SGTCid condition conc unit URK1|YNR012W.score URK1|YNR012W.strain.pval URK1|YNR012W.strain.significant URK1|YNR012W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1175 0741-0056 27.6 µM 7.51569931685554 1.28903040196663e-13 yes 1 2.83037606527599e-14 1 765927 SGTC_1745 st081495 74 µM 7.31066753734155 5.61936608404967e-13 yes 2 1.32909243391513e-13 16 13842402 YBL026W LSM2 SGTC_2192 5915882 198.485 µM 7.09108895456949 2.60307906999077e-12 yes 3 6.65303884136509e-13 7 2876149 SGTC_1261 0712-0010 12.7 µM 6.87805699456882 1.10327534053838e-11 yes 4 3.03371986194801e-12 2 2840123 SGTC_2584 androsterone 48.74 µM 5.99470825282481 2.79759118458078e-09 yes 5 1.01925539379987e-09 59 2754130 A steroid. SGTC_3351 9150312 21.596 µM 5.72117628525318 1.34019739230407e-08 yes 6 5.28945310263548e-09 9 4904905 SGTC_2367 9070478 135.38 µM 5.60754801098713 2.51727781396249e-08 yes 7 1.02606548676194e-08 13 572802 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 5.18184068944808 2.40082203251354e-07 yes 8 1.09853418323575e-07 1 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_957 1187-1561 14.1 µM 5.15921139376038 2.6939203123964e-07 yes 9 1.23996090227851e-07 7 1538454 SGTC_453 enantio-paf c16 10 µM 4.97553297236151 6.74264549003724e-07 yes 10 3.25341784473684e-07 88 13871343 A lipid and platelet activating factor SGTC_2970 9090938 41.86 µM 4.84258462401838 1.28469634529925e-06 yes 11 6.40805121200282e-07 13 17217104 SGTC_1351 1496-0003 46.5 µM 4.76944413223178 1.81890657271419e-06 yes 12 9.23674831643519e-07 10 3891978 SGTC_2569 tetrandrine 100 µM 4.68032212287299 2.76012776715077e-06 yes 13 1.43212263528934e-06 10 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3341 9147222 25.867 µM 4.58809536978319 4.21717797948208e-06 yes 14 2.23654147457693e-06 4 1939759 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 4.48171146262157 6.81028535500017e-06 yes 15 3.70234062671866e-06 9 75037 A free radical scavenger. SGTC_2363 9053361 176 µM 4.06401492950467 4.04519236240587e-05 yes 16 2.41178692604207e-05 28 6469797 YMR079W SEC14 SGTC_2378 9074213 121.43 µM 4.00257879590923 5.18708273543014e-05 yes 17 3.13278952618073e-05 18 657714 SGTC_1851 st056236 18.9 µM 3.88139461006624 8.38611510794669e-05 yes 18 5.19295794415504e-05 16 5393171 SGTC_1489 4065-0444 182 µM 3.86640233601073 8.89140496572333e-05 yes 19 5.52263330780969e-05 22 2877968 SGTC_2390 9097792 176.6 µM 3.68309226009168 0.00017885914398625 yes 20 0.00011521085836186 20 4497149 SGTC_2416 tofa 880 nM 3.57935366166808 0.000262091973049242 yes 21 0.000172222532266703 66 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1024 4507-0395 26 µM 3.56954902242417 0.000271593728642734 yes 22 0.000178798149067904 35 4201836 SGTC_309 k408-0051 1.48 µM 3.5461777867923 0.000295552403852578 yes 23 0.000195431205617178 77 3640463 SGTC_1259 0671-0132 43 µM 3.53529586048138 0.000307366508045012 yes 24 0.000203659414158981 39 X1259 SGTC_1506 4226-2149 212 µM 3.49891931390316 0.000350124949241357 yes 25 0.000233573960741685 46 991114 SGTC_1633 st005664 67.9 µM 3.47521251806582 0.000380899124352631 yes 26 0.000255224393680707 53 2063822 SGTC_1373 2887-0003 58.5 µM 3.47275192620732 0.000384233191165726 yes 27 0.00025757563923791 35 776948 SGTC_34 0469-0683 81.75 µM 3.44239657520577 0.000427655110252034 yes 28 0.000288292147783324 44 3690923 SGTC_1255 0566-0045 221 µM 3.39925133733766 0.000497240835674424 yes 29 0.000337852957181839 47 2788469 SGTC_1638 st008370 60.6 µM 3.38825386624026 0.000516582475533474 yes 30 0.000351695639376052 48 24207134 SGTC_2387 9077560 195.08 µM 3.37947481491444 0.000532519722506471 yes 31 0.000363122305071992 33 5303272 SGTC_270 tamoxifen 5.46 µM 3.28068699454081 0.000746040730509018 yes 32 0.000517772974373516 63 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1843 st055809 45.5 µM 3.28030378770478 0.000747004414660742 yes 33 0.000518476825372932 39 16413835 SGTC_87 0100-0052 35.5 µM 3.26551305395149 0.00078508819245056 yes 34 0.000546329845166746 178 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3010 9080089 71.4286 µM 3.24520513323583 0.000840293548976014 yes 35 0.000586830220232949 43 17027233 SGTC_1792 st045773 43.6 µM 3.22806497710347 0.000889642988416428 yes 36 0.000623153306237416 61 2919270 SGTC_722 3534-0461 190 µM 3.21962024417156 0.000914924085560281 yes 37 0.000641802576039082 69 658262 SGTC_1437 4092-1038 11.6 µM 3.19798453815681 0.0009827370833025 yes 38 0.000691958501808953 42 3977136 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 3.16845231979695 0.00108275657419003 no 39 0.00076626442185445 70 688664 SGTC_2064 5220758 200 µM 3.16039497687869 0.00111162108209039 no 40 0.000787776971169663 76 788518 SGTC_995 3931-2021 34.6 µM 3.14434839526155 0.00117121709084201 no 41 0.000832285678985137 52 730143 SGTC_1341 1486-1360 280 µM 3.14225383285127 0.00117920841881452 no 42 0.000838263117178813 64 3976547 SGTC_304 1310-0298 97 µM 3.13021265785918 0.00122612527034626 no 43 0.000873398991402663 107 1550234 SGTC_178 4092-0806 87.505 µM 3.12774236513043 0.00123595912543844 no 44 0.000880772587352697 146 2169044 SGTC_1915 st067105 30.6 µM 3.08129057928971 0.00143483694720692 no 45 0.00103052701498094 94 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_134 0269-0018 6.916 µM 3.06069099603925 0.00153204686724722 no 46 0.00110413433237287 191 4378915 SGTC_349 k015-0014 24 µM 3.02526409289471 0.00171337157285548 no 47 0.00124208056018125 61 2196908 SGTC_3149 9097855 49.47 µM 3.01904070032186 0.00174717175359022 no 48 0.0012678823149736 66 25236625 YMR079W SEC14 SGTC_347 4534-1311 26.2 µM 3.01223665341311 0.0017848190105144 no 49 0.00129665169456597 41 2862016 SGTC_2365 9042475 200 µM 2.9919828931384 0.00190129333394408 no 50 0.00138585897158996 87 6464479 SGTC_2156 5649887 115 µM 2.98894916715855 0.00191932233719537 no 51 0.00139969350397642 53 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2936 9038235 15.59 µM 2.97146686108888 0.00202627775071776 no 52 0.0014819042888134 78 4749415 SGTC_2906 7926292 26.41 µM 2.96905296598642 0.00204146343409013 no 53 0.00149359551118837 78 2966319 SGTC_2049 5262831 67.185 µM 2.93562408678429 0.00226265025165004 no 54 0.00166438722593798 85 763417 SGTC_3252 9135871 49.47 µM 2.90609794015511 0.00247583238467423 no 55 0.00182983440139918 52 17682838 SGTC_310 1273-0058 1.06 µM 2.9016264846558 0.00250965505139995 no 56 0.00185615439949006 366 2734232 SGTC_232 clozapine 119 µM 2.89730677326483 0.00254272608538525 no 57 0.00188190756960413 124 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2561 acetosyringone 100 µM 2.8960827344248 0.00255216849515872 no 58 0.00188926383860025 88 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_566 0958-0068 16.5 µM 2.89364653713607 0.00257105603825443 no 59 0.00190398279591937 55 6815365 SGTC_1371 2421-0008 32.7 µM 2.85403713956093 0.00289638731203494 no 60 0.0021583742233531 111 2827552 SGTC_1787 fluconazole 80 µM 2.83648315604408 0.00305208852818438 no 61 0.00228066921549375 110 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1062 mesoridazine 14.2 µM 2.82126669063917 0.00319311273463727 no 62 0.00239172090088944 73 4078 A neuroleptic. SGTC_1171 0368-0077 21.4 µM 2.82107129209035 0.00319496117993508 no 63 0.00239317823024449 64 3239779 SGTC_2695 st077686 51.995 µM 2.80833793553912 0.00331751290565514 no 64 0.00248989700429291 93 2876092 SGTC_1845 st056753 3.01 µM 2.79223838163208 0.00347850512856726 no 65 0.00261723886801223 93 5375839 SGTC_2324 6149169 200 µM 2.78001234875011 0.00360541414063794 no 66 0.00271784156927544 64 2888231 SGTC_150 3970-0969 77.2 µM 2.76877745236247 0.00372568249397052 no 67 0.00281335273118941 155 6615640 SGTC_736 0958-0254 92.6 µM 2.76502087460601 0.00376669169610865 no 68 0.00284595766238666 105 6812352 SGTC_2443 5493264 126.67 µM 2.7579664669729 0.00384479725569297 no 69 0.00290810819920185 83 5340055 SGTC_2935 9038016 29.96 µM 2.73758370757902 0.00407869290471213 no 70 0.00309461833425697 90 6463195 SGTC_3073 9114972 49.47 µM 2.7374766471266 0.0040799543512127 no 71 0.00309562578123352 69 41905075 SGTC_2312 7706453 155.7 µM 2.72150232588593 0.00427213186227926 no 72 0.00324929638983044 92 976098 SGTC_3199 9111318 49.47 µM 2.70612909097514 0.00446467913166456 no 73 0.00340362892217931 89 8548020 SGTC_500 h-89 112 µM 2.69483290637859 0.00461106392144955 no 74 0.00352119686605704 95 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2092 5303694 80.6725 µM 2.6898703775973 0.00467671552201047 no 75 0.00357398887964055 110 1963699 SGTC_3356 9151811 4.48 µM 2.68900257541698 0.00468828136250952 no 76 0.00358329331463506 83 1859254 YPR165W RHO1 SGTC_312 4092-0653 6.84 µM 2.6809688741379 0.00479656991976381 no 77 0.00367046718421397 176 1148278 SGTC_2248 tofa 1.1 µM 2.67393730940682 0.00489317468279695 no 78 0.0037483232012121 111 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_674 0498-0004 451 µM 2.67344450164584 0.00490000980852418 no 79 0.00375383487946945 86 4231473 SGTC_1632 st005650 90 µM 2.67232330619336 0.00491559222973018 no 80 0.00376640167889448 100 2759605 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.65158583932196 0.00521187322906964 no 81 0.00400573728504841 135 2724 A muscle relaxant with antifungal properties. SGTC_2331 7980721 200 µM 2.64556118530246 0.00530087707116193 no 82 0.0040777768204398 106 2981221 SGTC_2495 cafestol 54.53 µM 2.6025919698585 0.00597583834180509 no 83 0.00462609978099542 117 16667697 An anti-infammatory. SGTC_1534 6-azauridine 81.6 µM 2.60176132485455 0.0059896047841305 no 84 0.00463731871057755 113 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_700 3453-2283 142 µM 2.5853498708074 0.00626742097744443 no 85 0.00486401137480431 123 565664 SGTC_822 1487-0950 154 µM 2.57401047089623 0.0064659836033874 no 86 0.00502636154197521 84 1958375 SGTC_1078 idebenone 36.1 µM 2.55147006101206 0.00687727830144715 no 87 0.00536347699496142 151 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_146 3448-8650 53.125 µM 2.54660184627324 0.00696908449265418 no 88 0.00543887322803408 277 2891488 YIL048W NEO1 SGTC_118 0083-0097 135.343 µM 2.53946821061841 0.00710556679726353 no 89 0.00555105671125016 356 5207356 SGTC_2748 diazoxide 86.69 µM 2.5365621162432 0.00716183943217924 no 90 0.00559734403860098 63 3019 A potassium channel activatior. SGTC_631 k072-0230 41.5 µM 2.52661329331988 0.00735747278788573 no 91 0.00575841179831156 109 5773147 SGTC_3197 9113331 49.47 µM 2.5050891510617 0.00779691337171267 no 92 0.00612102660600507 164 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_272 doxorubicin 8.13 µM 2.50340160751784 0.0078323233445905 no 93 0.00615029384766891 144 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_441 propafenone 146 µM 2.49404958075978 0.00803113427339865 no 94 0.00631474509251125 58 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_966 1300-0360 30.2 µM 2.48091411802282 0.00831786266766218 no 95 0.00655229713264016 125 70588 SGTC_580 1123-0028 41 µM 2.47936721390886 0.00835221406364128 no 96 0.00658078630180159 167 1677248 YPR107C YTH1 SGTC_1468 k284-1086 134 µM 2.46416932455354 0.00869638521899856 no 97 0.00686656087414049 173 15996457 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.46176008110605 0.00875207188772631 no 98 0.00691285583800598 132 1377 SGTC_834 0312-0008 75.7 µM 2.45002277279594 0.0090278597495316 no 99 0.00714235899585011 163 6385573 YIL048W NEO1 SGTC_2858 9025781 8.96 µM 2.43950368737334 0.00928146065554976 no 100 0.00735372628606925 248 4894980 YPL153C RAD53 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.4328567083776 0.00944490535561474 no 101 0.00749011395226232 193 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2330 7979373 200 µM 2.41307760704069 0.0099462390909284 no 102 0.00790922549971895 149 1863007 SGTC_972 1319-0219 195 µM 2.4125571764669 0.00995973813279198 no 103 0.00792052630665812 128 23903702 SGTC_2010 4012422 159 µM 2.40706831946554 0.0101030859975452 no 104 0.00804058059910808 132 952393 SGTC_127 0180-0333 59.125 µM 2.40050153411229 0.0102769476907975 no 105 0.0081863110611329 202 771601 SGTC_773 4358-1457 44.6 µM 2.37355227626672 0.0110180626083347 no 106 0.00880894946212246 175 1186886 SGTC_341 1486-1430 230 µM 2.37322084812463 0.0110274591301013 no 107 0.00881685837725796 146 2054753 YPL210C SRP72 SGTC_1762 st045503 25.4615 µM 2.37120077043574 0.0110848824509796 no 108 0.00886519847712762 144 4645554 SGTC_358 0075-0058 9.45 µM 2.37052961549663 0.0111040183676055 no 109 0.00888131041838391 237 1069125 SGTC_3101 9120531 49.47 µM 2.36403107008512 0.0112907950640355 no 110 0.00903864822138768 159 24824904 SGTC_2381 9035592 200 µM 2.36356047677823 0.0113044259427724 no 111 0.00905013607803274 128 4749657 SGTC_2688 kanamycin b 96.69 µM 2.3623657337741 0.0113390963022866 no 112 0.00907935892409924 681 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2247 cerulenin 830 nM 2.36045483722246 0.0113947408810162 no 113 0.0091262703235468 127 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1074 carmofur 3.8 µM 2.3527479281256 0.0116215779844377 no 114 0.00931763103498633 164 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_833 3852-0053 558 µM 2.34594875393779 0.0118249426411041 no 115 0.00948935834282414 143 3123681 SGTC_781 4335-2806 94.4 µM 2.33703751134272 0.0120961501752333 no 116 0.00971861685130514 141 845254 SGTC_2313 7726885 200 µM 2.33303371555838 0.0122197482349085 no 117 0.00982318791952015 157 726423 SGTC_749 1000-0129 128 µM 2.3313637638814 0.0122716225678167 no 118 0.00986709328226807 146 708470 SGTC_911 3456-4043 236 µM 2.32463816483491 0.0124824786833483 no 119 0.0100456581303003 164 914281 SGTC_1005 4092-0690 4.4 µM 2.31815718673131 0.0126886264617805 no 120 0.0102203899401342 143 1529343 SGTC_1510 1123-0200 71.5 µM 2.3180393045079 0.012692403193983 no 121 0.0102235925233863 193 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3324 9138759 60.749 µM 2.31633424568814 0.0127471390667654 no 122 0.0102700129507958 133 45595710 SGTC_1996 st072960 66.8 µM 2.30622270374645 0.0130759551589085 no 123 0.0105490957996942 131 1719405 SGTC_570 0987-0065 62.6 µM 2.30393818171991 0.0131512524618488 no 124 0.0106130569954871 88 3104428 SGTC_3331 9141060 1.957 µM 2.30311593963016 0.0131784449151132 no 125 0.0106361603539103 139 4906567 YPR165W RHO1 SGTC_2172 5754775 163.918 µM 2.30116803291176 0.013243058287906 no 126 0.0106910675206299 158 2263357 SGTC_1012 4112-3522 18 µM 2.29557283243587 0.0134301791542241 no 127 0.0108501588095268 148 3112398 SGTC_1721 st082152 9.2685 µM 2.29336758609065 0.0135045542031156 no 128 0.0109134255689205 149 5296051 SGTC_2845 9003024 42.97 µM 2.28983938109443 0.0136242873941469 no 129 0.0110153146651468 207 2990173 SGTC_1993 st073995 70.8 µM 2.27141025046658 0.0142646971487749 no 130 0.0115610772315996 142 3098394 SGTC_1478 0453-0656 35.7 µM 2.26583430562479 0.0144634999023034 no 131 0.0117307650486748 131 5258496 SGTC_3 0833-0587 95.581 µM 2.25368902961999 0.014904793343977 no 132 0.012107868997411 134 5382644 SGTC_2659 sanguinarine 24.21 µM 2.24875424834351 0.0150873765542868 no 133 0.012264067834218 144 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1246 0422-0085 105 µM 2.22009993872904 0.0161859849335655 no 134 0.01320599218678 207 264295 SGTC_1695 st026914 34.495 µM 2.21283884106666 0.0164750227518929 no 135 0.013454379201669 169 3289191 SGTC_1623 st003709 20.3 µM 2.20313167926129 0.0168683229593533 no 136 0.0137927344754991 274 16192618 SGTC_2722 naftopidil 47.16 µM 2.19419663589917 0.017237408974784 no 137 0.0141106381614352 151 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3077 9117319 49.47 µM 2.18982283026706 0.0174205819904351 no 138 0.0142685441627859 129 17154678 SGTC_2623 humulene 100 µM 2.17575314763967 0.0180211281384457 no 139 0.0147868618799336 131 6187145 An anti-inflammatory. SGTC_2444 5485484 36.41 µM 2.17324515233048 0.0181300116988152 no 140 0.0148809355499343 214 6790631 SGTC_2777 climbazole 1.536 µM 2.16555527551676 0.0184673663776345 no 141 0.0151725935835009 220 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2304 7443016 91.4 µM 2.16053362369226 0.0186905394670174 no 142 0.0153656917885366 139 939854 SGTC_3321 9137793 26.8275 µM 2.15691113440094 0.0188529523601261 no 143 0.015506294607843 234 4904192 SGTC_2952 9073731 13.78 µM 2.15269346562648 0.0190435612290083 no 144 0.0156713886926434 219 16457353 SGTC_3020 9089140 49.47 µM 2.15247267849775 0.0190535842260842 no 145 0.015680072443416 167 17217859 SGTC_956 1185-0240 191 µM 2.13781935856917 0.0197288988104354 no 146 0.0162657036045666 180 1416193 SGTC_2041 5107442 45.335 µM 2.13641407159957 0.0197947178887921 no 147 0.0163228390476226 215 793005 SGTC_335 4077-0256 27.6 µM 2.13259915348147 0.0199743366830715 no 148 0.016478811415735 183 3121989 SGTC_2896 9052656 71.43 µM 2.12780301573007 0.0202021147877688 no 149 0.0166767096173097 371 6469436 SGTC_2025 5147754 141 µM 2.12753586030654 0.0202148670255268 no 150 0.0166877925181772 140 315777 YLR208W SEC13 SGTC_792 4534-1957 155 µM 2.12508062334491 0.0203323837642332 no 151 0.0167899430511926 193 1717904 SGTC_740 k014-0057 261 µM 2.11550194095711 0.0207964066736674 no 152 0.0171935948384191 210 4012779 SGTC_2863 9028737 58.44 µM 2.11470486979076 0.0208354203347949 no 153 0.0172275545313265 122 6460917 SGTC_188 3229-0966 278.469 µM 2.1136119786145 0.020889013991671 no 154 0.0172742109559318 224 5722370 SGTC_3155 9099265 49.47 µM 2.09193692095724 0.0219762728233002 no 155 0.0182220793925119 183 25236499 SGTC_210 3551-0445 56.827 µM 2.08367098526775 0.02240330774562 no 156 0.0185950525938852 217 2865180 YOR207C RET1 SGTC_539 4859-0462 2.54 µM 2.07977051135047 0.0226072319895439 no 157 0.0187732935435909 193 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2151 5563267 85.4165 µM 2.07692615670333 0.0227569250094986 no 158 0.0189041875874334 211 5310824 SGTC_1997 st073024 93.8 µM 2.0751043861643 0.0228532395092112 no 159 0.0189884306608921 166 686268 SGTC_1462 k081-0014 26.5 µM 2.07420747368958 0.0229007840636416 no 160 0.019030023218412 119 3270634 SGTC_788 1182-0090 188 µM 2.07383860334469 0.0229203617296047 no 161 0.0190471513274406 307 5715185 SGTC_3347 9188721 44.724 µM 2.06429802756683 0.0234316439633608 no 162 0.0194947339625339 170 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2071 5230951 39.92 µM 2.05442279174879 0.0239709338780354 no 163 0.0199673945029048 202 1799272 SGTC_2171 5739187 198.077 µM 2.05423161966345 0.0239814759115063 no 164 0.0199766397106016 159 2262761 SGTC_340 k038-0059 454 µM 2.05174923876405 0.0241187189535062 no 165 0.0200970194040627 217 23733424 SGTC_1679 SEC14.276 6.7 µM 2.05127482090281 0.0241450229849407 no 166 0.0201200955442117 258 1005053 YMR079W SEC14 SGTC_168 3970-0862 530.542 µM 2.0486186181726 0.0242927413184715 no 167 0.0202497113154992 434 3135186 SGTC_3148 9097893 49.47 µM 2.03648287223325 0.0249773302244031 no 168 0.0208509456370393 224 17174100 SGTC_629 3448-6466 76.7 µM 2.03560478121665 0.0250274855298271 no 169 0.0208950286532128 220 573744 SGTC_1218 1348-1416 30.7 µM 2.03373959644211 0.0251343024064987 no 170 0.0209889287921582 202 6787668 SGTC_955 1216-0110 33 µM 2.03063011625611 0.0253132279598367 no 171 0.0211462651516729 299 3619719 SGTC_1409 3909-8004 61.9 µM 2.03021186141003 0.02533737638459 no 172 0.0211675043344497 254 2119279 SGTC_1148 3909-7663 27.7 µM 2.02178176732628 0.025828226980784 no 173 0.0215994510882588 192 4084526 SGTC_2481 5478948 45.16 µM 2.02004002945185 0.0259306270614533 no 174 0.0216896177810343 236 77792 SGTC_1727 st034309 9.9045 µM 2.01544282312628 0.026202538044386 no 175 0.0219291356484656 294 870305 SGTC_1494 4358-1428 177 µM 2.01246147614024 0.0263801470005154 no 176 0.0220856568469209 216 1564571 SGTC_779 1360-0071 233 µM 2.01236460862017 0.0263859345634795 no 177 0.0220907581836749 227 7566 SGTC_433 pimozide 108 µM 2.01223519287682 0.0263936684475612 no 178 0.0220975751602935 158 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1155 4088-0394 48.2 µM 2.00296073930699 0.0269528632329679 no 179 0.0225907513546964 218 2326248 SGTC_2130 NSC 7 2.4545 µM 2.0010295509067 0.0270705379989958 no 180 0.0226946026992754 254 21448 SGTC_484 loperamide 105 µM 1.99979840920244 0.0271457797687074 no 181 0.0227610182245315 97 3955 An opioid-receptor agonist. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.99362886525866 0.0275254671278073 no 182 0.0230963142260674 477 16725076 SGTC_976 1348-1067 47.6 µM 1.98869356250575 0.0278323748111969 no 183 0.0233675184914889 247 5310671 YGL099W LSG1 SGTC_1952 st077036 64.1 µM 1.98174797212083 0.0282691194351471 no 184 0.0237537275755056 231 2937007 SGTC_2709 st078560 56 µM 1.9750863949172 0.0286933495260753 no 185 0.0241291722536808 209 17250903 SGTC_3310 9130229 44.1445 µM 1.9745517270099 0.0287276271534773 no 186 0.0241595209074514 226 7761258 SGTC_1671 st016596 74.5 µM 1.96935018522944 0.0290628789245586 no 187 0.0244564459703202 235 2829167 SGTC_2342 7990637 118.86 µM 1.96389048102835 0.0294182602709897 no 188 0.0247713969959958 255 2033102 YER133W GLC7 SGTC_2320 7373003 200 µM 1.95994828648972 0.0296771013674042 no 189 0.0250009174877622 209 5415828 SGTC_3303 9125618 40.5795 µM 1.95818862689641 0.0297932476608222 no 190 0.0251039415814697 303 22695467 SGTC_514 4466-0038 2.65 nM 1.9488827065967 0.030413772052252 no 191 0.0256547168672897 408 5722064 SGTC_177 1327-0068 8.361 µM 1.94690453299375 0.0305470485854136 no 192 0.0257730905496785 274 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1076 itraconazole 331 nM 1.94681547503606 0.0305530600957292 no 193 0.0257784305029265 234 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2888 9058547 12.99 µM 1.94566549132061 0.0306307733211534 no 194 0.0258474672322506 178 16476514 SGTC_2807 7945238 51.95 µM 1.94293684507009 0.0308158240725942 no 195 0.0260118947249652 266 17148797 SGTC_286 k060-0067 22.9 µM 1.93599994619157 0.0312904395381068 no 196 0.0264338537790342 240 5985051 SGTC_2406 ethylparaben 405.7 µM 1.93471145526314 0.0313792590928036 no 197 0.0265128569351269 234 8434 A possible steroid mimic. SGTC_501 nsc-95397 161 µM 1.93020058674285 0.0316918506926501 no 198 0.0267909944471754 185 262093 SGTC_1413 3910-0535 34.4 µM 1.92808390634394 0.0318394157383046 no 199 0.026922345215037 229 2876951 SGTC_1702 st027038 51 µM 1.92738838154133 0.0318880281876304 no 200 0.0269656232345444 246 5521182 SGTC_1344 1488-0097 29.1 µM 1.9208854476986 0.0323455116921518 no 201 0.0273730753874573 231 747966 SGTC_3173 9105693 49.47 µM 1.92082856817 0.0323495369534905 no 202 0.0273766617954503 261 17096658 SGTC_2544 sphondin 68.51 µM 1.91599884408792 0.0326928384972136 no 203 0.0276826214107432 228 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_934 2950-0684 338 µM 1.90724966604788 0.0333223874895421 no 204 0.0282441323875391 254 1121253 SGTC_3025 9087895 49.47 µM 1.90395308927486 0.0335621682171472 no 205 0.0284581469840174 250 17173641 SGTC_1688 st021091 57.6 µM 1.90143671712341 0.0337461540456587 no 206 0.028622417035935 193 3656366 SGTC_2004 4023728 41.89 µM 1.89703932577861 0.0340696634500431 no 207 0.0289113740116882 278 360084 YDR527W RBA50 SGTC_2869 9037858 32.47 µM 1.89581270328761 0.0341603577157953 no 208 0.0289924077462746 192 27187042 SGTC_1232 0279-0259 161 µM 1.89497133465308 0.0342226816946936 no 209 0.0290480997169348 252 1560000 SGTC_1863 st057641 20.1 µM 1.88332742875301 0.035094835892479 no 210 0.0298280042424331 262 3921635 SGTC_2439 5492030 7.2 µM 1.88269358082418 0.0351428312008634 no 211 0.0298709529387569 226 5722370 SGTC_1872 amphotericin b 148 nM 1.88067433213001 0.0352960889796548 no 212 0.0300081166836117 249 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1539 benzyladenosine 56 µM 1.8778920949879 0.0355081540046329 no 213 0.0301979640084046 218 92208 A nucleotide analog. SGTC_2249 haloperidol 116.36 µM 1.86175811739507 0.036758585359665 no 214 0.0313185962578471 417 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_879 0831-1030 162 µM 1.8570725669334 0.0371284037908783 no 215 0.031650415274488 339 1549252 SGTC_840 0245-0196 390 µM 1.85124893196568 0.0375922805686015 no 216 0.0320668745921271 296 3827528 SGTC_398 bronopol 33.3 µM 1.85062748642914 0.0376420594988448 no 217 0.0321115813044214 273 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_148 3253-0744 288.01 µM 1.8499082133707 0.0376997417672599 no 218 0.0321633899491389 249 6893655 SGTC_133 0724-0033 378.92 µM 1.84990638567427 0.0376998884316497 no 219 0.0321635216844418 241 280309 SGTC_117 lucigenin 22.078 µM 1.84713673526678 0.0379226760947076 no 220 0.0323636627897071 359 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_775 4577-0580 57.3 µM 1.83170066272966 0.0391840913050069 no 221 0.0334980149421231 249 2006902 SGTC_1612 st002233 45.4 µM 1.83110319671625 0.039233593787201 no 222 0.0335425707444553 268 1035021 SGTC_997 3996-0078 137 µM 1.83018996490116 0.0393093570887377 no 223 0.0336107689225106 297 735687 SGTC_332 4112-0506 40.9 µM 1.82931392418746 0.0393821467882767 no 224 0.0336762969544268 253 2790355 SGTC_2634 4'-methoxyflavone 100 µM 1.82252173159569 0.0399502344851743 no 225 0.0341879297028425 279 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1168 k815-0004 80.5 µM 1.81979729692446 0.040179965158133 no 226 0.0343949397689344 253 642433 SGTC_1278 0874-0585 172 µM 1.81787274253335 0.0403428939629307 no 227 0.0345417926304315 262 766306 SGTC_1280 0880-0253 10.1 µM 1.81262348647408 0.0407900139339645 no 228 0.0349449564122143 288 6836607 SGTC_2432 5630864 12.22 µM 1.80995980860132 0.0410184331948298 no 229 0.0351510100537221 293 5714970 SGTC_219 mitoxanthrone 164.414 µM 1.80757905243504 0.0412234679281341 no 230 0.0353360204482293 302 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1091 telmisartan 47.6 µM 1.80474739025186 0.0414684164443624 no 231 0.0355571101685928 277 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_196 k015-0023 18.111 µM 1.80463348050486 0.0414782946525787 no 232 0.0355660276551075 293 5211998 SGTC_632 0781-2353 4.65 µM 1.80109734093413 0.0417858968028259 no 233 0.0358437693950777 321 6811515 YHR007C ERG11 SGTC_1656 st012921 11 µM 1.79322908230677 0.0424769717825265 no 234 0.0364681508351742 238 6732821 SGTC_115 0527-0192 112.043 µM 1.79014333587575 0.0427505061496018 no 235 0.036715435823339 404 4233931 SGTC_72 0744-0168 198.391 µM 1.79004729472349 0.0427590424610594 no 236 0.0367231543046064 287 677577 SGTC_473 2-arachidonoylglycerol 10 µM 1.78604683669101 0.0431158360796653 no 237 0.0370458374665231 286 5282280 An endocannabinoid. SGTC_2265 7929201 200 µM 1.77929064754228 0.0437238655705404 no 238 0.0375960617380975 295 1265108 SGTC_430 0958-0115 16.4 µM 1.77802848772104 0.0438382181362722 no 239 0.0376995881075912 306 6833180 SGTC_2625 euphol 100 µM 1.77100898285869 0.0444785990354239 no 240 0.0382796039802324 338 6708538 A triterpene alcohol. SGTC_1362 1611-0397 101 µM 1.75572369383782 0.0458991361225248 no 241 0.0395677995349657 291 27816 SGTC_2326 6164455 177.58 µM 1.75558611144893 0.0459120859555558 no 242 0.0395795526971851 289 2888790 SGTC_1789 tunicamycin 25 nM 1.75442527173592 0.0460214659890309 no 243 0.0396788320882697 305 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2587 piperic acid 92.2 µM 1.75285832659886 0.0461694431689873 no 244 0.0398131641932952 292 5370536 SGTC_900 1112-0045 141 µM 1.75086526613895 0.0463582131549455 no 245 0.0399845605223194 220 56211 YIL048W NEO1 SGTC_3160 9100216 49.47 µM 1.7460273180155 0.0468190108764763 no 246 0.0404031025138862 263 17191039 SGTC_3054 9094397 49.47 µM 1.73774375336883 0.0476165160776971 no 247 0.0411279877450324 341 2598354 SGTC_2150 5556613 200 µM 1.73685587520467 0.0477026388712745 no 248 0.0412063067851142 331 743190 SGTC_2335 9018011 154.17 µM 1.73498145901394 0.0478848639552279 no 249 0.0413720446606209 337 6458208 SGTC_2760 etidronate 98.04 µM 1.73421303151512 0.0479597290282549 no 250 0.0414401457991807 338 3305 A chelator and antioxidant. SGTC_1697 st025554 27.742 µM 1.72927149323137 0.0484434059771791 no 251 0.0418802580562782 279 1269519 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.7219362723347 0.0491685607037115 no 252 0.0425405316770307 269 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_881 0833-0569 170 µM 1.71838319093331 0.0495229191137062 no 253 0.0428633721315817 344 5418700 SGTC_460 trequinsin 123 µM 1.71658150566084 0.0497033833006938 no 254 0.0430278320182614 264 5537 A vasodilator. SGTC_978 1416-0512 87.4 µM 1.71639557156368 0.0497220370522083 no 255 0.0430448332757732 352 6814003 SGTC_1723 st034307 2.5525 µM 1.71403121851479 0.0499597270827992 no 256 0.0432614962723275 323 867466 SGTC_2692 st077426 47.7 µM 1.71258358653676 0.0501057051938464 no 257 0.0433945875099029 327 25238571 SGTC_3012 9080433 71.4286 µM 1.70516988312369 0.0508586352319617 no 258 0.0440813725840079 306 17688859 SGTC_992 3909-8734 162 µM 1.70384214496605 0.0509944255596794 no 259 0.0442052909947232 311 4288319 SGTC_2088 5278280 127.392 µM 1.70266814680717 0.0511147328523309 no 260 0.0443150945559283 360 791502 SGTC_320 4092-0846 5.34 µM 1.69702841248407 0.0516958253370777 no 261 0.0448456445119982 315 1359356 SGTC_865 0488-0499 301 µM 1.69612960466029 0.0517889176626162 no 262 0.0449306691105053 334 9634651 SGTC_633 0437-0093 97.7 µM 1.69429951819192 0.0519788772322055 no 263 0.0451041910456669 298 2831118 SGTC_2638 epoxomicin 18 µM 1.69297319272177 0.0521168930224527 no 264 0.045230284980622 340 9915668 A protesome inhibitor. SGTC_3071 9117417 49.47 µM 1.69168196181321 0.0522515364015768 no 265 0.0453533147701061 249 45595590 YGL055W OLE1 SGTC_1304 1165-0502 251 µM 1.68459978845741 0.0529949509147438 no 266 0.046032906102867 392 767425 SGTC_3216 9129716 49.47 µM 1.68349091447564 0.0531121050263963 no 267 0.0461400483684832 310 8056934 SGTC_3131 9127911 49.47 µM 1.68321002529618 0.0531418139403853 no 268 0.0461672203753216 330 45595681 SGTC_1352 1496-0991 99 µM 1.67863345325791 0.0536277245414313 no 269 0.0466117513099485 327 3000039 SGTC_3127 9126946 49.47 µM 1.67730681262718 0.0537692346446837 no 270 0.0467412505354913 306 27243249 SGTC_970 1315-0089 19.5 µM 1.6748320340461 0.0540340045443653 no 271 0.0469835958870398 318 6811083 YLR033W RSC58 SGTC_999 SEC7.066 22.7 µM 1.66634449293579 0.0549499099379867 no 272 0.047822409799176 380 740511 YDR170C SEC7 SGTC_1737 st035557 69.7 µM 1.66416271053474 0.0551873211520215 no 273 0.0480399588783177 282 5716916 SGTC_1761 st044296 37 µM 1.66394047137744 0.0552115495631363 no 274 0.0480621630838401 346 1826700 SGTC_3282 9108498 15.4605 µM 1.6528460008014 0.056431778142662 no 275 0.0491811046612714 366 16459645 SGTC_2772 vinpocetine 57.06 µM 1.64765573451071 0.0570098814395776 no 276 0.0497116681994816 357 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.64375474928495 0.0574474430852519 no 277 0.0501134359154355 359 5282309 SGTC_1806 st050005 60.3 µM 1.64092177689462 0.0577668617707765 no 278 0.0504068269485364 339 5194765 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.63915750707107 0.0579664883750788 no 279 0.0505902304879242 332 641818 YHR062C RPP1 SGTC_899 1083-0020 478 µM 1.63573928552248 0.0583548016679721 no 280 0.0509470818490889 383 767123 SGTC_2787 5284540 71.43 µM 1.63244390017054 0.0587310920848307 no 281 0.051293003721147 354 736958 SGTC_1824 st053723 68.6 µM 1.63055754239515 0.0589473453197128 no 282 0.0514918570589882 365 675225 SGTC_3240 9133527 49.47 µM 1.62281451529072 0.0598415623986465 no 283 0.0523145309266822 334 17617455 SGTC_90 0870-0863 4.608 µM 1.61764833944655 0.0604440733987431 no 284 0.0528692025931619 406 1738164 SGTC_1513 0337-0559 19 µM 1.61752442730786 0.0604585828685328 no 285 0.0528825636112516 322 775073 SGTC_46 0329-0187a 2.197 µM 1.61743112592158 0.0604695097762142 no 286 0.0528926257451013 476 46494817 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.61570862790343 0.0606715162981168 no 287 0.0530786623463184 374 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1966 st070145 16.1 µM 1.61336116090926 0.0609476656462161 no 288 0.0533330330138099 352 3748532 SGTC_3075 9116269 49.47 µM 1.59748922401646 0.0628406541921515 no 289 0.055078348919286 357 17015205 YNL244C SUI1 SGTC_1427 4048-4900 550 nM 1.59527041093561 0.0631088947484556 no 290 0.0553258896673812 361 24132586 SGTC_1802 st050112 57.9 µM 1.59377744749195 0.0632898859370728 no 291 0.0554929452591255 357 4662563 SGTC_2301 7769476 200 µM 1.59096348591407 0.0636321194262209 no 292 0.0558088967542943 330 977820 SGTC_1201 1889-3372 45.9 µM 1.59051727070189 0.0636865200575991 no 293 0.0558591279055934 316 5392199 SGTC_1019 4262-0212 3.4 µM 1.58841960348504 0.0639427435876905 no 294 0.0560957437573757 446 4677213 SGTC_1932 st074806 40.9 µM 1.58825097519902 0.0639633757695401 no 295 0.0561147992192768 405 17251235 SGTC_573 3702-0553 84.7 µM 1.57919730214439 0.0650787389805197 no 296 0.0571454042949042 370 1222756 SGTC_1053 3366-3204 134 µM 1.57837592647839 0.065180670201389 no 297 0.0572396361697071 412 3632071 YPR165W RHO1 SGTC_2931 9014674 55.67 µM 1.57486195619416 0.0656181467197588 no 298 0.0576441558547445 396 2996810 SGTC_1907 st060210 83.7 µM 1.57241491234884 0.0659241370490632 no 299 0.0579271790497708 426 688793 SGTC_2477 5967686 25.23 µM 1.57077659814265 0.0661296170535088 no 300 0.0581172748375482 387 776118 SGTC_2126 5251174 33.877 µM 1.5703945276196 0.0661776082219193 no 301 0.0581616773998576 467 790722 SGTC_2533 agelasine 13.65 µM 1.56955614860076 0.0662830099935714 no 302 0.0582592035468732 418 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.56811508360095 0.066464485724795 no 303 0.0584271384966106 385 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2651 TUB2.036 5 µM 1.55952784020617 0.0675538779260102 no 304 0.0594357502681167 606 15992207 YFL037W TUB2 SGTC_182 3448-4371 550.524 µM 1.55547937430063 0.0680722353176201 no 305 0.0599159715476949 409 3491403 SGTC_2118 5526350 200 µM 1.54956706869714 0.0688347446257595 no 306 0.0606227310896139 409 743594 SGTC_704 1310-0270 142 µM 1.54340780538116 0.0696360899639256 no 307 0.0613659305250543 434 5718033 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.53907145973614 0.0702045609934794 no 308 0.061893425847055 387 6708514 SGTC_2220 6782180 200 µM 1.53779756659611 0.0703722378427626 no 309 0.0620490593866567 302 833803 SGTC_2466 5983409 37.09 µM 1.53435991297943 0.070826257465809 no 310 0.0624705669066337 402 2879657 SGTC_2770 toltrazuril 17.5 µM 1.53008005652444 0.0713946499506766 no 311 0.0629984570519798 414 68591 Kills coccidiodes. SGTC_1164 k060-0068 93.7 µM 1.52521433733108 0.0720450941740138 no 312 0.0636028228358629 445 5963676 SGTC_156 3474-0145 5.642 µM 1.52241542379952 0.0724213028494566 no 313 0.06395251128041 413 2265471 SGTC_1852 st056254 31.4 µM 1.52028624057942 0.0727084980393258 no 314 0.0642195253249307 386 442583 SGTC_2243 6634756 200 µM 1.51663517063513 0.0732030020110359 no 315 0.0646794102401324 348 885676 SGTC_529 4076-0302 30.3 µM 1.51102493370964 0.0739678664606377 no 316 0.065391049181284 422 5816522 SGTC_1402 3909-7673 35.9 µM 1.5105853257217 0.0740280568755717 no 317 0.0654470675024224 403 5328014 SGTC_25 0118-0223 35.662 µM 1.51036827603687 0.0740577887628633 no 318 0.0654747394084591 415 5333628 SGTC_510 ag-490 170 µM 1.5092590765133 0.0742098715162127 no 319 0.0656162941839427 404 5328779 SGTC_1249 0481-0015 10.2 µM 1.50903923378476 0.0742400425368006 no 320 0.0656443784166039 365 4227577 SGTC_2263 7948595 193.29 µM 1.50841518638482 0.0743257372858798 no 321 0.0657241493278433 337 2971371 SGTC_651 3253-0966 34.4 µM 1.50643857106327 0.0745976664195542 no 322 0.0659773126959174 449 781462 SGTC_541 4513-1321 94 µM 1.50165847656266 0.0752584169119659 no 323 0.0665926664317945 424 747515 SGTC_2600 tangeritin 87.95 µM 1.50151414148374 0.0752784374632557 no 324 0.0666113159120905 397 68077 A bioactive flavone. SGTC_2846 9008642 19.48 µM 1.49812574845375 0.0757496048344764 no 325 0.0670502912292687 399 2992898 SGTC_214 4373-3496 70 µM 1.49776244064257 0.0758002570421999 no 326 0.0670974912181986 590 3779166 SGTC_201 4262-0159 12.803 µM 1.49666092504518 0.0759539875173654 no 327 0.0672407542672395 354 1341029 SGTC_1998 st075797 76.8 µM 1.49628225162031 0.076006890996056 no 328 0.0672900590960963 461 24208315 SGTC_3150 9097574 49.47 µM 1.49589254733937 0.0760613648550243 no 329 0.067340829364657 364 17217476 SGTC_2395 5646831 180.19 µM 1.49442828399668 0.0762663089869145 no 330 0.0675318567506853 421 6808628 SGTC_2341 7987486 176.74 µM 1.4936593075132 0.0763741061635726 no 331 0.0676323447643851 459 1258686 SGTC_1189 1431-2119 7.28 µM 1.49147109056115 0.0766814905836072 no 332 0.0679189278766072 459 3107275 SGTC_1103 duloxetine 36.1 µM 1.49025942695983 0.0768521002816268 no 333 0.0680780181030435 487 60835 A selective serotonin reuptake inhibitor. SGTC_2277 7947813 106.88 µM 1.48608802746817 0.0774416663171532 no 334 0.0686279193407337 429 1246798 SGTC_405 ebelactone b 50 µM 1.48315828190508 0.0778577918790628 no 335 0.0690161811201819 446 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1216 1165-0504 9.65 µM 1.48191016956851 0.0780355817341276 no 336 0.0691820993768662 441 6304004 SGTC_725 1497-0963 19 µM 1.48138950551966 0.078109839746005 no 337 0.0692514048148753 417 3549977 SGTC_2250 alverine citrate 130 µM 1.4801559398517 0.0782859869570804 no 338 0.069415817852857 598 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2065 5221596 34.26 µM 1.47814296589936 0.0785740765414255 no 339 0.0696847579321467 424 788581 SGTC_1055 3448-0672 86 µM 1.47662284138356 0.0787921632953259 no 340 0.0698883827123399 420 748378 SGTC_1006 4099-6547 255 µM 1.47616633260678 0.07885774642037 no 341 0.0699496226109323 439 3146833 SGTC_1776 st049249 45.9 µM 1.47536960695558 0.0789723049622995 no 342 0.0700566009462513 452 1822314 SGTC_2998 9066762 71.4286 µM 1.47461709466907 0.0790806219259576 no 343 0.0701577581850597 498 4945196 SGTC_2825 7998094 58.44 µM 1.47448449205406 0.0790997204612315 no 344 0.0701755950654378 424 2987815 SGTC_1285 0929-0069 65.5 µM 1.47331025846758 0.0792689958244408 no 345 0.0703336979113375 435 1206237 SGTC_2177 5811945 192 µM 1.47181473756215 0.0794849842704606 no 346 0.070535456378986 427 5343475 SGTC_2082 5219693 150 µM 1.46941235858602 0.0798328763098737 no 347 0.0708604886289104 450 2834649 SGTC_2960 9079389 5.97 µM 1.46652505039839 0.0802525139661254 no 348 0.0712526509087787 449 16457355 SGTC_1154 4088-0362 150 µM 1.46280201027918 0.0807960738322809 no 349 0.0717607814317327 508 6618304 SGTC_225 nsc-122657 1.016 µM 1.46015005754888 0.0811849481181646 no 350 0.0721244188355447 295 275685 SGTC_3266 9136860 49.47 µM 1.45814276450362 0.0814802292457752 no 351 0.0724005980220909 449 4871271 YPR165W RHO1 SGTC_361 000s-0510 1.45 µM 1.457628643151 0.0815559887591532 no 352 0.0724714650623268 463 660 SGTC_2391 6285546 200 µM 1.45158354250366 0.0824507661536359 no 353 0.0733087187664471 477 846083 SGTC_482 fipronil 114 µM 1.45030770473038 0.0826405527991887 no 354 0.0734863657352012 328 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3039 9090270 49.47 µM 1.45018581318053 0.0826587019116578 no 355 0.0735033550626594 403 17173750 SGTC_2903 5923464 63.88 µM 1.44964391771162 0.0827394240630616 no 356 0.0735789211832801 414 2876576 SGTC_86 0417-1630 471.922 µM 1.44526536872472 0.0833938414338573 no 357 0.0741916806895954 594 3634867 SGTC_1231 0242-0792 125 µM 1.44357220866053 0.083647941388188 no 358 0.0744296735560564 457 3707635 SGTC_1972 st070201 17.4 µM 1.44106732304016 0.084024926793318 no 359 0.0747828320500616 449 2829099 SGTC_677 0929-0063 136 µM 1.43818441248319 0.0844603822790005 no 360 0.0751908683706577 377 1539583 SGTC_1435 4092-0789 56.7 µM 1.435520774031 0.0848642201781073 no 361 0.0755693764432232 447 2248285 SGTC_387 norethindrone acetate 66.7 µM 1.43479470760183 0.0849745507959919 no 362 0.0756728032447037 407 541197 SGTC_575 k072-0246 11.9 µM 1.43129394320685 0.0855080245758567 no 363 0.0761729945359381 467 6796779 SGTC_2224 6650123 117.647 µM 1.42931753388164 0.085810310882576 no 364 0.0764564943279111 410 2908370 SGTC_2442 5158906 48.48 µM 1.42711109324974 0.0861487239807578 no 365 0.076773937728736 462 1893835 SGTC_198 3454-2873 16.191 µM 1.42625361068131 0.0862805095205292 no 366 0.0768975748807246 452 710957 SGTC_37 0566-0070 1.56 µM 1.42582836312476 0.0863459212436788 no 367 0.0769589458255447 517 1626686 SGTC_3026 9090633 49.47 µM 1.42512354767008 0.0864544178525079 no 368 0.0770607454729574 473 25236842 SGTC_1550 gossypolone 36.6 µM 1.42498267662832 0.0864761152214247 no 369 0.0770811043728177 476 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1330 1469-0054 61.8 µM 1.42172282646075 0.0869793446454248 no 370 0.0775533654233342 461 7102664 SGTC_2519 cryptotanshinone 88.04 µM 1.4132411227076 0.0882989276833495 no 371 0.0787924195181612 433 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2907 7721985 69.9 µM 1.41309120722783 0.0883223849768081 no 372 0.078814454115621 467 3267881 SGTC_483 fpl-64176 144 µM 1.41132369013865 0.0885992988342181 no 373 0.0790745961384306 384 3423 SGTC_2834 9001755 58.44 µM 1.41097048261308 0.0886547126940336 no 374 0.0791266588611374 431 2989575 SGTC_1496 4469-0713 57.4 µM 1.40536432453996 0.0895377085109092 no 375 0.0799564847980201 464 746691 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.4028235589907 0.0899400378075302 no 376 0.0803347299521874 532 4174840 SGTC_1884 5633444 25 µM 1.4002267080173 0.0903526349252773 no 377 0.0807227202034516 520 5724239 SGTC_933 2914-0560 114 µM 1.39778713001244 0.0907415228879396 no 378 0.0810885001373069 532 463887 SGTC_2229 7354935 190 µM 1.39762237676237 0.0907678305619763 no 379 0.081113247553307 401 318112 SGTC_903 1134-0042 114 µM 1.39719341056125 0.0908363541122162 no 380 0.0811777088629954 472 701009 SGTC_1521 st012942 49.4 µM 1.39469442747538 0.0912363078027463 no 381 0.0815540030175861 521 24207259 SGTC_3201 9113999 49.47 µM 1.39113298746192 0.0918085584461124 no 382 0.0820925517050807 482 16649224 SGTC_1504 k297-0033 30 µM 1.38901531939514 0.0921500825038692 no 383 0.0824140458586776 399 4388117 SGTC_2914 7968218 45.32 µM 1.38484494277931 0.0928254026288313 no 384 0.0830499425836788 444 2977111 SGTC_2684 capsaicin 100 µM 1.3816518971553 0.0933449293767857 no 385 0.0835393054344916 465 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1247 0448-0043 5.84 µM 1.38060427125899 0.0935158512316861 no 386 0.0837003346719776 544 3089013 YGL099W LSG1 SGTC_2053 5265679 138 µM 1.38011942039288 0.0935950336289946 no 387 0.083774939364976 526 764595 SGTC_250 brefeldin a 552.239 µM 1.37562062127497 0.0943321076697694 no 388 0.0844695594840178 408 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3126 9127922 49.47 µM 1.37455148121082 0.0945079012580594 no 389 0.0846352697058018 517 45595682 SGTC_1436 4092-1007 8.32 µM 1.37336256049141 0.0947036733097028 no 390 0.084819831398914 468 2881121 SGTC_2070 5230947 200 µM 1.37069004640038 0.0951448300357111 no 391 0.0852357994912594 515 2835538 SGTC_1948 st076329 66.6 µM 1.36945445363126 0.0953493024112485 no 392 0.0854286313568269 451 24208413 SGTC_425 3825-7017 13.1 µM 1.3671830618124 0.0957260278776409 no 393 0.0857839665682911 541 3397440 SGTC_2899 9053889 58.44 µM 1.3670364604197 0.0957503802617174 no 394 0.0858069387549289 461 6470052 SGTC_1880 MG-132 525 µM 1.36675373639406 0.0957973572420948 no 395 0.0858512541268171 457 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_251 melphalan 456.522 µM 1.36645445796272 0.0958471033466202 no 396 0.0858981829681115 562 460612 A DNA alkylator. SGTC_2122 5258151 111.688 µM 1.36243515487315 0.0965170345827666 no 397 0.0865302977772799 503 2173356 SGTC_2796 7949634 45.45 µM 1.35376415541997 0.0979740075548971 no 398 0.0879058163954631 488 2971588 SGTC_1614 st002383 48.6 µM 1.35289414072925 0.098121079590661 no 399 0.0880447257644654 522 1947235 SGTC_2034 5197015 53.07 µM 1.35175380882074 0.0983140923770303 no 400 0.0882270426116718 523 780676 SGTC_2887 9044784 58.44 µM 1.35139948583597 0.098374121736576 no 401 0.0882837492134727 526 6465546 SGTC_1101 ebselen 5.29 µM 1.34992953113697 0.0986234479655029 no 402 0.0885192940057339 538 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_81 0411-0046 9.971 µM 1.34345384755542 0.0997273285951657 no 403 0.0895625304114602 474 12925265 SGTC_331 k048-0133 24.5 µM 1.33990286920021 0.100336466657448 no 404 0.0901384625945143 463 6813582 SGTC_1828 st055811 49 µM 1.33609431257952 0.100992803019147 no 405 0.0907592243653039 448 5877589 SGTC_766 1391-0721 126 µM 1.33257460675482 0.101602138737821 no 406 0.0913357214813027 519 1020919 YIL115C NUP159 SGTC_159 3970-0959 50 µM 1.3317872287016 0.101738816249475 no 407 0.0914650579112646 735 6615653 SGTC_2036 5160441 105 µM 1.32474955707024 0.10296640355668 no 408 0.0926271152052643 606 134534 YIL048W NEO1 SGTC_3281 9140613 49.47 µM 1.32472143808235 0.102971329864792 no 409 0.0926317800029814 472 16013766 SGTC_2557 derrustone 83.84 µM 1.32175278282345 0.103492387303366 no 410 0.0931252429982443 573 629853 An antioxidant. SGTC_1251 0490-5699 265 µM 1.3203994334515 0.103730560772999 no 411 0.0933508463320396 596 3883818 SGTC_2398 5228213 48.84 µM 1.31786751187867 0.104177216403045 no 412 0.0937740014891711 629 80771 YMR134W ERG29 SGTC_1704 st028805 70.8 µM 1.31507225414881 0.104671944489802 no 413 0.0942428102010265 519 2876101 SGTC_1913 st060213 96.1 µM 1.31329149947316 0.104988003379369 no 414 0.0945423709071897 582 688959 SGTC_1112 tnp00069 1.16933 µM 1.31151220809674 0.105304491959181 no 415 0.0948423859781917 605 145826 SGTC_2502 avocadyne acetate 18.59 µM 1.30905609497509 0.105742502301304 no 416 0.0952576749998677 602 3952079 SGTC_2233 sulbentine 40.3845 µM 1.3046425161058 0.106532903850821 no 417 0.0960073019342415 592 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_876 0720-0963 56.8 µM 1.30424351697767 0.106604567889166 no 418 0.096075283386801 584 765861 SGTC_863 0466-0191 129 µM 1.30417988805209 0.106615999465715 no 419 0.0960861277514312 596 765160 YPR165W RHO1 SGTC_583 1488-1091 88.9 µM 1.30393524711375 0.1066599599122 no 420 0.0961278306224796 641 4303273 SGTC_2212 7123476 200 µM 1.30166500130902 0.107068533006975 no 421 0.096515464361945 444 1085715 SGTC_2910 7948405 25.97 µM 1.29923081593827 0.107507862784371 no 422 0.0969323644872525 495 2971328 SGTC_2866 9034245 58.44 µM 1.28965921231056 0.1092479733308 no 423 0.0985845035633259 483 6462273 SGTC_1328 1441-0025 69.2 µM 1.28935553746876 0.109303510471193 no 424 0.0986372557045807 500 4562601 SGTC_1172 0370-0043 85 µM 1.28875906378782 0.109412654747695 no 425 0.0987409308317288 535 376585 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.28875622227875 0.109413174881553 no 426 0.0987414249149104 588 688667 SGTC_1934 st074720 32.6 µM 1.2862340587151 0.109875553682207 no 427 0.0991806939852742 611 17250992 SGTC_1459 k035-0031 35.7 µM 1.28329305433578 0.110416485978924 no 428 0.0996947125745974 489 3877128 YMR208W ERG12 SGTC_2676 harmalol 100 µM 1.27801059212062 0.111392866883305 no 429 0.10062284577876 586 5459187 A monoamine oxidase inhibitor SGTC_2261 9010538 184.68 µM 1.27754621362359 0.11147899459811 no 430 0.100704737884329 483 6457250 SGTC_1987 st072290 61.9 µM 1.27566229141343 0.111828892177965 no 431 0.101037461950281 584 54697379 SGTC_3180 9109287 49.47 µM 1.27527326495986 0.111901243117331 no 432 0.101106268558465 508 18891271 SGTC_3027 9089541 49.47 µM 1.26846411820493 0.113173028543542 no 433 0.102316128370453 587 9943819 SGTC_2664 lyso-paf C-16 73.48 µM 1.2676807473729 0.113320002284594 no 434 0.102455991433513 595 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_825 1988-2224 89.6 µM 1.26757221128286 0.113340376241445 no 435 0.10247538043102 605 1180859 SGTC_1836 st055642 81 µM 1.26659534328444 0.113523867552066 no 436 0.102650009195589 574 8571 SGTC_1876 myriocin 605 nM 1.26210727136056 0.114369612599189 no 437 0.103455094570758 559 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1747 st037496 66.6 µM 1.26166702992213 0.114452813913265 no 438 0.10353431270032 606 723305 SGTC_2468 5987765 72.9 µM 1.26104122522306 0.114571159007013 no 439 0.103646997292795 589 26772094 SGTC_3121 9125696 49.47 µM 1.26020475921818 0.114729477946943 no 440 0.103797753227035 532 1235365 SGTC_2254 7938975 95.19 µM 1.26010054196931 0.114749214172521 no 441 0.103816547398013 686 2969277 SGTC_2565 isoliquiritigenin 100 µM 1.25585644475689 0.115554996633357 no 442 0.104584011238068 469 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_548 1436-0017 110 µM 1.25307126969498 0.1160859686866 no 443 0.105089885364787 671 9677137 SGTC_594 1487-1584 10.8 µM 1.24470161363062 0.117691993070687 no 444 0.106620726308132 591 5013332 SGTC_1866 st057638 64 µM 1.24340523615849 0.117942150237449 no 445 0.106859270870459 575 688802 SGTC_1129 3453-1384 223 µM 1.24295637021602 0.118028853846809 no 446 0.10694195572854 641 1084452 SGTC_1594 piperine 70.1 µM 1.240012710719 0.11859857287139 no 447 0.1074853464073 611 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2055 5235184 200 µM 1.23783182078752 0.119021915934247 no 448 0.107889213433394 582 2836034 SGTC_2670 beta-carotene 100 µM 1.23760517782829 0.119065971819196 no 449 0.107931246803897 496 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2902 5787006 60.46 µM 1.23724963297438 0.11913510743392 no 450 0.107997210174056 571 591003 SGTC_2619 obliquin 87.91 µM 1.23406745450293 0.119755143343816 no 451 0.108588884859422 688 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1090 efavirenz 20.7 µM 1.23127816898084 0.120300493986568 no 452 0.109109422010646 585 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_813 k007-0158 173 µM 1.22847990031053 0.120849356604021 no 453 0.109633435059808 670 6523916 SGTC_277 nystatin 15.5 µM 1.22672801310037 0.121193873892144 no 454 0.109962417601975 620 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1783 st039459 87.517 µM 1.22601470991256 0.121334346195705 no 455 0.110096569761917 667 729761 SGTC_2741 miltefosine 3.04 µM 1.2253664625249 0.121462106188931 no 456 0.110218588565867 482 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1445 4239-0156 97.7 µM 1.22344572717653 0.121841209914538 no 457 0.110580695579757 699 4008346 SGTC_3031 9088762 49.47 µM 1.2232972125075 0.1218705574717 no 458 0.110608729811489 617 205253 SGTC_698 k064-0052 127 µM 1.22312176291363 0.121905233959878 no 459 0.110641854952103 545 5088751 SGTC_2856 9022925 19.48 µM 1.22305773864337 0.121917889672577 no 460 0.110653944598686 622 4944862 SGTC_1300 1094-0077 113 µM 1.21564429119665 0.123389554558816 no 461 0.112060227110729 565 5532636 SGTC_2097 5376186 200 µM 1.21467883895349 0.123582121307555 no 462 0.112244303219739 616 742755 SGTC_93 0109-0045 59.227 µM 1.21383520855031 0.123750561992027 no 463 0.112405329230388 720 88733 SGTC_2536 dehydroabietamide 32.04 µM 1.21280631017345 0.123956211065345 no 464 0.112601941148482 657 3983547 SGTC_1165 k072-0275 30.3 µM 1.21132200623076 0.124253304642587 no 465 0.112886008954697 584 6153523 YGL055W OLE1 SGTC_190 3970-0790 3.722 µM 1.20630638607779 0.125260898901734 no 466 0.113849688119099 578 2832352 SGTC_302 1094-0063 18.9 µM 1.20589062534088 0.125344676913055 no 467 0.113929832887993 549 5440289 SGTC_759 3486-0358 89.3 µM 1.20513288367577 0.125497466503023 no 468 0.114076003526898 666 875103 SGTC_1049 3226-0134 66 µM 1.20499302479296 0.125525681585753 no 469 0.114102997322301 653 5702385 SGTC_3122 9126309 49.47 µM 1.20456725255811 0.125611603980105 no 470 0.114185202510942 594 17591206 SGTC_136 0097-0015 404.482 µM 1.20295657297142 0.125937016235401 no 471 0.114496563076834 667 4861337 SGTC_2160 5660466 132.927 µM 1.20139182810322 0.126253710628096 no 472 0.114799622279319 607 2859134 SGTC_1771 st048882 4.1505 µM 1.19987526733337 0.126561182123052 no 473 0.115093893378911 627 4580403 SGTC_982 1491-0518 27.5 µM 1.19412110155433 0.127732538784942 no 474 0.1162153000044 575 3091256 SGTC_2815 7968870 71.43 µM 1.18688630619986 0.129215966862938 no 475 0.117636234735808 660 2977326 YHR190W ERG9 SGTC_3195 9113082 49.47 µM 1.18528247072996 0.129546429212489 no 476 0.117952890931898 608 17018038 SGTC_452 diindolylmethane 8 µM 1.18497539615213 0.129609767128919 no 477 0.118013587479289 579 3071 Inhibits expression of several cancer promoting factors. SGTC_874 0599-0792 117 µM 1.18406279755089 0.129798128429287 no 478 0.118194102658783 713 765305 SGTC_613 3914-0030 117 µM 1.18328565531441 0.129958680766656 no 479 0.118347977958435 373 1145395 SGTC_1441 4106-0040 13 µM 1.18106409148686 0.130418398854713 no 480 0.118788631737927 612 2904180 SGTC_1921 5740136 50 µM 1.18035964756311 0.130564407169127 no 481 0.118928601994426 691 1774243 SGTC_1252 0493-0875 34.8 µM 1.17935179310875 0.130773499095596 no 482 0.119129061201624 616 3960963 SGTC_2835 9006588 71.43 µM 1.17921771076545 0.130801333577816 no 483 0.119155747741599 621 2345538 SGTC_1668 st014914 51.6 µM 1.17446468147191 0.131790672700727 no 484 0.120104475294217 625 2839556 SGTC_2540 epiandrosterone 100 µM 1.17377374543439 0.131934919133552 no 485 0.120242831389885 770 441302 A steroid. SGTC_1284 0929-0043 16 µM 1.17156514693077 0.132396737557533 no 486 0.120685843966869 656 1239883 SGTC_1424 4048-1941 275 µM 1.16871625171213 0.132994085776335 no 487 0.12125898597522 708 X1424 SGTC_884 0851-0618 334 µM 1.16821653153001 0.133099056641417 no 488 0.121359716907227 673 9642473 SGTC_2823 7987624 58.44 µM 1.16702614027131 0.133349339048246 no 489 0.12159990660466 667 2239440 SGTC_1126 isoteolin 1.0172 µM 1.16546016770262 0.133679081108154 no 490 0.121916387322326 642 133323 SGTC_1121 fusaric acid 630.51 nM 1.16393572587599 0.134000616246195 no 491 0.122225030070853 654 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2078 5212016 200 µM 1.16360027075269 0.134071441687614 no 492 0.122293020821657 600 1899708 SGTC_609 0986-0026 86.3 µM 1.1634247643087 0.134108507028454 no 493 0.122328603413965 671 2848610 SGTC_2745 rifampicin 24.3 µM 1.16204959505677 0.134399173754346 no 494 0.122607660038027 501 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2107 5363541 170.161 µM 1.15840189702409 0.135172274622584 no 495 0.123350032687006 671 244052 SGTC_2767 sibutramine 71.45 µM 1.15768780539442 0.135323976891742 no 496 0.123495731100211 661 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3061 glucosamine 200 µM 1.15595740433852 0.135692068739838 no 497 0.123849290224119 621 91431 and experimental redox chemotherapeutic SGTC_472 calcifediol 10 µM 1.15566460704266 0.135754420517117 no 498 0.123909185190877 588 5283731 A vitamin D metabolite. SGTC_578 3460-0051 92 µM 1.14822883352244 0.137344462573047 no 499 0.125437054580487 743 2876744 SGTC_2595 hexamethylquercetagetin 100 µM 1.14693692305521 0.137622012100083 no 500 0.125703845596857 634 386331 SGTC_348 k064-0012 10.7 µM 1.14171015547386 0.13874881837952 no 501 0.126787259060672 613 5066323 SGTC_463 ikarugamyin 104 µM 1.14168187138425 0.138754933015231 no 502 0.126793139467895 611 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1698 5-fluorocytosine 1.055 µM 1.14031943851842 0.139049689844712 no 503 0.127076621146511 669 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1805 st050013 60.3 µM 1.13970566539638 0.139182616333861 no 504 0.127204473040268 637 4037144 SGTC_386 1509-0011 3.07 µM 1.13862689035116 0.13941645905284 no 505 0.127429403893484 760 3107280 SGTC_2982 9019404 25.97 µM 1.1376208587416 0.139634774109307 no 506 0.127639416439851 550 22333232 SGTC_1701 st028638 40.4 µM 1.13569821426834 0.14005264615705 no 507 0.128041444106195 685 3490878 SGTC_2473 5854593 8.94 µM 1.13308784900173 0.140621347706414 no 508 0.128588681780152 651 2872951 SGTC_1329 1447-1697 50.6 µM 1.13046435474702 0.1411944867388 no 509 0.129140305070431 676 2840515 SGTC_1037 k284-1091 78.7 µM 1.12992052157404 0.141313492609651 no 510 0.129254857947985 624 3334711 SGTC_1027 k015-0025 8.67 µM 1.12821859326831 0.141686361244126 no 511 0.129613806709212 683 3598955 SGTC_1670 st016595 4.04 µM 1.12508400706759 0.142374847811997 no 512 0.130276718842182 688 597879 SGTC_339 3091-4833 71.4 µM 1.12422056257949 0.142564893339614 no 513 0.130459734132421 690 3240077 SGTC_50 0929-0078 56.389 µM 1.12321543226289 0.142786340141584 no 514 0.130673004968595 656 1377751 SGTC_2802 7925815 54.55 µM 1.12191687897592 0.143072776941686 no 515 0.130948891638691 693 1262923 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.12051578283777 0.143382267918616 no 516 0.131247015374914 717 6728940 SGTC_3181 9108277 49.47 µM 1.12009928354801 0.143474356391622 no 517 0.131335727958009 660 17097298 SGTC_2924 9010168 62.78 µM 1.1192464688191 0.143663039267247 no 518 0.131517503042647 696 2993929 SGTC_3007 9078383 71.4286 µM 1.11661986352682 0.144245220095463 no 519 0.13207844743857 706 6496995 SGTC_801 0866-0028 10.1 µM 1.11488111859079 0.144631482466949 no 520 0.132450684438987 726 6849771 SGTC_3233 9132340 49.47 µM 1.11460459813751 0.144692975670828 no 521 0.132509949529379 676 17682950 SGTC_1515 3460-0031 42.1 µM 1.11438488121948 0.144741849337831 no 522 0.132557053259161 603 2876596 SGTC_2861 9024595 19.48 µM 1.11325044608527 0.144994369124751 no 523 0.132800441218981 578 16482810 SGTC_2785 7756463 72.73 µM 1.11277780971557 0.145099663164678 no 524 0.132901933988834 660 2201551 SGTC_1195 1502-0147 41.1 µM 1.11231517828941 0.145202778129064 no 525 0.133001330031386 720 817940 SGTC_937 3122-0005 46.7 µM 1.11137728713823 0.145411974031169 no 526 0.133202992298187 747 759535 SGTC_1295 1013-0063 9.78 µM 1.10995236108254 0.1457301904876 no 527 0.133509777707714 709 6826038 SGTC_448 monastrol 171 µM 1.1094153190142 0.145850244837496 no 528 0.133625528413231 691 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_683 panaxydol 45 µM 1.1072668490163 0.14633119440782 no 529 0.134089286369607 732 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1303 1160-0052 261 µM 1.10467763623124 0.146912220731027 no 530 0.134649648587843 702 3562476 SGTC_1807 st050092 58.9 µM 1.10376079346296 0.147118333188346 no 531 0.134848458157794 675 5008496 SGTC_1769 st044406 64.4 µM 1.10337076390046 0.147206073225017 no 532 0.134933093784021 718 670903 SGTC_1990 st072050 59.8 µM 1.10179788058454 0.147560260869253 no 533 0.135274776001411 715 17233948 SGTC_2286 7945697 125 µM 1.10036541845312 0.147883324266798 no 534 0.135586469739938 677 1245733 SGTC_2708 st078559 56 µM 1.10017280293588 0.147926800962764 no 535 0.135628419028452 591 17250902 SGTC_2513 baicalein 25.65 µM 1.09956486655347 0.148064078969414 no 536 0.135760878402242 691 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2610 ononetin 44.17 µM 1.09934111828824 0.148114624982904 no 537 0.135809651780179 711 259632 SGTC_3056 9094900 49.47 µM 1.09659544351775 0.148735828833437 no 538 0.136409140105462 684 25236784 SGTC_1475 4092-1048 11.7 µM 1.09443730681878 0.149225323887524 no 539 0.136881614677895 756 2881759 SGTC_1940 st075990 51.1 µM 1.09233901343337 0.149702275934867 no 540 0.137342059159822 783 1084979 SGTC_1032 k061-1018 98.7 µM 1.0905344102646 0.150113283402508 no 541 0.137738902042271 802 4005393 SGTC_1063 disulfiram 1.84 µM 1.08969214694055 0.150305370359231 no 542 0.137924388280903 696 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1228 0124-0032 52.5 µM 1.08915986504338 0.150426847239412 no 543 0.138041697129524 720 X1228 SGTC_2730 imipramine 71.33 µM 1.08861550989223 0.150551147099522 no 544 0.138161737145823 843 3696 A tricyclic antidepressant. SGTC_623 k072-0108 16.9 µM 1.08824869238017 0.15063494599848 no 545 0.138242667076788 704 5382803 SGTC_1923 st058458 19.1 µM 1.08796987786672 0.150698661521783 no 546 0.138304202764443 772 3534982 SGTC_1137 ixabepilone 100 µM 1.0879655039368 0.15069966120823 no 547 0.138305168260287 752 154225 A novel microtubule stabilizer. SGTC_1520 flindersine 88 µM 1.08784641404161 0.150726881574943 no 548 0.138331457781027 737 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_449 xestospongin c 11.1929 µM 1.08655030130901 0.151023345644703 no 549 0.138617799581336 741 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1896 st058441 89 µM 1.08570652576255 0.15121655356086 no 550 0.138804426311345 653 688759 SGTC_630 4356-0227 183 µM 1.08224356532115 0.152011224582254 no 551 0.139572157552648 693 779312 SGTC_536 3852-0578 10.6 µM 1.08070397690767 0.152365414404352 no 552 0.139914406750512 742 2869208 SGTC_2433 5607874 27.82 µM 1.07662163026678 0.153307228099855 no 553 0.140824668429551 710 2252428 SGTC_3315 9136395 68.55 µM 1.07489376698088 0.153707012359707 no 554 0.141211146451672 791 16876844 SGTC_1827 berberine 7.24 µM 1.07453947417971 0.153789072027698 no 555 0.141290481281924 665 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1288 0973-0013 65.5 µM 1.07365484268361 0.153994092880091 no 556 0.141488703811952 756 4315430 SGTC_1600 coumarin 106 71.1 µM 1.0724974935149 0.154262591311765 no 557 0.141748319577629 752 100336 A hepatotoxic, DNA x-linker. SGTC_147 4466-0538 29.23 µM 1.07124883871212 0.154552619121066 no 558 0.142028778572211 748 6742687 YHR072W ERG7 SGTC_2463 5473429 200 µM 1.07079380611876 0.154658400088128 no 559 0.142131076271378 700 5399405 SGTC_584 0986-0246 15.4 µM 1.06828476737459 0.155242532816933 no 560 0.14269603876723 802 53315 YDR232W HEM1 SGTC_2958 9077254 16.72 µM 1.06724422995749 0.15548520839189 no 561 0.142930782299629 693 16457351 SGTC_969 1313-0238 134 µM 1.06469826397844 0.156080036910955 no 562 0.143506247967636 778 5212874 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.0633418968541 0.156397544143109 no 563 0.143813465872512 564 6708630 An antioxidant. SGTC_1318 1280-3875 124 µM 1.06119165835031 0.156901757029884 no 564 0.14430140476861 762 373245 SGTC_2993 9054257 71.4286 µM 1.05986379886916 0.157213662505751 no 565 0.144603283521551 734 6470217 YGL055W OLE1 SGTC_1930 st074634 34.3 µM 1.05804487438368 0.157641577212639 no 566 0.14501749224237 741 684253 YOR116C RPO31 SGTC_2474 5321570 43.32 µM 1.05343710340159 0.158729008893583 no 567 0.146070353296913 751 2841384 SGTC_74 000s-0487 160.283 µM 1.05039857712567 0.159448783921552 no 568 0.146767449785736 739 677548 SGTC_59 0330-0160 1.33 µM 1.04980982281614 0.159588496508424 no 569 0.146902779079029 877 4293482 SGTC_2427 5545055 42.75 µM 1.04974936652306 0.15960284744353 no 570 0.146916680117447 813 5372858 SGTC_2743 auranofin 4.32 µM 1.04929142574465 0.159711579491508 no 571 0.14702200553873 729 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_928 2764-0428 58.7 µM 1.04671492252734 0.160324239755724 no 572 0.147615539588755 796 662578 SGTC_1854 st056233 32.9 µM 1.04448632175962 0.16085541035611 no 573 0.148130222170585 730 5393174 SGTC_179 1273-0063 6.77 µM 1.0440850083422 0.160951182388743 no 574 0.14822303064028 704 3108139 SGTC_1900 st060200 72.8 µM 1.04406970796171 0.16095483450703 no 575 0.148226569803775 763 688945 SGTC_1200 1643-0193 18.4 µM 1.04253123912591 0.16132233487474 no 576 0.148582724962425 809 5403974 SGTC_1812 st052057 4.327 µM 1.04141935346952 0.161588276002286 no 577 0.148840482110395 774 3645418 SGTC_3253 9135987 49.47 µM 1.03851630804453 0.162283973663066 no 578 0.149514873448282 703 4182430 SGTC_1826 st055655 41.6 µM 1.03637686154921 0.162797925520148 no 579 0.150013180372416 774 676168 SGTC_3208 9114115 49.47 µM 1.03559791361368 0.162985312073558 no 580 0.150194882874128 665 650895 SGTC_1488 4013-0813 75.9 µM 1.03406455875886 0.163354591017222 no 581 0.15055299171304 725 2910057 SGTC_2194 5927483 104.545 µM 1.03248500345128 0.163735564334816 no 582 0.150922484686073 809 760979 SGTC_1673 st016611 27.3 µM 1.03229624795695 0.163781128864839 no 583 0.150966679116011 797 5226799 SGTC_2293 7624732 200 µM 1.03177263070143 0.163907570245141 no 584 0.151089321774878 699 894453 SGTC_1500 4488-1866 171 µM 1.03152350917127 0.163967749527851 no 585 0.15114769477447 824 2900003 SGTC_390 dec-rvkr-cmk 16.7 µM 1.02839061777267 0.164725772998397 no 586 0.151883060044659 800 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1169 aniline yellow 25.8 µM 1.02821428608232 0.164768504978675 no 587 0.151924519887907 748 6051 A DNA damaging agent. SGTC_38 0929-0051 58.268 µM 1.02817906214676 0.164777041959387 no 588 0.151932802787549 829 1379719 SGTC_2196 6573537 42.6665 µM 1.02672321119527 0.16513013708935 no 589 0.152275408208118 771 2903087 SGTC_7 0192-1582 4.227 µM 1.02578433149649 0.165358108072311 no 590 0.152496626602146 876 252616 SGTC_719 2810-4230 27.3 µM 1.02298341063755 0.166039413734367 no 591 0.153157844771922 748 721079 SGTC_1038 k292-0204 154 µM 1.01827730144212 0.167188221897779 no 592 0.154273096156936 725 4454212 SGTC_2015 5119600 184 µM 1.01744493871243 0.16739194196386 no 593 0.154470906588742 791 2828786 SGTC_1678 st019265 80.2 µM 1.0160149805248 0.167742296291556 no 594 0.15481112644602 808 5367020 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.01523875249108 0.167932677658566 no 595 0.154996016036092 808 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1969 st069479 40.1 µM 1.01259417939998 0.168582341856715 no 596 0.155627020605495 746 3895485 SGTC_1420 4'-methoxyflavone 42 µM 1.01026116480933 0.16915680830548 no 597 0.15618509095571 809 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1454 4239-0054 42.6 µM 1.00747127823421 0.169845420209339 no 598 0.156854176664041 856 1340767 SGTC_522 1273-0010 11.6 µM 1.006778331367 0.170016734638684 no 599 0.157020654903413 774 5705015 SGTC_2512 diallyl trisulfide 49.23 µM 1.00667497939825 0.170042295413071 no 600 0.157045494835492 772 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3098 9119039 49.47 µM 1.00652156225068 0.170080242735431 no 601 0.157082372353359 794 17161528 SGTC_1203 3992-3522 103 µM 1.00562923082686 0.170301066112206 no 602 0.157296978662731 823 5322312 SGTC_207 4185-0010 4.486 µM 1.00120831402216 0.171397808580146 no 603 0.15836305395341 890 3761753 SGTC_1556 plumbagin 1.48 µM 1.00041687084851 0.171594625463044 no 604 0.158554404415207 743 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3179 9107801 49.47 µM 0.997683343456677 0.172275511918895 no 605 0.159216466309169 796 4818259 SGTC_1765 st044815 90.4 µM 0.99758242463773 0.172300682448006 no 606 0.15924094351235 779 645695 SGTC_230 MPP+ 141.667 µM 0.997376744611225 0.172351989113884 no 607 0.159290837494522 764 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2591 skatole 100 µM 0.996352755795429 0.172607567071954 no 608 0.159539389645072 784 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3146 9095609 49.47 µM 0.995611955155434 0.172792614496467 no 609 0.159719361879832 798 17173999 SGTC_1460 k062-0059 9.15 µM 0.994428506036037 0.173088495015443 no 610 0.160007147915686 780 1373085 SGTC_3271 9137798 49.47 µM 0.993801407558618 0.173245410033362 no 611 0.160159780371611 732 6498326 SGTC_412 gemfibrozil 100 µM 0.993469580941976 0.173328477614334 no 612 0.160240583712515 759 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1879 gemcitabine 100 µM 0.993264581665691 0.173379808632778 no 613 0.160290516549217 813 60750 A nucleoside analog which inhibits DNA replication. SGTC_1314 1222-0010 41.1 µM 0.991397248449697 0.173847827057196 no 614 0.160745821650454 813 3526027 SGTC_2163 5671233 125 µM 0.990381945391846 0.174102634073533 no 615 0.160993733390385 862 701023 SGTC_140 0062-0056 502.533 µM 0.988905792268356 0.174473522250089 no 616 0.16135461816134 878 3758964 SGTC_841 0251-0215 91.2 µM 0.986715228609824 0.175024832535652 no 617 0.16189113118001 854 3888614 SGTC_2436 5633522 8.09 µM 0.985903139870396 0.175229495545848 no 618 0.162090322980437 834 5724242 SGTC_3311 9131146 2.8755 µM 0.984963791879094 0.175466419724958 no 619 0.162320928355413 811 4900406 YPR165W RHO1 SGTC_255 tunicamycin 200.472 nM 0.984896649834933 0.175483362194079 no 620 0.162337419575678 819 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2791 5663188 71.43 µM 0.984197977054885 0.1756597252088 no 621 0.162509090131459 789 54690634 SGTC_1093 fluphenazine 7.97 µM 0.981341458476765 0.176381951792496 no 622 0.163212192275105 834 6602611 An atypical antipsychotic. SGTC_121 0557-0495 61.343 µM 0.979941346722191 0.176736633511653 no 623 0.163557535929355 1030 3104427 SGTC_1051 3253-3903 78 µM 0.978467710689878 0.177110427363546 no 624 0.163921526814186 846 5509239 SGTC_2956 9076196 2.52 µM 0.976783858207641 0.177538154357976 no 625 0.164338084505137 831 16423868 SGTC_2213 7173844 200 µM 0.976333545051791 0.177652651911846 no 626 0.164449600859959 840 892728 SGTC_1965 Pectolinarigenin 58.4 µM 0.975195447146556 0.177942234671113 no 627 0.164731660046987 828 5320438 An anti-inflammatory. SGTC_1651 st011928 86.1 µM 0.974511906505428 0.178116300829851 no 628 0.164901215110904 813 720198 SGTC_546 peri-Naphthalide 147 µM 0.973832104715697 0.178289521298815 no 629 0.165069954793472 820 223824 A penicillin ester. SGTC_236 1509-0011 5.31 µM 0.972558652391055 0.178614295593118 no 630 0.165386350510124 1026 3107280 SGTC_392 N-ethylmaleimide 8.33 µM 0.972296580187866 0.178681179246855 no 631 0.16545151233456 798 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1025 k007-0731 70 µM 0.972082995051906 0.178735700139534 no 632 0.165504630580907 806 6256118 SGTC_2752 diclazuril 33.15 µM 0.97190575665154 0.178780950919548 no 633 0.165548717832205 987 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1153 4055-0057 267 µM 0.96781061947774 0.179828489156207 no 634 0.166569479607879 843 882706 SGTC_3325 9138760 55.175 µM 0.962736751798162 0.181131723008423 no 635 0.167839824118901 809 43844959 SGTC_497 capsazepine 133 µM 0.96192935835874 0.181339648060997 no 636 0.168042545006126 829 2733484 A calcium channel blocker. SGTC_826 1683-5028 118 µM 0.961907975195047 0.181345156818912 no 637 0.168047916046216 830 722377 SGTC_979 1426-2828 121 µM 0.961221565817388 0.181522046143713 no 638 0.168220387592113 898 747872 SGTC_519 k048-0011 62.8 µM 0.958727225287463 0.18216575246582 no 639 0.168848089687167 835 6836379 SGTC_1029 k015-0030 64.7 µM 0.956803494496318 0.182663176690309 no 640 0.169333224060865 819 2208316 SGTC_2705 st078069 42.8 µM 0.955887306079511 0.182900375842564 no 641 0.169564586444171 782 1530061 SGTC_913 3487-1245 167 µM 0.955849295192496 0.182910220928352 no 642 0.16957418960197 800 4016153 SGTC_1425 4048-4433 7.33 µM 0.955568268200908 0.182983019147274 no 643 0.169645199732402 901 23734946 SGTC_598 3937-0236 20.2 µM 0.955487049451398 0.183004061704467 no 644 0.169665725704979 917 1379313 SGTC_56 0957-0365 83.25 µM 0.953526045322292 0.183512586652901 no 645 0.170161803128252 840 6752360 SGTC_2764 methyldopa 94.69 µM 0.953326833141284 0.183564295322199 no 646 0.170212250011812 886 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3318 9139014 38.6185 µM 0.951635801263097 0.18400359497537 no 647 0.170640859116783 817 16643984 SGTC_2339 9000433 200 µM 0.948369682892308 0.184853924977837 no 648 0.17147064387085 755 2988954 SGTC_1283 0922-0125 16.4 µM 0.948355589185874 0.184857599541516 no 649 0.171474230073797 918 3360884 SGTC_3004 9076122 71.4286 µM 0.944111932459074 0.185966085650107 no 650 0.172556226152547 865 44782551 SGTC_367 0335-0881 7.1 µM 0.943909363487763 0.186019101574113 no 651 0.172607983367535 862 23828853 SGTC_728 3030-5151 22.5 µM 0.939423812746561 0.187195450384481 no 652 0.173756595847178 839 3125388 SGTC_2123 5259487 200 µM 0.939270446403273 0.187235752322374 no 653 0.173795954050023 898 2173474 SGTC_2252 omeprazole 400 µM 0.93918709851539 0.187257656909823 no 654 0.173817345886833 781 4594 A proton pump inhibitor. SGTC_852 0418-0143 439 µM 0.938967892319642 0.187315273866733 no 655 0.17387361473229 938 5369229 SGTC_2020 4017018 200 µM 0.937675851533902 0.187655101228155 no 656 0.174205508766056 839 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.933509904354729 0.188753403363281 no 657 0.175278379541823 853 115019 SGTC_3273 9137859 49.47 µM 0.93317616830927 0.18884155995456 no 658 0.175364508634805 879 2377234 SGTC_2978 9011784 42.97 µM 0.932679368424804 0.188972836949703 no 659 0.175492770199498 980 2994934 SGTC_2881 9058953 51.95 µM 0.932482789027681 0.189024797636152 no 660 0.175543538600762 935 17122249 SGTC_1146 3579-1023 7 µM 0.932459386390519 0.189030984105012 no 661 0.175549583162717 942 X1146 SGTC_1401 3807-4679 7.6 µM 0.930368410975146 0.189584235107254 no 662 0.176090184149581 846 3291456 SGTC_3174 9107204 49.47 µM 0.930329197218172 0.18959462017915 no 663 0.176100332535262 853 3938802 SGTC_3284 9108171 64.8615 µM 0.929682141342269 0.189766032044183 no 664 0.1762678418306 826 8687505 SGTC_737 1950-0117 57.9 µM 0.927965666573532 0.190221205696438 no 665 0.176712689737367 886 5393513 SGTC_27 0485-0001 32.618 µM 0.925433815790468 0.190893823400764 no 666 0.17737014786184 819 2054479 SGTC_1529 apigenin 74 µM 0.924628526160106 0.191108064094921 no 667 0.177579584684466 885 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2647 atorvastatin 60.16 µM 0.924449804358644 0.191155631547 no 668 0.177626087159961 869 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2531 methyl deoxycholate 70.07 µM 0.923906124499377 0.191300378526998 no 669 0.177767597047276 840 16667744 Haematoxylin. SGTC_469 w7 172 µM 0.922716401913471 0.19161735940846 no 670 0.178077508013828 873 45115570 A P450 inhibitor. SGTC_338 4055-0136 114 µM 0.922324229587225 0.191721917362064 no 671 0.17817973962637 881 2900563 SGTC_2523 spermine 47.74 µM 0.922105718018741 0.191780190380684 no 672 0.178236717339616 883 1103 A DNA binding polyamine. SGTC_2786 7743617 45.45 µM 0.921804845793188 0.191860445216947 no 673 0.178315189692493 780 583674 SGTC_2700 st077718 96.8 µM 0.921478390758162 0.191947547279761 no 674 0.178400359078572 820 904970 SGTC_1166 k206-0078 225 µM 0.921018184751038 0.192070376784338 no 675 0.178520466496578 905 5404595 SGTC_799 1310-0557 151 µM 0.92047102962589 0.192216475675717 no 676 0.178663332693143 882 5354492 SGTC_3237 9133362 49.47 µM 0.917575384731386 0.192990788966214 no 677 0.179420604851827 888 43845137 SGTC_2920 7982904 15.77 µM 0.917343224554231 0.193052952401737 no 678 0.179481406885125 829 6456808 SGTC_601 0986-0029 62.9 µM 0.911448158794907 0.194635514920897 no 679 0.181029644371 914 24747981 SGTC_2359 9039622 200 µM 0.910975924044516 0.194762629500816 no 680 0.181154029668681 939 6463596 SGTC_560 2332-1943 155 µM 0.910159865197645 0.194982412508603 no 681 0.181369103417124 887 21177716 SGTC_2681 menadione 3.18 µM 0.910069063439381 0.195006876784462 no 682 0.181393044260954 890 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2452 5863136 48.41 µM 0.909545735146318 0.195147910948477 no 683 0.181531063859216 895 2184096 SGTC_2732 terfenadine 20 µM 0.908795270211818 0.195350265376586 no 684 0.181729101850683 878 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2797 7859098 81.82 µM 0.906437257451874 0.195986906024233 no 685 0.182352230051366 888 972681 SGTC_662 k832-1615 104 µM 0.90513893030251 0.196337978480807 no 686 0.182695895044363 876 5878478 SGTC_1020 4335-0961 93.3 µM 0.903617091928365 0.196749974148512 no 687 0.183099237511491 847 669075 SGTC_1480 1070-0044 41.2 µM 0.902608430324143 0.197023329686076 no 688 0.183366875349539 918 3124987 SGTC_959 1222-0044 107 µM 0.901073518609738 0.197439744088587 no 689 0.183774615881154 923 6083612 SGTC_1423 4048-0112 5.59 µM 0.897746506739244 0.19834417204301 no 690 0.184660354626373 941 X1423 SGTC_165 k038-0023 64.381 µM 0.89770975649374 0.198354176314682 no 691 0.184670153314123 927 46368543 SGTC_2663 amphotericin b 100 µM 0.894904924726912 0.199118614978586 no 692 0.185418956977818 910 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1565 sinapyl alcohol 95.1 µM 0.894424219151623 0.199249806084488 no 693 0.185547479491127 894 5280507 A phenol propionate derived from cinnamic acid. SGTC_3102 9121669 49.47 µM 0.893870452580146 0.199401001040894 no 694 0.185695604264504 905 41905072 SGTC_708 3448-5400 146 µM 0.893393044804156 0.199531403172605 no 695 0.185823363001196 920 3462195 SGTC_2671 danthron 100 µM 0.891176643509876 0.200137476798157 no 696 0.18641720626831 906 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_275 trichlorophene 5.69 µM 0.890116673504105 0.200427715670999 no 697 0.18670162046429 1003 62616 SGTC_1109 tnp00067 928.257 nM 0.889773073665503 0.20052185372679 no 698 0.18679387378205 905 676295 SGTC_203 k066-0004 30.888 µM 0.888948658795794 0.200747831745234 no 699 0.187015336436325 1061 6795412 SGTC_1320 1313-0481 95.3 µM 0.888155485520614 0.200965390432757 no 700 0.187228559906712 974 6813365 YLR208W SEC13 SGTC_581 0958-0271 211 µM 0.887159928991337 0.201238660717978 no 701 0.187496401373089 994 4591145 SGTC_2734 clemastine 41.6 µM 0.887089877747171 0.201257897468218 no 702 0.187515256657287 836 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2550 chrysin dimethyl ether 71.87 µM 0.886282365916324 0.201479727633161 no 703 0.187732694499739 810 88881 An O-methylated flavonoid and antioxidant. SGTC_2412 st077135 33.4 µM 0.886182762995026 0.201507099524715 no 704 0.187759525256828 912 13258915 SGTC_1734 st037168 69.4 µM 0.884462641645058 0.201980157718515 no 705 0.188223260325349 891 708907 SGTC_1502 4534-4282 27.7 µM 0.883309094006974 0.202297772004418 no 706 0.188534645832223 893 3278949 SGTC_3355 9151058 44.0485 µM 0.881507824180209 0.202794325154248 no 707 0.189021510525375 945 17015728 SGTC_869 0564-0080 44.1 µM 0.88144073054374 0.202812834804816 no 708 0.189039660192474 894 6843321 SGTC_1570 verbenone 133 µM 0.881096467530949 0.202907825231769 no 709 0.18913280452299 958 29025 A natural terpanoid with antifungal properties. SGTC_858 0438-0351 2.77 µM 0.880839167321767 0.202978837883783 no 710 0.189202438515816 973 2799119 SGTC_2662 daunorubicin 22.37 µM 0.879494305517059 0.203350249674517 no 711 0.18956665966913 895 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_488 nitrendipine 139 µM 0.879183325116975 0.203436191125502 no 712 0.189650942061776 968 4507 Dihydropyridine L-type calcium channel blocker. SGTC_802 4112-3352 742 µM 0.878569538178156 0.203605878703722 no 713 0.189817359186303 985 704594 SGTC_1564 D-Arginine 115 µM 0.877890266517403 0.203793768552482 no 714 0.190001635939072 913 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_125 0133-0007 11.75 µM 0.876093130266843 0.204291363378433 no 715 0.190489703539259 1051 26541 SGTC_1188 1403-0014 4.57 µM 0.875927205874209 0.2043373413192 no 716 0.190534804194624 974 9614867 SGTC_2946 9065502 71.43 µM 0.875791438100893 0.204374967390186 no 717 0.190571712720124 777 16489101 SGTC_3170 9103054 49.47 µM 0.874156299592689 0.204828446209469 no 718 0.191016570484003 884 16432970 SGTC_2927 9011802 47.9 µM 0.873739759797421 0.204944062242648 no 719 0.191129996512107 894 43912568 SGTC_2712 st079126 47.7 µM 0.87367196998612 0.204962881855988 no 720 0.191148459949243 904 3152970 SGTC_1899 st063254 59.6 µM 0.872562726166811 0.205270972871581 no 721 0.191450732265682 846 3093813 SGTC_3068 9116768 49.47 µM 0.871766276010412 0.20549235545056 no 722 0.191667947896617 896 41904888 SGTC_2710 st078562 53.7235 µM 0.871340187905003 0.205610849779647 no 723 0.19178421673617 967 17250908 SGTC_2622 2-methoxyxanthone 59.94 µM 0.871191405686552 0.205652235397033 no 724 0.191824825871029 982 71034 A hepatoprotective. SGTC_3136 9095672 49.47 µM 0.870257901342437 0.205912014010191 no 725 0.192079739904186 839 17217380 SGTC_1014 4130-3005 69.3 µM 0.870025058682972 0.205976840539302 no 726 0.192143355032767 939 743608 SGTC_3052 9092717 49.47 µM 0.869795116602718 0.206040871386334 no 727 0.192206190340353 912 25237534 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.869515638978993 0.206118712044374 no 728 0.192282578939491 948 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_166 k072-0058 166.424 µM 0.869487320891577 0.206126600226603 no 729 0.1922903200549 1001 5846229 SGTC_3305 9127027 53.8275 µM 0.868126561158969 0.20650585935915 no 730 0.192662525936807 942 41905295 SGTC_2219 9098279 200 µM 0.867297018793242 0.206737264877816 no 731 0.192889644859001 958 902349 SGTC_1552 6-methylflavone 10.6 µM 0.867235426946991 0.20675445239115 no 732 0.192906514499931 927 689013 SGTC_2083 5306046 65.942 µM 0.866857157755965 0.206860028855775 no 733 0.193010139945836 935 539837 SGTC_2838 9002687 71.43 µM 0.866511673574723 0.206956482767416 no 734 0.193104813753945 880 6457060 SGTC_1082 camptothecin 424.86 nM 0.866216102209157 0.207039022903492 no 735 0.193185832340201 885 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1058 3448-5425 97.3 µM 0.86615720627382 0.207055472285423 no 736 0.193201978688062 927 7279705 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.865526342463337 0.207231718334149 no 737 0.193374981955548 1053 688801 SGTC_665 3914-0008 307 µM 0.864584574374025 0.207494987531923 no 738 0.193633421045922 934 1069549 SGTC_1343 1487-0095 224 µM 0.864046877000402 0.207645388260218 no 739 0.193781069852628 956 4560101 YGL055W OLE1 SGTC_154 3389-1638 511.116 µM 0.863731381177125 0.207733666392283 no 740 0.193867735249913 839 5238686 SGTC_1864 st057645 30.4 µM 0.863325694290871 0.207847213246183 no 741 0.193979210472054 974 688666 SGTC_1801 st050089 28.441 µM 0.862200333205819 0.208162380000222 no 742 0.194288643187837 1005 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2181 6316240 54.2555 µM 0.859926391513222 0.208800076330923 no 743 0.194914809736049 910 12779990 SGTC_2819 7996655 46.38 µM 0.859326020041494 0.208968634314097 no 744 0.195080336258624 855 6456960 SGTC_3051 9093778 49.47 µM 0.8532530980294 0.210678145334228 no 745 0.196759481749261 934 17217378 SGTC_1835 st008666 49.2 µM 0.850473571275359 0.211463303579217 no 746 0.197530923963032 867 690455 SGTC_407 eburnamonine 100 µM 0.849650028322467 0.211696265907568 no 747 0.197759844429315 924 3195 SGTC_2921 7974240 10.71 µM 0.849435431428407 0.211756995346488 no 748 0.197819522307273 950 2979074 YDR527W RBA50 SGTC_2967 9089538 49.85 µM 0.849225285305422 0.211816475126616 no 749 0.197877973000612 1012 728216 SGTC_3234 9132280 49.47 µM 0.84912792797198 0.211844034469342 no 750 0.197905055806886 955 17612295 SGTC_1469 k284-2957 126 µM 0.848937795240946 0.211897862176038 no 751 0.197957953275159 983 23884841 SGTC_2879 9041815 71.43 µM 0.848500927683294 0.212021572287299 no 752 0.198079528020879 903 4942971 SGTC_3265 9137266 49.47 µM 0.847263796216514 0.212372126471393 no 753 0.198424050673888 960 17224265 SGTC_2593 nobiletin 86.24 µM 0.846471751682453 0.212596738320644 no 754 0.19864481297591 909 72344 An anti-infammatory. SGTC_2176 5809774 33.9695 µM 0.839692445894246 0.214524915158994 no 755 0.200540425287483 1014 2870539 SGTC_2460 5552655 174.22 µM 0.83875883967076 0.21479124653232 no 756 0.20080232623343 967 5401989 SGTC_408 cantharidin 100 µM 0.837833842116899 0.215055311454162 no 757 0.201062014560953 980 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_343 4130-2827 29.8 µM 0.835643339951162 0.215681399204686 no 758 0.201677789641533 973 1118244 SGTC_927 2425-1185 123 µM 0.835460723018966 0.215733642322669 no 759 0.20172917629918 976 730375 SGTC_2626 ethyl orsellinate 100 µM 0.833892743702373 0.21618251220889 no 760 0.202170713298849 980 75653 A natural product. SGTC_26 0302-0163 425.158 µM 0.832891289033229 0.216469484269374 no 761 0.202453021452756 1016 3100915 SGTC_218 alverine citrate 93.75 µM 0.832861608423689 0.216477992764966 no 762 0.202461391954536 962 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1080 nisoldipine 24.4 µM 0.832301186526165 0.216638684385872 no 763 0.202619480526748 1007 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_439 amiodarone 34.4 µM 0.831829195609177 0.216774073408065 no 764 0.20275268095385 993 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1975 st070967 30.8 µM 0.831173022488524 0.216962375747444 no 765 0.202937946294569 1067 261391 SGTC_767 0929-0023 86 µM 0.829786420729985 0.21736060039274 no 766 0.20332977486064 1057 1204563 SGTC_1660 st012960 28.1 µM 0.829032699275535 0.217577242126076 no 767 0.203542952163287 961 24207266 SGTC_1191 1487-1166 10.6 µM 0.828267406362003 0.217797337283763 no 768 0.203759538588006 1079 3955771 SGTC_1013 4112-3890 241 µM 0.828207799544212 0.217814485353519 no 769 0.203776413747079 932 705171 SGTC_3220 9131269 49.47 µM 0.826795818751095 0.218220920656703 no 770 0.204176400182022 1013 17722206 SGTC_652 0437-0092 114 µM 0.825836414756283 0.218497331978389 no 771 0.204448447100317 995 3091274 SGTC_2985 9022375 71.43 µM 0.825514750850594 0.218590050816978 no 772 0.204539705825897 1030 4939335 SGTC_3297 9117502 71.43 µM 0.824275372543898 0.218947510307443 no 773 0.204891554324848 1009 7453720 SGTC_2464 5717415 7.67 µM 0.82385740544092 0.219068135480178 no 774 0.205010292574313 989 5285744 SGTC_1540 guanosine 70.6 µM 0.823443110951763 0.219187738442217 no 775 0.20512802784531 960 6802 Guanosine is a purine nucleoside SGTC_1944 st076371 56.9 µM 0.822223805552693 0.219539958296651 no 776 0.20547476625301 956 24208455 SGTC_2189 6047310 154.431 µM 0.822023512756683 0.219597847801549 no 777 0.20553175752236 982 711535 SGTC_1242 0402-0103 60.1 µM 0.821923873102289 0.21962664935774 no 778 0.205560112463697 959 432868 SGTC_1392 3455-1037 33.9 µM 0.821599403504957 0.219720454652851 no 779 0.205652464449666 984 981132 SGTC_195 4234-0266 16.654 µM 0.818800516373199 0.220530577156828 no 780 0.206450118144626 1032 2303354 SGTC_2842 9000675 19.48 µM 0.81745473019975 0.220920716098391 no 781 0.206834304860896 973 2989072 SGTC_479 n-linoleoylglycine 10 µM 0.817417845173794 0.220931414504844 no 782 0.2068448405251 987 6433346 An anti-infammatory. SGTC_3296 9122258 64.045 µM 0.81713714290012 0.221012841189828 no 783 0.206925029400772 998 4730474 SGTC_3205 9113483 49.47 µM 0.815306943703287 0.22154416998762 no 784 0.207448317566731 1020 17018033 SGTC_639 0833-0042 114 µM 0.813686874733386 0.222015104039159 no 785 0.207912177585839 1019 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1302 1159-0335 255 µM 0.813277007260214 0.22213433797834 no 786 0.208029628312909 1001 649284 SGTC_2119 5528445 120.635 µM 0.812986023765589 0.222219009735169 no 787 0.20811303567508 1015 791935 SGTC_2851 9015922 71.43 µM 0.810222020968278 0.223024210160232 no 788 0.208906291687991 1003 2996893 SGTC_2870 9038528 12.99 µM 0.80998658715338 0.223092872692999 no 789 0.208973942327478 944 6463316 SGTC_1666 st014829 29 µM 0.808783787199703 0.223443848187552 no 790 0.209319761725586 1050 3858230 SGTC_1207 2099-0101 141 µM 0.80872535285648 0.223460907252085 no 791 0.20933657087381 1074 5837381 SGTC_301 4119-0100 24.5 µM 0.807172769004416 0.223914433024902 no 792 0.209783476038571 1031 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_428 3448-4153 16.5 µM 0.805802145427039 0.224315240651111 no 793 0.210178470408455 964 3834874 SGTC_1667 st014849 34.6 µM 0.805307791930595 0.224459902944465 no 794 0.210321043230429 1050 5348460 SGTC_2012 4023501 200 µM 0.804895733472578 0.22458052374814 no 795 0.210439925333061 972 3477460 SGTC_2292 7671323 168.05 µM 0.804678724118397 0.224644063113559 no 796 0.210502550090347 1010 937504 SGTC_1355 1499-0035 1.68 µM 0.804085105220408 0.224817924151141 no 797 0.210673913046362 1011 1548538 SGTC_1253 0550-0034 176 µM 0.803971793695749 0.224851119868973 no 798 0.210706632554324 981 5969915 SGTC_3130 9127414 49.47 µM 0.801726245832189 0.225509547994404 no 799 0.211355665140634 1055 1494646 SGTC_3008 9078912 71.4286 µM 0.801081058789343 0.225698928081937 no 800 0.211542360429643 1009 16648731 SGTC_2165 5727197 32.143 µM 0.800996465620691 0.225723765166534 no 801 0.211566845986605 1034 1361712 SGTC_1755 st041960 45.185 µM 0.798207440600029 0.226543505765055 no 802 0.212375060141817 1026 2257073 SGTC_2285 7945142 200 µM 0.79555532868323 0.227324561831975 no 803 0.213145269938188 1016 2970608 SGTC_16 erodoxin 22.806 µM 0.795167132250739 0.227439014175225 no 804 0.21325814405665 1091 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2127 5253358 187.912 µM 0.794871637740415 0.227526156870672 no 805 0.21334408701604 976 20612 SGTC_1390 3413-2614 145 µM 0.790904773750257 0.228697822294698 no 806 0.214499781242816 1108 3421432 SGTC_60 0986-0278 202 µM 0.789521541336828 0.229107173404893 no 807 0.214903622303912 937 3110598 SGTC_2148 5546263 113.568 µM 0.789162713244728 0.229213431389383 no 808 0.215008455910028 1038 792097 SGTC_234 nsc-17383 10.7 µM 0.788644278793345 0.229367001609721 no 809 0.215159971829662 1100 408974 SGTC_3106 9121286 49.47 µM 0.788106629541974 0.229526324524398 no 810 0.215317168851112 1036 15943471 SGTC_545 4218-0007 221 µM 0.787650045356231 0.229661673906407 no 811 0.215450716512046 1014 2840508 SGTC_68 0986-0284 82.829 µM 0.784210358962816 0.230682767057226 no 812 0.216458343892959 907 423278 YIL048W NEO1 SGTC_3354 9151612 71.43 µM 0.783976696253529 0.230752223222009 no 813 0.216526892206109 1069 27261949 SGTC_3089 9117425 49.47 µM 0.783650579692668 0.23084918078973 no 814 0.216622584179437 1031 9401657 SGTC_3059 1327-0034 3 µM 0.782709943080238 0.231128968443974 no 815 0.216898731000577 1034 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1408 3909-7976 48.8 µM 0.782308056907292 0.231248565146333 no 816 0.217016776506472 1113 24152374 SGTC_2161 5662504 8.5105 µM 0.782205922007487 0.231278964818521 no 817 0.217046782374229 1010 2859334 SGTC_3011 9081274 71.4286 µM 0.781221646660381 0.231572041082269 no 818 0.217336072162411 1070 6625322 SGTC_2317 5986382 200 µM 0.781125992293416 0.23160053400696 no 819 0.217364197941162 1089 877883 SGTC_2236 dapsone 200 µM 0.778274665485158 0.232450766093856 no 820 0.218203553784287 1120 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_596 1155-0152 116 µM 0.778094011803761 0.232504693307881 no 821 0.218256796333281 1078 280313 SGTC_1943 st076331 65.2 µM 0.776118656102582 0.23309481355165 no 822 0.218839464614341 1153 24208415 SGTC_635 k038-0028 24.7 µM 0.776057543849291 0.233113083555224 no 823 0.21885750508291 1071 4035102 SGTC_798 1287-0182 476 µM 0.774443133994186 0.233596012286152 no 824 0.219334392115339 1139 1649755 SGTC_1096 rimcazole 32.2 µM 0.772612731539283 0.234144222676197 no 825 0.21987580372553 997 18528119 A dopamine reuptake inhibitor. SGTC_1493 4348-0038 111 µM 0.77218002913486 0.234273922226182 no 826 0.220003904029713 1139 800424 SGTC_645 0845-0943 5.41 µM 0.771656290012408 0.234430962587181 no 827 0.220159012757729 1036 1885106 SGTC_2995 9067767 71.4286 µM 0.770878393146495 0.234664318246541 no 828 0.22038950766151 1035 11673567 SGTC_1561 5-methoxyflavone 52.9 µM 0.770686142377817 0.234722009954277 no 829 0.220446493877892 1067 94525 SGTC_2822 7994718 71.43 µM 0.770199264568706 0.234868150096951 no 830 0.220590850050904 1001 1018011 SGTC_2187 6125751 200 µM 0.770103770651175 0.234896819233112 no 831 0.220619169741438 1063 874498 SGTC_2630 antimycin a 100 µM 0.770058652531258 0.234910365245211 no 832 0.220632550702339 1140 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2052 5265182 7.135 µM 0.767333362659042 0.235729391129056 no 833 0.221441668601363 1082 1239884 SGTC_768 0384-0033 77.3 µM 0.764502999317062 0.23658165882684 no 834 0.222283775000155 1054 3965305 YMR134W ERG29 SGTC_2027 5150920 200 µM 0.763513973279527 0.236879869633666 no 835 0.222578466081173 1098 786715 SGTC_2448 5185112 27.17 µM 0.76343387504861 0.236904029868947 no 836 0.222602341967711 1050 5718189 SGTC_3300 9124615 50.48 µM 0.763050001568773 0.237019837415162 no 837 0.222716788226212 1088 24824903 SGTC_3255 9139072 49.47 µM 0.761708262556572 0.237424859637747 no 838 0.223117071422271 1131 17646060 SGTC_2011 4012611 177 µM 0.761595077556898 0.237459043443639 no 839 0.223150856812881 1127 2049887 SGTC_3140 9094243 49.47 µM 0.760003109734368 0.237940131090121 no 840 0.223626363024906 1169 19291112 SGTC_1696 st025591 34.7925 µM 0.758214281254468 0.238481346375716 no 841 0.224161356530943 1126 2787147 SGTC_1505 k297-0037 20.6 µM 0.757449779855352 0.238712853913814 no 842 0.224390221143834 1095 4089396 SGTC_1179 1021-1431 9.29 µM 0.757230146288695 0.238779386432611 no 843 0.224455996162301 1097 2840958 SGTC_1848 st056003 16.4 µM 0.75674801272259 0.238925472357168 no 844 0.224600422039182 1174 146492 SGTC_2137 5261020 140 µM 0.756712055386184 0.238936369347456 no 845 0.224611195377745 1093 763655 SGTC_3100 9120536 49.47 µM 0.754884750727714 0.23949049777133 no 846 0.225159068148584 1005 16421196 SGTC_1349 flufenamic acid 69 µM 0.754701319957659 0.239546161708513 no 847 0.225214107176083 1069 3371 A non-steroidal anti-inflammatory. SGTC_2299 7976368 114.88 µM 0.753234725628358 0.239991468604137 no 848 0.225654437749267 1100 2979718 SGTC_402 epigallocatechin gallate 10 µM 0.75318271128186 0.240007270176742 no 849 0.225670063486144 1085 65064 An antioxidant. SGTC_1234 0326-0494 15.5 µM 0.750201504933808 0.240913885935774 no 850 0.22656667628401 1125 1547813 SGTC_2789 5281112 71.43 µM 0.749137808549476 0.241237817376535 no 851 0.226887074428881 1099 765948 SGTC_2602 kawain 100 µM 0.747947084500335 0.241600713655123 no 852 0.227246037813087 1134 5369129 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.745882849603001 0.242230531021218 no 853 0.227869093145721 1071 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2400 5203494 178.7 µM 0.745232370174238 0.242429182622262 no 854 0.228065628642043 1089 6777674 SGTC_2589 lobaric acid 100 µM 0.744328679068657 0.242705309609094 no 855 0.228338827525655 1130 73157 A novel microtubule depolymerizer. SGTC_372 0155-0182 15.9 µM 0.743696764543576 0.242898495113736 no 856 0.228529973640379 1139 771486 SGTC_2977 9011197 71.43 µM 0.743590471008816 0.242930998773074 no 857 0.228562134912973 1056 2704722 SGTC_2749 bexarotene 57.39 µM 0.742473221899123 0.243272786365649 no 858 0.228900335127917 1104 82146 An retinoic acid receptor inhibitor. SGTC_3322 9139058 2.11 µM 0.741713160490634 0.243505451972091 no 859 0.229130572201883 1116 4908926 YPR165W RHO1 SGTC_1162 k048-0130 20.1 µM 0.741661330832383 0.243521322144213 no 860 0.229146277121585 1089 6797406 SGTC_119 0121-0043 24.815 µM 0.739858809951469 0.244073599054667 no 861 0.229692834950166 1224 1092378 SGTC_3299 9121982 43.1275 µM 0.739846563342799 0.244077353619361 no 862 0.229696550845013 1159 17594604 YPL160W CDC60 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.739535082134467 0.244172857983917 no 863 0.229791072524275 1136 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1145 3546-0597 10.2 µM 0.738308657578137 0.244549092174367 no 864 0.230163453338171 1096 875334 SGTC_692 k241-0027 77.8 µM 0.736963353039583 0.244962154430508 no 865 0.230572317788317 1147 3600480 SGTC_293 4049-0273 38.5 µM 0.736352187540099 0.245149930595883 no 866 0.230758196972171 1072 1380311 SGTC_385 1494-0393 12.4 µM 0.736250480909466 0.245181186731153 no 867 0.230789138033213 1108 3090647 SGTC_675 1309-0189 238 µM 0.736114608107176 0.245222946041277 no 868 0.230830476698514 1119 4246530 SGTC_3081 9117243 49.47 µM 0.7358525813931 0.245303488443168 no 869 0.230910208777404 1130 45595589 SGTC_2831 7999036 19.48 µM 0.735487154313863 0.245415838038571 no 870 0.231021430213811 1131 2988270 SGTC_2543 pimpinellin 60.67 µM 0.734360948631978 0.245762260875451 no 871 0.231364390350129 1071 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1916 st067606 49.2 µM 0.733382236495838 0.246063527518606 no 872 0.231662665162828 1161 19590279 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.733244278466252 0.246106009610023 no 873 0.231704726829901 1162 688788 SGTC_847 0342-0274 5.54 µM 0.732983189464416 0.24618641879089 no 874 0.231784341226988 1166 18097 SGTC_2147 5545932 89.7195 µM 0.730613145764908 0.246916979634846 no 875 0.232507740092754 1131 797404 SGTC_872 0588-0139 234 µM 0.730274970906413 0.24702131580856 no 876 0.232611062089918 1171 2047100 SGTC_2768 sulfasalazine 50.2 µM 0.729891441024497 0.247139673784569 no 877 0.232728272214055 1169 5384001 An antioxidant and salicylic acid derivative. SGTC_2778 tioconazole 65.09 nM 0.729234661517891 0.247342427485016 no 878 0.232929066050283 1120 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_703 3875-0075 71.8 µM 0.728465154643482 0.247580094203574 no 879 0.233164445819227 1197 2850814 SGTC_1417 3966-0327 90.4 µM 0.726496052354856 0.248188818099039 no 880 0.233767363338447 1182 651118 SGTC_1902 st060212 70.5 µM 0.725898734523552 0.248373629263863 no 881 0.233950426179042 1187 688944 SGTC_659 k018-0002 107 µM 0.72557630153592 0.248473421062446 no 882 0.234049276749106 1149 6797879 YHR007C ERG11 SGTC_362 0310-0100 9.03 µM 0.723762853405879 0.249035074227876 no 883 0.234605669126261 1152 790235 SGTC_1731 st035964 63 µM 0.7226143917334 0.249391119761103 no 884 0.234958411932952 1106 6739575 SGTC_3231 9132313 49.47 µM 0.721238059308238 0.249818165838976 no 885 0.235381529581286 1133 4905967 SGTC_1473 k844-0725 134 µM 0.720476097957469 0.250054752757912 no 886 0.235615955546554 1244 54682906 SGTC_92 0063-0024 660.874 µM 0.720061176068281 0.250183634844561 no 887 0.235743665064295 1218 3594437 SGTC_404 fumagillin 50 µM 0.719300146407187 0.250420115673065 no 888 0.235978002863716 1133 12015870 A methionine aminopeptidase binder. SGTC_750 4073-0104 132 µM 0.718896646775746 0.250545546380717 no 889 0.236102301345689 1013 22330957 SGTC_54 0159-0055 9 µM 0.718246247298107 0.250747797696904 no 890 0.2363027334888 1174 3319099 SGTC_3278 9139605 49.47 µM 0.716091129850014 0.251418580630616 no 891 0.236967540247629 1184 7958859 SGTC_1369 1866-0067 208 µM 0.715895703802266 0.251479454092121 no 892 0.23702787572117 1190 3531355 SGTC_1979 st071809 45.3 µM 0.715348403655936 0.251649974620431 no 893 0.237196893069811 1181 4976333 SGTC_3118 9124250 49.47 µM 0.714551570601302 0.251898350449968 no 894 0.237443089546149 1065 1504786 SGTC_2608 thymoquinone 42.66 µM 0.71356352737875 0.252206506798347 no 895 0.237748558698599 1105 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_305 1682-2595 20.8 µM 0.713141850821242 0.25233808210179 no 896 0.237878992261736 1172 226033 SGTC_2951 9072950 58.06 µM 0.712083611966598 0.252668442575422 no 897 0.238206500869778 1213 16488155 SGTC_400 oxethazaine 37.5 µM 0.710959926089053 0.25301948346621 no 898 0.238554534582228 1116 4621 A local anesthetic. SGTC_2048 5246248 200 µM 0.708862157699408 0.253675515028426 no 899 0.239205010267817 1168 677046 SGTC_2747 doxorubicin 7.63 µM 0.704566979086439 0.255021520852005 no 900 0.240539877028663 1077 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_673 1082-0474 110 µM 0.704399239776584 0.255074162027399 no 901 0.240592089651771 1224 3098046 SGTC_1790 st045711 43.5 µM 0.704257135472641 0.255118762684902 no 902 0.240636327631553 1194 585119 SGTC_2435 5706476 10.6 µM 0.703499626720881 0.255356582124393 no 903 0.240872219651527 1202 5725375 SGTC_235 0330-0087 5 mM 0.701202176237653 0.256078573399833 no 904 0.241588425957644 1217 46494818 YHR062C RPP1 SGTC_533 1222-0222 6.71 µM 0.699785958962772 0.256524160315666 no 905 0.242030492385502 1238 3982874 SGTC_200 k038-0079 37.545 µM 0.697740997534854 0.257168282034128 no 906 0.242669592032944 1150 3436683 SGTC_2103 5378138 10 µM 0.694877163614162 0.258071743565583 no 907 0.243566142567988 1237 244142 SGTC_2193 5925765 200 µM 0.694479963235313 0.258197179307406 no 908 0.243690631049808 1203 877370 SGTC_1422 4031-0024 15.5 µM 0.691809345699117 0.259041379318386 no 909 0.244528533401283 1162 782427 SGTC_64 000l-0018 272.079 µM 0.690713379250679 0.259388234237138 no 910 0.244872839870394 1163 6811119 SGTC_689 0833-0039 98 µM 0.690178143240708 0.259557714575768 no 911 0.245041083242681 1205 5374726 SGTC_2893 9048488 25.97 µM 0.69008403238451 0.259587520311072 no 912 0.245070671998438 1171 6467338 SGTC_591 4299-0174 154 µM 0.688403106783551 0.260120181725807 no 913 0.245599483971124 1168 5509088 SGTC_2505 galangin 7.89 µM 0.688350675312037 0.26013680557031 no 914 0.245615988537738 1125 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2968 9090663 33.37 µM 0.688135526554965 0.260205026049551 no 915 0.245683720071962 1168 25236811 SGTC_21 0849-0113 22.993 µM 0.687933593755873 0.260269064331763 no 916 0.24574730017984 1190 1560156 SGTC_914 3820-6779 408 µM 0.68749019901822 0.260409705128854 no 917 0.245886937440544 1192 2893481 SGTC_964 1287-0107 19.4 µM 0.686863040573294 0.260608700929198 no 918 0.246084519663543 1210 51516812 YPR165W RHO1 SGTC_892 0929-0076 29 µM 0.684648991978204 0.261311838417797 no 919 0.24678272187616 1222 5751038 SGTC_636 0kpi-0074 126 µM 0.684294983379193 0.261424354758602 no 920 0.246894457068411 1188 616434 SGTC_1732 st034308 51.822 µM 0.684043659341367 0.261504249445117 no 921 0.246973798521461 1125 830119 SGTC_786 4544-0069 423 µM 0.683547137451392 0.261662128172581 no 922 0.247130587522492 1212 748821 YLR208W SEC13 SGTC_2784 7567673 72.73 µM 0.679866360882284 0.262834025577075 no 923 0.24829454157278 1246 3471247 SGTC_3219 9131112 49.47 µM 0.676495049711122 0.263909744520253 no 924 0.24936319397418 1173 17612988 YMR079W SEC14 SGTC_3050 9093513 49.47 µM 0.674761396797053 0.264463791469445 no 925 0.249913684982907 1236 25236664 SGTC_499 genistein 192 µM 0.6745572408446 0.264529075289471 no 926 0.249978553541186 1237 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_215 1287-0124 461.5 µM 0.674490759476595 0.264550336089884 no 927 0.249999679274407 1230 5560863 SGTC_3204 9114183 49.47 µM 0.674083099986264 0.264680724963681 no 928 0.250129241629873 1245 17027248 SGTC_604 1000-0114 314 µM 0.674049129664712 0.264691591761573 no 929 0.250140039686231 1264 1572745 SGTC_364 0083-0097 67.7 µM 0.673242635501304 0.264949648552283 no 930 0.250396470456073 1263 5207356 SGTC_2489 cantharidin 73.42 µM 0.672276711910126 0.265258886709001 no 931 0.250703776270251 1222 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1856 st057054 55.7 µM 0.671920906874559 0.265372843014363 no 932 0.250817024936477 1302 1266018 SGTC_2377 9073351 62.6 µM 0.670672132866311 0.265772993618277 no 933 0.251214709635539 1197 7337946 YHR072W ERG7 SGTC_2253 7938677 135.83 µM 0.668827019619809 0.266364791345349 no 934 0.251802914370464 1279 2301972 SGTC_1777 st045864 34.765 µM 0.668119701517992 0.266591831729595 no 935 0.252028593370305 1249 4691462 SGTC_2080 5212524 12.4 µM 0.668095273445846 0.266599674587152 no 936 0.252036389369108 1213 260183 SGTC_1871 st057448 67.3 µM 0.667964191337218 0.266641761698054 no 937 0.252078225214404 1324 691747 SGTC_1925 st057770 10.1 µM 0.666936073554373 0.266971980463905 no 938 0.252406483783069 1183 5989122 SGTC_984 1492-0255 2.91 µM 0.665233520862414 0.267519273274855 no 939 0.25295057173404 1199 1585198 SGTC_1291 0993-0025 5.79 µM 0.664980942495503 0.267600513828573 no 940 0.253031341217567 1259 4353356 SGTC_509 pifithrin 175 µM 0.664485326717531 0.267759962272814 no 941 0.253189868606037 1274 4817 A p53 inhibitor. SGTC_2990 9074105 71.4286 µM 0.66434017508593 0.267806669205434 no 942 0.253236306613288 1211 6502001 SGTC_2594 a-mangostin 100 µM 0.663431817639812 0.268099053903092 no 943 0.253527016874069 1264 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2892 9047358 58.44 µM 0.663325377676581 0.268133325617496 no 944 0.253561093339588 1229 6466771 SGTC_3189 9110682 49.47 µM 0.662586034469562 0.268371441392646 no 945 0.253797858449896 1285 17122418 SGTC_3190 9110366 49.47 µM 0.660948547767228 0.268899195109329 no 946 0.254322655321749 1180 17123768 SGTC_1616 st002734 56.1 µM 0.659999937523438 0.26920516561552 no 947 0.254626934717804 1228 4026101 SGTC_2204 7233102 200 µM 0.659571073572221 0.26934355130185 no 948 0.254764561114617 1191 2172480 SGTC_1719 st032227 49.2 µM 0.659533590114686 0.269355648147112 no 949 0.254776591752233 1262 3125804 SGTC_355 1311-2252 105 µM 0.658715887739945 0.26961960884061 no 950 0.255039114350154 1219 5338538 SGTC_2133 5320837 200 µM 0.658389598686021 0.269724973649925 no 951 0.255143908637827 1246 2841355 SGTC_850 0388-0143 75.9 µM 0.657087391244851 0.270145685951693 no 952 0.255562362901621 1228 67273 SGTC_1340 1486-1359 257 µM 0.656968454393487 0.270184127976407 no 953 0.255600600195244 1224 4309068 SGTC_1483 3453-0561 55.9 µM 0.656487369425479 0.270339649157516 no 954 0.255755295837679 1269 4546991 SGTC_565 1418-0001 44.5 µM 0.656245620403595 0.270417816677788 no 955 0.255833050076326 1293 2862145 SGTC_2109 5483026 200 µM 0.655273913762716 0.270732123781786 no 956 0.256145706518047 1281 759335 SGTC_2570 licareol 100 µM 0.654863587418983 0.270864902216896 no 957 0.256277792981222 1223 443158 SGTC_3177 9107506 49.47 µM 0.65461890182086 0.270944096051968 no 958 0.25635657561036 1201 8897194 SGTC_1865 st057639 52.2 µM 0.654093317144463 0.271114243463872 no 959 0.256525843365897 1257 688818 SGTC_429 1112-0049 25.5 µM 0.652473493658063 0.271638963506682 no 960 0.257047883392114 1233 2836170 SGTC_697 0508-1955 564 µM 0.65237500209497 0.271670884823637 no 961 0.257079643265748 1252 6243113 SGTC_2534 helenine 20.12 µM 0.650885046193447 0.272154010264363 no 962 0.25756034759048 1280 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2757 clomiphene 4.22 µM 0.650061419001556 0.272421258552531 no 963 0.257826274561974 1315 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2288 7946289 167.31 µM 0.649815571855068 0.272501055611036 no 964 0.257905679569114 1311 1246052 SGTC_2855 9016525 58.44 µM 0.64870903793304 0.272860357969314 no 965 0.258263230738514 1264 43811474 SGTC_1224 0823-0416 294 µM 0.648457691571958 0.272942005321081 no 966 0.258344483368301 1308 3598164 SGTC_830 4076-0286 57.8 µM 0.647900632208349 0.273123003650689 no 967 0.258524610908742 1317 6866659 SGTC_1150 3909-7983 10.9 µM 0.647419657595058 0.273279328550364 no 968 0.258680188427333 1253 23965914 SGTC_1315 1237-0019 3.69 µM 0.6458250232501 0.273797928570996 no 969 0.259196340232205 1264 825140 SGTC_2129 girgensonine 121.053 µM 0.645157563245879 0.274015141395484 no 970 0.259412541857093 1325 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_199 4063-0024 41.6 µM 0.644366274641863 0.274272762279572 no 971 0.259668974299222 1294 306215 SGTC_1683 st010134 710 nM 0.642556665547151 0.274862368253421 no 972 0.260255904665448 1277 3818134 SGTC_943 3253-1379 105 µM 0.642168761352707 0.274988836272075 no 973 0.26038180680348 1288 668464 SGTC_3065 9113888 49.47 µM 0.640661566952931 0.275480497289697 no 974 0.260871294777043 1339 16648368 SGTC_1418 3966-3099 2.4 µM 0.63996382912141 0.275708252279305 no 975 0.261098057616641 1290 740335 SGTC_816 0325-0417 81.3 µM 0.639561828055503 0.275839515137387 no 976 0.261228752825775 1260 68101 SGTC_1912 st060209 90.8 µM 0.637324631758614 0.276570573081891 no 977 0.261956704869521 1256 688787 SGTC_2726 cimetidine 79.27 µM 0.63710665087695 0.276641854348199 no 978 0.262027688332847 1276 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2449 5812982 45.77 µM 0.63532911852097 0.27722345563905 no 979 0.262606893148076 1269 776185 SGTC_2235 salicylic acid 500 µM 0.635301341507737 0.277232548908075 no 980 0.262615949420132 1288 338 A COX inhibitor and kinase inhibitor. SGTC_2016 5121758 140 µM 0.633097929113237 0.277954337196711 no 981 0.263334847275817 1274 2795203 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.632849122781623 0.278035898138472 no 982 0.263416087340436 1253 390807 SGTC_3018 9082602 49.47 µM 0.632536373853763 0.278138436596118 no 983 0.263518224042132 1277 17332089 SGTC_3153 9100258 49.47 µM 0.632328448939379 0.278206617459235 no 984 0.26358613878344 1252 25236848 SGTC_931 2812-0076 566 µM 0.631576467824452 0.278453268341022 no 985 0.263831833729146 1317 3450959 SGTC_832 4083-0019 164 µM 0.631312338185721 0.27853992851802 no 986 0.26391816056298 1383 1990758 SGTC_2723 salbutamol 83.58 µM 0.629115503517923 0.279261212266738 no 987 0.264636720677339 1291 9884233 β2-adrenoceptor agonist SGTC_1385 3091-4834 14.1 µM 0.628659570928655 0.279411021655419 no 988 0.264785975738505 1297 4072814 SGTC_2844 9010103 25.97 µM 0.628396018907596 0.279497636834709 no 989 0.264872272204103 1306 2480525 SGTC_487 nimodipine 119 µM 0.62309194258525 0.281243563566934 no 990 0.266612052139309 1214 4497 L-type voltage-gated calcium channels inhibitor SGTC_1985 st071382 65.5 µM 0.621913234092037 0.281632269409847 no 991 0.266999461268461 1323 6123237 SGTC_896 0964-0007 44.5 µM 0.619928700681544 0.282287298953953 no 992 0.267652364579786 1297 6756758 SGTC_3015 9080845 49.47 µM 0.619927874582975 0.282287571774632 no 993 0.267652636530275 1364 5296973 SGTC_1988 st071872 53.4 µM 0.619671694362997 0.282372181916302 no 994 0.267736977416817 1320 16414116 SGTC_1714 st033236 13.627 µM 0.619455181705008 0.282443700330807 no 995 0.267808269198076 1383 2916566 SGTC_3143 9086658 49.47 µM 0.619403838563895 0.282460661263887 no 996 0.267825176512997 1358 25236626 SGTC_223 busulfan 5 mM 0.619020370184528 0.282587353487644 no 997 0.267951469791895 1332 2478 A DNA alkylator. SGTC_868 0527-0199 213 µM 0.618570824374287 0.282735911480652 no 998 0.268099563498846 1317 2849450 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.616302152807312 0.283486194116577 no 999 0.268847559140852 1351 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_625 k213-0058 121 µM 0.613797286690861 0.284315696513684 no 1000 0.269674645232657 1380 3655420 SGTC_1665 st014639 11.4 µM 0.613075830525159 0.284554826328953 no 1001 0.269913100293759 1375 981133 YIL048W NEO1 SGTC_61 0978-8327 98.565 µM 0.612055140008734 0.284893302665167 no 1002 0.270250638212871 1343 6150059 YHR072W ERG7 SGTC_366 0181-0206 4.31 µM 0.611328867167555 0.285134262560921 no 1003 0.2704909419412 1371 274874 SGTC_109 0132-0036 33.701 µM 0.610643834883087 0.285361628815761 no 1004 0.270717698102703 1216 67274 A color developer. SGTC_1937 st074714 47.2 µM 0.610052181578788 0.285558071507146 no 1005 0.270913620753151 1283 17250970 SGTC_2063 5246145 200 µM 0.608080629229591 0.28621313703891 no 1006 0.271566999471343 1372 711240 SGTC_3317 9138495 8.753 µM 0.607323051139952 0.286465038657337 no 1007 0.271818271795837 1314 17020139 SGTC_1767 st044992 70.3 µM 0.606265137019515 0.286816980669705 no 1008 0.272169352575523 1288 9600693 SGTC_579 4491-1009 110 µM 0.606210938855074 0.286835016583172 no 1009 0.27218734491763 1425 1271041 SGTC_1655 st012546 55.1 µM 0.605621821438033 0.287031096094069 no 1010 0.272382954283921 1301 720985 YLR208W SEC13 SGTC_1646 st011709 75.6 µM 0.60350359932072 0.287736640743212 no 1011 0.273086860903486 1318 5757843 SGTC_261 5-fluorouridine 15.376 µM 0.60343454909753 0.287759654011498 no 1012 0.273109822155887 1370 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1031 k035-0009 16 µM 0.596740238360644 0.289994871826534 no 1013 0.275340411552185 1374 5180959 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.596517595602619 0.290069351486368 no 1014 0.27541475138665 1309 688662 SGTC_1554 st069299 38.7 µM 0.596157755859972 0.290189745975709 no 1015 0.275534921809369 1344 24207999 SGTC_14 0354-0009 295 µM 0.59402367973801 0.290904241759889 no 1016 0.276248137556491 1382 1713507 SGTC_1810 st050138 53 µM 0.591905443700058 0.291614246232053 no 1017 0.27695695415983 1352 3444541 SGTC_520 3584-0023 682 µM 0.591868559497731 0.291626616477993 no 1018 0.276969304451671 1325 1340790 SGTC_303 1348-1668 34.2 µM 0.591365551197099 0.291795340115473 no 1019 0.277137758459517 1361 5380509 SGTC_2217 6934799 96.0675 µM 0.590270757833403 0.292162722836443 no 1020 0.277504570404019 1319 675606 SGTC_946 3434-1334 87.4 µM 0.58976337918612 0.29233305819695 no 1021 0.277674648709743 1367 4047976 SGTC_233 rapamycin 362 pM 0.589054637428472 0.292571071749058 no 1022 0.277912311112092 1375 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2942 9052777 62.25 µM 0.587608551174336 0.29305698346772 no 1023 0.278397535009474 1423 6469503 SGTC_2094 5332512 191.667 µM 0.587301382602107 0.293160245971418 no 1024 0.278500656363306 1442 755774 SGTC_907 3448-6986 75.5 µM 0.586976368978475 0.293269525908915 no 1025 0.278609788840845 1436 590582 SGTC_2488 5268135 45.7 µM 0.586266890714062 0.293508140682986 no 1026 0.278848088474265 1410 1270356 YLR208W SEC13 SGTC_702 1488-0190 94 µM 0.585665391324627 0.293710509940762 no 1027 0.279050197810211 1372 949357 SGTC_2724 maprotiline 69.64 µM 0.5845073107094 0.294100317869095 no 1028 0.279439524060808 1362 4011 A tricyclic antidepressant. SGTC_734 2023-0417 80 µM 0.583930068919444 0.294294705705553 no 1029 0.279633681028618 1379 3935732 SGTC_2430 5571206 200 µM 0.582840470879148 0.294661792611299 no 1030 0.28000034887387 1395 1731771 SGTC_1746 st038117 42 µM 0.58186528188206 0.294990513958925 no 1031 0.280328713711369 1374 2898218 SGTC_1274 0865-0114 173 µM 0.581405544413688 0.295145543029767 no 1032 0.280483580789674 1375 870624 SGTC_925 2064-1272 59.6 µM 0.581337565006651 0.295168469696729 no 1033 0.280506483834097 1349 6815817 SGTC_399 oxolinic acid 75 µM 0.579394916287954 0.295823991702325 no 1034 0.281161366782964 1340 4628 A DNA gyrase inhibitor. SGTC_670 4204-0025 119 µM 0.577654919260289 0.296411698574779 no 1035 0.281748560352744 1421 719039 SGTC_496 calpeptin 138 µM 0.576306977630975 0.296867351150215 no 1036 0.282203853685086 1321 73364 A calpain inhibitor. SGTC_3032 9089427 49.47 µM 0.575688907626928 0.29707638809312 no 1037 0.282412737119731 1335 17173707 SGTC_2409 alverine citrate 63.97 µM 0.574696329449428 0.297412227901415 no 1038 0.28274834516357 1495 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2245 6637752 200 µM 0.571277797217167 0.298570216503894 no 1039 0.283905674829698 1405 681890 SGTC_735 3076-0345 636 µM 0.567706133717559 0.299782262322999 no 1040 0.285117262970195 1469 2888990 SGTC_731 3966-0296 387 µM 0.567677859490616 0.299791866079433 no 1041 0.285126864044954 1407 660956 SGTC_523 1934-0222 13.7 µM 0.56749953037388 0.299852441392995 no 1042 0.285187422785739 1372 1361595 SGTC_1463 k081-0032 34.1 µM 0.564446650783205 0.300890309927537 no 1043 0.286225098899089 1285 977755 SGTC_2111 5486399 200 µM 0.56293783242566 0.301403851049366 no 1044 0.286738608645349 1379 689674 SGTC_3183 9108214 49.47 µM 0.562477002298076 0.301560777718704 no 1045 0.286895534139044 1334 4974831 SGTC_1841 st054148 70 µM 0.561603564519003 0.301858310646865 no 1046 0.287193075635831 1336 675442 SGTC_2273 7815444 169.05 µM 0.560848416962379 0.302115654784858 no 1047 0.287450438577637 1475 2824616 SGTC_183 3914-0051 30.55 µM 0.559757659800629 0.302487543946819 no 1048 0.287822373561059 1466 1596232 SGTC_2497 7-hydroxyflavone 100 µM 0.559629923716639 0.302531108460272 no 1049 0.28786594488332 1426 5281894 SGTC_2727 riluzole 51.77 µM 0.558443694839705 0.302935807210153 no 1050 0.288270721314375 1406 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_461 N-acetylfarnesylcysteine 136 µM 0.557750369259175 0.303172457177302 no 1051 0.288507428768159 1398 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1849 st056239 19.2 µM 0.557037331768833 0.303415921522844 no 1052 0.288750961535122 1309 5393181 SGTC_3099 9120367 49.47 µM 0.556196346285034 0.303703185513381 no 1053 0.289038318347679 1398 24824940 SGTC_552 k242-0005 476 µM 0.555780050010949 0.303845428978358 no 1054 0.289180612616315 1399 4088318 SGTC_1458 k015-0034 6.33 µM 0.555721163405753 0.303865552227018 no 1055 0.289200743310961 1343 3598957 SGTC_1105 epirubicin 18.1 µM 0.555390102348515 0.303978696386893 no 1056 0.289313930530109 1339 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1559 coumarin 343 70.1 µM 0.554937607307411 0.304133372467373 no 1057 0.289468668754186 1460 108770 A hepatotoxic, DNA x-linker. SGTC_649 1123-0311 367 µM 0.554332575463084 0.304340244879229 no 1058 0.289675630196279 1383 693629 YIL048W NEO1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.553886741990634 0.30449272428509 no 1059 0.289828179554821 1412 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3228 9131799 49.47 µM 0.553621330708242 0.304583513677761 no 1060 0.289919012343594 1438 17015818 SGTC_2702 st077768 96.8 µM 0.552448819637851 0.304984739244803 no 1061 0.290320445273978 1361 6484119 SGTC_373 0844-0104 25.9 µM 0.552162492852472 0.305082754037214 no 1062 0.290418514582667 1430 5375804 SGTC_572 0960-0087 17.7 µM 0.551278687413388 0.305385384656401 no 1063 0.290721323080773 1356 6796365 SGTC_2426 5582046 32.21 µM 0.55072316229075 0.305575674402166 no 1064 0.2909117320601 1442 2251934 SGTC_1139 k015-0024 46.9 µM 0.550635540977394 0.305605693030856 no 1065 0.290941770018561 1406 2766652 SGTC_2674 ligustilide 100 µM 0.550361496451268 0.305699587763842 no 1066 0.291035726127999 1386 5319022 A signalling regulator. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.549587739826984 0.305964765717145 no 1067 0.291301084907264 1374 689007 SGTC_1233 0325-0408 14.2 µM 0.549283645306529 0.306069011308403 no 1068 0.291405404610101 1465 12874 SGTC_2352 9027995 87.8 µM 0.548773424693023 0.306243953557398 no 1069 0.291580475066481 1428 2997347 SGTC_2957 9076800 11.52 µM 0.548417648575191 0.306365966692776 no 1070 0.291702580463556 1366 16459615 SGTC_991 3996-0057 64.7 µM 0.545662707680028 0.307311497592253 no 1071 0.292648905437813 1427 715343 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.54559991387693 0.307333064196348 no 1072 0.29267049178618 1474 688751 SGTC_1486 3970-0793 4.53 µM 0.544087740239646 0.307852623042285 no 1073 0.293190548250795 1459 2844330 SGTC_2201 6605497 169.863 µM 0.543408863689789 0.308085999682752 no 1074 0.293424162125576 1455 670741 SGTC_2476 5806916 10.51 µM 0.542668818099481 0.30834049276469 no 1075 0.293678923584506 1415 2870194 SGTC_1523 st012844 44.7 µM 0.541960965067302 0.308584001419171 no 1076 0.293922698475538 1459 4274103 SGTC_3144 9087057 49.47 µM 0.540783064499968 0.30898939783523 no 1077 0.294328558587879 1410 17249618 SGTC_19 0279-0214 38.434 µM 0.537955748140047 0.309963420624344 no 1078 0.295303799773625 1459 3566274 YBR002C RER2 SGTC_2735 sertaconazole 140 nM 0.536056435995265 0.310618492241351 no 1079 0.295959773448856 1489 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3034 9090421 49.47 µM 0.535936697391531 0.310659810171245 no 1080 0.296001150498522 1402 17173761 SGTC_2382 9035899 200 µM 0.535616123436898 0.310770441658047 no 1081 0.296111941580133 1436 6462679 SGTC_1743 st037606 46.3785 µM 0.533309696748322 0.311566903598165 no 1082 0.296909608187672 1465 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1531 st059297 52.4 µM 0.532672143908248 0.311787221035332 no 1083 0.297130276109232 1454 7566702 SGTC_1799 st045822 46.1415 µM 0.532411111449618 0.311877444771414 no 1084 0.297220645529094 1474 3674992 SGTC_3040 9091894 49.47 µM 0.531931622295333 0.312043205693265 no 1085 0.297386677365134 1403 25236966 SGTC_864 0469-0573 172 µM 0.529413276636171 0.312914430156445 no 1086 0.298259395062748 1395 689425 SGTC_321 4534-3890 65.3 µM 0.528910552374978 0.313088473554872 no 1087 0.298433750703327 1476 699746 SGTC_3218 9131285 49.47 µM 0.526943171974619 0.313769981842959 no 1088 0.299116526235266 1565 17156417 SGTC_2075 5212009 200 µM 0.523613446093762 0.314924860076206 no 1089 0.300273713702567 1468 780898 SGTC_216 k038-0035 28.382 µM 0.522303833970334 0.315379581553699 no 1090 0.300729400091185 1409 4444231 YPR107C YTH1 SGTC_3217 9129673 49.47 µM 0.521694197437943 0.315591354075849 no 1091 0.300941632703355 1443 17248312 SGTC_1526 st051518 75 µM 0.520790829073731 0.315905273076734 no 1092 0.301256246224089 1455 673993 SGTC_66 0109-0187 42.4 µM 0.52064471531247 0.315956059849021 no 1093 0.301307146761009 1415 759417 SGTC_2773 thioridazine 9.09 µM 0.520470361169273 0.316016667065671 no 1094 0.301367890251683 1452 5452 An antipsychotic. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.519825968283942 0.316240707278998 no 1095 0.301592439041021 1436 3256 An antibiotic and ribosome inhibitor. SGTC_1254 0550-0035 264 µM 0.518232740953928 0.316794924389552 no 1096 0.302147946846011 1538 15121435 SGTC_2402 5553605 200 µM 0.518159538431455 0.316820398378564 no 1097 0.302173481275753 1531 6758546 SGTC_295 k015-0027 31 µM 0.51708053627496 0.31719598462317 no 1098 0.302549970017204 1442 3887424 SGTC_1305 1181-0477 144 µM 0.514021097220602 0.318261957762718 no 1099 0.303618620307958 1542 6252086 SGTC_2128 5255449 168.493 µM 0.511771745098511 0.319046641302574 no 1100 0.304405383615215 1420 736008 SGTC_2032 5185112 25.99 µM 0.511555595339775 0.319122087658151 no 1101 0.304481034800232 1439 5718189 SGTC_1308 1187-1617 41.4 µM 0.51070056891069 0.31942060521198 no 1102 0.304780371152704 1456 2882570 SGTC_3166 9102297 49.47 µM 0.507392025543773 0.320576827004561 no 1103 0.305939889944779 1414 25237072 SGTC_2102 5377816 72.7585 µM 0.507026520529296 0.320704665527626 no 1104 0.306068105239111 1544 1379702 SGTC_2234 tolnaftate 200 µM 0.506914316868571 0.320743913990296 no 1105 0.30610746986461 1480 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_939 1165-0479 45.3 µM 0.505781113086148 0.321140417110484 no 1106 0.306505159356058 1442 1377347 SGTC_3263 9137018 49.47 µM 0.505771619088369 0.321143739881699 no 1107 0.30650849216804 1400 43844957 SGTC_2628 lathosterol 100 µM 0.502950663517802 0.322131669559452 no 1108 0.307499479846175 1509 6710616 SGTC_1770 st043884 66.3 µM 0.502789483562306 0.322188154611823 no 1109 0.307556144112433 1469 670149 SGTC_875 0709-0210 25.7 µM 0.502721540976659 0.322211966126305 no 1110 0.307580031316811 1508 6251364 SGTC_2756 carbadox 75.1 µM 0.502483056084599 0.322295552565929 no 1111 0.307663884117798 1454 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1791 st048313 56.1 µM 0.502216549649759 0.322388970892933 no 1112 0.307757601360388 1553 1204976 SGTC_525 k781-2675 26.7 µM 0.502149842196557 0.322412355568502 no 1113 0.307781061063178 1495 3651118 YDL195W SEC31 SGTC_2334 9017922 200 µM 0.501809784452336 0.32253157565698 no 1114 0.30790066491368 1614 3163164 SGTC_2298 7976326 193.81 µM 0.498873663335369 0.323561701815665 no 1115 0.308934194409486 1418 2235818 SGTC_3232 9132874 49.47 µM 0.497077009774014 0.324192718549507 no 1116 0.309567373134771 1450 3784940 SGTC_104 0074-0074 590.992 µM 0.496785638175647 0.324295101114198 no 1117 0.309670112003773 1424 3943124 SGTC_800 3448-7362 155 µM 0.496158251929174 0.324515598076186 no 1118 0.30989138155174 1547 15991913 SGTC_954 1189-0853 2.85 µM 0.495585227708769 0.324717043093114 no 1119 0.310093538638132 1472 2828194 SGTC_2611 pyromycin 23.93 µM 0.494629043818245 0.325053300945803 no 1120 0.310430998356011 1455 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_231 b-estradiol 524 µM 0.493274978946312 0.32552972403748 no 1121 0.310909152653221 1428 450 A steroid. SGTC_2909 7941780 10.49 µM 0.492343925749928 0.325857477439968 no 1122 0.311238116308999 1537 1243215 SGTC_724 3910-0327 137 µM 0.491088120320625 0.326299764760153 no 1123 0.311682061679464 1459 2885483 SGTC_89 0302-0250 142.109 µM 0.4906915828366 0.326439473736262 no 1124 0.311822300329224 1553 4203518 YLR208W SEC13 SGTC_3291 9121177 71.43 µM 0.488741696039998 0.327126816188252 no 1125 0.312512290084287 1469 17015612 SGTC_2939 9044578 71.43 µM 0.487203172939686 0.327669565663527 no 1126 0.313057178511349 1455 2653634 SGTC_2966 9084041 48.03 µM 0.486106548733591 0.328056647587101 no 1127 0.313445812030057 1367 17741380 SGTC_593 1203-0218 61.7 µM 0.485879175287373 0.328136928072102 no 1128 0.3135264170345 1583 3666956 SGTC_530 4358-1714 28 µM 0.485403350503557 0.328304956863287 no 1129 0.313695128074109 1553 1564641 SGTC_1499 4480-0877 67.3 µM 0.484832605734681 0.328506550730172 no 1130 0.313897545868416 1505 2861909 SGTC_878 0828-0289 13.7 µM 0.484400399051326 0.328659244517553 no 1131 0.314050867639373 1497 745350 YLR208W SEC13 SGTC_2697 mebhydrolin 72.4 µM 0.484176994732197 0.328738181983452 no 1132 0.314130131073509 1627 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_762 1165-0429 115 µM 0.483563274049891 0.328955072777196 no 1133 0.314347922144029 1600 5967793 SGTC_1016 4226-1401 38 µM 0.483354907118492 0.329028723399816 no 1134 0.31442188002374 1493 2901613 SGTC_2072 5231554 129 µM 0.483290540089897 0.329051476297055 no 1135 0.314444728000357 1580 789545 SGTC_540 1187-0821 17.3 µM 0.482580679400513 0.329302444697642 no 1136 0.31469675010179 1470 847520 SGTC_2199 6590217 200 µM 0.482306212612971 0.329399501959184 no 1137 0.314794217299354 1533 703109 SGTC_1941 st076221 61.8 µM 0.480876780714639 0.329905165025086 no 1138 0.315302038077803 1519 2828568 SGTC_1768 st044301 37.178 µM 0.480074014187964 0.330189280972849 no 1139 0.315587382532283 1474 3931349 SGTC_1297 1068-0111 14.1 µM 0.479610472552782 0.330353382719351 no 1140 0.315752199138686 1454 767057 SGTC_1637 st007924 17.4 µM 0.479297638537306 0.330464149809222 no 1141 0.315863450940373 1479 683336 SGTC_839 0122-0028 230 µM 0.478824256679553 0.3306317913168 no 1142 0.31603182939246 1519 759448 SGTC_1107 amlodipine 47 µM 0.478565456922529 0.330723455970295 no 1143 0.31612389870637 1453 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2028 5153890 36.43 µM 0.47636115019808 0.331504613520923 no 1144 0.316908553631357 1504 2830968 YPR165W RHO1 SGTC_262 fenpropimorph 62.5 µM 0.475515666226376 0.331804429153634 no 1145 0.317209734799297 1475 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_952 1185-0122 232 µM 0.473949022399163 0.33236025876202 no 1146 0.31776812997324 1459 678600 SGTC_2657 nystatin 74.44 µM 0.473947699317789 0.332360728334167 no 1147 0.317768601731461 1559 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_682 0kpi-0099 17 µM 0.473406215502624 0.33255292734769 no 1148 0.31796169816204 1502 1714895 YML126C ERG13 SGTC_1467 k284-1082 293 µM 0.471781443532866 0.333129902250563 no 1149 0.318541398711472 1605 3334705 SGTC_3111 9122088 49.47 µM 0.470798258159018 0.333479234518832 no 1150 0.318892404268658 1554 16876704 SGTC_1935 st074532 41.6 µM 0.470295616048997 0.333657882408844 no 1151 0.319071914580624 1661 2829742 SGTC_1587 estradiol valerate 56.1 µM 0.468928653158074 0.334143915870055 no 1152 0.319560317303648 1579 13791 A steroid. SGTC_446 go6976 132 µM 0.468544710984106 0.334280479352946 no 1153 0.319697552522025 1599 3501 A protein kinase C inhibitor. SGTC_986 1493-0483 84 µM 0.468279245962205 0.334374914807142 no 1154 0.319792454036248 1557 40079 SGTC_2355 9061122 103.12 µM 0.467809088269918 0.334542192524479 no 1155 0.319960560407684 1621 5302957 SGTC_2408 sulbentine 18.36 µM 0.467410676992499 0.334683969252855 no 1156 0.32010304256678 1609 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_838 0109-0203 71.4 µM 0.465719494950568 0.33528604738369 no 1157 0.320708148101496 1516 759422 SGTC_1730 st033808 45.1 µM 0.46382939803536 0.335959442211876 no 1158 0.321384989579356 1553 1045166 SGTC_1821 st053465 65.6 µM 0.463087517554345 0.336223900014785 no 1159 0.321650818442776 1493 675086 SGTC_1597 7-benzyloxygramine 47.5 µM 0.460895693233128 0.337005691803101 no 1160 0.322436720901999 1507 260807 SGTC_947 3447-0010 211 µM 0.460248923692105 0.337236519857624 no 1161 0.322668779069492 1514 748350 SGTC_8 0354-0001 70 µM 0.459259059618581 0.337589914879575 no 1162 0.323024071856755 1568 4993152 SGTC_256 clotrimazole 625 nM 0.458655190247931 0.33780557489291 no 1163 0.323240898582202 1546 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1788 fluconazole 20 µM 0.457834645370303 0.338098701626757 no 1164 0.323535621557037 1510 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1749 st037932 54.2 µM 0.453321431089341 0.339712727379465 no 1165 0.325158651472101 1531 594497 SGTC_91 0417-1751 58.384 µM 0.453161177549422 0.339770091892071 no 1166 0.325216342681483 1567 6795624 SGTC_2008 4012253 172 µM 0.452629641804757 0.339960387504838 no 1167 0.32540772532235 1525 603940 SGTC_2646 retinol 96.75 µM 0.451908753182534 0.34021853867836 no 1168 0.325667359176342 1570 445354 A vitamin A analog and teratogen. SGTC_2714 st079313 56.9 µM 0.451360877226559 0.340414783893715 no 1169 0.325864737706371 1548 2939799 SGTC_2983 9022671 12.99 µM 0.45107152430456 0.34051844546798 no 1170 0.325969000081568 1687 6405161 SGTC_3132 9126706 49.47 µM 0.450688211313628 0.340655787078283 no 1171 0.326107139989679 1579 850858 SGTC_1356 1502-0781 85.8 µM 0.448087169934112 0.34158830136371 no 1172 0.327045143571893 1556 567702 SGTC_2558 carylophyllene oxide 100 µM 0.447051030235555 0.341960043615803 no 1173 0.327419107610466 1608 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1674 st016616 23.6 µM 0.446743099272682 0.342070551471832 no 1174 0.327530279613821 1500 625830 SGTC_330 1488-0319 80.1 µM 0.445587273444052 0.342485465834683 no 1175 0.32794770261796 1593 6846614 SGTC_755 1995-0008 37.3 µM 0.445230310308519 0.342613645683308 no 1176 0.328076662257191 1558 689533 SGTC_547 1120-0019 610 nM 0.444855180943604 0.342748368271528 no 1177 0.328212206876372 1578 3676939 SGTC_2451 5856223 45.7 µM 0.444646891022328 0.34282318138947 no 1178 0.328287477556498 1512 2179896 SGTC_2843 9000894 45.46 µM 0.443152599934922 0.343360078170032 no 1179 0.328827680604882 1507 2242070 SGTC_1398 3558-0053 112 µM 0.442941379268698 0.343435995007807 no 1180 0.328904068141248 1531 4532369 SGTC_142 0335-0849 62.6745 µM 0.438969137854956 0.344864869696275 no 1181 0.330341949412046 1604 3889043 YPR107C YTH1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.437792276229736 0.345288630783128 no 1182 0.330768435237888 1589 1609 A potent and irreversible inhibitor of serine proteases. SGTC_102 gallobenzophenone 83.616 µM 0.43736408782906 0.345442859850076 no 1183 0.330923662059913 1661 70837 SGTC_1400 3771-8998 51.5 µM 0.436466337464298 0.345766303603424 no 1184 0.331249208793958 1623 670767 SGTC_742 0kpi-0133 140 µM 0.436010577043422 0.345930549219287 no 1185 0.331414527761204 1679 2728852 SGTC_1378 2093-0007 380 nM 0.435946028012887 0.345953813556005 no 1186 0.331437944427995 1585 3618014 SGTC_1479 0549-0158 134 µM 0.435032758252435 0.346283030513672 no 1187 0.331769324919324 1577 5440202 SGTC_455 paf C-16 10 µM 0.434637447340229 0.346425568873198 no 1188 0.33191280457502 1570 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2311 7694451 200 µM 0.43413268801329 0.346607602968981 no 1189 0.332096044800591 1639 2163142 SGTC_1008 4106-0037 6 µM 0.433417255789356 0.346865673855702 no 1190 0.332355833330978 1568 2905394 SGTC_518 1021-0119 62.6 µM 0.433099848158418 0.346980191977363 no 1191 0.332471116544464 1522 1097762 SGTC_1127 asiatic acid 681.4 nM 0.432113965557578 0.34733597958679 no 1192 0.332829292494916 1541 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_559 1550-0661 158 µM 0.431348512168738 0.347612311006816 no 1193 0.333107490703191 1639 5830875 SGTC_2556 citropten 84.59 µM 0.430071571447722 0.348073471378824 no 1194 0.33357178948711 1534 2775 A potential DNA crosslinker. SGTC_3005 9076496 71.4286 µM 0.429612254404201 0.348239406296361 no 1195 0.333738860696125 1622 21368410 SGTC_1151 3909-8316 15.3 µM 0.42849784423135 0.348642123783237 no 1196 0.334144351363372 1575 800431 SGTC_2112 5488546 200 µM 0.427699937880046 0.34893057025624 no 1197 0.334434797560459 1554 600757 SGTC_2731 amoxapine 43.43 µM 0.426736207897662 0.349279079083894 no 1198 0.334785737448049 1675 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_300 r073-0011 5.04 µM 0.425407829442429 0.34975966223767 no 1199 0.335269699740179 1613 2735780 SGTC_2202 7226349 200 µM 0.422247420904553 0.350904007419764 no 1200 0.336422215880985 1564 844334 SGTC_3350 9150499 3.57 µM 0.421889764072652 0.351033596031251 no 1201 0.336552740840693 1568 4910996 YPR165W RHO1 SGTC_2017 5132927 60.65 µM 0.421584131766631 0.351144348499428 no 1202 0.336664295334153 1541 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_898 1000-0849 28.3 µM 0.419847498197209 0.351773894981515 no 1203 0.337298431848056 1617 6751807 SGTC_67 0335-0847 266 µM 0.418774072007323 0.352163225846089 no 1204 0.337690627771023 1823 4552207 YOR254C SEC63 SGTC_2973 9094665 17.96 µM 0.416945246132596 0.352826896432383 no 1205 0.338359228755108 1713 25237061 YIL048W NEO1 SGTC_1995 st072814 61.1 µM 0.415855965938013 0.353222403132894 no 1206 0.338757701490864 1558 5769371 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.413411701536891 0.354110467636878 no 1207 0.33965250142036 1620 165521 SGTC_723 4182-0001 115 µM 0.413012679965637 0.354255518024217 no 1208 0.339798661839935 1580 744821 YLR208W SEC13 SGTC_1116 jasmonic acid  1.58368 µM 0.412751595979755 0.354350437455392 no 1209 0.339894309169346 1665 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2711 st079103 59.1 µM 0.411771314045979 0.354706908489479 no 1210 0.340253524457692 1715 54693780 SGTC_2221 6807166 181.081 µM 0.410960396885851 0.355001887692741 no 1211 0.340550787203598 1662 674925 SGTC_1065 prochlorperazine maleate 2.48 µM 0.410567161033694 0.355144962465286 no 1212 0.340694973701358 1631 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_153 4077-0274 519.67 µM 0.410502360952294 0.35516854126124 no 1213 0.340718735969043 1733 3121976 SGTC_1258 0671-0043 57.1 µM 0.408886369969094 0.355756730804127 no 1214 0.341311526024956 1563 4298767 SGTC_3327 9140648 26.9345 µM 0.408142455851544 0.356027616768336 no 1215 0.341584546018677 1723 8029710 SGTC_1260 0700-1617 7.75 µM 0.407338979599418 0.356320273108803 no 1216 0.341879518723822 1635 2853078 SGTC_2290 7904846 200 µM 0.406665963647388 0.356565476041918 no 1217 0.342126671081045 1591 2962154 SGTC_70 0141-0289 43.283 µM 0.406067603683109 0.356783529021508 no 1218 0.342346464256525 1697 352408 SGTC_2183 6420625 130.508 µM 0.405160669393241 0.357114121174388 no 1219 0.342679706613503 1580 2897619 SGTC_612 0302-0167 22.4 µM 0.404672761858913 0.357292015734508 no 1220 0.342859033190182 1712 235821 SGTC_298 1391-0729 10 µM 0.404276026250377 0.357436691231172 no 1221 0.343004876347445 1608 3237558 SGTC_619 1652-1634 108 µM 0.404259535574561 0.357442705243287 no 1222 0.34301093895724 1603 5400454 SGTC_175 3793-3120 23.7 µM 0.402913329370735 0.357933774724202 no 1223 0.343505992584852 1609 5322297 SGTC_2980 9014342 25.29 µM 0.402824253355988 0.35796627620252 no 1224 0.343538758864874 1623 2996599 SGTC_459 nigericin 15.3 µM 0.398870284044566 0.359410008895354 no 1225 0.344994392970274 1644 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2414 st077232 92.9 µM 0.395658539060826 0.360584209687882 no 1226 0.346178472845726 1554 729801 SGTC_2059 5238311 157 µM 0.392936270536477 0.361580490758447 no 1227 0.347183275876798 1604 703021 SGTC_821 1114-0266 29.2 µM 0.392132625828379 0.361874784144035 no 1228 0.347480111065234 1610 3123235 SGTC_491 tetrandrine 80.3 µM 0.391951111647341 0.361941265658387 no 1229 0.347547168322152 1720 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2284 7945075 39.21 µM 0.389534889362978 0.362826629089717 no 1230 0.348440253334012 1791 1245402 SGTC_57 miconazole 162.5 nM 0.388826408855128 0.363086373157413 no 1231 0.348702281815842 1584 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_43 0570-0105 72.5 µM 0.385371827061289 0.36435379688518 no 1232 0.349980976253248 1669 1114046 YDL195W SEC31 SGTC_3047 9092122 49.47 µM 0.385048324659092 0.36447256031399 no 1233 0.350100806316719 1603 17173831 SGTC_2354 9060492 162 µM 0.385005874409032 0.364488145514263 no 1234 0.350116531623893 1749 6471895 SGTC_2793 7325131 81.82 µM 0.383216675561711 0.365145236035197 no 1235 0.350779557384884 1697 4176441 SGTC_2323 6148992 148.28 µM 0.381826857940336 0.365655925677698 no 1236 0.35129489783835 1615 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3246 9135460 32.98 µM 0.380491178637015 0.366146946646237 no 1237 0.351790421738743 1707 41446951 SGTC_3191 9110352 49.47 µM 0.37968685846191 0.366442735783954 no 1238 0.352088938185812 1668 17122424 SGTC_550 4123-0385 25.7 µM 0.379610466406549 0.366470833128699 no 1239 0.352117295177395 1622 5731123 SGTC_1374 2889-5571 141 µM 0.377107554045708 0.367391810726243 no 1240 0.353046838811788 1645 2853281 SGTC_2820 7989630 71.43 µM 0.376536214517805 0.367602149381618 no 1241 0.353259148869296 1787 2984098 SGTC_803 4488-1585 147 µM 0.376509836916346 0.367611861255706 no 1242 0.353268951902935 1736 747204 SGTC_1908 st060353 56.5 µM 0.37615926726534 0.367740944270557 no 1243 0.353399247673002 1848 4227716 SGTC_2989 9073649 71.4286 µM 0.375255154475584 0.368073915952045 no 1244 0.353735357375913 1790 21367202 SGTC_505 gw-5074 63.9 µM 0.374958966840704 0.368183019151027 no 1245 0.353845491833968 1736 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1808 st050063 61.5 µM 0.370916583800635 0.369673124203899 no 1246 0.355349831388925 1741 4011993 SGTC_1905 st060207 84.5 µM 0.370507494701947 0.369824032358191 no 1247 0.355502196658945 1665 1948547 SGTC_2818 7996756 12.99 µM 0.369980246244363 0.370018557679164 no 1248 0.35569860445481 1638 2241621 SGTC_916 4466-0038 42 nM 0.368682643981672 0.370497442210558 no 1249 0.356182143455614 1778 5722064 YGL116W CDC20 SGTC_1326 1431-2094 10.8 µM 0.36850221134679 0.370564047402917 no 1250 0.356249398281139 1632 616278 SGTC_610 4215-0184 155 µM 0.367397774844555 0.37097182535531 no 1251 0.356661165569335 1691 5605015 SGTC_3185 9108267 49.47 µM 0.366418016944711 0.37133369104802 no 1252 0.357026588804534 1619 4910486 SGTC_3128 9127691 49.47 µM 0.364205388094176 0.372151325832104 no 1253 0.357852321892089 1685 41316314 SGTC_2744 captopril 92.04 µM 0.364070258477616 0.37220127912863 no 1254 0.35790277264797 1795 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3224 9130643 49.47 µM 0.361374441259431 0.37319828891191 no 1255 0.358909775902483 1746 17644395 SGTC_3213 9129884 49.47 µM 0.36134070297477 0.373210771935166 no 1256 0.358922384829483 1558 17190742 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.360028688571728 0.373696314838512 no 1257 0.359412839876181 1831 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2418 pentamidine 31.67 µM 0.359692296401431 0.373820837288515 no 1258 0.35953862679168 1614 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2345 9052315 157.45 µM 0.357615271214119 0.374589981962012 no 1259 0.360315624182562 1688 6469265 SGTC_1686 st019653 115.5 µM 0.355960707910581 0.37520304190215 no 1260 0.36093499547591 1790 97252 SGTC_3338 9144300 39.5675 µM 0.355658722793011 0.375314969540602 no 1261 0.361048080382611 1744 4901274 SGTC_1611 st001856 99.4 µM 0.355570851002184 0.375347540276793 no 1262 0.361080988170967 1653 647478 SGTC_55 0767-0285 6.563 µM 0.353881688486946 0.375973821153909 no 1263 0.361713775334856 1834 3116166 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.353712575866422 0.376036540072563 no 1264 0.361777148477051 1745 5393153 SGTC_1432 4049-0298 68.4 µM 0.350112063461889 0.377372639207292 no 1265 0.363127298916804 1821 741646 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.349176885108295 0.377719911632548 no 1266 0.363478259201909 1601 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2005 4024620 188 µM 0.349017349511346 0.377779164022029 no 1267 0.363538142290799 1683 236743 SGTC_2043 5101342 149 µM 0.348454385840009 0.377988274766308 no 1268 0.363749482288814 1719 678451 SGTC_3091 9116372 49.47 µM 0.348302490978822 0.378044701670071 no 1269 0.363806511651872 1721 17169793 SGTC_3287 9117173 37.0625 µM 0.347428944148289 0.378369263073501 no 1270 0.36413454586156 1730 2789709 SGTC_1481 3346-2004 36 µM 0.345337983599401 0.379146495912066 no 1271 0.364920147141748 1717 2770522 SGTC_1156 4092-0367 4.88 µM 0.343938172623912 0.379667094283245 no 1272 0.365446391772125 1729 1357585 SGTC_371 0195-0006 7.36 µM 0.343102406244912 0.379978025069492 no 1273 0.365760710481631 1619 3928593 SGTC_893 0958-0369 48.9 µM 0.34110692693712 0.380720718190873 no 1274 0.366511543344217 1848 6819948 SGTC_1135 dihydrocapsaicin 536.708 nM 0.340970630227833 0.380771462242966 no 1275 0.366562845970071 1606 107982 A Capsaicinoid. SGTC_2403 6032726 181.2 µM 0.339232787752771 0.381418650549136 no 1276 0.367217185538996 1697 2881040 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.338943965940479 0.38152624260722 no 1277 0.367325971352089 1695 279621 SGTC_2929 9013348 24.6 µM 0.336933542300103 0.38227541994539 no 1278 0.368083499550301 1721 2995952 SGTC_17 0960-0276 49.807 µM 0.336924786306307 0.382278683802218 no 1279 0.368086799935891 1736 6821114 SGTC_306 1672-3436 11.6 µM 0.336530664614368 0.38242560402814 no 1280 0.368235365802324 1778 6797378 SGTC_1087 pterostilbene 9.05 µM 0.336266038689621 0.382524260471809 no 1281 0.368335128741431 1831 5281727 Similar to reservatol, lowers cholesterol. SGTC_1545 lovastatin 49.4 µM 0.335821917708183 0.382689852451059 no 1282 0.368502580564746 1745 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1035 k081-0041 55.2 µM 0.335280422078705 0.382891779905586 no 1283 0.36870678041194 1845 731709 SGTC_2766 oltipraz 83.91 µM 0.335045343154638 0.382979452370221 no 1284 0.368795441020269 1806 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2278 7948257 134.34 µM 0.332708762246106 0.383851203298806 no 1285 0.369677067356472 1889 1247028 SGTC_2470 5664817 21.68 µM 0.331803355810582 0.384189158157674 no 1286 0.370018875069022 1733 2859561 SGTC_2376 9072922 81.32 µM 0.33056719407925 0.384650713940844 no 1287 0.370485714817136 1758 17087968 SGTC_862 0452-0056 10.2 µM 0.326978781461346 0.385991473103275 no 1288 0.371841966916898 1774 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2000 st075254 36.4 µM 0.324533079914027 0.386906056629121 no 1289 0.37276724106784 1716 17234175 SGTC_1939 st074455 53.6 µM 0.323429841517781 0.38731882464625 no 1290 0.373184866342464 1871 1644229 SGTC_1951 sophoraflavanone G 9.2 µM 0.322311109470838 0.387737519618799 no 1291 0.373608508855576 1693 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3285 9112818 20.8695 µM 0.322109280932366 0.387813069580849 no 1292 0.373684953760006 1752 17017947 YPR165W RHO1 SGTC_424 splitomicin 100 mM 0.321862141657059 0.387905586379683 no 1293 0.37377856740107 1663 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1377 2944-0135 198 µM 0.320729300759656 0.388329747696818 no 1294 0.374207770303791 1778 1894137 SGTC_2667 digitoxin 100 µM 0.319614534448364 0.388747271534487 no 1295 0.374630277495123 1859 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2769 toremifene 3.73 µM 0.314086617311521 0.39081958432289 no 1296 0.376727626721622 1780 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1059 3448-6867 171 µM 0.313619277620039 0.390994924378603 no 1297 0.376905108155625 1925 3934407 SGTC_2388 9080168 200 µM 0.313581280725991 0.391009181316558 no 1298 0.376919539367034 1678 15943073 SGTC_3163 9099914 49.47 µM 0.313046261317022 0.391209943228858 no 1299 0.377122757860186 1817 16268368 SGTC_2572 astragaloside iv 100 µM 0.312992291211984 0.391230196705601 no 1300 0.377143259425005 1773 45006101 An anti-inflammatory agent. SGTC_1778 st046819 58.9 µM 0.311972047485879 0.39161312118003 no 1301 0.377530883386968 1744 671715 SGTC_752 1896-0090 130 µM 0.31156375679693 0.391766392933438 no 1302 0.377686040966364 1747 772567 SGTC_290 2043-6722 48.1 µM 0.311164241136907 0.391916386816746 no 1303 0.377837882988809 1793 773758 YLR208W SEC13 SGTC_910 3454-3003 490 µM 0.307675823972406 0.393226755995034 no 1304 0.37916450879239 1872 820824 SGTC_1202 1988-0068 29.6 µM 0.306637363917443 0.393617071721658 no 1305 0.37955970525617 1691 2850480 SGTC_1883 5-benzylidenerhodanine 20 µM 0.306194368206308 0.393783608701702 no 1306 0.379728330069327 1893 1273210 SGTC_122 0236-0016 402.397 µM 0.306156693828301 0.393797772663715 no 1307 0.379742671749193 1772 6808838 SGTC_3070 9117005 49.47 µM 0.304783721405857 0.394314047552075 no 1308 0.380265440230482 1840 8779016 SGTC_730 1436-0052 41.2 µM 0.303651986005027 0.394739750464417 no 1309 0.380696520646894 1792 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1334 1486-0610 236 µM 0.303132349441357 0.394935254195306 no 1310 0.380894500981197 1822 3742339 SGTC_1963 st076565 50.3 µM 0.300803976324115 0.395811586095603 no 1311 0.381781988045265 1743 4914280 SGTC_797 k781-0471 270 µM 0.300239355459724 0.39602417251045 no 1312 0.381997293833453 1839 23738129 SGTC_3290 9121031 71.43 µM 0.29925095051632 0.396396393052342 no 1313 0.382374288231068 1739 17014854 SGTC_2520 obtusaquinone 4.71 µM 0.298194979677453 0.396794162390115 no 1314 0.382777176618255 1868 5967872 SGTC_2306 7482397 179.52 µM 0.298134485558232 0.396816952929327 no 1315 0.382800261005683 1886 891448 SGTC_1887 st057648 70.8 µM 0.296658999477511 0.397372936137671 no 1316 0.38336343111676 1912 688672 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.296655635098003 0.397374204120362 no 1317 0.383364715530313 1752 6708760 SGTC_835 0312-0010 67.2 µM 0.296385169271103 0.397476142061539 no 1318 0.383467975010641 1776 1626196 SGTC_1277 0873-0036 22 µM 0.296302059274262 0.397507467432817 no 1319 0.383499706726824 1859 5965735 SGTC_1663 st014140 55.4 µM 0.295662257111465 0.397748640325561 no 1320 0.383744011799014 1831 4207120 SGTC_2472 5377652 49.4 µM 0.294409769162124 0.398220877681347 no 1321 0.384222401413824 1764 1610903 SGTC_2346 9031566 143.75 µM 0.293948760836659 0.398394733582814 no 1322 0.384398528680729 1890 4771086 SGTC_1235 benzylparaben 21.5 µM 0.293495182165852 0.39856580729084 no 1323 0.38457184075899 1810 7180 SGTC_2707 st078556 66.6 µM 0.2931297885851 0.398703634904565 no 1324 0.384711474160946 1929 17250899 SGTC_2496 diffractaic acid 79.83 µM 0.292956768486936 0.39876890304117 no 1325 0.384777598179395 1914 94870 An apoptosis inducer which activates caspases. SGTC_2321 7390090 138.78 µM 0.291269476658239 0.399405546002007 no 1326 0.385422614986814 1723 649046 SGTC_96 0929-0093 37.281 µM 0.290153351891457 0.399826825400309 no 1327 0.385849460772763 1747 6991579 SGTC_3041 9091929 49.47 µM 0.289782184911827 0.399966947612039 no 1328 0.385991438876886 1851 25236887 SGTC_2808 7946468 45.46 µM 0.289543063395485 0.400057227109519 no 1329 0.386082915285163 1834 2970879 SGTC_2113 5491891 107.031 µM 0.28858089951024 0.400420542682559 no 1330 0.386451056945964 1719 789979 SGTC_1440 4100-1550 40 µM 0.288103812518561 0.400600723945813 no 1331 0.386633637167722 1874 742806 SGTC_2239 6685329 187.64 µM 0.288010709271443 0.400635888681773 no 1332 0.386669270519076 1767 805680 SGTC_2515 chrysin 20.77 µM 0.287595759235763 0.40079262349254 no 1333 0.38682809571908 1880 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1206 3978-0017 132 µM 0.286889174069607 0.401059551384991 no 1334 0.387098590031481 1869 3873677 SGTC_3092 9117248 49.47 µM 0.286392300082663 0.401247283994993 no 1335 0.387288835741598 1895 17141857 SGTC_1626 st003712 1.76 µM 0.286341353867016 0.401266534161031 no 1336 0.387308343826071 1847 24207035 SGTC_3090 9117696 49.47 µM 0.285118543015806 0.401728648372827 no 1337 0.387776662069389 1921 7923821 SGTC_666 0272-0154 136 µM 0.285009680590893 0.401769795400996 no 1338 0.387818362673705 1833 6870312 SGTC_828 2074-0507 139 µM 0.284408960551937 0.401996870767535 no 1339 0.388048496445191 1902 X828 SGTC_3044 9093193 49.47 µM 0.280689913796516 0.403403423842428 no 1340 0.389474122752668 1747 25236277 SGTC_640 3381-0960 37.1 µM 0.28010432279598 0.403625010282539 no 1341 0.3896987341478 1883 1745025 SGTC_3245 9134821 49.47 µM 0.277340332468598 0.404671315095122 no 1342 0.390759396434344 1741 17014901 SGTC_891 0929-0073 133 µM 0.275688498567494 0.405296940676364 no 1343 0.391393665117864 1895 5603632 SGTC_3249 9135183 49.47 µM 0.274224808360363 0.405851509912657 no 1344 0.3919559321418 1863 4902779 SGTC_2483 5729050 27.16 µM 0.273596853169281 0.40608949027392 no 1345 0.392197226282988 1950 2865180 SGTC_3264 9137442 49.47 µM 0.272940201153394 0.406338383179089 no 1346 0.39244959163022 1919 17015726 SGTC_2582 agaric acid 100 µM 0.272705188313767 0.40642747004678 no 1347 0.392539923063903 1760 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3069 9117009 49.47 µM 0.270387635835405 0.407306248801164 no 1348 0.393431025576361 1940 41904981 SGTC_111 0083-0039 52.457 µM 0.26902819634352 0.407821943954788 no 1349 0.393953992370464 1875 759313 SGTC_1361 1608-0041 5.61 µM 0.2688845811573 0.407876432852455 no 1350 0.394009251308467 1805 X1361 SGTC_1608 st001473 40.5 µM 0.268618885620534 0.407977244833824 no 1351 0.39411148883234 1764 7292267 SGTC_2875 9039966 71.43 µM 0.268247430192124 0.408118195153547 no 1352 0.394254434149684 1931 6463691 SGTC_2242 6630449 61.2675 µM 0.268208741064705 0.408132876589188 no 1353 0.394269323510654 1870 691249 YDR170C SEC7 SGTC_870 0573-2213 57.6 µM 0.267820896437042 0.408280059840024 no 1354 0.394418592549068 1802 3916321 SGTC_1669 st015249 58.4 µM 0.267627364035571 0.408353508338591 no 1355 0.394493082803833 1980 722793 SGTC_3229 9132204 49.47 µM 0.265235865326206 0.409261383519704 no 1356 0.395413883732732 1883 17682924 SGTC_1980 st071811 45.7 µM 0.264762087203166 0.409441299971412 no 1357 0.395596372449766 1908 4974850 SGTC_2179 6298986 200 µM 0.263795053159131 0.409808588698493 no 1358 0.395968923303981 1978 738374 SGTC_764 1951-2361 146 µM 0.263758099454785 0.40982262563909 no 1359 0.395983161643907 1764 5438930 SGTC_1579 chlormadinone acetate 49.4 µM 0.262610458471902 0.410258616870092 no 1360 0.396425419116058 1969 45114258 A steroidal progestin. SGTC_1034 k072-0165 12.7 µM 0.262312921229 0.410371670028777 no 1361 0.396540100510162 1968 5835461 SGTC_2267 7931562 200 µM 0.260964225193752 0.41088421795945 no 1362 0.397060047846166 1717 934880 SGTC_114 0364-0001 490.298 µM 0.260008089566285 0.411247672537988 no 1363 0.39742876679034 1794 4003655 SGTC_2864 9034755 47.6 µM 0.259653725706001 0.41138239577425 no 1364 0.397565445044067 2008 4930451 SGTC_727 3032-0951 202 µM 0.259598880464303 0.411403247955725 no 1365 0.39758659999553 1871 3652836 SGTC_1984 st072354 53.1 µM 0.258527640183764 0.411810584025687 no 1366 0.397999859994617 1875 5762938 SGTC_544 k015-0020 52.4 µM 0.257747845218664 0.412107158649038 no 1367 0.398300759071541 1837 3008304 SGTC_1386 3228-0095 33.8 µM 0.256440949912 0.412604314599721 no 1368 0.398805185623863 1934 870181 SGTC_333 3486-0131 40.1 µM 0.253162095033312 0.413852239160308 no 1369 0.400071478173748 1983 6744690 SGTC_653 0203-0016 55.2 µM 0.252761186704798 0.414004883916056 no 1370 0.400226381227044 1885 295302 SGTC_1613 st002381 52.1 µM 0.252482247598226 0.414111096888564 no 1371 0.400334167045947 1995 551167 SGTC_793 0488-0545 106 µM 0.249803117911463 0.415131560706355 no 1372 0.401369804216553 1819 292548 SGTC_829 1635-0120 117 µM 0.24972685652596 0.415160616610464 no 1373 0.401399293794605 1972 285054 SGTC_1196 1588-0294 184 µM 0.245434843080742 0.416796634899799 no 1374 0.403059876494951 1834 6144269 SGTC_1957 st077035 62.4 µM 0.245344073570415 0.416831249851298 no 1375 0.403095014275243 1959 705593 SGTC_105 0111-0055 734.78 µM 0.24486807628518 0.417012781960212 no 1376 0.403279290363904 1890 5179370 SGTC_2200 6600604 21.907 µM 0.244810342494472 0.417034801224207 no 1377 0.403301642703088 1873 2904777 SGTC_2652 actinonin 100 µM 0.242035562004303 0.418093388683808 no 1378 0.404376303892845 1923 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_418 lividomycin a 100 µM 0.241427700062333 0.418325369455875 no 1379 0.404611823024506 1979 72394 An antibiotic. SGTC_1030 k029-0042 36.7 µM 0.240252786742225 0.418773836768259 no 1380 0.405067146934115 1886 6080581 SGTC_905 2-aminofluorene 215 µM 0.239882591312775 0.418915163178753 no 1381 0.40521063850122 1853 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2763 lisinopril 49.32 µM 0.236760645325561 0.420107416859072 no 1382 0.406421242016377 2018 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2153 5569715 200 µM 0.235816012885188 0.42046831174846 no 1383 0.406787721024948 1908 2054701 SGTC_626 0214-0009 33 µM 0.235659657163814 0.420528053589496 no 1384 0.406848388576177 1959 3437874 SGTC_1485 3909-9022 254 µM 0.235206048517247 0.420701382933615 no 1385 0.407024405818666 1978 714516 SGTC_696 1560-0013 611 µM 0.235172507833924 0.420714199844791 no 1386 0.407037421613381 1950 1650269 SGTC_1414 3917-0015 5.4 µM 0.234583420546806 0.420939321632316 no 1387 0.407266039499941 1964 6618702 SGTC_1094 duloxetine 25.4 µM 0.234220531777159 0.421078013731146 no 1388 0.407406888118446 1900 60834 A selective serotonin reuptake inhibitor. SGTC_3192 9110362 49.47 µM 0.233945977433877 0.421182951892572 no 1389 0.407513459306259 1916 16649480 SGTC_415 dibenzyl ketone 100 µM 0.233877943559846 0.421208956170328 no 1390 0.407539868436495 1996 7593 SGTC_1759 st043059 70 µM 0.23324014694671 0.421452754963768 no 1391 0.407787466317168 1810 669426 SGTC_2877 9040724 71.43 µM 0.232997121958453 0.421545659589855 no 1392 0.407881820309595 2046 6463895 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.232926863451529 0.42157251912474 no 1393 0.407909099037953 1903 4620898 SGTC_2643 anethole 100 µM 0.232474222519245 0.421745570612941 no 1394 0.408084853137174 1910 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1215 3852-0577 11.2 µM 0.232414126812935 0.421768547249387 no 1395 0.408108188845091 1984 2884876 SGTC_2661 dactinomycin 12.96 µM 0.232185111496759 0.421856110049734 no 1396 0.408197120556918 1921 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_39 0986-0283 58.349 µM 0.230221118147061 0.422607190764684 no 1397 0.40895997632238 2004 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_923 1900-2434 73.3 µM 0.229982395699255 0.422698503503847 no 1398 0.409052724645905 1835 5910570 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.226777329895429 0.42392486035223 no 1399 0.410298446297732 1928 6708739 YPR165W RHO1 SGTC_2002 4023503 131 µM 0.226101501122998 0.424183547745609 no 1400 0.410561238546934 2091 4736863 YCR052W RSC6 SGTC_197 4544-0043 41.561 µM 0.225750171371056 0.424318039362469 no 1401 0.410697867033695 1986 896523 SGTC_3016 9080866 49.47 µM 0.225378375551239 0.424460375138737 no 1402 0.410842466363187 1906 17066299 SGTC_2682 pyrogallin 40.03 µM 0.224264770697044 0.424886758900299 no 1403 0.411275643482738 1960 822798 An ATP competetive kinase inhibitor. SGTC_2060 5238662 140 µM 0.224090590625693 0.424953457980918 no 1404 0.411343406955927 1884 790130 SGTC_22 0964-0034 14.468 µM 0.224079572729402 0.424957677155564 no 1405 0.411347693476254 1913 138402 SGTC_163 TUB2.036 7.546 µM 0.223777439470515 0.425073378905015 no 1406 0.411465242756253 2025 15992207 YJR013W GPI14 SGTC_2175 5807670 165.306 µM 0.223137403379297 0.425318501646963 no 1407 0.411714284221146 2021 241186 SGTC_2098 5376439 882.5 nM 0.221978194030004 0.425762532194198 no 1408 0.412165429260566 1991 2844116 SGTC_3348 9149464 3.537 µM 0.221972455027168 0.425764730731177 no 1409 0.41216766307452 2004 1951442 SGTC_249 wiskostatin 11.211 µM 0.221762791403105 0.425845051706968 no 1410 0.412249273196671 2004 2775510 A n-wasp and actin depolymerizer. SGTC_75 0159-0059 199.013 µM 0.221736679380741 0.425855055293971 no 1411 0.412259437387389 1992 5377270 SGTC_744 1594-0068 283 µM 0.221349960722429 0.426003213850127 no 1412 0.412409975785273 1881 668392 SGTC_2597 laccaic acid a 100 µM 0.220836122257068 0.426200090343852 no 1413 0.412610018183691 1895 5491415 A textile dye. SGTC_1332 1480-0653 17.5 µM 0.220271741740848 0.426416353149408 no 1414 0.412829763260753 2044 5749438 SGTC_2143 5623677 140.463 µM 0.219778546894893 0.426605356710019 no 1415 0.413021814123312 2005 5375313 SGTC_2044 5102272 200 µM 0.2174696393171 0.42749040643957 no 1416 0.413921182568881 1926 592666 SGTC_257 daunorubicin 18.5 µM 0.217427185557862 0.427506683232423 no 1417 0.413937723451095 2029 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3346 9158254 43.5805 µM 0.21635073865609 0.427919434676744 no 1418 0.414357180863373 1927 17639500 SGTC_1178 0988-0033 191 µM 0.215959316026488 0.428069540858231 no 1419 0.414509730164998 1970 5392207 SGTC_2894 9048625 32.47 µM 0.215817875746345 0.428123784178276 no 1420 0.414564856916284 2034 4092861 SGTC_945 3381-0768 11.3 µM 0.213984543517174 0.42882700223182 no 1421 0.415279555254124 2029 1126236 YIL048W NEO1 SGTC_2627 acetyl isogambogic acid 100 µM 0.212994981645751 0.429206666212249 no 1422 0.415665438472084 1857 6857789 A caspase activator and apoptosis inducer. SGTC_918 glabranin 770.725 nM 0.21102416361632 0.429963002325877 no 1423 0.416434208031313 1954 124049 Also referred to as licorice root. SGTC_35 0133-0054 64.071 µM 0.210918130610816 0.430003701670872 no 1424 0.416475578093027 1861 99677 SGTC_131 0141-0277 33.849 µM 0.210394241028432 0.430204800558104 no 1425 0.416679993530858 2024 1547771 SGTC_1847 st056231 15 µM 0.209199995802814 0.430663288009817 no 1426 0.417146057850224 1940 5393180 SGTC_1052 3253-3998 198 µM 0.20825721307964 0.431025301545515 no 1427 0.4175140690832 2008 5450317 SGTC_855 0428-0020 25 µM 0.207685060083082 0.431245027454368 no 1428 0.417737441830599 1925 6812414 SGTC_3257 9139206 32.98 µM 0.205631434978385 0.432033863050013 no 1429 0.418539410336101 2028 4910041 SGTC_2295 7971645 200 µM 0.205148698003928 0.432219330762222 no 1430 0.418727974974383 1986 2978226 YKL099C UTP11 SGTC_782 0083-0095 30.5 µM 0.204851045541578 0.432333696388503 no 1431 0.41884425200766 1968 3591729 An indicator and reagent. SGTC_3087 9117406 49.47 µM 0.20373450424494 0.432762750324998 no 1432 0.419280488585652 1933 42546093 SGTC_1421 4029-0249 71.4 µM 0.203687960802255 0.432780637324095 no 1433 0.419298675429393 2063 2894095 SGTC_13 0199-0087 65 µM 0.203414954327385 0.432885558561472 no 1434 0.419405356141905 2038 4589825 SGTC_3048 9093155 49.47 µM 0.203317125222503 0.43292315717603 no 1435 0.419443585536895 2065 25236002 SGTC_655 k060-0012 42 µM 0.202971898786935 0.43305584274225 no 1436 0.419578498270593 1928 5994525 SGTC_2826 7992541 19.48 µM 0.202952437569403 0.433063322761242 no 1437 0.419586103896973 2038 2985066 SGTC_818 4072-2707 53.5 µM 0.201671350230559 0.43355576788851 no 1438 0.420086830790517 1950 882871 SGTC_3079 9117512 49.47 µM 0.201086118498001 0.433780763127967 no 1439 0.420315618067096 1991 7185044 SGTC_3307 9126885 69.2785 µM 0.199000170544624 0.434582890207334 no 1440 0.421131305593031 1886 24824909 SGTC_1237 0330-0133 46.1 µM 0.198344671595064 0.434835010499888 no 1441 0.421387701505998 1934 X1237 YHR072W ERG7 SGTC_2800 7887935 81.82 µM 0.198286394826881 0.434857426397947 no 1442 0.421410497856736 1966 2961002 SGTC_1438 4092-1045 4 µM 0.195809778248734 0.435810238503917 no 1443 0.422379528147886 1982 1351342 SGTC_1391 3442-0225 151 µM 0.195695164810822 0.435854342029607 no 1444 0.422424384580707 1955 5227075 SGTC_2493 resveratrol 26.09 µM 0.19497256791417 0.436132417394595 no 1445 0.422707211554377 1942 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2246 7293507 91.5585 µM 0.194260699265702 0.436406395105584 no 1446 0.422985878420829 2092 887656 SGTC_686 1319-0111 510 µM 0.192600341914251 0.43704553712037 no 1447 0.423635988566375 2053 4562600 SGTC_1415 3966-0071 78.1 µM 0.192373468243257 0.437132883225256 no 1448 0.423724836758558 2024 2893185 SGTC_1367 1812-0510 76.9 µM 0.19197873323728 0.437284863054705 no 1449 0.423879431991751 2016 1142582 YDR527W RBA50 SGTC_1346 1488-2224 62.4 µM 0.191507316829397 0.437466378679174 no 1450 0.424064074314045 2085 3722427 SGTC_317 4495-0002 170 µM 0.190638766165382 0.437800842536719 no 1451 0.424404308071049 1935 15991618 SGTC_2945 9067681 61.76 µM 0.189083682896885 0.438399789109616 no 1452 0.425013614981874 2053 16456930 SGTC_772 k072-0172 35.3 µM 0.188439504091953 0.438647938580734 no 1453 0.425266067280746 1853 5861980 SGTC_1047 2043-3044 82 µM 0.188386826574981 0.43866823199299 no 1454 0.425286712844125 1939 669592 SGTC_940 3232-1287 54.8 µM 0.18829699426975 0.43870283923532 no 1455 0.425321920719362 2106 1585493 YIL048W NEO1 SGTC_1892 st058411 7.36 µM 0.188029306046436 0.438805966954666 no 1456 0.425426838996677 2070 3934738 SGTC_1992 st073643 23.3 µM 0.187362118502842 0.439063021094373 no 1457 0.42568836083451 1952 3161292 SGTC_1363 1636-0063 10.4 µM 0.186410378583567 0.439429752080983 no 1458 0.426061477071663 1964 6072185 SGTC_1583 clindamycin 39.6 µM 0.186204007683091 0.439509279208516 no 1459 0.426142390623023 1884 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_987 1497-1013 404 µM 0.185990693926947 0.439591484401988 no 1460 0.426226029585376 2051 1676435 SGTC_2360 9040895 200 µM 0.184929875185262 0.440000333082498 no 1461 0.426642019056325 1952 4914414 SGTC_3270 9137563 49.47 µM 0.184638260265637 0.440112735215813 no 1462 0.426756387254355 2041 17015724 SGTC_88 0180-0332 8.668 µM 0.182413484529475 0.440970426864879 no 1463 0.427629122108247 2025 3101745 SGTC_1717 st033143 58.0435 µM 0.180161625378186 0.441838841698251 no 1464 0.428512841972818 2072 674616 SGTC_353 1988-1175 58.3 µM 0.177022406239276 0.443049926882306 no 1465 0.429745394941146 1921 2788357 SGTC_780 0109-0199 192 µM 0.175631506478091 0.443586695519106 no 1466 0.430291724246795 2114 610414 SGTC_2583 asiatic acid 100 µM 0.17469797705746 0.44394701634572 no 1467 0.430658478702892 2028 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2782 7736369 71.43 µM 0.174506082806246 0.444021088852644 no 1468 0.430733875362839 1971 2950836 YOL077C BRX1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.174105753796076 0.444175624909072 no 1469 0.430891175694448 2094 688798 SGTC_963 1269-2853 151 µM 0.17112927751131 0.445324876701586 no 1470 0.432061057650418 1956 3668223 SGTC_1270 0831-1170 17.3 µM 0.169652193635866 0.445895367058072 no 1471 0.432641836441301 2083 6764716 SGTC_1199 1638-0010 4.46 µM 0.169623992226207 0.445906260310601 no 1472 0.432652926453375 1942 3111136 SGTC_2809 7964133 12.99 µM 0.169145049205744 0.446091266059748 no 1473 0.432841275624747 1994 1253665 SGTC_672 1441-0018 53.7 µM 0.168269936712786 0.446429334140932 no 1474 0.433185461817235 1985 251141 SGTC_337 1315-0038 354 µM 0.168173785216116 0.446466481175105 no 1475 0.433223281784855 2006 1626437 SGTC_1516 st013856 110 µM 0.167395774605252 0.446767073953531 no 1476 0.433529324822766 2028 5281404 A mutagen and neurotoxin. SGTC_1947 st076332 61.6 µM 0.167069040572184 0.446893320295994 no 1477 0.433657862826409 2109 24208416 SGTC_1268 0828-0275 2.46 µM 0.166990805604166 0.446923550203693 no 1478 0.433688641704483 2047 745337 SGTC_1396 3511-0007 98.6 µM 0.16678571614287 0.447002798014932 no 1479 0.433769329061762 1987 X1396 SGTC_637 1181-0519 7.26 µM 0.166343667096519 0.447173615638638 no 1480 0.433943251666716 2070 6252091 YGR060W ERG25 SGTC_2522 biochanin a 4.94 µM 0.165205180031387 0.44761359751242 no 1481 0.434391244107326 2070 5280373 A possible chelator. SGTC_167 3672-0051 66.205 µM 0.165104659524359 0.447652447963698 no 1482 0.434430802787729 2046 3237971 SGTC_2805 7950783 58.44 µM 0.162154523357125 0.448792876429986 no 1483 0.435592085429526 2039 1178958 YDL195W SEC31 SGTC_679 0422-0091 41.4 µM 0.160050223083309 0.449606590910021 no 1484 0.436420755904518 1997 627384 YHR062C RPP1 SGTC_2415 st077333 57.7 µM 0.158720626571602 0.45012084372048 no 1485 0.436944493265262 2188 2766255 SGTC_1677 st019204 53.9 µM 0.158587914391359 0.450172177898201 no 1486 0.436996775602936 1937 3945625 SGTC_2178 5812956 200 µM 0.158563605805395 0.450181580752273 no 1487 0.437006352158192 2138 5403383 SGTC_576 1073-0113 22.7 µM 0.15741897761857 0.450624368303393 no 1488 0.43745732897086 2151 5439563 SGTC_292 k038-0015 474 µM 0.156039921988638 0.451157923263381 no 1489 0.438000776710673 2104 46368540 SGTC_2145 5634607 200 µM 0.155975055577728 0.451183022180371 no 1490 0.438026341659749 2009 308662 SGTC_2699 st077704 54.6 µM 0.155676446100846 0.451298566381964 no 1491 0.438144032036863 2042 645852 SGTC_2484 5809818 12.04 µM 0.154778391776439 0.451646085102881 no 1492 0.43849801338383 2038 2870548 SGTC_3328 9140624 29.0385 µM 0.152372781188948 0.452577162447611 no 1493 0.439446461923839 2128 4904392 SGTC_409 arachidonic acid 100 µM 0.152141816156145 0.452666569901308 no 1494 0.439537541778734 2052 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_380 3970-0968 6 µM 0.151778139359666 0.452807355452711 no 1495 0.43968096231039 2042 2891601 SGTC_859 0439-0102 54.6 µM 0.151116908018848 0.453063344680375 no 1496 0.439941747499315 2160 610143 SGTC_3171 9103192 49.47 µM 0.151058702713323 0.453085879229156 no 1497 0.439964704529483 2166 13018434 SGTC_1687 st020778 55.3625 µM 0.149955886350575 0.45351286996277 no 1498 0.440399709610236 2057 4259299 SGTC_2949 9072542 2.23 µM 0.149798838918526 0.453573680297509 no 1499 0.440461662715278 2017 16457352 SGTC_1050 3232-1156 69.3 µM 0.146833685969816 0.454722019859559 no 1500 0.44163164764425 2006 700529 SGTC_99 0109-0120 622.8 µM 0.146337583972988 0.454914186647531 no 1501 0.441827448740111 2127 759414 SGTC_3043 9092303 49.47 µM 0.146329962237592 0.454917139034951 no 1502 0.441830456990869 2025 25236084 SGTC_444 curcumin 90.4 µM 0.145805787738494 0.455120191435659 no 1503 0.442037353391093 2100 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3084 9116877 49.47 µM 0.145473617912292 0.455248871987981 no 1504 0.442168472005054 2156 27241325 SGTC_2916 7875993 68.79 µM 0.144614511319224 0.455581706354146 no 1505 0.442507619652365 2192 1299250 SGTC_2862 9027634 71.43 µM 0.144595064557427 0.455589240764256 no 1506 0.442515297097001 1963 5012562 SGTC_58 0957-0393 9 µM 0.144413462451578 0.455659601050639 no 1507 0.44258699337149 2050 6997992 SGTC_2117 5521686 200 µM 0.14192663183762 0.456623242705697 no 1508 0.443568979042 2051 803312 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.141520052088704 0.456780815925145 no 1509 0.443729560092278 1995 803109 SGTC_1530 rhein 70.4 µM 0.140864087737027 0.457035054449784 no 1510 0.443988656518501 2149 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1748 st037455 53.6035 µM 0.140258450733104 0.457269802728238 no 1511 0.444227895630348 2058 580690 SGTC_1781 st038725 66.3 µM 0.138930439165541 0.457784599493021 no 1512 0.444752558619333 1972 4270275 YIL048W NEO1 SGTC_3279 9140807 49.47 µM 0.137254366507702 0.458434421332007 no 1513 0.445414869615366 2152 45595718 SGTC_2305 7443522 69.23 µM 0.13656474250536 0.458701824402392 no 1514 0.445687423369961 2087 5415886 SGTC_707 0865-0008 204 µM 0.135681528341256 0.459044319719291 no 1515 0.446036525457388 2093 723043 SGTC_2450 5739737 12.93 µM 0.134876443577247 0.459356544287228 no 1516 0.446354782321988 2068 2262825 SGTC_297 0986-0032 24 µM 0.13381574640322 0.459767937621057 no 1517 0.446774137678367 2077 2847425 SGTC_534 k292-0788 63.4 µM 0.133594946860336 0.459853580558188 no 1518 0.446861440095408 2214 4146317 SGTC_642 0335-0876 158 µM 0.133448521145515 0.459910376668359 no 1519 0.446919337101384 2069 6812350 SGTC_2837 9008476 45.46 µM 0.133276558616186 0.459977079130452 no 1520 0.446987332856768 2095 2992805 SGTC_789 1309-1135 70.6 µM 0.132775495702656 0.460171442597035 no 1521 0.447185467172635 2174 3092424 SGTC_2690 usnic acid 100 µM 0.13270092853855 0.460200368187673 no 1522 0.447214954246728 2150 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2125 5246583 200 µM 0.131148920927021 0.460802460083873 no 1523 0.447828751017029 2171 835267 SGTC_944 3370-0224 231 µM 0.130472237816979 0.461065003389194 no 1524 0.44809640869093 2060 4580514 SGTC_1956 st077085 54 µM 0.130097397270174 0.461210443436854 no 1525 0.448244684649308 2043 24208685 SGTC_2459 5811157 9.22 µM 0.129684443511088 0.461370677611291 no 1526 0.448408045450267 2194 2870684 YBR192W RIM2 SGTC_582 0987-0078 156 µM 0.129321978135838 0.46151132646934 no 1527 0.448551440710347 2178 1625765 SGTC_1072 oxiconazole 14.9 nM 0.128966832845351 0.461649139555484 no 1528 0.448691946584613 2177 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2347 9049783 174.81 µM 0.128733055273012 0.461739858769694 no 1529 0.448784439349891 2129 6467988 YPL169C MEX67 SGTC_2616 abietic acid 100 µM 0.127120822660975 0.462365552189324 no 1530 0.449422385529837 2211 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1241 0364-0022 50.8 µM 0.127021873410506 0.462403956579991 no 1531 0.449461543148283 2120 4563895 SGTC_1573 oleylamine 1.06 µM 0.126376055478409 0.462654621383276 no 1532 0.449717127567023 2096 5356789 An amine of the fatty acid oleic acid. SGTC_1527 coumarin 137 µM 0.126151886332668 0.462741632837478 no 1533 0.449805848073468 2121 323 A hepatotoxic, DNA x-linker. SGTC_3260 9137109 49.47 µM 0.125753092135601 0.462896429565554 no 1534 0.449963686979764 2185 17478346 SGTC_2698 st077697 67.5 µM 0.125477649713587 0.463003349111736 no 1535 0.450072709063547 2052 3154499 SGTC_2480 5767542 37.17 µM 0.125260578903755 0.463087612207885 no 1536 0.450158629900377 2131 2867358 SGTC_3323 9138564 53.9225 µM 0.124930582481286 0.463215714225563 no 1537 0.450289253359123 2178 43912313 YNL103W MET4 SGTC_2508 celastrol 40.54 µM 0.12460443285252 0.46334232669625 no 1538 0.450418359421686 2186 122724 Celastrol is a natural product and antioxidant. SGTC_244 nsc-207895 1.295 µM 0.124442501652061 0.463405190356803 no 1539 0.450482461704414 2138 42640 SGTC_2101 5377231 179.231 µM 0.123569814917843 0.463743993649025 no 1540 0.450827946738334 2137 2844213 SGTC_796 1234-0020 70.7 µM 0.122097208058977 0.464315763512058 no 1541 0.451411016491612 2201 46495034 SGTC_274 sirtinol 40.1 µM 0.121444411126241 0.464569248977838 no 1542 0.451669521091746 2000 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_52 0329-0193 875 nM 0.12027698854072 0.46502260285417 no 1543 0.452131866124225 2169 3739292 SGTC_2368 9071271 200 µM 0.118121564798897 0.465859753426658 no 1544 0.452985668414983 2086 27209959 SGTC_3035 9091303 49.47 µM 0.117849077777824 0.465965596196494 no 1545 0.453093621008258 2190 25237002 SGTC_732 3970-1727 52.7 µM 0.116427831855315 0.466517692923246 no 1546 0.453656739376227 2196 1275699 SGTC_3288 9119690 36.221 µM 0.115727994044384 0.466789575432331 no 1547 0.453934059637235 2080 17595618 YKL019W RAM2 SGTC_3349 9149703 23.001 µM 0.115654356980833 0.46681818386337 no 1548 0.453963240634603 2197 4910494 SGTC_1809 st050081 57.6 µM 0.115585361088946 0.466844989327563 no 1549 0.453990582647567 2164 5036894 SGTC_2934 9036370 36.88 µM 0.115487407445207 0.466883045371727 no 1550 0.454029400547629 2154 6462800 SGTC_2918 7977171 22.06 µM 0.115313977199552 0.466950425629868 no 1551 0.454098130031932 2176 2236483 SGTC_2296 7971656 126.45 µM 0.113677649729865 0.46758620981473 no 1552 0.454746665291357 2109 666570 SGTC_926 2268-1401 59.4 µM 0.11311061593619 0.467806546410433 no 1553 0.454971429354029 2217 2931578 SGTC_1339 1486-1321 22.7 µM 0.110398595339452 0.468860511928376 no 1554 0.456046633538878 2091 3469382 SGTC_3211 9128781 49.47 µM 0.109835856591479 0.469079235214007 no 1555 0.456269776810076 1953 17194361 SGTC_2860 9025725 38.96 µM 0.109246875021811 0.469308168459784 no 1556 0.456503340940847 2041 40546248 SGTC_172 1112-0046 2.638 µM 0.108638077431227 0.469544814726406 no 1557 0.456744779027163 2111 2802135 YIL048W NEO1 SGTC_2959 9079155 11 µM 0.108457249572469 0.469615106564388 no 1558 0.456816495157344 2129 16189457 SGTC_2033 5192550 145 µM 0.108353841489097 0.469655304027761 no 1559 0.456857507321932 2120 182073 SGTC_382 3229-0966 23.2 µM 0.107556373040703 0.469965311513188 no 1560 0.45717380271298 2202 5722370 SGTC_1138 3761-0006 1.03 µM 0.106819333395228 0.470251844129218 no 1561 0.457466154699695 2214 12061087 SGTC_3119 9125183 49.47 µM 0.106078864546887 0.470539725398301 no 1562 0.45775989008242 2213 22695334 SGTC_3117 9124945 49.47 µM 0.104616609987191 0.471108269344161 no 1563 0.458340017084348 2025 17592065 SGTC_401 neomycin 50 µM 0.104410862115693 0.471188271595158 no 1564 0.458421651537997 2119 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1317 1273-0028 910 nM 0.103326278718351 0.471610016186171 no 1565 0.458852009918677 2140 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2658 polymyxin b sulfate 77.05 µM 0.102860488650953 0.471791150316701 no 1566 0.45903684839975 2149 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1010 4112-3296 15.2 µM 0.102230038575598 0.472036325900626 no 1567 0.459287042659346 2238 704384 SGTC_2238 6671620 73.2395 µM 0.101233252885008 0.472423987242449 no 1568 0.459682650157931 2244 729941 SGTC_187 1488-2104 32.728 µM 0.0997500862363232 0.473000855938633 no 1569 0.460271367866711 2201 2852859 SGTC_123 0083-0120 66.675 µM 0.098906475177617 0.473328998700503 no 1570 0.460606263835016 2066 16001701 SGTC_1403 3909-7815 62.9 µM 0.0984817750334717 0.473494202874712 no 1571 0.460774871510764 2150 6615483 SGTC_467 ro 31-8220 72.8 µM 0.0965575334684372 0.474242770598857 no 1572 0.461538891115432 2243 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2865 9030313 51.95 µM 0.0964894917967407 0.474269241824568 no 1573 0.461565909658454 2180 42562754 SGTC_1621 st003705 32.4 µM 0.0955421042367858 0.474637829321676 no 1574 0.461942124426785 2233 24207032 SGTC_3226 9131256 49.47 µM 0.0949075002451678 0.474884738430164 no 1575 0.462194149539907 2233 17178073 SGTC_1456 k015-0012 13 µM 0.0942734576569525 0.475131438743591 no 1576 0.462445966858111 2258 2989616 SGTC_1120 ficusin 1.78878 µM 0.0933595086580112 0.47548706489723 no 1577 0.462808978692768 2153 6199 A DNA cross-linker. SGTC_1022 4477-0945 21.3 µM 0.0931783545397391 0.475557555996911 no 1578 0.462880935070442 2198 4648966 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0928248140600621 0.475695128668364 no 1579 0.46302136867395 2187 5377381 SGTC_1886 st057356 49.9 µM 0.0919209293283166 0.476046869100334 no 1580 0.463380431329934 2076 24207747 SGTC_2832 7992762 51.95 µM 0.0917339689189403 0.476119625776974 no 1581 0.463454703937104 2045 2985177 SGTC_1803 st050068 52.4 µM 0.091388066334397 0.476254237776928 no 1582 0.463592121877211 2260 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1567 st069303 68.4 µM 0.09048650639325 0.476605102975576 no 1583 0.463950308151052 2136 5581319 SGTC_901 1112-0062 60.1 µM 0.0904778803646027 0.476608460104134 no 1584 0.463953735380427 2249 1908457 SGTC_342 k048-0088 23.3 µM 0.090016765994205 0.476787921717025 no 1585 0.4641369457902 2216 6820570 SGTC_3280 9140961 49.47 µM 0.0890198326160749 0.477175935367703 no 1586 0.464533074272211 2087 4901226 SGTC_191 3914-0123 66.505 µM 0.0889700078427392 0.477195328099139 no 1587 0.464552872921856 2136 3144412 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0886601396131877 0.477315935806278 no 1588 0.464676005857004 2145 6857784 SGTC_1057 3448-5381 134 µM 0.0878577763525799 0.477628243321108 no 1589 0.464994858182802 2231 5497911 SGTC_1634 st006576 41 µM 0.0874542896173854 0.477785299508902 no 1590 0.465155208881396 2249 3915356 SGTC_709 3807-1509 243 µM 0.0865802194126834 0.478125540918107 no 1591 0.465502594734958 2248 1886677 YPL242C IQG1 SGTC_2019 4016004 108 µM 0.0837924189866266 0.479210828106949 no 1592 0.466610737797683 2179 45595336 SGTC_657 3534-0529 86.7 µM 0.0834771922495317 0.479333555328347 no 1593 0.466736056016452 2261 1049549 SGTC_1868 st057644 42.7 µM 0.0834592927178439 0.479340524211681 no 1594 0.466743172064649 2257 688665 SGTC_1271 0832-2808 169 µM 0.08290846943274 0.47955498112361 no 1595 0.466962159798017 2249 3663794 SGTC_2396 5342950 42.78 µM 0.0827010030087666 0.479635757403154 no 1596 0.467044643660442 2168 1886677 SGTC_756 0508-1999 28.3 µM 0.0824426069130268 0.479736364129834 no 1597 0.46714737796366 2086 6753853 SGTC_124 0136-0217 7.121 µM 0.0808001159747375 0.480375899207042 no 1598 0.467800457919171 2279 3976905 SGTC_3248 9135562 49.47 µM 0.0805851329193151 0.480459610721347 no 1599 0.467885944979909 2238 17650701 SGTC_2841 9004761 38.96 µM 0.0804921992007644 0.480495798130135 no 1600 0.467922900120602 2145 2991039 SGTC_557 1315-0110 16.2 µM 0.0802936433597044 0.480573114216444 no 1601 0.468001856878166 2259 6833801 SGTC_1832 st054113 55 µM 0.0787914269097177 0.481158088988078 no 1602 0.468599261591624 2282 1251267 SGTC_287 k060-0039 29.6 µM 0.0787841144993685 0.481160936597808 no 1603 0.468602169780951 2272 5861974 SGTC_1562 morin hydrate 59.1 µM 0.0781777830846063 0.481397058411072 no 1604 0.46884331722502 2197 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1756 st041558 35.5 µM 0.0781371540957081 0.481412880669855 no 1605 0.468859476416116 2283 3955792 SGTC_1581 himbacine 57.9 µM 0.0760378228118326 0.482230468290203 no 1606 0.469694503517078 2130 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2061 5245884 80.95 µM 0.0757655336094101 0.482336517264399 no 1607 0.469802818736787 2254 573863 SGTC_2696 st077691 74.316 µM 0.0754951588088673 0.482441821869661 no 1608 0.469910374628536 2222 757133 SGTC_784 4579-0127 173 µM 0.0743554027882023 0.482885743326188 no 1609 0.470363796971537 2275 1948547 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0742578853572583 0.482923726202474 no 1610 0.470402593542623 2220 688664 SGTC_229 benomyl 22.8748 µM 0.0740600431198188 0.483000785898931 no 1611 0.470481304440672 2182 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2525 harmine 47.85 µM 0.0738286307238897 0.48309092200231 no 1612 0.470573372581557 2228 5280953 A monoamine oxidase inhibitor SGTC_470 aa-861 153 µM 0.0730422156280487 0.483397240427273 no 1613 0.470886261997764 2172 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2775 cyproheptadine 69.59 µM 0.0725505878386797 0.483588740533046 no 1614 0.471081874114705 2294 2913 A selective serotonin reuptake inhibitor. SGTC_843 0310-0051 143 µM 0.0712325256822024 0.484102174012321 no 1615 0.471606347702927 2165 2065037 SGTC_2937 9044753 11.33 µM 0.0711351711913792 0.484140098207629 no 1616 0.471645088249154 2276 6465530 YGL099W LSG1 SGTC_194 1486-1323 56.904 µM 0.0678436554963991 0.485422382030678 no 1617 0.472955045867816 2209 5178754 SGTC_36 0335-0881 14.2 µM 0.0655195242391553 0.486327891118581 no 1618 0.473880180819806 2252 23828853 SGTC_2399 5884133 200 µM 0.0654335444932398 0.486361391227765 no 1619 0.473914408327322 2222 722445 SGTC_2987 9018338 71.43 µM 0.0651609881285605 0.486467587431021 no 1620 0.474022911024645 2309 5055682 SGTC_2337 9009472 200 µM 0.0641216659499884 0.486872547528416 no 1621 0.474436675205335 2272 5742383 SGTC_3129 9127257 49.47 µM 0.0629822225105583 0.487316534279554 no 1622 0.474890330296969 2125 837894 SGTC_817 1391-0715 46 µM 0.0618866743335812 0.487743431971341 no 1623 0.475326539748769 2225 1353946 SGTC_2965 9082772 38.63 µM 0.0618046064144901 0.487775411606792 no 1624 0.475359217557352 2298 16459634 SGTC_350 k064-0020 19.8 µM 0.0616278162204526 0.487844302202688 no 1625 0.475429612449457 2304 2790705 SGTC_2830 7992007 71.43 µM 0.0613069701373951 0.487969328601947 no 1626 0.475557369939573 2292 1952075 SGTC_464 bw-b 70c 158 µM 0.0609904106636514 0.488092685766145 no 1627 0.475683423010502 2290 5353454 SGTC_887 0885-0007 9.62 µM 0.057707310192116 0.489372112141782 no 1628 0.476990885355456 2296 5719458 SGTC_2340 7987427 183.45 µM 0.0569400739437326 0.489671120854286 no 1629 0.477296465844223 2290 2239331 SGTC_586 0957-0265 8.15 µM 0.0557748574642283 0.490125242196794 no 1630 0.477760582296971 2311 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1000 4048-0884 8.67 µM 0.0549808606477634 0.490434694983579 no 1631 0.478076855858056 2248 13040088 SGTC_2736 butenafine 14.65 µM 0.0548860612076155 0.49047164256161 no 1632 0.478114618342225 2274 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2555 cholic acid 100 µM 0.0547916169444053 0.490508451792617 no 1633 0.478152239540313 2232 6708657 Influences liver metabolism. SGTC_438 sphingosine 6.67 µM 0.0540169322242544 0.490810384734944 no 1634 0.478460836986123 2278 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_228 caffeine 993.056 µM 0.053185365644075 0.491134493206024 no 1635 0.478792107818091 2312 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1648 st011736 69.8 µM 0.0525340576678779 0.491388348814934 no 1636 0.479051579348367 2287 2855514 SGTC_1048 3161-0300 24.5 µM 0.0509445357091854 0.492007899752585 no 1637 0.479684858599245 2308 2165101 SGTC_2953 9074162 66.49 µM 0.0507386517437319 0.492088148971821 no 1638 0.479766888331236 2318 16451992 SGTC_993 3909-8757 62.7 µM 0.0503648061662376 0.492233866894655 no 1639 0.47991584069374 2268 4288324 YLR208W SEC13 SGTC_2095 5432005 200 µM 0.0503507347836721 0.492239351673328 no 1640 0.479921447249833 2311 783734 SGTC_1744 st037937 38.9 µM 0.0500466770505878 0.492357868413296 no 1641 0.480042595996602 2272 1016152 SGTC_1064 honokiol 6.76 µM 0.0494489632398636 0.492590849454528 no 1642 0.480280754418666 2240 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2854 9024559 71.43 µM 0.0492613058624471 0.492663996375765 no 1643 0.480355527753874 2271 3163529 SGTC_454 lyso-paf C-16 6.67 µM 0.0479475857754044 0.493176077763534 no 1644 0.48087900750605 2261 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2694 st077685 81.9 µM 0.0469474367936926 0.493565938318888 no 1645 0.4812775603281 2299 2838096 SGTC_769 0302-0231 76 µM 0.0467901355386532 0.493627255307323 no 1646 0.48134024556181 2303 571869 YER009W NTF2 SGTC_854 0422-0053 192 µM 0.0461353578476621 0.49388249324555 no 1647 0.481601182256941 2304 3596728 SGTC_6 0844-0013 19.835 µM 0.0457777594857363 0.494021889206339 no 1648 0.481743692791169 2326 1584900 SGTC_1313 1220-0047 237 µM 0.045711460737203 0.494047733302961 no 1649 0.481770114505989 2268 3528706 SGTC_1607 st000305 50.6 µM 0.0447630284542236 0.494417446969387 no 1650 0.482148097278142 2310 5457690 SGTC_1840 st055363 71 µM 0.0445727612673749 0.494491616668033 no 1651 0.482223927216952 2198 676033 SGTC_1433 4060-0023 7.6 µM 0.0435234972763709 0.494900642695782 no 1652 0.482642117076388 2300 3840627 SGTC_1325 1431-0015 227 µM 0.0434649442991002 0.494923468087491 no 1653 0.482665454250201 2314 1103340 SGTC_308 4092-1169 104 µM 0.043021714098759 0.495096250662605 no 1654 0.482842112264417 2302 2268590 YDL196W YDL196W SGTC_1692 fluoroquinolonic acid 71 µM 0.0424276560675398 0.495327831257161 no 1655 0.483078890920226 2287 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1680 diphenhydramine 100 µM 0.0418142350729515 0.495566961733013 no 1656 0.483323393495529 2211 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_264 promethazine 12.5 mM 0.0413065527355605 0.495764873218394 no 1657 0.483525754601504 2339 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2446 5162541 200 µM 0.0412615320255358 0.495782423841776 no 1658 0.483543699966917 2325 1549321 SGTC_9 0092-0002 10.449 µM 0.0407371368880943 0.495986851720126 no 1659 0.483752727600615 2337 759368 SGTC_161 4065-0411 162.148 µM 0.0398030587294504 0.496350991189176 no 1660 0.484125068826035 2301 1906281 YLR208W SEC13 SGTC_1124 fisetin 1.16336 µM 0.0396766227168579 0.49640028103346 no 1661 0.484175469683572 2219 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3320 9137005 35.139 µM 0.0393121918491827 0.496542351151716 no 1662 0.484320743220547 2192 4908713 SGTC_95 0471-0001 561.058 µM 0.0391886543934245 0.49659051122569 no 1663 0.484369989585847 2297 4015405 SGTC_1446 4239-0190 62 µM 0.0391837133670218 0.496592437445749 no 1664 0.484371959257335 2296 1340085 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0367932133565344 0.497524363434908 no 1665 0.48532494267162 2341 5355888 SGTC_3293 9120939 62.045 µM 0.0363733357372286 0.497688052430211 no 1666 0.485492337552544 2324 934087 SGTC_120 rhodamine 6G 52.259 µM 0.0361597024501968 0.497771337368409 no 1667 0.485577508873426 2347 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1144 3486-0183 12.5 µM 0.0358743044407416 0.497882599934988 no 1668 0.485691292380436 2259 6744069 SGTC_2455 5377712 9.75 µM 0.0358632053316534 0.497886926931983 no 1669 0.485695717436843 2212 2243908 SGTC_1439 4092-1168 46 µM 0.0352048029850355 0.498143606066567 no 1670 0.485958216189309 2320 2886240 SGTC_1693 xanthone 101.9 µM 0.0350775259128222 0.498193225314501 no 1671 0.486008961052579 2278 7020 An insecticide. SGTC_247 mechlorethamine 29.705 µM 0.0331785560077568 0.498933545825951 no 1672 0.486766099266594 2332 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3206 9114350 49.47 µM 0.0325975493322523 0.499160054300407 no 1673 0.486997762071482 2356 17087243 SGTC_2859 9028643 45.46 µM 0.0314499058508445 0.499607469806813 no 1674 0.487455370850496 2320 17151580 SGTC_1954 st077032 68.9 µM 0.0312741279360912 0.499675997909971 no 1675 0.487525461614284 2170 698907 SGTC_2733 amorolfine 100 µM 0.0310417510168925 0.499766591498098 no 1676 0.48761812160326 2352 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3009 9080819 71.4286 µM 0.0309435643040272 0.499804870203053 no 1677 0.487657273626228 2313 17027216 SGTC_2804 7954240 19.48 µM 0.0308465151871418 0.499842705410856 no 1678 0.487695972148868 2330 828705 SGTC_1293 1000-1278 195 µM 0.030039578962705 0.499842705410856 no 1679 0.4880177439774 2322 678847 SGTC_765 1319-0117 244 µM 0.0281907499579808 0.49912192844478 no 1680 0.488755007378986 2360 3487746 YGL099W LSG1 SGTC_1338 1486-1223 76 µM 0.0276388964042711 0.498906785508723 no 1681 0.488975079330511 2311 3444526 SGTC_2912 7964298 10.93 µM 0.027585450026705 0.498885949180413 no 1682 0.488996393223507 2329 2975850 SGTC_2205 7238770 200 µM 0.0265213125875597 0.498471090769768 no 1683 0.489420767295104 2353 279867 SGTC_3169 9102970 49.47 µM 0.026068740933755 0.498294654301538 no 1684 0.489601254853276 2357 17027839 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0260391035910137 0.498283100102462 no 1685 0.489613074430088 2349 2724278 An inhibitor of dopamine biosynthesis. SGTC_2680 butyl paraben 22.24 µM 0.0255659375399072 0.498098635225709 no 1686 0.489801777544866 2361 7184 An antifungal and steroid mimetic. SGTC_1649 st011737 51.3 µM 0.0254142759945598 0.49803950970647 no 1687 0.489862262094583 2319 1761035 SGTC_3210 9128157 49.47 µM 0.0250385166896921 0.497893019471228 no 1688 0.490012120677247 2241 17590849 SGTC_316 k060-0003 58.6 µM 0.024945264565618 0.497856665057192 no 1689 0.490049311275927 2349 6152314 SGTC_1911 st060208 74.3 µM 0.024706073130393 0.497763416169829 no 1690 0.490144705451416 2348 688783 SGTC_975 1335-0046 28.5 µM 0.0246003704813354 0.497722207983731 no 1691 0.490186861894359 2336 16486740 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0239957865459545 0.497486511369025 no 1692 0.490427984794983 2355 279621 SGTC_2889 9059656 51.95 µM 0.0231039629405573 0.497138836199849 no 1693 0.49078367228084 2341 3949838 SGTC_1106 tegaserod maleate 11.7 µM 0.0228741525586501 0.497049245547258 no 1694 0.49087532913508 2285 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2386 9075165 157.42 µM 0.0227837955369801 0.49701402026648 no 1695 0.490911366979341 2360 16452277 SGTC_83 0170-0301 39.027 µM 0.0226108567662485 0.496946600925329 no 1696 0.490980341797701 2364 3089716 SGTC_1604 st002052 72.4 µM 0.02210907242385 0.49675098323322 no 1697 0.491180474749137 2299 6254834 YHR062C RPP1 SGTC_1942 st076330 65.2 µM 0.0216564968808652 0.49657454997258 no 1698 0.491360983042831 2334 24208414 SGTC_1650 st011916 45.8 µM 0.0207056936580103 0.496203888523738 no 1699 0.491740213556186 2362 242528 SGTC_432 NS 1619 61.3 µM 0.0178373127477679 0.495085699102263 no 1700 0.492884319110546 2283 4552 A K+/calcium channel activator. SGTC_1909 st060837 51.5 µM 0.0145754082829936 0.493814148635853 no 1701 0.494185459258484 2364 678937 SGTC_3022 9087993 49.47 µM 0.0140707130047831 0.493617414405816 no 1702 0.494386782889707 2379 17173644 SGTC_2167 5876490 200 µM 0.0140558198010372 0.493611608939992 no 1703 0.494392723830857 2363 686534 SGTC_810 3825-7150 143 µM 0.0137261185758892 0.493483089648018 no 1704 0.494524242899365 2381 22330411 YGL099W LSG1 SGTC_222 nsc-310342 10.666 µM 0.0135763031917618 0.493424691036807 no 1705 0.494584005021531 2381 432556 SGTC_1860 st056228 74.6 µM 0.0126258799018507 0.49305421572862 no 1706 0.494963136503692 2336 688679 SGTC_3267 9137951 49.47 µM 0.0116787030191608 0.49268501183102 no 1707 0.495340977494626 2378 16643986 SGTC_1635 st007035 42.4 µM 0.0106936874442589 0.492301065288296 no 1708 0.495733917253189 2384 3716403 SGTC_1867 st057372 64 µM 0.00973168166368203 0.491926094552752 no 1709 0.496117682004607 2381 688837 SGTC_2891 9063876 19.48 µM 0.00913912855853463 0.491695132657667 no 1710 0.496354065965679 2388 6472478 SGTC_517 1365-0151 113 µM 0.00901123193844501 0.491645282221332 no 1711 0.496405087233848 2363 768657 SGTC_785 1270-0111 65.3 µM 0.00831601607057675 0.491374309307109 no 1712 0.496682427823398 2397 6741994 SGTC_260 nsc-65238 3.989 µM 0.00749350246461341 0.491053724955763 no 1713 0.497010553016126 2390 3246252 SGTC_2407 paclitaxel 400 µM 0.00703656061773692 0.490875628980664 no 1714 0.497192841626222 2351 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2300 7976697 71.57 µM 0.00686182546105236 0.490807525326965 no 1715 0.497262549184853 2383 2236109 SGTC_3167 9103034 49.47 µM 0.00654930644864588 0.490685720591142 no 1716 0.497387223428828 2393 5127859 SGTC_3188 9110789 49.47 µM 0.00640301815246068 0.490628704814473 no 1717 0.497445582791423 2387 849217 SGTC_1018 4259-0013 28.1 µM 0.00629050272550303 0.490584852123767 no 1718 0.497490469048362 2355 6801262 SGTC_1970 st070122 35.8 µM 0.00470073103192938 0.489965253800748 no 1719 0.498124686548998 2393 102928 SGTC_908 3448-7491 47.7 µM 0.00170098928194673 0.48879620027899 no 1720 0.49932140378416 2402 1203031 SGTC_1088 bifonazole 369 nM 0.00161465071808924 0.488762553958681 no 1721 0.499355847840368 2402 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3154 9100113 49.47 µM 0.00116477296698358 0.488587236950348 no 1722 0.499535322921473 2400 25237525 SGTC_1524 corynanthine 62.1 µM 0.000921094607470122 0.488492276602479 no 1723 0.499632536468791 2392 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1482 3346-2049 8.48 µM 0.000129479102541359 0.488183792172207 no 1724 0.499948345311712 2404 3826804 SGTC_2358 9037157 4 µM 8.15151551755172e-05 0.488165101339917 no 1725 0.499967480158143 2405 2388925 SGTC_1442 4112-3290 3 µM 7.87000906421893e-05 0.488164004352216 no 1726 0.499968603206404 2404 704353 SGTC_3207 9114163 49.47 µM -0.000313393929015168 0.48801121217321 no 1727 0.499874973913341 2407 849233 SGTC_2504 purpurogallin 52.29 µM -0.000708312208328434 0.487857321208344 no 1728 0.499717424336002 2408 5281571 An antioxidant. SGTC_2644 guaiazulene 100 µM -0.00339343001154328 0.486811038984804 no 1729 0.498646219891025 2405 3515 A coloring agent. SGTC_1627 st003713 25.6 µM -0.00365199858562502 0.486710289906461 no 1730 0.498543066594772 2414 16195070 YER133W GLC7 SGTC_1844 rapamycin 4 nM -0.00377529827443444 0.48666224751412 no 1731 0.498493877474966 2413 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_527 4476-4215 268 µM -0.00498455898719375 0.486191082502082 no 1732 0.498011456905357 2421 4418754 SGTC_3196 9111891 49.47 µM -0.00584751087330232 0.485854861763601 no 1733 0.497667193971962 2414 18891510 SGTC_377 3970-0964 33.1 µM -0.00714854608927518 0.485347975389557 no 1734 0.497148167010535 2418 16481235 SGTC_1130 3454-2858 15.9 µM -0.00758329085588229 0.485178603044573 no 1735 0.496974733648347 2439 715628 YIL048W NEO1 SGTC_973 1325-0077 65.9 µM -0.00844468017298772 0.484843022047387 no 1736 0.496631100075424 2432 2835149 SGTC_1967 st070177 51.4 µM -0.00860280939216431 0.484781419051501 no 1737 0.496568017935827 2422 5729214 SGTC_2260 7964312 200 µM -0.00888256668397551 0.484672433839624 no 1738 0.496456415189473 2423 231951 SGTC_521 r062-0005 13.8 µM -0.00923621491734087 0.484534664530027 no 1739 0.496315335747024 2423 2832033 SGTC_2256 7954252 200 µM -0.0105131070434493 0.484037246323222 no 1740 0.495805954360233 2448 2972920 SGTC_2552 juarezic acid 87.02 µM -0.0109509928602018 0.483866671911221 no 1741 0.495631273255242 2416 1549512 SGTC_2281 7943571 200 µM -0.0110773588006671 0.483817447763321 no 1742 0.495580863596564 2424 1244024 SGTC_532 1548-0774 215 µM -0.0123508830729666 0.483321377452684 no 1743 0.495072835810697 2440 5932993 SGTC_2289 7946404 165.07 µM -0.012394167799921 0.483304517392611 no 1744 0.495055569024666 2438 1246120 YPR165W RHO1 SGTC_2994 9053520 71.4286 µM -0.0132399986647168 0.482975059423673 no 1745 0.494718159056279 2440 4647384 SGTC_2425 5628681 7.85 µM -0.0134598263390296 0.482889436659108 no 1746 0.494630468317247 2433 5714958 SGTC_1122 capsaicin 818.572 nM -0.0142238871149084 0.482591841548521 no 1747 0.494325681375896 2459 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1092 toremifene 6.32 µM -0.0150098407303973 0.48228572948629 no 1748 0.494012164749939 2435 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_391 gliotoxin 8.33 µM -0.0159107404768895 0.481934861229715 no 1749 0.493652800713079 2454 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1873 rapamycin 2 nM -0.0160114897554139 0.481895623851008 no 1750 0.493612612685594 2442 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1405 3909-7894 12 µM -0.0166313657141428 0.481654213511619 no 1751 0.493365350897115 2448 7104060 SGTC_1198 1612-1005 86.7 µM -0.0168690294613358 0.481561657279745 no 1752 0.493270550080088 2447 6998509 SGTC_100 0086-0128 49.5915 µM -0.0178281608630125 0.481188141431533 no 1753 0.492887969603834 2439 93297 SGTC_3333 9141820 12.094 µM -0.0193561288198752 0.480593137032029 no 1754 0.492278503987458 2455 1939433 SGTC_2022 5136654 200 µM -0.0197898409936345 0.480424253449502 no 1755 0.492105511005306 2473 1713771 SGTC_3096 9117468 49.47 µM -0.0200363833872489 0.480328253644355 no 1756 0.492007174319587 2428 41316311 SGTC_2198 6589944 200 µM -0.0221149523951247 0.479518936840462 no 1757 0.49117812955339 2456 5290268 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0228803193314733 0.479220952755553 no 1758 0.490872869592375 2454 6710655 SGTC_2093 5331342 194.4 µM -0.0229855487208836 0.479179984182661 no 1759 0.490830900177535 2442 33839 SGTC_2116 5511452 16.8835 µM -0.0232362333385716 0.479082386945288 no 1760 0.490730918189174 2475 870744 SGTC_1861 st057647 17.4 µM -0.0249663858419535 0.478408833639277 no 1761 0.490040887729253 2468 688668 SGTC_319 1348-1596 45.5 µM -0.0250680753896532 0.478369247508036 no 1762 0.490000332162295 2474 5380505 SGTC_3251 9135047 49.47 µM -0.0259029977466687 0.478044233554961 no 1763 0.489667354497048 2469 17682963 SGTC_1098 clofazimine 15.1 µM -0.0263054866161264 0.47788756011869 no 1764 0.48950683937006 2514 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1226 3909-7979 35.4 µM -0.0266298292535645 0.477761308490228 no 1765 0.489377490693913 2483 6615510 SGTC_1134 3477-0009 42.5 µM -0.0280340451960332 0.477214737902662 no 1766 0.488817498835409 2474 3973534 SGTC_2485 5633444 17.78 µM -0.0289810535342037 0.476846152846363 no 1767 0.488439850668334 2481 5724239 SGTC_3342 9147791 14.508 µM -0.0291386556154469 0.47678481446415 no 1768 0.48837700307693 2453 1838168 SGTC_417 st075190 100 µM -0.032435375769466 0.475501866553587 no 1769 0.487062425768211 2451 222757 SGTC_1837 st055472 66.5 µM -0.0325496443998343 0.475457402378831 no 1770 0.487016863238229 2564 676091 SGTC_3289 9119912 71.43 µM -0.0332038267257963 0.47520285305115 no 1771 0.486756023260383 2495 17014829 SGTC_1177 0983-0204 23.6 µM -0.0352378910060366 0.474411442047413 no 1772 0.485945024163935 2483 766818 SGTC_1081 sertraline 6 µM -0.0373607767387201 0.473585580233976 no 1773 0.485098673224864 2477 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1448 4255-0083 152 µM -0.0377185352978021 0.473446413247411 no 1774 0.484956048740694 2490 5399660 SGTC_12 0849-0099 9.267 µM -0.039138813865158 0.472893961359751 no 1775 0.484389857837061 2472 6071388 SGTC_62 0180-0423 3.232 µM -0.0393037031523741 0.472829827019143 no 1776 0.484324127105354 2498 30102 YGL099W LSG1 SGTC_2919 7978188 46.38 µM -0.0396599043187351 0.472691283572741 no 1777 0.484182134113902 2463 2980291 SGTC_2051 5263410 176 µM -0.0407356626184524 0.472272890517319 no 1778 0.483753315261307 2469 227584 SGTC_998 3996-0085 177 µM -0.041168746672529 0.472104460399841 no 1779 0.483580684541255 2515 715391 SGTC_3309 9129340 25.759 µM -0.0415922068676318 0.471939777907095 no 1780 0.483411892943132 2524 17158987 SGTC_2685 mycophenolic acid 18.85 µM -0.0424150924022799 0.471619773753972 no 1781 0.483083898589634 2514 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3042 9091578 49.47 µM -0.0432836500993392 0.47128202846533 no 1782 0.482737712169117 2469 25236497 SGTC_2270 7924575 90.91 µM -0.0436480630950151 0.471140329827567 no 1783 0.482592469685151 2514 1262135 SGTC_1682 st012968 530 nM -0.0437076604493955 0.471117156292241 no 1784 0.482568716449186 2507 24207270 SGTC_614 0462-0418 107 µM -0.0441764435570758 0.470934880444285 no 1785 0.482381879518089 2483 5188303 SGTC_158 k038-0087 26.446 µM -0.0443398833196103 0.470871331970228 no 1786 0.482316740314688 2491 X158 SGTC_170 4197-0004 226 µM -0.0449053967638615 0.470651455369847 no 1787 0.48209135759516 2535 218692 SGTC_2146 5545642 200 µM -0.0449541822315889 0.47063248756922 no 1788 0.48207191464393 2479 825326 SGTC_587 k089-0003 57 µM -0.0452210411666606 0.470528733936474 no 1789 0.481965561489378 2476 9659696 SGTC_661 1304-0007 33.6 µM -0.0472147591007755 0.469753648565865 no 1790 0.481171032289691 2516 3117130 SGTC_1514 1189-1591 158 µM -0.0479964419196637 0.469449789688849 no 1791 0.480859539138756 2502 767698 YMR146C TIF34 SGTC_1021 4476-0760 85.3 µM -0.0485472747406262 0.469235678423445 no 1792 0.480640044518987 2499 746768 SGTC_3186 9110464 49.47 µM -0.0512998955014738 0.468165856541015 no 1793 0.479543275687145 2542 17018021 SGTC_877 0771-0151 33.1 µM -0.0514305408888788 0.468115086113026 no 1794 0.479491224429364 2582 6166523 SGTC_3164 9100705 49.47 µM -0.0516491913366057 0.468030116980988 no 1795 0.479404111300001 2560 17174235 SGTC_1631 benzylvanillin 81.9 µM -0.0522824699993366 0.46778402858285 no 1796 0.479151810562915 2581 75506 SGTC_2567 aureobasidin a 60 nM -0.0527115097315665 0.467617313233037 no 1797 0.478980884168344 2645 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2997 9067075 71.4286 µM -0.053210204106184 0.46742353876985 no 1798 0.478782212716876 2549 27209819 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0537723404628589 0.467205122321519 no 1799 0.478558273369721 2490 6708784 An antioxidant flavonoid SGTC_220 paclitaxel 373.376 µM -0.0540097032524794 0.46711289866032 no 1800 0.478463716724812 2521 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2429 5902844 64.44 µM -0.054317671361426 0.466993245020217 no 1801 0.478341035313207 2562 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1624 st003710 6.25 µM -0.0556675206173193 0.466468828719971 no 1802 0.47780333707827 2508 24207033 SGTC_1811 st050069 61.5 µM -0.0566770425092926 0.466076667561346 no 1803 0.477401231018003 2506 3877702 SGTC_2514 salinomycin 42.74 µM -0.0572399617897753 0.465858008942588 no 1804 0.477177022710913 2557 23682228 A polyether potassium ionophore. SGTC_1964 st076914 61 µM -0.0576454899290869 0.465700493233357 no 1805 0.477015507085164 2494 24208661 SGTC_1319 1306-0155 43.7 µM -0.0577563655470043 0.465657427731887 no 1806 0.476971347686641 2511 3122360 SGTC_1357 1503-1303 39.5 µM -0.0583299400062581 0.465434650542995 no 1807 0.476742909715925 2502 292895 SGTC_1472 k841-0093 193 µM -0.0607034061667557 0.46451290861703 no 1808 0.475797709478607 2604 X1472 SGTC_2641 levomentholum 100 µM -0.0620174635013877 0.464002672514562 no 1809 0.475274462453764 2516 16666 SGTC_1089 terbinafine 2.25 µM -0.0620521969468431 0.463989186643779 no 1810 0.475260632450587 2552 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_282 k297-0036 65.7 µM -0.0626225638924745 0.463767737580116 no 1811 0.475033530645668 2576 5061378 SGTC_3345 9148410 3.559 µM -0.0633777243739581 0.463474558379793 no 1812 0.474732862479401 2544 4903596 SGTC_2141 5621638 7.665 µM -0.0645942290210486 0.463002311332655 no 1813 0.474248539844804 2610 2856238 SGTC_1461 k072-0203 53.8 µM -0.0652521795750968 0.462746916640786 no 1814 0.473986608161167 2503 5418714 SGTC_1751 st044839 27.194 µM -0.0658671990444675 0.462508200262662 no 1815 0.473741777610949 2508 5291326 SGTC_990 3985-0011 41.3 µM -0.0665201709978405 0.462254767619656 no 1816 0.473481849570536 2586 5399565 YGL099W LSG1 SGTC_2062 5245942 200 µM -0.0670114271433108 0.462064110500301 no 1817 0.473286303052744 2505 1376160 SGTC_2925 9010536 32.5 µM -0.0685272263441135 0.461475882082257 no 1818 0.472682973762202 2565 2994177 SGTC_846 0335-0850 148 µM -0.0685487249756861 0.46146753982164 no 1819 0.472674417169817 2536 6819598 SGTC_592 k241-0073 46.5 µM -0.0685774961699726 0.461456375565447 no 1820 0.472662966070852 2538 4230158 SGTC_1185 1319-0113 81.3 µM -0.0697571515285878 0.460998653193737 no 1821 0.472193476091318 2600 4672763 SGTC_1922 5578187 25 µM -0.0702755375159792 0.460797528663318 no 1822 0.471987176296482 2574 1350412 SGTC_1736 st036774 51 µM -0.0714092234245549 0.460357713738218 no 1823 0.471536034560124 2555 1272247 SGTC_384 k007-0144 5.16 µM -0.0714238488097869 0.460352040116663 no 1824 0.471530214736015 2596 6824886 SGTC_2878 9043973 25.97 µM -0.0720933628310779 0.460092324392838 no 1825 0.471263804088158 2692 6465167 SGTC_989 1501-0895 10.3 µM -0.0728099103118529 0.459814382465728 no 1826 0.470978692301167 2517 2830112 SGTC_1212 0520-0165 585 µM -0.0735321009716301 0.459534271473304 no 1827 0.470691350163548 2726 5403258 SGTC_1729 st035615 45.989 µM -0.0758776816992733 0.458624646905967 no 1828 0.469758206542462 2680 17385451 SGTC_2115 tiliquinol 12.7705 µM -0.0760766436295168 0.458547498659746 no 1829 0.46967906098144 2615 71208 A bioactive hydroxyquinoline. SGTC_1557 sumaresinolic acid 42.3 µM -0.0774169297049629 0.458027838459246 no 1830 0.469145936621825 2522 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1933 st074711 15.9 µM -0.0775166076853394 0.457989193834308 no 1831 0.46910629000137 2533 17250958 SGTC_820 1582-0060 59.9 µM -0.0775176508467675 0.457988789408247 no 1832 0.469105875088631 2576 3848840 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.077642042334972 0.457940564049512 no 1833 0.469056399177613 2577 1273210 SGTC_1071 trifluoperazine 6.31 µM -0.0786154625509074 0.457563200025268 no 1834 0.46866924413406 2657 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2180 6301957 200 µM -0.0790748042815788 0.457385141126139 no 1835 0.468486562008287 2551 845462 SGTC_1735 st034310 56.75 µM -0.0793709868279238 0.45727033366997 no 1836 0.468368772488108 2770 871153 SGTC_791 1348-1292 225 µM -0.0798838075783623 0.457071560489423 no 1837 0.468164834174371 2636 5437054 SGTC_1073 triclabendazole 3.09 µM -0.0808044303241637 0.456714747165908 no 1838 0.467798742352398 2589 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2904 7225135 42.03 µM -0.0809001941713539 0.456677633183515 no 1839 0.467760662773405 2614 4446116 SGTC_1174 0739-0097 51.1 µM -0.0815054972818027 0.456443052273682 no 1840 0.467519976613898 2589 728447 SGTC_2703 st077852 53.4 µM -0.0828749876212301 0.455912372193971 no 1841 0.466975471297691 2645 6281836 SGTC_2963 9082507 9 µM -0.0829696579116299 0.455875690173841 no 1842 0.466937832941637 2646 16459611 SGTC_2269 7935389 174.42 µM -0.083589300017365 0.455635605945374 no 1843 0.466691487255517 2541 97605 SGTC_2371 9071574 200 µM -0.0836424514710911 0.455615012833708 no 1844 0.466670356890314 2539 45596039 SGTC_1874 staurosporine 7.6 µM -0.084206066124011 0.455396652127788 no 1845 0.466446297625589 2628 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2753 fluvastatin 17.09 µM -0.0850040411642381 0.45508751645162 no 1846 0.466129088977904 2629 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_447 ml7 120 µM -0.0862434177819612 0.454607435711902 no 1847 0.465636458430536 2591 4216 Selective myosin light chain kinase inhibitor. SGTC_2580 diallyl disulphide 81.36 µM -0.0862588034182736 0.454601476398977 no 1848 0.465630343238291 2603 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1659 st012954 42.1 µM -0.0890898010752351 0.453505122404904 no 1849 0.464505271363545 2662 24207262 SGTC_2905 7799065 20.05 µM -0.0894599355886866 0.453361807265229 no 1850 0.464358196321076 2620 1296806 SGTC_2853 9015042 58.44 µM -0.0896961043828901 0.453270366483365 no 1851 0.464264355858597 2560 6457456 SGTC_1820 st053765 18.6 µM -0.0898395795560055 0.453214816399321 no 1852 0.464207347702684 2634 3690829 SGTC_2776 terbinafine 19.92 µM -0.0904988085121513 0.452959590826138 no 1853 0.463945420369539 2546 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_189 3970-0742 2.116 µM -0.0906968242188351 0.452882931308788 no 1854 0.46386674706935 2577 2891807 SGTC_760 0568-0725 82.9 µM -0.0908990620548645 0.452804639054959 no 1855 0.463786397740223 2648 3916171 SGTC_475 α-linolenic acid 10 µM -0.0911469883010798 0.452708661968507 no 1856 0.463687898367847 2751 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1822 st052468 42 µM -0.0923311664557611 0.452250281714601 no 1857 0.463217463436659 2593 2873678 SGTC_3306 9127676 59.7925 µM -0.0923756878152599 0.452233049301882 no 1858 0.463199777567791 2624 41905287 SGTC_2208 7283366 200 µM -0.0943039184276998 0.451486796209211 no 1859 0.462433868667089 2578 898663 SGTC_849 0386-0493 241 µM -0.095542103981226 0.451007690724266 no 1860 0.461942124528274 2579 726119 SGTC_2240 6690706 185.951 µM -0.0973666348912754 0.450301834096034 no 1861 0.461217620150603 2558 805876 SGTC_3135 9127742 49.47 µM -0.0981610524890512 0.449994546590643 no 1862 0.460902204334023 2670 3643468 SGTC_1248 0469-0687 58.6 µM -0.0985919731120654 0.449827875346374 no 1863 0.46073112174891 2656 4017482 SGTC_1694 st024011 44.9 µM -0.0991819205626631 0.449599710149637 no 1864 0.460496914686902 2593 2787533 SGTC_3261 9137475 49.47 µM -0.0998530426476671 0.449340170510188 no 1865 0.460230498246781 2570 17027690 SGTC_3072 9116419 49.47 µM -0.100128274878217 0.449233737606164 no 1866 0.460121244010005 2640 17170162 SGTC_51 1013-0126 23.419 µM -0.100819774607271 0.448966349285774 no 1867 0.459846764478548 2591 1627850 SGTC_3142 9086498 49.47 µM -0.101592145394359 0.448667717243803 no 1868 0.459540207129325 2617 25236367 SGTC_1272 0839-0021 27 µM -0.103040605335182 0.448107758354326 no 1869 0.458965372026969 2671 5027250 SGTC_3151 9099821 49.47 µM -0.103486809933315 0.447935281277925 no 1870 0.458788308717547 2699 17174189 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.105650653079469 0.447099003956041 no 1871 0.45792976713274 2602 140250 A respiratory chain inhibitor. SGTC_84 0443-0269 128.823 µM -0.105879659849107 0.44701051162143 no 1872 0.457838916215106 2584 6150058 SGTC_3105 9121040 49.47 µM -0.106502456366326 0.446769865201739 no 1873 0.457591853298272 2566 41448907 SGTC_1004 4084-0029 199 µM -0.107929764180874 0.446218432471309 no 1874 0.45702570331149 2668 716894 YLR208W SEC13 SGTC_502 l-744,832 89.3 µM -0.109204531303677 0.445726020905324 no 1875 0.456520133173166 2624 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2262 9014885 67.46 µM -0.109877193709033 0.445466221451928 no 1876 0.456253384897705 2648 6457424 SGTC_1917 st066507 28.5 µM -0.110822559562489 0.445101136546849 no 1877 0.455878527799661 2589 3156428 SGTC_1389 3405-0187 19 µM -0.110867029803242 0.445083964007866 no 1878 0.455860895394688 2645 799890 SGTC_378 3970-0959 8.33 µM -0.111492430738868 0.444842471367049 no 1879 0.455612933787227 2708 6615653 SGTC_1891 st059073 26.2 µM -0.112279863721414 0.44453844071132 no 1880 0.455300753628848 2651 688754 SGTC_3124 9127567 49.47 µM -0.11246629517728 0.444466463638123 no 1881 0.45522684635484 2661 17592030 SGTC_1381 2324-0066 62.1 µM -0.113221954125762 0.444174739163848 no 1882 0.454927295352967 2714 10885928 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.113226952867545 0.444172809484639 no 1883 0.454925313885301 2608 364106 SGTC_1289 0976-0073 69.1 µM -0.113955241929819 0.443891680050265 no 1884 0.454636637002733 2729 3391136 SGTC_2781 5567276 71.43 µM -0.114099684693633 0.443835926539069 no 1885 0.454579386085396 2765 2853274 SGTC_143 4032-1194 15.74 µM -0.114470609573738 0.443692758214403 no 1886 0.45443237169493 2575 1806963 SGTC_711 k292-0785 179 µM -0.115817232830706 0.443173055051266 no 1887 0.453898696300897 2598 4146315 SGTC_3067 9117431 49.47 µM -0.118026162688681 0.442320773426939 no 1888 0.45302346396781 2669 17150885 SGTC_1862 st057513 3.81 µM -0.118837862857401 0.442007658244016 no 1889 0.452701905498731 2640 5393163 SGTC_1691 st019933 84.6 µM -0.119188581751801 0.441872378831999 no 1890 0.452562976302997 2601 6176082 SGTC_1002 4049-0206 172 µM -0.119202232786453 0.441867113487212 no 1891 0.452557568877983 2638 4662749 SGTC_1365 1672-3266 55.4 µM -0.119220541995492 0.441860051452673 no 1892 0.452550316278538 2650 6415873 SGTC_2581 avocatin a 64 µM -0.119340398280498 0.441813822210134 no 1893 0.452502839488966 2679 6710728 A skin care supplement. SGTC_739 1486-1183 203 µM -0.119865954673511 0.441611121521679 no 1894 0.452294667107575 2613 4346692 SGTC_1046 2001-0062 216 µM -0.12051913980162 0.441359217304916 no 1895 0.452035959390705 2617 739778 SGTC_2874 9043904 71.43 µM -0.121920755329656 0.440818757227961 no 1896 0.451480888938161 2718 4463428 SGTC_2976 9009005 19.48 µM -0.12272407848442 0.440509047085355 no 1897 0.451162798060491 2667 2993148 SGTC_2774 tamoxifen 10.92 µM -0.122905586568861 0.440439074184574 no 1898 0.451090930864264 2609 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2517 totarol 10 µM -0.123004535406755 0.440400929354374 no 1899 0.451051753253859 2681 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2084 5306078 60.6385 µM -0.123280302566449 0.44029462388584 no 1900 0.450942569058535 2700 679340 SGTC_1603 st002045 67.8 µM -0.123391209353716 0.440251871646971 no 1901 0.450898658899513 2640 5887985 SGTC_138 0850-0259 40.9225 µM -0.123413178656084 0.440243403024623 no 1902 0.450889960895739 2638 6813004 SGTC_1190 1486-1332 13 µM -0.123752966532259 0.440112426690974 no 1903 0.450755436360109 2605 4150046 SGTC_492 tmb-8 126 µM -0.124512999474681 0.439819484336482 no 1904 0.450454554191409 2606 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1382 3002-2117 298 µM -0.1245807366343 0.439793377744983 no 1905 0.450427739754816 2680 1497314 SGTC_1722 st034304 3.6505 µM -0.126182925195464 0.43917595452356 no 1906 0.449793563522948 2653 4036148 YLR033W RSC58 SGTC_1652 st011932 78 µM -0.126264670382697 0.439144456956561 no 1907 0.449761210670902 2638 1551076 SGTC_1881 5652484 16 µM -0.126536883868843 0.439039572061993 no 1908 0.449653477285692 2676 2255129 SGTC_2922 7999257 32.47 µM -0.126936872632893 0.438885462632578 no 1909 0.449495181269731 2621 2988377 SGTC_2704 st078022 71.1 µM -0.127858817863953 0.438530286844169 no 1910 0.449130351031031 2746 54697681 SGTC_2529 gangaleoidin 93.61 µM -0.128312554115971 0.438355504888166 no 1911 0.448950815241358 2655 4565183 SGTC_558 k064-0027 21.3 µM -0.128454128049596 0.438300972209665 no 1912 0.448894798959016 2730 5088526 SGTC_2465 5809242 33.21 µM -0.12961025730924 0.437855688227474 no 1913 0.44843739377374 2633 2731748 SGTC_1476 4112-3294 3.34 µM -0.132011487457435 0.436931104821676 no 1914 0.447487602797607 2752 704369 SGTC_2840 9008771 71.43 µM -0.132486326206367 0.436748310815622 no 1915 0.447299818896151 2797 2992978 SGTC_2886 9058944 51.95 µM -0.132504975551768 0.436741131835786 no 1916 0.447292443903068 2621 4949929 SGTC_2144 5628481 200 µM -0.132660140711797 0.436681402528261 no 1917 0.44723108363679 2643 2818399 SGTC_1170 0310-0127 64.8 µM -0.132848374484781 0.436608945720209 no 1918 0.447156648039727 2718 774975 SGTC_776 4476-4378 112 µM -0.133045878982458 0.436532922619519 no 1919 0.447078548407091 2740 2892008 SGTC_1108 betulinic acid 729.144 nM -0.133232599243269 0.436461052724877 no 1920 0.447004715095805 2657 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2074 5212007 75.395 µM -0.133246929763493 0.436455536897098 no 1921 0.446999048567753 2639 758611 SGTC_205 1486-1330 71.903 µM -0.133369820483792 0.436408236675844 no 1922 0.446950455960152 2629 4118834 SGTC_103 0844-0104 51.839 µM -0.133712144567412 0.436276482094148 no 1923 0.446815100715208 2779 5375804 SGTC_2349 9023730 187.07 µM -0.134025158348116 0.436156014725668 no 1924 0.446691340212002 2737 4126287 SGTC_885 0865-0106 16.8 µM -0.135712620478165 0.435506675581232 no 1925 0.446024235166727 2646 2793380 SGTC_1450 4112-4260 37.6 µM -0.13629347281466 0.435283202454029 no 1926 0.445794641837727 2625 1633175 SGTC_2142 5622915 118.518 µM -0.136687996158793 0.435131428041897 no 1927 0.445638709073993 2679 5322196 SGTC_224 benfluorex 43.875 µM -0.138138620194037 0.43457345060167 no 1928 0.445065431922873 2647 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3046 9092212 49.47 µM -0.138163740112495 0.434563789457765 no 1929 0.445055505703398 2628 25236637 SGTC_1772 st048439 82.2 µM -0.13830234126552 0.434510484028707 no 1930 0.445000737615591 2715 2927068 YDL195W SEC31 SGTC_889 0919-1524 82.7 µM -0.138769688821048 0.434330752876582 no 1931 0.444816073505214 2716 3905452 SGTC_3110 9122132 49.47 µM -0.139118706044184 0.4341965377076 no 1932 0.444678173339326 2796 918317 SGTC_718 1130-0073 349 µM -0.139179702841416 0.434173082063301 no 1933 0.444654073586735 2771 6740020 SGTC_3194 9111903 49.47 µM -0.139955209709217 0.433874889698909 no 1934 0.444347689731912 2809 17087251 SGTC_1219 1469-0211 33.1 µM -0.141195592602337 0.43339802481543 no 1935 0.443857713894757 2680 6822282 SGTC_906 1165-0455 526 µM -0.143160139973752 0.432642953714399 no 1936 0.443081854595123 2647 3252859 SGTC_1983 st071813 46.9 µM -0.143368460864066 0.432562900236372 no 1937 0.442999595104712 2721 11838595 SGTC_684 1140-0066 328 µM -0.143610073028166 0.432470057066571 no 1938 0.442904192995015 2720 6813534 SGTC_269 exalamide 29 µM -0.144303464419089 0.432203631539791 no 1939 0.442630421365763 2693 3316 A derivative of salicylamide. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.144947393783721 0.431956238679177 no 1940 0.442376203349565 2647 97141 SGTC_2046 4110841 106 µM -0.145240134828446 0.431843778568693 no 1941 0.442260639432094 2712 44119630 YMR134W ERG29 SGTC_11 0438-0307 1.3 µM -0.145469142267947 0.431755806364665 no 1942 0.442170238735856 2768 4011476 SGTC_3036 9090181 49.47 µM -0.145833921945159 0.431615684841243 no 1943 0.442026248163999 2648 25236586 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.146010209952035 0.431547971037269 no 1944 0.441956664216514 2801 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_376 3970-0862 59.1 µM -0.146058807006215 0.43152930482665 no 1945 0.441937482427437 2762 3135186 SGTC_2872 9044037 25.97 µM -0.14616521984809 0.431488432008307 no 1946 0.441895480589824 2643 6465195 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.146454949294115 0.431377151611266 no 1947 0.441781125813867 2666 16486 A toxic proline analog. SGTC_807 1315-0151 48 µM -0.147774749275451 0.430870306814893 no 1948 0.441260268840302 2700 4011080 SGTC_2817 7995342 71.43 µM -0.147974743496337 0.430793512641417 no 1949 0.441181350277875 2667 18879975 SGTC_2640 pentamidine 10.38 µM -0.148137293784853 0.430731098190202 no 1950 0.441117208969354 2763 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2812 7970281 58.44 µM -0.148543506172522 0.430575132345017 no 1951 0.440956926904561 2795 2233435 SGTC_1298 1079-1278 263 µM -0.148817726635899 0.430469851114779 no 1952 0.440848731283522 2696 2840950 SGTC_3209 9113616 49.47 µM -0.149922093419661 0.430045902616004 no 1953 0.440413040344982 2748 16649353 SGTC_1512 0259-0544 12.2 µM -0.150207241467243 0.429936451983528 no 1954 0.440300556425683 2683 18476 SGTC_2833 9001315 45.46 µM -0.152190429332331 0.429175378675569 no 1955 0.43951837116041 2722 2989378 SGTC_1214 0358-0031 63.7 µM -0.153977249368596 0.428489889313552 no 1956 0.438813837007173 2976 4301366 SGTC_1301 naphtanilide LB 4.81 µM -0.156101342573466 0.42767529041255 no 1957 0.437976570058411 2781 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_617 3770-0098 35 µM -0.156180746788363 0.427644844508371 no 1958 0.437945276167347 2694 5962639 SGTC_1519 esterone 74 µM -0.156996871549246 0.42733194334895 no 1959 0.437623656834954 2673 698 A steroid. SGTC_3330 9141424 71.43 µM -0.157010985758447 0.427326532381228 no 1960 0.437618095053932 2818 27261020 SGTC_1662 st014054 52 µM -0.157936620402541 0.426971701503961 no 1961 0.437253370640529 2665 2838777 SGTC_2279 7948423 32.93 µM -0.158722618500477 0.42667044498579 no 1962 0.436943708547651 2678 1247112 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.159646933459968 0.42631622926476 no 1963 0.436579602773243 2817 521171 SGTC_738 1315-0003 72.4 µM -0.160217135169443 0.426097746345573 no 1964 0.436355015921393 2826 6251474 SGTC_961 1252-1571 372 µM -0.160470610123229 0.42600063019057 no 1965 0.436255185655585 2815 6813498 SGTC_3114 9122766 49.47 µM -0.160477285929254 0.425998072489169 no 1966 0.436252556466482 2739 17176985 SGTC_2518 prenyletin 46.28 µM -0.162208557959382 0.425334875672918 no 1967 0.435570810387187 2749 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2035 5154463 94.595 µM -0.163241569076257 0.424939261524897 no 1968 0.435164118879707 2802 2769623 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.163308576927357 0.424913602012379 no 1969 0.435137740574892 2918 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1043 0916-0009 19.3 µM -0.16421927133274 0.424564898725797 no 1970 0.434779265363216 2700 3101130 SGTC_2149 5554786 194.827 µM -0.166701322657461 0.423614826088897 no 1971 0.433802532385298 2705 745063 YPR165W RHO1 SGTC_3172 9105863 49.47 µM -0.166770771272334 0.423588249101347 no 1972 0.433775208858004 2744 2348785 SGTC_63 0099-0242 26.702 µM -0.166886532072634 0.423543949878201 no 1973 0.433729665191802 2771 3898502 YLR359W ADE13 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.167114000256288 0.423456905404863 no 1974 0.433640175155147 2698 442882 SGTC_935 2996-0153 430 µM -0.167678178260146 0.423241029464533 no 1975 0.433418232166735 2738 23738523 SGTC_589 1227-0070 34.1 µM -0.168621601851474 0.422880091265692 no 1976 0.433047144024239 2815 2841384 SGTC_1256 0570-0116 285 µM -0.170364760045883 0.422213358393366 no 1977 0.43236164218924 2749 410638 SGTC_2054 5233173 129 µM -0.171407951161729 0.421814459297138 no 1978 0.431951501590613 2840 6889 SGTC_1337 1486-1011 40.3 µM -0.171482303324718 0.421786031312235 no 1979 0.431922272118616 2707 X1337 SGTC_2030 5175110 200 µM -0.171957185618038 0.421604473294514 no 1980 0.43173559423349 2831 2831986 SGTC_10 0279-0212 42.575 µM -0.174430110196141 0.420659289645864 no 1981 0.430763726256871 2733 39851 YBR002C RER2 SGTC_1336 1486-0901 104 µM -0.174556155222635 0.420611125812537 no 1982 0.430714201299307 2799 5006114 SGTC_1026 k007-1105 30.6 µM -0.174835270589601 0.420504475569171 no 1983 0.430604536617203 2715 7066794 SGTC_3156 9099931 49.47 µM -0.175487293146853 0.420255359889656 no 1984 0.430348377226508 2716 18111053 SGTC_588 3970-1144 52.9 µM -0.175574925178228 0.420221881098807 no 1985 0.430313951557872 2856 1888707 SGTC_1068 loratadine 26.9 µM -0.175798291499865 0.420136549223857 no 1986 0.430226205960013 2761 3957 A H1 histamine antagonist. SGTC_897 1000-0139 31.4 µM -0.175923519444439 0.420088710460789 no 1987 0.430177013833998 2865 6151020 SGTC_3076 9116187 49.47 µM -0.176399537895457 0.419906875774268 no 1988 0.429990033839155 2832 27241210 SGTC_2563 tomatine 8.54 µM -0.177055589934928 0.419656297932802 no 1989 0.429732362408745 2706 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_713 1488-1073 324 µM -0.177888487711759 0.419338221134575 no 1990 0.429405276061705 2707 3312542 SGTC_2541 muurolladie-3-one 83.07 µM -0.178361214494127 0.419157714103336 no 1991 0.429219653602633 2895 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3038 9091290 49.47 µM -0.179379587838296 0.418768914046983 no 1992 0.428819828988041 2852 25236843 SGTC_2788 5282734 71.43 µM -0.181342195088705 0.41801984336751 no 1993 0.428049494065982 2868 743706 SGTC_646 4092-0839 27.3 µM -0.18294474305308 0.417408417299886 no 1994 0.427420687702572 2854 877796 SGTC_369 0957-0393 4.5 µM -0.183049315670935 0.417368526244289 no 1995 0.427379661980084 2791 6997992 SGTC_2225 6654152 15.4 µM -0.183834146597128 0.417069165920522 no 1996 0.427071783758115 2721 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1430 4049-0248 69.1 µM -0.18560752317943 0.416392919069532 no 1997 0.426376276721474 2852 22774488 SGTC_983 1491-0821 12.2 µM -0.186411921384516 0.416086257001341 no 1998 0.426060872184611 2886 46495113 SGTC_2639 lactacystin 53 µM -0.187076171221319 0.415833062427389 no 1999 0.425800455464244 2866 3870 A proteasome inhibitor. SGTC_3064 1327-0027 10 µM -0.187319372902685 0.415740369071645 no 2000 0.42570511722084 2742 16000455 YPR107C YTH1 SGTC_1327 1436-0082 2.18 µM -0.188500089060454 0.415290420220594 no 2001 0.425242322853698 2771 15992205 SGTC_2423 st077119 87.2 µM -0.188560877516592 0.415267257877914 no 2002 0.425218498948424 2678 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_555 4296-0685 37 µM -0.188893819657945 0.41514040151695 no 2003 0.425088018788825 2714 2908540 YHR072W ERG7 SGTC_1263 0774-1208 64.8 µM -0.19038113607539 0.414573818024794 no 2004 0.424505239285499 2858 906585 SGTC_1359 1582-0056 520 nM -0.190929948993162 0.414364796138734 no 2005 0.424290237936805 2848 3661189 SGTC_856 0433-0016 11.3 µM -0.191119358319618 0.414292662984035 no 2006 0.424216040717199 2822 3911780 SGTC_208 k072-0098 12.366 µM -0.191349352346396 0.414205077758466 no 2007 0.424125948884504 2746 5948901 SGTC_3029 9088683 49.47 µM -0.191450619178308 0.414166515160333 no 2008 0.424086282526524 2883 25236615 SGTC_3159 9100096 49.47 µM -0.193901808084949 0.413233351135411 no 2009 0.423126383961022 2683 25236875 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.193973486108034 0.413206070764874 no 2010 0.423098321304316 2849 5379071 SGTC_2231 micatex 6.853 µM -0.194677278311066 0.412938232529034 no 2011 0.422822800424014 2768 20737 An antifungal of unknown mechanism. SGTC_336 4111-0029 111 µM -0.194808389464649 0.41288834076955 no 2012 0.422771477139186 2799 3131175 SGTC_1825 st052143 62.6 µM -0.195582601594534 0.412593758349748 no 2013 0.422468439594498 2909 674173 SGTC_395 anisomycin 6.25 µM -0.197430996572731 0.411890656050285 no 2014 0.421745137600219 2813 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2327 6189656 200 µM -0.198715673745055 0.411402150147286 no 2015 0.421242581329256 2872 5349088 SGTC_715 0868-0130 184 µM -0.198862052188019 0.411346497601064 no 2016 0.42118532728379 2897 2876258 SGTC_611 3453-1652 23.7 µM -0.200353551247834 0.410779537017039 no 2017 0.420602041819225 2848 1560575 SGTC_866 0495-0101 262 µM -0.200456847578474 0.410740278074102 no 2018 0.42056165182048 2756 635694 SGTC_2986 9022445 71.43 µM -0.201232637646344 0.410445458855823 no 2019 0.420258336146985 2968 6459286 SGTC_1793 st048256 72.231 µM -0.202223617344242 0.410068935928312 no 2020 0.419870955281943 2733 672022 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.202779436368895 0.409857788647163 no 2021 0.419653715709225 2917 5282362 SGTC_2984 9022109 38.96 µM -0.203441157274183 0.40960644492154 no 2022 0.419395116753851 2817 6459207 SGTC_1618 st003135 44.5 µM -0.204024860851614 0.409384765616497 no 2023 0.419167035677272 2698 1270615 SGTC_318 1488-0629 67.2 µM -0.204209987944716 0.409314463982807 no 2024 0.419094703282961 2848 3662576 SGTC_2972 9093619 59.92 µM -0.205532754314129 0.408812231162873 no 2025 0.418577955031624 2784 25236256 SGTC_2677 mitomycin C 100 µM -0.206730035536231 0.408357772044496 no 2026 0.418110349550814 2788 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2314 7727897 200 µM -0.208107500565184 0.407835071961893 no 2027 0.417572515384366 2784 900724 SGTC_710 3448-4187 58 µM -0.208218424890967 0.40779298716015 no 2028 0.417529211437786 2797 3946412 SGTC_23 0213-0011 39.996 µM -0.208733823804924 0.407597458253233 no 2029 0.417328017058873 2925 627608 SGTC_368 fentichlor 4.58 µM -0.208846345113345 0.407554773662598 no 2030 0.417284095406075 2852 7329 A pesticide. SGTC_2087 5276107 200 µM -0.20986618801863 0.407167949702361 no 2031 0.416886056289951 2766 144405 SGTC_2203 7227154 166.4 µM -0.211331676275844 0.40661225212347 no 2032 0.416314233478347 2778 896304 SGTC_2839 9003951 25.97 µM -0.213168565043087 0.405915989043461 no 2033 0.415597743107697 2766 2990634 SGTC_204 PMA1.184 62.41 µM -0.213303087576821 0.40586501064527 no 2034 0.415545282716612 2748 2252213 YGL008C PMA1 SGTC_819 1013-0258 27.7 µM -0.21331584158104 0.405860177495425 no 2035 0.415540309055149 2796 5753198 SGTC_3157 9099274 49.47 µM -0.213945210019849 0.405621695180295 no 2036 0.415294891936313 2848 17217662 SGTC_490 phenamil 164 µM -0.213997201737942 0.405601995876202 no 2037 0.415274619663793 2880 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_669 0108-0021 26.2 µM -0.21525826331393 0.405124261665426 no 2038 0.414782983942859 2775 17201 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.218616944956222 0.403852566997566 no 2039 0.413474225956513 2809 77254 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.221533608970947 0.402749056426245 no 2040 0.4123384852213 2775 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_15 0266-0086 27.098 µM -0.224106434357776 0.401776278520086 no 2041 0.411337242959332 2874 1712902 YIL048W NEO1 SGTC_3001 9076041 71.4286 µM -0.224846982829767 0.401496391736812 no 2042 0.411049157364928 2789 16004211 SGTC_354 2783-3500 4.88 µM -0.225649614899751 0.40119309781432 no 2043 0.410736974395031 2827 6740761 SGTC_217 ketoconazole 989 nM -0.225738438248321 0.401159537420913 no 2044 0.410702430110191 2876 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2310 7668677 200 µM -0.225815577118492 0.401130392400852 no 2045 0.410672430597313 3026 2197143 SGTC_1960 st011366 51.8 µM -0.228036953147552 0.400291336902645 no 2046 0.409808756390164 2784 3972846 SGTC_2383 9036125 200 µM -0.228721177924256 0.400032984821262 no 2047 0.409542816731992 2809 79580 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.229079119458636 0.399897849375642 no 2048 0.409403711114318 2841 2374 Ca(2+)-ATPase inhibitor. SGTC_2895 9054447 58.44 µM -0.230133404017314 0.399499889799099 no 2049 0.408994054379185 2825 2697450 SGTC_1227 3909-8010 46.6 µM -0.231352726207835 0.399039763866041 no 2050 0.408520393969868 2837 15982272 SGTC_2979 9012552 45.46 µM -0.23157286902531 0.39895670524708 no 2051 0.408434891055835 2919 17100905 SGTC_443 clozapine 122 µM -0.232480049727924 0.398614479496952 no 2052 0.408082590396521 2789 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1753 st043925 64 µM -0.232780875212378 0.398501012988194 no 2053 0.407965782192488 2927 670181 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.232872533161951 0.398466442796535 no 2054 0.407930193746357 2748 4000243 SGTC_326 k292-0812 17.5 µM -0.233738893370122 0.398139721243275 no 2055 0.407593845716797 2884 3579357 SGTC_107 0358-0022 2.6945 µM -0.234192706526425 0.3979686078183 no 2056 0.407417688473454 2889 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_554 4483-2211 187 µM -0.23420832420288 0.397962719413252 no 2057 0.407411626472689 2921 747107 SGTC_1725 st036284 20.55 µM -0.234828344328725 0.397728969137631 no 2058 0.407170983603065 3059 707914 SGTC_184 1494-0393 24.714 µM -0.236098848104851 0.397250098481502 no 2059 0.406677983873443 2795 3090647 SGTC_2717 st081029 62.2815 µM -0.236394859209991 0.397138549967739 no 2060 0.406563142461918 2921 5292846 SGTC_2884 9058502 51.95 µM -0.236925422447405 0.39693863413618 no 2061 0.406357323573641 2931 6471554 SGTC_3308 9128332 17.569 µM -0.237026904886342 0.396900398712694 no 2062 0.406317958916635 2986 17332805 YDL196W YDL196W SGTC_1428 4049-0204 61.7 µM -0.237540127511301 0.396707047593439 no 2063 0.406118896298201 2919 X1428 SGTC_311 1315-0136 58 µM -0.238133577217405 0.396483503442685 no 2064 0.40588874642069 2989 6759207 SGTC_1017 4239-0030 168 µM -0.238343462789121 0.396404450642893 no 2065 0.405807357011649 2843 1149593 SGTC_1675 st018485 24.5 µM -0.238707137945032 0.396267483521057 no 2066 0.405666340731959 2898 3323024 SGTC_192 3455-0609 60.9 µM -0.239103087310651 0.396118375863111 no 2067 0.40551282393727 2953 3769639 SGTC_2216 7189485 200 µM -0.240664638280227 0.395530471218497 no 2068 0.404907524026892 2936 731273 SGTC_953 1188-0045 9.7 µM -0.24101374898986 0.395399067807131 no 2069 0.404772230215411 2944 6144426 SGTC_2795 7780010 54.55 µM -0.241735850084268 0.395127310554043 no 2070 0.404492424441336 2968 953673 SGTC_504 lovastatin 124 µM -0.242568368263178 0.394814061974828 no 2071 0.404169893950896 2855 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_729 4092-0585 94.1 µM -0.243612818812916 0.394421166544795 no 2072 0.403765349693912 2810 2169061 SGTC_3080 9117754 49.47 µM -0.245884999692687 0.393566801969349 no 2073 0.402885627965702 3050 9550191 SGTC_1976 st070609 63.5 µM -0.245984029095005 0.393529577461468 no 2074 0.402847297831797 2767 682556 SGTC_1117 retinoic acid 1.10837 µM -0.246989098677376 0.39315183345764 no 2075 0.402458330380071 2998 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2191 5911152 200 µM -0.248461267665715 0.392598717079174 no 2076 0.401888767269985 2895 2875902 SGTC_2571 chrysanthemic acid 100 µM -0.248714053178676 0.392503763483974 no 2077 0.401790988751439 2898 2743 An insecticide. SGTC_2357 9067248 200 µM -0.249925245954761 0.392048893100261 no 2078 0.401322579593043 2928 9150235 SGTC_971 1315-0384 26.7 µM -0.251379736033058 0.391502845973101 no 2079 0.40076026655327 2874 6769120 SGTC_3037 9091026 49.47 µM -0.251860643994232 0.391322349653514 no 2080 0.40057439032726 2946 25236398 YIL048W NEO1 SGTC_2315 7733312 200 µM -0.252235836999357 0.391181546945864 no 2081 0.400429389727681 2869 726316 SGTC_1796 st049173 110.4 µM -0.253834700187704 0.39058168446897 no 2082 0.399811632162008 2920 94134 SGTC_450 aminopyrene 156 nM -0.253986335652444 0.390524807275472 no 2083 0.399753057303286 2959 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2257 7960413 200 µM -0.254354960928696 0.390386548791772 no 2084 0.399610671440078 2855 2974689 YIL048W NEO1 SGTC_381 3461-2219 42.7 µM -0.254369659848656 0.390381036026839 no 2085 0.39960499408543 2975 2883159 SGTC_1846 st056244 14.8 µM -0.255567993853485 0.389931680391908 no 2086 0.399142217499721 2927 5393182 SGTC_2018 5133068 143 µM -0.256009018536879 0.38976634034374 no 2087 0.398971936770307 2822 785362 SGTC_763 3453-1109 128 µM -0.256877426130779 0.389440832876619 no 2088 0.398636698659802 3001 1560353 SGTC_2827 7993847 71.43 µM -0.257179702424087 0.389327548054981 no 2089 0.398520026132398 2965 2985692 SGTC_2336 9001819 198.65 µM -0.257380776269221 0.389252196329465 no 2090 0.39844242072298 3083 2989602 SGTC_1630 st005209 31.3 µM -0.259703230479923 0.388382167190995 no 2091 0.397546350280885 2871 3367314 SGTC_1490 4089-0339 670 nM -0.259835434305592 0.388332658284442 no 2092 0.397495358407298 2923 742542 SGTC_2737 bleomycin 30.5 nM -0.260665468265002 0.388021861006872 no 2093 0.397175248977249 2882 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3302 9125395 16.351 µM -0.263765616702286 0.386861679398013 no 2094 0.395980265221406 2911 17599668 SGTC_3057 9095946 49.47 µM -0.26387043083236 0.386822471962346 no 2095 0.395939880558442 2833 24540043 SGTC_2996 9066192 71.4286 µM -0.264130112516093 0.386725338767567 no 2096 0.395839830566541 2917 6472854 SGTC_3024 9090631 49.47 µM -0.265119539968626 0.386355311313972 no 2097 0.395458687531555 2977 25236383 SGTC_389 tpck 16.7 µM -0.265653908657505 0.386155510318974 no 2098 0.395252881850377 2945 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1962 st076595 64.5 µM -0.266233145281954 0.38593896725497 no 2099 0.395029828820367 2866 279619 SGTC_1497 4476-2978 41.3 µM -0.267952648473733 0.385296354042063 no 2100 0.394367883648401 2958 1528379 SGTC_495 decylubiquinone 155 µM -0.268011356150087 0.385274419340809 no 2101 0.394345288735664 2954 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3301 9125354 19.7965 µM -0.268654775465352 0.385034045366511 no 2102 0.394097678279829 2842 41905162 SGTC_3003 9075612 71.4286 µM -0.269960823976252 0.384546256753385 no 2103 0.39359519643521 2952 6501993 SGTC_1904 st060225 78 µM -0.27076086285899 0.384247544994563 no 2104 0.393287481358516 2881 66595 SGTC_1938 st074717 56.4 µM -0.271721786899415 0.383888854164865 no 2105 0.3929179739218 2837 17250979 SGTC_3021 9087658 49.47 µM -0.271873347603803 0.383832289113864 no 2106 0.392859702560615 2938 25237042 SGTC_526 4469-0568 170 µM -0.27211920344429 0.383740536767164 no 2107 0.392765182147082 2875 2901964 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.27335317691669 0.383280121699247 no 2108 0.392290870968905 2903 368090 SGTC_1547 harmine 94.2 µM -0.273584787907089 0.383193722316637 no 2109 0.392201862811537 2913 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3058 9093861 49.47 µM -0.27384243280378 0.383097618159624 no 2110 0.392102856444514 3063 17217477 SGTC_758 0868-0029 16 µM -0.276314592627604 0.38217584402827 no 2111 0.391153224381508 3001 762687 SGTC_2930 9013230 14.89 µM -0.276735227710342 0.382019071541141 no 2112 0.390991710011356 3036 2995857 SGTC_273 hydroxyurea 18.1 mM -0.278100018925833 0.381510541362854 no 2113 0.39046779060568 2880 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2528 xanthyletin 44.79 µM -0.278827863303742 0.381239425303942 no 2114 0.390188465146613 2885 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2971 9092186 9.93 µM -0.279251980907485 0.38108147183992 no 2115 0.390025727299707 2847 25236400 SGTC_1181 1222-0449 220 µM -0.279966873311618 0.380815270420085 no 2116 0.389751460109237 3080 658318 SGTC_1239 0337-0584 35.4 µM -0.282535884768157 0.379859125037346 no 2117 0.38876631741189 3084 914301 YML130C ERO1 SGTC_628 1636-0253 16 µM -0.283180356470541 0.379619377806264 no 2118 0.388519292791889 2984 4456143 SGTC_3202 9113761 49.47 µM -0.283591957301401 0.379466284104603 no 2119 0.388361550659554 3068 4798415 SGTC_2007 4011539 71.82 µM -0.284335073461096 0.379189932134791 no 2120 0.388076805051637 2886 45595301 SGTC_3013 9080133 71.4286 µM -0.284461097135677 0.379143072240932 no 2121 0.388028521540718 3120 17050193 SGTC_2836 9010338 19.48 µM -0.286240472871267 0.378481629600806 no 2122 0.387346973540536 2925 2994051 SGTC_777 1315-0167 517 µM -0.286618988526035 0.378340970814748 no 2123 0.3872020367242 3005 4221767 SGTC_597 k018-0003 82.8 µM -0.287347926732584 0.378070138243376 no 2124 0.386922964488469 3027 6786234 SGTC_1267 0828-0272 9.49 µM -0.288216867826995 0.377747366728488 no 2125 0.386590368860611 3051 745334 SGTC_648 0375-0473 33.3 µM -0.288395655518549 0.377680965930958 no 2126 0.386521946461972 2921 1713139 SGTC_2139 5578692 56.4705 µM -0.288911279456757 0.377489486194111 no 2127 0.386324635939817 3010 650991 YMR113W FOL3 SGTC_2218 6965428 192.983 µM -0.289584467122902 0.377239539636291 no 2128 0.386067075753952 2976 675684 SGTC_1128 3448-9350 235 µM -0.290338611802229 0.376959595773927 no 2129 0.385778601214698 3003 619386 SGTC_1243 0416-0003 5.65 µM -0.292214757597938 0.376263437967907 no 2130 0.385061214445755 2953 2141977 SGTC_1163 k060-0048 49.9 µM -0.292873388202149 0.37601914350245 no 2131 0.384809465266755 2923 6809982 SGTC_2576 guaiol 23.12 µM -0.293055674172638 0.37595154009087 no 2132 0.38473979845279 3033 227829 SGTC_930 2810-3379 265 µM -0.296423825862967 0.374703098947773 no 2133 0.383453216041624 3135 1015764 SGTC_3028 9087778 49.47 µM -0.296686346074316 0.374605848000329 no 2134 0.383352991099672 2918 17217395 SGTC_618 k072-0232 33.2 µM -0.297682506231955 0.374236891796699 no 2135 0.382972748228576 3014 5872756 YGL099W LSG1 SGTC_294 k038-0071 157 µM -0.297765941260879 0.37420599448618 no 2136 0.382940905474898 2987 24152826 SGTC_2445 5742597 35.57 µM -0.29790374258288 0.374154966246998 no 2137 0.3828883157045 2934 1774255 SGTC_2678 equilin 100 µM -0.298202537559683 0.374044329153398 no 2138 0.382774292580705 3027 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1470 k295-0292 231 µM -0.298558791709824 0.37391242977342 no 2139 0.382638355745273 3037 5045612 SGTC_3152 9099253 49.47 µM -0.299202068649442 0.373674300606467 no 2140 0.382392935500457 3004 25236131 SGTC_3086 9117350 49.47 µM -0.301015293634229 0.373003338197761 no 2141 0.381701416221757 2907 2679265 SGTC_1131 3454-3128 32.3 µM -0.303223537833133 0.372186723722891 no 2142 0.380859756156215 3091 710982 SGTC_486 niguldipine 82 µM -0.303331110318787 0.372146957781258 no 2143 0.380818769858687 2936 1236 A calcium channel blocker. SGTC_705 1124-0212 310 µM -0.303990924268049 0.371903076528616 no 2144 0.380567402777944 3079 9554485 SGTC_1518 st038567 90.8 µM -0.304418231327523 0.371745162171758 no 2145 0.380404639947879 2964 77966 SGTC_1213 1315-0166 115 µM -0.304739494458643 0.371626451309172 no 2146 0.380282283580424 3052 768401 SGTC_1588 farnesol 29.9 µM -0.304856181598433 0.371583336930358 no 2147 0.380237845048039 2945 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.304961556886627 0.3715444035176 no 2148 0.380197715821574 3149 165506 SGTC_3269 9137823 49.47 µM -0.305553523365331 0.371325711823636 no 2149 0.37997230595368 2917 17682936 SGTC_2401 5128683 200 µM -0.30559615690945 0.371309963206735 no 2150 0.379956073462869 2972 708373 SGTC_2669 eugenol 100 µM -0.307669312027504 0.370544410574412 no 2151 0.379166986585849 3015 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_157 1348-1695 65.819 µM -0.307974446760094 0.370431776853273 no 2152 0.379050888229218 2936 5380510 SGTC_836 0330-0104 1.35 µM -0.309168662039814 0.369991065639451 no 2153 0.378596615478612 2960 46494820 SGTC_2898 9056270 58.44 µM -0.309654389595514 0.369811862344789 no 2154 0.37841189539947 2949 19154699 SGTC_1786 berberine 21.6 µM -0.311143800246451 0.369262538726393 no 2155 0.377845652368935 2939 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3161 9100388 49.47 µM -0.311829033972735 0.369009900755299 no 2156 0.377585228767529 2980 25236368 SGTC_2532 xanthone 78.9 µM -0.31253849480385 0.368748390138416 no 2157 0.377315656263653 3058 7020 An insecticide. SGTC_2079 5212404 121 µM -0.312780443088805 0.368659220745066 no 2158 0.377223737287261 3094 758462 SGTC_1060 3448-7350 82 µM -0.313542335394959 0.368378473586334 no 2159 0.376934330973028 3088 570178 SGTC_733 4069-0007 56.1 µM -0.314056896840401 0.368188904291788 no 2160 0.376738912879453 2987 5717425 YNL287W SEC21 SGTC_1003 4049-0218 100 µM -0.314519510435163 0.368018500467239 no 2161 0.376563250288469 3113 295161 SGTC_1292 0kpi-0043 232 µM -0.314822913913073 0.367906755824064 no 2162 0.376448056479247 2997 3333905 SGTC_2050 5263056 171 µM -0.316057869845948 0.367452032343547 no 2163 0.375979291911014 3123 763468 YGL055W OLE1 SGTC_3250 9135583 49.47 µM -0.316241417658799 0.367384463994262 no 2164 0.375909636432078 3099 7699353 SGTC_149 3970-0822 46.1 µM -0.316254797731063 0.367379538629499 no 2165 0.375904558919511 3000 3114250 YBL034C STU1 SGTC_3139 9095020 49.47 µM -0.31698133112677 0.367112125768239 no 2166 0.375628883985151 2858 25236292 SGTC_45 0kpi-0036 14.9 µM -0.317010316394129 0.367101458588233 no 2167 0.375617887167028 3102 2795021 SGTC_508 roscovitine 141 µM -0.317033924018809 0.367092770568156 no 2168 0.375608930665521 2950 160355 A CDKinase inhibitor. SGTC_1033 k072-0102 21.3 µM -0.317103726557411 0.367067082407408 no 2169 0.375582448658411 3141 5965931 SGTC_2124 5246320 200 µM -0.318318574397571 0.36662009941903 no 2170 0.375121648092524 3050 579342 SGTC_1829 berberine 14.4 µM -0.318437792644498 0.366576244788588 no 2171 0.375076437339669 3141 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2134 5324836 1.464 µM -0.318645935474035 0.366499683278138 no 2172 0.374997508117411 2977 699272 SGTC_1981 st071826 47 µM -0.318954982877924 0.366386015676795 no 2173 0.374880324829471 3046 11838600 SGTC_1653 st012112 65 µM -0.319742663015007 0.366096360034979 no 2174 0.374581707864579 3139 720429 SGTC_3055 9094636 49.47 µM -0.32052139579424 0.365810069621593 no 2175 0.37428655684902 3149 25236176 SGTC_3340 9146634 11.102 µM -0.321268493203633 0.365535479736714 no 2176 0.374003465328152 3058 4907387 SGTC_413 propylparaben 100 µM -0.32134731948176 0.365506511762516 no 2177 0.373973600290071 2953 7175 A pharmaceutical preservative. SGTC_1176 0848-0131 83.3 µM -0.321738763366994 0.365362670892654 no 2178 0.373825304528335 3051 6769040 SGTC_213 1246-0773 967 nM -0.321914621711638 0.36529805574434 no 2179 0.373758687910291 3006 6251622 SGTC_2750 bromebric acid 70.15 µM -0.322618481152531 0.365039476897381 no 2180 0.373492097813266 3130 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_212 3807-4682 38.772 µM -0.322776485054534 0.364981438982963 no 2181 0.373432261401862 3039 3125501 YBL034C STU1 SGTC_1831 st055328 12 µM -0.324001831408894 0.364531450473993 no 2182 0.372968323849281 3117 1103068 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.324262477879235 0.364435756347339 no 2183 0.372869662269625 2948 15053 SGTC_917 harmaline 728.087 nM -0.32503922783714 0.364150629355571 no 2184 0.372575691349809 3070 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2964 9083345 53.42 µM -0.327156853238204 0.363373680180788 no 2185 0.37177462643992 3033 17741579 SGTC_1429 4049-0205 9.46 µM -0.327587091889791 0.363215895713841 no 2186 0.371611941521529 3011 22774478 SGTC_909 3448-9333 149 µM -0.328041987928815 0.363049093711081 no 2187 0.371439957911801 2965 3344074 SGTC_80 0159-0065 512.242 µM -0.328887377985863 0.36273917375222 no 2188 0.371120407500545 2953 1548079 SGTC_265 mycophenolic acid 32.932 µM -0.32918897765159 0.362628629073693 no 2189 0.371006426824006 3248 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2174 5790901 200 µM -0.330824945938696 0.362029200838617 no 2190 0.370388358379735 3075 786020 SGTC_2614 arthonioic acid 13.39 µM -0.331024414430189 0.361956137537247 no 2191 0.370313022072996 2944 6710684 SGTC_3258 9138477 49.47 µM -0.332855228878124 0.361285763920436 no 2192 0.36962178315542 3027 4970355 SGTC_2271 7849410 118.62 µM -0.3342704528702 0.360767855097186 no 2193 0.369087742268093 3126 972430 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.336227594637024 0.36005204925664 no 2194 0.368349622737667 3058 676296 Flavone; oxidizing agent. SGTC_1208 2323-2347 50.3 µM -0.336565412671857 0.359928545111864 no 2195 0.368222266580228 3153 5412760 SGTC_1466 k213-0079 57.5 µM -0.337316155282955 0.359654130715383 no 2196 0.367939291237745 3003 3657981 SGTC_1842 st055362 61.2 µM -0.338542513574618 0.359206023066586 no 2197 0.367477197571198 2998 676032 SGTC_1211 1056-0033 32.3 µM -0.338615155546307 0.359179485975532 no 2198 0.367449831977217 3144 6741922 SGTC_152 4469-0003 551.229 µM -0.338761463409937 0.35912603980386 no 2199 0.367394717102564 3001 697280 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.338764333643174 0.359124991337012 no 2200 0.36739363589924 3099 7104 SGTC_426 0988-0037 14.6 µM -0.339263988380291 0.35894248874717 no 2201 0.36720543434397 3208 5383008 SGTC_751 0833-0568 350 µM -0.339442785073231 0.358877189751012 no 2202 0.367138095956201 3101 6954252 SGTC_2940 9060638 45.86 µM -0.340559819372601 0.358469326988241 no 2203 0.366717491237011 3102 4027022 SGTC_2155 5570423 76 µM -0.343502849425154 0.357395512174697 no 2204 0.365610098782149 3018 797402 SGTC_2911 7942208 15.64 µM -0.345201623783336 0.356776198271522 no 2205 0.364971399054833 3089 1243384 SGTC_1929 genistein trimethyl ether 50.5 µM -0.345868242262855 0.356533275410377 no 2206 0.364720868185686 3201 136420 SGTC_1926 methyl fluorone black 53.6 µM -0.346495105267565 0.356304892951072 no 2207 0.364485331047522 3037 72721 Reacts with homocysteine. SGTC_2420 aureobasidin a 50 nM -0.346646689193852 0.356249674727051 no 2208 0.364428382669258 3275 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1309 pyrazolanthrone 13.4 µM -0.346874638117968 0.356166644323425 no 2209 0.364342750452804 3122 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2673 kobusone 100 µM -0.346880121490139 0.3561646470889 no 2210 0.364340690630374 3030 6710676 An epoxy ketone and protein crosslinker. SGTC_2226 7298446 200 µM -0.347696961336571 0.355867169762944 no 2211 0.364033889477847 3112 3283010 SGTC_2076 5212012 200 µM -0.347933621549468 0.35578099905995 no 2212 0.363945017299611 3004 604802 SGTC_3254 9136651 49.47 µM -0.348201016237828 0.355683646447518 no 2213 0.363844612316824 3055 16454030 SGTC_1406 3909-7906 11.9 µM -0.349671808536466 0.355148331264808 no 2214 0.363292506574048 3059 X1406 SGTC_664 1222-0054 14.9 µM -0.351341703673426 0.354540896266501 no 2215 0.362666005816793 3050 6813991 SGTC_3006 9075424 71.4286 µM -0.35136518656748 0.354532356846968 no 2216 0.362657198268727 3046 7465181 SGTC_2456 5770359 74.46 µM -0.352148818725661 0.354247435468107 no 2217 0.362363329097 3181 3118787 SGTC_717 1532-0246 73.2 µM -0.352512210028826 0.354115337436304 no 2218 0.362227081569019 3080 9561992 SGTC_2603 homopterocarpin 100 µM -0.353029529488251 0.353927314563623 no 2219 0.362033151348299 3129 101795 A weak amylase inhibitor. SGTC_1114 scopoletin 1.73284 µM -0.353223126414891 0.353856959751065 no 2220 0.361960585771283 3162 5280460 A coumarin with genotoxic properties. SGTC_1491 4138-0063 26.5 µM -0.35403344152274 0.353562538350054 no 2221 0.361656910739484 3105 23883227 SGTC_936 3005-4620 401 µM -0.354445698045929 0.353412781900968 no 2222 0.361502446222119 3224 777207 SGTC_2223 6903751 107.57 µM -0.355258007912277 0.353117768356338 no 2223 0.361198155550825 3111 5598863 SGTC_2621 lithochol-11-enic acid 100 µM -0.355650841986151 0.35297513108512 no 2224 0.361051031685106 3151 6708711 SGTC_2596 sinensetin 100 µM -0.356662930962117 0.352607738807143 no 2225 0.360672079766752 3060 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2168 5727979 200 µM -0.356706624931904 0.352591880816763 no 2226 0.360655722707663 3032 695210 SGTC_2635 hydroquinidine 100 µM -0.359663690900309 0.3515192601328 no 2227 0.359549323931332 3000 442912 An experimental heart treatment. SGTC_1238 0333-0287 48.8 µM -0.360299275340701 0.351288867633555 no 2228 0.359311670587771 3055 7226 SGTC_2649 anisomycin 9.56 µM -0.362549465945876 0.350473637455174 no 2229 0.358470732785342 3102 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2105 5350118 200 µM -0.363313456576636 0.350197004680313 no 2230 0.3581853711281 3068 2133313 SGTC_577 r071-0003 38.6 µM -0.365081454860627 0.349557136481447 no 2231 0.357525301891766 3046 4568517 YMR134W ERG29 SGTC_1571 st070080 73.4 µM -0.365205067708436 0.349512414878925 no 2232 0.357479167848094 3197 4315245 SGTC_2319 6033012 152.6 µM -0.365544789371357 0.349389518534252 no 2233 0.357352389700787 3044 847246 SGTC_2013 4024628 200 µM -0.365757887983873 0.349312436892496 no 2234 0.357272873081889 3194 5230760 SGTC_831 k061-1017 217 µM -0.366667197366927 0.348983593032076 no 2235 0.356933638783133 3121 1240153 SGTC_1040 k898-0338 155 µM -0.366916630324596 0.348893407570527 no 2236 0.356840603065232 3242 20969351 SGTC_827 3253-0474 693 µM -0.367709272988095 0.348606874841995 no 2237 0.356545012713627 3181 5402065 SGTC_1700 st030840 7.9285 µM -0.367827692766431 0.348564074636465 no 2238 0.356500859293371 3156 5499307 SGTC_421 streptovitacin 30 mM -0.368341892855586 0.348378250769132 no 2239 0.356309159472018 3213 91467 include heat shock SGTC_2693 st077581 40.7 µM -0.369663256926613 0.347900897447393 no 2240 0.355816706078857 3195 25238761 SGTC_144 4161-2749 112.381 µM -0.370254913976611 0.347687234670071 no 2241 0.35559628190537 3087 797501 YMR168C CEP3 SGTC_480 am 92016 50 µM -0.371441314991819 0.34725894014573 no 2242 0.355154429058623 3129 2129 K+ channel blocker. SGTC_2617 dihydrotanshinone i 20.83 µM -0.37217586093644 0.346993864427326 no 2243 0.354880958715788 3034 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2158 5657123 3.6195 µM -0.372846182427744 0.34675203071752 no 2244 0.354631464269619 3072 2858827 SGTC_3103 9120822 49.47 µM -0.372982931797378 0.346702702938571 no 2245 0.354580573647549 3278 17141819 SGTC_1709 st033179 39.1045 µM -0.373074772335373 0.34666957598305 no 2246 0.354546397088718 3048 573381 SGTC_929 2805-0021 398 µM -0.373500140867437 0.346516160506307 no 2247 0.354388120252923 3132 3098024 SGTC_2058 5236698 133 µM -0.373580667575435 0.346487120186429 no 2248 0.35435815962385 3080 766665 SGTC_2620 irigenin 100 µM -0.373949409830512 0.34635415231738 no 2249 0.354220977527446 3223 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2510 benzyl isothiocyanate 8.31 µM -0.376895128744804 0.345292611758079 no 2250 0.353125770822727 3073 2346 DNA damaging agent; causes G2/M arrest. SGTC_2104 5389443 200 µM -0.377103153644925 0.345217692271892 no 2251 0.35304847382824 3241 2244536 SGTC_1484 3473-2379 286 µM -0.377934038795569 0.344918512227816 no 2252 0.352739797614365 3150 671917 SGTC_346 4513-0042 7.16 µM -0.378282433692888 0.344793093156451 no 2253 0.352610396739609 3025 2827372 SGTC_181 1447-1644 8.07 µM -0.378325772347631 0.34477749281775 no 2254 0.35259430108355 3166 534600 SGTC_2085 5307070 144.047 µM -0.378598805665268 0.344679216828326 no 2255 0.352492904596874 3046 2840351 SGTC_1991 st073000 8.92 µM -0.379375436239234 0.344399732672722 no 2256 0.352204544333792 3259 4301969 YIL048W NEO1 SGTC_590 k048-0076 22.4 µM -0.380407546675469 0.344028441064113 no 2257 0.351821456762642 3181 6832814 SGTC_882 0843-0131 351 µM -0.382770869803155 0.343178825446221 no 2258 0.350944831051082 3215 5425421 SGTC_2549 cedrol 20.94 µM -0.383262819698872 0.343002068720634 no 2259 0.350762451970761 3211 6708665 A sedative which affects the nervous system. SGTC_2706 st078239 82.5 µM -0.383474974117044 0.342925852613356 no 2260 0.350683811221245 3105 15434492 SGTC_1838 st055369 84.5 µM -0.383867273752728 0.342784936486434 no 2261 0.350538411649433 3099 676036 SGTC_1123 mangostin 811.285 nM -0.385724460612509 0.342118122174731 no 2262 0.349850372599121 3125 5281650 An antioxidant. SGTC_345 1362-0200 395 µM -0.385769197807061 0.342102065554022 no 2263 0.349833804710408 3079 1419823 SGTC_1184 1269-1718 139 µM -0.385946885429511 0.342038294531687 no 2264 0.349768003033029 3224 5403821 SGTC_2424 5537928 59.2 µM -0.386405833066486 0.341873601828386 no 2265 0.349598065402245 3090 5382802 SGTC_2908 7930301 100 µM -0.38715193411211 0.341605928758572 no 2266 0.349321865873268 3083 2223178 SGTC_660 4031-1742 102 µM -0.390338340550683 0.340463663346609 no 2267 0.34814318785104 3128 6738706 SGTC_289 k017-0060 526 µM -0.394539707132178 0.338959789861884 no 2268 0.346591308781239 3108 5512909 SGTC_130 0136-0219 337.655 µM -0.395044469634382 0.338779282791017 no 2269 0.34640503471059 3057 234244 SGTC_2618 avocadyne 43.43 µM -0.395351412940845 0.338669535529325 no 2270 0.346291780627428 3080 3015189 SGTC_315 k915-0449 187 µM -0.395876484404129 0.33848182853065 no 2271 0.34609807480426 3151 20970215 YNL149C PGA2 SGTC_1818 st052136 56.3 µM -0.396627301725934 0.338213489702465 no 2272 0.345821158297478 3197 674169 SGTC_2754 granisetron 64.02 µM -0.396744798204226 0.338171504406137 no 2273 0.345777830694401 3230 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3060 1327-0027 12.5 µM -0.397032156215253 0.338068830564175 no 2274 0.34567187403936 3147 16000455 YPR107C YTH1 SGTC_2138 5575593 77.673 µM -0.397305326790597 0.33797123709998 no 2275 0.345571159882159 3120 762213 SGTC_977 1348-1378 135 µM -0.397830425215932 0.337783669979342 no 2276 0.345377594166435 3071 X977 SGTC_2728 chlorpromazine 9.18 µM -0.397899896319717 0.337758857657335 no 2277 0.345351988235116 3099 2726 A thorazine and dopamine antagonist. SGTC_78 0336-0123 156.75 µM -0.398297061591646 0.337617019520668 no 2278 0.345205613098106 2980 6765896 SGTC_1225 1216-0074 20.6 µM -0.398504311684272 0.337543014232441 no 2279 0.345129240333174 3123 4241466 SGTC_2066 5222451 176 µM -0.398649840988945 0.337491052084263 no 2280 0.345075615777244 3101 2281147 SGTC_2974 9094440 9.66 µM -0.398718361203763 0.337466587585995 no 2281 0.345050368564356 3261 25236134 SGTC_3344 9148862 3.898 µM -0.400038785528999 0.336995276787309 no 2282 0.344563974948272 3245 4905352 SGTC_1250 0485-0349 40.2 µM -0.400270068845667 0.336912749081236 no 2283 0.344478805471123 3123 6842794 YDL195W SEC31 SGTC_370 0180-0345 38.7 µM -0.403235840964689 0.335855183962503 no 2284 0.343387367735332 3011 3989527 SGTC_962 1254-0300 21.5 µM -0.406089041240496 0.334838985970568 no 2285 0.342338588761314 3081 7340576 SGTC_451 chloral hydrate 100 µM -0.406328699114596 0.334753684142994 no 2286 0.34225055054263 3215 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_414 piperonyl butoxide 100 µM -0.40664030460491 0.334642786631104 no 2287 0.342136095217664 3112 5794 A potent inhibitor of cytochrome P450. SGTC_2350 9023895 38.85 µM -0.412123829760924 0.332693618466098 no 2288 0.340124331605767 3260 2997209 SGTC_965 1291-5240 308 µM -0.412359973805135 0.332609779961197 no 2289 0.340037798094904 3252 2834598 SGTC_3078 9116413 49.47 µM -0.412916121898578 0.332412363113385 no 2290 0.339834034394576 3058 17177322 SGTC_403 arphamenine a 50 µM -0.414157112340355 0.331972014240493 no 2291 0.339379524251716 3159 5487158 An arginine aminopeptidase inhibitor. SGTC_2551 apiole 73.87 µM -0.415326548691547 0.331557267653116 no 2292 0.338951434365858 3156 10659 A possible DNA adduct former. SGTC_2366 9070441 60.58 µM -0.416127845266239 0.331273202871068 no 2293 0.338658227605296 3139 6837235 SGTC_528 3492-0019 172 µM -0.416231734513074 0.331236380570192 no 2294 0.338620220084528 3213 2869262 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.416400572986017 0.331176541273966 no 2295 0.338558454620587 3166 6708561 SGTC_3168 9103419 49.47 µM -0.418037602815351 0.330596573121743 no 2296 0.337959812301271 3206 16649256 SGTC_42 0133-0086 60.653 µM -0.418156155024085 0.330554588126602 no 2297 0.337916475057014 3067 162923 Model of phenazepam hydroxylation. SGTC_1044 1222-0021 1.78 µM -0.418346459626378 0.330487196643226 no 2298 0.337846912924519 3196 4306703 SGTC_2868 9035608 32.47 µM -0.418437343961202 0.330455014231213 no 2299 0.337813693883807 3090 6462614 SGTC_1223 0764-0573 147 µM -0.420045185220347 0.329885880359425 no 2300 0.337226222530516 3150 1609797 SGTC_2729 fluphenazine 10.66 µM -0.420113662138908 0.329861650045207 no 2301 0.33720121130265 3123 3372 An atypical antipsychotic. SGTC_1525 8-methoxypsoralen 92.5 µM -0.420189552578728 0.329834797316862 no 2302 0.337173493123113 3355 4114 Related to psoralen; DNA damaging agent. SGTC_1507 4075-3230 155 µM -0.422030497348684 0.329183674727118 no 2303 0.336501378628551 3219 659771 SGTC_2933 9026794 32.47 µM -0.423526575408376 0.328654909089968 no 2304 0.335955556647307 3158 17586027 SGTC_1813 st051246 8.6015 µM -0.424423156325185 0.328338190677123 no 2305 0.335628617963042 3218 5291959 SGTC_1240 0356-0016 42.1 µM -0.42676307131969 0.327512193976722 no 2306 0.334775953242326 3172 4305613 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.427118837544984 0.327386681262592 no 2307 0.334646386514939 3311 551469 SGTC_2069 5228469 200 µM -0.427165356630725 0.327370270981748 no 2308 0.334629446154684 3236 2835210 SGTC_431 k089-0097 107 µM -0.429840574893852 0.326427111102797 no 2309 0.333655807662124 3220 5499420 SGTC_2586 curcumin 80 µM -0.43041378479396 0.326225167467057 no 2310 0.333447334830733 3248 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_329 k048-0121 21.3 µM -0.431688274563063 0.325776343358345 no 2311 0.332983995300023 3224 6832902 SGTC_2955 9076254 12.21 µM -0.432389737476915 0.325529423934965 no 2312 0.332729087826603 3252 16459619 SGTC_2814 7977482 42.97 µM -0.432421298587989 0.325518316021148 no 2313 0.33271762052208 3295 6456762 SGTC_721 1187-1332 279 µM -0.433626693849859 0.325094193948449 no 2314 0.332279773608353 3124 25730 SGTC_1893 st059353 36.1 µM -0.43515038812796 0.324558401553613 no 2315 0.331726635454064 3223 3112488 SGTC_245 methotrexate 289.6 µM -0.435378227128797 0.324478315330138 no 2316 0.331643955829073 3243 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2457 5731572 11.68 µM -0.436173017282217 0.324199007311115 no 2317 0.331355601690988 3290 2865357 SGTC_1903 st060211 78.3 µM -0.436337349550488 0.324141269407681 no 2318 0.331295993525019 3305 688960 SGTC_2686 alizarin 95.37 µM -0.43806634312269 0.323534046595382 no 2319 0.33066909580155 3190 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.43913746544183 0.32315810373048 no 2320 0.33028096675167 3194 65057 A dermal irritant. YDR527W RBA50 SGTC_1287 0971-0001 34.6 µM -0.439707516005763 0.322958100781189 no 2321 0.330074479131729 3223 4665869 SGTC_1262 0737-0114 49.6 µM -0.440243299636299 0.322770167087003 no 2322 0.329880451092136 3340 765919 SGTC_1959 st077091 55.8 µM -0.440629551796986 0.322634711742559 no 2323 0.329740602582678 3124 821356 YKL052C ASK1 SGTC_2761 levamisole 97.89 µM -0.440759344602366 0.322589199792833 no 2324 0.329693614451479 3320 26879 An alkaline phosphatase inhibitor. SGTC_1149 3909-7961 23.3 µM -0.442447597000294 0.321997455108535 no 2325 0.329082671401278 3213 735261 SGTC_108 0509-0257 621.132 µM -0.445417297788284 0.32095764862217 no 2326 0.328009106959883 3220 536624 SGTC_357 1325-0123 420 µM -0.445480235374091 0.320935626902585 no 2327 0.327986369979319 3277 1098503 SGTC_1711 st032263 62.8 µM -0.445973748023597 0.320762969777826 no 2328 0.327808104539601 3220 3958979 SGTC_3326 9140064 16.379 µM -0.446555333987341 0.320559549654789 no 2329 0.327598075831358 3146 1868434 SGTC_176 1486-1328 72.834 µM -0.448915840701821 0.319734473799203 no 2330 0.326746184232301 3256 22310231 SGTC_334 1502-1024 68.5 µM -0.449325605351424 0.319591338053693 no 2331 0.326598394620754 3286 3296216 SGTC_3353 9151644 39.2805 µM -0.450619644113062 0.319139491168863 no 2332 0.326131853035618 3313 4909158 SGTC_3017 9080681 49.47 µM -0.450703893548364 0.319110082618307 no 2333 0.326101487893242 3260 16451914 SGTC_1290 0986-0249 10.2 µM -0.450813231650634 0.319071918183258 no 2334 0.32606208202432 3232 53329 SGTC_2318 6029776 164 µM -0.451429862466039 0.318856719278621 no 2335 0.32583988230376 3348 818325 SGTC_1931 st074438 57.1 µM -0.45227832521948 0.318560712816694 no 2336 0.325534244250727 3254 2787313 SGTC_1140 3229-1848 2.98 µM -0.452332451255193 0.318541833584573 no 2337 0.325514750640986 3296 2849525 SGTC_145 3737-0113 38.366 µM -0.456129089531596 0.317218739042087 no 2338 0.324148576541853 3328 6849351 SGTC_1977 st070720 65.3 µM -0.456275314188268 0.317167827603217 no 2339 0.324096006551834 3298 682188 SGTC_1804 st050076 49.1 µM -0.456617029437916 0.317048865162115 no 2340 0.323973168394374 3292 3895976 SGTC_1358 1509-0022 2.48 µM -0.457093406849951 0.316883053897252 no 2341 0.323801954514126 3277 3258434 SGTC_938 3126-1755 342 µM -0.45748919849545 0.316745319845729 no 2342 0.323659732158305 3344 1777771 SGTC_3094 9117742 49.47 µM -0.457602770811752 0.316705801782279 no 2343 0.323618926241754 3177 17149698 SGTC_1750 st081859 2.357 µM -0.457660870148194 0.316685586632209 no 2344 0.323598052285536 3296 5291695 SGTC_2645 abamectin 100 µM -0.461414554441059 0.315380687917517 no 2345 0.322250605697845 3283 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_994 3910-0338 138 µM -0.463569734987413 0.314632517289969 no 2346 0.321478021032487 3371 3479481 SGTC_1167 k781-0610 148 µM -0.465487922960113 0.31396725801958 no 2347 0.320791041784349 3227 4525169 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.467045714602552 0.313427434564045 no 2348 0.320233585828076 3300 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1487 3970-0795 2.82 µM -0.467486835254842 0.313274644996212 no 2349 0.320075804353942 3307 3765103 SGTC_524 r073-0010 27.8 µM -0.469935008912874 0.312427261852219 no 2350 0.319200725599361 3170 2772106 SGTC_549 1661-1316 519 µM -0.471312450204172 0.311950925191617 no 2351 0.318708813038826 3385 2857282 SGTC_2828 7998861 71.43 µM -0.471622951693569 0.311843593224967 no 2352 0.31859797065072 3310 2988188 SGTC_1173 0443-0020 122 µM -0.471629594402413 0.311841297194724 no 2353 0.318595599523091 3226 5331295 SGTC_599 1935-0052 86.5 µM -0.473555475837988 0.311175931371228 no 2354 0.317908466072092 3207 9557311 SGTC_2792 7535235 81.82 µM -0.475651644002845 0.310452434494474 no 2355 0.317161288157472 3247 1281891 SGTC_3274 9138298 49.47 µM -0.475787576582471 0.310405542346431 no 2356 0.317112860750308 3274 17015756 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.475979375458856 0.310339383454606 no 2357 0.317044535716379 3218 688803 SGTC_1797 st048695 56.8 µM -0.477468038937469 0.309826094309205 no 2358 0.316514437315621 3328 592262 YIL048W NEO1 SGTC_921 1561-0023 372 µM -0.480972264547239 0.308619306046223 no 2359 0.315268105545496 3257 24050882 SGTC_1986 st071812 45 µM -0.4814385045479 0.308458897221404 no 2360 0.315102438061134 3326 11838594 SGTC_2491 paeonol 100 µM -0.481892457548488 0.308302750833819 no 2361 0.314941172200376 3316 11092 Increases levels of cortical cytochrome oxidase. SGTC_1596 piperlongumine 63 µM -0.482556729903962 0.308074323320917 no 2362 0.314705254406674 3377 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1936 st074407 74.3 µM -0.482873295031145 0.307965490224904 no 2363 0.314592852200464 3238 809813 SGTC_2740 felodipine 17.08 µM -0.484016449889976 0.307572621443269 no 2364 0.314187097377901 3298 3333 L-type calcium channel blocker SGTC_1331 1472-0049 76.2 µM -0.485920812621288 0.306918637840972 no 2365 0.313511655728769 3224 24051409 SGTC_1684 st024538 14.6195 µM -0.486502746211595 0.306718916442866 no 2366 0.313305379364456 3261 6732859 SGTC_2421 5690543 90.72 µM -0.486881371973519 0.306589001719211 no 2367 0.313171200306182 3328 3397993 SGTC_271 rotenone 740 µM -0.487047312976286 0.306532071414046 no 2368 0.313112401200184 3373 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2338 7999974 200 µM -0.488211365926013 0.306132844576992 no 2369 0.312700067343021 3274 315925 SGTC_2799 7812892 81.82 µM -0.488217787094717 0.30613064299293 no 2370 0.312697793469276 3376 20205235 SGTC_174 3553-0389 74.3 µM -0.488257330007709 0.306117085327645 no 2371 0.312683790631645 3371 738071 SGTC_1275 0867-0008 21.1 µM -0.488405862399117 0.306066161951294 no 2372 0.31263119512713 3214 3422836 SGTC_2384 9036245 200 µM -0.488414347195051 0.306063253106653 no 2373 0.31262819076553 3273 6462766 SGTC_2524 avocatin b 10.57 µM -0.489429426314316 0.305715341576244 no 2374 0.312268853657702 3300 6710748 SGTC_2721 ifenprodil 61.44 µM -0.492117398065615 0.304794904679748 no 2375 0.311318176850475 3387 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1276 0871-0068 94.2 µM -0.493092721283229 0.304461231482423 no 2376 0.310973536818868 3311 3414906 SGTC_988 1497-1057 103 µM -0.494588431151863 0.303949842027316 no 2377 0.310445335054287 3408 3533044 SGTC_2283 7944793 200 µM -0.499209476621444 0.302372312651254 no 2378 0.308815909579625 3329 2970533 SGTC_2794 7785382 27.27 µM -0.499338165436599 0.302328433551047 no 2379 0.308770586268405 3380 2205081 SGTC_1159 4092-0538 61.2 µM -0.499963261949846 0.302115334678318 no 2380 0.308550473038411 3339 717301 SGTC_2197 6588183 93.1375 µM -0.499997349027513 0.302103716143394 no 2381 0.3085384720421 3294 884136 SGTC_1157 4092-0394 27.6 µM -0.500217138438556 0.302028806033488 no 2382 0.308461095961005 3462 3659885 SGTC_1785 bathophenanthroline 24 µM -0.501022802799119 0.301754285433441 no 2383 0.3081775374475 3252 72812 An iron chelator. SGTC_699 0375-0592 111 µM -0.501618164645317 0.301551495030081 no 2384 0.307968069714667 3404 762578 SGTC_2068 5226020 147 µM -0.501841217971475 0.301475535053009 no 2385 0.307889608376401 3306 1810509 SGTC_1160 4092-0570 10.5 µM -0.503629099136522 0.300866990187586 no 2386 0.307261020059386 3288 4994975 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.503740605963336 0.300829054735981 no 2387 0.307221834900819 3337 91467 include heat shock SGTC_2325 6158266 200 µM -0.504206779944383 0.300670482252852 no 2388 0.307058038265013 3324 3623240 SGTC_681 1642-0006 26.6 µM -0.504327052929961 0.300629576642007 no 2389 0.307015784944455 3383 4446530 SGTC_2026 5148700 152 µM -0.504979094583858 0.300407856851801 no 2390 0.306786759630806 3277 79838 SGTC_1773 st048542 73.5835 µM -0.505465599019233 0.300242474363385 no 2391 0.306615927280489 3256 3237138 SGTC_1230 0170-0365 3.77 µM -0.505939581289567 0.300081388259975 no 2392 0.306449532390016 3448 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_624 k048-0052 28 µM -0.506902992701811 0.299754086876689 no 2393 0.30611144286815 3302 6835531 SGTC_1699 st031318 29.054 µM -0.508992726268129 0.299044694457021 no 2394 0.305378661289742 3377 5340658 SGTC_440 fluspirilene 35.1 µM -0.509952757907174 0.29871905258758 no 2395 0.305042279618315 3458 3396 An atypical antipsychotic. SGTC_2575 plumbagin 510 nM -0.510129658921017 0.298659065515292 no 2396 0.304980313932266 3258 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3298 9116858 71.43 µM -0.512232308015969 0.2979464778015 no 2397 0.304244217130444 3401 2506942 SGTC_600 1495-0418 41.6 µM -0.513327811375224 0.297575519111167 no 2398 0.303861016396816 3316 5377768 SGTC_2302 7771753 200 µM -0.515116318593676 0.296970349375757 no 2399 0.303235870037376 3353 2203047 SGTC_2762 leflunomide 42.06 µM -0.516214917886642 0.296598900265359 no 2400 0.302852156149088 3350 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_411 enrofloxacin 100 µM -0.517436866354294 0.296185995568237 no 2401 0.302425614980797 3461 71188 A bacterial gyrase inhibitor. SGTC_2086 5274770 176.623 µM -0.518252989577372 0.295910368941779 no 2402 0.302140883912715 3355 689278 SGTC_1733 st037357 54.9 µM -0.520462710599714 0.295164678935676 no 2403 0.301370555770873 3260 1272339 YGL099W LSG1 SGTC_3332 9141069 11.198 µM -0.521690268783689 0.294750802690062 no 2404 0.300943000603758 3272 17332883 SGTC_1221 2958-7315 257 µM -0.522056277105248 0.294627453299895 no 2405 0.30081557385552 3397 4562705 SGTC_1186 1319-0216 26 µM -0.522402042093121 0.294510948045127 no 2406 0.300695217239717 3459 4565136 SGTC_804 1595-0054 20.9 µM -0.52297945744779 0.294316435785891 no 2407 0.300494274396321 3300 761523 Stimulates phospholipase C. SGTC_1345 1488-0192 31.4 µM -0.523477409478829 0.294148739767465 no 2408 0.300321033825438 3419 658348 SGTC_1210 3013-0140 750 nM -0.523704897720818 0.294072142922372 no 2409 0.300241904292222 3419 905973 SGTC_132 0417-1715 25.805 µM -0.523732103725894 0.294062983091859 no 2410 0.300232441583687 3459 6769098 SGTC_1901 st060216 58.6 µM -0.525360001804174 0.29351513582204 no 2411 0.299666476693309 3338 688792 SGTC_3134 9127454 49.47 µM -0.52678759822417 0.293035086770468 no 2412 0.299170548042227 3463 24262820 SGTC_2943 9068529 45.32 µM -0.527568169644058 0.292772762940558 no 2413 0.298899545167443 3422 3270634 SGTC_2268 7933382 153.85 µM -0.528941022338622 0.29231165799961 no 2414 0.298423181741012 3416 935025 YOR257W CDC31 SGTC_774 k060-0086 136 µM -0.529152656826932 0.292240605624971 no 2415 0.298349777856176 3455 5911235 SGTC_3268 9137683 49.47 µM -0.530338962143662 0.291842474323505 no 2416 0.297938468717615 3319 1953228 SGTC_206 4546-0025 72.014 µM -0.530763764321985 0.291699969584608 no 2417 0.297791246565532 3423 6620745 YIL048W NEO1 SGTC_1575 cyproterone acetate 48 µM -0.531034618246662 0.291609125479058 no 2418 0.297697395028431 3337 9880 An androgen receptor antagonist and liver toxin. SGTC_2598 perillyl alcohol 100 µM -0.531243846930964 0.291538959441941 no 2419 0.297624906025957 3432 10819 An apoptosis inducer. SGTC_2490 carminic acid 95.39 µM -0.532484622741657 0.29112302004655 no 2420 0.297195194653965 3399 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2783 7738165 71.43 µM -0.532620757600207 0.291077401079441 no 2421 0.297148065052551 3327 17201110 SGTC_981 1488-1094 54.9 µM -0.533259260377261 0.290863482541854 no 2422 0.29692706234499 3382 3449522 SGTC_351 caspofungin 25 nM -0.533793188435313 0.290684656266258 no 2423 0.296742313473894 3369 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_307 1501-1223 22.3 µM -0.53406111771784 0.290594939221157 no 2424 0.29664962487861 3403 2830329 SGTC_3316 9136639 10.545 µM -0.534524484629611 0.290439809795887 no 2425 0.296489357062277 3424 4903665 SGTC_513 4245-1575 41.7 µM -0.535033853886863 0.290269324106683 no 2426 0.296313223904199 3347 719745 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.535886172786926 0.289984158191702 no 2427 0.296018610652533 3362 688761 SGTC_420 mitomycin C 81.9 mM -0.536816013623293 0.289673205151713 no 2428 0.295697354553498 3343 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1839 st053978 48 µM -0.537975720545127 0.289285600827999 no 2429 0.295296905373708 3451 3788398 SGTC_1819 st053448 58.6 µM -0.538042155952648 0.289263403764507 no 2430 0.29527397265127 3320 2857616 SGTC_691 1548-0686 185 µM -0.538811555630788 0.289006394161692 no 2431 0.29500844465519 3355 46495133 SGTC_880 0833-0487 87.2 µM -0.539672149774429 0.288719049380748 no 2432 0.294711574880834 3411 76075 SGTC_2612 dictamnine 15.46 µM -0.539989454420493 0.288613138118723 no 2433 0.294602152531701 3364 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_867 0518-0118 155 µM -0.540797567600043 0.288343485438796 no 2434 0.294323559793252 3436 6848158 SGTC_1503 4585-0012 61.3 µM -0.541035378090501 0.288264155028535 no 2435 0.294241599061808 3467 2922052 SGTC_1754 st042065 16.137 µM -0.542339022425416 0.287829459637138 no 2436 0.293792489055213 3413 1126236 YIL048W NEO1 SGTC_627 1391-0720 175 µM -0.545426750157574 0.286801105216775 no 2437 0.292730023344856 3381 997839 SGTC_1615 st002656 86.5 µM -0.54671304357231 0.286373225169978 no 2438 0.292287945806953 3472 1584458 SGTC_894 0960-0238 55.9 µM -0.547364570271725 0.286156613246902 no 2439 0.292064145514321 3456 6741907 YDL195W SEC31 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.547906277094283 0.285976572219866 no 2440 0.291878129249177 3407 2333 A French combination drug. SGTC_1658 st012944 20 µM -0.554481726394822 0.283795468545196 no 2441 0.289624604131331 3431 24207260 SGTC_2045 5106652 78.05 µM -0.554921947303562 0.283649730375755 no 2442 0.289474024649458 3439 673349 SGTC_2434 5670830 169.91 µM -0.555081039273815 0.283597070701676 no 2443 0.28941961559395 3426 1549830 SGTC_2469 5655019 90.81 µM -0.557078697865456 0.282936241766223 no 2444 0.288736830601419 3482 2788239 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.558037424021473 0.282619356266225 no 2445 0.288409414636249 3455 66535 A nucleotide analog. SGTC_543 3844-1095 191 µM -0.558652122043566 0.282416271366678 no 2446 0.288199580343013 3432 4230703 SGTC_69 0096-0274 206.684 µM -0.559029307538069 0.282291690988203 no 2447 0.288070859367044 3603 6741392 SGTC_3088 9117578 49.47 µM -0.559053482347335 0.282283707206256 no 2448 0.288062610226836 3490 678341 SGTC_2479 5617353 43.85 µM -0.559647674200347 0.282087508251135 no 2449 0.287859889931373 3491 2731746 SGTC_2521 angolensin 13.4 µM -0.559902363977984 0.282003431164358 no 2450 0.287773018113431 3485 821428 A flavenoid. SGTC_322 k048-0136 19.3 µM -0.560084074893742 0.281943452921794 no 2451 0.287711046135609 3457 6823282 SGTC_1953 st076800 12.1 µM -0.560437445586627 0.281826831665103 no 2452 0.287590548150595 3381 297591 SGTC_2379 9035213 200 µM -0.561456882580739 0.281490522029691 no 2453 0.287243057985053 3473 646551 SGTC_1569 carminic acid 40.6 µM -0.561609825365396 0.281440083307171 no 2454 0.287190942323601 3478 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2738 aclarubicin 5.55 µM -0.562382225702098 0.281185421453467 no 2455 0.286927813254219 3360 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2275 7947463 200 µM -0.562417615027333 0.281173756192553 no 2456 0.28691576011841 3448 1225414 SGTC_3292 9120825 59.784 µM -0.562500123844775 0.281146560004049 no 2457 0.286887659638849 3514 24824900 SGTC_1296 1068-0102 11.9 µM -0.563730585704489 0.280741131479301 no 2458 0.28646874932626 3429 767053 SGTC_805 3852-0218 479 µM -0.563885398936325 0.280690141641337 no 2459 0.28641606377889 3365 6615355 SGTC_3125 9127534 49.47 µM -0.565537440461197 0.280146298498546 no 2460 0.28585413282446 3393 1639235 SGTC_1193 1488-0126 41.5 µM -0.567082760434196 0.279638050142626 no 2461 0.285328977484521 3458 1384710 SGTC_1368 1852-0141 284 µM -0.567365236436025 0.279545193540134 no 2462 0.285233031676717 3443 2838987 SGTC_1857 st056007 79.3 µM -0.568570653557672 0.279149112502111 no 2463 0.284823772525241 3475 619834 SGTC_1209 2323-2347 50.3 µM -0.56994926890207 0.278696455966404 no 2464 0.284356053443806 3469 5412760 SGTC_1657 st012939 43.4 µM -0.570255067743591 0.278596097983612 no 2465 0.284252355661625 3495 24207257 SGTC_1766 st045414 44.774 µM -0.570893178507872 0.278386737573937 no 2466 0.284036027630053 3489 253960 SGTC_1760 st045453 10.4495 µM -0.571588525853641 0.278158685511065 no 2467 0.283800385349101 3478 3323419 YIL048W NEO1 SGTC_1622 st003707 19.4 µM -0.578866666163823 0.275777167409817 no 2468 0.281339571879351 3488 10140899 SGTC_1067 clotrimazole 1.36 µM -0.578941368474745 0.275752775725223 no 2469 0.28131436775707 3444 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3276 9139060 49.47 µM -0.579389706998977 0.275606407195961 no 2470 0.281163123869597 3510 4870619 SGTC_3176 9106582 49.47 µM -0.579455565508848 0.275584909667233 no 2471 0.281140910267197 3410 17018027 SGTC_1015 4130-4525 82 µM -0.580049621570882 0.275391035214014 no 2472 0.280940577740856 3393 1363237 SGTC_466 geldanamycin 89.2 µM -0.580751009411962 0.275162218692737 no 2473 0.28070413875365 3402 5288382 HSP90 inhibitor. SGTC_620 0109-0052 432 µM -0.581039462979032 0.275068142522268 no 2474 0.280606928523562 3517 493037 SGTC_2653 dihydrofissinolide 100 µM -0.582357633023284 0.274638436612443 no 2475 0.280162906332015 3492 6857746 SGTC_1007 4101-0031 70 µM -0.583630334043022 0.274223867395317 no 2476 0.279734523553568 3507 1146276 SGTC_314 1671-0008 2.74 µM -0.585526786758462 0.273606691444136 no 2477 0.279096780318295 3436 3913060 SGTC_3335 9143315 29.6265 µM -0.586167381695773 0.273398373532014 no 2478 0.27888151950315 3423 4899691 SGTC_1431 4049-0260 9.09 µM -0.586655230023423 0.273239780663547 no 2479 0.27871764074022 3484 3854841 SGTC_1574 spiramycin 23.7 µM -0.58884003013516 0.272530091379579 no 2480 0.277984294962919 3485 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2675 theaflavin digallate 100 µM -0.589197305323224 0.272414124697068 no 2481 0.277864462300756 3499 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_139 0099-0334 718.624 µM -0.590260780974509 0.272069080040006 no 2482 0.277507914254321 3526 97690 SGTC_3023 9089636 49.47 µM -0.591250243210658 0.27174824429654 no 2483 0.277176381370272 3581 17249241 SGTC_1039 k821-0043 94 µM -0.59336219651447 0.271064068381381 no 2484 0.276469391348905 3506 15992768 SGTC_2679 rapamycin 1 nM -0.594042133899216 0.270843982851872 no 2485 0.276241966230006 3505 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1444 4112-3581 28 µM -0.595223005046122 0.270461964656244 no 2486 0.275847207334242 3532 2877249 SGTC_423 5-fluorouracil 457 µM -0.596480553688171 0.270055437137547 no 2487 0.275427120543066 3463 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_49 0717-0965 32.132 µM -0.59682953533756 0.269942676120835 no 2488 0.27531059829996 3633 5889349 YGL099W LSG1 SGTC_1266 0828-0227 32.9 µM -0.597944863277978 0.269582455615434 no 2489 0.274938361780167 3443 3913820 SGTC_328 k915-0120 63.5 µM -0.597954223045431 0.269579433685226 no 2490 0.27493523904247 3508 6624543 SGTC_3182 9108849 49.47 µM -0.598094512997655 0.269534141170256 no 2491 0.274888435623177 3543 17133045 SGTC_606 k015-0008 38.6 µM -0.598377667675772 0.269442736493902 no 2492 0.274793981753016 3562 1970475 SGTC_2131 toluylene red 5.2905 µM -0.600830544073266 0.268651578547439 no 2493 0.273976429009274 3456 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1410 3909-8106 77.9 µM -0.602445983669445 0.2681311682295 no 2494 0.273438654420959 3531 1039210 SGTC_2857 9024691 58.44 µM -0.604855803470219 0.267355794177995 no 2495 0.272637405737943 3515 16478292 SGTC_3093 9117344 49.47 µM -0.605552933134991 0.26713169963686 no 2496 0.2724058323772 3530 24824913 SGTC_2037 5169046 200 µM -0.606792450146171 0.266733487287997 no 2497 0.27199432957251 3519 5718022 SGTC_605 1315-0399 119 µM -0.608875452372562 0.26606496984281 no 2498 0.271303498167699 3596 24020461 SGTC_3116 9124943 49.47 µM -0.609064304556907 0.266004401721748 no 2499 0.271240908267584 3463 41905195 YPL160W CDC60 SGTC_1299 1079-1439 3.74 µM -0.60931929570651 0.265922632788104 no 2500 0.271156409835622 3449 323161 SGTC_2683 piperine 63.03 µM -0.609632558188753 0.265822195212349 no 2501 0.271052619542413 3472 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1457 k015-0032 57.3 µM -0.609922055411035 0.26572939430267 no 2502 0.270956720788831 3541 4302660 SGTC_607 4491-0986 66.8 µM -0.610353809825094 0.265591022105822 no 2503 0.270813729422358 3568 698981 YDR232W HEM1 SGTC_2040 5100729 123 µM -0.611301114043288 0.265287550386264 no 2504 0.270500126804889 3506 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2755 lomerizine 42.69 µM -0.611539793076132 0.265211116622061 no 2505 0.270421141353938 3520 3949 A calcium channel blocker. SGTC_2322 7413319 38.22 µM -0.612873457234182 0.264784234438195 no 2506 0.269980007486478 3552 1840400 SGTC_688 0527-0193 473 µM -0.613476827131791 0.264591221301001 no 2507 0.269780550218585 3499 4007154 SGTC_622 1348-1566 26.3 µM -0.614856202121483 0.264150239437609 no 2508 0.269324844643132 3531 7340407 SGTC_671 0560-0003 407 µM -0.616323477438104 0.263681567389305 no 2509 0.268840523396418 3460 3238678 SGTC_445 e6 berbamine 66 µM -0.61647027783287 0.263634700263689 no 2510 0.268792091301302 3553 6610268 A calcium/calmodulin antagonist. SGTC_24 0417-1663 219 µM -0.617337599092959 0.263357888209623 no 2511 0.268506035854181 3546 4329390 SGTC_3319 9138450 16.7555 µM -0.618290374733891 0.263053973900151 no 2512 0.268191972781503 3463 2029690 SGTC_1590 st077108 57.8 µM -0.618365320992154 0.263030075311253 no 2513 0.268167276119248 3535 5489485 SGTC_824 1304-0008 100 µM -0.618431237258939 0.263009057090255 no 2514 0.26814555601049 3540 768245 SGTC_658 3253-0951 102 µM -0.618979679645302 0.262834212709614 no 2515 0.267964872765126 3540 1184878 SGTC_1563 conessine 56.1 µM -0.619558438787755 0.262649767776482 no 2516 0.267774268231596 3598 441082 An anti-amoebic, histamine inhibitor. SGTC_2184 6075246 200 µM -0.620508126187085 0.262347255164124 no 2517 0.267461652830325 3537 2267320 SGTC_3123 9126162 49.47 µM -0.621490654923975 0.262034469209071 no 2518 0.26713842064254 3577 25239884 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.621806596599178 0.261933930475214 no 2519 0.267034524104057 3542 4330530 SGTC_1706 st031321 9.9705 µM -0.624860761926593 0.260963056998233 no 2520 0.266031223537806 3566 6103185 SGTC_2258 7960471 200 µM -0.626840201942048 0.260334812402252 no 2521 0.265381994075024 3508 2974708 SGTC_3214 9129694 49.47 µM -0.627944963801836 0.259984516643472 no 2522 0.265019997124197 3535 17158655 SGTC_1364 1653-0028 37.6 µM -0.628080939074871 0.259941418672536 no 2523 0.264975459497038 3527 5718652 SGTC_379 3970-0972 5.9 µM -0.628155100391576 0.259917914464551 no 2524 0.264951170146148 3541 2898042 YBL034C STU1 SGTC_344 k064-0035 6.43 µM -0.629630097543376 0.259450666235449 no 2525 0.264468313505536 3506 5088750 SGTC_1452 4194-0072 190 µM -0.629779704737006 0.25940329805324 no 2526 0.264419362961398 3599 1343545 SGTC_1001 4048-4355 44.4 µM -0.630609425382981 0.259140675500497 no 2527 0.264147967254855 3562 21824233 SGTC_266 formosanin C 406 nM -0.630764736810283 0.259091531722114 no 2528 0.264097181765121 3524 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2917 7979103 53.79 µM -0.630887678225662 0.259052633908596 no 2529 0.264056984516197 3584 2980565 SGTC_920 mycophenolic acid 780.421 nM -0.630952571805791 0.259032103246424 no 2530 0.26403576799746 3534 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2389 9091542 195.52 µM -0.631148587598835 0.258970093993404 no 2531 0.263971687229858 3531 3626624 YOL127W RPL25 SGTC_106 0092-0003 11.579 µM -0.631325827062319 0.258914031210136 no 2532 0.26391375157595 3513 1072148 SGTC_2537 larixol 68.93 µM -0.631496218142203 0.258860140565564 no 2533 0.263858060618426 3583 6708759 SGTC_221 trifluoperazine 10.304 µM -0.635721225147096 0.257525729860785 no 2534 0.262479069808739 3592 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2803 7707263 71.43 µM -0.635765175616921 0.257511867506664 no 2535 0.262464744324405 3538 2199229 SGTC_2329 6138490 200 µM -0.636908124543002 0.257151507788022 no 2536 0.262092345180333 3565 720019 SGTC_1850 st056238 17 µM -0.637087488511747 0.257094980037041 no 2537 0.262033928851762 3591 5393177 SGTC_1307 1187-1599 12.2 µM -0.637721703679903 0.256895154732245 no 2538 0.26182742740343 3523 1538471 SGTC_1426 4048-4480 71.7 µM -0.637872391340236 0.256847688712084 no 2539 0.261778375541296 3580 14224343 SGTC_2969 9091408 28.7 µM -0.637922782401938 0.256831816744331 no 2540 0.261761973289776 3485 4286311 SGTC_3215 9129942 49.47 µM -0.638566308807752 0.256629166358646 no 2541 0.261552552313335 3530 17682944 SGTC_1713 st033146 12.748 µM -0.640487057560802 0.256024806411822 no 2542 0.260928000339236 3600 674619 SGTC_2883 9059145 45.46 µM -0.641204643122554 0.255799210133457 no 2543 0.260694866677979 3569 16476510 SGTC_2988 9073640 71.4286 µM -0.641278643055122 0.255775951759801 no 2544 0.260670831218308 3622 9102229 SGTC_1183 1254-0324 198 µM -0.643744361489125 0.255001601659118 no 2545 0.259870609129028 3605 5799357 SGTC_1950 st077106 7.18 µM -0.644476289512734 0.254771978574791 no 2546 0.259633314013725 3545 13831864 SGTC_1397 3532-0190 20.1 µM -0.644779079016259 0.254677018029948 no 2547 0.259535180700316 3513 5322280 SGTC_485 niflumic acid 177 µM -0.644834481074934 0.254659644897274 no 2548 0.259517227106128 3600 4488 A COX2 inhibitor. SGTC_706 4262-0057 46.9 µM -0.645496601689779 0.254452063304266 no 2549 0.259302709909647 3558 883298 SGTC_3259 9138485 49.47 µM -0.64781963241431 0.253724471238628 no 2550 0.258550807955966 3721 17646153 SGTC_1471 k673-0312 37 µM -0.648030361316 0.253658523325199 no 2551 0.258482656634657 3585 24099884 SGTC_1286 0929-0070 131 µM -0.64847083178505 0.253520706537422 no 2552 0.258340235209153 3645 1420408 SGTC_259 usnic acid 108.925 µM -0.649919608596624 0.253067683052319 no 2553 0.257872075685466 3660 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1508 1080-0625 72.9 µM -0.650635851488898 0.252843875777342 no 2554 0.257640790796592 3539 767111 SGTC_1816 st051957 91.6 µM -0.652634910422346 0.252219773505541 no 2555 0.256995836889955 3607 674121 SGTC_1158 4092-0494 91.8 µM -0.653520022089014 0.251943703077517 no 2556 0.25671054290531 3653 1148199 SGTC_155 k072-0202 43.6 µM -0.653964624697202 0.251805089660821 no 2557 0.256567298425819 3562 5857737 SGTC_2849 9019321 12.99 µM -0.654758795687744 0.251557591804086 no 2558 0.256311531746682 3569 16489627 SGTC_1605 st000082 49.1 µM -0.654875825161923 0.251521131251794 no 2559 0.256273853066179 3603 1114022 SGTC_968 1309-0633 340 µM -0.656786022127594 0.250926404026056 no 2560 0.255659256588218 3580 3761976 SGTC_2765 myclobutanil 7.74 µM -0.657602029647947 0.250672572533917 no 2561 0.255396945009681 3619 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1100 amiodarone 5.07 µM -0.658507070165906 0.250391205121072 no 2562 0.255106177716915 3640 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1728 st035614 33.7865 µM -0.659724460749455 0.250012995608883 no 2563 0.254715333281715 3579 15945546 SGTC_2316 5844804 197.44 µM -0.659810222267519 0.249986363316298 no 2564 0.254687811289757 3655 776813 SGTC_1834 st055981 52.8 µM -0.659885672473124 0.249962934332834 no 2565 0.254663599620441 3651 471719 YDL150W RPC53 SGTC_227 fluconazole 33.516 µM -0.660085351767387 0.249900935050312 no 2566 0.254599529149977 3586 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_352 k048-0007 5.11 µM -0.660160402388059 0.249877634371075 no 2567 0.254575450075403 3593 6811911 SGTC_743 1275-0778 158 µM -0.663831200985558 0.248739384567017 no 2568 0.253399176834067 3614 2849257 YMR203W TOM40 SGTC_857 0438-0306 1.35 µM -0.664586639961775 0.248505479324267 no 2569 0.253157458361071 3648 4686136 SGTC_871 0574-0004 149 µM -0.665382079660003 0.248259315459473 no 2570 0.252903071955203 3588 9551173 SGTC_1370 2001-0092 44.6 µM -0.667110793081381 0.247724781029512 no 2571 0.252350683255655 3699 790957 SGTC_1628 st004252 77.7 µM -0.667800556888086 0.247511671239525 no 2572 0.252130455525809 3607 692968 SGTC_2923 7992654 58.14 µM -0.669188608362622 0.247083115192983 no 2573 0.251687586025624 3644 2985126 SGTC_1492 4158-0558 28.5 µM -0.669885621777865 0.24686806453522 no 2574 0.25146535307939 3619 3967268 SGTC_3014 9081533 49.47 µM -0.670362540452726 0.246720977803891 no 2575 0.25131335402451 3635 21367265 SGTC_2244 6635614 200 µM -0.671077551412546 0.246500548853665 no 2576 0.251085563458641 3534 836499 SGTC_883 0850-0245 24.6 µM -0.674535297357268 0.245436059576214 no 2577 0.249985526401551 3667 6823229 YPR165W RHO1 SGTC_1764 st044502 93.5 µM -0.675211873841572 0.245228060497257 no 2578 0.249770581918117 3638 8407 SGTC_263 alizarin 107.927 µM -0.675383742928938 0.245175238094034 no 2579 0.249715995725507 3642 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2687 chenodiol 100 µM -0.676007699170944 0.244983522246006 no 2580 0.2495178784125 3642 5702181 A cholesterol synthesis inhibitor. SGTC_1102 cgs 12066b 26.1 µM -0.676026837975311 0.244977642961221 no 2581 0.249511802818821 3606 6438352 A 5-HT1B full agonist. SGTC_1133 3473-0247 50 µM -0.676318959388908 0.244887915065476 no 2582 0.249419078934957 3615 711311 SGTC_2294 7971431 200 µM -0.67746406755807 0.244536354716531 no 2583 0.249055780453596 3586 5741572 SGTC_1416 3966-0321 25.3 µM -0.678052202725659 0.244355896714288 no 2584 0.248869297429288 3648 582530 YLR208W SEC13 SGTC_3165 9101544 49.47 µM -0.678168039509036 0.244320362879527 no 2585 0.248832577231256 3627 5002184 SGTC_1205 4161-2785 76 µM -0.679627029686098 0.243873044835303 no 2586 0.248370325181949 3615 3498106 SGTC_1716 st033144 30.6155 µM -0.679820333168027 0.243813812267617 no 2587 0.248309115172848 3657 674617 SGTC_2057 5236571 38.335 µM -0.680107991546721 0.243725681598211 no 2588 0.248218042351156 3640 54684039 YBR257W POP4 SGTC_363 0455-0021 3.06 µM -0.68024869482255 0.243682580222158 no 2589 0.24817350209454 3667 4597466 SGTC_1257 0669-0121 16 µM -0.680940426387555 0.243470743224524 no 2590 0.247954593351035 3675 4307855 SGTC_2716 st080858 38.6235 µM -0.681084561062405 0.243426615715404 no 2591 0.247908992765253 3626 5296050 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.681278127453931 0.243367361252448 no 2592 0.247847760270026 3674 4213774 SGTC_949 1165-0505 146 µM -0.683537266085763 0.242676371359318 no 2593 0.247133705188669 3678 6244267 SGTC_2440 5628896 157.78 µM -0.684624830065163 0.242344103477545 no 2594 0.246790347202871 3674 5522048 SGTC_2380 9035439 200 µM -0.684775556752384 0.242298073564446 no 2595 0.246742781000862 3718 6462575 SGTC_1572 epiandrosterone 68.9 µM -0.686384399806278 0.241807049749348 no 2596 0.24623536963053 3614 441302 A steroid. SGTC_2228 7354201 200 µM -0.68731346291885 0.241523742984565 no 2597 0.245942608391466 3678 753451 SGTC_567 1080-0542 68.4 µM -0.687485410973676 0.241471329242108 no 2598 0.245888445560506 3588 5950415 SGTC_615 k087-0205 167 µM -0.688297405038284 0.241223898171411 no 2599 0.245632757755581 3639 9642773 SGTC_2801 7907800 81.82 µM -0.688443586949848 0.241179368217627 no 2600 0.245586741886722 3693 6620925 SGTC_2944 9067346 25.62 µM -0.688834124192494 0.241060424627138 no 2601 0.245463829344554 3602 6473075 SGTC_2364 9055074 200 µM -0.689795732816511 0.240767689249326 no 2602 0.245161326269348 3650 6470630 SGTC_3147 9097027 49.47 µM -0.689813987879911 0.240762133867475 no 2603 0.245155585526705 3681 25236841 SGTC_1264 0783-0040 158 µM -0.689879020837973 0.240742343601155 no 2604 0.245135134940336 3604 2855798 SGTC_676 falcarinol 140 µM -0.690319157597906 0.240608428269185 no 2605 0.244996751472673 3690 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3112 9123419 49.47 µM -0.691810750383135 0.240154900286632 no 2606 0.244528092276163 3704 17015854 SGTC_468 gf-109203x 121 µM -0.692098648793142 0.240067416677694 no 2607 0.244437690086709 3582 2396 A protein kinase C inhibitor. SGTC_1726 st035556 14.5795 µM -0.692371640358563 0.239984478858045 no 2608 0.244351985391018 3731 5919439 SGTC_1192 1488-0095 21.4 µM -0.694056705800273 0.239472883614301 no 2609 0.243823323996836 3662 915875 SGTC_2798 7813637 45.45 µM -0.694074243734293 0.23946756213309 no 2610 0.243817825008049 3653 956368 SGTC_694 1315-0438 43.2 µM -0.694694765983888 0.239279320547353 no 2611 0.243623304421729 3617 6793154 SGTC_1509 1326-1131 80 µM -0.696752296689311 0.23865572701009 no 2612 0.242978912177328 3620 768313 SGTC_556 4058-0063 51.5 µM -0.700672786189672 0.23746997619259 no 2613 0.241753621565766 3736 6615692 SGTC_397 arbidol 50 µM -0.700875211459383 0.23740884065833 no 2614 0.241690447734877 3716 131410 A RNA synthesis inhibitor. SGTC_1971 st069429 63.5 µM -0.704110623975182 0.236432870224733 no 2615 0.24068194223446 3691 1246522 YGL099W LSG1 SGTC_3334 9142812 21.919 µM -0.705394840677581 0.236046096110838 no 2616 0.240282276926523 3723 45283678 SGTC_94 0334-0113 514.748 µM -0.705968628176647 0.235873398338727 no 2617 0.240103823576644 3649 6795178 SGTC_888 0916-0002 6.97 µM -0.70631044022529 0.235770553331568 no 2618 0.239997551138919 3728 2802138 YIL048W NEO1 SGTC_40 0327-0103 19.753 µM -0.70646912933326 0.235722815080578 no 2619 0.239948221988407 3620 409036 SGTC_2829 7992743 58.44 µM -0.708224204575584 0.235195193569222 no 2620 0.239403018685947 3700 16462845 SGTC_1142 3253-1408 9.78 µM -0.711104436115712 0.234330735719726 no 2621 0.238509760610656 3670 256655 SGTC_2486 5283202 22.39 µM -0.71187511892088 0.234099725529544 no 2622 0.238271055370814 3702 1377751 SGTC_644 1498-1197 63.3 µM -0.712425541363258 0.233934815049367 no 2623 0.238100651986589 3733 6741615 SGTC_1404 3909-7820 48.3 µM -0.712564942893405 0.233893059575644 no 2624 0.238057505749589 3658 23741373 SGTC_2333 9017922 200 µM -0.7135925500189 0.233585383937232 no 2625 0.237739582819509 3713 3163164 SGTC_2607 solasodine 47.35 µM -0.713938251403393 0.233481928030597 no 2626 0.237632681485975 3720 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3113 9123498 49.47 µM -0.714163072106012 0.233414660976207 no 2627 0.237563174275205 3726 8897275 SGTC_2746 daunorubicin 9.88 µM -0.715282767982068 0.233079804647031 no 2628 0.237217167137794 3591 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1741 st038134 10.228 µM -0.715910987735308 0.232892046074557 no 2629 0.237023156683878 3746 1272587 SGTC_2106 5357045 167.29 µM -0.716960466836574 0.232578571529447 no 2630 0.236699245098209 3734 668842 SGTC_1464 k208-0027 110 µM -0.720392052676912 0.231555212083963 no 2631 0.235641820904595 3721 X1464 SGTC_1553 gossypol 38.6 µM -0.721271978102063 0.231293207699295 no 2632 0.235371097077289 3614 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2154 5570129 200 µM -0.723007810735487 0.230776835731825 no 2633 0.234837542762263 3725 673366 SGTC_693 4161-2696 114 µM -0.723602197938266 0.230600166736411 no 2634 0.234654995819849 3733 805759 SGTC_650 1328-0195 38 µM -0.723704492490139 0.230569769473711 no 2635 0.234623587249405 3673 2780821 SGTC_254 nsc-64875 3.808 µM -0.724737011367693 0.230263077478735 no 2636 0.23430669233934 3726 56993 SGTC_842 0271-0008 11.1 µM -0.724799858335918 0.230244417235513 no 2637 0.23428741135158 3766 1221709 SGTC_1306 1185-0270 9.02 µM -0.727703669948527 0.229383153257636 no 2638 0.233397501657318 3722 1548076 SGTC_922 1866-0035 480 µM -0.729083808489374 0.228974441234261 no 2639 0.232975199160267 3714 3156169 SGTC_160 3453-0671 289.699 µM -0.729328252540092 0.228902094582492 no 2640 0.232900447068194 3731 5322268 SGTC_1161 k007-0610 110 µM -0.730447320888988 0.22857105442418 no 2641 0.23255840109978 3756 5843850 SGTC_848 0368-0089 85.6 µM -0.730463442976974 0.22856628719189 no 2642 0.232553475386017 3706 762535 SGTC_296 1222-0039 74.9 µM -0.731588407264615 0.22823377801365 no 2643 0.2322099130527 3687 5984176 SGTC_151 3013-0144 2.285 µM -0.732109772469162 0.228079768748432 no 2644 0.232050784770857 3701 906558 YHR107C CDC12 SGTC_285 1486-1325 46 µM -0.733319376215659 0.227722681665638 no 2645 0.231681829943464 3721 22310230 SGTC_748 act1.228 77.9 µM -0.733698014778736 0.227610968491326 no 2646 0.231566404356746 3673 4421505 YNR035C ARC35 SGTC_960 1222-0186 7.7 µM -0.735135254651607 0.227187207525577 no 2647 0.231128562700861 3751 3126296 SGTC_3137 9097352 49.47 µM -0.735502339723931 0.227079046179827 no 2648 0.231016807784886 3803 44120435 SGTC_1028 k015-0029 4.8 µM -0.735505975681477 0.227077974992843 no 2649 0.23101570100944 3720 4588309 SGTC_20 0481-0013 4.944 µM -0.735764152603468 0.227001920948538 no 2650 0.230937120233722 3734 182045 SGTC_2715 st079500 56.4 µM -0.736674236372257 0.226733942050933 no 2651 0.230660238974085 3685 28246688 SGTC_427 1354-0053 47.3 µM -0.737602769934436 0.226460714586879 no 2652 0.230377935853094 3811 6813657 SGTC_2023 5144124 124 µM -0.73883589052637 0.226098147837956 no 2653 0.230003327589233 3742 2830192 SGTC_2438 5259590 200 µM -0.740212888577522 0.225693665699885 no 2654 0.229585414139483 3767 1201127 SGTC_2222 6885208 172.143 µM -0.740235313911655 0.225687081827329 no 2655 0.229578611661776 3696 609514 SGTC_1924 st058459 75.1 µM -0.741716932396833 0.225252333036834 no 2656 0.229129429299064 3695 688683 SGTC_31 0508-1974 57.237 µM -0.742504490796405 0.225021434324479 no 2657 0.228890865964885 3695 6810525 SGTC_1757 st041620 31.8375 µM -0.742964217301537 0.224886712365403 no 2658 0.228751672324341 3800 5289815 SGTC_3138 9097216 49.47 µM -0.743142864269736 0.224834372557494 no 2659 0.228697595332948 3748 25237486 SGTC_2251 lansoprazole 556 µM -0.744286625455821 0.224499438264803 no 2660 0.228351545417726 3685 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_714 4296-0578 26.1 µM -0.744619750528808 0.22440194056164 no 2661 0.228250812341965 3778 1589775 SGTC_2121 5257820 149.641 µM -0.745044081323455 0.224277783945179 no 2662 0.228122535917817 3809 791256 SGTC_1664 st014217 9.02 µM -0.745603767506067 0.224114082824023 no 2663 0.227953403182402 3792 3982782 SGTC_2725 haloperidol 53.21 µM -0.745880635132384 0.224033127645455 no 2664 0.227869762062954 3711 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1708 st033234 31.827 µM -0.746515946198773 0.223847427599449 no 2665 0.227677901233593 3840 674664 SGTC_2108 5365811 200 µM -0.747759072712723 0.223484317603534 no 2666 0.227302746307539 3811 780283 SGTC_2437 5741531 144.16 µM -0.75216511907761 0.222200038995818 no 2667 0.225975883570201 3786 2262990 SGTC_2332 7982454 138.89 µM -0.755157480886726 0.221330229326688 no 2668 0.225077248624109 3733 2981748 SGTC_2195 6536160 144.242 µM -0.755917571749698 0.221109599194365 no 2669 0.22484930896012 3687 3834386 SGTC_2276 7947513 42.08 µM -0.757308368189137 0.220706221326697 no 2670 0.224432569313065 3658 2105100 SGTC_3295 9122362 53.5725 µM -0.758093863266207 0.220478587639743 no 2671 0.224197396608827 3796 4730473 SGTC_2308 7584454 197.62 µM -0.75820567663532 0.220446195464871 no 2672 0.224163931710983 3789 893577 SGTC_958 1222-0007 33 µM -0.758765568653162 0.220284036567916 no 2673 0.223996402926992 3827 7312461 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.759768718229085 0.219993670170944 no 2674 0.223696422251708 3704 756377 SGTC_3033 9090887 49.47 µM -0.760782874526083 0.219700341181701 no 2675 0.223393382461787 3809 19325384 SGTC_531 3788-1495 174 µM -0.761680734684552 0.219440836562464 no 2676 0.22312528814333 3738 2896655 SGTC_1136 pergolide 1.05886 µM -0.76218458975096 0.219295286697685 no 2677 0.222974921074312 3773 47811 A dopamine receptor agonist. SGTC_82 0054-0107 293.755 µM -0.762260421726988 0.219273385731078 no 2678 0.222952295294776 3762 3104697 SGTC_1477 0139-0234 16 µM -0.76262892837233 0.21916697554929 no 2679 0.222842363594306 3780 620880 SGTC_2492 derrusnin 100 µM -0.76266000157672 0.219158004191102 no 2680 0.222833095349416 3697 1715307 Part of coumarin class of compounds. SGTC_2259 7964009 200 µM -0.762750297219722 0.219131935514255 no 2681 0.222806163997594 3790 313134 SGTC_2568 diosmetin 100 µM -0.765373328189453 0.218375435551775 no 2682 0.222024635271014 3782 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1379 2144-0755 36.5 µM -0.76694233581424 0.217923643064694 no 2683 0.221557900513602 3837 5392327 SGTC_2307 7538926 6.34 µM -0.767904595540112 0.21764682922604 no 2684 0.221271933501279 3807 96582 SGTC_537 1334-0398 209 µM -0.768886702047571 0.217364515378721 no 2685 0.220980286177797 3754 5846986 SGTC_2188 6126565 140.678 µM -0.769485099137307 0.217192605385934 no 2686 0.220802693509231 3730 874518 SGTC_2948 9070189 9.45 µM -0.771336755484226 0.216661151676532 no 2687 0.220253675771343 3691 6473636 YDL196W YDL196W SGTC_1720 st037298 9.481 µM -0.771720419714586 0.216551128316414 no 2688 0.220140016962758 3812 597396 SGTC_2232 chlorophetanol 41.5365 µM -0.77265362372951 0.216283648450583 no 2689 0.219863699924355 3857 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3178 9107506 49.47 µM -0.772910519854507 0.216210049113483 no 2690 0.21978766922324 3808 8897194 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.775303724298359 0.215525106261764 no 2691 0.219080104595969 3823 94937 An inhibitor of serotonin biosynthesis. SGTC_1321 1326-2144 215 µM -0.776714209416671 0.215122010977043 no 2692 0.21866370079901 3806 3513030 SGTC_2759 disulfiram 3.38 µM -0.776807493621054 0.215095367203281 no 2693 0.218636177481613 3750 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1661 st013063 9.66 µM -0.780209087028152 0.214125115721139 no 2694 0.217633907239696 3840 721395 SGTC_814 3342-0569 96 µM -0.781244240613803 0.213830360516527 no 2695 0.217329429045063 3841 4346283 SGTC_845 0330-0138 4.51 µM -0.781600357862224 0.213729012424073 no 2696 0.217224738261596 3739 9039800 SGTC_2413 inermin 26.06 µM -0.782371985600261 0.213509509419207 no 2697 0.216997996331284 3874 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2024 5144227 134 µM -0.782777916773685 0.213394087952797 no 2698 0.216878768846075 3865 3475211 SGTC_3329 9141233 27.5565 µM -0.784504470184563 0.212903570547406 no 2699 0.216372079994062 3793 4909101 YNL103W MET4 SGTC_3339 9145883 14.936 µM -0.785472024370652 0.21262897434292 no 2700 0.216088433249352 3716 2030670 SGTC_1244 0416-0015 52.5 µM -0.785530610355664 0.212612354021968 no 2701 0.216071265187111 3809 96201 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.78564716382376 0.212579291099772 no 2702 0.216037112658137 3843 804 An inhibitor of viral and cellular DNA polymerases. SGTC_770 0389-1121 67.2 µM -0.78620081988965 0.212422275551783 no 2703 0.215874922919556 3945 6753108 SGTC_2393 9031399 185.94 µM -0.789350461972795 0.21153033460303 no 2704 0.214953600380047 3838 1526623 YDL150W RPC53 SGTC_1784 st039334 36.3 µM -0.791020349538368 0.21105833326972 no 2705 0.21446605834495 3857 3496984 SGTC_3236 9132701 49.47 µM -0.792559013806155 0.210623969769681 no 2706 0.214017398085687 3828 24282524 SGTC_2215 7188065 200 µM -0.794437760986869 0.210094313035905 no 2707 0.213470314276158 3819 940217 SGTC_2343 7990716 14.84 µM -0.794732984535784 0.210011154758464 no 2708 0.213384420500122 3818 6456862 SGTC_2003 4023581 200 µM -0.794848172834352 0.209978713878365 no 2709 0.213350912520679 3869 16641307 SGTC_2588 indole-3-carbinol 100 µM -0.79574407900696 0.209726497253802 no 2710 0.213090400454358 3861 3712 Induces cell cycle arrest. SGTC_226 1,3-diallylurea 8.28947 mM -0.795825133090492 0.20970368759715 no 2711 0.213066840662437 3791 74537 YKL182W FAS1 SGTC_493 zm226600 134 µM -0.796572203414442 0.209493521137236 no 2712 0.212849763121514 3822 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3187 9109394 49.47 µM -0.797138435690366 0.209334310774824 no 2713 0.212685318044309 3801 17098090 SGTC_2691 st077356 60.2 µM -0.797975854077236 0.209098980233765 no 2714 0.212442251180081 3884 2839272 SGTC_2241 6772625 37.8075 µM -0.799667314667871 0.208624122923402 no 2715 0.211951787538372 3757 2285411 SGTC_837 0091-0265 12.5 µM -0.80101877401 0.208245174168729 no 2716 0.211560388645282 3804 759367 SGTC_561 1550-0330 72.9 µM -0.80131259734912 0.208162839979826 no 2717 0.211475349903618 3775 6812934 SGTC_2353 9059630 146.67 µM -0.802772395115288 0.207754065256216 no 2718 0.211053150154569 3880 4779114 SGTC_1705 st027868 56.3335 µM -0.802901961746766 0.207717806741164 no 2719 0.211015701043373 3820 292948 SGTC_1800 st050079 29.0735 µM -0.805062553356884 0.207113728070562 no 2720 0.210391791734454 3756 3645560 SGTC_185 k048-0037 25.491 µM -0.805256641316782 0.207059514038084 no 2721 0.210335798440346 3850 6827589 SGTC_288 1315-0019 35.1 µM -0.805929176254213 0.206871721747612 no 2722 0.210141843560376 3912 6811474 SGTC_3107 9121808 49.47 µM -0.80635674793829 0.206752383114063 no 2723 0.210018589200958 3740 662681 SGTC_3162 9099653 49.47 µM -0.806527799756565 0.206704652617614 no 2724 0.209969292683573 3780 25237511 SGTC_2096 5468907 200 µM -0.806879325433512 0.206606582972237 no 2725 0.209868005599207 3883 759785 SGTC_2206 7254556 146.969 µM -0.80701694704178 0.206568196407032 no 2726 0.209828359729683 3848 4398905 SGTC_1097 itavastatin 7.23 µM -0.807380918699655 0.206466694762928 no 2727 0.209723528427957 3844 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_18 0111-0177 500 nM -0.808850671737237 0.206057121902476 no 2728 0.209300522780322 3899 721752 SGTC_1914 st062367 72.6 µM -0.809199144675227 0.205960084418164 no 2729 0.209200303419841 3861 978205 SGTC_1342 1486-1464 234 µM -0.81030156524341 0.205653277538741 no 2730 0.208883437984866 3867 3253938 SGTC_1712 st032288 53.4 µM -0.811651958969251 0.205277828904602 no 2731 0.208495683928176 3802 2883011 SGTC_1395 3486-0190 4.35 µM -0.811669710514027 0.205272896173255 no 2732 0.208490589551325 3822 6748079 SGTC_1434 4073-0095 163 µM -0.813489889127167 0.204767485773752 no 2733 0.20796862046282 3798 24133745 SGTC_2372 9071633 200 µM -0.813826000317849 0.204674238539241 no 2734 0.20787231896527 3912 21321366 SGTC_456 gingerol 170 µM -0.81392013937605 0.204648126095504 no 2735 0.207845351266406 3860 442793 A herb. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.815530590856645 0.20420172351097 no 2736 0.207384330742884 3761 17037758 SGTC_1245 0418-0076 17.2 µM -0.823285962164743 0.202060138459477 no 2737 0.205172697300146 3931 6790114 SGTC_3286 9117135 37.221 µM -0.825308550484795 0.20150383421277 no 2738 0.204598219332827 3843 3438150 SGTC_602 3130-1533 38.1 µM -0.828812752077378 0.200542193738964 no 2739 0.203605185606828 3905 720941 SGTC_29 0299-0004 12.984 µM -0.829431593324975 0.200372655008522 no 2740 0.203430115159855 3757 16871 A napthoquinone isolated from Swertia calycina. SGTC_3277 9138724 49.47 µM -0.832514200362515 0.199529422558458 no 2741 0.20255938308313 3814 15943418 SGTC_1742 st038235 28.8875 µM -0.835065788395942 0.198833066061936 no 2742 0.201840333936684 3928 564103 YBR002C RER2 SGTC_790 1575-0012 79.1 µM -0.83580700143734 0.198631055779793 no 2743 0.201631743527563 3971 378741 YLR208W SEC13 SGTC_2441 5730946 39.09 µM -0.836836695712399 0.19835062829376 no 2744 0.201342183810254 3964 1774275 SGTC_2850 9015429 58.44 µM -0.837988605831093 0.198037199779312 no 2745 0.201018551413844 3952 6457570 SGTC_406 estrone 100 µM -0.840044083802592 0.197478658893671 no 2746 0.200441834868058 3850 5870 A steroid. SGTC_2897 9048598 12.99 µM -0.841525850346778 0.197076605689149 no 2747 0.200026704742991 3875 6467404 SGTC_3352 9151559 45.5865 µM -0.842627850718989 0.19677791729677 no 2748 0.199718304919779 3882 17159339 SGTC_2370 9071495 200 µM -0.84361157671128 0.196511517954072 no 2749 0.199443246523711 3914 21791103 SGTC_2999 9069765 71.4286 µM -0.844460302782829 0.19628185316078 no 2750 0.199206118635033 3911 2097066 SGTC_2237 6667747 47.222 µM -0.849350388174982 0.19496177138049 no 2751 0.197843175244431 3896 729940 YDL015C TSC13 SGTC_1763 st044482 94.5 µM -0.84946224611548 0.194931638545144 no 2752 0.197812064737716 3939 88505 SGTC_1119 parthenolide 318.541 nM -0.850916933712344 0.194540025673893 no 2753 0.197407748750244 4033 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1125 tnp00248 1.32998 µM -0.851060475591395 0.194501409088995 no 2754 0.197367879816747 4007 24207736 SGTC_2915 7971052 15.16 µM -0.854028465170391 0.193703986860547 no 2755 0.196544608822412 3769 5741558 SGTC_2110 5483698 200 µM -0.854447701665075 0.193591509717773 no 2756 0.196428487526363 3891 2848765 YHR062C RPP1 SGTC_2077 5212015 200 µM -0.858666883295777 0.192461762493678 no 2757 0.195262163139046 3793 780900 SGTC_1654 st012436 41.8 µM -0.860064530208304 0.192088412777482 no 2758 0.194876736042428 3854 4323132 SGTC_1689 st020265 53.493 µM -0.863781641253485 0.191097629384346 no 2759 0.193853927433165 3900 5758320 YPR016C TIF6 SGTC_1877 wortmannin 25 µM -0.871135919544162 0.189146626180483 no 2760 0.191839971798866 3941 312145 A covalent inhibitor of PI 3-kinase. SGTC_3045 9092950 49.47 µM -0.871338009023231 0.189093187969479 no 2761 0.191784811409738 3885 44120432 SGTC_942 3253-1115 227 µM -0.871754175459349 0.188983171010709 no 2762 0.191671249240145 3997 46497897 SGTC_712 r015-0009 80.6 µM -0.872483021430201 0.188790589715202 no 2763 0.19147246332188 3968 6813872 YLR060W FRS1 SGTC_1758 st042942 75.2445 µM -0.875975051320004 0.18786957760816 no 2764 0.19052179843622 3855 669317 SGTC_1817 st052116 64.4 µM -0.876301735727785 0.187783557756451 no 2765 0.190433010852742 3931 4361398 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.876594642050519 0.187706452758741 no 2766 0.190353425219287 3969 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2100 5377183 190 µM -0.879102618437242 0.187047051063662 no 2767 0.189672819078664 3967 2844202 SGTC_375 3970-0961 9.27 µM -0.879516636997873 0.186938334517839 no 2768 0.189560608243362 3903 2898222 SGTC_2665 lovastatin 100 µM -0.880102907880495 0.186784453376732 no 2769 0.189401782001605 3974 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3030 9087619 49.47 µM -0.88151414655047 0.186414360878156 no 2770 0.189019800300552 3971 25236973 SGTC_542 3381-0244 89.3 µM -0.881662409276503 0.186375505871757 no 2771 0.18897969741075 3983 1112843 SGTC_422 cantharidin 155 µM -0.881688841329554 0.186368579387362 no 2772 0.188972548479163 3889 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2419 paclitaxel 166.5 µM -0.882806328707557 0.186075889208183 no 2773 0.188670460261496 3874 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1974 st069448 26.9 µM -0.882918229437521 0.186046596084096 no 2774 0.188640226757798 3936 6323587 YNR016C ACC1 SGTC_1919 st067113 52.3 µM -0.884091355250726 0.185739669928333 no 2775 0.188323449713637 4008 1268243 SGTC_474 dl-dihydrosphingosine 5 µM -0.884948913744435 0.185515504834774 no 2776 0.188092092495044 3945 3058739 A sphingolipid protein kinase C inhibitor. SGTC_237 nikkomycin 200 µM -0.884984042693541 0.185506325737362 no 2777 0.188082618940502 3946 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2636 apigenin dimethyl ether 100 µM -0.88601898935644 0.185236023527229 no 2778 0.187803647291365 3970 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2417 cerulenin 830 nM -0.887338899341429 0.184891651097103 no 2779 0.187448234290438 3981 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2447 5741742 33.78 µM -0.887556055159952 0.184835031980138 no 2780 0.187389800454327 4012 1776504 SGTC_3230 9131665 49.47 µM -0.887567265100917 0.184832109500616 no 2781 0.187386784309142 3874 15943720 SGTC_3242 9133940 49.47 µM -0.8880103542114 0.184716617279459 no 2782 0.187267590849788 3969 17248444 SGTC_2811 7967822 32.47 µM -0.89024505115574 0.184134822231608 no 2783 0.186667159514037 4024 2232244 SGTC_1973 st070275 50.2 µM -0.890283839211903 0.184124733986672 no 2784 0.186656748248507 3865 17118334 SGTC_2089 5281248 129.67 µM -0.891571866690796 0.183789931010046 no 2785 0.186311227576371 3943 2737878 SGTC_1644 st010134 20.9 µM -0.892766826165454 0.18347965897652 no 2786 0.185991027533429 3919 3818134 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.895153238937878 0.182861003089915 no 2787 0.185352588788739 4006 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2140 5586273 200 µM -0.896495261000938 0.182513668672193 no 2788 0.18499415510283 3934 854421 SGTC_1882 5615643 20 µM -0.896548740182717 0.182499836041676 no 2789 0.184979880555126 3895 2253075 SGTC_2471 5466956 24.79 µM -0.898252361293967 0.182059529527472 no 2790 0.184525511893229 3925 724419 SGTC_1143 3454-2408 5.08 µM -0.899284161343459 0.181793180602116 no 2791 0.184250660808404 3883 X1143 SGTC_2605 digitonin 300 nM -0.900520554880869 0.18147433912979 no 2792 0.183921645818773 4010 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1132 3456-3614 2.5 µM -0.9018231146483 0.181138813594188 no 2793 0.183575419460815 4068 3125502 SGTC_1041 0206-0046 107 µM -0.902702311976557 0.18091256153258 no 2794 0.183341954542481 3994 50494 SGTC_678 1218-2179 85.9 µM -0.902727207355866 0.180906157551668 no 2795 0.183335346438878 3942 6820081 YOR116C RPO31 SGTC_396 dithiazanine 1.25 µM -0.903139581875064 0.180800100761774 no 2796 0.183225909435559 3968 10578 An antihelmenthic. SGTC_3063 1327-0034 4 µM -0.903698744188767 0.180656354534358 no 2797 0.183077582602903 3878 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1945 st075991 56.6 µM -0.904192230302282 0.180529551515834 no 2798 0.18294673969037 4002 1084980 SGTC_1354 1498-1681 81 µM -0.905041238489953 0.180311526506547 no 2799 0.182721770249769 3985 5754243 SGTC_1147 3809-1045 12.3 µM -0.905844495584352 0.180105402542506 no 2800 0.182509082973722 3950 325925 SGTC_1855 st056195 39.6 µM -0.906931514081197 0.179826698151557 no 2801 0.182221507381901 3939 4028379 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.907414968232875 0.179702830771792 no 2802 0.182093698465893 3991 229346 A bile salt which induces apoptosis. SGTC_1830 st055982 50.3 µM -0.907557378025715 0.179666353713811 no 2803 0.182056060824294 3876 455313 An antimicrobial agent. SGTC_2021 4019055 173 µM -0.908091241242042 0.17952965060543 no 2804 0.181915008821986 3891 44827708 YER133W GLC7 SGTC_3120 9124077 49.47 µM -0.909101509418446 0.179271136347512 no 2805 0.181648272965138 4067 18774327 YGL155W CDC43 SGTC_1888 azatryptophan 97.5 µM -0.909276321667768 0.179226427975996 no 2806 0.181602143045223 4023 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2847 9005661 71.43 µM -0.909289001179539 0.179223185453582 no 2807 0.181598797427216 3964 2991449 SGTC_2182 6325192 200 µM -0.90983659487216 0.179083184918552 no 2808 0.181454346073558 3896 736248 SGTC_374 0880-0231 82.3 µM -0.909973935344264 0.179048082563242 no 2809 0.181418127911346 3905 6833587 SGTC_1949 st076024 69.1 µM -0.912009961747394 0.178528209796602 no 2810 0.180881736779801 3909 2921930 SGTC_1707 st032323 6.317 µM -0.913947191253026 0.17803444713636 no 2811 0.180372297514179 3869 3132057 YMR211W DML1 SGTC_2650 prasterone 100 µM -0.915233756768548 0.177707002522173 no 2812 0.180034463347566 3959 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2553 4-methylesculetin 85.09 µM -0.91710485201023 0.177231467497425 no 2813 0.179543849392975 4021 5319502 SGTC_1774 st048371 48.465 µM -0.91772644500479 0.177073668912983 no 2814 0.17938104958775 3956 4242727 SGTC_2309 7664088 163.95 µM -0.92032008572392 0.176416201424531 no 2815 0.17870275791393 4009 704922 SGTC_129 0088-0017 176.636 µM -0.920757139472165 0.176305563978352 no 2816 0.178588618346171 3829 182446 SGTC_3066 9117245 49.47 µM -0.921344120694227 0.176157042418077 no 2817 0.178435396451504 4072 17176980 SGTC_2624 nerol 100 µM -0.921409370362175 0.176140537442431 no 2818 0.178418369203742 3898 637566 A natural product oil. SGTC_2938 9059746 27.26 µM -0.922356704187859 0.175901018585771 no 2819 0.178171272732134 4013 6471769 SGTC_2890 9046729 58.44 µM -0.924183872810249 0.175439629865329 no 2820 0.177695295376807 3930 903329 SGTC_562 3772-2733 112 µM -0.924450745797621 0.175372304518026 no 2821 0.177625842182345 4018 2876874 YIL048W NEO1 SGTC_1625 st003711 30.1 µM -0.924706410211533 0.175307822176748 no 2822 0.177559322066601 4086 24207034 YER133W GLC7 SGTC_1054 3429-0080 167 µM -0.925908790793187 0.175004765677482 no 2823 0.177246691226769 4050 1162877 SGTC_137 0438-0332 85.389 µM -0.927051202125823 0.174717132389767 no 2824 0.176949975248618 3991 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1451 4152-0210 104 µM -0.927220594264036 0.174674508851607 no 2825 0.176906006138205 4004 659563 SGTC_2038 4100038 30.985 µM -0.928586395479743 0.174331078424582 no 2826 0.176551737491356 4006 3596803 SGTC_186 3455-3465 67.277 µM -0.929337862410964 0.174142305305309 no 2827 0.176357009562127 3958 755278 SGTC_2751 anetholtrithion 17.25 µM -0.929494066594938 0.174103082168998 no 2828 0.176316549374375 4035 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3304 9125678 46.087 µM -0.930290675625537 0.173903139640746 no 2829 0.17611030215168 3948 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1220 1838-0075 193 µM -0.93109161076324 0.1737022585638 no 2830 0.175903088907455 3928 5529645 SGTC_1229 0139-0193 12.2 µM -0.931360548100764 0.17363484000126 no 2831 0.175833545657026 4071 3090752 SGTC_2913 7966556 36.57 µM -0.932190450822522 0.173426900795084 no 2832 0.175619054789133 3864 2976516 SGTC_967 1306-0166 352 µM -0.932231204446776 0.173416693711615 no 2833 0.175608526164245 3976 4437607 SGTC_128 0906-2981 13.371 µM -0.934405671238882 0.172872635044365 no 2834 0.175047336714497 3948 6740226 SGTC_2900 5328528 85.29 µM -0.936851036901205 0.172262097518137 no 2835 0.17441759410903 4022 795359 SGTC_3212 9128307 49.47 µM -0.937869483181541 0.172008227069297 no 2836 0.174155743846487 3977 27243542 SGTC_701 4424-0219 185 µM -0.938246742813104 0.171914247347698 no 2837 0.174058810985633 4066 2911779 SGTC_1833 st055984 71 µM -0.93878543737862 0.171780109167221 no 2838 0.173920458595626 4052 676288 SGTC_1620 st003704 16.5 µM -0.94177794466372 0.1710361744255 no 2839 0.173153169639277 3945 2834414 SGTC_248 streptozotocin 5.23457 mM -0.942726087571945 0.170800897471273 no 2840 0.172910513040619 4032 5300 DNA alkylating agent. SGTC_2654 protoveratrine a 100 µM -0.944873024337706 0.170268911669999 no 2841 0.172361852465539 4012 5702278 A heart drug and vasodilator. SGTC_126 0417-1624 672.48 µM -0.9468134540388 0.169789010204108 no 2842 0.17186692240703 4076 41912 YDL195W SEC31 SGTC_1113 artemisinin 1.17947 µM -0.946853648793419 0.169779078532131 no 2843 0.171856679852189 4066 2240 An anti-malaria and mitochondrial poison. SGTC_1335 1486-0900 202 µM -0.948036419359688 0.16948699600856 no 2844 0.171555457013892 4023 X1335 SGTC_695 3505-6186 243 µM -0.948755300098183 0.169309627668464 no 2845 0.171372540546945 4047 1819379 SGTC_3175 9106517 49.47 µM -0.949780877195505 0.169056794924235 no 2846 0.171111802235732 4052 41468073 SGTC_1920 st075728 45.7 µM -0.950608404722691 0.168852963660575 no 2847 0.170901600249352 3973 3400306 SGTC_1023 4482-3888 16 µM -0.951416968347998 0.168653956041508 no 2848 0.170696374975911 4065 3303168 SGTC_2166 5933061 31.504 µM -0.953999340400009 0.168019380135619 no 2849 0.170041988130742 4124 2877375 SGTC_33 0986-0033 35.816 µM -0.9548123315784 0.167819919233047 no 2850 0.169836305063969 3957 2848082 SGTC_1978 st071761 42 µM -0.956253905192138 0.167466615632656 no 2851 0.169471985912827 4063 5147680 SGTC_2303 7774051 200 µM -0.956391528527448 0.167432911721049 no 2852 0.169437231540153 4060 2953184 SGTC_1180 1193-0155 285 µM -0.956594749119681 0.167383151054405 no 2853 0.169385920088588 4116 2921347 SGTC_47 0149-0135 24.25 µM -0.957153409976076 0.167246406272407 no 2854 0.169244914425162 4066 5239155 SGTC_2876 9059903 25.97 µM -0.959053650889206 0.166781818863855 no 2855 0.168765859038529 3988 6916095 SGTC_1961 st076550 68.7 µM -0.961935019998147 0.166078946809195 no 2856 0.168041122929527 4078 1579337 SGTC_1322 1348-1070 12 µM -0.964630104077296 0.165423251334099 no 2857 0.167365057758073 4042 6758089 SGTC_5 0352-0601 109.883 µM -0.965000056357498 0.165333375384563 no 2858 0.167272391777437 3978 762456 SGTC_3221 9128209 49.47 µM -0.967203401329006 0.164798750901411 no 2859 0.166721181092532 4089 16460723 SGTC_359 0081-0058 15.9 µM -0.967289095004196 0.164777980647228 no 2860 0.166699766815822 4148 3494159 SGTC_1889 st059080 5.18 µM -0.967613196194937 0.164699441012361 no 2861 0.166618792145711 3968 176925 Isolated from Daphnopsis sellowiana. SGTC_1273 0849-0096 14.1 µM -0.967616100966889 0.164698737206919 no 2862 0.166618066521273 4068 5286025 SGTC_912 3474-0017 2.18 µM -0.969740764111147 0.164184468510369 no 2863 0.166087862938725 4104 3360550 SGTC_1794 st048918 76.9 µM -0.971300678624746 0.163807559337508 no 2864 0.165699285481368 3947 672303 SGTC_3109 9122853 49.47 µM -0.973703513520515 0.163228081967941 no 2865 0.165101886132317 4108 1234709 SGTC_1447 4239-0816 81.9 µM -0.976271168262699 0.16261033000358 no 2866 0.164465051826451 4069 1341554 SGTC_2397 5161689 200 µM -0.976518249538342 0.162550965057332 no 2867 0.164403854378617 4123 2259942 SGTC_668 1682-0499 62.6 µM -0.978308795715182 0.162121181176358 no 2868 0.163960810487239 4049 682214 SGTC_844 0330-0132 15.3 µM -0.978420721865436 0.162094340196566 no 2869 0.163933141783453 4111 2828079 SGTC_209 4077-0173 175.592 µM -0.980398736092478 0.161620470675585 no 2870 0.163444666703715 4043 15993494 SGTC_1383 3049-0032 20.7 µM -0.980641532534238 0.161562366630969 no 2871 0.163384772783332 4133 712864 SGTC_2297 7971671 152.32 µM -0.984424912269341 0.160658719074653 no 2872 0.162453317039252 4084 909016 SGTC_1815 st051655 58.2 µM -0.985270885034727 0.160457113758102 no 2873 0.162245514989842 4030 5984156 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.985526629850444 0.160396199295152 no 2874 0.162182728730776 4086 5024745 SGTC_2511 berberine 10.47 µM -0.986161410725161 0.160245069609005 no 2875 0.162026956152766 4052 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2207 7258803 200 µM -0.986737866588265 0.16010790670602 no 2876 0.161885580747886 4037 3666799 SGTC_1115 galangin 695.678 nM -0.986965066700231 0.160053867414485 no 2877 0.161829882163158 4129 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3247 9135149 49.47 µM -0.98758728913073 0.159905933570915 no 2878 0.161677406960887 4064 8934436 YOR116C RPO31 SGTC_2713 st079149 53.4 µM -0.988786773794445 0.159621007659164 no 2879 0.161383738350089 4103 3103253 SGTC_1560 lithocholic acid 53.1 µM -0.990966551403022 0.159104073735756 no 2880 0.160850956690791 3952 9903 A bile acid which acts as a detergent. SGTC_643 k048-0106 28.4 µM -0.995672859002719 0.157991717937356 no 2881 0.159704560714565 4089 6763920 SGTC_886 0866-0150 153 µM -0.995713171365983 0.157982212046702 no 2882 0.159694764290976 4151 271463 SGTC_2848 9016370 25.97 µM -0.996563397999398 0.157781811121148 no 2883 0.159488239869968 4067 7894410 SGTC_680 0417-1641 114 µM -0.997514027540413 0.157557942725019 no 2884 0.159257534184553 4058 2835990 SGTC_1498 4478-3555 97.6 µM -0.997712941664858 0.157511125884107 no 2885 0.159209287923647 4044 3437919 SGTC_2453 5731132 22.18 µM -1.00018201931358 0.156930759723219 no 2886 0.158611214594643 4138 1362040 SGTC_1740 st038286 13.222 µM -1.00168288394319 0.156578664119989 no 2887 0.158248387926728 4150 716786 SGTC_3049 9092223 49.47 µM -1.00183372520694 0.156543306270682 no 2888 0.158211952933442 4071 8623917 SGTC_77 0828-0286 12.516 µM -1.00221022338813 0.156455076394171 no 2889 0.158121035600473 4009 745345 SGTC_1946 st076057 65.1 µM -1.00410249120116 0.156012131825958 no 2890 0.157664607393633 4037 953009 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.00488894320189 0.155828281467888 no 2891 0.157475164555028 4073 6312947 SGTC_202 3594-0513 34.79 µM -1.00580534592138 0.155614232557642 no 2892 0.157254607603571 4105 708429 SGTC_211 3455-0679 143.504 µM -1.00602843355685 0.155562154193641 no 2893 0.157200946320776 4146 748649 SGTC_3262 9137218 49.47 µM -1.01097022635999 0.154411472994169 no 2894 0.156015340107835 3981 17650664 SGTC_85 0868-0259 160.055 µM -1.01148251830821 0.154292510130774 no 2895 0.15589277201286 4029 83173 SGTC_634 1611-4317 11.2 µM -1.01269028062524 0.154012287211483 no 2896 0.155604060885189 4124 2843522 SGTC_135 0933-0004 26.348 µM -1.01481735123562 0.153519587214467 no 2897 0.155096450556268 4088 21230617 YGL099W LSG1 SGTC_853 0419-0306 21 µM -1.01498624326092 0.153480511010641 no 2898 0.155056192576271 4128 762713 SGTC_1782 st039423 80.636 µM -1.01704664971535 0.153004329398759 no 2899 0.154565618979058 4136 2068169 SGTC_1642 st009582 77.7 µM -1.01739935937971 0.152922912769126 no 2900 0.154481743325743 4102 6739311 SGTC_2056 5235370 200 µM -1.01777256645379 0.152836795967341 no 2901 0.15439302608028 4054 5511916 SGTC_1 0258-0098 57.368 µM -1.01983942292461 0.152360455208691 no 2902 0.153902311446446 4063 6790032 YDR047W HEM12 SGTC_1388 3346-4487 254 µM -1.02186833342014 0.151893819164976 no 2903 0.153421610963302 4170 3345614 SGTC_687 k029-0044 34.9 µM -1.02387758504651 0.151432641217809 no 2904 0.152946549336741 4199 5829338 SGTC_685 1278-0033 54.9 µM -1.02523557411654 0.15112147359733 no 2905 0.152626023259358 4180 3590572 SGTC_741 4582-0002 126 µM -1.02602365806851 0.15094108841354 no 2906 0.152440216345747 4098 2912688 SGTC_2009 4012297 12.05 µM -1.02733245655785 0.150641833198245 no 2907 0.152131972133536 4130 45595307 SGTC_1407 3909-7909 12.3 µM -1.0281750548503 0.150449383311294 no 2908 0.151933745121316 4115 4411780 SGTC_1474 0330-0125 5.35 µM -1.02999291216381 0.150034741864293 no 2909 0.151506666407127 4135 X1474 SGTC_1501 4491-0275 38.4 µM -1.03072381817141 0.149868241911376 no 2910 0.151335176029356 4090 5104718 SGTC_2780 5215298 71.43 µM -1.03099750165835 0.14980592869932 no 2911 0.151270995691591 4164 2834131 SGTC_3053 9095903 49.47 µM -1.03196469755846 0.149585852631435 no 2912 0.151044327803023 4218 17174018 SGTC_809 3998-0021 90 µM -1.03213927124418 0.149546153075002 no 2913 0.151003439552933 4074 715485 SGTC_564 3555-0129 330 µM -1.03214008697505 0.149545967587299 no 2914 0.151003248511604 3954 563260 SGTC_1333 1482-0047 286 µM -1.03427494899608 0.14906105079864 no 2915 0.150503822287131 4145 3811116 SGTC_169 k015-0017 16.025 µM -1.03508592090316 0.148877120613696 no 2916 0.15031439351501 4079 1840002 SGTC_3083 9117465 49.47 µM -1.03533445183115 0.148820783633508 no 2917 0.150256372881439 4121 16420915 SGTC_895 0964-0006 13.7 µM -1.03607268714485 0.148653524504867 no 2918 0.150084116638355 4093 6738897 SGTC_2001 4023502 57.655 µM -1.03791969734918 0.148235605225496 no 2919 0.149653721190977 4167 108941 YCR052W RSC6 SGTC_65 0798-0905 34.986 µM -1.04174921191258 0.147371615324409 no 2920 0.148763983225805 4245 3602145 SGTC_2274 7947094 46.08 µM -1.04469087781391 0.146710232227663 no 2921 0.148082931131095 4093 2971028 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.04597260818998 0.146422681036898 no 2922 0.147786839625533 4192 23847180 SGTC_1989 st071868 50.2 µM -1.04610562230288 0.146392861526747 no 2923 0.147756134862625 4121 16414057 SGTC_2771 fluoxetine 41.05 µM -1.04940848141363 0.145653723997199 no 2924 0.146995078163674 4160 3386 A selective serotonin reuptake inhibitor. SGTC_1387 3342-1166 1.8 µM -1.04945263193199 0.14564386070113 no 2925 0.14698492267934 4104 3418228 SGTC_1393 3470-5649 58.2 µM -1.05121182706467 0.145251219121515 no 2926 0.146580656202608 4119 4108395 SGTC_2867 9039098 71.43 µM -1.05203228961354 0.145068340670247 no 2927 0.146392367721975 4093 6463460 SGTC_757 1066-0008 322 µM -1.05247038092894 0.144970755026445 no 2928 0.146291896393031 4178 6842497 SGTC_2132 5317594 122.667 µM -1.05370949700889 0.144694978957936 no 2929 0.146007969771566 4101 794577 SGTC_1324 1418-0026 34.4 µM -1.05379883850838 0.144675108895424 no 2930 0.145987512699528 4179 1372513 SGTC_141 0443-0274 32.331 µM -1.05383328072057 0.144667449240527 no 2931 0.145979626768939 4144 1627241 SGTC_1075 aripiprazole 15.2 µM -1.05456319349879 0.144505187083851 no 2932 0.145812572361431 4185 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1384 3089-0840 101 µM -1.05612234638402 0.144158992830729 no 2933 0.145456161123195 4144 1069836 SGTC_2606 farnesol 9.78 µM -1.0571964045724 0.143920834536516 no 2934 0.145210980198236 4194 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_535 2293-4129 48.2 µM -1.05883613435585 0.143557758124259 no 2935 0.144837207068639 4165 396118 YIL048W NEO1 SGTC_383 2324-0395 7.37 µM -1.05953797822957 0.143402541779452 no 2936 0.144677421321677 4154 3146421 SGTC_2926 9010726 65.15 µM -1.0607762818318 0.143128961054692 no 2937 0.144395791769169 4187 2994293 SGTC_2348 9022543 33.42 µM -1.06247547472279 0.142754129396485 no 2938 0.144009943048737 4192 3162678 YDL140C RPO21 SGTC_1591 genipin 88.4 µM -1.06282932546902 0.142676155625504 no 2939 0.143929679016028 4188 442424 A DNA cross-linking agent. SGTC_2992 9074591 71.4286 µM -1.06467748947855 0.14226936629952 no 2940 0.143510950060016 4119 17741321 SGTC_761 k216-0224 480 µM -1.06533148046558 0.142125608066278 no 2941 0.143362975885394 4197 1340404 SGTC_32 0928-0142 34.1 µM -1.06829560412116 0.141475276660825 no 2942 0.142693595387233 4152 2244242 SGTC_3108 9121785 49.47 µM -1.07016456503814 0.141066263106003 no 2943 0.142272620619903 3995 17140271 SGTC_2806 7952793 58.44 µM -1.07322833543387 0.140397507243306 no 2944 0.141584340107677 4230 2972490 SGTC_2928 9011484 9.79 µM -1.07795335399917 0.139370362429228 no 2945 0.140527286660874 4185 2994751 SGTC_2592 piperlongumine 83.33 µM -1.07863964811799 0.139221599153645 no 2946 0.140374199708157 4193 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_465 cgp-37157 41 µM -1.08114568285856 0.138679301084402 no 2947 0.139816157598927 4125 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_44 0929-0055 61.211 µM -1.08166084605316 0.138567999927286 no 2948 0.139701628527274 4074 1379590 SGTC_2545 solidagenone 89.61 µM -1.08743714082933 0.137324196690904 no 2949 0.138421832275227 4017 6708572 An anti ulcer agent SGTC_2173 5763948 167 µM -1.08836071801641 0.137126033041528 no 2950 0.138217947744003 4158 2867177 SGTC_3104 9120930 49.47 µM -1.08932916588035 0.13691845181349 no 2951 0.138004377781998 4211 17014836 SGTC_323 4013-0906 34.3 µM -1.08939752724517 0.136903807067336 no 2952 0.137989310689819 4202 2910086 SGTC_823 0417-1665 178 µM -1.0897776065279 0.136822403923558 no 2953 0.137905560301722 4173 3429856 SGTC_2374 9071832 200 µM -1.08997178596552 0.136780828486414 no 2954 0.137862786290313 4118 17381698 SGTC_1111 tnp00062 510.699 nM -1.09183345926682 0.136382667012743 no 2955 0.137453154692083 4229 676306 SGTC_3336 9143619 71.43 µM -1.09320653540487 0.136089511777916 no 2956 0.137151564122485 4222 45595730 SGTC_1643 st009866 20.2 µM -1.09412480206309 0.135893700368018 no 2957 0.136950123028318 4136 3156273 YOR207C RET1 SGTC_932 2857-0803 154 µM -1.09808364504073 0.135051724978125 no 2958 0.136083983123787 4241 674898 SGTC_1647 st011722 22.4 µM -1.09977564529206 0.134692960245003 no 2959 0.1357149431391 4163 2854783 SGTC_1710 st031758 61.5 µM -1.10032083139491 0.134577500687697 no 2960 0.13559617946156 4222 5394341 SGTC_1217 1183-1422 255 µM -1.1005155335536 0.13453628311644 no 2961 0.135553782683148 4225 2849664 SGTC_3238 9133470 49.47 µM -1.10089281394224 0.134456439221944 no 2962 0.135471654989432 4186 3534688 SGTC_2467 5474540 200 µM -1.10101728506089 0.13443010452243 no 2963 0.135444567169801 4151 5413519 SGTC_3314 9135860 59.4275 µM -1.10475234191645 0.133641515431996 no 2964 0.134633458162168 4190 25252478 SGTC_1372 2752-0194 270 µM -1.10480901705712 0.133629574059835 no 2965 0.134621176258035 4125 823334 SGTC_2719 novobiocin 32.65 µM -1.10482576189337 0.133626046086877 no 2966 0.134617547680667 4228 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1265 0819-1001 68.8 µM -1.10534740532512 0.133516173000008 no 2967 0.134504542059287 4157 3106768 SGTC_950 1165-0508 94.1 µM -1.10647860733747 0.133278122875385 no 2968 0.134259709201652 4223 6148369 SGTC_1724 st037281 8.293 µM -1.10825734134722 0.132904397049158 no 2969 0.133875346462049 4174 574124 YDL195W SEC31 SGTC_1645 Cervolide 78 µM -1.10851536688997 0.132850243863721 no 2970 0.133819653159658 4198 23173 A fragrance. SGTC_253 dyclonine 31.25 µM -1.10873285347396 0.132804610606172 no 2971 0.133772722324558 4298 3180 An oral anasthetic. SGTC_2499 avocadenofuran 51.48 µM -1.11227272883698 0.132063387794138 no 2972 0.133010452829436 4179 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1194 1488-0194 225 µM -1.11282217791866 0.13194859362756 no 2973 0.132892404199424 4150 1391452 SGTC_1348 1493-0373 93.8 µM -1.11586024416807 0.1313151052311 no 2974 0.132240980755476 4210 3010129 SGTC_2779 methotrexate 400 µM -1.11586372957593 0.13131437967254 no 2975 0.132240234679208 4229 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1281 0884-0031 11.8 µM -1.11735148416075 0.131004926046857 no 2976 0.131922035197228 4229 1548255 SGTC_2029 5175081 200 µM -1.11904097842159 0.130654121890452 no 2977 0.131561328700236 4177 1380876 SGTC_4 0960-0234 25.671 µM -1.11978477932925 0.130499886227329 no 2978 0.131402743454343 4222 6821112 SGTC_2190 6049624 200 µM -1.12076408691278 0.130297007645056 no 2979 0.131194147353835 4089 2265554 SGTC_2981 9013952 38.96 µM -1.1239374591267 0.12964109451819 no 2980 0.130519779298364 4189 2996344 SGTC_1197 1601-0112 267 µM -1.12592457268493 0.129231538837689 no 2981 0.130098723649842 4189 7350313 SGTC_2361 9034121 116 µM -1.13248993660789 0.127884759646746 no 2982 0.128714256427056 4230 6496917 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.13445112988145 0.127484350858421 no 2983 0.128302681054975 4270 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3227 9130768 49.47 µM -1.13526815575913 0.127317799548496 no 2984 0.128131490201085 4276 17720899 SGTC_904 1141-0088 396 µM -1.13783225325047 0.126796089534577 no 2985 0.12759526715595 4236 1378119 SGTC_980 1473-0395 201 µM -1.13860923472929 0.126638293472223 no 2986 0.12743308749215 4108 768876 SGTC_3239 9133757 49.47 µM -1.14077723399726 0.126198720988174 no 2987 0.126981318388801 4259 17036923 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.14249404966384 0.125851383551557 no 2988 0.126624358995167 4328 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1610 st001799 48.1 µM -1.14273496305781 0.125802696572536 no 2989 0.12657432438245 4162 621897 SGTC_2475 5812728 15.03 µM -1.14666551599404 0.125010213522519 no 2990 0.125759943852249 4161 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_815 1582-0027 36.9 µM -1.14907318594849 0.124526501812103 no 2991 0.125262901988726 4273 3128206 SGTC_2385 9074692 200 µM -1.14918429965052 0.124504210201315 no 2992 0.125239996717862 4266 17046906 SGTC_806 3966-4455 5.86 µM -1.14921055450892 0.124498943363897 no 2993 0.125234584899447 4226 714982 SGTC_2136 5328288 199.296 µM -1.14934237279436 0.124472502403768 no 2994 0.125207416143877 4224 262395 SGTC_2356 9061756 188.97 µM -1.15194985728357 0.123950283231981 no 2995 0.124670839422214 4271 20104043 SGTC_3097 9117246 49.47 µM -1.15270070465988 0.12380019052198 no 2996 0.124516626061653 4257 16423892 SGTC_435 c-PAF 6.7 µM -1.15319722437469 0.123701007255861 no 2997 0.124414721265837 4222 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2852 9023854 51.95 µM -1.15378326016392 0.123584014134032 no 2998 0.124294519409767 4285 19798528 SGTC_1222 0366-0074 1.18 µM -1.15640646954717 0.123061280134645 no 2999 0.123757468286405 4257 286520 SGTC_2227 7312221 64.1025 µM -1.15860474655965 0.122624418746481 no 3000 0.123308666616401 4347 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2373 9071805 200 µM -1.15875582775882 0.122594434537081 no 3001 0.123277863714649 4275 10149009 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.15930106925147 0.122486266400201 no 3002 0.123166743036517 4272 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1999 st074831 12.5 µM -1.16057463717809 0.122233869640505 no 3003 0.122907462349118 4215 17112523 SGTC_860 0443-0016 25.1 µM -1.1618995457878 0.121971685868891 no 3004 0.122638135831623 4277 5337942 SGTC_1077 5-fluorocytosine 377 nM -1.16315522476444 0.121723566622446 no 3005 0.122383264648922 4307 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1568 digitonin 820 nM -1.16423067515506 0.121511342257925 no 3006 0.122165271057807 4240 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2264 7948757 110.76 µM -1.16519349761488 0.121321564144271 no 3007 0.121970338548657 4222 2971411 SGTC_2405 ticlatone 3.52 µM -1.16867862328088 0.120636367808922 no 3008 0.121266568866267 4092 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3244 9134489 49.47 µM -1.1701629191293 0.120345375295396 no 3009 0.12096770601011 4267 16584271 SGTC_3243 9134147 49.47 µM -1.17048209581736 0.120282866145146 no 3010 0.120903507569997 4363 24282180 SGTC_97 0535-0701 19.132 µM -1.17481735843299 0.119436091430834 no 3011 0.120033896959804 4165 2832013 YGL099W LSG1 SGTC_3283 9109332 35.8195 µM -1.17567900324742 0.119268295013013 no 3012 0.119861586047821 4106 17027281 SGTC_2282 7944268 200 µM -1.17662572113865 0.119084123400405 no 3013 0.119672463455191 4281 2970414 SGTC_1009 4106-0057 9.87 µM -1.17877213866766 0.118667309774462 no 3014 0.119244460704625 4265 2928005 SGTC_746 1095-0025 46.6 µM -1.1791774068611 0.118588726417359 no 3015 0.119163770291962 4286 6749286 SGTC_3019 9081971 49.47 µM -1.17943331159995 0.118539124262567 no 3016 0.119112838559134 4290 16451803 SGTC_616 4092-0450 108 µM -1.17987061751993 0.118454394957191 no 3017 0.119025838822881 4261 787165 SGTC_1898 st060199 18.6 µM -1.18109842646111 0.118216732211944 no 3018 0.11878181248797 4245 688866 SGTC_1323 1348-1351 11.2 µM -1.18203604036869 0.118035468714794 no 3019 0.118595700389961 4240 6989654 SGTC_1312 1218-2183 165 µM -1.18217054155122 0.118009482507821 no 3020 0.118569019425679 4324 6744073 SGTC_1546 5-methoxyflavanone 78.7 µM -1.18307515712081 0.11783481202591 no 3021 0.118389681272612 4276 147795 SGTC_571 k831-0106 44.2 µM -1.1883450007705 0.116820904821603 no 3022 0.117348757632035 4160 4783639 SGTC_641 4092-0595 30 µM -1.19142336793923 0.11623150255465 no 3023 0.116743711903056 4324 786260 SGTC_1118 chelidonine 707.474 nM -1.19413027680373 0.115714968144043 no 3024 0.116213505725953 4264 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3313 9133968 57.047 µM -1.19444774113523 0.115654496346412 no 3025 0.116151435661401 4272 1494643 SGTC_1380 2291-0730 164 µM -1.20730047716597 0.113225085512869 no 3026 0.11365822349428 4298 2999191 SGTC_1085 doxorubicin 7.67 µM -1.21698926729779 0.111417943034978 no 3027 0.11180414970308 4316 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_471 1-acyl-paf 4 µM -1.21752992357111 0.111317712040719 no 3028 0.111701329204677 4245 16759367 SGTC_291 SEC14.278 35.5 µM -1.22134733317621 0.110611847918047 no 3029 0.110977269512997 4334 1068044 SGTC_1011 4112-3381 17.4 µM -1.22150982568769 0.110581873330477 no 3030 0.110946523832969 4356 2877139 SGTC_2954 9074818 52.69 µM -1.22281053332068 0.11034214486146 no 3031 0.110700633047009 4331 16648742 SGTC_2790 5423970 71.43 µM -1.22854499114358 0.109289692120119 no 3032 0.109621225444539 4350 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_563 tetrahydrosecaminediol 614 µM -1.23227663534449 0.108608703384262 no 3033 0.108922882294905 4364 334274 A psychoactive constituent of the cannabis plant. SGTC_2962 9082311 13.18 µM -1.23497458323184 0.108118258777985 no 3034 0.108419981826589 4295 16459453 SGTC_1350 1495-0454 146 µM -1.23653333925726 0.107835629099011 no 3035 0.108130190541777 4354 1069057 SGTC_654 1124-0271 80.9 µM -1.23779469586952 0.107607312959748 no 3036 0.107896097840565 4294 5403748 SGTC_1282 0886-0010 32.4 µM -1.24011987650105 0.10718734899742 no 3037 0.107465529088127 4338 2836211 YNL267W PIK1 SGTC_3115 9123671 49.47 µM -1.24090387575076 0.107046013260559 no 3038 0.107320630415808 4455 3286988 SGTC_2375 9072683 200 µM -1.24121349505618 0.106990233573237 no 3039 0.107263445415339 4388 16798029 SGTC_1316 1272-0050 65.9 µM -1.24125825974242 0.106982170694272 no 3040 0.107255179439525 4281 7340392 SGTC_2482 5981709 142.65 µM -1.24249720836054 0.106759188955954 no 3041 0.107026584924197 4250 877755 SGTC_2601 securinine 100 µM -1.24270816383569 0.106721255349206 no 3042 0.106987697230505 4306 442872 A GABA receptor antagonist. SGTC_478 N-arachidonylglycine 10 µM -1.24445788281563 0.106406999138159 no 3043 0.106665545502454 4312 5283389 SGTC_890 0929-0006 47.2 µM -1.24649604523291 0.106041780535414 no 3044 0.106291170103958 4318 1378169 SGTC_2880 9042983 58.44 µM -1.24747407364192 0.105866849435232 no 3045 0.106111860429252 4284 6464714 SGTC_1739 st037196 92.5 µM -1.2484408403579 0.105694137688045 no 3046 0.105934830324314 4372 612214 SGTC_1609 st001574 46.4 µM -1.25707395119471 0.104160868091433 no 3047 0.104363429295305 4332 3960012 SGTC_2526 patulin 37.61 µM -1.25788085778362 0.104018387020534 no 3048 0.104217423738442 4360 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1311 1190-0148 100 µM -1.26015131362034 0.103618235347048 no 3049 0.103807391109264 4392 1961333 SGTC_2344 7990960 76.95 µM -1.26116841290887 0.103439341560692 no 3050 0.103624088229223 4312 140813 SGTC_2006 4011487 200 µM -1.26183204783449 0.103322738219064 no 3051 0.103504613814049 4334 45595294 SGTC_1968 st069590 43.6 µM -1.26335855642185 0.103054886753559 no 3052 0.103230175500241 4292 6384066 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.26659688422112 0.102488338548083 no 3053 0.102649733561464 4312 16623 A steroid. SGTC_771 0250-0039 27.3 µM -1.26779184701954 0.10227985181786 no 3054 0.102436147242432 4304 3005115 SGTC_1182 1222-0449 220 µM -1.27076560626673 0.101762355508039 no 3055 0.101906023942846 4337 658318 SGTC_476 mead acid 10 µM -1.27092123172306 0.10173532600559 no 3056 0.101878336134924 4388 5312531 An omega 9 fatty acid. SGTC_2210 7115885 190.385 µM -1.2717788297776 0.101586469527128 no 3057 0.101725856422006 4431 2927039 SGTC_2394 5221648 200 µM -1.27340552830707 0.101304553290556 no 3058 0.101437088332995 4376 788586 SGTC_1875 nocodazole 6 µM -1.27569954350852 0.100907956562608 no 3059 0.101030875011258 4370 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3272 9137413 49.47 µM -1.28110508698199 0.099977907687001 no 3060 0.100078378661799 4267 17614870 SGTC_3082 9117008 49.47 µM -1.28364240954737 0.0995435147379834 no 3061 0.0996335518050513 4387 41448529 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.28535475170609 0.0992511400691808 no 3062 0.0993341727119639 4368 61125 An anti-inflammatory. SGTC_608 k048-0125 159 µM -1.28917205822239 0.0986016134381031 no 3063 0.0986691383700483 4391 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2014 4013930 200 µM -1.29214703236206 0.0980975738252043 no 3064 0.098153115386221 4329 64556 SGTC_595 3909-8003 73.7 µM -1.29419400278785 0.0977518606802155 no 3065 0.0977992088952727 4421 699517 SGTC_2272 7805186 180 µM -1.29722795754841 0.0972410998855587 no 3066 0.0972763819587067 4385 2956062 YPR165W RHO1 SGTC_324 1315-0088 19.6 µM -1.30336537163503 0.0962138698558065 no 3067 0.0962250264020315 4327 6787421 SGTC_1042 0350-0096 82 µM -1.30502231116679 0.0959379172542565 no 3068 0.0959426253352525 4367 3122515 SGTC_313 3474-0040 5.03 µM -1.30617381058049 0.0957464855529183 no 3069 0.0957467284221038 4376 1043375 YIL048W NEO1 SGTC_393 acivicin 6.25 µM -1.30651179321421 0.0956903508112595 no 3070 0.0956892855901252 4227 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_851 0394-0702 453 µM -1.31318467348946 0.0945870213586164 no 3071 0.094560363596415 4384 762646 SGTC_1690 st023502 41.2 µM -1.3138324521507 0.0944804156334525 no 3072 0.0944512970544158 4381 24207482 SGTC_1885 st057546 99.9 µM -1.31887754463198 0.0936531688394358 no 3073 0.0936050272157818 4419 702008 SGTC_3275 9138069 49.47 µM -1.31910330651723 0.0936162759425553 no 3074 0.093567288955714 4449 17617007 SGTC_745 0469-0705 296 µM -1.31971729987154 0.0935159944512063 no 3075 0.0934647109224744 4421 3486736 SGTC_3184 9108758 49.47 µM -1.32780080276765 0.0922031325275574 no 3076 0.0921219608450348 4400 902885 SGTC_2991 9074669 71.4286 µM -1.32826956884339 0.0921274197200641 no 3077 0.0920445345371473 4353 17333109 SGTC_416 estradiol valerate 100 µM -1.32846142693715 0.0920964450153949 no 3078 0.0920128591476209 4395 13791 A steroid. SGTC_1906 st060206 94.7 µM -1.33232893484417 0.091473694955984 no 3079 0.091376061522638 4415 5133468 SGTC_101 0490-5701 117.494 µM -1.33792128880982 0.0905787356783502 no 3080 0.0904610482828183 4249 4661669 SGTC_173 1273-0061 2.693 µM -1.34150173754512 0.090009169811673 no 3081 0.0898788029816081 4356 2847414 YPL266W DIM1 SGTC_1152 3909-8331 15.9 µM -1.34468059664304 0.0895057215271569 no 3082 0.0893642016431204 4366 16001939 SGTC_794 k038-0031 316 µM -1.34512725159821 0.0894351511763213 no 3083 0.0892920720377696 4388 6624242 SGTC_2266 7929956 200 µM -1.34766180967069 0.0890354810028698 no 3084 0.08888359032818 4339 2967153 SGTC_252 miconazole 1.30953 nM -1.34782336711426 0.0890100504253891 no 3085 0.0888576001892921 4294 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2564 betulinic acid 100 µM -1.35001684886504 0.0886653117547826 no 3086 0.0885052891910986 4436 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_365 0121-0052 13.6 µM -1.35218922790152 0.088324870804403 no 3087 0.0881573944050473 4411 3101739 SGTC_1465 k213-0056 144 µM -1.35253793496344 0.0882703145841358 no 3088 0.0881016459304537 4292 24048857 YMR208W ERG12 SGTC_2478 5763493 32.33 µM -1.35500698532448 0.0878847428760782 no 3089 0.0877076657408396 4340 1365576 YLR208W SEC13 SGTC_2871 9038510 12.99 µM -1.35861601585133 0.0873234115472243 no 3090 0.0871341486929024 4390 4945164 SGTC_3085 9117376 49.47 µM -1.36386056855372 0.0865124758985073 no 3091 0.0863057265683858 4490 16480349 SGTC_516 3992-2719 87.3 µM -1.36398292396346 0.0864936242048129 no 3092 0.0862864700387211 4312 5350887 YDR037W KRS1 SGTC_538 2922-0838 53.3 µM -1.36587709701308 0.0862021745000171 no 3093 0.0859887712301507 4425 777039 SGTC_98 0074-0023 107.663 µM -1.36988885628332 0.0855873257570039 no 3094 0.0853607994201693 4421 3563821 SGTC_2656 pseudo-anisatin 100 µM -1.37795904327799 0.0843604323958113 no 3095 0.0841079668806947 4476 6708809 A neurotoxin. SGTC_327 1273-0057 3.96 µM -1.37967561558644 0.0841011761137596 no 3096 0.0838432720180065 4325 3108138 SGTC_193 1273-0060 1.558 µM -1.38117131696106 0.0838757663159332 no 3097 0.0836131458762964 4253 2847393 YHR072W ERG7 SGTC_1928 4'-methoxychalcone 40.3 µM -1.38250154849472 0.0836756751420764 no 3098 0.0834088776710459 4441 641818 SGTC_2211 7117706 200 µM -1.3836386871763 0.0835049131538518 no 3099 0.0832345580532035 4364 822771 SGTC_2170 morpholine 200 µM -1.38408938414847 0.0834373053484845 no 3100 0.0831655435377368 4462 121171 Reacts with secondary amines. SGTC_1640 st009078 66.4 µM -1.3873858664823 0.0829440595359174 no 3101 0.0826620661908593 4397 690618 SGTC_1578 josamycin 24.2 µM -1.39087231081021 0.082424780161403 no 3102 0.0821320753082264 4413 5282165 A P450 substrate. SGTC_2428 5615643 7.78 µM -1.39100794642149 0.0824046278463658 no 3103 0.0821115085476584 4417 2253075 SGTC_2932 9016711 44.54 µM -1.4001672277578 0.0810523379008733 no 3104 0.0807316235763021 4427 7117328 SGTC_48 0382-0018 55 µM -1.40962828818965 0.0796731479215395 no 3105 0.0793247348116742 4476 762596 SGTC_951 1171-0579 82.7 µM -1.41110390190695 0.0794596498014743 no 3106 0.0791069898325963 4382 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_902 1120-0002 2.07 µM -1.41258286377548 0.0792461019867566 no 3107 0.0788892052613418 4432 3280475 SGTC_919 tnp00227 403.569 nM -1.41341309409563 0.079126415313031 no 3108 0.0787671488888479 4395 1269246 A methoxyflavone. YNL221C POP1 SGTC_3145 9085516 49.47 µM -1.41690350101347 0.0786247324971183 no 3109 0.0782555713955456 4422 25236195 SGTC_2487 5918373 44.05 µM -1.41723958333229 0.0785765542731237 no 3110 0.0782064462162404 4502 2876279 SGTC_3312 9133330 71.43 µM -1.41800304701151 0.0784671930401716 no 3111 0.0780949375907221 4460 17617324 SGTC_246 cycloheximide 667 µM -1.42056766264078 0.0781006732197985 no 3112 0.0777212425073413 4356 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2 0422-0095 29 µM -1.42062928719888 0.07809188220514 no 3113 0.0777122798038076 4349 6790840 SGTC_1347 1493-0251 600 nM -1.42142365115086 0.0779786298820263 no 3114 0.0775968173831701 4484 3986378 SGTC_585 0kpi-0023 191 µM -1.42275735751515 0.0777887639376154 no 3115 0.0774032534374272 4383 64601 SGTC_656 4090-1979 187 µM -1.42730668050043 0.0771437633145817 no 3116 0.0767457579278686 4472 22330961 SGTC_985 1493-0307 8.71 µM -1.43015418245143 0.0767421188134375 no 3117 0.0763363860924218 4487 3278274 SGTC_2975 9084847 53.72 µM -1.43026152159113 0.0767270096224252 no 3118 0.0763209870154716 4453 27211724 SGTC_1752 st044819 83.042 µM -1.43614124177772 0.0759028239019973 no 3119 0.0754810773563834 4401 441209 YML126C ERG13 SGTC_1045 1348-1485 165 µM -1.43621593311115 0.0758923976329136 no 3120 0.0754704532982285 4427 6810614 SGTC_162 k030-0015 37.8 µM -1.43736428177171 0.0757322352705636 no 3121 0.0753072561675232 4510 1809920 YMR134W ERG29 SGTC_3141 9094609 49.47 µM -1.44285962736365 0.0749693511914256 no 3122 0.0745300090392694 4432 25236309 YDL196W YDL196W SGTC_2135 5326629 150.42 µM -1.44479170887386 0.0747025297862238 no 3123 0.0742582003259671 4410 5020077 SGTC_2739 tacrine 100.86 µM -1.44772140241563 0.0742993210312604 no 3124 0.0738474909096766 4528 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2516 gossypol 71.55 µM -1.45882621359559 0.072786062085033 no 3125 0.0723064728835189 4485 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1061 3448-9325 110 µM -1.45939276999722 0.0727094945242242 no 3126 0.0722285174058617 4427 723482 SGTC_3235 9132602 49.47 µM -1.46337633416333 0.0721728740539233 no 3127 0.0716822153548213 4458 4912240 SGTC_1443 4112-3303 14 µM -1.46941058224636 0.0713657975750236 no 3128 0.07086072938554 4523 704433 SGTC_3095 9117207 49.47 µM -1.46974803917338 0.0713208683116485 no 3129 0.070815003357571 4474 17015229 SGTC_2720 fluspirilene 36.88 µM -1.47096872832987 0.0711585261719784 no 3130 0.0706497870597666 4465 3396 An atypical antipsychotic. SGTC_2742 clothiapine 36.27 µM -1.47277022774275 0.0709194593534718 no 3131 0.0704065013899997 4518 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2546 rhodinyl acetate 100 µM -1.47327520114519 0.0708525580154321 no 3132 0.0703384223570161 4429 6708682 SGTC_1555 citronellol 128 µM -1.47389064161652 0.0707710870287766 no 3133 0.0702555189302698 4446 8842 A terpine precursor. SGTC_1104 tacrolimus 29.8 µM -1.47800691187485 0.0702280315312757 no 3134 0.0697029641058511 4547 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_281 1672-3440 14.9 µM -1.48216711655008 0.0696824419138444 no 3135 0.0691479169401266 4521 6833000 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.49108692288251 0.0685236589302991 no 3136 0.0679693375987823 4443 1241132 A phosphatase inhibitor. SGTC_279 1273-0055 2.93 µM -1.5043620168942 0.0668266720241716 no 3137 0.0662440893538461 4535 2847562 SGTC_1994 st072947 40.9 µM -1.51116275275648 0.0659700065872591 no 3138 0.06537349484965 4548 5286565 YDL195W SEC31 SGTC_2164 5685496 200 µM -1.5159767990255 0.0653687590993252 no 3139 0.0647626095538014 4432 759046 SGTC_2067 5224629 34.075 µM -1.52071796243951 0.0647807774004798 no 3140 0.0641653145496208 4472 2835000 SGTC_1455 4262-0120 131 µM -1.52197246329785 0.0646258879334507 no 3141 0.0640079902976623 4546 1529587 SGTC_2186 6124449 200 µM -1.52305116653074 0.0644929338121333 no 3142 0.0638729524211528 4521 3834182 YLR033W RSC58 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.52414009162567 0.0643589354356317 no 3143 0.0637368597514156 4515 616764 SGTC_2950 9072895 21.46 µM -1.52523786382198 0.0642240674637645 no 3144 0.0635998898200065 4445 17332245 SGTC_2159 5658611 73.75 µM -1.52650198024134 0.0640690353329431 no 3145 0.0634424488302032 4495 793844 SGTC_1366 1683-0113 21.9 µM -1.52795338211284 0.0638913933669704 no 3146 0.063262056414541 4509 708623 SGTC_2539 epi(13)torulosol 80 µM -1.53458357403238 0.0630847694148907 no 3147 0.0624430750056058 4479 6708597 SGTC_3062 9077494 49.47 µM -1.53757382895727 0.0627235824697254 no 3148 0.06207642526516 4454 16459633 SGTC_506 n9-isopropylolomoucine 153 µM -1.54737437639937 0.0615510829439227 no 3149 0.0608864981548436 4519 6610355 SGTC_1878 temozolomide 1 mM -1.54797527905518 0.0614797539792262 no 3150 0.0608141242537235 4484 5394 DNA alkylating agent. SGTC_1958 st076513 41.9 µM -1.55042620211922 0.0611894904905775 no 3151 0.0605196268040189 4452 732122 YGL099W LSG1 SGTC_1079 idarubicin 2.36 µM -1.55061384162399 0.0611673124999447 no 3152 0.0604971265208603 4551 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1310 1188-0297 994 nM -1.55624110101829 0.0605051150678627 no 3153 0.0598253856256917 4408 1588352 SGTC_2411 st077133 39.94 µM -1.56076663642843 0.0599766451400323 no 3154 0.0592894110623018 4494 1403142 YNL221C POP1 SGTC_1511 0906-3109 28.5 µM -1.56242522745074 0.0597838706555006 no 3155 0.0590939239523402 4535 2882180 SGTC_873 0591-4978 488 µM -1.5673089338379 0.059219066061313 no 3156 0.0585212490857153 4548 3305145 SGTC_1495 4469-0029 237 µM -1.57328833274056 0.0585332515287672 no 3157 0.0578260348328506 4534 793680 SGTC_667 1498-1044 59 µM -1.57455600812541 0.0583886582799326 no 3158 0.0576794819757076 4518 6739982 SGTC_2941 9056145 11.23 µM -1.57504701632656 0.0583327284621912 no 3159 0.0576227962509657 4486 2119517 SGTC_2081 5214970 32.255 µM -1.58027496534251 0.0577398286928348 no 3160 0.0570219552247606 4475 2063512 SGTC_3223 9129970 49.47 µM -1.58196112170389 0.0575496162018809 no 3161 0.0568292230776809 4556 17248386 SGTC_3294 9122953 26.2835 µM -1.5842802140432 0.0572888087723078 no 3162 0.0565649831691645 4524 16459826 SGTC_1419 3993-2473 62.6 µM -1.59055842998834 0.0565874204417681 no 3163 0.0558544930468854 4609 704026 SGTC_3158 9100007 49.47 µM -1.5917357656169 0.056456647644777 no 3164 0.0557220442364542 4549 19297233 SGTC_462 ag-879 158 µM -1.60210670752537 0.0553149583916378 no 3165 0.0545660075052566 4560 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_811 0416-0114 265 µM -1.60524417420316 0.0549731850486211 no 3166 0.0542200397373408 4559 6612453 SGTC_1779 st039427 55 µM -1.60819362169072 0.0546534169461529 no 3167 0.0538963898389685 4540 1124498 SGTC_3193 9111931 49.47 µM -1.60949377921767 0.0545129265632549 no 3168 0.0537542070802782 4542 17087244 SGTC_258 haloperidol 50.781 µM -1.61081078948549 0.0543709064819827 no 3169 0.053610484359873 4534 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1204 4049-0315 18.3 µM -1.61872579450601 0.0535235459471103 no 3170 0.052753137176816 4565 588402 SGTC_1676 st018489 23.4 µM -1.62048083112376 0.0533370808041872 no 3171 0.0525645143812499 4520 3696235 SGTC_79 0052-0007 94.094 µM -1.62661613641155 0.0526892739079149 no 3172 0.0519093250097978 4535 2801472 SGTC_3241 9133421 49.47 µM -1.63484718123237 0.0518300090270173 no 3173 0.0510405436293675 4642 17018221 SGTC_2214 7179297 48.276 µM -1.63998337081632 0.0512994935839268 no 3174 0.050504312285827 4624 769744 SGTC_394 menadione 8.33 µM -1.64108845913325 0.0511859160031741 no 3175 0.0503895270297468 4563 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3203 9113543 49.47 µM -1.64334000218513 0.050955128490508 no 3176 0.0501563030923971 4566 17018012 SGTC_1641 st009299 47.1 µM -1.64893589620478 0.0503851254572752 no 3177 0.0495803840953147 4506 4046054 SGTC_948 3448-0295 75.3 µM -1.6504734146871 0.0502294054291399 no 3178 0.0494230732220748 4536 678569 SGTC_2655 perillic acid 100 µM -1.65783722879769 0.0494889088507929 no 3179 0.0486751623810021 4616 5702197 An apoptosis inducer. SGTC_2362 9071156 126 µM -1.65928233788536 0.0493446182438896 no 3180 0.0485294563023622 4572 653133 SGTC_164 4100-3994 89.624 µM -1.6709875208376 0.048188226728081 no 3181 0.0473620713648254 4546 4615967 SGTC_1360 1598-0022 39.8 µM -1.67144776075598 0.0481432050485269 no 3182 0.0473166344354679 4585 761525 SGTC_1548 st061468 90.8 µM -1.67443450274559 0.0478518527653552 no 3183 0.0470226183268839 4628 390799 SGTC_3256 9138902 49.47 µM -1.67731737153301 0.047571973660592 no 3184 0.0467402186959222 4680 17228773 SGTC_2585 alliin 100 µM -1.67877715528896 0.0474307536086846 no 3185 0.0465977412218865 4592 87310 A garlic compound which reacts with lipids. SGTC_113 0099-0221 2.5 µM -1.67880562154874 0.0474280031140669 no 3186 0.046594966332953 4540 89219 SGTC_2810 7959871 45.46 µM -1.67962541556116 0.047348847001457 no 3187 0.0465151097555534 4523 2974535 SGTC_603 3794-0023 45.9 µM -1.68039012533663 0.0472751050763753 no 3188 0.0464407180210564 4620 3802260 SGTC_1780 st038448 24.544 µM -1.68074818832725 0.0472406082658475 no 3189 0.0464059181370558 4601 728868 YDL195W SEC31 SGTC_2642 cholecalciferol 100 µM -1.68833841825989 0.0465140794821913 no 3190 0.045673142202911 4591 9821465 A vitamin D precursor, similar to steriods. SGTC_356 1634-0012 32.5 µM -1.68914643779332 0.0464372677414107 no 3191 0.0455956852561508 4584 735457 SGTC_1269 0831-0796 3.05 µM -1.691722072901 0.0461931027534056 no 3192 0.0453494888981306 4616 927758 SGTC_3343 9148379 18.9835 µM -1.69242048253953 0.0461270729257688 no 3193 0.045282914858547 4598 1955036 SGTC_2873 9040596 71.43 µM -1.69540335727533 0.0458459154852734 no 3194 0.0449994647412591 4547 6463863 SGTC_278 4092-0821 23.9 µM -1.69608296346196 0.0457820507222176 no 3195 0.044935084771058 4567 877900 SGTC_2458 5808907 16.39 µM -1.6962051756592 0.0457705736406106 no 3196 0.0449235153214307 4679 2731747 SGTC_1394 3474-0001 65.7 µM -1.69736108968946 0.0456621348190245 no 3197 0.0448142070848477 4581 5017666 YIL048W NEO1 SGTC_3133 9127736 49.47 µM -1.69803314036144 0.045599183280982 no 3198 0.0447507535757567 4585 27243420 SGTC_2813 7971799 71.43 µM -1.70423289187866 0.0450217327439828 no 3199 0.044168793281219 4575 2234054 SGTC_325 2810-4341 181 µM -1.71207657843216 0.0442996139709604 no 3200 0.043441278504956 4596 774970 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.71432238300486 0.04409458479003 no 3201 0.0432347672811842 4613 23665772 A membrane-active detergent. SGTC_110 0850-0284 111.64 µM -1.72506087417157 0.0431247738329769 no 3202 0.0422582513218983 4551 3906265 SGTC_71 0417-1750 47.813 µM -1.72717385105558 0.0429359911198748 no 3203 0.0420682227692551 4554 6811472 SGTC_1681 tripelennamine 100 µM -1.7331425552788 0.04240632595982 no 3204 0.0415351671038375 4513 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1895 st058434 18.3 µM -1.73492890607739 0.0422488361132266 no 3205 0.0413766992220956 4596 5393175 SGTC_924 2046-0044 21.3 µM -1.73803303033148 0.0419762934622503 no 3206 0.0411024969343951 4569 3623589 SGTC_2091 4-phenylthiadiazole 200 µM -1.73959741324807 0.0418394807338069 no 3207 0.0409648668954328 4616 270010 SGTC_1870 st057514 26.5 µM -1.74613779745111 0.0412713985850863 no 3208 0.0403935051475666 4606 5393161 SGTC_1236 0330-0013 258 µM -1.74879784696605 0.0410421489191193 no 3209 0.040162984555795 4628 4617066 SGTC_621 3584-0052 32.1 µM -1.74961792066559 0.0409716815657258 no 3210 0.0400921326667894 4626 2273927 SGTC_754 3474-0146 171 µM -1.75064255577671 0.0408837745840706 no 3211 0.0400037500355885 4586 24762078 SGTC_861 0443-0273 110 µM -1.75646346604976 0.040387278130592 no 3212 0.039504652146046 4608 6149169 SGTC_726 3448-4391 34.2 µM -1.76767061823543 0.039445151389251 no 3213 0.0385579923419902 4670 1356692 SGTC_489 paxilline 115 µM -1.78024781589758 0.0384092247474123 no 3214 0.0375177065967995 4581 105008 A toxic potassium channel blocker. SGTC_1187 1391-0724 117 µM -1.78299937973041 0.0381855734737351 no 3215 0.0372932021474219 4655 6997986 SGTC_974 1326-0144 138 µM -1.79140229477177 0.0375091383009529 no 3216 0.0366143804760324 4627 5411856 SGTC_574 1315-0397 40 µM -1.79233840207216 0.0374343911515589 no 3217 0.0365393876855647 4610 6794277 SGTC_2152 5568786 200 µM -1.79599446894814 0.0371436227759338 no 3218 0.0362476983466604 4664 5399883 SGTC_2114 5491910 81.25 µM -1.79625338157996 0.0371231015319498 no 3219 0.0362271141923517 4630 2849228 SGTC_2816 7982706 58.44 µM -1.79800933589666 0.0369841701408734 no 3220 0.036087764164851 4598 2981853 SGTC_2431 5490079 200 µM -1.8178530622834 0.0354434797726328 no 3221 0.034543296985519 4645 5722345 SGTC_778 3456-2434 196 µM -1.82221760781581 0.0351117704604165 no 3222 0.0342109869621757 4549 5539063 SGTC_76 0433-0009 400.328 µM -1.82651381594058 0.0347877468646738 no 3223 0.0338864510454666 4675 2841569 SGTC_299 1273-0059 1.44 µM -1.82836684535618 0.0346487497106907 no 3224 0.0337472568815385 4393 2848077 SGTC_2629 bisabolol 100 µM -1.82972641896801 0.0345470574239045 no 3225 0.0336454291717915 4626 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_568 1193-0097 7.48 µM -1.83180514957759 0.0343920483314517 no 3226 0.0334902278826065 4447 3646150 SGTC_2369 9071472 200 µM -1.84181777088165 0.0336534024162395 no 3227 0.0327509048703258 4650 17296037 SGTC_716 1683-5115 658 µM -1.84423776354608 0.0334768487613209 no 3228 0.0325742485478401 4631 723597 SGTC_720 r052-1644 49.9 µM -1.84544179741888 0.0333892914178696 no 3229 0.0324866488574849 4647 1422863 YOR257W CDC31 SGTC_1703 st026983 48.3 µM -1.85180551330749 0.0329296487085937 no 3230 0.0320268778382855 4657 1104023 SGTC_1685 st024049 53.0905 µM -1.85890899018086 0.0324227467504906 no 3231 0.0315200197905758 4670 1941139 SGTC_2090 5301565 104.445 µM -1.86419344380531 0.0320498403518574 no 3232 0.0311472718684081 4657 2056344 SGTC_1375 2910-0797 186 µM -1.86508655378244 0.0319871677297781 no 3233 0.0310846364996601 4648 742508 SGTC_2648 atorvastatin 78.68 µM -1.86676439695023 0.0318697013202793 no 3234 0.0309672482003847 4661 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_512 prima-1 270 µM -1.86733693372676 0.0318296994409591 no 3235 0.0309272753941361 4646 322968 A re-activator of the apoptotic function of mutant p53. SGTC_180 1486-1293 102.781 µM -1.86996456705175 0.031646644140365 no 3236 0.0307443692379086 4581 4140536 SGTC_795 0685-0265 78 µM -1.87372167988858 0.0313864152044729 no 3237 0.0304843980838656 4652 302754 SGTC_1982 st072467 71.9 µM -1.87669060111399 0.0311820324710421 no 3238 0.0302802557841382 4640 3163533 SGTC_1927 st060202 13.8 µM -1.8817835287499 0.0308339961385174 no 3239 0.0299327065458541 4596 688887 SGTC_112 phenothiazine 287.218 µM -1.88842253551377 0.0303851392358184 no 3240 0.0294846241731377 4620 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1558 st069300 45.6 µM -1.8895480928708 0.0303095807621881 no 3241 0.0294092124709671 4635 24208000 SGTC_1910 st062352 60.4 µM -1.89158126118696 0.0301734891934406 no 3242 0.0292733972743338 4581 2245730 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.89370294397113 0.0300320133319642 no 3243 0.0291322251754171 4675 5106787 A p450 inhibitor. SGTC_276 colchicine 750 µM -1.89700856430286 0.0298126877555184 no 3244 0.0289134038875974 4665 2833 A microtubule depolymerizer. SGTC_1798 st045719 60.953 µM -1.89803825538183 0.0297446405112561 no 3245 0.0288455213957603 4638 3980186 SGTC_2566 crystal violet carbinol 226 nM -1.8984740999963 0.0297158765162247 no 3246 0.0288168282284867 4588 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_283 0987-0079 11.7 µM -1.90449858054779 0.0293206439299846 no 3247 0.0284226406788512 4664 411556 SGTC_1897 st060201 15 µM -1.90556882526831 0.029250889826194 no 3248 0.0283530850046355 4647 611878 SGTC_481 bay k-8644 50 µM -1.90889143703676 0.0290352134368751 no 3249 0.0281380489471445 4631 2303 A calcium channel antagonist. SGTC_2824 7998404 51.95 µM -1.90937823913126 0.0290037255485184 no 3250 0.0281066579467054 4644 837851 SGTC_2328 6201408 200 µM -1.91387816467755 0.0287139976365657 no 3251 0.0278178624985968 4601 2890418 SGTC_1449 4112-4002 201 µM -1.91402897427065 0.0287043295845382 no 3252 0.0278082268424052 4687 2059539 SGTC_419 nsc-638432 893 µM -1.91796415392501 0.0284530096667914 no 3253 0.0275577782727405 4647 368090 SGTC_1853 st056710 91.2 µM -1.93739953421217 0.0272384728973012 no 3254 0.0263482617679136 4680 269167 SGTC_515 4092-1064 102 µM -1.9446308948602 0.0267977580087037 no 3255 0.0259097090808608 4631 717353 SGTC_1412 3909-8563 178 µM -1.94821798265217 0.0265813621173985 no 3256 0.0256944429961535 4733 23767530 SGTC_2404 5161160 200 µM -1.96547182367746 0.0255607977830156 no 3257 0.0246798268508076 4643 2831543 SGTC_553 k007-0256 45.7 µM -1.96594208028364 0.0255334479397781 no 3258 0.0246526507456878 4707 6287000 SGTC_1084 voriconazole 435 nM -1.98168131970091 0.0246321000601624 no 3259 0.0237574596205482 4700 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_638 3970-0837 4.09 µM -1.98387572035098 0.0245085785845261 no 3260 0.0236348481032601 4693 4118451 YLR208W SEC13 SGTC_2073 5212005 126 µM -1.98625794365201 0.0243750736468704 no 3261 0.0235023449439426 4639 691789 SGTC_2287 7945887 168.79 µM -1.98659867367803 0.0243560284030555 no 3262 0.0234834441634056 4695 1245853 SGTC_2047 4141938 200 µM -1.99638802172663 0.023814161507929 no 3263 0.0229458518061093 4700 3807862 SGTC_2666 tannic acid 100 µM -2.00130949027789 0.023545595702266 no 3264 0.0226795238236405 4669 16134267 A thiamine antagonist. SGTC_1279 0874-0590 65.2 µM -2.00197738617151 0.0235093455461565 no 3265 0.0226435818566641 4726 3523074 SGTC_53 0973-0023 39.979 µM -2.00234572246994 0.0234893741283837 no 3266 0.0226237808572026 4607 674768 SGTC_1636 st007707 68.9 µM -2.00918110163987 0.0231213381102521 no 3267 0.0222589655777377 4688 403051 SGTC_3222 9128301 49.47 µM -2.01129407468179 0.023008556846816 no 3268 0.0221472020017551 4632 4911358 SGTC_410 α-linolenic acid 100 µM -2.01232788854439 0.0229535454051927 no 3269 0.0220926922339348 4707 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3002 9075603 71.4286 µM -2.01462456588369 0.0228317306657893 no 3270 0.0219720007461853 4644 20105405 SGTC_690 glyoxal 20.3 µM -2.01780333945723 0.0226640289895539 no 3271 0.0218058734833037 4510 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2821 7996764 71.43 µM -2.02605786274544 0.0222333897219196 no 3272 0.0213794277323699 4646 2987135 SGTC_2351 9026858 72.31 µM -2.03279253373249 0.0218871747647141 no 3273 0.0210367438902094 4614 1409300 SGTC_663 1486-0733 13.9 µM -2.03689218679 0.0216786579624528 no 3274 0.0208304236389118 4704 722445 YPR165W RHO1 SGTC_1070 indatraline 8.81 µM -2.04138286602039 0.0214521813743401 no 3275 0.0206063930858502 4719 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1619 st003326 88.7 µM -2.06574585686433 0.0202580643175515 no 3276 0.0194262414373086 4679 2849032 SGTC_2506 ethyl hematommate 54.16 µM -2.07525385131937 0.0198075787670134 no 3277 0.018981507028309 4694 3940691 An allergen. SGTC_2185 6113692 200 µM -2.07807695780836 0.0196754691430197 no 3278 0.0188511357828315 4692 874150 SGTC_1399 3562-5772 25 µM -2.07820698323635 0.0196694025588947 no 3279 0.0188451495968666 4700 23847490 SGTC_787 4152-0075 138 µM -2.07873257321243 0.0196448963389178 no 3280 0.0188209686599721 4706 9566539 SGTC_3225 9130819 49.47 µM -2.09078520100423 0.019090002047786 no 3281 0.0182736616530282 4672 4547121 SGTC_2560 caryophyllene 100 µM -2.09469525310324 0.0189128733846643 no 3282 0.018099045741927 4723 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1672 st016598 6.51 µM -2.09966378747051 0.0186898132419583 no 3283 0.0178792136202758 4682 4665860 YNL267W PIK1 SGTC_442 cape 100 µM -2.10074250775555 0.0186416815406236 no 3284 0.0178317878528376 4721 5281787 SGTC_116 0155-0182 31.788 µM -2.10518334734511 0.0184446443333454 no 3285 0.0176376756268984 4602 771486 SGTC_1955 wogonin 32.4 µM -2.12158863543937 0.0177320592161073 no 3286 0.0169361487796256 4674 5281703 A flavanone. SGTC_812 4251-0442 148 µM -2.13969562577814 0.0169729603198702 no 3287 0.0161896863961779 4726 5723007 SGTC_551 k048-0028 34.9 µM -2.15296907378508 0.0164343024083058 no 3288 0.0156605545729823 4686 6836383 SGTC_360 0957-0399 1.01 µM -2.17855019142499 0.0154373789403953 no 3289 0.0146825498873168 4721 6752301 YPR165W RHO1 SGTC_1411 3909-8223 150 µM -2.19774126092124 0.0147239840160581 no 3290 0.0139837747111488 4759 X1411 SGTC_171 k064-0041 9.68 µM -2.20648769722348 0.0144083746853486 no 3291 0.0136749353534914 4695 53325 SGTC_2718 lomofungin 53.02 µM -2.21032005849775 0.0142719322654124 no 3292 0.0135414787432078 4695 5351222 A RNA synthesis inhibitor. SGTC_2255 7941087 197.44 µM -2.23595490565437 0.0133875687989675 no 3293 0.0126773625905482 4740 935561 SGTC_2291 7917025 104.35 µM -2.23759812804107 0.0133325302917814 no 3294 0.0126236368736145 4665 2964612 SGTC_1617 st002906 78 µM -2.26950531028694 0.0123019151415431 no 3295 0.0116188073323396 4728 5150859 SGTC_2961 9083290 32.55 µM -2.26986102552195 0.0122908257967079 no 3296 0.0116080082500596 4704 17741490 SGTC_280 3448-3607 3.04 µM -2.27044366417361 0.0122726808744032 no 3297 0.0115903388757339 4727 626179 SGTC_1066 ketoconazole 628 nM -2.28741172006169 0.0117543353656282 no 3298 0.0110859014248218 4752 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_753 1322-0200 289 µM -2.3009890792512 0.0113533586574291 no 3299 0.0106961241852739 4754 5403907 SGTC_941 3237-0776 460 µM -2.31611346146871 0.010920738945157 no 3300 0.0102760372481304 4728 760008 SGTC_783 0848-0141 92.7 µM -2.31763858446007 0.0108779208791373 no 3301 0.0102344856919795 4715 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2462 5162487 171.77 µM -2.32812717392959 0.0105873902240383 no 3302 0.00995267588257004 4728 2259986 SGTC_1522 st012842 45.6 µM -2.33512047268407 0.0103974550725813 no 3303 0.00976856405542361 4626 3491067 YOR116C RPO31 SGTC_1775 st081588 35.1725 µM -2.34379309087169 0.0101660412367512 no 3304 0.00954437886020239 4722 1426443 YGL099W LSG1 SGTC_1086 cerivastatin 2.18 µM -2.36284902942635 0.00967329346236793 no 3305 0.00906752780497018 4758 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_996 3970-0799 1.8 µM -2.38086735406976 0.00922670394259317 no 3306 0.00863596504193627 4696 6615648 YGL040C HEM2 SGTC_2701 st077767 14.721 µM -2.38563773361172 0.00911153267556283 no 3307 0.00852476834143719 4730 5721188 SGTC_1738 st035555 74 µM -2.39046275488013 0.00899632458435494 no 3308 0.00841357789488213 4726 5331140 SGTC_1141 3253-0389 52.6 µM -2.40830500965993 0.00858131088980536 no 3309 0.00801339253310897 4746 5402031 SGTC_2882 9058044 58.44 µM -2.41169165492714 0.00850446195710885 no 3310 0.00793935198449232 4736 18076804 SGTC_1814 st052110 31.539 µM -2.41350754608373 0.00846350543921991 no 3311 0.00789990035567799 4729 674163 SGTC_3074 9116018 49.47 µM -2.41404737868679 0.00845136321199851 no 3312 0.00788820537434826 4753 17027303 SGTC_503 tyrphostin 8 294 µM -2.43064715233315 0.00808537975191332 no 3313 0.00753594219846638 4757 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -2.43793180578277 0.00792921894801869 no 3314 0.00738578017445446 4736 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_268 camptothecin 39.6153 µM -2.4560478312664 0.00755231275187303 no 3315 0.00702372294359516 4720 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1376 2910-0861 41.3 µM -2.46458796250907 0.00738017255022334 no 3316 0.00685854449426453 4725 1112859 SGTC_2461 5755302 26.15 µM -2.47950320539752 0.00708781274156294 no 3317 0.00657827737700938 4749 2788904 SGTC_3337 9144342 33.5465 µM -2.51427865391055 0.00644551986869297 no 3318 0.00596380747331234 4756 17682949 SGTC_477 mead ethanolamide 10 µM -2.52302147416364 0.00629237355468604 no 3319 0.00581756478172381 4786 16061185 SGTC_1795 st049545 62.3 µM -2.5506069096544 0.00583007135375944 no 3320 0.00537677684848781 4758 5291882 SGTC_3200 9114385 49.47 µM -2.6028491999888 0.00503642053781688 no 3321 0.00462263047215051 4733 17018030 YLR208W SEC13 SGTC_2689 tacrolimus 100 µM -2.63200165410205 0.0046366986701694 no 3322 0.00424417248057809 4754 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_458 nppb 133 µM -2.65318473484911 0.00436426324697544 no 3323 0.00398681090670776 4784 4549 A chloride channel blocker. SGTC_2507 purpurin 79.67 µM -2.65734998720391 0.00431240851601395 no 3324 0.00393788164563466 4757 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1718 roemerine 11.9335 µM -2.67179769995428 0.00413678539659883 no 3325 0.00377230585673517 4509 235224 An aporphine alkaloid with mutagenic activity. SGTC_1602 st001878 87.6 µM -2.68327905427984 0.004001813814671 no 3326 0.00364520650138893 4766 595405 YLR310C CDC25 SGTC_2162 5663267 200 µM -2.70535118488063 0.00375336855319751 no 3327 0.00341161063154641 4772 6456493 SGTC_647 0140-0236 81 µM -2.71694569918636 0.00362848055926917 no 3328 0.00329437082568095 4786 990837 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.73770517792518 0.00341415760529365 no 3329 0.00309347564658825 4776 688669 SGTC_2157 5649910 96.377 µM -2.79923402383409 0.00284412653187619 no 3330 0.00256119988354934 4768 2858091 SGTC_511 blebbistatin 171 µM -2.81424929836376 0.00271874754380988 no 3331 0.00244456481783742 4790 3476986 A myosin inhibitor. SGTC_1294 1000-1494 117 µM -2.81501857935623 0.00271246043691991 no 3332 0.00243872069896162 4789 712797 YDL207W GLE1 SGTC_2947 9072639 7.68 µM -2.8166117721521 0.00269948146476111 no 3333 0.00242665761379043 4746 16488146 SGTC_747 3448-8087 38.7 µM -2.83121766627037 0.00258308223554873 no 3334 0.00231855761399556 4794 5168703 SGTC_3198 9112019 49.47 µM -2.87051076181831 0.00229211482411962 no 3335 0.0020490462340671 4781 45595555 SGTC_41 0478-0632 82.643 µM -2.8908854264241 0.00215323185450398 no 3336 0.00192079072696966 4771 3750424 SGTC_3000 9075062 71.4286 µM -2.89644677628358 0.00211667239460293 no 3337 0.00188707328214936 4784 17057871 SGTC_2099 5377090 177.372 µM -2.97041152869253 0.00168117191982836 no 3338 0.00148700527067984 4794 2243829 SGTC_1453 4237-0541 195 µM -3.02389263761102 0.0014189451095862 no 3339 0.00124772489676277 4788 739892 SGTC_808 0711-0032 135 µM -3.03131605549208 0.00138565807328327 no 3340 0.00121745114559075 4787 4252555 SGTC_1036 k216-0215 33.5 µM -3.08542106577941 0.0011637887722725 no 3341 0.00101632084432884 4785 622330 SGTC_507 nimesulide 162 µM -3.08668601581281 0.00115901459568759 no 3342 0.00101200632161348 4793 4495 A COX2 inhibitor. SGTC_1606 st000094 49.2 µM -3.19021250654049 0.000823915687973585 yes 3343 0.000710841063241199 4796 1242210 SGTC_2120 5538279 151.968 µM -3.27836953482123 0.00061151524701934 yes 3344 0.000522043076510758 4805 2058197 SGTC_284 0988-0104 32.6 µM -3.31366585860047 0.000541654395122556 yes 3345 0.000460407381321573 4785 4666532 SGTC_1056 3448-1962 115 µM -3.31600167754092 0.000537302220283809 yes 3346 0.000456576403352324 4796 715507 SGTC_2280 7785178 200 µM -3.35236013650036 0.000473596896861943 yes 3347 0.000400628575617006 4793 2954328 SGTC_1859 st055998 20 µM -3.37720841640924 0.000434164785479653 yes 3348 0.0003661277179284 4785 676301 SGTC_2031 5180455 200 µM -3.44731418271893 0.000338719319542073 yes 3349 0.000283094867122277 4802 29949 SGTC_457 grayanotoxin iii 135 µM -3.78385722667217 9.67214764959334e-05 yes 3350 7.72082127620048e-05 4760 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1353 1498-1206 8.11 µM -3.83553393292845 7.90690158195445e-05 yes 3351 6.26459027637414e-05 4805 6756808 SGTC_2885 9057732 51.95 µM -3.84165939183029 7.71903406956586e-05 yes 3352 6.11026695166593e-05 4799 6471414 SGTC_73 0327-0325 16.231 µM -3.90554767699404 5.99457156140158e-05 yes 3353 4.70061099009505e-05 4768 53298 SGTC_1715 st032160 10.2275 µM -4.19492314299445 1.82066913696679e-05 yes 3354 1.36482064096453e-05 4785 5289825 SGTC_1629 st005085 44.9 µM -4.2170225724049 1.65708957097175e-05 yes 3355 1.23774601942226e-05 4804 24207091 SGTC_569 4130-2812 160 µM -4.29133202622609 1.20350877944581e-05 yes 3356 8.88022619231758e-06 4808 743552