SGTCid condition conc unit POP2|YNR052C.score POP2|YNR052C.strain.pval POP2|YNR052C.strain.significant POP2|YNR052C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1912 st060209 90.8 µM 8.89221873473816 6.38336188664427e-13 yes 1 2.99503160307438e-19 1 688787
SGTC_1026 k007-1105 30.6 µM 8.80807158815087 1.04190340399316e-12 yes 2 6.36585601672982e-19 15 7066794
SGTC_1624 st003710 6.25 µM 7.62029426896469 6.47032722541008e-10 yes 3 1.26549027705316e-14 7 24207033
SGTC_146 3448-8650 53.125 µM 7.29376827849417 3.23657572105884e-09 yes 4 1.50701826270292e-13 33 2891488 YIL048W NEO1
SGTC_1658 st012944 20 µM 6.9782657671094 1.43748055826186e-08 yes 5 1.49422970803168e-12 17 24207260
SGTC_3197 9113331 49.47 µM 6.66175124528282 6.01953213245564e-08 yes 6 1.35291868608738e-11 3 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2346 9031566 143.75 µM 6.39500847080757 1.91547950736554e-07 yes 7 8.02692278639066e-11 3 4771086
SGTC_1457 k015-0032 57.3 µM 6.3815119369162 2.02858491850935e-07 yes 8 8.7674025514109e-11 4 4302660
SGTC_1272 0839-0021 27 µM 5.96000509184749 1.14855046305729e-06 yes 9 1.26115036991721e-09 5 5027250
SGTC_2743 auranofin 4.32 µM 5.83617128203651 1.87112703491132e-06 yes 10 2.67069935558623e-09 12 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1687 st020778 55.3625 µM 5.79080460692693 2.23204287353854e-06 yes 11 3.50250157346486e-09 113 4259299
SGTC_2789 5281112 71.43 µM 5.78381478903754 2.29326606000592e-06 yes 12 3.65126706478575e-09 7 765948
SGTC_756 0508-1999 28.3 µM 5.76635482086317 2.453304010628e-06 yes 13 4.05022128440142e-09 3 6753853
SGTC_838 0109-0203 71.4 µM 5.68245438213913 3.3835308274446e-06 yes 14 6.63876677830536e-09 2 759422
SGTC_849 0386-0493 241 µM 5.6331684739525 4.07840699648115e-06 yes 15 8.84642313192216e-09 4 726119
SGTC_1693 xanthone 101.9 µM 5.50097561965709 6.68030915506723e-06 yes 16 1.88847719860156e-08 3 7020 An insecticide.
SGTC_1174 0739-0097 51.1 µM 5.48858309174496 6.99266381161092e-06 yes 17 2.02585332657095e-08 9 728447
SGTC_1070 indatraline 8.81 µM 5.44014127829084 8.35254375413769e-06 yes 18 2.66191677440493e-08 7 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_197 4544-0043 41.561 µM 5.34581730144333 1.17560213861704e-05 yes 19 4.50049824471522e-08 21 896523
SGTC_549 1661-1316 519 µM 5.33016463218899 1.24353931339016e-05 yes 20 4.90618874274836e-08 3 2857282
SGTC_1183 1254-0324 198 µM 5.3116649766789 1.32865013745927e-05 yes 21 5.43140840236334e-08 2 5799357
SGTC_2873 9040596 71.43 µM 5.25493914311028 1.62551487750865e-05 yes 22 7.40367129365148e-08 22 6463863
SGTC_351 caspofungin 25 nM 5.15177234118386 2.33363649068106e-05 yes 23 1.29018080409101e-07 51 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_770 0389-1121 67.2 µM 5.08605051108244 2.92799880835819e-05 yes 24 1.82798361561053e-07 10 6753108
SGTC_863 0466-0191 129 µM 5.08379198991957 2.95077656656904e-05 yes 25 1.84986553254936e-07 42 765160 YPR165W RHO1
SGTC_2050 5263056 171 µM 5.08062920637962 2.98295621182301e-05 yes 26 1.88093382275079e-07 25 763468 YGL055W OLE1
SGTC_1081 sertraline 6 µM 5.07465367220222 3.04466320534403e-05 yes 27 1.94101197135246e-07 16 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_733 4069-0007 56.1 µM 5.05767350648688 3.22667476271437e-05 yes 28 2.1220111704448e-07 54 5717425 YNL287W SEC21
SGTC_1654 st012436 41.8 µM 4.88026730694486 5.85520643806629e-05 yes 29 5.29710737639271e-07 6 4323132
SGTC_138 0850-0259 40.9225 µM 4.83627728489503 6.76699283878247e-05 yes 30 6.61466725273913e-07 152 6813004
SGTC_878 0828-0289 13.7 µM 4.83143948271308 6.87505463381108e-05 yes 31 6.77747108847461e-07 25 745350 YLR208W SEC13
SGTC_2926 9010726 65.15 µM 4.73160654206243 9.50280863179527e-05 yes 32 1.11374926373799e-06 19 2994293
SGTC_1785 bathophenanthroline 24 µM 4.68591393378682 0.000109975627828608 yes 33 1.39356688504038e-06 27 72812 An iron chelator.
SGTC_2340 7987427 183.45 µM 4.67787905797291 0.000112822266688871 yes 34 1.44928706857871e-06 18 2239331
SGTC_1216 1165-0504 9.65 µM 4.67154057280374 0.000115116546502774 yes 35 1.4947451589663e-06 5 6304004
SGTC_2322 7413319 38.22 µM 4.58509689178326 0.000151110484599102 yes 36 2.26887977579863e-06 120 1840400
SGTC_1377 2944-0135 198 µM 4.58499172878735 0.000151160081987003 yes 37 2.27002204016635e-06 22 1894137
SGTC_208 k072-0098 12.366 µM 4.53085046937607 0.000178820315095678 yes 38 2.9373354904467e-06 29 5948901
SGTC_755 1995-0008 37.3 µM 4.47230909433395 0.000214014233680521 yes 39 3.86897353806039e-06 14 689533
SGTC_1799 st045822 46.1415 µM 4.46001369449265 0.000222184415871871 yes 40 4.0977208062144e-06 6 3674992
SGTC_1268 0828-0275 2.46 µM 4.45063224822758 0.000228613116381612 yes 41 4.28089245715111e-06 12 745337
SGTC_1165 k072-0275 30.3 µM 4.43020701102478 0.000243214634079994 yes 42 4.70713365110787e-06 29 6153523 YGL055W OLE1
SGTC_2300 7976697 71.57 µM 4.37297170370324 0.000288895898474666 yes 43 6.1283307715379e-06 23 2236109
SGTC_2472 5377652 49.4 µM 4.35546701568005 0.000304388462951126 yes 44 6.63917557669591e-06 42 1610903
SGTC_3026 9090633 49.47 µM 4.29931210066435 0.00035946319842136 yes 45 8.56645304921306e-06 13 25236842
SGTC_2539 epi(13)torulosol 80 µM 4.28151180136586 0.000378767989787142 yes 46 9.28139385127224e-06 19 6708597
SGTC_3054 9094397 49.47 µM 4.2636965253403 0.000399049269057384 yes 47 1.00536245385113e-05 23 2598354
SGTC_2786 7743617 45.45 µM 4.26260993987608 0.000400318297358351 yes 48 1.01026517413993e-05 20 583674
SGTC_805 3852-0218 479 µM 4.24435735978588 0.000422203290451509 yes 49 1.09610379625256e-05 58 6615355
SGTC_1230 0170-0365 3.77 µM 4.22144614332306 0.000451244557928322 yes 50 1.21369978004343e-05 56 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1803 st050068 52.4 µM 4.21976256258813 0.000453449995193515 yes 51 1.22279875059058e-05 162 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1780 st038448 24.544 µM 4.21718474477234 0.00045684621963308 yes 52 1.23685651446277e-05 9 728868 YDL195W SEC31
SGTC_286 k060-0067 22.9 µM 4.18734947945152 0.000497906447887604 yes 53 1.41115536409646e-05 22 5985051
SGTC_651 3253-0966 34.4 µM 4.16271712401827 0.000534353322402078 yes 54 1.57241433457628e-05 28 781462
SGTC_1850 st056238 17 µM 4.13692450999491 0.000575150210770187 yes 55 1.75995923287029e-05 15 5393177
SGTC_206 4546-0025 72.014 µM 4.08817104086458 0.000660230009914783 yes 56 2.17393771021963e-05 62 6620745 YIL048W NEO1
SGTC_2753 fluvastatin 17.09 µM 4.06533391277845 0.000703951719147219 yes 57 2.39818705684787e-05 33 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1016 4226-1401 38 µM 4.02311228064339 0.000791886909534037 yes 58 2.87170491557233e-05 19 2901613
SGTC_93 0109-0045 59.227 µM 3.98767688530836 0.000873377076543525 yes 59 3.33617266007991e-05 46 88733
SGTC_1029 k015-0030 64.7 µM 3.96469149671264 0.000930286442139088 yes 60 3.67454649343775e-05 28 2208316
SGTC_800 3448-7362 155 µM 3.95255783264561 0.000961683511245203 yes 61 3.86601169012272e-05 163 15991913
SGTC_3114 9122766 49.47 µM 3.9098321340722 0.00108014568591176 no 62 4.6180141446952e-05 16 17176985
SGTC_176 1486-1328 72.834 µM 3.86530978296375 0.00121769924960829 no 63 5.54741445800488e-05 56 22310231
SGTC_3218 9131285 49.47 µM 3.86240676474973 0.00122720237753693 no 64 5.61377100317404e-05 46 17156417
SGTC_2676 harmalol 100 µM 3.82721459770148 0.00134792845324153 no 65 6.48007593342194e-05 13 5459187 A monoamine oxidase inhibitor
SGTC_932 2857-0803 154 µM 3.82404562693293 0.00135931555608547 no 66 6.5639802126104e-05 28 674898
SGTC_3033 9090887 49.47 µM 3.80210358426246 0.00144060239186733 no 67 7.17363574703e-05 30 19325384
SGTC_724 3910-0327 137 µM 3.80155217677435 0.00144270113911552 no 68 7.18962246555554e-05 24 2885483
SGTC_2867 9039098 71.43 µM 3.79962766960826 0.00145004801725597 no 69 7.2456821570032e-05 39 6463460
SGTC_246 cycloheximide 667 µM 3.78358124811993 0.00151264813465053 no 70 7.7293914603043e-05 17 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1154 4088-0362 150 µM 3.78098116060916 0.00152302056583059 no 71 7.8105748144361e-05 24 6618304
SGTC_2749 bexarotene 57.39 µM 3.73548389410435 0.00171533876659568 no 72 9.367728556008e-05 30 82146 An retinoic acid receptor inhibitor.
SGTC_1773 st048542 73.5835 µM 3.72211928227137 0.00177589184420053 no 73 9.87788254865187e-05 51 3237138
SGTC_1461 k072-0203 53.8 µM 3.68563747415638 0.00195121450431816 no 74 0.000114065448350771 20 5418714
SGTC_2398 5228213 48.84 µM 3.68252819354299 0.0019668610505039 no 75 0.000115466159445195 47 80771 YMR134W ERG29
SGTC_1697 st025554 27.742 µM 3.6734363333114 0.00201326912221572 no 76 0.00011965516203982 27 1269519
SGTC_2314 7727897 200 µM 3.66418911744105 0.00206148775131866 no 77 0.000124061704029751 32 900724
SGTC_2748 diazoxide 86.69 µM 3.65597037465094 0.00210522055859436 no 78 0.00012810547236208 11 3019 A potassium channel activatior.
SGTC_1180 1193-0155 285 µM 3.65338501188524 0.00211915054610471 no 79 0.000129402858398926 20 2921347
SGTC_3133 9127736 49.47 µM 3.63762881798938 0.00220586757697196 no 80 0.000137579790932432 30 27243420
SGTC_1952 st077036 64.1 µM 3.62162608683386 0.00229722148447462 no 81 0.000146378529145594 44 2937007
SGTC_3295 9122362 53.5725 µM 3.59966535245971 0.0024281656315963 no 82 0.000159313485026357 23 4730473
SGTC_1170 0310-0127 64.8 µM 3.58826654019951 0.00249876199535461 no 83 0.000166441942087072 39 774975
SGTC_528 3492-0019 172 µM 3.58070600469929 0.00254660504204446 no 84 0.000171333525551887 252 2869262
SGTC_2981 9013952 38.96 µM 3.57914697693046 0.00255657294401716 no 85 0.000172358782748323 55 2996344
SGTC_2934 9036370 36.88 µM 3.56932311784611 0.00262019874828694 no 86 0.000178952386399516 44 6462800
SGTC_2396 5342950 42.78 µM 3.56730456590781 0.00263344806074277 no 87 0.000180336095009005 62 1886677
SGTC_2619 obliquin 87.91 µM 3.56562378873486 0.00264452644051134 no 88 0.000181495887440359 170 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 3.5538943012407 0.00272301732830321 no 89 0.000189785866096925 32 688667
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 3.54974623731014 0.00275127461064812 no 90 0.000192801328431643 35 688761
SGTC_3217 9129673 49.47 µM 3.53304553465933 0.00286773960106948 no 91 0.000205400855149522 57 17248312
SGTC_301 4119-0100 24.5 µM 3.517242720718 0.00298201765963104 no 92 0.000218027422336652 97 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2758 dehydroepiandrosterone 69.35 µM 3.51354594506904 0.00300933623391639 no 93 0.000221083968424141 55 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1752 st044819 83.042 µM 3.50637665562885 0.0030629596228638 no 94 0.000227125958081831 35 441209 YML126C ERG13
SGTC_2755 lomerizine 42.69 µM 3.50468069848541 0.00307576989722824 no 95 0.000228577606446073 35 3949 A calcium channel blocker.
SGTC_1982 st072467 71.9 µM 3.48505487436661 0.00322756074971115 no 96 0.000246018062066633 51 3163533
SGTC_1562 morin hydrate 59.1 µM 3.45716167726959 0.00345489314682663 no 97 0.000272948613262622 31 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3188 9110789 49.47 µM 3.44809306872588 0.00353184335672444 no 98 0.000282279733887458 41 849217
SGTC_91 0417-1751 58.384 µM 3.43834231166355 0.00361629559827113 no 99 0.000292643654981344 69 6795624
SGTC_2745 rifampicin 24.3 µM 3.43816141123217 0.00361787937374602 no 100 0.000292839236175029 6 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2860 9025725 38.96 µM 3.42649167637653 0.00372137210032548 no 101 0.000305716250573684 23 40546248
SGTC_467 ro 31-8220 72.8 µM 3.40322369987198 0.00393568273632674 no 102 0.00033297865778881 114 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2499 avocadenofuran 51.48 µM 3.40172802965599 0.00394982955177286 no 103 0.000334806198405898 61 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_140 0062-0056 502.533 µM 3.36691840780427 0.00429220402671212 no 104 0.000380065873128311 43 3758964
SGTC_1073 triclabendazole 3.09 µM 3.36537306555677 0.00430800064291205 no 105 0.000382201146366024 57 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_649 1123-0311 367 µM 3.33809890417815 0.00459548309256517 no 106 0.00042176858995168 108 693629 YIL048W NEO1
SGTC_1797 st048695 56.8 µM 3.33738170601249 0.00460326846144468 no 107 0.000422858569241713 95 592262 YIL048W NEO1
SGTC_268 camptothecin 39.6153 µM 3.32511860209056 0.00473822130873196 no 108 0.000441904648978995 114 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1514 1189-1591 158 µM 3.3100563655846 0.00490879949520895 no 109 0.000466385927759969 71 767698 YMR146C TIF34
SGTC_788 1182-0090 188 µM 3.28537307590485 0.00520018813900701 no 110 0.000509237087255501 122 5715185
SGTC_1207 2099-0101 141 µM 3.28001007739716 0.0052654980987057 no 111 0.000519016893861982 48 5837381
SGTC_1363 1636-0063 10.4 µM 3.27202960619952 0.00536403420705829 no 112 0.000533891969360289 54 6072185
SGTC_3111 9122088 49.47 µM 3.24411478690095 0.0057217239171434 no 113 0.000589081285314317 12 16876704
SGTC_1801 st050089 28.441 µM 3.21083919021652 0.00617564576440088 no 114 0.00066173987145553 177 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2938 9059746 27.26 µM 3.19878157450053 0.00634783620424263 no 115 0.000690048441337495 69 6471769
SGTC_2908 7930301 100 µM 3.19829174551831 0.00635492022755689 no 116 0.000691221716932199 63 2223178
SGTC_1826 st055655 41.6 µM 3.19611964632983 0.00638641802296622 no 117 0.00069644669445295 75 676168
SGTC_2444 5485484 36.41 µM 3.19529393476397 0.00639842793180536 no 118 0.000698442477147684 68 6790631
SGTC_2521 angolensin 13.4 µM 3.18766356962401 0.00651036012263248 no 119 0.000717136548175709 31 821428 A flavenoid.
SGTC_2550 chrysin dimethyl ether 71.87 µM 3.18746397762846 0.00651331110042223 no 120 0.000717631673354059 19 88881 An O-methylated flavonoid and antioxidant.
SGTC_848 0368-0089 85.6 µM 3.18472429176061 0.00655393723612881 no 121 0.000724459899721864 36 762535
SGTC_2526 patulin 37.61 µM 3.17864937392584 0.00664482099089484 no 122 0.000739814785070219 148 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_117 lucigenin 22.078 µM 3.17495335881012 0.00670065869938584 no 123 0.000749302935564934 139 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1981 st071826 47 µM 3.15473880023792 0.00701344809728157 no 124 0.00080320926836967 35 11838600
SGTC_2077 5212015 200 µM 3.14296760195057 0.00720146681703189 no 125 0.000836221749295159 106 780900
SGTC_1308 1187-1617 41.4 µM 3.13095647132394 0.00739788642607274 no 126 0.000871189920335335 89 2882570
SGTC_2507 purpurin 79.67 µM 3.13013107187819 0.00741155604475287 no 127 0.000873641608930055 79 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1903 st060211 78.3 µM 3.11861087141415 0.00760468094885299 no 128 0.000908528818274106 64 688960
SGTC_2443 5493264 126.67 µM 3.11040285336509 0.00774497039772389 no 129 0.000934161704817134 50 5340055
SGTC_2477 5967686 25.23 µM 3.10595120905437 0.007822005391135 no 130 0.000948340041363265 61 776118
SGTC_1666 st014829 29 µM 3.09457743408796 0.00802189598782459 no 131 0.000985467395073848 54 3858230
SGTC_1519 esterone 74 µM 3.09315592122261 0.00804719168359287 no 132 0.000990200273956235 57 698 A steroid.
SGTC_885 0865-0106 16.8 µM 3.04791357079399 0.00888976158088946 no 133 0.00115218096939604 73 2793380
SGTC_3142 9086498 49.47 µM 3.04470342109136 0.00895238161995468 no 134 0.00116454931144195 81 25236367
SGTC_3332 9141069 11.198 µM 3.02111144706743 0.00942456052303317 no 135 0.00125924322076697 51 17332883
SGTC_888 0916-0002 6.97 µM 3.02048662897764 0.00943735650665191 no 136 0.00126184425392858 81 2802138 YIL048W NEO1
SGTC_2440 5628896 157.78 µM 3.02022501697248 0.00944271870985718 no 137 0.00126293476815362 51 5522048
SGTC_1278 0874-0585 172 µM 3.00934217770319 0.00966815558421666 no 138 0.00130907031633106 52 766306
SGTC_933 2914-0560 114 µM 3.00092819784935 0.00984566031110777 no 139 0.00134579012213927 72 463887
SGTC_2106 5357045 167.29 µM 2.999719973648 0.00987138178322682 no 140 0.00135113958738675 56 668842
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.98204511251977 0.0102544183944074 no 141 0.00143164901783836 48 16486 A toxic proline analog.
SGTC_3118 9124250 49.47 µM 2.98190233836586 0.0102575645383602 no 142 0.00143231682345712 38 1504786
SGTC_1935 st074532 41.6 µM 2.95299436288969 0.0109121700616382 no 143 0.00157353854951297 92 2829742
SGTC_2352 9027995 87.8 µM 2.93448407357274 0.0113501616319861 no 144 0.00167051349410547 67 2997347
SGTC_3049 9092223 49.47 µM 2.92369557530978 0.0116124226735426 no 145 0.00172951426410871 74 8623917
SGTC_780 0109-0199 192 µM 2.91487394744729 0.0118307648744418 no 146 0.00177916115636994 69 610414
SGTC_2666 tannic acid 100 µM 2.91367678243766 0.0118606684380138 no 147 0.00178599763659088 89 16134267 A thiamine antagonist.
SGTC_199 4063-0024 41.6 µM 2.90441789997021 0.0120941655811774 no 148 0.00183968343700638 29 306215
SGTC_1805 st050013 60.3 µM 2.89405491224214 0.0123602233272934 no 149 0.00190150823830272 33 4037144
SGTC_2523 spermine 47.74 µM 2.89382456348101 0.0123661944147888 no 150 0.00190290368195224 69 1103 A DNA binding polyamine.
SGTC_2831 7999036 19.48 µM 2.88821329170752 0.0125124232323445 no 151 0.00193718527521319 119 2988270
SGTC_194 1486-1323 56.904 µM 2.88603572085114 0.0125695722889963 no 152 0.00195063937944938 55 5178754
SGTC_629 3448-6466 76.7 µM 2.88055731359222 0.0127143501509118 no 153 0.00198486384998196 70 573744
SGTC_2401 5128683 200 µM 2.86989048868141 0.0130003861178329 no 154 0.00205306990918189 92 708373
SGTC_2900 5328528 85.29 µM 2.86325508970988 0.0131811102965185 no 155 0.00209656417048584 95 795359
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.84730364664674 0.0136244746764118 no 156 0.00220456422587414 135 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2085 5307070 144.047 µM 2.84251000751189 0.0137602021350152 no 157 0.00223799129313916 76 2840351
SGTC_3141 9094609 49.47 µM 2.83947171274497 0.0138468312136917 no 158 0.0022594150696688 103 25236309 YDL196W YDL196W
SGTC_660 4031-1742 102 µM 2.83920892933408 0.0138543458503365 no 159 0.00226127672288326 115 6738706
SGTC_330 1488-0319 80.1 µM 2.82635058635983 0.0142263684947273 no 160 0.00235408514758057 64 6846614
SGTC_1417 3966-0327 90.4 µM 2.8239031304864 0.0142981457853425 no 161 0.00237213606790785 73 651118
SGTC_1500 4488-1866 171 µM 2.81628442954166 0.0145235818313381 no 162 0.00242913171926465 76 2900003
SGTC_2737 bleomycin 30.5 nM 2.81209881547431 0.0146487305568465 no 163 0.00246096900074145 157 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_329 k048-0121 21.3 µM 2.81096231278413 0.0146828714317315 no 164 0.00246967855655476 63 6832902
SGTC_2134 5324836 1.464 µM 2.80345654747879 0.0149100702792994 no 165 0.00252790222444083 62 699272
SGTC_1910 st062352 60.4 µM 2.80270819750565 0.0149328875970744 no 166 0.00253377482158957 106 2245730
SGTC_667 1498-1044 59 µM 2.79651408523053 0.0151229023164695 no 167 0.00258285796248576 77 6739982
SGTC_228 caffeine 993.056 µM 2.78646756314739 0.0154355136081521 no 168 0.00266429753580831 45 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2627 acetyl isogambogic acid 100 µM 2.78415258937525 0.0155083285763879 no 169 0.00268338898411735 118 6857789 A caspase activator and apoptosis inducer.
SGTC_1077 5-fluorocytosine 377 nM 2.77806474922524 0.0157012235660363 no 170 0.00273418600932418 62 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_954 1189-0853 2.85 µM 2.75079504282651 0.0165907310090789 no 171 0.00297254136189366 110 2828194
SGTC_1904 st060225 78 µM 2.74694998984772 0.0167195574062421 no 172 0.00300761529157976 70 66595
SGTC_14 0354-0009 295 µM 2.74558220021453 0.0167655903525416 no 173 0.00302018166605048 90 1713507
SGTC_1763 st044482 94.5 µM 2.74170800648014 0.0168965651564511 no 174 0.00305603240482155 80 88505
SGTC_2254 7938975 95.19 µM 2.73900006348371 0.0169886311916034 no 175 0.00308131807706789 125 2969277
SGTC_2885 9057732 51.95 µM 2.73232829861647 0.0172172929952478 no 176 0.00314442206313648 70 6471414
SGTC_1176 0848-0131 83.3 µM 2.73025759872529 0.0172887947998996 no 177 0.0031642427062481 92 6769040
SGTC_195 4234-0266 16.654 µM 2.72928075394152 0.0173226134623974 no 178 0.00317363199565131 108 2303354
SGTC_1781 st038725 66.3 µM 2.71689443436343 0.0177563555738622 no 179 0.00329488112335284 194 4270275 YIL048W NEO1
SGTC_524 r073-0010 27.8 µM 2.71465377673482 0.0178358002524906 no 180 0.00331725452865579 131 2772106
SGTC_808 0711-0032 135 µM 2.71452478899413 0.017840382852187 no 181 0.00331854664486999 75 4252555
SGTC_802 4112-3352 742 µM 2.7123822165275 0.0179166499114422 no 182 0.0033400758459054 96 704594
SGTC_2189 6047310 154.431 µM 2.70193474671185 0.0182925337811247 no 183 0.00344686451557501 70 711535
SGTC_3178 9107506 49.47 µM 2.69343582857504 0.0186032482018494 no 184 0.00353598788297917 79 8897194
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.68962951797745 0.0187438543309664 no 185 0.00357656916078721 108 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_401 neomycin 50 µM 2.68668767927745 0.0188531453248339 no 186 0.00360821970867547 63 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1403 3909-7815 62.9 µM 2.68060450520057 0.0190808591962407 no 187 0.00367446568617691 69 6615483
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.6772661575098 0.0192068157872341 no 188 0.0037112822681357 79 6708784 An antioxidant flavonoid
SGTC_3174 9107204 49.47 µM 2.67142145518022 0.0194290397103735 no 189 0.00377653733990162 110 3938802
SGTC_1810 st050138 53 µM 2.66953053402324 0.0195014012881004 no 190 0.00379786832543183 62 3444541
SGTC_1291 0993-0025 5.79 µM 2.65785199467142 0.0199534055560679 no 191 0.00393202102790855 61 4353356
SGTC_2898 9056270 58.44 µM 2.65079839086008 0.0202306892061211 no 192 0.00401508797124229 47 19154699
SGTC_1120 ficusin 1.78878 µM 2.64031816649468 0.0206487056576223 no 193 0.00414141133319967 95 6199 A DNA cross-linker.
SGTC_2081 5214970 32.255 µM 2.6342001849749 0.0208960938016707 no 194 0.00421678743543474 94 2063512
SGTC_1153 4055-0057 267 µM 2.62900695795562 0.0211080526906462 no 195 0.00428173043827915 114 882706
SGTC_3233 9132340 49.47 µM 2.6252857116393 0.0212610497097027 no 196 0.00432881427921843 86 17682950
SGTC_3194 9111903 49.47 µM 2.62496595604469 0.021274239933976 no 197 0.00433288156383837 96 17087251
SGTC_2821 7996764 71.43 µM 2.62393871682891 0.0213166613722319 no 198 0.00434597114787352 156 2987135
SGTC_1610 st001799 48.1 µM 2.61404213988518 0.0217290323865296 no 199 0.0044738999861447 76 621897
SGTC_352 k048-0007 5.11 µM 2.60279369415124 0.0222058960046474 no 200 0.00462337889281116 166 6811911
SGTC_211 3455-0679 143.504 µM 2.59254447568014 0.0226480582333574 no 201 0.00476344311148174 96 748649
SGTC_167 3672-0051 66.205 µM 2.59250568558403 0.0226497456747324 no 202 0.00476398032120174 131 3237971
SGTC_2203 7227154 166.4 µM 2.59042457854388 0.0227404331981241 no 203 0.00479288119976714 70 896304
SGTC_1218 1348-1416 30.7 µM 2.57762171958862 0.0233050949261129 no 204 0.00497414187739339 93 6787668
SGTC_1161 k007-0610 110 µM 2.56233253978701 0.0239948299449891 no 205 0.00519858570998604 237 5843850
SGTC_1633 st005664 67.9 µM 2.55159243021561 0.0244895349622539 no 206 0.00536159384035068 148 2063822
SGTC_1407 3909-7909 12.3 µM 2.54977238804994 0.0245742112746562 no 207 0.00538966343075622 88 4411780
SGTC_384 k007-0144 5.16 µM 2.54830574140541 0.0246426247295664 no 208 0.00541237775529593 170 6824886
SGTC_3270 9137563 49.47 µM 2.54331967719199 0.0248764017976903 no 209 0.00549023586874714 70 17015724
SGTC_2959 9079155 11 µM 2.53879870467646 0.0250899775041605 no 210 0.00556169013528446 107 16189457
SGTC_2172 5754775 163.918 µM 2.53619913408382 0.0252134785551926 no 211 0.00560314951595967 114 2263357
SGTC_3038 9091290 49.47 µM 2.53589190689725 0.025228107984399 no 212 0.00560806743529869 104 25236843
SGTC_614 0462-0418 107 µM 2.52732853271971 0.0256387465888041 no 213 0.00574669658950638 132 5188303
SGTC_2810 7959871 45.46 µM 2.52464988005094 0.0257683390249354 no 214 0.00579068039686398 146 2974535
SGTC_517 1365-0151 113 µM 2.52297159792755 0.0258498128283622 no 215 0.00581838996510723 126 768657
SGTC_56 0957-0365 83.25 µM 2.52221344559786 0.0258866886756847 no 216 0.00583094610032283 153 6752360
SGTC_3105 9121040 49.47 µM 2.52090521333949 0.0259504234168768 no 217 0.00585266891784233 28 41448907
SGTC_718 1130-0073 349 µM 2.50546581120805 0.0267125704374333 no 218 0.00611451101981771 114 6740020
SGTC_1430 4049-0248 69.1 µM 2.5052323846992 0.0267242351873256 no 219 0.00611854818080004 121 22774488
SGTC_1844 rapamycin 4 nM 2.50457409249908 0.0267571541703369 no 220 0.00612994620871523 311 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_263 alizarin 107.927 µM 2.50050642360972 0.0269613165447331 no 221 0.006200794197818 203 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_518 1021-0119 62.6 µM 2.49650236393312 0.0271635546242183 no 222 0.00627124163857675 150 1097762
SGTC_2813 7971799 71.43 µM 2.49580249790522 0.0271990332638748 no 223 0.00628362757936999 117 2234054
SGTC_1534 6-azauridine 81.6 µM 2.4947908679969 0.0272503846182522 no 224 0.00630156926840676 132 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_575 k072-0246 11.9 µM 2.49062463296989 0.0274627200404846 no 225 0.00637593812860431 124 6796779
SGTC_281 1672-3440 14.9 µM 2.48570152018407 0.0277154067640901 no 226 0.00646481796020611 78 6833000
SGTC_1249 0481-0015 10.2 µM 2.47911834999855 0.0280563234961859 no 227 0.00658537981574527 114 4227577
SGTC_2383 9036125 200 µM 2.47887221787403 0.0280691371409506 no 228 0.00658992569495402 59 79580
SGTC_2647 atorvastatin 60.16 µM 2.47511046463512 0.0282655812346356 no 229 0.0066597485824481 99 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_750 4073-0104 132 µM 2.46791037934417 0.0286447715018675 no 230 0.00679521703205309 83 22330957
SGTC_1313 1220-0047 237 µM 2.46507671263943 0.0287951613320183 no 231 0.00684919601514398 149 3528706
SGTC_3028 9087778 49.47 µM 2.46328314271612 0.0288906894163787 no 232 0.00688355742306828 95 17217395
SGTC_2986 9022445 71.43 µM 2.45113602352255 0.0295446183415967 no 233 0.00712030637115023 126 6459286
SGTC_1606 st000094 49.2 µM 2.44894746772109 0.0296637336778337 no 234 0.00716371713135871 119 1242210
SGTC_1870 st057514 26.5 µM 2.44289036051057 0.0299954798464674 no 235 0.00728508146257176 134 5393161
SGTC_2012 4023501 200 µM 2.43829064457394 0.0302494553721755 no 236 0.00737845188916425 131 3477460
SGTC_831 k061-1017 217 µM 2.43780493398375 0.0302763778496026 no 237 0.00738837271291348 238 1240153
SGTC_1989 st071868 50.2 µM 2.43019978458377 0.0307005201264929 no 238 0.00754525102790374 113 16414057
SGTC_2896 9052656 71.43 µM 2.42274421237979 0.0311210844667195 no 239 0.0077018841996876 303 6469436
SGTC_557 1315-0110 16.2 µM 2.41229452912225 0.0317185562420135 no 240 0.0079262349104304 151 6833801
SGTC_2174 5790901 200 µM 2.40987959517944 0.0318579725790273 no 241 0.00797889297703045 152 786020
SGTC_949 1165-0505 146 µM 2.40038965851123 0.0324107467028244 no 242 0.00818881378450558 144 6244267
SGTC_1681 tripelennamine 100 µM 2.3969734240586 0.0326116642187568 no 243 0.008265561329305 107 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_485 niflumic acid 177 µM 2.39573063795272 0.032685010003144 no 244 0.00829363750120505 98 4488 A COX2 inhibitor.
SGTC_347 4534-1311 26.2 µM 2.39504361762218 0.032725614383267 no 245 0.00830919411229854 119 2862016
SGTC_3294 9122953 26.2835 µM 2.39248874167463 0.0328769781369244 no 246 0.00836727074782031 133 16459826
SGTC_3175 9106517 49.47 µM 2.39165533073857 0.0329264782577294 no 247 0.00838629251817497 105 41468073
SGTC_1505 k297-0037 20.6 µM 2.38843403738611 0.0331183836142365 no 248 0.00846017272305463 136 4089396
SGTC_2775 cyproheptadine 69.59 µM 2.38805224581083 0.0331411894254872 no 249 0.0084689668463314 109 2913 A selective serotonin reuptake inhibitor.
SGTC_1382 3002-2117 298 µM 2.37758887901856 0.0337712577731531 no 250 0.0087131214016626 103 1497314
SGTC_2671 danthron 100 µM 2.37597813878629 0.0338691208391561 no 251 0.00875124986868906 165 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_868 0527-0199 213 µM 2.36940173844474 0.0342711039131577 no 252 0.00890844436227053 141 2849450
SGTC_2571 chrysanthemic acid 100 µM 2.36619182591501 0.0344687296088969 no 253 0.00898606486556556 117 2743 An insecticide.
SGTC_814 3342-0569 96 µM 2.35469313638887 0.0351843715641935 no 254 0.00926900367490508 157 4346283
SGTC_1712 st032288 53.4 µM 2.3517877565489 0.035367109560553 no 255 0.00934171609264644 361 2883011
SGTC_1201 1889-3372 45.9 µM 2.34188525089688 0.0359957975530698 no 256 0.0095933064494715 98 5392199
SGTC_3245 9134821 49.47 µM 2.3377282795523 0.0362624282715325 no 257 0.00970067409507103 152 17014901
SGTC_23 0213-0011 39.996 µM 2.33446733757542 0.0364727168771951 no 258 0.00978563220738517 137 627608
SGTC_2944 9067346 25.62 µM 2.33331597191291 0.0365472030289408 no 259 0.00981578388710746 170 6473075
SGTC_981 1488-1094 54.9 µM 2.32903629110524 0.0368251634247107 no 260 0.00992857160858492 101 3449522
SGTC_1365 1672-3266 55.4 µM 2.32621428625203 0.0370093934256989 no 261 0.0100035609540266 140 6415873
SGTC_51 1013-0126 23.419 µM 2.30557597324475 0.0383797487223588 no 262 0.0105671685507047 132 1627850
SGTC_1413 3910-0535 34.4 µM 2.30252718413968 0.0385856470213876 no 263 0.0106527301069447 123 2876951
SGTC_250 brefeldin a 552.239 µM 2.29795012334755 0.0388964454705731 no 264 0.0107823140141015 103 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3093 9117344 49.47 µM 2.29675654040215 0.0389778282112515 no 265 0.0108163310173777 139 24824913
SGTC_1055 3448-0672 86 µM 2.29275467657768 0.0392517018054715 no 266 0.0109310663648282 167 748378
SGTC_2703 st077852 53.4 µM 2.29107014541635 0.039367452630125 no 267 0.0109796785042144 146 6281836
SGTC_663 1486-0733 13.9 µM 2.29024755366909 0.0394240770149129 no 268 0.0110034850988371 204 722445 YPR165W RHO1
SGTC_1189 1431-2119 7.28 µM 2.28060573778112 0.0400927390446425 no 269 0.0112858937356382 200 3107275
SGTC_546 peri-Naphthalide 147 µM 2.26352626577108 0.0412998036430022 no 270 0.0118016336785796 143 223824 A penicillin ester.
SGTC_1959 st077091 55.8 µM 2.25855163721038 0.0416568649134887 no 271 0.0119556445390754 185 821356 YKL052C ASK1
SGTC_1008 4106-0037 6 µM 2.25833753636465 0.0416722882675585 no 272 0.0119623118901751 130 2905394
SGTC_1449 4112-4002 201 µM 2.2557058417705 0.0418622478772504 no 273 0.0120445297413335 135 2059539
SGTC_1830 st055982 50.3 µM 2.24896519979066 0.0423519965100163 no 274 0.01225735511281 157 455313 An antimicrobial agent.
SGTC_1075 aripiprazole 15.2 µM 2.24581695274154 0.0425823184363577 no 275 0.012357867492349 196 60795 An atypical antipschotic. YIL048W NEO1
SGTC_402 epigallocatechin gallate 10 µM 2.22710419080037 0.0439723005782984 no 276 0.0129701555989173 195 65064 An antioxidant.
SGTC_2257 7960413 200 µM 2.22250705866372 0.0443193151058821 no 277 0.0131245287685063 220 2974689 YIL048W NEO1
SGTC_2806 7952793 58.44 µM 2.22035888521197 0.0444822248910879 no 278 0.01319720782063 168 2972490
SGTC_1318 1280-3875 124 µM 2.2193549827202 0.0445585225055315 no 279 0.0132312918662315 202 373245
SGTC_1107 amlodipine 47 µM 2.21711344994212 0.0447292617859193 no 280 0.0133076699623535 189 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1086 cerivastatin 2.18 µM 2.21522596403995 0.04487344130106 no 281 0.0133722793018356 124 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1867 st057372 64 µM 2.21429806036388 0.0449444582001757 no 282 0.0134041409855895 148 688837
SGTC_3255 9139072 49.47 µM 2.21414181026262 0.0449564256617595 no 283 0.0134095126319508 149 17646060
SGTC_21 0849-0113 22.993 µM 2.20635389397708 0.0455561727874012 no 284 0.0136796152945548 204 1560156
SGTC_192 3455-0609 60.9 µM 2.2061958867455 0.0455684071794508 no 285 0.0136851435805804 146 3769639
SGTC_3324 9138759 60.749 µM 2.20487938303945 0.045670445893315 no 286 0.0137312798045297 162 45595710
SGTC_2236 dapsone 200 µM 2.20429500197195 0.0457157985443886 no 287 0.0137518021119203 152 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.20217713137793 0.0458804656784268 no 288 0.013826399390805 204 442882
SGTC_1612 st002233 45.4 µM 2.20215033069359 0.0458825525155114 no 289 0.0138273456169731 151 1035021
SGTC_3291 9121177 71.43 µM 2.20181516868978 0.0459086563690734 no 290 0.0138391835788783 148 17015612
SGTC_2274 7947094 46.08 µM 2.19195952832525 0.0466816049319807 no 291 0.0141912145429204 194 2971028
SGTC_2915 7971052 15.16 µM 2.17756941359201 0.0478288944571515 no 292 0.0147190543795965 96 5741558
SGTC_1922 5578187 25 µM 2.17634604202288 0.0479274631697975 no 293 0.0147646976022572 200 1350412
SGTC_893 0958-0369 48.9 µM 2.17626937133604 0.0479336460422032 no 294 0.0147675621867377 202 6819948
SGTC_1834 st055981 52.8 µM 2.16991654086407 0.048448172716368 no 295 0.0150065845133893 186 471719 YDL150W RPC53
SGTC_2856 9022925 19.48 µM 2.1671039045347 0.0486773791619888 no 296 0.0151134661382381 198 4944862
SGTC_2851 9015922 71.43 µM 2.16448444519489 0.0488916220673779 no 297 0.0152135945554857 189 2996893
SGTC_2648 atorvastatin 78.68 µM 2.162827969481 0.0490274919651163 no 298 0.0152772067606127 147 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_41 0478-0632 82.643 µM 2.15994644700483 0.0492645630371829 no 299 0.0153884077718982 226 3750424
SGTC_1024 4507-0395 26 µM 2.15631816754925 0.0495643728802177 no 300 0.0155294148066335 179 4201836
SGTC_2316 5844804 197.44 µM 2.14757758053363 0.0502926002132791 no 301 0.015873664011914 257 776813
SGTC_1682 st012968 530 nM 2.14077616543974 0.0508651430425409 no 302 0.0161460464608706 156 24207270
SGTC_136 0097-0015 404.482 µM 2.12887382488472 0.0518795567607111 no 303 0.0166323504548969 194 4861337
SGTC_248 streptozotocin 5.23457 mM 2.12880257805265 0.0518856770447539 no 304 0.0166352987756719 198 5300 DNA alkylating agent.
SGTC_3129 9127257 49.47 µM 2.11830682498755 0.0527935746842487 no 305 0.0170745455021261 180 837894
SGTC_859 0439-0102 54.6 µM 2.11653680077027 0.0529479188905017 no 306 0.0171495893711048 184 610143
SGTC_1772 st048439 82.2 µM 2.1162474142879 0.0529731870849466 no 307 0.0171618852825772 225 2927068 YDL195W SEC31
SGTC_2485 5633444 17.78 µM 2.11399138569383 0.0531705034860995 no 308 0.0172580015379785 228 5724239
SGTC_1327 1436-0082 2.18 µM 2.11133762744824 0.0534033513896863 no 309 0.0173716510145375 180 15992205
SGTC_58 0957-0393 9 µM 2.098449600421 0.0545456944818921 no 310 0.0179327238160306 654 6997992
SGTC_2241 6772625 37.8075 µM 2.09389469490153 0.0549540141127822 no 311 0.0181346809833081 190 2285411
SGTC_152 4469-0003 551.229 µM 2.09236866125658 0.0550913526806612 no 312 0.0182027749724029 167 697280
SGTC_1112 tnp00069 1.16933 µM 2.09122308015431 0.0551946297088252 no 313 0.018254035651512 203 145826
SGTC_558 k064-0027 21.3 µM 2.08980946953131 0.0553222809947418 no 314 0.0183174591883183 204 5088526
SGTC_1565 sinapyl alcohol 95.1 µM 2.08873176030966 0.0554197563871487 no 315 0.0183659380933154 203 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2200 6600604 21.907 µM 2.08742439325104 0.055538185581685 no 316 0.0184248944347021 224 2904777
SGTC_1588 farnesol 29.9 µM 2.07970567547975 0.0562414702375102 no 317 0.018776268606574 197 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2068 5226020 147 µM 2.07608042392888 0.0565741963278422 no 318 0.018943256694278 245 1810509
SGTC_2705 st078069 42.8 µM 2.07251485913955 0.0569029553301046 no 319 0.0191087259828311 172 1530061
SGTC_883 0850-0245 24.6 µM 2.07108535786815 0.0570351826627532 no 320 0.0191754099667874 227 6823229 YPR165W RHO1
SGTC_1439 4092-1168 46 µM 2.06936062450509 0.0571950405106588 no 321 0.0192561292909033 167 2886240
SGTC_2040 5100729 123 µM 2.06287016714168 0.057799774471627 no 322 0.0195624826087021 216 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1926 methyl fluorone black 53.6 µM 2.06143161985567 0.0579344860802412 no 323 0.0196309404190139 233 72721 Reacts with homocysteine.
SGTC_1254 0550-0035 264 µM 2.05904381490989 0.0581586347963144 no 324 0.0197450206865374 213 15121435
SGTC_1344 1488-0097 29.1 µM 2.05789637077036 0.0582665901166936 no 325 0.0198000411040272 188 747966
SGTC_507 nimesulide 162 µM 2.05644306915965 0.0584035473873599 no 326 0.0198699142461678 196 4495 A COX2 inhibitor.
SGTC_39 0986-0283 58.349 µM 2.05465442329668 0.0585724539803312 no 327 0.0199561975130116 245 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_77 0828-0286 12.516 µM 2.05455941279689 0.0585814367907204 no 328 0.0199607896435394 239 745345
SGTC_1873 rapamycin 2 nM 2.05163075085706 0.058858859309147 no 329 0.0201027806655327 273 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1158 4092-0494 91.8 µM 2.04375665481698 0.059609859726032 no 330 0.0204887965939224 194 1148199
SGTC_1284 0929-0043 16 µM 2.04049245675278 0.0599233792883381 no 331 0.0206506507921874 217 1239883
SGTC_2728 chlorpromazine 9.18 µM 2.03492009650212 0.0604615756460117 no 332 0.0209294567635688 117 2726 A thorazine and dopamine antagonist.
SGTC_2366 9070441 60.58 µM 2.03042055957147 0.0608989092787083 no 333 0.0211569042865534 234 6837235
SGTC_1011 4112-3381 17.4 µM 2.030330102903 0.0609077265311395 no 334 0.0211614981455443 236 2877139
SGTC_2433 5607874 27.82 µM 2.02735550937007 0.0611982311073563 no 335 0.0213130342228628 230 2252428
SGTC_2385 9074692 200 µM 2.02724587274852 0.0612089590860174 no 336 0.0213186369803179 245 17046906
SGTC_2611 pyromycin 23.93 µM 2.02669107434485 0.0612632688233285 no 337 0.0213470079299516 231 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2650 prasterone 100 µM 2.02526338448518 0.061403199841903 no 338 0.0214201630996555 118 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_690 glyoxal 20.3 µM 2.02062789394247 0.0618592562488759 no 339 0.0216591495871517 292 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_841 0251-0215 91.2 µM 2.02052525685131 0.0618693838950067 no 340 0.0216644665167804 282 3888614
SGTC_66 0109-0187 42.4 µM 2.01761271257262 0.0621573170245955 no 341 0.0218158059282521 230 759417
SGTC_947 3447-0010 211 µM 2.01243060019293 0.0626722022345924 no 342 0.0220872827597763 188 748350
SGTC_139 0099-0334 718.624 µM 2.01213622737379 0.0627015500621072 no 343 0.0221027893679277 266 97690
SGTC_96 0929-0093 37.281 µM 2.00288349694875 0.0636294815912317 no 344 0.0225948974249152 196 6991579
SGTC_1124 fisetin 1.16336 µM 1.99664826530257 0.0642607986374095 no 345 0.0229317029023318 223 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2250 alverine citrate 130 µM 1.98999127645 0.0649401806068646 no 346 0.0232959482379411 432 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1800 st050079 29.0735 µM 1.98931776450554 0.0650092256021158 no 347 0.0233330700490691 433 3645560
SGTC_2779 methotrexate 400 µM 1.98636201160067 0.0653129081657544 no 348 0.0234965707894193 239 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1108 betulinic acid 729.144 nM 1.97918673689755 0.0660546946430513 no 349 0.0238974928202708 220 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_715 0868-0130 184 µM 1.97648829064626 0.0663353453899143 no 350 0.0240497503190846 185 2876258
SGTC_43 0570-0105 72.5 µM 1.9726271041097 0.066738531224879 no 351 0.0242690313219759 393 1114046 YDL195W SEC31
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.96929048716829 0.0670884664772515 no 352 0.0244598714780986 243 6710655
SGTC_491 tetrandrine 80.3 µM 1.96863722925133 0.067157144183344 no 353 0.0244973821022726 164 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_668 1682-0499 62.6 µM 1.96504316356525 0.0675359648887137 no 354 0.0247046209900968 256 682214
SGTC_124 0136-0217 7.121 µM 1.96464177689964 0.0675783740315049 no 355 0.0247278565471199 276 3976905
SGTC_2513 baicalein 25.65 µM 1.96415110867131 0.0676302443069671 no 356 0.0247562853551017 222 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1060 3448-7350 82 µM 1.95837115909011 0.0682435808931018 no 357 0.0250932382187778 243 570178
SGTC_3078 9116413 49.47 µM 1.95719770329962 0.0683686242224673 no 358 0.0251621143733882 228 17177322
SGTC_3122 9126309 49.47 µM 1.95464090241688 0.0686416888384127 no 359 0.0253127349862558 187 17591206
SGTC_1246 0422-0085 105 µM 1.9519075539769 0.0689345380492002 no 360 0.025474590639603 279 264295
SGTC_1464 k208-0027 110 µM 1.94682484116906 0.0694816559783814 no 361 0.0257778688620185 226 X1464
SGTC_1594 piperine 70.1 µM 1.94206377482394 0.0699971785185064 no 362 0.0260646901133469 258 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2497 7-hydroxyflavone 100 µM 1.94117847736691 0.0700933611261154 no 363 0.0261183163778138 230 5281894
SGTC_3011 9081274 71.4286 µM 1.938123059996 0.0704260961785838 no 364 0.0263041053497751 268 6625322
SGTC_264 promethazine 12.5 mM 1.9360405655221 0.0706535748872281 no 365 0.0264313664279412 356 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2156 5649887 115 µM 1.93254238282468 0.0710369649456085 no 366 0.0266462980615688 264 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2670 beta-carotene 100 µM 1.92824986963734 0.0715095919493557 no 367 0.0269120269633478 145 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_377 3970-0964 33.1 µM 1.92822824306834 0.0715119792361967 no 368 0.0269133713409316 347 16481235
SGTC_3259 9138485 49.47 µM 1.9234734654045 0.0720383300099709 no 369 0.0272103078903557 258 17646153
SGTC_1503 4585-0012 61.3 µM 1.91979475400998 0.0724475949160948 no 370 0.0274419148891664 216 2922052
SGTC_1991 st073000 8.92 µM 1.91946736543887 0.0724841037731618 no 371 0.0274626062762827 325 4301969 YIL048W NEO1
SGTC_2075 5212009 200 µM 1.91815741932582 0.0726303239248266 no 372 0.0275455267864637 188 780898
SGTC_1378 2093-0007 380 nM 1.91673329615461 0.0727895450477669 no 373 0.0276359114794679 261 3618014
SGTC_202 3594-0513 34.79 µM 1.91347039265384 0.0731553546458232 no 374 0.0278439301494754 183 708429
SGTC_2137 5261020 140 µM 1.91281781317467 0.0732286849400669 no 375 0.0278856899544604 256 763655
SGTC_1195 1502-0147 41.1 µM 1.91031477486998 0.0735104727164492 no 376 0.0280463482796698 267 817940
SGTC_1859 st055998 20 µM 1.90946573298103 0.0736062445006037 no 377 0.0281010190760344 244 676301
SGTC_705 1124-0212 310 µM 1.90587199008178 0.0740126748293103 no 378 0.0283334079555164 259 9554485
SGTC_2791 5663188 71.43 µM 1.89611462052892 0.0751248206169325 no 379 0.0289724448509355 241 54690634
SGTC_889 0919-1524 82.7 µM 1.89604841493743 0.0751324100228124 no 380 0.0289768214144443 233 3905452
SGTC_2776 terbinafine 19.92 µM 1.89502839842441 0.0752494124087426 no 381 0.0290443197371649 266 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_147 4466-0538 29.23 µM 1.89421627146174 0.0753426678264739 no 382 0.0290981546033616 280 6742687 YHR072W ERG7
SGTC_1979 st071809 45.3 µM 1.89206529889171 0.0755900866673352 no 383 0.0292411405464971 229 4976333
SGTC_1463 k081-0032 34.1 µM 1.89003093157502 0.0758246619879071 no 384 0.0293769116727125 166 977755
SGTC_991 3996-0057 64.7 µM 1.88907314124597 0.0759352929959275 no 385 0.0294410144061731 240 715343
SGTC_119 0121-0043 24.815 µM 1.88180133191604 0.0767792468967109 no 386 0.0299314974577947 455 1092378
SGTC_2180 6301957 200 µM 1.88002486151169 0.0769865009681792 no 387 0.0300523448487263 200 845462
SGTC_360 0957-0399 1.01 µM 1.87422117712204 0.0776665590594415 no 388 0.0304499732198335 287 6752301 YPR165W RHO1
SGTC_2204 7233102 200 µM 1.87124597592281 0.0780169475877906 no 389 0.0306554974248271 187 2172480
SGTC_2586 curcumin 80 µM 1.86390779467629 0.0788862886867468 no 390 0.0311673269658052 348 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2164 5685496 200 µM 1.86354440072174 0.0789295292516585 no 391 0.0311928558753293 244 759046
SGTC_2186 6124449 200 µM 1.86331357588885 0.0789570046233543 no 392 0.0312090806082053 253 3834182 YLR033W RSC58
SGTC_2055 5235184 200 µM 1.85760264816282 0.0796390927180647 no 393 0.031612731098958 274 2836034
SGTC_338 4055-0136 114 µM 1.85672127705388 0.0797447557076332 no 394 0.0316754093830642 274 2900563
SGTC_2481 5478948 45.16 µM 1.84760995174616 0.0808432870625699 no 395 0.032329394504015 277 77792
SGTC_572 0960-0087 17.7 µM 1.83122867309848 0.0828470178603716 no 396 0.0335332093460719 345 6796365
SGTC_2995 9067767 71.4286 µM 1.82652423227291 0.0834293069849007 no 397 0.0338856672831054 236 11673567
SGTC_1550 gossypolone 36.6 µM 1.81763676148774 0.0845377341567948 no 398 0.0345598345296899 308 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_930 2810-3379 265 µM 1.81586548944147 0.0847599578246793 no 399 0.0346955041515459 307 1015764
SGTC_582 0987-0078 156 µM 1.81166755835721 0.085288378860632 no 400 0.0350187896181408 409 1625765
SGTC_2303 7774051 200 µM 1.81142543029171 0.0853189322162772 no 401 0.035037511217519 272 2953184
SGTC_1002 4049-0206 172 µM 1.80863228977819 0.0856719826416514 no 402 0.0352540742922995 328 4662749
SGTC_1227 3909-8010 46.6 µM 1.80834365510479 0.0857085280639879 no 403 0.0352765157240925 271 15982272
SGTC_3103 9120822 49.47 µM 1.80640539211485 0.0859542432344808 no 404 0.0354275199726062 274 17141819
SGTC_101 0490-5701 117.494 µM 1.80524389359421 0.0861017397173158 no 405 0.035518262538573 230 4661669
SGTC_2269 7935389 174.42 µM 1.80217011578964 0.086492986401982 no 406 0.0357593224538721 280 97605
SGTC_946 3434-1334 87.4 µM 1.79938961853283 0.0868480463727797 no 407 0.0359785353057829 275 4047976
SGTC_103 0844-0104 51.839 µM 1.79867763086466 0.0869391396468764 no 408 0.0360348446849489 453 5375804
SGTC_1320 1313-0481 95.3 µM 1.78899215332035 0.0881854194975412 no 409 0.036808039628588 287 6813365 YLR208W SEC13
SGTC_2372 9071633 200 µM 1.78815819137034 0.0882933491784783 no 410 0.0368752447015234 275 21321366
SGTC_2213 7173844 200 µM 1.78702415270501 0.0884402720993792 no 411 0.0369667924855147 274 892728
SGTC_1846 st056244 14.8 µM 1.78694422709162 0.0884506339089672 no 412 0.0369732516604418 313 5393182
SGTC_655 k060-0012 42 µM 1.78652080540247 0.0885055427268262 no 413 0.0370074858049824 290 5994525
SGTC_907 3448-6986 75.5 µM 1.78273222832137 0.0889979714478757 no 414 0.0373149512350474 323 590582
SGTC_666 0272-0154 136 µM 1.78056191027142 0.0892809805887146 no 415 0.0374920234699908 338 6870312
SGTC_680 0417-1641 114 µM 1.77554429255994 0.0899378396835963 no 416 0.0379040294480406 257 2835990
SGTC_1518 st038567 90.8 µM 1.77528860949005 0.0899714072065817 no 417 0.0379251225982812 251 77966
SGTC_2283 7944793 200 µM 1.77089429575002 0.0905497734372771 no 418 0.0382891405536435 317 2970533
SGTC_2943 9068529 45.32 µM 1.76752660209284 0.0909948838094611 no 419 0.0385700389658119 326 3270634
SGTC_1409 3909-8004 61.9 µM 1.76500164107878 0.0913296727713829 no 420 0.0387817449527185 327 2119279
SGTC_1632 st005650 90 µM 1.76311108482285 0.0915809421169542 no 421 0.0389408780171645 296 2759605
SGTC_1220 1838-0075 193 µM 1.76229033552193 0.0916901852905923 no 422 0.0390101279609803 304 5529645
SGTC_691 1548-0686 185 µM 1.7558135503136 0.0925556457717123 no 423 0.0395601249560754 346 46495133
SGTC_1130 3454-2858 15.9 µM 1.74765309458636 0.093654671829819 no 424 0.0402620577647316 356 715628 YIL048W NEO1
SGTC_592 k241-0073 46.5 µM 1.74751784623711 0.0936729675012225 no 425 0.0402737760057913 316 4230158
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.74739918302307 0.0936890217977003 no 426 0.0402840595522254 323 4174840
SGTC_934 2950-0684 338 µM 1.7422277820592 0.0943906507307408 no 427 0.0407342972275363 323 1121253
SGTC_76 0433-0009 400.328 µM 1.74001454417772 0.0946921125531726 no 428 0.0409282320733111 242 2841569
SGTC_1271 0832-2808 169 µM 1.73669600416634 0.0951454547073872 no 429 0.0412204217223687 310 3663794
SGTC_2291 7917025 104.35 µM 1.73436952542264 0.0954642241702876 no 430 0.0414262693176737 359 2964612
SGTC_1962 st076595 64.5 µM 1.73385190001362 0.095535254950924 no 431 0.0414721820898492 324 279619
SGTC_879 0831-1030 162 µM 1.73313913202368 0.0956331276783238 no 432 0.0415354712535463 386 1549252
SGTC_2643 anethole 100 µM 1.73169917615601 0.095831078226479 no 433 0.0416635687060101 336 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_271 rotenone 740 µM 1.72910696141938 0.0961881890093553 no 434 0.0418949767403874 346 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.7263768062687 0.0965653595559368 no 435 0.0421398228264626 337 107982 A Capsaicinoid.
SGTC_599 1935-0052 86.5 µM 1.71989976588707 0.0974645058906966 no 436 0.0427253315523698 330 9557311
SGTC_789 1309-1135 70.6 µM 1.71932999007759 0.0975438953721414 no 437 0.0427771510663318 351 3092424
SGTC_3344 9148862 3.898 µM 1.71755612221541 0.0977913601724516 no 438 0.0429388047236011 292 4905352
SGTC_3155 9099265 49.47 µM 1.7156577387609 0.0980567050914178 no 439 0.0431123520040081 286 25236499
SGTC_785 1270-0111 65.3 µM 1.71531369364312 0.0981048501164743 no 440 0.0431438646416459 346 6741994
SGTC_973 1325-0077 65.9 µM 1.71296739518005 0.0984336485709117 no 441 0.0433592690545715 333 2835149
SGTC_2975 9084847 53.72 µM 1.71292988073613 0.0984389122020718 no 442 0.0433627201475239 337 27211724
SGTC_414 piperonyl butoxide 100 µM 1.70997008456203 0.0988548494361932 no 443 0.0436357025502498 284 5794 A potent inhibitor of cytochrome P450.
SGTC_3137 9097352 49.47 µM 1.70881592997494 0.0990173896498821 no 444 0.0437425254950637 368 44120435
SGTC_730 1436-0052 41.2 µM 1.70625945151166 0.0993781158082554 no 445 0.043979892027304 264 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_911 3456-4043 236 µM 1.70466757709928 0.0996032184807438 no 446 0.0441282200581274 361 914281
SGTC_1191 1487-1166 10.6 µM 1.70029420551287 0.100223562657886 no 447 0.0445377999202494 397 3955771
SGTC_1668 st014914 51.6 µM 1.69789972103678 0.10056440255851 no 448 0.04476334496836 287 2839556
SGTC_900 1112-0045 141 µM 1.69558157755616 0.100895180638629 no 449 0.0449825745267069 238 56211 YIL048W NEO1
SGTC_1421 4029-0249 71.4 µM 1.69241179855948 0.101348762317879 no 450 0.0452837421528536 345 2894095
SGTC_2255 7941087 197.44 µM 1.68560668211452 0.102327559404816 no 451 0.0459357906631378 374 935561
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.68153335988549 0.102916714923191 no 452 0.046329681160475 330 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1853 st056710 91.2 µM 1.67905553944822 0.103276304277843 no 453 0.0465706100465104 320 269167
SGTC_311 1315-0136 58 µM 1.6690656237725 0.104735326154938 no 454 0.0475521875522423 314 6759207
SGTC_1253 0550-0034 176 µM 1.66860202724118 0.10480339478815 no 455 0.0475981384296553 327 5969915
SGTC_884 0851-0618 334 µM 1.66770424393105 0.104935304973521 no 456 0.0476872262671547 374 9642473
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.66611926035717 0.10516847797237 no 457 0.0478448315316494 370 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_768 0384-0033 77.3 µM 1.66193769797107 0.105785442526646 no 458 0.0482626335157931 421 3965305 YMR134W ERG29
SGTC_1937 st074714 47.2 µM 1.65722878969577 0.106483340995606 no 459 0.0487366140185301 365 17250970
SGTC_20 0481-0013 4.944 µM 1.65697535729705 0.106520995781189 no 460 0.0487622286811525 342 182045
SGTC_1920 st075728 45.7 µM 1.65565027789803 0.106718031563144 no 461 0.0488963310131173 343 3400306
SGTC_481 bay k-8644 50 µM 1.64844077376326 0.107794675132141 no 462 0.0496311274141134 331 2303 A calcium channel antagonist.
SGTC_1512 0259-0544 12.2 µM 1.64690784883601 0.108024602234489 no 463 0.0497884941884647 386 18476
SGTC_273 hydroxyurea 18.1 mM 1.64529525198591 0.108266860427898 no 464 0.0499544692597094 410 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_160 3453-0671 289.699 µM 1.64476017196653 0.108347331091058 no 465 0.0500096392805592 376 5322268
SGTC_525 k781-2675 26.7 µM 1.64093679305814 0.108923581641784 no 466 0.0504052682297445 392 3651118 YDL195W SEC31
SGTC_872 0588-0139 234 µM 1.6403254955308 0.109015918859681 no 467 0.0504687536329973 371 2047100
SGTC_732 3970-1727 52.7 µM 1.63615098634155 0.109647987660041 no 468 0.0509039957614239 315 1275699
SGTC_334 1502-1024 68.5 µM 1.62937033733324 0.110680256280466 no 469 0.0516173221395863 363 3296216
SGTC_106 0092-0003 11.579 µM 1.62862139924801 0.110794698385971 no 470 0.0516965956518006 267 1072148
SGTC_458 nppb 133 µM 1.62629385220425 0.111150902271133 no 471 0.051943579489052 308 4549 A chloride channel blocker.
SGTC_1004 4084-0029 199 µM 1.62579956855509 0.111226652053618 no 472 0.0519961500913766 382 716894 YLR208W SEC13
SGTC_3012 9080433 71.4286 µM 1.62499856820535 0.111349485141372 no 473 0.0520814319563191 348 17688859
SGTC_2424 5537928 59.2 µM 1.62167776878708 0.111859764113978 no 474 0.0524361806504988 403 5382802
SGTC_2639 lactacystin 53 µM 1.6207788223579 0.111998184738009 no 475 0.0525325409582785 378 3870 A proteasome inhibitor.
SGTC_95 0471-0001 561.058 µM 1.6155655438472 0.112803345097776 no 476 0.053094139301187 379 4015405
SGTC_3164 9100705 49.47 µM 1.61505976585991 0.112881678907306 no 477 0.0531488764058776 279 17174235
SGTC_3003 9075612 71.4286 µM 1.60528883058552 0.114402607494165 no 478 0.0542151280455918 341 6501993
SGTC_2330 7979373 200 µM 1.60099299251857 0.115075887769222 no 479 0.0546892356097114 394 1863007
SGTC_526 4469-0568 170 µM 1.59883960436817 0.115414443230183 no 480 0.0549281232821771 369 2901964
SGTC_3308 9128332 17.569 µM 1.59860290676805 0.115451699935713 no 481 0.0549544317279971 479 17332805 YDL196W YDL196W
SGTC_2006 4011487 200 µM 1.59357548404358 0.116245046225873 no 482 0.0555155745667337 430 45595294
SGTC_2135 5326629 150.42 µM 1.59306932018944 0.116325134620516 no 483 0.0555723204881217 358 5020077
SGTC_1431 4049-0260 9.09 µM 1.58836412105513 0.117071494297422 no 484 0.0561020128617754 368 3854841
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.58494568411383 0.11761586587112 no 485 0.0564893378124715 367 803109
SGTC_1401 3807-4679 7.6 µM 1.58422622180856 0.117730665063965 no 486 0.0565711240769013 339 3291456
SGTC_18 0111-0177 500 nM 1.58184854151874 0.118110617645683 no 487 0.056842075287206 489 721752
SGTC_3303 9125618 40.5795 µM 1.58053536353567 0.118320834447187 no 488 0.0569921574654204 471 22695467
SGTC_2534 helenine 20.12 µM 1.57907058289133 0.118555632105172 no 489 0.0571599341208315 326 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1626 st003712 1.76 µM 1.57676451349509 0.118925951418936 no 490 0.0574248598969445 359 24207035
SGTC_3071 9117417 49.47 µM 1.57521995104747 0.119174440766952 no 491 0.057602841786312 285 45595590 YGL055W OLE1
SGTC_684 1140-0066 328 µM 1.57085349795501 0.119878897988809 no 492 0.0581083410991048 428 6813534
SGTC_2014 4013930 200 µM 1.56905197478857 0.12017039868128 no 493 0.0583179144197365 449 64556
SGTC_3119 9125183 49.47 µM 1.56647850563025 0.120587672111375 no 494 0.0586183183729327 252 22695334
SGTC_505 gw-5074 63.9 µM 1.5645938444311 0.120893905677612 no 495 0.058839086570747 409 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1766 st045414 44.774 µM 1.54800903393483 0.123612336273979 no 496 0.0608100607458946 433 253960
SGTC_1891 st059073 26.2 µM 1.54789284074703 0.123631531395663 no 497 0.060824049302826 407 688754
SGTC_2592 piperlongumine 83.33 µM 1.54734688129152 0.123721751875487 no 498 0.0608898113303656 370 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2474 5321570 43.32 µM 1.53530583863901 0.125723276373634 no 499 0.0623543603206266 368 2841384
SGTC_3278 9139605 49.47 µM 1.5335322918179 0.126019982377654 no 500 0.0625723782675435 388 7958859
SGTC_1596 piperlongumine 63 µM 1.5326320667124 0.126170772438809 no 501 0.0626832679524512 423 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1495 4469-0029 237 µM 1.53190649904823 0.12629239841985 no 502 0.062772754763539 550 793680
SGTC_745 0469-0705 296 µM 1.52882474284494 0.126809899687414 no 503 0.0631539483855552 456 3486736
SGTC_972 1319-0219 195 µM 1.52489052167755 0.127472693332128 no 504 0.063643203190669 413 23903702
SGTC_2097 5376186 200 µM 1.52257356983777 0.127864152694852 no 505 0.0639327131873967 429 742755
SGTC_429 1112-0049 25.5 µM 1.52181878409161 0.127991857324041 no 506 0.0640272467400994 396 2836170
SGTC_2570 licareol 100 µM 1.52167271967651 0.12801658066196 no 507 0.0640455532023327 407 443158
SGTC_244 nsc-207895 1.295 µM 1.52093379987421 0.128141703474766 no 508 0.0641382254533264 319 42640
SGTC_19 0279-0214 38.434 µM 1.52068508791596 0.128183837483139 no 509 0.0641694413108781 506 3566274 YBR002C RER2
SGTC_3094 9117742 49.47 µM 1.51862928139566 0.128532477777144 no 510 0.0644279181868176 446 17149698
SGTC_1750 st081859 2.357 µM 1.51527516588833 0.129102707587232 no 511 0.0648513673354315 627 5291695
SGTC_1502 4534-4282 27.7 µM 1.51471815699348 0.129197573675003 no 512 0.0649218971308413 366 3278949
SGTC_600 1495-0418 41.6 µM 1.5141227132372 0.129299039162955 no 513 0.0649973594762254 396 5377768
SGTC_1236 0330-0013 258 µM 1.51336838012667 0.129427659179691 no 514 0.0650930560761128 374 4617066
SGTC_2837 9008476 45.46 µM 1.50792207408119 0.130358930079862 no 515 0.0657872361631545 449 2992805
SGTC_3232 9132874 49.47 µM 1.50787395078359 0.130367179351064 no 516 0.0657933953802604 384 3784940
SGTC_2067 5224629 34.075 µM 1.50110841711821 0.131530519069862 no 517 0.0666637610548302 436 2835000
SGTC_708 3448-5400 146 µM 1.50023086169812 0.13168193890438 no 518 0.0667773057936411 444 3462195
SGTC_24 0417-1663 219 µM 1.49884065781112 0.13192206099884 no 519 0.0669574870847053 414 4329390
SGTC_1709 st033179 39.1045 µM 1.49801395027092 0.132064996657106 no 520 0.0670648130171983 448 573381
SGTC_637 1181-0519 7.26 µM 1.49759509209461 0.132137456930991 no 521 0.0671192413403922 551 6252091 YGR060W ERG25
SGTC_2587 piperic acid 92.2 µM 1.49716396946086 0.132212067514696 no 522 0.067175299029858 394 5370536
SGTC_2922 7999257 32.47 µM 1.49716096398583 0.132212587747614 no 523 0.0671756899505305 367 2988377
SGTC_2468 5987765 72.9 µM 1.49673786927796 0.132285837439796 no 524 0.06723073922853 417 26772094
SGTC_407 eburnamonine 100 µM 1.49625055563843 0.1323702399091 no 525 0.067294187309857 357 3195
SGTC_2886 9058944 51.95 µM 1.49551693695951 0.132497372263364 no 526 0.0673897915130874 229 4949929
SGTC_2991 9074669 71.4286 µM 1.49497567720607 0.132591223720217 no 527 0.0674603950345146 493 17333109
SGTC_1159 4092-0538 61.2 µM 1.49465825701041 0.132646283931172 no 528 0.0675018268478543 464 717301
SGTC_3321 9137793 26.8275 µM 1.49462788237397 0.132651553589391 no 529 0.0675057925798263 451 4904192
SGTC_1491 4138-0063 26.5 µM 1.49304032198801 0.132927178235338 no 530 0.0677133162076365 374 23883227
SGTC_1555 citronellol 128 µM 1.49236194736971 0.133045074549647 no 531 0.0678021425115451 372 8842 A terpine precursor.
SGTC_2949 9072542 2.23 µM 1.49196795547317 0.13311358035563 no 532 0.0678537730689789 479 16457352
SGTC_3001 9076041 71.4286 µM 1.48976769587141 0.133496599425399 no 533 0.0681426639116669 425 16004211
SGTC_1199 1638-0010 4.46 µM 1.48936209330099 0.133567288990795 no 534 0.0681960224216379 468 3111136
SGTC_1737 st035557 69.7 µM 1.48502104357137 0.134325471570244 no 535 0.0687691248785841 356 5716916
SGTC_2966 9084041 48.03 µM 1.48422098732797 0.134465526661043 no 536 0.0688751518753972 428 17741380
SGTC_694 1315-0438 43.2 µM 1.48203338831515 0.134848991919838 no 537 0.0691657055886698 370 6793154
SGTC_3261 9137475 49.47 µM 1.47878215387087 0.135420287250831 no 538 0.0695992734988443 223 17027690
SGTC_1125 tnp00248 1.32998 µM 1.47329184452912 0.136388785843723 no 539 0.0703361794067702 544 24207736
SGTC_998 3996-0085 177 µM 1.47040124492608 0.13690059140689 no 540 0.0707265572043326 476 715391
SGTC_2315 7733312 200 µM 1.46806707344311 0.137314833345285 no 541 0.0710430022212983 401 726316
SGTC_1897 st060201 15 µM 1.46695060595369 0.13751327350149 no 542 0.0711947462958847 403 611878
SGTC_2576 guaiol 23.12 µM 1.46314894431334 0.138190445985881 no 543 0.07171331382535 467 227829
SGTC_417 st075190 100 µM 1.46309474352521 0.138200116933029 no 544 0.0717207280036335 458 222757
SGTC_3236 9132701 49.47 µM 1.45675323180353 0.139334807429765 no 545 0.0725922549626991 432 24282524
SGTC_2589 lobaric acid 100 µM 1.44812615447799 0.140888606818468 no 546 0.0737908860677401 446 73157 A novel microtubule depolymerizer.
SGTC_661 1304-0007 33.6 µM 1.44583816264982 0.141302655374819 no 547 0.0741112997130533 432 3117130
SGTC_2016 5121758 140 µM 1.44422714866767 0.141594688388258 no 548 0.0743375452732207 512 2795203
SGTC_3322 9139058 2.11 µM 1.44347878604826 0.141730485168113 no 549 0.0744428221122021 442 4908926 YPR165W RHO1
SGTC_1994 st072947 40.9 µM 1.44128647396399 0.142128806478476 no 550 0.074751883483453 455 5286565 YDL195W SEC31
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.43524641449293 0.143230141475764 no 551 0.0756084457774249 562 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1330 1469-0054 61.8 µM 1.4347337153485 0.143323890918888 no 552 0.0756814963842543 454 7102664
SGTC_1631 benzylvanillin 81.9 µM 1.4306927503574 0.144064250574365 no 553 0.0762591459405689 482 75506
SGTC_2141 5621638 7.665 µM 1.42651057875357 0.144833192406682 no 554 0.076860507758833 438 2856238
SGTC_150 3970-0969 77.2 µM 1.42361930654717 0.145366399941452 no 555 0.0772783519750244 555 6615640
SGTC_993 3909-8757 62.7 µM 1.42138176411047 0.145779952124068 no 556 0.077602902495088 419 4288324 YLR208W SEC13
SGTC_1483 3453-0561 55.9 µM 1.42121455021325 0.145810889038905 no 557 0.0776271979928704 517 4546991
SGTC_803 4488-1585 147 µM 1.4187673848761 0.146264153776118 no 558 0.0779834221454903 433 747204
SGTC_3277 9138724 49.47 µM 1.41863949585065 0.146287867410362 no 559 0.0780020724904198 352 15943418
SGTC_306 1672-3436 11.6 µM 1.41689756213226 0.146611119972148 no 560 0.0782564396926606 473 6797378
SGTC_3244 9134489 49.47 µM 1.4129790644755 0.147340030761579 no 561 0.0788309399246806 471 16584271
SGTC_325 2810-4341 181 µM 1.41181473625789 0.147557083915968 no 562 0.0790022591418527 447 774970
SGTC_1051 3253-3903 78 µM 1.41076656635312 0.147752666050767 no 563 0.0791567278957249 507 5509239
SGTC_2716 st080858 38.6235 µM 1.41071029798993 0.147763170292866 no 564 0.0791650266253802 444 5296050
SGTC_2409 alverine citrate 63.97 µM 1.40500011657147 0.148831754095694 no 565 0.0800106218040525 500 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_368 fentichlor 4.58 µM 1.40389826431574 0.149038543866112 no 566 0.0801745733058316 415 7329 A pesticide.
SGTC_1118 chelidonine 707.474 nM 1.401904675977 0.149413177485605 no 567 0.0804718569871481 514 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_509 pifithrin 175 µM 1.40188567579176 0.149416751007557 no 568 0.0804746942935525 439 4817 A p53 inhibitor.
SGTC_1783 st039459 87.517 µM 1.40177925063204 0.149436768322145 no 569 0.0804905882088821 531 729761
SGTC_245 methotrexate 289.6 µM 1.40041606451018 0.149693325822909 no 570 0.0806943810908866 522 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.39659861716424 0.150413348778036 no 571 0.0812671531873426 522 2333 A French combination drug.
SGTC_413 propylparaben 100 µM 1.39228635244129 0.151229472095955 no 572 0.0819178512828952 465 7175 A pharmaceutical preservative.
SGTC_2150 5556613 200 µM 1.39052159056488 0.151564312255726 no 573 0.0821852738694368 523 743190
SGTC_1297 1068-0111 14.1 µM 1.38916056462769 0.151822885242922 no 574 0.0823919651926535 458 767057
SGTC_1482 3346-2049 8.48 µM 1.38822525495718 0.152000748829023 no 575 0.0825342321358701 468 3826804
SGTC_2246 7293507 91.5585 µM 1.3881121113386 0.15202227421653 no 576 0.0825514545777434 497 887656
SGTC_1943 st076331 65.2 µM 1.38532149579412 0.152553825028434 no 577 0.0829770918437857 494 24208415
SGTC_2415 st077333 57.7 µM 1.38372963265092 0.152857591611157 no 578 0.0832206282496283 571 2766255
SGTC_463 ikarugamyin 104 µM 1.38296318033314 0.153003992492093 no 579 0.0833380779708642 378 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_696 1560-0013 611 µM 1.37706991138847 0.154132776466848 no 580 0.0842453171001607 506 1650269
SGTC_2767 sibutramine 71.45 µM 1.37469275935324 0.154589646218023 no 581 0.084613358480654 501 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2512 diallyl trisulfide 49.23 µM 1.36969097812561 0.155553868811237 no 582 0.0853916930724734 439 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2802 7925815 54.55 µM 1.36948978947998 0.155592735942617 no 583 0.0854231121590797 527 1262923
SGTC_901 1112-0062 60.1 µM 1.36916068862295 0.155656327922675 no 584 0.0854745256149572 466 1908457
SGTC_412 gemfibrozil 100 µM 1.36833046301606 0.155816828122796 no 585 0.0856043297610086 424 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3085 9117376 49.47 µM 1.36717902183046 0.156039606644413 no 586 0.0857845995648382 493 16480349
SGTC_126 0417-1624 672.48 µM 1.36714389560854 0.156046406093013 no 587 0.0857901033945137 626 41912 YDL195W SEC31
SGTC_302 1094-0063 18.9 µM 1.36557407945313 0.156350477705219 no 588 0.0860363434529565 436 5440289
SGTC_1812 st052057 4.327 µM 1.36338058624705 0.156776008045072 no 589 0.0863812981401504 521 3645418
SGTC_1479 0549-0158 134 µM 1.36315566157433 0.156819685722385 no 590 0.086416728782117 553 5440202
SGTC_881 0833-0569 170 µM 1.36044670745785 0.157346361081934 no 591 0.0868443032211032 510 5418700
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.35993491119794 0.157445995044878 no 592 0.0869252610649749 591 91467 include heat shock
SGTC_3248 9135562 49.47 µM 1.35771215192932 0.157879191814292 no 593 0.087277519664268 536 17650701
SGTC_652 0437-0092 114 µM 1.35631065821576 0.158152732904764 no 594 0.0875001728731748 478 3091274
SGTC_3165 9101544 49.47 µM 1.35502536034392 0.158403868373537 no 595 0.087704738620397 518 5002184
SGTC_2805 7950783 58.44 µM 1.35424406631782 0.15855665386581 no 596 0.0878292622429914 574 1178958 YDL195W SEC31
SGTC_319 1348-1596 45.5 µM 1.35415204847212 0.158574654720675 no 597 0.0878439368386314 529 5380505
SGTC_2198 6589944 200 µM 1.35302700456757 0.158794848125314 no 598 0.0880235017108361 395 5290268
SGTC_1747 st037496 66.6 µM 1.3522510176742 0.158946840888759 no 599 0.0881475140376506 542 723305
SGTC_2306 7482397 179.52 µM 1.35007545413116 0.159373477260401 no 600 0.0884958904691281 525 891448
SGTC_2161 5662504 8.5105 µM 1.34808830622049 0.159763819198932 no 601 0.0888149910395802 488 2859334
SGTC_3139 9095020 49.47 µM 1.34778089560764 0.15982426068615 no 602 0.0888644321355665 369 25236292
SGTC_608 k048-0125 159 µM 1.34614455592199 0.160146241039267 no 603 0.0891279508512634 527 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_561 1550-0330 72.9 µM 1.34411925605836 0.160545343400869 no 604 0.0894549131050061 480 6812934
SGTC_488 nitrendipine 139 µM 1.34369191641104 0.160629637208494 no 605 0.0895240161975648 546 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2277 7947813 106.88 µM 1.3417777767677 0.161007560663598 no 606 0.0898340299575379 502 1246798
SGTC_3117 9124945 49.47 µM 1.34155023931717 0.161052523709864 no 607 0.0898709348878837 435 17592065
SGTC_2640 pentamidine 10.38 µM 1.3397915312669 0.161400333552073 no 608 0.0901565648442939 580 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1115 galangin 695.678 nM 1.3377544379237 0.161803809922317 no 609 0.0904882493691041 563 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2843 9000894 45.46 µM 1.33741164661051 0.161871769344697 no 610 0.0905441524290791 375 2242070
SGTC_1091 telmisartan 47.6 µM 1.33473504053729 0.162403054083506 no 611 0.090981540393558 528 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2667 digitoxin 100 µM 1.33429121047339 0.162491260349094 no 612 0.0910542185285268 416 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2202 7226349 200 µM 1.33146329913921 0.163054008105048 no 613 0.0915183066777951 453 844334
SGTC_2086 5274770 176.623 µM 1.32996697054024 0.163352285888025 no 614 0.0917645770335968 511 689278
SGTC_606 k015-0008 38.6 µM 1.32979615578646 0.163386358587493 no 615 0.091792721440331 569 1970475
SGTC_114 0364-0001 490.298 µM 1.32684138260395 0.163976482596724 no 616 0.0922805790297413 548 4003655
SGTC_446 go6976 132 µM 1.32572042859748 0.164200719664075 no 617 0.0924661590897844 479 3501 A protein kinase C inhibitor.
SGTC_2021 4019055 173 µM 1.32025954468246 0.165295964544683 no 618 0.0933741887936208 705 44827708 YER133W GLC7
SGTC_975 1335-0046 28.5 µM 1.31814970539473 0.165720380932495 no 619 0.0937267690377826 525 16486740
SGTC_2187 6125751 200 µM 1.31766621680792 0.165817738895577 no 620 0.0938077042095979 544 874498
SGTC_2532 xanthone 78.9 µM 1.31513627846797 0.166327784187544 no 621 0.0942320530058504 483 7020 An insecticide.
SGTC_1104 tacrolimus 29.8 µM 1.31247467210595 0.166865466660395 no 622 0.0946800132029339 576 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_692 k241-0027 77.8 µM 1.31128668991907 0.167105817525271 no 623 0.0948804617426813 514 3600480
SGTC_2266 7929956 200 µM 1.31050749906671 0.167263583464689 no 624 0.0950121045041469 557 2967153
SGTC_2028 5153890 36.43 µM 1.30976855880633 0.167413288368222 no 625 0.0951370712582676 531 2830968 YPR165W RHO1
SGTC_828 2074-0507 139 µM 1.30868165367552 0.167633645729699 no 626 0.0953211044110759 571 X828
SGTC_2053 5265679 138 µM 1.30575252273165 0.168228422551199 no 627 0.095818365150022 574 764595
SGTC_2906 7926292 26.41 µM 1.3011119105713 0.169173500982965 no 628 0.0966100757253825 542 2966319
SGTC_128 0906-2981 13.371 µM 1.29972015868954 0.169457599796663 no 629 0.0968484493204594 484 6740226
SGTC_443 clozapine 122 µM 1.2969712608321 0.170019632271858 no 630 0.0973205377047364 456 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_307 1501-1223 22.3 µM 1.29695436981187 0.170023089455045 no 631 0.0973234437331067 553 2830329
SGTC_500 h-89 112 µM 1.29602857824122 0.170212645505672 no 632 0.097482819630025 587 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_269 exalamide 29 µM 1.29601203077888 0.170216034833919 no 633 0.0974856700316599 527 3316 A derivative of salicylamide.
SGTC_2531 methyl deoxycholate 70.07 µM 1.29531585721111 0.170358667521702 no 634 0.0976056455803185 528 16667744 Haematoxylin.
SGTC_1877 wortmannin 25 µM 1.28766877047776 0.171930446343156 no 635 0.0989306445105766 614 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1905 st060207 84.5 µM 1.28355144168753 0.172780542688331 no 636 0.0996494746869666 563 1948547
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.27947045822457 0.173625773849691 no 637 0.100365718076172 542 140250 A respiratory chain inhibitor.
SGTC_1129 3453-1384 223 µM 1.27758219929857 0.174017748554795 no 638 0.100698390154396 613 1084452
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.27613989259287 0.174317528833873 no 639 0.100953035925375 538 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_995 3931-2021 34.6 µM 1.27467705675165 0.17462191100293 no 640 0.101211785401982 538 730143
SGTC_11 0438-0307 1.3 µM 1.27417776502338 0.174725879223368 no 641 0.101300211699724 537 4011476
SGTC_2601 securinine 100 µM 1.26710673438279 0.176202507106145 no 642 0.102558563952921 563 442872 A GABA receptor antagonist.
SGTC_633 0437-0093 97.7 µM 1.26554562427025 0.176529571601474 no 643 0.102837902084634 542 2831118
SGTC_3283 9109332 35.8195 µM 1.26432113597434 0.176786379779547 no 644 0.103057393164725 478 17027281
SGTC_706 4262-0057 46.9 µM 1.26428745077437 0.17679344780944 no 645 0.10306343608488 565 883298
SGTC_2897 9048598 12.99 µM 1.26076446010167 0.177533648887815 no 646 0.103696860963151 547 6467404
SGTC_2770 toltrazuril 17.5 µM 1.25633469334211 0.178467140564861 no 647 0.104497324224817 619 68591 Kills coccidiodes.
SGTC_205 1486-1330 71.903 µM 1.25525568508633 0.178694989121679 no 648 0.104692978330389 524 4118834
SGTC_265 mycophenolic acid 32.932 µM 1.2514649640104 0.179496907106183 no 649 0.105382444268062 628 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_977 1348-1378 135 µM 1.24470270514378 0.180933053637398 no 650 0.106620525622439 600 X977
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.24336896546328 0.181217156829831 no 651 0.106865950522164 613 5393153
SGTC_2692 st077426 47.7 µM 1.23965668019566 0.182009389979201 no 652 0.107551203221304 606 25238571
SGTC_3203 9113543 49.47 µM 1.23460839759284 0.183090205222247 no 653 0.108488141076153 570 17018012
SGTC_2920 7982904 15.77 µM 1.23295617637005 0.183444806436429 no 654 0.108796057383782 520 6456808
SGTC_1388 3346-4487 254 µM 1.22962026691596 0.184162066086398 no 655 0.10941966851363 636 3345614
SGTC_1657 st012939 43.4 µM 1.22944878800029 0.184198983173598 no 656 0.109451793824133 551 24207257
SGTC_2800 7887935 81.82 µM 1.22900867520904 0.184293754573167 no 657 0.109534276713601 584 2961002
SGTC_924 2046-0044 21.3 µM 1.22707017287311 0.184711541734 no 658 0.109898108667156 597 3623589
SGTC_623 k072-0108 16.9 µM 1.22652687094684 0.184828740041263 no 659 0.110000234873483 604 5382803
SGTC_442 cape 100 µM 1.22535793843491 0.185081052825635 no 660 0.110220193690615 543 5281787
SGTC_955 1216-0110 33 µM 1.2238765107412 0.185401124596905 no 661 0.11049940793797 639 3619719
SGTC_2281 7943571 200 µM 1.22387297565988 0.185401888784183 no 662 0.110500074823461 636 1244024
SGTC_3336 9143619 71.43 µM 1.22337842653414 0.185508815963633 no 663 0.110593398891082 648 45595730
SGTC_1356 1502-0781 85.8 µM 1.22084600771069 0.186056953470976 no 664 0.111072165218772 596 567702
SGTC_2177 5811945 192 µM 1.21890261476931 0.186478277536512 no 665 0.111440578567956 602 5343475
SGTC_2504 purpurogallin 52.29 µM 1.21816323482889 0.186638728821831 no 666 0.111580973886877 568 5281571 An antioxidant.
SGTC_2309 7664088 163.95 µM 1.21733534330454 0.186818489224152 no 667 0.111738326141426 669 704922
SGTC_373 0844-0104 25.9 µM 1.21724632505626 0.186837824168559 no 668 0.111755254739152 646 5375804
SGTC_3131 9127911 49.47 µM 1.21724137375193 0.186838899638277 no 669 0.111756196382409 588 45595681
SGTC_2467 5474540 200 µM 1.21508888588969 0.187306802996386 no 670 0.112166096020732 603 5413519
SGTC_426 0988-0037 14.6 µM 1.21438795110202 0.187459326982751 no 671 0.112299807136326 667 5383008
SGTC_60 0986-0278 202 µM 1.21223246325992 0.187928843700061 no 672 0.112711704039298 469 3110598
SGTC_1615 st002656 86.5 µM 1.21051638781329 0.188303164563152 no 673 0.113040403148427 613 1584458
SGTC_405 ebelactone b 50 µM 1.21003647563807 0.188407928187354 no 674 0.113132448376849 628 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1222 0366-0074 1.18 µM 1.20826492657669 0.188794964101588 no 675 0.113472687419421 643 286520
SGTC_2337 9009472 200 µM 1.20349629585903 0.18983921407947 no 676 0.114392161958987 668 5742383
SGTC_1264 0783-0040 158 µM 1.20286480533616 0.189977765698046 no 677 0.114514320863093 571 2855798
SGTC_2739 tacrine 100.86 µM 1.20213734543198 0.190137450417451 no 678 0.114655159658521 573 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1767 st044992 70.3 µM 1.19621926558793 0.191439590745494 no 679 0.115805502300368 615 9600693
SGTC_2114 5491910 81.25 µM 1.19596677958338 0.191495265874868 no 680 0.11585476159278 639 2849228
SGTC_1900 st060200 72.8 µM 1.1922060367671 0.192325712813675 no 681 0.116590233480302 624 688945
SGTC_2998 9066762 71.4286 µM 1.19152214350809 0.192476966404171 no 682 0.116724334490266 674 4945196
SGTC_1743 st037606 46.3785 µM 1.18968935940206 0.192882673460743 no 683 0.117084254552224 609 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2600 tangeritin 87.95 µM 1.18614815160115 0.193668037246545 no 684 0.117781898822506 596 68077 A bioactive flavone.
SGTC_1335 1486-0900 202 µM 1.1855330594427 0.193804649957749 no 685 0.117903375781886 659 X1335
SGTC_903 1134-0042 114 µM 1.18546497234458 0.193819775794788 no 686 0.117916828016692 615 701009
SGTC_758 0868-0029 16 µM 1.1841991448704 0.194101115759356 no 687 0.11816712028476 636 762687
SGTC_2717 st081029 62.2815 µM 1.183218054445 0.19431934174764 no 688 0.118361369721682 608 5292846
SGTC_1357 1503-1303 39.5 µM 1.18168781834072 0.1946600134316 no 689 0.11866479681176 674 292895
SGTC_3007 9078383 71.4286 µM 1.18153052524214 0.194695051687075 no 690 0.11869601722916 644 6496995
SGTC_272 doxorubicin 8.13 µM 1.18111133150832 0.194788449073881 no 691 0.118779249495292 701 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_478 N-arachidonylglycine 10 µM 1.18026082299037 0.194978028167324 no 692 0.118948247363245 497 5283389
SGTC_3319 9138450 16.7555 µM 1.17934833109016 0.195181548107366 no 693 0.119129750197503 613 2029690
SGTC_786 4544-0069 423 µM 1.17867063678584 0.195332782887009 no 694 0.119264676146275 673 748821 YLR208W SEC13
SGTC_913 3487-1245 167 µM 1.17520797399804 0.196106623950244 no 695 0.119955760408559 642 4016153
SGTC_1732 st034308 51.822 µM 1.17287101494943 0.196629940403737 no 696 0.120423767288683 617 830119
SGTC_2166 5933061 31.504 µM 1.17206477499144 0.19681067822904 no 697 0.120585525453063 637 2877375
SGTC_2957 9076800 11.52 µM 1.17183359355509 0.196862521588582 no 698 0.120631936237865 580 16459615
SGTC_2469 5655019 90.81 µM 1.1716460818276 0.196904577914321 no 699 0.120669589354645 677 2788239
SGTC_3161 9100388 49.47 µM 1.17076529659582 0.197102198814165 no 700 0.120846565316394 641 25236368
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.16997104470173 0.197280507192726 no 701 0.121006310717853 711 688788
SGTC_2363 9053361 176 µM 1.16397590979491 0.198629551516699 no 702 0.122216887289735 661 6469797 YMR079W SEC14
SGTC_1884 5633444 25 µM 1.16388750250906 0.198649486741245 no 703 0.122234802450848 666 5724239
SGTC_945 3381-0768 11.3 µM 1.16257075608002 0.198946546646598 no 704 0.122501850775998 691 1126236 YIL048W NEO1
SGTC_2235 salicylic acid 500 µM 1.15935508951004 0.199673130060267 no 705 0.123155737485274 637 338 A COX inhibitor and kinase inhibitor.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.15702260361108 0.200201155529222 no 706 0.12363156276587 633 115019
SGTC_1876 myriocin 605 nM 1.15525978646114 0.200600776244537 no 707 0.123992029163053 656 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1983 st071813 46.9 µM 1.15240867453024 0.201248120089977 no 708 0.124576589036889 664 11838595
SGTC_3213 9129884 49.47 µM 1.14527433353027 0.202873448197624 no 709 0.126047767315012 563 17190742
SGTC_1845 st056753 3.01 µM 1.1437247779536 0.203227497853487 no 710 0.126368897090141 672 5375839
SGTC_2074 5212007 75.395 µM 1.14323153357625 0.203340273952436 no 711 0.126471236523776 596 758611
SGTC_656 4090-1979 187 µM 1.13965692401261 0.204158693163242 no 712 0.127214629939265 730 22330961
SGTC_899 1083-0020 478 µM 1.13719152017051 0.20472429735516 no 713 0.127729115551624 693 767123
SGTC_2616 abietic acid 100 µM 1.13626016394523 0.204938208120041 no 714 0.127923848765521 727 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_829 1635-0120 117 µM 1.1361267885856 0.204968852197717 no 715 0.127951752514875 708 285054
SGTC_1731 st035964 63 µM 1.13453534623346 0.205334709193833 no 716 0.128285027924703 651 6739575
SGTC_1015 4130-4525 82 µM 1.1344959710175 0.205343766084607 no 717 0.128293281406597 680 1363237
SGTC_1892 st058411 7.36 µM 1.13367513789967 0.20553262405056 no 718 0.128465421092447 741 3934738
SGTC_1012 4112-3522 18 µM 1.133370646782 0.205602707834796 no 719 0.128529317702595 673 3112398
SGTC_3021 9087658 49.47 µM 1.13178449233187 0.205968017490816 no 720 0.128862524497112 635 25237042
SGTC_218 alverine citrate 93.75 µM 1.12810749458728 0.206816351736339 no 721 0.129637262194102 652 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1730 st033808 45.1 µM 1.12467013516398 0.207611265601764 no 722 0.1303644207603 769 1045166
SGTC_1774 st048371 48.465 µM 1.1240439339344 0.207756273254898 no 723 0.130497194154619 700 4242727
SGTC_2840 9008771 71.43 µM 1.12256347176218 0.208099337529182 no 724 0.130811468238201 626 2992978
SGTC_2432 5630864 12.22 µM 1.12194117874476 0.208243639884553 no 725 0.130943725291334 667 5714970
SGTC_2978 9011784 42.97 µM 1.12096710137109 0.208469635348131 no 726 0.13115093316758 800 2994934
SGTC_2271 7849410 118.62 µM 1.117552879466 0.209262909264115 no 727 0.131879001586839 703 972430
SGTC_1119 parthenolide 318.541 nM 1.11689497010609 0.209415974469858 no 728 0.132019617758707 760 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1166 k206-0078 225 µM 1.11675158545027 0.209449342216286 no 729 0.132050277341624 723 5404595
SGTC_247 mechlorethamine 29.705 µM 1.1142595944694 0.210029765111816 no 730 0.132583917862331 634 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1193 1488-0126 41.5 µM 1.11413372182265 0.210059107832706 no 731 0.13261091187332 700 1384710
SGTC_908 3448-7491 47.7 µM 1.113599262447 0.210183724807006 no 732 0.132725571493133 763 1203031
SGTC_1665 st014639 11.4 µM 1.11235064300975 0.210475027748135 no 733 0.132993708650103 741 981133 YIL048W NEO1
SGTC_462 ag-879 158 µM 1.1101800897995 0.210981981493637 no 734 0.133460715303779 734 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3176 9106582 49.47 µM 1.1101708486099 0.210984141392296 no 735 0.133462706005705 532 17018027
SGTC_1677 st019204 53.9 µM 1.10916240689907 0.211219917488289 no 736 0.133680063409777 659 3945625
SGTC_2857 9024691 58.44 µM 1.10826716802163 0.211429355789966 no 737 0.133873225140171 647 16478292
SGTC_611 3453-1652 23.7 µM 1.10820381044914 0.211444182700293 no 738 0.133886902787943 728 1560575
SGTC_3055 9094636 49.47 µM 1.10760053944378 0.211585390405369 no 739 0.134017185185043 660 25236176
SGTC_935 2996-0153 430 µM 1.10538843305366 0.212103650514602 no 740 0.134495656828 707 23738523
SGTC_2946 9065502 71.43 µM 1.1051191971802 0.212166778675043 no 741 0.134553971651177 532 16489101
SGTC_2192 5915882 198.485 µM 1.1006378188317 0.213219146516521 no 742 0.13552715946715 649 2876149
SGTC_1405 3909-7894 12 µM 1.09632785121367 0.214234127523663 no 743 0.136467662644581 710 7104060
SGTC_2436 5633522 8.09 µM 1.09419076039338 0.214738444936907 no 744 0.136935661469326 723 5724242
SGTC_1947 st076332 61.6 µM 1.09355536578743 0.214888520289023 no 745 0.137075017016914 654 24208416
SGTC_421 streptovitacin 30 mM 1.09242372846465 0.215155955200198 no 746 0.137323449031093 747 91467 include heat shock
SGTC_3068 9116768 49.47 µM 1.09177834199858 0.215308563041961 no 747 0.137465270420403 646 41904888
SGTC_1416 3966-0321 25.3 µM 1.09079079427283 0.215542199753859 no 748 0.137682474049335 733 582530 YLR208W SEC13
SGTC_1152 3909-8331 15.9 µM 1.09073140326524 0.215556255324651 no 749 0.137695544113109 677 16001939
SGTC_2365 9042475 200 µM 1.08839000417329 0.216110797985163 no 750 0.138211486021352 699 6464479
SGTC_2712 st079126 47.7 µM 1.08367975360115 0.217228884729279 no 751 0.139253407787737 668 3152970
SGTC_433 pimozide 108 µM 1.08353509188901 0.217263276328556 no 752 0.139285491770961 583 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2196 6573537 42.6665 µM 1.08216248500311 0.21758975371237 no 753 0.139590167424019 716 2903087
SGTC_3040 9091894 49.47 µM 1.07975816327927 0.218162308390041 no 754 0.140124942912674 649 25236966
SGTC_502 l-744,832 89.3 µM 1.0775075871336 0.218699036664828 no 755 0.140626781530069 732 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_926 2268-1401 59.4 µM 1.07448140837323 0.21942193104597 no 756 0.141303486518428 730 2931578
SGTC_2795 7780010 54.55 µM 1.07158029342342 0.220116237312679 no 757 0.141954294294618 677 953673
SGTC_2428 5615643 7.78 µM 1.0705866678443 0.220354325098985 no 758 0.142177660369369 697 2253075
SGTC_793 0488-0545 106 µM 1.07036062588939 0.220408508790762 no 759 0.142228507575419 742 292548
SGTC_1721 st082152 9.2685 µM 1.06918296847804 0.220690924254101 no 760 0.142493615796946 680 5296051
SGTC_1256 0570-0116 285 µM 1.06882156738984 0.220777633836497 no 761 0.142575039541481 692 410638
SGTC_1669 st015249 58.4 µM 1.06848281968817 0.22085892598894 no 762 0.142651388034949 747 722793
SGTC_613 3914-0030 117 µM 1.06768399834787 0.221050693747661 no 763 0.142831539451954 488 1145395
SGTC_2727 riluzole 51.77 µM 1.06766692104957 0.221054794421832 no 764 0.14283539242866 676 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1849 st056239 19.2 µM 1.06627031938843 0.221390299735429 no 765 0.143150731235981 729 5393181
SGTC_3204 9114183 49.47 µM 1.06583305777331 0.221495402819343 no 766 0.143249557168392 700 17027248
SGTC_1240 0356-0016 42.1 µM 1.06565916557429 0.221537208620411 no 767 0.143288871520312 731 4305613
SGTC_3246 9135460 32.98 µM 1.06199375874812 0.222419465910885 no 768 0.144119259287395 662 41446951
SGTC_427 1354-0053 47.3 µM 1.06081948104786 0.222702535862134 no 769 0.144385973569794 723 6813657
SGTC_875 0709-0210 25.7 µM 1.06049979275665 0.222779635076441 no 770 0.144458642103409 798 6251364
SGTC_3287 9117173 37.0625 µM 1.06031185371059 0.222824967428151 no 771 0.144501374139522 696 2789709
SGTC_2451 5856223 45.7 µM 1.0602875361093 0.222830833405702 no 772 0.144506903898147 721 2179896
SGTC_1655 st012546 55.1 µM 1.05958036356433 0.223001458541402 no 773 0.144667775439831 712 720985 YLR208W SEC13
SGTC_1927 st060202 13.8 µM 1.05872183679385 0.223208702081551 no 774 0.144863239945593 740 688887
SGTC_787 4152-0075 138 µM 1.05870861989921 0.223211893422357 no 775 0.144866250482411 718 9566539
SGTC_2556 citropten 84.59 µM 1.05708816679906 0.223603363492513 no 776 0.145235675597778 795 2775 A potential DNA crosslinker.
SGTC_596 1155-0152 116 µM 1.05697503064163 0.223630709569746 no 777 0.145261491627161 786 280313
SGTC_1197 1601-0112 267 µM 1.05677865480926 0.223678179977251 no 778 0.145306309072649 760 7350313
SGTC_1554 st069299 38.7 µM 1.05456706277392 0.224213188947337 no 779 0.145811687146809 729 24207999
SGTC_2954 9074818 52.69 µM 1.05180201947344 0.224883105017264 no 780 0.146445196166034 724 16648742
SGTC_391 gliotoxin 8.33 µM 1.05055259772024 0.225186187353285 no 781 0.146732060882202 799 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3157 9099274 49.47 µM 1.04920993812658 0.225512144922534 no 782 0.147040752825817 730 17217662
SGTC_232 clozapine 119 µM 1.04670476907006 0.226121038411657 no 783 0.147617881752038 747 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1493 4348-0038 111 µM 1.04554286280056 0.226403760459843 no 784 0.14788607055578 810 800424
SGTC_110 0850-0284 111.64 µM 1.04462727903949 0.226626686392719 no 785 0.14809763336387 624 3906265
SGTC_1806 st050005 60.3 µM 1.04419632932425 0.226731656706384 no 786 0.148197282449666 730 5194765
SGTC_1323 1348-1351 11.2 µM 1.04356819766777 0.226884705532228 no 787 0.148342606512794 726 6989654
SGTC_2772 vinpocetine 57.06 µM 1.04264232421999 0.227110407519903 no 788 0.148556989641867 738 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1509 1326-1131 80 µM 1.04211298622917 0.227239502128624 no 789 0.148679649240946 734 768313
SGTC_1037 k284-1091 78.7 µM 1.04022963689128 0.227699147316339 no 790 0.149116612738787 710 3334711
SGTC_2844 9010103 25.97 µM 1.0395290501318 0.227870264101895 no 791 0.149279377366533 734 2480525
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.03768116889596 0.228321951996036 no 792 0.14970925739881 733 616764
SGTC_577 r071-0003 38.6 µM 1.0248115128556 0.231481672787267 no 793 0.152726066526414 908 4568517 YMR134W ERG29
SGTC_378 3970-0959 8.33 µM 1.02276901047595 0.231985374150745 no 794 0.153208536755271 779 6615653
SGTC_354 2783-3500 4.88 µM 1.02170296962014 0.232248512605809 no 795 0.153460752585349 757 6740761
SGTC_447 ml7 120 µM 1.02130513452874 0.232346755612973 no 796 0.153554947272384 803 4216 Selective myosin light chain kinase inhibitor.
SGTC_164 4100-3994 89.624 µM 1.02069436562699 0.232497626337001 no 797 0.153699632404799 848 4615967
SGTC_1420 4'-methoxyflavone 42 µM 1.01754630663389 0.233276115993458 no 798 0.154446807609597 797 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_233 rapamycin 362 pM 1.01677469320647 0.233467150291575 no 799 0.154630311782763 813 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1611 st001856 99.4 µM 1.01583646813491 0.233699550782203 no 800 0.154853633368225 763 647478
SGTC_2171 5739187 198.077 µM 1.01318012747957 0.234358227452771 no 801 0.155487065393286 727 2262761
SGTC_3354 9151612 71.43 µM 1.01010717267568 0.235121489436718 no 802 0.156221973078644 816 27261949
SGTC_1231 0242-0792 125 µM 1.00878561139739 0.23545016117316 no 803 0.156538731549603 792 3707635
SGTC_534 k292-0788 63.4 µM 1.00687975163376 0.235924593843889 no 804 0.156996281755084 885 4146317
SGTC_580 1123-0028 41 µM 1.00678997283458 0.235946955797635 no 805 0.157017857119015 883 1677248 YPR107C YTH1
SGTC_1723 st034307 2.5525 µM 1.00570071623432 0.23621835906062 no 806 0.157279779275025 791 867466
SGTC_1710 st031758 61.5 µM 1.0032131881695 0.236838805060251 no 807 0.157879005582754 774 5394341
SGTC_3053 9095903 49.47 µM 1.00302932477055 0.236884700304657 no 808 0.157923356279735 824 17174018
SGTC_1552 6-methylflavone 10.6 µM 1.00243771504242 0.237032408725848 no 809 0.158066117205785 762 689013
SGTC_1122 capsaicin 818.572 nM 1.00050011561703 0.23751652734434 no 810 0.158534270853591 821 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2056 5235370 200 µM 0.999029303688144 0.237884378881075 no 811 0.158890248019926 761 5511916
SGTC_2707 st078556 66.6 µM 0.998139655937021 0.238107032210731 no 812 0.159105821447814 804 17250899
SGTC_1930 st074634 34.3 µM 0.997509114115361 0.238264907884435 no 813 0.159258726048072 785 684253 YOR116C RPO31
SGTC_1838 st055369 84.5 µM 0.994170532040857 0.239101780127089 no 814 0.160069925902648 782 676036
SGTC_2661 dactinomycin 12.96 µM 0.992761482718815 0.239455463783334 no 815 0.160413102312055 840 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_963 1269-2853 151 µM 0.990292707228014 0.24007583612158 no 816 0.16101553505337 772 3668223
SGTC_88 0180-0332 8.668 µM 0.989323396351718 0.240319651133696 no 817 0.161252470294238 815 3101745
SGTC_1369 1866-0067 208 µM 0.988893484455188 0.240427831926268 no 818 0.161357629348773 872 3531355
SGTC_303 1348-1668 34.2 µM 0.98769853227037 0.240728662747077 no 819 0.161650156771795 811 5380509
SGTC_1315 1237-0019 3.69 µM 0.986809219932185 0.240952681214365 no 820 0.161868086980587 850 825140
SGTC_2480 5767542 37.17 µM 0.986697831611625 0.240980748006725 no 821 0.161895396700677 833 2867358
SGTC_551 k048-0028 34.9 µM 0.986418522973461 0.24105113391779 no 822 0.161963889618364 865 6836383
SGTC_631 k072-0230 41.5 µM 0.98252199890041 0.242034224650415 no 823 0.162921375304129 851 5773147
SGTC_2565 isoliquiritigenin 100 µM 0.982160801027525 0.24212546465463 no 824 0.163010317803466 647 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1445 4239-0156 97.7 µM 0.981570314943558 0.242274663917724 no 825 0.163155788918984 906 4008346
SGTC_2061 5245884 80.95 µM 0.981043703587166 0.242407765852447 no 826 0.163285595117239 827 573863
SGTC_1714 st033236 13.627 µM 0.980339485946551 0.242585819978448 no 827 0.163459284912268 831 2916566
SGTC_3215 9129942 49.47 µM 0.979994459626958 0.242673082147499 no 828 0.163544426748053 777 17682944
SGTC_2147 5545932 89.7195 µM 0.979805677685216 0.242720835035378 no 829 0.163591024485906 805 797404
SGTC_2109 5483026 200 µM 0.978486015854146 0.243054788977011 no 830 0.163917002182397 840 759335
SGTC_2909 7941780 10.49 µM 0.978252391870364 0.243113935798774 no 831 0.163974754947749 854 1243215
SGTC_3138 9097216 49.47 µM 0.977114035077489 0.243402246070763 no 832 0.164256350075822 889 25237486
SGTC_1497 4476-2978 41.3 µM 0.974990864999622 0.243940472080242 no 833 0.164782395641543 876 1528379
SGTC_1302 1159-0335 255 µM 0.973436271154245 0.244334970228202 no 834 0.165168259659136 806 649284
SGTC_1520 flindersine 88 µM 0.972507582237499 0.244570800921805 no 835 0.165399047327759 849 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2508 celastrol 40.54 µM 0.971482815657183 0.244831171736115 no 836 0.165653953180005 781 122724 Celastrol is a natural product and antioxidant.
SGTC_2698 st077697 67.5 µM 0.968888086343939 0.245491102399999 no 837 0.166300515134941 775 3154499
SGTC_566 0958-0068 16.5 µM 0.967607535816403 0.245817143182607 no 838 0.166620206138298 767 6815365
SGTC_3066 9117245 49.47 µM 0.966800305158881 0.246022791447524 no 839 0.166821935943003 877 17176980
SGTC_2441 5730946 39.09 µM 0.966443463950043 0.246113728921055 no 840 0.16691116202735 852 1774275
SGTC_501 nsc-95397 161 µM 0.965920027581715 0.24624715414518 no 841 0.167042099952301 820 262093
SGTC_1155 4088-0394 48.2 µM 0.965156788631863 0.246441775122972 no 842 0.167233143310802 819 2326248
SGTC_1234 0326-0494 15.5 µM 0.959877896378192 0.247790112028367 no 843 0.16855833595317 845 1547813
SGTC_2460 5552655 174.22 µM 0.958685518037833 0.248095214184202 no 844 0.168858598113876 819 5401989
SGTC_1020 4335-0961 93.3 µM 0.95792930360418 0.248288815840907 no 845 0.169049204385704 792 669075
SGTC_736 0958-0254 92.6 µM 0.957096776120037 0.248502047840371 no 846 0.169259205342932 879 6812352
SGTC_1885 st057546 99.9 µM 0.956366098984225 0.248689273680271 no 847 0.1694436529832 878 702008
SGTC_2197 6588183 93.1375 µM 0.95396281548101 0.249305611131637 no 848 0.170051232514984 822 884136
SGTC_579 4491-1009 110 µM 0.952250450084707 0.249745253166661 no 849 0.170484990306924 1062 1271041
SGTC_2400 5203494 178.7 µM 0.951656292987056 0.249897896452133 no 850 0.170635661150433 782 6777674
SGTC_2555 cholic acid 100 µM 0.949580335087181 0.250431613686936 no 851 0.171162767233614 847 6708657 Influences liver metabolism.
SGTC_2809 7964133 12.99 µM 0.9494970448735 0.250453039736168 no 852 0.171183937140026 843 1253665
SGTC_1035 k081-0041 55.2 µM 0.948574873739361 0.250690329202512 no 853 0.171418437624869 898 731709
SGTC_581 0958-0271 211 µM 0.947269106234774 0.251026527736052 no 854 0.17175083450699 902 4591145
SGTC_657 3534-0529 86.7 µM 0.947096450887571 0.251070999499266 no 855 0.171794816541914 879 1049549
SGTC_1470 k295-0292 231 µM 0.946691182817936 0.251175402940382 no 856 0.171898082343732 882 5045612
SGTC_3240 9133527 49.47 µM 0.94467610062153 0.251694860602798 no 857 0.172412131008555 831 17617455
SGTC_961 1252-1571 372 µM 0.943074702515524 0.25210808101679 no 858 0.172821347121999 871 6813498
SGTC_2335 9018011 154.17 µM 0.942593475655667 0.25223232537856 no 859 0.172944439142152 901 6458208
SGTC_979 1426-2828 121 µM 0.941598619443433 0.252489282196168 no 860 0.173199088414827 913 747872
SGTC_3193 9111931 49.47 µM 0.940701483741653 0.252721117458898 no 861 0.173428929213095 863 17087244
SGTC_1729 st035615 45.989 µM 0.940318169786935 0.252820206531999 no 862 0.173527191124342 830 17385451
SGTC_2173 5763948 167 µM 0.939143463930701 0.253124002740793 no 863 0.173828545685666 874 2867177
SGTC_858 0438-0351 2.77 µM 0.938861766500332 0.253196882372007 no 864 0.173900860720895 905 2799119
SGTC_1326 1431-2094 10.8 µM 0.936532046074573 0.253800041072638 no 865 0.174499660477383 846 616278
SGTC_451 chloral hydrate 100 µM 0.935929677044287 0.253956115525857 no 866 0.174654698069372 924 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2638 epoxomicin 18 µM 0.934624896284762 0.254294358224698 no 867 0.174990822009614 916 9915668 A protesome inhibitor.
SGTC_2386 9075165 157.42 µM 0.93453043019143 0.254318856152698 no 868 0.175015173297332 871 16452277
SGTC_2470 5664817 21.68 µM 0.932631798330831 0.254811491268187 no 869 0.175505054751449 872 2859561
SGTC_2260 7964312 200 µM 0.931834706860011 0.25501846016027 no 870 0.175710977581215 822 231951
SGTC_671 0560-0003 407 µM 0.93090944708511 0.255258818863651 no 871 0.175950203656136 850 3238678
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.930755720094783 0.255298764654321 no 872 0.175989969766708 824 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1358 1509-0022 2.48 µM 0.927248675936278 0.256210953136303 no 873 0.176898717646957 904 3258434
SGTC_2286 7945697 125 µM 0.927244512604054 0.256212037035461 no 874 0.176899798212022 862 1245733
SGTC_562 3772-2733 112 µM 0.925007631123205 0.256794741559137 no 875 0.177480968998003 948 2876874 YIL048W NEO1
SGTC_2846 9008642 19.48 µM 0.92192216815897 0.25759963088686 no 876 0.178284587528871 811 2992898
SGTC_773 4358-1457 44.6 µM 0.921553493014772 0.257695892880036 no 877 0.178380763258976 942 1186886
SGTC_1673 st016611 27.3 µM 0.921434269608241 0.25772702640235 no 878 0.17841187188295 917 5226799
SGTC_3331 9141060 1.957 µM 0.92028882241667 0.25802624335496 no 879 0.178710924299761 838 4906567 YPR165W RHO1
SGTC_1915 st067105 30.6 µM 0.919573678784992 0.258213146514409 no 880 0.178897793352081 873 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1444 4112-3581 28 µM 0.919279497471015 0.258290051321058 no 881 0.178974699447086 918 2877249
SGTC_790 1575-0012 79.1 µM 0.911873199428606 0.260230108084518 no 882 0.180917735639512 930 378741 YLR208W SEC13
SGTC_749 1000-0129 128 µM 0.911041038151506 0.260448558483105 no 883 0.181136875615832 956 708470
SGTC_2833 9001315 45.46 µM 0.910662636655836 0.260547923769073 no 884 0.181236578212428 873 2989378
SGTC_2083 5306046 65.942 µM 0.910439986385515 0.26060639911562 no 885 0.181295258970202 881 539837
SGTC_3304 9125678 46.087 µM 0.909891382989559 0.260750509389945 no 886 0.181439897314071 861 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1699 st031318 29.054 µM 0.909641397474522 0.260816190610096 no 887 0.18150582951796 945 5340658
SGTC_511 blebbistatin 171 µM 0.909050574758651 0.260971457254169 no 888 0.181661715117556 898 3476986 A myosin inhibitor.
SGTC_675 1309-0189 238 µM 0.907556910065972 0.261364200238305 no 889 0.182056184493926 855 4246530
SGTC_2887 9044784 58.44 µM 0.906174040713612 0.261728081227559 no 890 0.18242187041205 995 6465546
SGTC_2065 5221596 34.26 µM 0.903971512494228 0.262308179157443 no 891 0.183005253597242 865 788581
SGTC_2960 9079389 5.97 µM 0.902889397476622 0.262593425728325 no 892 0.183292299148691 908 16457355
SGTC_1415 3966-0071 78.1 µM 0.902882123693809 0.262595343641511 no 893 0.183294229566782 899 2893185
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.901978572893011 0.262833642953416 no 894 0.183534125094847 911 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1808 st050063 61.5 µM 0.901043612989333 0.263080342361129 no 895 0.183782565743658 898 4011993
SGTC_1324 1418-0026 34.4 µM 0.900757951538064 0.263155740855554 no 896 0.18385851441456 924 1372513
SGTC_1286 0929-0070 131 µM 0.898020929240119 0.263878719422028 no 897 0.184587195800588 933 1420408
SGTC_2144 5628481 200 µM 0.897496510950956 0.26401735889275 no 898 0.184727017178014 889 2818399
SGTC_2732 terfenadine 20 µM 0.897248776955905 0.264082864766803 no 899 0.184793091368248 898 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1349 flufenamic acid 69 µM 0.896312674971174 0.264330463785491 no 900 0.185042895728623 880 3371 A non-steroidal anti-inflammatory.
SGTC_1311 1190-0148 100 µM 0.89529232409906 0.264600481195094 no 901 0.185315421242475 1025 1961333
SGTC_3212 9128307 49.47 µM 0.894910165419168 0.264701648685417 no 902 0.185417556119253 785 27243542
SGTC_968 1309-0633 340 µM 0.894491369620713 0.264812537573539 no 903 0.185529522670851 920 3761976
SGTC_867 0518-0118 155 µM 0.894154900707327 0.264901645027607 no 904 0.185619509227932 948 6848158
SGTC_2321 7390090 138.78 µM 0.894131142937113 0.264907937401502 no 905 0.185625864122022 818 649046
SGTC_1147 3809-1045 12.3 µM 0.886745836833537 0.266867650643535 no 906 0.18760787714884 893 325925
SGTC_449 xestospongin c 11.1929 µM 0.886290848916601 0.266988622148088 no 907 0.187730409482234 932 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2803 7707263 71.43 µM 0.885968738780266 0.267074281048322 no 908 0.187817186514851 877 2199229
SGTC_1790 st045711 43.5 µM 0.885121095306116 0.267299761560765 no 909 0.188045661487682 920 585119
SGTC_2852 9023854 51.95 µM 0.884440344650787 0.267480916656918 no 910 0.188229276106019 916 19798528
SGTC_2110 5483698 200 µM 0.884351798448336 0.267504484306508 no 911 0.188253167247441 912 2848765 YHR062C RPP1
SGTC_1204 4049-0315 18.3 µM 0.882447273611602 0.268011650111874 no 912 0.188767490462237 898 588402
SGTC_2505 galangin 7.89 µM 0.882052178867715 0.268116922541776 no 913 0.188874295465206 858 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2417 cerulenin 830 nM 0.879980002494779 0.268669391575555 no 914 0.189435071428062 924 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1896 st058441 89 µM 0.878385512673157 0.26909489225521 no 915 0.189867271834787 852 688759
SGTC_390 dec-rvkr-cmk 16.7 µM 0.877465585773698 0.269340534871471 no 916 0.190116901638058 970 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1739 st037196 92.5 µM 0.877330359006744 0.269376653148449 no 917 0.190153613539413 981 612214
SGTC_157 1348-1695 65.819 µM 0.877304032122289 0.269383685187399 no 918 0.190160761373426 926 5380510
SGTC_591 4299-0174 154 µM 0.876661052853768 0.269555456646259 no 919 0.19033538356849 938 5509088
SGTC_3051 9093778 49.47 µM 0.875591210052468 0.269841385980701 no 920 0.190626152807239 909 17217378
SGTC_92 0063-0024 660.874 µM 0.875481013743581 0.269870845994001 no 921 0.190656118199562 1033 3594437
SGTC_3312 9133330 71.43 µM 0.875280430877153 0.269924474190373 no 922 0.190710669591144 996 17617324
SGTC_679 0422-0091 41.4 µM 0.873710454135079 0.270344410178367 no 923 0.191137978156359 991 627384 YHR062C RPP1
SGTC_1965 Pectolinarigenin 58.4 µM 0.873539732277121 0.270390094389322 no 924 0.191184479757044 959 5320438 An anti-inflammatory.
SGTC_1703 st026983 48.3 µM 0.871084331964128 0.27104757225079 no 925 0.191854054201639 975 1104023
SGTC_1901 st060216 58.6 µM 0.871023009954624 0.271064002529092 no 926 0.191870794736944 995 688792
SGTC_3334 9142812 21.919 µM 0.870915455295089 0.271092821326278 no 927 0.191900158663812 906 45283678
SGTC_1671 st016596 74.5 µM 0.87056548774203 0.271186604164331 no 928 0.191995723738505 988 2829167
SGTC_784 4579-0127 173 µM 0.870236680476866 0.271274731292859 no 929 0.192085537139975 1011 1948547
SGTC_2825 7998094 58.44 µM 0.869581846993961 0.271450282683775 no 930 0.192264480866172 905 2987815
SGTC_328 k915-0120 63.5 µM 0.869559644542641 0.271456235831853 no 931 0.192270549827826 950 6624543
SGTC_3191 9110352 49.47 µM 0.869504555825926 0.271471007062272 no 932 0.19228560864001 917 17122424
SGTC_2102 5377816 72.7585 µM 0.867729706935303 0.27194712087293 no 933 0.192771159548625 993 1379702
SGTC_2594 a-mangostin 100 µM 0.867594489047269 0.271983410898344 no 934 0.19280818220913 947 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2456 5770359 74.46 µM 0.866721897894827 0.272217656421721 no 935 0.193047202133497 978 3118787
SGTC_1092 toremifene 6.32 µM 0.866024062190605 0.272405061285958 no 936 0.193238483235769 1033 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1067 clotrimazole 1.36 µM 0.865738860868857 0.272481670987071 no 937 0.193316691978132 967 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1205 4161-2785 76 µM 0.86530370816169 0.27259858067407 no 938 0.193436058041993 836 3498106
SGTC_587 k089-0003 57 µM 0.865282595785028 0.272604253434169 no 939 0.193441850488761 878 9659696
SGTC_2687 chenodiol 100 µM 0.864616362923593 0.272783296022776 no 940 0.193624694229519 899 5702181 A cholesterol synthesis inhibitor.
SGTC_2238 6671620 73.2395 µM 0.864360993288302 0.272851939203069 no 941 0.193694806875334 993 729941
SGTC_2973 9094665 17.96 µM 0.863804632622405 0.273001518222458 no 942 0.193847611275517 992 25237061 YIL048W NEO1
SGTC_457 grayanotoxin iii 135 µM 0.863605118127535 0.27305516811732 no 943 0.193902425805264 973 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_236 1509-0011 5.31 µM 0.863307317567577 0.273135257076096 no 944 0.193984260978868 1111 3107280
SGTC_2275 7947463 200 µM 0.861154335930989 0.273714615006662 no 945 0.194576523145593 945 1225414
SGTC_145 3737-0113 38.366 µM 0.859758623713822 0.274090519542739 no 946 0.194961055865572 1069 6849351
SGTC_1499 4480-0877 67.3 µM 0.85937592300032 0.274193636142297 no 947 0.195066574416254 907 2861909
SGTC_1355 1499-0035 1.68 µM 0.858302979820486 0.274482836896259 no 948 0.195362592231543 927 1548538
SGTC_2149 5554786 194.827 µM 0.857921341863679 0.274585739745181 no 949 0.195467949341518 990 745063 YPR165W RHO1
SGTC_1422 4031-0024 15.5 µM 0.857197071293589 0.274781080560713 no 950 0.195667990392977 949 782427
SGTC_1972 st070201 17.4 µM 0.856803425748216 0.274887278233845 no 951 0.195776766056164 967 2829099
SGTC_3330 9141424 71.43 µM 0.855776817423334 0.275164331697055 no 952 0.196060620285155 1002 27261020
SGTC_2276 7947513 42.08 µM 0.855420031123653 0.275260650730996 no 953 0.196159329088535 922 2105100
SGTC_2673 kobusone 100 µM 0.853216307815211 0.275855941649271 no 954 0.196769680738577 1001 6710676 An epoxy ketone and protein crosslinker.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.853167939281357 0.275869014512935 no 955 0.19678308995874 1041 66535 A nucleotide analog.
SGTC_61 0978-8327 98.565 µM 0.852764447535726 0.275978080588241 no 956 0.196894971632885 1045 6150059 YHR072W ERG7
SGTC_1400 3771-8998 51.5 µM 0.852673769733308 0.276002594219385 no 957 0.196920120406146 927 670767
SGTC_1679 SEC14.276 6.7 µM 0.851372492056067 0.276354496400893 no 958 0.197281233659056 1027 1005053 YMR079W SEC14
SGTC_3341 9147222 25.867 µM 0.847604251080024 0.277374774789733 no 959 0.198329203034277 918 1939759
SGTC_2079 5212404 121 µM 0.847590022147321 0.277378630863371 no 960 0.198333166538028 997 758462
SGTC_639 0833-0042 114 µM 0.844811873966735 0.278132017161379 no 961 0.199107941965124 992 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_716 1683-5115 658 µM 0.843782874387557 0.278411317335326 no 962 0.199395373517435 1054 723597
SGTC_1306 1185-0270 9.02 µM 0.842421414393792 0.278781066776857 no 963 0.199776055280772 1007 1548076
SGTC_3179 9107801 49.47 µM 0.840387227907404 0.279333962261788 no 964 0.20034565396926 1007 4818259
SGTC_2689 tacrolimus 100 µM 0.83870823666838 0.279790716022537 no 965 0.200816527560315 957 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1848 st056003 16.4 µM 0.836926542805694 0.280275804969274 no 966 0.201316929791378 1079 146492
SGTC_3265 9137266 49.47 µM 0.836211563056929 0.280470581823665 no 967 0.201517947255232 976 17224265
SGTC_2418 pentamidine 31.67 µM 0.836114102770808 0.28049713731073 no 968 0.201545357649609 987 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2742 clothiapine 36.27 µM 0.833415096106075 0.28123303213437 no 969 0.202305331852308 945 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_399 oxolinic acid 75 µM 0.833096206920006 0.281320040069587 no 970 0.202395236320177 964 4628 A DNA gyrase inhibitor.
SGTC_1052 3253-3998 198 µM 0.830963241441765 0.2819023470357 no 971 0.202997197652509 1049 5450317
SGTC_2866 9034245 58.44 µM 0.830280089859674 0.282088972489959 no 972 0.203190221174233 1012 6462273
SGTC_50 0929-0078 56.389 µM 0.830115976186012 0.282133814429497 no 973 0.203236607578242 931 1377751
SGTC_1345 1488-0192 31.4 µM 0.828301164637468 0.282629916882932 no 974 0.203749981724155 1037 658348
SGTC_2629 bisabolol 100 µM 0.826964021478494 0.282995710503522 no 975 0.204128727133014 1006 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3284 9108171 64.8615 µM 0.825873272241598 0.283294267941205 no 976 0.204437991872918 934 8687505
SGTC_1531 st059297 52.4 µM 0.825409103652183 0.283421364930121 no 977 0.204569684102197 1011 7566702
SGTC_1441 4106-0040 13 µM 0.825289910341002 0.283454006428073 no 978 0.204603509339887 1025 2904180
SGTC_2780 5215298 71.43 µM 0.824028488345178 0.283799561573769 no 979 0.204961685516844 1034 2834131
SGTC_2168 5727979 200 µM 0.823374138313455 0.283978894259858 no 980 0.205147632567492 965 695210
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.822804613465892 0.284135023680729 no 981 0.205309556361065 925 61125 An anti-inflammatory.
SGTC_2591 skatole 100 µM 0.820751888765651 0.284698097563614 no 982 0.205893804024694 996 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2036 5160441 105 µM 0.820741523612958 0.284700942134113 no 983 0.205896756660799 1056 134534 YIL048W NEO1
SGTC_2421 5690543 90.72 µM 0.819690074209071 0.284989568114057 no 984 0.206196404929539 994 3397993
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.819299586610015 0.285096793640227 no 985 0.206307754194038 1058 676296 Flavone; oxidizing agent.
SGTC_1251 0490-5699 265 µM 0.81800390718876 0.285452717058616 no 986 0.206677478122758 1085 3883818
SGTC_2918 7977171 22.06 µM 0.815660729282242 0.286096925282958 no 987 0.207347102711013 1005 2236483
SGTC_376 3970-0862 59.1 µM 0.813765104721258 0.286618592896335 no 988 0.207889764622226 1040 3135186
SGTC_3187 9109394 49.47 µM 0.813591368350913 0.286666426946979 no 989 0.207939542186572 1025 17098090
SGTC_369 0957-0393 4.5 µM 0.810714306513778 0.28745910525979 no 990 0.208764877785875 1008 6997992
SGTC_1031 k035-0009 16 µM 0.810003795058237 0.287655022452518 no 991 0.208968997291578 1094 5180959
SGTC_728 3030-5151 22.5 µM 0.80804748504253 0.288194783311882 no 992 0.209531623512327 985 3125388
SGTC_818 4072-2707 53.5 µM 0.803675534538986 0.2894027616947 no 993 0.210792193575973 1036 882871
SGTC_2750 bromebric acid 70.15 µM 0.803306902951127 0.289504723958677 no 994 0.210898684539699 1061 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3090 9117696 49.47 µM 0.803104694210548 0.289560661384128 no 995 0.210957112364112 1022 7923821
SGTC_727 3032-0951 202 µM 0.79947182291756 0.290566493652605 no 996 0.212008439346199 998 3652836
SGTC_1178 0988-0033 191 µM 0.798388227652853 0.2908668246634 no 997 0.212322616369865 1051 5392207
SGTC_444 curcumin 90.4 µM 0.797668546918066 0.291066372689263 no 998 0.212531430493419 996 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_535 2293-4129 48.2 µM 0.797315617261244 0.291164253911825 no 999 0.212633876246374 1094 396118 YIL048W NEO1
SGTC_2104 5389443 200 µM 0.796304597103481 0.291444734460702 no 1000 0.212927507116606 1070 2244536
SGTC_2626 ethyl orsellinate 100 µM 0.795499767292121 0.291668103066988 no 1001 0.213161423135119 1037 75653 A natural product.
SGTC_866 0495-0101 262 µM 0.795463409643924 0.291678195477873 no 1002 0.213171993671817 974 635694
SGTC_2089 5281248 129.67 µM 0.794791206660958 0.291864819613127 no 1003 0.213367483450417 1020 2737878
SGTC_1613 st002381 52.1 µM 0.793966720602458 0.292093798113005 no 1004 0.213607402775234 1085 551167
SGTC_343 4130-2827 29.8 µM 0.793936795321636 0.292102110615212 no 1005 0.213616113764873 1038 1118244
SGTC_64 000l-0018 272.079 µM 0.789270482223788 0.293399641814823 no 1006 0.214976967488718 1061 6811119
SGTC_1635 st007035 42.4 µM 0.788532494475342 0.2936050935599 no 1007 0.215192649661658 1102 3716403
SGTC_1440 4100-1550 40 µM 0.781347725581788 0.295608765459252 no 1008 0.217299003695586 1095 742806
SGTC_2678 equilin 100 µM 0.780706368656136 0.295787930802291 no 1009 0.217487607013841 1100 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_190 3970-0790 3.722 µM 0.779631436853249 0.296088328652951 no 1010 0.21780392316409 1047 2832352
SGTC_677 0929-0063 136 µM 0.778309075033571 0.29645806463203 no 1011 0.218193413394428 1021 1539583
SGTC_1065 prochlorperazine maleate 2.48 µM 0.777300475555975 0.296740213969639 no 1012 0.218490757272457 1130 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3219 9131112 49.47 µM 0.775621943128584 0.29721004517644 no 1013 0.218986120135602 1028 17612988 YMR079W SEC14
SGTC_1796 st049173 110.4 µM 0.775079534195482 0.297361941318201 no 1014 0.219146332030793 1040 94134
SGTC_262 fenpropimorph 62.5 µM 0.773364466239734 0.297842461952947 no 1015 0.21965335664343 997 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_148 3253-0744 288.01 µM 0.77202578282255 0.298217774611453 no 1016 0.220049578557925 1097 6893655
SGTC_1173 0443-0020 122 µM 0.771920615954216 0.29824726826823 no 1017 0.220080723082921 1070 5331295
SGTC_3058 9093861 49.47 µM 0.771029933922631 0.29849710997181 no 1018 0.220344594492714 1060 17217477
SGTC_2004 4023728 41.89 µM 0.76997818724385 0.298792253823991 no 1019 0.220656415946046 1090 360084 YDR527W RBA50
SGTC_839 0122-0028 230 µM 0.769598203533842 0.29889891843225 no 1020 0.220769135500496 1089 759448
SGTC_1410 3909-8106 77.9 µM 0.768544652568565 0.299194749438159 no 1021 0.221081836551761 1105 1039210
SGTC_1570 verbenone 133 µM 0.763340336232701 0.300658036551882 no 1022 0.222630226106463 1095 29025 A natural terpanoid with antifungal properties.
SGTC_621 3584-0052 32.1 µM 0.763053283516993 0.30073884050645 no 1023 0.222715809619286 1123 2273927
SGTC_3132 9126706 49.47 µM 0.762799804971438 0.300810201640291 no 1024 0.222791398727098 1061 850858
SGTC_2588 indole-3-carbinol 100 µM 0.762060069090646 0.301018501157141 no 1025 0.223012076800359 1093 3712 Induces cell cycle arrest.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.760202431075532 0.301541873067421 no 1026 0.223566796029198 1093 6708739 YPR165W RHO1
SGTC_187 1488-2104 32.728 µM 0.760073639218648 0.301578174124488 no 1027 0.223605284323039 1141 2852859
SGTC_1521 st012942 49.4 µM 0.759201848183503 0.301823947358908 no 1028 0.223865910330778 1126 24207259
SGTC_2402 5553605 200 µM 0.758731099258464 0.301956697182647 no 1029 0.224006714674394 1116 6758546
SGTC_1094 duloxetine 25.4 µM 0.758168994316819 0.302115243484636 no 1030 0.224174910139497 1105 60834 A selective serotonin reuptake inhibitor.
SGTC_178 4092-0806 87.505 µM 0.757763729766084 0.302229574851351 no 1031 0.2242962196268 1069 2169044
SGTC_2994 9053520 71.4286 µM 0.75757474215088 0.302282897803845 no 1032 0.224352802798176 1088 4647384
SGTC_1014 4130-3005 69.3 µM 0.757568355803146 0.30228469978886 no 1033 0.224354715021648 1129 743608
SGTC_2952 9073731 13.78 µM 0.756577386386646 0.302564372133801 no 1034 0.224651546764492 1158 16457353
SGTC_1460 k062-0059 9.15 µM 0.755509736732822 0.302865814962435 no 1035 0.22497159619019 1095 1373085
SGTC_1299 1079-1439 3.74 µM 0.755487119768392 0.302872202145909 no 1036 0.224978378873502 1100 323161
SGTC_3355 9151058 44.0485 µM 0.755159578449416 0.302964708785792 no 1037 0.225076619416923 1130 17015728
SGTC_3205 9113483 49.47 µM 0.75507645266754 0.302988187795065 no 1038 0.225101555472293 1093 17018033
SGTC_1267 0828-0272 9.49 µM 0.753233106240631 0.303509053007955 no 1039 0.225654924223633 1124 745334
SGTC_2325 6158266 200 µM 0.751042236231185 0.304128635789371 no 1040 0.226313618726512 1116 3623240
SGTC_2863 9028737 58.44 µM 0.750602469766831 0.3042530705856 no 1041 0.226445967172057 1106 6460917
SGTC_1825 st052143 62.6 µM 0.749939564619573 0.304440686771445 no 1042 0.226645552144593 1091 674173
SGTC_317 4495-0002 170 µM 0.749633131591213 0.304527431202768 no 1043 0.226737845385401 1057 15991618
SGTC_2641 levomentholum 100 µM 0.748395698125295 0.304877833131933 no 1044 0.22711075828157 1085 16666
SGTC_162 k030-0015 37.8 µM 0.747991302198821 0.304992384066866 no 1045 0.227232701939893 1164 1809920 YMR134W ERG29
SGTC_801 0866-0028 10.1 µM 0.746922373867706 0.305295265321021 no 1046 0.227555209780945 1147 6849771
SGTC_761 k216-0224 480 µM 0.746744003231525 0.305345819698244 no 1047 0.22760905131467 1155 1340404
SGTC_669 0108-0021 26.2 µM 0.746225423749114 0.305492818242572 no 1048 0.227765626303488 1182 17201
SGTC_658 3253-0951 102 µM 0.746152272577566 0.305513556480953 no 1049 0.22778771775471 1145 1184878
SGTC_1190 1486-1332 13 µM 0.742897262984375 0.306436977289387 no 1050 0.228771941453102 1122 4150046
SGTC_886 0866-0150 153 µM 0.74144148225663 0.306850369531717 no 1051 0.229212900213237 1156 271463
SGTC_2232 chlorophetanol 41.5365 µM 0.741307223816619 0.306888506749558 no 1052 0.229253591341914 1200 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_125 0133-0007 11.75 µM 0.740751240988488 0.307046460504552 no 1053 0.229422142061083 1204 26541
SGTC_1252 0493-0875 34.8 µM 0.740368643353614 0.307155176633503 no 1054 0.229538169978012 1135 3960963
SGTC_2025 5147754 141 µM 0.73863306057987 0.307648559838955 no 1055 0.230064921627183 1137 315777 YLR208W SEC13
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.738057281327943 0.307812316565128 no 1056 0.230239820687414 1128 6708514
SGTC_3047 9092122 49.47 µM 0.737384969898909 0.308003576353746 no 1057 0.230444136500036 1120 17173831
SGTC_78 0336-0123 156.75 µM 0.734505081335998 0.308823439523248 no 1058 0.231320482199317 1007 6765896
SGTC_1724 st037281 8.293 µM 0.733725567225725 0.309045520227538 no 1059 0.231558006417716 1151 574124 YDL195W SEC31
SGTC_99 0109-0120 622.8 µM 0.733422453879713 0.309131894960535 no 1060 0.231650404189675 1140 759414
SGTC_1917 st066507 28.5 µM 0.733085112798571 0.309228035585098 no 1061 0.2317532597254 1109 3156428
SGTC_3317 9138495 8.753 µM 0.732979624301421 0.309258101993253 no 1062 0.231785428464807 1153 17020139
SGTC_2240 6690706 185.951 µM 0.732230832447014 0.309471559895901 no 1063 0.232013844182643 1051 805876
SGTC_3148 9097893 49.47 µM 0.72845428413329 0.310549118317197 no 1064 0.233167771878898 1109 17174100
SGTC_2734 clemastine 41.6 µM 0.728077662161398 0.310656668855533 no 1065 0.233283023501125 1091 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1864 st057645 30.4 µM 0.727342825975581 0.310866559884259 no 1066 0.233507984703733 1181 688666
SGTC_3206 9114350 49.47 µM 0.724850669105465 0.311578851913325 no 1067 0.234271823623138 1085 17087243
SGTC_1637 st007924 17.4 µM 0.724755304042164 0.311606122568929 no 1068 0.234301080190701 1151 683336
SGTC_1934 st074720 32.6 µM 0.723416094875879 0.311989192787828 no 1069 0.234712142959706 1187 17250992
SGTC_300 r073-0011 5.04 µM 0.722788342873966 0.312168826351377 no 1070 0.234904965104902 1195 2735780
SGTC_709 3807-1509 243 µM 0.721334337904364 0.312585066752142 no 1071 0.235351917553939 1174 1886677 YPL242C IQG1
SGTC_2585 alliin 100 µM 0.721155532181332 0.312636270286278 no 1072 0.235406913760335 1206 87310 A garlic compound which reacts with lipids.
SGTC_3180 9109287 49.47 µM 0.721082180720138 0.312657276555202 no 1073 0.23542947690232 1142 18891271
SGTC_3091 9116372 49.47 µM 0.719147352471005 0.313211588998345 no 1074 0.236025066952157 1172 17169793
SGTC_1372 2752-0194 270 µM 0.718487614205766 0.313400695224851 no 1075 0.236228341061267 1123 823334
SGTC_1619 st003326 88.7 µM 0.717722276504587 0.313620131764335 no 1076 0.236464272506039 1134 2849032
SGTC_1881 5652484 16 µM 0.715687135855384 0.314203965173591 no 1077 0.237092277912542 1131 2255129
SGTC_370 0180-0345 38.7 µM 0.71385607098161 0.314729651750094 no 1078 0.237658091770234 1103 3989527
SGTC_1975 st070967 30.8 µM 0.713077460147008 0.314953299663462 no 1079 0.237898913125023 1182 261391
SGTC_999 SEC7.066 22.7 µM 0.711773508104066 0.315327998386123 no 1080 0.2383025200158 1187 740511 YDR170C SEC7
SGTC_1082 camptothecin 424.86 nM 0.710868759501932 0.315588095212613 no 1081 0.238582783363783 1142 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1969 st069479 40.1 µM 0.709919287357267 0.315861147416665 no 1082 0.238877094592032 1145 3895485
SGTC_527 4476-4215 268 µM 0.708005064936511 0.316411951036938 no 1083 0.239471056078585 1129 4418754
SGTC_1149 3909-7961 23.3 µM 0.706360287952783 0.316885549257915 no 1084 0.239982055175709 1154 735261
SGTC_2525 harmine 47.85 µM 0.705880943324431 0.317023628610649 no 1085 0.240131089719029 1140 5280953 A monoamine oxidase inhibitor
SGTC_2243 6634756 200 µM 0.703890709170171 0.317597205107019 no 1086 0.240750418912307 1210 885676
SGTC_2903 5923464 63.88 µM 0.703317276040077 0.317762547308997 no 1087 0.240929023347418 1220 2876576
SGTC_1289 0976-0073 69.1 µM 0.70290185754094 0.317882350692979 no 1088 0.24105845673607 1210 3391136
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.702038685145551 0.318131343683772 no 1089 0.241327519222463 1201 3256 An antibiotic and ribosome inhibitor.
SGTC_1883 5-benzylidenerhodanine 20 µM 0.699249472180267 0.31893648903917 no 1090 0.242198069037208 1189 1273210
SGTC_3234 9132280 49.47 µM 0.698168776202459 0.319248677131053 no 1091 0.242535825380685 1196 17612295
SGTC_1742 st038235 28.8875 µM 0.697388410755899 0.319474186403458 no 1092 0.242779876156735 1160 564103 YBR002C RER2
SGTC_2397 5161689 200 µM 0.696584745629439 0.319706498600002 no 1093 0.243031352514675 1225 2259942
SGTC_3112 9123419 49.47 µM 0.696179389636268 0.319823700050782 no 1094 0.243158246648602 1248 17015854
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.694784461938239 0.320227155915989 no 1095 0.243595193573296 1214 551469
SGTC_2407 paclitaxel 400 µM 0.694618522442421 0.320275164867214 no 1096 0.24364720064083 1213 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_590 k048-0076 22.4 µM 0.694056041742668 0.3204379219124 no 1097 0.243823532212262 1187 6832814
SGTC_2249 haloperidol 116.36 µM 0.691961224339136 0.321044373104562 no 1098 0.244480840115749 1214 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2052 5265182 7.135 µM 0.691177816185827 0.321271293154807 no 1099 0.244726901511631 1194 1239884
SGTC_1281 0884-0031 11.8 µM 0.688716023468663 0.321984803952285 no 1100 0.245500995322352 1236 1548255
SGTC_1456 k015-0012 13 µM 0.687581934652394 0.322313722378575 no 1101 0.24585804386 1275 2989616
SGTC_42 0133-0086 60.653 µM 0.686803181547102 0.322539663824178 no 1102 0.246103382314738 1169 162923 Model of phenazepam hydroxylation.
SGTC_2258 7960471 200 µM 0.686415819705621 0.322652074432543 no 1103 0.246225465713478 1167 2974708
SGTC_1705 st027868 56.3335 µM 0.685849408405709 0.322816473542871 no 1104 0.246404037907951 1221 292948
SGTC_105 0111-0055 734.78 µM 0.685776268727762 0.322837704631329 no 1105 0.246427101674799 1165 5179370
SGTC_2003 4023581 200 µM 0.685207434542188 0.323002846322318 no 1106 0.246606516556394 1224 16641307
SGTC_988 1497-1057 103 µM 0.684780055732657 0.323126944210187 no 1107 0.246741361291878 1217 3533044
SGTC_3107 9121808 49.47 µM 0.684470238181174 0.323216918172723 no 1108 0.246839138279539 1166 662681
SGTC_166 k072-0058 166.424 µM 0.684428708778506 0.323228979492274 no 1109 0.246852246343368 1233 5846229
SGTC_3025 9087895 49.47 µM 0.683852840207905 0.323396247250081 no 1110 0.24703404805896 1227 17173641
SGTC_1898 st060199 18.6 µM 0.683509755428438 0.323495917207064 no 1111 0.247142393970427 1239 688866
SGTC_308 4092-1169 104 µM 0.683193955414938 0.323587671829956 no 1112 0.247242145833199 1188 2268590 YDL196W YDL196W
SGTC_3346 9158254 43.5805 µM 0.683047320551386 0.323630279739149 no 1113 0.247288470757525 1180 17639500
SGTC_1292 0kpi-0043 232 µM 0.682614514497701 0.323756054316427 no 1114 0.247425230016504 1208 3333905
SGTC_2329 6138490 200 µM 0.682522985680192 0.323782655410675 no 1115 0.247454156723487 1185 720019
SGTC_1661 st013063 9.66 µM 0.680671510375017 0.324320944296542 no 1116 0.248039683578382 1243 721395
SGTC_3039 9090270 49.47 µM 0.676294391304741 0.32559498576048 no 1117 0.249426876521874 1219 17173750
SGTC_2715 st079500 56.4 µM 0.676062122648627 0.325662648978595 no 1118 0.249500601941773 1193 28246688
SGTC_1290 0986-0249 10.2 µM 0.674169764423826 0.326214134175897 no 1119 0.25010169495415 1186 53329
SGTC_976 1348-1067 47.6 µM 0.671944095122172 0.326863241945983 no 1120 0.250809643558006 1276 5310671 YGL099W LSG1
SGTC_397 arbidol 50 µM 0.670094153362424 0.327403169361403 no 1121 0.25139888586858 1270 131410 A RNA synthesis inhibitor.
SGTC_2466 5983409 37.09 µM 0.669253935999532 0.327648516120606 no 1122 0.251666752821047 1222 2879657
SGTC_1040 k898-0338 155 µM 0.668963295950063 0.327733401485356 no 1123 0.25175944590407 1278 20969351
SGTC_3202 9113761 49.47 µM 0.667800159899906 0.328073200202493 no 1124 0.252130582246998 1278 4798415
SGTC_2935 9038016 29.96 µM 0.666226851127101 0.328533053285952 no 1125 0.252633056339081 1229 6463195
SGTC_1572 epiandrosterone 68.9 µM 0.66549895234103 0.328745894459672 no 1126 0.25286570670729 1197 441302 A steroid.
SGTC_15 0266-0086 27.098 µM 0.665318068275306 0.32879879446879 no 1127 0.252923538202577 1323 1712902 YIL048W NEO1
SGTC_2865 9030313 51.95 µM 0.664991049870505 0.328894440546172 no 1128 0.253028108821641 1193 42562754
SGTC_3115 9123671 49.47 µM 0.662856122988742 0.329519137369431 no 1129 0.253711352637667 1317 3286988
SGTC_2333 9017922 200 µM 0.661870921822338 0.32980757581845 no 1130 0.254026974410838 1276 3163164
SGTC_2359 9039622 200 µM 0.661378158006764 0.329951880824781 no 1131 0.254184914839561 1219 6463596
SGTC_1235 benzylparaben 21.5 µM 0.660702916495058 0.330149665198773 no 1132 0.254401426538392 1235 7180
SGTC_1716 st033144 30.6155 µM 0.660609780972388 0.330176949166488 no 1133 0.254431297407449 1268 674617
SGTC_404 fumagillin 50 µM 0.660369764509876 0.330247265935822 no 1134 0.254508285102941 1245 12015870 A methionine aminopeptidase binder.
SGTC_1121 fusaric acid 630.51 nM 0.658592489517545 0.33076813429656 no 1135 0.25507874352171 1255 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_183 3914-0051 30.55 µM 0.658503106688212 0.33079433850864 no 1136 0.255107450707388 1247 1596232
SGTC_1114 scopoletin 1.73284 µM 0.655386072052152 0.331708672116818 no 1137 0.256109608284254 1276 5280460 A coumarin with genotoxic properties.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.654692259301916 0.33191232802337 no 1138 0.256332955015555 1275 136420
SGTC_2305 7443522 69.23 µM 0.653332499682656 0.332311604351816 no 1139 0.256770972373239 1235 5415886
SGTC_2301 7769476 200 µM 0.651277218265583 0.332915473200208 no 1140 0.257433775903173 1278 977820
SGTC_2608 thymoquinone 42.66 µM 0.650757449499633 0.333068256890283 no 1141 0.257601535789267 1194 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1241 0364-0022 50.8 µM 0.650024552372961 0.333283735785958 no 1142 0.25783818113131 1282 4563895
SGTC_1162 k048-0130 20.1 µM 0.648231605195985 0.333811111616092 no 1143 0.258417581528257 1256 6797406
SGTC_1352 1496-0991 99 µM 0.647672417882886 0.333975657699909 no 1144 0.258598423769828 1265 3000039
SGTC_2882 9058044 58.44 µM 0.646743665435041 0.334249022303912 no 1145 0.258898928817971 1226 18076804
SGTC_1744 st037937 38.9 µM 0.646310144994772 0.334376652772659 no 1146 0.259039259533335 1308 1016152
SGTC_3285 9112818 20.8695 µM 0.639186091588963 0.336476741030276 no 1147 0.261350939494131 1312 17017947 YPR165W RHO1
SGTC_1380 2291-0730 164 µM 0.638891134787212 0.336563801508435 no 1148 0.261446877786882 1275 2999191
SGTC_1287 0971-0001 34.6 µM 0.636807078817335 0.337179188160291 no 1149 0.262125257294702 1297 4665869
SGTC_2112 5488546 200 µM 0.635501147068103 0.337565030109943 no 1150 0.26255080942073 1277 600757
SGTC_2126 5251174 33.877 µM 0.635466504890738 0.337575267585893 no 1151 0.262562102765105 1340 790722
SGTC_2783 7738165 71.43 µM 0.63546512934405 0.337575674090714 no 1152 0.262562551198242 1225 17201110
SGTC_68 0986-0284 82.829 µM 0.635387332375034 0.337598665144029 no 1153 0.262587913926146 1257 423278 YIL048W NEO1
SGTC_121 0557-0495 61.343 µM 0.632877145067916 0.338340816496669 no 1154 0.263406936884325 1391 3104427
SGTC_2819 7996655 46.38 µM 0.631332198654262 0.338797901444788 no 1155 0.263911668964405 1216 6456960
SGTC_3314 9135860 59.4275 µM 0.628456736159471 0.339649262321514 no 1156 0.264852389912154 1293 25252478
SGTC_3342 9147791 14.508 µM 0.627296725045075 0.339992948003946 no 1157 0.265232374883879 1258 1838168
SGTC_2136 5328288 199.296 µM 0.626368562036871 0.340268038024033 no 1158 0.265536612563337 1274 262395
SGTC_3098 9119039 49.47 µM 0.624143848863846 0.340927747009316 no 1159 0.266266559582674 1309 17161528
SGTC_185 k048-0037 25.491 µM 0.623907537860918 0.340997850511197 no 1160 0.266344154829951 1300 6827589
SGTC_2736 butenafine 14.65 µM 0.62383439818277 0.341019549079737 no 1161 0.266368173344837 1296 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_326 k292-0812 17.5 µM 0.623589004516736 0.341092354598986 no 1162 0.266448766767638 1289 3579357
SGTC_2968 9090663 33.37 µM 0.622395633093532 0.341446498684728 no 1163 0.266840875596123 1305 25236811
SGTC_2686 alizarin 95.37 µM 0.621235909530865 0.341790791265755 no 1164 0.267222207812182 1273 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_943 3253-1379 105 µM 0.620127210533415 0.342120059030458 no 1165 0.267587019453189 1342 668464
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.620105598412298 0.342126478715741 no 1166 0.26759413330334 1275 688662
SGTC_2827 7993847 71.43 µM 0.6161898638814 0.34329036376648 no 1167 0.26888460872547 1312 2985692
SGTC_2373 9071805 200 µM 0.614363189612779 0.343833821065912 no 1168 0.269487677371524 1354 10149009
SGTC_2553 4-methylesculetin 85.09 µM 0.614183708328444 0.343887236317051 no 1169 0.269546968901827 1314 5319502
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.614153883329788 0.343896112807959 no 1170 0.269556822204885 1197 6708630 An antioxidant.
SGTC_483 fpl-64176 144 µM 0.613985955488481 0.343946092956191 no 1171 0.269612303997404 1340 3423
SGTC_2007 4011539 71.82 µM 0.613308745196123 0.344147677852263 no 1172 0.269836106005404 1345 45595301
SGTC_3101 9120531 49.47 µM 0.613190803794624 0.344182789949018 no 1173 0.269875092360951 1371 24824904
SGTC_3356 9151811 4.48 µM 0.610141580032533 0.345091033741026 no 1174 0.270884012422853 1303 1859254 YPR165W RHO1
SGTC_2575 plumbagin 510 nM 0.609384224781685 0.345316758736793 no 1175 0.271134895871769 1287 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_469 w7 172 µM 0.608000567362185 0.345729291243717 no 1176 0.271593548799974 1355 45115570 A P450 inhibitor.
SGTC_430 0958-0115 16.4 µM 0.604235308784467 0.346852816202297 no 1177 0.272843604554454 1337 6833180
SGTC_1820 st053765 18.6 µM 0.60395295644389 0.346937122477669 no 1178 0.272937459675692 1301 3690829
SGTC_3311 9131146 2.8755 µM 0.602803765926226 0.347280332089827 no 1179 0.273319620598674 1327 4900406 YPR165W RHO1
SGTC_1049 3226-0134 66 µM 0.602351591768116 0.347415409781429 no 1180 0.273470062796531 1347 5702385
SGTC_544 k015-0020 52.4 µM 0.600342385700298 0.348015852772679 no 1181 0.274139038131455 1343 3008304
SGTC_1515 3460-0031 42.1 µM 0.598193986874271 0.348658314762976 no 1182 0.274855251609049 1300 2876596
SGTC_545 4218-0007 221 µM 0.59481403942156 0.349669940319726 no 1183 0.275983890972593 1318 2840508
SGTC_355 1311-2252 105 µM 0.594457243463245 0.349776792585279 no 1184 0.276103165735472 1313 5338538
SGTC_2644 guaiazulene 100 µM 0.593808939459554 0.349970975323247 no 1185 0.276319954646121 1357 3515 A coloring agent.
SGTC_712 r015-0009 80.6 µM 0.593058108150859 0.350195916510256 no 1186 0.276571132377647 1356 6813872 YLR060W FRS1
SGTC_1471 k673-0312 37 µM 0.592866531745237 0.350253319212657 no 1187 0.276635238894349 1351 24099884
SGTC_2293 7624732 200 µM 0.59227173572381 0.350431561799952 no 1188 0.276834319718493 1297 894453
SGTC_822 1487-0950 154 µM 0.590712759028831 0.350898896744236 no 1189 0.277356448769695 1364 1958375
SGTC_2201 6605497 169.863 µM 0.589466501949385 0.351272649967023 no 1190 0.277774188481889 1374 670741
SGTC_1872 amphotericin b 148 nM 0.587864247060383 0.351753378508782 no 1191 0.278311708045653 1348 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2388 9080168 200 µM 0.587232280911473 0.351943054145704 no 1192 0.278523857458816 1304 15943073
SGTC_474 dl-dihydrosphingosine 5 µM 0.586806913249825 0.352070742941536 no 1193 0.278666696632722 1391 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_31 0508-1974 57.237 µM 0.584600933890293 0.35273321113935 no 1194 0.279408039801465 1333 6810525
SGTC_2878 9043973 25.97 µM 0.584407640063678 0.35279127969821 no 1195 0.279473043897505 1424 6465167
SGTC_2693 st077581 40.7 µM 0.583517587887747 0.353058709851996 no 1196 0.279772460332455 1368 25238761
SGTC_2630 antimycin a 100 µM 0.581829201319418 0.353566211493785 no 1197 0.280340866305429 1331 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2115 tiliquinol 12.7705 µM 0.581769100057635 0.353584281764204 no 1198 0.280361110077149 1391 71208 A bioactive hydroxyquinoline.
SGTC_3251 9135047 49.47 µM 0.581626956336841 0.353627020540529 no 1199 0.280408990840916 1430 17682963
SGTC_26 0302-0163 425.158 µM 0.573594433791344 0.356045166750268 no 1200 0.28312113964302 1381 3100915
SGTC_1597 7-benzyloxygramine 47.5 µM 0.573493103367725 0.35607570896915 no 1201 0.283155433695337 1366 260807
SGTC_2614 arthonioic acid 13.39 µM 0.573134785517373 0.356183717721623 no 1202 0.283276718006251 1315 6710684
SGTC_1525 8-methoxypsoralen 92.5 µM 0.571505115574988 0.356675099177236 no 1203 0.283828646839918 1460 4114 Related to psoralen; DNA damaging agent.
SGTC_495 decylubiquinone 155 µM 0.571464148571031 0.356687454702544 no 1204 0.283842527979936 1332 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_515 4092-1064 102 µM 0.569672879638462 0.35722784290006 no 1205 0.284449793855273 1491 717353
SGTC_2560 caryophyllene 100 µM 0.569413704232875 0.357306054423332 no 1206 0.284537709410875 1403 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2769 toremifene 3.73 µM 0.569307387705998 0.357338139361915 no 1207 0.284573777066512 1406 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1798 st045719 60.953 µM 0.568584033976399 0.357556464830512 no 1208 0.284819231223409 1326 3980186
SGTC_2967 9089538 49.85 µM 0.567224592566173 0.357966902883905 no 1209 0.285280800856436 1451 728216
SGTC_2212 7123476 200 µM 0.564969647865505 0.358648070290855 no 1210 0.286047204573532 1381 1085715
SGTC_1954 st077032 68.9 µM 0.564741394636665 0.358717045499666 no 1211 0.286124837081053 1307 698907
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.563113424532957 0.359209130778338 no 1212 0.286678825350601 1436 364106
SGTC_860 0443-0016 25.1 µM 0.56047213934911 0.360008006807906 no 1213 0.287578719003308 1394 5337942
SGTC_3225 9130819 49.47 µM 0.560227945676948 0.360081895921205 no 1214 0.287661983898063 1433 4547121
SGTC_1384 3089-0840 101 µM 0.556615074389285 0.361175702689943 no 1215 0.288895226087555 1456 1069836
SGTC_3186 9110464 49.47 µM 0.554397821279596 0.361847545335187 no 1216 0.289653308413466 1438 17018021
SGTC_439 amiodarone 34.4 µM 0.554010708677639 0.361964886803169 no 1217 0.28978575850286 1451 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2211 7117706 200 µM 0.55080919319571 0.362935825827185 no 1218 0.290882240728768 1430 822771
SGTC_2914 7968218 45.32 µM 0.550202504499139 0.36311991879621 no 1219 0.291090242982537 1464 2977111
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.548947798949924 0.363500745609933 no 1220 0.291520637038912 1308 4000243
SGTC_896 0964-0007 44.5 µM 0.548632532270051 0.363596456223227 no 1221 0.291628827697109 1397 6756758
SGTC_361 000s-0510 1.45 µM 0.546046156919755 0.364381965016466 no 1222 0.292517104836634 1408 660
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.54551159569872 0.364544387933882 no 1223 0.292700853787833 1432 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_468 gf-109203x 121 µM 0.545487090467472 0.364551834270748 no 1224 0.292709278449483 1383 2396 A protein kinase C inhibitor.
SGTC_2183 6420625 130.508 µM 0.543702806160006 0.36509415698584 no 1225 0.293323000543596 1401 2897619
SGTC_161 4065-0411 162.148 µM 0.542701199511562 0.365398707804118 no 1226 0.293667774108361 1474 1906281 YLR208W SEC13
SGTC_2489 cantharidin 73.42 µM 0.542325178904033 0.365513063421011 no 1227 0.293797256529982 1387 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2861 9024595 19.48 µM 0.540962440859132 0.36592760025591 no 1228 0.294266735557045 1389 16482810
SGTC_2231 micatex 6.853 µM 0.540504896083094 0.366066817798556 no 1229 0.294424442695906 1448 20737 An antifungal of unknown mechanism.
SGTC_659 k018-0002 107 µM 0.539422259044751 0.366396302901392 no 1230 0.294797762765018 1444 6797879 YHR007C ERG11
SGTC_550 4123-0385 25.7 µM 0.539419955515484 0.366397004052691 no 1231 0.294798557311581 1394 5731123
SGTC_2496 diffractaic acid 79.83 µM 0.539001537334682 0.366524370129923 no 1232 0.294942896890746 1542 94870 An apoptosis inducer which activates caspases.
SGTC_2367 9070478 135.38 µM 0.538802125506688 0.366585076065203 no 1233 0.295011698425169 1445 572802
SGTC_3351 9150312 21.596 µM 0.538411400254936 0.366704032255333 no 1234 0.295146528795436 1426 4904905
SGTC_2374 9071832 200 µM 0.538280793355171 0.366743798344066 no 1235 0.295191604583532 1391 17381698
SGTC_620 0109-0052 432 µM 0.538268061952176 0.366747674770923 no 1236 0.29519599868649 1457 493037
SGTC_1050 3232-1156 69.3 µM 0.538201249818069 0.366768017791051 no 1237 0.295219058649405 1396 700529
SGTC_2937 9044753 11.33 µM 0.53688616114993 0.36716851330745 no 1238 0.29567312537889 1387 6465530 YGL099W LSG1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.536700351054034 0.36722511135633 no 1239 0.295737306758296 1517 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1487 3970-0795 2.82 µM 0.534374659700133 0.367933764306541 no 1240 0.296541173673051 1460 3765103
SGTC_1664 st014217 9.02 µM 0.531024909707064 0.368955244318401 no 1241 0.297700758827568 1482 3982782
SGTC_3146 9095609 49.47 µM 0.530924601129941 0.368985846952561 no 1242 0.297735514596722 1492 17173999
SGTC_2017 5132927 60.65 µM 0.527991681566487 0.369881002908355 no 1243 0.298752554763949 1396 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_798 1287-0182 476 µM 0.524843483010827 0.370842649180137 no 1244 0.299846000389722 1537 1649755
SGTC_3030 9087619 49.47 µM 0.524411939708573 0.370974531108923 no 1245 0.299996026928217 1408 25236973
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.524098175552666 0.371070428621222 no 1246 0.300105128727957 1475 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_630 4356-0227 183 µM 0.522770716884713 0.371476235848314 no 1247 0.300566909944257 1464 779312
SGTC_897 1000-0139 31.4 µM 0.521007465507778 0.37201548683059 no 1248 0.301180785369928 1521 6151020
SGTC_89 0302-0250 142.109 µM 0.520794710168851 0.372080570290495 no 1249 0.301254894249377 1516 4203518 YLR208W SEC13
SGTC_9 0092-0002 10.449 µM 0.519719353329769 0.372409585929248 no 1250 0.301629597945857 1451 759368
SGTC_1802 st050112 57.9 µM 0.518605946254908 0.372750341546054 no 1251 0.302017780811039 1443 4662563
SGTC_980 1473-0395 201 µM 0.51824591493758 0.372860549608362 no 1252 0.302143351613224 1406 768876
SGTC_2478 5763493 32.33 µM 0.5177879837668 0.373000740524459 no 1253 0.302303101529821 1493 1365576 YLR208W SEC13
SGTC_1997 st073024 93.8 µM 0.517719397409851 0.373021738980512 no 1254 0.302327031236904 1436 686268
SGTC_234 nsc-17383 10.7 µM 0.514233281171681 0.374089546833243 no 1255 0.303544450907357 1526 408974
SGTC_2997 9067075 71.4286 µM 0.510273028941139 0.375303756723008 no 1256 0.304930097736369 1512 27209819
SGTC_1379 2144-0755 36.5 µM 0.509740981910343 0.375466976359909 no 1257 0.305116468822792 1515 5392327
SGTC_419 nsc-638432 893 µM 0.509187104399588 0.375636916764158 no 1258 0.305310540626789 1471 368090
SGTC_699 0375-0592 111 µM 0.509152578500465 0.375647510781507 no 1259 0.305322639886195 1497 762578
SGTC_2545 solidagenone 89.61 µM 0.508944885462324 0.375711241835604 no 1260 0.305395428342195 1395 6708572 An anti ulcer agent
SGTC_293 4049-0273 38.5 µM 0.50792707104226 0.376023609371142 no 1261 0.305752244521309 1420 1380311
SGTC_3023 9089636 49.47 µM 0.506764848471222 0.37638039515618 no 1262 0.306159911627014 1539 17249241
SGTC_1436 4092-1007 8.32 µM 0.506317076879392 0.376517882870874 no 1263 0.306317038384149 1459 2881121
SGTC_2744 captopril 92.04 µM 0.503746895006713 0.377307356593441 no 1264 0.307219624902938 1562 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2536 dehydroabietamide 32.04 µM 0.502378108016402 0.377728011663077 no 1265 0.307700787708701 1601 3983547
SGTC_1053 3366-3204 134 µM 0.50190400514162 0.377873746615869 no 1266 0.307867523917079 1435 3632071 YPR165W RHO1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.500579763340163 0.378280898643296 no 1267 0.308333453749296 1451 688669
SGTC_504 lovastatin 124 µM 0.499852791727249 0.378504471198401 no 1268 0.308589367561833 1436 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2391 6285546 200 µM 0.499174592337533 0.378713081038628 no 1269 0.308828196084964 1451 846083
SGTC_3152 9099253 49.47 µM 0.498993423797148 0.378768813319234 no 1270 0.308892008438619 1519 25236131
SGTC_2195 6536160 144.242 µM 0.496658731584751 0.379487252179811 no 1271 0.309714864459192 1390 3834386
SGTC_2262 9014885 67.46 µM 0.495786699616778 0.379755703533347 no 1272 0.31002245486139 1470 6457424
SGTC_2038 4100038 30.985 µM 0.494262711741047 0.380224995850555 no 1273 0.31056032784631 1517 3596803
SGTC_313 3474-0040 5.03 µM 0.494072630646438 0.380283541245729 no 1274 0.310627443104765 1456 1043375 YIL048W NEO1
SGTC_1855 st056195 39.6 µM 0.492916137106182 0.380639802862304 no 1275 0.31103592229342 1557 4028379
SGTC_3077 9117319 49.47 µM 0.491766883176254 0.380993934592084 no 1276 0.311442075156195 1501 17154678
SGTC_554 4483-2211 187 µM 0.490656953767424 0.381336043492011 no 1277 0.311834548472142 1494 747107
SGTC_2229 7354935 190 µM 0.49054300767587 0.381371169873085 no 1278 0.311874852150988 1511 318112
SGTC_1695 st026914 34.495 µM 0.489871731348652 0.381578125346471 no 1279 0.312112333879089 1456 3289191
SGTC_111 0083-0039 52.457 µM 0.489736507872085 0.38161981904127 no 1280 0.312160182209264 1454 759313
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.489443395553663 0.381710199598139 no 1281 0.3122639098037 1405 641818 YHR062C RPP1
SGTC_759 3486-0358 89.3 µM 0.489154147162442 0.381799395043472 no 1282 0.312366284607376 1646 875103
SGTC_2024 5144227 134 µM 0.486441468566096 0.38263620779452 no 1283 0.313327097529599 1560 3475211
SGTC_276 colchicine 750 µM 0.48470794518608 0.383171256089731 no 1284 0.313941764878476 1542 2833 A microtubule depolymerizer.
SGTC_1141 3253-0389 52.6 µM 0.48187375397516 0.384046502973944 no 1285 0.314947815909401 1513 5402031
SGTC_987 1497-1013 404 µM 0.481632462318672 0.384121045372795 no 1286 0.315033530651533 1513 1676435
SGTC_871 0574-0004 149 µM 0.481082041007211 0.384291103448683 no 1287 0.315229095701611 1511 9551173
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.480698735927724 0.384409542480883 no 1288 0.31536531484039 1557 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3183 9108214 49.47 µM 0.480104806587683 0.3845930844932 no 1289 0.315576435302429 1478 4974831
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.479415982741191 0.384805984160182 no 1290 0.315821362743133 1495 2724 A muscle relaxant with antifungal properties.
SGTC_2987 9018338 71.43 µM 0.479154004015065 0.384886964903497 no 1291 0.315914536650127 1524 5055682
SGTC_2815 7968870 71.43 µM 0.477786556884656 0.385309740532108 no 1292 0.316401065097836 1475 2977326 YHR190W ERG9
SGTC_1765 st044815 90.4 µM 0.475244809509267 0.386095938178214 no 1293 0.317306245919894 1438 645695
SGTC_1061 3448-9325 110 µM 0.475115329406473 0.386136000720399 no 1294 0.317352386399165 1505 723482
SGTC_578 3460-0051 92 µM 0.474694440933269 0.38626623654547 no 1295 0.317502390408919 1554 2876744
SGTC_1707 st032323 6.317 µM 0.474377177349264 0.386364416117765 no 1296 0.317615482479417 1518 3132057 YMR211W DML1
SGTC_460 trequinsin 123 µM 0.474333974153998 0.386377786230384 no 1297 0.317630884047343 1530 5537 A vasodilator.
SGTC_542 3381-0244 89.3 µM 0.473425686007638 0.386658905787376 no 1298 0.317954754002914 1622 1112843
SGTC_821 1114-0266 29.2 µM 0.472305713554151 0.38700562454217 no 1299 0.318354296370091 1503 3123235
SGTC_2435 5706476 10.6 µM 0.471963030234082 0.387111729766476 no 1300 0.318476588511753 1588 5725375
SGTC_2688 kanamycin b 96.69 µM 0.47088426726759 0.38744580277719 no 1301 0.318861691793669 1511 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1769 st044406 64.4 µM 0.470276121333487 0.387634171125645 no 1302 0.319078877650818 1529 670903
SGTC_2602 kawain 100 µM 0.469584961534396 0.387848284468305 no 1303 0.319325785490712 1492 5369129
SGTC_2646 retinol 96.75 µM 0.467735550496789 0.388421378254734 no 1304 0.319986857416239 1543 445354 A vitamin A analog and teratogen.
SGTC_1998 st075797 76.8 µM 0.466364120654458 0.388846512652247 no 1305 0.32047744449123 1550 24208315
SGTC_2557 derrustone 83.84 µM 0.465760002467417 0.389033827663277 no 1306 0.320693648919003 1479 629853 An antioxidant.
SGTC_2087 5276107 200 µM 0.465243094700368 0.389194122384653 no 1307 0.320878690409059 1503 144405
SGTC_3014 9081533 49.47 µM 0.463601934933658 0.389703176051426 no 1308 0.321466483904716 1638 21367265
SGTC_2486 5283202 22.39 µM 0.462166318046611 0.390148629824814 no 1309 0.321981027592267 1490 1377751
SGTC_2999 9069765 71.4286 µM 0.461763772953951 0.390273560403802 no 1310 0.32212536630826 1590 2097066
SGTC_3130 9127414 49.47 µM 0.460764431692104 0.390583756686586 no 1311 0.322483811394467 1523 1494646
SGTC_1980 st071811 45.7 µM 0.460481874488774 0.390671475295453 no 1312 0.32258518934725 1582 4974850
SGTC_2131 toluylene red 5.2905 µM 0.457534507324806 0.391586803071305 no 1313 0.323643452687716 1478 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2912 7964298 10.93 µM 0.457516416479451 0.391592423183428 no 1314 0.323649952691255 1530 2975850
SGTC_1938 st074717 56.4 µM 0.456274221687703 0.391978378168706 no 1315 0.324096399309414 1476 17250979
SGTC_323 4013-0906 34.3 µM 0.455934577342368 0.392083925576054 no 1316 0.324218512069194 1622 2910086
SGTC_2000 st075254 36.4 µM 0.450424432916311 0.393797354672339 no 1317 0.326202215394463 1526 17234175
SGTC_2955 9076254 12.21 µM 0.450230157622917 0.39385780408154 no 1318 0.326272246556883 1631 16459619
SGTC_678 1218-2179 85.9 µM 0.449687310355385 0.394026726383192 no 1319 0.326467961265574 1583 6820081 YOR116C RPO31
SGTC_767 0929-0023 86 µM 0.447808906402853 0.394611398648378 no 1320 0.327145557543861 1549 1204563
SGTC_1397 3532-0190 20.1 µM 0.446079044580928 0.395150045758764 no 1321 0.327770074650037 1573 5322280
SGTC_1317 1273-0028 910 nM 0.443978596620629 0.395804355912425 no 1322 0.328529029211424 1551 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.442885370156845 0.39614502302876 no 1323 0.328924324924788 1553 4620898
SGTC_2348 9022543 33.42 µM 0.442514256745396 0.396260686041013 no 1324 0.329058557993374 1588 3162678 YDL140C RPO21
SGTC_1561 5-methoxyflavone 52.9 µM 0.442127039598161 0.396381377756565 no 1325 0.329198639343126 1576 94525
SGTC_17 0960-0276 49.807 µM 0.441566648727618 0.39655606357367 no 1326 0.329401411235182 1569 6821114
SGTC_324 1315-0088 19.6 µM 0.440990318253449 0.396735739765717 no 1327 0.329610003058041 1583 6787421
SGTC_3220 9131269 49.47 µM 0.440873736125823 0.396772087956713 no 1328 0.329652204184872 1572 17722206
SGTC_2764 methyldopa 94.69 µM 0.438583515132967 0.39748631878699 no 1329 0.33048167195453 1660 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_339 3091-4833 71.4 µM 0.438031154851942 0.397658630023331 no 1330 0.33068184962268 1608 3240077
SGTC_1874 staurosporine 7.6 µM 0.436366999554066 0.398177891224502 no 1331 0.331285239048344 1633 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_917 harmaline 728.087 nM 0.436284852422119 0.398203528017733 no 1332 0.331315035319038 1627 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_10 0279-0212 42.575 µM 0.435110352767092 0.398570118397291 no 1333 0.331741164580181 1554 39851 YBR002C RER2
SGTC_833 3852-0053 558 µM 0.434899331213732 0.398635992937121 no 1334 0.331817750032094 1635 3123681
SGTC_1736 st036774 51 µM 0.434825619383219 0.398659004219518 no 1335 0.331844503713573 1756 1272247
SGTC_1244 0416-0015 52.5 µM 0.434487790437555 0.398764471813871 no 1336 0.331967129573049 1563 96201
SGTC_1777 st045864 34.765 µM 0.433579042094539 0.399048212716044 no 1337 0.332297078257641 1578 4691462
SGTC_1003 4049-0218 100 µM 0.431272007630056 0.399768783512822 no 1338 0.333135300747588 1643 295161
SGTC_3307 9126885 69.2785 µM 0.431177699904385 0.399798246527928 no 1339 0.333169583663169 1519 24824909
SGTC_3181 9108277 49.47 µM 0.429872841118512 0.400205960630057 no 1340 0.333644071274382 1532 17097298
SGTC_748 act1.228 77.9 µM 0.429518489585873 0.400316699548002 no 1341 0.333772970606763 1515 4421505 YNR035C ARC35
SGTC_3150 9097574 49.47 µM 0.424386944349158 0.40192126040538 no 1342 0.335641820269381 1712 17217476
SGTC_910 3454-3003 490 µM 0.42429299800714 0.401950651588525 no 1343 0.335676072546599 1615 820824
SGTC_2438 5259590 200 µM 0.421991656356468 0.402670800810457 no 1344 0.336515553786348 1714 1201127
SGTC_1000 4048-0884 8.67 µM 0.421501279157542 0.402824295278258 no 1345 0.336694538661465 1623 13040088
SGTC_1334 1486-0610 236 µM 0.420712619965044 0.403071187312522 no 1346 0.336982472346362 1622 3742339
SGTC_522 1273-0010 11.6 µM 0.420126026401886 0.403254847187803 no 1347 0.337196695326258 1643 5705015
SGTC_2193 5925765 200 µM 0.419361057665061 0.403494387606557 no 1348 0.337476139934755 1644 877370
SGTC_1688 st021091 57.6 µM 0.415837187500422 0.404598309844398 no 1349 0.33876457246955 1712 3656366
SGTC_1836 st055642 81 µM 0.414110025407697 0.405139655672569 no 1350 0.339396765483029 1531 8571
SGTC_2268 7933382 153.85 µM 0.412589520831261 0.405616378976292 no 1351 0.339953690096211 1582 935025 YOR257W CDC31
SGTC_46 0329-0187a 2.197 µM 0.409596385080972 0.406555224361809 no 1352 0.34105102456883 1682 46494817
SGTC_367 0335-0881 7.1 µM 0.409298476204144 0.406648697787961 no 1353 0.341160316822642 1679 23828853
SGTC_2051 5263410 176 µM 0.408984521533435 0.406747211581608 no 1354 0.341275510135102 1642 227584
SGTC_2118 5526350 200 µM 0.407748347674242 0.407135159842431 no 1355 0.341729219184474 1662 743594
SGTC_1494 4358-1428 177 µM 0.407155017910505 0.407321396823371 no 1356 0.341947068444552 1754 1564571
SGTC_1993 st073995 70.8 µM 0.406940795288914 0.407388643121385 no 1357 0.342025736189889 1638 3098394
SGTC_2488 5268135 45.7 µM 0.40691050565543 0.40739815151455 no 1358 0.342036859831842 1673 1270356 YLR208W SEC13
SGTC_2290 7904846 200 µM 0.40461353687065 0.408119364766363 no 1359 0.342880803279529 1594 2962154
SGTC_1472 k841-0093 193 µM 0.404591769609436 0.408126200848481 no 1360 0.342888804682319 1700 X1472
SGTC_345 1362-0200 395 µM 0.403883402028903 0.408348681337861 no 1361 0.343149231157644 1570 1419823
SGTC_1683 st010134 710 nM 0.403077020187331 0.408601981605698 no 1362 0.34344578259432 1572 3818134
SGTC_3200 9114385 49.47 µM 0.401524100892973 0.409089891342095 no 1363 0.34401714881215 1568 17018030 YLR208W SEC13
SGTC_2343 7990716 14.84 µM 0.401021807085234 0.409247736585184 no 1364 0.344202034307433 1665 6456862
SGTC_529 4076-0302 30.3 µM 0.400696984676646 0.409349819484724 no 1365 0.344321615542687 1604 5816522
SGTC_374 0880-0231 82.3 µM 0.400040830906196 0.409556049615765 no 1366 0.344563221708919 1666 6833587
SGTC_2985 9022375 71.43 µM 0.399291611413786 0.409791561047861 no 1367 0.344839173696029 1621 4939335
SGTC_1079 idarubicin 2.36 µM 0.399009860155231 0.409880135833253 no 1368 0.344942969487873 1647 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3281 9140613 49.47 µM 0.398476391617085 0.410047856147529 no 1369 0.345139528659344 1538 16013766
SGTC_2453 5731132 22.18 µM 0.397144575862465 0.410466645309114 no 1370 0.345630425170142 1763 1362040
SGTC_1960 st011366 51.8 µM 0.397143084246134 0.410467114404863 no 1371 0.345630975113591 1614 3972846
SGTC_1794 st048918 76.9 µM 0.396046871682622 0.410811894925598 no 1372 0.346035225328403 1737 672303
SGTC_2679 rapamycin 1 nM 0.392873813012231 0.411810272171666 no 1373 0.347206341907304 1658 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2663 amphotericin b 100 µM 0.392657128251429 0.411878471185974 no 1374 0.347286369596506 1641 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3097 9117246 49.47 µM 0.390253630438798 0.412635122300208 no 1375 0.348174503907991 1620 16423892
SGTC_887 0885-0007 9.62 µM 0.386997549488159 0.413660694747952 no 1376 0.349379011055421 1718 5719458
SGTC_2839 9003951 25.97 µM 0.38674858072678 0.413739137131097 no 1377 0.349471173572869 1683 2990634
SGTC_1749 st037932 54.2 µM 0.386163964864978 0.413923345096923 no 1378 0.349687619815428 1624 594497
SGTC_1198 1612-1005 86.7 µM 0.385465694043466 0.414143389686588 no 1379 0.349946209333496 1736 6998509
SGTC_1076 itraconazole 331 nM 0.384470448498521 0.414457065857605 no 1380 0.350314897315548 1642 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_771 0250-0039 27.3 µM 0.3842328090413 0.414531971868563 no 1381 0.350402951558078 1659 3005115
SGTC_1316 1272-0050 65.9 µM 0.381611498466003 0.415358437276438 no 1382 0.351374777023312 1664 7340392
SGTC_851 0394-0702 453 µM 0.378800960880898 0.416244979624693 no 1383 0.352417836890265 1768 762646
SGTC_1402 3909-7673 35.9 µM 0.378697378944112 0.416277661181056 no 1384 0.352456299975598 1626 5328014
SGTC_847 0342-0274 5.54 µM 0.376360538283034 0.41701512066097 no 1385 0.353324439431852 1785 18097
SGTC_2936 9038235 15.59 µM 0.376034418419523 0.41711806075432 no 1386 0.353445654232641 1635 4749415
SGTC_2931 9014674 55.67 µM 0.375407030733471 0.417316112341129 no 1387 0.353678888430526 1591 2996810
SGTC_3151 9099821 49.47 µM 0.373772934679514 0.417832056528077 no 1388 0.354286628699689 1625 17174189
SGTC_2375 9072683 200 µM 0.372251155909014 0.418312665254528 no 1389 0.354852930733293 1817 16798029
SGTC_3088 9117578 49.47 µM 0.372108358324949 0.418357769911127 no 1390 0.354906086718688 1692 678341
SGTC_379 3970-0972 5.9 µM 0.370952582933141 0.418722877537022 no 1391 0.355336424615277 1696 2898042 YBL034C STU1
SGTC_2347 9049783 174.81 µM 0.370490094622913 0.418868996499552 no 1392 0.355508677832102 1730 6467988 YPL169C MEX67
SGTC_1663 st014140 55.4 µM 0.370073316464378 0.419000683345487 no 1393 0.355663931644364 1733 4207120
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.368881449147078 0.419377320409999 no 1394 0.356108045596262 1772 165506
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.368372159286457 0.41953828154388 no 1395 0.356297876922702 1663 15053
SGTC_1296 1068-0102 11.9 µM 0.364048187780098 0.420905413155271 no 1396 0.357911012997258 1751 767053
SGTC_2158 5657123 3.6195 µM 0.363996390415651 0.420921796003592 no 1397 0.357930352400275 1714 2858827
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.359870189118357 0.422227298685592 no 1398 0.359472105581358 1740 1377
SGTC_568 1193-0097 7.48 µM 0.358964526297979 0.422513959305655 no 1399 0.35981081348418 1721 3646150
SGTC_2345 9052315 157.45 µM 0.358861512748199 0.422546567782495 no 1400 0.359849346395648 1685 6469265
SGTC_1559 coumarin 343 70.1 µM 0.356853817537483 0.423182200406924 no 1401 0.36060062228571 1747 108770 A hepatotoxic, DNA x-linker.
SGTC_2103 5378138 10 µM 0.355903610556264 0.423483104026286 no 1402 0.360956375892642 1738 244142
SGTC_2357 9067248 200 µM 0.355837301736517 0.423504103818012 no 1403 0.360981206138275 1717 9150235
SGTC_3338 9144300 39.5675 µM 0.355172596826486 0.423714625739507 no 1404 0.361230146352492 1745 4901274
SGTC_3272 9137413 49.47 µM 0.355167135440027 0.423716355532019 no 1405 0.361232191952886 1597 17614870
SGTC_1480 1070-0044 41.2 µM 0.354902565596099 0.423800154865682 no 1406 0.361331293184412 1767 3124987
SGTC_2824 7998404 51.95 µM 0.354708752859962 0.423861544918808 no 1407 0.361403896482772 1716 837851
SGTC_2893 9048488 25.97 µM 0.354348241910491 0.423975741432484 no 1408 0.361538959108291 1613 6467338
SGTC_3073 9114972 49.47 µM 0.353886653440779 0.424121964878787 no 1409 0.361711914828914 1816 41905075
SGTC_2188 6126565 140.678 µM 0.352282781095014 0.424630125684738 no 1410 0.362313100103684 1754 874518
SGTC_63 0099-0242 26.702 µM 0.351063547010824 0.425016503999189 no 1411 0.362770337419206 1794 3898502 YLR359W ADE13
SGTC_1474 0330-0125 5.35 µM 0.350883207424537 0.425073660187627 no 1412 0.36283798502574 1681 X1474
SGTC_356 1634-0012 32.5 µM 0.350325166855883 0.425250533557087 no 1413 0.363047340045667 1867 735457
SGTC_479 n-linoleoylglycine 10 µM 0.350244554477709 0.425276085243238 no 1414 0.363077586045471 1687 6433346 An anti-infammatory.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.349476224770136 0.42551963826364 no 1415 0.363365908430588 1680 75037 A free radical scavenger.
SGTC_2855 9016525 58.44 µM 0.349374538786529 0.425551873859961 no 1416 0.363404072782744 1674 43811474
SGTC_2045 5106652 78.05 µM 0.34916558589863 0.42561811582869 no 1417 0.363482500349848 1778 673349
SGTC_1963 st076565 50.3 µM 0.349053986042763 0.425653495927899 no 1418 0.363524390151645 1679 4914280
SGTC_574 1315-0397 40 µM 0.348974972268273 0.425678545741383 no 1419 0.363554049522102 1694 6794277
SGTC_1861 st057647 17.4 µM 0.348750601349144 0.425749679906224 no 1420 0.363638276006581 1837 688668
SGTC_332 4112-0506 40.9 µM 0.347101473543694 0.426272590516393 no 1421 0.364257543258777 1727 2790355
SGTC_1764 st044502 93.5 µM 0.3469601074382 0.426317421369871 no 1422 0.364310644446702 1687 8407
SGTC_1105 epirubicin 18.1 µM 0.346509202332468 0.426460421416489 no 1423 0.364480034812429 1662 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1454 4239-0054 42.6 µM 0.34648440618383 0.42646828554777 no 1424 0.364489350686118 1814 1340767
SGTC_1242 0402-0103 60.1 µM 0.344645993480835 0.427051421790707 no 1425 0.36518026202423 1691 432868
SGTC_1438 4092-1045 4 µM 0.343592444569991 0.427385674721784 no 1426 0.36557640376036 1692 1351342
SGTC_2461 5755302 26.15 µM 0.336097404952733 0.429765070341822 no 1427 0.368398707632665 1839 2788904
SGTC_2148 5546263 113.568 µM 0.334659836958425 0.43022173908287 no 1428 0.368940850767299 1732 792097
SGTC_2360 9040895 200 µM 0.334086749800395 0.430403816351013 no 1429 0.369157049170273 1691 4914414
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.333690017212405 0.430529872141498 no 1430 0.369306741672746 1827 94937 An inhibitor of serotonin biosynthesis.
SGTC_2264 7948757 110.76 µM 0.333650664627383 0.430542376217433 no 1431 0.369321591009248 1672 2971411
SGTC_1102 cgs 12066b 26.1 µM 0.332139874733518 0.431022474265079 no 1432 0.36989182093243 1748 6438352 A 5-HT1B full agonist.
SGTC_182 3448-4371 550.524 µM 0.332060896227757 0.431047574824728 no 1433 0.369921638325104 1915 3491403
SGTC_2414 st077232 92.9 µM 0.33091554040146 0.431411617426973 no 1434 0.370354141571186 1630 729801
SGTC_1961 st076550 68.7 µM 0.330046221531233 0.43168796270415 no 1435 0.370682518666761 1745 1579337
SGTC_2455 5377712 9.75 µM 0.326572956036457 0.432792401426008 no 1436 0.371995450453158 1658 2243908
SGTC_1443 4112-3303 14 µM 0.322869063874481 0.433970753998751 no 1437 0.37339720302495 1732 704433
SGTC_3231 9132313 49.47 µM 0.322092836447392 0.434217776972124 no 1438 0.373691182518796 1764 4905967
SGTC_3262 9137218 49.47 µM 0.321862752556455 0.434291002729826 no 1439 0.373778335989911 1756 17650664
SGTC_746 1095-0025 46.6 µM 0.31973561972011 0.434968083623475 no 1440 0.374584377711114 1821 6749286
SGTC_742 0kpi-0133 140 µM 0.316628191913657 0.435957541426447 no 1441 0.375762870771302 1874 2728852
SGTC_2907 7721985 69.9 µM 0.316103572173532 0.436124628994925 no 1442 0.375961947727881 1695 3267881
SGTC_956 1185-0240 191 µM 0.315416629112085 0.436343432592118 no 1443 0.376222671274423 1767 1416193
SGTC_1667 st014849 34.6 µM 0.313750495579679 0.436874206584343 no 1444 0.376855272927962 1790 5348460
SGTC_2502 avocadyne acetate 18.59 µM 0.313570204500458 0.436931648077796 no 1445 0.376923746147251 1721 3952079
SGTC_1399 3562-5772 25 µM 0.312806153771173 0.437175092585809 no 1446 0.377213969907821 1750 23847490
SGTC_1168 k815-0004 80.5 µM 0.312727865008239 0.437200038569725 no 1447 0.37724371172214 1750 642433
SGTC_964 1287-0107 19.4 µM 0.312557710498493 0.437254257577701 no 1448 0.37730835574289 1862 51516812 YPR165W RHO1
SGTC_731 3966-0296 387 µM 0.311873147022374 0.437472402703458 no 1449 0.377568465474382 1761 660956
SGTC_74 000s-0487 160.283 µM 0.311801505060435 0.437495233453675 no 1450 0.377595690079669 1868 677548
SGTC_624 k048-0052 28 µM 0.310476947968609 0.437917378684757 no 1451 0.3780991434032 1766 6835531
SGTC_13 0199-0087 65 µM 0.310358550646364 0.437955116153231 no 1452 0.37814415535197 1808 4589825
SGTC_1708 st033234 31.827 µM 0.309807135490608 0.438130879347591 no 1453 0.378353812539129 1846 674664
SGTC_2801 7907800 81.82 µM 0.309526062181054 0.43822047596655 no 1454 0.378460695058984 1730 6620925
SGTC_1694 st024011 44.9 µM 0.308980775714187 0.438394303788053 no 1455 0.378668075275021 1780 2787533
SGTC_219 mitoxanthrone 164.414 µM 0.307268283384029 0.438940293619838 no 1456 0.379319587450478 1843 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_638 3970-0837 4.09 µM 0.306637600129811 0.439141402186012 no 1457 0.379559615348842 1741 4118451 YLR208W SEC13
SGTC_3254 9136651 49.47 µM 0.305656227001965 0.439454367899912 no 1458 0.3799332024597 1743 16454030
SGTC_1038 k292-0204 154 µM 0.303370063916356 0.440183585319095 no 1459 0.380803928440339 1725 4454212
SGTC_1039 k821-0043 94 µM 0.302101487293742 0.440588310902199 no 1460 0.381287349344954 1875 15992768
SGTC_304 1310-0298 97 µM 0.302002509491142 0.440619891310209 no 1461 0.381325074962356 1787 1550234
SGTC_1574 spiramycin 23.7 µM 0.301806108297793 0.440682557285 no 1462 0.381399937068124 1727 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1419 3993-2473 62.6 µM 0.299986364178588 0.441263255765499 no 1463 0.382093778357824 1811 704026
SGTC_3004 9076122 71.4286 µM 0.29961658041353 0.441381272929636 no 1464 0.382234817776482 1861 44782551
SGTC_844 0330-0132 15.3 µM 0.29898963244223 0.441581376407853 no 1465 0.382473978027581 1855 2828079
SGTC_815 1582-0027 36.9 µM 0.298707149757623 0.441671541504942 no 1466 0.38258175063694 1823 3128206
SGTC_1548 st061468 90.8 µM 0.294990718986427 0.442858061528974 no 1467 0.38400048479305 1892 390799
SGTC_2682 pyrogallin 40.03 µM 0.294473312643986 0.443023291291253 no 1468 0.384198126633092 1838 822798 An ATP competetive kinase inhibitor.
SGTC_516 3992-2719 87.3 µM 0.293222469354223 0.443422779416919 no 1469 0.384676055233764 1669 5350887 YDR037W KRS1
SGTC_175 3793-3120 23.7 µM 0.292181270198684 0.443755356316346 no 1470 0.38507401567055 1769 5322297
SGTC_2993 9054257 71.4286 µM 0.290233371741423 0.444377654759921 no 1471 0.385818853731124 1779 6470217 YGL055W OLE1
SGTC_1145 3546-0597 10.2 µM 0.289823503551843 0.444508613565481 no 1472 0.38597563299167 1805 875334
SGTC_2543 pimpinellin 60.67 µM 0.288858203444298 0.444817064799624 no 1473 0.386344944842651 1760 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_573 3702-0553 84.7 µM 0.288675034116485 0.444875598359829 no 1474 0.386415034791385 1793 1222756
SGTC_817 1391-0715 46 µM 0.288399297106415 0.444963715099585 no 1475 0.386520552855839 1746 1353946
SGTC_2741 miltefosine 3.04 µM 0.288211325275849 0.44502378645088 no 1476 0.386592490062113 1823 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_536 3852-0578 10.6 µM 0.287263414047697 0.445326735668272 no 1477 0.386955316973419 1920 2869208
SGTC_309 k408-0051 1.48 µM 0.285314248181754 0.445949782618177 no 1478 0.387701698928305 1816 3640463
SGTC_2657 nystatin 74.44 µM 0.285080101274759 0.446024636217398 no 1479 0.387791387331512 1850 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2327 6189656 200 µM 0.283739596124029 0.446453214536246 no 1480 0.388304973959929 1903 5349088
SGTC_277 nystatin 15.5 µM 0.283178355489063 0.446632669654946 no 1481 0.388520059694079 1751 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2891 9063876 19.48 µM 0.283030057236643 0.446680089432182 no 1482 0.388576898138497 1970 6472478
SGTC_1426 4048-4480 71.7 µM 0.282560677987426 0.446830182935482 no 1483 0.388756813391573 1880 14224343
SGTC_2710 st078562 53.7235 µM 0.280800593367643 0.447393073228387 no 1484 0.389431674243278 1800 17250908
SGTC_2784 7567673 72.73 µM 0.279949440731315 0.447665317292865 no 1485 0.389758147435072 1794 3471247
SGTC_2252 omeprazole 400 µM 0.276716767162967 0.448699522503413 no 1486 0.390998798050306 1895 4594 A proton pump inhibitor.
SGTC_597 k018-0003 82.8 µM 0.276289744477539 0.448836162919964 no 1487 0.391162766097363 1910 6786234
SGTC_2032 5185112 25.99 µM 0.275214979798429 0.449180097218422 no 1488 0.391575539488716 1869 5718189
SGTC_857 0438-0306 1.35 µM 0.274716599461191 0.449339596354107 no 1489 0.391766988570045 1852 4686136
SGTC_1609 st001574 46.4 µM 0.273633393653202 0.449686288288088 no 1490 0.392183184327856 1774 3960012
SGTC_2292 7671323 168.05 µM 0.273379117227469 0.449767677831209 no 1491 0.392280901821133 1811 937504
SGTC_1828 st055811 49 µM 0.272641946273275 0.450003645600477 no 1492 0.392564232274298 1959 5877589
SGTC_834 0312-0008 75.7 µM 0.272546809943027 0.450034099945162 no 1493 0.392600801919751 1812 6385573 YIL048W NEO1
SGTC_1718 roemerine 11.9335 µM 0.272499189057705 0.450049344104428 no 1494 0.392619107363832 1856 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2113 5491891 107.031 µM 0.272364905713308 0.450092330612854 no 1495 0.392670727092288 1746 789979
SGTC_2942 9052777 62.25 µM 0.271796589138996 0.450274265424783 no 1496 0.392889214001435 1817 6469503
SGTC_288 1315-0019 35.1 µM 0.271506768319859 0.450367049599366 no 1497 0.393000647391432 1843 6811474
SGTC_1187 1391-0724 117 µM 0.270648071823342 0.450641971380117 no 1498 0.393330859596078 1849 6997986
SGTC_2218 6965428 192.983 µM 0.267141513951647 0.451764881549138 no 1499 0.394680102576149 1914 675684
SGTC_1539 benzyladenosine 56 µM 0.264964555003862 0.452462207098548 no 1500 0.395518383586272 1835 92208 A nucleotide analog.
SGTC_3224 9130643 49.47 µM 0.264179985474851 0.452713557216019 no 1501 0.395820616330419 1888 17644395
SGTC_375 3970-0961 9.27 µM 0.264093999561696 0.452741105411506 no 1502 0.395853743731708 1854 2898222
SGTC_2013 4024628 200 µM 0.264013031927165 0.452767046057169 no 1503 0.395884938451345 1886 5230760
SGTC_751 0833-0568 350 µM 0.26027185576081 0.453965872980026 no 1504 0.397327040259219 1864 6954252
SGTC_2026 5148700 152 µM 0.259918002676228 0.454079283969374 no 1505 0.397463512139415 1826 79838
SGTC_1733 st037357 54.9 µM 0.259741226400666 0.454135942706183 no 1506 0.397531694828336 1719 1272339 YGL099W LSG1
SGTC_2387 9077560 195.08 µM 0.259642726934546 0.454167513271298 no 1507 0.397569687475036 1818 5303272
SGTC_3044 9093193 49.47 µM 0.256211694912737 0.455267390131025 no 1508 0.398893689362083 1782 25236277
SGTC_1529 apigenin 74 µM 0.255903236031829 0.455366288906878 no 1509 0.39901277790774 1970 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1865 st057639 52.2 µM 0.254236383466127 0.455900766609004 no 1510 0.399656471928779 1926 688818
SGTC_1841 st054148 70 µM 0.25367554375355 0.456080618336198 no 1511 0.399873114701019 1812 675442
SGTC_1036 k216-0215 33.5 µM 0.25340717948201 0.456166681365074 no 1512 0.399976790128845 1791 622330
SGTC_1042 0350-0096 82 µM 0.252609303077437 0.456422568317315 no 1513 0.400285070159657 1801 3122515
SGTC_1206 3978-0017 132 µM 0.251366463131614 0.456821195496264 no 1514 0.400765396994784 1922 3873677
SGTC_3333 9141820 12.094 µM 0.248707185285499 0.457674274933718 no 1515 0.401793645200708 1829 1939433
SGTC_1047 2043-3044 82 µM 0.248364943125437 0.457784078292668 no 1516 0.4019260276308 1810 669592
SGTC_1936 st074407 74.3 µM 0.246733833961235 0.458307439786693 no 1517 0.402557110096235 1797 809813
SGTC_686 1319-0111 510 µM 0.246352199748413 0.458429902299836 no 1518 0.402704802583484 1971 4562600
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.246254233311242 0.458461339363825 no 1519 0.402742717847343 1818 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3230 9131665 49.47 µM 0.24519425315889 0.458801499610942 no 1520 0.403153012958335 1898 15943720
SGTC_3087 9117406 49.47 µM 0.243320960280893 0.459402735210395 no 1521 0.403878384140102 1872 42546093
SGTC_1992 st073643 23.3 µM 0.243262628832428 0.459421458256752 no 1522 0.403900976400576 1858 3161292
SGTC_348 k064-0012 10.7 µM 0.241481029568829 0.459993353587195 no 1523 0.404591158857611 1833 5066323
SGTC_970 1315-0089 19.5 µM 0.239318146491746 0.460687752580495 no 1524 0.405429447657264 1887 6811083 YLR033W RSC58
SGTC_2658 polymyxin b sulfate 77.05 µM 0.239176810654016 0.460733132999178 no 1525 0.40548424165591 1881 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1782 st039423 80.636 µM 0.238599764351689 0.460918417583098 no 1526 0.405707973935513 1826 2068169
SGTC_353 1988-1175 58.3 µM 0.238449446893838 0.460966684615177 no 1527 0.4057662600514 1813 2788357
SGTC_1366 1683-0113 21.9 µM 0.237884984369088 0.461147939021992 no 1528 0.405985150996396 1842 708623
SGTC_2649 anisomycin 9.56 µM 0.237737450842514 0.461195314804339 no 1529 0.406042367353856 1906 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_172 1112-0046 2.638 µM 0.237334085317924 0.46132484584854 no 1530 0.406198810553044 1872 2802135 YIL048W NEO1
SGTC_816 0325-0417 81.3 µM 0.237265872139671 0.461346751260441 no 1531 0.406225268157032 1871 68101
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.23610843555598 0.461718458627776 no 1532 0.406674264169532 1844 6708561
SGTC_3013 9080133 71.4286 µM 0.235697786916136 0.461850345288975 no 1533 0.40683359365268 1924 17050193
SGTC_865 0488-0499 301 µM 0.233662765702673 0.462503987926425 no 1534 0.407623398123732 2036 9634651
SGTC_1522 st012842 45.6 µM 0.232957500758021 0.462730540605062 no 1535 0.407897203672466 1784 3491067 YOR116C RPO31
SGTC_2419 paclitaxel 166.5 µM 0.23190676193554 0.46306809246536 no 1536 0.408305216213438 1889 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2088 5278280 127.392 µM 0.230709351044029 0.463452795416748 no 1537 0.408770304204682 1917 791502
SGTC_2395 5646831 180.19 µM 0.230663263974373 0.463467602908903 no 1538 0.408788207518164 1935 6808628
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.227065194672798 0.464623795057545 no 1539 0.410186523908173 2035 1273210
SGTC_605 1315-0399 119 µM 0.226680382176284 0.464747467338531 no 1540 0.410336141406105 1953 24020461
SGTC_1977 st070720 65.3 µM 0.226257571911261 0.464883355391056 no 1541 0.410500547720946 1882 682188
SGTC_296 1222-0039 74.9 µM 0.226085286970787 0.464938727655921 no 1542 0.410567543823351 1868 5984176
SGTC_906 1165-0455 526 µM 0.226050974359891 0.464949755787269 no 1543 0.410580887211843 1866 3252859
SGTC_1469 k284-2957 126 µM 0.224738498983889 0.465371607731098 no 1544 0.411091356378856 1962 23884841
SGTC_2041 5107442 45.335 µM 0.224154211004844 0.465559420388454 no 1545 0.411318655609534 2005 793005
SGTC_2832 7992762 51.95 µM 0.223843388005228 0.465659333998934 no 1546 0.411439583854027 1703 2985177
SGTC_2298 7976326 193.81 µM 0.21802704585027 0.467529381328561 no 1547 0.41370401937425 1991 2235818
SGTC_1899 st063254 59.6 µM 0.217460192470435 0.467711672786452 no 1548 0.413924863246871 1835 3093813
SGTC_2899 9053889 58.44 µM 0.217002559347323 0.46785884560649 no 1549 0.414103175196963 2062 6470052
SGTC_2304 7443016 91.4 µM 0.216499684966596 0.468020572883519 no 1550 0.414299135348696 1912 939854
SGTC_3242 9133940 49.47 µM 0.215130403184172 0.468460968412522 no 1551 0.414832825249747 1987 17248444
SGTC_3263 9137018 49.47 µM 0.214038761615301 0.46881209553 no 1552 0.415258415068958 1828 43844957
SGTC_278 4092-0821 23.9 µM 0.212774213333187 0.469218868498624 no 1553 0.415751538981769 1988 877900
SGTC_423 5-fluorouracil 457 µM 0.211567649379507 0.469607019347113 no 1554 0.416222175017832 1794 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_94 0334-0113 514.748 µM 0.210522577748583 0.469943241576853 no 1555 0.416629915994515 1834 6795178
SGTC_1821 st053465 65.6 µM 0.207250517459661 0.470996071897062 no 1556 0.417907108213451 1913 675086
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.206892370550398 0.471111323025245 no 1557 0.418046957516142 1956 97141
SGTC_2427 5545055 42.75 µM 0.206863806177863 0.471120515100991 no 1558 0.418058111786549 1956 5372858
SGTC_365 0121-0052 13.6 µM 0.206144993321425 0.471351835656997 no 1559 0.418338826936332 1977 3101739
SGTC_1028 k015-0029 4.8 µM 0.205263395491466 0.471635555095833 no 1560 0.418683170642673 1895 4588309
SGTC_2869 9037858 32.47 µM 0.2050496987182 0.471704330043197 no 1561 0.418766647958099 2065 27187042
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.204102643012215 0.472009135162988 no 1562 0.419136644493288 1972 521171
SGTC_1871 st057448 67.3 µM 0.203992494956099 0.472044586828988 no 1563 0.41917968187958 2018 691747
SGTC_2828 7998861 71.43 µM 0.203755751428734 0.472120784587563 no 1564 0.419272186308876 2060 2988188
SGTC_75 0159-0059 199.013 µM 0.203427894746546 0.472226309513096 no 1565 0.419400299376605 2032 5377270
SGTC_3253 9135987 49.47 µM 0.202881728666211 0.472402104475289 no 1566 0.419613737852505 2000 4182430
SGTC_2127 5253358 187.912 µM 0.202139706578131 0.472640948392041 no 1567 0.419903753581796 1916 20612
SGTC_1025 k007-0731 70 µM 0.201991880148966 0.472688532308916 no 1568 0.419961536025252 1857 6256118
SGTC_3069 9117009 49.47 µM 0.201841506080796 0.472736936686373 no 1569 0.420020316060931 2068 41904981
SGTC_1575 cyproterone acetate 48 µM 0.201260784719407 0.472923870668496 no 1570 0.420247332192354 1894 9880 An androgen receptor antagonist and liver toxin.
SGTC_100 0086-0128 49.5915 µM 0.199852007200293 0.473377380307823 no 1571 0.420798162920237 1850 93297
SGTC_3120 9124077 49.47 µM 0.198733112266409 0.473737596389075 no 1572 0.421235760388489 2080 18774327 YGL155W CDC43
SGTC_2362 9071156 126 µM 0.19868997057612 0.47375148581992 no 1573 0.421252634965156 2029 653133
SGTC_3211 9128781 49.47 µM 0.198061008389529 0.473953983281034 no 1574 0.421498665627473 1830 17194361
SGTC_2265 7929201 200 µM 0.197984330468114 0.473978670575233 no 1575 0.421528661769921 1988 1265108
SGTC_992 3909-8734 162 µM 0.197871237044442 0.474015082420436 no 1576 0.421572904364256 1911 4288319
SGTC_1636 st007707 68.9 µM 0.19785041382229 0.474021786741469 no 1577 0.42158105059901 2043 403051
SGTC_1325 1431-0015 227 µM 0.197663586414724 0.47408193870824 no 1578 0.421654140688753 1866 1103340
SGTC_253 dyclonine 31.25 µM 0.197639943628197 0.474089550910339 no 1579 0.421663390345252 1985 3180 An oral anasthetic.
SGTC_2972 9093619 59.92 µM 0.195853214220626 0.474664846371226 no 1580 0.42236252880954 1857 25236256
SGTC_133 0724-0033 378.92 µM 0.193768755074157 0.475336072260834 no 1581 0.423178476567793 2073 280309
SGTC_2567 aureobasidin a 60 nM 0.193590387290947 0.475393512536345 no 1582 0.423248312816248 1973 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1684 st024538 14.6195 µM 0.192480126317212 0.475751064431665 no 1583 0.42368306687556 1920 6732859
SGTC_2788 5282734 71.43 µM 0.192200212304227 0.475841211904034 no 1584 0.423792689803899 2054 743706
SGTC_389 tpck 16.7 µM 0.191286346466923 0.476135534783689 no 1585 0.424150628762458 1947 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3171 9103192 49.47 µM 0.191156567951999 0.47617733277302 no 1586 0.424201464922304 2102 13018434
SGTC_2702 st077768 96.8 µM 0.189649927399971 0.476662598152128 no 1587 0.424791730359076 1931 6484119
SGTC_490 phenamil 164 µM 0.189307301035578 0.476772957606464 no 1588 0.424925986694867 2069 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2234 tolnaftate 200 µM 0.188069834108353 0.477171558681528 no 1589 0.425410954004626 2073 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1389 3405-0187 19 µM 0.186405626242614 0.477707653429723 no 1590 0.426063340326412 1902 799890
SGTC_777 1315-0167 517 µM 0.185456839345047 0.478013306248389 no 1591 0.426435365096231 1924 4221767
SGTC_642 0335-0876 158 µM 0.185350350927422 0.47804761242833 no 1592 0.42647712390612 1965 6812350
SGTC_2773 thioridazine 9.09 µM 0.185172846757409 0.478104797318668 no 1593 0.42654673295957 2104 5452 An antipsychotic.
SGTC_2288 7946289 167.31 µM 0.183428448719005 0.478666797833349 no 1594 0.427230927840986 2063 1246052
SGTC_1446 4239-0190 62 µM 0.18341118609983 0.478672359622356 no 1595 0.42723769975302 1930 1340085
SGTC_1336 1486-0901 104 µM 0.181270487463664 0.47936209643419 no 1596 0.428077634924507 2004 5006114
SGTC_2310 7668677 200 µM 0.180050891414853 0.479755080163987 no 1597 0.428556307708054 2028 2197143
SGTC_531 3788-1495 174 µM 0.179168261935497 0.480039497305209 no 1598 0.428902791878078 1933 2896655
SGTC_448 monastrol 171 µM 0.178948835077041 0.480110206655359 no 1599 0.428988938387186 2070 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2117 5521686 200 µM 0.178601088533037 0.480222267746728 no 1600 0.429125469853571 1953 803312
SGTC_2620 irigenin 100 µM 0.178297294378872 0.480320166489386 no 1601 0.429244751771996 2052 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2406 ethylparaben 405.7 µM 0.175682830592063 0.481162735157327 no 1602 0.430271562351611 1728 8434 A possible steroid mimic.
SGTC_2940 9060638 45.86 µM 0.174997045159686 0.481383758736991 no 1603 0.430540977690317 1977 4027022
SGTC_2151 5563267 85.4165 µM 0.173136108829939 0.481983553409507 no 1604 0.431272221390512 1984 5310824
SGTC_3035 9091303 49.47 µM 0.17264769466651 0.482140980014918 no 1605 0.431464179927165 2069 25237002
SGTC_2473 5854593 8.94 µM 0.171866964038779 0.482392632406333 no 1606 0.431771059479173 1959 2872951
SGTC_2919 7978188 46.38 µM 0.171715794629192 0.482441359556822 no 1607 0.431830483970458 2103 2980291
SGTC_2747 doxorubicin 7.63 µM 0.17094984576758 0.482688255490768 no 1608 0.432131601117735 2123 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1285 0929-0069 65.5 µM 0.170819868110984 0.482730153146337 no 1609 0.432182703096114 1991 1206237
SGTC_1126 isoteolin 1.0172 µM 0.170176063413318 0.482937683213423 no 1610 0.432435837879488 1983 133323
SGTC_2714 st079313 56.9 µM 0.168383015146323 0.483515695462617 no 1611 0.433140984637395 1998 2939799
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.16811595081844 0.483601790089195 no 1612 0.433246030503774 2113 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3260 9137109 49.47 µM 0.164143790760799 0.484882399742069 no 1613 0.434808974629013 2129 17478346
SGTC_40 0327-0103 19.753 µM 0.164083181738359 0.484901941107279 no 1614 0.434832830697183 1996 409036
SGTC_2280 7785178 200 µM 0.16378993381554 0.484996489666465 no 1615 0.434948258155949 2008 2954328
SGTC_2595 hexamethylquercetagetin 100 µM 0.16359707184144 0.48505867239749 no 1616 0.435024174990342 2015 386331
SGTC_2515 chrysin 20.77 µM 0.16356315456632 0.485069608073428 no 1617 0.435037526196306 2092 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_62 0180-0423 3.232 µM 0.162039511502512 0.485560875587474 no 1618 0.435637369664195 2064 30102 YGL099W LSG1
SGTC_2520 obtusaquinone 4.71 µM 0.161252517549733 0.485814634306765 no 1619 0.435947259631147 2114 5967872
SGTC_2448 5185112 27.17 µM 0.159570260954002 0.486357081087742 no 1620 0.436609803536471 1998 5718189
SGTC_2829 7992743 58.44 µM 0.159421620071886 0.486405011846231 no 1621 0.436668353191494 2170 16462845
SGTC_1955 wogonin 32.4 µM 0.158612329720013 0.486665979147597 no 1622 0.436987157032734 2098 5281703 A flavanone.
SGTC_1266 0828-0227 32.9 µM 0.157734905859015 0.486948923525809 no 1623 0.437332846947219 2051 3913820
SGTC_1653 st012112 65 µM 0.156422985220382 0.487371993036944 no 1624 0.437849810295082 2112 720429
SGTC_1371 2421-0008 32.7 µM 0.154772531842501 0.487904253059973 no 1625 0.438500323325043 1996 2827552
SGTC_333 3486-0131 40.1 µM 0.15476452739607 0.487906834492935 no 1626 0.43850347862009 2138 6744690
SGTC_1391 3442-0225 151 µM 0.154742665301947 0.487913885018106 no 1627 0.43851209651982 2029 5227075
SGTC_184 1494-0393 24.714 µM 0.154721021507402 0.487920865145385 no 1628 0.438520628395951 2007 3090647
SGTC_154 3389-1638 511.116 µM 0.154407341653869 0.488022027363757 no 1629 0.438644282639292 1886 5238686
SGTC_890 0929-0006 47.2 µM 0.153935868616204 0.488174079565858 no 1630 0.438830151045927 1965 1378169
SGTC_2694 st077685 81.9 µM 0.15380595388332 0.488215977961968 no 1631 0.43888136959084 2033 2838096
SGTC_3238 9133470 49.47 µM 0.153750814024604 0.488233760985506 no 1632 0.43890310864588 2142 3534688
SGTC_1262 0737-0114 49.6 µM 0.153699446252559 0.488250327503469 no 1633 0.438923360710231 2149 765919
SGTC_2063 5246145 200 µM 0.151789791266496 0.488866220675411 no 1634 0.43967636711111 2081 711240
SGTC_752 1896-0090 130 µM 0.15118395294332 0.489061618491711 no 1635 0.439915304243438 2096 772567
SGTC_230 MPP+ 141.667 µM 0.148577560025776 0.489902273909616 no 1636 0.440943490476352 2002 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3075 9116269 49.47 µM 0.147794900610742 0.490154718635902 no 1637 0.441252316932752 2059 17015205 YNL244C SUI1
SGTC_1303 1160-0052 261 µM 0.147105486480672 0.490377090612297 no 1638 0.441524379704374 2162 3562476
SGTC_131 0141-0277 33.849 µM 0.147025312488151 0.490402951097527 no 1639 0.441556020475997 2130 1547771
SGTC_928 2764-0428 58.7 µM 0.145591265430107 0.490865516196707 no 1640 0.442122031843418 2063 662578
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.145446268660871 0.490912286935598 no 1641 0.442179267957899 2143 6728940
SGTC_1465 k213-0056 144 µM 0.144584194261215 0.491190363666263 no 1642 0.442519588622816 2011 24048857 YMR208W ERG12
SGTC_1840 st055363 71 µM 0.143927681280111 0.491402135951292 no 1643 0.442778788380123 1977 676033
SGTC_1137 ixabepilone 100 µM 0.141135777871906 0.492302750375121 no 1644 0.443881339936095 2078 154225 A novel microtubule stabilizer.
SGTC_1398 3558-0053 112 µM 0.140046225419242 0.492654229970364 no 1645 0.444311733820848 2057 4532369
SGTC_2624 nerol 100 µM 0.136146660757341 0.493912238459081 no 1646 0.445852670482252 2113 637566 A natural product oil.
SGTC_2621 lithochol-11-enic acid 100 µM 0.134526187337895 0.494435025419401 no 1647 0.446493252397174 2183 6708711
SGTC_283 0987-0079 11.7 µM 0.13340388248448 0.494797102020677 no 1648 0.446936987537883 2147 411556
SGTC_2318 6029776 164 µM 0.133184974591704 0.494867726322706 no 1649 0.447023546759523 2101 818325
SGTC_2964 9083345 53.42 µM 0.133167853723914 0.494873249882471 no 1650 0.447030316694933 2059 17741579
SGTC_1701 st028638 40.4 µM 0.132926297893911 0.49495118108696 no 1651 0.447125834371827 2164 3490878
SGTC_2059 5238311 157 µM 0.132629763322658 0.495046849901391 no 1652 0.447243096315828 2075 703021
SGTC_880 0833-0487 87.2 µM 0.132116779995744 0.495212350689481 no 1653 0.447445961868598 2140 76075
SGTC_2890 9046729 58.44 µM 0.131743542155212 0.495332766734244 no 1654 0.447593571997824 2031 903329
SGTC_1987 st072290 61.9 µM 0.13161849388845 0.495373110589429 no 1655 0.447643028390129 2061 54697379
SGTC_213 1246-0773 967 nM 0.131031698261961 0.495562426895677 no 1656 0.44787511599448 2102 6251622
SGTC_2850 9015429 58.44 µM 0.129618921522095 0.49601823130078 no 1657 0.448433966165976 2092 6457570
SGTC_2256 7954252 200 µM 0.129002450981733 0.496217124962369 no 1658 0.448677854716451 2053 2972920
SGTC_2859 9028643 45.46 µM 0.128320520342585 0.496437139297044 no 1659 0.448947663232974 2130 17151580
SGTC_2175 5807670 165.306 µM 0.127147378927029 0.496815637661504 no 1660 0.449411876386667 2171 241186
SGTC_322 k048-0136 19.3 µM 0.127010510247411 0.496859796700997 no 1661 0.449466039973886 2124 6823282
SGTC_869 0564-0080 44.1 µM 0.125727790683053 0.497273652595317 no 1662 0.449973701318549 2013 6843321
SGTC_1144 3486-0183 12.5 µM 0.125234699095336 0.497432744183495 no 1663 0.450168873786463 2093 6744069
SGTC_102 gallobenzophenone 83.616 µM 0.124832268029001 0.497562585269485 no 1664 0.450328170501039 2180 70837
SGTC_2439 5492030 7.2 µM 0.124203181413429 0.497765555423295 no 1665 0.450577201671078 2195 5722370
SGTC_1618 st003135 44.5 µM 0.124031144510382 0.49782106196335 no 1666 0.450645307849646 2185 1270615
SGTC_1652 st011932 78 µM 0.1228069907573 0.498216028024561 no 1667 0.451129969172019 2178 1551076
SGTC_543 3844-1095 191 µM 0.122740575261194 0.498237456650111 no 1668 0.451156266180062 2134 4230703
SGTC_1753 st043925 64 µM 0.121954159920908 0.498491189971254 no 1669 0.451467661141169 2181 670181
SGTC_782 0083-0095 30.5 µM 0.121277693807338 0.498709449168231 no 1670 0.451735543677384 2222 3591729 An indicator and reagent.
SGTC_978 1416-0512 87.4 µM 0.120687180307161 0.498899976402205 no 1671 0.45196940670107 2092 6814003
SGTC_990 3985-0011 41.3 µM 0.120597947865968 0.498928766978057 no 1672 0.452004747172841 2128 5399565 YGL099W LSG1
SGTC_3276 9139060 49.47 µM 0.119297911597252 0.49934822028341 no 1673 0.452519668994501 2221 4870619
SGTC_776 4476-4378 112 µM 0.119141263883341 0.499398762316831 no 1674 0.452581719846004 2045 2892008
SGTC_2544 sphondin 68.51 µM 0.118779116004325 0.499515608553023 no 1675 0.45272517727541 2176 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_520 3584-0023 682 µM 0.118322278309629 0.499663006313116 no 1676 0.45290615292658 2011 1340790
SGTC_2023 5144124 124 µM 0.117800045751601 0.499831503649044 no 1677 0.453113046648085 2108 2830192
SGTC_1087 pterostilbene 9.05 µM 0.117385930803296 0.499965117067842 no 1678 0.453277116291475 2185 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1321 1326-2144 215 µM 0.117169701875711 0.499965117067842 no 1679 0.453362787954531 2191 3513030
SGTC_1331 1472-0049 76.2 µM 0.117031797459037 0.499920622462803 no 1680 0.453417427941982 2146 24051409
SGTC_1735 st034310 56.75 µM 0.116606952122348 0.499783546909128 no 1681 0.453585764157986 2121 871153
SGTC_65 0798-0905 34.986 µM 0.116569730535423 0.499771537434672 no 1682 0.453600512843081 2185 3602145
SGTC_3323 9138564 53.9225 µM 0.115498142989186 0.499425791876416 no 1683 0.454025146153848 2199 43912313 YNL103W MET4
SGTC_1971 st069429 63.5 µM 0.114905541439072 0.499234590351321 no 1684 0.45425999637897 2208 1246522 YGL099W LSG1
SGTC_647 0140-0236 81 µM 0.113357668150731 0.498735173541034 no 1685 0.454873499623309 2133 990837
SGTC_607 4491-0986 66.8 µM 0.112908035323025 0.49859010115498 no 1686 0.455051732902352 2189 698981 YDR232W HEM1
SGTC_1346 1488-2224 62.4 µM 0.112860567879873 0.49857478596874 no 1687 0.455070549401564 2210 3722427
SGTC_1717 st033143 58.0435 µM 0.112070495098888 0.498319872379141 no 1688 0.455383755759012 2187 674616
SGTC_1074 carmofur 3.8 µM 0.111881711763178 0.498258962344286 no 1689 0.455458598724652 2207 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3096 9117468 49.47 µM 0.111872557576536 0.498256008791036 no 1690 0.455462227933046 2212 41316311
SGTC_2145 5634607 200 µM 0.110729665533686 0.497887261103784 no 1691 0.455915360467379 2109 308662
SGTC_2988 9073640 71.4286 µM 0.109943655592221 0.497633660447133 no 1692 0.45622703011108 2159 9102229
SGTC_1018 4259-0013 28.1 µM 0.109910023215196 0.49762280921453 no 1693 0.456240366665485 2109 6801262
SGTC_1516 st013856 110 µM 0.109892265420216 0.497617079796717 no 1694 0.45624740834641 2138 5281404 A mutagen and neurotoxin.
SGTC_3271 9137798 49.47 µM 0.109359536952534 0.497445199232565 no 1695 0.456458663019867 2202 6498326
SGTC_2876 9059903 25.97 µM 0.109266662529656 0.497415234093127 no 1696 0.456495493842958 2216 6916095
SGTC_2720 fluspirilene 36.88 µM 0.108544936677877 0.497182375920233 no 1697 0.456781718371848 2183 3396 An atypical antipsychotic.
SGTC_1223 0764-0573 147 µM 0.107242206972119 0.496762064710018 no 1698 0.457298416080732 2181 1609797
SGTC_1385 3091-4834 14.1 µM 0.106835998819395 0.496631006893186 no 1699 0.457459543986426 2152 4072814
SGTC_2311 7694451 200 µM 0.105428207692454 0.496176804162545 no 1700 0.45801801714184 2161 2163142
SGTC_2090 5301565 104.445 µM 0.105116441843583 0.49607621822858 no 1701 0.458141706439022 2140 2056344
SGTC_204 PMA1.184 62.41 µM 0.104602508805753 0.495910407046615 no 1702 0.458345611945196 2238 2252213 YGL008C PMA1
SGTC_797 k781-0471 270 µM 0.104540193428378 0.495890302166743 no 1703 0.458370336629424 2159 23738129
SGTC_2875 9039966 71.43 µM 0.103396401532316 0.495521281215114 no 1704 0.458824184001103 2190 6463691
SGTC_1375 2910-0797 186 µM 0.103351201036611 0.495506698280634 no 1705 0.458842120298533 2145 742508
SGTC_1956 st077085 54 µM 0.10277197257103 0.495319823639099 no 1706 0.459071975049952 2124 24208685
SGTC_1659 st012954 42.1 µM 0.102285182227359 0.495162772808026 no 1707 0.459265158243295 2183 24207262
SGTC_1964 st076914 61 µM 0.101876523711887 0.495030929851374 no 1708 0.459427342178141 2241 24208661
SGTC_2774 tamoxifen 10.92 µM 0.101594730366201 0.494940016931171 no 1709 0.459539181182961 2206 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1689 st020265 53.493 µM 0.100465802745357 0.494575801976194 no 1710 0.459987265449582 2219 5758320 YPR016C TIF6
SGTC_3350 9150499 3.57 µM 0.0992919802404913 0.494197107819792 no 1711 0.460453222896381 2233 4910996 YPR165W RHO1
SGTC_2165 5727197 32.143 µM 0.098338863744244 0.493889620828559 no 1712 0.460831609458163 2129 1361712
SGTC_259 usnic acid 108.925 µM 0.0980769722685482 0.4938051320766 no 1713 0.460935586411228 2213 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2129 girgensonine 121.053 µM 0.0971914468672222 0.493519455000331 no 1714 0.461287180149939 2158 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1651 st011928 86.1 µM 0.0962466287553546 0.493214653323447 no 1715 0.461662349145229 2191 720198
SGTC_1553 gossypol 38.6 µM 0.0952948331143837 0.492907604676885 no 1716 0.462040323278148 2223 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2781 5567276 71.43 µM 0.0949145655661651 0.492784931781056 no 1717 0.462191343551459 2207 2853274
SGTC_225 nsc-122657 1.016 µM 0.0947701706339997 0.492738350691445 no 1718 0.462248690294932 2203 275685
SGTC_1097 itavastatin 7.23 µM 0.0904107683415741 0.491332078645985 no 1719 0.463980399920282 2247 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1760 st045453 10.4495 µM 0.0892540968380625 0.49095897265855 no 1720 0.464439986913109 2246 3323419 YIL048W NEO1
SGTC_415 dibenzyl ketone 100 µM 0.0878695186096281 0.490512361532359 no 1721 0.464990191747296 2227 7593
SGTC_3126 9127922 49.47 µM 0.0876379091188563 0.490437654458017 no 1722 0.465082235481092 2181 45595682
SGTC_2030 5175110 200 µM 0.0873434498313599 0.490342675277546 no 1723 0.465199258996904 2200 2831986
SGTC_1817 st052116 64.4 µM 0.0866750405869277 0.490127078880934 no 1724 0.465464908231398 2232 4361398
SGTC_1547 harmine 94.2 µM 0.0858686645430844 0.489866984932715 no 1725 0.465785410775092 2241 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2933 9026794 32.47 µM 0.0842597864062337 0.489348059550761 no 1726 0.466424942228496 2209 17586027
SGTC_70 0141-0289 43.283 µM 0.0840396818021511 0.48927706869138 no 1727 0.466512440915044 2144 352408
SGTC_482 fipronil 114 µM 0.0836823634061651 0.489161822667012 no 1728 0.466654489958691 2262 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_725 1497-0963 19 µM 0.0835755408527369 0.489127369327613 no 1729 0.466696957227951 2257 3549977
SGTC_2190 6049624 200 µM 0.0834367790253551 0.489082614776856 no 1730 0.466752122510606 2236 2265554
SGTC_795 0685-0265 78 µM 0.0813611143084829 0.488413171864707 no 1731 0.467577386417345 2295 302754
SGTC_2881 9058953 51.95 µM 0.0812893161764455 0.48839001612075 no 1732 0.467605935163875 2241 17122249
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0805557194024348 0.488153424769799 no 1733 0.467897641250014 2187 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3010 9080089 71.4286 µM 0.0805077309495325 0.488137948220017 no 1734 0.467916723893516 2258 17027233
SGTC_2529 gangaleoidin 93.61 µM 0.0783027581204929 0.487426851548357 no 1735 0.468793611769275 2226 4565183
SGTC_925 2064-1272 59.6 µM 0.0773681678497251 0.487125461111384 no 1736 0.469165331616292 2082 6815817
SGTC_775 4577-0580 57.3 µM 0.0773248390622 0.487111488446387 no 1737 0.469182565673201 2219 2006902
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0772587218877911 0.487090167014149 no 1738 0.469208863938919 2295 229346 A bile salt which induces apoptosis.
SGTC_3310 9130229 44.1445 µM 0.0764538199642279 0.486830605634975 no 1739 0.469529026359929 2250 7761258
SGTC_1948 st076329 66.6 µM 0.0762513987256448 0.486765330560859 no 1740 0.469609545705261 2287 24208413
SGTC_3250 9135583 49.47 µM 0.0760922500360514 0.486714009898062 no 1741 0.469672852920802 2284 7699353
SGTC_1818 st052136 56.3 µM 0.0757146445077837 0.48659224436118 no 1742 0.469823062403169 2197 674169
SGTC_3123 9126162 49.47 µM 0.0754842696533889 0.486517956555054 no 1743 0.46991470641269 2271 25239884
SGTC_1250 0485-0349 40.2 µM 0.0747035346566224 0.486266200411118 no 1744 0.470225297642494 2206 6842794 YDL195W SEC31
SGTC_1513 0337-0559 19 µM 0.0740377950354751 0.486051530045305 no 1745 0.470490155841689 2111 775073
SGTC_1215 3852-0577 11.2 µM 0.0734791411044163 0.485871392998968 no 1746 0.470712421092861 2255 2884876
SGTC_425 3825-7017 13.1 µM 0.0729077803833741 0.485687161651359 no 1747 0.470939751286416 2204 3397440
SGTC_3042 9091578 49.47 µM 0.0703185371127831 0.484852316779123 no 1748 0.471970064272573 2268 25236497
SGTC_3208 9114115 49.47 µM 0.0700090763291958 0.484752542286579 no 1749 0.472093217749583 2124 650895
SGTC_1809 st050081 57.6 µM 0.0693361354738994 0.484535580029597 no 1750 0.472361031494064 2247 5036894
SGTC_1103 duloxetine 36.1 µM 0.0692187354102785 0.484497729647716 no 1751 0.472407755086759 2257 60835 A selective serotonin reuptake inhibitor.
SGTC_1545 lovastatin 49.4 µM 0.068926714800363 0.48440358131382 no 1752 0.47252397687396 2224 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_290 2043-6722 48.1 µM 0.0687024789308521 0.48433128757655 no 1753 0.472613222483541 2258 773758 YLR208W SEC13
SGTC_2205 7238770 200 µM 0.0679197571860782 0.484078941813861 no 1754 0.472924755554418 2289 279867
SGTC_496 calpeptin 138 µM 0.0666566214103895 0.483671726347739 no 1755 0.473427534282802 2172 73364 A calpain inhibitor.
SGTC_2662 daunorubicin 22.37 µM 0.0653852643231458 0.483261877656134 no 1756 0.473933628169476 2262 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1662 st014054 52 µM 0.0646519398584501 0.483025483109287 no 1757 0.474225564575856 2293 2838777
SGTC_2768 sulfasalazine 50.2 µM 0.0641630911117285 0.48286790108865 no 1758 0.474420182918417 2296 5384001 An antioxidant and salicylic acid derivative.
SGTC_3145 9085516 49.47 µM 0.0635606119117474 0.482673693597513 no 1759 0.474660047717058 2112 25236195
SGTC_598 3937-0236 20.2 µM 0.0619510958030289 0.482154890852369 no 1760 0.475300888520748 2256 1379313
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0617279201161554 0.482082955970248 no 1761 0.475389752661688 2266 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2738 aclarubicin 5.55 µM 0.0616604367391535 0.482061204572378 no 1762 0.475416623447891 2268 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_843 0310-0051 143 µM 0.0615233807736674 0.482017028541594 no 1763 0.475471197254435 2183 2065037
SGTC_615 k087-0205 167 µM 0.0613820541909578 0.481971476231964 no 1764 0.475527472044108 2268 9642773
SGTC_1902 st060212 70.5 µM 0.060710101988803 0.481754896182556 no 1765 0.475795043149744 2313 688944
SGTC_1680 diphenhydramine 100 µM 0.0597063154912518 0.481431371122687 no 1766 0.476194770838259 2154 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1283 0922-0125 16.4 µM 0.0593115349304883 0.48130413484935 no 1767 0.476351986872282 2277 3360884
SGTC_1888 azatryptophan 97.5 µM 0.0586933779250648 0.481104909028083 no 1768 0.476598166948497 2191 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3017 9080681 49.47 µM 0.0581158075342532 0.480918768130368 no 1769 0.476828191541322 2222 16451914
SGTC_1567 st069303 68.4 µM 0.0574151315258448 0.480692958020665 no 1770 0.477107254835516 2227 5581319
SGTC_654 1124-0271 80.9 µM 0.0568830334109506 0.480521480426012 no 1771 0.477319184901974 2254 5403748
SGTC_3216 9129716 49.47 µM 0.0551054210214811 0.47994864115674 no 1772 0.478027238679268 2279 8056934
SGTC_1789 tunicamycin 25 nM 0.0549978193941824 0.479913967627035 no 1773 0.478070100518303 2283 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3177 9107506 49.47 µM 0.0549561685615334 0.479900546110739 no 1774 0.478086691704324 2304 8897194
SGTC_1424 4048-1941 275 µM 0.0544769157778431 0.479746113889687 no 1775 0.478277599906875 2305 X1424
SGTC_1351 1496-0003 46.5 µM 0.0540588500679948 0.479611400792899 no 1776 0.478444138584209 2293 3891978
SGTC_2351 9026858 72.31 µM 0.0524557351073315 0.479094851612096 no 1777 0.479082782506145 2303 1409300
SGTC_1232 0279-0259 161 µM 0.0502608071903363 0.478387667984352 no 1778 0.479957277802619 2275 1560000
SGTC_2675 theaflavin digallate 100 µM 0.0498412813004641 0.47825250865256 no 1779 0.480124434912182 2312 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2009 4012297 12.05 µM 0.0490910318558968 0.478010805826362 no 1780 0.480423375167091 2242 45595307
SGTC_123 0083-0120 66.675 µM 0.0489119936091521 0.477953127468477 no 1781 0.480494715392767 2286 16001701
SGTC_940 3232-1287 54.8 µM 0.0464467969695392 0.477158995506104 no 1782 0.481477069074045 2337 1585493 YIL048W NEO1
SGTC_870 0573-2213 57.6 µM 0.0459647454959585 0.47700371921479 no 1783 0.481669174606743 2326 3916321
SGTC_813 k007-0158 173 µM 0.045008038505306 0.476695559348596 no 1784 0.482050450824145 2303 6523916
SGTC_1623 st003709 20.3 µM 0.0448232437838631 0.476636037691218 no 1785 0.482124098924754 2324 16192618
SGTC_3124 9127567 49.47 µM 0.0447500514678179 0.476612462876388 no 1786 0.482153269164071 2327 17592030
SGTC_3086 9117350 49.47 µM 0.0446063053862535 0.476566163346669 no 1787 0.482210558346452 2336 2679265
SGTC_1350 1495-0454 146 µM 0.0441795425052721 0.476428708104656 no 1788 0.482380644422482 2313 1069057
SGTC_416 estradiol valerate 100 µM 0.0429847192649209 0.476043884737769 no 1789 0.482856857427542 2243 13791 A steroid.
SGTC_3043 9092303 49.47 µM 0.0427473024919917 0.475967421246662 no 1790 0.482951486036376 2302 25236084
SGTC_2390 9097792 176.6 µM 0.042695546728075 0.475950752674875 no 1791 0.482972114765308 2267 4497149
SGTC_29 0299-0004 12.984 µM 0.0408489359240452 0.475356057016642 no 1792 0.48370816333279 2327 16871 A napthoquinone isolated from Swertia calycina.
SGTC_702 1488-0190 94 µM 0.0399848230893429 0.475077790756563 no 1793 0.48405261301852 2334 949357
SGTC_2911 7942208 15.64 µM 0.0381859634113379 0.474498551443391 no 1794 0.484769706154624 2289 1243384
SGTC_48 0382-0018 55 µM 0.0354922855948852 0.473631278626458 no 1795 0.485843598852432 2353 762596
SGTC_1063 disulfiram 1.84 µM 0.0351503286527141 0.473521188952799 no 1796 0.485979934861501 2342 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2263 7948595 193.29 µM 0.0343242079595107 0.473255235882768 no 1797 0.486309310540252 2353 2971371
SGTC_2834 9001755 58.44 µM 0.0331573579822579 0.472879612157519 no 1798 0.486774551404793 2238 2989575
SGTC_382 3229-0966 23.2 µM 0.0326048345971204 0.472701756303512 no 1799 0.486994857215407 2335 5722370
SGTC_1771 st048882 4.1505 µM 0.0321997768928191 0.472571372727652 no 1800 0.487156367050945 2328 4580403
SGTC_2818 7996756 12.99 µM 0.0321816834006775 0.472565548701973 no 1801 0.487163581570994 2341 2241621
SGTC_1132 3456-3614 2.5 µM 0.0307358858782593 0.472100187075088 no 1802 0.487740085940554 2350 3125502
SGTC_2130 NSC 7 2.4545 µM 0.0304136571181333 0.471996475852329 no 1803 0.487868576544758 2328 21448
SGTC_873 0591-4978 488 µM 0.0296676442320095 0.471756374512999 no 1804 0.488166058359726 2347 3305145
SGTC_3235 9132602 49.47 µM 0.0287491580882046 0.471460777435228 no 1805 0.488532325033584 2304 4912240
SGTC_2153 5569715 200 µM 0.02776329635267 0.471143514318393 no 1806 0.488925469968989 2360 2054701
SGTC_700 3453-2283 142 µM 0.0270290259665724 0.470907228454913 no 1807 0.489218291555483 2331 565664
SGTC_3239 9133757 49.47 µM 0.0266193213145418 0.470775391253549 no 1808 0.489381681269523 2355 17036923
SGTC_1383 3049-0032 20.7 µM 0.0263957398734205 0.470703447236692 no 1809 0.489470846028039 2342 712864
SGTC_83 0170-0301 39.027 µM 0.0258217949504775 0.470518767672259 no 1810 0.489699738893545 2355 3089716
SGTC_559 1550-0661 158 µM 0.0243986315837984 0.470060860593974 no 1811 0.490267319919947 2332 5830875
SGTC_2879 9041815 71.43 µM 0.0224537927408037 0.469435167002634 no 1812 0.491042985373849 2367 4942971
SGTC_2302 7771753 200 µM 0.0224182579271464 0.46942373543906 no 1813 0.491057158145883 2330 2203047
SGTC_1807 st050092 58.9 µM 0.0208761572961507 0.468927665466028 no 1814 0.491672223100196 2351 5008496
SGTC_3065 9113888 49.47 µM 0.0193613978175243 0.468440437674571 no 1815 0.492276402355363 2360 16648368
SGTC_2224 6650123 117.647 µM 0.0192375525042394 0.468400604467983 no 1816 0.492325800286557 2372 2908370
SGTC_2364 9055074 200 µM 0.0170834186326523 0.467707806759376 no 1817 0.493185033498846 2368 6470630
SGTC_2847 9005661 71.43 µM 0.0149886578005158 0.467034197972489 no 1818 0.494020614565729 2380 2991449
SGTC_1068 loratadine 26.9 µM 0.0149129922583478 0.467009868083851 no 1819 0.494050797376134 2346 3957 A H1 histamine antagonist.
SGTC_257 daunorubicin 18.5 µM 0.0146403617120892 0.466922206074866 no 1820 0.494159549353974 2366 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_812 4251-0442 148 µM 0.014602676184173 0.466910088743382 no 1821 0.494174582097416 2382 5723007
SGTC_2380 9035439 200 µM 0.0145749082998144 0.466901160331376 no 1822 0.494185658701728 2339 6462575
SGTC_1711 st032263 62.8 µM 0.0142625352616324 0.466800721880423 no 1823 0.494310264559986 2350 3958979
SGTC_2442 5158906 48.48 µM 0.0139865990877939 0.466712000866678 no 1824 0.494420336185694 2371 1893835
SGTC_1939 st074455 53.6 µM 0.012822727620782 0.46633780266575 no 1825 0.494884611983064 2385 1644229
SGTC_2797 7859098 81.82 µM 0.0123856899401383 0.466197297639586 no 1826 0.495058950941791 2372 972681
SGTC_3110 9122132 49.47 µM 0.0123703637616295 0.466192370440318 no 1827 0.495065064734013 2373 918317
SGTC_2625 euphol 100 µM 0.0120802952461475 0.466099117553548 no 1828 0.495180776681245 2390 6708538 A triterpene alcohol.
SGTC_2284 7945075 39.21 µM 0.0110901976811528 0.465780829370646 no 1829 0.495575741938913 2383 1245402
SGTC_974 1326-0144 138 µM 0.010688715660613 0.465651770555358 no 1830 0.495735900594542 2377 5411856
SGTC_1128 3448-9350 235 µM 0.010004611220085 0.465431869388979 no 1831 0.496008804166733 2352 619386
SGTC_3190 9110366 49.47 µM 0.00950304400904603 0.465270650395338 no 1832 0.496208891013509 2393 17123768
SGTC_1127 asiatic acid 681.4 nM 0.00726022445735632 0.464549809917927 no 1833 0.497103614943936 2390 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2552 juarezic acid 87.02 µM 0.0068588614320058 0.464420824354437 no 1834 0.497263731633534 2391 1549512
SGTC_2597 laccaic acid a 100 µM 0.0058785545844226 0.464105800041497 no 1835 0.497654809535916 2383 5491415 A textile dye.
SGTC_939 1165-0479 45.3 µM 0.00413056990101011 0.463544136295286 no 1836 0.498352145710175 2399 1377347
SGTC_2413 inermin 26.06 µM 0.00218902873064978 0.462920364050731 no 1837 0.49912670458378 2397 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2924 9010168 62.78 µM 0 0.462217189191152 no 1838 0.5 2405 2993929
SGTC_2096 5468907 200 µM -2.86413620330501e-05 0.462207989593664 no 1839 0.499988573749718 2407 759785
SGTC_3309 9129340 25.759 µM -0.00144460017464048 0.461753209322819 no 1840 0.499423688112509 2407 17158987
SGTC_212 3807-4682 38.772 µM -0.00177220947926515 0.461647994261748 no 1841 0.49929299107908 2406 3125501 YBL034C STU1
SGTC_473 2-arachidonoylglycerol 10 µM -0.00182157153023804 0.461632141369398 no 1842 0.499273298501693 2388 5282280 An endocannabinoid.
SGTC_1945 st075991 56.6 µM -0.00192104293431068 0.461600195769759 no 1843 0.499233615222416 2413 1084980
SGTC_359 0081-0058 15.9 µM -0.00218783484688302 0.461514515810188 no 1844 0.499127180873352 2413 3494159
SGTC_1257 0669-0121 16 µM -0.00601309832532499 0.460286234555278 no 1845 0.497601135297925 2427 4307855
SGTC_2431 5490079 200 µM -0.00682707791093705 0.460024916508948 no 1846 0.497276411127038 2418 5722345
SGTC_726 3448-4391 34.2 µM -0.00800347908931273 0.459647278045648 no 1847 0.496807107888145 2417 1356692
SGTC_3018 9082602 49.47 µM -0.0105888529717799 0.45881747134007 no 1848 0.49577573778881 2408 17332089
SGTC_2761 levamisole 97.89 µM -0.0111943751892555 0.458623147532012 no 1849 0.495534183706101 2431 26879 An alkaline phosphatase inhibitor.
SGTC_830 4076-0286 57.8 µM -0.0116423903305524 0.458479377157126 no 1850 0.495355463176596 2436 6866659
SGTC_707 0865-0008 204 µM -0.0122735310080205 0.458276850070589 no 1851 0.495103692480996 2432 723043
SGTC_196 k015-0023 18.111 µM -0.0133413993736716 0.457934205884848 no 1852 0.49467770959894 2427 5211998
SGTC_2976 9009005 19.48 µM -0.0138483202888007 0.45777156239614 no 1853 0.494475496102674 2423 2993148
SGTC_316 k060-0003 58.6 µM -0.0152753036425879 0.457313758719344 no 1854 0.493906272511807 2440 6152314
SGTC_2514 salinomycin 42.74 µM -0.0155226347865746 0.457234415878451 no 1855 0.493807613359592 2435 23682228 A polyether potassium ionophore.
SGTC_2506 ethyl hematommate 54.16 µM -0.017414309441132 0.456627630827363 no 1856 0.493053046801769 2462 3940691 An allergen.
SGTC_2326 6164455 177.58 µM -0.0176819986435817 0.456541773347507 no 1857 0.492946270702683 2458 2888790
SGTC_2713 st079149 53.4 µM -0.0182769792896089 0.456350949094049 no 1858 0.492708946132573 2456 3103253
SGTC_1467 k284-1082 293 µM -0.0196221775514211 0.455919549624422 no 1859 0.492172386055257 2447 3334705
SGTC_1202 1988-0068 29.6 µM -0.0207192766847568 0.455567752957222 no 1860 0.491734795874758 2449 2850480
SGTC_503 tyrphostin 8 294 µM -0.0210704149029859 0.455455164047131 no 1861 0.491594742570555 2443 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2163 5671233 125 µM -0.0214057820861237 0.455347635299522 no 1862 0.491460980592897 2443 701023
SGTC_2162 5663267 200 µM -0.0223328056367927 0.455050420869974 no 1863 0.491091240144561 2452 6456493
SGTC_693 4161-2696 114 µM -0.0225557698534387 0.454978939720689 no 1864 0.491002312692956 2469 805759
SGTC_2793 7325131 81.82 µM -0.0231648847139046 0.454783668153707 no 1865 0.490759374512631 2466 4176441
SGTC_791 1348-1292 225 µM -0.024653548430992 0.454306474689291 no 1866 0.490165653394175 2525 5437054
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0246844953415341 0.454296555306422 no 1867 0.490153311119195 2432 279621
SGTC_1616 st002734 56.1 µM -0.0248008580381438 0.454259257940597 no 1868 0.490106903327283 2468 4026101
SGTC_845 0330-0138 4.51 µM -0.0250318224171723 0.454185228856319 no 1869 0.490014790468802 2436 9039800
SGTC_937 3122-0005 46.7 µM -0.0257749974274476 0.453947035986815 no 1870 0.489718402192317 2450 759535
SGTC_1827 berberine 7.24 µM -0.0276211881729374 0.453355390601148 no 1871 0.488982141196604 2458 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_38 0929-0051 58.268 µM -0.0280492541168994 0.45321822382345 no 1872 0.488811433738902 2478 1379719
SGTC_2080 5212524 12.4 µM -0.0284115091370908 0.453102149446666 no 1873 0.488666972471844 2455 260183
SGTC_2046 4110841 106 µM -0.0295617798320946 0.452733604340438 no 1874 0.488208273628709 2462 44119630 YMR134W ERG29
SGTC_398 bronopol 33.3 µM -0.0300722669044882 0.452570058028641 no 1875 0.488004709264203 2465 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0318008486162357 0.452016326910286 no 1876 0.487315434941062 2472 5106787 A p450 inhibitor.
SGTC_3106 9121286 49.47 µM -0.0320191590919792 0.451946400294976 no 1877 0.487228385992214 2591 15943471
SGTC_3297 9117502 71.43 µM -0.0326499311381405 0.45174436727843 no 1878 0.486976875872028 2453 7453720
SGTC_2216 7189485 200 µM -0.0329354554079015 0.45165291944055 no 1879 0.486863029398599 2471 731273
SGTC_3020 9089140 49.47 µM -0.035767235422227 0.450746095365999 no 1880 0.485733979343626 2492 17217859
SGTC_357 1325-0123 420 µM -0.0365452449192544 0.450496997326853 no 1881 0.485423801278614 2462 1098503
SGTC_1343 1487-0095 224 µM -0.0366567059326365 0.450461312056409 no 1882 0.485379364542177 2468 4560101 YGL055W OLE1
SGTC_1186 1319-0216 26 µM -0.03899458164197 0.449712912339607 no 1883 0.484447354276562 2496 4565136
SGTC_1138 3761-0006 1.03 µM -0.0395584423954024 0.449532436155892 no 1884 0.484222579825138 2460 12061087
SGTC_1184 1269-1718 139 µM -0.0396759594984002 0.449494823504885 no 1885 0.484175734061281 2506 5403821
SGTC_701 4424-0219 185 µM -0.0407824771028532 0.449140692582031 no 1886 0.483734654491171 2484 2911779
SGTC_595 3909-8003 73.7 µM -0.0408352029705756 0.449123819155233 no 1887 0.483713637421066 2509 699517
SGTC_1432 4049-0298 68.4 µM -0.0412917586810835 0.448977715228492 no 1888 0.483531651544216 2495 741646
SGTC_289 k017-0060 526 µM -0.0415363238566017 0.448899453949396 no 1889 0.483434167789792 2495 5512909
SGTC_1341 1486-1360 280 µM -0.0421959715485961 0.448688375469212 no 1890 0.483171236970246 2486 3976547
SGTC_904 1141-0088 396 µM -0.0436527123596348 0.44822228933696 no 1891 0.482590616663096 2497 1378119
SGTC_2518 prenyletin 46.28 µM -0.0438689756855193 0.448153101679179 no 1892 0.482504422649655 2503 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2756 carbadox 75.1 µM -0.0442644116802776 0.448026596605572 no 1893 0.482346819610073 2510 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_392 N-ethylmaleimide 8.33 µM -0.045367787427004 0.447673640467392 no 1894 0.481907078224133 2505 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1210 3013-0140 750 nM -0.0475918218214608 0.446962325803606 no 1895 0.481020774943342 2518 905973
SGTC_1757 st041620 31.8375 µM -0.0481329751178528 0.446789274036896 no 1896 0.480805133154466 2522 5289815
SGTC_69 0096-0274 206.684 µM -0.0482027671031742 0.446766956465038 no 1897 0.480777322461818 2743 6741392
SGTC_1017 4239-0030 168 µM -0.0482507761795532 0.446751604570743 no 1898 0.480758191871519 2514 1149593
SGTC_2596 sinensetin 100 µM -0.0498131118448277 0.446252059138383 no 1899 0.480135658957153 2530 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1755 st041960 45.185 µM -0.0510675141797577 0.445851034836582 no 1900 0.479635861065607 2539 2257073
SGTC_251 melphalan 456.522 µM -0.0520283694387575 0.44554389307468 no 1901 0.47925304423875 2532 460612 A DNA alkylator.
SGTC_1224 0823-0416 294 µM -0.0520302794290268 0.445543282570072 no 1902 0.479252283293533 2550 3598164
SGTC_3009 9080819 71.4286 µM -0.0525785483130992 0.445368040592339 no 1903 0.479033854645096 2547 17027216
SGTC_1581 himbacine 57.9 µM -0.0526768375827295 0.445336625736582 no 1904 0.478994697164042 2493 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1627 st003713 25.6 µM -0.0539542404200634 0.444928378217913 no 1905 0.478485810978271 2544 16195070 YER133W GLC7
SGTC_1485 3909-9022 254 µM -0.0540108708033573 0.444910280958558 no 1906 0.478463251618281 2493 714516
SGTC_604 1000-0114 314 µM -0.0562238830295381 0.444203163314005 no 1907 0.477581727673204 2512 1572745
SGTC_510 ag-490 170 µM -0.0577976126595982 0.443700421764293 no 1908 0.476954919911818 2505 5328779
SGTC_2854 9024559 71.43 µM -0.0586130099465241 0.443439971624084 no 1909 0.476630174030405 2558 3163529
SGTC_916 4466-0038 42 nM -0.0600654897643254 0.442976088348891 no 1910 0.476051737746872 2524 5722064 YGL116W CDC20
SGTC_1587 estradiol valerate 56.1 µM -0.060455193970824 0.442851640500709 no 1911 0.475896550285777 2521 13791 A steroid.
SGTC_3056 9094900 49.47 µM -0.0625270587241908 0.442190107726784 no 1912 0.475071557173883 2555 25236784
SGTC_385 1494-0393 12.4 µM -0.0627796831594126 0.442109457395847 no 1913 0.474970972220092 2548 3090647
SGTC_2002 4023503 131 µM -0.0630983018839986 0.44200774181532 no 1914 0.474844113253338 2509 4736863 YCR052W RSC6
SGTC_2324 6149169 200 µM -0.0631837752837598 0.441980456007392 no 1915 0.474810082205326 2551 2888231
SGTC_969 1313-0238 134 µM -0.064489375515642 0.441563701484193 no 1916 0.474290283306527 2526 5212874
SGTC_2669 eugenol 100 µM -0.0675085133111633 0.440600225181755 no 1917 0.473088442423175 2505 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2740 felodipine 17.08 µM -0.0679867704467738 0.440447634439121 no 1918 0.472898082785235 2558 3333 L-type calcium channel blocker
SGTC_626 0214-0009 33 µM -0.0683300849797276 0.440338103376056 no 1919 0.472761437868989 2595 3437874
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0685963088103231 0.440253170471603 no 1920 0.472655478545209 2602 688751
SGTC_2953 9074162 66.49 µM -0.0707470360538038 0.439567129013606 no 1921 0.471799542619039 2545 16451992
SGTC_1239 0337-0584 35.4 µM -0.0745099047893105 0.438367282437179 no 1922 0.470302330097003 2614 914301 YML130C ERO1
SGTC_2221 6807166 181.081 µM -0.0752780242728147 0.43812242537074 no 1923 0.469996752976228 2549 674925
SGTC_3116 9124943 49.47 µM -0.079677766140542 0.436720358147802 no 1924 0.468246771635006 2554 41905195 YPL160W CDC60
SGTC_1784 st039334 36.3 µM -0.0797452910940307 0.43669884609404 no 1925 0.468219918523108 2743 3496984
SGTC_1062 mesoridazine 14.2 µM -0.0803046955081448 0.436520638621282 no 1926 0.46799746190104 2535 4078 A neuroleptic.
SGTC_2370 9071495 200 µM -0.0813583313225408 0.43618502062378 no 1927 0.467578492999577 2610 21791103
SGTC_719 2810-4230 27.3 µM -0.0833379236359302 0.435554579162037 no 1928 0.466791423229476 2562 721079
SGTC_2426 5582046 32.21 µM -0.0847960119915489 0.435090325882513 no 1929 0.46621178204619 2640 2251934
SGTC_2070 5230947 200 µM -0.0866554253515462 0.434498421158281 no 1930 0.465472704245692 2551 2835538
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0869080060895377 0.434418028743911 no 1931 0.465372317831319 2643 7104
SGTC_1437 4092-1038 11.6 µM -0.0878691064017138 0.434112150686499 no 1932 0.464990355560836 2565 3977136
SGTC_1228 0124-0032 52.5 µM -0.0885388663698068 0.433899017394195 no 1933 0.464724197360989 2602 X1228
SGTC_2697 mebhydrolin 72.4 µM -0.0892963485477127 0.433657992001899 no 1934 0.464423197957733 2627 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_564 3555-0129 330 µM -0.0906056963253259 0.433241425158811 no 1935 0.463902952770036 2567 563260
SGTC_936 3005-4620 401 µM -0.0944873151622513 0.432006932045684 no 1936 0.462361029198898 2580 777207
SGTC_2558 carylophyllene oxide 100 µM -0.094878689019461 0.431882497841181 no 1937 0.462205591922235 2553 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1269 0831-0796 3.05 µM -0.0976891274549744 0.430989140534468 no 1938 0.461089574647163 2632 927758
SGTC_1304 1165-0502 251 µM -0.102105708109153 0.429585951835679 no 1939 0.459336385140743 2618 767425
SGTC_3328 9140624 29.0385 µM -0.102421473947723 0.429485663942423 no 1940 0.459211069777836 2640 4904392
SGTC_137 0438-0332 85.389 µM -0.102485953737691 0.429465185585051 no 1941 0.459185480717597 2572 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3296 9122258 64.045 µM -0.102541747577072 0.429447465981652 no 1942 0.459163338847739 2670 4730474
SGTC_958 1222-0007 33 µM -0.103701104678748 0.429079297188623 no 1943 0.458703274988219 2711 7312461
SGTC_1429 4049-0205 9.46 µM -0.105264912736797 0.428582787564224 no 1944 0.458082801917114 2573 22774478
SGTC_3048 9093155 49.47 µM -0.106643163595564 0.428145286083163 no 1945 0.457536037110688 2583 25236002
SGTC_1219 1469-0211 33.1 µM -0.107697708515093 0.427810598960483 no 1946 0.457117743641006 2603 6822282
SGTC_1423 4048-0112 5.59 µM -0.108189027493188 0.427654683887229 no 1947 0.456922874329152 2667 X1423
SGTC_740 k014-0057 261 µM -0.108491669222846 0.42755864923791 no 1948 0.456802844253355 2704 4012779
SGTC_49 0717-0965 32.132 µM -0.109724740445421 0.427167413972989 no 1949 0.456313839422166 2879 5889349 YGL099W LSG1
SGTC_698 k064-0052 127 µM -0.110349529302701 0.426969205023822 no 1950 0.456066089185243 2569 5088751
SGTC_165 k038-0023 64.381 µM -0.11066933403544 0.426867756824221 no 1951 0.455939282229732 2623 46368543
SGTC_2751 anetholtrithion 17.25 µM -0.111259185785466 0.426680657220801 no 1952 0.455705409716142 2705 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2093 5331342 194.4 µM -0.111954866064221 0.426460010258909 no 1953 0.455429596587035 2682 33839
SGTC_454 lyso-paf C-16 6.67 µM -0.112632140431506 0.426245223156847 no 1954 0.455161101398887 2663 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1690 st023502 41.2 µM -0.11448704785885 0.425657080104681 no 1955 0.454425856599632 2639 24207482
SGTC_2798 7813637 45.45 µM -0.118532180212096 0.424375048770583 no 1956 0.45282299934727 2713 956368
SGTC_986 1493-0483 84 µM -0.119171380706459 0.424172538589427 no 1957 0.452569789964835 2604 40079
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.120181261775979 0.423852630972904 no 1958 0.452169780557996 2936 5282309
SGTC_2932 9016711 44.54 µM -0.121154461562665 0.423544390634107 no 1959 0.451784346372569 2660 7117328
SGTC_1932 st074806 40.9 µM -0.121700711736331 0.423371397992741 no 1960 0.451568024772525 2855 17251235
SGTC_1866 st057638 64 µM -0.124135472792658 0.422600510606254 no 1961 0.450604006068724 2645 688802
SGTC_1804 st050076 49.1 µM -0.127992359427466 0.421379961340868 no 1962 0.449077509801173 2727 3895976
SGTC_2872 9044037 25.97 µM -0.12866791693619 0.421166251979835 no 1963 0.448810211458004 2615 6465195
SGTC_602 3130-1533 38.1 µM -0.129779675459943 0.420814603118142 no 1964 0.448370371768831 2739 720941
SGTC_331 k048-0133 24.5 µM -0.13111131731218 0.420393488401685 no 1965 0.44784362426406 2635 6813582
SGTC_3226 9131256 49.47 µM -0.132589433102546 0.419926159874726 no 1966 0.447259044897161 2615 17178073
SGTC_1944 st076371 56.9 µM -0.133124565896567 0.419756997395493 no 1967 0.44704743364119 2638 24208455
SGTC_201 4262-0159 12.803 µM -0.133336272191122 0.419690078356487 no 1968 0.446963721317445 2735 1341029
SGTC_2482 5981709 142.65 µM -0.136503352507802 0.41868926230148 no 1969 0.445711687220467 2719 877755
SGTC_2811 7967822 32.47 µM -0.137481208892805 0.418380359902644 no 1970 0.445325222417095 2752 2232244
SGTC_1354 1498-1681 81 µM -0.139343486159197 0.417792210499871 no 1971 0.444589364030517 2731 5754243
SGTC_2883 9059145 45.46 µM -0.140277934079715 0.417497159830414 no 1972 0.44422019898962 2628 16476510
SGTC_1109 tnp00067 928.257 nM -0.141525086843596 0.417103445413997 no 1973 0.443727571529825 2667 676295
SGTC_2610 ononetin 44.17 µM -0.141638848171685 0.417067536161561 no 1974 0.443682639927732 2734 259632
SGTC_1696 st025591 34.7925 µM -0.142024089251073 0.416945938298059 no 1975 0.443530489042189 2665 2787147
SGTC_2178 5812956 200 µM -0.142582192391375 0.416769792183146 no 1976 0.443310081092348 2606 5403383
SGTC_1837 st055472 66.5 µM -0.142592023434272 0.416766689501286 no 1977 0.443306198741158 2814 676091
SGTC_2902 5787006 60.46 µM -0.144114195887144 0.416286353809845 no 1978 0.442705147522098 2677 591003
SGTC_922 1866-0035 480 µM -0.144828915215863 0.416060860550692 no 1979 0.44242297593546 2673 3156169
SGTC_1751 st044839 27.194 µM -0.145489346332021 0.415852519729051 no 1980 0.442162263325223 2631 5291326
SGTC_2730 imipramine 71.33 µM -0.145681335058908 0.41579195904399 no 1981 0.442086478310682 2675 3696 A tricyclic antidepressant.
SGTC_258 haloperidol 50.781 µM -0.149635423301783 0.414545133115241 no 1982 0.440526129531071 2696 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1477 0139-0234 16 µM -0.150857827761198 0.414159851034619 no 1983 0.440043934120418 2652 620880
SGTC_112 phenothiazine 287.218 µM -0.152222546012926 0.413729811544177 no 1984 0.439505706017095 2669 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1946 st076057 65.1 µM -0.15289109214397 0.413519182161435 no 1985 0.439242080379322 2670 953009
SGTC_1746 st038117 42 µM -0.153121708572179 0.413446530871213 no 1986 0.439151148392292 2781 2898218
SGTC_714 4296-0578 26.1 µM -0.154712145850165 0.412945574872678 no 1987 0.438524127144138 2708 1589775
SGTC_553 k007-0256 45.7 µM -0.157501506445517 0.412067324685577 no 1988 0.437424810370238 2733 6287000
SGTC_3045 9092950 49.47 µM -0.158412638340453 0.411780543443474 no 1989 0.437065827783688 2706 44120432
SGTC_1238 0333-0287 48.8 µM -0.15882682813352 0.411650191647689 no 1990 0.436902655653657 2696 7226
SGTC_1309 pyrazolanthrone 13.4 µM -0.159171073820092 0.41154185973951 no 1991 0.436767046519216 2762 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1259 0671-0132 43 µM -0.159663838496735 0.411386801594944 no 1992 0.436572944047364 2720 X1259
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.160109582999216 0.411246551199056 no 1993 0.436397376210674 2708 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2910 7948405 25.97 µM -0.161360149758862 0.410853129703289 no 1994 0.435904875605232 2785 2971328
SGTC_2447 5741742 33.78 µM -0.161861325901208 0.410695487561201 no 1995 0.435707529303531 2777 1776504
SGTC_2582 agaric acid 100 µM -0.162008827299082 0.4106490945708 no 1996 0.4356494512629 2776 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2058 5236698 133 µM -0.16393662915535 0.410042866378828 no 1997 0.434890515637159 2734 766665
SGTC_2584 androsterone 48.74 µM -0.165982057476508 0.409399883692179 no 1998 0.434085535180819 2783 2754130 A steroid.
SGTC_364 0083-0097 67.7 µM -0.166024287264934 0.409386611271967 no 1999 0.434068918471094 2829 5207356
SGTC_612 0302-0167 22.4 µM -0.166488611630611 0.409240685399429 no 2000 0.433886222351027 2779 235821
SGTC_2307 7538926 6.34 µM -0.166509534206353 0.409234110237909 no 2001 0.433877990348948 2767 96582
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.167456036707916 0.408936687609759 no 2002 0.433505618325045 2674 6312947
SGTC_1832 st054113 55 µM -0.168063235311324 0.408745913166522 no 2003 0.433266765938845 2702 1251267
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.168676418732154 0.408553280305658 no 2004 0.433025584053034 2769 6857784
SGTC_957 1187-1561 14.1 µM -0.169941467667567 0.408155932376428 no 2005 0.432528084465543 2692 1538454
SGTC_1478 0453-0656 35.7 µM -0.170325647883724 0.408035281241151 no 2006 0.432377020931664 2717 5258496
SGTC_2868 9035608 32.47 µM -0.170848340930728 0.407871144393569 no 2007 0.432171508633348 2659 6462614
SGTC_144 4161-2749 112.381 µM -0.172201307788475 0.407446358885897 no 2008 0.431639634886847 2696 797501 YMR168C CEP3
SGTC_270 tamoxifen 5.46 µM -0.173124135262249 0.407156684881311 no 2009 0.431276927097265 2878 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3195 9113082 49.47 µM -0.173162174872386 0.407144745399678 no 2010 0.431261977263513 2707 17018038
SGTC_1279 0874-0590 65.2 µM -0.17439625186424 0.406757452869169 no 2011 0.43077702988246 2776 3523074
SGTC_1620 st003704 16.5 µM -0.175659819920318 0.406360999576863 no 2012 0.430280601720481 2734 2834414
SGTC_2044 5102272 200 µM -0.175926732645374 0.406277266112061 no 2013 0.430175751636487 2820 592666
SGTC_2160 5660466 132.927 µM -0.176350338719215 0.40614438501658 no 2014 0.430009358543352 2678 2859134
SGTC_1245 0418-0076 17.2 µM -0.177513530787149 0.405779558647689 no 2015 0.429552518988855 2899 6790114
SGTC_809 3998-0021 90 µM -0.177771496555005 0.405698660715092 no 2016 0.429451216606767 2786 715485
SGTC_1563 conessine 56.1 µM -0.178802072800059 0.405375512749211 no 2017 0.42904655882721 2828 441082 An anti-amoebic, histamine inhibitor.
SGTC_912 3474-0017 2.18 µM -0.179150930494125 0.405266139367922 no 2018 0.428909596041268 2879 3360550
SGTC_3173 9105693 49.47 µM -0.179469699475844 0.405166205826119 no 2019 0.42878445367575 2866 17096658
SGTC_2706 st078239 82.5 µM -0.180257359139846 0.404919302368251 no 2020 0.428475264875214 2726 15434492
SGTC_2446 5162541 200 µM -0.18245215369056 0.404231511817512 no 2021 0.427613949935478 2705 1549321
SGTC_3076 9116187 49.47 µM -0.182475444803721 0.404224214581818 no 2022 0.427604811521672 2843 27241210
SGTC_235 0330-0087 5 mM -0.183808808278164 0.403806520001992 no 2023 0.42708172293424 2746 46494818 YHR062C RPP1
SGTC_3280 9140961 49.47 µM -0.185132978516013 0.403391813866276 no 2024 0.426562367783322 2720 4901226
SGTC_3207 9114163 49.47 µM -0.185159638045281 0.403383465698372 no 2025 0.426551912906545 2983 849233
SGTC_3064 1327-0027 10 µM -0.185646722042704 0.403230947916503 no 2026 0.426360905754008 2735 16000455 YPR107C YTH1
SGTC_1088 bifonazole 369 nM -0.186741708645479 0.402888134894824 no 2027 0.425931576256783 2711 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2475 5812728 15.03 µM -0.186921484802606 0.402831858585766 no 2028 0.425861096822975 2715 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_628 1636-0253 16 µM -0.187606992237561 0.402617288943911 no 2029 0.425592372281552 2831 4456143
SGTC_765 1319-0117 244 µM -0.188283982627801 0.402405413995538 no 2030 0.42532702040707 2737 3487746 YGL099W LSG1
SGTC_1022 4477-0945 21.3 µM -0.188994498652522 0.402183077496531 no 2031 0.425048564265412 2755 4648966
SGTC_2123 5259487 200 µM -0.192402404305721 0.401117108005975 no 2032 0.423713504611477 2865 2173474
SGTC_1462 k081-0014 26.5 µM -0.19313337145458 0.400888562051244 no 2033 0.423427258996813 2769 3270634
SGTC_237 nikkomycin 200 µM -0.193575862427439 0.400750228230004 no 2034 0.423253999834964 2890 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1041 0206-0046 107 µM -0.195058131812535 0.40028692425919 no 2035 0.422673719460099 2845 50494
SGTC_222 nsc-310342 10.666 µM -0.195207451932537 0.400240259939993 no 2036 0.422615272743 2741 432556
SGTC_2979 9012552 45.46 µM -0.195517584983217 0.400143344212655 no 2037 0.422493886250591 2849 17100905
SGTC_2636 apigenin dimethyl ether 100 µM -0.196276384894226 0.399906247262783 no 2038 0.422196922003867 2898 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1169 aniline yellow 25.8 µM -0.196526603071607 0.399828071407926 no 2039 0.422099006202695 2796 6051 A DNA damaging agent.
SGTC_2071 5230951 39.92 µM -0.19739335660926 0.39955730200392 no 2040 0.421759864003544 2777 1799272
SGTC_168 3970-0862 530.542 µM -0.197821906576914 0.399423443006809 no 2041 0.421592202948277 2835 3135186
SGTC_1857 st056007 79.3 µM -0.198307373129955 0.399271820209412 no 2042 0.42140229166174 2834 619834
SGTC_174 3553-0389 74.3 µM -0.200401941852434 0.398617810848144 no 2043 0.420583120457741 2908 738071
SGTC_2353 9059630 146.67 µM -0.203764050885079 0.397568619720295 no 2044 0.419268943329622 2881 4779114
SGTC_1940 st075990 51.1 µM -0.204832645100648 0.397235305323126 no 2045 0.418851440317002 3023 1084979
SGTC_2799 7812892 81.82 µM -0.205487955338142 0.397030938981766 no 2046 0.418595453782424 2942 20205235
SGTC_2336 9001819 198.65 µM -0.207946854116034 0.396264354470484 no 2047 0.417635232211991 3002 2989602
SGTC_120 rhodamine 6G 52.259 µM -0.20981258086771 0.395682964172993 no 2048 0.416906976750525 2766 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2841 9004761 38.96 µM -0.209876338846505 0.39566310026002 no 2049 0.416882094904761 2791 2991039
SGTC_3008 9078912 71.4286 µM -0.212704164212709 0.39478235946334 no 2050 0.415778859259554 2818 16648731
SGTC_576 1073-0113 22.7 µM -0.214930100369918 0.394089457949392 no 2051 0.41491090828019 2826 5439563
SGTC_2941 9056145 11.23 µM -0.215577950716519 0.393887854428127 no 2052 0.414658372226493 2757 2119517
SGTC_556 4058-0063 51.5 µM -0.215870033166088 0.393796971050583 no 2053 0.414544528217749 2814 6615692
SGTC_2312 7706453 155.7 µM -0.216315053081368 0.393658511295399 no 2054 0.414371088082174 2842 976098
SGTC_1882 5615643 20 µM -0.216517563823621 0.393595508255538 no 2055 0.414292167947376 2753 2253075
SGTC_189 3970-0742 2.116 µM -0.216533181504615 0.393590649560431 no 2056 0.414286081749783 2800 2891807
SGTC_85 0868-0259 160.055 µM -0.217783761301544 0.393201645260963 no 2057 0.413798798749286 2852 83173
SGTC_1425 4048-4433 7.33 µM -0.217835695672246 0.393185492902199 no 2058 0.413778565611447 2847 23734946
SGTC_2199 6590217 200 µM -0.22047709951796 0.39236422024472 no 2059 0.412749802762999 2855 703109
SGTC_757 1066-0008 322 µM -0.220896079835159 0.392233993651104 no 2060 0.41258667493447 2954 6842497
SGTC_959 1222-0044 107 µM -0.22187757288527 0.391928975289614 no 2061 0.412204594824728 2910 6083612
SGTC_1258 0671-0043 57.1 µM -0.221997905049489 0.391891584257768 no 2062 0.412157757086976 2859 4298767
SGTC_2511 berberine 10.47 µM -0.22255670597125 0.391717960122455 no 2063 0.41194026746571 2816 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3258 9138477 49.47 µM -0.224077768054006 0.391245462705774 no 2064 0.411348395587499 2821 4970355
SGTC_170 4197-0004 226 µM -0.227495880050679 0.390184258701464 no 2065 0.410019086252011 2949 218692
SGTC_695 3505-6186 243 µM -0.228837161917122 0.389768060654458 no 2066 0.409497741013854 2937 1819379
SGTC_589 1227-0070 34.1 µM -0.229048324984269 0.389702548526045 no 2067 0.409415678219401 2941 2841384
SGTC_215 1287-0124 461.5 µM -0.229714311250524 0.389495950648437 no 2068 0.409156886748998 2878 5560863
SGTC_395 anisomycin 6.25 µM -0.230012413114073 0.389403485563075 no 2069 0.409041062015229 2863 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_792 4534-1957 155 µM -0.232666019650021 0.388580667739875 no 2070 0.408010378752409 2866 1717904
SGTC_115 0527-0192 112.043 µM -0.234760252609003 0.387931650415923 no 2071 0.407197409722698 2896 4233931
SGTC_1418 3966-3099 2.4 µM -0.236924282136031 0.387261331386573 no 2072 0.406357765901519 2902 740335
SGTC_2956 9076196 2.52 µM -0.237067508268452 0.387216978205644 no 2073 0.406302209282365 2937 16423868
SGTC_2711 st079103 59.1 µM -0.237108727334872 0.387204214071009 no 2074 0.406286220985552 2877 54693780
SGTC_2425 5628681 7.85 µM -0.237988899355838 0.386931684037067 no 2075 0.405944851958224 2913 5714958
SGTC_312 4092-0653 6.84 µM -0.238431510447434 0.386794658225355 no 2076 0.405773215110277 2922 1148278
SGTC_3037 9091026 49.47 µM -0.240808943440622 0.386058882176783 no 2077 0.404851598854415 2915 25236398 YIL048W NEO1
SGTC_441 propafenone 146 µM -0.242004916255471 0.385688903138332 no 2078 0.404388176911917 2809 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_420 mitomycin C 81.9 mM -0.242477082128858 0.385542865320115 no 2079 0.404205256443836 2843 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2842 9000675 19.48 µM -0.242573782522051 0.385512958521672 no 2080 0.404167796595724 2901 2989072
SGTC_622 1348-1566 26.3 µM -0.243239076510943 0.385307219667485 no 2081 0.403910098503585 2929 7340407
SGTC_2989 9073649 71.4286 µM -0.244951712657722 0.384777744075796 no 2082 0.403246910085636 2826 21367202
SGTC_431 k089-0097 107 µM -0.245679625777709 0.384552768727267 no 2083 0.402965122580879 2960 5499420
SGTC_294 k038-0071 157 µM -0.248491294105718 0.383684135056991 no 2084 0.401877152592919 2887 24152826
SGTC_2339 9000433 200 µM -0.250565427268197 0.383043728828 no 2085 0.401075057083625 2900 2988954
SGTC_2167 5876490 200 µM -0.251170333251482 0.382857019074806 no 2086 0.400841210060963 3072 686534
SGTC_685 1278-0033 54.9 µM -0.251543109868824 0.382741971720992 no 2087 0.400697118243197 2993 3590572
SGTC_1933 st074711 15.9 µM -0.252434222017742 0.382466996160366 no 2088 0.40035272554181 2804 17250958
SGTC_3154 9100113 49.47 µM -0.25291044626857 0.382320069210179 no 2089 0.400168708446571 2876 25237525
SGTC_2125 5246583 200 µM -0.254573434091752 0.381807129372563 no 2090 0.399526289902004 2962 835267
SGTC_260 nsc-65238 3.989 µM -0.254789109692865 0.381740620546675 no 2091 0.399442993477766 2975 3246252
SGTC_653 0203-0016 55.2 µM -0.256045837469409 0.381353147412003 no 2092 0.398957721757748 2905 295302
SGTC_674 0498-0004 451 µM -0.256243444474664 0.381292232212035 no 2093 0.398881432154836 2916 4231473
SGTC_662 k832-1615 104 µM -0.256458244508563 0.38122602034966 no 2094 0.398798509267499 2951 5878478
SGTC_2295 7971645 200 µM -0.259645714327516 0.380243896023869 no 2095 0.397568535180738 2930 2978226 YKL099C UTP11
SGTC_2010 4012422 159 µM -0.260097991779005 0.380104602499771 no 2096 0.397394093480269 2947 952393
SGTC_318 1488-0629 67.2 µM -0.260608928462481 0.379947261667426 no 2097 0.397197051821938 2941 3662576
SGTC_16 erodoxin 22.806 µM -0.261609163982404 0.379639300832358 no 2098 0.396811389091523 2954 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2683 piperine 63.03 µM -0.263832038321656 0.378955177354819 no 2099 0.395954672982127 2889 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_456 gingerol 170 µM -0.26621047854877 0.378223595847518 no 2100 0.395038556702913 3057 442793 A herb.
SGTC_2992 9074591 71.4286 µM -0.266214969707788 0.378222214829399 no 2101 0.395036827366668 2986 17741321
SGTC_840 0245-0196 390 µM -0.267138531709116 0.377938255324071 no 2102 0.394681250614973 3019 3827528
SGTC_35 0133-0054 64.071 µM -0.267389175233933 0.377861203527595 no 2103 0.394584766518585 2916 99677
SGTC_2519 cryptotanshinone 88.04 µM -0.268137216734976 0.377631272603113 no 2104 0.394296849778992 3044 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2925 9010536 32.5 µM -0.268341366945007 0.377568529004674 no 2105 0.394218283596952 2936 2994177
SGTC_753 1322-0200 289 µM -0.269064396893091 0.377346338716186 no 2106 0.393940063790913 3030 5403907
SGTC_2152 5568786 200 µM -0.269513439824605 0.377208366274566 no 2107 0.393767300620885 2878 5399883
SGTC_3109 9122853 49.47 µM -0.270718126869382 0.376838292920916 no 2108 0.393303917011587 2927 1234709
SGTC_1226 3909-7979 35.4 µM -0.270951915548188 0.376766487398782 no 2109 0.393214007540648 2988 6615510
SGTC_927 2425-1185 123 µM -0.274820951077981 0.375578778091142 no 2110 0.391726900505259 2857 730375
SGTC_386 1509-0011 3.07 µM -0.275167948186489 0.375472314971817 no 2111 0.391593605209547 2888 3107280
SGTC_864 0469-0573 172 µM -0.275480132075771 0.375376541093229 no 2112 0.391473693921584 2884 689425
SGTC_3031 9088762 49.47 µM -0.275624169486707 0.375332354914161 no 2113 0.391418371956068 2840 205253
SGTC_1501 4491-0275 38.4 µM -0.276427276480357 0.37508601677008 no 2114 0.391109954485367 2978 5104718
SGTC_132 0417-1715 25.805 µM -0.277185658202356 0.374853444035068 no 2115 0.390818775722369 3020 6769098
SGTC_523 1934-0222 13.7 µM -0.277457183223354 0.374770186582431 no 2116 0.39071453924151 2897 1361595
SGTC_514 4466-0038 2.65 nM -0.277852241227499 0.374649060756332 no 2117 0.390562893372838 2938 5722064
SGTC_33 0986-0033 35.816 µM -0.278110407413155 0.374569913003504 no 2118 0.390463803408923 2892 2848082
SGTC_2445 5742597 35.57 µM -0.278330937836846 0.374502307685438 no 2119 0.390379164527284 2887 1774255
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.279174899795378 0.374243620226105 no 2120 0.390055302603014 2936 4330530
SGTC_584 0986-0246 15.4 µM -0.279302125389275 0.37420462851126 no 2121 0.390006487671814 2896 53315 YDR232W HEM1
SGTC_487 nimodipine 119 µM -0.281293856556633 0.373594376766463 no 2122 0.389242510960973 2971 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1722 st034304 3.6505 µM -0.281888382433387 0.373412279750471 no 2123 0.389014548968347 2908 4036148 YLR033W RSC58
SGTC_804 1595-0054 20.9 µM -0.281998939539338 0.373378420388545 no 2124 0.388972161721472 2913 761523 Stimulates phospholipase C.
SGTC_1614 st002383 48.6 µM -0.282138297366979 0.37333574187327 no 2125 0.388918734251205 2949 1947235
SGTC_796 1234-0020 70.7 µM -0.282293185791508 0.373288308915795 no 2126 0.388859355073606 2883 46495034
SGTC_1 0258-0098 57.368 µM -0.284519256703889 0.372606810448606 no 2127 0.388006239421114 2959 6790032 YDR047W HEM12
SGTC_3092 9117248 49.47 µM -0.286698541981091 0.371940021222065 no 2128 0.387171577038497 2929 17141857
SGTC_1295 1013-0063 9.78 µM -0.287149335579373 0.371802141141296 no 2129 0.386998988845949 3027 6826038
SGTC_2350 9023895 38.85 µM -0.288223166805122 0.371473764545899 no 2130 0.386587958169448 3065 2997209
SGTC_1172 0370-0043 85 µM -0.288492986246418 0.371391268702265 no 2131 0.386484699285294 3068 376585
SGTC_672 1441-0018 53.7 µM -0.288747934799331 0.371313324980904 no 2132 0.386387138819212 2903 251141
SGTC_2179 6298986 200 µM -0.289488912472803 0.371086820785162 no 2133 0.3861036317073 3061 738374
SGTC_1839 st053978 48 µM -0.290060541802801 0.370912113985712 no 2134 0.385884960882725 3009 3788398
SGTC_1181 1222-0449 220 µM -0.290174556442928 0.370877270927197 no 2135 0.385841350108614 3094 658318
SGTC_1146 3579-1023 7 µM -0.290526666126913 0.370769672322819 no 2136 0.385706676726852 3032 X1146
SGTC_2073 5212005 126 µM -0.291401084371134 0.370502509018357 no 2137 0.385372292654091 2864 691789
SGTC_2479 5617353 43.85 µM -0.296388593732178 0.368979859509858 no 2138 0.383466667555007 3090 2731746
SGTC_135 0933-0004 26.348 µM -0.29676351887191 0.368865480362402 no 2139 0.383323529560497 3042 21230617 YGL099W LSG1
SGTC_2533 agelasine 13.65 µM -0.297125318232336 0.368755116532522 no 2140 0.383185417792114 3129 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2699 st077704 54.6 µM -0.298824999237676 0.36823678822819 no 2141 0.382536787674227 2989 645852
SGTC_424 splitomicin 100 mM -0.300148132562539 0.367833456382704 no 2142 0.382032083112144 3019 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_741 4582-0002 126 µM -0.301718630463462 0.36735490929963 no 2143 0.38143328236176 2928 2912688
SGTC_2210 7115885 190.385 µM -0.302214351969211 0.367203900515408 no 2144 0.381244332090527 2962 2927039
SGTC_1005 4092-0690 4.4 µM -0.302671878064121 0.367064545204368 no 2145 0.381069965580895 2988 1529343
SGTC_739 1486-1183 203 µM -0.304320703311216 0.36656248415263 no 2146 0.380441786864275 3073 4346692
SGTC_1847 st056231 15 µM -0.305464749375911 0.366214260522842 no 2147 0.380006106847464 2940 5393180
SGTC_2381 9035592 200 µM -0.305486143871267 0.366207749535422 no 2148 0.379997960761964 2999 4749657
SGTC_3113 9123498 49.47 µM -0.307512550573771 0.365591227973933 no 2149 0.379226635779012 2966 8897275
SGTC_3335 9143315 29.6265 µM -0.307765364717801 0.365514335170775 no 2150 0.379130439063919 2964 4899691
SGTC_3140 9094243 49.47 µM -0.308306682324417 0.365349712923384 no 2151 0.378924490892998 2986 19291112
SGTC_2928 9011484 9.79 µM -0.30895484644886 0.36515262979124 no 2152 0.378677937414974 3069 2994751
SGTC_1727 st034309 9.9045 µM -0.311345848425426 0.364425921411065 no 2153 0.377768858026313 3204 870305
SGTC_2394 5221648 200 µM -0.311528308727142 0.364370485369372 no 2154 0.377699512782427 3089 788586
SGTC_948 3448-0295 75.3 µM -0.312679968416177 0.364020647615714 no 2155 0.377261907943445 2934 678569
SGTC_2977 9011197 71.43 µM -0.314362372973701 0.363509790079394 no 2156 0.376622915306495 3162 2704722
SGTC_3343 9148379 18.9835 µM -0.315669586450277 0.363113025722958 no 2157 0.376126656835201 3120 1955036
SGTC_3149 9097855 49.47 µM -0.316730374959382 0.362791163985896 no 2158 0.37572409931347 3107 25236625 YMR079W SEC14
SGTC_2008 4012253 172 µM -0.316859309592116 0.362752049570529 no 2159 0.375675179253678 2927 603940
SGTC_1340 1486-1359 257 µM -0.317015355582976 0.362704712399702 no 2160 0.375615975342524 2971 4309068
SGTC_1263 0774-1208 64.8 µM -0.318593745505392 0.362226019615007 no 2161 0.375017298428325 3147 906585
SGTC_2725 haloperidol 53.21 µM -0.320070308320748 0.361778403827573 no 2162 0.374457516576677 2957 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2308 7584454 197.62 µM -0.320956096897236 0.361509970235951 no 2163 0.374121830852992 3147 893577
SGTC_1045 1348-1485 165 µM -0.321120921858651 0.361460028410773 no 2164 0.374059377952881 2952 6810614
SGTC_340 k038-0059 454 µM -0.321433358185803 0.361365366943903 no 2165 0.373941003532136 2983 23733424
SGTC_2142 5622915 118.518 µM -0.322090733438833 0.361166224143048 no 2166 0.373691979088114 3008 5322196
SGTC_2146 5545642 200 µM -0.323338056451568 0.360788468222068 no 2167 0.373219617833696 3023 825326
SGTC_1907 st060210 83.7 µM -0.325374656248423 0.360171969179385 no 2168 0.372448767126759 3135 688793
SGTC_1473 k844-0725 134 µM -0.325809197505967 0.36004047620665 no 2169 0.372284359758188 3015 54682906
SGTC_2194 5927483 104.545 µM -0.326168505862921 0.359931761352303 no 2170 0.372148434107639 2969 760979
SGTC_1924 st058459 75.1 µM -0.327275394182248 0.359596924711242 no 2171 0.371729800602975 2923 688683
SGTC_3002 9075603 71.4286 µM -0.33488504239491 0.357297915136342 no 2172 0.368855902860417 3006 20105405
SGTC_3166 9102297 49.47 µM -0.335924512986158 0.35698427217892 no 2173 0.368463895718014 3051 25237072
SGTC_3070 9117005 49.47 µM -0.338093568757176 0.356330107105256 no 2174 0.367646338436467 3061 8779016
SGTC_3305 9127027 53.8275 µM -0.339390240268142 0.355939245884066 no 2175 0.367157884950072 3022 41905295
SGTC_2476 5806916 10.51 µM -0.339587738255595 0.355879726497084 no 2176 0.367083506706601 2982 2870194
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.342452258943697 0.355016849942042 no 2177 0.366005283095938 3065 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1647 st011722 22.4 µM -0.344897106660706 0.354280978526189 no 2178 0.365085862927277 3158 2854783
SGTC_1007 4101-0031 70 µM -0.346258076912031 0.353871577327624 no 2179 0.364574385933042 3162 1146276
SGTC_1556 plumbagin 1.48 µM -0.347594472769483 0.353469732842627 no 2180 0.364072378918921 3055 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_951 1171-0579 82.7 µM -0.349525265330232 0.352889446038348 no 2181 0.363347503220269 2971 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_477 mead ethanolamide 10 µM -0.350758924640664 0.352518856965046 no 2182 0.362884607524952 3036 16061185
SGTC_2990 9074105 71.4286 µM -0.350856249985797 0.352489626554788 no 2183 0.362848097461833 3098 6502001
SGTC_1748 st037455 53.6035 µM -0.352113998360164 0.352111956500148 no 2184 0.362376385329858 3192 580690
SGTC_109 0132-0036 33.701 µM -0.353563160194775 0.351676990629182 no 2185 0.361833143553121 2969 67274 A color developer.
SGTC_2027 5150920 200 µM -0.354126774349721 0.351507874253864 no 2186 0.361621938765608 3080 786715
SGTC_188 3229-0966 278.469 µM -0.354877157898391 0.351282762027304 no 2187 0.361340810760914 3154 5722370
SGTC_2119 5528445 120.635 µM -0.356029569166956 0.350937144598099 no 2188 0.360909210579749 3167 791935
SGTC_681 1642-0006 26.6 µM -0.357827947232 0.350398042924598 no 2189 0.360236037318472 3140 4446530
SGTC_1579 chlormadinone acetate 49.4 µM -0.358636647127596 0.350155716229624 no 2190 0.359933463842222 3171 45114258 A steroidal progestin.
SGTC_2219 9098279 200 µM -0.360669750227556 0.349546767089841 no 2191 0.359173170275469 3136 902349
SGTC_336 4111-0029 111 µM -0.361434108349778 0.349317928764876 no 2192 0.358887477042402 3056 3131175
SGTC_47 0149-0135 24.25 µM -0.361826223399087 0.349200556151865 no 2193 0.35874094728022 3035 5239155
SGTC_143 4032-1194 15.74 µM -0.362812675419801 0.34890534321749 no 2194 0.358372411269877 2979 1806963
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.363535939790203 0.348688951854484 no 2195 0.358102285282013 3057 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1160 4092-0570 10.5 µM -0.365491903445916 0.348103999475174 no 2196 0.357372124763357 3040 4994975
SGTC_1754 st042065 16.137 µM -0.366539193056674 0.347790944422016 no 2197 0.356981386270838 3124 1126236 YIL048W NEO1
SGTC_1136 pergolide 1.05886 µM -0.366927519156779 0.347674892618518 no 2198 0.356836541845903 3028 47811 A dopamine receptor agonist.
SGTC_1270 0831-1170 17.3 µM -0.369894712537624 0.346788614557267 no 2199 0.355730470630572 3068 6764716
SGTC_2484 5809818 12.04 µM -0.370071181084759 0.34673593109225 no 2200 0.355664727155184 3083 2870548
SGTC_1305 1181-0477 144 µM -0.371928215225146 0.346181706242928 no 2201 0.35497314849283 3197 6252086
SGTC_3289 9119912 71.43 µM -0.371973793334224 0.34616810776298 no 2202 0.35495618073018 3172 17014829
SGTC_994 3910-0338 138 µM -0.374227585527504 0.345495924155831 no 2203 0.354117501157224 3243 3479481
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.374892029000977 0.345297849653233 no 2204 0.353870383705997 3042 279621
SGTC_645 0845-0943 5.41 µM -0.374901938089006 0.345294896016366 no 2205 0.353866698818808 3109 1885106
SGTC_1361 1608-0041 5.61 µM -0.375889057476324 0.345000709101104 no 2206 0.353499687923922 3063 X1361
SGTC_2963 9082507 9 µM -0.376328353726645 0.344869817648582 no 2207 0.353336401379929 3222 16459611
SGTC_2982 9019404 25.97 µM -0.376369917519779 0.34485743438088 no 2208 0.353320953503256 3058 22333232
SGTC_1600 coumarin 106 71.1 µM -0.37724695915805 0.344596172615795 no 2209 0.352995042740828 3222 100336 A hepatotoxic, DNA x-linker.
SGTC_108 0509-0257 621.132 µM -0.378731378958371 0.344154148005227 no 2210 0.352443674582384 3114 536624
SGTC_151 3013-0144 2.285 µM -0.378733784706158 0.344153431803837 no 2211 0.352442781250336 3248 906558 YHR107C CDC12
SGTC_1167 k781-0610 148 µM -0.379031549142025 0.344064790376841 no 2212 0.352332217960441 3104 4525169
SGTC_1442 4112-3290 3 µM -0.381517254877286 0.343325155918018 no 2213 0.351409735066611 3062 704353
SGTC_209 4077-0173 175.592 µM -0.381770122126014 0.343249947532411 no 2214 0.351315941135419 3148 15993494
SGTC_492 tmb-8 126 µM -0.38193448622969 0.34320106529383 no 2215 0.351254979789733 3109 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1931 st074438 57.1 µM -0.383720947269461 0.342669937299342 no 2216 0.350592642655813 3123 2787313
SGTC_2279 7948423 32.93 µM -0.384675839906401 0.34238616812292 no 2217 0.350238798653811 3247 1247112
SGTC_1294 1000-1494 117 µM -0.385936314473475 0.342011724198628 no 2218 0.349771917566867 3112 712797 YDL207W GLE1
SGTC_2757 clomiphene 4.22 µM -0.386573313042034 0.341822552749002 no 2219 0.349536058967497 3282 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3269 9137823 49.47 µM -0.388776807270557 0.341168480725102 no 2220 0.348720629454848 3058 17682936
SGTC_2289 7946404 165.07 µM -0.392570963204326 0.340043364709922 no 2221 0.347318194629509 3067 1246120 YPR165W RHO1
SGTC_254 nsc-64875 3.808 µM -0.396447725315039 0.338895222301987 no 2222 0.345887382187257 3257 56993
SGTC_3184 9108758 49.47 µM -0.397559936253163 0.338566105264603 no 2223 0.345477298787962 3074 902885
SGTC_1685 st024049 53.0905 µM -0.399250535215991 0.338066072141405 no 2224 0.344854305240406 3156 1941139
SGTC_2493 resveratrol 26.09 µM -0.40074170711779 0.337625261077207 no 2225 0.344305150345625 3054 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.401901267829692 0.337282632742409 no 2226 0.343878344819403 3122 689007
SGTC_2816 7982706 58.44 µM -0.402343819012512 0.337151902760934 no 2227 0.343715505113898 3199 2981853
SGTC_2945 9067681 61.76 µM -0.402892235694785 0.336989927305855 no 2228 0.343513751708674 3176 16456930
SGTC_3288 9119690 36.221 µM -0.40348716148936 0.336814249509034 no 2229 0.343294938777181 3146 17595618 YKL019W RAM2
SGTC_2961 9083290 32.55 µM -0.405175662180462 0.336315840010954 no 2230 0.342674196693641 3192 17741490
SGTC_552 k242-0005 476 µM -0.406486474052058 0.335929114415406 no 2231 0.342192596665412 3244 4088318
SGTC_1863 st057641 20.1 µM -0.406650356906807 0.335880776664218 no 2232 0.342132403163796 3192 3921635
SGTC_191 3914-0123 66.505 µM -0.406986785214236 0.3357815546093 no 2233 0.34200884699501 3080 3144412
SGTC_2664 lyso-paf C-16 73.48 µM -0.407285617556442 0.335693430247941 no 2234 0.341899112451527 3109 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3223 9129970 49.47 µM -0.407307073390564 0.335687103363132 no 2235 0.34189123414553 3072 17248386
SGTC_1756 st041558 35.5 µM -0.40938230559887 0.335075380366826 no 2236 0.341129561428223 3298 3955792
SGTC_2752 diclazuril 33.15 µM -0.411637543949523 0.334411092093714 no 2237 0.340302554529788 3226 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2969 9091408 28.7 µM -0.411766202338284 0.334373210923462 no 2238 0.340255397976254 3089 4286311
SGTC_3340 9146634 11.102 µM -0.412904857941188 0.33403802761791 no 2239 0.339838160863037 3219 4907387
SGTC_826 1683-5028 118 µM -0.413857182679101 0.33375779568885 no 2240 0.339489351481121 3209 722377
SGTC_3252 9135871 49.47 µM -0.414133768131378 0.333676424771241 no 2241 0.339388071865785 3267 17682838
SGTC_2076 5212012 200 µM -0.414528213998642 0.333560393075814 no 2242 0.339243654383351 3155 604802
SGTC_1778 st046819 58.9 µM -0.415412666194489 0.33330027713799 no 2243 0.338919917961356 3136 671715
SGTC_2726 cimetidine 79.27 µM -0.415881367620419 0.33316246530191 no 2244 0.33874840717049 3152 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2540 epiandrosterone 100 µM -0.416293050940903 0.333041437025226 no 2245 0.338597788453223 3151 441302 A steroid.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.416296677849645 0.333040370849626 no 2246 0.338596461624789 3154 5355888
SGTC_508 roscovitine 141 µM -0.416706632023479 0.332919868345419 no 2247 0.33844650140927 3154 160355 A CDKinase inhibitor.
SGTC_1300 1094-0077 113 µM -0.418065021751854 0.332520704723358 no 2248 0.337949789006062 3147 5532636
SGTC_2082 5219693 150 µM -0.420386771915091 0.331838896768167 no 2249 0.337101464982267 3136 2834649
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.420615335315663 0.331771806620137 no 2250 0.337017996881425 3239 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_25 0118-0223 35.662 µM -0.420879296816545 0.33169433279107 no 2251 0.33692161188267 3283 5333628
SGTC_2704 st078022 71.1 µM -0.421299013567724 0.331571158953712 no 2252 0.336768375225652 3302 54697681
SGTC_2239 6685329 187.64 µM -0.42230511358499 0.331275973998967 no 2253 0.336401163089705 3267 805680
SGTC_1368 1852-0141 284 µM -0.4241114572143 0.330746264466157 no 2254 0.335742265107471 3252 2838987
SGTC_486 niguldipine 82 µM -0.424820275026474 0.330538496418505 no 2255 0.335483848163372 3132 1236 A calcium channel blocker.
SGTC_2237 6667747 47.222 µM -0.425319051552882 0.330392326779752 no 2256 0.335302053559151 3089 729940 YDL015C TSC13
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.42652470105158 0.330039110406102 no 2257 0.334862776469076 3159 390807
SGTC_636 0kpi-0074 126 µM -0.427447728144809 0.329768795610213 no 2258 0.334526625150478 3203 616434
SGTC_953 1188-0045 9.7 µM -0.430861986505261 0.328769680125559 no 2259 0.333284362514842 3264 6144426
SGTC_1978 st071761 42 µM -0.431459959641558 0.32859482067045 no 2260 0.333066980250048 3156 5147680
SGTC_1412 3909-8563 178 µM -0.434136463171184 0.327812617179242 no 2261 0.332094674175016 3281 23767530
SGTC_1237 0330-0133 46.1 µM -0.436804069111173 0.327033764964772 no 2262 0.331126723870504 3134 X1237 YHR072W ERG7
SGTC_1504 k297-0033 30 µM -0.438384325473449 0.326572737457783 no 2263 0.330553853529935 3107 4388117
SGTC_2807 7945238 51.95 µM -0.438484466885583 0.326543530892152 no 2264 0.330517563885801 3235 17148797
SGTC_2766 oltipraz 83.91 µM -0.439929213906889 0.326122284159143 no 2265 0.32999418817328 3292 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1001 4048-4355 44.4 µM -0.441336722680297 0.32571210827863 no 2266 0.329484622222103 3143 21824233
SGTC_1851 st056236 18.9 µM -0.449362420157016 0.323377303686915 no 2267 0.326585117974966 3351 5393171
SGTC_122 0236-0016 402.397 µM -0.450028103875695 0.323183955965329 no 2268 0.326345088147053 3240 6808838
SGTC_1995 st072814 61.1 µM -0.452054597821778 0.322595655295294 no 2269 0.3256148252231 3201 5769371
SGTC_1569 carminic acid 40.6 µM -0.452615008817509 0.322433043643523 no 2270 0.325412994668912 3342 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3199 9111318 49.47 µM -0.4535988595115 0.322147646789606 no 2271 0.325058787260992 3257 8548020
SGTC_2754 granisetron 64.02 µM -0.45445425158833 0.321899598586201 no 2272 0.324750956141506 3343 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2685 mycophenolic acid 18.85 µM -0.455606672479507 0.321565542865729 no 2273 0.324336422060286 3222 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_560 2332-1943 155 µM -0.455860904083856 0.321491867393667 no 2274 0.324245002405069 3261 21177716
SGTC_2140 5586273 200 µM -0.45962699941812 0.320401289247776 no 2275 0.322891988019693 3299 854421
SGTC_221 trifluoperazine 10.304 µM -0.460398063905897 0.32017819672435 no 2276 0.322615262061905 3283 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1880 MG-132 525 µM -0.461990278200857 0.319717726195239 no 2277 0.322044146076028 3322 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1362 1611-0397 101 µM -0.462365720528056 0.319609188206171 no 2278 0.321909538718124 3224 27816
SGTC_713 1488-1073 324 µM -0.462765683162515 0.319493578547548 no 2279 0.321766165796941 3293 3312542
SGTC_697 0508-1955 564 µM -0.464901254756653 0.318876586246583 no 2280 0.321001085960601 3365 6243113
SGTC_1770 st043884 66.3 µM -0.465980462942339 0.318564980711032 no 2281 0.320614742517802 3251 670149
SGTC_1021 4476-0760 85.3 µM -0.466924715066809 0.318292446963819 no 2282 0.320276871019612 3219 746768
SGTC_2094 5332512 191.667 µM -0.467904261586777 0.318009830310283 no 2283 0.319926527900899 3347 755774
SGTC_616 4092-0450 108 µM -0.469175450075433 0.317643227715924 no 2284 0.319472115946261 3274 787165
SGTC_1098 clofazimine 15.1 µM -0.473166631357558 0.316493359521864 no 2285 0.318047151129566 3340 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_664 1222-0054 14.9 µM -0.47416393750482 0.316206309608894 no 2286 0.317691503717292 3268 6813991
SGTC_54 0159-0055 9 µM -0.474338141283658 0.316156180714579 no 2287 0.317629398487668 3436 3319099
SGTC_484 loperamide 105 µM -0.474627166745603 0.316073018177388 no 2288 0.317526369605588 3252 3955 An opioid-receptor agonist.
SGTC_2605 digitonin 300 nM -0.478384081278607 0.314992872900191 no 2289 0.316188430799944 3427 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1484 3473-2379 286 µM -0.479664798194962 0.314625016469076 no 2290 0.315732881247263 3395 671917
SGTC_2884 9058502 51.95 µM -0.484058397151283 0.31336445586902 no 2291 0.314172212757394 3340 6471554
SGTC_2368 9071271 200 µM -0.484644460921965 0.313196473492103 no 2292 0.313964284748276 3271 27209959
SGTC_2983 9022671 12.99 µM -0.486094982582904 0.312780879871383 no 2293 0.313449912072304 3399 6405161
SGTC_32 0928-0142 34.1 µM -0.486125526755987 0.312772131117624 no 2294 0.313439084630594 3328 2244242
SGTC_409 arachidonic acid 100 µM -0.487606809749158 0.312347974555168 no 2295 0.312914185588853 3265 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2389 9091542 195.52 µM -0.487932396328965 0.312254778075748 no 2296 0.312798863349974 3286 3626624 YOL127W RPL25
SGTC_298 1391-0729 10 µM -0.490001817620689 0.31166270424984 no 2297 0.312066306320992 3271 3237558
SGTC_3102 9121669 49.47 µM -0.491828898095772 0.311140369911256 no 2298 0.311420152867289 3276 41905072
SGTC_2826 7992541 19.48 µM -0.493554753992077 0.310647323196661 no 2299 0.310810330853893 3353 2985066
SGTC_2782 7736369 71.43 µM -0.494907416024185 0.310261128949239 no 2300 0.310332737793427 3281 2950836 YOL077C BRX1
SGTC_2877 9040724 71.43 µM -0.495634329171836 0.310053676646063 no 2301 0.310076213894065 3398 6463895
SGTC_641 4092-0595 30 µM -0.496559216847632 0.309789812174311 no 2302 0.309749959399692 3358 786260
SGTC_2517 totarol 10 µM -0.497209577731306 0.309604327078729 no 2303 0.309520634031748 3329 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1622 st003707 19.4 µM -0.497623868158809 0.309486195340388 no 2304 0.309374588708481 3374 10140899
SGTC_1453 4237-0541 195 µM -0.498981961568532 0.309099083487697 no 2305 0.30889604593289 3363 739892
SGTC_567 1080-0542 68.4 µM -0.499752963846876 0.308879410738866 no 2306 0.308624516960656 3360 5950415
SGTC_1988 st071872 53.4 µM -0.501439080689756 0.308399243252251 no 2307 0.308031070721484 3387 16414116
SGTC_2108 5365811 200 µM -0.502556812054932 0.308081119429442 no 2308 0.307637949977208 3364 780283
SGTC_837 0091-0265 12.5 µM -0.503902186407103 0.307698396019107 no 2309 0.307165057033562 3260 759367
SGTC_1111 tnp00062 510.699 nM -0.504052036957606 0.307655780441033 no 2310 0.307112405073344 3430 676306
SGTC_2091 4-phenylthiadiazole 200 µM -0.504155237588473 0.307626433011932 no 2311 0.307076146487867 3256 270010
SGTC_3163 9099914 49.47 µM -0.504223804938977 0.307606935018601 no 2312 0.307052057027607 3354 16268368
SGTC_226 1,3-diallylurea 8.28947 mM -0.504765574834295 0.307452895012193 no 2313 0.306861748730113 3326 74537 YKL182W FAS1
SGTC_1617 st002906 78 µM -0.504785842986824 0.307447132880507 no 2314 0.306854630116268 3346 5150859
SGTC_1276 0871-0068 94.2 µM -0.50503338832568 0.307376760846572 no 2315 0.306767692712964 3334 3414906
SGTC_632 0781-2353 4.65 µM -0.506012208886277 0.307098571819216 no 2316 0.306424039473421 3365 6811515 YHR007C ERG11
SGTC_3168 9103419 49.47 µM -0.507352174700005 0.30671792227374 no 2317 0.305953868044811 3337 16649256
SGTC_86 0417-1630 471.922 µM -0.509003421201681 0.30624913254268 no 2318 0.305374913028451 3380 3634867
SGTC_1013 4112-3890 241 µM -0.509136706472052 0.306211306603784 no 2319 0.305328202152722 3225 705171
SGTC_929 2805-0021 398 µM -0.509658516523757 0.306063238435612 no 2320 0.305145360200407 3370 3098024
SGTC_1466 k213-0079 57.5 µM -0.510966109644732 0.305692336649536 no 2321 0.304687393946627 3356 3657981
SGTC_603 3794-0023 45.9 µM -0.511386996273316 0.305572993565055 no 2322 0.304540049321171 3381 3802260
SGTC_1333 1482-0047 286 µM -0.512202589601568 0.305341789553602 no 2323 0.30425461545795 3404 3811116
SGTC_130 0136-0219 337.655 µM -0.512880157596176 0.305149771928881 no 2324 0.304017577086797 3320 234244
SGTC_806 3966-4455 5.86 µM -0.514635879937637 0.304652463133803 no 2325 0.30340374380508 3293 714982
SGTC_704 1310-0270 142 µM -0.515110784677965 0.304518008204295 no 2326 0.303237803449016 3352 5718033
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.516658156191159 0.304080099998033 no 2327 0.302697405412524 3325 688664
SGTC_1868 st057644 42.7 µM -0.518216624349273 0.303639335337013 no 2328 0.302153568540571 3291 688665
SGTC_1508 1080-0625 72.9 µM -0.520049340513306 0.303121373326283 no 2329 0.301514592968093 3377 767111
SGTC_3169 9102970 49.47 µM -0.520942033630172 0.302869223724072 no 2330 0.30120357632356 3418 17027839
SGTC_1448 4255-0083 152 µM -0.521847341147172 0.302613607014696 no 2331 0.300888312470906 3436 5399660
SGTC_938 3126-1755 342 µM -0.522342057029309 0.302473963136678 no 2332 0.300716095757693 3427 1777771
SGTC_1475 4092-1048 11.7 µM -0.522666482831693 0.302382402875178 no 2333 0.3006031832822 3404 2881759
SGTC_2078 5212016 200 µM -0.523114111696001 0.302256092349986 no 2334 0.300447422903801 3362 1899708
SGTC_3273 9137859 49.47 µM -0.525500624564606 0.301583073529419 no 2335 0.299617609620782 3422 2377234
SGTC_2681 menadione 3.18 µM -0.525770978407973 0.301506873759088 no 2336 0.299523670530297 3426 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2317 5986382 200 µM -0.526112636394497 0.301410589167703 no 2337 0.299404974688693 3399 877883
SGTC_2248 tofa 1.1 µM -0.526588135192385 0.301276609172322 no 2338 0.299239816546975 3265 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_846 0335-0850 148 µM -0.529199323290316 0.300541340399827 no 2339 0.298333593038369 3386 6819598
SGTC_2729 fluphenazine 10.66 µM -0.530651171449125 0.300132874040245 no 2340 0.297830264237691 3308 3372 An atypical antipsychotic.
SGTC_2808 7946468 45.46 µM -0.5310172454185 0.300029921579305 no 2341 0.297703414350154 3363 2970879
SGTC_1080 nisoldipine 24.4 µM -0.531558165999505 0.299877825553345 no 2342 0.29751602273746 3293 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.531638559158716 0.299855223587688 no 2343 0.297488176659054 3463 688801
SGTC_3318 9139014 38.6185 µM -0.533664667603261 0.299285852423308 no 2344 0.296786779222134 3395 16643984
SGTC_2270 7924575 90.91 µM -0.534141042777067 0.299152054090012 no 2345 0.296621977831675 3437 1262135
SGTC_2176 5809774 33.9695 µM -0.535257759498869 0.298838511054203 no 2346 0.296235815486059 3391 2870539
SGTC_825 1988-2224 89.6 µM -0.536367251394445 0.298527144511487 no 2347 0.295852380013441 3329 1180859
SGTC_3264 9137442 49.47 µM -0.5368709808873 0.298385827169221 no 2348 0.295678368611611 3506 17015726
SGTC_2763 lisinopril 49.32 µM -0.537578307394367 0.298187443698576 no 2349 0.295434104840003 3462 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_835 0312-0010 67.2 µM -0.538398282196657 0.297957541040621 no 2350 0.295151056030336 3362 1626196
SGTC_2463 5473429 200 µM -0.538693890523825 0.297874678874403 no 2351 0.295049045006965 3362 5399405
SGTC_380 3970-0968 6 µM -0.539064370450564 0.29777084423977 no 2352 0.294921219594402 3332 2891601
SGTC_1156 4092-0367 4.88 µM -0.539879606194303 0.297542415780364 no 2353 0.294640031516559 3369 1357585
SGTC_1984 st072354 53.1 µM -0.542668275056483 0.296761638354211 no 2354 0.293679110565204 3329 5762938
SGTC_918 glabranin 770.725 nM -0.542690896177148 0.296755308681658 no 2355 0.293671321702047 3390 124049 Also referred to as licorice root.
SGTC_2057 5236571 38.335 µM -0.543977712032925 0.296395343318333 no 2356 0.293228405118947 3484 54684039 YBR257W POP4
SGTC_1676 st018489 23.4 µM -0.5441864656163 0.2963369668449 no 2357 0.293156582221205 3378 3696235
SGTC_2680 butyl paraben 22.24 µM -0.545456822521798 0.295981834166493 no 2358 0.292719684432108 3437 7184 An antifungal and steroid mimetic.
SGTC_711 k292-0785 179 µM -0.546024133500197 0.295823303550359 no 2359 0.292524674061672 3423 4146315
SGTC_200 k038-0079 37.545 µM -0.55124270717902 0.294366847109157 no 2360 0.29073365371842 3356 3436683
SGTC_2962 9082311 13.18 µM -0.552034768660566 0.294146079671414 no 2361 0.290462266183634 3336 16459453
SGTC_1064 honokiol 6.76 µM -0.553298027585296 0.293794136075826 no 2362 0.290029675725677 3405 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_665 3914-0008 307 µM -0.553557451951266 0.293721884637826 no 2363 0.289940875824885 3377 1069549
SGTC_1628 st004252 77.7 µM -0.554056937704475 0.29358279764466 no 2364 0.289769939805535 3452 692968
SGTC_1895 st058434 18.3 µM -0.555087681243716 0.29329587284459 no 2365 0.289417344161348 3499 5393175
SGTC_530 4358-1714 28 µM -0.556045729062822 0.293029300720748 no 2366 0.28908979703214 3440 1564641
SGTC_2537 larixol 68.93 µM -0.556266462785855 0.292967898576238 no 2367 0.289014355061057 3470 6708759
SGTC_1643 st009866 20.2 µM -0.556979022893774 0.292769724404731 no 2368 0.288770880787586 3437 3156273 YOR207C RET1
SGTC_583 1488-1091 88.9 µM -0.560027103876585 0.291922708596669 no 2369 0.287730475256214 3490 4303273
SGTC_1348 1493-0373 93.8 µM -0.560995469934374 0.291653853325786 no 2370 0.28740031268827 3408 3010129
SGTC_1492 4158-0558 28.5 µM -0.561537633783238 0.29150337842722 no 2371 0.28721554123988 3450 3967268
SGTC_55 0767-0285 6.563 µM -0.561955573500147 0.291387406043287 no 2372 0.287073144224027 3445 3116166
SGTC_2185 6113692 200 µM -0.563518054966563 0.290954030243549 no 2373 0.286541084601073 3467 874150
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.564983679312029 0.290547793073213 no 2374 0.286042432584802 3570 16725076
SGTC_1908 st060353 56.5 µM -0.565226420773948 0.290480536382518 no 2375 0.285959884040129 3532 4227716
SGTC_2356 9061756 188.97 µM -0.565437527173776 0.290422050784382 no 2376 0.285888102767431 3420 20104043
SGTC_744 1594-0068 283 µM -0.567309996241514 0.289903537371438 no 2377 0.285251793353699 3447 668392
SGTC_952 1185-0122 232 µM -0.567535998561743 0.289840983477765 no 2378 0.285175038064244 3445 678600
SGTC_1573 oleylamine 1.06 µM -0.567946143053676 0.289727478096413 no 2379 0.285035769244942 3481 5356789 An amine of the fatty acid oleic acid.
SGTC_898 1000-0849 28.3 µM -0.569190351543795 0.289383277468169 no 2380 0.284613483860027 3450 6751807
SGTC_2623 humulene 100 µM -0.569294130979813 0.289354576374885 no 2381 0.284578274535762 3434 6187145 An anti-inflammatory.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.572002462673659 0.288606037364741 no 2382 0.283660153127819 3504 5282362
SGTC_3257 9139206 32.98 µM -0.572843234462384 0.288373847346749 no 2383 0.28337542130796 3458 4910041
SGTC_371 0195-0006 7.36 µM -0.573793493520158 0.288111527067773 no 2384 0.283053776097213 3408 3928593
SGTC_1638 st008370 60.6 µM -0.575855520560438 0.287542689350994 no 2385 0.282356421158195 3486 24207134
SGTC_3221 9128209 49.47 µM -0.578110456238411 0.28692124370202 no 2386 0.281594774025209 3451 16460723
SGTC_3100 9120536 49.47 µM -0.580657731326456 0.286219997580901 no 2387 0.280735577399066 3414 16421196
SGTC_149 3970-0822 46.1 µM -0.583139125724221 0.285537671549215 no 2388 0.279899823371104 3527 3114250 YBL034C STU1
SGTC_2423 st077119 87.2 µM -0.583743590623282 0.28537157504527 no 2389 0.27969641754031 3457 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1496 4469-0713 57.4 µM -0.585052783710575 0.285011989265598 no 2390 0.279256112807527 3505 746691
SGTC_1450 4112-4260 37.6 µM -0.585583909559367 0.284866170732576 no 2391 0.279077581911692 3517 1633175
SGTC_1949 st076024 69.1 µM -0.587323384645319 0.28438885394916 no 2392 0.278493269310322 3434 2921930
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.587809992548393 0.284255395832658 no 2393 0.278329918054622 3452 5379071
SGTC_1911 st060208 74.3 µM -0.588506391474421 0.284064452085467 no 2394 0.278096222530323 3477 688783
SGTC_2226 7298446 200 µM -0.588988774550667 0.28393222474749 no 2395 0.277934401954531 3502 3283010
SGTC_1217 1183-1422 255 µM -0.591834704417477 0.2831527192771 no 2396 0.276980640710777 3517 2849664
SGTC_2607 solasodine 47.35 µM -0.595225499329583 0.282225316914233 no 2397 0.275846373802079 3471 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1886 st057356 49.9 µM -0.596366936886512 0.281913456238639 no 2398 0.275465061539279 3409 24207747
SGTC_2904 7225135 42.03 µM -0.596839956458566 0.281784267704473 no 2399 0.275307119142266 3568 4446116
SGTC_1188 1403-0014 4.57 µM -0.598068594833545 0.281448842045085 no 2400 0.274897082124208 3500 9614867
SGTC_3313 9133968 57.047 µM -0.598823612548933 0.281242813288064 no 2401 0.274645257276997 3495 1494643
SGTC_1583 clindamycin 39.6 µM -0.599193119915051 0.281142008898622 no 2402 0.274522055111591 3449 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_941 3237-0776 460 µM -0.599947922459277 0.28093614733546 no 2403 0.274270471539014 3544 760008
SGTC_721 1187-1332 279 µM -0.600246577347011 0.280854713621511 no 2404 0.274170958190122 3460 25730
SGTC_2528 xanthyletin 44.79 µM -0.600266209288985 0.280849361013454 no 2405 0.274164417350563 3492 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1507 4075-3230 155 µM -0.601465305715601 0.280522523407572 no 2406 0.273765056588651 3468 659771
SGTC_1879 gemcitabine 100 µM -0.601976517185331 0.280383238534241 no 2407 0.273594884404588 3504 60750 A nucleoside analog which inhibits DNA replication.
SGTC_931 2812-0076 566 µM -0.602554656310157 0.280225758886272 no 2408 0.273402496421267 3499 3450959
SGTC_2251 lansoprazole 556 µM -0.602762037591178 0.280169280623735 no 2409 0.273333502254573 3380 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1093 fluphenazine 7.97 µM -0.602884558592112 0.280135915820101 no 2410 0.273292744506697 3535 6602611 An atypical antipsychotic.
SGTC_1293 1000-1278 195 µM -0.605626358229955 0.279389775614706 no 2411 0.272381447629865 3571 678847
SGTC_3029 9088683 49.47 µM -0.607873943401618 0.278778849489236 no 2412 0.271635541230099 3535 25236615
SGTC_3005 9076496 71.4286 µM -0.608028453252958 0.278736875376476 no 2413 0.271584301408599 3546 21368410
SGTC_1854 st056233 32.9 µM -0.60954696255979 0.278324521237551 no 2414 0.271080977164394 3499 5393174
SGTC_762 1165-0429 115 µM -0.609973105081407 0.278208854866694 no 2415 0.270939811847938 3528 5967793
SGTC_3083 9117465 49.47 µM -0.611066629697102 0.277912150604787 no 2416 0.270577735341918 3536 16420915
SGTC_476 mead acid 10 µM -0.611126540523922 0.277895899560897 no 2417 0.270557905277609 3550 5312531 An omega 9 fatty acid.
SGTC_2049 5262831 67.185 µM -0.611846426473133 0.277700663989255 no 2418 0.270319684855325 3525 763417
SGTC_781 4335-2806 94.4 µM -0.612069470941468 0.27764018715099 no 2419 0.270245897575167 3586 845254
SGTC_673 1082-0474 110 µM -0.612695691432345 0.277470426550209 no 2420 0.270038785975949 3540 3098046
SGTC_2495 cafestol 54.53 µM -0.613259852690861 0.277317532892058 no 2421 0.269852267422958 3568 16667697 An anti-infammatory.
SGTC_1835 st008666 49.2 µM -0.615172080696482 0.276799605608828 no 2422 0.269220541849049 3472 690455
SGTC_2272 7805186 180 µM -0.617924567464885 0.276054926959911 no 2423 0.268312531828288 3536 2956062 YPR165W RHO1
SGTC_1674 st016616 23.6 µM -0.618695068905591 0.275846646017049 no 2424 0.268058629550347 3527 625830
SGTC_2731 amoxapine 43.43 µM -0.620938089943667 0.275240755406596 no 2425 0.267320179136317 3586 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1672 st016598 6.51 µM -0.624072232667904 0.274395251471572 no 2426 0.266290074318759 3488 4665860 YNL267W PIK1
SGTC_856 0433-0016 11.3 µM -0.624202005180386 0.274360270141469 no 2427 0.266247465088253 3544 3911780
SGTC_2215 7188065 200 µM -0.624298302252611 0.27433431383575 no 2428 0.266215849343283 3570 940217
SGTC_198 3454-2873 16.191 µM -0.624542046841567 0.274268619343195 no 2429 0.266135832904482 3508 710957
SGTC_3099 9120367 49.47 µM -0.62470024183997 0.274225986491918 no 2430 0.266083907190582 3581 24824940
SGTC_1976 st070609 63.5 µM -0.625684572953322 0.273960787177893 no 2431 0.26576092699517 3527 682556
SGTC_754 3474-0146 171 µM -0.626526636373203 0.273734018397531 no 2432 0.265484785701954 3481 24762078
SGTC_2970 9090938 41.86 µM -0.626680891655178 0.273692487312307 no 2433 0.265434215918509 3586 17217104
SGTC_450 aminopyrene 156 nM -0.628064026633911 0.273320236832154 no 2434 0.264980998826443 3542 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1185 1319-0113 81.3 µM -0.628309766804762 0.273254125714606 no 2435 0.264900517367166 3564 4672763
SGTC_836 0330-0104 1.35 µM -0.633204668623265 0.271938910234599 no 2436 0.263299998689784 3569 46494820
SGTC_1177 0983-0204 23.6 µM -0.636154568964511 0.271147822378163 no 2437 0.262337840565854 3604 766818
SGTC_3279 9140807 49.47 µM -0.636691128769097 0.271004054198567 no 2438 0.262163026580813 3598 45595718
SGTC_470 aa-861 153 µM -0.637970562432312 0.270661390671784 no 2439 0.261746421413908 3537 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2634 4'-methoxyflavone 100 µM -0.640699882370522 0.269931136103341 no 2440 0.260858845308502 3538 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_982 1491-0518 27.5 µM -0.642317480034464 0.269498798938803 no 2441 0.260333533444592 3537 3091256
SGTC_3348 9149464 3.537 µM -0.645958392997072 0.268526959392086 no 2442 0.259153150674749 3599 1951442
SGTC_1455 4262-0120 131 µM -0.648088225996934 0.267959278056848 no 2443 0.258463944387457 3665 1529587
SGTC_2796 7949634 45.45 µM -0.648213464000536 0.267925916197372 no 2444 0.258423447396935 3578 2971588
SGTC_8 0354-0001 70 µM -0.648535978683092 0.267840011894571 no 2445 0.258319174107337 3629 4993152
SGTC_459 nigericin 15.3 µM -0.648720151951435 0.267790962131766 no 2446 0.25825963822039 3655 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_855 0428-0020 25 µM -0.649017773083103 0.267711708046177 no 2447 0.2581634441895 3571 6812414
SGTC_475 α-linolenic acid 10 µM -0.649496324357572 0.267584298523595 no 2448 0.258008810741373 3691 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3300 9124615 50.48 µM -0.650205279811554 0.267395602382702 no 2449 0.257779815524251 3626 24824903
SGTC_466 geldanamycin 89.2 µM -0.651294016739896 0.267105954051401 no 2450 0.25742835499665 3501 5288382 HSP90 inhibitor.
SGTC_1452 4194-0072 190 µM -0.652633281061841 0.266749872640939 no 2451 0.256996362226305 3646 1343545
SGTC_1396 3511-0007 98.6 µM -0.65443179357789 0.266272064793942 no 2452 0.256416828289556 3555 X1396
SGTC_1085 doxorubicin 7.67 µM -0.656207521288692 0.265800735513999 no 2453 0.255845305098932 3624 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2319 6033012 152.6 µM -0.65698818012178 0.265593660076927 no 2454 0.255594258316855 3560 847246
SGTC_2653 dihydrofissinolide 100 µM -0.65714319093928 0.265552552067952 no 2455 0.255544424753823 3629 6857746
SGTC_2048 5246248 200 µM -0.6578169716085 0.265373906682583 no 2456 0.255327873757447 3606 677046
SGTC_171 k064-0041 9.68 µM -0.659123058204819 0.265027786271231 no 2457 0.254908374959513 3558 53325
SGTC_2121 5257820 149.641 µM -0.65968762506002 0.264878243856654 no 2458 0.254727154813923 3635 791256
SGTC_1211 1056-0033 32.3 µM -0.660934981488227 0.264547996331498 no 2459 0.254327005542918 3617 6741922
SGTC_2603 homopterocarpin 100 µM -0.661056575082874 0.264515814670786 no 2460 0.254288016211725 3622 101795 A weak amylase inhibitor.
SGTC_1054 3429-0080 167 µM -0.661267706884715 0.264459940045426 no 2461 0.254220323645506 3632 1162877
SGTC_1974 st069448 26.9 µM -0.662769173066077 0.264062760338035 no 2462 0.253739199868078 3577 6323587 YNR016C ACC1
SGTC_1776 st049249 45.9 µM -0.663201645544926 0.263948415702855 no 2463 0.253600708870015 3612 1822314
SGTC_1726 st035556 14.5795 µM -0.664364154602842 0.263641176377865 no 2464 0.253228634596152 3662 5919439
SGTC_2618 avocadyne 43.43 µM -0.665377230941191 0.263373579458375 no 2465 0.252904622197022 3576 3015189
SGTC_2420 aureobasidin a 50 nM -0.665870074377636 0.263243448525079 no 2466 0.252747074919473 3677 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_27 0485-0001 32.618 µM -0.666145016975009 0.263170866646919 no 2467 0.252659206472197 3561 2054479
SGTC_1339 1486-1321 22.7 µM -0.66656023381197 0.263061273265593 no 2468 0.252526538516273 3630 3469382
SGTC_1243 0416-0003 5.65 µM -0.667800025581284 0.262734178340072 no 2469 0.252130625122377 3608 2141977
SGTC_3290 9121031 71.43 µM -0.667807519477399 0.262732201854223 no 2470 0.252128233027821 3592 17014854
SGTC_1209 2323-2347 50.3 µM -0.669664590776741 0.262242641143148 no 2471 0.251535814482581 3598 5412760
SGTC_1728 st035614 33.7865 µM -0.670641840306124 0.261985206638943 no 2472 0.251224360748235 3617 15945546
SGTC_2691 st077356 60.2 µM -0.672107035997913 0.26159947653863 no 2473 0.250757778791066 3671 2839272
SGTC_435 c-PAF 6.7 µM -0.672256742233946 0.261560081020492 no 2474 0.250710131672013 3595 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2677 mitomycin C 100 µM -0.672275218254068 0.261555219227168 no 2475 0.250704251627252 3638 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1608 st001473 40.5 µM -0.674051124031073 0.261088122715306 no 2476 0.250139405735433 3592 7292267
SGTC_2334 9017922 200 µM -0.674882320825827 0.260869649781056 no 2477 0.249875266768412 3646 3163164
SGTC_3185 9108267 49.47 µM -0.675285368641734 0.260763745990015 no 2478 0.249747238950313 3610 4910486
SGTC_850 0388-0143 75.9 µM -0.675802773817798 0.260627826391499 no 2479 0.249582936680774 3608 67273
SGTC_594 1487-1584 10.8 µM -0.677600484244969 0.260155861014174 no 2480 0.249012519496271 3620 5013332
SGTC_2762 leflunomide 42.06 µM -0.677938820790957 0.260067084459272 no 2481 0.248905242234816 3635 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2930 9013230 14.89 µM -0.679554452575085 0.259643372265797 no 2482 0.248393308974039 3625 2995857
SGTC_1134 3477-0009 42.5 µM -0.680843962183382 0.259305444092794 no 2483 0.247985114699084 3688 3973534
SGTC_794 k038-0031 316 µM -0.680957152224755 0.259275792427049 no 2484 0.247949301487275 3679 6624242
SGTC_2054 5233173 129 µM -0.681327158869595 0.25917887639783 no 2485 0.247832251028874 3645 6889
SGTC_2746 daunorubicin 9.88 µM -0.681594915205878 0.25910875452489 no 2486 0.247747565539705 3538 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_280 3448-3607 3.04 µM -0.68164176597432 0.259096485931463 no 2487 0.247732749251998 3633 626179
SGTC_2848 9016370 25.97 µM -0.682377155810631 0.258903952171336 no 2488 0.247500248432321 3660 7894410
SGTC_224 benfluorex 43.875 µM -0.683533447628304 0.258601371045769 no 2489 0.247134911174934 3642 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2923 7992654 58.14 µM -0.68547731307678 0.258093108790702 no 2490 0.246521385971846 3668 2985126
SGTC_3214 9129694 49.47 µM -0.685583355152201 0.258065396890285 no 2491 0.246487940329637 3619 17158655
SGTC_2572 astragaloside iv 100 µM -0.688965378619592 0.257182385172339 no 2492 0.245422527479243 3661 45006101 An anti-inflammatory agent.
SGTC_472 calcifediol 10 µM -0.690258396561241 0.256845206996342 no 2493 0.245015852858867 3666 5283731 A vitamin D metabolite.
SGTC_155 k072-0202 43.6 µM -0.690626967598337 0.256749137482019 no 2494 0.244899997862027 3602 5857737
SGTC_512 prima-1 270 µM -0.691426196914179 0.25654087944545 no 2495 0.244648872945097 3663 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2917 7979103 53.79 µM -0.691469183470302 0.256529680779139 no 2496 0.244635370119985 3667 2980565
SGTC_635 k038-0028 24.7 µM -0.692006234194104 0.256389792181455 no 2497 0.244466706978621 3687 4035102
SGTC_400 oxethazaine 37.5 µM -0.692006292056265 0.256389777111917 no 2498 0.244466688810131 3645 4621 A local anesthetic.
SGTC_824 1304-0008 100 µM -0.692265740823987 0.256322211289974 no 2499 0.244385230236751 3678 768245
SGTC_1649 st011737 51.3 µM -0.693710138466761 0.255946230007662 no 2500 0.24393200331241 3656 1761035
SGTC_3046 9092212 49.47 µM -0.693842053329059 0.25591190649734 no 2501 0.243890633329693 3678 25236637
SGTC_1607 st000305 50.6 µM -0.69808744617016 0.254808562854828 no 2502 0.242561254256875 3673 5457690
SGTC_3286 9117135 37.221 µM -0.700515336042311 0.254178694805345 no 2503 0.241802765544469 3650 3438150
SGTC_291 SEC14.278 35.5 µM -0.700664715182903 0.254139968020886 no 2504 0.241756140589317 3663 1068044
SGTC_2862 9027634 71.43 µM -0.700957911158746 0.254063965487653 no 2505 0.241664641002043 3607 5012562
SGTC_2412 st077135 33.4 µM -0.701222235104283 0.253995457410486 no 2506 0.241582167814805 3726 13258915
SGTC_627 1391-0720 175 µM -0.701518887537004 0.253918581908085 no 2507 0.241489625839738 3654 997839
SGTC_2760 etidronate 98.04 µM -0.701880170460892 0.253824974338338 no 2508 0.241376948118038 3676 3305 A chelator and antioxidant.
SGTC_892 0929-0076 29 µM -0.702044432743807 0.253782420352222 no 2509 0.241325727079008 3683 5751038
SGTC_1225 1216-0074 20.6 µM -0.702528316788672 0.253657086536739 no 2510 0.241174874405705 3682 4241466
SGTC_1275 0867-0008 21.1 µM -0.703552191351514 0.253391993625988 no 2511 0.240855846701467 3670 3422836
SGTC_1966 st070145 16.1 µM -0.703723395149758 0.253347681205885 no 2512 0.240802523952841 3633 3748532
SGTC_1310 1188-0297 994 nM -0.705754202194827 0.252822361386751 no 2513 0.240170503632985 3636 1588352
SGTC_820 1582-0060 59.9 µM -0.706346150734438 0.252669346868016 no 2514 0.239986449900675 3684 3848840
SGTC_2522 biochanin a 4.94 µM -0.707713467872474 0.252316091572867 no 2515 0.23956160606426 3643 5280373 A possible chelator.
SGTC_723 4182-0001 115 µM -0.708963200102716 0.251993442999793 no 2516 0.239173656854562 3661 744821 YLR208W SEC13
SGTC_207 4185-0010 4.486 µM -0.709215024951847 0.25192845469485 no 2517 0.239095525489038 3738 3761753
SGTC_1511 0906-3109 28.5 µM -0.709290506065607 0.251908977047124 no 2518 0.239072109380137 3740 2882180
SGTC_410 α-linolenic acid 100 µM -0.711561659934795 0.251323285370927 no 2519 0.238368127903379 3754 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1546 5-methoxyflavanone 78.7 µM -0.711704203100408 0.2512865499551 no 2520 0.23832398219918 3714 147795
SGTC_3159 9100096 49.47 µM -0.711832380734554 0.251253519166949 no 2521 0.23828428933276 3663 25236875
SGTC_2735 sertaconazole 140 nM -0.712876180787221 0.250984622177261 no 2522 0.237961189820443 3754 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2382 9035899 200 µM -0.714104851077192 0.250668295355555 no 2523 0.237581173243128 3729 6462679
SGTC_3275 9138069 49.47 µM -0.714805051663384 0.250488119993405 no 2524 0.237364756619344 3766 17617007
SGTC_1117 retinoic acid 1.10837 µM -0.715463145004933 0.250318842233213 no 2525 0.237161453137646 3703 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_231 b-estradiol 524 µM -0.715647579619843 0.250271412006001 no 2526 0.237104493281716 3653 450 A steroid.
SGTC_1248 0469-0687 58.6 µM -0.716036324668416 0.250171455785115 no 2527 0.236984459845378 3703 4017482
SGTC_320 4092-0846 5.34 µM -0.716421185792012 0.250072519081152 no 2528 0.236865658563135 3689 1359356
SGTC_2191 5911152 200 µM -0.716987978839079 0.249926850727311 no 2529 0.236690757060764 3705 2875902
SGTC_2154 5570129 200 µM -0.717784310289121 0.249722266084183 no 2530 0.236445144458411 3717 673366
SGTC_1221 2958-7315 257 µM -0.717921659134258 0.249686988936796 no 2531 0.236402796127146 3710 4562705
SGTC_159 3970-0959 50 µM -0.718875503081732 0.249442073424151 no 2532 0.236108815677072 3790 6615653
SGTC_1140 3229-1848 2.98 µM -0.719743662816497 0.249219269812713 no 2533 0.235841418786149 3726 2849525
SGTC_2958 9077254 16.72 µM -0.725274575628729 0.247802310460482 no 2534 0.234141799951033 3726 16457351
SGTC_1408 3909-7976 48.8 µM -0.726391643004745 0.247516652977206 no 2535 0.233799356442031 3764 24152374
SGTC_275 trichlorophene 5.69 µM -0.726876799409518 0.247392643163675 no 2536 0.233650715421702 3774 62616
SGTC_5 0352-0601 109.883 µM -0.728116799789238 0.247075840222426 no 2537 0.233271045364609 3635 762456
SGTC_1163 k060-0048 49.9 µM -0.72853263263353 0.246969649296208 no 2538 0.233143800107795 3734 6809982
SGTC_1486 3970-0793 4.53 µM -0.729639566137668 0.246687091579279 no 2539 0.232805265259882 3767 2844330
SGTC_1458 k015-0034 6.33 µM -0.730711654887929 0.246413593509811 no 2540 0.232477647566059 3748 3598957
SGTC_344 k064-0035 6.43 µM -0.732196997340224 0.246034939944701 no 2541 0.23202416839431 3714 5088750
SGTC_2015 5119600 184 µM -0.733325895452199 0.245747362498599 no 2542 0.231679842323954 3722 2828786
SGTC_285 1486-1325 46 µM -0.733427527574286 0.245721481414962 no 2543 0.2316488574108 3722 22310230
SGTC_1953 st076800 12.1 µM -0.734991460833619 0.245323403276648 no 2544 0.231172347331208 3759 297591
SGTC_891 0929-0073 133 µM -0.735997838572951 0.245067426801677 no 2545 0.23086600658744 3770 5603632
SGTC_3121 9125696 49.47 µM -0.736407582787344 0.2449632477807 no 2546 0.230741345675638 3791 1235365
SGTC_142 0335-0849 62.6745 µM -0.73695548620665 0.244823978500835 no 2547 0.230574709866288 3742 3889043 YPR107C YTH1
SGTC_1213 1315-0166 115 µM -0.739332100064252 0.244220370637208 no 2548 0.229852680916537 3779 768401
SGTC_811 0416-0114 265 µM -0.739902594865984 0.244075596958799 no 2549 0.229679549903652 3764 6612453
SGTC_1523 st012844 44.7 µM -0.74298412995121 0.243294400938451 no 2550 0.228745644348053 3849 4274103
SGTC_1481 3346-2004 36 µM -0.743425678592269 0.243182575303754 no 2551 0.228612001238608 3755 2770522
SGTC_1578 josamycin 24.2 µM -0.74444529508822 0.242924455687362 no 2552 0.228303562484883 3722 5282165 A P450 substrate.
SGTC_1175 0741-0056 27.6 µM -0.744760572186449 0.242844672159014 no 2553 0.228208237053645 3800 765927
SGTC_471 1-acyl-paf 4 µM -0.746530417305272 0.242397061262473 no 2554 0.227673532089883 3700 16759367
SGTC_2804 7954240 19.48 µM -0.748183560635525 0.241979369465074 no 2555 0.227174722726586 3768 828705
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.751300486375058 0.241192893885375 no 2556 0.226235918286239 3825 4213774
SGTC_687 k029-0044 34.9 µM -0.753337063753564 0.240679767723634 no 2557 0.225623695929624 3775 5829338
SGTC_2452 5863136 48.41 µM -0.753429593060829 0.240656468607515 no 2558 0.225595902665976 3732 2184096
SGTC_997 3996-0078 137 µM -0.753788343168712 0.240566146022058 no 2559 0.22548816230218 3812 735687
SGTC_1985 st071382 65.5 µM -0.758003129166406 0.239506371986256 no 2560 0.224224554725391 3790 6123237
SGTC_1557 sumaresinolic acid 42.3 µM -0.759357156317314 0.239166454531236 no 2561 0.223819467603189 3718 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2612 dictamnine 15.46 µM -0.760094915261322 0.238981357191212 no 2562 0.223598925908276 3749 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1301 naphtanilide LB 4.81 µM -0.761711570943889 0.238576026263872 no 2563 0.223116083922167 3809 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.762859396291046 0.238288469929956 no 2564 0.222773626856813 3761 688803
SGTC_3128 9127691 49.47 µM -0.763912328713481 0.238024853472754 no 2565 0.222459744958907 3797 41316314
SGTC_895 0964-0006 13.7 µM -0.765631519671595 0.237594773612377 no 2566 0.221947792148502 3744 6738897
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.765758286249637 0.237563078055451 no 2567 0.221910069353585 3801 2374 Ca(2+)-ATPase inhibitor.
SGTC_984 1492-0255 2.91 µM -0.767053281503251 0.237239422244273 no 2568 0.22152491859663 3751 1585198
SGTC_967 1306-0166 352 µM -0.767156327667872 0.237213678510709 no 2569 0.221494287563059 3734 4437607
SGTC_807 1315-0151 48 µM -0.768662459195601 0.236837581083985 no 2570 0.221046858167442 3776 4011080
SGTC_1101 ebselen 5.29 µM -0.768966794283675 0.236761625140748 no 2571 0.220956511615061 3809 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_682 0kpi-0099 17 µM -0.770116801075086 0.236474727471108 no 2572 0.220615305314256 3813 1714895 YML126C ERG13
SGTC_1788 fluconazole 20 µM -0.771029419524666 0.23624718843911 no 2573 0.220344746939456 3832 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2227 7312221 64.1025 µM -0.771214999103187 0.236200933478086 no 2574 0.220289752585746 3807 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1740 st038286 13.222 µM -0.771897274505578 0.236030921973157 no 2575 0.220087635853079 3816 716786
SGTC_3000 9075062 71.4286 µM -0.772640578510963 0.23584577994113 no 2576 0.219867561175907 3772 17057871
SGTC_2874 9043904 71.43 µM -0.772647998855247 0.235843932086761 no 2577 0.219865364824957 3782 4463428
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.775119176291985 0.235228990209563 no 2578 0.219134620621052 3845 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_779 1360-0071 233 µM -0.776123791624765 0.234979249355779 no 2579 0.218837948636123 3873 7566
SGTC_1157 4092-0394 27.6 µM -0.777947530473352 0.234526254318444 no 2580 0.218299973045856 3894 3659885
SGTC_3041 9091929 49.47 µM -0.780885630107389 0.233797482422785 no 2581 0.217434882229735 3824 25236887
SGTC_82 0054-0107 293.755 µM -0.78175732196395 0.233581507963589 no 2582 0.217178603454958 3791 3104697
SGTC_2516 gossypol 71.55 µM -0.782077562660329 0.233502191425073 no 2583 0.217084496033518 3840 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_720 r052-1644 49.9 µM -0.783342704072251 0.233188990002369 no 2584 0.216712946181055 3802 1422863 YOR257W CDC31
SGTC_229 benomyl 22.8748 µM -0.783660446637907 0.23311036555003 no 2585 0.216619688575245 3822 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_342 k048-0088 23.3 µM -0.784671716670396 0.232860227782418 no 2586 0.216323034863038 3804 6820570
SGTC_1928 4'-methoxychalcone 40.3 µM -0.786874661456233 0.232315845701098 no 2587 0.215677620895906 3870 641818
SGTC_2296 7971656 126.45 µM -0.787476690256067 0.232167198257319 no 2588 0.215501434240852 3882 666570
SGTC_2948 9070189 9.45 µM -0.789168720044502 0.23174970133379 no 2589 0.215006700745982 3718 6473636 YDL196W YDL196W
SGTC_1862 st057513 3.81 µM -0.789841726599065 0.231583757859665 no 2590 0.214810103484195 3803 5393163
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.791319808392693 0.231219539251437 no 2591 0.214378696079381 3845 368090
SGTC_1142 3253-1408 9.78 µM -0.791879834943366 0.231081624940082 no 2592 0.214215372967917 3766 256655
SGTC_3104 9120930 49.47 µM -0.793562007751398 0.23066764272391 no 2593 0.213725228701867 3850 17014836
SGTC_2393 9031399 185.94 µM -0.796503281092491 0.229944792884721 no 2594 0.212869784595181 3851 1526623 YDL150W RPC53
SGTC_1192 1488-0095 21.4 µM -0.797886269261327 0.229605347267895 no 2595 0.212468246078846 3877 915875
SGTC_538 2922-0838 53.3 µM -0.799151226309424 0.229295117591032 no 2596 0.212101364620585 3822 777039
SGTC_2437 5741531 144.16 µM -0.799544753855028 0.229198653232208 no 2597 0.211987303559701 3859 2262990
SGTC_646 4092-0839 27.3 µM -0.799697367675659 0.229161249538085 no 2598 0.211943079223583 3868 877796
SGTC_497 capsazepine 133 µM -0.801262655449031 0.228777815217476 no 2599 0.211489802742652 3824 2733484 A calcium channel blocker.
SGTC_1792 st045773 43.6 µM -0.801535696650965 0.228710967706911 no 2600 0.211410793578108 3745 2919270
SGTC_2870 9038528 12.99 µM -0.801598449045034 0.228695605856505 no 2601 0.211392637537696 3858 6463316
SGTC_737 1950-0117 57.9 µM -0.802561282038448 0.228459976006055 no 2602 0.211114177273522 3770 5393513
SGTC_1999 st074831 12.5 µM -0.802880240633328 0.22838194877009 no 2603 0.211021978903407 3820 17112523
SGTC_2429 5902844 64.44 µM -0.80591026504886 0.227641457436897 no 2604 0.210147295998065 3893 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1670 st016595 4.04 µM -0.806259470920963 0.227556203849963 no 2605 0.210046627119847 3840 597879
SGTC_764 1951-2361 146 µM -0.808895523504942 0.226913229976612 no 2606 0.209287622015164 3818 5438930
SGTC_1133 3473-0247 50 µM -0.809104598994464 0.226862277137403 no 2607 0.209227491569467 3859 711311
SGTC_648 0375-0473 33.3 µM -0.809479632261873 0.226770895654679 no 2608 0.209119656887085 3833 1713139
SGTC_2939 9044578 71.43 µM -0.811093127029655 0.226377984719527 no 2609 0.208656096255129 3811 2653634
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.811225219574873 0.226345835177227 no 2610 0.208618172615999 3816 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_894 0960-0238 55.9 µM -0.811684125437179 0.22623416373027 no 2611 0.208486452779393 3796 6741907 YDL195W SEC31
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.812019650966801 0.226152535704728 no 2612 0.208390177867092 3833 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3302 9125395 16.351 µM -0.812324059839646 0.226078492268945 no 2613 0.208302854186769 3802 17599668
SGTC_625 k213-0058 121 µM -0.812579861861465 0.226016282403483 no 2614 0.208229490714075 3903 3655420
SGTC_3325 9138760 55.175 µM -0.816224202962809 0.225131047204962 no 2615 0.20718595828261 3823 43844959
SGTC_37 0566-0070 1.56 µM -0.817887502568891 0.224727674199065 no 2616 0.206710713540364 3864 1626686
SGTC_1150 3909-7983 10.9 µM -0.818248068660178 0.224640286055176 no 2617 0.206607776320525 3844 23965914
SGTC_2064 5220758 200 µM -0.818268682410233 0.224635290612331 no 2618 0.206601892263973 3927 788518
SGTC_1913 st060213 96.1 µM -0.819293705014693 0.224386970757805 no 2619 0.206309431629319 3895 688959
SGTC_3349 9149703 23.001 µM -0.820015697112309 0.224212156008724 no 2620 0.206103579366877 3839 4910494
SGTC_2458 5808907 16.39 µM -0.820133959703872 0.224183528656715 no 2621 0.206069872296839 3959 2731747
SGTC_3274 9138298 49.47 µM -0.821349875698722 0.223889317145912 no 2622 0.205723502917515 3818 17015756
SGTC_1957 st077035 62.4 µM -0.821566302764531 0.223836971958088 no 2623 0.205661887114371 3882 705593
SGTC_1071 trifluoperazine 6.31 µM -0.823803466984206 0.223296297723998 no 2624 0.205025618668515 3962 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2950 9072895 21.46 µM -0.824143160971488 0.223214266077345 no 2625 0.204929109247652 3810 17332245
SGTC_3061 glucosamine 200 µM -0.82682343520229 0.222567616939424 no 2626 0.204168572503037 3759 91431 and experimental redox chemotherapeutic
SGTC_989 1501-0895 10.3 µM -0.826844722883089 0.222562485303374 no 2627 0.204162538789235 3811 2830112
SGTC_2665 lovastatin 100 µM -0.827213395045772 0.222473623413291 no 2628 0.204058060349275 3897 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2035 5154463 94.595 µM -0.830914245849536 0.221582720656398 no 2629 0.203011037642243 3890 2769623
SGTC_3282 9108498 15.4605 µM -0.831994538281468 0.221323047735965 no 2630 0.202706013690901 3879 16459645
SGTC_1824 st053723 68.6 µM -0.832002897707994 0.221321039035968 no 2631 0.202703654448948 3901 675225
SGTC_3095 9117207 49.47 µM -0.832117345866384 0.221293539153103 no 2632 0.202671355929269 3861 17015229
SGTC_2278 7948257 134.34 µM -0.833652839383019 0.220924776068685 no 2633 0.202238320405574 3883 1247028
SGTC_3237 9133362 49.47 µM -0.833709346216889 0.22091121213999 no 2634 0.202222395074851 3813 43845137
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.834085985883902 0.220820815545545 no 2635 0.202116265818982 3798 756377
SGTC_1048 3161-0300 24.5 µM -0.834239739849824 0.220783919427617 no 2636 0.202072950718005 3870 2165101
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.835081703465939 0.220581937238505 no 2637 0.201835853798704 3881 6708760
SGTC_2022 5136654 200 µM -0.837324219482949 0.22004448744566 no 2638 0.201205174529408 3933 1713771
SGTC_1634 st006576 41 µM -0.837668072964826 0.219962144709326 no 2639 0.20110857467735 3861 3915356
SGTC_1034 k072-0165 12.7 µM -0.838203538179767 0.219833951842828 no 2640 0.200958200126746 3914 5835461
SGTC_1811 st050069 61.5 µM -0.83885259696819 0.219678621653348 no 2641 0.200776015592611 3826 3877702
SGTC_3153 9100258 49.47 µM -0.839384775501652 0.219551309817859 no 2642 0.200626712204027 3813 25236848
SGTC_84 0443-0269 128.823 µM -0.84088427792032 0.219192815351399 no 2643 0.200206383497856 3783 6150058
SGTC_971 1315-0384 26.7 µM -0.84121069638635 0.219114821278686 no 2644 0.200114954634156 3926 6769120
SGTC_1822 st052468 42 µM -0.842415217708973 0.218827152387984 no 2645 0.199777788952594 3902 2873678
SGTC_763 3453-1109 128 µM -0.842758810884627 0.218745133860639 no 2646 0.199681674148242 3919 1560353
SGTC_428 3448-4153 16.5 µM -0.844618368181415 0.218301549270166 no 2647 0.199161975077931 3864 3834874
SGTC_902 1120-0002 2.07 µM -0.84502920871376 0.218203616031787 no 2648 0.199047265561574 3872 3280475
SGTC_1447 4239-0816 81.9 µM -0.84822468227257 0.217442766557217 no 2649 0.198156426906213 3900 1341554
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.849168576414788 0.217218316597004 no 2650 0.197893747974495 3928 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_832 4083-0019 164 µM -0.850298666726527 0.216949766888217 no 2651 0.197579528825691 3965 1990758
SGTC_3144 9087057 49.47 µM -0.854188551668637 0.216026860089526 no 2652 0.196500262708682 3759 17249618
SGTC_1738 st035555 74 µM -0.856349291999811 0.215515190961742 no 2653 0.195902301945674 3979 5331140
SGTC_6 0844-0013 19.835 µM -0.857933871459522 0.21514040543554 no 2654 0.19546448980339 4030 1584900
SGTC_1265 0819-1001 68.8 µM -0.85895420564088 0.21489927586758 no 2655 0.195182890865347 3880 3106768
SGTC_80 0159-0065 512.242 µM -0.859177258033478 0.214846584126129 no 2656 0.1951213641677 3809 1548079
SGTC_1009 4106-0057 9.87 µM -0.859585982854034 0.214750050403975 no 2657 0.195008652245846 3862 2928005
SGTC_44 0929-0055 61.211 µM -0.860773138875999 0.214469807667367 no 2658 0.194681500917622 3852 1379590
SGTC_1288 0973-0013 65.5 µM -0.861805384498431 0.214226306348782 no 2659 0.194397310703177 3959 4315430
SGTC_1261 0712-0010 12.7 µM -0.861834917686559 0.214219341992388 no 2660 0.194389183562734 3915 2840123
SGTC_1706 st031321 9.9705 µM -0.862713641873052 0.214012186288273 no 2661 0.194147465006354 3939 6103185
SGTC_593 1203-0218 61.7 µM -0.864108210816103 0.213683661734706 no 2662 0.193764224449648 3964 3666956
SGTC_2206 7254556 146.969 µM -0.864877597989459 0.213502539734378 no 2663 0.193552987225101 3944 4398905
SGTC_747 3448-8087 38.7 µM -0.865242055811623 0.213416773688645 no 2664 0.193452973438362 3952 5168703
SGTC_3182 9108849 49.47 µM -0.868436034137584 0.212666010291649 no 2665 0.192577837756717 3971 17133045
SGTC_1406 3909-7906 11.9 µM -0.868745710855162 0.212593301060114 no 2666 0.19249311660287 3936 X1406
SGTC_1032 k061-1018 98.7 µM -0.868860056239026 0.212566457491198 no 2667 0.192461839828393 4049 4005393
SGTC_282 k297-0036 65.7 µM -0.869085936414034 0.212513435982729 no 2668 0.192400064189648 3929 5061378
SGTC_1033 k072-0102 21.3 µM -0.870771518413501 0.212118018427322 no 2669 0.191939459750063 3907 5965931
SGTC_3032 9089427 49.47 µM -0.871227551051858 0.2120111125588 no 2670 0.191814959745538 3946 17173707
SGTC_1434 4073-0095 163 µM -0.871745610617948 0.211889704210463 no 2671 0.19167358597161 3889 24133745
SGTC_1660 st012960 28.1 µM -0.872514279707706 0.211709639957052 no 2672 0.191463940745046 3927 24207266
SGTC_1644 st010134 20.9 µM -0.876870180861018 0.210690943162956 no 2673 0.190278577166397 3902 3818134
SGTC_3326 9140064 16.379 µM -0.878598968815027 0.210287437057223 no 2674 0.189809377557321 3895 1868434
SGTC_22 0964-0034 14.468 µM -0.879414480087037 0.210097251052046 no 2675 0.189588291882813 3989 138402
SGTC_393 acivicin 6.25 µM -0.880375111577575 0.209873351121624 no 2676 0.189328067335163 3799 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2107 5363541 170.161 µM -0.882357519986066 0.209411743340871 no 2677 0.188791750073856 3931 244052
SGTC_2617 dihydrotanshinone i 20.83 µM -0.882645994288719 0.209344621346979 no 2678 0.188713784856174 3943 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_315 k915-0449 187 µM -0.88729235340395 0.208265255236966 no 2679 0.187460760668728 3977 20970215 YNL149C PGA2
SGTC_134 0269-0018 6.916 µM -0.887880955796191 0.208128755464616 no 2680 0.187302394903232 3916 4378915
SGTC_1322 1348-1070 12 µM -0.887930892491039 0.208117177331191 no 2681 0.187288963048537 3901 6758089
SGTC_1459 k035-0031 35.7 µM -0.888854511418255 0.207903099080272 no 2682 0.187040637586429 3777 3877128 YMR208W ERG12
SGTC_3036 9090181 49.47 µM -0.892549999928694 0.207047853219978 no 2683 0.18604910270458 3979 25236586
SGTC_1337 1486-1011 40.3 µM -0.893440740318452 0.206842021181573 no 2684 0.18581059678977 3947 X1337
SGTC_1967 st070177 51.4 µM -0.894741990774307 0.206541546409588 no 2685 0.18546251316989 4004 5729214
SGTC_181 1447-1644 8.07 µM -0.895042876069025 0.206472105107997 no 2686 0.185382084207199 3973 534600
SGTC_1338 1486-1223 76 µM -0.895614545135128 0.206340207744791 no 2687 0.185229332315498 3991 3444526
SGTC_2564 betulinic acid 100 µM -0.89572365814175 0.206315038509799 no 2688 0.185200185839892 4027 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.896089151834097 0.206230742874639 no 2689 0.185102575215508 4007 23847180
SGTC_944 3370-0224 231 µM -0.90007818254766 0.205312060885855 no 2690 0.184039322855934 4016 4580514
SGTC_2684 capsaicin 100 µM -0.90040673373779 0.205236503382114 no 2691 0.18395191930766 4002 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3316 9136639 10.545 µM -0.901327189523931 0.205024912513777 no 2692 0.183707190721239 3993 4903665
SGTC_1394 3474-0001 65.7 µM -0.901347684102349 0.205020202774374 no 2693 0.183701743981247 3953 5017666 YIL048W NEO1
SGTC_1373 2887-0003 58.5 µM -0.902664873703455 0.204717642031223 no 2694 0.183351892247976 3958 776948
SGTC_774 k060-0086 136 µM -0.905586935786695 0.204047388160775 no 2695 0.182577263085389 3933 5911235
SGTC_2622 2-methoxyxanthone 59.94 µM -0.90582616173489 0.203992573184285 no 2696 0.182513935704988 3991 71034 A hepatoprotective.
SGTC_3034 9090421 49.47 µM -0.906219001634832 0.203902578949932 no 2697 0.182409973735323 3849 17173761
SGTC_688 0527-0193 473 µM -0.906239175865408 0.203897957949167 no 2698 0.18240463578384 3996 4007154
SGTC_3125 9127534 49.47 µM -0.906877731724554 0.203751726031251 no 2699 0.182235729081504 3855 1639235
SGTC_3266 9136860 49.47 µM -0.907721979893989 0.203558485731941 no 2700 0.182012564074768 3854 4871271 YPR165W RHO1
SGTC_335 4077-0256 27.6 µM -0.908594303352 0.203358934130933 no 2701 0.181782157342259 3964 3121989
SGTC_2546 rhodinyl acetate 100 µM -0.90885564032387 0.203299173749263 no 2702 0.181713165961267 3889 6708682
SGTC_1027 k015-0025 8.67 µM -0.910766111543084 0.202862621394692 no 2703 0.1812093108607 3970 3598955
SGTC_2084 5306078 60.6385 µM -0.911378841320371 0.202722728222144 no 2704 0.181047899046061 3929 679340
SGTC_98 0074-0023 107.663 µM -0.911380107853803 0.202722439117879 no 2705 0.181047565495634 3988 3563821
SGTC_2361 9034121 116 µM -0.913810829543861 0.202168046395273 no 2706 0.180408127496047 3980 6496917
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.914090887672318 0.202104229789461 no 2707 0.180334545118355 4027 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2635 hydroquinidine 100 µM -0.914483699744748 0.202014740352664 no 2708 0.180231369543391 3912 442912 An experimental heart treatment.
SGTC_1691 st019933 84.6 µM -0.915978806695094 0.201674345909598 no 2709 0.179839005398281 3937 6176082
SGTC_1090 efavirenz 20.7 µM -0.917002439365601 0.201441491352457 no 2710 0.179570680930255 4021 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_519 k048-0011 62.8 µM -0.918181115168355 0.201173567467388 no 2711 0.179262026899192 4056 6836379
SGTC_214 4373-3496 70 µM -0.919441995947479 0.200887194319046 no 2712 0.178932215852085 4060 3779166
SGTC_3329 9141233 27.5565 µM -0.919726754518726 0.200822553397518 no 2713 0.178857783889254 3981 4909101 YNL103W MET4
SGTC_1625 st003711 30.1 µM -0.921436313155594 0.200434741720486 no 2714 0.17841133863717 4080 24207034 YER133W GLC7
SGTC_3019 9081971 49.47 µM -0.921732802994962 0.200367529096977 no 2715 0.178333982851973 4038 16451803
SGTC_3074 9116018 49.47 µM -0.924703135079257 0.199694918666597 no 2716 0.177560174108366 4058 17027303
SGTC_3268 9137683 49.47 µM -0.925158682666331 0.199591883457088 no 2717 0.177441685946482 4039 1953228
SGTC_2984 9022109 38.96 µM -0.925461622425217 0.199523382618992 no 2718 0.177362918799203 4026 6459207
SGTC_1779 st039427 55 µM -0.926914528054256 0.199195047839417 no 2719 0.17698545676524 3948 1124498
SGTC_432 NS 1619 61.3 µM -0.926967141761284 0.19918316404359 no 2720 0.176971797357626 4042 4552 A K+/calcium channel activator.
SGTC_3127 9126946 49.47 µM -0.927022531360413 0.199170653721745 no 2721 0.176957418001321 4009 27243249
SGTC_1148 3909-7663 27.7 µM -0.927243575954458 0.199120733195546 no 2722 0.176900041313742 4035 4084526
SGTC_2222 6885208 172.143 µM -0.927280396756411 0.199112418348875 no 2723 0.176890484856978 3933 609514
SGTC_2120 5538279 151.968 µM -0.927826972606772 0.198989015588318 no 2724 0.176748665142155 3986 2058197
SGTC_261 5-fluorouridine 15.376 µM -0.929760626726427 0.198552816324366 no 2725 0.176247518226804 3990 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_499 genistein 192 µM -0.93002347487675 0.198493566843373 no 2726 0.176179465122668 4051 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1208 2323-2347 50.3 µM -0.930426837718508 0.198402664221615 no 2727 0.176075064195763 4027 5412760
SGTC_650 1328-0195 38 µM -0.931575664835679 0.198143900032504 no 2728 0.175777932162243 3977 2780821
SGTC_2214 7179297 48.276 µM -0.932722612449642 0.197885762550619 no 2729 0.175481603289198 4014 769744
SGTC_422 cantharidin 155 µM -0.933868154378505 0.197628144325071 no 2730 0.175185953849318 3944 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_274 sirtinol 40.1 µM -0.936033535865799 0.197141730883977 no 2731 0.174627960673649 4073 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3345 9148410 3.559 µM -0.936423838049141 0.197054133737596 no 2732 0.174527504589631 3995 4903596
SGTC_1795 st049545 62.3 µM -0.937451422327717 0.196823621391465 no 2733 0.174263200216928 3930 5291882
SGTC_1057 3448-5381 134 µM -0.940122186568211 0.196225267641796 no 2734 0.173577444790955 4027 5497911
SGTC_921 1561-0023 372 µM -0.941487890125645 0.195919724257604 no 2735 0.173227446105266 3989 24050882
SGTC_2835 9006588 71.43 µM -0.942713716933141 0.195645720917971 no 2736 0.172913677641318 4105 2345538
SGTC_3306 9127676 59.7925 µM -0.943386330481111 0.195495473653604 no 2737 0.172741666244895 4017 41905287
SGTC_3198 9112019 49.47 µM -0.943931003329446 0.195373856926892 no 2738 0.172602453825771 4073 45595555
SGTC_489 paxilline 115 µM -0.945484443708447 0.195027251109334 no 2739 0.17220580454593 4019 105008 A toxic potassium channel blocker.
SGTC_2328 6201408 200 µM -0.945985490216918 0.194915536682908 no 2740 0.172077993485903 4033 2890418
SGTC_2718 lomofungin 53.02 µM -0.946460643277711 0.194809631472632 no 2741 0.171956843491003 4008 5351222 A RNA synthesis inhibitor.
SGTC_2471 5466956 24.79 µM -0.947319862243588 0.194618212040162 no 2742 0.171737906344661 3988 724419
SGTC_2323 6148992 148.28 µM -0.94779782229481 0.194511780194254 no 2743 0.171616194692522 4001 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_406 estrone 100 µM -0.949654354642927 0.194098704884646 no 2744 0.171143955059095 4017 5870 A steroid.
SGTC_411 enrofloxacin 100 µM -0.949958245242324 0.194031140672129 no 2745 0.171066734693217 4121 71188 A bacterial gyrase inhibitor.
SGTC_480 am 92016 50 µM -0.950418875303635 0.193928755789427 no 2746 0.170949728418116 4001 2129 K+ channel blocker.
SGTC_3160 9100216 49.47 µM -0.950923716949421 0.193816581760396 no 2747 0.170821550624016 3944 17191039
SGTC_129 0088-0017 176.636 µM -0.953182111175218 0.19331525894218 no 2748 0.170248904242212 3872 182446
SGTC_689 0833-0039 98 µM -0.956666441077266 0.192543354427174 no 2749 0.169367820865885 3995 5374726
SGTC_2031 5180455 200 µM -0.957344815577158 0.192393289462071 no 2750 0.169196621103798 3978 29949
SGTC_1759 st043059 70 µM -0.958146095146696 0.192216128505881 no 2751 0.168994547259231 4049 669426
SGTC_919 tnp00227 403.569 nM -0.959012258715924 0.192024734135836 no 2752 0.168776284814248 4014 1269246 A methoxyflavone. YNL221C POP1
SGTC_1260 0700-1617 7.75 µM -0.9605341488617 0.191688727829328 no 2753 0.168393226391982 4066 2853078
SGTC_394 menadione 8.33 µM -0.960755901647646 0.191639798826148 no 2754 0.168337458113657 4027 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3243 9134147 49.47 µM -0.960843456092813 0.191620482340096 no 2755 0.168315442447772 4100 24282180
SGTC_295 k015-0027 31 µM -0.961291751574874 0.191521596928731 no 2756 0.168202747051617 4069 3887424
SGTC_1713 st033146 12.748 µM -0.961394186900349 0.191499006043302 no 2757 0.168177003016793 4034 674619
SGTC_2099 5377090 177.372 µM -0.961513068256925 0.191472790229371 no 2758 0.168147128945601 4060 2243829
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.961613732093923 0.191450593477136 no 2759 0.168121835482181 4095 688798
SGTC_2628 lathosterol 100 µM -0.96482373961026 0.190743601828309 no 2760 0.167316551629812 4140 6710616
SGTC_169 k015-0017 16.025 µM -0.965776382485304 0.190534094635219 no 2761 0.167078044439941 4001 1840002
SGTC_337 1315-0038 354 µM -0.967008188197938 0.190263402916123 no 2762 0.166769970176522 4007 1626437
SGTC_1046 2001-0062 216 µM -0.968812406622174 0.189867349066687 no 2763 0.166319397649061 3968 739778
SGTC_2771 fluoxetine 41.05 µM -0.970632509905532 0.189468322269889 no 2764 0.165865655463698 4054 3386 A selective serotonin reuptake inhibitor.
SGTC_2864 9034755 47.6 µM -0.971192651984459 0.189345624534833 no 2765 0.165726176148789 3998 4930451
SGTC_383 2324-0395 7.37 µM -0.974065977263454 0.188716998991421 no 2766 0.165011890587446 4055 3146421
SGTC_2490 carminic acid 95.39 µM -0.97666980128748 0.188148447354009 no 2767 0.164366325127203 4021 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_601 0986-0029 62.9 µM -0.985042031855059 0.186327524177749 no 2768 0.16230171267148 4022 24747981
SGTC_465 cgp-37157 41 µM -0.987617705799501 0.185769530009062 no 2769 0.16166995577728 4012 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1745 st081495 74 µM -0.987916632551538 0.185704837694734 no 2770 0.161596739479506 3965 13842402 YBL026W LSM2
SGTC_823 0417-1665 178 µM -0.988175530742883 0.18564881946797 no 2771 0.161533344869775 4057 3429856
SGTC_2465 5809242 33.21 µM -0.988457735175506 0.185587770375585 no 2772 0.161464261893978 4097 2731748
SGTC_1255 0566-0045 221 µM -0.990123272741784 0.18522771954732 no 2773 0.16105693468054 4120 2788469
SGTC_2583 asiatic acid 100 µM -0.990438228478772 0.185159682180494 no 2774 0.1609799839314 4106 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1568 digitonin 820 nM -0.990744218464193 0.18509359648098 no 2775 0.160905246701909 4078 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2341 7987486 176.74 µM -0.993790292684057 0.184436524611332 no 2776 0.160162486531549 4122 1258686
SGTC_90 0870-0863 4.608 µM -0.996081029115956 0.183943344596141 no 2777 0.159605388284335 4095 1738164
SGTC_1164 k060-0068 93.7 µM -0.997582511608831 0.18362053157044 no 2778 0.159240922417014 4086 5963676
SGTC_3315 9136395 68.55 µM -0.997926170082554 0.183546695981962 no 2779 0.159157580389018 4093 16876844
SGTC_2405 ticlatone 3.52 µM -0.999045923903577 0.183306243428237 no 2780 0.158886222544019 3940 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2690 usnic acid 100 µM -1.00466606032711 0.182102361468544 no 2781 0.157528838031608 4133 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3227 9130768 49.47 µM -1.00704076842469 0.181595167305847 no 2782 0.156957591582274 4152 17720899
SGTC_3162 9099653 49.47 µM -1.00799165438964 0.181392323589202 no 2783 0.156729234363037 4082 25237511
SGTC_2358 9037157 4 µM -1.0081142082083 0.181366190639096 no 2784 0.156699818726729 4099 2388925
SGTC_1376 2910-0861 41.3 µM -1.00876522393702 0.181227409832647 no 2785 0.156543621428656 4043 1112859
SGTC_71 0417-1750 47.813 µM -1.01246193070259 0.180440623020432 no 2786 0.155658620037843 4115 6811472
SGTC_1328 1441-0025 69.2 µM -1.01400481637591 0.180112878464834 no 2787 0.15529022704243 4076 4562601
SGTC_1630 st005209 31.3 µM -1.01460339231468 0.179985827789103 no 2788 0.155147460823766 4067 3367314
SGTC_2971 9092186 9.93 µM -1.01623756414423 0.179639253446722 no 2789 0.154758136191753 4116 25236400
SGTC_2092 5303694 80.6725 µM -1.01740873596683 0.179391130061544 no 2790 0.154479513949534 4096 1963699
SGTC_203 k066-0004 30.888 µM -1.01773330220036 0.179322405906922 no 2791 0.154402358230694 4193 6795412
SGTC_1719 st032227 49.2 µM -1.018111167222 0.179242417044233 no 2792 0.15431256445362 4119 3125804
SGTC_585 0kpi-0023 191 µM -1.01816353150261 0.179231334012 no 2793 0.154300123617132 4054 64601
SGTC_493 zm226600 134 µM -1.02122986679693 0.178583088096835 no 2794 0.153572772581848 4158 5240098 A potassium channel opener. YCR052W RSC6
SGTC_882 0843-0131 351 µM -1.0260856699711 0.177559560328499 no 2795 0.152425602144794 4114 5425421
SGTC_210 3551-0445 56.827 µM -1.02781224230925 0.177196519770443 no 2796 0.152019078209365 4168 2865180 YOR207C RET1
SGTC_321 4534-3890 65.3 µM -1.03073797663442 0.176582406633799 no 2797 0.151331855344932 4128 699746
SGTC_2765 myclobutanil 7.74 µM -1.03153950360498 0.176414400871302 no 2798 0.151143946582394 4152 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1043 0916-0009 19.3 µM -1.03289296084572 0.176130936224725 no 2799 0.150826996651817 4165 3101130
SGTC_3 0833-0587 95.581 µM -1.03371945233103 0.175957979813819 no 2800 0.150633668265692 4025 5382644
SGTC_396 dithiazanine 1.25 µM -1.03399554885471 0.175900226223246 no 2801 0.150569122060344 4127 10578 An antihelmenthic.
SGTC_3222 9128301 49.47 µM -1.03451978233165 0.175790600637999 no 2802 0.150446616776812 4136 4911358
SGTC_1906 st060206 94.7 µM -1.03583413438808 0.175515938974209 no 2803 0.150139764976829 4161 5133468
SGTC_1990 st072050 59.8 µM -1.03660385724492 0.175355215456019 no 2804 0.149960257459047 4114 17233948
SGTC_87 0100-0052 35.5 µM -1.03699106321979 0.175274399427536 no 2805 0.149870011053677 4163 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3301 9125354 19.7965 µM -1.0370609018787 0.175259825506229 no 2806 0.149853737558337 4099 41905162
SGTC_1571 st070080 73.4 µM -1.04035546860894 0.174573189104693 no 2807 0.149087391301038 4176 4315245
SGTC_1646 st011709 75.6 µM -1.042250651838 0.174178979980291 no 2808 0.14864774249002 4077 5757843
SGTC_942 3253-1115 227 µM -1.04250043217795 0.174127066446699 no 2809 0.148589862601648 4197 46497897
SGTC_2430 5571206 200 µM -1.04533724513994 0.173538162726118 no 2810 0.147933564748335 4157 1731771
SGTC_532 1548-0774 215 µM -1.04668310274219 0.173259215370113 no 2811 0.147622879746445 4259 5932993
SGTC_3352 9151559 45.5865 µM -1.04736263550786 0.173118481462123 no 2812 0.147466178911585 4146 17159339
SGTC_2287 7945887 168.79 µM -1.04953716111338 0.172668618125943 no 2813 0.146965480624122 4159 1245853
SGTC_1329 1447-1697 50.6 µM -1.05107392907024 0.172351143226686 no 2814 0.146612318449865 4152 2840515
SGTC_1019 4262-0212 3.4 µM -1.05201207031533 0.172157519452448 no 2815 0.146397005909353 4165 4677213
SGTC_766 1391-0721 126 µM -1.05465778536681 0.17161221619583 no 2816 0.14579093262368 4184 1020919 YIL115C NUP159
SGTC_438 sphingosine 6.67 µM -1.05482610593832 0.171577561342366 no 2817 0.14575243134297 4087 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2569 tetrandrine 100 µM -1.05747625072988 0.171032523067816 no 2818 0.145147143934442 4170 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1030 k029-0042 36.7 µM -1.05823530601856 0.170876617292523 no 2819 0.144974089418729 4133 6080581
SGTC_2792 7535235 81.82 µM -1.05898121419069 0.1707235004779 no 2820 0.144804167633486 4160 1281891
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.06159644467653 0.170187351207992 no 2821 0.144209464221631 4111 16623 A steroid.
SGTC_2411 st077133 39.94 µM -1.06175680297617 0.170154511242259 no 2822 0.144173052398818 4217 1403142 YNL221C POP1
SGTC_2159 5658611 73.75 µM -1.06255774740299 0.169990545684285 no 2823 0.143991278428029 4148 793844
SGTC_81 0411-0046 9.971 µM -1.06435109539111 0.169623787359879 no 2824 0.143584839626701 4093 12925265
SGTC_2033 5192550 145 µM -1.06787351246806 0.168904895279275 no 2825 0.142788786028782 4171 182073
SGTC_3134 9127454 49.47 µM -1.06942302266628 0.168589275683905 no 2826 0.142439548922223 4209 24262820
SGTC_2491 paeonol 100 µM -1.07046307978271 0.168377639324949 no 2827 0.142205459469909 4080 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1590 st077108 57.8 µM -1.07171892034036 0.16812232201463 no 2828 0.141923149992817 4182 5489485
SGTC_3156 9099931 49.47 µM -1.0717506318449 0.168115878167608 no 2829 0.141916026249842 4191 18111053
SGTC_3060 1327-0027 12.5 µM -1.07361671299423 0.167736966246352 no 2830 0.141497251901409 4066 16000455 YPR107C YTH1
SGTC_783 0848-0141 92.7 µM -1.07400287989144 0.167658622931212 no 2831 0.141410695401357 4095 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3136 9095672 49.47 µM -1.07538077887305 0.167379274823629 no 2832 0.141102141868091 3885 17217380
SGTC_445 e6 berbamine 66 µM -1.07912738105104 0.166621225588072 no 2833 0.140265473307922 4200 6610268 A calcium/calmodulin antagonist.
SGTC_2228 7354201 200 µM -1.08437201794529 0.16556380712782 no 2834 0.13909994267039 4232 753451
SGTC_1524 corynanthine 62.1 µM -1.09047104303899 0.164339598450994 no 2835 0.137752851074756 4300 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_279 1273-0055 2.93 µM -1.09262891066322 0.163907876025953 no 2836 0.137278381910572 4197 2847562
SGTC_1312 1218-2183 165 µM -1.09478067783387 0.163478107620448 no 2837 0.136806366733673 4236 6744073
SGTC_2001 4023502 57.655 µM -1.09937232357439 0.162563476261025 no 2838 0.13580284882995 4233 108941 YCR052W RSC6
SGTC_729 4092-0585 94.1 µM -1.09994882593982 0.162448875772909 no 2839 0.135677209640581 4193 2169061
SGTC_2060 5238662 140 µM -1.10154220834653 0.16213240750795 no 2840 0.135330372450162 4184 790130
SGTC_223 busulfan 5 mM -1.10173293657994 0.162094553107692 no 2841 0.135288896723779 4197 2478 A DNA alkylator.
SGTC_1247 0448-0043 5.84 µM -1.10507253663109 0.161432665576478 no 2842 0.134564079801531 4230 3089013 YGL099W LSG1
SGTC_141 0443-0274 32.331 µM -1.10732464634909 0.160987308152311 no 2843 0.1340767960719 4187 1627241
SGTC_1645 Cervolide 78 µM -1.1074924886094 0.160954149281198 no 2844 0.134040529036571 4195 23173 A fragrance.
SGTC_1066 ketoconazole 628 nM -1.10998898750241 0.160461467971759 no 2845 0.133501885989737 4269 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2598 perillyl alcohol 100 µM -1.11227892688442 0.160010418281391 no 2846 0.133009120782217 4246 10819 An apoptosis inducer.
SGTC_418 lividomycin a 100 µM -1.11367328238615 0.159736178399076 no 2847 0.132709687639506 4236 72394 An antibiotic.
SGTC_1650 st011916 45.8 µM -1.11780924761659 0.158924532620087 no 2848 0.131824235536246 4136 242528
SGTC_2133 5320837 200 µM -1.1182616871708 0.158835909730976 no 2849 0.131727622470513 4250 2841355
SGTC_186 3455-3465 67.277 µM -1.12255371396128 0.157996808195955 no 2850 0.130813541368377 4206 755278
SGTC_179 1273-0063 6.77 µM -1.12345701580713 0.157820581895048 no 2851 0.130621723231668 4176 3108139
SGTC_1106 tegaserod maleate 11.7 µM -1.12453730593106 0.15760999630054 no 2852 0.130392576719961 4233 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2170 morpholine 200 µM -1.12616455278791 0.157293138730866 no 2853 0.130047937214176 4258 121171 Reacts with secondary amines.
SGTC_2338 7999974 200 µM -1.128354780058 0.156867319233566 no 2854 0.129585058558551 4225 315925
SGTC_877 0771-0151 33.1 µM -1.13525047686557 0.155531629741801 no 2855 0.128135192767049 4252 6166523
SGTC_1056 3448-1962 115 µM -1.13673039646668 0.155245951583749 no 2856 0.127825504129134 4219 715507
SGTC_1675 st018485 24.5 µM -1.13879257238957 0.154848454758073 no 2857 0.127394840260436 4257 3323024
SGTC_1194 1488-0194 225 µM -1.14034942907275 0.15454880702269 no 2858 0.127070376262108 4181 1391452
SGTC_537 1334-0398 209 µM -1.14096957762435 0.154429554026253 no 2859 0.126941291602 4279 5846986
SGTC_3015 9080845 49.47 µM -1.14570202804281 0.153521519664393 no 2860 0.125959232216389 4272 5296973
SGTC_2408 sulbentine 18.36 µM -1.14684975425741 0.153301834652311 no 2861 0.125721860975196 4146 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2029 5175081 200 µM -1.14743760943166 0.153189394640108 no 2862 0.125600402459094 4204 1380876
SGTC_619 1652-1634 108 µM -1.15169186069353 0.152377306337855 no 2863 0.1247238590505 4212 5400454
SGTC_403 arphamenine a 50 µM -1.15256528889982 0.152210932996303 no 2864 0.124544428668962 4216 5487158 An arginine aminopeptidase inhibitor.
SGTC_3267 9137951 49.47 µM -1.15703759436909 0.151360924720349 no 2865 0.123628500558496 4276 16643986
SGTC_1433 4060-0023 7.6 µM -1.15798704823441 0.151180878126827 no 2866 0.123434660954559 4270 3840627
SGTC_1212 0520-0165 585 µM -1.16038320949101 0.150727123652038 no 2867 0.12294640990132 4375 5403258
SGTC_3293 9120939 62.045 µM -1.16239608278626 0.150346652912607 no 2868 0.122537306863298 4249 934087
SGTC_2561 acetosyringone 100 µM -1.16782807028959 0.14932310176893 no 2869 0.121438061489522 4232 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2700 st077718 96.8 µM -1.1698612450995 0.148941189353156 no 2870 0.121028406052414 4254 904970
SGTC_2220 6782180 200 µM -1.1702381533326 0.148870462519885 no 2871 0.12095257142124 4172 833803
SGTC_1856 st057054 55.7 µM -1.17087911213064 0.148750238137524 no 2872 0.120823686117053 4275 1266018
SGTC_996 3970-0799 1.8 µM -1.17144698543364 0.148643776601981 no 2873 0.120709577775211 4258 6615648 YGL040C HEM2
SGTC_1151 3909-8316 15.3 µM -1.17153600749462 0.148627091890951 no 2874 0.120691696581695 4298 800431
SGTC_609 0986-0026 86.3 µM -1.17329714262297 0.14829727344844 no 2875 0.120338333869787 4230 2848610
SGTC_2128 5255449 168.493 µM -1.17606011250999 0.147780822643545 no 2876 0.11978542783128 4207 736008
SGTC_1813 st051246 8.6015 µM -1.17635095150387 0.147726529533274 no 2877 0.119727331555024 4210 5291959
SGTC_1360 1598-0022 39.8 µM -1.17912572191593 0.147209213893842 no 2878 0.119174058812925 4299 761525
SGTC_2138 5575593 77.673 µM -1.17932280170071 0.147172517475452 no 2879 0.119134831032377 4272 762213
SGTC_2654 protoveratrine a 100 µM -1.18012882454303 0.147022499190827 no 2880 0.11897449095186 4265 5702278 A heart drug and vasodilator.
SGTC_1564 D-Arginine 115 µM -1.18053500414755 0.14694693925249 no 2881 0.118893748442623 4281 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_440 fluspirilene 35.1 µM -1.1812512335448 0.146813765476093 no 2882 0.118751466912829 4341 3396 An atypical antipsychotic.
SGTC_3172 9105863 49.47 µM -1.18182457395717 0.14670721846008 no 2883 0.118637657504621 4338 2348785
SGTC_985 1493-0307 8.71 µM -1.18247848373086 0.146585762141365 no 2884 0.118507948990159 4285 3278274
SGTC_2593 nobiletin 86.24 µM -1.18342525795866 0.146410029193299 no 2885 0.118320326000675 4268 72344 An anti-infammatory.
SGTC_2822 7994718 71.43 µM -1.18399532754204 0.146304285511359 no 2886 0.11820745620845 4244 1018011
SGTC_2459 5811157 9.22 µM -1.18443767850835 0.14622226803109 no 2887 0.11811992628515 4234 2870684 YBR192W RIM2
SGTC_2 0422-0095 29 µM -1.18545078434168 0.146034541725418 no 2888 0.117919631332735 4170 6790840
SGTC_1629 st005085 44.9 µM -1.18824269199022 0.145518045578365 no 2889 0.117368904237931 4223 24207091
SGTC_2820 7989630 71.43 µM -1.18852651312005 0.145465608232887 no 2890 0.11731302031685 4315 2984098
SGTC_2095 5432005 200 µM -1.19267204457041 0.144701149407998 no 2891 0.1164989190876 4277 783734
SGTC_3292 9120825 59.784 µM -1.1927339160354 0.144689760500894 no 2892 0.116486799167903 4274 24824900
SGTC_2182 6325192 200 µM -1.19362770739612 0.144525304411115 no 2893 0.116311815327897 4268 736248
SGTC_2733 amorolfine 100 µM -1.19586184522634 0.144114777881456 no 2894 0.115875238359841 4422 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1490 4089-0339 670 nM -1.19692652808392 0.143919417545514 no 2895 0.115667596615914 4254 742542
SGTC_3201 9113999 49.47 µM -1.19755319696356 0.14380451263881 no 2896 0.115545502995831 4282 16649224
SGTC_1506 4226-2149 212 µM -1.19761693056747 0.143792830025466 no 2897 0.11553309093768 4293 991114
SGTC_541 4513-1321 94 µM -1.19895760609401 0.143547227482194 no 2898 0.115272215197961 4250 747515
SGTC_1058 3448-5425 97.3 µM -1.19901421072453 0.143536864136698 no 2899 0.115261209989517 4221 7279705
SGTC_588 3970-1144 52.9 µM -1.20021516921042 0.143317108080966 no 2900 0.115027892755673 4160 1888707
SGTC_983 1491-0821 12.2 µM -1.20105562359909 0.14316345367309 no 2901 0.114864812656394 4275 46495113
SGTC_3299 9121982 43.1275 µM -1.20797788316089 0.141902138551086 no 2902 0.11352788484327 4321 17594604 YPL160W CDC60
SGTC_555 4296-0685 37 µM -1.20865851100804 0.141778527887269 no 2903 0.113397033653732 4269 2908540 YHR072W ERG7
SGTC_387 norethindrone acetate 66.7 µM -1.21192869193809 0.141185638586362 no 2904 0.112769838987018 4305 541197
SGTC_1923 st058458 19.1 µM -1.21216721133007 0.14114246049241 no 2905 0.112724189974989 4303 3534982
SGTC_1233 0325-0408 14.2 µM -1.2122196364238 0.141132971413617 no 2906 0.112714158372256 4317 12874
SGTC_3158 9100007 49.47 µM -1.21347517723776 0.140905844483583 no 2907 0.112474099602391 4318 19297233
SGTC_1010 4112-3296 15.2 µM -1.21372829380664 0.140860085826878 no 2908 0.112425748113714 4338 704384
SGTC_358 0075-0058 9.45 µM -1.21874365198039 0.139955483277142 no 2909 0.111470752147591 4213 1069125
SGTC_2814 7977482 42.97 µM -1.21948617246132 0.13982189372349 no 2910 0.111329860470519 4316 6456762
SGTC_2549 cedrol 20.94 µM -1.21994732398312 0.13973896992596 no 2911 0.111242422147253 4246 6708665 A sedative which affects the nervous system.
SGTC_1973 st070275 50.2 µM -1.2216663244721 0.139430155652576 no 2912 0.110916918011971 4239 17118334
SGTC_1319 1306-0155 43.7 µM -1.22385993729677 0.139036753080033 no 2913 0.110502534507583 4348 3122360
SGTC_1558 st069300 45.6 µM -1.22480644470212 0.138867240000675 no 2914 0.110324078092414 4247 24208000
SGTC_3327 9140648 26.9345 µM -1.22549634131515 0.13874377288864 no 2915 0.110194133875331 4333 8029710
SGTC_2916 7875993 68.79 µM -1.22592621549048 0.138666878423555 no 2916 0.110113221243592 4137 1299250
SGTC_640 3381-0960 37.1 µM -1.22594440197549 0.138663625925705 no 2917 0.110109799050801 4358 1745025
SGTC_180 1486-1293 102.781 µM -1.22769391547827 0.138350983293704 no 2918 0.109780945690855 4236 4140536
SGTC_547 1120-0019 610 nM -1.22911515271215 0.138097358447506 no 2919 0.109514317345796 4262 3676939
SGTC_452 diindolylmethane 8 µM -1.2306211470824 0.137828954576628 no 2920 0.10923229611565 4302 3071 Inhibits expression of several cancer promoting factors.
SGTC_3072 9116419 49.47 µM -1.23122785632235 0.137720925260486 no 2921 0.10911882780746 4346 17170162
SGTC_3320 9137005 35.139 µM -1.23415023798065 0.13720138197124 no 2922 0.108573463128064 4353 4908713
SGTC_1367 1812-0510 76.9 µM -1.23418452007172 0.137195295229627 no 2923 0.108567077179762 4364 1142582 YDR527W RBA50
SGTC_2313 7726885 200 µM -1.23719543945282 0.13666142973674 no 2924 0.108007267115004 4330 726423
SGTC_827 3253-0474 693 µM -1.23983249563763 0.136195022144285 no 2925 0.107518678093119 4346 5402065
SGTC_107 0358-0022 2.6945 µM -1.24036674275541 0.136100664443514 no 2926 0.10741988808772 4353 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1986 st071812 45 µM -1.24669109322641 0.134987069566497 no 2927 0.106255392956406 4274 11838594
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.24869839217615 0.134634933548003 no 2928 0.105887704583738 4418 688664
SGTC_2457 5731572 11.68 µM -1.24885677206889 0.134607176172929 no 2929 0.105858732426484 4372 2865357
SGTC_1715 st032160 10.2275 µM -1.2522810689599 0.134008000458761 no 2930 0.105233732287469 4259 5289825
SGTC_3247 9135149 49.47 µM -1.25350345583479 0.1337945545114 no 2931 0.105011271094478 4365 8934436 YOR116C RPO31
SGTC_2853 9015042 58.44 µM -1.25617330833767 0.133329173659688 no 2932 0.104526570939601 4253 6457456
SGTC_113 0099-0221 2.5 µM -1.25619176893746 0.133325959682027 no 2933 0.104523225149393 4296 89219
SGTC_3067 9117431 49.47 µM -1.26449034072632 0.131886578995563 no 2934 0.103027042753596 4352 17150885
SGTC_2996 9066192 71.4286 µM -1.265619489003 0.131691560755951 no 2935 0.102824672608933 4351 6472854
SGTC_1604 st002052 72.4 µM -1.26601636021437 0.131623063345949 no 2936 0.102753612524054 4416 6254834 YHR062C RPP1
SGTC_1298 1079-1278 263 µM -1.26869956295858 0.131160604962286 no 2937 0.10227411920501 4317 2840950
SGTC_2871 9038510 12.99 µM -1.27050045585604 0.130850845586603 no 2938 0.101953210288855 4325 4945164
SGTC_734 2023-0417 80 µM -1.27230572562549 0.130540841180112 no 2939 0.101632257525612 4352 3935732
SGTC_1530 rhein 70.4 µM -1.27248888849028 0.130509416502123 no 2940 0.101599734778919 4400 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_314 1671-0008 2.74 µM -1.27504726727025 0.130071030299029 no 2941 0.101146256157913 4234 3913060
SGTC_249 wiskostatin 11.211 µM -1.27596667560253 0.129913736031904 no 2942 0.100983649715452 4328 2775510 A n-wasp and actin depolymerizer.
SGTC_1084 voriconazole 435 nM -1.27635548937883 0.129847256608507 no 2943 0.100914941524404 4363 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2282 7944268 200 µM -1.27657808216686 0.129809208272502 no 2944 0.100875621977182 4347 2970414
SGTC_2111 5486399 200 µM -1.27835210303828 0.129506246436218 no 2945 0.100562652100202 4295 689674
SGTC_1540 guanosine 70.6 µM -1.27960889461 0.129291912114576 no 2946 0.100341360048233 4264 6802 Guanosine is a purine nucleoside
SGTC_1704 st028805 70.8 µM -1.28083125698918 0.129083685345136 no 2947 0.100126471303663 4388 2876101
SGTC_874 0599-0792 117 µM -1.2817992283381 0.128918958586674 no 2948 0.0999565424902145 4359 765305
SGTC_163 TUB2.036 7.546 µM -1.28294362813764 0.128724395858472 no 2949 0.0997559132060013 4308 15992207 YJR013W GPI14
SGTC_1078 idebenone 36.1 µM -1.28304236704368 0.128707618522828 no 2950 0.0997386166915448 4389 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_962 1254-0300 21.5 µM -1.28346637270967 0.128635590355284 no 2951 0.0996643667195082 4319 7340576
SGTC_3241 9133421 49.47 µM -1.28914086664499 0.127674324541817 no 2952 0.098674559191578 4435 17018221
SGTC_533 1222-0222 6.71 µM -1.28929660002422 0.12764801371727 no 2953 0.0986474962740514 4379 3982874
SGTC_2101 5377231 179.231 µM -1.28969700699209 0.127580383113177 no 2954 0.0985779395969804 4389 2844213
SGTC_2708 st078559 56 µM -1.28990876193906 0.127544626788225 no 2955 0.0985411691142651 4303 17250902
SGTC_1089 terbinafine 2.25 µM -1.29033076825383 0.127473388809746 no 2956 0.0984679191876975 4368 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1919 st067113 52.3 µM -1.2954887807948 0.126604911287538 no 2957 0.0975758345739145 4368 1268243
SGTC_2242 6630449 61.2675 µM -1.29553472149836 0.126597194608263 no 2958 0.097567915790142 4408 691249 YDR170C SEC7
SGTC_34 0469-0683 81.75 µM -1.29561670355362 0.126583424861922 no 2959 0.0975537857415069 4318 3690923
SGTC_1648 st011736 69.8 µM -1.29618218593268 0.126488474577039 no 2960 0.0974563626827471 4354 2855514
SGTC_905 2-aminofluorene 215 µM -1.29678941318185 0.126386570158873 no 2961 0.0973518271682973 4376 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2794 7785382 27.27 µM -1.2984926352036 0.126101042029124 no 2962 0.097059052729599 4357 2205081
SGTC_2947 9072639 7.68 µM -1.30033504313195 0.125792687428213 no 2963 0.0967430812189871 4337 16488146
SGTC_2416 tofa 880 nM -1.30196972429265 0.125519539689171 no 2964 0.096463367726913 4325 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3052 9092717 49.47 µM -1.30243589689481 0.125441720288304 no 2965 0.0963837090196397 4372 25237534
SGTC_350 k064-0020 19.8 µM -1.30267008137355 0.125402639976101 no 2966 0.0963437102578207 4392 2790705
SGTC_2790 5423970 71.43 µM -1.30294918293786 0.125356075076938 no 2967 0.0962960555823885 4398 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1921 5740136 50 µM -1.3041259888864 0.125159871227788 no 2968 0.0960953145638449 4310 1774243
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.3046524362365 0.125072168362684 no 2969 0.0960056121936103 4369 5024745
SGTC_2719 novobiocin 32.65 µM -1.30489465389512 0.125031830823119 no 2970 0.0959643609523183 4418 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1698 5-fluorocytosine 1.055 µM -1.30504420477205 0.125006930015572 no 2971 0.0959388979754255 4386 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1131 3454-3128 32.3 µM -1.30811209208653 0.124496879027552 no 2972 0.0954176463207023 4393 710982
SGTC_1386 3228-0095 33.8 µM -1.31255733703529 0.123760420157009 no 2973 0.0946660767519995 4377 870181
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.31601773017205 0.123189240185822 no 2974 0.0940840459014533 4381 2346 DNA damaging agent; causes G2/M arrest.
SGTC_722 3534-0461 190 µM -1.31645772678764 0.123116745995087 no 2975 0.094010229006906 4402 658262
SGTC_3256 9138902 49.47 µM -1.31967209726876 0.122588050864797 no 2976 0.0934722599525417 4479 17228773
SGTC_1203 3992-3522 103 µM -1.32117043670952 0.122342151164089 no 2977 0.0932222706543876 4479 5322312
SGTC_2524 avocatin b 10.57 µM -1.32394999906991 0.12188690108834 no 2978 0.0927598256164662 4381 6710748
SGTC_1692 fluoroquinolonic acid 71 µM -1.32398065741681 0.12188188636107 no 2979 0.0927547343616467 4394 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2695 st077686 51.995 µM -1.32440535028866 0.121812435067884 no 2980 0.0926842293235278 4376 2876092
SGTC_1686 st019653 115.5 µM -1.32570146668049 0.121600649211039 no 2981 0.0924693007120354 4378 97252
SGTC_521 r062-0005 13.8 µM -1.32709468550162 0.121373285530666 no 2982 0.092238681562234 4312 2832033
SGTC_617 3770-0098 35 µM -1.32757749804396 0.12129456364532 no 2983 0.0921588611398636 4304 5962639
SGTC_1791 st048313 56.1 µM -1.32769152110291 0.121275977592971 no 2984 0.0921400178764542 4398 1204976
SGTC_2098 5376439 882.5 nM -1.32944235304154 0.120990838935697 no 2985 0.0918510363225283 4426 2844116
SGTC_1875 nocodazole 6 µM -1.33363506024572 0.120309937227372 no 2986 0.0911617434260743 4421 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3027 9089541 49.47 µM -1.33429160060068 0.120203559056268 no 2987 0.0910541546254339 4383 9943819
SGTC_1332 1480-0653 17.5 µM -1.33920582564911 0.119409419438 no 2988 0.0902518382228437 4384 5749438
SGTC_1006 4099-6547 255 µM -1.34219604692449 0.11892801462793 no 2989 0.0897662189477019 4402 3146833
SGTC_220 paclitaxel 373.376 µM -1.34285297954114 0.118822436939465 no 2990 0.0896597922037829 4367 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_950 1165-0508 94.1 µM -1.34585135390294 0.118341399534214 no 2991 0.0891752299390309 4378 6148369
SGTC_1381 2324-0066 62.1 µM -1.34664338036366 0.118214562744255 no 2992 0.0890475578333908 4432 10885928
SGTC_2606 farnesol 9.78 µM -1.34881017835058 0.117868058442267 no 2993 0.0886989722887523 4405 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_72 0744-0168 198.391 µM -1.3495046633401 0.117757151844545 no 2994 0.088587461743936 4289 677577
SGTC_2927 9011802 47.9 µM -1.35236290830368 0.1173014785474 no 2995 0.0881296244959811 4381 43912568
SGTC_2921 7974240 10.71 µM -1.3550099189479 0.116880596216219 no 2996 0.0877071984129575 4481 2979074 YDR527W RBA50
SGTC_1942 st076330 65.2 µM -1.35817513505942 0.116378724340762 no 2997 0.0872040592542255 4465 24208414
SGTC_2403 6032726 181.2 µM -1.35825200357384 0.116366555229595 no 2998 0.0871918671838115 4429 2881040
SGTC_1200 1643-0193 18.4 µM -1.36113990806897 0.115910022834915 no 2999 0.0867347400037552 4426 5403974
SGTC_1307 1187-1599 12.2 µM -1.36161029559313 0.115835782551425 no 3000 0.0866604521646698 4406 1538471
SGTC_2787 5284540 71.43 µM -1.36350306282765 0.115537392356935 no 3001 0.0863620099211353 4430 736958
SGTC_118 0083-0097 135.343 µM -1.36420572986274 0.115426757714548 no 3002 0.0862514126713355 4394 5207356
SGTC_2331 7980721 200 µM -1.36978479601506 0.114551007342399 no 3003 0.0853770447461561 4376 2981221
SGTC_2830 7992007 71.43 µM -1.37079825368664 0.114392433001359 no 3004 0.0852189277449042 4302 1952075
SGTC_1526 st051518 75 µM -1.3735273457744 0.113966192924488 no 3005 0.0847942330140213 4407 673993
SGTC_2332 7982454 138.89 µM -1.37790261176082 0.113285210525689 no 3006 0.0841166792397753 4325 2981748
SGTC_1725 st036284 20.55 µM -1.38564791529431 0.112086830271765 no 3007 0.0829272197850493 4458 707914
SGTC_2143 5623677 140.463 µM -1.39093988223273 0.111273267131594 no 3008 0.0821218288026078 4374 5375313
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.39269856347353 0.111003833603874 no 3009 0.0818554816014442 4470 65057 A dermal irritant. YDR527W RBA50
SGTC_1314 1222-0010 41.1 µM -1.39393989163991 0.110813941128448 no 3010 0.0816678783291065 4435 3526027
SGTC_1741 st038134 10.228 µM -1.39901785148665 0.110039562620606 no 3011 0.0809038149648652 4474 1272587
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.40082492274428 0.109764926804297 no 3012 0.0806332169508928 4380 1241132 A phosphatase inhibitor.
SGTC_3167 9103034 49.47 µM -1.40212418242456 0.109567771661596 no 3013 0.080439083468046 4521 5127859
SGTC_1096 rimcazole 32.2 µM -1.40494840916214 0.109140088996973 no 3014 0.080018310000412 4374 18528119 A dopamine reuptake inhibitor.
SGTC_610 4215-0184 155 µM -1.40546719116078 0.109061658597575 no 3015 0.079941199400738 4450 5605015
SGTC_710 3448-4187 58 µM -1.4121046338804 0.108061770794074 no 3016 0.0789595772723188 4415 3946412
SGTC_1139 k015-0024 46.9 µM -1.4130474827496 0.107920273801176 no 3017 0.0788208816246686 4469 2766652
SGTC_2812 7970281 58.44 µM -1.41742661607434 0.107264829211469 no 3018 0.078179117757519 4473 2233435
SGTC_2217 6934799 96.0675 µM -1.42195761780916 0.106589679988285 no 3019 0.0775192774749796 4427 675606
SGTC_1395 3486-0190 4.35 µM -1.42395448463428 0.106293109468238 no 3020 0.0772298240743847 4428 6748079
SGTC_36 0335-0881 14.2 µM -1.42567909904493 0.106037453310962 no 3021 0.0769804961678777 4341 23828853
SGTC_778 3456-2434 196 µM -1.42740883544594 0.105781484446876 no 3022 0.0767310427846139 4380 5539063
SGTC_7 0192-1582 4.227 µM -1.42924182761446 0.10551072341584 no 3023 0.0764673697154365 4505 252616
SGTC_3298 9116858 71.43 µM -1.42947026709795 0.105477014560623 no 3024 0.0764345574153817 4520 2506942
SGTC_3209 9113616 49.47 µM -1.43088821323029 0.105267954624123 no 3025 0.0762311278268379 4483 16649353
SGTC_1370 2001-0092 44.6 µM -1.43421816667779 0.104778170215154 no 3026 0.0757550072022807 4449 790957
SGTC_2011 4012611 177 µM -1.43491693783961 0.104675601649731 no 3027 0.075655384231673 4427 2049887
SGTC_2261 9010538 184.68 µM -1.43585072366715 0.104538650193637 no 3028 0.0755224113460739 4447 6457250
SGTC_45 0kpi-0036 14.9 µM -1.43750320752738 0.104296610817226 no 3029 0.0752875310417887 4436 2795021
SGTC_506 n9-isopropylolomoucine 153 µM -1.44470796724099 0.103246074828316 no 3030 0.0742699655337087 4452 6610355
SGTC_2018 5133068 143 µM -1.45080317451654 0.102363341197462 no 3031 0.0734173377288216 4430 785362
SGTC_1489 4065-0444 182 µM -1.45122512571854 0.102302436195142 no 3032 0.0733585913146745 4473 2877968
SGTC_1404 3909-7820 48.3 µM -1.45915062349116 0.101163351896231 no 3033 0.0722618277327943 4474 23741373
SGTC_1274 0865-0114 173 µM -1.46195917720242 0.100761921571575 no 3034 0.0718761984629585 4464 870624
SGTC_4 0960-0234 25.671 µM -1.46428493628113 0.100430378021667 no 3035 0.0715580556441725 4470 6821112
SGTC_2034 5197015 53.07 µM -1.46588304812999 0.100203024509284 no 3036 0.0713400754614769 4468 780676
SGTC_2929 9013348 24.6 µM -1.47302253524171 0.0991919215040065 no 3037 0.0703724797030686 4452 2995952
SGTC_703 3875-0075 71.8 µM -1.47416581950806 0.0990307036591153 no 3038 0.0702184751810652 4515 2850814
SGTC_2273 7815444 169.05 µM -1.47464399800742 0.0989633311929466 no 3039 0.0701541397406093 4417 2824616
SGTC_772 k072-0172 35.3 µM -1.47590220435102 0.0987862177097599 no 3040 0.0699850738318096 4523 5861980
SGTC_2785 7756463 72.73 µM -1.47592338421337 0.0987832382781305 no 3041 0.0699822305668658 4456 2201551
SGTC_2037 5169046 200 µM -1.47938852537919 0.0982966720354344 no 3042 0.0695182525610693 4537 5718022
SGTC_2181 6316240 54.2555 µM -1.4823076237474 0.0978881438305324 no 3043 0.0691292303460781 4492 12779990
SGTC_255 tunicamycin 200.472 nM -1.48362016670331 0.0977048593815586 no 3044 0.0689548581072365 4404 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_670 4204-0025 119 µM -1.48538983532355 0.0974581400587202 no 3045 0.0687202933587576 4494 719039
SGTC_1143 3454-2408 5.08 µM -1.48571664292502 0.0974126280274682 no 3046 0.068677043287452 4491 X1143
SGTC_1044 1222-0021 1.78 µM -1.48572901092831 0.097410905935104 no 3047 0.0686754069048655 4406 4306703
SGTC_2369 9071472 200 µM -1.48819410256412 0.0970681178812169 no 3048 0.0683498560458428 4499 17296037
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.49105434003411 0.0966714926841258 no 3049 0.0679736143843001 4511 77254
SGTC_1435 4092-0789 56.7 µM -1.49117009763969 0.0966554658354184 no 3050 0.0679584211222916 4487 2248285
SGTC_1816 st051957 91.6 µM -1.49361929176144 0.0963168278491741 no 3051 0.0676375770879662 4495 674121
SGTC_227 fluconazole 33.516 µM -1.49696307331967 0.0958559086740316 no 3052 0.0672014333641349 4494 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_819 1013-0258 27.7 µM -1.50170065146373 0.0952056441092478 no 3053 0.0665872177920293 4493 5753198
SGTC_2965 9082772 38.63 µM -1.50335772973116 0.0949789674487462 no 3054 0.0663734103348718 4491 16459634
SGTC_1819 st053448 58.6 µM -1.50442111978234 0.0948337127438174 no 3055 0.0662364848227733 4433 2857616
SGTC_853 0419-0306 21 µM -1.50711372720295 0.0944666457409769 no 3056 0.0658907543858815 4508 762713
SGTC_1925 st057770 10.1 µM -1.50785032461881 0.0943664125638488 no 3057 0.0657964194155521 4492 5989122
SGTC_1843 st055809 45.5 µM -1.50806408140875 0.0943373400976833 no 3058 0.0657690634977281 4533 16413835
SGTC_173 1273-0061 2.693 µM -1.50824479472836 0.0943127669351059 no 3059 0.0657459432566716 4452 2847414 YPL266W DIM1
SGTC_1621 st003705 32.4 µM -1.51214613372855 0.0937834184077441 no 3060 0.0652483454092593 4504 24207032
SGTC_2247 cerulenin 830 nM -1.51532004722211 0.0933543902538023 no 3061 0.0648456869446603 4513 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1842 st055362 61.2 µM -1.51554819355403 0.0933236069250313 no 3062 0.0648168176543025 4461 676032
SGTC_3084 9116877 49.47 µM -1.51695276341463 0.09313425630601 no 3063 0.0646393053009805 4455 27241325
SGTC_2566 crystal violet carbinol 226 nM -1.52082144517827 0.0926141860258454 no 3064 0.0641523256379522 4464 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.52166432628791 0.0925011623285149 no 3065 0.064046605281372 4509 5377381
SGTC_408 cantharidin 100 µM -1.52228183596998 0.0924184239488173 no 3066 0.0639692386780609 4490 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1488 4013-0813 75.9 µM -1.52675967210103 0.0918200890346958 no 3067 0.0634103915227315 4495 2910057
SGTC_363 0455-0021 3.06 µM -1.5271059088275 0.0917739441735012 no 3068 0.0633673389357383 4448 4597466
SGTC_1411 3909-8223 150 µM -1.52823460432051 0.0916236360377558 no 3069 0.0632271499872047 4541 X1411
SGTC_1893 st059353 36.1 µM -1.52853421384191 0.0915837677560967 no 3070 0.0631899777544091 4503 3112488
SGTC_287 k060-0039 29.6 µM -1.52994475393956 0.0913962434676051 no 3071 0.0630152021595042 4550 5861974
SGTC_1602 st001878 87.6 µM -1.531491369189 0.0911909559674885 no 3072 0.0628239989434657 4490 595405 YLR310C CDC25
SGTC_2132 5317594 122.667 µM -1.53202890267129 0.0911196874498444 no 3073 0.0627576513176979 4454 794577
SGTC_618 k072-0232 33.2 µM -1.53413045494029 0.090841450972622 no 3074 0.062498781166081 4540 5872756 YGL099W LSG1
SGTC_2642 cholecalciferol 100 µM -1.53551692987656 0.0906582331067839 no 3075 0.0623284508683382 4518 9821465 A vitamin D precursor, similar to steriods.
SGTC_2701 st077767 14.721 µM -1.53559563143536 0.0906478412003787 no 3076 0.0623187931455559 4477 5721188
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.54294119913874 0.0896818061225979 no 3077 0.0614225217221705 4561 165521
SGTC_1678 st019265 80.2 µM -1.54631852151028 0.0892402228440097 no 3078 0.0610138305054758 4497 5367020
SGTC_2184 6075246 200 µM -1.54960751596632 0.0888117452723938 no 3079 0.0606178739475669 4506 2267320
SGTC_3016 9080866 49.47 µM -1.54991717723592 0.0887714828294825 no 3080 0.0605806981172188 4495 17066299
SGTC_2449 5812982 45.77 µM -1.55456577340987 0.0881687006698199 no 3081 0.0600247602758365 4458 776185
SGTC_909 3448-9333 149 µM -1.55564960324705 0.0880286003959448 no 3082 0.0598957182971013 4449 3344074
SGTC_284 0988-0104 32.6 µM -1.55565799502009 0.0880275162890276 no 3083 0.0598947200117087 4507 4666532
SGTC_2464 5717415 7.67 µM -1.55593859388087 0.0879912723309596 no 3084 0.0598613474714907 4492 5285744
SGTC_349 k015-0014 24 µM -1.55884636640584 0.0876163405961485 no 3085 0.0595163735197092 4529 2196908
SGTC_97 0535-0701 19.132 µM -1.56405520544747 0.0869476889179222 no 3086 0.0589023021913432 4426 2832013 YGL099W LSG1
SGTC_2155 5570423 76 µM -1.56576948651615 0.0867284647846293 no 3087 0.0587012960646431 4522 797402
SGTC_3079 9117512 49.47 µM -1.56583900671832 0.0867195831886 no 3088 0.0586931559245795 4612 7185044
SGTC_3347 9188721 44.724 µM -1.56824079911296 0.086413157961537 no 3089 0.0584124730823119 4532 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1342 1486-1464 234 µM -1.57035170286647 0.0861445139446054 no 3090 0.0581666559657983 4534 3253938
SGTC_177 1327-0068 8.361 µM -1.57090399215473 0.0860743301095001 no 3091 0.0581024755862361 4521 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_464 bw-b 70c 158 µM -1.57139890458188 0.0860114739649241 no 3092 0.0580450101374233 4527 5353454
SGTC_104 0074-0074 590.992 µM -1.57249060673005 0.085872944239916 no 3093 0.0579184079556136 4391 3943124
SGTC_2951 9072950 58.06 µM -1.57301979511146 0.0858058538819039 no 3094 0.0578571173548172 4448 16488155
SGTC_299 1273-0059 1.44 µM -1.57429074816971 0.0856448830798225 no 3095 0.0577101238432561 4310 2848077
SGTC_1941 st076221 61.8 µM -1.58329056478271 0.0845114872552511 no 3096 0.0566776262278448 4427 2828568
SGTC_1605 st000082 49.1 µM -1.58536935952194 0.0842513002708169 no 3097 0.0564412193033188 4493 1114022
SGTC_1498 4478-3555 97.6 µM -1.58575657339789 0.0842029021376632 no 3098 0.0563972701347024 4544 3437919
SGTC_2355 9061122 103.12 µM -1.58840629761058 0.0838722711154291 no 3099 0.0560972471724599 4549 5302957
SGTC_2207 7258803 200 µM -1.59230663275066 0.0833873648482361 no 3100 0.0556579116739426 4565 3666799
SGTC_79 0052-0007 94.094 µM -1.59286844938557 0.0833176913946574 no 3101 0.0555948527573573 4520 2801472
SGTC_1427 4048-4900 550 nM -1.59397414632905 0.0831806966859451 no 3102 0.0554709128336252 4518 24132586
SGTC_3337 9144342 33.5465 µM -1.59514184403967 0.0830362041054893 no 3103 0.0553402600529768 4543 17682949
SGTC_3080 9117754 49.47 µM -1.59543123500358 0.083000423661909 no 3104 0.0553079179302186 4537 9550191
SGTC_2823 7987624 58.44 µM -1.59543874598369 0.082999495154994 no 3105 0.0553070787073515 4491 2239440
SGTC_1642 st009582 77.7 µM -1.60010404634233 0.0824242792604594 no 3106 0.05478775175302 4532 6739311
SGTC_2043 5101342 149 µM -1.60961832175384 0.0812605109229494 no 3107 0.053740602950028 4575 678451
SGTC_59 0330-0160 1.33 µM -1.60985338311375 0.0812319163924699 no 3108 0.0537149339689961 4498 4293482
SGTC_158 k038-0087 26.446 µM -1.61082790050306 0.0811134501609966 no 3109 0.0536086190735902 4461 X158
SGTC_153 4077-0274 519.67 µM -1.61715657577989 0.0803472816810928 no 3110 0.0529222435495364 4563 3121976
SGTC_2379 9035213 200 µM -1.61804876722726 0.0802397115692446 no 3111 0.05282604415579 4558 646551
SGTC_1996 st072960 66.8 µM -1.62093614125305 0.0798923315310561 no 3112 0.052515667415065 4580 1719405
SGTC_1761 st044296 37 µM -1.6336560648821 0.0783755275776638 no 3113 0.0511655442419127 4569 1826700
SGTC_366 0181-0206 4.31 µM -1.63663080046743 0.0780239721433672 no 3114 0.0508538179615129 4545 274874
SGTC_862 0452-0056 10.2 µM -1.63721414990351 0.0779551722035747 no 3115 0.0507928657415279 4512 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_116 0155-0182 31.788 µM -1.63963728588069 0.0776698814326231 no 3116 0.0505403028480056 4423 771486
SGTC_2139 5578692 56.4705 µM -1.64108494461249 0.0774998182530062 no 3117 0.0503898917523743 4552 650991 YMR113W FOL3
SGTC_2399 5884133 200 µM -1.64229372582454 0.0773580338765672 no 3118 0.0502645733770853 4512 722445
SGTC_2233 sulbentine 40.3845 µM -1.64882379758582 0.0765954922013968 no 3119 0.0495918690524426 4588 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2267 7931562 200 µM -1.65033690397342 0.0764196195014557 no 3120 0.0494370241492917 4529 934880
SGTC_2696 st077691 74.316 µM -1.65594870256425 0.0757700261391166 no 3121 0.048866103787649 4574 757133
SGTC_1889 st059080 5.18 µM -1.65673759474578 0.0756790461672246 no 3122 0.0487862693581783 4545 176925 Isolated from Daphnopsis sellowiana.
SGTC_563 tetrahydrosecaminediol 614 µM -1.66582647093148 0.0746368546059579 no 3123 0.0478739910778784 4624 334274 A psychoactive constituent of the cannabis plant.
SGTC_2759 disulfiram 3.38 µM -1.66815817022998 0.0743712599827254 no 3124 0.0476421660806498 4481 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_569 4130-2812 160 µM -1.66874320626779 0.0743047342282528 no 3125 0.0475841412466625 4460 743552
SGTC_1734 st037168 69.4 µM -1.66913468373281 0.0742602438351264 no 3126 0.0475453454917843 4569 708907
SGTC_3024 9090631 49.47 µM -1.66963506080378 0.0742034069089382 no 3127 0.0474957945872448 4559 25236383
SGTC_914 3820-6779 408 µM -1.67037757145807 0.0741191277065145 no 3128 0.0474223421430015 4501 2893481
SGTC_1451 4152-0210 104 µM -1.67041354386219 0.0741150464908919 no 3129 0.0474187859062274 4601 659563
SGTC_3228 9131799 49.47 µM -1.68522809597167 0.0724488241838271 no 3130 0.0459722861726961 4600 17015818
SGTC_1123 mangostin 811.285 nM -1.68635959459765 0.072322751536533 no 3131 0.0458632794701711 4578 5281650 An antioxidant.
SGTC_1970 st070122 35.8 µM -1.68646481428506 0.072311036408028 no 3132 0.0458531533440213 4597 102928
SGTC_2652 actinonin 100 µM -1.68997039964197 0.0719215563181353 no 3133 0.0455168088677863 4628 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_799 1310-0557 151 µM -1.69039920908107 0.0718740250505284 no 3134 0.0454758031396776 4605 5354492
SGTC_2492 derrusnin 100 µM -1.69617045269386 0.0712366546882204 no 3135 0.0449268021929611 4615 1715307 Part of coumarin class of compounds.
SGTC_2005 4024620 188 µM -1.69741074355436 0.071100246409634 no 3136 0.0448095164017461 4546 236743
SGTC_2116 5511452 16.8835 µM -1.69901671051935 0.0709239188676019 no 3137 0.0446580175474608 4591 870744
SGTC_1775 st081588 35.1725 µM -1.7107764082942 0.0696429789684672 no 3138 0.0435611981257716 4568 1426443 YGL099W LSG1
SGTC_2404 5161160 200 µM -1.71554399354177 0.0691287668312805 no 3139 0.0431227683815297 4551 2831543
SGTC_2208 7283366 200 µM -1.71643195381353 0.0690333191040146 no 3140 0.0430415061647099 4591 898663
SGTC_643 k048-0106 28.4 µM -1.71734648348821 0.0689351216110543 no 3141 0.0429579418011094 4625 6763920
SGTC_3050 9093513 49.47 µM -1.72099049915795 0.0685449149239218 no 3142 0.0426262739709486 4551 25236664
SGTC_2817 7995342 71.43 µM -1.72255252102819 0.0683781738734961 no 3143 0.0424847386319093 4571 18879975
SGTC_2845 9003024 42.97 µM -1.72520253028636 0.0680960095927571 no 3144 0.0422454899323976 4606 2990173
SGTC_2225 6654152 15.4 µM -1.7316371217218 0.0674146168462434 no 3145 0.0416690962088578 4551 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_965 1291-5240 308 µM -1.73238322680916 0.0673359500121625 no 3146 0.0416026761999971 4593 2834598
SGTC_565 1418-0001 44.5 µM -1.73855849353441 0.0666875720218843 no 3147 0.0410562263896066 4638 2862145
SGTC_1958 st076513 41.9 µM -1.74049489045777 0.0664852563748766 no 3148 0.040886078244996 4537 732122 YGL099W LSG1
SGTC_53 0973-0023 39.979 µM -1.74216652135715 0.06631098604276 no 3149 0.0407396551407363 4534 674768
SGTC_2880 9042983 58.44 µM -1.74887752343686 0.0656149116031948 no 3150 0.0401560962913191 4559 6464714
SGTC_266 formosanin C 406 nM -1.74945258816295 0.0655555296155782 no 3151 0.0401064087163845 4463 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_717 1532-0246 73.2 µM -1.75226755033424 0.065265453761203 no 3152 0.039863906521857 4606 9561992
SGTC_2563 tomatine 8.54 µM -1.7545394792213 0.0650320633342887 no 3153 0.0396690556610115 4537 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1702 st027038 51 µM -1.75871260071175 0.0646050557451706 no 3154 0.0393131680250427 4642 5521182
SGTC_540 1187-0821 17.3 µM -1.76300768967671 0.064167845512979 no 3155 0.038949596369648 4548 847520
SGTC_3249 9135183 49.47 µM -1.76433144778376 0.0640335608153053 no 3156 0.0388380961603212 4559 4902779
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.76453016649927 0.0640134212629869 no 3157 0.0388213805376972 4575 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_571 k831-0106 44.2 µM -1.76962876208401 0.0634983762094457 no 3158 0.0383945021123441 4518 4783639
SGTC_3339 9145883 14.936 µM -1.7708641278721 0.0633740698986806 no 3159 0.0382916494239856 4546 2030670
SGTC_1390 3413-2614 145 µM -1.7723778059784 0.0632220172877671 no 3160 0.0381659317078219 4611 3421432
SGTC_3189 9110682 49.47 µM -1.77841908627253 0.0626179838912628 no 3161 0.0376675251346879 4612 17122418
SGTC_2320 7373003 200 µM -1.77900096398958 0.0625600435442861 no 3162 0.0376198019592538 4590 5415828
SGTC_1831 st055328 12 µM -1.78097433804306 0.0623638564260158 no 3163 0.0374583215429632 4597 1103068
SGTC_2157 5649910 96.377 µM -1.80407825322479 0.0601024673938894 no 3164 0.0356095201761038 4610 2858091
SGTC_644 1498-1197 63.3 µM -1.80469317894414 0.0600431680722738 no 3165 0.0355613539016943 4663 6741615
SGTC_2674 ligustilide 100 µM -1.81100456821244 0.0594371849678685 no 3166 0.0350700722670443 4666 5319022 A signalling regulator.
SGTC_2777 climbazole 1.536 µM -1.81221473312642 0.0593215415803313 no 3167 0.0349765117222458 4412 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1280 0880-0253 10.1 µM -1.81244786321682 0.0592992839428053 no 3168 0.0349585114707377 4630 6836607
SGTC_256 clotrimazole 625 nM -1.81251149047077 0.059293210393279 no 3169 0.0349536000557874 4580 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1641 st009299 47.1 µM -1.81913371668162 0.0586637476402801 no 3170 0.0344455161115209 4582 4046054
SGTC_3229 9132204 49.47 µM -1.82909700959129 0.0577266036906581 no 3171 0.0336925384408878 4715 17682924
SGTC_3135 9127742 49.47 µM -1.83565924304527 0.0571158197520726 no 3172 0.0332040346715282 4668 3643468
SGTC_1968 st069590 43.6 µM -1.83919920165521 0.0567884545734682 no 3173 0.0329429460364041 4608 6384066
SGTC_2223 6903751 107.57 µM -1.84248009851686 0.0564863679564883 no 3174 0.0327024774827597 4620 5598863
SGTC_2376 9072922 81.32 µM -1.84656780991473 0.0561117677947757 no 3175 0.0324049015696736 4627 17087968
SGTC_2297 7971671 152.32 µM -1.85844720252952 0.0550342459849271 no 3176 0.0315527672214355 4624 909016
SGTC_1786 berberine 21.6 µM -1.86076334153219 0.0548260773713742 no 3177 0.0313888022218851 4569 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1182 1222-0449 220 µM -1.86996644013292 0.0540050700255941 no 3178 0.0307442391752909 4660 658318
SGTC_634 1611-4317 11.2 µM -1.87011179485209 0.0539921814514123 no 3179 0.030734147454009 4670 2843522
SGTC_1951 sophoraflavanone G 9.2 µM -1.87072917937348 0.0539374652214357 no 3180 0.0306913140978622 4596 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2047 4141938 200 µM -1.87124436774287 0.0538918398216771 no 3181 0.0306556088263016 4668 3807862
SGTC_810 3825-7150 143 µM -1.88237708902592 0.0529133639752306 no 3182 0.0298924171973575 4650 22330411 YGL099W LSG1
SGTC_2072 5231554 129 µM -1.8871009533493 0.0525024562527026 no 3183 0.0295733742557111 4708 789545
SGTC_1887 st057648 70.8 µM -1.89094520694945 0.0521699347118442 no 3184 0.0293158294544243 4656 688672
SGTC_676 falcarinol 140 µM -1.90233982736752 0.0511941385426795 no 3185 0.0285633710426064 4662 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3147 9097027 49.47 µM -1.91353129423531 0.0502499310210716 no 3186 0.0278400356005226 4664 25236841
SGTC_2462 5162487 171.77 µM -1.91424687063202 0.0501900341856063 no 3187 0.0277943097323534 4653 2259986
SGTC_1359 1582-0056 520 nM -1.92069308732458 0.0496530201471933 no 3188 0.0273852058072074 4706 3661189
SGTC_876 0720-0963 56.8 µM -1.92171394199273 0.0495683980374005 no 3189 0.0273208809861278 4671 765861
SGTC_960 1222-0186 7.7 µM -1.92636340803524 0.0491844428503225 no 3190 0.0270295065531176 4649 3126296
SGTC_1414 3917-0015 5.4 µM -1.92809602295951 0.0490419715836692 no 3191 0.0269215917904059 4674 6618702
SGTC_2253 7938677 135.83 µM -1.93185175464435 0.0487342732158686 no 3192 0.0266889030077723 4686 2301972
SGTC_1364 1653-0028 37.6 µM -1.93917840516509 0.0481384601193657 no 3193 0.0262398090919918 4679 5718652
SGTC_1814 st052110 31.539 µM -1.93949259552481 0.0481130406533073 no 3194 0.026220692637994 4611 674163
SGTC_920 mycophenolic acid 780.421 nM -1.94523749264061 0.0476501426618574 no 3195 0.025873200660214 4649 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_586 0957-0265 8.15 µM -1.95051527307482 0.0472280329213787 no 3196 0.0255573673975945 4592 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2344 7990960 76.95 µM -1.95124315305749 0.0471700539671368 no 3197 0.0255140639240432 4645 140813
SGTC_1560 lithocholic acid 53.1 µM -1.95301632990739 0.0470290511448142 no 3198 0.0254088301159401 4624 9903 A bile acid which acts as a detergent.
SGTC_2378 9074213 121.43 µM -1.9557831919158 0.0468097059217588 no 3199 0.0252453498539031 4664 657714
SGTC_1909 st060837 51.5 µM -1.95711586298981 0.0467043505590132 no 3200 0.0251669239066186 4629 678937
SGTC_1720 st037298 9.481 µM -1.96094800059441 0.0464024576868233 no 3201 0.0249425445454298 4648 597396
SGTC_3082 9117008 49.47 µM -1.96150054476181 0.0463590581896073 no 3202 0.0249103307577307 4683 41448529
SGTC_1023 4482-3888 16 µM -1.96490088765435 0.0460926956552915 no 3203 0.0247128549919251 4668 3303168
SGTC_127 0180-0333 59.125 µM -1.96980508632799 0.0457106965702448 no 3204 0.0244303567167366 4605 771601
SGTC_3006 9075424 71.4286 µM -1.96982279670721 0.0457093216945907 no 3205 0.0244293414728675 4645 7465181
SGTC_683 panaxydol 45 µM -1.97285245920914 0.0454746145407935 no 3206 0.0242561871813148 4680 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_67 0335-0847 266 µM -1.97533816297119 0.0452827723431344 no 3207 0.0241148925680216 4644 4552207 YOR254C SEC63
SGTC_2354 9060492 162 µM -1.97730269079804 0.0451316146423311 no 3208 0.0240037128555952 4666 6471895
SGTC_2384 9036245 200 µM -1.98016672302246 0.0449119736335299 no 3209 0.0238423988642335 4664 6462766
SGTC_2062 5245942 200 µM -1.98304339954754 0.0446922299742767 no 3210 0.0236812910025649 4705 1376160
SGTC_2709 st078560 56 µM -1.98575532517461 0.0444858650251129 no 3211 0.0235302492693653 4649 17250903
SGTC_1793 st048256 72.231 µM -1.98614617147432 0.0444561868321799 no 3212 0.0235085478930005 4688 672022
SGTC_2659 sanguinarine 24.21 µM -1.99089901553508 0.0440965633809623 no 3213 0.0232459952353634 4656 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3057 9095946 49.47 µM -1.99280012965846 0.0439533741158081 no 3214 0.0231416687851005 4709 24540043
SGTC_1591 genipin 88.4 µM -1.99446268892966 0.0438284600406767 no 3215 0.0230507567733371 4666 442424 A DNA cross-linking agent.
SGTC_52 0329-0193 875 nM -1.99806192531932 0.0435590174394188 no 3216 0.0228549734672214 4684 3739292
SGTC_455 paf C-16 10 µM -2.01514218929657 0.0422985435647501 no 3217 0.0219448763930507 4670 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_372 0155-0182 15.9 µM -2.01546648049258 0.0422749003447184 no 3218 0.0219278973883299 4578 771486
SGTC_2285 7945142 200 µM -2.01996700793552 0.0419478812655087 no 3219 0.0216934049111306 4676 2970608
SGTC_1527 coumarin 137 µM -2.02469900935494 0.0416062545073371 no 3220 0.0214491402105534 4699 323 A hepatotoxic, DNA x-linker.
SGTC_1815 st051655 58.2 µM -2.02660648097776 0.0414691835735297 no 3221 0.0213513366188186 4678 5984156
SGTC_2299 7976368 114.88 µM -2.03927575935951 0.0405680302976432 no 3222 0.0207112567672714 4674 2979718
SGTC_1510 1123-0200 71.5 µM -2.06611726846656 0.0387113146053188 no 3223 0.0194087040369744 4690 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1852 st056254 31.4 µM -2.06794030355844 0.0385877619821742 no 3224 0.0193228184571799 4689 442583
SGTC_966 1300-0360 30.2 µM -2.06973442276612 0.0384664829945665 no 3225 0.0192386106720036 4687 70588
SGTC_1878 temozolomide 1 mM -2.07100180708538 0.0383809976595854 no 3226 0.0191793135907051 4673 5394 DNA alkylating agent.
SGTC_1171 0368-0077 21.4 µM -2.07274488157927 0.0382636799595577 no 3227 0.0190980142351592 4692 3239779
SGTC_362 0310-0100 9.03 µM -2.07417866089448 0.0381673987078491 no 3228 0.0190313606386855 4700 790235
SGTC_2836 9010338 19.48 µM -2.07724055876946 0.037962447390872 no 3229 0.0188896810925061 4642 2994051
SGTC_1603 st002045 67.8 µM -2.09860336064979 0.036557368195267 no 3230 0.0179259399360379 4712 5887985
SGTC_3210 9128157 49.47 µM -2.12821123090008 0.0346806268628923 no 3231 0.0166597870386483 4641 17590849
SGTC_1860 st056228 74.6 µM -2.13212657346941 0.0344384777593869 no 3232 0.0164982213086337 4704 688679
SGTC_1700 st030840 7.9285 µM -2.14204207984574 0.0338314500855377 no 3233 0.0160950480138558 4740 5499307
SGTC_1179 1021-1431 9.29 µM -2.14291225431827 0.0337786007438175 no 3234 0.016060072398694 4720 2840958
SGTC_743 1275-0778 158 µM -2.15871770147859 0.0328304336403384 no 3235 0.0154360373151062 4713 2849257 YMR203W TOM40
SGTC_252 miconazole 1.30953 nM -2.16067222005883 0.0327147216123173 no 3236 0.0153603341417415 4651 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2838 9002687 71.43 µM -2.16286714824179 0.0325851778604747 no 3237 0.0152756995789338 4690 6457060
SGTC_2541 muurolladie-3-one 83.07 µM -2.17579308155831 0.0318308503651217 no 3238 0.0147853681247632 4676 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2020 4017018 200 µM -2.18036734949502 0.0315673865827208 no 3239 0.0146151211850884 4709 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1468 k284-1086 134 µM -2.18240439610057 0.0314506403604759 no 3240 0.0145398500861366 4710 15996457
SGTC_3170 9103054 49.47 µM -2.18617614725888 0.031235417948845 no 3241 0.0144013603275751 4694 16432970
SGTC_2651 TUB2.036 5 µM -2.18698475332743 0.0311894364638641 no 3242 0.0143718185219735 4602 15992207 YFL037W TUB2
SGTC_1950 st077106 7.18 µM -2.21140864997034 0.0298267394527973 no 3243 0.0135037756938897 4666 13831864
SGTC_2858 9025781 8.96 µM -2.21563540325691 0.0295960018736025 no 3244 0.0133582410848247 4554 4894980 YPL153C RAD53
SGTC_1273 0849-0096 14.1 µM -2.2211579586702 0.0292967609480711 no 3245 0.0131701322879664 4725 5286025
SGTC_2889 9059656 51.95 µM -2.22369831744198 0.0291599571704295 no 3246 0.0130843742593045 4743 3949838
SGTC_3063 1327-0034 4 µM -2.22818935277382 0.0289194037629151 no 3247 0.0129339453886585 4630 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2434 5670830 169.91 µM -2.23569076316081 0.0285212849632336 no 3248 0.0126860172540677 4722 1549830
SGTC_12 0849-0099 9.267 µM -2.244526287752 0.02805821971324 no 3249 0.0123992797454383 4721 6071388
SGTC_1116 jasmonic acid 1.58368 µM -2.24553917780218 0.0280055369224454 no 3250 0.012366770041957 4763 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1762 st045503 25.4615 µM -2.26489600485617 0.0270144696328767 no 3251 0.0117595310022855 4733 4645554
SGTC_2721 ifenprodil 61.44 µM -2.26601194048886 0.0269582377573558 no 3252 0.0117253260890865 4717 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1113 artemisinin 1.17947 µM -2.28231016360333 0.0261480456032835 no 3253 0.011235517459272 4747 2240 An anti-malaria and mitochondrial poison.
SGTC_1100 amiodarone 5.07 µM -2.30846157842835 0.0248906428831179 no 3254 0.0104867387248013 4743 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2377 9073351 62.6 µM -2.31979845945013 0.0243615181992042 no 3255 0.0101758912321776 4725 7337946 YHR072W ERG7
SGTC_1059 3448-6867 171 µM -2.32361513033227 0.0241855217285377 no 3256 0.0100730653867989 4715 3934407
SGTC_2450 5739737 12.93 µM -2.32498396738436 0.0241226618912639 no 3257 0.0100364087533919 4735 2262825
SGTC_548 1436-0017 110 µM -2.32804351393894 0.0239826572540158 no 3258 0.00995489660294846 4761 9677137
SGTC_156 3474-0145 5.642 µM -2.33705311281436 0.0235743388958217 no 3259 0.00971821128207109 4694 2265471
SGTC_3353 9151644 39.2805 µM -2.35807149674295 0.0226444629952286 no 3260 0.00918507724427126 4748 4909158
SGTC_3062 9077494 49.47 µM -2.37745525691918 0.0218144989758788 no 3261 0.00871627887313496 4696 16459633
SGTC_2105 5350118 200 µM -2.40382928366719 0.0207266095365278 no 3262 0.00811217397555348 4743 2133313
SGTC_1196 1588-0294 184 µM -2.41436729678237 0.0203049627770979 no 3263 0.007881281829053 4770 6144269
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.42631175112627 0.0198358554327835 no 3264 0.00762658064829805 4740 17037758
SGTC_2905 7799065 20.05 µM -2.44557583312338 0.0190986642547958 no 3265 0.00723105158095169 4715 1296806
SGTC_2656 pseudo-anisatin 100 µM -2.4477814875321 0.0190157645694761 no 3266 0.00718693993747905 4790 6708809 A neurotoxin.
SGTC_1428 4049-0204 61.7 µM -2.4527250662761 0.0188310707789524 no 3267 0.00708893275255242 4767 X1428
SGTC_2259 7964009 200 µM -2.45306184927291 0.0188185441727197 no 3268 0.00708229908962441 4762 313134
SGTC_297 0986-0032 24 µM -2.46284357125013 0.0184577953320069 no 3269 0.00689200197311772 4751 2847425
SGTC_3022 9087993 49.47 µM -2.46850187449655 0.0182518189752293 no 3270 0.0067839970725981 4791 17173644
SGTC_1229 0139-0193 12.2 µM -2.46869590826732 0.0182447905349617 no 3271 0.00678032004961944 4781 3090752
SGTC_1833 st055984 71 µM -2.47130123406347 0.0181506415787053 no 3272 0.0067311182868884 4773 676288
SGTC_854 0422-0053 192 µM -2.49218290738161 0.017410890658198 no 3273 0.00634803189857951 4770 3596728
SGTC_923 1900-2434 73.3 µM -2.52291633673103 0.0163690422907432 no 3274 0.00581930436188362 4735 5910570
SGTC_2974 9094440 9.66 µM -2.52300200521813 0.0163662144702115 no 3275 0.00581788687567751 4726 25236134
SGTC_381 3461-2219 42.7 µM -2.54626382771539 0.0156136862520589 no 3276 0.00544414307959367 4749 2883159
SGTC_1392 3455-1037 33.9 µM -2.54893459358557 0.0155292166536423 no 3277 0.00540262816366968 4766 981132
SGTC_2551 apiole 73.87 µM -2.56707078819983 0.0149659242084041 no 3278 0.00512808363195002 4747 10659 A possible DNA adduct former.
SGTC_1916 st067606 49.2 µM -2.57331583271321 0.0147760678401424 no 3279 0.00503646200917747 4701 19590279
SGTC_2294 7971431 200 µM -2.57505764537165 0.0147234856658804 no 3280 0.00501116907432232 4754 5741572
SGTC_1640 st009078 66.4 µM -2.57653672065579 0.0146789615102689 no 3281 0.00498978024524765 4779 690618
SGTC_346 4513-0042 7.16 µM -2.58059829163031 0.014557292588081 no 3282 0.0049314637334171 4743 2827372
SGTC_1277 0873-0036 22 µM -2.58163544325977 0.0145263630133017 no 3283 0.00491666986208617 4791 5965735
SGTC_570 0987-0065 62.6 µM -2.58398500475868 0.0144565043456963 no 3284 0.00488330202621601 4736 3104428
SGTC_2124 5246320 200 µM -2.59309436164259 0.0141883866588435 no 3285 0.00475583346903782 4769 579342
SGTC_2122 5258151 111.688 µM -2.59792977456976 0.0140478134646859 no 3286 0.00468938362648734 4765 2173356
SGTC_305 1682-2595 20.8 µM -2.6234056614258 0.0133268469706454 no 3287 0.00435277751844939 4767 226033
SGTC_1374 2889-5571 141 µM -2.62359617807796 0.0133215780594783 no 3288 0.00435034379457886 4761 2853281
SGTC_2019 4016004 108 µM -2.62401194954479 0.0133100857690725 no 3289 0.00434503681223293 4750 45595336
SGTC_1072 oxiconazole 14.9 nM -2.63610034594858 0.0129796754197639 no 3290 0.00419324633649202 4744 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_292 k038-0015 474 µM -2.64558488798814 0.0127254235658896 no 3291 0.0040774911391662 4776 46368540
SGTC_2723 salbutamol 83.58 µM -2.66244611444924 0.0122840557060927 no 3292 0.00387874945914495 4779 9884233 β2-adrenoceptor agonist
SGTC_2568 diosmetin 100 µM -2.67015349105281 0.0120867610304755 no 3293 0.00379082901001904 4772 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2895 9054447 58.44 µM -2.67632454627528 0.0119307794393173 no 3294 0.00372172637104035 4777 2697450
SGTC_1393 3470-5649 58.2 µM -2.71344057091142 0.0110289627836738 no 3295 0.00332942554483455 4775 4108395
SGTC_327 1273-0057 3.96 µM -2.71631781689105 0.0109615976521143 no 3296 0.00330062575746635 4754 3108138
SGTC_2244 6635614 200 µM -2.73027588911557 0.0106398534174743 no 3297 0.00316406714037813 4766 836499
SGTC_1914 st062367 72.6 µM -2.76141775264954 0.00995151507854398 no 3298 0.00287755050284902 4770 978205
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.77756381646776 0.00961018220044084 no 3299 0.00273840420434981 4777 23665772 A membrane-active detergent.
SGTC_1768 st044301 37.178 µM -2.7957360319392 0.00923829582430538 no 3300 0.00258908374404925 4787 3931349
SGTC_1829 berberine 14.4 µM -2.80209254165683 0.00911121874146639 no 3301 0.00253861535914508 4741 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3081 9117243 49.47 µM -2.80441659426109 0.00906514065522599 no 3302 0.00252038637839045 4753 45595589
SGTC_3108 9121785 49.47 µM -2.80557095819792 0.00904232947897613 no 3303 0.00251137604950696 4740 17140271
SGTC_3089 9117425 49.47 µM -2.81193905625324 0.00891739206611558 no 3304 0.00246219163045244 4773 9401657
SGTC_2645 abamectin 100 µM -2.83004142497759 0.00857046124070397 no 3305 0.00232709888090724 4779 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3196 9111891 49.47 µM -2.83899879289886 0.00840321537890982 no 3306 0.002262766405553 4759 18891510
SGTC_2724 maprotiline 69.64 µM -2.84097266776353 0.00836674812100592 no 3307 0.00224880834769412 4768 4011 A tricyclic antidepressant.
SGTC_193 1273-0060 1.558 µM -2.87144559328854 0.00782113612550858 no 3308 0.00204299555716867 4751 2847393 YHR072W ERG7
SGTC_2100 5377183 190 µM -2.89914630950726 0.00735257781695222 no 3309 0.00187090121558424 4796 2844202
SGTC_1282 0886-0010 32.4 µM -2.90316386709222 0.00728671676176959 no 3310 0.00184706644501995 4791 2836211 YNL267W PIK1
SGTC_1476 4112-3294 3.34 µM -2.92273903762922 0.00697320095762725 no 3311 0.00173483590783285 4779 704369
SGTC_2655 perillic acid 100 µM -2.94207097415583 0.00667532886371855 no 3312 0.001630125975062 4803 5702197 An apoptosis inducer.
SGTC_73 0327-0325 16.231 µM -2.98101903948186 0.00610915982652273 no 3313 0.00143645465320032 4698 53298
SGTC_861 0443-0273 110 µM -3.04623983585483 0.00525588832373531 no 3314 0.00115861458777939 4787 6149169
SGTC_2778 tioconazole 65.09 nM -3.06033328788897 0.00508607757813623 no 3315 0.00110545404189985 4730 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2980 9014342 25.29 µM -3.06090951500305 0.00507923980668462 no 3316 0.00110332885069024 4775 2996599
SGTC_1214 0358-0031 63.7 µM -3.06838927868816 0.00499122131299008 no 3317 0.00107608032151674 4779 4301366
SGTC_2849 9019321 12.99 µM -3.07295814449513 0.00493812777185856 no 3318 0.00105974106565674 4787 16489627
SGTC_1758 st042942 75.2445 µM -3.1025709647563 0.00460604056703699 no 3319 0.000959237726501434 4791 669317
SGTC_2245 6637752 200 µM -3.11689159403991 0.00445271270754449 no 3320 0.000913843831586682 4788 681890
SGTC_216 k038-0035 28.382 µM -3.12505353128501 0.00436737911907839 no 3321 0.000888863527283661 4792 4444231 YPR107C YTH1
SGTC_3059 1327-0034 3 µM -3.13316237645261 0.00428405078150961 no 3322 0.000864668720854665 4749 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_738 1315-0003 72.4 µM -3.13722543245393 0.00424283482387183 no 3323 0.000852774676386294 4799 6251474
SGTC_1656 st012921 11 µM -3.1481612044416 0.00413365750457271 no 3324 0.000821505289034393 4776 6732821
SGTC_2888 9058547 12.99 µM -3.16382516362813 0.0039816545500489 no 3325 0.000778551522592755 4779 16476514
SGTC_3192 9110362 49.47 µM -3.168947938665 0.00393304061520985 no 3326 0.000764958983974108 4791 16649480
SGTC_852 0418-0143 439 µM -3.18193562795984 0.00381216479446087 no 3327 0.000731471650647635 4793 5369229
SGTC_341 1486-1430 230 µM -3.19751290204689 0.00367158712863696 no 3328 0.000693091050813447 4782 2054753 YPL210C SRP72
SGTC_217 ketoconazole 989 nM -3.22653707089332 0.00342200754559892 no 3329 0.000626489998647537 4724 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2580 diallyl disulphide 81.36 µM -3.27063878150817 0.00307188450294029 no 3330 0.000536524381786632 4787 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_735 3076-0345 636 µM -3.33696103509076 0.00260586909301331 no 3331 0.000423499109075899 4803 2888990
SGTC_2371 9071574 200 µM -3.3377542665893 0.00260070466046715 no 3332 0.000422292035625024 4801 45596039
SGTC_1347 1493-0251 600 nM -3.38871833337181 0.0022876585510904 no 3333 0.000351100504173737 4803 3986378
SGTC_539 4859-0462 2.54 µM -3.40424376073544 0.00219931618879758 no 3334 0.000331737582903801 4796 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1387 3342-1166 1.8 µM -3.4100792931899 0.00216691867173162 no 3335 0.000324719974502664 4799 3418228
SGTC_2069 5228469 200 µM -3.49838654205441 0.00172670813298162 no 3336 0.000234041098408926 4793 2835210
SGTC_760 0568-0725 82.9 µM -3.58302218882651 0.0013828296075806 no 3337 0.000169820872276275 4800 3916171
SGTC_513 4245-1575 41.7 µM -3.64020895195809 0.00118721359170217 no 3338 0.000136208440270083 4752 719745
SGTC_769 0302-0231 76 µM -3.64592553805485 0.00116912188337003 no 3339 0.000133215561358581 4784 571869 YER009W NTF2
SGTC_2483 5729050 27.16 µM -3.65467648434201 0.00114191569720289 no 3340 0.000128753239724595 4801 2865180
SGTC_2892 9047358 58.44 µM -3.67022464454798 0.00109500369098346 no 3341 0.000121168699249185 4806 6466771
SGTC_2349 9023730 187.07 µM -3.72346761539052 0.00094742267711056 yes 3342 9.82525385500996e-05 4802 4126287
SGTC_2581 avocatin a 64 µM -3.72977877402852 0.000931196836427944 yes 3343 9.58239816913746e-05 4791 6710728 A skin care supplement.
SGTC_2913 7966556 36.57 µM -3.75823839702297 0.000861151292821809 yes 3344 8.55569063432707e-05 4795 2976516
SGTC_2066 5222451 176 µM -3.7868244911411 0.000795701699099394 yes 3345 7.62923974868435e-05 4796 2281147
SGTC_2722 naftopidil 47.16 µM -3.87290918325731 0.000625259628684289 yes 3346 5.37719546765738e-05 4796 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1353 1498-1206 8.11 µM -3.98518125426189 0.00045348370667955 yes 3347 3.37143177424411e-05 4807 6756808
SGTC_57 miconazole 162.5 nM -4.36005424254801 0.000146686446922821 yes 3348 6.50151038076286e-06 4776 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2487 5918373 44.05 µM -4.43366720213291 0.000116334823117274 yes 3349 4.63217985382264e-06 4805 2876279
SGTC_842 0271-0008 11.1 µM -4.49634877238586 9.52425814790444e-05 yes 3350 3.45651535199591e-06 4810 1221709
SGTC_2894 9048625 32.47 µM -4.88443073816134 2.61418321993036e-05 yes 3351 5.18640479380592e-07 4809 4092861
SGTC_2342 7990637 118.86 µM -4.89903953451968 2.48544200176794e-05 yes 3352 4.81531334810802e-07 4809 2033102 YER133W GLC7
SGTC_310 1273-0058 1.06 µM -5.19179306022386 8.78366680125182e-06 yes 3353 1.04139213946826e-07 4717 2734232
SGTC_3143 9086658 49.47 µM -5.44589700238783 3.40939847909953e-06 yes 3354 2.57724791313189e-08 4805 25236626
SGTC_1787 fluconazole 80 µM -6.08074529249349 2.68348101300969e-07 yes 3355 5.98125966394216e-10 4774 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_453 enantio-paf c16 10 µM -6.35950843833639 8.10931160557344e-08 yes 3356 1.01200206201382e-10 4731 13871343 A lipid and platelet activating factor