SGTCid condition conc unit BIO3|YNR058W.score BIO3|YNR058W.strain.pval BIO3|YNR058W.strain.significant BIO3|YNR058W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2442 5158906 48.48 µM 15.4558703309168 6.55906300577736e-52 yes 1 3.44374848759411e-54 1 1893835
SGTC_2461 5755302 26.15 µM 6.595605893295 6.00405720506421e-11 yes 2 2.11761306172765e-11 10 2788904
SGTC_1064 honokiol 6.76 µM 6.53869835053641 8.65345530961188e-11 yes 3 3.102827215795e-11 2 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2164 5685496 200 µM 6.03563332517167 1.91946402619761e-09 yes 4 7.91702161620551e-10 4 759046
SGTC_1746 st038117 42 µM 5.62667187685159 2.00291931035867e-08 yes 5 9.18598603467652e-09 9 2898218
SGTC_337 1315-0038 354 µM 5.43760891018041 5.61847869153479e-08 yes 6 2.70001712863289e-08 11 1626437
SGTC_1814 st052110 31.539 µM 4.98936676516038 5.67557734290429e-07 yes 7 3.02887689593386e-07 6 674163
SGTC_115 0527-0192 112.043 µM 4.67548288724858 2.56583393960261e-06 yes 8 1.46631366283497e-06 42 4233931
SGTC_1726 st035556 14.5795 µM 4.66570325301488 2.68539668311418e-06 yes 9 1.53781650790869e-06 22 5919439
SGTC_481 bay k-8644 50 µM 4.54516325335749 4.67373970807992e-06 yes 10 2.74463459031192e-06 16 2303 A calcium channel antagonist.
SGTC_2135 5326629 150.42 µM 4.53084748671524 4.98723299145894e-06 yes 11 2.93737696547798e-06 13 5020077
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 4.489132436035 6.01937137729529e-06 yes 12 3.57569142166655e-06 15 3256 An antibiotic and ribosome inhibitor.
SGTC_1248 0469-0687 58.6 µM 4.18904587393935 2.22208795340814e-05 yes 13 1.40064886386925e-05 20 4017482
SGTC_68 0986-0284 82.829 µM 4.18832465045766 2.22885225781592e-05 yes 14 1.40510659066247e-05 59 423278 YIL048W NEO1
SGTC_3124 9127567 49.47 µM 4.14739028612973 2.64644950342533e-05 yes 15 1.68143264759561e-05 13 17592030
SGTC_2131 toluylene red 5.2905 µM 4.11061080710849 3.08395565276906e-05 yes 16 1.97306926442678e-05 20 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3049 9092223 49.47 µM 4.0559562540811 3.86236665639167e-05 yes 17 2.49648022886739e-05 21 8623917
SGTC_1757 st041620 31.8375 µM 4.0191566495597 4.48744785418265e-05 yes 18 2.92034148877674e-05 30 5289815
SGTC_693 4161-2696 114 µM 4.01442765948837 4.57437933914057e-05 yes 19 2.97951080450091e-05 9 805759
SGTC_2907 7721985 69.9 µM 4.01026905452769 4.65213773027543e-05 yes 20 3.03247985630754e-05 19 3267881
SGTC_3134 9127454 49.47 µM 3.92956143259344 6.43229649356294e-05 yes 21 4.25504667731436e-05 13 24262820
SGTC_1785 bathophenanthroline 24 µM 3.92928701261025 6.43932148489208e-05 yes 22 4.25990505248878e-05 48 72812 An iron chelator.
SGTC_2173 5763948 167 µM 3.8907223378715 7.50176414209772e-05 yes 23 4.99731245947613e-05 12 2867177
SGTC_2451 5856223 45.7 µM 3.8826576235072 7.74388200525844e-05 yes 24 5.16604990846174e-05 24 2179896
SGTC_497 capsazepine 133 µM 3.81939328331992 9.91484824245988e-05 yes 25 6.68901606313865e-05 12 2733484 A calcium channel blocker.
SGTC_2541 muurolladie-3-one 83.07 µM 3.81764285621076 9.982359112278e-05 yes 26 6.73663870709934e-05 33 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_438 sphingosine 6.67 µM 3.78247861946969 0.000114335642038082 yes 27 7.76372170987439e-05 27 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1680 diphenhydramine 100 µM 3.76735442274174 0.000121167315978076 yes 28 8.24933457577818e-05 34 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2151 5563267 85.4165 µM 3.67336639439151 0.000172978720253889 yes 29 0.000119687931606729 28 5310824
SGTC_1125 tnp00248 1.32998 µM 3.66667839231389 0.000177362463280851 yes 30 0.00012286075860198 39 24207736
SGTC_2744 captopril 92.04 µM 3.66328388774676 0.000179626982226211 yes 31 0.000124501153749407 15 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2718 lomofungin 53.02 µM 3.6417779548672 0.000194614012124707 yes 32 0.000135380784818952 16 5351222 A RNA synthesis inhibitor.
SGTC_1195 1502-0147 41.1 µM 3.63842376134986 0.000197054214156528 yes 33 0.000137155902498448 34 817940
SGTC_172 1112-0046 2.638 µM 3.62489432451814 0.000207190145849114 yes 34 0.000144539816294144 44 2802135 YIL048W NEO1
SGTC_474 dl-dihydrosphingosine 5 µM 3.62237092610835 0.000209133685709064 yes 35 0.000145957564483707 35 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_891 0929-0073 133 µM 3.56159692797511 0.000261413228793069 yes 36 0.000184302988675355 36 5603632
SGTC_161 4065-0411 162.148 µM 3.55205946403872 0.000270647096561667 yes 37 0.000191114234960646 82 1906281 YLR208W SEC13
SGTC_3182 9108849 49.47 µM 3.52997874419641 0.000293203630266192 yes 38 0.000207796527227832 21 17133045
SGTC_948 3448-0295 75.3 µM 3.52682040683046 0.000296569512101754 yes 39 0.00021029097023692 44 678569
SGTC_3125 9127534 49.47 µM 3.45090283486051 0.000389141003980933 yes 40 0.000279357338772061 22 1639235
SGTC_2827 7993847 71.43 µM 3.44914434170984 0.000391573296257115 yes 41 0.0002811830033054 38 2985692
SGTC_1025 k007-0731 70 µM 3.44783027564134 0.000393400075504856 yes 42 0.000282554511998329 27 6256118
SGTC_1417 3966-0327 90.4 µM 3.42387024207585 0.000428127114734143 yes 43 0.000308680456343076 30 651118
SGTC_2717 st081029 62.2815 µM 3.37631342848636 0.000505624096806041 yes 44 0.000367320889412254 30 5292846
SGTC_1545 lovastatin 49.4 µM 3.35921523090837 0.00053652494958872 yes 45 0.000390820820281939 54 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2844 9010103 25.97 µM 3.32099513663009 0.000612018313445842 yes 46 0.000448485501655767 53 2480525
SGTC_3044 9093193 49.47 µM 3.30607825741168 0.000644057264127625 yes 47 0.000473058297007813 52 25236277
SGTC_595 3909-8003 73.7 µM 3.2964480611124 0.000665556240202733 yes 48 0.000489578587972338 34 699517
SGTC_3055 9094636 49.47 µM 3.26720820907587 0.000734956233010886 yes 49 0.000543068837423276 28 25236176
SGTC_2970 9090938 41.86 µM 3.26046397908615 0.000751882498836965 yes 50 0.000556150472416889 85 17217104
SGTC_904 1141-0088 396 µM 3.24296450033229 0.000797490408629052 yes 51 0.000591464746384003 38 1378119
SGTC_125 0133-0007 11.75 µM 3.19577073763032 0.000933481463270509 yes 52 0.000697289380309726 33 26541
SGTC_743 1275-0778 158 µM 3.19133846105237 0.000947290731780152 yes 53 0.000708076384978031 74 2849257 YMR203W TOM40
SGTC_2448 5185112 27.17 µM 3.16926027255808 0.00101891492561456 no 54 0.000764137363028339 30 5718189
SGTC_391 gliotoxin 8.33 µM 3.10922704218077 0.00123952343557682 no 55 0.000937887577194253 92 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1732 st034308 51.822 µM 3.10839341512806 0.00124287328038603 no 56 0.000940537412057066 66 830119
SGTC_2947 9072639 7.68 µM 3.09548754994791 0.00129580194391973 no 57 0.000982448108379384 94 16488146
SGTC_1524 corynanthine 62.1 µM 3.09281138696683 0.0013070319903409 no 58 0.000991350526002061 61 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_459 nigericin 15.3 µM 3.08277267763964 0.00134995508681274 no 59 0.00102540874272617 106 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_574 1315-0397 40 µM 3.06598139190451 0.00142463855712044 no 60 0.00108478408351636 93 6794277
SGTC_322 k048-0136 19.3 µM 3.02046026904451 0.00164647107604255 no 61 0.00126195409472262 45 6823282
SGTC_389 tpck 16.7 µM 2.98200088101148 0.0018579330355999 no 62 0.00143185587397554 74 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.9293052275411 0.00218778571514096 no 63 0.00169860323371153 62 688669
SGTC_906 1165-0455 526 µM 2.91672737609012 0.00227398491927118 no 64 0.00176862399366049 44 3252859
SGTC_252 miconazole 1.30953 nM 2.88420736830401 0.00251129340647694 no 65 0.00196200132789091 91 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2496 diffractaic acid 79.83 µM 2.88215945869998 0.00252696162026307 no 66 0.0019747990128661 73 94870 An apoptosis inducer which activates caspases.
SGTC_3103 9120822 49.47 µM 2.80126655670959 0.00322113360717335 no 67 0.00254512272057022 65 17141819
SGTC_3131 9127911 49.47 µM 2.79169396776329 0.00331372621633813 no 68 0.00262164604231405 85 45595681
SGTC_1017 4239-0030 168 µM 2.78335878088615 0.00339629147709793 no 69 0.00268996386210776 106 1149593
SGTC_3016 9080866 49.47 µM 2.77291323726407 0.00350236891668437 no 70 0.00277784655452497 91 17066299
SGTC_1352 1496-0991 99 µM 2.76512600476127 0.00358337638944312 no 71 0.0028450405772213 78 3000039
SGTC_2825 7998094 58.44 µM 2.750343821465 0.00374178966894038 no 72 0.0029766381507653 94 2987815
SGTC_2560 caryophyllene 100 µM 2.72224149077651 0.00406036306329577 no 73 0.00324203704709299 85 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1647 st011722 22.4 µM 2.71930703765131 0.0040949903559389 no 74 0.00327094260384454 60 2854783
SGTC_3222 9128301 49.47 µM 2.71677483848081 0.00412508312297321 no 75 0.00329607187490531 89 4911358
SGTC_2774 tamoxifen 10.92 µM 2.70039068890651 0.00432462090560058 no 76 0.0034629046061107 78 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2276 7947513 42.08 µM 2.69770477138136 0.00435814256712188 no 77 0.00349096647574465 90 2105100
SGTC_2823 7987624 58.44 µM 2.66835130989033 0.0047399112026051 no 78 0.0038112254642633 132 2239440
SGTC_1357 1503-1303 39.5 µM 2.63903428435437 0.00515069866273071 no 79 0.00415712860587699 128 292895
SGTC_1607 st000305 50.6 µM 2.63524791846789 0.00520600010958838 no 80 0.00420379248497066 79 5457690
SGTC_2397 5161689 200 µM 2.6259880350025 0.00534347649687021 no 81 0.00431989271740934 122 2259942
SGTC_1898 st060199 18.6 µM 2.62415255591633 0.00537110707780684 no 82 0.00434324339667929 72 688866
SGTC_1696 st025591 34.7925 µM 2.61799842507342 0.00546467819570708 no 83 0.00442236066679746 114 2787147
SGTC_1611 st001856 99.4 µM 2.60406258623932 0.00568194056402221 no 84 0.00460629660303934 92 647478
SGTC_2953 9074162 66.49 µM 2.59387325999837 0.00584561313667097 no 85 0.00474507317339969 90 16451992
SGTC_2362 9071156 126 µM 2.5856630889432 0.00598052302262886 no 86 0.00485959402696966 89 653133
SGTC_178 4092-0806 87.505 µM 2.58296765972767 0.00602541245919985 no 87 0.00489772523072554 223 2169044
SGTC_89 0302-0250 142.109 µM 2.5802592628269 0.00607081842105646 no 88 0.00493630821493761 103 4203518 YLR208W SEC13
SGTC_1937 st074714 47.2 µM 2.57819516293662 0.00610562616198862 no 89 0.00496589433942978 119 17250970
SGTC_879 0831-1030 162 µM 2.57403917454951 0.00617624715513312 no 90 0.00502594456155849 164 1549252
SGTC_2831 7999036 19.48 µM 2.56313093616023 0.00636505965150308 no 91 0.00518664600002046 158 2988270
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.54306665225336 0.00672573316639245 no 92 0.00549421329046719 143 23665772 A membrane-active detergent.
SGTC_2157 5649910 96.377 µM 2.5336607848708 0.00690094475107108 no 93 0.00564389712672035 117 2858091
SGTC_1168 k815-0004 80.5 µM 2.52735251021959 0.00702070124797701 no 94 0.00574630421860249 92 642433
SGTC_2551 apiole 73.87 µM 2.52267736965734 0.00711063399980157 no 95 0.00582325997366085 53 10659 A possible DNA adduct former.
SGTC_1513 0337-0559 19 µM 2.51426442371169 0.00727503128517309 no 96 0.00596404813747524 126 775073
SGTC_1565 sinapyl alcohol 95.1 µM 2.51193204238201 0.00732119764264973 no 97 0.00600361042628541 132 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2977 9011197 71.43 µM 2.50595230416728 0.00744074033282609 no 98 0.00610610460563881 81 2704722
SGTC_250 brefeldin a 552.239 µM 2.50463728480511 0.00746725880913074 no 99 0.00612885124722545 77 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_272 doxorubicin 8.13 µM 2.49108416412625 0.00774545764366523 no 100 0.0063676973861823 147 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1773 st048542 73.5835 µM 2.48151358498775 0.00794736464600656 no 101 0.00654128617061694 148 3237138
SGTC_354 2783-3500 4.88 µM 2.46519114821884 0.00830240467679589 no 102 0.00684700879617097 157 6740761
SGTC_2587 piperic acid 92.2 µM 2.45519001819461 0.00852676255929169 no 103 0.00704050676951771 121 5370536
SGTC_1051 3253-3903 78 µM 2.44508672156926 0.00875879653587511 no 104 0.00724086577371304 143 5509239
SGTC_254 nsc-64875 3.808 µM 2.44474089491986 0.00876683589507448 no 105 0.00724781199188079 118 56993
SGTC_3319 9138450 16.7555 µM 2.43440888928576 0.00901002425993037 no 106 0.00745806726169305 116 2029690
SGTC_296 1222-0039 74.9 µM 2.42915853620527 0.00913585299763542 no 107 0.0075669565545719 108 5984176
SGTC_2630 antimycin a 100 µM 2.40444013709033 0.00974913982791948 no 108 0.00809862939210339 155 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1421 4029-0249 71.4 µM 2.40206494719005 0.00980992259165386 no 109 0.00815140683439001 123 2894095
SGTC_210 3551-0445 56.827 µM 2.39686469212941 0.00994415751137717 no 110 0.00826801438990995 162 2865180 YOR207C RET1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.39327872844278 0.0100376541034112 no 111 0.00834927507192359 136 5377381
SGTC_2952 9073731 13.78 µM 2.37695060475236 0.0104731411817481 no 112 0.00872821278450437 186 16457353
SGTC_921 1561-0023 372 µM 2.36423792560602 0.0108235128013755 no 113 0.00903360262381181 139 24050882
SGTC_3014 9081533 49.47 µM 2.34328525821916 0.0114232671047763 no 114 0.00955738115094499 104 21367265
SGTC_1164 k060-0068 93.7 µM 2.34307007542827 0.011429573406892 no 115 0.00956289525147063 162 5963676
SGTC_1872 amphotericin b 148 nM 2.32814866855839 0.0118743121076841 no 116 0.00995210538623999 144 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_645 0845-0943 5.41 µM 2.32700704139979 0.0119089488374399 no 117 0.00998244524221947 122 1885106
SGTC_3298 9116858 71.43 µM 2.32160345752039 0.0120740841232033 no 118 0.0101271487782395 127 2506942
SGTC_282 k297-0036 65.7 µM 2.30862599323999 0.0124788104644269 no 119 0.0104821721344174 90 5061378
SGTC_317 4495-0002 170 µM 2.30696017879947 0.0125316033070601 no 120 0.0105285200787153 127 15991618
SGTC_2228 7354201 200 µM 2.3048923373633 0.0125974060602741 no 121 0.0105863019360727 69 753451
SGTC_869 0564-0080 44.1 µM 2.29825573459324 0.0128106200100249 no 122 0.0107736191127464 161 6843321
SGTC_3086 9117350 49.47 µM 2.2767000230063 0.0135248139330928 no 123 0.011402072577405 67 2679265
SGTC_3300 9124615 50.48 µM 2.27346970791284 0.013634750214067 no 124 0.0114989447860788 172 24824903
SGTC_2053 5265679 138 µM 2.27285498641973 0.0136557579392879 no 125 0.0115174600841406 186 764595
SGTC_1982 st072467 71.9 µM 2.2725318262106 0.0136668129348335 no 126 0.011527203989801 203 3163533
SGTC_1629 st005085 44.9 µM 2.27232508163308 0.013673889514827 no 127 0.0115334414934212 191 24207091
SGTC_2802 7925815 54.55 µM 2.27170044951555 0.0136952890139888 no 128 0.0115523045134933 191 1262923
SGTC_316 k060-0003 58.6 µM 2.25615255779412 0.0142373382617079 no 129 0.0120305392721888 142 6152314
SGTC_3226 9131256 49.47 µM 2.25451074038192 0.0142956417447679 no 130 0.0120820278806099 38 17178073
SGTC_2232 chlorophetanol 41.5365 µM 2.25191005655628 0.0143884168997428 no 131 0.0121639782461042 300 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_668 1682-0499 62.6 µM 2.24982219691633 0.0144632726001356 no 132 0.0122301171919789 175 682214
SGTC_3352 9151559 45.5865 µM 2.24316776792256 0.0147040939424249 no 133 0.0124429989758388 143 17159339
SGTC_545 4218-0007 221 µM 2.23985227828383 0.0148253623878025 no 134 0.0125502573155038 168 2840508
SGTC_692 k241-0027 77.8 µM 2.2357984108001 0.014974805848631 no 135 0.0126824895479536 139 3600480
SGTC_2785 7756463 72.73 µM 2.22996761016148 0.0151920247094335 no 136 0.0128747966231605 157 2201551
SGTC_2876 9059903 25.97 µM 2.22570570167305 0.0153525039222978 no 137 0.0130169503029587 138 6916095
SGTC_2603 homopterocarpin 100 µM 2.20799887177834 0.0160349229079205 no 138 0.0136221759060323 220 101795 A weak amylase inhibitor.
SGTC_3028 9087778 49.47 µM 2.20256996400388 0.0162492923402812 no 139 0.0138125364312542 146 17217395
SGTC_80 0159-0065 512.242 µM 2.20037803692457 0.0163365373396375 no 140 0.0138900423830086 85 1548079
SGTC_2811 7967822 32.47 µM 2.1878705533554 0.0168420839248551 no 141 0.0143395163993394 162 2232244
SGTC_499 genistein 192 µM 2.18358848259299 0.0170182104037928 no 142 0.0144962503183879 79 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2611 pyromycin 23.93 µM 2.18135723011749 0.0171106066911234 no 143 0.0145785022371714 195 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2035 5154463 94.595 µM 2.17822161574277 0.0172411770143286 no 144 0.0146947707690963 198 2769623
SGTC_3173 9105693 49.47 µM 2.17068793238708 0.017558371454792 no 145 0.0149773850095814 201 17096658
SGTC_3052 9092717 49.47 µM 2.15096335902167 0.0184125296389913 no 146 0.0157395459380724 200 25237534
SGTC_341 1486-1430 230 µM 2.1482709963048 0.0185318215959998 no 147 0.0158461167831147 197 2054753 YPL210C SRP72
SGTC_2809 7964133 12.99 µM 2.14012002619096 0.0188969905701856 no 148 0.0161725340302125 234 1253665
SGTC_899 1083-0020 478 µM 2.13911418650452 0.0189424743409958 no 149 0.0162132108713746 188 767123
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.13570279887881 0.0190974303680131 no 150 0.0163518230678732 244 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1614 st002383 48.6 µM 2.13510512059074 0.0191246894657172 no 151 0.0163762122362201 174 1947235
SGTC_336 4111-0029 111 µM 2.12922582402473 0.0193946019043706 no 152 0.0166177906646001 147 3131175
SGTC_2309 7664088 163.95 µM 2.12840307066857 0.0194326305929043 no 153 0.0166518393886076 232 704922
SGTC_907 3448-6986 75.5 µM 2.12034466095169 0.0198084605800717 no 154 0.016988494945572 216 590582
SGTC_3009 9080819 71.4286 µM 2.11271457311484 0.0201699826158846 no 155 0.0173126026021611 188 17027216
SGTC_793 0488-0545 106 µM 2.09231595924201 0.0211640686838858 no 156 0.0182051305052818 196 292548
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.0919912172997 0.0211802236273236 no 157 0.0182196506794803 135 616764
SGTC_941 3237-0776 460 µM 2.08809139660121 0.021375044240526 no 158 0.0183947954908313 180 760008
SGTC_2196 6573537 42.6665 µM 2.08394900524617 0.0215836400649861 no 159 0.0185824030342219 149 2903087
SGTC_578 3460-0051 92 µM 2.08209684813908 0.0216774630600722 no 160 0.0186668121945282 209 2876744
SGTC_707 0865-0008 204 µM 2.07974958416497 0.0217968610692561 no 161 0.0187742537659417 156 723043
SGTC_2543 pimpinellin 60.67 µM 2.07567323696364 0.0220055321076634 no 162 0.0189620914078927 199 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1065 prochlorperazine maleate 2.48 µM 2.07448531936233 0.0220666588580296 no 163 0.0190171303951974 206 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_557 1315-0110 16.2 µM 2.06193722623194 0.0227211454344272 no 164 0.0196068563971996 209 6833801
SGTC_2235 salicylic acid 500 µM 2.06147193944141 0.022745725236947 no 165 0.0196290189171585 131 338 A COX inhibitor and kinase inhibitor.
SGTC_3321 9137793 26.8275 µM 2.05506021958388 0.0230867268194139 no 166 0.0199365943004069 262 4904192
SGTC_38 0929-0051 58.268 µM 2.05211754268153 0.0232446658887831 no 167 0.0200791202290158 230 1379719
SGTC_1358 1509-0022 2.48 µM 2.04670955918413 0.0235372945696206 no 168 0.020343305061504 196 3258434
SGTC_2279 7948423 32.93 µM 2.04580921032828 0.0235863125459816 no 169 0.0203875727550389 158 1247112
SGTC_2761 levamisole 97.89 µM 2.0399476888392 0.0239075366130495 no 170 0.0206777681054725 181 26879 An alkaline phosphatase inhibitor.
SGTC_1041 0206-0046 107 µM 2.03768431676875 0.024032554489783 no 171 0.0207907568085312 201 50494
SGTC_2705 st078069 42.8 µM 2.03231242413665 0.0243314726235548 no 172 0.0210610187468757 185 1530061
SGTC_3154 9100113 49.47 µM 2.02646790648978 0.0246602295305922 no 173 0.0213584291548712 219 25237525
SGTC_1497 4476-2978 41.3 µM 2.02591104220728 0.0246917469726904 no 174 0.0213869507397897 253 1528379
SGTC_3088 9117578 49.47 µM 2.02185415113064 0.0249223805788853 no 175 0.0215957107722017 178 678341
SGTC_1777 st045864 34.765 µM 2.01685556397404 0.0252090308275675 no 176 0.0218552942228734 197 4691462
SGTC_66 0109-0187 42.4 µM 2.01664211516666 0.0252213325715417 no 177 0.0218664373238229 231 759417
SGTC_1985 st071382 65.5 µM 2.00948777089181 0.0256365798153729 no 178 0.0222427151561565 198 6123237
SGTC_2868 9035608 32.47 µM 2.00777331772574 0.0257369345525259 no 179 0.0223336927233561 209 6462614
SGTC_2643 anethole 100 µM 2.00734469298426 0.0257620752203985 no 180 0.0223564867090921 231 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1424 4048-1941 275 µM 2.00082297186071 0.0261471443596868 no 181 0.0227057354541082 240 X1424
SGTC_715 0868-0130 184 µM 1.99547846419578 0.0264662835397455 no 182 0.0229953603404625 179 2876258
SGTC_3179 9107801 49.47 µM 1.99443741306363 0.0265288255896779 no 183 0.0230521366525835 199 4818259
SGTC_1235 benzylparaben 21.5 µM 1.99080610435183 0.0267479469553637 no 184 0.0232511040046348 204 7180
SGTC_754 3474-0146 171 µM 1.99066464580993 0.026756513378695 no 185 0.0232588839902291 234 24762078
SGTC_1856 st057054 55.7 µM 1.97491941298607 0.027724432888293 no 186 0.0241386469892715 231 1266018
SGTC_3138 9097216 49.47 µM 1.9717728924909 0.0279213188054884 no 187 0.0243177690824286 207 25237486
SGTC_2288 7946289 167.31 µM 1.96136678454037 0.0285807682758757 no 188 0.0249181258883822 268 1246052
SGTC_2738 aclarubicin 5.55 µM 1.95833027000811 0.0287756203682399 no 189 0.0250956355491897 145 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1155 4088-0394 48.2 µM 1.95241737666914 0.0291582185078993 no 190 0.0254443358243199 233 2326248
SGTC_792 4534-1957 155 µM 1.9522021432525 0.0291722246785921 no 191 0.0254571049202462 227 1717904
SGTC_969 1313-0238 134 µM 1.94321817924429 0.0297618545980734 no 192 0.0259949012480152 291 5212874
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.94079030133672 0.0299228859708256 no 193 0.0261418589462926 256 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1403 3909-7815 62.9 µM 1.93165553299955 0.0305352458102802 no 194 0.0267010183216499 185 6615483
SGTC_2769 toremifene 3.73 µM 1.93130869889021 0.0305586992831952 no 195 0.0267224441364251 230 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1292 0kpi-0043 232 µM 1.93048320589173 0.0306145804514058 no 196 0.0267734970561571 224 3333905
SGTC_470 aa-861 153 µM 1.92712507092927 0.030842780119194 no 197 0.0269820225009092 294 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2191 5911152 200 µM 1.91613657318322 0.031599357545514 no 198 0.0276738570602339 230 2875902
SGTC_1936 st074407 74.3 µM 1.91131347591469 0.0319362466413133 no 199 0.0279821541514736 308 809813
SGTC_114 0364-0001 490.298 µM 1.91040508981001 0.0320000273885604 no 200 0.0280405380109114 288 4003655
SGTC_1975 st070967 30.8 µM 1.90764994781063 0.0321941184915823 no 201 0.0282182374417222 286 261391
SGTC_2571 chrysanthemic acid 100 µM 1.90405487411774 0.0324488403798473 no 202 0.028451518957578 223 2743 An insecticide.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.90039484878941 0.0327098700067854 no 203 0.028690661207592 344 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_137 0438-0332 85.389 µM 1.89531272727652 0.0330751911442115 no 204 0.0290254915089853 416 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2926 9010726 65.15 µM 1.89480640140662 0.0331117710981553 no 205 0.0290590274118398 266 2994293
SGTC_2453 5731132 22.18 µM 1.8920749635937 0.0333096815349864 no 206 0.0292404967824108 249 1362040
SGTC_2239 6685329 187.64 µM 1.89011425002417 0.033452347802839 no 207 0.02937134084151 273 805680
SGTC_1097 itavastatin 7.23 µM 1.88982811849195 0.0334732094290148 no 208 0.0293904758113909 270 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1512 0259-0544 12.2 µM 1.88849674956861 0.0335704194038033 no 209 0.0294796469351949 282 18476
SGTC_2968 9090663 33.37 µM 1.88521826868135 0.0338107887977942 no 210 0.0297001876738209 276 25236811
SGTC_1792 st045773 43.6 µM 1.87844529511564 0.0343118499666046 no 211 0.0301601370321287 272 2919270
SGTC_3073 9114972 49.47 µM 1.87822464855147 0.034328275384396 no 212 0.030175219794138 220 41905075
SGTC_3317 9138495 8.753 µM 1.87620708419852 0.034478767224431 no 213 0.0303134248490424 266 17020139
SGTC_2507 purpurin 79.67 µM 1.87591842793617 0.0345003425964264 no 214 0.0303332409011106 280 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1096 rimcazole 32.2 µM 1.86835497273921 0.035069631094172 no 215 0.0308563044297717 226 18528119 A dopamine reuptake inhibitor.
SGTC_1897 st060201 15 µM 1.8599625340164 0.0357103144653385 no 216 0.0314454134315229 236 611878
SGTC_263 alizarin 107.927 µM 1.85791903756715 0.0358677597985928 no 217 0.0315902562345012 358 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2116 5511452 16.8835 µM 1.85740616785672 0.0359073640400826 no 218 0.0316266948164898 271 870744
SGTC_1493 4348-0038 111 µM 1.85659104334476 0.0359703823674191 no 219 0.0316846795929317 293 800424
SGTC_507 nimesulide 162 µM 1.85545491572586 0.0360583689634356 no 220 0.0317656458008602 275 4495 A COX2 inhibitor.
SGTC_2285 7945142 200 µM 1.85053453207751 0.0364414614709308 no 221 0.0321182728505764 270 2970608
SGTC_1406 3909-7906 11.9 µM 1.8487542375606 0.0365808900663282 no 222 0.0322466540167914 264 X1406
SGTC_2380 9035439 200 µM 1.84761984754851 0.0366699603285945 no 223 0.0323286782126641 302 6462575
SGTC_575 k072-0246 11.9 µM 1.8474687481403 0.0366818377593105 no 224 0.0323396167211905 265 6796779
SGTC_3177 9107506 49.47 µM 1.84511601522589 0.0368671847028377 no 225 0.0325103319973006 189 8897194
SGTC_2061 5245884 80.95 µM 1.83580130817967 0.0376085232440482 no 226 0.0331935239662107 284 573863
SGTC_1039 k821-0043 94 µM 1.83192606933018 0.037920509781284 no 227 0.0334812179932947 274 15992768
SGTC_1809 st050081 57.6 µM 1.83000014427197 0.0380763453138576 no 228 0.0336249586329542 271 5036894
SGTC_1150 3909-7983 10.9 µM 1.82562927921527 0.0384319507395271 no 229 0.0339530611927926 314 23965914
SGTC_1787 fluconazole 80 µM 1.8245762411102 0.0385180273978482 no 230 0.0340325007329005 375 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_189 3970-0742 2.116 µM 1.82294690186111 0.038651521207498 no 231 0.0341557166736889 216 2891807
SGTC_1311 1190-0148 100 µM 1.82002491429314 0.0388918673771125 no 232 0.0343776054330585 337 1961333
SGTC_1066 ketoconazole 628 nM 1.81057242078352 0.0396777249928414 no 233 0.0351035322705157 310 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2308 7584454 197.62 µM 1.8094983025782 0.039767835880265 no 234 0.0351868118105182 319 893577
SGTC_3264 9137442 49.47 µM 1.80827971609693 0.0398702680056193 no 235 0.0352814885860347 224 17015726
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.80693390451561 0.0399836435423843 no 236 0.0353862926934307 361 688788
SGTC_3114 9122766 49.47 µM 1.80540901658892 0.0401124215144348 no 237 0.035505350626738 267 17176985
SGTC_2243 6634756 200 µM 1.80161030839229 0.0404346910993107 no 238 0.035803369139975 236 885676
SGTC_625 k213-0058 121 µM 1.78971819714202 0.0414571914250789 no 239 0.0367496127568198 471 3655420
SGTC_1059 3448-6867 171 µM 1.78105751422601 0.0422149563310423 no 240 0.0374515277211176 283 3934407
SGTC_1878 temozolomide 1 mM 1.77914246188654 0.0423840175208599 no 241 0.0376082043585225 246 5394 DNA alkylating agent.
SGTC_2412 st077135 33.4 µM 1.77689319931883 0.0425832817806967 no 242 0.0377929067644439 304 13258915
SGTC_1005 4092-0690 4.4 µM 1.77011335134051 0.0431885013221807 no 243 0.0383541299156559 286 1529343
SGTC_602 3130-1533 38.1 µM 1.76818715719888 0.0433617092496158 no 244 0.0385148102471689 337 720941
SGTC_3091 9116372 49.47 µM 1.76751882123765 0.0434219384978881 no 245 0.0385706899040279 276 17169793
SGTC_2139 5578692 56.4705 µM 1.76741971186981 0.0434308758053608 no 246 0.0385789820734763 248 650991 YMR113W FOL3
SGTC_2864 9034755 47.6 µM 1.76724929496425 0.0434462468285559 no 247 0.0385932437170562 287 4930451
SGTC_219 mitoxanthrone 164.414 µM 1.76387756818022 0.0437512690726156 no 248 0.0388762971376504 317 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1966 st070145 16.1 µM 1.75761658837241 0.0443222481493085 no 249 0.0394063844487946 287 3748532
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.7569951139509 0.0443792505454374 no 250 0.0394593210147085 395 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2065 5221596 34.26 µM 1.74657691279316 0.0453436458127406 no 251 0.0403553774269014 292 788581
SGTC_2064 5220758 200 µM 1.74253741271448 0.045722081201294 no 252 0.0407072254147048 356 788518
SGTC_3236 9132701 49.47 µM 1.73729809823631 0.0462166968700083 no 253 0.0411672835357666 298 24282524
SGTC_951 1171-0579 82.7 µM 1.7344752428298 0.0464849634529401 no 254 0.0414168973738332 419 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2208 7283366 200 µM 1.72630438313131 0.0472685210021593 no 255 0.0421463336201588 289 898663
SGTC_1094 duloxetine 25.4 µM 1.72587104429135 0.0473103705244239 no 256 0.0421853075145291 316 60834 A selective serotonin reuptake inhibitor.
SGTC_890 0929-0006 47.2 µM 1.70414717097534 0.0494466781198977 no 257 0.0441767979610089 284 1378169
SGTC_142 0335-0849 62.6745 µM 1.70215017764742 0.0496468649060439 no 258 0.0443636098317389 476 3889043 YPR107C YTH1
SGTC_2950 9072895 21.46 µM 1.70037194511209 0.0498256660484482 no 259 0.0445304927217819 380 17332245
SGTC_1473 k844-0725 134 µM 1.69987690683816 0.0498755334047543 no 260 0.0445770407681721 349 54682906
SGTC_1706 st031321 9.9705 µM 1.69876191769655 0.0499879969089927 no 261 0.0446820258516031 296 6103185
SGTC_1200 1643-0193 18.4 µM 1.69810053309291 0.0500548030370459 no 262 0.044744394499358 326 5403974
SGTC_1671 st016596 74.5 µM 1.69585444411991 0.0502822108950015 no 263 0.0449567244237268 351 2829167
SGTC_1981 st071826 47 µM 1.69233674219625 0.0506400185208587 no 264 0.045290893033187 285 11838600
SGTC_132 0417-1715 25.805 µM 1.69150469273156 0.0507249473886866 no 265 0.0453702261420261 324 6769098
SGTC_2917 7979103 53.79 µM 1.69027104743679 0.0508510766250636 no 266 0.045488055729863 385 2980565
SGTC_2940 9060638 45.86 µM 1.68718846729118 0.0511673345995338 no 267 0.0457835591285248 348 4027022
SGTC_3070 9117005 49.47 µM 1.68453150333268 0.0514411804852748 no 268 0.0460394982077904 241 8779016
SGTC_2589 lobaric acid 100 µM 1.68407134964296 0.0514887254470875 no 269 0.046083940270404 336 73157 A novel microtubule depolymerizer.
SGTC_3234 9132280 49.47 µM 1.68346625157336 0.05155129983903 no 270 0.0461424336367044 344 17612295
SGTC_882 0843-0131 351 µM 1.68033725229857 0.0518758412383808 no 271 0.0464458584880759 348 5425421
SGTC_2423 st077119 87.2 µM 1.67616007996955 0.0523116278967582 no 272 0.0468534205886282 323 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2127 5253358 187.912 µM 1.67564012122183 0.0523660758306509 no 273 0.0469043525367284 315 20612
SGTC_3299 9121982 43.1275 µM 1.66822972952248 0.053146961746273 no 274 0.0476350656721913 353 17594604 YPL160W CDC60
SGTC_3349 9149703 23.001 µM 1.66657701435668 0.0533223730666447 no 275 0.0477992712944126 313 4910494
SGTC_995 3931-2021 34.6 µM 1.66631485040551 0.0533502400194858 no 276 0.0478253602097645 328 730143
SGTC_1644 st010134 20.9 µM 1.66380345044308 0.0536177767856266 no 277 0.048075857117473 295 3818134
SGTC_974 1326-0144 138 µM 1.65836407743851 0.0542008707310209 no 278 0.0486220013356825 388 5411856
SGTC_621 3584-0052 32.1 µM 1.65430337516105 0.0546394353766985 no 279 0.0490329437816604 344 2273927
SGTC_2767 sibutramine 71.45 µM 1.65153267212453 0.0549402843364563 no 280 0.0493149275175666 343 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1355 1499-0035 1.68 µM 1.64521675365349 0.0556309735294234 no 281 0.0499625598782968 354 1548538
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.64478565442229 0.0556783659346472 no 282 0.0500070107822325 418 65057 A dermal irritant. YDR527W RBA50
SGTC_2881 9058953 51.95 µM 1.64420096679613 0.0557426938129096 no 283 0.0500673486622397 387 17122249
SGTC_2194 5927483 104.545 µM 1.64204188636966 0.0559807461331937 no 284 0.0502906619062015 375 760979
SGTC_1307 1187-1599 12.2 µM 1.64139912200949 0.0560517696660658 no 285 0.0503572960140758 333 1538471
SGTC_2882 9058044 58.44 µM 1.64085633203588 0.0561118016584297 no 286 0.0504136207521228 325 18076804
SGTC_3237 9133362 49.47 µM 1.63923243680882 0.0562917055257139 no 287 0.0505824304216249 341 43845137
SGTC_377 3970-0964 33.1 µM 1.63866257835878 0.0563549451903239 no 288 0.0506417758458553 453 16481235
SGTC_829 1635-0120 117 µM 1.63840957844934 0.0563830396324462 no 289 0.0506681411883122 397 285054
SGTC_1943 st076331 65.2 µM 1.63683403124521 0.0565582452025035 no 290 0.0508325764546421 334 24208415
SGTC_120 rhodamine 6G 52.259 µM 1.62876950631531 0.057461771279547 no 291 0.0516809111595528 449 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2361 9034121 116 µM 1.62565836934547 0.0578133543767886 no 292 0.0520111753975132 343 6496917
SGTC_371 0195-0006 7.36 µM 1.62166916104691 0.0582666384704712 no 293 0.0524371026697946 300 3928593
SGTC_1055 3448-0672 86 µM 1.61927965918314 0.0585394858589798 no 294 0.0526935525879505 361 748378
SGTC_1242 0402-0103 60.1 µM 1.61798844379514 0.0586873413805728 no 295 0.0528325440765361 332 432868
SGTC_277 nystatin 15.5 µM 1.61658294884785 0.058848615947221 no 296 0.0529841674869276 370 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2301 7769476 200 µM 1.61530673579551 0.0589953570423928 no 297 0.0531221428482829 320 977820
SGTC_2806 7952793 58.44 µM 1.61485942416932 0.059046857561534 no 298 0.05317057046792 367 2972490
SGTC_1989 st071868 50.2 µM 1.6144449689229 0.0590946066833259 no 299 0.053215472166265 383 16414057
SGTC_2771 fluoxetine 41.05 µM 1.60836552211153 0.0597985016718322 no 300 0.05387757407103 328 3386 A selective serotonin reuptake inhibitor.
SGTC_1440 4100-1550 40 µM 1.60430754781974 0.0602719887694864 no 301 0.0543231390998772 294 742806
SGTC_95 0471-0001 561.058 µM 1.60358994032314 0.0603560242097476 no 302 0.0544022347966715 383 4015405
SGTC_697 0508-1955 564 µM 1.60164630828287 0.0605840938285922 no 303 0.0546169221877138 405 6243113
SGTC_320 4092-0846 5.34 µM 1.59916025583132 0.0608767941533254 no 304 0.0548924994152014 355 1359356
SGTC_3112 9123419 49.47 µM 1.59753042969847 0.061069284235869 no 305 0.0550737601181324 399 17015854
SGTC_1876 myriocin 605 nM 1.59413466462598 0.061471867868928 no 306 0.0554529381432114 351 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_591 4299-0174 154 µM 1.59333471507062 0.0615670065940137 no 307 0.0555425614177678 326 5509088
SGTC_1043 0916-0009 19.3 µM 1.59180909566793 0.0617487686145693 no 308 0.0557138029024079 457 3101130
SGTC_810 3825-7150 143 µM 1.59161531848339 0.0617718851460789 no 309 0.0557355829991618 370 22330411 YGL099W LSG1
SGTC_1400 3771-8998 51.5 µM 1.58937950435329 0.0620390941403305 no 310 0.0559873694931433 329 670767
SGTC_2150 5556613 200 µM 1.58593569350429 0.0624524379378889 no 311 0.056376948947311 403 743190
SGTC_312 4092-0653 6.84 µM 1.58295745308375 0.0628116302733551 no 312 0.0567155811245508 484 1148278
SGTC_335 4077-0256 27.6 µM 1.57769316249516 0.0634504679140742 no 313 0.0573180589323327 428 3121989
SGTC_855 0428-0020 25 µM 1.57745518355829 0.063479466414834 no 314 0.0573454132259351 332 6812414
SGTC_146 3448-8650 53.125 µM 1.57663030114805 0.0635800608403439 no 315 0.0574403081717771 551 2891488 YIL048W NEO1
SGTC_303 1348-1668 34.2 µM 1.57497318948317 0.0637825204936026 no 316 0.0576313165841995 339 5380509
SGTC_1460 k062-0059 9.15 µM 1.57252605636301 0.0640824186470042 no 317 0.0579143005847163 349 1373085
SGTC_746 1095-0025 46.6 µM 1.57016879851449 0.0643723380240106 no 318 0.0581879231702876 399 6749286
SGTC_2639 lactacystin 53 µM 1.56795604880088 0.064645410769194 no 319 0.0584456949337882 409 3870 A proteasome inhibitor.
SGTC_1429 4049-0205 9.46 µM 1.55991216170022 0.0656456823458402 no 320 0.0593903200418043 392 22774478
SGTC_854 0422-0053 192 µM 1.5561975246224 0.0661116354301213 no 321 0.0598305649148424 387 3596728
SGTC_724 3910-0327 137 µM 1.55462863431391 0.0663092002809627 no 322 0.060017270044771 407 2885483
SGTC_1258 0671-0043 57.1 µM 1.55010809817087 0.0668810124534968 no 323 0.0605577863353663 414 4298767
SGTC_2776 terbinafine 19.92 µM 1.54345819649997 0.0677290963393533 no 324 0.0613598213991799 414 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2006 4011487 200 µM 1.54123291144725 0.06801474181607 no 325 0.0616300551011145 456 45595294
SGTC_1420 4'-methoxyflavone 42 µM 1.53217473963628 0.0691870881012768 no 326 0.0627396601169255 369 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_776 4476-4378 112 µM 1.52950360022536 0.0695357540062886 no 327 0.0630698236181851 366 2892008
SGTC_2841 9004761 38.96 µM 1.52192645142807 0.0705321686673736 no 328 0.0640137552436997 376 2991039
SGTC_3000 9075062 71.4286 µM 1.51406271751652 0.0715778384339019 no 329 0.0650049666850646 388 17057871
SGTC_90 0870-0863 4.608 µM 1.51298961856483 0.0717214499457468 no 330 0.0651411479401106 455 1738164
SGTC_1232 0279-0259 161 µM 1.51295703670959 0.0717258137901067 no 331 0.0651452861895907 423 1560000
SGTC_1988 st071872 53.4 µM 1.51198188971866 0.0718565141985172 no 332 0.0652692348931191 356 16414116
SGTC_2775 cyproheptadine 69.59 µM 1.51164991138413 0.0719010514011953 no 333 0.0653114736210414 410 2913 A selective serotonin reuptake inhibitor.
SGTC_1483 3453-0561 55.9 µM 1.5113896161701 0.0719359866177946 no 334 0.0653446066917195 455 4546991
SGTC_230 MPP+ 141.667 µM 1.51107571319427 0.0719781340482196 no 335 0.0653845808552086 402 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_996 3970-0799 1.8 µM 1.51039094613716 0.0720701427187188 no 336 0.0654718487478207 570 6615648 YGL040C HEM2
SGTC_1107 amlodipine 47 µM 1.51002844069988 0.0721188872187311 no 337 0.0655180836184234 436 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1913 st060213 96.1 µM 1.50740363402379 0.0724725876264786 no 338 0.0658536139359619 451 688959
SGTC_504 lovastatin 124 µM 1.50547538276725 0.0727332707402904 no 339 0.066100950608116 337 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_637 1181-0519 7.26 µM 1.50512958801562 0.0727800950708764 no 340 0.0661453816818049 545 6252091 YGR060W ERG25
SGTC_3120 9124077 49.47 µM 1.50306465329891 0.073060190024418 no 341 0.0664111862964808 405 18774327 YGL155W CDC43
SGTC_1548 st061468 90.8 µM 1.5020363369933 0.0731999817776251 no 342 0.0665438623694592 402 390799
SGTC_3117 9124945 49.47 µM 1.50188237398351 0.0732209294758343 no 343 0.0665637447291842 348 17592065
SGTC_2684 capsaicin 100 µM 1.50141946900211 0.0732839384218321 no 344 0.0666235507023842 392 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1617 st002906 78 µM 1.50107918594883 0.0733302829625179 no 345 0.0666675407968214 444 5150859
SGTC_1029 k015-0030 64.7 µM 1.49782326243745 0.0737748546440877 no 346 0.0670895876213983 416 2208316
SGTC_2641 levomentholum 100 µM 1.48414654510768 0.0756648338876677 no 347 0.0688850236930814 347 16666
SGTC_2927 9011802 47.9 µM 1.47945280551794 0.0763218915637362 no 348 0.0695096679652477 437 43912568
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.4780468495961 0.076519548298848 no 349 0.0696976194294046 257 6708630 An antioxidant.
SGTC_2686 alizarin 95.37 µM 1.47275759795338 0.0772666282908787 no 350 0.0704082047503118 412 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_454 lyso-paf C-16 6.67 µM 1.47143632124728 0.0774541140984067 no 351 0.0705865784118612 422 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_344 k064-0035 6.43 µM 1.46875997098344 0.077834939817101 no 352 0.0709489524153348 422 5088750
SGTC_2601 securinine 100 µM 1.46734183093268 0.0780373062687058 no 353 0.071141544867287 422 442872 A GABA receptor antagonist.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.46528903349897 0.0783309441429274 no 354 0.071421038619546 447 390807
SGTC_2104 5389443 200 µM 1.45247428653526 0.0801829713608378 no 355 0.0731848869131988 501 2244536
SGTC_911 3456-4043 236 µM 1.44800645911722 0.0808363979491846 no 356 0.0738076220881546 478 914281
SGTC_1852 st056254 31.4 µM 1.44621994733421 0.0810988002917732 no 357 0.0740577602903377 441 442583
SGTC_2887 9044784 58.44 µM 1.44493963711245 0.081287246934391 no 358 0.074237420754917 457 6465546
SGTC_998 3996-0085 177 µM 1.44463630437671 0.0813319423201506 no 359 0.0742800348756739 496 715391
SGTC_1904 st060225 78 µM 1.4413577723706 0.0818162101672922 no 360 0.0747418168059197 431 66595
SGTC_1119 parthenolide 318.541 nM 1.4412660633207 0.0818297875746811 no 361 0.0747547654685326 536 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2184 6075246 200 µM 1.44082684598019 0.0818948366825794 no 362 0.0748168035494391 452 2267320
SGTC_3204 9114183 49.47 µM 1.4368925918574 0.0824792477153319 no 363 0.0753742576143244 449 17027248
SGTC_235 0330-0087 5 mM 1.4334382917412 0.0829949480016809 no 364 0.0758663109986716 503 46494818 YHR062C RPP1
SGTC_735 3076-0345 636 µM 1.43131324326344 0.0833134040396124 no 365 0.0761702300505346 524 2888990
SGTC_472 calcifediol 10 µM 1.43078995065009 0.0833919645230646 no 366 0.0762452120396777 374 5283731 A vitamin D metabolite.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.43007521624725 0.0834993555827619 no 367 0.0763477162434637 544 688664
SGTC_1625 st003711 30.1 µM 1.4296080342351 0.0835696072769481 no 368 0.0764147741732203 447 24207034 YER133W GLC7
SGTC_2988 9073640 71.4286 µM 1.42777340563818 0.083845916106673 no 369 0.07667854492639 436 9102229
SGTC_634 1611-4317 11.2 µM 1.42533727971898 0.0842138746669074 no 370 0.0770298643921367 504 2843522
SGTC_2185 6113692 200 µM 1.42480854753248 0.0842938955354727 no 371 0.0771062754264693 429 874150
SGTC_3325 9138760 55.175 µM 1.42462672769229 0.0843214262046972 no 372 0.0771325648734329 466 43844959
SGTC_61 0978-8327 98.565 µM 1.42004896276175 0.085016804528427 no 373 0.077796713552493 482 6150059 YHR072W ERG7
SGTC_130 0136-0219 337.655 µM 1.41802781764347 0.0853251877287284 no 374 0.0780913217068039 459 234244
SGTC_76 0433-0009 400.328 µM 1.41409588503299 0.0859275155151968 no 375 0.0786668756021084 384 2841569
SGTC_3225 9130819 49.47 µM 1.4120616863932 0.0862403780560193 no 376 0.0789658993644244 469 4547121
SGTC_2049 5262831 67.185 µM 1.40478541302229 0.0873664543858036 no 377 0.0800425489897786 470 763417
SGTC_2716 st080858 38.6235 µM 1.40452091817751 0.0874075933855573 no 378 0.0800818935597605 450 5296050
SGTC_2071 5230951 39.92 µM 1.40380500237943 0.0875190180328343 no 379 0.0801884619816192 498 1799272
SGTC_1001 4048-4355 44.4 µM 1.40007318136015 0.0881015530194869 no 380 0.080745702535481 459 21824233
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.39930123625867 0.0882224131807723 no 381 0.0808613345412906 534 676296 Flavone; oxidizing agent.
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.39918148098018 0.0882411738230918 no 382 0.0808792842447081 418 15053
SGTC_784 4579-0127 173 µM 1.39597102485527 0.0887452270089003 no 383 0.081361610366179 513 1948547
SGTC_2087 5276107 200 µM 1.39246659802925 0.0892978788962699 no 384 0.0818905747797149 466 144405
SGTC_1304 1165-0502 251 µM 1.39217994216307 0.0893431978704534 no 385 0.0819339575276702 551 767425
SGTC_2704 st078022 71.1 µM 1.38889030901403 0.0898644991297017 no 386 0.082433053922295 471 54697681
SGTC_2486 5283202 22.39 µM 1.38845774088578 0.0899332151298465 no 387 0.0824988521916368 470 1377751
SGTC_1433 4060-0023 7.6 µM 1.38211921957229 0.0909446092276364 no 388 0.0834675490346755 486 3840627
SGTC_767 0929-0023 86 µM 1.37984980030628 0.0913087686576796 no 389 0.0838164477970287 596 1204563
SGTC_2790 5423970 71.43 µM 1.37546590804442 0.0920152834939221 no 390 0.0844935240209326 544 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2884 9058502 51.95 µM 1.37221321889984 0.0925421020587564 no 391 0.0849985357461294 506 6471554
SGTC_2305 7443522 69.23 µM 1.36992807495086 0.0929135453822829 no 392 0.0853546774148403 511 5415886
SGTC_1550 gossypolone 36.6 µM 1.36822849601282 0.0931905207953339 no 393 0.0856202822738773 513 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_138 0850-0259 40.9225 µM 1.36779869087324 0.093260661443151 no 394 0.0856875488060473 647 6813004
SGTC_587 k089-0003 57 µM 1.36652177637985 0.0934692734136237 no 395 0.0858876253210607 343 9659696
SGTC_631 k072-0230 41.5 µM 1.36576787982685 0.0935926006444524 no 396 0.0860059155063106 541 5773147
SGTC_2059 5238311 157 µM 1.36502084145734 0.0937149244556826 no 397 0.0861232498098246 484 703021
SGTC_2751 anetholtrithion 17.25 µM 1.36462588111049 0.0937796449243048 no 398 0.0861853330110569 507 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_570 0987-0065 62.6 µM 1.36391319964531 0.0938965124730591 no 399 0.0862974429921255 381 3104428
SGTC_1306 1185-0270 9.02 µM 1.36362269813937 0.0939441805671173 no 400 0.0863431722688278 550 1548076
SGTC_2102 5377816 72.7585 µM 1.36307556788367 0.094034007097733 no 401 0.0864293479442145 521 1379702
SGTC_2489 cantharidin 73.42 µM 1.36301272932006 0.0940443278381073 no 402 0.0864392494391247 528 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_734 2023-0417 80 µM 1.36187458539349 0.0942314037252121 no 403 0.0866187340073282 514 3935732
SGTC_1231 0242-0792 125 µM 1.36162991917182 0.0942716551558425 no 404 0.0866573540658292 498 3707635
SGTC_2382 9035899 200 µM 1.36121660664109 0.0943396803528945 no 405 0.0867226238275683 517 6462679
SGTC_2537 larixol 68.93 µM 1.36054524530703 0.094450253755153 no 406 0.0868287226055903 547 6708759
SGTC_2675 theaflavin digallate 100 µM 1.3592511970576 0.0946636534266479 no 407 0.0870335014730231 518 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_265 mycophenolic acid 32.932 µM 1.35781711964534 0.094900560016726 no 408 0.087260860642785 544 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2504 purpurogallin 52.29 µM 1.3513140499327 0.0959803364712508 no 409 0.0882974266203083 477 5281571 An antioxidant.
SGTC_414 piperonyl butoxide 100 µM 1.34696751555797 0.0967070598783726 no 410 0.088995347537842 498 5794 A potent inhibitor of cytochrome P450.
SGTC_838 0109-0203 71.4 µM 1.34009565584908 0.0978642400565333 no 411 0.0901071241191524 521 759422
SGTC_2848 9016370 25.97 µM 1.33981683667307 0.0979114048703918 no 412 0.0901524502431724 584 7894410
SGTC_646 4092-0839 27.3 µM 1.33599898432356 0.0985589061542318 no 413 0.0907748026417038 522 877796
SGTC_540 1187-0821 17.3 µM 1.33475496921366 0.0987705646498445 no 414 0.0909782780393944 497 847520
SGTC_2714 st079313 56.9 µM 1.33346913060499 0.0989896884568558 no 415 0.0911889496214788 490 2939799
SGTC_2669 eugenol 100 µM 1.33245229746093 0.0991632218369993 no 416 0.0913558033720203 444 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_742 0kpi-0133 140 µM 1.33222986140196 0.0992012125522557 no 417 0.0913923334062298 543 2728852
SGTC_3353 9151644 39.2805 µM 1.32754324243701 0.100004134433723 no 418 0.092164522722417 540 4909158
SGTC_963 1269-2853 151 µM 1.32618952798345 0.100236936712556 no 419 0.0923884635519256 518 3668223
SGTC_500 h-89 112 µM 1.32600523805415 0.100268660164265 no 420 0.0924189811820503 566 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3072 9116419 49.47 µM 1.32545846735891 0.10036282375146 no 421 0.0925095679826604 459 17170162
SGTC_2107 5363541 170.161 µM 1.3225916212963 0.100857601743743 no 422 0.0929856110545331 524 244052
SGTC_3101 9120531 49.47 µM 1.31818067201973 0.101622340214266 no 423 0.0937215870343412 548 24824904
SGTC_1952 st077036 64.1 µM 1.31808589690568 0.101638817846218 no 424 0.093737447517093 552 2937007
SGTC_2417 cerulenin 830 nM 1.31783470414388 0.101682499711908 no 425 0.0937794938599585 495 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_624 k048-0052 28 µM 1.31734882617529 0.101767031602853 no 426 0.0938608629069953 511 6835531
SGTC_544 k015-0020 52.4 µM 1.31583420467906 0.102030870121832 no 427 0.0941148480509426 510 3008304
SGTC_1145 3546-0597 10.2 µM 1.31206345806523 0.10268987413482 no 428 0.0947493621026906 565 875334
SGTC_1754 st042065 16.137 µM 1.30999578607874 0.103052546641661 no 429 0.0950986305683378 684 1126236 YIL048W NEO1
SGTC_2419 paclitaxel 166.5 µM 1.30743478260241 0.103503038806769 no 430 0.0955325453926311 601 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_247 mechlorethamine 29.705 µM 1.30530163222816 0.103879359332596 no 431 0.0958950792498001 475 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3320 9137005 35.139 µM 1.30308542569516 0.104271382289424 no 432 0.0962727993607322 522 4908713
SGTC_785 1270-0111 65.3 µM 1.30304791258132 0.104278027169449 no 433 0.0962792023225606 529 6741994
SGTC_3149 9097855 49.47 µM 1.3023876342737 0.104395035719107 no 434 0.0963919538026203 523 25236625 YMR079W SEC14
SGTC_546 peri-Naphthalide 147 µM 1.30222304871979 0.104424216889933 no 435 0.0964200741209096 547 223824 A penicillin ester.
SGTC_1325 1431-0015 227 µM 1.29952113307346 0.104904114240978 no 436 0.0968825728818929 525 1103340
SGTC_1475 4092-1048 11.7 µM 1.29761492392331 0.105243642462705 no 437 0.0972098456312339 588 2881759
SGTC_1938 st074717 56.4 µM 1.2933997634205 0.105997255642701 no 438 0.097936415956847 487 17250979
SGTC_2193 5925765 200 µM 1.29132864745279 0.10636896832577 no 439 0.0982948704885303 482 877370
SGTC_3062 9077494 49.47 µM 1.29110548785573 0.106409075909044 no 440 0.0983335506911 536 16459633
SGTC_817 1391-0715 46 µM 1.29010977383934 0.106588164675223 no 441 0.0985062734138632 527 1353946
SGTC_871 0574-0004 149 µM 1.28753525701344 0.107052224650044 no 442 0.0989538944917782 596 9551173
SGTC_2709 st078560 56 µM 1.28658050341667 0.107224690092094 no 443 0.0991202714075703 549 17250903
SGTC_538 2922-0838 53.3 µM 1.2849578144739 0.107518269936555 no 444 0.0994035130141284 634 777039
SGTC_2869 9037858 32.47 µM 1.28219737678631 0.10801902347572 no 445 0.0998867081011576 503 27187042
SGTC_448 monastrol 171 µM 1.28134317959208 0.108174317665511 no 446 0.100036576270565 555 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2540 epiandrosterone 100 µM 1.27780514496592 0.108819248391845 no 447 0.100659069929857 714 441302 A steroid.
SGTC_1968 st069590 43.6 µM 1.27524059476623 0.109288452626219 no 448 0.101112048447594 548 6384066
SGTC_3328 9140624 29.0385 µM 1.27293722977602 0.109711108399559 no 449 0.10152015842818 573 4904392
SGTC_3260 9137109 49.47 µM 1.26920069945842 0.110399236198686 no 450 0.102184745834019 455 17478346
SGTC_1114 scopoletin 1.73284 µM 1.26645781881102 0.110906337139092 no 451 0.1026746109699 548 5280460 A coumarin with genotoxic properties.
SGTC_708 3448-5400 146 µM 1.26455594946206 0.111258931013398 no 452 0.103015276201616 606 3462195
SGTC_1285 0929-0069 65.5 µM 1.25980358673753 0.112143493556087 no 453 0.103870112793844 572 1206237
SGTC_2043 5101342 149 µM 1.25824641267457 0.11243442260036 no 454 0.104151327233955 575 678451
SGTC_2023 5144124 124 µM 1.2572834668193 0.112614600745307 no 455 0.10432550429127 569 2830192
SGTC_2992 9074591 71.4286 µM 1.25557950815706 0.11293393595723 no 456 0.104634232387879 561 17741321
SGTC_10 0279-0212 42.575 µM 1.25428080555106 0.113177756683334 no 457 0.104869979036981 685 39851 YBR002C RER2
SGTC_2433 5607874 27.82 µM 1.25247058775351 0.11351823643324 no 458 0.105199219598444 573 2252428
SGTC_370 0180-0345 38.7 µM 1.24355622308805 0.115205573385158 no 459 0.106831468186017 522 3989527
SGTC_2447 5741742 33.78 µM 1.24352272975374 0.115211946544103 no 460 0.106837635187246 605 1776504
SGTC_3015 9080845 49.47 µM 1.24329766058177 0.115254779525059 no 461 0.106879082986955 617 5296973
SGTC_896 0964-0007 44.5 µM 1.23884907675074 0.116103714786082 no 462 0.107700697599042 609 6756758
SGTC_1665 st014639 11.4 µM 1.23867162716752 0.116137669777147 no 463 0.107733565101194 640 981133 YIL048W NEO1
SGTC_726 3448-4391 34.2 µM 1.23826464881265 0.116215571732679 no 464 0.107808973586656 634 1356692
SGTC_309 k408-0051 1.48 µM 1.23329939546624 0.117168985021668 no 465 0.108732041681028 680 3640463
SGTC_528 3492-0019 172 µM 1.23170331895881 0.117476632536486 no 466 0.109029964792486 814 2869262
SGTC_2120 5538279 151.968 µM 1.22976510448762 0.11785099638117 no 467 0.109392539538879 594 2058197
SGTC_1153 4055-0057 267 µM 1.22608813318031 0.118563517018905 no 468 0.110082755503086 624 882706
SGTC_3303 9125618 40.5795 µM 1.22434657234571 0.118902055612784 no 469 0.110410757524386 681 22695467
SGTC_1776 st049249 45.9 µM 1.22170917599206 0.119416032689991 no 470 0.110908812517971 615 1822314
SGTC_266 formosanin C 406 nM 1.21811051376147 0.120119867604729 no 471 0.111590989526982 627 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2254 7938975 95.19 µM 1.21750625882209 0.120238335277007 no 472 0.111705828284417 709 2969277
SGTC_2084 5306078 60.6385 µM 1.21630619716971 0.120473858327215 no 473 0.111934150834649 585 679340
SGTC_119 0121-0043 24.815 µM 1.21335688461458 0.121054067719631 no 474 0.112496701495014 775 1092378
SGTC_501 nsc-95397 161 µM 1.21274016308064 0.121175641594922 no 475 0.112614589576578 593 262093
SGTC_2629 bisabolol 100 µM 1.20800410269693 0.122112120135086 no 476 0.113522842125735 642 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3010 9080089 71.4286 µM 1.20759259011917 0.122193729333439 no 477 0.113602005411876 621 17027233
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.20744956684333 0.122222101987591 no 478 0.113629528226263 665 165506
SGTC_1189 1431-2119 7.28 µM 1.20640991342885 0.122428485232564 no 479 0.113829737756602 644 3107275
SGTC_1994 st072947 40.9 µM 1.20380581468888 0.122946502109459 no 480 0.114332320873877 625 5286565 YDL195W SEC31
SGTC_1471 k673-0312 37 µM 1.20297156666205 0.123112778333541 no 481 0.11449366186165 588 24099884
SGTC_599 1935-0052 86.5 µM 1.19938331142488 0.123829759873215 no 482 0.115189466856535 651 9557311
SGTC_21 0849-0113 22.993 µM 1.19836320557751 0.124034123239761 no 483 0.115387825081614 636 1560156
SGTC_1572 epiandrosterone 68.9 µM 1.19707666574998 0.124292199135693 no 484 0.115638337016567 663 441302 A steroid.
SGTC_2007 4011539 71.82 µM 1.19458852295713 0.124792377852797 no 485 0.116123917780366 630 45595301
SGTC_3004 9076122 71.4286 µM 1.19269400710788 0.125174164771474 no 486 0.116494616772702 627 44782551
SGTC_1370 2001-0092 44.6 µM 1.19266540679574 0.125179934610761 no 487 0.116500219405652 728 790957
SGTC_1812 st052057 4.327 µM 1.1895456817524 0.12581042458732 no 488 0.117112503007928 650 3645418
SGTC_17 0960-0276 49.807 µM 1.18922091005586 0.125876187343503 no 489 0.117176374148149 672 6821114
SGTC_1597 7-benzyloxygramine 47.5 µM 1.18891458834572 0.125938236142964 no 490 0.117236639437319 745 260807
SGTC_1276 0871-0068 94.2 µM 1.1864091893619 0.126446532663548 no 491 0.117730372231739 601 3414906
SGTC_1338 1486-1223 76 µM 1.18603655989859 0.126522253829406 no 492 0.117803930925709 669 3444526
SGTC_800 3448-7362 155 µM 1.18577279425093 0.12657587212189 no 493 0.117856019078386 875 15991913
SGTC_2797 7859098 81.82 µM 1.18553048282446 0.126625143145887 no 494 0.117903884834682 632 972681
SGTC_3296 9122258 64.045 µM 1.18494180947972 0.12674489821092 no 495 0.118020227581493 629 4730474
SGTC_2646 retinol 96.75 µM 1.18400132857589 0.126936385833532 no 496 0.118206268450792 617 445354 A vitamin A analog and teratogen.
SGTC_1314 1222-0010 41.1 µM 1.18394442202073 0.126947978811285 no 497 0.118217532048923 627 3526027
SGTC_1831 st055328 12 µM 1.18110985921703 0.127526367474722 no 498 0.118779541896106 658 1103068
SGTC_2256 7954252 200 µM 1.17830462872253 0.128100572401362 no 499 0.119337591576735 535 2972920
SGTC_1175 0741-0056 27.6 µM 1.17829962891775 0.12810159741616 no 500 0.119338587846094 706 765927
SGTC_2302 7771753 200 µM 1.17703490979618 0.128361061703 no 501 0.119590786410729 658 2203047
SGTC_626 0214-0009 33 µM 1.17429009103393 0.128925431404634 no 502 0.120139425460319 664 3437874
SGTC_2204 7233102 200 µM 1.17427852020055 0.128927814152372 no 503 0.120141742006172 565 2172480
SGTC_2342 7990637 118.86 µM 1.1741397179745 0.12895639966788 no 504 0.120169533445215 661 2033102 YER133W GLC7
SGTC_2429 5902844 64.44 µM 1.17264656383098 0.129264184104657 no 505 0.120468784182021 677 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_931 2812-0076 566 µM 1.17224500667143 0.129347044044034 no 506 0.120549351799288 671 3450959
SGTC_1222 0366-0074 1.18 µM 1.17002343040035 0.129806123779458 no 507 0.120995769971776 677 286520
SGTC_942 3253-1115 227 µM 1.16875271897795 0.130069217789212 no 508 0.121251637400715 633 46497897
SGTC_852 0418-0143 439 µM 1.16808361845597 0.130207899707255 no 509 0.121386518719412 719 5369229
SGTC_56 0957-0365 83.25 µM 1.16744886876769 0.13033955639608 no 510 0.121514572867005 657 6752360
SGTC_2642 cholecalciferol 100 µM 1.16718913692894 0.130393455250352 no 511 0.12156699843179 624 9821465 A vitamin D precursor, similar to steriods.
SGTC_3065 9113888 49.47 µM 1.1652985575555 0.130786247739909 no 512 0.121949081397477 599 16648368
SGTC_2148 5546263 113.568 µM 1.16476930131665 0.13089635398932 no 513 0.122056194160615 633 792097
SGTC_141 0443-0274 32.331 µM 1.16322155297295 0.131218714430615 no 514 0.122369812039085 757 1627241
SGTC_3316 9136639 10.545 µM 1.15900599762647 0.132099496674794 no 515 0.123226870165344 629 4903665
SGTC_1745 st081495 74 µM 1.15875714485764 0.132151618161588 no 516 0.12327759520418 721 13842402 YBL026W LSM2
SGTC_3314 9135860 59.4275 µM 1.15292122422709 0.133378001094428 no 517 0.124471359828988 687 25252478
SGTC_1227 3909-8010 46.6 µM 1.15185016870317 0.133603924406675 no 518 0.124691324071243 644 15982272
SGTC_1354 1498-1681 81 µM 1.15071161810997 0.133844373194512 no 519 0.124925447619398 702 5754243
SGTC_22 0964-0034 14.468 µM 1.14781266297958 0.134457941367223 no 520 0.125522954319002 694 138402
SGTC_1054 3429-0080 167 µM 1.1469280276779 0.134645559694845 no 521 0.125705683942673 681 1162877
SGTC_1866 st057638 64 µM 1.14323334827245 0.135431089403555 no 522 0.126470859900807 668 688802
SGTC_350 k064-0020 19.8 µM 1.1403001680384 0.1360569481793 no 523 0.127080633919958 724 2790705
SGTC_271 rotenone 740 µM 1.13865097113146 0.136409708941416 no 524 0.127424379894715 689 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_858 0438-0351 2.77 µM 1.13862296423358 0.136415704973016 no 525 0.127430223016623 718 2799119
SGTC_966 1300-0360 30.2 µM 1.13638879341694 0.136894602301172 no 526 0.127896941919165 666 70588
SGTC_2472 5377652 49.4 µM 1.13630641817937 0.13691228147377 no 527 0.127914172803993 707 1610903
SGTC_2532 xanthone 78.9 µM 1.13469579868906 0.137258262233474 no 528 0.128251399123101 612 7020 An insecticide.
SGTC_1075 aripiprazole 15.2 µM 1.13444477263002 0.137312239440456 no 529 0.128304013707729 722 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3113 9123498 49.47 µM 1.13261727962222 0.137705635420712 no 530 0.128687504487561 687 8897275
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.13039616174648 0.138184799778935 no 531 0.129154665365491 640 6708760
SGTC_1716 st033144 30.6155 µM 1.12813959730575 0.138672773951234 no 532 0.12963048427042 708 674617
SGTC_2019 4016004 108 µM 1.12714690649749 0.138887811202002 no 533 0.129840187024319 615 45595336
SGTC_2525 harmine 47.85 µM 1.12698117665072 0.13892373380239 no 534 0.129875219791326 634 5280953 A monoamine oxidase inhibitor
SGTC_1547 harmine 94.2 µM 1.12081710269919 0.140264315639371 no 535 0.131182861326809 760 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3251 9135047 49.47 µM 1.12050736234566 0.140331909985815 no 536 0.131248808494067 647 17682963
SGTC_2919 7978188 46.38 µM 1.11963375419624 0.14052267583799 no 537 0.131434932729027 697 2980291
SGTC_2957 9076800 11.52 µM 1.11908988891773 0.140641526106344 no 538 0.131550896473258 621 16459615
SGTC_1401 3807-4679 7.6 µM 1.11874467598061 0.140717000487186 no 539 0.131624539905321 644 3291456
SGTC_326 k292-0812 17.5 µM 1.11694149249157 0.141111679674903 no 540 0.132009671048101 669 3579357
SGTC_2186 6124449 200 µM 1.11607713969323 0.141301134341933 no 541 0.132194558258362 688 3834182 YLR033W RSC58
SGTC_1606 st000094 49.2 µM 1.11562238627515 0.141400879447573 no 542 0.132291902780054 739 1242210
SGTC_1084 voriconazole 435 nM 1.11336969198135 0.141895686476949 no 543 0.132774843083223 706 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.11189132923435 0.142221047074003 no 544 0.133092438616182 768 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2508 celastrol 40.54 µM 1.11049758726837 0.142528246162004 no 545 0.133392333610559 627 122724 Celastrol is a natural product and antioxidant.
SGTC_1591 genipin 88.4 µM 1.10957419048463 0.142732021950037 no 546 0.133591279060203 665 442424 A DNA cross-linking agent.
SGTC_2101 5377231 179.231 µM 1.10912990830539 0.142830136569616 no 547 0.133687072133955 694 2844213
SGTC_3025 9087895 49.47 µM 1.10518327258516 0.143703706747052 no 548 0.134540091741703 763 17173641
SGTC_463 ikarugamyin 104 µM 1.10452593156433 0.143849555766787 no 549 0.13468253056058 650 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3150 9097574 49.47 µM 1.0986592367302 0.145155664144926 no 550 0.135958364553533 691 17217476
SGTC_510 ag-490 170 µM 1.09601273068701 0.145747462594369 no 551 0.136536601641036 767 5328779
SGTC_2402 5553605 200 µM 1.09590475736588 0.14577164143423 no 552 0.136560228469192 735 6758546
SGTC_612 0302-0167 22.4 µM 1.09518441475656 0.145933019243931 no 553 0.136717926096177 772 235821
SGTC_1738 st035555 74 µM 1.09231536849107 0.146576960439861 no 554 0.137347253768819 716 5331140
SGTC_315 k915-0449 187 µM 1.0900269690417 0.147091943894045 no 555 0.137850632167231 808 20970215 YNL149C PGA2
SGTC_828 2074-0507 139 µM 1.08968779865292 0.147168374202059 no 556 0.137925346318236 733 X828
SGTC_187 1488-2104 32.728 µM 1.08604688123953 0.147990513061956 no 557 0.138729125722707 741 2852859
SGTC_422 cantharidin 155 µM 1.08317830521953 0.148640414162563 no 558 0.139364643658862 716 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_84 0443-0269 128.823 µM 1.08172132378236 0.148971235661013 no 559 0.139688187539196 754 6150058
SGTC_2016 5121758 140 µM 1.07994328367188 0.149375622549418 no 560 0.140083718564422 772 2795203
SGTC_2863 9028737 58.44 µM 1.07752951780081 0.149925766760756 no 561 0.140621885501709 698 6460917
SGTC_627 1391-0720 175 µM 1.07500595701041 0.150502378383538 no 562 0.141186030655198 698 997839
SGTC_2736 butenafine 14.65 µM 1.0746358626542 0.150587065759261 no 563 0.141268894551935 770 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_394 menadione 8.33 µM 1.07333641319511 0.150884665472161 no 564 0.141560101543669 757 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2687 chenodiol 100 µM 1.07285860909728 0.150994190465577 no 565 0.141667279773205 688 5702181 A cholesterol synthesis inhibitor.
SGTC_678 1218-2179 85.9 µM 1.07137646677622 0.151334272165709 no 566 0.142000094948665 686 6820081 YOR116C RPO31
SGTC_1781 st038725 66.3 µM 1.06692316368821 0.152359157663278 no 567 0.143003266978061 796 4270275 YIL048W NEO1
SGTC_865 0488-0499 301 µM 1.06689560156446 0.15236551513631 no 568 0.143009490625586 787 9634651
SGTC_849 0386-0493 241 µM 1.06484725774691 0.152838478442397 no 569 0.143472527822627 714 726119
SGTC_2624 nerol 100 µM 1.06273877230894 0.15332634430017 no 570 0.143950216333217 721 637566 A natural product oil.
SGTC_2932 9016711 44.54 µM 1.06149859609873 0.153613780286397 no 571 0.14423168529428 785 7117328
SGTC_2552 juarezic acid 87.02 µM 1.06088216206064 0.153756784040211 no 572 0.144371728401112 869 1549512
SGTC_568 1193-0097 7.48 µM 1.06047753562299 0.153850699396056 no 573 0.144463702303036 749 3646150
SGTC_3084 9116877 49.47 µM 1.05934040867944 0.154114834177481 no 574 0.144722389110954 676 27241325
SGTC_244 nsc-207895 1.295 µM 1.05689341487567 0.154684244955948 no 575 0.145280117077527 623 42640
SGTC_1956 st077085 54 µM 1.05640370628812 0.154798365937604 no 576 0.145391906715474 769 24208685
SGTC_284 0988-0104 32.6 µM 1.05419111723553 0.155314677717049 no 577 0.145897713021794 783 4666532
SGTC_1435 4092-0789 56.7 µM 1.05386954392617 0.155389811933987 no 578 0.145971324210819 751 2248285
SGTC_2265 7929201 200 µM 1.05315971986268 0.155555744152408 no 579 0.146133898013779 739 1265108
SGTC_2783 7738165 71.43 µM 1.05305149827117 0.155581052867706 no 580 0.146158695112349 641 17201110
SGTC_978 1416-0512 87.4 µM 1.05295028410556 0.155604725283388 no 581 0.146181889138497 778 6814003
SGTC_2965 9082772 38.63 µM 1.05180352806375 0.15587309958738 no 582 0.146444850024463 788 16459634
SGTC_3089 9117425 49.47 µM 1.04294677802983 0.157956110812709 no 583 0.148486471457347 692 9401657
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.03783424631966 0.15916680477778 no 584 0.149673615040609 769 97141
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.0363788835474 0.1595125564169 no 585 0.15001270889867 822 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1462 k081-0014 26.5 µM 1.0363048487136 0.159530158059532 no 586 0.150029972407274 597 3270634
SGTC_208 k072-0098 12.366 µM 1.02974058958366 0.161095851579206 no 587 0.151565898117906 858 5948901
SGTC_3331 9141060 1.957 µM 1.0279504276413 0.161524571586558 no 588 0.151986573427349 732 4906567 YPR165W RHO1
SGTC_1439 4092-1168 46 µM 1.02741146135424 0.161653792413431 no 589 0.152113378421515 789 2886240
SGTC_19 0279-0214 38.434 µM 1.02739218925643 0.161658414277201 no 590 0.152117913954266 854 3566274 YBR002C RER2
SGTC_3224 9130643 49.47 µM 1.02648244970337 0.161876687395498 no 591 0.152332115996609 731 17644395
SGTC_447 ml7 120 µM 1.02636859706476 0.161904017485034 no 592 0.152358937173494 799 4216 Selective myosin light chain kinase inhibitor.
SGTC_1848 st056003 16.4 µM 1.02517904247168 0.162189747369229 no 593 0.15263935752414 809 146492
SGTC_2316 5844804 197.44 µM 1.0237766485227 0.162527022515681 no 594 0.152970391184037 925 776813
SGTC_523 1934-0222 13.7 µM 1.02275659176707 0.162772632223446 no 595 0.153211473329605 768 1361595
SGTC_529 4076-0302 30.3 µM 1.02193597401086 0.162970396043351 no 596 0.153405602337041 766 5816522
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.02188806619915 0.162981946354525 no 597 0.153416940654933 780 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_638 3970-0837 4.09 µM 1.02012170286239 0.163408178404279 no 598 0.153835372526681 776 4118451 YLR208W SEC13
SGTC_2842 9000675 19.48 µM 1.01958819543423 0.163537058579393 no 599 0.153961902902286 712 2989072
SGTC_2405 ticlatone 3.52 µM 1.01930615602254 0.163605217919669 no 600 0.154028821171604 749 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.01704453585129 0.164152441504837 no 601 0.154566121754413 799 688667
SGTC_71 0417-1750 47.813 µM 1.01694022144787 0.164177710116398 no 602 0.154590933922121 825 6811472
SGTC_2171 5739187 198.077 µM 1.01568036208812 0.164483091500988 no 603 0.154890811266464 724 2262761
SGTC_1177 0983-0204 23.6 µM 1.01554173389284 0.164516716508086 no 604 0.154923831617242 837 766818
SGTC_3148 9097893 49.47 µM 1.01241336163477 0.165276704371718 no 605 0.15567022616703 724 17174100
SGTC_953 1188-0045 9.7 µM 1.00873514646618 0.166173169003012 no 606 0.156550835615 799 6144426
SGTC_1395 3486-0190 4.35 µM 1.00440181619784 0.167233322272899 no 607 0.157592487479968 846 6748079
SGTC_2900 5328528 85.29 µM 1.003336708237 0.167494567968311 no 608 0.157849215224617 842 795359
SGTC_1434 4073-0095 163 µM 1.00331346511445 0.167500271884336 no 609 0.157854820679087 835 24133745
SGTC_662 k832-1615 104 µM 1.00312490566367 0.167546549435052 no 610 0.157900299668389 777 5878478
SGTC_1020 4335-0961 93.3 µM 1.00148746732259 0.167948767032232 no 611 0.158295598072868 751 669075
SGTC_1351 1496-0003 46.5 µM 0.998939408387489 0.168575902932101 no 612 0.158912022143267 837 3891978
SGTC_2656 pseudo-anisatin 100 µM 0.998773620078959 0.168616759342677 no 613 0.158952183932359 814 6708809 A neurotoxin.
SGTC_13 0199-0087 65 µM 0.996308881052323 0.169224913394537 no 614 0.159550045001787 835 4589825
SGTC_1779 st039427 55 µM 0.994124403534196 0.16976509085016 no 615 0.160081152974569 891 1124498
SGTC_2389 9091542 195.52 µM 0.993570878170979 0.16990214197205 no 616 0.160215913925429 829 3626624 YOL127W RPL25
SGTC_2617 dihydrotanshinone i 20.83 µM 0.991295256978813 0.170466323566184 no 617 0.160770714160613 838 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1933 st074711 15.9 µM 0.990149366052361 0.170750871318466 no 618 0.161050558587822 833 17250958
SGTC_2915 7971052 15.16 µM 0.989814258188648 0.170834142754799 no 619 0.161132457190859 650 5741558
SGTC_1838 st055369 84.5 µM 0.989511739799518 0.170909338300547 no 620 0.161206414432243 788 676036
SGTC_2837 9008476 45.46 µM 0.989383084621815 0.170941323918522 no 621 0.161237873716936 813 2992805
SGTC_1151 3909-8316 15.3 µM 0.987645921021667 0.171373583921282 no 622 0.161663044083051 816 800431
SGTC_2703 st077852 53.4 µM 0.984612404587635 0.172130090327001 no 623 0.162407247091363 774 6281836
SGTC_3198 9112019 49.47 µM 0.984436064924227 0.172174131833789 no 624 0.162450576410545 801 45595555
SGTC_567 1080-0542 68.4 µM 0.978215635740559 0.173732307427757 no 625 0.163983842409039 774 5950415
SGTC_1917 st066507 28.5 µM 0.977715688015509 0.173857929237745 no 626 0.164107480242171 833 3156428
SGTC_300 r073-0011 5.04 µM 0.97651720357626 0.174159307450789 no 627 0.164404113412901 906 2735780
SGTC_2853 9015042 58.44 µM 0.975366723933104 0.174448926250972 no 628 0.164689191838877 754 6457456
SGTC_3334 9142812 21.919 µM 0.975180769074721 0.174495766754783 no 629 0.164735299815964 805 45283678
SGTC_2903 5923464 63.88 µM 0.973338733424741 0.174960191837244 no 630 0.165192488873844 813 2876576
SGTC_2318 6029776 164 µM 0.970964987676882 0.175559830316746 no 631 0.165782857011663 821 818325
SGTC_1016 4226-1401 38 µM 0.968479507714413 0.176189088364952 no 632 0.16640247422922 830 2901613
SGTC_3261 9137475 49.47 µM 0.967308355992827 0.176486087305455 no 633 0.166694953867801 647 17027690
SGTC_722 3534-0461 190 µM 0.966216114301955 0.176763360221358 no 634 0.16696802554494 842 658262
SGTC_3030 9087619 49.47 µM 0.965763181476693 0.17687842100406 no 635 0.167081347994631 845 25236973
SGTC_706 4262-0057 46.9 µM 0.965711016622844 0.176891675740992 no 636 0.167094402670383 824 883298
SGTC_1865 st057639 52.2 µM 0.962599498555341 0.177683426697566 no 637 0.167874274643127 843 688818
SGTC_1934 st074720 32.6 µM 0.958974874289756 0.178608556464249 no 638 0.168785701482541 870 17250992
SGTC_1290 0986-0249 10.2 µM 0.958159018564536 0.178817208615067 no 639 0.16899128938695 792 53329
SGTC_516 3992-2719 87.3 µM 0.957638780633273 0.17895033766401 no 640 0.169122468357994 797 5350887 YDR037W KRS1
SGTC_937 3122-0005 46.7 µM 0.956543981518442 0.179230700776388 no 641 0.169398737536639 898 759535
SGTC_2821 7996764 71.43 µM 0.954503303789803 0.179754027404839 no 642 0.169914468885138 871 2987135
SGTC_50 0929-0078 56.389 µM 0.953930283474142 0.179901149465187 no 643 0.170059466572336 784 1377751
SGTC_1636 st007707 68.9 µM 0.953179217631205 0.180094098920603 no 644 0.170249637151624 870 403051
SGTC_1492 4158-0558 28.5 µM 0.952868951896395 0.180173844358343 no 645 0.170328236479854 846 3967268
SGTC_1201 1889-3372 45.9 µM 0.95286877032147 0.180173891033768 no 646 0.170328282484864 826 5392199
SGTC_2274 7947094 46.08 µM 0.952616019425061 0.180238870223911 no 647 0.170392328821772 910 2971028
SGTC_999 SEC7.066 22.7 µM 0.947536209037452 0.181547944800059 no 648 0.171682807201105 921 740511 YDR170C SEC7
SGTC_2161 5662504 8.5105 µM 0.947057789973778 0.181671539963415 no 649 0.171804665966551 802 2859334
SGTC_1303 1160-0052 261 µM 0.946529330599291 0.181808123761915 no 650 0.171939334759121 884 3562476
SGTC_3165 9101544 49.47 µM 0.945336880817497 0.18211655616677 no 651 0.172243457645274 861 5002184
SGTC_825 1988-2224 89.6 µM 0.938040978566598 0.184010789263163 no 652 0.174111675673715 866 1180859
SGTC_610 4215-0184 155 µM 0.935365647893968 0.184708447454972 no 653 0.174799947013466 898 5605015
SGTC_1219 1469-0211 33.1 µM 0.93445527504956 0.184946224048914 no 654 0.175034548180715 874 6822282
SGTC_2368 9071271 200 µM 0.933505088789883 0.185194602108536 no 655 0.175279622130308 843 27209959
SGTC_1767 st044992 70.3 µM 0.933000906455953 0.185326479122527 no 656 0.175409750166944 854 9600693
SGTC_1332 1480-0653 17.5 µM 0.93299885044563 0.1853270170245 no 657 0.175410280942753 874 5749438
SGTC_1560 lithocholic acid 53.1 µM 0.932576555852574 0.185437520038458 no 658 0.17551932131209 817 9903 A bile acid which acts as a detergent.
SGTC_1463 k081-0032 34.1 µM 0.932247415367981 0.185523675510067 no 659 0.175604338213362 753 977755
SGTC_515 4092-1064 102 µM 0.92931885830088 0.186291345040516 no 660 0.176361932429412 940 717353
SGTC_980 1473-0395 201 µM 0.927135891167526 0.186864849729492 no 661 0.176927991654348 810 768876
SGTC_2519 cryptotanshinone 88.04 µM 0.922805472115598 0.188005757805355 no 662 0.178054294318042 898 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_518 1021-0119 62.6 µM 0.922752007222555 0.188019870682231 no 663 0.178068228241443 818 1097762
SGTC_673 1082-0474 110 µM 0.921216516308691 0.188425466066579 no 664 0.178468698452788 960 3098046
SGTC_2565 isoliquiritigenin 100 µM 0.920912425081607 0.188505854836611 no 665 0.178548075506634 715 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2739 tacrine 100.86 µM 0.920168385954297 0.188702636258272 no 666 0.178742386079118 837 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_675 1309-0189 238 µM 0.918888632426944 0.189041398013292 no 667 0.17907691318097 841 4246530
SGTC_413 propylparaben 100 µM 0.917647883339707 0.189370192350507 no 668 0.179401620343841 872 7175 A pharmaceutical preservative.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.916829479926572 0.189587259039036 no 669 0.17961600105273 963 688801
SGTC_2363 9053361 176 µM 0.916382419410596 0.189705898368906 no 670 0.179733176481137 897 6469797 YMR079W SEC14
SGTC_3294 9122953 26.2835 µM 0.914399308610747 0.190232719596398 no 671 0.180253532497988 930 16459826
SGTC_765 1319-0117 244 µM 0.914362350016239 0.190242546317031 no 672 0.180263239170481 853 3487746 YGL099W LSG1
SGTC_393 acivicin 6.25 µM 0.913166222741766 0.190560746469641 no 673 0.180577562829756 830 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1977 st070720 65.3 µM 0.911396648973833 0.191032096761988 no 674 0.18104320931147 845 682188
SGTC_2332 7982454 138.89 µM 0.911360372874823 0.191041766872735 no 675 0.181052762883954 897 2981748
SGTC_1451 4152-0210 104 µM 0.909626829865443 0.19150422689652 no 676 0.181509672101219 932 659563
SGTC_3127 9126946 49.47 µM 0.906783459490377 0.192264240866641 no 677 0.182260659216364 786 27243249
SGTC_145 3737-0113 38.366 µM 0.906696328625192 0.192287559462121 no 678 0.1822837027233 1024 6849351
SGTC_1845 st056753 3.01 µM 0.906160401355372 0.192431026250665 no 679 0.182425479487213 901 5375839
SGTC_759 3486-0358 89.3 µM 0.905929974875307 0.1924927311286 no 680 0.182486458782071 961 875103
SGTC_2 0422-0095 29 µM 0.905619826090854 0.192575803581439 no 681 0.182568555621006 790 6790840
SGTC_430 0958-0115 16.4 µM 0.904447574614578 0.192889985626084 no 682 0.182879060611711 854 6833180
SGTC_1605 st000082 49.1 µM 0.903548302074877 0.193131217058797 no 683 0.183117482434998 920 1114022
SGTC_93 0109-0045 59.227 µM 0.89996970409292 0.194093005639635 no 684 0.184068186750666 1060 88733
SGTC_2645 abamectin 100 µM 0.898790241772018 0.194410637678201 no 685 0.18438219939109 884 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3190 9110366 49.47 µM 0.897186540011294 0.194843025713087 no 686 0.184809693157762 830 17123768
SGTC_1870 st057514 26.5 µM 0.896732002275189 0.194965683899396 no 687 0.184930969824315 893 5393161
SGTC_758 0868-0029 16 µM 0.895994132379427 0.195164899944812 no 688 0.185127948524924 944 762687
SGTC_2103 5378138 10 µM 0.895181338633475 0.195384487670657 no 689 0.185345079370689 993 244142
SGTC_3085 9117376 49.47 µM 0.894976358157145 0.195439889734137 no 690 0.185399863094069 913 16480349
SGTC_2089 5281248 129.67 µM 0.894538871817944 0.195558165324804 no 691 0.185516820679459 897 2737878
SGTC_853 0419-0306 21 µM 0.892907280826561 0.195999653451797 no 692 0.185953413876354 836 762713
SGTC_738 1315-0003 72.4 µM 0.892572497438507 0.196090316355034 no 693 0.186043076404099 941 6251474
SGTC_1369 1866-0067 208 µM 0.890169379777485 0.196741852476025 no 694 0.186687471822247 971 3531355
SGTC_2391 6285546 200 µM 0.890053380736559 0.196773335409383 no 695 0.186718611856154 936 846083
SGTC_489 paxilline 115 µM 0.889535777181018 0.196913853731985 no 696 0.186857602119185 874 105008 A toxic potassium channel blocker.
SGTC_1750 st081859 2.357 µM 0.888011522943162 0.19732800896372 no 697 0.187267276516381 1035 5291695
SGTC_1964 st076914 61 µM 0.884606192148986 0.198255173045332 no 698 0.188184532907672 973 24208661
SGTC_2935 9038016 29.96 µM 0.88226447281318 0.198894272460924 no 699 0.188816901930569 964 6463195
SGTC_3265 9137266 49.47 µM 0.880839953485666 0.199283657419416 no 700 0.189202225729682 916 17224265
SGTC_2855 9016525 58.44 µM 0.880740220373656 0.199310936132078 no 701 0.189229221052347 958 43811474
SGTC_3258 9138477 49.47 µM 0.880567462573888 0.199358193666835 no 702 0.18927598798961 946 4970355
SGTC_1950 st077106 7.18 µM 0.879070506152354 0.199767965404539 no 703 0.189681524130591 923 13831864
SGTC_1889 st059080 5.18 µM 0.877324593200607 0.20024652518166 no 704 0.19015517896025 973 176925 Isolated from Daphnopsis sellowiana.
SGTC_2224 6650123 117.647 µM 0.876119559800029 0.200577229780775 no 705 0.19048252021425 922 2908370
SGTC_1161 k007-0610 110 µM 0.87483419305493 0.200930341968701 no 706 0.190832064732837 1026 5843850
SGTC_2701 st077767 14.721 µM 0.87402431260868 0.201153021365919 no 707 0.19105250678113 970 5721188
SGTC_3191 9110352 49.47 µM 0.873716019426826 0.201237826504851 no 708 0.191136462386504 912 17122424
SGTC_42 0133-0086 60.653 µM 0.873521665327395 0.201291300351257 no 709 0.19118940127895 891 162923 Model of phenazepam hydroxylation.
SGTC_2741 miltefosine 3.04 µM 0.872864431242722 0.201472192331598 no 710 0.191368487730898 857 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1397 3532-0190 20.1 µM 0.872594382596119 0.201546546640682 no 711 0.191442101734398 893 5322280
SGTC_652 0437-0092 114 µM 0.870068189068265 0.202242896418545 no 712 0.192131570373225 939 3091274
SGTC_2661 dactinomycin 12.96 µM 0.869949545120515 0.202275636180744 no 713 0.192163988921109 984 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2124 5246320 200 µM 0.869597413231463 0.20237282553705 no 714 0.19226022596 914 579342
SGTC_1919 st067113 52.3 µM 0.868129748673224 0.202778205597576 no 715 0.192661653548281 911 1268243
SGTC_2213 7173844 200 µM 0.866607595196187 0.203199148013312 no 716 0.193078525293367 980 892728
SGTC_151 3013-0144 2.285 µM 0.865550154341598 0.203491883735323 no 717 0.193368450252063 941 906558 YHR107C CDC12
SGTC_1983 st071813 46.9 µM 0.864409017804784 0.203808071326572 no 718 0.193681620391033 929 11838595
SGTC_1841 st054148 70 µM 0.864371860493626 0.203818371843164 no 719 0.193691822929963 886 675442
SGTC_851 0394-0702 453 µM 0.863353261242688 0.204100862363914 no 720 0.193971634349009 1007 762646
SGTC_1399 3562-5772 25 µM 0.860663076222061 0.204848058199819 no 721 0.194711817457109 877 23847490
SGTC_450 aminopyrene 156 nM 0.860090659862717 0.205007255819682 no 722 0.194869534713475 943 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3214 9129694 49.47 µM 0.858994408142831 0.205312345166153 no 723 0.195171800549646 923 17158655
SGTC_2418 pentamidine 31.67 µM 0.858738954674546 0.205383477174451 no 724 0.195242276798031 926 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.858383297573599 0.205482535643907 no 725 0.195340423658079 959 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1847 st056231 15 µM 0.858232128440093 0.2055246482241 no 726 0.195382149251885 1040 5393180
SGTC_1221 2958-7315 257 µM 0.856929291312164 0.205887803926587 no 727 0.195741981765297 914 4562705
SGTC_3206 9114350 49.47 µM 0.855914296974581 0.206170989320214 no 728 0.196022593117387 882 17087243
SGTC_3351 9150312 21.596 µM 0.8558041898932 0.206201723287606 no 729 0.196053048638765 940 4904905
SGTC_824 1304-0008 100 µM 0.854730624864833 0.206501527639529 no 730 0.196350146171027 958 768245
SGTC_2283 7944793 200 µM 0.854624508029971 0.206531175901487 no 731 0.19637952767319 1000 2970533
SGTC_2749 bexarotene 57.39 µM 0.854469907548855 0.206574374649524 no 732 0.196422338038333 928 82146 An retinoic acid receptor inhibitor.
SGTC_2580 diallyl disulphide 81.36 µM 0.852645012835232 0.207084694356634 no 733 0.196928096311127 909 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2229 7354935 190 µM 0.850786502170656 0.207605180326976 no 734 0.19744398049451 943 318112
SGTC_2310 7668677 200 µM 0.848619637441434 0.208212997489913 no 735 0.198046488128323 944 2197143
SGTC_839 0122-0028 230 µM 0.846790982395407 0.208726761067464 no 736 0.198555817707069 1005 759448
SGTC_3250 9135583 49.47 µM 0.846647081667623 0.208767221893503 no 737 0.198595931433405 959 7699353
SGTC_409 arachidonic acid 100 µM 0.84308411458698 0.209770500900338 no 738 0.199590701182365 989 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1396 3511-0007 98.6 µM 0.842810722153351 0.209847601100909 no 739 0.199667155204295 896 X1396
SGTC_480 am 92016 50 µM 0.839331617985007 0.210830207331776 no 740 0.200641622618006 945 2129 K+ channel blocker.
SGTC_1272 0839-0021 27 µM 0.839187149092317 0.210871068064508 no 741 0.200682148771013 986 5027250
SGTC_362 0310-0100 9.03 µM 0.837606106761409 0.211318544201839 no 742 0.201125980985012 965 790235
SGTC_72 0744-0168 198.391 µM 0.837605235579891 0.211318790922122 no 743 0.201126225706356 951 677577
SGTC_875 0709-0210 25.7 µM 0.832957516086512 0.212637434150479 no 744 0.202434344898093 1075 6251364
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.831257687321142 0.213120904236228 no 745 0.202914036162628 982 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1166 k206-0078 225 µM 0.82973829673617 0.213553595805971 no 746 0.203343381931386 1021 5404595
SGTC_331 k048-0133 24.5 µM 0.82955041223279 0.213607137036096 no 747 0.203396511521156 962 6813582
SGTC_918 glabranin 770.725 nM 0.82775983426121 0.214117788278058 no 748 0.203903262898926 994 124049 Also referred to as licorice root.
SGTC_2948 9070189 9.45 µM 0.826143893965478 0.214579244215246 no 749 0.204361235350226 910 6473636 YDL196W YDL196W
SGTC_44 0929-0055 61.211 µM 0.825033855117493 0.214896567095619 no 750 0.204676185145942 952 1379590
SGTC_423 5-fluorouracil 457 µM 0.824059186611011 0.215175416736965 no 751 0.204952964433131 945 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2347 9049783 174.81 µM 0.824005219984998 0.215190862555675 no 752 0.204968295982406 1029 6467988 YPL169C MEX67
SGTC_2734 clemastine 41.6 µM 0.823453895923132 0.215348694195183 no 753 0.205124962435175 937 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1670 st016595 4.04 µM 0.823096426575671 0.215451065487587 no 754 0.205226580374387 1043 597879
SGTC_1019 4262-0212 3.4 µM 0.822304358372058 0.215677996798579 no 755 0.205451848417127 1106 4677213
SGTC_457 grayanotoxin iii 135 µM 0.821386408561588 0.215941167072005 no 756 0.205713101408821 1018 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_682 0kpi-0099 17 µM 0.820887177158781 0.216084371561068 no 757 0.205855267832411 1023 1714895 YML126C ERG13
SGTC_680 0417-1641 114 µM 0.819932263291577 0.216358441706141 no 758 0.20612736154672 956 2835990
SGTC_1112 tnp00069 1.16933 µM 0.819848219860388 0.216382572668897 no 759 0.206151319136286 1051 145826
SGTC_975 1335-0046 28.5 µM 0.81973110707224 0.216416201265443 no 760 0.206184706296193 1022 16486740
SGTC_1655 st012546 55.1 µM 0.819296155227731 0.216541122896779 no 761 0.206308732825788 960 720985 YLR208W SEC13
SGTC_403 arphamenine a 50 µM 0.817515982852667 0.217052837167535 no 762 0.206816809644861 1010 5487158 An arginine aminopeptidase inhibitor.
SGTC_786 4544-0069 423 µM 0.81644393057211 0.21736133765528 no 763 0.207123139792947 1023 748821 YLR208W SEC13
SGTC_205 1486-1330 71.903 µM 0.816108367680084 0.217457953340763 no 764 0.207219079264299 991 4118834
SGTC_521 r062-0005 13.8 µM 0.815510666509512 0.2176301055986 no 765 0.207390030747455 970 2832033
SGTC_2479 5617353 43.85 µM 0.815191015114186 0.217722205125843 no 766 0.207481490039805 992 2731746
SGTC_1731 st035964 63 µM 0.815145503894162 0.21773531987012 no 767 0.207494513738971 957 6739575
SGTC_1721 st082152 9.2685 µM 0.814981596256836 0.217782556103401 no 768 0.207541422302651 994 5296051
SGTC_97 0535-0701 19.132 µM 0.814885993147588 0.21781011051262 no 769 0.207568785754937 967 2832013 YGL099W LSG1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.814812848904744 0.217831193259994 no 770 0.207589722486306 956 521171
SGTC_1247 0448-0043 5.84 µM 0.81404528613296 0.218052502860118 no 771 0.207809504095752 1027 3089013 YGL099W LSG1
SGTC_755 1995-0008 37.3 µM 0.811273665214523 0.218852716117248 no 772 0.208604264939202 1062 689533
SGTC_2376 9072922 81.32 µM 0.810557408771461 0.219059785718412 no 773 0.208809942091785 1037 17087968
SGTC_2425 5628681 7.85 µM 0.810554420136666 0.21906064996813 no 774 0.208810800545696 1064 5714958
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.810550206503594 0.219061868464667 no 775 0.20881201087101 957 61125 An anti-inflammatory.
SGTC_1021 4476-0760 85.3 µM 0.809416286563775 0.219389916554427 no 776 0.209137868609306 1022 746768
SGTC_1257 0669-0121 16 µM 0.80915041951566 0.219466873906907 no 777 0.209214314872931 1110 4307855
SGTC_2142 5622915 118.518 µM 0.807733325958089 0.219877324554515 no 778 0.209622057259545 1010 5322196
SGTC_3023 9089636 49.47 µM 0.801989506290094 0.221545484167218 no 779 0.21127951420885 1126 17249241
SGTC_415 dibenzyl ketone 100 µM 0.801852585133977 0.221585337828254 no 780 0.211319118126428 1021 7593
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.801393128814922 0.221719101786216 no 781 0.211452045874976 1061 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1962 st076595 64.5 µM 0.800977619201207 0.22184011102347 no 782 0.21157230132305 1050 279619
SGTC_2029 5175081 200 µM 0.799456613579676 0.222283396495842 no 783 0.21201284725121 1102 1380876
SGTC_2778 tioconazole 65.09 nM 0.798674793626054 0.222511448458338 no 784 0.212239503134342 1009 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1149 3909-7961 23.3 µM 0.798607534113329 0.222531073865732 no 785 0.212259008821537 1019 735261
SGTC_2176 5809774 33.9695 µM 0.798493664113553 0.222564301826639 no 786 0.212292034235388 1061 2870539
SGTC_2681 menadione 3.18 µM 0.797725372617036 0.222788567893286 no 787 0.212514938254248 1050 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_442 cape 100 µM 0.797507958151124 0.222852055047827 no 788 0.212578041411667 1003 5281787
SGTC_1633 st005664 67.9 µM 0.795737049220803 0.223369561573658 no 789 0.213092443856695 1093 2063822
SGTC_1649 st011737 51.3 µM 0.790714086804751 0.224841118888413 no 790 0.214555426939323 1016 1761035
SGTC_831 k061-1017 217 µM 0.790159509166825 0.225003927535734 no 791 0.214717309818783 1138 1240153
SGTC_1000 4048-0884 8.67 µM 0.789121056409685 0.225308968136998 no 792 0.215020628107695 1004 13040088
SGTC_1447 4239-0816 81.9 µM 0.787883769820715 0.225672720789129 no 793 0.215382347749326 995 1341554
SGTC_1128 3448-9350 235 µM 0.78709914111705 0.225903567592444 no 794 0.215611916069769 954 619386
SGTC_2850 9015429 58.44 µM 0.786902992333836 0.225961297679359 no 795 0.215669327854776 1048 6457570
SGTC_1418 3966-3099 2.4 µM 0.785461644048621 0.226385767946447 no 796 0.216091475185777 1072 740335
SGTC_3043 9092303 49.47 µM 0.785215159795164 0.226458401459374 no 797 0.216163714280246 1035 25236084
SGTC_1648 st011736 69.8 µM 0.785203235997507 0.22646191547513 no 798 0.216167209236752 1056 2855514
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.78429684278467 0.226729125184331 no 799 0.216432975805692 1118 66535 A nucleotide analog.
SGTC_548 1436-0017 110 µM 0.783833883835059 0.226865676645849 no 800 0.21656879446449 1127 9677137
SGTC_598 3937-0236 20.2 µM 0.78324662012113 0.22703895898754 no 801 0.216741151441551 1092 1379313
SGTC_464 bw-b 70c 158 µM 0.782359388442587 0.227300893564955 no 802 0.217001696893061 1096 5353454
SGTC_1339 1486-1321 22.7 µM 0.781568368286306 0.22753456743428 no 803 0.217234141315366 1041 3469382
SGTC_2978 9011784 42.97 µM 0.781482286056666 0.227560004993388 no 804 0.217259445595234 1140 2994934
SGTC_840 0245-0196 390 µM 0.781263396764316 0.227624694653605 no 805 0.217323796808948 1104 3827528
SGTC_3248 9135562 49.47 µM 0.779978571239689 0.228004615497034 no 806 0.21770174423038 1084 17650701
SGTC_3212 9128307 49.47 µM 0.779895299091045 0.228029251239033 no 807 0.217726252848079 953 27243542
SGTC_3309 9129340 25.759 µM 0.779603836120079 0.228115491217631 no 808 0.217812048621098 1091 17158987
SGTC_2474 5321570 43.32 µM 0.778296000100723 0.228502688034713 no 809 0.218197266505608 1065 2841384
SGTC_2925 9010536 32.5 µM 0.778291444395479 0.228504037437893 no 810 0.218198609056232 1079 2994177
SGTC_2994 9053520 71.4286 µM 0.778216340311404 0.228526283967008 no 811 0.218220742656882 1062 4647384
SGTC_473 2-arachidonoylglycerol 10 µM 0.777604965985635 0.228707423991876 no 812 0.218400966271726 991 5282280 An endocannabinoid.
SGTC_2784 7567673 72.73 µM 0.777216016028867 0.228822705328218 no 813 0.218515667257451 1099 3471247
SGTC_1713 st033146 12.748 µM 0.776653550810486 0.228989472732033 no 814 0.218681599069122 1071 674619
SGTC_2028 5153890 36.43 µM 0.775029974799841 0.229471235140632 no 815 0.219160973800645 1061 2830968 YPR165W RHO1
SGTC_2197 6588183 93.1375 µM 0.773982312978071 0.229782408260851 no 816 0.219470625367882 1054 884136
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.77371714163404 0.229861206048592 no 817 0.219549040424976 1066 364106
SGTC_970 1315-0089 19.5 µM 0.772882634938503 0.230109285083961 no 818 0.219795921282734 1058 6811083 YLR033W RSC58
SGTC_1411 3909-8223 150 µM 0.771402436568598 0.230549681201907 no 819 0.220234215657734 1133 X1411
SGTC_3348 9149464 3.537 µM 0.769476482372228 0.231123405368395 no 820 0.220805250218159 1103 1951442
SGTC_1768 st044301 37.178 µM 0.768775228371185 0.231332500223161 no 821 0.221013378437753 1134 3931349
SGTC_2032 5185112 25.99 µM 0.7681516773827 0.231518514738645 no 822 0.221198539112553 1035 5718189
SGTC_2009 4012297 12.05 µM 0.767400487573295 0.231742716501179 no 823 0.22142171936743 1036 45595307
SGTC_1669 st015249 58.4 µM 0.7665408711287 0.231999427868221 no 824 0.221677271323038 1182 722793
SGTC_2800 7887935 81.82 µM 0.766070931263269 0.232139835168979 no 825 0.221817049097544 1050 2961002
SGTC_514 4466-0038 2.65 nM 0.765235769825198 0.232389479011612 no 826 0.22206558168494 1077 5722064
SGTC_1482 3346-2049 8.48 µM 0.764745852625478 0.232535992992699 no 827 0.222211448267914 1076 3826804
SGTC_1720 st037298 9.481 µM 0.763657364428095 0.232861698564477 no 828 0.222535727325723 1058 597396
SGTC_1594 piperine 70.1 µM 0.761335961092126 0.233557172124048 no 829 0.223228213283604 1073 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2143 5623677 140.463 µM 0.761106670890871 0.233625928055089 no 830 0.223296678167883 1086 5375313
SGTC_3098 9119039 49.47 µM 0.760749141494689 0.233733160724097 no 831 0.223403458463462 1141 17161528
SGTC_1643 st009866 20.2 µM 0.760522277115266 0.233801217590845 no 832 0.22347122920196 1111 3156273 YOR207C RET1
SGTC_799 1310-0557 151 µM 0.7597114756885 0.2340445390163 no 833 0.223713533846603 1082 5354492
SGTC_2234 tolnaftate 200 µM 0.758679903868776 0.234354316249508 no 834 0.224022030611551 1073 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_892 0929-0076 29 µM 0.758074909891369 0.234536099232074 no 835 0.224203069492119 1128 5751038
SGTC_1674 st016616 23.6 µM 0.757145236271393 0.234815590899988 no 836 0.224481427621086 1118 625830
SGTC_1361 1608-0041 5.61 µM 0.756634704575436 0.234969152454627 no 837 0.224634371794053 1105 X1361
SGTC_2262 9014885 67.46 µM 0.755954956650106 0.235173698232007 no 838 0.224838101176091 1061 6457424
SGTC_2812 7970281 58.44 µM 0.753125707141591 0.236026114979859 no 839 0.225687188920314 1109 2233435
SGTC_666 0272-0154 136 µM 0.749636702259234 0.23707964772657 no 840 0.226736769829214 1122 6870312
SGTC_1265 0819-1001 68.8 µM 0.748722091193906 0.237356248674372 no 841 0.227012362922163 1113 3106768
SGTC_221 trifluoperazine 10.304 µM 0.747245595135236 0.237803151195732 no 842 0.227457663069755 1177 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2387 9077560 195.08 µM 0.74677441222806 0.237945864858725 no 843 0.227599871791023 1106 5303272
SGTC_3038 9091290 49.47 µM 0.746473678461093 0.238036976784239 no 844 0.227690663058772 1114 25236843
SGTC_2895 9054447 58.44 µM 0.745894860804765 0.23821239231503 no 845 0.227865464984137 1140 2697450
SGTC_410 α-linolenic acid 100 µM 0.745567753304384 0.238311556290658 no 846 0.22796428426517 1129 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1223 0764-0573 147 µM 0.742527723088049 0.239234234521889 no 847 0.228883830670226 1176 1609797
SGTC_1618 st003135 44.5 µM 0.741679182585141 0.239492122684911 no 848 0.229140867788672 1093 1270615
SGTC_1137 ixabepilone 100 µM 0.741532407714292 0.239536745851102 no 849 0.229185344771285 1116 154225 A novel microtubule stabilizer.
SGTC_2697 mebhydrolin 72.4 µM 0.740781440299874 0.23976512940313 no 850 0.229412985110628 1124 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1700 st030840 7.9285 µM 0.739234236072243 0.240236038112145 no 851 0.229882387549216 1129 5499307
SGTC_1104 tacrolimus 29.8 µM 0.739041493933451 0.240294736595916 no 852 0.229940900745218 1154 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3297 9117502 71.43 µM 0.73817189102553 0.24055966617851 no 853 0.230205000848181 1138 7453720
SGTC_55 0767-0285 6.563 µM 0.737137076033285 0.240875135695798 no 854 0.230519497149697 1122 3116166
SGTC_1174 0739-0097 51.1 µM 0.735361592609768 0.241416926332101 no 855 0.231059653092917 1127 728447
SGTC_6 0844-0013 19.835 µM 0.73375664706826 0.241907246253699 no 856 0.23154853353828 1267 1584900
SGTC_654 1124-0271 80.9 µM 0.733612306533405 0.241951369565047 no 857 0.231592529169732 1130 5403748
SGTC_607 4491-0986 66.8 µM 0.731979398885102 0.242450835360747 no 858 0.232090571001213 1156 698981 YDR232W HEM1
SGTC_1590 st077108 57.8 µM 0.730634725611853 0.242862556425273 no 859 0.232501147704646 1123 5489485
SGTC_2584 androsterone 48.74 µM 0.730550283798774 0.242888424003958 no 860 0.232526944272579 1220 2754130 A steroid.
SGTC_58 0957-0393 9 µM 0.729598426918167 0.243180115250784 no 861 0.232817842029598 1143 6997992
SGTC_816 0325-0417 81.3 µM 0.728711052113301 0.243452216812927 no 862 0.233089215388493 1142 68101
SGTC_1407 3909-7909 12.3 µM 0.728373229096383 0.243555848915907 no 863 0.233192573190976 1156 4411780
SGTC_1895 st058434 18.3 µM 0.72786784247544 0.243710928054587 no 864 0.233347244986987 1168 5393175
SGTC_2731 amoxapine 43.43 µM 0.727214811180281 0.243911391247066 no 865 0.23354718718616 1170 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1044 1222-0021 1.78 µM 0.727149727371948 0.243931375114955 no 866 0.233567119460392 1084 4306703
SGTC_2839 9003951 25.97 µM 0.72607481105663 0.244261554007456 no 867 0.233896454911813 1142 2990634
SGTC_2804 7954240 19.48 µM 0.725796198794641 0.24434717381789 no 868 0.233981858777025 1128 828705
SGTC_590 k048-0076 22.4 µM 0.721023831029317 0.245816269416082 no 869 0.235447426304473 1139 6832814
SGTC_2072 5231554 129 µM 0.720338714864651 0.24602755976165 no 870 0.235658236697059 1224 789545
SGTC_2491 paeonol 100 µM 0.719714642362139 0.246220108960955 no 871 0.235850354511662 1114 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2955 9076254 12.21 µM 0.719707974990454 0.24622216652521 no 872 0.235852407497039 1109 16459619
SGTC_1979 st071809 45.3 µM 0.719668444368626 0.246234365943647 no 873 0.235864579780441 1174 4976333
SGTC_1287 0971-0001 34.6 µM 0.719336750906128 0.246336741566693 no 874 0.235966728594077 1154 4665869
SGTC_677 0929-0063 136 µM 0.715820586847016 0.247423390499581 no 875 0.237051069435939 1114 1539583
SGTC_1389 3405-0187 19 µM 0.715369639854437 0.247562938008978 no 876 0.23719033366805 1122 799890
SGTC_2683 piperine 63.03 µM 0.71243537580578 0.248471984780774 no 877 0.238097607982891 1126 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_20 0481-0013 4.944 µM 0.710983615180835 0.248922402922679 no 878 0.238547194605167 1166 182045
SGTC_319 1348-1596 45.5 µM 0.709173088737769 0.249484738826353 no 879 0.239108535681854 1196 5380505
SGTC_82 0054-0107 293.755 µM 0.708745783300389 0.24961755507715 no 880 0.239241123975361 1183 3104697
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.708131710857696 0.249808488513557 no 881 0.239431734390906 1178 688798
SGTC_2463 5473429 200 µM 0.70731171467283 0.250063570633027 no 882 0.239686393577765 1126 5399405
SGTC_2849 9019321 12.99 µM 0.705661920510062 0.250577202396437 no 883 0.24019920357846 1143 16489627
SGTC_2399 5884133 200 µM 0.70369569435792 0.251190078421895 no 884 0.240811151143362 1204 722445
SGTC_2854 9024559 71.43 µM 0.703656957466962 0.251202160734602 no 885 0.240823215720884 1166 3163529
SGTC_1252 0493-0875 34.8 µM 0.703407499908968 0.251279975689076 no 886 0.240900916979804 1199 3960963
SGTC_2168 5727979 200 µM 0.703039771979485 0.251394706743976 no 887 0.241015482062067 1133 695210
SGTC_54 0159-0055 9 µM 0.701150746935632 0.25198451843891 no 888 0.241604471728871 1205 3319099
SGTC_1327 1436-0082 2.18 µM 0.700303265945371 0.252249365148373 no 889 0.241868966290839 1150 15992205
SGTC_3135 9127742 49.47 µM 0.699000990660215 0.252656625743805 no 890 0.242275705864853 1156 3643468
SGTC_73 0327-0325 16.231 µM 0.698178176875846 0.252914122745403 no 891 0.242532886232846 1228 53298
SGTC_368 fentichlor 4.58 µM 0.698176154478693 0.252914755818385 no 892 0.242533518539562 1158 7329 A pesticide.
SGTC_2515 chrysin 20.77 µM 0.697823641966198 0.253025115899893 no 893 0.24264374595594 1187 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1864 st057645 30.4 µM 0.697483553031952 0.253131610575708 no 894 0.242750114335483 1228 688666
SGTC_2980 9014342 25.29 µM 0.696891980970317 0.253316910262729 no 895 0.24293519829784 1199 2996599
SGTC_643 k048-0106 28.4 µM 0.696489182320601 0.253443120748228 no 896 0.243061264778064 1195 6763920
SGTC_2835 9006588 71.43 µM 0.696394550943517 0.253472776762927 no 897 0.243090887299535 1188 2345538
SGTC_2340 7987427 183.45 µM 0.696326238057508 0.253494186101491 no 898 0.243112272539948 1152 2239331
SGTC_2249 haloperidol 116.36 µM 0.69508852664729 0.253882250813749 no 899 0.243499912266838 1210 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1481 3346-2004 36 µM 0.695029751188275 0.253900686675331 no 900 0.243518328495484 1214 2770522
SGTC_2052 5265182 7.135 µM 0.694007408346008 0.254221473204895 no 901 0.243838781486607 1187 1239884
SGTC_2336 9001819 198.65 µM 0.693294881108488 0.254445172677649 no 902 0.244062257400413 1247 2989602
SGTC_1063 disulfiram 1.84 µM 0.693238676659813 0.25446282257444 no 903 0.244079889974028 1208 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1136 pergolide 1.05886 µM 0.691194619171153 0.255105154121613 no 904 0.24472162244746 1171 47811 A dopamine receptor agonist.
SGTC_2343 7990716 14.84 µM 0.690897643230633 0.255198547353778 no 905 0.244814933654067 1190 6456862
SGTC_2648 atorvastatin 78.68 µM 0.688435564983705 0.255973511682394 no 906 0.245589266961023 1220 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.686009508811315 0.256738336984026 no 907 0.246353556101221 1224 5282362
SGTC_1843 st055809 45.5 µM 0.685570497819212 0.256876864215057 no 908 0.246491995399494 1199 16413835
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.683892329663482 0.257406758206216 no 909 0.247021578950038 1049 4000243
SGTC_782 0083-0095 30.5 µM 0.683825324747705 0.257427927288319 no 910 0.247042736482893 1234 3591729 An indicator and reagent.
SGTC_761 k216-0224 480 µM 0.683812529893711 0.257431969711221 no 911 0.247046776707808 1260 1340404
SGTC_1675 st018485 24.5 µM 0.682324560402979 0.25790230557841 no 912 0.24751687312214 1213 3323024
SGTC_1122 capsaicin 818.572 nM 0.681621188682192 0.258124791133771 no 913 0.247739256644738 1243 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2505 galangin 7.89 µM 0.678343659209665 0.259162826790751 no 914 0.248776911382381 1147 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_117 lucigenin 22.078 µM 0.678006319839569 0.259269788851518 no 915 0.248883843077002 1215 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1284 0929-0043 16 µM 0.676341962697329 0.259797849530466 no 916 0.249411778104737 1205 1239883
SGTC_880 0833-0487 87.2 µM 0.673988720512123 0.260545422852061 no 917 0.250159242394743 1210 76075
SGTC_1316 1272-0050 65.9 µM 0.672685906098533 0.260959774156516 no 918 0.250573567935964 1227 7340392
SGTC_3050 9093513 49.47 µM 0.672327704913188 0.261073756980347 no 919 0.250687548000537 1240 25236664
SGTC_2963 9082507 9 µM 0.67188017375205 0.261216201355984 no 920 0.250829991550228 1241 16459611
SGTC_835 0312-0010 67.2 µM 0.671422483969301 0.261361920406507 no 921 0.25097571276852 1203 1626196
SGTC_804 1595-0054 20.9 µM 0.670344017017547 0.261705447214594 no 922 0.251319256733548 1232 761523 Stimulates phospholipase C.
SGTC_1970 st070122 35.8 µM 0.669108321696586 0.262099340980528 no 923 0.25171319096271 1271 102928
SGTC_1183 1254-0324 198 µM 0.668726095596963 0.26222124196083 no 924 0.251835108959925 1255 5799357
SGTC_47 0149-0135 24.25 µM 0.666086539791661 0.26306385115551 no 925 0.252677893750759 1194 5239155
SGTC_1571 st070080 73.4 µM 0.665273399804305 0.26332370334733 no 926 0.252937820490544 1284 4315245
SGTC_2045 5106652 78.05 µM 0.664740234555129 0.263494156147725 no 927 0.253108327403114 1230 673349
SGTC_1708 st033234 31.827 µM 0.664311067817534 0.263631401546179 no 928 0.253245619369697 1307 674664
SGTC_3108 9121785 49.47 µM 0.664240890391196 0.263653847408717 no 929 0.253268073102577 1215 17140271
SGTC_511 blebbistatin 171 µM 0.663981597795742 0.263736789169283 no 930 0.253351044565561 1297 3476986 A myosin inhibitor.
SGTC_1676 st018489 23.4 µM 0.662372052683129 0.264251943291067 no 931 0.253866405003247 1261 3696235
SGTC_1557 sumaresinolic acid 42.3 µM 0.660059961428657 0.264992851350086 no 932 0.254607675599961 1205 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_739 1486-1183 203 µM 0.65595054881669 0.266312309920303 no 933 0.255927971279845 1248 4346692
SGTC_1152 3909-8331 15.9 µM 0.655659801941137 0.266405789306457 no 934 0.256021519244521 1234 16001939
SGTC_2773 thioridazine 9.09 µM 0.653954437399998 0.266954423075059 no 935 0.256570580158387 1268 5452 An antipsychotic.
SGTC_476 mead acid 10 µM 0.651376271590401 0.26778492835846 no 936 0.257401812022322 1286 5312531 An omega 9 fatty acid.
SGTC_1295 1013-0063 9.78 µM 0.650955243010109 0.267920677959694 no 937 0.257537689524269 1270 6826038
SGTC_2671 danthron 100 µM 0.648552250529935 0.268696122513379 no 938 0.258313913780509 1227 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3216 9129716 49.47 µM 0.648417485435115 0.268739644516672 no 939 0.258357482017644 1226 8056934
SGTC_275 trichlorophene 5.69 µM 0.647206183346268 0.269130989970545 no 940 0.258749254986691 1311 62616
SGTC_12 0849-0099 9.267 µM 0.647035071247079 0.269186295622285 no 941 0.258804622764995 1211 6071388
SGTC_1500 4488-1866 171 µM 0.645810220833152 0.269582349579776 no 942 0.259201133976237 1328 2900003
SGTC_749 1000-0129 128 µM 0.645735962898616 0.269606370180471 no 943 0.259225183006114 1335 708470
SGTC_150 3970-0969 77.2 µM 0.644944443783948 0.269862473602763 no 944 0.259481594484488 1315 6615640
SGTC_1730 st033808 45.1 µM 0.643339063591163 0.270382283135192 no 945 0.260002057064091 1284 1045166
SGTC_888 0916-0002 6.97 µM 0.64240199111525 0.270685931006749 no 946 0.260306103614491 1324 2802138 YIL048W NEO1
SGTC_3081 9117243 49.47 µM 0.642259834207951 0.270732010236352 no 947 0.260352244451544 1335 45595589
SGTC_2862 9027634 71.43 µM 0.642080434825155 0.27079016695959 no 948 0.260410479345897 1227 5012562
SGTC_762 1165-0429 115 µM 0.637983148715936 0.272120098324937 no 949 0.26174232479551 1306 5967793
SGTC_1712 st032288 53.4 µM 0.636156824923872 0.27271394625509 no 950 0.262337105437562 1269 2883011
SGTC_3337 9144342 33.5465 µM 0.635424989818545 0.27295209029489 no 951 0.262575636999607 1312 17682949
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.635382284677902 0.272965990016806 no 952 0.262589559578157 1265 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1972 st070201 17.4 µM 0.63484340938367 0.273141413962013 no 953 0.26276527424607 1289 2829099
SGTC_914 3820-6779 408 µM 0.633519129407228 0.273572753536826 no 954 0.263197346426492 1267 2893481
SGTC_2115 tiliquinol 12.7705 µM 0.633397211489185 0.27361248112905 no 955 0.263237142762778 1293 71208 A bioactive hydroxyquinoline.
SGTC_2914 7968218 45.32 µM 0.632774858497382 0.273815322579647 no 956 0.263440338540382 1279 2977111
SGTC_441 propafenone 146 µM 0.632605337458817 0.273870586893836 no 957 0.263495700357059 1250 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2966 9084041 48.03 µM 0.63252509122564 0.273896749304502 no 958 0.263521909070086 1210 17741380
SGTC_700 3453-2283 142 µM 0.631847705141168 0.27411764444415 no 959 0.26374319884291 1354 565664
SGTC_2973 9094665 17.96 µM 0.63170370075016 0.274164615519042 no 960 0.263790254683262 1329 25237061 YIL048W NEO1
SGTC_3247 9135149 49.47 µM 0.63132602956396 0.274287822462121 no 961 0.263913685386357 1263 8934436 YOR116C RPO31
SGTC_877 0771-0151 33.1 µM 0.631091201241149 0.274364443834783 no 962 0.263990446947835 1336 6166523
SGTC_2056 5235370 200 µM 0.629947742224819 0.274737690289216 no 963 0.264364387638648 1288 5511916
SGTC_2666 tannic acid 100 µM 0.629786714646861 0.274790272812771 no 964 0.264417069475554 1316 16134267 A thiamine antagonist.
SGTC_2441 5730946 39.09 µM 0.629698777019029 0.274818990375876 no 965 0.264445841435278 1322 1774275
SGTC_2990 9074105 71.4286 µM 0.629462993796948 0.274895996791652 no 966 0.264522994264679 1266 6502001
SGTC_144 4161-2749 112.381 µM 0.628715221560188 0.275140288301995 no 967 0.264767755536631 1224 797501 YMR168C CEP3
SGTC_1336 1486-0901 104 µM 0.627147036072154 0.275652949513675 no 968 0.265281428673825 1319 5006114
SGTC_1719 st032227 49.2 µM 0.626862670979225 0.275745962613898 no 969 0.265374629153893 1306 3125804
SGTC_2820 7989630 71.43 µM 0.626708677441365 0.275796338863969 no 970 0.265425107374346 1210 2984098
SGTC_1587 estradiol valerate 56.1 µM 0.62605659065905 0.276009707578908 no 971 0.26563891175945 1286 13791 A steroid.
SGTC_3168 9103419 49.47 µM 0.625987589184779 0.276032290229512 no 972 0.265661540878008 1255 16649256
SGTC_1269 0831-0796 3.05 µM 0.624798675511099 0.276421537710601 no 973 0.266051600044222 1288 927758
SGTC_864 0469-0573 172 µM 0.624444293309324 0.276537613648834 no 974 0.266167921957372 1262 689425
SGTC_506 n9-isopropylolomoucine 153 µM 0.621895431203678 0.277373182707944 no 975 0.26700531476791 1332 6610355
SGTC_2134 5324836 1.464 µM 0.619931377641753 0.278017880536809 no 976 0.2676514833292 1315 699272
SGTC_2904 7225135 42.03 µM 0.619884606879494 0.27803324188232 no 977 0.2676668803922 1372 4446116
SGTC_2662 daunorubicin 22.37 µM 0.619432188004587 0.278181855288537 no 978 0.26781584096545 1270 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1131 3454-3128 32.3 µM 0.618864850854737 0.278368272505439 no 979 0.268002697805331 1413 710982
SGTC_2488 5268135 45.7 µM 0.617259286341631 0.278896163075314 no 980 0.26853185827723 1351 1270356 YLR208W SEC13
SGTC_1953 st076800 12.1 µM 0.615464756744513 0.279486758951101 no 981 0.269123918594208 1281 297591
SGTC_395 anisomycin 6.25 µM 0.614719841386901 0.279732095566934 no 982 0.269369877084297 1269 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_987 1497-1013 404 µM 0.611627972712911 0.280751512818602 no 983 0.270391963205017 1310 1676435
SGTC_2727 riluzole 51.77 µM 0.610941791277053 0.280977996456101 no 984 0.270619058317521 1322 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2358 9037157 4 µM 0.608788811523256 0.281689189662714 no 985 0.271332215320118 1363 2388925
SGTC_1819 st053448 58.6 µM 0.60844370998283 0.281803267615138 no 986 0.271446614428042 1318 2857616
SGTC_1331 1472-0049 76.2 µM 0.606041534241551 0.28259795538814 no 987 0.272243586533291 1297 24051409
SGTC_443 clozapine 122 µM 0.604482634650071 0.283114246259435 no 988 0.272761405537492 1265 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1113 artemisinin 1.17947 µM 0.604137101743194 0.283228744314204 no 989 0.272876247177749 1349 2240 An anti-malaria and mitochondrial poison.
SGTC_1491 4138-0063 26.5 µM 0.602558130928265 0.283752244933793 no 990 0.273401340371363 1313 23883227
SGTC_118 0083-0097 135.343 µM 0.599027894135084 0.284924352089298 no 991 0.274577141776364 1403 5207356
SGTC_3162 9099653 49.47 µM 0.598859682693172 0.284980259146306 no 992 0.274633229469011 1322 25237511
SGTC_3181 9108277 49.47 µM 0.598494724609474 0.285101575255757 no 993 0.27475493893447 1289 17097298
SGTC_2268 7933382 153.85 µM 0.597021405685441 0.285591572919833 no 994 0.275246544629709 1342 935025 YOR257W CDC31
SGTC_2653 dihydrofissinolide 100 µM 0.595035059450242 0.286252827376633 no 995 0.275910017988989 1358 6857746
SGTC_2690 usnic acid 100 µM 0.594644614582254 0.286382891882742 no 996 0.276040525531619 1447 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3207 9114163 49.47 µM 0.59247292988353 0.287106832195366 no 997 0.276766971302339 1481 849233
SGTC_1926 methyl fluorone black 53.6 µM 0.591300195613519 0.287498128106157 no 998 0.277159649272727 1242 72721 Reacts with homocysteine.
SGTC_870 0573-2213 57.6 µM 0.59096608225944 0.28760965490392 no 999 0.277271573554679 1336 3916321
SGTC_2618 avocadyne 43.43 µM 0.58878599421103 0.288337868306545 no 1000 0.278002421194941 1325 3015189
SGTC_1031 k035-0009 16 µM 0.586973762507193 0.288943867811139 no 1001 0.278610664121155 1393 5180959
SGTC_406 estrone 100 µM 0.586050150807245 0.289252948442601 no 1002 0.278920906869737 1437 5870 A steroid.
SGTC_2203 7227154 166.4 µM 0.585913429042129 0.289298714691078 no 1003 0.278966846221489 1347 896304
SGTC_215 1287-0124 461.5 µM 0.585275684817305 0.289512238161532 no 1004 0.279181180804168 1412 5560863
SGTC_2323 6148992 148.28 µM 0.585251250082666 0.289520420639472 no 1005 0.279189394479384 1322 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2446 5162541 200 µM 0.585173117118567 0.289546585812655 no 1006 0.279215659469026 1334 1549321
SGTC_1873 rapamycin 2 nM 0.583397805731836 0.290141401245069 no 1007 0.279812767316287 1371 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_364 0083-0097 67.7 µM 0.583346249523611 0.290158683628167 no 1008 0.279830116971604 1397 5207356
SGTC_2238 6671620 73.2395 µM 0.580540590078472 0.291099907589807 no 1009 0.280775061347798 1324 729941
SGTC_2561 acetosyringone 100 µM 0.579498663191108 0.291449809036159 no 1010 0.281126374187359 1345 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_965 1291-5240 308 µM 0.578966982027426 0.29162843456839 no 1011 0.281305726145314 1423 2834598
SGTC_961 1252-1571 372 µM 0.577999614801843 0.291953565610213 no 1012 0.281632189647857 1443 6813498
SGTC_713 1488-1073 324 µM 0.577185527666948 0.292227310110655 no 1013 0.28190706624652 1352 3312542
SGTC_588 3970-1144 52.9 µM 0.576972662295406 0.29229890779388 no 1014 0.281978961570818 1350 1888707
SGTC_780 0109-0199 192 µM 0.572840114776721 0.293690512065518 no 1015 0.283376477552703 1485 610414
SGTC_2555 cholic acid 100 µM 0.571959646499896 0.293987398924654 no 1016 0.283674656718127 1370 6708657 Influences liver metabolism.
SGTC_565 1418-0001 44.5 µM 0.563868340657694 0.296722195859356 no 1017 0.286421868772652 1430 2862145
SGTC_2906 7926292 26.41 µM 0.563508596916826 0.296844056393705 no 1018 0.286544303869172 1377 2966319
SGTC_2724 maprotiline 69.64 µM 0.562611808459094 0.297147936531915 no 1019 0.286849624675897 1407 4011 A tricyclic antidepressant.
SGTC_2317 5986382 200 µM 0.562376681535629 0.297227633699424 no 1020 0.286929701545678 1483 877883
SGTC_2070 5230947 200 µM 0.55994741748765 0.29805161326437 no 1021 0.287757652157444 1443 2835538
SGTC_33 0986-0033 35.816 µM 0.558357644348179 0.298591409628181 no 1022 0.288300094730369 1391 2848082
SGTC_2595 hexamethylquercetagetin 100 µM 0.557446281898154 0.298901056744374 no 1023 0.288611275756488 1400 386331
SGTC_2099 5377090 177.372 µM 0.553925193346265 0.300098760051909 no 1024 0.289815021297318 1380 2243829
SGTC_1381 2324-0066 62.1 µM 0.552189122285787 0.300690084984137 no 1025 0.290409393125895 1422 10885928
SGTC_1118 chelidonine 707.474 nM 0.551072091645786 0.301070835738516 no 1026 0.290792127993074 1461 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1423 4048-0112 5.59 µM 0.550983219243072 0.301101138090709 no 1027 0.290822588999618 1448 X1423
SGTC_1691 st019933 84.6 µM 0.549203671961982 0.301708189950057 no 1028 0.291432842380732 1430 6176082
SGTC_2728 chlorpromazine 9.18 µM 0.548115850551157 0.302079546146742 no 1029 0.29180617879758 1416 2726 A thorazine and dopamine antagonist.
SGTC_197 4544-0043 41.561 µM 0.547841431069165 0.30217325879843 no 1030 0.291900393765215 1405 896523
SGTC_549 1661-1316 519 µM 0.547414802135097 0.302318975996978 no 1031 0.29204689411455 1488 2857282
SGTC_1289 0976-0073 69.1 µM 0.546500143196442 0.302631488419042 no 1032 0.292361094657878 1449 3391136
SGTC_1101 ebselen 5.29 µM 0.545608698120364 0.302936208553373 no 1033 0.292667472021116 1475 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2211 7117706 200 µM 0.543766920991981 0.303566212527734 no 1034 0.293300937292217 1448 822771
SGTC_2188 6126565 140.678 µM 0.543650450094943 0.303606072584477 no 1035 0.293341017928421 1437 874518
SGTC_957 1187-1561 14.1 µM 0.543571336935022 0.303633148964383 no 1036 0.29336824425234 1396 1538454
SGTC_1851 st056236 18.9 µM 0.543166610268166 0.3037716830197 no 1037 0.293507546843772 1450 5393171
SGTC_3029 9088683 49.47 µM 0.543118766084813 0.303788061488529 no 1038 0.293524016324698 1425 25236615
SGTC_733 4069-0007 56.1 µM 0.542359377770022 0.304048075143697 no 1039 0.293785479083604 1450 5717425 YNL287W SEC21
SGTC_2114 5491910 81.25 µM 0.542337156376237 0.304055685216114 no 1040 0.293793131688922 1498 2849228
SGTC_211 3455-0679 143.504 µM 0.541515699383386 0.304337065882733 no 1041 0.294076089809947 1423 748649
SGTC_2517 totarol 10 µM 0.541182842378185 0.304451115229059 no 1042 0.29419078119708 1363 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2300 7976697 71.57 µM 0.539434065440329 0.305050624292038 no 1043 0.294793690450651 1357 2236109
SGTC_1947 st076332 61.6 µM 0.538936011525541 0.305221461102588 no 1044 0.294965503942779 1423 24208416
SGTC_1328 1441-0025 69.2 µM 0.535384621292363 0.306440847287764 no 1045 0.296191961073968 1339 4562601
SGTC_1203 3992-3522 103 µM 0.534747568109704 0.306659809864564 no 1046 0.296412211837887 1660 5322312
SGTC_1874 staurosporine 7.6 µM 0.534180850337669 0.306854655359915 no 1047 0.296608208354172 1512 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_279 1273-0055 2.93 µM 0.531860234807805 0.307653084284078 no 1048 0.29741140020325 1479 2847562
SGTC_199 4063-0024 41.6 µM 0.531722294826683 0.307700572541589 no 1049 0.297459174088795 1480 306215
SGTC_1526 st051518 75 µM 0.531694057176605 0.307710294245145 no 1050 0.297468954297963 1440 673993
SGTC_1184 1269-1718 139 µM 0.530346459941104 0.308174404060071 no 1051 0.29793586994549 1544 5403821
SGTC_342 k048-0088 23.3 µM 0.529352991693483 0.308516749110426 no 1052 0.298280300736243 1395 6820570
SGTC_2383 9036125 200 µM 0.528537400350713 0.308797923016631 no 1053 0.298563197873994 1451 79580
SGTC_905 2-aminofluorene 215 µM 0.527872926743997 0.309027082193585 no 1054 0.298793768279916 1452 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3290 9121031 71.43 µM 0.52707942430981 0.309300837357666 no 1055 0.29906921728105 1412 17014854
SGTC_2325 6158266 200 µM 0.526155821434009 0.309619610009082 no 1056 0.299389973236925 1434 3623240
SGTC_2730 imipramine 71.33 µM 0.525199163959957 0.309949942190537 no 1057 0.299722373028872 1473 3696 A tricyclic antidepressant.
SGTC_3136 9095672 49.47 µM 0.524316115068257 0.310254993691877 no 1058 0.300029345085349 1378 17217380
SGTC_190 3970-0790 3.722 µM 0.523261965152899 0.310619323486902 no 1059 0.300395982690244 1498 2832352
SGTC_16 erodoxin 22.806 µM 0.522614190127498 0.310843296314583 no 1060 0.300621381831248 1465 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_947 3447-0010 211 µM 0.522398006426326 0.310918058974142 no 1061 0.300696621881223 1439 748350
SGTC_2163 5671233 125 µM 0.522290218777976 0.31095533801813 no 1062 0.300734139207228 1567 701023
SGTC_2458 5808907 16.39 µM 0.520614271280944 0.311535224528592 no 1063 0.301317752803638 1466 2731747
SGTC_3048 9093155 49.47 µM 0.520475299968349 0.311583330344399 no 1064 0.301366169540502 1431 25236002
SGTC_1694 st024011 44.9 µM 0.519381096771474 0.311962208135915 no 1065 0.301747505384799 1493 2787533
SGTC_2832 7992762 51.95 µM 0.518446183150125 0.31228608817683 no 1066 0.302073499685516 1320 2985177
SGTC_985 1493-0307 8.71 µM 0.517908345633038 0.312472475794247 no 1067 0.302261109456811 1486 3278274
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.51612026034447 0.313092481570798 no 1068 0.302885209155768 1430 115019
SGTC_526 4469-0568 170 µM 0.515878080531364 0.313176496390385 no 1069 0.302969782097068 1435 2901964
SGTC_2250 alverine citrate 130 µM 0.515022389848952 0.313473422477815 no 1070 0.303268687136905 1434 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1383 3049-0032 20.7 µM 0.514420937672019 0.313682199761492 no 1071 0.303478861878186 1548 712864
SGTC_3176 9106582 49.47 µM 0.512688523492431 0.314283892212202 no 1072 0.304084609442241 1410 17018027
SGTC_925 2064-1272 59.6 µM 0.511552175178301 0.314678830690701 no 1073 0.304482231904514 1442 6815817
SGTC_1296 1068-0102 11.9 µM 0.511537663248438 0.314683875692409 no 1074 0.304487311305939 1504 767053
SGTC_1562 morin hydrate 59.1 µM 0.511176027200339 0.314809607872848 no 1075 0.304613901729717 1487 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_922 1866-0035 480 µM 0.511141529249991 0.314821603104751 no 1076 0.30462597893398 1518 3156169
SGTC_1080 nisoldipine 24.4 µM 0.5108600766248 0.314919473883981 no 1077 0.30472451914448 1451 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.510321726170262 0.315106713098968 no 1078 0.304913042080154 1465 5106787 A p450 inhibitor.
SGTC_1372 2752-0194 270 µM 0.509863629940647 0.315266077177837 no 1079 0.305073501882832 1407 823334
SGTC_1193 1488-0126 41.5 µM 0.50767621089299 0.316027517598299 no 1080 0.305840217158155 1474 1384710
SGTC_2278 7948257 134.34 µM 0.506656263642968 0.31638282839383 no 1081 0.306198011668361 1499 1247028
SGTC_2082 5219693 150 µM 0.506532146508336 0.316426077657929 no 1082 0.306241564223626 1448 2834649
SGTC_3347 9188721 44.724 µM 0.505810813234511 0.316677479687526 no 1083 0.306494733397309 1482 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1415 3966-0071 78.1 µM 0.50562017322539 0.316743936480556 no 1084 0.306561658509532 1463 2893185
SGTC_2962 9082311 13.18 µM 0.505433434437117 0.316809039048861 no 1085 0.306627220333656 1422 16459453
SGTC_2566 crystal violet carbinol 226 nM 0.504999504207992 0.31696034164339 no 1086 0.306779592102045 1377 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1190 1486-1332 13 µM 0.504753422315392 0.317046158970252 no 1087 0.306866016992702 1437 4150046
SGTC_1534 6-azauridine 81.6 µM 0.503315044684555 0.317547968108729 no 1088 0.307371395294042 1470 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2470 5664817 21.68 µM 0.503290758768114 0.317556443657913 no 1089 0.307379931367958 1502 2859561
SGTC_1794 st048918 76.9 µM 0.5031465105005 0.317606786874403 no 1090 0.307430634255615 1462 672303
SGTC_1194 1488-0194 225 µM 0.501312738827837 0.318247074179805 no 1091 0.308075520678173 1481 1391452
SGTC_1695 st026914 34.495 µM 0.500951078478088 0.318373417221403 no 1092 0.308202776623861 1438 3289191
SGTC_1828 st055811 49 µM 0.500867789691211 0.318402516461474 no 1093 0.308232086375022 1497 5877589
SGTC_1910 st062352 60.4 µM 0.500684331857708 0.318466616478736 no 1094 0.308296650439923 1377 2245730
SGTC_2098 5376439 882.5 nM 0.500228793025279 0.318625804871769 no 1095 0.308456993242633 1579 2844116
SGTC_1984 st072354 53.1 µM 0.499848697984302 0.318758654998771 no 1096 0.308590808934328 1488 5762938
SGTC_2005 4024620 188 µM 0.499789913056777 0.318779203480076 no 1097 0.308611506938628 1458 236743
SGTC_1686 st019653 115.5 µM 0.499640504592443 0.318831432249752 no 1098 0.308664115967036 1564 97252
SGTC_1800 st050079 29.0735 µM 0.499338689387731 0.318936948872771 no 1099 0.308770401742391 1435 3645560
SGTC_1163 k060-0048 49.9 µM 0.499334944638918 0.318938258154304 no 1100 0.308771720575557 1474 6809982
SGTC_429 1112-0049 25.5 µM 0.498885112600662 0.319095549963402 no 1101 0.308930161263528 1435 2836170
SGTC_304 1310-0298 97 µM 0.498612756574561 0.319190799948856 no 1102 0.309026108300833 1429 1550234
SGTC_428 3448-4153 16.5 µM 0.497700803327553 0.319509820588669 no 1103 0.309347470899522 1411 3834874
SGTC_2263 7948595 193.29 µM 0.496571618687019 0.319905018544971 no 1104 0.309745585663275 1469 2971371
SGTC_1638 st008370 60.6 µM 0.496405336957739 0.319963231979908 no 1105 0.309804230209118 1441 24207134
SGTC_2092 5303694 80.6725 µM 0.494194350234119 0.320737695450118 no 1106 0.310584464713927 1453 1963699
SGTC_2369 9071472 200 µM 0.492450411590353 0.321349112630147 no 1107 0.311200484638245 1545 17296037
SGTC_2424 5537928 59.2 µM 0.490958003135035 0.32187272921466 no 1108 0.311728075652625 1472 5382802
SGTC_650 1328-0195 38 µM 0.488595752431846 0.322702256067333 no 1109 0.312563960387299 1507 2780821
SGTC_2119 5528445 120.635 µM 0.488501107199738 0.322735510069651 no 1110 0.312597470832418 1554 791935
SGTC_246 cycloheximide 667 µM 0.487050776685301 0.323245267002191 no 1111 0.31311117392911 1445 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_556 4058-0063 51.5 µM 0.486862583645064 0.323311436771038 no 1112 0.313177858013345 1538 6615692
SGTC_302 1094-0063 18.9 µM 0.485512308288912 0.323786365273063 no 1113 0.313656491964115 1452 5440289
SGTC_175 3793-3120 23.7 µM 0.484059130447284 0.324297808107256 no 1114 0.31417195255638 1489 5322297
SGTC_353 1988-1175 58.3 µM 0.483478456015218 0.324502268033296 no 1115 0.314378026607425 1428 2788357
SGTC_2130 NSC 7 2.4545 µM 0.482987054854507 0.324675335492224 no 1116 0.31455246390193 1595 21448
SGTC_2339 9000433 200 µM 0.482490743847004 0.324850170589436 no 1117 0.314728686119406 1460 2988954
SGTC_1853 st056710 91.2 µM 0.481357511640707 0.325249518022289 no 1118 0.315131214329455 1666 269167
SGTC_1027 k015-0025 8.67 µM 0.480710718574592 0.325477535877247 no 1119 0.315361056061566 1464 3598955
SGTC_1944 st076371 56.9 µM 0.47901629777257 0.32607518984602 no 1120 0.315963517182175 1464 24208455
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.477825454134315 0.326495490317617 no 1121 0.316387221322152 1511 6708784 An antioxidant flavonoid
SGTC_1999 st074831 12.5 µM 0.475402093277133 0.327351479745245 no 1122 0.317250201371204 1476 17112523
SGTC_534 k292-0788 63.4 µM 0.475100537741628 0.327458060082134 no 1123 0.31735765761755 1590 4146317
SGTC_797 k781-0471 270 µM 0.474348047079692 0.327724078080902 no 1124 0.317625867135581 1570 23738129
SGTC_289 k017-0060 526 µM 0.473694069141284 0.327955341230193 no 1125 0.317859041632895 1511 5512909
SGTC_2478 5763493 32.33 µM 0.473370383361114 0.328069829130477 no 1126 0.317974477869061 1565 1365576 YLR208W SEC13
SGTC_490 phenamil 164 µM 0.473018559319704 0.328194287877548 no 1127 0.318099969130628 1589 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_174 3553-0389 74.3 µM 0.472755253194506 0.328287445642402 no 1128 0.318193900817336 1549 738071
SGTC_440 fluspirilene 35.1 µM 0.472654262734229 0.32832317892308 no 1129 0.318229931203121 1600 3396 An atypical antipsychotic.
SGTC_859 0439-0102 54.6 µM 0.471788511318447 0.328629570673447 no 1130 0.318538876040747 1563 610143
SGTC_3291 9121177 71.43 µM 0.471353622599468 0.328783522457388 no 1131 0.31869411444155 1496 17015612
SGTC_2321 7390090 138.78 µM 0.469686888633523 0.329373819699604 no 1132 0.319289368321004 1451 649046
SGTC_1879 gemcitabine 100 µM 0.467271773431144 0.330229921426915 no 1133 0.320152724305973 1540 60750 A nucleoside analog which inhibits DNA replication.
SGTC_809 3998-0021 90 µM 0.467038697739409 0.330312588431035 no 1134 0.320236095905323 1534 715485
SGTC_658 3253-0951 102 µM 0.466716349364873 0.33042693221033 no 1135 0.320351415461208 1545 1184878
SGTC_509 pifithrin 175 µM 0.465630111667139 0.330812360193382 no 1136 0.320740142749334 1599 4817 A p53 inhibitor.
SGTC_1710 st031758 61.5 µM 0.464733049958747 0.331130798464574 no 1137 0.321061318711874 1609 5394341
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.462519587516699 0.331917053921647 no 1138 0.321854379527422 1505 803109
SGTC_3355 9151058 44.0485 µM 0.46089816935249 0.332493476581195 no 1139 0.322435832613731 1520 17015728
SGTC_3106 9121286 49.47 µM 0.458632042079316 0.333299760582567 no 1140 0.323249211412592 1589 15943471
SGTC_126 0417-1624 672.48 µM 0.457918418798872 0.3335538262491 no 1141 0.323505526772578 1587 41912 YDL195W SEC31
SGTC_2367 9070478 135.38 µM 0.454068298424269 0.334925869030236 no 1142 0.324889834833741 1546 572802
SGTC_3188 9110789 49.47 µM 0.452379084376783 0.335528540892938 no 1143 0.325497956003322 1615 849217
SGTC_2886 9058944 51.95 µM 0.452289136041368 0.335560644230926 no 1144 0.32553035067152 1503 4949929
SGTC_283 0987-0079 11.7 µM 0.450968347278904 0.336032183275895 no 1145 0.326006181092936 1607 411556
SGTC_3160 9100216 49.47 µM 0.450769603752692 0.336103159705805 no 1146 0.32607780545221 1563 17191039
SGTC_2702 st077768 96.8 µM 0.450651818847574 0.336145226485888 no 1147 0.326120256496664 1513 6484119
SGTC_962 1254-0300 21.5 µM 0.449649486252669 0.336503291719427 no 1148 0.326481599908701 1572 7340576
SGTC_769 0302-0231 76 µM 0.447365199907627 0.337319865530695 no 1149 0.327305699023493 1586 571869 YER009W NTF2
SGTC_651 3253-0966 34.4 µM 0.446876740609101 0.337494576861872 no 1150 0.327482029338616 1530 781462
SGTC_231 b-estradiol 524 µM 0.446818160393178 0.337515532092296 no 1151 0.327503178963556 1507 450 A steroid.
SGTC_2307 7538926 6.34 µM 0.446433177527106 0.337653260142795 no 1152 0.3276421857906 1545 96582
SGTC_2178 5812956 200 µM 0.446273285475357 0.337710468095348 no 1153 0.32769992547875 1566 5403383
SGTC_1759 st043059 70 µM 0.444193990430851 0.338454762395422 no 1154 0.328451168367952 1507 669426
SGTC_781 4335-2806 94.4 µM 0.444134337027324 0.33847612496893 no 1155 0.328472731214571 1685 845254
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.443176758319711 0.338819116078355 no 1156 0.328818944228375 1542 689007
SGTC_986 1493-0483 84 µM 0.441989410565859 0.339244592836442 no 1157 0.329248434395182 1612 40079
SGTC_2291 7917025 104.35 µM 0.440387687746026 0.33981888248238 no 1158 0.329828170381604 1506 2964612
SGTC_3266 9136860 49.47 µM 0.44012926003633 0.339911575320111 no 1159 0.329921745423775 1527 4871271 YPR165W RHO1
SGTC_1634 st006576 41 µM 0.439752331595666 0.340046789347463 no 1160 0.330058247915244 1705 3915356
SGTC_614 0462-0418 107 µM 0.438841047038262 0.340373775779718 no 1161 0.330388357889389 1491 5188303
SGTC_159 3970-0959 50 µM 0.436210625655434 0.341318294225854 no 1162 0.331341959646481 1621 6615653
SGTC_2481 5478948 45.16 µM 0.43540607015539 0.341607388923717 no 1163 0.331633852541748 1554 77792
SGTC_3245 9134821 49.47 µM 0.434924952253722 0.341780309710989 no 1164 0.331808451086006 1495 17014901
SGTC_1239 0337-0584 35.4 µM 0.43346185850802 0.342306370817182 no 1165 0.332339634787076 1721 914301 YML130C ERO1
SGTC_1774 st048371 48.465 µM 0.432489882302049 0.342656017995108 no 1166 0.332692702093086 1536 4242727
SGTC_3336 9143619 71.43 µM 0.432206898362024 0.342757840635664 no 1167 0.332795523034834 1612 45595730
SGTC_1850 st056238 17 µM 0.43121369991147 0.343115301422912 no 1168 0.333156496710738 1548 5393177
SGTC_2466 5983409 37.09 µM 0.429587879181504 0.343700751481398 no 1169 0.333747727820182 1571 2879657
SGTC_1366 1683-0113 21.9 µM 0.428639484417296 0.344042437080308 no 1170 0.334092803237403 1561 708623
SGTC_929 2805-0021 398 µM 0.428575170641306 0.344065612522471 no 1171 0.334116209022073 1635 3098024
SGTC_1978 st071761 42 µM 0.428057355869685 0.344252228194898 no 1172 0.334304681434227 1527 5147680
SGTC_2847 9005661 71.43 µM 0.427891452969833 0.344312026096403 no 1173 0.334365075031687 1569 2991449
SGTC_3001 9076041 71.4286 µM 0.427483716146312 0.344459006949028 no 1174 0.334513521595231 1566 16004211
SGTC_1799 st045822 46.1415 µM 0.427061566214897 0.344611208185109 no 1175 0.334667242867842 1675 3674992
SGTC_1801 st050089 28.441 µM 0.4266963531013 0.344742901813826 no 1176 0.334800253583684 1578 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1521 st012942 49.4 µM 0.424984436329722 0.345360459173655 no 1177 0.33542401022021 1766 24207259
SGTC_160 3453-0671 289.699 µM 0.423922152430643 0.345743875002336 no 1178 0.335811293966802 1515 5322268
SGTC_387 norethindrone acetate 66.7 µM 0.423603646011172 0.345858866092242 no 1179 0.335927447931867 1581 541197
SGTC_3254 9136651 49.47 µM 0.422073064263184 0.34641165365112 no 1180 0.336485843949072 1554 16454030
SGTC_2140 5586273 200 µM 0.421641330204823 0.346567638703554 no 1181 0.336643417053553 1591 854421
SGTC_2743 auranofin 4.32 µM 0.420229556935099 0.347077892403837 no 1182 0.337158882311307 1630 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_386 1509-0011 3.07 µM 0.420215443115526 0.347082994928398 no 1183 0.337164037080902 1592 3107280
SGTC_2378 9074213 121.43 µM 0.419846662394014 0.347216328880292 no 1184 0.337298737155369 1567 657714
SGTC_1624 st003710 6.25 µM 0.417132486518195 0.348198229489124 no 1185 0.33829075202142 1693 24207033
SGTC_889 0919-1524 82.7 µM 0.415010533137865 0.348966593025306 no 1186 0.339067096168413 1567 3905452
SGTC_1442 4112-3290 3 µM 0.413011265851406 0.349691098800496 no 1187 0.339799179868638 1598 704353
SGTC_730 1436-0052 41.2 µM 0.412797107189856 0.34976873935217 no 1188 0.339877635533076 1618 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2954 9074818 52.69 µM 0.411767548095298 0.350142080818378 no 1189 0.340254904735472 1659 16648742
SGTC_783 0848-0141 92.7 µM 0.409008855856808 0.351143158509823 no 1190 0.341266581083735 1575 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1817 st052116 64.4 µM 0.408001534708587 0.351508954515971 no 1191 0.341636274087609 1659 4361398
SGTC_287 k060-0039 29.6 µM 0.406052043552239 0.352217278176879 no 1192 0.342352180610047 1705 5861974
SGTC_1312 1218-2183 165 µM 0.404029699616023 0.352952614120699 no 1193 0.343095439745235 1639 6744073
SGTC_1775 st081588 35.1725 µM 0.40073395389598 0.354152142899859 no 1194 0.344308004782371 1609 1426443 YGL099W LSG1
SGTC_1343 1487-0095 224 µM 0.39561629818324 0.356017647044156 no 1195 0.34619405592087 1734 4560101 YGL055W OLE1
SGTC_2439 5492030 7.2 µM 0.39557341451736 0.356033293781213 no 1196 0.346209876393324 1722 5722370
SGTC_539 4859-0462 2.54 µM 0.394931354919717 0.35626758765897 no 1197 0.346446774556864 1763 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3194 9111903 49.47 µM 0.394773444738828 0.356325218959312 no 1198 0.346505047253192 1683 17087251
SGTC_1037 k284-1091 78.7 µM 0.39416494612911 0.35654732883263 no 1199 0.346729631995745 1609 3334711
SGTC_1076 itraconazole 331 nM 0.393105209875262 0.356934262417028 no 1200 0.347120888152935 1625 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3157 9099274 49.47 µM 0.392777889599816 0.357053804201662 no 1201 0.347241768242565 1740 17217662
SGTC_1923 st058458 19.1 µM 0.392007485634464 0.357335221506537 no 1202 0.34752634142232 1756 3534982
SGTC_2867 9039098 71.43 µM 0.391930300355993 0.357363420439998 no 1203 0.347554856996644 1617 6463460
SGTC_2436 5633522 8.09 µM 0.391540990215221 0.357505663197995 no 1204 0.347698698116564 1764 5724242
SGTC_2830 7992007 71.43 µM 0.391372345097112 0.3575672874332 no 1205 0.34776101540677 1598 1952075
SGTC_2974 9094440 9.66 µM 0.390463502835664 0.357899449346074 no 1206 0.348096919128139 1743 25236134
SGTC_1461 k072-0203 53.8 µM 0.390223024300396 0.357987356991774 no 1207 0.348185818792599 1589 5418714
SGTC_723 4182-0001 115 µM 0.389512201239517 0.358247244494312 no 1208 0.348448643319264 1620 744821 YLR208W SEC13
SGTC_1861 st057647 17.4 µM 0.387735308168028 0.358897190180704 no 1209 0.349105961895619 1782 688668
SGTC_2816 7982706 58.44 µM 0.387662815128625 0.358923715119416 no 1210 0.349132788570783 1620 2981853
SGTC_3037 9091026 49.47 µM 0.384735207458186 0.359995483273022 no 1211 0.350216803764824 1677 25236398 YIL048W NEO1
SGTC_1765 st044815 90.4 µM 0.383207332359711 0.360555261235333 no 1212 0.350783020902646 1576 645695
SGTC_1488 4013-0813 75.9 µM 0.38272606779838 0.360731647371298 no 1213 0.35096144206824 1636 2910057
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.382361363750269 0.360865333168963 no 1214 0.35109667217371 1644 4620898
SGTC_3326 9140064 16.379 µM 0.381931266429045 0.361023011349991 no 1215 0.351256173951575 1589 1868434
SGTC_2679 rapamycin 1 nM 0.380250390897023 0.361639464232058 no 1216 0.351879778445128 1680 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_139 0099-0334 718.624 µM 0.380225278002373 0.361648676991216 no 1217 0.351889098350791 1699 97690
SGTC_1197 1601-0112 267 µM 0.379683343560317 0.361847507195617 no 1218 0.352090242911225 1611 7350313
SGTC_165 k038-0023 64.381 µM 0.379087168541412 0.362066280796379 no 1219 0.352311567233574 1615 46368543
SGTC_45 0kpi-0036 14.9 µM 0.377952541063078 0.362482770476953 no 1220 0.35273292507139 1679 2795021
SGTC_1472 k841-0093 193 µM 0.377344793176765 0.362705924537672 no 1221 0.352958694066504 1739 X1472
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.376726673928349 0.362932934617778 no 1222 0.353188368977445 1671 5379071
SGTC_2428 5615643 7.78 µM 0.376177615851911 0.363134621739883 no 1223 0.353392427651232 1712 2253075
SGTC_1504 k297-0033 30 µM 0.374870466156048 0.36361493355743 no 1224 0.353878402316743 1602 4388117
SGTC_2290 7904846 200 µM 0.374585824127581 0.363719553655684 no 1225 0.353984258691778 1638 2962154
SGTC_1816 st051957 91.6 µM 0.374392571228431 0.363790589497192 no 1226 0.354056134523821 1674 674121
SGTC_2077 5212015 200 µM 0.373544115948959 0.364102519801212 no 1227 0.354371758847706 1591 780900
SGTC_3229 9132204 49.47 µM 0.37248595826305 0.364491672313286 no 1228 0.354765532382986 1720 17682924
SGTC_3263 9137018 49.47 µM 0.370406739636521 0.365256741110868 no 1229 0.355539726437226 1573 43844957
SGTC_1459 k035-0031 35.7 µM 0.369100356017821 0.365737712403284 no 1230 0.356026461796201 1566 3877128 YMR208W ERG12
SGTC_2037 5169046 200 µM 0.368703160332624 0.365883989840261 no 1231 0.356174496432671 1705 5718022
SGTC_169 k015-0017 16.025 µM 0.368186679925696 0.366074226077057 no 1232 0.356367020848495 1742 1840002
SGTC_1450 4112-4260 37.6 µM 0.368050424515776 0.366124418789236 no 1233 0.356417817831871 1789 1633175
SGTC_2067 5224629 34.075 µM 0.367920307159016 0.366172352551394 no 1234 0.356466328883421 1627 2835000
SGTC_3306 9127676 59.7925 µM 0.36534612882471 0.367121079200998 no 1235 0.357426524410962 1645 41905287
SGTC_15 0266-0086 27.098 µM 0.365205430550894 0.367172957727044 no 1236 0.357479032433279 1760 1712902 YIL048W NEO1
SGTC_1011 4112-3381 17.4 µM 0.364402722421334 0.367468980103587 no 1237 0.357778651415824 1726 2877139
SGTC_1969 st069479 40.1 µM 0.36333927624809 0.36786127863463 no 1238 0.358175728486429 1763 3895485
SGTC_913 3487-1245 167 µM 0.362784420777813 0.368066016052094 no 1239 0.358382965300492 1585 4016153
SGTC_483 fpl-64176 144 µM 0.362305371565689 0.368242811693735 no 1240 0.35856192227106 1701 3423
SGTC_2572 astragaloside iv 100 µM 0.361701387959323 0.368465754800125 no 1241 0.358787594873211 1706 45006101 An anti-inflammatory agent.
SGTC_305 1682-2595 20.8 µM 0.360477479741237 0.368917660909052 no 1242 0.359245047393223 1720 226033
SGTC_382 3229-0966 23.2 µM 0.360394318564978 0.368948373262554 no 1243 0.359276137356885 1770 5722370
SGTC_1824 st053723 68.6 µM 0.359081175329323 0.369433442572456 no 1244 0.359767181849336 1628 675225
SGTC_1810 st050138 53 µM 0.358094092865676 0.369798203408273 no 1245 0.360136449776888 1790 3444541
SGTC_1867 st057372 64 µM 0.35799717835625 0.369834022967168 no 1246 0.360172712575046 1701 688837
SGTC_237 nikkomycin 200 µM 0.357525626124339 0.370008324570203 no 1247 0.360349172663377 1774 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1602 st001878 87.6 µM 0.356841143190986 0.370261380045523 no 1248 0.360605366716165 1760 595405 YLR310C CDC25
SGTC_1030 k029-0042 36.7 µM 0.356214788428389 0.370492994570946 no 1249 0.360839858905905 1703 6080581
SGTC_2457 5731572 11.68 µM 0.356077722823414 0.370543685186982 no 1250 0.360891179959428 1808 2865357
SGTC_1806 st050005 60.3 µM 0.355673414196382 0.370693222684815 no 1251 0.361042578585377 1669 5194765
SGTC_1668 st014914 51.6 µM 0.354507229316499 0.37112465693007 no 1252 0.361479393584455 1710 2839556
SGTC_973 1325-0077 65.9 µM 0.353676592651854 0.371432052755438 no 1253 0.361790633290263 1811 2835149
SGTC_691 1548-0686 185 µM 0.351995781182789 0.372054325657279 no 1254 0.362420713198252 1652 46495133
SGTC_1724 st037281 8.293 µM 0.35140596779087 0.372272766706765 no 1255 0.362641902942303 1646 574124 YDL195W SEC31
SGTC_1116 jasmonic acid 1.58368 µM 0.347613993413593 0.373678126779834 no 1256 0.364065047862025 1770 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1579 chlormadinone acetate 49.4 µM 0.346029770325613 0.37426576162275 no 1257 0.364660170838153 1823 45114258 A steroidal progestin.
SGTC_1661 st013063 9.66 µM 0.343403194886821 0.375240678895666 no 1258 0.365647578167789 1701 721395
SGTC_3034 9090421 49.47 µM 0.341714051120912 0.375868067387473 no 1259 0.366283048362441 1825 17173761
SGTC_2981 9013952 38.96 µM 0.341376043151164 0.375993651122841 no 1260 0.366410253930922 1600 2996344
SGTC_1053 3366-3204 134 µM 0.339365154526803 0.376741049273481 no 1261 0.367167332660852 1648 3632071 YPR165W RHO1
SGTC_3220 9131269 49.47 µM 0.33786335302225 0.377299533855975 no 1262 0.367733082639439 1719 17722206
SGTC_424 splitomicin 100 mM 0.334480860777182 0.378558341648193 no 1263 0.369008365479843 1643 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2370 9071495 200 µM 0.334471121713575 0.378561967947354 no 1264 0.369012039437077 1686 21791103
SGTC_1520 flindersine 88 µM 0.332759289174597 0.379199527410196 no 1265 0.369657995534956 1873 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_750 4073-0104 132 µM 0.332628042208447 0.379248422968738 no 1266 0.369707536490625 1713 22330957
SGTC_2934 9036370 36.88 µM 0.331633119028711 0.379619140592812 no 1267 0.370083154087656 1843 6462800
SGTC_2591 skatole 100 µM 0.330516994458749 0.380035150703165 no 1268 0.370504676872488 1719 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_902 1120-0002 2.07 µM 0.329546562661136 0.380396970000245 no 1269 0.37087130280435 1690 3280475
SGTC_112 phenothiazine 287.218 µM 0.328330783937339 0.380850413006608 no 1270 0.371330785444807 1886 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_847 0342-0274 5.54 µM 0.328017988552554 0.380967101261882 no 1271 0.371449030771178 1846 18097
SGTC_821 1114-0266 29.2 µM 0.327671148997234 0.381096502345363 no 1272 0.371580159922843 1717 3123235
SGTC_3238 9133470 49.47 µM 0.327338010656923 0.381220804213345 no 1273 0.371706123107355 1835 3534688
SGTC_1758 st042942 75.2445 µM 0.325748889001541 0.381813911897297 no 1274 0.372307175907838 1823 669317
SGTC_2407 paclitaxel 400 µM 0.32547863262684 0.381914807303338 no 1275 0.372409425862126 1815 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1135 dihydrocapsaicin 536.708 nM 0.324268487064477 0.382366691888285 no 1276 0.37286738773246 1624 107982 A Capsaicinoid.
SGTC_1656 st012921 11 µM 0.322399352124195 0.383064966657297 no 1277 0.373575087487327 1827 6732821
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.322211128380275 0.383135304725098 no 1278 0.373646377234163 1809 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1795 st049545 62.3 µM 0.319549828715029 0.38413022757819 no 1279 0.374654806220447 1897 5291882
SGTC_1735 st034310 56.75 µM 0.318630071046325 0.384474255580549 no 1280 0.375003523835529 1841 871153
SGTC_2936 9038235 15.59 µM 0.316377321380207 0.385317262518211 no 1281 0.375858064253012 1729 4749415
SGTC_1901 st060216 58.6 µM 0.315903045120837 0.38549481181491 no 1282 0.376038050263475 1699 688792
SGTC_711 k292-0785 179 µM 0.311560405579102 0.387121626834538 no 1283 0.377687314569262 1724 4146315
SGTC_2299 7976368 114.88 µM 0.310762115986861 0.387420894355651 no 1284 0.377990735850471 1868 2979718
SGTC_1026 k007-1105 30.6 µM 0.310284458748968 0.387599993332275 no 1285 0.378172324234939 1749 7066794
SGTC_3041 9091929 49.47 µM 0.309963150863737 0.38772048212191 no 1286 0.37829448927076 1811 25236887
SGTC_2707 st078556 66.6 µM 0.309837502567267 0.387767602522648 no 1287 0.378342265540445 1908 17250899
SGTC_560 2332-1943 155 µM 0.309046661423656 0.388064220277068 no 1288 0.378643016143479 1765 21177716
SGTC_862 0452-0056 10.2 µM 0.308937129533632 0.388105307136259 no 1289 0.378684676050774 1822 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2625 euphol 100 µM 0.308164563229324 0.388395142512465 no 1290 0.378978557798498 1900 6708538 A triterpene alcohol.
SGTC_225 nsc-122657 1.016 µM 0.306782727219778 0.388913705956666 no 1291 0.379504378198253 1825 275685
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.306728708634514 0.388933981610012 no 1292 0.379524938047133 1666 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1903 st060211 78.3 µM 0.306371236474372 0.389068164934103 no 1293 0.3796610030188 1884 688960
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.30636559833344 0.389070281413318 no 1294 0.379663149189217 1816 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1340 1486-1359 257 µM 0.306114225254885 0.389164646693674 no 1295 0.379758838655953 1790 4309068
SGTC_2647 atorvastatin 60.16 µM 0.305539420320243 0.389380452628268 no 1296 0.379977675658192 1844 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_404 fumagillin 50 µM 0.303711834162932 0.390066831705095 no 1297 0.380673720641594 1796 12015870 A methionine aminopeptidase binder.
SGTC_1018 4259-0013 28.1 µM 0.301970893324459 0.390720988696001 no 1298 0.381337125774753 1798 6801262
SGTC_475 α-linolenic acid 10 µM 0.301660849033542 0.390837520075168 no 1299 0.381455308295369 1858 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_67 0335-0847 266 µM 0.301164940097733 0.391023929796495 no 1300 0.381644361579829 1965 4552207 YOR254C SEC63
SGTC_1070 indatraline 8.81 µM 0.300934623470777 0.391110513197578 no 1301 0.381732173827005 1743 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_378 3970-0959 8.33 µM 0.300519402916626 0.391266621543487 no 1302 0.381890499309022 1823 6615653
SGTC_2801 7907800 81.82 µM 0.297817718212042 0.392282786844661 no 1303 0.382921145338959 1750 6620925
SGTC_2984 9022109 38.96 µM 0.297502623309718 0.392401349221212 no 1304 0.383041402750926 1820 6459207
SGTC_681 1642-0006 26.6 µM 0.297360031498119 0.39245500625752 no 1305 0.383095827274482 1775 4446530
SGTC_3105 9121040 49.47 µM 0.296833021783452 0.392653336777525 no 1306 0.383296996659649 1899 41448907
SGTC_1291 0993-0025 5.79 µM 0.295783808293797 0.393048272142145 no 1307 0.383697594563838 1873 4353356
SGTC_566 0958-0068 16.5 µM 0.294355149240187 0.393586211914313 no 1308 0.384243267593216 1839 6815365
SGTC_2096 5468907 200 µM 0.293370592879887 0.393957049910899 no 1309 0.384619450274726 1911 759785
SGTC_2386 9075165 157.42 µM 0.292389673857009 0.394326613531557 no 1310 0.384994351261018 1815 16452277
SGTC_1514 1189-1591 158 µM 0.292227929917334 0.394387560099824 no 1311 0.385056179098851 1870 767698 YMR146C TIF34
SGTC_1971 st069429 63.5 µM 0.291480367582026 0.394669281867765 no 1312 0.385341978370471 1911 1246522 YGL099W LSG1
SGTC_3166 9102297 49.47 µM 0.289789524395594 0.395306685698204 no 1313 0.385988631243114 1752 25237072
SGTC_2692 st077426 47.7 µM 0.288306923217678 0.395865818353331 no 1314 0.386555904045929 1893 25238571
SGTC_2726 cimetidine 79.27 µM 0.288251880664873 0.39588658065782 no 1315 0.386576969101497 1861 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1478 0453-0656 35.7 µM 0.287225722837303 0.396273706144427 no 1316 0.386969745881024 1837 5258496
SGTC_943 3253-1379 105 µM 0.28636639718088 0.396597971706036 no 1317 0.387298754322943 1876 668464
SGTC_2068 5226020 147 µM 0.285897153657265 0.396775070424942 no 1318 0.387478446926992 1762 1810509
SGTC_1511 0906-3109 28.5 µM 0.285768907255633 0.396823476021583 no 1319 0.387527561934093 1783 2882180
SGTC_2619 obliquin 87.91 µM 0.285342166229017 0.396984557511857 no 1320 0.387691005507131 1883 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2610 ononetin 44.17 µM 0.284163961008592 0.39742938458526 no 1321 0.388142366216984 1756 259632
SGTC_1568 digitonin 820 nM 0.283789586744508 0.397570756181605 no 1322 0.388285817582362 1983 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2286 7945697 125 µM 0.283056972743263 0.397847445547412 no 1323 0.388566582023598 1729 1245733
SGTC_2350 9023895 38.85 µM 0.282956224928841 0.397885499414473 no 1324 0.388605196822971 1856 2997209
SGTC_460 trequinsin 123 µM 0.282852916017489 0.397924521652752 no 1325 0.38864479438722 1861 5537 A vasodilator.
SGTC_2908 7930301 100 µM 0.282124947288627 0.398199521722181 no 1326 0.388923852357951 1771 2223178
SGTC_1196 1588-0294 184 µM 0.27839494752482 0.399609370400026 no 1327 0.390354598783356 1771 6144269
SGTC_867 0518-0118 155 µM 0.277934643447308 0.399783445257994 no 1328 0.390531264782792 1971 6848158
SGTC_3058 9093861 49.47 µM 0.27790571168962 0.399794387151159 no 1329 0.390542369628106 1861 17217477
SGTC_1264 0783-0040 158 µM 0.277546918683153 0.399930087992002 no 1330 0.390680092177168 1742 2855798
SGTC_581 0958-0271 211 µM 0.275716047852735 0.400622738372146 no 1331 0.391383084411521 1772 4591145
SGTC_1458 k015-0034 6.33 µM 0.274464769926251 0.401096298608612 no 1332 0.391863736975652 1743 3598957
SGTC_2255 7941087 197.44 µM 0.274281844894272 0.401165540842813 no 1333 0.391934017696297 1942 935561
SGTC_2010 4012422 159 µM 0.273200748239546 0.401574829444532 no 1334 0.392349452420017 1857 952393
SGTC_613 3914-0030 117 µM 0.270771676223226 0.402494836622039 no 1335 0.393283322722754 1859 1145395
SGTC_2995 9067767 71.4286 µM 0.268951899093321 0.40318442863658 no 1336 0.393983349062902 1850 11673567
SGTC_1818 st052136 56.3 µM 0.2675954522715 0.403698640875075 no 1337 0.394505365952001 1801 674169
SGTC_2576 guaiol 23.12 µM 0.266877925638122 0.403970713748617 no 1338 0.394781576599322 1988 227829
SGTC_1445 4239-0156 97.7 µM 0.266536487369238 0.404100197170112 no 1339 0.394913031258277 1953 4008346
SGTC_2600 tangeritin 87.95 µM 0.26435819942642 0.404926514725799 no 1340 0.395751959048991 1763 68077 A bioactive flavone.
SGTC_401 neomycin 50 µM 0.263168988170412 0.405377812502123 no 1341 0.396210166188496 1863 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2485 5633444 17.78 µM 0.262897646446062 0.405480802537411 no 1342 0.396314735195013 1757 5724239
SGTC_2460 5552655 174.22 µM 0.262416105680423 0.40566359149616 no 1343 0.396500328552818 1806 5401989
SGTC_3051 9093778 49.47 µM 0.261402176514028 0.406048537979903 no 1344 0.396891189379209 1896 17217378
SGTC_203 k066-0004 30.888 µM 0.261008604177221 0.406197985426762 no 1345 0.397042936007828 1993 6795412
SGTC_2241 6772625 37.8075 µM 0.259129504283096 0.406911706047525 no 1346 0.397767660473006 1931 2285411
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.257529174891701 0.40751978787658 no 1347 0.398385148142592 1821 279621
SGTC_1315 1237-0019 3.69 µM 0.257159402304866 0.407660323201108 no 1348 0.398527861283307 1950 825140
SGTC_1047 2043-3044 82 µM 0.257036444009769 0.407707057216528 no 1349 0.398575319848982 1796 669592
SGTC_1345 1488-0192 31.4 µM 0.256972114160513 0.407731508242921 no 1350 0.398600150023028 1946 658348
SGTC_1385 3091-4834 14.1 µM 0.256078244423725 0.408071294870673 no 1351 0.398945210227718 1913 4072814
SGTC_1236 0330-0013 258 µM 0.254745175368298 0.408578162678932 no 1352 0.39945996105351 1835 4617066
SGTC_1790 st045711 43.5 µM 0.25469229912161 0.408598270773914 no 1353 0.399480382279798 1981 585119
SGTC_3180 9109287 49.47 µM 0.254655197313962 0.408612380214636 no 1354 0.399494711456678 1864 18891271
SGTC_2931 9014674 55.67 µM 0.25374700422274 0.408957793720021 no 1355 0.399845509031206 1819 2996810
SGTC_1092 toremifene 6.32 µM 0.252830115295923 0.409306586251572 no 1356 0.400199747463861 1913 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3253 9135987 49.47 µM 0.252458617610643 0.409447927663291 no 1357 0.400343298339561 1901 4182430
SGTC_1693 xanthone 101.9 µM 0.252396953343751 0.409471389822624 no 1358 0.400367127407885 1920 7020 An insecticide.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.250455935829494 0.410210077856035 no 1359 0.401117388521678 1829 2724 A muscle relaxant with antifungal properties.
SGTC_488 nitrendipine 139 µM 0.249827295263637 0.410449386428703 no 1360 0.401360455173577 1932 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_184 1494-0393 24.714 µM 0.249163830093321 0.410701988070391 no 1361 0.401617028318724 1801 3090647
SGTC_2401 5128683 200 µM 0.248123865452804 0.411098009165141 no 1362 0.402019285458395 1794 708373
SGTC_1822 st052468 42 µM 0.246761110772045 0.411617086620321 no 1363 0.402546554499351 1868 2873678
SGTC_2524 avocatin b 10.57 µM 0.246713673032745 0.411635158593276 no 1364 0.402564912030297 1972 6710748
SGTC_910 3454-3003 490 µM 0.246009066323685 0.411903608979188 no 1365 0.402837607117089 2012 820824
SGTC_1402 3909-7673 35.9 µM 0.245738671503808 0.412006638530076 no 1366 0.402942267187212 1864 5328014
SGTC_1428 4049-0204 61.7 µM 0.245631733991328 0.412047387005173 no 1367 0.402983660755992 1963 X1428
SGTC_3249 9135183 49.47 µM 0.245128968065194 0.412238978363366 no 1368 0.403178286879876 1918 4902779
SGTC_3271 9137798 49.47 µM 0.244008594465286 0.412665999538912 no 1369 0.403612081828243 1982 6498326
SGTC_1499 4480-0877 67.3 µM 0.243551039222515 0.412840422713754 no 1370 0.403789275758808 1958 2861909
SGTC_3324 9138759 60.749 µM 0.243016232858797 0.413044316353331 no 1371 0.403996411169267 1903 45595710
SGTC_2359 9039622 200 µM 0.24267852614909 0.413173078310776 no 1372 0.404127221946907 1928 6463596
SGTC_2335 9018011 154.17 µM 0.242469679829877 0.413252712617467 no 1373 0.404208123986423 1981 6458208
SGTC_1827 berberine 7.24 µM 0.241972605061163 0.413442264445843 no 1374 0.404400695266448 1743 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.241966680189629 0.41344452392636 no 1375 0.404402990755275 1925 16623 A steroid.
SGTC_2815 7968870 71.43 µM 0.240462205052507 0.414018355904597 no 1376 0.404985979887217 1839 2977326 YHR190W ERG9
SGTC_1297 1068-0111 14.1 µM 0.239443681275903 0.414406942219033 no 1377 0.405380781068126 1820 767057
SGTC_321 4534-3890 65.3 µM 0.239306027987509 0.414459466018903 no 1378 0.405434145765334 1988 699746
SGTC_2189 6047310 154.431 µM 0.238685708914603 0.414696177584553 no 1379 0.405674649572225 1877 711535
SGTC_1013 4112-3890 241 µM 0.238517361660481 0.41476042364979 no 1380 0.405739925606171 1851 705171
SGTC_1148 3909-7663 27.7 µM 0.237835705984279 0.415020585991147 no 1381 0.406004261884639 1990 4084526
SGTC_3295 9122362 53.5725 µM 0.237720989503875 0.415064372625395 no 1382 0.406048751504101 1837 4730473
SGTC_168 3970-0862 530.542 µM 0.237137283522098 0.415287186241044 no 1383 0.406275144533314 1907 3135186
SGTC_3078 9116413 49.47 µM 0.236953200835781 0.415357460370145 no 1384 0.406346548346998 1912 17177322
SGTC_2066 5222451 176 µM 0.23621881926566 0.41563783970939 no 1385 0.406631438511805 1915 2281147
SGTC_2337 9009472 200 µM 0.234855513586088 0.416158449596643 no 1386 0.407160439442655 1991 5742383
SGTC_2248 tofa 1.1 µM 0.233028128304129 0.41685650969406 no 1387 0.407869781857022 1887 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1789 tunicamycin 25 nM 0.232983306266233 0.416873634989833 no 1388 0.407887184386542 2004 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1217 1183-1422 255 µM 0.231211395798643 0.417550760398549 no 1389 0.408575288639243 1971 2849664
SGTC_2857 9024691 58.44 µM 0.231031148355126 0.41761965466129 no 1390 0.408645301821158 1884 16478292
SGTC_204 PMA1.184 62.41 µM 0.230645428367329 0.41776709322969 no 1391 0.408795136117024 1910 2252213 YGL008C PMA1
SGTC_2786 7743617 45.45 µM 0.228973868379568 0.418406167818246 no 1392 0.409444613305013 1814 583674
SGTC_1275 0867-0008 21.1 µM 0.228538590586734 0.418572619630875 no 1393 0.409613779423967 1914 3422836
SGTC_349 k015-0014 24 µM 0.227085859715523 0.419128254581027 no 1394 0.410178489580388 1840 2196908
SGTC_2753 fluvastatin 17.09 µM 0.227040460562703 0.419145621280818 no 1395 0.410196140291495 1929 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_74 000s-0487 160.283 µM 0.2269429106652 0.419182937923777 no 1396 0.410234067276726 2038 677548
SGTC_2222 6885208 172.143 µM 0.2268712080939 0.419210367419292 no 1397 0.410261945466893 1948 609514
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.223247262972112 0.420597199929211 no 1398 0.411671534734842 1920 1377
SGTC_2231 micatex 6.853 µM 0.222747132762167 0.420788670507789 no 1399 0.411866158068084 1958 20737 An antifungal of unknown mechanism.
SGTC_1207 2099-0101 141 µM 0.222452420870863 0.420901507215826 no 1400 0.411980853978915 2024 5837381
SGTC_2699 st077704 54.6 µM 0.221996513796826 0.421076073722319 no 1401 0.412158298606923 1921 645852
SGTC_1882 5615643 20 µM 0.221885826613055 0.421118458111517 no 1402 0.412201382128043 2020 2253075
SGTC_727 3032-0951 202 µM 0.221686609162319 0.421194744855842 no 1403 0.412278927549454 1924 3652836
SGTC_1169 aniline yellow 25.8 µM 0.220061656304391 0.421817101603191 no 1404 0.412911568317949 1963 6051 A DNA damaging agent.
SGTC_661 1304-0007 33.6 µM 0.217896342753533 0.4226467197284 no 1405 0.413754938373996 1898 3117130
SGTC_3278 9139605 49.47 µM 0.216391491281416 0.423223490831961 no 1406 0.414341299068133 1993 7958859
SGTC_689 0833-0039 98 µM 0.216000623208401 0.423373327548314 no 1407 0.414493630891057 2021 5374726
SGTC_2314 7727897 200 µM 0.214684944417834 0.423877765710688 no 1408 0.415006480756674 1868 900724
SGTC_3082 9117008 49.47 µM 0.214587092928021 0.423915287480552 no 1409 0.415044628937635 1902 41448529
SGTC_1256 0570-0116 285 µM 0.214077705438897 0.424110626454603 no 1410 0.415243230629401 1859 410638
SGTC_2113 5491891 107.031 µM 0.213967697665979 0.424152814482087 no 1411 0.415286123671936 1865 789979
SGTC_679 0422-0091 41.4 µM 0.211006910843149 0.425288602445206 no 1412 0.416440939346744 1862 627384 YHR062C RPP1
SGTC_3178 9107506 49.47 µM 0.209596791127873 0.425829757384294 no 1413 0.416991192162467 1984 8897194
SGTC_1630 st005209 31.3 µM 0.208754278777766 0.42615315108911 no 1414 0.417320032572537 2090 3367314
SGTC_606 k015-0008 38.6 µM 0.208614707142383 0.426206729690456 no 1415 0.417374514271256 2035 1970475
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.203868111524047 0.428029651944956 no 1416 0.419228282518166 2001 165521
SGTC_807 1315-0151 48 µM 0.201375123897305 0.428987697905041 no 1417 0.420202632515037 2084 4011080
SGTC_604 1000-0114 314 µM 0.201347799865332 0.428998200758797 no 1418 0.420213314459199 2041 1572745
SGTC_1737 st035557 69.7 µM 0.200915249922116 0.429164471668616 no 1419 0.420382421570613 1873 5716916
SGTC_795 0685-0265 78 µM 0.200661018448794 0.429262203356501 no 1420 0.420481821230413 2042 302754
SGTC_669 0108-0021 26.2 µM 0.200616295820928 0.429279396082151 no 1421 0.420499307450044 2155 17201
SGTC_1159 4092-0538 61.2 µM 0.200228050476656 0.42942865492443 no 1422 0.420651115122582 1944 717301
SGTC_1301 naphtanilide LB 4.81 µM 0.200139657379962 0.429462638587618 no 1423 0.42068567932567 2043 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1906 st060206 94.7 µM 0.199080013557275 0.429870070514198 no 1424 0.421100077586035 2054 5133468
SGTC_2735 sertaconazole 140 nM 0.197994492528196 0.430287529652125 no 1425 0.421524686380349 2070 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1931 st074438 57.1 µM 0.197918344442095 0.430316816874307 no 1426 0.421554475643764 2074 2787313
SGTC_3170 9103054 49.47 µM 0.197742832227953 0.430384321871918 no 1427 0.421623138036155 1944 16432970
SGTC_2534 helenine 20.12 µM 0.197288980774912 0.430558890326658 no 1428 0.421800700976658 1929 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_811 0416-0114 265 µM 0.193917128761667 0.431856255002573 no 1429 0.423120385731408 1942 6612453
SGTC_2473 5854593 8.94 µM 0.19357987087203 0.431986060119078 no 1430 0.423252430379761 1932 2872951
SGTC_2729 fluphenazine 10.66 µM 0.192291420907351 0.432482031202633 no 1431 0.423756969064181 2009 3372 An atypical antipsychotic.
SGTC_1642 st009582 77.7 µM 0.192011072167359 0.432589961714021 no 1432 0.423866766232689 2089 6739311
SGTC_297 0986-0032 24 µM 0.190873822741244 0.433027839020845 no 1433 0.424312224760552 1965 2847425
SGTC_2582 agaric acid 100 µM 0.190428578175182 0.433199294813357 no 1434 0.424486652618834 1942 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1263 0774-1208 64.8 µM 0.188889369677329 0.43379211340293 no 1435 0.425089762683951 2108 906585
SGTC_2320 7373003 200 µM 0.188819126209151 0.433819170893707 no 1436 0.425117290468101 1906 5415828
SGTC_1469 k284-2957 126 µM 0.187740431973055 0.434234718284479 no 1437 0.42554006682427 2022 23884841
SGTC_619 1652-1634 108 µM 0.185820683640294 0.434974446003269 no 1438 0.426292691910193 1946 5400454
SGTC_439 amiodarone 34.4 µM 0.185413415767849 0.435131406001522 no 1439 0.426452393298397 2023 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2874 9043904 71.43 µM 0.185123403596709 0.435243182184503 no 1440 0.426566122723487 1950 4463428
SGTC_2640 pentamidine 10.38 µM 0.184907743046684 0.435326305199836 no 1441 0.426650698824065 2100 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_108 0509-0257 621.132 µM 0.184668811058605 0.435418401167062 no 1442 0.426744405276873 2062 536624
SGTC_1887 st057648 70.8 µM 0.181662680123845 0.436577407380611 no 1443 0.427923727759012 2099 688672
SGTC_1519 esterone 74 µM 0.180775028791839 0.43691974372703 no 1444 0.428272082147801 1870 698 A steroid.
SGTC_2989 9073649 71.4286 µM 0.180165167338269 0.437154973542086 no 1445 0.428511451682883 2128 21367202
SGTC_2245 6637752 200 µM 0.179204430929881 0.437525584463442 no 1446 0.42888859233429 2097 681890
SGTC_1004 4084-0029 199 µM 0.178236323082251 0.437899094421739 no 1447 0.429268692357221 2095 716894 YLR208W SEC13
SGTC_2018 5133068 143 µM 0.177580235442738 0.438152253966041 no 1448 0.429526323826045 1995 785362
SGTC_1704 st028805 70.8 µM 0.176494685000359 0.438571182595503 no 1449 0.429952661948262 1982 2876101
SGTC_898 1000-0849 28.3 µM 0.176250671218919 0.438665360313355 no 1450 0.43004850696794 2104 6751807
SGTC_2174 5790901 200 µM 0.175205687389091 0.43906871360458 no 1451 0.430459007783907 1971 786020
SGTC_1105 epirubicin 18.1 µM 0.174900932068291 0.439186358042504 no 1452 0.430578738939602 1950 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2187 6125751 200 µM 0.174813416540134 0.439220142580833 no 1453 0.430613122900169 2030 874498
SGTC_104 0074-0074 590.992 µM 0.174152134967137 0.439475438345459 no 1454 0.430872950688525 2104 3943124
SGTC_26 0302-0163 425.158 µM 0.174055133118622 0.439512889204249 no 1455 0.43091106673893 2008 3100915
SGTC_822 1487-0950 154 µM 0.173885227777046 0.439578488237412 no 1456 0.430977831146752 2114 1958375
SGTC_2298 7976326 193.81 µM 0.173058979517311 0.439897519407873 no 1457 0.431302533991029 2053 2235818
SGTC_258 haloperidol 50.781 µM 0.172375249488862 0.440161550927661 no 1458 0.431571264483737 1932 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3269 9137823 49.47 µM 0.171890515647288 0.440348753529134 no 1459 0.431761801512561 1939 17682936
SGTC_191 3914-0123 66.505 µM 0.171732594123745 0.44040974517937 no 1460 0.431823880035566 1986 3144412
SGTC_94 0334-0113 514.748 µM 0.171328802377822 0.440565702006497 no 1461 0.431982617129219 1931 6795178
SGTC_154 3389-1638 511.116 µM 0.171194735771563 0.440617484705021 no 1462 0.432035323319295 1856 5238686
SGTC_352 k048-0007 5.11 µM 0.170275783365636 0.440972453741833 no 1463 0.432396627605092 2094 6811911
SGTC_1216 1165-0504 9.65 µM 0.169131986486392 0.441414340973501 no 1464 0.43284641288478 2119 6304004
SGTC_3003 9075612 71.4286 µM 0.168045732655823 0.44183406492313 no 1465 0.433273650579404 2017 6501993
SGTC_2083 5306046 65.942 µM 0.167227794983165 0.442150155763718 no 1466 0.433595407558185 1992 539837
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.167152057123641 0.442179426417358 no 1467 0.433625203237457 2089 16486 A toxic proline analog.
SGTC_2779 methotrexate 400 µM 0.165641353489144 0.442763338639522 no 1468 0.43421960071337 2117 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1243 0416-0003 5.65 µM 0.164340240491772 0.443266340288923 no 1469 0.434731652489724 1988 2141977
SGTC_1986 st071812 45 µM 0.16259540860087 0.443941024106438 no 1470 0.435418501145653 2122 11838594
SGTC_1426 4048-4480 71.7 µM 0.162108577916382 0.44412929870507 no 1471 0.435610175673185 2099 14224343
SGTC_1330 1469-0054 61.8 µM 0.161789253237989 0.444252799672866 no 1472 0.435735908108876 2143 7102664
SGTC_1060 3448-7350 82 µM 0.161475520534219 0.444374143178725 no 1473 0.43585944505992 2115 570178
SGTC_134 0269-0018 6.916 µM 0.16122931270238 0.44446937350341 no 1474 0.435956397464853 1982 4378915
SGTC_3315 9136395 68.55 µM 0.160913427621404 0.444591558871496 no 1475 0.436080793206582 2148 16876844
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.160181088732644 0.444874850150145 no 1476 0.436369213019816 2081 6312947
SGTC_1079 idarubicin 2.36 µM 0.159817450300336 0.445015527186894 no 1477 0.436512438709323 2153 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1885 st057546 99.9 µM 0.159427378080996 0.445166438087191 no 1478 0.436666085085417 2115 702008
SGTC_1957 st077035 62.4 µM 0.157367656935173 0.445963432994591 no 1479 0.437477550927866 2149 705593
SGTC_2678 equilin 100 µM 0.157367250583553 0.445963590251203 no 1480 0.437477711043786 2123 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2499 avocadenofuran 51.48 µM 0.157309228042584 0.445986044852582 no 1481 0.437500573940788 1951 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_698 k064-0052 127 µM 0.156696669992705 0.446223114084826 no 1482 0.437741955810669 2127 5088751
SGTC_1555 citronellol 128 µM 0.156565291637504 0.446273962002402 no 1483 0.437793729195041 2146 8842 A terpine precursor.
SGTC_2000 st075254 36.4 µM 0.155649244557681 0.446628528068499 no 1484 0.438154753200647 2031 17234175
SGTC_1380 2291-0730 164 µM 0.155604979803702 0.446645662309927 no 1485 0.438172199722479 1991 2999191
SGTC_148 3253-0744 288.01 µM 0.154011354316943 0.447262597620757 no 1486 0.438800391475532 2171 6893655
SGTC_815 1582-0027 36.9 µM 0.15389826311613 0.447306383135289 no 1487 0.438844976811043 2067 3128206
SGTC_1072 oxiconazole 14.9 nM 0.151405410509662 0.448271702915589 no 1488 0.439827960848166 2121 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_629 3448-6466 76.7 µM 0.150875648428273 0.448476885001716 no 1489 0.440036905152135 2082 573744
SGTC_351 caspofungin 25 nM 0.150663369758468 0.448559106498076 no 1490 0.440120635009629 2063 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3096 9117468 49.47 µM 0.150538112037074 0.448607623371577 no 1491 0.440170042130475 2143 41316311
SGTC_923 1900-2434 73.3 µM 0.14966882077086 0.448944352648965 no 1492 0.440512954233122 2107 5910570
SGTC_157 1348-1695 65.819 µM 0.149539626601928 0.448994400538318 no 1493 0.44056392168408 2131 5380510
SGTC_2403 6032726 181.2 µM 0.14946317689586 0.449024016393652 no 1494 0.440594081764802 2034 2881040
SGTC_2034 5197015 53.07 µM 0.148696265392593 0.449321125966299 no 1495 0.440896654130879 2126 780676
SGTC_1379 2144-0755 36.5 µM 0.147921130896684 0.449621450087734 no 1496 0.441202505806653 2153 5392327
SGTC_2495 cafestol 54.53 µM 0.147138736099948 0.449924616462095 no 1497 0.441511257807845 2071 16667697 An anti-infammatory.
SGTC_2296 7971656 126.45 µM 0.146992093949326 0.449981441377213 no 1498 0.441569130325337 2039 666570
SGTC_601 0986-0029 62.9 µM 0.146444208987502 0.450193759906323 no 1499 0.441785364873095 2064 24747981
SGTC_2516 gossypol 71.55 µM 0.146360303961915 0.450226276371194 no 1500 0.441818481324082 2124 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3100 9120536 49.47 µM 0.145307817755738 0.450634184074761 no 1501 0.442233921280516 2171 16421196
SGTC_3273 9137859 49.47 µM 0.144427907888073 0.450975247125347 no 1502 0.44258129026314 2189 2377234
SGTC_369 0957-0393 4.5 µM 0.144244355695069 0.451046398610036 no 1503 0.442653758189108 2001 6997992
SGTC_36 0335-0881 14.2 µM 0.144168807224437 0.451075684393339 no 1504 0.442683585908524 2081 23828853
SGTC_2891 9063876 19.48 µM 0.143703855235938 0.45125592531096 no 1505 0.442867163381411 2205 6472478
SGTC_3123 9126162 49.47 µM 0.143113947803462 0.451484620278896 no 1506 0.443100094790017 2088 25239884
SGTC_583 1488-1091 88.9 µM 0.142598425755903 0.451684490752127 no 1507 0.443303670420155 2191 4303273
SGTC_2627 acetyl isogambogic acid 100 µM 0.141387548038418 0.452154002173363 no 1508 0.443781895339674 2020 6857789 A caspase activator and apoptosis inducer.
SGTC_1444 4112-3581 28 µM 0.141146420729664 0.452247506020881 no 1509 0.443877136130976 2064 2877249
SGTC_366 0181-0206 4.31 µM 0.139509636842086 0.452882284428627 no 1510 0.444523720655137 2173 274874
SGTC_2057 5236571 38.335 µM 0.139420122071981 0.452917003582854 no 1511 0.444559086265204 2143 54684039 YBR257W POP4
SGTC_292 k038-0015 474 µM 0.138106877318361 0.453426399278164 no 1512 0.445077975275221 2130 46368540
SGTC_719 2810-4230 27.3 µM 0.137772802720598 0.453555996037089 no 1513 0.445209989816423 2131 721079
SGTC_1905 st060207 84.5 µM 0.136125200209352 0.454195218620194 no 1514 0.445861153033364 2034 1948547
SGTC_2024 5144227 134 µM 0.135183716786713 0.454560540603268 no 1515 0.446233310515973 2133 3475211
SGTC_3137 9097352 49.47 µM 0.135147321653886 0.454574663709621 no 1516 0.446247698043108 2120 44120435
SGTC_1688 st021091 57.6 µM 0.134426826672142 0.454854263091794 no 1517 0.446532534767244 2187 3656366
SGTC_1679 SEC14.276 6.7 µM 0.132766699139298 0.455498586547353 no 1518 0.447188945698154 2179 1005053 YMR079W SEC14
SGTC_1479 0549-0158 134 µM 0.132004027212525 0.455794631715094 no 1519 0.447490553185605 2078 5440202
SGTC_3017 9080681 49.47 µM 0.131830881407941 0.455861844875623 no 1520 0.447559029944315 2052 16451914
SGTC_597 k018-0003 82.8 µM 0.131593206589231 0.455954109495543 no 1521 0.447653029576064 2143 6786234
SGTC_2616 abietic acid 100 µM 0.130764735889515 0.456275737763162 no 1522 0.447980710043274 2207 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3066 9117245 49.47 µM 0.129393053157852 0.456808314282725 no 1523 0.448523322125212 2124 17176980
SGTC_1225 1216-0074 20.6 µM 0.127451826087236 0.457562157367612 no 1524 0.449291399682118 2060 4241466
SGTC_3142 9086498 49.47 µM 0.127358579118752 0.457598372134616 no 1525 0.449328299144157 2203 25236367
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.127260686410545 0.457636391568376 no 1526 0.449367037478444 2176 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3104 9120930 49.47 µM 0.125205265118864 0.458434762221836 no 1527 0.450180524542971 2091 17014836
SGTC_728 3030-5151 22.5 µM 0.12504224167643 0.458498091318361 no 1528 0.450245054366546 2128 3125388
SGTC_1826 st055655 41.6 µM 0.124584079350052 0.458676077529724 no 1529 0.45042641651299 2053 676168
SGTC_1705 st027868 56.3335 µM 0.123731493959538 0.459007310646283 no 1530 0.450763937343334 2190 292948
SGTC_1495 4469-0029 237 µM 0.12315042303251 0.459233075540782 no 1531 0.450993991660982 2165 793680
SGTC_3033 9090887 49.47 µM 0.122677979862045 0.459416644724103 no 1532 0.451181050828889 2094 19325384
SGTC_2528 xanthyletin 44.79 µM 0.122426095613687 0.459514518628451 no 1533 0.451280786322057 2082 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2822 7994718 71.43 µM 0.120146090468832 0.460400564272234 no 1534 0.452183710942982 2196 1018011
SGTC_2531 methyl deoxycholate 70.07 µM 0.11950209099925 0.460650868344082 no 1535 0.45243879176547 2100 16667744 Haematoxylin.
SGTC_2722 naftopidil 47.16 µM 0.118664248417825 0.460976536981773 no 1536 0.452770680995851 2164 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_348 k064-0012 10.7 µM 0.118128099148077 0.461184951455142 no 1537 0.45298307971068 2177 5066323
SGTC_62 0180-0423 3.232 µM 0.116465203275694 0.461831427741446 no 1538 0.453641931076406 2151 30102 YGL099W LSG1
SGTC_1173 0443-0020 122 µM 0.116037340449568 0.461997782362513 no 1539 0.453811474134509 2097 5331295
SGTC_703 3875-0075 71.8 µM 0.115597582817672 0.462168768655103 no 1540 0.453985739348164 2132 2850814
SGTC_2137 5261020 140 µM 0.114023070880866 0.46278102652953 no 1541 0.454609752397862 2150 763655
SGTC_1766 st045414 44.774 µM 0.113422716909937 0.463014500869085 no 1542 0.454847715216317 2200 253960
SGTC_1377 2944-0135 198 µM 0.111424727392703 0.463791599257257 no 1543 0.455639776263389 2137 1894137
SGTC_2568 diosmetin 100 µM 0.110522443955485 0.464142578997181 no 1544 0.455997525601247 2230 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_43 0570-0105 72.5 µM 0.109103538530377 0.464694576157074 no 1545 0.45656018415256 2165 1114046 YDL195W SEC31
SGTC_1667 st014849 34.6 µM 0.10844693227043 0.464950038930708 no 1546 0.456820587030438 2200 5348460
SGTC_400 oxethazaine 37.5 µM 0.107733613274378 0.465227583036972 no 1547 0.457103502571737 2105 4621 A local anesthetic.
SGTC_2110 5483698 200 µM 0.107093155913511 0.465476791947071 no 1548 0.457357538366103 2107 2848765 YHR062C RPP1
SGTC_580 1123-0028 41 µM 0.106958465900192 0.465529203019479 no 1549 0.457410965040642 2203 1677248 YPR107C YTH1
SGTC_29 0299-0004 12.984 µM 0.106355311239373 0.465763912096329 no 1550 0.457650224186143 2191 16871 A napthoquinone isolated from Swertia calycina.
SGTC_716 1683-5115 658 µM 0.10584875244477 0.46596104146702 no 1551 0.457851177584611 2241 723597
SGTC_276 colchicine 750 µM 0.105575985568975 0.466067193244715 no 1552 0.457959389491637 2125 2833 A microtubule depolymerizer.
SGTC_2154 5570129 200 µM 0.10423085057054 0.466590710121024 no 1553 0.458493076044122 2218 673366
SGTC_2351 9026858 72.31 µM 0.103464372020557 0.466889043978177 no 1554 0.458797212355303 2187 1409300
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.103089171787779 0.467035088689884 no 1555 0.458946099448173 2200 688751
SGTC_2304 7443016 91.4 µM 0.102506811326387 0.467261778211049 no 1556 0.459177203337037 2197 939854
SGTC_1832 st054113 55 µM 0.102201948990716 0.467380453104247 no 1557 0.45929819039364 2236 1251267
SGTC_1702 st027038 51 µM 0.101895536212971 0.467499734465444 no 1558 0.459419796554086 2132 5521182
SGTC_63 0099-0242 26.702 µM 0.100826750470551 0.467915817624297 no 1559 0.459843995620746 2251 3898502 YLR359W ADE13
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.100033405085097 0.468224693290035 no 1560 0.460158902511494 2240 16725076
SGTC_3235 9132602 49.47 µM 0.0998389715229659 0.468300395648903 no 1561 0.460236083901525 2155 4912240
SGTC_123 0083-0120 66.675 µM 0.0995552021605134 0.468410882798024 no 1562 0.46034873027946 2063 16001701
SGTC_2033 5192550 145 µM 0.0994622793522114 0.468447063329538 no 1563 0.46038561803257 2146 182073
SGTC_2225 6654152 15.4 µM 0.099133623796128 0.468575031123727 no 1564 0.460516087819358 2212 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1081 sertraline 6 µM 0.0981996828819821 0.468938695047128 no 1565 0.460886867135975 2229 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2905 7799065 20.05 µM 0.0981433898316615 0.468960615628511 no 1566 0.460909216854539 2233 1296806
SGTC_1154 4088-0362 150 µM 0.0969434172729087 0.46942790865745 no 1567 0.461385664582638 2232 6618304
SGTC_2469 5655019 90.81 µM 0.0969360261483438 0.469430787038579 no 1568 0.46138859939262 2209 2788239
SGTC_582 0987-0078 156 µM 0.096268113699197 0.46969090377491 no 1569 0.461653817509292 2239 1625765
SGTC_2838 9002687 71.43 µM 0.0957639911691707 0.469887241532832 no 1570 0.461854008380764 2104 6457060
SGTC_552 k242-0005 476 µM 0.0945211118258162 0.47037132991727 no 1571 0.462347606354918 2141 4088318
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0940613037448468 0.470550431445986 no 1572 0.462530229594276 2121 6857784
SGTC_770 0389-1121 67.2 µM 0.0924762852565126 0.471167863236039 no 1573 0.463159816047141 2219 6753108
SGTC_2105 5350118 200 µM 0.0924448964184277 0.471180091221827 no 1574 0.463172284969547 2147 2133313
SGTC_3118 9124250 49.47 µM 0.0924424061377476 0.471181061348635 no 1575 0.463173274211809 2126 1504786
SGTC_1506 4226-2149 212 µM 0.0917181586780614 0.471463210222601 no 1576 0.463460984832306 2133 991114
SGTC_555 4296-0685 37 µM 0.0912435358503088 0.471648119299818 no 1577 0.463649541300219 2250 2908540 YHR072W ERG7
SGTC_764 1951-2361 146 µM 0.0910300354071087 0.471731299279063 no 1578 0.463734362661809 2097 5438930
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.087580969029929 0.473075227207072 no 1579 0.46510486428046 2253 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3068 9116768 49.47 µM 0.0866694617372519 0.473430447653413 no 1580 0.465467125526501 2172 41904888
SGTC_826 1683-5028 118 µM 0.0864701831379446 0.473508110671551 no 1581 0.465546328840411 2172 722377
SGTC_1002 4049-0206 172 µM 0.0863608366680094 0.473550725694971 no 1582 0.465589789193987 2215 4662749
SGTC_992 3909-8734 162 µM 0.0854234052412272 0.473916078274687 no 1583 0.465962393238383 2190 4288319
SGTC_2788 5282734 71.43 µM 0.084290899652132 0.474357487889244 no 1584 0.466412573839518 2223 743706
SGTC_744 1594-0068 283 µM 0.0841741967814684 0.474402976235024 no 1585 0.466458966675149 2205 668392
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0821073157865464 0.475208658098928 no 1586 0.467280687806766 2104 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2756 carbadox 75.1 µM 0.0814412390631151 0.475468320320124 no 1587 0.467545526992757 2190 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2206 7254556 146.969 µM 0.081190167069853 0.47556620051041 no 1588 0.467645359620996 2255 4398905
SGTC_1348 1493-0373 93.8 µM 0.080610507956339 0.475792185715535 no 1589 0.467875854631551 2214 3010129
SGTC_2384 9036245 200 µM 0.0792651090208924 0.476316731216153 no 1590 0.46841087895999 2219 6462766
SGTC_1650 st011916 45.8 µM 0.0789798158514231 0.476427966911263 no 1591 0.468524338760965 2256 242528
SGTC_900 1112-0045 141 µM 0.0783213692815617 0.476684701968776 no 1592 0.468786209722632 2266 56211 YIL048W NEO1
SGTC_2480 5767542 37.17 µM 0.0770605292628724 0.477176343317754 no 1593 0.469287696338311 2236 2867358
SGTC_1147 3809-1045 12.3 µM 0.0764719845858734 0.477405847416078 no 1594 0.469521800877414 2158 325925
SGTC_2982 9019404 25.97 µM 0.0758973698535761 0.477629926736797 no 1595 0.469750374689281 2159 22333232
SGTC_1185 1319-0113 81.3 µM 0.0751580458670243 0.477918247206136 no 1596 0.470044482223705 2198 4672763
SGTC_2946 9065502 71.43 µM 0.0742681964078491 0.478265284688879 no 1597 0.470398491355976 2288 16489101
SGTC_687 k029-0044 34.9 µM 0.0735650122298951 0.478539535180708 no 1598 0.470678255934959 2274 5829338
SGTC_1518 st038567 90.8 µM 0.0733299770842987 0.478631204055153 no 1599 0.470771768821986 2270 77966
SGTC_3189 9110682 49.47 µM 0.0729340233458032 0.478785637272704 no 1600 0.47092930965754 2199 17122418
SGTC_2719 novobiocin 32.65 µM 0.0728189793295221 0.47883050830868 no 1601 0.470975083865129 2261 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.068902896710703 0.480358068537854 no 1602 0.472533456379941 2197 75037 A free radical scavenger.
SGTC_2047 4141938 200 µM 0.0687789784466751 0.480406410601412 no 1603 0.472582775612415 2196 3807862
SGTC_2146 5545642 200 µM 0.0675886710269207 0.480870778977132 no 1604 0.473056536993605 2272 825326
SGTC_1902 st060212 70.5 µM 0.0674256153975923 0.480934393048244 no 1605 0.473121438723966 2302 688944
SGTC_3047 9092122 49.47 µM 0.0671707011893408 0.481033845542861 no 1606 0.473222904746935 2228 17173831
SGTC_2349 9023730 187.07 µM 0.0667522475707371 0.481197104029806 no 1607 0.473389469742347 2262 4126287
SGTC_541 4513-1321 94 µM 0.0645532040586144 0.482055105785262 no 1608 0.474264872349995 2128 747515
SGTC_935 2996-0153 430 µM 0.0643870830746447 0.482119924707772 no 1609 0.474331007449228 2309 23738523
SGTC_1764 st044502 93.5 µM 0.063676992215631 0.482397001118567 no 1610 0.474613712555554 2219 8407
SGTC_2976 9009005 19.48 µM 0.0628450569808476 0.482721631832193 no 1611 0.47494494323667 2293 2993148
SGTC_385 1494-0393 12.4 µM 0.062783765115511 0.482745549079919 no 1612 0.474969346961391 2235 3090647
SGTC_848 0368-0089 85.6 µM 0.062346286853339 0.48291626318901 no 1613 0.475143534283802 2298 762535
SGTC_1362 1611-0397 101 µM 0.0616294064495953 0.483196013215755 no 1614 0.475428979243444 2283 27816
SGTC_1353 1498-1206 8.11 µM 0.0615663045961091 0.483220638007474 no 1615 0.475454105527245 2280 6756808
SGTC_3346 9158254 43.5805 µM 0.0614142060102899 0.483279993040304 no 1616 0.475514669477853 2238 17639500
SGTC_383 2324-0395 7.37 µM 0.0609750795941374 0.483451360040538 no 1617 0.475689527860127 2262 3146421
SGTC_3356 9151811 4.48 µM 0.0609386186135696 0.483465588903083 no 1618 0.475704046687711 2267 1859254 YPR165W RHO1
SGTC_262 fenpropimorph 62.5 µM 0.0609022898107477 0.483479766204333 no 1619 0.475718512913964 2280 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2902 5787006 60.46 µM 0.059815488855847 0.483903899435743 no 1620 0.476151294671247 2261 591003
SGTC_87 0100-0052 35.5 µM 0.0596338481706797 0.483974788033279 no 1621 0.47622362969437 2291 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2912 7964298 10.93 µM 0.0589582874565382 0.484238442377784 no 1622 0.476492666036055 2243 2975850
SGTC_1409 3909-8004 61.9 µM 0.0576702626586584 0.484741145038856 no 1623 0.477005640609782 2238 2119279
SGTC_2334 9017922 200 µM 0.0572561636173693 0.484902768771413 no 1624 0.477170569699893 2281 3163164
SGTC_2414 st077232 92.9 µM 0.0570962523229725 0.484965183153487 no 1625 0.47723426088412 2102 729801
SGTC_478 N-arachidonylglycine 10 µM 0.056552646492122 0.48517735866714 no 1626 0.477450778379464 2308 5283389
SGTC_2921 7974240 10.71 µM 0.055811326920365 0.485466710845591 no 1627 0.477746055716253 2262 2979074 YDR527W RBA50
SGTC_2945 9067681 61.76 µM 0.0547144130612969 0.485894872735299 no 1628 0.478182993300686 2318 16456930
SGTC_1762 st045503 25.4615 µM 0.0545082022257168 0.485975365500036 no 1629 0.478265136937772 2260 4645554
SGTC_642 0335-0876 158 µM 0.0530709042941547 0.486536419042235 no 1630 0.478837706890646 2277 6812350
SGTC_3151 9099821 49.47 µM 0.0529697633165745 0.486575900741644 no 1631 0.478877999628465 2254 17174189
SGTC_1300 1094-0077 113 µM 0.0522239640601871 0.486867037243074 no 1632 0.479175119213008 2282 5532636
SGTC_192 3455-0609 60.9 µM 0.0517018023400012 0.487070876880637 no 1633 0.479383150551367 2256 3769639
SGTC_2167 5876490 200 µM 0.0510850313846678 0.487311654082521 no 1634 0.47962888182155 2276 686534
SGTC_2793 7325131 81.82 µM 0.0510504968872209 0.487325135917924 no 1635 0.479642641139434 2256 4176441
SGTC_1743 st037606 46.3785 µM 0.0502703203984095 0.487629710881041 no 1636 0.479953487373223 2281 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1006 4099-6547 255 µM 0.0498092726414738 0.487809703819279 no 1637 0.480137188678778 2281 3146833
SGTC_930 2810-3379 265 µM 0.0495685840794503 0.487903669567321 no 1638 0.480233091058252 2326 1015764
SGTC_2159 5658611 73.75 µM 0.0477329460667934 0.488620331476937 no 1639 0.480964538427752 2325 793844
SGTC_1820 st053765 18.6 µM 0.0468819666891438 0.488952579796973 no 1640 0.481303650393122 2270 3690829
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0454893784121911 0.489496305193518 no 1641 0.48185862046756 2315 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1622 st003707 19.4 µM 0.0413202693125421 0.491124214506532 no 1642 0.483520287146916 2263 10140899
SGTC_2155 5570423 76 µM 0.0409627653098136 0.491263816128937 no 1643 0.483662789955342 2276 797402
SGTC_2452 5863136 48.41 µM 0.0404162042698236 0.491477244635429 no 1644 0.483880655832539 2314 2184096
SGTC_35 0133-0054 64.071 µM 0.039968453722504 0.491652090112669 no 1645 0.484059138234895 2303 99677
SGTC_3153 9100258 49.47 µM 0.0396741522937844 0.491767014965724 no 1646 0.484176454464391 2297 25236848
SGTC_1689 st020265 53.493 µM 0.0386945026557101 0.492149573502977 no 1647 0.484566978186972 2338 5758320 YPR016C TIF6
SGTC_1945 st075991 56.6 µM 0.0382154754432716 0.49233663889771 no 1648 0.484757941144748 2227 1084980
SGTC_2896 9052656 71.43 µM 0.0367371246213279 0.492913961598744 no 1649 0.485347303721972 2332 6469436
SGTC_1772 st048439 82.2 µM 0.0367236152215684 0.492919237333665 no 1650 0.485352689558423 2240 2927068 YDL195W SEC31
SGTC_3061 glucosamine 200 µM 0.0351887936729356 0.493518628696441 no 1651 0.485964599025985 2335 91431 and experimental redox chemotherapeutic
SGTC_1862 st057513 3.81 µM 0.034960012932778 0.493607975352844 no 1652 0.486055813212244 2345 5393163
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0349595131195394 0.493608170547257 no 1653 0.486056012487065 2311 688761
SGTC_1048 3161-0300 24.5 µM 0.0339373744700161 0.494007354293829 no 1654 0.486463544912906 2341 2165101
SGTC_2502 avocadyne acetate 18.59 µM 0.0336565637567982 0.494117022550634 no 1655 0.486575508216359 2346 3952079
SGTC_1967 st070177 51.4 µM 0.0334574006156549 0.494194804306452 no 1656 0.486654918090758 2326 5729214
SGTC_2156 5649887 115 µM 0.0332951313500665 0.494258177583475 no 1657 0.486719618114393 2315 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2477 5967686 25.23 µM 0.0331306754823865 0.494322404972522 no 1658 0.486785190336962 2329 776118
SGTC_982 1491-0518 27.5 µM 0.0305953915077138 0.495312564635251 no 1659 0.487796108737485 2316 3091256
SGTC_2258 7960471 200 µM 0.0298881990862453 0.495588765305209 no 1660 0.488078108705609 2238 2974708
SGTC_635 k038-0028 24.7 µM 0.0298266406578385 0.495612807631952 no 1661 0.48810265602143 2320 4035102
SGTC_1120 ficusin 1.78878 µM 0.0297909921167472 0.495626730572219 no 1662 0.488116871414647 2300 6199 A DNA cross-linker.
SGTC_814 3342-0569 96 µM 0.0279114668012867 0.496360807538155 no 1663 0.488866381411267 2355 4346283
SGTC_2644 guaiazulene 100 µM 0.0276655758467857 0.49645684492465 no 1664 0.488964439841375 2342 3515 A coloring agent.
SGTC_2360 9040895 200 µM 0.0276042053737384 0.496480814361746 no 1665 0.48898891377084 2323 4914414
SGTC_572 0960-0087 17.7 µM 0.0270010048382985 0.496716406776693 no 1666 0.48922946628983 2344 6796365
SGTC_2095 5432005 200 µM 0.026387414745075 0.496956058222252 no 1667 0.489474166117277 2359 783734
SGTC_1860 st056228 74.6 µM 0.0259627211991393 0.497121932510684 no 1668 0.489643536297103 2275 688679
SGTC_1133 3473-0247 50 µM 0.0257189396884038 0.497217147475116 no 1669 0.489740758583237 2310 711311
SGTC_417 st075190 100 µM 0.0229068753152741 0.498315479611654 no 1670 0.490862278063602 2369 222757
SGTC_3228 9131799 49.47 µM 0.0219466472379468 0.498690527482654 no 1671 0.491245257304108 2321 17015818
SGTC_1749 st037932 54.2 µM 0.0217779975288144 0.498756399164194 no 1672 0.491312522726529 2330 594497
SGTC_1210 3013-0140 750 nM 0.0217728026726732 0.498758428186382 no 1673 0.491314594682998 2371 905973
SGTC_2520 obtusaquinone 4.71 µM 0.020723025750561 0.49916845373035 no 1674 0.491733300534955 2355 5967872
SGTC_257 daunorubicin 18.5 µM 0.0206944138026533 0.499179629099355 no 1675 0.491744712603398 2355 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2227 7312221 64.1025 µM 0.0201774769103866 0.499381536479751 no 1676 0.491950897524948 2350 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1711 st032263 62.8 µM 0.0200578968410537 0.499428242589425 no 1677 0.491998593417721 2316 3958979
SGTC_3217 9129673 49.47 µM 0.0191187653826663 0.49979505290856 no 1678 0.492373180777576 2372 17248312
SGTC_83 0170-0301 39.027 µM 0.0180693283230911 0.49979505290856 no 1679 0.492791773204025 2373 3089716
SGTC_1337 1486-1011 40.3 µM 0.0168645622972192 0.499324489882736 no 1680 0.493272331967246 2379 X1337
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.016377614106339 0.499134295660503 no 1681 0.493466569355115 2370 6708561
SGTC_1486 3970-0793 4.53 µM 0.0158032854554597 0.498909972275919 no 1682 0.493695663675174 2378 2844330
SGTC_938 3126-1755 342 µM 0.0142645308390168 0.498308961765446 no 1683 0.494309468520774 2374 1777771
SGTC_307 1501-1223 22.3 µM 0.013448552425357 0.497990256407984 no 1684 0.494634965551024 2360 2830329
SGTC_1359 1582-0056 520 nM 0.0117336512265685 0.497320453652684 no 1685 0.495319057833389 2368 3661189
SGTC_517 1365-0151 113 µM 0.0106566374886885 0.496899799475788 no 1686 0.495748697204774 2352 768657
SGTC_695 3505-6186 243 µM 0.0103252862091493 0.496770382764126 no 1687 0.495880879965006 2381 1819379
SGTC_1209 2323-2347 50.3 µM 0.0088448828082361 0.496192182187875 no 1688 0.49647144829024 2394 5412760
SGTC_3200 9114385 49.47 µM 0.00794746966896599 0.495841683706238 no 1689 0.496829451703383 2377 17018030 YLR208W SEC13
SGTC_2961 9083290 32.55 µM 0.00793544114531435 0.49583698580282 no 1690 0.496834250238723 2394 17741490
SGTC_3275 9138069 49.47 µM 0.00668857740009315 0.495350009470913 no 1691 0.497331663574971 2334 17617007
SGTC_3268 9137683 49.47 µM 0.00667314843111486 0.495343983559504 no 1692 0.497337818705674 2394 1953228
SGTC_1604 st002052 72.4 µM 0.00663024269442021 0.495327226374862 no 1693 0.497354935239447 2349 6254834 YHR062C RPP1
SGTC_3276 9139060 49.47 µM 0.00595948211338831 0.495065256461904 no 1694 0.497622524688523 2394 4870619
SGTC_2069 5228469 200 µM 0.00539168779938871 0.494843502353684 no 1695 0.497849038195621 2386 2835210
SGTC_2750 bromebric acid 70.15 µM 0.00517709653054938 0.494759693374266 no 1696 0.497934646530295 2395 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2875 9039966 71.43 µM 0.00497523708728432 0.494680857041699 no 1697 0.498015175759252 2376 6463691
SGTC_2273 7815444 169.05 µM 0.00463213937804565 0.494546860493769 no 1698 0.498152050361876 2395 2824616
SGTC_213 1246-0773 967 nM 0.00329414346551219 0.494024313231303 no 1699 0.498685829270661 2382 6251622
SGTC_290 2043-6722 48.1 µM 0.00304267778645129 0.493926105751217 no 1700 0.498786149058296 2397 773758 YLR208W SEC13
SGTC_1334 1486-0610 236 µM 0.00302539331992113 0.49391935548404 no 1701 0.498793044531051 2378 3742339
SGTC_3090 9117696 49.47 µM 0.00288488483488055 0.493864481433208 no 1702 0.498849099061685 2394 7923821
SGTC_632 0781-2353 4.65 µM 0.00153050460462284 0.493335549165731 no 1703 0.499389417241243 2403 6811515 YHR007C ERG11
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.00112088066610289 0.493175579132304 no 1704 0.499552833404642 2405 1241132 A phosphatase inhibitor.
SGTC_520 3584-0023 682 µM 0.000370547799526443 0.492882555241558 no 1705 0.499852172819242 2404 1340790
SGTC_2420 aureobasidin a 50 nM 0.000303124321083272 0.492856224860049 no 1706 0.499879070893954 2402 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2897 9048598 12.99 µM 7.2980780536538e-05 0.492766348877521 no 1707 0.499970884881013 2404 6467404
SGTC_2923 7992654 58.14 µM 0 0.492737848395858 no 1708 0.5 2405 2985126
SGTC_3195 9113082 49.47 µM 0 0.492737848395858 no 1709 0.5 2406 17018038
SGTC_3132 9126706 49.47 µM -0.000249808230436426 0.492640293473951 no 1710 0.499900340935923 2408 850858
SGTC_991 3996-0057 64.7 µM -0.000275798231286046 0.492630143903584 no 1711 0.499889972426075 2405 715343
SGTC_3067 9117431 49.47 µM -0.000594167086079267 0.492505815435969 no 1712 0.499762961641687 2408 17150885
SGTC_1283 0922-0125 16.4 µM -0.000640439121681294 0.4924877454772 no 1713 0.499744501773804 2406 3360884
SGTC_2712 st079126 47.7 µM -0.00110112582344728 0.492307840910339 no 1714 0.499560714441756 2407 3152970
SGTC_248 streptozotocin 5.23457 mM -0.00251825457969647 0.491754442381634 no 1715 0.49899536283718 2410 5300 DNA alkylating agent.
SGTC_2983 9022671 12.99 µM -0.00257442608294214 0.49173250734315 no 1716 0.498972953722233 2413 6405161
SGTC_3032 9089427 49.47 µM -0.00358307386174027 0.491338633510887 no 1717 0.498570563401369 2409 17173707
SGTC_3018 9082602 49.47 µM -0.00393122374345273 0.491202684001947 no 1718 0.498431672674644 2396 17332089
SGTC_665 3914-0008 307 µM -0.00396687990325542 0.491188760638251 no 1719 0.49841744803586 2411 1069549
SGTC_2062 5245942 200 µM -0.0045511550707825 0.490960608736081 no 1720 0.498184358085506 2411 1376160
SGTC_2345 9052315 157.45 µM -0.00513182152829416 0.490733868918443 no 1721 0.497952708402999 2423 6469265
SGTC_3205 9113483 49.47 µM -0.00629749021718198 0.490278705354279 no 1722 0.497487681497711 2414 17018033
SGTC_2792 7535235 81.82 µM -0.00664773895659973 0.4901419446996 no 1723 0.497347955394539 2437 1281891
SGTC_1911 st060208 74.3 µM -0.00732321494970699 0.489878196747318 no 1724 0.497078486041328 2427 688783
SGTC_2444 5485484 36.41 µM -0.00925419618305952 0.489124246056669 no 1725 0.49630816256644 2431 6790631
SGTC_92 0063-0024 660.874 µM -0.00926426731084377 0.489120313889216 no 1726 0.496304144939982 2418 3594437
SGTC_3284 9108171 64.8615 µM -0.00966735397779258 0.488962933750463 no 1727 0.496143343831136 2428 8687505
SGTC_3256 9138902 49.47 µM -0.0110540775933978 0.488421518167097 no 1728 0.49559015088585 2424 17228773
SGTC_149 3970-0822 46.1 µM -0.0126732133493725 0.487789389471174 no 1729 0.494944254700909 2430 3114250 YBL034C STU1
SGTC_564 3555-0129 330 µM -0.012714052957448 0.487773445621668 no 1730 0.494927963367084 2426 563260
SGTC_1237 0330-0133 46.1 µM -0.0137219084933893 0.487379983434204 no 1731 0.494525922321113 2428 X1237 YHR072W ERG7
SGTC_1596 piperlongumine 63 µM -0.0145714096507584 0.487048351595792 no 1732 0.494187054312555 2424 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_850 0388-0143 75.9 µM -0.014890687079208 0.486923713032261 no 1733 0.4940596948672 2441 67273
SGTC_2044 5102272 200 µM -0.0149313985920652 0.486907820285715 no 1734 0.494043455128889 2445 592666
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0167773558936765 0.486187227407215 no 1735 0.49330711736721 2447 4213774
SGTC_2620 irigenin 100 µM -0.0184497985712636 0.485534407041374 no 1736 0.492640012837956 2453 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_644 1498-1197 63.3 µM -0.018749586084059 0.485417392193311 no 1737 0.492520435609987 2455 6741615
SGTC_1419 3993-2473 62.6 µM -0.0188474981961066 0.485379174825936 no 1738 0.492481381229972 2447 704026
SGTC_3146 9095609 49.47 µM -0.0190281933612064 0.485308645666543 no 1739 0.492409307214392 2455 17173999
SGTC_1627 st003713 25.6 µM -0.019426950669383 0.485153003852222 no 1740 0.492250255468989 2455 16195070 YER133W GLC7
SGTC_202 3594-0513 34.79 µM -0.0208112142687998 0.484612719741493 no 1741 0.491698125992133 2434 708429
SGTC_1277 0873-0036 22 µM -0.0214718514085536 0.484354880085961 no 1742 0.491434628803386 2464 5965735
SGTC_419 nsc-638432 893 µM -0.022143581623484 0.484092717629105 no 1743 0.491166710939958 2461 368090
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0224973686175517 0.483954644615162 no 1744 0.4910256055045 2479 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1246 0422-0085 105 µM -0.02250016253982 0.483953554234302 no 1745 0.491024491172849 2444 264295
SGTC_1045 1348-1485 165 µM -0.0235463020514855 0.483545287064819 no 1746 0.490607252506812 2445 6810614
SGTC_333 3486-0131 40.1 µM -0.0242940294233806 0.483253488981943 no 1747 0.490309037778506 2456 6744690
SGTC_3116 9124943 49.47 µM -0.0246546737011423 0.483112751966671 no 1748 0.490165204612746 2458 41905195 YPL160W CDC60
SGTC_1268 0828-0275 2.46 µM -0.0251218318045333 0.482930452365219 no 1749 0.489978893207284 2491 745337
SGTC_789 1309-1135 70.6 µM -0.025632262931272 0.482731270367104 no 1750 0.489775326210375 2452 3092424
SGTC_1990 st072050 59.8 µM -0.0264911456711414 0.482396124266058 no 1751 0.489432797926548 2453 17233948
SGTC_60 0986-0278 202 µM -0.0265843125939523 0.48235977018561 no 1752 0.489395642787494 2447 3110598
SGTC_1490 4089-0339 670 nM -0.0268681890859805 0.482249001426206 no 1753 0.489282432892501 2454 742542
SGTC_2997 9067075 71.4286 µM -0.0285040410407668 0.481610718079759 no 1754 0.488630072527838 2479 27209819
SGTC_818 4072-2707 53.5 µM -0.028579338356152 0.481581339390289 no 1755 0.488600045478066 2456 882871
SGTC_1837 st055472 66.5 µM -0.0305496358166534 0.480812626135166 no 1756 0.487814354088454 2561 676091
SGTC_674 0498-0004 451 µM -0.030585120628234 0.480798782350746 no 1757 0.487800204308874 2473 4231473
SGTC_1056 3448-1962 115 µM -0.0319498472338062 0.480266375640739 no 1758 0.48725602328276 2499 715507
SGTC_1673 st016611 27.3 µM -0.0319841648631867 0.480252988107805 no 1759 0.48724233952287 2535 5226799
SGTC_3071 9117417 49.47 µM -0.0320292198623925 0.4802354118901 no 1760 0.487224374383101 2481 45595590 YGL055W OLE1
SGTC_618 k072-0232 33.2 µM -0.0329760036537627 0.479866074957264 no 1761 0.486846861770984 2480 5872756 YGL099W LSG1
SGTC_361 000s-0510 1.45 µM -0.0339331125898481 0.479492727792855 no 1762 0.48646524417838 2496 660
SGTC_1309 pyrazolanthrone 13.4 µM -0.0348425458993926 0.479137994506882 no 1763 0.486102647245448 2469 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2818 7996756 12.99 µM -0.0352792924262967 0.478967643142526 no 1764 0.485928517650302 2460 2241621
SGTC_46 0329-0187a 2.197 µM -0.035404703324994 0.478918727794865 no 1765 0.485878517176891 2459 46494817
SGTC_2760 etidronate 98.04 µM -0.0359861826270721 0.478691931394352 no 1766 0.48564668824255 2494 3305 A chelator and antioxidant.
SGTC_1391 3442-0225 151 µM -0.0360118914867604 0.478681904236854 no 1767 0.485636438535047 2476 5227075
SGTC_860 0443-0016 25.1 µM -0.0374683276756396 0.478113876567775 no 1768 0.485055796629729 2476 5337942
SGTC_3083 9117465 49.47 µM -0.038332913755063 0.477776698529711 no 1769 0.484711124340719 2544 16420915
SGTC_633 0437-0093 97.7 µM -0.0385935114686858 0.477675071705006 no 1770 0.484607237769171 2467 2831118
SGTC_2086 5274770 176.623 µM -0.0391920941328697 0.477441644406964 no 1771 0.484368618381759 2495 689278
SGTC_1740 st038286 13.222 µM -0.0401292092654161 0.477076216296863 no 1772 0.483995057462559 2514 716786
SGTC_2808 7946468 45.46 µM -0.0406047788470707 0.476890775259739 no 1773 0.483805487165737 2518 2970879
SGTC_177 1327-0068 8.361 µM -0.0415843617412766 0.476508817805026 no 1774 0.483415019990313 2477 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2969 9091408 28.7 µM -0.0433515996807902 0.475819793933806 no 1775 0.482710629629133 2525 4286311
SGTC_251 melphalan 456.522 µM -0.043898788570492 0.475606466422503 no 1776 0.482492540476165 2513 460612 A DNA alkylator.
SGTC_359 0081-0058 15.9 µM -0.0469246191175555 0.474426941534255 no 1777 0.481286653242531 2561 3494159
SGTC_709 3807-1509 243 µM -0.0479849437678381 0.474013659814165 no 1778 0.480864120958418 2481 1886677 YPL242C IQG1
SGTC_1422 4031-0024 15.5 µM -0.0484546985931309 0.473830572840112 no 1779 0.480676933644852 2487 782427
SGTC_1855 st056195 39.6 µM -0.0497536653098914 0.473324329369468 no 1780 0.480159345323189 2523 4028379
SGTC_375 3970-0961 9.27 µM -0.0519071499220052 0.472485151804561 no 1781 0.479301338572115 2527 2898222
SGTC_484 loperamide 105 µM -0.0523297964685451 0.472320467609184 no 1782 0.479132955843628 2491 3955 An opioid-receptor agonist.
SGTC_2828 7998861 71.43 µM -0.0535603409353145 0.471841013095148 no 1783 0.478642727240129 2504 2988188
SGTC_3121 9125696 49.47 µM -0.0538086749469352 0.471744260149897 no 1784 0.478543798963201 2479 1235365
SGTC_2845 9003024 42.97 µM -0.0544103216655395 0.471509860633052 no 1785 0.478304127769026 2589 2990173
SGTC_2233 sulbentine 40.3845 µM -0.0551028216319554 0.471240077220942 no 1786 0.478028274112431 2488 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2885 9057732 51.95 µM -0.0552120752565474 0.471197515510351 no 1787 0.477984754473552 2565 6471414
SGTC_2215 7188065 200 µM -0.056653263878108 0.470636105588852 no 1788 0.477410702101601 2523 940217
SGTC_3329 9141233 27.5565 µM -0.0570185477407565 0.470493819780186 no 1789 0.47726521010799 2578 4909101 YNL103W MET4
SGTC_2355 9061122 103.12 µM -0.0572102748343496 0.470419139518858 no 1790 0.477188846716631 2542 5302957
SGTC_2606 farnesol 9.78 µM -0.0574926209950033 0.470309163816636 no 1791 0.477076391990371 2533 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_866 0495-0101 262 µM -0.0579715136646658 0.470122637127964 no 1792 0.476885659578251 2533 635694
SGTC_2020 4017018 200 µM -0.0581096309088239 0.470068842256169 no 1793 0.476830651501097 2562 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1786 berberine 21.6 µM -0.0584716515583823 0.469927842512509 no 1794 0.476686471314221 2502 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_768 0384-0033 77.3 µM -0.0585576405856305 0.469894352073697 no 1795 0.476652225334324 2526 3965305 YMR134W ERG29
SGTC_842 0271-0008 11.1 µM -0.0593078769140535 0.469602164040689 no 1796 0.476353443645243 2619 1221709
SGTC_3312 9133330 71.43 µM -0.0595781602994576 0.469496903118358 no 1797 0.476245806509955 2635 17617324
SGTC_220 paclitaxel 373.376 µM -0.0606277814067434 0.469088152117484 no 1798 0.47582782392648 2538 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_486 niguldipine 82 µM -0.0614161823164677 0.468781148766896 no 1799 0.475513882531272 2505 1236 A calcium channel blocker.
SGTC_264 promethazine 12.5 mM -0.0620890677390139 0.468519141827325 no 1800 0.475245951441164 2505 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2894 9048625 32.47 µM -0.0640254220675308 0.467765244058719 no 1801 0.47447499222477 2539 4092861
SGTC_1941 st076221 61.8 µM -0.0656363788511192 0.467138124140545 no 1802 0.473833662706897 2587 2828568
SGTC_2004 4023728 41.89 µM -0.0656764560121285 0.467122523770943 no 1803 0.473817708657059 2535 360084 YDR527W RBA50
SGTC_2435 5706476 10.6 µM -0.0662189344718803 0.466911364478491 no 1804 0.473601761165298 2543 5725375
SGTC_3318 9139014 38.6185 µM -0.068788294719968 0.465911370628142 no 1805 0.472579067738811 2518 16643984
SGTC_1253 0550-0034 176 µM -0.0689846394540088 0.465834962116868 no 1806 0.472500923154647 2588 5969915
SGTC_2593 nobiletin 86.24 µM -0.0691496833277816 0.465770735462231 no 1807 0.472435237032701 2584 72344 An anti-infammatory.
SGTC_2723 salbutamol 83.58 µM -0.0695664915276762 0.465608538950203 no 1808 0.472269354093984 2552 9884233 β2-adrenoceptor agonist
SGTC_2327 6189656 200 µM -0.0713959989506185 0.464896673373777 no 1809 0.471541296930143 2591 5349088
SGTC_1546 5-methoxyflavanone 78.7 µM -0.0715308303665392 0.464844214574204 no 1810 0.471487644155601 2558 147795
SGTC_608 k048-0125 159 µM -0.0720662565155096 0.464635902598278 no 1811 0.471274589888273 2548 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2237 6667747 47.222 µM -0.0727476884973056 0.464370799869122 no 1812 0.471003449560299 2600 729940 YDL015C TSC13
SGTC_2888 9058547 12.99 µM -0.0729758576509085 0.464282036995748 no 1813 0.470912664539638 2556 16476514
SGTC_1805 st050013 60.3 µM -0.0729773142675511 0.464281470345197 no 1814 0.470912084978979 2604 4037144
SGTC_1698 5-fluorocytosine 1.055 µM -0.0734445173672192 0.464099723527317 no 1815 0.470726196744221 2540 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_456 gingerol 170 µM -0.0736061909075544 0.464036832597648 no 1816 0.470661872436509 2641 442793 A herb.
SGTC_766 1391-0721 126 µM -0.0743533788562252 0.463746188541493 no 1817 0.470364602174683 2558 1020919 YIL115C NUP159
SGTC_2106 5357045 167.29 µM -0.0746726286887151 0.463622011398084 no 1818 0.470237592998289 2633 668842
SGTC_3201 9113999 49.47 µM -0.0756318381386873 0.463248933466411 no 1819 0.469856002913806 2696 16649224
SGTC_2022 5136654 200 µM -0.0756681709606235 0.463234802697944 no 1820 0.46984154963171 2633 1713771
SGTC_3046 9092212 49.47 µM -0.0763972671668701 0.462951248269699 no 1821 0.46955152186924 2530 25236637
SGTC_2415 st077333 57.7 µM -0.0771603363794789 0.462654501485954 no 1822 0.469247997260979 2536 2766255
SGTC_3057 9095946 49.47 µM -0.0777757198815188 0.462415202709226 no 1823 0.469003230329562 2526 24540043
SGTC_411 enrofloxacin 100 µM -0.0782483981527154 0.462231405694362 no 1824 0.468815231923165 2595 71188 A bacterial gyrase inhibitor.
SGTC_694 1315-0438 43.2 µM -0.0786416227627172 0.462078509718201 no 1825 0.468658839930987 2588 6793154
SGTC_1927 st060202 13.8 µM -0.0786430568894167 0.462077952102607 no 1826 0.468658269563693 2528 688887
SGTC_2306 7482397 179.52 µM -0.0797761033060448 0.46163742560081 no 1827 0.468207665267229 2596 891448
SGTC_3172 9105863 49.47 µM -0.0803886242238174 0.461399298082775 no 1828 0.467964087088857 2539 2348785
SGTC_2046 4110841 106 µM -0.0809944146482629 0.461163800764924 no 1829 0.467723197188779 2565 44119630 YMR134W ERG29
SGTC_3304 9125678 46.087 µM -0.0813207250750968 0.461036955222794 no 1830 0.467593446173792 2568 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2956 9076196 2.52 µM -0.0819317654096041 0.46079943826386 no 1831 0.467350487102003 2562 16423868
SGTC_600 1495-0418 41.6 µM -0.0823560304622547 0.4606345307836 no 1832 0.467181799915309 2558 5377768
SGTC_2212 7123476 200 µM -0.0823875822996424 0.460622267177698 no 1833 0.467169255184342 2566 1085715
SGTC_3130 9127414 49.47 µM -0.0826529842952873 0.46051911189621 no 1834 0.467063734994601 2539 1494646
SGTC_1267 0828-0272 9.49 µM -0.082775965401234 0.460471313040744 no 1835 0.467014840179639 2615 745334
SGTC_1621 st003705 32.4 µM -0.0835145727768248 0.460184251819847 no 1836 0.466721195235472 2546 24207032
SGTC_2437 5741531 144.16 µM -0.0841468424237963 0.459938535447343 no 1837 0.466469840905654 2624 2262990
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0841922225730639 0.459920900132483 no 1838 0.466451800861174 2725 94937 An inhibitor of serotonin biosynthesis.
SGTC_2680 butyl paraben 22.24 µM -0.0843032719241488 0.459877745246299 no 1839 0.466407655522963 2552 7184 An antifungal and steroid mimetic.
SGTC_886 0866-0150 153 µM -0.0848235641286323 0.459675560806182 no 1840 0.466200829792841 2591 271463
SGTC_1176 0848-0131 83.3 µM -0.0854733070858712 0.459423086728049 no 1841 0.465942557828373 2625 6769040
SGTC_1892 st058411 7.36 µM -0.0863204159670094 0.45909394571198 no 1842 0.465605854726985 2579 3934738
SGTC_1912 st060209 90.8 µM -0.0865113467906589 0.459019764112079 no 1843 0.465529968227543 2620 688787
SGTC_1103 duloxetine 36.1 µM -0.0866457351175772 0.458967551600926 no 1844 0.465476555603934 2708 60835 A selective serotonin reuptake inhibitor.
SGTC_1368 1852-0141 284 µM -0.0869215088791706 0.458860410282023 no 1845 0.465366951305796 2630 2838987
SGTC_819 1013-0258 27.7 µM -0.0873233526965413 0.458704294629745 no 1846 0.465207246076327 2570 5753198
SGTC_291 SEC14.278 35.5 µM -0.0875367322596036 0.458621399613048 no 1847 0.46512244467864 2570 1068044
SGTC_1308 1187-1617 41.4 µM -0.0875558671287718 0.458613966068203 no 1848 0.465114840168042 2543 2882570
SGTC_1198 1612-1005 86.7 µM -0.0902428787971763 0.457570256342384 no 1849 0.464047105478927 2709 6998509
SGTC_1963 st076565 50.3 µM -0.0920732054990614 0.456859473842614 no 1850 0.463319938459097 2577 4914280
SGTC_3209 9113616 49.47 µM -0.093022613980115 0.456490838172167 no 1851 0.462942797878449 2590 16649353
SGTC_950 1165-0508 94.1 µM -0.094126998908835 0.45606207548457 no 1852 0.462504136780889 2630 6148369
SGTC_1489 4065-0444 182 µM -0.0950608764770794 0.455699549902275 no 1853 0.462133236674756 2579 2877968
SGTC_579 4491-1009 110 µM -0.095208995257959 0.455642054474933 no 1854 0.462074412631911 2560 1271041
SGTC_3262 9137218 49.47 µM -0.0966427088262461 0.455085576522334 no 1855 0.461505069238514 2539 17650664
SGTC_1390 3413-2614 145 µM -0.0987332006715789 0.454274336527429 no 1856 0.460675053661452 2612 3421432
SGTC_3281 9140613 49.47 µM -0.100085634757903 0.453749609928122 no 1857 0.460138169933259 2609 16013766
SGTC_493 zm226600 134 µM -0.100209805850415 0.45370143721313 no 1858 0.460088880630441 2739 5240098 A potassium channel opener. YCR052W RSC6
SGTC_167 3672-0051 66.205 µM -0.101677180520827 0.453132214612265 no 1859 0.459506457781689 2591 3237971
SGTC_2181 6316240 54.2555 µM -0.101896192084886 0.453047264082244 no 1860 0.459419536253881 2646 12779990
SGTC_1563 conessine 56.1 µM -0.10237161038494 0.452862865527535 no 1861 0.45923085844626 2652 441082 An anti-amoebic, histamine inhibitor.
SGTC_2111 5486399 200 µM -0.10296127936916 0.452634167153189 no 1862 0.458996851081366 2565 689674
SGTC_1456 k015-0012 13 µM -0.104259192548838 0.452130837421799 no 1863 0.458481830499775 2586 2989616
SGTC_537 1334-0398 209 µM -0.105299756307715 0.451727363116852 no 1864 0.458068978169936 2582 5846986
SGTC_1214 0358-0031 63.7 µM -0.107543035365676 0.450857711052993 no 1865 0.457179092990665 2887 4301366
SGTC_1525 8-methoxypsoralen 92.5 µM -0.108643331484652 0.450431245173042 no 1866 0.456742695296396 2633 4114 Related to psoralen; DNA damaging agent.
SGTC_3109 9122853 49.47 µM -0.109153131013297 0.450233670367429 no 1867 0.456540517071258 2664 1234709
SGTC_2123 5259487 200 µM -0.109223280724458 0.450206484536118 no 1868 0.456512697712862 2669 2173474
SGTC_558 k064-0027 21.3 µM -0.111909137717993 0.449165783958595 no 1869 0.455447725633941 2690 5088526
SGTC_968 1309-0633 340 µM -0.112257873289578 0.44903068337702 no 1870 0.455309471427515 2605 3761976
SGTC_1034 k072-0165 12.7 µM -0.112483689228716 0.448943205160594 no 1871 0.455219950886516 2628 5835461
SGTC_573 3702-0553 84.7 µM -0.112923538660515 0.448772820226528 no 1872 0.455045587269022 2623 1222756
SGTC_977 1348-1378 135 µM -0.113587723262279 0.448515552257268 no 1873 0.45478230988849 2606 X977
SGTC_1046 2001-0062 216 µM -0.114205062703373 0.448276448893622 no 1874 0.454537619356539 2606 739778
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.115889286573079 0.447624223518351 no 1875 0.453870143280032 2607 688803
SGTC_944 3370-0224 231 µM -0.116180297156818 0.447511542294129 no 1876 0.453754825795038 2633 4580514
SGTC_270 tamoxifen 5.46 µM -0.116850457135971 0.447252068039474 no 1877 0.453489279288684 2660 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2922 7999257 32.47 µM -0.118843241577049 0.446480630460435 no 1878 0.452699774799314 2612 2988377
SGTC_140 0062-0056 502.533 µM -0.120780745771269 0.445730786840841 no 1879 0.45193235054611 2599 3758964
SGTC_70 0141-0289 43.283 µM -0.122146394728538 0.445202376348911 no 1880 0.451391539628726 2741 352408
SGTC_794 k038-0031 316 µM -0.124138270602991 0.444431834688213 no 1881 0.450602898470873 2617 6624242
SGTC_1797 st048695 56.8 µM -0.124144664513464 0.444429361590296 no 1882 0.450600367249446 2698 592262 YIL048W NEO1
SGTC_2280 7785178 200 µM -0.12415171911611 0.444426632946045 no 1883 0.450597574475518 2648 2954328
SGTC_2533 agelasine 13.65 µM -0.1248295437884 0.444164469973237 no 1884 0.450329248880915 2707 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3243 9134147 49.47 µM -0.125173951630044 0.444031272336798 no 1885 0.45019291930796 2636 24282180
SGTC_9 0092-0002 10.449 µM -0.126147867278013 0.443654650650493 no 1886 0.449807438737065 2651 759368
SGTC_1884 5633444 25 µM -0.126417740097502 0.443550297464078 no 1887 0.449700630120827 2758 5724239
SGTC_81 0411-0046 9.971 µM -0.126579833756432 0.443487621711267 no 1888 0.449636479433596 2601 12925265
SGTC_3075 9116269 49.47 µM -0.126894049425505 0.443366129909181 no 1889 0.449512128219855 2774 17015205 YNL244C SUI1
SGTC_2583 asiatic acid 100 µM -0.127056246307216 0.443303418405517 no 1890 0.449447940556146 2754 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1298 1079-1278 263 µM -0.127583360226133 0.443099625865034 no 1891 0.449239350060414 2658 2840950
SGTC_1109 tnp00067 928.257 nM -0.128246230620678 0.44284336858975 no 1892 0.44897705767954 2647 676295
SGTC_128 0906-2981 13.371 µM -0.130130763730948 0.442114962983228 no 1893 0.448231485559718 2729 6740226
SGTC_790 1575-0012 79.1 µM -0.131818047452895 0.441462963722983 no 1894 0.447564105657371 2643 378741 YLR208W SEC13
SGTC_2725 haloperidol 53.21 µM -0.133652610665684 0.440754232817859 no 1895 0.446838640027921 2651 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3 0833-0587 95.581 µM -0.133866847264985 0.440671480977617 no 1896 0.446753933163622 2633 5382644
SGTC_1515 3460-0031 42.1 µM -0.13390839499807 0.44065543289271 no 1897 0.446737505914624 2669 2876596
SGTC_408 cantharidin 100 µM -0.137016521620341 0.439455176745901 no 1898 0.445508867955775 2697 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1404 3909-7820 48.3 µM -0.137680216472437 0.439198951361524 no 1899 0.445246577724059 2672 23741373
SGTC_2696 st077691 74.316 µM -0.138103884141791 0.439035403949369 no 1900 0.445079158046398 2788 757133
SGTC_2408 sulbentine 18.36 µM -0.138307028802623 0.438956988193898 no 1901 0.444998885358989 2776 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1233 0325-0408 14.2 µM -0.139128120743174 0.438640063401508 no 1902 0.444674453591062 2730 12874
SGTC_1074 carmofur 3.8 µM -0.139315912725914 0.438567585035147 no 1903 0.444600257983152 2642 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2893 9048488 25.97 µM -0.140492939056242 0.43811335842328 no 1904 0.444135265489055 2671 6467338
SGTC_2333 9017922 200 µM -0.141042669909055 0.437901239504506 no 1905 0.443918116768496 2791 3163164
SGTC_2877 9040724 71.43 µM -0.141291140038536 0.437805370774629 no 1906 0.443819974312895 2805 6463895
SGTC_2829 7992743 58.44 µM -0.141787299324852 0.437613945570838 no 1907 0.443624008190704 2807 16462845
SGTC_2364 9055074 200 µM -0.142151842267104 0.437473309098629 no 1908 0.443480034851538 2737 6470630
SGTC_2564 betulinic acid 100 µM -0.142447855890461 0.437359116259637 no 1909 0.443363132110279 2841 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1213 1315-0166 115 µM -0.143533605943978 0.436940312435295 no 1910 0.44293438615494 2796 768401
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.144583907221095 0.436535249416502 no 1911 0.442519701944574 2627 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1739 st037196 92.5 µM -0.144773658930109 0.436462076165066 no 1912 0.442444790107749 2738 612214
SGTC_1204 4049-0315 18.3 µM -0.145345068273983 0.436241738830037 no 1913 0.442219216576604 2928 588402
SGTC_3333 9141820 12.094 µM -0.145401459018844 0.436219995443546 no 1914 0.442196956387955 2714 1939433
SGTC_1158 4092-0494 91.8 µM -0.145589055562164 0.436147662547192 no 1915 0.442122904158994 2796 1148199
SGTC_1234 0326-0494 15.5 µM -0.145634581347159 0.43613010917739 no 1916 0.442104933525834 2784 1547813
SGTC_984 1492-0255 2.91 µM -0.14710285765422 0.435564053755008 no 1917 0.441525417168276 2809 1585198
SGTC_2149 5554786 194.827 µM -0.149276386066952 0.434726349527665 no 1918 0.440667773837259 2676 745063 YPR165W RHO1
SGTC_329 k048-0121 21.3 µM -0.150137453994786 0.434394564304016 no 1919 0.440328085429016 2746 6832902
SGTC_3246 9135460 32.98 µM -0.150415318303367 0.434287507952498 no 1920 0.440218478251195 2686 41446951
SGTC_1146 3579-1023 7 µM -0.1523082138786 0.433558336388897 no 1921 0.439471923383015 2802 X1146
SGTC_3119 9125183 49.47 µM -0.1532992602952 0.433176660563294 no 1922 0.439081141989732 2742 22695334
SGTC_435 c-PAF 6.7 µM -0.153390524066084 0.433141515817137 no 1923 0.439045158578492 2705 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3111 9122088 49.47 µM -0.155364971477467 0.432381306204139 no 1924 0.438266798758979 2753 16876704
SGTC_8 0354-0001 70 µM -0.155925233953295 0.432165637171291 no 1925 0.438045977379782 2694 4993152
SGTC_2693 st077581 40.7 µM -0.156841598793983 0.431812932673994 no 1926 0.437684843723336 2717 25238761
SGTC_1857 st056007 79.3 µM -0.157162361749782 0.431689485355051 no 1927 0.437558445295125 2759 619834
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.157293096692798 0.431639173234042 no 1928 0.437506930290127 2800 551469
SGTC_2745 rifampicin 24.3 µM -0.15916349980005 0.43091948789044 no 1929 0.436770030082532 2777 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2691 st077356 60.2 µM -0.160501460259711 0.430404814004999 no 1930 0.436243035709195 2847 2839272
SGTC_1121 fusaric acid 630.51 nM -0.160654988026045 0.430345763949869 no 1931 0.43618257158373 2712 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.16107330863516 0.430184876824796 no 1932 0.436017831172695 2862 1273210
SGTC_3024 9090631 49.47 µM -0.161394704402657 0.4300612751017 no 1933 0.435891268636355 2698 25236383
SGTC_3102 9121669 49.47 µM -0.16189432785876 0.429869144553124 no 1934 0.435694534804313 2729 41905072
SGTC_3164 9100705 49.47 µM -0.162378559372935 0.429682948833181 no 1935 0.435503876952188 2850 17174235
SGTC_845 0330-0138 4.51 µM -0.162471774950629 0.429647107562125 no 1936 0.435467176636776 2768 9039800
SGTC_390 dec-rvkr-cmk 16.7 µM -0.163488898347054 0.429256062654352 no 1937 0.435066756694451 2756 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1342 1486-1464 234 µM -0.165162397824523 0.4286128175691 no 1938 0.434408080468672 2709 3253938
SGTC_2898 9056270 58.44 µM -0.165615054644185 0.428438861806152 no 1939 0.43422994950887 2678 19154699
SGTC_505 gw-5074 63.9 µM -0.165658668032604 0.428422101939134 no 1940 0.434212787333448 2812 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2427 5545055 42.75 µM -0.166167994251285 0.428226386291831 no 1941 0.434012373067917 2715 5372858
SGTC_1106 tegaserod maleate 11.7 µM -0.167001867229233 0.427905997193374 no 1942 0.433684289861212 2751 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2840 9008771 71.43 µM -0.167117844648233 0.427861440328742 no 1943 0.433638662732073 2866 2992978
SGTC_245 methotrexate 289.6 µM -0.167589365465984 0.42768029825682 no 1944 0.433453168999185 2765 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1322 1348-1070 12 µM -0.168839554156462 0.427200092666765 no 1945 0.432961422606017 2699 6758089
SGTC_1238 0333-0287 48.8 µM -0.170309527135111 0.426635604511473 no 1946 0.432383359573997 2717 7226
SGTC_2395 5646831 180.19 µM -0.170763612796885 0.426461260211636 no 1947 0.432204820771207 2852 6808628
SGTC_2090 5301565 104.445 µM -0.171103833609465 0.426330643260854 no 1948 0.432071060771276 2740 2056344
SGTC_1082 camptothecin 424.86 nM -0.1721771971614 0.425918612517852 no 1949 0.431649112093332 2628 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2303 7774051 200 µM -0.17275925664647 0.425695211848153 no 1950 0.431420331952429 2854 2953184
SGTC_1921 5740136 50 µM -0.173882272562816 0.425264253759585 no 1951 0.430978992417448 2786 1774243
SGTC_1616 st002734 56.1 µM -0.174023116519579 0.425210211090054 no 1952 0.430923647530179 2743 4026101
SGTC_3327 9140648 26.9345 µM -0.174192995182566 0.425145029499721 no 1953 0.430856895207515 2821 8029710
SGTC_102 gallobenzophenone 83.616 µM -0.174320538085693 0.425096093272688 no 1954 0.430806779646504 2866 70837
SGTC_664 1222-0054 14.9 µM -0.174656967343011 0.424967016141618 no 1955 0.430674591508473 2738 6813991
SGTC_2819 7996655 46.38 µM -0.175103732958818 0.424795618919385 no 1956 0.430499062556471 2802 6456960
SGTC_1788 fluconazole 20 µM -0.175874741985037 0.424499862366415 no 1957 0.430196174499833 2802 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2523 spermine 47.74 µM -0.177603682935125 0.423836801010148 no 1958 0.429517115983518 2818 1103 A DNA binding polyamine.
SGTC_874 0599-0792 117 µM -0.177771867833607 0.423772312360373 no 1959 0.429451070810122 2814 765305
SGTC_1224 0823-0416 294 µM -0.178842718821573 0.423361754275385 no 1960 0.429030600612882 2848 3598164
SGTC_1815 st051655 58.2 µM -0.179507731772868 0.423106833997573 no 1961 0.42876952342976 2760 5984156
SGTC_2264 7948757 110.76 µM -0.180030043033312 0.422906638308045 no 1962 0.428564491294564 2705 2971411
SGTC_2813 7971799 71.43 µM -0.180261543723321 0.422817913212871 no 1963 0.42847362237122 2848 2234054
SGTC_2558 carylophyllene oxide 100 µM -0.180852644950306 0.422591385168082 no 1964 0.428241619834871 2721 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_162 k030-0015 37.8 µM -0.181400018787743 0.422381637620065 no 1965 0.428026802066037 2829 1809920 YMR134W ERG29
SGTC_330 1488-0319 80.1 µM -0.181547415310963 0.422325160675421 no 1966 0.427968959698876 2790 6846614
SGTC_1846 st056244 14.8 µM -0.182447010373161 0.421980503482075 no 1967 0.427615967953437 2797 5393182
SGTC_2226 7298446 200 µM -0.18355845123816 0.421554765436052 no 1968 0.427179930149261 2782 3283010
SGTC_2038 4100038 30.985 µM -0.183980526469892 0.421393113274413 no 1969 0.427014365885602 2833 3596803
SGTC_2467 5474540 200 µM -0.184958135776005 0.421018745976234 no 1970 0.426630935887837 2720 5413519
SGTC_636 0kpi-0074 126 µM -0.186274516549242 0.420514761844344 no 1971 0.426114745276951 2817 616434
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.186449322802533 0.420447846020981 no 1972 0.426046208237601 2736 442882
SGTC_1839 st053978 48 µM -0.186607103998256 0.420387449362611 no 1973 0.425984348203739 2735 3788398
SGTC_2861 9024595 19.48 µM -0.188509685672214 0.419659312985155 no 1974 0.425238561779849 2797 16482810
SGTC_3019 9081971 49.47 µM -0.189137423267554 0.419419131954128 no 1975 0.424992555633461 2883 16451803
SGTC_2553 4-methylesculetin 85.09 µM -0.18948969756958 0.419284360109354 no 1976 0.424854514489002 2775 5319502
SGTC_2556 citropten 84.59 µM -0.189847156116936 0.419147614573851 no 1977 0.424714451280565 2745 2775 A potential DNA crosslinker.
SGTC_482 fipronil 114 µM -0.189997338651473 0.419090165255204 no 1978 0.424655607997712 2716 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1211 1056-0033 32.3 µM -0.190350084378153 0.418955236233533 no 1979 0.424517404679968 2764 6741922
SGTC_3293 9120939 62.045 µM -0.190385750546505 0.418941594072187 no 1980 0.424503431440009 2895 934087
SGTC_3292 9120825 59.784 µM -0.190500864885007 0.41889756398057 no 1981 0.424458332758024 2795 24824900
SGTC_2943 9068529 45.32 µM -0.190505482097186 0.418895797963938 no 1982 0.424456523879893 2726 3270634
SGTC_2796 7949634 45.45 µM -0.190644296140138 0.418842704370948 no 1983 0.424402141658447 2717 2971588
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.192883571133276 0.417986431410018 no 1984 0.42352507588209 2782 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1960 st011366 51.8 µM -0.193967296726184 0.417572166525271 no 1985 0.423100744493288 2728 3972846
SGTC_1760 st045453 10.4495 µM -0.195447355416373 0.41700654721362 no 1986 0.422521373553097 2829 3323419 YIL048W NEO1
SGTC_324 1315-0088 19.6 µM -0.196044335980779 0.416778453626853 no 1987 0.422287732075852 2828 6787421
SGTC_721 1187-1332 279 µM -0.196113441940884 0.416752051515793 no 1988 0.422260687702307 2712 25730
SGTC_380 3970-0968 6 µM -0.19729195748852 0.416301854498412 no 1989 0.421799536327863 2770 2891601
SGTC_2133 5320837 200 µM -0.197399818822935 0.416260656570201 no 1990 0.42175733569456 2911 2841355
SGTC_543 3844-1095 191 µM -0.197509219242699 0.416218871723971 no 1991 0.421714533813581 2858 4230703
SGTC_630 4356-0227 183 µM -0.197772230308566 0.416118420071389 no 1992 0.421611637003435 2768 779312
SGTC_78 0336-0123 156.75 µM -0.198052772866375 0.416011278666407 no 1993 0.421501887314329 2702 6765896
SGTC_106 0092-0003 11.579 µM -0.199362378388975 0.415511212738839 no 1994 0.420989643715472 2843 1072148
SGTC_563 tetrahydrosecaminediol 614 µM -0.199514397806807 0.415453173776517 no 1995 0.420930190964716 2903 334274 A psychoactive constituent of the cannabis plant.
SGTC_2272 7805186 180 µM -0.200492825386942 0.41507966752424 no 1996 0.420547584298938 2803 2956062 YPR165W RHO1
SGTC_1042 0350-0096 82 µM -0.202236664146678 0.414414162661281 no 1997 0.419865855712917 2720 3122515
SGTC_1378 2093-0007 380 nM -0.202802751485997 0.414198178273203 no 1998 0.419644603626492 2871 3618014
SGTC_2777 climbazole 1.536 µM -0.204491567329674 0.413553983602142 no 1999 0.418984690534053 2814 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3163 9099914 49.47 µM -0.20500101206393 0.413359702743374 no 2000 0.418785667152892 2857 16268368
SGTC_2586 curcumin 80 µM -0.20537080340301 0.413218693117329 no 2001 0.418641214797733 2900 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_455 paf C-16 10 µM -0.205578053596317 0.413139668923088 no 2002 0.418560261022031 2756 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_667 1498-1044 59 µM -0.208836774590877 0.411897588082001 no 2003 0.417287831130914 2812 6739982
SGTC_676 falcarinol 140 µM -0.208981288513613 0.411842526080169 no 2004 0.417231422858134 2931 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_65 0798-0905 34.986 µM -0.213305237687105 0.410195843303555 no 2005 0.415544444240117 3181 3602145
SGTC_96 0929-0093 37.281 µM -0.213325601381366 0.410188091950512 no 2006 0.415536503048395 2775 6991579
SGTC_1374 2889-5571 141 µM -0.213965326576033 0.409944601175207 no 2007 0.415287048192832 2849 2853281
SGTC_752 1896-0090 130 µM -0.214122041456757 0.409884957998354 no 2008 0.415225943893789 2775 772567
SGTC_2694 st077685 81.9 µM -0.214127149021955 0.409883014175815 no 2009 0.415223952450576 2750 2838096
SGTC_2651 TUB2.036 5 µM -0.214524325384242 0.409731864718904 no 2010 0.415069099785146 2890 15992207 YFL037W TUB2
SGTC_3280 9140961 49.47 µM -0.215026376296684 0.409540823395072 no 2011 0.414873377104067 2762 4901226
SGTC_1313 1220-0047 237 µM -0.215329915700707 0.409425330445488 no 2012 0.414755053641786 2830 3528706
SGTC_2763 lisinopril 49.32 µM -0.215466557154331 0.409373342645189 no 2013 0.414701791614999 2796 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_64 000l-0018 272.079 µM -0.215885492672292 0.409213960718322 no 2014 0.41453850281716 2755 6811119
SGTC_3308 9128332 17.569 µM -0.216178265426272 0.409102585692004 no 2015 0.414424397335146 2937 17332805 YDL196W YDL196W
SGTC_989 1501-0895 10.3 µM -0.217146270107329 0.408734394876344 no 2016 0.414047177896489 2824 2830112
SGTC_972 1319-0219 195 µM -0.2184412848173 0.408241948322559 no 2017 0.413542650739124 2862 23903702
SGTC_451 chloral hydrate 100 µM -0.218868331358067 0.408079589927648 no 2018 0.4133763081421 2902 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1664 st014217 9.02 µM -0.218927519568755 0.408057088465924 no 2019 0.413353254455543 2817 3982782
SGTC_180 1486-1293 102.781 µM -0.220709201533705 0.40737989232162 no 2020 0.412659433175106 2872 4140536
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.220975951756946 0.407278527498918 no 2021 0.412555578925591 2933 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1299 1079-1439 3.74 µM -0.221458619802438 0.407095129902164 no 2022 0.412367676642905 2819 323161
SGTC_357 1325-0123 420 µM -0.221990845434436 0.40689292570516 no 2023 0.412160504916237 2921 1098503
SGTC_77 0828-0286 12.516 µM -0.222558273027583 0.406677374844608 no 2024 0.411939657593319 2760 745345
SGTC_946 3434-1334 87.4 µM -0.22283907795582 0.4065707148701 no 2025 0.411830376397733 2954 4047976
SGTC_136 0097-0015 404.482 µM -0.224343500311928 0.405999398502774 no 2026 0.411245015174733 2786 4861337
SGTC_3186 9110464 49.47 µM -0.224468869195787 0.40595179768778 no 2027 0.411196243833985 2924 17018021
SGTC_611 3453-1652 23.7 µM -0.224669435659747 0.40587564829309 no 2028 0.411118221782663 2897 1560575
SGTC_2449 5812982 45.77 µM -0.225382591764374 0.405604912021149 no 2029 0.410840826519951 2835 776185
SGTC_1363 1636-0063 10.4 µM -0.226349424650911 0.405237944260581 no 2030 0.410464830195812 2809 6072185
SGTC_519 k048-0011 62.8 µM -0.229380631449819 0.4040879712051 no 2031 0.409286544370339 2935 6836379
SGTC_533 1222-0222 6.71 µM -0.232872228136882 0.402764363476321 no 2032 0.407930312178559 3010 3982874
SGTC_314 1671-0008 2.74 µM -0.233453988397377 0.402543935416262 no 2033 0.407704447201237 2809 3913060
SGTC_1987 st072290 61.9 µM -0.233454166958166 0.402543867764608 no 2034 0.407704377880773 2876 54697379
SGTC_3227 9130768 49.47 µM -0.233780827363272 0.40242011022624 no 2035 0.407577567360011 2821 17720899
SGTC_2711 st079103 59.1 µM -0.234308467668116 0.402220230732828 no 2036 0.407372756315898 2873 54693780
SGTC_2667 digitoxin 100 µM -0.234769456395154 0.402045620960676 no 2037 0.407193837746013 2900 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1922 5578187 25 µM -0.23612806978282 0.401531129631907 no 2038 0.406666646580933 3056 1350412
SGTC_1854 st056233 32.9 µM -0.236410306381138 0.401424271242699 no 2039 0.406557149748712 2824 5393174
SGTC_1438 4092-1045 4 µM -0.236659701999059 0.401329853003756 no 2040 0.406460400020489 2821 1351342
SGTC_936 3005-4620 401 µM -0.236789659073659 0.401280655071251 no 2041 0.406409987156545 3041 777207
SGTC_576 1073-0113 22.7 µM -0.237222368928282 0.401116855111533 no 2042 0.406242141817278 2873 5439563
SGTC_1907 st060210 83.7 µM -0.238668982199538 0.400569373859738 no 2043 0.405681135177675 3001 688793
SGTC_2539 epi(13)torulosol 80 µM -0.239123952257363 0.400397227467383 no 2044 0.405504734619567 2934 6708597
SGTC_932 2857-0803 154 µM -0.240653831039028 0.399818511436502 no 2045 0.404911712429508 3064 674898
SGTC_2097 5376186 200 µM -0.240683187065316 0.399807408910953 no 2046 0.404900335374014 2957 742755
SGTC_2352 9027995 87.8 µM -0.240764730280626 0.399776569479705 no 2047 0.404868733368529 2891 2997347
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.241637793436196 0.399446418489867 no 2048 0.404530417389191 2849 4174840
SGTC_2920 7982904 15.77 µM -0.243639141132821 0.398689875567968 no 2049 0.403755155667503 2938 6456808
SGTC_745 0469-0705 296 µM -0.244558223157919 0.398342574506325 no 2050 0.403399257471566 3026 3486736
SGTC_453 enantio-paf c16 10 µM -0.245463175947007 0.398000691232615 no 2051 0.403048908720897 2945 13871343 A lipid and platelet activating factor
SGTC_1662 st014054 52 µM -0.245511880550191 0.397982293276395 no 2052 0.40303005513837 2846 2838777
SGTC_1600 coumarin 106 71.1 µM -0.245648076541237 0.397930847025606 no 2053 0.402977334781354 2993 100336 A hepatotoxic, DNA x-linker.
SGTC_1367 1812-0510 76.9 µM -0.246262989920077 0.397698593661921 no 2054 0.402739328801141 2884 1142582 YDR527W RBA50
SGTC_1324 1418-0026 34.4 µM -0.247249453361084 0.397326081254271 no 2055 0.40235758741575 2949 1372513
SGTC_589 1227-0070 34.1 µM -0.247784112213971 0.397124220269436 no 2056 0.40215072414193 2975 2841384
SGTC_2153 5569715 200 µM -0.24875617206498 0.396757288727315 no 2057 0.40177469758321 2855 2054701
SGTC_536 3852-0578 10.6 µM -0.248891847406546 0.39670608148545 no 2058 0.401722220864944 3009 2869208
SGTC_3184 9108758 49.47 µM -0.249969943343084 0.396299244699802 no 2059 0.401305296311666 2793 902885
SGTC_958 1222-0007 33 µM -0.250545144212501 0.396082229588331 no 2060 0.40108289880469 3020 7312461
SGTC_2132 5317594 122.667 µM -0.251290187280609 0.395801183305456 no 2061 0.400794880615837 2837 794577
SGTC_86 0417-1630 471.922 µM -0.251753474213027 0.395626448804801 no 2062 0.400615810680575 2881 3634867
SGTC_356 1634-0012 32.5 µM -0.25435968100869 0.39464387696625 no 2063 0.399608848340002 2957 735457
SGTC_2199 6590217 200 µM -0.254743658512204 0.394499169216699 no 2064 0.399460546871544 2914 703109
SGTC_2252 omeprazole 400 µM -0.254813419194569 0.394472880406932 no 2065 0.399433605152587 2912 4594 A proton pump inhibitor.
SGTC_2878 9043973 25.97 µM -0.256130940803899 0.393976472277598 no 2066 0.398924865669814 3016 6465167
SGTC_122 0236-0016 402.397 µM -0.258958795841305 0.392911591932117 no 2067 0.397833516214334 2902 6808838
SGTC_3097 9117246 49.47 µM -0.261033136796835 0.392130969805468 no 2068 0.397033476700453 2859 16423892
SGTC_2192 5915882 198.485 µM -0.261860356181396 0.391819789011025 no 2069 0.396714552270815 2848 2876149
SGTC_1925 st057770 10.1 µM -0.262165684319594 0.391704949102046 no 2070 0.396596854142377 2875 5989122
SGTC_2529 gangaleoidin 93.61 µM -0.262729608910859 0.391492870803589 no 2071 0.396379496827874 2858 4565183
SGTC_3080 9117754 49.47 µM -0.262914107343162 0.391423492436833 no 2072 0.396308391322349 3081 9550191
SGTC_2040 5100729 123 µM -0.263678087226316 0.391136243981672 no 2073 0.39601399099917 2868 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_615 k087-0205 167 µM -0.263698404925378 0.391128605548882 no 2074 0.396006162364662 2883 9642773
SGTC_2657 nystatin 74.44 µM -0.264947432526976 0.390659114751351 no 2075 0.395524978855878 2928 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2575 plumbagin 510 nM -0.265263323252944 0.390540401372559 no 2076 0.395403308257221 2831 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2688 kanamycin b 96.69 µM -0.265413044493966 0.390484138914313 no 2077 0.395345644176492 3012 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2483 5729050 27.16 µM -0.266523736795228 0.390066833080741 no 2078 0.394917940495645 3037 2865180
SGTC_200 k038-0079 37.545 µM -0.266874325706052 0.389935137189943 no 2079 0.394782962520473 2889 3436683
SGTC_124 0136-0217 7.121 µM -0.267438773274101 0.389723133572364 no 2080 0.394565674742515 3014 3976905
SGTC_1940 st075990 51.1 µM -0.269600573277898 0.388911476509237 no 2081 0.393733779629005 3140 1084979
SGTC_2220 6782180 200 µM -0.27010704253536 0.388721390396598 no 2082 0.393538952130523 2938 833803
SGTC_2780 5215298 71.43 µM -0.270406740161349 0.38860892156833 no 2083 0.393423677644121 3027 2834131
SGTC_3161 9100388 49.47 µM -0.270461043158017 0.388588544046098 no 2084 0.393402791757816 2890 25236368
SGTC_508 roscovitine 141 µM -0.270621655111735 0.388528275250567 no 2085 0.393341019374951 2864 160355 A CDKinase inhibitor.
SGTC_856 0433-0016 11.3 µM -0.270735625042663 0.388485510257722 no 2086 0.393297187440314 2954 3911780
SGTC_2858 9025781 8.96 µM -0.271069819303042 0.388360118176933 no 2087 0.393168666768462 2984 4894980 YPL153C RAD53
SGTC_760 0568-0725 82.9 µM -0.271278960419614 0.388281652849642 no 2088 0.393088243550648 3031 3916171
SGTC_2872 9044037 25.97 µM -0.271939807622254 0.388033746924773 no 2089 0.392834151076192 2856 6465195
SGTC_2271 7849410 118.62 µM -0.272129951089867 0.387962426187262 no 2090 0.392761050309313 2926 972430
SGTC_1683 st010134 710 nM -0.273606958369063 0.387408545755744 no 2091 0.392193342993554 2873 3818134
SGTC_217 ketoconazole 989 nM -0.274169462108499 0.387197666002964 no 2092 0.391977197478712 2969 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3197 9113331 49.47 µM -0.275007466624923 0.386883564177797 no 2093 0.391655250935351 3115 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2993 9054257 71.4286 µM -0.27550754321907 0.386696160164432 no 2094 0.391463165665904 2882 6470217 YGL055W OLE1
SGTC_1778 st046819 58.9 µM -0.275982532283063 0.386518182180751 no 2095 0.391280741314218 2907 671715
SGTC_2353 9059630 146.67 µM -0.277093564807859 0.38610197254556 no 2096 0.390854131488838 3006 4779114
SGTC_671 0560-0003 407 µM -0.277534694542931 0.385936754975014 no 2097 0.390684784650097 2938 3238678
SGTC_1061 3448-9325 110 µM -0.280253354878426 0.384918985083265 no 2098 0.389641567366895 2910 723482
SGTC_188 3229-0966 278.469 µM -0.280630861322597 0.384777722573555 no 2099 0.389496771459961 2988 5722370
SGTC_2608 thymoquinone 42.66 µM -0.280706842625342 0.384749292299319 no 2100 0.389467630018746 2947 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2201 6605497 169.863 µM -0.281984446001914 0.384271338488732 no 2101 0.388977718422904 2936 670741
SGTC_1251 0490-5699 265 µM -0.283055625911373 0.383870743621527 no 2102 0.38856709823243 3080 3883818
SGTC_2445 5742597 35.57 µM -0.283091447072765 0.383857349532014 no 2103 0.388553368894852 2899 1774255
SGTC_883 0850-0245 24.6 µM -0.284335587389967 0.383392232311214 no 2104 0.388076608146308 3110 6823229 YPR165W RHO1
SGTC_2055 5235184 200 µM -0.284881166597846 0.383188322508793 no 2105 0.387867592630328 3072 2836034
SGTC_3283 9109332 35.8195 µM -0.284988906292418 0.383148058706548 no 2106 0.387826320578437 2903 17027281
SGTC_1613 st002381 52.1 µM -0.285358107657282 0.383010092667441 no 2107 0.387684899516326 2917 551167
SGTC_2754 granisetron 64.02 µM -0.28701425741257 0.38239139256131 no 2108 0.38705070173791 3049 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1179 1021-1431 9.29 µM -0.287124394305382 0.382350258533602 no 2109 0.387008537132296 2982 2840958
SGTC_740 k014-0057 261 µM -0.287701947610672 0.382134575140135 no 2110 0.386787449526278 3012 4012779
SGTC_3305 9127027 53.8275 µM -0.288897618523684 0.381688176179811 no 2111 0.386329863103087 2944 41905295
SGTC_2394 5221648 200 µM -0.289599311917552 0.381426274957623 no 2112 0.386061396732089 3045 788586
SGTC_3339 9145883 14.936 µM -0.289601388974429 0.381425499793947 no 2113 0.386060602135546 3055 2030670
SGTC_1273 0849-0096 14.1 µM -0.290526820915669 0.381080173257556 no 2114 0.38570661752695 2950 5286025
SGTC_298 1391-0729 10 µM -0.290555679291586 0.381069406225372 no 2115 0.385695580511827 2913 3237558
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.29265856449624 0.380285070101542 no 2116 0.384891572262743 2884 5355888
SGTC_836 0330-0104 1.35 µM -0.29400324378411 0.379783788006542 no 2117 0.384377712340138 2929 46494820
SGTC_2621 lithochol-11-enic acid 100 µM -0.295432124518929 0.379251337825178 no 2118 0.383831898019238 3012 6708711
SGTC_909 3448-9333 149 µM -0.295782853342656 0.379120679145015 no 2119 0.383697959228338 2896 3344074
SGTC_249 wiskostatin 11.211 µM -0.295912683399721 0.379072316436232 no 2120 0.383648382335398 2953 2775510 A n-wasp and actin depolymerizer.
SGTC_542 3381-0244 89.3 µM -0.296322457010559 0.378919684989036 no 2121 0.383491918720353 3104 1112843
SGTC_2732 terfenadine 20 µM -0.296667849510737 0.378791048718005 no 2122 0.383360052460459 2922 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2281 7943571 200 µM -0.297026138758581 0.378657623433346 no 2123 0.383223276671531 3141 1244024
SGTC_2598 perillyl alcohol 100 µM -0.297380924749083 0.378525516996156 no 2124 0.383087852582279 3085 10819 An apoptosis inducer.
SGTC_1384 3089-0840 101 µM -0.297587458063235 0.37844861976184 no 2125 0.383009024069391 3064 1069836
SGTC_1126 isoteolin 1.0172 µM -0.297597435351092 0.378444905103608 no 2126 0.383005216115036 2918 133323
SGTC_1484 3473-2379 286 µM -0.299225018089022 0.37783908806684 no 2127 0.382384180801223 2967 671917
SGTC_2851 9015922 71.43 µM -0.299935422048633 0.377574756358511 no 2128 0.382113207293406 3112 2996893
SGTC_1431 4049-0260 9.09 µM -0.301913955760285 0.376838873246973 no 2129 0.381358828376617 2914 3854841
SGTC_1427 4048-4900 550 nM -0.302951603607032 0.376453115774596 no 2130 0.380963372041142 3061 24132586
SGTC_3022 9087993 49.47 µM -0.304033778291718 0.376050936351608 no 2131 0.380551078568405 3014 17173644
SGTC_2465 5809242 33.21 µM -0.304333992342419 0.375939388622822 no 2132 0.380436725212475 2908 2731748
SGTC_1485 3909-9022 254 µM -0.304401389438876 0.375914347938036 no 2133 0.380411054684596 2980 714516
SGTC_412 gemfibrozil 100 µM -0.306112840852179 0.375278651468702 no 2134 0.379759365672942 2998 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1392 3455-1037 33.9 µM -0.306190901205133 0.37524966502155 no 2135 0.379729649861801 3098 981132
SGTC_2944 9067346 25.62 µM -0.306605535988304 0.375095708925466 no 2136 0.379571819685989 3119 6473075
SGTC_2094 5332512 191.667 µM -0.30673741322252 0.375046746377889 no 2137 0.379521624997431 3102 755774
SGTC_2713 st079149 53.4 µM -0.307022517980594 0.374940901364839 no 2138 0.379413116282468 3023 3103253
SGTC_1507 4075-3230 155 µM -0.309056178148976 0.374186179574731 no 2139 0.378639396571115 2919 659771
SGTC_2275 7947463 200 µM -0.310721296660428 0.373568587810182 no 2140 0.378006252861674 3096 1225414
SGTC_2128 5255449 168.493 µM -0.311420796252712 0.373309240418815 no 2141 0.377740373132214 2960 736008
SGTC_1666 st014829 29 µM -0.311713431785061 0.373200759500507 no 2142 0.377629159568734 2911 3858230
SGTC_1741 st038134 10.228 µM -0.311835620289448 0.373155466809032 no 2143 0.377582725902623 3190 1272587
SGTC_1410 3909-8106 77.9 µM -0.313912769674575 0.372385780153874 no 2144 0.376793645738021 3042 1039210
SGTC_955 1216-0110 33 µM -0.315517109947715 0.37179164118975 no 2145 0.37618453107562 2906 3619719
SGTC_655 k060-0012 42 µM -0.316319387467523 0.371494646326208 no 2146 0.375880048502189 2964 5994525
SGTC_2506 ethyl hematommate 54.16 µM -0.31690037879005 0.371279617069568 no 2147 0.375659597299714 3024 3940691 An allergen.
SGTC_774 k060-0086 136 µM -0.31721329535552 0.371163820936722 no 2148 0.37554088112769 3141 5911235
SGTC_1715 st032160 10.2275 µM -0.31802178222301 0.370864690881412 no 2149 0.375234207086739 3078 5289825
SGTC_223 busulfan 5 mM -0.318746018628364 0.370596798691744 no 2150 0.374959557746128 3049 2478 A DNA alkylator.
SGTC_1714 st033236 13.627 µM -0.322048315536604 0.36937608899949 no 2151 0.373708046089622 3165 2916566
SGTC_577 r071-0003 38.6 µM -0.322989954138802 0.369028248378463 no 2152 0.373351425055454 2977 4568517 YMR134W ERG29
SGTC_554 4483-2211 187 µM -0.323059675345533 0.369002497675335 no 2153 0.373325024277442 3061 747107
SGTC_2438 5259590 200 µM -0.323360035063632 0.368891570089491 no 2154 0.373211296238509 3063 1201127
SGTC_195 4234-0266 16.654 µM -0.324588676253933 0.368437927291257 no 2155 0.372746199309515 3009 2303354
SGTC_3277 9138724 49.47 µM -0.324694778228386 0.368398760573929 no 2156 0.372706043545358 3013 15943418
SGTC_2293 7624732 200 µM -0.327119554153798 0.367504046882515 no 2157 0.371788731315793 2936 894453
SGTC_363 0455-0021 3.06 µM -0.327328792915003 0.367426873867834 no 2158 0.371709608629939 2954 4597466
SGTC_1293 1000-1278 195 µM -0.328343317032252 0.367052765414566 no 2159 0.371326047840459 3106 678847
SGTC_286 k060-0067 22.9 µM -0.328407756637646 0.36702900739848 no 2160 0.371301689491722 3015 5985051
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.328565403409328 0.366970887300276 no 2161 0.3712421007501 3223 6710655
SGTC_398 bronopol 33.3 µM -0.329353763146216 0.366680286172279 no 2162 0.370944155798113 2953 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1834 st055981 52.8 µM -0.33007186433281 0.366415649876893 no 2163 0.370672830987752 3131 471719 YDL150W RPC53
SGTC_3335 9143315 29.6265 µM -0.331086960871652 0.366041672532773 no 2164 0.370289400229006 2993 4899691
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.332364340500856 0.36557124683729 no 2165 0.369807080830763 3038 368090
SGTC_57 miconazole 162.5 nM -0.332947107906002 0.365356695855626 no 2166 0.369587104559307 3008 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1111 tnp00062 510.699 nM -0.333543708663382 0.365137095643107 no 2167 0.369361950844894 3144 676306
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.334693090429904 0.364714149351574 no 2168 0.368928307093407 2995 641818 YHR062C RPP1
SGTC_2655 perillic acid 100 µM -0.337038531515739 0.363851591616094 no 2169 0.368043926857348 3015 5702197 An apoptosis inducer.
SGTC_584 0986-0246 15.4 µM -0.33744701592279 0.363701438055886 no 2170 0.367889973626767 3076 53315 YDR232W HEM1
SGTC_495 decylubiquinone 155 µM -0.338902432876 0.363166615987626 no 2171 0.367341615811822 3063 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_525 k781-2675 26.7 µM -0.33896167009219 0.363144853729054 no 2172 0.367319302710813 3023 3651118 YDL195W SEC31
SGTC_278 4092-0821 23.9 µM -0.339525209136351 0.362937845806953 no 2173 0.367107054792132 3080 877900
SGTC_3141 9094609 49.47 µM -0.339576010384232 0.362919186669525 no 2174 0.367087923313444 2953 25236309 YDL196W YDL196W
SGTC_1226 3909-7979 35.4 µM -0.340324354027253 0.362644360147337 no 2175 0.36680613935536 3119 6615510
SGTC_1973 st070275 50.2 µM -0.340376539925329 0.362625197700525 no 2176 0.366786491767807 3047 17118334
SGTC_332 4112-0506 40.9 µM -0.34131058062234 0.362282280039492 no 2177 0.366434891728195 3006 2790355
SGTC_2200 6600604 21.907 µM -0.34324908279853 0.361570943751765 no 2178 0.365705541188359 3006 2904777
SGTC_3128 9127691 49.47 µM -0.343607951155125 0.36143930885018 no 2179 0.365570572135316 3119 41316314
SGTC_259 usnic acid 108.925 µM -0.344870485071458 0.360976334847988 no 2180 0.365095870194615 3219 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_232 clozapine 119 µM -0.345703458840054 0.360670992947379 no 2181 0.364782792293095 3014 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2708 st078559 56 µM -0.346593827190502 0.360344710199148 no 2182 0.364448241990336 3116 17250902
SGTC_1115 galangin 695.678 nM -0.346748551838803 0.360288020452759 no 2183 0.364390115698798 3180 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.348313715934408 0.359714731020237 no 2184 0.36380229710671 3128 1273210
SGTC_2658 polymyxin b sulfate 77.05 µM -0.349617633781927 0.359237371895438 no 2185 0.363312837654414 3034 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2518 prenyletin 46.28 µM -0.349999853179856 0.35909748449504 no 2186 0.363169403917224 3121 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2715 st079500 56.4 µM -0.351770846371643 0.358449570486022 no 2187 0.362505062047278 2989 28246688
SGTC_1657 st012939 43.4 µM -0.352466011572341 0.358195357012037 no 2188 0.362244401944263 3158 24207257
SGTC_1172 0370-0043 85 µM -0.352546656369853 0.358165870255039 no 2189 0.362214167391417 3162 376585
SGTC_1466 k213-0079 57.5 µM -0.353241795467618 0.357911736467652 no 2190 0.361953588347155 3027 3657981
SGTC_1615 st002656 86.5 µM -0.35378569877858 0.357712936407402 no 2191 0.361749745984069 3052 1584458
SGTC_1425 4048-4433 7.33 µM -0.355163043978946 0.357209680840036 no 2192 0.361233724440773 3120 23734946
SGTC_1129 3453-1384 223 µM -0.355241761711596 0.357180926380031 no 2193 0.361204240505657 3225 1084452
SGTC_2158 5657123 3.6195 µM -0.355890267727627 0.356944067301903 no 2194 0.360961372250462 3029 2858827
SGTC_255 tunicamycin 200.472 nM -0.35598683517832 0.35690880190766 no 2195 0.360925212122461 3100 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1505 k297-0037 20.6 µM -0.357291744723866 0.35643238298528 no 2196 0.36043670472387 3059 4089396
SGTC_656 4090-1979 187 µM -0.35844967197047 0.356009814404258 no 2197 0.360003412437935 3165 22330961
SGTC_11 0438-0307 1.3 µM -0.358891749686834 0.355848531229716 no 2198 0.359838035917576 3138 4011476
SGTC_1028 k015-0029 4.8 µM -0.358909480603257 0.355842062998935 no 2199 0.359831403519448 3020 4588309
SGTC_2765 myclobutanil 7.74 µM -0.358944039260679 0.355829456134653 no 2200 0.359818476684842 3129 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2411 st077133 39.94 µM -0.360129272357367 0.355397183207045 no 2201 0.359375231601463 3307 1403142 YNL221C POP1
SGTC_2824 7998404 51.95 µM -0.360199220968376 0.355371677667741 no 2202 0.359349078620773 3012 837851
SGTC_2015 5119600 184 µM -0.361202597161554 0.3550058854039 no 2203 0.358974000381219 3209 2828786
SGTC_1783 st039459 87.517 µM -0.362197315924034 0.354643381172587 no 2204 0.358602292586288 3233 729761
SGTC_268 camptothecin 39.6153 µM -0.363951934966116 0.354004268311082 no 2205 0.357946950868655 3145 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.364745690351589 0.353715281079836 no 2206 0.357650624409117 3080 229346 A bile salt which induces apoptosis.
SGTC_2764 methyldopa 94.69 µM -0.365116785993842 0.35358020298921 no 2207 0.357512115606177 3223 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_916 4466-0038 42 nM -0.365695695574236 0.353369517847895 no 2208 0.357296079209949 3271 5722064 YGL116W CDC20
SGTC_339 3091-4833 71.4 µM -0.367281929448982 0.352792463044741 no 2209 0.356704365923271 3040 3240077
SGTC_1033 k072-0102 21.3 µM -0.368602900561918 0.352312166224481 no 2210 0.356211866627718 3213 5965931
SGTC_2979 9012552 45.46 µM -0.369667055570227 0.351925417312168 no 2211 0.355815290725302 3159 17100905
SGTC_2026 5148700 152 µM -0.370399211332487 0.351659416743874 no 2212 0.355542530675868 3028 79838
SGTC_2910 7948405 25.97 µM -0.37403250320202 0.350340476669819 no 2213 0.354190067155718 3222 2971328
SGTC_3011 9081274 71.4286 µM -0.374497932616424 0.350171648655988 no 2214 0.354016947209732 3064 6625322
SGTC_2236 dapsone 200 µM -0.375394324841062 0.349846578348441 no 2215 0.353683612471101 3129 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2581 avocatin a 64 µM -0.376003343163733 0.34962578491367 no 2216 0.353457205304521 3089 6710728 A skin care supplement.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.376037999516677 0.349613222131999 no 2217 0.353444323101487 3016 88881 An O-methylated flavonoid and antioxidant.
SGTC_513 4245-1575 41.7 µM -0.376142649816982 0.349575287839381 no 2218 0.353405424285269 3143 719745
SGTC_928 2764-0428 58.7 µM -0.37979793347265 0.34825124273616 no 2219 0.352047708230278 3175 662578
SGTC_2251 lansoprazole 556 µM -0.380155256825048 0.34812190917361 no 2220 0.351915085102965 3028 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1659 st012954 42.1 µM -0.380506732913274 0.347994709265768 no 2221 0.351784649803968 3185 24207262
SGTC_1770 st043884 66.3 µM -0.380517655414056 0.347990756664547 no 2222 0.351780596664917 3049 670149
SGTC_1318 1280-3875 124 µM -0.38100415392789 0.347814720824983 no 2223 0.351600083109916 3130 373245
SGTC_2652 actinonin 100 µM -0.381138694052974 0.347766044277705 no 2224 0.351550168375733 3050 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1441 4106-0040 13 µM -0.381473380812316 0.347644965668793 no 2225 0.351426009827536 3091 2904180
SGTC_712 r015-0009 80.6 µM -0.381512081213919 0.347630966144523 no 2226 0.351411654184725 3170 6813872 YLR060W FRS1
SGTC_1165 k072-0275 30.3 µM -0.382891434771567 0.347132133136636 no 2227 0.350900131190383 3215 6153523 YGL055W OLE1
SGTC_236 1509-0011 5.31 µM -0.383935293149975 0.346754805410142 no 2228 0.350513203576768 3221 3107280
SGTC_327 1273-0057 3.96 µM -0.385541048656403 0.346174663203879 no 2229 0.349918300027394 3098 3108138
SGTC_2807 7945238 51.95 µM -0.386786416358273 0.345724973569554 no 2230 0.349457167119077 3155 17148797
SGTC_182 3448-4371 550.524 µM -0.389633705109933 0.344697664729548 no 2231 0.348403712496237 3155 3491403
SGTC_91 0417-1751 58.384 µM -0.389802357651581 0.344636850294582 no 2232 0.348341350127662 3166 6795624
SGTC_3002 9075603 71.4286 µM -0.392194970452281 0.343774530994273 no 2233 0.347457080029449 3138 20105405
SGTC_416 estradiol valerate 100 µM -0.392257741998279 0.343751918475175 no 2234 0.347433891851191 3150 13791 A steroid.
SGTC_1171 0368-0077 21.4 µM -0.394728323791993 0.342862372684914 no 2235 0.346521698647052 3078 3239779
SGTC_954 1189-0853 2.85 µM -0.396036033710981 0.342391876904308 no 2236 0.346039222923327 3139 2828194
SGTC_1761 st044296 37 µM -0.396419726527267 0.34225387594219 no 2237 0.345897707958498 3065 1826700
SGTC_2795 7780010 54.55 µM -0.39951667186413 0.341140784892723 no 2238 0.344756270910292 3243 953673
SGTC_1181 1222-0449 220 µM -0.399887953110618 0.341007433068273 no 2239 0.344619522837966 3270 658318
SGTC_2929 9013348 24.6 µM -0.40098443684631 0.340613728709925 no 2240 0.344215791122627 3193 2995952
SGTC_1631 benzylvanillin 81.9 µM -0.403224712139967 0.33980987363997 no 2241 0.343391460835634 3239 75506
SGTC_2557 derrustone 83.84 µM -0.403648223808844 0.339657990981683 no 2242 0.343235709297102 3225 629853 An antioxidant.
SGTC_3282 9108498 15.4605 µM -0.404924237540013 0.339200535650094 no 2243 0.342766600857212 3192 16459645
SGTC_1573 oleylamine 1.06 µM -0.406480339026041 0.338642988563071 no 2244 0.342194850113228 3116 5356789 An amine of the fatty acid oleic acid.
SGTC_3252 9135871 49.47 µM -0.406741358158489 0.338549500672937 no 2245 0.342098980508664 3249 17682838
SGTC_753 1322-0200 289 µM -0.409090094025516 0.337708714056097 no 2246 0.341236772812155 3248 5403907
SGTC_945 3381-0768 11.3 µM -0.409353127190402 0.337614605310972 no 2247 0.341140266305982 3266 1126236 YIL048W NEO1
SGTC_1608 st001473 40.5 µM -0.410453426494002 0.337221047264979 no 2248 0.340736680712581 3123 7292267
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.410615004975375 0.337163268418446 no 2249 0.340677429676163 3195 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_684 1140-0066 328 µM -0.410970327799286 0.33703622204715 no 2250 0.340547146169758 3197 6813534
SGTC_3069 9117009 49.47 µM -0.411543516187747 0.33683131659645 no 2251 0.340337019662294 3138 41904981
SGTC_51 1013-0126 23.419 µM -0.412887639103788 0.33635100468567 no 2252 0.339844468895359 3386 1627850
SGTC_2393 9031399 185.94 µM -0.413173108362504 0.336249028801839 no 2253 0.339739894496675 3267 1526623 YDL150W RPC53
SGTC_1736 st036774 51 µM -0.413339501044293 0.336189595241542 no 2254 0.339678946461001 3345 1272247
SGTC_328 k915-0120 63.5 µM -0.413781990042858 0.336031563163614 no 2255 0.339516887404185 3230 6624543
SGTC_649 1123-0311 367 µM -0.416543448159023 0.335045981995292 no 2256 0.338506190592691 3216 693629 YIL048W NEO1
SGTC_756 0508-1999 28.3 µM -0.416655474713286 0.335006022944528 no 2257 0.338465213227508 3126 6753853
SGTC_2638 epoxomicin 18 µM -0.417120099790517 0.334840314524665 no 2258 0.338295281876036 3239 9915668 A protesome inhibitor.
SGTC_3152 9099253 49.47 µM -0.418763805486335 0.334254345555997 no 2259 0.337694379684486 3176 25236131
SGTC_2223 6903751 107.57 µM -0.41982597898115 0.333875903149363 no 2260 0.337306292553309 3207 5598863
SGTC_2475 5812728 15.03 µM -0.419868234396467 0.333860851433876 no 2261 0.337290857236409 3129 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_218 alverine citrate 93.75 µM -0.419934840835876 0.333837126232424 no 2262 0.337266527384338 3267 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_622 1348-1566 26.3 µM -0.420656802356224 0.333580006309743 no 2263 0.337002854568222 3201 7340407
SGTC_88 0180-0332 8.668 µM -0.420971105816986 0.333468094446697 no 2264 0.336888090524573 3127 3101745
SGTC_318 1488-0629 67.2 µM -0.421370740229157 0.333325820782682 no 2265 0.33674219086128 3239 3662576
SGTC_1346 1488-2224 62.4 µM -0.423793580114786 0.332463780613419 no 2266 0.335858180253406 3253 3722427
SGTC_2737 bleomycin 30.5 nM -0.424427924447621 0.332238228600279 no 2267 0.335626879597105 3214 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3257 9139206 32.98 µM -0.425062072995842 0.33201280692399 no 2268 0.335395712566307 3248 4910041
SGTC_1886 st057356 49.9 µM -0.425205840755633 0.331961710045857 no 2269 0.335343313370508 3140 24207747
SGTC_2789 5281112 71.43 µM -0.426005976611647 0.331677388769325 no 2270 0.335051745507918 3172 765948
SGTC_690 glyoxal 20.3 µM -0.426966796612357 0.331336097889305 no 2271 0.334701755990563 3218 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3323 9138564 53.9225 µM -0.428375359298613 0.330836018427274 no 2272 0.334188930703674 3303 43912313 YNL103W MET4
SGTC_530 4358-1714 28 µM -0.428638809666814 0.330742519587622 no 2273 0.334093048796755 3219 1564641
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.429319714635196 0.330500914553414 no 2274 0.333845285808518 3276 5024745
SGTC_3007 9078383 71.4286 µM -0.430988130337703 0.329909210475287 no 2275 0.333238500553411 3164 6496995
SGTC_3274 9138298 49.47 µM -0.431514267544823 0.329722703914988 no 2276 0.33304724037574 3165 17015756
SGTC_2762 leflunomide 42.06 µM -0.433258692723335 0.329104638364194 no 2277 0.332413421835473 3175 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3093 9117344 49.47 µM -0.433678907290679 0.328955822271147 no 2278 0.332260812801723 3285 24824913
SGTC_1329 1447-1697 50.6 µM -0.433693836870947 0.328950535561721 no 2279 0.332255391347805 3237 2840515
SGTC_2748 diazoxide 86.69 µM -0.435542741014268 0.328296085445195 no 2280 0.33158426111195 3208 3019 A potassium channel activatior.
SGTC_116 0155-0182 31.788 µM -0.437369538493843 0.327649977452938 no 2281 0.330921685902652 3181 771486
SGTC_1279 0874-0590 65.2 µM -0.437438717536389 0.327625520095197 no 2282 0.330896605212224 3214 3523074
SGTC_830 4076-0286 57.8 µM -0.438467354623132 0.327261946032982 no 2283 0.330523764982812 3173 6866659
SGTC_648 0375-0473 33.3 µM -0.439119275236133 0.327031608034079 no 2284 0.330287556583997 3181 1713139
SGTC_293 4049-0273 38.5 µM -0.44011006873012 0.326681664894697 no 2285 0.329928694899227 3197 1380311
SGTC_1784 st039334 36.3 µM -0.440354292879726 0.326595429592659 no 2286 0.32984026185283 3366 3496984
SGTC_2315 7733312 200 µM -0.441129878023839 0.326321632703781 no 2287 0.32955948719371 3146 726316
SGTC_1965 Pectolinarigenin 58.4 µM -0.442955788765079 0.325677419745858 no 2288 0.328898856748183 3184 5320438 An anti-inflammatory.
SGTC_3026 9090633 49.47 µM -0.442972173382393 0.325671641321309 no 2289 0.328892931065812 3165 25236842
SGTC_3064 1327-0027 10 µM -0.442985030640032 0.325667106933282 no 2290 0.328888281123123 3189 16000455 YPR107C YTH1
SGTC_791 1348-1292 225 µM -0.443061259128489 0.325640223849584 no 2291 0.328860712949707 3210 5437054
SGTC_1692 fluoroquinolonic acid 71 µM -0.443674800803053 0.325423882498195 no 2292 0.328638858387888 3289 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3215 9129942 49.47 µM -0.444233535694255 0.325226917764738 no 2293 0.328436874302356 3296 17682944
SGTC_186 3455-3465 67.277 µM -0.445118486989774 0.324915055419127 no 2294 0.32811706474887 3135 755278
SGTC_496 calpeptin 138 µM -0.445160388641142 0.324900292055965 no 2295 0.328101925174336 3228 73364 A calpain inhibitor.
SGTC_1640 st009078 66.4 µM -0.4454070372135 0.32481339503002 no 2296 0.328012813779739 3273 690618
SGTC_1467 k284-1082 293 µM -0.447144711672691 0.324201463423061 no 2297 0.327385288931788 3263 3334705
SGTC_2787 5284540 71.43 µM -0.447577156065082 0.324049249439964 no 2298 0.327229196350098 3209 736958
SGTC_1780 st038448 24.544 µM -0.447814788490131 0.323965618886461 no 2299 0.327143434808716 3343 728868 YDL195W SEC31
SGTC_471 1-acyl-paf 4 µM -0.447907761607956 0.323932901050242 no 2300 0.327109883294303 3179 16759367
SGTC_1259 0671-0132 43 µM -0.450375434982118 0.323065008788657 no 2301 0.326219877290528 3170 X1259
SGTC_1755 st041960 45.185 µM -0.452464185450792 0.322331137246925 no 2302 0.325467308277702 3300 2257073
SGTC_596 1155-0152 116 µM -0.452507686533656 0.322315860714804 no 2303 0.325451642547501 3229 280313
SGTC_2183 6420625 130.508 µM -0.453464375831953 0.321979970393616 no 2304 0.325107194959062 3289 2897619
SGTC_2426 5582046 32.21 µM -0.455069952542915 0.321416584763286 no 2305 0.32452945703584 3349 2251934
SGTC_1093 fluphenazine 7.97 µM -0.457700104347395 0.320494570512792 no 2306 0.323583956518423 3224 6602611 An atypical antipsychotic.
SGTC_466 geldanamycin 89.2 µM -0.457741035037392 0.32048023076437 no 2307 0.323569251518671 3213 5288382 HSP90 inhibitor.
SGTC_299 1273-0059 1.44 µM -0.457775263804424 0.320468239188212 no 2308 0.323556954502603 3277 2848077
SGTC_3192 9110362 49.47 µM -0.45782661311254 0.320450250018242 no 2309 0.323538507127685 3310 16649480
SGTC_2634 4'-methoxyflavone 100 µM -0.45848037217329 0.320221255914263 no 2310 0.323303680375797 3252 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_313 3474-0040 5.03 µM -0.459169969791637 0.319979782716516 no 2311 0.323056056875647 3171 1043375 YIL048W NEO1
SGTC_3202 9113761 49.47 µM -0.45955788923714 0.319843980268247 no 2312 0.322916795640983 3318 4798415
SGTC_3036 9090181 49.47 µM -0.459893646684211 0.319726458130689 no 2313 0.322796280356413 3246 25236586
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.4607448955455 0.319428584326126 no 2314 0.322490820292282 3225 91467 include heat shock
SGTC_1747 st037496 66.6 µM -0.460777318259006 0.319417241089045 no 2315 0.322479188171792 3193 723305
SGTC_1008 4106-0037 6 µM -0.4618945070296 0.319026490695663 no 2316 0.322078486657662 3151 2905394
SGTC_1725 st036284 20.55 µM -0.462708451232423 0.318741930336549 no 2317 0.321786679859532 3376 707914
SGTC_1808 st050063 61.5 µM -0.465101681110667 0.317905860502515 no 2318 0.320929321085581 3343 4011993
SGTC_2733 amorolfine 100 µM -0.466440849228771 0.317438429273144 no 2319 0.320449988895111 3281 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2710 st078562 53.7235 µM -0.468202695706666 0.316823907139569 no 2320 0.319819822301057 3204 17250908
SGTC_2799 7812892 81.82 µM -0.4685227754024 0.316712319307566 no 2321 0.319705393860835 3349 20205235
SGTC_311 1315-0136 58 µM -0.46886094667444 0.316594442413475 no 2322 0.319584516326283 3381 6759207
SGTC_2138 5575593 77.673 µM -0.470955384552106 0.315864796151435 no 2323 0.31883629788995 3243 762213
SGTC_1932 st074806 40.9 µM -0.471402322259141 0.315709187696574 no 2324 0.318676728969599 3429 17251235
SGTC_702 1488-0190 94 µM -0.471693616238291 0.315607786654737 no 2325 0.318572747187128 3322 949357
SGTC_971 1315-0384 26.7 µM -0.471726763376221 0.315596248832579 no 2326 0.318560915721145 3240 6769120
SGTC_373 0844-0104 25.9 µM -0.471912452706511 0.315531617602914 no 2327 0.318494639604253 3336 5375804
SGTC_3171 9103192 49.47 µM -0.472240574284003 0.31541742504617 no 2328 0.318377540859769 3358 13018434
SGTC_1559 coumarin 343 70.1 µM -0.473352260559103 0.31503066813877 no 2329 0.31798094153682 3367 108770 A hepatotoxic, DNA x-linker.
SGTC_2942 9052777 62.25 µM -0.475279888407427 0.314360524882649 no 2330 0.31729374597702 3277 6469503
SGTC_1652 st011932 78 µM -0.475529408747264 0.314273823335576 no 2331 0.317204838423169 3305 1551076
SGTC_1139 k015-0024 46.9 µM -0.47563572712624 0.314236883696678 no 2332 0.317166958916504 3335 2766652
SGTC_1241 0364-0022 50.8 µM -0.475723449902953 0.31420640638135 no 2333 0.317135706162251 3249 4563895
SGTC_1022 4477-0945 21.3 µM -0.476361515727093 0.313984762819892 no 2334 0.316908423447588 3243 4648966
SGTC_718 1130-0073 349 µM -0.476953846388831 0.313779066228061 no 2335 0.316697493682279 3413 6740020
SGTC_1915 st067105 30.6 µM -0.476964154476294 0.313775487086796 no 2336 0.316693823485421 3316 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2991 9074669 71.4286 µM -0.479704616555019 0.312824575112911 no 2337 0.315718722383089 3383 17333109
SGTC_2050 5263056 171 µM -0.480549294452539 0.312531731167659 no 2338 0.315418430223654 3363 763468 YGL055W OLE1
SGTC_1437 4092-1038 11.6 µM -0.481333641499237 0.312259909454614 no 2339 0.315139695453994 3251 3977136
SGTC_107 0358-0022 2.6945 µM -0.482918524735464 0.311710967414392 no 2340 0.314576793973799 3301 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_714 4296-0578 26.1 µM -0.483393626351979 0.311546492055886 no 2341 0.31440813643294 3246 1589775
SGTC_1062 mesoridazine 14.2 µM -0.48552046471045 0.310810663442642 no 2342 0.313653599803265 3315 4078 A neuroleptic.
SGTC_2182 6325192 200 µM -0.486045128939506 0.310629259926346 no 2343 0.313467584770927 3337 736248
SGTC_547 1120-0019 610 nM -0.486818534981405 0.310361937472839 no 2344 0.313193467043716 3288 3676939
SGTC_1455 4262-0120 131 µM -0.490276321921975 0.309168003660596 no 2345 0.311969189922757 3430 1529587
SGTC_1457 k015-0032 57.3 µM -0.490586497007567 0.30906100197784 no 2346 0.311859469347355 3336 4302660
SGTC_2843 9000894 45.46 µM -0.490802642645235 0.308986447386527 no 2347 0.311783020388485 3274 2242070
SGTC_3175 9106517 49.47 µM -0.49175325173037 0.308658649525726 no 2348 0.311446893965214 3341 41468073
SGTC_1341 1486-1360 280 µM -0.4958771360798 0.30723838074152 no 2349 0.309990549171535 3242 3976547
SGTC_1376 2910-0861 41.3 µM -0.496480173987848 0.307030935450571 no 2350 0.309777835948668 3316 1112859
SGTC_2670 beta-carotene 100 µM -0.496673881660381 0.306964313032361 no 2351 0.309709521774485 3331 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_846 0335-0850 148 µM -0.498859238755346 0.306213139081953 no 2352 0.308939275679821 3337 6819598
SGTC_3196 9111891 49.47 µM -0.500010506202741 0.305817740430055 no 2353 0.308533839866001 3353 18891510
SGTC_1612 st002233 45.4 µM -0.500613452800831 0.305610750835994 no 2354 0.308321596398052 3389 1035021
SGTC_1935 st074532 41.6 µM -0.501297631182939 0.305375949856232 no 2355 0.308080836081656 3361 2829742
SGTC_1610 st001799 48.1 µM -0.502034269520729 0.305123234798513 no 2356 0.307821707566377 3210 621897
SGTC_1751 st044839 27.194 µM -0.502768869791716 0.304871311430258 no 2357 0.307563391400537 3383 5291326
SGTC_531 3788-1495 174 µM -0.503908101977022 0.304480806770235 no 2358 0.307162978444944 3231 2896655
SGTC_3054 9094397 49.47 µM -0.505328632901836 0.303994190941802 no 2359 0.306664017649123 3316 2598354
SGTC_1108 betulinic acid 729.144 nM -0.505408167565107 0.303966955869584 no 2360 0.306636091714897 3317 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_323 4013-0906 34.3 µM -0.507207768222204 0.303351009266804 no 2361 0.306004522493915 3371 2910086
SGTC_234 nsc-17383 10.7 µM -0.507896192785102 0.303115530820589 no 2362 0.305763072426743 3421 408974
SGTC_609 0986-0026 86.3 µM -0.508102523257788 0.303044970563844 no 2363 0.305690722900038 3320 2848610
SGTC_1501 4491-0275 38.4 µM -0.508225645143712 0.303002869223462 no 2364 0.305647553975143 3374 5104718
SGTC_2930 9013230 14.89 µM -0.508384817621576 0.302948444317786 no 2365 0.305591749015796 3386 2995857
SGTC_3302 9125395 16.351 µM -0.509484925036365 0.302572410767108 no 2366 0.305206181166211 3283 17599668
SGTC_3122 9126309 49.47 µM -0.509753885828419 0.30248050768658 no 2367 0.305111948102962 3401 17591206
SGTC_1003 4049-0218 100 µM -0.51054164912419 0.302211403416304 no 2368 0.304836021821471 3439 295161
SGTC_1916 st067606 49.2 µM -0.512518148067828 0.301536693994474 no 2369 0.304144211181638 3328 19590279
SGTC_748 act1.228 77.9 µM -0.514205056390475 0.300961377593134 no 2370 0.30355431647963 3352 4421505 YNR035C ARC35
SGTC_227 fluconazole 33.516 µM -0.514251683576841 0.300945482524041 no 2371 0.303538018684543 3340 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1098 clofazimine 15.1 µM -0.514905800838516 0.300722535810802 no 2372 0.303309423554599 3424 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_639 0833-0042 114 µM -0.515291496760135 0.300591111695326 no 2373 0.303174670019434 3295 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2058 5236698 133 µM -0.515938273940826 0.300370783562661 no 2374 0.302948760639354 3298 766665
SGTC_2054 5233173 129 µM -0.516428352995493 0.300203884102685 no 2375 0.302777633708464 3396 6889
SGTC_2190 6049624 200 µM -0.516483845692899 0.300184988363546 no 2376 0.302758259369644 3335 2265554
SGTC_844 0330-0132 15.3 µM -0.516924258290307 0.300035043173515 no 2377 0.302604516438227 3422 2828079
SGTC_843 0310-0051 143 µM -0.517193495019781 0.299943394112649 no 2378 0.302510546253196 3346 2065037
SGTC_3012 9080433 71.4286 µM -0.517495217402612 0.299840701887025 no 2379 0.302405253330606 3402 17688859
SGTC_2021 4019055 173 µM -0.517925483652471 0.29969428686592 no 2380 0.302255130525415 3454 44827708 YER133W GLC7
SGTC_3345 9148410 3.559 µM -0.518746638496954 0.299414946543397 no 2381 0.301968716900626 3392 4903596
SGTC_1405 3909-7894 12 µM -0.518957871368381 0.299343108474839 no 2382 0.301895059927685 3394 7104060
SGTC_2545 solidagenone 89.61 µM -0.519888167512981 0.299026817653643 no 2383 0.301570761464506 3275 6708572 An anti ulcer agent
SGTC_1250 0485-0349 40.2 µM -0.521067972737755 0.298625914803114 no 2384 0.301159710440064 3298 6842794 YDL195W SEC31
SGTC_3063 1327-0034 4 µM -0.521609309369793 0.298442048144066 no 2385 0.300971190121046 3364 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_59 0330-0160 1.33 µM -0.522248663985027 0.29822495575007 no 2386 0.300748603624474 3403 4293482
SGTC_803 4488-1585 147 µM -0.522436185029253 0.298161296758302 no 2387 0.300683333675133 3395 747204
SGTC_731 3966-0296 387 µM -0.522502855069511 0.29813866533658 no 2388 0.300660129552852 3370 660956
SGTC_956 1185-0240 191 µM -0.523795809491394 0.297699921429056 no 2389 0.300210284168891 3307 1416193
SGTC_2270 7924575 90.91 µM -0.524404072364485 0.297493618859537 no 2390 0.2999987623349 3418 1262135
SGTC_3354 9151612 71.43 µM -0.525429228483644 0.297146067749238 no 2391 0.299642419644445 3411 27261949
SGTC_1891 st059073 26.2 µM -0.525959246263012 0.296966452560519 no 2392 0.299458261513714 3435 688754
SGTC_23 0213-0011 39.996 µM -0.526030698572751 0.296942242228988 no 2393 0.299433438868707 3456 627608
SGTC_737 1950-0117 57.9 µM -0.52642217990838 0.296809611841706 no 2394 0.299297454197211 3415 5393513
SGTC_1230 0170-0365 3.77 µM -0.527142888665496 0.296565513076396 no 2395 0.299047182618111 3483 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3338 9144300 39.5675 µM -0.528860021041088 0.295984303870919 no 2396 0.298451278627222 3338 4901274
SGTC_425 3825-7017 13.1 µM -0.529399716353747 0.295801737677516 no 2397 0.298264097453065 3469 3397440
SGTC_1742 st038235 28.8875 µM -0.529645323752758 0.295718671619334 no 2398 0.29817893175589 3385 564103 YBR002C RER2
SGTC_2246 7293507 91.5585 µM -0.530849732043489 0.295311487963562 no 2399 0.297761457081122 3411 887656
SGTC_502 l-744,832 89.3 µM -0.533334023441086 0.294472420309702 no 2400 0.296901189789421 3412 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2088 5278280 127.392 µM -0.534093166757699 0.294216239869024 no 2401 0.296638538585446 3446 791502
SGTC_1929 genistein trimethyl ether 50.5 µM -0.535033061062128 0.293899205943375 no 2402 0.29631349801523 3466 136420
SGTC_273 hydroxyurea 18.1 mM -0.535307971792984 0.293806506211615 no 2403 0.296218457416666 3400 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2964 9083345 53.42 µM -0.535373998658553 0.29378424400735 no 2404 0.296195633061047 3338 17741579
SGTC_1909 st060837 51.5 µM -0.537293386407824 0.29313742758871 no 2405 0.295532486531158 3328 678937
SGTC_3006 9075424 71.4286 µM -0.538062927390781 0.292878284788654 no 2406 0.29526680276298 3342 7465181
SGTC_1949 st076024 69.1 µM -0.538416360670876 0.292759301833532 no 2407 0.295144816891251 3290 2921930
SGTC_3219 9131112 49.47 µM -0.538454212091087 0.292746560522079 no 2408 0.295131754023413 3393 17612988 YMR079W SEC14
SGTC_1036 k216-0215 33.5 µM -0.539780340143888 0.292300330122507 no 2409 0.294674263380006 3421 622330
SGTC_741 4582-0002 126 µM -0.540494373076042 0.292060195433542 no 2410 0.294428070238861 3361 2912688
SGTC_1305 1181-0477 144 µM -0.540600683196436 0.292024450389512 no 2411 0.294391423437907 3457 6252086
SGTC_2266 7929956 200 µM -0.540905619621746 0.291921931791195 no 2412 0.294286318654269 3434 2967153
SGTC_3099 9120367 49.47 µM -0.541563884773893 0.291700682429605 no 2413 0.29405948844916 3430 24824940
SGTC_569 4130-2812 160 µM -0.543363950869413 0.291096062014119 no 2414 0.29343962049178 3377 743552
SGTC_2346 9031566 143.75 µM -0.544046713901935 0.290866883383925 no 2415 0.293204663717655 3348 4771086
SGTC_2928 9011484 9.79 µM -0.544435275437635 0.290736495125569 no 2416 0.293070988396607 3424 2994751
SGTC_2563 tomatine 8.54 µM -0.545336368367041 0.290434223709566 no 2417 0.292761097727139 3497 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1487 3970-0795 2.82 µM -0.546993632235025 0.289878679354435 no 2418 0.29219155344737 3446 3765103
SGTC_1660 st012960 28.1 µM -0.552361329643591 0.288082761665371 no 2419 0.290350409680225 3406 24207266
SGTC_837 0091-0265 12.5 µM -0.5526927753812 0.287972039292339 no 2420 0.290236900638048 3363 759367
SGTC_3158 9100007 49.47 µM -0.552787583119436 0.287940371626516 no 2421 0.290204435993194 3363 19297233
SGTC_346 4513-0042 7.16 µM -0.552867711868078 0.287913608316625 no 2422 0.290176999144253 3422 2827372
SGTC_806 3966-4455 5.86 µM -0.553054059511742 0.287851372030384 no 2423 0.290113196631373 3357 714982
SGTC_2996 9066192 71.4286 µM -0.554055554697479 0.28751700208666 no 2424 0.289770413038453 3395 6472854
SGTC_2941 9056145 11.23 µM -0.554459052407823 0.287382337926172 no 2425 0.289632360863092 3417 2119517
SGTC_433 pimozide 108 µM -0.554732945808731 0.287290945179448 no 2426 0.289538668930579 3289 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_207 4185-0010 4.486 µM -0.555738222821546 0.28695562228701 no 2427 0.289194911392472 3500 3761753
SGTC_2081 5214970 32.255 µM -0.556170148783532 0.286811604874303 no 2428 0.289047271946981 3428 2063512
SGTC_1123 mangostin 811.285 nM -0.556219266513698 0.286795229680569 no 2429 0.289030484938826 3398 5281650 An antioxidant.
SGTC_561 1550-0330 72.9 µM -0.558759842925354 0.285948840378667 no 2430 0.288162815989071 3370 6812934
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.559951437971233 0.285552271702055 no 2431 0.287756280949619 3429 2333 A French combination drug.
SGTC_2814 7977482 42.97 µM -0.561360294410105 0.285083735368091 no 2432 0.287275972967296 3489 6456762
SGTC_802 4112-3352 742 µM -0.561402542795907 0.285069690695748 no 2433 0.287261575489109 3490 704594
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.56170016776051 0.284970760285046 no 2434 0.287160160014624 3421 77254
SGTC_1282 0886-0010 32.4 µM -0.562371631826263 0.284747626076638 no 2435 0.286931421434776 3518 2836211 YNL267W PIK1
SGTC_1729 st035615 45.989 µM -0.562374481239284 0.284746679365966 no 2436 0.286930450947751 3403 17385451
SGTC_1961 st076550 68.7 µM -0.562516130604182 0.284699618596371 no 2437 0.286882208280227 3447 1579337
SGTC_256 clotrimazole 625 nM -0.56282819971897 0.284595951651928 no 2438 0.286775937946438 3439 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3092 9117248 49.47 µM -0.565526100514946 0.283700482227744 no 2439 0.285857988244395 3475 17141857
SGTC_2011 4012611 177 µM -0.565527579008432 0.283699991866125 no 2440 0.285857485576302 3404 2049887
SGTC_2967 9089538 49.85 µM -0.565708417096942 0.283640017620475 no 2441 0.285796006204647 3507 728216
SGTC_345 1362-0200 395 µM -0.566951163794561 0.283228029899503 no 2442 0.285373680851939 3396 1419823
SGTC_3140 9094243 49.47 µM -0.567618218246872 0.283007010574049 no 2443 0.285147116918005 3514 19291112
SGTC_2180 6301957 200 µM -0.567724541166869 0.282971789587238 no 2444 0.285111012438376 3455 845462
SGTC_1844 rapamycin 4 nM -0.567928774467978 0.282904140291523 no 2445 0.285041666270865 3443 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.569997022666409 0.282219501220777 no 2446 0.28433985873339 3367 6708514
SGTC_2614 arthonioic acid 13.39 µM -0.570248704855662 0.282136242917358 no 2447 0.28425451316177 3445 6710684
SGTC_449 xestospongin c 11.1929 µM -0.571589896073756 0.281692766597383 no 2448 0.283799921095467 3458 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1443 4112-3303 14 µM -0.571815226787448 0.28161829206238 no 2449 0.283723580204546 3458 704433
SGTC_1477 0139-0234 16 µM -0.572140827157838 0.281510693965322 no 2450 0.283613285843205 3465 620880
SGTC_2379 9035213 200 µM -0.572356329639898 0.281439489792166 no 2451 0.283540297505208 3486 646551
SGTC_1387 3342-1166 1.8 µM -0.573810195501695 0.280959345200564 no 2452 0.283048124351033 3420 3418228
SGTC_2682 pyrogallin 40.03 µM -0.573830604865099 0.280952607751285 no 2453 0.283041218145729 3456 822798 An ATP competetive kinase inhibitor.
SGTC_699 0375-0592 111 µM -0.573933741612072 0.280918561896359 no 2454 0.283006319541313 3514 762578
SGTC_228 caffeine 993.056 µM -0.574827702286774 0.280623545464473 no 2455 0.28270391470908 3499 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_4 0960-0234 25.671 µM -0.576387282056 0.280109226870433 no 2456 0.28217671939662 3484 6821112
SGTC_1803 st050068 52.4 µM -0.576639674451945 0.280026035811768 no 2457 0.28209144599597 3553 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_384 k007-0144 5.16 µM -0.577034161332272 0.279896032984253 no 2458 0.281958189350923 3453 6824886
SGTC_1360 1598-0022 39.8 µM -0.577457892664604 0.279756425284656 no 2459 0.281815087792322 3481 761525
SGTC_1908 st060353 56.5 µM -0.577604949549319 0.279707982026019 no 2460 0.2817654322666 3547 4227716
SGTC_813 k007-0158 173 µM -0.577934218223428 0.279599529596071 no 2461 0.281654266033795 3454 6523916
SGTC_1980 st071811 45.7 µM -0.578521961163528 0.279405993303011 no 2462 0.281455887444738 3546 4974850
SGTC_2836 9010338 19.48 µM -0.57881996330922 0.279307889844389 no 2463 0.28135532970273 3373 2994051
SGTC_1769 st044406 64.4 µM -0.580883809147914 0.278628923535017 no 2464 0.280659382584936 3406 670903
SGTC_3040 9091894 49.47 µM -0.58240805654293 0.278127991460785 no 2465 0.280145928061803 3430 25236966
SGTC_2602 kawain 100 µM -0.58535724188451 0.277160013573662 no 2466 0.279153766449429 3503 5369129
SGTC_672 1441-0018 53.7 µM -0.585498336243399 0.277113745108471 no 2467 0.279106342493676 3434 251141
SGTC_2810 7959871 45.46 µM -0.586260116954637 0.276864002954495 no 2468 0.2788503641232 3453 2974535
SGTC_771 0250-0039 27.3 µM -0.586637390962471 0.276740358287005 no 2469 0.278723632439204 3405 3005115
SGTC_468 gf-109203x 121 µM -0.586882188476581 0.276660144845844 no 2470 0.278641416488103 3423 2396 A protein kinase C inhibitor.
SGTC_988 1497-1057 103 µM -0.587357201789361 0.276504528504565 no 2471 0.278481915594781 3540 3533044
SGTC_1498 4478-3555 97.6 µM -0.588569729508822 0.276107494070333 no 2472 0.278074972486652 3501 3437919
SGTC_1959 st077091 55.8 µM -0.589361362026896 0.275848430172282 no 2473 0.277809444954517 3485 821356 YKL052C ASK1
SGTC_1071 trifluoperazine 6.31 µM -0.590604203631157 0.27544194795802 no 2474 0.277392823829368 3558 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1398 3558-0053 112 µM -0.590901567757718 0.275344736125116 no 2475 0.277293187746017 3404 4532369
SGTC_2747 doxorubicin 7.63 µM -0.591160141496272 0.275260219052759 no 2476 0.277206563163486 3420 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1464 k208-0027 110 µM -0.59126969259032 0.275224415177828 no 2477 0.277169866531471 3554 X1464
SGTC_1414 3917-0015 5.4 µM -0.591682183326158 0.275089624072833 no 2478 0.277031714698876 3501 6618702
SGTC_997 3996-0078 137 µM -0.592621426763152 0.274782825416186 no 2479 0.276717268101596 3469 735687
SGTC_3144 9087057 49.47 µM -0.593124894114554 0.274618440072536 no 2480 0.276548785745194 3476 17249618
SGTC_1508 1080-0625 72.9 µM -0.595762162253587 0.273758148340835 no 2481 0.275667062179017 3466 767111
SGTC_778 3456-2434 196 µM -0.596390356136501 0.273553424694761 no 2482 0.275457240745505 3510 5539063
SGTC_2205 7238770 200 µM -0.597994357430017 0.273031036747978 no 2483 0.274921849040876 3534 279867
SGTC_1436 4092-1007 8.32 µM -0.598261753631961 0.272943999800447 no 2484 0.274832646070395 3486 2881121
SGTC_1178 0988-0033 191 µM -0.600561020883953 0.272196160998195 no 2485 0.274066203259255 3532 5392207
SGTC_3042 9091578 49.47 µM -0.60305115624918 0.271387392527672 no 2486 0.273237329080072 3503 25236497
SGTC_603 3794-0023 45.9 µM -0.603083898308038 0.271376766249245 no 2487 0.27322643873416 3517 3802260
SGTC_2289 7946404 165.07 µM -0.604610056546527 0.27088168907308 no 2488 0.272719061529451 3531 1246120 YPR165W RHO1
SGTC_465 cgp-37157 41 µM -0.604703610829846 0.270851355256354 no 2489 0.272687974260981 3449 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1722 st034304 3.6505 µM -0.605129183705732 0.270713389926959 no 2490 0.272546582322074 3493 4036148 YLR033W RSC58
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.605903863284033 0.270462338738948 no 2491 0.272289296962526 3483 688664
SGTC_990 3985-0011 41.3 µM -0.607904766158167 0.269814442914323 no 2492 0.271625319150994 3463 5399565 YGL099W LSG1
SGTC_1068 loratadine 26.9 µM -0.608656358052406 0.269571277085346 no 2493 0.271376120016528 3503 3957 A H1 histamine antagonist.
SGTC_2883 9059145 45.46 µM -0.609882385194057 0.26917485094146 no 2494 0.270969860930726 3502 16476510
SGTC_3255 9139072 49.47 µM -0.61042923490878 0.268998125794306 no 2495 0.270788753494984 3545 17646060
SGTC_3322 9139058 2.11 µM -0.610943900784058 0.268831854699704 no 2496 0.270618360019876 3559 4908926 YPR165W RHO1
SGTC_1871 st057448 67.3 µM -0.612797904730061 0.268233317070501 no 2497 0.270004988236124 3635 691747
SGTC_1408 3909-7976 48.8 µM -0.614367875595827 0.267727000107262 no 2498 0.269486129447513 3536 24152374
SGTC_2244 6635614 200 µM -0.615591871861224 0.267332594627955 no 2499 0.269081958584276 3409 836499
SGTC_592 k241-0073 46.5 µM -0.615643944637909 0.26731582184091 no 2500 0.269064770591356 3556 4230158
SGTC_1539 benzyladenosine 56 µM -0.616859397168255 0.266924472076757 no 2501 0.268663735029197 3517 92208 A nucleotide analog.
SGTC_308 4092-1169 104 µM -0.617215250837026 0.266809949588342 no 2502 0.268546378854641 3519 2268590 YDL196W YDL196W
SGTC_2889 9059656 51.95 µM -0.617220238124932 0.266808344732518 no 2503 0.268544734291386 3562 3949838
SGTC_927 2425-1185 123 µM -0.617969887046926 0.26656717122552 no 2504 0.268297594381123 3513 730375
SGTC_2344 7990960 76.95 µM -0.619488005893993 0.266079107121332 no 2505 0.267797460462555 3505 140813
SGTC_887 0885-0007 9.62 µM -0.620345767126655 0.265803543388248 no 2506 0.267515084678345 3567 5719458
SGTC_2051 5263410 176 µM -0.621351553160041 0.26548060967051 no 2507 0.267184170338771 3610 227584
SGTC_446 go6976 132 µM -0.621470666355877 0.265442378473724 no 2508 0.267144994513696 3526 3501 A protein kinase C inhibitor.
SGTC_1220 1838-0075 193 µM -0.621668042359195 0.265379033785802 no 2509 0.267080084767138 3517 5529645
SGTC_1430 4049-0248 69.1 µM -0.622252687326006 0.265191446314612 no 2510 0.266887863166014 3592 22774488
SGTC_1849 st056239 19.2 µM -0.622484918840651 0.265116951880703 no 2511 0.266811528682402 3455 5393181
SGTC_1924 st058459 75.1 µM -0.622723218112947 0.265040522102506 no 2512 0.266733211197651 3528 688683
SGTC_294 k038-0071 157 µM -0.623104910411933 0.264918125175368 no 2513 0.266607791551809 3551 24152826
SGTC_3095 9117207 49.47 µM -0.623851209441907 0.264678893155575 no 2514 0.266362652557997 3523 17015229
SGTC_274 sirtinol 40.1 µM -0.62385835046387 0.264676604575659 no 2515 0.26636030747693 3543 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2147 5545932 89.7195 µM -0.624511614488241 0.264467286796832 no 2516 0.266145822567721 3547 797404
SGTC_1188 1403-0014 4.57 µM -0.625434319159977 0.264171778886319 no 2517 0.265843021799617 3567 9614867
SGTC_1143 3454-2408 5.08 µM -0.62688042962003 0.263708982201046 no 2518 0.265368808284098 3530 X1143
SGTC_1641 st009299 47.1 µM -0.6272686247218 0.263584819113931 no 2519 0.265241583142618 3528 4046054
SGTC_863 0466-0191 129 µM -0.62746668053795 0.263521483024225 no 2520 0.265176685242291 3556 765160 YPR165W RHO1
SGTC_2118 5526350 200 µM -0.628839669380673 0.263082629818911 no 2521 0.264727013213035 3543 743594
SGTC_696 1560-0013 611 µM -0.635125732392905 0.261078173858337 no 2522 0.262673207795931 3634 1650269
SGTC_2377 9073351 62.6 µM -0.636310670888713 0.26070121026535 no 2523 0.262286975587075 3529 7337946 YHR072W ERG7
SGTC_2592 piperlongumine 83.33 µM -0.636553880116114 0.260623872956876 no 2524 0.26220773722623 3524 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1280 0880-0253 10.1 µM -0.636978845320734 0.26048876800902 no 2525 0.262069311618078 3536 6836607
SGTC_787 4152-0075 138 µM -0.637121791958186 0.260443330518042 no 2526 0.262022757460779 3549 9566539
SGTC_3230 9131665 49.47 µM -0.637442446841138 0.260341420946257 no 2527 0.261918343579592 3509 15943720
SGTC_3167 9103034 49.47 µM -0.637577183678435 0.260298605419729 no 2528 0.261874475997134 3572 5127859
SGTC_2628 lathosterol 100 µM -0.638258447218045 0.260082174845771 no 2529 0.261652728107089 3628 6710616
SGTC_1124 fisetin 1.16336 µM -0.638625983689185 0.259965450745772 no 2530 0.261533136844072 3531 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2834 9001755 58.44 µM -0.639240478582788 0.259770356698966 no 2531 0.261333251436602 3482 2989575
SGTC_467 ro 31-8220 72.8 µM -0.63969685683995 0.25962551151284 no 2532 0.26118484965291 3526 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.640127510666349 0.259488868983785 no 2533 0.261044852478287 3563 2374 Ca(2+)-ATPase inhibitor.
SGTC_3094 9117742 49.47 µM -0.640382700471463 0.259407917116023 no 2534 0.260961913447656 3542 17149698
SGTC_1717 st033143 58.0435 µM -0.640960029565297 0.259224823673609 no 2535 0.260774326207729 3611 674616
SGTC_751 0833-0568 350 µM -0.64427503192856 0.258174802207696 no 2536 0.259698551684236 3597 6954252
SGTC_2390 9097792 176.6 µM -0.644484542606524 0.258108514211472 no 2537 0.259630638952953 3517 4497149
SGTC_1995 st072814 61.1 µM -0.64541314197397 0.257814816891102 no 2538 0.259329744564089 3529 5769371
SGTC_1709 st033179 39.1045 µM -0.645460213673418 0.257799933678514 no 2539 0.259314496703962 3576 573381
SGTC_2871 9038510 12.99 µM -0.648659908531812 0.256789294872346 no 2540 0.258279111737344 3617 4945164
SGTC_1558 st069300 45.6 µM -0.64979898928659 0.256430009212448 no 2541 0.257911035951225 3550 24208000
SGTC_522 1273-0010 11.6 µM -0.65194695040347 0.255753218674379 no 2542 0.257217697754845 3655 5705015
SGTC_1 0258-0098 57.368 µM -0.652009090106035 0.255733653268746 no 2543 0.257197654174611 3520 6790032 YDR047W HEM12
SGTC_3313 9133968 57.047 µM -0.654578306733542 0.254925390245541 no 2544 0.25636964743153 3590 1494643
SGTC_2324 6149169 200 µM -0.658122633757092 0.253812560328067 no 2545 0.255229666537416 3535 2888231
SGTC_27 0485-0001 32.618 µM -0.658149794680228 0.253804042335667 no 2546 0.255220940868607 3548 2054479
SGTC_1274 0865-0114 173 µM -0.65827725434019 0.253764071456902 no 2547 0.255179995493392 3604 870624
SGTC_1078 idebenone 36.1 µM -0.658925801612756 0.253560740631406 no 2548 0.254971708195426 3612 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2210 7115885 190.385 µM -0.659175806614022 0.253482382586822 no 2549 0.254891440406456 3614 2927039
SGTC_1502 4534-4282 27.7 µM -0.661242214382043 0.25283520439644 no 2550 0.254228496488282 3593 3278949
SGTC_2172 5754775 163.918 µM -0.661632151196542 0.252713177726925 no 2551 0.254103498630209 3542 2263357
SGTC_1564 D-Arginine 115 µM -0.662047473156193 0.252583241156678 no 2552 0.253970398790635 3575 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1205 4161-2785 76 µM -0.663240334706479 0.252210241327097 no 2553 0.253588321344945 3583 3498106
SGTC_1531 st059297 52.4 µM -0.663447926525676 0.252145358440862 no 2554 0.253521859867589 3630 7566702
SGTC_2937 9044753 11.33 µM -0.66354335306229 0.252115535801793 no 2555 0.253491311692888 3633 6465530 YGL099W LSG1
SGTC_1578 josamycin 24.2 µM -0.664847116164092 0.251708271043784 no 2556 0.253074141686474 3556 5282165 A P450 substrate.
SGTC_2269 7935389 174.42 µM -0.668625179111908 0.250530058484756 no 2557 0.251867303317504 3600 97605
SGTC_1270 0831-1170 17.3 µM -0.668892442063015 0.250446821671436 no 2558 0.251782045884659 3616 6764716
SGTC_981 1488-1094 54.9 µM -0.670114167584879 0.250066512170239 no 2559 0.251392507037799 3609 3449522
SGTC_3286 9117135 37.221 µM -0.670534312532163 0.249935796579015 no 2560 0.251258620335957 3589 3438150
SGTC_912 3474-0017 2.18 µM -0.672161436244961 0.249429907839965 no 2561 0.250740464227946 3660 3360550
SGTC_3129 9127257 49.47 µM -0.672178702761809 0.249424542429995 no 2562 0.250734968756666 3543 837894
SGTC_1914 st062367 72.6 µM -0.672634049219619 0.249283069882977 no 2563 0.250590067159797 3625 978205
SGTC_2416 tofa 880 nM -0.674100716911454 0.248827677999862 no 2564 0.250123641881772 3570 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2596 sinensetin 100 µM -0.674889560932161 0.248582929752192 no 2565 0.249872966647151 3619 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1942 st076330 65.2 µM -0.675745823823163 0.248317409222084 no 2566 0.24960101836692 3673 24208414
SGTC_2400 5203494 178.7 µM -0.677579214774322 0.247749397642971 no 2567 0.249019264285268 3615 6777674
SGTC_3241 9133421 49.47 µM -0.677701073519172 0.247711668608902 no 2568 0.248980622820032 3652 17018221
SGTC_1561 5-methoxyflavone 52.9 µM -0.678390039024445 0.247498413755681 no 2569 0.248762211565832 3609 94525
SGTC_1035 k081-0041 55.2 µM -0.679027633108715 0.24730114728269 no 2570 0.248560176663783 3673 731709
SGTC_3060 1327-0027 12.5 µM -0.679107557425298 0.247276425273209 no 2571 0.24853485715463 3567 16000455 YPR107C YTH1
SGTC_919 tnp00227 403.569 nM -0.68142940031941 0.246558815167011 no 2572 0.247799912464625 3655 1269246 A methoxyflavone. YNL221C POP1
SGTC_2674 ligustilide 100 µM -0.682408490391002 0.246256543341734 no 2573 0.247490344283164 3621 5319022 A signalling regulator.
SGTC_3079 9117512 49.47 µM -0.683363675949135 0.245961843065822 no 2574 0.247188533471831 3665 7185044
SGTC_1356 1502-0781 85.8 µM -0.683668235958977 0.245867917966452 no 2575 0.247092342781575 3627 567702
SGTC_1825 st052143 62.6 µM -0.683989196837157 0.245768955741549 no 2576 0.246990993797522 3663 674173
SGTC_2659 sanguinarine 24.21 µM -0.687706139939127 0.244624465938843 no 2577 0.245818926355966 3608 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_876 0720-0963 56.8 µM -0.688485888035543 0.244384737214035 no 2578 0.245573427004527 3670 765861
SGTC_233 rapamycin 362 pM -0.690727042966948 0.243696413452232 no 2579 0.24486854570106 3670 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_85 0868-0259 160.055 µM -0.691238283369594 0.243539543424443 no 2580 0.244707904570303 3617 83173
SGTC_392 N-ethylmaleimide 8.33 µM -0.691549407605141 0.243444104144218 no 2581 0.244610171397038 3632 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2398 5228213 48.84 µM -0.692691096435976 0.243094057234686 no 2582 0.244251713900952 3671 80771 YMR134W ERG29
SGTC_1321 1326-2144 215 µM -0.693059312684931 0.24298121856055 no 2583 0.244136164998533 3653 3513030
SGTC_2388 9080168 200 µM -0.69558330896795 0.242208511390517 no 2584 0.243344910990421 3635 15943073
SGTC_747 3448-8087 38.7 µM -0.69712144082428 0.241738275039821 no 2585 0.242863398592361 3688 5168703
SGTC_901 1112-0062 60.1 µM -0.698131619303981 0.241429713922724 no 2586 0.242547442781727 3674 1908457
SGTC_53 0973-0023 39.979 µM -0.698178752979674 0.241415322069386 no 2587 0.242532706112938 3639 674768
SGTC_1038 k292-0204 154 µM -0.698982552190835 0.241169960806015 no 2588 0.24228146741135 3631 4454212
SGTC_1382 3002-2117 298 µM -0.69954534883443 0.240998246757374 no 2589 0.242105641426187 3709 1497314
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.700153775380809 0.240812685455841 no 2590 0.241915637839997 3608 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1899 st063254 59.6 µM -0.701481613928987 0.240407983995684 no 2591 0.241501252440968 3617 3093813
SGTC_1138 3761-0006 1.03 µM -0.703091240060762 0.23991789585189 no 2592 0.240999445475883 3646 12061087
SGTC_616 4092-0450 108 µM -0.706073376893434 0.23901135659468 no 2593 0.240071253533399 3718 787165
SGTC_2650 prasterone 100 µM -0.706587577059505 0.238855234484272 no 2594 0.239911405638256 3641 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1261 0712-0010 12.7 µM -0.707321086575967 0.238632621954838 no 2595 0.239683482191328 3690 2840123
SGTC_1494 4358-1428 177 µM -0.707628691041779 0.238539300992759 no 2596 0.239587935421746 3710 1564571
SGTC_2918 7977171 22.06 µM -0.708981645214121 0.238129079374563 no 2597 0.239167933587028 3640 2236483
SGTC_2002 4023503 131 µM -0.710342044388719 0.237716990487303 no 2598 0.238746026588154 3734 4736863 YCR052W RSC6
SGTC_469 w7 172 µM -0.711491691737947 0.237369047263245 no 2599 0.238389798734526 3731 45115570 A P450 inhibitor.
SGTC_1386 3228-0095 33.8 µM -0.711559388279265 0.237348567482167 no 2600 0.238368831472715 3672 870181
SGTC_772 k072-0172 35.3 µM -0.712037719780898 0.237203888709827 no 2601 0.238220709380436 3688 5861980
SGTC_1859 st055998 20 µM -0.713117556356931 0.23687745361209 no 2602 0.237886508253592 3690 676301
SGTC_2443 5493264 126.67 µM -0.71463466925771 0.236419247238064 no 2603 0.237417408111684 3720 5340055
SGTC_347 4534-1311 26.2 µM -0.71627235019289 0.235925174355067 no 2604 0.236911598161542 3705 2862016
SGTC_3021 9087658 49.47 µM -0.716320693736681 0.235910598216831 no 2605 0.236896675905459 3675 25237042
SGTC_100 0086-0128 49.5915 µM -0.716333039631466 0.235906875866166 no 2606 0.23689286516705 3678 93297
SGTC_3340 9146634 11.102 µM -0.720887641315951 0.234535851251452 no 2607 0.235489323619509 3715 4907387
SGTC_358 0075-0058 9.45 µM -0.72095393331421 0.234515928653634 no 2608 0.235468929078327 3691 1069125
SGTC_834 0312-0008 75.7 µM -0.723784611382428 0.233666104801672 no 2609 0.234598989128268 3713 6385573 YIL048W NEO1
SGTC_1707 st032323 6.317 µM -0.723836515899681 0.23365053802652 no 2610 0.234583054152539 3639 3132057 YMR211W DML1
SGTC_2846 9008642 19.48 µM -0.724340092059422 0.233499539467521 no 2611 0.234428484551483 3728 2992898
SGTC_3218 9131285 49.47 µM -0.72802000453898 0.232397753068912 no 2612 0.233300670334793 3717 17156417
SGTC_418 lividomycin a 100 µM -0.730167188424496 0.23175621247492 no 2613 0.232643998053997 3722 72394 An antibiotic.
SGTC_897 1000-0139 31.4 µM -0.730930585023686 0.231528361049323 no 2614 0.232410776633936 3686 6151020
SGTC_3199 9111318 49.47 µM -0.732689133223213 0.231003961623192 no 2615 0.23187402663596 3688 8548020
SGTC_1446 4239-0190 62 µM -0.732877980577761 0.230947686753827 no 2616 0.231816427092807 3742 1340085
SGTC_1763 st044482 94.5 µM -0.732880191553618 0.230947027947581 no 2617 0.231815752779499 3759 88505
SGTC_917 harmaline 728.087 nM -0.733708087698828 0.230700412835465 no 2618 0.231563334128129 3746 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2938 9059746 27.26 µM -0.734064046096656 0.23059442458452 no 2619 0.231454852487404 3716 6471769
SGTC_2122 5258151 111.688 µM -0.734309238216351 0.230521433331872 no 2620 0.231380144387542 3735 2173356
SGTC_924 2046-0044 21.3 µM -0.735792787256691 0.230080071095247 no 2621 0.230928405683013 3732 3623589
SGTC_2121 5257820 149.641 µM -0.736405121791851 0.229898036878481 no 2622 0.230742094298645 3795 791256
SGTC_686 1319-0111 510 µM -0.737656486765018 0.229526283160775 no 2623 0.230361610176762 3761 4562600
SGTC_214 4373-3496 70 µM -0.738026635101715 0.229416384608299 no 2624 0.230249131887919 3806 3779166
SGTC_1040 k898-0338 155 µM -0.738467713605373 0.229285465119181 no 2625 0.230115139915569 3737 20969351
SGTC_710 3448-4187 58 µM -0.741133003658692 0.228495254287348 no 2626 0.22930640012972 3755 3946412
SGTC_1496 4469-0713 57.4 µM -0.742974640166488 0.227950137013907 no 2627 0.228748517093606 3707 746691
SGTC_3203 9113543 49.47 µM -0.743537310715962 0.227783734733099 no 2628 0.228578220595296 3812 17018012
SGTC_1880 MG-132 525 µM -0.746474893161479 0.226916095061921 no 2629 0.227690296300758 3683 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1130 3454-2858 15.9 µM -0.747067100778599 0.226741407606384 no 2630 0.227511528944042 3791 715628 YIL048W NEO1
SGTC_2177 5811945 192 µM -0.747160898454591 0.226713746439234 no 2631 0.22748322186597 3774 5343475
SGTC_1619 st003326 88.7 µM -0.747829230275828 0.226516708860356 no 2632 0.227281584309363 3708 2849032
SGTC_3301 9125354 19.7965 µM -0.750192230615782 0.225820824906899 no 2633 0.226569468715936 3733 41905162
SGTC_2695 st077686 51.995 µM -0.750210729872345 0.225815381803781 no 2634 0.226563898739175 3800 2876092
SGTC_1024 4507-0395 26 µM -0.751280405997875 0.225500773349853 no 2635 0.226241959384811 3800 4201836
SGTC_903 1134-0042 114 µM -0.752065233193696 0.225270101294207 no 2636 0.226005915202046 3755 701009
SGTC_445 e6 berbamine 66 µM -0.753391370659296 0.224880634171386 no 2637 0.225607383391192 3841 6610268 A calcium/calmodulin antagonist.
SGTC_1127 asiatic acid 681.4 nM -0.753791249284018 0.224763270631984 no 2638 0.225487289652266 3742 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1863 st057641 20.1 µM -0.75475658743997 0.224480089083488 no 2639 0.225197523177624 3775 3921635
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.75515538997958 0.2243631596469 no 2640 0.225077875835817 3753 688662
SGTC_2677 mitomycin C 100 µM -0.758018365852589 0.223524746967311 no 2641 0.224219994019534 3769 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1394 3474-0001 65.7 µM -0.75805215405257 0.223514862860332 no 2642 0.224209880588279 3753 5017666 YIL048W NEO1
SGTC_2091 4-phenylthiadiazole 200 µM -0.760224707059445 0.222879845179669 no 2643 0.223560139432983 3773 270010
SGTC_983 1491-0821 12.2 µM -0.761382316449027 0.222541906552628 no 2644 0.223214373262736 3760 46495113
SGTC_757 1066-0008 322 µM -0.762861137919644 0.222110622427215 no 2645 0.222773107464497 3823 6842497
SGTC_2259 7964009 200 µM -0.763135477915746 0.222030666287646 no 2646 0.222691301802778 3791 313134
SGTC_2013 4024628 200 µM -0.763813945739792 0.221832998050626 no 2647 0.222489062493224 3791 5230760
SGTC_2757 clomiphene 4.22 µM -0.76427993928718 0.221697291388072 no 2648 0.222350218717547 3827 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_399 oxolinic acid 75 µM -0.766439013085749 0.221069145192278 no 2649 0.22170756345959 3753 4628 A DNA gyrase inhibitor.
SGTC_2612 dictamnine 15.46 µM -0.766764733658988 0.220974470764115 no 2650 0.221610703896584 3764 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_949 1165-0505 146 µM -0.768926065138691 0.22034684313201 no 2651 0.220968601463035 3822 6244267
SGTC_2253 7938677 135.83 µM -0.768947042917676 0.220340756420213 no 2652 0.220962374470428 3821 2301972
SGTC_1229 0139-0193 12.2 µM -0.769172488780055 0.220275349288458 no 2653 0.220895460012508 3796 3090752
SGTC_1583 clindamycin 39.6 µM -0.771223261326547 0.219680883514375 no 2654 0.220287304354761 3762 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2381 9035592 200 µM -0.7743700881025 0.218770493686448 no 2655 0.219355983547222 3821 4749657
SGTC_2512 diallyl trisulfide 49.23 µM -0.7748694357659 0.218626230225875 no 2656 0.219208407126493 3815 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2585 alliin 100 µM -0.775242038273755 0.218518619614957 no 2657 0.219098325961688 3824 87310 A garlic compound which reacts with lipids.
SGTC_1930 st074634 34.3 µM -0.776038422204465 0.2182887197968 no 2658 0.21886315000932 3726 684253 YOR116C RPO31
SGTC_1388 3346-4487 254 µM -0.776424661474449 0.218177270587504 no 2659 0.218749144040066 3850 3345614
SGTC_1009 4106-0057 9.87 µM -0.777393073133446 0.217897979960478 no 2660 0.218463448979075 3780 2928005
SGTC_3183 9108214 49.47 µM -0.779748722936832 0.217219470235867 no 2661 0.217769396936151 3743 4974831
SGTC_2242 6630449 61.2675 µM -0.779995406537883 0.217148487371609 no 2662 0.21769678946716 3875 691249 YDR170C SEC7
SGTC_3005 9076496 71.4286 µM -0.780589579835961 0.216977569850677 no 2663 0.217521961176152 3808 21368410
SGTC_2781 5567276 71.43 µM -0.780866046123808 0.216898069174138 no 2664 0.217440641956273 3843 2853274
SGTC_3285 9112818 20.8695 µM -0.781423327750492 0.216737868397954 no 2665 0.217276777651342 3807 17017947 YPR165W RHO1
SGTC_407 eburnamonine 100 µM -0.781675754901249 0.216665326128389 no 2666 0.217202576896869 3688 3195
SGTC_2497 7-hydroxyflavone 100 µM -0.782048715485457 0.216558170784681 no 2667 0.217092972232817 3778 5281894
SGTC_1480 1070-0044 41.2 µM -0.782278550215617 0.216492152216351 no 2668 0.217025444931655 3801 3124987
SGTC_2949 9072542 2.23 µM -0.782581427802559 0.216405170338499 no 2669 0.216936475589355 3879 16457352
SGTC_306 1672-3436 11.6 µM -0.783392247573847 0.216172414695309 no 2670 0.216698403610194 3811 6797378
SGTC_2636 apigenin dimethyl ether 100 µM -0.783853284870743 0.216040133026334 no 2671 0.216563101776545 3805 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3076 9116187 49.47 µM -0.784985970879162 0.215715339857152 no 2672 0.216230897038519 3796 27241210
SGTC_1690 st023502 41.2 µM -0.785120894303408 0.215676669983011 no 2673 0.216191345111755 3770 24207482
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.785246881788195 0.21564056483229 no 2674 0.216154416480223 3796 4330530
SGTC_1278 0874-0585 172 µM -0.786388078185489 0.215313683549132 no 2675 0.215820082861633 3870 766306
SGTC_2987 9018338 71.43 µM -0.788608625031827 0.214678460686449 no 2676 0.215170394156123 3866 5055682
SGTC_3332 9141069 11.198 µM -0.788962079136944 0.214577450069853 no 2677 0.215067085213071 3760 17332883
SGTC_2085 5307070 144.047 µM -0.792937617782483 0.213443219361482 no 2678 0.213907084481146 3777 2840351
SGTC_1603 st002045 67.8 µM -0.793229332015687 0.213360130433819 no 2679 0.213822110471907 3816 5887985
SGTC_2372 9071633 200 µM -0.793241521372915 0.213356658951227 no 2680 0.213818560238115 3878 21321366
SGTC_3174 9107204 49.47 µM -0.793883531802932 0.213173863367002 no 2681 0.21363161882511 3848 3938802
SGTC_1523 st012844 44.7 µM -0.794160128168607 0.213095137988452 no 2682 0.21355110850211 3946 4274103
SGTC_1588 farnesol 29.9 µM -0.794390764171894 0.213029506903387 no 2683 0.213483989617232 3821 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2951 9072950 58.06 µM -0.795083920035403 0.212832329549181 no 2684 0.213282343831309 3827 16488155
SGTC_1993 st073995 70.8 µM -0.795698875421435 0.212657486567582 no 2685 0.213103540329903 3817 3098394
SGTC_2972 9093619 59.92 µM -0.797099587592843 0.212259551907619 no 2686 0.212696597931139 3832 25236256
SGTC_3239 9133757 49.47 µM -0.798798955462433 0.21177735560521 no 2687 0.21220349816321 3831 17036923
SGTC_2664 lyso-paf C-16 73.48 µM -0.800792702725954 0.211212447009646 no 2688 0.21162583212276 3815 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2385 9074692 200 µM -0.801654036391468 0.210968669995934 no 2689 0.211376555310788 3851 17046906
SGTC_166 k072-0058 166.424 µM -0.801704786936093 0.210954311585598 no 2690 0.211361873066728 3809 5846229
SGTC_2805 7950783 58.44 µM -0.80253170351123 0.210720440001445 no 2691 0.21112272845704 3872 1178958 YDL195W SEC31
SGTC_131 0141-0277 33.849 µM -0.803181309589586 0.21053682274301 no 2692 0.210934973381953 3788 1547771
SGTC_2409 alverine citrate 63.97 µM -0.804062274049807 0.210287959941582 no 2693 0.210680505469311 4029 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1085 doxorubicin 7.67 µM -0.804285015325228 0.210225065342597 no 2694 0.210616194852027 3833 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2396 5342950 42.78 µM -0.805052734087502 0.210008372219142 no 2695 0.210394624771452 3849 1886677
SGTC_1998 st075797 76.8 µM -0.805266378047177 0.209948093310197 no 2696 0.210332989678421 3790 24208315
SGTC_3344 9148862 3.898 µM -0.805825753024219 0.209790315754076 no 2697 0.210171663337073 3854 4905352
SGTC_2791 5663188 71.43 µM -0.805899589949106 0.209769494487196 no 2698 0.210150373856354 3833 54690634
SGTC_164 4100-3994 89.624 µM -0.806393553854448 0.209630232910172 no 2699 0.210007981294427 3813 4615967
SGTC_1087 pterostilbene 9.05 µM -0.807317669871113 0.209369846060368 no 2700 0.209741743176613 3896 5281727 Similar to reservatol, lowers cholesterol.
SGTC_704 1310-0270 142 µM -0.80735298381126 0.20935989947896 no 2701 0.209731573157466 3833 5718033
SGTC_605 1315-0399 119 µM -0.808654936254863 0.208993383604252 no 2702 0.209356827878524 3931 24020461
SGTC_775 4577-0580 57.3 µM -0.80906136991931 0.208879044899558 no 2703 0.209239923486672 3928 2006902
SGTC_32 0928-0142 34.1 µM -0.813289874700445 0.207691661631051 no 2704 0.208025940451977 3800 2244242
SGTC_2341 7987486 176.74 µM -0.8133499705375 0.207674815237453 no 2705 0.208008717250625 3870 1258686
SGTC_524 r073-0010 27.8 µM -0.814463330638981 0.207362858093281 no 2706 0.207689785455454 3788 2772106
SGTC_1192 1488-0095 21.4 µM -0.815790176023006 0.206991445652004 no 2707 0.207310076465927 3900 915875
SGTC_1954 st077032 68.9 µM -0.818920480776007 0.206116767655541 no 2708 0.206415891984623 3796 698907
SGTC_2549 cedrol 20.94 µM -0.819558206673507 0.205938841695145 no 2709 0.206234003555308 3785 6708665 A sedative which affects the nervous system.
SGTC_550 4123-0385 25.7 µM -0.81988495491695 0.205847714021222 no 2710 0.206140847164075 3874 5731123
SGTC_512 prima-1 270 µM -0.820160329526872 0.205770932655152 no 2711 0.206062356845457 3873 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_431 k089-0097 107 µM -0.821007011971393 0.205534962777873 no 2712 0.205821137085961 3770 5499420
SGTC_2685 mycophenolic acid 18.85 µM -0.821352588519645 0.205438696994048 no 2713 0.20572273052192 3844 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2371 9071574 200 µM -0.82177263218762 0.205321723281399 no 2714 0.205603156264393 3848 45596039
SGTC_1951 sophoraflavanone G 9.2 µM -0.823504850447072 0.204839753496456 no 2715 0.205110480009742 3859 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_396 dithiazanine 1.25 µM -0.823633022267305 0.204804117915889 no 2716 0.205074053373225 3858 10578 An antihelmenthic.
SGTC_2772 vinpocetine 57.06 µM -0.824504177571591 0.204562008521038 no 2717 0.204826571535932 3859 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2125 5246583 200 µM -0.825635027510423 0.204247979575087 no 2718 0.204505579500045 3840 835267
SGTC_405 ebelactone b 50 µM -0.826363231011956 0.204045914697237 no 2719 0.204299037305552 3842 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_873 0591-4978 488 µM -0.827232408860583 0.203804887655831 no 2720 0.20405267286567 3926 3305145
SGTC_2649 anisomycin 9.56 µM -0.827364002458241 0.203768410939729 no 2721 0.204015388701862 3862 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_964 1287-0107 19.4 µM -0.828898616158559 0.203343315426449 no 2722 0.20358088925548 3895 51516812 YPR165W RHO1
SGTC_2195 6536160 144.242 µM -0.829097355636969 0.20328830234602 no 2723 0.203524659984948 3796 3834386
SGTC_1570 verbenone 133 µM -0.83001506735786 0.203034385765267 no 2724 0.203265132395776 3899 29025 A natural terpanoid with antifungal properties.
SGTC_3133 9127736 49.47 µM -0.830207781551736 0.202981088810742 no 2725 0.203210658195051 3830 27243420
SGTC_3087 9117406 49.47 µM -0.83308313347753 0.202186875465694 no 2726 0.202398922627193 3868 42546093
SGTC_934 2950-0684 338 µM -0.833544828967271 0.20205952201933 no 2727 0.202268763087154 3943 1121253
SGTC_1023 4482-3888 16 µM -0.833828579613172 0.201981276456618 no 2728 0.202188793967934 3878 3303168
SGTC_2476 5806916 10.51 µM -0.837127339977168 0.201072959599452 no 2729 0.201260497038349 3784 2870194
SGTC_1350 1495-0454 146 µM -0.837310690435601 0.201022545847974 no 2730 0.201208975856482 3906 1069057
SGTC_2421 5690543 90.72 µM -0.838304155830333 0.200749516046382 no 2731 0.200929951229935 3933 3397993
SGTC_2588 indole-3-carbinol 100 µM -0.838593088629522 0.200670151693507 no 2732 0.200848845180388 3935 3712 Induces cell cycle arrest.
SGTC_857 0438-0306 1.35 µM -0.838643990928612 0.200656171750385 no 2733 0.200834558480447 3963 4686136
SGTC_3288 9119690 36.221 µM -0.839217344625589 0.200498744750552 no 2734 0.200673677968349 3890 17595618 YKL019W RAM2
SGTC_1073 triclabendazole 3.09 µM -0.839848838186715 0.200325440026731 no 2735 0.200496573229639 3964 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1317 1273-0028 910 nM -0.840698241288252 0.200092475020156 no 2736 0.200258503046703 3881 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_103 0844-0104 51.839 µM -0.841149685445084 0.199968724153597 no 2737 0.200132041714168 3872 5375804
SGTC_2673 kobusone 100 µM -0.842822356769888 0.199510609099039 no 2738 0.19966390123216 3928 6710676 An epoxy ketone and protein crosslinker.
SGTC_1554 st069299 38.7 µM -0.843944043289886 0.199203753172964 no 2739 0.199350337543293 3847 24207999
SGTC_155 k072-0202 43.6 µM -0.846740973714083 0.198439845655214 no 2740 0.198569757558852 3808 5857737
SGTC_805 3852-0218 479 µM -0.84823468478361 0.198032603027196 no 2741 0.198153642176454 3838 6615355
SGTC_3307 9126885 69.2785 µM -0.848917693612711 0.197846557037077 no 2742 0.197963546316055 3881 24824909
SGTC_1160 4092-0570 10.5 µM -0.849630053456443 0.197652628614323 no 2743 0.197765398839009 3888 4994975
SGTC_1170 0310-0127 64.8 µM -0.849900619141948 0.197579001607402 no 2744 0.19769017066604 3912 774975
SGTC_3272 9137413 49.47 µM -0.852308340000991 0.19692453712963 no 2745 0.197021489168064 3846 17614870
SGTC_426 0988-0037 14.6 µM -0.85441585900895 0.196352751773937 no 2746 0.196437305934864 3892 5383008
SGTC_1813 st051246 8.6015 µM -0.856053367941793 0.195909179095247 no 2747 0.195984130312626 3834 5291959
SGTC_1260 0700-1617 7.75 µM -0.864540697316905 0.193619867073946 no 2748 0.193645466878521 3946 2853078
SGTC_788 1182-0090 188 µM -0.865583419377987 0.193339740251398 no 2749 0.193359325730902 4005 5715185
SGTC_1049 3226-0134 66 µM -0.866031212002537 0.193219516905679 no 2750 0.193236522841549 3951 5702385
SGTC_2214 7179297 48.276 µM -0.867597237260854 0.192799429457669 no 2751 0.192807429704951 3942 769744
SGTC_2079 5212404 121 µM -0.868597970039804 0.192531274582917 no 2752 0.192533532595925 3872 758462
SGTC_52 0329-0193 875 nM -0.868790427268472 0.192479730179936 no 2753 0.192480884998671 4044 3739292
SGTC_340 k038-0059 454 µM -0.869077605372014 0.192402833070331 no 2754 0.192402342418781 3917 23733424
SGTC_1262 0737-0114 49.6 µM -0.871086728711393 0.191865379694274 no 2755 0.191853399922383 3987 765919
SGTC_2623 humulene 100 µM -0.872342848725947 0.191529826941759 no 2756 0.191510684301368 3930 6187145 An anti-inflammatory.
SGTC_1212 0520-0165 585 µM -0.873128628043615 0.191320101237923 no 2757 0.191296485703345 4056 5403258
SGTC_1771 st048882 4.1505 µM -0.87403217161645 0.191079118127124 no 2758 0.191050366881035 3950 4580403
SGTC_1088 bifonazole 369 nM -0.874746994801317 0.190888600366642 no 2759 0.19085579180018 3880 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1626 st003712 1.76 µM -0.874908920203657 0.190845459504147 no 2760 0.190811732553717 3945 24207035
SGTC_2003 4023581 200 µM -0.875599436405873 0.190661556361184 no 2761 0.190623915952572 3977 16641307
SGTC_920 mycophenolic acid 780.421 nM -0.876285597303138 0.190478920938351 no 2762 0.190437396421069 3963 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1102 cgs 12066b 26.1 µM -0.876674458070949 0.190375465587329 no 2763 0.190331741935287 3949 6438352 A 5-HT1B full agonist.
SGTC_894 0960-0238 55.9 µM -0.876699509148562 0.190368801999602 no 2764 0.190324936726764 3881 6741907 YDL195W SEC31
SGTC_1294 1000-1494 117 µM -0.877957069327362 0.190034475054314 no 2765 0.189983508411771 3934 712797 YDL207W GLE1
SGTC_3221 9128209 49.47 µM -0.878753291750624 0.189822983124649 no 2766 0.189767528344517 3981 16460723
SGTC_1333 1482-0047 286 µM -0.87949739360686 0.189625466302508 no 2767 0.189565822845792 3924 3811116
SGTC_1672 st016598 6.51 µM -0.882852050167644 0.188736566159537 no 2768 0.188658106809329 3988 4665860 YNL267W PIK1
SGTC_2179 6298986 200 µM -0.883270317552793 0.188625916109622 no 2769 0.188545118557931 3901 738374
SGTC_1140 3229-1848 2.98 µM -0.884190354392229 0.188382666826623 no 2770 0.188296732177886 3978 2849525
SGTC_39 0986-0283 58.349 µM -0.886639293600668 0.187736133366924 no 2771 0.187636565766856 4050 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1620 st003704 16.5 µM -0.887570569425501 0.187490631545454 no 2772 0.187385895253747 3872 2834414
SGTC_3242 9133940 49.47 µM -0.888254257758665 0.187310524800565 no 2773 0.187201999434763 3970 17248444
SGTC_301 4119-0100 24.5 µM -0.888348949179052 0.187285588298034 no 2774 0.187176538507939 3978 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1310 1188-0297 994 nM -0.888702429123952 0.18719251929132 no 2775 0.187081512628816 3843 1588352
SGTC_1344 1488-0097 29.1 µM -0.889212574337047 0.18705825175688 no 2776 0.186944423106316 3984 747966
SGTC_2014 4013930 200 µM -0.89080537654895 0.186639418113923 no 2777 0.186516795132269 3896 64556
SGTC_2873 9040596 71.43 µM -0.890875018127497 0.186621118843357 no 2778 0.186498111924876 3959 6463863
SGTC_620 0109-0052 432 µM -0.893742605544727 0.185868586169957 no 2779 0.185729811969961 3954 493037
SGTC_1286 0929-0070 131 µM -0.893926011910448 0.185820519484214 no 2780 0.185680739614574 4059 1420408
SGTC_224 benfluorex 43.875 µM -0.894493156666548 0.185671932379279 no 2781 0.185529044808641 3961 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_285 1486-1325 46 µM -0.895600352292399 0.185382069036639 no 2782 0.185233123744222 4002 22310230
SGTC_444 curcumin 90.4 µM -0.896233318674525 0.185216484987243 no 2783 0.18506408206834 3921 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_75 0159-0059 199.013 µM -0.896612202358889 0.185117412948522 no 2784 0.184962942256081 4015 5377270
SGTC_14 0354-0009 295 µM -0.896705765090447 0.185092952855891 no 2785 0.184937971760847 4027 1713507
SGTC_1681 tripelennamine 100 µM -0.897806427141548 0.184805357668738 no 2786 0.184644378792018 3934 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2514 salinomycin 42.74 µM -0.898149824431026 0.184715687270373 no 2787 0.184552839604097 4045 23682228 A polyether potassium ionophore.
SGTC_685 1278-0033 54.9 µM -0.89856208551048 0.184608070394971 no 2788 0.1844429807287 3990 3590572
SGTC_1718 roemerine 11.9335 µM -0.900232360258848 0.184172459980248 no 2789 0.183998304174152 3770 235224 An aporphine alkaloid with mutagenic activity.
SGTC_260 nsc-65238 3.989 µM -0.901113231480843 0.183942985196527 no 2790 0.183764059271451 3956 3246252
SGTC_3155 9099265 49.47 µM -0.901724286616311 0.183783904543332 no 2791 0.183601674156394 4003 25236499
SGTC_2770 toltrazuril 17.5 µM -0.902537373355824 0.183572360392282 no 2792 0.183385738767167 3886 68591 Kills coccidiodes.
SGTC_1609 st001574 46.4 µM -0.905492813061912 0.182804710367997 no 2793 0.182602182812623 3962 3960012
SGTC_2999 9069765 71.4286 µM -0.906949460371324 0.182427097049173 no 2794 0.182216761988399 3982 2097066
SGTC_2025 5147754 141 µM -0.90802356684296 0.182148963909654 no 2795 0.181932885291544 3966 315777 YLR208W SEC13
SGTC_1703 st026983 48.3 µM -0.913202822836406 0.180811551707216 no 2796 0.180567939798575 3994 1104023
SGTC_2297 7971671 152.32 µM -0.914269578256635 0.18053685543114 no 2797 0.180287605857284 4007 909016
SGTC_1893 st059353 36.1 µM -0.915061517727666 0.180333095386368 no 2798 0.180079667870745 4000 3112488
SGTC_3147 9097027 49.47 µM -0.9177057569137 0.179653798450858 no 2799 0.179386466458362 4001 25236841
SGTC_994 3910-0338 138 µM -0.91799882488878 0.17957860929279 no 2800 0.179309740535298 4083 3479481
SGTC_623 k072-0108 16.9 µM -0.918095739523358 0.179553749345748 no 2801 0.179284372584551 3961 5382803
SGTC_1752 st044819 83.042 µM -0.918539105258742 0.179440047473463 no 2802 0.179168347891616 4006 441209 YML126C ERG13
SGTC_1302 1159-0335 255 µM -0.919996779205379 0.179066543728635 no 2803 0.178787221165132 3999 649284
SGTC_5 0352-0601 109.883 µM -0.921048225856907 0.17879743258682 no 2804 0.178512624628952 3919 762456
SGTC_171 k064-0041 9.68 µM -0.92388627517847 0.17807232360852 no 2805 0.177772764806461 4014 53325
SGTC_206 4546-0025 72.014 µM -0.9240404604918 0.178032983115557 no 2806 0.177732625240652 4051 6620745 YIL048W NEO1
SGTC_2331 7980721 200 µM -0.924189017091255 0.177995083976844 no 2807 0.177693956425384 3970 2981221
SGTC_1748 st037455 53.6035 µM -0.924300871861048 0.177966551412994 no 2808 0.17766484448421 4047 580690
SGTC_1335 1486-0900 202 µM -0.924436033602168 0.177932077420105 no 2809 0.177629670557413 3984 X1335
SGTC_185 k048-0037 25.491 µM -0.924953160884363 0.177800219199272 no 2810 0.17749513608669 4048 6827589
SGTC_1687 st020778 55.3625 µM -0.926680897728069 0.177360124306064 no 2811 0.177046119193353 4009 4259299
SGTC_2526 patulin 37.61 µM -0.927661884030241 0.177110550595149 no 2812 0.176791492999432 4055 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_421 streptovitacin 30 mM -0.928001409341608 0.177024223324482 no 2813 0.176703419280151 4086 91467 include heat shock
SGTC_1032 k061-1018 98.7 µM -0.930104411232496 0.176490109234197 no 2814 0.176158513520652 4121 4005393
SGTC_2030 5175110 200 µM -0.933953691500178 0.175515124164555 no 2815 0.175163890515795 4058 2831986
SGTC_18 0111-0177 500 nM -0.934611153311364 0.17534893748725 no 2816 0.174994364513213 4061 721752
SGTC_617 3770-0098 35 µM -0.935214127243243 0.175196611452306 no 2817 0.17483897971532 3936 5962639
SGTC_1955 wogonin 32.4 µM -0.935420709661157 0.175144442963897 no 2818 0.174785764115613 4108 5281703 A flavanone.
SGTC_1162 k048-0130 20.1 µM -0.935651775067368 0.175086103434491 no 2819 0.174726253884435 3978 6797406
SGTC_3077 9117319 49.47 µM -0.935670661274168 0.17508133557894 no 2820 0.174721390364871 3980 17154678
SGTC_3169 9102970 49.47 µM -0.9364324442168 0.174889090823544 no 2821 0.174525289945448 4071 17027839
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.936538004531849 0.174862462026246 no 2822 0.174498127327845 3966 756377
SGTC_3156 9099931 49.47 µM -0.942266984585721 0.173421121924851 no 2823 0.173027983414112 4034 18111053
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.942557043521113 0.173348348404379 no 2824 0.172953760316366 4026 6728940
SGTC_1509 1326-1131 80 µM -0.944930416641291 0.172753618174227 no 2825 0.172347200828881 3941 768313
SGTC_109 0132-0036 33.701 µM -0.946148754035357 0.172448827645648 no 2826 0.172036359892407 3826 67274 A color developer.
SGTC_127 0180-0333 59.125 µM -0.946719107541588 0.172306260684852 no 2827 0.171890965611957 3904 771601
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.947994412600111 0.171987754441472 no 2828 0.171566149330398 4009 140250 A respiratory chain inhibitor.
SGTC_458 nppb 133 µM -0.949761693502229 0.171546999456133 no 2829 0.171116677085705 4044 4549 A chloride channel blocker.
SGTC_1255 0566-0045 221 µM -0.949963571229762 0.171496697679695 no 2830 0.171065381527623 4077 2788469
SGTC_641 4092-0595 30 µM -0.951504580741859 0.171113035717739 no 2831 0.170674147145311 4061 786260
SGTC_3267 9137951 49.47 µM -0.951940440308449 0.171004620323546 no 2832 0.170563594294553 4059 16643986
SGTC_1991 st073000 8.92 µM -0.954980121342919 0.170249754436411 no 2833 0.169793874885767 4112 4301969 YIL048W NEO1
SGTC_280 3448-3607 3.04 µM -0.955749448629171 0.170059040902713 no 2834 0.169599416729076 4011 626179
SGTC_3035 9091303 49.47 µM -0.957430126012824 0.169642883387206 no 2835 0.169175099379232 4098 25237002
SGTC_3159 9100096 49.47 µM -0.957667642975148 0.16958412383523 no 2836 0.169115188951555 3985 25236875
SGTC_1556 plumbagin 1.48 µM -0.958739572583455 0.169319100588674 no 2837 0.168844978782129 3950 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_281 1672-3440 14.9 µM -0.9588545117026 0.169290698898371 no 2838 0.168816021602561 4082 6833000
SGTC_1373 2887-0003 58.5 µM -0.962030732202727 0.168507058456642 no 2839 0.168017083346616 4019 776948
SGTC_823 0417-1665 178 µM -0.965035768434076 0.167767803406881 no 2840 0.167263448334847 4030 3429856
SGTC_640 3381-0960 37.1 µM -0.96602071444951 0.167525956494433 no 2841 0.167016907927458 4098 1745025
SGTC_1371 2421-0008 32.7 µM -0.967904053365222 0.167064140861127 no 2842 0.166546144904793 4021 2827552
SGTC_628 1636-0253 16 µM -0.968167531419465 0.166999598630933 no 2843 0.166480353783278 4044 4456143
SGTC_3110 9122132 49.47 µM -0.973071371818278 0.16580127737309 no 2844 0.165258915601661 4163 918317
SGTC_2261 9010538 184.68 µM -0.973294381599554 0.165746914313488 no 2845 0.165203507011231 4063 6457250
SGTC_2766 oltipraz 83.91 µM -0.973662991509308 0.165657083602286 no 2846 0.165111949252176 4017 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3020 9089140 49.47 µM -0.977067419235458 0.164828908657427 no 2847 0.164267888108446 4107 17217859
SGTC_1974 st069448 26.9 µM -0.978076399033384 0.164583976189571 no 2848 0.164018269785154 4037 6323587 YNR016C ACC1
SGTC_1939 st074455 53.6 µM -0.978734454275308 0.164424358712285 no 2849 0.163855601712801 4094 1644229
SGTC_1271 0832-2808 169 µM -0.981150911103338 0.163839085547903 no 2850 0.163259163739285 4108 3663794
SGTC_2720 fluspirilene 36.88 µM -0.981630644740587 0.163723053658107 no 2851 0.163140922307718 4076 3396 An atypical antipsychotic.
SGTC_2073 5212005 126 µM -0.98282734051696 0.163433844612862 no 2852 0.16284621164052 3848 691789
SGTC_2654 protoveratrine a 100 µM -0.982896650607807 0.163417104407934 no 2853 0.162829153234187 4056 5702278 A heart drug and vasodilator.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.984988107939457 0.162912486500307 no 2854 0.162314956189219 3949 17037758
SGTC_1058 3448-5425 97.3 µM -0.986070296512177 0.162651778823929 no 2855 0.162049309208547 3952 7279705
SGTC_1249 0481-0015 10.2 µM -0.986184790730153 0.162624212157794 no 2856 0.162021220658425 4022 4227577
SGTC_2012 4023501 200 µM -0.987107468466447 0.162402170850602 no 2857 0.161794978437632 4096 3477460
SGTC_763 3453-1109 128 µM -0.987305851152969 0.162354456076624 no 2858 0.161746361552673 4103 1560353
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.987365462363755 0.16234012024037 no 2859 0.161731754721994 4073 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2313 7726885 200 µM -0.991284768259938 0.161399378707446 no 2860 0.160773274228583 4125 726423
SGTC_1868 st057644 42.7 µM -0.994604912819902 0.16060523949279 no 2861 0.159964228584955 4089 688665
SGTC_1077 5-fluorocytosine 377 nM -0.996378003876684 0.160182184349586 no 2862 0.159533258143684 4115 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_222 nsc-310342 10.666 µM -0.996915017096999 0.160054198182791 no 2863 0.15940288090995 4077 432556
SGTC_725 1497-0963 19 µM -0.997625378305477 0.159885000808158 no 2864 0.15923052507837 4188 3549977
SGTC_427 1354-0053 47.3 µM -0.997815019137663 0.159839851001945 no 2865 0.15918453293454 4167 6813657
SGTC_1623 st003709 20.3 µM -0.997904422737164 0.159818568630957 no 2866 0.159162853580093 4051 16192618
SGTC_2027 5150920 200 µM -0.999155121130738 0.1595210364272 no 2867 0.158859776245381 4022 786715
SGTC_1842 st055362 61.2 µM -1.00242262913223 0.158745431712793 no 2868 0.158069758683447 4061 676032
SGTC_1067 clotrimazole 1.36 µM -1.0025678693939 0.158711013676794 no 2869 0.158034702484687 4117 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_367 0335-0881 7.1 µM -1.00290835576521 0.158630346743067 no 2870 0.157952540337059 4070 23828853
SGTC_1830 st055982 50.3 µM -1.00331676142972 0.158533624058738 no 2871 0.157854025711456 4026 455313 An antimicrobial agent.
SGTC_1529 apigenin 74 µM -1.00422461544029 0.158318755638402 no 2872 0.157635179937343 4128 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2916 7875993 68.79 µM -1.00624938295147 0.157840227775402 no 2873 0.157147811237762 3940 1299250
SGTC_979 1426-2828 121 µM -1.00738323686689 0.157572671258223 no 2874 0.156875321874295 4194 747872
SGTC_2329 6138490 200 µM -1.00870497837634 0.157261155128029 no 2875 0.156558071756502 4221 720019
SGTC_1448 4255-0083 152 µM -1.01020070614194 0.156909121549608 no 2876 0.156199570517787 4179 5399660
SGTC_2112 5488546 200 µM -1.01049718148321 0.156839404910122 no 2877 0.156128574554403 4063 600757
SGTC_98 0074-0023 107.663 µM -1.0119856450768 0.156489698461785 no 2878 0.155772458528711 4124 3563821
SGTC_2487 5918373 44.05 µM -1.0143889150823 0.155926147763407 no 2879 0.155198605777632 4179 2876279
SGTC_1014 4130-3005 69.3 µM -1.01503268865253 0.155775414638685 no 2880 0.155045122821352 4115 743608
SGTC_2247 cerulenin 830 nM -1.01702016542535 0.155310673260291 no 2881 0.154571918255133 4170 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2860 9025725 38.96 µM -1.01842661060236 0.154982350791431 no 2882 0.154237630664812 4135 40546248
SGTC_720 r052-1644 49.9 µM -1.01852156314634 0.154960201469973 no 2883 0.154215079336627 4137 1422863 YOR257W CDC31
SGTC_2284 7945075 39.21 µM -1.01872907355154 0.154911803359638 no 2884 0.154165802990011 4113 1245402
SGTC_129 0088-0017 176.636 µM -1.01886585768029 0.154879906355191 no 2885 0.154133327316251 3966 182446
SGTC_365 0121-0052 13.6 µM -1.01943663535977 0.154746852223814 no 2886 0.1539978605129 4149 3101739
SGTC_1015 4130-4525 82 µM -1.0194599112111 0.154741427987243 no 2887 0.153992337958675 4115 1363237
SGTC_2080 5212524 12.4 µM -1.0196468773148 0.154697861705294 no 2888 0.153947982124801 3995 260183
SGTC_2001 4023502 57.655 µM -1.02099955241041 0.154382906856178 no 2889 0.153627325385954 4151 108941 YCR052W RSC6
SGTC_1658 st012944 20 µM -1.02235082897491 0.15406870123264 no 2890 0.153307442035197 3981 24207260
SGTC_1182 1222-0449 220 µM -1.023389168684 0.153827548904274 no 2891 0.153061939264148 4112 658318
SGTC_372 0155-0182 15.9 µM -1.02374290726435 0.153745450908363 no 2892 0.152978361632796 4023 771486
SGTC_1574 spiramycin 23.7 µM -1.02823469502958 0.15270548989572 no 2893 0.151919720866321 4086 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_183 3914-0051 30.55 µM -1.02942049105907 0.152431728828005 no 2894 0.151641062107937 4153 1596232
SGTC_3013 9080133 71.4286 µM -1.0357282492764 0.150980953564022 no 2895 0.15016446970829 4217 17050193
SGTC_861 0443-0273 110 µM -1.03830130529494 0.150391801869076 no 2896 0.149564900598324 4120 6149169
SGTC_3208 9114115 49.47 µM -1.03850343337135 0.150345585655309 no 2897 0.149517868831432 4144 650895
SGTC_1628 st004252 77.7 µM -1.03904687262515 0.150221376197449 no 2898 0.149391468703946 4159 692968
SGTC_3232 9132874 49.47 µM -1.03990772419605 0.150024758425204 no 2899 0.149191386752395 4088 3784940
SGTC_1156 4092-0367 4.88 µM -1.04122101082529 0.149725135555982 no 2900 0.148886493256213 4146 1357585
SGTC_2536 dehydroabietamide 32.04 µM -1.04238068954923 0.149460890042903 no 2901 0.148617607860798 4232 3983547
SGTC_3115 9123671 49.47 µM -1.04252558691403 0.149427895479267 no 2902 0.148584034502087 4252 3286988
SGTC_113 0099-0221 2.5 µM -1.04289303742875 0.149344245161354 no 2903 0.148498917332909 4068 89219
SGTC_295 k015-0027 31 µM -1.0435120528134 0.149203396665437 no 2904 0.148355600782994 4167 3887424
SGTC_3231 9132313 49.47 µM -1.04377398601974 0.149143824060186 no 2905 0.148294984980598 4100 4905967
SGTC_1829 berberine 14.4 µM -1.04506425491223 0.148850604493381 no 2906 0.14799663663675 4135 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2752 diclazuril 33.15 µM -1.04520451951842 0.148818751944675 no 2907 0.147964227538091 4098 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1653 st012112 65 µM -1.0459367057665 0.148652554457969 no 2908 0.14779512801515 4129 720429
SGTC_1281 0884-0031 11.8 µM -1.04680526791885 0.148455562232537 no 2909 0.147594700132461 4151 1548255
SGTC_1142 3253-1408 9.78 µM -1.04700730765363 0.148409764118118 no 2910 0.147548103910495 4155 256655
SGTC_1413 3910-0535 34.4 µM -1.05209854473931 0.147258807959739 no 2911 0.146377169879463 4153 2876951
SGTC_1946 st076057 65.1 µM -1.05315800232641 0.147020054568513 no 2912 0.146134291535321 4083 953009
SGTC_1948 st076329 66.6 µM -1.05464572522776 0.146685228129565 no 2913 0.145793691496024 4008 24208413
SGTC_2746 daunorubicin 9.88 µM -1.05535918493255 0.146524838785558 no 2914 0.145630541118175 4092 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2373 9071805 200 µM -1.05622093586696 0.146331269835667 no 2915 0.145433643983327 4165 10149009
SGTC_310 1273-0058 1.06 µM -1.05801112391016 0.145929701762866 no 2916 0.145025185499832 4004 2734232
SGTC_1836 st055642 81 µM -1.05910307210653 0.145685124092379 no 2917 0.144776420512733 4161 8571
SGTC_1191 1487-1166 10.6 µM -1.05976718697437 0.145536508596362 no 2918 0.144625264091863 4195 3955771
SGTC_3143 9086658 49.47 µM -1.06056335647159 0.14535847635912 no 2919 0.144444191435376 4201 25236626
SGTC_2635 hydroquinidine 100 µM -1.06078177741511 0.145309660658745 no 2920 0.144394542723086 4082 442912 An experimental heart treatment.
SGTC_1835 st008666 49.2 µM -1.06122902705251 0.145209737608747 no 2921 0.144292915428383 4093 690455
SGTC_1100 amiodarone 5.07 µM -1.06141576343394 0.145168031263168 no 2922 0.144250498109165 4249 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1727 st034309 9.9045 µM -1.0626949224498 0.144882556235094 no 2923 0.143960162123996 4226 870305
SGTC_2866 9034245 58.44 µM -1.06428776867716 0.144527603106464 no 2924 0.143599178593777 4118 6462273
SGTC_2899 9053889 58.44 µM -1.07122142228584 0.142989323809887 no 2925 0.142034940757364 4152 6470052
SGTC_1090 efavirenz 20.7 µM -1.07325364847503 0.142540564498704 no 2926 0.14157866290811 4192 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2375 9072683 200 µM -1.07396773468348 0.142383105269483 no 2927 0.141418571459354 4245 16798029
SGTC_976 1348-1067 47.6 µM -1.07399288552485 0.142377561541548 no 2928 0.141412935113465 4173 5310671 YGL099W LSG1
SGTC_960 1222-0186 7.7 µM -1.07413333617879 0.142346606207508 no 2929 0.141381462684443 4201 3126296
SGTC_1756 st041558 35.5 µM -1.07485711603249 0.142187157270009 no 2930 0.141219352095296 4259 3955792
SGTC_1449 4112-4002 201 µM -1.07492063450347 0.142173169901584 no 2931 0.141205131387969 4225 2059539
SGTC_253 dyclonine 31.25 µM -1.07523129704235 0.142104772485584 no 2932 0.141135593306286 4259 3180 An oral anasthetic.
SGTC_1635 st007035 42.4 µM -1.07531761770979 0.142085771539789 no 2933 0.141116275583751 4146 3716403
SGTC_2622 2-methoxyxanthone 59.94 µM -1.07542661161451 0.142061782207005 no 2934 0.141091886373418 4164 71034 A hepatoprotective.
SGTC_1393 3470-5649 58.2 µM -1.0775517423133 0.141594593175992 no 2935 0.140616923990329 4144 4108395
SGTC_1522 st012842 45.6 µM -1.07816202940976 0.141460620176401 no 2936 0.140480726872458 4019 3491067 YOR116C RPO31
SGTC_2759 disulfiram 3.38 µM -1.07940594228619 0.141187816816229 no 2937 0.140203401549236 4073 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_670 4204-0025 119 µM -1.08049502319257 0.140949262804056 no 2938 0.139960900905054 4181 719039
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.08377449838022 0.140232573261222 no 2939 0.1392323974211 4278 5282309
SGTC_201 4262-0159 12.803 µM -1.08403902779875 0.140174871636354 no 2940 0.139173747454826 4206 1341029
SGTC_1144 3486-0183 12.5 µM -1.08417407111803 0.14014542094681 no 2941 0.139143812897627 4169 6744069
SGTC_1637 st007924 17.4 µM -1.08430226887109 0.140117467050247 no 2942 0.139115399826797 4099 683336
SGTC_1476 4112-3294 3.34 µM -1.08570096510097 0.13981272335252 no 2943 0.138805656788773 4185 704369
SGTC_926 2268-1401 59.4 µM -1.0875119030773 0.139418831410648 no 2944 0.138405320494653 4147 2931578
SGTC_868 0527-0199 213 µM -1.08822808387905 0.13926326547244 no 2945 0.138247214831941 4141 2849450
SGTC_1654 st012436 41.8 µM -1.08976711979565 0.138929361990899 no 2946 0.137907870585648 4174 4323132
SGTC_153 4077-0274 519.67 µM -1.09201358924533 0.138442955608452 no 2947 0.137413564093966 4200 3121976
SGTC_1877 wortmannin 25 µM -1.09347782911771 0.138126543331502 no 2948 0.137092029088316 4195 312145 A covalent inhibitor of PI 3-kinase.
SGTC_527 4476-4215 268 µM -1.09479913739028 0.137841441179578 no 2949 0.136802322220483 4171 4418754
SGTC_2665 lovastatin 100 µM -1.0970030907352 0.137366782290004 no 2950 0.136320020505335 4199 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2198 6589944 200 µM -1.0971142593337 0.137342869843858 no 2951 0.136295723804985 4183 5290268
SGTC_2374 9071832 200 µM -1.1017441012021 0.136349511387399 no 2952 0.135286469137099 4129 17381698
SGTC_1958 st076513 41.9 µM -1.10210318717478 0.136272673408701 no 2953 0.135208406975947 4151 732122 YGL099W LSG1
SGTC_2513 baicalein 25.65 µM -1.10327068572201 0.13602305438581 no 2954 0.134954816419382 4211 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.10436194027024 0.135790020024147 no 2955 0.134718081856352 4297 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1646 st011709 75.6 µM -1.10474351690932 0.135708599954262 no 2956 0.134635370672873 4152 5757843
SGTC_884 0851-0618 334 µM -1.10865517351895 0.134875866804321 no 2957 0.133789483370563 4218 9642473
SGTC_2354 9060492 162 µM -1.10911514464292 0.134778176669145 no 2958 0.133690256184049 4238 6471895
SGTC_3187 9109394 49.47 µM -1.10955423181189 0.134684967238201 no 2959 0.133595581399382 4208 17098090
SGTC_2162 5663267 200 µM -1.11002919279542 0.134584192330497 no 2960 0.133493223518616 4204 6456493
SGTC_343 4130-2827 29.8 µM -1.11027289038737 0.134532505857841 no 2961 0.133440725686319 4215 1118244
SGTC_2706 st078239 82.5 µM -1.11122852209263 0.134329954871444 no 2962 0.133234998592487 4188 15434492
SGTC_2798 7813637 45.45 µM -1.11431694245667 0.133676781035336 no 2963 0.132571620558452 4199 956368
SGTC_1244 0416-0015 52.5 µM -1.11714807103468 0.13307994346128 no 2964 0.131965509801131 4182 96201
SGTC_959 1222-0044 107 µM -1.11808493597188 0.13288284504124 no 2965 0.131765359762301 4207 6083612
SGTC_657 3534-0529 86.7 µM -1.11835239582917 0.13282661351527 no 2966 0.131708258600456 4260 1049549
SGTC_2129 girgensonine 121.053 µM -1.11963347055051 0.132557503917084 no 2967 0.131434993189982 4219 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_593 1203-0218 61.7 µM -1.12318592659096 0.131813221473981 no 2968 0.13067926918871 4235 3666956
SGTC_1468 k284-1086 134 µM -1.12422306947013 0.131596472294844 no 2969 0.130459202515797 4201 15996457
SGTC_717 1532-0246 73.2 µM -1.12539733380558 0.13135136361097 no 2970 0.13021035019778 4193 9561992
SGTC_3107 9121808 49.47 µM -1.12545762710936 0.131338786873159 no 2971 0.130197581598072 4143 662681
SGTC_1134 3477-0009 42.5 µM -1.12708716875995 0.130999191419494 no 2972 0.12985281391851 4297 3973534
SGTC_688 0527-0193 473 µM -1.12787295494834 0.13083565107299 no 2973 0.129686788556595 4269 4007154
SGTC_2108 5365811 200 µM -1.13018474595182 0.130355332157337 no 2974 0.129199193000038 4223 780283
SGTC_1288 0973-0013 65.5 µM -1.13221224128656 0.129935086273926 no 2975 0.128772607428404 4251 4315430
SGTC_135 0933-0004 26.348 µM -1.13293241975676 0.129786038413096 no 2976 0.128621317131452 4197 21230617 YGL099W LSG1
SGTC_1050 3232-1156 69.3 µM -1.13591088036359 0.129170874891083 no 2977 0.127996932107331 4215 700529
SGTC_3053 9095903 49.47 µM -1.13747219928531 0.128849212922792 no 2978 0.127670470003594 4339 17174018
SGTC_1798 st045719 60.953 µM -1.13838916778246 0.128660558828192 no 2979 0.127479007597929 4159 3980186
SGTC_2348 9022543 33.42 µM -1.13841594267294 0.128655053131395 no 2980 0.127473420020577 4260 3162678 YDL140C RPO21
SGTC_585 0kpi-0023 191 µM -1.13940485816956 0.12845181784198 no 2981 0.127267165299808 4161 64601
SGTC_1454 4239-0054 42.6 µM -1.14044218933532 0.128238872094883 no 2982 0.127051062295183 4337 1340767
SGTC_1326 1431-2094 10.8 µM -1.14057105106327 0.128212436188531 no 2983 0.127024234895412 4219 616278
SGTC_2202 7226349 200 µM -1.1449415641798 0.127318068286532 no 2984 0.126116682391411 4194 844334
SGTC_796 1234-0020 70.7 µM -1.14518187572328 0.127269017877003 no 2985 0.126066912287751 4174 46495034
SGTC_2160 5660466 132.927 µM -1.14536313880159 0.127232028651525 no 2986 0.126029380570959 4160 2859134
SGTC_3008 9078912 71.4286 µM -1.14553490241801 0.127196984824026 no 2987 0.125993822969914 4233 16648731
SGTC_2544 sphondin 68.51 µM -1.14632266880753 0.127036347937749 no 2988 0.125830833325114 4224 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1199 1638-0010 4.46 µM -1.14642876354923 0.127014724487928 no 2989 0.125808893459928 4211 3111136
SGTC_841 0251-0215 91.2 µM -1.14742485418651 0.126811833543953 no 2990 0.125603036989158 4278 3888614
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.14848965340461 0.126595197187435 no 2991 0.125383240935779 4295 279621
SGTC_485 niflumic acid 177 µM -1.15008964563085 0.126270159223559 no 2992 0.125053475302028 4291 4488 A COX2 inhibitor.
SGTC_551 k048-0028 34.9 µM -1.15160874018605 0.125962094264947 no 2993 0.124740944098786 4228 6836383
SGTC_2569 tetrandrine 100 µM -1.15678412324878 0.124916487765906 no 2994 0.123680285012724 4256 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_212 3807-4682 38.772 µM -1.15724606442019 0.124823455303074 no 2995 0.123585921257125 4315 3125501 YBL034C STU1
SGTC_2257 7960413 200 µM -1.15743643301929 0.124785130183399 no 2996 0.123547048088021 4268 2974689 YIL048W NEO1
SGTC_2166 5933061 31.504 µM -1.15792567343957 0.124686673734152 no 2997 0.123447184734639 4389 2877375
SGTC_1678 st019265 80.2 µM -1.15857928397698 0.124555223608116 no 2998 0.123313858537415 4245 5367020
SGTC_143 4032-1194 15.74 µM -1.16109441487854 0.124050299775745 no 2999 0.122801752899068 4272 1806963
SGTC_2031 5180455 200 µM -1.16236060182339 0.12379664979093 no 3000 0.122544509852141 4212 29949
SGTC_2521 angolensin 13.4 µM -1.16237605237117 0.123793556890588 no 3001 0.122541373200544 4299 821428 A flavenoid.
SGTC_2311 7694451 200 µM -1.16594801397216 0.123079970748145 no 3002 0.121817732334556 4229 2163142
SGTC_2326 6164455 177.58 µM -1.16666038952504 0.122938001961829 no 3003 0.121673772553381 4213 2888790
SGTC_594 1487-1584 10.8 µM -1.16749166662525 0.122772482583926 no 3004 0.121505935860113 4208 5013332
SGTC_2078 5212016 200 µM -1.1683686425891 0.122598033382148 no 3005 0.121329048943326 4135 1899708
SGTC_1323 1348-1351 11.2 µM -1.16916926719997 0.122438924006869 no 3006 0.121167720351479 4226 6989654
SGTC_3270 9137563 49.47 µM -1.17407422344503 0.12146731769205 no 3007 0.120182648548613 4245 17015724
SGTC_2219 9098279 200 µM -1.17498911537341 0.121286691265646 no 3008 0.119999535245113 4203 902349
SGTC_1540 guanosine 70.6 µM -1.17638486449394 0.121011493593893 no 3009 0.119720558590596 4169 6802 Guanosine is a purine nucleoside
SGTC_2117 5521686 200 µM -1.18050355083325 0.120201980585854 no 3010 0.118899999514475 4232 803312
SGTC_1552 6-methylflavone 10.6 µM -1.18234883941343 0.119840536184059 no 3011 0.118533657064379 4215 689013
SGTC_1833 st055984 71 µM -1.1884058753673 0.118659507318754 no 3012 0.117336771391931 4275 676288
SGTC_2755 lomerizine 42.69 µM -1.19024418477002 0.118302697392861 no 3013 0.116975215682165 4233 3949 A calcium channel blocker.
SGTC_2859 9028643 45.46 µM -1.191841183129 0.117993341453888 no 3014 0.116661762097307 4125 17151580
SGTC_2017 5132927 60.65 µM -1.19222553509902 0.11791897381117 no 3015 0.116586411758152 4263 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_7 0192-1582 4.227 µM -1.19282049438094 0.117803921505121 no 3016 0.116469840951344 4322 252616
SGTC_2492 derrusnin 100 µM -1.19551313477658 0.117284216182451 no 3017 0.115943303766335 4297 1715307 Part of coumarin class of compounds.
SGTC_1791 st048313 56.1 µM -1.19799213141647 0.116807183786883 no 3018 0.115460040136767 4287 1204976
SGTC_1117 retinoic acid 1.10837 µM -1.19817209859814 0.11677260639702 no 3019 0.115425012562047 4318 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1319 1306-0155 43.7 µM -1.20056280293783 0.116313964790051 no 3020 0.114960418641666 4326 3122360
SGTC_3287 9117173 37.0625 µM -1.20078779235592 0.116270867876781 no 3021 0.114916764234074 4286 2789709
SGTC_2890 9046729 58.44 µM -1.20263515690972 0.115917432066395 no 3022 0.11455876829867 4248 903329
SGTC_2676 harmalol 100 µM -1.20499431707511 0.115467190061678 no 3023 0.114102747881495 4245 5459187 A monoamine oxidase inhibitor
SGTC_562 3772-2733 112 µM -1.20533501690181 0.115402270866159 no 3024 0.114036998363002 4278 2876874 YIL048W NEO1
SGTC_40 0327-0103 19.753 µM -1.20609781753144 0.115257015857162 no 3025 0.113889888137732 4144 409036
SGTC_1474 0330-0125 5.35 µM -1.20947080348251 0.114616278769637 no 3026 0.113241010678687 4327 X1474
SGTC_659 k018-0002 107 µM -1.21075669152659 0.114372678344052 no 3027 0.112994333946869 4266 6797879 YHR007C ERG11
SGTC_1920 st075728 45.7 µM -1.2145305285106 0.113659886422235 no 3028 0.112272599684092 4283 3400306
SGTC_2594 a-mangostin 100 µM -1.21511076353993 0.113550574724413 no 3029 0.112161924447437 4326 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2404 5161160 200 µM -1.21519366278489 0.113534963283133 no 3030 0.112146118441813 4244 2831543
SGTC_1089 terbinafine 2.25 µM -1.21600895038509 0.113381511276085 no 3031 0.111990756244717 4312 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1569 carminic acid 40.6 µM -1.21692849747285 0.113208613307479 no 3032 0.111815710969067 4378 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_503 tyrphostin 8 294 µM -1.21862870534447 0.112889427086447 no 3033 0.111492574427263 4312 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2048 5246248 200 µM -1.21996511259489 0.112638989798644 no 3034 0.111239050257503 4322 677046
SGTC_2933 9026794 32.47 µM -1.22382813987432 0.111917305996258 no 3035 0.110508533248397 4255 17586027
SGTC_2471 5466956 24.79 µM -1.22387948042112 0.111907736963139 no 3036 0.110498847716465 4289 724419
SGTC_532 1548-0774 215 µM -1.22684918019272 0.111355229122907 no 3037 0.109939641157652 4408 5932993
SGTC_1208 2323-2347 50.3 µM -1.22825999989191 0.111093433644477 no 3038 0.109674690785259 4306 5412760
SGTC_2597 laccaic acid a 100 µM -1.22853325792558 0.11104277814674 no 3039 0.109623426267231 4302 5491415 A textile dye.
SGTC_736 0958-0254 92.6 µM -1.22927083886825 0.110906130889666 no 3040 0.109485138443681 4379 6812352
SGTC_683 panaxydol 45 µM -1.23178198015597 0.110441809897158 no 3041 0.109015268188058 4319 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3031 9088762 49.47 µM -1.2350890061516 0.109832454938485 no 3042 0.108398690258998 4280 205253
SGTC_2698 st077697 67.5 µM -1.23723053660718 0.109439144488264 no 3043 0.108000753897772 4281 3154499
SGTC_908 3448-7491 47.7 µM -1.23855271702216 0.109196820346365 no 3044 0.107755593875848 4315 1203031
SGTC_1632 st005650 90 µM -1.24034276310893 0.108869362242307 no 3045 0.107424320867678 4347 2759605
SGTC_2546 rhodinyl acetate 100 µM -1.24308457047818 0.108369165620394 no 3046 0.10691833546161 4258 6708682
SGTC_872 0588-0139 234 µM -1.24442946313706 0.108124418004943 no 3047 0.106670772427981 4279 2047100
SGTC_2008 4012253 172 µM -1.24637243709744 0.107771532848726 no 3048 0.106313847727068 4317 603940
SGTC_3350 9150499 3.57 µM -1.24775407737413 0.107521102984329 no 3049 0.106060565394434 4332 4910996 YPR165W RHO1
SGTC_1228 0124-0032 52.5 µM -1.24899494285631 0.107296547015193 no 3050 0.105833461765485 4377 X1228
SGTC_2074 5212007 75.395 µM -1.25351304181504 0.106481776356275 no 3051 0.105009527895981 4227 758611
SGTC_1347 1493-0251 600 nM -1.25630243295469 0.105980987443056 no 3052 0.104503170082853 4373 3986378
SGTC_3233 9132340 49.47 µM -1.25661714120556 0.105924593815542 no 3053 0.104446152374477 4335 17682950
SGTC_1796 st049173 110.4 µM -1.26045330611891 0.105238921216365 no 3054 0.103752941117901 4303 94134
SGTC_1744 st037937 38.9 µM -1.26080217044026 0.105176725205295 no 3055 0.103690065817566 4374 1016152
SGTC_452 diindolylmethane 8 µM -1.26083986159387 0.10517000716705 no 3056 0.103683274451804 4330 3071 Inhibits expression of several cancer promoting factors.
SGTC_653 0203-0016 55.2 µM -1.26093137490846 0.105153697206182 no 3057 0.103666786504095 4406 295302
SGTC_773 4358-1457 44.6 µM -1.26176677230704 0.105004893118244 no 3058 0.103516360953809 4342 1186886
SGTC_1807 st050092 58.9 µM -1.26392841379554 0.104620561129956 no 3059 0.103127861128014 4347 5008496
SGTC_2338 7999974 200 µM -1.26668535465069 0.10413186693885 no 3060 0.102633909368466 4335 315925
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.26715650295696 0.104048517231237 no 3061 0.10254966766643 4374 5393153
SGTC_2626 ethyl orsellinate 100 µM -1.26832834526674 0.10384141924674 no 3062 0.102340359323931 4297 75653 A natural product.
SGTC_993 3909-8757 62.7 µM -1.27698657464639 0.102320523030241 no 3063 0.10080349353721 4280 4288324 YLR208W SEC13
SGTC_3211 9128781 49.47 µM -1.2839603915588 0.10110733900056 no 3064 0.0995779073037169 4312 17194361
SGTC_2328 6201408 200 µM -1.28922797024216 0.100197951116671 no 3065 0.0986594218988385 4338 2890418
SGTC_881 0833-0569 170 µM -1.29293195032439 0.0995620857781294 no 3066 0.09801729796111 4379 5418700
SGTC_2484 5809818 12.04 µM -1.29368946971124 0.0994324058182324 no 3067 0.0978863520537752 4317 2870548
SGTC_261 5-fluorouridine 15.376 µM -1.29555112778271 0.099114232687529 no 3068 0.0975650879585796 4375 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_105 0111-0055 734.78 µM -1.29921707656966 0.0984898690602401 no 3069 0.0969347213593758 4383 5179370
SGTC_2152 5568786 200 µM -1.30513334735088 0.0974883250908075 no 3070 0.0959237226587117 4391 5399883
SGTC_1132 3456-3614 2.5 µM -1.30598313042207 0.0973450841353975 no 3071 0.0957791472202245 4381 3125502
SGTC_2663 amphotericin b 100 µM -1.30686294566395 0.0971969436521342 no 3072 0.0956296313047116 4393 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_798 1287-0182 476 µM -1.3099155979501 0.0966842306198259 no 3073 0.0951121949178489 4412 1649755
SGTC_2511 berberine 10.47 µM -1.31123035113638 0.096464022225105 no 3074 0.0948899755597349 4352 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2319 6033012 152.6 µM -1.3142807226649 0.0959545343793603 no 3075 0.0943758760362306 4326 847246
SGTC_586 0957-0265 8.15 µM -1.31451335498982 0.0959157603697135 no 3076 0.0943367534136153 4245 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1575 cyproterone acetate 48 µM -1.31659006353775 0.095570135296609 no 3077 0.093988035634695 4386 9880 An androgen receptor antagonist and liver toxin.
SGTC_170 4197-0004 226 µM -1.31668534835709 0.0955542991339185 no 3078 0.0939720584052762 4369 218692
SGTC_229 benomyl 22.8748 µM -1.31858067942856 0.0952396997078303 no 3079 0.093654668181238 4393 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_355 1311-2252 105 µM -1.32193033083484 0.0946855688409705 no 3080 0.0930956756700015 4356 5338538
SGTC_1141 3253-0389 52.6 µM -1.322049741479 0.0946658587664249 no 3081 0.0930757939446959 4372 5402031
SGTC_2260 7964312 200 µM -1.3279249910805 0.0936998136858131 no 3082 0.0921014439109836 4438 231951
SGTC_2522 biochanin a 4.94 µM -1.33007880882376 0.0933474988851966 no 3083 0.0917461533874837 4394 5280373 A possible chelator.
SGTC_878 0828-0289 13.7 µM -1.33280501689667 0.0929029588153281 no 3084 0.0912978994660354 4338 745350 YLR208W SEC13
SGTC_1793 st048256 72.231 µM -1.33323952326389 0.0928322523257002 no 3085 0.0912266064846093 4345 672022
SGTC_24 0417-1663 219 µM -1.33507486438538 0.0925340293354492 no 3086 0.090925922596333 4414 4329390
SGTC_3310 9130229 44.1445 µM -1.33596068005025 0.0923903477629519 no 3087 0.0907810627774868 4414 7761258
SGTC_2287 7945887 168.79 µM -1.34678172382055 0.09064845382172 no 3088 0.0890252712795535 4416 1245853
SGTC_701 4424-0219 185 µM -1.34966460630183 0.0901885266101484 no 3089 0.0885617951734241 4418 2911779
SGTC_2493 resveratrol 26.09 µM -1.3500076987222 0.0901339062120942 no 3090 0.0885067566971362 4326 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_933 2914-0560 114 µM -1.35050754632137 0.090054374337908 no 3091 0.0884266173545317 4402 463887
SGTC_2960 9079389 5.97 µM -1.35112455007774 0.0899562734045946 no 3092 0.0883277692282923 4388 16457355
SGTC_2136 5328288 199.296 µM -1.35309969045537 0.0896427686400442 no 3093 0.0880118922714673 4378 262395
SGTC_462 ag-879 158 µM -1.35340636298833 0.0895941648963407 no 3094 0.0879629228964382 4444 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2221 6807166 181.081 µM -1.35906611852554 0.0887006795301579 no 3095 0.0870628190013068 4380 674925
SGTC_2109 5483026 200 µM -1.36174614189086 0.0882799162381964 no 3096 0.086639006944928 4408 759335
SGTC_1157 4092-0394 27.6 µM -1.3621642846986 0.0882144022519992 no 3097 0.0865730222057308 4462 3659885
SGTC_1470 k295-0292 231 µM -1.36361804515056 0.0879869112670278 no 3098 0.0863439048661947 4481 5045612
SGTC_2165 5727197 32.143 µM -1.36678965247797 0.0874921226067271 no 3099 0.0858456235367216 4482 1361712
SGTC_1057 3448-5381 134 µM -1.36826333479896 0.0872629276909597 no 3100 0.0856148315722762 4387 5497911
SGTC_833 3852-0053 558 µM -1.36910652659385 0.0871319917939201 no 3101 0.0854829892448091 4481 3123681
SGTC_156 3474-0145 5.642 µM -1.37083208697368 0.0868644938378714 no 3102 0.0852136529516091 4337 2265471
SGTC_2063 5246145 200 µM -1.37253061001431 0.0866017869232368 no 3103 0.0849491582909248 4455 711240
SGTC_69 0096-0274 206.684 µM -1.37357697292063 0.0864402441001318 no 3104 0.0847865248757672 4515 6741392
SGTC_2330 7979373 200 µM -1.37492705110918 0.0862321451910296 no 3105 0.0845770308912952 4348 1863007
SGTC_2742 clothiapine 36.27 µM -1.37643514096119 0.0860001339318185 no 3106 0.084343477328279 4451 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2833 9001315 45.46 µM -1.37907711149221 0.085594807807837 no 3107 0.0839354900116099 4357 2989378
SGTC_2998 9066762 71.4286 µM -1.38404517381848 0.0848364937275373 no 3108 0.0831723114917149 4450 4945196
SGTC_647 0140-0236 81 µM -1.38499821613894 0.0846916010396434 no 3109 0.0830265064133725 4439 990837
SGTC_1412 3909-8563 178 µM -1.38692818631872 0.0843987528750306 no 3110 0.082731831004095 4515 23767530
SGTC_158 k038-0087 26.446 µM -1.38784630993139 0.0842597064090069 no 3111 0.0825919248532061 4341 X158
SGTC_2432 5630864 12.22 µM -1.3883551856731 0.0841827131284836 no 3112 0.082514457740189 4426 5714970
SGTC_1663 st014140 55.4 µM -1.38950714615675 0.0840086157447358 no 3113 0.0823392947059202 4491 4207120
SGTC_1432 4049-0298 68.4 µM -1.38975443499096 0.0839712779114084 no 3114 0.0823017293731288 4441 741646
SGTC_420 mitomycin C 81.9 mM -1.39102272777377 0.0837799757870488 no 3115 0.0821092674494035 4413 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2482 5981709 142.65 µM -1.39949080898562 0.0825110796894834 no 3116 0.0808329262915048 4373 877755
SGTC_553 k007-0256 45.7 µM -1.39994210672477 0.0824438634692081 no 3117 0.0807653277984346 4485 6287000
SGTC_3213 9129884 49.47 µM -1.40048193495143 0.0823635156903898 no 3118 0.0806845246753372 4418 17190742
SGTC_2218 6965428 192.983 µM -1.40479159858197 0.0817241805168534 no 3119 0.0800416290401986 4349 675684
SGTC_1349 flufenamic acid 69 µM -1.40513426822041 0.0816735067528946 no 3120 0.0799906778622428 4368 3371 A non-steroidal anti-inflammatory.
SGTC_2939 9044578 71.43 µM -1.41090318175121 0.0808239561067612 no 3121 0.0791365819389611 4371 2653634
SGTC_3244 9134489 49.47 µM -1.41129320015475 0.0807667623028535 no 3122 0.0790790893330093 4457 16584271
SGTC_2459 5811157 9.22 µM -1.41134792044486 0.0807587403535375 no 3123 0.0790710255469554 4387 2870684 YBR192W RIM2
SGTC_1802 st050112 57.9 µM -1.41217035015119 0.0806382453004727 no 3124 0.0789499042397486 4450 4662563
SGTC_1896 st058441 89 µM -1.41270546605708 0.0805599178451244 no 3125 0.0788711718660574 4455 688759
SGTC_2570 licareol 100 µM -1.41295692279328 0.0805231307829618 no 3126 0.0788341952235718 4404 443158
SGTC_1527 coumarin 137 µM -1.41393155466734 0.0803806661465792 no 3127 0.0786909999808262 4478 323 A hepatotoxic, DNA x-linker.
SGTC_779 1360-0071 233 µM -1.41540551204685 0.0801655756387853 no 3128 0.0784748172155872 4467 7566
SGTC_895 0964-0006 13.7 µM -1.41571061195686 0.0801211076527671 no 3129 0.0784301250395302 4442 6738897
SGTC_3139 9095020 49.47 µM -1.41650201605961 0.0800058482655415 no 3130 0.0783142871557677 4310 25236292
SGTC_1187 1391-0724 117 µM -1.41738874083863 0.0798768554332428 no 3131 0.0781846513469624 4495 6997986
SGTC_2430 5571206 200 µM -1.41816721864054 0.0797637391158089 no 3132 0.0780709750658807 4422 1731771
SGTC_1997 st073024 93.8 µM -1.4187866916115 0.0796738135184076 no 3133 0.0779806068947111 4490 686268
SGTC_1753 st043925 64 µM -1.41986177978897 0.079517930773315 no 3134 0.0778239624058774 4468 670181
SGTC_1375 2910-0797 186 µM -1.4221787372292 0.0791827676202945 no 3135 0.0774871848762028 4438 742508
SGTC_1900 st060200 72.8 µM -1.42242813646655 0.0791467542393102 no 3136 0.0774509999397719 4424 688945
SGTC_1254 0550-0035 264 µM -1.42395550346892 0.0789264721564521 no 3137 0.0772296766003245 4453 15121435
SGTC_2075 5212009 200 µM -1.42566849797845 0.0786799711062787 no 3138 0.0769820268954879 4383 780898
SGTC_2100 5377183 190 µM -1.42625772526793 0.0785953159019608 no 3139 0.0768969812529362 4482 2844202
SGTC_2689 tacrolimus 100 µM -1.42666544214591 0.078536779006313 no 3140 0.0768381755901549 4451 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1010 4112-3296 15.2 µM -1.42872933929253 0.0782409672785106 no 3141 0.0765410208467608 4486 704384
SGTC_660 4031-1742 102 µM -1.43494093093056 0.0773557782076228 no 3142 0.0756519653385333 4337 6738706
SGTC_1530 rhein 70.4 µM -1.4356181394232 0.0772597336678239 no 3143 0.0755555151199153 4530 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2170 morpholine 200 µM -1.43745548673696 0.0769996097288892 no 3144 0.0752943061489988 4490 121171 Reacts with secondary amines.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.43993287654183 0.0766499258157719 no 3145 0.0749431952752899 4410 6708739 YPR165W RHO1
SGTC_2740 felodipine 17.08 µM -1.44069171960051 0.0765430570009228 no 3146 0.0748358976286583 4512 3333 L-type calcium channel blocker
SGTC_2292 7671323 168.05 µM -1.44193762802535 0.076367840021637 no 3147 0.0746599849472893 4481 937504
SGTC_2431 5490079 200 µM -1.44257705569692 0.0762780333943603 no 3148 0.0745698253071636 4496 5722345
SGTC_31 0508-1974 57.237 µM -1.44323550361255 0.0761856394182059 no 3149 0.0744770706749733 4410 6810525
SGTC_1685 st024049 53.0905 µM -1.45010003851325 0.0752274690335138 no 3150 0.0735153121947043 4483 1941139
SGTC_1651 st011928 86.1 µM -1.45043375261098 0.075181123567395 no 3151 0.0734688002539831 4475 720198
SGTC_2892 9047358 58.44 µM -1.45044642130552 0.0751793645964907 no 3152 0.0734670349777268 4478 6466771
SGTC_801 0866-0028 10.1 µM -1.45055992395983 0.0751636068456759 no 3153 0.0734512207825904 4501 6849771
SGTC_832 4083-0019 164 µM -1.45228171675645 0.0749248764202808 no 3154 0.0732116445284222 4543 1990758
SGTC_176 1486-1328 72.834 µM -1.45238874965063 0.074910055186775 no 3155 0.073196771359264 4494 22310231
SGTC_2490 carminic acid 95.39 µM -1.45469239603794 0.0745916027146838 no 3156 0.0728772193171394 4446 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2312 7706453 155.7 µM -1.46209267048265 0.0735755897980386 no 3157 0.071857908495049 4475 976098
SGTC_99 0109-0120 622.8 µM -1.46595623080413 0.0730493678648958 no 3158 0.0713301056669634 4477 759414
SGTC_121 0557-0495 61.343 µM -1.46912277595793 0.072620232024842 no 3159 0.0708997455809886 4514 3104427
SGTC_2357 9067248 200 µM -1.47014410712716 0.0724822320004723 no 3160 0.0707613643507612 4428 9150235
SGTC_181 1447-1644 8.07 µM -1.47314199520124 0.0720783241562129 no 3161 0.0703563758746131 4427 534600
SGTC_808 0711-0032 135 µM -1.47352260365345 0.0720271681564332 no 3162 0.0703050867566701 4448 4252555
SGTC_3210 9128157 49.47 µM -1.47593858612262 0.0717030949027567 no 3163 0.0699801898597791 4432 17590849
SGTC_2909 7941780 10.49 µM -1.47658810262365 0.0716161616033148 no 3164 0.0698930414087598 4437 1243215
SGTC_2217 6934799 96.0675 µM -1.48172744637599 0.0709311447863994 no 3165 0.0692064155180765 4458 675606
SGTC_193 1273-0060 1.558 µM -1.49163774395406 0.0696244377261011 no 3166 0.0678970689289288 4335 2847393 YHR072W ERG7
SGTC_3342 9147791 14.508 µM -1.49789382547452 0.0688091442128884 no 3167 0.0670804190836669 4452 1838168
SGTC_2366 9070441 60.58 µM -1.49850824551889 0.0687294715170815 no 3168 0.0670006259768016 4471 6837235
SGTC_1684 st024538 14.6195 µM -1.50087365868861 0.0684234090856723 no 3169 0.0666941212216742 4459 6732859
SGTC_2959 9079155 11 µM -1.50185736054989 0.0682964372408298 no 3170 0.0665669753293935 4499 16189457
SGTC_1782 st039423 80.636 µM -1.50254022595811 0.0682084029964499 no 3171 0.0664788236760725 4504 2068169
SGTC_1928 4'-methoxychalcone 40.3 µM -1.50404328823722 0.0680149384680338 no 3172 0.0662851105452996 4507 641818
SGTC_1503 4585-0012 61.3 µM -1.50775703985408 0.0675387449105986 no 3173 0.0658083604685679 4509 2922052
SGTC_2958 9077254 16.72 µM -1.50909593938865 0.0673676985705112 no 3174 0.0656371335583101 4515 16457351
SGTC_1875 nocodazole 6 µM -1.52313353345065 0.0655944763994099 no 3175 0.0638626503988837 4526 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_379 3970-0972 5.9 µM -1.52403468274356 0.0654818917249573 no 3176 0.0637500237692854 4506 2898042 YBL034C STU1
SGTC_1215 3852-0577 11.2 µM -1.52921140010165 0.0648380417660636 no 3177 0.0631060226803917 4533 2884876
SGTC_663 1486-0733 13.9 µM -1.53184543030417 0.0645123286905971 no 3178 0.0627802911262222 4528 722445 YPR165W RHO1
SGTC_34 0469-0683 81.75 µM -1.53262455676125 0.0644162291960756 no 3179 0.0626841936716395 4489 3690923
SGTC_2277 7947813 106.88 µM -1.53417243411759 0.064225639986736 no 3180 0.0624936186459577 4526 1246798
SGTC_1416 3966-0321 25.3 µM -1.53622702035143 0.0639733373631553 no 3181 0.0622413556028937 4556 582530 YLR208W SEC13
SGTC_1976 st070609 63.5 µM -1.5374504364594 0.0638234687062761 no 3182 0.0620915217209894 4462 682556
SGTC_2294 7971431 200 µM -1.53988881954756 0.0635255810976237 no 3183 0.0617937282715957 4510 5741572
SGTC_402 epigallocatechin gallate 10 µM -1.54046568660905 0.0634552660476613 no 3184 0.0617234403238137 4482 65064 An antioxidant.
SGTC_3341 9147222 25.867 µM -1.5444053078507 0.062976679005851 no 3185 0.0612450874962405 4525 1939759
SGTC_2803 7707263 71.43 µM -1.54964846281722 0.0623441049295131 no 3186 0.0606129571229433 4484 2199229
SGTC_3330 9141424 71.43 µM -1.55126025176142 0.0621506454639508 no 3187 0.0604196641082716 4538 27261020
SGTC_3193 9111931 49.47 µM -1.55612836310025 0.0615691794073983 no 3188 0.0598387858550483 4517 17087244
SGTC_376 3970-0862 59.1 µM -1.56045157916967 0.0610563672491832 no 3189 0.0593266020131603 4540 3135186
SGTC_179 1273-0063 6.77 µM -1.56476229988492 0.0605483674362831 no 3190 0.0588193272744423 4505 3108139
SGTC_492 tmb-8 126 µM -1.56754577252817 0.0602221081254487 no 3191 0.0584935880023123 4559 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1645 Cervolide 78 µM -1.57370784156277 0.0595047296308247 no 3192 0.0577775040682529 4554 23173 A fragrance.
SGTC_1804 st050076 49.1 µM -1.57796246493069 0.0590133342480334 no 3193 0.0572871165695095 4566 3895976
SGTC_1365 1672-3266 55.4 µM -1.5809044537161 0.058675409745717 no 3194 0.0569499429231132 4558 6415873
SGTC_1453 4237-0541 195 µM -1.583524785125 0.058375712262278 no 3195 0.0566509510398782 4537 739892
SGTC_2700 st077718 96.8 µM -1.58570220261522 0.0581275882917604 no 3196 0.0564034396454987 4506 904970
SGTC_1811 st050069 61.5 µM -1.58582535933399 0.0581135789725716 no 3197 0.0563894656831756 4543 3877702
SGTC_334 1502-1024 68.5 µM -1.59014438621438 0.0576239570414659 no 3198 0.0559011314535725 4547 3296216
SGTC_1167 k781-0610 148 µM -1.60650354462553 0.0557987783897205 no 3199 0.0540816583768966 4582 4525169
SGTC_2434 5670830 169.91 µM -1.6074841134589 0.0556908429246765 no 3200 0.0539741058024757 4555 1549830
SGTC_1677 st019204 53.9 µM -1.61397164551716 0.0549808779678235 no 3201 0.0532667883482201 4549 3945625
SGTC_812 4251-0442 148 µM -1.61540725015168 0.0548247427401448 no 3202 0.0531112656040181 4573 5723007
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.61608033848385 0.0547516589658764 no 3203 0.0530384722933059 4556 7104
SGTC_2036 5160441 105 µM -1.61991783765954 0.0543364543955342 no 3204 0.0526249637760782 4526 134534 YIL048W NEO1
SGTC_2282 7944268 200 µM -1.62017826205802 0.054308367853132 no 3205 0.0525969947906897 4533 2970414
SGTC_1218 1348-1416 30.7 µM -1.62038501995991 0.0542860773757608 no 3206 0.0525747978666103 4534 6787668
SGTC_1840 st055363 71 µM -1.62177022173215 0.0541369260366411 no 3207 0.0524262783517988 4581 676033
SGTC_535 2293-4129 48.2 µM -1.63230568133109 0.0530131109872836 no 3208 0.0513075535024329 4546 396118 YIL048W NEO1
SGTC_198 3454-2873 16.191 µM -1.6346351087475 0.052767146499979 no 3209 0.0510627815794006 4561 710957
SGTC_559 1550-0661 158 µM -1.63868291078154 0.0523418931366642 no 3210 0.050639657460705 4606 5830875
SGTC_2240 6690706 185.951 µM -1.6459481228837 0.0515854548878035 no 3211 0.0498872200322049 4461 805876
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.64615141249117 0.0515644144862606 no 3212 0.0498662948536162 4568 23847180
SGTC_3240 9133527 49.47 µM -1.64784533781178 0.051389359034255 no 3213 0.04969220638031 4555 17617455
SGTC_3027 9089541 49.47 µM -1.64810241606119 0.0513628331387196 no 3214 0.0496658283089953 4558 9943819
SGTC_1266 0828-0227 32.9 µM -1.65185594165849 0.0509767752371563 no 3215 0.0492819607213945 4548 3913820
SGTC_3311 9131146 2.8755 µM -1.6521756807921 0.0509439964464762 no 3216 0.0492493712650924 4529 4900406 YPR165W RHO1
SGTC_432 NS 1619 61.3 µM -1.65612552397952 0.0505404515712461 no 3217 0.0488482007163561 4532 4552 A K+/calcium channel activator.
SGTC_1510 1123-0200 71.5 µM -1.66007091925971 0.050139907455454 no 3218 0.0484500931758262 4569 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2985 9022375 71.43 µM -1.66054036907167 0.0500924169508798 no 3219 0.0484028968775558 4578 4939335
SGTC_3185 9108267 49.47 µM -1.66252401507661 0.0498921430579804 no 3220 0.0482038761476239 4562 4910486
SGTC_2879 9041815 71.43 µM -1.66838519947162 0.0493041125622927 no 3221 0.0476196422229336 4618 4942971
SGTC_288 1315-0019 35.1 µM -1.66951658737748 0.049191244416048 no 3222 0.0475075229307781 4609 6811474
SGTC_1465 k213-0056 144 µM -1.67638386366411 0.0485105802583201 no 3223 0.0468315137786839 4500 24048857 YMR208W ERG12
SGTC_3045 9092950 49.47 µM -1.6826558322476 0.0478955210975661 no 3224 0.046220868309245 4557 44120432
SGTC_827 3253-0474 693 µM -1.68416121564025 0.0477488289294921 no 3225 0.0460752582238192 4591 5402065
SGTC_1581 himbacine 57.9 µM -1.68711355119613 0.0474621831927038 no 3226 0.0457907599200771 4590 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_381 3461-2219 42.7 µM -1.69466255697243 0.046735508229965 no 3227 0.0450697262583397 4569 2883159
SGTC_1723 st034307 2.5525 µM -1.69576612345369 0.046630029582936 no 3228 0.044965090201703 4577 867466
SGTC_269 exalamide 29 µM -1.69776470210713 0.0464394921611974 no 3229 0.0447760902272048 4575 3316 A derivative of salicylamide.
SGTC_2175 5807670 165.306 µM -1.69789078973557 0.0464274924012256 no 3230 0.044764187958021 4559 241186
SGTC_939 1165-0479 45.3 µM -1.69853294826653 0.0463664167854076 no 3231 0.0447036097678988 4561 1377347
SGTC_2817 7995342 71.43 µM -1.7024801649196 0.0459924130287471 no 3232 0.0443326968230414 4565 18879975
SGTC_967 1306-0166 352 µM -1.70584281191725 0.0456757132649552 no 3233 0.0440186748647423 4587 4437607
SGTC_2093 5331342 194.4 µM -1.7059364553048 0.045666918925404 no 3234 0.0440099556815346 4615 33839
SGTC_1682 st012968 530 nM -1.70655778624671 0.0456086022916461 no 3235 0.0439521385146399 4563 24207270
SGTC_820 1582-0060 59.9 µM -1.71119975843442 0.045174810200584 no 3236 0.0435221216375529 4622 3848840
SGTC_777 1315-0167 517 µM -1.71392044454693 0.0449221092282099 no 3237 0.0432716688607363 4615 4221767
SGTC_1091 telmisartan 47.6 µM -1.71678518944215 0.0446572590728679 no 3238 0.0430092140097493 4620 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1180 1193-0155 285 µM -1.72159030787279 0.0442158434887855 no 3239 0.04257188007366 4643 2921347
SGTC_2986 9022445 71.43 µM -1.73286373378818 0.0431940250396258 no 3240 0.0415599457758163 4577 6459286
SGTC_1202 1988-0068 29.6 µM -1.73751854878536 0.0427777163356716 no 3241 0.0411478414316042 4577 2850480
SGTC_3059 1327-0034 3 µM -1.74332578329152 0.0422628931734193 no 3242 0.040638362037814 4458 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2794 7785382 27.27 µM -1.75879999814881 0.0409155160594418 no 3243 0.0393057425581413 4591 2205081
SGTC_3145 9085516 49.47 µM -1.75970597434093 0.0408377228783994 no 3244 0.0392288361632709 4590 25236195
SGTC_1007 4101-0031 70 µM -1.76583595466382 0.0403145094250056 no 3245 0.0387116872592372 4608 1146276
SGTC_1821 st053465 65.6 µM -1.76619695044429 0.0402838678068393 no 3246 0.0386814062519808 4637 675086
SGTC_1996 st072960 66.8 µM -1.77396178137503 0.0396293493444346 no 3247 0.0380347361297574 4636 1719405
SGTC_1452 4194-0072 190 µM -1.78337686936942 0.0388473545594894 no 3248 0.0372624879606416 4654 1343545
SGTC_3279 9140807 49.47 µM -1.78851519735615 0.038425906820218 no 3249 0.0368464629959866 4666 45595718
SGTC_1733 st037357 54.9 µM -1.79135767286446 0.0381943716229902 no 3250 0.0366179583375389 4546 1272339 YGL099W LSG1
SGTC_952 1185-0122 232 µM -1.81094432930645 0.0366296918807291 no 3251 0.0350747348317492 4584 678600
SGTC_1516 st013856 110 µM -1.82496046433064 0.0355425153077818 no 3252 0.034003497845299 4646 5281404 A mutagen and neurotoxin.
SGTC_173 1273-0061 2.693 µM -1.82640329715559 0.0354321180184555 no 3253 0.0338947677953956 4582 2847414 YPL266W DIM1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.82900882913577 0.0352334700779744 no 3254 0.0336991427974886 4646 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2141 5621638 7.665 µM -1.83114710863539 0.0350711292188588 no 3255 0.0335392943695662 4643 2856238
SGTC_885 0865-0106 16.8 µM -1.83211266532332 0.0349980243720868 no 3256 0.0334673183968876 4606 2793380
SGTC_2207 7258803 200 µM -1.83905299148129 0.0344762265787812 no 3257 0.0329536961272288 4664 3666799
SGTC_397 arbidol 50 µM -1.8429686862658 0.0341846624991151 no 3258 0.032666791285517 4649 131410 A RNA synthesis inhibitor.
SGTC_2605 digitonin 300 nM -1.84662855991469 0.0339139826235478 no 3259 0.0324004960152201 4619 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_152 4469-0003 551.229 µM -1.86523846048286 0.0325647576707201 no 3260 0.031073993393224 4635 697280
SGTC_2865 9030313 51.95 µM -1.86543811012396 0.0325505266110343 no 3261 0.0310600098375095 4623 42562754
SGTC_101 0490-5701 117.494 µM -1.86580093918341 0.0325246772274127 no 3262 0.0310346104467531 4540 4661669
SGTC_147 4466-0538 29.23 µM -1.86787860703885 0.0323769818241187 no 3263 0.0308894967044135 4644 6742687 YHR072W ERG7
SGTC_2216 7189485 200 µM -1.87034157993265 0.0322026135172784 no 3264 0.030718199477112 4684 731273
SGTC_1567 st069303 68.4 µM -1.87140616163585 0.0321274858278959 no 3265 0.0306444027561871 4639 5581319
SGTC_2060 5238662 140 µM -1.87621534886969 0.0317899018680629 no 3266 0.0303128576431143 4621 790130
SGTC_2145 5634607 200 µM -1.88301264810651 0.031317764074396 no 3267 0.0298493269548749 4663 308662
SGTC_338 4055-0136 114 µM -1.88466307117722 0.0312040054344438 no 3268 0.0297376705708131 4645 2900563
SGTC_729 4092-0585 94.1 µM -1.89574963499709 0.0304486711103668 no 3269 0.0289965792912401 4671 2169061
SGTC_1052 3253-3998 198 µM -1.90049393648057 0.0301300992107547 no 3270 0.0286841649760211 4626 5450317
SGTC_732 3970-1727 52.7 µM -1.90070881810046 0.0301157359280689 no 3271 0.0286700814472052 4691 1275699
SGTC_1992 st073643 23.3 µM -1.90263660458492 0.0299871310740592 no 3272 0.028543989668292 4662 3161292
SGTC_2782 7736369 71.43 µM -1.92020469586774 0.0288360008342796 no 3273 0.0274160243568818 4632 2950836 YOL077C BRX1
SGTC_2440 5628896 157.78 µM -1.92231152247617 0.0287004534539592 no 3274 0.027283285499357 4631 5522048
SGTC_2826 7992541 19.48 µM -1.92249838184406 0.028688457062865 no 3275 0.0272715385055549 4645 2985066
SGTC_1364 1653-0028 37.6 µM -1.92254175995606 0.0286856727799399 no 3276 0.0272688121255121 4678 5718652
SGTC_1186 1319-0216 26 µM -1.93124516346631 0.0281315610711079 no 3277 0.0267263706181194 4692 4565136
SGTC_2295 7971645 200 µM -1.93400035439885 0.0279580169523985 no 3278 0.0265565421373824 4685 2978226 YKL099C UTP11
SGTC_1697 st025554 27.742 µM -1.9508894235884 0.0269135888402084 no 3279 0.0255351005299801 4697 1269519
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.95373064930283 0.0267411274400383 no 3280 0.025366539816733 4647 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1888 azatryptophan 97.5 µM -1.95920777444018 0.0264112718737318 no 3281 0.0250442295170327 4686 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1881 5652484 16 µM -1.95962399993693 0.0263863446528651 no 3282 0.0250198770453535 4650 2255129
SGTC_3343 9148379 18.9835 µM -1.96019065464669 0.0263524400253439 no 3283 0.0249867551922303 4690 1955036
SGTC_1086 cerivastatin 2.18 µM -1.96074772261575 0.0263191445030986 no 3284 0.0249542295411091 4683 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2607 solasodine 47.35 µM -1.97055528381356 0.0257386900058864 no 3285 0.0243873828130905 4615 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2450 5739737 12.93 µM -1.97442307505322 0.0255127420111671 no 3286 0.0241668281937125 4678 2262825
SGTC_1320 1313-0481 95.3 µM -1.98978856882726 0.0246314644344861 no 3287 0.0233071155972796 4646 6813365 YLR208W SEC13
SGTC_2975 9084847 53.72 µM -2.00794527115526 0.0236231642053167 no 3288 0.0223245538631027 4655 27211724
SGTC_209 4077-0173 175.592 µM -2.01574488837028 0.0232008088731087 no 3289 0.0219133295599241 4670 15993494
SGTC_3289 9119912 71.43 µM -2.0182158937432 0.0230683352318106 no 3290 0.0217843907849871 4671 17014829
SGTC_79 0052-0007 94.094 µM -2.01916096732609 0.0230178373500358 no 3291 0.0217352458946105 4671 2801472
SGTC_2041 5107442 45.335 µM -2.03005486860632 0.0224424378172829 no 3292 0.0211754811613291 4707 793005
SGTC_477 mead ethanolamide 10 µM -2.03606668842602 0.0221301297585662 no 3293 0.0208718295888061 4720 16061185
SGTC_2880 9042983 58.44 µM -2.0407852755128 0.0218875803746588 no 3294 0.020636087387727 4638 6464714
SGTC_571 k831-0106 44.2 µM -2.04269989987038 0.0217898052344434 no 3295 0.0205410773754874 4617 4783639
SGTC_374 0880-0231 82.3 µM -2.04320096213046 0.0217642782147388 no 3296 0.0205162742757891 4584 6833587
SGTC_2356 9061756 188.97 µM -2.05804399680349 0.0210194663589868 no 3297 0.019792955089165 4714 20104043
SGTC_2076 5212012 200 µM -2.06240353909985 0.0208048492764743 no 3298 0.0195846663258595 4692 604802
SGTC_360 0957-0399 1.01 µM -2.07502603458057 0.0201938885190437 no 3299 0.0189920609773976 4696 6752301 YPR165W RHO1
SGTC_3039 9090270 49.47 µM -2.07620073678563 0.0201378117590094 no 3300 0.0189376945866634 4683 17173750
SGTC_1012 4112-3522 18 µM -2.08990868165227 0.0194931393204007 no 3301 0.0183130017858766 4696 3112398
SGTC_487 nimodipine 119 µM -2.09044684716894 0.0194681916714821 no 3302 0.0182888391823607 4725 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1728 st035614 33.7865 µM -2.09074554642941 0.0194543566278774 no 3303 0.0182754398819199 4662 15945546
SGTC_705 1124-0212 310 µM -2.10387754969968 0.0188543148034725 no 3304 0.0176945649034253 4696 9554485
SGTC_2406 ethylparaben 405.7 µM -2.1452547548968 0.0170655977568611 no 3305 0.0159662419409295 4667 8434 A possible steroid mimic.
SGTC_49 0717-0965 32.132 µM -2.17675374550967 0.015803038518911 no 3306 0.0147494729353586 4736 5889349 YGL099W LSG1
SGTC_2413 inermin 26.06 µM -2.17780916599334 0.0157621599757723 no 3307 0.0147101236072152 4710 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_41 0478-0632 82.643 µM -2.18506532918922 0.0154835621619336 no 3308 0.0144420284550873 4690 3750424
SGTC_491 tetrandrine 80.3 µM -2.19000578807383 0.0152963028997081 no 3309 0.0142619085256248 4733 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_226 1,3-diallylurea 8.28947 mM -2.21827118485055 0.0142619326507695 no 3310 0.0132681738285664 4720 74537 YKL182W FAS1
SGTC_2870 9038528 12.99 µM -2.25264802374172 0.0130856035639333 no 3311 0.0121406752840032 4723 6463316
SGTC_163 TUB2.036 7.546 µM -2.25653201678047 0.0129581253161297 no 3312 0.0120186662622621 4678 15992207 YJR013W GPI14
SGTC_1240 0356-0016 42.1 µM -2.26848266281535 0.0125726002228247 no 3313 0.0116499022658435 4705 4305613
SGTC_479 n-linoleoylglycine 10 µM -2.28007823547094 0.0122080608458843 no 3314 0.0113015244050527 4748 6433346 An anti-infammatory.
SGTC_1553 gossypol 38.6 µM -2.3057448914191 0.0114335926512697 no 3315 0.0105624455663442 4727 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2144 5628481 200 µM -2.31164961361771 0.0112615851072931 no 3316 0.0103985000856478 4746 2818399
SGTC_3074 9116018 49.47 µM -2.32323531645444 0.0109306146582183 no 3317 0.0100832572578465 4746 17027303
SGTC_37 0566-0070 1.56 µM -2.33481105823691 0.0106084143203409 no 3318 0.0097766466307702 4708 1626686
SGTC_196 k015-0023 18.111 µM -2.3692758134251 0.00969760999874816 no 3319 0.00891147831105389 4740 5211998
SGTC_25 0118-0223 35.662 µM -2.37666720478556 0.00951142465233464 no 3320 0.00873492084865754 4739 5333628
SGTC_940 3232-1287 54.8 µM -2.37774787653047 0.0094844666388762 no 3321 0.00870936561947876 4738 1585493 YIL048W NEO1
SGTC_2468 5987765 72.9 µM -2.37798580154993 0.00947854043651862 no 3322 0.00870374809150172 4759 26772094
SGTC_2322 7413319 38.22 µM -2.43198469809749 0.00821453652750435 no 3323 0.00750817084709009 4691 1840400
SGTC_111 0083-0039 52.457 µM -2.46641699484151 0.00748813221216224 no 3324 0.00682361773542192 4757 759313
SGTC_2913 7966556 36.57 µM -2.492772171288 0.00697097491664107 no 3325 0.00633750731786304 4683 2976516
SGTC_2126 5251174 33.877 µM -2.49402623645842 0.00694717250761082 no 3326 0.00631516041574867 4730 790722
SGTC_2721 ifenprodil 61.44 µM -2.50504369428144 0.00674112438428382 no 3327 0.00612181334759437 4752 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3259 9138485 49.47 µM -2.53079172785283 0.00628050771607645 no 3328 0.00569027011339428 4739 17646153
SGTC_3056 9094900 49.47 µM -2.54528033050059 0.00603375938601057 no 3329 0.00545950203555612 4759 25236784
SGTC_325 2810-4341 181 µM -2.54664010415251 0.00601104878743208 no 3330 0.00543827705730553 4773 774970
SGTC_1699 st031318 29.054 µM -2.5544899290773 0.00588141835319488 no 3331 0.00531717530048015 4793 5340658
SGTC_2924 9010168 62.78 µM -2.65328447359475 0.00444956158133809 no 3332 0.00398563294125168 4752 2993929
SGTC_3126 9127922 49.47 µM -2.65499087815845 0.00442783864579937 no 3333 0.00396552765776619 4726 45595682
SGTC_48 0382-0018 55 µM -2.66761281764278 0.00427007867396958 no 3334 0.00381961183673689 4772 762596
SGTC_1245 0418-0076 17.2 µM -2.67966872116778 0.00412410582093111 no 3335 0.00368475267911223 4771 6790114
SGTC_2768 sulfasalazine 50.2 µM -2.70367522237196 0.00384666491767612 no 3336 0.00342886403253448 4756 5384001 An antioxidant and salicylic acid derivative.
SGTC_3223 9129970 49.47 µM -2.73058381393435 0.00355566540296724 no 3337 0.00316111274634891 4784 17248386
SGTC_133 0724-0033 378.92 µM -2.73723541928565 0.00348684988333377 no 3338 0.00309789683591573 4752 280309
SGTC_1734 st037168 69.4 µM -2.80283872227368 0.00286955231700806 no 3339 0.00253274965519044 4768 708907
SGTC_110 0850-0284 111.64 µM -2.84065106175493 0.00256030576493465 no 3340 0.00225107721946878 4776 3906265
SGTC_216 k038-0035 28.382 µM -2.85730445439618 0.00243392364586763 no 3341 0.00213627901929081 4779 4444231 YPR107C YTH1
SGTC_2365 9042475 200 µM -2.86763428301203 0.00235839486861175 no 3342 0.00206776632968575 4779 6464479
SGTC_2267 7931562 200 µM -2.91120502454773 0.00206262003644697 no 3343 0.00180018841344388 4769 934880
SGTC_1206 3978-0017 132 µM -2.91477781926996 0.00203992708584124 no 3344 0.00177970922157374 4773 3873677
SGTC_1701 st028638 40.4 µM -2.99345986144564 0.00159425527316562 no 3345 0.00137916894135402 4794 3490878
SGTC_2456 5770359 74.46 µM -3.2781689384111 0.000623950890376815 yes 3346 0.000522414219404941 4799 3118787
SGTC_2971 9092186 9.93 µM -3.3395377974087 0.000504899439821441 yes 3347 0.000419589651390751 4777 25236400
SGTC_2852 9023854 51.95 µM -3.36285398050708 0.00046546420245837 yes 3348 0.000385705777713413 4792 19798528
SGTC_2911 7942208 15.64 µM -3.65433929397731 0.000161580709734768 yes 3349 0.000128922552966149 4803 1243384
SGTC_2567 aureobasidin a 60 nM -3.67759734507606 0.000148009089014652 yes 3350 0.000117720617323582 4792 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_194 1486-1323 56.904 µM -3.73049220345282 0.000121016163873229 yes 3351 9.55530287508192e-05 4807 5178754
SGTC_2856 9022925 19.48 µM -4.27800919763975 1.29624330549566e-05 yes 3352 9.42861156303957e-06 4797 4944862
SGTC_2464 5717415 7.67 µM -4.73604380761053 1.61964484936093e-06 yes 3353 1.0896525007728e-06 4807 5285744
SGTC_893 0958-0369 48.9 µM -5.12519411240207 2.37641938285141e-07 yes 3354 1.48615680039824e-07 4791 6819948
SGTC_2462 5162487 171.77 µM -5.17446451500686 1.8452217182077e-07 yes 3355 1.14282771184658e-07 4809 2259986
SGTC_2455 5377712 9.75 µM -7.47553354236025 1.09108831461134e-13 yes 3356 3.84456211635382e-14 4810 2243908