SGTCid condition conc unit PDR18|YNR070W.score PDR18|YNR070W.strain.pval PDR18|YNR070W.strain.significant PDR18|YNR070W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1360 1598-0022 39.8 µM 6.50589593483277 5.96921964612135e-12 yes 1 3.8615839660223e-11 6 761525 SGTC_1248 0469-0687 58.6 µM 5.24994905000638 2.11669012968959e-08 yes 2 7.60706425354217e-08 7 4017482 SGTC_2198 6589944 200 µM 4.71659958647102 4.13854031256678e-07 yes 3 1.19909504052701e-06 11 5290268 SGTC_1837 st055472 66.5 µM 4.62790117424323 6.59399084506545e-07 yes 4 1.84695100528715e-06 12 676091 SGTC_1500 4488-1866 171 µM 4.61596093492765 7.01635085764419e-07 yes 5 1.95640275331648e-06 7 2900003 SGTC_1834 st055981 52.8 µM 4.40352070346048 2.06603253753672e-06 yes 6 5.32540571899162e-06 25 471719 YDL150W RPC53 SGTC_2055 5235184 200 µM 3.93752278883907 1.87605538323248e-05 yes 7 4.11635577217812e-05 31 2836034 SGTC_2638 epoxomicin 18 µM 3.87609057507057 2.46792744089393e-05 yes 8 5.30740922022814e-05 38 9915668 A protesome inhibitor. SGTC_1355 1499-0035 1.68 µM 3.79563452170779 3.51367946851039e-05 yes 9 7.36331576149099e-05 20 1548538 SGTC_1871 st057448 67.3 µM 3.68821747573885 5.57356014633931e-05 yes 10 0.000112915297454288 32 691747 SGTC_2382 9035899 200 µM 3.67242304429117 5.95887163306413e-05 yes 11 0.000120130757588519 22 6462679 SGTC_2262 9014885 67.46 µM 3.65993613945276 6.28112996748096e-05 yes 12 0.000126139056417811 6 6457424 SGTC_1305 1181-0477 144 µM 3.59200882530779 8.34182367069547e-05 yes 13 0.00016406936721527 21 6252086 SGTC_2312 7706453 155.7 µM 3.48552240840034 0.000128923694487537 yes 14 0.000245588541108885 41 976098 SGTC_1403 3909-7815 62.9 µM 3.46117454959476 0.00014218751475887 yes 15 0.000268911986592937 28 6615483 SGTC_808 0711-0032 135 µM 3.44968823442407 0.000148879240867161 yes 16 0.000280617151324119 29 4252555 SGTC_792 4534-1957 155 µM 3.44058759230024 0.000154389347245998 yes 17 0.000290226261317758 59 1717904 SGTC_1492 4158-0558 28.5 µM 3.43752168007106 0.000156288245431595 yes 18 0.000293531860471267 25 3967268 SGTC_624 k048-0052 28 µM 3.37372900663649 0.00020111891307527 yes 19 0.000370786668163548 30 6835531 SGTC_1014 4130-3005 69.3 µM 3.31976511053272 0.000248146649273377 yes 20 0.000450466083538581 42 743608 SGTC_1900 st060200 72.8 µM 3.2851836965535 0.000283475452646292 yes 21 0.000509579508564425 44 688945 SGTC_793 0488-0545 106 µM 3.20666675532062 0.000381786675741299 yes 22 0.000671412261524066 34 292548 SGTC_3219 9131112 49.47 µM 3.18823795468123 0.000409052690397833 yes 23 0.000715713435404903 60 17612988 YMR079W SEC14 SGTC_1363 1636-0063 10.4 µM 3.18015569508026 0.000421571470705955 yes 24 0.000735979714925547 62 6072185 SGTC_2451 5856223 45.7 µM 3.07886827859763 0.000611676788561093 yes 25 0.00103894265569366 50 2179896 SGTC_1755 st041960 45.185 µM 3.06005329749278 0.000654722478984423 yes 26 0.00110648803210481 54 2257073 SGTC_938 3126-1755 342 µM 2.99024868640023 0.000840017597469371 yes 27 0.00139375200880067 43 1777771 SGTC_3151 9099821 49.47 µM 2.95313017509345 0.00095714459432771 yes 28 0.00157284640037745 63 17174189 SGTC_2707 st078556 66.6 µM 2.90954651949514 0.00111372347563958 no 29 0.00180976758067783 46 17250899 SGTC_804 1595-0054 20.9 µM 2.90335744157745 0.00113776997738479 no 30 0.00184592503696076 94 761523 Stimulates phospholipase C. SGTC_2363 9053361 176 µM 2.89683317681179 0.00116363298314706 no 31 0.00188475071197735 84 6469797 YMR079W SEC14 SGTC_19 0279-0214 38.434 µM 2.88947665768796 0.00119344022211349 no 32 0.00192941827386914 126 3566274 YBR002C RER2 SGTC_3300 9124615 50.48 µM 2.8847644365839 0.00121289882569749 no 33 0.00195853318271969 77 24824903 SGTC_1371 2421-0008 32.7 µM 2.83030296270592 0.00145984243612823 no 34 0.00232519726745149 114 2827552 SGTC_403 arphamenine a 50 µM 2.82453826637569 0.00148850328448662 no 35 0.00236743970066777 74 5487158 An arginine aminopeptidase inhibitor. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.81649765363922 0.00152933725118142 no 36 0.00242751987997285 103 23665772 A membrane-active detergent. SGTC_2611 pyromycin 23.93 µM 2.74607556855986 0.00193308568359061 no 37 0.00301564347063349 106 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2380 9035439 200 µM 2.74074716640778 0.00196726428211231 no 38 0.00306498286863983 105 6462575 SGTC_825 1988-2224 89.6 µM 2.72280441170961 0.00208643059996586 no 39 0.00323651838685041 110 1180859 SGTC_3218 9131285 49.47 µM 2.70842885078357 0.00218658985957911 no 40 0.00338013026886202 134 17156417 SGTC_865 0488-0499 301 µM 2.70349726602171 0.00222194125560713 no 41 0.00343070062233395 69 9634651 SGTC_2949 9072542 2.23 µM 2.69248339334121 0.0023027697309051 no 42 0.00354610337466171 126 16457352 SGTC_829 1635-0120 117 µM 2.64478628121562 0.00268442550386297 no 43 0.00408712637629498 124 285054 SGTC_2178 5812956 200 µM 2.63558125873928 0.00276434433536633 no 44 0.00419966561075598 82 5403383 SGTC_1829 berberine 14.4 µM 2.61692396108562 0.00293294850334747 no 45 0.00443630519795685 84 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1134 3477-0009 42.5 µM 2.61321598291268 0.00296754120530688 no 46 0.00448472996373876 145 3973534 SGTC_2916 7875993 68.79 µM 2.61268854761208 0.00297249154521878 no 47 0.00449165627903852 120 1299250 SGTC_1832 st054113 55 µM 2.6055923937284 0.00303982118145595 no 48 0.00458577668375114 58 1251267 SGTC_1245 0418-0076 17.2 µM 2.59932194845793 0.00310045624989461 no 49 0.00467040609928953 106 6790114 SGTC_1702 st027038 51 µM 2.58218430197736 0.0032717710794957 no 50 0.00490885698480296 86 5521182 SGTC_2140 5586273 200 µM 2.55098215607199 0.00360567257749227 no 51 0.00537099127176549 67 854421 SGTC_668 1682-0499 62.6 µM 2.52747155370573 0.00387713801889421 no 52 0.0057443565276647 121 682214 SGTC_526 4469-0568 170 µM 2.50164954506284 0.00419627132876086 no 53 0.00618081115354922 127 2901964 SGTC_963 1269-2853 151 µM 2.49715533625003 0.00425415551334274 no 54 0.00625970510144124 119 3668223 SGTC_2237 6667747 47.222 µM 2.46623609745302 0.00467211333227011 no 55 0.00682706509332938 90 729940 YDL015C TSC13 SGTC_1793 st048256 72.231 µM 2.44446990522741 0.00498793386687178 no 56 0.00725325915250161 62 672022 SGTC_3044 9093193 49.47 µM 2.41381226686749 0.00546500391923107 no 57 0.00789329698447055 154 25236277 SGTC_2162 5663267 200 µM 2.41103499643427 0.00551016270699288 no 58 0.00795366098999747 92 6456493 SGTC_518 1021-0119 62.6 µM 2.41098851213871 0.00551092136060615 no 59 0.00795467477124858 162 1097762 SGTC_2625 euphol 100 µM 2.39989388087415 0.00569466912238805 no 60 0.00819991271522507 157 6708538 A triterpene alcohol. SGTC_3111 9122088 49.47 µM 2.39866764275785 0.00571530802837985 no 61 0.00822742118633334 60 16876704 SGTC_830 4076-0286 57.8 µM 2.38532957185108 0.00594412769173463 no 62 0.00853191339421906 262 6866659 SGTC_1239 0337-0584 35.4 µM 2.37881571526814 0.00605879965550457 no 63 0.00868417827787266 200 914301 YML130C ERO1 SGTC_2831 7999036 19.48 µM 2.37822498374981 0.00606929541167709 no 64 0.00869810408349453 192 2988270 SGTC_1388 3346-4487 254 µM 2.35874930481504 0.00642447315420176 no 65 0.00916831924163963 145 3345614 SGTC_619 1652-1634 108 µM 2.32959634384934 0.00699051660636077 no 66 0.00991374779021636 135 5400454 SGTC_3336 9143619 71.43 µM 2.32472793202138 0.00708921638362787 no 67 0.0100432563618217 135 45595730 SGTC_2063 5246145 200 µM 2.3146062626733 0.00729836190625656 no 68 0.0103172449154368 160 711240 SGTC_2484 5809818 12.04 µM 2.31038347369601 0.00738721393118046 no 69 0.0104334666095372 133 2870548 SGTC_3193 9111931 49.47 µM 2.3059828885124 0.007480820000349 no 70 0.0105557942432393 142 17087244 SGTC_890 0929-0006 47.2 µM 2.28506616841091 0.00794017679537474 no 71 0.0111544740962323 137 1378169 SGTC_2376 9072922 81.32 µM 2.27114943494711 0.00825938062884663 no 72 0.0115689666210731 187 17087968 SGTC_117 lucigenin 22.078 µM 2.26646071522138 0.00836943441037058 no 73 0.0117115949111747 247 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2636 apigenin dimethyl ether 100 µM 2.26207563832768 0.0084735240429464 no 74 0.011846365235109 203 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2586 curcumin 80 µM 2.25842222420554 0.00856111185285658 no 75 0.0119596742262133 234 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1472 k841-0093 193 µM 2.25833507689096 0.00856321080685772 no 76 0.0119623884997976 168 X1472 SGTC_2921 7974240 10.71 µM 2.25151637638787 0.00872884605737847 no 77 0.0121764254263729 200 2979074 YDR527W RBA50 SGTC_323 4013-0906 34.3 µM 2.24909527047779 0.00878833009469644 no 78 0.0122532176985399 114 2910086 SGTC_2745 rifampicin 24.3 µM 2.24100014417118 0.00898980688666965 no 79 0.0125130328347107 67 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1764 st044502 93.5 µM 2.23827652170108 0.00905849798222568 no 80 0.0126015141002363 170 8407 SGTC_2358 9037157 4 µM 2.22601063098031 0.00937357710111566 no 81 0.0130067346702645 180 2388925 SGTC_2715 st079500 56.4 µM 2.22292458723146 0.00945434331986032 no 82 0.0131104427649566 127 28246688 SGTC_667 1498-1044 59 µM 2.21989579060633 0.00953420238788891 no 83 0.0132129211627607 169 6739982 SGTC_770 0389-1121 67.2 µM 2.21933285179027 0.00954910998655207 no 84 0.0132320441015577 204 6753108 SGTC_1455 4262-0120 131 µM 2.20854402267654 0.00983878052635727 no 85 0.013603186281434 188 1529587 SGTC_1654 st012436 41.8 µM 2.20828707198392 0.00984577198493151 no 86 0.0136121339774572 132 4323132 SGTC_2041 5107442 45.335 µM 2.205368506785 0.00992548924434567 no 87 0.0137141230625462 195 793005 SGTC_1399 3562-5772 25 µM 2.19682785113418 0.0101620134053225 no 88 0.0140163715887754 126 23847490 SGTC_1145 3546-0597 10.2 µM 2.19286642545696 0.0102733800115763 no 89 0.0141585021729039 187 875334 SGTC_1672 st016598 6.51 µM 2.19069364306028 0.0103349137347689 no 90 0.0142369847138264 232 4665860 YNL267W PIK1 SGTC_1066 ketoconazole 628 nM 2.18938776415838 0.0103720509379689 no 91 0.0142843341151502 179 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_189 3970-0742 2.116 µM 2.18753696890561 0.0104248839875869 no 92 0.0143516737462029 109 2891807 SGTC_2825 7998094 58.44 µM 2.18597347002256 0.010469698458442 no 93 0.0144087731753725 176 2987815 SGTC_1710 st031758 61.5 µM 2.1837872214093 0.0105326442354327 no 94 0.0144889435095035 138 5394341 SGTC_2184 6075246 200 µM 2.17919092859163 0.0106660553954631 no 95 0.0146587437740261 160 2267320 SGTC_3355 9151058 44.0485 µM 2.17659809419938 0.0107419619064541 no 96 0.0147552837498889 156 17015728 SGTC_2712 st079126 47.7 µM 2.17283525036031 0.0108529574795028 no 97 0.0148963595951362 158 3152970 SGTC_2747 doxorubicin 7.63 µM 2.1701904026381 0.0109315708212694 no 98 0.0149962124192077 70 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2860 9025725 38.96 µM 2.16128965221592 0.011199780372539 no 99 0.0153364858779585 143 40546248 SGTC_443 clozapine 122 µM 2.15880346854403 0.011275712229536 no 100 0.0154327086448016 110 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.15775303828883 0.0113079282003433 no 101 0.0154735189346376 182 390807 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.14796686985073 0.0116119273612379 no 102 0.0158581937199566 221 442882 SGTC_3292 9120825 59.784 µM 2.13432114949341 0.0120476529304174 no 103 0.0164082505863707 173 24824900 SGTC_2799 7812892 81.82 µM 2.13041486157562 0.0121749670175806 no 104 0.01656868895726 199 20205235 SGTC_390 dec-rvkr-cmk 16.7 µM 2.12867935666885 0.0122319038387263 no 105 0.0166403989515335 210 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_406 estrone 100 µM 2.12482784872432 0.0123590853099792 no 106 0.0168004900831315 150 5870 A steroid. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.11320015384552 0.0127500191151842 no 107 0.0172918200738561 186 688662 SGTC_1889 st059080 5.18 µM 2.1081825372259 0.0129219930844301 no 108 0.0175076015985547 196 176925 Isolated from Daphnopsis sellowiana. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.09593046601142 0.0133503720890797 no 109 0.0180441798256921 203 94937 An inhibitor of serotonin biosynthesis. SGTC_551 k048-0028 34.9 µM 2.09113154687563 0.0135214731773748 no 110 0.0182581367415337 203 6836383 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.08584450542195 0.0137121661230922 no 111 0.0184963552514732 208 5393153 SGTC_1480 1070-0044 41.2 µM 2.08304221089471 0.0138141767966138 no 112 0.0186236880779219 200 3124987 SGTC_2084 5306078 60.6385 µM 2.0532699165917 0.0149390019045523 no 113 0.0200232034087476 199 679340 SGTC_911 3456-4043 236 µM 2.04524119182509 0.0152554918496698 no 114 0.0204155426521793 247 914281 SGTC_950 1165-0508 94.1 µM 2.03747664280336 0.0155670289304342 no 115 0.0208011501332126 213 6148369 SGTC_2193 5925765 200 µM 2.03575561225085 0.0156368163348742 no 116 0.0208874508391972 155 877370 SGTC_151 3013-0144 2.285 µM 2.03297782466373 0.0157500212802584 no 117 0.0210273817156661 217 906558 YHR107C CDC12 SGTC_2795 7780010 54.55 µM 2.03199177695976 0.0157903750229717 no 118 0.0210772442096021 212 953673 SGTC_684 1140-0066 328 µM 2.031843193228 0.0157964634543746 no 119 0.0210847664632941 251 6813534 SGTC_1573 oleylamine 1.06 µM 2.02936034697093 0.0158984999456324 no 120 0.0212108004189591 238 5356789 An amine of the fatty acid oleic acid. SGTC_811 0416-0114 265 µM 2.02858450557089 0.0159305000377281 no 121 0.0212503140265906 231 6612453 SGTC_692 k241-0027 77.8 µM 2.0284891577222 0.015934436530439 no 122 0.021255174386054 195 3600480 SGTC_782 0083-0095 30.5 µM 2.02524761140086 0.0160687626995708 no 123 0.0214209724984905 257 3591729 An indicator and reagent. SGTC_139 0099-0334 718.624 µM 2.02249779779666 0.0161834716585798 no 124 0.0215624754376213 258 97690 SGTC_1279 0874-0590 65.2 µM 2.01430076455335 0.0165295838812372 no 125 0.0219889828778906 223 3523074 SGTC_968 1309-0633 340 µM 1.97965372673927 0.0180633638445396 no 126 0.023871225731672 208 3761976 SGTC_1351 1496-0003 46.5 µM 1.97388416577063 0.0183302136271197 no 127 0.0241974578130568 216 3891978 SGTC_1644 st010134 20.9 µM 1.96988174268923 0.0185172976937396 no 128 0.0244259626616034 184 3818134 SGTC_2139 5578692 56.4705 µM 1.96414346626535 0.0187883552161144 no 129 0.02475672836492 195 650991 YMR113W FOL3 SGTC_2835 9006588 71.43 µM 1.95955700930961 0.019007425418983 no 130 0.025023795184029 258 2345538 SGTC_322 k048-0136 19.3 µM 1.95493908903624 0.0192301894043236 no 131 0.0252951300550751 196 6823282 SGTC_1030 k029-0042 36.7 µM 1.95350492458572 0.019299822122138 no 132 0.0253798971619223 273 6080581 SGTC_2467 5474540 200 µM 1.95234755699109 0.0193561716975852 no 133 0.0254484774099191 252 5413519 SGTC_1482 3346-2049 8.48 µM 1.95048146646387 0.0194473217665047 no 134 0.025559380135416 220 3826804 SGTC_2389 9091542 195.52 µM 1.95020475552047 0.019460868837444 no 135 0.0255758596123767 263 3626624 YOL127W RPL25 SGTC_296 1222-0039 74.9 µM 1.94972190996611 0.0194845269385129 no 136 0.0256046367095513 212 5984176 SGTC_3216 9129716 49.47 µM 1.94642332934193 0.0196468027012542 no 137 0.0258019547428494 217 8056934 SGTC_1827 berberine 7.24 µM 1.9293999699071 0.0205026341145271 no 138 0.0268406137266701 229 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1594 piperine 70.1 µM 1.92823711794371 0.0205622305009623 no 139 0.0269128196431478 264 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1744 st037937 38.9 µM 1.92259500970869 0.0208534771790943 no 140 0.027265465608761 237 1016152 SGTC_953 1188-0045 9.7 µM 1.9180922643577 0.0210884084479823 no 141 0.027549656584772 277 6144426 SGTC_1746 st038117 42 µM 1.91025739022998 0.021502532342691 no 142 0.028050040550538 271 2898218 SGTC_179 1273-0063 6.77 µM 1.90822040282499 0.0216113193658318 no 143 0.0281813678367111 218 3108139 SGTC_13 0199-0087 65 µM 1.8967583348013 0.0222321684809469 no 144 0.0289299203328407 227 4589825 SGTC_502 l-744,832 89.3 µM 1.89646108178904 0.0222484674992174 no 145 0.0289495507636169 250 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_211 3455-0679 143.504 µM 1.89314943982217 0.0224307347445504 no 146 0.0291689994807147 273 748649 SGTC_1738 st035555 74 µM 1.88377105523073 0.022953751180669 no 147 0.0297979751831336 289 5331140 SGTC_776 4476-4378 112 µM 1.88156897185335 0.0230780358358169 no 148 0.0299472811951714 220 2892008 SGTC_3315 9136395 68.55 µM 1.87641984208534 0.0233708637620149 no 149 0.0302988260363469 246 16876844 SGTC_705 1124-0212 310 µM 1.87570884662701 0.0234115422749743 no 150 0.0303476352378194 272 9554485 SGTC_2915 7971052 15.16 µM 1.87336328168495 0.0235461628757211 no 151 0.0305091184003552 155 5741558 SGTC_2441 5730946 39.09 µM 1.86245792449484 0.0241806425695875 no 152 0.0312692854589502 269 1774275 SGTC_2219 9098279 200 µM 1.86171713786351 0.0242242579162817 no 153 0.0313214858075608 233 902349 SGTC_2744 captopril 92.04 µM 1.86153704452091 0.0242348712629548 no 154 0.0313341871671664 183 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_704 1310-0270 142 µM 1.85084958753876 0.0248717388119984 no 155 0.0320955974736806 314 5718033 SGTC_759 3486-0358 89.3 µM 1.84785346787391 0.0250527767160049 no 156 0.0323117717940278 284 875103 SGTC_396 dithiazanine 1.25 µM 1.84523205863188 0.0252120778889047 no 157 0.0325018944457524 207 10578 An antihelmenthic. SGTC_273 hydroxyurea 18.1 mM 1.84073044256163 0.0254876180854517 no 158 0.0328305352202276 327 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2690 usnic acid 100 µM 1.82176897882101 0.0266760665771121 no 159 0.0342450232743477 317 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_798 1287-0182 476 µM 1.8212145915351 0.0267114988555045 no 160 0.0342871216370518 316 1649755 SGTC_3340 9146634 11.102 µM 1.82002666213273 0.0267875547547338 no 161 0.0343774723530763 260 4907387 SGTC_2387 9077560 195.08 µM 1.81793621398186 0.0269218325263507 no 162 0.0345369412499677 284 5303272 SGTC_985 1493-0307 8.71 µM 1.81775830898966 0.0269332859679136 no 163 0.0345505406651828 218 3278274 SGTC_906 1165-0455 526 µM 1.81163062690334 0.0273302731697588 no 164 0.0350216446666839 239 3252859 SGTC_173 1273-0061 2.693 µM 1.79714263458772 0.0282883317584798 no 165 0.0361564893846071 410 2847414 YPL266W DIM1 SGTC_628 1636-0253 16 µM 1.792400111544 0.028607953354508 no 166 0.0365344484769235 321 4456143 SGTC_2639 lactacystin 53 µM 1.79074179656569 0.0287204216123226 no 167 0.0366673695837937 300 3870 A proteasome inhibitor. SGTC_1013 4112-3890 241 µM 1.78616960259446 0.0290324171420977 no 168 0.0370359006221779 302 705171 SGTC_802 4112-3352 742 µM 1.78321930250611 0.0292352296370674 no 169 0.03727530576711 323 704594 SGTC_127 0180-0333 59.125 µM 1.78200797970246 0.029318839695114 no 170 0.0373739652318822 389 771601 SGTC_1338 1486-1223 76 µM 1.77548871378733 0.0297722410811321 no 171 0.0379086137295154 299 3444526 SGTC_2481 5478948 45.16 µM 1.77152191419925 0.0300509595783675 no 172 0.0382369759150782 307 77792 SGTC_1223 0764-0573 147 µM 1.76686567887802 0.0303808764675356 no 173 0.0386253630356932 333 1609797 SGTC_2204 7233102 200 µM 1.76523906811839 0.0304968347597099 no 174 0.0387617975905334 227 2172480 SGTC_900 1112-0045 141 µM 1.76517264773346 0.0305015775355032 no 175 0.0387673770372582 217 56211 YIL048W NEO1 SGTC_2532 xanthone 78.9 µM 1.7585076099592 0.0309806135931323 no 176 0.0393305889416435 294 7020 An insecticide. SGTC_1307 1187-1599 12.2 µM 1.75672237473402 0.0311099756739301 no 177 0.0394825709241861 288 1538471 SGTC_2257 7960413 200 µM 1.75390942720527 0.0313147146451476 no 178 0.0397230139955506 337 2974689 YIL048W NEO1 SGTC_3106 9121286 49.47 µM 1.75252698310004 0.0314157427801162 no 179 0.039841617127853 268 15943471 SGTC_1163 k060-0048 49.9 µM 1.74942174697366 0.0316436541505767 no 180 0.0401090722332419 341 6809982 SGTC_39 0986-0283 58.349 µM 1.74258184094117 0.0321504964256168 no 181 0.040703342137474 365 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_664 1222-0054 14.9 µM 1.74036116172271 0.0323164845557207 no 182 0.0408978103604758 325 6813991 SGTC_374 0880-0231 82.3 µM 1.73921363731738 0.0324025348142853 no 183 0.0409985957792556 318 6833587 SGTC_572 0960-0087 17.7 µM 1.73902478293702 0.0324167146775244 no 184 0.0410152018759733 380 6796365 SGTC_97 0535-0701 19.132 µM 1.73311551453255 0.032862996589948 no 185 0.0415375696718963 275 2832013 YGL099W LSG1 SGTC_747 3448-8087 38.7 µM 1.7304916875054 0.0330627715176626 no 186 0.0417712325564646 334 5168703 SGTC_918 glabranin 770.725 nM 1.72909052929816 0.0331698631586575 no 187 0.0418964469548186 330 124049 Also referred to as licorice root. SGTC_2480 5767542 37.17 µM 1.72757061669614 0.0332863542284949 no 188 0.0420326172791302 285 2867358 SGTC_639 0833-0042 114 µM 1.72130138458421 0.033770415112593 no 189 0.0425980741892124 349 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1256 0570-0116 285 µM 1.71855785922489 0.0339840629725228 no 190 0.0428474552593221 291 410638 SGTC_683 panaxydol 45 µM 1.7100236459288 0.0346557690098429 no 191 0.0436307502861469 333 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1750 st081859 2.357 µM 1.70846271337629 0.0347797978396889 no 192 0.0437752596417312 556 5291695 SGTC_480 am 92016 50 µM 1.70621569508798 0.0349589815274756 no 193 0.04398396379231 268 2129 K+ channel blocker. SGTC_41 0478-0632 82.643 µM 1.70405608469544 0.035131908438848 no 194 0.0441853049450376 384 3750424 SGTC_1289 0976-0073 69.1 µM 1.69924859907324 0.0355193800384133 no 195 0.0446361764703736 325 3391136 SGTC_973 1325-0077 65.9 µM 1.6973063012266 0.0356769150087647 no 196 0.0448193832800533 343 2835149 SGTC_2370 9071495 200 µM 1.69415210012393 0.035933964197618 no 197 0.0451181921117069 333 21791103 SGTC_432 NS 1619 61.3 µM 1.69167610807495 0.0361368044562005 no 198 0.045353873132523 306 4552 A K+/calcium channel activator. SGTC_1205 4161-2785 76 µM 1.68857666440348 0.0363920400470589 no 199 0.0456502928821083 302 3498106 SGTC_2884 9058502 51.95 µM 1.6862381138825 0.036585591965663 no 200 0.0458749727591092 343 6471554 SGTC_2662 daunorubicin 22.37 µM 1.68445080214211 0.036734087299603 no 201 0.0460472899117572 287 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2424 5537928 59.2 µM 1.68279573627921 0.0368720344757266 no 202 0.0462073203607293 378 5382802 SGTC_693 4161-2696 114 µM 1.67711189444547 0.0373490022158085 no 203 0.0467603016528032 265 805759 SGTC_1508 1080-0625 72.9 µM 1.67635720702957 0.0374127102425175 no 204 0.0468341228398531 305 767111 SGTC_2946 9065502 71.43 µM 1.67545560737881 0.0374889364052161 no 205 0.046922437044312 196 16489101 SGTC_2900 5328528 85.29 µM 1.67305076166739 0.0376928756823818 no 206 0.0471586517273895 385 795359 SGTC_1655 st012546 55.1 µM 1.66959057262768 0.03798789985237 no 207 0.0475001984472762 306 720985 YLR208W SEC13 SGTC_1281 0884-0031 11.8 µM 1.66121543370063 0.038709787786816 no 208 0.0483350934849967 374 1548255 SGTC_1313 1220-0047 237 µM 1.66015935778124 0.0388016036421932 no 209 0.0484411991662446 402 3528706 SGTC_2659 sanguinarine 24.21 µM 1.65960044808881 0.0388502673117175 no 210 0.0484974290723043 327 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2323 6148992 148.28 µM 1.65616827255996 0.0391501940775219 no 211 0.0488438732329159 302 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1325 1431-0015 227 µM 1.65020475716785 0.0396758071292551 no 212 0.0494505320942664 305 1103340 SGTC_979 1426-2828 121 µM 1.6473994723477 0.0399250366381222 no 213 0.0497379818770655 393 747872 SGTC_1641 st009299 47.1 µM 1.64562856612335 0.0400830231127537 no 214 0.0499201270765385 266 4046054 SGTC_2839 9003951 25.97 µM 1.64530258245577 0.0401121601221166 no 215 0.0499537137806246 313 2990634 SGTC_1782 st039423 80.636 µM 1.62824594783189 0.0416608786324385 no 216 0.0517363727943798 339 2068169 SGTC_1891 st059073 26.2 µM 1.6273980984285 0.0417391085659787 no 217 0.0518262875693033 377 688754 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.61800979818361 0.0426133312381265 no 218 0.0528302430435265 441 688664 SGTC_1421 4029-0249 71.4 µM 1.61560608688347 0.0428395252958058 no 219 0.0530897535244841 377 2894095 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.60754926465875 0.0436047740496727 no 220 0.0539669657706455 353 16623 A steroid. SGTC_1567 st069303 68.4 µM 1.60637864969318 0.0437168730483732 no 221 0.0540953695055163 400 5581319 SGTC_2270 7924575 90.91 µM 1.6055866038139 0.0437928517783088 no 222 0.0541823853939697 371 1262135 SGTC_779 1360-0071 233 µM 1.60464745992917 0.0438830792086016 no 223 0.054285705281644 385 7566 SGTC_1780 st038448 24.544 µM 1.60406757907828 0.0439388655909207 no 224 0.0543495786572007 358 728868 YDL195W SEC31 SGTC_3244 9134489 49.47 µM 1.59528130524775 0.0447911524041097 no 225 0.0553246721062732 357 16584271 SGTC_400 oxethazaine 37.5 µM 1.5948468612024 0.0448336373559165 no 226 0.0553732424882682 355 4621 A local anesthetic. SGTC_2126 5251174 33.877 µM 1.59159664419398 0.0451525113464778 no 227 0.0557376822999831 456 790722 SGTC_2056 5235370 200 µM 1.59021246336883 0.0452888642074467 no 228 0.0558934610483816 398 5511916 SGTC_1330 1469-0054 61.8 µM 1.58831772806404 0.045476047591231 no 229 0.0561072553509255 362 7102664 SGTC_2008 4012253 172 µM 1.5842820125161 0.0458768150439978 no 230 0.0565647786255277 417 603940 SGTC_2935 9038016 29.96 µM 1.581269303174 0.0461778388952275 no 231 0.0569082376138598 406 6463195 SGTC_2330 7979373 200 µM 1.58042492432527 0.046262491531129 no 232 0.0570047936938734 404 1863007 SGTC_875 0709-0210 25.7 µM 1.5802714785039 0.0462778885109009 no 233 0.057022354312184 414 6251364 SGTC_597 k018-0003 82.8 µM 1.57504176167308 0.0468051103840781 no 234 0.0576234026561549 381 6786234 SGTC_3215 9129942 49.47 µM 1.56870918725961 0.0474499518014204 no 235 0.0583578584464236 329 17682944 SGTC_1105 epirubicin 18.1 µM 1.56609826090354 0.0477178843851693 no 236 0.0586628075918756 389 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_919 tnp00227 403.569 nM 1.56600025416373 0.0477279653555468 no 237 0.0586742788266603 438 1269246 A methoxyflavone. YNL221C POP1 SGTC_1418 3966-3099 2.4 µM 1.56354556538362 0.0479810113104383 no 238 0.0589621635008964 414 740335 SGTC_1327 1436-0082 2.18 µM 1.56342452740396 0.0479935164527763 no 239 0.0589763873931015 371 15992205 SGTC_4 0960-0234 25.671 µM 1.56202955327049 0.0481378277564451 no 240 0.0591405134601752 365 6821112 SGTC_2000 st075254 36.4 µM 1.55787065424412 0.0485701310768376 no 241 0.0596319564781175 333 17234175 SGTC_2918 7977171 22.06 µM 1.55701819616406 0.0486591233540346 no 242 0.0597330826512523 365 2236483 SGTC_2161 5662504 8.5105 µM 1.55663853634098 0.0486987998349759 no 243 0.0597781645065386 373 2859334 SGTC_2147 5545932 89.7195 µM 1.55511174508198 0.0488586188575653 no 244 0.0599597290993877 367 797404 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.55270027889921 0.0491118959500881 no 245 0.0602473778381285 429 688667 SGTC_2215 7188065 200 µM 1.54973818115367 0.0494244400764333 no 246 0.0606021849962198 310 940217 SGTC_1758 st042942 75.2445 µM 1.54765381054377 0.0496453215256401 no 247 0.0608528341829536 376 669317 SGTC_477 mead ethanolamide 10 µM 1.54426844656392 0.050005747523058 no 248 0.0612616566238348 223 16061185 SGTC_38 0929-0051 58.268 µM 1.53885075469406 0.0505868855722949 no 249 0.0619203678895267 436 1379719 SGTC_517 1365-0151 113 µM 1.53318302189268 0.0512005894963768 no 250 0.0626153831506429 397 768657 SGTC_333 3486-0131 40.1 µM 1.53109879278755 0.0514277547020255 no 251 0.0628724890764956 381 6744690 SGTC_1496 4469-0713 57.4 µM 1.52744700593793 0.0518277038003699 no 252 0.0633249476844806 407 746691 SGTC_249 wiskostatin 11.211 µM 1.52700925462892 0.0518758124428936 no 253 0.0633793550509624 383 2775510 A n-wasp and actin depolymerizer. SGTC_341 1486-1430 230 µM 1.5267675486744 0.051902391005309 no 254 0.0634094118621734 401 2054753 YPL210C SRP72 SGTC_2748 diazoxide 86.69 µM 1.52544010123913 0.0520485532464224 no 255 0.0635746814948596 331 3019 A potassium channel activatior. SGTC_369 0957-0393 4.5 µM 1.52145241946257 0.052489595134736 no 256 0.0640731714407809 392 6997992 SGTC_2983 9022671 12.99 µM 1.51711858071077 0.0529722809340402 no 257 0.0646183739222073 383 6405161 SGTC_2384 9036245 200 µM 1.51552008226607 0.0531512015114951 no 258 0.0648203742748435 427 6462766 SGTC_1935 st074532 41.6 µM 1.51254328603484 0.0534856721596292 no 259 0.0651978547646098 498 2829742 SGTC_142 0335-0849 62.6745 µM 1.51215107078592 0.0535298652485572 no 260 0.0652477175666416 552 3889043 YPR107C YTH1 SGTC_2094 5332512 191.667 µM 1.51123985212049 0.0536326490428409 no 261 0.0653636761194102 420 755774 SGTC_20 0481-0013 4.944 µM 1.50928207768776 0.0538540111615989 no 262 0.0656133563930344 429 182045 SGTC_2479 5617353 43.85 µM 1.50801405033454 0.0539977703912947 no 263 0.0657754655259602 422 2731746 SGTC_152 4469-0003 551.229 µM 1.50454919082208 0.0543921390616899 no 264 0.0662200087567422 393 697280 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.50262468986334 0.0546121670442855 no 265 0.0664679264449463 317 77254 SGTC_1555 citronellol 128 µM 1.50178927241632 0.0547078990330211 no 266 0.0665757698404022 368 8842 A terpine precursor. SGTC_1332 1480-0653 17.5 µM 1.49774101506279 0.0551736765984888 no 267 0.0671002755749362 437 5749438 SGTC_411 enrofloxacin 100 µM 1.4973680562646 0.0552167449789012 no 268 0.0671487576737548 395 71188 A bacterial gyrase inhibitor. SGTC_737 1950-0117 57.9 µM 1.49639158903046 0.0553296308342018 no 269 0.0672758200490223 417 5393513 SGTC_3119 9125183 49.47 µM 1.49541857908341 0.0554422982125475 no 270 0.0674026173569059 287 22695334 SGTC_2910 7948405 25.97 µM 1.49398617504045 0.0556084895639247 no 271 0.0675896163878883 375 2971328 SGTC_3075 9116269 49.47 µM 1.48518719748767 0.056638012524092 no 272 0.0687471212162513 414 17015205 YNL244C SUI1 SGTC_1077 5-fluorocytosine 377 nM 1.48504308749718 0.0566549982333504 no 273 0.0687662053024696 403 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2505 galangin 7.89 µM 1.48443627719686 0.0567265647397783 no 274 0.06884660832308 353 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_781 4335-2806 94.4 µM 1.4816683549004 0.0570539139516788 no 275 0.0692142806067395 488 845254 SGTC_947 3447-0010 211 µM 1.47506758390001 0.0578405582558907 no 276 0.0700971872180554 407 748350 SGTC_1637 st007924 17.4 µM 1.47312822836095 0.0580732935965802 no 277 0.0703582315723457 434 683336 SGTC_2782 7736369 71.43 µM 1.46902104657479 0.0585686113657955 no 278 0.0709135403782108 475 2950836 YOL077C BRX1 SGTC_1171 0368-0077 21.4 µM 1.46733795738283 0.0587725441112204 no 279 0.0711420714692231 399 3239779 SGTC_2130 NSC 7 2.4545 µM 1.46402773657762 0.0591752549585827 no 280 0.0715931850102403 468 21448 SGTC_2421 5690543 90.72 µM 1.46279511073232 0.0593257640413043 no 281 0.0717617256739027 436 3397993 SGTC_428 3448-4153 16.5 µM 1.45987586749043 0.0596834137327593 no 282 0.0721620963715479 395 3834874 SGTC_261 5-fluorouridine 15.376 µM 1.45883400075801 0.0598114658343774 no 283 0.0723054009700285 440 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1778 st046819 58.9 µM 1.45598958653683 0.0601621585694426 no 284 0.0726977491678621 517 671715 SGTC_1714 st033236 13.627 µM 1.45216387525013 0.0606363732820519 no 285 0.0732280223241374 470 2916566 SGTC_863 0466-0191 129 µM 1.45182860077426 0.0606780710705572 no 286 0.0732746346244587 512 765160 YPR165W RHO1 SGTC_2870 9038528 12.99 µM 1.44943330560555 0.0609766246095897 no 287 0.0736083065981168 410 6463316 SGTC_2975 9084847 53.72 µM 1.44941163462557 0.0609793309485864 no 288 0.0736113307260271 460 27211724 SGTC_2942 9052777 62.25 µM 1.44915623457125 0.0610112331720509 no 289 0.0736469782847154 502 6469503 SGTC_2925 9010536 32.5 µM 1.44694094695436 0.0612884941396115 no 290 0.0739567317953262 534 2994177 SGTC_3342 9147791 14.508 µM 1.44665430674109 0.0613244412720283 no 291 0.0739968840100863 439 1838168 SGTC_1104 tacrolimus 29.8 µM 1.44505506839196 0.0615253018346288 no 292 0.0742212091366371 484 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_843 0310-0051 143 µM 1.4449999863903 0.0615322291463063 no 293 0.074228944730085 445 2065037 SGTC_2268 7933382 153.85 µM 1.44481541875542 0.0615554454795793 no 294 0.0742548694853747 529 935025 YOR257W CDC31 SGTC_2283 7944793 200 µM 1.44379346997814 0.0616841178611492 no 295 0.0743985397003707 471 2970533 SGTC_549 1661-1316 519 µM 1.44058128723521 0.0620899277642056 no 296 0.0748515050722633 458 2857282 SGTC_1073 triclabendazole 3.09 µM 1.44046403259646 0.0621047803957541 no 297 0.0748680794280712 530 50248 An antihelmetic and likely tubulin inhibitor. SGTC_957 1187-1561 14.1 µM 1.43687301759045 0.0625609976008684 no 298 0.0753770390331397 477 1538454 SGTC_1197 1601-0112 267 µM 1.42934772746788 0.0635255114634061 no 299 0.0764521572748134 509 7350313 SGTC_1835 st008666 49.2 µM 1.42911881649546 0.0635550312515903 no 300 0.0764850430683601 387 690455 SGTC_2543 pimpinellin 60.67 µM 1.42678576415094 0.0638565050093876 no 301 0.0768208278886708 443 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2525 harmine 47.85 µM 1.42658185402828 0.0638829067537911 no 302 0.0768502288521321 391 5280953 A monoamine oxidase inhibitor SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.42613255441497 0.0639411108429314 no 303 0.0769150417091151 580 6708739 YPR165W RHO1 SGTC_1181 1222-0449 220 µM 1.42322014737621 0.0643193963959044 no 304 0.0773361734286098 457 658318 SGTC_1230 0170-0365 3.77 µM 1.42050591799742 0.0646735046894897 no 305 0.0777302234630689 623 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_926 2268-1401 59.4 µM 1.41436558007487 0.0654801815292166 no 306 0.0786272954005145 486 2931578 SGTC_2459 5811157 9.22 µM 1.40540299782777 0.0666716058265226 no 307 0.0799507379072458 456 2870684 YBR192W RIM2 SGTC_940 3232-1287 54.8 µM 1.40037402158407 0.0673474330272418 no 308 0.0807006725906285 482 1585493 YIL048W NEO1 SGTC_2129 girgensonine 121.053 µM 1.39685343485689 0.0678236954342617 no 309 0.0812288249062968 546 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_949 1165-0505 146 µM 1.39382244314457 0.0682358059266561 no 310 0.0816856145515275 524 6244267 SGTC_1767 st044992 70.3 µM 1.39083463516944 0.0686439337660798 no 311 0.0821377888466873 499 9600693 SGTC_1895 st058434 18.3 µM 1.38710714298374 0.0691557371765951 no 312 0.0827045471214469 492 5393175 SGTC_2261 9010538 184.68 µM 1.3855962106362 0.0693640313266299 no 313 0.0829351179866844 404 6457250 SGTC_501 nsc-95397 161 µM 1.38496558678023 0.0694511106881516 no 314 0.0830314951689242 456 262093 SGTC_1132 3456-3614 2.5 µM 1.38023036463095 0.0701076631218343 no 315 0.0837578638115621 599 3125502 SGTC_2552 juarezic acid 87.02 µM 1.37837588128012 0.0703660899057905 no 316 0.0840436330032111 572 1549512 SGTC_669 0108-0021 26.2 µM 1.37289238375162 0.0711345141775086 no 317 0.0848929023289499 622 17201 SGTC_3030 9087619 49.47 µM 1.37219699747799 0.0712324200379397 no 318 0.0850010599374512 478 25236973 SGTC_511 blebbistatin 171 µM 1.36772039369021 0.0718651751566176 no 319 0.0856998069436433 485 3476986 A myosin inhibitor. SGTC_299 1273-0059 1.44 µM 1.36534841639774 0.0722021898287809 no 320 0.0860717842012629 486 2848077 SGTC_1903 st060211 78.3 µM 1.36478621682545 0.0722822454199173 no 321 0.086160126054677 515 688960 SGTC_2473 5854593 8.94 µM 1.36355008782879 0.0724585057960263 no 322 0.0863546050465913 463 2872951 SGTC_2944 9067346 25.62 µM 1.36161380725536 0.0727352628028433 no 323 0.0866598977501977 513 6473075 SGTC_3096 9117468 49.47 µM 1.35943590120143 0.0730475223348966 no 324 0.0870042506021063 382 41316311 SGTC_112 phenothiazine 287.218 µM 1.35769663513009 0.0732976273839714 no 325 0.0872799824770778 517 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1345 1488-0192 31.4 µM 1.35731291275326 0.0733528944518396 no 326 0.0873409030651042 514 658348 SGTC_2597 laccaic acid a 100 µM 1.3530818063024 0.0739644107866491 no 327 0.0880147486346231 532 5491415 A textile dye. SGTC_2003 4023581 200 µM 1.35185941861867 0.0741418041508004 no 328 0.0882101458488069 511 16641307 SGTC_643 k048-0106 28.4 µM 1.34810106632348 0.0746892534910235 no 329 0.088812939264781 517 6763920 SGTC_363 0455-0021 3.06 µM 1.34787270011625 0.0747226169313978 no 330 0.088849664997098 542 4597466 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.34758352630036 0.0747648804499578 no 331 0.0888961859998386 553 5106787 A p450 inhibitor. SGTC_2890 9046729 58.44 µM 1.34662609796556 0.074904941306683 no 332 0.0890503422473927 453 903329 SGTC_3322 9139058 2.11 µM 1.34642219927746 0.0749347951968676 no 333 0.0890831978102029 507 4908926 YPR165W RHO1 SGTC_1340 1486-1359 257 µM 1.34540534833935 0.0750838132550081 no 334 0.0892471845178485 507 4309068 SGTC_2776 terbinafine 19.92 µM 1.34103904057094 0.0757262590218592 no 335 0.0899538887247216 500 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_289 k017-0060 526 µM 1.34033614663464 0.0758300709167967 no 336 0.0900680424353265 470 5512909 SGTC_3190 9110366 49.47 µM 1.34027021860705 0.0758398135240134 no 337 0.0900787550159731 431 17123768 SGTC_506 n9-isopropylolomoucine 153 µM 1.33766169344422 0.0762260575260424 no 338 0.090503371786094 500 6610355 SGTC_699 0375-0592 111 µM 1.33544794105731 0.0765550204262825 no 339 0.0908648914751242 530 762578 SGTC_206 4546-0025 72.014 µM 1.33249150784464 0.076996028090365 no 340 0.0913493650858412 603 6620745 YIL048W NEO1 SGTC_235 0330-0087 5 mM 1.32984293718146 0.0773927496522274 no 341 0.0917850128368909 550 46494818 YHR062C RPP1 SGTC_2491 paeonol 100 µM 1.32970292201474 0.0774137652364646 no 342 0.0918080858621095 457 11092 Increases levels of cortical cytochrome oxidase. SGTC_635 k038-0028 24.7 µM 1.32083182477033 0.0787541282540608 no 343 0.0932787228512148 546 4035102 SGTC_1862 st057513 3.81 µM 1.31926633987776 0.0789924770611574 no 344 0.0935400433564153 506 5393163 SGTC_1200 1643-0193 18.4 µM 1.31451170774798 0.0797197309529036 no 345 0.0943370303942037 576 5403974 SGTC_446 go6976 132 µM 1.30558228248363 0.0810992196780406 no 346 0.0958473243646386 500 3501 A protein kinase C inhibitor. SGTC_1368 1852-0141 284 µM 1.30212990415767 0.0816373728361947 no 347 0.0964359910361746 529 2838987 SGTC_2671 danthron 100 µM 1.29927840890393 0.0820838876181557 no 348 0.0969242006430348 537 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1397 3532-0190 20.1 µM 1.29853115815276 0.0822012030783478 no 349 0.097052438329934 457 5322280 SGTC_1934 st074720 32.6 µM 1.29766222968975 0.0823377802244242 no 350 0.0972017140066525 601 17250992 SGTC_2585 alliin 100 µM 1.29560641978526 0.0826615902920013 no 351 0.097555558122033 585 87310 A garlic compound which reacts with lipids. SGTC_864 0469-0573 172 µM 1.29550736330706 0.0826772168192413 no 352 0.0975726314557029 537 689425 SGTC_1596 piperlongumine 63 µM 1.2937385718481 0.0829566246478597 no 353 0.0978778686136941 601 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1515 3460-0031 42.1 µM 1.29352110990689 0.082991025080309 no 354 0.0979154438880738 474 2876596 SGTC_598 3937-0236 20.2 µM 1.29347594710114 0.0829981707565348 no 355 0.0979232489002315 610 1379313 SGTC_3313 9133968 57.047 µM 1.29084081814551 0.0834159035522141 no 356 0.0983794402813752 580 1494643 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.28847088954439 0.0837929434999948 no 357 0.0987910479433505 600 688801 SGTC_2986 9022445 71.43 µM 1.28172069040754 0.0848738699976204 no 358 0.0999703220851518 543 6459286 SGTC_2308 7584454 197.62 µM 1.27755324727914 0.0855464128485456 no 359 0.100703497152521 622 893577 SGTC_1737 st035557 69.7 µM 1.27590895193671 0.0858128647180064 no 360 0.100993853105849 463 5716916 SGTC_148 3253-0744 288.01 µM 1.27587167725022 0.085818912132988 no 361 0.101000442278993 541 6893655 SGTC_3024 9090631 49.47 µM 1.27285021977555 0.0863101725196395 no 362 0.101535598331912 520 25236383 SGTC_3294 9122953 26.2835 µM 1.27212532085878 0.0864283464245225 no 363 0.101664297948765 583 16459826 SGTC_2061 5245884 80.95 µM 1.27190873102094 0.0864636786265352 no 364 0.101702774662784 583 573863 SGTC_854 0422-0053 192 µM 1.26942965378814 0.0868688588610217 no 365 0.102143932717646 558 3596728 SGTC_2629 bisabolol 100 µM 1.26524369544036 0.0875562289254441 no 366 0.102891991632853 598 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1658 st012944 20 µM 1.26360881182586 0.0878257901153791 no 367 0.103185234614734 592 24207260 SGTC_2024 5144227 134 µM 1.25852074298565 0.0886686766593873 no 368 0.104101745140507 621 3475211 SGTC_2223 6903751 107.57 µM 1.25704357328901 0.0889145086193023 no 369 0.104368928913435 526 5598863 SGTC_50 0929-0078 56.389 µM 1.25651800775075 0.0890020959975713 no 370 0.104464110584678 570 1377751 SGTC_3339 9145883 14.936 µM 1.25037532067998 0.0900305630589947 no 371 0.105581237767633 535 2030670 SGTC_2743 auranofin 4.32 µM 1.2479283245994 0.090442712803201 no 372 0.106028653373784 545 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1277 0873-0036 22 µM 1.24719736650688 0.0905661000598032 no 373 0.106162569151992 637 5965735 SGTC_2902 5787006 60.46 µM 1.2469218915915 0.0906126332086718 no 374 0.106213069447228 560 591003 SGTC_2248 tofa 1.1 µM 1.24646367148314 0.0906900749346458 no 375 0.106297109178679 548 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3170 9103054 49.47 µM 1.24059799242392 0.0916857499094336 no 376 0.10737714698036 543 16432970 SGTC_874 0599-0792 117 µM 1.24007085270796 0.0917756247993796 no 377 0.107474594343033 679 765305 SGTC_1975 st070967 30.8 µM 1.23792363852476 0.0921423892974313 no 378 0.107872188204011 662 261391 SGTC_2763 lisinopril 49.32 µM 1.23770331222931 0.0921800844085787 no 379 0.107913045278019 545 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_272 doxorubicin 8.13 µM 1.23448906766935 0.0927313006592572 no 380 0.108510358976894 657 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2823 7987624 58.44 µM 1.232525212198 0.0930692830914083 no 381 0.108876477280752 623 2239440 SGTC_820 1582-0060 59.9 µM 1.23163261079042 0.0932232017270343 no 382 0.109043176714188 610 3848840 SGTC_1169 aniline yellow 25.8 µM 1.22770957160669 0.0939019141322284 no 383 0.109778006018551 558 6051 A DNA damaging agent. SGTC_1270 0831-1170 17.3 µM 1.22459367657915 0.0944435784098115 no 384 0.110364175805269 658 6764716 SGTC_1642 st009582 77.7 µM 1.22281682233503 0.0947534947663395 no 385 0.110699445096954 563 6739311 SGTC_304 1310-0298 97 µM 1.22096523286734 0.0950772430768707 no 386 0.111049591869418 605 1550234 SGTC_763 3453-1109 128 µM 1.22017144516495 0.0952162851881361 no 387 0.111199944588261 625 1560353 SGTC_2751 anetholtrithion 17.25 µM 1.21762699719158 0.0956629870733888 no 388 0.111682875180157 601 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1875 nocodazole 6 µM 1.21578102282827 0.0959880291359048 no 389 0.112034174891744 605 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1771 st048882 4.1505 µM 1.21477777826259 0.096165022290816 no 390 0.112225429213241 616 4580403 SGTC_2873 9040596 71.43 µM 1.21141984032924 0.0967591775345553 no 391 0.112867269617992 615 6463863 SGTC_1625 st003711 30.1 µM 1.21002929590926 0.0970060089413606 no 392 0.113133825825915 596 24207034 YER133W GLC7 SGTC_3105 9121040 49.47 µM 1.20896335612463 0.0971955334740699 no 393 0.113338461852964 375 41448907 SGTC_1461 k072-0203 53.8 µM 1.2064563020692 0.0976423595244105 no 394 0.113820799186306 589 5418714 SGTC_1372 2752-0194 270 µM 1.20429480858039 0.09802880470914 no 395 0.114237826254753 567 823334 SGTC_2263 7948595 193.29 µM 1.19591307220098 0.099537942992344 no 396 0.115865241667208 557 2971371 SGTC_580 1123-0028 41 µM 1.19568417557718 0.0995793928665997 no 397 0.115909914465205 696 1677248 YPR107C YTH1 SGTC_398 bronopol 33.3 µM 1.19304271915476 0.100058635436302 no 398 0.116426321503164 632 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1157 4092-0394 27.6 µM 1.19197284536126 0.100253222342868 no 399 0.116635946467928 685 3659885 SGTC_466 geldanamycin 89.2 µM 1.19001153074188 0.100610660103974 no 400 0.117020930011509 493 5288382 HSP90 inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 1.18373976805482 0.101759888796229 no 401 0.118258045781648 597 16667744 Haematoxylin. SGTC_2670 beta-carotene 100 µM 1.18288129697359 0.101917934377173 no 402 0.118428097491338 542 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1527 coumarin 137 µM 1.18199926191309 0.102080504106556 no 403 0.11860299686114 575 323 A hepatotoxic, DNA x-linker. SGTC_2644 guaiazulene 100 µM 1.1816279741601 0.102148993327054 no 404 0.118676674336887 618 3515 A coloring agent. SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.18102503249553 0.102260285564577 no 405 0.118796389558492 694 1273210 SGTC_1978 st071761 42 µM 1.17942853585407 0.102555396139485 no 406 0.119113788916663 602 5147680 SGTC_1189 1431-2119 7.28 µM 1.17813985940799 0.102794057703469 no 407 0.119370426872954 671 3107275 SGTC_2243 6634756 200 µM 1.17710911319727 0.102985241162463 no 408 0.11957597908274 586 885676 SGTC_1078 idebenone 36.1 µM 1.17441616837313 0.103485948952848 no 409 0.120114186108611 693 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1696 st025591 34.7925 µM 1.1717519799437 0.103983046326137 no 410 0.120648323565873 653 2787147 SGTC_3058 9093861 49.47 µM 1.17155950540493 0.104019026123441 no 411 0.120686977043816 632 17217477 SGTC_1142 3253-1408 9.78 µM 1.16572725815982 0.105113548772482 no 412 0.121862367853895 622 256655 SGTC_1 0258-0098 57.368 µM 1.16224915639545 0.105770229594769 no 413 0.122567136315957 568 6790032 YDR047W HEM12 SGTC_744 1594-0068 283 µM 1.1617567293278 0.105863441113472 no 414 0.122667147539427 717 668392 SGTC_937 3122-0005 46.7 µM 1.16087852055224 0.106029824583731 no 415 0.122845652522238 705 759535 SGTC_3098 9119039 49.47 µM 1.15354605126122 0.107426396663752 no 416 0.124343163561849 660 17161528 SGTC_2519 cryptotanshinone 88.04 µM 1.15081695471507 0.107949562594432 no 417 0.124903774056223 648 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_199 4063-0024 41.6 µM 1.14945227840354 0.108211857136582 no 418 0.125184766904722 677 306215 SGTC_2859 9028643 45.46 µM 1.1484014928467 0.108414133381386 no 419 0.125401428853705 617 17151580 SGTC_1293 1000-1278 195 µM 1.14837034209606 0.108420134050986 no 420 0.125407855833365 686 678847 SGTC_1661 st013063 9.66 µM 1.14789727347776 0.108511292158591 no 421 0.125505486953638 718 721395 SGTC_2066 5222451 176 µM 1.14510946493846 0.109049609805627 no 422 0.12608190759667 714 2281147 SGTC_1885 st057546 99.9 µM 1.14504119949187 0.109062815695564 no 423 0.126096045599964 697 702008 SGTC_1046 2001-0062 216 µM 1.14061485679418 0.109921542596185 no 424 0.127015115988188 653 739778 SGTC_2876 9059903 25.97 µM 1.13906885755005 0.110222612476413 no 425 0.127337217743895 725 6916095 SGTC_2444 5485484 36.41 µM 1.13683891670979 0.110657915108431 no 426 0.127802815621668 705 6790631 SGTC_2186 6124449 200 µM 1.13433382423604 0.11114839748785 no 427 0.128327273055383 664 3834182 YLR033W RSC58 SGTC_1265 0819-1001 68.8 µM 1.13241192428906 0.111525748083914 no 428 0.128730646988703 640 3106768 SGTC_2267 7931562 200 µM 1.12935473128344 0.112127892376693 no 429 0.129374110601973 607 934880 SGTC_725 1497-0963 19 µM 1.12812918502813 0.112369927148938 no 430 0.129632682612586 703 3549977 SGTC_292 k038-0015 474 µM 1.12667066014351 0.112658459381965 no 431 0.129940875871142 633 46368540 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.12489352224064 0.113010735716084 no 432 0.130317078638535 662 4330530 SGTC_1334 1486-0610 236 µM 1.12340680044236 0.113306047192915 no 433 0.130632381467298 702 3742339 SGTC_1701 st028638 40.4 µM 1.12260254599985 0.113466027615149 no 434 0.130803166802071 696 3490878 SGTC_2122 5258151 111.688 µM 1.12245555820062 0.113495283487589 no 435 0.130834396681656 689 2173356 SGTC_1389 3405-0187 19 µM 1.11958820542836 0.114067066312962 no 436 0.131444641994831 630 799890 SGTC_73 0327-0325 16.231 µM 1.11912653405622 0.114159320306316 no 437 0.131543080725474 775 53298 SGTC_402 epigallocatechin gallate 10 µM 1.11877117404393 0.114230366700545 no 438 0.131618886130299 716 65064 An antioxidant. SGTC_2254 7938975 95.19 µM 1.11769256148797 0.114446204301819 no 439 0.131849160393612 773 2969277 SGTC_3057 9095946 49.47 µM 1.1154911872677 0.11488761459092 no 440 0.132319996422579 697 24540043 SGTC_2447 5741742 33.78 µM 1.11383261809134 0.115220982871325 no 441 0.132675500416435 707 1776504 SGTC_1400 3771-8998 51.5 µM 1.11086408046436 0.115819367266312 no 442 0.133313429330968 638 670767 SGTC_590 k048-0076 22.4 µM 1.10603490268063 0.116797520272884 no 443 0.134355706362682 695 6832814 SGTC_1098 clofazimine 15.1 µM 1.10500726444678 0.117006422536894 no 444 0.134578220695113 741 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1652 st011932 78 µM 1.10330013180686 0.117354040055383 no 445 0.134948424701449 671 1551076 SGTC_1379 2144-0755 36.5 µM 1.10291658855981 0.117432240157998 no 446 0.135031694825067 758 5392327 SGTC_3270 9137563 49.47 µM 1.1022626044025 0.117565665168086 no 447 0.135173760960031 644 17015724 SGTC_350 k064-0020 19.8 µM 1.10156071428231 0.11770898325161 no 448 0.135326347771029 755 2790705 SGTC_2351 9026858 72.31 µM 1.10057471115544 0.11791052281447 no 449 0.135540898443823 658 1409300 SGTC_185 k048-0037 25.491 µM 1.09963111055859 0.118103623776225 no 450 0.135746440619519 745 6827589 SGTC_1398 3558-0053 112 µM 1.09285159434579 0.119497579684348 no 451 0.137229482118805 637 4532369 SGTC_2506 ethyl hematommate 54.16 µM 1.08766073691707 0.120572704215253 no 452 0.138372453466233 653 3940691 An allergen. SGTC_2493 resveratrol 26.09 µM 1.08616354341903 0.120884062917943 no 453 0.138703321668886 664 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2746 daunorubicin 9.88 µM 1.08526079928586 0.121072072211558 no 454 0.138903081374975 586 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_219 mitoxanthrone 164.414 µM 1.08424651034291 0.121283557590581 no 455 0.139127757366282 689 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2229 7354935 190 µM 1.08244403648379 0.121660025042254 no 456 0.139527634912615 662 318112 SGTC_2096 5468907 200 µM 1.08152433805671 0.121852430750692 no 457 0.139731970239116 711 759785 SGTC_587 k089-0003 57 µM 1.08013779787821 0.12214290608617 no 458 0.140040411192062 580 9659696 SGTC_1048 3161-0300 24.5 µM 1.07894627627908 0.122392913850614 no 459 0.140305838867777 738 2165101 SGTC_266 formosanin C 406 nM 1.07842493904477 0.122502414881173 no 460 0.140422081221011 737 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3017 9080681 49.47 µM 1.07724553979577 0.122750388056428 no 461 0.140685292631465 712 16451914 SGTC_615 k087-0205 167 µM 1.07617019136561 0.122976790799659 no 462 0.140925574231667 687 9642773 SGTC_1311 1190-0148 100 µM 1.07317102705563 0.123609778080063 no 463 0.141597193779544 843 1961333 SGTC_1410 3909-8106 77.9 µM 1.07181035238992 0.123897705755224 no 464 0.141902611150973 719 1039210 SGTC_2360 9040895 200 µM 1.07131218524067 0.124003238488699 no 465 0.142014541338767 672 4914414 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.06894212942887 0.124506177355049 no 466 0.142547873390989 782 676296 Flavone; oxidizing agent. SGTC_519 k048-0011 62.8 µM 1.06077849921837 0.12624945389047 no 467 0.144395287796675 732 6836379 SGTC_2088 5278280 127.392 µM 1.05913155308716 0.126603197967408 no 468 0.144769935892572 774 791502 SGTC_1783 st039459 87.517 µM 1.05374387015724 0.127765227593625 no 469 0.146000098912659 800 729761 SGTC_1647 st011722 22.4 µM 1.05328477925582 0.127864587166605 no 470 0.14610524634516 699 2854783 SGTC_1723 st034307 2.5525 µM 1.05193851259594 0.128156264893871 no 471 0.146413880447304 737 867466 SGTC_1058 3448-5425 97.3 µM 1.04315723599312 0.130070124415595 no 472 0.148437737860975 724 7279705 SGTC_3166 9102297 49.47 µM 1.04113027435804 0.13051469178511 no 473 0.148907545295807 760 25237072 SGTC_418 lividomycin a 100 µM 1.04015687263288 0.130728558095072 no 474 0.149133512260858 813 72394 An antibiotic. SGTC_1939 st074455 53.6 µM 1.03942940828895 0.130888547542141 no 475 0.149302536404613 782 1644229 SGTC_2716 st080858 38.6235 µM 1.03884331009848 0.131017545064331 no 476 0.149438807550068 799 5296050 SGTC_217 ketoconazole 989 nM 1.03777260284341 0.131253429562705 no 477 0.149687967350504 753 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3246 9135460 32.98 µM 1.03680376796879 0.131467123463979 no 478 0.149913659583285 690 41446951 SGTC_701 4424-0219 185 µM 1.03639243764425 0.131557922333863 no 479 0.150009548485716 843 2911779 SGTC_3155 9099265 49.47 µM 1.03583716060891 0.131680565278188 no 480 0.150139058949751 714 25236499 SGTC_194 1486-1323 56.904 µM 1.03520076043652 0.131821222731134 no 481 0.150287581867789 747 5178754 SGTC_450 aminopyrene 156 nM 1.03206836438422 0.132515056787901 no 482 0.151020046307359 788 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_746 1095-0025 46.6 µM 1.03203627736925 0.132522177142479 no 483 0.151027561652136 814 6749286 SGTC_2475 5812728 15.03 µM 1.03075956946358 0.13280570234059 no 484 0.151326791119369 797 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_198 3454-2873 16.191 µM 1.02958827386101 0.1330661852433 no 485 0.151601661071263 752 710957 SGTC_913 3487-1245 167 µM 1.02879049711051 0.133243802976543 no 486 0.151789066599644 736 4016153 SGTC_3234 9132280 49.47 µM 1.02823480216151 0.133367619750209 no 487 0.15191969567526 764 17612295 SGTC_1062 mesoridazine 14.2 µM 1.02686776208899 0.133672552595209 no 488 0.152241368128851 779 4078 A neuroleptic. SGTC_3323 9138564 53.9225 µM 1.02672818397771 0.13370371392799 no 489 0.152274237090914 847 43912313 YNL103W MET4 SGTC_1876 myriocin 605 nM 1.02431683757705 0.134242844477665 no 490 0.152842823793225 790 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1423 4048-0112 5.59 µM 1.0242942627114 0.134247898826754 no 491 0.152848153507793 797 X1423 SGTC_1809 st050081 57.6 µM 1.02171335270956 0.134826607689218 no 492 0.153458294712822 780 5036894 SGTC_982 1491-0518 27.5 µM 1.02124881168039 0.134930951662946 no 493 0.153568285823516 727 3091256 SGTC_2395 5646831 180.19 µM 1.01758488057519 0.13575587547408 no 494 0.154437637781401 786 6808628 SGTC_2313 7726885 200 µM 1.01741703855111 0.13579374719828 no 495 0.154477539945864 748 726423 SGTC_3306 9127676 59.7925 µM 1.01620337477504 0.136067812526086 no 496 0.15476627484078 748 41905287 SGTC_370 0180-0345 38.7 µM 1.01404878354623 0.136555286995897 no 497 0.155279737492493 707 3989527 SGTC_895 0964-0006 13.7 µM 1.013944897903 0.13657882117992 no 498 0.15530452295718 784 6738897 SGTC_389 tpck 16.7 µM 1.01365667402172 0.13664412974719 no 499 0.155373302268612 781 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3071 9117417 49.47 µM 1.0134243544927 0.136696786503411 no 500 0.15542875566616 687 45595590 YGL055W OLE1 SGTC_2677 mitomycin C 100 µM 1.01293482355206 0.136807787337402 no 501 0.155545646761924 742 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3204 9114183 49.47 µM 1.011499382939 0.137133627745613 no 502 0.155888738155533 747 17027248 SGTC_2608 thymoquinone 42.66 µM 1.00774948516772 0.137987342546621 no 503 0.156787371036066 745 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1454 4239-0054 42.6 µM 1.00662036654982 0.138245110210109 no 504 0.157058621700214 857 1340767 SGTC_672 1441-0018 53.7 µM 1.00417221841635 0.138805127418788 no 505 0.157647805253678 749 251141 SGTC_2420 aureobasidin a 50 nM 1.00332871181288 0.138998438070573 no 506 0.157851143676715 844 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3062 9077494 49.47 µM 1.00264573676083 0.139155093117315 no 507 0.158015909977786 771 16459633 SGTC_3290 9121031 71.43 µM 1.00060838002272 0.139623118449831 no 508 0.158508088556433 723 17014854 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.994633156860711 0.141001925526149 no 509 0.159957357579533 767 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2563 tomatine 8.54 µM 0.993011480121991 0.14137772195048 no 510 0.160352179955213 847 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1759 st043059 70 µM 0.992634780581379 0.141465112827718 no 511 0.160443984378261 813 669426 SGTC_1636 st007707 68.9 µM 0.992250765789544 0.141554238449275 no 512 0.160537606922331 835 403051 SGTC_3153 9100258 49.47 µM 0.991315358992336 0.141771495282507 no 513 0.160765807771064 732 25236848 SGTC_500 h-89 112 µM 0.990904843268622 0.141866912600502 no 514 0.160866023593263 870 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_447 ml7 120 µM 0.989720584812824 0.142142416732607 no 515 0.16115535533118 825 4216 Selective myosin light chain kinase inhibitor. SGTC_2118 5526350 200 µM 0.98916089245242 0.142272748657432 no 516 0.161292214475769 837 743594 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.988529165444789 0.142419951933174 no 517 0.161446778989173 871 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_579 4491-1009 110 µM 0.988333423968476 0.142465583968685 no 518 0.161494690608264 1022 1271041 SGTC_2595 hexamethylquercetagetin 100 µM 0.987825814252425 0.142583966046218 no 519 0.161618981370382 749 386331 SGTC_2965 9082772 38.63 µM 0.98773708842424 0.142604665046689 no 520 0.161640712730885 842 16459634 SGTC_2153 5569715 200 µM 0.986153118881747 0.142974533955005 no 521 0.162028990308178 803 2054701 SGTC_160 3453-0671 289.699 µM 0.984475048470642 0.143367082693766 no 522 0.162440996916609 883 5322268 SGTC_3001 9076041 71.4286 µM 0.982299293363412 0.143877136714772 no 523 0.162976211285064 800 16004211 SGTC_1961 st076550 68.7 µM 0.981563744982812 0.14404984506202 no 524 0.163157407957408 757 1579337 SGTC_1333 1482-0047 286 µM 0.981469341446437 0.144072021335125 no 525 0.163180673016809 861 3811116 SGTC_734 2023-0417 80 µM 0.981376402307028 0.144093855856487 no 526 0.163203579292119 806 3935732 SGTC_1913 st060213 96.1 µM 0.980686831234965 0.144255928926579 no 527 0.163373599911318 848 688959 SGTC_687 k029-0044 34.9 µM 0.980665484434717 0.144260948123697 no 528 0.163378865013013 883 5829338 SGTC_1617 st002906 78 µM 0.976036643375865 0.145352091908133 no 529 0.164523152947117 849 5150859 SGTC_999 SEC7.066 22.7 µM 0.974765751646893 0.145652644571352 no 530 0.164838234592625 887 740511 YDR170C SEC7 SGTC_2667 digitoxin 100 µM 0.974142355255551 0.145800223964361 no 531 0.164992930869953 791 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3237 9133362 49.47 µM 0.971753940280752 0.146366573973023 no 532 0.165586487507627 838 43845137 SGTC_2233 sulbentine 40.3845 µM 0.970155459394988 0.146746435822488 no 533 0.165984504204741 884 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_111 0083-0039 52.457 µM 0.969228425936347 0.146967038153667 no 534 0.166215615615336 730 759313 SGTC_3205 9113483 49.47 µM 0.968237248127569 0.147203150553112 no 535 0.166462948156419 830 17018033 SGTC_883 0850-0245 24.6 µM 0.967182944401601 0.147454579372033 no 536 0.166726293404407 864 6823229 YPR165W RHO1 SGTC_1300 1094-0077 113 µM 0.958233045550469 0.149600523459533 no 537 0.168972628656305 794 5532636 SGTC_1972 st070201 17.4 µM 0.953867304936521 0.150654835081407 no 538 0.170075407565976 857 2829099 SGTC_2435 5706476 10.6 µM 0.953454658721955 0.150754743074706 no 539 0.170179879392722 901 5725375 SGTC_2857 9024691 58.44 µM 0.953296397598448 0.150793072227144 no 540 0.17021995810659 806 16478292 SGTC_1843 st055809 45.5 µM 0.952696105666616 0.150938515488293 no 541 0.170372033533516 802 16413835 SGTC_186 3455-3465 67.277 µM 0.951282930037187 0.151281278865906 no 542 0.170730384947528 796 755278 SGTC_1753 st043925 64 µM 0.950320745384315 0.151514951166931 no 543 0.17097465045398 882 670181 SGTC_1001 4048-4355 44.4 µM 0.95030238519913 0.151519412379684 no 544 0.170979313644631 835 21824233 SGTC_2495 cafestol 54.53 µM 0.950260682683169 0.151529545706285 no 545 0.170989905712764 786 16667697 An anti-infammatory. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.950126546991118 0.151562142496991 no 546 0.171023977831883 915 91467 include heat shock SGTC_1892 st058411 7.36 µM 0.948359087179909 0.151992094553739 no 547 0.171473339990013 919 3934738 SGTC_3009 9080819 71.4286 µM 0.947210812373209 0.152271857466791 no 548 0.171765683417465 857 17027216 SGTC_1222 0366-0074 1.18 µM 0.943487228387474 0.15318141284529 no 549 0.172715872444562 924 286520 SGTC_2274 7947094 46.08 µM 0.942170047831214 0.153504019274222 no 550 0.173052793055693 932 2971028 SGTC_899 1083-0020 478 µM 0.934870840799242 0.155299906024881 no 551 0.17492743299108 885 767123 SGTC_3040 9091894 49.47 µM 0.93245021724443 0.155898522453684 no 552 0.175551951456208 791 25236966 SGTC_1571 st070080 73.4 µM 0.927029530123468 0.157244559975344 no 553 0.176955601147632 882 4315245 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.924850957466796 0.157787678342787 no 554 0.177521719957581 868 616764 SGTC_2934 9036370 36.88 µM 0.922672485044554 0.15833200227161 no 555 0.178088954438812 910 6462800 SGTC_372 0155-0182 15.9 µM 0.921656115992838 0.158586378264862 no 556 0.178353988874581 942 771486 SGTC_1172 0370-0043 85 µM 0.920358528360307 0.15891152668022 no 557 0.178692716515274 895 376585 SGTC_1081 sertraline 6 µM 0.919974822021619 0.159007759129133 no 558 0.178792958351409 924 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2265 7929201 200 µM 0.919079129414263 0.159232544833217 no 559 0.179027092401287 939 1265108 SGTC_153 4077-0274 519.67 µM 0.918677957925638 0.159333291483863 no 560 0.179132021153036 848 3121976 SGTC_103 0844-0104 51.839 µM 0.917153053614689 0.159716623210462 no 561 0.179531221715665 980 5375804 SGTC_116 0155-0182 31.788 µM 0.91566720634022 0.160090716711294 no 562 0.179920735063014 961 771486 SGTC_110 0850-0284 111.64 µM 0.914667718081478 0.16034268107523 no 563 0.18018304824076 756 3906265 SGTC_1662 st014054 52 µM 0.914263502086001 0.160444654806016 no 564 0.18028920184768 868 2838777 SGTC_2951 9072950 58.06 µM 0.91313230961772 0.160730251941763 no 565 0.180586479679844 994 16488155 SGTC_1252 0493-0875 34.8 µM 0.912620787808907 0.160859507034118 no 566 0.180721008693385 857 3960963 SGTC_328 k915-0120 63.5 µM 0.912099066805883 0.160991409215961 no 567 0.180858284778038 899 6624543 SGTC_764 1951-2361 146 µM 0.911425751336163 0.161161742016435 no 568 0.181035545222653 851 5438930 SGTC_433 pimozide 108 µM 0.911120340758385 0.16123904237813 no 569 0.181115985033378 779 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1609 st001574 46.4 µM 0.910623063488595 0.161364956536497 no 570 0.181247007078657 917 3960012 SGTC_485 niflumic acid 177 µM 0.90975255930828 0.161585528761018 no 571 0.181476509389106 866 4488 A COX2 inhibitor. SGTC_2298 7976326 193.81 µM 0.909421203189455 0.161669540873194 no 572 0.181563916881424 830 2235818 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.909200133513979 0.161725606763908 no 573 0.181622246875904 837 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_76 0433-0009 400.328 µM 0.906953282445911 0.162296153602206 no 574 0.18221575135786 803 2841569 SGTC_2269 7935389 174.42 µM 0.906455394261513 0.162422760358318 no 575 0.182347432131077 860 97605 SGTC_1195 1502-0147 41.1 µM 0.905638151427 0.162630714327074 no 576 0.182563704236519 939 817940 SGTC_2171 5739187 198.077 µM 0.90487070652847 0.162826154442168 no 577 0.182766943791116 864 2262761 SGTC_1825 st052143 62.6 µM 0.904818423716893 0.162839474514667 no 578 0.182780794789144 879 674173 SGTC_2888 9058547 12.99 µM 0.904457266363223 0.162931505792247 no 579 0.182876492118971 809 16476514 SGTC_1727 st034309 9.9045 µM 0.904421221987384 0.162940692591511 no 580 0.182886044659424 974 870305 SGTC_1525 8-methoxypsoralen 92.5 µM 0.903981510865616 0.163052790942005 no 581 0.183002602703304 976 4114 Related to psoralen; DNA damaging agent. SGTC_571 k831-0106 44.2 µM 0.903761122029192 0.163108994923282 no 582 0.183061040519194 862 4783639 SGTC_358 0075-0058 9.45 µM 0.90319303136308 0.163253928540738 no 583 0.183211727857016 966 1069125 SGTC_904 1141-0088 396 µM 0.902541509913043 0.163420250342247 no 584 0.183384640606569 875 1378119 SGTC_2081 5214970 32.255 µM 0.901538813122897 0.163676435901011 no 585 0.183650953436942 937 2063512 SGTC_3318 9139014 38.6185 µM 0.900914819679223 0.163835995607524 no 586 0.183816805538679 877 16643984 SGTC_3251 9135047 49.47 µM 0.894233933005687 0.165550671076899 no 587 0.185598370088996 903 17682963 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.891821320353275 0.166172719750874 no 588 0.186244356051774 960 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2863 9028737 58.44 µM 0.891767738497843 0.166186551982808 no 589 0.186258718588757 937 6460917 SGTC_2932 9016711 44.54 µM 0.89053637641736 0.166504634780315 no 590 0.18658897246387 973 7117328 SGTC_2704 st078022 71.1 µM 0.890320429575926 0.166560458181904 no 591 0.186646927204322 931 54697681 SGTC_1187 1391-0724 117 µM 0.888996492911231 0.166902966846518 no 592 0.187002482315541 932 6997986 SGTC_1699 st031318 29.054 µM 0.888252056952635 0.167095755344924 no 593 0.187202591219874 969 5340658 SGTC_475 α-linolenic acid 10 µM 0.887923684056376 0.167180840538206 no 594 0.187290901919554 980 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2405 ticlatone 3.52 µM 0.886736741272977 0.167488623955344 no 595 0.187610326180863 965 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_728 3030-5151 22.5 µM 0.886446766886723 0.167563872002407 no 596 0.187688413805791 893 3125388 SGTC_2035 5154463 94.595 µM 0.885179056673883 0.167893097131122 no 597 0.188030033039516 913 2769623 SGTC_2926 9010726 65.15 µM 0.883433773579799 0.168347029005332 no 598 0.188500974865302 905 2994293 SGTC_2297 7971671 152.32 µM 0.882550474739854 0.168577067358136 no 599 0.188739598484228 922 909016 SGTC_765 1319-0117 244 µM 0.880527992724596 0.169104544909917 no 600 0.189286673796347 927 3487746 YGL099W LSG1 SGTC_3233 9132340 49.47 µM 0.879521573547426 0.169367420621141 no 601 0.18955927054412 903 17682950 SGTC_1165 k072-0275 30.3 µM 0.879316043017221 0.169421137229246 no 602 0.189614969830477 945 6153523 YGL055W OLE1 SGTC_570 0987-0065 62.6 µM 0.877685756294996 0.169847609471758 no 603 0.190057138187462 832 3104428 SGTC_1697 st025554 27.742 µM 0.877581496489212 0.169874906546773 no 604 0.190085437202284 909 1269519 SGTC_1113 artemisinin 1.17947 µM 0.876092629078081 0.170265025426673 no 605 0.190489839759759 970 2240 An anti-malaria and mitochondrial poison. SGTC_1558 st069300 45.6 µM 0.875853701161657 0.17032768365995 no 606 0.190554785936372 874 24208000 SGTC_558 k064-0027 21.3 µM 0.874839177535808 0.170593904368627 no 607 0.190830708486124 950 5088526 SGTC_3354 9151612 71.43 µM 0.873160940625634 0.171034874285116 no 608 0.191287680637235 976 27261949 SGTC_2012 4023501 200 µM 0.872028880739457 0.171332743327343 no 609 0.191596311108483 866 3477460 SGTC_2165 5727197 32.143 µM 0.871297436670576 0.171525378072748 no 610 0.191795884867423 891 1361712 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.870939328001828 0.171619740820179 no 611 0.191893640843351 1008 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3179 9107801 49.47 µM 0.870507678637919 0.171733525843087 no 612 0.192011512379692 951 4818259 SGTC_225 nsc-122657 1.016 µM 0.86852213475875 0.172257546002318 no 613 0.192554280117929 826 275685 SGTC_1284 0929-0043 16 µM 0.868476112391688 0.172269704204846 no 614 0.192566871890394 948 1239883 SGTC_3171 9103192 49.47 µM 0.868349409877646 0.172303179341049 no 615 0.192601540443808 998 13018434 SGTC_176 1486-1328 72.834 µM 0.867850815602198 0.172434949550365 no 616 0.192738003680645 981 22310231 SGTC_1990 st072050 59.8 µM 0.866462042306988 0.172802318077614 no 617 0.193118416650639 964 17233948 SGTC_1004 4084-0029 199 µM 0.866074797733936 0.172904843735502 no 618 0.193224572409906 1002 716894 YLR208W SEC13 SGTC_2211 7117706 200 µM 0.863266820249462 0.173649434247658 no 619 0.193995391210067 934 822771 SGTC_2195 6536160 144.242 µM 0.860218756441851 0.174459993950429 no 620 0.194834233656379 900 3834386 SGTC_2011 4012611 177 µM 0.85967133266057 0.17460582238083 no 621 0.194985120769718 959 2049887 SGTC_606 k015-0008 38.6 µM 0.857214555417383 0.175261237018717 no 622 0.195663159874433 1040 1970475 SGTC_3117 9124945 49.47 µM 0.856784170396297 0.175376214751987 no 623 0.195782087808866 857 17592065 SGTC_1583 clindamycin 39.6 µM 0.854586534820343 0.175964060292892 no 624 0.196390042297393 859 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2767 sibutramine 71.45 µM 0.854098606069176 0.176094745423168 no 625 0.196525178103475 966 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1511 0906-3109 28.5 µM 0.84999598126551 0.177196007228132 no 626 0.19766366027205 1071 2882180 SGTC_3021 9087658 49.47 µM 0.849384443330306 0.177360533232007 no 627 0.197833703336207 979 25237042 SGTC_2524 avocatin b 10.57 µM 0.847048964667915 0.177989749316511 no 628 0.198483914877615 948 6710748 SGTC_3112 9123419 49.47 µM 0.845946399057947 0.178287286994444 no 629 0.19879132335409 1041 17015854 SGTC_2675 theaflavin digallate 100 µM 0.843402872468892 0.178974876241665 no 630 0.199501582989839 991 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2605 digitonin 300 nM 0.842802496618774 0.179137418406788 no 631 0.199669455742885 1071 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3188 9110789 49.47 µM 0.842478399563676 0.179225201085795 no 632 0.199760112731332 981 849217 SGTC_1748 st037455 53.6035 µM 0.841884119272214 0.17938623399352 no 633 0.199926410156807 955 580690 SGTC_474 dl-dihydrosphingosine 5 µM 0.841273608598206 0.179551759566709 no 634 0.200097335991572 1017 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3346 9158254 43.5805 µM 0.841232267453357 0.179562971712522 no 635 0.200108913525169 965 17639500 SGTC_2286 7945697 125 µM 0.841086920176972 0.179602394889335 no 636 0.200149621036292 990 1245733 SGTC_457 grayanotoxin iii 135 µM 0.840472908445705 0.179768995992175 no 637 0.200321642638696 996 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1682 st012968 530 nM 0.840079031436355 0.179875918572784 no 638 0.20043203802184 900 24207270 SGTC_1724 st037281 8.293 µM 0.838475274965233 0.180311689568643 no 639 0.200881914168883 966 574124 YDL195W SEC31 SGTC_2038 4100038 30.985 µM 0.838320378854928 0.180353812827229 no 640 0.200925396759597 949 3596803 SGTC_2203 7227154 166.4 µM 0.838058788681529 0.180424965045029 no 641 0.20099884343456 1015 896304 SGTC_975 1335-0046 28.5 µM 0.836308063519298 0.1809016134336 no 642 0.201490809009116 1003 16486740 SGTC_936 3005-4620 401 µM 0.834097224894802 0.181504657663378 no 643 0.202113099410717 1027 777207 SGTC_164 4100-3994 89.624 µM 0.833186918786183 0.181753324589796 no 644 0.202369659481259 1052 4615967 SGTC_1198 1612-1005 86.7 µM 0.832646400276456 0.181901078003436 no 645 0.202522090973554 1026 6998509 SGTC_2448 5185112 27.17 µM 0.83245215541514 0.181954194142565 no 646 0.20257688668054 911 5718189 SGTC_2691 st077356 60.2 µM 0.831630924672068 0.182178866360159 no 647 0.202808650542555 1024 2839272 SGTC_2995 9067767 71.4286 µM 0.831336611631484 0.182259426678849 no 648 0.202891748722705 933 11673567 SGTC_723 4182-0001 115 µM 0.829968249022402 0.182634271630686 no 649 0.203278367772506 952 744821 YLR208W SEC13 SGTC_2523 spermine 47.74 µM 0.828698066377772 0.182982651972081 no 650 0.203637640104683 990 1103 A DNA binding polyamine. SGTC_2815 7968870 71.43 µM 0.827830308167686 0.183220895285465 no 651 0.203883303869432 1009 2977326 YHR190W ERG9 SGTC_3056 9094900 49.47 µM 0.822983635764863 0.18455510585069 no 652 0.205258649664934 993 25236784 SGTC_1603 st002045 67.8 µM 0.821861374030482 0.184864905771597 no 653 0.205577899313869 1026 5887985 SGTC_847 0342-0274 5.54 µM 0.821025218524777 0.18509593615975 no 654 0.205815951881152 1050 18097 SGTC_1053 3366-3204 134 µM 0.81896921001837 0.185664775103082 no 655 0.206401990363707 1027 3632071 YPR165W RHO1 SGTC_3123 9126162 49.47 µM 0.818524210119915 0.185788036522914 no 656 0.206528961835596 1057 25239884 SGTC_3297 9117502 71.43 µM 0.8183402081811 0.185839018420881 no 657 0.206581476482558 1022 7453720 SGTC_2508 celastrol 40.54 µM 0.817626568133496 0.186036830605201 no 658 0.206785226074287 973 122724 Celastrol is a natural product and antioxidant. SGTC_2391 6285546 200 µM 0.817502523817054 0.186071227465395 no 659 0.20682065379078 1036 846083 SGTC_425 3825-7017 13.1 µM 0.817178509886845 0.186161093482528 no 660 0.206913210841084 1025 3397440 SGTC_2991 9074669 71.4286 µM 0.814729265669122 0.186841266942245 no 661 0.207613648791704 1032 17333109 SGTC_487 nimodipine 119 µM 0.813422532890508 0.187204784774029 no 662 0.207987922322783 940 4497 L-type voltage-gated calcium channels inhibitor SGTC_1161 k007-0610 110 µM 0.813020837716307 0.187316619520335 no 663 0.208103055582501 1091 5843850 SGTC_1010 4112-3296 15.2 µM 0.810509154260495 0.188016825943119 no 664 0.208823802946803 1066 704384 SGTC_3181 9108277 49.47 µM 0.810416356557954 0.18804272697453 no 665 0.208850460123534 1021 17097298 SGTC_1673 st016611 27.3 µM 0.809988893288501 0.188162065904717 no 666 0.208973279609391 1041 5226799 SGTC_1405 3909-7894 12 µM 0.80946712234316 0.188307796920923 no 667 0.209123253381938 1042 7104060 SGTC_2959 9079155 11 µM 0.80934611266777 0.188341604958487 no 668 0.209158044510735 994 16189457 SGTC_724 3910-0327 137 µM 0.809057319969918 0.188422303837896 no 669 0.209241088202741 1044 2885483 SGTC_3343 9148379 18.9835 µM 0.808328925648279 0.188625937645857 no 670 0.209450627590035 1065 1955036 SGTC_3265 9137266 49.47 µM 0.807961705428953 0.188728651115105 no 671 0.209556313730208 1006 17224265 SGTC_27 0485-0001 32.618 µM 0.807371000176288 0.18889394686164 no 672 0.209726384757868 971 2054479 SGTC_1029 k015-0030 64.7 µM 0.805951737215704 0.189291460560003 no 673 0.210135338941624 1006 2208316 SGTC_1945 st075991 56.6 µM 0.805858824086557 0.189317502044714 no 674 0.210162127765136 973 1084980 SGTC_946 3434-1334 87.4 µM 0.805747385958451 0.189348738583466 no 675 0.210194260383949 999 4047976 SGTC_464 bw-b 70c 158 µM 0.805289092327092 0.189477233410399 no 676 0.210326437358657 1057 5353454 SGTC_2205 7238770 200 µM 0.802880893831301 0.190153317419308 no 677 0.211021790113816 1054 279867 SGTC_1958 st076513 41.9 µM 0.802533435093444 0.190250986122974 no 678 0.211122227849196 1051 732122 YGL099W LSG1 SGTC_2841 9004761 38.96 µM 0.802176724117508 0.190351287633025 no 679 0.211225369210866 1004 2991039 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.798576388980895 0.191365462511951 no 680 0.212268041463286 1037 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1786 berberine 21.6 µM 0.79791345744187 0.191552563414034 no 681 0.21246035666603 989 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3253 9135987 49.47 µM 0.793972568152042 0.192667122484348 no 682 0.213605700628452 990 4182430 SGTC_348 k064-0012 10.7 µM 0.793722474936436 0.192737987120475 no 683 0.213678506618514 999 5066323 SGTC_2340 7987427 183.45 µM 0.792683125632623 0.193032660335289 no 684 0.213981232052375 990 2239331 SGTC_2955 9076254 12.21 µM 0.791165781254976 0.19346334693237 no 685 0.214423628414409 1017 16459619 SGTC_1464 k208-0027 110 µM 0.790095220208344 0.193767569912861 no 686 0.214736080548717 1049 X1464 SGTC_1732 st034308 51.822 µM 0.789501143968324 0.193936515225141 no 687 0.214909580711632 987 830119 SGTC_2739 tacrine 100.86 µM 0.787331456162872 0.194554300250501 no 688 0.215543930062445 1060 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2846 9008642 19.48 µM 0.782962975185859 0.195801785482593 no 689 0.216824427253272 1014 2992898 SGTC_839 0122-0028 230 µM 0.782155062165885 0.196033027947463 no 690 0.217061725209685 1075 759448 SGTC_2115 tiliquinol 12.7705 µM 0.781051890103266 0.196349047441389 no 691 0.217385988059683 1037 71208 A bioactive hydroxyquinoline. SGTC_2346 9031566 143.75 µM 0.77956579695561 0.19677524805213 no 692 0.217823247363613 1054 4771086 SGTC_2602 kawain 100 µM 0.777199647610694 0.197454997369709 no 693 0.218520495049435 1104 5369129 SGTC_3139 9095020 49.47 µM 0.775100530843453 0.198059220322012 no 694 0.2191401289753 900 25236292 SGTC_3004 9076122 71.4286 µM 0.773747883348982 0.198449165748651 no 695 0.219539948824238 1070 44782551 SGTC_1319 1306-0155 43.7 µM 0.77345194340328 0.198534541953169 no 696 0.219627479525198 1098 3122360 SGTC_2406 ethylparaben 405.7 µM 0.773351132729924 0.198563630049614 no 697 0.219657301058708 977 8434 A possible steroid mimic. SGTC_3090 9117696 49.47 µM 0.772263595490324 0.198877593460465 no 698 0.219979161114465 1066 7923821 SGTC_2740 felodipine 17.08 µM 0.771653250193178 0.199053926340593 no 699 0.22015991320288 1031 3333 L-type calcium channel blocker SGTC_280 3448-3607 3.04 µM 0.770999800341041 0.199242816794687 no 700 0.220353524968932 1069 626179 SGTC_2453 5731132 22.18 µM 0.770124780103647 0.199495924819861 no 701 0.22061293899635 1112 1362040 SGTC_2617 dihydrotanshinone i 20.83 µM 0.769952640606889 0.199545740598642 no 702 0.22066399314636 1123 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_315 k915-0449 187 µM 0.769220129048998 0.199757807221496 no 703 0.220881321416325 1111 20970215 YNL149C PGA2 SGTC_3128 9127691 49.47 µM 0.7683954099326 0.199996730682607 no 704 0.221126153260693 976 41316314 SGTC_2591 skatole 100 µM 0.76663397657795 0.200507597933978 no 705 0.221649584238531 1078 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1055 3448-0672 86 µM 0.764044894113232 0.201259928623443 no 706 0.222420244751851 1046 748378 SGTC_596 1155-0152 116 µM 0.763719313481895 0.201354654873054 no 707 0.222517264415598 1105 280313 SGTC_132 0417-1715 25.805 µM 0.762376688571218 0.201745567916636 no 708 0.22291760761385 1115 6769098 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.761455467090205 0.202014049622145 no 709 0.223192534139722 1084 6708760 SGTC_2288 7946289 167.31 µM 0.760897814207766 0.202176676387137 no 710 0.223359052107227 1135 1246052 SGTC_2906 7926292 26.41 µM 0.760578963552225 0.202269697106362 no 711 0.223454294281005 1097 2966319 SGTC_1929 genistein trimethyl ether 50.5 µM 0.76027065792516 0.202359665784518 no 712 0.223546408572544 1137 136420 SGTC_1815 st051655 58.2 µM 0.760119279690151 0.202403849214508 no 713 0.223591644645535 1075 5984156 SGTC_607 4491-0986 66.8 µM 0.759608385330167 0.202553008777092 no 714 0.223744352672406 1119 698981 YDR232W HEM1 SGTC_3235 9132602 49.47 µM 0.759299971289163 0.202643084441118 no 715 0.223836567349903 1142 4912240 SGTC_314 1671-0008 2.74 µM 0.75738489608151 0.203202938568947 no 716 0.224409651149002 1061 3913060 SGTC_2940 9060638 45.86 µM 0.755219994249344 0.203836937634935 no 717 0.225058496879613 1075 4027022 SGTC_3264 9137442 49.47 µM 0.754467943398678 0.204057453981232 no 718 0.225284143622149 1079 17015726 SGTC_2431 5490079 200 µM 0.754250485560435 0.204121243445876 no 719 0.225349413950173 1159 5722345 SGTC_2103 5378138 10 µM 0.753743744467083 0.204269937850717 no 720 0.225501554664783 1165 244142 SGTC_2085 5307070 144.047 µM 0.75351667466427 0.20433658847544 no 721 0.225569747512767 1071 2840351 SGTC_459 nigericin 15.3 µM 0.753348209103216 0.204386045665328 no 722 0.225620348069937 1173 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_458 nppb 133 µM 0.753111843659898 0.204455448539505 no 723 0.225691353959519 1094 4549 A chloride channel blocker. SGTC_663 1486-0733 13.9 µM 0.752930107617566 0.204508820376801 no 724 0.225745957377917 1088 722445 YPR165W RHO1 SGTC_3269 9137823 49.47 µM 0.752692249280927 0.204578686610947 no 725 0.225817434283796 1027 17682936 SGTC_2843 9000894 45.46 µM 0.752291417548263 0.204696455219775 no 726 0.225937913975381 1001 2242070 SGTC_1736 st036774 51 µM 0.749805271211196 0.205427811692458 no 727 0.226685996786229 1148 1272247 SGTC_1770 st043884 66.3 µM 0.749525177653434 0.205510304731755 no 728 0.226770364616686 1131 670149 SGTC_620 0109-0052 432 µM 0.748762663666016 0.205734979672885 no 729 0.22700013351221 1131 493037 SGTC_2077 5212015 200 µM 0.746561136039472 0.20638447780042 no 730 0.22766425758828 1062 780900 SGTC_1632 st005650 90 µM 0.744665461080755 0.206944715123411 no 731 0.228236991961765 1098 2759605 SGTC_3175 9106517 49.47 µM 0.743694489264018 0.20723201898515 no 732 0.228530662045897 1106 41468073 SGTC_1417 3966-0327 90.4 µM 0.743619525612556 0.207254210017069 no 733 0.228553343598722 1154 651118 SGTC_984 1492-0255 2.91 µM 0.743296674098559 0.207349797836448 no 734 0.228651042371737 1059 1585198 SGTC_2374 9071832 200 µM 0.741599066760956 0.207852843298141 no 735 0.229165144574086 1095 17381698 SGTC_56 0957-0365 83.25 µM 0.738785420396469 0.20868818568392 no 736 0.230018653157291 1115 6752360 SGTC_3272 9137413 49.47 µM 0.738772203398324 0.208692114336969 no 737 0.230022666675197 1116 17614870 SGTC_689 0833-0039 98 µM 0.738226298809817 0.208854418439462 no 738 0.230188472123583 1148 5374726 SGTC_2812 7970281 58.44 µM 0.738171146314432 0.208870820085359 no 739 0.230205227091087 1139 2233435 SGTC_998 3996-0085 177 µM 0.7377473590376 0.208996874310691 no 740 0.230333993651756 1173 715391 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.736792692480329 0.209281001052036 no 741 0.230624213876033 1172 1377 SGTC_3026 9090633 49.47 µM 0.736320130769332 0.209421728396866 no 742 0.230767948991893 1142 25236842 SGTC_1352 1496-0991 99 µM 0.735691741075096 0.209608947031914 no 743 0.230959158474887 1139 3000039 SGTC_3081 9117243 49.47 µM 0.734493753583382 0.209966140793171 no 744 0.231323932883303 1134 45595589 SGTC_3039 9090270 49.47 µM 0.733989506117486 0.210116594881897 no 745 0.231477566895187 1150 17173750 SGTC_2337 9009472 200 µM 0.733373099575123 0.210300600271026 no 746 0.231665450763389 1131 5742383 SGTC_2291 7917025 104.35 µM 0.732227038844546 0.210642965733531 no 747 0.232015001723665 1109 2964612 SGTC_2311 7694451 200 µM 0.729709085404808 0.211396307472252 no 748 0.232784013215541 1092 2163142 SGTC_3142 9086498 49.47 µM 0.727654907418619 0.212012060239692 no 749 0.233412430051978 1087 25236367 SGTC_563 tetrahydrosecaminediol 614 µM 0.726599873704992 0.212328720517591 no 750 0.233735552815982 1187 334274 A psychoactive constituent of the cannabis plant. SGTC_654 1124-0271 80.9 µM 0.726461254022849 0.212370346685865 no 751 0.233778025970578 1137 5403748 SGTC_1752 st044819 83.042 µM 0.725671319669805 0.212607647434393 no 752 0.234020143961384 1118 441209 YML126C ERG13 SGTC_680 0417-1641 114 µM 0.724540912983044 0.212947497215453 no 753 0.23436685952705 1124 2835990 SGTC_1361 1608-0041 5.61 µM 0.72350205874207 0.213260101672604 no 754 0.234685744860808 1150 X1361 SGTC_1342 1486-1464 234 µM 0.721884076854677 0.213747505559608 no 755 0.235182875915406 1191 3253938 SGTC_1076 itraconazole 331 nM 0.721638604694251 0.213821508694584 no 756 0.235258348939104 1178 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_68 0986-0284 82.829 µM 0.719829057464741 0.214367497841537 no 757 0.235815125892574 1080 423278 YIL048W NEO1 SGTC_26 0302-0163 425.158 µM 0.71916042354956 0.214569447678625 no 758 0.236021040553451 1188 3100915 SGTC_2046 4110841 106 µM 0.715588830186652 0.215650060020785 no 759 0.237122636344363 1177 44119630 YMR134W ERG29 SGTC_2664 lyso-paf C-16 73.48 µM 0.715203403176394 0.215766862182923 no 760 0.237241683240315 1181 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3348 9149464 3.537 µM 0.714594059154716 0.215951596321974 no 761 0.237429958373157 1181 1951442 SGTC_1044 1222-0021 1.78 µM 0.713490708886141 0.216286330866469 no 762 0.237771080210452 1114 4306703 SGTC_12 0849-0099 9.267 µM 0.713378697972759 0.216320329538138 no 763 0.237805725550699 1119 6071388 SGTC_862 0452-0056 10.2 µM 0.712738638209017 0.21651466621209 no 764 0.238003751222762 1124 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3047 9092122 49.47 µM 0.712088795347186 0.216712076561845 no 765 0.23820489609158 1150 17173831 SGTC_1451 4152-0210 104 µM 0.711589790395934 0.216863735749699 no 766 0.238359415527968 1173 659563 SGTC_2999 9069765 71.4286 µM 0.711317826419224 0.216946417741831 no 767 0.238443653670973 1176 2097066 SGTC_1921 5740136 50 µM 0.710973797901806 0.217051034762153 no 768 0.238550236437594 1172 1774243 SGTC_951 1171-0579 82.7 µM 0.710729897475876 0.217125221083765 no 769 0.238625814521251 1189 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3177 9107506 49.47 µM 0.709744544901521 0.217425081361531 no 770 0.238931281753119 1126 8897194 SGTC_1490 4089-0339 670 nM 0.709642392280325 0.217456181889471 no 771 0.238962962116527 1132 742542 SGTC_1233 0325-0408 14.2 µM 0.707126519508305 0.218222953473503 no 772 0.239743928507596 1173 12874 SGTC_3064 1327-0027 10 µM 0.705001789187423 0.218871726896529 no 773 0.240404561360029 1075 16000455 YPR107C YTH1 SGTC_3034 9090421 49.47 µM 0.704575579283049 0.219002000982071 no 774 0.240537200190823 1125 17173761 SGTC_1616 st002734 56.1 µM 0.704105378699008 0.219145772856302 no 775 0.240683575375735 1157 4026101 SGTC_1927 st060202 13.8 µM 0.701144102139699 0.220052479987575 no 776 0.241606544925317 1162 688887 SGTC_1114 scopoletin 1.73284 µM 0.700255294719438 0.22032504141602 no 777 0.241883942566148 1208 5280460 A coumarin with genotoxic properties. SGTC_1814 st052110 31.539 µM 0.698802605977684 0.220770938942193 no 778 0.242337699863912 1169 674163 SGTC_1427 4048-4900 550 nM 0.697512406094072 0.221167394053116 no 779 0.242741089088434 1184 24132586 SGTC_1002 4049-0206 172 µM 0.697229094009783 0.221254505246 no 780 0.242829717062746 1229 4662749 SGTC_2561 acetosyringone 100 µM 0.696701653983079 0.221416731780619 no 781 0.242994761748502 1215 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2705 st078069 42.8 µM 0.695517632127361 0.221781153024115 no 782 0.243365482613363 1168 1530061 SGTC_3247 9135149 49.47 µM 0.69497073218442 0.221949594885615 no 783 0.243536821791521 1168 8934436 YOR116C RPO31 SGTC_90 0870-0863 4.608 µM 0.694005447908347 0.222247074762736 no 784 0.243839396203626 1199 1738164 SGTC_532 1548-0774 215 µM 0.691313626074354 0.223077837152177 no 785 0.244684235305891 1284 5932993 SGTC_183 3914-0051 30.55 µM 0.690043691004028 0.223470383425253 no 786 0.245083356046594 1191 1596232 SGTC_859 0439-0102 54.6 µM 0.689825644809465 0.223537822613635 no 787 0.245151919763365 1219 610143 SGTC_1136 pergolide 1.05886 µM 0.689307019640937 0.223698273935005 no 788 0.245315040721696 1178 47811 A dopamine receptor agonist. SGTC_1449 4112-4002 201 µM 0.688272812353559 0.224018430526692 no 789 0.245640499618154 1182 2059539 SGTC_800 3448-7362 155 µM 0.687810085900663 0.22416175967835 no 790 0.24578619193939 1290 15991913 SGTC_58 0957-0393 9 µM 0.687565112537995 0.224237661062105 no 791 0.245863342113011 1182 6997992 SGTC_753 1322-0200 289 µM 0.683823201815175 0.225398849233683 no 792 0.247043406837835 1247 5403907 SGTC_611 3453-1652 23.7 µM 0.682359799224548 0.225853896101853 no 793 0.247505734546104 1218 1560575 SGTC_2700 st077718 96.8 µM 0.682256797896104 0.225885944052415 no 794 0.247538292804319 1206 904970 SGTC_1115 galangin 695.678 nM 0.682043641872689 0.225952273826647 no 795 0.247605677734587 1261 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_554 4483-2211 187 µM 0.681002041493951 0.226276556795662 no 796 0.247935099333408 1204 747107 SGTC_102 gallobenzophenone 83.616 µM 0.679700371523284 0.226682176944944 no 797 0.248347100367247 1266 70837 SGTC_3116 9124943 49.47 µM 0.679516385320219 0.226739542923607 no 798 0.248405364603599 1141 41905195 YPL160W CDC60 SGTC_1491 4138-0063 26.5 µM 0.679381961012294 0.226781460929491 no 799 0.248447938323161 1197 23883227 SGTC_3250 9135583 49.47 µM 0.678650883459081 0.227009511957865 no 800 0.248679547032487 1231 7699353 SGTC_2148 5546263 113.568 µM 0.677485767971137 0.227373223131058 no 801 0.249048898472018 1209 792097 SGTC_298 1391-0729 10 µM 0.677468872621009 0.227378499723741 no 802 0.249054256586572 1206 3237558 SGTC_1633 st005664 67.9 µM 0.674490759476595 0.228309672400747 no 803 0.249999679274407 1241 2063822 SGTC_2260 7964312 200 µM 0.67346682837066 0.228630321464105 no 804 0.250325172698707 1268 231951 SGTC_3245 9134821 49.47 µM 0.672679541171373 0.228877036210433 no 805 0.250575593024116 1203 17014901 SGTC_2963 9082507 9 µM 0.672405367360156 0.228962990013496 no 806 0.250662833381813 1240 16459611 SGTC_2322 7413319 38.22 µM 0.672375545158297 0.228972340399942 no 807 0.250672323586194 1256 1840400 SGTC_1999 st074831 12.5 µM 0.671987086567133 0.229094156407907 no 808 0.25079595864849 1219 17112523 SGTC_560 2332-1943 155 µM 0.671520135329901 0.229240634879872 no 809 0.250944618354256 1231 21177716 SGTC_2976 9009005 19.48 µM 0.671471169491568 0.229255998071728 no 810 0.250960209936038 1257 2993148 SGTC_537 1334-0398 209 µM 0.670982548035501 0.229409336270512 no 811 0.251115823656336 1226 5846986 SGTC_2402 5553605 200 µM 0.670287785678978 0.22962746413311 no 812 0.251337175955526 1270 6758546 SGTC_2490 carminic acid 95.39 µM 0.669462244968083 0.22988680219478 no 813 0.251600328468636 1193 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2466 5983409 37.09 µM 0.668353250738007 0.230235443203254 no 814 0.25195406466787 1226 2879657 SGTC_1018 4259-0013 28.1 µM 0.667528014087414 0.230495069471555 no 815 0.252217460851748 1239 6801262 SGTC_2463 5473429 200 µM 0.665701000763861 0.231070444725424 no 816 0.252801116863141 1220 5399405 SGTC_618 k072-0232 33.2 µM 0.665154786313131 0.231242617757235 no 817 0.2529757480043 1228 5872756 YGL099W LSG1 SGTC_3328 9140624 29.0385 µM 0.664034664955931 0.231595916566025 no 818 0.253334062355107 1247 4904392 SGTC_1216 1165-0504 9.65 µM 0.663686109234599 0.231705916285156 no 819 0.253445615851448 1239 6304004 SGTC_2461 5755302 26.15 µM 0.663644182641572 0.231719149741877 no 820 0.25345903598466 1253 2788904 SGTC_1902 st060212 70.5 µM 0.661896704639273 0.232271087565153 no 821 0.25401871193207 1268 688944 SGTC_1155 4088-0394 48.2 µM 0.66092575616273 0.232578075770259 no 822 0.254329963797612 1223 2326248 SGTC_535 2293-4129 48.2 µM 0.659803303284613 0.232933246604332 no 823 0.254690031624045 1276 396118 YIL048W NEO1 SGTC_490 phenamil 164 µM 0.65800184203687 0.233503901110567 no 824 0.25526847375517 1194 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2426 5582046 32.21 µM 0.657543415274487 0.233649242057077 no 825 0.255415782338402 1266 2251934 SGTC_659 k018-0002 107 µM 0.657465114895497 0.233674071649799 no 826 0.255440947435044 1242 6797879 YHR007C ERG11 SGTC_2657 nystatin 74.44 µM 0.65728744569304 0.233730417210085 no 827 0.255498053657603 1264 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2545 solidagenone 89.61 µM 0.657171409154992 0.233767220808659 no 828 0.255535353583166 1103 6708572 An anti ulcer agent SGTC_1524 corynanthine 62.1 µM 0.656691270862634 0.233919541607878 no 829 0.255689724188589 1300 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2341 7987486 176.74 µM 0.656260335570699 0.234056299882745 no 830 0.255828316854021 1259 1258686 SGTC_896 0964-0007 44.5 µM 0.655903618433443 0.234169538352128 no 831 0.255943069948832 1241 6756758 SGTC_1318 1280-3875 124 µM 0.655432277273175 0.234319210282226 no 832 0.256094737869166 1254 373245 SGTC_1374 2889-5571 141 µM 0.655408123373317 0.234326881653213 no 833 0.256102511361282 1262 2853281 SGTC_23 0213-0011 39.996 µM 0.654909740707928 0.234485200914543 no 834 0.256262934194033 1288 627608 SGTC_287 k060-0039 29.6 µM 0.654545095719263 0.234601073732014 no 835 0.256380341802578 1291 5861974 SGTC_1574 spiramycin 23.7 µM 0.652315432836657 0.235310279527543 no 836 0.257098853131075 1254 6419898 An antibiotic and protein synthesis inhibitor. SGTC_828 2074-0507 139 µM 0.652221381507476 0.235340221140676 no 837 0.257129184277441 1317 X828 SGTC_2397 5161689 200 µM 0.648360126541874 0.236571280799067 no 838 0.258376026741976 1335 2259942 SGTC_3316 9136639 10.545 µM 0.648220612234246 0.236615827497313 no 839 0.25842113604156 1307 4903665 SGTC_2119 5528445 120.635 µM 0.647476163864649 0.23685360668233 no 840 0.258661908224417 1292 791935 SGTC_2515 chrysin 20.77 µM 0.647084701864616 0.236978693581597 no 841 0.258788562854253 1267 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_848 0368-0089 85.6 µM 0.646804505542109 0.237068249184473 no 842 0.258879238001952 1248 762535 SGTC_438 sphingosine 6.67 µM 0.646413234188682 0.237193337404671 no 843 0.25900588596153 1148 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1259 0671-0132 43 µM 0.646183982340227 0.237266645341218 no 844 0.25908010581595 1240 X1259 SGTC_791 1348-1292 225 µM 0.645858077741535 0.237370881374335 no 845 0.259185635742332 1280 5437054 SGTC_136 0097-0015 404.482 µM 0.644249991670422 0.23788557317503 no 846 0.25970666907875 1281 4861337 SGTC_2807 7945238 51.95 µM 0.644086116942292 0.237938058049268 no 847 0.259759796197463 1307 17148797 SGTC_2801 7907800 81.82 µM 0.644005564071978 0.237963859395724 no 848 0.259785912968782 1294 6620925 SGTC_1909 st060837 51.5 µM 0.642052609166351 0.238589866355839 no 849 0.26041951244339 1248 678937 SGTC_981 1488-1094 54.9 µM 0.641707258100606 0.238700660099901 no 850 0.260531637858299 1249 3449522 SGTC_2737 bleomycin 30.5 nM 0.640763260689437 0.239003652062226 no 851 0.260838253057845 1306 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_772 k072-0172 35.3 µM 0.640205251475398 0.239182853407622 no 852 0.261019584566007 1206 5861980 SGTC_1995 st072814 61.1 µM 0.639301286109721 0.239473312268695 no 853 0.261313475983708 1231 5769371 SGTC_3076 9116187 49.47 µM 0.636436875932503 0.240394964913238 no 854 0.262245856040566 1261 27241210 SGTC_609 0986-0026 86.3 µM 0.636370659162093 0.240416293646669 no 855 0.262267430072137 1301 2848610 SGTC_1206 3978-0017 132 µM 0.636145797435517 0.240488730359719 no 856 0.26234069887166 1359 3873677 SGTC_1808 st050063 61.5 µM 0.635517316328895 0.240691251599886 no 857 0.262545538329357 1305 4011993 SGTC_2539 epi(13)torulosol 80 µM 0.635197419651122 0.240794370482524 no 858 0.262649832975923 1265 6708597 SGTC_1954 st077032 68.9 µM 0.63471165977446 0.240951001420335 no 859 0.262808243869252 1210 698907 SGTC_40 0327-0103 19.753 µM 0.63362243593533 0.241302417763251 no 860 0.263163627608871 1255 409036 SGTC_2779 methotrexate 400 µM 0.632069081234007 0.241804058085269 no 861 0.263670868856505 1336 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_319 1348-1596 45.5 µM 0.631580213742248 0.241962049936082 no 862 0.263830609535321 1359 5380505 SGTC_1695 st026914 34.495 µM 0.629143218285337 0.242750471051156 no 863 0.26462764929209 1272 3289191 SGTC_2497 7-hydroxyflavone 100 µM 0.628704481164521 0.242892559629258 no 864 0.264771271928255 1311 5281894 SGTC_1146 3579-1023 7 µM 0.62675545910228 0.243524309868899 no 865 0.265409772092305 1381 X1146 SGTC_2324 6149169 200 µM 0.626665496958731 0.243553491345294 no 866 0.265439262569656 1225 2888231 SGTC_2183 6420625 130.508 µM 0.625007377749196 0.24409168192614 no 867 0.265983107964961 1294 2897619 SGTC_442 cape 100 µM 0.622852666921153 0.244792012889445 no 868 0.266690672484659 1325 5281787 SGTC_2163 5671233 125 µM 0.622129756439452 0.245027217640268 no 869 0.266928275005864 1387 701023 SGTC_2886 9058944 51.95 µM 0.622038753352291 0.245056834841 no 870 0.266958193011289 1203 4949929 SGTC_1162 k048-0130 20.1 µM 0.621061878134692 0.245374882769764 no 871 0.267279455325876 1297 6797406 SGTC_373 0844-0104 25.9 µM 0.620650259408123 0.245508962689255 no 872 0.26741488166006 1313 5375804 SGTC_80 0159-0065 512.242 µM 0.619979089376686 0.245727672758003 no 873 0.267635776955408 1274 1548079 SGTC_2396 5342950 42.78 µM 0.61966557404395 0.2458298719149 no 874 0.26773899254153 1325 1886677 SGTC_1792 st045773 43.6 µM 0.619178634366857 0.245988648850197 no 875 0.267899342687777 1269 2919270 SGTC_2887 9044784 58.44 µM 0.618739990078416 0.246131725151315 no 876 0.268043830470375 1300 6465546 SGTC_529 4076-0302 30.3 µM 0.617400476384231 0.246568921730961 no 877 0.268485303939774 1304 5816522 SGTC_1426 4048-4480 71.7 µM 0.617067979506474 0.246677507987253 no 878 0.268594944007343 1341 14224343 SGTC_233 rapamycin 362 pM 0.61470631812016 0.247449511673255 no 879 0.269374343280324 1331 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1258 0671-0043 57.1 µM 0.614430522403489 0.24753975067653 no 880 0.269465435712383 1295 4298767 SGTC_2769 toremifene 3.73 µM 0.611825822764815 0.248392862019911 no 881 0.270326501455368 1343 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_263 alizarin 107.927 µM 0.611016995137479 0.248658094004826 no 882 0.270594164583595 1328 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_208 k072-0098 12.366 µM 0.607565468726848 0.249791616991749 no 883 0.271737854521701 1323 5948901 SGTC_417 st075190 100 µM 0.607073245395519 0.249953492312868 no 884 0.27190115233328 1381 222757 SGTC_3260 9137109 49.47 µM 0.605464482591655 0.250482947142196 no 885 0.272435208571609 1241 17478346 SGTC_3314 9135860 59.4275 µM 0.604749316480532 0.250718503872544 no 886 0.272672787313259 1323 25252478 SGTC_1106 tegaserod maleate 11.7 µM 0.604491246890469 0.250803533938632 no 887 0.272758543471527 1360 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2920 7982904 15.77 µM 0.60279611549571 0.251362433649845 no 888 0.273322165621211 1319 6456808 SGTC_715 0868-0130 184 µM 0.602682257651883 0.251399997162718 no 889 0.273360043409875 1431 2876258 SGTC_1059 3448-6867 171 µM 0.602617188769648 0.251421465753752 no 890 0.273381691442051 1320 3934407 SGTC_3072 9116419 49.47 µM 0.602414994346194 0.251488183231661 no 891 0.273448965747484 1301 17170162 SGTC_1628 st004252 77.7 µM 0.601097948406952 0.251922993706201 no 892 0.273887374884933 1387 692968 SGTC_2764 methyldopa 94.69 µM 0.600699017640247 0.252054775238644 no 893 0.274020236733251 1392 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2685 mycophenolic acid 18.85 µM 0.597085049648945 0.253250257211846 no 894 0.2752252994577 1328 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_686 1319-0111 510 µM 0.596544845858712 0.253429209623792 no 895 0.27540565206709 1426 4562600 SGTC_548 1436-0017 110 µM 0.595816796898328 0.253670494288479 no 896 0.275648810681811 1416 9677137 SGTC_2622 2-methoxyxanthone 59.94 µM 0.595319127986958 0.253835497475776 no 897 0.275815086153424 1401 71034 A hepatoprotective. SGTC_251 melphalan 456.522 µM 0.594624439828006 0.254065916991496 no 898 0.276047269836243 1430 460612 A DNA alkylator. SGTC_922 1866-0035 480 µM 0.593817900129256 0.254333573871055 no 899 0.276316957683711 1389 3156169 SGTC_1969 st069479 40.1 µM 0.593566556852429 0.254417014417298 no 900 0.276401027355031 1379 3895485 SGTC_3324 9138759 60.749 µM 0.592887480703603 0.254642524771819 no 901 0.276628228465895 1361 45595710 SGTC_901 1112-0062 60.1 µM 0.592799872727438 0.254671625605144 no 902 0.276657546467012 1359 1908457 SGTC_2738 aclarubicin 5.55 µM 0.592088811814662 0.254907883871923 no 903 0.276895559254672 1320 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2241 6772625 37.8075 µM 0.590946972327896 0.255287513184763 no 904 0.277277975838887 1284 2285411 SGTC_2754 granisetron 64.02 µM 0.590142123955907 0.255555279969573 no 905 0.277547684925044 1399 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_161 4065-0411 162.148 µM 0.589587331794516 0.255739940383427 no 906 0.27773367342051 1381 1906281 YLR208W SEC13 SGTC_2689 tacrolimus 100 µM 0.588204076483141 0.256200654733734 no 907 0.278197660757597 1368 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3162 9099653 49.47 µM 0.587233436720027 0.256524199343171 no 908 0.278523469384958 1339 25237511 SGTC_479 n-linoleoylglycine 10 µM 0.586458771647173 0.256782572091267 no 909 0.278783629702595 1351 6433346 An anti-infammatory. SGTC_2445 5742597 35.57 µM 0.586304427205087 0.256834066513617 no 910 0.278835478229204 1321 1774255 SGTC_2060 5238662 140 µM 0.582457228977688 0.258119353836746 no 911 0.280129371528716 1349 790130 SGTC_1024 4507-0395 26 µM 0.58147290223749 0.258448736639767 no 912 0.28046088805661 1396 4201836 SGTC_2938 9059746 27.26 µM 0.581342352962488 0.258492438366398 no 913 0.280504870687054 1374 6471769 SGTC_3217 9129673 49.47 µM 0.580467569203437 0.25878537334255 no 914 0.280799675321862 1349 17248312 SGTC_1310 1188-0297 994 nM 0.580075280684833 0.258916793039923 no 915 0.280931926315647 1325 1588352 SGTC_2819 7996655 46.38 µM 0.576493710849124 0.260118241300488 no 916 0.282140759807056 1332 6456960 SGTC_3018 9082602 49.47 µM 0.576313281410032 0.2601788428418 no 917 0.282201723637995 1362 17332089 SGTC_2037 5169046 200 µM 0.575249374653883 0.260536329268182 no 918 0.28256132726806 1390 5718022 SGTC_2196 6573537 42.6665 µM 0.573693879221805 0.261059450649649 no 919 0.28308748548169 1445 2903087 SGTC_3050 9093513 49.47 µM 0.573384323640195 0.261163620221249 no 920 0.283192251092285 1362 25236664 SGTC_1176 0848-0131 83.3 µM 0.573121361345284 0.26125212730992 no 921 0.28328126233734 1432 6769040 SGTC_945 3381-0768 11.3 µM 0.572419815133983 0.261488327082184 no 922 0.283518797377949 1371 1126236 YIL048W NEO1 SGTC_1656 st012921 11 µM 0.57065219812178 0.2620839422032 no 923 0.284117713928242 1391 6732821 SGTC_2114 5491910 81.25 µM 0.570526796267168 0.262126223933176 no 924 0.284160226451476 1450 2849228 SGTC_2045 5106652 78.05 µM 0.570389871647861 0.262172394784389 no 925 0.284206648784622 1389 673349 SGTC_3298 9116858 71.43 µM 0.570201136386101 0.262236042964709 no 926 0.284270642717913 1453 2506942 SGTC_1719 st032227 49.2 µM 0.569911874550474 0.262333607608873 no 927 0.284368735279441 1367 3125804 SGTC_1448 4255-0083 152 µM 0.569521085642688 0.262465445667288 no 928 0.284501282712281 1509 5399660 SGTC_2513 baicalein 25.65 µM 0.569347201568617 0.26252411877388 no 929 0.284560270042583 1320 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_492 tmb-8 126 µM 0.56849554344736 0.262811587787826 no 930 0.284849265469011 1306 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1707 st032323 6.317 µM 0.565727765362584 0.263746935138754 no 931 0.285789428763593 1356 3132057 YMR211W DML1 SGTC_2866 9034245 58.44 µM 0.565559028689728 0.263804013137128 no 932 0.285846793203106 1391 6462273 SGTC_345 1362-0200 395 µM 0.565074278927345 0.263968022873772 no 933 0.28601162125232 1368 1419823 SGTC_321 4534-3890 65.3 µM 0.564409923411828 0.264192884624088 no 934 0.286237593468618 1420 699746 SGTC_1346 1488-2224 62.4 µM 0.561774511716926 0.265085841945884 no 935 0.287134830015455 1409 3722427 SGTC_2136 5328288 199.296 µM 0.561454261555087 0.265194456778387 no 936 0.287243951145537 1366 262395 SGTC_359 0081-0058 15.9 µM 0.561242918883005 0.265266147334504 no 937 0.287315974195064 1540 3494159 SGTC_3183 9108214 49.47 µM 0.560987792761159 0.265352702989245 no 938 0.287402929501021 1338 4974831 SGTC_431 k089-0097 107 µM 0.558675645388969 0.266137789387227 no 939 0.288191551807385 1341 5499420 SGTC_565 1418-0001 44.5 µM 0.558397084621639 0.266232453629056 no 940 0.288286631580829 1439 2862145 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.558260570440464 0.266278851924672 no 941 0.288333232693927 1365 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1322 1348-1070 12 µM 0.556666001782794 0.266821115158423 no 942 0.28887782490644 1385 6758089 SGTC_2842 9000675 19.48 µM 0.556291189833988 0.266948657999178 no 943 0.289005904472328 1348 2989072 SGTC_2401 5128683 200 µM 0.556109603040166 0.267010460312101 no 944 0.289067965347914 1322 708373 SGTC_1509 1326-1131 80 µM 0.556093655000303 0.267015888506545 no 945 0.289073416205137 1369 768313 SGTC_2409 alverine citrate 63.97 µM 0.555427239470173 0.267242764501347 no 946 0.289301232598383 1527 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_32 0928-0142 34.1 µM 0.555011792481303 0.267384249414749 no 947 0.289443297233166 1375 2244242 SGTC_813 k007-0158 173 µM 0.554849451423504 0.267439546663065 no 948 0.289498819652198 1462 6523916 SGTC_99 0109-0120 622.8 µM 0.552076915751189 0.268384828164681 no 949 0.290447828462598 1471 759414 SGTC_2646 retinol 96.75 µM 0.551442218154618 0.26860146109767 no 950 0.290665283217369 1406 445354 A vitamin A analog and teratogen. SGTC_2551 apiole 73.87 µM 0.550033178585939 0.269082703822917 no 951 0.2911483085 1356 10659 A possible DNA adduct former. SGTC_786 4544-0069 423 µM 0.547808297533624 0.269843468646987 no 952 0.291911770282613 1477 748821 YLR208W SEC13 SGTC_334 1502-1024 68.5 µM 0.547770381336815 0.269856442849941 no 953 0.291924789197142 1413 3296216 SGTC_1942 st076330 65.2 µM 0.546630729826464 0.270246555671578 no 954 0.292316226363075 1436 24208414 SGTC_2658 polymyxin b sulfate 77.05 µM 0.546594939086896 0.270258811724841 no 955 0.292328523394184 1394 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1521 st012942 49.4 µM 0.546050942266904 0.270445130264647 no 956 0.292515460173586 1553 24207259 SGTC_1026 k007-1105 30.6 µM 0.544766959006721 0.270885148050743 no 957 0.292956902951698 1410 7066794 SGTC_1080 nisoldipine 24.4 µM 0.542870030404017 0.271535873782656 no 958 0.29360964590746 1401 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2567 aureobasidin a 60 nM 0.538700985777618 0.272968760446094 no 959 0.295046596716326 1507 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_167 3672-0051 66.205 µM 0.537258762452614 0.273465319100874 no 960 0.295544443024017 1381 3237971 SGTC_3289 9119912 71.43 µM 0.536763504748234 0.273635939813454 no 961 0.295715491879919 1443 17014829 SGTC_124 0136-0217 7.121 µM 0.536762281954642 0.273636361141966 no 962 0.295715914256638 1537 3976905 SGTC_2390 9097792 176.6 µM 0.535865002670011 0.273945616218181 no 963 0.296025926703901 1381 4497149 SGTC_1713 st033146 12.748 µM 0.535807338410548 0.273965496611117 no 964 0.296045854963952 1512 674619 SGTC_2703 st077852 53.4 µM 0.533906845719946 0.274621111296667 no 965 0.296702992770214 1448 6281836 SGTC_806 3966-4455 5.86 µM 0.532746576075947 0.275021750652463 no 966 0.297104509999672 1370 714982 SGTC_1246 0422-0085 105 µM 0.532261703396511 0.275189261718157 no 967 0.297272376239405 1458 264295 SGTC_62 0180-0423 3.232 µM 0.531370091424485 0.275497421827125 no 968 0.297581171477596 1391 30102 YGL099W LSG1 SGTC_1118 chelidonine 707.474 nM 0.53005211551002 0.275953253073921 no 969 0.298037898879291 1524 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1411 3909-8223 150 µM 0.52960013246509 0.27610965984862 no 970 0.298194601248361 1496 X1411 SGTC_738 1315-0003 72.4 µM 0.52926445696342 0.276225847057171 no 971 0.298311004108954 1500 6251474 SGTC_2407 paclitaxel 400 µM 0.529013472854401 0.276312735746059 no 972 0.298398051880768 1573 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3287 9117173 37.0625 µM 0.528018062506842 0.276657470825626 no 973 0.298743399686045 1419 2789709 SGTC_3020 9089140 49.47 µM 0.527271211090467 0.276916262159227 no 974 0.299002631650589 1445 17217859 SGTC_1851 st056236 18.9 µM 0.526677614068665 0.277122033853376 no 975 0.299208741879008 1482 5393171 SGTC_1916 st067606 49.2 µM 0.52648218322545 0.277189796746854 no 976 0.299276613964943 1533 19590279 SGTC_1670 st016595 4.04 µM 0.525053491584017 0.27768542155544 no 977 0.299773002950389 1433 597879 SGTC_819 1013-0258 27.7 µM 0.524190369190802 0.277985055367085 no 978 0.300073069374354 1437 5753198 SGTC_2533 agelasine 13.65 µM 0.518203622975028 0.280067691783984 no 979 0.302158103633903 1597 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1930 st074634 34.3 µM 0.516553357072464 0.280643104026226 no 980 0.302733991427943 1406 684253 YOR116C RPO31 SGTC_1382 3002-2117 298 µM 0.516476440063889 0.280669937277279 no 981 0.302760844887931 1554 1497314 SGTC_276 colchicine 750 µM 0.516068177276646 0.280812384518229 no 982 0.302903396477578 1484 2833 A microtubule depolymerizer. SGTC_2418 pentamidine 31.67 µM 0.515872648497237 0.280880618972425 no 983 0.302971679168687 1401 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_18 0111-0177 500 nM 0.515868299747602 0.280882136663954 no 984 0.30297319792025 1499 721752 SGTC_1096 rimcazole 32.2 µM 0.515027882530802 0.281175512388203 no 985 0.303266768043951 1415 18528119 A dopamine reuptake inhibitor. SGTC_658 3253-0951 102 µM 0.5145861798868 0.281329762767244 no 986 0.303421112252035 1481 1184878 SGTC_121 0557-0495 61.343 µM 0.514181715344131 0.281471044758728 no 987 0.303562475119758 1515 3104427 SGTC_612 0302-0167 22.4 µM 0.514139869503424 0.281485663726106 no 988 0.30357710217939 1550 235821 SGTC_1915 st067105 30.6 µM 0.51413320038825 0.281487993634925 no 989 0.303579433373133 1410 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2809 7964133 12.99 µM 0.513996295334068 0.28153582456828 no 990 0.303627290394019 1494 1253665 SGTC_2522 biochanin a 4.94 µM 0.510199973614852 0.282863716220617 no 991 0.304955685336684 1511 5280373 A possible chelator. SGTC_3095 9117207 49.47 µM 0.510105480753112 0.282896806618407 no 992 0.304988782840248 1473 17015229 SGTC_1037 k284-1091 78.7 µM 0.509095878442038 0.283250474622967 no 993 0.305342510321578 1438 3334711 SGTC_162 k030-0015 37.8 µM 0.508954408133054 0.283300049212244 no 994 0.305392090842462 1587 1809920 YMR134W ERG29 SGTC_2898 9056270 58.44 µM 0.507901790867328 0.283669042149228 no 995 0.305761109366011 1460 19154699 SGTC_1276 0871-0068 94.2 µM 0.507019094717176 0.28397864692191 no 996 0.306070710381825 1534 3414906 SGTC_2808 7946468 45.46 µM 0.504631343992546 0.28481695734375 no 997 0.3069088953452 1516 2970879 SGTC_1828 st055811 49 µM 0.503278918605282 0.285292300784963 no 998 0.307384093015479 1493 5877589 SGTC_717 1532-0246 73.2 µM 0.50286992763954 0.285436125194183 no 999 0.307527862697849 1443 9561992 SGTC_1591 genipin 88.4 µM 0.502794807574715 0.285462545420027 no 1000 0.307554272334534 1518 442424 A DNA cross-linking agent. SGTC_3325 9138760 55.175 µM 0.498773245754521 0.286878652248659 no 1001 0.308969568737053 1444 43844959 SGTC_3152 9099253 49.47 µM 0.498363292557165 0.287023195241861 no 1002 0.309114002252711 1523 25236131 SGTC_691 1548-0686 185 µM 0.496969354236676 0.287514933640455 no 1003 0.309605331203863 1444 46495133 SGTC_1798 st045719 60.953 µM 0.496514333267336 0.287675537183287 no 1004 0.309765788643689 1431 3980186 SGTC_1262 0737-0114 49.6 µM 0.495960227407438 0.287871170815119 no 1005 0.309961236082736 1511 765919 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.494969050370195 0.288221274228055 no 1006 0.310310983767955 1450 6312947 SGTC_814 3342-0569 96 µM 0.494263670911505 0.288470550522172 no 1007 0.310559989191198 1515 4346283 SGTC_2335 9018011 154.17 µM 0.492930881851786 0.288941826260032 no 1008 0.311030712910211 1596 6458208 SGTC_2213 7173844 200 µM 0.492874758262392 0.28896167957192 no 1009 0.311050541822399 1464 892728 SGTC_10 0279-0212 42.575 µM 0.491363356937999 0.289496568022288 no 1010 0.31158473810407 1482 39851 YBR002C RER2 SGTC_201 4262-0159 12.803 µM 0.489404079685846 0.290190652101014 no 1011 0.312277824170205 1564 1341029 SGTC_1267 0828-0272 9.49 µM 0.488435695255148 0.290533994949765 no 1012 0.312620631735797 1606 745334 SGTC_3226 9131256 49.47 µM 0.488353369192296 0.290563192603473 no 1013 0.312649782601065 1417 17178073 SGTC_1813 st051246 8.6015 µM 0.487410388361691 0.29089772683967 no 1014 0.312983766581506 1552 5291959 SGTC_1854 st056233 32.9 µM 0.485786166331044 0.29147436158406 no 1015 0.313559391733407 1571 5393174 SGTC_2759 disulfiram 3.38 µM 0.485238157716087 0.291669036982715 no 1016 0.313753708847844 1445 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1054 3429-0080 167 µM 0.484059261050315 0.292088035294043 no 1017 0.31417190621352 1565 1162877 SGTC_649 1123-0311 367 µM 0.479952381101971 0.293549868111047 no 1018 0.315630626776924 1494 693629 YIL048W NEO1 SGTC_1475 4092-1048 11.7 µM 0.479329341318789 0.293771933070532 no 1019 0.315852175858161 1493 2881759 SGTC_2087 5276107 200 µM 0.477524567919355 0.294415631928305 no 1020 0.316494315319177 1481 144405 SGTC_1487 3970-0795 2.82 µM 0.477101896134117 0.294566478060466 no 1021 0.316644782268877 1553 3765103 SGTC_269 exalamide 29 µM 0.476808616681866 0.294671166682645 no 1022 0.316749204669955 1555 3316 A derivative of salicylamide. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.47645594617423 0.29479707817322 no 1023 0.316874792645312 1537 2724278 An inhibitor of dopamine biosynthesis. SGTC_357 1325-0123 420 µM 0.474850714223633 0.29537049607373 no 1024 0.317446691347194 1560 1098503 SGTC_204 PMA1.184 62.41 µM 0.474349286293547 0.295549720333308 no 1025 0.317625425365041 1506 2252213 YGL008C PMA1 SGTC_409 arachidonic acid 100 µM 0.473061334499619 0.296010299059816 no 1026 0.318084710640209 1529 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3069 9117009 49.47 µM 0.471344370146138 0.296624806915263 no 1027 0.318697417554261 1473 41904981 SGTC_3232 9132874 49.47 µM 0.470571681128321 0.296901545675091 no 1028 0.318973317250042 1486 3784940 SGTC_1529 apigenin 74 µM 0.469160954759185 0.29740710217034 no 1029 0.319477296063275 1611 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3125 9127534 49.47 µM 0.467847106351691 0.29787829419498 no 1030 0.319946965547616 1485 1639235 SGTC_1785 bathophenanthroline 24 µM 0.467284305690005 0.298080238293582 no 1031 0.320148241751348 1477 72812 An iron chelator. SGTC_2711 st079103 59.1 µM 0.466232856453942 0.298457686277775 no 1032 0.320524416713715 1634 54693780 SGTC_47 0149-0135 24.25 µM 0.461732818969392 0.300075555778726 no 1033 0.322136466445309 1424 5239155 SGTC_182 3448-4371 550.524 µM 0.460935870556506 0.30036249051054 no 1034 0.322422307729733 1661 3491403 SGTC_2848 9016370 25.97 µM 0.460717857619428 0.30044100586975 no 1035 0.322500520674764 1626 7894410 SGTC_1356 1502-0781 85.8 µM 0.459615702506573 0.300838078756772 no 1036 0.322896043077518 1539 567702 SGTC_1430 4049-0248 69.1 µM 0.4595113245621 0.300875695215748 no 1037 0.322933510826967 1639 22774488 SGTC_1101 ebselen 5.29 µM 0.459431813513167 0.300904351391123 no 1038 0.322962053503729 1673 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3202 9113761 49.47 µM 0.458972260009909 0.301070000856516 no 1039 0.323127043291152 1696 4798415 SGTC_2282 7944268 200 µM 0.458097435958862 0.301385451198604 no 1040 0.323441220479176 1612 2970414 SGTC_601 0986-0029 62.9 µM 0.456935578559074 0.301804631949493 no 1041 0.323858675145761 1544 24747981 SGTC_3338 9144300 39.5675 µM 0.45625847391945 0.30204904195849 no 1042 0.324102060706144 1584 4901274 SGTC_2804 7954240 19.48 µM 0.454244618138034 0.302776494973151 no 1043 0.324826386157936 1649 828705 SGTC_169 k015-0017 16.025 µM 0.45414490180076 0.302812535285768 no 1044 0.324862268472886 1638 1840002 SGTC_1866 st057638 64 µM 0.452735248295482 0.303322229432544 no 1045 0.325369697403255 1553 688802 SGTC_465 cgp-37157 41 µM 0.449180334616978 0.304609293403869 no 1046 0.326650786231916 1608 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1946 st076057 65.1 µM 0.446323939640115 0.305645213763861 no 1047 0.327681632968603 1503 953009 SGTC_1111 tnp00062 510.699 nM 0.446134670455702 0.305713910571327 no 1048 0.327749985009839 1671 676306 SGTC_2865 9030313 51.95 µM 0.445637188848077 0.305894508216872 no 1049 0.327929671374708 1504 42562754 SGTC_1298 1079-1278 263 µM 0.444623390636872 0.306262687146708 no 1050 0.328295970435823 1564 2840950 SGTC_2661 dactinomycin 12.96 µM 0.444315038099635 0.306374709715723 no 1051 0.328407415163511 1560 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2057 5236571 38.335 µM 0.44133868276199 0.307456930485903 no 1052 0.32948391282645 1661 54684039 YBR257W POP4 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.440714226400476 0.307684199896964 no 1053 0.329709948025811 1544 279621 SGTC_3199 9111318 49.47 µM 0.440582451016397 0.307732168670803 no 1054 0.329757654867746 1628 8548020 SGTC_1494 4358-1428 177 µM 0.439978404551665 0.307952095254449 no 1055 0.329976374162892 1689 1564571 SGTC_962 1254-0300 21.5 µM 0.43538975567923 0.30962501946299 no 1056 0.331639772495384 1596 7340576 SGTC_1650 st011916 45.8 µM 0.434719679078278 0.309869646685911 no 1057 0.331882956209703 1660 242528 SGTC_1152 3909-8331 15.9 µM 0.434519985198944 0.309942565925803 no 1058 0.331955442674853 1569 16001939 SGTC_1820 st053765 18.6 µM 0.433158044221348 0.310440084902904 no 1059 0.332449978407885 1547 3690829 SGTC_2 0422-0095 29 µM 0.432964041386328 0.310510982670751 no 1060 0.332520446731934 1534 6790840 SGTC_2151 5563267 85.4165 µM 0.432283628458086 0.310759693210071 no 1061 0.332767642256553 1572 5310824 SGTC_833 3852-0053 558 µM 0.4310983878651 0.311193139334385 no 1062 0.333198416398836 1640 3123681 SGTC_424 splitomicin 100 mM 0.429038128418121 0.311947205738868 no 1063 0.333947738676556 1542 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1501 4491-0275 38.4 µM 0.428863520206287 0.312011149618048 no 1064 0.334011274680437 1654 5104718 SGTC_1133 3473-0247 50 µM 0.428044895084463 0.31231101668439 no 1065 0.334309217382282 1514 711311 SGTC_872 0588-0139 234 µM 0.426825480941219 0.312757925616551 no 1066 0.334753222819399 1582 2047100 SGTC_603 3794-0023 45.9 µM 0.426630041586856 0.312829578743865 no 1067 0.334824406479407 1679 3802260 SGTC_767 0929-0023 86 µM 0.426472465502663 0.312887355366001 no 1068 0.334881803758283 1582 1204563 SGTC_1877 wortmannin 25 µM 0.425769597700369 0.313145123830113 no 1069 0.335137871162961 1664 312145 A covalent inhibitor of PI 3-kinase. SGTC_248 streptozotocin 5.23457 mM 0.424900015770735 0.313464159133216 no 1070 0.335454781583083 1672 5300 DNA alkylating agent. SGTC_202 3594-0513 34.79 µM 0.424855183949226 0.313480610977235 no 1071 0.335471123267476 1603 708429 SGTC_1257 0669-0121 16 µM 0.424307729445741 0.313681539187407 no 1072 0.335670701461484 1703 4307855 SGTC_622 1348-1566 26.3 µM 0.42426550624327 0.31369703835664 no 1073 0.335686096138344 1671 7340407 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.422417979457632 0.31437554473779 no 1074 0.336359978383687 1674 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2285 7945142 200 µM 0.420592532978907 0.315046558586711 no 1075 0.337026323610009 1599 2970608 SGTC_1234 0326-0494 15.5 µM 0.420341860770398 0.315138750654819 no 1076 0.337117866836031 1685 1547813 SGTC_445 e6 berbamine 66 µM 0.419998952428232 0.315264883920663 no 1077 0.337243109487197 1586 6610268 A calcium/calmodulin antagonist. SGTC_2460 5552655 174.22 µM 0.419823138186237 0.315329562687639 no 1078 0.337307330266097 1538 5401989 SGTC_2307 7538926 6.34 µM 0.419063825628588 0.315608964544077 no 1079 0.337584743586166 1591 96582 SGTC_2021 4019055 173 µM 0.418101846677927 0.315963092307201 no 1080 0.33793632742821 1601 44827708 YER133W GLC7 SGTC_713 1488-1073 324 µM 0.415819734245318 0.316803868570343 no 1081 0.338770958615716 1637 3312542 SGTC_1441 4106-0040 13 µM 0.415047188515398 0.317088704801529 no 1082 0.339053679509553 1595 2904180 SGTC_3203 9113543 49.47 µM 0.41453639767383 0.317277092019804 no 1083 0.339240658364703 1663 17018012 SGTC_1824 st053723 68.6 µM 0.413665195106503 0.31759851365259 no 1084 0.339559659998473 1547 675225 SGTC_2400 5203494 178.7 µM 0.413554825349491 0.31763924331178 no 1085 0.339600081465355 1561 6777674 SGTC_1479 0549-0158 134 µM 0.412822641556726 0.317909496355674 no 1086 0.339868280815817 1613 5440202 SGTC_1572 epiandrosterone 68.9 µM 0.412813252409861 0.317912962571439 no 1087 0.339871720592568 1660 441302 A steroid. SGTC_2191 5911152 200 µM 0.411270864255292 0.318482586399072 no 1088 0.340436965611824 1615 2875902 SGTC_2694 st077685 81.9 µM 0.409579789410033 0.319107615571735 no 1089 0.341057112584173 1559 2838096 SGTC_1406 3909-7906 11.9 µM 0.409221297527292 0.319240182016861 no 1090 0.341188633129461 1642 X1406 SGTC_2332 7982454 138.89 µM 0.408558236934667 0.319485435601967 no 1091 0.341431942170286 1590 2981748 SGTC_2071 5230951 39.92 µM 0.4068431156658 0.320120192733077 no 1092 0.34206160879467 1633 1799272 SGTC_2616 abietic acid 100 µM 0.406012862809676 0.320427654208745 no 1093 0.342366574670532 1731 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_884 0851-0618 334 µM 0.404170334014153 0.321110424617864 no 1094 0.343043733599049 1721 9642473 SGTC_2874 9043904 71.43 µM 0.403874187118424 0.321220221797778 no 1095 0.343152619447418 1614 4463428 SGTC_2973 9094665 17.96 µM 0.403329108594433 0.321422351833057 no 1096 0.343353065305617 1735 25237061 YIL048W NEO1 SGTC_2073 5212005 126 µM 0.402800223980441 0.321618527285694 no 1097 0.343547598182481 1648 691789 SGTC_2220 6782180 200 µM 0.402517880963205 0.32172327516955 no 1098 0.343651465782638 1662 833803 SGTC_1884 5633444 25 µM 0.401753376022088 0.322006973898886 no 1099 0.343932769070374 1651 5724239 SGTC_3230 9131665 49.47 µM 0.401052998541942 0.322266966766765 no 1100 0.344190552197095 1634 15943720 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.400346353144866 0.322529374552151 no 1101 0.344450715706138 1576 2333 A French combination drug. SGTC_1805 st050013 60.3 µM 0.399486622372593 0.322848748749134 no 1102 0.344767339445577 1668 4037144 SGTC_2328 6201408 200 µM 0.398930688553689 0.323055337552853 no 1103 0.344972138020977 1608 2890418 SGTC_2570 licareol 100 µM 0.397556597510774 0.323566193304349 no 1104 0.345478529544909 1593 443158 SGTC_755 1995-0008 37.3 µM 0.397449596156984 0.323605987944943 no 1105 0.345517974201758 1616 689533 SGTC_2730 imipramine 71.33 µM 0.395175730880164 0.324452132542508 no 1106 0.346356601049431 1684 3696 A tricyclic antidepressant. SGTC_1712 st032288 53.4 µM 0.395004817100744 0.324515769222562 no 1107 0.346419666464296 1605 2883011 SGTC_575 k072-0246 11.9 µM 0.394599059808484 0.324666866192298 no 1108 0.346569403753642 1648 6796779 SGTC_2029 5175081 200 µM 0.394349232384579 0.324759911942909 no 1109 0.346661609911257 1617 1380876 SGTC_1285 0929-0069 65.5 µM 0.392927759486532 0.32528953342906 no 1110 0.347186419037842 1639 1206237 SGTC_383 2324-0395 7.37 µM 0.39224089837747 0.325545575139484 no 1111 0.347440113927733 1705 3146421 SGTC_118 0083-0097 135.343 µM 0.391017455584182 0.326001842690245 no 1112 0.347892166658059 1653 5207356 SGTC_302 1094-0063 18.9 µM 0.389514305849874 0.326562780235661 no 1113 0.348447865038915 1626 5440289 SGTC_2212 7123476 200 µM 0.387267414368465 0.327401994780239 no 1114 0.349279123303439 1707 1085715 SGTC_1565 sinapyl alcohol 95.1 µM 0.386770690112556 0.327587639398105 no 1115 0.349462988826909 1579 5280507 A phenol propionate derived from cinnamic acid. SGTC_3149 9097855 49.47 µM 0.386594502009843 0.327653497792799 no 1116 0.349528214421069 1785 25236625 YMR079W SEC14 SGTC_2682 pyrogallin 40.03 µM 0.386444273005598 0.327709657017704 no 1117 0.349583833354487 1686 822798 An ATP competetive kinase inhibitor. SGTC_1190 1486-1332 13 µM 0.384789189061897 0.328328625067856 no 1118 0.3501968047341 1596 4150046 SGTC_1797 st048695 56.8 µM 0.383109051893178 0.328957444871594 no 1119 0.35081945414688 1748 592262 YIL048W NEO1 SGTC_327 1273-0057 3.96 µM 0.382851046385277 0.329054050751877 no 1120 0.350915105088336 1665 3108138 SGTC_1676 st018489 23.4 µM 0.38117426765057 0.329682170719738 no 1121 0.351536970906883 1663 3696235 SGTC_2146 5545642 200 µM 0.381020519785376 0.329739788631894 no 1122 0.351594011197775 1654 825326 SGTC_156 3474-0145 5.642 µM 0.379501949288513 0.330309098683493 no 1123 0.352157578515598 1801 2265471 SGTC_2369 9071472 200 µM 0.378017308830805 0.330866068412547 no 1124 0.352708867897736 1711 17296037 SGTC_790 1575-0012 79.1 µM 0.376342953270118 0.331494660093394 no 1125 0.353330975188661 1760 378741 YLR208W SEC13 SGTC_1882 5615643 20 µM 0.375995329207984 0.331625225774949 no 1126 0.353460184216741 1628 2253075 SGTC_3068 9116768 49.47 µM 0.375669943377699 0.331747457438012 no 1127 0.353581142778975 1652 41904888 SGTC_1552 6-methylflavone 10.6 µM 0.374923804943988 0.332027813053798 no 1128 0.353858567251747 1769 689013 SGTC_3088 9117578 49.47 µM 0.374814495106024 0.332068893263895 no 1129 0.353899216666006 1686 678341 SGTC_3084 9116877 49.47 µM 0.372872124263545 0.33279920037423 no 1130 0.354621809940385 1761 27241325 SGTC_797 k781-0471 270 µM 0.371717734093965 0.333233537581233 no 1131 0.355051509881452 1732 23738129 SGTC_3127 9126946 49.47 µM 0.371412440573814 0.333348441148311 no 1132 0.355165180485913 1602 27243249 SGTC_1806 st050005 60.3 µM 0.371169396738506 0.333439926934102 no 1133 0.355255682744832 1642 5194765 SGTC_2908 7930301 100 µM 0.370325781022534 0.333757554924184 no 1134 0.355569883343744 1588 2223178 SGTC_395 anisomycin 6.25 µM 0.367613963409808 0.334779381984296 no 1135 0.356580550774024 1666 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2856 9022925 19.48 µM 0.367598501343065 0.334785211690023 no 1136 0.356586316228666 1691 4944862 SGTC_2583 asiatic acid 100 µM 0.366690912357272 0.335127472196242 no 1137 0.356924792989464 1698 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2033 5192550 145 µM 0.366420904070071 0.335229321351843 no 1138 0.357025511791847 1639 182073 SGTC_109 0132-0036 33.701 µM 0.366414240746757 0.335231834960679 no 1139 0.35702799747841 1698 67274 A color developer. SGTC_1170 0310-0127 64.8 µM 0.366037004245999 0.335374152106303 no 1140 0.357168731701935 1730 774975 SGTC_1602 st001878 87.6 µM 0.365048585811669 0.335747157228166 no 1141 0.357537569430985 1743 595405 YLR310C CDC25 SGTC_2176 5809774 33.9695 µM 0.36502080297628 0.335757644136514 no 1142 0.357547938784731 1810 2870539 SGTC_2922 7999257 32.47 µM 0.364445555263064 0.33597480585352 no 1143 0.3577626614062 1647 2988377 SGTC_1795 st049545 62.3 µM 0.36408088991808 0.336112499006525 no 1144 0.357898803300771 1806 5291882 SGTC_147 4466-0538 29.23 µM 0.363172205682313 0.336455702655925 no 1145 0.35823812443658 1713 6742687 YHR072W ERG7 SGTC_3013 9080133 71.4286 µM 0.363119911430894 0.336475457977637 no 1146 0.35825765558188 1736 17050193 SGTC_1214 0358-0031 63.7 µM 0.362749561294621 0.336615378931223 no 1147 0.358395986603857 1852 4301366 SGTC_2348 9022543 33.42 µM 0.362345075021766 0.336768222610827 no 1148 0.358547089189576 1715 3162678 YDL140C RPO21 SGTC_727 3032-0951 202 µM 0.361272282652884 0.337173730399964 no 1149 0.358947955861779 1717 3652836 SGTC_3049 9092223 49.47 µM 0.360199130155751 0.337579563677233 no 1150 0.359349112574142 1702 8623917 SGTC_145 3737-0113 38.366 µM 0.357836856759901 0.338473568108442 no 1151 0.360232703358736 1823 6849351 SGTC_2784 7567673 72.73 µM 0.357492186517563 0.338604085149852 no 1152 0.360361687266181 1655 3471247 SGTC_2252 omeprazole 400 µM 0.357010647394967 0.33878646309175 no 1153 0.360541917417094 1763 4594 A proton pump inhibitor. SGTC_2968 9090663 33.37 µM 0.356900141242493 0.338828321483757 no 1154 0.360583281961042 1695 25236811 SGTC_2742 clothiapine 36.27 µM 0.35377646176645 0.340012355036687 no 1155 0.361753207475035 1794 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1534 6-azauridine 81.6 µM 0.353714903090782 0.340035704818961 no 1156 0.361776276348933 1703 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3308 9128332 17.569 µM 0.351590495831098 0.34084188781659 no 1157 0.362572696954103 1825 17332805 YDL196W YDL196W SGTC_586 0957-0265 8.15 µM 0.351325713565035 0.340942420057806 no 1158 0.362672003145082 1779 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_844 0330-0132 15.3 µM 0.348753554483997 0.34191960147226 no 1159 0.363637167387988 1783 2828079 SGTC_796 1234-0020 70.7 µM 0.348052720605373 0.342186037238494 no 1160 0.363900295217252 1656 46495034 SGTC_271 rotenone 740 µM 0.347798528512762 0.342282692782869 no 1161 0.363995747416967 1772 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1818 st052136 56.3 µM 0.347751666883804 0.342300512861327 no 1162 0.364013345445879 1640 674169 SGTC_1495 4469-0029 237 µM 0.345652979579273 0.343098940460422 no 1163 0.364801762644829 1674 793680 SGTC_2861 9024595 19.48 µM 0.344152235051302 0.343670315976714 no 1164 0.36536590075391 1736 16482810 SGTC_2483 5729050 27.16 µM 0.344029847947767 0.34371692795377 no 1165 0.365411919606207 1839 2865180 SGTC_591 4299-0174 154 µM 0.341899783784829 0.344528557649488 no 1166 0.366213156178157 1754 5509088 SGTC_1970 st070122 35.8 µM 0.340527759824447 0.345051726803285 no 1167 0.366729560614802 1778 102928 SGTC_1775 st081588 35.1725 µM 0.339702344968788 0.345366610192104 no 1168 0.367040347814474 1703 1426443 YGL099W LSG1 SGTC_2732 terfenadine 20 µM 0.33880551363977 0.345708859247136 no 1169 0.367378123704478 1746 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_550 4123-0385 25.7 µM 0.33612393839024 0.346732954329862 no 1170 0.368388703662754 1688 5731123 SGTC_2102 5377816 72.7585 µM 0.335328500558422 0.347036948383853 no 1171 0.368688648352782 1845 1379702 SGTC_1799 st045822 46.1415 µM 0.335321433251409 0.347039649752192 no 1172 0.368691313660598 1842 3674992 SGTC_2773 thioridazine 9.09 µM 0.335075556499666 0.347133637160423 no 1173 0.36878404558991 1751 5452 An antipsychotic. SGTC_2299 7976368 114.88 µM 0.333631636029393 0.347685771341456 no 1174 0.369328771345855 1833 2979718 SGTC_2736 butenafine 14.65 µM 0.331354080539602 0.348557332088496 no 1175 0.370188522951884 1803 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_218 alverine citrate 93.75 µM 0.330707218189806 0.348805015422353 no 1176 0.370432824747004 1803 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_462 ag-879 158 µM 0.329805472402808 0.349150401047821 no 1177 0.370773476075654 1827 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_614 0462-0418 107 µM 0.32950232279574 0.349266541144507 no 1178 0.37088801927671 1716 5188303 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.329487093447668 0.349272376055171 no 1179 0.370893773893462 1700 688803 SGTC_11 0438-0307 1.3 µM 0.328349808885263 0.349708211231618 no 1180 0.371323593878752 1845 4011476 SGTC_2651 TUB2.036 5 µM 0.327587548962387 0.350000438769929 no 1181 0.371611768702154 1819 15992207 YFL037W TUB2 SGTC_1898 st060199 18.6 µM 0.327264807774424 0.350124194825388 no 1182 0.371733803744783 1704 688866 SGTC_1657 st012939 43.4 µM 0.326981401102145 0.350232881072529 no 1183 0.37184097623255 1832 24207257 SGTC_2984 9022109 38.96 µM 0.326751714510206 0.350320974708847 no 1184 0.371927841331413 1767 6459207 SGTC_1556 plumbagin 1.48 µM 0.326659567879892 0.350356318747022 no 1185 0.371962692068754 1764 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1272 0839-0021 27 µM 0.325005021702974 0.35099116170885 no 1186 0.372588635536271 1762 5027250 SGTC_1119 parthenolide 318.541 nM 0.323443589460867 0.351590658963707 no 1187 0.373179661210623 1814 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_92 0063-0024 660.874 µM 0.323032051943863 0.351748726485036 no 1188 0.373335484141391 1844 3594437 SGTC_49 0717-0965 32.132 µM 0.322914954187259 0.351793707269327 no 1189 0.373379825357775 1820 5889349 YGL099W LSG1 SGTC_1893 st059353 36.1 µM 0.320148259596457 0.352857080541933 no 1190 0.374427971697042 1710 3112488 SGTC_2359 9039622 200 µM 0.319842437252248 0.352974693480938 no 1191 0.374543887873212 1817 6463596 SGTC_1147 3809-1045 12.3 µM 0.319541934220026 0.353090274407618 no 1192 0.374657798909593 1738 325925 SGTC_1365 1672-3266 55.4 µM 0.319422643419697 0.353136160370103 no 1193 0.374703021249579 1856 6415873 SGTC_3077 9117319 49.47 µM 0.318347669988699 0.353549751970066 no 1194 0.375110614106662 1779 17154678 SGTC_2065 5221596 34.26 µM 0.317860184133328 0.353737367177876 no 1195 0.375295497936143 1776 788581 SGTC_1863 st057641 20.1 µM 0.316173493500564 0.354386785670105 no 1196 0.375935412839996 1882 3921635 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.313470980558219 0.355428203901618 no 1197 0.376961432318766 1704 6708514 SGTC_2997 9067075 71.4286 µM 0.312147084251162 0.355938764503049 no 1198 0.377464372415502 1809 27209819 SGTC_2350 9023895 38.85 µM 0.311037674835566 0.356366807336768 no 1199 0.377885990381298 1820 2997209 SGTC_1878 temozolomide 1 mM 0.310185561642666 0.356695700656209 no 1200 0.378209924780693 1924 5394 DNA alkylating agent. SGTC_2896 9052656 71.43 µM 0.310048624347535 0.356748564802333 no 1201 0.378261990058914 1781 6469436 SGTC_1498 4478-3555 97.6 µM 0.310032913514139 0.356754630088549 no 1202 0.378267963656324 1891 3437919 SGTC_2386 9075165 157.42 µM 0.309870455837708 0.356817350228113 no 1203 0.378329735271494 1783 16452277 SGTC_632 0781-2353 4.65 µM 0.308072527829077 0.357511735581386 no 1204 0.379013572437658 1815 6811515 YHR007C ERG11 SGTC_412 gemfibrozil 100 µM 0.308046019851918 0.357521976875083 no 1205 0.379023657515815 1857 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1221 2958-7315 257 µM 0.307856487825131 0.357595205110182 no 1206 0.379095768219913 1793 4562705 SGTC_2276 7947513 42.08 µM 0.306698312519684 0.358042795451372 no 1207 0.379536507169412 1612 2105100 SGTC_1606 st000094 49.2 µM 0.306294128885458 0.358199042904325 no 1208 0.379690354508916 1927 1242210 SGTC_2109 5483026 200 µM 0.30575038518071 0.358409278311859 no 1209 0.379897353651178 1782 759335 SGTC_75 0159-0059 199.013 µM 0.305736182622753 0.358414770225539 no 1210 0.379902760919722 1871 5377270 SGTC_503 tyrphostin 8 294 µM 0.304931460764262 0.358725991766289 no 1211 0.380209176955107 1871 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_784 4579-0127 173 µM 0.303874710099135 0.359134826477399 no 1212 0.380611672840516 1910 1948547 SGTC_1016 4226-1401 38 µM 0.303800619297084 0.359163496716726 no 1213 0.380639897447882 1752 2901613 SGTC_2315 7733312 200 µM 0.301731915807763 0.359964323674816 no 1214 0.381428218122698 1734 726316 SGTC_3334 9142812 21.919 µM 0.301619305337146 0.360007934604018 no 1215 0.381471144739859 1836 45283678 SGTC_3211 9128781 49.47 µM 0.301459605701923 0.360069784992292 no 1216 0.381532024039849 1690 17194361 SGTC_3144 9087057 49.47 µM 0.3006716447264 0.360375009561871 no 1217 0.381832446520589 1965 17249618 SGTC_1237 0330-0133 46.1 µM 0.300389360666457 0.360484376781581 no 1218 0.381940089073313 1767 X1237 YHR072W ERG7 SGTC_1040 k898-0338 155 µM 0.298889907509601 0.361065511208576 no 1219 0.382512023979706 1961 20969351 SGTC_1982 st072467 71.9 µM 0.298596788530357 0.361179151174622 no 1220 0.382623858051242 1757 3163533 SGTC_2172 5754775 163.918 µM 0.296069959520376 0.362159290379693 no 1221 0.383588327442504 1732 2263357 SGTC_1063 disulfiram 1.84 µM 0.295465470950145 0.362393901560016 no 1222 0.383819162852167 1802 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1844 rapamycin 4 nM 0.295418605327542 0.362412092979019 no 1223 0.383837061101061 1801 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2827 7993847 71.43 µM 0.295049521832525 0.362555367747074 no 1224 0.383978024852829 1802 2985692 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.294335356390713 0.362832654751215 no 1225 0.384250829040698 1771 115019 SGTC_1453 4237-0541 195 µM 0.292310151514438 0.363619366165513 no 1226 0.385024748909463 1914 739892 SGTC_2988 9073640 71.4286 µM 0.290658149468643 0.364261529468565 no 1227 0.385656391081428 1829 9102229 SGTC_990 3985-0011 41.3 µM 0.289426169479609 0.36474067082607 no 1228 0.386127635588698 1792 5399565 YGL099W LSG1 SGTC_2301 7769476 200 µM 0.28900812828383 0.364903303368367 no 1229 0.386287578694408 1825 977820 SGTC_303 1348-1668 34.2 µM 0.288768923140646 0.364996373412197 no 1230 0.386379107587864 1826 5380509 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.288662802794753 0.365037665311195 no 1231 0.386419715252394 1788 689007 SGTC_956 1185-0240 191 µM 0.287487497916771 0.365495086226042 no 1232 0.386869536659744 1812 1416193 SGTC_3195 9113082 49.47 µM 0.286679299445111 0.365809742829712 no 1233 0.38717894461959 1956 17018038 SGTC_1804 st050076 49.1 µM 0.286226771154002 0.365985965505401 no 1234 0.387352220337542 1857 3895976 SGTC_3104 9120930 49.47 µM 0.285602798817783 0.366228997950895 no 1235 0.387591179783217 1812 17014836 SGTC_1188 1403-0014 4.57 µM 0.282860214248308 0.367297848818911 no 1236 0.388641996989739 1808 9614867 SGTC_2620 irigenin 100 µM 0.282621770731087 0.367390824708284 no 1237 0.388733394906661 1885 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1965 Pectolinarigenin 58.4 µM 0.282447907025252 0.367458623999514 no 1238 0.388800042583542 1783 5320438 An anti-inflammatory. SGTC_2477 5967686 25.23 µM 0.282395097580158 0.367479218206812 no 1239 0.388820286828899 1761 776118 SGTC_930 2810-3379 265 µM 0.280410383216392 0.368253477174303 no 1240 0.389581335908947 1954 1015764 SGTC_1414 3917-0015 5.4 µM 0.279826644290364 0.368481302198909 no 1241 0.389805254398843 1883 6618702 SGTC_2107 5363541 170.161 µM 0.279608514365522 0.368566447088077 no 1242 0.389888937024205 1854 244052 SGTC_1874 staurosporine 7.6 µM 0.278982637318171 0.368810787900803 no 1243 0.390129074694288 1900 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_86 0417-1630 471.922 µM 0.278923798508337 0.368833761151915 no 1244 0.390151652236079 1924 3634867 SGTC_1178 0988-0033 191 µM 0.278207930367905 0.369113304977774 no 1245 0.39042637376576 1865 5392207 SGTC_3201 9113999 49.47 µM 0.278151643286641 0.369135287809975 no 1246 0.390447976815926 1867 16649224 SGTC_1420 4'-methoxyflavone 42 µM 0.277624443913301 0.369341205475749 no 1247 0.390650332987074 1934 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2207 7258803 200 µM 0.27697732145435 0.36959401489062 no 1248 0.390898760004378 1888 3666799 SGTC_277 nystatin 15.5 µM 0.276861486379822 0.369639273789298 no 1249 0.390943233201519 1758 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_636 0kpi-0074 126 µM 0.275507146810098 0.370168573082516 no 1250 0.391463317920753 1816 616434 SGTC_1811 st050069 61.5 µM 0.272737861229258 0.371251622422991 no 1251 0.392527364291546 1974 3877702 SGTC_2022 5136654 200 µM 0.272407639802334 0.371380838103746 no 1252 0.39265429951827 1833 1713771 SGTC_866 0495-0101 262 µM 0.272324292110543 0.371413454356638 no 1253 0.392686339699311 1734 635694 SGTC_1373 2887-0003 58.5 µM 0.272160833752203 0.371477422805993 no 1254 0.392749177808778 1819 776948 SGTC_165 k038-0023 64.381 µM 0.270863762892899 0.37198514942521 no 1255 0.393247908251003 1789 46368543 SGTC_393 acivicin 6.25 µM 0.270341842124106 0.372189513454973 no 1256 0.393448638971403 1842 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1513 0337-0559 19 µM 0.270248732705664 0.372225975295764 no 1257 0.393484451831132 1752 775073 SGTC_1337 1486-1011 40.3 µM 0.269819899877159 0.37239392190164 no 1258 0.393649406278552 1933 X1337 SGTC_1463 k081-0032 34.1 µM 0.268471765948344 0.372922058357446 no 1259 0.394168102448364 1833 977755 SGTC_1218 1348-1416 30.7 µM 0.268443889132664 0.372932981727901 no 1260 0.394178830071629 1803 6787668 SGTC_391 gliotoxin 8.33 µM 0.26787844730091 0.373154568909691 no 1261 0.394396442075217 1879 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1296 1068-0102 11.9 µM 0.267319964322194 0.373373470226178 no 1262 0.394611408301453 1918 767053 SGTC_1554 st069299 38.7 µM 0.26640903328349 0.37373060370038 no 1263 0.394962104493963 1886 24207999 SGTC_703 3875-0075 71.8 µM 0.265061033608089 0.374259290259212 no 1264 0.395481222325493 1854 2850814 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.261142501480854 0.375797481738329 no 1265 0.396991308513867 1973 6708630 An antioxidant. SGTC_1687 st020778 55.3625 µM 0.260041796214806 0.376229912157187 no 1266 0.397415766780887 1866 4259299 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.259600393938925 0.376403368093477 no 1267 0.39758601621282 1741 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1394 3474-0001 65.7 µM 0.259021548665911 0.37663087223524 no 1268 0.397809307150476 1828 5017666 YIL048W NEO1 SGTC_3150 9097574 49.47 µM 0.258966270700157 0.376652600432771 no 1269 0.397830632509389 1962 17217476 SGTC_952 1185-0122 232 µM 0.257255511898947 0.377325243970948 no 1270 0.398490766632586 1844 678600 SGTC_524 r073-0010 27.8 µM 0.256044638000192 0.377801565772575 no 1271 0.398958184845379 1794 2772106 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.255950070743546 0.377838773554442 no 1272 0.398994695547836 1927 66535 A nucleotide analog. SGTC_3007 9078383 71.4286 µM 0.255643826299113 0.377959274162127 no 1273 0.3991129370362 1829 6496995 SGTC_2411 st077133 39.94 µM 0.254270643927518 0.378499737761616 no 1274 0.399643238699945 1999 1403142 YNL221C POP1 SGTC_1103 duloxetine 36.1 µM 0.25380285589646 0.378683906328381 no 1275 0.399823933494729 1938 60835 A selective serotonin reuptake inhibitor. SGTC_2650 prasterone 100 µM 0.250943562913063 0.379810210021099 no 1276 0.400928871705 1898 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_364 0083-0097 67.7 µM 0.249233014428639 0.380484500376557 no 1277 0.401590271589311 1849 5207356 SGTC_583 1488-1091 88.9 µM 0.248359738702308 0.380828881864552 no 1278 0.40192804083666 2025 4303273 SGTC_1948 st076329 66.6 µM 0.24835317277377 0.380831471535623 no 1279 0.401930580711839 1952 24208413 SGTC_3133 9127736 49.47 µM 0.247957155323909 0.380987674838067 no 1280 0.402083778411745 2035 27243420 SGTC_113 0099-0221 2.5 µM 0.245900922482806 0.381799037152897 no 1281 0.402879464857575 1966 89219 SGTC_1207 2099-0101 141 µM 0.244952262417537 0.382173541240324 no 1282 0.403246697245316 1993 5837381 SGTC_1143 3454-2408 5.08 µM 0.244705711665043 0.382270890550654 no 1283 0.403342152606183 1894 X1143 SGTC_481 bay k-8644 50 µM 0.244367435038801 0.382404469464747 no 1284 0.40347313021402 1833 2303 A calcium channel antagonist. SGTC_2001 4023502 57.655 µM 0.242714012463751 0.383057575238574 no 1285 0.404113475809802 1897 108941 YCR052W RSC6 SGTC_3137 9097352 49.47 µM 0.242577474625023 0.383111522894071 no 1286 0.404166366364387 1949 44120435 SGTC_2123 5259487 200 µM 0.242223861387065 0.383251250049132 no 1287 0.404303353385877 1958 2173474 SGTC_270 tamoxifen 5.46 µM 0.239447913264242 0.384348667779649 no 1288 0.405379140461183 1995 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3256 9138902 49.47 µM 0.239381089466878 0.384375096752417 no 1289 0.40540504611088 1952 17228773 SGTC_2339 9000433 200 µM 0.239350515779832 0.384387188898496 no 1290 0.405416898781508 1798 2988954 SGTC_1086 cerivastatin 2.18 µM 0.238425662230675 0.384753029252428 no 1291 0.405775482828546 1984 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2993 9054257 71.4286 µM 0.237201143187017 0.385237564871446 no 1292 0.406250374742733 1884 6470217 YGL055W OLE1 SGTC_3010 9080089 71.4286 µM 0.236701138833129 0.385435465486143 no 1293 0.406444325702327 1976 17027233 SGTC_2170 morpholine 200 µM 0.236499885318923 0.385515129604446 no 1294 0.406522398128933 1965 121171 Reacts with secondary amines. SGTC_478 N-arachidonylglycine 10 µM 0.23538552194925 0.385956326130383 no 1295 0.406954761118978 1982 5283389 SGTC_133 0724-0033 378.92 µM 0.233224741159888 0.386812238125099 no 1296 0.407793447426076 1983 280309 SGTC_1522 st012842 45.6 µM 0.233081903824456 0.386868837213962 no 1297 0.407848903303235 1783 3491067 YOR116C RPO31 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.232610418060155 0.387055679842654 no 1298 0.408031968379926 1934 88881 An O-methylated flavonoid and antioxidant. SGTC_340 k038-0059 454 µM 0.231872845121138 0.387348021251193 no 1299 0.408318388115349 1909 23733424 SGTC_3231 9132313 49.47 µM 0.230191956248221 0.388014490013375 no 1300 0.408971306015226 1916 4905967 SGTC_1241 0364-0022 50.8 µM 0.22961738649644 0.388242381438099 no 1301 0.409194547678778 1922 4563895 SGTC_2891 9063876 19.48 µM 0.229540047405358 0.388273059358492 no 1302 0.409224599035441 2060 6472478 SGTC_1049 3226-0134 66 µM 0.228755041109796 0.388584485426651 no 1303 0.409529656107778 1973 5702385 SGTC_3099 9120367 49.47 µM 0.226651218556523 0.389419462243392 no 1304 0.410347480935617 1913 24824940 SGTC_1224 0823-0416 294 µM 0.225949665456508 0.389698012301346 no 1305 0.410620284527866 1997 3598164 SGTC_2005 4024620 188 µM 0.225640337054597 0.3898208484474 no 1306 0.41074058268135 1908 236743 SGTC_2789 5281112 71.43 µM 0.225389098506596 0.389920624867242 no 1307 0.410838295807203 1825 765948 SGTC_3102 9121669 49.47 µM 0.224885738005331 0.390120550359863 no 1308 0.411034082280599 1910 41905072 SGTC_631 k072-0230 41.5 µM 0.224657080649535 0.390211378441801 no 1309 0.411123027884579 1948 5773147 SGTC_1031 k035-0009 16 µM 0.224612887425535 0.390228933721494 no 1310 0.411140219168436 2031 5180959 SGTC_1122 capsaicin 818.572 nM 0.224130886316252 0.390420417970266 no 1311 0.411327729979219 1952 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_595 3909-8003 73.7 µM 0.223553913985044 0.390649666324084 no 1312 0.411552213669638 1939 699517 SGTC_2255 7941087 197.44 µM 0.223094924919262 0.390832063554005 no 1313 0.411730814076812 2032 935561 SGTC_2434 5670830 169.91 µM 0.222001034679287 0.39126686032963 no 1314 0.412156538935767 1905 1549830 SGTC_1483 3453-0561 55.9 µM 0.221851818629073 0.391326180900958 no 1315 0.412214619498165 1984 4546991 SGTC_175 3793-3120 23.7 µM 0.221839713562335 0.39133099335925 no 1316 0.412219331334907 1885 5322297 SGTC_356 1634-0012 32.5 µM 0.221676375064061 0.391395931406624 no 1317 0.412282911266188 2072 735457 SGTC_2778 tioconazole 65.09 nM 0.221193143046139 0.39158806637851 no 1318 0.412471024048329 1924 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2504 purpurogallin 52.29 µM 0.220403666180137 0.391902022405009 no 1319 0.412778395207701 1868 5281571 An antioxidant. SGTC_2710 st078562 53.7235 µM 0.219875857418037 0.392111958579308 no 1320 0.412983919599852 1950 17250908 SGTC_2325 6158266 200 µM 0.219271878042065 0.392352230183351 no 1321 0.413219133464412 1904 3623240 SGTC_2603 homopterocarpin 100 µM 0.218497178384729 0.392660476821869 no 1322 0.413520878268317 1894 101795 A weak amylase inhibitor. SGTC_1557 sumaresinolic acid 42.3 µM 0.218287418477073 0.392743950161454 no 1323 0.413602588354392 1879 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1202 1988-0068 29.6 µM 0.21795720933763 0.392875365913913 no 1324 0.413731225935305 1835 2850480 SGTC_2439 5492030 7.2 µM 0.216171667337075 0.393586182337253 no 1325 0.414426968800081 2037 5722370 SGTC_3042 9091578 49.47 µM 0.215475985220409 0.393863226504057 no 1326 0.414698116668677 2025 25236497 SGTC_1215 3852-0577 11.2 µM 0.21456594825391 0.394225715116479 no 1327 0.415052872462142 2010 2884876 SGTC_2197 6588183 93.1375 µM 0.214185600552614 0.394377243507241 no 1328 0.415201162313334 1954 884136 SGTC_569 4130-2812 160 µM 0.212565159807108 0.395022996877285 no 1329 0.41583307440707 2064 743552 SGTC_3029 9088683 49.47 µM 0.212224017117914 0.395158980681244 no 1330 0.41596613526004 1947 25236615 SGTC_3200 9114385 49.47 µM 0.212157330695087 0.39518556422798 no 1331 0.415992147063181 1870 17018030 YLR208W SEC13 SGTC_2117 5521686 200 µM 0.211990596000416 0.395252032658839 no 1332 0.416057185450988 1870 803312 SGTC_542 3381-0244 89.3 µM 0.211415957735009 0.395481134320338 no 1333 0.416281352842009 2038 1112843 SGTC_379 3970-0972 5.9 µM 0.211351365397612 0.395506888801688 no 1334 0.416306552129704 1954 2898042 YBL034C STU1 SGTC_2367 9070478 135.38 µM 0.210498705596991 0.395846907013357 no 1335 0.416639230907623 1903 572802 SGTC_3086 9117350 49.47 µM 0.209490661603928 0.396248990578254 no 1336 0.417032612311411 1993 2679265 SGTC_992 3909-8734 162 µM 0.208924661606176 0.39647480225608 no 1337 0.417253525896074 1888 4288319 SGTC_2687 chenodiol 100 µM 0.208001485719851 0.396843187515839 no 1338 0.417613903644331 1950 5702181 A cholesterol synthesis inhibitor. SGTC_2726 cimetidine 79.27 µM 0.206403828012104 0.397480936234893 no 1339 0.418237740445438 2055 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2914 7968218 45.32 µM 0.205987044268023 0.397647352006905 no 1340 0.418400515736765 2013 2977111 SGTC_2909 7941780 10.49 µM 0.204895322423635 0.398083349115306 no 1341 0.418826954928595 2075 1243215 SGTC_1971 st069429 63.5 µM 0.204627615969664 0.398190281553731 no 1342 0.418931538752606 2050 1246522 YGL099W LSG1 SGTC_2853 9015042 58.44 µM 0.204489570462921 0.398245425322294 no 1343 0.418985470685355 1936 6457456 SGTC_448 monastrol 171 µM 0.204409452552068 0.398277430219124 no 1344 0.419016772031373 2020 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_910 3454-3003 490 µM 0.200340525643017 0.399903749777958 no 1345 0.420607135032996 2087 820824 SGTC_1231 0242-0792 125 µM 0.199133902269585 0.40038636344207 no 1346 0.421079001043091 1895 3707635 SGTC_1938 st074717 56.4 µM 0.198251420626387 0.400739426366675 no 1347 0.421424178977661 1957 17250979 SGTC_1416 3966-0321 25.3 µM 0.195079977762509 0.402008923544089 no 1348 0.422665168436054 1971 582530 YLR208W SEC13 SGTC_552 k242-0005 476 µM 0.195071810755492 0.402012194057283 no 1349 0.422668365192445 1952 4088318 SGTC_85 0868-0259 160.055 µM 0.192802316479883 0.402921287908116 no 1350 0.423556894619983 1981 83173 SGTC_3223 9129970 49.47 µM 0.191930732430173 0.403270559114746 no 1351 0.423898231975069 1969 17248386 SGTC_835 0312-0010 67.2 µM 0.190082466158632 0.40401147271694 no 1352 0.424622254784999 1947 1626196 SGTC_934 2950-0684 338 µM 0.189730760129753 0.404152500036596 no 1353 0.424760057751015 2082 1121253 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.186436880418166 0.405473884419668 no 1354 0.426051086502924 2063 6728940 SGTC_1784 st039334 36.3 µM 0.186279205984683 0.405537164807116 no 1355 0.426112906640693 2089 3496984 SGTC_361 000s-0510 1.45 µM 0.186155440578976 0.4055868380191 no 1356 0.426161433182631 1965 660 SGTC_1407 3909-7909 12.3 µM 0.185490944406866 0.40585355935475 no 1357 0.426421991170128 1975 4411780 SGTC_2879 9041815 71.43 µM 0.183725858600577 0.406562257007857 no 1358 0.427114260990947 2091 4942971 SGTC_2927 9011802 47.9 µM 0.183149898345861 0.406793576537195 no 1359 0.427340202325036 1903 43912568 SGTC_3277 9138724 49.47 µM 0.182929585002785 0.406882068293227 no 1360 0.427426634544007 2005 15943418 SGTC_986 1493-0483 84 µM 0.181669030480211 0.407388477912756 no 1361 0.427921235795005 2093 40079 SGTC_555 4296-0685 37 µM 0.180537978293971 0.407842993646132 no 1362 0.42836512091594 2052 2908540 YHR072W ERG7 SGTC_394 menadione 8.33 µM 0.180149911312443 0.407998967805523 no 1363 0.428517439983439 2094 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3296 9122258 64.045 µM 0.179603258705375 0.408218706361101 no 1364 0.42873202310467 1971 4730474 SGTC_187 1488-2104 32.728 µM 0.178287295505411 0.408747803809221 no 1365 0.42924867784554 2072 2852859 SGTC_1264 0783-0040 158 µM 0.177624621398177 0.409014302242964 no 1366 0.429508893470533 1943 2855798 SGTC_1860 st056228 74.6 µM 0.177288991033309 0.409149294096508 no 1367 0.429640698852167 1966 688679 SGTC_2518 prenyletin 46.28 µM 0.17679009827143 0.409349970636143 no 1368 0.42983663349 2090 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2560 caryophyllene 100 µM 0.176505966366279 0.409464271565608 no 1369 0.429948230893658 2088 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1709 st033179 39.1045 µM 0.175223622338509 0.40998023010085 no 1370 0.430451961765659 2075 573381 SGTC_1344 1488-0097 29.1 µM 0.175163967255152 0.410004236470395 no 1371 0.430475398260088 2025 747966 SGTC_2476 5806916 10.51 µM 0.174885316203228 0.410116375557069 no 1372 0.430584874215529 2028 2870194 SGTC_290 2043-6722 48.1 µM 0.173320844164966 0.410746110948096 no 1373 0.431199620180235 2056 773758 YLR208W SEC13 SGTC_2958 9077254 16.72 µM 0.17236528103557 0.411130860043356 no 1374 0.431575182678971 1991 16457351 SGTC_670 4204-0025 119 µM 0.171973225074763 0.411288742687381 no 1375 0.431729289333025 2055 719039 SGTC_879 0831-1030 162 µM 0.171828612765582 0.411346982323246 no 1376 0.431786135166904 1940 1549252 SGTC_2977 9011197 71.43 µM 0.171793354586217 0.411361182126738 no 1377 0.431799995063051 2074 2704722 SGTC_861 0443-0273 110 µM 0.17150295540319 0.411478141285576 no 1378 0.431914153398078 2042 6149169 SGTC_1540 guanosine 70.6 µM 0.171436156917084 0.411505045693373 no 1379 0.431940413243423 2096 6802 Guanosine is a purine nucleoside SGTC_2095 5432005 200 µM 0.169045808346626 0.412468078670083 no 1380 0.432880305002963 2012 783734 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.167921187645242 0.412921352985551 no 1381 0.433322640737662 1951 2374 Ca(2+)-ATPase inhibitor. SGTC_312 4092-0653 6.84 µM 0.167277911969821 0.413180675171526 no 1382 0.433575691474885 2078 1148278 SGTC_2399 5884133 200 µM 0.167216334865217 0.413205500591103 no 1383 0.433599916005692 1962 722445 SGTC_1316 1272-0050 65.9 µM 0.167094779774935 0.413254507748253 no 1384 0.433647736703485 2032 7340392 SGTC_2131 toluylene red 5.2905 µM 0.166167969380046 0.413628212691957 no 1385 0.434012382854063 1956 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_421 streptovitacin 30 mM 0.165826051739148 0.413766099191742 no 1386 0.434146921817796 1967 91467 include heat shock SGTC_2137 5261020 140 µM 0.165706486030794 0.41381431944515 no 1387 0.434193970756981 2008 763655 SGTC_1559 coumarin 343 70.1 µM 0.165143496977233 0.414041387574909 no 1388 0.434415518680468 2089 108770 A hepatotoxic, DNA x-linker. SGTC_1034 k072-0165 12.7 µM 0.164442095331763 0.414324321301602 no 1389 0.43469156365336 2114 5835461 SGTC_644 1498-1197 63.3 µM 0.164386331379541 0.41434681745997 no 1390 0.434713511589136 2076 6741615 SGTC_1735 st034310 56.75 µM 0.164219043902969 0.414414305853645 no 1391 0.43477935487936 2045 871153 SGTC_1674 st016616 23.6 µM 0.163339959199643 0.414768994413141 no 1392 0.435125386731567 1920 625830 SGTC_2798 7813637 45.45 µM 0.162643718048825 0.415049959531433 no 1393 0.435399481621151 2045 956368 SGTC_2049 5262831 67.185 µM 0.161601576667241 0.415470592355681 no 1394 0.43580980781673 2006 763417 SGTC_3319 9138450 16.7555 µM 0.155946319823507 0.417754864766137 no 1395 0.438037666988931 1995 2029690 SGTC_237 nikkomycin 200 µM 0.155855508833612 0.417791568024257 no 1396 0.438073457730025 2129 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_887 0885-0007 9.62 µM 0.155034073928713 0.418123601498471 no 1397 0.438397227472831 2112 5719458 SGTC_2076 5212012 200 µM 0.155022621934122 0.418128230939969 no 1398 0.43840174158482 2118 604802 SGTC_226 1,3-diallylurea 8.28947 mM 0.153613320248732 0.418698024180172 no 1399 0.438957316782908 2087 74537 YKL182W FAS1 SGTC_3192 9110362 49.47 µM 0.153465999811621 0.418757597016865 no 1400 0.439015400438604 2093 16649480 SGTC_2828 7998861 71.43 µM 0.152989622600374 0.418950245234145 no 1401 0.439203229457961 2152 2988188 SGTC_2868 9035608 32.47 µM 0.151594916353772 0.419514379754373 no 1402 0.439753221613859 2126 6462614 SGTC_157 1348-1695 65.819 µM 0.15081937656402 0.419828143828262 no 1403 0.440059100409727 2129 5380510 SGTC_850 0388-0143 75.9 µM 0.150170006188377 0.420090902116378 no 1404 0.440315244557729 2016 67273 SGTC_138 0850-0259 40.9225 µM 0.149914111050463 0.420194456156947 no 1405 0.440416189263316 2147 6813004 SGTC_3261 9137475 49.47 µM 0.149890484623968 0.420204017429836 no 1406 0.440425509536777 2156 17027690 SGTC_2433 5607874 27.82 µM 0.149802101773567 0.420239785107869 no 1407 0.440460375547906 2077 2252428 SGTC_2713 st079149 53.4 µM 0.146930191182229 0.42140237612867 no 1408 0.441593560708258 2060 3103253 SGTC_720 r052-1644 49.9 µM 0.14656326744222 0.421550961775732 no 1409 0.441738374423442 2063 1422863 YOR257W CDC31 SGTC_2654 protoveratrine a 100 µM 0.146333929559861 0.421643837749681 no 1410 0.441828891113442 2124 5702278 A heart drug and vasodilator. SGTC_914 3820-6779 408 µM 0.144034380154019 0.42257533655874 no 1411 0.44273666062449 2095 2893481 SGTC_3266 9136860 49.47 µM 0.143266052931706 0.422886666456481 no 1412 0.443040032529907 2119 4871271 YPR165W RHO1 SGTC_2474 5321570 43.32 µM 0.14280226650404 0.423074618280665 no 1413 0.443223173508971 2135 2841384 SGTC_3291 9121177 71.43 µM 0.14228411754554 0.423284621505337 no 1414 0.44342779562479 2038 17015612 SGTC_51 1013-0126 23.419 µM 0.142247266130289 0.423299558033628 no 1415 0.443442349186094 2198 1627850 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.139203201095606 0.424533749924695 no 1416 0.444644789512678 2040 5282362 SGTC_471 1-acyl-paf 4 µM 0.138641307758252 0.424761646390434 no 1417 0.444866799817342 2029 16759367 SGTC_1849 st056239 19.2 µM 0.138044552444881 0.425003709948655 no 1418 0.445102603413322 1951 5393181 SGTC_1357 1503-1303 39.5 µM 0.137505966197541 0.425222202504671 no 1419 0.445315438598964 2118 292895 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.134811674444588 0.426315560770847 no 1420 0.44638038761654 2066 688664 SGTC_416 estradiol valerate 100 µM 0.134792121900143 0.426323497380702 no 1421 0.446388117402089 2063 13791 A steroid. SGTC_2793 7325131 81.82 µM 0.134240951044797 0.426547236436422 no 1422 0.446606022349893 2092 4176441 SGTC_2499 avocadenofuran 51.48 µM 0.133857490458842 0.426702910120198 no 1423 0.446757632694178 2135 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_285 1486-1325 46 µM 0.13136379812294 0.427715553146023 no 1424 0.4477437626803 2160 22310230 SGTC_1924 st058459 75.1 µM 0.130911620140389 0.427899225599065 no 1425 0.447922611126525 2193 688683 SGTC_1135 dihydrocapsaicin 536.708 nM 0.130221462910872 0.428179594151022 no 1426 0.448195607108463 2070 107982 A Capsaicinoid. SGTC_2899 9053889 58.44 µM 0.130199458377709 0.428188533840415 no 1427 0.448204311542627 2208 6470052 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.129855660477093 0.428328211954891 no 1428 0.44834031249186 2185 756377 SGTC_3028 9087778 49.47 µM 0.128128607365134 0.429030014114684 no 1429 0.449023598613528 2142 17217395 SGTC_207 4185-0010 4.486 µM 0.127330140500789 0.429354553653892 no 1430 0.449339552891639 2176 3761753 SGTC_2349 9023730 187.07 µM 0.126916803862474 0.429522574492272 no 1431 0.449503123317536 2146 4126287 SGTC_380 3970-0968 6 µM 0.126655825454039 0.429628668474021 no 1432 0.449606405177654 2101 2891601 SGTC_2867 9039098 71.43 µM 0.126538307129037 0.429676444151486 no 1433 0.449652914014606 2170 6463460 SGTC_838 0109-0203 71.4 µM 0.12613130108136 0.42984191557562 no 1434 0.449813995323732 2169 759422 SGTC_1283 0922-0125 16.4 µM 0.125167350220108 0.430233866286699 no 1435 0.450195532339021 2148 3360884 SGTC_61 0978-8327 98.565 µM 0.12456597219447 0.430478426615554 no 1436 0.450433584387685 2198 6150059 YHR072W ERG7 SGTC_1366 1683-0113 21.9 µM 0.124185509143631 0.430633161991774 no 1437 0.450584197723722 2123 708623 SGTC_741 4582-0002 126 µM 0.124055329310452 0.430686108937146 no 1438 0.450635733453724 2078 2912688 SGTC_2576 guaiol 23.12 µM 0.123721020301997 0.430822085326255 no 1439 0.450768083868494 2194 227829 SGTC_855 0428-0020 25 µM 0.123561498546165 0.430886971878558 no 1440 0.450831239258549 2055 6812414 SGTC_2966 9084041 48.03 µM 0.122905808541623 0.431153697795156 no 1441 0.451090842976267 1973 17741380 SGTC_2756 carbadox 75.1 µM 0.122470475155974 0.431330802941381 no 1442 0.451263213679731 2073 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_842 0271-0008 11.1 µM 0.122073475261683 0.431492325046192 no 1443 0.451420414210563 2147 1221709 SGTC_2594 a-mangostin 100 µM 0.121884196880092 0.431569338276596 no 1444 0.451495365685024 2171 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1304 1165-0502 251 µM 0.120941398721208 0.431952980901018 no 1445 0.451868725689942 2133 767425 SGTC_935 2996-0153 430 µM 0.119864875818778 0.432391117147309 no 1446 0.452295094427484 2213 23738523 SGTC_1042 0350-0096 82 µM 0.119221073996429 0.432653179128676 no 1447 0.452550105543855 1996 3122515 SGTC_1742 st038235 28.8875 µM 0.119156883357482 0.432679309798582 no 1448 0.452575532651869 2089 564103 YBR002C RER2 SGTC_748 act1.228 77.9 µM 0.118268641395369 0.433040924744349 no 1449 0.45292740176197 2093 4421505 YNR035C ARC35 SGTC_2676 harmalol 100 µM 0.117406031537623 0.433392158199527 no 1450 0.45326915232715 2170 5459187 A monoamine oxidase inhibitor SGTC_37 0566-0070 1.56 µM 0.116217111217328 0.433876343403031 no 1451 0.453740237926685 2177 1626686 SGTC_674 0498-0004 451 µM 0.113721211875418 0.43489311494291 no 1452 0.454729398480033 2052 4231473 SGTC_1689 st020265 53.493 µM 0.112967551706831 0.435200223599056 no 1453 0.455028140242822 2202 5758320 YPR016C TIF6 SGTC_983 1491-0821 12.2 µM 0.111583620091759 0.435764262963763 no 1454 0.455576780088967 2208 46495113 SGTC_2618 avocadyne 43.43 µM 0.111463072937703 0.435813399731266 no 1455 0.455624573306372 2128 3015189 SGTC_2800 7887935 81.82 µM 0.111358022536034 0.435856220605837 no 1456 0.455666223064534 2120 2961002 SGTC_1445 4239-0156 97.7 µM 0.110681916183053 0.436131834529321 no 1457 0.455934293327595 2200 4008346 SGTC_2154 5570129 200 µM 0.110599327160008 0.436165503971476 no 1458 0.455967040531179 2206 673366 SGTC_774 k060-0086 136 µM 0.109963067274867 0.436424906419886 no 1459 0.456219332641268 2222 5911235 SGTC_2356 9061756 188.97 µM 0.108859882597967 0.436874738332306 no 1460 0.456656813265771 2199 20104043 SGTC_1343 1487-0095 224 µM 0.108555548522867 0.436998847248496 no 1461 0.456777509726952 2218 4560101 YGL055W OLE1 SGTC_1861 st057647 17.4 µM 0.107996487810538 0.437226851075076 no 1462 0.456999239118632 2205 688668 SGTC_3027 9089541 49.47 µM 0.106711610121446 0.437750946463445 no 1463 0.457508885829609 2133 9943819 SGTC_1562 morin hydrate 59.1 µM 0.106615322401717 0.437790226168734 no 1464 0.457547081176864 2128 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_803 4488-1585 147 µM 0.10527512283542 0.43833701194941 no 1465 0.458078751184043 2201 747204 SGTC_3311 9131146 2.8755 µM 0.104916062963221 0.438483524225789 no 1466 0.458221206455962 2117 4900406 YPR165W RHO1 SGTC_3132 9126706 49.47 µM 0.103619565553213 0.439012622435128 no 1467 0.458735630089763 2148 850858 SGTC_1610 st001799 48.1 µM 0.102009066938699 0.439670015639576 no 1468 0.459374739126628 2056 621897 SGTC_1936 st074407 74.3 µM 0.101267024831 0.439972967651005 no 1469 0.459669245984225 2190 809813 SGTC_123 0083-0120 66.675 µM 0.100354805243156 0.440345445821733 no 1470 0.460031324379321 2061 16001701 SGTC_2383 9036125 200 µM 0.100256721687595 0.440385498520372 no 1471 0.460070257704274 2124 79580 SGTC_1020 4335-0961 93.3 µM 0.0993719312222644 0.440746832741953 no 1472 0.460421484037357 2030 669075 SGTC_196 k015-0023 18.111 µM 0.0983812848481733 0.441151455351114 no 1473 0.460814767553816 2092 5211998 SGTC_2201 6605497 169.863 µM 0.0973691604989466 0.441564913935282 no 1474 0.461216617343762 2209 670741 SGTC_3033 9090887 49.47 µM 0.0961966235782366 0.442043981568271 no 1475 0.461682206187299 2162 19325384 SGTC_3073 9114972 49.47 µM 0.0958607393916762 0.442181230632204 no 1476 0.461815588178516 2252 41905075 SGTC_2614 arthonioic acid 13.39 µM 0.0923603713606177 0.443611961754812 no 1477 0.463205861938216 2247 6710684 SGTC_2753 fluvastatin 17.09 µM 0.0910148129505572 0.44416213840882 no 1478 0.463740410438214 2174 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2969 9091408 28.7 µM 0.0909964804148037 0.44416963502602 no 1479 0.463747693838637 2015 4286311 SGTC_2032 5185112 25.99 µM 0.0908791712317321 0.444217606060581 no 1480 0.463794300322111 2222 5718189 SGTC_2388 9080168 200 µM 0.0891301579464122 0.444932923478285 no 1481 0.464489235096586 2218 15943073 SGTC_2777 climbazole 1.536 µM 0.0888181488996884 0.445060548920608 no 1482 0.464613216979089 2266 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1766 st045414 44.774 µM 0.0876397617301725 0.445542612434862 no 1483 0.465081499228961 2256 253960 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0870020835465973 0.445803512261705 no 1484 0.465334927979317 2167 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3321 9137793 26.8275 µM 0.0869074385031663 0.445842237363651 no 1485 0.46537254341201 2266 4904192 SGTC_2334 9017922 200 µM 0.0866513951871435 0.445947003003101 no 1486 0.46547430602364 2226 3163164 SGTC_3012 9080433 71.4286 µM 0.0866088088824032 0.445964428473497 no 1487 0.465491231869526 2246 17688859 SGTC_641 4092-0595 30 µM 0.0857228516446061 0.446326968206878 no 1488 0.465843368003221 2219 786260 SGTC_964 1287-0107 19.4 µM 0.0853856353219047 0.446464971228148 no 1489 0.465977406403661 2226 51516812 YPR165W RHO1 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0850065448450446 0.44662011864563 no 1490 0.466128093755964 2231 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1899 st063254 59.6 µM 0.0848226139978095 0.446695397541566 no 1491 0.466201207479033 2223 3093813 SGTC_346 4513-0042 7.16 µM 0.0847019408563202 0.446744787477872 no 1492 0.466249176467323 2245 2827372 SGTC_3126 9127922 49.47 µM 0.0838767229982281 0.447082560439276 no 1493 0.466577223343968 2187 45595682 SGTC_1977 st070720 65.3 µM 0.0825931020343774 0.447608040273488 no 1494 0.467087543157462 2129 682188 SGTC_21 0849-0113 22.993 µM 0.0822078546780934 0.447765768145487 no 1495 0.46724071372992 2226 1560156 SGTC_1937 st074714 47.2 µM 0.080684748806898 0.448389438396473 no 1496 0.467846332978616 2253 17250970 SGTC_1779 st039427 55 µM 0.0787638165788 0.449176189404072 no 1497 0.468610242394128 2286 1124498 SGTC_1728 st035614 33.7865 µM 0.0782037860999646 0.449405597335802 no 1498 0.468832975185721 2135 15945546 SGTC_3061 glucosamine 200 µM 0.0777276935263259 0.449600634690013 no 1499 0.469022332247192 2256 91431 and experimental redox chemotherapeutic SGTC_1801 st050089 28.441 µM 0.0772242745894539 0.449806879878722 no 1500 0.469222565488216 2263 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1968 st069590 43.6 µM 0.0753790814502403 0.450562950676119 no 1501 0.469956551217637 2253 6384066 SGTC_2149 5554786 194.827 µM 0.0742445338632397 0.45102792259876 no 1502 0.470407905355239 2196 745063 YPR165W RHO1 SGTC_1085 doxorubicin 7.67 µM 0.0735362993098054 0.451318212656366 no 1503 0.470689679791137 2289 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_301 4119-0100 24.5 µM 0.0727465762106747 0.451641933805479 no 1504 0.471003892125852 2222 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_444 curcumin 90.4 µM 0.0710221926280906 0.45234889992588 no 1505 0.471690046462771 2260 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_332 4112-0506 40.9 µM 0.0709294867791874 0.452386911949513 no 1506 0.471726937707293 2262 2790355 SGTC_2015 5119600 184 µM 0.0705758052704824 0.452531935390397 no 1507 0.471867683490679 2258 2828786 SGTC_710 3448-4187 58 µM 0.0702910667217607 0.452648694086654 no 1508 0.471980996322321 2267 3946412 SGTC_3107 9121808 49.47 µM 0.0697279227881159 0.452879626575847 no 1509 0.472205108347494 2280 662681 SGTC_423 5-fluorouracil 457 µM 0.0694899453260515 0.452977220503177 no 1510 0.472299817887521 2255 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3240 9133527 49.47 µM 0.0690550884216413 0.45315556150192 no 1511 0.472472884945842 2263 17617455 SGTC_508 roscovitine 141 µM 0.0690270770221998 0.453167049699366 no 1512 0.472484033275514 2292 160355 A CDKinase inhibitor. SGTC_2145 5634607 200 µM 0.0687957486273973 0.453261924938604 no 1513 0.472576101087898 2234 308662 SGTC_1665 st014639 11.4 µM 0.0686615176540955 0.453316978615637 no 1514 0.472629525171657 2289 981133 YIL048W NEO1 SGTC_367 0335-0881 7.1 µM 0.06856133917078 0.453358066542065 no 1515 0.472669396645644 2238 23828853 SGTC_279 1273-0055 2.93 µM 0.0679378800362261 0.453613787778939 no 1516 0.472917542244742 2286 2847562 SGTC_3273 9137859 49.47 µM 0.0647201122901971 0.454933907598059 no 1517 0.474198424550677 2324 2377234 SGTC_1994 st072947 40.9 µM 0.0638768345346512 0.455279953243099 no 1518 0.474534148982076 2202 5286565 YDL195W SEC31 SGTC_660 4031-1742 102 µM 0.0637747667845835 0.455321839852791 no 1519 0.474574785267986 2264 6738706 SGTC_1185 1319-0113 81.3 µM 0.0636285257922737 0.455381855163235 no 1520 0.474633008730484 2224 4672763 SGTC_638 3970-0837 4.09 µM 0.0632885833634199 0.455521366835943 no 1521 0.474768353347483 2243 4118451 YLR208W SEC13 SGTC_2634 4'-methoxyflavone 100 µM 0.0626550213471203 0.455781394007106 no 1522 0.475020607372577 2225 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1955 wogonin 32.4 µM 0.0602077587148884 0.456785978946303 no 1523 0.475995083183194 2267 5281703 A flavanone. SGTC_497 capsazepine 133 µM 0.0580245273948839 0.457682414145801 no 1524 0.476864545700825 2288 2733484 A calcium channel blocker. SGTC_2225 6654152 15.4 µM 0.0573985560467465 0.457939478021233 no 1525 0.477113856607757 2293 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1036 k216-0215 33.5 µM 0.0563551845130517 0.45836799216472 no 1526 0.477529428880321 2322 622330 SGTC_1800 st050079 29.0735 µM 0.0562237988813352 0.458421955867399 no 1527 0.477581761190462 2286 3645560 SGTC_1444 4112-3581 28 µM 0.0548578407404987 0.458983037765556 no 1528 0.478125859743443 2280 2877249 SGTC_543 3844-1095 191 µM 0.0547499892192754 0.459027342425446 no 1529 0.478168821709307 2269 4230703 SGTC_44 0929-0055 61.211 µM 0.0511726800124457 0.460497161399624 no 1530 0.479593960752594 2268 1379590 SGTC_2788 5282734 71.43 µM 0.0509457555642341 0.460590416900055 no 1531 0.479684372578611 2294 743706 SGTC_2019 4016004 108 µM 0.0508527825990125 0.460628625134465 no 1532 0.479721415410176 2262 45595336 SGTC_1150 3909-7983 10.9 µM 0.0504282716783425 0.460803087051209 no 1533 0.479890553750047 2277 23965914 SGTC_65 0798-0905 34.986 µM 0.0494409810346592 0.461208864552266 no 1534 0.480283934967524 2307 3602145 SGTC_3356 9151811 4.48 µM 0.0493953747390643 0.461227609767298 no 1535 0.480302107044009 2301 1859254 YPR165W RHO1 SGTC_2097 5376186 200 µM 0.0478838410253792 0.461848932669619 no 1536 0.480904408805621 2317 742755 SGTC_3182 9108849 49.47 µM 0.0475346518048312 0.461992481804633 no 1537 0.481043556696423 2264 17133045 SGTC_1917 st066507 28.5 µM 0.0471596763999438 0.462146636963968 no 1538 0.481192982656648 2237 3156428 SGTC_295 k015-0027 31 µM 0.0462567010037865 0.462517880110117 no 1539 0.48155282496809 2271 3887424 SGTC_708 3448-5400 146 µM 0.0416629623677695 0.46440701730203 no 1540 0.483383690028943 2334 3462195 SGTC_2327 6189656 200 µM 0.0406512471743575 0.464823186189226 no 1541 0.483786964278861 2325 5349088 SGTC_1611 st001856 99.4 µM 0.0395502650290384 0.465276118734416 no 1542 0.484225839571313 2307 647478 SGTC_706 4262-0057 46.9 µM 0.0386974708547063 0.465626980293429 no 1543 0.484565794933118 2338 883298 SGTC_2708 st078559 56 µM 0.0384363980693122 0.465734397738216 no 1544 0.48466987047497 2330 17250902 SGTC_1468 k284-1086 134 µM 0.0383484329443074 0.465770591230566 no 1545 0.484704937628899 2321 15996457 SGTC_1124 fisetin 1.16336 µM 0.0375594679146368 0.466095225681785 no 1546 0.485019462510324 2226 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_656 4090-1979 187 µM 0.0365753328633969 0.466500198094818 no 1547 0.485411805945055 2353 22330961 SGTC_154 3389-1638 511.116 µM 0.0355382777756994 0.466926984673991 no 1548 0.485825262194922 2145 5238686 SGTC_1987 st072290 61.9 µM 0.0339683018674882 0.46757316011247 no 1549 0.486451213776119 2248 54697379 SGTC_470 aa-861 153 µM 0.0336285963519903 0.467712988441754 no 1550 0.486586659284305 2334 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2810 7959871 45.46 µM 0.0336138605229387 0.467719054039548 no 1551 0.48659253470786 2313 2974535 SGTC_1816 st051957 91.6 µM 0.0332953248596136 0.467850172293769 no 1552 0.486719540958031 2353 674121 SGTC_661 1304-0007 33.6 µM 0.0328723965444599 0.468024266892534 no 1553 0.486888172630801 2329 3117130 SGTC_1519 esterone 74 µM 0.0317018926550525 0.468506125968579 no 1554 0.487354892763154 2318 698 A steroid. SGTC_2050 5263056 171 µM 0.0316887229795154 0.468511547767295 no 1555 0.487360144065173 2343 763468 YGL055W OLE1 SGTC_2929 9013348 24.6 µM 0.0309496039203803 0.468815843621339 no 1556 0.487654865321389 2340 2995952 SGTC_2862 9027634 71.43 µM 0.0308987897007089 0.468836764543843 no 1557 0.487675127571288 2324 5012562 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0306582691111223 0.468935791389678 no 1558 0.487771035964922 2323 521171 SGTC_3271 9137798 49.47 µM 0.0301010114048775 0.469165232231704 no 1559 0.487993247056672 2345 6498326 SGTC_1273 0849-0096 14.1 µM 0.0296639079458669 0.469345208892804 no 1560 0.488167548266493 2318 5286025 SGTC_3285 9112818 20.8695 µM 0.0289170772216406 0.469652729741769 no 1561 0.488465362831902 2357 17017947 YPR165W RHO1 SGTC_2244 6635614 200 µM 0.028402196704924 0.469864751516171 no 1562 0.488670686096114 2323 836499 SGTC_3003 9075612 71.4286 µM 0.0281341719797739 0.469975124348436 no 1563 0.488777569777463 2324 6501993 SGTC_1548 st061468 90.8 µM 0.0280893196486953 0.469993594805843 no 1564 0.488795456199753 2348 390799 SGTC_1094 duloxetine 25.4 µM 0.0272755806726508 0.470328708540961 no 1565 0.489119966710604 2364 60834 A selective serotonin reuptake inhibitor. SGTC_2880 9042983 58.44 µM 0.02632099089361 0.470721854179358 no 1566 0.489500656199188 2328 6464714 SGTC_675 1309-0189 238 µM 0.0262631924287957 0.470745659266291 no 1567 0.489523706482133 2335 4246530 SGTC_3229 9132204 49.47 µM 0.0262073976775086 0.470768639195614 no 1568 0.489545957708469 2342 17682924 SGTC_1253 0550-0034 176 µM 0.0258919298373098 0.470898571322631 no 1569 0.489671768473619 2316 5969915 SGTC_3302 9125395 16.351 µM 0.0258087578883634 0.470932827972074 no 1570 0.489704938196064 2296 17599668 SGTC_785 1270-0111 65.3 µM 0.0252230155042788 0.471174088122814 no 1571 0.489938539538481 2369 6741994 SGTC_1802 st050112 57.9 µM 0.0249317746612091 0.471294050620739 no 1572 0.490054691295897 2353 4662563 SGTC_1983 st071813 46.9 µM 0.0241936777504703 0.471598085378784 no 1573 0.490349060540016 2254 11838595 SGTC_769 0302-0231 76 µM 0.0241433026611982 0.471618836346179 no 1574 0.490369151424444 2356 571869 YER009W NTF2 SGTC_1395 3486-0190 4.35 µM 0.0238113351804128 0.471755585350537 no 1575 0.490501549223639 2370 6748079 SGTC_505 gw-5074 63.9 µM 0.0237585179130185 0.471777342935882 no 1576 0.490522614305395 2349 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_343 4130-2827 29.8 µM 0.0233656746907821 0.471939173710576 no 1577 0.490679292577545 2333 1118244 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0232308913967061 0.471994698417447 no 1578 0.490733048740532 2356 688669 SGTC_3097 9117246 49.47 µM 0.0228609438090725 0.472147103120749 no 1579 0.490880597286155 2364 16423892 SGTC_971 1315-0384 26.7 µM 0.0208754341903236 0.472965128667552 no 1580 0.491672511514832 2352 6769120 SGTC_2251 lansoprazole 556 µM 0.0196914570873874 0.473452979094493 no 1581 0.492144752858317 2337 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3093 9117344 49.47 µM 0.0190660868769876 0.473710675130494 no 1582 0.49239419263078 2346 24824913 SGTC_905 2-aminofluorene 215 µM 0.018677524996471 0.473870795207157 no 1583 0.49254917879126 2376 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3015 9080845 49.47 µM 0.0185694231957634 0.473915342965341 no 1584 0.492592297691935 2362 5296973 SGTC_1842 st055362 61.2 µM 0.0168669458780319 0.474616960874417 no 1585 0.493271381191316 2366 676032 SGTC_1506 4226-2149 212 µM 0.0165573521289162 0.474744557893513 no 1586 0.493394873980373 2305 991114 SGTC_3278 9139605 49.47 µM 0.016436983350274 0.474794167790801 no 1587 0.493442887641324 2357 7958859 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0155056108966705 0.475178045367071 no 1588 0.493814404091778 2362 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2936 9038235 15.59 µM 0.0154308602214366 0.475208855858306 no 1589 0.493844221729219 2381 4749415 SGTC_2458 5808907 16.39 µM 0.0136558079281135 0.475940534312925 no 1590 0.494552290160772 2382 2731747 SGTC_3174 9107204 49.47 µM 0.0130031442241766 0.476209583521145 no 1591 0.494812642172495 2378 3938802 SGTC_2043 5101342 149 µM 0.012391118649954 0.476461890227332 no 1592 0.495056785366102 2364 678451 SGTC_1242 0402-0103 60.1 µM 0.0123042226567354 0.476497713749125 no 1593 0.495091449209172 2386 432868 SGTC_694 1315-0438 43.2 µM 0.0117292377946339 0.476734760323321 no 1594 0.495320818416833 2375 6793154 SGTC_2014 4013930 200 µM 0.00970551002950393 0.47756913892216 no 1595 0.496128122482959 2391 64556 SGTC_3350 9150499 3.57 µM 0.00969205672009085 0.477574686025736 no 1596 0.496133489324469 2396 4910996 YPR165W RHO1 SGTC_1789 tunicamycin 25 nM 0.00892250668345694 0.477891996100027 no 1597 0.496440482066406 2382 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1179 1021-1431 9.29 µM 0.00879882768850941 0.47794299421482 no 1598 0.496489820909787 2370 2840958 SGTC_2124 5246320 200 µM 0.00769819536866058 0.478396847587729 no 1599 0.496928894718096 2385 579342 SGTC_3082 9117008 49.47 µM 0.00750498206541269 0.478476523341175 no 1600 0.497005973446781 2384 41448529 SGTC_2649 anisomycin 9.56 µM 0.00733977956789512 0.478544648905345 no 1601 0.497071877892374 2379 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_815 1582-0027 36.9 µM 0.00588012174094314 0.479146603942674 no 1602 0.497654184341726 2388 3128206 SGTC_2845 9003024 42.97 µM 0.00563350559793396 0.479248311848474 no 1603 0.497752568317672 2394 2990173 SGTC_2089 5281248 129.67 µM 0.0050396333243001 0.479493238513936 no 1604 0.497989485699695 2395 2737878 SGTC_3148 9097893 49.47 µM 0.00444502014818751 0.479738478502521 no 1605 0.498226699365193 2388 17174100 SGTC_2829 7992743 58.44 µM 0.00403952008502996 0.479905725805146 no 1606 0.498388469028304 2401 16462845 SGTC_1666 st014829 29 µM 0.00375297655526856 0.480023911972048 no 1607 0.498502782489425 2397 3858230 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.00328839559129689 0.480215534206232 no 1608 0.498688122328288 2393 688788 SGTC_2960 9079389 5.97 µM 0.00237039127677468 0.480594189978186 no 1609 0.499054351584161 2403 16457355 SGTC_1846 st056244 14.8 µM 0.00225356730206197 0.480642378457445 no 1610 0.499100957482452 2376 5393182 SGTC_1651 st011928 86.1 µM 0.000990604699009819 0.481163353197538 no 1611 0.499604805967034 2401 720198 SGTC_1765 st044815 90.4 µM 0.000157230369239378 0.48150713954208 no 1612 0.499937274158206 2403 645695 SGTC_1167 k781-0610 148 µM 0 0.481572002285753 no 1613 0.5 2404 4525169 SGTC_1904 st060225 78 µM -0.000481575526265271 0.481770671195311 no 1614 0.499807879168792 2403 66595 SGTC_3176 9106582 49.47 µM -0.000622222272579164 0.48182869438503 no 1615 0.499751769243678 2408 17018027 SGTC_2292 7671323 168.05 µM -0.000709063915619866 0.481864520710957 no 1616 0.499717124448256 2408 937504 SGTC_1886 st057356 49.9 µM -0.00346288362431466 0.483000677308229 no 1617 0.498618512071185 2415 24207747 SGTC_2342 7990637 118.86 µM -0.0048201525776119 0.48356070363061 no 1618 0.49807704478509 2414 2033102 YER133W GLC7 SGTC_974 1326-0144 138 µM -0.00495022464407079 0.483614374729521 no 1619 0.498025154157507 2418 5411856 SGTC_1868 st057644 42.7 µM -0.00632585929204729 0.484182015150402 no 1620 0.497476364099721 2423 688665 SGTC_1619 st003326 88.7 µM -0.00860509440782048 0.485122586319097 no 1621 0.496567106380211 2422 2849032 SGTC_3345 9148410 3.559 µM -0.00905659108662585 0.485308915286893 no 1622 0.49638699229023 2423 4903596 SGTC_564 3555-0129 330 µM -0.00916468615119124 0.485353525708887 no 1623 0.49634387038837 2419 563260 SGTC_2834 9001755 58.44 µM -0.0105217642390297 0.485913602087725 no 1624 0.495802500829901 2464 2989575 SGTC_897 1000-0139 31.4 µM -0.0111779381616658 0.486184420057113 no 1625 0.495540740721118 2418 6151020 SGTC_1698 5-fluorocytosine 1.055 µM -0.0141828640153517 0.487424701110235 no 1626 0.494342045574075 2431 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2791 5663188 71.43 µM -0.0153776592257669 0.487917886467653 no 1627 0.493865443337749 2443 54690634 SGTC_1671 st016596 74.5 µM -0.0164270991736134 0.488351087615533 no 1628 0.493446830324979 2450 2829167 SGTC_1912 st060209 90.8 µM -0.0175439894951509 0.488812146870314 no 1629 0.493001319847763 2444 688787 SGTC_141 0443-0274 32.331 µM -0.0178294811235367 0.488930002009778 no 1630 0.492887442979794 2434 1627241 SGTC_994 3910-0338 138 µM -0.0182144791122105 0.489088936365793 no 1631 0.49273387594587 2461 3479481 SGTC_1563 conessine 56.1 µM -0.0201851755254111 0.489902503220259 no 1632 0.4919478268473 2453 441082 An anti-amoebic, histamine inhibitor. SGTC_2555 cholic acid 100 µM -0.0216601711154791 0.490511456510179 no 1633 0.491359517579049 2540 6708657 Influences liver metabolism. SGTC_3303 9125618 40.5795 µM -0.0218156467124716 0.49057564606698 no 1634 0.491297506442899 2473 22695467 SGTC_2127 5253358 187.912 µM -0.0220314267375873 0.490664733275981 no 1635 0.491211443353012 2447 20612 SGTC_134 0269-0018 6.916 µM -0.0224700452220343 0.490845823278588 no 1636 0.49103650320738 2471 4378915 SGTC_493 zm226600 134 µM -0.0226073747719661 0.490902522164602 no 1637 0.490981730557448 2466 5240098 A potassium channel opener. YCR052W RSC6 SGTC_352 k048-0007 5.11 µM -0.0228631135389394 0.491008108838138 no 1638 0.490879731915356 2448 6811911 SGTC_1768 st044301 37.178 µM -0.023868782167052 0.491423324533326 no 1639 0.490478637703578 2460 3931349 SGTC_2648 atorvastatin 78.68 µM -0.0241011382176932 0.491519259935987 no 1640 0.490385967710431 2452 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_817 1391-0715 46 µM -0.0246591254926547 0.491749644282939 no 1641 0.490163429144679 2464 1353946 SGTC_72 0744-0168 198.391 µM -0.0247960395570541 0.491806174413678 no 1642 0.490108825032137 2491 677577 SGTC_1643 st009866 20.2 µM -0.0253914193582612 0.492052001299047 no 1643 0.489871377631566 2453 3156273 YOR207C RET1 SGTC_1315 1237-0019 3.69 µM -0.0256652611776357 0.492165069105828 no 1644 0.489762166144168 2451 825140 SGTC_2365 9042475 200 µM -0.0260851484464582 0.492338439508646 no 1645 0.489594711427909 2470 6464479 SGTC_439 amiodarone 34.4 µM -0.0261466650926599 0.492363839700294 no 1646 0.489570178204548 2504 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2702 st077768 96.8 µM -0.0261892159688366 0.492381408953353 no 1647 0.489553208672007 2484 6484119 SGTC_1032 k061-1018 98.7 µM -0.0263471673978071 0.492446627213578 no 1648 0.489490216905279 2573 4005393 SGTC_2565 isoliquiritigenin 100 µM -0.0266873882339356 0.492587105328529 no 1649 0.489354536141166 2527 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3048 9093155 49.47 µM -0.0290774019480599 0.493573973464334 no 1650 0.488401429404547 2454 25236002 SGTC_2681 menadione 3.18 µM -0.0297994071461291 0.49387210693021 no 1651 0.48811351579345 2479 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2345 9052315 157.45 µM -0.030278731534748 0.494070033501929 no 1652 0.487922379285689 2490 6469265 SGTC_2553 4-methylesculetin 85.09 µM -0.0302830318971202 0.494071809249635 no 1653 0.48792066447568 2452 5319502 SGTC_516 3992-2719 87.3 µM -0.0305628568318797 0.494187357550432 no 1654 0.487809082128238 2460 5350887 YDR037W KRS1 SGTC_513 4245-1575 41.7 µM -0.0318347950725198 0.494712585876174 no 1655 0.487301899117772 2544 719745 SGTC_317 4495-0002 170 µM -0.0323682530211445 0.494932872328114 no 1656 0.487089189817313 2500 15991618 SGTC_2064 5220758 200 µM -0.0330028238106579 0.495194914385151 no 1657 0.486836167897095 2512 788518 SGTC_916 4466-0038 42 nM -0.0346812994880827 0.495888040162888 no 1658 0.486166936401449 2466 5722064 YGL116W CDC20 SGTC_2837 9008476 45.46 µM -0.0350877199265728 0.496055873246831 no 1659 0.48600489673142 2527 2992805 SGTC_3337 9144342 33.5465 µM -0.0358415251273949 0.496367162201775 no 1660 0.485704361029981 2506 17682949 SGTC_671 0560-0003 407 µM -0.0365677387994942 0.496667059142554 no 1661 0.485414833512897 2528 3238678 SGTC_2626 ethyl orsellinate 100 µM -0.0365990740278483 0.496679999370961 no 1662 0.485402340927937 2489 75653 A natural product. SGTC_761 k216-0224 480 µM -0.036702317484778 0.496722634920678 no 1663 0.485361180402019 2469 1340404 SGTC_2295 7971645 200 µM -0.0368158438884552 0.496769516972398 no 1664 0.48531592050827 2508 2978226 YKL099C UTP11 SGTC_1705 st027868 56.3335 µM -0.037240672430144 0.496944955261314 no 1665 0.485146554590269 2541 292948 SGTC_2231 micatex 6.853 µM -0.0379228978854005 0.497226690064606 no 1666 0.484874578152985 2497 20737 An antifungal of unknown mechanism. SGTC_1718 roemerine 11.9335 µM -0.0386745304511718 0.497537089127248 no 1667 0.484574939984184 2476 235224 An aporphine alkaloid with mutagenic activity. SGTC_2741 miltefosine 3.04 µM -0.0388090759458832 0.49759265207074 no 1668 0.484521304364437 2491 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3280 9140961 49.47 µM -0.0392778228225985 0.49778622974807 no 1669 0.484334443896712 2479 4901226 SGTC_736 0958-0254 92.6 µM -0.0395883312050796 0.497914460207432 no 1670 0.48421066524833 2514 6812352 SGTC_2851 9015922 71.43 µM -0.039822886236136 0.498011324400657 no 1671 0.484117165061807 2500 2996893 SGTC_627 1391-0720 175 µM -0.0426866214427213 0.49919396888737 no 1672 0.482975672195763 2518 997839 SGTC_2581 avocatin a 64 µM -0.0427472201381424 0.499218994607962 no 1673 0.482951518860804 2511 6710728 A skin care supplement. SGTC_2994 9053520 71.4286 µM -0.0430156048354849 0.499329830700341 no 1674 0.482844547253694 2510 4647384 SGTC_1349 flufenamic acid 69 µM -0.0430180759586037 0.499330851211946 no 1675 0.482843562329899 2487 3371 A non-steroidal anti-inflammatory. SGTC_2514 salinomycin 42.74 µM -0.0436922846531807 0.499609282561748 no 1676 0.482574844650122 2527 23682228 A polyether potassium ionophore. SGTC_2953 9074162 66.49 µM -0.0439269321108505 0.499706186152065 no 1677 0.482481323648137 2493 16451992 SGTC_932 2857-0803 154 µM -0.0442474083128288 0.499838534915606 no 1678 0.482353596332612 2668 674898 SGTC_1130 3454-2858 15.9 µM -0.0450293681644515 0.499838534915606 no 1679 0.482041950139751 2563 715628 YIL048W NEO1 SGTC_2557 derrustone 83.84 µM -0.045364340423581 0.499700199638813 no 1680 0.481908451965178 2560 629853 An antioxidant. SGTC_2027 5150920 200 µM -0.0459858587285607 0.499443528024336 no 1681 0.481660760542806 2526 786715 SGTC_1303 1160-0052 261 µM -0.0467738101367254 0.499118124019069 no 1682 0.481346751331876 2490 3562476 SGTC_2091 4-phenylthiadiazole 200 µM -0.0473571807498938 0.49887720707447 no 1683 0.481114277758257 2509 270010 SGTC_330 1488-0319 80.1 µM -0.04747120688695 0.498830117280054 no 1684 0.481068839015406 2542 6846614 SGTC_751 0833-0568 350 µM -0.0483855678760549 0.498452510894594 no 1685 0.480704480499899 2531 6954252 SGTC_3255 9139072 49.47 µM -0.0483959765982599 0.498448212380872 no 1686 0.480700332879544 2549 17646060 SGTC_787 4152-0075 138 µM -0.0499093497533695 0.497823233394237 no 1687 0.480097313282514 2523 9566539 SGTC_83 0170-0301 39.027 µM -0.0508420756353991 0.497438047364292 no 1688 0.479725681352376 2493 3089716 SGTC_3114 9122766 49.47 µM -0.0522580796898699 0.496853287552238 no 1689 0.47916152760516 2556 17176985 SGTC_721 1187-1332 279 µM -0.0526893399378975 0.496675193541244 no 1690 0.478989716362885 2484 25730 SGTC_2266 7929956 200 µM -0.0537082317614813 0.496254432829485 no 1691 0.478583812136385 2488 2967153 SGTC_2775 cyproheptadine 69.59 µM -0.0549291502229838 0.495750248895577 no 1692 0.478097454205294 2503 2913 A selective serotonin reuptake inhibitor. SGTC_2601 securinine 100 µM -0.0552069887344589 0.495635515114502 no 1693 0.47798678061199 2527 442872 A GABA receptor antagonist. SGTC_3059 1327-0034 3 µM -0.0557126321848911 0.495426709915381 no 1694 0.477785368052678 2527 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1688 st021091 57.6 µM -0.0559366575702906 0.495334199146459 no 1695 0.477696134007217 2503 3656366 SGTC_291 SEC14.278 35.5 µM -0.0562146887090687 0.495219387175081 no 1696 0.477585389884396 2502 1068044 SGTC_3352 9151559 45.5865 µM -0.0564746286696902 0.495112046249461 no 1697 0.477481853324363 2532 17159339 SGTC_210 3551-0445 56.827 µM -0.0569949955707556 0.494897164373458 no 1698 0.477274590809437 2594 2865180 YOR207C RET1 SGTC_454 lyso-paf C-16 6.67 µM -0.0573578847831645 0.494747312681258 no 1699 0.477130055407106 2535 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_851 0394-0702 453 µM -0.0584113429747087 0.494312301289521 no 1700 0.476710489906421 2512 762646 SGTC_2164 5685496 200 µM -0.0591183098038094 0.494020372606448 no 1701 0.476428937516359 2512 759046 SGTC_2786 7743617 45.45 µM -0.0593664864865895 0.493917893454682 no 1702 0.476330102935082 2540 583674 SGTC_2978 9011784 42.97 µM -0.059473736408959 0.493873607060731 no 1703 0.476287391874126 2656 2994934 SGTC_1649 st011737 51.3 µM -0.0597022814590788 0.493779234880197 no 1704 0.476196377318468 2547 1761035 SGTC_539 4859-0462 2.54 µM -0.0599782138236931 0.493665295712513 no 1705 0.476086493147923 2526 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2443 5493264 126.67 µM -0.0599901741075332 0.493660357032769 no 1706 0.476081730261406 2561 5340055 SGTC_651 3253-0966 34.4 µM -0.0606409257709433 0.493391648000449 no 1707 0.475822589714556 2528 781462 SGTC_881 0833-0569 170 µM -0.0613960689217866 0.493079837296828 no 1708 0.47552189150081 2514 5418700 SGTC_1326 1431-2094 10.8 µM -0.0614148898510496 0.493072065886857 no 1709 0.475514397178867 2512 616278 SGTC_2362 9071156 126 µM -0.0615700688274304 0.493007990540937 no 1710 0.475452606659746 2561 653133 SGTC_841 0251-0215 91.2 µM -0.0621996652689418 0.492748024140647 no 1711 0.475201914526113 2573 3888614 SGTC_294 k038-0071 157 µM -0.0622939145028369 0.492709107991714 no 1712 0.475164387294985 2565 24152826 SGTC_1271 0832-2808 169 µM -0.0627845231346993 0.49250653348395 no 1713 0.474969045150919 2563 3663794 SGTC_3165 9101544 49.47 µM -0.0634925364310921 0.492214195034139 no 1714 0.474687151159657 2562 5002184 SGTC_1952 st077036 64.1 µM -0.0637341492558887 0.492114434129902 no 1715 0.474590956419207 2507 2937007 SGTC_987 1497-1013 404 µM -0.063913147428034 0.492040526866234 no 1716 0.474519691775002 2503 1676435 SGTC_1840 st055363 71 µM -0.06436386490349 0.491854429560048 no 1717 0.474340250985977 2568 676033 SGTC_3046 9092212 49.47 µM -0.0645741816748867 0.491767592207594 no 1718 0.474256520916426 2520 25236637 SGTC_3248 9135562 49.47 µM -0.064654626929548 0.491734377399106 no 1719 0.474224494827722 2538 17650701 SGTC_546 peri-Naphthalide 147 µM -0.0648195982380168 0.491666263052306 no 1720 0.474158818563208 2588 223824 A penicillin ester. SGTC_3221 9128209 49.47 µM -0.0656668764282932 0.491316437605512 no 1721 0.473821522125904 2564 16460723 SGTC_520 3584-0023 682 µM -0.0670655460985035 0.490738967586347 no 1722 0.473264761174087 2610 1340790 SGTC_893 0958-0369 48.9 µM -0.0681884179506109 0.490275380452445 no 1723 0.472817823324373 2672 6819948 SGTC_2961 9083290 32.55 µM -0.0686915795799776 0.490067650146094 no 1724 0.47261756044731 2519 17741490 SGTC_1711 st032263 62.8 µM -0.0689021648704013 0.489980710793833 no 1725 0.472533747649749 2564 3958979 SGTC_1841 st054148 70 µM -0.0689714587561081 0.489952103175278 no 1726 0.472506168997683 2584 675442 SGTC_2760 etidronate 98.04 µM -0.0693369666827302 0.489801205996943 no 1727 0.472360700685864 2561 3305 A chelator and antioxidant. SGTC_1664 st014217 9.02 µM -0.069680672900308 0.489659310820352 no 1728 0.47222391258797 2540 3982782 SGTC_2696 st077691 74.316 µM -0.0705737842465898 0.489290606190358 no 1729 0.471868487757118 2625 757133 SGTC_67 0335-0847 266 µM -0.0707553439495593 0.489215653707844 no 1730 0.471796236533213 2811 4552207 YOR254C SEC63 SGTC_1932 st074806 40.9 µM -0.0709645501251774 0.489129288527738 no 1731 0.47171298461661 2748 17251235 SGTC_716 1683-5115 658 µM -0.0734657329722003 0.488096782635084 no 1732 0.470717755745496 2518 723597 SGTC_1966 st070145 16.1 µM -0.0735178971349779 0.488075249726531 no 1733 0.470697001378845 2520 3748532 SGTC_1531 st059297 52.4 µM -0.0747239326671171 0.487577418665449 no 1734 0.470217182694705 2612 7566702 SGTC_540 1187-0821 17.3 µM -0.0747769534625739 0.48755553301673 no 1735 0.470196089470609 2545 847520 SGTC_1626 st003712 1.76 µM -0.074970261004596 0.487475740850872 no 1736 0.470119186781919 2636 24207035 SGTC_234 nsc-17383 10.7 µM -0.0751524269117055 0.487400548111692 no 1737 0.470046717540749 2557 408974 SGTC_1754 st042065 16.137 µM -0.0755368496374616 0.487241871167922 no 1738 0.469893789750805 2587 1126236 YIL048W NEO1 SGTC_3347 9188721 44.724 µM -0.0763518550966817 0.486905470671988 no 1739 0.469569585902756 2602 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0772205915943405 0.486546902493497 no 1740 0.469224030416262 2634 688751 SGTC_2138 5575593 77.673 µM -0.0773678456149371 0.486486124942994 no 1741 0.469165459785202 2544 762213 SGTC_726 3448-4391 34.2 µM -0.0774682561093879 0.486444681745852 no 1742 0.469125521658772 2646 1356692 SGTC_3330 9141424 71.43 µM -0.0780846652626056 0.486190269670649 no 1743 0.468880352647423 2593 27261020 SGTC_3222 9128301 49.47 µM -0.078800595310798 0.485894789152145 no 1744 0.468595615266052 2572 4911358 SGTC_966 1300-0360 30.2 µM -0.0788625825177727 0.485869205992213 no 1745 0.468570962668272 2569 70588 SGTC_191 3914-0123 66.505 µM -0.0809110228326228 0.485023813668465 no 1746 0.467756356878258 2543 3144412 SGTC_378 3970-0959 8.33 µM -0.0811824716903558 0.484911791559917 no 1747 0.467648419532334 2634 6615653 SGTC_3054 9094397 49.47 µM -0.0815167561166563 0.484773839968544 no 1748 0.467515499885212 2578 2598354 SGTC_2816 7982706 58.44 µM -0.0818834177742402 0.48462252912539 no 1749 0.467369710426398 2633 2981853 SGTC_2852 9023854 51.95 µM -0.0827170512381049 0.484278520566646 no 1750 0.467038263204258 2641 19798528 SGTC_484 loperamide 105 µM -0.0828660637052085 0.484217030061855 no 1751 0.466979019221433 2532 3955 An opioid-receptor agonist. SGTC_860 0443-0016 25.1 µM -0.0830470954086398 0.484142327214689 no 1752 0.466907046099603 2563 5337942 SGTC_385 1494-0393 12.4 µM -0.0830628396740353 0.484135830359866 no 1753 0.466900786672899 2587 3090647 SGTC_3262 9137218 49.47 µM -0.083274155120897 0.484048631667698 no 1754 0.466816775063926 2520 17650664 SGTC_1679 SEC14.276 6.7 µM -0.0834183904204258 0.483989113837109 no 1755 0.466759433017115 2669 1005053 YMR079W SEC14 SGTC_2442 5158906 48.48 µM -0.0840004097542278 0.483748950690312 no 1756 0.46652805299233 2662 1893835 SGTC_3087 9117406 49.47 µM -0.0858585049713916 0.482982270347636 no 1757 0.465789448944507 2652 42546093 SGTC_2423 st077119 87.2 µM -0.085992251587545 0.482927086709755 no 1758 0.465736288373961 2514 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1164 k060-0068 93.7 µM -0.0874923263849593 0.482308180922292 no 1759 0.465140092350042 2561 5963676 SGTC_2937 9044753 11.33 µM -0.0880272324173949 0.482087497868611 no 1760 0.464927515906777 2570 6465530 YGL099W LSG1 SGTC_933 2914-0560 114 µM -0.0890770406464624 0.481654400645767 no 1761 0.464510341878691 2570 463887 SGTC_1941 st076221 61.8 µM -0.0892696501673223 0.481574942136607 no 1762 0.464433806702551 2710 2828568 SGTC_2013 4024628 200 µM -0.0904875649900486 0.481072524568922 no 1763 0.46394988755745 2672 5230760 SGTC_3164 9100705 49.47 µM -0.0906837863647732 0.480991581579573 no 1764 0.463871927074643 2682 17174235 SGTC_33 0986-0033 35.816 µM -0.0908965782600517 0.480903803995123 no 1765 0.463787384545859 2572 2848082 SGTC_536 3852-0578 10.6 µM -0.0913932027707607 0.480698947828806 no 1766 0.463590081275201 2707 2869208 SGTC_2985 9022375 71.43 µM -0.091625868204887 0.48060297576397 no 1767 0.463497649021511 2761 4939335 SGTC_129 0088-0017 176.636 µM -0.0923136541511709 0.480319277830261 no 1768 0.46322442012471 2561 182446 SGTC_2166 5933061 31.504 µM -0.0923240115741019 0.48031500567648 no 1769 0.463220305681419 2940 2877375 SGTC_264 promethazine 12.5 mM -0.0933039379420385 0.479910823137253 no 1770 0.462831051853693 2558 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1369 1866-0067 208 µM -0.0936089984856229 0.479785001405075 no 1771 0.462709880623879 2565 3531355 SGTC_1510 1123-0200 71.5 µM -0.0939935144743267 0.479626411272913 no 1772 0.462557154314183 2729 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1437 4092-1038 11.6 µM -0.0940462086055579 0.479604678307105 no 1773 0.462536225106357 2576 3977136 SGTC_3113 9123498 49.47 µM -0.0951960644574054 0.479130451369105 no 1774 0.462079547950125 2557 8897275 SGTC_1007 4101-0031 70 µM -0.0962478501523372 0.478696696666987 no 1775 0.461661864130019 2576 1146276 SGTC_1291 0993-0025 5.79 µM -0.0967074937926562 0.478507148272614 no 1776 0.461479344271342 2657 4353356 SGTC_2517 totarol 10 µM -0.0973054672098945 0.478260562561562 no 1777 0.461241907200476 2628 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2090 5301565 104.445 µM -0.0980869957208315 0.477938296976608 no 1778 0.460931606820409 2602 2056344 SGTC_1435 4092-0789 56.7 µM -0.0994781538886274 0.477364684632837 no 1779 0.460379316261936 2581 2248285 SGTC_1908 st060353 56.5 µM -0.0996923569338849 0.4772763670285 no 1780 0.460294284298336 2670 4227716 SGTC_2699 st077704 54.6 µM -0.100412011210522 0.476979656094959 no 1781 0.460008617197145 2634 645852 SGTC_3309 9129340 25.759 µM -0.100891242854922 0.476782077637747 no 1782 0.459818397412898 2651 17158987 SGTC_2584 androsterone 48.74 µM -0.102670503605008 0.476048571232551 no 1783 0.459112242306184 2610 2754130 A steroid. SGTC_2025 5147754 141 µM -0.105479153526955 0.474890861715269 no 1784 0.457997805389645 2669 315777 YLR208W SEC13 SGTC_2802 7925815 54.55 µM -0.105791434447425 0.47476215421264 no 1785 0.457873916486215 2619 1262923 SGTC_1836 st055642 81 µM -0.105850729765464 0.47473771576951 no 1786 0.457850393154559 2602 8571 SGTC_1087 pterostilbene 9.05 µM -0.107150761433595 0.47420193444474 no 1787 0.457334688567406 2692 5281727 Similar to reservatol, lowers cholesterol. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.107191522975503 0.474185136162594 no 1788 0.457318520184279 2808 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_507 nimesulide 162 µM -0.107806460568629 0.473931719166932 no 1789 0.457074608984756 2762 4495 A COX2 inhibitor. SGTC_1725 st036284 20.55 µM -0.107875290108115 0.473903355032405 no 1790 0.457047309177411 2797 707914 SGTC_2083 5306046 65.942 µM -0.107879579137723 0.473901587560002 no 1791 0.457045608029602 2630 539837 SGTC_3213 9129884 49.47 µM -0.108254014523598 0.473747287925313 no 1792 0.456897099633148 2673 17190742 SGTC_1907 st060210 83.7 µM -0.109462142802046 0.473249461971868 no 1793 0.456417973480381 2689 688793 SGTC_262 fenpropimorph 62.5 µM -0.111076499242091 0.472584309435276 no 1794 0.455777842146142 2601 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2314 7727897 200 µM -0.111142256673393 0.472557217446402 no 1795 0.455751770157447 2622 900724 SGTC_629 3448-6466 76.7 µM -0.11170889248836 0.472323769391842 no 1796 0.455527114140239 2621 573744 SGTC_3103 9120822 49.47 µM -0.112510084688868 0.471993702792691 no 1797 0.455209487044222 2786 17141819 SGTC_3331 9141060 1.957 µM -0.112742043926156 0.471898146285611 no 1798 0.455117533747457 2615 4906567 YPR165W RHO1 SGTC_766 1391-0721 126 µM -0.112935453743893 0.471818471597816 no 1799 0.455040864052474 2757 1020919 YIL115C NUP159 SGTC_826 1683-5028 118 µM -0.112970827412417 0.47180389962597 no 1800 0.455026841737644 2676 722377 SGTC_1047 2043-3044 82 µM -0.113530893569617 0.471573188754186 no 1801 0.454804835941608 2614 669592 SGTC_1856 st057054 55.7 µM -0.113908718702959 0.471417554728196 no 1802 0.45465507701547 2810 1266018 SGTC_2771 fluoxetine 41.05 µM -0.115451517005062 0.470782089591847 no 1803 0.454043623625352 2728 3386 A selective serotonin reuptake inhibitor. SGTC_1731 st035964 63 µM -0.116339076395607 0.470416545241166 no 1804 0.453691908687256 2680 6739575 SGTC_1140 3229-1848 2.98 µM -0.116879978696262 0.470193784995871 no 1805 0.453477582040913 2692 2849525 SGTC_1203 3992-3522 103 µM -0.117703120205846 0.469854807862842 no 1806 0.453151447201179 2855 5322312 SGTC_2436 5633522 8.09 µM -0.118130715402951 0.469678728891875 no 1807 0.452982043233076 2639 5724242 SGTC_1370 2001-0092 44.6 µM -0.118612957087249 0.46948015421824 no 1808 0.452790999777262 2684 790957 SGTC_1462 k081-0014 26.5 µM -0.118697607860273 0.469445297997464 no 1809 0.452757465900683 2624 3270634 SGTC_688 0527-0193 473 µM -0.118819703298172 0.469395023788879 no 1810 0.452709099146831 2668 4007154 SGTC_3 0833-0587 95.581 µM -0.119497318087479 0.469116016953332 no 1811 0.452440682334637 2598 5382644 SGTC_780 0109-0199 192 µM -0.120150454736982 0.468847103305891 no 1812 0.452181982373504 2799 610414 SGTC_1364 1653-0028 37.6 µM -0.120646782426767 0.468642761554769 no 1813 0.451985406217916 2694 5718652 SGTC_645 0845-0943 5.41 µM -0.120741812635514 0.468603637861223 no 1814 0.451947769777632 2664 1885106 SGTC_453 enantio-paf c16 10 µM -0.121244033664106 0.468396879794348 no 1815 0.451748873766403 2657 13871343 A lipid and platelet activating factor SGTC_2820 7989630 71.43 µM -0.123376200450432 0.467519189185055 no 1816 0.450904601181752 2637 2984098 SGTC_739 1486-1183 203 µM -0.123774553992924 0.467355227286761 no 1817 0.450746889915563 2624 4346692 SGTC_876 0720-0963 56.8 µM -0.125195568623954 0.466770384474148 no 1818 0.450184362684855 2808 765861 SGTC_2734 clemastine 41.6 µM -0.126452384194068 0.46625318032788 no 1819 0.449686919155629 2617 26987 Clemastine is a selective histamine H1 antagonist. SGTC_236 1509-0011 5.31 µM -0.127533218599329 0.465808441409965 no 1820 0.449259191594972 2698 3107280 SGTC_1212 0520-0165 585 µM -0.129029262823971 0.465192923608179 no 1821 0.448667246990642 2997 5403258 SGTC_1159 4092-0538 61.2 µM -0.129223515347187 0.465113008326874 no 1822 0.448590394826379 2645 717301 SGTC_2455 5377712 9.75 µM -0.129701751348495 0.464916268547824 no 1823 0.448401198449273 2699 2243908 SGTC_2235 salicylic acid 500 µM -0.129795289571287 0.464877789197883 no 1824 0.448364194883516 2636 338 A COX inhibitor and kinase inhibitor. SGTC_1377 2944-0135 198 µM -0.129964388409798 0.464808226882156 no 1825 0.448297300803942 2719 1894137 SGTC_2468 5987765 72.9 µM -0.130758178302889 0.464481699349137 no 1826 0.447983303871413 2707 26772094 SGTC_666 0272-0154 136 µM -0.131543773547285 0.464158566255143 no 1827 0.447672580555785 2670 6870312 SGTC_2982 9019404 25.97 µM -0.133076721008398 0.463528098552734 no 1828 0.447066352662944 2678 22333232 SGTC_2871 9038510 12.99 µM -0.134014268841419 0.463142550706847 no 1829 0.446695645656836 2654 4945164 SGTC_306 1672-3436 11.6 µM -0.134294507685623 0.463027314775732 no 1830 0.446584848067386 2732 6797378 SGTC_1204 4049-0315 18.3 µM -0.134867119282261 0.462791863032822 no 1831 0.446358468498061 2908 588402 SGTC_2496 diffractaic acid 79.83 µM -0.135292805411471 0.462616833908064 no 1832 0.446190186614768 2867 94870 An apoptosis inducer which activates caspases. SGTC_2666 tannic acid 100 µM -0.135582476674612 0.462497734075088 no 1833 0.4460756795536 2681 16134267 A thiamine antagonist. SGTC_310 1273-0058 1.06 µM -0.136241255914808 0.462226886129299 no 1834 0.445815280853702 2695 2734232 SGTC_486 niguldipine 82 µM -0.137367269726947 0.461763981791049 no 1835 0.44537025036802 2625 1236 A calcium channel blocker. SGTC_1060 3448-7350 82 µM -0.137688789241618 0.461631814579621 no 1836 0.445243189947713 2731 570178 SGTC_768 0384-0033 77.3 µM -0.137871790512166 0.46155659003354 no 1837 0.445170872685631 2656 3965305 YMR134W ERG29 SGTC_2310 7668677 200 µM -0.137999215347624 0.461504211562251 no 1838 0.445120518838219 2799 2197143 SGTC_1989 st071868 50.2 µM -0.138551939465322 0.461277019918105 no 1839 0.444902111819425 2771 16414057 SGTC_16 erodoxin 22.806 µM -0.138702542970429 0.461215118062043 no 1840 0.444842604263237 2652 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2850 9015429 58.44 µM -0.1387739160714 0.461185782237444 no 1841 0.444814403236689 2703 6457570 SGTC_593 1203-0218 61.7 µM -0.139082295102938 0.461059034490214 no 1842 0.444692559350746 2769 3666956 SGTC_252 miconazole 1.30953 nM -0.139580057658367 0.460854456030554 no 1843 0.444495899019185 2700 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1980 st071811 45.7 µM -0.140791717488338 0.460356511998529 no 1844 0.444017243187857 2808 4974850 SGTC_1518 st038567 90.8 µM -0.142482124295444 0.459661926014135 no 1845 0.443349599029417 2634 77966 SGTC_2347 9049783 174.81 µM -0.142637163384405 0.45959822678253 no 1846 0.44328837271252 2775 6467988 YPL169C MEX67 SGTC_491 tetrandrine 80.3 µM -0.142918810233055 0.459482512246111 no 1847 0.443177151328775 2751 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2177 5811945 192 µM -0.143809639452247 0.459116537929728 no 1848 0.442825395410937 2804 5343475 SGTC_354 2783-3500 4.88 µM -0.14390282258183 0.459078258029226 no 1849 0.442788603395453 2690 6740761 SGTC_1502 4534-4282 27.7 µM -0.143974194185281 0.459048938623644 no 1850 0.442760423680281 2681 3278949 SGTC_1481 3346-2004 36 µM -0.144300284510046 0.458914983778811 no 1851 0.442631676826397 2671 2770522 SGTC_1228 0124-0032 52.5 µM -0.145436131942443 0.458448424836006 no 1852 0.442183269377566 2730 X1228 SGTC_665 3914-0008 307 µM -0.145467828894887 0.458435405862567 no 1853 0.442170757181345 2667 1069549 SGTC_2805 7950783 58.44 µM -0.145838067499726 0.458283340083046 no 1854 0.442024611820843 2781 1178958 YDL195W SEC31 SGTC_2855 9016525 58.44 µM -0.145955314001109 0.458235185434872 no 1855 0.441978332412776 2651 43811474 SGTC_2950 9072895 21.46 µM -0.146902816425918 0.45784605653936 no 1856 0.441604364428302 2748 17332245 SGTC_1920 st075728 45.7 µM -0.14704285211171 0.457788548830875 no 1857 0.441549098408606 2788 3400306 SGTC_1125 tnp00248 1.32998 µM -0.147771516488098 0.457489326405905 no 1858 0.44126154453098 2830 24207736 SGTC_2199 6590217 200 µM -0.148219414273947 0.457305411340483 no 1859 0.441084805334538 2706 703109 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.148244975727908 0.457294915612959 no 1860 0.441074719210848 2689 641818 YHR062C RPP1 SGTC_1493 4348-0038 111 µM -0.148778846099997 0.457075711193936 no 1861 0.440864071605186 2674 800424 SGTC_1956 st077085 54 µM -0.148838652995551 0.457051155603546 no 1862 0.440840474821712 2711 24208685 SGTC_1070 indatraline 8.81 µM -0.151333959088173 0.456026776965017 no 1863 0.43985614114035 2702 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_297 0986-0032 24 µM -0.151722776069214 0.455867185090692 no 1864 0.43970279621705 2659 2847425 SGTC_3238 9133470 49.47 µM -0.152074481069371 0.455722832147152 no 1865 0.439564095621437 2805 3534688 SGTC_944 3370-0224 231 µM -0.152915359465759 0.455377727794339 no 1866 0.439232511630747 2715 4580514 SGTC_2979 9012552 45.46 µM -0.153517560525172 0.45513059952639 no 1867 0.438995071577195 2755 17100905 SGTC_567 1080-0542 68.4 µM -0.154482016993861 0.454734846900939 no 1868 0.438614844684999 2673 5950415 SGTC_2121 5257820 149.641 µM -0.154988723499197 0.454526944213213 no 1869 0.438415103612558 2795 791256 SGTC_1756 st041558 35.5 µM -0.155790397246473 0.454198041345881 no 1870 0.438099120045542 2803 3955792 SGTC_1100 amiodarone 5.07 µM -0.155797700604039 0.454195045139754 no 1871 0.438096241573084 2772 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_71 0417-1750 47.813 µM -0.157272328187754 0.453590132056575 no 1872 0.437515113874153 2849 6811472 SGTC_1640 st009078 66.4 µM -0.160437169558265 0.452292234637083 no 1873 0.436268355878272 2820 690618 SGTC_1477 0139-0234 16 µM -0.160522385359113 0.452257294729582 no 1874 0.436234794650691 2673 620880 SGTC_2135 5326629 150.42 µM -0.160590337297188 0.452229433560304 no 1875 0.4362080329187 2741 5020077 SGTC_605 1315-0399 119 µM -0.160723663273076 0.452174768877733 no 1876 0.43615552556626 2798 24020461 SGTC_2246 7293507 91.5585 µM -0.162368610087265 0.451500402860496 no 1877 0.435507794162059 2885 887656 SGTC_2698 st077697 67.5 µM -0.162737189836691 0.451349318216632 no 1878 0.435362682019102 2735 3154499 SGTC_1988 st071872 53.4 µM -0.163724269684842 0.450944738765327 no 1879 0.434974105454559 2699 16414116 SGTC_2051 5263410 176 µM -0.164189037554092 0.45075425960885 no 1880 0.434791165379424 2687 227584 SGTC_1168 k815-0004 80.5 µM -0.164827438298444 0.4504926377397 no 1881 0.434539903388778 2690 642433 SGTC_1220 1838-0075 193 µM -0.165722460545149 0.450125886514027 no 1882 0.434187684753935 2723 5529645 SGTC_2640 pentamidine 10.38 µM -0.165731599259236 0.45012214198311 no 1883 0.43418408865932 2791 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_57 miconazole 162.5 nM -0.165871599359274 0.450064778373362 no 1884 0.434128999138242 2660 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2718 lomofungin 53.02 µM -0.16641605651257 0.449841702549946 no 1885 0.433914769435153 2829 5351222 A RNA synthesis inhibitor. SGTC_3160 9100216 49.47 µM -0.166740791913142 0.449708659002449 no 1886 0.433787003753341 2663 17191039 SGTC_760 0568-0725 82.9 µM -0.167165180950085 0.449534796051099 no 1887 0.433620040226874 2862 3916171 SGTC_2296 7971656 126.45 µM -0.167221708407774 0.449511638712439 no 1888 0.433597802035576 2770 666570 SGTC_1645 Cervolide 78 µM -0.167571561851997 0.449368319720031 no 1889 0.433460172578371 2780 23173 A fragrance. SGTC_2316 5844804 197.44 µM -0.167769057680345 0.449287417606374 no 1890 0.433382482911528 2819 776813 SGTC_1409 3909-8004 61.9 µM -0.16818813097867 0.449115755571797 no 1891 0.433217639022891 2740 2119279 SGTC_3263 9137018 49.47 µM -0.168294745890082 0.449072085177277 no 1892 0.433175703542357 2730 43844957 SGTC_222 nsc-310342 10.666 µM -0.168951558692308 0.448803062571521 no 1893 0.432917372049728 2700 432556 SGTC_1393 3470-5649 58.2 µM -0.169841903743108 0.448438425573421 no 1894 0.432567235614466 2791 4108395 SGTC_2692 st077426 47.7 µM -0.175855241480604 0.445976844650051 no 1895 0.430203834695694 2833 25238571 SGTC_2840 9008771 71.43 µM -0.175941459759049 0.44594156579997 no 1896 0.430169966596191 2881 2992978 SGTC_834 0312-0008 75.7 µM -0.176099449516725 0.445876920561151 no 1897 0.430107906694703 2701 6385573 YIL048W NEO1 SGTC_2070 5230947 200 µM -0.176206919486242 0.445832947508323 no 1898 0.430065692440162 2785 2835538 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.176256333528016 0.445812729188246 no 1899 0.430046282849579 2702 4620898 SGTC_1422 4031-0024 15.5 µM -0.177158533757267 0.445443608475828 no 1900 0.42969193283923 2712 782427 SGTC_2516 gossypol 71.55 µM -0.177384638338529 0.445351108821407 no 1901 0.429603136404628 2860 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1208 2323-2347 50.3 µM -0.177812662402945 0.445176011815743 no 1902 0.42943505133159 2841 5412760 SGTC_886 0866-0150 153 µM -0.178127163786726 0.445047361727066 no 1903 0.42931155477252 2908 271463 SGTC_1634 st006576 41 µM -0.178409280021123 0.444931964047226 no 1904 0.429200780909979 2857 3915356 SGTC_1033 k072-0102 21.3 µM -0.179916507975847 0.444315522258273 no 1905 0.428609057593399 2856 5965931 SGTC_326 k292-0812 17.5 µM -0.18193721047497 0.443489285870545 no 1906 0.427816001036066 2728 3579357 SGTC_1384 3089-0840 101 µM -0.182169589036816 0.443394285275149 no 1907 0.427724819035228 2807 1069836 SGTC_1457 k015-0032 57.3 µM -0.18318992079816 0.442977193613848 no 1908 0.427324501292717 2711 4302660 SGTC_1306 1185-0270 9.02 µM -0.183825231224964 0.442717523029021 no 1909 0.427075280885155 2830 1548076 SGTC_1434 4073-0095 163 µM -0.183931584539738 0.442674055614097 no 1910 0.427033563308538 2751 24133745 SGTC_2415 st077333 57.7 µM -0.184394550854092 0.442484845779362 no 1911 0.426851972157598 2940 2766255 SGTC_1629 st005085 44.9 µM -0.184510675996822 0.442437388617962 no 1912 0.42680642635322 2737 24207091 SGTC_455 paf C-16 10 µM -0.1849116342675 0.442273534322025 no 1913 0.426649172765037 2719 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3327 9140648 26.9345 µM -0.185380723824043 0.442081850254357 no 1914 0.426465213268389 2849 8029710 SGTC_2054 5233173 129 µM -0.186185294741683 0.441753110037008 no 1915 0.42614972771504 2883 6889 SGTC_2817 7995342 71.43 µM -0.186972727705627 0.441431411070606 no 1916 0.42584100799201 2721 18879975 SGTC_2221 6807166 181.081 µM -0.18708892086409 0.441383944620863 no 1917 0.425795457329555 2758 674925 SGTC_2430 5571206 200 µM -0.187547786107235 0.441196500303358 no 1918 0.425615580208928 2872 1731771 SGTC_2486 5283202 22.39 µM -0.187587570177706 0.441180249315516 no 1919 0.425599985413338 2800 1377751 SGTC_1749 st037932 54.2 µM -0.187774971503441 0.441103700998058 no 1920 0.425526528297364 2871 594497 SGTC_1845 st056753 3.01 µM -0.189534386097552 0.440385135927803 no 1921 0.424837003635593 2687 5375839 SGTC_3157 9099274 49.47 µM -0.189694916881705 0.440319583052944 no 1922 0.424774102115296 2796 17217662 SGTC_988 1497-1057 103 µM -0.190796754513509 0.439869691006417 no 1923 0.42434241574999 2744 3533044 SGTC_1872 amphotericin b 148 nM -0.191541668764387 0.439565578528322 no 1924 0.424050618934399 2875 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.191681126792845 0.439508648514524 no 1925 0.423995995243557 2883 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.191900130811893 0.4394192485008 no 1926 0.423910217487138 2701 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.191961458173794 0.439394214504646 no 1927 0.423886197918559 2714 1241132 A phosphatase inhibitor. SGTC_732 3970-1727 52.7 µM -0.192707282474183 0.439089786420303 no 1928 0.42359410988557 2865 1275699 SGTC_469 w7 172 µM -0.193299148795428 0.438848226020365 no 1929 0.423362346460285 2757 45115570 A P450 inhibitor. SGTC_588 3970-1144 52.9 µM -0.194330852523688 0.438427207797499 no 1930 0.422958414634092 2896 1888707 SGTC_1269 0831-0796 3.05 µM -0.19444504904497 0.43838061069257 no 1931 0.422913709472639 2858 927758 SGTC_617 3770-0098 35 µM -0.195376138313537 0.438000718053777 no 1932 0.42254924775475 2763 5962639 SGTC_1631 benzylvanillin 81.9 µM -0.195766164465875 0.437841600899873 no 1933 0.422396597220773 2900 75506 SGTC_331 k048-0133 24.5 µM -0.197661302154156 0.437068593919067 no 1934 0.421655034347417 2754 6813582 SGTC_3129 9127257 49.47 µM -0.198092016457941 0.436892943420263 no 1935 0.421486535505768 2790 837894 SGTC_1810 st050138 53 µM -0.198125342986577 0.436879352977178 no 1936 0.421473498503041 2780 3444541 SGTC_2998 9066762 71.4286 µM -0.198210267643662 0.436844721332633 no 1937 0.421440277220758 2903 4945196 SGTC_3038 9091290 49.47 µM -0.200026399647311 0.436104232459631 no 1938 0.420729967198947 2898 25236843 SGTC_2928 9011484 9.79 µM -0.200154112200089 0.43605216880152 no 1939 0.420680027039978 2879 2994751 SGTC_404 fumagillin 50 µM -0.200565464345044 0.435884483366987 no 1940 0.420519182374963 2798 12015870 A methionine aminopeptidase binder. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.204140782560267 0.434427513212819 no 1941 0.419121742717589 2922 23847180 SGTC_2034 5197015 53.07 µM -0.204360531780001 0.434337992522452 no 1942 0.419035885188393 2910 780676 SGTC_1743 st037606 46.3785 µM -0.20498099098806 0.434085250147588 no 1943 0.418793488339816 2781 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1787 fluconazole 80 µM -0.205028838362943 0.434065760766943 no 1944 0.418774796926934 2804 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1287 0971-0001 34.6 µM -0.205952561649842 0.43368953764022 no 1945 0.418413983582717 2772 4665869 SGTC_2521 angolensin 13.4 µM -0.205994767161625 0.433672349195768 no 1946 0.418397499426093 2914 821428 A flavenoid. SGTC_1703 st026983 48.3 µM -0.206001611457945 0.433669561827405 no 1947 0.41839482627091 2911 1104023 SGTC_2679 rapamycin 1 nM -0.207908440419743 0.4328931267143 no 1948 0.417650229338006 2850 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1088 bifonazole 369 nM -0.207975541903235 0.432865808592546 no 1949 0.417624032265105 2756 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2437 5741531 144.16 µM -0.208815870492389 0.432523724160237 no 1950 0.41729599079082 2952 2262990 SGTC_1847 st056231 15 µM -0.210717263631422 0.431749884242979 no 1951 0.416553951314753 2782 5393180 SGTC_2180 6301957 200 µM -0.211493058567225 0.431434221797014 no 1952 0.416251274089177 2850 845462 SGTC_2080 5212524 12.4 µM -0.211905224113804 0.431266533956259 no 1953 0.416090487447757 2789 260183 SGTC_101 0490-5701 117.494 µM -0.212064481700856 0.431201743984825 no 1954 0.416028364489887 2744 4661669 SGTC_867 0518-0118 155 µM -0.212100297731439 0.431187173382292 no 1955 0.416014393715952 2794 6848158 SGTC_1624 st003710 6.25 µM -0.21326381036431 0.430713886656951 no 1956 0.415560599682082 2974 24207033 SGTC_2952 9073731 13.78 µM -0.213563509581069 0.430591992886064 no 1957 0.415443728989853 2801 16457353 SGTC_3035 9091303 49.47 µM -0.216851038318127 0.429255324636799 no 1958 0.414162217681977 2789 25237002 SGTC_3242 9133940 49.47 µM -0.217766637354062 0.428883197160186 no 1959 0.413805470126847 2935 17248444 SGTC_1684 st024538 14.6195 µM -0.217850086571224 0.428849283981757 no 1960 0.41377295909431 2794 6732859 SGTC_420 mitomycin C 81.9 mM -0.217895952804559 0.428830644488881 no 1961 0.413755090291554 2799 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2036 5160441 105 µM -0.218028763061066 0.428776672872221 no 1962 0.413703350397031 2844 134534 YIL048W NEO1 SGTC_778 3456-2434 196 µM -0.219448351684298 0.428199861872159 no 1963 0.413150404304297 2963 5539063 SGTC_3349 9149703 23.001 µM -0.220161341774518 0.427910215637893 no 1964 0.41287275137362 2756 4910494 SGTC_337 1315-0038 354 µM -0.220454076949546 0.427791305670779 no 1965 0.412758766918465 2806 1626437 SGTC_3110 9122132 49.47 µM -0.220962092308018 0.427584963774165 no 1966 0.412560974694147 2949 918317 SGTC_972 1319-0219 195 µM -0.221012841317485 0.427564352006434 no 1967 0.41254121714139 2872 23903702 SGTC_180 1486-1293 102.781 µM -0.221131118029482 0.427516314553167 no 1968 0.412495170632328 2873 4140536 SGTC_2048 5246248 200 µM -0.22114977572059 0.427508736929931 no 1969 0.412487907084645 2878 677046 SGTC_1923 st058458 19.1 µM -0.22144876573815 0.427387308957182 no 1970 0.412371512621534 3043 3534982 SGTC_2377 9073351 62.6 µM -0.222515138899978 0.426954281926341 no 1971 0.411956444759581 2780 7337946 YHR072W ERG7 SGTC_368 fentichlor 4.58 µM -0.222658443806217 0.426896096144178 no 1972 0.411900673225466 2879 7329 A pesticide. SGTC_2208 7283366 200 µM -0.22384221051314 0.426415514852807 no 1973 0.411440041983013 2886 898663 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.226136125399402 0.425484551202154 no 1974 0.410547774113154 2874 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_836 0330-0104 1.35 µM -0.226393899839859 0.425379961744505 no 1975 0.410447536001021 2804 46494820 SGTC_2549 cedrol 20.94 µM -0.227905953878858 0.42476656657941 no 1976 0.409859676998219 2983 6708665 A sedative which affects the nervous system. SGTC_2630 antimycin a 100 µM -0.22797992745105 0.424736562371487 no 1977 0.409830922610516 2740 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1217 1183-1422 255 µM -0.229160652598856 0.424257710980533 no 1978 0.409372026757874 2944 2849664 SGTC_2568 diosmetin 100 µM -0.229243466487902 0.424224129412235 no 1979 0.409339845299368 2927 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3180 9109287 49.47 µM -0.229248212108408 0.424222205049053 no 1980 0.409338001170822 2932 18891271 SGTC_561 1550-0330 72.9 µM -0.229952253103366 0.423936734378078 no 1981 0.409064435994052 2810 6812934 SGTC_2393 9031399 185.94 µM -0.23006139146836 0.423892485123085 no 1982 0.409022032686054 2969 1526623 YDL150W RPC53 SGTC_1249 0481-0015 10.2 µM -0.230164639215055 0.423850625054229 no 1983 0.408981919028076 2787 4227577 SGTC_1057 3448-5381 134 µM -0.232030215928744 0.423094406713152 no 1984 0.408257272612565 2948 5497911 SGTC_662 k832-1615 104 µM -0.232435260970949 0.422930257554914 no 1985 0.408099982222656 2901 5878478 SGTC_1867 st057372 64 µM -0.234687183363343 0.422017884869177 no 1986 0.407225768069791 2823 688837 SGTC_885 0865-0106 16.8 µM -0.236409368667377 0.421320418695599 no 1987 0.40655751353312 2819 2793380 SGTC_1489 4065-0444 182 µM -0.237321789433373 0.420950998163402 no 1988 0.406203579682617 2927 2877968 SGTC_3249 9135183 49.47 µM -0.23937691118299 0.420119176721358 no 1989 0.405406665924224 2996 4902779 SGTC_2020 4017018 200 µM -0.239617411452703 0.420021856201771 no 1990 0.405313432784923 2928 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_623 k072-0108 16.9 µM -0.239740507570096 0.419972046182132 no 1991 0.405265715010552 2909 5382803 SGTC_3225 9130819 49.47 µM -0.242642892435178 0.418797988701611 no 1992 0.404141025300361 2965 4547121 SGTC_989 1501-0895 10.3 µM -0.243430913520826 0.418479346888775 no 1993 0.403835799197665 2899 2830112 SGTC_3094 9117742 49.47 µM -0.243885892600023 0.418295397272205 no 1994 0.403659597704435 2808 17149698 SGTC_2933 9026794 32.47 µM -0.245794666841331 0.417523868423385 no 1995 0.402920592842981 2896 17586027 SGTC_2757 clomiphene 4.22 µM -0.245939499811903 0.417465339680524 no 1996 0.40286453313672 3057 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.246406405604723 0.417276669897433 no 1997 0.402683824063866 2929 140250 A respiratory chain inhibitor. SGTC_2847 9005661 71.43 µM -0.248207885918075 0.416548897004272 no 1998 0.401986782577806 2917 2991449 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.248447488185943 0.416452122525727 no 1999 0.401894097408311 3012 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1251 0490-5699 265 µM -0.251371214906186 0.415271649627822 no 2000 0.400763560265434 3008 3883818 SGTC_1314 1222-0010 41.1 µM -0.251869213167245 0.415070655622861 no 2001 0.400571078451493 2894 3526027 SGTC_1830 st055982 50.3 µM -0.252626924876103 0.414764882929006 no 2002 0.400278260853649 2884 455313 An antimicrobial agent. SGTC_1460 k062-0059 9.15 µM -0.255409217140026 0.413642540004893 no 2003 0.399203526285037 2758 1373085 SGTC_2669 eugenol 100 µM -0.255688049291462 0.413530101223642 no 2004 0.399095861893314 2929 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1635 st007035 42.4 µM -0.25573028567548 0.413513070062897 no 2005 0.399079553989161 2883 3716403 SGTC_1992 st073643 23.3 µM -0.255807776471341 0.413481823535548 no 2006 0.399049634450492 2828 3161292 SGTC_381 3461-2219 42.7 µM -0.256320891733413 0.413274934474482 no 2007 0.398851533354288 2978 2883159 SGTC_1320 1313-0481 95.3 µM -0.25686655258188 0.413054949390098 no 2008 0.398640895798333 3015 6813365 YLR208W SEC13 SGTC_831 k061-1017 217 µM -0.257974032297714 0.412608549054616 no 2009 0.398213474146046 2923 1240153 SGTC_801 0866-0028 10.1 µM -0.258659745724096 0.412332209899295 no 2010 0.39794889050208 2832 6849771 SGTC_1129 3453-1384 223 µM -0.258733761411755 0.412302384535392 no 2011 0.397920334232056 3073 1084452 SGTC_190 3970-0790 3.722 µM -0.258781355907882 0.412283206123218 no 2012 0.397901971909894 2926 2832352 SGTC_2134 5324836 1.464 µM -0.260843007720499 0.411452656076865 no 2013 0.397106788408011 2902 699272 SGTC_212 3807-4682 38.772 µM -0.261407834282377 0.411225181029763 no 2014 0.396889008071184 2940 3125501 YBL034C STU1 SGTC_192 3455-0609 60.9 µM -0.261684388527889 0.411113814019608 no 2015 0.396782388694242 2999 3769639 SGTC_435 c-PAF 6.7 µM -0.261821714643934 0.411058516141216 no 2016 0.396729448511837 3048 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_43 0570-0105 72.5 µM -0.261938835934261 0.411011355649819 no 2017 0.396684298935596 2872 1114046 YDL195W SEC31 SGTC_1158 4092-0494 91.8 µM -0.261954238506509 0.411005153688861 no 2018 0.396678361436618 2995 1148199 SGTC_254 nsc-64875 3.808 µM -0.262432436698441 0.410812614682916 no 2019 0.396494033938088 3016 56993 SGTC_2992 9074591 71.4286 µM -0.265520072319642 0.409569945831023 no 2020 0.395304424568172 2982 17741321 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.266388771301081 0.40922048700896 no 2021 0.394969906053245 2811 4000243 SGTC_1953 st076800 12.1 µM -0.266584895805154 0.409141600331462 no 2022 0.394894393151062 2908 297591 SGTC_476 mead acid 10 µM -0.267231244421721 0.408881647177243 no 2023 0.394645560520502 2871 5312531 An omega 9 fatty acid. SGTC_788 1182-0090 188 µM -0.268472408465841 0.408382579316649 no 2024 0.394167855194182 3078 5715185 SGTC_2289 7946404 165.07 µM -0.268637319999432 0.408316280110492 no 2025 0.394104395194683 2863 1246120 YPR165W RHO1 SGTC_657 3534-0529 86.7 µM -0.26877546686796 0.408260743093757 no 2026 0.394051236733473 3038 1049549 SGTC_2373 9071805 200 µM -0.269948881562337 0.407789088013855 no 2027 0.393599790291922 3021 10149009 SGTC_2954 9074818 52.69 µM -0.272290615990075 0.406848225797875 no 2028 0.39269928554301 3055 16648742 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.273591349853202 0.406325848647889 no 2029 0.392199341136258 2915 65057 A dermal irritant. YDR527W RBA50 SGTC_3008 9078912 71.4286 µM -0.274354990045764 0.406019246913489 no 2030 0.391905914536648 2923 16648731 SGTC_1996 st072960 66.8 µM -0.274528497264878 0.405949591748285 no 2031 0.391839253439104 3017 1719405 SGTC_2803 7707263 71.43 µM -0.275009854371131 0.405756364611533 no 2032 0.391654333711297 2912 2199229 SGTC_1353 1498-1206 8.11 µM -0.275329622693286 0.405628015391452 no 2033 0.39153150399072 2906 6756808 SGTC_3158 9100007 49.47 µM -0.275420218849811 0.405591653576857 no 2034 0.391496706071841 2916 19297233 SGTC_1019 4262-0212 3.4 µM -0.275807808064976 0.405436099367157 no 2035 0.39134784313825 2977 4677213 SGTC_1569 carminic acid 40.6 µM -0.276029662590276 0.405347067475439 no 2036 0.391262641746714 3051 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1009 4106-0057 9.87 µM -0.279228319657652 0.404063968844036 no 2037 0.390034805832727 3032 2928005 SGTC_2074 5212007 75.395 µM -0.279321102572298 0.40402676554251 no 2038 0.389999206503428 2978 758611 SGTC_924 2046-0044 21.3 µM -0.279963911374601 0.403769041410699 no 2039 0.389752596337923 2860 3623589 SGTC_2844 9010103 25.97 µM -0.280539228499996 0.403538412432163 no 2040 0.38953191662356 3076 2480525 SGTC_1734 st037168 69.4 µM -0.280735121135246 0.403459892056061 no 2041 0.389456784396914 2983 708907 SGTC_970 1315-0089 19.5 µM -0.280996569633696 0.4033551007419 no 2042 0.389356515457511 2909 6811083 YLR033W RSC58 SGTC_2158 5657123 3.6195 µM -0.281317379854697 0.403226526105422 no 2043 0.389233490581725 2872 2858827 SGTC_527 4476-4215 268 µM -0.28155295049865 0.403132120530891 no 2044 0.389143160599773 2919 4418754 SGTC_2214 7179297 48.276 µM -0.282019813377278 0.402945040653051 no 2045 0.388964158905916 2898 769744 SGTC_2487 5918373 44.05 µM -0.284946014386289 0.401772969896884 no 2046 0.387842751111562 2966 2876279 SGTC_1139 k015-0024 46.9 µM -0.285217178407223 0.401664401456676 no 2047 0.387738880127957 3037 2766652 SGTC_1294 1000-1494 117 µM -0.286735188615752 0.401056762099697 no 2048 0.387157545889497 2925 712797 YDL207W GLE1 SGTC_1117 retinoic acid 1.10837 µM -0.287716226022355 0.40066419301869 no 2049 0.386781984210337 3074 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2875 9039966 71.43 µM -0.289592535012862 0.39991365435439 no 2050 0.38606398930045 2997 6463691 SGTC_1341 1486-1360 280 µM -0.289692385694627 0.399873723612998 no 2051 0.386025791001798 2887 3976547 SGTC_559 1550-0661 158 µM -0.289833822462833 0.399817164198628 no 2052 0.385971685661792 2985 5830875 SGTC_274 sirtinol 40.1 µM -0.291033012854691 0.399337702276556 no 2053 0.385513035584024 2943 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_731 3966-0296 387 µM -0.291504338513015 0.399149297729648 no 2054 0.385332813117724 2925 660956 SGTC_955 1216-0110 33 µM -0.291990241311145 0.398955090805937 no 2055 0.38514704265927 2863 3619719 SGTC_313 3474-0040 5.03 µM -0.292235630304619 0.398857022581859 no 2056 0.385053235501611 2905 1043375 YIL048W NEO1 SGTC_3317 9138495 8.753 µM -0.292712192905374 0.398666585472211 no 2057 0.384871074657742 2925 17020139 SGTC_2987 9018338 71.43 µM -0.293257286134779 0.398448792715749 no 2058 0.384662749884905 2977 5055682 SGTC_690 glyoxal 20.3 µM -0.293683004803186 0.398278718222921 no 2059 0.384500071065791 2949 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_528 3492-0019 172 µM -0.294309134992164 0.398028614496956 no 2060 0.384260846449809 3000 2869262 SGTC_711 k292-0785 179 µM -0.294644601631418 0.39789463170864 no 2061 0.384132693346968 2900 4146315 SGTC_1668 st014914 51.6 µM -0.295674744316144 0.397483275988773 no 2062 0.383739243183425 2993 2839556 SGTC_1612 st002233 45.4 µM -0.297316374249835 0.396827977410275 no 2063 0.383112490859261 2949 1035021 SGTC_2082 5219693 150 µM -0.297380779140414 0.396802274475938 no 2064 0.383087908159113 2918 2834649 SGTC_882 0843-0131 351 µM -0.298684174791756 0.396282207165533 no 2065 0.382590516430925 2922 5425421 SGTC_1620 st003704 16.5 µM -0.300162549068788 0.39569254507751 no 2066 0.382026585088611 2951 2834414 SGTC_1328 1441-0025 69.2 µM -0.301091335918742 0.395322212565625 no 2067 0.381672423799969 2908 4562601 SGTC_1011 4112-3381 17.4 µM -0.301217389538128 0.395271958845082 no 2068 0.381624365163513 3103 2877139 SGTC_1757 st041620 31.8375 µM -0.304591877117745 0.393927303843633 no 2069 0.38033850367608 3009 5289815 SGTC_562 3772-2733 112 µM -0.304716940352111 0.393877493231971 no 2070 0.380290873153036 3063 2876874 YIL048W NEO1 SGTC_1192 1488-0095 21.4 µM -0.304757679518515 0.393861267872627 no 2071 0.380275357971448 3023 915875 SGTC_155 k072-0202 43.6 µM -0.308645693590854 0.392313623887956 no 2072 0.378795529120354 2935 5857737 SGTC_939 1165-0479 45.3 µM -0.309047743629694 0.392153682473137 no 2073 0.378642604538852 3078 1377347 SGTC_2895 9054447 58.44 µM -0.310170056211607 0.391707306525644 no 2074 0.378215820029171 2958 2697450 SGTC_2948 9070189 9.45 µM -0.311137384410236 0.391322686658995 no 2075 0.377848090974961 3090 6473636 YDL196W YDL196W SGTC_2717 st081029 62.2815 µM -0.311311764547011 0.391253362573736 no 2076 0.377781812266377 3068 5292846 SGTC_2610 ononetin 44.17 µM -0.312081843638045 0.390947262230764 no 2077 0.377489162305853 3012 259632 SGTC_1888 azatryptophan 97.5 µM -0.315273449011293 0.389679346475631 no 2078 0.37627702121407 3070 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3214 9129694 49.47 µM -0.3157951650531 0.38947219772893 no 2079 0.376078994099066 3122 17158655 SGTC_578 3460-0051 92 µM -0.316287666209686 0.389276677641332 no 2080 0.375892085975459 3076 2876744 SGTC_2464 5717415 7.67 µM -0.316851241688635 0.389052975852952 no 2081 0.375678240299075 2982 5285744 SGTC_265 mycophenolic acid 32.932 µM -0.317544923768025 0.388777680935893 no 2082 0.375415078803957 3219 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2371 9071574 200 µM -0.318058807944625 0.388573776677881 no 2083 0.375220164431476 3069 45596039 SGTC_3080 9117754 49.47 µM -0.318928538006466 0.388228746196295 no 2084 0.374890351632269 3186 9550191 SGTC_174 3553-0389 74.3 µM -0.319434502312524 0.388028065732161 no 2085 0.374698525545931 3108 738071 SGTC_3344 9148862 3.898 µM -0.319926715538441 0.387832868043678 no 2086 0.374511942650381 3138 4905352 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.319937035181547 0.387828775871516 no 2087 0.374508031105364 3035 4213774 SGTC_1385 3091-4834 14.1 µM -0.320521110337955 0.387597185846392 no 2088 0.374286665027605 3061 4072814 SGTC_1244 0416-0015 52.5 µM -0.321553344532412 0.387187995346532 no 2089 0.373895546822484 2984 96201 SGTC_2911 7942208 15.64 µM -0.323049500240543 0.386595123147657 no 2090 0.373328877166929 3054 1243384 SGTC_45 0kpi-0036 14.9 µM -0.324827100234688 0.385891068816465 no 2091 0.372655966384854 3121 2795021 SGTC_2150 5556613 200 µM -0.324863595782611 0.385876617946689 no 2092 0.372642155051742 3005 743190 SGTC_2588 indole-3-carbinol 100 µM -0.324944102273029 0.385844740952448 no 2093 0.372611688847291 3115 3712 Induces cell cycle arrest. SGTC_2181 6316240 54.2555 µM -0.325993317254363 0.385429368985281 no 2094 0.372214705627615 3058 12779990 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.32811650818737 0.384589224854798 no 2095 0.371411786308783 3107 5024745 SGTC_783 0848-0141 92.7 µM -0.328449026724673 0.384457696630977 no 2096 0.37128608955567 2942 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1175 0741-0056 27.6 µM -0.328821795429628 0.38431026320449 no 2097 0.371145193985586 3172 765927 SGTC_2544 sphondin 68.51 µM -0.329715972279573 0.383956676353645 no 2098 0.370807291951835 3180 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_719 2810-4230 27.3 µM -0.330282268640493 0.383732794130763 no 2099 0.370593344744012 2985 721079 SGTC_2353 9059630 146.67 µM -0.330951820929862 0.383468140299333 no 2100 0.370340438991602 3090 4779114 SGTC_1045 1348-1485 165 µM -0.331824404388507 0.383123315972691 no 2101 0.370010927673704 2979 6810614 SGTC_449 xestospongin c 11.1929 µM -0.332804455934799 0.382736133205196 no 2102 0.369640947226264 3095 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1618 st003135 44.5 µM -0.33325869730956 0.382556718649865 no 2103 0.369469506915665 3063 1270615 SGTC_576 1073-0113 22.7 µM -0.333638850491688 0.382406586542554 no 2104 0.369326049002894 3064 5439563 SGTC_74 000s-0487 160.283 µM -0.333872318647378 0.382314392821325 no 2105 0.369237954444986 2998 677548 SGTC_488 nitrendipine 139 µM -0.334027908319713 0.382252956065289 no 2106 0.369179249594036 2994 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2507 purpurin 79.67 µM -0.334858962445057 0.381924852968335 no 2107 0.36886573993779 2977 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1282 0886-0010 32.4 µM -0.335450329309159 0.381691430867821 no 2108 0.368642703822171 3177 2836211 YNL267W PIK1 SGTC_2770 toltrazuril 17.5 µM -0.336612678690799 0.381232758131673 no 2109 0.368204448619191 3044 68591 Kills coccidiodes. SGTC_2897 9048598 12.99 µM -0.337011673307329 0.381075349956056 no 2110 0.368054050160356 3008 6467404 SGTC_119 0121-0043 24.815 µM -0.338440535509404 0.380511808201292 no 2111 0.367515615757671 3024 1092378 SGTC_1392 3455-1037 33.9 µM -0.338747323595602 0.380390844315045 no 2112 0.367400043519285 3156 981132 SGTC_929 2805-0021 398 µM -0.339774297547371 0.379986002542446 no 2113 0.367013252585104 3080 3098024 SGTC_100 0086-0128 49.5915 µM -0.340004255789399 0.37989536906899 no 2114 0.366926661502269 3050 93297 SGTC_3108 9121785 49.47 µM -0.340649993820508 0.37964089953419 no 2115 0.366683544195095 2934 17140271 SGTC_3136 9095672 49.47 µM -0.340998772680195 0.3795034760028 no 2116 0.366552252843226 2951 17217380 SGTC_255 tunicamycin 200.472 nM -0.3427599361455 0.378809786872343 no 2117 0.365889534196877 3075 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2688 kanamycin b 96.69 µM -0.347622253768145 0.37689664350241 no 2118 0.364061945667423 3171 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1177 0983-0204 23.6 µM -0.348082995027981 0.376715514588049 no 2119 0.36388892736871 3164 766818 SGTC_1833 st055984 71 µM -0.348944552967442 0.376376887449495 no 2120 0.363565468221521 3046 676288 SGTC_3185 9108267 49.47 µM -0.349599414113875 0.376119564131701 no 2121 0.363319675345263 3098 4910486 SGTC_70 0141-0289 43.283 µM -0.350097784052032 0.375923769881562 no 2122 0.363132656930715 3077 352408 SGTC_2761 levamisole 97.89 µM -0.350358943261 0.375821181195298 no 2123 0.363034667293699 3172 26879 An alkaline phosphatase inhibitor. SGTC_1745 st081495 74 µM -0.350517396549998 0.375758941775629 no 2124 0.362975218350085 3042 13842402 YBL026W LSM2 SGTC_1243 0416-0003 5.65 µM -0.35152663064013 0.375362597124129 no 2125 0.362596648652261 3029 2141977 SGTC_53 0973-0023 39.979 µM -0.351603743896074 0.375332318744442 no 2126 0.362567728530031 3177 674768 SGTC_1079 idarubicin 2.36 µM -0.352001352403071 0.375176210680532 no 2127 0.362418624117615 3155 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3168 9103419 49.47 µM -0.352363027705887 0.375034228376054 no 2128 0.362283012890177 3100 16649256 SGTC_387 norethindrone acetate 66.7 µM -0.352590483596983 0.374944945046485 no 2129 0.362197736479779 3049 541197 SGTC_794 k038-0031 316 µM -0.352732580059668 0.374889171279754 no 2130 0.362144465989226 3093 6624242 SGTC_837 0091-0265 12.5 µM -0.353015069768896 0.374778300041714 no 2131 0.362038571457174 3029 759367 SGTC_3051 9093778 49.47 µM -0.353409217551732 0.374623622666322 no 2132 0.361890838252744 3079 17217378 SGTC_880 0833-0487 87.2 µM -0.354811766863654 0.374073377015497 no 2133 0.361365306258678 3021 76075 SGTC_2450 5739737 12.93 µM -0.354818351182727 0.374070794471126 no 2134 0.361362839745393 3120 2262825 SGTC_630 4356-0227 183 µM -0.356002184458657 0.373606555665156 no 2135 0.36091946462802 3064 779312 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.3564113744849 0.373446134889358 no 2136 0.360766256166778 2980 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1308 1187-1617 41.4 µM -0.358444131576135 0.372649528837396 no 2137 0.360005485206229 3012 2882570 SGTC_1183 1254-0324 198 µM -0.358678230347446 0.372557824044893 no 2138 0.35991790793263 3166 5799357 SGTC_3100 9120536 49.47 µM -0.358791455171584 0.372513472456751 no 2139 0.359875552717425 3088 16421196 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.361240782917395 0.371554454706057 no 2140 0.358959728611017 3083 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1822 st052468 42 µM -0.361449515395611 0.371472763670672 no 2141 0.358881719179963 3103 2873678 SGTC_3286 9117135 37.221 µM -0.362030311419064 0.37124548965817 no 2142 0.358664689701684 3062 3438150 SGTC_1109 tnp00067 928.257 nM -0.362790793648234 0.370947969677407 no 2143 0.358380584816021 3064 676295 SGTC_2062 5245942 200 µM -0.363619047625572 0.370624023415865 no 2144 0.358071250575119 3054 1376160 SGTC_2249 haloperidol 116.36 µM -0.364351434055366 0.370337649205473 no 2145 0.35779779830163 3024 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3154 9100113 49.47 µM -0.364471460423537 0.370290723921943 no 2146 0.357752990822595 3055 25237525 SGTC_1546 5-methoxyflavanone 78.7 µM -0.364720790476151 0.37019325248316 no 2147 0.357659918781523 3112 147795 SGTC_3279 9140807 49.47 µM -0.36486143148256 0.370138274896547 no 2148 0.357607422844394 3077 45595718 SGTC_1590 st077108 57.8 µM -0.366123512480657 0.369645037162908 no 2149 0.357136456677414 3146 5489485 SGTC_2438 5259590 200 µM -0.367715064989347 0.369023343423717 no 2150 0.356542853091601 3143 1201127 SGTC_2238 6671620 73.2395 µM -0.368638397542587 0.368662827266205 no 2151 0.356198635548921 2975 729941 SGTC_1376 2910-0861 41.3 µM -0.368903979368818 0.368559151951356 no 2152 0.356099648565641 3053 1112859 SGTC_3092 9117248 49.47 µM -0.369517700430792 0.368319609953324 no 2153 0.355870941119385 3103 17141857 SGTC_3060 1327-0027 12.5 µM -0.370367169047852 0.367988137578401 no 2154 0.355554466281925 3112 16000455 YPR107C YTH1 SGTC_1700 st030840 7.9285 µM -0.373957763372567 0.366588134820459 no 2155 0.354217870002812 3161 5499307 SGTC_2787 5284540 71.43 µM -0.374334838091392 0.366441212802617 no 2156 0.354077608003757 3103 736958 SGTC_3187 9109394 49.47 µM -0.37595108076717 0.365811687878757 no 2157 0.353476632213238 3104 17098090 SGTC_3210 9128157 49.47 µM -0.376192821501488 0.365717561110208 no 2158 0.353386775869485 3131 17590849 SGTC_2924 9010168 62.78 µM -0.377035171618543 0.365389637817669 no 2159 0.353073733629327 3154 2993929 SGTC_3198 9112019 49.47 µM -0.377907461093909 0.365050162945826 no 2160 0.352749669807203 3059 45595555 SGTC_413 propylparaben 100 µM -0.379579327876933 0.364399806843962 no 2161 0.35212885414175 3060 7175 A pharmaceutical preservative. SGTC_3141 9094609 49.47 µM -0.381614387292817 0.363608695465551 no 2162 0.351373705482396 3020 25236309 YDL196W YDL196W SGTC_1093 fluphenazine 7.97 µM -0.381681578554887 0.363582585349268 no 2163 0.351348782830976 3090 6602611 An atypical antipsychotic. SGTC_2462 5162487 171.77 µM -0.381701865495476 0.363574702091919 no 2164 0.351341258103909 3164 2259986 SGTC_3043 9092303 49.47 µM -0.383092989114859 0.363034266396827 no 2165 0.350825408859605 3125 25236084 SGTC_1587 estradiol valerate 56.1 µM -0.383456798651887 0.362892975459785 no 2166 0.35069054819644 3222 13791 A steroid. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.383957277691556 0.362698637352085 no 2167 0.350505056219259 3059 803109 SGTC_1339 1486-1321 22.7 µM -0.383995470241287 0.362683808476701 no 2168 0.350490902421198 3102 3469382 SGTC_1396 3511-0007 98.6 µM -0.386801864825923 0.361594745286598 no 2169 0.349451448276545 3165 X1396 SGTC_2002 4023503 131 µM -0.387237091605227 0.361425949174817 no 2170 0.349290346446661 3259 4736863 YCR052W RSC6 SGTC_1089 terbinafine 2.25 µM -0.387886104852445 0.361174289322635 no 2171 0.349050160696282 3189 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.388028632974088 0.36111903099384 no 2172 0.348997422217798 3181 17037758 SGTC_2729 fluphenazine 10.66 µM -0.388049352139937 0.361110998388888 no 2173 0.348989755922435 3074 3372 An atypical antipsychotic. SGTC_408 cantharidin 100 µM -0.388434326125719 0.360961759125897 no 2174 0.348847322972624 3102 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1499 4480-0877 67.3 µM -0.388785017575986 0.360825828273662 no 2175 0.348717592436302 3086 2861909 SGTC_941 3237-0776 460 µM -0.390803809698077 0.360043670407927 no 2176 0.347971129375539 3255 760008 SGTC_954 1189-0853 2.85 µM -0.394271249293886 0.358701618829842 no 2177 0.346690393724839 3131 2828194 SGTC_193 1273-0060 1.558 µM -0.394606583362119 0.358571921960718 no 2178 0.346566627105884 3165 2847393 YHR072W ERG7 SGTC_621 3584-0052 32.1 µM -0.394993979934578 0.358422109226582 no 2179 0.34642366540996 3225 2273927 SGTC_375 3970-0961 9.27 µM -0.395383620640797 0.358271450625752 no 2180 0.346279897621776 3119 2898222 SGTC_181 1447-1644 8.07 µM -0.395421760731683 0.358256704551066 no 2181 0.346265826060836 3200 534600 SGTC_2157 5649910 96.377 µM -0.396465842114513 0.357853114325344 no 2182 0.345880700890248 3084 2858091 SGTC_538 2922-0838 53.3 µM -0.396640996118724 0.357785423996848 no 2183 0.345816108295644 3273 777039 SGTC_2903 5923464 63.88 µM -0.39669841527637 0.357763234660115 no 2184 0.345794934464409 3195 2876576 SGTC_1686 st019653 115.5 µM -0.396944430270607 0.357668168879388 no 2185 0.345704219681551 3226 97252 SGTC_2141 5621638 7.665 µM -0.397527542748325 0.357442876249608 no 2186 0.345489240039114 3217 2856238 SGTC_2512 diallyl trisulfide 49.23 µM -0.398037217469198 0.357245997874853 no 2187 0.345301375950826 3166 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1691 st019933 84.6 µM -0.398772877699787 0.35696189228956 no 2188 0.345030281706416 3190 6176082 SGTC_2010 4012422 159 µM -0.399085481527558 0.356841191409705 no 2189 0.344915109796493 3148 952393 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.399338432685236 0.356743533781403 no 2190 0.344821926098827 3199 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.401857100960114 0.355771656916176 no 2191 0.343894597908326 3116 4174840 SGTC_1292 0kpi-0043 232 µM -0.401890930141784 0.355758609633525 no 2192 0.343882148988009 3150 3333905 SGTC_1005 4092-0690 4.4 µM -0.402554945927206 0.355502545390475 no 2193 0.343637829748722 3127 1529343 SGTC_440 fluspirilene 35.1 µM -0.405616704023788 0.354322685491773 no 2194 0.342512126719493 3315 3396 An atypical antipsychotic. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.405998074981604 0.354175820372709 no 2195 0.342372007421672 3186 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1278 0874-0585 172 µM -0.406912635939541 0.353823713355137 no 2196 0.342036077496411 3180 766306 SGTC_3307 9126885 69.2785 µM -0.409371885796009 0.352877520028724 no 2197 0.341133384196272 3112 24824909 SGTC_2990 9074105 71.4286 µM -0.409478552062048 0.35283650084642 no 2198 0.341094251751492 3186 6502001 SGTC_1428 4049-0204 61.7 µM -0.410259536526167 0.352536220506717 no 2199 0.340807785599436 3237 X1428 SGTC_1387 3342-1166 1.8 µM -0.411936510279466 0.351891752313778 no 2200 0.340192979650571 3168 3418228 SGTC_2210 7115885 190.385 µM -0.412670308960027 0.351609883987683 no 2201 0.339924090527911 3151 2927039 SGTC_2678 equilin 100 µM -0.412703971885362 0.351596955267987 no 2202 0.3399117572242 3237 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2253 7938677 135.83 µM -0.412791086587445 0.351563498438954 no 2203 0.339879841242753 3283 2301972 SGTC_1348 1493-0373 93.8 µM -0.414240035792226 0.351007191167311 no 2204 0.339349162029274 3178 3010129 SGTC_122 0236-0016 402.397 µM -0.414270267593213 0.35099558741265 no 2205 0.339338092987476 3167 6808838 SGTC_3274 9138298 49.47 µM -0.415798274272896 0.350409279748491 no 2206 0.338778810883305 3110 17015756 SGTC_2596 sinensetin 100 µM -0.416440771304758 0.350162855109058 no 2207 0.338543749679716 3146 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2665 lovastatin 100 µM -0.417799247617276 0.349642030074105 no 2208 0.338046950517453 3181 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_29 0299-0004 12.984 µM -0.42087683057275 0.348463165845809 no 2209 0.336922512376971 3172 16871 A napthoquinone isolated from Swertia calycina. SGTC_522 1273-0010 11.6 µM -0.421631359404229 0.34817436728005 no 2210 0.336647056507822 3339 5705015 SGTC_1321 1326-2144 215 µM -0.424710432409974 0.346996755293635 no 2211 0.335523888895761 3242 3513030 SGTC_2228 7354201 200 µM -0.425219373724733 0.346802249159296 no 2212 0.335338381159096 3189 753451 SGTC_752 1896-0090 130 µM -0.425820535859782 0.346572550269099 no 2213 0.335119310896505 3165 772567 SGTC_931 2812-0076 566 µM -0.426917372343884 0.346153603838688 no 2214 0.334719755837659 3122 3450959 SGTC_942 3253-1115 227 µM -0.427011398556964 0.346117698443652 no 2215 0.334685512713872 3324 46497897 SGTC_525 k781-2675 26.7 µM -0.427383271245286 0.345975706539164 no 2216 0.334550094991541 3259 3651118 YDL195W SEC31 SGTC_1722 st034304 3.6505 µM -0.427551953717127 0.345911305759868 no 2217 0.334488676235054 3162 4036148 YLR033W RSC58 SGTC_2250 alverine citrate 130 µM -0.42764776676473 0.345874727566189 no 2218 0.334453791842716 3183 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2452 5863136 48.41 µM -0.42916644548598 0.345295139481553 no 2219 0.333901050013526 3131 2184096 SGTC_1693 xanthone 101.9 µM -0.429173739177757 0.345292356793139 no 2220 0.33389839625269 3180 7020 An insecticide. SGTC_3254 9136651 49.47 µM -0.429498954643678 0.345168289129592 no 2221 0.333780077231176 3187 16454030 SGTC_584 0986-0246 15.4 µM -0.429696116891418 0.34509308106763 no 2222 0.333708354234815 3287 53315 YDR232W HEM1 SGTC_2774 tamoxifen 10.92 µM -0.429857085584915 0.34503168366934 no 2223 0.333649802108935 3241 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1473 k844-0725 134 µM -0.431004156197062 0.344594281072535 no 2224 0.333232674229488 3231 54682906 SGTC_824 1304-0008 100 µM -0.431587651794346 0.344371861360445 no 2225 0.333020567352752 3173 768245 SGTC_3184 9108758 49.47 µM -0.432359997560739 0.344077537574162 no 2226 0.332739893567703 3172 902885 SGTC_2485 5633444 17.78 µM -0.43301115576857 0.343829469031627 no 2227 0.332503332666827 3208 5724239 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.433088964585863 0.343799831082846 no 2228 0.332475069765235 3207 2346 DNA damaging agent; causes G2/M arrest. SGTC_1329 1447-1697 50.6 µM -0.435248785829702 0.342977523050232 no 2229 0.331690927281937 3240 2840515 SGTC_2284 7945075 39.21 µM -0.43549953899797 0.342882101955821 no 2230 0.331599936773703 3279 1245402 SGTC_177 1327-0068 8.361 µM -0.435980697169819 0.342699031083834 no 2231 0.331425367300547 3260 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1976 st070609 63.5 µM -0.436673073956133 0.342435660662066 no 2232 0.331174229656515 3163 682556 SGTC_3173 9105693 49.47 µM -0.436925242070018 0.34233975846938 no 2233 0.331082782553489 3343 17096658 SGTC_106 0092-0003 11.579 µM -0.438981738113003 0.34155803132005 no 2234 0.330337384363982 3213 1072148 SGTC_371 0195-0006 7.36 µM -0.440134290780363 0.34112021308276 no 2235 0.32991992372152 3156 3928593 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.441330050087062 0.34066620799742 no 2236 0.329487037181473 3336 16725076 SGTC_3332 9141069 11.198 µM -0.441941215840457 0.340434250056633 no 2237 0.329265872266982 3139 17332883 SGTC_1295 1013-0063 9.78 µM -0.442184025652672 0.340342112319715 no 2238 0.329178022316093 3308 6826038 SGTC_878 0828-0289 13.7 µM -0.44267718532125 0.340155005005572 no 2239 0.328999623420185 3192 745350 YLR208W SEC13 SGTC_407 eburnamonine 100 µM -0.442950467547825 0.340051337267149 no 2240 0.328900781235906 3159 3195 SGTC_84 0443-0269 128.823 µM -0.443076304396996 0.340003605986749 no 2241 0.328855271910622 3291 6150058 SGTC_1075 aripiprazole 15.2 µM -0.443097182555823 0.339995686922895 no 2242 0.328847721498737 3179 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1201 1889-3372 45.9 µM -0.444142605862875 0.339599249285675 no 2243 0.328469742254062 3159 5392199 SGTC_1560 lithocholic acid 53.1 µM -0.444308648309845 0.339536300220491 no 2244 0.328409724721896 3245 9903 A bile acid which acts as a detergent. SGTC_1160 4092-0570 10.5 µM -0.44517972387636 0.339206136396778 no 2245 0.328094939214707 3192 4994975 SGTC_2007 4011539 71.82 µM -0.449589596245517 0.337536560804455 no 2246 0.326503195566494 3176 45595301 SGTC_2537 larixol 68.93 µM -0.450136581016602 0.337329694554269 no 2247 0.326305980662213 3290 6708759 SGTC_2361 9034121 116 µM -0.450389224020401 0.33723416313041 no 2248 0.326214906826037 3203 6496917 SGTC_756 0508-1999 28.3 µM -0.451157125135129 0.336943862566993 no 2249 0.325938154164752 3183 6753853 SGTC_284 0988-0104 32.6 µM -0.45158226908148 0.336783181111979 no 2250 0.325784972898337 3250 4666532 SGTC_1646 st011709 75.6 µM -0.45188156443209 0.336670081495004 no 2251 0.325677153080335 3295 5757843 SGTC_1667 st014849 34.6 µM -0.454844370463634 0.335551275936626 no 2252 0.32461060324155 3250 5348460 SGTC_1870 st057514 26.5 µM -0.455322454654271 0.335370879492856 no 2253 0.324438637057853 3160 5393161 SGTC_451 chloral hydrate 100 µM -0.456383993228391 0.33497046280245 no 2254 0.324056937054533 3287 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_846 0335-0850 148 µM -0.458029280287984 0.334350224453085 no 2255 0.323465702642211 3264 6819598 SGTC_325 2810-4341 181 µM -0.45842199111373 0.33420224754298 no 2256 0.32332464767909 3322 774970 SGTC_2492 derrusnin 100 µM -0.458856721197072 0.334038467453772 no 2257 0.323168529735303 3232 1715307 Part of coumarin class of compounds. SGTC_902 1120-0002 2.07 µM -0.460280953520993 0.333502124062265 no 2258 0.322657285276139 3258 3280475 SGTC_3207 9114163 49.47 µM -0.46064070613807 0.333366700679902 no 2259 0.322528200935375 3425 849233 SGTC_1359 1582-0056 520 nM -0.462344631084794 0.332725579409664 no 2260 0.321917099298136 3304 3661189 SGTC_868 0527-0199 213 µM -0.463039320585382 0.332464334702828 no 2261 0.32166809142805 3211 2849450 SGTC_582 0987-0078 156 µM -0.464068451846974 0.332077469503872 no 2262 0.321299351859189 3349 1625765 SGTC_1166 k206-0078 225 µM -0.464258406042118 0.33200608254561 no 2263 0.32123131017051 3242 5404595 SGTC_2972 9093619 59.92 µM -0.464631004933298 0.331866073334192 no 2264 0.321097862488991 3160 25236256 SGTC_697 0508-1955 564 µM -0.464941667433485 0.33174935552881 no 2265 0.320986615215922 3366 6243113 SGTC_891 0929-0073 133 µM -0.466717558893967 0.331082456008626 no 2266 0.320350982721897 3328 5603632 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.466976059400038 0.330985426059295 no 2267 0.320258503300842 3292 364106 SGTC_184 1494-0393 24.714 µM -0.468291021655716 0.330492021748526 no 2268 0.319788244074681 3169 3090647 SGTC_1084 voriconazole 435 nM -0.468359249694958 0.330466429036246 no 2269 0.319763852131915 3332 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1773 st048542 73.5835 µM -0.468705573956408 0.330336533131732 no 2270 0.319640051104348 3202 3237138 SGTC_822 1487-0950 154 µM -0.469821544742 0.329918104890566 no 2271 0.3192412601933 3355 1958375 SGTC_1960 st011366 51.8 µM -0.470497276920244 0.329664845500673 no 2272 0.318999889637711 3257 3972846 SGTC_1000 4048-0884 8.67 µM -0.470902061076192 0.329513172803581 no 2273 0.318855338064914 3333 13040088 SGTC_718 1130-0073 349 µM -0.471107808335509 0.329436090015486 no 2274 0.318781874676876 3403 6740020 SGTC_430 0958-0115 16.4 µM -0.471617053882702 0.329245333391828 no 2275 0.318600075891817 3210 6833180 SGTC_2722 naftopidil 47.16 µM -0.471632238333343 0.32923964618025 no 2276 0.318594655768955 3330 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_88 0180-0332 8.668 µM -0.47190105837229 0.32913896838013 no 2277 0.318498706295501 3217 3101745 SGTC_473 2-arachidonoylglycerol 10 µM -0.471924530336165 0.329130178307751 no 2278 0.318490329065539 3188 5282280 An endocannabinoid. SGTC_2105 5350118 200 µM -0.47329715047228 0.328616306914664 no 2279 0.3180005974082 3273 2133313 SGTC_2683 piperine 63.03 µM -0.473339463118598 0.328600471360394 no 2280 0.317985505897722 3246 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_250 brefeldin a 552.239 µM -0.473490994119842 0.328543763242251 no 2281 0.317931462320356 3244 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2156 5649887 115 µM -0.474352340568123 0.328221492795583 no 2282 0.317624336539936 3331 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2159 5658611 73.75 µM -0.474840064252302 0.328039068952183 no 2283 0.317450487087991 3353 793844 SGTC_1064 honokiol 6.76 µM -0.475391607825939 0.327832823897461 no 2284 0.317253937496584 3292 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1919 st067113 52.3 µM -0.478148264235368 0.326802783576447 no 2285 0.316272341107641 3340 1268243 SGTC_2113 5491891 107.031 µM -0.478449956487788 0.326690134460483 no 2286 0.316164992247032 3270 789979 SGTC_3194 9111903 49.47 µM -0.479569652907392 0.326272188287792 no 2287 0.31576671470515 3393 17087251 SGTC_1486 3970-0793 4.53 µM -0.479586841951285 0.326265773876297 no 2288 0.315760602204158 3344 2844330 SGTC_2727 riluzole 51.77 µM -0.483327905163362 0.324870952023158 no 2289 0.314431464658639 3307 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3074 9116018 49.47 µM -0.484266851691486 0.324521258339662 no 2290 0.314098248961647 3233 17027303 SGTC_1497 4476-2978 41.3 µM -0.485622347697735 0.324016701169925 no 2291 0.313617474387968 3334 1528379 SGTC_1516 st013856 110 µM -0.485759415760271 0.32396569820895 no 2292 0.313568875956347 3323 5281404 A mutagen and neurotoxin. SGTC_3138 9097216 49.47 µM -0.488480356409115 0.322953922427262 no 2293 0.312604818142107 3345 25237486 SGTC_2528 xanthyletin 44.79 µM -0.489522737553651 0.322566661615839 no 2294 0.312235830514851 3230 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1951 sophoraflavanone G 9.2 µM -0.490752723857195 0.322109950049977 no 2295 0.311800675538834 3249 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3031 9088762 49.47 µM -0.491181293516158 0.321950879023687 no 2296 0.311649114195623 3225 205253 SGTC_1717 st033143 58.0435 µM -0.491232006080639 0.32193205833778 no 2297 0.311631182081682 3411 674616 SGTC_1561 5-methoxyflavone 52.9 µM -0.491860729789349 0.321698761379557 no 2298 0.311408900615664 3326 94525 SGTC_613 3914-0030 117 µM -0.492018178019662 0.321640348954558 no 2299 0.311353246503926 3172 1145395 SGTC_1186 1319-0216 26 µM -0.4923719828459 0.321509105402533 no 2300 0.311228200851877 3418 4565136 SGTC_213 1246-0773 967 nM -0.492375652439761 0.321507744287002 no 2301 0.31122690401715 3312 6251622 SGTC_2354 9060492 162 µM -0.493573613342204 0.321063528145062 no 2302 0.310803669868144 3378 6471895 SGTC_2881 9058953 51.95 µM -0.494033248475216 0.320893158648607 no 2303 0.310641349245472 3236 17122249 SGTC_709 3807-1509 243 µM -0.494437862497017 0.320743214618371 no 2304 0.310498489885504 3336 1886677 YPL242C IQG1 SGTC_2030 5175110 200 µM -0.494460440305 0.320734848474558 no 2305 0.310490519052847 3384 2831986 SGTC_2152 5568786 200 µM -0.49500367798548 0.320533580724756 no 2306 0.310298762139458 3319 5399883 SGTC_1255 0566-0045 221 µM -0.49532861943562 0.320413216215113 no 2307 0.310184086029598 3399 2788469 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.496462340570515 0.319993412266017 no 2308 0.309784125524843 3325 5357218 A potent inhibitor of glutathione S-transferases. SGTC_996 3970-0799 1.8 µM -0.497127465475707 0.31974723132635 no 2309 0.309549583750208 3339 6615648 YGL040C HEM2 SGTC_1324 1418-0026 34.4 µM -0.497526290996755 0.319599653145442 no 2310 0.309408983820344 3343 1372513 SGTC_2645 abamectin 100 µM -0.497599467249763 0.319572578695054 no 2311 0.309383189662835 3345 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_917 harmaline 728.087 nM -0.498021100941939 0.319416597363628 no 2312 0.309234584803754 3303 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2398 5228213 48.84 µM -0.499936763121223 0.318708310148094 no 2313 0.308559802590335 3439 80771 YMR134W ERG29 SGTC_3293 9120939 62.045 µM -0.501241767003194 0.318226183414442 no 2314 0.308100491424349 3385 934087 SGTC_1065 prochlorperazine maleate 2.48 µM -0.5019062319611 0.317980818573116 no 2315 0.307866740679009 3397 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2619 obliquin 87.91 µM -0.504782150853149 0.316919759401645 no 2316 0.3068559268681 3327 6708593 A bioactive alkalod. YER133W GLC7 SGTC_702 1488-0190 94 µM -0.505630840289231 0.316606925711508 no 2317 0.306557913613935 3369 949357 SGTC_2469 5655019 90.81 µM -0.508242318085824 0.315645137516142 no 2318 0.305641708325409 3405 2788239 SGTC_2194 5927483 104.545 µM -0.508821298340075 0.315432072006186 no 2319 0.305438744547281 3307 760979 SGTC_1512 0259-0544 12.2 µM -0.508932587763069 0.315391124377337 no 2320 0.305399738456137 3335 18476 SGTC_1694 st024011 44.9 µM -0.509901509004469 0.315034717091839 no 2321 0.305060232359816 3399 2787533 SGTC_2294 7971431 200 µM -0.511058621041662 0.314609311389496 no 2322 0.304655004699311 3350 5741572 SGTC_1685 st024049 53.0905 µM -0.51156673588484 0.314422583527299 no 2323 0.304477135468391 3356 1941139 SGTC_1751 st044839 27.194 µM -0.512254803585481 0.314169800195907 no 2324 0.304236346146212 3396 5291326 SGTC_2797 7859098 81.82 µM -0.514739178391159 0.313257812948299 no 2325 0.303367645993393 3305 972681 SGTC_1022 4477-0945 21.3 µM -0.515877956887757 0.312840160597723 no 2326 0.30296982527803 3347 4648966 SGTC_246 cycloheximide 667 µM -0.517999434891355 0.312062739232676 no 2327 0.302229331806041 3278 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_646 4092-0839 27.3 µM -0.518482964214708 0.311885665504507 no 2328 0.302060671536823 3454 877796 SGTC_3161 9100388 49.47 µM -0.519679648261633 0.311447613705737 no 2329 0.301643437026516 3360 25236368 SGTC_3032 9089427 49.47 µM -0.519730150753162 0.311429132895274 no 2330 0.301625834586183 3385 17173707 SGTC_2331 7980721 200 µM -0.520246783241859 0.311240104431078 no 2331 0.30144579095375 3316 2981221 SGTC_309 k408-0051 1.48 µM -0.520800668581443 0.311037500958472 no 2332 0.301252818648996 3368 3640463 SGTC_676 falcarinol 140 µM -0.521276022408898 0.310863668858571 no 2333 0.301087250910382 3469 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_257 daunorubicin 18.5 µM -0.522863474962782 0.310283459429576 no 2334 0.300534631895265 3410 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2052 5265182 7.135 µM -0.523409473661209 0.310084007432866 no 2335 0.300344666454614 3404 1239884 SGTC_735 3076-0345 636 µM -0.524939939696322 0.30952522982193 no 2336 0.29981247175422 3454 2888990 SGTC_2956 9076196 2.52 µM -0.52575746578737 0.309226928878709 no 2337 0.299528365405664 3450 16423868 SGTC_1148 3909-7663 27.7 µM -0.525851356607907 0.30919267780807 no 2338 0.299495744317655 3451 4084526 SGTC_2684 capsaicin 100 µM -0.525906915348427 0.309172410938394 no 2339 0.299476441947725 3427 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1102 cgs 12066b 26.1 µM -0.526149495459403 0.30908392870396 no 2340 0.299392170708175 3371 6438352 A 5-HT1B full agonist. SGTC_2526 patulin 37.61 µM -0.526924270887883 0.308801399918999 no 2341 0.29912308925822 3434 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2167 5876490 200 µM -0.527958211129917 0.308424540576823 no 2342 0.298764170320173 3452 686534 SGTC_2128 5255449 168.493 µM -0.528219799596108 0.308329226551867 no 2343 0.298673394314583 3346 736008 SGTC_144 4161-2749 112.381 µM -0.529384776877736 0.307904905034775 no 2344 0.298269278154699 3349 797501 YMR168C CEP3 SGTC_3258 9138477 49.47 µM -0.5297839039816 0.307759589354046 no 2345 0.298130883198701 3405 4970355 SGTC_230 MPP+ 141.667 µM -0.530026103514666 0.307671423144583 no 2346 0.298046916211527 3385 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3299 9121982 43.1275 µM -0.530274797128337 0.307580904497083 no 2347 0.297960709038619 3349 17594604 YPL160W CDC60 SGTC_1777 st045864 34.765 µM -0.530810877086647 0.307385823801469 no 2348 0.297774920909614 3418 4691462 SGTC_1998 st075797 76.8 µM -0.530941041859451 0.307338464767259 no 2349 0.297729817946059 3433 24208315 SGTC_1896 st058441 89 µM -0.530951250135304 0.307334750733161 no 2350 0.297726280842066 3335 688759 SGTC_2258 7960471 200 µM -0.533796562142868 0.306300324172149 no 2351 0.296741146276732 3377 2974708 SGTC_2478 5763493 32.33 µM -0.533800538728502 0.306298879542986 no 2352 0.296739770505334 3350 1365576 YLR208W SEC13 SGTC_93 0109-0045 59.227 µM -0.534466696261818 0.306056917817751 no 2353 0.296509342546171 3460 88733 SGTC_8 0354-0001 70 µM -0.536453701617866 0.305335700566261 no 2354 0.295822512775356 3432 4993152 SGTC_1442 4112-3290 3 µM -0.536807477260181 0.305207370803582 no 2355 0.295700303102229 3374 704353 SGTC_2697 mebhydrolin 72.4 µM -0.537274370314093 0.305038045102373 no 2356 0.295539053222751 3460 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3227 9130768 49.47 µM -0.537678049460042 0.30489167849981 no 2357 0.295399667999097 3409 17720899 SGTC_1456 k015-0012 13 µM -0.537777181424861 0.304855739853292 no 2358 0.29536544363083 3498 2989616 SGTC_2502 avocadyne acetate 18.59 µM -0.538014332192795 0.304769772422699 no 2359 0.295283576986642 3366 3952079 SGTC_2343 7990716 14.84 µM -0.538102356957072 0.304737866085266 no 2360 0.295253192679502 3353 6456862 SGTC_2305 7443522 69.23 µM -0.539439421709555 0.304253402925103 no 2361 0.294791842951047 3396 5415886 SGTC_2275 7947463 200 µM -0.541124618602033 0.303643289026714 no 2362 0.294210845285733 3416 1225414 SGTC_3122 9126309 49.47 µM -0.541594985563847 0.303473093461802 no 2363 0.294048773492932 3451 17591206 SGTC_2917 7979103 53.79 µM -0.541687253230754 0.303439712724762 no 2364 0.294016986165841 3449 2980565 SGTC_2534 helenine 20.12 µM -0.543287866238924 0.302860901770475 no 2365 0.293465808621003 3403 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_647 0140-0236 81 µM -0.543646481332695 0.302731287802169 no 2366 0.29334238372647 3398 990837 SGTC_2905 7799065 20.05 µM -0.545520457773663 0.302054382546368 no 2367 0.292697807119851 3434 1296806 SGTC_1928 4'-methoxychalcone 40.3 µM -0.545690894897866 0.301992852119276 no 2368 0.29263921588294 3505 641818 SGTC_2428 5615643 7.78 µM -0.546071166105562 0.301855588653649 no 2369 0.292508509544513 3417 2253075 SGTC_1401 3807-4679 7.6 µM -0.546207001000441 0.301806564211918 no 2370 0.292461827124114 3429 3291456 SGTC_229 benomyl 22.8748 µM -0.547067563866341 0.301496059950675 no 2371 0.292166157718783 3431 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1901 st060216 58.6 µM -0.547656887126308 0.30128350605685 no 2372 0.291963760212767 3411 688792 SGTC_2366 9070441 60.58 µM -0.547868673713883 0.30120713651441 no 2373 0.29189104006085 3359 6837235 SGTC_1446 4239-0190 62 µM -0.548487980701734 0.300983866514474 no 2374 0.291678439988173 3331 1340085 SGTC_2818 7996756 12.99 µM -0.548638546025485 0.300929596602279 no 2375 0.291626763770257 3361 2241621 SGTC_2457 5731572 11.68 µM -0.549562854745104 0.300596534600123 no 2376 0.29130962108611 3453 2865357 SGTC_2824 7998404 51.95 µM -0.550131073832731 0.300391867264972 no 2377 0.291114737443218 3367 837851 SGTC_108 0509-0257 621.132 µM -0.550787022083948 0.300155679011178 no 2378 0.290889840836015 3386 536624 SGTC_3134 9127454 49.47 µM -0.551519562582153 0.299892011380591 no 2379 0.290638780045669 3518 24262820 SGTC_2272 7805186 180 µM -0.553101725913321 0.299322892050788 no 2380 0.290096877458453 3452 2956062 YPR165W RHO1 SGTC_3118 9124250 49.47 µM -0.553414661010643 0.299210384349956 no 2381 0.289989751003153 3356 1504786 SGTC_283 0987-0079 11.7 µM -0.553581072400608 0.299150563265822 no 2382 0.289932791274851 3474 411556 SGTC_2446 5162541 200 µM -0.55388747343445 0.299040433311503 no 2383 0.289827929248259 3387 1549321 SGTC_903 1134-0042 114 µM -0.554497878788009 0.298821089742155 no 2384 0.289619078485021 3387 701009 SGTC_1604 st002052 72.4 µM -0.555040005489472 0.298626342803556 no 2385 0.289433648585699 3496 6254834 YHR062C RPP1 SGTC_130 0136-0219 337.655 µM -0.556863513084831 0.29797171229623 no 2386 0.288810342712046 3413 234244 SGTC_2404 5161160 200 µM -0.559508175603513 0.29702345521546 no 2387 0.287907476582428 3421 2831543 SGTC_1530 rhein 70.4 µM -0.560282526036379 0.296746069417926 no 2388 0.28764337215735 3465 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_980 1473-0395 201 µM -0.560671932572842 0.29660662205373 no 2389 0.287510602201024 3405 768876 SGTC_415 dibenzyl ketone 100 µM -0.560743480024757 0.29658100401343 no 2390 0.287486210918535 3415 7593 SGTC_1072 oxiconazole 14.9 nM -0.561269766856166 0.296392594676726 no 2391 0.287306824253835 3474 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_31 0508-1974 57.237 µM -0.561521690676751 0.29630242601726 no 2392 0.287220973907168 3450 6810525 SGTC_773 4358-1457 44.6 µM -0.561794819496123 0.29620468187159 no 2393 0.28712791106226 3480 1186886 SGTC_1730 st033808 45.1 µM -0.563039315817375 0.295759503445258 no 2394 0.286704056192016 3338 1045166 SGTC_1761 st044296 37 µM -0.563548500840773 0.295577447584735 no 2395 0.286530721753304 3428 1826700 SGTC_377 3970-0964 33.1 µM -0.56437311960325 0.29528271973741 no 2396 0.286250114301728 3463 16481235 SGTC_1391 3442-0225 151 µM -0.565185627040438 0.294992452970971 no 2397 0.285973755882005 3408 5227075 SGTC_1678 st019265 80.2 µM -0.565790610282797 0.294776409254671 no 2398 0.285768065135694 3524 5367020 SGTC_1280 0880-0253 10.1 µM -0.566259937144194 0.294608859638935 no 2399 0.285608545246174 3409 6836607 SGTC_2720 fluspirilene 36.88 µM -0.566864298070495 0.294393167622219 no 2400 0.285403190958611 3442 3396 An atypical antipsychotic. SGTC_3252 9135871 49.47 µM -0.567353289959903 0.294218703352986 no 2401 0.28523708910583 3488 17682838 SGTC_2941 9056145 11.23 µM -0.567417924464943 0.294195646398327 no 2402 0.285215137360396 3438 2119517 SGTC_307 1501-1223 22.3 µM -0.568387253994092 0.293849959344384 no 2403 0.284886021650651 3457 2830329 SGTC_681 1642-0006 26.6 µM -0.568644296295769 0.2937583231857 no 2404 0.28479877867575 3489 4446530 SGTC_2592 piperlongumine 83.33 µM -0.568840297999825 0.293688457024329 no 2405 0.284732262117109 3400 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_633 0437-0093 97.7 µM -0.570174341756265 0.293213132356616 no 2406 0.284279728455865 3454 2831118 SGTC_2040 5100729 123 µM -0.570451218049955 0.29311452503171 no 2407 0.28418584971634 3416 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2653 dihydrofissinolide 100 µM -0.571457725524469 0.29275619491095 no 2408 0.283844704375751 3474 6857746 SGTC_3147 9097027 49.47 µM -0.571671869545171 0.292679983026972 no 2409 0.283772147765428 3411 25236841 SGTC_34 0469-0683 81.75 µM -0.573103559190687 0.292170694789911 no 2410 0.283287288750586 3448 3690923 SGTC_1630 st005209 31.3 µM -0.573208119159967 0.292133516325995 no 2411 0.283251893826091 3505 3367314 SGTC_339 3091-4833 71.4 µM -0.573310611560977 0.292097075165728 no 2412 0.283217200859453 3464 3240077 SGTC_650 1328-0195 38 µM -0.573813229781441 0.29191839995608 no 2413 0.28304709759371 3475 2780821 SGTC_3186 9110464 49.47 µM -0.573865700751821 0.291899750042011 no 2414 0.283029342442687 3508 17018021 SGTC_495 decylubiquinone 155 µM -0.573918652881696 0.291880929670597 no 2415 0.283011425018692 3445 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1043 0916-0009 19.3 µM -0.575118190990199 0.291454738501034 no 2416 0.282605682986018 3519 3101130 SGTC_1906 st060206 94.7 µM -0.576327253199283 0.291025457440598 no 2417 0.282197002597663 3479 5133468 SGTC_566 0958-0068 16.5 µM -0.576596704747274 0.290929828148256 no 2418 0.282105962881966 3497 6815365 SGTC_221 trifluoperazine 10.304 µM -0.577270354130614 0.29069081190908 no 2419 0.281878418551571 3490 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2511 berberine 10.47 µM -0.577860729717341 0.290481417429814 no 2420 0.281679075064684 3451 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.578262192612327 0.29033906686383 no 2421 0.281543557799705 3451 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_673 1082-0474 110 µM -0.578414103968696 0.290285210711224 no 2422 0.281492287013093 3462 3098046 SGTC_1683 st010134 710 nM -0.57861481508075 0.290214061072089 no 2423 0.281424552990945 3464 3818134 SGTC_1128 3448-9350 235 µM -0.58512568221348 0.287910481826689 no 2424 0.279231605658699 3419 619386 SGTC_1116 jasmonic acid  1.58368 µM -0.585503239922268 0.287777165189436 no 2425 0.279104694363211 3532 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_961 1252-1571 372 µM -0.587313430908386 0.287138387347176 no 2426 0.278496611205494 3529 6813498 SGTC_1963 st076565 50.3 µM -0.588345578825466 0.286774465085264 no 2427 0.278150179070576 3501 4914280 SGTC_2482 5981709 142.65 µM -0.588574591748258 0.286693747681109 no 2428 0.278073341227841 3443 877755 SGTC_231 b-estradiol 524 µM -0.588782935823795 0.28662032453376 no 2429 0.278003447141464 3419 450 A steroid. SGTC_1232 0279-0259 161 µM -0.589007829753196 0.28654107901408 no 2430 0.277928010626159 3478 1560000 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.590053920510003 0.286172606346198 no 2431 0.277577250174303 3466 15053 SGTC_2004 4023728 41.89 µM -0.590354341739602 0.28606682825794 no 2432 0.277476557143014 3516 360084 YDR527W RBA50 SGTC_512 prima-1 270 µM -0.590947174611101 0.285858146770715 no 2433 0.277277908068796 3528 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2329 6138490 200 µM -0.592566015940461 0.285288671832881 no 2434 0.276735814075727 3489 720019 SGTC_943 3253-1379 105 µM -0.592747190381991 0.285224972050505 no 2435 0.276675177342168 3521 668464 SGTC_1425 4048-4433 7.33 µM -0.593385020964454 0.285000768816445 no 2436 0.276461755549193 3563 23734946 SGTC_460 trequinsin 123 µM -0.593846705265709 0.284838535046983 no 2437 0.276307323700311 3532 5537 A vasodilator. SGTC_324 1315-0088 19.6 µM -0.595233847412271 0.284351364837617 no 2438 0.275843584073859 3479 6787421 SGTC_2930 9013230 14.89 µM -0.597282852546065 0.283632474903056 no 2439 0.27515927546539 3510 2995857 SGTC_2536 dehydroabietamide 32.04 µM -0.59766671357831 0.283497894813073 no 2440 0.275031169984176 3537 3983547 SGTC_3288 9119690 36.221 µM -0.601024979222828 0.282321807719136 no 2441 0.273911674517796 3467 17595618 YKL019W RAM2 SGTC_2580 diallyl disulphide 81.36 µM -0.603829148291725 0.281341570826963 no 2442 0.272978619081404 3484 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1514 1189-1591 158 µM -0.6044688518746 0.281118183749154 no 2443 0.272765985934434 3557 767698 YMR146C TIF34 SGTC_2125 5246583 200 µM -0.605063867300844 0.280910478894067 no 2444 0.272568280619379 3588 835267 SGTC_2104 5389443 200 µM -0.60525368335852 0.280844234512907 no 2445 0.272505225555157 3571 2244536 SGTC_1741 st038134 10.228 µM -0.605858953548567 0.280633050207283 no 2446 0.272304209017179 3602 1272587 SGTC_397 arbidol 50 µM -0.606542972102047 0.280394482389048 no 2447 0.27207712803739 3562 131410 A RNA synthesis inhibitor. SGTC_1721 st082152 9.2685 µM -0.607742115812094 0.279976489477867 no 2448 0.271679262779191 3510 5296051 SGTC_1476 4112-3294 3.34 µM -0.60965078045571 0.279311798263113 no 2449 0.271046582741088 3568 704369 SGTC_810 3825-7150 143 µM -0.610410401983573 0.279047474029836 no 2450 0.27079498963852 3576 22330411 YGL099W LSG1 SGTC_634 1611-4317 11.2 µM -0.611313215242587 0.278733481896495 no 2451 0.270496121908118 3565 2843522 SGTC_159 3970-0959 50 µM -0.611463914952494 0.278681086347636 no 2452 0.270446250260458 3636 6615653 SGTC_2075 5212009 200 µM -0.61415286850256 0.27774699311002 no 2453 0.269557157477152 3498 780898 SGTC_220 paclitaxel 373.376 µM -0.614406705108024 0.277658893963085 no 2454 0.269473303039436 3526 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2962 9082311 13.18 µM -0.615985193440852 0.277111354122784 no 2455 0.268952146064969 3494 16459453 SGTC_1331 1472-0049 76.2 µM -0.616231751056299 0.277025876919223 no 2456 0.268870787806955 3501 24051409 SGTC_3284 9108171 64.8615 µM -0.616824562505608 0.27682041241437 no 2457 0.268675224458216 3492 8687505 SGTC_1050 3232-1156 69.3 µM -0.61707675614439 0.276733026413567 no 2458 0.268592049642404 3469 700529 SGTC_610 4215-0184 155 µM -0.619783096979741 0.275796121254538 no 2459 0.267700299264949 3564 5605015 SGTC_1967 st070177 51.4 µM -0.621119207169352 0.275334150164112 no 2460 0.267260596293994 3588 5729214 SGTC_1690 st023502 41.2 µM -0.622547347289656 0.27484078041152 no 2461 0.266791010336997 3559 24207482 SGTC_1297 1068-0111 14.1 µM -0.622627545425041 0.274813087840309 no 2462 0.266764652802653 3513 767057 SGTC_140 0062-0056 502.533 µM -0.623065600914289 0.274661850712138 no 2463 0.266620706817633 3529 3758964 SGTC_679 0422-0091 41.4 µM -0.624018201962112 0.274333110278938 no 2464 0.266307815663217 3578 627384 YHR062C RPP1 SGTC_2647 atorvastatin 60.16 µM -0.624443682257056 0.274186340790058 no 2465 0.266168122550541 3542 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2575 plumbagin 510 nM -0.624480263700496 0.274173723826718 no 2466 0.26615611391294 3523 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3310 9130229 44.1445 µM -0.62464142446541 0.274118142790261 no 2467 0.266103212727443 3544 7761258 SGTC_320 4092-0846 5.34 µM -0.625738772062011 0.273739838206546 no 2468 0.265743148877056 3511 1359356 SGTC_3022 9087993 49.47 µM -0.626462490184119 0.273490481736182 no 2469 0.265505816300077 3575 17173644 SGTC_2904 7225135 42.03 µM -0.626572214120547 0.273452686264148 no 2470 0.265469843359231 3621 4446116 SGTC_2120 5538279 151.968 µM -0.626880263687132 0.273346589431559 no 2471 0.265368862672747 3555 2058197 SGTC_1362 1611-0397 101 µM -0.627028561142167 0.273295520862115 no 2472 0.265320256738043 3552 27816 SGTC_125 0133-0007 11.75 µM -0.627097921561054 0.273271637129182 no 2473 0.265297524736664 3622 26541 SGTC_1733 st037357 54.9 µM -0.628440951011473 0.272809379080775 no 2474 0.264857558797113 3540 1272339 YGL099W LSG1 SGTC_376 3970-0862 59.1 µM -0.628541154557117 0.272774905523286 no 2475 0.264824747773703 3553 3135186 SGTC_1781 st038725 66.3 µM -0.62902405713844 0.272608800296612 no 2476 0.264666653327291 3551 4270275 YIL048W NEO1 SGTC_2028 5153890 36.43 µM -0.63031647697759 0.272164490515712 no 2477 0.26424377238182 3549 2830968 YPR165W RHO1 SGTC_1760 st045453 10.4495 µM -0.630325492794018 0.27216139231127 no 2478 0.264240823607467 3575 3323419 YIL048W NEO1 SGTC_541 4513-1321 94 µM -0.630629778202781 0.272056837641527 no 2479 0.264141311776068 3489 747515 SGTC_1323 1348-1351 11.2 µM -0.630800963176708 0.271998026024636 no 2480 0.264085336772996 3506 6989654 SGTC_3000 9075062 71.4286 µM -0.630892311925882 0.271966645205452 no 2481 0.264055469530336 3521 17057871 SGTC_3191 9110352 49.47 µM -0.631468693624349 0.271768683702953 no 2482 0.263867056380507 3558 17122424 SGTC_2858 9025781 8.96 µM -0.633496444120609 0.27107281194287 no 2483 0.263204751104447 3613 4894980 YPL153C RAD53 SGTC_1390 3413-2614 145 µM -0.63632832227144 0.270102473799224 no 2484 0.262281224296154 3582 3421432 SGTC_1413 3910-0535 34.4 µM -0.636784858525091 0.269946205240758 no 2485 0.262132495062549 3577 2876951 SGTC_1747 st037496 66.6 µM -0.636947827589711 0.269890433248237 no 2486 0.262079413879786 3565 723305 SGTC_2182 6325192 200 µM -0.637060638713683 0.269851829906171 no 2487 0.26204267302957 3542 736248 SGTC_2110 5483698 200 µM -0.637905453347107 0.269562826909075 no 2488 0.261767613824209 3564 2848765 YHR062C RPP1 SGTC_349 k015-0014 24 µM -0.638469117541535 0.269370089083189 no 2489 0.261584175477184 3548 2196908 SGTC_2612 dictamnine 15.46 µM -0.638637620900717 0.269312484913608 no 2490 0.261529350715425 3518 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1740 st038286 13.222 µM -0.638883420217592 0.269228467605677 no 2491 0.261449387287283 3590 716786 SGTC_2589 lobaric acid 100 µM -0.639334525729985 0.269074308263367 no 2492 0.26130266632218 3534 73157 A novel microtubule depolymerizer. SGTC_79 0052-0007 94.094 µM -0.639461995686544 0.269030755120327 no 2493 0.261261214696524 3627 2801472 SGTC_3169 9102970 49.47 µM -0.641035137616135 0.268493545211763 no 2494 0.260749927009551 3638 17027839 SGTC_2520 obtusaquinone 4.71 µM -0.641981292103369 0.268170704235881 no 2495 0.260442664976485 3647 5967872 SGTC_1121 fusaric acid 630.51 nM -0.642632022396766 0.267948779509341 no 2496 0.260231449717973 3566 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2101 5377231 179.231 µM -0.644818838630842 0.267203667074209 no 2497 0.259522296132444 3584 2844213 SGTC_871 0574-0004 149 µM -0.644915578205951 0.267170729234137 no 2498 0.259490947921959 3541 9551173 SGTC_1209 2323-2347 50.3 µM -0.646176134418334 0.266741723141281 no 2499 0.259082646760552 3571 5412760 SGTC_188 3229-0966 278.469 µM -0.646738665933181 0.266550388764289 no 2500 0.258900546934245 3663 5722370 SGTC_1247 0448-0043 5.84 µM -0.647507654402004 0.266288944327413 no 2501 0.25865172108911 3602 3089013 YGL099W LSG1 SGTC_104 0074-0074 590.992 µM -0.6476858078565 0.266228393372472 no 2502 0.258594092661218 3472 3943124 SGTC_128 0906-2981 13.371 µM -0.64904926631477 0.265765210805658 no 2503 0.258153266359076 3580 6740226 SGTC_1211 1056-0033 32.3 µM -0.649384475929689 0.265651398825331 no 2504 0.258044947828495 3604 6741922 SGTC_2624 nerol 100 µM -0.650179607408344 0.265381530842852 no 2505 0.257788105963638 3560 637566 A natural product oil. SGTC_696 1560-0013 611 µM -0.650240600753278 0.265360835421258 no 2506 0.257768409489622 3657 1650269 SGTC_2755 lomerizine 42.69 µM -0.651719632215751 0.264859241727493 no 2507 0.257291027687942 3602 3949 A calcium channel blocker. SGTC_286 k060-0067 22.9 µM -0.652653200223089 0.264542882944767 no 2508 0.2569899399539 3565 5985051 SGTC_2412 st077135 33.4 µM -0.654068242253173 0.264063733583556 no 2509 0.2565339203426 3675 13258915 SGTC_2882 9058044 58.44 µM -0.654227138530808 0.264009957120407 no 2510 0.256482739847048 3565 18076804 SGTC_2072 5231554 129 µM -0.654429046163452 0.263941632052988 no 2511 0.256417713068138 3669 789545 SGTC_1424 4048-1941 275 µM -0.655190230223215 0.263684130221193 no 2512 0.256172641859421 3653 X1424 SGTC_553 k007-0256 45.7 µM -0.65585147735119 0.263460540229156 no 2513 0.255959845574047 3630 6287000 SGTC_1471 k673-0312 37 µM -0.657026304166563 0.263063530443566 no 2514 0.255582001559712 3606 24099884 SGTC_740 k014-0057 261 µM -0.658252380823006 0.262649528050141 no 2515 0.255187985637953 3597 4012779 SGTC_3067 9117431 49.47 µM -0.658932094144277 0.262420156807785 no 2516 0.254969687723229 3596 17150885 SGTC_1523 st012844 44.7 µM -0.6611492998969 0.261672667849914 no 2517 0.254258285843061 3617 4274103 SGTC_2449 5812982 45.77 µM -0.661407039703384 0.261585846692454 no 2518 0.254175656271113 3587 776185 SGTC_401 neomycin 50 µM -0.664657928852052 0.260492036531694 no 2519 0.253134654255814 3581 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_678 1218-2179 85.9 µM -0.665652408337721 0.260157900129369 no 2520 0.252816649857149 3610 6820081 YOR116C RPO31 SGTC_463 ikarugamyin 104 µM -0.666347136625608 0.259924608647459 no 2521 0.2525946216521 3659 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_228 caffeine 993.056 µM -0.668192857015712 0.259305335731171 no 2522 0.252005247214397 3619 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2309 7664088 163.95 µM -0.66913823109646 0.258988440966444 no 2523 0.251703652128333 3639 704922 SGTC_163 TUB2.036 7.546 µM -0.671605456233775 0.258162357581771 no 2524 0.250917451906872 3649 15992207 YJR013W GPI14 SGTC_3209 9113616 49.47 µM -0.672057799262498 0.258011051119024 no 2525 0.250773450452519 3650 16649353 SGTC_2192 5915882 198.485 µM -0.672070714686244 0.258006731650389 no 2526 0.250769339525642 3589 2876149 SGTC_594 1487-1584 10.8 µM -0.672376225399202 0.257904566774297 no 2527 0.250672107113631 3607 5013332 SGTC_1680 diphenhydramine 100 µM -0.673139644140146 0.257649366102315 no 2528 0.250429227349415 3643 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_608 k048-0125 159 µM -0.673614423140676 0.257490719987906 no 2529 0.250278240524518 3653 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2674 ligustilide 100 µM -0.67410497869911 0.257326855496887 no 2530 0.250122287232133 3605 5319022 A signalling regulator. SGTC_1485 3909-9022 254 µM -0.675315210843906 0.256922823152633 no 2531 0.249737760983728 3657 714516 SGTC_1931 st074438 57.1 µM -0.676291871215623 0.25659700887151 no 2532 0.249427676372355 3608 2787313 SGTC_3196 9111891 49.47 µM -0.676816694830116 0.256422016436174 no 2533 0.249261132154747 3645 18891510 SGTC_2188 6126565 140.678 µM -0.677294924793968 0.256262613931266 no 2534 0.249109425175901 3598 874518 SGTC_3167 9103034 49.47 µM -0.677384039476168 0.256232916142444 no 2535 0.249081161111633 3644 5127859 SGTC_2053 5265679 138 µM -0.677831839657749 0.256083712285015 no 2536 0.248939160365499 3626 764595 SGTC_1739 st037196 92.5 µM -0.679120471999186 0.255654602056481 no 2537 0.248530766029698 3654 612214 SGTC_2108 5365811 200 µM -0.680693439059702 0.255131318693271 no 2538 0.248032744335082 3666 780283 SGTC_870 0573-2213 57.6 µM -0.680714702849582 0.255124248648111 no 2539 0.248026015593963 3646 3916321 SGTC_3005 9076496 71.4286 µM -0.68093073801821 0.25505242444005 no 2540 0.247957658667952 3654 21368410 SGTC_3070 9117005 49.47 µM -0.681119023017759 0.254989834829614 no 2541 0.24789809053244 3673 8779016 SGTC_2945 9067681 61.76 µM -0.681134799261386 0.254984590863083 no 2542 0.247893099714696 3724 16456930 SGTC_245 methotrexate 289.6 µM -0.681222138679952 0.254955560576005 no 2543 0.247865470842936 3637 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1347 1493-0251 600 nM -0.682652598783441 0.254480343745225 no 2544 0.247413194416442 3671 3986378 SGTC_1199 1638-0010 4.46 µM -0.682838555900521 0.254418600559659 no 2545 0.247354431745926 3634 3111136 SGTC_107 0358-0022 2.6945 µM -0.682968242682676 0.25437554541337 no 2546 0.247313454984347 3636 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1933 st074711 15.9 µM -0.682993235304494 0.254367248468618 no 2547 0.247305558554211 3642 17250958 SGTC_807 1315-0151 48 µM -0.683258077140633 0.254279336113681 no 2548 0.247221889939199 3683 4011080 SGTC_1669 st015249 58.4 µM -0.683390010661938 0.254235547669024 no 2549 0.247180215258739 3715 722793 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.685861921663181 0.253415857439137 no 2550 0.246400092110207 3685 6708784 An antioxidant flavonoid SGTC_1826 st055655 41.6 µM -0.689064456666683 0.252355959969021 no 2551 0.245391353037563 3687 676168 SGTC_1312 1218-2183 165 µM -0.689458566844312 0.25222568859643 no 2552 0.245267369194843 3673 6744073 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.689505983454802 0.25221001763628 no 2553 0.245252454586439 3674 2724 A muscle relaxant with antifungal properties. SGTC_2912 7964298 10.93 µM -0.689680365178097 0.252152389737922 no 2554 0.24519760806301 3699 2975850 SGTC_2067 5224629 34.075 µM -0.690180783272766 0.251987055224691 no 2555 0.245040253235825 3644 2835000 SGTC_2693 st077581 40.7 µM -0.690274592936685 0.251956067559702 no 2556 0.245010761142238 3685 25238761 SGTC_3109 9122853 49.47 µM -0.690642532427388 0.251834547410123 no 2557 0.244895105931048 3697 1234709 SGTC_355 1311-2252 105 µM -0.692764268245783 0.251134401347222 no 2558 0.244228749714752 3654 5338538 SGTC_366 0181-0206 4.31 µM -0.694088939187617 0.250697799292536 no 2559 0.243813217325696 3675 274874 SGTC_3283 9109332 35.8195 µM -0.695464732601843 0.250244773548984 no 2560 0.243382052746128 3566 17027281 SGTC_2821 7996764 71.43 µM -0.695705952591924 0.250165388595871 no 2561 0.243306498467501 3725 2987135 SGTC_2092 5303694 80.6725 µM -0.696069197377393 0.250045870764252 no 2562 0.243192747831096 3665 1963699 SGTC_9 0092-0002 10.449 µM -0.696802374266417 0.249804727099574 no 2563 0.242963240023685 3651 759368 SGTC_2242 6630449 61.2675 µM -0.698726714228534 0.249172394775354 no 2564 0.242361417843981 3692 691249 YDR170C SEC7 SGTC_467 ro 31-8220 72.8 µM -0.699236048645417 0.249005171611722 no 2565 0.242202262809958 3628 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2826 7992541 19.48 µM -0.699391145489828 0.248954262539345 no 2566 0.242153809946532 3726 2985066 SGTC_1821 st053465 65.6 µM -0.700110524085231 0.248718205765178 no 2567 0.24192914197779 3639 675086 SGTC_360 0957-0399 1.01 µM -0.7006140899553 0.248553036691073 no 2568 0.241771941438776 3684 6752301 YPR165W RHO1 SGTC_209 4077-0173 175.592 µM -0.700957952784648 0.248440283631267 no 2569 0.24166462801291 3604 15993494 SGTC_3078 9116413 49.47 µM -0.701320728886757 0.248321358441022 no 2570 0.241551440129646 3624 17177322 SGTC_2318 6029776 164 µM -0.701688773388097 0.248200737185413 no 2571 0.24143663790474 3677 818325 SGTC_2017 5132927 60.65 µM -0.703035896961743 0.247759503562843 no 2572 0.241016689475737 3679 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1831 st055328 12 µM -0.703478364106255 0.247614670362065 no 2573 0.240878842750825 3679 1103068 SGTC_2600 tangeritin 87.95 µM -0.704100054793049 0.247411248181034 no 2574 0.24068523300493 3652 68077 A bioactive flavone. SGTC_1041 0206-0046 107 µM -0.70421720255972 0.24737292649505 no 2575 0.240648759799972 3706 50494 SGTC_338 4055-0136 114 µM -0.706253721165242 0.246707242446135 no 2576 0.240015183829319 3648 2900563 SGTC_1156 4092-0367 4.88 µM -0.706305395341103 0.246690364012995 no 2577 0.239999119452245 3705 1357585 SGTC_2281 7943571 200 µM -0.706615326526145 0.246589143586087 no 2578 0.23990278089426 3759 1244024 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.707700677322417 0.246234854301171 no 2579 0.239565578356975 3754 6710655 SGTC_288 1315-0019 35.1 µM -0.708804439995153 0.24587483496137 no 2580 0.239222921053853 3746 6811474 SGTC_1123 mangostin 811.285 nM -0.709315183846322 0.245708338953681 no 2581 0.239064453993953 3678 5281650 An antioxidant. SGTC_115 0527-0192 112.043 µM -0.709544541610308 0.245633590937734 no 2582 0.238993310479072 3735 4233931 SGTC_2320 7373003 200 µM -0.709683891079446 0.245588182715583 no 2583 0.238950091909991 3709 5415828 SGTC_1478 0453-0656 35.7 µM -0.70982604189689 0.24554186629608 no 2584 0.238906008919768 3712 5258496 SGTC_25 0118-0223 35.662 µM -0.710649672414288 0.245273598516605 no 2585 0.238650676941491 3714 5333628 SGTC_1235 benzylparaben 21.5 µM -0.712458110768261 0.244685118513966 no 2586 0.238090571030181 3673 7180 SGTC_2355 9061122 103.12 µM -0.712496510935246 0.24467263104724 no 2587 0.238078685623531 3700 5302957 SGTC_247 mechlorethamine 29.705 µM -0.712530528705248 0.244661568992136 no 2588 0.238068156903713 3626 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1250 0485-0349 40.2 µM -0.712785432510924 0.244578686769342 no 2589 0.23798927064845 3701 6842794 YDL195W SEC31 SGTC_742 0kpi-0133 140 µM -0.713319091650804 0.244405215959066 no 2590 0.237824163108801 3708 2728852 SGTC_452 diindolylmethane 8 µM -0.713551160457049 0.244329800549459 no 2591 0.237752383493054 3654 3071 Inhibits expression of several cancer promoting factors. SGTC_1578 josamycin 24.2 µM -0.714008508719698 0.244181212787802 no 2592 0.237610959022192 3661 5282165 A P450 substrate. SGTC_344 k064-0035 6.43 µM -0.714599069059393 0.243989417887495 no 2593 0.237428410078304 3675 5088750 SGTC_82 0054-0107 293.755 µM -0.714633037025893 0.243978388662682 no 2594 0.237417912534211 3695 3104697 SGTC_1173 0443-0020 122 µM -0.714758921504055 0.243937516962661 no 2595 0.23737901110691 3705 5331295 SGTC_2456 5770359 74.46 µM -0.715050185306397 0.243842964687932 no 2596 0.237289016783187 3693 3118787 SGTC_1436 4092-1007 8.32 µM -0.715084813454203 0.243831724750442 no 2597 0.237278318668011 3679 2881121 SGTC_1023 4482-3888 16 µM -0.716844887429956 0.243260791474386 no 2598 0.236734905630502 3696 3303168 SGTC_2018 5133068 143 µM -0.717864534967943 0.242930368791777 no 2599 0.236420408531953 3705 785362 SGTC_1608 st001473 40.5 µM -0.718168603182182 0.242831880750652 no 2600 0.236326667159507 3670 7292267 SGTC_1716 st033144 30.6155 µM -0.718491680009153 0.242727259478981 no 2601 0.236227088038132 3711 674617 SGTC_927 2425-1185 123 µM -0.718499440105445 0.242724746843851 no 2602 0.236224696496303 3685 730375 SGTC_351 caspofungin 25 nM -0.719207911062863 0.242495410952266 no 2603 0.236006412877722 3744 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2372 9071633 200 µM -0.719894267928704 0.242273345489848 no 2604 0.235795048769602 3742 21321366 SGTC_1450 4112-4260 37.6 µM -0.721428644722555 0.241777308581345 no 2605 0.235322913972251 3688 1633175 SGTC_2277 7947813 106.88 µM -0.722101562276172 0.241559940213834 no 2606 0.235116018884607 3762 1246798 SGTC_54 0159-0055 9 µM -0.722409570829863 0.241460481542248 no 2607 0.235021352168902 3736 3319099 SGTC_2854 9024559 71.43 µM -0.723265276403035 0.241184283457948 no 2608 0.234758460815435 3711 3163529 SGTC_898 1000-0849 28.3 µM -0.723803395560068 0.24101068147406 no 2609 0.234593222212044 3668 6751807 SGTC_1138 3761-0006 1.03 µM -0.72422725944895 0.240873987103988 no 2610 0.234463112926816 3672 12061087 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.724928166306407 0.240648040076885 no 2611 0.234248050136532 3731 165506 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.727942008152564 0.239677802347414 no 2612 0.233324543279366 3761 5379071 SGTC_3037 9091026 49.47 µM -0.728880602292459 0.239376079873709 no 2613 0.23303735067252 3730 25236398 YIL048W NEO1 SGTC_1432 4049-0298 68.4 µM -0.730055198928831 0.238998783976906 no 2614 0.232678222335143 3724 741646 SGTC_2931 9014674 55.67 µM -0.730553078992541 0.238838956517193 no 2615 0.232526090328853 3738 2996810 SGTC_2132 5317594 122.667 µM -0.731054345925886 0.238678100894624 no 2616 0.23237297932264 3705 794577 SGTC_1776 st049249 45.9 µM -0.731183121243896 0.238636786708357 no 2617 0.232333654209337 3757 1822314 SGTC_1438 4092-1045 4 µM -0.731769008500246 0.238448869552087 no 2618 0.232154784042244 3713 1351342 SGTC_1092 toremifene 6.32 µM -0.732067215800818 0.238353253829693 no 2619 0.232063771412272 3717 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3135 9127742 49.47 µM -0.733254452162654 0.237972792494123 no 2620 0.231701624852572 3784 3643468 SGTC_46 0329-0187a 2.197 µM -0.733898807816654 0.23776644197631 no 2621 0.231505206869703 3773 46494817 SGTC_3025 9087895 49.47 µM -0.733914449091608 0.237761434184751 no 2622 0.231500440117239 3747 17173641 SGTC_63 0099-0242 26.702 µM -0.734066859092431 0.237712640838446 no 2623 0.231453995313577 3773 3898502 YLR359W ADE13 SGTC_557 1315-0110 16.2 µM -0.734824533501225 0.237470156485619 no 2624 0.231223181826558 3732 6833801 SGTC_150 3970-0969 77.2 µM -0.735767339334948 0.237168612798171 no 2625 0.2309361503881 3820 6615640 SGTC_907 3448-6986 75.5 µM -0.736307970931704 0.23699579404107 no 2626 0.230771648207502 3757 590582 SGTC_853 0419-0306 21 µM -0.736419232094556 0.23696023679255 no 2627 0.230737802030757 3733 762713 SGTC_1726 st035556 14.5795 µM -0.737308827584204 0.236676042100709 no 2628 0.230467282579053 3856 5919439 SGTC_3236 9132701 49.47 µM -0.73827055343065 0.236369015309383 no 2629 0.230175028352409 3752 24282524 SGTC_920 mycophenolic acid 780.421 nM -0.738608906500087 0.236261049728754 no 2630 0.230072257191101 3765 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1944 st076371 56.9 µM -0.739162677469715 0.236084404742919 no 2631 0.229904110536403 3749 24208455 SGTC_1484 3473-2379 286 µM -0.739508336661628 0.235974181319714 no 2632 0.229799189685635 3844 671917 SGTC_1692 fluoroquinolonic acid 71 µM -0.740824272794223 0.235554816666706 no 2633 0.229399997913201 3761 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1126 isoteolin 1.0172 µM -0.741191986264686 0.235437706685503 no 2634 0.229288520838437 3717 133323 SGTC_1127 asiatic acid 681.4 nM -0.742187729274408 0.235120742212379 no 2635 0.228986801051878 3728 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2719 novobiocin 32.65 µM -0.742687222150308 0.234961832672259 no 2636 0.228835533808687 3725 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_743 1275-0778 158 µM -0.746688065759584 0.233691140973096 no 2637 0.227625937629881 3763 2849257 YMR203W TOM40 SGTC_3295 9122362 53.5725 µM -0.747154696947649 0.233543184616237 no 2638 0.227485093349405 3772 4730473 SGTC_2245 6637752 200 µM -0.747241967387869 0.233515519245068 no 2639 0.227458757776733 3788 681890 SGTC_777 1315-0167 517 µM -0.747292714945041 0.233499432732161 no 2640 0.22744344449239 3788 4221767 SGTC_2892 9047358 58.44 µM -0.747487066598872 0.233437830714892 no 2641 0.227384803451467 3748 6466771 SGTC_256 clotrimazole 625 nM -0.748981587720218 0.23296442620415 no 2642 0.226934151535749 3715 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_775 4577-0580 57.3 µM -0.750317988618129 0.232541559833464 no 2643 0.226531605520422 3811 2006902 SGTC_3320 9137005 35.139 µM -0.752076729723646 0.231985706808056 no 2644 0.226002458547136 3791 4908713 SGTC_1219 1469-0211 33.1 µM -0.752577400301386 0.231827604435684 no 2645 0.225851951213535 3735 6822282 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.75447501508301 0.231228918478741 no 2646 0.225282021224219 3763 688798 SGTC_2216 7189485 200 µM -0.754630353882289 0.231179948252938 no 2647 0.225235402833082 3752 731273 SGTC_2598 perillyl alcohol 100 µM -0.755550346138075 0.230890041304984 no 2648 0.224959417979556 3780 10819 An apoptosis inducer. SGTC_1381 2324-0066 62.1 µM -0.758994943570839 0.229806388449123 no 2649 0.223927790772089 3798 10885928 SGTC_637 1181-0519 7.26 µM -0.75971021512433 0.229581725247112 no 2650 0.223713910677235 3781 6252091 YGR060W ERG25 SGTC_3305 9127027 53.8275 µM -0.761804177276293 0.228924730154392 no 2651 0.223088443439508 3712 41905295 SGTC_856 0433-0016 11.3 µM -0.762261748100885 0.228781304742693 no 2652 0.222951899559857 3829 3911780 SGTC_2306 7482397 179.52 µM -0.763141482362989 0.228505694129309 no 2653 0.222689511523375 3751 891448 SGTC_3083 9117465 49.47 µM -0.765786251877775 0.227678242561535 no 2654 0.22190174792394 3740 16420915 SGTC_1848 st056003 16.4 µM -0.766130372713988 0.22757070389952 no 2655 0.221799366195813 3815 146492 SGTC_2217 6934799 96.0675 µM -0.766611835637053 0.227420293489212 no 2656 0.221656168186434 3706 675606 SGTC_200 k038-0079 37.545 µM -0.7675289202349 0.227133948588308 no 2657 0.221383552600419 3742 3436683 SGTC_203 k066-0004 30.888 µM -0.769106671342809 0.226641797127399 no 2658 0.220914994049425 3842 6795412 SGTC_2078 5212016 200 µM -0.770032038651697 0.226353425469125 no 2659 0.220640443963812 3692 1899708 SGTC_1796 st049173 110.4 µM -0.770063544827277 0.226343610868009 no 2660 0.220631099741266 3729 94134 SGTC_3131 9127911 49.47 µM -0.770668441911945 0.226155223834964 no 2661 0.220451741004857 3804 45595681 SGTC_873 0591-4978 488 µM -0.77085444760561 0.226097312689033 no 2662 0.220396605044122 3811 3305145 SGTC_1621 st003705 32.4 µM -0.771415159511038 0.225922790964765 no 2663 0.220230446194719 3823 24207032 SGTC_223 busulfan 5 mM -0.771764694963912 0.225814036517445 no 2664 0.220126902783981 3792 2478 A DNA alkylator. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.774230656393043 0.225047619210837 no 2665 0.219397201168948 3818 368090 SGTC_821 1114-0266 29.2 µM -0.77547377344347 0.22466181971487 no 2666 0.219029878481773 3809 3123235 SGTC_682 0kpi-0099 17 µM -0.776673660321025 0.224289792692408 no 2667 0.218675665350203 3829 1714895 YML126C ERG13 SGTC_2093 5331342 194.4 µM -0.777519995977367 0.224027595330927 no 2668 0.218426020888454 3825 33839 SGTC_1959 st077091 55.8 µM -0.777959994463154 0.223891351285942 no 2669 0.218296298979273 3802 821356 YKL052C ASK1 SGTC_1547 harmine 94.2 µM -0.778035528036153 0.223867967306594 no 2670 0.21827403436885 3818 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.778525700720117 0.223716251462149 no 2671 0.218129580696328 3813 165521 SGTC_1564 D-Arginine 115 µM -0.78135484752442 0.222841731029069 no 2672 0.217296909882012 3796 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3257 9139206 32.98 µM -0.781892220785382 0.222675843428786 no 2673 0.217138958586985 3819 4910041 SGTC_2111 5486399 200 µM -0.782286575658825 0.222554150525645 no 2674 0.217023087210928 3769 689674 SGTC_1803 st050068 52.4 µM -0.78264216647835 0.222444452235835 no 2675 0.216918636331748 3874 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1788 fluconazole 20 µM -0.783336828733648 0.22223024080727 no 2676 0.216714670814556 3855 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1120 ficusin 1.78878 µM -0.783995625274808 0.222027198002712 no 2677 0.216521338638252 3918 6199 A DNA cross-linker. SGTC_2571 chrysanthemic acid 100 µM -0.785557145776721 0.22154635659344 no 2678 0.216063489495877 3840 2743 An insecticide. SGTC_3189 9110682 49.47 µM -0.786383443407703 0.221292154501852 no 2679 0.215821440095137 3895 17122418 SGTC_2264 7948757 110.76 µM -0.786824362075299 0.221156578628439 no 2680 0.215692345033483 3795 2971411 SGTC_1274 0865-0114 173 µM -0.787117572116934 0.221066447255517 no 2681 0.215606521862188 3825 870624 SGTC_599 1935-0052 86.5 µM -0.787450219435215 0.220964218507313 no 2682 0.215509179300279 3805 9557311 SGTC_714 4296-0578 26.1 µM -0.788541413674991 0.220629064124395 no 2683 0.215190042212473 3853 1589775 SGTC_1526 st051518 75 µM -0.791124167411832 0.219836946799308 no 2684 0.214435768819597 3824 673993 SGTC_5 0352-0601 109.883 µM -0.791763192927321 0.219641213147898 no 2685 0.214249383844198 3734 762456 SGTC_2116 5511452 16.8835 µM -0.792359009261155 0.21945880466586 no 2686 0.21407568664961 3873 870744 SGTC_653 0203-0016 55.2 µM -0.792496894111131 0.219416603782531 no 2687 0.21403550102425 3857 295302 SGTC_2673 kobusone 100 µM -0.79331429381421 0.219166527109066 no 2688 0.21379736548032 3852 6710676 An epoxy ketone and protein crosslinker. SGTC_1301 naphtanilide LB 4.81 µM -0.794641921280291 0.218760699885841 no 2689 0.213410912737822 3866 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2290 7904846 200 µM -0.795267972624292 0.21856947956877 no 2690 0.213228819807331 3892 2962154 SGTC_1358 1509-0022 2.48 µM -0.795939133606593 0.218364587946955 no 2691 0.213033706983451 3861 3258434 SGTC_2907 7721985 69.9 µM -0.796211169166842 0.218281572614663 no 2692 0.212954653357136 3837 3267881 SGTC_1677 st019204 53.9 µM -0.796295521902251 0.218255834929733 no 2693 0.212930143900964 3861 3945625 SGTC_1227 3909-8010 46.6 µM -0.797490769329843 0.217891329312685 no 2694 0.212583030823812 3827 15982272 SGTC_3091 9116372 49.47 µM -0.798282894658773 0.217649954357314 no 2695 0.212353171064265 3913 17169793 SGTC_224 benfluorex 43.875 µM -0.799645280379199 0.21723517180745 no 2696 0.211958172440658 3796 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2190 6049624 200 µM -0.801285042588962 0.216736547114402 no 2697 0.211483323988315 3728 2265554 SGTC_2403 6032726 181.2 µM -0.802074788728594 0.216496634655442 no 2698 0.211254848789462 3899 2881040 SGTC_1857 st056007 79.3 µM -0.80409064871848 0.215884945272909 no 2699 0.210672312398386 3840 619834 SGTC_2556 citropten 84.59 µM -0.806410659540115 0.215182205925204 no 2700 0.210003051337795 3883 2775 A potential DNA crosslinker. SGTC_2701 st077767 14.721 µM -0.807102967391655 0.214972760982106 no 2701 0.209803581325515 3840 5721188 SGTC_967 1306-0166 352 µM -0.809489791029129 0.214251579923495 no 2702 0.209116736355004 3792 4437607 SGTC_2833 9001315 45.46 µM -0.810061780559587 0.214078962028141 no 2703 0.208952334504562 3833 2989378 SGTC_1925 st057770 10.1 µM -0.810417398707707 0.213971682599458 no 2704 0.208850160743245 3843 5989122 SGTC_281 1672-3440 14.9 µM -0.8108669444158 0.213836112812456 no 2705 0.208721042495456 3889 6833000 SGTC_105 0111-0055 734.78 µM -0.811065161442248 0.213776352269844 no 2706 0.208664125668822 3863 5179370 SGTC_1027 k015-0025 8.67 µM -0.811430584985069 0.213666206056263 no 2707 0.208559220479739 3833 3598955 SGTC_1317 1273-0028 910 nM -0.811746572315451 0.213570987599493 no 2708 0.208468532431686 3834 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2489 cantharidin 73.42 µM -0.812711273057184 0.21328044124977 no 2709 0.208191808192691 3806 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_592 k241-0073 46.5 µM -0.81388528828041 0.212927165140639 no 2710 0.207855334701496 3840 4230158 SGTC_2656 pseudo-anisatin 100 µM -0.814080460979962 0.212868468315009 no 2711 0.207799429232456 3896 6708809 A neurotoxin. SGTC_2364 9055074 200 µM -0.814445842811937 0.212758607674973 no 2712 0.207694792763083 3873 6470630 SGTC_1790 st045711 43.5 µM -0.815423942209578 0.212464682044874 no 2713 0.207414842120164 3827 585119 SGTC_852 0418-0143 439 µM -0.815912604960752 0.212317924419395 no 2714 0.207275061152842 3906 5369229 SGTC_1505 k297-0037 20.6 µM -0.81673922216165 0.212069805548164 no 2715 0.207038735870791 3856 4089396 SGTC_2728 chlorpromazine 9.18 µM -0.817397510930845 0.211872333768873 no 2716 0.206850648837827 3863 2726 A thorazine and dopamine antagonist. SGTC_757 1066-0008 322 µM -0.818988564780739 0.211395497951998 no 2717 0.206396468934373 3903 6842497 SGTC_3276 9139060 49.47 µM -0.820036942739045 0.211081644884235 no 2718 0.206097523721497 3928 4870619 SGTC_64 000l-0018 272.079 µM -0.820231737754832 0.211023359172923 no 2719 0.206042006176169 3795 6811119 SGTC_2872 9044037 25.97 µM -0.824808811843015 0.209656544471013 no 2720 0.204740071550506 3856 6465195 SGTC_399 oxolinic acid 75 µM -0.825939428061565 0.209319721257081 no 2721 0.204419226492875 3832 4628 A DNA gyrase inhibitor. SGTC_2432 5630864 12.22 µM -0.827235618596945 0.20893396371685 no 2722 0.204051763408875 3899 5714970 SGTC_260 nsc-65238 3.989 µM -0.828355386594265 0.208601048459034 no 2723 0.203734632214426 3835 3246252 SGTC_991 3996-0057 64.7 µM -0.828514777352666 0.208553685852936 no 2724 0.203689514817594 3925 715343 SGTC_2878 9043973 25.97 µM -0.829857149712227 0.208155054535223 no 2725 0.203309777210158 3959 6465167 SGTC_3014 9081533 49.47 µM -0.830322387689811 0.208017002313846 no 2726 0.203178266800897 3907 21367265 SGTC_3066 9117245 49.47 µM -0.830348128195349 0.208009365792606 no 2727 0.203170992126988 3940 17176980 SGTC_2606 farnesol 9.78 µM -0.831047822445511 0.207801848575383 no 2728 0.202973307028788 3905 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2168 5727979 200 µM -0.83211397214651 0.207485882218452 no 2729 0.20267230798585 3802 695210 SGTC_2278 7948257 134.34 µM -0.832710332110809 0.207309267641181 no 2730 0.202504057994278 3882 1247028 SGTC_3089 9117425 49.47 µM -0.832974459243655 0.207231073663358 no 2731 0.202429566958804 3847 9401657 SGTC_2766 oltipraz 83.91 µM -0.834157800301231 0.206880963584354 no 2732 0.202096033787715 3829 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2529 gangaleoidin 93.61 µM -0.836017989965659 0.206331305485843 no 2733 0.201572391256861 3907 4565183 SGTC_392 N-ethylmaleimide 8.33 µM -0.836174633628882 0.206285059178541 no 2734 0.201528333276147 3832 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.836568391614729 0.206168836141258 no 2735 0.201417609424034 3910 5357218 A potent inhibitor of glutathione S-transferases. SGTC_809 3998-0021 90 µM -0.836908741471521 0.206068408527873 no 2736 0.201321933199502 3839 715485 SGTC_499 genistein 192 µM -0.838430779166944 0.205619653326795 no 2737 0.200894404495721 3888 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2016 5121758 140 µM -0.838982717192195 0.205457064218745 no 2738 0.200739504034464 3845 2795203 SGTC_1404 3909-7820 48.3 µM -0.839252493424926 0.205377621710127 no 2739 0.200663817888158 3832 23741373 SGTC_1926 methyl fluorone black 53.6 µM -0.839806404652874 0.205214565585187 no 2740 0.200508470930685 3675 72721 Reacts with homocysteine. SGTC_1071 trifluoperazine 6.31 µM -0.839891280529308 0.20518958727554 no 2741 0.200484673482888 3990 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2885 9057732 51.95 µM -0.840044835068066 0.205144401961128 no 2742 0.200441624263298 3920 6471414 SGTC_1607 st000305 50.6 µM -0.840843779824657 0.204909398061743 no 2743 0.200217728646968 3894 5457690 SGTC_1151 3909-8316 15.3 µM -0.841152605121673 0.204818602215101 no 2744 0.200131223992537 3939 800431 SGTC_197 4544-0043 41.561 µM -0.842818318010227 0.204329288800858 no 2745 0.199665030789742 3880 896523 SGTC_1922 5578187 25 µM -0.844339311929452 0.203883095942797 no 2746 0.199239912216942 3884 1350412 SGTC_3220 9131269 49.47 µM -0.84479025732361 0.203750920041462 no 2747 0.199113977597172 3921 17722206 SGTC_805 3852-0218 479 µM -0.844836111010205 0.203737482800733 no 2748 0.199101174816213 3828 6615355 SGTC_626 0214-0009 33 µM -0.844944577661075 0.203705699182551 no 2749 0.199070891880377 3954 3437874 SGTC_2877 9040724 71.43 µM -0.845256653578159 0.203614269115447 no 2750 0.198983778506128 3838 6463895 SGTC_858 0438-0351 2.77 µM -0.846948169679165 0.2031191251658 no 2751 0.198512005809622 3893 2799119 SGTC_1309 pyrazolanthrone 13.4 µM -0.849350466432933 0.202417156820653 no 2752 0.197843153477893 3898 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2582 agaric acid 100 µM -0.84976500548818 0.202296172460392 no 2753 0.19772787456931 3723 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2541 muurolladie-3-one 83.07 µM -0.850580272618675 0.202058360726138 no 2754 0.197501275888244 3941 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2947 9072639 7.68 µM -0.850600769527517 0.202052383977066 no 2755 0.197495580917635 3950 16488146 SGTC_965 1291-5240 308 µM -0.850992972626002 0.201938040797301 no 2756 0.197386628241821 3897 2834598 SGTC_640 3381-0960 37.1 µM -0.852384628241561 0.201532629173066 no 2757 0.197000324503871 3936 1745025 SGTC_253 dyclonine 31.25 µM -0.855346924804794 0.200671290069218 no 2758 0.196179558464908 3991 3180 An oral anasthetic. SGTC_3124 9127567 49.47 µM -0.85671252114082 0.200274964606513 no 2759 0.195801890846977 3893 17592030 SGTC_3208 9114115 49.47 µM -0.858913688707125 0.199637129295127 no 2760 0.195194068308107 3947 650895 SGTC_1763 st044482 94.5 µM -0.864712616935945 0.19796262783631 no 2761 0.193598271363148 3954 88505 SGTC_2175 5807670 165.306 µM -0.865096202676747 0.197852163368629 no 2762 0.193492994379493 3911 241186 SGTC_1006 4099-6547 255 µM -0.865418152497773 0.197759477474617 no 2763 0.193404660636753 3969 3146833 SGTC_2714 st079313 56.9 µM -0.866673565180718 0.197398308352 no 2764 0.193060446703137 3900 2939799 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.867485365019852 0.197164974526128 no 2765 0.192838063537191 3938 229346 A bile salt which induces apoptosis. SGTC_652 0437-0092 114 µM -0.867864414878754 0.197056082243747 no 2766 0.192734280830125 3875 3091274 SGTC_923 1900-2434 73.3 µM -0.871423236380984 0.196035490994964 no 2767 0.191761551486321 3894 5910570 SGTC_2923 7992654 58.14 µM -0.871507860465279 0.196011261772985 no 2768 0.191738457915113 3947 2985126 SGTC_2989 9073649 71.4286 µM -0.871661513181802 0.195967273199101 no 2769 0.191696531062237 3844 21367202 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.872163535896151 0.195823593035786 no 2770 0.191559584457223 3952 551469 SGTC_1597 7-benzyloxygramine 47.5 µM -0.873753159964688 0.195369060510351 no 2771 0.191126346931648 3903 260807 SGTC_1299 1079-1439 3.74 µM -0.875715867390717 0.194808734644585 no 2772 0.190592258550382 3892 323161 SGTC_1082 camptothecin 424.86 nM -0.875730817135915 0.194804470453193 no 2773 0.190588193971926 3858 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_547 1120-0019 610 nM -0.877001308502145 0.194442289235664 no 2774 0.190242963675457 3871 3676939 SGTC_1600 coumarin 106 71.1 µM -0.877628645517931 0.194263604433028 no 2775 0.190072639322114 4015 100336 A hepatotoxic, DNA x-linker. SGTC_426 0988-0037 14.6 µM -0.879324602008656 0.19378104486921 no 2776 0.189612650121558 3953 5383008 SGTC_1182 1222-0449 220 µM -0.879386883824401 0.193763337413131 no 2777 0.18959577065804 3945 658318 SGTC_1386 3228-0095 33.8 µM -0.879470719421835 0.193739503519903 no 2778 0.189573051201678 3964 870181 SGTC_1553 gossypol 38.6 µM -0.879834146016723 0.19363620446737 no 2779 0.189474581923668 3805 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2981 9013952 38.96 µM -0.880567381473746 0.193427894555108 no 2780 0.189276009945747 3931 2996344 SGTC_1539 benzyladenosine 56 µM -0.881483058156629 0.193167945719087 no 2781 0.18902820991926 3923 92208 A nucleotide analog. SGTC_3145 9085516 49.47 µM -0.882357106190699 0.192920013756531 no 2782 0.188791861923535 4006 25236195 SGTC_1613 st002381 52.1 µM -0.883852383314145 0.192496315224373 no 2783 0.188387952244312 3936 551167 SGTC_3036 9090181 49.47 µM -0.884004119060343 0.192453351523154 no 2784 0.188346994644283 3969 25236586 SGTC_1997 st073024 93.8 µM -0.884666217431845 0.192265948184739 no 2785 0.188168340593209 3954 686268 SGTC_2695 st077686 51.995 µM -0.884770924436442 0.192236321662097 no 2786 0.188140097074387 3992 2876092 SGTC_685 1278-0033 54.9 µM -0.88592680693499 0.191909453882372 no 2787 0.187828484849147 3970 3590572 SGTC_2133 5320837 200 µM -0.886580813102432 0.191724660668208 no 2788 0.187652313809935 3983 2841355 SGTC_845 0330-0138 4.51 µM -0.887644497240499 0.19142434340669 no 2789 0.187366005055813 3903 9039800 SGTC_1408 3909-7976 48.8 µM -0.888112348408921 0.191292343093996 no 2790 0.187240160476613 4005 24152374 SGTC_3063 1327-0034 4 µM -0.888871711395353 0.191078213951327 no 2791 0.187036015109451 3860 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1853 st056710 91.2 µM -0.889676761896514 0.190851362193018 no 2792 0.186819737645868 4034 269167 SGTC_2086 5274770 176.623 µM -0.889800076635322 0.190816628456631 no 2793 0.186786622717842 4019 689278 SGTC_2239 6685329 187.64 µM -0.889909943859885 0.1907856857135 no 2794 0.186757122044614 4026 805680 SGTC_2247 cerulenin 830 nM -0.890191739227819 0.190706335615261 no 2795 0.186681469779807 3972 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2417 cerulenin 830 nM -0.890651434245038 0.190576934650107 no 2796 0.186558098366303 3986 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2200 6600604 21.907 µM -0.89108153517644 0.190455913036862 no 2797 0.186442715043897 3925 2904777 SGTC_514 4466-0038 2.65 nM -0.891089260167937 0.190453739813616 no 2798 0.186440643061982 3826 5722064 SGTC_1196 1588-0294 184 µM -0.891560443628018 0.190321213527449 no 2799 0.186314290135016 3970 6144269 SGTC_2058 5236698 133 µM -0.891582294505361 0.190315069067464 no 2800 0.1863084318741 3968 766665 SGTC_1419 3993-2473 62.6 µM -0.891777476796979 0.190260189272635 no 2801 0.186256108201066 4019 704026 SGTC_347 4534-1311 26.2 µM -0.893576530045384 0.189754803776383 no 2802 0.185774254204928 3964 2862016 SGTC_2752 diclazuril 33.15 µM -0.893709094237343 0.189717596865667 no 2803 0.185738779151663 3944 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_827 3253-0474 693 µM -0.896649528598685 0.188893456486858 no 2804 0.184952980189168 3983 5402065 SGTC_1210 3013-0140 750 nM -0.896923542954213 0.188816768688486 no 2805 0.184879858215551 4003 905973 SGTC_745 0469-0705 296 µM -0.901455660703848 0.187551159242278 no 2806 0.183673049249874 4053 3486736 SGTC_2179 6298986 200 µM -0.901937394218559 0.187416942400647 no 2807 0.183545062820436 3929 738374 SGTC_293 4049-0273 38.5 µM -0.90203486471184 0.187389793153737 no 2808 0.183519173729592 3850 1380311 SGTC_3079 9117512 49.47 µM -0.902909821645321 0.187146193175919 no 2809 0.183286878765275 3992 7185044 SGTC_1681 tripelennamine 100 µM -0.905900055549148 0.186315150569982 no 2810 0.18249437746655 3948 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1415 3966-0071 78.1 µM -0.906758294641242 0.186077052616826 no 2811 0.18226731437907 3921 2893185 SGTC_1452 4194-0072 190 µM -0.907791061684778 0.185790786222965 no 2812 0.181994310851304 4034 1343545 SGTC_1354 1498-1681 81 µM -0.908667778234066 0.185547989007782 no 2813 0.181762758761826 3992 5754243 SGTC_695 3505-6186 243 µM -0.908706694060696 0.18553721625451 no 2814 0.181752484866514 3997 1819379 SGTC_3224 9130643 49.47 µM -0.912408829232623 0.184514159584189 no 2815 0.180776771700204 4013 17644395 SGTC_1545 lovastatin 49.4 µM -0.912484834911717 0.184493192819736 no 2816 0.180756774547103 4067 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1614 st002383 48.6 µM -0.912873879210651 0.184385895096627 no 2817 0.180654438407898 3978 1947235 SGTC_730 1436-0052 41.2 µM -0.913023373880978 0.184344675060664 no 2818 0.18061512425371 3996 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_568 1193-0097 7.48 µM -0.914837924082074 0.183844807937149 no 2819 0.180138361153851 3858 3646150 SGTC_2883 9059145 45.46 µM -0.916408829931944 0.18341274175366 no 2820 0.179726252897771 3968 16476510 SGTC_2627 acetyl isogambogic acid 100 µM -0.916565486315982 0.183369689298326 no 2821 0.179685188484831 4018 6857789 A caspase activator and apoptosis inducer. SGTC_1439 4092-1168 46 µM -0.920319452820279 0.182339905814429 no 2822 0.17870292323433 4001 2886240 SGTC_1769 st044406 64.4 µM -0.920357924393661 0.182329371080235 no 2823 0.178692874271474 3977 670903 SGTC_2546 rhodinyl acetate 100 µM -0.920650151826157 0.182249362378445 no 2824 0.178616554655017 3919 6708682 SGTC_2009 4012297 12.05 µM -0.920792193555693 0.18221048081901 no 2825 0.178579465722428 4011 45595307 SGTC_2206 7254556 146.969 µM -0.92337786213743 0.181503603477723 no 2826 0.17790516214693 4003 4398905 SGTC_3065 9113888 49.47 µM -0.923545187772831 0.18145791873606 no 2827 0.177861581520705 4070 16648368 SGTC_114 0364-0001 490.298 µM -0.92405306622867 0.181319297305162 no 2828 0.177729343800903 4059 4003655 SGTC_1429 4049-0205 9.46 µM -0.925388757566562 0.180955047484181 no 2829 0.177381862321652 4024 22774478 SGTC_316 k060-0003 58.6 µM -0.926799483313078 0.180570833687778 no 2830 0.177015326645354 4025 6152314 SGTC_6 0844-0013 19.835 µM -0.92755956072384 0.180364037432795 no 2831 0.176818041363046 4135 1584900 SGTC_832 4083-0019 164 µM -0.929084357819139 0.179949630161463 no 2832 0.176422685115367 4067 1990758 SGTC_733 4069-0007 56.1 µM -0.929395871562808 0.179865040996128 no 2833 0.176341983279116 3998 5717425 YNL287W SEC21 SGTC_2822 7994718 71.43 µM -0.92952379085349 0.179830312729577 no 2834 0.176308850827903 3988 1018011 SGTC_1720 st037298 9.481 µM -0.930199320818196 0.179646985819173 no 2835 0.176133946745444 4035 597396 SGTC_1266 0828-0227 32.9 µM -0.930311669170642 0.179616507852929 no 2836 0.176104868853519 4024 3913820 SGTC_1440 4100-1550 40 µM -0.930517826065776 0.179560589869885 no 2837 0.176051519430055 4005 742806 SGTC_1660 st012960 28.1 µM -0.931901057868334 0.179185685198866 no 2838 0.175693830438583 4014 24207266 SGTC_96 0929-0093 37.281 µM -0.932177343975707 0.179110860940156 no 2839 0.175622441004236 3997 6991579 SGTC_3052 9092717 49.47 µM -0.934028188240335 0.178610119256696 no 2840 0.175144676359833 4037 25237534 SGTC_750 4073-0104 132 µM -0.934693940601234 0.178430217276184 no 2841 0.174973025258505 3795 22330957 SGTC_534 k292-0788 63.4 µM -0.935154053473931 0.178305950666446 no 2842 0.174854456639018 4040 4146317 SGTC_2227 7312221 64.1025 µM -0.936495722201954 0.177943906205205 no 2843 0.174509007029448 4073 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1443 4112-3303 14 µM -0.937332051399096 0.177718460513819 no 2844 0.174293890482593 4043 704433 SGTC_1638 st008370 60.6 µM -0.938849649163456 0.177309828586438 no 2845 0.173903971812533 3974 24207134 SGTC_3130 9127414 49.47 µM -0.939630870085414 0.177099706716467 no 2846 0.17370346798999 4019 1494646 SGTC_2635 hydroquinidine 100 µM -0.939854004022511 0.177039720165928 no 2847 0.173646226685258 3939 442912 An experimental heart treatment. SGTC_3341 9147222 25.867 µM -0.941677451107965 0.176549992202502 no 2848 0.173178901489731 4036 1939759 SGTC_3011 9081274 71.4286 µM -0.942918321786396 0.176217218697779 no 2849 0.172861341298696 4024 6625322 SGTC_616 4092-0450 108 µM -0.94365727157539 0.176019237758637 no 2850 0.172672407722476 4040 787165 SGTC_1286 0929-0070 131 µM -0.944359650084689 0.17583118567489 no 2851 0.172492946720839 4116 1420408 SGTC_3172 9105863 49.47 µM -0.945543216916034 0.175514590109565 no 2852 0.172190809057824 4047 2348785 SGTC_1067 clotrimazole 1.36 µM -0.945652253652612 0.175485441758134 no 2853 0.172162991461367 4045 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_456 gingerol 170 µM -0.945986459144837 0.175396119067019 no 2854 0.172077746382482 4037 442793 A herb. SGTC_771 0250-0039 27.3 µM -0.947391899508725 0.175020804295643 no 2855 0.17171955865907 3978 3005115 SGTC_2321 7390090 138.78 µM -0.947451252583532 0.175004965619564 no 2856 0.171704442541351 4054 649046 SGTC_3351 9150312 21.596 µM -0.948540581100329 0.174714434175334 no 2857 0.171427161916805 3943 4904905 SGTC_1812 st052057 4.327 µM -0.948583340901847 0.174703036089873 no 2858 0.171416283562032 4044 3645418 SGTC_2709 st078560 56 µM -0.949412932808943 0.174481992868146 no 2859 0.171205317635724 4012 17250903 SGTC_2155 5570423 76 µM -0.950253854605828 0.174258112195459 no 2860 0.170991640023667 3962 797402 SGTC_2621 lithochol-11-enic acid 100 µM -0.952694817269616 0.173609283242846 no 2861 0.170372360024141 3954 6708711 SGTC_2964 9083345 53.42 µM -0.954307444036409 0.173181477474144 no 2862 0.16996402053301 4038 17741579 SGTC_1986 st071812 45 µM -0.954388027820618 0.173160117428337 no 2863 0.169943632071939 3967 11838594 SGTC_573 3702-0553 84.7 µM -0.954460136453358 0.173141005282134 no 2864 0.169925389233796 3977 1222756 SGTC_1762 st045503 25.4615 µM -0.956215279706805 0.172676224956057 no 2865 0.169481740927413 4128 4645554 SGTC_700 3453-2283 142 µM -0.956618326521005 0.172569606338552 no 2866 0.169379967643258 4098 565664 SGTC_78 0336-0123 156.75 µM -0.957945897832429 0.172218718706699 no 2867 0.169045020275013 3866 6765896 SGTC_1855 st056195 39.6 µM -0.961001736844081 0.171412767676145 no 2868 0.168275647271272 3995 4028379 SGTC_3163 9099914 49.47 µM -0.961527862830411 0.171274250159643 no 2869 0.16814341140946 4042 16268368 SGTC_1648 st011736 69.8 µM -0.961657226190947 0.171240202568024 no 2870 0.1681109076243 4054 2855514 SGTC_729 4092-0585 94.1 µM -0.963600442701749 0.17072928148976 no 2871 0.167623142399601 4063 2169061 SGTC_1263 0774-1208 64.8 µM -0.964232259896898 0.170563371079125 no 2872 0.167464747036818 4091 906585 SGTC_1261 0712-0010 12.7 µM -0.964519736158251 0.170487916171576 no 2873 0.167392709219519 4074 2840123 SGTC_205 1486-1330 71.903 µM -0.966079210809795 0.170078967931842 no 2874 0.167002273164302 4068 4118834 SGTC_3197 9113331 49.47 µM -0.966487884078214 0.169971903702613 no 2875 0.16690005335361 4076 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2488 5268135 45.7 µM -0.967013738278554 0.169834203987687 no 2876 0.166768582932836 4102 1270356 YLR208W SEC13 SGTC_1503 4585-0012 61.3 µM -0.967117411841387 0.169807064564189 no 2877 0.166742671074951 4112 2922052 SGTC_1180 1193-0155 285 µM -0.967476268666079 0.169713145336369 no 2878 0.166652999541148 4132 2921347 SGTC_789 1309-1135 70.6 µM -0.967996700698017 0.169576998204286 no 2879 0.166523008723893 4032 3092424 SGTC_483 fpl-64176 144 µM -0.968289197893298 0.169500510516805 no 2880 0.166449979027431 4110 3423 SGTC_2026 5148700 152 µM -0.96871533022896 0.169389117015015 no 2881 0.166343620779449 4026 79838 SGTC_1097 itavastatin 7.23 µM -0.969290785846062 0.169238764110002 no 2882 0.166200062639827 4054 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2806 7952793 58.44 µM -0.969505975816723 0.169182562090891 no 2883 0.166146400051541 4126 2972490 SGTC_2440 5628896 157.78 µM -0.970013425913519 0.169050076788978 no 2884 0.166019899976409 4045 5522048 SGTC_2394 5221648 200 µM -0.971963478415669 0.168541576406796 no 2885 0.165534358970192 4113 788586 SGTC_2783 7738165 71.43 µM -0.973609968901142 0.168113000056417 no 2886 0.16512511733404 4060 17201110 SGTC_1470 k295-0292 231 µM -0.975077036892862 0.167731718137829 no 2887 0.164761024105953 4134 5045612 SGTC_2187 6125751 200 µM -0.975414605592255 0.167644064984297 no 2888 0.164677320814261 4075 874498 SGTC_976 1348-1067 47.6 µM -0.975725081016857 0.167563472925691 no 2889 0.164600359879108 4078 5310671 YGL099W LSG1 SGTC_3335 9143315 29.6265 µM -0.975851484945686 0.167530668612907 no 2890 0.164569033433641 4073 4899691 SGTC_52 0329-0193 875 nM -0.978927880278588 0.1667335591768 no 2891 0.163807807657434 4177 3739292 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.978979076565613 0.166720314697494 no 2892 0.163795158969101 4054 3256 An antibiotic and ribosome inhibitor. SGTC_168 3970-0862 530.542 µM -0.979171729834567 0.166670481381359 no 2893 0.163747567230687 4036 3135186 SGTC_959 1222-0044 107 µM -0.979762900780017 0.166517624139561 no 2894 0.163601584463948 4056 6083612 SGTC_2540 epiandrosterone 100 µM -0.979802371404963 0.166507421565987 no 2895 0.163591840663973 4095 441302 A steroid. SGTC_908 3448-7491 47.7 µM -0.980523186996882 0.16632117235935 no 2896 0.163413964915093 4065 1203031 SGTC_2338 7999974 200 µM -0.980673608977878 0.166282322284474 no 2897 0.163376861114405 4076 315925 SGTC_531 3788-1495 174 µM -0.980842800965064 0.166238631410462 no 2898 0.163335133954752 4023 2896655 SGTC_2240 6690706 185.951 µM -0.981466896953705 0.166077533652966 no 2899 0.163181275472753 3915 805876 SGTC_585 0kpi-0023 191 µM -0.981693797636948 0.166018988840904 no 2900 0.163125360964796 4008 64601 SGTC_1035 k081-0041 55.2 µM -0.985471951916619 0.165046111311578 no 2901 0.162196151027585 4102 731709 SGTC_2655 perillic acid 100 µM -0.988513780194601 0.164265525934233 no 2902 0.161450544499459 4101 5702197 An apoptosis inducer. SGTC_489 paxilline 115 µM -0.988629437577179 0.164235893581355 no 2903 0.161422238981232 4076 105008 A toxic potassium channel blocker. SGTC_2232 chlorophetanol 41.5365 µM -0.990046397821195 0.163873138361464 no 2904 0.161075720591454 4142 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1184 1269-1718 139 µM -0.991154550420527 0.163589803428707 no 2905 0.160805059785325 4147 5403821 SGTC_1074 carmofur 3.8 µM -0.991803523888494 0.163424020220295 no 2906 0.160646689168806 4111 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2279 7948423 32.93 µM -0.991845322328094 0.163413346361643 no 2907 0.160636492484164 4022 1247112 SGTC_1153 4055-0057 267 µM -0.996550535533982 0.162214694391061 no 2908 0.159491362925891 4133 882706 SGTC_300 r073-0011 5.04 µM -0.997210483241336 0.162047031790117 no 2909 0.159331176757339 4079 2735780 SGTC_840 0245-0196 390 µM -1.00021554293761 0.161285010857046 no 2910 0.158603104471508 4177 3827528 SGTC_2173 5763948 167 µM -1.00021779900171 0.161284439645381 no 2911 0.158602558688325 4068 2867177 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.00071506439022 0.161158569486794 no 2912 0.158482291144754 4094 16486 A toxic proline analog. SGTC_1581 himbacine 57.9 µM -1.00183669597245 0.160874892203837 no 2913 0.158211235414377 4084 5281825 An alkaloid muscarinic receptor antagonist. SGTC_77 0828-0286 12.516 µM -1.00210764668343 0.160806413659545 no 2914 0.158145802574136 4008 745345 SGTC_2112 5488546 200 µM -1.00266172289139 0.160666438845171 no 2915 0.158012052067261 4053 600757 SGTC_468 gf-109203x 121 µM -1.00369290578758 0.160406145741864 no 2916 0.157763328783016 4069 2396 A protein kinase C inhibitor. SGTC_258 haloperidol 50.781 µM -1.00420756228857 0.160276338329385 no 2917 0.157639288903808 4097 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2069 5228469 200 µM -1.00454032073135 0.160192446066807 no 2918 0.157559123280225 4102 2835210 SGTC_22 0964-0034 14.468 µM -1.00485296040666 0.160113652137488 no 2919 0.157483828928074 4118 138402 SGTC_2967 9089538 49.85 µM -1.00666722678025 0.159656906605638 no 2920 0.157047358227907 4114 728216 SGTC_81 0411-0046 9.971 µM -1.00683541661119 0.159614607674409 no 2921 0.157006935967131 4040 12925265 SGTC_1112 tnp00069 1.16933 µM -1.00751166286604 0.159444609036336 no 2922 0.15684447796994 4110 145826 SGTC_482 fipronil 114 µM -1.00856077568317 0.159181111747001 no 2923 0.156592663368601 4177 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1056 3448-1962 115 µM -1.00962119477501 0.158915064767324 no 2924 0.156338405587639 4103 715507 SGTC_698 k064-0052 127 µM -1.01098428431936 0.158573509526542 no 2925 0.15601197583212 4181 5088751 SGTC_419 nsc-638432 893 µM -1.01227214830063 0.158251246502339 no 2926 0.155703973935477 4061 368090 SGTC_1883 5-benzylidenerhodanine 20 µM -1.01462213692263 0.157664315684805 no 2927 0.155142991451031 4087 1273210 SGTC_3329 9141233 27.5565 µM -1.01505669803451 0.157555937012173 no 2928 0.155039400650391 4085 4909101 YNL103W MET4 SGTC_60 0986-0278 202 µM -1.0164753697889 0.157202463961886 no 2929 0.154701535287916 4058 3110598 SGTC_3120 9124077 49.47 µM -1.01838591232426 0.156727262097453 no 2930 0.154247297215993 4207 18774327 YGL155W CDC43 SGTC_14 0354-0009 295 µM -1.01839807387002 0.156724240234526 no 2931 0.154244408594698 4188 1713507 SGTC_1865 st057639 52.2 µM -1.0192675061035 0.156508305792538 no 2932 0.154037992969456 4086 688818 SGTC_1021 4476-0760 85.3 µM -1.02068020274298 0.15615786273544 no 2933 0.153702988522773 4101 746768 SGTC_2375 9072683 200 µM -1.02113775753424 0.156044469540599 no 2934 0.153594588257717 4178 16798029 SGTC_604 1000-0114 314 µM -1.02145012707422 0.155967087955203 no 2935 0.153520613219227 4132 1572745 SGTC_2643 anethole 100 µM -1.023446176688 0.155473214872616 no 2936 0.153048467967074 4100 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_384 k007-0144 5.16 µM -1.02351780440265 0.155455511565148 no 2937 0.153031543068103 4060 6824886 SGTC_2326 6164455 177.58 µM -1.0238646000521 0.155369817322734 no 2938 0.152949616336708 4081 2888790 SGTC_305 1682-2595 20.8 µM -1.02582037433999 0.15488712336611 no 2939 0.152488130269974 4138 226033 SGTC_2304 7443016 91.4 µM -1.02842196477121 0.154246575811225 no 2940 0.151875690394485 4043 939854 SGTC_3041 9091929 49.47 µM -1.02860995503093 0.154200357976222 no 2941 0.151831499044047 4126 25236887 SGTC_2044 5102272 200 µM -1.03091090784094 0.153635405671908 no 2942 0.151291300477172 4119 592666 SGTC_2566 crystal violet carbinol 226 nM -1.03201459431264 0.153364904801489 no 2943 0.151032640347299 4182 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_648 0375-0473 33.3 µM -1.03341946006433 0.153021045024664 no 2944 0.150703821734469 4092 1713139 SGTC_1061 3448-9325 110 µM -1.03490997059085 0.152656781730164 no 2945 0.150355478911087 4044 723482 SGTC_707 0865-0008 204 µM -1.03528776426105 0.152564544840715 no 2946 0.150267271160427 4139 723043 SGTC_1949 st076024 69.1 µM -1.03667944286562 0.152225090844007 no 2947 0.14994263781226 4060 2921930 SGTC_1943 st076331 65.2 µM -1.03799304957437 0.151905140297628 no 2948 0.149636645470645 4138 24208415 SGTC_2226 7298446 200 µM -1.04011008401221 0.151390442530453 no 2949 0.149144379608516 4113 3283010 SGTC_1141 3253-0389 52.6 µM -1.04406920637541 0.150431008373745 no 2950 0.148226685827724 4138 5402031 SGTC_3206 9114350 49.47 µM -1.04482535347242 0.15024822915535 no 2951 0.148051847389263 4036 17087243 SGTC_2256 7954252 200 µM -1.04528521207588 0.150137142509257 no 2952 0.147945585122394 4157 2972920 SGTC_232 clozapine 119 µM -1.0460711640765 0.149947409252643 no 2953 0.147764088733912 4089 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1579 chlormadinone acetate 49.4 µM -1.04730983900878 0.149648710820279 no 2954 0.147478349834667 4165 45114258 A steroidal progestin. SGTC_3304 9125678 46.087 µM -1.04857651067545 0.149343671999009 no 2955 0.147186535713297 4078 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3312 9133330 71.43 µM -1.04954728129554 0.149110172994693 no 2956 0.14696315305671 4180 17617324 SGTC_2106 5357045 167.29 µM -1.04968070343579 0.149078100099475 no 2957 0.146932469257906 4158 668842 SGTC_2357 9067248 200 µM -1.05186275943586 0.148554217016 no 2958 0.146431259996015 4126 9150235 SGTC_1974 st069448 26.9 µM -1.05208661873613 0.148500541032829 no 2959 0.146379905431409 4129 6323587 YNR016C ACC1 SGTC_2344 7990960 76.95 µM -1.05210759651629 0.148495511739077 no 2960 0.146375093632081 4119 140813 SGTC_2723 salbutamol 83.58 µM -1.05261018345425 0.148375053664718 no 2961 0.146259844000278 4177 9884233 β2-adrenoceptor agonist SGTC_2234 tolnaftate 200 µM -1.0532129431364 0.148230672795658 no 2962 0.146121703861456 4185 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3241 9133421 49.47 µM -1.06168461462478 0.146211372596904 no 2963 0.144189443109129 4196 17018221 SGTC_2731 amoxapine 43.43 µM -1.06438440433373 0.145571753355899 no 2964 0.14357729792368 4279 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_91 0417-1751 58.384 µM -1.06442067531895 0.14556317306306 no 2965 0.143569085868653 4271 6795624 SGTC_2785 7756463 72.73 µM -1.06538144753326 0.145336015842142 no 2966 0.143351674408551 4118 2201551 SGTC_3159 9100096 49.47 µM -1.06746592204061 0.144843999866804 no 2967 0.142880747065288 4096 25236875 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.06801933659185 0.144713561429667 no 2968 0.142755894736578 4194 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1137 ixabepilone 100 µM -1.06902250251174 0.144477319451951 no 2969 0.142529764931561 4121 154225 A novel microtubule stabilizer. SGTC_2218 6965428 192.983 µM -1.0693098369686 0.14440970112069 no 2970 0.142465039757801 4048 675684 SGTC_799 1310-0557 151 µM -1.06976216279204 0.1443032986395 no 2971 0.142363188793655 4229 5354492 SGTC_1791 st048313 56.1 µM -1.07087009161339 0.144042899230082 no 2972 0.142113922745449 4174 1204976 SGTC_94 0334-0113 514.748 µM -1.07179061579272 0.143826787187007 no 2973 0.141907044511879 4181 6795178 SGTC_2642 cholecalciferol 100 µM -1.07329793403561 0.143473385706627 no 2974 0.141568730929814 4159 9821465 A vitamin D precursor, similar to steriods. SGTC_42 0133-0086 60.653 µM -1.07791123975575 0.1423954085715 no 2975 0.140536684487527 4049 162923 Model of phenazepam hydroxylation. SGTC_1940 st075990 51.1 µM -1.07811232645687 0.142348546196706 no 2976 0.140491815676176 4264 1084979 SGTC_69 0096-0274 206.684 µM -1.08051090149472 0.14179037327226 no 2977 0.139957367465857 4306 6741392 SGTC_1336 1486-0901 104 µM -1.08387874732792 0.141009145966531 no 2978 0.13920928192639 4200 5006114 SGTC_530 4358-1714 28 µM -1.08484730527396 0.140785014542806 no 2979 0.138994644932851 4179 1564641 SGTC_1623 st003709 20.3 µM -1.08787832696419 0.140085176352897 no 2980 0.138324412555039 4140 16192618 SGTC_1850 st056238 17 µM -1.08805237932159 0.140045060968114 no 2981 0.138285992356661 4203 5393177 SGTC_1012 4112-3522 18 µM -1.08882373985166 0.139867372643385 no 2982 0.138115810324015 4217 3112398 SGTC_2425 5628681 7.85 µM -1.08972702507683 0.139659489402393 no 2983 0.13791670391286 4250 5714958 SGTC_2202 7226349 200 µM -1.09013809652623 0.139564954475816 no 2984 0.137826158455415 4140 844334 SGTC_1052 3253-3998 198 µM -1.09308769483818 0.13888790594226 no 2985 0.137177649084449 4122 5450317 SGTC_2913 7966556 36.57 µM -1.09537082304306 0.138365376450461 no 2986 0.136677105600815 4068 2976516 SGTC_2385 9074692 200 µM -1.09571037778968 0.138287778660437 no 2987 0.136602769846259 4206 17046906 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.09993635637658 0.137324505967588 no 2988 0.135679926333628 4217 5377381 SGTC_857 0438-0306 1.35 µM -1.10296328332299 0.136637368945534 no 2989 0.135021555157265 4264 4686136 SGTC_1981 st071826 47 µM -1.10315267708803 0.136594453313053 no 2990 0.134980434061286 4235 11838600 SGTC_2099 5377090 177.372 µM -1.10418585777097 0.136360502299451 no 2991 0.134756261545484 4210 2243829 SGTC_1302 1159-0335 255 µM -1.10624360403376 0.135895368135943 no 2992 0.13431054717548 4213 649284 SGTC_2381 9035592 200 µM -1.10641581527301 0.13585649073029 no 2993 0.134273291637205 4197 4749657 SGTC_3053 9095903 49.47 µM -1.10683029950189 0.135762950414182 no 2994 0.13418365276225 4300 17174018 SGTC_2780 5215298 71.43 µM -1.1071588368205 0.135688837842 no 2995 0.134112630497538 4229 2834131 SGTC_2733 amorolfine 100 µM -1.10849035336799 0.135388753577256 no 2996 0.133825051484707 4319 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2724 maprotiline 69.64 µM -1.11141718038769 0.134730733432351 no 2997 0.133194410300781 4128 4011 A tricyclic antidepressant. SGTC_2564 betulinic acid 100 µM -1.11162970207218 0.134683039123676 no 2998 0.1331486981879 4272 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_278 4092-0821 23.9 µM -1.11329809809246 0.134309018706583 no 2999 0.132790211507082 4209 877900 SGTC_1008 4106-0037 6 µM -1.11376445409015 0.134204598866765 no 3000 0.132690125007935 4204 2905394 SGTC_894 0960-0238 55.9 µM -1.11402580223614 0.134146105872817 no 3001 0.13263405877626 4203 6741907 YDL195W SEC31 SGTC_795 0685-0265 78 µM -1.11484735522638 0.133962346073372 no 3002 0.132457919773939 4217 302754 SGTC_1238 0333-0287 48.8 µM -1.11560915426665 0.133792106292289 no 3003 0.132294735963506 4176 7226 SGTC_3281 9140613 49.47 µM -1.11662713392547 0.133564849865797 no 3004 0.132076892480512 4212 16013766 SGTC_1957 st077035 62.4 µM -1.11691150858882 0.133501412789311 no 3005 0.132016081692049 4217 705593 SGTC_329 k048-0121 21.3 µM -1.11903623107974 0.133028094655169 no 3006 0.13156234130159 4219 6832902 SGTC_762 1165-0429 115 µM -1.12034354499972 0.132737442906242 no 3007 0.131283696284768 4227 5967793 SGTC_1017 4239-0030 168 µM -1.120559057783 0.132689570528004 no 3008 0.13123780036887 4230 1149593 SGTC_1991 st073000 8.92 µM -1.12364219671698 0.132006007269758 no 3009 0.130582423690385 4281 4301969 YIL048W NEO1 SGTC_1350 1495-0454 146 µM -1.12765237288201 0.131120549698726 no 3010 0.12973337953672 4259 1069057 SGTC_2663 amphotericin b 100 µM -1.12830208188857 0.130977479331647 no 3011 0.129596182277401 4235 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1507 4075-3230 155 µM -1.12940189732692 0.130735538364092 no 3012 0.129364166416615 4155 659771 SGTC_1275 0867-0008 21.1 µM -1.13436481187646 0.12964762371338 no 3013 0.128320776476531 4190 3422836 SGTC_2721 ifenprodil 61.44 µM -1.13679256453315 0.129117729228992 no 3014 0.127812506205787 4231 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2416 tofa 880 nM -1.14641777149927 0.127031666389999 no 3015 0.125811166437308 4230 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_589 1227-0070 34.1 µM -1.14738729133801 0.126822850954683 no 3016 0.125610795625651 4296 2841384 SGTC_977 1348-1378 135 µM -1.14839118336915 0.126606884389786 no 3017 0.125403555865357 4225 X977 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.1502849807657 0.126200170816818 no 3018 0.125013257378176 4253 7104 SGTC_1039 k821-0043 94 µM -1.15130181430431 0.125982170908127 no 3019 0.124804045509824 4238 15992768 SGTC_3267 9137951 49.47 µM -1.15170865825031 0.125895020838574 no 3020 0.124720406586534 4270 16643986 SGTC_472 calcifediol 10 µM -1.15559222795898 0.125065237006398 no 3021 0.123923994267902 4294 5283731 A vitamin D metabolite. SGTC_3301 9125354 19.7965 µM -1.15627086277279 0.124920629319129 no 3022 0.123785191254546 4232 41905162 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.16033377959281 0.124057321141503 no 3023 0.122956468230012 4303 279621 SGTC_55 0767-0285 6.563 µM -1.16167504254327 0.123773241825904 no 3024 0.122683743541041 4166 3116166 SGTC_3243 9134147 49.47 µM -1.16236965501845 0.123626302124007 no 3025 0.122542671935147 4357 24282180 SGTC_2414 st077232 92.9 µM -1.16524251294519 0.12301986962303 no 3026 0.121960420778837 4196 729801 SGTC_3019 9081971 49.47 µM -1.16762723693394 0.122518063882065 no 3027 0.12147857935577 4276 16451803 SGTC_441 propafenone 146 µM -1.17067186975681 0.12187948655375 no 3028 0.120865348258553 4240 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1852 st056254 31.4 µM -1.1745910171982 0.121060936548181 no 3029 0.120079189405285 4210 442583 SGTC_712 r015-0009 80.6 µM -1.17603163930649 0.120761023669401 no 3030 0.119791116538001 4294 6813872 YLR060W FRS1 SGTC_2100 5377183 190 µM -1.17672514054654 0.120616835204002 no 3031 0.119652614998069 4282 2844202 SGTC_2379 9035213 200 µM -1.18297216680871 0.119323454666907 no 3032 0.118410089209761 4265 646551 SGTC_3023 9089636 49.47 µM -1.18402836900786 0.119105750124814 no 3033 0.118200916564311 4344 17249241 SGTC_1003 4049-0218 100 µM -1.18764298427236 0.118362827584682 no 3034 0.11748704771335 4295 295161 SGTC_544 k015-0020 52.4 µM -1.18775569549169 0.11833971449993 no 3035 0.117464836981862 4279 3008304 SGTC_1051 3253-3903 78 µM -1.18974274794038 0.11793276420307 no 3036 0.117073759064676 4266 5509239 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.19372467696608 0.117120243421043 no 3037 0.116292842131663 4201 5355888 SGTC_2628 lathosterol 100 µM -1.19801191237992 0.116249866973993 no 3038 0.115456189736617 4352 6710616 SGTC_1402 3909-7673 35.9 µM -1.19847067129145 0.116157004235979 no 3039 0.115366917084049 4306 5328014 SGTC_2185 6113692 200 µM -1.2002793641376 0.115791398622675 no 3040 0.115015430694686 4280 874150 SGTC_515 4092-1064 102 µM -1.2025673131476 0.115330088851121 no 3041 0.114571901507498 4295 717353 SGTC_3282 9108498 15.4605 µM -1.20259522532267 0.115324469110587 no 3042 0.114566498133416 4256 16459645 SGTC_2811 7967822 32.47 µM -1.2030754013371 0.115227822610386 no 3043 0.114473571730904 4328 2232244 SGTC_1914 st062367 72.6 µM -1.20359929375136 0.115122442870851 no 3044 0.114372246299223 4289 978205 SGTC_3002 9075603 71.4286 µM -1.20409907851523 0.115021976212482 no 3045 0.114275643030973 4228 20105405 SGTC_1819 st053448 58.6 µM -1.20411562623013 0.115018650860035 no 3046 0.114272445521462 4193 2857616 SGTC_2558 carylophyllene oxide 100 µM -1.20665209717437 0.114509741526568 no 3047 0.113783077178714 4409 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2471 5466956 24.79 µM -1.20993870192869 0.113852714437983 no 3048 0.113151207537574 4279 724419 SGTC_171 k064-0041 9.68 µM -1.21294923153853 0.113253239162066 no 3049 0.1125746156628 4306 53325 SGTC_3353 9151644 39.2805 µM -1.21315106842941 0.113213128848211 no 3050 0.112536034041355 4314 4909158 SGTC_1622 st003707 19.4 µM -1.21333092358266 0.11317739542564 no 3051 0.112501662242308 4312 10140899 SGTC_2939 9044578 71.43 µM -1.21501925084124 0.112842352711377 no 3052 0.11217937458841 4243 2653634 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.2168411161791 0.112481604792563 no 3053 0.111832336481013 4258 688761 SGTC_1950 st077106 7.18 µM -1.2176526670454 0.112321174956705 no 3054 0.111677995618522 4226 13831864 SGTC_166 k072-0058 166.424 µM -1.21793980779035 0.112264451282403 no 3055 0.111623423662404 4184 5846229 SGTC_1570 verbenone 133 µM -1.22167658818607 0.111528129201387 no 3056 0.110914976560929 4324 29025 A natural terpanoid with antifungal properties. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.22311673615249 0.111245276685192 no 3057 0.110642804116737 4328 6708561 SGTC_1504 k297-0033 30 µM -1.2271635828539 0.110453205292387 no 3058 0.109880556950659 4190 4388117 SGTC_2079 5212404 121 µM -1.22888791141769 0.110116941408494 no 3059 0.109556917228893 4269 758462 SGTC_3228 9131799 49.47 µM -1.22905963573297 0.110083493447307 no 3060 0.109524723760981 4336 17015818 SGTC_2031 5180455 200 µM -1.22951130745508 0.10999555294569 no 3061 0.109440080480682 4293 29949 SGTC_2641 levomentholum 100 µM -1.23030866229927 0.109840430985978 no 3062 0.109290770881142 4299 16666 SGTC_2970 9090938 41.86 µM -1.23050248874822 0.109802746616762 no 3063 0.1092544978075 4381 17217104 SGTC_928 2764-0428 58.7 µM -1.23279858184916 0.10935703866833 no 3064 0.10882546029123 4331 662578 SGTC_365 0121-0052 13.6 µM -1.23352010887828 0.109217247601275 no 3065 0.108690889507666 4323 3101739 SGTC_655 k060-0012 42 µM -1.23569483519528 0.108796685637803 no 3066 0.108286009045075 4292 5994525 SGTC_3006 9075424 71.4286 µM -1.23699020840386 0.108546732437826 no 3067 0.108045358896603 4272 7465181 SGTC_1144 3486-0183 12.5 µM -1.23812931045437 0.108327274651624 no 3068 0.107834058675193 4315 6744069 SGTC_2160 5660466 132.927 µM -1.24565667568515 0.106885086633017 no 3069 0.106445232764554 4244 2859134 SGTC_1897 st060201 15 µM -1.24931762988565 0.106188703115894 no 3070 0.105774461103767 4335 611878 SGTC_158 k038-0087 26.446 µM -1.2503585709946 0.105991295957157 no 3071 0.105584295679211 4233 X158 SGTC_2059 5238311 157 µM -1.25180729751975 0.105716996722984 no 3072 0.105320045196087 4282 703021 SGTC_1383 3049-0032 20.7 µM -1.25258946118013 0.105569116794156 no 3073 0.105177576101846 4385 712864 SGTC_2429 5902844 64.44 µM -1.26181682586764 0.103835824449407 no 3074 0.103507353109039 4331 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2569 tetrandrine 100 µM -1.26217331324726 0.103769277543002 no 3075 0.103443214626809 4338 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2068 5226020 147 µM -1.2689059705825 0.102518270710508 no 3076 0.102237301302508 4353 1810509 SGTC_2996 9066192 71.4286 µM -1.26938076811216 0.102430463439993 no 3077 0.102152646022063 4353 6472854 SGTC_89 0302-0250 142.109 µM -1.27846232302228 0.100761468604834 no 3078 0.100543230668384 4440 4203518 YLR208W SEC13 SGTC_48 0382-0018 55 µM -1.27953083577081 0.100566410436728 no 3079 0.100355094052734 4389 762596 SGTC_98 0074-0023 107.663 µM -1.27997739968005 0.1004849713791 no 3080 0.100276542220113 4362 3563821 SGTC_2023 5144124 124 µM -1.28105179729317 0.100289232587503 no 3081 0.100087736584538 4333 2830192 SGTC_1015 4130-4525 82 µM -1.28130308006267 0.100243492896736 no 3082 0.10004361573142 4357 1363237 SGTC_1226 3909-7979 35.4 µM -1.28167803025195 0.100175270985605 no 3083 0.0999778074533034 4348 6615510 SGTC_3115 9123671 49.47 µM -1.28172493199394 0.100166739633752 no 3084 0.099969577857172 4497 3286988 SGTC_405 ebelactone b 50 µM -1.28325459176683 0.0998887876429896 no 3085 0.0997014477991311 4286 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_960 1222-0186 7.7 µM -1.28544301437265 0.0994921130268786 no 3086 0.0993187590610674 4355 3126296 SGTC_1447 4239-0816 81.9 µM -1.28631103167513 0.0993350950741667 no 3087 0.0991672669916749 4359 1341554 SGTC_2814 7977482 42.97 µM -1.28999426680036 0.0986708401147947 no 3088 0.0985263243497692 4363 6456762 SGTC_1268 0828-0275 2.46 µM -1.29069290688865 0.0985452111861424 no 3089 0.0984050926111979 4421 745337 SGTC_342 k048-0088 23.3 µM -1.29461571672998 0.0978419886852 no 3090 0.0977264139351847 4348 6820570 SGTC_87 0100-0052 35.5 µM -1.29502991932311 0.0977679519024863 no 3091 0.0976549542379226 4399 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1467 k284-1082 293 µM -1.29519714720235 0.0977380723394443 no 3092 0.0976261143517893 4332 3334705 SGTC_414 piperonyl butoxide 100 µM -1.30365378031398 0.0962357942389181 no 3093 0.0961758274973685 4366 5794 A potent inhibitor of cytochrome P450. SGTC_1550 gossypolone 36.6 µM -1.30414417386089 0.0961492018666465 no 3094 0.0960922149641045 4398 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2957 9076800 11.52 µM -1.3081544784931 0.0954432217072232 no 3095 0.0954104592560655 4338 16459615 SGTC_2893 9048488 25.97 µM -1.31129311504852 0.0948933586102804 no 3096 0.094879376788625 4401 6467338 SGTC_3212 9128307 49.47 µM -1.31286342076026 0.09461913164098 no 3097 0.0946144873700198 4281 27243542 SGTC_877 0771-0151 33.1 µM -1.31295682304562 0.0946028389585057 no 3098 0.0945987488566949 4386 6166523 SGTC_912 3474-0017 2.18 µM -1.321589012346 0.0931059912866238 no 3099 0.0931525220863903 4403 3360550 SGTC_268 camptothecin 39.6153 µM -1.32172957156806 0.0930817635658995 no 3100 0.0931291089152162 4355 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_336 4111-0029 111 µM -1.32366455425926 0.0927487105673864 no 3101 0.0928072377092975 4384 3131175 SGTC_3121 9125696 49.47 µM -1.32602010429413 0.0923444591315472 no 3102 0.0924165191192535 4492 1235365 SGTC_3101 9120531 49.47 µM -1.33117845032509 0.0914637583230158 no 3103 0.0915651501842591 4385 24824904 SGTC_2222 6885208 172.143 µM -1.33323748131477 0.0911139572626863 no 3104 0.0912269414271832 4389 609514 SGTC_318 1488-0629 67.2 µM -1.33752736603428 0.0903883534659342 no 3105 0.0905252778191731 4436 3662576 SGTC_2889 9059656 51.95 µM -1.33930907689239 0.0900882540205774 no 3106 0.0902350375072575 4458 3949838 SGTC_1715 st032160 10.2275 µM -1.34237070237714 0.0895743042676984 no 3107 0.089737914630904 4315 5289825 SGTC_1807 st050092 58.9 µM -1.34444098932394 0.0892280065243803 no 3108 0.0894029133097781 4411 5008496 SGTC_2919 7978188 46.38 µM -1.34524380650015 0.0890939873478968 no 3109 0.0892732568982992 4413 2980291 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.34613505003145 0.0889453821565834 no 3110 0.0891294833919623 4387 75037 A free radical scavenger. SGTC_3085 9117376 49.47 µM -1.34782600777651 0.0886639405882338 no 3111 0.0888571754265358 4479 16480349 SGTC_2352 9027995 87.8 µM -1.34898708530791 0.0884710762573808 no 3112 0.08867055716193 4354 2997347 SGTC_849 0386-0493 241 µM -1.34925167920408 0.0884271688432625 no 3113 0.0886280702489469 4416 726119 SGTC_1911 st060208 74.3 µM -1.35093486197083 0.08814823712341 no 3114 0.0883581497605043 4438 688783 SGTC_577 r071-0003 38.6 µM -1.35376711420849 0.0876803664725885 no 3115 0.0879053442647183 4370 4568517 YMR134W ERG29 SGTC_2413 inermin 26.06 µM -1.35385050003736 0.0876666197779209 no 3116 0.087892039254117 4451 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_282 k297-0036 65.7 µM -1.35743359776809 0.0870774408832471 no 3117 0.087321739432295 4411 5061378 SGTC_2303 7774051 200 µM -1.35921347725761 0.0867858719411431 no 3118 0.0870394759128997 4405 2953184 SGTC_215 1287-0124 461.5 µM -1.36001759009993 0.0866543865981017 no 3119 0.0869121787905019 4424 5560863 SGTC_909 3448-9333 149 µM -1.36108853598379 0.0864795010450657 no 3120 0.0867428560282431 4337 3344074 SGTC_2465 5809242 33.21 µM -1.36674822998148 0.0855596525619079 no 3121 0.0858521173954828 4472 2731748 SGTC_2333 9017922 200 µM -1.36678196224411 0.0855541922356898 no 3122 0.0858468291169154 4434 3163164 SGTC_496 calpeptin 138 µM -1.36716785658337 0.0854917451149418 no 3123 0.0857863489875882 4410 73364 A calpain inhibitor. SGTC_2572 astragaloside iv 100 µM -1.3696052977895 0.0850980961983201 no 3124 0.0854050724804276 4419 45006101 An anti-inflammatory agent. SGTC_1149 3909-7961 23.3 µM -1.36993708979228 0.0850446167050651 no 3125 0.0853532702511764 4471 735261 SGTC_2735 sertaconazole 140 nM -1.37001210036117 0.085032529709012 no 3126 0.0853415622169338 4560 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_602 3130-1533 38.1 µM -1.37234515584388 0.0846572301048387 no 3127 0.0849780073214569 4464 720941 SGTC_149 3970-0822 46.1 µM -1.37488702231644 0.0842497563546692 no 3128 0.084583236638311 4408 3114250 YBL034C STU1 SGTC_126 0417-1624 672.48 µM -1.37530331673782 0.0841831628171822 no 3129 0.0845187143406494 4470 41912 YDL195W SEC31 SGTC_869 0564-0080 44.1 µM -1.37828192178944 0.0837078353844835 no 3130 0.0840581312818226 4421 6843321 SGTC_625 k213-0058 121 µM -1.37936070772348 0.0835361803992092 no 3131 0.0838917837850929 4485 3655420 SGTC_1575 cyproterone acetate 48 µM -1.38032879746448 0.0833823645618034 no 3132 0.0837427160915152 4418 9880 An androgen receptor antagonist and liver toxin. SGTC_1653 st012112 65 µM -1.38051414229548 0.083352940172488 no 3133 0.0837141991658997 4420 720429 SGTC_7 0192-1582 4.227 µM -1.38192491120449 0.083129229537291 no 3134 0.0834973790584469 4475 252616 SGTC_1627 st003713 25.6 µM -1.39145923545846 0.0816291605133398 no 3135 0.0820431064127074 4439 16195070 YER133W GLC7 SGTC_427 1354-0053 47.3 µM -1.39195399770819 0.081551878495659 no 3136 0.0819681643613255 4464 6813657 SGTC_1108 betulinic acid 729.144 nM -1.3928414509575 0.0814133962747589 no 3137 0.0818338703340729 4415 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2974 9094440 9.66 µM -1.39305973290834 0.0813793617646117 no 3138 0.0818008642017393 4416 25236134 SGTC_978 1416-0512 87.4 µM -1.39689193295114 0.080783592138234 no 3139 0.0812230354200338 4475 6814003 SGTC_995 3931-2021 34.6 µM -1.39723058637739 0.0807311024684452 no 3140 0.0811721208753596 4449 730143 SGTC_2174 5790901 200 µM -1.39830011379495 0.0805654999107272 no 3141 0.0810114818628337 4407 786020 SGTC_997 3996-0078 137 µM -1.39840688223625 0.0805489822878149 no 3142 0.080995458824156 4480 735687 SGTC_3045 9092950 49.47 µM -1.40175987488154 0.0800315578490716 no 3143 0.0804934821081576 4425 44120432 SGTC_1663 st014140 55.4 µM -1.40738228035274 0.0791695696012971 no 3144 0.0796570313407835 4508 4207120 SGTC_2680 butyl paraben 22.24 µM -1.41277852430167 0.0783488839402241 no 3145 0.0788604273177831 4530 7184 An antifungal and steroid mimetic. SGTC_1378 2093-0007 380 nM -1.41746221905615 0.0776418095137152 no 3146 0.0781739164162874 4490 3618014 SGTC_2427 5545055 42.75 µM -1.42183743758005 0.0769856905726582 no 3147 0.0775367243003176 4374 5372858 SGTC_3140 9094243 49.47 µM -1.42210468069444 0.0769457510988688 no 3148 0.0774979320920656 4399 19291112 SGTC_1254 0550-0035 264 µM -1.42304766321274 0.0768049482260865 no 3149 0.0773611693292781 4451 15121435 SGTC_2790 5423970 71.43 µM -1.42661939222441 0.076273405901892 no 3150 0.0768448157313774 4468 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3146 9095609 49.47 µM -1.43244227832839 0.0754128565906444 no 3151 0.0760086431335209 4496 17173999 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.43441243481552 0.0751233738324883 no 3152 0.0757273006027367 4555 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1973 st070275 50.2 µM -1.43449363948194 0.0751114603228398 no 3153 0.0757157214486155 4409 17118334 SGTC_1193 1488-0126 41.5 µM -1.43535639860146 0.0749849741713466 no 3154 0.0755927819778406 4428 1384710 SGTC_2894 9048625 32.47 µM -1.4392141557313 0.0744213882042291 no 3155 0.0750449279478473 4479 4092861 SGTC_1375 2910-0797 186 µM -1.44287962289211 0.073888895899511 no 3156 0.0745271921483634 4453 742508 SGTC_2470 5664817 21.68 µM -1.44469940820692 0.0736256146982005 no 3157 0.0742711681079202 4515 2859561 SGTC_1615 st002656 86.5 µM -1.44535681081723 0.073530680169752 no 3158 0.0741788440275746 4467 1584458 SGTC_1466 k213-0079 57.5 µM -1.44741802003383 0.0732336308150126 no 3159 0.0738899408892927 4432 3657981 SGTC_2300 7976697 71.57 µM -1.44852033198589 0.0730751493269738 no 3160 0.0737357919639618 4352 2236109 SGTC_677 0929-0063 136 µM -1.45204091351227 0.0725707461101298 no 3161 0.0732451147258123 4489 1539583 SGTC_1993 st073995 70.8 µM -1.45862795957033 0.0716341704763943 no 3162 0.072333766921144 4485 3098394 SGTC_1947 st076332 61.6 µM -1.4622365952 0.0711250252713451 no 3163 0.0718381933105071 4348 24208416 SGTC_2980 9014342 25.29 µM -1.46337266204616 0.0709653131701022 no 3164 0.0716827174816153 4502 2996599 SGTC_823 0417-1665 178 µM -1.46416314083835 0.0708543476186965 no 3165 0.071574689304767 4491 3429856 SGTC_382 3229-0966 23.2 µM -1.46491293650847 0.0707492163002793 no 3166 0.0714723364309724 4512 5722370 SGTC_1194 1488-0194 225 µM -1.46536744967637 0.0706855458888289 no 3167 0.0714103465929083 4445 1391452 SGTC_1772 st048439 82.2 µM -1.46652351662076 0.0705237968594954 no 3168 0.0712528596726354 4512 2927068 YDL195W SEC31 SGTC_1335 1486-0900 202 µM -1.46840957693537 0.0702605230405335 no 3169 0.0709965008670083 4470 X1335 SGTC_2864 9034755 47.6 µM -1.4695864437135 0.0700966284098571 no 3170 0.0708368970070942 4420 4930451 SGTC_642 0335-0876 158 µM -1.47211957999181 0.069744852855386 no 3171 0.0704942944888286 4514 6812350 SGTC_2749 bexarotene 57.39 µM -1.47348182276891 0.069556241484866 no 3172 0.0703105808333042 4482 82146 An retinoic acid receptor inhibitor. SGTC_1984 st072354 53.1 µM -1.47468977280654 0.0693893217055939 no 3173 0.0701479834528606 4357 5762938 SGTC_1154 4088-0362 150 µM -1.475973824596 0.0692122243323877 no 3174 0.0699754596167285 4488 6618304 SGTC_1290 0986-0249 10.2 µM -1.47719483141811 0.0690441453780252 no 3175 0.0698117094385429 4339 53329 SGTC_1131 3454-3128 32.3 µM -1.48471369314239 0.0680160532305975 no 3176 0.0688098414219112 4482 710982 SGTC_556 4058-0063 51.5 µM -1.4847496063523 0.0680111711542894 no 3177 0.0688050828261211 4524 6615692 SGTC_66 0109-0187 42.4 µM -1.48487075234021 0.0679947044478288 no 3178 0.0687890325321848 4347 759417 SGTC_2849 9019321 12.99 µM -1.48492644253313 0.0679871358197029 no 3179 0.0687816552625174 4502 16489627 SGTC_3143 9086658 49.47 µM -1.48713330281933 0.0676877337240115 no 3180 0.0684898036723685 4468 25236626 SGTC_1038 k292-0204 154 µM -1.49138861876906 0.0671132968955606 no 3181 0.0679297472275226 4434 4454212 SGTC_1962 st076595 64.5 µM -1.49152410782105 0.0670950689748284 no 3182 0.0679119733243808 4455 279619 SGTC_2302 7771753 200 µM -1.49627118989397 0.0664588376586352 no 3183 0.0672914997981428 4475 2203047 SGTC_2750 bromebric acid 70.15 µM -1.49649986567092 0.0664283075397709 no 3184 0.0672617214420279 4490 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1729 st035615 45.989 µM -1.50192663319604 0.0657069709848924 no 3185 0.0665580287453011 4499 17385451 SGTC_1839 st053978 48 µM -1.50381302547353 0.0654576552373235 no 3186 0.0663147581882563 4536 3788398 SGTC_2794 7785382 27.27 µM -1.50590010940651 0.0651826705953056 no 3187 0.066046409241065 4487 2205081 SGTC_1240 0356-0016 42.1 µM -1.50698225954376 0.0650404447475545 no 3188 0.0659076022775296 4460 4305613 SGTC_335 4077-0256 27.6 µM -1.50956769659134 0.0647016186889876 no 3189 0.0655768846373754 4433 3121989 SGTC_812 4251-0442 148 µM -1.51296221799165 0.0642588439945956 no 3190 0.0651446280968543 4530 5723007 SGTC_1090 efavirenz 20.7 µM -1.51776478202003 0.0636364342997119 no 3191 0.064536853143537 4533 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2765 myclobutanil 7.74 µM -1.51856748164451 0.0635328639189707 no 3192 0.0644357007853381 4514 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_120 rhodamine 6G 52.259 µM -1.52327707433146 0.0629278371328034 no 3193 0.0638447001469997 4511 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2287 7945887 168.79 µM -1.52687957919023 0.0624680718220098 no 3194 0.0633954791751102 4521 1245853 SGTC_1229 0139-0193 12.2 µM -1.53412903321799 0.0615508111687996 no 3195 0.0624989560126315 4573 3090752 SGTC_1964 st076914 61 µM -1.53709085389975 0.0611790975652776 no 3196 0.0621355311874669 4546 24208661 SGTC_816 0325-0417 81.3 µM -1.53747821711297 0.0611306128080241 no 3197 0.0620881226469527 4551 68101 SGTC_2652 actinonin 100 µM -1.54005462089685 0.0608088980045359 no 3198 0.0617735199314118 4563 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_510 ag-490 170 µM -1.54318560231443 0.0604197171223246 no 3199 0.061392874798599 4643 5328779 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.54375347968897 0.0603493392597675 no 3200 0.0613240325332068 4465 6857784 SGTC_275 trichlorophene 5.69 µM -1.54399514719652 0.0603194085247422 no 3201 0.0612947541236846 4552 62616 SGTC_311 1315-0136 58 µM -1.54444809129533 0.0602633422916824 no 3202 0.0612399086320095 4546 6759207 SGTC_3268 9137683 49.47 µM -1.54933655358637 0.0596608323836776 no 3203 0.0606504184894228 4586 1953228 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.55550553958804 0.0589072448252807 no 3204 0.0599128581435773 4528 61125 An anti-inflammatory. SGTC_3055 9094636 49.47 µM -1.55732533065167 0.0586863762537211 no 3205 0.0596966321487634 4537 25236176 SGTC_888 0916-0002 6.97 µM -1.55958246945137 0.0584133304132533 no 3206 0.0594292909439625 4535 2802138 YIL048W NEO1 SGTC_1459 k035-0031 35.7 µM -1.56123935493046 0.0582135328882643 no 3207 0.0592336432767888 4276 3877128 YMR208W ERG12 SGTC_722 3534-0461 190 µM -1.57282357368424 0.0568315976574932 no 3208 0.0578798377709368 4555 658262 SGTC_35 0133-0054 64.071 µM -1.57727414871872 0.0563075889430448 no 3209 0.0573662290052578 4495 99677 SGTC_1236 0330-0013 258 µM -1.58337026387685 0.0555960252867163 no 3210 0.0566685482443437 4563 4617066 SGTC_1174 0739-0097 51.1 µM -1.58369584801006 0.0555582223458329 no 3211 0.0566314750603131 4558 728447 SGTC_2259 7964009 200 µM -1.58984935911994 0.0548475589600881 no 3212 0.0559343824136933 4555 313134 SGTC_3016 9080866 49.47 µM -1.59942653104324 0.053755815359303 no 3213 0.054862930542873 4521 17066299 SGTC_1979 st071809 45.3 µM -1.6009986044787 0.0535782635881082 no 3214 0.0546886141177163 4585 4976333 SGTC_1458 k015-0034 6.33 µM -1.61544523804961 0.0519683146999427 no 3215 0.0531071551720477 4574 3598957 SGTC_1260 0700-1617 7.75 µM -1.6208715615067 0.0513736227495004 no 3216 0.0525225935204178 4517 2853078 SGTC_353 1988-1175 58.3 µM -1.62285300696598 0.0511578223883795 no 3217 0.0523104156389702 4377 2788357 SGTC_1659 st012954 42.1 µM -1.62404906479586 0.0510279085587691 no 3218 0.0521826687064229 4535 24207262 SGTC_1474 0330-0125 5.35 µM -1.62477736479137 0.0509489305276756 no 3219 0.0521050028756802 4612 X1474 SGTC_2869 9037858 32.47 µM -1.62696359815329 0.0507124361779856 no 3220 0.0518724146080261 4515 27187042 SGTC_1025 k007-0731 70 µM -1.63226293677758 0.0501428109955768 no 3221 0.051312053726634 4541 6256118 SGTC_1864 st057645 30.4 µM -1.63676605840303 0.0496627901662134 no 3222 0.0508396801315151 4603 688666 SGTC_227 fluconazole 33.516 µM -1.63813860319093 0.0495172118819255 no 3223 0.0506963918814442 4555 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_170 4197-0004 226 µM -1.63843783907354 0.0494855188420066 no 3224 0.0506651955816096 4568 218692 SGTC_533 1222-0222 6.71 µM -1.63876110654523 0.0494512987345777 no 3225 0.0506315110939591 4582 3982874 SGTC_818 4072-2707 53.5 µM -1.64077681092498 0.0492383483227554 no 3226 0.0504218767874597 4495 882871 SGTC_3178 9107506 49.47 µM -1.64150473687895 0.0491616263209363 no 3227 0.050346342301795 4543 8897194 SGTC_2836 9010338 19.48 µM -1.64634025169508 0.0486543931760921 no 3228 0.0498468633687947 4521 2994051 SGTC_1879 gemcitabine 100 µM -1.64807912019679 0.0484730163304615 no 3229 0.0496682181712453 4540 60750 A nucleoside analog which inhibits DNA replication. SGTC_214 4373-3496 70 µM -1.64936682612533 0.0483390478624606 no 3230 0.0495362533437587 4626 3779166 SGTC_2098 5376439 882.5 nM -1.65660368656606 0.0475916501891795 no 3231 0.0487998132682005 4608 2844116 SGTC_3239 9133757 49.47 µM -1.65729276264845 0.0475209701148418 no 3232 0.0487301499093815 4637 17036923 SGTC_1838 st055369 84.5 µM -1.68052586748743 0.0451867170125337 no 3233 0.0464275228746502 4554 676036 SGTC_1431 4049-0260 9.09 µM -1.68274504692083 0.0449686667355102 no 3234 0.046212228620072 4611 3854841 SGTC_24 0417-1663 219 µM -1.69273425547924 0.0439976208893029 no 3235 0.0452530308949553 4600 4329390 SGTC_1704 st028805 70.8 µM -1.70056951060601 0.04324785274925 no 3236 0.0445119267345011 4638 2876101 SGTC_1488 4013-0813 75.9 µM -1.70210347010628 0.0431022804329683 no 3237 0.0443679867690549 4603 2910057 SGTC_59 0330-0160 1.33 µM -1.70584651362824 0.0427487276131952 no 3238 0.0440183301701174 4540 4293482 SGTC_1412 3909-8563 178 µM -1.70686437818408 0.0426529907152541 no 3239 0.0439236315684261 4667 23767530 SGTC_1433 4060-0023 7.6 µM -1.70865463245432 0.0424850260653939 no 3240 0.0437574711998314 4609 3840627 SGTC_600 1495-0418 41.6 µM -1.70879969772597 0.0424714392608965 no 3241 0.0437440293764168 4578 5377768 SGTC_15 0266-0086 27.098 µM -1.70900685651426 0.042452042874024 no 3242 0.0437248397113311 4657 1712902 YIL048W NEO1 SGTC_1380 2291-0730 164 µM -1.71192207036503 0.0421798489200526 no 3243 0.0434555154013841 4598 2999191 SGTC_362 0310-0100 9.03 µM -1.72513188426472 0.0409640951929578 no 3244 0.0422518538382549 4616 790235 SGTC_2189 6047310 154.431 µM -1.73189166085986 0.0403530477926385 no 3245 0.0416464268965994 4614 711535 SGTC_1774 st048371 48.465 µM -1.73697681297384 0.0398982729483604 no 3246 0.0411956318510357 4592 4242727 SGTC_429 1112-0049 25.5 µM -1.73715943981484 0.0398820180918523 no 3247 0.0411795159958342 4568 2836170 SGTC_1469 k284-2957 126 µM -1.73745855426569 0.0398554067851881 no 3248 0.0411531317659806 4617 23884841 SGTC_2686 alizarin 95.37 µM -1.73782808450055 0.0398225507316072 no 3249 0.0411205552425418 4567 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1520 flindersine 88 µM -1.73907929135285 0.039711465595874 no 3250 0.0410104083532129 4612 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2971 9092186 9.93 µM -1.74230985933031 0.0394258128054647 no 3251 0.0407271195757533 4566 25236400 SGTC_993 3909-8757 62.7 µM -1.75151831706613 0.038620747069897 no 3252 0.0399283344666299 4586 4288324 YLR208W SEC13 SGTC_1191 1487-1166 10.6 µM -1.7521034012174 0.0385700509803501 no 3253 0.0398780147722716 4614 3955771 SGTC_2781 5567276 71.43 µM -1.76522906848817 0.0374469282971059 no 3254 0.0387626375378763 4588 2853274 SGTC_1225 1216-0074 20.6 µM -1.76662902766962 0.0373287307703301 no 3255 0.0386451881737088 4603 4241466 SGTC_2419 paclitaxel 166.5 µM -1.76771118094426 0.0372375743550772 no 3256 0.0385545999168313 4552 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_521 r062-0005 13.8 µM -1.77005034554901 0.0370411535840143 no 3257 0.0383593771085287 4558 2832033 SGTC_195 4234-0266 16.654 µM -1.77421717370362 0.0366933613026285 no 3258 0.0380136172874622 4635 2303354 SGTC_1213 1315-0166 115 µM -1.78724397658487 0.0356232469840929 no 3259 0.036949032213238 4601 768401 SGTC_2144 5628481 200 µM -1.79571010904085 0.0349415934164813 no 3260 0.0362703166501493 4617 2818399 SGTC_523 1934-0222 13.7 µM -1.79925547164339 0.0346593356281644 no 3261 0.0359891391441668 4610 1361595 SGTC_216 k038-0035 28.382 µM -1.80349894031204 0.0343239641449136 no 3262 0.0356549458575396 4581 4444231 YPR107C YTH1 SGTC_1985 st071382 65.5 µM -1.80542083080948 0.0341729524283217 no 3263 0.035504426952771 4625 6123237 SGTC_581 0958-0271 211 µM -1.81070276635779 0.0337607379599479 no 3264 0.0350934372083691 4635 4591145 SGTC_95 0471-0001 561.058 µM -1.81785518883225 0.0332090759028696 no 3265 0.0345431344298793 4605 4015405 SGTC_892 0929-0076 29 µM -1.82399991350785 0.0327410865471057 no 3266 0.0340760426574898 4636 5751038 SGTC_3275 9138069 49.47 µM -1.82811576595077 0.0324306697117636 no 3267 0.0337660896354341 4652 17617007 SGTC_143 4032-1194 15.74 µM -1.84306441085688 0.03132360438163 no 3268 0.0326598033742514 4647 1806963 SGTC_969 1313-0238 134 µM -1.85901364502028 0.0301770859033938 no 3269 0.0315126021533792 4663 5212874 SGTC_2224 6650123 117.647 µM -1.86081934337936 0.0300495028779745 no 3270 0.0313848464571859 4700 2908370 SGTC_921 1561-0023 372 µM -1.86214658354883 0.029956011145562 no 3271 0.0312912156710756 4620 24050882 SGTC_2280 7785178 200 µM -1.86260959956844 0.0299234527807714 no 3272 0.0312586063860692 4634 2954328 SGTC_1675 st018485 24.5 µM -1.86766502524242 0.0295698712112459 no 3273 0.0309043882787717 4630 3323024 SGTC_1605 st000082 49.1 µM -1.877241265724 0.0289096042198695 no 3274 0.0302425170547594 4631 1114022 SGTC_1107 amlodipine 47 µM -1.87903421549152 0.028787355255754 no 3275 0.0301199107342222 4213 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1859 st055998 20 µM -1.88095544342016 0.0286568372119991 no 3276 0.0299889900882203 4599 676301 SGTC_2472 5377652 49.4 µM -1.8822000501203 0.0285725481806824 no 3277 0.0299044294340518 4675 1610903 SGTC_2271 7849410 118.62 µM -1.88232503279501 0.0285640953312008 no 3278 0.0298959488403756 4592 972430 SGTC_17 0960-0276 49.807 µM -1.88413528978684 0.0284418967984954 no 3279 0.0297733389131218 4654 6821114 SGTC_545 4218-0007 221 µM -1.89043544129486 0.0280200012532538 no 3280 0.0293498735857496 4656 2840508 SGTC_135 0933-0004 26.348 µM -1.89421392963273 0.0277694806740733 no 3281 0.0290983099600327 4578 21230617 YGL099W LSG1 SGTC_1817 st052116 64.4 µM -1.89515119056518 0.027707628303564 no 3282 0.0290361872092061 4668 4361398 SGTC_2317 5986382 200 µM -1.89559356653487 0.0276784746295436 no 3283 0.029006904319045 4666 877883 SGTC_2832 7992762 51.95 µM -1.89661264370623 0.0276114121849645 no 3284 0.0289395403123978 4568 2985177 SGTC_1794 st048918 76.9 µM -1.89717321755537 0.0275745802605933 no 3285 0.0289025401946379 4648 672303 SGTC_1091 telmisartan 47.6 µM -1.8976887704347 0.0275407425551108 no 3286 0.0288685463596593 4677 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_509 pifithrin 175 µM -1.9034838682351 0.0271627639975593 no 3287 0.0284887183379725 4722 4817 A p53 inhibitor. SGTC_1708 st033234 31.827 µM -1.90593817271601 0.0270039945958821 no 3288 0.0283291138533872 4709 674664 SGTC_2593 nobiletin 86.24 µM -1.90946625906616 0.0267771196686392 no 3289 0.0281009851733463 4631 72344 An anti-infammatory. SGTC_1905 st060207 84.5 µM -1.91338115149599 0.0265272362864602 no 3290 0.0278496377842864 4655 1948547 SGTC_2607 solasodine 47.35 µM -1.9169284162849 0.0263025035685109 no 3291 0.0276235132134321 4598 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_36 0335-0881 14.2 µM -1.92352264756443 0.0258889627214559 no 3292 0.0272072225251388 4585 23828853 SGTC_3259 9138485 49.47 µM -1.92597912173001 0.0257363082190338 no 3293 0.0270534904219876 4631 17646153 SGTC_2336 9001819 198.65 µM -1.92765525913066 0.0256325797668533 no 3294 0.0269490103033912 4640 2989602 SGTC_2047 4141938 200 µM -1.94502631141895 0.0245780285968525 no 3295 0.0258859058308727 4685 3807862 SGTC_2236 dapsone 200 µM -1.95397850153337 0.0240489364438205 no 3296 0.0253518798511757 4691 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1706 st031321 9.9705 µM -1.95398164327781 0.0240487524537884 no 3297 0.025351694068815 4696 6103185 SGTC_1068 loratadine 26.9 µM -1.9595668251187 0.0237235319852797 no 3298 0.0250232210461639 4691 3957 A H1 histamine antagonist. SGTC_1028 k015-0029 4.8 µM -1.96746622416766 0.0232698766723004 no 3299 0.024564743056529 4670 4588309 SGTC_925 2064-1272 59.6 µM -1.97782879687087 0.0226858554131134 no 3300 0.0239740118407067 4654 6815817 SGTC_749 1000-0129 128 µM -1.98979275298143 0.0220269961610929 no 3301 0.0233068850426397 4694 708470 SGTC_259 usnic acid 108.925 µM -1.99029295733479 0.0219998052564047 no 3302 0.0232793366845428 4693 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2006 4011487 200 µM -1.9930437285105 0.0218507803631172 no 3303 0.0231283294741029 4627 45595294 SGTC_1465 k213-0056 144 µM -1.99586632852205 0.0216987512213528 no 3304 0.0229742373312021 4622 24048857 YMR208W ERG12 SGTC_1880 MG-132 525 µM -1.99749050525446 0.0216116765619475 no 3305 0.0228859624333181 4651 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2796 7949634 45.45 µM -2.00211494749293 0.0213653686097273 no 3306 0.0226361851353693 4646 2971588 SGTC_308 4092-1169 104 µM -2.03096487603266 0.0198817604492155 no 3307 0.0211292788805654 4644 2268590 YDL196W YDL196W SGTC_2143 5623677 140.463 µM -2.03765196558069 0.0195506416784107 no 3308 0.0207923755783433 4677 5375313 SGTC_1881 5652484 16 µM -2.04594588847801 0.0191464761911332 no 3309 0.020380847412323 4669 2255129 SGTC_2368 9071271 200 µM -2.04698972296061 0.0190961166207134 no 3310 0.0203295468052493 4684 27209959 SGTC_1910 st062352 60.4 µM -2.04839093946268 0.0190286923282679 no 3311 0.0202608543102543 4631 2245730 SGTC_1568 digitonin 820 nM -2.04911174763178 0.0189940871226413 no 3312 0.0202255945089507 4664 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2623 humulene 100 µM -2.07721465724951 0.0176860065745487 no 3313 0.0188908758292361 4678 6187145 An anti-inflammatory. SGTC_172 1112-0046 2.638 µM -2.08979469230144 0.0171258373855613 no 3314 0.0183181231788241 4698 2802135 YIL048W NEO1 SGTC_2273 7815444 169.05 µM -2.10453423936145 0.0164888642929122 no 3315 0.0176659355694555 4649 2824616 SGTC_1549 4'-methoxyflavonol 74.6 µM -2.11041978940234 0.0162402442472192 no 3316 0.0174111066971052 4712 97141 SGTC_422 cantharidin 155 µM -2.15523564149297 0.0144503194653838 no 3317 0.0155716995838209 4657 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_889 0919-1524 82.7 µM -2.17191069176995 0.013829094293613 no 3318 0.0149311999333849 4733 3905452 SGTC_146 3448-8650 53.125 µM -2.18997457870188 0.0131822517618535 no 3319 0.0142630402601094 4690 2891488 YIL048W NEO1 SGTC_244 nsc-207895 1.295 µM -2.19914663383476 0.012863939291288 no 3320 0.0139337487620495 4644 42640 SGTC_2725 haloperidol 53.21 µM -2.2003629130042 0.012822232126169 no 3321 0.0138905784607833 4706 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_958 1222-0007 33 µM -2.21044342362639 0.0124810430055642 no 3322 0.0135372014677474 4735 7312461 SGTC_2706 st078239 82.5 µM -2.2240849807751 0.0120318600196636 no 3323 0.0130713636017686 4712 15434492 SGTC_2142 5622915 118.518 µM -2.29022877494128 0.0100471926305583 no 3324 0.0110040290970986 4749 5322196 SGTC_386 1509-0011 3.07 µM -2.29218029682043 0.00999325589752462 no 3325 0.0109476207115983 4740 3107280 SGTC_3156 9099931 49.47 µM -2.31114547594351 0.00948211682238344 no 3326 0.0104124104138681 4759 18111053 SGTC_1288 0973-0013 65.5 µM -2.31939940687754 0.00926689839018756 no 3327 0.010186694893193 4756 4315430 SGTC_410 α-linolenic acid 100 µM -2.32231585771256 0.00919188153959213 no 3328 0.0101079671481469 4749 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2943 9068529 45.32 µM -2.32990609281239 0.00899913243334755 no 3329 0.00990555746760756 4701 3270634 SGTC_2319 6033012 152.6 µM -2.37374657985315 0.00795362967469725 no 3330 0.00880431566110741 4721 847246 SGTC_1873 rapamycin 2 nM -2.38052756093692 0.00780183890161628 no 3331 0.00864393387683925 4738 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1887 st057648 70.8 µM -2.38591027520697 0.00768316859190924 no 3332 0.00851845355506345 4749 688672 SGTC_948 3448-0295 75.3 µM -2.45725576300993 0.00625392103419502 no 3333 0.00700014863217783 4746 678569 SGTC_2838 9002687 71.43 µM -2.47581068531925 0.00592313823939079 no 3334 0.00664670228215891 4731 6457060 SGTC_2762 leflunomide 42.06 µM -2.51453059461666 0.00528241225600638 no 3335 0.0059595480237542 4750 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2813 7971799 71.43 µM -2.54463651093645 0.00482762413466961 no 3336 0.00546957719956727 4738 2234054 SGTC_754 3474-0146 171 µM -2.57062771023372 0.00446342374307927 no 3337 0.00507571949025041 4761 24762078 SGTC_1588 farnesol 29.9 µM -2.59074892321739 0.00419854274807318 no 3338 0.00478836668191845 4780 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_574 1315-0397 40 µM -2.59119073449396 0.00419288780866337 no 3339 0.00478222325939528 4762 6794277 SGTC_2772 vinpocetine 57.06 µM -2.6074428493707 0.00398954718716433 no 3340 0.00456106484529327 4754 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2408 sulbentine 18.36 µM -2.64841183466561 0.00351559655089708 no 3341 0.00404354701383793 4681 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2378 9074213 121.43 µM -2.71659740751086 0.00283788521458826 no 3342 0.00329783917208315 4775 657714 SGTC_2293 7624732 200 µM -2.79269580102519 0.00222250626906224 no 3343 0.00261354111264796 4737 894453 SGTC_3333 9141820 12.094 µM -2.88944941414314 0.00161540218002438 no 3344 0.00192958546456191 4766 1939433 SGTC_2792 7535235 81.82 µM -3.07366877043001 0.000857576292677291 yes 3345 0.00105722025630655 4764 1281891 SGTC_2768 sulfasalazine 50.2 µM -3.15883598320158 0.000632636733647407 yes 3346 0.000792003044194647 4784 5384001 An antioxidant and salicylic acid derivative. SGTC_504 lovastatin 124 µM -3.17322518038521 0.00060051092501649 yes 3347 0.000753777748056774 4787 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1367 1812-0510 76.9 µM -3.27125578718789 0.000418716648436988 yes 3348 0.000535355097569463 4798 1142582 YDR527W RBA50 SGTC_131 0141-0277 33.849 µM -3.29020739966103 0.000390087053786942 yes 3349 0.000500567811705113 4781 1547771 SGTC_2587 piperic acid 92.2 µM -3.31986245283395 0.00034891194596061 yes 3350 0.000450309048552395 4790 5370536 SGTC_3326 9140064 16.379 µM -3.4381348551355 0.000221650980952421 yes 3351 0.000292867957641522 4796 1868434 SGTC_137 0438-0332 85.389 µM -3.62924952167853 0.000103342364911402 yes 3352 0.000142123193885318 4783 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2830 7992007 71.43 µM -3.66492958751282 8.92538739464912e-05 yes 3353 0.000123703320178405 4776 1952075 SGTC_178 4092-0806 87.505 µM -3.6857820625354 8.18780003320591e-05 yes 3354 0.000114000701863488 4773 2169044 SGTC_436 n,n-dimethylsphingosine 3.3 µM -4.08347560698019 1.45174595135533e-05 yes 3355 2.21835442039822e-05 4808 5282309 SGTC_758 0868-0029 16 µM -6.25878658713876 6.26636837123753e-11 yes 3356 1.93992189082502e-10 4778 762687