SGTCid condition conc unit PHO91|YNR013C.score PHO91|YNR013C.strain.pval PHO91|YNR013C.strain.significant PHO91|YNR013C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1486 3970-0793 4.53 µM 5.71998634044824 1.64010178696813e-08 yes 1 5.32663086589297e-09 2 2844330
SGTC_1527 coumarin 137 µM 5.12967813409064 3.65999859962702e-07 yes 2 1.4511900350668e-07 3 323 A hepatotoxic, DNA x-linker.
SGTC_1477 0139-0234 16 µM 4.51553400356483 6.6101301839173e-06 yes 3 3.15787054665248e-06 5 620880
SGTC_1502 4534-4282 27.7 µM 4.27289234164877 1.88733618565924e-05 yes 4 9.6476815863033e-06 6 3278949
SGTC_2575 plumbagin 510 nM 4.22860559194474 2.2726080883738e-05 yes 5 1.17572075255508e-05 32 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1777 st045864 34.765 µM 4.1682528830382 2.9189899466902e-05 yes 6 1.53471645529687e-05 8 4691462
SGTC_1753 st043925 64 µM 4.16563535876841 2.95063257340651e-05 yes 7 1.55243317634475e-05 6 670181
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 4.12650702261196 3.46412630897312e-05 yes 8 1.84157381001284e-05 17 5024745
SGTC_3000 9075062 71.4286 µM 4.11648102969228 3.60870658126039e-05 yes 9 1.9235048893042e-05 15 17057871
SGTC_573 3702-0553 84.7 µM 4.05360813366692 4.65390349867025e-05 yes 10 2.52168356428677e-05 12 1222756
SGTC_1448 4255-0083 152 µM 4.05028573714268 4.7164134801691e-05 yes 11 2.5577565189617e-05 17 5399660
SGTC_1268 0828-0275 2.46 µM 3.81620330863854 0.00011777721793291 yes 12 6.776042657414e-05 23 745337
SGTC_2419 paclitaxel 166.5 µM 3.69718850676926 0.000184070731808492 yes 13 0.000109000232037543 54 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2359 9039622 200 µM 3.66807106335089 0.000204924785151829 yes 14 0.000122193633327386 29 6463596
SGTC_1159 4092-0538 61.2 µM 3.5730961031909 0.000289301084720708 yes 15 0.000176392606615564 44 717301
SGTC_1452 4194-0072 190 µM 3.51334791796012 0.000357913558773778 yes 16 0.000221248823379535 24 1343545
SGTC_932 2857-0803 154 µM 3.45257728077361 0.000442974259265059 yes 17 0.000277629198885656 43 674898
SGTC_2367 9070478 135.38 µM 3.36203230577729 0.000604945579829083 yes 18 0.000386855355142847 64 572802
SGTC_2966 9084041 48.03 µM 3.31774094149892 0.00070270598614035 yes 19 0.00045374304593352 61 17741380
SGTC_2427 5545055 42.75 µM 3.27057122971066 0.000822684083176802 yes 20 0.000536652542220712 40 5372858
SGTC_401 neomycin 50 µM 3.24342697075132 0.000900001175836325 yes 21 0.000590505411574881 23 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1439 4092-1168 46 µM 3.23654781581393 0.000920628987023007 yes 22 0.000604924777138534 25 2886240
SGTC_804 1595-0054 20.9 µM 3.19419126649095 0.00105750733489494 no 23 0.000701115901060772 73 761523 Stimulates phospholipase C.
SGTC_847 0342-0274 5.54 µM 3.17337623674538 0.00113139874762374 no 24 0.000753385634660461 46 18097
SGTC_2750 bromebric acid 70.15 µM 3.16222065594507 0.00117291904329736 no 25 0.000782854373126016 73 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3145 9085516 49.47 µM 3.1592557861817 0.00118418636513329 no 26 0.000790863006202585 66 25236195
SGTC_3025 9087895 49.47 µM 3.15770387301032 0.00119012349270909 no 27 0.000795085005164164 61 17173641
SGTC_1549 4'-methoxyflavonol 74.6 µM 3.15238011240515 0.00121069820103796 no 28 0.000809726538902532 24 97141
SGTC_521 r062-0005 13.8 µM 3.03928828789106 0.00173227742329675 no 29 0.00118568905647502 51 2832033
SGTC_1233 0325-0408 14.2 µM 3.01687293565088 0.00185728088323367 no 30 0.00127698421500886 56 12874
SGTC_587 k089-0003 57 µM 3.01679617486701 0.00185772269312776 no 31 0.00127730760702639 20 9659696
SGTC_1460 k062-0059 9.15 µM 2.98657007565694 0.00203930804969165 no 32 0.00141063085390005 54 1373085
SGTC_2552 juarezic acid 87.02 µM 2.95784200794083 0.00222667445512979 no 33 0.00154900432591842 86 1549512
SGTC_1787 fluconazole 80 µM 2.95524338441157 0.00224436959035386 no 34 0.00156211240101323 95 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.94203498744794 0.00233629628045749 no 35 0.00163031542570284 77 688761
SGTC_87 0100-0052 35.5 µM 2.90630467986828 0.00260229922390587 no 36 0.0018286257332737 238 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_798 1287-0182 476 µM 2.86963826051428 0.00290343574552237 no 37 0.00205470814805357 78 1649755
SGTC_2942 9052777 62.25 µM 2.85725026469366 0.00301206521491582 no 38 0.00213664379792644 98 6469503
SGTC_2975 9084847 53.72 µM 2.85020255627074 0.00307548745935644 no 39 0.00218456973468074 96 27211724
SGTC_903 1134-0042 114 µM 2.83796759195298 0.00318845125883223 no 40 0.00227008960804727 76 701009
SGTC_132 0417-1715 25.805 µM 2.80677368899494 0.0034935408971485 no 41 0.00250201918504629 64 6769098
SGTC_1756 st041558 35.5 µM 2.79322771600258 0.00363400486283757 no 42 0.00260924707479667 43 3955792
SGTC_2168 5727979 200 µM 2.7807143868164 0.0037682421014843 no 43 0.00271197166101842 73 695210
SGTC_1431 4049-0260 9.09 µM 2.76262791728086 0.00397012565187099 no 44 0.00286690445755678 54 3854841
SGTC_1768 st044301 37.178 µM 2.74068992070883 0.00422796592478121 no 45 0.00306551687096398 86 3931349
SGTC_231 b-estradiol 524 µM 2.72211848602572 0.00445783500564752 no 46 0.00324324406467077 44 450 A steroid.
SGTC_1548 st061468 90.8 µM 2.72005340345123 0.00448407318562518 no 47 0.00326356870049591 50 390799
SGTC_555 4296-0685 37 µM 2.69796182653557 0.00477351045768421 no 48 0.00348827201012388 59 2908540 YHR072W ERG7
SGTC_583 1488-1091 88.9 µM 2.69709287354704 0.00478522827574624 no 49 0.00349738794336056 92 4303273
SGTC_2566 crystal violet carbinol 226 nM 2.68276921652123 0.00498211314953234 no 50 0.00365076787334825 115 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3208 9114115 49.47 µM 2.65349676241467 0.00540705681200583 no 51 0.00398312673965745 124 650895
SGTC_1135 dihydrocapsaicin 536.708 nM 2.65123446276858 0.00544120194671104 no 52 0.00400990735184216 122 107982 A Capsaicinoid.
SGTC_1002 4049-0206 172 µM 2.64581726760697 0.00552374430671129 no 53 0.00407469128675299 133 4662749
SGTC_2677 mitomycin C 100 µM 2.63472284095979 0.0056962712617922 no 54 0.00421030049314623 61 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3115 9123671 49.47 µM 2.63128300763188 0.00575072633697057 no 55 0.00425315841448709 47 3286988
SGTC_880 0833-0487 87.2 µM 2.60937167423872 0.0061085709130067 no 56 0.00453543303000584 93 76075
SGTC_1288 0973-0013 65.5 µM 2.60422565795948 0.00619542142964206 no 57 0.00460410536154873 90 4315430
SGTC_1817 st052116 64.4 µM 2.59808202021331 0.00630053999074569 no 58 0.00468730493325344 79 4361398
SGTC_3296 9122258 64.045 µM 2.5910478350531 0.00642283228008664 no 59 0.00478420951859357 100 4730474
SGTC_1964 st076914 61 µM 2.57692100329777 0.00667479424070235 no 60 0.00498423647945336 88 24208661
SGTC_1670 st016595 4.04 µM 2.56923780352683 0.00681546502949832 no 61 0.00509612442226421 91 597879
SGTC_2857 9024691 58.44 µM 2.56810398510012 0.00683644421435547 no 62 0.00511282382641057 112 16478292
SGTC_1703 st026983 48.3 µM 2.56757141153615 0.00684631816392146 no 63 0.00512068461826969 88 1104023
SGTC_1262 0737-0114 49.6 µM 2.56548999542586 0.00688502867391506 no 64 0.00515150962639579 116 765919
SGTC_254 nsc-64875 3.808 µM 2.56115863224361 0.00696620421546322 no 65 0.00521618546190186 103 56993
SGTC_881 0833-0569 170 µM 2.55944205120697 0.00699860829122163 no 66 0.00524201666157803 124 5418700
SGTC_1546 5-methoxyflavanone 78.7 µM 2.55362482962836 0.00710941215926212 no 67 0.00533040284763501 80 147795
SGTC_1482 3346-2049 8.48 µM 2.55039910576972 0.00717151903178665 no 68 0.00537998316717737 109 3826804
SGTC_2047 4141938 200 µM 2.51507000873244 0.00788369527539861 no 69 0.00595043745781256 72 3807862
SGTC_752 1896-0090 130 µM 2.51370892204672 0.00791233536688459 no 70 0.00597344963178546 100 772567
SGTC_363 0455-0021 3.06 µM 2.50407452567788 0.00811769224487898 no 71 0.00613860853026855 182 4597466
SGTC_1449 4112-4002 201 µM 2.49822001883362 0.00824475603721391 no 72 0.00624093487645364 96 2059539
SGTC_1375 2910-0797 186 µM 2.4939679360945 0.00833813344838196 no 73 0.00631619775504897 110 742508
SGTC_2868 9035608 32.47 µM 2.48190430945472 0.00860812829749617 no 74 0.00653411818640019 109 6462614
SGTC_1696 st025591 34.7925 µM 2.47254782753833 0.00882278539887143 no 75 0.00670768807620023 141 2787147
SGTC_602 3130-1533 38.1 µM 2.4674762913112 0.00894108638043149 no 76 0.00680346159266089 132 720941
SGTC_2762 leflunomide 42.06 µM 2.46112052917304 0.00909130428648658 no 77 0.0069251913862057 138 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1981 st071826 47 µM 2.4046696637405 0.0105253917517077 no 78 0.00809354518805342 96 11838600
SGTC_645 0845-0943 5.41 µM 2.4028097180457 0.0105758215974065 no 79 0.00813482536776521 106 1885106
SGTC_1512 0259-0544 12.2 µM 2.3878544682613 0.0109890193636158 no 80 0.00847352557493042 150 18476
SGTC_2980 9014342 25.29 µM 2.38255986075002 0.0111386336712225 no 81 0.00859636824924255 145 2996599
SGTC_1126 isoteolin 1.0172 µM 2.3753008632334 0.0113466346910313 no 82 0.00876732555955376 163 133323
SGTC_1818 st052136 56.3 µM 2.36534261133726 0.0116374674907342 no 83 0.00900669899007186 183 674169
SGTC_1699 st031318 29.054 µM 2.36266178403424 0.0117168587860743 no 84 0.00907210998526316 118 5340658
SGTC_1801 st050089 28.441 µM 2.36030364466692 0.0117870820472789 no 85 0.00912999105626909 283 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1515 3460-0031 42.1 µM 2.35414177234398 0.0119723035477865 no 86 0.00928276436576589 104 2876596
SGTC_2978 9011784 42.97 µM 2.35387871597138 0.0119802667051512 no 87 0.00928933590257835 194 2994934
SGTC_2224 6650123 117.647 µM 2.3270450405107 0.0128170767901425 no 88 0.00998143408126388 68 2908370
SGTC_1153 4055-0057 267 µM 2.29666525449829 0.0138250555062363 no 89 0.0108189364985703 169 882706
SGTC_2416 tofa 880 nM 2.29433835376531 0.0139050048551925 no 90 0.0108855355721462 193 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1465 k213-0056 144 µM 2.28955891883739 0.0140704712290465 no 91 0.0110234493706753 147 24048857 YMR208W ERG12
SGTC_1028 k015-0029 4.8 µM 2.27907031786975 0.0144395492816853 no 92 0.0113314428118648 191 4588309
SGTC_1710 st031758 61.5 µM 2.27015287353116 0.014759866554566 no 93 0.0115991546084436 122 5394341
SGTC_2499 avocadenofuran 51.48 µM 2.26942648269425 0.0147862258807328 no 94 0.0116212016225811 183 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_909 3448-9333 149 µM 2.26850400357819 0.0148197592215237 no 95 0.0116492526346958 128 3344074
SGTC_579 4491-1009 110 µM 2.23596170685275 0.0160452900122709 no 96 0.0126771398158807 214 1271041
SGTC_1572 epiandrosterone 68.9 µM 2.23302883244189 0.0161598906246495 no 97 0.0127735215392056 162 441302 A steroid.
SGTC_2157 5649910 96.377 µM 2.23264381292746 0.0161749870218376 no 98 0.0127862212153069 164 2858091
SGTC_3175 9106517 49.47 µM 2.227729310421 0.0163687457759398 no 99 0.0129492856167778 129 41468073
SGTC_776 4476-4378 112 µM 2.22099012798611 0.0166376732699167 no 100 0.0131758150202721 137 2892008
SGTC_2824 7998404 51.95 µM 2.21747098782699 0.0167796012389744 no 101 0.0132954617310178 158 837851
SGTC_950 1165-0508 94.1 µM 2.21026814532647 0.0170733254727411 no 102 0.0135432790084279 169 6148369
SGTC_2214 7179297 48.276 µM 2.20089245749182 0.0174622300110002 no 103 0.0138718190115079 101 769744
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.18165322476355 0.0182840063622959 no 104 0.0145675677657104 228 551469
SGTC_928 2764-0428 58.7 µM 2.17384975165046 0.0186265927838537 no 105 0.014858210377723 220 662578
SGTC_1455 4262-0120 131 µM 2.17383940309634 0.0186270507072362 no 106 0.0148585990993336 198 1529587
SGTC_3120 9124077 49.47 µM 2.17364305087995 0.0186357411063385 no 107 0.0148659763134826 134 18774327 YGL155W CDC43
SGTC_2234 tolnaftate 200 µM 2.16858717699099 0.0188607017220111 no 108 0.0150570197838878 68 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1513 0337-0559 19 µM 2.1672119104832 0.0189222922874438 no 109 0.0151093498120038 185 775073
SGTC_2228 7354201 200 µM 2.1612364834925 0.0191918888719156 no 110 0.0153385382634292 102 753451
SGTC_2039 Aminomethylbenzodioxan 200 µM 2.15104906662549 0.0196590489464931 no 111 0.0157361635257773 128 15053
SGTC_1344 1488-0097 29.1 µM 2.14748293564645 0.019824844912823 no 112 0.0158774271387661 171 747966
SGTC_1569 carminic acid 40.6 µM 2.14053225385875 0.0201514069729861 no 113 0.0161558885405635 181 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1038 k292-0204 154 µM 2.1374311023919 0.0202985727051508 no 114 0.0162814719747848 163 4454212
SGTC_2706 st078239 82.5 µM 2.13278006270162 0.0205209959920085 no 115 0.0164713862548779 171 15434492
SGTC_371 0195-0006 7.36 µM 2.12743817624344 0.0207790015698529 no 116 0.0166918464992803 150 3928593
SGTC_2618 avocadyne 43.43 µM 2.12633561318791 0.0208325943828782 no 117 0.0167376623681385 173 3015189
SGTC_3028 9087778 49.47 µM 2.12139804022806 0.0210740350261486 no 118 0.0169441600259696 156 17217395
SGTC_1072 oxiconazole 14.9 nM 2.12131872586513 0.021077932631443 no 119 0.016947494783615 222 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2222 6885208 172.143 µM 2.11011028782814 0.021634896213512 no 120 0.0174244286782991 103 609514
SGTC_2026 5148700 152 µM 2.10807721280121 0.0217372436387371 no 121 0.0175121555760644 193 79838
SGTC_1743 st037606 46.3785 µM 2.10470547543757 0.0219078824955195 no 122 0.0176584767864461 209 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2907 7721985 69.9 µM 2.10370048551248 0.0219589619104492 no 123 0.0177022910455701 204 3267881
SGTC_457 grayanotoxin iii 135 µM 2.10122279781736 0.0220853220593644 no 124 0.0178107065260395 297 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3285 9112818 20.8695 µM 2.09480012565771 0.0224157338041881 no 125 0.0180943819754747 213 17017947 YPR165W RHO1
SGTC_1046 2001-0062 216 µM 2.09116968236249 0.0226043380022993 no 126 0.0182564280100327 197 739778
SGTC_508 roscovitine 141 µM 2.08935340189571 0.0226991960689041 no 127 0.0183379612885238 138 160355 A CDKinase inhibitor.
SGTC_777 1315-0167 517 µM 2.08833246179703 0.0227526633950806 no 128 0.0183839275813423 190 4221767
SGTC_2217 6934799 96.0675 µM 2.08068391729985 0.0231566084514959 no 129 0.0187314235525933 146 675606
SGTC_256 clotrimazole 625 nM 2.07833327869313 0.0232819599913111 no 130 0.0188393366819181 226 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1182 1222-0449 220 µM 2.07794150715268 0.0233029072581103 no 131 0.0188573734589334 167 658318
SGTC_1669 st015249 58.4 µM 2.07684062904654 0.0233618540106889 no 132 0.0189081354683132 152 722793
SGTC_540 1187-0821 17.3 µM 2.0654003084237 0.0239818900571868 no 133 0.0194425697118737 202 847520
SGTC_1121 fusaric acid 630.51 nM 2.05890094164242 0.0243402583377392 no 134 0.0197518644366136 221 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_594 1487-1584 10.8 µM 2.05431621701223 0.0245957509880464 no 135 0.019972548079349 197 5013332
SGTC_2793 7325131 81.82 µM 2.0439263081386 0.0251830863486677 no 136 0.0204804138563524 188 4176441
SGTC_178 4092-0806 87.505 µM 2.03954647860231 0.0254341737684838 no 137 0.0206977587217367 341 2169044
SGTC_476 mead acid 10 µM 2.03632692877015 0.0256200788075288 no 138 0.0208587687498742 115 5312531 An omega 9 fatty acid.
SGTC_901 1112-0062 60.1 µM 2.02971304550796 0.0260055516678938 no 139 0.0211928580378947 162 1908457
SGTC_1244 0416-0015 52.5 µM 2.02841279872399 0.0260819009746332 no 140 0.0212590674662232 230 96201
SGTC_1889 st059080 5.18 µM 2.01449471908941 0.0269109641847097 no 141 0.0219788093797064 216 176925 Isolated from Daphnopsis sellowiana.
SGTC_2152 5568786 200 µM 2.01227948458103 0.0270449279409037 no 142 0.0220952418941504 192 5399883
SGTC_2468 5987765 72.9 µM 2.00662186079198 0.0273895939148333 no 143 0.0223949709061841 190 26772094
SGTC_108 0509-0257 621.132 µM 2.00424147631913 0.0275356992988439 no 144 0.0225220997878843 275 536624
SGTC_3264 9137442 49.47 µM 1.99810019682592 0.0279156472491541 no 145 0.022852899209905 170 17015726
SGTC_1358 1509-0022 2.48 µM 1.99471734519987 0.0281267957959481 no 146 0.0230368582655262 206 3258434
SGTC_3121 9125696 49.47 µM 1.99259634096733 0.0282598601874443 no 147 0.0231528330938668 141 1235365
SGTC_1042 0350-0096 82 µM 1.99140340831521 0.0283349305613318 no 148 0.0232182774240552 230 3122515
SGTC_1064 honokiol 6.76 µM 1.98719640937135 0.0286009997540897 no 149 0.0234503178059831 229 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2731 amoxapine 43.43 µM 1.98411291357029 0.0287973306162096 no 150 0.0236216269266978 89 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2178 5812956 200 µM 1.98064799479286 0.029019282875587 no 151 0.0238153813059039 205 5403383
SGTC_873 0591-4978 488 µM 1.97871711512635 0.0291435848075054 no 152 0.0239239324433571 227 3305145
SGTC_2227 7312221 64.1025 µM 1.97210276614809 0.0295727462380601 no 153 0.0242989381322424 122 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2653 dihydrofissinolide 100 µM 1.95341149322808 0.0308139341756257 no 154 0.0253854277215263 167 6857746
SGTC_1763 st044482 94.5 µM 1.95104958385869 0.0309738015793426 no 155 0.0255255738577218 239 88505
SGTC_1326 1431-2094 10.8 µM 1.95029962213977 0.0310247065803004 no 156 0.0255702088438093 268 616278
SGTC_3306 9127676 59.7925 µM 1.95023742997408 0.0310289310920498 no 157 0.0255739132272924 232 41905287
SGTC_1722 st034304 3.6505 µM 1.95000338257406 0.0310448334378403 no 158 0.0255878579387967 259 4036148 YLR033W RSC58
SGTC_134 0269-0018 6.916 µM 1.94265770272969 0.0315473728320677 no 159 0.0260287649913088 355 4378915
SGTC_326 k292-0812 17.5 µM 1.94004463229338 0.0317277541804453 no 160 0.0261871329690173 171 3579357
SGTC_560 2332-1943 155 µM 1.92577404968883 0.0327279533089688 no 161 0.0270662965332284 196 21177716
SGTC_451 chloral hydrate 100 µM 1.91679542189285 0.0333704707277517 no 162 0.0276319634008658 330 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_107 0358-0022 2.6945 µM 1.91373283641542 0.03359199334691 no 163 0.0278271505686128 154 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_52 0329-0193 875 nM 1.90031990957065 0.0345764786501174 no 164 0.0286955750674344 258 3739292
SGTC_581 0958-0271 211 µM 1.89408971325985 0.0350417595533982 no 165 0.0291065514479048 337 4591145
SGTC_2551 apiole 73.87 µM 1.88951236978124 0.0353868669845524 no 166 0.0294116034345692 143 10659 A possible DNA adduct former.
SGTC_1563 conessine 56.1 µM 1.88644087818638 0.0356200001145341 no 167 0.0296177841807216 298 441082 An anti-amoebic, histamine inhibitor.
SGTC_362 0310-0100 9.03 µM 1.88629602839222 0.0356310255527948 no 168 0.0296275370916907 275 790235
SGTC_3325 9138760 55.175 µM 1.87821880952498 0.0362502750334952 no 169 0.0301756190180329 252 43844959
SGTC_572 0960-0087 17.7 µM 1.87799352605037 0.0362676721595078 no 170 0.0301910253652242 322 6796365
SGTC_2715 st079500 56.4 µM 1.86839442666807 0.0370153193626884 no 171 0.0308535566778597 214 28246688
SGTC_1602 st001878 87.6 µM 1.86399374296827 0.0373622637448964 no 172 0.0311612915117265 245 595405 YLR310C CDC25
SGTC_2404 5161160 200 µM 1.85685257839817 0.0379309133041726 no 173 0.031666065446467 307 2831543
SGTC_2892 9047358 58.44 µM 1.85118905268551 0.0383869029356931 no 174 0.0320711800613492 194 6466771
SGTC_1015 4130-4525 82 µM 1.84489186285352 0.038899147308897 no 175 0.0325266353008442 270 1363237
SGTC_1963 st076565 50.3 µM 1.8365684212095 0.0395847442475173 no 176 0.033136816365509 237 4914280
SGTC_3130 9127414 49.47 µM 1.83455582327968 0.0397519877744869 no 177 0.0332857646829927 237 1494646
SGTC_2386 9075165 157.42 µM 1.83130808985377 0.0400230801139976 no 178 0.033527285423094 215 16452277
SGTC_1146 3579-1023 7 µM 1.8283367262726 0.0402724176593618 no 179 0.0337495155722574 304 X1146
SGTC_3331 9141060 1.957 µM 1.82122587890551 0.0408742381743354 no 180 0.0342862640869454 267 4906567 YPR165W RHO1
SGTC_2062 5245942 200 µM 1.82027103743428 0.0409556031489409 no 181 0.0343588698579258 298 1376160
SGTC_201 4262-0159 12.803 µM 1.80955852532249 0.0418774839720869 no 182 0.0351821382789054 222 1341029
SGTC_2598 perillyl alcohol 100 µM 1.80728229255703 0.0420755168489014 no 183 0.0353591377649298 307 10819 An apoptosis inducer.
SGTC_1492 4158-0558 28.5 µM 1.80227529864966 0.0425137943734065 no 184 0.035751051428535 261 3967268
SGTC_1951 sophoraflavanone G 9.2 µM 1.79127906402969 0.0434892889514718 no 185 0.0366242620252534 306 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2911 7942208 15.64 µM 1.78738753341054 0.0438388114635597 no 186 0.0369374375651588 253 1243384
SGTC_1232 0279-0259 161 µM 1.78222459316868 0.0443060207761025 no 187 0.0373563069174445 293 1560000
SGTC_413 propylparaben 100 µM 1.77930166957109 0.044572298493504 no 188 0.037595158699564 258 7175 A pharmaceutical preservative.
SGTC_78 0336-0123 156.75 µM 1.77548719074577 0.0449217339678861 no 189 0.0379087393603061 256 6765896
SGTC_1978 st071761 42 µM 1.77397623093288 0.0450607578121904 no 190 0.0380335410149368 271 5147680
SGTC_1613 st002381 52.1 µM 1.77227874024551 0.0452173572180216 no 191 0.0381741492512574 296 551167
SGTC_1173 0443-0020 122 µM 1.76709524776651 0.0456982639067674 no 192 0.0386061391290004 320 5331295
SGTC_1927 st060202 13.8 µM 1.76291037119004 0.0460895146625127 no 193 0.0389578037858783 271 688887
SGTC_1075 aripiprazole 15.2 µM 1.75746943874526 0.0466022142975749 no 194 0.0394189132825359 363 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1476 4112-3294 3.34 µM 1.75645226168558 0.0466985688836147 no 195 0.0395056079453841 286 704369
SGTC_1870 st057514 26.5 µM 1.75328404013639 0.0469997110531804 no 196 0.0397766318177583 299 5393161
SGTC_2591 skatole 100 µM 1.75228617376302 0.0470948809179496 no 197 0.0398623061359915 303 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_703 3875-0075 71.8 µM 1.74636980389794 0.0476623227629532 no 198 0.0403733567358444 259 2850814
SGTC_1938 st074717 56.4 µM 1.74571880220244 0.0477250936420155 no 199 0.0404299131372688 247 17250979
SGTC_1080 nisoldipine 24.4 µM 1.7415004930336 0.0481334372099585 no 200 0.0407979434600511 316 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1325 1431-0015 227 µM 1.73523469516233 0.0487451384932595 no 201 0.0413496217350423 282 1103340
SGTC_613 3914-0030 117 µM 1.7326233271993 0.0490019018731643 no 202 0.0415813201558606 89 1145395
SGTC_1168 k815-0004 80.5 µM 1.72616644060736 0.0496414167303989 no 203 0.0421587368167009 287 642433
SGTC_27 0485-0001 32.618 µM 1.72471982500435 0.0497856043498446 no 204 0.0422889882490207 208 2054479
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.72425162387995 0.0498323425685903 no 205 0.0423312141556781 308 521171
SGTC_1937 st074714 47.2 µM 1.72117985472561 0.050139850865228 no 206 0.0426090961180052 325 17250970
SGTC_3210 9128157 49.47 µM 1.71447862894732 0.0508159461152237 no 207 0.0432204293545095 358 17590849
SGTC_1800 st050079 29.0735 µM 1.71035189457179 0.0512358961379481 no 208 0.0436004104446471 520 3645560
SGTC_1163 k060-0048 49.9 µM 1.70587566517236 0.0516945288860117 no 209 0.0440156157229207 365 6809982
SGTC_868 0527-0199 213 µM 1.69849057315358 0.0524583302166461 no 210 0.0447076051994555 332 2849450
SGTC_1282 0886-0010 32.4 µM 1.6957433974388 0.0527447319353207 no 211 0.0449672430239665 351 2836211 YNL267W PIK1
SGTC_888 0916-0002 6.97 µM 1.69320030561063 0.0530109617487388 no 212 0.0452086732272924 312 2802138 YIL048W NEO1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.69121678401128 0.0532193504201938 no 213 0.0453977032820195 307 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3316 9136639 10.545 µM 1.68518191312654 0.0538573691529336 no 214 0.0459767397689865 301 4903665
SGTC_2767 sibutramine 71.45 µM 1.68087297842725 0.0543166131747346 no 215 0.0463937947974798 328 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2417 cerulenin 830 nM 1.67776389384495 0.0546498978631385 no 216 0.0466966002747742 289 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_225 nsc-122657 1.016 µM 1.67501453554187 0.0549459662260599 no 217 0.046965689887378 201 275685
SGTC_1250 0485-0349 40.2 µM 1.66932477758266 0.0555627005174758 no 218 0.0475265161682073 360 6842794 YDL195W SEC31
SGTC_2652 actinonin 100 µM 1.66901893439715 0.0555960061469536 no 219 0.0475568137116972 262 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1840 st055363 71 µM 1.66812021849172 0.0556939654633714 no 220 0.0476459321527976 297 676033
SGTC_1013 4112-3890 241 µM 1.66723406224776 0.055790689110198 no 221 0.0477339360663309 355 705171
SGTC_2030 5175110 200 µM 1.66583875620009 0.0559432548794165 no 222 0.0478727672749203 322 2831986
SGTC_1366 1683-0113 21.9 µM 1.6576357916629 0.0568468496575782 no 223 0.0486955004336833 314 708623
SGTC_2735 sertaconazole 140 nM 1.65632508109021 0.0569922896770509 no 224 0.0488280019646087 246 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2091 4-phenylthiadiazole 200 µM 1.65301894906575 0.0573604486962552 no 225 0.0491635035668109 352 270010
SGTC_760 0568-0725 82.9 µM 1.65255917998055 0.057411794809284 no 226 0.049210305757475 321 3916171
SGTC_2016 5121758 140 µM 1.65154613108269 0.0575250577446775 no 227 0.0493135546314367 406 2795203
SGTC_129 0088-0017 176.636 µM 1.65049405747283 0.0576428697705388 no 228 0.0494209638736753 365 182446
SGTC_260 nsc-65238 3.989 µM 1.63771444281991 0.0590891395585702 no 229 0.0507406381680442 315 3246252
SGTC_750 4073-0104 132 µM 1.63223233438512 0.0597182082150379 no 230 0.0513152757949447 274 22330957
SGTC_2798 7813637 45.45 µM 1.63211552971462 0.0597316683504334 no 231 0.0513275754184464 381 956368
SGTC_325 2810-4341 181 µM 1.62942277372574 0.0600426310306485 no 232 0.0516117754805951 311 774970
SGTC_2365 9042475 200 µM 1.62936389942446 0.0600494440393698 no 233 0.0516180031665552 376 6464479
SGTC_719 2810-4230 27.3 µM 1.62386170366777 0.0606888411922907 no 234 0.0522026637384689 281 721079
SGTC_1663 st014140 55.4 µM 1.61398698869991 0.0618496986567637 no 235 0.0532651242754002 411 4207120
SGTC_802 4112-3352 742 µM 1.61304284245148 0.0619615928216531 no 236 0.0533676001512473 406 704594
SGTC_3146 9095609 49.47 µM 1.61277715996732 0.0619931082722024 no 237 0.053396464985973 340 17173999
SGTC_3273 9137859 49.47 µM 1.61134134937286 0.0621636416835407 no 238 0.0535526714979824 296 2377234
SGTC_963 1269-2853 151 µM 1.60868476535728 0.0624801329131161 no 239 0.0538426443440502 357 3668223
SGTC_343 4130-2827 29.8 µM 1.6057942256306 0.0628259220014984 no 240 0.0541595649031728 388 1118244
SGTC_3241 9133421 49.47 µM 1.60501819233865 0.0629190106493893 no 241 0.054244900559644 253 17018221
SGTC_520 3584-0023 682 µM 1.60450600618468 0.0629805084989077 no 242 0.0543012808100645 370 1340790
SGTC_1289 0976-0073 69.1 µM 1.60209093325412 0.0632711158033541 no 243 0.0545677513309301 376 3391136
SGTC_324 1315-0088 19.6 µM 1.59841340661135 0.0637156389236804 no 244 0.0549755014525983 295 6787421
SGTC_2630 antimycin a 100 µM 1.58949416978935 0.0648038479953283 no 245 0.0559744346411301 418 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3134 9127454 49.47 µM 1.58665494742288 0.0651532643921004 no 246 0.056295407656457 338 24262820
SGTC_823 0417-1665 178 µM 1.58018660481957 0.0659547662307827 no 247 0.0570320692398747 382 3429856
SGTC_509 pifithrin 175 µM 1.57375531026818 0.0667592312112915 no 248 0.0577720146812576 310 4817 A p53 inhibitor.
SGTC_1673 st016611 27.3 µM 1.57322240753101 0.0668262290420085 no 249 0.0578336642858214 409 5226799
SGTC_907 3448-6986 75.5 µM 1.57138346951113 0.0670578243529598 no 250 0.0580468016648677 429 590582
SGTC_1264 0783-0040 158 µM 1.56736564757844 0.0675659869150613 no 251 0.0585146243869966 364 2855798
SGTC_2110 5483698 200 µM 1.56219854658731 0.0682238747510461 no 252 0.0591206114550894 365 2848765 YHR062C RPP1
SGTC_3016 9080866 49.47 µM 1.56122283270697 0.0683486581060642 no 253 0.0592355917508935 401 17066299
SGTC_3196 9111891 49.47 µM 1.55859138417716 0.068686070159311 no 254 0.0595465617781625 342 18891510
SGTC_815 1582-0027 36.9 µM 1.55816609315152 0.0687407225947575 no 255 0.0595969402043593 391 3128206
SGTC_2810 7959871 45.46 µM 1.54989130467127 0.0698107680843885 no 256 0.060583803518724 463 2974535
SGTC_1444 4112-3581 28 µM 1.54798281419361 0.0700593723880915 no 257 0.0608132171340505 379 2877249
SGTC_2622 2-methoxyxanthone 59.94 µM 1.5376739951355 0.0714140137284199 no 258 0.0620641725395752 408 71034 A hepatoprotective.
SGTC_3022 9087993 49.47 µM 1.53700146896764 0.0715030814410011 no 259 0.0621464748238972 338 17173644
SGTC_3332 9141069 11.198 µM 1.53682256632265 0.0715267892158884 no 260 0.0621683828699435 350 17332883
SGTC_1959 st077091 55.8 µM 1.53648743395861 0.0715712164328151 no 261 0.0622094386958801 431 821356 YKL052C ASK1
SGTC_1838 st055369 84.5 µM 1.52216481641049 0.0734897664345093 no 262 0.0639838942505252 360 676036
SGTC_3156 9099931 49.47 µM 1.52216101365464 0.0734902809944987 no 263 0.0639843705528568 399 18111053
SGTC_2945 9067681 61.76 µM 1.52199424119895 0.0735128500844052 no 264 0.0640052618289259 358 16456930
SGTC_3263 9137018 49.47 µM 1.52186177214243 0.0735307807185181 no 265 0.0640218597611289 412 43844957
SGTC_1588 farnesol 29.9 µM 1.52150170027095 0.0735795359205818 no 266 0.0640669924808091 408 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_380 3970-0968 6 µM 1.52064749743006 0.0736952973429437 no 267 0.0641741603229169 396 2891601
SGTC_931 2812-0076 566 µM 1.51995994560833 0.073788575337059 no 268 0.0642605213927427 433 3450959
SGTC_1048 3161-0300 24.5 µM 1.51784338284945 0.0740762892536366 no 269 0.0645269427991165 449 2165101
SGTC_2049 5262831 67.185 µM 1.51051016451914 0.0750797574558919 no 270 0.0654566488610059 408 763417
SGTC_681 1642-0006 26.6 µM 1.50764195606239 0.0754750475530535 no 271 0.0658230942522386 345 4446530
SGTC_3302 9125395 16.351 µM 1.50103039436281 0.0763922777464686 no 272 0.066673850171715 392 17599668
SGTC_1036 k216-0215 33.5 µM 1.4998423398834 0.0765579932068639 no 273 0.0668276234427348 495 622330
SGTC_2606 farnesol 9.78 µM 1.49757371045866 0.0768751917537544 no 274 0.0671220206828328 436 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3061 glucosamine 200 µM 1.49576503263972 0.0771287951183245 no 275 0.0673574482751363 376 91431 and experimental redox chemotherapeutic
SGTC_3201 9113999 49.47 µM 1.49155179018481 0.0777220187105814 no 276 0.0679083423019745 428 16649224
SGTC_597 k018-0003 82.8 µM 1.49100940195581 0.0777986378086046 no 277 0.0679795132433516 448 6786234
SGTC_3080 9117754 49.47 µM 1.48937364069989 0.0780300566376818 no 278 0.0681945028729832 449 9550191
SGTC_966 1300-0360 30.2 µM 1.4883840120232 0.0781703173987653 no 279 0.0683248252540911 424 70588
SGTC_2090 5301565 104.445 µM 1.48587981167309 0.0785260935944597 no 280 0.0686554572171871 486 2056344
SGTC_2458 5808907 16.39 µM 1.4851740488056 0.0786265839580423 no 281 0.0687488622904108 420 2731747
SGTC_2818 7996756 12.99 µM 1.48398649429768 0.0787958943744862 no 282 0.0689062517994974 318 2241621
SGTC_661 1304-0007 33.6 µM 1.48351728894821 0.0788628653655854 no 283 0.0689685132310472 413 3117130
SGTC_982 1491-0518 27.5 µM 1.48126900610948 0.0791843675458546 no 284 0.0692674520752772 396 3091256
SGTC_2917 7979103 53.79 µM 1.48040342023469 0.0793084096945472 no 285 0.0693828089000298 496 2980565
SGTC_1179 1021-1431 9.29 µM 1.47586492238864 0.07996120446615 no 286 0.0699900789195731 518 2840958
SGTC_3169 9102970 49.47 µM 1.47318259058423 0.0803489232314409 no 287 0.070350904049404 389 17027839
SGTC_36 0335-0881 14.2 µM 1.4719189866564 0.0805320628839148 no 288 0.0705213778818171 526 23828853
SGTC_3077 9117319 49.47 µM 1.47060823117625 0.0807223694299868 no 289 0.0706985483203964 366 17154678
SGTC_2830 7992007 71.43 µM 1.46900406474043 0.0809557377572531 no 290 0.0709158433646393 412 1952075
SGTC_1814 st052110 31.539 µM 1.46851843920655 0.0810264851264248 no 291 0.0709817256431843 393 674163
SGTC_143 4032-1194 15.74 µM 1.46844821942935 0.0810367188122946 no 292 0.0709912558824197 534 1806963
SGTC_2202 7226349 200 µM 1.46559469826287 0.0814534108790493 no 293 0.071379368242294 361 844334
SGTC_864 0469-0573 172 µM 1.46432519440868 0.0816393116773084 no 294 0.0715525582251423 427 689425
SGTC_3046 9092212 49.47 µM 1.45778095053996 0.082602700916409 no 295 0.0724504653108115 423 25236637
SGTC_425 3825-7017 13.1 µM 1.45186398016389 0.0834810916769023 no 296 0.073269714852999 480 3397440
SGTC_155 k072-0202 43.6 µM 1.44827020039108 0.084018014236222 no 297 0.0737707491551763 406 5857737
SGTC_2719 novobiocin 32.65 µM 1.44676554595375 0.0842435830566035 no 298 0.073981299778406 336 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2732 terfenadine 20 µM 1.44513139093165 0.0844890803918111 no 299 0.0742104915870172 371 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3220 9131269 49.47 µM 1.44442880294451 0.0845947942538946 no 300 0.0743091967610491 405 17722206
SGTC_3299 9121982 43.1275 µM 1.43920883988224 0.085383317063633 no 301 0.0750456807817516 464 17594604 YPL160W CDC60
SGTC_2383 9036125 200 µM 1.4303572176277 0.0867329984925356 no 302 0.0763072602734415 397 79580
SGTC_1675 st018485 24.5 µM 1.42889084845073 0.086958119136578 no 303 0.0765178040927447 459 3323024
SGTC_3029 9088683 49.47 µM 1.42733005551052 0.0871982151995908 no 304 0.0767423906316545 443 25236615
SGTC_2264 7948757 110.76 µM 1.42458305168816 0.087621987247547 no 305 0.0771388810292582 432 2971411
SGTC_877 0771-0151 33.1 µM 1.42383336848115 0.0877379051065269 no 306 0.077247356894133 502 6166523
SGTC_528 3492-0019 172 µM 1.41835829041717 0.0885879458139386 no 307 0.078043093214216 702 2869262
SGTC_479 n-linoleoylglycine 10 µM 1.41729833568041 0.0887532169542349 no 308 0.0781978607831925 416 6433346 An anti-infammatory.
SGTC_8 0354-0001 70 µM 1.41707021311312 0.0887888164768657 no 309 0.0782312001503454 583 4993152
SGTC_1222 0366-0074 1.18 µM 1.4137555045339 0.0893072915424117 no 310 0.0787168510900115 488 286520
SGTC_2951 9072950 58.06 µM 1.41284591870108 0.089449958837598 no 311 0.0788505167246358 488 16488155
SGTC_890 0929-0006 47.2 µM 1.41137645737154 0.0896807998712009 no 312 0.0790668204860631 433 1378169
SGTC_1410 3909-8106 77.9 µM 1.41096975184858 0.0897447683590441 no 313 0.0791267666025871 450 1039210
SGTC_303 1348-1668 34.2 µM 1.41024249880668 0.0898592385600313 no 314 0.0792340454127866 440 5380509
SGTC_1494 4358-1428 177 µM 1.40676948561373 0.0904073904340733 no 315 0.0797478768393018 495 1564571
SGTC_2521 angolensin 13.4 µM 1.40674040479009 0.0904119907713186 no 316 0.0797521899556967 435 821428 A flavenoid.
SGTC_2783 7738165 71.43 µM 1.40201340132463 0.0911620746785687 no 317 0.0804556224345042 378 17201110
SGTC_1109 tnp00067 928.257 nM 1.40014898368198 0.0914591872731028 no 318 0.0807343546109285 475 676295
SGTC_1420 4'-methoxyflavone 42 µM 1.39495273652464 0.092291045308137 no 319 0.0815150462779495 464 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.39444343936274 0.0923728781424908 no 320 0.0815918691001496 479 115019
SGTC_1547 harmine 94.2 µM 1.38999813937562 0.0930894207224257 no 321 0.0822647211781226 566 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2078 5212016 200 µM 1.38255309272411 0.0942986837454739 no 322 0.0834009701777128 426 1899708
SGTC_1734 st037168 69.4 µM 1.38162395711376 0.0944504082253943 no 323 0.0835435970387962 488 708907
SGTC_2624 nerol 100 µM 1.378237777824 0.0950048824439711 no 324 0.084064943498665 466 637566 A natural product oil.
SGTC_34 0469-0683 81.75 µM 1.37492333711339 0.0955499282383487 no 325 0.0845776066654151 471 3690923
SGTC_1195 1502-0147 41.1 µM 1.3738859611564 0.0957209922738764 no 326 0.0847385443314137 529 817940
SGTC_596 1155-0152 116 µM 1.37233826373065 0.0959766273655241 no 327 0.0849790795919214 566 280313
SGTC_585 0kpi-0023 191 µM 1.36909395199253 0.09651412290597 no 328 0.0854849543047424 457 64601
SGTC_2922 7999257 32.47 µM 1.36882090282101 0.0965594605333618 no 329 0.0855276326282398 435 2988377
SGTC_3165 9101544 49.47 µM 1.36826165025067 0.0966523687785645 no 330 0.0856150951222675 512 5002184
SGTC_1659 st012954 42.1 µM 1.36804255551733 0.0966887847313388 no 331 0.0856493779845986 477 24207262
SGTC_1302 1159-0335 255 µM 1.3648790065156 0.0972157250666508 no 332 0.0861455407721489 480 649284
SGTC_1865 st057639 52.2 µM 1.36441145529761 0.0972937816906847 no 333 0.0862190522879461 498 688818
SGTC_3344 9148862 3.898 µM 1.36405875601872 0.0973526944619331 no 334 0.0862745370570318 503 4905352
SGTC_1197 1601-0112 267 µM 1.36298308638309 0.0975325294736742 no 335 0.0864439205816875 540 7350313
SGTC_1215 3852-0577 11.2 µM 1.36244117825166 0.0976232202061982 no 336 0.0865293478872841 565 2884876
SGTC_3249 9135183 49.47 µM 1.35956549490624 0.0981055134561268 no 337 0.0869837317392558 524 4902779
SGTC_1349 flufenamic acid 69 µM 1.35709687498708 0.0985209269386026 no 338 0.0873752156482447 480 3371 A non-steroidal anti-inflammatory.
SGTC_2437 5741531 144.16 µM 1.35261058670855 0.0992791630256973 no 339 0.0880900342641095 537 2262990
SGTC_420 mitomycin C 81.9 mM 1.34865011450274 0.0999520681965214 no 340 0.0887246878871249 526 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_677 0929-0063 136 µM 1.34661943930093 0.100298379634302 no 341 0.0890514150601932 431 1539583
SGTC_156 3474-0145 5.642 µM 1.34301812182807 0.100914700732692 no 342 0.0896330529953618 508 2265471
SGTC_2072 5231554 129 µM 1.3370347623771 0.101944775735073 no 343 0.0906056450135128 505 789545
SGTC_2314 7727897 200 µM 1.33563277697518 0.102187239492132 no 344 0.0908346656727231 492 900724
SGTC_628 1636-0253 16 µM 1.33436749033968 0.102406422032004 no 345 0.0910417244715778 555 4456143
SGTC_905 2-aminofluorene 215 µM 1.33316039709293 0.102615842320529 no 346 0.0912395862817076 557 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1352 1496-0991 99 µM 1.33075907549433 0.103033376237818 no 347 0.0916341488834904 510 3000039
SGTC_2478 5763493 32.33 µM 1.32985800746411 0.103190368967737 no 348 0.0917825296690608 539 1365576 YLR208W SEC13
SGTC_245 methotrexate 289.6 µM 1.3289743583124 0.103344495445189 no 349 0.0919282148348687 571 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_860 0443-0016 25.1 µM 1.32658727260323 0.103761687366728 no 350 0.0923226241470057 512 5337942
SGTC_1803 st050068 52.4 µM 1.32424916444162 0.104171502558882 no 351 0.0927101537790187 730 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1687 st020778 55.3625 µM 1.32255925104634 0.104468434148017 no 352 0.0929909964910267 689 4259299
SGTC_170 4197-0004 226 µM 1.3191455907168 0.105070111687405 no 353 0.0935602219964666 469 218692
SGTC_1071 trifluoperazine 6.31 µM 1.31665055396174 0.105511460247579 no 354 0.0939778924500187 552 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2844 9010103 25.97 µM 1.31585870166415 0.105651811367022 no 355 0.0941107361494362 539 2480525
SGTC_664 1222-0054 14.9 µM 1.31170393630068 0.106390431349678 no 356 0.0948100240600661 557 6813991
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.31062770222644 0.106582367153388 no 357 0.0949917876446537 559 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_891 0929-0073 133 µM 1.310549295102 0.106596360057873 no 358 0.0950050397330752 531 5603632
SGTC_921 1561-0023 372 µM 1.31048248235509 0.106608284821567 no 359 0.0950163332563967 548 24050882
SGTC_3122 9126309 49.47 µM 1.30981719127363 0.106727078753558 no 360 0.0951288430018253 499 17591206
SGTC_3015 9080845 49.47 µM 1.30824753758981 0.107007733575902 no 361 0.0953946814974126 558 5296973
SGTC_3147 9097027 49.47 µM 1.30131228998984 0.108254131448414 no 362 0.0965757910776836 567 25236841
SGTC_82 0054-0107 293.755 µM 1.29537604949691 0.109329259882012 no 363 0.0975952680274169 520 3104697
SGTC_1921 5740136 50 µM 1.29478323760393 0.109437045402374 no 364 0.0976975080254404 603 1774243
SGTC_172 1112-0046 2.638 µM 1.29238892604724 0.109873157602417 no 365 0.0981112448864757 488 2802135 YIL048W NEO1
SGTC_1267 0828-0272 9.49 µM 1.29098385704547 0.110129664091667 no 366 0.0983546376250665 587 745334
SGTC_105 0111-0055 734.78 µM 1.28633249592888 0.110981871080568 no 367 0.0991635230515648 458 5179370
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.284304287471 0.111354947859736 no 368 0.0995177536268971 544 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_120 rhodamine 6G 52.259 µM 1.28242688848849 0.111701083423082 no 369 0.099846468432824 660 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1437 4092-1038 11.6 µM 1.27905063365692 0.112325497995105 no 370 0.100439613036309 590 3977136
SGTC_1409 3909-8004 61.9 µM 1.27480045245076 0.113115080011202 no 371 0.101189940266189 582 2119279
SGTC_1055 3448-0672 86 µM 1.27425867278161 0.113216013617465 no 372 0.101285878834742 551 748378
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.27409056059533 0.113247345992942 no 373 0.101315661678732 649 91467 include heat shock
SGTC_1831 st055328 12 µM 1.27379023163146 0.113303336033395 no 374 0.1013688839969 579 1103068
SGTC_853 0419-0306 21 µM 1.27253507234991 0.11353754787741 no 375 0.101591535481459 534 762713
SGTC_1291 0993-0025 5.79 µM 1.27214484996616 0.113610433397183 no 376 0.101660829166265 575 4353356
SGTC_2585 alliin 100 µM 1.27182165841246 0.113670824185608 no 377 0.101718245909971 601 87310 A garlic compound which reacts with lipids.
SGTC_3054 9094397 49.47 µM 1.26703389189876 0.114568136137824 no 378 0.102571585783633 595 2598354
SGTC_2216 7189485 200 µM 1.26219179066515 0.115480747303057 no 379 0.103439890994009 564 731273
SGTC_2134 5324836 1.464 µM 1.26113918432813 0.115679818077123 no 380 0.103629352560046 501 699272
SGTC_2858 9025781 8.96 µM 1.258498837756 0.116180237339938 no 381 0.104105703633619 702 4894980 YPL153C RAD53
SGTC_1191 1487-1166 10.6 µM 1.25763412505491 0.116344457966377 no 382 0.104262053020654 664 3955771
SGTC_224 benfluorex 43.875 µM 1.25759578651716 0.116351742783539 no 383 0.104268988979986 474 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2332 7982454 138.89 µM 1.25723935918342 0.11641948406841 no 384 0.104333487506595 600 2981748
SGTC_1994 st072947 40.9 µM 1.2563684658409 0.116585120578585 no 385 0.104491204613115 588 5286565 YDL195W SEC31
SGTC_980 1473-0395 201 µM 1.2548856019891 0.116867533083881 no 386 0.104760145721436 519 768876
SGTC_2449 5812982 45.77 µM 1.25336998573926 0.11715668404453 no 387 0.105035544640346 525 776185
SGTC_2833 9001315 45.46 µM 1.25071318274382 0.117664774092663 no 388 0.105519569547726 603 2989378
SGTC_545 4218-0007 221 µM 1.24999456880547 0.117802470228298 no 389 0.105650765672936 557 2840508
SGTC_1967 st070177 51.4 µM 1.24937604866015 0.117921078317568 no 390 0.105763782255113 542 5729214
SGTC_2841 9004761 38.96 µM 1.24928457624616 0.117938626334914 no 391 0.105780503595858 518 2991039
SGTC_1819 st053448 58.6 µM 1.24796531984126 0.118191917233576 no 392 0.106021878876669 568 2857616
SGTC_1082 camptothecin 424.86 nM 1.23896421737787 0.119930353535408 no 393 0.107679374928466 523 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1685 st024049 53.0905 µM 1.23561364030971 0.120582051457745 no 394 0.108301105999487 555 1941139
SGTC_2774 tamoxifen 10.92 µM 1.23548389941207 0.120607336524462 no 395 0.108325232490582 572 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2656 pseudo-anisatin 100 µM 1.23420338376798 0.120857095126862 no 396 0.108563563431484 545 6708809 A neurotoxin.
SGTC_63 0099-0242 26.702 µM 1.23005581768217 0.121668556559388 no 397 0.109338101737388 664 3898502 YLR359W ADE13
SGTC_1376 2910-0861 41.3 µM 1.22767743116447 0.122135605775012 no 398 0.109784040928418 631 1112859
SGTC_2229 7354935 190 µM 1.22461660475111 0.122738517775445 no 399 0.110359854320833 530 318112
SGTC_1833 st055984 71 µM 1.22419973535277 0.122820792637413 no 400 0.110438444501701 586 676288
SGTC_18 0111-0177 500 nM 1.22269844536928 0.123117413116411 no 401 0.110721807195779 720 721752
SGTC_1969 st069479 40.1 µM 1.22262158222654 0.123132613010821 no 402 0.11073632882467 546 3895485
SGTC_616 4092-0450 108 µM 1.22154547882206 0.123345553484711 no 403 0.110939778616192 634 787165
SGTC_1901 st060216 58.6 µM 1.21755160406152 0.1241381208098 no 404 0.111697207480739 631 688792
SGTC_480 am 92016 50 µM 1.21732811058201 0.12418257716081 no 405 0.111739701519595 548 2129 K+ channel blocker.
SGTC_2733 amorolfine 100 µM 1.21505029144815 0.124636306294924 no 406 0.112173455378571 489 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2900 5328528 85.29 µM 1.21404149152761 0.124837623523436 no 407 0.112365940205901 651 795359
SGTC_1934 st074720 32.6 µM 1.21303618374809 0.125038469777494 no 408 0.112557993374476 653 17250992
SGTC_1643 st009866 20.2 µM 1.20984244305674 0.125678030959573 no 409 0.113169678225022 588 3156273 YOR207C RET1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.20682224986882 0.126284934806381 no 410 0.113750302690941 533 4620898
SGTC_491 tetrandrine 80.3 µM 1.20610673957467 0.126429014414356 no 411 0.113888168273942 571 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2173 5763948 167 µM 1.20400074635834 0.126853754809765 no 412 0.114294645035497 628 2867177
SGTC_2197 6588183 93.1375 µM 1.20140620717275 0.127378390467522 no 413 0.114796834750959 569 884136
SGTC_2925 9010536 32.5 µM 1.20032585724939 0.127597289882179 no 414 0.115006405659017 681 2994177
SGTC_2106 5357045 167.29 µM 1.19886502505278 0.127893697942421 no 415 0.115290216636581 630 668842
SGTC_2948 9070189 9.45 µM 1.1979598143982 0.128077608322917 no 416 0.115466330898867 554 6473636 YDL196W YDL196W
SGTC_2511 berberine 10.47 µM 1.19275273193221 0.129139091344366 no 417 0.116483113524039 626 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_962 1254-0300 21.5 µM 1.19135438172223 0.129425186138665 no 418 0.116757246707467 619 7340576
SGTC_3258 9138477 49.47 µM 1.19057020447151 0.129585816572353 no 419 0.116911177171106 631 4970355
SGTC_3206 9114350 49.47 µM 1.18396342018964 0.130944630108837 no 420 0.118213771629032 597 17087243
SGTC_743 1275-0778 158 µM 1.18327877088035 0.131086002479967 no 421 0.118349341718992 670 2849257 YMR203W TOM40
SGTC_2267 7931562 200 µM 1.18281708903942 0.131181394083575 no 422 0.118440823173236 564 934880
SGTC_714 4296-0578 26.1 µM 1.18251715892357 0.131243390616142 no 423 0.118500280580123 572 1589775
SGTC_1826 st055655 41.6 µM 1.181797834142 0.131392159843167 no 424 0.118642963706306 648 676168
SGTC_1992 st073643 23.3 µM 1.18161975286896 0.13142900820802 no 425 0.118678306116586 609 3161292
SGTC_280 3448-3607 3.04 µM 1.18059972327285 0.131640208981797 no 426 0.118880886811158 640 626179
SGTC_336 4111-0029 111 µM 1.17696326209625 0.13239505660576 no 427 0.119605084974477 577 3131175
SGTC_870 0573-2213 57.6 µM 1.17678834027538 0.132431441488345 no 428 0.119639998778363 619 3916321
SGTC_1303 1160-0052 261 µM 1.17632946314757 0.13252692367812 no 429 0.119731623261983 643 3562476
SGTC_2425 5628681 7.85 µM 1.17497329459188 0.132809389576209 no 430 0.120002700062681 733 5714958
SGTC_2095 5432005 200 µM 1.17324550082363 0.133169858612641 no 431 0.120348685148704 594 783734
SGTC_292 k038-0015 474 µM 1.17078770367331 0.133683787198749 no 432 0.120842060804541 601 46368540
SGTC_1441 4106-0040 13 µM 1.17058452081199 0.133726333940746 no 433 0.120882911132473 619 2904180
SGTC_3345 9148410 3.559 µM 1.16625198480195 0.13463578834229 no 434 0.121756290029456 608 4903596
SGTC_2826 7992541 19.48 µM 1.16456916595638 0.134990175399969 no 435 0.122096715478148 620 2985066
SGTC_3053 9095903 49.47 µM 1.16411547623427 0.135085827918854 no 436 0.122188608811325 640 17174018
SGTC_74 000s-0487 160.283 µM 1.16400211862503 0.135109734637771 no 437 0.122211576595139 628 677548
SGTC_81 0411-0046 9.971 µM 1.16377387887771 0.135157878394357 no 438 0.122257830247489 603 12925265
SGTC_1149 3909-7961 23.3 µM 1.16225152262693 0.135479297517505 no 439 0.122566655875924 638 735261
SGTC_1025 k007-0731 70 µM 1.15767100365771 0.136449551835549 no 440 0.123499160663465 627 6256118
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.15718718732382 0.136552311578285 no 441 0.123597945663707 900 16725076
SGTC_3174 9107204 49.47 µM 1.15539553971612 0.136933307801466 no 442 0.123964243799289 634 3938802
SGTC_2023 5144124 124 µM 1.15471506226999 0.137078202405052 no 443 0.12410356468147 652 2830192
SGTC_2081 5214970 32.255 µM 1.15451161116908 0.137121543743693 no 444 0.12414524050438 633 2063512
SGTC_3172 9105863 49.47 µM 1.15366276557622 0.13730247495671 no 445 0.124319227430286 574 2348785
SGTC_504 lovastatin 124 µM 1.15171467074775 0.137718327102573 no 446 0.124719170831932 581 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1016 4226-1401 38 µM 1.14564305656738 0.139019920595543 no 447 0.12597143705572 678 2901613
SGTC_778 3456-2434 196 µM 1.14411345906378 0.139349142176043 no 448 0.126288293335413 750 5539063
SGTC_1347 1493-0251 600 nM 1.13917568945662 0.140415536536148 no 449 0.127314941555511 707 3986378
SGTC_2470 5664817 21.68 µM 1.13663478733229 0.140966440839478 no 450 0.127845495608939 680 2859561
SGTC_379 3970-0972 5.9 µM 1.13645975980736 0.14100444323475 no 451 0.12788209877941 661 2898042 YBL034C STU1
SGTC_43 0570-0105 72.5 µM 1.13537798637705 0.141239474653065 no 452 0.128108489571909 769 1114046 YDL195W SEC31
SGTC_1478 0453-0656 35.7 µM 1.13417408472271 0.141501352343202 no 453 0.128360766170451 669 5258496
SGTC_2465 5809242 33.21 µM 1.13263369355818 0.141836904160876 no 454 0.128684056564812 672 2731748
SGTC_75 0159-0059 199.013 µM 1.13032743359681 0.142340295934703 no 455 0.129169139473998 647 5377270
SGTC_2440 5628896 157.78 µM 1.12961117068118 0.142496881700297 no 456 0.129320050957201 666 5522048
SGTC_2514 salinomycin 42.74 µM 1.12758884493829 0.142939620957647 no 457 0.129746799953875 764 23682228 A polyether potassium ionophore.
SGTC_2364 9055074 200 µM 1.12745484225111 0.142968990405085 no 458 0.129775111467574 643 6470630
SGTC_1353 1498-1206 8.11 µM 1.12600491409449 0.143287032768342 no 459 0.13008171965446 749 6756808
SGTC_3250 9135583 49.47 µM 1.12479164004276 0.143553531872267 no 460 0.130338668919839 645 7699353
SGTC_1068 loratadine 26.9 µM 1.12418731987404 0.143686397267098 no 461 0.130466783793728 650 3957 A H1 histamine antagonist.
SGTC_2459 5811157 9.22 µM 1.1240520844049 0.143716141399029 no 462 0.130495465410574 661 2870684 YBR192W RIM2
SGTC_2558 carylophyllene oxide 100 µM 1.11854327350621 0.144931299595732 no 463 0.131667517742239 728 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2087 5276107 200 µM 1.11825486841572 0.144995107272362 no 464 0.131729078171547 692 144405
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.11804968752384 0.145040513668412 no 465 0.131772886379602 809 688664
SGTC_2904 7225135 42.03 µM 1.11755910647683 0.145149117726949 no 466 0.131877671170165 724 4446116
SGTC_1953 st076800 12.1 µM 1.11682850195304 0.145310959220224 no 467 0.132033829867449 697 297591
SGTC_1023 4482-3888 16 µM 1.11647284155466 0.14538978804549 no 468 0.13210989450289 688 3303168
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.11292638860243 0.146177399790076 no 469 0.132870022770765 623 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2648 atorvastatin 78.68 µM 1.11254824333719 0.146261548695074 no 470 0.132951249772243 673 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2979 9012552 45.46 µM 1.11154486686844 0.146484988345776 no 471 0.133166944425804 634 17100905
SGTC_2865 9030313 51.95 µM 1.11049123718133 0.146719865281458 no 472 0.133393701037827 645 42562754
SGTC_2149 5554786 194.827 µM 1.11044725036353 0.146729676390029 no 473 0.133403173420612 726 745063 YPR165W RHO1
SGTC_3286 9117135 37.221 µM 1.10978581908322 0.146877259439938 no 474 0.13354566575496 663 3438150
SGTC_191 3914-0123 66.505 µM 1.10891286291675 0.147072191736749 no 475 0.133733887137789 549 3144412
SGTC_3312 9133330 71.43 µM 1.10870341531295 0.147118987462233 no 476 0.133779074042652 749 17617324
SGTC_391 gliotoxin 8.33 µM 1.10840204206319 0.147186339143503 no 477 0.133844111698343 739 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1640 st009078 66.4 µM 1.10681331706739 0.147541733211552 no 478 0.13418732467883 627 690618
SGTC_2085 5307070 144.047 µM 1.10496128931807 0.147956752601017 no 479 0.134588181589953 646 2840351
SGTC_1022 4477-0945 21.3 µM 1.10281799615081 0.148438015977917 no 480 0.13505310567084 707 4648966
SGTC_1701 st028638 40.4 µM 1.1009717606031 0.148853415287479 no 481 0.135454473923464 717 3490878
SGTC_2266 7929956 200 µM 1.10012420913061 0.149044372590332 no 482 0.13563900356541 723 2967153
SGTC_1656 st012921 11 µM 1.09940053179907 0.149207549927879 no 483 0.135796699458959 664 6732821
SGTC_1032 k061-1018 98.7 µM 1.09824558491119 0.149468218501352 no 484 0.136048632932536 794 4005393
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.09764035634868 0.149604938351154 no 485 0.136180781693167 715 229346 A bile salt which induces apoptosis.
SGTC_2779 methotrexate 400 µM 1.09740247240209 0.149658698669229 no 486 0.136232746555986 745 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2287 7945887 168.79 µM 1.09707062317594 0.149733716096188 no 487 0.136305260449234 756 1245853
SGTC_2464 5717415 7.67 µM 1.09395633333511 0.150438950870631 no 488 0.136987065032452 701 5285744
SGTC_1092 toremifene 6.32 µM 1.09254852203249 0.150758476582431 no 489 0.137296037619317 758 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_272 doxorubicin 8.13 µM 1.08469647124712 0.152548910990476 no 490 0.139028055643093 766 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2512 diallyl trisulfide 49.23 µM 1.08254480740836 0.153041988832566 no 491 0.139505258346684 678 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1007 4101-0031 70 µM 1.08168840124943 0.153238537493741 no 492 0.139695504361169 751 1146276
SGTC_758 0868-0029 16 µM 1.08167646456665 0.153241278191886 no 493 0.139698157276787 728 762687
SGTC_452 diindolylmethane 8 µM 1.07982085099885 0.153667727629214 no 494 0.140110982099506 663 3071 Inhibits expression of several cancer promoting factors.
SGTC_2394 5221648 200 µM 1.07885131960984 0.153890853541192 no 495 0.140327006449199 818 788586
SGTC_2395 5646831 180.19 µM 1.0781180318163 0.154059753186545 no 496 0.140490542771695 741 6808628
SGTC_2757 clomiphene 4.22 µM 1.07522552054992 0.154727186674009 no 497 0.141136886092899 816 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1943 st076331 65.2 µM 1.0750539466118 0.154766836493761 no 498 0.141175288227376 758 24208415
SGTC_1200 1643-0193 18.4 µM 1.07413258066454 0.154979874044025 no 499 0.1413816319687 770 5403974
SGTC_531 3788-1495 174 µM 1.07325759754619 0.155182366189959 no 500 0.141577777225789 700 2896655
SGTC_1235 benzylparaben 21.5 µM 1.07323950118483 0.155186555965993 no 501 0.141581835838143 692 7180
SGTC_1859 st055998 20 µM 1.07248756275742 0.155360715190445 no 502 0.141750548633484 755 676301
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.07247221576578 0.155364271106207 no 503 0.141753993462881 692 279621
SGTC_357 1325-0123 420 µM 1.07075125537239 0.155763360322814 no 504 0.142140644824033 706 1098503
SGTC_3322 9139058 2.11 µM 1.07024443453708 0.155881020371174 no 505 0.142254649128873 753 4908926 YPR165W RHO1
SGTC_696 1560-0013 611 µM 1.06750817197093 0.156517264157377 no 506 0.142871212726665 737 1650269
SGTC_1217 1183-1422 255 µM 1.06505582396366 0.157088942221933 no 507 0.143425334276342 783 2849664
SGTC_150 3970-0969 77.2 µM 1.06306285321987 0.15755454300544 no 508 0.143876724402929 796 6615640
SGTC_37 0566-0070 1.56 µM 1.06222917389159 0.157749577131884 no 509 0.144065829329004 796 1626686
SGTC_2728 chlorpromazine 9.18 µM 1.06148650440372 0.157923453570758 no 510 0.144234431436518 629 2726 A thorazine and dopamine antagonist.
SGTC_2549 cedrol 20.94 µM 1.05886958453751 0.158537138800129 no 511 0.144829588915309 685 6708665 A sedative which affects the nervous system.
SGTC_2079 5212404 121 µM 1.05845439828628 0.158634646315658 no 512 0.144924165136167 755 758462
SGTC_2495 cafestol 54.53 µM 1.05731277243357 0.158902962641932 no 513 0.145184432999721 685 16667697 An anti-infammatory.
SGTC_258 haloperidol 50.781 µM 1.0570560137251 0.158963349586391 no 514 0.145243012148652 721 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1379 2144-0755 36.5 µM 1.05580875139747 0.15925690647447 no 515 0.145527799588069 799 5392327
SGTC_2203 7227154 166.4 µM 1.05578284246656 0.159263008187601 no 516 0.145533719353449 719 896304
SGTC_1653 st012112 65 µM 1.0555659086699 0.159314103443095 no 517 0.145583291518905 707 720429
SGTC_3143 9086658 49.47 µM 1.05434201772212 0.159602572300602 no 518 0.145863179066219 827 25236626
SGTC_1158 4092-0494 91.8 µM 1.05392183869703 0.159701686504431 no 519 0.145959351741564 783 1148199
SGTC_2714 st079313 56.9 µM 1.0521307416012 0.16012463225949 no 520 0.146369784828279 729 2939799
SGTC_2251 lansoprazole 556 µM 1.05005471884862 0.160615775218088 no 521 0.146846477851198 598 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1131 3454-3128 32.3 µM 1.04984379792414 0.160665729640354 no 522 0.146894967388168 798 710982
SGTC_2698 st077697 67.5 µM 1.04874231581806 0.160926769033751 no 523 0.147148366416503 704 3154499
SGTC_157 1348-1695 65.819 µM 1.04873237093273 0.160929127124796 no 524 0.147150655599174 783 5380510
SGTC_31 0508-1974 57.237 µM 1.04647013422043 0.161466125672752 no 525 0.147672013415672 737 6810525
SGTC_2537 larixol 68.93 µM 1.04450502357732 0.161933541110722 no 526 0.148125898102766 812 6708759
SGTC_759 3486-0358 89.3 µM 1.04133257130816 0.162689989571749 no 527 0.148860612500234 830 875103
SGTC_213 1246-0773 967 nM 1.037791596973 0.163537019611967 no 528 0.149683544892788 789 6251622
SGTC_3067 9117431 49.47 µM 1.03421801098989 0.164394748791404 no 529 0.150517127975509 716 17150885
SGTC_1864 st057645 30.4 µM 1.03187080873321 0.164959706310855 no 530 0.151066321275734 759 688666
SGTC_3268 9137683 49.47 µM 1.02926076444165 0.165589402826017 no 531 0.151678577605488 747 1953228
SGTC_841 0251-0215 91.2 µM 1.02825856087549 0.165831605912107 no 532 0.151914109106867 811 3888614
SGTC_554 4483-2211 187 µM 1.02714448555335 0.166101113739152 no 533 0.152176217017504 759 747107
SGTC_2984 9022109 38.96 µM 1.02536320971561 0.166532612744156 no 534 0.152595920363746 758 6459207
SGTC_709 3807-1509 243 µM 1.02355194361527 0.166972117911601 no 535 0.15302347675671 770 1886677 YPL242C IQG1
SGTC_3237 9133362 49.47 µM 1.02352993976272 0.166977461759029 no 536 0.153028675729112 777 43845137
SGTC_83 0170-0301 39.027 µM 1.02336708779144 0.167017015357078 no 537 0.153067157308647 706 3089716
SGTC_351 caspofungin 25 nM 1.01784556219897 0.168361661862292 no 538 0.154375677772361 907 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1315 1237-0019 3.69 µM 1.01615431227782 0.168774917749176 no 539 0.154777954475285 827 825140
SGTC_257 daunorubicin 18.5 µM 1.0159417006116 0.168826915363774 no 540 0.154828574742281 786 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1922 5578187 25 µM 1.01552602101751 0.168928606249198 no 541 0.154927574617132 737 1350412
SGTC_619 1652-1634 108 µM 1.01464864396068 0.169143374870524 no 542 0.155136671387481 725 5400454
SGTC_3280 9140961 49.47 µM 1.01426805110055 0.169236592740206 no 543 0.155227432307137 752 4901226
SGTC_464 bw-b 70c 158 µM 1.01296637778795 0.1695556582989 no 544 0.155538110435538 818 5353454
SGTC_1905 st060207 84.5 µM 1.01288635614089 0.169575285752095 no 545 0.155557223053451 781 1948547
SGTC_1341 1486-1360 280 µM 1.01281986649901 0.169591595227113 no 546 0.155573104823737 788 3976547
SGTC_2086 5274770 176.623 µM 1.01180706973313 0.16984015206398 no 547 0.155815154516512 789 689278
SGTC_1956 st077085 54 µM 1.0101635837752 0.170243987105013 no 548 0.156208461585534 821 24208685
SGTC_2992 9074591 71.4286 µM 1.00941395867799 0.170428388048053 no 549 0.156388073411023 762 17741321
SGTC_1798 st045719 60.953 µM 1.00806727303927 0.170759981634417 no 550 0.156711083779555 753 3980186
SGTC_937 3122-0005 46.7 µM 1.00699678085065 0.171023862642484 no 551 0.156968160582891 843 759535
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.00557443285423 0.171374880960082 no 552 0.157310163891128 779 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_281 1672-3440 14.9 µM 1.00528753250518 0.171445740278139 no 553 0.157379208353274 851 6833000
SGTC_125 0133-0007 11.75 µM 1.00476097839936 0.171575838553621 no 554 0.157505978893355 885 26541
SGTC_2723 salbutamol 83.58 µM 1.00454246272545 0.171629846795866 no 555 0.157558607334148 709 9884233 β2-adrenoceptor agonist
SGTC_2580 diallyl disulphide 81.36 µM 1.00392626004246 0.171782205684369 no 556 0.157707078991565 750 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2457 5731572 11.68 µM 1.00071155702634 0.172578455756884 no 557 0.158483139218763 812 2865357
SGTC_3123 9126162 49.47 µM 1.00053103577351 0.172623238761277 no 558 0.158526792938345 782 25239884
SGTC_2592 piperlongumine 83.33 µM 1.00036988092063 0.17266322368418 no 559 0.158565770129342 744 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.995442290849957 0.173888682045503 no 560 0.159760599302102 795 616764
SGTC_1841 st054148 70 µM 0.99528990729314 0.173926666764276 no 561 0.159797642523387 748 675442
SGTC_106 0092-0003 11.579 µM 0.994696748158067 0.174074574049101 no 562 0.159941888256404 744 1072148
SGTC_109 0132-0036 33.701 µM 0.993470619183903 0.174380569005751 no 563 0.160240330847919 689 67274 A color developer.
SGTC_947 3447-0010 211 µM 0.992945226521072 0.17451179146497 no 564 0.160368323952225 790 748350
SGTC_698 k064-0052 127 µM 0.992721357359997 0.174567724241596 no 565 0.16042288194769 819 5088751
SGTC_1093 fluphenazine 7.97 µM 0.992177106727682 0.17470375046821 no 566 0.160555569029722 823 6602611 An atypical antipsychotic.
SGTC_2970 9090938 41.86 µM 0.992123146902844 0.174717240478027 no 567 0.160568728218946 869 17217104
SGTC_2729 fluphenazine 10.66 µM 0.989711421669505 0.175320849379546 no 568 0.161157595344607 833 3372 An atypical antipsychotic.
SGTC_647 0140-0236 81 µM 0.986744894500291 0.176065125772864 no 569 0.161883857653316 904 990837
SGTC_3225 9130819 49.47 µM 0.985046004009723 0.176492262371952 no 570 0.162300737152544 824 4547121
SGTC_2727 riluzole 51.77 µM 0.984169483471482 0.176712894070324 no 571 0.16251609378241 760 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2408 sulbentine 18.36 µM 0.983645258571275 0.176844931638139 no 572 0.162644981987338 806 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2371 9071574 200 µM 0.983457014134403 0.176892360351106 no 573 0.162691280802128 778 45596039
SGTC_817 1391-0715 46 µM 0.983041727507351 0.176997021406768 no 574 0.162793451073979 781 1353946
SGTC_3074 9116018 49.47 µM 0.981459320790751 0.177396180025816 no 575 0.16318314266049 782 17027303
SGTC_3163 9099914 49.47 µM 0.980040112671446 0.177754655177965 no 576 0.163533159334278 796 16268368
SGTC_2434 5670830 169.91 µM 0.97938011928867 0.17792151725308 no 577 0.163696098240038 806 1549830
SGTC_1328 1441-0025 69.2 µM 0.979191207776839 0.177969296769064 no 578 0.163742756033483 776 4562601
SGTC_2881 9058953 51.95 µM 0.97768288260726 0.178351072649014 no 579 0.164115595182989 892 17122249
SGTC_25 0118-0223 35.662 µM 0.976281871743412 0.178706147839356 no 580 0.164462400466933 825 5333628
SGTC_2135 5326629 150.42 µM 0.9746734881635 0.179114328384989 no 581 0.164861123919618 761 5020077
SGTC_2540 epiandrosterone 100 µM 0.973652676652645 0.179373697082266 no 582 0.165114510877447 999 441302 A steroid.
SGTC_2688 kanamycin b 96.69 µM 0.972241658828306 0.179732598325688 no 583 0.165465170126301 1169 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3217 9129673 49.47 µM 0.971611342950866 0.179893068810634 no 584 0.165621968696745 781 17248312
SGTC_1157 4092-0394 27.6 µM 0.970483215874435 0.180180500325582 no 585 0.165902843529894 893 3659885
SGTC_2953 9074162 66.49 µM 0.970237281549926 0.180243199314264 no 586 0.165964115745489 769 16451992
SGTC_60 0986-0278 202 µM 0.966734393661414 0.18113771852466 no 587 0.166838414415098 696 3110598
SGTC_399 oxolinic acid 75 µM 0.966369827837919 0.181230975826034 no 588 0.166929578142845 815 4628 A DNA gyrase inhibitor.
SGTC_98 0074-0023 107.663 µM 0.965887676614933 0.181354358085634 no 589 0.167050194739077 864 3563821
SGTC_1018 4259-0013 28.1 µM 0.964490178521557 0.181712274211864 no 590 0.167400115058228 813 6801262
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.963932086628221 0.181855331684045 no 591 0.167539987873031 821 140250 A respiratory chain inhibitor.
SGTC_929 2805-0021 398 µM 0.962175233507272 0.182306131186715 no 592 0.167980793829045 820 3098024
SGTC_2760 etidronate 98.04 µM 0.962158567209379 0.182310411014133 no 593 0.167984979083421 793 3305 A chelator and antioxidant.
SGTC_2138 5575593 77.673 µM 0.96091271891598 0.182630516779381 no 594 0.168298027543319 830 762213
SGTC_1412 3909-8563 178 µM 0.95825031065868 0.183315766183548 no 595 0.16896827665631 940 23767530
SGTC_2343 7990716 14.84 µM 0.957927091481397 0.183399065178947 no 596 0.169049762160963 852 6456862
SGTC_2781 5567276 71.43 µM 0.955547175206185 0.184013135805869 no 597 0.169650530297042 809 2853274
SGTC_2349 9023730 187.07 µM 0.955496167449932 0.184026310923502 no 598 0.169663421283451 844 4126287
SGTC_207 4185-0010 4.486 µM 0.950062039618653 0.185433289248678 no 599 0.171040365045984 947 3761753
SGTC_3192 9110362 49.47 µM 0.948681084694471 0.185791900775801 no 600 0.171391418601038 886 16649480
SGTC_1915 st067105 30.6 µM 0.947193466761489 0.186178691884789 no 601 0.171770101938655 843 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1184 1269-1718 139 µM 0.946802012668663 0.186280555577544 no 602 0.171869838004524 874 5403821
SGTC_711 k292-0785 179 µM 0.946755496354915 0.186292662289485 no 603 0.171881692054107 885 4146315
SGTC_1802 st050112 57.9 µM 0.945463196954875 0.186629201470987 no 604 0.17221122568094 872 4662563
SGTC_2940 9060638 45.86 µM 0.945150137929613 0.18671078456082 no 605 0.172291115695479 829 4027022
SGTC_46 0329-0187a 2.197 µM 0.944188818004489 0.186961442204566 no 606 0.172536584167016 929 46494817
SGTC_2480 5767542 37.17 µM 0.943724588387332 0.187082561437442 no 607 0.172655202805863 886 2867358
SGTC_1205 4161-2785 76 µM 0.942922878735404 0.187291844718876 no 608 0.172860175781236 761 3498106
SGTC_2795 7780010 54.55 µM 0.942284047361447 0.187458712822359 no 609 0.173023616663675 811 953673
SGTC_546 peri-Naphthalide 147 µM 0.941937740514942 0.187549209464879 no 610 0.173112258170271 858 223824 A penicillin ester.
SGTC_1514 1189-1591 158 µM 0.939931535469247 0.188074000476803 no 611 0.173626340090473 880 767698 YMR146C TIF34
SGTC_2180 6301957 200 µM 0.936685795852578 0.188924950961649 no 612 0.17446010240441 898 845462
SGTC_1241 0364-0022 50.8 µM 0.935572130015714 0.189217471590113 no 613 0.174746764785666 878 4563895
SGTC_2770 toltrazuril 17.5 µM 0.9338377352307 0.189673590742579 no 614 0.175193800549447 915 68591 Kills coccidiodes.
SGTC_534 k292-0788 63.4 µM 0.933631335025633 0.189727915816728 no 615 0.17524704791886 963 4146317
SGTC_835 0312-0010 67.2 µM 0.932602961739911 0.189998728951341 no 616 0.175512501808866 837 1626196
SGTC_1045 1348-1485 165 µM 0.931962975011668 0.190167383756551 no 617 0.175677830099438 980 6810614
SGTC_400 oxethazaine 37.5 µM 0.931440677828404 0.190305092147745 no 618 0.175812828652605 836 4621 A local anesthetic.
SGTC_1526 st051518 75 µM 0.931120664675423 0.190389496774257 no 619 0.175895575152823 799 673993
SGTC_3181 9108277 49.47 µM 0.929768009295861 0.190746518430618 no 620 0.176245606604294 844 17097298
SGTC_1775 st081588 35.1725 µM 0.927758386354881 0.191277699011768 no 621 0.176766457231569 907 1426443 YGL099W LSG1
SGTC_463 ikarugamyin 104 µM 0.926532977423324 0.191602041854939 no 622 0.177084533690014 885 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_268 camptothecin 39.6153 µM 0.924673534617913 0.192094844581851 no 623 0.177567874930976 961 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1469 k284-2957 126 µM 0.924580381891944 0.192119552960717 no 624 0.177592110814416 884 23884841
SGTC_2692 st077426 47.7 µM 0.920438663597216 0.193220091160781 no 625 0.178671785954104 915 25238571
SGTC_818 4072-2707 53.5 µM 0.920199710166812 0.19328370310132 no 626 0.17873420287736 873 882871
SGTC_1902 st060212 70.5 µM 0.919572442629496 0.193450749181224 no 627 0.178898116469439 913 688944
SGTC_626 0214-0009 33 µM 0.918790161344639 0.193659199960344 no 628 0.179102669795588 923 3437874
SGTC_79 0052-0007 94.094 µM 0.918593212555247 0.193711701543079 no 629 0.179154191749239 898 2801472
SGTC_2885 9057732 51.95 µM 0.917486161992098 0.194006974773326 no 630 0.179443970479476 893 6471414
SGTC_2811 7967822 32.47 µM 0.91435920906651 0.194842477766503 no 631 0.180264064113358 879 2232244
SGTC_2265 7929201 200 µM 0.913894731274624 0.194966769841676 no 632 0.180386081207744 947 1265108
SGTC_1554 st069299 38.7 µM 0.913864976529103 0.194974733714515 no 633 0.180393899466824 882 24207999
SGTC_1301 naphtanilide LB 4.81 µM 0.912392610761519 0.195369060172082 no 634 0.180781038972063 961 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2280 7785178 200 µM 0.911480772293768 0.195613509919641 no 635 0.181021056043543 873 2954328
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.911317210985153 0.195657377803921 no 636 0.181064130290577 958 6708561
SGTC_675 1309-0189 238 µM 0.911161489850274 0.195699148467466 no 637 0.181105145776483 850 4246530
SGTC_3113 9123498 49.47 µM 0.910690319769045 0.195825568175116 no 638 0.181229283000456 931 8897275
SGTC_298 1391-0729 10 µM 0.907996271474184 0.196549360010224 no 639 0.181940095785841 890 3237558
SGTC_3038 9091290 49.47 µM 0.907917522826911 0.196570541233117 no 640 0.181960899461871 881 25236843
SGTC_914 3820-6779 408 µM 0.907821275935214 0.196596430881045 no 641 0.181986327812603 896 2893481
SGTC_893 0958-0369 48.9 µM 0.907610288606073 0.196653192020926 no 642 0.18204207826784 922 6819948
SGTC_614 0462-0418 107 µM 0.90322679124097 0.197834712495592 no 643 0.183202770811352 822 5188303
SGTC_2194 5927483 104.545 µM 0.902960966271894 0.197906500169267 no 644 0.18327330589811 963 760979
SGTC_1898 st060199 18.6 µM 0.902787708141467 0.19795329806603 no 645 0.18331928803525 894 688866
SGTC_2291 7917025 104.35 µM 0.90161887755689 0.19826917972179 no 646 0.183629679749133 860 2964612
SGTC_171 k064-0041 9.68 µM 0.900412973082176 0.198595399428975 no 647 0.183950259722571 825 53325
SGTC_2044 5102272 200 µM 0.900284889035772 0.198630067566493 no 648 0.183984330294854 836 592666
SGTC_582 0987-0078 156 µM 0.900256493015006 0.198637753929361 no 649 0.183991884216334 1024 1625765
SGTC_462 ag-879 158 µM 0.899993052251351 0.198709071813782 no 650 0.184061974045975 951 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_441 propafenone 146 µM 0.899836309878394 0.19875151195863 no 651 0.18410368408196 903 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2889 9059656 51.95 µM 0.893378004243808 0.200504934704809 no 652 0.185827388879882 958 3949838
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.89241815372927 0.20076632371249 no 653 0.18608442214881 1006 688801
SGTC_3033 9090887 49.47 µM 0.890801248449146 0.201207105773617 no 654 0.186517902641327 940 19325384
SGTC_1749 st037932 54.2 µM 0.89011603709641 0.201394075106756 no 655 0.186701791307681 855 594497
SGTC_90 0870-0863 4.608 µM 0.889013408316647 0.201695161032659 no 656 0.186997936890074 947 1738164
SGTC_3276 9139060 49.47 µM 0.888194552317468 0.201918933772946 no 657 0.187218054322394 912 4870619
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.888043244404182 0.201960298680878 no 658 0.187258745072609 991 16486 A toxic proline analog.
SGTC_13 0199-0087 65 µM 0.886701747723595 0.202327261948258 no 659 0.187619748579595 982 4589825
SGTC_299 1273-0059 1.44 µM 0.886599470712406 0.20235525593603 no 660 0.187647289467778 888 2848077
SGTC_1605 st000082 49.1 µM 0.886199652466049 0.202464711423976 no 661 0.187754975451487 941 1114022
SGTC_2962 9082311 13.18 µM 0.884734605273474 0.202866089705363 no 662 0.188149893457493 885 16459453
SGTC_3309 9129340 25.759 µM 0.884656066486973 0.202887620354497 no 663 0.188171078833791 969 17158987
SGTC_86 0417-1630 471.922 µM 0.884043855778064 0.203055498785883 no 664 0.188336269532349 1027 3634867
SGTC_3082 9117008 49.47 µM 0.883948461312697 0.203081665013168 no 665 0.188362017544453 930 41448529
SGTC_2846 9008642 19.48 µM 0.883079798892769 0.203320027412558 no 666 0.188596578954716 867 2992898
SGTC_51 1013-0126 23.419 µM 0.883078133827081 0.203320484469581 no 667 0.188597028738546 904 1627850
SGTC_40 0327-0103 19.753 µM 0.882620816466055 0.203446040329613 no 668 0.188720588811827 891 409036
SGTC_2231 micatex 6.853 µM 0.881268557397468 0.203817571718915 no 669 0.18908624009152 955 20737 An antifungal of unknown mechanism.
SGTC_2963 9082507 9 µM 0.877323733230751 0.204903715208909 no 670 0.190155412443412 864 16459611
SGTC_2997 9067075 71.4286 µM 0.877053709128634 0.204978187609131 no 671 0.190228733120815 944 27209819
SGTC_300 r073-0011 5.04 µM 0.876990714065509 0.204995563904427 no 672 0.190245840909649 1002 2735780
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.875876238272219 0.205303121009992 no 673 0.190548659243822 990 23665772 A membrane-active detergent.
SGTC_421 streptovitacin 30 mM 0.874082127439274 0.205798809493302 no 674 0.191036764938883 960 91467 include heat shock
SGTC_2242 6630449 61.2675 µM 0.87391216252269 0.205845805289306 no 675 0.191083045313854 837 691249 YDR170C SEC7
SGTC_3171 9103192 49.47 µM 0.869614816876743 0.207036148239652 no 676 0.192255468881343 994 13018434
SGTC_2571 chrysanthemic acid 100 µM 0.868730509604946 0.207281601174701 no 677 0.192497274819095 876 2743 An insecticide.
SGTC_1049 3226-0134 66 µM 0.868430499650307 0.207364912577498 no 678 0.192579352085398 970 5702385
SGTC_984 1492-0255 2.91 µM 0.867829675326198 0.207531818276631 no 679 0.19274379099393 906 1585198
SGTC_410 α-linolenic acid 100 µM 0.865690985761752 0.208126578446554 no 680 0.193329822323441 976 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_953 1188-0045 9.7 µM 0.865579039025237 0.208157738022997 no 681 0.193360527236328 961 6144426
SGTC_2051 5263410 176 µM 0.865546587893702 0.208166771078893 no 682 0.193369428535918 995 227584
SGTC_2869 9037858 32.47 µM 0.86525743606125 0.208247269229901 no 683 0.19344875351444 961 27187042
SGTC_1952 st077036 64.1 µM 0.863616147066907 0.208704542209014 no 684 0.193899395472385 1005 2937007
SGTC_2053 5265679 138 µM 0.861339143451215 0.209339908143923 no 685 0.194525641444833 970 764595
SGTC_406 estrone 100 µM 0.861265760248469 0.209360403614201 no 686 0.194545844535055 977 5870 A steroid.
SGTC_593 1203-0218 61.7 µM 0.861164766380526 0.209388612501662 no 687 0.19457365119069 1001 3666956
SGTC_2661 dactinomycin 12.96 µM 0.860809130275528 0.209487964047098 no 688 0.194671587781229 994 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3092 9117248 49.47 µM 0.860579447561726 0.209552143620519 no 689 0.194734854725671 1021 17141857
SGTC_952 1185-0122 232 µM 0.860142009755563 0.209674407580423 no 690 0.194855383162017 949 678600
SGTC_2098 5376439 882.5 nM 0.860109641572459 0.209683456161025 no 691 0.194864303458519 1001 2844116
SGTC_2952 9073731 13.78 µM 0.859809982813139 0.209767237179166 no 692 0.194946897734894 1005 16457353
SGTC_2534 helenine 20.12 µM 0.859181798947159 0.20994293376299 no 693 0.195120111726034 927 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1324 1418-0026 34.4 µM 0.858451033952401 0.210147430017409 no 694 0.195321728868738 961 1372513
SGTC_3279 9140807 49.47 µM 0.857500948001244 0.210413475615013 no 695 0.195584045558069 971 45595718
SGTC_2092 5303694 80.6725 µM 0.85712034118099 0.210520109594825 no 696 0.195689190265669 943 1963699
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.856858682286407 0.210593436525352 no 697 0.195761494860603 990 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_989 1501-0895 10.3 µM 0.856137644454272 0.210795576716225 no 698 0.19596082421757 983 2830112
SGTC_3037 9091026 49.47 µM 0.856066794364638 0.210815445405628 no 699 0.195980417214305 1030 25236398 YIL048W NEO1
SGTC_407 eburnamonine 100 µM 0.855532231348153 0.210965389813958 no 700 0.19612828443033 911 3195
SGTC_162 k030-0015 37.8 µM 0.854042530092694 0.211383579344026 no 701 0.196540712406752 1033 1809920 YMR134W ERG29
SGTC_1292 0kpi-0043 232 µM 0.85396768957661 0.211404601404379 no 702 0.196561446067448 924 3333905
SGTC_2155 5570423 76 µM 0.853289263008392 0.211595221470652 no 703 0.196749456399791 889 797402
SGTC_1925 st057770 10.1 µM 0.852966066654755 0.211686066540021 no 704 0.196839061129353 882 5989122
SGTC_1321 1326-2144 215 µM 0.85290216242536 0.211704031648788 no 705 0.196856781213818 988 3513030
SGTC_2694 st077685 81.9 µM 0.85219199938618 0.211903736641113 no 706 0.197053768221319 938 2838096
SGTC_2294 7971431 200 µM 0.851315775758468 0.212150291348331 no 707 0.19729698191546 884 5741572
SGTC_2316 5844804 197.44 µM 0.850748380500217 0.212310036332675 no 708 0.19745457082901 1095 776813
SGTC_1680 diphenhydramine 100 µM 0.850599986371309 0.212351826946519 no 709 0.197495798512113 932 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3337 9144342 33.5465 µM 0.849771397662406 0.21258526165252 no 710 0.197726097291393 972 17682949
SGTC_1391 3442-0225 151 µM 0.849593854654196 0.21263529956489 no 711 0.197775464877797 934 5227075
SGTC_1626 st003712 1.76 µM 0.847917934496638 0.213107972047242 no 712 0.19824183790012 903 24207035
SGTC_1297 1068-0111 14.1 µM 0.847895843800451 0.213114206543854 no 713 0.198247989701543 936 767057
SGTC_492 tmb-8 126 µM 0.847236857693205 0.213300236322394 no 714 0.198431556670609 840 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2990 9074105 71.4286 µM 0.846306830140731 0.213562941316616 no 715 0.198690799293415 966 6502001
SGTC_1192 1488-0095 21.4 µM 0.845004436686623 0.213931145242038 no 716 0.199054180954806 934 915875
SGTC_1880 MG-132 525 µM 0.844464815652241 0.214083811496965 no 717 0.199204858226194 930 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_712 r015-0009 80.6 µM 0.843206366514626 0.214440090413437 no 718 0.19955651920886 914 6813872 YLR060W FRS1
SGTC_795 0685-0265 78 µM 0.842321329673818 0.214690859122468 no 719 0.199804057499002 1047 302754
SGTC_2629 bisabolol 100 µM 0.841243638789578 0.214996444925321 no 720 0.200105728957174 984 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1944 st076371 56.9 µM 0.838973298021473 0.21564103976779 no 721 0.200742146907163 930 24208455
SGTC_1774 st048371 48.465 µM 0.838410562185479 0.215800984772094 no 722 0.200900079718246 1025 4242727
SGTC_2850 9015429 58.44 µM 0.837989107563634 0.215920818788283 no 723 0.201018410518695 966 6457570
SGTC_2842 9000675 19.48 µM 0.837284366439947 0.216121286999885 no 724 0.201216372370398 943 2989072
SGTC_1941 st076221 61.8 µM 0.836394790268375 0.216374486588494 no 725 0.201466421234344 1006 2828568
SGTC_1078 idebenone 36.1 µM 0.833882942513745 0.217090358629045 no 726 0.202173475093395 1017 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.83368492526557 0.217146851319033 no 727 0.202229277543716 1028 23847180
SGTC_748 act1.228 77.9 µM 0.833208200309091 0.217282891853779 no 728 0.202363659288427 990 4421505 YNR035C ARC35
SGTC_3320 9137005 35.139 µM 0.828657579192316 0.218583954220857 no 729 0.203649098165861 921 4908713
SGTC_3351 9150312 21.596 µM 0.82845017191511 0.218643360452699 no 730 0.203707801415584 976 4904905
SGTC_1692 fluoroquinolonic acid 71 µM 0.827323922889722 0.218966106382386 no 731 0.204026743939935 982 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1637 st007924 17.4 µM 0.827063392045711 0.219040804961807 no 732 0.204100566032918 963 683336
SGTC_1331 1472-0049 76.2 µM 0.825981229300968 0.219351236052541 no 733 0.204407369921925 985 24051409
SGTC_1100 amiodarone 5.07 µM 0.824740333720958 0.219707512490291 no 734 0.204759513813998 1050 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2789 5281112 71.43 µM 0.823766115263092 0.21998745530134 no 735 0.205036232200263 975 765948
SGTC_999 SEC7.066 22.7 µM 0.823068048036133 0.220188171532565 no 736 0.205234648833239 1055 740511 YDR170C SEC7
SGTC_2725 haloperidol 53.21 µM 0.822530686657784 0.220342751303632 no 737 0.205387464574393 1014 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2245 6637752 200 µM 0.821366607356275 0.220677828817229 no 738 0.20571873909987 951 681890
SGTC_2897 9048598 12.99 µM 0.816609172423038 0.222050275447314 no 739 0.20707590579987 1009 6467404
SGTC_3030 9087619 49.47 µM 0.815330238823287 0.222420057407063 no 740 0.207441652145442 1038 25236973
SGTC_2033 5192550 145 µM 0.814890185911786 0.222547372412383 no 741 0.207567585660325 1019 182073
SGTC_226 1,3-diallylurea 8.28947 mM 0.814510928736157 0.222657131477802 no 742 0.207676157004224 994 74537 YKL182W FAS1
SGTC_1726 st035556 14.5795 µM 0.814188654704173 0.222750423561007 no 743 0.207768441937186 1039 5919439
SGTC_349 k015-0014 24 µM 0.814167996939502 0.222756404342943 no 744 0.20777435822714 953 2196908
SGTC_1054 3429-0080 167 µM 0.81302694155173 0.22308690181343 no 745 0.20810130582908 1050 1162877
SGTC_721 1187-1332 279 µM 0.812195488453472 0.223327901234362 no 746 0.208339733942699 914 25730
SGTC_153 4077-0274 519.67 µM 0.811993434864878 0.223386489502305 no 747 0.20839769930968 990 3121976
SGTC_296 1222-0039 74.9 µM 0.808571730888717 0.224379987666385 no 748 0.209380765361309 1001 5984176
SGTC_209 4077-0173 175.592 µM 0.807989351564393 0.224549331999727 no 749 0.209548356068586 929 15993494
SGTC_2133 5320837 200 µM 0.807988241063928 0.224549654980444 no 750 0.209548675711533 975 2841355
SGTC_3048 9093155 49.47 µM 0.807858776045405 0.224587310714916 no 751 0.209585942479344 1002 25236002
SGTC_188 3229-0966 278.469 µM 0.807594354230692 0.224664230631878 no 752 0.209662068944673 1141 5722370
SGTC_438 sphingosine 6.67 µM 0.807235178903104 0.224768738136362 no 753 0.20976550078097 982 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_658 3253-0951 102 µM 0.80131485818881 0.226495312312448 no 754 0.211474695645997 1083 1184878
SGTC_637 1181-0519 7.26 µM 0.800762855603156 0.22665667648733 no 755 0.21163447320114 1105 6252091 YGR060W ERG25
SGTC_693 4161-2696 114 µM 0.798877447593776 0.227208317449324 no 756 0.212180738527289 1004 805759
SGTC_801 0866-0028 10.1 µM 0.797822898353248 0.227517191783152 no 757 0.212486635588808 1069 6849771
SGTC_1785 bathophenanthroline 24 µM 0.797639650713064 0.227570888577086 no 758 0.212539817181594 984 72812 An iron chelator.
SGTC_824 1304-0008 100 µM 0.796692656625077 0.227848498601783 no 759 0.212814774908409 1038 768245
SGTC_2002 4023503 131 µM 0.796671347080255 0.227854747657248 no 760 0.212820964477353 1139 4736863 YCR052W RSC6
SGTC_741 4582-0002 126 µM 0.795910878693188 0.228077819254593 no 761 0.213041918852292 1016 2912688
SGTC_751 0833-0568 350 µM 0.795241570890133 0.228274251882833 no 762 0.213236497170008 1050 6954252
SGTC_3232 9132874 49.47 µM 0.795040123947084 0.228333392400528 no 763 0.213295081251884 1037 3784940
SGTC_2305 7443522 69.23 µM 0.794836506927919 0.228393178755947 no 764 0.21335430596321 1047 5415886
SGTC_2887 9044784 58.44 µM 0.794455665876351 0.228505025525334 no 765 0.213465104366542 1107 6465546
SGTC_2529 gangaleoidin 93.61 µM 0.794226455178579 0.228572355776649 no 766 0.213531804987588 1050 4565183
SGTC_3170 9103054 49.47 µM 0.793636484731104 0.22874570983148 no 767 0.21370354303205 1006 16432970
SGTC_1311 1190-0148 100 µM 0.793397619028463 0.228815917958212 no 768 0.213773098761265 1134 1961333
SGTC_3079 9117512 49.47 µM 0.793196319580113 0.228875093889153 no 769 0.213831725742288 1098 7185044
SGTC_2438 5259590 200 µM 0.792952073671177 0.228946906308663 no 770 0.213902873134115 1072 1201127
SGTC_2640 pentamidine 10.38 µM 0.790267020255225 0.229737190314407 no 771 0.214685921464076 1094 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3173 9105693 49.47 µM 0.790029584728789 0.229807147468718 no 772 0.214755245411968 1106 17096658
SGTC_1863 st057641 20.1 µM 0.789131185012088 0.230071956669075 no 773 0.215017668476121 1104 3921635
SGTC_1616 st002734 56.1 µM 0.788360540073949 0.230299245292881 no 774 0.215242922595844 1047 4026101
SGTC_2647 atorvastatin 60.16 µM 0.787699480441013 0.230494313605023 no 775 0.215436254778559 1020 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1725 st036284 20.55 µM 0.78747289688544 0.230561196098554 no 776 0.215502544127802 1101 707914
SGTC_510 ag-490 170 µM 0.782711246651847 0.231969236988578 no 777 0.216898348164578 1166 5328779
SGTC_526 4469-0568 170 µM 0.782004302203648 0.232178691018641 no 778 0.217106022613456 1052 2901964
SGTC_912 3474-0017 2.18 µM 0.781017239221569 0.232471314773186 no 779 0.217396177756995 1090 3360550
SGTC_2936 9038235 15.59 µM 0.780340838662248 0.232671958212299 no 780 0.217595140387833 1086 4749415
SGTC_76 0433-0009 400.328 µM 0.779765078374423 0.232842824130556 no 781 0.217764582535938 949 2841569
SGTC_2338 7999974 200 µM 0.777885672668317 0.233401052219671 no 782 0.218318207677637 1141 315925
SGTC_2686 alizarin 95.37 µM 0.777160617497505 0.233616609120869 no 783 0.218532007055181 1038 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_816 0325-0417 81.3 µM 0.776967348721315 0.233674086022456 no 784 0.218589017192066 1074 68101
SGTC_2344 7990960 76.95 µM 0.776327289000134 0.23386449166473 no 785 0.218777882181357 1014 140813
SGTC_1871 st057448 67.3 µM 0.775933744571331 0.233981606344932 no 786 0.218894053518178 1109 691747
SGTC_471 1-acyl-paf 4 µM 0.775758575890699 0.234033745147697 no 787 0.218945773398147 1052 16759367
SGTC_3247 9135149 49.47 µM 0.775565023796656 0.234091363240017 no 788 0.219002929293941 1015 8934436 YOR116C RPO31
SGTC_2165 5727197 32.143 µM 0.773571743306722 0.234685195286289 no 789 0.219592043673753 1115 1361712
SGTC_689 0833-0039 98 µM 0.773361196431695 0.234747969371822 no 790 0.219654323937922 1090 5374726
SGTC_1238 0333-0287 48.8 µM 0.77299804752655 0.234856263225686 no 791 0.219761768075045 1096 7226
SGTC_3245 9134821 49.47 µM 0.771234392775514 0.235382591396139 no 792 0.220284005950292 1075 17014901
SGTC_6 0844-0013 19.835 µM 0.768736683088025 0.236129096458706 no 793 0.221024821714148 1229 1584900
SGTC_1629 st005085 44.9 µM 0.767244869419418 0.236575584867318 no 794 0.22146796997937 1079 24207091
SGTC_2300 7976697 71.57 µM 0.765349448344076 0.237143539302209 no 795 0.222031743173938 988 2236109
SGTC_295 k015-0027 31 µM 0.765178159330785 0.237194902170009 no 796 0.222082731636742 1066 3887424
SGTC_177 1327-0068 8.361 µM 0.76490060250976 0.237278143564919 no 797 0.222165367561546 1072 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1686 st019653 115.5 µM 0.761486885725863 0.238303254148115 no 798 0.223183154479866 1106 97252
SGTC_3062 9077494 49.47 µM 0.76116844612066 0.238399002437681 no 799 0.223278231223385 1057 16459633
SGTC_1648 st011736 69.8 µM 0.761014395617659 0.238445329839243 no 800 0.223324234465793 1097 2855514
SGTC_208 k072-0098 12.366 µM 0.760929492099583 0.238470864867428 no 801 0.223349591035268 1138 5948901
SGTC_1199 1638-0010 4.46 µM 0.758769209256927 0.239121080849576 no 802 0.223995313832044 1074 3111136
SGTC_1842 st055362 61.2 µM 0.758305147943262 0.239260883366856 no 803 0.224134163083448 1108 676032
SGTC_2418 pentamidine 31.67 µM 0.75738718751897 0.239537558435665 no 804 0.224408964942044 1117 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1782 st039423 80.636 µM 0.757385150427426 0.239538172613223 no 805 0.224409574981062 1047 2068169
SGTC_140 0062-0056 502.533 µM 0.757371824723879 0.239542190297794 no 806 0.224413565595238 1131 3758964
SGTC_412 gemfibrozil 100 µM 0.756724495896987 0.239737403502297 no 807 0.224607467987433 1086 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2179 6298986 200 µM 0.756529908133719 0.239796101772806 no 808 0.224665773835081 1035 738374
SGTC_1236 0330-0013 258 µM 0.752285992525407 0.241078246240328 no 809 0.225939544846713 1080 4617066
SGTC_843 0310-0051 143 µM 0.752001756232421 0.241164250858342 no 810 0.226025001320793 1124 2065037
SGTC_65 0798-0905 34.986 µM 0.749391130402947 0.241954957229253 no 811 0.226810747663255 1163 3602145
SGTC_1677 st019204 53.9 µM 0.749073668497739 0.242051205902948 no 812 0.22690640235045 1037 3945625
SGTC_1401 3807-4679 7.6 µM 0.748745829183939 0.242150622606417 no 813 0.227005207739694 1073 3291456
SGTC_1600 coumarin 106 71.1 µM 0.74726454937735 0.242600093997431 no 814 0.22745194349671 1113 100336 A hepatotoxic, DNA x-linker.
SGTC_3239 9133757 49.47 µM 0.746447443615743 0.242848225274274 no 815 0.227698584302933 1118 17036923
SGTC_215 1287-0124 461.5 µM 0.745818905885675 0.243039187330856 no 816 0.227888408840771 1117 5560863
SGTC_755 1995-0008 37.3 µM 0.745605233901043 0.24310412355207 no 817 0.227952960142117 1144 689533
SGTC_866 0495-0101 262 µM 0.744877793575634 0.243325267435452 no 818 0.228172800353122 1062 635694
SGTC_378 3970-0959 8.33 µM 0.742032658889191 0.244191239485162 no 819 0.229033774232242 1097 6615653
SGTC_695 3505-6186 243 µM 0.741658091828475 0.24430536990584 no 820 0.229147258593137 1139 1819379
SGTC_3104 9120930 49.47 µM 0.740662398434715 0.24460889699941 no 821 0.229449081838657 1081 17014836
SGTC_1378 2093-0007 380 nM 0.739823806218242 0.244864690855063 no 822 0.229703455954758 1123 3618014
SGTC_1152 3909-8331 15.9 µM 0.739235276771283 0.245044294571739 no 823 0.229882071633526 1110 16001939
SGTC_707 0865-0008 204 µM 0.738398575274428 0.245299755813695 no 824 0.230136140053509 1148 723043
SGTC_1145 3546-0597 10.2 µM 0.736826882933029 0.245780010835708 no 825 0.230613816394885 1100 875334
SGTC_643 k048-0106 28.4 µM 0.7366269290509 0.24584114602589 no 826 0.230674627045586 1125 6763920
SGTC_2284 7945075 39.21 µM 0.736463620081347 0.245891083218989 no 827 0.230724299767166 1213 1245402
SGTC_287 k060-0039 29.6 µM 0.735826531956373 0.24608594630715 no 828 0.230918136197796 1152 5861974
SGTC_2674 ligustilide 100 µM 0.735276021801256 0.246254394897051 no 829 0.231085704161699 1083 5319022 A signalling regulator.
SGTC_615 k087-0205 167 µM 0.734966320591601 0.246349186403177 no 830 0.231180002907518 1124 9642773
SGTC_2836 9010338 19.48 µM 0.733340284015776 0.246847194770177 no 831 0.231675455495792 1088 2994051
SGTC_1879 gemcitabine 100 µM 0.732262328091296 0.247177638558962 no 832 0.232004234048331 1144 60750 A nucleoside analog which inhibits DNA replication.
SGTC_688 0527-0193 473 µM 0.732009810973092 0.247255081023599 no 833 0.232081289775896 1104 4007154
SGTC_483 fpl-64176 144 µM 0.730665365854371 0.247667616510515 no 834 0.232491787651373 1148 3423
SGTC_1564 D-Arginine 115 µM 0.730406587914223 0.247747063244697 no 835 0.232570846332731 1126 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_720 r052-1644 49.9 µM 0.72898004259233 0.248185267331658 no 836 0.233006935267568 1104 1422863 YOR257W CDC31
SGTC_61 0978-8327 98.565 µM 0.728808780967674 0.248237903002098 no 837 0.233059319743704 1190 6150059 YHR072W ERG7
SGTC_2132 5317594 122.667 µM 0.726319167539899 0.249003734326782 no 838 0.233821565794176 1113 794577
SGTC_1829 berberine 14.4 µM 0.724344501050109 0.249612055396122 no 839 0.23442713148785 1146 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2665 lovastatin 100 µM 0.722516194851023 0.250175991387957 no 840 0.234988586083999 1160 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2323 6148992 148.28 µM 0.721935859134094 0.250355135517336 no 841 0.235166956611414 1107 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1107 amlodipine 47 µM 0.720008907266687 0.250950454701627 no 842 0.235759755674767 1077 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_121 0557-0495 61.343 µM 0.719934909745353 0.250973330679839 no 843 0.235782536365725 1295 3104427
SGTC_1461 k072-0203 53.8 µM 0.719069963887516 0.251240806352236 no 844 0.236048906410111 1121 5418714
SGTC_1657 st012939 43.4 µM 0.71893248648914 0.251283333712871 no 845 0.236091259425223 1155 24207257
SGTC_2838 9002687 71.43 µM 0.71881300494409 0.251320297314013 no 846 0.23612807181175 1139 6457060
SGTC_2934 9036370 36.88 µM 0.718392790714577 0.251450320397328 no 847 0.236257565359084 1161 6462800
SGTC_1501 4491-0275 38.4 µM 0.718208279695695 0.251507423200725 no 848 0.236314436772889 1149 5104718
SGTC_1746 st038117 42 µM 0.71728401031806 0.25179357085786 no 849 0.236599435652363 1149 2898218
SGTC_2998 9066762 71.4286 µM 0.716857867548877 0.251925559698283 no 850 0.236730900635265 1187 4945196
SGTC_3350 9150499 3.57 µM 0.716654997605544 0.251988407262027 no 851 0.23679350009669 1160 4910996 YPR165W RHO1
SGTC_627 1391-0720 175 µM 0.71639182742816 0.252069947704943 no 852 0.236874719928403 1111 997839
SGTC_811 0416-0114 265 µM 0.716124110826037 0.25215291108918 no 853 0.236957358595233 1182 6612453
SGTC_3109 9122853 49.47 µM 0.715753852850306 0.252267675011216 no 854 0.237071675807222 1195 1234709
SGTC_2388 9080168 200 µM 0.711367098100628 0.253629472228301 no 855 0.238428391047647 1151 15943073
SGTC_2956 9076196 2.52 µM 0.711347559474305 0.253635546304961 no 856 0.238434443358665 1182 16423868
SGTC_126 0417-1624 672.48 µM 0.710997648942429 0.253744337787502 no 857 0.238542846354598 1275 41912 YDL195W SEC31
SGTC_1435 4092-0789 56.7 µM 0.710530468007591 0.253889628265104 no 858 0.238687622005967 1180 2248285
SGTC_787 4152-0075 138 µM 0.709887889814848 0.254089537548302 no 859 0.238886830389345 1131 9566539
SGTC_3138 9097216 49.47 µM 0.707049018873808 0.254973711682643 no 860 0.239768008011865 1205 25237486
SGTC_130 0136-0219 337.655 µM 0.70672696580615 0.25507411756905 no 861 0.239868084270942 1147 234244
SGTC_2817 7995342 71.43 µM 0.706166257945344 0.255248977754682 no 862 0.240042375577537 1152 18879975
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.704818126215516 0.255669657253176 no 863 0.240461713386332 1198 165506
SGTC_638 3970-0837 4.09 µM 0.70436094411789 0.255812401393196 no 864 0.240604010899716 1185 4118451 YLR208W SEC13
SGTC_1660 st012960 28.1 µM 0.703368657960466 0.256122362006159 no 865 0.240913016730897 1164 24207266
SGTC_2516 gossypol 71.55 µM 0.702237828848826 0.25647583795582 no 866 0.241265428965054 1210 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1257 0669-0121 16 µM 0.701178114486204 0.256807315305618 no 867 0.241595933072061 1226 4307855
SGTC_1090 efavirenz 20.7 µM 0.700829529876081 0.256916400860933 no 868 0.241704703475403 1202 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_737 1950-0117 57.9 µM 0.700541547433016 0.257006539847047 no 869 0.241794583962767 1164 5393513
SGTC_2153 5569715 200 µM 0.700153733654459 0.257127952196969 no 870 0.241915650867811 1186 2054701
SGTC_911 3456-4043 236 µM 0.699481186564118 0.257338576320647 no 871 0.242125683172403 1227 914281
SGTC_2681 menadione 3.18 µM 0.698169156087478 0.257749727811126 no 872 0.242535706608157 1208 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3070 9117005 49.47 µM 0.697584948234612 0.257932910903625 no 873 0.242718398686109 1206 8779016
SGTC_1816 st051957 91.6 µM 0.696959533517149 0.258129089570717 no 874 0.242914059407718 1189 674121
SGTC_954 1189-0853 2.85 µM 0.696731960557342 0.258200493332251 no 875 0.242985276678597 1179 2828194
SGTC_773 4358-1457 44.6 µM 0.696722836650127 0.25820335628168 no 876 0.242988132173197 1226 1186886
SGTC_2317 5986382 200 µM 0.693636092559408 0.259172875391793 no 877 0.243955226599788 1239 877883
SGTC_460 trequinsin 123 µM 0.693571543430209 0.259193169773423 no 878 0.243975472351214 1237 5537 A vasodilator.
SGTC_2136 5328288 199.296 µM 0.693408078763817 0.259244567081245 no 879 0.244026746887818 1158 262395
SGTC_3216 9129716 49.47 µM 0.691221229691196 0.259932672418713 no 880 0.244713262234526 1161 8056934
SGTC_1017 4239-0030 168 µM 0.688682161608857 0.260732785815573 no 881 0.245511652115555 1191 1149593
SGTC_2713 st079149 53.4 µM 0.686217819720709 0.261510561583438 no 882 0.246287881175402 1229 3103253
SGTC_539 4859-0462 2.54 µM 0.685850696948745 0.261626531779699 no 883 0.246403631590908 1209 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3211 9128781 49.47 µM 0.685759439402362 0.261655363167662 no 884 0.246432408775167 1172 17194361
SGTC_2835 9006588 71.43 µM 0.685462139794278 0.261749301614788 no 885 0.246526171819919 1209 2345538
SGTC_2453 5731132 22.18 µM 0.684718216879829 0.261984436456567 no 886 0.246760875691405 1253 1362040
SGTC_355 1311-2252 105 µM 0.683068595919403 0.262506225119512 no 887 0.247281749149925 1189 5338538
SGTC_2776 terbinafine 19.92 µM 0.682381373878266 0.262723755960668 no 888 0.247498915184611 1223 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2409 alverine citrate 63.97 µM 0.68202182123586 0.262837604218903 no 889 0.2476125764368 1272 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_95 0471-0001 561.058 µM 0.680562085606243 0.26330007190794 no 890 0.248074312150451 1160 4015405
SGTC_1316 1272-0050 65.9 µM 0.679380612177514 0.263674685707264 no 891 0.248448365534304 1219 7340392
SGTC_3191 9110352 49.47 µM 0.678709475716067 0.263887606250031 no 892 0.248660980500059 1214 17122424
SGTC_3198 9112019 49.47 µM 0.67868911852324 0.26389406601468 no 893 0.248667431140404 1253 45595555
SGTC_544 k015-0020 52.4 µM 0.676668722789819 0.264535580753547 no 894 0.249308082683064 1223 3008304
SGTC_2356 9061756 188.97 µM 0.67529347590007 0.264972701668906 no 895 0.249744664043573 1199 20104043
SGTC_3346 9158254 43.5805 µM 0.674490759476595 0.26522801384837 no 896 0.249999679274407 1202 17639500
SGTC_1063 disulfiram 1.84 µM 0.673900698616204 0.265415768369894 no 897 0.250187223971807 1235 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2565 isoliquiritigenin 100 µM 0.673742435472348 0.265466138408043 no 898 0.250237538950969 1185 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3023 9089636 49.47 µM 0.673252285964702 0.265622167902531 no 899 0.250393401196565 1307 17249241
SGTC_964 1287-0107 19.4 µM 0.670402104623577 0.266530387873992 no 900 0.25130074668469 1250 51516812 YPR165W RHO1
SGTC_364 0083-0097 67.7 µM 0.667687615066792 0.26739682697549 no 901 0.252166508638894 1279 5207356
SGTC_2854 9024559 71.43 µM 0.66767792505473 0.267399922477693 no 902 0.252169601996165 1219 3163529
SGTC_1148 3909-7663 27.7 µM 0.667456428659749 0.267470685066154 no 903 0.252240316083753 1292 4084526
SGTC_2036 5160441 105 µM 0.66505189344738 0.268239481475604 no 904 0.253008651159265 1264 134534 YIL048W NEO1
SGTC_168 3970-0862 530.542 µM 0.664939133766806 0.268275561136338 no 905 0.253044712117234 1253 3135186
SGTC_938 3126-1755 342 µM 0.664821786429757 0.268313111299497 no 906 0.253082243095649 1260 1777771
SGTC_1596 piperlongumine 63 µM 0.664499999689352 0.268416093919084 no 907 0.253185174567221 1259 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_315 k915-0449 187 µM 0.663955271114803 0.268590470741705 no 908 0.253359469682322 1281 20970215 YNL149C PGA2
SGTC_1242 0402-0103 60.1 µM 0.660499731543121 0.269697971827489 no 909 0.254466595354157 1217 432868
SGTC_1887 st057648 70.8 µM 0.660373128420426 0.269738591547189 no 910 0.254507206010458 1241 688672
SGTC_996 3970-0799 1.8 µM 0.660182990742463 0.269799601636747 no 911 0.254568203111465 1351 6615648 YGL040C HEM2
SGTC_1290 0986-0249 10.2 µM 0.659929276314835 0.269881022562992 no 912 0.254649607871584 1206 53329
SGTC_2471 5466956 24.79 µM 0.658946813001078 0.270196426391178 no 913 0.254964961670611 1218 724419
SGTC_2690 usnic acid 100 µM 0.658190523766598 0.270439346226267 no 914 0.255207856608654 1319 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1139 k015-0024 46.9 µM 0.657258898771633 0.270738733797383 no 915 0.255507229796842 1244 2766652
SGTC_1255 0566-0045 221 µM 0.653950860722047 0.271803142083962 no 916 0.25657173235343 1299 2788469
SGTC_1393 3470-5649 58.2 µM 0.65292052390163 0.272135092403374 no 917 0.256903758386046 1207 4108395
SGTC_1860 st056228 74.6 µM 0.652759524250854 0.272186980908916 no 918 0.256955660712431 1237 688679
SGTC_2293 7624732 200 µM 0.652261567501699 0.272347498285588 no 919 0.257116224240663 1241 894453
SGTC_174 3553-0389 74.3 µM 0.651827179873062 0.272487562420115 no 920 0.257256332838209 1255 738071
SGTC_375 3970-0961 9.27 µM 0.65153564846261 0.272581583988013 no 921 0.257350386443286 1236 2898222
SGTC_1487 3970-0795 2.82 µM 0.650805197965171 0.272817231713108 no 922 0.257586122189335 1304 3765103
SGTC_1116 jasmonic acid 1.58368 µM 0.649244208494073 0.27332115479426 no 923 0.258090270517295 1313 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.647448609856033 0.273901384630502 no 924 0.258670822069755 1312 364106
SGTC_2768 sulfasalazine 50.2 µM 0.645569130406889 0.274509371272028 no 925 0.259279217257267 1338 5384001 An antioxidant and salicylic acid derivative.
SGTC_771 0250-0039 27.3 µM 0.644414311122141 0.274883269960824 no 926 0.259653403415068 1273 3005115
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.644402585173276 0.27488706778703 no 927 0.259657204302524 1298 4213774
SGTC_1917 st066507 28.5 µM 0.643345551993697 0.275229528220509 no 928 0.259999952447809 1278 3156428
SGTC_1772 st048439 82.2 µM 0.640602511731373 0.27611920426923 no 929 0.260890483633671 1254 2927068 YDL195W SEC31
SGTC_3129 9127257 49.47 µM 0.638639488772238 0.27675675545163 no 930 0.261528743012166 1195 837894
SGTC_3154 9100113 49.47 µM 0.638424345497846 0.276826673575337 no 931 0.261598743636408 1267 25237525
SGTC_2279 7948423 32.93 µM 0.637686024559676 0.277066681842534 no 932 0.261839042364421 1318 1247112
SGTC_3167 9103034 49.47 µM 0.637033944525693 0.277278740170329 no 933 0.262051366678094 1287 5127859
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.636806163820694 0.277352833822318 no 934 0.262125555332562 1275 2374 Ca(2+)-ATPase inhibitor.
SGTC_2001 4023502 57.655 µM 0.635698997919651 0.277713116138537 no 935 0.262486314839291 1312 108941 YCR052W RSC6
SGTC_3088 9117578 49.47 µM 0.635503580982738 0.277776730393243 no 936 0.262550015974289 1343 678341
SGTC_377 3970-0964 33.1 µM 0.635320805828573 0.277836235795965 no 937 0.262609603358053 1301 16481235
SGTC_2191 5911152 200 µM 0.635278409094853 0.277850039626371 no 938 0.262623426304475 1285 2875902
SGTC_1735 st034310 56.75 µM 0.631153729066652 0.279194580680217 no 939 0.263970006506652 1381 871153
SGTC_1778 st046819 58.9 µM 0.630742807301567 0.27932870378482 no 940 0.264104352222664 1318 671715
SGTC_2170 morpholine 200 µM 0.630362075540924 0.279453000934124 no 941 0.264228858776943 1341 121171 Reacts with secondary amines.
SGTC_3267 9137951 49.47 µM 0.62680185510645 0.280616601062762 no 942 0.265394563674725 1330 16643986
SGTC_3275 9138069 49.47 µM 0.626072148982437 0.28085538278917 no 943 0.265633809523166 1320 17617007
SGTC_2821 7996764 71.43 µM 0.625838070954522 0.280932000943343 no 944 0.265710578919689 1358 2987135
SGTC_3294 9122953 26.2835 µM 0.623711830590365 0.281628421786665 no 945 0.266408426068484 1289 16459826
SGTC_2206 7254556 146.969 µM 0.620694027747489 0.282618288707311 no 946 0.267400479830918 1294 4398905
SGTC_591 4299-0174 154 µM 0.618426065021914 0.283363300154517 no 947 0.268147260285415 1309 5509088
SGTC_617 3770-0098 35 µM 0.618366307311953 0.283382942910865 no 948 0.268166951109893 1314 5962639
SGTC_2196 6573537 42.6665 µM 0.618101918557821 0.283469857083894 no 949 0.26825407885091 1359 2903087
SGTC_3203 9113543 49.47 µM 0.617902952492957 0.283535272870344 no 950 0.268319656324231 1364 17018012
SGTC_151 3013-0144 2.285 µM 0.616560026235648 0.283976987381572 no 951 0.268762483845018 1359 906558 YHR107C CDC12
SGTC_1834 st055981 52.8 µM 0.615495736925965 0.284327286507403 no 952 0.269113691901935 1393 471719 YDL150W RPC53
SGTC_621 3584-0052 32.1 µM 0.614447645123384 0.284672456103372 no 953 0.269459779808111 1328 2273927
SGTC_2195 6536160 144.242 µM 0.613757920726191 0.284899713122313 no 954 0.269687653714517 1222 3834386
SGTC_1299 1079-1439 3.74 µM 0.613330661741744 0.285040533911864 no 955 0.269828861648579 1283 323161
SGTC_2507 purpurin 79.67 µM 0.612511403163703 0.285310647097525 no 956 0.270099727886346 1294 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1614 st002383 48.6 µM 0.611857629923846 0.285526286472297 no 957 0.270315978304139 1325 1947235
SGTC_2809 7964133 12.99 µM 0.610379854635743 0.286013998856787 no 958 0.270805104929407 1344 1253665
SGTC_35 0133-0054 64.071 µM 0.60751301669909 0.286961273058299 no 959 0.271755253447974 1268 99677
SGTC_1389 3405-0187 19 µM 0.605279768716169 0.287700221753963 no 960 0.272496560816957 1284 799890
SGTC_445 e6 berbamine 66 µM 0.604769518079543 0.287869182240164 no 961 0.27266607491535 1360 6610268 A calcium/calmodulin antagonist.
SGTC_897 1000-0139 31.4 µM 0.603786735984084 0.28819474515884 no 962 0.272992719550216 1337 6151020
SGTC_1883 5-benzylidenerhodanine 20 µM 0.603137241137011 0.288409996411535 no 963 0.273208696820547 1343 1273210
SGTC_927 2425-1185 123 µM 0.602732449281038 0.28854418815387 no 964 0.273343345531756 1305 730375
SGTC_1066 ketoconazole 628 nM 0.602208040229041 0.288718077685138 no 965 0.273517832188829 1392 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2961 9083290 32.55 µM 0.601637469962921 0.288907329912812 no 966 0.273707740671158 1353 17741490
SGTC_2517 totarol 10 µM 0.601465683687356 0.288964321067177 no 967 0.273764930749996 1284 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_221 trifluoperazine 10.304 µM 0.601033076217488 0.289107864686068 no 968 0.273908978066742 1326 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.59992058728884 0.289477153893686 no 969 0.274279580649629 1345 2724 A muscle relaxant with antifungal properties.
SGTC_1920 st075728 45.7 µM 0.599898899333442 0.289484355382507 no 970 0.274286808001304 1419 3400306
SGTC_640 3381-0960 37.1 µM 0.59942177659956 0.289642805340088 no 971 0.274445829429518 1401 1745025
SGTC_1424 4048-1941 275 µM 0.599237348343357 0.289704063904391 no 972 0.274507310174511 1414 X1424
SGTC_2641 levomentholum 100 µM 0.598316585087696 0.290009989927253 no 973 0.274814356142123 1300 16666
SGTC_983 1491-0821 12.2 µM 0.597778045537842 0.290188991282355 no 974 0.274994020800038 1340 46495113
SGTC_1736 st036774 51 µM 0.59734152670898 0.29033412066388 no 975 0.275139692305338 1365 1272247
SGTC_529 4076-0302 30.3 µM 0.596598890119289 0.290581103063808 no 976 0.275387606215654 1329 5816522
SGTC_620 0109-0052 432 µM 0.596167369755853 0.290724661111465 no 977 0.275531710861739 1355 493037
SGTC_160 3453-0671 289.699 µM 0.59562330229227 0.290905708547073 no 978 0.275713453041165 1286 5322268
SGTC_1440 4100-1550 40 µM 0.595222700547186 0.29103904906905 no 979 0.275847309090867 1354 742806
SGTC_2232 chlorophetanol 41.5365 µM 0.594117185032579 0.291407168579772 no 980 0.276216868791105 1404 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2972 9093619 59.92 µM 0.593111046371655 0.291742385839466 no 981 0.276553419137389 1308 25236256
SGTC_1021 4476-0760 85.3 µM 0.593031544252011 0.291768881380849 no 982 0.276580020923736 1310 746768
SGTC_850 0388-0143 75.9 µM 0.592919956782782 0.291806071845401 no 983 0.27661736073587 1337 67273
SGTC_2939 9044578 71.43 µM 0.590979669930279 0.292453093745734 no 984 0.277267021403889 1320 2653634
SGTC_1987 st072290 61.9 µM 0.590764371127965 0.292524929907271 no 985 0.277339155254881 1387 54697379
SGTC_1788 fluconazole 20 µM 0.590125253870665 0.292738224762403 no 986 0.277553339554209 1341 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1723 st034307 2.5525 µM 0.589137089102998 0.293068150557995 no 987 0.277884657486138 1371 867466
SGTC_1356 1502-0781 85.8 µM 0.587911974165818 0.293477427943109 no 988 0.278295689378551 1331 567702
SGTC_764 1951-2361 146 µM 0.58638827322716 0.293986823807129 no 989 0.278807311471112 1317 5438930
SGTC_1240 0356-0016 42.1 µM 0.585551191503151 0.29426684653557 no 990 0.279088578047183 1381 4305613
SGTC_2028 5153890 36.43 µM 0.584960241568584 0.294464606781942 no 991 0.279287225295667 1325 2830968 YPR165W RHO1
SGTC_2662 daunorubicin 22.37 µM 0.584354007471727 0.294667545565138 no 992 0.27949108166827 1321 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2851 9015922 71.43 µM 0.582073926074918 0.295431386981133 no 993 0.28025844353112 1414 2996893
SGTC_2048 5246248 200 µM 0.581637758827837 0.29557760943268 no 994 0.280405351909315 1361 677046
SGTC_949 1165-0505 146 µM 0.579236597228138 0.296383179570773 no 995 0.281214769971568 1355 6244267
SGTC_505 gw-5074 63.9 µM 0.578959412892529 0.296476237418731 no 996 0.281308279839612 1429 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1027 k015-0025 8.67 µM 0.578371252200902 0.296673742294531 no 997 0.281506749227155 1344 3598955
SGTC_1425 4048-4433 7.33 µM 0.57804368984691 0.296783764136706 no 998 0.281617311393582 1407 23734946
SGTC_3353 9151644 39.2805 µM 0.576626708294341 0.297259915773274 no 999 0.282095826445055 1362 4909158
SGTC_3051 9093778 49.47 µM 0.575497329843732 0.297639673289133 no 1000 0.282477497995455 1375 17217378
SGTC_2431 5490079 200 µM 0.575303626079236 0.297704829105317 no 1001 0.282542984796765 1366 5722345
SGTC_601 0986-0029 62.9 µM 0.575252800008199 0.29772192646485 no 1002 0.28256016913477 1374 24747981
SGTC_2649 anisomycin 9.56 µM 0.574995681058451 0.297808425459001 no 1003 0.282647108970512 1337 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2080 5212524 12.4 µM 0.574707811223187 0.297905283148771 no 1004 0.282744461879833 1381 260183
SGTC_26 0302-0163 425.158 µM 0.573963320560191 0.298155843654652 no 1005 0.282996311229744 1379 3100915
SGTC_3089 9117425 49.47 µM 0.573421487741162 0.298338259404891 no 1006 0.283179672337178 1301 9401657
SGTC_680 0417-1641 114 µM 0.57322424869738 0.298404675354158 no 1007 0.283246433954436 1357 2835990
SGTC_2938 9059746 27.26 µM 0.57181583087577 0.298879124808027 no 1008 0.283723375555738 1391 6471769
SGTC_663 1486-0733 13.9 µM 0.571175360482264 0.299094991434352 no 1009 0.283940389311812 1375 722445 YPR165W RHO1
SGTC_3155 9099265 49.47 µM 0.571007939961482 0.299151431163038 no 1010 0.28399713032951 1369 25236499
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.569848957559397 0.299542272336934 no 1011 0.284390073415092 1406 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_958 1222-0007 33 µM 0.569620394072427 0.29961937762894 no 1012 0.284467596571103 1462 7312461
SGTC_856 0433-0016 11.3 µM 0.568046960824784 0.300150415062206 no 1013 0.285001540490438 1386 3911780
SGTC_1897 st060201 15 µM 0.567248906973219 0.300419922707015 no 1014 0.285272542283878 1359 611878
SGTC_1360 1598-0022 39.8 µM 0.566424387143697 0.300698482840494 no 1015 0.285552660229101 1461 761525
SGTC_2905 7799065 20.05 µM 0.566005712945701 0.300839974552026 no 1016 0.285694948456018 1390 1296806
SGTC_1929 genistein trimethyl ether 50.5 µM 0.565883827333722 0.30088117166109 no 1017 0.285736378143928 1432 136420
SGTC_2372 9071633 200 µM 0.565765382486553 0.300921208235557 no 1018 0.285776641031959 1418 21321366
SGTC_1678 st019265 80.2 µM 0.565453323888256 0.301026701381046 no 1019 0.285882731847645 1466 5367020
SGTC_133 0724-0033 378.92 µM 0.564396035200191 0.301384247562539 no 1020 0.286242318274618 1283 280309
SGTC_2281 7943571 200 µM 0.563133300673499 0.301811520243931 no 1021 0.286672058555682 1446 1244024
SGTC_2987 9018338 71.43 µM 0.562637716170486 0.301979286006163 no 1022 0.286840801968212 1415 5055682
SGTC_1621 st003705 32.4 µM 0.561051279910851 0.302516609438822 no 1023 0.287381289845722 1450 24207032
SGTC_248 streptozotocin 5.23457 mM 0.561008097799335 0.302531241141465 no 1024 0.287396008425632 1445 5300 DNA alkylating agent.
SGTC_846 0335-0850 148 µM 0.560174760695774 0.302813668800624 no 1025 0.287680120366399 1369 6819598
SGTC_2109 5483026 200 µM 0.55997099983996 0.302882743689505 no 1026 0.287749609311788 1436 759335
SGTC_2436 5633522 8.09 µM 0.558168956221222 0.303493942900351 no 1027 0.288364508539637 1420 5724242
SGTC_100 0086-0128 49.5915 µM 0.556387789988307 0.304098601885104 no 1028 0.288972892014795 1319 93297
SGTC_2240 6690706 185.951 µM 0.556062982847661 0.304208923199394 no 1029 0.289083899731227 1321 805876
SGTC_2642 cholecalciferol 100 µM 0.554563254210817 0.304718539691725 no 1030 0.289596714412143 1432 9821465 A vitamin D precursor, similar to steriods.
SGTC_2120 5538279 151.968 µM 0.55422713023564 0.304832808617349 no 1031 0.289711706636823 1441 2058197
SGTC_2244 6635614 200 µM 0.550225877602766 0.30619453691147 no 1032 0.29108222826469 1403 836499
SGTC_282 k297-0036 65.7 µM 0.550024357443339 0.306263190449858 no 1033 0.291151333608782 1432 5061378
SGTC_624 k048-0052 28 µM 0.549213014933577 0.306539666022708 no 1034 0.291429636871629 1393 6835531
SGTC_1208 2323-2347 50.3 µM 0.548395655722216 0.306818303242792 no 1035 0.291710129380294 1426 5412760
SGTC_370 0180-0345 38.7 µM 0.547027748549893 0.307284871639353 no 1036 0.292179834267194 1395 3989527
SGTC_1845 st056753 3.01 µM 0.545158530774816 0.307922932558388 no 1037 0.292822244972006 1351 5375839
SGTC_200 k038-0079 37.545 µM 0.544070104970775 0.308294736571848 no 1038 0.293196615779198 1437 3436683
SGTC_2880 9042983 58.44 µM 0.543653343394164 0.308437153581148 no 1039 0.293340022238879 1413 6464714
SGTC_990 3985-0011 41.3 µM 0.542643575388994 0.308782334036197 no 1040 0.293687615219023 1420 5399565 YGL099W LSG1
SGTC_384 k007-0144 5.16 µM 0.540523055920687 0.309507765080501 no 1041 0.294418182595541 1448 6824886
SGTC_3223 9129970 49.47 µM 0.540347016403794 0.309568021743008 no 1042 0.294478869925818 1476 17248386
SGTC_2663 amphotericin b 100 µM 0.54021327267551 0.30961380437908 no 1043 0.294524980193076 1401 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_857 0438-0306 1.35 µM 0.538219097517039 0.310296792815835 no 1044 0.295212898500427 1444 4686136
SGTC_2896 9052656 71.43 µM 0.537561024159952 0.310522321282228 no 1045 0.295440072219087 1390 6469436
SGTC_2883 9059145 45.46 µM 0.537088261639433 0.310684385810868 no 1046 0.295603324340977 1404 16476510
SGTC_1509 1326-1131 80 µM 0.53678947430203 0.310786830032336 no 1047 0.295706521555783 1402 768313
SGTC_3041 9091929 49.47 µM 0.536519769333627 0.310879315476452 no 1048 0.295799688317581 1469 25236887
SGTC_3124 9127567 49.47 µM 0.535020088375472 0.311393793953233 no 1049 0.296317983205282 1519 17592030
SGTC_3102 9121669 49.47 µM 0.532821312276368 0.312148769205855 no 1050 0.297078639671372 1473 41905072
SGTC_2670 beta-carotene 100 µM 0.529749151725905 0.313204953148609 no 1051 0.298142932174517 1390 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1104 tacrolimus 29.8 µM 0.529527332399397 0.313281272325696 no 1052 0.298219844514961 1455 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2442 5158906 48.48 µM 0.527806641153704 0.313873564942538 no 1053 0.298816773624922 1550 1893835
SGTC_904 1141-0088 396 µM 0.527194054827275 0.314084544004629 no 1054 0.29902941839355 1356 1378119
SGTC_1076 itraconazole 331 nM 0.52672517835136 0.314246069444143 no 1055 0.299192224115098 1442 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2482 5981709 142.65 µM 0.526546335706383 0.314307689154726 no 1056 0.299254333381575 1477 877755
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.526209319274466 0.314423821244841 no 1057 0.299371389836985 1502 688798
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.52557870206735 0.314641174208433 no 1058 0.299590478879326 1505 6710655
SGTC_1187 1391-0724 117 µM 0.525126241413134 0.314797162070666 no 1059 0.299747717520406 1467 6997986
SGTC_1519 esterone 74 µM 0.524116659329324 0.315145339189445 no 1060 0.300098701067756 1382 698 A steroid.
SGTC_2553 4-methylesculetin 85.09 µM 0.524048961104107 0.315168692327876 no 1061 0.300122243161332 1421 5319502
SGTC_2370 9071495 200 µM 0.523900909429013 0.315219766717379 no 1062 0.300173731120028 1403 21791103
SGTC_1786 berberine 21.6 µM 0.523293652509702 0.315429293197466 no 1063 0.300384958748867 1402 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1970 st070122 35.8 µM 0.521540808077024 0.316034423261099 no 1064 0.300995042735054 1495 102928
SGTC_690 glyoxal 20.3 µM 0.520231503278875 0.316486753173706 no 1065 0.301451115244152 1356 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_775 4577-0580 57.3 µM 0.518290631514007 0.317157777823584 no 1066 0.302127754205399 1503 2006902
SGTC_2105 5350118 200 µM 0.517405530349191 0.317463986943645 no 1067 0.302436549961372 1434 2133313
SGTC_2557 derrustone 83.84 µM 0.516461960471016 0.317790561478012 no 1068 0.302765900159225 1419 629853 An antioxidant.
SGTC_1745 st081495 74 µM 0.515804278293703 0.318018272641705 no 1069 0.302995557082307 1454 13842402 YBL026W LSM2
SGTC_1857 st056007 79.3 µM 0.512562504987419 0.319141685241955 no 1070 0.304128693480325 1462 619834
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.512291142836483 0.319235799358177 no 1071 0.304223631582071 1387 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1386 3228-0095 33.8 µM 0.511762626709217 0.319419133333144 no 1072 0.304408574830517 1536 870181
SGTC_1931 st074438 57.1 µM 0.510861903145891 0.319731681973111 no 1073 0.304723879610097 1428 2787313
SGTC_1876 myriocin 605 nM 0.510851460402216 0.319735306328239 no 1074 0.304727536019192 1556 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_32 0928-0142 34.1 µM 0.510114002775847 0.319991298699176 no 1075 0.304985797811984 1453 2244242
SGTC_2497 7-hydroxyflavone 100 µM 0.509787451840831 0.320104681146829 no 1076 0.305100188826455 1499 5281894
SGTC_762 1165-0429 115 µM 0.509730662832223 0.320124400695186 no 1077 0.305120083998968 1562 5967793
SGTC_2541 muurolladie-3-one 83.07 µM 0.508393099499015 0.320589006142701 no 1078 0.305588845560565 1486 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.507800788410977 0.320794836540869 no 1079 0.305796528416937 1441 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1416 3966-0321 25.3 µM 0.50588500553966 0.321460955580034 no 1080 0.306468689568206 1472 582530 YLR208W SEC13
SGTC_2319 6033012 152.6 µM 0.505099528961915 0.321734232539803 no 1081 0.306744466100044 1414 847246
SGTC_398 bronopol 33.3 µM 0.503067728451001 0.322441568150947 no 1082 0.307458327493188 1498 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1101 ebselen 5.29 µM 0.502405022283996 0.322672416894402 no 1083 0.307691323479314 1571 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2771 fluoxetine 41.05 µM 0.502232572838007 0.322732499584031 no 1084 0.307751966436444 1517 3386 A selective serotonin reuptake inhibitor.
SGTC_2927 9011802 47.9 µM 0.502042506139503 0.322798725619001 no 1085 0.307818810698497 1412 43912568
SGTC_2107 5363541 170.161 µM 0.499433354172698 0.323708414849731 no 1086 0.30873706332727 1470 244052
SGTC_3256 9138902 49.47 µM 0.497868822092488 0.324254400031692 no 1087 0.309288251909062 1530 17228773
SGTC_1453 4237-0541 195 µM 0.497499518682238 0.324383333507488 no 1088 0.309418421123293 1520 739892
SGTC_2236 dapsone 200 µM 0.496687109160786 0.324667041006532 no 1089 0.309704857120141 1480 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3290 9121031 71.43 µM 0.494952065420101 0.325273288949237 no 1090 0.310316978590294 1455 17014854
SGTC_2621 lithochol-11-enic acid 100 µM 0.492360424435646 0.326179705143257 no 1091 0.311232285610182 1593 6708711
SGTC_781 4335-2806 94.4 µM 0.491010721354792 0.326652165842271 no 1092 0.31170943229792 1625 845254
SGTC_1603 st002045 67.8 µM 0.490986353549507 0.32666069829912 no 1093 0.311718049707187 1508 5887985
SGTC_3110 9122132 49.47 µM 0.489835347836073 0.327063829465356 no 1094 0.31212520773965 1573 918317
SGTC_2603 homopterocarpin 100 µM 0.489793334477564 0.327078548152274 no 1095 0.312140073937719 1505 101795 A weak amylase inhibitor.
SGTC_309 k408-0051 1.48 µM 0.48960939544316 0.327142991324134 no 1096 0.312205163364451 1482 3640463
SGTC_2991 9074669 71.4286 µM 0.489503384110485 0.327180134811348 no 1097 0.312242679635649 1587 17333109
SGTC_2451 5856223 45.7 µM 0.488611176066007 0.327492808029382 no 1098 0.312558499584494 1448 2179896
SGTC_838 0109-0203 71.4 µM 0.488256629684044 0.327617091994235 no 1099 0.312684038626161 1480 759422
SGTC_667 1498-1044 59 µM 0.48821017692755 0.327633377126354 no 1100 0.312700488393695 1540 6739982
SGTC_1466 k213-0079 57.5 µM 0.486576994368415 0.328206136819299 no 1101 0.313279065028151 1491 3657981
SGTC_3178 9107506 49.47 µM 0.48597227590453 0.328418315126535 no 1102 0.313493411331181 1516 8897194
SGTC_3246 9135460 32.98 µM 0.485945677037735 0.328427649174775 no 1103 0.313502840915515 1519 41446951
SGTC_3348 9149464 3.537 µM 0.482989928054653 0.329465543675758 no 1104 0.314551443854662 1488 1951442
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.48248426094702 0.329643237778295 no 1105 0.314730988243718 1526 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_301 4119-0100 24.5 µM 0.482420809505491 0.329665537668181 no 1106 0.314753520686122 1521 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2849 9019321 12.99 µM 0.482190476237096 0.329746492951309 no 1107 0.314835320858564 1504 16489627
SGTC_774 k060-0086 136 µM 0.481954831040399 0.329829323474019 no 1108 0.314919016902643 1571 5911235
SGTC_1056 3448-1962 115 µM 0.481936707056777 0.329835694495001 no 1109 0.314925454540805 1539 715507
SGTC_1904 st060225 78 µM 0.480932173306062 0.330188889687226 no 1110 0.315282352765985 1465 66595
SGTC_2893 9048488 25.97 µM 0.480818083189766 0.330229013478139 no 1111 0.315322898462693 1435 6467338
SGTC_2607 solasodine 47.35 µM 0.48061246981936 0.33030132956095 no 1112 0.315395975591292 1499 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3032 9089427 49.47 µM 0.480076248515963 0.330489953260575 no 1113 0.31558658818465 1475 17173707
SGTC_678 1218-2179 85.9 µM 0.479818140657939 0.330580761839067 no 1114 0.315678356249695 1537 6820081 YOR116C RPO31
SGTC_832 4083-0019 164 µM 0.47799508088114 0.331222442066327 no 1115 0.316326853104403 1639 1990758
SGTC_1820 st053765 18.6 µM 0.477886034179246 0.331260840040512 no 1116 0.316365661015743 1481 3690829
SGTC_2247 cerulenin 830 nM 0.477589717221266 0.331365189349153 no 1117 0.316471125516486 1577 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2333 9017922 200 µM 0.475863236341815 0.331973437289844 no 1118 0.317085907524227 1651 3163164
SGTC_665 3914-0008 307 µM 0.474642827406666 0.332403660929397 no 1119 0.317520787454623 1468 1069549
SGTC_2381 9035592 200 µM 0.473482804682752 0.332812801774831 no 1120 0.317934382986462 1433 4749657
SGTC_1825 st052143 62.6 µM 0.472779722740954 0.333060876251292 no 1121 0.318185171071459 1579 674173
SGTC_2014 4013930 200 µM 0.472365606093213 0.33320702680846 no 1122 0.318332924770479 1487 64556
SGTC_1652 st011932 78 µM 0.472318494300281 0.333223655165656 no 1123 0.318349735734787 1590 1551076
SGTC_2210 7115885 190.385 µM 0.46995217608745 0.334059280891132 no 1124 0.319194592887265 1516 2927039
SGTC_2304 7443016 91.4 µM 0.469065425326217 0.334372634403654 no 1125 0.319511435809111 1498 939854
SGTC_1111 tnp00062 510.699 nM 0.467461871010292 0.334939579744314 no 1126 0.32008473277811 1646 676306
SGTC_1114 scopoletin 1.73284 µM 0.467323054851946 0.334988676670059 no 1127 0.320134382066848 1625 5280460 A coumarin with genotoxic properties.
SGTC_913 3487-1245 167 µM 0.466991543389991 0.335105938070886 no 1128 0.320252964205924 1450 4016153
SGTC_264 promethazine 12.5 mM 0.466201379758902 0.335385497558196 no 1129 0.320535680915329 1535 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2368 9071271 200 µM 0.465602849322372 0.335597318018447 no 1130 0.320749901540637 1490 27209959
SGTC_1888 azatryptophan 97.5 µM 0.464758506643972 0.335896220496569 no 1131 0.321052202580371 1506 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_636 0kpi-0074 126 µM 0.464062923949771 0.336142539039262 no 1132 0.321301332044588 1518 616434
SGTC_455 paf C-16 10 µM 0.462972900100881 0.336528677918772 no 1133 0.3216918960473 1535 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2261 9010538 184.68 µM 0.462904754073774 0.336552824251322 no 1134 0.321716319849284 1466 6457250
SGTC_1518 st038567 90.8 µM 0.462645622430161 0.33664464909347 no 1135 0.321809200675813 1513 77966
SGTC_2567 aureobasidin a 60 nM 0.46256426108462 0.336673481980691 no 1136 0.321838365405455 1604 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2286 7945697 125 µM 0.461856859324719 0.336924211930889 no 1137 0.322091986376878 1472 1245733
SGTC_2720 fluspirilene 36.88 µM 0.461692366495172 0.336982524804304 no 1138 0.32215097299161 1567 3396 An atypical antipsychotic.
SGTC_1033 k072-0102 21.3 µM 0.460931060356376 0.337252459605835 no 1139 0.322424033321987 1647 5965931
SGTC_2189 6047310 154.431 µM 0.459606494526119 0.33772230794839 no 1140 0.322899348323291 1501 711535
SGTC_77 0828-0286 12.516 µM 0.458812342259853 0.338004130030196 no 1141 0.323184465435264 1473 745345
SGTC_1930 st074634 34.3 µM 0.458019640250019 0.338285528031456 no 1142 0.323469165496924 1486 684253 YOR116C RPO31
SGTC_101 0490-5701 117.494 µM 0.455840848303954 0.339059433406094 no 1143 0.324252213918545 1615 4661669
SGTC_3131 9127911 49.47 µM 0.45458249983925 0.339506707732538 no 1144 0.324704813576859 1579 45595681
SGTC_562 3772-2733 112 µM 0.452503807268211 0.340246064841247 no 1145 0.325453039546773 1573 2876874 YIL048W NEO1
SGTC_2258 7960471 200 µM 0.451650836805236 0.3405496305594 no 1146 0.325760270393818 1507 2974708
SGTC_660 4031-1742 102 µM 0.450088975172007 0.341105752969621 no 1147 0.326323142981637 1544 6738706
SGTC_2772 vinpocetine 57.06 µM 0.450062143712038 0.341115309702312 no 1148 0.326332816117461 1599 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3292 9120825 59.784 µM 0.448451416731139 0.341689199154185 no 1149 0.32691372066315 1668 24824900
SGTC_1175 0741-0056 27.6 µM 0.447747873947062 0.341939980916658 no 1150 0.327167583344183 1653 765927
SGTC_137 0438-0332 85.389 µM 0.447539751939745 0.342014180545068 no 1151 0.327242696329819 1525 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_724 3910-0327 137 µM 0.446125446326503 0.342518570073987 no 1152 0.327753316328574 1523 2885483
SGTC_2006 4011487 200 µM 0.445506544688936 0.342739379897528 no 1153 0.327976865603172 1685 45595294
SGTC_828 2074-0507 139 µM 0.445468207391326 0.342753059528954 no 1154 0.327990715187446 1644 X828
SGTC_1318 1280-3875 124 µM 0.443736996113676 0.343371010258819 no 1155 0.328616372146924 1575 373245
SGTC_2099 5377090 177.372 µM 0.441626183829712 0.344125025181315 no 1156 0.329379866664183 1539 2243829
SGTC_2428 5615643 7.78 µM 0.441354654769103 0.344222064658507 no 1157 0.329478132236989 1595 2253075
SGTC_2429 5902844 64.44 µM 0.439234008643901 0.344980296920846 no 1158 0.330245992573987 1681 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2145 5634607 200 µM 0.438894145455758 0.345101872233062 no 1159 0.330369119529272 1521 308662
SGTC_123 0083-0120 66.675 µM 0.437305514213801 0.3456703667178 no 1160 0.330944898422872 1502 16001701
SGTC_2273 7815444 169.05 µM 0.435783566855447 0.346215324885733 no 1161 0.331496883919336 1699 2824616
SGTC_3005 9076496 71.4286 µM 0.435598313246986 0.346281679744163 no 1162 0.331564097405265 1609 21368410
SGTC_844 0330-0132 15.3 µM 0.43180201757283 0.347642488247821 no 1163 0.332942656516233 1642 2828079
SGTC_1991 st073000 8.92 µM 0.429752434518144 0.348377993720736 no 1164 0.333687868320119 1655 4301969 YIL048W NEO1
SGTC_2321 7390090 138.78 µM 0.429528208967323 0.348458493106828 no 1165 0.333769434811322 1498 649046
SGTC_214 4373-3496 70 µM 0.429101945826318 0.348611544981473 no 1166 0.33392451814363 1649 3779166
SGTC_770 0389-1121 67.2 µM 0.423731328745486 0.350541995445868 no 1167 0.335880882291167 1708 6753108
SGTC_2928 9011484 9.79 µM 0.42315499776746 0.350749386283072 no 1168 0.336091089028402 1598 2994751
SGTC_439 amiodarone 34.4 µM 0.421951835237271 0.351182483727608 no 1169 0.33653008688617 1664 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3098 9119039 49.47 µM 0.421511555368892 0.351341017805107 no 1170 0.33669078752338 1597 17161528
SGTC_987 1497-1013 404 µM 0.420084538050102 0.351855029720741 no 1171 0.337211848802349 1631 1676435
SGTC_1041 0206-0046 107 µM 0.419919412185084 0.351914525593001 no 1172 0.337272163067034 1600 50494
SGTC_1604 st002052 72.4 µM 0.418578184685972 0.352397912395395 no 1173 0.337762217829634 1618 6254834 YHR062C RPP1
SGTC_603 3794-0023 45.9 µM 0.41772107685572 0.352706944396081 no 1174 0.338075530180268 1700 3802260
SGTC_2528 xanthyletin 44.79 µM 0.416951215577507 0.352984602361662 no 1175 0.338357045553348 1611 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1125 tnp00248 1.32998 µM 0.416017220310741 0.353321561964327 no 1176 0.338698701168118 1792 24207736
SGTC_1348 1493-0373 93.8 µM 0.41421843236822 0.353970838651198 no 1177 0.339357071970556 1633 3010129
SGTC_3257 9139206 32.98 µM 0.414161435763193 0.353991418662441 no 1178 0.339377941215075 1671 4910041
SGTC_2260 7964312 200 µM 0.409957762706272 0.3555104293707 no 1179 0.340918465771268 1714 231951
SGTC_571 k831-0106 44.2 µM 0.409812229710297 0.355563059475398 no 1180 0.340971847122033 1716 4783639
SGTC_216 k038-0035 28.382 µM 0.409249524267631 0.355766580442037 no 1181 0.341178276835742 1661 4444231 YPR107C YTH1
SGTC_3166 9102297 49.47 µM 0.409037840240699 0.355843153593139 no 1182 0.341255945890528 1568 25237072
SGTC_1207 2099-0101 141 µM 0.405971691190984 0.356952932526972 no 1183 0.342381700377651 1726 5837381
SGTC_1839 st053978 48 µM 0.402219722200812 0.358312588754375 no 1184 0.34376116445248 1644 3788398
SGTC_1462 k081-0014 26.5 µM 0.401964871861174 0.358405008043964 no 1185 0.343854939502216 1516 3270634
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.401353217123355 0.358626853222367 no 1186 0.344080043932504 1641 5379071
SGTC_1464 k208-0027 110 µM 0.401319769224544 0.35863898604267 no 1187 0.34409235520056 1715 X1464
SGTC_993 3909-8757 62.7 µM 0.400182037169388 0.359051769456811 no 1188 0.344511221976789 1630 4288324 YLR208W SEC13
SGTC_1234 0326-0494 15.5 µM 0.399294244838034 0.359373985988921 no 1189 0.344838203610425 1716 1547813
SGTC_1581 himbacine 57.9 µM 0.397423812988339 0.360053170155228 no 1190 0.345527479082231 1611 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_47 0149-0135 24.25 µM 0.395797578770974 0.36064404153393 no 1191 0.346127181568935 1520 5239155
SGTC_203 k066-0004 30.888 µM 0.394292002912423 0.361191370031903 no 1192 0.346682733409995 1708 6795412
SGTC_2250 alverine citrate 130 µM 0.393182039989044 0.361595061769866 no 1193 0.347092516878166 1601 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_786 4544-0069 423 µM 0.393007687029247 0.361658487678153 no 1194 0.347156901925959 1704 748821 YLR208W SEC13
SGTC_2113 5491891 107.031 µM 0.392788204088002 0.361738336320382 no 1195 0.347237958842426 1574 789979
SGTC_809 3998-0021 90 µM 0.392396557923847 0.361880833483905 no 1196 0.347382614459419 1741 715485
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.391582879348216 0.362176944796831 no 1197 0.347683219994766 1621 5282362
SGTC_3349 9149703 23.001 µM 0.388050907559859 0.3634632429314 no 1198 0.348989180404236 1608 4910494
SGTC_2301 7769476 200 µM 0.385997088422804 0.364211926655259 no 1199 0.349749412565859 1701 977820
SGTC_2054 5233173 129 µM 0.385406041354542 0.364427478690092 no 1200 0.349968303647455 1696 6889
SGTC_831 k061-1017 217 µM 0.384029244004047 0.364929756266138 no 1201 0.350478386356777 1738 1240153
SGTC_1550 gossypolone 36.6 µM 0.384024664276868 0.364931427410866 no 1202 0.350480083527433 1655 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2812 7970281 58.44 µM 0.383596120187997 0.365087814711444 no 1203 0.350638908036418 1755 2233435
SGTC_1847 st056231 15 µM 0.382996863046507 0.365306537438663 no 1204 0.350861044999935 1607 5393180
SGTC_1828 st055811 49 µM 0.382468145611085 0.365499550281915 no 1205 0.351057076137654 1770 5877589
SGTC_1249 0481-0015 10.2 µM 0.380450687064356 0.366236353458477 no 1206 0.351805447652153 1608 4227577
SGTC_3295 9122362 53.5725 µM 0.377886991313413 0.367173361533847 no 1207 0.352757273302024 1654 4730473
SGTC_1718 roemerine 11.9335 µM 0.376866538979646 0.367546548403599 no 1208 0.35313639455803 1645 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1155 4088-0394 48.2 µM 0.375192656345433 0.368158970304072 no 1209 0.353758595672107 1615 2326248
SGTC_2539 epi(13)torulosol 80 µM 0.375110550910528 0.36818901878059 no 1210 0.353789125260254 1607 6708597
SGTC_1098 clofazimine 15.1 µM 0.37368723432204 0.368710044034293 no 1211 0.354318511968238 1727 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2393 9031399 185.94 µM 0.373173608051055 0.368898123557552 no 1212 0.354509618727201 1743 1526623 YDL150W RPC53
SGTC_1578 josamycin 24.2 µM 0.371399405352039 0.369548041906117 no 1213 0.355170034205558 1609 5282165 A P450 substrate.
SGTC_64 000l-0018 272.079 µM 0.371078356239627 0.369665687144303 no 1214 0.355289585607347 1649 6811119
SGTC_2142 5622915 118.518 µM 0.370883538325674 0.369737082170917 no 1215 0.355362138320927 1657 5322196
SGTC_3329 9141233 27.5565 µM 0.369560870990485 0.370221919414735 no 1216 0.355854855259803 1752 4909101 YNL103W MET4
SGTC_1454 4239-0054 42.6 µM 0.36937465343455 0.370290195947413 no 1217 0.355924243950616 1775 1340767
SGTC_550 4123-0385 25.7 µM 0.369106325411849 0.370388585410469 no 1218 0.356024237171454 1635 5731123
SGTC_2328 6201408 200 µM 0.369070592014182 0.370401688632011 no 1219 0.356037554073806 1651 2890418
SGTC_1471 k673-0312 37 µM 0.368069334958208 0.370768904645106 no 1220 0.356410767732525 1701 24099884
SGTC_306 1672-3436 11.6 µM 0.366495791811656 0.371346247254204 no 1221 0.356997576081265 1717 6797378
SGTC_3141 9094609 49.47 µM 0.366313840606798 0.371413024968607 no 1222 0.357065451487744 1616 25236309 YDL196W YDL196W
SGTC_323 4013-0906 34.3 µM 0.366177977248975 0.3714628905565 no 1223 0.357116137150869 1792 2910086
SGTC_2796 7949634 45.45 µM 0.364070233138096 0.372236766460826 no 1224 0.357902782108733 1642 2971588
SGTC_467 ro 31-8220 72.8 µM 0.363843749621456 0.372319952553259 no 1225 0.357987345486605 1788 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1394 3474-0001 65.7 µM 0.363337160867724 0.37250604124948 no 1226 0.358176518495204 1652 5017666 YIL048W NEO1
SGTC_2040 5100729 123 µM 0.363297967270471 0.372520439741571 no 1227 0.358191155824089 1727 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2608 thymoquinone 42.66 µM 0.362652381975535 0.37275763305058 no 1228 0.358432287534964 1669 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1203 3992-3522 103 µM 0.357551350705238 0.374633483843425 no 1229 0.3603395454716 1905 5322312
SGTC_2513 baicalein 25.65 µM 0.357347489265034 0.374708513776575 no 1230 0.360415841201319 1598 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3094 9117742 49.47 µM 0.356801931245955 0.374909326331786 no 1231 0.360620045190397 1631 17149698
SGTC_1706 st031321 9.9705 µM 0.356596948198144 0.374984786598777 no 1232 0.360696781232051 1773 6103185
SGTC_2334 9017922 200 µM 0.355007930026332 0.375569912897315 no 1233 0.361291825194654 1821 3163164
SGTC_1442 4112-3290 3 µM 0.354309149020497 0.375827316689223 no 1234 0.361553605992977 1692 704353
SGTC_2569 tetrandrine 100 µM 0.353272439783729 0.376209301911767 no 1235 0.361942102525543 1623 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2801 7907800 81.82 µM 0.352190939669675 0.376607920021768 no 1236 0.362347535655573 1679 6620925
SGTC_2050 5263056 171 µM 0.351265470473913 0.376949132944567 no 1237 0.362694598516161 1830 763468 YGL055W OLE1
SGTC_181 1447-1644 8.07 µM 0.350751990665754 0.377138490229005 no 1238 0.362887208743481 1817 534600
SGTC_2420 aureobasidin a 50 nM 0.350478375324999 0.377239404140678 no 1239 0.362989858134923 1832 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2259 7964009 200 µM 0.350455339617647 0.37724790047736 no 1240 0.362998500648496 1754 313134
SGTC_2908 7930301 100 µM 0.348028367011779 0.37814338104275 no 1241 0.363909439919993 1630 2223178
SGTC_1190 1486-1332 13 µM 0.347839642889306 0.378213042128673 no 1242 0.363980307899945 1648 4150046
SGTC_1779 st039427 55 µM 0.347279795312527 0.378419714089567 no 1243 0.364190564173824 1896 1124498
SGTC_3151 9099821 49.47 µM 0.346976790455896 0.378531585132254 no 1244 0.364304377688348 1665 17174189
SGTC_3197 9113331 49.47 µM 0.346962752217928 0.37853676837297 no 1245 0.364309650967217 1816 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1623 st003709 20.3 µM 0.346848556068623 0.378578933032682 no 1246 0.364352548198186 1657 16192618
SGTC_1884 5633444 25 µM 0.346287460706506 0.378786127340575 no 1247 0.364563345631373 1747 5724239
SGTC_2703 st077852 53.4 µM 0.346220360352122 0.378810907657408 no 1248 0.364588557249038 1724 6281836
SGTC_1185 1319-0113 81.3 µM 0.341226072517175 0.380656701708762 no 1249 0.366466698425671 1769 4672763
SGTC_1332 1480-0653 17.5 µM 0.340910397189768 0.380773461149757 no 1250 0.366585518685919 1833 5749438
SGTC_1850 st056238 17 µM 0.340752380471722 0.380831911176404 no 1251 0.366645001015459 1685 5393177
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.338698085447571 0.381592037316517 no 1252 0.367418591549971 1945 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_736 0958-0254 92.6 µM 0.33761285759975 0.38199377577596 no 1253 0.367827475797984 1764 6812352
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.337165133021001 0.382159555157546 no 1254 0.367996209890055 1688 688803
SGTC_833 3852-0053 558 µM 0.334473856424893 0.383156510831629 no 1255 0.369011007795371 1782 3123681
SGTC_566 0958-0068 16.5 µM 0.334207426819374 0.383255249165018 no 1256 0.369111520053969 1774 6815365
SGTC_3243 9134147 49.47 µM 0.334052217600269 0.383312772919349 no 1257 0.369170077842471 1783 24282180
SGTC_1060 3448-7350 82 µM 0.333651198753264 0.383461410725543 no 1258 0.369321389460448 1833 570178
SGTC_2143 5623677 140.463 µM 0.333252022312958 0.3836093826786 no 1259 0.369472026012894 1782 5375313
SGTC_1030 k029-0042 36.7 µM 0.331999693176979 0.384073722531222 no 1260 0.369944745344607 1741 6080581
SGTC_1127 asiatic acid 681.4 nM 0.331963131815549 0.38408728129336 no 1261 0.369958549195752 1670 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1408 3909-7976 48.8 µM 0.330673528069791 0.384565620818766 no 1262 0.370445549994669 1760 24152374
SGTC_1418 3966-3099 2.4 µM 0.330620555849303 0.384585273026544 no 1263 0.370465558658432 1802 740335
SGTC_1470 k295-0292 231 µM 0.330057486176683 0.384794185031669 no 1264 0.370678262948918 1818 5045612
SGTC_2074 5212007 75.395 µM 0.329792703255157 0.384892437250894 no 1265 0.370778300588038 1875 758611
SGTC_1516 st013856 110 µM 0.328906484744564 0.385221337484708 no 1266 0.371113186330455 1738 5281404 A mutagen and neurotoxin.
SGTC_1500 4488-1866 171 µM 0.328826933006828 0.385250865380449 no 1267 0.371143252253617 1829 2900003
SGTC_2211 7117706 200 µM 0.328383023842229 0.385415647133654 no 1268 0.371311038495719 1815 822771
SGTC_2448 5185112 27.17 µM 0.327264582582008 0.385830910920931 no 1269 0.371733888899142 1721 5718189
SGTC_2485 5633444 17.78 µM 0.326429779959986 0.386140948417687 no 1270 0.372049604628162 1675 5724239
SGTC_2957 9076800 11.52 µM 0.326315656656747 0.386183338346763 no 1271 0.372092771846047 1677 16459615
SGTC_1810 st050138 53 µM 0.325879986430309 0.38634517606836 no 1272 0.372257579186967 1843 3444541
SGTC_1481 3346-2004 36 µM 0.32507685447647 0.386643566016072 no 1273 0.372561452951889 1752 2770522
SGTC_2790 5423970 71.43 µM 0.317883181243255 0.38931922178437 no 1274 0.375286775410655 1856 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1853 st056710 91.2 µM 0.317252701187758 0.389553978474816 no 1275 0.375525931940783 1898 269167
SGTC_1625 st003711 30.1 µM 0.316807984583872 0.389719591145599 no 1276 0.375694652622101 1832 24207034 YER133W GLC7
SGTC_1694 st024011 44.9 µM 0.313249455380869 0.391045507930615 no 1277 0.377045573860578 1771 2787533
SGTC_2377 9073351 62.6 µM 0.313143631083442 0.39108495780723 no 1278 0.377085770989628 1712 7337946 YHR072W ERG7
SGTC_2391 6285546 200 µM 0.313070869585019 0.391112082966677 no 1279 0.377113410059284 1712 846083
SGTC_1760 st045453 10.4495 µM 0.309606443786165 0.39240421608117 no 1280 0.378430127747313 1884 3323419 YIL048W NEO1
SGTC_789 1309-1135 70.6 µM 0.309541279346519 0.392428531997782 no 1281 0.378454908255767 1686 3092424
SGTC_1717 st033143 58.0435 µM 0.309268515488817 0.392530317576056 no 1282 0.378558639379173 1876 674616
SGTC_228 caffeine 993.056 µM 0.308957126299939 0.392646525713368 no 1283 0.378677070275382 1855 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3310 9130229 44.1445 µM 0.308471136161247 0.39282791275325 no 1284 0.378861930053843 1857 7761258
SGTC_1287 0971-0001 34.6 µM 0.30643460393629 0.393588264322344 no 1285 0.379636882313744 1805 4665869
SGTC_373 0844-0104 25.9 µM 0.30502742014551 0.394113882207469 no 1286 0.380172634299434 1886 5375804
SGTC_2702 st077768 96.8 µM 0.304281381112481 0.394392624515002 no 1287 0.380456764394865 1723 6484119
SGTC_3184 9108758 49.47 µM 0.304180736161591 0.394430232597148 no 1288 0.380495100118126 1779 902885
SGTC_1284 0929-0043 16 µM 0.303959868634164 0.394512767797991 no 1289 0.380579232807584 1772 1239883
SGTC_2399 5884133 200 µM 0.303864210419878 0.394548515445789 no 1290 0.380615672614487 1718 722445
SGTC_3108 9121785 49.47 µM 0.303716583925704 0.394603685476473 no 1291 0.380671911169792 1891 17140271
SGTC_3200 9114385 49.47 µM 0.303183645480256 0.394802869412193 no 1292 0.380874955920285 1714 17018030 YLR208W SEC13
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.302454448591906 0.395075448821316 no 1293 0.381152826519433 1651 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1642 st009582 77.7 µM 0.302383886010344 0.395101828384744 no 1294 0.381179718625479 1906 6739311
SGTC_2792 7535235 81.82 µM 0.300900612426079 0.395656455897193 no 1295 0.381745141649239 1698 1281891
SGTC_3066 9117245 49.47 µM 0.300358946958233 0.395859048872888 no 1296 0.381951687188323 1866 17176980
SGTC_2071 5230951 39.92 µM 0.297993790595086 0.39674399038632 no 1297 0.382853951421855 1870 1799272
SGTC_1088 bifonazole 369 nM 0.29615550878354 0.397432165453774 no 1298 0.383555662171059 1794 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1166 k206-0078 225 µM 0.293757959786122 0.398330186168626 no 1299 0.384471430808905 1754 5404595
SGTC_2976 9009005 19.48 µM 0.293736989092326 0.398338043289372 no 1300 0.3844794436357 1939 2993148
SGTC_2306 7482397 179.52 µM 0.291990001620616 0.398992734101305 no 1301 0.385147134291309 1897 891448
SGTC_986 1493-0483 84 µM 0.291984016243664 0.398994977635836 no 1302 0.385149422461786 1904 40079
SGTC_1693 xanthone 101.9 µM 0.291048250776234 0.399345777182165 no 1303 0.385507208618909 1856 7020 An insecticide.
SGTC_561 1550-0330 72.9 µM 0.29066479693814 0.39948954976605 no 1304 0.385653848815767 1760 6812934
SGTC_222 nsc-310342 10.666 µM 0.289463551138732 0.399940034278936 no 1305 0.386113334259419 1902 432556
SGTC_2164 5685496 200 µM 0.288816106519148 0.400182890637016 no 1306 0.386361052950155 1884 759046
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.288337169845794 0.400362564541745 no 1307 0.386544328654959 1789 5106787 A p450 inhibitor.
SGTC_2782 7736369 71.43 µM 0.28757285254286 0.400649343139835 no 1308 0.386836863977779 1754 2950836 YOL077C BRX1
SGTC_2873 9040596 71.43 µM 0.287007199731895 0.400861615562544 no 1309 0.387053403732856 1750 6463863
SGTC_244 nsc-207895 1.295 µM 0.286567291620787 0.401026720035822 no 1310 0.387221830975807 1769 42640
SGTC_2123 5259487 200 µM 0.285128364790074 0.40156689537378 no 1311 0.387772899825494 1898 2173474
SGTC_2270 7924575 90.91 µM 0.284365175382952 0.401853474272736 no 1312 0.388065271930567 1949 1262135
SGTC_867 0518-0118 155 µM 0.2836167849929 0.402134547374302 no 1313 0.388352036269738 1957 6848158
SGTC_898 1000-0849 28.3 µM 0.283505729570531 0.402176260793696 no 1314 0.388394595099579 1921 6751807
SGTC_308 4092-1169 104 µM 0.282611333102397 0.402512244761801 no 1315 0.388737395900655 1831 2268590 YDL196W YDL196W
SGTC_2446 5162541 200 µM 0.282541255138673 0.40253857290302 no 1316 0.388764258774406 1768 1549321
SGTC_1761 st044296 37 µM 0.281960971059663 0.402756601366287 no 1317 0.388986718568258 1766 1826700
SGTC_1463 k081-0032 34.1 µM 0.28188278399943 0.402785980678523 no 1318 0.389016695425471 1757 977755
SGTC_1720 st037298 9.481 µM 0.280883532778873 0.403161504309307 no 1319 0.389399865675185 1782 597396
SGTC_387 norethindrone acetate 66.7 µM 0.280238293165768 0.403404036083714 no 1320 0.389647344736793 1775 541197
SGTC_2274 7947094 46.08 µM 0.279836591889195 0.403555045777247 no 1321 0.389801438257478 1793 2971028
SGTC_1757 st041620 31.8375 µM 0.27815626625657 0.404186878414614 no 1322 0.390446202501702 1781 5289815
SGTC_1591 genipin 88.4 µM 0.276467737000003 0.404822047624426 no 1323 0.391094418227183 1891 442424 A DNA cross-linking agent.
SGTC_1432 4049-0298 68.4 µM 0.276389519045249 0.404851476740353 no 1324 0.391124452954667 1944 741646
SGTC_1620 st003704 16.5 µM 0.274405502043151 0.405598132774731 no 1325 0.391886507609204 1943 2834414
SGTC_2355 9061122 103.12 µM 0.274092414124633 0.405715990333822 no 1326 0.392006801670797 1920 5302957
SGTC_3324 9138759 60.749 µM 0.273606465214537 0.405898935915549 no 1327 0.392193532505813 1845 45595710
SGTC_1308 1187-1617 41.4 µM 0.273471774924379 0.405949646518088 no 1328 0.392245293022726 1804 2882570
SGTC_408 cantharidin 100 µM 0.273178335082609 0.406060131446065 no 1329 0.392358066459357 1853 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2646 retinol 96.75 µM 0.272215201968459 0.406422819442506 no 1330 0.392728276787323 1846 445354 A vitamin A analog and teratogen.
SGTC_261 5-fluorouridine 15.376 µM 0.271157760881666 0.4068211135564 no 1331 0.393134849119067 1913 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2005 4024620 188 µM 0.270107843482201 0.407216669186049 no 1332 0.393538644045119 1821 236743
SGTC_1130 3454-2858 15.9 µM 0.269535075117312 0.407432499183262 no 1333 0.393758977263485 1743 715628 YIL048W NEO1
SGTC_210 3551-0445 56.827 µM 0.26946304061036 0.40745964514434 no 1334 0.393786689993167 1881 2865180 YOR207C RET1
SGTC_2374 9071832 200 µM 0.267155348860316 0.408329525477579 no 1335 0.39467477672608 1910 17381698
SGTC_67 0335-0847 266 µM 0.266317198900116 0.408645576729409 no 1336 0.394997464223388 2008 4552207 YOR254C SEC63
SGTC_2617 dihydrotanshinone i 20.83 µM 0.266009900421771 0.408761468347545 no 1337 0.395115792109038 1798 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_21 0849-0113 22.993 µM 0.265693529625534 0.408880789747791 no 1338 0.395237623473159 1804 1560156
SGTC_1122 capsaicin 818.572 nM 0.264955201713554 0.409159287981998 no 1339 0.395521986301475 1900 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_972 1319-0219 195 µM 0.264315888508851 0.409400474794431 no 1340 0.395768259121914 1802 23903702
SGTC_2239 6685329 187.64 µM 0.26357677253632 0.409679355863334 no 1341 0.396053029297432 1799 805680
SGTC_2357 9067248 200 µM 0.263257707463691 0.409799758691464 no 1342 0.396175977384891 1857 9150235
SGTC_2726 cimetidine 79.27 µM 0.262764145837645 0.409986026527921 no 1343 0.396366186069624 1924 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1742 st038235 28.8875 µM 0.261854752014731 0.410329280645962 no 1344 0.396716712657326 1837 564103 YBR002C RER2
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.26053811115306 0.410826373376369 no 1345 0.397224360803449 1800 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2174 5790901 200 µM 0.260048727976225 0.411011174686925 no 1346 0.397413093347253 1833 786020
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.259999412730798 0.411029798249919 no 1347 0.397432113298221 1939 94937 An inhibitor of serotonin biosynthesis.
SGTC_1266 0828-0227 32.9 µM 0.258924663235549 0.411435719736657 no 1348 0.397846684208028 1894 3913820
SGTC_975 1335-0046 28.5 µM 0.258709383916101 0.411517039865334 no 1349 0.397929739344685 1758 16486740
SGTC_493 zm226600 134 µM 0.257483086044946 0.411980336973961 no 1350 0.398402935318587 1889 5240098 A potassium channel opener. YCR052W RSC6
SGTC_197 4544-0043 41.561 µM 0.256299895922573 0.412427464243075 no 1351 0.398859638806046 1857 896523
SGTC_538 2922-0838 53.3 µM 0.255628904949495 0.412681082124871 no 1352 0.399118698430658 1979 777039
SGTC_2233 sulbentine 40.3845 µM 0.254774627376204 0.413004030521362 no 1353 0.399448586573492 1921 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2777 climbazole 1.536 µM 0.252505983837461 0.413861946622137 no 1354 0.400324994748544 1906 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2111 5486399 200 µM 0.250892720720114 0.414472272845129 no 1355 0.400948526239783 1836 689674
SGTC_676 falcarinol 140 µM 0.246425212261192 0.41616348468091 no 1356 0.402676545657256 1987 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1989 st071868 50.2 µM 0.24580569597503 0.416398130991408 no 1357 0.402916323786271 1992 16414057
SGTC_2467 5474540 200 µM 0.245445364875158 0.416534622733589 no 1358 0.4030558034543 1845 5413519
SGTC_278 4092-0821 23.9 µM 0.245313786394202 0.416584466558648 no 1359 0.403106738916535 1934 877900
SGTC_1280 0880-0253 10.1 µM 0.244599524432773 0.416855062665964 no 1360 0.403383266162015 1875 6836607
SGTC_3199 9111318 49.47 µM 0.244564199343879 0.416868446498615 no 1361 0.403396943561092 1937 8548020
SGTC_1265 0819-1001 68.8 µM 0.244147772414165 0.417026227977042 no 1362 0.403558187367238 1899 3106768
SGTC_924 2046-0044 21.3 µM 0.243465947366405 0.41728459593571 no 1363 0.40382223081193 1831 3623589
SGTC_122 0236-0016 402.397 µM 0.242718136655692 0.417568009297791 no 1364 0.404111878252098 1879 6808838
SGTC_2751 anetholtrithion 17.25 µM 0.242458030353768 0.417666597233127 no 1365 0.404212636833865 1974 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3006 9075424 71.4286 µM 0.242032616498897 0.417827852742106 no 1366 0.404377445060085 1828 7465181
SGTC_392 N-ethylmaleimide 8.33 µM 0.241832210105392 0.417903822699527 no 1367 0.404455089744483 1839 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_570 0987-0065 62.6 µM 0.239279515176122 0.418871764139961 no 1368 0.405444424313451 2004 3104428
SGTC_333 3486-0131 40.1 µM 0.238911486870207 0.419011355299274 no 1369 0.405587109111166 1995 6744690
SGTC_1881 5652484 16 µM 0.23847352837554 0.419177483888597 no 1370 0.405756922232736 1996 2255129
SGTC_2508 celastrol 40.54 µM 0.238293674852064 0.419245710995241 no 1371 0.4058266634054 1985 122724 Celastrol is a natural product and antioxidant.
SGTC_167 3672-0051 66.205 µM 0.237773458982568 0.419443067600485 no 1372 0.406028402514946 1858 3237971
SGTC_2378 9074213 121.43 µM 0.237726397508971 0.419460922521161 no 1373 0.406046654131392 1878 657714
SGTC_2730 imipramine 71.33 µM 0.237674511962329 0.4194806078666 no 1374 0.406066776880676 1992 3696 A tricyclic antidepressant.
SGTC_2855 9016525 58.44 µM 0.237369797969737 0.419596220238979 no 1375 0.406184958984019 1902 43811474
SGTC_1575 cyproterone acetate 48 µM 0.236586507544599 0.419893442438572 no 1376 0.406488794248318 1826 9880 An androgen receptor antagonist and liver toxin.
SGTC_2737 bleomycin 30.5 nM 0.235853398034599 0.420171664724355 no 1377 0.406773215552135 1921 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1960 st011366 51.8 µM 0.235389986306997 0.420347554631673 no 1378 0.406953028761592 1914 3972846
SGTC_3317 9138495 8.753 µM 0.235233536182999 0.420406939540132 no 1379 0.407013739033991 1913 17020139
SGTC_128 0906-2981 13.371 µM 0.234834605734138 0.420558372661102 no 1380 0.407168553598289 1999 6740226
SGTC_1724 st037281 8.293 µM 0.234447532462354 0.420705316062849 no 1381 0.407318780563681 1831 574124 YDL195W SEC31
SGTC_708 3448-5400 146 µM 0.233691129445127 0.420992498822957 no 1382 0.407612387389192 1992 3462195
SGTC_2075 5212009 200 µM 0.232902044287022 0.421292134786373 no 1383 0.40791873549016 1969 780898
SGTC_2612 dictamnine 15.46 µM 0.232737389699307 0.421354664129832 no 1384 0.407982666774687 1891 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1628 st004252 77.7 µM 0.231053472800208 0.42199426320837 no 1385 0.408636630219909 1984 692968
SGTC_3352 9151559 45.5865 µM 0.229455117464052 0.422601554010596 no 1386 0.409257600554517 1890 17159339
SGTC_2775 cyproheptadine 69.59 µM 0.228234684643633 0.423065378144835 no 1387 0.409731899238991 2029 2913 A selective serotonin reuptake inhibitor.
SGTC_246 cycloheximide 667 µM 0.227858966922766 0.423208190747826 no 1388 0.409877941626198 1895 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1381 2324-0066 62.1 µM 0.22506732986598 0.424269623855323 no 1389 0.410963447978634 1918 10885928
SGTC_352 k048-0007 5.11 µM 0.224264713481607 0.424574895800783 no 1390 0.411275665741548 1995 6811911
SGTC_1990 st072050 59.8 µM 0.222740150607406 0.425154881674796 no 1391 0.411868875294543 1850 17233948
SGTC_2068 5226020 147 µM 0.221579378771646 0.425596580093831 no 1392 0.412320668412489 1870 1810509
SGTC_2185 6113692 200 µM 0.221266665463432 0.42571559016257 no 1393 0.412442401909932 1916 874150
SGTC_2414 st077232 92.9 µM 0.221014884885265 0.425811415831556 no 1394 0.412540421546301 1774 729801
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.220386512097833 0.426050588576283 no 1395 0.412785074490722 1957 5393153
SGTC_469 w7 172 µM 0.220165735849748 0.426134627419563 no 1396 0.412871040365793 1969 45115570 A P450 inhibitor.
SGTC_1317 1273-0028 910 nM 0.218573707484477 0.426740734728 no 1397 0.413491067977777 1914 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1105 epirubicin 18.1 µM 0.218202508929019 0.426882080100558 no 1398 0.413635665169391 1871 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2943 9068529 45.32 µM 0.217419238053178 0.427180365587963 no 1399 0.413940819983925 2000 3270634
SGTC_59 0330-0160 1.33 µM 0.217204472384946 0.427262160005275 no 1400 0.414024499712967 1966 4293482
SGTC_3091 9116372 49.47 µM 0.2165520526009 0.427510656016273 no 1401 0.414278727726354 1949 17169793
SGTC_250 brefeldin a 552.239 µM 0.214975771864711 0.428111154033446 no 1402 0.414893104096983 1935 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2931 9014674 55.67 µM 0.214768845052244 0.428189997018131 no 1403 0.414973772065694 1892 2996810
SGTC_2272 7805186 180 µM 0.214598481346757 0.428254910927198 no 1404 0.415040189030888 2066 2956062 YPR165W RHO1
SGTC_810 3825-7150 143 µM 0.213829502831443 0.428547939966415 no 1405 0.415340008539826 2079 22330411 YGL099W LSG1
SGTC_3101 9120531 49.47 µM 0.211363114937049 0.429488053461471 no 1406 0.416301968278275 2034 24824904
SGTC_902 1120-0002 2.07 µM 0.210671190681276 0.429751866432728 no 1407 0.416571928283977 1898 3280475
SGTC_354 2783-3500 4.88 µM 0.210292169846049 0.429896390661573 no 1408 0.416719823107609 1854 6740761
SGTC_790 1575-0012 79.1 µM 0.20980665709838 0.430081534985261 no 1409 0.416909288545772 2053 378741 YLR208W SEC13
SGTC_769 0302-0231 76 µM 0.209362005668128 0.430251110836663 no 1410 0.417082825285853 1983 571869 YER009W NTF2
SGTC_16 erodoxin 22.806 µM 0.209077903242796 0.43035946516414 no 1411 0.417193712078479 1992 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3057 9095946 49.47 µM 0.207568255280736 0.430935320250483 no 1412 0.41778304655139 1992 24540043
SGTC_514 4466-0038 2.65 nM 0.205509938735796 0.431720701325083 no 1413 0.418586866914295 1951 5722064
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.205117729515953 0.431870385262216 no 1414 0.4187400723897 2019 5282309
SGTC_2405 ticlatone 3.52 µM 0.204144482012094 0.432241860650948 no 1415 0.419120297284469 1794 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3087 9117406 49.47 µM 0.204077353860926 0.432267484769233 no 1416 0.419146525462487 1932 42546093
SGTC_761 k216-0224 480 µM 0.204062247263674 0.432273251289906 no 1417 0.419152427931721 2089 1340404
SGTC_2112 5488546 200 µM 0.203446173892653 0.432508432333718 no 1418 0.419393156404105 1954 600757
SGTC_2734 clemastine 41.6 µM 0.20335323927676 0.432543911452034 no 1419 0.419429472895158 2044 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2673 kobusone 100 µM 0.202996816553841 0.432679985962759 no 1420 0.419568760217388 1994 6710676 An epoxy ketone and protein crosslinker.
SGTC_1962 st076595 64.5 µM 0.201795284808284 0.433138763608293 no 1421 0.420038383949861 1934 279619
SGTC_1911 st060208 74.3 µM 0.199833909704046 0.433887863572353 no 1422 0.420805240036113 2015 688783
SGTC_2360 9040895 200 µM 0.19917653163438 0.434138986562776 no 1423 0.421062328330662 1920 4914414
SGTC_2875 9039966 71.43 µM 0.198754987294411 0.434300033424163 no 1424 0.421227204176389 2037 6463691
SGTC_3009 9080819 71.4286 µM 0.196086097548551 0.435319908436819 no 1425 0.422271388789908 1926 17027216
SGTC_2326 6164455 177.58 µM 0.194369886527829 0.435975959786606 no 1426 0.422943133658934 1932 2888790
SGTC_1354 1498-1681 81 µM 0.194340703334398 0.435987117095797 no 1427 0.422954558242109 1961 5754243
SGTC_1419 3993-2473 62.6 µM 0.194061196541763 0.436093980622709 no 1428 0.423063982330736 1986 704026
SGTC_88 0180-0332 8.668 µM 0.193904289611839 0.436153972723071 no 1429 0.423125412412123 1985 3101745
SGTC_2484 5809818 12.04 µM 0.193434235291861 0.436333702990907 no 1430 0.423309452909673 1942 2870548
SGTC_187 1488-2104 32.728 µM 0.19336060082427 0.436361859104529 no 1431 0.423338284550148 2051 2852859
SGTC_537 1334-0398 209 µM 0.192242049189037 0.436789606894825 no 1432 0.423776304819216 2084 5846986
SGTC_3044 9093193 49.47 µM 0.191904794022421 0.436918591910391 no 1433 0.423908391077022 1900 25236277
SGTC_998 3996-0085 177 µM 0.191278319045906 0.437158208354825 no 1434 0.424153773185149 2046 715391
SGTC_543 3844-1095 191 µM 0.189944688816964 0.437668376798297 no 1435 0.424676236630853 2027 4230703
SGTC_1337 1486-1011 40.3 µM 0.188700672007869 0.438144357865508 no 1436 0.425163712432378 2090 X1337
SGTC_2825 7998094 58.44 µM 0.186920784225484 0.438825527351567 no 1437 0.425861371472592 1977 2987815
SGTC_1372 2752-0194 270 µM 0.186470611788255 0.43899783876383 no 1438 0.426037861525977 2008 823334
SGTC_169 k015-0017 16.025 µM 0.185596394982272 0.43933249360762 no 1439 0.426380640418305 2064 1840002
SGTC_147 4466-0538 29.23 µM 0.184779233050174 0.439645346758207 no 1440 0.426701098492871 1986 6742687 YHR072W ERG7
SGTC_3355 9151058 44.0485 µM 0.184530949458063 0.439740410428892 no 1441 0.426798474935802 2094 17015728
SGTC_472 calcifediol 10 µM 0.183857079438611 0.439998441583425 no 1442 0.427062788191378 1991 5283731 A vitamin D metabolite.
SGTC_2644 guaiazulene 100 µM 0.183851267010277 0.440000667327806 no 1443 0.427065068153272 2074 3515 A coloring agent.
SGTC_1504 k297-0033 30 µM 0.182729431565149 0.440430285493311 no 1444 0.427505160750615 1901 4388117
SGTC_943 3253-1379 105 µM 0.182077888563586 0.440679832665795 no 1445 0.427760800519422 2022 668464
SGTC_556 4058-0063 51.5 µM 0.182021941829323 0.440701261897418 no 1446 0.427782753226146 1969 6615692
SGTC_2021 4019055 173 µM 0.181895823569681 0.440749569507569 no 1447 0.427832241066205 2027 44827708 YER133W GLC7
SGTC_2903 5923464 63.88 µM 0.181759861967894 0.44080164844231 no 1448 0.427885592630032 2111 2876576
SGTC_1050 3232-1156 69.3 µM 0.180123294304506 0.441428601840349 no 1449 0.428527887740045 1936 700529
SGTC_2583 asiatic acid 100 µM 0.178492301885609 0.442053565466572 no 1450 0.429168183164635 2024 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1906 st060206 94.7 µM 0.177846544751813 0.442301046618392 no 1451 0.429421746277374 2081 5133468
SGTC_1180 1193-0155 285 µM 0.177302966063431 0.442509386175619 no 1452 0.42963521056229 1987 2921347
SGTC_1573 oleylamine 1.06 µM 0.177038906854624 0.44261059893625 no 1453 0.42973891449593 1959 5356789 An amine of the fatty acid oleic acid.
SGTC_1534 6-azauridine 81.6 µM 0.176444285882838 0.442838528305086 no 1454 0.429972457641335 2022 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1485 3909-9022 254 µM 0.175488492220251 0.443204941553923 no 1455 0.430347906174817 2085 714516
SGTC_691 1548-0686 185 µM 0.174944312122557 0.443413580264608 no 1456 0.430561695552739 1953 46495133
SGTC_1966 st070145 16.1 µM 0.174867539348094 0.44344301621907 no 1457 0.430591858537524 2022 3748532
SGTC_814 3342-0569 96 µM 0.174036358819273 0.443761724559561 no 1458 0.430918444014339 2061 4346283
SGTC_3049 9092223 49.47 µM 0.17364322309684 0.443912481432002 no 1459 0.431072930438974 2005 8623917
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.172765471504273 0.444249104588924 no 1460 0.43141788930883 1958 688664
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.172198676990049 0.444466495172795 no 1461 0.431640668977487 1994 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_783 0848-0141 92.7 µM 0.171822274081683 0.444610871451244 no 1462 0.431788626880426 2047 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_322 k048-0136 19.3 µM 0.171456115056721 0.444751325551228 no 1463 0.431932567260745 2031 6823282
SGTC_310 1273-0058 1.06 µM 0.17055009053951 0.44509889519893 no 1464 0.432288772389624 2071 2734232
SGTC_119 0121-0043 24.815 µM 0.17036526264695 0.445169804173912 no 1465 0.43236144456922 2125 1092378
SGTC_668 1682-0499 62.6 µM 0.169874273132521 0.44535818016186 no 1466 0.432554507048113 1984 682214
SGTC_44 0929-0055 61.211 µM 0.169331273514257 0.44556652502488 no 1467 0.432768039222586 1997 1379590
SGTC_894 0960-0238 55.9 µM 0.167979395374827 0.446085295666733 no 1468 0.433299744422833 2101 6741907 YDL195W SEC31
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.167971916450224 0.446088165891929 no 1469 0.433302686284404 2018 1377
SGTC_995 3931-2021 34.6 µM 0.167711409254748 0.446188143834348 no 1470 0.433405160020727 2005 730143
SGTC_149 3970-0822 46.1 µM 0.166756609854697 0.446554607748577 no 1471 0.433780780432015 2027 3114250 YBL034C STU1
SGTC_1300 1094-0077 113 µM 0.166690384426549 0.446580027590092 no 1472 0.433806835898826 1996 5532636
SGTC_2586 curcumin 80 µM 0.16580445782304 0.446920101029567 no 1473 0.434155418924611 2075 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1342 1486-1464 234 µM 0.164158900629713 0.447551871088595 no 1474 0.434803027332579 1989 3253938
SGTC_2805 7950783 58.44 µM 0.162373060591796 0.448237649740727 no 1475 0.435506041918869 2038 1178958 YDL195W SEC31
SGTC_1754 st042065 16.137 µM 0.162221243445242 0.448295956056098 no 1476 0.435565815758242 2036 1126236 YIL048W NEO1
SGTC_2645 abamectin 100 µM 0.162080606716632 0.448349969459334 no 1477 0.43562118892809 2092 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1583 clindamycin 39.6 µM 0.161357721375673 0.448627618262359 no 1478 0.435905831859716 1937 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1909 st060837 51.5 µM 0.161348708092214 0.4486310802808 no 1479 0.435909381135101 1992 678937
SGTC_2268 7933382 153.85 µM 0.161126635092774 0.448716380155467 no 1480 0.435996831277128 2144 935025 YOR257W CDC31
SGTC_2354 9060492 162 µM 0.160847337264178 0.448823663873753 no 1481 0.436106820430722 2098 6471895
SGTC_332 4112-0506 40.9 µM 0.159723385724534 0.449255433231795 no 1482 0.436549489129639 2017 2790355
SGTC_2313 7726885 200 µM 0.158049158967509 0.449898703744575 no 1483 0.437209031112831 2018 726423
SGTC_350 k064-0020 19.8 µM 0.157247760823122 0.450206663213807 no 1484 0.437524794388425 2131 2790705
SGTC_405 ebelactone b 50 µM 0.156384908420135 0.450538271704438 no 1485 0.43786481607641 1997 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1334 1486-0610 236 µM 0.155140155225497 0.451016711784112 no 1486 0.438355413054729 2079 3742339
SGTC_3056 9094900 49.47 µM 0.153821685324921 0.451523563624878 no 1487 0.438875167456503 1995 25236784
SGTC_2596 sinensetin 100 µM 0.152004677058965 0.45222219506492 no 1488 0.439591623380433 2019 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3266 9136860 49.47 µM 0.150033654356349 0.452980211601196 no 1489 0.440369031715295 2098 4871271 YPR165W RHO1
SGTC_415 dibenzyl ketone 100 µM 0.149122152728111 0.453330815305052 no 1490 0.440728622990133 2120 7593
SGTC_2623 humulene 100 µM 0.148619882584703 0.453524026105589 no 1491 0.440926791608421 2028 6187145 An anti-inflammatory.
SGTC_1223 0764-0573 147 µM 0.147247435879714 0.454052028099624 no 1492 0.441468360102669 2096 1609797
SGTC_1310 1188-0297 994 nM 0.146385989746795 0.454383481622211 no 1493 0.441808343365657 2078 1588352
SGTC_875 0709-0210 25.7 µM 0.145230345448721 0.454828181882703 no 1494 0.442264503857194 2193 6251364
SGTC_423 5-fluorouracil 457 µM 0.144298995622571 0.455186613240989 no 1495 0.442632185692528 1899 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_198 3454-2873 16.191 µM 0.143985539497088 0.45530725551501 no 1496 0.442755944227161 2047 710957
SGTC_347 4534-1311 26.2 µM 0.143646053666337 0.455437920691242 no 1497 0.442889986092748 2132 2862016
SGTC_195 4234-0266 16.654 µM 0.143645503296508 0.455438132527773 no 1498 0.442890203404916 2036 2303354
SGTC_955 1216-0110 33 µM 0.14328866108105 0.4555754832318 no 1499 0.443031105286145 2076 3619719
SGTC_2832 7992762 51.95 µM 0.143178181434004 0.455618008586272 no 1500 0.443074730482181 1858 2985177
SGTC_2353 9059630 146.67 µM 0.142043565175462 0.456054769576972 no 1501 0.443522797250708 2121 4779114
SGTC_2256 7954252 200 µM 0.14128128815717 0.456348231564753 no 1502 0.44382386561179 2028 2972920
SGTC_2455 5377712 9.75 µM 0.140906050889283 0.456492699450114 no 1503 0.443972080962645 1972 2243908
SGTC_516 3992-2719 87.3 µM 0.14057956742409 0.456618401601259 no 1504 0.444101045375649 2077 5350887 YDR037W KRS1
SGTC_1709 st033179 39.1045 µM 0.140273487042648 0.456736252132215 no 1505 0.444221955731477 2158 573381
SGTC_433 pimozide 108 µM 0.140194930077797 0.456766499637567 no 1506 0.444252988778772 1940 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2739 tacrine 100.86 µM 0.139413826247631 0.45706726877609 no 1507 0.444561573644172 2080 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1174 0739-0097 51.1 µM 0.139028602423626 0.457215610795371 no 1508 0.444713773532831 2056 728447
SGTC_1136 pergolide 1.05886 µM 0.138745748821918 0.457324535878508 no 1509 0.444825532681239 2009 47811 A dopamine receptor agonist.
SGTC_2736 butenafine 14.65 µM 0.137397974299573 0.457843598977192 no 1510 0.44535811606911 2136 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2400 5203494 178.7 µM 0.136421099754189 0.458219863826534 no 1511 0.445744197208447 2158 6777674
SGTC_289 k017-0060 526 µM 0.133802093072223 0.459228816040023 no 1512 0.446779536024172 2114 5512909
SGTC_2822 7994718 71.43 µM 0.133552102660895 0.459325136761343 no 1513 0.446878380656151 2170 1018011
SGTC_1198 1612-1005 86.7 µM 0.133258044565631 0.459438439714002 no 1514 0.446994653596017 2151 6998509
SGTC_454 lyso-paf C-16 6.67 µM 0.132628967461051 0.459680839240586 no 1515 0.447243411038392 2023 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2481 5478948 45.16 µM 0.132411115824201 0.459764786556562 no 1516 0.447329561468054 2053 77792
SGTC_2292 7671323 168.05 µM 0.131566810545629 0.460090149485598 no 1517 0.447663469308494 2049 937504
SGTC_1004 4084-0029 199 µM 0.131330719703694 0.460181134647916 no 1518 0.447756845717211 2178 716894 YLR208W SEC13
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.131093825320218 0.460272431576372 no 1519 0.447850542845114 2010 803109
SGTC_1674 st016616 23.6 µM 0.130752100139638 0.460404133023692 no 1520 0.447985708067468 2074 625830
SGTC_2031 5180455 200 µM 0.13059320233121 0.460465373981146 no 1521 0.448048560213275 2169 29949
SGTC_649 1123-0311 367 µM 0.12993834996552 0.460717771142765 no 1522 0.448307601297987 2169 693629 YIL048W NEO1
SGTC_2755 lomerizine 42.69 µM 0.129923547119533 0.460723476728547 no 1523 0.448313457140597 2073 3949 A calcium channel blocker.
SGTC_2166 5933061 31.504 µM 0.129682794981292 0.460816272990146 no 1524 0.44840869761141 2127 2877375
SGTC_2878 9043973 25.97 µM 0.128087393072165 0.461431263405476 no 1525 0.449039906368336 2161 6465167
SGTC_2786 7743617 45.45 µM 0.126560183953698 0.462020053514594 no 1526 0.449644256030157 2028 583674
SGTC_2009 4012297 12.05 µM 0.126304840806454 0.462118504981048 no 1527 0.449745312269803 2053 45595307
SGTC_1218 1348-1416 30.7 µM 0.126005698785633 0.462233846726844 no 1528 0.449863706777505 2130 6787668
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.125850771000125 0.462293584288355 no 1529 0.449925025892053 1974 641818 YHR062C RPP1
SGTC_1067 clotrimazole 1.36 µM 0.123522243018148 0.463191527414102 no 1530 0.450846780891895 2081 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2299 7976368 114.88 µM 0.122243930558925 0.463684559185081 no 1531 0.451352917884524 2163 2979718
SGTC_701 4424-0219 185 µM 0.122042272506575 0.463762341703816 no 1532 0.451432769926688 2195 2911779
SGTC_991 3996-0057 64.7 µM 0.120455878279134 0.464374285694028 no 1533 0.452061014559151 2124 715343
SGTC_48 0382-0018 55 µM 0.119473702025037 0.464753197825344 no 1534 0.452450036765926 2195 762596
SGTC_2460 5552655 174.22 µM 0.119214687226626 0.464853128050788 no 1535 0.452552635453649 2064 5401989
SGTC_1649 st011737 51.3 µM 0.118486175869966 0.465134206112322 no 1536 0.452841223996667 2072 1761035
SGTC_1108 betulinic acid 729.144 nM 0.114921898945056 0.466509642240843 no 1537 0.454253513622774 2093 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3334 9142812 21.919 µM 0.114899366789036 0.46651833857376 no 1538 0.454262443500349 2167 45283678
SGTC_1910 st062352 60.4 µM 0.114168052622612 0.466800599466694 no 1539 0.454552288299136 2149 2245730
SGTC_3307 9126885 69.2785 µM 0.114041423117752 0.466849475588462 no 1540 0.454602478362134 2083 24824909
SGTC_2034 5197015 53.07 µM 0.113550547795449 0.467038947066768 no 1541 0.454797045417872 2181 780676
SGTC_706 4262-0057 46.9 µM 0.112539028454152 0.467429403858091 no 1542 0.45519801302366 2182 883298
SGTC_2815 7968870 71.43 µM 0.111128220602862 0.46797404234908 no 1543 0.455757335265654 2142 2977326 YHR190W ERG9
SGTC_458 nppb 133 µM 0.107876048917436 0.469229760996614 no 1544 0.457047008212583 2219 4549 A chloride channel blocker.
SGTC_2874 9043904 71.43 µM 0.107810739495627 0.469254981249421 no 1545 0.457072911831323 2080 4463428
SGTC_346 4513-0042 7.16 µM 0.107533056362686 0.469362214302332 no 1546 0.457183051084029 2177 2827372
SGTC_409 arachidonic acid 100 µM 0.107492906966816 0.469377719001377 no 1547 0.457198976070304 2218 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3304 9125678 46.087 µM 0.107277396771498 0.469460944476777 no 1548 0.457284457905365 2140 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1229 0139-0193 12.2 µM 0.107272343649178 0.469462895901674 no 1549 0.457286462243404 2233 3090752
SGTC_1312 1218-2183 165 µM 0.106935341291223 0.469593041800562 no 1550 0.457420137817135 2217 6744073
SGTC_900 1112-0045 141 µM 0.106771460904948 0.469656331435237 no 1551 0.457485144459231 2209 56211 YIL048W NEO1
SGTC_1682 st012968 530 nM 0.106481696480062 0.469768238615311 no 1552 0.457600088466281 2038 24207270
SGTC_1955 wogonin 32.4 µM 0.106097472025572 0.469916629991812 no 1553 0.457752508428685 2186 5281703 A flavanone.
SGTC_882 0843-0131 351 µM 0.105505623683976 0.470145215984313 no 1554 0.457987303921267 2232 5425421
SGTC_327 1273-0057 3.96 µM 0.105162132681054 0.470277884946229 no 1555 0.458123578902868 2221 3108138
SGTC_2159 5658611 73.75 µM 0.105146959969944 0.470283745286055 no 1556 0.458129598565522 2228 793844
SGTC_1474 0330-0125 5.35 µM 0.104487332016314 0.470538527578107 no 1557 0.458391310418638 2221 X1474
SGTC_1617 st002906 78 µM 0.103918833886903 0.470758120518452 no 1558 0.458616880374192 2190 5150859
SGTC_1776 st049249 45.9 µM 0.10360490900002 0.470879383640043 no 1559 0.458741445906743 2079 1822314
SGTC_1635 st007035 42.4 µM 0.102548895089611 0.471287321175137 no 1560 0.459160502355689 2217 3716403
SGTC_1622 st003707 19.4 µM 0.102463028679914 0.471320492647523 no 1561 0.459194578598281 2144 10140899
SGTC_481 bay k-8644 50 µM 0.102253195873117 0.471401555021368 no 1562 0.459277852394535 2092 2303 A calcium channel antagonist.
SGTC_2924 9010168 62.78 µM 0.100846546796638 0.471945000539779 no 1563 0.459836138078853 2141 2993929
SGTC_2949 9072542 2.23 µM 0.100486462345134 0.472084124187349 no 1564 0.459979064960212 2140 16457352
SGTC_944 3370-0224 231 µM 0.0997387421643107 0.472373027163309 no 1565 0.460275871039941 2143 4580514
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0992583774061472 0.472558637439581 no 1566 0.460466562590426 2161 390807
SGTC_2806 7952793 58.44 µM 0.0988841658837757 0.47270323482605 no 1567 0.460615120538963 2168 2972490
SGTC_2100 5377183 190 µM 0.0986004208971129 0.472812877845485 no 1568 0.460727767911639 2181 2844202
SGTC_646 4092-0839 27.3 µM 0.0982362325555964 0.472953608316573 no 1569 0.460872356087262 2199 877796
SGTC_738 1315-0003 72.4 µM 0.0977261383268355 0.473150725737878 no 1570 0.461074879757674 2223 6251474
SGTC_715 0868-0130 184 µM 0.0974432115447457 0.473260060919754 no 1571 0.461187215065963 2242 2876258
SGTC_1679 SEC14.276 6.7 µM 0.0968642236334797 0.473483813235575 no 1572 0.461417110283514 2238 1005053 YMR079W SEC14
SGTC_1903 st060211 78.3 µM 0.0965927142573813 0.473588742062757 no 1573 0.461524921309876 2231 688960
SGTC_1058 3448-5425 97.3 µM 0.0965030786693294 0.473623383468518 no 1574 0.461560514457879 2222 7279705
SGTC_1900 st060200 72.8 µM 0.0957679114164755 0.473907510568055 no 1575 0.461852451583542 2182 688945
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0937934646147775 0.474670659147957 no 1576 0.46263661164074 2172 676296 Flavone; oxidizing agent.
SGTC_2150 5556613 200 µM 0.09365328954113 0.474724842147607 no 1577 0.462692288332425 2163 743190
SGTC_3224 9130643 49.47 µM 0.0933931521851547 0.474825396371995 no 1578 0.462795615253349 2195 17644395
SGTC_1946 st076057 65.1 µM 0.0918990090077421 0.475402977534728 no 1579 0.463389139414305 2245 953009
SGTC_488 nitrendipine 139 µM 0.0913384314663135 0.475619689731494 no 1580 0.463611840853143 2267 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2813 7971799 71.43 µM 0.0906480265888313 0.475886601441158 no 1581 0.463886134645737 2177 2234054
SGTC_1434 4073-0095 163 µM 0.0905228597013492 0.47593499233669 no 1582 0.463935864555172 2243 24133745
SGTC_1993 st073995 70.8 µM 0.0893921824355552 0.47637214060349 no 1583 0.464385118056157 2164 3098394
SGTC_742 0kpi-0133 140 µM 0.0889868538170619 0.47652885779318 no 1584 0.46454617890178 2233 2728852
SGTC_3042 9091578 49.47 µM 0.0884606446271706 0.476732317937501 no 1585 0.464755281354572 2233 25236497
SGTC_2297 7971671 152.32 µM 0.0883218047948949 0.476786001731301 no 1586 0.464810454478241 2217 909016
SGTC_237 nikkomycin 200 µM 0.0876363897213271 0.477051030401088 no 1587 0.465082839309765 2240 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1822 st052468 42 µM 0.0875574584573544 0.477081551317487 no 1588 0.465114207748557 2214 2873678
SGTC_22 0964-0034 14.468 µM 0.0867820803008363 0.477381379454183 no 1589 0.465422365863616 2183 138402
SGTC_1355 1499-0035 1.68 µM 0.0863516445950437 0.47754782859684 no 1590 0.465593442652458 2212 1548538
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0859040757513916 0.47772090726352 no 1591 0.465771335754721 2176 4330530
SGTC_1610 st001799 48.1 µM 0.0847586498741065 0.478163872223579 no 1592 0.466226633906893 2100 621897
SGTC_314 1671-0008 2.74 µM 0.0844500506711623 0.478283219923259 no 1593 0.466349307347698 2195 3913060
SGTC_2909 7941780 10.49 µM 0.0839668371047416 0.478470101914795 no 1594 0.466541399390846 2253 1243215
SGTC_484 loperamide 105 µM 0.0833250035725304 0.478718337210164 no 1595 0.466796559723786 2262 3955 An opioid-receptor agonist.
SGTC_2186 6124449 200 µM 0.083322432576028 0.478719331584469 no 1596 0.466797581848602 2224 3834182 YLR033W RSC58
SGTC_2699 st077704 54.6 µM 0.0829993953322257 0.478844272493115 no 1597 0.466926010205648 2181 645852
SGTC_2076 5212012 200 µM 0.0825725838042359 0.479009353301392 no 1598 0.467095700881963 2268 604802
SGTC_396 dithiazanine 1.25 µM 0.082014495381223 0.479225214398682 no 1599 0.467317593320771 2124 10578 An antihelmenthic.
SGTC_334 1502-1024 68.5 µM 0.0818179664927347 0.479301230583943 no 1600 0.467395734389486 2170 3296216
SGTC_1708 st033234 31.827 µM 0.0814939922248921 0.479426543513225 no 1601 0.46752455124944 2237 674664
SGTC_2037 5169046 200 µM 0.081203884937688 0.479538758453753 no 1602 0.46763990499425 2198 5718022
SGTC_3229 9132204 49.47 µM 0.0805961626907758 0.479773833685691 no 1603 0.467881559004015 2182 17682924
SGTC_3072 9116419 49.47 µM 0.0784125190603403 0.48061855421655 no 1604 0.468749957711778 2189 17170162
SGTC_1827 berberine 7.24 µM 0.0781514301356242 0.480719559735815 no 1605 0.468853798462987 2185 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_713 1488-1073 324 µM 0.0769643891013889 0.481178796932299 no 1606 0.469325937143689 2282 3312542
SGTC_3099 9120367 49.47 µM 0.0768702179022652 0.481215230547619 no 1607 0.469363395046987 2274 24824940
SGTC_1228 0124-0032 52.5 µM 0.0764535189983076 0.481376447827056 no 1608 0.469529146077563 2224 X1228
SGTC_1143 3454-2408 5.08 µM 0.0763148648439639 0.481430092622602 no 1609 0.469584299948255 2277 X1143
SGTC_1568 digitonin 820 nM 0.0757528460730789 0.481647539105209 no 1610 0.469807865826889 2286 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_686 1319-0111 510 µM 0.0753050304837182 0.481820804000034 no 1611 0.469986009551302 2252 4562600
SGTC_1748 st037455 53.6035 µM 0.0751266799345017 0.481889810794076 no 1612 0.470056960143074 2225 580690
SGTC_2930 9013230 14.89 µM 0.0745883620485401 0.482098098220234 no 1613 0.470271117034162 2244 2995857
SGTC_2996 9066192 71.4286 µM 0.0725249595124011 0.482896520328561 no 1614 0.471092071474443 2181 6472854
SGTC_17 0960-0276 49.807 µM 0.071956807511046 0.483116375758023 no 1615 0.471318140657405 2292 6821114
SGTC_1781 st038725 66.3 µM 0.0719346204709752 0.48312496148972 no 1616 0.471326969127273 2132 4270275 YIL048W NEO1
SGTC_553 k007-0256 45.7 µM 0.0702354741097644 0.48378250408674 no 1617 0.472003119887049 2208 6287000
SGTC_358 0075-0058 9.45 µM 0.0697499878746963 0.483970387712342 no 1618 0.472196327031583 2324 1069125
SGTC_2022 5136654 200 µM 0.0697000250885791 0.483989723559851 no 1619 0.472216210907126 2221 1713771
SGTC_141 0443-0274 32.331 µM 0.0695428547158152 0.484050549523589 no 1620 0.472278761035368 2279 1627241
SGTC_1279 0874-0590 65.2 µM 0.0691923568498011 0.484186195828225 no 1621 0.472418253439259 2228 3523074
SGTC_499 genistein 192 µM 0.0686938203103036 0.484379137782028 no 1622 0.472616668631827 2287 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_431 k089-0097 107 µM 0.0679105854905161 0.484682270087267 no 1623 0.472928406102822 2294 5499420
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0675235308425001 0.484832073611281 no 1624 0.473082464934448 2197 6857784
SGTC_1738 st035555 74 µM 0.066302693193954 0.485304593895104 no 1625 0.473568419543238 2238 5331140
SGTC_1417 3966-0327 90.4 µM 0.0661215529005262 0.48537470528854 no 1626 0.473640525832894 2230 651118
SGTC_574 1315-0397 40 µM 0.0654564277406544 0.485632149672359 no 1627 0.473905298761664 2286 6794277
SGTC_429 1112-0049 25.5 µM 0.0627401317035654 0.48668358448483 no 1628 0.474986719923945 2131 2836170
SGTC_1976 st070609 63.5 µM 0.0626647132770758 0.486712779107811 no 1629 0.475016748434974 2284 682556
SGTC_297 0986-0032 24 µM 0.0625613039109404 0.486752809194959 no 1630 0.475057922015919 2267 2847425
SGTC_1848 st056003 16.4 µM 0.0615033821218593 0.487162341605101 no 1631 0.475479160481918 2316 146492
SGTC_1367 1812-0510 76.9 µM 0.0603375263835429 0.487613672020931 no 1632 0.475943407322685 2262 1142582 YDR527W RBA50
SGTC_2877 9040724 71.43 µM 0.0602960269007907 0.48762973775108 no 1633 0.475959933132224 2307 6463895
SGTC_2131 toluylene red 5.2905 µM 0.0599764885710467 0.487753441567581 no 1634 0.476087180187299 2234 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2070 5230947 200 µM 0.0577673970836449 0.488608685262424 no 1635 0.476966954075873 2304 2835538
SGTC_821 1114-0266 29.2 µM 0.0575909967814686 0.488676980464811 no 1636 0.477037210649403 2243 3123235
SGTC_2971 9092186 9.93 µM 0.0574863490036424 0.488717496091932 no 1637 0.477078890021447 2133 25236400
SGTC_142 0335-0849 62.6745 µM 0.0564100560529134 0.489134202342033 no 1638 0.477507573070514 2300 3889043 YPR107C YTH1
SGTC_496 calpeptin 138 µM 0.0561234729996095 0.489245160164198 no 1639 0.477621722328488 2204 73364 A calpain inhibitor.
SGTC_2635 hydroquinidine 100 µM 0.0559379452237002 0.489316992343674 no 1640 0.477695621110879 2283 442912 An experimental heart treatment.
SGTC_1384 3089-0840 101 µM 0.0550578163924368 0.489657763101021 no 1641 0.478046201390417 2297 1069836
SGTC_557 1315-0110 16.2 µM 0.0535607129424863 0.490237433036767 no 1642 0.478642579043461 2315 6833801
SGTC_1715 st032160 10.2275 µM 0.0535118724272536 0.490256344160283 no 1643 0.478662035687313 2288 5289825
SGTC_1472 k841-0093 193 µM 0.0506713814640034 0.491356222969401 no 1644 0.479793690813301 2301 X1472
SGTC_474 dl-dihydrosphingosine 5 µM 0.0488859458849211 0.492047603383639 no 1645 0.480505094515043 2297 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_5 0352-0601 109.883 µM 0.0487211727155189 0.492111410305592 no 1646 0.480570751262136 2251 762456
SGTC_2018 5133068 143 µM 0.0486778759807978 0.492128176608698 no 1647 0.480588003689778 2318 785362
SGTC_1632 st005650 90 µM 0.0476695611899931 0.492518642058858 no 1648 0.480989796582365 2269 2759605
SGTC_414 piperonyl butoxide 100 µM 0.0475522418714505 0.492564073919617 no 1649 0.48103654720167 2302 5794 A potent inhibitor of cytochrome P450.
SGTC_2680 butyl paraben 22.24 µM 0.0461742127885165 0.493097722211895 no 1650 0.481585697879926 2325 7184 An antifungal and steroid mimetic.
SGTC_1438 4092-1045 4 µM 0.0445476794775587 0.493727620765765 no 1651 0.482233923474099 2329 1351342
SGTC_2065 5221596 34.26 µM 0.0444367378030718 0.493770585121608 no 1652 0.48227813901344 2291 788581
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0441610612463785 0.49387734662784 no 1653 0.482388010189181 2281 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2749 bexarotene 57.39 µM 0.0441423405665545 0.493884596618217 no 1654 0.482395471384011 2274 82146 An retinoic acid receptor inhibitor.
SGTC_404 fumagillin 50 µM 0.0438514629090145 0.493997245574798 no 1655 0.482511402519766 2222 12015870 A methionine aminopeptidase binder.
SGTC_522 1273-0010 11.6 µM 0.0423675626682768 0.494571926788274 no 1656 0.483102843180504 2268 5705015
SGTC_1844 rapamycin 4 nM 0.0419497007044392 0.49473375741999 no 1657 0.483269397905214 2287 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_367 0335-0881 7.1 µM 0.04192799838972 0.494742162370891 no 1658 0.483278048265375 2300 23828853
SGTC_682 0kpi-0099 17 µM 0.0402528900395383 0.495390911145367 no 1659 0.483945755807591 2278 1714895 YML126C ERG13
SGTC_2937 9044753 11.33 µM 0.039954825258146 0.495506349280502 no 1660 0.484064570866039 2334 6465530 YGL099W LSG1
SGTC_411 enrofloxacin 100 µM 0.0398081280267764 0.49556316409808 no 1661 0.484123048070563 2330 71188 A bacterial gyrase inhibitor.
SGTC_1202 1988-0068 29.6 µM 0.0395943548641853 0.495645957118187 no 1662 0.484208264038685 2290 2850480
SGTC_3014 9081533 49.47 µM 0.0392948650065274 0.495761947997312 no 1663 0.484327650293697 2334 21367265
SGTC_985 1493-0307 8.71 µM 0.0391284375159325 0.495826404662609 no 1664 0.484393994232948 2335 3278274
SGTC_1651 st011928 86.1 µM 0.0389807081214905 0.495883619725449 no 1665 0.484452884805558 2309 720198
SGTC_2282 7944268 200 µM 0.038214747833477 0.496180274719905 no 1666 0.484758231207178 2305 2970414
SGTC_726 3448-4391 34.2 µM 0.0378062304596606 0.496338493612848 no 1667 0.484921088368444 2306 1356692
SGTC_2341 7987486 176.74 µM 0.0375469456787389 0.496438914981251 no 1668 0.48502445463837 2332 1258686
SGTC_684 1140-0066 328 µM 0.0350969413611534 0.497387815430701 no 1669 0.486001220175764 2287 6813534
SGTC_1350 1495-0454 146 µM 0.0337890758476963 0.497894365490607 no 1670 0.486522673591739 2331 1069057
SGTC_806 3966-4455 5.86 µM 0.0337122017408308 0.497924139753803 no 1671 0.486553324460967 2210 714982
SGTC_3168 9103419 49.47 µM 0.032908831725089 0.498235295252687 no 1672 0.486873644956844 2350 16649256
SGTC_2289 7946404 165.07 µM 0.0327836443640967 0.498283782022819 no 1673 0.486923560554466 2320 1246120 YPR165W RHO1
SGTC_3012 9080433 71.4286 µM 0.0316912326880218 0.498706888942628 no 1674 0.487359143338956 2344 17688859
SGTC_1719 st032227 49.2 µM 0.031537732831937 0.49876634179541 no 1675 0.487420350326437 2341 3125804
SGTC_2691 st077356 60.2 µM 0.0301151756865905 0.499317321165751 no 1676 0.487987598886431 2337 2839272
SGTC_453 enantio-paf c16 10 µM 0.0300498989193635 0.499342603951812 no 1677 0.488013628768148 2345 13871343 A lipid and platelet activating factor
SGTC_2172 5754775 163.918 µM 0.0284010770567913 0.499981220898664 no 1678 0.488671132590973 2332 2263357
SGTC_1587 estradiol valerate 56.1 µM 0.0283041069447979 0.499981220898664 no 1679 0.488709802522655 2357 13791 A steroid.
SGTC_1323 1348-1351 11.2 µM 0.0275976959440758 0.499707615718043 no 1680 0.488991509668572 2246 6989654
SGTC_62 0180-0423 3.232 µM 0.0266971852704314 0.499358832598398 no 1681 0.489350629081181 2329 30102 YGL099W LSG1
SGTC_1531 st059297 52.4 µM 0.026466786867829 0.499269595441483 no 1682 0.489442512276953 2347 7566702
SGTC_2147 5545932 89.7195 µM 0.0263540350895211 0.499225924803949 no 1683 0.48948747804372 2327 797404
SGTC_3114 9122766 49.47 µM 0.0256722069624051 0.498961841655575 no 1684 0.489759396089676 2258 17176985
SGTC_957 1187-1561 14.1 µM 0.0254833516137684 0.498888694975964 no 1685 0.489834713831693 2357 1538454
SGTC_288 1315-0019 35.1 µM 0.025171986378607 0.498768098351945 no 1686 0.489958890752579 2346 6811474
SGTC_3209 9113616 49.47 µM 0.0244806769247537 0.498500343809753 no 1687 0.490234598338245 2369 16649353
SGTC_114 0364-0001 490.298 µM 0.0237430263761702 0.498214641412995 no 1688 0.490528792791547 2289 4003655
SGTC_1239 0337-0584 35.4 µM 0.0210590383031883 0.497175104026879 no 1689 0.491599280170391 2358 914301 YML130C ERO1
SGTC_402 epigallocatechin gallate 10 µM 0.019976988675136 0.496756019620982 no 1690 0.492030864639771 2336 65064 An antioxidant.
SGTC_1711 st032263 62.8 µM 0.0193674661643187 0.49651994938985 no 1691 0.492273981889112 2321 3958979
SGTC_612 0302-0167 22.4 µM 0.018915899370389 0.496345056749555 no 1692 0.492454097973454 2348 235821
SGTC_91 0417-1751 58.384 µM 0.0188203728414533 0.496308059240107 no 1693 0.492492200761707 2366 6795624
SGTC_3152 9099253 49.47 µM 0.0168869159223465 0.495559236923366 no 1694 0.493263415430826 2351 25236131
SGTC_2118 5526350 200 µM 0.0159826623626391 0.495209027323862 no 1695 0.493624111679977 2363 743594
SGTC_2171 5739187 198.077 µM 0.0154720102150564 0.495011257768312 no 1696 0.493827807216501 2372 2262761
SGTC_606 k015-0008 38.6 µM 0.0139536088516521 0.494423206256157 no 1697 0.494433496101499 2376 1970475
SGTC_2947 9072639 7.68 µM 0.0138391965823906 0.494378896768352 no 1698 0.494479135586146 2378 16488146
SGTC_276 colchicine 750 µM 0.0137820694714661 0.494356772654609 no 1699 0.494501923832702 2318 2833 A microtubule depolymerizer.
SGTC_1627 st003713 25.6 µM 0.0132618125627159 0.494155289038178 no 1700 0.494709457334053 2363 16195070 YER133W GLC7
SGTC_1999 st074831 12.5 µM 0.0125623557638357 0.493884407756914 no 1701 0.49498847695844 2368 17112523
SGTC_1852 st056254 31.4 µM 0.0125490243167895 0.493879244863959 no 1702 0.494993795017126 2325 442583
SGTC_960 1222-0186 7.7 µM 0.0119959503908565 0.493665055865367 no 1703 0.495214422972107 2373 3126296
SGTC_1729 st035615 45.989 µM 0.0115627074615362 0.493497275102235 no 1704 0.495387249902439 2260 17385451
SGTC_223 busulfan 5 mM 0.0114771513092712 0.493464142148354 no 1705 0.495421379604185 2370 2478 A DNA alkylator.
SGTC_3319 9138450 16.7555 µM 0.0106104572180475 0.493128503929944 no 1706 0.4957671194257 2376 2029690
SGTC_3013 9080133 71.4286 µM 0.0104233741588585 0.493056054285826 no 1707 0.495841750640422 2381 17050193
SGTC_1214 0358-0031 63.7 µM 0.0103897407321505 0.493043029454639 no 1708 0.49585516770984 2379 4301366
SGTC_1392 3455-1037 33.9 µM 0.00892437668792317 0.492475562130096 no 1709 0.496439736072261 2378 981132
SGTC_1524 corynanthine 62.1 µM 0.00856044453294945 0.492334630452803 no 1710 0.496584918447045 2342 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1667 st014849 34.6 µM 0.00850615238755856 0.49231360605769 no 1711 0.496606577090757 2387 5348460
SGTC_220 paclitaxel 373.376 µM 0.00845208709299902 0.492292669530785 no 1712 0.496628145247316 2379 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1940 st075990 51.1 µM 0.00821691516734878 0.492201600574412 no 1713 0.496721962012909 2357 1084979
SGTC_2819 7996655 46.38 µM 0.00748570023974817 0.491918444477179 no 1714 0.497013665566207 2391 6456960
SGTC_727 3032-0951 202 µM 0.00725645377963416 0.491829671775348 no 1715 0.49710511918708 2381 3652836
SGTC_2701 st077767 14.721 µM 0.00700699338763421 0.491733071951934 no 1716 0.497204636953634 2384 5721188
SGTC_318 1488-0629 67.2 µM 0.00642576560588642 0.491508002035996 no 1717 0.49743650805717 2377 3662576
SGTC_1151 3909-8316 15.3 µM 0.00632039121694216 0.491467198002621 no 1718 0.497478545502464 2354 800431
SGTC_2960 9079389 5.97 µM 0.00336023549207128 0.490320977526137 no 1719 0.498659462512817 2400 16457355
SGTC_1274 0865-0114 173 µM 0.00249013195337097 0.48998407405007 no 1720 0.499006582106679 2398 870624
SGTC_630 4356-0227 183 µM 0.00206072627176103 0.48981781109176 no 1721 0.499177889743722 2402 779312
SGTC_1183 1254-0324 198 µM 0.00170357372013038 0.489679525400312 no 1722 0.499320372743991 2403 5799357
SGTC_710 3448-4187 58 µM 0.00130367938504917 0.489524692015211 no 1723 0.499479907320539 2402 3946412
SGTC_1385 3091-4834 14.1 µM 5.49768238110499e-05 0.489041222453633 no 1724 0.499978067420551 2402 4072814
SGTC_2977 9011197 71.43 µM -0.000129399206775314 0.488969837546471 no 1725 0.499948377185511 2407 2704722
SGTC_1320 1313-0481 95.3 µM -0.00242236768022102 0.488082098702109 no 1726 0.499033616058784 2402 6813365 YLR208W SEC13
SGTC_2139 5578692 56.4705 µM -0.0026275693686682 0.488002656241026 no 1727 0.498951752690355 2411 650991 YMR113W FOL3
SGTC_3068 9116768 49.47 µM -0.00518833268483037 0.48701131490222 no 1728 0.497930164013485 2419 41904888
SGTC_2695 st077686 51.995 µM -0.00631534568010392 0.486575042496638 no 1729 0.497480558340264 2423 2876092
SGTC_1974 st069448 26.9 µM -0.00643452921571567 0.486528906880124 no 1730 0.497433011954957 2420 6323587 YNR016C ACC1
SGTC_2441 5730946 39.09 µM -0.00743781893013837 0.48614054341812 no 1731 0.497032766913281 2421 1774275
SGTC_14 0354-0009 295 µM -0.00753002592467146 0.486104851662271 no 1732 0.496995982674766 2425 1713507
SGTC_1495 4469-0029 237 µM -0.00806753799682031 0.485896792126252 no 1733 0.496781552906557 2413 793680
SGTC_1336 1486-0901 104 µM -0.00856090064552463 0.485705825274422 no 1734 0.496584736491121 2451 5006114
SGTC_102 gallobenzophenone 83.616 µM -0.00858685174030401 0.485695780423436 no 1735 0.496574383882715 2430 70837
SGTC_93 0109-0045 59.227 µM -0.00897432139299777 0.485545804214249 no 1736 0.496419811815618 2417 88733
SGTC_1281 0884-0031 11.8 µM -0.0102246743998369 0.485061849513901 no 1737 0.495921016150883 2423 1548255
SGTC_1362 1611-0397 101 µM -0.0111703814592639 0.484695823960276 no 1738 0.495543755221003 2425 27816
SGTC_1144 3486-0183 12.5 µM -0.0112083909778189 0.484681113060146 no 1739 0.495528592566224 2434 6744069
SGTC_1980 st071811 45.7 µM -0.0116386881050012 0.484514575759687 no 1740 0.495356940050836 2467 4974850
SGTC_834 0312-0008 75.7 µM -0.0129366874899563 0.484012229339464 no 1741 0.494839152343741 2428 6385573 YIL048W NEO1
SGTC_3227 9130768 49.47 µM -0.0130615403895324 0.483963910605407 no 1742 0.494789347451419 2435 17720899
SGTC_1498 4478-3555 97.6 µM -0.0133583714147336 0.483849036371741 no 1743 0.494670939337499 2423 3437919
SGTC_1097 itavastatin 7.23 µM -0.0139333314422907 0.483626529448456 no 1744 0.494441584831085 2443 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_988 1497-1057 103 µM -0.0142217502680904 0.483514914586948 no 1745 0.494326533768219 2429 3533044
SGTC_1608 st001473 40.5 µM -0.0151602730628812 0.483151725743241 no 1746 0.49395215776018 2436 7292267
SGTC_2116 5511452 16.8835 µM -0.0154121016850679 0.48305427565917 no 1747 0.493851704412668 2452 870744
SGTC_312 4092-0653 6.84 µM -0.0170569570053258 0.482417791407192 no 1748 0.493195588622847 2488 1148278
SGTC_1220 1838-0075 193 µM -0.0171138686114193 0.48239576999488 no 1749 0.493172887490534 2448 5529645
SGTC_3274 9138298 49.47 µM -0.0175202573783218 0.482238523237343 no 1750 0.493010786137605 2425 17015756
SGTC_644 1498-1197 63.3 µM -0.0175321604054385 0.482233917559987 no 1751 0.49300603824608 2451 6741615
SGTC_1162 k048-0130 20.1 µM -0.0179510901624849 0.482071821208556 no 1752 0.492838935755797 2440 6797406
SGTC_1014 4130-3005 69.3 µM -0.0180706704489771 0.48202555259067 no 1753 0.492791237860672 2449 743608
SGTC_1396 3511-0007 98.6 µM -0.0181757396898681 0.481984898860782 no 1754 0.492749328181324 2454 X1396
SGTC_1665 st014639 11.4 µM -0.0182356829995847 0.481961705485763 no 1755 0.492725418223436 2444 981133 YIL048W NEO1
SGTC_341 1486-1430 230 µM -0.019264942598726 0.481563472069226 no 1756 0.492314875244457 2448 2054753 YPL210C SRP72
SGTC_567 1080-0542 68.4 µM -0.0196541181358931 0.481412899956289 no 1757 0.49215964606252 2444 5950415
SGTC_1044 1222-0021 1.78 µM -0.0200247832716571 0.481269491987367 no 1758 0.492011801167859 2531 4306703
SGTC_513 4245-1575 41.7 µM -0.0205827953765213 0.481053605252048 no 1759 0.491789232430167 2488 719745
SGTC_2664 lyso-paf C-16 73.48 µM -0.0206325159348127 0.481034369362738 no 1760 0.491769401008667 2448 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2177 5811945 192 µM -0.0206404954464954 0.481031282253414 no 1761 0.49176621832185 2458 5343475
SGTC_2102 5377816 72.7585 µM -0.0206580872010117 0.481024476368608 no 1762 0.491759201723262 2456 1379702
SGTC_629 3448-6466 76.7 µM -0.0210570466627659 0.480870128719896 no 1763 0.491600074543815 2444 573744
SGTC_2929 9013348 24.6 µM -0.0211559375609442 0.480831870694996 no 1764 0.491560631569986 2470 2995952
SGTC_717 1532-0246 73.2 µM -0.0225419898408269 0.480295665943586 no 1765 0.4910078087252 2455 9561992
SGTC_3017 9080681 49.47 µM -0.0225459184311914 0.480294146189061 no 1766 0.49100624184262 2476 16451914
SGTC_1480 1070-0044 41.2 µM -0.0231668902297297 0.480053930129337 no 1767 0.490758574642231 2519 3124987
SGTC_1458 k015-0034 6.33 µM -0.0232975804340099 0.480003374991642 no 1768 0.490706450862605 2462 3598957
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0246551884178296 0.479478228116051 no 1769 0.490164999332898 2476 6708760
SGTC_3052 9092717 49.47 µM -0.0248730356946313 0.479393964213745 no 1770 0.490078117488402 2492 25237534
SGTC_3221 9128209 49.47 µM -0.0254342848854089 0.479176875795474 no 1771 0.489854282281508 2475 16460723
SGTC_1253 0550-0034 176 µM -0.0263180858536982 0.47883503848777 no 1772 0.489501814741094 2483 5969915
SGTC_99 0109-0120 622.8 µM -0.0264970025920278 0.478765838802679 no 1773 0.489430462173092 2456 759414
SGTC_1395 3486-0190 4.35 µM -0.0265061416293606 0.478762304111401 no 1774 0.489426817504808 2437 6748079
SGTC_2082 5219693 150 µM -0.0287809193219084 0.47788254454052 no 1775 0.488519659375623 2451 2834649
SGTC_1373 2887-0003 58.5 µM -0.0288158149625569 0.477869049643988 no 1776 0.488505743800777 2495 776948
SGTC_705 1124-0212 310 µM -0.0289442088037091 0.477819397196217 no 1777 0.488454543425453 2458 9554485
SGTC_2693 st077581 40.7 µM -0.0293241201910352 0.477672479938714 no 1778 0.488303045020687 2452 25238761
SGTC_2013 4024628 200 µM -0.0296015990284092 0.477565176753992 no 1779 0.488192395016747 2504 5230760
SGTC_2636 apigenin dimethyl ether 100 µM -0.0296351351726227 0.477552208181016 no 1780 0.488179021897955 2503 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1762 st045503 25.4615 µM -0.0298086884221118 0.477485094763962 no 1781 0.488109814744196 2481 4645554
SGTC_2920 7982904 15.77 µM -0.0302490863292559 0.477314794810819 no 1782 0.487934200596737 2487 6456808
SGTC_917 harmaline 728.087 nM -0.0310777619886075 0.476994360797511 no 1783 0.48760376223206 2502 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2450 5739737 12.93 µM -0.0311051024595579 0.476983788980141 no 1784 0.487592860232863 2486 2262825
SGTC_871 0574-0004 149 µM -0.031662622998812 0.476768214477019 no 1785 0.487370551228678 2493 9551173
SGTC_89 0302-0250 142.109 µM -0.0325235347381757 0.476435342144574 no 1786 0.487027273974176 2455 4203518 YLR208W SEC13
SGTC_3144 9087057 49.47 µM -0.033935465552354 0.475889453474137 no 1787 0.486464306022468 2451 17249618
SGTC_124 0136-0217 7.121 µM -0.0341559437884854 0.475804214991235 no 1788 0.486376398894127 2487 3976905
SGTC_1824 st053723 68.6 µM -0.0343994844134003 0.475710061709012 no 1789 0.486279297304176 2483 675225
SGTC_369 0957-0393 4.5 µM -0.0350421347180599 0.475461618368666 no 1790 0.486023071421683 2476 6997992
SGTC_2104 5389443 200 µM -0.0354585483447902 0.475300641361279 no 1791 0.485857049601336 2507 2244536
SGTC_3330 9141424 71.43 µM -0.037822463203155 0.474386877316956 no 1792 0.484914617069127 2486 27261020
SGTC_3356 9151811 4.48 µM -0.0393067412324715 0.473813202742036 no 1793 0.484322916022615 2479 1859254 YPR165W RHO1
SGTC_651 3253-0966 34.4 µM -0.0399417254827457 0.473567797366512 no 1794 0.484069792751935 2488 781462
SGTC_1935 st074532 41.6 µM -0.0418567038403615 0.472827767714364 no 1795 0.483306465728642 2611 2829742
SGTC_175 3793-3120 23.7 µM -0.0429728860348404 0.472396470206581 no 1796 0.482861573845293 2504 5322297
SGTC_447 ml7 120 µM -0.0442193377849978 0.47191487426571 no 1797 0.48236478390289 2484 4216 Selective myosin light chain kinase inhibitor.
SGTC_274 sirtinol 40.1 µM -0.0443301175377054 0.471872073880036 no 1798 0.482320632470914 2509 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_337 1315-0038 354 µM -0.0443877457050488 0.47184980903919 no 1799 0.482297664766488 2502 1626437
SGTC_1213 1315-0166 115 µM -0.0447714785463445 0.471701554781429 no 1800 0.482144729555452 2567 768401
SGTC_1658 st012944 20 µM -0.0448022994614546 0.471689647365052 no 1801 0.482132446114938 2519 24207260
SGTC_872 0588-0139 234 µM -0.0448600493263898 0.47166733623039 no 1802 0.48210943039265 2498 2047100
SGTC_1243 0416-0003 5.65 µM -0.044912972489051 0.471646889926294 no 1803 0.482088338364258 2521 2141977
SGTC_1263 0774-1208 64.8 µM -0.0462282043674902 0.47113878814348 no 1804 0.481564181332641 2501 906585
SGTC_1958 st076513 41.9 µM -0.0471652705657529 0.470776808338896 no 1805 0.481190753388043 2496 732122 YGL099W LSG1
SGTC_2243 6634756 200 µM -0.0477439330266965 0.470553288545481 no 1806 0.480960160256593 2536 885676
SGTC_2683 piperine 63.03 µM -0.049120884508658 0.470021451297962 no 1807 0.480411480032307 2493 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1843 st055809 45.5 µM -0.0492137287649585 0.469985592809723 no 1808 0.480374485276032 2598 16413835
SGTC_2543 pimpinellin 60.67 µM -0.0521265476767028 0.468860723353019 no 1809 0.47921392986491 2494 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3281 9140613 49.47 µM -0.0527920191528217 0.468603766804708 no 1810 0.47894881021418 2523 16013766
SGTC_2012 4023501 200 µM -0.0531901706719001 0.468450035973307 no 1811 0.478790193598853 2525 3477460
SGTC_946 3434-1334 87.4 µM -0.0533229242609209 0.468398779346858 no 1812 0.478737307631734 2564 4047976
SGTC_2988 9073640 71.4286 µM -0.0539980608318512 0.468138114872396 no 1813 0.478468354610704 2564 9102229
SGTC_2684 capsaicin 100 µM -0.0546692833914481 0.467878975105326 no 1814 0.478200970527248 2558 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_580 1123-0028 41 µM -0.0548407190963829 0.467812790877428 no 1815 0.478132680024256 2509 1677248 YPR107C YTH1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0572348246228596 0.466888619647203 no 1816 0.477179068789652 2629 61125 An anti-inflammatory.
SGTC_2423 st077119 87.2 µM -0.0574066817721888 0.466822286256438 no 1817 0.477110620248714 2470 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1380 2291-0730 164 µM -0.0591007997962044 0.466168440498711 no 1818 0.47643591080595 2566 2999191
SGTC_1672 st016598 6.51 µM -0.0602153291349959 0.46573833698587 no 1819 0.475992068492264 2585 4665860 YNL267W PIK1
SGTC_3132 9126706 49.47 µM -0.0621899781262883 0.464976406744626 no 1820 0.475205771669582 2671 850858
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0628675503530728 0.464714990854118 no 1821 0.474935987388843 2561 641818
SGTC_2302 7771753 200 µM -0.0630521813051718 0.464643760545292 no 1822 0.474862476137631 2562 2203047
SGTC_70 0141-0289 43.283 µM -0.06314218694129 0.464609036933882 no 1823 0.474826640490388 2628 352408
SGTC_2555 cholic acid 100 µM -0.0636949703836246 0.464395782460435 no 1824 0.474606554834461 2658 6708657 Influences liver metabolism.
SGTC_3272 9137413 49.47 µM -0.0641015649945732 0.464238931682446 no 1825 0.474444677862756 2516 17614870
SGTC_1421 4029-0249 71.4 µM -0.0643759916358918 0.464133070083728 no 1826 0.474335423132143 2561 2894095
SGTC_1272 0839-0021 27 µM -0.0654495418671183 0.463718966593645 no 1827 0.47390803994971 2586 5027250
SGTC_1053 3366-3204 134 µM -0.0656228919235203 0.463652103472516 no 1828 0.473839031637429 2558 3632071 YPR165W RHO1
SGTC_1005 4092-0690 4.4 µM -0.0662494498863949 0.463410441396931 no 1829 0.473589613950212 2547 1529343
SGTC_2921 7974240 10.71 µM -0.0665046815501003 0.463312002951355 no 1830 0.473488015312722 2579 2979074 YDR527W RBA50
SGTC_922 1866-0035 480 µM -0.0667840957160331 0.463204240308143 no 1831 0.473376792459745 2531 3156169
SGTC_1789 tunicamycin 25 nM -0.0686571984565958 0.4624819042977 no 1832 0.472631244225476 2604 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1062 mesoridazine 14.2 µM -0.0703282058295502 0.461837607888 no 1833 0.471966216538677 2523 4078 A neuroleptic.
SGTC_2581 avocatin a 64 µM -0.0714323469865161 0.461411934990782 no 1834 0.471526833091554 2573 6710728 A skin care supplement.
SGTC_1812 st052057 4.327 µM -0.0715290130658494 0.461374669996172 no 1835 0.471488367301316 2522 3645418
SGTC_1286 0929-0070 131 µM -0.0717292867782819 0.461297465101636 no 1836 0.471408674354067 2598 1420408
SGTC_2141 5621638 7.665 µM -0.071928089857994 0.461220828574007 no 1837 0.471329567733455 2629 2856238
SGTC_1947 st076332 61.6 µM -0.073442289297238 0.46063716783724 no 1838 0.470727083221514 2524 24208416
SGTC_692 k241-0027 77.8 µM -0.0738150352934528 0.46049350275781 no 1839 0.470578781614776 2604 3600480
SGTC_7 0192-1582 4.227 µM -0.0738847921966553 0.460466617377879 no 1840 0.470551028420346 2546 252616
SGTC_165 k038-0023 64.381 µM -0.074767722832449 0.460126338036332 no 1841 0.470199761679398 2559 46368543
SGTC_2856 9022925 19.48 µM -0.0761451622606795 0.459595534602547 no 1842 0.469651805061912 2634 4944862
SGTC_1443 4112-3303 14 µM -0.0764356976864362 0.459483584432796 no 1843 0.469536235008999 2540 704433
SGTC_1156 4092-0367 4.88 µM -0.0770334273063196 0.459253275188986 no 1844 0.469298476410598 2569 1357585
SGTC_830 4076-0286 57.8 µM -0.0797379256143224 0.458211385827654 no 1845 0.468222847596973 2581 6866659
SGTC_884 0851-0618 334 µM -0.0806345808926449 0.457866018562681 no 1846 0.467866282080819 2570 9642473
SGTC_1165 k072-0275 30.3 µM -0.080655452972864 0.457857979582009 no 1847 0.467857982358584 2552 6153523 YGL055W OLE1
SGTC_704 1310-0270 142 µM -0.0808168558841359 0.45779581506773 no 1848 0.467793801430534 2622 5718033
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0821266568712311 0.457291382049639 no 1849 0.467272997801714 2530 6708784 An antioxidant flavonoid
SGTC_792 4534-1957 155 µM -0.0827354364328336 0.457056951090885 no 1850 0.467030953627613 2613 1717904
SGTC_1161 k007-0610 110 µM -0.0836946362647569 0.456687609423525 no 1851 0.466649610912296 2574 5843850
SGTC_586 0957-0265 8.15 µM -0.0840052870634468 0.456568000764889 no 1852 0.466526114080495 2542 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2285 7945142 200 µM -0.0840268289553859 0.456559706720496 no 1853 0.466517550386664 2633 2970608
SGTC_669 0108-0021 26.2 µM -0.0856653362730543 0.455928905490113 no 1854 0.465866229221985 2528 17201
SGTC_2993 9054257 71.4286 µM -0.0867602983711317 0.455507422993863 no 1855 0.465431022944285 2565 6470217 YGL055W OLE1
SGTC_263 alizarin 107.927 µM -0.087520277950862 0.455214914340518 no 1856 0.465128983900781 2545 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1260 0700-1617 7.75 µM -0.0882534443879465 0.454932748808418 no 1857 0.464837620253691 2616 2853078
SGTC_94 0334-0113 514.748 µM -0.0888996724122731 0.454684061134399 no 1858 0.464580821949926 2568 6795178
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0905866827682131 0.454034933555145 no 1859 0.463910507016789 2551 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_747 3448-8087 38.7 µM -0.092377513167816 0.453345992475493 no 1860 0.463199052457929 2612 5168703
SGTC_1707 st032323 6.317 µM -0.0926298190455894 0.45324894042445 no 1861 0.463098826706874 2579 3132057 YMR211W DML1
SGTC_876 0720-0963 56.8 µM -0.0928368840032656 0.453169292844561 no 1862 0.463016574166348 2627 765861
SGTC_359 0081-0058 15.9 µM -0.0930674591735276 0.453080604273419 no 1863 0.462924984510394 2789 3494159
SGTC_2654 protoveratrine a 100 µM -0.0931768924608773 0.453038512607133 no 1864 0.462881515828944 2568 5702278 A heart drug and vasodilator.
SGTC_2114 5491910 81.25 µM -0.093213369019322 0.45302448263203 no 1865 0.462867026845178 2650 2849228
SGTC_1052 3253-3998 198 µM -0.0933306101391688 0.452979388588809 no 1866 0.462820457415901 2564 5450317
SGTC_1339 1486-1321 22.7 µM -0.0937258554292507 0.452827371241933 no 1867 0.462663465509113 2591 3469382
SGTC_1702 st027038 51 µM -0.0968355735836692 0.451631569310833 no 1868 0.46142848652041 2639 5521182
SGTC_618 k072-0232 33.2 µM -0.0969970151848596 0.451569500915718 no 1869 0.461364382405541 2626 5872756 YGL099W LSG1
SGTC_1024 4507-0395 26 µM -0.0997455005946096 0.450512991610191 no 1870 0.460273188194722 2738 4201836
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0998047743842672 0.450490210783355 no 1871 0.460249658784435 2568 66535 A nucleotide analog.
SGTC_1129 3453-1384 223 µM -0.099826305656162 0.450481935662331 no 1872 0.460241111733694 2804 1084452
SGTC_3179 9107801 49.47 µM -0.0998772275343686 0.450462364925289 no 1873 0.460220897865007 2604 4818259
SGTC_1224 0823-0416 294 µM -0.100379787003278 0.450269223387685 no 1874 0.460021408170894 2676 3598164
SGTC_2944 9067346 25.62 µM -0.101423142700691 0.449868282980608 no 1875 0.45960728298937 2665 6473075
SGTC_3235 9132602 49.47 µM -0.101484390990643 0.449844748092603 no 1876 0.459582973884575 2675 4912240
SGTC_1523 st012844 44.7 µM -0.101914259355765 0.449679574509352 no 1877 0.459412365783963 2715 4274103
SGTC_2017 5132927 60.65 µM -0.102015318903487 0.449640744427058 no 1878 0.459372257897624 2612 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1597 7-benzyloxygramine 47.5 µM -0.102275034204907 0.449540956300889 no 1879 0.459269185597802 2574 260807
SGTC_3128 9127691 49.47 µM -0.10322883229506 0.44917451427422 no 1880 0.458890678640899 2748 41316314
SGTC_2597 laccaic acid a 100 µM -0.103426946104953 0.449098405870347 no 1881 0.458812063461585 2670 5491415 A textile dye.
SGTC_3318 9139014 38.6185 µM -0.103493559469014 0.449072815763868 no 1882 0.458785630423413 2586 16643984
SGTC_1771 st048882 4.1505 µM -0.103840088158537 0.448939697156464 no 1883 0.458648126332341 2589 4580403
SGTC_2163 5671233 125 µM -0.104839084328607 0.448555966119227 no 1884 0.458251748057059 2619 701023
SGTC_1732 st034308 51.822 µM -0.105246329186638 0.448399550386108 no 1885 0.458090174726925 2559 830119
SGTC_328 k915-0120 63.5 µM -0.10531241994639 0.448374166819904 no 1886 0.458063954043621 2722 6624543
SGTC_2336 9001819 198.65 µM -0.105993060821147 0.448112764487149 no 1887 0.457793928917563 2725 2989602
SGTC_2492 derrusnin 100 µM -0.106713964788819 0.447835923553244 no 1888 0.457507951786669 2578 1715307 Part of coumarin class of compounds.
SGTC_3233 9132340 49.47 µM -0.108635813674637 0.447098021274038 no 1889 0.456745676821837 2606 17682950
SGTC_2094 5332512 191.667 µM -0.108717954520559 0.447066486999191 no 1890 0.456713100309737 2697 755774
SGTC_1668 st014914 51.6 µM -0.108752968804137 0.44705304494519 no 1891 0.45669921396663 2604 2839556
SGTC_2126 5251174 33.877 µM -0.109145950998077 0.446902182465109 no 1892 0.456543364470863 2644 790722
SGTC_1740 st038286 13.222 µM -0.110228997026959 0.446486450253423 no 1893 0.456113883044842 2737 716786
SGTC_1919 st067113 52.3 µM -0.110819133455577 0.446259948388204 no 1894 0.455879886251153 2719 1268243
SGTC_1561 5-methoxyflavone 52.9 µM -0.1108291423926 0.44625610698191 no 1895 0.455875917708775 2580 94525
SGTC_1181 1222-0449 220 µM -0.111293051215391 0.446078065416549 no 1896 0.455691982751023 2721 658318
SGTC_936 3005-4620 401 µM -0.112226155513338 0.445719986304874 no 1897 0.455322045533517 2629 777207
SGTC_2339 9000433 200 µM -0.112666719894809 0.445550934932256 no 1898 0.455147393441719 2673 2988954
SGTC_3259 9138485 49.47 µM -0.113311640374193 0.445303486822203 no 1899 0.454891744496998 2653 17646153
SGTC_259 usnic acid 108.925 µM -0.114914685888635 0.444688510351976 no 1900 0.454256372277491 2788 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1226 3909-7979 35.4 µM -0.117226938734932 0.443801695474414 no 1901 0.453340110033115 2729 6615510
SGTC_548 1436-0017 110 µM -0.118073505225057 0.443477083218171 no 1902 0.453004708172919 2664 9677137
SGTC_1430 4049-0248 69.1 µM -0.118332363805676 0.443377832577322 no 1903 0.452902157464864 2682 22774488
SGTC_2769 toremifene 3.73 µM -0.118570115352082 0.443286677850157 no 1904 0.452807971392194 2747 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_674 0498-0004 451 µM -0.11858019848395 0.443282812010445 no 1905 0.452803976984332 2640 4231473
SGTC_3149 9097855 49.47 µM -0.119305867964005 0.443004606907521 no 1906 0.452516517371829 2725 25236625 YMR079W SEC14
SGTC_650 1328-0195 38 µM -0.119559488485697 0.44290738121164 no 1907 0.452416056479308 2601 2780821
SGTC_845 0330-0138 4.51 µM -0.119620109668571 0.442884142525752 no 1908 0.452392044448438 2601 9039800
SGTC_2628 lathosterol 100 µM -0.120115372429953 0.442694294545131 no 1909 0.452195877559354 2732 6710616
SGTC_1219 1469-0211 33.1 µM -0.120349292467379 0.442604631065962 no 1910 0.452103229047163 2627 6822282
SGTC_2711 st079103 59.1 µM -0.121750656300284 0.442067538469471 no 1911 0.451548246844592 2727 54693780
SGTC_1029 k015-0030 64.7 µM -0.122504601644647 0.441778622197133 no 1912 0.451249700928911 2735 2208316
SGTC_1189 1431-2119 7.28 µM -0.122624581654314 0.441732648007257 no 1913 0.451202194000132 2605 3107275
SGTC_1796 st049173 110.4 µM -0.123345469648504 0.441456433193293 no 1914 0.450916768067648 2604 94134
SGTC_800 3448-7362 155 µM -0.124093719303983 0.441169764622168 no 1915 0.450620535495925 2638 15991913
SGTC_1510 1123-0200 71.5 µM -0.124579324576674 0.440983736555387 no 1916 0.450428298729734 2829 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2337 9009472 200 µM -0.125129757979446 0.440772889555448 no 1917 0.450210412488131 2682 5742383
SGTC_2358 9037157 4 µM -0.12518740330394 0.440750809119115 no 1918 0.450187594748821 2710 2388925
SGTC_3255 9139072 49.47 µM -0.12533521623995 0.440694191767766 no 1919 0.450129086731301 2696 17646060
SGTC_23 0213-0011 39.996 µM -0.126038375329791 0.440424874686044 no 1920 0.449850773828953 2729 627608
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.12745346456614 0.439882964776475 no 1921 0.449290751311178 2648 65057 A dermal irritant. YDR527W RBA50
SGTC_1895 st058434 18.3 µM -0.127484302308776 0.439871156680614 no 1922 0.4492785483742 2649 5393175
SGTC_374 0880-0231 82.3 µM -0.127948252472593 0.439693511746766 no 1923 0.449094962437986 2705 6833587
SGTC_190 3970-0790 3.722 µM -0.128892808013402 0.439331882215392 no 1924 0.448721233786386 2600 2832352
SGTC_2213 7173844 200 µM -0.132145311151244 0.438087028339207 no 1925 0.447434678511399 2653 892728
SGTC_166 k072-0058 166.424 µM -0.132524283643267 0.437942021077171 no 1926 0.447284808424176 2627 5846229
SGTC_584 0986-0246 15.4 µM -0.132605644790202 0.437910890728956 no 1927 0.447252633976718 2637 53315 YDR232W HEM1
SGTC_656 4090-1979 187 µM -0.13308611900524 0.437727059844001 no 1928 0.44706263645901 2680 22330961
SGTC_3328 9140624 29.0385 µM -0.133925053617993 0.437406113172581 no 1929 0.446730919412529 2788 4904392
SGTC_2487 5918373 44.05 µM -0.134447047409691 0.437206437604992 no 1930 0.446524540429485 2623 2876279
SGTC_2837 9008476 45.46 µM -0.135769513089965 0.436700633394361 no 1931 0.446001746440312 2845 2992805
SGTC_1855 st056195 39.6 µM -0.135863258933891 0.436664782285087 no 1932 0.445964690608119 2776 4028379
SGTC_1231 0242-0792 125 µM -0.137512031569128 0.436034329461915 no 1933 0.445313041635022 2635 3707635
SGTC_3097 9117246 49.47 µM -0.137684466168915 0.435968403785988 no 1934 0.445244898333749 2630 16423892
SGTC_2964 9083345 53.42 µM -0.139568326731455 0.435248277252643 no 1935 0.444500533618137 2692 17741579
SGTC_2192 5915882 198.485 µM -0.139573162657266 0.435246428941783 no 1936 0.44449862306259 2647 2876149
SGTC_2069 5228469 200 µM -0.139651236202152 0.435216589105631 no 1937 0.444467778300516 2760 2835210
SGTC_2802 7925815 54.55 µM -0.140105580356988 0.435042945354493 no 1938 0.444288285798604 2663 1262923
SGTC_2741 miltefosine 3.04 µM -0.140112812291052 0.435040181515301 no 1939 0.444285428854155 2681 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1939 st074455 53.6 µM -0.140554894408671 0.434871236355129 no 1940 0.444110791717763 2863 1644229
SGTC_39 0986-0283 58.349 µM -0.140652984954563 0.43483375189187 no 1941 0.444072044160236 2733 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3335 9143315 29.6265 µM -0.141048022597796 0.434682797567485 no 1942 0.44391600249009 2719 4899691
SGTC_2463 5473429 200 µM -0.141580590770868 0.43447930426727 no 1943 0.443705649399505 2719 5399405
SGTC_970 1315-0089 19.5 µM -0.141736072419381 0.434419898292126 no 1944 0.443644240446864 2646 6811083 YLR033W RSC58
SGTC_2342 7990637 118.86 µM -0.14181964520627 0.434387967657065 no 1945 0.443611233140652 2763 2033102 YER133W GLC7
SGTC_1019 4262-0212 3.4 µM -0.143087487996879 0.433903615879087 no 1946 0.443110543195776 2659 4677213
SGTC_1806 st050005 60.3 µM -0.143977119221469 0.433563810804351 no 1947 0.442759268791756 2665 5194765
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.145186333330934 0.433102016073383 no 1948 0.442281878011827 2786 5377381
SGTC_978 1416-0512 87.4 µM -0.146075948714766 0.432762333280072 no 1949 0.441930716439973 2700 6814003
SGTC_3126 9127922 49.47 µM -0.146227099877922 0.432704624000527 no 1950 0.441871056441803 2923 45595682
SGTC_3107 9121808 49.47 µM -0.146415816657911 0.432632574241683 no 1951 0.44179657098815 2649 662681
SGTC_194 1486-1323 56.904 µM -0.150367450817536 0.431124406715756 no 1952 0.440237359875001 2698 5178754
SGTC_1873 rapamycin 2 nM -0.152396211832047 0.43035050508429 no 1953 0.439437222351053 2685 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_148 3253-0744 288.01 µM -0.15312407609304 0.430072915268697 no 1954 0.439150214896184 2652 6893655
SGTC_981 1488-1094 54.9 µM -0.153343948697747 0.429989067968368 no 1955 0.439063522216921 2661 3449522
SGTC_1624 st003710 6.25 µM -0.157890600204167 0.428255938638033 no 1956 0.437271502553037 2849 24207033
SGTC_1309 pyrazolanthrone 13.4 µM -0.159202851688728 0.427755979718513 no 1957 0.436754528597999 2763 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_700 3453-2283 142 µM -0.160574835659073 0.42723338714761 no 1958 0.43621413795337 2847 565664
SGTC_2968 9090663 33.37 µM -0.160920885646134 0.427101595855416 no 1959 0.436077856158866 2791 25236811
SGTC_1047 2043-3044 82 µM -0.161036044668995 0.427057739959236 no 1960 0.436032505785306 2694 669592
SGTC_229 benomyl 22.8748 µM -0.161290871297562 0.426960697793143 no 1961 0.435932156388931 2762 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_173 1273-0061 2.693 µM -0.161347090554579 0.426939289171543 no 1962 0.435910018094037 2803 2847414 YPL266W DIM1
SGTC_1363 1636-0063 10.4 µM -0.161367524996742 0.426931507669879 no 1963 0.435901971368887 2693 6072185
SGTC_746 1095-0025 46.6 µM -0.161846169951023 0.426749246263138 no 1964 0.43571349697227 2838 6749286
SGTC_1809 st050081 57.6 µM -0.162295930734106 0.426577997802223 no 1965 0.43553640950176 2836 5036894
SGTC_2190 6049624 200 µM -0.163159684057964 0.426249158640511 no 1966 0.435196354120594 2666 2265554
SGTC_139 0099-0334 718.624 µM -0.16526005197635 0.425449742815415 no 1967 0.434369650166562 2685 97690
SGTC_1011 4112-3381 17.4 µM -0.165303271375937 0.425433296392773 no 1968 0.434352642028963 2875 2877139
SGTC_2894 9048625 32.47 µM -0.165406012648082 0.425394200433807 no 1969 0.434312210726649 2817 4092861
SGTC_2746 daunorubicin 9.88 µM -0.165882505322612 0.425212891095129 no 1970 0.434124707735738 2666 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2675 theaflavin digallate 100 µM -0.16664884408013 0.424921326153395 no 1971 0.433823179512898 2742 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3050 9093513 49.47 µM -0.167511449319202 0.424593184336723 no 1972 0.433483819778987 2724 25236664
SGTC_885 0865-0106 16.8 µM -0.168756176934068 0.424119772321152 no 1973 0.432994214792371 2701 2793380
SGTC_1164 k060-0068 93.7 µM -0.168823288884326 0.424094250480576 no 1974 0.432967819686639 2696 5963676
SGTC_2721 ifenprodil 61.44 µM -0.168824172708559 0.424093914375329 no 1975 0.432967472080884 2850 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1112 tnp00069 1.16933 µM -0.169170686745255 0.42396214448278 no 1976 0.432831193016951 2825 145826
SGTC_2043 5101342 149 µM -0.169918586788091 0.423677767368447 no 1977 0.432537081769428 2724 678451
SGTC_974 1326-0144 138 µM -0.170217120984828 0.423564265571554 no 1978 0.432419693801543 2723 5411856
SGTC_3278 9139605 49.47 µM -0.170674019988212 0.423390566238555 no 1979 0.432240046053289 2918 7958859
SGTC_3222 9128301 49.47 µM -0.17145636320774 0.423093177339007 no 1980 0.431932469707303 2746 4911358
SGTC_2784 7567673 72.73 µM -0.171601806245782 0.423037895502081 no 1981 0.43187529367063 2670 3471247
SGTC_2271 7849410 118.62 µM -0.172917061872623 0.422538045382461 no 1982 0.431358310118831 2678 972430
SGTC_385 1494-0393 12.4 µM -0.174983987142994 0.421752782796872 no 1983 0.430546107932553 2757 3090647
SGTC_311 1315-0136 58 µM -0.175818137496003 0.421435961787963 no 1984 0.430218409970133 2866 6759207
SGTC_92 0063-0024 660.874 µM -0.176312223396414 0.421248325591721 no 1985 0.430024329790143 2654 3594437
SGTC_1661 st013063 9.66 µM -0.17738848774296 0.420839660756276 no 1986 0.429601624686385 2728 721395
SGTC_794 k038-0031 316 µM -0.178154452221286 0.420548870796678 no 1987 0.429300839636074 2718 6624242
SGTC_266 formosanin C 406 nM -0.178767230787839 0.420316267383831 no 1988 0.429060238396092 2814 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2424 5537928 59.2 µM -0.178809044795864 0.420300396299845 no 1989 0.429043821512851 2742 5382802
SGTC_1886 st057356 49.9 µM -0.178956537762349 0.420244414343149 no 1990 0.428985914272314 2692 24207747
SGTC_68 0986-0284 82.829 µM -0.179595403005618 0.420001947346753 no 1991 0.428735106936299 2937 423278 YIL048W NEO1
SGTC_1369 1866-0067 208 µM -0.180132751848929 0.419798032129947 no 1992 0.428524175441685 2784 3531355
SGTC_2780 5215298 71.43 µM -0.180561768736512 0.419635242597738 no 1993 0.42835578334391 2826 2834131
SGTC_1037 k284-1091 78.7 µM -0.18221938335003 0.419006393768086 no 1994 0.427705280965886 2711 3334711
SGTC_2958 9077254 16.72 µM -0.182300484777655 0.418975631635672 no 1995 0.427673459130898 2908 16457351
SGTC_158 k038-0087 26.446 µM -0.182976848312162 0.418719103246563 no 1996 0.427408092147352 2726 X158
SGTC_416 estradiol valerate 100 µM -0.183552768061438 0.418500698002188 no 1997 0.427182159533663 2797 13791 A steroid.
SGTC_9 0092-0002 10.449 µM -0.183786870488366 0.418411926842509 no 1998 0.427090328260595 2761 759368
SGTC_541 4513-1321 94 µM -0.184970741901613 0.417963068964543 no 1999 0.426625992067399 2761 747515
SGTC_2954 9074818 52.69 µM -0.185393897002214 0.417802658087139 no 2000 0.426460047468049 2865 16648742
SGTC_3270 9137563 49.47 µM -0.186282545610282 0.41746583110979 no 2001 0.426111597239551 2856 17015724
SGTC_1574 spiramycin 23.7 µM -0.189121246635217 0.416390277104673 no 2002 0.424998894780778 2712 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_851 0394-0702 453 µM -0.189742400737684 0.416155011500199 no 2003 0.424755496663202 2772 762646
SGTC_196 k015-0023 18.111 µM -0.190875999082715 0.415725732253807 no 2004 0.424311372199031 2735 5211998
SGTC_1688 st021091 57.6 µM -0.192031664947468 0.41528819982189 no 2005 0.423858700973101 2747 3656366
SGTC_1134 3477-0009 42.5 µM -0.195591660594776 0.413941056024864 no 2006 0.422464894045302 3019 3973534
SGTC_1172 0370-0043 85 µM -0.195865417895172 0.413837504780192 no 2007 0.422357752739076 2900 376585
SGTC_1074 carmofur 3.8 µM -0.197289629266535 0.413298880399464 no 2008 0.421800447252161 2756 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2397 5161689 200 µM -0.198125137199295 0.412982974407107 no 2009 0.421473579004692 2945 2259942
SGTC_1459 k035-0031 35.7 µM -0.198748368600056 0.412747366959508 no 2010 0.421229793012704 2740 3877128 YMR208W ERG12
SGTC_3226 9131256 49.47 µM -0.201037586601203 0.411882217509485 no 2011 0.420334592070116 2753 17178073
SGTC_218 alverine citrate 93.75 µM -0.201919571479874 0.411549008655133 no 2012 0.419989800690181 2873 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_45 0kpi-0036 14.9 µM -0.202724847375472 0.411244835712355 no 2013 0.419675050508918 2884 2795021
SGTC_2254 7938975 95.19 µM -0.202789628253477 0.411220368662723 no 2014 0.419649732481575 2971 2969277
SGTC_1766 st045414 44.774 µM -0.20345142564428 0.410970434616315 no 2015 0.419391104173248 2757 253960
SGTC_852 0418-0143 439 µM -0.203565030484536 0.410927534304875 no 2016 0.419346711262889 2868 5369229
SGTC_1936 st074407 74.3 µM -0.203630896129693 0.41090266211404 no 2017 0.419320973677525 2758 809813
SGTC_2161 5662504 8.5105 µM -0.20379729147359 0.410839829485113 no 2018 0.419255954758056 2800 2859334
SGTC_2225 6654152 15.4 µM -0.20585127525388 0.410064412542066 no 2019 0.418453543474611 2773 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_96 0929-0093 37.281 µM -0.20665466884316 0.409761212045848 no 2020 0.41813978106594 2757 6991579
SGTC_1975 st070967 30.8 µM -0.206668157637782 0.409756121838904 no 2021 0.418134513510932 2865 261391
SGTC_2687 chenodiol 100 µM -0.207902498613591 0.409290388512375 no 2022 0.417652549094633 2870 5702181 A cholesterol synthesis inhibitor.
SGTC_812 4251-0442 148 µM -0.209447971600748 0.40870744146136 no 2023 0.417049273592746 2775 5723007
SGTC_1210 3013-0140 750 nM -0.210998635914484 0.408122739182341 no 2024 0.416444167888874 2934 905973
SGTC_2871 9038510 12.99 µM -0.211550505860558 0.407914697250883 no 2025 0.416228862938698 2826 4945164
SGTC_930 2810-3379 265 µM -0.212267923636765 0.407644286516625 no 2026 0.41594900922037 2991 1015764
SGTC_1837 st055472 66.5 µM -0.212511584732218 0.407552455226759 no 2027 0.41585397043576 2944 676091
SGTC_2183 6420625 130.508 µM -0.212704845609833 0.407479622444426 no 2028 0.415778593501812 2764 2897619
SGTC_2658 polymyxin b sulfate 77.05 µM -0.214161459960154 0.406930782142224 no 2029 0.415210574648439 2801 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2406 ethylparaben 405.7 µM -0.217129433983156 0.405813040494585 no 2030 0.414053738049121 2754 8434 A possible steroid mimic.
SGTC_376 3970-0862 59.1 µM -0.2186244274466 0.405250314684944 no 2031 0.41347131136511 2906 3135186
SGTC_2582 agaric acid 100 µM -0.219399630223038 0.404958600054484 no 2032 0.41316937902566 2909 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2546 rhodinyl acetate 100 µM -0.219692715939866 0.40484832344415 no 2033 0.413055238962614 2816 6708682
SGTC_910 3454-3003 490 µM -0.220205412682268 0.404655434031121 no 2034 0.412855590689104 2882 820824
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.220449732508523 0.404563522913814 no 2035 0.412760458491774 2892 6708739 YPR165W RHO1
SGTC_3253 9135987 49.47 µM -0.220973644609849 0.404366449232722 no 2036 0.412556477144268 2925 4182430
SGTC_1227 3909-8010 46.6 µM -0.221337245401774 0.404229692178323 no 2037 0.412414925711083 2813 15982272
SGTC_69 0096-0274 206.684 µM -0.221339403154972 0.404228880641925 no 2038 0.412414085721985 3091 6741392
SGTC_2752 diclazuril 33.15 µM -0.222547062164058 0.403774741816262 no 2039 0.411944020680551 2962 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2154 5570129 200 µM -0.222925578709557 0.40363242775643 no 2040 0.411796714171413 2780 673366
SGTC_3084 9116877 49.47 µM -0.222938258729575 0.403627660563049 no 2041 0.411791779729029 2781 27241325
SGTC_533 1222-0222 6.71 µM -0.224813673642226 0.402922735668624 no 2042 0.411062114160299 2992 3982874
SGTC_163 TUB2.036 7.546 µM -0.225581658150412 0.402634159033162 no 2043 0.410763403919136 2889 15992207 YJR013W GPI14
SGTC_3035 9091303 49.47 µM -0.229220220323269 0.401267662201396 no 2044 0.409348878692006 2808 25237002
SGTC_3238 9133470 49.47 µM -0.229758582060864 0.401065577386325 no 2045 0.409139685231607 2958 3534688
SGTC_1451 4152-0210 104 µM -0.230192708626106 0.400902638595825 no 2046 0.408971013707847 2980 659563
SGTC_180 1486-1293 102.781 µM -0.231650465628338 0.400355631428018 no 2047 0.408404753770062 2909 4140536
SGTC_2235 salicylic acid 500 µM -0.232048676870849 0.40020624100329 no 2048 0.408250103387438 2818 338 A COX inhibitor and kinase inhibitor.
SGTC_1878 temozolomide 1 mM -0.23330481257966 0.399735092801504 no 2049 0.407762360908024 2867 5394 DNA alkylating agent.
SGTC_372 0155-0182 15.9 µM -0.234729587310084 0.39920086858188 no 2050 0.407209310938522 2814 771486
SGTC_906 1165-0455 526 µM -0.235119314833556 0.399054771726501 no 2051 0.407058063895092 2816 3252859
SGTC_1998 st075797 76.8 µM -0.236266303225412 0.398624883189064 no 2052 0.40661301646474 2811 24208315
SGTC_1506 4226-2149 212 µM -0.237562795779778 0.398139108924363 no 2053 0.406110104562103 2941 991114
SGTC_2974 9094440 9.66 µM -0.239288142387283 0.397492895054912 no 2054 0.405441079689092 3023 25236134
SGTC_2626 ethyl orsellinate 100 µM -0.240128093726408 0.397178400106916 no 2055 0.405115477808885 2815 75653 A natural product.
SGTC_757 1066-0008 322 µM -0.240222475340965 0.397143065875217 no 2056 0.405078895466484 2993 6842497
SGTC_19 0279-0214 38.434 µM -0.241426803504496 0.396692268265472 no 2057 0.404612170425846 2836 3566274 YBR002C RER2
SGTC_1609 st001574 46.4 µM -0.24243542365078 0.396314833208246 no 2058 0.404221394397249 2831 3960012
SGTC_951 1171-0579 82.7 µM -0.242962398394721 0.396117672967403 no 2059 0.404017263243381 2783 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2593 nobiletin 86.24 µM -0.244060384700865 0.395706962129719 no 2060 0.403592026664181 2922 72344 An anti-infammatory.
SGTC_2089 5281248 129.67 µM -0.245728010451906 0.395083394552736 no 2061 0.402946393837959 2851 2737878
SGTC_1892 st058411 7.36 µM -0.245863001716573 0.39503292962438 no 2062 0.402894142587601 2968 3934738
SGTC_1491 4138-0063 26.5 µM -0.247411066596255 0.394454329488435 no 2063 0.402295055230977 2840 23883227
SGTC_1009 4106-0057 9.87 µM -0.247868784448969 0.39428329875402 no 2064 0.402117966370283 2873 2928005
SGTC_2146 5545642 200 µM -0.24851916174517 0.394040314003059 no 2065 0.401866373049803 2856 825326
SGTC_1741 st038134 10.228 µM -0.249746565792598 0.39358186111456 no 2066 0.401391672348211 3073 1272587
SGTC_1365 1672-3266 55.4 µM -0.251612021565958 0.392885369422193 no 2067 0.400670482827054 2965 6415873
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.252771265248165 0.392452723572086 no 2068 0.400222486884659 2826 2333 A French combination drug.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.253648541847595 0.392125400055795 no 2069 0.399883545852933 2874 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_470 aa-861 153 µM -0.253783404505424 0.392075087774731 no 2070 0.399831447544541 2875 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2396 5342950 42.78 µM -0.254269285309043 0.391893838543076 no 2071 0.399643763469118 2949 1886677
SGTC_1646 st011709 75.6 µM -0.255817828673692 0.391316338558989 no 2072 0.399045753294204 2951 5757843
SGTC_2724 maprotiline 69.64 µM -0.255916509129395 0.391279545651904 no 2073 0.39900765329078 2913 4011 A tricyclic antidepressant.
SGTC_1558 st069300 45.6 µM -0.256495295486213 0.391063765346358 no 2074 0.398784206314224 2943 24208000
SGTC_182 3448-4371 550.524 µM -0.256659273303652 0.391002638029069 no 2075 0.398720906862126 2844 3491403
SGTC_965 1291-5240 308 µM -0.257836996593593 0.390563687942895 no 2076 0.398266355211548 2982 2834598
SGTC_919 tnp00227 403.569 nM -0.258447622564124 0.390336155955884 no 2077 0.398030733562042 2889 1269246 A methoxyflavone. YNL221C POP1
SGTC_2318 6029776 164 µM -0.258560726495712 0.390294015189455 no 2078 0.39798709433683 3051 818325
SGTC_2253 7938677 135.83 µM -0.258607431726714 0.390276613922533 no 2079 0.397969074291368 3059 2301972
SGTC_1147 3809-1045 12.3 µM -0.258612201738716 0.390274836740995 no 2080 0.397967233913766 2871 325925
SGTC_1691 st019933 84.6 µM -0.259383471948842 0.389987511845101 no 2081 0.397669690458279 2914 6176082
SGTC_307 1501-1223 22.3 µM -0.260643669642382 0.389518173891025 no 2082 0.397183654910953 2956 2830329
SGTC_2101 5377231 179.231 µM -0.261699579649411 0.389125043214837 no 2083 0.396776532316578 2989 2844213
SGTC_3340 9146634 11.102 µM -0.263069419124519 0.388615201172952 no 2084 0.396248536995678 2950 4907387
SGTC_653 0203-0016 55.2 µM -0.264007257575397 0.388266256620921 no 2085 0.395887163184083 2919 295302
SGTC_2564 betulinic acid 100 µM -0.264206983881621 0.388191955452564 no 2086 0.395810214932381 3166 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_525 k781-2675 26.7 µM -0.264750891596253 0.387989634414052 no 2087 0.395600685023711 2871 3651118 YDL195W SEC31
SGTC_1020 4335-0961 93.3 µM -0.265099130989739 0.387860113406226 no 2088 0.395466548383043 2830 669075
SGTC_1505 k297-0037 20.6 µM -0.266587150150766 0.387306813737176 no 2089 0.394893525193841 2900 4089396
SGTC_1984 st072354 53.1 µM -0.267114489514546 0.387110784637397 no 2090 0.394690505889186 2855 5762938
SGTC_2452 5863136 48.41 µM -0.267519060842177 0.386960411900092 no 2091 0.394534770181722 2835 2184096
SGTC_1896 st058441 89 µM -0.26873314356004 0.38650925856524 no 2092 0.394067522393659 2917 688759
SGTC_1811 st050069 61.5 µM -0.269230248544595 0.386324578489729 no 2093 0.393876252187325 2885 3877702
SGTC_1251 0490-5699 265 µM -0.270616579780671 0.385809677050699 no 2094 0.39334297133861 3046 3883818
SGTC_1731 st035964 63 µM -0.270983235630467 0.385673529897141 no 2095 0.393201963027071 2921 6739575
SGTC_1695 st026914 34.495 µM -0.272208371465581 0.385218713016602 no 2096 0.392730902651723 2866 3289191
SGTC_2902 5787006 60.46 µM -0.272658140127596 0.385051781409409 no 2097 0.392558007580506 2898 591003
SGTC_478 N-arachidonylglycine 10 µM -0.272945775614034 0.384945036684037 no 2098 0.392447449055822 2959 5283389
SGTC_1594 piperine 70.1 µM -0.273952876997873 0.384571358929286 no 2099 0.392060417694249 2874 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2712 st079126 47.7 µM -0.276417013619906 0.383657511455649 no 2100 0.391113895303946 2869 3152970
SGTC_1807 st050092 58.9 µM -0.276616977300948 0.383583381409004 no 2101 0.391037113598907 2904 5008496
SGTC_487 nimodipine 119 µM -0.276989121618196 0.383445432323919 no 2102 0.390894229582655 2965 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1370 2001-0092 44.6 µM -0.27834588956303 0.382942621239523 no 2103 0.390373426289898 3121 790957
SGTC_578 3460-0051 92 µM -0.27890036943948 0.382737190616391 no 2104 0.390160642507161 2980 2876744
SGTC_3075 9116269 49.47 µM -0.279805284749566 0.382401997170125 no 2105 0.389813448475181 3108 17015205 YNL244C SUI1
SGTC_3136 9095672 49.47 µM -0.280017791229388 0.382323294524297 no 2106 0.389731927633664 2804 17217380
SGTC_286 k060-0067 22.9 µM -0.280579055679037 0.382115451317244 no 2107 0.389516641061197 2933 5985051
SGTC_3188 9110789 49.47 µM -0.280929272766644 0.38198577877926 no 2108 0.3893823239878 3066 849217
SGTC_1968 st069590 43.6 µM -0.281204389870472 0.381883922293602 no 2109 0.389276818916476 3055 6384066
SGTC_1102 cgs 12066b 26.1 µM -0.281343631782626 0.381832373936825 no 2110 0.389223423936847 2940 6438352 A 5-HT1B full agonist.
SGTC_948 3448-0295 75.3 µM -0.281994647054187 0.381591391215703 no 2111 0.38897380742213 2881 678569
SGTC_1949 st076024 69.1 µM -0.283240317842851 0.381130416130054 no 2112 0.388496312017294 2839 2921930
SGTC_1261 0712-0010 12.7 µM -0.283373038812474 0.38108131110764 no 2113 0.388445446812994 3083 2840123
SGTC_290 2043-6722 48.1 µM -0.284725600165971 0.380580990425643 no 2114 0.387927187997396 2991 773758 YLR208W SEC13
SGTC_753 1322-0200 289 µM -0.284887156894601 0.380521242940755 no 2115 0.387865297882573 3055 5403907
SGTC_50 0929-0078 56.389 µM -0.285075840778433 0.38045146680262 no 2116 0.387793019341545 2912 1377751
SGTC_2350 9023895 38.85 µM -0.285300632143187 0.380368343034921 no 2117 0.387706914296575 3061 2997209
SGTC_1765 st044815 90.4 µM -0.287169223366269 0.379677586055924 no 2118 0.386991375238803 3002 645695
SGTC_29 0299-0004 12.984 µM -0.287262840971592 0.379642988771043 no 2119 0.386955536356612 2943 16871 A napthoquinone isolated from Swertia calycina.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.288712977292017 0.379107200187854 no 2120 0.386400515488289 2923 1241132 A phosphatase inhibitor.
SGTC_1329 1447-1697 50.6 µM -0.288876172179503 0.379046918332008 no 2121 0.386338069285673 3014 2840515
SGTC_205 1486-1330 71.903 µM -0.289127799122581 0.378953976705193 no 2122 0.386241790500367 2913 4118834
SGTC_3140 9094243 49.47 µM -0.290346833856413 0.378503809815474 no 2123 0.385775456471926 2937 19291112
SGTC_1387 3342-1166 1.8 µM -0.290867607540596 0.378311547976554 no 2124 0.385576288063945 2982 3418228
SGTC_3078 9116413 49.47 µM -0.29180253850192 0.377966461093004 no 2125 0.385218802114365 2832 17177322
SGTC_765 1319-0117 244 µM -0.293080796234118 0.377494808461547 no 2126 0.384730197490087 2906 3487746 YGL099W LSG1
SGTC_1618 st003135 44.5 µM -0.294345726687339 0.377028253117868 no 2127 0.38424686727854 2902 1270615
SGTC_2309 7664088 163.95 µM -0.295201877228722 0.376712573444749 no 2128 0.383919834021723 3104 704922
SGTC_58 0957-0393 9 µM -0.295555624574264 0.376582163837062 no 2129 0.383784733365272 3042 6997992
SGTC_2588 indole-3-carbinol 100 µM -0.296458562856619 0.376249357869141 no 2130 0.383439953707531 3072 3712 Induces cell cycle arrest.
SGTC_3333 9141820 12.094 µM -0.298802126824842 0.375385994320333 no 2131 0.382545514033082 2955 1939433
SGTC_2898 9056270 58.44 µM -0.29898467245148 0.375318771064649 no 2132 0.38247587028153 2923 19154699
SGTC_204 PMA1.184 62.41 µM -0.299825804868798 0.375009069178179 no 2133 0.382155015447216 2935 2252213 YGL008C PMA1
SGTC_848 0368-0089 85.6 µM -0.30181482848854 0.374277038804358 no 2134 0.381396613104944 3059 762535
SGTC_2373 9071805 200 µM -0.302448653650468 0.374043863996388 no 2135 0.381155035007983 3085 10149009
SGTC_942 3253-1115 227 µM -0.302569425187099 0.37399943917628 no 2136 0.381109009017814 3137 46497897
SGTC_805 3852-0218 479 µM -0.304079951820108 0.373443945868654 no 2137 0.380533490111425 2925 6615355
SGTC_842 0271-0008 11.1 µM -0.304869631826684 0.373153647103708 no 2138 0.380232722833631 3063 1221709
SGTC_2864 9034755 47.6 µM -0.305678329977047 0.372856431586472 no 2139 0.379924787109502 2927 4930451
SGTC_3205 9113483 49.47 µM -0.307667798846715 0.372125577545781 no 2140 0.379167562351484 3130 17018033
SGTC_3180 9109287 49.47 µM -0.308343764336663 0.371877358589573 no 2141 0.378910384032319 3067 18891271
SGTC_923 1900-2434 73.3 µM -0.309090743717454 0.371603124798685 no 2142 0.378626250061162 2907 5910570
SGTC_2876 9059903 25.97 µM -0.309502012063514 0.371452166265492 no 2143 0.378469840924135 2918 6916095
SGTC_2722 naftopidil 47.16 µM -0.309657518712308 0.371395091759436 no 2144 0.378410705499968 3064 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2361 9034121 116 µM -0.31044678248516 0.371105457476129 no 2145 0.378110611471692 2970 6496917
SGTC_443 clozapine 122 µM -0.310763824634005 0.370989133799784 no 2146 0.377990086331629 2998 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3193 9111931 49.47 µM -0.311807897500079 0.370606143842436 no 2147 0.377593260869023 2928 17087244
SGTC_961 1252-1571 372 µM -0.312054933880468 0.370515543952541 no 2148 0.377499387524478 3137 6813498
SGTC_1979 st071809 45.3 µM -0.312763395313776 0.370255757579948 no 2149 0.377230213708167 3080 4976333
SGTC_3284 9108171 64.8615 µM -0.314679622122971 0.369553391382139 no 2150 0.376502458991134 3050 8687505
SGTC_879 0831-1030 162 µM -0.314695123537177 0.369547711326011 no 2151 0.376496573567907 2972 1549252
SGTC_2483 5729050 27.16 µM -0.31478722795829 0.369513962845215 no 2152 0.376461604866771 3133 2865180
SGTC_926 2268-1401 59.4 µM -0.314817304136084 0.369502942687417 no 2153 0.376450186254763 2929 2931578
SGTC_330 1488-0319 80.1 µM -0.316751400769167 0.368794499335083 no 2154 0.375716121616319 3028 6846614
SGTC_475 α-linolenic acid 10 µM -0.317082267367455 0.368673350248849 no 2155 0.375590589881882 3190 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1988 st071872 53.4 µM -0.318534040095826 0.368141928063523 no 2156 0.37503993897996 3097 16414116
SGTC_2872 9044037 25.97 µM -0.318788021635519 0.368048983877913 no 2157 0.374943631053635 2946 6465195
SGTC_2753 fluvastatin 17.09 µM -0.319803800699012 0.367677338231715 no 2158 0.37455853313501 3060 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3036 9090181 49.47 µM -0.320904742954674 0.367274673599991 no 2159 0.374141289761986 2942 25236586
SGTC_3207 9114163 49.47 µM -0.321253774537771 0.367147047325446 no 2160 0.374009041896432 3230 849233
SGTC_466 geldanamycin 89.2 µM -0.321440490150304 0.367078779248617 no 2161 0.373938301545371 3025 5288382 HSP90 inhibitor.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.323221958856187 0.366427639640785 no 2162 0.37326357596684 3038 75037 A free radical scavenger.
SGTC_489 paxilline 115 µM -0.323643258327904 0.366273707779821 no 2163 0.373104066854848 3039 105008 A toxic potassium channel blocker.
SGTC_393 acivicin 6.25 µM -0.324750769853099 0.365869154574452 no 2164 0.372684853295838 2957 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_136 0097-0015 404.482 µM -0.326585699159023 0.36519921762492 no 2165 0.371990630683406 3032 4861337
SGTC_3303 9125618 40.5795 µM -0.328023524605591 0.364674551423101 no 2166 0.371446937884169 3062 22695467
SGTC_2799 7812892 81.82 µM -0.329022440338476 0.364310193593146 no 2167 0.37106936327916 3140 20205235
SGTC_2352 9027995 87.8 µM -0.332548188630088 0.36302514710505 no 2168 0.369737679370135 3039 2997347
SGTC_320 4092-0846 5.34 µM -0.333020439511855 0.362853140233835 no 2169 0.369559427218122 3072 1359356
SGTC_2019 4016004 108 µM -0.33305059858312 0.362842156402982 no 2170 0.369548044561052 3066 45595336
SGTC_2345 9052315 157.45 µM -0.33396940661296 0.362507583778354 no 2171 0.369201322256365 3079 6469265
SGTC_756 0508-1999 28.3 µM -0.334020769390913 0.362488883751307 no 2172 0.369181943084908 2993 6753853
SGTC_2740 felodipine 17.08 µM -0.3353469167423 0.362006177161919 no 2173 0.368681703049711 3081 3333 L-type calcium channel blocker
SGTC_2184 6075246 200 µM -0.336013588962644 0.361763596853506 no 2174 0.3684303095761 3050 2267320
SGTC_1867 st057372 64 µM -0.336145681293465 0.361715539345475 no 2175 0.368380505946766 3003 688837
SGTC_1307 1187-1599 12.2 µM -0.337262684247898 0.361309241334392 no 2176 0.367959443559329 2984 1538471
SGTC_1555 citronellol 128 µM -0.338352254947327 0.360913072169401 no 2177 0.367548874755926 3090 8842 A terpine precursor.
SGTC_1252 0493-0875 34.8 µM -0.338829824091135 0.360739474474741 no 2178 0.367368966242024 2980 3960963
SGTC_1590 st077108 57.8 µM -0.340271811428679 0.360215482352785 no 2179 0.366825921590427 3108 5489485
SGTC_3194 9111903 49.47 µM -0.340940549462329 0.359972564076435 no 2180 0.366574168811573 3210 17087251
SGTC_1815 st051655 58.2 µM -0.341342838202528 0.359826460411961 no 2181 0.366422751038866 3109 5984156
SGTC_2241 6772625 37.8075 µM -0.343077852703705 0.359196570827478 no 2182 0.365769946049815 2993 2285411
SGTC_1713 st033146 12.748 µM -0.34498425595956 0.358504900386325 no 2183 0.365053103454794 3165 674619
SGTC_2390 9097792 176.6 µM -0.345355867289824 0.358370128423841 no 2184 0.364913425594553 3013 4497149
SGTC_427 1354-0053 47.3 µM -0.346961256113515 0.357788106344354 no 2185 0.364310212960615 3215 6813657
SGTC_3321 9137793 26.8275 µM -0.348581851693345 0.357200906328688 no 2186 0.363701627196322 3082 4904192
SGTC_71 0417-1750 47.813 µM -0.348768719388946 0.357133219157495 no 2187 0.363631474440222 3206 6811472
SGTC_3043 9092303 49.47 µM -0.349041583437347 0.357034390484436 no 2188 0.363529045658802 3071 25236084
SGTC_1540 guanosine 70.6 µM -0.349596785490967 0.356833331385701 no 2189 0.363320661849313 3022 6802 Guanosine is a purine nucleoside
SGTC_577 r071-0003 38.6 µM -0.350760691165843 0.356411967414252 no 2190 0.362883944829878 3019 4568517 YMR134W ERG29
SGTC_2466 5983409 37.09 µM -0.351884337222194 0.356005344688695 no 2191 0.36246250300419 3053 2879657
SGTC_1619 st003326 88.7 µM -0.353240708105853 0.355514722114343 no 2192 0.361953995904407 3167 2849032
SGTC_672 1441-0018 53.7 µM -0.353796832169888 0.355313631646188 no 2193 0.361745573856327 3008 251141
SGTC_2803 7707263 71.43 µM -0.353859439818315 0.355290995691603 no 2194 0.361722112568373 3024 2199229
SGTC_485 niflumic acid 177 µM -0.357385864349616 0.354016834339056 no 2195 0.360401478790902 3144 4488 A COX2 inhibitor.
SGTC_2561 acetosyringone 100 µM -0.357637220527894 0.353926076958743 no 2196 0.360307410108132 2992 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1520 flindersine 88 µM -0.359045122951095 0.353417878047055 no 2197 0.359780666757226 3287 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1427 4048-4900 550 nM -0.359049744372489 0.353416210320383 no 2198 0.359778938166865 3156 24132586
SGTC_3347 9188721 44.724 µM -0.360715184616471 0.352815388421545 no 2199 0.35915618611416 3105 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_144 4161-2749 112.381 µM -0.360828436674216 0.352774545073105 no 2200 0.359113851745637 3065 797501 YMR168C CEP3
SGTC_1133 3473-0247 50 µM -0.361710753510557 0.352456403480661 no 2201 0.358784095149515 3072 711311
SGTC_799 1310-0557 151 µM -0.363475119361532 0.351820526546906 no 2202 0.358124997864422 3203 5354492
SGTC_3254 9136651 49.47 µM -0.363590522990542 0.351778949528276 no 2203 0.358081902337367 3077 16454030
SGTC_189 3970-0742 2.116 µM -0.364448587187586 0.351469866243683 no 2204 0.357761529562148 3101 2891807
SGTC_271 rotenone 740 µM -0.366357123008699 0.350782744905951 no 2205 0.357049304932104 3163 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_397 arbidol 50 µM -0.368652830678932 0.349956878222506 no 2206 0.356193255817933 3203 131410 A RNA synthesis inhibitor.
SGTC_2895 9054447 58.44 µM -0.370956119164674 0.34912899707715 no 2207 0.355335107663874 3057 2697450
SGTC_1057 3448-5381 134 µM -0.370997163740467 0.349114250739466 no 2208 0.355319822107983 3175 5497911
SGTC_2288 7946289 167.31 µM -0.371130659854103 0.34906629034368 no 2209 0.355270107957084 3243 1246052
SGTC_576 1073-0113 22.7 µM -0.374583318564397 0.347826712559174 no 2210 0.353985190543289 3179 5439563
SGTC_2584 androsterone 48.74 µM -0.377655196465434 0.346725208358178 no 2211 0.352843377543265 3184 2754130 A steroid.
SGTC_1177 0983-0204 23.6 µM -0.379036371863321 0.346230372132013 no 2212 0.352330427332348 3213 766818
SGTC_2526 patulin 37.61 µM -0.3795099552826 0.346060760904928 no 2213 0.35215460650229 3217 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2778 tioconazole 65.09 nM -0.380421109536289 0.345734523031964 no 2214 0.351816423647165 3078 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2627 acetyl isogambogic acid 100 µM -0.380553356325685 0.34568718171198 no 2215 0.351767348831075 3160 6857789 A caspase activator and apoptosis inducer.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.383128551189803 0.344765802743752 no 2216 0.350812225514544 3233 1273210
SGTC_2882 9058044 58.44 µM -0.383474882403865 0.344641958961642 no 2217 0.350683845215823 3158 18076804
SGTC_2982 9019404 25.97 µM -0.384659370374448 0.344218526541403 no 2218 0.350244900485537 3073 22333232
SGTC_2312 7706453 155.7 µM -0.385170886760375 0.344035729270398 no 2219 0.350055405748862 3103 976098
SGTC_1986 st071812 45 µM -0.386660399935423 0.343503639372011 no 2220 0.349503818205115 3164 11838594
SGTC_1912 st060209 90.8 µM -0.386792901375677 0.343456321671774 no 2221 0.349454766437114 3139 688787
SGTC_2060 5238662 140 µM -0.386889825486061 0.343421710575186 no 2222 0.349418886917395 3163 790130
SGTC_2473 5854593 8.94 µM -0.388195860644817 0.342955460349369 no 2223 0.348935548092172 3017 2872951
SGTC_3183 9108214 49.47 µM -0.388935065487012 0.342691672556998 no 2224 0.348662090936159 3162 4974831
SGTC_1216 1165-0504 9.65 µM -0.390579438687321 0.342105147513712 no 2225 0.348054063156708 3216 6304004
SGTC_2995 9067767 71.4286 µM -0.393721507243093 0.340985475193542 no 2226 0.34689333041368 3151 11673567
SGTC_622 1348-1566 26.3 µM -0.395771135968476 0.340255845749152 no 2227 0.346136936011627 3169 7340407
SGTC_2616 abietic acid 100 µM -0.395923764777145 0.3402015366291 no 2228 0.346080634423079 3265 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3261 9137475 49.47 µM -0.397888086868653 0.339502878257319 no 2229 0.345356340958877 3131 17027690
SGTC_3242 9133940 49.47 µM -0.398433661299969 0.33930892930376 no 2230 0.345155274668302 3229 17248444
SGTC_1488 4013-0813 75.9 µM -0.403218033163453 0.337609937444893 no 2231 0.343393917323145 3125 2910057
SGTC_2221 6807166 181.081 µM -0.403461249332926 0.337523656239108 no 2232 0.343304468141083 3167 674925
SGTC_1178 0988-0033 191 µM -0.40406753267262 0.337308613741743 no 2233 0.343081529619316 3223 5392207
SGTC_1747 st037496 66.6 µM -0.404839169460015 0.337034998922417 no 2234 0.34279786740442 3108 723305
SGTC_1511 0906-3109 28.5 µM -0.405560870139042 0.336779168961411 no 2235 0.34253264243645 3120 2882180
SGTC_2198 6589944 200 µM -0.406547205505743 0.336429652871583 no 2236 0.34217028978337 3169 5290268
SGTC_1294 1000-1494 117 µM -0.406904480938714 0.336303084213155 no 2237 0.342039072380463 3142 712797 YDL207W GLE1
SGTC_2502 avocadyne acetate 18.59 µM -0.407402133998761 0.336126816191304 no 2238 0.341856329942623 3047 3952079
SGTC_642 0335-0876 158 µM -0.407417871792155 0.336121242474243 no 2239 0.34185055149509 3152 6812350
SGTC_277 nystatin 15.5 µM -0.4097441958222 0.335297745438226 no 2240 0.340996802973195 3074 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2401 5128683 200 µM -0.411763672198676 0.334583510619575 no 2241 0.340256325312334 3118 708373
SGTC_227 fluconazole 33.516 µM -0.411952950965814 0.33451659840024 no 2242 0.340186954325849 3175 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1304 1165-0502 251 µM -0.412823937253058 0.334208762507835 no 2243 0.339867806129847 3140 767425
SGTC_933 2914-0560 114 µM -0.413000158004811 0.334146493711099 no 2244 0.339803248987038 3280 463887
SGTC_1428 4049-0204 61.7 µM -0.413071362223699 0.334121334512619 no 2245 0.339777165191322 3242 X1428
SGTC_2056 5235370 200 µM -0.416172292544475 0.333026380555762 no 2246 0.338641966521519 3124 5511916
SGTC_2716 st080858 38.6235 µM -0.419880662749286 0.331718803990872 no 2247 0.337286317383691 3267 5296050
SGTC_159 3970-0959 50 µM -0.420153016745258 0.331622852111967 no 2248 0.337186837339084 3310 6615653
SGTC_2589 lobaric acid 100 µM -0.421945400755334 0.330991660747126 no 2249 0.336532435235055 3129 73157 A novel microtubule depolymerizer.
SGTC_1446 4239-0190 62 µM -0.42465564400226 0.330038155682873 no 2250 0.335543861514225 3142 1340085
SGTC_2587 piperic acid 92.2 µM -0.425285975122876 0.329816553417698 no 2251 0.335314108098484 3168 5370536
SGTC_2447 5741742 33.78 µM -0.426147949022333 0.329513610377364 no 2252 0.335000021428556 3242 1776504
SGTC_2679 rapamycin 1 nM -0.426319120063639 0.329453465160636 no 2253 0.334937663722939 3222 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_547 1120-0019 610 nM -0.428269943852909 0.328768306541773 no 2254 0.334227299344797 3152 3676939
SGTC_342 k048-0088 23.3 µM -0.4296878810662 0.328270666457072 no 2255 0.333711350113064 3134 6820570
SGTC_599 1935-0052 86.5 µM -0.43127712138475 0.327713267730008 no 2256 0.333133441826053 3143 9557311
SGTC_456 gingerol 170 µM -0.431708114465258 0.327562170398893 no 2257 0.332976784535564 3342 442793 A herb.
SGTC_869 0564-0080 44.1 µM -0.434127028488592 0.326714673333269 no 2258 0.332098099576947 3195 6843321
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.434728136155272 0.326504206085271 no 2259 0.331879886531814 3254 17037758
SGTC_589 1227-0070 34.1 µM -0.436103725421541 0.326022775608424 no 2260 0.331380737175564 3285 2841384
SGTC_1950 st077106 7.18 µM -0.436231772369746 0.325977976309831 no 2261 0.331334288995072 3225 13831864
SGTC_819 1013-0258 27.7 µM -0.437223257707368 0.325631174176779 no 2262 0.33097472213801 3180 5753198
SGTC_2127 5253358 187.912 µM -0.439631661885851 0.324789390421719 no 2263 0.330101952546838 3110 20612
SGTC_2290 7904846 200 µM -0.441044824097895 0.324295878804626 no 2264 0.32959027343624 3228 2962154
SGTC_1081 sertraline 6 µM -0.442877293968998 0.323656393901184 no 2265 0.328927245876494 3284 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3288 9119690 36.221 µM -0.445320068045168 0.322804737840248 no 2266 0.328044233658947 3204 17595618 YKL019W RAM2
SGTC_1456 k015-0012 13 µM -0.445775459006431 0.322646071522998 no 2267 0.327879725303714 3364 2989616
SGTC_595 3909-8003 73.7 µM -0.445827124148758 0.322628072506609 no 2268 0.327861063564522 3299 699517
SGTC_549 1661-1316 519 µM -0.445838887603538 0.322623974431877 no 2269 0.32785681459875 3336 2857282
SGTC_2634 4'-methoxyflavone 100 µM -0.446608934782577 0.322355757368587 no 2270 0.327578721667752 3232 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1117 retinoic acid 1.10837 µM -0.447024309230322 0.322211115629794 no 2271 0.327428754061668 3335 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3182 9108849 49.47 µM -0.448255985663657 0.321782379437542 no 2272 0.326984230953818 3292 17133045
SGTC_908 3448-7491 47.7 µM -0.451659911917867 0.320598736253322 no 2273 0.32575700101184 3181 1203031
SGTC_1862 st057513 3.81 µM -0.452014106083497 0.320475677197991 no 2274 0.325629410198247 3160 5393163
SGTC_1091 telmisartan 47.6 µM -0.452508975945771 0.320303775687739 no 2275 0.325451178205552 3312 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1985 st071382 65.5 µM -0.455743085876182 0.31918130296666 no 2276 0.324287367574993 3232 6123237
SGTC_685 1278-0033 54.9 µM -0.45595064783873 0.319109320214658 no 2277 0.324212733797052 3329 3590572
SGTC_486 niguldipine 82 µM -0.456370560698673 0.318963714759656 no 2278 0.324061765867685 3196 1236 A calcium channel blocker.
SGTC_766 1391-0721 126 µM -0.457002750177486 0.318744554735597 no 2279 0.323834534381581 3325 1020919 YIL115C NUP159
SGTC_146 3448-8650 53.125 µM -0.458366261731845 0.31827208439645 no 2280 0.323344663167401 3218 2891488 YIL048W NEO1
SGTC_2117 5521686 200 µM -0.458405408308853 0.318258524077421 no 2281 0.323330603423581 3183 803312
SGTC_1689 st020265 53.493 µM -0.458589215714842 0.318194856708111 no 2282 0.323264591190407 3332 5758320 YPR016C TIF6
SGTC_2765 myclobutanil 7.74 µM -0.458595017336578 0.318192847224754 no 2283 0.323262507697869 3306 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3055 9094636 49.47 µM -0.458775903156674 0.318130197247347 no 2284 0.32319755032232 3385 25236176
SGTC_2433 5607874 27.82 µM -0.46031383893386 0.317597742047751 no 2285 0.322645484635731 3197 2252428
SGTC_1954 st077032 68.9 µM -0.461252603942923 0.317272913533624 no 2286 0.32230869246347 3267 698907
SGTC_722 3534-0461 190 µM -0.461365419175496 0.317233887027607 no 2287 0.322268228579 3255 658262
SGTC_1996 st072960 66.8 µM -0.461864125968867 0.317061392269439 no 2288 0.322089380684334 3335 1719405
SGTC_41 0478-0632 82.643 µM -0.462096044529965 0.316981188860019 no 2289 0.322006223305267 3340 3750424
SGTC_2520 obtusaquinone 4.71 µM -0.462558141057166 0.316821409620635 no 2290 0.321840559230502 3373 5967872
SGTC_1040 k898-0338 155 µM -0.463865573949245 0.316369523339701 no 2291 0.321372029448902 3377 20969351
SGTC_1666 st014829 29 µM -0.466234270184041 0.31555153235859 no 2292 0.320523910802318 3233 3858230
SGTC_1008 4106-0037 6 µM -0.466444903272127 0.315478837283036 no 2293 0.320448538274125 3173 2905394
SGTC_1562 morin hydrate 59.1 µM -0.466899260720486 0.315322050773075 no 2294 0.320285977120097 3367 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1529 apigenin 74 µM -0.467083857735968 0.315258360815626 no 2295 0.320219941383311 3422 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.468065775903462 0.314919670148369 no 2296 0.31986877634656 3331 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2756 carbadox 75.1 µM -0.468067033578027 0.314919236441422 no 2297 0.319868326665715 3228 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2941 9056145 11.23 µM -0.46914087119956 0.31454901854734 no 2298 0.319484473280455 3287 2119517
SGTC_635 k038-0028 24.7 µM -0.471387123902858 0.313775200089536 no 2299 0.318682154644281 3242 4035102
SGTC_468 gf-109203x 121 µM -0.471531372047483 0.31372553553801 no 2300 0.318630660937697 3255 2396 A protein kinase C inhibitor.
SGTC_1186 1319-0216 26 µM -0.475543801621859 0.312345413836778 no 2301 0.317199710364299 3387 4565136
SGTC_1484 3473-2379 286 µM -0.478189484002859 0.311436837206225 no 2302 0.316257673277565 3391 671917
SGTC_1697 st025554 27.742 µM -0.480022844171357 0.310807899681313 no 2303 0.315605574714748 3231 1269519
SGTC_655 k060-0012 42 µM -0.480127808569253 0.31077190815523 no 2304 0.315568257806359 3231 5994525
SGTC_1273 0849-0096 14.1 µM -0.481503355473348 0.310300410602074 no 2305 0.315079397745856 3288 5286025
SGTC_184 1494-0393 24.714 µM -0.482369555080634 0.310003662358879 no 2306 0.314771722310903 3194 3090647
SGTC_313 3474-0040 5.03 µM -0.483183950442395 0.309724774380711 no 2307 0.314482565048812 3211 1043375 YIL048W NEO1
SGTC_304 1310-0298 97 µM -0.486773544189389 0.308496832180878 no 2308 0.313209410271067 3319 1550234
SGTC_956 1185-0240 191 µM -0.487946925449578 0.308095900542641 no 2309 0.312793717585912 3243 1416193
SGTC_2322 7413319 38.22 µM -0.487969429832673 0.308088213274917 no 2310 0.312785747303156 3354 1840400
SGTC_1737 st035557 69.7 µM -0.488093838550299 0.308045718045214 no 2311 0.312741687570063 3270 5716916
SGTC_2308 7584454 197.62 µM -0.48991925151186 0.307422494028982 no 2312 0.312095519796577 3440 893577
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.491009855421495 0.307050410099886 no 2313 0.311709738524045 3345 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3045 9092950 49.47 µM -0.49286131246903 0.306419199016983 no 2314 0.311055292409985 3411 44120432
SGTC_1270 0831-1170 17.3 µM -0.493320076909179 0.306262882642958 no 2315 0.310893222283744 3371 6764716
SGTC_849 0386-0493 241 µM -0.494733876820333 0.3057813756271 no 2316 0.310393992535159 3264 726119
SGTC_3212 9128307 49.47 µM -0.495434922942977 0.305542740191053 no 2317 0.310146574130328 3141 27243542
SGTC_503 tyrphostin 8 294 µM -0.496066237796027 0.305327911878324 no 2318 0.309923839325421 3346 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_495 decylubiquinone 155 µM -0.498690964432114 0.304435470529873 no 2319 0.308998555484674 3323 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_767 0929-0023 86 µM -0.500828799654381 0.303709437752966 no 2320 0.308245807589088 3402 1204563
SGTC_1942 st076330 65.2 µM -0.504213110515002 0.302561670843675 no 2321 0.307055814196884 3423 24208414
SGTC_2643 anethole 100 µM -0.504608569599051 0.302427680432802 no 2322 0.306916894833914 3349 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3027 9089541 49.47 µM -0.505347087798221 0.302177525172054 no 2323 0.306657537730111 3374 9943819
SGTC_1645 Cervolide 78 µM -0.50593242477981 0.301979322364163 no 2324 0.306452044437736 3346 23173 A fragrance.
SGTC_2476 5806916 10.51 µM -0.506225755467447 0.301880018701182 no 2325 0.306349088198029 3259 2870194
SGTC_779 1360-0071 233 µM -0.506762581117763 0.301698320686476 no 2326 0.306160707170322 3446 7566
SGTC_797 k781-0471 270 µM -0.511956908679967 0.29994275593611 no 2327 0.304340584070351 3287 23738129
SGTC_524 r073-0010 27.8 µM -0.512031492885183 0.299917581867122 no 2328 0.304314484438881 3275 2772106
SGTC_518 1021-0119 62.6 µM -0.512460244455795 0.299772885844464 no 2329 0.304164468550974 3272 1097762
SGTC_2007 4011539 71.82 µM -0.512641636068059 0.299711678922136 no 2330 0.304101011359388 3318 45595301
SGTC_2867 9039098 71.43 µM -0.512752893577303 0.299674140132022 no 2331 0.304062092473106 3328 6463460
SGTC_1123 mangostin 811.285 nM -0.514132688748632 0.299208768075568 no 2332 0.303579612217439 3328 5281650 An antioxidant.
SGTC_2041 5107442 45.335 µM -0.517059204093383 0.298222811205256 no 2333 0.302557415426541 3443 793005
SGTC_749 1000-0129 128 µM -0.517203988005141 0.298174071252699 no 2334 0.302506884210261 3445 708470
SGTC_1579 chlormadinone acetate 49.4 µM -0.51862186438014 0.297696950238145 no 2335 0.302012229469112 3421 45114258 A steroidal progestin.
SGTC_2704 st078022 71.1 µM -0.518938861792883 0.297590327018202 no 2336 0.301901688242452 3431 54697681
SGTC_235 0330-0087 5 mM -0.519958801113175 0.297247385085679 no 2337 0.301546145204349 3366 46494818 YHR062C RPP1
SGTC_592 k241-0073 46.5 µM -0.520644115525786 0.297017058121733 no 2338 0.301307355712104 3418 4230158
SGTC_2611 pyromycin 23.93 µM -0.520834149600686 0.296953204127891 no 2339 0.301241155726779 3303 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1194 1488-0194 225 µM -0.521904015895643 0.296593831992177 no 2340 0.300868581034647 3297 1391452
SGTC_1868 st057644 42.7 µM -0.52195199132841 0.296577721531033 no 2341 0.300851878740088 3300 688665
SGTC_2709 st078560 56 µM -0.522040079049685 0.296548142147369 no 2342 0.300821212735861 3462 17250903
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.522801186964451 0.296292622509633 no 2343 0.300556306762721 3348 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_605 1315-0399 119 µM -0.522948272427225 0.296243254527098 no 2344 0.300505125358262 3436 24020461
SGTC_3008 9078912 71.4286 µM -0.527122493803631 0.294843788385719 no 2345 0.299054263581919 3346 16648731
SGTC_611 3453-1652 23.7 µM -0.528582681332991 0.294354960548269 no 2346 0.298547488450805 3431 1560575
SGTC_1856 st057054 55.7 µM -0.530076361391671 0.293855307943712 no 2347 0.298029493900928 3500 1266018
SGTC_1193 1488-0126 41.5 µM -0.530301142198074 0.293780150237002 no 2348 0.29795157744751 3375 1384710
SGTC_3103 9120822 49.47 µM -0.532204224958718 0.293144192232975 no 2349 0.297292278541042 3509 17141819
SGTC_1073 triclabendazole 3.09 µM -0.532636226652915 0.292999918084825 no 2350 0.297142709915267 3423 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2682 pyrogallin 40.03 µM -0.532736757899357 0.2929663487295 no 2351 0.297107908689616 3371 822798 An ATP competetive kinase inhibitor.
SGTC_164 4100-3994 89.624 µM -0.533142905104649 0.292830746382812 no 2352 0.296967330379852 3477 4615967
SGTC_1170 0310-0127 64.8 µM -0.535322568716608 0.292103509751415 no 2353 0.296213411440921 3360 774975
SGTC_1567 st069303 68.4 µM -0.535828927204618 0.291934685527705 no 2354 0.296038393994806 3414 5581319
SGTC_24 0417-1663 219 µM -0.536736101221341 0.291632339681292 no 2355 0.295724957658262 3414 4329390
SGTC_1655 st012546 55.1 µM -0.53715303811634 0.291493430604278 no 2356 0.295580953582137 3395 720985 YLR208W SEC13
SGTC_3277 9138724 49.47 µM -0.537725597330375 0.291302723809839 no 2357 0.295383252321302 3324 15943418
SGTC_2130 NSC 7 2.4545 µM -0.538086610538891 0.291182508246445 no 2358 0.29525862790795 3422 21448
SGTC_739 1486-1183 203 µM -0.538977340474351 0.290885998831728 no 2359 0.294951244953826 3444 4346692
SGTC_2382 9035899 200 µM -0.539681296044577 0.290651763429692 no 2360 0.2947084205318 3359 6462679
SGTC_15 0266-0086 27.098 µM -0.540453438563083 0.290394940893606 no 2361 0.29444218158254 3470 1712902 YIL048W NEO1
SGTC_2103 5378138 10 µM -0.540942960503916 0.290232175916122 no 2362 0.294273449276332 3475 244142
SGTC_1285 0929-0069 65.5 µM -0.541031666732483 0.290202685863045 no 2363 0.294242878090151 3370 1206237
SGTC_2003 4023581 200 µM -0.541597125217559 0.290014734314333 no 2364 0.29404803633836 3433 16641307
SGTC_284 0988-0104 32.6 µM -0.542882124128146 0.289587828575288 no 2365 0.293605482262428 3405 4666532
SGTC_1493 4348-0038 111 µM -0.544392107162827 0.289086555385399 no 2366 0.293085838015173 3450 800424
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.547232165735578 0.288144840579579 no 2367 0.292109620191173 3348 6708630 An antioxidant.
SGTC_2828 7998861 71.43 µM -0.547339789767415 0.288109182774756 no 2368 0.292072656191294 3404 2988188
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.548503553306819 0.287723739742202 no 2369 0.291673095044801 3444 165521
SGTC_262 fenpropimorph 62.5 µM -0.549572757078152 0.287369830174085 no 2370 0.291306224334823 3401 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.550260586505282 0.287142265533761 no 2371 0.291070326652486 3406 688669
SGTC_2475 5812728 15.03 µM -0.550703651623803 0.286995725031249 no 2372 0.290918420496852 3428 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1377 2944-0135 198 µM -0.551025056925958 0.286889444784397 no 2373 0.290808248952448 3421 1894137
SGTC_2620 irigenin 100 µM -0.551924628522308 0.286592079395908 no 2374 0.290499996888353 3482 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_283 0987-0079 11.7 µM -0.552207763552197 0.286498515593166 no 2375 0.290403007958832 3472 411556
SGTC_1783 st039459 87.517 µM -0.552387546598044 0.286439112646291 no 2376 0.290341430496089 3509 729761
SGTC_1633 st005664 67.9 µM -0.552750949815172 0.286319056761593 no 2377 0.29021697999133 3377 2063822
SGTC_1676 st018489 23.4 µM -0.553119877797311 0.286197200127264 no 2378 0.290090663053084 3387 3696235
SGTC_3315 9136395 68.55 µM -0.554612124897133 0.285704563510351 no 2379 0.289579996922274 3519 16876844
SGTC_2096 5468907 200 µM -0.555094680443092 0.285545343462447 no 2380 0.289414950571842 3433 759785
SGTC_1407 3909-7909 12.3 µM -0.555140369613748 0.28553027042957 no 2381 0.289399325996184 3454 4411780
SGTC_3251 9135047 49.47 µM -0.556100788716913 0.285213512170932 no 2382 0.289070977976594 3432 17682963
SGTC_2523 spermine 47.74 µM -0.556312921629963 0.28514357066119 no 2383 0.288998477621536 3425 1103 A DNA binding polyamine.
SGTC_2083 5306046 65.942 µM -0.556720277163383 0.285009285994112 no 2384 0.288859280307787 3419 539837
SGTC_2128 5255449 168.493 µM -0.557293174079776 0.284820481687908 no 2385 0.28866356932172 3410 736008
SGTC_2188 6126565 140.678 µM -0.558647354846898 0.284374434338581 no 2386 0.288201207403709 3441 874518
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.558924969748008 0.28428303329534 no 2387 0.28810646370072 3478 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2839 9003951 25.97 µM -0.558995995629143 0.284259651217239 no 2388 0.288082226531096 3451 2990634
SGTC_1641 st009299 47.1 µM -0.559163407649463 0.284204541973854 no 2389 0.288025101958284 3434 4046054
SGTC_1924 st058459 75.1 µM -0.559793347351649 0.283997222123562 no 2390 0.287810200942163 3429 688683
SGTC_1664 st014217 9.02 µM -0.563295639923855 0.282845901859092 no 2391 0.286616793296871 3519 3982782
SGTC_2187 6125751 200 µM -0.564018988354997 0.28260839273679 no 2392 0.286370604748727 3440 874498
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.564359427887467 0.282496643701322 no 2393 0.286254772355819 3443 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1957 st077035 62.4 µM -0.565545550820175 0.282107465751308 no 2394 0.285851375433286 3519 705593
SGTC_1997 st073024 93.8 µM -0.565625784786486 0.282081149565855 no 2395 0.285824097860958 3473 686268
SGTC_1630 st005209 31.3 µM -0.5656302534619 0.282079683906009 no 2396 0.285822578657776 3494 3367314
SGTC_590 k048-0076 22.4 µM -0.56621873508321 0.281886702629783 no 2397 0.285622547751323 3470 6832814
SGTC_3300 9124615 50.48 µM -0.571263789163186 0.280234889342806 no 2398 0.283910421857782 3535 24824903
SGTC_1035 k081-0041 55.2 µM -0.573246148989256 0.279587125793022 no 2399 0.283239020754883 3520 731709
SGTC_1932 st074806 40.9 µM -0.573323520863783 0.27956185820653 no 2400 0.283212831294562 3587 17251235
SGTC_104 0074-0074 590.992 µM -0.573650680185456 0.279455028971811 no 2401 0.283102104593676 3379 3943124
SGTC_1061 3448-9325 110 µM -0.573761629292886 0.27941880461734 no 2402 0.283064558712054 3485 723482
SGTC_2027 5150920 200 µM -0.574126415088248 0.279299719874142 no 2403 0.282941129734259 3423 786715
SGTC_3093 9117344 49.47 µM -0.57430979491505 0.279239864634481 no 2404 0.282879091069988 3483 24824913
SGTC_2311 7694451 200 µM -0.575185958880232 0.27895397048898 no 2405 0.282582768942046 3393 2163142
SGTC_419 nsc-638432 893 µM -0.576865077472445 0.278406468800965 no 2406 0.282015301727063 3423 368090
SGTC_2277 7947813 106.88 µM -0.580712738901629 0.277153859673753 no 2407 0.280717037322281 3561 1246798
SGTC_729 4092-0585 94.1 µM -0.580795500970544 0.277126946741954 no 2408 0.280689143823467 3413 2169061
SGTC_2773 thioridazine 9.09 µM -0.582275164907729 0.276645999072331 no 2409 0.280190675518687 3512 5452 An antipsychotic.
SGTC_1089 terbinafine 2.25 µM -0.582952160320957 0.276426086009189 no 2410 0.279962752801453 3499 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_699 0375-0592 111 µM -0.583246266377524 0.276330576241474 no 2411 0.279863764709755 3527 762578
SGTC_3301 9125354 19.7965 µM -0.584199998591126 0.276020966927539 no 2412 0.279542881242255 3480 41905162
SGTC_973 1325-0077 65.9 µM -0.584248006945873 0.276005386518642 no 2413 0.279526733541409 3489 2835149
SGTC_2369 9071472 200 µM -0.584786534314586 0.275830644943026 no 2414 0.279345629884347 3493 17296037
SGTC_2276 7947513 42.08 µM -0.585194291325842 0.275698371956731 no 2415 0.279208541479711 3417 2105100
SGTC_1084 voriconazole 435 nM -0.586386170741769 0.275311915041782 no 2416 0.278808017751228 3502 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2181 6316240 54.2555 µM -0.586499952167762 0.275275036313085 no 2417 0.278769796830589 3478 12779990
SGTC_1361 1608-0041 5.61 µM -0.587156921915875 0.275062147461613 no 2418 0.278549160536066 3480 X1361
SGTC_1330 1469-0054 61.8 µM -0.587247375715224 0.275032842562799 no 2419 0.278518789253768 3500 7102664
SGTC_2912 7964298 10.93 µM -0.587830085199459 0.274844095300451 no 2420 0.278323174080407 3498 2975850
SGTC_2638 epoxomicin 18 µM -0.588780297247424 0.274536446133881 no 2421 0.278004332262472 3473 9915668 A protesome inhibitor.
SGTC_3269 9137823 49.47 µM -0.589079976380967 0.274439454586476 no 2422 0.277903812489037 3391 17682936
SGTC_2696 st077691 74.316 µM -0.590778420755492 0.273890070560709 no 2423 0.277334447778659 3497 757133
SGTC_2717 st081029 62.2815 µM -0.591719822881551 0.273585796119946 no 2424 0.277019110097564 3500 5292846
SGTC_782 0083-0095 30.5 µM -0.592275862379226 0.273406154927359 no 2425 0.276832938267221 3515 3591729 An indicator and reagent.
SGTC_2761 levamisole 97.89 µM -0.592419015984159 0.273359915358396 no 2426 0.276785017836792 3551 26879 An alkaline phosphatase inhibitor.
SGTC_2097 5376186 200 µM -0.593126920451115 0.27313131443634 no 2427 0.27654810774533 3493 742755
SGTC_1447 4239-0816 81.9 µM -0.593231375713036 0.273097591114768 no 2428 0.276513158754982 3438 1341554
SGTC_1704 st028805 70.8 µM -0.59358460566618 0.272983566317255 no 2429 0.276394989943027 3486 2876101
SGTC_1150 3909-7983 10.9 µM -0.593909901672359 0.27287857965113 no 2430 0.276286188008007 3432 23965914
SGTC_1489 4065-0444 182 µM -0.593954309720341 0.272864248864921 no 2431 0.276271336453988 3493 2877968
SGTC_3289 9119912 71.43 µM -0.595357235176356 0.272411707316986 no 2432 0.275802352470848 3539 17014829
SGTC_482 fipronil 114 µM -0.597958066696317 0.271573744649288 no 2433 0.274933956674484 3535 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3026 9090633 49.47 µM -0.598169726795484 0.271505606344265 no 2434 0.274863344474386 3471 25236842
SGTC_1357 1503-1303 39.5 µM -0.599925626948619 0.270940669824052 no 2435 0.274277901233526 3517 292895
SGTC_269 exalamide 29 µM -0.601278995916375 0.270505642743548 no 2436 0.273827088447742 3469 3316 A derivative of salicylamide.
SGTC_2415 st077333 57.7 µM -0.602818070141199 0.270011347013251 no 2437 0.273314862133316 3597 2766255
SGTC_3298 9116858 71.43 µM -0.603211969756846 0.269884913188735 no 2438 0.273183842917278 3537 2506942
SGTC_1335 1486-0900 202 µM -0.603896711822469 0.269665195371858 no 2439 0.27295615753948 3542 X1335
SGTC_294 k038-0071 157 µM -0.60400980879681 0.269628913804883 no 2440 0.272918560424175 3514 24152826
SGTC_1712 st032288 53.4 µM -0.604059967483711 0.269612823655422 no 2441 0.272901886866173 3543 2883011
SGTC_740 k014-0057 261 µM -0.604491152937476 0.269474525717563 no 2442 0.27275857469441 3488 4012779
SGTC_1012 4112-3522 18 µM -0.604773493448595 0.269383987407378 no 2443 0.272664754026651 3530 3112398
SGTC_2847 9005661 71.43 µM -0.604868479003004 0.269353531758416 no 2444 0.272633194292415 3447 2991449
SGTC_1556 plumbagin 1.48 µM -0.60493585270098 0.269331930470818 no 2445 0.272610809924472 3493 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2474 5321570 43.32 µM -0.606232204158186 0.268916464799279 no 2446 0.272180285334856 3496 2841384
SGTC_2376 9072922 81.32 µM -0.607172588401381 0.268615284014586 no 2447 0.271868190810133 3560 17087968
SGTC_3204 9114183 49.47 µM -0.607453143168796 0.268525462411173 no 2448 0.271775114847579 3525 17027248
SGTC_2490 carminic acid 95.39 µM -0.607672019776029 0.268455397995041 no 2449 0.271702512050085 3503 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2208 7283366 200 µM -0.608507187414381 0.268188137627143 no 2450 0.271425570233782 3541 898663
SGTC_3007 9078383 71.4286 µM -0.610072926231673 0.267687449658073 no 2451 0.270906750081769 3501 6496995
SGTC_1422 4031-0024 15.5 µM -0.610713207718518 0.267482837872247 no 2452 0.270694730314782 3498 782427
SGTC_152 4469-0003 551.229 µM -0.610874279591068 0.267431377299685 no 2453 0.2706414067875 3549 697280
SGTC_2421 5690543 90.72 µM -0.614415795654329 0.266301167876364 no 2454 0.269470300237353 3549 3397993
SGTC_2568 diosmetin 100 µM -0.615301108051247 0.266019014932081 no 2455 0.269177942973083 3552 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2059 5238311 157 µM -0.615650636366438 0.265907660433591 no 2456 0.269062561849871 3506 703021
SGTC_679 0422-0091 41.4 µM -0.616671926629613 0.265582428001582 no 2457 0.268725570875333 3560 627384 YHR062C RPP1
SGTC_997 3996-0078 137 µM -0.618378386807428 0.265039452072673 no 2458 0.268162970724236 3532 735687
SGTC_2411 st077133 39.94 µM -0.618603941482001 0.264967725399945 no 2459 0.268088652336979 3649 1403142 YNL221C POP1
SGTC_3311 9131146 2.8755 µM -0.622643345182705 0.263684862161502 no 2460 0.266759460285292 3507 4900406 YPR165W RHO1
SGTC_2959 9079155 11 µM -0.623830288901347 0.263308507095146 no 2461 0.266369522834167 3554 16189457
SGTC_3282 9108498 15.4605 µM -0.624072261809382 0.263231816214306 no 2462 0.266290064750121 3522 16459645
SGTC_3158 9100007 49.47 µM -0.625146904280009 0.262891356994673 no 2463 0.265937323011119 3525 19297233
SGTC_3018 9082602 49.47 µM -0.62543381054152 0.2628004998517 no 2464 0.265843188663052 3556 17332089
SGTC_575 k072-0246 11.9 µM -0.625564034537178 0.262759265967001 no 2465 0.265800467559499 3568 6796779
SGTC_390 dec-rvkr-cmk 16.7 µM -0.625679232726329 0.262722792584564 no 2466 0.265762678702107 3563 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3020 9089140 49.47 µM -0.625889394052898 0.262656259197478 no 2467 0.265693745777836 3566 17217859
SGTC_2362 9071156 126 µM -0.626485109854664 0.262467712895104 no 2468 0.265498400249401 3579 653133
SGTC_1728 st035614 33.7865 µM -0.627179825579181 0.262247920296174 no 2469 0.265270683002148 3498 15945546
SGTC_2531 methyl deoxycholate 70.07 µM -0.628150148905171 0.261941089478699 no 2470 0.264952791824158 3518 16667744 Haematoxylin.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.628317979000068 0.261888037758904 no 2471 0.264897828035835 3570 3256 An antibiotic and ribosome inhibitor.
SGTC_839 0122-0028 230 µM -0.629098653673299 0.261641336027372 no 2472 0.264642235916649 3548 759448
SGTC_734 2023-0417 80 µM -0.629772032994894 0.261428636645221 no 2473 0.264421872995569 3536 3935732
SGTC_1875 nocodazole 6 µM -0.629952617125356 0.261371610892101 no 2474 0.26436279284787 3579 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3148 9097893 49.47 µM -0.630103544514607 0.261323955193568 no 2475 0.264313420395211 3479 17174100
SGTC_1508 1080-0625 72.9 µM -0.630238462552069 0.261281358266325 no 2476 0.264269289011256 3504 767111
SGTC_1137 ixabepilone 100 µM -0.631211229363619 0.260974337584872 no 2477 0.263951210284164 3585 154225 A novel microtubule stabilizer.
SGTC_2201 6605497 169.863 µM -0.631572835934692 0.260860256113659 no 2478 0.263833020660526 3557 670741
SGTC_625 k213-0058 121 µM -0.63262740932135 0.260527700516727 no 2479 0.263488491839382 3621 3655420
SGTC_535 2293-4129 48.2 µM -0.633099396097134 0.260378932074511 no 2480 0.263334368315231 3589 396118 YIL048W NEO1
SGTC_666 0272-0154 136 µM -0.633382716525314 0.260289651571854 no 2481 0.263241874400166 3563 6870312
SGTC_1612 st002233 45.4 µM -0.634439365141281 0.259956817502611 no 2482 0.262897063093399 3594 1035021
SGTC_255 tunicamycin 200.472 nM -0.635195433859494 0.259718797979966 no 2483 0.262650480461899 3532 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1799 st045822 46.1415 µM -0.635337792975827 0.259673994204777 no 2484 0.26260406500695 3569 3674992
SGTC_2295 7971645 200 µM -0.635575278627829 0.259599260742795 no 2485 0.26252664337919 3540 2978226 YKL099C UTP11
SGTC_1973 st070275 50.2 µM -0.635798831325238 0.259528921937262 no 2486 0.26245377464808 3531 17118334
SGTC_536 3852-0578 10.6 µM -0.636802161482743 0.259213354556986 no 2487 0.262126858998664 3602 2869208
SGTC_992 3909-8734 162 µM -0.63760894794946 0.258959748026539 no 2488 0.261864134743392 3556 4288319
SGTC_2545 solidagenone 89.61 µM -0.638648730611274 0.258633090496911 no 2489 0.261525736233746 3430 6708572 An anti ulcer agent
SGTC_1256 0570-0116 285 µM -0.639111007720992 0.258487930321673 no 2490 0.261375359721045 3554 410638
SGTC_517 1365-0151 113 µM -0.640291767512899 0.258117350202841 no 2491 0.260991465940364 3622 768657
SGTC_2890 9046729 58.44 µM -0.640350184932505 0.258099023116481 no 2492 0.260972480543136 3485 903329
SGTC_1413 3910-0535 34.4 µM -0.640851742678778 0.25794169898557 no 2493 0.26080950577191 3583 2876951
SGTC_1314 1222-0010 41.1 µM -0.641244427462524 0.257818559880422 no 2494 0.260681944431217 3567 3526027
SGTC_563 tetrahydrosecaminediol 614 µM -0.643979396837204 0.256961768095713 no 2495 0.259794397175112 3642 334274 A psychoactive constituent of the cannabis plant.
SGTC_2853 9015042 58.44 µM -0.645645542306201 0.25644053691294 no 2496 0.259254467999868 3541 6457456
SGTC_3231 9132313 49.47 µM -0.646562527510032 0.256153905640095 no 2497 0.25895755844269 3577 4905967
SGTC_568 1193-0097 7.48 µM -0.64764622144016 0.255815380058907 no 2498 0.258606897355842 3515 3646150
SGTC_2570 licareol 100 µM -0.649037848296521 0.255381004762268 no 2499 0.258156956354998 3537 443158
SGTC_2718 lomofungin 53.02 µM -0.650201138925044 0.255018197181264 no 2500 0.257781152739471 3621 5351222 A RNA synthesis inhibitor.
SGTC_916 4466-0038 42 nM -0.651451108570842 0.254628656863122 no 2501 0.257377663970123 3656 5722064 YGL116W CDC20
SGTC_2137 5261020 140 µM -0.651777604219496 0.254526959173924 no 2502 0.257272325630602 3594 763655
SGTC_361 000s-0510 1.45 µM -0.653544950250178 0.2539768313435 no 2503 0.256702510313463 3582 660
SGTC_2560 caryophyllene 100 µM -0.654852590277102 0.253570199722154 no 2504 0.256281333514356 3632 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_718 1130-0073 349 µM -0.654965276008841 0.253535174301344 no 2505 0.256245055517138 3676 6740020
SGTC_971 1315-0384 26.7 µM -0.656148192525291 0.253167649000039 no 2506 0.255864389494479 3599 6769120
SGTC_2148 5546263 113.568 µM -0.656872213658559 0.252942838144506 no 2507 0.255631543047018 3583 792097
SGTC_1755 st041960 45.185 µM -0.657100665897261 0.252871924811444 no 2508 0.255558095387141 3612 2257073
SGTC_2852 9023854 51.95 µM -0.658383078698763 0.252474048338181 no 2509 0.255146002892244 3658 19798528
SGTC_2831 7999036 19.48 µM -0.658820504808936 0.252338409685342 no 2510 0.255005519243532 3613 2988270
SGTC_1721 st082152 9.2685 µM -0.661644758887254 0.251463580408991 no 2511 0.254099457656234 3588 5296051
SGTC_1750 st081859 2.357 µM -0.661709656821258 0.251443496748353 no 2512 0.254078657325387 3631 5291695
SGTC_1846 st056244 14.8 µM -0.663144927634425 0.250999546964769 no 2513 0.253618869428121 3602 5393182
SGTC_2205 7238770 200 µM -0.663761244098339 0.250809038841624 no 2514 0.253421567135863 3627 279867
SGTC_1230 0170-0365 3.77 µM -0.664829109355503 0.250479134857902 no 2515 0.253079900932397 3691 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_768 0384-0033 77.3 µM -0.666229068436241 0.25004698311867 no 2516 0.252632347816975 3612 3965305 YMR134W ERG29
SGTC_1196 1588-0294 184 µM -0.666351631151444 0.250009168217833 no 2517 0.25259318558113 3610 6144269
SGTC_3040 9091894 49.47 µM -0.666413143889711 0.249990190522089 no 2518 0.252573531735939 3548 25236966
SGTC_3176 9106582 49.47 µM -0.667428245171698 0.249677125435945 no 2519 0.252249314585641 3534 17018027
SGTC_1118 chelidonine 707.474 nM -0.667554022844046 0.249638349132748 no 2520 0.252209157251082 3639 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_275 trichlorophene 5.69 µM -0.668754649854786 0.249268365983162 no 2521 0.251825999980433 3655 62616
SGTC_623 k072-0108 16.9 µM -0.668800466220279 0.249254253068586 no 2522 0.251811384648529 3599 5382803
SGTC_3297 9117502 71.43 µM -0.670001870101284 0.248884333713915 no 2523 0.251428299024952 3622 7453720
SGTC_1345 1488-0192 31.4 µM -0.671445543544899 0.248440204977171 no 2524 0.250968369891284 3643 658348
SGTC_886 0866-0150 153 µM -0.671692083751177 0.248364402099844 no 2525 0.250889871022171 3659 271463
SGTC_2519 cryptotanshinone 88.04 µM -0.673381771604597 0.247845211499228 no 2526 0.25035222116196 3616 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1305 1181-0477 144 µM -0.675677497521177 0.247140732888371 no 2527 0.249622712961459 3640 6252086
SGTC_1769 st044406 64.4 µM -0.675979879016461 0.247048022390343 no 2528 0.249526710031984 3640 670903
SGTC_127 0180-0333 59.125 µM -0.676634286314355 0.246847444117931 no 2529 0.249319009818371 3616 771601
SGTC_1371 2421-0008 32.7 µM -0.677223808441357 0.246666828053062 no 2530 0.249131982022687 3619 2827552
SGTC_3019 9081971 49.47 µM -0.679389925213367 0.246003787771684 no 2531 0.248445415861004 3686 16451803
SGTC_497 capsazepine 133 µM -0.679402870393495 0.245999828176624 no 2532 0.248441315827022 3622 2733484 A calcium channel blocker.
SGTC_3338 9144300 39.5675 µM -0.679689158429752 0.245912268827732 no 2533 0.248350651089878 3632 4901274
SGTC_3150 9097574 49.47 µM -0.680128677803173 0.245777877217844 no 2534 0.248211493756094 3625 17217476
SGTC_1414 3917-0015 5.4 µM -0.680683503468765 0.245608284781221 no 2535 0.24803588839969 3624 6618702
SGTC_2046 4110841 106 µM -0.681296967583384 0.245420841641391 no 2536 0.24784180084356 3653 44119630 YMR134W ERG29
SGTC_542 3381-0244 89.3 µM -0.683478030528022 0.244755043739582 no 2537 0.247152413953342 3657 1112843
SGTC_2263 7948595 193.29 µM -0.684726886558129 0.244374252395055 no 2538 0.246758139763454 3644 2971371
SGTC_1269 0831-0796 3.05 µM -0.684975461580078 0.244298496973637 no 2539 0.246679702775653 3646 927758
SGTC_97 0535-0701 19.132 µM -0.686577241621004 0.243810644170276 no 2540 0.246174587019371 3606 2832013 YGL099W LSG1
SGTC_2125 5246583 200 µM -0.687157254741292 0.243634119821374 no 2541 0.245991818784229 3680 835267
SGTC_1383 3049-0032 20.7 µM -0.688961545559196 0.243085433683971 no 2542 0.245423733576433 3686 712864
SGTC_365 0121-0052 13.6 µM -0.689293745528048 0.242984484328381 no 2543 0.245319216537316 3669 3101739
SGTC_1034 k072-0165 12.7 µM -0.689484163024874 0.242926630239972 no 2544 0.2452593180103 3657 5835461
SGTC_1295 1013-0063 9.78 µM -0.689811920432148 0.24282706595438 no 2545 0.245156235681625 3669 6826038
SGTC_887 0885-0007 9.62 µM -0.690091243028331 0.242742232353309 no 2546 0.245068404880858 3686 5719458
SGTC_519 k048-0011 62.8 µM -0.690220233909999 0.242703061700847 no 2547 0.245027850422898 3670 6836379
SGTC_2283 7944793 200 µM -0.691100044711594 0.242435980900421 no 2548 0.244751336099518 3655 2970533
SGTC_252 miconazole 1.30953 nM -0.691600030739041 0.242284273035378 no 2549 0.244594271186761 3622 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_131 0141-0277 33.849 µM -0.693157272161894 0.241812098133761 no 2550 0.244105429576339 3625 1547771
SGTC_1681 tripelennamine 100 µM -0.694077992060134 0.241533159519645 no 2551 0.243816649735666 3661 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1507 4075-3230 155 µM -0.694454302889746 0.241419203811591 no 2552 0.243698674563335 3600 659771
SGTC_1836 st055642 81 µM -0.696235708086702 0.240880149300438 no 2553 0.243140614370789 3663 8571
SGTC_3047 9092122 49.47 µM -0.698594547420781 0.24016737150121 no 2554 0.242402726123306 3642 17173831
SGTC_2347 9049783 174.81 µM -0.699010605973595 0.240041769168511 no 2555 0.24227270135668 3661 6467988 YPL169C MEX67
SGTC_3135 9127742 49.47 µM -0.702869327491622 0.238878582528117 no 2556 0.241068593832867 3703 3643468
SGTC_3001 9076041 71.4286 µM -0.704068307721838 0.238517786425131 no 2557 0.240695117769856 3692 16004211
SGTC_1204 4049-0315 18.3 µM -0.704377139699802 0.238424901310012 no 2558 0.240598969256435 3722 588402
SGTC_1247 0448-0043 5.84 µM -0.706125742820318 0.237899360586596 no 2559 0.240054972036524 3738 3089013 YGL099W LSG1
SGTC_53 0973-0023 39.979 µM -0.706202159634473 0.237876408092783 no 2560 0.24003121377185 3651 674768
SGTC_331 k048-0133 24.5 µM -0.706574003852261 0.237764738590222 no 2561 0.239915624355259 3655 6813582
SGTC_733 4069-0007 56.1 µM -0.706919358927619 0.237661049870955 no 2562 0.239808296403129 3720 5717425 YNL287W SEC21
SGTC_2657 nystatin 74.44 µM -0.709542741698095 0.23687422124284 no 2563 0.238993868741163 3704 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1650 st011916 45.8 µM -0.709871927210226 0.236775590187206 no 2564 0.238891780181071 3667 242528
SGTC_2469 5655019 90.81 µM -0.710048258758918 0.236722766755442 no 2565 0.2388371052218 3719 2788239
SGTC_1479 0549-0158 134 µM -0.710617132805067 0.236552394031058 no 2566 0.2386607616437 3741 5440202
SGTC_530 4358-1714 28 µM -0.710705382063185 0.236525970208763 no 2567 0.238633411903098 3755 1564641
SGTC_440 fluspirilene 35.1 µM -0.712840990469806 0.235887016301812 no 2568 0.237972078773089 3745 3396 An atypical antipsychotic.
SGTC_103 0844-0104 51.839 µM -0.713029197095229 0.235830752308756 no 2569 0.237913845105243 3723 5375804
SGTC_1914 st062367 72.6 µM -0.713140746633864 0.23579740829037 no 2570 0.237879333861971 3699 978205
SGTC_2823 7987624 58.44 µM -0.713508317240341 0.23568755369933 no 2571 0.237765634140989 3714 2239440
SGTC_730 1436-0052 41.2 µM -0.713627274785933 0.23565200730423 no 2572 0.237728843678633 3716 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2008 4012253 172 µM -0.71406697301491 0.235520644190583 no 2573 0.237592883606813 3716 603940
SGTC_2162 5663267 200 µM -0.714313138750847 0.235447117992961 no 2574 0.237516784785202 3686 6456493
SGTC_1752 st044819 83.042 µM -0.715770919560011 0.23501195936378 no 2575 0.237066405791556 3684 441209 YML126C ERG13
SGTC_2011 4012611 177 µM -0.715851679951757 0.234987864771206 no 2576 0.237041468727765 3728 2049887
SGTC_2320 7373003 200 µM -0.7178249984117 0.234399556114875 no 2577 0.236432598784132 3732 5415828
SGTC_840 0245-0196 390 µM -0.720124046400507 0.233715166332636 no 2578 0.235724311643889 3776 3827528
SGTC_265 mycophenolic acid 32.932 µM -0.720352777959842 0.233647137246555 no 2579 0.235653908433338 3788 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1283 0922-0125 16.4 µM -0.721592890228016 0.233278495620817 no 2580 0.23527240581437 3719 3360884
SGTC_3215 9129942 49.47 µM -0.722664067795145 0.232960332317777 no 2581 0.234943148180443 3644 17682944
SGTC_780 0109-0199 192 µM -0.723177522459255 0.232807910481035 no 2582 0.234785413251224 3733 610414
SGTC_3161 9100388 49.47 µM -0.725522552404917 0.232112480392051 no 2583 0.234065757251033 3731 25236368
SGTC_2057 5236571 38.335 µM -0.725603341432383 0.232088542633397 no 2584 0.234040986047533 3709 54684039 YBR257W POP4
SGTC_20 0481-0013 4.944 µM -0.725671694356859 0.232068290760671 no 2585 0.234020029085411 3717 182045
SGTC_418 lividomycin a 100 µM -0.725858587073585 0.232012922475659 no 2586 0.233962733206993 3714 72394 An antibiotic.
SGTC_1933 st074711 15.9 µM -0.725929924822455 0.231991790104285 no 2587 0.233940865174744 3702 17250958
SGTC_2525 harmine 47.85 µM -0.726282246854327 0.231887437516776 no 2588 0.233832880203635 3711 5280953 A monoamine oxidase inhibitor
SGTC_138 0850-0259 40.9225 µM -0.726327474155642 0.231874043751057 no 2589 0.233819020258885 3741 6813004
SGTC_2926 9010726 65.15 µM -0.726501799325074 0.231822422538141 no 2590 0.233765602422815 3727 2994293
SGTC_2067 5224629 34.075 µM -0.727177687824076 0.231622338805274 no 2591 0.233558556302577 3694 2835000
SGTC_502 l-744,832 89.3 µM -0.728605666287027 0.231199930014064 no 2592 0.233121455717285 3677 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_54 0159-0055 9 µM -0.728719186992623 0.231166368027021 no 2593 0.233086726815353 3743 3319099
SGTC_1638 st008370 60.6 µM -0.729922324985976 0.230810831752211 no 2594 0.232718832587297 3726 24207134
SGTC_552 k242-0005 476 µM -0.730118213288836 0.230752974216419 no 2595 0.232658964638537 3755 4088318
SGTC_1483 3453-0561 55.9 µM -0.730365143336234 0.230680052543414 no 2596 0.232583509363369 3715 4546991
SGTC_1211 1056-0033 32.3 µM -0.732743245510956 0.229978427279246 no 2597 0.231857521258246 3729 6741922
SGTC_1142 3253-1408 9.78 µM -0.733227868512743 0.229835592785232 no 2598 0.231709730301389 3696 256655
SGTC_610 4215-0184 155 µM -0.734389610864403 0.229493391054162 no 2599 0.231355658404136 3765 5605015
SGTC_1120 ficusin 1.78878 µM -0.737337785099423 0.228626262528342 no 2600 0.230458479791831 3831 6199 A DNA cross-linker.
SGTC_386 1509-0011 3.07 µM -0.737338967402552 0.228625915154224 no 2601 0.230458120387816 3775 3107280
SGTC_403 arphamenine a 50 µM -0.737759292124534 0.228502437751879 no 2602 0.230330367266197 3697 5487158 An arginine aminopeptidase inhibitor.
SGTC_2064 5220758 200 µM -0.738500028757369 0.22828492521639 no 2603 0.230105324850325 3765 788518
SGTC_302 1094-0063 18.9 µM -0.739005156020436 0.228136664618361 no 2604 0.229951933244105 3696 5440289
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.739353622963301 0.228034417173022 no 2605 0.229846147924913 3797 6728940
SGTC_1277 0873-0036 22 µM -0.739543713559844 0.227978651506806 no 2606 0.229788452949872 3788 5965735
SGTC_511 blebbistatin 171 µM -0.740323660518267 0.227749923768614 no 2607 0.229551813792047 3775 3476986 A myosin inhibitor.
SGTC_1351 1496-0003 46.5 µM -0.74080685145842 0.227608287707079 no 2608 0.229405280169147 3759 3891978
SGTC_1727 st034309 9.9045 µM -0.741034651997205 0.227541530541903 no 2609 0.22933621503021 3772 870305
SGTC_1977 st070720 65.3 µM -0.74226259109976 0.227181871784247 no 2610 0.228964126200122 3763 682188
SGTC_1212 0520-0165 585 µM -0.74282911724377 0.227016046480555 no 2611 0.228792572297627 3848 5403258
SGTC_3187 9109394 49.47 µM -0.744690390820699 0.226471722256744 no 2612 0.228229454765037 3698 17098090
SGTC_565 1418-0001 44.5 µM -0.74474024710467 0.226457152068188 no 2613 0.228214381757564 3777 2862145
SGTC_883 0850-0245 24.6 µM -0.746907942643621 0.225824168576738 no 2614 0.22755956560816 3830 6823229 YPR165W RHO1
SGTC_2906 7926292 26.41 µM -0.747052695166601 0.225781935416317 no 2615 0.227515876570586 3726 2966319
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.747753596176451 0.225577502941168 no 2616 0.227304398270961 3709 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1821 st053465 65.6 µM -0.7490078119815 0.225211946167718 no 2617 0.226926248476573 3736 675086
SGTC_859 0439-0102 54.6 µM -0.749028450681142 0.225205933569966 no 2618 0.226920028816074 3745 610143
SGTC_2462 5162487 171.77 µM -0.749187760357665 0.225159525517669 no 2619 0.226872022626669 3683 2259986
SGTC_2249 haloperidol 116.36 µM -0.749753609882072 0.224994733292082 no 2620 0.226701556519515 3748 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2967 9089538 49.85 µM -0.751585585053691 0.224461676732252 no 2621 0.226150157359066 3763 728216
SGTC_976 1348-1067 47.6 µM -0.751742184011169 0.224416143830947 no 2622 0.226103058428508 3792 5310671 YGL099W LSG1
SGTC_1259 0671-0132 43 µM -0.751758240360644 0.224411475563772 no 2623 0.226098229610817 3717 X1259
SGTC_3106 9121286 49.47 µM -0.754868624059837 0.223508194108896 no 2624 0.225163906704693 3759 15943471
SGTC_430 0958-0115 16.4 µM -0.755715485706872 0.223262617080081 no 2625 0.224909898708784 3751 6833180
SGTC_2121 5257820 149.641 µM -0.756350385283276 0.223078606608669 no 2626 0.224719573278341 3834 791256
SGTC_1965 Pectolinarigenin 58.4 µM -0.758893571157084 0.22234239134617 no 2627 0.223958112491688 3761 5320438 An anti-inflammatory.
SGTC_1467 k284-1082 293 µM -0.759644930276217 0.22212514935877 no 2628 0.223733427297695 3737 3334705
SGTC_1804 st050076 49.1 µM -0.760181948585303 0.221969954432504 no 2629 0.223572916786127 3795 3895976
SGTC_179 1273-0063 6.77 µM -0.76027465990615 0.221943167710163 no 2630 0.223545212738729 3771 3108139
SGTC_55 0767-0285 6.563 µM -0.761495043574602 0.221590739099946 no 2631 0.223180719087885 3718 3116166
SGTC_1248 0469-0687 58.6 µM -0.762819011867076 0.221208758759904 no 2632 0.222785670582162 3780 4017482
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.763472359214508 0.221020399298087 no 2633 0.222590870326398 3752 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1278 0874-0585 172 µM -0.76382856689881 0.220917743615838 no 2634 0.222484705336408 3838 766306
SGTC_236 1509-0011 5.31 µM -0.766672566244555 0.220099109471121 no 2635 0.221638109277229 3835 3107280
SGTC_2379 9035213 200 µM -0.769489431045715 0.219290003842207 no 2636 0.220801408180732 3773 646551
SGTC_2985 9022375 71.43 µM -0.769692108840513 0.219231853435288 no 2637 0.220741276069844 3775 4939335
SGTC_1684 st024538 14.6195 µM -0.771263000437194 0.218781448680073 no 2638 0.220275529228757 3767 6732859
SGTC_118 0083-0097 135.343 µM -0.772526579902963 0.218419542946141 no 2639 0.21990130525646 3843 5207356
SGTC_3260 9137109 49.47 µM -0.772981725093697 0.218289267908392 no 2640 0.219766598068897 3651 17478346
SGTC_2020 4017018 200 µM -0.774136828824115 0.217958846584573 no 2641 0.219424940185381 3876 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2863 9028737 58.44 µM -0.775264050032909 0.217636679355273 no 2642 0.219091823832809 3793 6460917
SGTC_3308 9128332 17.569 µM -0.775567410275781 0.217550023953923 no 2643 0.219002224514871 3780 17332805 YDL196W YDL196W
SGTC_2144 5628481 200 µM -0.775953095268169 0.217439881097906 no 2644 0.218888340509479 3786 2818399
SGTC_2689 tacrolimus 100 µM -0.776048949423854 0.217412512328181 no 2645 0.218860042244404 3807 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2456 5770359 74.46 µM -0.776953638052803 0.217154298983721 no 2646 0.218593061869957 3775 3118787
SGTC_3058 9093861 49.47 µM -0.777139254976428 0.217101342705538 no 2647 0.218538308119069 3798 17217477
SGTC_1140 3229-1848 2.98 µM -0.777565515944199 0.216979759226838 no 2648 0.218412598472265 3825 2849525
SGTC_673 1082-0474 110 µM -0.778327210293797 0.216762597266617 no 2649 0.218188069097363 3809 3098046
SGTC_2884 9058502 51.95 µM -0.781151892932893 0.215958367558348 no 2650 0.217356582026429 3792 6471554
SGTC_732 3970-1727 52.7 µM -0.781484684961437 0.215863730622711 no 2651 0.217258740402735 3818 1275699
SGTC_3085 9117376 49.47 µM -0.781785490167451 0.215778210545935 no 2652 0.217170324870394 3899 16480349
SGTC_3343 9148379 18.9835 µM -0.783745720551314 0.21522139068483 no 2653 0.216594664589591 3860 1955036
SGTC_1103 duloxetine 36.1 µM -0.783795813513132 0.215207172296141 no 2654 0.216579965380711 3906 60835 A selective serotonin reuptake inhibitor.
SGTC_2226 7298446 200 µM -0.783915857155473 0.215173101321771 no 2655 0.216544742290336 3780 3283010
SGTC_446 go6976 132 µM -0.785443844813919 0.214739699119856 no 2656 0.216096691280174 3782 3501 A protein kinase C inhibitor.
SGTC_1808 st050063 61.5 µM -0.785986689090252 0.21458584762532 no 2657 0.215937642695962 3787 4011993
SGTC_2389 9091542 195.52 µM -0.78757505394469 0.214136045632324 no 2658 0.215472655565177 3820 3626624 YOL127W RPL25
SGTC_772 k072-0172 35.3 µM -0.790949604013126 0.213182244880439 no 2659 0.21448670022733 3850 5861980
SGTC_2816 7982706 58.44 µM -0.79120106864859 0.213111268916601 no 2660 0.214413333998128 3878 2981853
SGTC_11 0438-0307 1.3 µM -0.792666000838322 0.212698065532052 no 2661 0.213986221984751 3816 4011476
SGTC_2595 hexamethylquercetagetin 100 µM -0.792691366716877 0.212690914875066 no 2662 0.213978830736542 3791 386331
SGTC_2412 st077135 33.4 µM -0.792755455928883 0.212672848711595 no 2663 0.213960156734085 3913 13258915
SGTC_2461 5755302 26.15 µM -0.794432927215108 0.212200303628922 no 2664 0.213471720804887 3828 2788904
SGTC_291 SEC14.278 35.5 µM -0.79463836674871 0.212142473356071 no 2665 0.213411946865531 3804 1068044
SGTC_2325 6158266 200 µM -0.79501733274512 0.212035820370459 no 2666 0.213301709898877 3868 3623240
SGTC_2331 7980721 200 µM -0.796377423316892 0.211653306284532 no 2667 0.212906348273558 3799 2981221
SGTC_1553 gossypol 38.6 µM -0.797806287852603 0.211251885490977 no 2668 0.212491455919185 3708 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3160 9100216 49.47 µM -0.798269257011105 0.211121916103235 no 2669 0.212357127222056 3736 17191039
SGTC_1026 k007-1105 30.6 µM -0.799568855091924 0.210757330277345 no 2670 0.211980319159722 3828 7066794
SGTC_754 3474-0146 171 µM -0.80016612178444 0.210589898589054 no 2671 0.211807277703577 3797 24762078
SGTC_918 glabranin 770.725 nM -0.800482172093849 0.210501331837511 no 2672 0.211715744342926 3870 124049 Also referred to as licorice root.
SGTC_608 k048-0125 159 µM -0.80131001619055 0.210269448808323 no 2673 0.211476096858808 3860 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1096 rimcazole 32.2 µM -0.801649767432711 0.210174326315626 no 2674 0.211377790357172 3762 18528119 A dopamine reuptake inhibitor.
SGTC_448 monastrol 171 µM -0.801933232416101 0.210094982018746 no 2675 0.211295790684039 3750 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2697 mebhydrolin 72.4 µM -0.803959284642605 0.209528385078326 no 2676 0.210710244815014 3869 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1405 3909-7894 12 µM -0.804302086717145 0.209432607530729 no 2677 0.210611266417075 3852 7104060
SGTC_744 1594-0068 283 µM -0.80446490713568 0.209387125172707 no 2678 0.21056426428669 3853 668392
SGTC_2004 4023728 41.89 µM -0.804575533570627 0.209356226031268 no 2679 0.210532332749481 3851 360084 YDR527W RBA50
SGTC_1565 sinapyl alcohol 95.1 µM -0.804664024644923 0.209331511463622 no 2680 0.210506792473312 3865 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3065 9113888 49.47 µM -0.805485219206084 0.209102242918163 no 2681 0.210269866215189 3872 16648368
SGTC_424 splitomicin 100 mM -0.807487418989862 0.208543870739447 no 2682 0.209692859985031 3943 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2969 9091408 28.7 µM -0.809555747641951 0.207967980761055 no 2683 0.20909777514992 3805 4286311
SGTC_1343 1487-0095 224 µM -0.809814635124767 0.207895964238368 no 2684 0.209023359970218 3813 4560101 YGL055W OLE1
SGTC_837 0091-0265 12.5 µM -0.810841965842879 0.207610329741056 no 2685 0.208728215591504 3821 759367
SGTC_3071 9117417 49.47 µM -0.812183483828445 0.207237689322038 no 2686 0.208343177577634 3786 45595590 YGL055W OLE1
SGTC_2804 7954240 19.48 µM -0.813053132941422 0.206996333837061 no 2687 0.208093797783911 3895 828705
SGTC_1866 st057638 64 µM -0.813403859741323 0.206899043001102 no 2688 0.207993273558838 3826 688802
SGTC_2807 7945238 51.95 µM -0.81456086473274 0.206578284347313 no 2689 0.207661859725498 3913 17148797
SGTC_2058 5236698 133 µM -0.816017262549974 0.206174943460978 no 2690 0.207245131310737 3854 766665
SGTC_2238 6671620 73.2395 µM -0.816444137034624 0.206056811595108 no 2691 0.207123080772148 3809 729941
SGTC_1790 st045711 43.5 µM -0.817016302112626 0.205898535450871 no 2692 0.206959555935629 3833 585119
SGTC_604 1000-0114 314 µM -0.817027290204351 0.205895496557176 no 2693 0.206956416285797 3854 1572745
SGTC_1793 st048256 72.231 µM -0.819848952067898 0.205116011817444 no 2694 0.206151110404612 3733 672022
SGTC_2669 eugenol 100 µM -0.820419327076072 0.20495865894014 no 2695 0.205988550673145 3819 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_279 1273-0055 2.93 µM -0.820825455440133 0.20484666155328 no 2696 0.205872848410828 3880 2847562
SGTC_808 0711-0032 135 µM -0.821108587185132 0.204768604286464 no 2697 0.205792209575609 3800 4252555
SGTC_1374 2889-5571 141 µM -0.824001053667024 0.203972187296412 no 2698 0.204969479633191 3897 2853281
SGTC_2479 5617353 43.85 µM -0.824411361013752 0.203859362191193 no 2699 0.204852930837381 3892 2731746
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.824556228125238 0.203819535946063 no 2700 0.204811790398488 3853 6312947
SGTC_2524 avocatin b 10.57 µM -0.824672328467606 0.203787621485702 no 2701 0.204778822907635 3837 6710748
SGTC_1784 st039334 36.3 µM -0.826681803725984 0.203235715215897 no 2702 0.204208718790381 3922 3496984
SGTC_3063 1327-0034 4 µM -0.827839849203353 0.202918061384233 no 2703 0.203880601826717 3762 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_57 miconazole 162.5 nM -0.82852307614898 0.202730790246144 no 2704 0.203687165910525 3822 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1209 2323-2347 50.3 µM -0.831511397487992 0.201912911809818 no 2705 0.202842396141121 3826 5412760
SGTC_1913 st060213 96.1 µM -0.831844027327102 0.201821996149445 no 2706 0.202748494502746 3914 688959
SGTC_977 1348-1378 135 µM -0.834935056891798 0.200978316948171 no 2707 0.201877137484439 3867 X977
SGTC_865 0488-0499 301 µM -0.835242456521351 0.200894529768563 no 2708 0.20179060468937 3839 9634651
SGTC_1885 st057546 99.9 µM -0.835941227960466 0.200704145303904 no 2709 0.201593983633243 3949 702008
SGTC_1744 st037937 38.9 µM -0.836096767237588 0.200661782437751 no 2710 0.201550233446988 3956 1016152
SGTC_186 3455-3465 67.277 µM -0.836771176197285 0.200478161702635 no 2711 0.201360601085423 3835 755278
SGTC_2787 5284540 71.43 µM -0.838222686425719 0.200083302776083 no 2712 0.200952823979608 3931 736958
SGTC_3076 9116187 49.47 µM -0.838571556395895 0.199988468304098 no 2713 0.200854888795503 3880 27241210
SGTC_2932 9016711 44.54 µM -0.840635746740855 0.199427905881416 no 2714 0.200276013189136 3905 7117328
SGTC_3342 9147791 14.508 µM -0.841606265416476 0.199164673953598 no 2715 0.200004190540216 3815 1838168
SGTC_1322 1348-1070 12 µM -0.841913061270201 0.199081505857016 no 2716 0.199918309390959 3833 6758089
SGTC_2303 7774051 200 µM -0.842893011886784 0.198815995039974 no 2717 0.199644141078646 3848 2953184
SGTC_2493 resveratrol 26.09 µM -0.844895392296882 0.198274128136087 no 2718 0.199084623657977 3776 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1113 artemisinin 1.17947 µM -0.845090909554048 0.198221266753358 no 2719 0.199030041699285 3915 2240 An anti-malaria and mitochondrial poison.
SGTC_1830 st055982 50.3 µM -0.847476792782572 0.197576888603655 no 2720 0.198364708556172 3805 455313 An antimicrobial agent.
SGTC_2946 9065502 71.43 µM -0.850255069740531 0.196828130890352 no 2721 0.197591645276617 3744 16489101
SGTC_1751 st044839 27.194 µM -0.850476015772223 0.196768658820322 no 2722 0.197530244704113 3847 5291326
SGTC_2330 7979373 200 µM -0.850780217156034 0.196686794705354 no 2723 0.197445726470093 3859 1863007
SGTC_2639 lactacystin 53 µM -0.851493378702892 0.196494955565414 no 2724 0.197247669938162 3934 3870 A proteasome inhibitor.
SGTC_219 mitoxanthrone 164.414 µM -0.853517268065119 0.195951150849359 no 2725 0.196686257890941 3881 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3127 9126946 49.47 µM -0.854247070003166 0.19575528244875 no 2726 0.196484053856104 3902 27243249
SGTC_2814 7977482 42.97 µM -0.854302597166993 0.195740384618619 no 2727 0.196468674269876 3989 6456762
SGTC_1051 3253-3903 78 µM -0.854626670803167 0.195653450021728 no 2728 0.196378928820535 3903 5509239
SGTC_2407 paclitaxel 400 µM -0.85474504579314 0.195621701102836 no 2729 0.196346153527342 4082 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2038 4100038 30.985 µM -0.857975663138941 0.194756437175209 no 2730 0.195452951000291 3920 3596803
SGTC_1570 verbenone 133 µM -0.858420277011534 0.194637537701801 no 2731 0.195330217444806 3949 29025 A natural terpanoid with antifungal properties.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.859514508286408 0.194345104494758 no 2732 0.195028359559992 3879 16623 A steroid.
SGTC_2327 6189656 200 µM -0.859919515441494 0.194236934236416 no 2733 0.194916705032458 3998 5349088
SGTC_1832 st054113 55 µM -0.862835067047285 0.193459324417444 no 2734 0.194114077896385 3918 1251267
SGTC_745 0469-0705 296 µM -0.862912405654235 0.193438723246736 no 2735 0.194092814668333 4005 3486736
SGTC_1382 3002-2117 298 µM -0.863227644383063 0.193354764972369 no 2736 0.194006158625444 3971 1497314
SGTC_2950 9072895 21.46 µM -0.863310805380361 0.19333262021491 no 2737 0.193983302411056 3871 17332245
SGTC_1225 1216-0074 20.6 µM -0.866161682540345 0.192574402679181 no 2738 0.193200751488605 3922 4241466
SGTC_2375 9072683 200 µM -0.866975377434174 0.192358326748612 no 2739 0.192977750451136 3939 16798029
SGTC_3133 9127736 49.47 µM -0.867300248991793 0.192272098835069 no 2740 0.192888760151669 3867 27243420
SGTC_1340 1486-1359 257 µM -0.867703817600396 0.192165015959708 no 2741 0.192778247712841 3865 4309068
SGTC_2315 7733312 200 µM -0.867899700190984 0.192113053637413 no 2742 0.192724621554802 3865 726316
SGTC_2918 7977171 22.06 µM -0.869190627063274 0.191770820923267 no 2743 0.192371436609495 3849 2236483
SGTC_3214 9129694 49.47 µM -0.870564042433201 0.191407130122764 no 2744 0.191996118467035 3934 17158655
SGTC_2572 astragaloside iv 100 µM -0.870858438635503 0.191329226821947 no 2745 0.191915726125211 4014 45006101 An anti-inflammatory agent.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.873590446108096 0.190607208646526 no 2746 0.191170665486463 3934 442882
SGTC_1690 st023502 41.2 µM -0.874719058335364 0.190309426508052 no 2747 0.190863393830749 3916 24207482
SGTC_683 panaxydol 45 µM -0.875120589810348 0.190203552166889 no 2748 0.190754147522707 3920 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2156 5649887 115 µM -0.876446125814429 0.189854296711606 no 2749 0.190393776041078 3991 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_212 3807-4682 38.772 µM -0.876886228668629 0.189738424589541 no 2750 0.190274218456944 4009 3125501 YBL034C STU1
SGTC_395 anisomycin 6.25 µM -0.877006910208253 0.189706658648551 no 2751 0.190241442376455 3953 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2472 5377652 49.4 µM -0.878939635337628 0.189198370172892 no 2752 0.189717003351513 4026 1610903
SGTC_2335 9018011 154.17 µM -0.87915699917092 0.189141258039601 no 2753 0.189658078018813 3968 6458208
SGTC_176 1486-1328 72.834 µM -0.880114131154089 0.188889898876758 no 2754 0.189398742311456 4018 22310231
SGTC_2363 9053361 176 µM -0.881974040792783 0.188402043841002 no 2755 0.188895422750711 4012 6469797 YMR079W SEC14
SGTC_2788 5282734 71.43 µM -0.884619150721751 0.187709570445545 no 2756 0.188181037153158 4034 743706
SGTC_2403 6032726 181.2 µM -0.885616479447567 0.18744888464006 no 2757 0.187912114147286 4009 2881040
SGTC_2843 9000894 45.46 µM -0.887189787281693 0.187038102269905 no 2758 0.187488364947648 3865 2242070
SGTC_202 3594-0513 34.79 µM -0.889259676768989 0.186498514059172 no 2759 0.186931768571219 3952 708429
SGTC_2200 6600604 21.907 µM -0.892110968664486 0.185756806853474 no 2760 0.186166728133684 3926 2904777
SGTC_3100 9120536 49.47 µM -0.89216600672289 0.185742507815391 no 2761 0.186151979789127 3796 16421196
SGTC_2212 7123476 200 µM -0.895746544499428 0.184813741821782 no 2762 0.185194072753525 3921 1085715
SGTC_2445 5742597 35.57 µM -0.899385712970386 0.183872730952802 no 2763 0.184223623245686 3931 1774255
SGTC_1390 3413-2614 145 µM -0.899672038444645 0.183798820172631 no 2764 0.184147403957788 4004 3421432
SGTC_3105 9121040 49.47 µM -0.900168046073788 0.183670826781635 no 2765 0.18401541414661 3788 41448907
SGTC_3034 9090421 49.47 µM -0.900309936501648 0.183634222569034 no 2766 0.183977667317659 3845 17173761
SGTC_477 mead ethanolamide 10 µM -0.901188655349465 0.183407636148376 no 2767 0.183744010883678 3840 16061185
SGTC_969 1313-0238 134 µM -0.901760568956684 0.183260256199826 no 2768 0.183592035103121 3988 5212874
SGTC_2310 7668677 200 µM -0.902717234046605 0.183013892415686 no 2769 0.183337993685829 3974 2197143
SGTC_1119 parthenolide 318.541 nM -0.903132299134909 0.182907067692007 no 2770 0.183227841794276 4088 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1615 st002656 86.5 µM -0.90702173540702 0.181907940554538 no 2771 0.182197651662515 3971 1584458
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.908078779205448 0.18163699574359 no 2772 0.181918300637447 4028 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_33 0986-0033 35.816 µM -0.908283615678332 0.181584520635274 no 2773 0.181864198327084 3885 2848082
SGTC_206 4546-0025 72.014 µM -0.910475950337374 0.181023481584347 no 2774 0.181285779658482 4032 6620745 YIL048W NEO1
SGTC_2385 9074692 200 µM -0.91060332335373 0.180990919050801 no 2775 0.181252209411449 4007 17046906
SGTC_1882 5615643 20 µM -0.912616971151736 0.180476623719704 no 2776 0.180722012701206 3926 2253075
SGTC_2218 6965428 192.983 µM -0.913114906312935 0.180349590193403 no 2777 0.180591055675128 3879 675684
SGTC_896 0964-0007 44.5 µM -0.913351148403262 0.180289339593841 no 2778 0.180528944789158 3922 6756758
SGTC_2910 7948405 25.97 µM -0.919739836309507 0.178664776234917 no 2779 0.178854364957855 3894 2971328
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.921371908867976 0.178251243348726 no 2780 0.178428144854677 3998 77254
SGTC_1899 st063254 59.6 µM -0.92158771536716 0.17819660770708 no 2781 0.178371834349336 3939 3093813
SGTC_2052 5265182 7.135 µM -0.92179626261386 0.178143819916926 no 2782 0.178317428644118 4009 1239884
SGTC_1644 st010134 20.9 µM -0.922945388133693 0.177853128377932 no 2783 0.178017832912864 3950 3818134
SGTC_1503 4585-0012 61.3 µM -0.924754515815058 0.177396084349371 no 2784 0.177546807454622 4067 2922052
SGTC_1124 fisetin 1.16336 µM -0.925240090829204 0.177273538764957 no 2785 0.177420516899577 4033 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_827 3253-0474 693 µM -0.926858371897695 0.176865515867811 no 2786 0.177000036587579 4036 5402065
SGTC_1700 st030840 7.9285 µM -0.927824149472062 0.176622294021205 no 2787 0.176749397474531 4043 5499307
SGTC_968 1309-0633 340 µM -0.92918024494051 0.176281131532091 no 2788 0.176397841774819 4053 3761976
SGTC_895 0964-0006 13.7 µM -0.932724091651236 0.175391551445476 no 2789 0.17548122132274 3997 6738897
SGTC_3354 9151612 71.43 µM -0.933401871593092 0.175221739183216 no 2790 0.17530625721291 4036 27261949
SGTC_2129 girgensonine 121.053 µM -0.933642864579138 0.175161385483089 no 2791 0.175244073240382 4028 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3313 9133968 57.047 µM -0.935055606232973 0.174807847135342 no 2792 0.174879821675904 3998 1494643
SGTC_2891 9063876 19.48 µM -0.936807155700293 0.17437015154556 no 2793 0.174428881915753 4005 6472478
SGTC_2678 equilin 100 µM -0.936874624085381 0.174353305774159 no 2794 0.174411526837481 4025 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.937210019700208 0.174269578226204 no 2795 0.174325268382095 4051 368090
SGTC_1206 3978-0017 132 µM -0.938461726404446 0.173957330102259 no 2796 0.174003588576269 4122 3873677
SGTC_1795 st049545 62.3 µM -0.939319686355627 0.173743510828667 no 2797 0.173783317047864 3932 5291882
SGTC_1733 st037357 54.9 µM -0.940124647321782 0.173543051947467 no 2798 0.173576813751518 3933 1272339 YGL099W LSG1
SGTC_662 k832-1615 104 µM -0.940186607502417 0.17352762814888 no 2799 0.173560925068502 4052 5878478
SGTC_2255 7941087 197.44 µM -0.940512835758372 0.173446434270726 no 2800 0.173477284390996 4111 935561
SGTC_3157 9099274 49.47 µM -0.942181242943822 0.173031568048669 no 2801 0.173049927703414 4025 17217662
SGTC_2055 5235184 200 µM -0.942213634820509 0.173023519743651 no 2802 0.173041637279266 4093 2836034
SGTC_1560 lithocholic acid 53.1 µM -0.942645176707095 0.17291631867832 no 2803 0.172931211959709 3869 9903 A bile acid which acts as a detergent.
SGTC_551 k048-0028 34.9 µM -0.942663207970769 0.17291184038051 no 2804 0.1729265989979 4028 6836383
SGTC_2700 st077718 96.8 µM -0.943400694223258 0.172728739449551 no 2805 0.172737994111014 4008 904970
SGTC_3213 9129884 49.47 µM -0.94361499355666 0.172675557021099 no 2806 0.172683213751168 4030 17190742
SGTC_2745 rifampicin 24.3 µM -0.943825828155611 0.172623244620403 no 2807 0.172629329874742 4016 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2340 7987427 183.45 µM -0.945080763045174 0.172312078561401 no 2808 0.172308822779128 4051 2239331
SGTC_2602 kawain 100 µM -0.945360405962478 0.172242788781531 no 2809 0.17223745446553 4026 5369129
SGTC_3314 9135860 59.4275 µM -0.947399839877596 0.171737996628233 no 2810 0.171717536346423 4033 25252478
SGTC_2742 clothiapine 36.27 µM -0.950723070707872 0.170917471084127 no 2811 0.170872486742491 3985 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2204 7233102 200 µM -0.950908289236611 0.170871813435843 no 2812 0.170825466763212 3929 2172480
SGTC_3002 9075603 71.4286 µM -0.953493406256872 0.170235378954373 no 2813 0.170170067725208 3978 20105405
SGTC_725 1497-0963 19 µM -0.953893345789236 0.170137052972129 no 2814 0.170068816044539 4127 3549977
SGTC_788 1182-0090 188 µM -0.954039015053137 0.170101248918298 no 2815 0.170031946920042 4089 5715185
SGTC_2140 5586273 200 µM -0.956327312278214 0.169539442066786 no 2816 0.169453447664516 4014 854421
SGTC_383 2324-0395 7.37 µM -0.956362176790651 0.169530891591474 no 2817 0.169444643425535 4037 3146421
SGTC_319 1348-1596 45.5 µM -0.956947368793616 0.169387415329074 no 2818 0.169296910321891 4144 5380505
SGTC_785 1270-0111 65.3 µM -0.957132187344825 0.169342118065856 no 2819 0.169250269627149 3977 6741994
SGTC_2351 9026858 72.31 µM -0.957739902238864 0.169193227765425 no 2820 0.169096965236971 3954 1409300
SGTC_631 k072-0230 41.5 µM -0.958027445397319 0.169122808921654 no 2821 0.169024459632235 4062 5773147
SGTC_2252 omeprazole 400 µM -0.959288440893229 0.168814215492388 no 2822 0.168706728445814 3988 4594 A proton pump inhibitor.
SGTC_506 n9-isopropylolomoucine 153 µM -0.96275045758491 0.167968845147736 no 2823 0.167836384220362 4056 6610355
SGTC_1403 3909-7815 62.9 µM -0.963362159707222 0.167819760792341 no 2824 0.16768290454125 3994 6615483
SGTC_2093 5331342 194.4 µM -0.963375439682558 0.167816525135074 no 2825 0.167679573519691 4129 33839
SGTC_1402 3909-7673 35.9 µM -0.967866268189409 0.16672464138994 no 2826 0.16655558133239 4044 5328014
SGTC_716 1683-5115 658 µM -0.969196974150908 0.166401980765828 no 2827 0.166223460256073 3993 723597
SGTC_1473 k844-0725 134 µM -0.96928628028977 0.166380340861254 no 2828 0.166201186323973 4105 54682906
SGTC_2088 5278280 127.392 µM -0.969739874982052 0.166270457705063 no 2829 0.166088084590099 4109 791502
SGTC_2384 9036245 200 µM -0.970656372453389 0.16604857956922 no 2830 0.165859711974632 4003 6462766
SGTC_1003 4049-0218 100 µM -0.971543795872296 0.165833922462559 no 2831 0.165638777534335 4096 295161
SGTC_3112 9123419 49.47 µM -0.972237681936157 0.165666204745001 no 2832 0.165466159124395 4096 17015854
SGTC_422 cantharidin 155 µM -0.972496617759978 0.165603646032229 no 2833 0.165401773346016 3992 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1907 st060210 83.7 µM -0.972779130297561 0.165535408631707 no 2834 0.165331543584104 4113 688793
SGTC_3159 9100096 49.47 µM -0.974342749448907 0.165158064744881 no 2835 0.164943192653277 4005 25236875
SGTC_2246 7293507 91.5585 µM -0.97478920042155 0.165050426228051 no 2836 0.164832417595661 4098 887656
SGTC_1654 st012436 41.8 µM -0.976145801831614 0.164723630847939 no 2837 0.164496108411392 3995 4323132
SGTC_2486 5283202 22.39 µM -0.97936837140397 0.163949019174171 no 2838 0.163698999507535 4113 1377751
SGTC_428 3448-4153 16.5 µM -0.979806832522392 0.16384380887878 no 2839 0.163590739407014 4038 3834874
SGTC_500 h-89 112 µM -0.98001252186292 0.163794468096824 no 2840 0.163539968832047 4101 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2443 5493264 126.67 µM -0.980128689852795 0.163766605968344 no 2841 0.163511299453528 4097 5340055
SGTC_2763 lisinopril 49.32 µM -0.980538818335571 0.163668263952754 no 2842 0.163410108959992 3944 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2556 citropten 84.59 µM -0.981110733907714 0.163531192095038 no 2843 0.163269068863126 4099 2775 A potential DNA crosslinker.
SGTC_1298 1079-1278 263 µM -0.983993096158783 0.162841507024647 no 2844 0.1625594537102 4074 2840950
SGTC_1877 wortmannin 25 µM -0.984708810250421 0.162670546161489 no 2845 0.162383561944113 4077 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1916 st067606 49.2 µM -0.985879351126647 0.162391193663685 no 2846 0.162096160367114 4030 19590279
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.986113675210922 0.162335309168005 no 2847 0.162038666859094 4082 688751
SGTC_1854 st056233 32.9 µM -0.989843148369849 0.161447543909033 no 2848 0.161125395511996 3980 5393174
SGTC_2533 agelasine 13.65 µM -0.991089962711223 0.161151459169026 no 2849 0.160820826860834 4142 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1160 4092-0570 10.5 µM -0.99184711625908 0.160971828656861 no 2850 0.160636054866079 4071 4994975
SGTC_2124 5246320 200 µM -0.991926450833579 0.16095301453275 no 2851 0.1606167024785 4091 579342
SGTC_2119 5528445 120.635 µM -0.992006124375153 0.160934121467474 no 2852 0.160597268938012 4106 791935
SGTC_2899 9053889 58.44 µM -0.997351752631273 0.159669814447642 no 2853 0.159296900761233 4055 6470052
SGTC_1961 st076550 68.7 µM -0.997949522731979 0.159528839581192 no 2854 0.15915191807901 4118 1579337
SGTC_512 prima-1 270 µM -0.999281558441822 0.159214992623299 no 2855 0.158829158203404 4094 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2444 5485484 36.41 µM -0.999330851184226 0.159203386302002 no 2856 0.158817222527639 4173 6790631
SGTC_285 1486-1325 46 µM -0.999371917307025 0.159193717419039 no 2857 0.158807279282989 4138 22310230
SGTC_2766 oltipraz 83.91 µM -0.999448450973063 0.159175698846547 no 2858 0.158788749453624 4049 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_598 3937-0236 20.2 µM -1.00099557023288 0.158811741934065 no 2859 0.15841447499674 4160 1379313
SGTC_1683 st010134 710 nM -1.00143048865872 0.158709526490522 no 2860 0.158309365126288 4078 3818134
SGTC_2010 4012422 159 µM -1.0022801654551 0.158509958132576 no 2861 0.158104149665309 4068 952393
SGTC_2705 st078069 42.8 µM -1.00294074690319 0.15835491742937 no 2862 0.157944725551644 4146 1530061
SGTC_2989 9073649 71.4286 µM -1.00402028342611 0.158101760771947 no 2863 0.157684418480358 4004 21367202
SGTC_2061 5245884 80.95 µM -1.00635652321522 0.157554810996974 no 2864 0.1571220498312 4058 573863
SGTC_3190 9110366 49.47 µM -1.00686724683184 0.157435408528285 no 2865 0.156999286753586 4094 17123768
SGTC_3031 9088762 49.47 µM -1.00849780851291 0.157054596402666 no 2866 0.156607769629455 4075 205253
SGTC_2488 5268135 45.7 µM -1.0138687548801 0.155804518241038 no 2867 0.155322691131373 4161 1270356 YLR208W SEC13
SGTC_1327 1436-0082 2.18 µM -1.02128448517041 0.154089331819594 no 2868 0.153559837428202 4102 15992205
SGTC_1714 st033236 13.627 µM -1.02260385790007 0.153785487592845 no 2869 0.153247592401065 4162 2916566
SGTC_1094 duloxetine 25.4 µM -1.0240797585851 0.153446066116975 no 2870 0.152898802074155 4116 60834 A selective serotonin reuptake inhibitor.
SGTC_3095 9117207 49.47 µM -1.02930846964151 0.152247584624402 no 2871 0.1516673722878 4093 17015229
SGTC_110 0850-0284 111.64 µM -1.03100505778563 0.151860045841771 no 2872 0.151269223993533 3922 3906265
SGTC_1849 st056239 19.2 µM -1.03479965612556 0.150995648648131 no 2873 0.150381241780546 4127 5393181
SGTC_2477 5967686 25.23 µM -1.03615795372495 0.150687030247406 no 2874 0.15006422943309 4118 776118
SGTC_671 0560-0003 407 µM -1.03634156623305 0.150645343953608 no 2875 0.150021410417769 4028 3238678
SGTC_2182 6325192 200 µM -1.03653244442898 0.15060201624366 no 2876 0.149976905658163 4077 736248
SGTC_2220 6782180 200 µM -1.03708510714065 0.15047661336559 no 2877 0.14984809763031 4040 833803
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.03737160947407 0.150411631448732 no 2878 0.14978135213466 4201 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1671 st016596 74.5 µM -1.03849463251145 0.150157097624118 no 2879 0.149519916436352 4181 2829167
SGTC_670 4204-0025 119 µM -1.04695323249408 0.148249180100851 no 2880 0.147560574244527 4144 719039
SGTC_2307 7538926 6.34 µM -1.04945914186488 0.147687076272562 no 2881 0.146983425307022 4123 96582
SGTC_723 4182-0001 115 µM -1.05324109292237 0.146841447850004 no 2882 0.146115254651458 4167 744821 YLR208W SEC13
SGTC_2744 captopril 92.04 µM -1.05336750100779 0.14681323973875 no 2883 0.146086296493979 4179 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_731 3966-0296 387 µM -1.05606279855652 0.146212646028743 no 2884 0.145469762561151 4145 660956
SGTC_2685 mycophenolic acid 18.85 µM -1.06129575354782 0.145051303412628 no 2885 0.144277757486044 4127 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1138 3761-0006 1.03 µM -1.06223710894345 0.144843050417485 no 2886 0.144064028617741 4190 12061087
SGTC_2275 7947463 200 µM -1.06278493624418 0.144721949083355 no 2887 0.143939746176865 4133 1225414
SGTC_697 0508-1955 564 µM -1.0638646270802 0.144483475018113 no 2888 0.14369501467626 4151 6243113
SGTC_345 1362-0200 395 µM -1.06431245172382 0.144384640579846 no 2889 0.143593589535861 4151 1419823
SGTC_72 0744-0168 198.391 µM -1.06562873112265 0.144094402903022 no 2890 0.14329575303096 4046 677577
SGTC_1411 3909-8223 150 µM -1.06697587284367 0.143797767750973 no 2891 0.142991365530959 4184 X1411
SGTC_1085 doxorubicin 7.67 µM -1.06732375223275 0.143721233099894 no 2892 0.142912833000249 4186 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2223 6903751 107.57 µM -1.06954104754237 0.143234066564761 no 2893 0.142412971529104 4145 5598863
SGTC_3021 9087658 49.47 µM -1.06969955184113 0.143199284022578 no 2894 0.142377284068316 4174 25237042
SGTC_2491 paeonol 100 µM -1.07257959202985 0.142568275070147 no 2895 0.141729892670656 4085 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2536 dehydroabietamide 32.04 µM -1.07297299412467 0.142482227934675 no 2896 0.141641616587576 4260 3983547
SGTC_3327 9140648 26.9345 µM -1.07381520978829 0.14229813186834 no 2897 0.141452755806372 4187 8029710
SGTC_1188 1403-0014 4.57 µM -1.07421313171918 0.14221120794166 no 2898 0.141363584074614 4154 9614867
SGTC_1631 benzylvanillin 81.9 µM -1.07467019264654 0.142111409763751 no 2899 0.141261206700967 4242 75506
SGTC_161 4065-0411 162.148 µM -1.07738029799437 0.141520638566366 no 2900 0.140655201155075 4171 1906281 YLR208W SEC13
SGTC_2029 5175081 200 µM -1.07792494549507 0.141402112904182 no 2901 0.140533625994153 4127 1380876
SGTC_527 4476-4215 268 µM -1.08220684682116 0.140472633469433 no 2902 0.139580313410984 4157 4418754
SGTC_42 0133-0086 60.653 µM -1.08272836410925 0.140359710868572 no 2903 0.139464505157653 4055 162923 Model of phenazepam hydroxylation.
SGTC_2167 5876490 200 µM -1.08326749324675 0.140243039642446 no 2904 0.139344854735624 4290 686534
SGTC_2248 tofa 1.1 µM -1.08615350412956 0.139619607431101 no 2905 0.138705542091712 4141 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_515 4092-1064 102 µM -1.08698001861784 0.139441412544604 no 2906 0.138522820204424 4212 717353
SGTC_2610 ononetin 44.17 µM -1.08704913963637 0.139426517202904 no 2907 0.138507546694058 4172 259632
SGTC_2432 5630864 12.22 µM -1.08770403322236 0.139285443596802 no 2908 0.138362893327063 4222 5714970
SGTC_2215 7188065 200 µM -1.0880607819378 0.139208635611531 no 2909 0.138284137752992 4201 940217
SGTC_193 1273-0060 1.558 µM -1.08813887028879 0.139191827038277 no 2910 0.138266903105589 3997 2847393 YHR072W ERG7
SGTC_507 nimesulide 162 µM -1.0881403733618 0.139191503514287 no 2911 0.138266571381184 4252 4495 A COX2 inhibitor.
SGTC_702 1488-0190 94 µM -1.09128153605306 0.138516512167136 no 2912 0.137574509859615 4218 949357
SGTC_735 3076-0345 636 µM -1.0917988289651 0.138405567512429 no 2913 0.137460766945888 4244 2888990
SGTC_3283 9109332 35.8195 µM -1.09640079775878 0.137421241788197 no 2914 0.136451707504889 4031 17027281
SGTC_1000 4048-0884 8.67 µM -1.10510655340889 0.135572247973162 no 2915 0.13455671064036 4243 13040088
SGTC_1006 4099-6547 255 µM -1.10826070030457 0.134906572374713 no 2916 0.133874621348449 4223 3146833
SGTC_2676 harmalol 100 µM -1.10886594430762 0.134779093830612 no 2917 0.133744008598496 4154 5459187 A monoamine oxidase inhibitor
SGTC_1436 4092-1007 8.32 µM -1.10995154271882 0.134550648546749 no 2918 0.13350995404026 4200 2881121
SGTC_2754 granisetron 64.02 µM -1.11154669882366 0.134215458163461 no 2919 0.13316655039324 4215 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1293 1000-1278 195 µM -1.11322421622573 0.133863580392754 no 2920 0.132806072355148 4246 678847
SGTC_192 3455-0609 60.9 µM -1.11331760607647 0.133844009491204 no 2921 0.132786023780108 4266 3769639
SGTC_2916 7875993 68.79 µM -1.11547591118664 0.13339226006467 no 2922 0.132323267756957 4041 1299250
SGTC_2651 TUB2.036 5 µM -1.11635747220898 0.133208044782162 no 2923 0.132134574886667 4160 15992207 YFL037W TUB2
SGTC_3116 9124943 49.47 µM -1.11976342416266 0.132497965665646 no 2924 0.131407294732705 4198 41905195 YPL160W CDC60
SGTC_826 1683-5028 118 µM -1.12090668366175 0.132260202542745 no 2925 0.13116379281075 4255 722377
SGTC_1313 1220-0047 237 µM -1.12107134708792 0.132225981816062 no 2926 0.131128746973864 4179 3528706
SGTC_820 1582-0060 59.9 µM -1.12165280330214 0.132105191101728 no 2927 0.1310050455624 4226 3848840
SGTC_2840 9008771 71.43 µM -1.12294839564956 0.13183632068115 no 2928 0.130729705906518 4161 2992978
SGTC_1891 st059073 26.2 µM -1.1239231000774 0.131634292179365 no 2929 0.130522825307296 4293 688754
SGTC_1059 3448-6867 171 µM -1.12622824357357 0.131157351974612 no 2930 0.130034460784587 4178 3934407
SGTC_2398 5228213 48.84 µM -1.12731961711472 0.13093196078683 no 2931 0.129803685591503 4218 80771 YMR134W ERG29
SGTC_1296 1068-0102 11.9 µM -1.12887073666221 0.130612083301494 no 2932 0.12947618352403 4217 767053
SGTC_2515 chrysin 20.77 µM -1.13029523604139 0.130318794223788 no 2933 0.129175920647303 4245 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3069 9117009 49.47 µM -1.13083655154334 0.130207462743922 no 2934 0.129061946215382 4211 41904981
SGTC_2764 methyldopa 94.69 µM -1.1310016922546 0.130173511626881 no 2935 0.129027189585458 4222 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3244 9134489 49.47 µM -1.13130401615027 0.130111373027022 no 2936 0.128963577274321 4231 16584271
SGTC_1759 st043059 70 µM -1.13172835572451 0.130024190381482 no 2937 0.128874328200191 4219 669426
SGTC_694 1315-0438 43.2 µM -1.13554070618269 0.129242737689788 no 2938 0.128074418208749 4229 6793154
SGTC_3341 9147222 25.867 µM -1.13689142203754 0.128966651610515 no 2939 0.127791839250293 4234 1939759
SGTC_1521 st012942 49.4 µM -1.13758033552511 0.128825995431931 no 2940 0.127647880838422 4198 24207259
SGTC_1141 3253-0389 52.6 µM -1.13773797663012 0.128793824651472 no 2941 0.127614955311494 4230 5402031
SGTC_3293 9120939 62.045 µM -1.14077786770551 0.128174545352547 no 2942 0.126981186499435 4231 934087
SGTC_967 1306-0166 352 µM -1.14392423971931 0.127535755146666 no 2943 0.126327528711785 4245 4437607
SGTC_2413 inermin 26.06 µM -1.14520628156115 0.127276105212644 no 2944 0.12606185844402 4306 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2151 5563267 85.4165 µM -1.14655493791682 0.127003361078534 no 2945 0.125782804701626 4287 5310824
SGTC_111 0083-0039 52.457 µM -1.15088813442609 0.126129795783312 no 2946 0.124889129941968 4131 759313
SGTC_2614 arthonioic acid 13.39 µM -1.15245001086785 0.125815953423118 no 2947 0.124568100159788 4103 6710684
SGTC_1926 methyl fluorone black 53.6 µM -1.15380483754797 0.125544156998905 no 2948 0.124290095221386 3916 72721 Reacts with homocysteine.
SGTC_687 k029-0044 34.9 µM -1.1557271750901 0.125159213828556 no 2949 0.123896384492961 4311 5829338
SGTC_632 0781-2353 4.65 µM -1.15646138671823 0.125012407576777 no 2950 0.123746242451372 4314 6811515 YHR007C ERG11
SGTC_2219 9098279 200 µM -1.15661143177563 0.124982420745624 no 2951 0.123715574785649 4183 902349
SGTC_2933 9026794 32.47 µM -1.15846030831141 0.124613331127688 no 2952 0.123338120174673 4193 17586027
SGTC_2983 9022671 12.99 µM -1.16044567723229 0.124217842748551 no 2953 0.122933699369708 4247 6405161
SGTC_878 0828-0289 13.7 µM -1.16157633606557 0.12399300666059 no 2954 0.122703799472041 4192 745350 YLR208W SEC13
SGTC_2066 5222451 176 µM -1.16310180815644 0.123690111902805 no 2955 0.122394099297525 4210 2281147
SGTC_2237 6667747 47.222 µM -1.16338930574186 0.123633085014025 no 2956 0.122335793250136 4261 729940 YDL015C TSC13
SGTC_793 0488-0545 106 µM -1.16391106460366 0.123529638012428 no 2957 0.122230027565536 4285 292548
SGTC_559 1550-0661 158 µM -1.16478223172338 0.123357050403011 no 2958 0.122053576471734 4311 5830875
SGTC_796 1234-0020 70.7 µM -1.16596659173334 0.123122686959751 no 2959 0.121813976545189 4192 46495034
SGTC_211 3455-0679 143.504 µM -1.16668061436467 0.122981545665731 no 2960 0.121669687180641 4288 748649
SGTC_1522 st012842 45.6 µM -1.16737804005944 0.12284379464395 no 2961 0.121528867709141 4106 3491067 YOR116C RPO31
SGTC_2435 5706476 10.6 µM -1.16973853076184 0.122378368728845 no 2962 0.121053103620341 4249 5725375
SGTC_1490 4089-0339 670 nM -1.17000311089635 0.122326277809062 no 2963 0.120999858467682 4230 742542
SGTC_329 k048-0121 21.3 µM -1.17008376272074 0.122310402056737 no 2964 0.120983631053097 4270 6832902
SGTC_3305 9127027 53.8275 µM -1.17241442631635 0.12185225173988 no 2965 0.120515355158196 4197 41905295
SGTC_293 4049-0273 38.5 µM -1.17350369731518 0.121638542146558 no 2966 0.120296937531685 4140 1380311
SGTC_317 4495-0002 170 µM -1.17387608531564 0.121565541913571 no 2967 0.120222331316949 4281 15991618
SGTC_1106 tegaserod maleate 11.7 µM -1.1741614220938 0.121509627409309 no 2968 0.120165187476174 4274 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_356 1634-0012 32.5 µM -1.17506557096984 0.12133257009371 no 2969 0.119984241759334 4274 735457
SGTC_2955 9076254 12.21 µM -1.17571161160357 0.121206168674004 no 2970 0.119855068486223 4173 16459619
SGTC_2671 danthron 100 µM -1.1768716902993 0.1209794253963 no 2971 0.119623361499026 4258 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1611 st001856 99.4 µM -1.17782508839704 0.120793302451598 no 2972 0.119433172289929 4232 647478
SGTC_523 1934-0222 13.7 µM -1.18324673198778 0.119738717722974 no 2973 0.118355688556477 4215 1361595
SGTC_2262 9014885 67.46 µM -1.1849033509279 0.119417781291757 no 2974 0.118027831181281 4262 6457424
SGTC_49 0717-0965 32.132 µM -1.18553257665779 0.119296040718556 no 2975 0.117903471163772 4351 5889349 YGL099W LSG1
SGTC_117 lucigenin 22.078 µM -1.18839086287309 0.118744131367248 no 2976 0.117339727279379 4264 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1 0258-0098 57.368 µM -1.18920037878657 0.118588149420035 no 2977 0.117180412753992 4226 6790032 YDR047W HEM12
SGTC_56 0957-0365 83.25 µM -1.19052126325741 0.11833394515798 no 2978 0.11692078887739 4247 6752360
SGTC_2199 6590217 200 µM -1.19147682199049 0.118150288151603 no 2979 0.116733225208879 4170 703109
SGTC_465 cgp-37157 41 µM -1.1918022470624 0.118087787961754 no 2980 0.116669397250091 4263 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1276 0871-0068 94.2 µM -1.1941007067751 0.117647018281371 no 2981 0.116219288403766 4287 3414906
SGTC_2193 5925765 200 µM -1.19508396803095 0.117458816892779 no 2982 0.116027112538725 4284 877370
SGTC_183 3914-0051 30.55 µM -1.19790546302527 0.116919951704418 no 2983 0.115476911370861 4312 1596232
SGTC_2708 st078559 56 µM -1.19953405244204 0.116609713143662 no 2984 0.115160176036764 4222 17250902
SGTC_1404 3909-7820 48.3 µM -1.20555898470837 0.115467067989045 no 2985 0.113993790929483 4263 23741373
SGTC_1557 sumaresinolic acid 42.3 µM -1.20574359710752 0.115432181807753 no 2986 0.113958184634866 4267 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_80 0159-0065 512.242 µM -1.20739907705871 0.115119680683211 no 2987 0.113639245409164 4222 1548079
SGTC_861 0443-0273 110 µM -1.20916131014313 0.11478768949721 no 2988 0.11330043926593 4288 6149169
SGTC_1429 4049-0205 9.46 µM -1.21316760358151 0.114035470519902 no 2989 0.112532873724717 4323 22774478
SGTC_3064 1327-0027 10 µM -1.21470589681524 0.113747576714228 no 2990 0.112239141342633 4234 16000455 YPR107C YTH1
SGTC_1874 staurosporine 7.6 µM -1.21520162385486 0.113654911147543 no 2991 0.112144600626176 4307 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1496 4469-0713 57.4 µM -1.21697251925786 0.113324319674269 no 2992 0.111807335879081 4282 746691
SGTC_2860 9025725 38.96 µM -1.21746792878419 0.113231959326326 no 2993 0.111713115765262 4338 40546248
SGTC_2207 7258803 200 µM -1.21887947785488 0.112969095481419 no 2994 0.111444969946271 4298 3666799
SGTC_2808 7946468 45.46 µM -1.22521317703166 0.111794972832769 no 2995 0.1102474554785 4283 2970879
SGTC_2366 9070441 60.58 µM -1.22583410095881 0.11168033927928 no 2996 0.110130555819218 4284 6837235
SGTC_2518 prenyletin 46.28 µM -1.22692372177844 0.111479379281718 no 2997 0.10992563084814 4305 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3336 9143619 71.43 µM -1.22749438655582 0.111374234249369 no 2998 0.1098184151796 4336 45595730
SGTC_1606 st000094 49.2 µM -1.23035058768438 0.11084904564692 no 2999 0.10928292414657 4335 1242210
SGTC_305 1682-2595 20.8 µM -1.23066663893418 0.110791040423302 no 3000 0.10922378517476 4322 226033
SGTC_2791 5663188 71.43 µM -1.23329027170689 0.110310361788641 no 3001 0.108733743053603 4344 54690634
SGTC_3081 9117243 49.47 µM -1.23400829192019 0.110179073555564 no 3002 0.108599907220386 4288 45595589
SGTC_2387 9077560 195.08 µM -1.2359134010371 0.109831272333834 no 3003 0.108245377576138 4325 5303272
SGTC_1246 0422-0085 105 µM -1.23843619637588 0.109371918481584 no 3004 0.107777183129742 4350 264295
SGTC_3039 9090270 49.47 µM -1.23890757269944 0.109286242905331 no 3005 0.107689864467062 4322 17173750
SGTC_1634 st006576 41 µM -1.2389363602851 0.109281012145376 no 3006 0.107684533450801 4295 3915356
SGTC_1908 st060353 56.5 µM -1.24108261009266 0.108891540853936 no 3007 0.107287616474603 4372 4227716
SGTC_3125 9127534 49.47 µM -1.2417892621897 0.108763526179406 no 3008 0.107157162778108 4213 1639235
SGTC_940 3232-1287 54.8 µM -1.2434075815354 0.108470764774952 no 3009 0.1068588389536 4318 1585493 YIL048W NEO1
SGTC_3287 9117173 37.0625 µM -1.24506629747066 0.108171284242057 no 3010 0.106553690681088 4321 2789709
SGTC_2986 9022445 71.43 µM -1.24747301586977 0.107737811173514 no 3011 0.106112054240855 4319 6459286
SGTC_1333 1482-0047 286 µM -1.24873590755591 0.10751085349934 no 3012 0.105880841442917 4330 3811116
SGTC_2785 7756463 72.73 µM -1.25007562476966 0.107270466154085 no 3013 0.105635961524705 4294 2201551
SGTC_1258 0671-0043 57.1 µM -1.25192594465393 0.106939098210233 no 3014 0.105298424948203 4336 4298767
SGTC_1368 1852-0141 284 µM -1.25227542185319 0.106876594439154 no 3015 0.105234760790515 4331 2838987
SGTC_863 0466-0191 129 µM -1.25270851635112 0.106799172344946 no 3016 0.105155902744588 4376 765160 YPR165W RHO1
SGTC_3339 9145883 14.936 µM -1.255142498465 0.106364814535356 no 3017 0.10471351756745 4237 2030670
SGTC_2650 prasterone 100 µM -1.2593655081334 0.105614224089558 no 3018 0.103949170908547 4325 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1031 k035-0009 16 µM -1.26439029322705 0.104726126393566 no 3019 0.10304498758044 4376 5180959
SGTC_3164 9100705 49.47 µM -1.26465386863753 0.104679690915842 no 3020 0.102997716772497 4337 17174235
SGTC_941 3237-0776 460 µM -1.26587301959445 0.104465100633559 no 3021 0.102779273650155 4377 760008
SGTC_85 0868-0259 160.055 µM -1.26633164003713 0.104384458577599 no 3022 0.102697186879789 4257 83173
SGTC_588 3970-1144 52.9 µM -1.26723722777738 0.104225356010075 no 3023 0.102535239048203 4222 1888707
SGTC_652 0437-0092 114 µM -1.26867122595864 0.103973776770897 no 3024 0.102279174562251 4283 3091274
SGTC_3118 9124250 49.47 µM -1.26872455559849 0.103964429171477 no 3025 0.102269660636734 4299 1504786
SGTC_1636 st007707 68.9 µM -1.27103911917691 0.103559320345049 no 3026 0.101857366057179 4355 403051
SGTC_1433 4060-0023 7.6 µM -1.27151824571486 0.103475604043773 no 3027 0.101772170314666 4364 3840627
SGTC_2296 7971656 126.45 µM -1.27265750141023 0.103276742688441 no 3028 0.101569802248207 4354 666570
SGTC_1607 st000305 50.6 µM -1.27349979491987 0.103129895713042 no 3029 0.101420372644651 4344 5457690
SGTC_728 3030-5151 22.5 µM -1.27600946446515 0.102693254520862 no 3030 0.100976086726025 4430 3125388
SGTC_2324 6149169 200 µM -1.27616665173888 0.102665951303593 no 3031 0.100948307207034 4259 2888231
SGTC_836 0330-0104 1.35 µM -1.28384929546149 0.101337910356167 no 3032 0.0995973457177274 4377 46494820
SGTC_233 rapamycin 362 pM -1.2848009772197 0.101174275468514 no 3033 0.0994309204019831 4336 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_368 fentichlor 4.58 µM -1.28558443152092 0.101039710664441 no 3034 0.099294066482826 4364 7329 A pesticide.
SGTC_3252 9135871 49.47 µM -1.28591241185103 0.100983416065044 no 3035 0.0992368157407028 4371 17682838
SGTC_426 0988-0037 14.6 µM -1.28701825231081 0.100793777933273 no 3036 0.0990439631927284 4386 5383008
SGTC_1001 4048-4355 44.4 µM -1.29363604191101 0.0996643330670021 no 3037 0.0978955834565603 4355 21824233
SGTC_381 3461-2219 42.7 µM -1.29508133630194 0.0994189026598025 no 3038 0.0976460862726773 4352 2883159
SGTC_1346 1488-2224 62.4 µM -1.29549777828671 0.0993482672716862 no 3039 0.0975742836421175 4379 3722427
SGTC_2829 7992743 58.44 µM -1.30061457158821 0.0984833683183138 no 3040 0.0966952083849002 4359 16462845
SGTC_339 3091-4833 71.4 µM -1.30651781975957 0.0974923979740462 no 3041 0.0956882615610349 4211 3240077
SGTC_1154 4088-0362 150 µM -1.3070139161877 0.0974094532658591 no 3042 0.0956039926273145 4373 6618304
SGTC_3059 1327-0034 3 µM -1.30893382815807 0.0970889419073659 no 3043 0.0952783832720733 4217 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3073 9114972 49.47 µM -1.31148191579652 0.0966647587522523 no 3044 0.0948474997781368 4373 41905075
SGTC_2175 5807670 165.306 µM -1.31468902841056 0.0961328038015457 no 3045 0.0943072177039481 4328 241186
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.31521575473879 0.0960456433093831 no 3046 0.0942187008749992 4406 688788
SGTC_3060 1327-0027 12.5 µM -1.31607493736475 0.0959035940431874 no 3047 0.0940744460067738 4298 16000455 YPR107C YTH1
SGTC_2601 securinine 100 µM -1.31661880934515 0.0958137552047087 no 3048 0.0939832153655162 4353 442872 A GABA receptor antagonist.
SGTC_360 0957-0399 1.01 µM -1.31726891765476 0.0957064490896752 no 3049 0.0938742500212565 4388 6752301 YPR165W RHO1
SGTC_825 1988-2224 89.6 µM -1.3196753707055 0.0953100121556585 no 3050 0.0934717132593295 4357 1180859
SGTC_321 4534-3890 65.3 µM -1.32125277586332 0.0950508086228548 no 3051 0.0932085471755177 4371 699746
SGTC_2748 diazoxide 86.69 µM -1.32704444935117 0.0941035578991201 no 3052 0.0922469897337 4462 3019 A potassium channel activatior.
SGTC_1730 st033808 45.1 µM -1.32939549717858 0.0937210287879186 no 3053 0.0918587613105456 4308 1045166
SGTC_12 0849-0099 9.267 µM -1.33221426205638 0.093263914180388 no 3054 0.0913948956481342 4312 6071388
SGTC_2655 perillic acid 100 µM -1.33566287881491 0.0927069006863555 no 3055 0.0908297438930009 4427 5702197 An apoptosis inducer.
SGTC_2077 5212015 200 µM -1.3368423604568 0.0925169589999282 no 3056 0.0906370493387082 4303 780900
SGTC_1010 4112-3296 15.2 µM -1.33984805172687 0.0920342296028407 no 3057 0.0901473749390454 4426 704384
SGTC_784 4579-0127 173 µM -1.340717160132 0.0918949945607976 no 3058 0.090006150467052 4427 1948547
SGTC_2532 xanthone 78.9 µM -1.34179151618953 0.0917230936287814 no 3059 0.0898318018832719 4417 7020 An insecticide.
SGTC_3195 9113082 49.47 µM -1.34377997983952 0.091405560810039 no 3060 0.089509772626508 4396 17018038
SGTC_2329 6138490 200 µM -1.34415066475033 0.0913464572740493 no 3061 0.0894498357181037 4442 720019
SGTC_2859 9028643 45.46 µM -1.34512196624584 0.0911917233307266 no 3062 0.0892929253076874 4220 17151580
SGTC_38 0929-0051 58.268 µM -1.34702927468241 0.090888443775211 no 3063 0.0889854022300868 4365 1379719
SGTC_10 0279-0212 42.575 µM -1.34771277864731 0.0907799427034695 no 3064 0.0888753902138934 4397 39851 YBR002C RER2
SGTC_2600 tangeritin 87.95 µM -1.34783967042193 0.0907598101791907 no 3065 0.0888549777508788 4302 68077 A bioactive flavone.
SGTC_641 4092-0595 30 µM -1.34983650184864 0.0904434310578794 no 3066 0.0885342167089626 4451 786260
SGTC_994 3910-0338 138 µM -1.35680833850167 0.0893452295553612 no 3067 0.0874210586624466 4472 3479481
SGTC_3189 9110682 49.47 µM -1.36080419430085 0.0887202922979197 no 3068 0.0867877880441236 4427 17122418
SGTC_532 1548-0774 215 µM -1.36138768859022 0.0886293089808339 no 3069 0.0866956023402619 4495 5932993
SGTC_2522 biochanin a 4.94 µM -1.36183602955357 0.0885594471312119 no 3070 0.0866248191130819 4416 5280373 A possible chelator.
SGTC_3090 9117696 49.47 µM -1.36485902161091 0.0880894658031478 no 3071 0.0861486819724151 4363 7923821
SGTC_2759 disulfiram 3.38 µM -1.36741544375104 0.0876934748603808 no 3072 0.0857475621499359 4326 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_979 1426-2828 121 µM -1.3678196851593 0.0876309794806546 no 3073 0.0856842621824097 4485 747872
SGTC_1698 5-fluorocytosine 1.055 µM -1.37041781227814 0.0872301041800137 no 3074 0.0852782574708994 4430 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_854 0422-0053 192 µM -1.37602608290977 0.0863694523290181 no 3075 0.0844067790928699 4442 3596728
SGTC_3326 9140064 16.379 µM -1.38116873650299 0.0855858499887441 no 3076 0.0836135424922163 4370 1868434
SGTC_2659 sanguinarine 24.21 µM -1.38412875177189 0.0851372435910288 no 3077 0.0831595172797694 4377 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2035 5154463 94.595 µM -1.3858147267902 0.0848825138244722 no 3078 0.0829017421699191 4433 2769623
SGTC_2063 5246145 200 µM -1.38879050123877 0.084434306418877 no 3079 0.082448232251805 4472 711240
SGTC_1571 st070080 73.4 µM -1.38942763922818 0.0843385727118757 no 3080 0.0823513752450207 4415 4315245
SGTC_648 0375-0473 33.3 µM -1.39192152461601 0.0839646351626058 no 3081 0.0819730815055255 4405 1713139
SGTC_2257 7960413 200 µM -1.39571196253361 0.0833986763167363 no 3082 0.0814006252569777 4464 2974689 YIL048W NEO1
SGTC_199 4063-0024 41.6 µM -1.3962316626501 0.0833213027717693 no 3083 0.0813223724443541 4462 306215
SGTC_1716 st033144 30.6155 µM -1.3977696228289 0.0830926456530037 no 3084 0.0810911296027106 4425 674617
SGTC_270 tamoxifen 5.46 µM -1.3978864722046 0.0830752923125377 no 3085 0.081073580802906 4450 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_417 st075190 100 µM -1.40306380245039 0.0823091381835254 no 3086 0.0802989070000896 4426 222757
SGTC_2348 9022543 33.42 µM -1.40481600853217 0.0820510511976737 no 3087 0.0800379987396243 4440 3162678 YDL140C RPO21
SGTC_2298 7976326 193.81 µM -1.40532153559932 0.0819767042469723 no 3088 0.0799628436430652 4376 2235818
SGTC_2346 9031566 143.75 µM -1.40593943274973 0.0818859001846411 no 3089 0.0798710553306647 4400 4771086
SGTC_600 1495-0418 41.6 µM -1.40908576356967 0.0814247014708161 no 3090 0.079404904968204 4425 5377768
SGTC_135 0933-0004 26.348 µM -1.40951225991156 0.0813623354272882 no 3091 0.0793418754340982 4381 21230617 YGL099W LSG1
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.41023359908357 0.0812569368900972 no 3092 0.0792353589136078 4394 279621
SGTC_2965 9082772 38.63 µM -1.41354092730024 0.080775004873553 no 3093 0.0787483681998168 4445 16459634
SGTC_113 0099-0221 2.5 µM -1.41665166532949 0.0803236918603699 no 3094 0.0782923975730131 4411 89219
SGTC_73 0327-0325 16.231 µM -1.41838144861927 0.0800735567116863 no 3095 0.0780397144029754 4260 53298
SGTC_3024 9090631 49.47 µM -1.41981077444889 0.0798673138867808 no 3096 0.0778313886800425 4407 25236383
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.42014376900782 0.0798193225938953 no 3097 0.0777829150521306 4391 6708514
SGTC_2380 9035439 200 µM -1.4245098894777 0.0791920920280821 no 3098 0.0771494621799405 4503 6462575
SGTC_2915 7971052 15.16 µM -1.42820324405103 0.0786644297218843 no 3099 0.0766166835819353 4379 5741558
SGTC_3240 9133527 49.47 µM -1.43207518314766 0.0781141187702259 no 3100 0.0760611529482464 4426 17617455
SGTC_2496 diffractaic acid 79.83 µM -1.43593082710181 0.077569030702305 no 3101 0.0755110127631759 4444 94870 An apoptosis inducer which activates caspases.
SGTC_145 3737-0113 38.366 µM -1.44107175120236 0.0768467363019572 no 3102 0.0747822066067575 4439 6849351
SGTC_1797 st048695 56.8 µM -1.44481145607176 0.0763245326567575 no 3103 0.0742554261680083 4417 592262 YIL048W NEO1
SGTC_473 2-arachidonoylglycerol 10 µM -1.44709953820755 0.0760063643168296 no 3104 0.0739345236787342 4302 5282280 An endocannabinoid.
SGTC_855 0428-0020 25 µM -1.44789830184976 0.0758955306770934 no 3105 0.0738227473265789 4480 6812414
SGTC_2605 digitonin 300 nM -1.45107316049799 0.0754562149576943 no 3106 0.0733797446212512 4464 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_490 phenamil 164 µM -1.45759123312218 0.0745603646949895 no 3107 0.0724766237742427 4482 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.45814929213254 0.0744840434189686 no 3108 0.0723996985881613 4384 5355888
SGTC_1271 0832-2808 169 µM -1.46358630549475 0.0737435845607177 no 3109 0.0716535082775691 4512 3663794
SGTC_1399 3562-5772 25 µM -1.46653522044654 0.0733443366116582 no 3110 0.0712512666662329 4472 23847490
SGTC_1923 st058458 19.1 µM -1.46735256405561 0.0732339711914135 no 3111 0.0711400857347176 4470 3534982
SGTC_3119 9125183 49.47 µM -1.46818934088718 0.0731211133834031 no 3112 0.0710263994095884 4334 22695334
SGTC_1043 0916-0009 19.3 µM -1.4683703760635 0.0730967143179684 no 3113 0.0710018219448973 4491 3101130
SGTC_889 0919-1524 82.7 µM -1.47394807880132 0.0723480270708876 no 3114 0.0702477856414103 4491 3905452
SGTC_394 menadione 8.33 µM -1.47505314361811 0.0722003956069115 no 3115 0.0700991281758971 4496 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_112 phenothiazine 287.218 µM -1.47627820050961 0.0720370037466675 no 3116 0.0699346118984233 4443 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2820 7989630 71.43 µM -1.4786749735242 0.0717181543914296 no 3117 0.0696136020665106 4511 2984098
SGTC_1275 0867-0008 21.1 µM -1.47973613444207 0.0715773314472696 no 3118 0.0694718391896667 4460 3422836
SGTC_2025 5147754 141 µM -1.48150279524581 0.0713433548509134 no 3119 0.069236320301627 4457 315777 YLR208W SEC13
SGTC_2827 7993847 71.43 µM -1.48152753084947 0.0713400830395307 no 3120 0.0692330270957297 4519 2985692
SGTC_2743 auranofin 4.32 µM -1.48157325406157 0.0713340354723234 no 3121 0.0692269399957368 4535 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1662 st014054 52 µM -1.48414574180649 0.0709944196397123 no 3122 0.0688851302251763 4564 2838777
SGTC_154 3389-1638 511.116 µM -1.48416698857153 0.0709916198546781 no 3123 0.0688823125671332 4472 5238686
SGTC_3111 9122088 49.47 µM -1.48502677128224 0.0708783934256864 no 3124 0.0687683662709479 4415 16876704
SGTC_2073 5212005 126 µM -1.4864855853976 0.0706865968613632 no 3125 0.0685753634127679 4388 691789
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.48711827422919 0.0706035386423011 no 3126 0.0684917879289128 4410 4000243
SGTC_1245 0418-0076 17.2 µM -1.48932815526045 0.0703140180300154 no 3127 0.0682004885573568 4503 6790114
SGTC_822 1487-0950 154 µM -1.48972469940088 0.0702621627915461 no 3128 0.0681483187280073 4486 1958375
SGTC_344 k064-0035 6.43 µM -1.49011275574218 0.0702114459619792 no 3129 0.06809729539155 4443 5088750
SGTC_1791 st048313 56.1 µM -1.49357628055238 0.0697600286627496 no 3130 0.0676432014360833 4506 1204976
SGTC_382 3229-0966 23.2 µM -1.49463474251898 0.0696225210071813 no 3131 0.0675048968991644 4531 5722370
SGTC_1087 pterostilbene 9.05 µM -1.49811467185047 0.0691719046005744 no 3132 0.0670517298926216 4499 5281727 Similar to reservatol, lowers cholesterol.
SGTC_763 3453-1109 128 µM -1.50218231480534 0.0686480374536995 no 3133 0.0665250154421661 4528 1560353
SGTC_459 nigericin 15.3 µM -1.50502072285708 0.0682842983355367 no 3134 0.0661593745235436 4523 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_450 aminopyrene 156 nM -1.50671283441358 0.0680681646562815 no 3135 0.0659421401766859 4458 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1861 st057647 17.4 µM -1.50698119022925 0.0680339360994495 no 3136 0.0659077393264012 4534 688668
SGTC_1893 st059353 36.1 µM -1.50794564576 0.0679110303068196 no 3137 0.0657842194280806 4495 3112488
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.50807261947376 0.0678948621392993 no 3138 0.0657679710063076 4482 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3219 9131112 49.47 µM -1.50820151759992 0.0678784519678687 no 3139 0.065751479505732 4365 17612988 YMR079W SEC14
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.51255719960382 0.0673257236400163 no 3140 0.0651960864588364 4480 689007
SGTC_1468 k284-1086 134 µM -1.51358241911838 0.0671961323269181 no 3141 0.0650658914455727 4509 15996457
SGTC_1475 4092-1048 11.7 µM -1.51659819996922 0.0668160451361564 no 3142 0.0646840800724585 4506 2881759
SGTC_892 0929-0076 29 µM -1.52240578321493 0.0660887878396349 no 3143 0.0639537183265796 4488 5751038
SGTC_657 3534-0529 86.7 µM -1.52424216567988 0.0658601066413069 no 3144 0.0637241142199032 4539 1049549
SGTC_273 hydroxyurea 18.1 mM -1.52677042108907 0.0655462717788951 no 3145 0.0634090546042472 4567 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1039 k821-0043 94 µM -1.52692213770571 0.0655274759903904 no 3146 0.0633901870053992 4491 15992768
SGTC_1813 st051246 8.6015 µM -1.53983401284121 0.0639431178052098 no 3147 0.0618004094036435 4467 5291959
SGTC_253 dyclonine 31.25 µM -1.54083124738886 0.063822001738547 no 3148 0.0616789311561629 4607 3180 An oral anasthetic.
SGTC_1539 benzyladenosine 56 µM -1.54475799427091 0.063346824664772 no 3149 0.0612024056121644 4530 92208 A nucleotide analog.
SGTC_2845 9003024 42.97 µM -1.54590756446864 0.0632082371829244 no 3150 0.0610634467054703 4546 2990173
SGTC_3011 9081274 71.4286 µM -1.5587377675658 0.0616774564837317 no 3151 0.0595292294581476 4532 6625322
SGTC_389 tpck 16.7 µM -1.55916147376837 0.0616274019430371 no 3152 0.0594790834048075 4561 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3228 9131799 49.47 µM -1.55941072341521 0.0615979716522996 no 3153 0.0594495999310779 4549 17015818
SGTC_1070 indatraline 8.81 µM -1.5618884871352 0.0613060048296954 no 3154 0.0591571305604578 4576 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2402 5553605 200 µM -1.56343333299375 0.0611245161372102 no 3155 0.0589753525051304 4562 6758546
SGTC_2666 tannic acid 100 µM -1.57017261575495 0.0603376915120672 no 3156 0.0581874792582233 4495 16134267 A thiamine antagonist.
SGTC_3230 9131665 49.47 µM -1.57128419492526 0.0602086773984688 no 3157 0.0580583253681226 4554 15943720
SGTC_2914 7968218 45.32 µM -1.58059978509428 0.059135946077571 no 3158 0.0569847875010144 4509 2977111
SGTC_1497 4476-2978 41.3 µM -1.58853365633068 0.0582341965969663 no 3159 0.0560828583641085 4587 1528379
SGTC_2024 5144227 134 µM -1.59113522131112 0.057940870750058 no 3160 0.0557895737300892 4510 3475211
SGTC_1552 6-methylflavone 10.6 µM -1.59650686308992 0.0573388946631302 no 3161 0.0551878373553218 4490 689013
SGTC_2158 5657123 3.6195 µM -1.59948100015829 0.0570077192118784 no 3162 0.0548568835014133 4546 2858827
SGTC_2862 9027634 71.43 µM -1.60582201330467 0.0563066653290459 no 3163 0.0541565112331534 4509 5012562
SGTC_1359 1582-0056 520 nM -1.61011537714571 0.0558358679426668 no 3164 0.0536863353524552 4583 3661189
SGTC_348 k064-0012 10.7 µM -1.61080800834056 0.0557602078679836 no 3165 0.0536107875396562 4501 5066323
SGTC_2115 tiliquinol 12.7705 µM -1.61209265906826 0.0556200923028822 no 3166 0.0534708889723547 4528 71208 A bioactive hydroxyquinoline.
SGTC_444 curcumin 90.4 µM -1.61216229850728 0.0556125047469896 no 3167 0.0534633135051816 4466 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1254 0550-0035 264 µM -1.61546261643561 0.0552538549410229 no 3168 0.0531052748500804 4538 15121435
SGTC_2913 7966556 36.57 µM -1.6220788862193 0.0545403601917476 no 3169 0.05239322917267 4461 2976516
SGTC_654 1124-0271 80.9 µM -1.62258145021775 0.0544864631105146 no 3170 0.0523394542687445 4559 5403748
SGTC_1835 st008666 49.2 µM -1.62341170867593 0.0543975149850717 no 3171 0.0522507117070457 4526 690455
SGTC_1397 3532-0190 20.1 µM -1.62353073229741 0.0543847730397481 no 3172 0.0522379996103084 4547 5322280
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.62934043360413 0.0537656869398762 no 3173 0.0516204855325452 4541 756377
SGTC_1995 st072814 61.1 µM -1.63190888274534 0.0534937762710423 no 3174 0.0513493412509517 4570 5769371
SGTC_1872 amphotericin b 148 nM -1.63496324384845 0.0531718437354957 no 3175 0.0510283765513619 4567 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2269 7935389 174.42 µM -1.64674749866969 0.0519441447415787 no 3176 0.0498049783619605 4580 97605
SGTC_1780 st038448 24.544 µM -1.66382908317254 0.0502046712502282 no 3177 0.0480732951148909 4597 728868 YDL195W SEC31
SGTC_558 k064-0027 21.3 µM -1.66608376728728 0.0499785794821441 no 3178 0.0478483656073807 4589 5088526
SGTC_1764 st044502 93.5 µM -1.66641366953889 0.0499455662480801 no 3179 0.0478155250097587 4595 8407
SGTC_1530 rhein 70.4 µM -1.67354196808654 0.0492364776994334 no 3180 0.0471103259279667 4651 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_569 4130-2812 160 µM -1.67427041414891 0.0491644704388679 no 3181 0.0470387331557697 4464 743552
SGTC_3218 9131285 49.47 µM -1.6746306702886 0.0491288900336245 no 3182 0.0470033588954879 4563 17156417
SGTC_829 1635-0120 117 µM -1.67786673103741 0.0488102044572539 no 3183 0.0466865592775125 4563 285054
SGTC_2738 aclarubicin 5.55 µM -1.68006079130813 0.0485950758850924 no 3184 0.0464727442492954 4625 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2747 doxorubicin 7.63 µM -1.6802263653798 0.0485788720850954 no 3185 0.0464566407128221 4642 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1450 4112-4260 37.6 µM -1.69339939418278 0.0473034851432847 no 3186 0.0451897350643232 4578 1633175
SGTC_3265 9137266 49.47 µM -1.6956770815018 0.0470857096087845 no 3187 0.0449735255686599 4575 17224265
SGTC_1773 st048542 73.5835 µM -1.70279086199666 0.046410714579303 no 3188 0.0443036067775197 4559 3237138
SGTC_2594 a-mangostin 100 µM -1.70419085209199 0.0462787949487906 no 3189 0.0441727188407087 4582 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_874 0599-0792 117 µM -1.70532447590205 0.0461721954927564 no 3190 0.0440669625910633 4583 765305
SGTC_3186 9110464 49.47 µM -1.70538373159563 0.0461666288563453 no 3191 0.0440614402215546 4587 17018021
SGTC_2576 guaiol 23.12 µM -1.70539543294913 0.0461655296640123 no 3192 0.0440603497729537 4498 227829
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.70646747420321 0.0460649142561904 no 3193 0.0439605385810564 4594 688662
SGTC_2834 9001755 58.44 µM -1.71166237252132 0.0455798443956748 no 3194 0.0434794533254695 4450 2989575
SGTC_353 1988-1175 58.3 µM -1.71441951016047 0.0453240717884088 no 3195 0.0432258539450348 4422 2788357
SGTC_1306 1185-0270 9.02 µM -1.72092836199818 0.0447248410499171 no 3196 0.0426319121152249 4606 1548076
SGTC_435 c-PAF 6.7 µM -1.72383483073602 0.044459328546899 no 3197 0.0423688323941015 4512 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2866 9034245 58.44 µM -1.72726106327409 0.0441479669908808 no 3198 0.0420603943090541 4605 6462273
SGTC_1559 coumarin 343 70.1 µM -1.72781430840133 0.0440978556517205 no 3199 0.0420107606389847 4634 108770 A hepatotoxic, DNA x-linker.
SGTC_2045 5106652 78.05 µM -1.72832579368544 0.0440515676063324 no 3200 0.041964915588042 4602 673349
SGTC_232 clozapine 119 µM -1.72833719295261 0.0440505364497158 no 3201 0.0419638943193587 4648 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.73038981136913 0.0438651774320148 no 3202 0.0417803264813816 4593 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2505 galangin 7.89 µM -1.74246244966951 0.0427876696762352 no 3203 0.0407137782886295 4550 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3139 9095020 49.47 µM -1.74277545519305 0.042760020400706 no 3204 0.0406864226709902 4503 25236292
SGTC_2870 9038528 12.99 µM -1.74715240103544 0.0423748947503465 no 3205 0.0403054529087484 4618 6463316
SGTC_3271 9137798 49.47 µM -1.75434536904664 0.0417480871017807 no 3206 0.0396856731096937 4609 6498326
SGTC_807 1315-0151 48 µM -1.75560835525422 0.0416388072095477 no 3207 0.0395776522975468 4601 4011080
SGTC_1400 3771-8998 51.5 µM -1.76411136233176 0.0409091025873214 no 3208 0.0388566159297102 4592 670767
SGTC_1338 1486-1223 76 µM -1.76552084256564 0.0407891531864122 no 3209 0.038738135240025 4618 3444526
SGTC_1415 3966-0071 78.1 µM -1.76620241040058 0.0407312529351718 no 3210 0.0386809484087319 4536 2893185
SGTC_1851 st056236 18.9 µM -1.76948515110331 0.0404533125407162 no 3211 0.0384064733113044 4597 5393171
SGTC_1767 st044992 70.3 µM -1.76980985558456 0.0404259046195612 no 3212 0.038379410762387 4619 9600693
SGTC_2084 5306078 60.6385 µM -1.77325883935211 0.040135709636709 no 3213 0.0380929130759026 4570 679340
SGTC_639 0833-0042 114 µM -1.7782549437889 0.039718344712969 no 3214 0.0376809963478853 4630 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2160 5660466 132.927 µM -1.77877878180656 0.0396747894403812 no 3215 0.0376380185830185 4569 2859134
SGTC_2625 euphol 100 µM -1.78068710939838 0.0395164471233092 no 3216 0.0374817900878935 4615 6708538 A triterpene alcohol.
SGTC_3137 9097352 49.47 µM -1.78653926390764 0.0390340708692019 no 3217 0.0370059928730398 4590 44120435
SGTC_2278 7948257 134.34 µM -1.79181012963663 0.0386037222855598 no 3218 0.0365816928230557 4623 1247028
SGTC_3153 9100258 49.47 µM -1.79412875566333 0.0384156425317672 no 3219 0.0363963101278584 4535 25236848
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.79594995836723 0.0382684365617762 no 3220 0.0362512380053426 4574 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1237 0330-0133 46.1 µM -1.79733781179441 0.0381565668486608 no 3221 0.0361410034346487 4582 X1237 YHR072W ERG7
SGTC_66 0109-0187 42.4 µM -1.80097607933209 0.0378645652365766 no 3222 0.0358533251641616 4466 759417
SGTC_2879 9041815 71.43 µM -1.8016836004893 0.0378079930348642 no 3223 0.0357975998536876 4662 4942971
SGTC_1423 4048-0112 5.59 µM -1.8025715589903 0.0377370909992992 no 3224 0.0357277635040543 4666 X1423
SGTC_3323 9138564 53.9225 µM -1.80297884689104 0.0377046060523282 no 3225 0.0356957684101884 4645 43912313 YNL103W MET4
SGTC_1972 st070201 17.4 µM -1.80978842912773 0.0371648526761557 no 3226 0.0351643014848055 4644 2829099
SGTC_230 MPP+ 141.667 µM -1.81088951230982 0.0370781725607848 no 3227 0.0350789781761133 4613 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_791 1348-1292 225 µM -1.81090426535881 0.0370770122853524 no 3228 0.0350778361117517 4615 5437054
SGTC_862 0452-0056 10.2 µM -1.81282342265811 0.0369263301355391 no 3229 0.034929530070563 4596 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1705 st027868 56.3335 µM -1.81328823979646 0.0368899105477433 no 3230 0.0348936880902377 4563 292948
SGTC_634 1611-4317 11.2 µM -1.81542927432975 0.0367225341353588 no 3231 0.0347289828468187 4654 2843522
SGTC_2797 7859098 81.82 µM -1.81836821694641 0.0364937928489082 no 3232 0.0345039363776673 4592 972681
SGTC_2439 5492030 7.2 µM -1.82186154258957 0.036223421163789 no 3233 0.0342379984244907 4636 5722370
SGTC_2504 purpurogallin 52.29 µM -1.83477145199614 0.0352384318256729 no 3234 0.0332697801084973 4595 5281571 An antioxidant.
SGTC_2032 5185112 25.99 µM -1.83609747732548 0.035138516164076 no 3235 0.0331716206704086 4524 5718189
SGTC_564 3555-0129 330 µM -1.84307914571668 0.0346162761979893 no 3236 0.0326587278364914 4593 563260
SGTC_1445 4239-0156 97.7 µM -1.8510975024427 0.0340243732268641 no 3237 0.0320777636742908 4675 4008346
SGTC_1169 aniline yellow 25.8 µM -1.85197399913309 0.0339601792171912 no 3238 0.0320147783246031 4599 6051 A DNA damaging agent.
SGTC_2800 7887935 81.82 µM -1.85368365570236 0.0338352517962528 no 3239 0.031892215687341 4622 2961002
SGTC_3010 9080089 71.4286 µM -1.87567255451489 0.0322619269936109 no 3240 0.0303501284055565 4656 17027233
SGTC_4 0960-0234 25.671 µM -1.88824203121454 0.0313900243174255 no 3241 0.0294967327818083 4613 6821112
SGTC_1171 0368-0077 21.4 µM -1.89512318908967 0.0309210130356016 no 3242 0.0290380415813805 4636 3239779
SGTC_251 melphalan 456.522 µM -1.9032366182374 0.0303754777365236 no 3243 0.0285048385086812 4691 460612 A DNA alkylator.
SGTC_2935 9038016 29.96 µM -1.90913380146135 0.0299839845565937 no 3244 0.028122416645945 4611 6463195
SGTC_2861 9024595 19.48 µM -1.91262906929485 0.0297539274921123 no 3245 0.0278977777577573 4644 16482810
SGTC_1647 st011722 22.4 µM -1.91791434752118 0.0294088357422951 no 3246 0.0275609363379009 4663 2854783
SGTC_338 4055-0136 114 µM -1.92094232425934 0.0292126317806456 no 3247 0.0273694895583916 4651 2900563
SGTC_116 0155-0182 31.788 µM -1.92818866632614 0.0287475015387884 no 3248 0.0269158317046005 4541 771486
SGTC_1499 4480-0877 67.3 µM -1.93621926425506 0.0282392416892328 no 3249 0.0264204260178845 4677 2861909
SGTC_1319 1306-0155 43.7 µM -1.93844003962123 0.0281000155300588 no 3250 0.0262847797371862 4700 3122360
SGTC_1805 st050013 60.3 µM -1.94799971836655 0.0275072038937779 no 3251 0.0257074984252958 4624 4037144
SGTC_2707 st078556 66.6 µM -1.95672306706037 0.0269753883015458 no 3252 0.0251900181827936 4612 17250899
SGTC_858 0438-0351 2.77 µM -1.96020995795084 0.0267652256566 no 3253 0.0249856275317362 4676 2799119
SGTC_2 0422-0095 29 µM -1.9618190215657 0.0266687058788541 no 3254 0.0248917791478827 4611 6790840
SGTC_2710 st078562 53.7235 µM -1.96430994772544 0.0265198610191213 no 3255 0.0247470793855569 4660 17250908
SGTC_3236 9132701 49.47 µM -1.9705299929901 0.0261512115455122 no 3256 0.0243888305244587 4698 24282524
SGTC_1167 k781-0610 148 µM -1.97166275364643 0.0260845385182029 no 3257 0.0243240591239617 4693 4525169
SGTC_633 0437-0093 97.7 µM -1.97241987117377 0.0260400547377912 no 3258 0.0242808476283337 4631 2831118
SGTC_2994 9053520 71.4286 µM -1.97262305432035 0.0260281276938859 no 3259 0.024269262192433 4669 4647384
SGTC_1758 st042942 75.2445 µM -1.97351012332125 0.0259761094099901 no 3260 0.0242187361724749 4653 669317
SGTC_609 0986-0026 86.3 µM -1.97738892091689 0.0257496747291657 no 3261 0.023998842666461 4673 2848610
SGTC_1364 1653-0028 37.6 µM -1.97844610130663 0.02568824641192 no 3262 0.0239392016582116 4695 5718652
SGTC_2430 5571206 200 µM -1.99597945477302 0.0246872151151046 no 3263 0.0229680795788445 4639 1731771
SGTC_1221 2958-7315 257 µM -1.99672883172128 0.0246451706579621 no 3264 0.022927324163219 4703 4562705
SGTC_185 k048-0037 25.491 µM -2.00258264633336 0.0243188005469868 no 3265 0.0226110520347429 4717 6827589
SGTC_2888 9058547 12.99 µM -2.00367795429757 0.024258138217158 no 3266 0.0225522846531644 4638 16476514
SGTC_1115 galangin 695.678 nM -2.00581147027147 0.0241403407813607 no 3267 0.0224381832050457 4736 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1201 1889-3372 45.9 µM -2.00914158243144 0.0239574364323727 no 3268 0.022261060431318 4605 5392199
SGTC_1398 3558-0053 112 µM -2.01994822714759 0.0233718911068164 no 3269 0.0216943790333582 4705 4532369
SGTC_1971 st069429 63.5 µM -2.02988839736866 0.0228439740683632 no 3270 0.0211839423663654 4688 1246522 YGL099W LSG1
SGTC_2563 tomatine 8.54 µM -2.03685323971258 0.0224800912395427 no 3271 0.0208323756105872 4615 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2848 9016370 25.97 µM -2.04619031112497 0.0219999486841206 no 3272 0.0203688251151104 4660 7894410
SGTC_1525 8-methoxypsoralen 92.5 µM -2.04747847981183 0.0219343914508532 no 3273 0.0203055638616417 4693 4114 Related to psoralen; DNA damaging agent.
SGTC_920 mycophenolic acid 780.421 nM -2.04975372375783 0.0218190031310861 no 3274 0.0201942347543931 4690 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_316 k060-0003 58.6 µM -2.05602421195213 0.0215036476030399 no 3275 0.0198900912426289 4717 6152314
SGTC_945 3381-0768 11.3 µM -2.06104879175587 0.0212537396388881 no 3276 0.0196491927346557 4684 1126236 YIL048W NEO1
SGTC_3142 9086498 49.47 µM -2.061686036688 0.021222221148595 no 3277 0.0196188184058622 4583 25236367
SGTC_340 k038-0059 454 µM -2.06286381090994 0.0211640718298323 no 3278 0.0195627846435334 4696 23733424
SGTC_217 ketoconazole 989 nM -2.06550685238874 0.0210340694863314 no 3279 0.0194375339242728 4532 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2426 5582046 32.21 µM -2.0740580690172 0.0206180843357243 no 3280 0.0190369590894056 4681 2251934
SGTC_234 nsc-17383 10.7 µM -2.07471055451424 0.0205866314776864 no 3281 0.0190066843009761 4712 408974
SGTC_2886 9058944 51.95 µM -2.08107806185156 0.0202818159469927 no 3282 0.0187133807588495 4702 4949929
SGTC_925 2064-1272 59.6 µM -2.08346430460092 0.0201685752032338 no 3283 0.0186044610543791 4680 6815817
SGTC_1086 cerivastatin 2.18 µM -2.08697105169167 0.0200031333524921 no 3284 0.0184453756914872 4712 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1176 0848-0131 83.3 µM -2.09620930913017 0.0195727918274235 no 3285 0.0180318137571205 4726 6769040
SGTC_2108 5365811 200 µM -2.09928633348209 0.0194312129216109 no 3286 0.0178958337134994 4715 780283
SGTC_1982 st072467 71.9 µM -2.10550461323744 0.0191477540072548 no 3287 0.0176237030872583 4697 3163533
SGTC_2999 9069765 71.4286 µM -2.10652146820776 0.0191017369596722 no 3288 0.0175795401492191 4659 2097066
SGTC_607 4491-0986 66.8 µM -2.11620744216737 0.0186680994522271 no 3289 0.0171635842733765 4697 698981 YDR232W HEM1
SGTC_3262 9137218 49.47 µM -2.12685967595078 0.0182009055749585 no 3290 0.016715872083977 4730 17650664
SGTC_934 2950-0684 338 µM -2.12853690758476 0.0181282598542795 no 3291 0.0166462966360021 4702 1121253
SGTC_432 NS 1619 61.3 µM -2.13187950619431 0.0179842191624154 no 3292 0.0165083766891307 4666 4552 A K+/calcium channel activator.
SGTC_2489 cantharidin 73.42 µM -2.13226577638303 0.0179676369156404 no 3293 0.0164925019087507 4674 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2122 5258151 111.688 µM -2.14955063329603 0.0172388416805753 no 3294 0.0157953884504224 4717 2173356
SGTC_3234 9132280 49.47 µM -2.15874628703457 0.0168615156803959 no 3295 0.0154349278243745 4729 17612295
SGTC_2667 digitoxin 100 µM -2.15997871437178 0.0168114861247865 no 3296 0.0153871587026153 4723 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1079 idarubicin 2.36 µM -2.18148282037706 0.0159587642387942 no 3297 0.0145738618885107 4738 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3177 9107506 49.47 µM -2.18893593869878 0.01567200143062 no 3298 0.0143007482467568 4723 8897194
SGTC_899 1083-0020 478 µM -2.18955725908543 0.0156482966776648 no 3299 0.0142781808089606 4745 767123
SGTC_1739 st037196 92.5 µM -2.21778366488986 0.0146033615788089 no 3300 0.0132847932156659 4718 612214
SGTC_3291 9121177 71.43 µM -2.22147729467856 0.0144711701838769 no 3301 0.0131593254470648 4700 17015612
SGTC_3 0833-0587 95.581 µM -2.23347826383974 0.0140487537982011 no 3302 0.0127587110743066 4642 5382644
SGTC_2000 st075254 36.4 µM -2.23375576448699 0.0140391132386416 no 3303 0.0127495737987468 4688 17234175
SGTC_3083 9117465 49.47 µM -2.23968419985036 0.0138345133091177 no 3304 0.0125557160191029 4701 16420915
SGTC_3086 9117350 49.47 µM -2.23997714306739 0.0138244703825494 no 3305 0.0125462033970446 4735 2679265
SGTC_959 1222-0044 107 µM -2.24152391558445 0.0137715468055778 no 3306 0.0124960790834197 4729 6083612
SGTC_2550 chrysin dimethyl ether 71.87 µM -2.25718347693017 0.0132455148532992 no 3307 0.0119983062188864 4674 88881 An O-methylated flavonoid and antioxidant.
SGTC_1545 lovastatin 49.4 µM -2.26017696585953 0.0131469593692832 no 3308 0.0119051349240335 4754 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2015 5119600 184 µM -2.26353900275923 0.0130370262189445 no 3309 0.0118012415707155 4697 2828786
SGTC_939 1165-0479 45.3 µM -2.27061701055401 0.0128081817124969 no 3310 0.0115850864014532 4710 1377347
SGTC_2919 7978188 46.38 µM -2.29040202662044 0.012186838421024 no 3311 0.0109990110818602 4716 2980291
SGTC_813 k007-0158 173 µM -2.29391263936277 0.0120793614205828 no 3312 0.0108977586318441 4720 6523916
SGTC_3185 9108267 49.47 µM -2.30116207005052 0.0118600188729158 no 3313 0.0106912359787021 4735 4910486
SGTC_2506 ethyl hematommate 54.16 µM -2.31691099069842 0.0113953879490585 no 3314 0.0102542904698531 4740 3940691 An allergen.
SGTC_2981 9013952 38.96 µM -2.33262143014713 0.0109477315617696 no 3315 0.00983401158636612 4691 2996344
SGTC_3096 9117468 49.47 µM -2.35150509626276 0.0104299716734626 no 3316 0.00934881674598052 4744 41316311
SGTC_659 k018-0002 107 µM -2.37205689222454 0.00989085233717057 no 3317 0.00884468334853939 4741 6797879 YHR007C ERG11
SGTC_2923 7992654 58.14 µM -2.38335080020466 0.00960507582072283 no 3318 0.00857791860741339 4719 2985126
SGTC_2973 9094665 17.96 µM -2.41787372406494 0.00877579359225957 no 3319 0.00780574670898961 4719 25237061 YIL048W NEO1
SGTC_449 xestospongin c 11.1929 µM -2.42256448017393 0.00866810422293146 no 3320 0.00770569524087936 4762 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1077 5-fluorocytosine 377 nM -2.42733402544595 0.00855979603960188 no 3321 0.00760512233442459 4776 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1388 3346-4487 254 µM -2.44359066351263 0.00819950460669421 no 3322 0.00727095764488347 4759 3345614
SGTC_249 wiskostatin 11.211 µM -2.46959239135549 0.00765090174495473 no 3323 0.00676335416314894 4750 2775510 A n-wasp and actin depolymerizer.
SGTC_84 0443-0269 128.823 µM -2.4982869506002 0.00708323011182826 no 3324 0.00623975654440302 4748 6150058
SGTC_1794 st048918 76.9 µM -2.49990554751177 0.00705234616437891 no 3325 0.00621132111285352 4761 672303
SGTC_2176 5809774 33.9695 µM -2.50648116149782 0.00692809755892275 no 3326 0.00609697776976084 4745 2870539
SGTC_1792 st045773 43.6 µM -2.5164519886348 0.00674338187079265 no 3327 0.00592715249797965 4758 2919270
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.52736005731267 0.00654630019910744 no 3328 0.00574618072191659 4776 4174840
SGTC_247 mechlorethamine 29.705 µM -2.52847096679918 0.00652651749241543 no 3329 0.00572802805219559 4777 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3003 9075612 71.4286 µM -2.54484898147684 0.00624093867894538 no 3330 0.00546625041247798 4764 6501993
SGTC_1770 st043884 66.3 µM -2.54890146579913 0.00617200738663321 no 3331 0.00540314138006768 4761 670149
SGTC_3004 9076122 71.4286 µM -2.55014420205464 0.00615100444002328 no 3332 0.0053839185360276 4765 44782551
SGTC_3162 9099653 49.47 µM -2.55239621804067 0.00611310537610542 no 3333 0.00534923885770028 4766 25237511
SGTC_2794 7785382 27.27 µM -2.57551079727894 0.00573591120777976 no 3334 0.00500460740847966 4755 2205081
SGTC_1457 k015-0032 57.3 µM -2.58648245105859 0.00556421190906587 no 3335 0.00484805538505059 4773 4302660
SGTC_3117 9124945 49.47 µM -2.59109165132213 0.0054934533254348 no 3336 0.00478360040746598 4755 17592065
SGTC_1945 st075991 56.6 µM -2.63453595603815 0.0048648089437486 no 3337 0.00421261898862977 4763 1084980
SGTC_803 4488-1585 147 µM -2.69652111293642 0.00407884845144699 no 3338 0.00350339778238592 4771 747204
SGTC_501 nsc-95397 161 µM -2.83874996357066 0.00268832351678143 no 3339 0.00226453153644929 4781 262093
SGTC_1426 4048-4480 71.7 µM -2.84031886436377 0.00267572717924279 no 3340 0.00225342298882209 4795 14224343
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.88335531330714 0.00235032730005041 no 3341 0.00196731676554916 4783 688667
SGTC_1406 3909-7906 11.9 µM -2.93217881156952 0.0020248576412613 no 3342 0.00168296443371784 4790 X1406
SGTC_2544 sphondin 68.51 µM -2.97034860580807 0.00179952267169285 no 3343 0.00148730991587218 4772 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1948 st076329 66.6 µM -2.9825706905465 0.00173234447666646 no 3344 0.00142919315046413 4766 24208413
SGTC_1983 st071813 46.9 µM -3.00626309005238 0.00160858117033762 no 3345 0.00132240028679201 4799 11838595
SGTC_2619 obliquin 87.91 µM -3.11856190144141 0.00112449609564506 no 3346 0.000908679811282069 4789 6708593 A bioactive alkalod. YER133W GLC7
SGTC_442 cape 100 µM -3.20272037569849 0.000853660144237521 yes 3347 0.000680680477818668 4796 5281787
SGTC_1132 3456-3614 2.5 µM -3.20601693382611 0.000844388426564907 yes 3348 0.000672930339916107 4770 3125502
SGTC_1128 3448-9350 235 µM -3.22622535116444 0.000789546633617943 yes 3349 0.000627172765472947 4773 619386
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -3.2400936196612 0.00075382918645979 yes 3350 0.000597452303633125 4799 7104
SGTC_115 0527-0192 112.043 µM -3.31999304631994 0.000575451334956256 yes 3351 0.000450098451635547 4776 4233931
SGTC_3248 9135562 49.47 µM -3.51549488858932 0.000290232701676129 yes 3352 0.000219467604551419 4799 17650701
SGTC_935 2996-0153 430 µM -3.65428376258185 0.000174895727050526 yes 3353 0.000128950456934659 4804 23738523
SGTC_366 0181-0206 4.31 µM -3.94182210123094 5.79865465419186e-05 yes 3354 4.04324733868611e-05 4799 274874
SGTC_3202 9113761 49.47 µM -4.29677814251504 1.33989780889424e-05 yes 3355 8.66492417165431e-06 4796 4798415
SGTC_335 4077-0256 27.6 µM -4.67961678955517 2.4295427268228e-06 yes 3356 1.43705801990341e-06 4795 3121989