vitamin D precursor, similar to steriods. SGTC_363 0455-0021 3.06 µM -0.262204728981508 0.407057501951515 no 2043 0.396581803854883 2856 4597466 SGTC_2414 st077232 92.9 µM -0.262292837668289 0.407026163213133 no 2044 0.396547841748539 2831 729801 SGTC_1901 st060216 58.6 µM -0.263647889633239 0.406544269717712 no 2045 0.396025626543771 2855 688792 SGTC_443 clozapine 122 µM -0.265054877580125 0.406044056108288 no 2046 0.395483593452483 2857 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1790 st045711 43.5 µM -0.267663134612517 0.405117172417791 no 2047 0.394479314485781 3038 585119 SGTC_473 2-arachidonoylglycerol 10 µM -0.26847518031235 0.404828708012768 no 2048 0.394166788530113 2823 5282280 An endocannabinoid. SGTC_2375 9072683 200 µM -0.268705566041738 0.404746877099665 no 2049 0.39407813409516 3047 16798029 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.27075823995448 0.40401797031688 no 2050 0.393288490084765 2982 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3265 9137266 49.47 µM -0.271199284475913 0.403861398311293 no 2051 0.39311888163557 2965 17224265 SGTC_665 3914-0008 307 µM -0.273435618032901 0.403067731366959 no 2052 0.392259188182625 2893 1069549 SGTC_2641 levomentholum 100 µM -0.273591410436806 0.403012456023914 no 2053 0.392199317854745 2951 16666 SGTC_1138 3761-0006 1.03 µM -0.274677122171316 0.402627297995781 no 2054 0.391782154596896 2873 12061087 SGTC_1568 digitonin 820 nM -0.276583998351008 0.401951059452954 no 2055 0.391049776506134 3055 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2553 4-methylesculetin 85.09 µM -0.277942074827551 0.401469621404001 no 2056 0.39052841241855 2948 5319502 SGTC_1811 st050069 61.5 µM -0.279057841124144 0.401074194157212 no 2057 0.390100218139756 2909 3877702 SGTC_845 0330-0138 4.51 µM -0.279329100180167 0.400978075322452 no 2058 0.389996137991619 2973 9039800 SGTC_3237 9133362 49.47 µM -0.280706987194589 0.400489922927384 no 2059 0.389467574572063 3015 43845137 SGTC_2808 7946468 45.46 µM -0.28129723500061 0.400280859749214 no 2060 0.389241215439732 2984 2970879 SGTC_1824 st053723 68.6 µM -0.282440359796939 0.399876051267668 no 2061 0.388802935758521 2960 675225 SGTC_31 0508-1974 57.237 µM -0.282753189970485 0.399765289173398 no 2062 0.388683019762891 3016 6810525 SGTC_3328 9140624 29.0385 µM -0.283722214310445 0.399422243166671 no 2063 0.388311634724756 3070 4904392 SGTC_1938 st074717 56.4 µM -0.28458639109934 0.399116379909229 no 2064 0.387980519320164 2857 17250979 SGTC_1689 st020265 53.493 µM -0.286847030200653 0.398316551731996 no 2065 0.387114725244517 3041 5758320 YPR016C TIF6 SGTC_3269 9137823 49.47 µM -0.288565113319599 0.397708968623104 no 2066 0.386457097887145 2889 17682936 SGTC_2428 5615643 7.78 µM -0.288888012090674 0.397594806309992 no 2067 0.386333538881476 3041 2253075 SGTC_709 3807-1509 243 µM -0.289653052337125 0.397324357910961 no 2068 0.386040838011415 2904 1886677 YPL242C IQG1 SGTC_1306 1185-0270 9.02 µM -0.290152555152739 0.397147805933633 no 2069 0.38584976552341 3029 1548076 SGTC_351 caspofungin 25 nM -0.291300874502178 0.396742006205192 no 2070 0.385410609339289 2944 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.291784004353839 0.396571308374325 no 2071 0.385225887998698 2927 279621 SGTC_2877 9040724 71.43 µM -0.294202377121207 0.395717155505596 no 2072 0.384301632153627 3122 6463895 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.296273557505996 0.394986026388547 no 2073 0.383510588991431 2940 688669 SGTC_2720 fluspirilene 36.88 µM -0.296343265231726 0.394961425894143 no 2074 0.383483974036227 3015 3396 An atypical antipsychotic. SGTC_1157 4092-0394 27.6 µM -0.296785225305157 0.39480546388655 no 2075 0.383315243019496 3114 3659885 SGTC_1692 fluoroquinolonic acid 71 µM -0.297963044895982 0.394389908931043 no 2076 0.382865684546596 3052 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_22 0964-0034 14.468 µM -0.298186219293897 0.394311182702938 no 2077 0.382780519530441 2957 138402 SGTC_888 0916-0002 6.97 µM -0.299533882589799 0.393835877522128 no 2078 0.382266361735372 3103 2802138 YIL048W NEO1 SGTC_105 0111-0055 734.78 µM -0.300114476701369 0.39363115741604 no 2079 0.382044918541786 3025 5179370 SGTC_2446 5162541 200 µM -0.301431094627979 0.393167020994065 no 2080 0.381542893090801 2905 1549321 SGTC_1117 retinoic acid 1.10837 µM -0.301465993398644 0.3931547204817 no 2081 0.381529588921618 3097 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1419 3993-2473 62.6 µM -0.302315224920997 0.392855431016302 no 2082 0.38120588660463 2967 704026 SGTC_1760 st045453 10.4495 µM -0.302842097567811 0.392669780338904 no 2083 0.381005099855429 3069 3323419 YIL048W NEO1 SGTC_2635 hydroquinidine 100 µM -0.303026633635628 0.392604762340124 no 2084 0.38093478227924 2909 442912 An experimental heart treatment. SGTC_3132 9126706 49.47 µM -0.305184961150624 0.391844537030354 no 2085 0.380112642831777 3148 850858 SGTC_3242 9133940 49.47 µM -0.305610989718835 0.391694526147476 no 2086 0.379950426000691 3088 17248444 SGTC_1449 4112-4002 201 µM -0.306326009175767 0.391442793552117 no 2087 0.379678218991244 2973 2059539 SGTC_2513 baicalein 25.65 µM -0.306327256095793 0.391442354596166 no 2088 0.37967774434239 2994 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2795 7780010 54.55 µM -0.30651026422541 0.391377931348288 no 2089 0.379608082980643 3079 953673 SGTC_1658 st012944 20 µM -0.306616266696813 0.391340617300348 no 2090 0.379567735322378 3026 24207260 SGTC_2040 5100729 123 µM -0.307953921176151 0.390869834092775 no 2091 0.379058697507911 2943 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3040 9091894 49.47 µM -0.308145436228069 0.390802444053125 no 2092 0.378985834536825 2942 25236966 SGTC_2532 xanthone 78.9 µM -0.308958881967874 0.390516246510131 no 2093 0.378676402508859 3051 7020 An insecticide. SGTC_1121 fusaric acid 630.51 nM -0.310046832986662 0.39013356151875 no 2094 0.37826267117145 2967 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1379 2144-0755 36.5 µM -0.310071077081182 0.390125034909262 no 2095 0.378253453096254 3136 5392327 SGTC_1063 disulfiram 1.84 µM -0.310640016747335 0.389924954917509 no 2096 0.378037151099251 2959 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2661 dactinomycin 12.96 µM -0.312332562510897 0.389329907045726 no 2097 0.377393897820603 2989 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3137 9097352 49.47 µM -0.31260009892915 0.389235873044988 no 2098 0.377292251477885 3251 44120435 SGTC_336 4111-0029 111 µM -0.314341344135449 0.388624016946429 no 2099 0.376630900169836 2986 3131175 SGTC_1335 1486-0900 202 µM -0.315971393638038 0.388051484176747 no 2100 0.376012110600871 2925 X1335 SGTC_2068 5226020 147 µM -0.318007264130815 0.387336754015832 no 2101 0.375239713373338 3014 1810509 SGTC_3202 9113761 49.47 µM -0.319975103784893 0.386646270090178 no 2102 0.374493601739779 3122 4798415 SGTC_3323 9138564 53.9225 µM -0.321292032680715 0.386184380696956 no 2103 0.373994546809605 3146 43912313 YNL103W MET4 SGTC_1780 st038448 24.544 µM -0.321296609179599 0.38618277585215 no 2104 0.373992812896583 3147 728868 YDL195W SEC31 SGTC_766 1391-0721 126 µM -0.32227753635871 0.385838838256955 no 2105 0.373621224717236 3122 1020919 YIL115C NUP159 SGTC_1163 k060-0048 49.9 µM -0.32396834861812 0.38524620795594 no 2106 0.372980998574827 2971 6809982 SGTC_587 k089-0003 57 µM -0.32418182482723 0.385171403486636 no 2107 0.372900190691403 2992 9659696 SGTC_2326 6164455 177.58 µM -0.328032039964656 0.383822980725928 no 2108 0.371443718687536 3040 2888790 SGTC_2986 9022445 71.43 µM -0.330837061656727 0.382841489637882 no 2109 0.37038378230992 3157 6459286 SGTC_1911 st060208 74.3 µM -0.331875327255008 0.382478385634634 no 2110 0.369991700753974 3087 688783 SGTC_778 3456-2434 196 µM -0.333890938124053 0.381773777966258 no 2111 0.36923092905195 3120 5539063 SGTC_2645 abamectin 100 µM -0.334264346183158 0.381643286666643 no 2112 0.369090046110928 3109 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_650 1328-0195 38 µM -0.334625202535916 0.381517194469338 no 2113 0.368953915503617 3101 2780821 SGTC_472 calcifediol 10 µM -0.33508920255734 0.381355079784582 no 2114 0.368778898806025 3041 5283731 A vitamin D metabolite. SGTC_506 n9-isopropylolomoucine 153 µM -0.335146697425618 0.381334993384255 no 2115 0.368757214145053 3131 6610355 SGTC_2132 5317594 122.667 µM -0.337038717644055 0.38067417605772 no 2116 0.368043856702827 2980 794577 SGTC_675 1309-0189 238 µM -0.337130631018637 0.38064208273752 no 2117 0.368009213727233 3036 4246530 SGTC_143 4032-1194 15.74 µM -0.337703032876809 0.380442236127102 no 2118 0.367793494499736 2932 1806963 SGTC_2271 7849410 118.62 µM -0.338732194928223 0.380082997963001 no 2119 0.367405742461609 3132 972430 SGTC_358 0075-0058 9.45 µM -0.339308704006997 0.379881807521282 no 2120 0.367188593167203 3147 1069125 SGTC_3181 9108277 49.47 µM -0.343049048477642 0.378577291989158 no 2121 0.365780780569628 3015 17097298 SGTC_1303 1160-0052 261 µM -0.343881361437304 0.378287194691945 no 2122 0.365467754714504 3041 3562476 SGTC_2156 5649887 115 µM -0.344462273241602 0.378084762275704 no 2123 0.365249331773414 3111 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1485 3909-9022 254 µM -0.344462292680611 0.378084755502283 no 2124 0.365249324465074 3070 714516 SGTC_1999 st074831 12.5 µM -0.346634693449554 0.377328028232914 no 2125 0.364432889226619 3025 17112523 SGTC_2105 5350118 200 µM -0.348005772724227 0.376850672903948 no 2126 0.363917924077803 3035 2133313 SGTC_512 prima-1 270 µM -0.348404491711272 0.376711890083714 no 2127 0.36376821485029 3164 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1663 st014140 55.4 µM -0.348777873263794 0.376581940953327 no 2128 0.363628038064555 3063 4207120 SGTC_781 4335-2806 94.4 µM -0.348805476732572 0.376572334588138 no 2129 0.36361767575548 3154 845254 SGTC_172 1112-0046 2.638 µM -0.350192694242038 0.376089663461013 no 2130 0.363097044608831 3030 2802135 YIL048W NEO1 SGTC_397 arbidol 50 µM -0.352153521896499 0.375407739964636 no 2131 0.362361565609873 3166 131410 A RNA synthesis inhibitor. SGTC_2071 5230951 39.92 µM -0.352505326331583 0.37528543288578 no 2132 0.362229662334747 3102 1799272 SGTC_318 1488-0629 67.2 µM -0.35361755225442 0.374898842896721 no 2133 0.361812759220899 3105 3662576 SGTC_1880 MG-132 525 µM -0.354047071235088 0.374749583336924 no 2134 0.361651803590313 3152 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_743 1275-0778 158 µM -0.354050339886174 0.374748447539531 no 2135 0.361650578807403 3113 2849257 YMR203W TOM40 SGTC_1803 st050068 52.4 µM -0.354170264991348 0.374706776476289 no 2136 0.361605643140725 3124 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_385 1494-0393 12.4 µM -0.355493212728428 0.374247181437562 no 2137 0.36111006438573 3069 3090647 SGTC_3107 9121808 49.47 µM -0.356127704152931 0.374026821028711 no 2138 0.360872465313511 3058 662681 SGTC_227 fluconazole 33.516 µM -0.358548957233614 0.373186292760613 no 2139 0.359966268605489 3077 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2870 9038528 12.99 µM -0.360049880541646 0.372665555830116 no 2140 0.359404916085949 3151 6463316 SGTC_2473 5854593 8.94 µM -0.360073727658876 0.372657284081482 no 2141 0.359395999594316 2982 2872951 SGTC_1322 1348-1070 12 µM -0.360355372275329 0.372559595648861 no 2142 0.359290697821616 3157 6758089 SGTC_2366 9070441 60.58 µM -0.360830942148848 0.372394662852823 no 2143 0.3591129152022 3037 6837235 SGTC_2016 5121758 140 µM -0.362517582503303 0.371809906518944 no 2144 0.358482643436107 3020 2795203 SGTC_480 am 92016 50 µM -0.362581265412277 0.371787833508346 no 2145 0.358458853642567 3111 2129 K+ channel blocker. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.363388122122346 0.371508206975778 no 2146 0.358157486702276 3163 688662 SGTC_2275 7947463 200 µM -0.363578328893756 0.37144229825077 no 2147 0.358086455930469 3181 1225414 SGTC_2746 daunorubicin 9.88 µM -0.364315378647082 0.371186938072713 no 2148 0.357811258659688 3093 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_482 fipronil 114 µM -0.365294980348272 0.370847630490204 no 2149 0.357445612501693 3105 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2591 skatole 100 µM -0.365475023200427 0.370785279421928 no 2150 0.357378423924157 3161 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_414 piperonyl butoxide 100 µM -0.366992136435412 0.37026001923318 no 2151 0.35681244180458 3050 5794 A potent inhibitor of cytochrome P450. SGTC_3076 9116187 49.47 µM -0.367808556275648 0.369977455558948 no 2152 0.356507994301605 3154 27241210 SGTC_3024 9090631 49.47 µM -0.368816266407445 0.369628782910093 no 2153 0.356132339645451 3181 25236383 SGTC_1701 st028638 40.4 µM -0.368871719179821 0.369609599087419 no 2154 0.356111671983969 3175 3490878 SGTC_658 3253-0951 102 µM -0.368962268813789 0.369578274243683 no 2155 0.356077924369437 3098 1184878 SGTC_346 4513-0042 7.16 µM -0.369820486942601 0.369281424293878 no 2156 0.355758124707967 3013 2827372 SGTC_996 3970-0799 1.8 µM -0.370305165046031 0.369113812906766 no 2157 0.355577562894311 3115 6615648 YGL040C HEM2 SGTC_1814 st052110 31.539 µM -0.370526526013176 0.369037270130147 no 2158 0.355495107933039 3188 674163 SGTC_3264 9137442 49.47 µM -0.371394134972413 0.368737316116371 no 2159 0.355171996660246 3288 17015726 SGTC_861 0443-0273 110 µM -0.37384518715238 0.367890358858274 no 2160 0.354259749266935 3156 6149169 SGTC_2023 5144124 124 µM -0.374663407437982 0.367607766817237 no 2161 0.353955404883207 3046 2830192 SGTC_1503 4585-0012 61.3 µM -0.374668740323383 0.367605925212004 no 2162 0.353953421574377 3229 2922052 SGTC_886 0866-0150 153 µM -0.376700721933828 0.366904442966138 no 2163 0.353198013144945 3232 271463 SGTC_3015 9080845 49.47 µM -0.376730909154061 0.366894025053646 no 2164 0.353186795110207 3201 5296973 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.377579188974761 0.366601315286701 no 2165 0.35287161349334 3186 521171 SGTC_670 4204-0025 119 µM -0.37763216793007 0.36658303679454 no 2166 0.352851932306286 3159 719039 SGTC_1594 piperine 70.1 µM -0.379107686306536 0.366074083700351 no 2167 0.352303949376248 3054 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_560 2332-1943 155 µM -0.379368615899628 0.365984105291579 no 2168 0.352207076332935 3079 21177716 SGTC_3112 9123419 49.47 µM -0.380217288438266 0.365691501841795 no 2169 0.351892063459092 3050 17015854 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.380691701720849 0.365527968706404 no 2170 0.351716013556315 2986 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3239 9133757 49.47 µM -0.381867119453692 0.365122900433537 no 2171 0.351279965131253 3072 17036923 SGTC_2991 9074669 71.4286 µM -0.382167506083619 0.365019406382241 no 2172 0.351168561128156 3253 17333109 SGTC_1728 st035614 33.7865 µM -0.382505891829447 0.364902832038893 no 2173 0.351043079759374 3115 15945546 SGTC_777 1315-0167 517 µM -0.382588845246788 0.364874256380722 no 2174 0.35101232116536 3139 4221767 SGTC_3099 9120367 49.47 µM -0.38263232663637 0.364859278282227 no 2175 0.350996198935483 3055 24824940 SGTC_1288 0973-0013 65.5 µM -0.383065478514407 0.364710081078812 no 2176 0.350835607536732 3195 4315430 SGTC_3121 9125696 49.47 µM -0.383344312737248 0.364614048730721 no 2177 0.350732243624498 3117 1235365 SGTC_2703 st077852 53.4 µM -0.384848702527792 0.36409607365018 no 2178 0.350174756748082 3182 6281836 SGTC_2620 irigenin 100 µM -0.385370488748148 0.363916475828656 no 2179 0.34998147195342 3252 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_168 3970-0862 530.542 µM -0.385707248421697 0.363800579659313 no 2180 0.349856747005741 3168 3135186 SGTC_1134 3477-0009 42.5 µM -0.388595769776374 0.362807005001713 no 2181 0.34878759827299 3306 3973534 SGTC_814 3342-0569 96 µM -0.390584169758458 0.362123584081669 no 2182 0.348052314345886 3159 4346283 SGTC_1355 1499-0035 1.68 µM -0.392904795350289 0.361326531535849 no 2183 0.34719489982755 3083 1548538 SGTC_2938 9059746 27.26 µM -0.393678439229795 0.36106094584159 no 2184 0.346909230780875 3197 6471769 SGTC_3164 9100705 49.47 µM -0.395791475235844 0.360335899214786 no 2185 0.346129433083086 3231 17174235 SGTC_1904 st060225 78 µM -0.397637941449051 0.359702731606649 no 2186 0.345448544283068 3174 66595 SGTC_1249 0481-0015 10.2 µM -0.397784909898188 0.359652351497925 no 2187 0.345394370764107 3054 4227577 SGTC_2449 5812982 45.77 µM -0.398431024143894 0.359430895445407 no 2188 0.345156246462131 3189 776185 SGTC_1482 3346-2049 8.48 µM -0.398447310214632 0.359425313994354 no 2189 0.345150245050171 3194 3826804 SGTC_985 1493-0307 8.71 µM -0.398559526405322 0.35938685684244 no 2190 0.345108894477783 3255 3278274 SGTC_3002 9075603 71.4286 µM -0.39887803074466 0.359277711282174 no 2191 0.344991538808707 3146 20105405 SGTC_3229 9132204 49.47 µM -0.399867965671887 0.35893855218926 no 2192 0.344626883974112 3099 17682924 SGTC_1080 nisoldipine 24.4 µM -0.400403786825864 0.358755022217034 no 2193 0.344429567770889 3032 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3310 9130229 44.1445 µM -0.400568841633291 0.3586984940544 no 2194 0.344368794844091 3227 7761258 SGTC_700 3453-2283 142 µM -0.400744238749767 0.358638427237863 no 2195 0.344304218298455 3274 565664 SGTC_904 1141-0088 396 µM -0.403145940525816 0.357816288369714 no 2196 0.343420432984029 3138 1378119 SGTC_3215 9129942 49.47 µM -0.403491233341321 0.357698143518182 no 2197 0.343293441336222 3229 17682944 SGTC_142 0335-0849 62.6745 µM -0.404323478988255 0.357413439691848 no 2198 0.342987431112446 3267 3889043 YPR107C YTH1 SGTC_1723 st034307 2.5525 µM -0.404784510180957 0.357255759165387 no 2199 0.34281795784572 3168 867466 SGTC_80 0159-0065 512.242 µM -0.405053705290931 0.357163701117467 no 2200 0.342719017395626 3216 1548079 SGTC_2208 7283366 200 µM -0.408083860460322 0.356128037891248 no 2201 0.341606054327926 3207 898663 SGTC_1187 1391-0724 117 µM -0.408981142487756 0.35582156303792 no 2202 0.341276750023426 3182 6997986 SGTC_3109 9122853 49.47 µM -0.409887977328956 0.355511919983374 no 2203 0.340944062577336 3174 1234709 SGTC_2113 5491891 107.031 µM -0.41253085498024 0.354610041347872 no 2204 0.339975185009493 3167 789979 SGTC_1602 st001878 87.6 µM -0.416693554358829 0.353191178613172 no 2205 0.338451284790992 3286 595405 YLR310C CDC25 SGTC_1711 st032263 62.8 µM -0.417424185122295 0.352942351682463 no 2206 0.33818408394211 3159 3958979 SGTC_1574 spiramycin 23.7 µM -0.418139740686052 0.352698719773771 no 2207 0.337922475257222 3097 6419898 An antibiotic and protein synthesis inhibitor. SGTC_469 w7 172 µM -0.418732237220843 0.352497032633171 no 2208 0.337705916449266 3212 45115570 A P450 inhibitor. SGTC_299 1273-0059 1.44 µM -0.418941659747486 0.352425754653289 no 2209 0.337629384894199 3236 2848077 SGTC_1038 k292-0204 154 µM -0.418972370357408 0.352415302582827 no 2210 0.337618162545928 3077 4454212 SGTC_2184 6075246 200 µM -0.420718227356225 0.351821299861071 no 2211 0.336980424791534 3218 2267320 SGTC_1827 berberine 7.24 µM -0.422974652171447 0.351054119470966 no 2212 0.336156877494162 3131 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_427 1354-0053 47.3 µM -0.423403479591328 0.35090838742928 no 2213 0.336000453298308 3326 6813657 SGTC_2757 clomiphene 4.22 µM -0.423852533955464 0.35075580499951 no 2214 0.335836681321585 3353 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1647 st011722 22.4 µM -0.423884967241979 0.350744785551361 no 2215 0.335824853974911 3263 2854783 SGTC_3071 9117417 49.47 µM -0.424667855519001 0.350478831604058 no 2216 0.335539409876006 3139 45595590 YGL055W OLE1 SGTC_3214 9129694 49.47 µM -0.425928248341417 0.350050819213567 no 2217 0.335080065174784 3285 17158655 SGTC_359 0081-0058 15.9 µM -0.427476910146697 0.349525175334945 no 2218 0.33451599970549 3491 3494159 SGTC_223 busulfan 5 mM -0.427948014294835 0.349365331213632 no 2219 0.334344484542787 3244 2478 A DNA alkylator. SGTC_1257 0669-0121 16 µM -0.430633417559779 0.348454693368367 no 2220 0.333367469401405 3218 4307855 SGTC_58 0957-0393 9 µM -0.431485878503974 0.348165800517407 no 2221 0.333057559186277 3287 6997992 SGTC_1343 1487-0095 224 µM -0.432178554984642 0.347931122322198 no 2222 0.332805822166538 3294 4560101 YGL055W OLE1 SGTC_1748 st037455 53.6035 µM -0.434313127450039 0.347208297604911 no 2223 0.332030536170578 3324 580690 SGTC_1619 st003326 88.7 µM -0.435250160823125 0.346891167704784 no 2224 0.331690428312601 3305 2849032 SGTC_567 1080-0542 68.4 µM -0.436162608292094 0.346582461701901 no 2225 0.331359377482958 3256 5950415 SGTC_866 0495-0101 262 µM -0.437678121855053 0.34606994705766 no 2226 0.330809815628435 3155 635694 SGTC_515 4092-1064 102 µM -0.439124320769318 0.345581135918162 no 2227 0.330285728714966 3371 717353 SGTC_1204 4049-0315 18.3 µM -0.440426468596117 0.34514123378707 no 2228 0.329814128999419 3373 588402 SGTC_2384 9036245 200 µM -0.441973729102766 0.344618797665937 no 2229 0.329254108239696 3198 6462766 SGTC_496 calpeptin 138 µM -0.447112050948251 0.342885961289638 no 2230 0.327397079180867 3232 73364 A calpain inhibitor. SGTC_2582 agaric acid 100 µM -0.447337672005946 0.342809948708547 no 2231 0.327315635375082 3285 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3018 9082602 49.47 µM -0.447403702287403 0.342787704062367 no 2232 0.327291801577316 3301 17332089 SGTC_2416 tofa 880 nM -0.449647550382441 0.34203210852733 no 2233 0.326482297952469 3162 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3337 9144342 33.5465 µM -0.450908129155447 0.34160789716216 no 2234 0.326027882176225 3291 17682949 SGTC_879 0831-1030 162 µM -0.453629801281341 0.340692679609728 no 2235 0.325047650120288 3239 1549252 SGTC_1775 st081588 35.1725 µM -0.455325381462389 0.340122979672754 no 2236 0.324437584404498 3303 1426443 YGL099W LSG1 SGTC_3326 9140064 16.379 µM -0.456122051168637 0.339855431588079 no 2237 0.324151107028938 3165 1868434 SGTC_248 streptozotocin 5.23457 mM -0.456223964117533 0.33982121165856 no 2238 0.324114467284432 3272 5300 DNA alkylating agent. SGTC_2227 7312221 64.1025 µM -0.456400505428846 0.339761936434613 no 2239 0.324051001181874 3263 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1966 st070145 16.1 µM -0.457008053913853 0.339557977230294 no 2240 0.323832628306788 3143 3748532 SGTC_1978 st071761 42 µM -0.457155614585292 0.339508446943805 no 2241 0.323779599303938 3188 5147680 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.457318059131013 0.339453923934341 no 2242 0.323721225607211 3194 6857784 SGTC_698 k064-0052 127 µM -0.458352366989729 0.33910684692211 no 2243 0.323349653613677 3331 5088751 SGTC_2700 st077718 96.8 µM -0.458585552315129 0.339028617047354 no 2244 0.323265906802296 3249 904970 SGTC_796 1234-0020 70.7 µM -0.458841423293396 0.338942784492099 no 2245 0.323174022908232 3251 46495034 SGTC_2055 5235184 200 µM -0.460042282959806 0.338540064891477 no 2246 0.322742935454178 3326 2836034 SGTC_1008 4106-0037 6 µM -0.461664784529826 0.337996236909786 no 2247 0.322160864236812 3149 2905394 SGTC_2981 9013952 38.96 µM -0.462707360162535 0.337646966013421 no 2248 0.321787070945032 3236 2996344 SGTC_626 0214-0009 33 µM -0.462913685204009 0.337577862089719 no 2249 0.321713118853491 3334 3437874 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.463336560107479 0.337436246785823 no 2250 0.321561571912246 3310 1609 A potent and irreversible inhibitor of serine proteases. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.463779088124141 0.337288074562408 no 2251 0.321403013618566 3233 2374 Ca(2+)-ATPase inhibitor. SGTC_2462 5162487 171.77 µM -0.466345853867012 0.336429139342743 no 2252 0.320483980995432 3321 2259986 SGTC_2880 9042983 58.44 µM -0.466547548518129 0.33636168090349 no 2253 0.3204118105854 3325 6464714 SGTC_3262 9137218 49.47 µM -0.466550004032172 0.336360859669021 no 2254 0.320410931994837 3229 17650664 SGTC_1202 1988-0068 29.6 µM -0.467795263463457 0.335944489508745 no 2255 0.319965504070796 3211 2850480 SGTC_520 3584-0023 682 µM -0.470235284497083 0.335129217740468 no 2256 0.319093463849426 3255 1340790 SGTC_2600 tangeritin 87.95 µM -0.471295109053606 0.33477534549856 no 2257 0.318715003936913 3243 68077 A bioactive flavone. SGTC_1296 1068-0102 11.9 µM -0.471577647708961 0.334681031439608 no 2258 0.318614142192779 3283 767053 SGTC_87 0100-0052 35.5 µM -0.471991981723107 0.334542741713371 no 2259 0.31846625593474 3359 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2803 7707263 71.43 µM -0.475594303114147 0.333341364570983 no 2260 0.317181717389532 3205 2199229 SGTC_1730 st033808 45.1 µM -0.476079297583601 0.333179748681209 no 2261 0.317008942657914 3196 1045166 SGTC_1448 4255-0083 152 µM -0.476223377678891 0.333131742485731 no 2262 0.316957623158771 3368 5399660 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.476225722400202 0.333130961268227 no 2263 0.316956788027949 3336 5024745 SGTC_656 4090-1979 187 µM -0.477205886259941 0.332804452365168 no 2264 0.31660776000348 3359 22330961 SGTC_295 k015-0027 31 µM -0.478022706750462 0.33253245267281 no 2265 0.316317021837143 3302 3887424 SGTC_1297 1068-0111 14.1 µM -0.479857897685476 0.331921659216491 no 2266 0.315664220234311 3225 767057 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.480715603089936 0.331636348238286 no 2267 0.315359320052285 3274 2724278 An inhibitor of dopamine biosynthesis. SGTC_402 epigallocatechin gallate 10 µM -0.480717740628942 0.331635637319622 no 2268 0.315358560349217 3242 65064 An antioxidant. SGTC_1641 st009299 47.1 µM -0.481182975595308 0.331480920438546 no 2269 0.315193229697519 3327 4046054 SGTC_1659 st012954 42.1 µM -0.481759481359004 0.331289239627747 no 2270 0.314988408063667 3334 24207262 SGTC_2686 alizarin 95.37 µM -0.48445255681604 0.3303944124805 no 2271 0.31403236339701 3261 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1622 st003707 19.4 µM -0.484882039284054 0.330251797955837 no 2272 0.313880011769652 3345 10140899 SGTC_2910 7948405 25.97 µM -0.485810638010659 0.329943530524312 no 2273 0.313550715582921 3365 2971328 SGTC_278 4092-0821 23.9 µM -0.486116913142117 0.3298418815077 no 2274 0.313442138008556 3327 877900 SGTC_1829 berberine 14.4 µM -0.486165589176749 0.329825727676717 no 2275 0.313424883359535 3379 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1152 3909-8331 15.9 µM -0.486831393907598 0.32960480282646 no 2276 0.313188910335823 3264 16001939 SGTC_1955 wogonin 32.4 µM -0.487583697633509 0.329355247739338 no 2277 0.31292237255887 3449 5281703 A flavanone. SGTC_2771 fluoxetine 41.05 µM -0.487939386401522 0.32923728469074 no 2278 0.31279638767844 3402 3386 A selective serotonin reuptake inhibitor. SGTC_710 3448-4187 58 µM -0.488023751868496 0.329209307645532 no 2279 0.312766508656719 3339 3946412 SGTC_219 mitoxanthrone 164.414 µM -0.489550254779588 0.328703258271471 no 2280 0.312226092369513 3308 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3186 9110464 49.47 µM -0.490401914361683 0.328421061872091 no 2281 0.311924761149773 3383 17018021 SGTC_714 4296-0578 26.1 µM -0.490579706243019 0.328362163082662 no 2282 0.31186187131706 3260 1589775 SGTC_221 trifluoperazine 10.304 µM -0.491524505294094 0.328049242203657 no 2283 0.311527762207889 3339 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_603 3794-0023 45.9 µM -0.491963092522316 0.327904021510066 no 2284 0.311372717394313 3351 3802260 SGTC_1126 isoteolin 1.0172 µM -0.492427228659313 0.327750369647727 no 2285 0.311208677225465 3264 133323 SGTC_1996 st072960 66.8 µM -0.49317935495561 0.32750144081538 no 2286 0.310942931969971 3391 1719405 SGTC_57 miconazole 162.5 nM -0.493730113132329 0.327319206763567 no 2287 0.310748397669014 3312 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2233 sulbentine 40.3845 µM -0.494154113052149 0.327178942325618 no 2288 0.310598671913864 3321 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_453 enantio-paf c16 10 µM -0.494547039493387 0.327048979165569 no 2289 0.31045994704128 3362 13871343 A lipid and platelet activating factor SGTC_2794 7785382 27.27 µM -0.496795428386077 0.326305712589579 no 2290 0.309666659692295 3373 2205081 SGTC_1812 st052057 4.327 µM -0.497206115612462 0.326170023033237 no 2291 0.309521854621847 3275 3645418 SGTC_3187 9109394 49.47 µM -0.499880302884666 0.325287044721708 no 2292 0.308579681190979 3286 17098090 SGTC_1272 0839-0021 27 µM -0.500148872335864 0.325198421008827 no 2293 0.308485127889264 3339 5027250 SGTC_1633 st005664 67.9 µM -0.501302156859133 0.324817967611542 no 2294 0.308079243784579 3246 2063822 SGTC_1347 1493-0251 600 nM -0.502097515203495 0.324555695747313 no 2295 0.307799463990214 3389 3986378 SGTC_2925 9010536 32.5 µM -0.503829132906396 0.323984990447266 no 2296 0.307190726782751 3300 2994177 SGTC_1873 rapamycin 2 nM -0.505292317961058 0.323503077191473 no 2297 0.306676768798015 3316 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2033 5192550 145 µM -0.505429651077903 0.323457860462339 no 2298 0.306628548691187 3289 182073 SGTC_751 0833-0568 350 µM -0.505797434715527 0.32333678107499 no 2299 0.306499429781637 3352 6954252 SGTC_3063 1327-0034 4 µM -0.507833704338746 0.322666752175533 no 2300 0.305784985419666 3346 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2060 5238662 140 µM -0.507954027215867 0.322627178248711 no 2301 0.305742792089776 3332 790130 SGTC_2157 5649910 96.377 µM -0.508379147148635 0.322487373339928 no 2302 0.305593736973579 3277 2858091 SGTC_2111 5486399 200 µM -0.509922707990161 0.321979969156865 no 2303 0.305052806194455 3348 689674 SGTC_3288 9119690 36.221 µM -0.510146902991363 0.321906298635513 no 2304 0.304974273900506 3307 17595618 YKL019W RAM2 SGTC_925 2064-1272 59.6 µM -0.511356673434958 0.321508888677669 no 2305 0.304550663726373 3294 6815817 SGTC_2868 9035608 32.47 µM -0.511683107838316 0.321401689842311 no 2306 0.304436405139652 3341 6462614 SGTC_961 1252-1571 372 µM -0.511780214699245 0.321369803480532 no 2307 0.304402419473529 3444 6813498 SGTC_1588 farnesol 29.9 µM -0.511928543417201 0.321321100264881 no 2308 0.304350510333063 3355 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_725 1497-0963 19 µM -0.512375002928425 0.321174525389467 no 2309 0.304194291084954 3403 3549977 SGTC_1017 4239-0030 168 µM -0.512442987685608 0.32115220809905 no 2310 0.304170505885908 3301 1149593 SGTC_1948 st076329 66.6 µM -0.512514667501065 0.32112867853496 no 2311 0.304145428828356 3322 24208413 SGTC_2102 5377816 72.7585 µM -0.513286654338847 0.320875312228008 no 2312 0.303875408997239 3434 1379702 SGTC_2665 lovastatin 100 µM -0.513306353961978 0.320868847896672 no 2313 0.303868520008366 3366 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_43 0570-0105 72.5 µM -0.514611990166561 0.320440531156945 no 2314 0.303412092397468 3353 1114046 YDL195W SEC31 SGTC_1772 st048439 82.2 µM -0.514885193869718 0.320350936324994 no 2315 0.303316623922268 3360 2927068 YDL195W SEC31 SGTC_3075 9116269 49.47 µM -0.51491521103499 0.320341093089127 no 2316 0.303306135523666 3444 17015205 YNL244C SUI1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.515936383584829 0.320006305278959 no 2317 0.302949420802009 3474 16725076 SGTC_978 1416-0512 87.4 µM -0.516240134121329 0.319906750001604 no 2318 0.302843351287182 3381 6814003 SGTC_255 tunicamycin 200.472 nM -0.516244071368379 0.319905459640549 no 2319 0.302841976511919 3334 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2521 angolensin 13.4 µM -0.516341083484609 0.319873666373592 no 2320 0.302808103508627 3417 821428 A flavenoid. SGTC_94 0334-0113 514.748 µM -0.516623813388399 0.319781016347823 no 2321 0.302709394477511 3345 6795178 SGTC_646 4092-0839 27.3 µM -0.517981058257781 0.319336406529748 no 2322 0.302235742608567 3452 877796 SGTC_893 0958-0369 48.9 µM -0.518361950043651 0.319211679635827 no 2323 0.302102878626098 3390 6819948 SGTC_2094 5332512 191.667 µM -0.519411331614388 0.318868154822161 no 2324 0.301736965461654 3418 755774 SGTC_2127 5253358 187.912 µM -0.520957887554195 0.318362158967807 no 2325 0.301198054080782 3269 20612 SGTC_1851 st056236 18.9 µM -0.523988542788255 0.317371584291709 no 2326 0.300143254367912 3446 5393171 SGTC_345 1362-0200 395 µM -0.524100421242405 0.317335041599376 no 2327 0.300104347794913 3335 1419823 SGTC_2371 9071574 200 µM -0.526762332201138 0.316466111417939 no 2328 0.299179321895369 3403 45596039 SGTC_3 0833-0587 95.581 µM -0.527421634667552 0.316251050875893 no 2329 0.298950411444855 3363 5382644 SGTC_3232 9132874 49.47 µM -0.527566987015447 0.316203646162405 no 2330 0.298899955674274 3345 3784940 SGTC_2490 carminic acid 95.39 µM -0.527721821562412 0.316153152280106 no 2331 0.298846212629168 3395 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_824 1304-0008 100 µM -0.528769919257995 0.315811442001343 no 2332 0.298482533609139 3322 768245 SGTC_3052 9092717 49.47 µM -0.529146137542321 0.315688822282077 no 2333 0.298352038899992 3435 25237534 SGTC_3095 9117207 49.47 µM -0.530052000299729 0.315393660341574 no 2334 0.298037938817878 3378 17015229 SGTC_752 1896-0090 130 µM -0.53244286110265 0.31461519979082 no 2335 0.297209653130291 3406 772567 SGTC_2905 7799065 20.05 µM -0.532475678605751 0.314604520183587 no 2336 0.297198291214599 3419 1296806 SGTC_3004 9076122 71.4286 µM -0.533894403357793 0.314142981311222 no 2337 0.296707297194861 3429 44782551 SGTC_1232 0279-0259 161 µM -0.534008029806403 0.314106028963811 no 2338 0.296667989283047 3358 1560000 SGTC_1441 4106-0040 13 µM -0.5350687940123 0.313761148807941 no 2339 0.296301143829189 3397 2904180 SGTC_158 k038-0087 26.446 µM -0.536482894719173 0.313301643390459 no 2340 0.295812427315443 3334 X158 SGTC_2479 5617353 43.85 µM -0.536889413471268 0.313169600599702 no 2341 0.295672002039084 3468 2731746 SGTC_625 k213-0058 121 µM -0.537187834271701 0.31307268473062 no 2342 0.295568936942441 3426 3655420 SGTC_526 4469-0568 170 µM -0.539748771551636 0.312241519941974 no 2343 0.294685150182651 3392 2901964 SGTC_944 3370-0224 231 µM -0.539765929284088 0.312235954530389 no 2344 0.294679233112544 3370 4580514 SGTC_532 1548-0774 215 µM -0.53987831579852 0.312199501051884 no 2345 0.294640476497334 3542 5932993 SGTC_196 k015-0023 18.111 µM -0.539994467099198 0.312161828366322 no 2346 0.294600424062345 3379 5211998 SGTC_79 0052-0007 94.094 µM -0.540374614167903 0.312038544635861 no 2347 0.294469355574532 3477 2801472 SGTC_2189 6047310 154.431 µM -0.540580104780884 0.31197191169342 no 2348 0.29439851698292 3372 711535 SGTC_1235 benzylparaben 21.5 µM -0.540676946393915 0.311940511702701 no 2349 0.294365135589759 3399 7180 SGTC_253 dyclonine 31.25 µM -0.54105852486589 0.311816801741586 no 2350 0.294233622152404 3446 3180 An oral anasthetic. SGTC_3128 9127691 49.47 µM -0.541145189758302 0.311788707437095 no 2351 0.294203756331094 3408 41316314 SGTC_1270 0831-1170 17.3 µM -0.541389193238805 0.311709614300034 no 2352 0.294119677159974 3442 6764716 SGTC_2917 7979103 53.79 µM -0.54247417651437 0.311358024809741 no 2353 0.293745946152144 3450 2980565 SGTC_418 lividomycin a 100 µM -0.543631143608247 0.310983298401631 no 2354 0.293347662033096 3461 72394 An antibiotic. SGTC_2 0422-0095 29 µM -0.544362452403494 0.310746538128921 no 2355 0.293096039270511 3350 6790840 SGTC_2748 diazoxide 86.69 µM -0.544416408646375 0.310729072967647 no 2356 0.293077478412752 3377 3019 A potassium channel activatior. SGTC_3054 9094397 49.47 µM -0.54548864536665 0.310382087863792 no 2357 0.292708743886828 3363 2598354 SGTC_3296 9122258 64.045 µM -0.546072440832896 0.310193237491855 no 2358 0.292508071442479 3423 4730474 SGTC_3031 9088762 49.47 µM -0.546840716464755 0.309944786414416 no 2359 0.29224408371433 3363 205253 SGTC_67 0335-0847 266 µM -0.548989609572576 0.309250321310797 no 2360 0.291506290215032 3552 4552207 YOR254C SEC63 SGTC_470 aa-861 153 µM -0.549318204789382 0.309144188036783 no 2361 0.29139354809287 3387 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_71 0417-1750 47.813 µM -0.549697116308556 0.309021822825033 no 2362 0.291263567539825 3458 6811472 SGTC_2228 7354201 200 µM -0.5497814610101 0.308994587535439 no 2363 0.291234637895756 3425 753451 SGTC_1076 itraconazole 331 nM -0.550614055567994 0.308725795306456 no 2364 0.290949135774653 3446 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1112 tnp00069 1.16933 µM -0.551069003887185 0.308578964480586 no 2365 0.29079318629699 3446 145826 SGTC_1384 3089-0840 101 µM -0.551382908660632 0.308477672139456 no 2366 0.290685607227522 3442 1069836 SGTC_2770 toltrazuril 17.5 µM -0.551784776279671 0.308348016788399 no 2367 0.290547909373249 3460 68591 Kills coccidiodes. SGTC_304 1310-0298 97 µM -0.55241845844713 0.308143619212576 no 2368 0.290330843499574 3417 1550234 SGTC_2763 lisinopril 49.32 µM -0.553728756889482 0.307721164151016 no 2369 0.289882245834018 3478 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_214 4373-3496 70 µM -0.554076067961633 0.307609229824254 no 2370 0.289763393912417 3516 3779166 SGTC_2006 4011487 200 µM -0.555959467795046 0.307002544015487 no 2371 0.28911928176827 3497 45595294 SGTC_3345 9148410 3.559 µM -0.557421605251243 0.30653192035585 no 2372 0.288619703697469 3462 4903596 SGTC_2706 st078239 82.5 µM -0.557944892565686 0.306363565349978 no 2373 0.288441007556394 3475 15434492 SGTC_2352 9027995 87.8 µM -0.559822873405016 0.305759707268032 no 2374 0.287800130124059 3392 2997347 SGTC_1224 0823-0416 294 µM -0.560023319662833 0.305695285628443 no 2375 0.287731765828156 3481 3598164 SGTC_1733 st037357 54.9 µM -0.561390878557201 0.305255924944113 no 2376 0.287265550414481 3385 1272339 YGL099W LSG1 SGTC_1451 4152-0210 104 µM -0.561922518378981 0.30508519872657 no 2377 0.287084405278066 3489 659563 SGTC_2781 5567276 71.43 µM -0.562787676841753 0.304807459888395 no 2378 0.286789736334293 3476 2853274 SGTC_637 1181-0519 7.26 µM -0.562929254521064 0.304762020395958 no 2379 0.286741529289068 3472 6252091 YGR060W ERG25 SGTC_3339 9145883 14.936 µM -0.564149702929601 0.304370441237905 no 2380 0.286326127312117 3444 2030670 SGTC_372 0155-0182 15.9 µM -0.5644110332762 0.304286622887617 no 2381 0.286237215891448 3442 771486 SGTC_2561 acetosyringone 100 µM -0.566040634213078 0.303764181408501 no 2382 0.285683079023798 3348 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2364 9055074 200 µM -0.566918627115187 0.303482867525467 no 2383 0.285384734073484 3434 6470630 SGTC_1558 st069300 45.6 µM -0.566956272858244 0.303470808218983 no 2384 0.2853719452412 3452 24208000 SGTC_2777 climbazole 1.536 µM -0.567258125312414 0.303374121593209 no 2385 0.285269411234911 3440 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1353 1498-1206 8.11 µM -0.568300958982787 0.303040196599652 no 2386 0.284915313981761 3521 6756808 SGTC_3297 9117502 71.43 µM -0.568589651073224 0.302947783792363 no 2387 0.284817324796199 3461 7453720 SGTC_2197 6588183 93.1375 µM -0.568677329770865 0.302919719588647 no 2388 0.284787567676741 3437 884136 SGTC_850 0388-0143 75.9 µM -0.569461043128191 0.302668920269186 no 2389 0.284521650493834 3389 67273 SGTC_2744 captopril 92.04 µM -0.569799433929098 0.302560659208519 no 2390 0.284406869764996 3439 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2916 7875993 68.79 µM -0.571569948349219 0.301994503352607 no 2391 0.283806679756116 3510 1299250 SGTC_2856 9022925 19.48 µM -0.572118286247972 0.301819258373896 no 2392 0.283620920723243 3455 4944862 SGTC_2511 berberine 10.47 µM -0.57414873486836 0.301170739471056 no 2393 0.28293357844905 3442 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3314 9135860 59.4275 µM -0.574991399572888 0.300901779476664 no 2394 0.28264855678146 3489 25252478 SGTC_3207 9114163 49.47 µM -0.576394432181557 0.300454202899796 no 2395 0.282174303481436 3580 849233 SGTC_863 0466-0191 129 µM -0.576998034698909 0.300261742312601 no 2396 0.281970391572574 3481 765160 YPR165W RHO1 SGTC_2952 9073731 13.78 µM -0.577114639503453 0.30022456892255 no 2397 0.281931007757903 3417 16457353 SGTC_2419 paclitaxel 166.5 µM -0.577217049330511 0.300191922580567 no 2398 0.281896420548756 3426 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2760 etidronate 98.04 µM -0.578466417518025 0.299793776622631 no 2399 0.281474631990555 3431 3305 A chelator and antioxidant. SGTC_1979 st071809 45.3 µM -0.578996953385837 0.299624778955094 no 2400 0.281295614440824 3526 4976333 SGTC_3126 9127922 49.47 µM -0.579950424248423 0.29932116750586 no 2401 0.280974025088016 3525 45595682 SGTC_408 cantharidin 100 µM -0.580592184293272 0.299116891994379 no 2402 0.280757670530043 3430 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1743 st037606 46.3785 µM -0.580928916328644 0.299009733781259 no 2403 0.280644181347765 3472 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1337 1486-1011 40.3 µM -0.582233370138449 0.298594782203156 no 2404 0.280204749427516 3505 X1337 SGTC_3199 9111318 49.47 µM -0.583821439835004 0.298089965166039 no 2405 0.279670226058747 3444 8548020 SGTC_2363 9053361 176 µM -0.585225610555396 0.297643930297823 no 2406 0.279198013268933 3564 6469797 YMR079W SEC14 SGTC_1665 st014639 11.4 µM -0.585981905024661 0.297403819609419 no 2407 0.278943837411255 3548 981133 YIL048W NEO1 SGTC_69 0096-0274 206.684 µM -0.587254117976133 0.297000113255741 no 2408 0.278516525498489 3643 6741392 SGTC_2887 9044784 58.44 µM -0.588908906157667 0.296475381209022 no 2409 0.277961191488586 3502 6465546 SGTC_476 mead acid 10 µM -0.591244881542395 0.295735369324299 no 2410 0.277178177348409 3499 5312531 An omega 9 fatty acid. SGTC_576 1073-0113 22.7 µM -0.59152459223544 0.295646816911633 no 2411 0.277084491294447 3647 5439563 SGTC_1304 1165-0502 251 µM -0.592975457457273 0.295187689378939 no 2412 0.276598788585835 3457 767425 SGTC_1752 st044819 83.042 µM -0.593078693996201 0.295155032601887 no 2413 0.276564244244323 3423 441209 YML126C ERG13 SGTC_2676 harmalol 100 µM -0.594420980333912 0.294730579159687 no 2414 0.276115289700105 3532 5459187 A monoamine oxidase inhibitor SGTC_2319 6033012 152.6 µM -0.596579453357202 0.294048624697324 no 2415 0.275394096253568 3406 847246 SGTC_110 0850-0284 111.64 µM -0.597654012956657 0.293709397270601 no 2416 0.275035408077385 3409 3906265 SGTC_1779 st039427 55 µM -0.600050251450153 0.292953582414765 no 2417 0.274236372982995 3564 1124498 SGTC_2342 7990637 118.86 µM -0.600642958342084 0.292766771785014 no 2418 0.274038909547359 3530 2033102 YER133W GLC7 SGTC_1988 st071872 53.4 µM -0.602935162658271 0.292044831052557 no 2419 0.273275911472977 3550 16414116 SGTC_117 lucigenin 22.078 µM -0.603554497511455 0.291849910876305 no 2420 0.273069936354206 3527 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_933 2914-0560 114 µM -0.605771581162923 0.291152636438125 no 2421 0.272333221746521 3553 463887 SGTC_1884 5633444 25 µM -0.607894240967735 0.290485788191995 no 2422 0.271628809710486 3558 5724239 SGTC_2765 myclobutanil 7.74 µM -0.614069917262397 0.288549733493696 no 2423 0.26958456309525 3548 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_317 4495-0002 170 µM -0.614816821566357 0.288315994119138 no 2424 0.269337849484075 3509 15991618 SGTC_754 3474-0146 171 µM -0.614945457305579 0.288275747324042 no 2425 0.269295370615524 3450 24762078 SGTC_2091 4-phenylthiadiazole 200 µM -0.614997362563529 0.288259508261869 no 2426 0.26927823110006 3503 270010 SGTC_758 0868-0029 16 µM -0.615293901015475 0.288166741612278 no 2427 0.269180322314412 3545 762687 SGTC_2612 dictamnine 15.46 µM -0.616346719186516 0.287837500460197 no 2428 0.268832855232881 3483 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2353 9059630 146.67 µM -0.620368329108743 0.286581486244867 no 2429 0.267507659280133 3544 4779114 SGTC_2143 5623677 140.463 µM -0.621847611826156 0.286120137069635 no 2430 0.267021037857664 3546 5375313 SGTC_1726 st035556 14.5795 µM -0.622774235846514 0.285831327377335 no 2431 0.266716445637898 3597 5919439 SGTC_1597 7-benzyloxygramine 47.5 µM -0.623403329872194 0.285635330718882 no 2432 0.266509755165665 3535 260807 SGTC_2738 aclarubicin 5.55 µM -0.623578856198896 0.285580656231308 no 2433 0.266452099994857 3464 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2281 7943571 200 µM -0.623819263906095 0.285505780003187 no 2434 0.266373143463218 3610 1244024 SGTC_1960 st011366 51.8 µM -0.624917743700515 0.285163771735279 no 2435 0.266012523049456 3564 3972846 SGTC_320 4092-0846 5.34 µM -0.628031111623341 0.284195496724479 no 2436 0.264991779643909 3517 1359356 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.62867491162697 0.283995467607558 no 2437 0.264780953079207 3555 2724 A muscle relaxant with antifungal properties. SGTC_1197 1601-0112 267 µM -0.629901790406902 0.283614462113443 no 2438 0.264379420706108 3536 7350313 SGTC_1959 st077091 55.8 µM -0.632126160648211 0.282924312152263 no 2439 0.263652220998349 3574 821356 YKL052C ASK1 SGTC_2974 9094440 9.66 µM -0.632578538186793 0.282784052810093 no 2440 0.263504452949284 3594 25236134 SGTC_2147 5545932 89.7195 µM -0.634518647339643 0.282182902430394 no 2441 0.262871200613117 3562 797404 SGTC_2815 7968870 71.43 µM -0.634742242201294 0.282113660242775 no 2442 0.262798269209291 3580 2977326 YHR190W ERG9 SGTC_2950 9072895 21.46 µM -0.635253946351762 0.281955228021872 no 2443 0.262631402257782 3544 17332245 SGTC_1101 ebselen 5.29 µM -0.635674769564214 0.281824966195288 no 2444 0.262494212260044 3632 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1424 4048-1941 275 µM -0.636313951082194 0.281627169126452 no 2445 0.262285906807732 3620 X1424 SGTC_2839 9003951 25.97 µM -0.639756345409272 0.280563060233803 no 2446 0.261165508780724 3567 2990634 SGTC_2657 nystatin 74.44 µM -0.640249652090549 0.280410729386002 no 2447 0.261005153702735 3595 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_370 0180-0345 38.7 µM -0.641409485490005 0.280052735965613 no 2448 0.260628335888879 3516 3989527 SGTC_1799 st045822 46.1415 µM -0.643133284629322 0.279521078905537 no 2449 0.260068809291748 3578 3674992 SGTC_596 1155-0152 116 µM -0.643278568628606 0.279476292570024 no 2450 0.260021679987575 3599 280313 SGTC_583 1488-1091 88.9 µM -0.643730010779821 0.279337149867841 no 2451 0.259875262826478 3656 4303273 SGTC_3309 9129340 25.759 µM -0.643905733771624 0.279282997939493 no 2452 0.259818281729285 3589 17158987 SGTC_2439 5492030 7.2 µM -0.645265046565059 0.278864275801855 no 2453 0.259377719893772 3543 5722370 SGTC_1634 st006576 41 µM -0.646167987907733 0.278586303088081 no 2454 0.259085284393723 3597 3915356 SGTC_2396 5342950 42.78 µM -0.646184891563347 0.278581100543191 no 2455 0.259079811434956 3575 1886677 SGTC_1673 st016611 27.3 µM -0.647737608624181 0.278103412915046 no 2456 0.25857733758605 3606 5226799 SGTC_2004 4023728 41.89 µM -0.652298069179712 0.276702718671258 no 2457 0.257104452695193 3584 360084 YDR527W RBA50 SGTC_817 1391-0715 46 µM -0.652345271374513 0.276688239140759 no 2458 0.257089230720649 3536 1353946 SGTC_2807 7945238 51.95 µM -0.65314240842814 0.276443769099446 no 2459 0.256832237214356 3616 17148797 SGTC_2360 9040895 200 µM -0.654602180926997 0.275996353443291 no 2460 0.256361959779748 3552 4914414 SGTC_1411 3909-8223 150 µM -0.655100878882529 0.275843585633368 no 2461 0.256201403134417 3609 X1411 SGTC_693 4161-2696 114 µM -0.655294719825618 0.275784216905027 no 2462 0.256139009869873 3606 805759 SGTC_2253 7938677 135.83 µM -0.656825555489302 0.275315580206104 no 2463 0.255646545058159 3639 2301972 SGTC_2650 prasterone 100 µM -0.657186950653614 0.275205003049462 no 2464 0.255530357606078 3572 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_643 k048-0106 28.4 µM -0.657311606598309 0.275166866770546 no 2465 0.255490287496503 3612 6763920 SGTC_1952 st077036 64.1 µM -0.657826948136728 0.275009234773034 no 2466 0.255324668053334 3621 2937007 SGTC_2852 9023854 51.95 µM -0.659282575680251 0.274564229749604 no 2467 0.254857164655127 3661 19798528 SGTC_378 3970-0959 8.33 µM -0.659607106913589 0.274465064614084 no 2468 0.254752996184631 3613 6615653 SGTC_1361 1608-0041 5.61 µM -0.659731646173498 0.274427014564669 no 2469 0.254713027325463 3602 X1361 SGTC_448 monastrol 171 µM -0.660975626041457 0.274047088639906 no 2470 0.254313972402909 3564 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3182 9108849 49.47 µM -0.662375965669007 0.273619719822799 no 2471 0.253865151436937 3631 17133045 SGTC_312 4092-0653 6.84 µM -0.663771419313199 0.27319417046163 no 2472 0.253418310406455 3610 1148278 SGTC_2459 5811157 9.22 µM -0.664412160976813 0.272998883552181 no 2473 0.253213275783125 3597 2870684 YBR192W RIM2 SGTC_2483 5729050 27.16 µM -0.664498077829834 0.27297270285358 no 2474 0.253185789387795 3660 2865180 SGTC_873 0591-4978 488 µM -0.665536438155494 0.272656390773716 no 2475 0.252853722770576 3681 3305145 SGTC_1813 st051246 8.6015 µM -0.666408333842372 0.272390928813511 no 2476 0.252575068558106 3575 5291959 SGTC_1339 1486-1321 22.7 µM -0.666605631522378 0.272330876338006 no 2477 0.252512035498705 3631 3469382 SGTC_2210 7115885 190.385 µM -0.667199670206998 0.272150105555718 no 2478 0.252322300884462 3632 2927039 SGTC_109 0132-0036 33.701 µM -0.668156156830718 0.271859164326807 no 2479 0.252016959222824 3513 67274 A color developer. SGTC_1657 st012939 43.4 µM -0.669351350561033 0.271495831518895 no 2480 0.251635688679347 3647 24207257 SGTC_2203 7227154 166.4 µM -0.669578122067811 0.271426921444948 no 2481 0.251563382262269 3627 896304 SGTC_1281 0884-0031 11.8 µM -0.670201037686162 0.271237678138886 no 2482 0.251364821234248 3643 1548255 SGTC_127 0180-0333 59.125 µM -0.671844129355046 0.270738818601024 no 2483 0.250841465893466 3610 771601 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.672080130737806 0.270667203793827 no 2484 0.250766342457198 3470 4000243 SGTC_1397 3532-0190 20.1 µM -0.674582120270413 0.269908555335598 no 2485 0.24997064786877 3566 5322280 SGTC_1498 4478-3555 97.6 µM -0.675283386126876 0.269696109983198 no 2486 0.249747868609324 3614 3437919 SGTC_816 0325-0417 81.3 µM -0.67636761314835 0.26936781319728 no 2487 0.249403637253718 3629 68101 SGTC_739 1486-1183 203 µM -0.676416307310841 0.269353073629153 no 2488 0.249388183258176 3630 4346692 SGTC_868 0527-0199 213 µM -0.678381004880418 0.26875870346447 no 2489 0.248765074849748 3601 2849450 SGTC_2994 9053520 71.4286 µM -0.681661194280976 0.267767834543438 no 2490 0.247726605299864 3629 4647384 SGTC_983 1491-0821 12.2 µM -0.682191609027898 0.267607781641602 no 2491 0.247558899895654 3614 46495113 SGTC_536 3852-0578 10.6 µM -0.682506946483117 0.26751265127809 no 2492 0.247459225926816 3661 2869208 SGTC_988 1497-1057 103 µM -0.68277662264806 0.267431309449322 no 2493 0.247374001898871 3649 3533044 SGTC_1185 1319-0113 81.3 µM -0.683094386696969 0.267335478990212 no 2494 0.247273601102863 3666 4672763 SGTC_61 0978-8327 98.565 µM -0.684129436581562 0.267023451497052 no 2495 0.246946717640763 3667 6150059 YHR072W ERG7 SGTC_1476 4112-3294 3.34 µM -0.684503556645469 0.26691071404188 no 2496 0.246828622130945 3682 704369 SGTC_1691 st019933 84.6 µM -0.685541096704635 0.266598187259536 no 2497 0.246501268341295 3631 6176082 SGTC_2017 5132927 60.65 µM -0.685982491569091 0.266465286864595 no 2498 0.246362074611483 3644 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_787 4152-0075 138 µM -0.686579240038032 0.266285664063552 no 2499 0.246173957172148 3670 9566539 SGTC_2957 9076800 11.52 µM -0.687217138725502 0.266093722733355 no 2500 0.245972952858208 3614 16459615 SGTC_760 0568-0725 82.9 µM -0.690418152311773 0.265131608835623 no 2501 0.244965632319722 3663 3916171 SGTC_1182 1222-0449 220 µM -0.691292571774721 0.264869096183759 no 2502 0.244690849488852 3638 658318 SGTC_1100 amiodarone 5.07 µM -0.693831888749554 0.264107508223698 no 2503 0.24389382092138 3702 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1434 4073-0095 163 µM -0.69413365144917 0.26401707824958 no 2504 0.243799198319515 3664 24133745 SGTC_513 4245-1575 41.7 µM -0.6943025524665 0.263966470152358 no 2505 0.243746245308976 3644 719745 SGTC_300 r073-0011 5.04 µM -0.694973859399632 0.263765374210705 no 2506 0.243535841875966 3697 2735780 SGTC_1373 2887-0003 58.5 µM -0.695956845365926 0.263471053076447 no 2507 0.243227927956559 3660 776948 SGTC_2741 miltefosine 3.04 µM -0.697957322785377 0.262872597475226 no 2508 0.242601942002461 3608 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1494 4358-1428 177 µM -0.69835274430862 0.262754386927958 no 2509 0.242478310723211 3695 1564571 SGTC_226 1,3-diallylurea 8.28947 mM -0.699304688266381 0.262469916574373 no 2510 0.24218081887451 3629 74537 YKL182W FAS1 SGTC_1200 1643-0193 18.4 µM -0.69936196677424 0.262452805011518 no 2511 0.242162925090553 3678 5403974 SGTC_1151 3909-8316 15.3 µM -0.69958197266895 0.262387085064066 no 2512 0.242094201997395 3692 800431 SGTC_3224 9130643 49.47 µM -0.702229135158023 0.261596988495109 no 2513 0.24126813935659 3710 17644395 SGTC_3266 9136860 49.47 µM -0.70331014813786 0.261274690888902 no 2514 0.240931243893947 3620 4871271 YPR165W RHO1 SGTC_209 4077-0173 175.592 µM -0.703416261498818 0.261243064818923 no 2515 0.240898187681054 3605 15993494 SGTC_2220 6782180 200 µM -0.70358442891495 0.261192948161616 no 2516 0.240845805571823 3611 833803 SGTC_1712 st032288 53.4 µM -0.703594811366152 0.261189854182246 no 2517 0.240842571767392 3666 2883011 SGTC_1054 3429-0080 167 µM -0.704186935855453 0.261013431747637 no 2518 0.240658182855753 3693 1162877 SGTC_2304 7443016 91.4 µM -0.705271312495456 0.260690502581281 no 2519 0.240320704813424 3640 939854 SGTC_1903 st060211 78.3 µM -0.707229897648244 0.260107754186232 no 2520 0.239711810897387 3714 688960 SGTC_3021 9087658 49.47 µM -0.707396732190921 0.260058146062216 no 2521 0.239659983549451 3661 25237042 SGTC_1624 st003710 6.25 µM -0.707515049591895 0.260022967430059 no 2522 0.239623231815761 3694 24207033 SGTC_2103 5378138 10 µM -0.709581721860418 0.259408891657326 no 2523 0.238981778784927 3729 244142 SGTC_275 trichlorophene 5.69 µM -0.710122111578514 0.259248447879126 no 2524 0.238814207780519 3737 62616 SGTC_960 1222-0186 7.7 µM -0.710968569692989 0.25899723434401 no 2525 0.238551856379343 3700 3126296 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.712868516142009 0.258433823226177 no 2526 0.237963561471115 3545 88881 An O-methylated flavonoid and antioxidant. SGTC_1855 st056195 39.6 µM -0.713841629357424 0.25814550179556 no 2527 0.237662557291631 3648 4028379 SGTC_1237 0330-0133 46.1 µM -0.715577312950758 0.257631654510725 no 2528 0.237126193198864 3646 X1237 YHR072W ERG7 SGTC_2940 9060638 45.86 µM -0.715735855286932 0.257584744706556 no 2529 0.237077233330188 3707 4027022 SGTC_524 r073-0010 27.8 µM -0.716471761472841 0.25736706149586 no 2530 0.236850048987688 3647 2772106 SGTC_355 1311-2252 105 µM -0.717358139123672 0.257104995355183 no 2531 0.236576571028628 3701 5338538 SGTC_291 SEC14.278 35.5 µM -0.717434504750474 0.25708242361252 no 2532 0.236553017741082 3686 1068044 SGTC_1975 st070967 30.8 µM -0.718627479829604 0.256729944283246 no 2533 0.236185238555918 3699 261391 SGTC_56 0957-0365 83.25 µM -0.719459723316358 0.256484196656515 no 2534 0.235928854983533 3649 6752360 SGTC_3068 9116768 49.47 µM -0.721779393097738 0.255799884223817 no 2535 0.235215060413356 3672 41904888 SGTC_491 tetrandrine 80.3 µM -0.721939090592307 0.255752807874821 no 2536 0.235165963191567 3684 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1618 st003135 44.5 µM -0.723044708417596 0.255427012953187 no 2537 0.234826208539473 3646 1270615 SGTC_2324 6149169 200 µM -0.724832949298895 0.25490052736008 no 2538 0.2342772596404 3661 2888231 SGTC_1774 st048371 48.465 µM -0.726861576667451 0.254303956589097 no 2539 0.233655378531466 3706 4242727 SGTC_1285 0929-0069 65.5 µM -0.727659816742394 0.254069414112753 no 2540 0.233410927064083 3735 1206237 SGTC_2568 diosmetin 100 µM -0.728449626416736 0.253837460428655 no 2541 0.233169197012634 3706 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3118 9124250 49.47 µM -0.729025707414123 0.253668345362409 no 2542 0.232992968690702 3673 1504786 SGTC_2486 5283202 22.39 µM -0.729792356064032 0.253443378820281 no 2543 0.232758558788806 3748 1377751 SGTC_3056 9094900 49.47 µM -0.729798978282219 0.253441436043381 no 2544 0.232756534555537 3698 25236784 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.730978936955689 0.253095393555788 no 2545 0.232396009261009 3719 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1122 capsaicin 818.572 nM -0.731640427319764 0.252901509293075 no 2546 0.232194033044708 3802 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3320 9137005 35.139 µM -0.731800498754966 0.252854603757611 no 2547 0.23214517230359 3746 4908713 SGTC_235 0330-0087 5 mM -0.731924980599444 0.252818130161673 no 2548 0.232107179004311 3754 46494818 YHR062C RPP1 SGTC_2330 7979373 200 µM -0.732693599069283 0.252592983748525 no 2549 0.23187266443488 3693 1863007 SGTC_1458 k015-0034 6.33 µM -0.736144709769646 0.251583375567168 no 2550 0.230821318051781 3765 3598957 SGTC_1479 0549-0158 134 µM -0.736751746205328 0.251406010292973 no 2551 0.230636666179917 3780 5440202 SGTC_3129 9127257 49.47 µM -0.739054124424577 0.250733897397747 no 2552 0.229937066090272 3728 837894 SGTC_1125 tnp00248 1.32998 µM -0.740204745398735 0.250398363728125 no 2553 0.229587884310878 3847 24207736 SGTC_165 k038-0023 64.381 µM -0.740440191661346 0.250329734365437 no 2554 0.229516469485208 3746 46368543 SGTC_1210 3013-0140 750 nM -0.740739639367254 0.250242463866651 no 2555 0.229425659926581 3773 905973 SGTC_1216 1165-0504 9.65 µM -0.740903388226251 0.250194748018996 no 2556 0.229376010486397 3720 6304004 SGTC_3211 9128781 49.47 µM -0.742211197973663 0.249813830038285 no 2557 0.22897969249657 3785 17194361 SGTC_2345 9052315 157.45 µM -0.74335756183126 0.24948018884262 no 2558 0.228632615213169 3771 6469265 SGTC_401 neomycin 50 µM -0.743532774313444 0.249429215342872 no 2559 0.228579593287039 3743 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2677 mitomycin C 100 µM -0.74386450341288 0.249332722580121 no 2560 0.228479226002565 3757 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_37 0566-0070 1.56 µM -0.744967321847525 0.249012079441116 no 2561 0.228145737525262 3762 1626686 SGTC_458 nppb 133 µM -0.746568360455162 0.24854697014627 no 2562 0.227662076446783 3761 4549 A chloride channel blocker. SGTC_989 1501-0895 10.3 µM -0.748198932281971 0.248073757461727 no 2563 0.227170087472258 3721 2830112 SGTC_2372 9071633 200 µM -0.748985104959282 0.247845772003385 no 2564 0.22693309155604 3805 21321366 SGTC_3148 9097893 49.47 µM -0.74909228018327 0.247814700483344 no 2565 0.226900793821571 3729 17174100 SGTC_1365 1672-3266 55.4 µM -0.750588281569493 0.247381207011068 no 2566 0.226450237861189 3757 6415873 SGTC_2708 st078559 56 µM -0.751176834108468 0.247210774422398 no 2567 0.226273120007427 3702 17250902 SGTC_114 0364-0001 490.298 µM -0.754821010641 0.246156896064037 no 2568 0.225178192714847 3811 4003655 SGTC_454 lyso-paf C-16 6.67 µM -0.75601473857224 0.245812200317032 no 2569 0.22482017954845 3696 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_192 3455-0609 60.9 µM -0.756713919924418 0.245610428102959 no 2570 0.224610636727889 3823 3769639 SGTC_182 3448-4371 550.524 µM -0.757077539482701 0.245505528663411 no 2571 0.224501704705145 3748 3491403 SGTC_761 k216-0224 480 µM -0.757460666175255 0.245395027720176 no 2572 0.224386961235079 3782 1340404 SGTC_2043 5101342 149 µM -0.759751596155215 0.244734838553227 no 2573 0.223701540499842 3788 678451 SGTC_2565 isoliquiritigenin 100 µM -0.760209279898826 0.24460306015079 no 2574 0.223564749425163 3812 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_746 1095-0025 46.6 µM -0.760562138597177 0.244501489550707 no 2575 0.223459320614993 3764 6749286 SGTC_3030 9087619 49.47 µM -0.760646132233549 0.244477315277667 no 2576 0.223434228762796 3786 25236973 SGTC_1750 st081859 2.357 µM -0.761632672097843 0.24419347489073 no 2577 0.223139634629574 3761 5291695 SGTC_283 0987-0079 11.7 µM -0.761973897259451 0.244095341333145 no 2578 0.223037791681713 3799 411556 SGTC_1016 4226-1401 38 µM -0.763868113895965 0.243550967120049 no 2579 0.222472920435957 3766 2901613 SGTC_2593 nobiletin 86.24 µM -0.76547133769983 0.24309073346498 no 2580 0.221995463826261 3792 72344 An anti-infammatory. SGTC_970 1315-0089 19.5 µM -0.767198480078817 0.242595453519914 no 2581 0.22148175822719 3737 6811083 YLR033W RSC58 SGTC_1093 fluphenazine 7.97 µM -0.768709383591287 0.242162631299157 no 2582 0.221032926560382 3808 6602611 An atypical antipsychotic. SGTC_3086 9117350 49.47 µM -0.771423893675035 0.241386069795723 no 2583 0.220227858520065 3701 2679265 SGTC_1217 1183-1422 255 µM -0.774532105930785 0.240498542786828 no 2584 0.219308094798022 3832 2849664 SGTC_2012 4023501 200 µM -0.774890907537971 0.240396204173052 no 2585 0.219202062672959 3811 3477460 SGTC_1407 3909-7909 12.3 µM -0.776647292002555 0.239895584657942 no 2586 0.218683445876246 3778 4411780 SGTC_389 tpck 16.7 µM -0.776995186405204 0.239796492373896 no 2587 0.218580805145579 3822 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2064 5220758 200 µM -0.779780558068804 0.239003928488312 no 2588 0.217760025976781 3857 788518 SGTC_1715 st032160 10.2275 µM -0.779809736870879 0.238995633389836 no 2589 0.217751437136489 3714 5289825 SGTC_3261 9137475 49.47 µM -0.781010973550816 0.238654276369211 no 2590 0.217398020316418 3704 17027690 SGTC_1145 3546-0597 10.2 µM -0.781239368173072 0.238589403366676 no 2591 0.217330861639478 3767 875334 SGTC_916 4466-0038 42 nM -0.783143306902909 0.238048986091431 no 2592 0.21677148120792 3891 5722064 YGL116W CDC20 SGTC_2617 dihydrotanshinone i 20.83 µM -0.783327823703469 0.237996648207049 no 2593 0.216717314145995 3822 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1945 st075991 56.6 µM -0.785711380061972 0.237321123766008 no 2594 0.216018297334631 3814 1084980 SGTC_280 3448-3607 3.04 µM -0.786109665873444 0.237208348222565 no 2595 0.215901621008704 3794 626179 SGTC_1644 st010134 20.9 µM -0.786531453484578 0.23708895019296 no 2596 0.215778099741062 3792 3818134 SGTC_948 3448-0295 75.3 µM -0.787291216105096 0.236873962827826 no 2597 0.215555705253419 3813 678569 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.788310921000389 0.236585589046533 no 2598 0.215257430594983 3861 65057 A dermal irritant. YDR527W RBA50 SGTC_1383 3049-0032 20.7 µM -0.788775566202572 0.236454250910156 no 2599 0.215121596350999 3863 712864 SGTC_377 3970-0964 33.1 µM -0.789184255061826 0.236338762757304 no 2600 0.215002161511596 3794 16481235 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.789684657193169 0.236197400377553 no 2601 0.214855976924189 3806 77254 SGTC_265 mycophenolic acid 32.932 µM -0.790424768385873 0.235988406176691 no 2602 0.214639871001795 3885 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2831 7999036 19.48 µM -0.790653946697422 0.235923710978607 no 2603 0.214572978586852 3886 2988270 SGTC_3033 9090887 49.47 µM -0.792223084504078 0.235481018668556 no 2604 0.214115305316403 3860 19325384 SGTC_2785 7756463 72.73 µM -0.792603915398849 0.235373646085571 no 2605 0.214004313406162 3792 2201551 SGTC_2386 9075165 157.42 µM -0.792938090332249 0.235279450086015 no 2606 0.213906946815304 3792 16452277 SGTC_1742 st038235 28.8875 µM -0.79293879344564 0.235279251916945 no 2607 0.213906741980472 3865 564103 YBR002C RER2 SGTC_2823 7987624 58.44 µM -0.79310549023224 0.235232271843909 no 2608 0.21385818218569 3801 2239440 SGTC_1632 st005650 90 µM -0.794047892822451 0.234966772427891 no 2609 0.213583775288287 3869 2759605 SGTC_2252 omeprazole 400 µM -0.79466971798506 0.234791678753147 no 2610 0.213402825881955 3769 4594 A proton pump inhibitor. SGTC_2435 5706476 10.6 µM -0.794721878485903 0.234776994666704 no 2611 0.213387651383578 3833 5725375 SGTC_108 0509-0257 621.132 µM -0.79573350968127 0.234492303351826 no 2612 0.213093472726365 3795 536624 SGTC_2458 5808907 16.39 µM -0.797156893230995 0.234092061081897 no 2613 0.212679958857438 3906 2731747 SGTC_3139 9095020 49.47 µM -0.800194284387637 0.233239241239509 no 2614 0.21179912041152 3587 25236292 SGTC_897 1000-0139 31.4 µM -0.800244684742491 0.233225104699755 no 2615 0.211784522418267 3796 6151020 SGTC_1467 k284-1082 293 µM -0.801838399862935 0.232778336990823 no 2616 0.211323221410087 3793 3334705 SGTC_181 1447-1644 8.07 µM -0.803862664551742 0.232211559183053 no 2617 0.210738147188005 3833 534600 SGTC_111 0083-0039 52.457 µM -0.804302664037938 0.232088464554741 no 2618 0.210611099748311 3727 759313 SGTC_1834 st055981 52.8 µM -0.805017557445277 0.231888542845861 no 2619 0.210404774053441 3899 471719 YDL150W RPC53 SGTC_849 0386-0493 241 µM -0.80807911832743 0.231033455602362 no 2620 0.209522518835642 3801 726119 SGTC_2673 kobusone 100 µM -0.808324922162308 0.230964879538209 no 2621 0.209451779625944 3878 6710676 An epoxy ketone and protein crosslinker. SGTC_2174 5790901 200 µM -0.808946539073248 0.23079150724349 no 2622 0.209272948917938 3891 786020 SGTC_64 000l-0018 272.079 µM -0.809341245219856 0.230681459319775 no 2623 0.209159444007375 3770 6811119 SGTC_68 0986-0284 82.829 µM -0.809738253370027 0.230570799154025 no 2624 0.2090453136853 3941 423278 YIL048W NEO1 SGTC_430 0958-0115 16.4 µM -0.811456964415155 0.230092076162247 no 2625 0.208551648719943 3821 6833180 SGTC_204 PMA1.184 62.41 µM -0.814211341615054 0.229326043857753 no 2626 0.207761944623624 3883 2252213 YGL008C PMA1 SGTC_1386 3228-0095 33.8 µM -0.816343387783532 0.228734073830696 no 2627 0.20715188283025 3873 870181 SGTC_3342 9147791 14.508 µM -0.819323725773896 0.227908012349505 no 2628 0.206300869771538 3788 1838168 SGTC_2928 9011484 9.79 µM -0.819846895843176 0.227763178464313 no 2629 0.206151696576504 3891 2994751 SGTC_2655 perillic acid 100 µM -0.821147908034222 0.227403232215445 no 2630 0.205781012075412 3899 5702197 An apoptosis inducer. SGTC_2667 digitoxin 100 µM -0.821936952011514 0.227185086525783 no 2631 0.205556390402443 3823 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3178 9107506 49.47 µM -0.822467609934482 0.227038442764978 no 2632 0.205405406870882 3908 8897194 SGTC_2175 5807670 165.306 µM -0.823147108301629 0.226850745894305 no 2633 0.205212171242626 3847 241186 SGTC_619 1652-1634 108 µM -0.823246666489009 0.226823252431466 no 2634 0.205183867977316 3829 5400454 SGTC_2409 alverine citrate 63.97 µM -0.823549126123922 0.22673973830865 no 2635 0.205097896356781 4046 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2879 9041815 71.43 µM -0.826014790020507 0.226059575208098 no 2636 0.204397851001587 3874 4942971 SGTC_789 1309-1135 70.6 µM -0.826281672179291 0.225986023945909 no 2637 0.204322163864676 3858 3092424 SGTC_276 colchicine 750 µM -0.827839240260622 0.225557036689035 no 2638 0.203880774280027 3953 2833 A microtubule depolymerizer. SGTC_1825 st052143 62.6 µM -0.828892003650225 0.225267344558075 no 2639 0.203582760288708 3869 674173 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.829211413641381 0.225179493213626 no 2640 0.203492393789569 3902 61125 An anti-inflammatory. SGTC_212 3807-4682 38.772 µM -0.829340724982238 0.225143932610071 no 2641 0.203455816225145 3957 3125501 YBL034C STU1 SGTC_2805 7950783 58.44 µM -0.829730837194404 0.225036671076536 no 2642 0.203345491167241 3905 1178958 YDL195W SEC31 SGTC_2297 7971671 152.32 µM -0.831291458292543 0.224607867333902 no 2643 0.202904499397353 3857 909016 SGTC_2812 7970281 58.44 µM -0.831668127321089 0.22450444142395 no 2644 0.202798147962267 3921 2233435 SGTC_962 1254-0300 21.5 µM -0.831887235212053 0.224444291138679 no 2645 0.202736298792714 3842 7340576 SGTC_193 1273-0060 1.558 µM -0.834898382069281 0.223618587340775 no 2646 0.201887462906207 3737 2847393 YHR072W ERG7 SGTC_3343 9148379 18.9835 µM -0.834898388742918 0.223618585512675 no 2647 0.201887461027284 3939 1955036 SGTC_1828 st055811 49 µM -0.83576430903401 0.223381456759198 no 2648 0.201643754416292 3924 5877589 SGTC_1287 0971-0001 34.6 µM -0.836076151539914 0.223296095010352 no 2649 0.20155603191642 3872 4665869 SGTC_2555 cholic acid 100 µM -0.836173632863686 0.223269414913009 no 2650 0.201528614735504 3901 6708657 Influences liver metabolism. SGTC_1627 st003713 25.6 µM -0.838051146833263 0.222755903886132 no 2651 0.201000989278448 3956 16195070 YER133W GLC7 SGTC_2217 6934799 96.0675 µM -0.839269891554301 0.222422930665839 no 2652 0.200658937403718 3813 675606 SGTC_1758 st042942 75.2445 µM -0.842620423865261 0.221508996239528 no 2653 0.199720382400697 3819 669317 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.842800848063037 0.221459842394349 no 2654 0.199669916817097 3910 1377 SGTC_2058 5236698 133 µM -0.843729077153913 0.221207058997785 no 2655 0.199410407624737 3903 766665 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.84464785839254 0.220957011149835 no 2656 0.199153739880807 3882 688751 SGTC_2259 7964009 200 µM -0.844921049673009 0.220882692904102 no 2657 0.199077460452204 3941 313134 SGTC_2258 7960471 200 µM -0.845119461614483 0.220828726407678 no 2658 0.19902207166191 3933 2974708 SGTC_1060 3448-7350 82 µM -0.846306588419994 0.220505994958992 no 2659 0.198690866698942 3839 570178 SGTC_455 paf C-16 10 µM -0.850195728835151 0.21945059116486 no 2660 0.197608137990891 3879 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_545 4218-0007 221 µM -0.85145446227858 0.219109628812991 no 2661 0.19725847455933 3892 2840508 SGTC_1020 4335-0961 93.3 µM -0.854886946723065 0.21818139601226 no 2662 0.196306868816331 3847 669075 SGTC_399 oxolinic acid 75 µM -0.856954850807418 0.217623276731975 no 2663 0.19573491858447 3877 4628 A DNA gyrase inhibitor. SGTC_799 1310-0557 151 µM -0.857732475113574 0.217413612298226 no 2664 0.195520101715596 4001 5354492 SGTC_1640 st009078 66.4 µM -0.859392252930643 0.216966490409381 no 2665 0.195062071205687 3875 690618 SGTC_2387 9077560 195.08 µM -0.85965911679466 0.216894650489937 no 2666 0.194988488654576 3892 5303272 SGTC_465 cgp-37157 41 µM -0.860148405689371 0.216762969337127 no 2667 0.194853620546098 3864 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1740 st038286 13.222 µM -0.860577222470943 0.216647600921488 no 2668 0.194735467696242 3968 716786 SGTC_3188 9110789 49.47 µM -0.860627757882103 0.216634007267461 no 2669 0.194721546432382 3895 849217 SGTC_997 3996-0078 137 µM -0.862332595049722 0.216175707755598 no 2670 0.19425226048872 3950 735687 SGTC_677 0929-0063 136 µM -0.862419915278168 0.216152249190825 no 2671 0.194228242640931 3888 1539583 SGTC_1254 0550-0035 264 µM -0.863240369435378 0.215931906328868 no 2672 0.194002661128111 4012 15121435 SGTC_1011 4112-3381 17.4 µM -0.864159935602081 0.215685100486245 no 2673 0.193750018871647 4013 2877139 SGTC_1242 0402-0103 60.1 µM -0.864517153508283 0.215589269543936 no 2674 0.193651930690398 3860 432868 SGTC_2540 epiandrosterone 100 µM -0.864669462182136 0.21554841716494 no 2675 0.193610117582216 3969 441302 A steroid. SGTC_1652 st011932 78 µM -0.864819587348483 0.215508154842151 no 2676 0.193568909298036 3830 1551076 SGTC_1171 0368-0077 21.4 µM -0.865407049990465 0.215350644177838 no 2677 0.19340770643479 3873 3239779 SGTC_2584 androsterone 48.74 µM -0.866460335085197 0.215068404358837 no 2678 0.193118884574979 3911 2754130 A steroid. SGTC_1587 estradiol valerate 56.1 µM -0.867951559282561 0.214669181243203 no 2679 0.192710425781287 3973 13791 A steroid. SGTC_2391 6285546 200 µM -0.869357202864589 0.214293263958282 no 2680 0.192325891950276 3916 846083 SGTC_1123 mangostin 811.285 nM -0.869713107978445 0.214198143514862 no 2681 0.192228603533709 3952 5281650 An antioxidant. SGTC_2026 5148700 152 µM -0.869836947803531 0.214165051412664 no 2682 0.192194758368324 3906 79838 SGTC_1616 st002734 56.1 µM -0.870143631352034 0.214083113172071 no 2683 0.192110958088792 3876 4026101 SGTC_795 0685-0265 78 µM -0.870555329777599 0.213973146249787 no 2684 0.191998497992347 3968 302754 SGTC_2713 st079149 53.4 µM -0.871038239760668 0.213844200242169 no 2685 0.191866637009141 3969 3103253 SGTC_2359 9039622 200 µM -0.871155896326148 0.213812790592747 no 2686 0.191834518697151 3886 6463596 SGTC_1688 st021091 57.6 µM -0.871420408520435 0.213742186109256 no 2687 0.191762323227463 3940 3656366 SGTC_1976 st070609 63.5 µM -0.87278939967007 0.213376987469695 no 2688 0.191388939247643 3833 682556 SGTC_647 0140-0236 81 µM -0.873328973075703 0.213233148278732 no 2689 0.191241896384506 3937 990837 SGTC_328 k915-0120 63.5 µM -0.873859457513919 0.213091787158637 no 2690 0.19109739795183 3927 6624543 SGTC_2464 5717415 7.67 µM -0.8762696835096 0.212450209727629 no 2691 0.190441721007299 3927 5285744 SGTC_1174 0739-0097 51.1 µM -0.877499079103366 0.212123392336166 no 2692 0.190107809408541 3957 728447 SGTC_2374 9071832 200 µM -0.877811637909657 0.212040349898667 no 2693 0.190022973862218 3851 17381698 SGTC_1413 3910-0535 34.4 µM -0.880851097135826 0.211233800611508 no 2694 0.18919920956247 3939 2876951 SGTC_3260 9137109 49.47 µM -0.883037955925877 0.210654610451134 no 2695 0.188607882186732 3860 17478346 SGTC_3218 9131285 49.47 µM -0.883902108919068 0.210425996375103 no 2696 0.188374529347532 3895 17156417 SGTC_2782 7736369 71.43 µM -0.884601043474108 0.210241197877338 no 2697 0.188185921845167 3985 2950836 YOL077C BRX1 SGTC_217 ketoconazole 989 nM -0.887469961224431 0.209483654373686 no 2698 0.187412965877131 3835 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2232 chlorophetanol 41.5365 µM -0.890293963794982 0.208739541476749 no 2699 0.186654030725686 4018 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_82 0054-0107 293.755 µM -0.890548370622537 0.208672582911868 no 2700 0.186585753845343 3920 3104697 SGTC_924 2046-0044 21.3 µM -0.891407628151659 0.2084465243712 no 2701 0.186355263438912 3959 3623589 SGTC_623 k072-0108 16.9 µM -0.891423722259186 0.208442291616763 no 2702 0.186350947979762 3933 5382803 SGTC_3324 9138759 60.749 µM -0.891626481905048 0.208388970119628 no 2703 0.186296585498696 4001 45595710 SGTC_1777 st045864 34.765 µM -0.891759551946784 0.208353979887015 no 2704 0.186260913042081 3923 4691462 SGTC_2911 7942208 15.64 µM -0.892956670296545 0.208039358283197 no 2705 0.18594018853282 3997 1243384 SGTC_2546 rhodinyl acetate 100 µM -0.894670733108456 0.207589364090274 no 2706 0.185481564065878 3870 6708682 SGTC_2849 9019321 12.99 µM -0.896204144312421 0.20718728434914 no 2707 0.185071871343226 3983 16489627 SGTC_3219 9131112 49.47 µM -0.896320313655745 0.207156842064917 no 2708 0.185040856451794 3902 17612988 YMR079W SEC14 SGTC_2306 7482397 179.52 µM -0.897591496383207 0.206823900361016 no 2709 0.184701687104086 3980 891448 SGTC_1561 5-methoxyflavone 52.9 µM -0.898581962493408 0.206564702216908 no 2710 0.184437684960488 3894 94525 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.899163053568415 0.206412724287843 no 2711 0.184282908316457 3988 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3312 9133330 71.43 µM -0.900001300613495 0.206193606824897 no 2712 0.184059779272895 4020 17617324 SGTC_608 k048-0125 159 µM -0.901655557334011 0.205761589535037 no 2713 0.183619934185184 4016 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_800 3448-7362 155 µM -0.902493379445371 0.205542993227225 no 2714 0.183397418390057 4048 15991913 SGTC_216 k038-0035 28.382 µM -0.905490924385158 0.204762033156963 no 2715 0.182602682876296 3897 4444231 YPR107C YTH1 SGTC_1006 4099-6547 255 µM -0.906315175724032 0.20454759805532 no 2716 0.182384527662361 4016 3146833 SGTC_1416 3966-0321 25.3 µM -0.906383738694919 0.204529766911902 no 2717 0.182366388388694 4004 582530 YLR208W SEC13 SGTC_2213 7173844 200 µM -0.907619528590327 0.204208534163913 no 2718 0.182039636507482 3934 892728 SGTC_1168 k815-0004 80.5 µM -0.908752236526121 0.203914360742558 no 2719 0.181740461979999 3960 642433 SGTC_1212 0520-0165 585 µM -0.909471648838636 0.203727654742476 no 2720 0.181550608266439 4120 5403258 SGTC_2223 6903751 107.57 µM -0.910739056881987 0.203398977796421 no 2721 0.181216439965243 3945 5598863 SGTC_2845 9003024 42.97 µM -0.91311702563796 0.202783153437067 no 2722 0.180590498419531 4069 2990173 SGTC_2100 5377183 190 µM -0.913614676376829 0.202654417551314 no 2723 0.18045967592777 4017 2844202 SGTC_3048 9093155 49.47 µM -0.914276222298288 0.202483359718842 no 2724 0.180285860717846 3917 25236002 SGTC_2265 7929201 200 µM -0.915320693382852 0.202213463631673 no 2725 0.180011649343763 3953 1265108 SGTC_2980 9014342 25.29 µM -0.91590200787326 0.202063342588522 no 2726 0.179859146797334 4051 2996599 SGTC_78 0336-0123 156.75 µM -0.915922974077171 0.202057929436278 no 2727 0.179853648021867 3811 6765896 SGTC_2963 9082507 9 µM -0.917447406872782 0.201664576865869 no 2728 0.179454120255868 4047 16459611 SGTC_3065 9113888 49.47 µM -0.919904596210787 0.201031509543262 no 2729 0.178811308411545 4065 16648368 SGTC_1751 st044839 27.194 µM -0.920315914298451 0.200925654639133 no 2730 0.178703847531382 3957 5291326 SGTC_282 k297-0036 65.7 µM -0.92045112064326 0.200890865869649 no 2731 0.178668532430883 4003 5061378 SGTC_2828 7998861 71.43 µM -0.921813260866034 0.20054058707039 no 2732 0.178312994609215 3946 2988188 SGTC_968 1309-0633 340 µM -0.922077897250915 0.200472577534964 no 2733 0.178243972533439 4045 3761976 SGTC_2640 pentamidine 10.38 µM -0.922102829217192 0.200466170923598 no 2734 0.178237470682384 3995 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3302 9125395 16.351 µM -0.92377352736844 0.200037142334042 no 2735 0.177802120431404 3948 17599668 SGTC_1094 duloxetine 25.4 µM -0.925710361330483 0.199540462651356 no 2736 0.177298260884258 4000 60834 A selective serotonin reuptake inhibitor. SGTC_2705 st078069 42.8 µM -0.927733229874334 0.199022513559051 no 2737 0.176772983405591 4062 1530061 SGTC_1905 st060207 84.5 µM -0.928172884444969 0.198910048659494 no 2738 0.176658948752193 3956 1948547 SGTC_3210 9128157 49.47 µM -0.928761591881106 0.19875951560796 no 2739 0.176506326625544 4057 17590849 SGTC_2025 5147754 141 µM -0.931133241176645 0.198153778674958 no 2740 0.175892322753894 3997 315777 YLR208W SEC13 SGTC_2408 sulbentine 18.36 µM -0.932532867735605 0.197796827130021 no 2741 0.175530604439539 4002 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2722 naftopidil 47.16 µM -0.935681089529837 0.19699534641982 no 2742 0.174718704948448 3919 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3341 9147222 25.867 µM -0.935755995888186 0.196976300580382 no 2743 0.174699416321416 4026 1939759 SGTC_2603 homopterocarpin 100 µM -0.936969439049465 0.196667923415712 no 2744 0.174387139177499 4047 101795 A weak amylase inhibitor. SGTC_1529 apigenin 74 µM -0.937136234900648 0.196625557792138 no 2745 0.174344242341356 4039 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2218 6965428 192.983 µM -0.93792453758427 0.196425406201288 no 2746 0.174141596063922 3910 675684 SGTC_344 k064-0035 6.43 µM -0.939845395948457 0.195938213798554 no 2747 0.173648434721062 3980 5088750 SGTC_1129 3453-1384 223 µM -0.941920751620983 0.195412660620243 no 2748 0.173116607431284 4143 1084452 SGTC_718 1130-0073 349 µM -0.944831602762337 0.194676974906075 no 2749 0.172372427441047 4068 6740020 SGTC_2242 6630449 61.2675 µM -0.9456277016655 0.194476063469279 no 2750 0.172169254946593 4093 691249 YDR170C SEC7 SGTC_2397 5161689 200 µM -0.946452303428932 0.194268091887841 no 2751 0.171958969436458 4076 2259942 SGTC_2415 st077333 57.7 µM -0.947472761423591 0.194010911287766 no 2752 0.171698964852029 4068 2766255 SGTC_1181 1222-0449 220 µM -0.948255664945285 0.193813740978866 no 2753 0.171499657592227 4076 658318 SGTC_3308 9128332 17.569 µM -0.949117781714896 0.193596762579325 no 2754 0.171280355775574 4049 17332805 YDL196W YDL196W SGTC_843 0310-0051 143 µM -0.949244988341596 0.193564759636591 no 2755 0.171248012647886 4054 2065037 SGTC_1699 st031318 29.054 µM -0.950325263101585 0.193293111637335 no 2756 0.170973503039196 4072 5340658 SGTC_3160 9100216 49.47 µM -0.953195018165321 0.192572608163649 no 2757 0.17024563503903 3947 17191039 SGTC_2586 curcumin 80 µM -0.954500213101178 0.192245459371237 no 2758 0.169915250743705 3993 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2078 5212016 200 µM -0.954644810587973 0.192209236753632 no 2759 0.169878674057237 3883 1899708 SGTC_159 3970-0959 50 µM -0.957589067605802 0.191472589350993 no 2760 0.169135007013009 4120 6615653 SGTC_2800 7887935 81.82 µM -0.957776486051206 0.191425756252977 no 2761 0.16908773931669 4065 2961002 SGTC_3117 9124945 49.47 µM -0.958358797088057 0.191280290126719 no 2762 0.168940932229147 3942 17592065 SGTC_2946 9065502 71.43 µM -0.958593988499468 0.191221556576743 no 2763 0.168881661079755 3847 16489101 SGTC_3271 9137798 49.47 µM -0.960582615203511 0.190725385668683 no 2764 0.168381036649256 3969 6498326 SGTC_3064 1327-0027 10 µM -0.963945040477003 0.189888245495731 no 2765 0.167536740437437 3938 16000455 YPR107C YTH1 SGTC_2691 st077356 60.2 µM -0.965541895381724 0.189491470308756 no 2766 0.167136731148507 4112 2839272 SGTC_3042 9091578 49.47 µM -0.965637899834467 0.189467632071923 no 2767 0.167112701843806 4032 25236497 SGTC_3313 9133968 57.047 µM -0.966068749511952 0.189360673337355 no 2768 0.167004890336777 4042 1494643 SGTC_620 0109-0052 432 µM -0.966917154946009 0.189150164768302 no 2769 0.166792725017392 4043 493037 SGTC_2129 girgensonine 121.053 µM -0.967381736756635 0.18903495260497 no 2770 0.166676618257718 4075 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_876 0720-0963 56.8 µM -0.967887780922918 0.188909507341569 no 2771 0.166550208724047 4095 765861 SGTC_1057 3448-5381 134 µM -0.969309376387951 0.188557377011364 no 2772 0.16619542621715 4058 5497911 SGTC_1974 st069448 26.9 µM -0.970141360935172 0.188351481641856 no 2773 0.165988017424954 4028 6323587 YNR016C ACC1 SGTC_1142 3253-1408 9.78 µM -0.971526344966574 0.18800904046964 no 2774 0.165643120306194 4046 256655 SGTC_322 k048-0136 19.3 µM -0.974564025852532 0.187259312410815 no 2775 0.164888282713775 4133 6823282 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.974705139263271 0.187224529292235 no 2776 0.164853271476304 4028 756377 SGTC_2497 7-hydroxyflavone 100 µM -0.976274641193517 0.18683793131661 no 2777 0.164464191543621 4098 5281894 SGTC_2101 5377231 179.231 µM -0.976547683953477 0.186770726211199 no 2778 0.164396565004249 4103 2844213 SGTC_759 3486-0358 89.3 µM -0.978211584701321 0.18636150716392 no 2779 0.163984843994277 4061 875103 SGTC_668 1682-0499 62.6 µM -0.978349058071371 0.186327721881573 no 2780 0.163950857082623 4050 682214 SGTC_1414 3917-0015 5.4 µM -0.978933224759111 0.186184200138426 no 2781 0.163806487206488 4023 6618702 SGTC_1545 lovastatin 49.4 µM -0.979354373839963 0.186080772099149 no 2782 0.163702456401309 4122 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2302 7771753 200 µM -0.981027583070534 0.185670208388438 no 2783 0.163289569775553 4073 2203047 SGTC_369 0957-0393 4.5 µM -0.982268103075633 0.185366178893851 no 2784 0.162983892114894 4104 6997992 SGTC_2723 salbutamol 83.58 µM -0.983296762245132 0.185114307286312 no 2785 0.162730701590464 4095 9884233 β2-adrenoceptor agonist SGTC_2608 thymoquinone 42.66 µM -0.985767209978939 0.184510276448254 no 2786 0.162123679899518 4064 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1267 0828-0272 9.49 µM -0.988232505749987 0.183908728824204 no 2787 0.16151939597084 4165 745334 SGTC_591 4299-0174 154 µM -0.99179311995895 0.18304207529795 no 2788 0.160649227261996 4083 5509088 SGTC_2336 9001819 198.65 µM -0.997507152864366 0.181656615402933 no 2789 0.159259201795948 4160 2989602 SGTC_2605 digitonin 300 nM -0.997847117150741 0.181574392892061 no 2790 0.159176749309471 4131 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2321 7390090 138.78 µM -1.00162753741213 0.180661644498506 no 2791 0.158261757999988 4132 649046 SGTC_716 1683-5115 658 µM -1.00193224108134 0.180588202046581 no 2792 0.158188159862356 4017 723597 SGTC_2160 5660466 132.927 µM -1.00538064795157 0.179758341085441 no 2793 0.157356797323625 3982 2859134 SGTC_543 3844-1095 191 µM -1.00810545688931 0.179104311624615 no 2794 0.156701919117021 4095 4230703 SGTC_266 formosanin C 406 nM -1.00862663862236 0.178979384366026 no 2795 0.156576863419199 3988 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2898 9056270 58.44 µM -1.00926001557853 0.178827637741502 no 2796 0.15642497534423 4057 19154699 SGTC_3183 9108214 49.47 µM -1.01156242109725 0.178276702066264 no 2797 0.15587366064427 4032 4974831 SGTC_1282 0886-0010 32.4 µM -1.01208807730756 0.178151069513728 no 2798 0.155747971254096 4149 2836211 YNL267W PIK1 SGTC_2285 7945142 200 µM -1.01315680135461 0.177895815129383 no 2799 0.15549263531096 4153 2970608 SGTC_984 1492-0255 2.91 µM -1.01502080343244 0.177451168590178 no 2800 0.155047955484861 4079 1585198 SGTC_537 1334-0398 209 µM -1.01643633320808 0.177113971547084 no 2801 0.154710825574436 4155 5846986 SGTC_2182 6325192 200 µM -1.01701743474714 0.176975663099439 no 2802 0.154572567755325 4051 736248 SGTC_2282 7944268 200 µM -1.01847876435084 0.176628152568734 no 2803 0.154225243825214 4138 2970414 SGTC_254 nsc-64875 3.808 µM -1.01918126270808 0.176461249086697 no 2804 0.154058460213815 4114 56993 SGTC_1418 3966-3099 2.4 µM -1.02008018872589 0.176247822784015 no 2805 0.153845215841288 4116 740335 SGTC_1404 3909-7820 48.3 µM -1.02030235449413 0.176195100561133 no 2806 0.153792543517171 4086 23741373 SGTC_325 2810-4341 181 µM -1.02046142470764 0.176157357695368 no 2807 0.153754837580038 4107 774970 SGTC_2948 9070189 9.45 µM -1.02074965065817 0.176088982861655 no 2808 0.153686532212022 4055 6473636 YDL196W YDL196W SGTC_2892 9047358 58.44 µM -1.02236122939506 0.175706983336044 no 2809 0.153304981689797 4122 6466771 SGTC_965 1291-5240 308 µM -1.02300747800703 0.175553947805141 no 2810 0.153152155065867 4135 2834598 SGTC_32 0928-0142 34.1 µM -1.02375712241561 0.17537653339291 no 2811 0.152975003658829 4106 2244242 SGTC_1876 myriocin 605 nM -1.02674637607518 0.174670213275121 no 2812 0.152269952804357 4121 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_285 1486-1325 46 µM -1.02982325140755 0.17394507842801 no 2813 0.151546491891979 4171 22310230 SGTC_3124 9127567 49.47 µM -1.03056798995707 0.173769852182113 no 2814 0.151371726723858 4121 17592030 SGTC_333 3486-0131 40.1 µM -1.03172774337507 0.173497202573704 no 2815 0.151099838456618 4163 6744690 SGTC_2564 betulinic acid 100 µM -1.03425755936398 0.17290340650015 no 2816 0.150507885940027 4183 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_259 usnic acid 108.925 µM -1.03554298216466 0.172602190012457 no 2817 0.150207702078869 4214 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_993 3909-8757 62.7 µM -1.03584924792309 0.17253047134215 no 2818 0.150136238962449 4066 4288324 YLR208W SEC13 SGTC_24 0417-1663 219 µM -1.03589076350244 0.172520751045136 no 2819 0.150126553588615 4144 4329390 SGTC_2523 spermine 47.74 µM -1.03620098041321 0.172448129113779 no 2820 0.150054194742956 4147 1103 A DNA binding polyamine. SGTC_842 0271-0008 11.1 µM -1.03756626786347 0.172128746431829 no 2821 0.149736014533285 4179 1221709 SGTC_18 0111-0177 500 nM -1.03826515984794 0.171965400308556 no 2822 0.149573312069787 4198 721752 SGTC_542 3381-0244 89.3 µM -1.03983434044899 0.171599009659029 no 2823 0.149208435863474 4148 1112843 SGTC_1968 st069590 43.6 µM -1.04102383154431 0.171321605948336 no 2824 0.148932243946948 4127 6384066 SGTC_555 4296-0685 37 µM -1.04311143483693 0.170835445120224 no 2825 0.148448342655166 4094 2908540 YHR072W ERG7 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.04392407816078 0.170646435780941 no 2826 0.148260258572248 4178 23665772 A membrane-active detergent. SGTC_2081 5214970 32.255 µM -1.04426491322969 0.170567202229174 no 2827 0.148181420699451 4101 2063512 SGTC_195 4234-0266 16.654 µM -1.04466720932042 0.170473711215839 no 2828 0.148088402501357 4123 2303354 SGTC_2819 7996655 46.38 µM -1.04592180041944 0.170182363140133 no 2829 0.147798569136794 4084 6456960 SGTC_1788 fluconazole 20 µM -1.04605257584331 0.170152012121555 no 2830 0.147768379509494 4184 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2989 9073649 71.4286 µM -1.05066476095922 0.169083811770706 no 2831 0.146706293035332 4071 21367202 SGTC_2851 9015922 71.43 µM -1.05162470265187 0.168862028087015 no 2832 0.14648588481079 4173 2996893 SGTC_1169 aniline yellow 25.8 µM -1.05188582972505 0.16880172997763 no 2833 0.146425966984818 4066 6051 A DNA damaging agent. SGTC_34 0469-0683 81.75 µM -1.05266451237732 0.168622002772811 no 2834 0.146247389332035 4107 3690923 SGTC_2576 guaiol 23.12 µM -1.05365250948046 0.168394140958298 no 2835 0.146021019562106 4067 227829 SGTC_2226 7298446 200 µM -1.0545925282334 0.168177528307224 no 2836 0.145805861236881 4132 3283010 SGTC_773 4358-1457 44.6 µM -1.05947942408334 0.167054309513308 no 2837 0.144690747548376 4159 1186886 SGTC_2170 morpholine 200 µM -1.06005250359283 0.1669229088206 no 2838 0.144560357023281 4195 121171 Reacts with secondary amines. SGTC_3252 9135871 49.47 µM -1.06044321903152 0.166833360390231 no 2839 0.144471504476269 4178 17682838 SGTC_2768 sulfasalazine 50.2 µM -1.06404766686643 0.166008715758819 no 2840 0.143653553243424 4107 5384001 An antioxidant and salicylic acid derivative. SGTC_1483 3453-0561 55.9 µM -1.06466613467626 0.165867484619307 no 2841 0.143513520145593 4163 4546991 SGTC_2891 9063876 19.48 µM -1.06917039681144 0.164841250437285 no 2842 0.142496447668096 4155 6472478 SGTC_3231 9132313 49.47 µM -1.07283857899588 0.164008550466551 no 2843 0.141671774008931 4124 4905967 SGTC_2996 9066192 71.4286 µM -1.07311054078947 0.163946922316825 no 2844 0.141610761076067 4208 6472854 SGTC_2761 levamisole 97.89 µM -1.0734662155039 0.16386634700287 no 2845 0.141530994538649 4170 26879 An alkaline phosphatase inhibitor. SGTC_2670 beta-carotene 100 µM -1.07484431663446 0.163554391749121 no 2846 0.141222217780762 4102 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_648 0375-0473 33.3 µM -1.07611634072875 0.163266791214893 no 2847 0.14093761422074 4148 1713139 SGTC_844 0330-0132 15.3 µM -1.07880364837882 0.16266028069448 no 2848 0.140337634057687 4218 2828079 SGTC_902 1120-0002 2.07 µM -1.08097264812181 0.162171819698404 no 2849 0.139854640321342 4155 3280475 SGTC_2789 5281112 71.43 µM -1.08127486356777 0.162103836355823 no 2850 0.139787432653895 4203 765948 SGTC_1642 st009582 77.7 µM -1.08219967818178 0.16189591468911 no 2851 0.139581905736262 4175 6739311 SGTC_3044 9093193 49.47 µM -1.08330796585346 0.161646972624453 no 2852 0.139335875357023 4206 25236277 SGTC_3244 9134489 49.47 µM -1.08442413522718 0.161396512497768 no 2853 0.139088393674786 4184 16584271 SGTC_2008 4012253 172 µM -1.08806438938267 0.160581426092187 no 2854 0.138283341532316 4178 603940 SGTC_2135 5326629 150.42 µM -1.08872617722237 0.160433535048417 no 2855 0.138137327264085 4140 5020077 SGTC_1387 3342-1166 1.8 µM -1.09056666214449 0.160022706284308 no 2856 0.137731802803496 4151 3418228 SGTC_680 0417-1641 114 µM -1.09196849881647 0.159710253511375 no 2857 0.137423473746149 4175 2835990 SGTC_2316 5844804 197.44 µM -1.09236399555072 0.159622174225177 no 2858 0.137336570929679 4197 776813 SGTC_1245 0418-0076 17.2 µM -1.09315914422886 0.159445186487963 no 2859 0.137161965863084 4233 6790114 SGTC_3150 9097574 49.47 µM -1.09328587515987 0.159416990026691 no 2860 0.137134151294742 4229 17217476 SGTC_2685 mycophenolic acid 18.85 µM -1.09488478703895 0.159061527337886 no 2861 0.136783557338778 4168 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_734 2023-0417 80 µM -1.09571179459679 0.158877874755557 no 2862 0.136602459734985 4180 3935732 SGTC_3250 9135583 49.47 µM -1.10052627072245 0.157811490340432 no 2863 0.135551444907766 4240 7699353 SGTC_1279 0874-0590 65.2 µM -1.10205898984961 0.157472988844462 no 2864 0.135218013422362 4255 3523074 SGTC_938 3126-1755 342 µM -1.10639080021785 0.15651888909726 no 2865 0.134278702860459 4201 1777771 SGTC_2833 9001315 45.46 µM -1.109170250237 0.155908712117005 no 2866 0.133678371934666 4160 2989378 SGTC_1725 st036284 20.55 µM -1.11076061306859 0.155560283548232 no 2867 0.133335702125965 4269 707914 SGTC_2161 5662504 8.5105 µM -1.1109287971866 0.155523466571078 no 2868 0.133299499458339 4165 2859334 SGTC_452 diindolylmethane 8 µM -1.11111213597597 0.15548333865279 no 2869 0.133260042359441 4204 3071 Inhibits expression of several cancer promoting factors. SGTC_931 2812-0076 566 µM -1.11115531696055 0.155473888493382 no 2870 0.133250750370596 4152 3450959 SGTC_1310 1188-0297 994 nM -1.11119705362635 0.155464754783328 no 2871 0.13324176960416 4076 1588352 SGTC_1222 0366-0074 1.18 µM -1.11531127914009 0.154566129437827 no 2872 0.13235852683375 4219 286520 SGTC_2054 5233173 129 µM -1.11918412235102 0.153723369611984 no 2873 0.131530798827434 4251 6889 SGTC_1578 josamycin 24.2 µM -1.1240604275209 0.152666583244808 no 2874 0.130493695822131 4220 5282165 A P450 substrate. SGTC_171 k064-0041 9.68 µM -1.12588783396632 0.152271794534389 no 2875 0.130106499791461 4237 53325 SGTC_2117 5521686 200 µM -1.12676821535851 0.152081841076053 no 2876 0.129920246173997 4180 803312 SGTC_85 0868-0259 160.055 µM -1.13264499935047 0.150817883038489 no 2877 0.12868168169954 4135 83173 SGTC_2797 7859098 81.82 µM -1.13668967483514 0.149952042846141 no 2878 0.127834018590482 4215 972681 SGTC_1455 4262-0120 131 µM -1.13736907424561 0.149806930201225 no 2879 0.127692014940531 4290 1529587 SGTC_1611 st001856 99.4 µM -1.13810737874802 0.149649342279564 no 2880 0.127537823695646 4202 647478 SGTC_1836 st055642 81 µM -1.13960456514847 0.149330113966558 no 2881 0.127225541289979 4225 8571 SGTC_2886 9058944 51.95 µM -1.13968183492959 0.149313650941839 no 2882 0.127209438845292 4091 4949929 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.14054204718084 0.149130456789984 no 2883 0.12703027279707 4234 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_381 3461-2219 42.7 µM -1.14332575431996 0.148538656958143 no 2884 0.126451682935666 4231 2883159 SGTC_1325 1431-0015 227 µM -1.14395870445825 0.148404314882084 no 2885 0.126320381679806 4241 1103340 SGTC_2972 9093619 59.92 µM -1.14409503242032 0.148375390254385 no 2886 0.12629211379924 4187 25236256 SGTC_186 3455-3465 67.277 µM -1.14489499183134 0.148205739295312 no 2887 0.12612632941585 4233 755278 SGTC_627 1391-0720 175 µM -1.14508764780809 0.148164901282832 no 2888 0.126086425877495 4207 997839 SGTC_1043 0916-0009 19.3 µM -1.14610458298132 0.147949462484183 no 2889 0.125875940770221 4269 3101130 SGTC_1654 st012436 41.8 µM -1.15122709535881 0.146867442419879 no 2890 0.124819410479555 4242 4323132 SGTC_776 4476-4378 112 µM -1.15253799502827 0.14659139834736 no 2891 0.124550032979355 4300 2892008 SGTC_564 3555-0129 330 µM -1.15434678137474 0.146211083308168 no 2892 0.124179012147 4113 563260 SGTC_155 k072-0202 43.6 µM -1.15490788188483 0.146093241219484 no 2893 0.12406407569486 4226 5857737 SGTC_669 0108-0021 26.2 µM -1.1567201530755 0.145713064726075 no 2894 0.123693356595817 4203 17201 SGTC_2502 avocadyne acetate 18.59 µM -1.15870418382659 0.145297619936039 no 2895 0.123288392432568 4186 3952079 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.15963664110275 0.145102644208282 no 2896 0.123098388115997 4288 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_21 0849-0113 22.993 µM -1.16695387173218 0.143578733802751 no 2897 0.121614499248001 4208 1560156 SGTC_684 1140-0066 328 µM -1.16853941933435 0.143249951656068 no 2898 0.121294624179771 4294 6813534 SGTC_2551 apiole 73.87 µM -1.16877135556072 0.143201899587168 no 2899 0.121247882035349 4159 10659 A possible DNA adduct former. SGTC_1208 2323-2347 50.3 µM -1.16897374429256 0.143159978003381 no 2900 0.121207104953201 4251 5412760 SGTC_3003 9075612 71.4286 µM -1.17029572679937 0.142886354436581 no 2901 0.120940990477958 4282 6501993 SGTC_315 k915-0449 187 µM -1.17116709428905 0.142706192431323 no 2902 0.120765809558471 4266 20970215 YNL149C PGA2 SGTC_3125 9127534 49.47 µM -1.17459687294904 0.141998551406168 no 2903 0.120078017477319 4146 1639235 SGTC_686 1319-0111 510 µM -1.17853024116427 0.14118993738684 no 2904 0.119292641776813 4310 4562600 SGTC_2141 5621638 7.665 µM -1.17907678936915 0.141077826626414 no 2905 0.119183800013133 4293 2856238 SGTC_2837 9008476 45.46 µM -1.17940253422625 0.14101103689683 no 2906 0.119118963247941 4267 2992805 SGTC_170 4197-0004 226 µM -1.17973620376814 0.14094264455207 no 2907 0.11905257496175 4272 218692 SGTC_365 0121-0052 13.6 µM -1.17977104190973 0.140935505065379 no 2908 0.119045644926007 4275 3101739 SGTC_3012 9080433 71.4286 µM -1.17986445928601 0.140916361968206 no 2909 0.11902706365991 4270 17688859 SGTC_1268 0828-0275 2.46 µM -1.18347588539665 0.140177660190779 no 2910 0.118310299040115 4331 745337 SGTC_1990 st072050 59.8 µM -1.18446883803768 0.139975017852003 no 2911 0.118113762341212 4266 17233948 SGTC_13 0199-0087 65 µM -1.18959326579342 0.138932387218528 no 2912 0.117103146977204 4361 4589825 SGTC_794 k038-0031 316 µM -1.19013163948918 0.138823155931493 no 2913 0.116997328191263 4265 6624242 SGTC_1220 1838-0075 193 µM -1.19213164502944 0.138417884686256 no 2914 0.116604815264282 4189 5529645 SGTC_1516 st013856 110 µM -1.19396943935635 0.138046194672695 no 2915 0.116244961361155 4326 5281404 A mutagen and neurotoxin. SGTC_1617 st002906 78 µM -1.19420307061082 0.137998992059032 no 2916 0.116199271130106 4264 5150859 SGTC_1914 st062367 72.6 µM -1.19479160688741 0.137880133605752 no 2917 0.116084230186763 4282 978205 SGTC_2941 9056145 11.23 µM -1.19893036317582 0.137046259417854 no 2918 0.1152775120979 4211 2119517 SGTC_2929 9013348 24.6 µM -1.20049339441241 0.136732239044421 no 2919 0.114973888268865 4269 2995952 SGTC_1686 st019653 115.5 µM -1.20160344073631 0.136509524438793 no 2920 0.114758603885915 4280 97252 SGTC_1350 1495-0454 146 µM -1.20252255869192 0.136325304694346 no 2921 0.114580565670414 4325 1069057 SGTC_1348 1493-0373 93.8 µM -1.20295424544845 0.136238840010651 no 2922 0.114497013447292 4307 3010129 SGTC_2861 9024595 19.48 µM -1.20721413170188 0.135387618497659 no 2923 0.113674844754986 4199 16482810 SGTC_2166 5933061 31.504 µM -1.20822053919056 0.135187049004403 no 2924 0.113481221704157 4411 2877375 SGTC_3270 9137563 49.47 µM -1.20884780950223 0.135062141826075 no 2925 0.113360660008882 4282 17015724 SGTC_425 3825-7017 13.1 µM -1.20933084142679 0.134966010526636 no 2926 0.113267883291255 4343 3397440 SGTC_2487 5918373 44.05 µM -1.20952868437951 0.134926650075286 no 2927 0.1132298989182 4365 2876279 SGTC_1389 3405-0187 19 µM -1.21107779532227 0.134618729817725 no 2928 0.112932795286237 4256 799890 SGTC_2918 7977171 22.06 µM -1.21120284505144 0.134593894457518 no 2929 0.112908836322537 4280 2236483 SGTC_2211 7117706 200 µM -1.2115032503291 0.134534245659092 no 2930 0.112851294855487 4222 822771 SGTC_1736 st036774 51 µM -1.21288379982785 0.134260355587008 no 2931 0.112587125123869 4348 1272247 SGTC_284 0988-0104 32.6 µM -1.21315773730483 0.134206054129718 no 2932 0.112534759430516 4265 4666532 SGTC_3157 9099274 49.47 µM -1.21388334655733 0.134062292609729 no 2933 0.112396136561321 4320 17217662 SGTC_3116 9124943 49.47 µM -1.21407810022822 0.13402372500508 no 2934 0.112358950931073 4268 41905195 YPL160W CDC60 SGTC_1946 st076057 65.1 µM -1.21518244842166 0.133805172082774 no 2935 0.112148256538104 4239 953009 SGTC_1086 cerivastatin 2.18 µM -1.21544053374149 0.133754131768862 no 2936 0.11209905815864 4295 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1170 0310-0127 64.8 µM -1.21605299924415 0.133633060934712 no 2937 0.11198236662451 4295 774975 SGTC_3306 9127676 59.7925 µM -1.21656751376621 0.13353141109244 no 2938 0.111884404596676 4265 41905287 SGTC_1753 st043925 64 µM -1.21924737762847 0.133002824795817 no 2939 0.111375157368151 4335 670181 SGTC_3230 9131665 49.47 µM -1.21965521296476 0.132922508299237 no 2940 0.111297803216839 4275 15943720 SGTC_2934 9036370 36.88 µM -1.22139937664831 0.132579400609871 no 2941 0.110967421552258 4283 6462800 SGTC_821 1114-0266 29.2 µM -1.22399820415114 0.13206929823052 no 2942 0.110476452496991 4322 3123235 SGTC_801 0866-0028 10.1 µM -1.22451165588182 0.131968677354985 no 2943 0.11037963599743 4315 6849771 SGTC_827 3253-0474 693 µM -1.230479403819 0.130803058869287 no 2944 0.109258817514052 4341 5402065 SGTC_2011 4012611 177 µM -1.23314789963411 0.130284158386573 no 2945 0.1087602946712 4284 2049887 SGTC_3176 9106582 49.47 µM -1.23369264838231 0.130178404929378 no 2946 0.108658727195486 4288 17018027 SGTC_2858 9025781 8.96 µM -1.23590441604784 0.129749639124159 no 2947 0.108247047672583 4179 4894980 YPL153C RAD53 SGTC_1352 1496-0991 99 µM -1.23851706100993 0.129244421768896 no 2948 0.107762199985395 4310 3000039 SGTC_657 3534-0529 86.7 µM -1.24060964724024 0.128840754868165 no 2949 0.107374993183943 4357 1049549 SGTC_52 0329-0193 875 nM -1.24197026850995 0.1285787561265 no 2950 0.107123765956271 4382 3739292 SGTC_8 0354-0001 70 µM -1.243936192694 0.12820085480674 no 2951 0.106761523801424 4301 4993152 SGTC_898 1000-0849 28.3 µM -1.24431530919957 0.128128067645757 no 2952 0.106691769395338 4330 6751807 SGTC_1066 ketoconazole 628 nM -1.24534040631064 0.127931401425062 no 2953 0.106503324445163 4390 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_173 1273-0061 2.693 µM -1.24561842276454 0.127878099779783 no 2954 0.106452257762535 4284 2847414 YPL266W DIM1 SGTC_2329 6138490 200 µM -1.24659860838419 0.127690300548394 no 2955 0.106272356126659 4378 720019 SGTC_1029 k015-0030 64.7 µM -1.25139923774713 0.126773290387967 no 2956 0.105394427626691 4352 2208316 SGTC_696 1560-0013 611 µM -1.25275130081547 0.126515850631764 no 2957 0.105148114851115 4381 1650269 SGTC_932 2857-0803 154 µM -1.25437746677722 0.126206702965657 no 2958 0.104852419398019 4354 674898 SGTC_1797 st048695 56.8 µM -1.25510277201037 0.126068986343264 no 2959 0.104720727159593 4288 592262 YIL048W NEO1 SGTC_2920 7982904 15.77 µM -1.25644557913883 0.125814298761648 no 2960 0.10447723257708 4346 6456808 SGTC_1501 4491-0275 38.4 µM -1.25817515399457 0.12548678283028 no 2961 0.104164209233021 4315 5104718 SGTC_1490 4089-0339 670 nM -1.25973326280147 0.125192245941569 no 2962 0.103882800905314 4308 742542 SGTC_3025 9087895 49.47 µM -1.2611736710819 0.124920388280741 no 2963 0.103623141205466 4308 17173641 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.27332001449447 0.122644327430539 no 2964 0.10145225367976 4251 6708630 An antioxidant. SGTC_2020 4017018 200 µM -1.27422447462519 0.122476015173024 no 2965 0.101291936881372 4393 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2893 9048488 25.97 µM -1.27581861294334 0.122179754470616 no 2966 0.101009823177659 4377 6467338 SGTC_1801 st050089 28.441 µM -1.27703022398208 0.121954920869222 no 2967 0.100795788499954 4383 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3278 9139605 49.47 µM -1.27822333800806 0.121733803814919 no 2968 0.100585344748111 4331 7958859 SGTC_749 1000-0129 128 µM -1.27995416035261 0.121413535512608 no 2969 0.100280628975125 4394 708470 SGTC_2710 st078562 53.7235 µM -1.28185787417187 0.121061960310928 no 2970 0.0999462538974133 4289 17250908 SGTC_899 1083-0020 478 µM -1.28318964431696 0.120816437022655 no 2971 0.0997128215761489 4413 767123 SGTC_912 3474-0017 2.18 µM -1.28483054947506 0.120514404234492 no 2972 0.0994257522131914 4377 3360550 SGTC_1114 scopoletin 1.73284 µM -1.28505417204377 0.120473284408243 no 2973 0.099386677219982 4373 5280460 A coumarin with genotoxic properties. SGTC_877 0771-0151 33.1 µM -1.28516647128832 0.120452638496052 no 2974 0.0993670586938163 4365 6166523 SGTC_1540 guanosine 70.6 µM -1.29095860954472 0.119391146573511 no 2975 0.098359015157852 4277 6802 Guanosine is a purine nucleoside SGTC_2751 anetholtrithion 17.25 µM -1.29317049810899 0.118987533233431 no 2976 0.09797604840387 4331 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1225 1216-0074 20.6 µM -1.29516585487402 0.118624258893192 no 2977 0.0976315105079219 4367 4241466 SGTC_2478 5763493 32.33 µM -1.29554158456441 0.118555941375133 no 2978 0.0975667328461952 4301 1365576 YLR208W SEC13 SGTC_1128 3448-9350 235 µM -1.30249526885578 0.117296595481568 no 2979 0.0963735671207575 4384 619386 SGTC_3292 9120825 59.784 µM -1.30348982775571 0.117117253426101 no 2980 0.0962037934795819 4355 24824900 SGTC_855 0428-0020 25 µM -1.30351264559987 0.117113141120126 no 2981 0.0961999009991476 4384 6812414 SGTC_2647 atorvastatin 60.16 µM -1.30484469654159 0.116873251859364 no 2982 0.0959728679471306 4342 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1072 oxiconazole 14.9 nM -1.30818089023973 0.116273965340365 no 2983 0.0954059810659132 4370 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1090 efavirenz 20.7 µM -1.31014715402503 0.11592178474099 no 2984 0.0950730295675928 4397 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2264 7948757 110.76 µM -1.31284630644466 0.115439569728552 no 2985 0.0946173713832384 4322 2971411 SGTC_518 1021-0119 62.6 µM -1.31320238897472 0.115376060662555 no 2986 0.094557379604502 4349 1097762 SGTC_837 0091-0265 12.5 µM -1.31487086560402 0.115078810443014 no 2987 0.0942766528722053 4361 759367 SGTC_1643 st009866 20.2 µM -1.31519529672113 0.115021074175239 no 2988 0.094222137718787 4344 3156273 YOR207C RET1 SGTC_2294 7971431 200 µM -1.31786907276816 0.114546029193006 no 2989 0.0937737401852519 4373 5741572 SGTC_1630 st005209 31.3 µM -1.32388231007183 0.113482774028078 no 2990 0.0927710670697466 4368 3367314 SGTC_1146 3579-1023 7 µM -1.32484700470286 0.113312854846107 no 2991 0.0926109504809442 4404 X1146 SGTC_261 5-fluorouridine 15.376 µM -1.32783916346467 0.112786977242661 no 2992 0.0921156229802089 4399 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2569 tetrandrine 100 µM -1.32922942543948 0.112543229861517 no 2993 0.0918861449440087 4382 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3102 9121669 49.47 µM -1.32949904460315 0.112496002533648 no 2994 0.0918416903951695 4423 41905072 SGTC_1804 st050076 49.1 µM -1.32978225105697 0.112446410461114 no 2995 0.0917950127437574 4413 3895976 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.3312644319119 0.112187121629992 no 2996 0.0915510086045865 4322 97141 SGTC_1265 0819-1001 68.8 µM -1.33255030410896 0.111962520943305 no 2997 0.0913397114578204 4342 3106768 SGTC_1679 SEC14.276 6.7 µM -1.33424996110264 0.111666138915903 no 2998 0.0910609753888084 4368 1005053 YMR079W SEC14 SGTC_1603 st002045 67.8 µM -1.33512885497434 0.111513099902105 no 2999 0.0909170884654241 4387 5887985 SGTC_2219 9098279 200 µM -1.33575531581032 0.111404107911853 no 3000 0.0908146312851498 4334 902349 SGTC_180 1486-1293 102.781 µM -1.34328401800401 0.110100221058387 no 3001 0.0895900125618797 4342 4140536 SGTC_2124 5246320 200 µM -1.3442872906937 0.109927295563173 no 3002 0.0894277518809899 4406 579342 SGTC_2820 7989630 71.43 µM -1.34604249201329 0.109625235505476 no 3003 0.089144406630757 4425 2984098 SGTC_2349 9023730 187.07 µM -1.34612991060906 0.109610206862571 no 3004 0.0891303119783631 4437 4126287 SGTC_237 nikkomycin 200 µM -1.35076530946321 0.108815426040149 no 3005 0.0883853119563802 4425 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3246 9135460 32.98 µM -1.35211980332329 0.108583970118413 no 3006 0.0881684965852957 4368 41446951 SGTC_1650 st011916 45.8 µM -1.35438524348648 0.108197643529355 no 3007 0.0878067514925571 4346 242528 SGTC_2638 epoxomicin 18 µM -1.35513797317754 0.108069499418324 no 3008 0.0876868011114919 4381 9915668 A protesome inhibitor. SGTC_2338 7999974 200 µM -1.35523002228355 0.108053836551979 no 3009 0.0876721411242106 4395 315925 SGTC_2172 5754775 163.918 µM -1.35672841496578 0.107799103276551 no 3010 0.0874337601819117 4396 2263357 SGTC_1569 carminic acid 40.6 µM -1.35743678631468 0.107678827766118 no 3011 0.0873212331639806 4487 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1509 1326-1131 80 µM -1.36014650999565 0.107219631757355 no 3012 0.0868917827431659 4387 768313 SGTC_376 3970-0862 59.1 µM -1.36056496073559 0.107148846179162 no 3013 0.0868256054906437 4439 3135186 SGTC_1305 1181-0477 144 µM -1.36197180446988 0.106911110099785 no 3014 0.0866033917486829 4470 6252086 SGTC_2104 5389443 200 µM -1.36221632804351 0.106869828029883 no 3015 0.0865648121707944 4439 2244536 SGTC_695 3505-6186 243 µM -1.36562209087747 0.106296040115709 no 3016 0.0860288045898313 4405 1819379 SGTC_1795 st049545 62.3 µM -1.37092367506658 0.105407285434843 no 3017 0.0851993750977186 4362 5291882 SGTC_2997 9067075 71.4286 µM -1.3736599809204 0.104950681335467 no 3018 0.0847736331641719 4382 27209819 SGTC_1852 st056254 31.4 µM -1.37376223361931 0.104933646346271 no 3019 0.0847577546393862 4376 442583 SGTC_1499 4480-0877 67.3 µM -1.37387117627735 0.104915499032758 no 3020 0.0847408397042326 4398 2861909 SGTC_547 1120-0019 610 nM -1.3748158381427 0.104758235597026 no 3021 0.0845942733126066 4371 3676939 SGTC_12 0849-0099 9.267 µM -1.37491577127989 0.10474160912786 no 3022 0.0845787795921354 4349 6071388 SGTC_3165 9101544 49.47 µM -1.3763030889056 0.104510990247048 no 3023 0.0843639084988236 4410 5002184 SGTC_853 0419-0306 21 µM -1.37761254303663 0.104293652592356 no 3024 0.0841614731130939 4444 762713 SGTC_2623 humulene 100 µM -1.37775883520163 0.104269391995259 no 3025 0.0841388797026414 4401 6187145 An anti-inflammatory. SGTC_2774 tamoxifen 10.92 µM -1.37902357775689 0.104059821898391 no 3026 0.0839437422423988 4398 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1375 2910-0797 186 µM -1.37974644950367 0.103940178009654 no 3027 0.0838323629088433 4407 742508 SGTC_2076 5212012 200 µM -1.38395920884393 0.103244900589648 no 3028 0.083185472655756 4392 604802 SGTC_210 3551-0445 56.827 µM -1.38601704620546 0.102906503659986 no 3029 0.0828708492274637 4427 2865180 YOR207C RET1 SGTC_1262 0737-0114 49.6 µM -1.38651931710118 0.102824031212949 no 3030 0.0827941929616468 4451 765919 SGTC_1078 idebenone 36.1 µM -1.38742251266291 0.102675848135042 no 3031 0.0826564820785128 4453 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_682 0kpi-0099 17 µM -1.38974985724981 0.102294726986021 no 3032 0.0823024246547053 4430 1714895 YML126C ERG13 SGTC_189 3970-0742 2.116 µM -1.39349530432986 0.101683542351728 no 3033 0.081735031998205 4401 2891807 SGTC_107 0358-0022 2.6945 µM -1.39613142723909 0.101254975015882 no 3034 0.0813374607735406 4465 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2272 7805186 180 µM -1.39628571410595 0.101229932679865 no 3035 0.081314237012839 4438 2956062 YPR165W RHO1 SGTC_1470 k295-0292 231 µM -1.3969957072321 0.101114751702927 no 3036 0.0812074310092938 4498 5045612 SGTC_2243 6634756 200 µM -1.39902909156378 0.100785407768653 no 3037 0.0809021297150081 4468 885676 SGTC_1492 4158-0558 28.5 µM -1.40676510905965 0.0995395671610615 no 3038 0.0797485259357433 4441 3967268 SGTC_1001 4048-4355 44.4 µM -1.40745772932731 0.0994285760746141 no 3039 0.0796458516084457 4428 21824233 SGTC_1773 st048542 73.5835 µM -1.41255601396475 0.0986143682785245 no 3040 0.0788931549787283 4419 3237138 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.41511519404914 0.0982075059594338 no 3041 0.0785173620055688 4483 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_722 3534-0461 190 µM -1.41763669207654 0.0978078383421917 no 3042 0.0781484309495633 4468 658262 SGTC_3061 glucosamine 200 µM -1.41770171602235 0.0977975475772398 no 3043 0.0781389344422473 4381 91431 and experimental redox chemotherapeutic SGTC_2544 sphondin 68.51 µM -1.41978975730436 0.0974675135859753 no 3044 0.077834448890162 4406 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3257 9139206 32.98 µM -1.41997936398171 0.0974375850261333 no 3045 0.077806844434608 4450 4910041 SGTC_624 k048-0052 28 µM -1.42113110196243 0.0972559331996045 no 3046 0.077639324843512 4440 6835531 SGTC_2090 5301565 104.445 µM -1.42124146364887 0.0972385400365088 no 3047 0.0776232871904716 4459 2056344 SGTC_1357 1503-1303 39.5 µM -1.42242452766709 0.0970522307778289 no 3048 0.0774515234431949 4431 292895 SGTC_1994 st072947 40.9 µM -1.42417448093635 0.0967771282625564 no 3049 0.0771979850607804 4492 5286565 YDL195W SEC31 SGTC_577 r071-0003 38.6 µM -1.42569652512247 0.0965383203455347 no 3050 0.0769779800016841 4405 4568517 YMR134W ERG29 SGTC_279 1273-0055 2.93 µM -1.42592635675733 0.0965022975397618 no 3051 0.0769448002647917 4486 2847562 SGTC_1871 st057448 67.3 µM -1.42824636899297 0.0961392218295687 no 3052 0.0766104792363533 4449 691747 SGTC_2602 kawain 100 µM -1.42858234655744 0.0960867255973658 no 3053 0.0765621555390247 4429 5369129 SGTC_2843 9000894 45.46 µM -1.42965052309603 0.0959199638713535 no 3054 0.0764086735954958 4425 2242070 SGTC_2899 9053889 58.44 µM -1.43392656512032 0.0952545275796866 no 3055 0.0757966100257339 4439 6470052 SGTC_2696 st077691 74.316 µM -1.43419759565848 0.0952124647320677 no 3056 0.0757579415013266 4468 757133 SGTC_3251 9135047 49.47 µM -1.43430387663032 0.0951959740872507 no 3057 0.0757427822628708 4506 17682963 SGTC_783 0848-0141 92.7 µM -1.43783080591602 0.0946499251282425 no 3058 0.0752410331630175 4387 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_508 roscovitine 141 µM -1.4426003645116 0.093915165707984 no 3059 0.0745665403225271 4526 160355 A CDKinase inhibitor. SGTC_1756 st041558 35.5 µM -1.45619150882726 0.0918445254248217 no 3060 0.0726698430888813 4536 3955792 SGTC_830 4076-0286 57.8 µM -1.46193699101812 0.090979430527507 no 3061 0.0718792385469163 4513 6866659 SGTC_2983 9022671 12.99 µM -1.46530361178185 0.0904753365102516 no 3062 0.0714190507812657 4450 6405161 SGTC_1111 tnp00062 510.699 nM -1.46541810325438 0.0904582298999534 no 3063 0.0714034406430222 4497 676306 SGTC_2022 5136654 200 µM -1.46779132112977 0.0901041789239056 no 3064 0.0710804578296217 4473 1713771 SGTC_1312 1218-2183 165 µM -1.47004399416195 0.0897690649465884 no 3065 0.0707749195801942 4523 6744073 SGTC_36 0335-0881 14.2 µM -1.47311840235647 0.0893132036382459 no 3066 0.0703595560891343 4366 23828853 SGTC_2448 5185112 27.17 µM -1.4747402551676 0.0890734165939361 no 3067 0.0701411945233662 4475 5718189 SGTC_1796 st049173 110.4 µM -1.48075329295164 0.0881885841559819 no 3068 0.0693361634792921 4466 94134 SGTC_1421 4029-0249 71.4 µM -1.48103234412218 0.0881476807910513 no 3069 0.0692989773853502 4552 2894095 SGTC_445 e6 berbamine 66 µM -1.48320671962104 0.0878294448150339 no 3070 0.0690097482226274 4496 6610268 A calcium/calmodulin antagonist. SGTC_2426 5582046 32.21 µM -1.48457423040518 0.0876297389004221 no 3071 0.0688283230113295 4474 2251934 SGTC_846 0335-0850 148 µM -1.48652221267524 0.0873458485426164 no 3072 0.0685705229622456 4466 6819598 SGTC_393 acivicin 6.25 µM -1.49066623749594 0.0867442013822361 no 3073 0.0680245722359346 4347 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_499 genistein 192 µM -1.49267669034406 0.0864534333647097 no 3074 0.0677609189133301 4580 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_81 0411-0046 9.971 µM -1.49663826842221 0.0858826114885607 no 3075 0.0672437034664314 4486 12925265 SGTC_2480 5767542 37.17 µM -1.49797711271668 0.0856903371673553 no 3076 0.067069598485942 4418 2867358 SGTC_2932 9016711 44.54 µM -1.49867201171545 0.0855906683506541 no 3077 0.0669793704900664 4476 7117328 SGTC_3284 9108171 64.8615 µM -1.49886940720747 0.0855623719079972 no 3078 0.0669537571339434 4472 8687505 SGTC_692 k241-0027 77.8 µM -1.50405363930624 0.0848217231836532 no 3079 0.0662837780273104 4517 3600480 SGTC_929 2805-0021 398 µM -1.50860415530362 0.0841755813887141 no 3080 0.0656999858260128 4522 3098024 SGTC_586 0957-0265 8.15 µM -1.51462748241615 0.0833260016301061 no 3081 0.0649333841957956 4398 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3007 9078383 71.4286 µM -1.52215761081475 0.0822729766754893 no 3082 0.0639847967672985 4511 6496995 SGTC_1656 st012921 11 µM -1.52261016498606 0.0822100115141066 no 3083 0.0639281325684018 4427 6732821 SGTC_1489 4065-0444 182 µM -1.5227379965161 0.0821922325220207 no 3084 0.0639121338836633 4511 2877968 SGTC_2432 5630864 12.22 µM -1.52288928084644 0.0821711954229232 no 3085 0.0638932039998488 4514 5714970 SGTC_1391 3442-0225 151 µM -1.52637241510846 0.0816879632559484 no 3086 0.0634585717188871 4481 5227075 SGTC_831 k061-1017 217 µM -1.53419314804464 0.0806107646648423 no 3087 0.0624910714087419 4557 1240153 SGTC_2711 st079103 59.1 µM -1.53837749101855 0.0800388522367656 no 3088 0.0619781712813899 4448 54693780 SGTC_306 1672-3436 11.6 µM -1.54088998911516 0.079696923242958 no 3089 0.0616717813441902 4524 6797378 SGTC_1033 k072-0102 21.3 µM -1.54157429215591 0.079603987333336 no 3090 0.0615885383393404 4474 5965931 SGTC_1398 3558-0053 112 µM -1.54231527136125 0.0795034466655247 no 3091 0.061498499852971 4493 4532369 SGTC_3091 9116372 49.47 µM -1.54778010949436 0.0787649091440312 no 3092 0.0608376234804227 4556 17169793 SGTC_2977 9011197 71.43 µM -1.55056338321254 0.0783907713689385 no 3093 0.0605031764611694 4548 2704722 SGTC_2421 5690543 90.72 µM -1.55200202831455 0.0781979124793086 no 3094 0.0603308691423622 4507 3397993 SGTC_1924 st058459 75.1 µM -1.5531450801972 0.07804493633705 no 3095 0.0601942391785764 4483 688683 SGTC_2000 st075254 36.4 µM -1.55420551931463 0.0779032194904181 no 3096 0.0600677007016225 4403 17234175 SGTC_2724 maprotiline 69.64 µM -1.55924872128992 0.0772319186585263 no 3097 0.0594687616854203 4468 4011 A tricyclic antidepressant. SGTC_2466 5983409 37.09 µM -1.56067067095141 0.0770434394298374 no 3098 0.059300737375516 4523 2879657 SGTC_2646 retinol 96.75 µM -1.56289940080681 0.0767487252379583 no 3099 0.0590381293177066 4533 445354 A vitamin A analog and teratogen. SGTC_1755 st041960 45.185 µM -1.56349076585472 0.0766706706738286 no 3100 0.0589686029856972 4544 2257073 SGTC_1830 st055982 50.3 µM -1.56677042986761 0.0762388816166894 no 3101 0.0585841807643354 4531 455313 An antimicrobial agent. SGTC_1510 1123-0200 71.5 µM -1.5685651106709 0.0760033850048408 no 3102 0.0583746536818359 4534 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1722 st034304 3.6505 µM -1.56891651933824 0.0759573383434354 no 3103 0.0583336960794869 4478 4036148 YLR033W RSC58 SGTC_1768 st044301 37.178 µM -1.57001685652862 0.0758132935894631 no 3104 0.0582055948704787 4537 3931349 SGTC_793 0488-0545 106 µM -1.57719214334919 0.0748790764421828 no 3105 0.0573756601171133 4556 292548 SGTC_3336 9143619 71.43 µM -1.5791036499247 0.0746316872125665 no 3106 0.0571561423231773 4531 45595730 SGTC_76 0433-0009 400.328 µM -1.58462857021648 0.0739201530203976 no 3107 0.0565253748547233 4578 2841569 SGTC_1716 st033144 30.6155 µM -1.58573295834844 0.0737785466240235 no 3108 0.0563999496942499 4500 674617 SGTC_1590 st077108 57.8 µM -1.59085543601687 0.0731244443099921 no 3109 0.05582105683049 4553 5489485 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.59116037260987 0.0730856465670779 no 3110 0.0557867442433058 4571 94937 An inhibitor of serotonin biosynthesis. SGTC_2965 9082772 38.63 µM -1.59152174292075 0.0730396890378448 no 3111 0.0557461030763005 4525 16459634 SGTC_3226 9131256 49.47 µM -1.59509072062726 0.0725869888666643 no 3112 0.0553459751201487 4555 17178073 SGTC_1961 st076550 68.7 µM -1.60724187790866 0.0710618032281761 no 3113 0.0540006593716699 4545 1579337 SGTC_146 3448-8650 53.125 µM -1.60943945849525 0.0707886151178138 no 3114 0.0537601415391673 4521 2891488 YIL048W NEO1 SGTC_2485 5633444 17.78 µM -1.61070481286817 0.0706316814494405 no 3115 0.0536220381045511 4516 5724239 SGTC_116 0155-0182 31.788 µM -1.61091773270319 0.0706053006899395 no 3116 0.0535988272340507 4418 771486 SGTC_703 3875-0075 71.8 µM -1.61107579660677 0.0705857214764372 no 3117 0.0535816014801301 4586 2850814 SGTC_1605 st000082 49.1 µM -1.61110254711519 0.0705824083313425 no 3118 0.0535786866522078 4507 1114022 SGTC_1053 3366-3204 134 µM -1.61292761344383 0.0703566495539238 no 3119 0.053380117584263 4548 3632071 YPR165W RHO1 SGTC_163 TUB2.036 7.546 µM -1.61470883853456 0.0701368496760015 no 3120 0.0531868813010617 4508 15992207 YJR013W GPI14 SGTC_1248 0469-0687 58.6 µM -1.61546533701758 0.0700436591207955 no 3121 0.0531049804909267 4503 4017482 SGTC_1714 st033236 13.627 µM -1.61705770150089 0.0698478123122255 no 3122 0.0529329130884659 4544 2916566 SGTC_2693 st077581 40.7 µM -1.61718565669374 0.0698320932615748 no 3123 0.0529191057482264 4503 25238761 SGTC_940 3232-1287 54.8 µM -1.61839368324605 0.069683823668913 no 3124 0.0527888912319571 4537 1585493 YIL048W NEO1 SGTC_1746 st038117 42 µM -1.61855449297296 0.0696641046517608 no 3125 0.052771576561815 4570 2898218 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.61886763449653 0.0696257185366711 no 3126 0.0527378729852985 4523 1241132 A phosphatase inhibitor. SGTC_2545 solidagenone 89.61 µM -1.62290867160799 0.0691318122621363 no 3127 0.0523044647803808 4509 6708572 An anti ulcer agent SGTC_1626 st003712 1.76 µM -1.62314236442497 0.0691033324975827 no 3128 0.0522794875891051 4547 24207035 SGTC_1320 1313-0481 95.3 µM -1.62349829894533 0.069059972708252 no 3129 0.0522414633507381 4514 6813365 YLR208W SEC13 SGTC_1710 st031758 61.5 µM -1.62821664865919 0.0684871647719454 no 3130 0.0517394779137735 4585 5394341 SGTC_774 k060-0086 136 µM -1.6291049053852 0.0683797414660336 no 3131 0.0516454064858825 4567 5911235 SGTC_410 α-linolenic acid 100 µM -1.62930630149472 0.0683554032687386 no 3132 0.0516240964168969 4588 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_137 0438-0332 85.389 µM -1.63120602730285 0.068126155120536 no 3133 0.0514234269766198 4505 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_477 mead ethanolamide 10 µM -1.6353159505343 0.0676322241977206 no 3134 0.0509914157651844 4576 16061185 SGTC_3100 9120536 49.47 µM -1.63905313569195 0.0671854949302751 no 3135 0.0506010969789016 4467 16421196 SGTC_1508 1080-0625 72.9 µM -1.64086917897077 0.0669692372123073 no 3136 0.0504122870595998 4519 767111 SGTC_2533 agelasine 13.65 µM -1.64483298051376 0.0664990910440099 no 3137 0.050002129419733 4583 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2097 5376186 200 µM -1.64521129217841 0.0664543534341185 no 3138 0.0499631228171814 4538 742755 SGTC_98 0074-0023 107.663 µM -1.64545122842956 0.0664259916199097 no 3139 0.0499383962747091 4556 3563821 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.65108355953623 0.0657629070668765 no 3140 0.0493607569192988 4553 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_129 0088-0017 176.636 µM -1.65169050330896 0.0656917599583542 no 3141 0.0492988298070312 4419 182446 SGTC_1685 st024049 53.0905 µM -1.65464704010043 0.0653460420601843 no 3142 0.0489980578187897 4592 1941139 SGTC_802 4112-3352 742 µM -1.65760875712807 0.0650011351593783 no 3143 0.0486982304860232 4597 704594 SGTC_1867 st057372 64 µM -1.66136320986958 0.0645659431382857 no 3144 0.0483202610087157 4551 688837 SGTC_102 gallobenzophenone 83.616 µM -1.66199810443695 0.0644925744894198 no 3145 0.0482565772768861 4553 70837 SGTC_1439 4092-1168 46 µM -1.66373737060358 0.0642919159980507 no 3146 0.0480824623304221 4593 2886240 SGTC_2245 6637752 200 µM -1.66380682512465 0.0642839131417924 no 3147 0.0480755198103206 4589 681890 SGTC_2653 dihydrofissinolide 100 µM -1.6654283422525 0.0640972947312468 no 3148 0.0479136644175286 4644 6857746 SGTC_2457 5731572 11.68 µM -1.6671116437947 0.0639040114685338 no 3149 0.047746103632806 4615 2865357 SGTC_882 0843-0131 351 µM -1.66712583220473 0.0639023842283794 no 3150 0.047744693273555 4590 5425421 SGTC_2348 9022543 33.42 µM -1.66761990395054 0.0638457402316543 no 3151 0.0476956022555502 4584 3162678 YDL140C RPO21 SGTC_1565 sinapyl alcohol 95.1 µM -1.67066473097452 0.0634975205103445 no 3152 0.0473939594691761 4581 5280507 A phenol propionate derived from cinnamic acid. SGTC_1553 gossypol 38.6 µM -1.67423555598126 0.0630910305249919 no 3153 0.0470421570802896 4519 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_83 0170-0301 39.027 µM -1.6784039002312 0.0626190880210149 no 3154 0.0466341383685908 4602 3089716 SGTC_2866 9034245 58.44 µM -1.67902269933122 0.062549262391495 no 3155 0.0465738099675422 4583 6462273 SGTC_2736 butenafine 14.65 µM -1.68559100238306 0.0618118279604344 no 3156 0.0459373017189607 4530 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2968 9090663 33.37 µM -1.68703991598636 0.0616500732835033 no 3157 0.0457978384823599 4528 25236811 SGTC_2063 5246145 200 µM -1.68720789140518 0.0616313421433348 no 3158 0.0457816922684739 4609 711240 SGTC_1009 4106-0057 9.87 µM -1.69106962536691 0.0612019398456946 no 3159 0.045411752827109 4574 2928005 SGTC_848 0368-0089 85.6 µM -1.69522695412388 0.060742286049179 no 3160 0.0450161877700568 4592 762535 SGTC_3119 9125183 49.47 µM -1.69750273322038 0.0604918111942983 no 3161 0.0448008274003112 4502 22695334 SGTC_2537 larixol 68.93 µM -1.70263493263524 0.0599299219060181 no 3162 0.0443182042581858 4559 6708759 SGTC_257 daunorubicin 18.5 µM -1.71854544125856 0.058213943096092 no 3163 0.0428485867046887 4625 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3201 9113999 49.47 µM -1.71973391067903 0.0580873298864762 no 3164 0.0427404103806211 4568 16649224 SGTC_2499 avocadenofuran 51.48 µM -1.72223187900725 0.0578219150817408 no 3165 0.0425137610721209 4559 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_222 nsc-310342 10.666 µM -1.72496890431298 0.0575321955772693 no 3166 0.0422665382900841 4617 432556 SGTC_59 0330-0160 1.33 µM -1.72853260458821 0.0571566835597579 no 3167 0.0419463903766053 4553 4293482 SGTC_1563 conessine 56.1 µM -1.72999634244939 0.0570030075177596 no 3168 0.0418154643532199 4646 441082 An anti-amoebic, histamine inhibitor. SGTC_3069 9117009 49.47 µM -1.73584617068938 0.0563920869541058 no 3169 0.041295518924567 4614 41904981 SGTC_419 nsc-638432 893 µM -1.74034142553201 0.0559261457103013 no 3170 0.0408995420615338 4592 368090 SGTC_1243 0416-0003 5.65 µM -1.7409999458286 0.0558581446653908 no 3171 0.0408417940088741 4587 2141977 SGTC_2065 5221596 34.26 µM -1.74472105068002 0.0554751157018974 no 3172 0.0405167185975031 4579 788581 SGTC_1798 st045719 60.953 µM -1.74711107765962 0.0552301958409854 no 3173 0.0403090361047858 4594 3980186 SGTC_2906 7926292 26.41 µM -1.74900808472933 0.0550364072013981 no 3174 0.0401448109597312 4599 2966319 SGTC_3282 9108498 15.4605 µM -1.74980037546271 0.0549556300091502 no 3175 0.0400763829422816 4594 16459645 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.75271904606938 0.0546588679412281 no 3176 0.0398251223961713 4607 140250 A respiratory chain inhibitor. SGTC_463 ikarugamyin 104 µM -1.7539126635638 0.0545378699786802 no 3177 0.0397227366779133 4738 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_46 0329-0187a 2.197 µM -1.75634780364151 0.0542916748447127 no 3178 0.0395145197470566 4603 46494817 SGTC_1794 st048918 76.9 µM -1.75797351322901 0.054127804003737 no 3179 0.0393760080779448 4602 672303 SGTC_3208 9114115 49.47 µM -1.7613074413957 0.0537929701268271 no 3180 0.0390931906240253 4556 650895 SGTC_2954 9074818 52.69 µM -1.76137915508073 0.0537857858224299 no 3181 0.0390871253607241 4599 16648742 SGTC_887 0885-0007 9.62 µM -1.76261360381368 0.0536622373510111 no 3182 0.0389828405459955 4624 5719458 SGTC_3190 9110366 49.47 µM -1.76730731964981 0.0531945230155351 no 3183 0.0385883873351715 4614 17123768 SGTC_387 norethindrone acetate 66.7 µM -1.77063629439404 0.0528647641668303 no 3184 0.0383106012127125 4614 541197 SGTC_1401 3807-4679 7.6 µM -1.77838930550541 0.0521030582709265 no 3185 0.0376699689574308 4549 3291456 SGTC_3315 9136395 68.55 µM -1.77894564062004 0.0520487372970376 no 3186 0.0376243372258888 4619 16876844 SGTC_1331 1472-0049 76.2 µM -1.78143604701799 0.0518061234354754 no 3187 0.0374206219127644 4605 24051409 SGTC_1148 3909-7663 27.7 µM -1.78547636671761 0.0514144308316257 no 3188 0.0370920406999511 4641 4084526 SGTC_2583 asiatic acid 100 µM -1.78784560419886 0.0511858407196302 no 3189 0.0369004604682221 4598 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1882 5615643 20 µM -1.78878415330553 0.0510955110208341 no 3190 0.0368247919896826 4611 2253075 SGTC_953 1188-0045 9.7 µM -1.79778755423483 0.0502354195112491 no 3191 0.0361053401845279 4593 6144426 SGTC_1906 st060206 94.7 µM -1.79947861303665 0.0500751680059602 no 3192 0.0359715020163364 4634 5133468 SGTC_2978 9011784 42.97 µM -1.80191430499867 0.0498450686923294 no 3193 0.0357794446095867 4604 2994934 SGTC_2847 9005661 71.43 µM -1.81576863344785 0.0485522516531387 no 3194 0.0347029353782076 4664 2991449 SGTC_438 sphingosine 6.67 µM -1.81787590730332 0.0483579816842983 no 3195 0.0345415507209557 4584 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2382 9035899 200 µM -1.82034402391519 0.0481312366497558 no 3196 0.0343533155382494 4623 6462679 SGTC_327 1273-0057 3.96 µM -1.83646598978397 0.0466709722691049 no 3197 0.033144383824178 4568 3108138 SGTC_2046 4110841 106 µM -1.83829075195956 0.0465079560862509 no 3198 0.033009786558801 4648 44119630 YMR134W ERG29 SGTC_742 0kpi-0133 140 µM -1.8421733440622 0.0461626231568496 no 3199 0.0327248990923532 4658 2728852 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.84398479255484 0.046002211904478 no 3200 0.0325926782404602 4657 688664 SGTC_1920 st075728 45.7 µM -1.8442395110229 0.045979691486416 no 3201 0.0325741212688308 4614 3400306 SGTC_1986 st071812 45 µM -1.84448332630729 0.0459581433489805 no 3202 0.0325563667891791 4599 11838594 SGTC_592 k241-0073 46.5 µM -1.84850182039592 0.0456041605803022 no 3203 0.0322648906395666 4679 4230158 SGTC_951 1171-0579 82.7 µM -1.84862708062742 0.0455931619331016 no 3204 0.0322558397809343 4566 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1514 1189-1591 158 µM -1.85006068927071 0.0454674337744973 no 3205 0.0321524014764614 4638 767698 YMR146C TIF34 SGTC_1822 st052468 42 µM -1.85155762345587 0.0453364496531099 no 3206 0.0320446864769622 4663 2873678 SGTC_1041 0206-0046 107 µM -1.85329953356864 0.0451844120334682 no 3207 0.0319197190010149 4650 50494 SGTC_1050 3232-1156 69.3 µM -1.85344480594583 0.0451717509069398 no 3208 0.0319093151324662 4604 700529 SGTC_1374 2889-5571 141 µM -1.85556150696891 0.0449875947260373 no 3209 0.0317580423099863 4640 2853281 SGTC_1548 st061468 90.8 µM -1.86229111504189 0.0444061203276127 no 3210 0.0312810335904236 4693 390799 SGTC_433 pimozide 108 µM -1.86655629786717 0.0440407315899791 no 3211 0.0309817876464217 4582 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1907 st060210 83.7 µM -1.86834947434687 0.0438878397904037 no 3212 0.0308566873790232 4642 688793 SGTC_411 enrofloxacin 100 µM -1.87246118010484 0.0435388790785262 no 3213 0.0305714138615896 4676 71188 A bacterial gyrase inhibitor. SGTC_3253 9135987 49.47 µM -1.87609467571311 0.0432323711970908 no 3214 0.0303211403377852 4661 4182430 SGTC_63 0099-0242 26.702 µM -1.87811004808644 0.0430631148209654 no 3215 0.03018305601775 4649 3898502 YLR359W ADE13 SGTC_3090 9117696 49.47 µM -1.88224178206187 0.0427177944470183 no 3216 0.0299015975265912 4628 7923821 SGTC_324 1315-0088 19.6 µM -1.8867146194682 0.0423464923912316 no 3217 0.0295993601264723 4646 6787421 SGTC_1507 4075-3230 155 µM -1.89053337246539 0.0420315575500859 no 3218 0.0293433308151694 4625 659771 SGTC_394 menadione 8.33 µM -1.90051854029041 0.0412170278878322 no 3219 0.0286825521292666 4659 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2239 6685329 187.64 µM -1.90206247631033 0.0410922328930715 no 3220 0.0285814936633429 4640 805680 SGTC_1342 1486-1464 234 µM -1.90260790047608 0.0410482200443921 no 3221 0.0285458637448334 4678 3253938 SGTC_1317 1273-0028 910 nM -1.90307482602325 0.041010571999665 no 3222 0.0285153911216242 4664 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2255 7941087 197.44 µM -1.90478484694658 0.0408729326297945 no 3223 0.028404022205319 4703 935561 SGTC_2350 9023895 38.85 µM -1.90689363631131 0.0407037127233114 no 3224 0.0282671812080305 4608 2997209 SGTC_2998 9066762 71.4286 µM -1.90839175800089 0.0405838416445892 no 3225 0.0281703006577684 4648 4945196 SGTC_3010 9080089 71.4286 µM -1.91247384367867 0.0402586702291882 no 3226 0.0279077222074876 4669 17027233 SGTC_2440 5628896 157.78 µM -1.91392256740006 0.0401437775948197 no 3227 0.0278150251927774 4627 5522048 SGTC_2955 9076254 12.21 µM -1.91758226061062 0.0398547276632638 no 3228 0.0275820006220875 4619 16459619 SGTC_1452 4194-0072 190 µM -1.91904596668416 0.0397395958553405 no 3229 0.0274892583765767 4694 1343545 SGTC_819 1013-0258 27.7 µM -1.92129770262687 0.0395630075118599 no 3230 0.0273470933097422 4661 5753198 SGTC_151 3013-0144 2.285 µM -1.9213859680374 0.0395560984755591 no 3231 0.027341533118255 4435 906558 YHR107C CDC12 SGTC_1969 st069479 40.1 µM -1.92455311465097 0.0393088365192913 no 3232 0.0271426448888819 4661 3895485 SGTC_606 k015-0008 38.6 µM -1.92595576249481 0.0391997331247372 no 3233 0.0270549488783501 4702 1970475 SGTC_3162 9099653 49.47 µM -1.92754325481008 0.0390765492693352 no 3234 0.0269559814482577 4650 25237511 SGTC_1984 st072354 53.1 µM -1.93418468904698 0.0385646099332381 no 3235 0.0265452120999946 4588 5762938 SGTC_913 3487-1245 167 µM -1.93777779017932 0.0382899306110821 no 3236 0.0263251692723005 4601 4016153 SGTC_1973 st070275 50.2 µM -1.93895302193149 0.0382004354478931 no 3237 0.0262535293820818 4667 17118334 SGTC_1944 st076371 56.9 µM -1.94510017161904 0.0377350991033133 no 3238 0.025881461629967 4656 24208455 SGTC_2873 9040596 71.43 µM -1.95517117392607 0.0369827364325571 no 3239 0.0252814348688759 4646 6463863 SGTC_2829 7992743 58.44 µM -1.95635350017672 0.0368952196965069 no 3240 0.0252117629293449 4636 16462845 SGTC_2340 7987427 183.45 µM -1.95885449533539 0.0367106519202765 no 3241 0.0250649147155592 4640 2239331 SGTC_3209 9113616 49.47 µM -1.96573846322713 0.0362065277743759 no 3242 0.0246644146812187 4668 16649353 SGTC_910 3454-3003 490 µM -1.98281188508989 0.0349806409975161 no 3243 0.0236942229756633 4602 820824 SGTC_3081 9117243 49.47 µM -1.98493045131541 0.0348309302174203 no 3244 0.0235761049384376 4642 45595589 SGTC_2874 9043904 71.43 µM -1.98743675863562 0.0346544989785912 no 3245 0.023437008799242 4613 4463428 SGTC_1987 st072290 61.9 µM -1.98849839282032 0.0345799869745084 no 3246 0.0233782982897612 4689 54697379 SGTC_594 1487-1584 10.8 µM -1.99264146797502 0.0342904584201413 no 3247 0.0231503604763195 4669 5013332 SGTC_3105 9121040 49.47 µM -1.99917619297315 0.0338378471946173 no 3248 0.0227946467422761 4673 41448907 SGTC_228 caffeine 993.056 µM -2.00045499527409 0.0337498517095262 no 3249 0.0227255774882775 4674 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2283 7944793 200 µM -2.01514108013594 0.0327527223867113 no 3250 0.0219449344847264 4652 2970533 SGTC_3144 9087057 49.47 µM -2.02567483575913 0.032052582291004 no 3251 0.0213990585311705 4630 17249618 SGTC_2753 fluvastatin 17.09 µM -2.03936013197182 0.0311614732656935 no 3252 0.0207070491543863 4664 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1311 1190-0148 100 µM -2.05788618765441 0.0299879043921003 no 3253 0.0198005299705718 4705 1961333 SGTC_1376 2910-0861 41.3 µM -2.05895686496311 0.0299212159743932 no 3254 0.0197491854225723 4658 1112859 SGTC_3034 9090421 49.47 µM -2.05912978599678 0.0299104569265134 no 3255 0.019740903569037 4680 17173761 SGTC_2737 bleomycin 30.5 nM -2.06650339951436 0.0294546518745884 no 3256 0.0193904858732575 4751 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2287 7945887 168.79 µM -2.07272608924904 0.0290744925478331 no 3257 0.0190988891699597 4721 1245853 SGTC_2077 5212015 200 µM -2.07527702512704 0.0289198322135286 no 3258 0.0189804337467761 4665 780900 SGTC_2976 9009005 19.48 µM -2.07592988713883 0.0288803600184282 no 3259 0.0189502180223667 4671 2993148 SGTC_2118 5526350 200 µM -2.076330264568 0.0288561752628213 no 3260 0.0189317080225231 4700 743594 SGTC_1525 8-methoxypsoralen 92.5 µM -2.08548343308474 0.0283078548525315 no 3261 0.0185127202154547 4706 4114 Related to psoralen; DNA damaging agent. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.08644365425649 0.0282508387300498 no 3262 0.0184692270726956 4692 688761 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.08727170171947 0.0282017476204307 no 3263 0.0184317906329908 4728 16486 A toxic proline analog. SGTC_2393 9031399 185.94 µM -2.09465576664395 0.0277671128419284 no 3264 0.0181008020018977 4678 1526623 YDL150W RPC53 SGTC_2075 5212009 200 µM -2.09539442986255 0.0277239430096521 no 3265 0.018067972139048 4672 780898 SGTC_281 1672-3440 14.9 µM -2.09595631037573 0.0276911423876489 no 3266 0.0180430333820268 4726 6833000 SGTC_2191 5911152 200 µM -2.0981244821649 0.0275648751221525 no 3267 0.0179470751975255 4712 2875902 SGTC_1211 1056-0033 32.3 µM -2.10133328988584 0.0273788856676007 no 3268 0.0178058597172848 4714 6741922 SGTC_3094 9117742 49.47 µM -2.11456065066647 0.0266232130538035 no 3269 0.0172337051917005 4681 17149698 SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.12732570926442 0.0259105503501955 no 3270 0.0166965150288845 4698 5282309 SGTC_383 2324-0395 7.37 µM -2.12939204214021 0.0257967032876497 no 3271 0.0166109191532198 4705 3146421 SGTC_2909 7941780 10.49 µM -2.14195268758534 0.0251136314097434 no 3272 0.0160986447225575 4695 1243215 SGTC_1846 st056244 14.8 µM -2.14338678644772 0.025036615544443 no 3273 0.0160410266122107 4711 5393182 SGTC_589 1227-0070 34.1 µM -2.14965219129228 0.0247024608004215 no 3274 0.0157913683841851 4734 2841384 SGTC_2958 9077254 16.72 µM -2.15082356235576 0.0246404046981522 no 3275 0.0157450642892207 4701 16457351 SGTC_942 3253-1115 227 µM -2.15284383195884 0.02453368357887 no 3276 0.0156654770154802 4710 46497897 SGTC_3013 9080133 71.4286 µM -2.1549310013034 0.0244238361518015 no 3277 0.0155836169990349 4732 17050193 SGTC_200 k038-0079 37.545 µM -2.15780753334368 0.0242731215633305 no 3278 0.0154713994699578 4727 3436683 SGTC_2840 9008771 71.43 µM -2.16132026536661 0.0240901335260995 no 3279 0.0153353042754418 4687 2992978 SGTC_2798 7813637 45.45 µM -2.16293211522419 0.0240065564619791 no 3280 0.0152732006224539 4696 956368 SGTC_2754 granisetron 64.02 µM -2.16316512004609 0.02399449495887 no 3281 0.0152642409742595 4692 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2206 7254556 146.969 µM -2.16574887706808 0.0238610876613229 no 3282 0.0151651909249257 4736 4398905 SGTC_350 k064-0020 19.8 µM -2.16649128016783 0.0238228706211149 no 3283 0.0151368327368109 4709 2790705 SGTC_2707 st078556 66.6 µM -2.1884563534499 0.0227152300793234 no 3284 0.0143181886189348 4675 17250899 SGTC_2299 7976368 114.88 µM -2.18926133940024 0.0226754754189694 no 3285 0.014288925298525 4714 2979718 SGTC_2804 7954240 19.48 µM -2.19001035369612 0.0226385376343621 no 3286 0.014261742970554 4701 828705 SGTC_2663 amphotericin b 100 µM -2.19007188745724 0.0226355053409647 no 3287 0.0142595118423067 4735 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_541 4513-1321 94 µM -2.22585502813249 0.0209292098191594 no 3288 0.0130119467549315 4719 747515 SGTC_2284 7945075 39.21 µM -2.23345069261069 0.0205813762549821 no 3289 0.0127596192226704 4686 1245402 SGTC_723 4182-0001 115 µM -2.24623385223638 0.0200070450123091 no 3290 0.0123445164879891 4715 744821 YLR208W SEC13 SGTC_2644 guaiazulene 100 µM -2.24892136097119 0.0198880440707002 no 3291 0.0122587498531226 4756 3515 A coloring agent. SGTC_936 3005-4620 401 µM -2.25793209096132 0.0194934290067522 no 3292 0.0119749467708989 4736 777207 SGTC_3096 9117468 49.47 µM -2.26799749776512 0.0190605091273633 no 3293 0.0116646795939173 4737 41316311 SGTC_1294 1000-1494 117 µM -2.28635650676407 0.0182919167505614 no 3294 0.0111167052966954 4751 712797 YDL207W GLE1 SGTC_326 k292-0812 17.5 µM -2.28856451668393 0.0182012831222558 no 3295 0.0110523337682608 4750 3579357 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.30736752133892 0.0174448547548841 no 3296 0.0105171701276451 4704 6708514 SGTC_566 0958-0068 16.5 µM -2.30884014762441 0.0173867625846012 no 3297 0.0104762266354496 4685 6815365 SGTC_1302 1159-0335 255 µM -2.31303090703703 0.0172223487191273 no 3298 0.0103604699582381 4756 649284 SGTC_1030 k029-0042 36.7 µM -2.32461853671817 0.0167746355107011 no 3299 0.0100461833577085 4726 6080581 SGTC_1256 0570-0116 285 µM -2.33113075756993 0.0165274192316823 no 3300 0.00987323294691295 4731 410638 SGTC_3136 9095672 49.47 µM -2.33406459344161 0.0164170682119231 no 3301 0.00979616995851027 4670 17217380 SGTC_1333 1482-0047 286 µM -2.33695594896157 0.0163089328363122 no 3302 0.00972073735308655 4748 3811116 SGTC_1000 4048-0884 8.67 µM -2.33865990575954 0.0162454917578109 no 3303 0.00967652088025466 4741 13040088 SGTC_511 blebbistatin 171 µM -2.33901681953338 0.0162322300888138 no 3304 0.00966728151424182 4747 3476986 A myosin inhibitor. SGTC_2643 anethole 100 µM -2.39043968382519 0.0144159696869907 no 3305 0.00841410651339741 4756 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3108 9121785 49.47 µM -2.40929528079985 0.0137952921177847 no 3306 0.00799168017975567 4673 17140271 SGTC_1927 st060202 13.8 µM -2.40993261328964 0.0137747218321467 no 3307 0.00797773361334354 4718 688887 SGTC_1934 st074720 32.6 µM -2.41777531887555 0.0135237518712112 no 3308 0.00780785782622067 4704 17250992 SGTC_949 1165-0505 146 µM -2.43809456824925 0.012891810598024 no 3309 0.00738245540877472 4737 6244267 SGTC_474 dl-dihydrosphingosine 5 µM -2.44377832240058 0.012719678918782 no 3310 0.00726717701582826 4745 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1520 flindersine 88 µM -2.46767729074385 0.0120174867693932 no 3311 0.00679964294650253 4745 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.46929073337065 0.0119713164210214 no 3312 0.00676905882977525 4735 551469 SGTC_2441 5730946 39.09 µM -2.4734440448569 0.0118531721403876 no 3313 0.00669088788756912 4760 1774275 SGTC_2121 5257820 149.641 µM -2.4923680622359 0.0113275801649083 no 3314 0.0063447232644539 4759 791256 SGTC_2975 9084847 53.72 µM -2.49891166015777 0.0111506125821002 no 3315 0.00622876804583066 4744 27211724 SGTC_2367 9070478 135.38 µM -2.50664987125197 0.0109444440500662 no 3316 0.00609406877977663 4743 572802 SGTC_2309 7664088 163.95 µM -2.52649627754862 0.0104307726901721 no 3317 0.0057603304652669 4740 704922 SGTC_84 0443-0269 128.823 µM -2.53308109785641 0.010265048430821 no 3318 0.00565323955034133 4751 6150058 SGTC_2107 5363541 170.161 µM -2.53509618102737 0.010214794583358 no 3319 0.00562082279214899 4743 244052 SGTC_2138 5575593 77.673 µM -2.54749980701672 0.00991016287397335 no 3320 0.00542489565601717 4780 762213 SGTC_2463 5473429 200 µM -2.56928384238545 0.00939431708381743 no 3321 0.00509544736764316 4777 5399405 SGTC_2270 7924575 90.91 µM -2.5962343335509 0.00878874758212329 no 3322 0.0047125880454065 4749 1262135 SGTC_2624 nerol 100 µM -2.60154335200189 0.00867357480771129 no 3323 0.00464026673293763 4723 637566 A natural product oil. SGTC_1260 0700-1617 7.75 µM -2.60654088295307 0.00856637094566924 no 3324 0.00457309523178182 4754 2853078 SGTC_1902 st060212 70.5 µM -2.62740595627708 0.00813124492878773 no 3325 0.00430193103750321 4763 688944 SGTC_3093 9117344 49.47 µM -2.63345546867256 0.00800877403193629 no 3326 0.00422604592051426 4777 24824913 SGTC_2919 7978188 46.38 µM -2.64047108897621 0.00786877790475121 no 3327 0.00413954280565037 4753 2980291 SGTC_1330 1469-0054 61.8 µM -2.7073526279664 0.00663859055296169 no 3328 0.00339110876477721 4762 7102664 SGTC_1150 3909-7983 10.9 µM -2.71873604720546 0.00644706135227737 no 3329 0.00327659395668204 4778 23965914 SGTC_1487 3970-0795 2.82 µM -2.72136359044463 0.00640355288291765 no 3330 0.00325066053995935 4789 3765103 SGTC_1606 st000094 49.2 µM -2.73356666170861 0.00620487441538436 no 3331 0.00313262197955031 4772 1242210 SGTC_147 4466-0538 29.23 µM -2.76642042946705 0.00569685708516214 no 3332 0.00283377070692127 4761 6742687 YHR072W ERG7 SGTC_1252 0493-0875 34.8 µM -2.76714605125669 0.00568606626920821 no 3333 0.00282747073112575 4776 3960963 SGTC_2747 doxorubicin 7.63 µM -2.77278029944499 0.00560289423992242 no 3334 0.00277898152128534 4804 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_25 0118-0223 35.662 µM -2.77408627930164 0.00558377047419104 no 3335 0.00276784973413363 4768 5333628 SGTC_406 estrone 100 µM -2.85283481524071 0.00453254127760311 no 3336 0.00216655694941323 4776 5870 A steroid. SGTC_514 4466-0038 2.65 nM -2.88339361970874 0.00417476391893309 no 3337 0.00196707751540923 4692 5722064 SGTC_3014 9081533 49.47 µM -2.90236986597639 0.0039655172679211 no 3338 0.00185175497355346 4789 21367265 SGTC_713 1488-1073 324 µM -2.90261888739448 0.00396283495479738 no 3339 0.00185028335391101 4784 3312542 SGTC_3055 9094636 49.47 µM -2.93204484398771 0.00365708790777941 no 3340 0.00168369059686492 4782 25236176 SGTC_1334 1486-0610 236 µM -2.93517200971656 0.0036258728567897 no 3341 0.00166681417114472 4802 3742339 SGTC_1141 3253-0389 52.6 µM -2.94711906848407 0.00350880841709893 no 3342 0.00160374835879087 4779 5402031 SGTC_974 1326-0144 138 µM -2.99594800693353 0.00306484649891897 no 3343 0.00136796539212561 4800 5411856 SGTC_2150 5556613 200 µM -3.07844386805435 0.00242845275076678 no 3344 0.00104042363145795 4797 743190 SGTC_2522 biochanin a 4.94 µM -3.14420266060584 0.00200963016410396 no 3345 0.000832700302119375 4787 5280373 A possible chelator. SGTC_104 0074-0074 590.992 µM -3.24031678530361 0.00151469150354338 no 3346 0.000596984865887607 4788 3943124 SGTC_2471 5466956 24.79 µM -3.30874218457439 0.00123310576744742 no 3347 0.000468580460933453 4801 724419 SGTC_323 4013-0906 34.3 µM -3.3960687977478 0.000943395501274564 yes 3348 0.000341805873913789 4807 2910086 SGTC_1997 st073024 93.8 µM -3.45986825454758 0.000772826371065177 yes 3349 0.000270219867580815 4807 686268 SGTC_1888 azatryptophan 97.5 µM -3.47900033206815 0.000727509324286745 yes 3350 0.000251643981592003 4798 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1572 epiandrosterone 68.9 µM -3.49992018313196 0.000680769380971588 yes 3351 0.000232698743565216 4799 441302 A steroid. SGTC_133 0724-0033 378.92 µM -3.53613205041529 0.000606356363396954 yes 3352 0.000203015840636587 4793 280309 SGTC_2305 7443522 69.23 µM -3.7542911096916 0.000295371748327684 yes 3353 8.69163715599593e-05 4789 5415886 SGTC_3084 9116877 49.47 µM -3.89953859434248 0.000179202482134443 yes 3354 4.81880872931798e-05 4808 27241325 SGTC_1859 st055998 20 µM -4.32025902572313 3.83357433258702e-05 yes 3355 7.79230792616769e-06 4801 676301 SGTC_2461 5755302 26.15 µM -4.59160159058097 1.31540448326739e-05 yes 3356 2.19928720604675e-06 4810 2788904