SGTCid condition conc unit VPS27|YNR006W.score VPS27|YNR006W.strain.pval VPS27|YNR006W.strain.significant VPS27|YNR006W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1844 rapamycin 4 nM 14.3649199259993 4.28258449562764e-33 yes 1 4.29529707485243e-47 16 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_159 3970-0959 50 µM 13.2834712652957 1.38607082151278e-28 yes 2 1.44347166055248e-40 2 6615653 SGTC_1495 4469-0029 237 µM 10.5002593070096 1.41956052969233e-18 yes 3 4.30715818523583e-26 14 793680 SGTC_1687 st020778 55.3625 µM 9.99834624361149 5.16604569563793e-17 yes 4 7.74816090794867e-24 49 4259299 SGTC_2737 bleomycin 30.5 nM 8.17224716613262 5.82469956020481e-12 yes 5 1.5134879407346e-16 20 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 8.14004140134749 7.00754881495293e-12 yes 6 1.97571377322376e-16 17 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 7.77607086829244 5.39292165837416e-11 yes 7 3.74059036535062e-15 20 442882 SGTC_214 4373-3496 70 µM 7.36521721427547 4.8482285862593e-10 yes 8 8.84293270531761e-14 9 3779166 SGTC_2679 rapamycin 1 nM 6.98253245352149 3.38479456750903e-09 yes 9 1.4495298455907e-12 60 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_150 3970-0969 77.2 µM 6.89118045286069 5.3048273076217e-09 yes 10 2.76656476841753e-12 15 6615640 SGTC_149 3970-0822 46.1 µM 6.65518640002077 1.65013870077538e-08 yes 11 1.41470616345369e-11 26 3114250 YBL034C STU1 SGTC_2360 9040895 200 µM 6.58603797641015 2.2848431410433e-08 yes 12 2.25859164451647e-11 2 4914414 SGTC_748 act1.228 77.9 µM 6.12919678978627 1.8100199252504e-07 yes 13 4.41619128661336e-10 33 4421505 YNR035C ARC35 SGTC_2862 9027634 71.43 µM 6.12218634183397 1.86639784309269e-07 yes 14 4.61499942071988e-10 10 5012562 SGTC_965 1291-5240 308 µM 6.03648952500724 2.70825213003724e-07 yes 15 7.87514853203169e-10 5 2834598 SGTC_2406 ethylparaben 405.7 µM 5.94979906512266 3.9272072215087e-07 yes 16 1.34235935395384e-09 9 8434 A possible steroid mimic. SGTC_168 3970-0862 530.542 µM 5.90620073710493 4.72530742431008e-07 yes 17 1.75043679875298e-09 46 3135186 SGTC_525 k781-2675 26.7 µM 5.88449546342711 5.17875150569565e-07 yes 18 1.99635044868117e-09 27 3651118 YDL195W SEC31 SGTC_524 r073-0010 27.8 µM 5.72358064554189 1.01158314598563e-06 yes 19 5.21510105777328e-09 18 2772106 SGTC_2567 aureobasidin a 60 nM 5.66662085880804 1.27683940286214e-06 yes 20 7.28205573522093e-09 45 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2514 salinomycin 42.74 µM 5.54906852862611 2.05066929463035e-06 yes 21 1.43597799203737e-08 19 23682228 A polyether potassium ionophore. SGTC_2077 5212015 200 µM 5.54294886845751 2.10134869325443e-06 yes 22 1.48709866480623e-08 28 780900 SGTC_377 3970-0964 33.1 µM 5.50023189719154 2.49003770808298e-06 yes 23 1.89646036151108e-08 20 16481235 SGTC_568 1193-0097 7.48 µM 5.49340080255345 2.55825691835639e-06 yes 24 1.97133303254407e-08 68 3646150 SGTC_2582 agaric acid 100 µM 5.45005224068914 3.03472261121107e-06 yes 25 2.51775132997723e-08 192 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1788 fluconazole 20 µM 5.21698454501916 7.44146860010801e-06 yes 26 9.09297135779533e-08 40 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1773 st048542 73.5835 µM 5.11185849361699 1.10218662547366e-05 yes 27 1.59502376591745e-07 26 3237138 SGTC_263 alizarin 107.927 µM 5.04522969655109 1.40843933755941e-05 yes 28 2.2648842900291e-07 34 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2565 isoliquiritigenin 100 µM 4.99460149485708 1.69355540589933e-05 yes 29 2.94786898137481e-07 18 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1911 st060208 74.3 µM 4.94688179297439 2.01182209756123e-05 yes 30 3.77058693797088e-07 15 688783 SGTC_37 0566-0070 1.56 µM 4.88818355876881 2.48137727200097e-05 yes 31 5.08853093579069e-07 13 1626686 SGTC_3145 9085516 49.47 µM 4.79021358467173 3.50392828321524e-05 yes 32 8.33019389493393e-07 12 25236195 SGTC_2067 5224629 34.075 µM 4.69188724490486 4.92276088274862e-05 yes 33 1.35348156212695e-06 11 2835000 SGTC_3123 9126162 49.47 µM 4.6781719031572 5.15923860089089e-05 yes 34 1.44721923865754e-06 9 25239884 SGTC_712 r015-0009 80.6 µM 4.67648555028383 5.18904368498865e-05 yes 35 1.45916576583658e-06 18 6813872 YLR060W FRS1 SGTC_2852 9023854 51.95 µM 4.51758801074921 8.85486080358642e-05 yes 36 3.12740165008779e-06 21 19798528 SGTC_1658 st012944 20 µM 4.51606789559019 8.89953743017025e-05 yes 37 3.14992365005944e-06 58 24207260 SGTC_1239 0337-0584 35.4 µM 4.51148122638879 9.03562901897575e-05 yes 38 3.21882410012282e-06 40 914301 YML130C ERO1 SGTC_1938 st074717 56.4 µM 4.48653203694836 9.81081909394078e-05 yes 39 3.61959181388267e-06 6 17250979 SGTC_1853 st056710 91.2 µM 4.43728002930354 0.000115280061447058 yes 40 4.55513716272116e-06 18 269167 SGTC_1437 4092-1038 11.6 µM 4.41112521487885 0.000125508536524908 yes 41 5.14174130339015e-06 11 3977136 SGTC_376 3970-0862 59.1 µM 4.39134469930364 0.000133802991287967 yes 42 5.63258920946197e-06 15 3135186 SGTC_2841 9004761 38.96 µM 4.36433126765264 0.000145962687787685 yes 43 6.37561129884177e-06 15 2991039 SGTC_2854 9024559 71.43 µM 4.29193411808953 0.000183850237210204 yes 44 8.85617535464051e-06 13 3163529 SGTC_470 aa-861 153 µM 4.23036577427771 0.000223115207362287 yes 45 1.16655813458807e-05 44 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2090 5301565 104.445 µM 4.19202603522105 0.000251383533250563 yes 46 1.38237129273231e-05 41 2056344 SGTC_2110 5483698 200 µM 4.13002576673638 0.000304255560657591 yes 47 1.81361289511486e-05 16 2848765 YHR062C RPP1 SGTC_70 0141-0289 43.283 µM 4.12308144769774 0.000310782380048957 yes 48 1.8691871872059e-05 160 352408 SGTC_365 0121-0052 13.6 µM 4.08221881061763 0.000351902258618397 yes 49 2.23038838712175e-05 53 3101739 SGTC_2170 morpholine 200 µM 4.03994631682757 0.000399719025035756 yes 50 2.67317186554449e-05 9 121171 Reacts with secondary amines. SGTC_2688 kanamycin b 96.69 µM 3.99077689179259 0.000462895424256759 yes 51 3.29286058256407e-05 357 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2172 5754775 163.918 µM 3.95985549262724 0.000507238025838594 yes 52 3.7497565091752e-05 15 2263357 SGTC_2619 obliquin 87.91 µM 3.90164102162951 0.00060156057925688 yes 53 4.77713872067411e-05 147 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3113 9123498 49.47 µM 3.90125153840704 0.000602242936406565 yes 54 4.78483249132142e-05 12 8897275 SGTC_2114 5491910 81.25 µM 3.8861537564617 0.000629251199054616 yes 55 5.09225071430434e-05 15 2849228 SGTC_2283 7944793 200 µM 3.87917890618332 0.000642102322063692 yes 56 5.24048253492998e-05 47 2970533 SGTC_2486 5283202 22.39 µM 3.87295108072336 0.000653781345441642 yes 57 5.37627081479949e-05 35 1377751 SGTC_404 fumagillin 50 µM 3.87002531405824 0.000659335435191338 yes 58 5.44120265087125e-05 24 12015870 A methionine aminopeptidase binder. SGTC_2698 st077697 67.5 µM 3.85947180078869 0.000679733320310937 yes 59 5.68161840039241e-05 19 3154499 SGTC_2878 9043973 25.97 µM 3.81255450556328 0.000777654223573195 yes 60 6.87689428610983e-05 24 6465167 SGTC_751 0833-0568 350 µM 3.72814337973973 0.000987171365060111 yes 61 9.64478142750136e-05 27 6954252 SGTC_3091 9116372 49.47 µM 3.72487287243855 0.000996246250318933 yes 62 9.77068374886888e-05 18 17169793 SGTC_2350 9023895 38.85 µM 3.67997754559746 0.0011288062858464 no 63 0.000116627245970567 39 2997209 SGTC_2593 nobiletin 86.24 µM 3.67897296879572 0.00113194922195263 no 64 0.000117087542001433 36 72344 An anti-infammatory. SGTC_1016 4226-1401 38 µM 3.67835508677715 0.00113388631814714 no 65 0.000117371501029745 24 2901613 SGTC_1571 st070080 73.4 µM 3.64119322031625 0.00125613094685118 no 66 0.000135688682112025 27 4315245 SGTC_1185 1319-0113 81.3 µM 3.61057722835125 0.00136577428311981 no 67 0.000152758156515522 19 4672763 SGTC_1421 4029-0249 71.4 µM 3.5975603567134 0.0014149859001803 no 68 0.000160607985854342 26 2894095 SGTC_2480 5767542 37.17 µM 3.57285585196251 0.00151286090636641 no 69 0.000176554578580895 17 2867358 SGTC_173 1273-0061 2.693 µM 3.48361428410969 0.00192005718132892 no 70 0.000247345933068669 206 2847414 YPL266W DIM1 SGTC_2779 methotrexate 400 µM 3.47165878163841 0.00198159089931372 no 71 0.000258626669363057 40 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2711 st079103 59.1 µM 3.46896373694491 0.00199570701500928 no 72 0.000261234985246549 14 54693780 SGTC_3340 9146634 11.102 µM 3.4487154124797 0.00210471790831339 no 73 0.00028162999951787 26 4907387 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 3.42610697246296 0.00223279569005238 no 74 0.000306149592577977 91 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2467 5474540 200 µM 3.40934909649212 0.00233224299384108 no 75 0.000325590463816691 35 5413519 SGTC_1413 3910-0535 34.4 µM 3.40037779728521 0.00238711438376802 no 76 0.000336464035491873 25 2876951 SGTC_1150 3909-7983 10.9 µM 3.33457508085104 0.00282664042492561 no 77 0.000427149170604186 51 23965914 SGTC_2269 7935389 174.42 µM 3.2957346442726 0.00311912468486469 no 78 0.000490823442217579 46 97605 SGTC_261 5-fluorouridine 15.376 µM 3.27448236582067 0.00329044639172025 no 79 0.000529278728703423 39 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3049 9092223 49.47 µM 3.27295259766652 0.00330309889156868 no 80 0.000532151625360129 48 8623917 SGTC_2512 diallyl trisulfide 49.23 µM 3.26392775756152 0.00337863643098449 no 81 0.000549395893301802 22 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 3.25270148786599 0.00347476478515121 no 82 0.000571567593148087 28 6708784 An antioxidant flavonoid SGTC_407 eburnamonine 100 µM 3.23553255581552 0.00362653513348186 no 83 0.000607080193358094 39 3195 SGTC_1492 4158-0558 28.5 µM 3.23120590380832 0.00366570857801994 no 84 0.000616345526968275 33 3967268 SGTC_2001 4023502 57.655 µM 3.22871404979585 0.00368844168169408 no 85 0.000621740812254572 46 108941 YCR052W RSC6 SGTC_2302 7771753 200 µM 3.22159358679358 0.00375410007172185 no 86 0.000637399106852479 80 2203047 SGTC_2285 7945142 200 µM 3.19739763247822 0.00398511614609341 no 87 0.000693368109713339 49 2970608 SGTC_1231 0242-0792 125 µM 3.18695886985417 0.00408865444009489 no 88 0.000718886095537912 48 3707635 SGTC_1052 3253-3998 198 µM 3.18048187162345 0.0041541015012814 no 89 0.00073515169122104 50 5450317 SGTC_805 3852-0218 479 µM 3.17720099167441 0.00418760957821135 no 90 0.000743519700943827 108 6615355 SGTC_544 k015-0020 52.4 µM 3.16364980142232 0.00432858562578931 no 91 0.000779020733756949 38 3008304 SGTC_1636 st007707 68.9 µM 3.14982269272881 0.004476789730951 no 92 0.000816847893542972 85 403051 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 3.14295193457053 0.0045521051379859 no 93 0.000836266508608374 58 688761 SGTC_1244 0416-0015 52.5 µM 3.14220417600367 0.0045603697391901 no 94 0.000838405305372369 82 96201 SGTC_2856 9022925 19.48 µM 3.13807019542279 0.00460630274246144 no 95 0.000850320721639792 59 4944862 SGTC_2291 7917025 104.35 µM 3.12430072116696 0.00476228908284049 no 96 0.000891141010841831 89 2964612 SGTC_2185 6113692 200 µM 3.12219370619172 0.00478656931460755 no 97 0.00089754393015156 40 874150 SGTC_391 gliotoxin 8.33 µM 3.10469408587313 0.0049925298141018 no 98 0.000952379573443321 93 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_221 trifluoperazine 10.304 µM 3.10096401010903 0.0050374380380448 no 99 0.000964458668080089 267 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1994 st072947 40.9 µM 3.07347986104869 0.00537957341394109 no 100 0.00105788983898967 53 5286565 YDL195W SEC31 SGTC_1176 0848-0131 83.3 µM 3.04239290411451 0.00579132546291939 no 101 0.00117352659353059 56 6769040 SGTC_3279 9140807 49.47 µM 3.02246605047902 0.00606974647988634 no 102 0.00125362102399246 45 45595718 SGTC_332 4112-0506 40.9 µM 3.01406226828627 0.00619067848549351 no 103 0.00128887446733128 58 2790355 SGTC_2068 5226020 147 µM 3.01232719692059 0.0062159106497184 no 104 0.00129626496485375 72 1810509 SGTC_3323 9138564 53.9225 µM 2.9992515030014 0.00640901068334083 no 105 0.00135321898374338 57 43912313 YNL103W MET4 SGTC_1190 1486-1332 13 µM 2.99559106429534 0.00646400999174497 no 106 0.00136956749817633 59 4150046 SGTC_528 3492-0019 172 µM 2.98476586365868 0.00662911329872789 no 107 0.00141897729420418 310 2869262 SGTC_576 1073-0113 22.7 µM 2.97714931501953 0.00674750267248637 no 108 0.00145471138171652 146 5439563 SGTC_462 ag-879 158 µM 2.96718045576758 0.00690527644630555 no 109 0.00150272253238341 78 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1418 3966-3099 2.4 µM 2.91492456495741 0.00778676179630628 no 110 0.00177887262740594 66 740335 SGTC_2003 4023581 200 µM 2.91447732900517 0.00779471489945908 no 111 0.00178142342740937 81 16641307 SGTC_3271 9137798 49.47 µM 2.87802010734029 0.00846754662943797 no 112 0.00200089815574322 38 6498326 SGTC_2151 5563267 85.4165 µM 2.86890766142907 0.00864348222949399 no 113 0.00205946013496453 76 5310824 SGTC_472 calcifediol 10 µM 2.86394181671153 0.00874070185751791 no 114 0.00209202429133292 36 5283731 A vitamin D metabolite. SGTC_1013 4112-3890 241 µM 2.85665755596832 0.00888504504310315 no 115 0.0021406373130994 97 705171 SGTC_3166 9102297 49.47 µM 2.83329702442687 0.00936213647972695 no 116 0.002303527790757 85 25237072 SGTC_2666 tannic acid 100 µM 2.8290900399325 0.00945039693448943 no 117 0.00233402818562555 95 16134267 A thiamine antagonist. SGTC_117 lucigenin 22.078 µM 2.82509112446996 0.00953496589693175 no 118 0.00236335857078634 160 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2438 5259590 200 µM 2.82144507494203 0.00961264833241801 no 119 0.00239039116918599 59 1201127 SGTC_1054 3429-0080 167 µM 2.8006134905188 0.0100671793337829 no 120 0.00255027844464757 86 1162877 SGTC_124 0136-0217 7.121 µM 2.78139319644323 0.0105030753819703 no 121 0.00270630685747134 131 3976905 SGTC_3179 9107801 49.47 µM 2.77289610758143 0.0107009649010268 no 122 0.0027779927770156 64 4818259 SGTC_800 3448-7362 155 µM 2.76932235815707 0.0107851594128673 no 123 0.00280865135258328 310 15991913 SGTC_3237 9133362 49.47 µM 2.7628277685366 0.0109396434784931 no 124 0.00286514974987599 95 43845137 SGTC_828 2074-0507 139 µM 2.75470192032859 0.0111356383984943 no 125 0.00293728142843615 86 X828 SGTC_174 3553-0389 74.3 µM 2.72431958172653 0.0118957569616547 no 126 0.00322170620352564 77 738071 SGTC_373 0844-0104 25.9 µM 2.70949336655172 0.012282753910292 no 127 0.00336930263108356 143 5375804 SGTC_3217 9129673 49.47 µM 2.70871437450582 0.012303385540206 no 128 0.00337722302207001 122 17248312 SGTC_1133 3473-0247 50 µM 2.69603773166394 0.0126433707827488 no 129 0.00350848588957342 134 711311 SGTC_301 4119-0100 24.5 µM 2.68417925053808 0.0129687437447668 no 130 0.00363540560942034 155 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_488 nitrendipine 139 µM 2.67895151304362 0.0131144662486518 no 131 0.0036926543663943 114 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2677 mitomycin C 100 µM 2.67639248085504 0.0131863133812495 no 132 0.003720971977265 57 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2907 7721985 69.9 µM 2.66925957689877 0.0133883739512351 no 133 0.00380093375312465 103 3267881 SGTC_481 bay k-8644 50 µM 2.66558947616578 0.0134933782605099 no 134 0.00384267386094595 87 2303 A calcium channel antagonist. SGTC_1929 genistein trimethyl ether 50.5 µM 2.64911287765582 0.0139735917284439 no 135 0.00403516859015261 78 136420 SGTC_3058 9093861 49.47 µM 2.61472392680028 0.0150235081773155 no 136 0.004464980133515 112 17217477 SGTC_531 3788-1495 174 µM 2.59245701167173 0.015738914076646 no 137 0.00476465448976927 116 2896655 SGTC_2816 7982706 58.44 µM 2.59239005878596 0.0157411084990018 no 138 0.00476558197421883 135 2981853 SGTC_1750 st081859 2.357 µM 2.58653338747233 0.0159340828347433 no 139 0.00484733888149937 321 5291695 SGTC_1860 st056228 74.6 µM 2.58124899810676 0.0161099378784942 no 140 0.00492217746498982 97 688679 SGTC_3249 9135183 49.47 µM 2.57986315351673 0.0161563306510177 no 141 0.00494197370724355 98 4902779 SGTC_2324 6149169 200 µM 2.56983378422482 0.0164954996701982 no 142 0.00508736602670937 86 2888231 SGTC_3259 9138485 49.47 µM 2.56947210956346 0.0165078436463835 no 143 0.00509267951445635 95 17646153 SGTC_2109 5483026 200 µM 2.56544670366296 0.0166457655632536 no 144 0.00515215251097441 123 759335 SGTC_2124 5246320 200 µM 2.5553255642994 0.0169969080046213 no 145 0.00530442599228096 114 579342 SGTC_1297 1068-0111 14.1 µM 2.55446893345198 0.0170269164750341 no 146 0.00531749598192959 87 767057 SGTC_2200 6600604 21.907 µM 2.54789483304838 0.0172587235070972 no 147 0.00541875683718585 145 2904777 SGTC_1476 4112-3294 3.34 µM 2.53958543710864 0.0175555709882122 no 148 0.00554919672126608 100 704369 SGTC_379 3970-0972 5.9 µM 2.53314895626715 0.0177884953566557 no 149 0.00565214521308234 130 2898042 YBL034C STU1 SGTC_1136 pergolide 1.05886 µM 2.52224001883794 0.0181892909578325 no 150 0.00583050560157664 171 47811 A dopamine receptor agonist. SGTC_1000 4048-0884 8.67 µM 2.51245074479584 0.0185554766376787 no 151 0.00599479203850218 122 13040088 SGTC_684 1140-0066 328 µM 2.51018279649323 0.0186412032703396 no 152 0.0060334339513775 155 6813534 SGTC_2743 auranofin 4.32 µM 2.50754755394319 0.018741236570551 no 153 0.00607861109428878 122 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2865 9030313 51.95 µM 2.50131645679295 0.018979586421047 no 154 0.00618662801251086 96 42562754 SGTC_43 0570-0105 72.5 µM 2.49992761646149 0.019033061824153 no 155 0.00621093420099252 265 1114046 YDL195W SEC31 SGTC_1022 4477-0945 21.3 µM 2.49697416683126 0.0191472064343097 no 156 0.00626290406828402 118 4648966 SGTC_718 1130-0073 349 µM 2.49202076324868 0.0193399515448046 no 157 0.00635093059562907 116 6740020 SGTC_3051 9093778 49.47 µM 2.49054323661897 0.0193977628166906 no 158 0.00637739878766188 53 17217378 SGTC_2507 purpurin 79.67 µM 2.48596601595793 0.0195777887858333 no 159 0.00646001514621643 145 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1059 3448-6867 171 µM 2.48317054593982 0.0196884333706509 no 160 0.00651093632459629 99 3934407 SGTC_3196 9111891 49.47 µM 2.4803915141334 0.0197989530926002 no 161 0.00656190964983846 82 18891510 SGTC_2592 piperlongumine 83.33 µM 2.47777467032364 0.019903503661887 no 162 0.00661023037996638 132 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_227 fluconazole 33.516 µM 2.46692163344835 0.020342128658854 no 163 0.0068140089741848 195 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.46538187697129 0.0204050166385759 no 164 0.00684336474888992 88 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1175 0741-0056 27.6 µM 2.46485089388904 0.0204267416519511 no 165 0.00685351392255781 134 765927 SGTC_362 0310-0100 9.03 µM 2.45509123379832 0.020829559801093 no 166 0.00704244183928663 144 790235 SGTC_1579 chlormadinone acetate 49.4 µM 2.44903557680577 0.0210828651776973 no 167 0.00716196495723045 103 45114258 A steroidal progestin. SGTC_1534 6-azauridine 81.6 µM 2.44421761428251 0.0212862556147174 no 168 0.00725833369431015 142 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1062 mesoridazine 14.2 µM 2.44206858922158 0.0213775105121118 no 169 0.00730168591259372 116 4078 A neuroleptic. SGTC_444 curcumin 90.4 µM 2.43327627585224 0.0217543143674316 no 170 0.0074814395225564 129 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_960 1222-0186 7.7 µM 2.43317717471266 0.021758593221707 no 171 0.00748348760970869 140 3126296 SGTC_831 k061-1017 217 µM 2.43059944618459 0.0218701408759866 no 172 0.00753693438608886 239 1240153 SGTC_1889 st059080 5.18 µM 2.42867005905863 0.0219539481207538 no 173 0.0075771581270258 131 176925 Isolated from Daphnopsis sellowiana. SGTC_2186 6124449 200 µM 2.4198423767596 0.0223408647679873 no 174 0.00776361798481261 125 3834182 YLR033W RSC58 SGTC_3224 9130643 49.47 µM 2.41950822903913 0.0223556227149355 no 175 0.00777075454130261 148 17644395 SGTC_2322 7413319 38.22 µM 2.41701200340202 0.0224661312427239 no 176 0.00782425053973866 316 1840400 SGTC_2831 7999036 19.48 µM 2.41492299893501 0.0225589657257014 no 177 0.00786926824050745 188 2988270 SGTC_1524 corynanthine 62.1 µM 2.41222424414298 0.0226793758814986 no 178 0.00792776315831141 126 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1278 0874-0585 172 µM 2.39996938356209 0.0232329865951636 no 179 0.00819822159053329 116 766306 SGTC_900 1112-0045 141 µM 2.39798399016166 0.0233237384670077 no 180 0.00824279288525982 107 56211 YIL048W NEO1 SGTC_1985 st071382 65.5 µM 2.39002007627569 0.0236907712138395 no 181 0.00842372591375769 121 6123237 SGTC_562 3772-2733 112 µM 2.38038353415821 0.0241413726254643 no 182 0.00864731354122171 210 2876874 YIL048W NEO1 SGTC_670 4204-0025 119 µM 2.37290372017475 0.0244960695879582 no 183 0.0088244318711373 149 719039 SGTC_2775 cyproheptadine 69.59 µM 2.36193111302541 0.0250243041533292 no 184 0.0090900100193197 113 2913 A selective serotonin reuptake inhibitor. SGTC_2792 7535235 81.82 µM 2.35627333197916 0.0253003871035471 no 185 0.00922966472119847 142 1281891 SGTC_1529 apigenin 74 µM 2.33804795924259 0.0262071378297336 no 186 0.00969238019276364 176 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1604 st002052 72.4 µM 2.33108352658501 0.0265607348828897 no 187 0.00987447787946164 132 6254834 YHR062C RPP1 SGTC_364 0083-0097 67.7 µM 2.32836987305649 0.0266995869814539 no 188 0.00994623598007575 140 5207356 SGTC_206 4546-0025 72.014 µM 2.32237695790493 0.027008380926099 no 189 0.0101063234805852 218 6620745 YIL048W NEO1 SGTC_1078 idebenone 36.1 µM 2.31957859591743 0.0271535883926752 no 190 0.0101818424215307 214 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1720 st037298 9.481 µM 2.30585151211969 0.0278753554475541 no 191 0.010559465378071 163 597396 SGTC_2828 7998861 71.43 µM 2.30208744436069 0.0280760383986794 no 192 0.0106651206702286 109 2988188 SGTC_2404 5161160 200 µM 2.30165114551408 0.0280993774782186 no 193 0.0106774266808564 154 2831543 SGTC_26 0302-0163 425.158 µM 2.29635358563985 0.028384052721371 no 194 0.0108278362647006 110 3100915 SGTC_459 nigericin 15.3 µM 2.28281940111734 0.0291222533219453 no 195 0.0112205043307086 200 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_977 1348-1378 135 µM 2.28259463192371 0.0291346463860156 no 196 0.0112271287312512 159 X977 SGTC_1799 st045822 46.1415 µM 2.2738359910391 0.0296209928567615 no 197 0.0114879247017778 124 3674992 SGTC_2889 9059656 51.95 µM 2.26909987237265 0.0298867728235271 no 198 0.0116311265705489 119 3949838 SGTC_3210 9128157 49.47 µM 2.2672113659425 0.029993301603685 no 199 0.0116886584185856 206 17590849 SGTC_1851 st056236 18.9 µM 2.26424536505791 0.0301612462677174 no 200 0.0117795139147146 149 5393171 SGTC_493 zm226600 134 µM 2.25708452858381 0.0305699311775519 no 201 0.0120013967176044 162 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3087 9117406 49.47 µM 2.25356464816692 0.0307724938017416 no 202 0.0121117847109988 145 42546093 SGTC_1152 3909-8331 15.9 µM 2.25195022385821 0.0308657719762989 no 203 0.0121627088769241 136 16001939 SGTC_375 3970-0961 9.27 µM 2.24720735229229 0.0311411601142958 no 204 0.0123133892649072 162 2898222 SGTC_2676 harmalol 100 µM 2.23762106380015 0.0317039819166974 no 205 0.0126228883777954 140 5459187 A monoamine oxidase inhibitor SGTC_300 r073-0011 5.04 µM 2.23637233940343 0.0317779108550565 no 206 0.0126636957367663 170 2735780 SGTC_1189 1431-2119 7.28 µM 2.23406985859139 0.0319145993341895 no 207 0.0127392384400971 213 3107275 SGTC_2596 sinensetin 100 µM 2.23151802298964 0.03206665790289 no 208 0.0128234175155356 171 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2629 bisabolol 100 µM 2.22040248153747 0.0327360034999393 no 209 0.0131957293781628 191 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3326 9140064 16.379 µM 2.21684127301649 0.0329528702497862 no 210 0.0133169700096422 153 1868434 SGTC_2293 7624732 200 µM 2.21227387486427 0.0332327426042376 no 211 0.0134738735503158 167 894453 SGTC_526 4469-0568 170 µM 2.20829266376263 0.033478290058761 no 212 0.0136119392030299 182 2901964 SGTC_1972 st070201 17.4 µM 2.20395948190361 0.0337472414010433 no 213 0.0137635968653313 153 2829099 SGTC_1224 0823-0416 294 µM 2.2037992730841 0.0337572192014929 no 214 0.0137692318667646 152 3598164 SGTC_953 1188-0045 9.7 µM 2.20335550963737 0.0337848694494092 no 215 0.013784850684953 187 6144426 SGTC_2614 arthonioic acid 13.39 µM 2.19759047474561 0.0341457767001974 no 216 0.0139891513133573 153 6710684 SGTC_1366 1683-0113 21.9 µM 2.19212236566803 0.034491018712586 no 217 0.014185336102337 139 708623 SGTC_1509 1326-1131 80 µM 2.18807583305752 0.0347483482730936 no 218 0.0143320394746017 134 768313 SGTC_2307 7538926 6.34 µM 2.18708347742051 0.034811694888098 no 219 0.0143682152894052 214 96582 SGTC_52 0329-0193 875 nM 2.17194894408626 0.0357896055993414 no 220 0.0149297570751729 179 3739292 SGTC_1066 ketoconazole 628 nM 2.16540231352796 0.0362195317853477 no 221 0.0151784445199017 185 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1552 6-methylflavone 10.6 µM 2.16462385079194 0.0362709346164266 no 222 0.0152082514780356 120 689013 SGTC_750 4073-0104 132 µM 2.15869608837129 0.036664313605637 no 223 0.0154368762297511 130 22330957 SGTC_2176 5809774 33.9695 µM 2.15661284234579 0.0368033883000132 no 224 0.0155179215313472 153 2870539 SGTC_2978 9011784 42.97 µM 2.14793280043748 0.037387506759609 no 225 0.0158595471162817 232 2994934 SGTC_1429 4049-0205 9.46 µM 2.14557217636241 0.037547666758703 no 226 0.0159535636336095 177 22774478 SGTC_2483 5729050 27.16 µM 2.14488369921946 0.0375944828784791 no 227 0.0159810734308545 221 2865180 SGTC_3165 9101544 49.47 µM 2.14312573438884 0.0377142398979934 no 228 0.0160515017814776 165 5002184 SGTC_50 0929-0078 56.389 µM 2.1373681627159 0.038108641974975 no 229 0.0162840293965207 214 1377751 SGTC_1932 st074806 40.9 µM 2.13665694119212 0.0381575942965189 no 230 0.0163129523109028 194 17251235 SGTC_2638 epoxomicin 18 µM 2.13467535658454 0.0382942543693054 no 231 0.0163937686539206 186 9915668 A protesome inhibitor. SGTC_1780 st038448 24.544 µM 2.13322035546155 0.0383948524609119 no 232 0.0164533270337772 196 728868 YDL195W SEC31 SGTC_665 3914-0008 307 µM 2.12844490884568 0.0387265393642529 no 233 0.0166501065231402 195 1069549 SGTC_3061 glucosamine 200 µM 2.12818278360221 0.0387448130989877 no 234 0.016660965846219 136 91431 and experimental redox chemotherapeutic SGTC_1265 0819-1001 68.8 µM 2.12573411215505 0.0389158586939599 no 235 0.0167627024459511 174 3106768 SGTC_1754 st042065 16.137 µM 2.11848117808665 0.0394261045634765 no 236 0.0170671686467536 402 1126236 YIL048W NEO1 SGTC_1329 1447-1697 50.6 µM 2.10664793465316 0.040270249129611 no 237 0.0175740542065827 194 2840515 SGTC_2144 5628481 200 µM 2.10359761410586 0.0404902123967453 no 238 0.0177067811301309 186 2818399 SGTC_2091 4-phenylthiadiazole 200 µM 2.09217066656109 0.0413229131086232 no 239 0.0182116257519444 207 270010 SGTC_138 0850-0259 40.9225 µM 2.09177513275565 0.0413519830252077 no 240 0.0182293179267615 408 6813004 SGTC_2113 5491891 107.031 µM 2.09003948277633 0.0414797413259117 no 241 0.0183071265649155 211 789979 SGTC_607 4491-0986 66.8 µM 2.0856076712482 0.0418074109770448 no 242 0.0185070879500601 205 698981 YDR232W HEM1 SGTC_1034 k072-0165 12.7 µM 2.08482805453297 0.0418652688058472 no 243 0.018542455587023 218 5835461 SGTC_1990 st072050 59.8 µM 2.08286417035233 0.042011302272364 no 244 0.0186318031717613 170 17233948 SGTC_833 3852-0053 558 µM 2.07809802779525 0.0423674253526752 no 245 0.0188501656407489 198 3123681 SGTC_2093 5331342 194.4 µM 2.07089445251665 0.0429103024985538 no 246 0.0191843303565536 185 33839 SGTC_902 1120-0002 2.07 µM 2.07012993462592 0.0429682467077621 no 247 0.0192200891640363 238 3280475 SGTC_1333 1482-0047 286 µM 2.06640383336991 0.0432515602941147 no 248 0.0193951821423592 225 3811116 SGTC_2244 6635614 200 µM 2.06615020577876 0.0432708995404735 no 249 0.0194071494447416 97 836499 SGTC_1285 0929-0069 65.5 µM 2.06200956717827 0.0435876142469526 no 250 0.0196034125657972 199 1206237 SGTC_195 4234-0266 16.654 µM 2.05808943299696 0.043889184225435 no 251 0.0197907745957984 240 2303354 SGTC_1035 k081-0041 55.2 µM 2.05425936225809 0.0441854489074516 no 252 0.0199752978352613 210 731709 SGTC_1164 k060-0068 93.7 µM 2.05095921036395 0.0444420142684908 no 253 0.020135459587926 231 5963676 SGTC_2588 indole-3-carbinol 100 µM 2.04950116240371 0.0445557496942805 no 254 0.0202065671470921 266 3712 Induces cell cycle arrest. SGTC_44 0929-0055 61.211 µM 2.04498795818061 0.0449092902624422 no 255 0.0204280226504128 193 1379590 SGTC_102 gallobenzophenone 83.616 µM 2.04463774826753 0.0449368180083947 no 256 0.0204452925384154 224 70837 SGTC_626 0214-0009 33 µM 2.03895277629107 0.0453855797961341 no 257 0.0207273704357246 197 3437874 SGTC_1007 4101-0031 70 µM 2.03519638569853 0.0456840754532834 no 258 0.0209155582960353 202 1146276 SGTC_1740 st038286 13.222 µM 2.03376646638783 0.0457981156104257 no 259 0.0209875735309993 228 716786 SGTC_316 k060-0003 58.6 µM 2.02484711621492 0.0465146329416714 no 260 0.0214415326502327 190 6152314 SGTC_1719 st032227 49.2 µM 2.02484310694804 0.0465149570291518 no 261 0.0214417385575772 211 3125804 SGTC_210 3551-0445 56.827 µM 2.02470749050232 0.0465259205976677 no 262 0.0214487045118897 234 2865180 YOR207C RET1 SGTC_1101 ebselen 5.29 µM 2.02313203930622 0.0466534360146805 no 263 0.021529768041511 213 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_939 1165-0479 45.3 µM 2.02100567658559 0.0468259861442227 no 264 0.0216395887344588 251 1377347 SGTC_565 1418-0001 44.5 µM 2.01967970600483 0.0469338449239169 no 265 0.0217083107345003 243 2862145 SGTC_418 lividomycin a 100 µM 2.01873097194687 0.0470111402626382 no 266 0.0217575945138237 186 72394 An antibiotic. SGTC_259 usnic acid 108.925 µM 2.0166008235863 0.0471850597721915 no 267 0.0218685935056945 222 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3159 9100096 49.47 µM 2.01644185442965 0.0471980597279131 no 268 0.0218768963032656 216 25236875 SGTC_1220 1838-0075 193 µM 2.01398098714714 0.0473996675068066 no 269 0.0220057648445056 211 5529645 SGTC_1798 st045719 60.953 µM 2.01292430004991 0.0474864486207643 no 270 0.0220612968620887 150 3980186 SGTC_2739 tacrine 100.86 µM 2.01071671770678 0.0476681584844244 no 271 0.0221776935917192 188 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1884 5633444 25 µM 2.01046318834257 0.0476890625196254 no 272 0.0221910942676303 262 5724239 SGTC_506 n9-isopropylolomoucine 153 µM 2.00702115210538 0.0479735927704271 no 273 0.0223737053971342 201 6610355 SGTC_1831 st055328 12 µM 2.0023997624446 0.0483577474430288 no 274 0.0226208770078741 226 1103068 SGTC_2065 5221596 34.26 µM 2.00224673430729 0.0483705099251546 no 275 0.0226291008217999 223 788581 SGTC_648 0375-0473 33.3 µM 2.00047449606636 0.0485185101945272 no 276 0.022724525599944 240 1713139 SGTC_438 sphingosine 6.67 µM 2.00020759089964 0.0485408308832334 no 277 0.0227389262413127 178 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_401 neomycin 50 µM 1.99810828972318 0.0487166771778081 no 278 0.0228524606075272 182 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1057 3448-5381 134 µM 1.98396582269863 0.0499146161792304 no 279 0.0236298250554937 232 5497911 SGTC_2685 mycophenolic acid 18.85 µM 1.98313910793126 0.0499853635846079 no 280 0.0236759466419919 161 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1954 st077032 68.9 µM 1.98310178772063 0.0499885592052334 no 281 0.0236780304836302 202 698907 SGTC_1899 st063254 59.6 µM 1.97245910590601 0.0509065287709608 no 282 0.024278610115113 185 3093813 SGTC_1864 st057645 30.4 µM 1.970862837996 0.0510453627062325 no 283 0.0243697833982891 165 688666 SGTC_123 0083-0120 66.675 µM 1.96390605812069 0.0516539441354585 no 284 0.0247704935919202 261 16001701 SGTC_1334 1486-0610 236 µM 1.96046551660055 0.0519570483916877 no 285 0.0249707023268857 233 3742339 SGTC_25 0118-0223 35.662 µM 1.95821409371221 0.0521561576668551 no 286 0.0251024480230905 221 5333628 SGTC_518 1021-0119 62.6 µM 1.95808332641772 0.0521677409419651 no 287 0.0251101179543192 270 1097762 SGTC_2732 terfenadine 20 µM 1.95628771094941 0.0523270020405218 no 288 0.0252156355150221 169 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2407 paclitaxel 400 µM 1.95624641008935 0.0523306697338404 no 289 0.0252180668838087 275 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2752 diclazuril 33.15 µM 1.93896333253346 0.0538834819613572 no 290 0.026252901589378 404 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2917 7979103 53.79 µM 1.93744189001554 0.0540219061876798 no 291 0.0263456751080785 287 2980565 SGTC_3150 9097574 49.47 µM 1.9274485502642 0.0549381314830599 no 292 0.0269618770301738 186 17217476 SGTC_732 3970-1727 52.7 µM 1.91856195078683 0.0557631628321201 no 293 0.0275198974140047 197 1275699 SGTC_744 1594-0068 283 µM 1.91720052692781 0.055890416512971 no 294 0.027606230580165 296 668392 SGTC_2475 5812728 15.03 µM 1.90438609556417 0.0570994499272001 no 295 0.0284299593655011 264 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1442 4112-3290 3 µM 1.90293935981747 0.0572372321760046 no 296 0.0285242291664301 254 704353 SGTC_1979 st071809 45.3 µM 1.89441260710645 0.0580546140914455 no 297 0.0290851321696392 228 4976333 SGTC_2385 9074692 200 µM 1.88951530178488 0.0585282046683054 no 298 0.0294114071880727 291 17046906 SGTC_2508 celastrol 40.54 µM 1.88685973700296 0.0587862747152184 no 299 0.0295895969037814 207 122724 Celastrol is a natural product and antioxidant. SGTC_3181 9108277 49.47 µM 1.88592880889238 0.0588769542140667 no 300 0.0296522743666758 243 17097298 SGTC_2773 thioridazine 9.09 µM 1.88205910900863 0.0592550693796358 no 301 0.029913995267623 229 5452 An antipsychotic. SGTC_2443 5493264 126.67 µM 1.88127984068233 0.0593314428918229 no 302 0.0299669309142407 238 5340055 SGTC_3162 9099653 49.47 µM 1.86475960833598 0.0609687650893008 no 303 0.031107553654626 197 25237511 SGTC_3013 9080133 71.4286 µM 1.86329694036514 0.0611154159336301 no 304 0.0312102501927734 292 17050193 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.86142013235177 0.0613039931804467 no 305 0.0313424348571766 279 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2652 actinonin 100 µM 1.86107356481706 0.0613388651420855 no 306 0.0313668943713612 184 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_567 1080-0542 68.4 µM 1.84768669551075 0.0626977622308647 no 307 0.0323238398760739 224 5950415 SGTC_3027 9089541 49.47 µM 1.84695431624442 0.0627727773862053 no 308 0.0323768807858397 279 9943819 SGTC_3300 9124615 50.48 µM 1.84683136625659 0.0627853775950944 no 309 0.0323857921965202 286 24824903 SGTC_2897 9048598 12.99 µM 1.8442245831341 0.0630529910924219 no 310 0.0325752085679403 224 6467404 SGTC_1392 3455-1037 33.9 µM 1.84414700545028 0.0630609688434868 no 311 0.0325808595573786 258 981132 SGTC_1590 st077108 57.8 µM 1.84309782242853 0.0631689394846552 no 312 0.0326573646141322 211 5489485 SGTC_446 go6976 132 µM 1.84089694601259 0.0633958977008807 no 313 0.0328183310224009 218 3501 A protein kinase C inhibitor. SGTC_1216 1165-0504 9.65 µM 1.83833408171362 0.0636609840844833 no 314 0.0330065959723005 279 6304004 SGTC_592 k241-0073 46.5 µM 1.83531464099432 0.0639744014723684 no 315 0.0332295414846345 274 4230158 SGTC_1324 1418-0026 34.4 µM 1.83427639848122 0.0640824476379072 no 316 0.0333064878745774 288 1372513 SGTC_66 0109-0187 42.4 µM 1.83190184656043 0.0643300919629205 no 317 0.0334830227037775 288 759417 SGTC_990 3985-0011 41.3 µM 1.8297620602272 0.0645538888214437 no 318 0.0336427631606299 231 5399565 YGL099W LSG1 SGTC_395 anisomycin 6.25 µM 1.82715086284145 0.0648278085986002 no 319 0.0338385447661132 207 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2303 7774051 200 µM 1.82681387327834 0.064863225122316 no 320 0.0338638796220135 265 2953184 SGTC_2462 5162487 171.77 µM 1.8207609241475 0.0655019319814223 no 321 0.0343216032968512 261 2259986 SGTC_69 0096-0274 206.684 µM 1.8196879764034 0.0656156565662333 no 322 0.0344032676909198 361 6741392 SGTC_2457 5731572 11.68 µM 1.8166529450195 0.0659381766754101 no 323 0.0346351355145915 216 2865357 SGTC_402 epigallocatechin gallate 10 µM 1.81189502023159 0.0664462521398968 no 324 0.0350012095038964 309 65064 An antioxidant. SGTC_2951 9072950 58.06 µM 1.81157617344413 0.0664804082901687 no 325 0.0350258546319811 301 16488155 SGTC_3148 9097893 49.47 µM 1.81113670669094 0.0665275080127272 no 326 0.0350598463693336 305 17174100 SGTC_2047 4141938 200 µM 1.80447287698629 0.0672448716044659 no 327 0.0355786037036041 234 3807862 SGTC_887 0885-0007 9.62 µM 1.80354475861848 0.0673452565599747 no 328 0.0356513513764038 308 5719458 SGTC_631 k072-0230 41.5 µM 1.79855490055264 0.0678869445557474 no 329 0.0360445584173472 296 5773147 SGTC_937 3122-0005 46.7 µM 1.79814522317191 0.0679315672676788 no 330 0.0360769986688991 304 759535 SGTC_2286 7945697 125 µM 1.79632677268142 0.0681299092225184 no 331 0.036221281170807 333 1245733 SGTC_2424 5537928 59.2 µM 1.79609780114419 0.0681549152514167 no 332 0.0362394820497428 327 5382802 SGTC_157 1348-1695 65.819 µM 1.79416344409036 0.0683664496020819 no 333 0.0363935425086211 384 5380510 SGTC_2080 5212524 12.4 µM 1.78493833819761 0.0693822496244133 no 334 0.0371356595944893 250 260183 SGTC_3336 9143619 71.43 µM 1.78371116122351 0.0695182487627477 no 335 0.037235305789769 308 45595730 SGTC_2133 5320837 200 µM 1.78280021598501 0.069619334904551 no 336 0.0373094153024803 287 2841355 SGTC_2399 5884133 200 µM 1.77347083648864 0.0706611256923528 no 337 0.0380753601120826 344 722445 SGTC_119 0121-0043 24.815 µM 1.76687175707534 0.0714052351467763 no 338 0.0386248539520299 503 1092378 SGTC_1635 st007035 42.4 µM 1.76514571420323 0.0716008518075535 no 339 0.0387696396947122 544 3716403 SGTC_1205 4161-2785 76 µM 1.75806897581091 0.0724071767815957 no 340 0.0393678868897117 280 3498106 SGTC_584 0986-0246 15.4 µM 1.75777821314897 0.0724404545254365 no 341 0.0393926268838946 314 53315 YDR232W HEM1 SGTC_21 0849-0113 22.993 µM 1.74940644239763 0.0734036360500117 no 342 0.0401103940253849 328 1560156 SGTC_597 k018-0003 82.8 µM 1.74456506349635 0.0739650948815826 no 343 0.0405303033173229 298 6786234 SGTC_3289 9119912 71.43 µM 1.74259103107515 0.074194964594368 no 344 0.040702538905531 311 17014829 SGTC_2842 9000675 19.48 µM 1.73697896316761 0.0748514524948111 no 345 0.0411954420780359 301 2989072 SGTC_1419 3993-2473 62.6 µM 1.73548253294489 0.0750272479068563 no 346 0.0413276863488251 290 704026 SGTC_1605 st000082 49.1 µM 1.73481112810324 0.0751062244689758 no 347 0.041387132241892 286 1114022 SGTC_603 3794-0023 45.9 µM 1.73030281435543 0.0756381750037237 no 348 0.0417880934976115 272 3802260 SGTC_2326 6164455 177.58 µM 1.72882910247428 0.0758126841108172 no 349 0.0419198429500111 302 2888790 SGTC_920 mycophenolic acid 780.421 nM 1.72316609270702 0.0764861215754262 no 350 0.0424292467634782 319 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1218 1348-1416 30.7 µM 1.72083012559318 0.0767652336753318 no 351 0.0426408270296414 301 6787668 SGTC_2160 5660466 132.927 µM 1.71930325775635 0.0769480889789056 no 352 0.0427795835431542 290 2859134 SGTC_913 3487-1245 167 µM 1.71849759529273 0.0770447071978795 no 353 0.0428529463476669 332 4016153 SGTC_1483 3453-0561 55.9 µM 1.71744015383199 0.0771716596338086 no 354 0.0429493901600665 353 4546991 SGTC_3355 9151058 44.0485 µM 1.71559649084657 0.0773933829212646 no 355 0.0431179606148421 301 17015728 SGTC_691 1548-0686 185 µM 1.71534505513128 0.0774236586323699 no 356 0.0431409913316215 361 46495133 SGTC_2009 4012297 12.05 µM 1.71522884000482 0.077437655290606 no 357 0.0431516396270285 337 45595307 SGTC_866 0495-0101 262 µM 1.71332066454945 0.0776677460580686 no 358 0.0433267813695417 289 635694 SGTC_1547 harmine 94.2 µM 1.70974602426959 0.0781001780733475 no 359 0.0436564239996358 401 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_637 1181-0519 7.26 µM 1.70187738867313 0.0790584960341529 no 360 0.0443891776515462 450 6252091 YGR060W ERG25 SGTC_372 0155-0182 15.9 µM 1.70034028628615 0.0792467344867347 no 361 0.0445334684029512 335 771486 SGTC_297 0986-0032 24 µM 1.70023087500055 0.0792601462662331 no 362 0.0445437534385418 278 2847425 SGTC_3299 9121982 43.1275 µM 1.69982094105099 0.0793104117906305 no 363 0.0445823056507631 334 17594604 YPL160W CDC60 SGTC_2710 st078562 53.7235 µM 1.69471909496019 0.0799380135408172 no 364 0.0450643607789281 303 17250908 SGTC_2662 daunorubicin 22.37 µM 1.69415067286192 0.0800081696449489 no 365 0.0451183276833479 283 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2141 5621638 7.665 µM 1.69347405393244 0.0800917403541113 no 366 0.045182634753092 307 2856238 SGTC_1359 1582-0056 520 nM 1.69178067822393 0.0803011821806756 no 367 0.0453438994775101 362 3661189 SGTC_3121 9125696 49.47 µM 1.68509506100302 0.0811321236152912 no 368 0.0459851162051886 249 1235365 SGTC_710 3448-4187 58 µM 1.68084561532979 0.0816636410105981 no 369 0.0463964529006549 441 3946412 SGTC_993 3909-8757 62.7 µM 1.6771344162978 0.0821299787464635 no 370 0.0467581000701707 284 4288324 YLR208W SEC13 SGTC_1900 st060200 72.8 µM 1.67290553299253 0.0826638091812559 no 371 0.0471729472029918 336 688945 SGTC_1240 0356-0016 42.1 µM 1.67268147908663 0.0826921651581911 no 372 0.0471950085944497 341 4305613 SGTC_1698 5-fluorocytosine 1.055 µM 1.66418843538669 0.0837724395203557 no 373 0.0480373892048773 307 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1933 st074711 15.9 µM 1.66024346677915 0.0842778114929609 no 374 0.0484327417759131 368 17250958 SGTC_610 4215-0184 155 µM 1.65956840734162 0.0843645190713822 no 375 0.0485006541584861 356 5605015 SGTC_1330 1469-0054 61.8 µM 1.65705769758404 0.084687593088859 no 376 0.0487539052873306 319 7102664 SGTC_892 0929-0076 29 µM 1.65218434560623 0.0853173350187876 no 377 0.0492484883422459 413 5751038 SGTC_2661 dactinomycin 12.96 µM 1.64789552156577 0.0858744398195857 no 378 0.0496870562895431 371 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3354 9151612 71.43 µM 1.63873107378693 0.0870739901658364 no 379 0.0506346397571641 365 27261949 SGTC_696 1560-0013 611 µM 1.63584154695149 0.0874547883156515 no 380 0.0509363770849559 352 1650269 SGTC_1149 3909-7961 23.3 µM 1.63431700420145 0.0876562013860746 no 381 0.0510961525231636 344 735261 SGTC_2722 naftopidil 47.16 µM 1.62858338699612 0.0884167899086045 no 382 0.0517006217475728 345 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2767 sibutramine 71.45 µM 1.62207441051586 0.089286180682341 no 383 0.0523937082748777 356 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1902 st060212 70.5 µM 1.61580239646304 0.090129922552517 no 384 0.0530685216350123 368 688944 SGTC_20 0481-0013 4.944 µM 1.61461993154767 0.0902896549654482 no 385 0.0531965132121843 368 182045 SGTC_2912 7964298 10.93 µM 1.61449594003809 0.0903064164396113 no 386 0.0532099483821906 438 2975850 SGTC_2746 daunorubicin 9.88 µM 1.61426903651053 0.0903370957947391 no 387 0.0532345416072133 207 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3190 9110366 49.47 µM 1.61133004782613 0.0907351726059683 no 388 0.0535539024645581 291 17123768 SGTC_1067 clotrimazole 1.36 µM 1.60898145744586 0.091054216462402 no 389 0.053810198111226 394 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2049 5262831 67.185 µM 1.60469121539985 0.0916391706514607 no 390 0.054280888065131 363 763417 SGTC_2947 9072639 7.68 µM 1.60194258414763 0.0920153941174293 no 391 0.0545841532926442 420 16488146 SGTC_2696 st077691 74.316 µM 1.60019893678186 0.0922546509207097 no 392 0.0547772289772668 344 757133 SGTC_1602 st001878 87.6 µM 1.59775139160757 0.0925912703389968 no 393 0.0550491582209822 338 595405 YLR310C CDC25 SGTC_1253 0550-0034 176 µM 1.59636096346063 0.092782905007473 no 394 0.0552041131621755 358 5969915 SGTC_2440 5628896 157.78 µM 1.59472203897521 0.0930091649081193 no 395 0.0553872037055197 338 5522048 SGTC_946 3434-1334 87.4 µM 1.58902206964459 0.0937992436987398 no 396 0.0560277050997164 379 4047976 SGTC_2817 7995342 71.43 µM 1.58873654075931 0.0938389510644461 no 397 0.0560599427794689 323 18879975 SGTC_3106 9121286 49.47 µM 1.58297926246051 0.0946422420616475 no 398 0.0567130955419978 320 15943471 SGTC_2103 5378138 10 µM 1.57857753364404 0.0952598090319208 no 399 0.0572164955811713 412 244142 SGTC_2188 6126565 140.678 µM 1.57774731108901 0.0953766219387012 no 400 0.057311836300761 299 874518 SGTC_2802 7925815 54.55 µM 1.57728671584304 0.0954414734801018 no 401 0.0573647838179922 417 1262923 SGTC_2006 4011487 200 µM 1.57677975374816 0.0955128909635189 no 402 0.0574231059012454 434 45595294 SGTC_2533 agelasine 13.65 µM 1.57464423702242 0.0958141603129151 no 403 0.0576692929295796 415 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_29 0299-0004 12.984 µM 1.57032631016646 0.0964254490207016 no 404 0.0581696081370009 280 16871 A napthoquinone isolated from Swertia calycina. SGTC_1768 st044301 37.178 µM 1.56621683584301 0.0970098840978369 no 405 0.0586489312981641 393 3931349 SGTC_313 3474-0040 5.03 µM 1.56590190120078 0.0970547800417418 no 406 0.0586857923553239 462 1043375 YIL048W NEO1 SGTC_3081 9117243 49.47 µM 1.56585813598434 0.0970610202594992 no 407 0.058690916228882 361 45595589 SGTC_1384 3089-0840 101 µM 1.56536153462756 0.0971318482764505 no 408 0.0587490811247342 343 1069836 SGTC_2002 4023503 131 µM 1.56514413321171 0.0971628671970369 no 409 0.0587745587019363 489 4736863 YCR052W RSC6 SGTC_2699 st077704 54.6 µM 1.55459536415646 0.0986767161630987 no 410 0.0600212342803933 395 645852 SGTC_447 ml7 120 µM 1.55434338241764 0.0987130878777411 no 411 0.0600512652921872 392 4216 Selective myosin light chain kinase inhibitor. SGTC_2402 5553605 200 µM 1.55362735684487 0.0988164944662946 no 412 0.0601366649517996 406 6758546 SGTC_3329 9141233 27.5565 µM 1.55220614729416 0.0990219766899087 no 413 0.0603064528415157 361 4909101 YNL103W MET4 SGTC_535 2293-4129 48.2 µM 1.55045433801846 0.099275687742099 no 414 0.0605162525466361 490 396118 YIL048W NEO1 SGTC_1792 st045773 43.6 µM 1.54926289113566 0.0994485139714294 no 415 0.0606592682449376 392 2919270 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.54685058006835 0.0997991067705438 no 416 0.0609496401385416 290 77254 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.54634884195523 0.0998721400749262 no 417 0.0610101710667764 384 6312947 SGTC_1702 st027038 51 µM 1.54413308319705 0.100195134139953 no 418 0.0612780478505576 418 5521182 SGTC_2149 5554786 194.827 µM 1.54281551197401 0.100387559396752 no 419 0.0614377723497932 445 745063 YPR165W RHO1 SGTC_1132 3456-3614 2.5 µM 1.5425765344393 0.100422489847152 no 420 0.0614667775609979 503 3125502 SGTC_1540 guanosine 70.6 µM 1.54072848056133 0.100692912474442 no 421 0.0616914410868552 346 6802 Guanosine is a purine nucleoside SGTC_1222 0366-0074 1.18 µM 1.54065988888997 0.100702959591076 no 422 0.0616997919366058 403 286520 SGTC_1998 st075797 76.8 µM 1.53096008128929 0.102131132328733 no 423 0.062889629371482 443 24208315 SGTC_773 4358-1457 44.6 µM 1.53056900877016 0.102189020214814 no 424 0.0629379730003867 466 1186886 SGTC_3213 9129884 49.47 µM 1.52941335781706 0.102360223076857 no 425 0.0630810015261013 346 17190742 SGTC_2583 asiatic acid 100 µM 1.52314212785307 0.103292906710181 no 426 0.0638615755305745 378 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1553 gossypol 38.6 µM 1.51917228803488 0.103886498238081 no 427 0.0643595673891983 266 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2053 5265679 138 µM 1.51862143423153 0.103969059898107 no 428 0.0644289063595035 434 764595 SGTC_1124 fisetin 1.16336 µM 1.51592809731059 0.104373420839744 no 429 0.064768767355198 387 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_451 chloral hydrate 100 µM 1.51521000860531 0.104481422410574 no 430 0.0648596146323775 502 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3001 9076041 71.4286 µM 1.51404506970873 0.10465680307675 no 431 0.0650072044855152 405 16004211 SGTC_466 geldanamycin 89.2 µM 1.51374400350895 0.104702163018693 no 432 0.0650453898880917 289 5288382 HSP90 inhibitor. SGTC_2977 9011197 71.43 µM 1.51346026319739 0.104744925598342 no 433 0.0650813937132069 332 2704722 SGTC_2357 9067248 200 µM 1.51258848673125 0.104876390392575 no 434 0.0651921102456231 387 9150235 SGTC_1721 st082152 9.2685 µM 1.51121428744073 0.105083863578906 no 435 0.0653669316964591 382 5296051 SGTC_2910 7948405 25.97 µM 1.50641008697266 0.105811524101236 no 436 0.0659809664313294 366 2971328 SGTC_957 1187-1561 14.1 µM 1.50438749755725 0.106118959363798 no 437 0.0662408107764279 448 1538454 SGTC_1173 0443-0020 122 µM 1.49863953019666 0.106996176808094 no 438 0.0669835859056458 438 5331295 SGTC_2070 5230947 200 µM 1.4972953846163 0.107202064041903 no 439 0.0671582076445678 417 2835538 SGTC_104 0074-0074 590.992 µM 1.49606943291339 0.107390096085831 no 440 0.0673177812273305 275 3943124 SGTC_1686 st019653 115.5 µM 1.49161033847068 0.108076020591797 no 441 0.0679006631720899 390 97252 SGTC_2014 4013930 200 µM 1.49139167446525 0.108109737738773 no 442 0.0679293463315743 480 64556 SGTC_1642 st009582 77.7 µM 1.48465586843249 0.109152085145707 no 443 0.0688175038828922 387 6739311 SGTC_331 k048-0133 24.5 µM 1.4833445663544 0.109355842526838 no 444 0.068991443655632 374 6813582 SGTC_2043 5101342 149 µM 1.48235736639079 0.109509419298803 no 445 0.0691226158128326 439 678451 SGTC_2516 gossypol 71.55 µM 1.48123174520304 0.109684718905132 no 446 0.0692724147994657 446 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1870 st057514 26.5 µM 1.47303570537805 0.110967212398163 no 447 0.0703707041606924 426 5393161 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.46851334990711 0.111679439371945 no 448 0.0709824163306769 446 94937 An inhibitor of serotonin biosynthesis. SGTC_212 3807-4682 38.772 µM 1.46777737941414 0.111795656276741 no 449 0.0710823519441977 579 3125501 YBL034C STU1 SGTC_847 0342-0274 5.54 µM 1.46250100721101 0.112631380359643 no 450 0.0718019842727637 444 18097 SGTC_1877 wortmannin 25 µM 1.46208576092752 0.112697340062198 no 451 0.0718588550883715 509 312145 A covalent inhibitor of PI 3-kinase. SGTC_766 1391-0721 126 µM 1.46129467826353 0.11282307573117 no 452 0.0719672948488005 433 1020919 YIL115C NUP159 SGTC_3240 9133527 49.47 µM 1.4571392797098 0.113485184783978 no 453 0.0725389687966352 429 17617455 SGTC_971 1315-0384 26.7 µM 1.45707438353169 0.113495547079167 no 454 0.0725479243160861 452 6769120 SGTC_2680 butyl paraben 22.24 µM 1.45687032825876 0.113528133994461 no 455 0.0725760889802586 384 7184 An antifungal and steroid mimetic. SGTC_2915 7971052 15.16 µM 1.45155336640091 0.114379587008969 no 456 0.0733129166743767 306 5741558 SGTC_1847 st056231 15 µM 1.44849913077851 0.114870740305743 no 457 0.0737387544517311 527 5393180 SGTC_2753 fluvastatin 17.09 µM 1.44768048283789 0.115002642107161 no 458 0.0738532153860328 480 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_101 0490-5701 117.494 µM 1.44681795462302 0.115141730454959 no 459 0.0739739583729438 387 4661669 SGTC_591 4299-0174 154 µM 1.44420921219682 0.115563135126329 no 460 0.0743400671780687 417 5509088 SGTC_3065 9113888 49.47 µM 1.44401133446559 0.115595144067701 no 461 0.0743678935318314 413 16648368 SGTC_1274 0865-0114 173 µM 1.44253946325099 0.115833433415441 no 462 0.0745751235616553 452 870624 SGTC_884 0851-0618 334 µM 1.43857677429667 0.116476708130494 no 463 0.0751352353725927 482 9642473 SGTC_2167 5876490 200 µM 1.43776369055429 0.116609011057474 no 464 0.075250557439507 469 686534 SGTC_2987 9018338 71.43 µM 1.4371914680247 0.116702185526798 no 465 0.0753317983171169 465 5055682 SGTC_1449 4112-4002 201 µM 1.43649783025835 0.116815200687157 no 466 0.0754303666545822 441 2059539 SGTC_1811 st050069 61.5 µM 1.43576024321226 0.116935461640466 no 467 0.0755352881382294 384 3877702 SGTC_129 0088-0017 176.636 µM 1.43505159297224 0.117051087175325 no 468 0.0756361980851478 453 182446 SGTC_1730 st033808 45.1 µM 1.43440860780799 0.117156068675368 no 469 0.0757278463375391 528 1045166 SGTC_598 3937-0236 20.2 µM 1.43393018752697 0.117234224600176 no 470 0.0757960931098944 523 1379313 SGTC_3006 9075424 71.4286 µM 1.43356610343869 0.117293727023091 no 471 0.0758480611778925 440 7465181 SGTC_3310 9130229 44.1445 µM 1.43090501183041 0.117729279964486 no 472 0.0762287202411275 434 7761258 SGTC_1406 3909-7906 11.9 µM 1.42936680048798 0.117981567426948 no 473 0.0764494176933746 454 X1406 SGTC_791 1348-1292 225 µM 1.4266547092185 0.118427318206121 no 474 0.0768397231792929 552 5437054 SGTC_574 1315-0397 40 µM 1.42315058864119 0.119005005221216 no 475 0.0773462529388583 544 6794277 SGTC_674 0498-0004 451 µM 1.42173931573654 0.119238227896537 no 476 0.0775509710726882 460 4231473 SGTC_938 3126-1755 342 µM 1.4176602033749 0.119914142787613 no 477 0.0781449971101647 486 1777771 SGTC_3282 9108498 15.4605 µM 1.41670852784152 0.120072224652924 no 478 0.0782840813640007 489 16459645 SGTC_3242 9133940 49.47 µM 1.40760999771054 0.121590989139509 no 479 0.0796232926936539 454 17248444 SGTC_3285 9112818 20.8695 µM 1.40692715249756 0.121705514754521 no 480 0.0797244955792603 515 17017947 YPR165W RHO1 SGTC_1706 st031321 9.9705 µM 1.40305065838446 0.122357110211858 no 481 0.0803008666132125 466 6103185 SGTC_910 3454-3003 490 µM 1.40244461582757 0.122459200117708 no 482 0.0803912591064381 507 820824 SGTC_1596 piperlongumine 63 µM 1.40241397664415 0.122464362978031 no 483 0.0803958310444836 515 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.39854596996785 0.12311736922602 no 484 0.0809745891270615 465 521171 SGTC_681 1642-0006 26.6 µM 1.39449994024566 0.123803037241023 no 485 0.0815833437671409 419 4446530 SGTC_2999 9069765 71.4286 µM 1.39323407111868 0.124018108099625 no 486 0.0817745099538326 506 2097066 SGTC_41 0478-0632 82.643 µM 1.39077341230824 0.124436921172229 no 487 0.0821470739769079 569 3750424 SGTC_891 0929-0073 133 µM 1.38774639102377 0.124953486478076 no 488 0.0826071421243953 470 5603632 SGTC_2803 7707263 71.43 µM 1.38013033795324 0.126259796436355 no 489 0.0837732589148988 457 2199229 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.37630828848582 0.126918931001062 no 490 0.0843631039465296 484 97141 SGTC_3232 9132874 49.47 µM 1.37573719353344 0.127017624948591 no 491 0.0844515062188465 466 3784940 SGTC_1866 st057638 64 µM 1.37452600298401 0.127227113939586 no 492 0.0846392216486838 476 688802 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.37371776894097 0.12736704073137 no 493 0.0847646591561457 569 688788 SGTC_566 0958-0068 16.5 µM 1.371227392604 0.127798863935568 no 494 0.0851520407818408 436 6815365 SGTC_2576 guaiol 23.12 µM 1.36980912519943 0.128045241142962 no 495 0.0853732463981277 537 227829 SGTC_95 0471-0001 561.058 µM 1.36715270514221 0.128507593877505 no 496 0.0857887230284389 514 4015405 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.36122049281494 0.129544281318762 no 497 0.0867220099571495 484 5355888 SGTC_143 4032-1194 15.74 µM 1.36004638894925 0.129750147477105 no 498 0.0869076222968443 604 1806963 SGTC_245 methotrexate 289.6 µM 1.35950407704137 0.12984531233661 no 499 0.0869934557173287 543 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1617 st002906 78 µM 1.35386313946792 0.130838049768182 no 500 0.0878900226425527 540 5150859 SGTC_202 3594-0513 34.79 µM 1.35380092467046 0.130849027994931 no 501 0.0878999492994472 470 708429 SGTC_366 0181-0206 4.31 µM 1.35095868412988 0.131351239770728 no 502 0.0883543339653362 542 274874 SGTC_2784 7567673 72.73 µM 1.34891818958255 0.131712606174758 no 503 0.0886816225162283 550 3471247 SGTC_1375 2910-0797 186 µM 1.3486635831541 0.13175774441968 no 504 0.0887225238215071 505 742508 SGTC_1325 1431-0015 227 µM 1.34618206304901 0.132198243040782 no 505 0.0891219041395388 494 1103340 SGTC_1032 k061-1018 98.7 µM 1.34069419524131 0.133176005604852 no 506 0.0900098799968554 603 4005393 SGTC_1309 pyrazolanthrone 13.4 µM 1.33956090163086 0.133378540686884 no 507 0.0901940711249372 550 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1264 0783-0040 158 µM 1.33773103689353 0.133706009640918 no 508 0.0904920648384995 483 2855798 SGTC_797 k781-0471 270 µM 1.33099783650741 0.13491572641997 no 509 0.0915948614054695 526 23738129 SGTC_1466 k213-0079 57.5 µM 1.32613169095633 0.135794659872983 no 510 0.0923980403151228 542 3657981 SGTC_3119 9125183 49.47 µM 1.3248185620586 0.136032510359651 no 511 0.0926156683635208 389 22695334 SGTC_1964 st076914 61 µM 1.32405540050163 0.136170874777682 no 512 0.0927423230747323 492 24208661 SGTC_3083 9117465 49.47 µM 1.32255987356531 0.136442299369433 no 513 0.0929908929204103 530 16420915 SGTC_2992 9074591 71.4286 µM 1.32219142836823 0.136509225614058 no 514 0.0930522073232247 514 17741321 SGTC_1986 st071812 45 µM 1.32215628393181 0.136515610599586 no 515 0.093058057406748 481 11838594 SGTC_1474 0330-0125 5.35 µM 1.3212196842771 0.136685845798904 no 516 0.0932140623756247 518 X1474 SGTC_51 1013-0126 23.419 µM 1.32026439525981 0.136859627411733 no 517 0.0933733793325752 505 1627850 SGTC_2420 aureobasidin a 50 nM 1.3147440932609 0.137866811643056 no 518 0.0942979611370276 579 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2552 juarezic acid 87.02 µM 1.3144609654255 0.137918604555162 no 519 0.0943455629131953 623 1549512 SGTC_1518 st038567 90.8 µM 1.31333946584783 0.138123892214605 no 520 0.0945342927568659 486 77966 SGTC_2304 7443016 91.4 µM 1.31232592242479 0.138309597931205 no 521 0.0947050946672097 472 939854 SGTC_1453 4237-0541 195 µM 1.31105070053746 0.138543491165545 no 522 0.0949203174894804 538 739892 SGTC_1616 st002734 56.1 µM 1.3107259578058 0.138603096478069 no 523 0.0949751827646668 555 4026101 SGTC_1147 3809-1045 12.3 µM 1.3106256547414 0.138621510260963 no 524 0.0949921336858498 531 325925 SGTC_1135 dihydrocapsaicin 536.708 nM 1.3098760820654 0.138759170670198 no 525 0.0951188798138022 550 107982 A Capsaicinoid. SGTC_2952 9073731 13.78 µM 1.30634006207032 0.139409822678951 no 526 0.0957184694920246 573 16457353 SGTC_3030 9087619 49.47 µM 1.30429750827269 0.139786610852507 no 527 0.0960660822824783 522 25236973 SGTC_558 k064-0027 21.3 µM 1.30291485673834 0.140042059975899 no 528 0.0963019156107281 551 5088526 SGTC_994 3910-0338 138 µM 1.2942013255479 0.141659207652914 no 529 0.0977979445239984 591 3479481 SGTC_720 r052-1644 49.9 µM 1.29208513802104 0.142053853333063 no 530 0.0981638310677528 480 1422863 YOR257W CDC31 SGTC_2142 5622915 118.518 µM 1.28895211558859 0.14263949287994 no 531 0.0987073671140361 509 5322196 SGTC_1491 4138-0063 26.5 µM 1.28720585888359 0.14296661910134 no 532 0.0990112728463016 513 23883227 SGTC_275 trichlorophene 5.69 µM 1.28696365613316 0.143012030937648 no 533 0.0990534780308018 718 62616 SGTC_1112 tnp00069 1.16933 µM 1.28626495189201 0.143143089189498 no 534 0.0991753048878376 619 145826 SGTC_2199 6590217 200 µM 1.28604699441639 0.143183988786574 no 535 0.0992133306108552 466 703109 SGTC_2050 5263056 171 µM 1.28402103091781 0.143564537373507 no 536 0.0995672984430431 643 763468 YGL055W OLE1 SGTC_1088 bifonazole 369 nM 1.28389406832181 0.143588408211904 no 537 0.0995895115050832 540 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_430 0958-0115 16.4 µM 1.28275025900042 0.143803581994021 no 538 0.0997897928484995 543 6833180 SGTC_688 0527-0193 473 µM 1.28135865839942 0.144065663559752 no 539 0.100033859067141 522 4007154 SGTC_625 k213-0058 121 µM 1.27982662631049 0.14435456500502 no 540 0.100303058655168 763 3655420 SGTC_351 caspofungin 25 nM 1.27715838576818 0.144858657495514 no 541 0.10077316769728 704 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1401 3807-4679 7.6 µM 1.27674999156163 0.144935917093316 no 542 0.10084526296244 522 3291456 SGTC_1729 st035615 45.989 µM 1.27653040398798 0.144977469911768 no 543 0.100884043072679 556 17385451 SGTC_1992 st073643 23.3 µM 1.27433487992891 0.145393372483977 no 544 0.101272380037549 541 3161292 SGTC_140 0062-0056 502.533 µM 1.27391384558405 0.14547322149236 no 545 0.101346975481709 590 3758964 SGTC_2866 9034245 58.44 µM 1.27223273252723 0.145792337901655 no 546 0.101645220431216 495 6462273 SGTC_2649 anisomycin 9.56 µM 1.27061488881127 0.146099888213743 no 547 0.101932843772943 514 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3010 9080089 71.4286 µM 1.26817978635819 0.146563619626926 no 548 0.102366876928872 568 17027233 SGTC_1367 1812-0510 76.9 µM 1.26696645791879 0.146795049515471 no 549 0.102583641823764 553 1142582 YDR527W RBA50 SGTC_611 3453-1652 23.7 µM 1.26598837128396 0.146981787831814 no 550 0.102758622792827 601 1560575 SGTC_1188 1403-0014 4.57 µM 1.26584814362196 0.147008573437573 no 551 0.102783727470971 630 9614867 SGTC_235 0330-0087 5 mM 1.26454811720253 0.147257054000392 no 552 0.103016680821309 590 46494818 YHR062C RPP1 SGTC_1498 4478-3555 97.6 µM 1.26167610343076 0.147806993793547 no 553 0.103532679546631 510 3437919 SGTC_2534 helenine 20.12 µM 1.25556316145204 0.148982087131372 no 554 0.104637197331826 520 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_427 1354-0053 47.3 µM 1.25373271628697 0.149335165299152 no 555 0.104969586108385 574 6813657 SGTC_2272 7805186 180 µM 1.25219217794846 0.149632755365152 no 556 0.105249922780421 565 2956062 YPR165W RHO1 SGTC_1554 st069299 38.7 µM 1.25045109645077 0.149969560910356 no 557 0.105567404540439 583 24207999 SGTC_1743 st037606 46.3785 µM 1.25018783950806 0.150020530919828 no 558 0.105615468980228 559 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1138 3761-0006 1.03 µM 1.24807615831981 0.150429798070987 no 559 0.106001584221122 552 12061087 SGTC_306 1672-3436 11.6 µM 1.24548001429158 0.150933977965412 no 560 0.106477678729422 606 6797378 SGTC_1755 st041960 45.185 µM 1.24499598234488 0.151028102846806 no 561 0.106566613532006 571 2257073 SGTC_1353 1498-1206 8.11 µM 1.24265516088777 0.151483850259298 no 562 0.106997466875635 668 6756808 SGTC_3209 9113616 49.47 µM 1.24246999101638 0.151519940987268 no 563 0.107031602932696 630 16649353 SGTC_3233 9132340 49.47 µM 1.24040947666745 0.151921933415587 no 564 0.107411988797313 567 17682950 SGTC_3007 9078383 71.4286 µM 1.23995444736842 0.152010801976761 no 565 0.10749612169234 593 6496995 SGTC_1573 oleylamine 1.06 µM 1.23818158209651 0.152357377060142 no 566 0.107824369580244 587 5356789 An amine of the fatty acid oleic acid. SGTC_2556 citropten 84.59 µM 1.23381191938737 0.153213834475718 no 567 0.108636498425939 639 2775 A potential DNA crosslinker. SGTC_1834 st055981 52.8 µM 1.23297178526407 0.153378866401061 no 568 0.10879314549406 608 471719 YDL150W RPC53 SGTC_2555 cholic acid 100 µM 1.23151700824728 0.153664914237103 no 569 0.109064779692 591 6708657 Influences liver metabolism. SGTC_3281 9140613 49.47 µM 1.22494014015724 0.154962506673386 no 570 0.110298887548909 544 16013766 SGTC_2195 6536160 144.242 µM 1.21802508716389 0.156334603651477 no 571 0.111607219737997 537 3834386 SGTC_3132 9126706 49.47 µM 1.21784226696196 0.156370987403696 no 572 0.111641959448009 574 850858 SGTC_1084 voriconazole 435 nM 1.2175908980678 0.156421022399844 no 573 0.111689737491291 603 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1660 st012960 28.1 µM 1.21702910789752 0.156532884882272 no 574 0.11179657061966 606 24207266 SGTC_1361 1608-0041 5.61 µM 1.2162526812976 0.15668757199976 no 575 0.111944340478692 618 X1361 SGTC_1246 0422-0085 105 µM 1.21201443450965 0.157533729038114 no 576 0.112753427633464 658 264295 SGTC_339 3091-4833 71.4 µM 1.21076069726736 0.15778460947067 no 577 0.112993566110261 613 3240077 SGTC_675 1309-0189 238 µM 1.21009033456182 0.157918860726466 no 578 0.113122115788174 614 4246530 SGTC_1373 2887-0003 58.5 µM 1.207212684547 0.15849600969557 no 579 0.113675123343021 587 776948 SGTC_190 3970-0790 3.722 µM 1.20709305706898 0.158520032407643 no 580 0.113698154201847 577 2832352 SGTC_2620 irigenin 100 µM 1.20554047559019 0.158832027026616 no 581 0.113997361230375 627 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2299 7976368 114.88 µM 1.20281066923143 0.159381562834555 no 582 0.114524797560427 595 2979718 SGTC_2054 5233173 129 µM 1.20113404229125 0.159719700041981 no 583 0.114849604842202 667 6889 SGTC_760 0568-0725 82.9 µM 1.19903562897288 0.160143562768762 no 584 0.11525704599692 659 3916171 SGTC_2463 5473429 200 µM 1.19875807914645 0.160199680631937 no 585 0.115311013663848 602 5399405 SGTC_1376 2910-0861 41.3 µM 1.19830810435322 0.160290688449675 no 586 0.115398546347459 649 1112859 SGTC_2504 purpurogallin 52.29 µM 1.19400983260702 0.161161720505181 no 587 0.116237060920399 582 5281571 An antioxidant. SGTC_1402 3909-7673 35.9 µM 1.1936182115441 0.161241234573191 no 588 0.116313673417111 611 5328014 SGTC_1438 4092-1045 4 µM 1.19158841222742 0.161653771544053 no 589 0.116711335424929 637 1351342 SGTC_512 prima-1 270 µM 1.18979099284392 0.162019653386086 no 590 0.117064275321767 661 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2809 7964133 12.99 µM 1.18965133779293 0.16204810406782 no 591 0.117091729509152 647 1253665 SGTC_2829 7992743 58.44 µM 1.18595610735188 0.162802082500684 no 592 0.117819816880049 645 16462845 SGTC_196 k015-0023 18.111 µM 1.18593474993679 0.162806446909179 no 593 0.117824034315277 664 5211998 SGTC_2981 9013952 38.96 µM 1.18555732730147 0.162883586144017 no 594 0.117898581348402 591 2996344 SGTC_2210 7115885 190.385 µM 1.18284549009106 0.16343854161195 no 595 0.118435194111855 657 2927039 SGTC_3154 9100113 49.47 µM 1.18045884510585 0.163927963931524 no 596 0.118908884787241 633 25237525 SGTC_3118 9124250 49.47 µM 1.18030269171433 0.163960018963972 no 597 0.118939923986287 563 1504786 SGTC_2561 acetosyringone 100 µM 1.17646928237807 0.164748213171615 no 598 0.119703700167587 715 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_623 k072-0108 16.9 µM 1.1759915988931 0.164846602244102 no 599 0.11979911659832 643 5382803 SGTC_2646 retinol 96.75 µM 1.17342958170157 0.165374953459721 no 600 0.120311790143207 631 445354 A vitamin A analog and teratogen. SGTC_2529 gangaleoidin 93.61 µM 1.17177736998995 0.165716260785884 no 601 0.120643225289802 635 4565183 SGTC_88 0180-0332 8.668 µM 1.17133235178071 0.165808268679555 no 602 0.120732606123838 643 3101745 SGTC_3033 9090887 49.47 µM 1.16554304428115 0.167008221242635 no 603 0.121899623603363 668 19325384 SGTC_1414 3917-0015 5.4 µM 1.16518609100216 0.167082389964048 no 604 0.121971837253131 614 6618702 SGTC_2309 7664088 163.95 µM 1.16333928790069 0.16746646286296 no 605 0.122345935734641 714 704922 SGTC_2191 5911152 200 µM 1.16317484853837 0.167500688274359 no 606 0.122379284469886 636 2875902 SGTC_1818 st052136 56.3 µM 1.16214004986145 0.167716168390232 no 607 0.122589290759777 638 674169 SGTC_490 phenamil 164 µM 1.15963838663575 0.168237836432036 no 608 0.123098032625998 539 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_513 4245-1575 41.7 µM 1.15707185134473 0.168774115709762 no 609 0.123621502982077 771 719745 SGTC_79 0052-0007 94.094 µM 1.15702191770347 0.168784560259828 no 610 0.123631702879559 667 2801472 SGTC_1871 st057448 67.3 µM 1.15357587511225 0.169506367481456 no 611 0.124337046887984 689 691747 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.14871917459292 0.170527008260453 no 612 0.125335898324313 747 368090 SGTC_2935 9038016 29.96 µM 1.14801150289479 0.170676054014018 no 613 0.125481907618832 700 6463195 SGTC_662 k832-1615 104 µM 1.14790021797974 0.170699499789941 no 614 0.125504879108175 658 5878478 SGTC_486 niguldipine 82 µM 1.14742836106464 0.170798934650777 no 615 0.125602312657735 600 1236 A calcium channel blocker. SGTC_1759 st043059 70 µM 1.14718249084223 0.170850761805621 no 616 0.125653103214299 688 669426 SGTC_1704 st028805 70.8 µM 1.14696498952031 0.170896617447906 no 617 0.125698045418493 645 2876101 SGTC_146 3448-8650 53.125 µM 1.14454257756488 0.171407864934661 no 618 0.126199345394099 806 2891488 YIL048W NEO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.14131066480336 0.172091477192453 no 619 0.126870332819403 654 616764 SGTC_1100 amiodarone 5.07 µM 1.13897248166006 0.172587131666676 no 620 0.127357316008847 706 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3072 9116419 49.47 µM 1.13546771089313 0.173331785545052 no 621 0.128089701672993 586 17170162 SGTC_914 3820-6779 408 µM 1.13416931713025 0.173608171997762 no 622 0.128361765900682 637 2893481 SGTC_2869 9037858 32.47 µM 1.13322084563682 0.173810248349984 no 623 0.128560761148329 624 27187042 SGTC_132 0417-1715 25.805 µM 1.13094892073568 0.174294900813208 no 624 0.129038295530182 711 6769098 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.13074633108557 0.174338159382273 no 625 0.129080937364428 639 6708760 SGTC_1567 st069303 68.4 µM 1.12940093285075 0.174625612665859 no 626 0.129364369755265 694 5581319 SGTC_1683 st010134 710 nM 1.12780244796968 0.17496753055024 no 627 0.129701679664046 674 3818134 SGTC_2820 7989630 71.43 µM 1.12666986462884 0.175210048463414 no 628 0.129941044105468 564 2984098 SGTC_1676 st018489 23.4 µM 1.1227520505754 0.17605060572918 no 629 0.130771407479484 685 3696235 SGTC_2289 7946404 165.07 µM 1.1224658339245 0.176112112706545 no 630 0.13083221327429 740 1246120 YPR165W RHO1 SGTC_1463 k081-0032 34.1 µM 1.12242074079933 0.176121804304839 no 631 0.130841794943346 562 977755 SGTC_1499 4480-0877 67.3 µM 1.12219793539744 0.176169695505157 no 632 0.130889145145803 639 2861909 SGTC_2037 5169046 200 µM 1.12015200943866 0.176609845038191 no 633 0.131324495278384 664 5718022 SGTC_2217 6934799 96.0675 µM 1.12010620628843 0.176619706834041 no 634 0.13133425310535 674 675606 SGTC_1654 st012436 41.8 µM 1.1178700873747 0.177101585106149 no 635 0.131811241088143 636 4323132 SGTC_1242 0402-0103 60.1 µM 1.11580787813454 0.177546721694918 no 636 0.132252190425568 640 432868 SGTC_1031 k035-0009 16 µM 1.11578583133591 0.17755148440146 no 637 0.132256910042136 753 5180959 SGTC_189 3970-0742 2.116 µM 1.11545674804079 0.177622584904176 no 638 0.132327371575318 676 2891807 SGTC_457 grayanotoxin iii 135 µM 1.11469361286902 0.17778753415934 no 639 0.13249086950333 739 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2361 9034121 116 µM 1.11446798142767 0.177836322184845 no 640 0.132539236571295 666 6496917 SGTC_370 0180-0345 38.7 µM 1.11438376006114 0.177854535437688 no 641 0.132557293646832 620 3989527 SGTC_211 3455-0679 143.504 µM 1.11390997322144 0.177957015917038 no 642 0.132658905212515 723 748649 SGTC_931 2812-0076 566 µM 1.11323317311907 0.178103472905029 no 643 0.132804149433263 725 3450959 SGTC_2962 9082311 13.18 µM 1.1131791462261 0.178115167394808 no 644 0.132815748555551 646 16459453 SGTC_3052 9092717 49.47 µM 1.11262471317948 0.178235206183827 no 645 0.132934821010302 666 25237534 SGTC_783 0848-0141 92.7 µM 1.11165053802502 0.178446245656233 no 646 0.133144217083272 656 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3115 9123671 49.47 µM 1.11070766865992 0.178650653073335 no 647 0.133347100135878 726 3286988 SGTC_170 4197-0004 226 µM 1.11001076843934 0.178801830840695 no 648 0.133497193108467 632 218692 SGTC_1344 1488-0097 29.1 µM 1.1043756315209 0.180027211313201 no 649 0.134715113515234 679 747966 SGTC_2030 5175110 200 µM 1.09986752024083 0.181011303110431 no 650 0.135694924053273 705 2831986 SGTC_2805 7950783 58.44 µM 1.09942786535681 0.181107457015328 no 651 0.135790740946602 759 1178958 YDL195W SEC31 SGTC_1269 0831-0796 3.05 µM 1.09618275607417 0.18181816197986 no 652 0.13649940218652 711 927758 SGTC_2459 5811157 9.22 µM 1.09614930417226 0.181825497287437 no 653 0.136506720501643 687 2870684 YBR192W RIM2 SGTC_1236 0330-0013 258 µM 1.09569827748202 0.181924416149401 no 654 0.136605418385766 682 4617066 SGTC_1836 st055642 81 µM 1.09477584904942 0.182126827291728 no 655 0.136807424740211 699 8571 SGTC_1920 st075728 45.7 µM 1.09463470187035 0.182157812040238 no 656 0.136838353138989 705 3400306 SGTC_1681 tripelennamine 100 µM 1.09452364926035 0.182182192719338 no 657 0.136862690526144 628 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2216 7189485 200 µM 1.09451727890936 0.182183591338897 no 658 0.136864086690196 731 731273 SGTC_1058 3448-5425 97.3 µM 1.09072532598418 0.183017310675514 no 659 0.137696881576309 683 7279705 SGTC_3069 9117009 49.47 µM 1.0906856138929 0.183026054568143 no 660 0.137705621469452 571 41904981 SGTC_1249 0481-0015 10.2 µM 1.09039800670667 0.183089388308617 no 661 0.137768929764239 651 4227577 SGTC_2433 5607874 27.82 µM 1.09032481721053 0.183105507489041 no 662 0.137785043456763 695 2252428 SGTC_879 0831-1030 162 µM 1.08837936700548 0.183534295939978 no 663 0.138213832991318 752 1549252 SGTC_819 1013-0258 27.7 µM 1.08718685980847 0.183797440525582 no 664 0.1384771184097 715 5753198 SGTC_2903 5923464 63.88 µM 1.08513482826956 0.184250801863642 no 665 0.138930971876132 696 2876576 SGTC_2890 9046729 58.44 µM 1.08332219689077 0.184651850158554 no 666 0.139332718108304 650 903329 SGTC_1856 st057054 55.7 µM 1.0830633616765 0.18470916221827 no 667 0.139390150002074 756 1266018 SGTC_2239 6685329 187.64 µM 1.08174061271491 0.18500222184802 no 668 0.139683900818598 716 805680 SGTC_1206 3978-0017 132 µM 1.08055997596795 0.185264039880259 no 669 0.139946447181001 676 3873677 SGTC_2608 thymoquinone 42.66 µM 1.07966523163276 0.185462611583635 no 670 0.140145640911722 675 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1692 fluoroquinolonic acid 71 µM 1.0778739869115 0.185860541500537 no 671 0.140544997844721 710 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2 0422-0095 29 µM 1.07706169241283 0.186041169320589 no 672 0.1407263527576 604 6790840 SGTC_521 r062-0005 13.8 µM 1.07691041140151 0.18607482130366 no 673 0.140760145670345 700 2832033 SGTC_1960 st011366 51.8 µM 1.07546915014015 0.186395614507918 no 674 0.14108236844192 718 3972846 SGTC_1738 st035555 74 µM 1.07351757175596 0.186830538782612 no 675 0.141519479478846 730 5331140 SGTC_273 hydroxyurea 18.1 mM 1.07043944123622 0.187517799182381 no 676 0.142210776990932 811 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1737 st035557 69.7 µM 1.06744945151601 0.188186873960827 no 677 0.142884464005871 610 5716916 SGTC_2986 9022445 71.43 µM 1.0662640414462 0.188452542362872 no 678 0.143152149793996 732 6459286 SGTC_1362 1611-0397 101 µM 1.06578003345406 0.188561082375272 no 679 0.143261544379404 733 27816 SGTC_432 NS 1619 61.3 µM 1.06478147505895 0.188785133375279 no 680 0.143487415045981 672 4552 A K+/calcium channel activator. SGTC_2013 4024628 200 µM 1.06438793207045 0.188873479424502 no 681 0.143576499200605 665 5230760 SGTC_1296 1068-0102 11.9 µM 1.05967671588738 0.18993307229775 no 682 0.144645849582271 748 767053 SGTC_3170 9103054 49.47 µM 1.05798901532019 0.190313537923382 no 683 0.145030225195076 687 16432970 SGTC_641 4092-0595 30 µM 1.04611553909979 0.193003438865376 no 684 0.147753845856378 777 786260 SGTC_1091 telmisartan 47.6 µM 1.04530630410046 0.193187609869982 no 685 0.14794071248747 773 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2975 9084847 53.72 µM 1.04438195469038 0.193398110567214 no 686 0.14815435454629 773 27211724 SGTC_1416 3966-0321 25.3 µM 1.04377187866011 0.193537118892327 no 687 0.148295472593366 774 582530 YLR208W SEC13 SGTC_1178 0988-0033 191 µM 1.0433148145853 0.19364130273704 no 688 0.148401256002956 769 5392207 SGTC_233 rapamycin 362 pM 1.04245180352819 0.193838111951642 no 689 0.148601129804433 793 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1765 st044815 90.4 µM 1.03479236349077 0.195590181184492 no 690 0.150382945008048 740 645695 SGTC_2241 6772625 37.8075 µM 1.03444289612942 0.195670349285293 no 691 0.150464579740794 721 2285411 SGTC_2018 5133068 143 µM 1.0341987879999 0.195726359723236 no 692 0.150521620320873 731 785362 SGTC_1959 st077091 55.8 µM 1.03348335724369 0.195890570854757 no 693 0.150688877496898 788 821356 YKL052C ASK1 SGTC_3164 9100705 49.47 µM 1.03310613222062 0.195977188072629 no 694 0.150777116964378 721 17174235 SGTC_3040 9091894 49.47 µM 1.03233133137717 0.196155168251869 no 695 0.150958464177657 698 25236966 SGTC_608 k048-0125 159 µM 1.0321556590495 0.196195535723382 no 696 0.15099960161682 791 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2628 lathosterol 100 µM 1.03196738150417 0.196238805320338 no 697 0.151043699119627 774 6710616 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.02913904480609 0.196889504506793 no 698 0.151707170423731 756 7104 SGTC_2928 9011484 9.79 µM 1.02891706468452 0.196940629425145 no 699 0.151759324374354 725 2994751 SGTC_1180 1193-0155 285 µM 1.02774743351404 0.197210143450937 no 700 0.152034324513042 728 2921347 SGTC_2411 st077133 39.94 µM 1.02739124426106 0.197292263200321 no 701 0.152118136353612 828 1403142 YNL221C POP1 SGTC_667 1498-1044 59 µM 1.02484259981814 0.197880458738956 no 702 0.152718731105901 799 6739982 SGTC_2961 9083290 32.55 µM 1.0195160421959 0.199113177912168 no 703 0.153979020557044 741 17741490 SGTC_802 4112-3352 742 µM 1.01932012617215 0.199158606569512 no 704 0.154025506081812 834 704594 SGTC_1086 cerivastatin 2.18 µM 1.01470402531957 0.20023078546016 no 705 0.155123467378559 758 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_315 k915-0449 187 µM 1.01430010161901 0.200324769318974 no 706 0.155219787789571 874 20970215 YNL149C PGA2 SGTC_1641 st009299 47.1 µM 1.01183498109477 0.200898921029476 no 707 0.155808480616449 738 4046054 SGTC_1942 st076330 65.2 µM 1.00931357252159 0.201487203086414 no 708 0.156412136478 764 24208414 SGTC_2135 5326629 150.42 µM 1.00484780573612 0.202531662496679 no 709 0.157485070157704 727 5020077 SGTC_818 4072-2707 53.5 µM 1.00433733168985 0.202651258626856 no 710 0.15760802266347 771 882871 SGTC_841 0251-0215 91.2 µM 1.0039533795275 0.20274124045286 no 711 0.157700542723563 842 3888614 SGTC_3151 9099821 49.47 µM 1.00069989602204 0.203504674442368 no 712 0.158485958849128 768 17174189 SGTC_3200 9114385 49.47 µM 1.00047231271602 0.203558141242933 no 713 0.158540995070692 731 17018030 YLR208W SEC13 SGTC_1174 0739-0097 51.1 µM 0.999141864605109 0.20387087485686 no 714 0.158862986667863 795 728447 SGTC_433 pimozide 108 µM 0.995168419623515 0.204806571408129 no 715 0.159827179227464 670 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2212 7123476 200 µM 0.991473427616193 0.205678983392624 no 716 0.160727230652701 726 1085715 SGTC_2931 9014674 55.67 µM 0.989137729791629 0.206231593052212 no 717 0.161297879973891 779 2996810 SGTC_2965 9082772 38.63 µM 0.98772392616535 0.206566516205779 no 718 0.161643936687116 843 16459634 SGTC_519 k048-0011 62.8 µM 0.986975504012182 0.20674394408513 no 719 0.161827323734235 801 6836379 SGTC_78 0336-0123 156.75 µM 0.986322547715408 0.206898813621097 no 720 0.161987429321247 748 6765896 SGTC_1852 st056254 31.4 µM 0.98592923240297 0.206992134094043 no 721 0.16208392043735 791 442583 SGTC_1070 indatraline 8.81 µM 0.98459070428554 0.207309908280792 no 722 0.162412578777509 811 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_496 calpeptin 138 µM 0.983602896048828 0.207544604454302 no 723 0.162655400323757 724 73364 A calpain inhibitor. SGTC_2891 9063876 19.48 µM 0.97511145750571 0.209568577421895 no 724 0.164752487933926 771 6472478 SGTC_1903 st060211 78.3 µM 0.974599237306058 0.209691037584509 no 725 0.164879546051706 883 688960 SGTC_2755 lomerizine 42.69 µM 0.967918404306372 0.211292122104975 no 726 0.166542561007209 840 3949 A calcium channel blocker. SGTC_2927 9011802 47.9 µM 0.966548867155478 0.211621218705654 no 727 0.166884803361505 787 43912568 SGTC_3301 9125354 19.7965 µM 0.963729205824707 0.212299720818595 no 728 0.167590853904427 757 41905162 SGTC_1643 st009866 20.2 µM 0.96344329055175 0.212368592245968 no 729 0.167662555123955 844 3156273 YOR207C RET1 SGTC_653 0203-0016 55.2 µM 0.963335802989723 0.212394487284999 no 730 0.167689515733531 860 295302 SGTC_2311 7694451 200 µM 0.96290951909873 0.212497202337574 no 731 0.167796466047505 831 2163142 SGTC_2499 avocadenofuran 51.48 µM 0.962576072738552 0.2125775679852 no 732 0.167880154971111 789 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_858 0438-0351 2.77 µM 0.962483830286378 0.212599802954245 no 733 0.167903310879578 885 2799119 SGTC_3131 9127911 49.47 µM 0.961526822490662 0.21283056905024 no 734 0.168143672821189 798 45595681 SGTC_2102 5377816 72.7585 µM 0.960775497479727 0.213011840660193 no 735 0.168332530558288 874 1379702 SGTC_1273 0849-0096 14.1 µM 0.960552354713896 0.213065695489345 no 736 0.168388647381654 836 5286025 SGTC_2442 5158906 48.48 µM 0.960178470755069 0.213155949050232 no 737 0.168482700158649 851 1893835 SGTC_2988 9073640 71.4286 µM 0.9593110915716 0.213365415533044 no 738 0.168701024699268 797 9102229 SGTC_2936 9038235 15.59 µM 0.959189812073499 0.213394713309497 no 739 0.168731565958637 816 4749415 SGTC_2277 7947813 106.88 µM 0.958758758643276 0.213498862888315 no 740 0.168840144921503 814 1246798 SGTC_1341 1486-1360 280 µM 0.956526136241004 0.214038774942924 no 741 0.169403243135034 840 3976547 SGTC_2255 7941087 197.44 µM 0.954554903616652 0.21451613536588 no 742 0.169901415899674 927 935561 SGTC_2016 5121758 140 µM 0.953494194377494 0.214773256263187 no 743 0.170169868160725 909 2795203 SGTC_489 paxilline 115 µM 0.952465021450498 0.215022903681351 no 744 0.170430598625408 795 105008 A toxic potassium channel blocker. SGTC_2178 5812956 200 µM 0.952341302411523 0.215052925663127 no 745 0.170461958799766 848 5403383 SGTC_2423 st077119 87.2 µM 0.952101268088187 0.215111179953727 no 746 0.17052281299163 818 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2012 4023501 200 µM 0.949885281527291 0.215649413585284 no 747 0.171085273163574 776 3477460 SGTC_90 0870-0863 4.608 µM 0.948772005998673 0.215920107800035 no 748 0.171368291276909 880 1738164 SGTC_1390 3413-2614 145 µM 0.948102327087264 0.216083035784625 no 749 0.171538681850965 876 3421432 SGTC_2105 5350118 200 µM 0.947003403434188 0.216350550118684 no 750 0.171818522331365 867 2133313 SGTC_3225 9130819 49.47 µM 0.946772387095257 0.216406811505979 no 751 0.171877387618407 867 4547121 SGTC_3356 9151811 4.48 µM 0.945084380026098 0.216818163220959 no 752 0.172307899560668 843 1859254 YPR165W RHO1 SGTC_1232 0279-0259 161 µM 0.943985785961073 0.21708612312017 no 753 0.172588455945009 854 1560000 SGTC_285 1486-1325 46 µM 0.943376020563381 0.217234934549643 no 754 0.172744302037048 889 22310230 SGTC_1618 st003135 44.5 µM 0.943317149198628 0.217249305049176 no 755 0.172759353344818 844 1270615 SGTC_171 k064-0041 9.68 µM 0.943158343409593 0.217288072278757 no 756 0.172799958488354 778 53325 SGTC_3169 9102970 49.47 µM 0.941685223727297 0.217647876551571 no 757 0.173176911186883 888 17027839 SGTC_2956 9076196 2.52 µM 0.941335659520352 0.217733306814505 no 758 0.173266437068722 875 16423868 SGTC_2741 miltefosine 3.04 µM 0.940521461805417 0.217932364201469 no 759 0.173475073133038 764 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2709 st078560 56 µM 0.939080912642436 0.218284810739109 no 760 0.173844601683043 884 17250903 SGTC_2143 5623677 140.463 µM 0.938248306385227 0.218488666877602 no 761 0.174058409313742 849 5375313 SGTC_1673 st016611 27.3 µM 0.938174236674098 0.218506807487634 no 762 0.174077438006093 898 5226799 SGTC_2226 7298446 200 µM 0.935852404404138 0.219075893153061 no 763 0.174674592809785 837 3283010 SGTC_318 1488-0629 67.2 µM 0.935008686564776 0.219282900994872 no 764 0.174891911400217 829 3662576 SGTC_2830 7992007 71.43 µM 0.93278261112948 0.219829612296328 no 765 0.175466110568075 820 1952075 SGTC_540 1187-0821 17.3 µM 0.932505397691059 0.219897749057524 no 766 0.175537699235997 849 847520 SGTC_922 1866-0035 480 µM 0.93174996745909 0.220083489039506 no 767 0.175732878392093 955 3156169 SGTC_1165 k072-0275 30.3 µM 0.931582517660715 0.220124672624373 no 768 0.175776160704756 861 6153523 YGL055W OLE1 SGTC_18 0111-0177 500 nM 0.931426984867953 0.220162929230313 no 769 0.175816368766289 972 721752 SGTC_1769 st044406 64.4 µM 0.926585911517514 0.221355599465197 no 770 0.177070786246252 881 670903 SGTC_2259 7964009 200 µM 0.925498663234362 0.221623966387483 no 771 0.177353289360151 820 313134 SGTC_2904 7225135 42.03 µM 0.923883495795603 0.222022983360887 no 772 0.177773488424742 941 4446116 SGTC_731 3966-0296 387 µM 0.923552258924497 0.222104864001274 no 773 0.177859739959476 879 660956 SGTC_1289 0976-0073 69.1 µM 0.922709590921587 0.222313246380439 no 774 0.178079283189859 909 3391136 SGTC_2787 5284540 71.43 µM 0.922533400678502 0.222356830352753 no 775 0.178125208233998 876 736958 SGTC_2128 5255449 168.493 µM 0.921467678594083 0.222620560649879 no 776 0.178403154226736 928 736008 SGTC_789 1309-1135 70.6 µM 0.920713272515195 0.222807358471293 no 777 0.178600072427965 876 3092424 SGTC_2855 9016525 58.44 µM 0.92049799335015 0.222860679929798 no 778 0.178656290581915 900 43811474 SGTC_549 1661-1316 519 µM 0.920184347599047 0.222938378344374 no 779 0.178738216196713 929 2857282 SGTC_685 1278-0033 54.9 µM 0.919682283319841 0.223062785165499 no 780 0.178869406762978 910 3590572 SGTC_557 1315-0110 16.2 µM 0.919080742788124 0.223211893314536 no 781 0.179026670491999 911 6833801 SGTC_700 3453-2283 142 µM 0.918765530116402 0.223290049981175 no 782 0.179109112833667 936 565664 SGTC_2387 9077560 195.08 µM 0.917343468202106 0.223642842381093 no 783 0.17948134306771 868 5303272 SGTC_1516 st013856 110 µM 0.917176255909837 0.223684346078395 no 784 0.179525143463588 846 5281404 A mutagen and neurotoxin. SGTC_1346 1488-2224 62.4 µM 0.916955752832079 0.223739083755329 no 785 0.179582913375857 908 3722427 SGTC_311 1315-0136 58 µM 0.916405308374402 0.223875759296008 no 786 0.179727176073092 892 6759207 SGTC_2843 9000894 45.46 µM 0.915970211523569 0.223983827555554 no 787 0.179841259513228 754 2242070 SGTC_1962 st076595 64.5 µM 0.915340306209909 0.224140334352615 no 788 0.180006502774662 894 279619 SGTC_2184 6075246 200 µM 0.915100314222103 0.224199979296508 no 789 0.180069485021908 883 2267320 SGTC_1043 0916-0009 19.3 µM 0.913947885175608 0.22448651673589 no 790 0.180372115192642 1003 3101130 SGTC_2718 lomofungin 53.02 µM 0.913276894152288 0.224653446151147 no 791 0.180548465680525 873 5351222 A RNA synthesis inhibitor. SGTC_2972 9093619 59.92 µM 0.911802324684276 0.225020537403401 no 792 0.180936393202188 859 25236256 SGTC_1293 1000-1278 195 µM 0.911210012179449 0.225168088111302 no 793 0.181092364826015 906 678847 SGTC_1614 st002383 48.6 µM 0.910410874850634 0.225367247690668 no 794 0.181302932361876 891 1947235 SGTC_422 cantharidin 155 µM 0.909048516935957 0.225707001946842 no 795 0.181662258210073 871 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3042 9091578 49.47 µM 0.908803837549968 0.225768052467156 no 796 0.181726840278482 886 25236497 SGTC_617 3770-0098 35 µM 0.902484383352091 0.227348066589926 no 797 0.183399806754455 878 5962639 SGTC_31 0508-1974 57.237 µM 0.90124560753243 0.227658518751612 no 798 0.183728873350083 888 6810525 SGTC_693 4161-2696 114 µM 0.90094566519419 0.2277337237926 no 799 0.183808604874293 874 805759 SGTC_209 4077-0173 175.592 µM 0.900562004485723 0.227829940058992 no 800 0.183910622063472 819 15993494 SGTC_881 0833-0569 170 µM 0.899485143677074 0.228100122534248 no 801 0.184197152758846 862 5418700 SGTC_283 0987-0079 11.7 µM 0.898543800424026 0.228336451414819 no 802 0.184447852455976 951 411556 SGTC_2544 sphondin 68.51 µM 0.898271646477302 0.22840480264424 no 803 0.184520372365204 882 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_380 3970-0968 6 µM 0.897022038799871 0.228718788079462 no 804 0.184853578542721 875 2891601 SGTC_816 0325-0417 81.3 µM 0.896490137248238 0.228852510995396 no 805 0.184995522759761 906 68101 SGTC_2770 toltrazuril 17.5 µM 0.896141319308822 0.228940229524205 no 806 0.18508864570817 949 68591 Kills coccidiodes. SGTC_991 3996-0057 64.7 µM 0.895853566017872 0.22901260610115 no 807 0.185165488313394 870 715343 SGTC_2264 7948757 110.76 µM 0.895556322962589 0.229087383049713 no 808 0.185244885899361 877 2971411 SGTC_2044 5102272 200 µM 0.895097711753046 0.229202781983191 no 809 0.185367428538515 846 592666 SGTC_3312 9133330 71.43 µM 0.894597290161012 0.229328738718073 no 810 0.185501200472794 970 17617324 SGTC_620 0109-0052 432 µM 0.893291835267983 0.229657505914858 no 811 0.185850454611376 942 493037 SGTC_1812 st052057 4.327 µM 0.890826930432497 0.230278989508228 no 812 0.186511012605362 962 3645418 SGTC_1707 st032323 6.317 µM 0.888744734854718 0.230804711521307 no 813 0.187070141595095 907 3132057 YMR211W DML1 SGTC_2929 9013348 24.6 µM 0.887578842562712 0.231099373698439 no 814 0.187383669310353 882 2995952 SGTC_1379 2144-0755 36.5 µM 0.886878139595357 0.23127656705112 no 815 0.18757225610217 986 5392327 SGTC_288 1315-0019 35.1 µM 0.884748330768687 0.231815616843116 no 816 0.188146191236892 950 6811474 SGTC_2888 9058547 12.99 µM 0.883109148981847 0.232230966204492 no 817 0.188588650730143 845 16476514 SGTC_1060 3448-7350 82 µM 0.882792144200799 0.232311339243317 no 818 0.188674292865683 910 570178 SGTC_1267 0828-0272 9.49 µM 0.879168268474517 0.233231231487833 no 819 0.189655023321428 957 745334 SGTC_2473 5854593 8.94 µM 0.876004455940967 0.234035990570081 no 820 0.19051380569102 898 2872951 SGTC_2162 5663267 200 µM 0.874892993120755 0.234319071009537 no 821 0.190816065971739 976 6456493 SGTC_2728 chlorpromazine 9.18 µM 0.872233475537529 0.234997196889839 no 822 0.191540510403759 870 2726 A thorazine and dopamine antagonist. SGTC_2020 4017018 200 µM 0.872214231489075 0.235002107700511 no 823 0.191545758556119 935 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1381 2324-0066 62.1 µM 0.870986307075585 0.235315573955469 no 824 0.191880814827259 882 10885928 SGTC_1695 st026914 34.495 µM 0.870149633434218 0.235529293319779 no 825 0.192109318262485 941 3289191 SGTC_2294 7971431 200 µM 0.869157130224951 0.235782956497275 no 826 0.192380596011627 855 5741572 SGTC_1557 sumaresinolic acid 42.3 µM 0.868545832373332 0.235939266441824 no 827 0.192547796619673 882 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_255 tunicamycin 200.472 nM 0.867906870345845 0.236102711194005 no 828 0.192722658777103 941 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_768 0384-0033 77.3 µM 0.866966079240986 0.236343476496834 no 829 0.192980297823661 937 3965305 YMR134W ERG29 SGTC_251 melphalan 456.522 µM 0.866899360775442 0.236360556079274 no 830 0.192998576900353 1046 460612 A DNA alkylator. SGTC_2147 5545932 89.7195 µM 0.86639538876067 0.236489592260975 no 831 0.193136685919673 933 797404 SGTC_2674 ligustilide 100 µM 0.86456963440524 0.236957379934648 no 832 0.193637522554174 930 5319022 A signalling regulator. SGTC_246 cycloheximide 667 µM 0.863049227341829 0.237347320529022 no 833 0.194055200829022 860 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_73 0327-0325 16.231 µM 0.860164716280976 0.238088081909623 no 834 0.194849125654729 1040 53298 SGTC_390 dec-rvkr-cmk 16.7 µM 0.858565798209563 0.23849923975791 no 835 0.195290057179336 989 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2388 9080168 200 µM 0.857616432611319 0.238743550583361 no 836 0.195552149089899 888 15943073 SGTC_1950 st077106 7.18 µM 0.855191656790676 0.239368166136492 no 837 0.196222527142995 945 13831864 SGTC_1020 4335-0961 93.3 µM 0.853166658891647 0.239890483203884 no 838 0.196783444929002 897 669075 SGTC_1257 0669-0121 16 µM 0.851920053570595 0.240212334758719 no 839 0.197129232888992 1064 4307855 SGTC_771 0250-0039 27.3 µM 0.851519735537651 0.24031573972605 no 840 0.197240352521261 935 3005115 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.849256427898279 0.240900823933032 no 841 0.197869310244948 984 115019 SGTC_1198 1612-1005 86.7 µM 0.847596437464466 0.241330437614706 no 842 0.198331379529944 1005 6998509 SGTC_1921 5740136 50 µM 0.846720296651091 0.241557354894043 no 843 0.198575521434479 1001 1774243 SGTC_3313 9133968 57.047 µM 0.846664680397588 0.24157176321086 no 844 0.19859102535408 1016 1494643 SGTC_3273 9137859 49.47 µM 0.841329798568734 0.242956020158711 no 845 0.200081600709305 1008 2377234 SGTC_2921 7974240 10.71 µM 0.839967209012942 0.243310261858538 no 846 0.200463386137327 963 2979074 YDR527W RBA50 SGTC_1519 esterone 74 µM 0.838248768119591 0.243757414384697 no 847 0.200945501305449 959 698 A steroid. SGTC_3085 9117376 49.47 µM 0.835457938549984 0.24448455551935 no 848 0.201729959882801 987 16480349 SGTC_2329 6138490 200 µM 0.833950773731655 0.244877727592384 no 849 0.202154361967212 855 720019 SGTC_1200 1643-0193 18.4 µM 0.83338981670687 0.245024150548648 no 850 0.202312458004634 1026 5403974 SGTC_2081 5214970 32.255 µM 0.831724094102503 0.245459220702571 no 851 0.202782348742102 999 2063512 SGTC_2325 6158266 200 µM 0.831423397741596 0.245537803802972 no 852 0.202867242876794 964 3623240 SGTC_3268 9137683 49.47 µM 0.830934600957219 0.245665573348914 no 853 0.203005287781475 978 1953228 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.827994704844782 0.246434803169096 no 854 0.203836749345781 1026 688751 SGTC_2687 chenodiol 100 µM 0.822408576942788 0.247899974118366 no 855 0.205422199763306 965 5702181 A cholesterol synthesis inhibitor. SGTC_1766 st045414 44.774 µM 0.820989995879503 0.248272788949986 no 856 0.205825983318821 1077 253960 SGTC_1935 st074532 41.6 µM 0.820563117992449 0.248385034473057 no 857 0.205947581544704 1094 2829742 SGTC_1068 loratadine 26.9 µM 0.820218113003826 0.248475771665261 no 858 0.206045889009272 975 3957 A H1 histamine antagonist. SGTC_930 2810-3379 265 µM 0.819734355011837 0.248603030993196 no 859 0.206183780312434 1067 1015764 SGTC_2706 st078239 82.5 µM 0.819635772279713 0.24862896882214 no 860 0.206211887231625 1051 15434492 SGTC_1396 3511-0007 98.6 µM 0.817696400326761 0.249139524570654 no 861 0.206765283209185 928 X1396 SGTC_2305 7443522 69.23 µM 0.816591078385422 0.249430759030983 no 862 0.207081077627097 1029 5415886 SGTC_1488 4013-0813 75.9 µM 0.81566829292774 0.249674036591583 no 863 0.207344939139245 966 2910057 SGTC_1452 4194-0072 190 µM 0.815632482604283 0.2496834799475 no 864 0.207355182757535 1067 1343545 SGTC_1830 st055982 50.3 µM 0.811440266259439 0.250790297446274 no 865 0.208556441618314 993 455313 An antimicrobial agent. SGTC_278 4092-0821 23.9 µM 0.809205047940505 0.251381493722809 no 866 0.2091986059088 1016 877900 SGTC_353 1988-1175 58.3 µM 0.808639390723395 0.251531221971677 no 867 0.209361300074605 943 2788357 SGTC_2318 6029776 164 µM 0.807696212383134 0.251780983998108 no 868 0.209632742278867 1016 818325 SGTC_1377 2944-0135 198 µM 0.807629950510249 0.251798535653831 no 869 0.209651819906155 1046 1894137 SGTC_1115 galangin 695.678 nM 0.807430185696767 0.25185145390236 no 870 0.209709340889144 1104 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2647 atorvastatin 60.16 µM 0.807257328325721 0.251897249032861 no 871 0.209759121536689 999 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1923 st058458 19.1 µM 0.803708968478518 0.252838286880379 no 872 0.210782536678859 1084 3534982 SGTC_1030 k029-0042 36.7 µM 0.802187211187714 0.25324242869971 no 873 0.211222336500889 1045 6080581 SGTC_1435 4092-0789 56.7 µM 0.801810308750231 0.2533425773006 no 874 0.211331347286362 1047 2248285 SGTC_2731 amoxapine 43.43 µM 0.801662510682862 0.253381855134185 no 875 0.211374103638124 1034 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2640 pentamidine 10.38 µM 0.801482594353219 0.25342967282333 no 876 0.211426158286411 1085 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_158 k038-0087 26.446 µM 0.80125440361741 0.25349032757851 no 877 0.21149219082109 1047 X158 SGTC_408 cantharidin 100 µM 0.79976069124866 0.253887555487468 no 878 0.211924730943024 1022 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1277 0873-0036 22 µM 0.798788342302168 0.254146310933094 no 879 0.212206575672462 1070 5965735 SGTC_786 4544-0069 423 µM 0.798317728528846 0.254271597392412 no 880 0.212343066270268 1047 748821 YLR208W SEC13 SGTC_1037 k284-1091 78.7 µM 0.79711333574882 0.254592377384123 no 881 0.212692605993186 987 3334711 SGTC_1071 trifluoperazine 6.31 µM 0.793489469239162 0.255558841012898 no 882 0.213746351174808 1071 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1403 3909-7815 62.9 µM 0.790374425644245 0.256391133721412 no 883 0.214654566631575 1026 6615483 SGTC_2132 5317594 122.667 µM 0.789419523106265 0.256646551865479 no 884 0.214933424471667 1000 794577 SGTC_686 1319-0111 510 µM 0.788664270700127 0.256848661223241 no 885 0.215154127913107 1081 4562600 SGTC_2725 haloperidol 53.21 µM 0.783724124011077 0.258172709473142 no 886 0.216601002026288 1065 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1473 k844-0725 134 µM 0.783117769543123 0.258335466860375 no 887 0.216778978614837 1165 54682906 SGTC_271 rotenone 740 µM 0.780473935761997 0.259045744335361 no 888 0.217555981690313 1125 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3198 9112019 49.47 µM 0.777060348550529 0.259964310871402 no 889 0.218561583171687 1071 45595555 SGTC_186 3455-3465 67.277 µM 0.776991517970544 0.259982849842499 no 890 0.218581887314384 1010 755278 SGTC_34 0469-0683 81.75 µM 0.774408290318722 0.260679114367529 no 891 0.219344691308073 1076 3690923 SGTC_2824 7998404 51.95 µM 0.773022207366345 0.261053104376102 no 892 0.219754619015039 1019 837851 SGTC_830 4076-0286 57.8 µM 0.770976826695074 0.261605488130215 no 893 0.220360333645117 1152 6866659 SGTC_1119 parthenolide 318.541 nM 0.770888576414726 0.261629334850048 no 894 0.220386489412705 1126 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_45 0kpi-0036 14.9 µM 0.766489474952416 0.26281945876249 no 895 0.221692556025511 1064 2795021 SGTC_3050 9093513 49.47 µM 0.765338763407514 0.26313122611455 no 896 0.222034923617329 1140 25236664 SGTC_225 nsc-122657 1.016 µM 0.765336129188697 0.263131940031788 no 897 0.222035707714313 986 275685 SGTC_1306 1185-0270 9.02 µM 0.765200879848075 0.263168596188828 no 898 0.222075967921521 1102 1548076 SGTC_2810 7959871 45.46 µM 0.763926732063943 0.263514052025556 no 899 0.222455453032008 1110 2974535 SGTC_1777 st045864 34.765 µM 0.761227641316043 0.264246611955071 no 900 0.223260555526913 1089 4691462 SGTC_654 1124-0271 80.9 µM 0.760444806551723 0.264459274900558 no 901 0.223494374505682 1084 5403748 SGTC_536 3852-0578 10.6 µM 0.760120542308335 0.264547389223067 no 902 0.223591267318192 1121 2869208 SGTC_166 k072-0058 166.424 µM 0.755613181793064 0.265773746980388 no 903 0.224940575154032 1147 5846229 SGTC_793 0488-0545 106 µM 0.755103261272886 0.26591266683301 no 904 0.225093513261242 1076 292548 SGTC_885 0865-0106 16.8 µM 0.7548355720358 0.265985609293962 no 905 0.225173823634994 1121 2793380 SGTC_262 fenpropimorph 62.5 µM 0.751814595086141 0.266809495326703 no 906 0.226081281842634 1027 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3079 9117512 49.47 µM 0.75160840915693 0.266865773683208 no 907 0.226143292403403 1159 7185044 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.751272861003712 0.266957374221065 no 908 0.226244229288711 1092 2724278 An inhibitor of dopamine biosynthesis. SGTC_2898 9056270 58.44 µM 0.75082650503118 0.26707924854548 no 909 0.226378537927813 1037 19154699 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.750683557547582 0.267118285277634 no 910 0.226421560384296 1020 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1789 tunicamycin 25 nM 0.747182708164923 0.26807521095434 no 911 0.227476640226238 1136 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2219 9098279 200 µM 0.745566699655359 0.268517513735294 no 912 0.227964602611826 1127 902349 SGTC_1988 st071872 53.4 µM 0.744700836978768 0.268754651867229 no 913 0.228226296540704 1127 16414116 SGTC_2880 9042983 58.44 µM 0.744300896432448 0.268864221087975 no 914 0.228347229531294 1143 6464714 SGTC_1876 myriocin 605 nM 0.743923057834948 0.268967755778125 no 915 0.228461512466409 1134 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1316 1272-0050 65.9 µM 0.743245909724849 0.269153356814927 no 916 0.228666406418646 1122 7340392 SGTC_1521 st012942 49.4 µM 0.73899563468706 0.270319789655647 no 917 0.229954824050735 1162 24207259 SGTC_1652 st011932 78 µM 0.738548295729162 0.270442702852997 no 918 0.230090665182896 1102 1551076 SGTC_647 0140-0236 81 µM 0.73835283663739 0.270496416984039 no 919 0.230150033336917 1164 990837 SGTC_2370 9071495 200 µM 0.73815184274097 0.270551657693709 no 920 0.230211091551654 1076 21791103 SGTC_1364 1653-0028 37.6 µM 0.738084559545404 0.270570150914557 no 921 0.230231532961511 1090 5718652 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.737884169510824 0.270625233150411 no 922 0.230292419776292 1157 16623 A steroid. SGTC_1315 1237-0019 3.69 µM 0.737178117408335 0.270819353929658 no 923 0.230507019468914 1136 825140 SGTC_3239 9133757 49.47 µM 0.736996809767127 0.270869213561132 no 924 0.230562144713204 1130 17036923 SGTC_1609 st001574 46.4 µM 0.736198507517374 0.27108880129066 no 925 0.2308049502066 1147 3960012 SGTC_2197 6588183 93.1375 µM 0.734427635810936 0.271576228848165 no 926 0.231344074391971 1127 884136 SGTC_2386 9075165 157.42 µM 0.731076084597907 0.272499927096753 no 927 0.232366340556742 1129 16452277 SGTC_812 4251-0442 148 µM 0.729374227146013 0.27296956091489 no 928 0.232886389315313 1139 5723007 SGTC_1515 3460-0031 42.1 µM 0.727417165397333 0.273510114909752 no 929 0.23348522112069 1089 2876596 SGTC_499 genistein 192 µM 0.725958615640072 0.273913320735017 no 930 0.233932070546987 1163 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_663 1486-0733 13.9 µM 0.725525528331568 0.274033101229899 no 931 0.234064844758731 1130 722445 YPR165W RHO1 SGTC_1090 efavirenz 20.7 µM 0.724676898669587 0.274267884774214 no 932 0.234325135294872 1152 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2338 7999974 200 µM 0.724569005665094 0.274297741779665 no 933 0.234358239565368 1207 315925 SGTC_1143 3454-2408 5.08 µM 0.722107489384533 0.274979347658569 no 934 0.235114196983612 1123 X1143 SGTC_1700 st030840 7.9285 µM 0.721951736566508 0.27502250442965 no 935 0.235162075569036 1154 5499307 SGTC_260 nsc-65238 3.989 µM 0.720973738613644 0.27529356923072 no 936 0.23546283622444 1121 3246252 SGTC_1854 st056233 32.9 µM 0.720839562980535 0.275330768000719 no 937 0.23550411538986 1106 5393174 SGTC_1781 st038725 66.3 µM 0.717797234597201 0.27617488455965 no 938 0.23644115936977 1181 4270275 YIL048W NEO1 SGTC_3174 9107204 49.47 µM 0.714737530431138 0.277025101246191 no 939 0.237385621232377 1187 3938802 SGTC_1314 1222-0010 41.1 µM 0.713955413843604 0.27724263767275 no 940 0.237627375027206 1172 3526027 SGTC_1928 4'-methoxychalcone 40.3 µM 0.713424952225307 0.277390226801175 no 941 0.237791418624187 1196 641818 SGTC_2966 9084041 48.03 µM 0.710215211492247 0.278284084181403 no 942 0.238785344651722 1114 17741380 SGTC_877 0771-0151 33.1 µM 0.709924626673311 0.278365076301228 no 943 0.238875438990449 1165 6166523 SGTC_886 0866-0150 153 µM 0.708202213701672 0.278845384864274 no 944 0.239409845827258 1200 271463 SGTC_801 0866-0028 10.1 µM 0.707072598718366 0.279160605814226 no 945 0.239760681597116 1216 6849771 SGTC_1722 st034304 3.6505 µM 0.706588984464311 0.279295612116937 no 946 0.239910968202132 1199 4036148 YLR033W RSC58 SGTC_1430 4049-0248 69.1 µM 0.705946022313614 0.279475151272398 no 947 0.240110852846879 1221 22774488 SGTC_827 3253-0474 693 µM 0.705618274398469 0.279566692348851 no 948 0.240212778331726 1184 5402065 SGTC_527 4476-4215 268 µM 0.704615784228889 0.279846781491493 no 949 0.240524686492022 1137 4418754 SGTC_2511 berberine 10.47 µM 0.704534959191343 0.279869369401884 no 950 0.240549843462834 1181 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_896 0964-0007 44.5 µM 0.704306291821925 0.279933279117295 no 951 0.240621024444349 1180 6756758 SGTC_2569 tetrandrine 100 µM 0.704085297025602 0.279995051166791 no 952 0.240689827954448 1129 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_737 1950-0117 57.9 µM 0.703086899953766 0.280274203574612 no 953 0.241000797757629 1160 5393513 SGTC_1539 benzyladenosine 56 µM 0.70073326629639 0.280932813907132 no 954 0.241734745710662 1176 92208 A nucleotide analog. SGTC_2476 5806916 10.51 µM 0.700662282763316 0.28095268863323 no 955 0.241756899769051 1116 2870194 SGTC_2524 avocatin b 10.57 µM 0.699029188890467 0.281410127219223 no 956 0.242266894788224 1138 6710748 SGTC_3294 9122953 26.2835 µM 0.698676246835107 0.281509035443369 no 957 0.242377190803332 1205 16459826 SGTC_2635 hydroquinidine 100 µM 0.698334019039963 0.281604957122761 no 958 0.242484164538321 1168 442912 An experimental heart treatment. SGTC_126 0417-1624 672.48 µM 0.69552476137062 0.282392948064788 no 959 0.243363249511267 1288 41912 YDL195W SEC31 SGTC_1891 st059073 26.2 µM 0.695443779950289 0.282415678903675 no 960 0.243388616077858 1245 688754 SGTC_1033 k072-0102 21.3 µM 0.695302378179395 0.282455371362884 no 961 0.243432912100214 1178 5965931 SGTC_1187 1391-0724 117 µM 0.695247578371601 0.28247075477085 no 962 0.243450080054198 1228 6997986 SGTC_752 1896-0090 130 µM 0.695052238125439 0.28252559398346 no 963 0.243511282530961 1197 772567 SGTC_2096 5468907 200 µM 0.693693415277838 0.282907207263944 no 964 0.243937248162729 1205 759785 SGTC_2310 7668677 200 µM 0.69066908328434 0.2837574513578 no 965 0.244886761279768 1231 2197143 SGTC_219 mitoxanthrone 164.414 µM 0.690102776252929 0.283916795714093 no 966 0.245064778712686 1172 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_449 xestospongin c 11.1929 µM 0.68955261204689 0.284071638889732 no 967 0.245237788319985 1178 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_308 4092-1169 104 µM 0.687409528205184 0.28467519257539 no 968 0.245912347487534 1186 2268590 YDL196W YDL196W SGTC_2116 5511452 16.8835 µM 0.68654296132348 0.28491941627797 no 969 0.246185391380418 1201 870744 SGTC_2126 5251174 33.877 µM 0.68574813977592 0.285143507895658 no 970 0.246435972128339 1238 790722 SGTC_2275 7947463 200 µM 0.684362404142131 0.285534402339396 no 971 0.246873175069112 1178 1225414 SGTC_973 1325-0077 65.9 µM 0.6837600634704 0.285704392761001 no 972 0.247063344374826 1248 2835149 SGTC_1137 ixabepilone 100 µM 0.682563894152243 0.286042114038688 no 973 0.247441227813667 1228 154225 A novel microtubule stabilizer. SGTC_3064 1327-0027 10 µM 0.682210053748934 0.286142052155033 no 974 0.24755306917452 1111 16000455 YPR107C YTH1 SGTC_2108 5365811 200 µM 0.679602553219193 0.286879021422505 no 975 0.248378076287275 1238 780283 SGTC_810 3825-7150 143 µM 0.676001519224126 0.287898273662011 no 976 0.249519840247024 1259 22330411 YGL099W LSG1 SGTC_1103 duloxetine 36.1 µM 0.674039352908003 0.288454372507538 no 977 0.250143147443875 1295 60835 A selective serotonin reuptake inhibitor. SGTC_996 3970-0799 1.8 µM 0.673703607901035 0.288549576922216 no 978 0.250249883822385 1335 6615648 YGL040C HEM2 SGTC_2193 5925765 200 µM 0.672920813951086 0.288771604761893 no 979 0.250498834872912 1237 877370 SGTC_3180 9109287 49.47 µM 0.670849209259333 0.289359572328562 no 980 0.251158297586812 1222 18891271 SGTC_2258 7960471 200 µM 0.670809144752613 0.28937094907063 no 981 0.251171060536239 1184 2974708 SGTC_1365 1672-3266 55.4 µM 0.670246143678346 0.289530841425583 no 982 0.25135044643332 1234 6415873 SGTC_864 0469-0573 172 µM 0.668810369878584 0.289938789009261 no 983 0.251808225459565 1197 689425 SGTC_1981 st071826 47 µM 0.66818026482125 0.290117906335497 no 984 0.252009265687324 1204 11838600 SGTC_1045 1348-1485 165 µM 0.667904733483407 0.290196246767594 no 985 0.25209720284533 1265 6810614 SGTC_961 1252-1571 372 µM 0.667815165155466 0.290221715411787 no 986 0.252125792495934 1249 6813498 SGTC_1148 3909-7663 27.7 µM 0.666453996439892 0.290608890876708 no 987 0.25256047944248 1294 4084526 SGTC_2563 tomatine 8.54 µM 0.665844355091205 0.290782377655176 no 988 0.252755295326354 1244 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1217 1183-1422 255 µM 0.665360186713863 0.290920192846391 no 989 0.252910071650262 1265 2849664 SGTC_328 k915-0120 63.5 µM 0.664772775970537 0.29108743623635 no 990 0.253097918885634 1220 6624543 SGTC_669 0108-0021 26.2 µM 0.664700338783703 0.291108063144503 no 991 0.253121088551541 1343 17201 SGTC_2266 7929956 200 µM 0.664522475245943 0.291158713711919 no 992 0.253177984487787 1250 2967153 SGTC_865 0488-0499 301 µM 0.660951712788604 0.29217643659564 no 993 0.254321640418041 1266 9634651 SGTC_2979 9012552 45.46 µM 0.656090750752046 0.293564540681364 no 994 0.255882867606206 1312 17100905 SGTC_1955 wogonin 32.4 µM 0.654960085623274 0.293887852441657 no 995 0.256246726448871 1321 5281703 A flavanone. SGTC_2495 cafestol 54.53 µM 0.65464279006761 0.293978612147336 no 996 0.256348883637766 1277 16667697 An anti-infammatory. SGTC_790 1575-0012 79.1 µM 0.653961032421563 0.294173666971397 no 997 0.256568455637815 1285 378741 YLR208W SEC13 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.653767493576871 0.294229050454784 no 998 0.256630806061588 1237 688803 SGTC_1434 4073-0095 163 µM 0.653703761899459 0.29424728909999 no 999 0.256651339569023 1259 24133745 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.65341780087339 0.294329131467509 no 1000 0.256743482977058 1283 6708739 YPR165W RHO1 SGTC_2095 5432005 200 µM 0.652642694435092 0.294551020648423 no 1001 0.256993327186136 1258 783734 SGTC_3291 9121177 71.43 µM 0.65198491739046 0.294739382549143 no 1002 0.257205451150577 1219 17015612 SGTC_1443 4112-3303 14 µM 0.651472549672424 0.294886143316116 no 1003 0.257370745671166 1262 704433 SGTC_1574 spiramycin 23.7 µM 0.650879644015185 0.29505601510564 no 1004 0.25756209134369 1256 6419898 An antibiotic and protein synthesis inhibitor. SGTC_600 1495-0418 41.6 µM 0.649945027587481 0.295323881004622 no 1005 0.257863865692851 1275 5377768 SGTC_717 1532-0246 73.2 µM 0.64689694438263 0.296198254019643 no 1006 0.258849321782836 1258 9561992 SGTC_2246 7293507 91.5585 µM 0.644187541210448 0.296976468789316 no 1007 0.259726914449433 1290 887656 SGTC_244 nsc-207895 1.295 µM 0.642707606704131 0.297401941097725 no 1008 0.260206922145092 1180 42640 SGTC_1645 Cervolide 78 µM 0.638963978932818 0.298479452587911 no 1009 0.261423182659714 1221 23173 A fragrance. SGTC_4 0960-0234 25.671 µM 0.638502782258613 0.2986123195445 no 1010 0.261573221751642 1285 6821112 SGTC_1908 st060353 56.5 µM 0.638151409730702 0.298713565119259 no 1011 0.26168756189467 1326 4227716 SGTC_2655 perillic acid 100 µM 0.637691588574235 0.298846082987509 no 1012 0.261837231040818 1271 5702197 An apoptosis inducer. SGTC_137 0438-0332 85.389 µM 0.633765779230533 0.29997856503026 no 1013 0.26311684461424 1305 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2088 5278280 127.392 µM 0.633650135268225 0.300011954383441 no 1014 0.263154587037969 1315 791502 SGTC_106 0092-0003 11.579 µM 0.63081936233116 0.300829794297417 no 1015 0.264079320876113 1291 1072148 SGTC_2478 5763493 32.33 µM 0.628876264298391 0.301391757065405 no 1016 0.264715033200175 1266 1365576 YLR208W SEC13 SGTC_403 arphamenine a 50 µM 0.628718702196637 0.301437346257471 no 1017 0.264766615985862 1255 5487158 An arginine aminopeptidase inhibitor. SGTC_848 0368-0089 85.6 µM 0.62759302208385 0.301763142037492 no 1018 0.265135290514252 1273 762535 SGTC_2571 chrysanthemic acid 100 µM 0.626072779369555 0.302203383686954 no 1019 0.265633602793453 1248 2743 An insecticide. SGTC_2549 cedrol 20.94 µM 0.625916427595472 0.302248677381103 no 1020 0.265684879432799 1297 6708665 A sedative which affects the nervous system. SGTC_448 monastrol 171 µM 0.623770291777457 0.302870701125122 no 1021 0.266389226302771 1283 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3202 9113761 49.47 µM 0.621210417486867 0.303613388976105 no 1022 0.267230593016489 1375 4798415 SGTC_838 0109-0203 71.4 µM 0.618264223433934 0.304469163388038 no 1023 0.268200590556741 1304 759422 SGTC_909 3448-9333 149 µM 0.617898487507146 0.304575472746583 no 1024 0.268321128036973 1290 3344074 SGTC_2403 6032726 181.2 µM 0.61728289034332 0.304754447159876 no 1025 0.268524075089959 1316 2881040 SGTC_1352 1496-0991 99 µM 0.616701222410214 0.304923600171139 no 1026 0.268715907395639 1311 3000039 SGTC_27 0485-0001 32.618 µM 0.616463287451716 0.3049928053024 no 1027 0.268794397454613 1258 2054479 SGTC_2911 7942208 15.64 µM 0.614670726871498 0.305514408809072 no 1028 0.269386097828688 1286 1243384 SGTC_234 nsc-17383 10.7 µM 0.613204168925139 0.305941445153963 no 1029 0.269870674281876 1347 408974 SGTC_303 1348-1668 34.2 µM 0.612325159809565 0.306197523972508 no 1030 0.270161323309251 1334 5380509 SGTC_523 1934-0222 13.7 µM 0.612174617220057 0.306241390550517 no 1031 0.270211116713683 1321 1361595 SGTC_1011 4112-3381 17.4 µM 0.611514347984828 0.306433819086586 no 1032 0.27042956128496 1370 2877139 SGTC_980 1473-0395 201 µM 0.610186612790321 0.306820935160132 no 1033 0.270869098405536 1269 768876 SGTC_1299 1079-1439 3.74 µM 0.608282126500644 0.307376585730714 no 1034 0.271500186649247 1287 323161 SGTC_2183 6420625 130.508 µM 0.608015604114439 0.307454381289533 no 1035 0.271588562361585 1310 2897619 SGTC_3117 9124945 49.47 µM 0.607222172056248 0.307686028451783 no 1036 0.271851739939893 1236 17592065 SGTC_290 2043-6722 48.1 µM 0.605447028816314 0.308204569606756 no 1037 0.272441005505324 1334 773758 YLR208W SEC13 SGTC_543 3844-1095 191 µM 0.602441710742191 0.309083332723736 no 1038 0.273440076174936 1365 4230703 SGTC_1 0258-0098 57.368 µM 0.601097919882213 0.309476614933592 no 1039 0.273887384383812 1275 6790032 YDR047W HEM12 SGTC_3020 9089140 49.47 µM 0.600110576204141 0.309765716246149 no 1040 0.274216272260718 1347 17217859 SGTC_1808 st050063 61.5 µM 0.599398715877115 0.309974227096172 no 1041 0.274453516547884 1371 4011993 SGTC_1191 1487-1166 10.6 µM 0.5993113918505 0.30999980936823 no 1042 0.274482626318279 1423 3955771 SGTC_2717 st081029 62.2815 µM 0.597211107036899 0.310615381492904 no 1043 0.275183222266555 1307 5292846 SGTC_3062 9077494 49.47 µM 0.596338397240013 0.31087132001813 no 1044 0.275474592422972 1353 16459633 SGTC_882 0843-0131 351 µM 0.595595844940653 0.311089159489485 no 1045 0.275722626551645 1345 5425421 SGTC_177 1327-0068 8.361 µM 0.595508357112658 0.311114829789328 no 1046 0.275751857265159 1333 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_344 k064-0035 6.43 µM 0.59259161439693 0.311971173149991 no 1047 0.276727246209703 1309 5088750 SGTC_2249 haloperidol 116.36 µM 0.589628506301807 0.312842171055107 no 1048 0.277719867990036 1347 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_465 cgp-37157 41 µM 0.589523007730208 0.312873201394737 no 1049 0.277755241353533 1307 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3295 9122362 53.5725 µM 0.588647849228813 0.313130663238815 no 1050 0.278048764247446 1354 4730473 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.588110921071509 0.313288666614301 no 1051 0.278228921592598 1324 803109 SGTC_3230 9131665 49.47 µM 0.588065166324775 0.313302132579151 no 1052 0.278244276470977 1313 15943720 SGTC_282 k297-0036 65.7 µM 0.587719753480381 0.313403798199458 no 1053 0.278360207222518 1374 5061378 SGTC_849 0386-0493 241 µM 0.586802592659766 0.313673815623882 no 1054 0.278668147677072 1328 726119 SGTC_919 tnp00227 403.569 nM 0.586436134297405 0.313781731001096 no 1055 0.278791233914912 1383 1269246 A methoxyflavone. YNL221C POP1 SGTC_2194 5927483 104.545 µM 0.58601485908481 0.31390580863855 no 1056 0.278932764752552 1366 760979 SGTC_185 k048-0037 25.491 µM 0.583166480634918 0.314745289433957 no 1057 0.279890616740578 1373 6827589 SGTC_3140 9094243 49.47 µM 0.582618266333734 0.31490697054622 no 1058 0.280075152999604 1360 19291112 SGTC_3009 9080819 71.4286 µM 0.582341266738999 0.314988677645621 no 1059 0.280168417184948 1343 17027216 SGTC_2256 7954252 200 µM 0.581791687666674 0.315150814835528 no 1060 0.280353501860991 1312 2972920 SGTC_2490 carminic acid 95.39 µM 0.577618705853665 0.316383090887864 no 1061 0.281760787500704 1344 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3226 9131256 49.47 µM 0.576069585856444 0.316841064360985 no 1062 0.282284074003585 1285 17178073 SGTC_2150 5556613 200 µM 0.574387022068165 0.317338806587951 no 1063 0.282852966544711 1399 743190 SGTC_2419 paclitaxel 166.5 µM 0.570969360028403 0.318350848818468 no 1064 0.284010206345614 1303 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_548 1436-0017 110 µM 0.569993576825014 0.318640048324745 no 1065 0.284341027305117 1469 9677137 SGTC_3297 9117502 71.43 µM 0.567401974646048 0.319408675227828 no 1066 0.285220554304923 1366 7453720 SGTC_2949 9072542 2.23 µM 0.566039171841072 0.319813172103262 no 1067 0.285683576066498 1378 16457352 SGTC_837 0091-0265 12.5 µM 0.565783032858012 0.319889221295508 no 1068 0.285770640980362 1356 759367 SGTC_822 1487-0950 154 µM 0.565177449414819 0.320069052737107 no 1069 0.285976536708609 1403 1958375 SGTC_2697 mebhydrolin 72.4 µM 0.564977467392155 0.320128447823043 no 1070 0.286044545207053 1463 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_11 0438-0307 1.3 µM 0.564424498661218 0.320292704703943 no 1071 0.286232634970404 1443 4011476 SGTC_1287 0971-0001 34.6 µM 0.562339792445531 0.320912273776153 no 1072 0.286942265776076 1406 4665869 SGTC_2380 9035439 200 µM 0.560041826742397 0.321595801241386 no 1073 0.287725454181746 1472 6462575 SGTC_3157 9099274 49.47 µM 0.559040363279924 0.321893874727574 no 1074 0.288067086816117 1362 17217662 SGTC_1828 st055811 49 µM 0.558765627785703 0.321975666471 no 1075 0.288160841720887 1377 5877589 SGTC_1446 4239-0190 62 µM 0.557969431108266 0.322212751582158 no 1076 0.288432629228013 1381 1340085 SGTC_784 4579-0127 173 µM 0.556372173900458 0.322688588215562 no 1077 0.288978228588292 1525 1948547 SGTC_788 1182-0090 188 µM 0.555316900803076 0.323003122554705 no 1078 0.2893389603834 1545 5715185 SGTC_763 3453-1109 128 µM 0.555084723633526 0.323072342204053 no 1079 0.289418355609073 1402 1560353 SGTC_860 0443-0016 25.1 µM 0.552375546486054 0.323880489373251 no 1080 0.290345540462115 1417 5337942 SGTC_3214 9129694 49.47 µM 0.551338488639393 0.324190063717272 no 1081 0.290700829390451 1462 17158655 SGTC_2276 7947513 42.08 µM 0.547612202619437 0.3253034073896 no 1082 0.291979104396748 1266 2105100 SGTC_3004 9076122 71.4286 µM 0.547291206726146 0.325399388049648 no 1083 0.292089342004744 1462 44782551 SGTC_3353 9151644 39.2805 µM 0.544177328492789 0.32633106594506 no 1084 0.29315972573155 1401 4909158 SGTC_2799 7812892 81.82 µM 0.544014018372262 0.326379958607698 no 1085 0.293215913123444 1470 20205235 SGTC_1146 3579-1023 7 µM 0.543897715529743 0.326414779797411 no 1086 0.293255930548045 1529 X1146 SGTC_2811 7967822 32.47 µM 0.541893311156393 0.327015137999826 no 1087 0.293946002454549 1483 2232244 SGTC_2941 9056145 11.23 µM 0.539919700343813 0.327606710681413 no 1088 0.294626205582957 1348 2119517 SGTC_3238 9133470 49.47 µM 0.539319742288617 0.327786628788127 no 1089 0.294833124389856 1501 3534688 SGTC_1002 4049-0206 172 µM 0.538452642416881 0.328046729224906 no 1090 0.295132295726902 1415 4662749 SGTC_431 k089-0097 107 µM 0.537043061219064 0.328469733557128 no 1091 0.295618934908518 1367 5499420 SGTC_253 dyclonine 31.25 µM 0.536138613624617 0.328741267113264 no 1092 0.295931377562032 1482 3180 An oral anasthetic. SGTC_3258 9138477 49.47 µM 0.536134024361992 0.328742645133926 no 1093 0.295932963315635 1465 4970355 SGTC_2225 6654152 15.4 µM 0.535895101144951 0.328814389968542 no 1094 0.296015525180713 1449 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_335 4077-0256 27.6 µM 0.532888581522776 0.329717738339191 no 1095 0.297055354949335 1444 3121989 SGTC_2346 9031566 143.75 µM 0.530832139649074 0.330336196357305 no 1096 0.297767553076684 1503 4771086 SGTC_2734 clemastine 41.6 µM 0.529875596842954 0.330624026886411 no 1097 0.298099093375523 1445 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2726 cimetidine 79.27 µM 0.52949334351142 0.330739077661026 no 1098 0.298231630422186 1444 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2515 chrysin 20.77 µM 0.527975631100247 0.33119603711641 no 1099 0.298758124880589 1495 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_172 1112-0046 2.638 µM 0.527728349400792 0.331270513610586 no 1100 0.29884394691403 1451 2802135 YIL048W NEO1 SGTC_1288 0973-0013 65.5 µM 0.52399369813467 0.33239612892945 no 1101 0.30014146150733 1488 4315430 SGTC_2932 9016711 44.54 µM 0.523889420789892 0.332427579644186 no 1102 0.300177726693192 1535 7117328 SGTC_1300 1094-0077 113 µM 0.523316191555073 0.33260049031576 no 1103 0.30037711759029 1412 5532636 SGTC_265 mycophenolic acid 32.932 µM 0.52191056271421 0.333024639331274 no 1104 0.300866301783206 1502 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2224 6650123 117.647 µM 0.521416372049633 0.333173812347789 no 1105 0.301038374382416 1437 2908370 SGTC_1508 1080-0625 72.9 µM 0.521374904712204 0.33318633059557 no 1106 0.301052814941181 1424 767111 SGTC_1235 benzylparaben 21.5 µM 0.521352567252707 0.333193073952245 no 1107 0.301060593853016 1426 7180 SGTC_81 0411-0046 9.971 µM 0.520812201290611 0.333356219064885 no 1108 0.30124880127253 1371 12925265 SGTC_131 0141-0277 33.849 µM 0.519831858092769 0.333652280804335 no 1109 0.301590386304159 1513 1547771 SGTC_1275 0867-0008 21.1 µM 0.519823615606958 0.333654770458517 no 1110 0.301593259006025 1471 3422836 SGTC_1560 lithocholic acid 53.1 µM 0.51952324328701 0.333745503327609 no 1111 0.301697954282193 1433 9903 A bile acid which acts as a detergent. SGTC_3021 9087658 49.47 µM 0.519324140288157 0.333805651333109 no 1112 0.301767360971654 1449 25237042 SGTC_2693 st077581 40.7 µM 0.518679302379332 0.334000482899927 no 1113 0.301992198724096 1451 25238761 SGTC_3078 9116413 49.47 µM 0.517391677386243 0.334389660248367 no 1114 0.302441384133794 1382 17177322 SGTC_105 0111-0055 734.78 µM 0.516789256401437 0.334571799739699 no 1115 0.302651640313679 1437 5179370 SGTC_2022 5136654 200 µM 0.516313239158785 0.334715749126147 no 1116 0.302817825532391 1477 1713771 SGTC_3035 9091303 49.47 µM 0.515916422667532 0.334835766479175 no 1117 0.30295639172519 1465 25237002 SGTC_1975 st070967 30.8 µM 0.515628993271667 0.334922710186081 no 1118 0.303056778248835 1521 261391 SGTC_236 1509-0011 5.31 µM 0.515460469428309 0.334973690603001 no 1119 0.303115643180421 1484 3107280 SGTC_2783 7738165 71.43 µM 0.514985859357879 0.335117281991944 no 1120 0.303281450695507 1369 17201110 SGTC_956 1185-0240 191 µM 0.51352036896359 0.335560812301477 no 1121 0.303793683118826 1466 1416193 SGTC_89 0302-0250 142.109 µM 0.513299641664789 0.33562763524205 no 1122 0.303870867301317 1526 4203518 YLR208W SEC13 SGTC_1846 st056244 14.8 µM 0.512111590020993 0.335987395020557 no 1123 0.304286456749428 1495 5393182 SGTC_1122 capsaicin 818.572 nM 0.51209656694122 0.335991945196491 no 1124 0.304291713556613 1558 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1735 st034310 56.75 µM 0.510705589789731 0.336413347079557 no 1125 0.304778613010518 1567 871153 SGTC_2334 9017922 200 µM 0.509942450166732 0.336644630535258 no 1126 0.30504589043256 1599 3163164 SGTC_1841 st054148 70 µM 0.509755272357216 0.336701367644423 no 1127 0.305111462352405 1404 675442 SGTC_629 3448-6466 76.7 µM 0.509271368135579 0.336848065325497 no 1128 0.305281012128124 1462 573744 SGTC_478 N-arachidonylglycine 10 µM 0.508805363603337 0.336989360101603 no 1129 0.305444329731355 1457 5283389 SGTC_2240 6690706 185.951 µM 0.505435982625006 0.338011655735281 no 1130 0.306626325652774 1385 805876 SGTC_2379 9035213 200 µM 0.502458737692181 0.338915969877472 no 1131 0.307672435183506 1611 646551 SGTC_694 1315-0438 43.2 µM 0.50181383441842 0.339111976649654 no 1132 0.307899240354488 1511 6793154 SGTC_1486 3970-0793 4.53 µM 0.501164338099334 0.339309423416733 no 1133 0.308127735044272 1539 2844330 SGTC_2704 st078022 71.1 µM 0.500598655851649 0.339481426677785 no 1134 0.308326804311466 1583 54697681 SGTC_2990 9074105 71.4286 µM 0.498991483477993 0.339970291338695 no 1135 0.308892691901593 1494 6502001 SGTC_3339 9145883 14.936 µM 0.497226316831189 0.340507524414245 no 1136 0.309514732594536 1512 2030670 SGTC_1202 1988-0068 29.6 µM 0.496382234098489 0.340764537700481 no 1137 0.309812378551017 1427 2850480 SGTC_2558 carylophyllene oxide 100 µM 0.49598747852432 0.340884761522431 no 1138 0.309951622654053 1541 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2488 5268135 45.7 µM 0.493670592802926 0.341590700437906 no 1139 0.31076941840487 1565 1270356 YLR208W SEC13 SGTC_1219 1469-0211 33.1 µM 0.493248700239282 0.34171930790531 no 1140 0.310918435486757 1509 6822282 SGTC_108 0509-0257 621.132 µM 0.492892740187861 0.341827831151167 no 1141 0.311044188604855 1464 536624 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.492667488955463 0.341896511327122 no 1142 0.311123776476284 1464 2374 Ca(2+)-ATPase inhibitor. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.489297578062313 0.342924636851646 no 1143 0.312315517742323 1528 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1111 tnp00062 510.699 nM 0.488632670898217 0.3431276310163 no 1144 0.312550889317022 1622 676306 SGTC_1859 st055998 20 µM 0.488420608912147 0.343192382431203 no 1145 0.312625973576714 1637 676301 SGTC_2027 5150920 200 µM 0.487804072619191 0.343380662954765 no 1146 0.312844313213287 1550 786715 SGTC_615 k087-0205 167 µM 0.486400379228985 0.343809473869177 no 1147 0.313341660870287 1444 9642773 SGTC_2557 derrustone 83.84 µM 0.485286804692015 0.344149800094972 no 1148 0.313736457137727 1452 629853 An antioxidant. SGTC_1186 1319-0216 26 µM 0.484573594973394 0.344367834766418 no 1149 0.313989423952674 1617 4565136 SGTC_1081 sertraline 6 µM 0.484429448494727 0.3444119079372 no 1150 0.314040561581343 1573 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_569 4130-2812 160 µM 0.484421808977155 0.344414243799054 no 1151 0.314043271888113 1500 743552 SGTC_1482 3346-2049 8.48 µM 0.482065273418445 0.345135061869918 no 1152 0.314879788990397 1535 3826804 SGTC_1477 0139-0234 16 µM 0.480976733464308 0.345468214925737 no 1153 0.315266517443889 1542 620880 SGTC_1468 k284-1086 134 µM 0.479106175132686 0.34604098816422 no 1154 0.315931548469101 1510 15996457 SGTC_1822 st052468 42 µM 0.478990959882416 0.346076279118907 no 1155 0.315972529931247 1472 2873678 SGTC_2084 5306078 60.6385 µM 0.4777935590849 0.346443127519051 no 1156 0.31639857295176 1543 679340 SGTC_2594 a-mangostin 100 µM 0.477462594712548 0.34654455070292 no 1157 0.316516375264823 1623 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_127 0180-0333 59.125 µM 0.476965074213349 0.346697035282934 no 1158 0.316693496013713 1484 771601 SGTC_2115 tiliquinol 12.7705 µM 0.476925952346505 0.346709026760018 no 1159 0.3167074254528 1535 71208 A bioactive hydroxyquinoline. SGTC_714 4296-0578 26.1 µM 0.476848193907195 0.346732861419679 no 1160 0.316735112312337 1560 1589775 SGTC_903 1134-0042 114 µM 0.476618060616438 0.346803405852873 no 1161 0.316817060147957 1493 701009 SGTC_2345 9052315 157.45 µM 0.475799308441984 0.347054426965752 no 1162 0.31710868129912 1532 6469265 SGTC_1989 st071868 50.2 µM 0.475132756094091 0.347258834731848 no 1163 0.317346176200782 1629 16414057 SGTC_2465 5809242 33.21 µM 0.474918142804291 0.347324658412458 no 1164 0.31742265967032 1575 2731748 SGTC_2902 5787006 60.46 µM 0.470713525815986 0.348615176106783 no 1165 0.318922662047233 1501 591003 SGTC_2762 leflunomide 42.06 µM 0.470426607742213 0.348703303593125 no 1166 0.319025128974738 1554 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.469494648914495 0.348989613004689 no 1167 0.319358054421045 1487 390807 SGTC_98 0074-0023 107.663 µM 0.469280098930201 0.349055537626936 no 1168 0.319434719165693 1470 3563821 SGTC_514 4466-0038 2.65 nM 0.46702587637615 0.349748466058539 no 1169 0.320240682393703 1567 5722064 SGTC_2211 7117706 200 µM 0.459392415979461 0.352098632991511 no 1170 0.322976196717816 1592 822771 SGTC_1840 st055363 71 µM 0.457348103093487 0.352728994622829 no 1171 0.323710429923283 1475 676033 SGTC_1194 1488-0194 225 µM 0.456551159627644 0.35297484095571 no 1172 0.323996845466789 1550 1391452 SGTC_2589 lobaric acid 100 µM 0.454970399550336 0.353462665736374 no 1173 0.324565267132286 1498 73157 A novel microtubule depolymerizer. SGTC_944 3370-0224 231 µM 0.451526812557635 0.354526194282349 no 1174 0.325804952464805 1523 4580514 SGTC_2505 galangin 7.89 µM 0.450944462873832 0.354706161486103 no 1175 0.326014788355798 1494 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1919 st067113 52.3 µM 0.450425666457508 0.354866515741019 no 1176 0.326201770754698 1534 1268243 SGTC_1901 st060216 58.6 µM 0.450028597135604 0.354989262866804 no 1177 0.326344910315825 1530 688792 SGTC_1611 st001856 99.4 µM 0.446640455525684 0.35603725937819 no 1178 0.32756734038095 1514 647478 SGTC_638 3970-0837 4.09 µM 0.446341198763529 0.356129875844437 no 1179 0.327675400353635 1529 4118451 YLR208W SEC13 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.444666351602121 0.356648378010997 no 1180 0.328280444702611 1541 3256 An antibiotic and ribosome inhibitor. SGTC_2867 9039098 71.43 µM 0.444440223015283 0.356718403628316 no 1181 0.328362169008411 1524 6463460 SGTC_3096 9117468 49.47 µM 0.4415487579617 0.357614233371017 no 1182 0.32940788565871 1517 41316311 SGTC_208 k072-0098 12.366 µM 0.440973973705515 0.357792405931867 no 1183 0.329615919428853 1570 5948901 SGTC_2348 9022543 33.42 µM 0.438655639129459 0.358511361271377 no 1184 0.330455537495544 1595 3162678 YDL140C RPO21 SGTC_1337 1486-1011 40.3 µM 0.436789846465221 0.359090340162941 no 1185 0.331131881624205 1552 X1337 SGTC_1666 st014829 29 µM 0.432896088519432 0.360299663812471 no 1186 0.332545130887853 1546 3858230 SGTC_758 0868-0029 16 µM 0.432484537660893 0.360427565270606 no 1187 0.332694643927847 1709 762687 SGTC_483 fpl-64176 144 µM 0.432368272326885 0.360463700951538 no 1188 0.332736886989102 1593 3423 SGTC_3086 9117350 49.47 µM 0.431803060545847 0.360639388542131 no 1189 0.33294227746729 1522 2679265 SGTC_639 0833-0042 114 µM 0.430604999952497 0.361011884909433 no 1190 0.333377802518022 1550 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3120 9124077 49.47 µM 0.430432856706819 0.361065417863844 no 1191 0.333440399379824 1591 18774327 YGL155W CDC43 SGTC_2413 inermin 26.06 µM 0.429790660329739 0.361265151531465 no 1192 0.333673963707073 1722 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.429719535803373 0.361287274759989 no 1193 0.3336998353882 1711 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_270 tamoxifen 5.46 µM 0.429309468358564 0.361414834964566 no 1194 0.333849013616326 1712 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1479 0549-0158 134 µM 0.428627790419048 0.36162691948143 no 1195 0.334097058999317 1585 5440202 SGTC_1400 3771-8998 51.5 µM 0.428287594656671 0.361732777531999 no 1196 0.33422087476366 1635 670767 SGTC_933 2914-0560 114 µM 0.427667252472929 0.361925835432698 no 1197 0.334446697502752 1740 463887 SGTC_3048 9093155 49.47 µM 0.427386953609155 0.362013079317802 no 1198 0.334548754163518 1593 25236002 SGTC_804 1595-0054 20.9 µM 0.424923378854226 0.362780182550964 no 1199 0.335446265609547 1574 761523 Stimulates phospholipase C. SGTC_2328 6201408 200 µM 0.424408104813617 0.362940697384162 no 1200 0.335634105478392 1566 2890418 SGTC_845 0330-0138 4.51 µM 0.423990538341269 0.363070792655074 no 1201 0.335786356813456 1687 9039800 SGTC_3070 9117005 49.47 µM 0.419682091277355 0.364414034630357 no 1202 0.337358854788602 1656 8779016 SGTC_979 1426-2828 121 µM 0.41944988809037 0.364486475961577 no 1203 0.337443685399008 1682 747872 SGTC_2444 5485484 36.41 µM 0.414565587183939 0.366011368305083 no 1204 0.339229972256427 1685 6790631 SGTC_2657 nystatin 74.44 µM 0.413922461137698 0.36621231243165 no 1205 0.339465446874823 1645 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.413354508303532 0.366389799272452 no 1206 0.339673449652633 1589 2724 A muscle relaxant with antifungal properties. SGTC_2656 pseudo-anisatin 100 µM 0.410849761467528 0.367172880140866 no 1207 0.340591351174246 1639 6708809 A neurotoxin. SGTC_405 ebelactone b 50 µM 0.409892820420617 0.36747220311258 no 1208 0.340942286140311 1584 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2138 5575593 77.673 µM 0.409868390619794 0.367479845600252 no 1209 0.340951246981843 1574 762213 SGTC_3215 9129942 49.47 µM 0.409845852213421 0.367486896440791 no 1210 0.340959514140195 1713 17682944 SGTC_2774 tamoxifen 10.92 µM 0.409823894690267 0.367493765602706 no 1211 0.340967568302194 1620 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_985 1493-0307 8.71 µM 0.408395988462661 0.367940560793996 no 1212 0.341491489034007 1735 3278274 SGTC_1970 st070122 35.8 µM 0.408340785254335 0.367957837598936 no 1213 0.341511750080901 1656 102928 SGTC_659 k018-0002 107 µM 0.407068755358906 0.368356015422542 no 1214 0.3419787453219 1722 6797879 YHR007C ERG11 SGTC_2946 9065502 71.43 µM 0.405334115117987 0.368899229957525 no 1215 0.342615966539752 1563 16489101 SGTC_3026 9090633 49.47 µM 0.402975985470187 0.36963811450559 no 1216 0.343482945476686 1593 25236842 SGTC_1663 st014140 55.4 µM 0.402502258252789 0.369786608007949 no 1217 0.343657213368636 1699 4207120 SGTC_3352 9151559 45.5865 µM 0.402161750098494 0.369893354949865 no 1218 0.343782495095384 1576 17159339 SGTC_1561 5-methoxyflavone 52.9 µM 0.401863310553119 0.369986921919459 no 1219 0.343892312805533 1650 94525 SGTC_2617 dihydrotanshinone i 20.83 µM 0.401420097707141 0.370125892513416 no 1220 0.344055427491828 1591 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2262 9014885 67.46 µM 0.401164755691819 0.370205963397212 no 1221 0.344149413652235 1728 6457424 SGTC_2800 7887935 81.82 µM 0.400531537729886 0.370404553972493 no 1222 0.344382529732702 1658 2961002 SGTC_3060 1327-0027 12.5 µM 0.398709894349057 0.370976052416 no 1223 0.345053488255746 1724 16000455 YPR107C YTH1 SGTC_1916 st067606 49.2 µM 0.398467175228166 0.371052221443481 no 1224 0.345142924851633 1725 19590279 SGTC_624 k048-0052 28 µM 0.397628388546177 0.371315484603162 no 1225 0.34545206565432 1626 6835531 SGTC_3171 9103192 49.47 µM 0.397348210899422 0.371403435107311 no 1226 0.345555350105576 1686 13018434 SGTC_2243 6634756 200 µM 0.397288104315986 0.37142230402678 no 1227 0.345577509244067 1727 885676 SGTC_2076 5212012 200 µM 0.396810972157305 0.371572098382797 no 1228 0.345753429500803 1627 604802 SGTC_3075 9116269 49.47 µM 0.395716704510042 0.371915714184458 no 1229 0.346157015465728 1642 17015205 YNL244C SUI1 SGTC_2072 5231554 129 µM 0.395110133170974 0.372106230299911 no 1230 0.346380805421303 1779 789545 SGTC_2038 4100038 30.985 µM 0.393600326050198 0.372580576828015 no 1231 0.346938070231993 1661 3596803 SGTC_2156 5649887 115 µM 0.393241437590377 0.372693359759246 no 1232 0.34707058354428 1730 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_358 0075-0058 9.45 µM 0.393158845289735 0.372719316448912 no 1233 0.347101081960485 1875 1069125 SGTC_3112 9123419 49.47 µM 0.391960175917825 0.37309609319316 no 1234 0.347543819571896 1653 17015854 SGTC_699 0375-0592 111 µM 0.39141646586893 0.373267037163726 no 1235 0.34774471162055 1709 762578 SGTC_1074 carmofur 3.8 µM 0.386967326676604 0.374666793577992 no 1236 0.349390198372711 1658 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2358 9037157 4 µM 0.384682157752721 0.375386380885995 no 1237 0.350236457951824 1685 2388925 SGTC_2364 9055074 200 µM 0.384600765819805 0.375412018779731 no 1238 0.350266613324436 1589 6470630 SGTC_191 3914-0123 66.505 µM 0.38453140578235 0.375433867144209 no 1239 0.350292311674806 1604 3144412 SGTC_722 3534-0461 190 µM 0.384499269991902 0.375443990031721 no 1240 0.350304218429024 1615 658262 SGTC_836 0330-0104 1.35 µM 0.384195842804189 0.375539574894571 no 1241 0.350416649644257 1681 46494820 SGTC_3197 9113331 49.47 µM 0.383521630575561 0.375751990861627 no 1242 0.350666517606272 1751 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_595 3909-8003 73.7 µM 0.383321113644458 0.375815172596969 no 1243 0.35074084311241 1668 699517 SGTC_844 0330-0132 15.3 µM 0.382901164132862 0.375947507067693 no 1244 0.350896524087481 1717 2828079 SGTC_1158 4092-0494 91.8 µM 0.381614983618324 0.376352898923456 no 1245 0.351373484289921 1739 1148199 SGTC_321 4534-3890 65.3 µM 0.381278827354374 0.376458874685783 no 1246 0.351498181279994 1771 699746 SGTC_323 4013-0906 34.3 µM 0.381217539422336 0.376478197166147 no 1247 0.351520917729329 1763 2910086 SGTC_455 paf C-16 10 µM 0.379931678949984 0.376883666608835 no 1248 0.351998065527743 1657 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_179 1273-0063 6.77 µM 0.378362337267887 0.377378709982254 no 1249 0.352580721347671 1602 3108139 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.377673430719361 0.377596086863102 no 1250 0.352836603838236 1789 6728940 SGTC_1399 3562-5772 25 µM 0.376644272693007 0.377920898569885 no 1251 0.353218990892242 1642 23847490 SGTC_2525 harmine 47.85 µM 0.376619777303218 0.377928630592095 no 1252 0.353228094042662 1731 5280953 A monoamine oxidase inhibitor SGTC_1760 st045453 10.4495 µM 0.375112238558066 0.378404582427624 no 1253 0.353788497726139 1753 3323419 YIL048W NEO1 SGTC_500 h-89 112 µM 0.374633789754981 0.378555674262151 no 1254 0.353966419820223 1806 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1882 5615643 20 µM 0.373995743408951 0.378757195120833 no 1255 0.354203741519906 1633 2253075 SGTC_12 0849-0099 9.267 µM 0.371656580043141 0.379496279184386 no 1256 0.355074278470193 1745 6071388 SGTC_968 1309-0633 340 µM 0.371541299344337 0.379532714785468 no 1257 0.355117200645264 1764 3761976 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.371231849891059 0.379630524624454 no 1258 0.355232426278113 1695 66535 A nucleotide analog. SGTC_1665 st014639 11.4 µM 0.369484604319918 0.38018293303315 no 1259 0.355883273294317 1736 981133 YIL048W NEO1 SGTC_2780 5215298 71.43 µM 0.369367117745777 0.380220086323141 no 1260 0.355927052011811 1824 2834131 SGTC_1340 1486-1359 257 µM 0.36883350531234 0.380388846807059 no 1261 0.356125914531857 1683 4309068 SGTC_3031 9088762 49.47 µM 0.368713240737671 0.380426884875263 no 1262 0.356170739202447 1614 205253 SGTC_3163 9099914 49.47 µM 0.368395076298403 0.380527521584843 no 1263 0.356289334131984 1718 16268368 SGTC_1669 st015249 58.4 µM 0.367846958114814 0.380700912561828 no 1264 0.35649367629153 1799 722793 SGTC_583 1488-1091 88.9 µM 0.367726987524511 0.380738867096675 no 1265 0.356538407635779 1805 4303273 SGTC_2669 eugenol 100 µM 0.365592380904052 0.381414374187297 no 1266 0.35733463063503 1779 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_664 1222-0054 14.9 µM 0.365401931195174 0.381474660554165 no 1267 0.357405699941208 1680 6813991 SGTC_2781 5567276 71.43 µM 0.363953138817862 0.381933366113487 no 1268 0.357946501379276 1741 2853274 SGTC_2892 9047358 58.44 µM 0.363908908300374 0.381947372653004 no 1269 0.357963016123372 1662 6466771 SGTC_982 1491-0518 27.5 µM 0.362924448346333 0.382259162920659 no 1270 0.358330661495743 1694 3091256 SGTC_573 3702-0553 84.7 µM 0.362384437149301 0.382430223383861 no 1271 0.358532383837968 1688 1222756 SGTC_3304 9125678 46.087 µM 0.361190670737728 0.382808456621022 no 1272 0.35897845787373 1649 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3308 9128332 17.569 µM 0.356635430417865 0.384252764329915 no 1273 0.360682374865612 1814 17332805 YDL196W YDL196W SGTC_949 1165-0505 146 µM 0.356335667365333 0.38434786536002 no 1274 0.360794600656045 1660 6244267 SGTC_463 ikarugamyin 104 µM 0.354770579997988 0.384844508545355 no 1275 0.361380735160456 1734 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1295 1013-0063 9.78 µM 0.351640223850664 0.385838418822824 no 1276 0.362554047566034 1825 6826038 SGTC_56 0957-0365 83.25 µM 0.351382031690073 0.385920430230617 no 1277 0.362650880343201 1724 6752360 SGTC_1945 st075991 56.6 µM 0.349996174606195 0.386360716897191 no 1278 0.36317078426744 1662 1084980 SGTC_3016 9080866 49.47 µM 0.349551560027999 0.386502001944347 no 1279 0.363337634795638 1650 17066299 SGTC_130 0136-0219 337.655 µM 0.349277383341135 0.386589134493369 no 1280 0.363440538019116 1838 234244 SGTC_2864 9034755 47.6 µM 0.3480535626407 0.386978130797161 no 1281 0.363899979036851 1780 4930451 SGTC_680 0417-1641 114 µM 0.347889681459837 0.387030229715183 no 1282 0.363961517414023 1686 2835990 SGTC_868 0527-0199 213 µM 0.347265996277682 0.387228521990256 no 1283 0.364195747053821 1699 2849450 SGTC_925 2064-1272 59.6 µM 0.34697044709257 0.387322498140142 no 1284 0.364306760485905 1674 6815817 SGTC_2814 7977482 42.97 µM 0.345304264079652 0.387852419873135 no 1285 0.3649328206648 1821 6456762 SGTC_3246 9135460 32.98 µM 0.343535100626309 0.388415322751427 no 1286 0.36559796960225 1775 41446951 SGTC_2603 homopterocarpin 100 µM 0.343399495686968 0.388458478487478 no 1287 0.365648969436073 1700 101795 A weak amylase inhibitor. SGTC_2187 6125751 200 µM 0.343199728509381 0.388522056110505 no 1288 0.365724104453684 1724 874498 SGTC_3032 9089427 49.47 µM 0.342606470102895 0.388710883301434 no 1289 0.365947266963927 1694 17173707 SGTC_2400 5203494 178.7 µM 0.342506276281986 0.388742776416126 no 1290 0.365984960761156 1657 6777674 SGTC_2738 aclarubicin 5.55 µM 0.341854315638827 0.38895032304496 no 1291 0.366230265671934 1772 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2541 muurolladie-3-one 83.07 µM 0.341653499046122 0.389014257841837 no 1292 0.36630583538757 1748 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3138 9097216 49.47 µM 0.340711783596113 0.389314115693739 no 1293 0.366660283439294 1792 25237486 SGTC_2763 lisinopril 49.32 µM 0.338979499255155 0.389865875867817 no 1294 0.367312587021862 1796 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1893 st059353 36.1 µM 0.338478670413529 0.390025439257005 no 1295 0.367501249043761 1681 3112488 SGTC_394 menadione 8.33 µM 0.337118655884139 0.390458831460503 no 1296 0.368013727202062 1812 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_679 0422-0091 41.4 µM 0.33675528003992 0.390574650541561 no 1297 0.368150693635428 1653 627384 YHR062C RPP1 SGTC_1963 st076565 50.3 µM 0.333847275827234 0.391501870073776 no 1298 0.369247403525627 1698 4914280 SGTC_772 k072-0172 35.3 µM 0.331482687313849 0.392256276018488 no 1299 0.370139958011424 1637 5861980 SGTC_1655 st012546 55.1 µM 0.330386115507951 0.39260626750348 no 1300 0.370554115655993 1749 720985 YLR208W SEC13 SGTC_2434 5670830 169.91 µM 0.328468707801192 0.393218452762168 no 1301 0.371278650258007 1737 1549830 SGTC_3318 9139014 38.6185 µM 0.328090413284861 0.393339264957898 no 1302 0.371421651134922 1742 16643984 SGTC_951 1171-0579 82.7 µM 0.327306107486351 0.393589773690011 no 1303 0.37171818675975 1672 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1259 0671-0132 43 µM 0.326964933598407 0.393698759019872 no 1304 0.371847203855489 1724 X1259 SGTC_715 0868-0130 184 µM 0.32674926620327 0.393767656578731 no 1305 0.371928767290956 1888 2876258 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.325939687860318 0.394026315831932 no 1306 0.37223499367067 1805 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2624 nerol 100 µM 0.324932154037392 0.394348286896449 no 1307 0.372616210387524 1822 637566 A natural product oil. SGTC_162 k030-0015 37.8 µM 0.323374922605526 0.394846063233907 no 1308 0.373205659515035 1889 1809920 YMR134W ERG29 SGTC_1930 st074634 34.3 µM 0.323321583251707 0.394863116454649 no 1309 0.37322585499519 1660 684253 YOR116C RPO31 SGTC_2970 9090938 41.86 µM 0.322806366667987 0.395027847640076 no 1310 0.373420945514823 1897 17217104 SGTC_1262 0737-0114 49.6 µM 0.322548136916011 0.39511041899478 no 1311 0.37351873830557 1878 765919 SGTC_2130 NSC 7 2.4545 µM 0.321333055274707 0.395499015773517 no 1312 0.373979004536958 1856 21448 SGTC_3257 9139206 32.98 µM 0.320828714413156 0.395660340196502 no 1313 0.374170098897836 1823 4910041 SGTC_2801 7907800 81.82 µM 0.319410848567024 0.396113971203776 no 1314 0.374707492692511 1717 6620925 SGTC_1563 conessine 56.1 µM 0.318933930685996 0.396266587632439 no 1315 0.374888306944103 1872 441082 An anti-amoebic, histamine inhibitor. SGTC_3105 9121040 49.47 µM 0.317947083979427 0.396582434638512 no 1316 0.375262538210947 1848 41448907 SGTC_2806 7952793 58.44 µM 0.316972444677076 0.396894441202368 no 1317 0.375632255465442 1781 2972490 SGTC_475 α-linolenic acid 10 µM 0.315572693961022 0.397342652062856 no 1318 0.376163433190513 1834 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1464 k208-0027 110 µM 0.315021978890691 0.397519032431416 no 1319 0.376372483055488 1864 X1464 SGTC_1203 3992-3522 103 µM 0.314993029319913 0.397528304840454 no 1320 0.376383473233661 1954 5322312 SGTC_1087 pterostilbene 9.05 µM 0.31440501547209 0.39771665538805 no 1321 0.376606723679056 1868 5281727 Similar to reservatol, lowers cholesterol. SGTC_14 0354-0009 295 µM 0.312262061280932 0.398403280505265 no 1322 0.377420685091739 1808 1713507 SGTC_396 dithiazanine 1.25 µM 0.312197776363929 0.398423882942156 no 1323 0.377445110959796 1733 10578 An antihelmenthic. SGTC_616 4092-0450 108 µM 0.310173321013538 0.399072837767281 no 1324 0.37821457873152 1799 787165 SGTC_1348 1493-0373 93.8 µM 0.309683312809604 0.3992299557023 no 1325 0.378400896902807 1794 3010129 SGTC_1674 st016616 23.6 µM 0.307364495628434 0.399973690319978 no 1326 0.379282974705065 1659 625830 SGTC_3241 9133421 49.47 µM 0.306939733227081 0.400109967513293 no 1327 0.379444622555469 1789 17018221 SGTC_156 3474-0145 5.642 µM 0.302929656306546 0.401397124173781 no 1328 0.380971735056923 1918 2265471 SGTC_47 0149-0135 24.25 µM 0.301222163016205 0.4019455221351 no 1329 0.381622545284567 1650 5239155 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.298615188865902 0.402783179760396 no 1330 0.382616837458862 1868 688662 SGTC_2029 5175081 200 µM 0.295014091293246 0.403940996857432 no 1331 0.383991557617032 1777 1380876 SGTC_634 1611-4317 11.2 µM 0.294947378117775 0.403962454309036 no 1332 0.384017039229603 1920 2843522 SGTC_99 0109-0120 622.8 µM 0.294820751072776 0.404003183096006 no 1333 0.384065406786305 1867 759414 SGTC_91 0417-1751 58.384 µM 0.291017258828886 0.405227035476814 no 1334 0.385519059934033 1834 6795624 SGTC_2446 5162541 200 µM 0.290577404104408 0.405368627889736 no 1335 0.385687271820917 1751 1549321 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.28976085303992 0.405631514400636 no 1336 0.385999599169176 1722 23665772 A membrane-active detergent. SGTC_2007 4011539 71.82 µM 0.289052437965776 0.405859621299525 no 1337 0.386270624836354 1737 45595301 SGTC_935 2996-0153 430 µM 0.288655108812305 0.405987573739383 no 1338 0.386422659454926 1961 23738523 SGTC_1628 st004252 77.7 µM 0.288431789121241 0.406059494088327 no 1339 0.386508118490154 1905 692968 SGTC_3205 9113483 49.47 µM 0.287680416960709 0.406301497572313 no 1340 0.386795690807815 1902 17018033 SGTC_454 lyso-paf C-16 6.67 µM 0.287435486747741 0.406380392938105 no 1341 0.386889446277045 1706 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3267 9137951 49.47 µM 0.286394866153851 0.406715633383027 no 1342 0.387287853161258 1813 16643986 SGTC_2056 5235370 200 µM 0.285297940352176 0.407069086815729 no 1343 0.387707945339049 1770 5511916 SGTC_2833 9001315 45.46 µM 0.285092528597499 0.407135283389252 no 1344 0.387786626978353 1781 2989378 SGTC_317 4495-0002 170 µM 0.283701537622461 0.407583617788389 no 1345 0.388319558138441 1769 15991618 SGTC_32 0928-0142 34.1 µM 0.280930721819888 0.408477047836906 no 1346 0.389381768266827 1897 2244242 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.280518952840584 0.408609860574645 no 1347 0.389539693340829 1757 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2849 9019321 12.99 µM 0.279863779975658 0.408821202888901 no 1348 0.389791008299051 1812 16489627 SGTC_1436 4092-1007 8.32 µM 0.279483767235515 0.408943797609631 no 1349 0.389936796884918 1825 2881121 SGTC_2106 5357045 167.29 µM 0.277639395804298 0.409538930835306 no 1350 0.390644593559353 1878 668842 SGTC_1354 1498-1681 81 µM 0.277293427107748 0.409650589677033 no 1351 0.390777403083974 1825 5754243 SGTC_3351 9150312 21.596 µM 0.276397565354015 0.409939756478086 no 1352 0.391121363241626 1878 4904905 SGTC_1931 st074438 57.1 µM 0.275859237786601 0.410113541749593 no 1353 0.391328091515598 1852 2787313 SGTC_1156 4092-0367 4.88 µM 0.274792519485268 0.410457956563718 no 1354 0.391737822766718 1839 1357585 SGTC_1603 st002045 67.8 µM 0.271895154402655 0.411393786105206 no 1355 0.392851318580641 1936 5887985 SGTC_1671 st016596 74.5 µM 0.271809346201836 0.411421509295962 no 1356 0.392884309231898 1823 2829167 SGTC_1620 st003704 16.5 µM 0.271064089597657 0.41166230779489 no 1357 0.393170870136097 1945 2834414 SGTC_2041 5107442 45.335 µM 0.27046560968397 0.411855705639837 no 1358 0.393401035405708 1940 793005 SGTC_3019 9081971 49.47 µM 0.270193848540202 0.411943531899076 no 1359 0.393505562458397 1952 16451803 SGTC_1634 st006576 41 µM 0.268256788295138 0.412569667807273 no 1360 0.39425083274316 1981 3915356 SGTC_1061 3448-9325 110 µM 0.267678146849652 0.412756751276233 no 1361 0.394473536221395 1953 723482 SGTC_3270 9137563 49.47 µM 0.266359124727533 0.413183284952681 no 1362 0.394981321078383 1904 17015724 SGTC_2028 5153890 36.43 µM 0.264758778715454 0.413700928228087 no 1363 0.395597646885633 1825 2830968 YPR165W RHO1 SGTC_2288 7946289 167.31 µM 0.264735159918518 0.413708569021041 no 1364 0.395606744924337 1936 1246052 SGTC_1431 4049-0260 9.09 µM 0.264694204571766 0.41372181834762 no 1365 0.395622521194219 1901 3854841 SGTC_72 0744-0168 198.391 µM 0.264088549578417 0.413917763217724 no 1366 0.395855843447307 1855 677577 SGTC_3350 9150499 3.57 µM 0.263685420358252 0.414048197707846 no 1367 0.396011165457368 1844 4910996 YPR165W RHO1 SGTC_2782 7736369 71.43 µM 0.263608445183117 0.414073104492086 no 1368 0.396040825168075 1799 2950836 YOL077C BRX1 SGTC_588 3970-1144 52.9 µM 0.262902015340271 0.414301699452549 no 1369 0.396313051462199 1925 1888707 SGTC_1865 st057639 52.2 µM 0.262690165482424 0.414370258008537 no 1370 0.396394698731797 1896 688818 SGTC_2918 7977171 22.06 µM 0.261679755541881 0.414697281328365 no 1371 0.396784174776073 1828 2236483 SGTC_1388 3346-4487 254 µM 0.26114411201522 0.414870668547863 no 1372 0.39699068754257 1897 3345614 SGTC_2994 9053520 71.4286 µM 0.257627095945764 0.416009533216873 no 1373 0.398347357942895 1950 4647384 SGTC_2496 diffractaic acid 79.83 µM 0.256166268108822 0.416482780035625 no 1374 0.398911226966425 1976 94870 An apoptosis inducer which activates caspases. SGTC_1044 1222-0021 1.78 µM 0.255960955192143 0.416549302511692 no 1375 0.398990493214653 1896 4306703 SGTC_36 0335-0881 14.2 µM 0.254717633727597 0.416952196267882 no 1376 0.399470597819498 1863 23828853 SGTC_2412 st077135 33.4 µM 0.254249351335754 0.417103964096146 no 1377 0.399651463028028 1917 13258915 SGTC_554 4483-2211 187 µM 0.253898311028994 0.417217742491689 no 1378 0.399787059825409 1865 747107 SGTC_998 3996-0085 177 µM 0.253502865759338 0.417345921627181 no 1379 0.399939823460993 1944 715391 SGTC_2872 9044037 25.97 µM 0.249615448803205 0.418606449656963 no 1380 0.401442375148261 1938 6465195 SGTC_1638 st008370 60.6 µM 0.247402801565512 0.419324293643973 no 1381 0.402298253116516 1887 24207134 SGTC_958 1222-0007 33 µM 0.24592125659462 0.419805098118079 no 1382 0.40287159432922 1918 7312461 SGTC_3255 9139072 49.47 µM 0.245190136000366 0.420042412202263 no 1383 0.403154606828472 1885 17646060 SGTC_2760 etidronate 98.04 µM 0.243866435932626 0.420472145290267 no 1384 0.403667132362738 1846 3305 A chelator and antioxidant. SGTC_1116 jasmonic acid  1.58368 µM 0.240795039034839 0.421469624411899 no 1385 0.404856987394112 1950 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1787 fluconazole 80 µM 0.240032451858332 0.421717363645036 no 1386 0.40515254947171 1898 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2882 9058044 58.44 µM 0.238579586175076 0.422189437101592 no 1387 0.405715797972069 1790 18076804 SGTC_1867 st057372 64 µM 0.236317228773874 0.422924757623967 no 1388 0.40659325943628 1947 688837 SGTC_2313 7726885 200 µM 0.235085373240011 0.423325253388496 no 1389 0.407071235536248 1885 726423 SGTC_144 4161-2749 112.381 µM 0.234887984941674 0.423389434829982 no 1390 0.407147837670748 1931 797501 YMR168C CEP3 SGTC_1097 itavastatin 7.23 µM 0.23254474253622 0.424151502498796 no 1391 0.408057469990614 1905 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_586 0957-0265 8.15 µM 0.229973417531591 0.424988073396565 no 1392 0.409056212938411 2026 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1885 st057546 99.9 µM 0.229971934708532 0.424988555925309 no 1393 0.409056789061176 1984 702008 SGTC_705 1124-0212 310 µM 0.229298669528333 0.42520765624152 no 1394 0.409318393749721 2017 9554485 SGTC_2900 5328528 85.29 µM 0.228386118262521 0.425504664162133 no 1395 0.409673040164666 1894 795359 SGTC_1662 st014054 52 µM 0.228305203816224 0.425531001417543 no 1396 0.409704489661182 2008 2838777 SGTC_1775 st081588 35.1725 µM 0.227278307308328 0.425865280023202 no 1397 0.410103670009976 1952 1426443 YGL099W LSG1 SGTC_2040 5100729 123 µM 0.226014479487668 0.426276758379162 no 1398 0.410595079345363 1938 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1163 k060-0048 49.9 µM 0.225958821605824 0.426294881377905 no 1399 0.410616723819456 1883 6809982 SGTC_1504 k297-0033 30 µM 0.22470243656366 0.42670401957493 no 1400 0.411105384488589 1827 4388117 SGTC_2079 5212404 121 µM 0.224686370217738 0.426709252046257 no 1401 0.411111634257246 2047 758462 SGTC_343 4130-2827 29.8 µM 0.224245849915136 0.426852725275906 no 1402 0.411283004345394 1845 1118244 SGTC_1873 rapamycin 2 nM 0.223892507988154 0.42696781234184 no 1403 0.411420472760605 1889 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2427 5545055 42.75 µM 0.223356874175744 0.427142285584532 no 1404 0.411628882948722 1918 5372858 SGTC_440 fluspirilene 35.1 µM 0.223142858214474 0.427212001486476 no 1405 0.411712161565195 1974 3396 An atypical antipsychotic. SGTC_2174 5790901 200 µM 0.222821635381297 0.427316644394428 no 1406 0.411837164346584 1903 786020 SGTC_578 3460-0051 92 µM 0.221618292308883 0.42770869592504 no 1407 0.412305520683245 2035 2876744 SGTC_3317 9138495 8.753 µM 0.221128582748517 0.427868264718697 no 1408 0.412496157634269 1985 17020139 SGTC_3250 9135583 49.47 µM 0.221046528553983 0.427895002718859 no 1409 0.412528102183105 2035 7699353 SGTC_1076 itraconazole 331 nM 0.219559109695054 0.428379747053744 no 1410 0.413107270014807 2019 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_613 3914-0030 117 µM 0.218362635118364 0.428769752191209 no 1411 0.413573287957605 1962 1145395 SGTC_495 decylubiquinone 155 µM 0.216371781474507 0.429418848639077 no 1412 0.414348980202843 1884 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.216279817850194 0.429448837016652 no 1413 0.41438481990048 1914 689007 SGTC_2922 7999257 32.47 µM 0.215230583855829 0.429791010045417 no 1414 0.414793773588519 1955 2988377 SGTC_2369 9071472 200 µM 0.214703792401448 0.429962825592061 no 1415 0.414999132812507 1948 17296037 SGTC_2202 7226349 200 µM 0.213874031513454 0.430233482953349 no 1416 0.415322645762187 1935 844334 SGTC_1496 4469-0713 57.4 µM 0.213571285068664 0.430332243130865 no 1417 0.415440696960589 2007 746691 SGTC_516 3992-2719 87.3 µM 0.213275261601643 0.430428814392007 no 1418 0.415556134020797 1806 5350887 YDR037W KRS1 SGTC_572 0960-0087 17.7 µM 0.211659565051793 0.430955973675342 no 1419 0.416186317872532 1883 6796365 SGTC_2470 5664817 21.68 µM 0.210154907393457 0.431447014554937 no 1420 0.416773386148975 1990 2859561 SGTC_184 1494-0393 24.714 µM 0.20984616663145 0.431547784378313 no 1421 0.416893869709578 1863 3090647 SGTC_96 0929-0093 37.281 µM 0.208422476500312 0.432012519796731 no 1422 0.41744955397642 1896 6991579 SGTC_2750 bromebric acid 70.15 µM 0.208209650635306 0.432082000681396 no 1423 0.417532636798776 1932 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1615 st002656 86.5 µM 0.207350577944133 0.432362481959748 no 1424 0.417868038422605 1994 1584458 SGTC_505 gw-5074 63.9 µM 0.206975405670895 0.432484983809054 no 1425 0.418014533016257 2011 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1457 k015-0032 57.3 µM 0.206881906749895 0.432515514236658 no 1426 0.418051043579703 1913 4302660 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.203782474826398 0.43352780617201 no 1427 0.419261744268103 1968 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1439 4092-1168 46 µM 0.203112223839785 0.433746771514822 no 1428 0.419523658812989 2003 2886240 SGTC_2344 7990960 76.95 µM 0.201178130135793 0.434378737378676 no 1429 0.420279645757395 1923 140813 SGTC_3034 9090421 49.47 µM 0.199990179190583 0.434766984063002 no 1430 0.42074413092044 2049 17173761 SGTC_3128 9127691 49.47 µM 0.199733395321268 0.434850914569387 no 1431 0.420844547150965 1971 41316314 SGTC_1948 st076329 66.6 µM 0.198994340529459 0.435092493010452 no 1432 0.421133585833975 2059 24208413 SGTC_3327 9140648 26.9345 µM 0.198931712055158 0.435112965799931 no 1433 0.42115808130782 2044 8029710 SGTC_782 0083-0095 30.5 µM 0.198171711346816 0.435361418311563 no 1434 0.421455359810202 2010 3591729 An indicator and reagent. SGTC_1154 4088-0362 150 µM 0.197267752282464 0.435656965598036 no 1435 0.421809006712592 2024 6618304 SGTC_204 PMA1.184 62.41 µM 0.195881845979274 0.436110154133733 no 1436 0.422351323407735 2008 2252213 YGL008C PMA1 SGTC_3334 9142812 21.919 µM 0.195651254921448 0.436185565095903 no 1437 0.422441569926457 2004 45283678 SGTC_2497 7-hydroxyflavone 100 µM 0.193057432919357 0.437033990525804 no 1438 0.423456994532412 2058 5281894 SGTC_1982 st072467 71.9 µM 0.192908371143713 0.437082756681525 no 1439 0.423515364475683 1927 3163533 SGTC_456 gingerol 170 µM 0.192707017214778 0.43714863194195 no 1440 0.423594213761965 1991 442793 A herb. SGTC_2353 9059630 146.67 µM 0.192342937889332 0.437267749115678 no 1441 0.423736793341816 2036 4779114 SGTC_859 0439-0102 54.6 µM 0.192320841250762 0.437274978737443 no 1442 0.423745447078246 2089 610143 SGTC_2374 9071832 200 µM 0.191652701515009 0.43749359189353 no 1443 0.424007128894934 2067 17381698 SGTC_74 000s-0487 160.283 µM 0.188701215036717 0.438459536157054 no 1444 0.425163499618092 2121 677548 SGTC_3333 9141820 12.094 µM 0.188028260127231 0.438679828228477 no 1445 0.425427248946782 1940 1939433 SGTC_3136 9095672 49.47 µM 0.187328842978423 0.438908802857472 no 1446 0.425701404914973 2126 17217380 SGTC_2092 5303694 80.6725 µM 0.187288615375855 0.438921973160484 no 1447 0.425717174334282 1936 1963699 SGTC_533 1222-0222 6.71 µM 0.186241026850292 0.439264971837131 no 1448 0.426127875982014 2061 3982874 SGTC_2537 larixol 68.93 µM 0.185608870747229 0.439471972803774 no 1449 0.426375748300703 1989 6708759 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.183417096513261 0.440189802125769 no 1450 0.427235381168505 2080 688801 SGTC_601 0986-0029 62.9 µM 0.183249744023688 0.440244619951951 no 1451 0.427301032520739 1982 24747981 SGTC_1613 st002381 52.1 µM 0.182522951543061 0.440482700697567 no 1452 0.427586172076006 2120 551167 SGTC_1338 1486-1223 76 µM 0.179546510291601 0.441457938990829 no 1453 0.428754300346285 2052 3444526 SGTC_1716 st033144 30.6155 µM 0.178994869192113 0.441638724728131 no 1454 0.428970865212843 2100 674617 SGTC_2605 digitonin 300 nM 0.177477483375192 0.442136070289045 no 1455 0.429566675068802 2124 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2944 9067346 25.62 µM 0.176998688463577 0.442293021347248 no 1456 0.429754709884253 2006 6473075 SGTC_1230 0170-0365 3.77 µM 0.175006947812068 0.442946019556368 no 1457 0.430537087137515 2097 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1372 2752-0194 270 µM 0.173857789772916 0.44332284513122 no 1458 0.430988613112286 2042 823334 SGTC_851 0394-0702 453 µM 0.173744236252631 0.443360083764715 no 1459 0.431033235350095 2117 762646 SGTC_1094 duloxetine 25.4 µM 0.173052972813645 0.44358678681932 no 1460 0.43130489470335 1995 60834 A selective serotonin reuptake inhibitor. SGTC_2098 5376439 882.5 nM 0.172263253163736 0.443845801637811 no 1461 0.431615286089941 2070 2844116 SGTC_232 clozapine 119 µM 0.172076525701788 0.443907048628727 no 1462 0.431688683625606 2015 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2719 novobiocin 32.65 µM 0.170619936754086 0.444384858669398 no 1463 0.432261310265966 2084 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1726 st035556 14.5795 µM 0.167295363332501 0.445475732006595 no 1464 0.433568826126449 2079 5919439 SGTC_1591 genipin 88.4 µM 0.167026223040263 0.445564061656211 no 1465 0.433674707873192 2098 442424 A DNA cross-linking agent. SGTC_1454 4239-0054 42.6 µM 0.166721197393961 0.445664171852863 no 1466 0.433794712932735 2103 1340767 SGTC_2227 7312221 64.1025 µM 0.164535397071491 0.446381658091549 no 1467 0.434654841803317 2098 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3269 9137823 49.47 µM 0.164157014222721 0.446505879684823 no 1468 0.434803769828061 1959 17682936 SGTC_3 0833-0587 95.581 µM 0.161097718234876 0.447510426226819 no 1469 0.436008218678977 2040 5382644 SGTC_1748 st037455 53.6035 µM 0.160918949692018 0.447569136915717 no 1470 0.436078618557395 2025 580690 SGTC_1647 st011722 22.4 µM 0.159816354854125 0.447931273521468 no 1471 0.436512870183561 2076 2854783 SGTC_1444 4112-3581 28 µM 0.159779987965495 0.447943218615166 no 1472 0.436527194412667 2029 2877249 SGTC_1038 k292-0204 154 µM 0.159349823496904 0.448084514316253 no 1473 0.436696634364972 2016 4454212 SGTC_2055 5235184 200 µM 0.158649443172108 0.448314581639774 no 1474 0.436972536029367 2039 2836034 SGTC_2218 6965428 192.983 µM 0.158427164223079 0.448387601496263 no 1475 0.437060105058628 2091 675684 SGTC_3071 9117417 49.47 µM 0.157838727356527 0.448580914676617 no 1476 0.437291940561495 2139 45595590 YGL055W OLE1 SGTC_1294 1000-1494 117 µM 0.157147121799968 0.448808136422098 no 1477 0.437564450538105 1977 712797 YDL207W GLE1 SGTC_3054 9094397 49.47 µM 0.156393431465726 0.449055774767458 no 1478 0.437861457200319 2034 2598354 SGTC_614 0462-0418 107 µM 0.1562619924515 0.449098963425103 no 1479 0.437913256947222 2089 5188303 SGTC_2491 paeonol 100 µM 0.156216570140049 0.449113888575783 no 1480 0.437931158000191 2008 11092 Increases levels of cortical cytochrome oxidase. SGTC_2636 apigenin dimethyl ether 100 µM 0.154491625317736 0.449680734963452 no 1481 0.438611056988043 2051 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2730 imipramine 71.33 µM 0.153437900004662 0.450027057735421 no 1482 0.439026479427506 2147 3696 A tricyclic antidepressant. SGTC_3156 9099931 49.47 µM 0.15319858004228 0.450105719176401 no 1483 0.439120838708476 2035 18111053 SGTC_59 0330-0160 1.33 µM 0.151448892462963 0.45068087868691 no 1484 0.439810811805326 2074 4293482 SGTC_3261 9137475 49.47 µM 0.150392586769352 0.451028159049163 no 1485 0.440227444827465 2155 17027690 SGTC_2071 5230951 39.92 µM 0.149913640447891 0.451185634028541 no 1486 0.440416374908701 2119 1799272 SGTC_1898 st060199 18.6 µM 0.148531817829865 0.451640012860357 no 1487 0.440961538720716 2045 688866 SGTC_1276 0871-0068 94.2 µM 0.146826546755805 0.452200837150174 no 1488 0.441634465241867 2111 3414906 SGTC_3220 9131269 49.47 µM 0.143745780022411 0.453214271289184 no 1489 0.442850609671016 2168 17722206 SGTC_1021 4476-0760 85.3 µM 0.143120385674541 0.453420035421648 no 1490 0.443097552619849 1956 746768 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.142205243498118 0.453721153464672 no 1491 0.443458945085603 2163 551469 SGTC_874 0599-0792 117 µM 0.140667183237146 0.454227296091862 no 1492 0.444066435623525 2177 765305 SGTC_371 0195-0006 7.36 µM 0.14055656329878 0.454263701615148 no 1493 0.444110132471215 2066 3928593 SGTC_729 4092-0585 94.1 µM 0.138531411168464 0.454930255961873 no 1494 0.444910223206107 2024 2169061 SGTC_2591 skatole 100 µM 0.138062551247384 0.455084593699617 no 1495 0.44509549103065 2060 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2665 lovastatin 100 µM 0.137540023847421 0.455256605505585 no 1496 0.445301979439799 2066 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1290 0986-0249 10.2 µM 0.13728672711502 0.455339991767963 no 1497 0.445402080662706 2173 53329 SGTC_1827 berberine 7.24 µM 0.13300175618086 0.456750916003012 no 1498 0.447095995804476 1943 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2598 perillyl alcohol 100 µM 0.131558645415964 0.457226216737069 no 1499 0.447666698654681 2100 10819 An apoptosis inducer. SGTC_2895 9054447 58.44 µM 0.131220651002865 0.457337546924405 no 1500 0.447800380034808 2059 2697450 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.131188827716323 0.457348029200588 no 1501 0.447812966882413 2172 1377 SGTC_1298 1079-1278 263 µM 0.129346436136333 0.457954945137204 no 1502 0.448541764646616 2084 2840950 SGTC_363 0455-0021 3.06 µM 0.127883051769766 0.458437079422059 no 1503 0.449120761819209 2117 4597466 SGTC_754 3474-0146 171 µM 0.127672854633553 0.45850633711191 no 1504 0.449203936559259 1974 24762078 SGTC_945 3381-0768 11.3 µM 0.124995160503043 0.459388717971535 no 1505 0.450263690825748 2183 1126236 YIL048W NEO1 SGTC_1093 fluphenazine 7.97 µM 0.124637271748562 0.459506668348607 no 1506 0.450405359933893 2115 6602611 An atypical antipsychotic. SGTC_2337 9009472 200 µM 0.123657047334777 0.459829741812778 no 1507 0.450793410908123 2179 5742383 SGTC_2954 9074818 52.69 µM 0.123627121709964 0.459839605457483 no 1508 0.450805258598157 2122 16648742 SGTC_1739 st037196 92.5 µM 0.12231981720124 0.460270524000355 no 1509 0.451322868994684 2182 612214 SGTC_54 0159-0055 9 µM 0.121489306435814 0.460544304300039 no 1510 0.451651742096942 2203 3319099 SGTC_706 4262-0057 46.9 µM 0.119418521730672 0.461227025712066 no 1511 0.452471894037979 2164 883298 SGTC_2253 7938677 135.83 µM 0.118994320948067 0.461366895539668 no 1512 0.452639927520621 2204 2301972 SGTC_3124 9127567 49.47 µM 0.117988007680603 0.461698721798195 no 1513 0.453038579996041 2209 17592030 SGTC_1398 3558-0053 112 µM 0.117248306960156 0.461942651053726 no 1514 0.453331643728243 2105 4532369 SGTC_1455 4262-0120 131 µM 0.117077319735233 0.461999039123398 no 1515 0.453399391173377 2159 1529587 SGTC_746 1095-0025 46.6 µM 0.11628121438606 0.462261588331104 no 1516 0.453714836678102 2183 6749286 SGTC_2653 dihydrofissinolide 100 µM 0.115143036563807 0.462636978850217 no 1517 0.454165874242147 2135 6857746 SGTC_2821 7996764 71.43 µM 0.113711920064262 0.463109032745957 no 1518 0.454733081485897 2134 2987135 SGTC_1162 k048-0130 20.1 µM 0.113129740389815 0.463301079663264 no 1519 0.454963848459609 2071 6797406 SGTC_987 1497-1013 404 µM 0.1129833014962 0.463349387641236 no 1520 0.455021896956268 2195 1676435 SGTC_1404 3909-7820 48.3 µM 0.112846745847987 0.463394435772889 no 1521 0.455076028591814 2208 23741373 SGTC_890 0929-0006 47.2 µM 0.112151562860341 0.463623775878908 no 1522 0.455351617011454 2036 1378169 SGTC_3178 9107506 49.47 µM 0.111700604982977 0.463772552857921 no 1523 0.455530399813222 2166 8897194 SGTC_2702 st077768 96.8 µM 0.111578490847609 0.463812840801785 no 1524 0.455578813662507 2091 6484119 SGTC_1753 st043925 64 µM 0.111362159887074 0.463884213708641 no 1525 0.455664582702993 2196 670181 SGTC_1475 4092-1048 11.7 µM 0.110779871587697 0.464076330714664 no 1526 0.455895453619748 2111 2881759 SGTC_1254 0550-0035 264 µM 0.108610694589535 0.464792090438683 no 1527 0.456755638941644 2162 15121435 SGTC_2453 5731132 22.18 µM 0.10840539680753 0.464859838144402 no 1528 0.456837060166559 2197 1362040 SGTC_1025 k007-0731 70 µM 0.105868521817108 0.465697083399078 no 1529 0.457843334812718 2098 6256118 SGTC_2575 plumbagin 510 nM 0.105400828748754 0.465851452904846 no 1530 0.458028879241083 2111 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1247 0448-0043 5.84 µM 0.104805171946676 0.466048066304277 no 1531 0.458265203017228 2110 3089013 YGL099W LSG1 SGTC_428 3448-4153 16.5 µM 0.104071020182719 0.466290405284653 no 1532 0.458556494247129 2062 3834874 SGTC_2206 7254556 146.969 µM 0.103787219229623 0.466384089587833 no 1533 0.458669104633817 2213 4398905 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.103276690922091 0.466552622561429 no 1534 0.458871687315913 2248 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2371 9071574 200 µM 0.102439933044675 0.466828861715883 no 1535 0.459203744194772 2218 45596039 SGTC_1183 1254-0324 198 µM 0.101998294638214 0.466974666399642 no 1536 0.459379014353459 2186 5799357 SGTC_352 k048-0007 5.11 µM 0.0990725828111948 0.467940686348497 no 1537 0.460540320357389 2217 6811911 SGTC_2300 7976697 71.57 µM 0.0989403886536481 0.467984339097062 no 1538 0.460592800352756 2136 2236109 SGTC_1659 st012954 42.1 µM 0.0983246250937001 0.468187679712731 no 1539 0.460837262461891 2187 24207262 SGTC_281 1672-3440 14.9 µM 0.0960992126335953 0.46892263570342 no 1540 0.461720888320833 2198 6833000 SGTC_3090 9117696 49.47 µM 0.0944120301552256 0.469479908695822 no 1541 0.462390929905172 2225 7923821 SGTC_815 1582-0027 36.9 µM 0.0943589184268222 0.469497452369752 no 1542 0.462412024248916 2173 3128206 SGTC_257 daunorubicin 18.5 µM 0.0940472522402729 0.469600402008881 no 1543 0.462535810593542 2221 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_389 tpck 16.7 µM 0.093105283573569 0.46991156561883 no 1544 0.462909959993468 2145 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1193 1488-0126 41.5 µM 0.0919129413432487 0.470305462278509 no 1545 0.463383604641344 2248 1384710 SGTC_1527 coumarin 137 µM 0.0915024004017512 0.470441093427824 no 1546 0.463546699497472 2176 323 A hepatotoxic, DNA x-linker. SGTC_3025 9087895 49.47 µM 0.0896284136018226 0.471060249133421 no 1547 0.464291252241248 2254 17173641 SGTC_2274 7947094 46.08 µM 0.089504803575144 0.471101091733257 no 1548 0.464340368103424 2264 2971028 SGTC_1015 4130-4525 82 µM 0.088656761507414 0.471381305677643 no 1549 0.464677348240063 2053 1363237 SGTC_2519 cryptotanshinone 88.04 µM 0.0886477619377332 0.471384279432901 no 1550 0.464680924468079 2237 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_547 1120-0019 610 nM 0.0876509471126786 0.471713669833475 no 1551 0.465077054013212 2223 3676939 SGTC_777 1315-0167 517 µM 0.0869563715632888 0.471943198857378 no 1552 0.46535309556962 2071 4221767 SGTC_857 0438-0306 1.35 µM 0.0868369234643818 0.471982672546436 no 1553 0.465400568891602 2169 4686136 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0861755296113985 0.472201246548096 no 1554 0.465663441435737 2169 4174840 SGTC_2689 tacrolimus 100 µM 0.085670884280439 0.472368024747562 no 1555 0.465864023994243 2167 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_64 000l-0018 272.079 µM 0.0847910717542035 0.472658802008742 no 1556 0.466213745843241 2143 6811119 SGTC_256 clotrimazole 625 nM 0.0846420077221938 0.472708068987155 no 1557 0.466273000772955 2241 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_413 propylparaben 100 µM 0.0840515215687193 0.472903233968869 no 1558 0.46650773418434 2136 7175 A pharmaceutical preservative. SGTC_2165 5727197 32.143 µM 0.083461337638602 0.473098305561103 no 1559 0.466742359095653 2153 1361712 SGTC_1080 nisoldipine 24.4 µM 0.083361055996583 0.473131451971578 no 1560 0.466782226752905 2255 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2367 9070478 135.38 µM 0.0828991476425784 0.473284130409225 no 1561 0.466965865896249 2233 572802 SGTC_2733 amorolfine 100 µM 0.0817649589009566 0.473659039919229 no 1562 0.467416810742239 2272 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0811143679883672 0.473874105259697 no 1563 0.467675499669313 2272 88881 An O-methylated flavonoid and antioxidant. SGTC_1562 morin hydrate 59.1 µM 0.0805446723627463 0.474062435362442 no 1564 0.467902034106916 2190 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1711 st032263 62.8 µM 0.0804721409497682 0.474086413229452 no 1565 0.467930876330648 2182 3958979 SGTC_2154 5570129 200 µM 0.0801914618227008 0.474179202692731 no 1566 0.468042490385851 2257 673366 SGTC_198 3454-2873 16.191 µM 0.0787098895805872 0.474669017437254 no 1567 0.468631689569827 2200 710957 SGTC_926 2268-1401 59.4 µM 0.0785143559109013 0.474733664663397 no 1568 0.468709455554482 2277 2931578 SGTC_312 4092-0653 6.84 µM 0.0776421396686577 0.475022044359657 no 1569 0.469056360463955 2229 1148278 SGTC_2606 farnesol 9.78 µM 0.0768352349792507 0.475288841840684 no 1570 0.469377310059922 2253 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2968 9090663 33.37 µM 0.0761145700745555 0.475527134101705 no 1571 0.469663974262399 2136 25236811 SGTC_3047 9092122 49.47 µM 0.0756831325880898 0.475669795741269 no 1572 0.469835597872632 2200 17173831 SGTC_1385 3091-4834 14.1 µM 0.0754340419088923 0.475752162941765 no 1573 0.469934687415804 2208 4072814 SGTC_3290 9121031 71.43 µM 0.073594771031628 0.476360389332099 no 1574 0.470666415984901 2216 17014854 SGTC_986 1493-0483 84 µM 0.0727715716482456 0.476632630125749 no 1575 0.47099394674869 2279 40079 SGTC_346 4513-0042 7.16 µM 0.0726804003588634 0.476662782114266 no 1576 0.471030222770617 2270 2827372 SGTC_745 0469-0705 296 µM 0.0725147893550653 0.476717552999589 no 1577 0.471096118125264 2272 3486736 SGTC_1947 st076332 61.6 µM 0.0713176353568871 0.477113488889991 no 1578 0.471572479990893 2278 24208416 SGTC_2641 levomentholum 100 µM 0.0711594588324397 0.477165804461958 no 1579 0.471635423374735 2258 16666 SGTC_3247 9135149 49.47 µM 0.0710276491273319 0.477209399728017 no 1580 0.47168787511815 2291 8934436 YOR116C RPO31 SGTC_2761 levamisole 97.89 µM 0.0708054568210988 0.477282889112153 no 1581 0.471776294406265 2293 26879 An alkaline phosphatase inhibitor. SGTC_1905 st060207 84.5 µM 0.0690360656280507 0.477868136871429 no 1582 0.472480455874559 2133 1948547 SGTC_1550 gossypolone 36.6 µM 0.068405121863551 0.478076840841976 no 1583 0.472731572362691 2280 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3243 9134147 49.47 µM 0.0659647991252891 0.478884108395918 no 1584 0.473702925308956 2300 24282180 SGTC_2836 9010338 19.48 µM 0.0632130702724687 0.47979449396673 no 1585 0.474798418511633 2230 2994051 SGTC_442 cape 100 µM 0.0628759388604647 0.479906038307692 no 1586 0.47493264746622 2283 5281787 SGTC_3093 9117344 49.47 µM 0.0628184281951246 0.479925066621528 no 1587 0.474955545636277 2228 24824913 SGTC_2066 5222451 176 µM 0.0624014696428526 0.48006302532314 no 1588 0.475121562318488 2294 2281147 SGTC_2201 6605497 169.863 µM 0.0605745053946283 0.480667539280688 no 1589 0.475849038988311 2266 670741 SGTC_350 k064-0020 19.8 µM 0.0591036067067182 0.481154269075278 no 1590 0.476434792964724 2309 2790705 SGTC_2984 9022109 38.96 µM 0.0578304702298619 0.481575580797568 no 1591 0.476941833526477 2306 6459207 SGTC_1192 1488-0095 21.4 µM 0.0568172276235102 0.481910902067116 no 1592 0.477345395223575 2213 915875 SGTC_2373 9071805 200 µM 0.0553165619177985 0.482407553984519 no 1593 0.477943133932794 2325 10149009 SGTC_181 1447-1644 8.07 µM 0.0550853991717202 0.482484060758351 no 1594 0.478035214127725 2305 534600 SGTC_136 0097-0015 404.482 µM 0.054371141311203 0.482720459160686 no 1595 0.478319735365469 2317 4861337 SGTC_1502 4534-4282 27.7 µM 0.0540963991383479 0.482811392383974 no 1596 0.478429180559998 2239 3278949 SGTC_60 0986-0278 202 µM 0.0530498950907491 0.483157768857898 no 1597 0.478846076559857 2219 3110598 SGTC_2644 guaiazulene 100 µM 0.0522438946379663 0.483424551082162 no 1598 0.479167178902357 2291 3515 A coloring agent. SGTC_3095 9117207 49.47 µM 0.0521134610874456 0.483467724652893 no 1599 0.479219143572355 2307 17015229 SGTC_3208 9114115 49.47 µM 0.0510307309983403 0.483826116291725 no 1600 0.479650516323539 2189 650895 SGTC_1946 st076057 65.1 µM 0.0504340853093974 0.484023616014982 no 1601 0.479888237394289 2328 953009 SGTC_636 0kpi-0074 126 µM 0.0496866994672538 0.484271018780102 no 1602 0.4801860278279 2256 616434 SGTC_1227 3909-8010 46.6 µM 0.0493097520368168 0.484395799787072 no 1603 0.480336223985877 2257 15982272 SGTC_1424 4048-1941 275 µM 0.0480313023216679 0.484819016640308 no 1604 0.480845647871708 2316 X1424 SGTC_2481 5478948 45.16 µM 0.0480181864894015 0.484823358583161 no 1605 0.48085087430121 2266 77792 SGTC_116 0155-0182 31.788 µM 0.0467628234772788 0.48523894964889 no 1606 0.481351129584008 2201 771486 SGTC_1821 st053465 65.6 µM 0.046671182715752 0.485269288185671 no 1607 0.481387649085114 2276 675086 SGTC_2267 7931562 200 µM 0.0462671248317357 0.485403056366288 no 1608 0.48154867090996 2297 934880 SGTC_1848 st056003 16.4 µM 0.0445128804982386 0.485983838723761 no 1609 0.482247792500681 2343 146492 SGTC_1688 st021091 57.6 µM 0.0441389792249487 0.486107631102652 no 1610 0.48239681105955 2336 3656366 SGTC_2431 5490079 200 µM 0.0439630188050081 0.486165889081474 no 1611 0.482466941034356 2303 5722345 SGTC_3116 9124943 49.47 µM 0.0435727987809642 0.486295086402927 no 1612 0.482622467262915 2300 41905195 YPL160W CDC60 SGTC_3254 9136651 49.47 µM 0.0435188742663027 0.486312940297372 no 1613 0.482643959644742 2334 16454030 SGTC_357 1325-0123 420 µM 0.0421064767149818 0.486780581369584 no 1614 0.483206908539863 2322 1098503 SGTC_1374 2889-5571 141 µM 0.0395672651506939 0.48762135285171 no 1615 0.484219062808552 2292 2853281 SGTC_68 0986-0284 82.829 µM 0.0387493423097903 0.487892191411963 no 1616 0.484545116725863 2112 423278 YIL048W NEO1 SGTC_398 bronopol 33.3 µM 0.0387485010948065 0.48789246996614 no 1617 0.484545452070236 2262 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2934 9036370 36.88 µM 0.0375781886151141 0.488280004896126 no 1618 0.485011999300094 2314 6462800 SGTC_552 k242-0005 476 µM 0.0368557272201309 0.48851924486263 no 1619 0.485300020152041 2294 4088318 SGTC_3212 9128307 49.47 µM 0.0360459955874778 0.488787388896564 no 1620 0.485622841795062 2217 27243542 SGTC_1010 4112-3296 15.2 µM 0.0359296119376366 0.488825929963404 no 1621 0.485669242096948 2344 704384 SGTC_2622 2-methoxyxanthone 59.94 µM 0.0344505881166907 0.489315725562346 no 1622 0.486258921953071 2331 71034 A hepatoprotective. SGTC_619 1652-1634 108 µM 0.0343652129090485 0.489343999034599 no 1623 0.486292961577305 2310 5400454 SGTC_2046 4110841 106 µM 0.0343103171329436 0.489362178745793 no 1624 0.486314848916117 2351 44119630 YMR134W ERG29 SGTC_1380 2291-0730 164 µM 0.0324650197012804 0.489973294381462 no 1625 0.487050605775409 2306 2999191 SGTC_2671 danthron 100 µM 0.0320711057567313 0.490103751771235 no 1626 0.487207672909086 2322 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1749 st037932 54.2 µM 0.0320387885580873 0.490114454707811 no 1627 0.48722055898396 2299 594497 SGTC_652 0437-0092 114 µM 0.0315931495561561 0.490262043902494 no 1628 0.487398253263353 2344 3091274 SGTC_3122 9126309 49.47 µM 0.0313227596682001 0.490351593775473 no 1629 0.487506069860514 2358 17591206 SGTC_441 propafenone 146 µM 0.0308638635065333 0.490503575765714 no 1630 0.487689054464519 2347 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1050 3232-1156 69.3 µM 0.0297530373787428 0.490871476348594 no 1631 0.488132006455247 2313 700529 SGTC_1977 st070720 65.3 µM 0.0296818950461257 0.490895038634913 no 1632 0.488160375610087 2249 682188 SGTC_1131 3454-3128 32.3 µM 0.0285521083605349 0.491269227327745 no 1633 0.48861090424333 2290 710982 SGTC_384 k007-0144 5.16 µM 0.0274666942039161 0.491628726948573 no 1634 0.489043751997326 2318 6824886 SGTC_2720 fluspirilene 36.88 µM 0.0270454565686826 0.491768246757339 no 1635 0.489211739089014 2347 3396 An atypical antipsychotic. SGTC_2873 9040596 71.43 µM 0.0267093256267627 0.491879578759707 no 1636 0.489345787506225 2228 6463863 SGTC_2017 5132927 60.65 µM 0.0264611031729562 0.491961794456095 no 1637 0.489444778949287 2351 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1829 berberine 14.4 µM 0.0259791182645624 0.492121437411827 no 1638 0.489636997020138 2361 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1980 st071811 45.7 µM 0.0257824667182181 0.492186572665997 no 1639 0.489715423366368 2322 4974850 SGTC_984 1492-0255 2.91 µM 0.0244679091509173 0.492621987889263 no 1640 0.490239690417771 2328 1585198 SGTC_2341 7987486 176.74 µM 0.0229041170904012 0.49313996738317 no 1641 0.490863378147499 2356 1258686 SGTC_1621 st003705 32.4 µM 0.0226591522839784 0.493221108874513 no 1642 0.490961079608787 2359 24207032 SGTC_3100 9120536 49.47 µM 0.0224158840237751 0.493301688683981 no 1643 0.491058104958379 2375 16421196 SGTC_3125 9127534 49.47 µM 0.0221589336789116 0.493386800823166 no 1644 0.491160587858372 2371 1639235 SGTC_2506 ethyl hematommate 54.16 µM 0.0220328284844695 0.493428571972483 no 1645 0.491210884272623 2271 3940691 An allergen. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0202845422759349 0.494007682415172 no 1646 0.491908193364052 2350 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3319 9138450 16.7555 µM 0.0199816889460636 0.494108002276123 no 1647 0.492028989877184 2344 2029690 SGTC_114 0364-0001 490.298 µM 0.0189024249787818 0.494465510365938 no 1648 0.492459472517032 2311 4003655 SGTC_2437 5741531 144.16 µM 0.0188874324481816 0.49447047670007 no 1649 0.492465452603783 2368 2262990 SGTC_1003 4049-0218 100 µM 0.0188080278363796 0.494496779801152 no 1650 0.492497124834609 2354 295161 SGTC_2786 7743617 45.45 µM 0.0186872022766297 0.494536803805816 no 1651 0.492545318788734 2350 583674 SGTC_1177 0983-0204 23.6 µM 0.0185774521840798 0.49457315906033 no 1652 0.49258909514147 2375 766818 SGTC_716 1683-5115 658 µM 0.0179869227149569 0.494768775599099 no 1653 0.492824642943257 2385 723597 SGTC_2695 st077686 51.995 µM 0.0179258395499839 0.494789009847854 no 1654 0.492849007672086 2356 2876092 SGTC_974 1326-0144 138 µM 0.0176256731650457 0.494888442369774 no 1655 0.492968737816233 2351 5411856 SGTC_889 0919-1524 82.7 µM 0.0166088439475679 0.495225277525089 no 1656 0.493374334541178 2330 3905452 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0155203602097543 0.495585852744746 no 1657 0.493808520675155 2373 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1731 st035964 63 µM 0.0153435383652862 0.495644427762704 no 1658 0.49387905398584 2297 6739575 SGTC_142 0335-0849 62.6745 µM 0.0151275135785861 0.495715989499378 no 1659 0.493965225405013 2378 3889043 YPR107C YTH1 SGTC_287 k060-0039 29.6 µM 0.0150859926409198 0.495729744003574 no 1660 0.493981787972556 2381 5861974 SGTC_1301 naphtanilide LB 4.81 µM 0.0148465901627303 0.495809050172128 no 1661 0.494077285047123 2379 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_912 3474-0017 2.18 µM 0.011461172353735 0.496930544028738 no 1662 0.49542775386589 2385 3360550 SGTC_1820 st053765 18.6 µM 0.0109833649072927 0.497088830376592 no 1663 0.495618359453607 2368 3690829 SGTC_1145 3546-0597 10.2 µM 0.00984146156421016 0.497467117855792 no 1664 0.496073888258037 2358 875334 SGTC_276 colchicine 750 µM 0.00916188374107835 0.497692248154671 no 1665 0.496344988341315 2344 2833 A microtubule depolymerizer. SGTC_981 1488-1094 54.9 µM 0.00898575259655831 0.497750596940222 no 1666 0.496415251609075 2385 3449522 SGTC_950 1165-0508 94.1 µM 0.00513425560235148 0.499026532036554 no 1667 0.497951737360737 2383 6148369 SGTC_2482 5981709 142.65 µM 0.00448269926004478 0.499242382853846 no 1668 0.498211667724147 2399 877755 SGTC_2466 5983409 37.09 µM 0.00432037334323918 0.499296159025796 no 1669 0.498276425768196 2377 2879657 SGTC_1630 st005209 31.3 µM 0.00288685563016985 0.499771062656057 no 1670 0.498848312831392 2399 3367314 SGTC_368 fentichlor 4.58 µM 0.00273403051665802 0.499821691430936 no 1671 0.498909280989838 2399 7329 A pesticide. SGTC_2137 5261020 140 µM 0.00237395431954436 0.499940979536252 no 1672 0.499052930139753 2400 763655 SGTC_103 0844-0104 51.839 µM 0.00230491695938508 0.499963850629345 no 1673 0.499080471986274 2397 5375804 SGTC_2140 5586273 200 µM 0.00224432217951818 0.499983924816061 no 1674 0.499104645743395 2403 854421 SGTC_2881 9058953 51.95 µM 0.00214727493731233 0.499983924816061 no 1675 0.499143361898156 2395 17122249 SGTC_861 0443-0273 110 µM 0.00181184710927774 0.499872802360475 no 1676 0.499277177977965 2389 6149169 SGTC_2015 5119600 184 µM 0.00150497253197642 0.499771139198063 no 1677 0.499399603052796 2399 2828786 SGTC_2618 avocadyne 43.43 µM 0.00148397004400562 0.49976418137438 no 1678 0.499407981823884 2402 3015189 SGTC_1055 3448-0672 86 µM 0.000729648318792821 0.499514285446314 no 1679 0.499708912461638 2399 748378 SGTC_480 am 92016 50 µM 0.000321756169338406 0.499379156722505 no 1680 0.499871637862286 2403 2129 K+ channel blocker. SGTC_2408 sulbentine 18.36 µM -9.48166401454668e-05 0.499241152296187 no 1681 0.499962173633417 2407 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_412 gemfibrozil 100 µM -0.000670664022677583 0.499050382706497 no 1682 0.499732443785467 2408 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_640 3381-0960 37.1 µM -0.0014139367727041 0.498804147934242 no 1683 0.499435921027507 2408 1745025 SGTC_3275 9138069 49.47 µM -0.00149657836287074 0.498776770079355 no 1684 0.49940295183799 2417 17617007 SGTC_575 k072-0246 11.9 µM -0.00172190408036888 0.498702123254024 no 1685 0.499313059999003 2410 6796779 SGTC_1727 st034309 9.9045 µM -0.00307158336508285 0.498254997022325 no 1686 0.498774617454728 2412 870305 SGTC_1245 0418-0076 17.2 µM -0.00359742610814991 0.498080794656083 no 1687 0.498564837720359 2418 6790114 SGTC_2572 astragaloside iv 100 µM -0.00373507408998239 0.498035194382255 no 1688 0.498509924489694 2430 45006101 An anti-inflammatory agent. SGTC_2335 9018011 154.17 µM -0.00391210776474858 0.497976546382244 no 1689 0.498439298788137 2417 6458208 SGTC_2121 5257820 149.641 µM -0.00426695185530119 0.49785899319516 no 1690 0.498297737661965 2415 791256 SGTC_2790 5423970 71.43 µM -0.00558149431043411 0.497423511652728 no 1691 0.49777331749309 2427 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2252 omeprazole 400 µM -0.00606539358422325 0.497263206277097 no 1692 0.497580272888543 2443 4594 A proton pump inhibitor. SGTC_2834 9001755 58.44 µM -0.00658529246071502 0.497090975503955 no 1693 0.497372867396698 2444 2989575 SGTC_1906 st060206 94.7 µM -0.00716890079263018 0.496897639872494 no 1694 0.497140046866832 2416 5133468 SGTC_943 3253-1379 105 µM -0.00789157008453719 0.496658237650091 no 1695 0.49685175171174 2424 668464 SGTC_1461 k072-0203 53.8 µM -0.00802533869290709 0.496613923592535 no 1696 0.496798387448104 2399 5418714 SGTC_3264 9137442 49.47 µM -0.00835096384760296 0.496506052631512 no 1697 0.496668486161649 2422 17015726 SGTC_834 0312-0008 75.7 µM -0.00900131522457021 0.496290609274363 no 1698 0.496409043269849 2421 6385573 YIL048W NEO1 SGTC_1397 3532-0190 20.1 µM -0.00946709230628292 0.496136310918587 no 1699 0.496223233022628 2419 5322280 SGTC_907 3448-6986 75.5 µM -0.00985425609939894 0.496008055290299 no 1700 0.496068784224494 2426 590582 SGTC_1793 st048256 72.231 µM -0.0109778665171727 0.495635839603648 no 1701 0.495620552861663 2423 672022 SGTC_2192 5915882 198.485 µM -0.0125592792932013 0.495111975355838 no 1702 0.494989704195834 2430 2876149 SGTC_2396 5342950 42.78 µM -0.0130548335862301 0.494947818024409 no 1703 0.494792022850713 2437 1886677 SGTC_1857 st056007 79.3 µM -0.014044245202693 0.494620068086578 no 1704 0.494397340971773 2440 619834 SGTC_1046 2001-0062 216 µM -0.0160508746699867 0.493955368573456 no 1705 0.493596902396854 2439 739778 SGTC_2395 5646831 180.19 µM -0.0163874067192057 0.493843893338006 no 1706 0.493462663192023 2439 6808628 SGTC_522 1273-0010 11.6 µM -0.0172849866312474 0.493546575049565 no 1707 0.493104631374089 2556 5705015 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0176342564937862 0.493430882335384 no 1708 0.492965314095606 2439 5106787 A p450 inhibitor. SGTC_3235 9132602 49.47 µM -0.0177794287553305 0.493382795402672 no 1709 0.49290740782104 2491 4912240 SGTC_1971 st069429 63.5 µM -0.0181470810771809 0.493261014494944 no 1710 0.492760759428244 2435 1246522 YGL099W LSG1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.018531571954868 0.493133656667379 no 1711 0.492607395554324 2449 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1140 3229-1848 2.98 µM -0.0187781632782414 0.493051976721932 no 1712 0.492509036965784 2430 2849525 SGTC_2844 9010103 25.97 µM -0.0191358217355761 0.492933507852044 no 1713 0.492366377521861 2485 2480525 SGTC_280 3448-3607 3.04 µM -0.0193573334352016 0.492860135816137 no 1714 0.492278023505496 2432 626179 SGTC_416 estradiol valerate 100 µM -0.0199953941457516 0.492648790264317 no 1715 0.492023523385722 2465 13791 A steroid. SGTC_2429 5902844 64.44 µM -0.0205052074152549 0.492479925733871 no 1716 0.491820179017073 2459 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_152 4469-0003 551.229 µM -0.0223248699448003 0.491877213394411 no 1717 0.491094405238502 2445 697280 SGTC_1904 st060225 78 µM -0.0233182630490655 0.491548187438957 no 1718 0.490698201933948 2438 66595 SGTC_3201 9113999 49.47 µM -0.025518504266927 0.490819456982802 no 1719 0.489820694511185 2498 16649224 SGTC_3126 9127922 49.47 µM -0.025818425326715 0.490720124006603 no 1720 0.489701082730904 2524 45595682 SGTC_3302 9125395 16.351 µM -0.0262137091793406 0.490589208032943 no 1721 0.489543440648285 2474 17599668 SGTC_479 n-linoleoylglycine 10 µM -0.0302549404694906 0.489250833719709 no 1722 0.487931866201127 2464 6433346 An anti-infammatory. SGTC_1123 mangostin 811.285 nM -0.030343857468338 0.489221387508206 no 1723 0.487896409730058 2512 5281650 An antioxidant. SGTC_911 3456-4043 236 µM -0.0310094894900184 0.489000955255201 no 1724 0.487630985897355 2496 914281 SGTC_3092 9117248 49.47 µM -0.0313463991278985 0.488889384750004 no 1725 0.487496643709252 2461 17141857 SGTC_824 1304-0008 100 µM -0.0322358765761581 0.488594830893852 no 1726 0.487141972833407 2465 768245 SGTC_1746 st038117 42 µM -0.0323018502907951 0.488572983691966 no 1727 0.487115666828766 2504 2898218 SGTC_1248 0469-0687 58.6 µM -0.0327631365350496 0.488420229669893 no 1728 0.486931737601909 2493 4017482 SGTC_2876 9059903 25.97 µM -0.0328793321903545 0.488381751976757 no 1729 0.486885407203284 2460 6916095 SGTC_2161 5662504 8.5105 µM -0.0337935445756553 0.48807901826558 no 1730 0.486520891844753 2496 2859334 SGTC_742 0kpi-0133 140 µM -0.0340174703912388 0.488004868163257 no 1731 0.486431609702818 2488 2728852 SGTC_3338 9144300 39.5675 µM -0.034265009984738 0.487922899150149 no 1732 0.486332913231416 2486 4901274 SGTC_2887 9044784 58.44 µM -0.0344542666317969 0.487860230002053 no 1733 0.486257455308555 2476 6465546 SGTC_511 blebbistatin 171 µM -0.0356079035043934 0.487478229139553 no 1734 0.485797503117295 2529 3476986 A myosin inhibitor. SGTC_2908 7930301 100 µM -0.0356724985903171 0.487456840268349 no 1735 0.485771749767874 2466 2223178 SGTC_1791 st048313 56.1 µM -0.0368674284492929 0.487061178957593 no 1736 0.48529535520738 2480 1204976 SGTC_2331 7980721 200 µM -0.0370018677437523 0.487016664642975 no 1737 0.485241758258811 2526 2981221 SGTC_1756 st041558 35.5 µM -0.0373667407533085 0.486895852032427 no 1738 0.485096295587514 2465 3955792 SGTC_1983 st071813 46.9 µM -0.0376632423728779 0.486797678665873 no 1739 0.484978091763495 2520 11838595 SGTC_213 1246-0773 967 nM -0.0384895104779613 0.486524100853809 no 1740 0.484648697357085 2516 6251622 SGTC_2531 methyl deoxycholate 70.07 µM -0.0393442642123236 0.486241098109824 no 1741 0.484307958090124 2493 16667744 Haematoxylin. SGTC_1323 1348-1351 11.2 µM -0.040645605567502 0.485810246806019 no 1742 0.483789213095743 2493 6989654 SGTC_1631 benzylvanillin 81.9 µM -0.0422343235785898 0.485284272635053 no 1743 0.483155950351298 2548 75506 SGTC_134 0269-0018 6.916 µM -0.0425080396523941 0.485193656479729 no 1744 0.483046851414531 2520 4378915 SGTC_955 1216-0110 33 µM -0.0426234606537687 0.485155445553406 no 1745 0.483000846792523 2480 3619719 SGTC_1448 4255-0083 152 µM -0.0440379975429812 0.484687164443627 no 1746 0.482437057787311 2502 5399660 SGTC_1270 0831-1170 17.3 µM -0.0457091083100546 0.484133972053892 no 1747 0.481771052008705 2486 6764716 SGTC_1493 4348-0038 111 µM -0.0474448070441964 0.483559431277228 no 1748 0.481079359175122 2502 800424 SGTC_1520 flindersine 88 µM -0.0475317023903654 0.483530668578635 no 1749 0.481044732014047 2596 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3189 9110682 49.47 µM -0.0476183345198237 0.483501993091117 no 1750 0.48101020988528 2521 17122418 SGTC_2301 7769476 200 µM -0.0482180370109895 0.483303492165468 no 1751 0.480771237725286 2518 977820 SGTC_151 3013-0144 2.285 µM -0.0514780457503324 0.482224506193294 no 1752 0.479472297802739 2674 906558 YHR107C CDC12 SGTC_2120 5538279 151.968 µM -0.0525243150521846 0.481878242957935 no 1753 0.479055460731013 2518 2058197 SGTC_400 oxethazaine 37.5 µM -0.0527300039618263 0.481810171732381 no 1754 0.478973516284504 2550 4621 A local anesthetic. SGTC_941 3237-0776 460 µM -0.052842729716639 0.481772866201179 no 1755 0.478928607824925 2538 760008 SGTC_338 4055-0136 114 µM -0.0543722784916821 0.481266692291531 no 1756 0.478319282366188 2493 2900563 SGTC_2837 9008476 45.46 µM -0.0547996158941144 0.481125278794209 no 1757 0.478149053208244 2586 2992805 SGTC_1718 roemerine 11.9335 µM -0.0548752606862049 0.481100246842815 no 1758 0.478118920642963 2506 235224 An aporphine alkaloid with mutagenic activity. SGTC_1420 4'-methoxyflavone 42 µM -0.0554227906576144 0.480919063515804 no 1759 0.477900819710341 2495 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1260 0700-1617 7.75 µM -0.0556714664736159 0.480836775417254 no 1760 0.47780176534672 2535 2853078 SGTC_701 4424-0219 185 µM -0.0561244477128968 0.480686883710787 no 1761 0.47762133408609 2512 2911779 SGTC_2983 9022671 12.99 µM -0.0562081430033606 0.480659189197801 no 1762 0.47758799712083 2665 6405161 SGTC_1555 citronellol 128 µM -0.056780605294527 0.480469765704504 no 1763 0.47735998187091 2508 8842 A terpine precursor. SGTC_3172 9105863 49.47 µM -0.056794389485137 0.480465204673061 no 1764 0.477354491634128 2500 2348785 SGTC_1677 st019204 53.9 µM -0.0589471194032513 0.479752922665177 no 1765 0.476497113709213 2618 3945625 SGTC_799 1310-0557 151 µM -0.0608744177561624 0.479115284844435 no 1766 0.475729611662196 2627 5354492 SGTC_1501 4491-0275 38.4 µM -0.0621135231799117 0.478705360622376 no 1767 0.475236213926627 2507 5104718 SGTC_1956 st077085 54 µM -0.0654540860875311 0.477600339965026 no 1768 0.473906230947038 2565 24208685 SGTC_1470 k295-0292 231 µM -0.0667615527397547 0.477167891111499 no 1769 0.473385765779527 2627 5045612 SGTC_1228 0124-0032 52.5 µM -0.0685136030735575 0.476588437000363 no 1770 0.472688395917235 2567 X1228 SGTC_1151 3909-8316 15.3 µM -0.0698920277647556 0.476132586509989 no 1771 0.472139799267709 2627 800431 SGTC_2153 5569715 200 µM -0.0712235034900924 0.475692291878743 no 1772 0.471609937917908 2531 2054701 SGTC_2450 5739737 12.93 µM -0.072101528510896 0.475401961294584 no 1773 0.471260554908899 2584 2262825 SGTC_2611 pyromycin 23.93 µM -0.072976241792063 0.475112738767098 no 1774 0.470912511697014 2571 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2874 9043904 71.43 µM -0.0732823732439123 0.475011519989273 no 1775 0.470790709047745 2610 4463428 SGTC_563 tetrahydrosecaminediol 614 µM -0.078649675619793 0.473237152192249 no 1776 0.46865563722574 2590 334274 A psychoactive constituent of the cannabis plant. SGTC_832 4083-0019 164 µM -0.0792885024013668 0.473025998147119 no 1777 0.468401575632252 2647 1990758 SGTC_1433 4060-0023 7.6 µM -0.0809044087663555 0.472491919934505 no 1778 0.46775898688674 2632 3840627 SGTC_295 k015-0027 31 µM -0.0815136651450677 0.47229056550975 no 1779 0.467516728914392 2613 3887424 SGTC_2315 7733312 200 µM -0.0827507021023525 0.47188175639804 no 1780 0.467024884318711 2587 726316 SGTC_2708 st078559 56 µM -0.0834084065967423 0.471664413899353 no 1781 0.466763402154235 2556 17250902 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0836564482576821 0.471582449193417 no 1782 0.466664792482171 2590 1273210 SGTC_2909 7941780 10.49 µM -0.0845148256571139 0.471298809980621 no 1783 0.466323557921713 2555 1243215 SGTC_2179 6298986 200 µM -0.0859618639648464 0.470820688755106 no 1784 0.465748366557561 2611 738374 SGTC_579 4491-1009 110 µM -0.0881146106329098 0.470109469878701 no 1785 0.464892791971589 2542 1271041 SGTC_697 0508-1955 564 µM -0.0888929727813517 0.469852339955492 no 1786 0.464583484175959 2559 6243113 SGTC_3343 9148379 18.9835 µM -0.0903518240772457 0.469370446146656 no 1787 0.464003819429501 2627 1955036 SGTC_1993 st073995 70.8 µM -0.0905702535872596 0.469298297449609 no 1788 0.463917034479556 2610 3098394 SGTC_1292 0kpi-0043 232 µM -0.0931322209372319 0.468452138748193 no 1789 0.462899260031122 2600 3333905 SGTC_2458 5808907 16.39 µM -0.0938006894451752 0.468231382310001 no 1790 0.462633742001618 2570 2731747 SGTC_3147 9097027 49.47 µM -0.0945032150940129 0.467999389299252 no 1791 0.462354714300878 2605 25236841 SGTC_1690 st023502 41.2 µM -0.0957480932168561 0.467588323541922 no 1792 0.461860321735395 2587 24207482 SGTC_529 4076-0302 30.3 µM -0.0958749347228346 0.467546441696068 no 1793 0.461809951024875 2580 5816522 SGTC_2747 doxorubicin 7.63 µM -0.0964468072263012 0.467357619361197 no 1794 0.461582859287048 2563 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3176 9106582 49.47 µM -0.0966865767413738 0.467278453828609 no 1795 0.461487650045758 2558 17018027 SGTC_2298 7976326 193.81 µM -0.097605417851218 0.466975088882716 no 1796 0.461122811114361 2625 2235818 SGTC_392 N-ethylmaleimide 8.33 µM -0.0976195677751786 0.46697041728773 no 1797 0.461117192940824 2611 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_803 4488-1585 147 µM -0.0988086098624397 0.466577871563719 no 1798 0.460645116134274 2605 747204 SGTC_2847 9005661 71.43 µM -0.100152343802354 0.466134295621127 no 1799 0.460111689923402 2570 2991449 SGTC_42 0133-0086 60.653 µM -0.100491769474358 0.466022255473451 no 1800 0.459976958385037 2589 162923 Model of phenazepam hydroxylation. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.101139673765691 0.465808397894622 no 1801 0.459719792194548 2715 61125 An anti-inflammatory. SGTC_1689 st020265 53.493 µM -0.101488384850164 0.465693300859763 no 1802 0.459581388749245 2606 5758320 YPR016C TIF6 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.103822667002024 0.464922912323823 no 1803 0.458655039005028 2699 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_97 0535-0701 19.132 µM -0.104642185305925 0.464652475833809 no 1804 0.458329869703925 2630 2832013 YGL099W LSG1 SGTC_1042 0350-0096 82 µM -0.105368305898163 0.464412873708539 no 1805 0.458041782132804 2562 3122515 SGTC_1939 st074455 53.6 µM -0.106132959755289 0.464160570495073 no 1806 0.457738430359041 2672 1644229 SGTC_1505 k297-0037 20.6 µM -0.106446481116178 0.464057125955984 no 1807 0.457614057969709 2615 4089396 SGTC_650 1328-0195 38 µM -0.107839666500591 0.463597482071493 no 1808 0.457061438516185 2583 2780821 SGTC_2025 5147754 141 µM -0.108490376254111 0.463382814574861 no 1809 0.456803357046488 2672 315777 YLR208W SEC13 SGTC_755 1995-0008 37.3 µM -0.108570982343756 0.463356223571293 no 1810 0.456771388700897 2585 689533 SGTC_83 0170-0301 39.027 µM -0.108947402612754 0.463232049108819 no 1811 0.456622104267399 2589 3089716 SGTC_749 1000-0129 128 µM -0.111052097351309 0.462537813481352 no 1812 0.45578751723524 2712 708470 SGTC_883 0850-0245 24.6 µM -0.11414548003191 0.461517665844697 no 1813 0.454561234974116 2794 6823229 YPR165W RHO1 SGTC_1212 0520-0165 585 µM -0.1144241997268 0.461425760924291 no 1814 0.454450765685608 2946 5403258 SGTC_645 0845-0943 5.41 µM -0.115879683949751 0.460945863717755 no 1815 0.45387394853571 2650 1885106 SGTC_2456 5770359 74.46 µM -0.117280443877682 0.460484063709456 no 1816 0.453318910799557 2745 3118787 SGTC_2521 angolensin 13.4 µM -0.119162686209703 0.45986361347838 no 1817 0.452573234025994 2745 821428 A flavenoid. SGTC_360 0957-0399 1.01 µM -0.120359438022812 0.459469174649302 no 1818 0.452099210764547 2731 6752301 YPR165W RHO1 SGTC_2207 7258803 200 µM -0.120600001908978 0.45938989171975 no 1819 0.452003933665672 2655 3666799 SGTC_3011 9081274 71.4286 µM -0.121547214084759 0.459077733591301 no 1820 0.451628810227888 2652 6625322 SGTC_383 2324-0395 7.37 µM -0.121739302269098 0.459014433117588 no 1821 0.451552743003239 2740 3146421 SGTC_2051 5263410 176 µM -0.122061521397331 0.458908251807612 no 1822 0.451425147715041 2600 227584 SGTC_1728 st035614 33.7865 µM -0.122541558672272 0.458750069907167 no 1823 0.451235067459415 2757 15945546 SGTC_2713 st079149 53.4 µM -0.122590770230362 0.458733854081426 no 1824 0.451215581800577 2680 3103253 SGTC_936 3005-4620 401 µM -0.123040695005944 0.458585601410875 no 1825 0.451037436411438 2700 777207 SGTC_2703 st077852 53.4 µM -0.123971359421514 0.458278960707729 no 1826 0.450668975983759 2752 6281836 SGTC_435 c-PAF 6.7 µM -0.125091530442681 0.457909913212398 no 1827 0.450225544178487 2634 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_898 1000-0849 28.3 µM -0.125260406299552 0.45785427912272 no 1828 0.450158698221399 2599 6751807 SGTC_733 4069-0007 56.1 µM -0.125473058410417 0.457784224655226 no 1829 0.450074526366183 2632 5717425 YNL287W SEC21 SGTC_2919 7978188 46.38 µM -0.126970290657709 0.457291025285458 no 1830 0.449481956411203 2680 2980291 SGTC_1082 camptothecin 424.86 nM -0.127560922704008 0.457096484771171 no 1831 0.449248228792764 2573 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_589 1227-0070 34.1 µM -0.128326295498753 0.456844404002228 no 1832 0.448945378170611 2737 2841384 SGTC_1428 4049-0204 61.7 µM -0.129964172103648 0.456305016600194 no 1833 0.448297386371898 2738 X1428 SGTC_1974 st069448 26.9 µM -0.13201474560911 0.455629832989301 no 1834 0.447486314260179 2721 6323587 YNR016C ACC1 SGTC_1825 st052143 62.6 µM -0.132606211500112 0.455435107255085 no 1835 0.447252409871234 2758 674173 SGTC_906 1165-0455 526 µM -0.134768790755141 0.454723222206899 no 1836 0.446397341023557 2632 3252859 SGTC_3088 9117578 49.47 µM -0.135496957122364 0.454483554580851 no 1837 0.446109484968376 2657 678341 SGTC_460 trequinsin 123 µM -0.135664433038756 0.454428434140342 no 1838 0.446043283015549 2643 5537 A vasodilator. SGTC_1302 1159-0335 255 µM -0.136277357439304 0.454226713145879 no 1839 0.44580101151253 2637 649284 SGTC_2232 chlorophetanol 41.5365 µM -0.137113886755834 0.453951420072362 no 1840 0.445470388048117 2665 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2000 st075254 36.4 µM -0.137537076170127 0.453812161267928 no 1841 0.445303144322671 2657 17234175 SGTC_1040 k898-0338 155 µM -0.139855544413141 0.453049324892122 no 1842 0.444387063202021 2667 20969351 SGTC_1467 k284-1082 293 µM -0.141246991987333 0.452591585436711 no 1843 0.443837411964921 2719 3334705 SGTC_2566 crystal violet carbinol 226 nM -0.141774443106557 0.452418088190949 no 1844 0.443629085787954 2835 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_16 erodoxin 22.806 µM -0.141915467039111 0.452371701991665 no 1845 0.443573388520873 2659 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1701 st028638 40.4 µM -0.142322529112453 0.452237813029827 no 1846 0.443412626001132 2673 3490878 SGTC_2477 5967686 25.23 µM -0.14278644517273 0.45208523054235 no 1847 0.443229421284376 2656 776118 SGTC_3008 9078912 71.4286 µM -0.143127114206297 0.451973188638675 no 1848 0.443094895676836 2683 16648731 SGTC_1241 0364-0022 50.8 µM -0.143751981301336 0.451767687396205 no 1849 0.442848161147625 2742 4563895 SGTC_3228 9131799 49.47 µM -0.143955892380559 0.451700629561732 no 1850 0.442767649770903 2708 17015818 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.144405070472527 0.451552918518121 no 1851 0.442590306559343 2675 6708514 SGTC_145 3737-0113 38.366 µM -0.144598441656308 0.451489330972928 no 1852 0.442513963840591 2778 6849351 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.144745655921402 0.451440922351727 no 1853 0.442455845250707 2721 6857784 SGTC_2634 4'-methoxyflavone 100 µM -0.145081404817312 0.451330520392718 no 1854 0.442323299875191 2721 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2263 7948595 193.29 µM -0.146410339666154 0.450893573070115 no 1855 0.441798732697064 2658 2971371 SGTC_1682 st012968 530 nM -0.147430916513067 0.45055805272657 no 1856 0.441395952147556 2684 24207270 SGTC_770 0389-1121 67.2 µM -0.14744027826885 0.450554975160185 no 1857 0.441392257719715 2849 6753108 SGTC_2797 7859098 81.82 µM -0.148591687167302 0.450176485840747 no 1858 0.440937916433318 2708 972681 SGTC_1017 4239-0030 168 µM -0.151466649939324 0.449231631166124 no 1859 0.43980380838695 2705 1149593 SGTC_109 0132-0036 33.701 µM -0.1520732425068 0.449032311496316 no 1860 0.439564584055755 2645 67274 A color developer. SGTC_2173 5763948 167 µM -0.152565944197024 0.448870424584412 no 1861 0.439370291561156 2669 2867177 SGTC_997 3996-0078 137 µM -0.153453263999852 0.448578899551714 no 1862 0.439020421816549 2744 735687 SGTC_2278 7948257 134.34 µM -0.154497221632055 0.448235947405453 no 1863 0.438608850867799 2715 1247028 SGTC_2069 5228469 200 µM -0.155811554040788 0.447804229060704 no 1864 0.43809078152679 2803 2835210 SGTC_2393 9031399 185.94 µM -0.155859084122733 0.44778861802513 no 1865 0.438072048615143 2808 1526623 YDL150W RPC53 SGTC_1113 artemisinin 1.17947 µM -0.156419317051444 0.447604618211777 no 1866 0.437851255889052 2705 2240 An anti-malaria and mitochondrial poison. SGTC_3229 9132204 49.47 µM -0.157580103372559 0.447223411880575 no 1867 0.437393841437989 2670 17682924 SGTC_199 4063-0024 41.6 µM -0.15770534614178 0.447182284619985 no 1868 0.437344493802119 2805 306215 SGTC_2759 disulfiram 3.38 µM -0.158133748020478 0.447041610170801 no 1869 0.437175704046374 2690 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_904 1141-0088 396 µM -0.158790557277728 0.446825946468761 no 1870 0.436916944309352 2735 1378119 SGTC_853 0419-0306 21 µM -0.160495801212752 0.446266102194181 no 1871 0.436245264450653 2677 762713 SGTC_417 st075190 100 µM -0.160653563886675 0.446214312929644 no 1872 0.436183132448333 2818 222757 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.163188258713601 0.445382366830817 no 1873 0.435185105238518 2747 75037 A free radical scavenger. SGTC_3005 9076496 71.4286 µM -0.163571793338602 0.445256502656406 no 1874 0.435034125620462 2750 21368410 SGTC_3222 9128301 49.47 µM -0.165805739329734 0.444523500907234 no 1875 0.434154914656763 2728 4911358 SGTC_2074 5212007 75.395 µM -0.167141089445418 0.444085436611165 no 1876 0.433629518012038 2718 758611 SGTC_556 4058-0063 51.5 µM -0.167464142633329 0.443979468602673 no 1877 0.433502429554757 2705 6615692 SGTC_201 4262-0159 12.803 µM -0.168359252975348 0.443685875171584 no 1878 0.433150330950159 2808 1341029 SGTC_356 1634-0012 32.5 µM -0.170717455316056 0.442912540462586 no 1879 0.432222968480585 2721 735457 SGTC_1441 4106-0040 13 µM -0.171166431636179 0.442765330414356 no 1880 0.432046450802263 2699 2904180 SGTC_63 0099-0242 26.702 µM -0.173928806600451 0.441859779413967 no 1881 0.430960706633302 2811 3898502 YLR359W ADE13 SGTC_289 k017-0060 526 µM -0.174282773988451 0.44174376506111 no 1882 0.43082161821508 2725 5512909 SGTC_1328 1441-0025 69.2 µM -0.174334176399233 0.441726918112447 no 1883 0.430801420796197 2690 4562601 SGTC_899 1083-0020 478 µM -0.175939071490942 0.441200972903243 no 1884 0.430170904744191 2894 767123 SGTC_3314 9135860 59.4275 µM -0.176557769316675 0.44099824513419 no 1885 0.429927884029153 2743 25252478 SGTC_585 0kpi-0023 191 µM -0.178276847466835 0.440435038749376 no 1886 0.429252780291958 2847 64601 SGTC_599 1935-0052 86.5 µM -0.18098439555255 0.439548233439438 no 1887 0.428189912147149 2721 9557311 SGTC_2451 5856223 45.7 µM -0.181415343908343 0.439407112453581 no 1888 0.428020788003731 2765 2179896 SGTC_2819 7996655 46.38 µM -0.181464003962953 0.439391178417789 no 1889 0.428001692369232 2814 6456960 SGTC_545 4218-0007 221 µM -0.182663106592982 0.438998555934543 no 1890 0.42753118266343 2837 2840508 SGTC_988 1497-1057 103 µM -0.183272539754873 0.438799032053726 no 1891 0.427292089777131 2731 3533044 SGTC_1697 st025554 27.742 µM -0.184037004575489 0.438548773955985 no 1892 0.426992212620257 2712 1269519 SGTC_1530 rhein 70.4 µM -0.184194647025673 0.438497170578912 no 1893 0.426930379345735 2712 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2744 captopril 92.04 µM -0.184832081341958 0.438288520680303 no 1894 0.426680372050568 2796 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_678 1218-2179 85.9 µM -0.186015427059394 0.437901224387534 no 1895 0.426216331711854 2723 6820081 YOR116C RPO31 SGTC_2242 6630449 61.2675 µM -0.190147943810703 0.436549165132501 no 1896 0.424596600811658 2935 691249 YDR170C SEC7 SGTC_1875 nocodazole 6 µM -0.190800348926459 0.436335781318843 no 1897 0.424341007651642 2750 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1507 4075-3230 155 µM -0.191490794722278 0.436109975622127 no 1898 0.424070545923487 2701 659771 SGTC_1415 3966-0071 78.1 µM -0.194780300389336 0.435034451881539 no 1899 0.422782472459653 2761 2893185 SGTC_2546 rhodinyl acetate 100 µM -0.194942182574038 0.434981535863651 no 1900 0.422719105357723 2759 6708682 SGTC_1215 3852-0577 11.2 µM -0.195552827025534 0.434781939009891 no 1901 0.422480092933415 2915 2884876 SGTC_322 k048-0136 19.3 µM -0.19602310604764 0.434628233695822 no 1902 0.422296040408821 2838 6823282 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.197591121542025 0.434115817302103 no 1903 0.421682490917845 2940 688798 SGTC_223 busulfan 5 mM -0.197856277924716 0.434029176985967 no 1904 0.42157875650517 2863 2478 A DNA alkylator. SGTC_854 0422-0053 192 µM -0.198023766211877 0.433974451525348 no 1905 0.421513234584005 2767 3596728 SGTC_2158 5657123 3.6195 µM -0.19807801783481 0.433956725511987 no 1906 0.421492011651975 2727 2858827 SGTC_329 k048-0121 21.3 µM -0.198538914617906 0.433806138833057 no 1907 0.421311720608285 2841 6832902 SGTC_1849 st056239 19.2 µM -0.199560328125988 0.433472451378662 no 1908 0.420912228588957 2765 5393181 SGTC_2736 butenafine 14.65 µM -0.199801819897652 0.433393564910158 no 1909 0.420817788977359 2794 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_759 3486-0358 89.3 µM -0.201280648632173 0.43291054401662 no 1910 0.420239566534506 2865 875103 SGTC_1984 st072354 53.1 µM -0.2017926219564 0.432743344580742 no 1911 0.420039424863423 2742 5762938 SGTC_1513 0337-0559 19 µM -0.202358627194377 0.432558513503443 no 1912 0.419818184991216 2778 775073 SGTC_107 0358-0022 2.6945 µM -0.203527928410027 0.432176720697125 no 1913 0.419361209379713 2833 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_677 0929-0063 136 µM -0.203663661686618 0.432132406025237 no 1914 0.419308170373948 2743 1539583 SGTC_1694 st024011 44.9 µM -0.204888506494138 0.431732553119404 no 1915 0.418829617609739 2781 2787533 SGTC_725 1497-0963 19 µM -0.205682359713433 0.431473435558599 no 1916 0.418519519426044 2893 3549977 SGTC_1184 1269-1718 139 µM -0.208463737606873 0.430565813601136 no 1917 0.417433446918939 2920 5403821 SGTC_1958 st076513 41.9 µM -0.208534481901093 0.430542733015277 no 1918 0.417405830860986 2760 732122 YGL099W LSG1 SGTC_1741 st038134 10.228 µM -0.209936687037744 0.430085307497851 no 1919 0.416858544051058 2976 1272587 SGTC_1494 4358-1428 177 µM -0.211027669005863 0.429729473656031 no 1920 0.416432840376919 2909 1564571 SGTC_2597 laccaic acid a 100 µM -0.211324738058045 0.429632591716594 no 1921 0.416316940303997 2906 5491415 A textile dye. SGTC_1657 st012939 43.4 µM -0.211366599290579 0.4296189400211 no 1922 0.41630060892855 2937 24207257 SGTC_229 benomyl 22.8748 µM -0.212754837716786 0.429166258450184 no 1923 0.415759095741446 2863 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2175 5807670 165.306 µM -0.213805961209954 0.428823566406755 no 1924 0.415349188037075 2887 241186 SGTC_5 0352-0601 109.883 µM -0.21388696059717 0.428797160842741 no 1925 0.415317604440139 2838 762456 SGTC_2449 5812982 45.77 µM -0.214207547392345 0.428692653610437 no 1926 0.415192605357209 2808 776185 SGTC_606 k015-0008 38.6 µM -0.215128557012857 0.428392443984773 no 1927 0.414833544917991 2920 1970475 SGTC_2251 lansoprazole 556 µM -0.215160908619272 0.428381899501212 no 1928 0.414820933765815 2786 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1028 k015-0029 4.8 µM -0.216593940373768 0.427914877347756 no 1929 0.414262404263648 2776 4588309 SGTC_1814 st052110 31.539 µM -0.22016671953731 0.42675095686263 no 1930 0.412870657328172 2910 674163 SGTC_1668 st014914 51.6 µM -0.220782160416904 0.426550525980352 no 1931 0.41263102738 2808 2839556 SGTC_3111 9122088 49.47 µM -0.221251308436519 0.426397751090194 no 1932 0.412448380333081 2848 16876704 SGTC_646 4092-0839 27.3 µM -0.221608951589035 0.426281294425448 no 1933 0.412309156698925 2939 877796 SGTC_94 0334-0113 514.748 µM -0.223096202742725 0.425797081010042 no 1934 0.411730316828689 2820 6795178 SGTC_2967 9089538 49.85 µM -0.223289100018313 0.425734286449679 no 1935 0.411655255028116 3039 728216 SGTC_2409 alverine citrate 63.97 µM -0.223764857615768 0.425579419381509 no 1936 0.411470138079842 3060 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_469 w7 172 µM -0.223804877544533 0.425566392747392 no 1937 0.41145456725155 2813 45115570 A P450 inhibitor. SGTC_1680 diphenhydramine 100 µM -0.224617564841528 0.425301877637174 no 1938 0.411138399632867 2859 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2551 apiole 73.87 µM -0.225010049386797 0.425174143003055 no 1939 0.410985728217788 2785 10659 A possible DNA adduct former. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.225328450992318 0.425070524533411 no 1940 0.410861884012884 2771 1241132 A phosphatase inhibitor. SGTC_2920 7982904 15.77 µM -0.226646927090507 0.424641503744419 no 1941 0.410349149569018 2918 6456808 SGTC_711 k292-0785 179 µM -0.22669926783591 0.42462447435443 no 1942 0.410328798239167 2779 4146315 SGTC_1272 0839-0021 27 µM -0.226739034301249 0.424611536179419 no 1943 0.410313336250659 2888 5027250 SGTC_2417 cerulenin 830 nM -0.22714258753391 0.424480243153883 no 1944 0.410156434659514 2802 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.227177732643065 0.424468809351946 no 1945 0.410142770913293 2890 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2330 7979373 200 µM -0.227294753726752 0.424430739195897 no 1946 0.410097276140661 2815 1863007 SGTC_423 5-fluorouracil 457 µM -0.228600466201769 0.42400600314939 no 1947 0.409589731092589 2759 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1644 st010134 20.9 µM -0.231156889556248 0.423174678552152 no 1948 0.408596460090752 2860 3818134 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.231211138116433 0.423157041127554 no 1949 0.408575388728186 2869 756377 SGTC_487 nimodipine 119 µM -0.232887704904706 0.422612027726302 no 1950 0.407924303018528 2899 4497 L-type voltage-gated calcium channels inhibitor SGTC_1412 3909-8563 178 µM -0.233034975444834 0.422564160513745 no 1951 0.407867123413619 2913 23767530 SGTC_485 niflumic acid 177 µM -0.236048460119687 0.42158494234128 no 1952 0.406697533356396 2941 4488 A COX2 inhibitor. SGTC_2425 5628681 7.85 µM -0.236550367180737 0.421421896844509 no 1953 0.406502814313169 2911 5714958 SGTC_774 k060-0086 136 µM -0.238767691776917 0.420701756181467 no 1954 0.405642861965854 2830 5911235 SGTC_2296 7971656 126.45 µM -0.239106174929923 0.420591847211929 no 1955 0.40551162686801 2904 666570 SGTC_2757 clomiphene 4.22 µM -0.240538958321063 0.420126676331315 no 1956 0.404956232622833 3048 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1127 asiatic acid 681.4 nM -0.241289191289201 0.419883148358489 no 1957 0.404665493775769 2803 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1783 st039459 87.517 µM -0.24170801820267 0.419747209165993 no 1958 0.404503208067672 3048 729761 SGTC_2630 antimycin a 100 µM -0.244433700505711 0.418862765581796 no 1959 0.403447471979647 2781 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2349 9023730 187.07 µM -0.244498819226297 0.41884164051641 no 1960 0.403422258174571 2979 4126287 SGTC_333 3486-0131 40.1 µM -0.246533066455253 0.418181831599389 no 1961 0.402634805413427 3002 6744690 SGTC_605 1315-0399 119 µM -0.247022183646144 0.418023220496521 no 1962 0.402445527954678 2972 24020461 SGTC_2886 9058944 51.95 µM -0.248238552018141 0.4176288339695 no 1963 0.401974919725108 2862 4949929 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.24873454369289 0.417468040952126 no 1964 0.401783063202086 3052 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1926 methyl fluorone black 53.6 µM -0.248782440802023 0.417452514162244 no 1965 0.401764537182215 2844 72721 Reacts with homocysteine. SGTC_2292 7671323 168.05 µM -0.248999558673951 0.417382132748601 no 1966 0.401680561396268 2994 937504 SGTC_767 0929-0023 86 µM -0.251488729024571 0.416575427406317 no 1967 0.400718137590253 2872 1204563 SGTC_3161 9100388 49.47 µM -0.253087020950155 0.416057628261331 no 1968 0.400100484119853 2858 25236368 SGTC_1705 st027868 56.3335 µM -0.25331199017632 0.415984756584143 no 1969 0.40001356569006 2935 292948 SGTC_2287 7945887 168.79 µM -0.254095601412554 0.415730953035827 no 1970 0.399710850722978 2956 1245853 SGTC_3023 9089636 49.47 µM -0.255317920285321 0.41533512684532 no 1971 0.399238780056918 2915 17249241 SGTC_1104 tacrolimus 29.8 µM -0.255349279649681 0.415324972802467 no 1972 0.399226670720387 2873 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1715 st032160 10.2275 µM -0.255976746798175 0.415121813222283 no 1973 0.398984396317517 2972 5289825 SGTC_439 amiodarone 34.4 µM -0.256285145427179 0.415021969080652 no 1974 0.398865333274215 2920 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2060 5238662 140 µM -0.256563599802512 0.414931824114099 no 1975 0.39875783885226 2964 790130 SGTC_1311 1190-0148 100 µM -0.256838007775918 0.41484299348445 no 1976 0.398651914014426 2990 1961333 SGTC_1332 1480-0653 17.5 µM -0.261253566777251 0.413414202061748 no 1977 0.396948485847775 2993 5749438 SGTC_2991 9074669 71.4286 µM -0.261525861741874 0.41332612987512 no 1978 0.396843504249524 3069 17333109 SGTC_2464 5717415 7.67 µM -0.262197202671512 0.413109007284724 no 1979 0.396584704959813 2873 5285744 SGTC_875 0709-0210 25.7 µM -0.264568637679782 0.412342259741267 no 1980 0.395670891455672 2940 6251364 SGTC_2297 7971671 152.32 µM -0.265477279427362 0.412048560337166 no 1981 0.395320905246987 3039 909016 SGTC_3328 9140624 29.0385 µM -0.266403406495595 0.411749259856377 no 1982 0.394964270996375 3048 4904392 SGTC_1360 1598-0022 39.8 µM -0.266755894932328 0.411635358126107 no 1983 0.394828557377087 2994 761525 SGTC_3286 9117135 37.221 µM -0.2672738933772 0.411467987655033 no 1984 0.39462914294756 2916 3438150 SGTC_3344 9148862 3.898 µM -0.268914015823265 0.410938154106344 no 1985 0.393997925532981 3047 4905352 SGTC_1004 4084-0029 199 µM -0.268915741040494 0.410937596868699 no 1986 0.393997261712262 3038 716894 YLR208W SEC13 SGTC_1675 st018485 24.5 µM -0.270220397030537 0.410516250208346 no 1987 0.393495350816754 2956 3323024 SGTC_393 acivicin 6.25 µM -0.271789542731527 0.41000962178677 no 1988 0.392891923175024 2882 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1973 st070275 50.2 µM -0.272116736113973 0.409904000098425 no 1989 0.392766130692217 2868 17118334 SGTC_215 1287-0124 461.5 µM -0.273759928163234 0.409373658301158 no 1990 0.392134560115055 2935 5560863 SGTC_2384 9036245 200 µM -0.274031694840528 0.409285961301431 no 1991 0.392030132317483 2936 6462766 SGTC_2861 9024595 19.48 µM -0.274370305580651 0.409176700593192 no 1992 0.391900030213619 2933 16482810 SGTC_71 0417-1750 47.813 µM -0.275457125713814 0.408826060257689 no 1993 0.391482530420681 3112 6811472 SGTC_3056 9094900 49.47 µM -0.275934464366837 0.408672079725252 no 1994 0.391299201196507 2935 25236784 SGTC_1096 rimcazole 32.2 µM -0.275964900571537 0.408662262052006 no 1995 0.391287512524164 2868 18528119 A dopamine reuptake inhibitor. SGTC_3306 9127676 59.7925 µM -0.276036908441631 0.40863903501695 no 1996 0.391259859125524 2978 41905287 SGTC_272 doxorubicin 8.13 µM -0.281696513485262 0.40681446907593 no 1997 0.389088114055263 2892 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1525 8-methoxypsoralen 92.5 µM -0.282604465450728 0.406521946991111 no 1998 0.388740028443073 3156 4114 Related to psoralen; DNA damaging agent. SGTC_1179 1021-1431 9.29 µM -0.283263821118925 0.406309549828678 no 1999 0.388487304266391 2975 2840958 SGTC_118 0083-0097 135.343 µM -0.28627084864347 0.40534125140005 no 2000 0.387335341822981 2943 5207356 SGTC_1664 st014217 9.02 µM -0.288620528208335 0.404585029495409 no 2001 0.38643589225389 2951 3982782 SGTC_3000 9075062 71.4286 µM -0.289382906674908 0.404339741690704 no 2002 0.386144187096862 2945 17057871 SGTC_203 k066-0004 30.888 µM -0.289445007098701 0.404319763142315 no 2003 0.386120428746551 2968 6795412 SGTC_2826 7992541 19.48 µM -0.290413671295772 0.404008163066996 no 2004 0.385749892998481 2869 2985066 SGTC_2198 6589944 200 µM -0.291765415325516 0.403573435628282 no 2005 0.385232994903066 2949 5290268 SGTC_1742 st038235 28.8875 µM -0.292011916222191 0.403494172568896 no 2006 0.385138756516528 3039 564103 YBR002C RER2 SGTC_735 3076-0345 636 µM -0.293171695933266 0.403121295377985 no 2007 0.384695458709472 3082 2888990 SGTC_2735 sertaconazole 140 nM -0.294240665970906 0.402777692115122 no 2008 0.384287004160388 2925 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2245 6637752 200 µM -0.294546864553233 0.402679283315995 no 2009 0.384170029015891 3051 681890 SGTC_2317 5986382 200 µM -0.295141086636713 0.402488324584141 no 2010 0.383943052150936 2997 877883 SGTC_1342 1486-1464 234 µM -0.29665678708003 0.402001345761618 no 2011 0.383364275739912 2920 3253938 SGTC_808 0711-0032 135 µM -0.297851639732484 0.401617559173163 no 2012 0.382908199708007 3035 4252555 SGTC_2667 digitoxin 100 µM -0.298637101341207 0.401365320617725 no 2013 0.3826084768705 3004 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_867 0518-0118 155 µM -0.298651899102444 0.401360568945176 no 2014 0.382602830894384 3023 6848158 SGTC_1326 1431-2094 10.8 µM -0.299164799389603 0.401195881820975 no 2015 0.382407153019747 2875 616278 SGTC_1888 azatryptophan 97.5 µM -0.299820165850121 0.400985475787982 no 2016 0.382157166214409 3039 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2813 7971799 71.43 µM -0.301227950611707 0.40053360230572 no 2017 0.381620338778895 3040 2234054 SGTC_2823 7987624 58.44 µM -0.301897828474287 0.400318630304735 no 2018 0.381364975600034 3173 2239440 SGTC_673 1082-0474 110 µM -0.301959257003299 0.400298918648781 no 2019 0.381341561101796 2974 3098046 SGTC_1794 st048918 76.9 µM -0.302262712544546 0.400201547242059 no 2020 0.381225900384706 3016 672303 SGTC_2663 amphotericin b 100 µM -0.302978656615332 0.399971843022093 no 2021 0.380953063572626 2964 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2707 st078556 66.6 µM -0.30302120387851 0.39995819320377 no 2022 0.38093685123522 3013 17250899 SGTC_2832 7992762 51.95 µM -0.303199338374211 0.399901046237181 no 2023 0.38086897659985 2896 2985177 SGTC_3191 9110352 49.47 µM -0.304498444814499 0.39948434743301 no 2024 0.380374088695039 2951 17122424 SGTC_2073 5212005 126 µM -0.304528561680913 0.39947468856259 no 2025 0.380362618148371 2888 691789 SGTC_1661 st013063 9.66 µM -0.305190415688489 0.399262438925196 no 2026 0.380110565800503 2951 721395 SGTC_2584 androsterone 48.74 µM -0.305357139975297 0.399208976887896 no 2027 0.380047080594852 3073 2754130 A steroid. SGTC_628 1636-0253 16 µM -0.306404119710324 0.398873294184113 no 2028 0.379648486018498 3028 4456143 SGTC_3283 9109332 35.8195 µM -0.308945252817884 0.398058867426602 no 2029 0.378681586351778 2962 17027281 SGTC_3055 9094636 49.47 µM -0.3089701190614 0.398050900045935 no 2030 0.378672128500283 3121 25236176 SGTC_1182 1222-0449 220 µM -0.309434486295314 0.397902120185459 no 2031 0.378495520229893 3023 658318 SGTC_2960 9079389 5.97 µM -0.31278228380782 0.396829950972883 no 2032 0.377223038003285 3118 16457355 SGTC_2850 9015429 58.44 µM -0.314456467298568 0.396294067015896 no 2033 0.376587187382781 3020 6457570 SGTC_3305 9127027 53.8275 µM -0.314902193002657 0.396151429097927 no 2034 0.376417958240424 2982 41905295 SGTC_1167 k781-0610 148 µM -0.315320776037306 0.396017489837929 no 2035 0.376259056008938 2998 4525169 SGTC_1583 clindamycin 39.6 µM -0.316476963828106 0.395647593763559 no 2036 0.375820253760052 2962 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1026 k007-1105 30.6 µM -0.316506624851218 0.395638105626503 no 2037 0.375808998767984 2952 7066794 SGTC_1445 4239-0156 97.7 µM -0.318306346077235 0.395062516476081 no 2038 0.375126285496196 3146 4008346 SGTC_2985 9022375 71.43 µM -0.318342140976257 0.395051070823212 no 2039 0.375112710878507 3159 4939335 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.319812687318254 0.394580932410026 no 2040 0.374555164628413 2940 2346 DNA damaging agent; causes G2/M arrest. SGTC_1197 1601-0112 267 µM -0.320667372220432 0.394307757375233 no 2041 0.374231237860045 2956 7350313 SGTC_1405 3909-7894 12 µM -0.321304716746611 0.394104082660073 no 2042 0.373989741162551 3054 7104060 SGTC_2859 9028643 45.46 µM -0.321595470101203 0.394011176898193 no 2043 0.373879588008013 3036 17151580 SGTC_1079 idarubicin 2.36 µM -0.32223072354158 0.393808212424019 no 2044 0.373638955364751 3106 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2432 5630864 12.22 µM -0.323275089239333 0.393474598651019 no 2045 0.37324345895908 3108 5714970 SGTC_1845 st056753 3.01 µM -0.32424070728931 0.393166209709073 no 2046 0.372877902694392 2926 5375839 SGTC_2306 7482397 179.52 µM -0.324576057115456 0.393059124878224 no 2047 0.372750975289564 3151 891448 SGTC_2180 6301957 200 µM -0.326286419972202 0.39251309313684 no 2048 0.372103830900763 3115 845462 SGTC_1199 1638-0010 4.46 µM -0.326343581954113 0.392494847874399 no 2049 0.372082208934551 2971 3111136 SGTC_3342 9147791 14.508 µM -0.328442399776668 0.391825100068638 no 2050 0.371288594502581 2975 1838168 SGTC_635 k038-0028 24.7 µM -0.329977770765415 0.391335355015474 no 2051 0.370708379310014 3031 4035102 SGTC_2021 4019055 173 µM -0.330229693347914 0.391255014421183 no 2052 0.370613206046636 3148 44827708 YER133W GLC7 SGTC_305 1682-2595 20.8 µM -0.331118152611512 0.390971713061307 no 2053 0.370277620262595 3050 226033 SGTC_2085 5307070 144.047 µM -0.333847698843851 0.390101710180083 no 2054 0.36924724391363 2955 2840351 SGTC_1714 st033236 13.627 µM -0.336048560409642 0.389400618206458 no 2055 0.36841712384914 3195 2916566 SGTC_53 0973-0023 39.979 µM -0.339947876380089 0.388159362599813 no 2056 0.36694789061778 3126 674768 SGTC_421 streptovitacin 30 mM -0.340340748677274 0.388034364032217 no 2057 0.366799966858661 3173 91467 include heat shock SGTC_3206 9114350 49.47 µM -0.34041956475837 0.388009288839434 no 2058 0.366770293512955 3114 17087243 SGTC_1305 1181-0477 144 µM -0.34238600251586 0.387383821652547 no 2059 0.366030210518874 3140 6252086 SGTC_3084 9116877 49.47 µM -0.343719684178715 0.386959782137499 no 2060 0.365528553157696 3080 27241325 SGTC_1809 st050081 57.6 µM -0.346199470663009 0.386171701430506 no 2061 0.364596406251959 3178 5036894 SGTC_3139 9095020 49.47 µM -0.346326611342817 0.386131308511804 no 2062 0.364548635832516 2902 25236292 SGTC_602 3130-1533 38.1 µM -0.347663459502987 0.38570666323319 no 2063 0.364046470894716 3125 720941 SGTC_852 0418-0143 439 µM -0.347774029045068 0.38567154731834 no 2064 0.364004947708845 3119 5369229 SGTC_2959 9079155 11 µM -0.348038555279384 0.385587539913975 no 2065 0.363905614246053 3178 16189457 SGTC_829 1635-0120 117 µM -0.348419596345688 0.385466539532224 no 2066 0.363762543838193 3154 285054 SGTC_2008 4012253 172 µM -0.348439974039578 0.385460068867125 no 2067 0.3637548931112 2991 603940 SGTC_966 1300-0360 30.2 µM -0.353651926576475 0.383806134415677 no 2068 0.361799877072137 3018 70588 SGTC_1106 tegaserod maleate 11.7 µM -0.354130519291181 0.383654365783351 no 2069 0.361620535553596 3064 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2485 5633444 17.78 µM -0.356505065530362 0.382901627385374 no 2070 0.360731179615453 3107 5724239 SGTC_2963 9082507 9 µM -0.356935329316672 0.382765279675409 no 2071 0.360570110221966 3194 16459611 SGTC_869 0564-0080 44.1 µM -0.359867096412808 0.381836609900201 no 2072 0.359473262031438 3076 6843321 SGTC_3288 9119690 36.221 µM -0.362237853859876 0.381086142840891 no 2073 0.358587147155316 3072 17595618 YKL019W RAM2 SGTC_530 4358-1714 28 µM -0.363047109880088 0.380830073751606 no 2074 0.358284846523959 3110 1564641 SGTC_509 pifithrin 175 µM -0.363356441464107 0.380732207189319 no 2075 0.358169317996852 3149 4817 A p53 inhibitor. SGTC_3276 9139060 49.47 µM -0.363770209488164 0.380601310877919 no 2076 0.358014805063599 3005 4870619 SGTC_2208 7283366 200 µM -0.366712425304757 0.379670930189402 no 2077 0.35691676863382 3135 898663 SGTC_141 0443-0274 32.331 µM -0.367104137866931 0.379547116145718 no 2078 0.356770670443984 3200 1627241 SGTC_762 1165-0429 115 µM -0.367896118896618 0.379296821415053 no 2079 0.356475347137288 3165 5967793 SGTC_3073 9114972 49.47 µM -0.368828578929563 0.379002195070629 no 2080 0.356127750640199 3157 41905075 SGTC_49 0717-0965 32.132 µM -0.36897936540092 0.378954558160057 no 2081 0.356071552642131 3310 5889349 YGL099W LSG1 SGTC_553 k007-0256 45.7 µM -0.369310831238572 0.378849846950364 no 2082 0.35594802658021 3100 6287000 SGTC_2414 st077232 92.9 µM -0.369430255536175 0.378812122578291 no 2083 0.355903524904499 2993 729801 SGTC_1462 k081-0014 26.5 µM -0.369810689036591 0.378691956951794 no 2084 0.355761775150392 3065 3270634 SGTC_1734 st037168 69.4 µM -0.369961059472328 0.378644463427521 no 2085 0.355705752532099 3138 708907 SGTC_796 1234-0020 70.7 µM -0.370016802440735 0.378626857839039 no 2086 0.355684985497855 3050 46495034 SGTC_1778 st046819 58.9 µM -0.371655661112674 0.378109361385331 no 2087 0.355074620606012 3064 671715 SGTC_1606 st000094 49.2 µM -0.371942925142899 0.378018675556898 no 2088 0.35496767227122 3199 1242210 SGTC_2203 7227154 166.4 µM -0.374025608663275 0.377361398496128 no 2089 0.35419263185751 3108 896304 SGTC_963 1269-2853 151 µM -0.37438286294934 0.377248687732468 no 2090 0.354059745425166 3052 3668223 SGTC_2270 7924575 90.91 µM -0.375225676400228 0.376982828526422 no 2091 0.35374631795987 3202 1262135 SGTC_1056 3448-1962 115 µM -0.375928739596196 0.376761097098322 no 2092 0.353484936960138 3138 715507 SGTC_38 0929-0051 58.268 µM -0.377268356862694 0.376338722389296 no 2093 0.352987092649208 3185 1379719 SGTC_9 0092-0002 10.449 µM -0.377282002996286 0.376334420591617 no 2094 0.352982022605622 3139 759368 SGTC_561 1550-0330 72.9 µM -0.378716569025934 0.375882274779541 no 2095 0.352449174007756 3078 6812934 SGTC_2282 7944268 200 µM -0.380304710207318 0.375381923925394 no 2096 0.3518596197494 3275 2970414 SGTC_571 k831-0106 44.2 µM -0.380444599272012 0.375337861291715 no 2097 0.351807706775353 3197 4783639 SGTC_2818 7996756 12.99 µM -0.381201170283575 0.375099582718303 no 2098 0.351526990402871 2993 2241621 SGTC_224 benfluorex 43.875 µM -0.381833087093523 0.374900599936598 no 2099 0.351292587475012 3184 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_62 0180-0423 3.232 µM -0.383031929646937 0.374523190798295 no 2100 0.350848044854098 3122 30102 YGL099W LSG1 SGTC_3183 9108214 49.47 µM -0.383477236473049 0.374383033785443 no 2101 0.350682972652524 3154 4974831 SGTC_2078 5212016 200 µM -0.384059174444506 0.374199898156181 no 2102 0.350467294707282 3136 1899708 SGTC_3322 9139058 2.11 µM -0.384227553428818 0.374146914655057 no 2103 0.350404899048538 3245 4908926 YPR165W RHO1 SGTC_3303 9125618 40.5795 µM -0.384520289155873 0.374054805709135 no 2104 0.350296430521813 3137 22695467 SGTC_3236 9132701 49.47 µM -0.385273244469192 0.373817922264909 no 2105 0.350017491118084 3153 24282524 SGTC_2953 9074162 66.49 µM -0.3858644733282 0.373631952152957 no 2106 0.349798521505546 3198 16451992 SGTC_1503 4585-0012 61.3 µM -0.387629246956389 0.373077020502786 no 2107 0.349145211018146 3247 2922052 SGTC_361 000s-0510 1.45 µM -0.38787161844005 0.373000827516158 no 2108 0.349055521144504 3157 660 SGTC_84 0443-0269 128.823 µM -0.388096333768806 0.372930189435077 no 2109 0.348972372485524 3203 6150058 SGTC_1121 fusaric acid 630.51 nM -0.38884328179358 0.372695420966817 no 2110 0.348696040592186 3081 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_723 4182-0001 115 µM -0.389798854333158 0.372395150003852 no 2111 0.348342645502173 3101 744821 YLR208W SEC13 SGTC_1211 1056-0033 32.3 µM -0.390028757132689 0.372322918876546 no 2112 0.34825764121557 3220 6741922 SGTC_3345 9148410 3.559 µM -0.39217714653459 0.371648152814724 no 2113 0.347463664393535 3212 4903596 SGTC_61 0978-8327 98.565 µM -0.392635107183846 0.371504367447235 no 2114 0.347294502968463 3205 6150059 YHR072W ERG7 SGTC_1350 1495-0454 146 µM -0.392816290898027 0.37144748635744 no 2115 0.347227585754675 3246 1069057 SGTC_1833 st055984 71 µM -0.392827464014522 0.371443978744197 no 2116 0.347223459304428 3112 676288 SGTC_2980 9014342 25.29 µM -0.394973221286002 0.370770552311734 no 2117 0.346431325459132 3244 2996599 SGTC_3146 9095609 49.47 µM -0.395191556249543 0.370702052011188 no 2118 0.346350761867423 3142 17173999 SGTC_1670 st016595 4.04 µM -0.399645429928782 0.369305593285893 no 2119 0.344708845217032 3178 597879 SGTC_1312 1218-2183 165 µM -0.40264674941891 0.368365535892857 no 2120 0.343604056532188 3180 6744073 SGTC_878 0828-0289 13.7 µM -0.402974834453944 0.368262822479756 no 2121 0.343483368855533 3127 745350 YLR208W SEC13 SGTC_3221 9128209 49.47 µM -0.403250271144125 0.368176598926515 no 2122 0.343382060448271 3129 16460723 SGTC_111 0083-0039 52.457 µM -0.40509346133593 0.367599772047932 no 2123 0.342704406302143 3053 759313 SGTC_2996 9066192 71.4286 µM -0.405165492249496 0.367577236007102 no 2124 0.342677934187481 3142 6472854 SGTC_2957 9076800 11.52 µM -0.405839690458321 0.367366324268567 no 2125 0.342430196760965 3138 16459615 SGTC_252 miconazole 1.30953 nM -0.407589857282654 0.366819000447215 no 2126 0.341787405976506 3185 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1073 triclabendazole 3.09 µM -0.407740263921987 0.366771976894686 no 2127 0.341732186892392 3200 50248 An antihelmetic and likely tubulin inhibitor. SGTC_658 3253-0951 102 µM -0.408135736018451 0.366648344933114 no 2128 0.34158701260718 3158 1184878 SGTC_1155 4088-0394 48.2 µM -0.408838203323463 0.366428774654969 no 2129 0.341329200898623 3104 2326248 SGTC_67 0335-0847 266 µM -0.408879669310352 0.366415814992868 no 2130 0.341313984827956 3388 4552207 YOR254C SEC63 SGTC_2389 9091542 195.52 µM -0.409008336795289 0.366375602591295 no 2131 0.34126677154329 3160 3626624 YOL127W RPL25 SGTC_1166 k206-0078 225 µM -0.40957524536356 0.366198444343646 no 2132 0.341058779545666 3111 5404595 SGTC_1181 1222-0449 220 µM -0.409916585484553 0.366091789716622 no 2133 0.340933569210113 3282 658318 SGTC_2513 baicalein 25.65 µM -0.410137829375445 0.36602266570461 no 2134 0.340852421913382 3158 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_940 3232-1287 54.8 µM -0.410189944236214 0.366006383906868 no 2135 0.340833308422717 3227 1585493 YIL048W NEO1 SGTC_814 3342-0569 96 µM -0.411335063293109 0.36564868515712 no 2136 0.340413431177808 3216 4346283 SGTC_86 0417-1630 471.922 µM -0.412062297585892 0.365421580925117 no 2137 0.340146881070513 3218 3634867 SGTC_2342 7990637 118.86 µM -0.412090423443093 0.365412798593852 no 2138 0.340136573822466 3229 2033102 YER133W GLC7 SGTC_2933 9026794 32.47 µM -0.412530803788854 0.365275298529412 no 2139 0.339975203766021 3144 17586027 SGTC_2034 5197015 53.07 µM -0.415779930610385 0.364261359101214 no 2140 0.338785522939393 3279 780676 SGTC_254 nsc-64875 3.808 µM -0.418554148809196 0.363396373029515 no 2141 0.337771002517833 3292 56993 SGTC_2528 xanthyletin 44.79 µM -0.419283916889282 0.363168950782981 no 2142 0.337504324593166 3101 65188 An natural product with antifungal activity of unknown mechanism. SGTC_165 k038-0023 64.381 µM -0.419894863286186 0.36297859477813 no 2143 0.337281130213148 3144 46368543 SGTC_820 1582-0060 59.9 µM -0.420230873010342 0.362873916762628 no 2144 0.337158401644638 3145 3848840 SGTC_992 3909-8734 162 µM -0.422326720289515 0.362221223341905 no 2145 0.336393278661026 3176 4288319 SGTC_77 0828-0286 12.516 µM -0.424227495840206 0.361629625721816 no 2146 0.335699955054718 3235 745345 SGTC_1256 0570-0116 285 µM -0.424669822786475 0.361492003194312 no 2147 0.335538692722118 3165 410638 SGTC_3278 9139605 49.47 µM -0.425401567990251 0.361264372430881 no 2148 0.335271981595897 3309 7958859 SGTC_1012 4112-3522 18 µM -0.428272084919819 0.360371888999273 no 2149 0.334226520031631 3297 3112398 SGTC_2526 patulin 37.61 µM -0.428296702343104 0.360364238382907 no 2150 0.334217559745491 3292 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1271 0832-2808 169 µM -0.430099148400074 0.359804225297928 no 2151 0.333561759742666 3278 3663794 SGTC_1913 st060213 96.1 µM -0.430605521108776 0.359646951317168 no 2152 0.333377613015757 3325 688959 SGTC_668 1682-0499 62.6 µM -0.43090550730107 0.359553790003598 no 2153 0.333268539429781 3215 682214 SGTC_1622 st003707 19.4 µM -0.433404954789041 0.358777906521614 no 2154 0.332360300788498 3268 10140899 SGTC_3057 9095946 49.47 µM -0.435138692722685 0.358240058000537 no 2155 0.331730879776254 3188 24540043 SGTC_286 k060-0067 22.9 µM -0.435778434667018 0.358041665136477 no 2156 0.331498745900548 3193 5985051 SGTC_1098 clofazimine 15.1 µM -0.436884779589773 0.357698662691211 no 2157 0.331097455326548 3281 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_682 0kpi-0099 17 µM -0.439192658989446 0.356983516051059 no 2158 0.330260971905552 3268 1714895 YML126C ERG13 SGTC_2715 st079500 56.4 µM -0.439559703229438 0.35686982563398 no 2159 0.330128015920535 3143 28246688 SGTC_3097 9117246 49.47 µM -0.440079156621073 0.356708948846391 no 2160 0.329939888786145 3249 16423892 SGTC_464 bw-b 70c 158 µM -0.441131533911247 0.356383101544147 no 2161 0.329558887837761 3285 5353454 SGTC_1481 3346-2004 36 µM -0.441322107701654 0.356324105434585 no 2162 0.329489911716042 3272 2770522 SGTC_2943 9068529 45.32 µM -0.44218250272316 0.356057794953746 no 2163 0.329178573291137 3243 3270634 SGTC_3099 9120367 49.47 µM -0.443614215655219 0.355614805145793 no 2164 0.328660763083375 3201 24824940 SGTC_2923 7992654 58.14 µM -0.444453521743692 0.355355203990329 no 2165 0.328357362536244 3198 2985126 SGTC_1255 0566-0045 221 µM -0.446044884898389 0.354863172508769 no 2166 0.327782411884775 3338 2788469 SGTC_1883 5-benzylidenerhodanine 20 µM -0.447638295065878 0.35437075054607 no 2167 0.327207130413211 3279 1273210 SGTC_3160 9100216 49.47 µM -0.447906941993264 0.354287752780222 no 2168 0.327110179065245 3259 17191039 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.448067249949318 0.354238229352949 no 2169 0.327052331466903 3290 140250 A respiratory chain inhibitor. SGTC_1987 st072290 61.9 µM -0.448297761484599 0.354167022477817 no 2170 0.326969157983195 3222 54697379 SGTC_2568 diosmetin 100 µM -0.44857972668052 0.354079928084637 no 2171 0.326867430606743 3350 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_582 0987-0078 156 µM -0.449274372404281 0.353865396066068 no 2172 0.326616871294367 3330 1625765 SGTC_2204 7233102 200 µM -0.449324173616801 0.353850017410676 no 2173 0.32659891095641 3197 2172480 SGTC_359 0081-0058 15.9 µM -0.452225127479023 0.35295461272653 no 2174 0.325553403997913 3517 3494159 SGTC_1417 3966-0327 90.4 µM -0.452646519979641 0.352824613828981 no 2175 0.325401647525859 3260 651118 SGTC_1568 digitonin 820 nM -0.46031245111171 0.350462699463907 no 2176 0.322645982639861 3367 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3114 9122766 49.47 µM -0.461019004886458 0.350245295523775 no 2177 0.322392485052049 3260 17176985 SGTC_24 0417-1663 219 µM -0.461595951158562 0.350067807708707 no 2178 0.322185549312631 3294 4329390 SGTC_10 0279-0212 42.575 µM -0.462220167142827 0.349875815044398 no 2179 0.321961721208815 3251 39851 YBR002C RER2 SGTC_908 3448-7491 47.7 µM -0.463164453735357 0.349585449906452 no 2180 0.321623246604831 3210 1203031 SGTC_369 0957-0393 4.5 µM -0.463803990816267 0.349388844237338 no 2181 0.321394091922362 3258 6997992 SGTC_1001 4048-4355 44.4 µM -0.46498152905719 0.349026952651842 no 2182 0.320972342055617 3207 21824233 SGTC_1460 k062-0059 9.15 µM -0.465146672026891 0.348976210405089 no 2183 0.3209132125092 3164 1373085 SGTC_515 4092-1064 102 µM -0.468049508089411 0.348084719305631 no 2184 0.319874592918336 3410 717353 SGTC_2094 5332512 191.667 µM -0.468390769379993 0.347979969434542 no 2185 0.319752583914279 3351 755774 SGTC_2031 5180455 200 µM -0.469627194822567 0.347600546865279 no 2186 0.319310695898303 3235 29949 SGTC_2950 9072895 21.46 µM -0.470199692429937 0.34742491587154 no 2187 0.319106176937294 3329 17332245 SGTC_2011 4012611 177 µM -0.470612060311766 0.347298429814078 no 2188 0.318958896797659 3201 2049887 SGTC_1937 st074714 47.2 µM -0.471950078795958 0.346888135088089 no 2189 0.318481210832042 3202 17250970 SGTC_397 arbidol 50 µM -0.472837320228304 0.34661616715995 no 2190 0.318164623012909 3357 131410 A RNA synthesis inhibitor. SGTC_2839 9003951 25.97 µM -0.473400277304478 0.346443643752024 no 2191 0.317963816034218 3321 2990634 SGTC_1251 0490-5699 265 µM -0.474262493476939 0.346179471380569 no 2192 0.317656366987673 3411 3883818 SGTC_1924 st058459 75.1 µM -0.474653700995695 0.346059634905525 no 2193 0.31751691165187 3313 688683 SGTC_1936 st074407 74.3 µM -0.4751006516471 0.345922741805791 no 2194 0.317357617025587 3221 809813 SGTC_1957 st077035 62.4 µM -0.475931541357469 0.345668308469868 no 2195 0.317061575204324 3348 705593 SGTC_2107 5363541 170.161 µM -0.476559373726236 0.345476101155393 no 2196 0.316837959317646 3336 244052 SGTC_182 3448-4371 550.524 µM -0.47840582856387 0.34491105051176 no 2197 0.3161806929835 3362 3491403 SGTC_3082 9117008 49.47 µM -0.481957756807371 0.343825065256203 no 2198 0.314917977675618 3275 41448529 SGTC_1064 honokiol 6.76 µM -0.482065134039382 0.343792255178166 no 2199 0.314879838494985 3307 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3127 9126946 49.47 µM -0.485410072332454 0.342770769470552 no 2200 0.313692744474219 3270 27243249 SGTC_1762 st045503 25.4615 µM -0.485592520397947 0.342715085982617 no 2201 0.313628050292446 3321 4645554 SGTC_1776 st049249 45.9 µM -0.486108168547259 0.342557727691612 no 2202 0.313445237830104 3297 1822314 SGTC_2764 methyldopa 94.69 µM -0.486637600969934 0.342396191334312 no 2203 0.313257586108803 3413 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1709 st033179 39.1045 µM -0.487638100769641 0.342091005244953 no 2204 0.312903101564677 3256 573381 SGTC_2061 5245884 80.95 µM -0.488082818529459 0.341955384465486 no 2205 0.312745590236625 3252 573863 SGTC_1368 1852-0141 284 µM -0.488476556982537 0.341835327312448 no 2206 0.312606163427287 3338 2838987 SGTC_197 4544-0043 41.561 µM -0.488578141229733 0.341804355245441 no 2207 0.312570195758097 3326 896523 SGTC_2581 avocatin a 64 µM -0.488607191306502 0.34179549835019 no 2208 0.312559910401481 3251 6710728 A skin care supplement. SGTC_1969 st069479 40.1 µM -0.489137318983576 0.341633886354449 no 2209 0.312372241115877 3368 3895485 SGTC_1832 st054113 55 µM -0.493680778053639 0.340249983884164 no 2210 0.310765821246145 3364 1251267 SGTC_1816 st051957 91.6 µM -0.495424458614582 0.339719441855086 no 2211 0.310150266647386 3317 674121 SGTC_2884 9058502 51.95 µM -0.495919035677616 0.339569016795746 no 2212 0.30997576761477 3367 6471554 SGTC_2316 5844804 197.44 µM -0.496361394814411 0.339434495407583 no 2213 0.309819728613694 3335 776813 SGTC_1130 3454-2858 15.9 µM -0.497162505615836 0.339190929738377 no 2214 0.309537229759272 3290 715628 YIL048W NEO1 SGTC_1280 0880-0253 10.1 µM -0.497625751706351 0.339050117394147 no 2215 0.309373924790573 3291 6836607 SGTC_2796 7949634 45.45 µM -0.498048794770826 0.338921545153086 no 2216 0.309224825201308 3290 2971588 SGTC_1944 st076371 56.9 µM -0.498783251329477 0.338698371960698 no 2217 0.308966043971129 3243 24208455 SGTC_2455 5377712 9.75 µM -0.49967845011917 0.338426431934802 no 2218 0.308650754388778 3319 2243908 SGTC_1506 4226-2149 212 µM -0.499812325061608 0.338385771160294 no 2219 0.308603615664307 3352 991114 SGTC_1795 st049545 62.3 µM -0.501617563610265 0.337837664564056 no 2220 0.307968281146889 3357 5291882 SGTC_707 0865-0008 204 µM -0.50277479553428 0.337486486456113 no 2221 0.307561308049411 3295 723043 SGTC_2686 alizarin 95.37 µM -0.507685790035947 0.335997754387277 no 2222 0.305836857700349 3295 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1565 sinapyl alcohol 95.1 µM -0.511285105536531 0.334908278097268 no 2223 0.304575716475524 3360 5280507 A phenol propionate derived from cinnamic acid. SGTC_510 ag-490 170 µM -0.51136606158182 0.334883789449979 no 2224 0.304547377420285 3443 5328779 SGTC_3153 9100258 49.47 µM -0.515346815059698 0.333680506701129 no 2225 0.303155345237339 3279 25236848 SGTC_2327 6189656 200 µM -0.515867378294771 0.333523279456928 no 2226 0.302973519727653 3378 5349088 SGTC_671 0560-0003 407 µM -0.517691340146357 0.332972613741269 no 2227 0.302336820631238 3303 3238678 SGTC_3066 9117245 49.47 µM -0.517757668747126 0.332952595490489 no 2228 0.302313678303192 3323 17176980 SGTC_560 2332-1943 155 µM -0.521185567080421 0.33191869055182 no 2229 0.30111875372254 3394 21177716 SGTC_3053 9095903 49.47 µM -0.521945957782233 0.331689518441612 no 2230 0.300853979251884 3417 17174018 SGTC_532 1548-0774 215 µM -0.522040303193784 0.331661088321648 no 2231 0.300821134706309 3514 5932993 SGTC_3133 9127736 49.47 µM -0.525378644324781 0.330655735204114 no 2232 0.299659998121865 3441 27243420 SGTC_2964 9083345 53.42 µM -0.525582864846051 0.330594273023603 no 2233 0.299589032408473 3324 17741579 SGTC_160 3453-0671 289.699 µM -0.526480395335827 0.33032420654194 no 2234 0.299277234921681 3339 5322268 SGTC_806 3966-4455 5.86 µM -0.526839839166904 0.330216074840924 no 2235 0.299152407276595 3313 714982 SGTC_2181 6316240 54.2555 µM -0.527388310005714 0.33005110535887 no 2236 0.298961979890434 3382 12779990 SGTC_775 4577-0580 57.3 µM -0.528110305148592 0.329833993479778 no 2237 0.298711389374364 3498 2006902 SGTC_1063 disulfiram 1.84 µM -0.528130711454081 0.329827857911888 no 2238 0.298704308129101 3371 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2924 9010168 62.78 µM -0.528217465558572 0.329801774049328 no 2239 0.298674204213057 3394 2993929 SGTC_1514 1189-1591 158 µM -0.52826030351534 0.329788894510056 no 2240 0.298659339831418 3461 767698 YMR146C TIF34 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.528636712767318 0.329675733045031 no 2241 0.298528743707516 3448 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_923 1900-2434 73.3 µM -0.529558286488751 0.329398742370775 no 2242 0.298209111131959 3389 5910570 SGTC_1912 st060209 90.8 µM -0.529721828400934 0.32934959754804 no 2243 0.298152405616983 3335 688787 SGTC_1355 1499-0035 1.68 µM -0.529827063634241 0.329317975611519 no 2244 0.298115919597979 3364 1548538 SGTC_661 1304-0007 33.6 µM -0.530227641119936 0.32919761800913 no 2245 0.297977054327625 3350 3117130 SGTC_3211 9128781 49.47 µM -0.531115809505068 0.328930821878968 no 2246 0.297669264691179 3340 17194361 SGTC_1922 5578187 25 µM -0.531345706386391 0.328861777545149 no 2247 0.297589618893714 3488 1350412 SGTC_1077 5-fluorocytosine 377 nM -0.533763280796222 0.328136067683212 no 2248 0.296752660672331 3396 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2005 4024620 188 µM -0.536103666917989 0.327434145678914 no 2249 0.29594345299145 3424 236743 SGTC_1699 st031318 29.054 µM -0.53778665378564 0.326929765640351 no 2250 0.295362173483831 3425 5340658 SGTC_2808 7946468 45.46 µM -0.538257079118812 0.326788838749954 no 2251 0.29519978931417 3373 2970879 SGTC_2848 9016370 25.97 µM -0.538368292652665 0.326755525749708 no 2252 0.295161405983268 3476 7894410 SGTC_2222 6885208 172.143 µM -0.542160417332322 0.325620457225103 no 2253 0.29385400037819 3396 609514 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.542195889645687 0.325609847169237 no 2254 0.293841783293229 3394 676296 Flavone; oxidizing agent. SGTC_1322 1348-1070 12 µM -0.542490902725294 0.325521611845192 no 2255 0.293740186397833 3437 6758089 SGTC_100 0086-0128 49.5915 µM -0.542736929398772 0.325448035318643 no 2256 0.293655471922109 3391 93297 SGTC_1252 0493-0875 34.8 µM -0.546142131838173 0.324430378043675 no 2257 0.292484120297186 3363 3960963 SGTC_921 1561-0023 372 µM -0.547072236825496 0.324152640160309 no 2258 0.292164552578346 3430 24050882 SGTC_385 1494-0393 12.4 µM -0.548657619903937 0.323679455785101 no 2259 0.291620217641235 3384 3090647 SGTC_1168 k815-0004 80.5 µM -0.550493707838183 0.323131800361805 no 2260 0.290990395711576 3357 642433 SGTC_2365 9042475 200 µM -0.552135742015279 0.322642350409416 no 2261 0.290427677759301 3436 6464479 SGTC_2139 5578692 56.4705 µM -0.55244918137061 0.322548956741809 no 2262 0.290320321387305 3403 650991 YMR113W FOL3 SGTC_330 1488-0319 80.1 µM -0.552534994996924 0.322523389315952 no 2263 0.290290932532284 3419 6846614 SGTC_1874 staurosporine 7.6 µM -0.554764535896994 0.321859411402948 no 2264 0.289527863684191 3454 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1409 3909-8004 61.9 µM -0.556674624495397 0.321291021282477 no 2265 0.288874878694461 3416 2119279 SGTC_1382 3002-2117 298 µM -0.557849769230128 0.320941538097546 no 2266 0.288473487119669 3513 1497314 SGTC_3330 9141424 71.43 µM -0.558836056024468 0.32064834286629 no 2267 0.288136806348909 3452 27261020 SGTC_2643 anethole 100 µM -0.558972499568111 0.320607790854963 no 2268 0.288090244319018 3449 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1796 st049173 110.4 µM -0.559008550693171 0.320597076556555 no 2269 0.288077942288461 3441 94134 SGTC_1008 4106-0037 6 µM -0.55951926868252 0.320445308591507 no 2270 0.28790369230462 3446 2905394 SGTC_2155 5570423 76 µM -0.559561808818971 0.320432668468192 no 2271 0.287889180438369 3355 797402 SGTC_3256 9138902 49.47 µM -0.560085103802085 0.320277196751615 no 2272 0.287710695247375 3432 17228773 SGTC_3158 9100007 49.47 µM -0.561472356350551 0.31986519466559 no 2273 0.287237785053248 3383 19297233 SGTC_1075 aripiprazole 15.2 µM -0.56192689472402 0.319730248961498 no 2274 0.287082914354622 3413 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2281 7943571 200 µM -0.562896846591954 0.319442364430406 no 2275 0.28675256381451 3523 1244024 SGTC_1747 st037496 66.6 µM -0.563101688786144 0.319381580581111 no 2276 0.286682820799242 3402 723305 SGTC_2942 9052777 62.25 µM -0.565373021793305 0.318707922152622 no 2277 0.285910035245234 3500 6469503 SGTC_155 k072-0202 43.6 µM -0.56705040696161 0.318210807858843 no 2278 0.285339967647203 3443 5857737 SGTC_2539 epi(13)torulosol 80 µM -0.568812835367145 0.317688842459364 no 2279 0.284741581588452 3444 6708597 SGTC_1767 st044992 70.3 µM -0.569524336376321 0.317478225011837 no 2280 0.284500180009641 3423 9600693 SGTC_2993 9054257 71.4286 µM -0.57012089288383 0.317301678786304 no 2281 0.284297852742746 3446 6470217 YGL055W OLE1 SGTC_1363 1636-0063 10.4 µM -0.57191847626999 0.316769949496031 no 2282 0.283688603094856 3451 6072185 SGTC_728 3030-5151 22.5 µM -0.572401403386235 0.316627162972495 no 2283 0.283525032657659 3489 3125388 SGTC_3321 9137793 26.8275 µM -0.57404866038178 0.316140325958695 no 2284 0.282967436661527 3471 4904192 SGTC_3182 9108849 49.47 µM -0.574255146857228 0.316079322562769 no 2285 0.282897578202757 3508 17133045 SGTC_1914 st062367 72.6 µM -0.57456085125671 0.315989015882903 no 2286 0.282794167567756 3415 978205 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.574704298719855 0.315946644535768 no 2287 0.28274564985097 3538 165506 SGTC_2320 7373003 200 µM -0.577410128997335 0.315147852966522 no 2288 0.281831216676288 3450 5415828 SGTC_2087 5276107 200 µM -0.577586275432001 0.315095882454915 no 2289 0.281771737573132 3467 144405 SGTC_927 2425-1185 123 µM -0.578438428160954 0.314844513715268 no 2290 0.281484077903896 3407 730375 SGTC_2822 7994718 71.43 µM -0.578802886565076 0.314737031638854 no 2291 0.281361091605028 3455 1018011 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.579180584459142 0.314625661676049 no 2292 0.281233665019119 3518 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3089 9117425 49.47 µM -0.580847818756622 0.314134253927479 no 2293 0.280671511726055 3438 9401657 SGTC_2254 7938975 95.19 µM -0.582477618087522 0.313654198198596 no 2294 0.280122506582232 3566 2969277 SGTC_2441 5730946 39.09 µM -0.582543895779223 0.313634682840251 no 2295 0.280100191663835 3503 1774275 SGTC_2221 6807166 181.081 µM -0.583431757606169 0.313373303679396 no 2296 0.27980134214277 3461 674925 SGTC_2894 9048625 32.47 µM -0.585108543818083 0.312879927389785 no 2297 0.279237367181069 3564 4092861 SGTC_1051 3253-3903 78 µM -0.585675384406127 0.31271321636342 no 2298 0.279046839460927 3429 5509239 SGTC_1558 st069300 45.6 µM -0.586064329158505 0.312598847666306 no 2299 0.278916143067377 3477 24208000 SGTC_2654 protoveratrine a 100 µM -0.587065008059477 0.312304682290694 no 2300 0.278580023707771 3455 5702278 A heart drug and vasodilator. SGTC_2648 atorvastatin 78.68 µM -0.588739319497082 0.311812759505862 no 2301 0.278018078589396 3517 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2564 betulinic acid 100 µM -0.590090556938292 0.311416002422257 no 2302 0.277564969683407 3566 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3155 9099265 49.47 µM -0.591905592662759 0.310883407142934 no 2303 0.276956904281765 3461 25236499 SGTC_1862 st057513 3.81 µM -0.592167799286545 0.310806499207823 no 2304 0.276869114898517 3459 5393163 SGTC_2235 salicylic acid 500 µM -0.594087739734361 0.310243612660573 no 2305 0.276226715298796 3493 338 A COX inhibitor and kinase inhibitor. SGTC_13 0199-0087 65 µM -0.59510102821198 0.309946716597816 no 2306 0.275887970696577 3524 4589825 SGTC_445 e6 berbamine 66 µM -0.596671454559934 0.309486822587517 no 2307 0.27536337722915 3515 6610268 A calcium/calmodulin antagonist. SGTC_2827 7993847 71.43 µM -0.596923680343382 0.309412986899417 no 2308 0.275279168174804 3480 2985692 SGTC_1637 st007924 17.4 µM -0.597700240391166 0.309185707763295 no 2309 0.275019982516438 3504 683336 SGTC_3293 9120939 62.045 µM -0.600532999096697 0.308357251584468 no 2310 0.274075537742652 3527 934087 SGTC_1480 1070-0044 41.2 µM -0.602664332939233 0.307734573503461 no 2311 0.273366006771017 3496 3124987 SGTC_1234 0326-0494 15.5 µM -0.602987359276628 0.307640248258546 no 2312 0.27325854922772 3574 1547813 SGTC_2234 tolnaftate 200 µM -0.603337346020246 0.307538064796304 no 2313 0.273142146690776 3472 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1221 2958-7315 257 µM -0.603757298746557 0.307415473508153 no 2314 0.273002506517169 3528 4562705 SGTC_3223 9129970 49.47 µM -0.60443828193442 0.307216728748699 no 2315 0.272776145306021 3539 17248386 SGTC_420 mitomycin C 81.9 mM -0.604746500483431 0.307126793854581 no 2316 0.272673722992886 3509 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_508 roscovitine 141 µM -0.604752838682856 0.307124944557126 no 2317 0.272671616982993 3531 160355 A CDKinase inhibitor. SGTC_187 1488-2104 32.728 µM -0.605223962401811 0.306987498452017 no 2318 0.272515098092143 3543 2852859 SGTC_2332 7982454 138.89 µM -0.605452692066527 0.306920778409594 no 2319 0.272439124559647 3521 2981748 SGTC_959 1222-0044 107 µM -0.605596240655671 0.306878908803333 no 2320 0.272391449657225 3520 6083612 SGTC_326 k292-0812 17.5 µM -0.605655295557926 0.306861684666576 no 2321 0.272371837733411 3507 3579357 SGTC_2863 9028737 58.44 µM -0.605846349999775 0.306805964053954 no 2322 0.272308394035884 3461 6460917 SGTC_2472 5377652 49.4 µM -0.606114868397606 0.306727658792203 no 2323 0.272219239194585 3501 1610903 SGTC_2474 5321570 43.32 µM -0.607101084454193 0.306440134440408 no 2324 0.271891915269368 3498 2841384 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.60759819066753 0.306295251765286 no 2325 0.27172700056758 3572 23847180 SGTC_3296 9122258 64.045 µM -0.612140246529474 0.304972864513944 no 2326 0.270222485792541 3524 4730474 SGTC_870 0573-2213 57.6 µM -0.612547924080985 0.304854296210796 no 2327 0.27008765031234 3551 3916321 SGTC_2793 7325131 81.82 µM -0.612990802344642 0.30472551340716 no 2328 0.269941210684356 3481 4176441 SGTC_825 1988-2224 89.6 µM -0.613305305970012 0.304634074842211 no 2329 0.269837242825746 3520 1180859 SGTC_2196 6573537 42.6665 µM -0.613705258679319 0.304517810500361 no 2330 0.269705056377813 3579 2903087 SGTC_924 2046-0044 21.3 µM -0.613927345782708 0.304453259367052 no 2331 0.269631669444347 3557 3623589 SGTC_1708 st033234 31.827 µM -0.61481802118271 0.30419443968909 no 2332 0.269337453324018 3586 674664 SGTC_2024 5144227 134 µM -0.615342376413188 0.304042114149194 no 2333 0.269164318778914 3524 3475211 SGTC_3134 9127454 49.47 µM -0.615418257017653 0.304020073599999 no 2334 0.269139268721722 3625 24262820 SGTC_821 1114-0266 29.2 µM -0.616761767428547 0.303629950816455 no 2335 0.268695936623907 3535 3123235 SGTC_2177 5811945 192 µM -0.617114110746349 0.303527675879839 no 2336 0.268579730994605 3572 5343475 SGTC_2602 kawain 100 µM -0.617229985898765 0.303494044082107 no 2337 0.268541519967674 3541 5369129 SGTC_2883 9059145 45.46 µM -0.61801431334349 0.303266443351852 no 2338 0.268282951769124 3518 16476510 SGTC_1308 1187-1617 41.4 µM -0.620443066258812 0.302562138099482 no 2339 0.267483063198578 3544 2882570 SGTC_702 1488-0190 94 µM -0.62312882875266 0.301784158359288 no 2340 0.266599933256436 3550 949357 SGTC_1357 1503-1303 39.5 µM -0.623899450453851 0.301561099959597 no 2341 0.266346810619123 3556 292895 SGTC_609 0986-0026 86.3 µM -0.625107984852992 0.301211436078499 no 2342 0.265950093830607 3542 2848610 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.626343164295489 0.300854251858388 no 2343 0.265544940043269 3448 6708630 An antioxidant. SGTC_780 0109-0199 192 µM -0.626371686594746 0.300846006151829 no 2344 0.265535588084027 3606 610414 SGTC_1784 st039334 36.3 µM -0.627094665689214 0.300637029231084 no 2345 0.265298591785427 3641 3496984 SGTC_2129 girgensonine 121.053 µM -0.629535886259516 0.299931879750331 no 2346 0.264499141218449 3561 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_604 1000-0114 314 µM -0.633712142818468 0.29872730204469 no 2347 0.263134349448713 3609 1572745 SGTC_596 1155-0152 116 µM -0.633833856267201 0.298692228652627 no 2348 0.263094627779607 3578 280313 SGTC_2257 7960413 200 µM -0.634278607246066 0.298564083507865 no 2349 0.262949507583628 3558 2974689 YIL048W NEO1 SGTC_1351 1496-0003 46.5 µM -0.634610162488995 0.298468569479817 no 2350 0.262841349265059 3581 3891978 SGTC_2265 7929201 200 µM -0.635961923781358 0.298079299714304 no 2351 0.262400619934022 3569 1265108 SGTC_1408 3909-7976 48.8 µM -0.636360030015165 0.297964700270806 no 2352 0.262270893230446 3578 24152374 SGTC_468 gf-109203x 121 µM -0.636820991091592 0.29783203243608 no 2353 0.262120725731763 3492 2396 A protein kinase C inhibitor. SGTC_2117 5521686 200 µM -0.637842786596804 0.297538048598254 no 2354 0.261788012108196 3558 803312 SGTC_1684 st024538 14.6195 µM -0.638797687570667 0.297263431000731 no 2355 0.261477276404178 3536 6732859 SGTC_649 1123-0311 367 µM -0.639826049290448 0.296967816615964 no 2356 0.261142847651702 3571 693629 YIL048W NEO1 SGTC_125 0133-0007 11.75 µM -0.640008738043705 0.296915314707025 no 2357 0.261083459292533 3637 26541 SGTC_406 estrone 100 µM -0.640010948400111 0.296914679510944 no 2358 0.261082740793602 3602 5870 A steroid. SGTC_3110 9122132 49.47 µM -0.6415581488391 0.296470208977806 no 2359 0.260580056966777 3652 918317 SGTC_2058 5236698 133 µM -0.642446028753679 0.296215281899979 no 2360 0.260291810872583 3571 766665 SGTC_2532 xanthone 78.9 µM -0.64402533911562 0.29576208076755 no 2361 0.259779501398361 3502 7020 An insecticide. SGTC_248 streptozotocin 5.23457 mM -0.644512037089815 0.295622481472159 no 2362 0.259621727317111 3615 5300 DNA alkylating agent. SGTC_1243 0416-0003 5.65 µM -0.644727587694687 0.295560664897329 no 2363 0.259551867555864 3551 2141977 SGTC_2937 9044753 11.33 µM -0.645700331359924 0.295281771039024 no 2364 0.259236722976189 3588 6465530 YGL099W LSG1 SGTC_2111 5486399 200 µM -0.645981567506742 0.295201160827284 no 2365 0.259145646377578 3602 689674 SGTC_3173 9105693 49.47 µM -0.646961002743262 0.294920506173834 no 2366 0.258828591460595 3644 17096658 SGTC_2769 toremifene 3.73 µM -0.647855511675822 0.294664294416447 no 2367 0.258539203674038 3619 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2010 4012422 159 µM -0.648483568767607 0.294484463105184 no 2368 0.258336117446785 3559 952393 SGTC_3015 9080845 49.47 µM -0.649317513105198 0.2942457585042 no 2369 0.258066584090783 3625 5296973 SGTC_1048 3161-0300 24.5 µM -0.650607385451832 0.293876727191749 no 2370 0.257649980823978 3604 2165101 SGTC_1581 himbacine 57.9 µM -0.650938172432865 0.293782123835384 no 2371 0.257543199454777 3596 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1125 tnp00248 1.32998 µM -0.651273431450321 0.293686255880187 no 2372 0.25743499792541 3655 24207736 SGTC_2343 7990716 14.84 µM -0.65187137351227 0.293515309159047 no 2373 0.257242076685303 3584 6456862 SGTC_2751 anetholtrithion 17.25 µM -0.653564346209956 0.293031552300146 no 2374 0.256696260451277 3577 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1144 3486-0183 12.5 µM -0.655591469415974 0.292452801001639 no 2375 0.256043507860042 3605 6744069 SGTC_3320 9137005 35.139 µM -0.656920851081138 0.292073546260504 no 2376 0.255615905135584 3570 4908713 SGTC_520 3584-0023 682 µM -0.658429900038845 0.291643312489739 no 2377 0.255130963829519 3552 1340790 SGTC_2681 menadione 3.18 µM -0.660623463916507 0.291018449123218 no 2378 0.254426908833172 3619 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1425 4048-4433 7.33 µM -0.662015459826785 0.290622246816087 no 2379 0.253980656925082 3667 23734946 SGTC_110 0850-0284 111.64 µM -0.663056888410319 0.290325991230964 no 2380 0.253647060138462 3500 3906265 SGTC_1835 st008666 49.2 µM -0.665687824269448 0.289578198531986 no 2381 0.252805328795173 3553 690455 SGTC_1378 2093-0007 380 nM -0.666334732169921 0.289394466067616 no 2382 0.252598585091105 3625 3618014 SGTC_2383 9036125 200 µM -0.667866957532292 0.288959507531523 no 2383 0.252109260484339 3576 79580 SGTC_482 fipronil 114 µM -0.668209406926671 0.288862337214394 no 2384 0.251999965790113 3643 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1029 k015-0030 64.7 µM -0.668612429467124 0.288747998918235 no 2385 0.251871370861291 3639 2208316 SGTC_1678 st019265 80.2 µM -0.67046783442987 0.288221891906434 no 2386 0.251279802261018 3652 5367020 SGTC_2765 myclobutanil 7.74 µM -0.672536749828664 0.287635776965706 no 2387 0.250621026311125 3647 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2152 5568786 200 µM -0.672884548417786 0.287537302440622 no 2388 0.250510371538228 3605 5399883 SGTC_2650 prasterone 100 µM -0.673294994885998 0.287421110514462 no 2389 0.250379818175015 3594 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1886 st057356 49.9 µM -0.673500811980779 0.287362854798575 no 2390 0.250314366179397 3592 24207747 SGTC_2682 pyrogallin 40.03 µM -0.675401055881674 0.28682526230813 no 2391 0.249710497425501 3664 822798 An ATP competetive kinase inhibitor. SGTC_2851 9015922 71.43 µM -0.677942927906907 0.286106894796625 no 2392 0.248903940131856 3632 2996893 SGTC_2580 diallyl disulphide 81.36 µM -0.679070387521997 0.285788533302902 no 2393 0.248546632169859 3648 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1339 1486-1321 22.7 µM -0.67938707779043 0.285699139587363 no 2394 0.248446317709671 3661 3469382 SGTC_497 capsazepine 133 µM -0.681746535603892 0.285033542969135 no 2395 0.24769961816769 3628 2733484 A calcium channel blocker. SGTC_2189 6047310 154.431 µM -0.682598555211405 0.284793372392133 no 2396 0.247430273648713 3595 711535 SGTC_3177 9107506 49.47 µM -0.684404402089032 0.284284652784802 no 2397 0.246859918517662 3594 8897194 SGTC_3193 9111931 49.47 µM -0.684898652620832 0.284145494726508 no 2398 0.246703938151334 3689 17087244 SGTC_2401 5128683 200 µM -0.68506344128622 0.284099105112861 no 2399 0.246651944283468 3611 708373 SGTC_1347 1493-0251 600 nM -0.685136879033223 0.284078432839049 no 2400 0.246628775208366 3678 3986378 SGTC_220 paclitaxel 373.376 µM -0.685936143303757 0.283853491407725 no 2401 0.246376688542311 3614 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.686975310979946 0.283561160167024 no 2402 0.246049143339076 3609 4620898 SGTC_1717 st033143 58.0435 µM -0.689051336708248 0.282977579755979 no 2403 0.245395481048549 3669 674616 SGTC_348 k064-0012 10.7 µM -0.689636447257249 0.282813206697666 no 2404 0.245211420502034 3597 5066323 SGTC_738 1315-0003 72.4 µM -0.690820510851861 0.282480712240978 no 2405 0.244839172134844 3663 6251474 SGTC_1578 josamycin 24.2 µM -0.69153533877293 0.282280073924033 no 2406 0.244614590372658 3598 5282165 A P450 substrate. SGTC_1161 k007-0610 110 µM -0.692097702374602 0.282122277590942 no 2407 0.244437987239492 3702 5843850 SGTC_1210 3013-0140 750 nM -0.693485904960649 0.281732936994491 no 2408 0.244002334146136 3679 905973 SGTC_3167 9103034 49.47 µM -0.695838113376637 0.281073819513657 no 2409 0.243265108796672 3676 5127859 SGTC_154 3389-1638 511.116 µM -0.696529477127558 0.280880232713924 no 2410 0.243048651861102 3591 5238686 SGTC_690 glyoxal 20.3 µM -0.696574475411589 0.280867635106633 no 2411 0.243034567099221 3577 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1229 0139-0193 12.2 µM -0.696825678868402 0.280797313832831 no 2412 0.242955946860027 3704 3090752 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.696833407099447 0.280795150545959 no 2413 0.242953528340096 3735 6710655 SGTC_1624 st003710 6.25 µM -0.696922242213745 0.280770284394474 no 2414 0.242925728670975 3678 24207033 SGTC_3207 9114163 49.47 µM -0.69698289729821 0.280753306826732 no 2415 0.242906748524903 3703 849233 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.697159893636178 0.280703767778455 no 2416 0.242851367543223 3675 688664 SGTC_217 ketoconazole 989 nM -0.69761260547652 0.280577078670272 no 2417 0.242709748100257 3608 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2351 9026858 72.31 µM -0.697681136350072 0.280557903064979 no 2418 0.242688313847448 3618 1409300 SGTC_2122 5258151 111.688 µM -0.697904558138281 0.280495391878977 no 2419 0.242618441815862 3670 2173356 SGTC_2789 5281112 71.43 µM -0.699866781664489 0.279946671119151 no 2420 0.242005252111834 3689 765948 SGTC_1307 1187-1599 12.2 µM -0.701559823029336 0.279473643761767 no 2421 0.24147685735247 3673 1538471 SGTC_1005 4092-0690 4.4 µM -0.702992111797767 0.27907377271142 no 2422 0.241030332688433 3680 1529343 SGTC_474 dl-dihydrosphingosine 5 µM -0.703402943804173 0.278959126658119 no 2423 0.240902336246122 3704 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3076 9116187 49.47 µM -0.70349964358196 0.278932145120387 no 2424 0.240872214399503 3642 27241210 SGTC_2772 vinpocetine 57.06 µM -0.705392977015346 0.278404116001758 no 2425 0.240282856660859 3700 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.705426878446635 0.278394665719793 no 2426 0.240272310972204 3693 688669 SGTC_2159 5658611 73.75 µM -0.706678260662387 0.278045942832926 no 2427 0.239883221115684 3690 793844 SGTC_1117 retinoic acid 1.10837 µM -0.706950455694136 0.277970118427917 no 2428 0.239798633570593 3694 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3036 9090181 49.47 µM -0.707181926860983 0.277905646265669 no 2429 0.23972671421121 3704 25236586 SGTC_503 tyrphostin 8 294 µM -0.709117530042788 0.277366804436938 no 2430 0.23912577267711 3654 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1736 st036774 51 µM -0.709288716343797 0.277319173431202 no 2431 0.239072664581611 3736 1272247 SGTC_2586 curcumin 80 µM -0.709371717819848 0.277296080477757 no 2432 0.239046916884781 3707 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_341 1486-1430 230 µM -0.709464603921001 0.277270238505418 no 2433 0.239018104698658 3663 2054753 YPL210C SRP72 SGTC_1027 k015-0025 8.67 µM -0.710080774070167 0.277098842774282 no 2434 0.238827023976952 3668 3598955 SGTC_2229 7354935 190 µM -0.710922821657889 0.276864700173264 no 2435 0.238566031500798 3631 318112 SGTC_2870 9038528 12.99 µM -0.711131095774263 0.276806801717977 no 2436 0.238501501071982 3668 6463316 SGTC_2415 st077333 57.7 µM -0.712106816282892 0.276535638611036 no 2437 0.238199316843576 3721 2766255 SGTC_2125 5246583 200 µM -0.712710795738842 0.276367851577339 no 2438 0.238012367350495 3713 835267 SGTC_1092 toremifene 6.32 µM -0.713214524118826 0.276227952750181 no 2439 0.237856510060853 3695 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1489 4065-0444 182 µM -0.713428124083444 0.276168640828484 no 2440 0.237790437552422 3668 2877968 SGTC_2131 toluylene red 5.2905 µM -0.714107698384405 0.275979979870099 no 2441 0.237580292983786 3703 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2945 9067681 61.76 µM -0.714234043643633 0.275944911335572 no 2442 0.237541234513475 3772 16456930 SGTC_1995 st072814 61.1 µM -0.714818994407699 0.275782580263197 no 2443 0.237360448322747 3672 5769371 SGTC_2295 7971645 200 µM -0.71791343681719 0.274924615825179 no 2444 0.236405331170439 3723 2978226 YKL099C UTP11 SGTC_3307 9126885 69.2785 µM -0.718574082771049 0.274741615792245 no 2445 0.236201693460547 3709 24824909 SGTC_484 loperamide 105 µM -0.719327228881981 0.27453306635043 no 2446 0.23596966137079 3675 3955 An opioid-receptor agonist. SGTC_2776 terbinafine 19.92 µM -0.719805720265608 0.274400610586041 no 2447 0.235822311223288 3719 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2694 st077685 81.9 µM -0.721849729631922 0.273835144284371 no 2448 0.235193435529334 3694 2838096 SGTC_2626 ethyl orsellinate 100 µM -0.722611965608586 0.273624422612537 no 2449 0.234959157412054 3706 75653 A natural product. SGTC_1667 st014849 34.6 µM -0.723104051097053 0.273488427219045 no 2450 0.234807980301009 3763 5348460 SGTC_378 3970-0959 8.33 µM -0.723603257940746 0.273350497926371 no 2451 0.234654670344235 3726 6615653 SGTC_1751 st044839 27.194 µM -0.724998938617031 0.272965058596465 no 2452 0.234226340782657 3700 5291326 SGTC_2840 9008771 71.43 µM -0.726241698779297 0.27262207764397 no 2453 0.23384530658259 3685 2992978 SGTC_1237 0330-0133 46.1 µM -0.727896389845784 0.272165742934937 no 2454 0.233338506648177 3661 X1237 YHR072W ERG7 SGTC_2280 7785178 200 µM -0.730832701213989 0.271356895688079 no 2455 0.232440673349841 3728 2954328 SGTC_19 0279-0214 38.434 µM -0.732015567331938 0.271031397791574 no 2456 0.232079533061387 3784 3566274 YBR002C RER2 SGTC_2756 carbadox 75.1 µM -0.73329000159499 0.270680920515914 no 2457 0.231690785951915 3740 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1053 3366-3204 134 µM -0.733996293824738 0.27048678331522 no 2458 0.2314754984403 3742 3632071 YPR165W RHO1 SGTC_319 1348-1596 45.5 µM -0.734323061581127 0.270396988829722 no 2459 0.231375932918099 3790 5380505 SGTC_894 0960-0238 55.9 µM -0.737302582564581 0.269578916164065 no 2460 0.230469181025517 3711 6741907 YDL195W SEC31 SGTC_268 camptothecin 39.6153 µM -0.73811036941127 0.269357339916685 no 2461 0.230223691506934 3729 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_546 peri-Naphthalide 147 µM -0.738728996327024 0.269187712078977 no 2462 0.230035787352576 3694 223824 A penicillin ester. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.73954599053172 0.2689637739733 no 2463 0.229787761908367 3720 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1279 0874-0590 65.2 µM -0.741070114252804 0.268546261796285 no 2464 0.22932546454319 3779 3523074 SGTC_2771 fluoxetine 41.05 µM -0.741917034617347 0.268314400808328 no 2465 0.229068802102166 3722 3386 A selective serotonin reuptake inhibitor. SGTC_2729 fluphenazine 10.66 µM -0.74298662994029 0.268021722162802 no 2466 0.228744887555277 3689 3372 An atypical antipsychotic. SGTC_3077 9117319 49.47 µM -0.743650950610444 0.26784002177208 no 2467 0.228543835266689 3722 17154678 SGTC_2846 9008642 19.48 µM -0.744016737802196 0.26774000068792 no 2468 0.228433174563559 3780 2992898 SGTC_2447 5741742 33.78 µM -0.746061175637188 0.267181315090254 no 2469 0.227815230464255 3794 1776504 SGTC_1785 bathophenanthroline 24 µM -0.747965466508226 0.266661457435078 no 2470 0.227240493822711 3701 72812 An iron chelator. SGTC_175 3793-3120 23.7 µM -0.749640211772007 0.26620468706764 no 2471 0.226735712697008 3763 5322297 SGTC_954 1189-0853 2.85 µM -0.750074355739526 0.266086343234326 no 2472 0.226604961704756 3725 2828194 SGTC_2678 equilin 100 µM -0.752539404518522 0.265414898096249 no 2473 0.225863371194856 3759 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2445 5742597 35.57 µM -0.756826752390501 0.264249135633932 no 2474 0.224576831518544 3726 1774255 SGTC_2248 tofa 1.1 µM -0.756890804976563 0.264231739038094 no 2475 0.224557642306192 3700 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3331 9141060 1.957 µM -0.75753266068468 0.26405744410704 no 2476 0.224365403154238 3757 4906567 YPR165W RHO1 SGTC_3287 9117173 37.0625 µM -0.758275257635312 0.263855866165525 no 2477 0.22414310807462 3760 2789709 SGTC_1238 0333-0287 48.8 µM -0.759296019457085 0.263578908467394 no 2478 0.223837749073482 3771 7226 SGTC_169 k015-0017 16.025 µM -0.760583809963478 0.263229711085809 no 2479 0.223452846462525 3780 1840002 SGTC_1679 SEC14.276 6.7 µM -0.763103014117842 0.262547287416956 no 2480 0.222700981315223 3822 1005053 YMR079W SEC14 SGTC_1391 3442-0225 151 µM -0.763592283267703 0.262414855073419 no 2481 0.222555124650206 3727 5227075 SGTC_2452 5863136 48.41 µM -0.765294307610211 0.261954428262641 no 2482 0.222048156464273 3750 2184096 SGTC_1976 st070609 63.5 µM -0.766899535754906 0.261520566342918 no 2483 0.221570624858693 3709 682556 SGTC_1838 st055369 84.5 µM -0.767105409910247 0.261464949268972 no 2484 0.221509422841165 3762 676036 SGTC_477 mead ethanolamide 10 µM -0.767487617989649 0.261361711545236 no 2485 0.221395826117497 3657 16061185 SGTC_35 0133-0054 64.071 µM -0.767543764600265 0.261346547621683 no 2486 0.221379141492861 3774 99677 SGTC_419 nsc-638432 893 µM -0.769323824661511 0.260866028236654 no 2487 0.220850548603972 3763 368090 SGTC_2721 ifenprodil 61.44 µM -0.769882119503909 0.260715412671702 no 2488 0.220684910666222 3769 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1201 1889-3372 45.9 µM -0.769912490443239 0.26070722054952 no 2489 0.220675902092634 3694 5392199 SGTC_292 k038-0015 474 µM -0.770135190812608 0.260647154388931 no 2490 0.220609851543738 3769 46368540 SGTC_3216 9129716 49.47 µM -0.771454132394843 0.260291558992076 no 2491 0.220218899815763 3783 8056934 SGTC_3346 9158254 43.5805 µM -0.772130560589393 0.260109286483186 no 2492 0.220018551777509 3806 17639500 SGTC_1843 st055809 45.5 µM -0.772631383763478 0.259974375472564 no 2493 0.219870282750705 3823 16413835 SGTC_1370 2001-0092 44.6 µM -0.772685709985043 0.259959743324716 no 2494 0.219854202885774 3848 790957 SGTC_1226 3909-7979 35.4 µM -0.773105354138695 0.25984673127441 no 2495 0.219730016343165 3805 6615510 SGTC_1868 st057644 42.7 µM -0.77327948912127 0.259799843385852 no 2496 0.219678495885436 3794 688665 SGTC_1041 0206-0046 107 µM -0.773549291939301 0.259727204432342 no 2497 0.219598684358293 3820 50494 SGTC_2100 5377183 190 µM -0.77518971295558 0.259285779954287 no 2498 0.2191137829619 3813 2844202 SGTC_779 1360-0071 233 µM -0.775199833028121 0.259283057925585 no 2499 0.219110793423989 3872 7566 SGTC_3204 9114183 49.47 µM -0.775423133977864 0.259222999703623 no 2500 0.219044834780633 3819 17027248 SGTC_2712 st079126 47.7 µM -0.775592040855414 0.25917757589287 no 2501 0.218994950646454 3787 3152970 SGTC_2023 5144124 124 µM -0.776038332585445 0.259057575293869 no 2502 0.218863176466069 3794 2830192 SGTC_250 brefeldin a 552.239 µM -0.777111034390422 0.258769260763594 no 2503 0.21854663219003 3677 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2604 4'-hydroxychalcone 11.32 µM -0.778419642795463 0.25841776563153 no 2504 0.218160831247706 3818 5282362 SGTC_2075 5212009 200 µM -0.779829165987513 0.258039441449986 no 2505 0.21774571824451 3682 780898 SGTC_916 4466-0038 42 nM -0.781107218771024 0.257696653170796 no 2506 0.217369718269747 3885 5722064 YGL116W CDC20 SGTC_1291 0993-0025 5.79 µM -0.781822964016591 0.257504785484678 no 2507 0.217159311655833 3840 4353356 SGTC_709 3807-1509 243 µM -0.782177077431904 0.257409886806638 no 2508 0.217055256958933 3864 1886677 YPL242C IQG1 SGTC_2716 st080858 38.6235 µM -0.783572465547132 0.257036114399228 no 2509 0.216645508746173 3798 5296050 SGTC_424 splitomicin 100 mM -0.783610494391095 0.257025931844089 no 2510 0.216634348047205 3896 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_895 0964-0006 13.7 µM -0.7836353967097 0.257019264144458 no 2511 0.216627039898971 3767 6738897 SGTC_2290 7904846 200 µM -0.783717373866001 0.256997315054712 no 2512 0.216602982857099 3875 2962154 SGTC_2118 5526350 200 µM -0.785640128373582 0.25648278420872 no 2513 0.216039174098981 3856 743594 SGTC_2089 5281248 129.67 µM -0.786766367816685 0.25618165094858 no 2514 0.21570932241586 3807 2737878 SGTC_3041 9091929 49.47 µM -0.787598106739413 0.255959379474798 no 2515 0.215465911235094 3830 25236887 SGTC_374 0880-0231 82.3 µM -0.787836219149795 0.255895765543126 no 2516 0.21539625618696 3758 6833587 SGTC_492 tmb-8 126 µM -0.787917603732193 0.255874024791635 no 2517 0.215372451742564 3713 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_901 1112-0062 60.1 µM -0.789225559114834 0.255524755108387 no 2518 0.214990092997684 3806 1908457 SGTC_2804 7954240 19.48 µM -0.789379036925535 0.255483787516157 no 2519 0.214945252199064 3852 828705 SGTC_1927 st060202 13.8 µM -0.790035808393187 0.255308515305573 no 2520 0.214753428125384 3741 688887 SGTC_1018 4259-0013 28.1 µM -0.793755105919383 0.254317135696428 no 2521 0.213669006416459 3912 6801262 SGTC_666 0272-0154 136 µM -0.795534093418077 0.253843660631757 no 2522 0.213151443518972 3855 6870312 SGTC_1627 st003713 25.6 µM -0.796025824047535 0.253712868877886 no 2523 0.213008512853306 3891 16195070 YER133W GLC7 SGTC_75 0159-0059 199.013 µM -0.797842002060122 0.253230104157748 no 2524 0.212481091814506 3859 5377270 SGTC_618 k072-0232 33.2 µM -0.797926375972331 0.253207688176144 no 2525 0.212456608052221 3867 5872756 YGL099W LSG1 SGTC_1594 piperine 70.1 µM -0.798146731255793 0.253149150357994 no 2526 0.212392672763111 3800 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2215 7188065 200 µM -0.799204097842562 0.252868357879054 no 2527 0.212086038109692 3827 940217 SGTC_2838 9002687 71.43 µM -0.799333567557641 0.252833987390385 no 2528 0.212048509891824 3829 6457060 SGTC_1763 st044482 94.5 µM -0.80024982001023 0.25259081900055 no 2529 0.211783035068857 3871 88505 SGTC_550 4123-0385 25.7 µM -0.800509219020975 0.252521998305582 no 2530 0.211707912184081 3855 5731123 SGTC_3251 9135047 49.47 µM -0.801083966543546 0.252369548255176 no 2531 0.211541518807476 3842 17682963 SGTC_695 3505-6186 243 µM -0.801394134348512 0.252287297337797 no 2532 0.211451754905257 3827 1819379 SGTC_1600 coumarin 106 71.1 µM -0.803539071899706 0.251718885565942 no 2533 0.210831611474476 3927 100336 A hepatotoxic, DNA x-linker. SGTC_2825 7998094 58.44 µM -0.804570078706633 0.251445908023861 no 2534 0.21053390719074 3847 2987815 SGTC_2601 securinine 100 µM -0.804782194630869 0.251389765939952 no 2535 0.210472689111315 3796 442872 A GABA receptor antagonist. SGTC_1819 st053448 58.6 µM -0.806703876844799 0.250881444038938 no 2536 0.209918555004502 3769 2857616 SGTC_1310 1188-0297 994 nM -0.809119051805508 0.250243356223782 no 2537 0.209223335293699 3758 1588352 SGTC_39 0986-0283 58.349 µM -0.809148126928553 0.250235679839114 no 2538 0.209214974145061 3923 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_409 arachidonic acid 100 µM -0.810936343288231 0.249763796867673 no 2539 0.208701113985876 3846 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2982 9019404 25.97 µM -0.811171966778595 0.249701654678999 no 2540 0.208633460952285 3804 22333232 SGTC_2553 4-methylesculetin 85.09 µM -0.811743863301652 0.249550859640287 no 2541 0.208469309817098 3902 5319502 SGTC_2807 7945238 51.95 µM -0.813212361645278 0.24916387449551 no 2542 0.208048156594205 3911 17148797 SGTC_269 exalamide 29 µM -0.81871114256274 0.24771765135184 no 2543 0.206475618913507 3805 3316 A derivative of salicylamide. SGTC_1335 1486-0900 202 µM -0.820355749710416 0.247285979041274 no 2544 0.206006666774695 3848 X1335 SGTC_1850 st056238 17 µM -0.820388930304982 0.247277274023753 no 2545 0.205997211986669 3867 5393177 SGTC_1207 2099-0101 141 µM -0.821137982676229 0.247080801740111 no 2546 0.205783838511243 3894 5837381 SGTC_1999 st074831 12.5 µM -0.82143533148572 0.247002831956739 no 2547 0.205699172734155 3845 17112523 SGTC_2405 ticlatone 3.52 µM -0.822781454060227 0.246650021081173 no 2548 0.205316142506517 3754 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2998 9066762 71.4286 µM -0.823765079212423 0.2463923894285 no 2549 0.20503652659983 3871 4945196 SGTC_1196 1588-0294 184 µM -0.826034677145028 0.245798485800011 no 2550 0.204392210485592 3885 6144269 SGTC_1214 0358-0031 63.7 µM -0.829073993433834 0.245004369045043 no 2551 0.203531269361991 4027 4301366 SGTC_1349 flufenamic acid 69 µM -0.831210493154028 0.244446968680262 no 2552 0.202927364024441 3820 3371 A non-steroidal anti-inflammatory. SGTC_1782 st039423 80.636 µM -0.831551054782298 0.244358181309998 no 2553 0.202831199495053 3909 2068169 SGTC_2308 7584454 197.62 µM -0.832949430096926 0.243993795003016 no 2554 0.202436625156119 3893 893577 SGTC_1233 0325-0408 14.2 µM -0.837253126638295 0.242874186623011 no 2555 0.201225150338572 3946 12874 SGTC_905 2-aminofluorene 215 µM -0.838975629919396 0.242426856907444 no 2556 0.200741492610956 3891 1539 An established DNA mutagen. YPR165W RHO1 SGTC_577 r071-0003 38.6 µM -0.839213244732117 0.242365183997904 no 2557 0.200674828105621 3918 4568517 YMR134W ERG29 SGTC_2394 5221648 200 µM -0.839784459174685 0.242216960114399 no 2558 0.200514624266824 3964 788586 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.840256864641052 0.242094413208995 no 2559 0.20038219061705 3935 6708561 SGTC_2877 9040724 71.43 µM -0.840676039343373 0.241985703075562 no 2560 0.200264723631525 3828 6463895 SGTC_2587 piperic acid 92.2 µM -0.841027404606105 0.241894599265861 no 2561 0.200166291039099 3910 5370536 SGTC_2112 5488546 200 µM -0.841988826423059 0.241645411971721 no 2562 0.199897103919567 3856 600757 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.842039810604736 0.24163220146618 no 2563 0.199882835012601 3894 91467 include heat shock SGTC_194 1486-1323 56.904 µM -0.842632691005837 0.24147860908681 no 2564 0.199716950974763 3928 5178754 SGTC_817 1391-0715 46 µM -0.843450473979377 0.24126684019286 no 2565 0.199488276635595 3911 1353946 SGTC_2052 5265182 7.135 µM -0.847074931117464 0.240329485372898 no 2566 0.198476678579266 3914 1239884 SGTC_1386 3228-0095 33.8 µM -0.847167724664297 0.240305513240162 no 2567 0.198450820288034 3917 870181 SGTC_734 2023-0417 80 µM -0.847532277819413 0.24021134778991 no 2568 0.198349251851385 3913 3935732 SGTC_192 3455-0609 60.9 µM -0.848334389187965 0.240004230225465 no 2569 0.198125885455958 3966 3769639 SGTC_1286 0929-0070 131 µM -0.84854071227774 0.239950970161372 no 2570 0.198068454603129 4001 1420408 SGTC_2378 9074213 121.43 µM -0.848726529008593 0.239903009108037 no 2571 0.198016740381408 3870 657714 SGTC_660 4031-1742 102 µM -0.849199702817788 0.239780902091526 no 2572 0.197885089305237 3829 6738706 SGTC_761 k216-0224 480 µM -0.851380148481555 0.239218655686727 no 2573 0.197279107778968 3909 1340404 SGTC_2995 9067767 71.4286 µM -0.851566290209803 0.239170690859882 no 2574 0.197227428003844 3947 11673567 SGTC_1426 4048-4480 71.7 µM -0.852276279496003 0.238987789746192 no 2575 0.19703038413207 3872 14224343 SGTC_3142 9086498 49.47 µM -0.85491007380332 0.238309963635485 no 2576 0.196300466627276 3851 25236367 SGTC_2916 7875993 68.79 µM -0.856047891725238 0.23801746395653 no 2577 0.195985644781167 3820 1299250 SGTC_1281 0884-0031 11.8 µM -0.85706222494634 0.23775687458208 no 2578 0.195705248211329 3919 1548255 SGTC_2607 solasodine 47.35 µM -0.858299302217407 0.237439272617659 no 2579 0.195363607326584 3936 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3002 9075603 71.4286 µM -0.861219393747922 0.236690505339946 no 2580 0.194558610329769 3869 20105405 SGTC_1587 estradiol valerate 56.1 µM -0.862389724563995 0.236390775142091 no 2581 0.194236546537157 3967 13791 A steroid. SGTC_1650 st011916 45.8 µM -0.865288956187874 0.235649161676048 no 2582 0.193440105420897 3849 242528 SGTC_2658 polymyxin b sulfate 77.05 µM -0.865544227498555 0.235583925679384 no 2583 0.19337007599873 3939 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3324 9138759 60.749 µM -0.866091888553416 0.235444001485943 no 2584 0.193219886534576 3967 45595710 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.866583121380921 0.235318533402839 no 2585 0.193085232425721 3881 2333 A French combination drug. SGTC_2104 5389443 200 µM -0.866740703300902 0.235278292485441 no 2586 0.193042049055122 3985 2244536 SGTC_2673 kobusone 100 µM -0.866838342161384 0.235253360837808 no 2587 0.193015295295684 3968 6710676 An epoxy ketone and protein crosslinker. SGTC_2097 5376186 200 µM -0.867196179973906 0.235162001018466 no 2588 0.192917264482836 3875 742755 SGTC_555 4296-0685 37 µM -0.868012477946679 0.234953664768077 no 2589 0.19269375087997 3868 2908540 YHR072W ERG7 SGTC_164 4100-3994 89.624 µM -0.868252738784208 0.234892364628531 no 2590 0.19262799431526 3880 4615967 SGTC_2236 dapsone 200 µM -0.868603801089251 0.234802810502534 no 2591 0.192531937355104 3927 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_888 0916-0002 6.97 µM -0.868620278421055 0.234798607686628 no 2592 0.192527429580322 3994 2802138 YIL048W NEO1 SGTC_3262 9137218 49.47 µM -0.87349522920145 0.233556998664682 no 2593 0.191196602743714 3744 17650664 SGTC_2522 biochanin a 4.94 µM -0.873853328915046 0.233465937451702 no 2594 0.19109906693594 3944 5280373 A possible chelator. SGTC_1268 0828-0275 2.46 µM -0.875357697373537 0.233083606669596 no 2595 0.19068965472344 3993 745337 SGTC_3149 9097855 49.47 µM -0.876659834615739 0.232752953232978 no 2596 0.190335714514601 3960 25236625 YMR079W SEC14 SGTC_3274 9138298 49.47 µM -0.877494413549965 0.232541164647597 no 2597 0.190109075921791 3897 17015756 SGTC_302 1094-0063 18.9 µM -0.877625809941362 0.232507830346402 no 2598 0.190073408980885 3898 5440289 SGTC_2064 5220758 200 µM -0.877840964356955 0.232453252986569 no 2599 0.190015015193763 4012 788518 SGTC_3045 9092950 49.47 µM -0.878699055645211 0.23223565529033 no 2600 0.189782235416433 3893 44120432 SGTC_296 1222-0039 74.9 µM -0.887543166744098 0.229999551959093 no 2601 0.187393268246822 3948 5984176 SGTC_1632 st005650 90 µM -0.89117538819914 0.229084700502127 no 2602 0.18641754293808 3991 2759605 SGTC_2347 9049783 174.81 µM -0.891643336044537 0.228966986593751 no 2603 0.18629206712849 4011 6467988 YPL169C MEX67 SGTC_1725 st036284 20.55 µM -0.892399894211658 0.228776743568539 no 2604 0.186089313903106 4064 707914 SGTC_46 0329-0187a 2.197 µM -0.892997221997054 0.228626603094482 no 2605 0.185929330173046 4027 46494817 SGTC_1790 st045711 43.5 µM -0.893551273955993 0.228487389635613 no 2606 0.185781013377851 3941 585119 SGTC_1672 st016598 6.51 µM -0.893782543072534 0.228429294061665 no 2607 0.185719125567604 4005 4665860 YNL267W PIK1 SGTC_2623 humulene 100 µM -0.89691439039861 0.22764338126885 no 2608 0.184882300326459 3971 6187145 An anti-inflammatory. SGTC_2136 5328288 199.296 µM -0.897012194598419 0.227618862600331 no 2609 0.184856204969307 3964 262395 SGTC_1546 5-methoxyflavanone 78.7 µM -0.897136461798835 0.227587712030852 no 2610 0.184823052262028 3951 147795 SGTC_1925 st057770 10.1 µM -0.898568975476216 0.227228791319616 no 2611 0.184441145043951 3953 5989122 SGTC_826 1683-5028 118 µM -0.899730185962247 0.226938080713023 no 2612 0.184131927599162 4028 722377 SGTC_1815 st051655 58.2 µM -0.900448944177616 0.226758243780321 no 2613 0.183940692057201 3925 5984156 SGTC_643 k048-0106 28.4 µM -0.901604119462247 0.226469381634835 no 2614 0.18363360096408 3986 6763920 SGTC_80 0159-0065 512.242 µM -0.903110739954588 0.226092949805187 no 2615 0.183233562252744 3868 1548079 SGTC_739 1486-1183 203 µM -0.903836354457542 0.225911779968357 no 2616 0.183041090746426 3967 4346692 SGTC_2083 5306046 65.942 µM -0.904048275067335 0.225858883587468 no 2617 0.182984901952838 3992 539837 SGTC_1710 st031758 61.5 µM -0.90443984485603 0.225761164356244 no 2618 0.182881109156908 4007 5394341 SGTC_3168 9103419 49.47 µM -0.907153755096432 0.225084544972507 no 2619 0.182162747417637 3966 16649256 SGTC_2314 7727897 200 µM -0.907851757026221 0.224910708346189 no 2620 0.181978274492667 3989 900724 SGTC_3194 9111903 49.47 µM -0.908355739452569 0.224785239394643 no 2621 0.181845151074343 4013 17087251 SGTC_863 0466-0191 129 µM -0.909454165926541 0.224511918178922 no 2622 0.181555220554359 4017 765160 YPR165W RHO1 SGTC_724 3910-0327 137 µM -0.909657150796682 0.224461430150324 no 2623 0.181501674229546 4030 2885483 SGTC_2398 5228213 48.84 µM -0.90975604912188 0.224436833698408 no 2624 0.181475588961249 3991 80771 YMR134W ERG29 SGTC_3135 9127742 49.47 µM -0.91562434855197 0.222980102358048 no 2625 0.179931978057885 4070 3643468 SGTC_704 1310-0270 142 µM -0.915732793335774 0.222953233084664 no 2626 0.179903530310412 4002 5718033 SGTC_698 k064-0052 127 µM -0.916060119051887 0.222872143051082 no 2627 0.179817681815488 4056 5088751 SGTC_2675 theaflavin digallate 100 µM -0.916273068801513 0.222819396969518 no 2628 0.179761844796441 3940 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2683 piperine 63.03 µM -0.91660133032422 0.222738102947392 no 2629 0.179675793506622 3966 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1358 1509-0022 2.48 µM -0.916981806776574 0.222643899042682 no 2630 0.179576086857596 4014 3258434 SGTC_703 3875-0075 71.8 µM -0.917264369778884 0.222573952675949 no 2631 0.17950206165362 4027 2850814 SGTC_324 1315-0088 19.6 µM -0.917923413647911 0.222410859972274 no 2632 0.179329481413186 3957 6787421 SGTC_2231 micatex 6.853 µM -0.918185027136336 0.222346137736965 no 2633 0.17926100304722 4016 20737 An antifungal of unknown mechanism. SGTC_2857 9024691 58.44 µM -0.919003675273391 0.222143676564051 no 2634 0.179046824920242 4083 16478292 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.919146208849147 0.222108437116412 no 2635 0.179009551156903 4003 165521 SGTC_846 0335-0850 148 µM -0.92064988378593 0.22173686881021 no 2636 0.178616624648372 3983 6819598 SGTC_542 3381-0244 89.3 µM -0.922108734406364 0.22137671654731 no 2637 0.178235930727044 4035 1112843 SGTC_2101 5377231 179.231 µM -0.922286476717602 0.221332859466439 no 2638 0.178189583008593 4035 2844213 SGTC_1608 st001473 40.5 µM -0.922419075437118 0.221300144591233 no 2639 0.178155011787837 3978 7292267 SGTC_1826 st055655 41.6 µM -0.92343599814188 0.221049340460846 no 2640 0.177890019630312 4033 676168 SGTC_1887 st057648 70.8 µM -0.923657584286094 0.220994712156567 no 2641 0.177832311183452 4010 688672 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.923832486642503 0.220951598405246 no 2642 0.177786769096965 4033 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2705 st078069 42.8 µM -0.924329958504623 0.220828997005178 no 2643 0.177657274726514 4056 1530061 SGTC_15 0266-0086 27.098 µM -0.924857896740143 0.220698929814587 no 2644 0.177519914921331 4062 1712902 YIL048W NEO1 SGTC_1872 amphotericin b 148 nM -0.926176988962847 0.220374139297654 no 2645 0.177177004497923 4017 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_721 1187-1332 279 µM -0.926344012801347 0.22033303378006 no 2646 0.177133614942373 3935 25730 SGTC_2905 7799065 20.05 µM -0.92814717691715 0.219889544787868 no 2647 0.176665615317666 3922 1296806 SGTC_1764 st044502 93.5 µM -0.928583840912289 0.219782224192861 no 2648 0.176552399689287 4055 8407 SGTC_3074 9116018 49.47 µM -0.932416530524688 0.218841540362366 no 2649 0.175560652553604 4061 17027303 SGTC_3043 9092303 49.47 µM -0.934508952911512 0.218328961599271 no 2650 0.175020709969166 4015 25236084 SGTC_1526 st051518 75 µM -0.9357858389922 0.218016504115125 no 2651 0.174691732003225 4018 673993 SGTC_2785 7756463 72.73 µM -0.937710933506216 0.217545915933026 no 2652 0.174196491741509 3976 2201551 SGTC_3144 9087057 49.47 µM -0.938931821616385 0.217247774629725 no 2653 0.173882874963727 3848 17249618 SGTC_188 3229-0966 278.469 µM -0.939107309286119 0.217204939886698 no 2654 0.173837825937114 4044 5722370 SGTC_3245 9134821 49.47 µM -0.94449054482692 0.215893319347184 no 2655 0.172459515654748 4016 17014901 SGTC_2812 7970281 58.44 µM -0.94551628235225 0.215643920908292 no 2656 0.172197681081115 4086 2233435 SGTC_975 1335-0046 28.5 µM -0.948378355604768 0.214948918663033 no 2657 0.17146843708647 4038 16486740 SGTC_1410 3909-8106 77.9 µM -0.948554662582807 0.214906148310842 no 2658 0.171423579452897 4075 1039210 SGTC_2019 4016004 108 µM -0.948721298439575 0.21486572862251 no 2659 0.17138118932973 4064 45595336 SGTC_1327 1436-0082 2.18 µM -0.949555714675602 0.21466339657392 no 2660 0.171169024839013 4020 15992205 SGTC_1320 1313-0481 95.3 µM -0.949654488452686 0.21463945290886 no 2661 0.171143921052353 4026 6813365 YLR208W SEC13 SGTC_3332 9141069 11.198 µM -0.951243926812668 0.214254372051997 no 2662 0.170740282175691 3969 17332883 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.952767594081939 0.213885603453844 no 2663 0.170353918396446 3969 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2642 cholecalciferol 100 µM -0.954759368267152 0.213404098092413 no 2664 0.169849699680709 4036 9821465 A vitamin D precursor, similar to steriods. SGTC_656 4090-1979 187 µM -0.954961048886713 0.213355377669603 no 2665 0.169798697529492 4109 22330961 SGTC_1407 3909-7909 12.3 µM -0.955120557135045 0.213316849510322 no 2666 0.169758367125194 4013 4411780 SGTC_2471 5466956 24.79 µM -0.95649278380065 0.212985564856531 no 2667 0.169411664207884 4000 724419 SGTC_1967 st070177 51.4 µM -0.95663289222853 0.212951756605882 no 2668 0.169376290393389 4076 5729214 SGTC_334 1502-1024 68.5 µM -0.957419761928561 0.212761942647899 no 2669 0.169177713888967 4072 3296216 SGTC_2377 9073351 62.6 µM -0.958473866964327 0.212507819249628 no 2670 0.168911931525378 4009 7337946 YHR072W ERG7 SGTC_320 4092-0846 5.34 µM -0.95963354873414 0.212228448373061 no 2671 0.168619839074391 4016 1359356 SGTC_934 2950-0684 338 µM -0.961533385145131 0.211771236220482 no 2672 0.168142023792301 4089 1121253 SGTC_2362 9071156 126 µM -0.961885084040545 0.21168666009394 no 2673 0.168053665987076 4085 653133 SGTC_1559 coumarin 343 70.1 µM -0.962039486137565 0.211649535909322 no 2674 0.168014884772577 4082 108770 A hepatotoxic, DNA x-linker. SGTC_3024 9090631 49.47 µM -0.962178389623934 0.211616141441504 no 2675 0.167980001270002 4008 25236383 SGTC_501 nsc-95397 161 µM -0.962329888160095 0.211579722452875 no 2676 0.167941960026921 4109 262093 SGTC_2430 5571206 200 µM -0.965806597338719 0.21074495927032 no 2677 0.167070483326165 4072 1731771 SGTC_2487 5918373 44.05 µM -0.972654080700884 0.209106528974299 no 2678 0.165362627269664 4128 2876279 SGTC_1356 1502-0781 85.8 µM -0.9740955975983 0.208762568443276 no 2679 0.165004537605851 4039 567702 SGTC_2214 7179297 48.276 µM -0.974995279257727 0.208548064375505 no 2680 0.164781300815483 4076 769744 SGTC_147 4466-0538 29.23 µM -0.9772225599605 0.208017590631643 no 2681 0.164229490779061 4156 6742687 YHR072W ERG7 SGTC_1855 st056195 39.6 µM -0.977553275516516 0.207938891740735 no 2682 0.164147658108927 4016 4028379 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.978085097275081 0.207812373384247 no 2683 0.164016118938853 4054 364106 SGTC_1512 0259-0544 12.2 µM -0.978140775565402 0.207799130362116 no 2684 0.164002351596124 4027 18476 SGTC_1465 k213-0056 144 µM -0.978989196045924 0.207597396125518 no 2685 0.163792658898912 3938 24048857 YMR208W ERG12 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.981002021875436 0.207119257157215 no 2686 0.16329587224688 4109 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1208 2323-2347 50.3 µM -0.982107790898042 0.206856863491862 no 2687 0.163023373840004 4087 5412760 SGTC_2815 7968870 71.43 µM -0.982504024365965 0.206762887104428 no 2688 0.162925800663819 4058 2977326 YHR190W ERG9 SGTC_2045 5106652 78.05 µM -0.982846621435189 0.206681652270767 no 2689 0.162841466158009 4036 673349 SGTC_2321 7390090 138.78 µM -0.983799462582705 0.206455818937641 no 2690 0.162607061819607 4100 649046 SGTC_3280 9140961 49.47 µM -0.984905367949572 0.206193891175223 no 2691 0.16233527819784 4109 4901226 SGTC_764 1951-2361 146 µM -0.985482341144771 0.206057316399289 no 2692 0.162193600632255 4067 5438930 SGTC_2997 9067075 71.4286 µM -0.98583018551987 0.205975004413996 no 2693 0.162108225274038 4092 27209819 SGTC_842 0271-0008 11.1 µM -0.987616521550379 0.205552602988227 no 2694 0.161670245879077 4124 1221709 SGTC_1303 1160-0052 261 µM -0.987910413682254 0.205483157828017 no 2695 0.161598262450465 4026 3562476 SGTC_345 1362-0200 395 µM -0.98817966653562 0.205419547029339 no 2696 0.161532332298404 4063 1419823 SGTC_3029 9088683 49.47 µM -0.988703607757022 0.205295799805792 no 2697 0.161404088575755 4119 25236615 SGTC_2845 9003024 42.97 µM -0.988961837562025 0.205234826012446 no 2698 0.161340906775087 4155 2990173 SGTC_307 1501-1223 22.3 µM -0.991593602967033 0.204614021573613 no 2699 0.160697905545681 4106 2830329 SGTC_3022 9087993 49.47 µM -0.992713742079718 0.204350132436216 no 2700 0.160424738041527 4137 17173644 SGTC_1134 3477-0009 42.5 µM -0.993852528634017 0.204082058032047 no 2701 0.160147334209738 4194 3973534 SGTC_2372 9071633 200 µM -0.99436601977459 0.203961248950967 no 2702 0.160022352473275 4104 21321366 SGTC_655 k060-0012 42 µM -0.994445087729223 0.203942650416842 no 2703 0.16000311331045 4061 5994525 SGTC_2213 7173844 200 µM -0.996830643547617 0.203381990194823 no 2704 0.159423360682689 4042 892728 SGTC_1345 1488-0192 31.4 µM -0.998904238413757 0.202895395844207 no 2705 0.158920541422684 4139 658348 SGTC_708 3448-5400 146 µM -1.00039746265191 0.20254542361439 no 2706 0.158559098718455 4034 3462195 SGTC_1761 st044296 37 µM -1.00169862184833 0.202240760769102 no 2707 0.15824458625299 4075 1826700 SGTC_337 1315-0038 354 µM -1.002368478139 0.20208402271196 no 2708 0.158082830249741 4044 1626437 SGTC_672 1441-0018 53.7 µM -1.00275376097536 0.201993904249106 no 2709 0.157989841848078 4085 251141 SGTC_2237 6667747 47.222 µM -1.00388731068459 0.201728904123767 no 2710 0.157716466776189 4093 729940 YDL015C TSC13 SGTC_897 1000-0139 31.4 µM -1.00484445465968 0.201505306168143 no 2711 0.157485877090586 4043 6151020 SGTC_1943 st076331 65.2 µM -1.00527320609445 0.201405193925751 no 2712 0.157382656620647 4105 24208415 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.00565555718147 0.201315941182904 no 2713 0.157290644398469 4068 15053 SGTC_1317 1273-0028 910 nM -1.00584760998211 0.201271118979257 no 2714 0.157244440522944 4074 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1284 0929-0043 16 µM -1.00988093655082 0.200331184720312 no 2715 0.156276168516136 4068 1239883 SGTC_2352 9027995 87.8 µM -1.0098819229728 0.200330955165656 no 2716 0.15627593218937 4049 2997347 SGTC_3175 9106517 49.47 µM -1.01007813937961 0.200285295913295 no 2717 0.156228927385727 4121 41468073 SGTC_747 3448-8087 38.7 µM -1.01195035376602 0.199849949086359 no 2718 0.155780895797315 4140 5168703 SGTC_622 1348-1566 26.3 µM -1.01273182155784 0.199668402527155 no 2719 0.155594136956311 4129 7340407 SGTC_1757 st041620 31.8375 µM -1.01293273843022 0.199621742598265 no 2720 0.155546144775138 4174 5289815 SGTC_537 1334-0398 209 µM -1.01302441109055 0.199600455178491 no 2721 0.155524250551032 4149 5846986 SGTC_3277 9138724 49.47 µM -1.01409616029682 0.199351684351304 no 2722 0.155268435019031 4054 15943418 SGTC_2123 5259487 200 µM -1.01558764567454 0.199005796616655 no 2723 0.15491289520917 4116 2173474 SGTC_880 0833-0487 87.2 µM -1.01561309891651 0.198999896940506 no 2724 0.154906832343751 4100 76075 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.01687157914285 0.198708331720631 no 2725 0.154607262579698 4112 229346 A bile salt which induces apoptosis. SGTC_929 2805-0021 398 µM -1.01733415812043 0.19860122600625 no 2726 0.154497246157307 4177 3098024 SGTC_1723 st034307 2.5525 µM -1.01796206967505 0.198455894846906 no 2727 0.154347991053883 4137 867466 SGTC_2418 pentamidine 31.67 µM -1.02516575726307 0.196793184194701 no 2728 0.152642491252686 4072 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1500 4488-1866 171 µM -1.02668107652381 0.196444504490839 no 2729 0.152285331391473 4180 2900003 SGTC_1640 st009078 66.4 µM -1.02742456220026 0.196273563112989 no 2730 0.152110295294362 4081 690618 SGTC_200 k038-0079 37.545 µM -1.02775531928718 0.196197544813894 no 2731 0.152032469326434 4082 3436683 SGTC_2368 9071271 200 µM -1.02978980660855 0.195730348903929 no 2732 0.151554343410945 4134 27209959 SGTC_258 haloperidol 50.781 µM -1.02988144685505 0.195709320713047 no 2733 0.151532830542136 4122 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_336 4111-0029 111 µM -1.03203628507311 0.195215256994067 no 2734 0.151027559847727 4123 3131175 SGTC_1623 st003709 20.3 µM -1.03283727243531 0.195031799117723 no 2735 0.150840028918645 4089 16192618 SGTC_1411 3909-8223 150 µM -1.03399001150689 0.194767960184437 no 2736 0.150570416407687 4146 X1411 SGTC_17 0960-0276 49.807 µM -1.03407255818168 0.194749075234402 no 2737 0.150551122005606 4108 6821114 SGTC_3107 9121808 49.47 µM -1.03412353897816 0.194737412452522 no 2738 0.150539206612508 4011 662681 SGTC_795 0685-0265 78 µM -1.03427833491946 0.194702002677003 no 2739 0.150503031064555 4143 302754 SGTC_1626 st003712 1.76 µM -1.03510699741114 0.194512511661297 no 2740 0.15030947253263 4161 24207035 SGTC_2745 rifampicin 24.3 µM -1.03784681834704 0.193886793780989 no 2741 0.149670688036889 4158 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2436 5633522 8.09 µM -1.0388810402548 0.193650918395251 no 2742 0.149430032575823 4129 5724242 SGTC_983 1491-0821 12.2 µM -1.04088424637007 0.193194544390379 no 2743 0.148964636993727 4127 46495113 SGTC_2228 7354201 200 µM -1.04135185392973 0.193088107783967 no 2744 0.148856139457321 4181 753451 SGTC_1915 st067105 30.6 µM -1.04205805152302 0.192927431308438 no 2745 0.148692382732741 4078 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3203 9113543 49.47 µM -1.04595842164624 0.192041477717718 no 2746 0.147790114676492 4216 17018012 SGTC_507 nimesulide 162 µM -1.04674431953917 0.191863265961012 no 2747 0.14760875853136 4202 4495 A COX2 inhibitor. SGTC_873 0591-4978 488 µM -1.04998757109889 0.191128891427634 no 2748 0.146861913576933 4229 3305145 SGTC_1371 2421-0008 32.7 µM -1.05314949879925 0.190414592885456 no 2749 0.146136239872136 4120 2827552 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.05380635226111 0.190266411642591 no 2750 0.145985792317199 4094 279621 SGTC_689 0833-0039 98 µM -1.0552511349082 0.189940728810623 no 2751 0.145655241563798 4099 5374726 SGTC_1141 3253-0389 52.6 µM -1.05959045056452 0.188964622662376 no 2752 0.144665479945228 4156 5402031 SGTC_1114 scopoletin 1.73284 µM -1.05996369747414 0.188880807321514 no 2753 0.144580557545006 4188 5280460 A coumarin with genotoxic properties. SGTC_33 0986-0033 35.816 µM -1.06076557600252 0.188700817080898 no 2754 0.144398225030261 4106 2848082 SGTC_1861 st057647 17.4 µM -1.06145199725134 0.188546826481887 no 2755 0.144242268542249 4238 688668 SGTC_2171 5739187 198.077 µM -1.06259994163613 0.188289471759683 no 2756 0.143981706753924 4091 2262761 SGTC_962 1254-0300 21.5 µM -1.06276003946018 0.188253597064781 no 2757 0.143945392798495 4130 7340576 SGTC_2336 9001819 198.65 µM -1.0630191677268 0.18819554058188 no 2758 0.143886629499724 4225 2989602 SGTC_3348 9149464 3.537 µM -1.06335171802316 0.188121050424177 no 2759 0.143811239778658 4104 1951442 SGTC_713 1488-1073 324 µM -1.0682211655975 0.187032395368234 no 2760 0.142710379740133 4112 3312542 SGTC_551 k048-0028 34.9 µM -1.06829734609607 0.187015394830795 no 2761 0.142693202623776 4156 6836383 SGTC_2740 felodipine 17.08 µM -1.06856765536702 0.186955079982775 no 2762 0.142632264790716 4181 3333 L-type calcium channel blocker SGTC_115 0527-0192 112.043 µM -1.07344418017969 0.185869035635015 no 2763 0.141535935476925 4158 4233931 SGTC_3103 9120822 49.47 µM -1.07447983302543 0.185638891466082 no 2764 0.141303839366833 4198 17141819 SGTC_1810 st050138 53 µM -1.07453556921258 0.185626510711485 no 2765 0.141291355867957 4169 3444541 SGTC_2714 st079313 56.9 µM -1.07472078273239 0.185585372662101 no 2766 0.141249878085167 4148 2939799 SGTC_2948 9070189 9.45 µM -1.07543345373665 0.185427133020975 no 2767 0.141090355429436 4112 6473636 YDL196W YDL196W SGTC_382 3229-0966 23.2 µM -1.07614838121453 0.185268476537294 no 2768 0.14093045048697 4203 5722370 SGTC_2939 9044578 71.43 µM -1.07746378378784 0.184976783117173 no 2769 0.14063656098713 4104 2653634 SGTC_1108 betulinic acid 729.144 nM -1.0775739764065 0.184952360621377 no 2770 0.140611960458998 4164 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3080 9117754 49.47 µM -1.07773411970357 0.184916870899547 no 2771 0.140576213637199 4196 9550191 SGTC_2382 9035899 200 µM -1.07953362280861 0.184518369905769 no 2772 0.140174956754373 4161 6462679 SGTC_1139 k015-0024 46.9 µM -1.07955750742935 0.18451308423709 no 2773 0.14016963614989 4192 2766652 SGTC_644 1498-1197 63.3 µM -1.08108902648739 0.184174355571509 no 2774 0.139828757116761 4205 6741615 SGTC_995 3931-2021 34.6 µM -1.08142012800173 0.184101176202088 no 2775 0.139755136084057 4175 730143 SGTC_2157 5649910 96.377 µM -1.0842749957369 0.183470950357883 no 2776 0.139121444169051 4166 2858091 SGTC_1331 1472-0049 76.2 µM -1.08556045589118 0.183187618435004 no 2777 0.138836751491796 4119 24051409 SGTC_410 α-linolenic acid 100 µM -1.08809300872779 0.182630210261579 no 2778 0.138277024896676 4234 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2247 cerulenin 830 nM -1.08943556975517 0.182335146154037 no 2779 0.1379809264689 4238 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_809 3998-0021 90 µM -1.09410434851927 0.181311376558458 no 2780 0.136954607740296 4144 715485 SGTC_621 3584-0052 32.1 µM -1.09420362592723 0.181289646169594 no 2781 0.136932840784619 4198 2273927 SGTC_1107 amlodipine 47 µM -1.09711300703983 0.180653549090878 no 2782 0.136295997486357 3884 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_871 0574-0004 149 µM -1.09726112001529 0.180621203660905 no 2783 0.136263630884925 4155 9551173 SGTC_1120 ficusin 1.78878 µM -1.10200194705099 0.179587804358738 no 2784 0.135230412569974 4247 6199 A DNA cross-linker. SGTC_205 1486-1330 71.903 µM -1.10513622937099 0.178906642111319 no 2785 0.134550282069944 4235 4118834 SGTC_2727 riluzole 51.77 µM -1.10743671868473 0.178407721205489 no 2786 0.134052578947672 4224 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2971 9092186 9.93 µM -1.10847679295676 0.178182442084531 no 2787 0.133827978104666 4211 25236400 SGTC_1556 plumbagin 1.48 µM -1.10872375913379 0.178128975793606 no 2788 0.133774684540659 4120 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_426 0988-0037 14.6 µM -1.10935250276462 0.177992903254265 no 2789 0.133639071943025 4245 5383008 SGTC_2536 dehydroabietamide 32.04 µM -1.11323497216537 0.17715411277516 no 2790 0.132803763205063 4302 3983547 SGTC_3284 9108171 64.8615 µM -1.11536437127373 0.176695127452264 no 2791 0.132347155438545 4189 8687505 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.12001760783664 0.175694756302768 no 2792 0.131353129392995 4192 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2639 lactacystin 53 µM -1.12024860108172 0.175645190128351 no 2793 0.131303919196418 4265 3870 A proteasome inhibitor. SGTC_2036 5160441 105 µM -1.12380975597185 0.174882164502375 no 2794 0.130546870905821 4186 134534 YIL048W NEO1 SGTC_1485 3909-9022 254 µM -1.12551414911326 0.174517720672064 no 2795 0.1301856124513 4266 714516 SGTC_1771 st048882 4.1505 µM -1.12600420798825 0.174413022614797 no 2796 0.130081869092826 4245 4580403 SGTC_3012 9080433 71.4286 µM -1.1270444408537 0.174190915546806 no 2797 0.129861845929571 4227 17688859 SGTC_1817 st052116 64.4 µM -1.12768463834642 0.174054312101148 no 2798 0.129726563754875 4240 4361398 SGTC_798 1287-0182 476 µM -1.12769167487886 0.174052811045164 no 2799 0.129725077385219 4265 1649755 SGTC_1204 4049-0315 18.3 µM -1.12805235954547 0.173975879641524 no 2800 0.12964890356008 4267 588402 SGTC_3186 9110464 49.47 µM -1.1298507270933 0.173592623691707 no 2801 0.129269564537194 4228 17018021 SGTC_1965 Pectolinarigenin 58.4 µM -1.12996891319029 0.173567455495951 no 2802 0.12924466189671 4188 5320438 An anti-inflammatory. SGTC_2906 7926292 26.41 µM -1.13592451832044 0.172302193349967 no 2803 0.127994077986637 4225 2966319 SGTC_932 2857-0803 154 µM -1.13601877963437 0.172282215053658 no 2804 0.127974352401441 4272 674898 SGTC_3137 9097352 49.47 µM -1.13628920889972 0.172224906890321 no 2805 0.127917772768042 4262 44120435 SGTC_2976 9009005 19.48 µM -1.13753313585962 0.171961456126898 no 2806 0.127657740290618 4268 2993148 SGTC_218 alverine citrate 93.75 µM -1.13770843311692 0.171924350689896 no 2807 0.127621125433559 4261 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_6 0844-0013 19.835 µM -1.13855921838678 0.171744336300029 no 2808 0.127443523104787 4366 1584900 SGTC_3265 9137266 49.47 µM -1.13899332055676 0.171652532690492 no 2809 0.12735297007041 4174 17224265 SGTC_2492 derrusnin 100 µM -1.13916503552396 0.171616227189488 no 2810 0.12731716295189 4231 1715307 Part of coumarin class of compounds. SGTC_504 lovastatin 124 µM -1.1398255613946 0.171476618688894 no 2811 0.127179491096223 4246 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1961 st076550 68.7 µM -1.14256218932637 0.170898979597572 no 2812 0.126610205866957 4257 1579337 SGTC_692 k241-0027 77.8 µM -1.14389799999227 0.170617473462699 no 2813 0.126332970293109 4292 3600480 SGTC_538 2922-0838 53.3 µM -1.14692743955974 0.169980156005057 no 2814 0.125705805485626 4276 777039 SGTC_3046 9092212 49.47 µM -1.15067831514023 0.169193183969288 no 2815 0.124932300428034 4302 25236637 SGTC_1523 st012844 44.7 µM -1.15071870046368 0.169184723464884 no 2816 0.124923990305312 4326 4274103 SGTC_1195 1502-0147 41.1 µM -1.15505768405741 0.168277312696679 no 2817 0.124033402644617 4226 817940 SGTC_284 0988-0104 32.6 µM -1.1568602972142 0.16790125473142 no 2818 0.123664720984057 4227 4666532 SGTC_1266 0828-0227 32.9 µM -1.15686850491921 0.167899543692701 no 2819 0.123663044049943 4236 3913820 SGTC_2416 tofa 880 nM -1.15700836035291 0.167870390122703 no 2820 0.123634472328405 4242 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2973 9094665 17.96 µM -1.15817333687525 0.167627671539339 no 2821 0.123396653439517 4263 25237061 YIL048W NEO1 SGTC_502 l-744,832 89.3 µM -1.16030498916013 0.16718413511225 no 2822 0.122962326967081 4267 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_978 1416-0512 87.4 µM -1.16242740486213 0.166743272915471 no 2823 0.122530948416814 4327 6814003 SGTC_3309 9129340 25.759 µM -1.1627287558768 0.166680738001995 no 2824 0.122469785362554 4271 17158987 SGTC_590 k048-0076 22.4 µM -1.16347997137316 0.166524915271901 no 2825 0.122317409819575 4274 6832814 SGTC_2233 sulbentine 40.3845 µM -1.16543536112196 0.16611975482152 no 2826 0.121921405346112 4261 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.16674319915598 0.165849124030825 no 2827 0.121657045802304 4122 4000243 SGTC_1336 1486-0901 104 µM -1.1721991466245 0.164723201688342 no 2828 0.120558555479886 4277 5006114 SGTC_594 1487-1584 10.8 µM -1.17252564619278 0.164655980663659 no 2829 0.120493040861406 4213 5013332 SGTC_2166 5933061 31.504 µM -1.17259242602041 0.164642233957949 no 2830 0.120479644070768 4394 2877375 SGTC_1039 k821-0043 94 µM -1.17492972599981 0.164161566545832 no 2831 0.120011415906225 4264 15992768 SGTC_450 aminopyrene 156 nM -1.17593070945188 0.163955992220385 no 2832 0.119811283008973 4225 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2268 7933382 153.85 µM -1.17683123863208 0.163771191218712 no 2833 0.119631435746248 4289 935025 YOR257W CDC31 SGTC_1065 prochlorperazine maleate 2.48 µM -1.17805250785474 0.163520786033438 no 2834 0.119387836911648 4297 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2035 5154463 94.595 µM -1.17988213941738 0.16314610967602 no 2835 0.11902354720817 4286 2769623 SGTC_1447 4239-0816 81.9 µM -1.18161269102212 0.162792236989539 no 2836 0.11867970777992 4265 1341554 SGTC_1656 st012921 11 µM -1.18166340167453 0.162781874930897 no 2837 0.118669642788309 4162 6732821 SGTC_3231 9132313 49.47 µM -1.18214101099173 0.162684302758706 no 2838 0.118574877031571 4206 4905967 SGTC_2955 9076254 12.21 µM -1.18901803976551 0.161283593657254 no 2839 0.117216284100125 4184 16459619 SGTC_1966 st070145 16.1 µM -1.19077007542414 0.160928001210231 no 2840 0.116871929751565 4263 3748532 SGTC_1881 5652484 16 µM -1.19261682839799 0.160553739403511 no 2841 0.116509736066066 4256 2255129 SGTC_1878 temozolomide 1 mM -1.19317644834872 0.160440439515848 no 2842 0.116400138170716 4198 5394 DNA alkylating agent. SGTC_3184 9108758 49.47 µM -1.19363502488101 0.160347635692823 no 2843 0.116310383502368 4302 902885 SGTC_55 0767-0285 6.563 µM -1.19781706182456 0.159502920533298 no 2844 0.115494121725511 4201 3116166 SGTC_1459 k035-0031 35.7 µM -1.20091123841085 0.158879816806266 no 2845 0.114892817164838 4020 3877128 YMR208W ERG12 SGTC_1009 4106-0057 9.87 µM -1.20136130036437 0.158789316635865 no 2846 0.114805540550542 4291 2928005 SGTC_167 3672-0051 66.205 µM -1.20171048043569 0.158719125461627 no 2847 0.114737859585514 4194 3237971 SGTC_2435 5706476 10.6 µM -1.2018587264933 0.158689331617443 no 2848 0.114709133896921 4279 5725375 SGTC_3227 9130768 49.47 µM -1.20247104718242 0.158566308937713 no 2849 0.114590538530923 4342 17720899 SGTC_415 dibenzyl ketone 100 µM -1.20313234812418 0.158433515797046 no 2850 0.114462554623626 4266 7593 SGTC_1745 st081495 74 µM -1.20378368982655 0.158302793860714 no 2851 0.114336597663039 4155 13842402 YBL026W LSM2 SGTC_1172 0370-0043 85 µM -1.20382901692289 0.158293699510075 no 2852 0.114327835948536 4314 376585 SGTC_2390 9097792 176.6 µM -1.20618623471213 0.157821223871851 no 2853 0.113872845156248 4314 4497149 SGTC_230 MPP+ 141.667 µM -1.21308290242292 0.156444195106175 no 2854 0.112549063085868 4267 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_216 k038-0035 28.382 µM -1.21429134191243 0.15620372815423 no 2855 0.112318245342705 4209 4444231 YPR107C YTH1 SGTC_3260 9137109 49.47 µM -1.21550413459594 0.155962639922328 no 2856 0.112086936402403 4241 17478346 SGTC_570 0987-0065 62.6 µM -1.21551485407215 0.155960510116707 no 2857 0.112084893458015 4123 3104428 SGTC_1575 cyproterone acetate 48 µM -1.21664302621244 0.155736465733161 no 2858 0.111870032411284 4318 9880 An androgen receptor antagonist and liver toxin. SGTC_325 2810-4341 181 µM -1.21682504992708 0.155700337428211 no 2859 0.111835393502326 4293 774970 SGTC_3218 9131285 49.47 µM -1.21753773728479 0.155558935499727 no 2860 0.111699843710486 4288 17156417 SGTC_8 0354-0001 70 µM -1.22538942394294 0.154006717395542 no 2861 0.110214264910277 4291 4993152 SGTC_967 1306-0166 352 µM -1.2273769244267 0.153615434799336 no 2862 0.109840477656755 4326 4437607 SGTC_1319 1306-0155 43.7 µM -1.22817244497795 0.153459003946517 no 2863 0.109691120147375 4351 3122360 SGTC_1102 cgs 12066b 26.1 µM -1.23104842175353 0.152894353494542 no 2864 0.109152377293068 4317 6438352 A 5-HT1B full agonist. SGTC_1897 st060201 15 µM -1.23149664254641 0.152806476998118 no 2865 0.109068585807411 4320 611878 SGTC_1393 3470-5649 58.2 µM -1.23368718768385 0.152377488842081 no 2866 0.108659744994803 4284 4108395 SGTC_612 0302-0167 22.4 µM -1.24015187493998 0.151116133345553 no 2867 0.107459612380856 4323 235821 SGTC_1824 st053723 68.6 µM -1.24021395073275 0.151104055217789 no 2868 0.107448134856253 4322 675225 SGTC_148 3253-0744 288.01 µM -1.24351388580844 0.150462909308205 no 2869 0.106839263632381 4187 6893655 SGTC_113 0099-0221 2.5 µM -1.24354461841088 0.150456946787004 no 2870 0.106833604882343 4283 89219 SGTC_989 1501-0895 10.3 µM -1.24364779288359 0.150436930760051 no 2871 0.106814609096237 4275 2830112 SGTC_627 1391-0720 175 µM -1.24419130228116 0.150331518281415 no 2872 0.106714582056145 4292 997839 SGTC_2610 ononetin 44.17 µM -1.24455198462987 0.150261591891245 no 2873 0.106648239688214 4299 259632 SGTC_1209 2323-2347 50.3 µM -1.24576500696887 0.150026579275189 no 2874 0.106425339967862 4324 5412760 SGTC_3244 9134489 49.47 µM -1.25060108979059 0.149092067216184 no 2875 0.105540026408113 4342 16584271 SGTC_237 nikkomycin 200 µM -1.25119770885016 0.1489770481076 no 2876 0.105431176968425 4343 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1171 0368-0077 21.4 µM -1.25460535452864 0.148321242146479 no 2877 0.104811029356549 4284 3239779 SGTC_850 0388-0143 75.9 µM -1.2546747437342 0.148307908193839 no 2878 0.104798428913746 4308 67273 SGTC_633 0437-0093 97.7 µM -1.25512270269953 0.148221846903865 no 2879 0.104717110075551 4268 2831118 SGTC_2428 5615643 7.78 µM -1.26049974913124 0.147191423579048 no 2880 0.10374456916693 4334 2253075 SGTC_65 0798-0905 34.986 µM -1.26099699202615 0.147096378239276 no 2881 0.103654965443543 4390 3602145 SGTC_1907 st060210 83.7 µM -1.26438754687925 0.146449388746585 no 2882 0.103045480205833 4352 688793 SGTC_1612 st002233 45.4 µM -1.26550684732077 0.146236222634846 no 2883 0.102844847689905 4345 1035021 SGTC_293 4049-0273 38.5 µM -1.26688688856049 0.145973686499444 no 2884 0.102597868786409 4219 1380311 SGTC_1732 st034308 51.822 µM -1.2676498066965 0.145828686574769 no 2885 0.102461518435576 4207 830119 SGTC_1685 st024049 53.0905 µM -1.26768381092883 0.145822225997864 no 2886 0.102455444195476 4361 1941139 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.26777587083702 0.145804736195922 no 2887 0.102439000674577 4347 5377381 SGTC_3014 9081533 49.47 µM -1.26822886302936 0.145718695995554 no 2888 0.102358116243373 4379 21367265 SGTC_778 3456-2434 196 µM -1.26998943013866 0.14538462245357 no 2889 0.102044197620337 4294 5539063 SGTC_2062 5245942 200 µM -1.27511507007605 0.144414950236296 no 2890 0.101134258048948 4384 1376160 SGTC_1089 terbinafine 2.25 µM -1.27626612854807 0.144197792840469 no 2891 0.100930729668395 4354 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_222 nsc-310342 10.666 µM -1.27639075119616 0.144174294886539 no 2892 0.100908712012324 4366 432556 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.27643344358219 0.144166245709725 no 2893 0.100901170157595 4339 641818 YHR062C RPP1 SGTC_2134 5324836 1.464 µM -1.2770114429407 0.144057300147403 no 2894 0.100799103701056 4314 699272 SGTC_740 k014-0057 261 µM -1.27776496064846 0.143915354986443 no 2895 0.100666156283787 4344 4012779 SGTC_3130 9127414 49.47 µM -1.27907720001572 0.143668384974569 no 2896 0.100434935811597 4360 1494646 SGTC_7 0192-1582 4.227 µM -1.28119385717602 0.143270622582978 no 2897 0.100062791612084 4396 252616 SGTC_1968 st069590 43.6 µM -1.28394543420737 0.142754658812468 no 2898 0.0995805242205373 4312 6384066 SGTC_876 0720-0963 56.8 µM -1.28425749474694 0.14269622198426 no 2899 0.0995259369677558 4376 765861 SGTC_1318 1280-3875 124 µM -1.28569603731297 0.142427047926813 no 2900 0.0992745823777343 4360 373245 SGTC_112 phenothiazine 287.218 µM -1.28580339463903 0.142406973455478 no 2901 0.0992558426065339 4309 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_787 4152-0075 138 µM -1.29109854821099 0.141419221190567 no 2902 0.0983347537168475 4370 9566539 SGTC_3316 9136639 10.545 µM -1.29327526324606 0.141014528940223 no 2903 0.0979579364924278 4346 4903665 SGTC_2493 resveratrol 26.09 µM -1.29381317313769 0.14091464253038 no 2904 0.0978649806831507 4278 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2645 abamectin 100 µM -1.29389076222437 0.140900238697427 no 2905 0.0978515779079299 4312 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_843 0310-0051 143 µM -1.29402293695981 0.140875703747531 no 2906 0.0978287490803807 4380 2065037 SGTC_1109 tnp00067 928.257 nM -1.29641283007774 0.140432579538136 no 2907 0.0974166470898487 4360 676295 SGTC_2063 5246145 200 µM -1.29953687346804 0.139854760690558 no 2908 0.0968798738208161 4413 711240 SGTC_776 4476-4378 112 µM -1.30026697072227 0.139719956178074 no 2909 0.0967547421275521 4417 2892008 SGTC_1440 4100-1550 40 µM -1.30048943838268 0.139678897511661 no 2910 0.0967166369001322 4360 742806 SGTC_1952 st077036 64.1 µM -1.30572893737086 0.138714266302944 no 2911 0.0958223768225896 4384 2937007 SGTC_3017 9080681 49.47 µM -1.30628702462034 0.138611786294948 no 2912 0.0957274839722426 4386 16451914 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.3063313039277 0.138603657618144 no 2913 0.0957199580217356 4370 5024745 SGTC_3101 9120531 49.47 µM -1.30792975029648 0.138310436569851 no 2914 0.0954485688491994 4368 24824904 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.31002828304513 0.137926121433986 no 2915 0.0950931338983917 4448 4213774 SGTC_1422 4031-0024 15.5 µM -1.31022230099314 0.137890626748877 no 2916 0.095060321777128 4315 782427 SGTC_2853 9015042 58.44 µM -1.31287804415123 0.137405397240033 no 2917 0.0946120231654765 4298 6457456 SGTC_180 1486-1293 102.781 µM -1.31343390997679 0.137303983006196 no 2918 0.0945183886462864 4324 4140536 SGTC_1693 xanthone 101.9 µM -1.31468978540808 0.13707504466036 no 2919 0.0943070904458461 4412 7020 An insecticide. SGTC_2543 pimpinellin 60.67 µM -1.31514523208153 0.136992084019043 no 2920 0.0942305487157941 4218 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3038 9091290 49.47 µM -1.31751015735506 0.136561859205078 no 2921 0.0938338393084594 4398 25236843 SGTC_630 4356-0227 183 µM -1.31870886276281 0.136344145173069 no 2922 0.0936332313401256 4326 779312 SGTC_2312 7706453 155.7 µM -1.3188068360633 0.136326361344194 no 2923 0.0936168491409049 4367 976098 SGTC_534 k292-0788 63.4 µM -1.31893832118525 0.136302497041079 no 2924 0.0935948667277382 4418 4146317 SGTC_2791 5663188 71.43 µM -1.31992935192252 0.136122718782416 no 2925 0.0934293033244556 4395 54690634 SGTC_3195 9113082 49.47 µM -1.32010636405602 0.136090624928576 no 2926 0.0933997541390708 4380 17018038 SGTC_2397 5161689 200 µM -1.32201684349094 0.135744567842426 no 2927 0.0930812711059979 4430 2259942 SGTC_1839 st053978 48 µM -1.32662610564558 0.134912146152017 no 2928 0.0923161979025331 4416 3788398 SGTC_452 diindolylmethane 8 µM -1.32892111064543 0.134498982251435 no 2929 0.0919369991206387 4381 3071 Inhibits expression of several cancer promoting factors. SGTC_726 3448-4391 34.2 µM -1.33078191610523 0.134164624480265 no 2930 0.0916303899828125 4483 1356692 SGTC_2223 6903751 107.57 µM -1.33133320245975 0.134065676633802 no 2931 0.0915396989271851 4349 5598863 SGTC_969 1313-0238 134 µM -1.3327596156154 0.133809889046546 no 2932 0.0913053512051417 4425 5212874 SGTC_730 1436-0052 41.2 µM -1.33534946413007 0.133346329540357 no 2933 0.0908809982325392 4426 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_651 3253-0966 34.4 µM -1.33717415249728 0.133020390948701 no 2934 0.0905828984535328 4400 781462 SGTC_2026 5148700 152 µM -1.33725020330668 0.133006818136879 no 2935 0.0905704897897066 4369 79838 SGTC_2930 9013230 14.89 µM -1.33908201701226 0.13268018178488 no 2936 0.0902719870356458 4372 2995857 SGTC_1225 1216-0074 20.6 µM -1.34052357813619 0.1324235213763 no 2937 0.0900375920449726 4407 4241466 SGTC_2205 7238770 200 µM -1.34312896098117 0.131960518669657 no 2938 0.0896151096686008 4447 279867 SGTC_1633 st005664 67.9 µM -1.34347848022693 0.13189849063229 no 2939 0.0895585448249849 4378 2063822 SGTC_57 miconazole 162.5 nM -1.3436308656915 0.131871453578986 no 2940 0.0895338916634356 4242 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2148 5546263 113.568 µM -1.34548219724887 0.131543285675775 no 2941 0.0892347833174502 4415 792097 SGTC_835 0312-0010 67.2 µM -1.35061027955305 0.130637224249276 no 2942 0.0884101530870862 4412 1626196 SGTC_1770 st043884 66.3 µM -1.35252480150256 0.13030006338468 no 2943 0.0881037451259092 4417 670149 SGTC_683 panaxydol 45 µM -1.35425505364886 0.129995872033605 no 2944 0.0878275101546462 4418 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1619 st003326 88.7 µM -1.35562177343855 0.129755940161559 no 2945 0.0876097702367506 4388 2849032 SGTC_193 1273-0060 1.558 µM -1.35671740115222 0.129563820927787 no 2946 0.0874355106149459 4237 2847393 YHR072W ERG7 SGTC_1880 MG-132 525 µM -1.35824194957697 0.129296818102516 no 2947 0.0871934617700573 4362 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2670 beta-carotene 100 µM -1.3599358711958 0.129000599531844 no 2948 0.0869251091561681 4374 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3068 9116768 49.47 µM -1.36138868929149 0.128746918258866 no 2949 0.0866954443033113 4366 41904888 SGTC_2612 dictamnine 15.46 µM -1.36391900540037 0.12830591833911 no 2950 0.0862965292641982 4338 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2868 9035608 32.47 µM -1.36756663246064 0.127672033816185 no 2951 0.0857238834859949 4387 6462614 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.36771508578327 0.127646281785575 no 2952 0.0857006379923644 4470 279621 SGTC_856 0433-0016 11.3 µM -1.36821434027386 0.127559703164483 no 2953 0.0856224970839742 4441 3911780 SGTC_2059 5238311 157 µM -1.36851521714712 0.127507546080157 no 2954 0.0855754310540198 4364 703021 SGTC_1610 st001799 48.1 µM -1.36906994056409 0.127411423509346 no 2955 0.0854887067161719 4373 621897 SGTC_2260 7964312 200 µM -1.37078169284853 0.127115128510686 no 2956 0.0852215097587355 4470 231951 SGTC_2625 euphol 100 µM -1.37145209687282 0.126999215989501 no 2957 0.0851170333527834 4413 6708538 A triterpene alcohol. SGTC_1072 oxiconazole 14.9 nM -1.37199626960685 0.126905182902263 no 2958 0.0850322995523655 4408 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_642 0335-0876 158 µM -1.37343732456125 0.126656402654932 no 2959 0.0848082165403895 4456 6812350 SGTC_291 SEC14.278 35.5 µM -1.37478209339217 0.126424551561111 no 2960 0.0845995056088496 4440 1068044 SGTC_2879 9041815 71.43 µM -1.37485855949164 0.126411376960183 no 2961 0.0845876494970259 4454 4942971 SGTC_1142 3253-1408 9.78 µM -1.3812692478958 0.125310258193322 no 2962 0.0835980949548422 4439 256655 SGTC_1752 st044819 83.042 µM -1.38231184963148 0.125131812837085 no 2963 0.0834379845696589 4367 441209 YML126C ERG13 SGTC_1691 st019933 84.6 µM -1.38311831678121 0.12499390461492 no 2964 0.0833142950990138 4403 6176082 SGTC_1548 st061468 90.8 µM -1.38335610486497 0.124953262437537 no 2965 0.0832778513936608 4453 390799 SGTC_517 1365-0151 113 µM -1.38873735877713 0.124035978900098 no 2966 0.0824563147831054 4427 768657 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.38929837511627 0.123940620506154 no 2967 0.082371018899818 4523 688664 SGTC_2439 5492030 7.2 µM -1.39031365457892 0.123768179497934 no 2968 0.082216826632373 4434 5722370 SGTC_3199 9111318 49.47 µM -1.39090894325934 0.123667150331207 no 2969 0.0821265202576118 4351 8548020 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.39437465082374 0.123080115956806 no 2970 0.0816022494057787 4424 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_917 harmaline 728.087 nM -1.39476410348885 0.123014271307663 no 2971 0.0815434934848599 4367 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1456 k015-0012 13 µM -1.39482396227642 0.123004153189641 no 2972 0.081534465542109 4450 2989616 SGTC_2520 obtusaquinone 4.71 µM -1.39531383544781 0.122921370320647 no 2973 0.0814606108617407 4470 5967872 SGTC_2523 spermine 47.74 µM -1.39974080089938 0.12217503603351 no 2974 0.080795475500141 4453 1103 A DNA binding polyamine. SGTC_2958 9077254 16.72 µM -1.40053699506647 0.122041145337842 no 2975 0.0806762865428762 4469 16457351 SGTC_1126 isoteolin 1.0172 µM -1.4011442610509 0.121939094733963 no 2976 0.0805854691209011 4374 133323 SGTC_2339 9000433 200 µM -1.40146893212323 0.121884558594266 no 2977 0.0805369458271162 4418 2988954 SGTC_2742 clothiapine 36.27 µM -1.40222097497152 0.121758301131193 no 2978 0.0804246350129655 4478 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3098 9119039 49.47 µM -1.40332601529836 0.121572947099307 no 2979 0.0802598219491798 4436 17161528 SGTC_399 oxolinic acid 75 µM -1.40558780975063 0.121194183425804 no 2980 0.0799232789760349 4401 4628 A DNA gyrase inhibitor. SGTC_279 1273-0055 2.93 µM -1.4062051319303 0.121090950010042 no 2981 0.0798316103578716 4473 2847562 SGTC_3188 9110789 49.47 µM -1.40842158642687 0.120720807079941 no 2982 0.0795031354843066 4412 849217 SGTC_231 b-estradiol 524 µM -1.40859598071931 0.120691717459469 no 2983 0.0794773340068664 4423 450 A steroid. SGTC_2359 9039622 200 µM -1.40907471314934 0.120611888465778 no 2984 0.0794065385522028 4403 6463596 SGTC_2273 7815444 169.05 µM -1.40925215255084 0.120582309756989 no 2985 0.0793803107545229 4380 2824616 SGTC_3102 9121669 49.47 µM -1.41050014645507 0.120374416551875 no 2986 0.0791960266124436 4483 41905072 SGTC_3141 9094609 49.47 µM -1.41247185464167 0.120046480393375 no 2987 0.0789055361313387 4406 25236309 YDL196W YDL196W SGTC_1160 4092-0570 10.5 µM -1.41685849554214 0.119319150666023 no 2988 0.0782621516252405 4454 4994975 SGTC_976 1348-1067 47.6 µM -1.42151709523736 0.118550139675346 no 2989 0.0775832436612982 4479 5310671 YGL099W LSG1 SGTC_386 1509-0011 3.07 µM -1.42179098210486 0.118505037496794 no 2990 0.077543469141709 4461 3107280 SGTC_1646 st011709 75.6 µM -1.42218385411836 0.118440362676754 no 2991 0.0774864423459641 4417 5757843 SGTC_3325 9138760 55.175 µM -1.42235200610003 0.118412689025041 no 2992 0.0774620442118473 4401 43844959 SGTC_1570 verbenone 133 µM -1.42327534999159 0.11826081094278 no 2993 0.0773281749230273 4464 29025 A natural terpanoid with antifungal properties. SGTC_228 caffeine 993.056 µM -1.4234216908318 0.118236752424842 no 2994 0.077306974113093 4433 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2692 st077426 47.7 µM -1.42961817693007 0.117221220588462 no 2995 0.0764133178449422 4444 25238571 SGTC_1733 st037357 54.9 µM -1.43334826377567 0.116612890166445 no 2996 0.0758791678091969 4366 1272339 YGL099W LSG1 SGTC_1625 st003711 30.1 µM -1.43336554020832 0.116610077815065 no 2997 0.0758767004491793 4475 24207034 YER133W GLC7 SGTC_999 SEC7.066 22.7 µM -1.43458365073653 0.116411908413372 no 2998 0.0757028881195695 4412 740511 YDR170C SEC7 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.4364436619252 0.116109771940954 no 2999 0.0754380682988172 4461 688667 SGTC_1531 st059297 52.4 µM -1.43929000811733 0.115648495458604 no 3000 0.0750341863124195 4490 7566702 SGTC_541 4513-1321 94 µM -1.44538070760071 0.114665818470557 no 3001 0.0741754896712078 4418 747515 SGTC_1369 1866-0067 208 µM -1.44703898794938 0.114399302652871 no 3002 0.0739430021526822 4481 3531355 SGTC_765 1319-0117 244 µM -1.44961158643329 0.113986712573276 no 3003 0.0735834315852953 4436 3487746 YGL099W LSG1 SGTC_3104 9120930 49.47 µM -1.45529484896018 0.113078998858878 no 3004 0.072793826032361 4500 17014836 SGTC_3248 9135562 49.47 µM -1.45557754893635 0.113033981923336 no 3005 0.0727547190750957 4470 17650701 SGTC_1786 berberine 21.6 µM -1.46664144404846 0.111282210129418 no 3006 0.0712368098339714 4377 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1118 chelidonine 707.474 nM -1.46967042379574 0.110806031649843 no 3007 0.0708255183745878 4464 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_918 glabranin 770.725 nM -1.47149134395733 0.110520472833239 no 3008 0.0705791433673125 4489 124049 Also referred to as licorice root. SGTC_2271 7849410 118.62 µM -1.47219066339396 0.110410945071442 no 3009 0.0704846989816978 4402 972430 SGTC_381 3461-2219 42.7 µM -1.47254700810303 0.11035516412545 no 3010 0.0704366113491247 4450 2883159 SGTC_2057 5236571 38.335 µM -1.47991434656443 0.109206431685964 no 3011 0.0694480532499802 4430 54684039 YBR257W POP4 SGTC_264 promethazine 12.5 mM -1.48128362096617 0.108993881520341 no 3012 0.0692655056192422 4354 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_928 2764-0428 58.7 µM -1.48254670957595 0.108798078205275 no 3013 0.0690974423441687 4502 662578 SGTC_82 0054-0107 293.755 µM -1.48307586966666 0.108716123313607 no 3014 0.0690271271551504 4453 3104697 SGTC_342 k048-0088 23.3 µM -1.48664199079531 0.108164969658884 no 3015 0.0685546956142941 4478 6820570 SGTC_862 0452-0056 10.2 µM -1.49082749784595 0.107520657409477 no 3016 0.0680033951764476 4444 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2754 granisetron 64.02 µM -1.49333099225426 0.10713659672836 no 3017 0.0676752833946458 4480 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2794 7785382 27.27 µM -1.4935250502583 0.107106867688688 no 3018 0.0676499010219269 4483 2205081 SGTC_2659 sanguinarine 24.21 µM -1.49499083155458 0.106882507045245 no 3019 0.0674584174789421 4445 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2333 9017922 200 µM -1.49622455226738 0.106693929848287 no 3020 0.0672975742409981 4493 3163164 SGTC_1588 farnesol 29.9 µM -1.49743472826355 0.106509184927014 no 3021 0.0671400887810997 4500 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1797 st048695 56.8 µM -1.49837672686758 0.106365539776816 no 3022 0.0670176997781207 4446 592262 YIL048W NEO1 SGTC_1510 1123-0200 71.5 µM -1.4995937329787 0.106180165987237 no 3023 0.0668598360314053 4491 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_792 4534-1957 155 µM -1.49993091417486 0.10612884801895 no 3024 0.0668161495624595 4457 1717904 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.50207541085932 0.105802881385512 no 3025 0.0665388172093075 4585 16725076 SGTC_580 1123-0028 41 µM -1.50415441447776 0.105487561270573 no 3026 0.0662708060814291 4546 1677248 YPR107C YTH1 SGTC_48 0382-0018 55 µM -1.50703078559247 0.105052426802 no 3027 0.0659013831608854 4523 762596 SGTC_2835 9006588 71.43 µM -1.50753230268444 0.104976691009822 no 3028 0.065837135177134 4470 2345538 SGTC_3292 9120825 59.784 µM -1.50818656647411 0.104877947848194 no 3029 0.0657533922202263 4467 24824900 SGTC_593 1203-0218 61.7 µM -1.51460067105132 0.103913474282752 no 3030 0.0649367810827966 4545 3666956 SGTC_2788 5282734 71.43 µM -1.51501312420198 0.10385167553628 no 3031 0.0648845402653583 4523 743706 SGTC_443 clozapine 122 µM -1.516562820139 0.103619719493298 no 3032 0.0646885492086095 4498 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_564 3555-0129 330 µM -1.52845419271023 0.101852338175805 no 3033 0.0631999042246253 4409 563260 SGTC_2518 prenyletin 46.28 µM -1.53214365453372 0.101308469577591 no 3034 0.0627434945985314 4538 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2391 6285546 200 µM -1.53456048451043 0.100953350212882 no 3035 0.0624459126796837 4525 846083 SGTC_2238 6671620 73.2395 µM -1.53966186695607 0.100206754500123 no 3036 0.0618213982652229 4428 729941 SGTC_2354 9060492 162 µM -1.54150851278919 0.0999374908463729 no 3037 0.0615965363491164 4522 6471895 SGTC_1597 7-benzyloxygramine 47.5 µM -1.54172315684573 0.0999062274171891 no 3038 0.0615704411101252 4417 260807 SGTC_3349 9149703 23.001 µM -1.54653274742128 0.0992075710263872 no 3039 0.0609879788028329 4536 4910494 SGTC_1343 1487-0095 224 µM -1.54719550061661 0.0991115781630953 no 3040 0.0609080553090265 4510 4560101 YGL055W OLE1 SGTC_133 0724-0033 378.92 µM -1.54819096143425 0.0989675237547396 no 3041 0.0607881634551216 4419 280309 SGTC_1169 aniline yellow 25.8 µM -1.5490483657787 0.0988435705052903 no 3042 0.0606850469259908 4461 6051 A DNA damaging agent. SGTC_1572 epiandrosterone 68.9 µM -1.55035214588488 0.0986553033548458 no 3043 0.0605285088585799 4460 441302 A steroid. SGTC_2146 5545642 200 µM -1.55195639999348 0.0984240078056915 no 3044 0.0603363281680383 4474 825326 SGTC_2778 tioconazole 65.09 nM -1.55409985348094 0.0981155924769384 no 3045 0.0600803000838505 4417 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1170 0310-0127 64.8 µM -1.56101916858616 0.0971248249763414 no 3046 0.0592596140913619 4529 774975 SGTC_23 0213-0011 39.996 µM -1.56445613230293 0.0966354289114189 no 3047 0.0588552436407827 4514 627608 SGTC_2284 7945075 39.21 µM -1.5662283728917 0.0963837850041549 no 3048 0.0586475813066243 4487 1245402 SGTC_1934 st074720 32.6 µM -1.57743899434307 0.0948031164561428 no 3049 0.0573472744550815 4483 17250992 SGTC_1978 st071761 42 µM -1.57944710027322 0.0945220076032116 no 3050 0.0571167705684404 4535 5147680 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.58240162464059 0.0941095303372297 no 3051 0.0567789570405832 4435 4330530 SGTC_1387 3342-1166 1.8 µM -1.58934460654345 0.0931454596130603 no 3052 0.0559913066138339 4533 3418228 SGTC_471 1-acyl-paf 4 µM -1.59003803916885 0.0930495750746424 no 3053 0.0559131154747734 4513 16759367 SGTC_1478 0453-0656 35.7 µM -1.5902385329948 0.0930218653509707 no 3054 0.0558905239452103 4578 5258496 SGTC_964 1287-0107 19.4 µM -1.59180396483098 0.0928057208470181 no 3055 0.0557143795097543 4532 51516812 YPR165W RHO1 SGTC_247 mechlorethamine 29.705 µM -1.5939720355844 0.0925069815970172 no 3056 0.0554711492234966 4515 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.59585289662081 0.0922483939121697 no 3057 0.0552608200584498 4526 5379071 SGTC_153 4077-0274 519.67 µM -1.59919433302002 0.091790321162794 no 3058 0.0548887145674384 4555 3121976 SGTC_3234 9132280 49.47 µM -1.59970250716163 0.0917208041641522 no 3059 0.0548322977076316 4562 17612295 SGTC_2664 lyso-paf C-16 73.48 µM -1.59973986196097 0.0917156956569449 no 3060 0.0548281524334572 4526 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_970 1315-0089 19.5 µM -1.60842620462073 0.0905334986010124 no 3061 0.0538709331653928 4529 6811083 YLR033W RSC58 SGTC_2691 st077356 60.2 µM -1.60942610068263 0.0903981437724357 no 3062 0.0537616009399943 4523 2839272 SGTC_2421 5690543 90.72 µM -1.6099669639333 0.09032499036424 no 3063 0.053702534288147 4535 3397993 SGTC_785 1270-0111 65.3 µM -1.61239220866915 0.0899975090909606 no 3064 0.0534383096222224 4468 6741994 SGTC_1213 1315-0166 115 µM -1.61435121950438 0.0897336282768674 no 3065 0.0532256330592092 4546 768401 SGTC_2461 5755302 26.15 µM -1.61478441036675 0.0896753547502685 no 3066 0.0531786951669557 4551 2788904 SGTC_2502 avocadyne acetate 18.59 µM -1.61781257557027 0.0892687867035958 no 3067 0.0528514977058089 4495 3952079 SGTC_1023 4482-3888 16 µM -1.61814649645383 0.0892240378484452 no 3068 0.0528155150631369 4562 3303168 SGTC_1159 4092-0538 61.2 µM -1.62199364808192 0.088709683053494 no 3069 0.0524023540969082 4567 717301 SGTC_85 0868-0259 160.055 µM -1.62500071889094 0.0883091850956732 no 3070 0.0520812028258683 4504 83173 SGTC_121 0557-0495 61.343 µM -1.62626946177022 0.0881406118544753 no 3071 0.0519461725952475 4582 3104427 SGTC_1863 st057641 20.1 µM -1.62837551225566 0.0878613183817969 no 3072 0.0517226433632066 4616 3921635 SGTC_3298 9116858 71.43 µM -1.62872317245341 0.0878152770377583 no 3073 0.0516858174944207 4603 2506942 SGTC_813 k007-0158 173 µM -1.62974420104008 0.0876801641915123 no 3074 0.0515777856378241 4555 6523916 SGTC_1153 4055-0057 267 µM -1.62999595909533 0.0876468728638836 no 3075 0.0515511755134132 4592 882706 SGTC_632 0781-2353 4.65 µM -1.63093576306879 0.0875226808212425 no 3076 0.0514519372777284 4582 6811515 YHR007C ERG11 SGTC_1569 carminic acid 40.6 µM -1.63341075934762 0.0871962464909368 no 3077 0.0511913178307684 4621 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_277 nystatin 15.5 µM -1.63436258328704 0.087070950044419 no 3078 0.0510913699575199 4585 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2875 9039966 71.43 µM -1.63483160808784 0.0870092579144781 no 3079 0.0510421763691792 4553 6463691 SGTC_2768 sulfasalazine 50.2 µM -1.63834404475857 0.0865482948150291 no 3080 0.0506749722940308 4535 5384001 An antioxidant and salicylic acid derivative. SGTC_1997 st073024 93.8 µM -1.64458627827286 0.0857335892687313 no 3081 0.0500275792403769 4603 686268 SGTC_719 2810-4230 27.3 µM -1.64491842412649 0.085690400645909 no 3082 0.0499933174579905 4578 721079 SGTC_1497 4476-2978 41.3 µM -1.64689716527663 0.0854334442406795 no 3083 0.049789592334776 4616 1528379 SGTC_1304 1165-0502 251 µM -1.65160295161943 0.0848246766358629 no 3084 0.0493077589674071 4563 767425 SGTC_2376 9072922 81.32 µM -1.65502144668218 0.0843844841149414 no 3085 0.0489600737961562 4549 17087968 SGTC_2168 5727979 200 µM -1.65568863755544 0.0842987716034008 no 3086 0.0488924447536861 4485 695210 SGTC_972 1319-0219 195 µM -1.65853422232056 0.0839339392080672 no 3087 0.0486048429845946 4560 23903702 SGTC_2926 9010726 65.15 µM -1.66433004318216 0.0831945259680985 no 3088 0.0480232458726414 4554 2994293 SGTC_76 0433-0009 400.328 µM -1.66541460635976 0.0830567063653165 no 3089 0.0479150336624537 4609 2841569 SGTC_2545 solidagenone 89.61 µM -1.67449419276803 0.0819096572253732 no 3090 0.0470167573814985 4534 6708572 An anti ulcer agent SGTC_425 3825-7017 13.1 µM -1.67456659708319 0.0819005584119195 no 3091 0.0470096488097476 4578 3397440 SGTC_948 3448-0295 75.3 µM -1.68109896986562 0.0810827871316498 no 3092 0.0463718462346364 4551 678569 SGTC_2004 4023728 41.89 µM -1.68172432040565 0.0810048254232075 no 3093 0.046311154878013 4527 360084 YDR527W RBA50 SGTC_3067 9117431 49.47 µM -1.68184256830647 0.0809900899608114 no 3094 0.046299685886926 4586 17150885 SGTC_581 0958-0271 211 µM -1.68682762235335 0.0803707163843309 no 3095 0.0458182512195329 4594 4591145 SGTC_2899 9053889 58.44 µM -1.68931228526266 0.0800633463338657 no 3096 0.0455798001482944 4588 6470052 SGTC_2795 7780010 54.55 µM -1.69720343233733 0.0790930492306417 no 3097 0.0448291032223697 4550 953673 SGTC_741 4582-0002 126 µM -1.7070292517147 0.0778973440401175 no 3098 0.0439083077794893 4613 2912688 SGTC_2925 9010536 32.5 µM -1.71817500309392 0.0765576779498477 no 3099 0.042882349757251 4518 2994177 SGTC_1653 st012112 65 µM -1.72348411587168 0.0759257426632071 no 3100 0.0424005075937103 4570 720429 SGTC_2989 9073649 71.4286 µM -1.72665508966067 0.0755502058995327 no 3101 0.0421148129000163 4563 21367202 SGTC_3003 9075612 71.4286 µM -1.72708568595941 0.0754993199401342 no 3102 0.0420761379616327 4605 6501993 SGTC_2913 7966556 36.57 µM -1.72834248357717 0.0753509465397942 no 3103 0.0419634203352705 4503 2976516 SGTC_340 k038-0059 454 µM -1.73226413424391 0.074889398009514 no 3104 0.0416132723407073 4588 23733424 SGTC_2798 7813637 45.45 µM -1.73643348754939 0.0744010653947363 no 3105 0.0412436076910388 4595 956368 SGTC_1511 0906-3109 28.5 µM -1.74411312958673 0.0735079610231581 no 3106 0.0405696825266042 4608 2882180 SGTC_2323 6148992 148.28 µM -1.74695854700997 0.0731791425546155 no 3107 0.0403222644475687 4566 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1490 4089-0339 670 nM -1.75105043268931 0.0727082557831211 no 3108 0.0399686116126623 4614 742542 SGTC_840 0245-0196 390 µM -1.75134006458906 0.0726750136033592 no 3109 0.0399436751803275 4674 3827528 SGTC_3129 9127257 49.47 µM -1.75826376524974 0.0718838137069004 no 3110 0.0393513199992822 4555 837894 SGTC_2086 5274770 176.623 µM -1.76307719097637 0.0713376677230054 no 3111 0.0389437357953809 4638 689278 SGTC_807 1315-0151 48 µM -1.76772430381005 0.0708134194686309 no 3112 0.0385535024499963 4604 4011080 SGTC_2460 5552655 174.22 µM -1.77950655175679 0.0694975130292613 no 3113 0.0375783758570427 4596 5401989 SGTC_3192 9110362 49.47 µM -1.78042505854412 0.0693957256596095 no 3114 0.0375032119088643 4600 16649480 SGTC_839 0122-0028 230 µM -1.78391294265328 0.0690102498654514 no 3115 0.0372189062407941 4639 759448 SGTC_1261 0712-0010 12.7 µM -1.79153455468271 0.0681736657574932 no 3116 0.0366037773282369 4610 2840123 SGTC_3311 9131146 2.8755 µM -1.79594081951193 0.06769359680818 no 3117 0.0362519647985298 4590 4900406 YPR165W RHO1 SGTC_226 1,3-diallylurea 8.28947 mM -1.79831161600048 0.067436377923483 no 3118 0.0360638199915021 4602 74537 YKL182W FAS1 SGTC_2560 caryophyllene 100 µM -1.81022407899231 0.0661553568670117 no 3119 0.0351305224944281 4660 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1651 st011928 86.1 µM -1.81037999917857 0.0661387156580883 no 3120 0.0351184393799237 4627 720198 SGTC_1895 st058434 18.3 µM -1.81713268172338 0.0654211150918193 no 3121 0.0345983998099355 4633 5393175 SGTC_1472 k841-0093 193 µM -1.81914029383989 0.0652089369708391 no 3122 0.0344450145181358 4671 X1472 SGTC_823 0417-1665 178 µM -1.82099194631494 0.0650137154218357 no 3123 0.034304040556287 4651 3429856 SGTC_1744 st037937 38.9 µM -1.82548749538113 0.064541632987908 no 3124 0.0339637482495345 4648 1016152 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.8337371655504 0.0636822582375931 no 3125 0.0333465094497657 4521 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2489 cantharidin 73.42 µM -1.8346656326633 0.0635860990585715 no 3126 0.0332776237141702 4591 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1389 3405-0187 19 µM -1.83890595718133 0.0631483741408879 no 3127 0.0329645097273027 4630 799890 SGTC_1564 D-Arginine 115 µM -1.8447556796646 0.0625483684038127 no 3128 0.0325365436232587 4625 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_491 tetrandrine 80.3 µM -1.84559414861537 0.0624627320621682 no 3129 0.0324755783838228 4665 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2570 licareol 100 µM -1.84780902522288 0.0622369571180172 no 3130 0.0323149874164117 4608 443158 SGTC_1432 4049-0298 68.4 µM -1.85100131804502 0.0619126690852521 no 3131 0.0320846817431657 4678 741646 SGTC_2319 6033012 152.6 µM -1.85609177294124 0.061398286776433 no 3132 0.031720239102547 4597 847246 SGTC_587 k089-0003 57 µM -1.86034948427981 0.0609706209260306 no 3133 0.0314180483594209 4590 9659696 SGTC_2220 6782180 200 µM -1.86183969956183 0.0608214876347989 no 3134 0.0313128443904129 4622 833803 SGTC_3187 9109394 49.47 µM -1.86817343463227 0.0601908194927364 no 3135 0.0308689501835625 4638 17098090 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.87145569847536 0.0598660150815092 no 3136 0.030640972444152 4650 5393153 SGTC_1036 k216-0215 33.5 µM -1.87337101324342 0.0596771157215937 no 3137 0.0305085849452227 4604 622330 SGTC_176 1486-1328 72.834 µM -1.87402239937611 0.059612978809429 no 3138 0.0304636689289183 4658 22310231 SGTC_2356 9061756 188.97 µM -1.87906738630794 0.0591180659694141 no 3139 0.0301176463202884 4665 20104043 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.88565384158294 0.0584767921862013 no 3140 0.029670808410163 4597 17037758 SGTC_1014 4130-3005 69.3 µM -1.88691073037135 0.0583550412857421 no 3141 0.029586166804804 4650 743608 SGTC_93 0109-0045 59.227 µM -1.89010008581038 0.0580469918970039 no 3142 0.0293722878260999 4718 88733 SGTC_2914 7968218 45.32 µM -1.89518458539281 0.0575585409882943 no 3143 0.0290339757958655 4638 2977111 SGTC_3252 9135871 49.47 µM -1.89936743609365 0.0571591371462665 no 3144 0.0287580909618945 4672 17682838 SGTC_2871 9038510 12.99 µM -1.90615389498939 0.0565157695971079 no 3145 0.028315120988633 4615 4945164 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.90740068827983 0.0563981944163852 no 3146 0.0282343601656373 4648 5282309 SGTC_2540 epiandrosterone 100 µM -1.9079524016301 0.0563462282783923 no 3147 0.0281986842717808 4672 441302 A steroid. SGTC_2621 lithochol-11-enic acid 100 µM -1.90842109075953 0.0563021118882177 no 3148 0.0281684065292267 4600 6708711 SGTC_387 norethindrone acetate 66.7 µM -1.90861237269923 0.0562841148829807 no 3149 0.0281560573219 4659 541197 SGTC_1283 0922-0125 16.4 µM -1.92496409958698 0.0547623356643653 no 3150 0.0271169248554353 4658 3360884 SGTC_135 0933-0004 26.348 µM -1.93647583317482 0.0537106387509791 no 3151 0.0264047248062872 4596 21230617 YGL099W LSG1 SGTC_1703 st026983 48.3 µM -1.93932474163826 0.0534528513359124 no 3152 0.0262309040136186 4681 1104023 SGTC_2600 tangeritin 87.95 µM -1.94061467453282 0.053336452889268 no 3153 0.0261525164019434 4607 68077 A bioactive flavone. SGTC_2375 9072683 200 µM -1.94630613508789 0.0528252747724742 no 3154 0.0258089885385004 4695 16798029 SGTC_1758 st042942 75.2445 µM -1.94882654100071 0.0526001498947646 no 3155 0.0256580715214835 4647 669317 SGTC_947 3447-0010 211 µM -1.95033700900017 0.0524655988761083 no 3156 0.0255679821675267 4624 748350 SGTC_429 1112-0049 25.5 µM -1.95259426878945 0.0522650337713433 no 3157 0.0254338454087911 4633 2836170 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.95274657816294 0.0522515225303849 no 3158 0.0254248157517893 4686 65057 A dermal irritant. YDR527W RBA50 SGTC_1545 lovastatin 49.4 µM -1.9556670779589 0.0519929834935015 no 3159 0.0252521926960414 4698 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2724 maprotiline 69.64 µM -1.96436191223536 0.0512292816398815 no 3160 0.0247440682579519 4615 4011 A tricyclic antidepressant. SGTC_1258 0671-0043 57.1 µM -1.965406666061 0.0511381205088042 no 3161 0.0246835942879148 4666 4298767 SGTC_2119 5528445 120.635 µM -1.96962482373826 0.050771372590868 no 3162 0.0244406922479194 4683 791935 SGTC_2885 9057732 51.95 µM -1.97086030214855 0.050664351338955 no 3163 0.0243699284654717 4672 6471414 SGTC_1451 4152-0210 104 µM -1.97287068969685 0.0504905890092874 no 3164 0.0242551483821339 4691 659563 SGTC_3063 1327-0034 4 µM -1.97349013582454 0.0504371446739949 no 3165 0.0242198736544204 4565 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2381 9035592 200 µM -1.97356043507056 0.0504310822716449 no 3166 0.024215873145773 4681 4749657 SGTC_1105 epirubicin 18.1 µM -1.99276196292669 0.0487968176147759 no 3167 0.0231437593567766 4689 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3185 9108267 49.47 µM -1.99295196202605 0.0487808606133619 no 3168 0.0231333537854546 4666 4910486 SGTC_2777 climbazole 1.536 µM -1.9971737259076 0.0484273720485912 no 3169 0.0229031570981951 4476 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2032 5185112 25.99 µM -2.0015635812294 0.0480619847800179 no 3170 0.0226658445795886 4590 5718189 SGTC_476 mead acid 10 µM -2.00303628842678 0.0479399001899565 no 3171 0.0225866967914187 4737 5312531 An omega 9 fatty acid. SGTC_1423 4048-0112 5.59 µM -2.01751755263054 0.0467526086413776 no 3172 0.0218207655824125 4721 X1423 SGTC_1006 4099-6547 255 µM -2.02311795523536 0.0462998158714037 no 3173 0.0215304938918154 4695 3146833 SGTC_298 1391-0729 10 µM -2.02481901251345 0.046162984630757 no 3174 0.0214429760312499 4650 3237558 SGTC_1469 k284-2957 126 µM -2.02511849929477 0.0461389278888763 no 3175 0.0214275988829932 4704 23884841 SGTC_2585 alliin 100 µM -2.03001531774413 0.0457470097554963 no 3176 0.0211774911472571 4660 87310 A garlic compound which reacts with lipids. SGTC_87 0100-0052 35.5 µM -2.03287908817641 0.0455190499894888 no 3177 0.0210323701244145 4689 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_249 wiskostatin 11.211 µM -2.03381055880339 0.0454451009164409 no 3178 0.0209853497666891 4686 2775510 A n-wasp and actin depolymerizer. SGTC_2448 5185112 27.17 µM -2.03573350253362 0.0452927448075914 no 3179 0.0208885614950743 4686 5718189 SGTC_1940 st075990 51.1 µM -2.03714665787295 0.0451810417200073 no 3180 0.0208176737237401 4691 1084979 SGTC_2479 5617353 43.85 µM -2.04109049791431 0.0448704724389188 no 3181 0.020620916346223 4683 2731746 SGTC_1282 0886-0010 32.4 µM -2.04474394081674 0.0445843070705316 no 3182 0.0204400545627952 4701 2836211 YNL267W PIK1 SGTC_3094 9117742 49.47 µM -2.05018812456514 0.0441606067537991 no 3183 0.0201730381982144 4665 17149698 SGTC_1813 st051246 8.6015 µM -2.06398588822048 0.0431013066107327 no 3184 0.0195095272004661 4678 5291959 SGTC_855 0428-0020 25 µM -2.06494999588738 0.0430280627524385 no 3185 0.0194638659225994 4709 6812414 SGTC_1996 st072960 66.8 µM -2.06574642998298 0.0429676330334676 no 3186 0.0194262143652898 4719 1719405 SGTC_539 4859-0462 2.54 µM -2.07249922587977 0.0424580134449184 no 3187 0.019109454182082 4682 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_354 2783-3500 4.88 µM -2.07432073199771 0.0423213885225146 no 3188 0.0190247668161769 4693 6740761 SGTC_367 0335-0881 7.1 µM -2.08014546206197 0.0418868811028693 no 3189 0.0187560963973406 4630 23828853 SGTC_872 0588-0139 234 µM -2.08546612971708 0.0414931385580675 no 3190 0.0185135047694199 4680 2047100 SGTC_1313 1220-0047 237 µM -2.08675062103622 0.0413985338185708 no 3191 0.018455341405031 4708 3528706 SGTC_1951 sophoraflavanone G 9.2 µM -2.09062449472043 0.0411142753089863 no 3192 0.018280869112047 4653 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_736 0958-0254 92.6 µM -2.09401470575213 0.0408668076922256 no 3193 0.0181293351336998 4723 6812352 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.09427667114255 0.0408477359957483 no 3194 0.0181176706249469 4730 16486 A toxic proline analog. SGTC_2082 5219693 150 µM -2.09438380947814 0.0408399381537282 no 3195 0.0181129019296443 4680 2834649 SGTC_1129 3453-1384 223 µM -2.10409208732937 0.0401383388831471 no 3196 0.0176852074744756 4668 1084452 SGTC_3037 9091026 49.47 µM -2.1048454250359 0.0400843084819592 no 3197 0.0176523827907915 4585 25236398 YIL048W NEO1 SGTC_2969 9091408 28.7 µM -2.12077886251064 0.0389553181193984 no 3198 0.016970208149936 4650 4286311 SGTC_1779 st039427 55 µM -2.12146480689142 0.0389073017495321 no 3199 0.0169413532689552 4691 1124498 SGTC_1892 st058411 7.36 µM -2.1229291052841 0.0388049615606214 no 3200 0.0168798965411955 4698 3934738 SGTC_3347 9188721 44.724 µM -2.127861523969 0.0384618457170904 no 3201 0.0166742832530107 4689 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_756 0508-1999 28.3 µM -2.13450923576586 0.0380033246876754 no 3202 0.016400559222545 4713 6753853 SGTC_458 nppb 133 µM -2.13501553582729 0.0379685865452898 no 3203 0.0163798705613218 4723 4549 A chloride channel blocker. SGTC_1047 2043-3044 82 µM -2.16274363745564 0.0361053190648834 no 3204 0.0152804513926254 4686 669592 SGTC_559 1550-0661 158 µM -2.16572574800942 0.0359094657763369 no 3205 0.0151660751374713 4732 5830875 SGTC_2261 9010538 184.68 µM -2.17185968081402 0.0355093491752756 no 3206 0.0149331242276168 4696 6457250 SGTC_1085 doxorubicin 7.67 µM -2.17966309327254 0.035005622799004 no 3207 0.0146412221061637 4739 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_347 4534-1311 26.2 µM -2.19799111379225 0.0338455483068752 no 3208 0.0139748695962742 4717 2862016 SGTC_811 0416-0114 265 µM -2.20934942067152 0.0331426291385829 no 3209 0.0135751730956271 4720 6612453 SGTC_1157 4092-0394 27.6 µM -2.21078566510567 0.0330546085743745 no 3210 0.0135253414875777 4742 3659885 SGTC_2766 oltipraz 83.91 µM -2.21280862367629 0.032930957904035 no 3211 0.0134554212461497 4710 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2182 6325192 200 µM -2.21404243142399 0.0328557303731468 no 3212 0.0134129300957902 4737 736248 SGTC_414 piperonyl butoxide 100 µM -2.2150747393571 0.0327928975537245 no 3213 0.0133774674801014 4730 5794 A potent inhibitor of cytochrome P450. SGTC_1774 st048371 48.465 µM -2.21731665791347 0.0326567812990543 no 3214 0.0133007301820334 4724 4242727 SGTC_2355 9061122 103.12 µM -2.21738169792208 0.0326528394129963 no 3215 0.013298509653209 4730 5302957 SGTC_473 2-arachidonoylglycerol 10 µM -2.21924208109582 0.0325402530167597 no 3216 0.0132351298046061 4623 5282280 An endocannabinoid. SGTC_3272 9137413 49.47 µM -2.22559202972776 0.0321583770062726 no 3217 0.0130207602742699 4696 17614870 SGTC_355 1311-2252 105 µM -2.23169710980508 0.0317947227432559 no 3218 0.0128174942020801 4698 5338538 SGTC_2627 acetyl isogambogic acid 100 µM -2.2351391741665 0.0315911953247211 no 3219 0.0127041066276292 4710 6857789 A caspase activator and apoptosis inducer. SGTC_1450 4112-4260 37.6 µM -2.25111230199002 0.0306607564603631 no 3220 0.0121892127249761 4721 1633175 SGTC_743 1275-0778 158 µM -2.25338532032558 0.0305302157461534 no 3221 0.0121174321511195 4731 2849257 YMR203W TOM40 SGTC_2340 7987427 183.45 µM -2.25526847041765 0.0304224143869347 no 3222 0.0120582412147177 4701 2239331 SGTC_411 enrofloxacin 100 µM -2.26054833251378 0.030121848012206 no 3223 0.0118936201409146 4754 71188 A bacterial gyrase inhibitor. SGTC_2517 totarol 10 µM -2.26335809242728 0.0299629032642298 no 3224 0.0118068119509344 4740 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1896 st058441 89 µM -2.26432181503968 0.0299085470849146 no 3225 0.0117771644017124 4742 688759 SGTC_2469 5655019 90.81 µM -2.26551641616124 0.0298412823746656 no 3226 0.0117405038962041 4759 2788239 SGTC_2748 diazoxide 86.69 µM -2.26657519835215 0.029781770201593 no 3227 0.0117080943015655 4782 3019 A potassium channel activatior. SGTC_2164 5685496 200 µM -2.28805020168836 0.0285957975129126 no 3228 0.0110672988879325 4715 759046 SGTC_2749 bexarotene 57.39 µM -2.29013110012962 0.0284829956213829 no 3229 0.0110068590020019 4712 82146 An retinoic acid receptor inhibitor. SGTC_1458 k015-0034 6.33 µM -2.2917515717655 0.0283954092715642 no 3230 0.010959991320302 4746 3598957 SGTC_1842 st055362 61.2 µM -2.29648284004449 0.0281409661736917 no 3231 0.0108241446064153 4738 676032 SGTC_1427 4048-4900 550 nM -2.29685270774286 0.0281211552937542 no 3232 0.0108135868010749 4739 24132586 SGTC_183 3914-0051 30.55 µM -2.29781746548617 0.0280695355111476 no 3233 0.0107860901447467 4723 1596232 SGTC_3315 9136395 68.55 µM -2.29927151440016 0.0279918850821777 no 3234 0.010744763156437 4748 16876844 SGTC_294 k038-0071 157 µM -2.30828118807169 0.0275147212316935 no 3235 0.01049175102736 4760 24152826 SGTC_161 4065-0411 162.148 µM -2.31475219035606 0.0271762090376824 no 3236 0.0103132488801742 4727 1906281 YLR208W SEC13 SGTC_2723 salbutamol 83.58 µM -2.31990594680126 0.0269090969067887 no 3237 0.0101729829065687 4741 9884233 β2-adrenoceptor agonist SGTC_139 0099-0334 718.624 µM -2.33589857447518 0.0260941375436138 no 3238 0.00974826414315424 4723 97690 SGTC_2366 9070441 60.58 µM -2.33649247505048 0.0260642752186299 no 3239 0.00973279466871578 4729 6837235 SGTC_467 ro 31-8220 72.8 µM -2.34062138324785 0.025857455882268 no 3240 0.00962583961604421 4726 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_327 1273-0057 3.96 µM -2.34269286016592 0.0257542128241917 no 3241 0.00957256817621766 4704 3108138 SGTC_3044 9093193 49.47 µM -2.35605762262757 0.0250963708971971 no 3242 0.00923502617679365 4714 25236277 SGTC_207 4185-0010 4.486 µM -2.36725186529727 0.024556260202538 no 3243 0.00896036625634542 4746 3761753 SGTC_1128 3448-9350 235 µM -2.37281971678876 0.0242912707114378 no 3244 0.00882643895370347 4696 619386 SGTC_1837 st055472 66.5 µM -2.40801176077212 0.0226713676264947 no 3245 0.00801983215467097 4763 676091 SGTC_753 1322-0200 289 µM -2.41325473498282 0.0224380057871033 no 3246 0.00790538251898994 4760 5403907 SGTC_757 1066-0008 322 µM -2.41658975065853 0.0222906227798542 no 3247 0.00783333170317479 4748 6842497 SGTC_3341 9147222 25.867 µM -2.41917696967653 0.0221768501619598 no 3248 0.0077778351071312 4761 1939759 SGTC_727 3032-0951 202 µM -2.44810516009731 0.0209377683465942 no 3249 0.00718048670842645 4773 3652836 SGTC_1487 3970-0795 2.82 µM -2.46134039014658 0.0203907026962128 no 3250 0.00692094856173019 4777 3765103 SGTC_92 0063-0024 660.874 µM -2.46140023642313 0.0203882567872319 no 3251 0.00691979406008481 4785 3594437 SGTC_3039 9090270 49.47 µM -2.46470881173605 0.0202534221114094 no 3252 0.00685623192453229 4752 17173750 SGTC_2426 5582046 32.21 µM -2.47164777270548 0.0199730920213319 no 3253 0.00672459771089045 4745 2251934 SGTC_2690 usnic acid 100 µM -2.47865421505696 0.0196933826754371 no 3254 0.00659395436343798 4738 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_22 0964-0034 14.468 µM -2.47883764179827 0.0196861048604435 no 3255 0.0065905645118434 4762 138402 SGTC_3059 1327-0034 3 µM -2.48885264689924 0.0192921912124069 no 3256 0.00640780347723877 4673 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3253 9135987 49.47 µM -2.49324882485098 0.0191214063689148 no 3257 0.00632900532331758 4766 4182430 SGTC_1724 st037281 8.293 µM -2.51738632012127 0.0182064371731598 no 3258 0.00591145577549159 4731 574124 YDL195W SEC31 SGTC_3018 9082602 49.47 µM -2.52316764405747 0.0179929108559472 no 3259 0.00581514705435284 4667 17332089 SGTC_128 0906-2981 13.371 µM -2.53111408706713 0.0177029055843216 no 3260 0.00568504296088543 4760 6740226 SGTC_687 k029-0044 34.9 µM -2.53707549202026 0.0174879712398484 no 3261 0.00558914231120692 4775 5829338 SGTC_1024 4507-0395 26 µM -2.5382373758606 0.0174463407792661 no 3262 0.00557061937699308 4765 4201836 SGTC_2858 9025781 8.96 µM -2.55246925767203 0.0169432386626341 no 3263 0.00534811742482956 4631 4894980 YPL153C RAD53 SGTC_1522 st012842 45.6 µM -2.57486624980578 0.0161766298891407 no 3264 0.00501394279402283 4674 3491067 YOR116C RPO31 SGTC_122 0236-0016 402.397 µM -2.60405795589478 0.0152222104163807 no 3265 0.0046063588358945 4759 6808838 SGTC_1394 3474-0001 65.7 µM -2.60724549580118 0.0151209843352184 no 3266 0.00456369472090264 4768 5017666 YIL048W NEO1 SGTC_2684 capsaicin 100 µM -2.62010850053757 0.0147183516393818 no 3267 0.00439508974431183 4787 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2099 5377090 177.372 µM -2.63331783765921 0.0143145109194326 no 3268 0.00422775897003329 4777 2243829 SGTC_1772 st048439 82.2 µM -2.64404372046106 0.0139936507960274 no 3269 0.00409610369226435 4782 2927068 YDL195W SEC31 SGTC_3108 9121785 49.47 µM -2.65842903770512 0.0135730666611747 no 3270 0.00392529407085666 4726 17140271 SGTC_2033 5192550 145 µM -2.67220830301438 0.0131804772587352 no 3271 0.00376769281040809 4770 182073 SGTC_794 k038-0031 316 µM -2.67503861895984 0.0131010638597886 no 3272 0.0037360321175264 4765 6624242 SGTC_2190 6049624 200 µM -2.67629597490938 0.0130659176641279 no 3273 0.00372204368873539 4750 2265554 SGTC_2938 9059746 27.26 µM -2.68295963219399 0.0128810094114181 no 3274 0.00364868990606068 4754 6471769 SGTC_3335 9143315 29.6265 µM -2.68647854332082 0.0127842802585533 no 3275 0.00361047929470074 4769 4899691 SGTC_1471 k673-0312 37 µM -2.69784120781327 0.0124762173866988 no 3276 0.00348953610921513 4793 24099884 SGTC_657 3534-0529 86.7 µM -2.69892898031137 0.0124470658221555 no 3277 0.00347815098029552 4785 1049549 SGTC_1649 st011737 51.3 µM -2.6995038192978 0.0124316843634397 no 3278 0.00347214793466917 4768 1761035 SGTC_1223 0764-0573 147 µM -2.71858872836287 0.0119302745564382 no 3279 0.00327805346282217 4786 1609797 SGTC_676 falcarinol 140 µM -2.72423734029244 0.0117852761196384 no 3280 0.00322250862132611 4772 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2595 hexamethylquercetagetin 100 µM -2.74350491929708 0.0113021267257494 no 3281 0.00303935687092942 4746 386331 SGTC_1879 gemcitabine 100 µM -2.75368783031297 0.0110538053707554 no 3282 0.00294639727241702 4771 60750 A nucleoside analog which inhibits DNA replication. SGTC_2145 5634607 200 µM -2.76328788385608 0.0108240573112144 no 3283 0.00286111358722201 4790 308662 SGTC_163 TUB2.036 7.546 µM -2.78972639639045 0.0102126909213659 no 3284 0.0026376300093104 4740 15992207 YJR013W GPI14 SGTC_2701 st077767 14.721 µM -2.801517436295 0.00994989106808181 no 3285 0.00254314462210857 4771 5721188 SGTC_349 k015-0014 24 µM -2.80534200490046 0.00986592624008658 no 3286 0.00251316081403306 4781 2196908 SGTC_314 1671-0008 2.74 µM -2.81076651429406 0.00974789761522398 no 3287 0.00247118186471616 4704 3913060 SGTC_1484 3473-2379 286 µM -2.82227496412179 0.0095015699384515 no 3288 0.00238421371121553 4795 671917 SGTC_1629 st005085 44.9 µM -2.84646280876893 0.00900152954241031 no 3289 0.0022103946426635 4766 24207091 SGTC_2363 9053361 176 µM -2.85019921097743 0.00892637778332995 no 3290 0.0021845927129415 4775 6469797 YMR079W SEC14 SGTC_3337 9144342 33.5465 µM -2.86451589990478 0.00864348543244462 no 3291 0.00208823593435089 4779 17682949 SGTC_299 1273-0059 1.44 µM -2.87616702469253 0.0084190982147736 no 3292 0.00201268323947966 4628 2848077 SGTC_120 rhodamine 6G 52.259 µM -2.88393083166987 0.00827243019179792 no 3293 0.00196372503541438 4781 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2127 5253358 187.912 µM -2.90792169547496 0.00783329855006445 no 3294 0.00181919714625199 4769 20612 SGTC_1321 1326-2144 215 µM -2.91267375067817 0.00774879151203075 no 3295 0.00179174389634578 4779 3513030 SGTC_781 4335-2806 94.4 µM -2.9211855533402 0.00759942790620601 no 3296 0.00174351039330191 4793 845254 SGTC_2616 abietic acid 100 µM -2.93764970075333 0.00731769724658207 no 3297 0.00165355232193077 4782 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_309 k408-0051 1.48 µM -2.96465293570247 0.00687552904262951 no 3298 0.0015151229048363 4744 3640463 SGTC_1991 st073000 8.92 µM -2.99260791247164 0.00644279840398202 no 3299 0.00138302429376175 4792 4301969 YIL048W NEO1 SGTC_3263 9137018 49.47 µM -3.00379867648269 0.00627643940762231 no 3300 0.00133315847705699 4779 43844957 SGTC_769 0302-0231 76 µM -3.01514807302922 0.00611161795717316 no 3301 0.00128426912785411 4756 571869 YER009W NTF2 SGTC_2048 5246248 200 µM -3.02441066600075 0.00597995624796375 no 3302 0.00124559015646582 4798 677046 SGTC_942 3253-1115 227 µM -3.05380548991251 0.00557862666053421 no 3303 0.00112979266725462 4785 46497897 SGTC_1607 st000305 50.6 µM -3.05793174994399 0.00552424877859657 no 3304 0.00111435164755227 4795 5457690 SGTC_3028 9087778 49.47 µM -3.08497911097135 0.00517932075592732 no 3305 0.00101783224886684 4781 17217395 SGTC_2974 9094440 9.66 µM -3.08770969071308 0.00514558657907439 no 3306 0.00100852705745864 4772 25236134 SGTC_1383 3049-0032 20.7 µM -3.10406358570238 0.00494760952007771 no 3307 0.000954411513557752 4795 712864 SGTC_2860 9025725 38.96 µM -3.10889757718012 0.00489040420381056 no 3308 0.000938934020840791 4797 40546248 SGTC_266 formosanin C 406 nM -3.13214427114864 0.0046234555621993 no 3309 0.000867672893060148 4753 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2893 9048488 25.97 µM -3.1381877721485 0.00455622124300021 no 3310 0.000849979688008904 4789 6467338 SGTC_2468 5987765 72.9 µM -3.18015236185524 0.00411294731842218 no 3311 0.000735988181002504 4799 26772094 SGTC_2651 TUB2.036 5 µM -3.19018167560256 0.00401289568766468 no 3312 0.00071091690557803 4723 15992207 YFL037W TUB2 SGTC_1395 3486-0190 4.35 µM -3.23028268799682 0.00363427590246007 no 3313 0.000618339383006894 4797 6748079 SGTC_2700 st077718 96.8 µM -3.24033546848919 0.00354453310373776 no 3314 0.000596945747837732 4788 904970 SGTC_1696 st025591 34.7925 µM -3.25630143325225 0.00340608664548622 no 3315 0.000564369251148662 4803 2787147 SGTC_304 1310-0298 97 µM -3.27080182749805 0.00328458017413723 no 3316 0.000536215164751662 4688 1550234 SGTC_178 4092-0806 87.505 µM -3.2912596198126 0.00311978121699503 no 3317 0.000498699087331166 4755 2169044 SGTC_3109 9122853 49.47 µM -3.29804462549729 0.00306679110745543 no 3318 0.000486803298291689 4805 1234709 SGTC_1049 3226-0134 66 µM -3.35862600070484 0.00262840414373881 no 3319 0.000391655009275833 4794 5702385 SGTC_310 1273-0058 1.06 µM -3.41407369397125 0.0022776576141608 no 3320 0.000319996312260298 4561 2734232 SGTC_2279 7948423 32.93 µM -3.42609687754452 0.00220743589421663 no 3321 0.000306160971488842 4790 1247112 SGTC_3152 9099253 49.47 µM -3.43315203089377 0.00216714937973536 no 3322 0.000298303731179201 4721 25236131 SGTC_3266 9136860 49.47 µM -3.43417990612144 0.00216133594059064 no 3323 0.000297174790190745 4690 4871271 YPR165W RHO1 SGTC_1953 st076800 12.1 µM -3.4369118144568 0.00214595352527494 no 3324 0.000294193569587515 4790 297591 SGTC_1019 4262-0212 3.4 µM -3.59505429967291 0.00140775854595159 no 3325 0.000162161962598821 4789 4677213 SGTC_1712 st032288 53.4 µM -3.61864532363989 0.00132013886330001 no 3326 0.000148074591560915 4749 2883011 SGTC_1941 st076221 61.8 µM -3.66511278730155 0.00116196913678063 no 3327 0.000123614802356417 4777 2828568 SGTC_1648 st011736 69.8 µM -3.72574681082844 0.000981672958917954 yes 3328 9.73689002044897e-05 4809 2855514 SGTC_1713 st033146 12.748 µM -3.73355650153212 0.000960418386942244 yes 3329 9.43974082249693e-05 4796 674619 SGTC_2896 9052656 71.43 µM -3.73898420019484 0.000945896362947905 yes 3330 9.23826689168104e-05 4599 6469436 SGTC_1250 0485-0349 40.2 µM -3.76173981607614 0.000887181728932327 yes 3331 8.43677635018995e-05 4792 6842794 YDL195W SEC31 SGTC_1910 st062352 60.4 µM -3.78724159537482 0.000825374374347435 yes 3332 7.61644853805249e-05 4792 2245730 SGTC_2484 5809818 12.04 µM -3.81763529495343 0.000756895296354538 yes 3333 6.73684511212169e-05 4800 2870548 SGTC_2940 9060638 45.86 µM -3.91363257259042 0.00057349664367472 yes 3334 4.54589734691225e-05 4795 4027022 SGTC_3219 9131112 49.47 µM -3.94144360457206 0.000528612082762196 yes 3335 4.04963395252068e-05 4776 17612988 YMR079W SEC14 SGTC_893 0958-0369 48.9 µM -3.9891863584615 0.00045906133037809 yes 3336 3.31501598144015e-05 4760 6819948 SGTC_1949 st076024 69.1 µM -4.34805089503047 0.000151635819004994 yes 3337 6.86763673837334e-06 4796 2921930 SGTC_1917 st066507 28.5 µM -4.36958071479233 0.000141508778914724 yes 3338 6.22426611364482e-06 4747 3156428 SGTC_2163 5671233 125 µM -4.63581662814412 5.87095595341543e-05 yes 3339 1.77765522458094e-06 4809 701023 SGTC_2250 alverine citrate 130 µM -4.67954465783555 5.05857331794143e-05 yes 3340 1.43756366146463e-06 4786 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_274 sirtinol 40.1 µM -4.72556396311646 4.31886671527898e-05 yes 3341 1.14738792953918e-06 4806 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1263 0774-1208 64.8 µM -4.89926832752825 2.34837887760003e-05 yes 3342 4.80970999621458e-07 4806 906585 SGTC_952 1185-0122 232 µM -5.17863477560525 8.45496953036108e-06 yes 3343 1.11757783639812e-07 4794 678600 SGTC_58 0957-0393 9 µM -5.40359535004726 3.57750872618706e-06 yes 3344 3.26591040560288e-08 4709 6997992 SGTC_40 0327-0103 19.753 µM -5.97871154846404 3.40673123686767e-07 yes 3345 1.1245470058859e-09 4803 409036 SGTC_1909 st060837 51.5 µM -6.01277785223557 2.9433808422938e-07 yes 3346 9.11854378239243e-10 4809 678937 SGTC_453 enantio-paf c16 10 µM -6.59780379309635 2.11814684432946e-08 yes 3347 2.0864650341823e-11 4742 13871343 A lipid and platelet activating factor SGTC_3143 9086658 49.47 µM -6.62506357440938 1.86327271996761e-08 yes 3348 1.73549380552569e-11 4808 25236626