SGTCid condition conc unit YNR073C|YNR073C.score YNR073C|YNR073C.strain.pval YNR073C|YNR073C.strain.significant YNR073C|YNR073C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3353 9151644 39.2805 µM 6.3649430568205 5.92587878480562e-10 yes 1 9.76811002148422e-11 1 4909158
SGTC_3141 9094609 49.47 µM 5.77684756812107 1.7720622666883e-08 yes 2 3.80565909475338e-09 6 25236309 YDL196W YDL196W
SGTC_2343 7990716 14.84 µM 5.55964038757728 5.7384161955923e-08 yes 3 1.351655372697e-08 3 6456862
SGTC_1873 rapamycin 2 nM 4.06477377393225 5.84282211717496e-05 yes 4 2.40395367138898e-05 66 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_585 0kpi-0023 191 µM 4.0181633091179 7.02040528088802e-05 yes 5 2.93267711735807e-05 18 64601
SGTC_346 4513-0042 7.16 µM 3.87755773360596 0.000120727951724813 yes 6 5.2755147391032e-05 45 2827372
SGTC_2112 5488546 200 µM 3.79316417549167 0.000165750894138439 yes 7 7.43698721860032e-05 21 600757
SGTC_363 0455-0021 3.06 µM 3.65169582792639 0.000277994219142845 yes 8 0.000130257167676703 78 4597466
SGTC_1082 camptothecin 424.86 nM 3.43550109261648 0.000592096753181874 yes 9 0.000295729539065122 64 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_573 3702-0553 84.7 µM 3.13025945198314 0.00160549548180951 no 10 0.000873259864636341 40 1222756
SGTC_3258 9138477 49.47 µM 3.10546029710374 0.0017348083815663 no 11 0.000949915619421994 28 4970355
SGTC_566 0958-0068 16.5 µM 3.10158964639154 0.00175582580320391 no 12 0.000962422902797369 45 6815365
SGTC_748 act1.228 77.9 µM 3.04814945900141 0.00207066334296353 no 13 0.0011512768813945 130 4421505 YNR035C ARC35
SGTC_2911 7942208 15.64 µM 3.02678378187901 0.00221026835116338 no 14 0.00123585344735755 39 1243384
SGTC_1120 ficusin 1.78878 µM 3.02433088028742 0.00222682999132167 no 15 0.00124591872712744 59 6199 A DNA cross-linker.
SGTC_1164 k060-0068 93.7 µM 3.01322869288989 0.0023032055721223 no 16 0.0012924202407756 75 5963676
SGTC_1990 st072050 59.8 µM 2.988544720577 0.00248158124822333 no 17 0.00140154737711862 50 17233948
SGTC_3074 9116018 49.47 µM 2.97797073649783 0.00256174445368821 no 18 0.00145081843576888 52 17027303
SGTC_1831 st055328 12 µM 2.93871957303743 0.00288019022590885 no 19 0.00164785559429914 70 1103068
SGTC_1986 st071812 45 µM 2.9353176984572 0.0029094043752023 no 20 0.00166603169924702 37 11838594
SGTC_360 0957-0399 1.01 µM 2.93042364340016 0.00295190156272827 no 21 0.00169250086134286 107 6752301 YPR165W RHO1
SGTC_2222 6885208 172.143 µM 2.92804015463621 0.00297280032415978 no 22 0.00170552994499385 14 609514
SGTC_2152 5568786 200 µM 2.84759074065336 0.00376122211199448 no 23 0.00220257669432301 55 5399883
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.82968435862087 0.00396039270485417 no 24 0.00232969734658918 138 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_145 3737-0113 38.366 µM 2.81668511273953 0.00411084589431892 no 25 0.0024261036071376 154 6849351
SGTC_139 0099-0334 718.624 µM 2.81392483175537 0.004143444192277 no 26 0.00244703354110521 98 97690
SGTC_2031 5180455 200 µM 2.80648328980048 0.0042324823697703 no 27 0.00250427550751404 56 29949
SGTC_2449 5812982 45.77 µM 2.76594851722088 0.00474819242971509 no 28 0.00283787472415618 51 776185
SGTC_1830 st055982 50.3 µM 2.68643211483835 0.00592516440306426 no 29 0.00361098109826956 84 455313 An antimicrobial agent.
SGTC_92 0063-0024 660.874 µM 2.68035442305401 0.00602496139563778 no 30 0.00367721229186545 68 3594437
SGTC_2560 caryophyllene 100 µM 2.62523447337664 0.00700026273163118 no 31 0.00432946579918313 100 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_574 1315-0397 40 µM 2.61398733731037 0.00721558572167191 no 32 0.00447461766155936 151 6794277
SGTC_3070 9117005 49.47 µM 2.61020464920242 0.00728930555144281 no 33 0.00452440358961919 53 8779016
SGTC_1763 st044482 94.5 µM 2.578875152172 0.00792583901077929 no 34 0.00495613019676263 97 88505
SGTC_1684 st024538 14.6195 µM 2.56793357120616 0.00815939092543972 no 35 0.00511533796792595 105 6732859
SGTC_805 3852-0218 479 µM 2.55013647858707 0.00855220423131775 no 36 0.00538403781586394 164 6615355
SGTC_2153 5569715 200 µM 2.53988347238562 0.00878595885204214 no 37 0.00554447039697335 73 2054701
SGTC_794 k038-0031 316 µM 2.52999414643147 0.00901670931259943 no 38 0.005703221480195 202 6624242
SGTC_1374 2889-5571 141 µM 2.51938273520649 0.00927019549946133 no 39 0.00587803958816168 155 2853281
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.50137100973003 0.00971475300635608 no 40 0.0061856749999696 97 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1962 st076595 64.5 µM 2.49727221073844 0.00981848160918057 no 41 0.00625764217873885 136 279619
SGTC_197 4544-0043 41.561 µM 2.49483667569639 0.00988057495850073 no 42 0.00630075586998246 163 896523
SGTC_387 norethindrone acetate 66.7 µM 2.4761254640963 0.0103691548437582 no 43 0.00664084478368133 99 541197
SGTC_3031 9088762 49.47 µM 2.46587642570441 0.0106455997263666 no 44 0.00683392392116452 117 205253
SGTC_1485 3909-9022 254 µM 2.4642886161891 0.0106889966432289 no 45 0.00686427574971829 91 714516
SGTC_2081 5214970 32.255 µM 2.45130500530359 0.0110496729627532 no 46 0.0071169642309768 116 2063512
SGTC_2498 4'-Methoxychalcone 54.63 µM 2.44931798456859 0.0111057949173539 no 47 0.00715635142571087 126 641818 YHR062C RPP1
SGTC_1028 k015-0029 4.8 µM 2.44501122754723 0.0112282876744039 no 48 0.00724238163335526 156 4588309
SGTC_1165 k072-0275 30.3 µM 2.42871767726174 0.0117023964644455 no 49 0.00757616311492362 137 6153523 YGL055W OLE1
SGTC_565 1418-0001 44.5 µM 2.42075163319399 0.011940450564525 no 50 0.00774422774187055 139 2862145
SGTC_44 0929-0055 61.211 µM 2.40294987068326 0.0124876592452055 no 51 0.00813170834621479 133 1379590
SGTC_2142 5622915 118.518 µM 2.3940098781465 0.0127705646431483 no 52 0.00833264997729239 100 5322196
SGTC_1603 st002045 67.8 µM 2.38047855558912 0.0132093057767652 no 53 0.00864508368313865 115 5887985
SGTC_2674 ligustilide 100 µM 2.37338796156973 0.0134443690163658 no 54 0.00881286974864059 89 5319022 A signalling regulator.
SGTC_2675 theaflavin digallate 100 µM 2.35992832907396 0.013900521619565 no 55 0.00913923302575852 144 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1614 st002383 48.6 µM 2.34625097640942 0.01437766144772 no 56 0.00948166671376404 128 1947235
SGTC_736 0958-0254 92.6 µM 2.34444624937772 0.0144416612962286 no 57 0.00952767845692139 165 6812352
SGTC_612 0302-0167 22.4 µM 2.33678242166164 0.0147161779640658 no 58 0.00972525015222726 178 235821
SGTC_1385 3091-4834 14.1 µM 2.3349411161482 0.0147827980109287 no 59 0.00977324852509709 120 4072814
SGTC_3101 9120531 49.47 µM 2.32728636353599 0.0150625415051415 no 60 0.00997501453291178 167 24824904
SGTC_233 rapamycin 362 pM 2.31253197225459 0.0156145935529638 no 61 0.0103741927476127 116 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_100 0086-0128 49.5915 µM 2.30692004600737 0.0158290815292283 no 62 0.0105296388923667 200 93297
SGTC_1643 st009866 20.2 µM 2.30681350799703 0.0158331777328577 no 63 0.0105326094394277 113 3156273 YOR207C RET1
SGTC_1856 st057054 55.7 µM 2.2844040096658 0.0167152350717771 no 64 0.0111738990720973 135 1266018
SGTC_1985 st071382 65.5 µM 2.2822699016176 0.0168013867762231 no 65 0.0112367051909228 145 6123237
SGTC_318 1488-0629 67.2 µM 2.27153591445813 0.0172404879681276 no 66 0.0115572776988501 122 3662576
SGTC_924 2046-0044 21.3 µM 2.26234037094008 0.0176244164257992 no 67 0.0118381909827546 132 3623589
SGTC_1182 1222-0449 220 µM 2.24233892572441 0.0184847674628342 no 68 0.0124697378931072 128 658318
SGTC_2855 9016525 58.44 µM 2.24231048821086 0.0184860157033558 no 69 0.012470656185521 163 43811474
SGTC_18 0111-0177 500 nM 2.24168254306147 0.0185135971206313 no 70 0.0124909484583711 255 721752
SGTC_12 0849-0099 9.267 µM 2.23950945857604 0.0186093167585703 no 71 0.0125613932916991 134 6071388
SGTC_3123 9126162 49.47 µM 2.23546122900254 0.0187887561502813 no 72 0.0126935421224116 144 25239884
SGTC_94 0334-0113 514.748 µM 2.22738284678233 0.0191512369567108 no 73 0.0129608489171196 164 6795178
SGTC_1018 4259-0013 28.1 µM 2.22221936467359 0.0193860256101597 no 74 0.013134242201178 146 6801262
SGTC_2349 9023730 187.07 µM 2.2211980070321 0.0194327563320338 no 75 0.0131687765669576 182 4126287
SGTC_1680 diphenhydramine 100 µM 2.21208246347457 0.0198540790715065 no 76 0.0134804837927578 186 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2427 5545055 42.75 µM 2.20618143590558 0.0201309394107091 no 77 0.0136856492762676 173 5372858
SGTC_2408 sulbentine 18.36 µM 2.20333993035069 0.020265418826901 no 78 0.013785399295286 204 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2759 disulfiram 3.38 µM 2.20325067032359 0.0202696555282991 no 79 0.0137885428685675 183 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_533 1222-0222 6.71 µM 2.20248551991778 0.0203060039877992 no 80 0.0138155154288104 187 3982874
SGTC_2280 7785178 200 µM 2.19910606927681 0.0204672063901966 no 81 0.0139351905411542 147 2954328
SGTC_849 0386-0493 241 µM 2.19890137183104 0.020477005349527 no 82 0.0139424680295831 150 726119
SGTC_1071 trifluoperazine 6.31 µM 2.19813338907942 0.0205138044732981 no 83 0.0139698008856914 176 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_599 1935-0052 86.5 µM 2.19691853064089 0.0205721307777079 no 84 0.0140131325813087 173 9557311
SGTC_1474 0330-0125 5.35 µM 2.18933183714893 0.0209395607848896 no 85 0.0142863649779694 142 X1474
SGTC_1070 indatraline 8.81 µM 2.18725255169457 0.0210412267994044 no 86 0.014362046222354 167 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_491 tetrandrine 80.3 µM 2.17655468144144 0.0215709219426669 no 87 0.0147569047972193 116 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3089 9117425 49.47 µM 2.17374146087293 0.0217120728089468 no 88 0.0148622785254559 201 9401657
SGTC_3220 9131269 49.47 µM 2.15536408645859 0.0226534670960057 no 89 0.0155666772072257 119 17722206
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.14918675939743 0.0229775339009829 no 90 0.0158097992221782 188 5282309
SGTC_1386 3228-0095 33.8 µM 2.12839058988792 0.0240973537251168 no 91 0.0166523563509974 157 870181
SGTC_3038 9091290 49.47 µM 2.12108326809387 0.0245015665381778 no 92 0.0169573978675994 187 25236843
SGTC_2389 9091542 195.52 µM 2.109269575396 0.0251670850679644 no 93 0.0174606596900584 214 3626624 YOL127W RPL25
SGTC_1917 st066507 28.5 µM 2.10030107099284 0.0256823798175707 no 94 0.0178511825634036 242 3156428
SGTC_831 k061-1017 217 µM 2.09856914417816 0.0257829001412504 no 95 0.0179274493726734 338 1240153
SGTC_209 4077-0173 175.592 µM 2.09719201920145 0.0258630627183326 no 96 0.0179882903494913 106 15993494
SGTC_1605 st000082 49.1 µM 2.09430229018991 0.0260319521998847 no 97 0.0181165302314625 180 1114022
SGTC_1657 st012939 43.4 µM 2.09151395071727 0.0261957895226339 no 98 0.0182410085917741 154 24207257
SGTC_1696 st025591 34.7925 µM 2.08194083955125 0.0267648617405381 no 99 0.0186739369206975 226 2787147
SGTC_596 1155-0152 116 µM 2.0771416128401 0.0270540138097423 no 100 0.0188942454310101 258 280313
SGTC_1300 1094-0077 113 µM 2.06406632957588 0.0278550487875929 no 101 0.0195057139270172 180 5532636
SGTC_1674 st016616 23.6 µM 2.06073277507992 0.0280624049669496 no 102 0.0196642704983266 219 625830
SGTC_2646 retinol 96.75 µM 2.04898356369794 0.0288035125054395 no 103 0.0202318610813411 177 445354 A vitamin A analog and teratogen.
SGTC_2340 7987427 183.45 µM 2.02803975481168 0.0301649302636915 no 104 0.0212780953735849 221 2239331
SGTC_106 0092-0003 11.579 µM 2.01560429382547 0.03099822143025 no 105 0.0219206852165042 153 1072148
SGTC_1484 3473-2379 286 µM 2.01342835613905 0.031145969718635 no 106 0.0220347924931515 223 671917
SGTC_3196 9111891 49.47 µM 2.00743026009585 0.0315562650220699 no 107 0.0223519347385463 178 18891510
SGTC_2146 5545642 200 µM 2.00538199001519 0.0316973946214633 no 108 0.022461112793283 175 825326
SGTC_2040 5100729 123 µM 2.00030033534691 0.0320497832101453 no 109 0.0227339214218466 244 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_350 k064-0020 19.8 µM 1.99549164926539 0.0323862153792701 no 110 0.0229946420158744 254 2790705
SGTC_2943 9068529 45.32 µM 1.98072830072059 0.0334373592431813 no 111 0.0238108756109757 239 3270634
SGTC_2058 5236698 133 µM 1.96980438814721 0.0342330869765844 no 112 0.0244303967405328 232 766665
SGTC_397 arbidol 50 µM 1.96387370072357 0.0346715730544852 no 113 0.0247723702121174 238 131410 A RNA synthesis inhibitor.
SGTC_1325 1431-0015 227 µM 1.9596320384265 0.0349880016633788 no 114 0.025019406925834 210 1103340
SGTC_3109 9122853 49.47 µM 1.95911815531046 0.0350264978799229 no 115 0.0250494755412869 191 1234709
SGTC_1342 1486-1464 234 µM 1.94511563153119 0.0360889094425302 no 116 0.0258805314810192 228 3253938
SGTC_2653 dihydrofissinolide 100 µM 1.94507247496865 0.0360922241973791 no 117 0.0258831280748512 170 6857746
SGTC_3288 9119690 36.221 µM 1.94267794563685 0.0362765334687574 no 118 0.0260275412818355 208 17595618 YKL019W RAM2
SGTC_2029 5175081 200 µM 1.94115990006485 0.036393777475811 no 119 0.0261194426723507 261 1380876
SGTC_2368 9071271 200 µM 1.93161762216637 0.0371378813751221 no 120 0.0267033595797632 260 27209959
SGTC_3355 9151058 44.0485 µM 1.92829558303581 0.0373998326098734 no 121 0.0269091854549089 224 17015728
SGTC_1910 st062352 60.4 µM 1.92769937295369 0.0374470046430829 no 122 0.0269462650737476 281 2245730
SGTC_3115 9123671 49.47 µM 1.92247954241873 0.0378620750102712 no 123 0.0272727226627903 174 3286988
SGTC_2353 9059630 146.67 µM 1.91928445683889 0.0381179888914366 no 124 0.0274741720026471 191 4779114
SGTC_744 1594-0068 283 µM 1.91582267766759 0.0383968544657141 no 125 0.0276938350807097 297 668392
SGTC_1738 st035555 74 µM 1.90389761675376 0.0393702411561303 no 126 0.0284617597850293 280 5331140
SGTC_2673 kobusone 100 µM 1.90317795722028 0.0394296201877146 no 127 0.028508664194996 158 6710676 An epoxy ketone and protein crosslinker.
SGTC_536 3852-0578 10.6 µM 1.90126491577072 0.0395878193516876 no 128 0.0286336610161061 232 2869208
SGTC_1661 st013063 9.66 µM 1.89454942958374 0.0401472482522955 no 129 0.0290760599532082 272 721395
SGTC_2556 citropten 84.59 µM 1.87790374517472 0.0415616256882718 no 130 0.0301971669813194 295 2775 A potential DNA crosslinker.
SGTC_2157 5649910 96.377 µM 1.86686041027293 0.0425220555194702 no 131 0.0309605418549866 277 2858091
SGTC_3352 9151559 45.5865 µM 1.86666921468483 0.042538840379831 no 132 0.0309738976845852 246 17159339
SGTC_2214 7179297 48.276 µM 1.85845000929284 0.0432654762313743 no 133 0.0315525680963667 188 769744
SGTC_3035 9091303 49.47 µM 1.85586521057006 0.043496051416114 no 134 0.0317363864156998 191 25237002
SGTC_2001 4023502 57.655 µM 1.85252787297818 0.0437952222830447 no 135 0.031975029444103 287 108941 YCR052W RSC6
SGTC_890 0929-0006 47.2 µM 1.8469767450757 0.0442965202919754 no 136 0.0323752553631917 231 1378169
SGTC_1633 st005664 67.9 µM 1.84689751536717 0.0443037085136394 no 137 0.0323809974598907 300 2063822
SGTC_399 oxolinic acid 75 µM 1.84503189458935 0.0444732413264044 no 138 0.0325164495641005 229 4628 A DNA gyrase inhibitor.
SGTC_877 0771-0151 33.1 µM 1.83958158666613 0.0449715176818341 no 139 0.0329148448736882 271 6166523
SGTC_681 1642-0006 26.6 µM 1.83439636539555 0.0454497210363605 no 140 0.0332975893767592 192 4446530
SGTC_1222 0366-0074 1.18 µM 1.83377492089882 0.0455073067239109 no 141 0.0333437059795868 266 286520
SGTC_2314 7727897 200 µM 1.83225834914004 0.0456480850205468 no 142 0.0334564696645612 253 900724
SGTC_1777 st045864 34.765 µM 1.82885838429717 0.0459649647457443 no 143 0.0337104129616733 256 4691462
SGTC_3321 9137793 26.8275 µM 1.82773154488983 0.0460703762619849 no 144 0.0337949257074125 321 4904192
SGTC_2319 6033012 152.6 µM 1.82457670723549 0.0463665324034771 no 145 0.0340324655353578 225 847246
SGTC_893 0958-0369 48.9 µM 1.82450824074688 0.0463729765079967 no 146 0.0340376358226484 318 6819948
SGTC_2267 7931562 200 µM 1.82211701420663 0.046598491531353 no 147 0.0342186163174405 249 934880
SGTC_2026 5148700 152 µM 1.81879069654749 0.0469136570562191 no 148 0.0344716841528368 265 79838
SGTC_1159 4092-0538 61.2 µM 1.81596304887418 0.0471829163554643 no 149 0.0346880202750209 302 717301
SGTC_2471 5466956 24.79 µM 1.81382567820765 0.0473872658280973 no 150 0.0348522839350693 223 724419
SGTC_802 4112-3352 742 µM 1.81107490650119 0.047651304265649 no 151 0.0350646286414925 311 704594
SGTC_2419 paclitaxel 166.5 µM 1.81013298771798 0.0477419866060648 no 152 0.0351375832376962 366 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3097 9117246 49.47 µM 1.79955330395067 0.0487700565983962 no 153 0.0359656000175158 291 16423892
SGTC_1550 gossypolone 36.6 µM 1.79794605312992 0.0489277763884341 no 154 0.0360927785590526 318 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_229 benomyl 22.8748 µM 1.79102181219316 0.0496119184867257 no 155 0.0366448974044762 303 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2433 5607874 27.82 µM 1.78933942466036 0.049779292400352 no 156 0.036780084216887 313 2252428
SGTC_2403 6032726 181.2 µM 1.78407150928932 0.0503062909608396 no 157 0.0372060230649823 308 2881040
SGTC_314 1671-0008 2.74 µM 1.78243083413808 0.0504713279777976 no 158 0.0373395005022432 347 3913060
SGTC_3099 9120367 49.47 µM 1.78081521562256 0.0506342657808484 no 159 0.0374713214500752 266 24824940
SGTC_1692 fluoroquinolonic acid 71 µM 1.76947106768763 0.0517901711398699 no 160 0.0384076474478103 248 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3108 9121785 49.47 µM 1.76069909800698 0.0526982859356916 no 161 0.0391446727535461 298 17140271
SGTC_1480 1070-0044 41.2 µM 1.76067679362098 0.0527006109894906 no 162 0.0391465613497173 299 3124987
SGTC_1073 triclabendazole 3.09 µM 1.75921965282066 0.0528526826996068 no 163 0.0392701037249872 353 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3175 9106517 49.47 µM 1.75794493695752 0.0529860012481753 no 164 0.0393784393822237 260 41468073
SGTC_1100 amiodarone 5.07 µM 1.75539365963357 0.0532536323541118 no 165 0.0395959979181058 319 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_191 3914-0123 66.505 µM 1.75431007845964 0.0533676246280986 no 166 0.0396886948860531 167 3144412
SGTC_472 calcifediol 10 µM 1.75320544994594 0.0534840300371784 no 167 0.0397833739402665 225 5283731 A vitamin D metabolite.
SGTC_2580 diallyl disulphide 81.36 µM 1.75129638129321 0.0536856812970925 no 168 0.0399474353703381 298 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1902 st060212 70.5 µM 1.75046486504037 0.0537737008203149 no 169 0.0400190658654635 302 688944
SGTC_552 k242-0005 476 µM 1.74860525599266 0.0539709619156141 no 170 0.0401796385743676 257 4088318
SGTC_211 3455-0679 143.504 µM 1.74743537602459 0.0540953521248841 no 171 0.040280922782048 332 748649
SGTC_3102 9121669 49.47 µM 1.74282339456555 0.0545879436400143 no 172 0.0406822342505114 245 41905072
SGTC_821 1114-0266 29.2 µM 1.74028110963169 0.054860989895329 no 173 0.0409048346930267 293 3123235
SGTC_160 3453-0671 289.699 µM 1.7388062040083 0.0550198916767308 no 174 0.0410344284830168 338 5322268
SGTC_677 0929-0063 136 µM 1.73454703681602 0.055480803170072 no 175 0.0414105337516858 231 1539583
SGTC_668 1682-0499 62.6 µM 1.73393304883674 0.0555474973679566 no 176 0.041464981559361 362 682214
SGTC_1864 st057645 30.4 µM 1.73183635352686 0.055775727235185 no 177 0.041651351730267 250 688666
SGTC_2926 9010726 65.15 µM 1.72773863612988 0.0562239083850775 no 178 0.0420175466785469 333 2994293
SGTC_2871 9038510 12.99 µM 1.72287468899074 0.0567595747235136 no 179 0.0424555942132371 318 4945164
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.71774501076938 0.0573288528862881 no 180 0.042921567746374 272 688803
SGTC_2110 5483698 200 µM 1.71142138908623 0.0580368037727891 no 181 0.0435016757493464 298 2848765 YHR062C RPP1
SGTC_1135 dihydrocapsaicin 536.708 nM 1.70968006344696 0.0582329526649476 no 182 0.0436625256732109 345 107982 A Capsaicinoid.
SGTC_19 0279-0214 38.434 µM 1.7051680930966 0.0587436197209427 no 183 0.0440815394593135 409 3566274 YBR002C RER2
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.7049680795642 0.0587663384534774 no 184 0.0441001889326565 335 2333 A French combination drug.
SGTC_2028 5153890 36.43 µM 1.70408963010601 0.0588661996543538 no 185 0.044182171824842 323 2830968 YPR165W RHO1
SGTC_1121 fusaric acid 630.51 nM 1.70349892325782 0.0589334254235673 no 186 0.0442373696687801 348 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1174 0739-0097 51.1 µM 1.70102977380071 0.0592150808805236 no 187 0.0444686982232475 344 728447
SGTC_1181 1222-0449 220 µM 1.70051288502335 0.0592741757007923 no 188 0.0445172474200513 316 658318
SGTC_5 0352-0601 109.883 µM 1.6923264539477 0.0602162921348542 no 189 0.045291873301138 250 762456
SGTC_1631 benzylvanillin 81.9 µM 1.69000704990717 0.0604853354076429 no 190 0.0455133029540338 359 75506
SGTC_569 4130-2812 160 µM 1.68989305289391 0.0604985828981057 no 191 0.0455242084636212 218 743552
SGTC_2889 9059656 51.95 µM 1.68015512652583 0.0616386213546244 no 192 0.046463568769603 333 3949838
SGTC_47 0149-0135 24.25 µM 1.67827859461327 0.0618602261309208 no 193 0.0466463623840037 310 5239155
SGTC_980 1473-0395 201 µM 1.6749060233147 0.0622600648480173 no 194 0.0469763358248177 274 768876
SGTC_963 1269-2853 151 µM 1.67330221570132 0.0624509117847073 no 195 0.0471339082504679 333 3668223
SGTC_1728 st035614 33.7865 µM 1.67243746749501 0.0625540025999358 no 196 0.0472190445199318 417 15945546
SGTC_9 0092-0002 10.449 µM 1.6666133583177 0.0632517820304264 no 197 0.0477956554704254 334 759368
SGTC_2478 5763493 32.33 µM 1.66547932881559 0.0633883509499901 no 198 0.0479085821610229 323 1365576 YLR208W SEC13
SGTC_1311 1190-0148 100 µM 1.6630927426528 0.0636765125019934 no 199 0.0481469361989073 415 1961333
SGTC_2940 9060638 45.86 µM 1.66251077855271 0.0637469344291957 no 200 0.0482052020050845 363 4027022
SGTC_2287 7945887 168.79 µM 1.65980853812134 0.0640747194094302 no 201 0.0484764877824224 334 1245853
SGTC_20 0481-0013 4.944 µM 1.65917532516921 0.0641517180751813 no 202 0.0485402341079333 341 182045
SGTC_2683 piperine 63.03 µM 1.65693245374017 0.064425029839765 no 203 0.0487665660507373 291 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_15 0266-0086 27.098 µM 1.65610451032339 0.0645261496696627 no 204 0.0488503280630295 436 1712902 YIL048W NEO1
SGTC_1478 0453-0656 35.7 µM 1.65448053277724 0.0647248501839119 no 205 0.0490149577592474 351 5258496
SGTC_645 0845-0943 5.41 µM 1.65409855444135 0.0647716558020578 no 206 0.0490537448867022 326 1885106
SGTC_343 4130-2827 29.8 µM 1.65006641000897 0.0652673379849904 no 207 0.0494646769911718 362 1118244
SGTC_1588 farnesol 29.9 µM 1.64878722897636 0.0654252044973191 no 208 0.0495956161136846 351 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1052 3253-3998 198 µM 1.64177994368984 0.0662952489569254 no 209 0.0503178084963571 395 5450317
SGTC_1361 1608-0041 5.61 µM 1.6392498021819 0.0666115909963896 no 210 0.0505806228507001 356 X1361
SGTC_2755 lomerizine 42.69 µM 1.63905856800517 0.0666355482969044 no 211 0.0506005313547843 376 3949 A calcium channel blocker.
SGTC_2465 5809242 33.21 µM 1.63895381370569 0.0666486744589823 no 212 0.0506114394852317 270 2731748
SGTC_1077 5-fluorocytosine 377 nM 1.6366144220902 0.0669423318862855 no 213 0.0508555301231444 330 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2072 5231554 129 µM 1.63591103399273 0.0670308216935635 no 214 0.0509291041775741 326 789545
SGTC_3207 9114163 49.47 µM 1.63499623529201 0.067146043341931 no 215 0.0510249184132227 407 849233
SGTC_126 0417-1624 672.48 µM 1.63071321113831 0.0676875412572226 no 216 0.0514754238223092 440 41912 YDL195W SEC31
SGTC_2895 9054447 58.44 µM 1.62945009991657 0.067847877440469 no 217 0.0516088851365855 312 2697450
SGTC_686 1319-0111 510 µM 1.62907420229617 0.0678956495362906 no 218 0.0516486558468421 370 4562600
SGTC_1292 0kpi-0043 232 µM 1.62161181772515 0.0688494151291586 no 219 0.0524432453362147 349 3333905
SGTC_3121 9125696 49.47 µM 1.61735451761615 0.0693981483110499 no 220 0.0529008887407749 287 1235365
SGTC_2235 salicylic acid 500 µM 1.6143897538677 0.0697822688967034 no 221 0.0532214563827292 289 338 A COX inhibitor and kinase inhibitor.
SGTC_523 1934-0222 13.7 µM 1.6108078057376 0.0702485335780561 no 222 0.0536108096259806 380 1361595
SGTC_231 b-estradiol 524 µM 1.61075336874003 0.0702556381179227 no 223 0.0536167442189362 289 450 A steroid.
SGTC_3254 9136651 49.47 µM 1.60974625658921 0.0703871754180373 no 224 0.0537266311087416 395 16454030
SGTC_3023 9089636 49.47 µM 1.60664811785242 0.0707930056742979 no 225 0.0540657903744455 347 17249241
SGTC_3093 9117344 49.47 µM 1.59296980335812 0.0726062698815274 no 226 0.0555834826828086 357 24824913
SGTC_746 1095-0025 46.6 µM 1.59257747598825 0.0726587986407797 no 227 0.0556275048876241 387 6749286
SGTC_2063 5246145 200 µM 1.58782403669935 0.073297551815507 no 228 0.05616306727126 397 711240
SGTC_2367 9070478 135.38 µM 1.58486736062328 0.0736970227378078 no 229 0.056498236863899 406 572802
SGTC_1372 2752-0194 270 µM 1.58296829678333 0.0739544780870838 no 230 0.0567143452733518 352 823334
SGTC_2138 5575593 77.673 µM 1.58151467942483 0.0741520083355755 no 231 0.0568802026089224 299 762213
SGTC_2694 st077685 81.9 µM 1.58145728269188 0.0741598161683514 no 232 0.056886759390683 380 2838096
SGTC_1416 3966-0321 25.3 µM 1.57686275492273 0.0747868614408442 no 233 0.0574135540632872 384 582530 YLR208W SEC13
SGTC_2070 5230947 200 µM 1.57646700225301 0.0748410610552452 no 234 0.0574591088111116 378 2835538
SGTC_1574 spiramycin 23.7 µM 1.57632620090039 0.0748603514838996 no 235 0.0574753231893736 404 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1931 st074438 57.1 µM 1.57421979486769 0.0751493917641247 no 236 0.0577183222806944 361 2787313
SGTC_838 0109-0203 71.4 µM 1.57378759754193 0.0752088028007696 no 237 0.057768281143206 379 759422
SGTC_2306 7482397 179.52 µM 1.56918830553197 0.0758432541624674 no 238 0.0583020341676377 373 891448
SGTC_792 4534-1957 155 µM 1.5677583496225 0.0760413384222644 no 239 0.0584687692453444 351 1717904
SGTC_572 0960-0087 17.7 µM 1.56590216467679 0.0762990531048631 no 240 0.0586857615095672 455 6796365
SGTC_1526 st051518 75 µM 1.56407871420542 0.0765528695535147 no 241 0.0588995420503306 351 673993
SGTC_2203 7227154 166.4 µM 1.56052373411412 0.0770495533604035 no 242 0.0593180828644708 344 896304
SGTC_260 nsc-65238 3.989 µM 1.56005990098519 0.07711453798134 no 243 0.0593728631870973 350 3246252
SGTC_1481 3346-2004 36 µM 1.55488350541817 0.0778425974206678 no 244 0.0599869082157202 399 2770522
SGTC_2149 5554786 194.827 µM 1.54224299037938 0.0796423960210985 no 245 0.0615072783925445 447 745063 YPR165W RHO1
SGTC_981 1488-1094 54.9 µM 1.53787954160253 0.0802709336921851 no 246 0.062039035186762 347 3449522
SGTC_50 0929-0078 56.389 µM 1.53461759138734 0.0807432482358097 no 247 0.0624388944973688 399 1377751
SGTC_928 2764-0428 58.7 µM 1.52482011616596 0.0821744925758239 no 248 0.0636519855153693 443 662578
SGTC_411 enrofloxacin 100 µM 1.52406665037088 0.0822853474369761 no 249 0.0637460312597305 378 71188 A bacterial gyrase inhibitor.
SGTC_2701 st077767 14.721 µM 1.5224741117953 0.0825200227509011 no 250 0.063945163651704 466 5721188
SGTC_989 1501-0895 10.3 µM 1.51934124868764 0.0829831490799184 no 251 0.0643383110159451 380 2830112
SGTC_2779 methotrexate 400 µM 1.5191553100464 0.0830106974402658 no 252 0.0643617036347057 417 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2092 5303694 80.6725 µM 1.51910394488278 0.0830183088300621 no 253 0.0643681669620016 439 1963699
SGTC_1905 st060207 84.5 µM 1.51877763500763 0.0830666743216508 no 254 0.0644092386233211 392 1948547
SGTC_2882 9058044 58.44 µM 1.51702608055566 0.0833266510995076 no 255 0.0646300497132965 387 18076804
SGTC_1145 3546-0597 10.2 µM 1.51091206080318 0.0842389271520717 no 256 0.0654054287884206 440 875334
SGTC_98 0074-0023 107.663 µM 1.50995257949244 0.084382769776519 no 257 0.0655277623537986 442 3563821
SGTC_1889 st059080 5.18 µM 1.50887763954315 0.0845441404373809 no 258 0.06566502752617 443 176925 Isolated from Daphnopsis sellowiana.
SGTC_818 4072-2707 53.5 µM 1.50879721722849 0.0845562227870563 no 259 0.065675306063407 359 882871
SGTC_3192 9110362 49.47 µM 1.5043512288257 0.0852261884276246 no 260 0.0662454774842353 421 16649480
SGTC_444 curcumin 90.4 µM 1.50407595041801 0.0852678004917042 no 261 0.066280905934825 438 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.50314363895939 0.0854088450889696 no 262 0.0664010038352491 473 6708784 An antioxidant flavonoid
SGTC_2781 5567276 71.43 µM 1.50050014266404 0.0858097161842523 no 263 0.0667424482885547 432 2853274
SGTC_2696 st077691 74.316 µM 1.49666068177296 0.0863944542894924 no 264 0.0672407859333093 397 757133
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.49505672454171 0.0866396124693309 no 265 0.0674498193429261 430 115019
SGTC_2598 perillyl alcohol 100 µM 1.49246537973708 0.0870367867759008 no 266 0.0677885932758491 438 10819 An apoptosis inducer.
SGTC_1879 gemcitabine 100 µM 1.48740109550632 0.0878169106779777 no 267 0.068454453872365 418 60750 A nucleoside analog which inhibits DNA replication.
SGTC_618 k072-0232 33.2 µM 1.4869105887409 0.0878927465921134 no 268 0.0685192136245005 396 5872756 YGL099W LSG1
SGTC_1649 st011737 51.3 µM 1.48346114345282 0.0884274359067218 no 269 0.0689759663887332 420 1761035
SGTC_2864 9034755 47.6 µM 1.48194631566183 0.0886630097217537 no 270 0.0691772899655811 420 4930451
SGTC_1376 2910-0861 41.3 µM 1.47917390546677 0.0890953626556939 no 271 0.0695469209081903 451 1112859
SGTC_1226 3909-7979 35.4 µM 1.478055580522 0.0892702070680796 no 272 0.0696964510528869 487 6615510
SGTC_620 0109-0052 432 µM 1.47689186476043 0.0894524190106532 no 273 0.069852312996779 433 493037
SGTC_136 0097-0015 404.482 µM 1.4717745077703 0.0902569666353424 no 274 0.0705408898576849 477 4861337
SGTC_1822 st052468 42 µM 1.47166188854306 0.0902747328038027 no 275 0.0705561020418741 410 2873678
SGTC_300 r073-0011 5.04 µM 1.46977331631565 0.0905730503118491 no 276 0.0708115791716303 499 2735780
SGTC_806 3966-4455 5.86 µM 1.46471604622374 0.0913754957281605 no 277 0.0714992025872864 383 714982
SGTC_1857 st056007 79.3 µM 1.46404826101331 0.0914818469820294 no 278 0.0715903812148472 385 619834
SGTC_2168 5727979 200 µM 1.46270684219917 0.0916957580922685 no 279 0.0717738065647889 408 695210
SGTC_2467 5474540 200 µM 1.46188373638123 0.0918271990721948 no 280 0.0718865362188903 452 5413519
SGTC_706 4262-0057 46.9 µM 1.46170947949098 0.0918550438798346 no 281 0.071910419230573 436 883298
SGTC_2972 9093619 59.92 µM 1.45957743744049 0.0921962330316059 no 282 0.0722031219643993 438 25236256
SGTC_1749 st037932 54.2 µM 1.4580138951555 0.0924470411923009 no 283 0.0724183565233498 440 594497
SGTC_2067 5224629 34.075 µM 1.45755506073552 0.0925207386473794 no 284 0.0724816120871395 460 2835000
SGTC_701 4424-0219 185 µM 1.45576002343977 0.0928094731206319 no 285 0.0727294852309091 501 2911779
SGTC_1852 st056254 31.4 µM 1.45450126297051 0.0930123437325206 no 286 0.0729036917884314 435 442583
SGTC_786 4544-0069 423 µM 1.45344879988914 0.0931822174802309 no 287 0.0730495927885112 466 748821 YLR208W SEC13
SGTC_2300 7976697 71.57 µM 1.45091042749542 0.0935928688517763 no 288 0.0734024019578613 377 2236109
SGTC_908 3448-7491 47.7 µM 1.4502706039374 0.0936965884275827 no 289 0.0734915365511252 564 1203031
SGTC_1476 4112-3294 3.34 µM 1.44977234391718 0.0937774183867642 no 290 0.0735610070656064 425 704369
SGTC_996 3970-0799 1.8 µM 1.44459986690177 0.0946195633591079 no 291 0.074285155101458 605 6615648 YGL040C HEM2
SGTC_2726 cimetidine 79.27 µM 1.43952598578945 0.0954510590759447 no 292 0.0750007764556498 373 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_208 k072-0098 12.366 µM 1.43904993651197 0.095529348034001 no 293 0.0750681874369764 548 5948901
SGTC_904 1141-0088 396 µM 1.43628706064199 0.0959846515888854 no 294 0.0754603372129316 452 1378119
SGTC_3319 9138450 16.7555 µM 1.43563683590651 0.0960920358909154 no 295 0.0755528536361516 438 2029690
SGTC_957 1187-1561 14.1 µM 1.4353759900074 0.0961351392813091 no 296 0.0755899920536929 479 1538454
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.43333919801363 0.0964721971938963 no 297 0.075880462574242 420 2346 DNA damaging agent; causes G2/M arrest.
SGTC_79 0052-0007 94.094 µM 1.43231273891634 0.0966423891602421 no 298 0.0760271694823345 459 2801472
SGTC_312 4092-0653 6.84 µM 1.43215854918302 0.0966679736168777 no 299 0.0760492257294219 568 1148278
SGTC_679 0422-0091 41.4 µM 1.4265852905613 0.097596078075783 no 300 0.0768497332816833 505 627384 YHR062C RPP1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.42446099812494 0.0979515471340924 no 301 0.0771565337506651 512 5379071
SGTC_2090 5301565 104.445 µM 1.42422027831172 0.0979918878246004 no 302 0.0771913582798057 527 2056344
SGTC_2511 berberine 10.47 µM 1.42307574615184 0.0981838591977726 no 303 0.0773570992136786 441 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_988 1497-1057 103 µM 1.41688136099151 0.099227619939674 no 304 0.0782588084257489 463 3533044
SGTC_2047 4141938 200 µM 1.41518875488175 0.0995142322888133 no 305 0.0785065803446248 398 3807862
SGTC_2985 9022375 71.43 µM 1.41104290988817 0.100218811462655 no 306 0.0791159809793974 488 4939335
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.40587681493987 0.101101867328372 no 307 0.0798803535450556 445 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2561 acetosyringone 100 µM 1.40367756531323 0.101479507596648 no 308 0.0802074429975052 542 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_669 0108-0021 26.2 µM 1.4005357853614 0.102020773460425 no 309 0.0806764675329584 599 17201
SGTC_689 0833-0039 98 µM 1.39926138244508 0.102240925441622 no 310 0.0808673077572852 489 5374726
SGTC_872 0588-0139 234 µM 1.39915394792806 0.102259500440976 no 311 0.0808834115036764 511 2047100
SGTC_2897 9048598 12.99 µM 1.39754514432198 0.102537949809548 no 312 0.0811248505205742 452 6467404
SGTC_177 1327-0068 8.361 µM 1.39652855568606 0.102714183443753 no 313 0.0812776938420516 500 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1015 4130-4525 82 µM 1.39352352721604 0.103236415675071 no 314 0.0817307677732748 494 1363237
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.39230450626742 0.103448813361932 no 315 0.0819151037605774 473 5282362
SGTC_623 k072-0108 16.9 µM 1.39045686882085 0.103771343266678 no 316 0.0821950939422568 495 5382803
SGTC_2064 5220758 200 µM 1.38534948527373 0.104666699463955 no 317 0.0829728145822879 532 788518
SGTC_1988 st071872 53.4 µM 1.3824245704686 0.10518196820674 no 318 0.0834206880582709 454 16414116
SGTC_1839 st053978 48 µM 1.37704521745591 0.106134411601285 no 319 0.0842491341402136 483 3788398
SGTC_184 1494-0393 24.714 µM 1.3743435206673 0.106615105166944 no 320 0.0846675306347867 517 3090647
SGTC_782 0083-0095 30.5 µM 1.37277394867814 0.106895088519263 no 321 0.0849113159547557 547 3591729 An indicator and reagent.
SGTC_2383 9036125 200 µM 1.3723748271272 0.106966369129419 no 322 0.0849733911984342 436 79580
SGTC_2962 9082311 13.18 µM 1.37218275467758 0.107000684284414 no 323 0.0850032762847571 464 16459453
SGTC_383 2324-0395 7.37 µM 1.37211141014874 0.107013432531253 no 324 0.0850143789847304 516 3146421
SGTC_1128 3448-9350 235 µM 1.37208844007608 0.107017537187822 no 325 0.0850179538394749 443 619386
SGTC_2202 7226349 200 µM 1.36978419146632 0.107429874111588 no 326 0.0853771391318007 424 844334
SGTC_776 4476-4378 112 µM 1.36690731550634 0.107946286357221 no 327 0.0858271793557622 462 2892008
SGTC_524 r073-0010 27.8 µM 1.3668383147367 0.10795869422116 no 328 0.0858379951606439 485 2772106
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.36609667305606 0.108092122640096 no 329 0.0859543112038857 540 5106787 A p450 inhibitor.
SGTC_3243 9134147 49.47 µM 1.36451732067528 0.108376658730509 no 330 0.0862024033205027 488 24282180
SGTC_1979 st071809 45.3 µM 1.36299800114983 0.108650887542727 no 331 0.0864415702848498 488 4976333
SGTC_2170 morpholine 200 µM 1.36070551026348 0.109065613598968 no 332 0.086803386279449 483 121171 Reacts with secondary amines.
SGTC_2332 7982454 138.89 µM 1.36047480090313 0.109107413301626 no 333 0.0868398609266128 521 2981748
SGTC_1107 amlodipine 47 µM 1.3598804522198 0.109215149860262 no 334 0.0869338789072672 514 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_428 3448-4153 16.5 µM 1.3597503926193 0.109238735729161 no 335 0.0869544627263682 449 3834874
SGTC_1036 k216-0215 33.5 µM 1.35806064740641 0.109545497995142 no 336 0.0872222204341923 565 622330
SGTC_531 3788-1495 174 µM 1.349595815359 0.111091545672036 no 337 0.0885728336021515 500 2896655
SGTC_305 1682-2595 20.8 µM 1.34794270367434 0.111395290897323 no 338 0.0888384058603863 529 226033
SGTC_940 3232-1287 54.8 µM 1.34663011782768 0.111636890412173 no 339 0.0890496945907266 521 1585493 YIL048W NEO1
SGTC_1745 st081495 74 µM 1.34609016439449 0.111736385031939 no 340 0.0891367201241212 575 13842402 YBL026W LSM2
SGTC_2858 9025781 8.96 µM 1.34436366922914 0.112054943594002 no 341 0.0894154080345366 645 4894980 YPL153C RAD53
SGTC_1512 0259-0544 12.2 µM 1.34332189823636 0.112247476340688 no 342 0.0895838821652526 560 18476
SGTC_1333 1482-0047 286 µM 1.3393144869689 0.112990301384605 no 343 0.0902341572607792 556 3811116
SGTC_2037 5169046 200 µM 1.3383242847569 0.113174387406511 no 344 0.0903953743766039 482 5718022
SGTC_2016 5121758 140 µM 1.33517849794318 0.113760632270557 no 345 0.0909089662694069 579 2795203
SGTC_369 0957-0393 4.5 µM 1.33513662326103 0.113768450553887 no 346 0.0909158174433138 484 6997992
SGTC_2684 capsaicin 100 µM 1.32802015111676 0.115102711124074 no 347 0.092085724977207 492 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1327 1436-0082 2.18 µM 1.32590672774981 0.115501089164206 no 348 0.0924352971292941 515 15992205
SGTC_998 3996-0085 177 µM 1.3218655153758 0.116265579013548 no 349 0.0931064686783313 589 715391
SGTC_2132 5317594 122.667 µM 1.32137322220087 0.116358952548041 no 350 0.093188475055894 465 794577
SGTC_366 0181-0206 4.31 µM 1.3172583574468 0.11714150254473 no 351 0.0938760192835797 561 274874
SGTC_264 promethazine 12.5 mM 1.31318559425973 0.117919710174673 no 352 0.0945602085003912 664 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2793 7325131 81.82 µM 1.30931813797492 0.118662067600079 no 353 0.0952133040653246 490 4176441
SGTC_1838 st055369 84.5 µM 1.30678948278787 0.119149224151545 no 354 0.0956421090200591 488 676036
SGTC_162 k030-0015 37.8 µM 1.30568573009872 0.119362308994906 no 355 0.0958297263386136 533 1809920 YMR134W ERG29
SGTC_2468 5987765 72.9 µM 1.30518827355289 0.11945843326663 no 356 0.0959143730957616 553 26772094
SGTC_947 3447-0010 211 µM 1.30464768501712 0.119562953906966 no 357 0.0960064214875213 518 748350
SGTC_2681 menadione 3.18 µM 1.30340219663087 0.119804009608584 no 358 0.0962187434893755 540 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3273 9137859 49.47 µM 1.30167254340006 0.120139340161053 no 359 0.0965141746870856 490 2377234
SGTC_1199 1638-0010 4.46 µM 1.30010097251538 0.120444596048025 no 360 0.0967831822034605 579 3111136
SGTC_117 lucigenin 22.078 µM 1.29631222412983 0.121182752646723 no 361 0.0974339693943119 611 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_709 3807-1509 243 µM 1.29418954117209 0.121597699989325 no 362 0.0977999792580564 518 1886677 YPL242C IQG1
SGTC_897 1000-0139 31.4 µM 1.28990628100378 0.122438040447847 no 363 0.0985415998615855 539 6151020
SGTC_1127 asiatic acid 681.4 nM 1.28807037421474 0.122799475204425 no 364 0.0988607334880253 546 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_438 sphingosine 6.67 µM 1.28335294747821 0.12373162392249 no 365 0.0996842252796496 463 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2565 isoliquiritigenin 100 µM 1.28316536945354 0.123768790883202 no 366 0.0997170729007167 449 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1756 st041558 35.5 µM 1.28223405720741 0.123953438071729 no 367 0.0998802762266425 606 3955792
SGTC_1594 piperine 70.1 µM 1.28047096103965 0.124303527164762 no 368 0.100189775626273 571 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1429 4049-0205 9.46 µM 1.27796702761177 0.124801908126414 no 369 0.100630526216703 595 22774478
SGTC_1163 k060-0048 49.9 µM 1.27646081951766 0.125102374324551 no 370 0.10089633425792 597 6809982
SGTC_1710 st031758 61.5 µM 1.27645038578626 0.125104457459809 no 371 0.100898177334032 530 5394341
SGTC_1578 josamycin 24.2 µM 1.27639773242842 0.125114970278109 no 372 0.100907478709517 515 5282165 A P450 substrate.
SGTC_2811 7967822 32.47 µM 1.27632054764533 0.125130382178602 no 373 0.100921114765599 568 2232244
SGTC_1898 st060199 18.6 µM 1.27553623125921 0.125287066034788 no 374 0.101059754308456 524 688866
SGTC_1059 3448-6867 171 µM 1.27286657916432 0.125821412128303 no 375 0.101532695231762 560 3934407
SGTC_2512 diallyl trisulfide 49.23 µM 1.2717330761267 0.126048769272086 no 376 0.101733987158055 521 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2571 chrysanthemic acid 100 µM 1.27125507235886 0.126144732701394 no 377 0.101818959982862 529 2743 An insecticide.
SGTC_1 0258-0098 57.368 µM 1.26815417582393 0.126768501542671 no 378 0.102371448886519 491 6790032 YDR047W HEM12
SGTC_2618 avocadyne 43.43 µM 1.26649448244419 0.127103242383663 no 379 0.102668051787975 544 3015189
SGTC_854 0422-0053 192 µM 1.26639662884555 0.127122997499024 no 380 0.102685558629777 560 3596728
SGTC_2051 5263410 176 µM 1.26573718422533 0.127256184797662 no 381 0.10280359546847 586 227584
SGTC_2093 5331342 194.4 µM 1.26133860610275 0.128147043927336 no 382 0.103593438755668 582 33839
SGTC_490 phenamil 164 µM 1.2609592317188 0.128224082329566 no 383 0.103661767922159 441 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2591 skatole 100 µM 1.25688253023241 0.129053955672578 no 384 0.104398087667312 552 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3333 9141820 12.094 µM 1.25608867905834 0.129215988154943 no 385 0.104541910102559 518 1939433
SGTC_1461 k072-0203 53.8 µM 1.2557675292541 0.129281577894538 no 386 0.104600133742802 558 5418714
SGTC_1093 fluphenazine 7.97 µM 1.25449190805189 0.129542331081191 no 387 0.104831632558292 610 6602611 An atypical antipsychotic.
SGTC_1867 st057372 64 µM 1.25393945270546 0.129655372965636 no 388 0.104932006797909 579 688837
SGTC_2706 st078239 82.5 µM 1.25177556492217 0.130098799510991 no 389 0.105325828152492 585 15434492
SGTC_2345 9052315 157.45 µM 1.24907111934799 0.130654471913639 no 390 0.105819531377813 590 6469265
SGTC_873 0591-4978 488 µM 1.24391372728018 0.131718685201865 no 391 0.10676565829057 633 3305145
SGTC_1833 st055984 71 µM 1.24314551906002 0.131877713167249 no 392 0.106907107305662 570 676288
SGTC_2438 5259590 200 µM 1.24293095983274 0.131922153054785 no 393 0.10694663791349 607 1201127
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.24071186340662 0.132382382142221 no 394 0.107356105090232 600 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1897 st060201 15 µM 1.23703388537118 0.133147610154193 no 395 0.108037251450072 556 611878
SGTC_3163 9099914 49.47 µM 1.23422680782267 0.133733685966743 no 396 0.10855920033727 531 16268368
SGTC_1651 st011928 86.1 µM 1.23325088687122 0.133937858514229 no 397 0.108741087644918 601 720198
SGTC_386 1509-0011 3.07 µM 1.23272303768339 0.134048379128963 no 398 0.108839556830456 692 3107280
SGTC_1125 tnp00248 1.32998 µM 1.23154195054099 0.134295901059091 no 399 0.109060118394035 726 24207736
SGTC_3145 9085516 49.47 µM 1.22948686404418 0.134727335983409 no 400 0.109444659973037 570 25236195
SGTC_3072 9116419 49.47 µM 1.2280486075874 0.135029841731662 no 401 0.109714360801388 519 17170162
SGTC_1477 0139-0234 16 µM 1.22584429160486 0.135494374805359 no 402 0.110128637995919 597 620880
SGTC_1280 0880-0253 10.1 µM 1.22544730045744 0.135578152143952 no 403 0.110203367250508 617 6836607
SGTC_2987 9018338 71.43 µM 1.22485455317331 0.135703306088923 no 404 0.110315013146578 613 5055682
SGTC_2979 9012552 45.46 µM 1.21984866324146 0.136763416668119 no 405 0.11126112494309 544 17100905
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.21210618923589 0.138414185128012 no 406 0.112735867426664 544 17037758
SGTC_2265 7929201 200 µM 1.2087928444916 0.139124753736524 no 407 0.113371220660555 601 1265108
SGTC_1784 st039334 36.3 µM 1.2069239809488 0.139526637104935 no 408 0.113730710658617 615 3496984
SGTC_1911 st060208 74.3 µM 1.20531981256663 0.139872229147386 no 409 0.114039931976605 657 688783
SGTC_1257 0669-0121 16 µM 1.20379923396928 0.14020034981575 no 410 0.11433359293092 675 4307855
SGTC_1782 st039423 80.636 µM 1.19984201179201 0.141056715141685 no 411 0.115100352236771 578 2068169
SGTC_2155 5570423 76 µM 1.1997027283379 0.141086921359706 no 412 0.115127406529589 606 797402
SGTC_2062 5245942 200 µM 1.19594939720149 0.141902553223037 no 413 0.11585815339277 656 1376160
SGTC_173 1273-0061 2.693 µM 1.19578894559081 0.141937491784286 no 414 0.115889465421735 648 2847414 YPL266W DIM1
SGTC_717 1532-0246 73.2 µM 1.19518924168775 0.142068129705813 no 415 0.116006550451998 628 9561992
SGTC_3087 9117406 49.47 µM 1.19471560030753 0.142171364004686 no 416 0.11609908261388 601 42546093
SGTC_2154 5570129 200 µM 1.19440120925487 0.142239916322148 no 417 0.116160532020462 655 673366
SGTC_245 methotrexate 289.6 µM 1.19323050493545 0.142495382665693 no 418 0.116389555417734 683 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_469 w7 172 µM 1.19035110581824 0.143125033035155 no 419 0.116954210946507 575 45115570 A P450 inhibitor.
SGTC_2388 9080168 200 µM 1.18884478063208 0.143455175234395 no 420 0.117250376376969 585 15943073
SGTC_210 3551-0445 56.827 µM 1.18732944765262 0.14378781003621 no 421 0.117548848486479 647 2865180 YOR207C RET1
SGTC_123 0083-0120 66.675 µM 1.18718786323331 0.143818916172681 no 422 0.117576763538764 650 16001701
SGTC_703 3875-0075 71.8 µM 1.18595579247367 0.144089794107125 no 423 0.117819879058075 675 2850814
SGTC_2951 9072950 58.06 µM 1.18433517319713 0.144446620259985 no 424 0.118140205378642 676 16488155
SGTC_886 0866-0150 153 µM 1.17929048618055 0.145561162908113 no 425 0.119141262655923 677 271463
SGTC_2643 anethole 100 µM 1.17693205219957 0.146084199592905 no 426 0.119611313837519 670 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2853 9015042 58.44 µM 1.17532840519319 0.146440565236143 no 427 0.119931677259097 588 6457456
SGTC_2256 7954252 200 µM 1.17370320051699 0.14680231641652 no 428 0.120256963932127 536 2972920
SGTC_1363 1636-0063 10.4 µM 1.17252745620436 0.14706439650452 no 429 0.120492677738726 678 6072185
SGTC_2482 5981709 142.65 µM 1.17250949864105 0.14706840177832 no 430 0.120496280400875 674 877755
SGTC_2106 5357045 167.29 µM 1.17159714185852 0.147271991054319 no 431 0.120679418060692 652 668842
SGTC_1328 1441-0025 69.2 µM 1.16810667735945 0.148052619302274 no 432 0.121381868612122 590 4562601
SGTC_3216 9129716 49.47 µM 1.16799698392201 0.148077196594449 no 433 0.121403990742237 593 8056934
SGTC_1468 k284-1086 134 µM 1.16751234475888 0.148185814787537 no 434 0.121501762974476 705 15996457
SGTC_1515 3460-0031 42.1 µM 1.16646734041362 0.148420204386412 no 435 0.121712772897189 558 2876596
SGTC_1638 st008370 60.6 µM 1.16590433634738 0.148546586293687 no 436 0.121826562780319 650 24207134
SGTC_3098 9119039 49.47 µM 1.1656123606314 0.148612156682731 no 437 0.121885604000016 652 17161528
SGTC_712 r015-0009 80.6 µM 1.1635272585186 0.149080980539523 no 438 0.122307822612362 591 6813872 YLR060W FRS1
SGTC_742 0kpi-0133 140 µM 1.1629248047436 0.14921662274402 no 439 0.122430006234444 665 2728852
SGTC_2227 7312221 64.1025 µM 1.16252780047887 0.149306053115779 no 440 0.122510569458223 628 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.16128131162575 0.149587073459438 no 441 0.122763758484995 590 364106
SGTC_1925 st057770 10.1 µM 1.16109726984188 0.149628595480231 no 442 0.122801172448889 591 5989122
SGTC_634 1611-4317 11.2 µM 1.16024263597762 0.149821511836567 no 443 0.122975016259487 715 2843522
SGTC_3331 9141060 1.957 µM 1.15997862357118 0.149881140838459 no 444 0.123028754734588 611 4906567 YPR165W RHO1
SGTC_953 1188-0045 9.7 µM 1.15657737658066 0.150650750992111 no 445 0.123722534850198 668 6144426
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.15655636166386 0.150655514264788 no 446 0.123726829931629 641 616764
SGTC_48 0382-0018 55 µM 1.15432433635798 0.15116199952872 no 447 0.124183611358126 622 762596
SGTC_2432 5630864 12.22 µM 1.15255520001568 0.151564251129956 no 448 0.124546500221088 646 5714970
SGTC_615 k087-0205 167 µM 1.15128565568247 0.151853347774161 no 449 0.124807368206157 633 9642773
SGTC_207 4185-0010 4.486 µM 1.15095021491561 0.151929794441435 no 450 0.124876358829849 750 3761753
SGTC_201 4262-0159 12.803 µM 1.14928851865683 0.152308870576658 no 451 0.125218515395723 582 1341029
SGTC_2728 chlorpromazine 9.18 µM 1.14906946308372 0.152358889649711 no 452 0.1252636694805 549 2726 A thorazine and dopamine antagonist.
SGTC_1462 k081-0014 26.5 µM 1.14808246896807 0.152584394766059 no 453 0.125467260297894 505 3270634
SGTC_2709 st078560 56 µM 1.14597188400978 0.153067356882003 no 454 0.125903392874997 671 17250903
SGTC_2823 7987624 58.44 µM 1.1447243562889 0.153353302817841 no 455 0.126161679360391 683 2239440
SGTC_2813 7971799 71.43 µM 1.14325585334936 0.153690351680863 no 456 0.126466189250646 647 2234054
SGTC_1112 tnp00069 1.16933 µM 1.13997665787491 0.154444757382696 no 457 0.127148012973984 735 145826
SGTC_1225 1216-0074 20.6 µM 1.13880941541808 0.154713880836213 no 458 0.127391326929936 673 4241466
SGTC_2187 6125751 200 µM 1.13877872238284 0.15472096170697 no 459 0.127397729319339 684 874498
SGTC_1648 st011736 69.8 µM 1.1375397015462 0.155006982100752 no 460 0.127656368764603 662 2855514
SGTC_1972 st070201 17.4 µM 1.13660433333401 0.155223137287824 no 461 0.12785186387193 678 2829099
SGTC_2457 5731572 11.68 µM 1.13497042250446 0.155601196511712 no 462 0.12819385565723 682 2865357
SGTC_651 3253-0966 34.4 µM 1.13485475045153 0.155627984062356 no 463 0.128218090884203 700 781462
SGTC_1344 1488-0097 29.1 µM 1.13464655065398 0.155676207025382 no 464 0.128261720236065 651 747966
SGTC_356 1634-0012 32.5 µM 1.13375259315778 0.155883376270517 no 465 0.128449170841404 712 735457
SGTC_104 0074-0074 590.992 µM 1.13233484047961 0.1562123044011 no 466 0.128746843890757 538 3943124
SGTC_1675 st018485 24.5 µM 1.13213393506179 0.156258952768692 no 467 0.128789064917122 685 3323024
SGTC_3285 9112818 20.8695 µM 1.12820352103364 0.157173404024893 no 468 0.129616988631984 717 17017947 YPR165W RHO1
SGTC_1408 3909-7976 48.8 µM 1.12725975532309 0.157393503719881 no 469 0.129816336245091 733 24152374
SGTC_400 oxethazaine 37.5 µM 1.12636273392036 0.157602889672191 no 470 0.130006006944493 649 4621 A local anesthetic.
SGTC_3201 9113999 49.47 µM 1.12616013607004 0.157650206113218 no 471 0.130048871790028 665 16649224
SGTC_3329 9141233 27.5565 µM 1.1236296191512 0.158241990954092 no 472 0.130585092673046 655 4909101 YNL103W MET4
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.12346640850878 0.158280209252797 no 473 0.130619729692921 797 688664
SGTC_2339 9000433 200 µM 1.12264265628759 0.158473196008658 no 474 0.130794645632814 601 2988954
SGTC_1914 st062367 72.6 µM 1.12106073371483 0.1588442377579 no 475 0.13113100565653 649 978205
SGTC_926 2268-1401 59.4 µM 1.12098317190297 0.158862444601181 no 476 0.131147512772326 690 2931578
SGTC_13 0199-0087 65 µM 1.11807913576992 0.159545121710036 no 477 0.1317665982617 704 4589825
SGTC_1451 4152-0210 104 µM 1.10637294676051 0.162316438748291 no 478 0.134282564988044 718 659563
SGTC_3268 9137683 49.47 µM 1.10600397072241 0.162404296351345 no 479 0.134362400364443 671 1953228
SGTC_174 3553-0389 74.3 µM 1.10359577018425 0.162978477742141 no 480 0.134884263429582 636 738071
SGTC_582 0987-0078 156 µM 1.10344189407956 0.163015210850145 no 481 0.134917655962985 829 1625765
SGTC_2195 6536160 144.242 µM 1.10289104320467 0.163146753385137 no 482 0.135037242165206 626 3834386
SGTC_765 1319-0117 244 µM 1.10274830287559 0.163180850856843 no 483 0.135068242033328 656 3487746 YGL099W LSG1
SGTC_951 1171-0579 82.7 µM 1.10233752780274 0.163279001670868 no 484 0.135157480021464 772 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1394 3474-0001 65.7 µM 1.10166107108108 0.163440718173721 no 485 0.135304523558697 617 5017666 YIL048W NEO1
SGTC_2243 6634756 200 µM 1.10060720858617 0.163692866049873 no 486 0.135533823409689 660 885676
SGTC_1439 4092-1168 46 µM 1.09888893346837 0.164104522991427 no 487 0.135908257132006 727 2886240
SGTC_1697 st025554 27.742 µM 1.09502821741347 0.165031903851464 no 488 0.136752137285812 666 1269519
SGTC_1438 4092-1045 4 µM 1.09287195740279 0.165551331984074 no 489 0.137225011126553 726 1351342
SGTC_3028 9087778 49.47 µM 1.08994821965596 0.166257327214183 no 490 0.137867977014353 705 17217395
SGTC_2100 5377183 190 µM 1.0888233882901 0.166529457545528 no 491 0.138115887855019 769 2844202
SGTC_1518 st038567 90.8 µM 1.08772441104455 0.166795610519797 no 492 0.138358393911496 698 77966
SGTC_1113 artemisinin 1.17947 µM 1.08514209339889 0.16742208187554 no 493 0.138929363243011 764 2240 An anti-malaria and mitochondrial poison.
SGTC_1227 3909-8010 46.6 µM 1.08492571479253 0.167474644172586 no 494 0.13897727887805 709 15982272
SGTC_2448 5185112 27.17 µM 1.08383691006365 0.167739295966107 no 495 0.139218558339952 663 5718189
SGTC_1326 1431-2094 10.8 µM 1.08265737885342 0.168026304044895 no 496 0.139480264316825 725 616278
SGTC_2440 5628896 157.78 µM 1.08241519966978 0.168085271100401 no 497 0.13953403868571 710 5522048
SGTC_2774 tamoxifen 10.92 µM 1.08194132665279 0.168200690698511 no 498 0.139639299999468 722 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2305 7443522 69.23 µM 1.08179400129393 0.168236584610145 no 499 0.139672036350485 768 5415886
SGTC_3312 9133330 71.43 µM 1.07849979423971 0.169040462092914 no 500 0.140405386769125 779 17617324
SGTC_1402 3909-7673 35.9 µM 1.07761119736151 0.169257726053757 no 501 0.140603651531952 709 5328014
SGTC_1384 3089-0840 101 µM 1.07724265266279 0.169347888642321 no 502 0.14068593737543 684 1069836
SGTC_2712 st079126 47.7 µM 1.0766138797883 0.169501785881405 no 503 0.140826400405896 674 3152970
SGTC_1030 k029-0042 36.7 µM 1.07491551133624 0.169917923673516 no 504 0.141206278342139 762 6080581
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.07429538876502 0.17007003050336 no 505 0.141345155555643 786 16486 A toxic proline analog.
SGTC_128 0906-2981 13.371 µM 1.07413200077477 0.170110121664883 no 506 0.141381761901762 659 6740226
SGTC_74 000s-0487 160.283 µM 1.07152619138421 0.170750337931509 no 507 0.141966450261732 713 677548
SGTC_3066 9117245 49.47 µM 1.0714197417175 0.170776524087902 no 508 0.141990370061742 757 17176980
SGTC_1482 3346-2049 8.48 µM 1.06950570584317 0.171247807137672 no 509 0.142420929586205 709 3826804
SGTC_3062 9077494 49.47 µM 1.0677529140252 0.171680116616053 no 510 0.142815991424083 712 16459633
SGTC_3304 9125678 46.087 µM 1.06727948861658 0.171797001982158 no 511 0.142922823734879 734 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1740 st038286 13.222 µM 1.0663610145613 0.17202391160416 no 512 0.143130238898173 718 716786
SGTC_3134 9127454 49.47 µM 1.06603527392183 0.172104431981636 no 513 0.143203848369671 756 24262820
SGTC_2302 7771753 200 µM 1.0659007656253 0.172137688330549 no 514 0.143234251435065 738 2203047
SGTC_3234 9132280 49.47 µM 1.06576877801282 0.172170325442336 no 515 0.143264088984838 742 17612295
SGTC_537 1334-0398 209 µM 1.0655776405176 0.172217595784987 no 516 0.143307305590506 779 5846986
SGTC_2635 hydroquinidine 100 µM 1.06502820893779 0.172353522192273 no 517 0.143431582294124 751 442912 An experimental heart treatment.
SGTC_3051 9093778 49.47 µM 1.06471537975923 0.172430945011197 no 518 0.143502374066479 676 17217378
SGTC_1197 1601-0112 267 µM 1.06461838942097 0.17245495387935 no 519 0.143524327313295 755 7350313
SGTC_1173 0443-0020 122 µM 1.06119275169301 0.173304299288972 no 520 0.14430115638062 727 5331295
SGTC_1266 0828-0227 32.9 µM 1.05993803826413 0.173616055563885 no 521 0.144586394540053 700 3913820
SGTC_3294 9122953 26.2835 µM 1.05797308565826 0.174105000135893 no 522 0.145033856464956 748 16459826
SGTC_1160 4092-0570 10.5 µM 1.05771256491975 0.174169891883523 no 523 0.145093252543953 748 4994975
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.05555288099022 0.174708428035611 no 524 0.145586268872792 969 16725076
SGTC_2912 7964298 10.93 µM 1.05416869908857 0.17505414123746 no 525 0.145902843939796 791 2975850
SGTC_594 1487-1584 10.8 µM 1.05400071217991 0.175096127150994 no 526 0.145941295537016 737 5013332
SGTC_273 hydroxyurea 18.1 mM 1.0539896011722 0.1750989044129 no 527 0.145943839046654 829 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3140 9094243 49.47 µM 1.05394524726521 0.175109991211948 no 528 0.145953992751013 780 19291112
SGTC_844 0330-0132 15.3 µM 1.053361351801 0.175255984506607 no 529 0.146087705093912 796 2828079
SGTC_2394 5221648 200 µM 1.05287437991684 0.175377802694783 no 530 0.146199284805416 842 788586
SGTC_714 4296-0578 26.1 µM 1.0515419118334 0.175711399848928 no 531 0.146504885303444 720 1589775
SGTC_1042 0350-0096 82 µM 1.0510814764432 0.175826768006835 no 532 0.146610585406819 718 3122515
SGTC_3046 9092212 49.47 µM 1.04970750564396 0.176171319628668 no 533 0.146926305929924 747 25236637
SGTC_2821 7996764 71.43 µM 1.04839074825722 0.176501924549391 no 534 0.147229307172633 776 2987135
SGTC_263 alizarin 107.927 µM 1.04829506190511 0.176525964289343 no 535 0.147251342032101 822 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2966 9084041 48.03 µM 1.04776222337933 0.1766598697327 no 536 0.147374085662541 689 17741380
SGTC_698 k064-0052 127 µM 1.04284170326549 0.177899458837116 no 537 0.148510806548922 754 5088751
SGTC_2475 5812728 15.03 µM 1.04258111995247 0.177965258193124 no 538 0.1485711685963 785 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_560 2332-1943 155 µM 1.04186933924974 0.178145066672126 no 539 0.148736130509176 761 21177716
SGTC_1527 coumarin 137 µM 1.04073960621153 0.178430692385562 no 540 0.148998208098726 698 323 A hepatotoxic, DNA x-linker.
SGTC_2317 5986382 200 µM 1.04061520512283 0.178462161820162 no 541 0.149027085740868 801 877883
SGTC_1668 st014914 51.6 µM 1.04054433723238 0.178480090657582 no 542 0.149043538213577 768 2839556
SGTC_3005 9076496 71.4286 µM 1.03992303938196 0.178637321108967 no 543 0.149187828767496 740 21368410
SGTC_2727 riluzole 51.77 µM 1.03931424171524 0.178791472746428 no 544 0.149329306732852 697 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2969 9091408 28.7 µM 1.03873157465477 0.178939086339146 no 545 0.149464796092339 723 4286311
SGTC_845 0330-0138 4.51 µM 1.03867863616865 0.178952501640228 no 546 0.149477110105794 760 9039800
SGTC_868 0527-0199 213 µM 1.03797071554001 0.179131958756087 no 547 0.149641844489842 781 2849450
SGTC_1038 k292-0204 154 µM 1.03599981379694 0.179632176287369 no 548 0.15010111469266 708 4454212
SGTC_1774 st048371 48.465 µM 1.03589773114778 0.179658108889189 no 549 0.150124928113159 776 4242727
SGTC_1947 st076332 61.6 µM 1.03565650689247 0.179719397724899 no 550 0.150181209921768 720 24208416
SGTC_1409 3909-8004 61.9 µM 1.03544900618895 0.17977212878819 no 551 0.150229634690876 789 2119279
SGTC_954 1189-0853 2.85 µM 1.03423289020774 0.18008136932911 no 552 0.150513650815783 794 2828194
SGTC_1724 st037281 8.293 µM 1.03402365885556 0.180134607459819 no 553 0.15056255150109 745 574124 YDL195W SEC31
SGTC_3148 9097893 49.47 µM 1.03375390126679 0.180203260842666 no 554 0.150625613742562 702 17174100
SGTC_1654 st012436 41.8 µM 1.03357711367955 0.180248262240628 no 555 0.150666951578957 721 4323132
SGTC_2956 9076196 2.52 µM 1.03293847521397 0.180410886838665 no 556 0.150816345882901 766 16423868
SGTC_1558 st069300 45.6 µM 1.03217767131144 0.180604740075675 no 557 0.150994446565289 708 24208000
SGTC_1832 st054113 55 µM 1.03205432319345 0.18063618154302 no 558 0.151023334971236 750 1251267
SGTC_2502 avocadyne acetate 18.59 µM 1.02914021590096 0.181379986454752 no 559 0.151706895308053 816 3952079
SGTC_1703 st026983 48.3 µM 1.02882498158329 0.181460562524953 no 560 0.151780962679258 820 1104023
SGTC_3189 9110682 49.47 µM 1.02848049326151 0.181548641739584 no 561 0.151861931036807 763 17122418
SGTC_2372 9071633 200 µM 1.02832557278012 0.181588260727374 no 562 0.151898352819806 852 21321366
SGTC_2947 9072639 7.68 µM 1.02583867034952 0.182224995546437 no 563 0.152483817495873 833 16488146
SGTC_71 0417-1750 47.813 µM 1.02551134135515 0.182308907121947 no 564 0.152560988409714 814 6811472
SGTC_711 k292-0785 179 µM 1.0214656872647 0.183348012873601 no 565 0.153516928887722 771 4146315
SGTC_597 k018-0003 82.8 µM 1.02024662833751 0.183661844572494 no 566 0.15380575426969 861 6786234
SGTC_2553 4-methylesculetin 85.09 µM 1.01984467886127 0.183765394843061 no 567 0.153901064895129 786 5319502
SGTC_715 0868-0130 184 µM 1.01880735396293 0.184032798604166 no 568 0.154147216880005 752 2876258
SGTC_2359 9039622 200 µM 1.01797222696392 0.184248255305664 no 569 0.154345577441662 826 6463596
SGTC_3147 9097027 49.47 µM 1.01752713049611 0.184363151062165 no 570 0.154451366310357 829 25236841
SGTC_2172 5754775 163.918 µM 1.01645266116714 0.18464069472182 no 571 0.154706939650888 702 2263357
SGTC_3241 9133421 49.47 µM 1.01611121920656 0.184728946164197 no 572 0.154788213530925 783 17018221
SGTC_2486 5283202 22.39 µM 1.01578388722781 0.184813575258745 no 573 0.15486615527158 735 1377751
SGTC_497 capsazepine 133 µM 1.01542927663581 0.184905284212833 no 574 0.154950621633033 760 2733484 A calcium channel blocker.
SGTC_2135 5326629 150.42 µM 1.01298337474784 0.185538610336886 no 575 0.155534051028491 715 5020077
SGTC_3169 9102970 49.47 µM 1.01018639147596 0.186264490987776 no 576 0.156202998941403 806 17027839
SGTC_860 0443-0016 25.1 µM 1.00684008473869 0.187135242043106 no 577 0.157005814140399 817 5337942
SGTC_2074 5212007 75.395 µM 1.00548653197858 0.187488167443326 no 578 0.157331315700637 739 758611
SGTC_1816 st051957 91.6 µM 1.00537496250177 0.187517276412183 no 579 0.15735816563779 796 674121
SGTC_2091 4-phenylthiadiazole 200 µM 0.999841454697533 0.188964495615132 no 580 0.158693620294326 816 270010
SGTC_1443 4112-3303 14 µM 0.999677517415115 0.189007476027695 no 581 0.158733297858041 810 704433
SGTC_1274 0865-0114 173 µM 0.997988657923132 0.189450604861469 no 582 0.159142429276637 793 870624
SGTC_3212 9128307 49.47 µM 0.99248978880773 0.190897841729523 no 583 0.160479329081011 687 27243542
SGTC_2798 7813637 45.45 µM 0.990250023318664 0.191489260043046 no 584 0.161025963786497 799 956368
SGTC_2777 climbazole 1.536 µM 0.990063384975962 0.191538593202478 no 585 0.161071569320342 840 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3037 9091026 49.47 µM 0.989987627202243 0.191558620089141 no 586 0.161090083321736 885 25236398 YIL048W NEO1
SGTC_1565 sinapyl alcohol 95.1 µM 0.988584401702373 0.191929800549898 no 587 0.161433260493636 771 5280507 A phenol propionate derived from cinnamic acid.
SGTC_336 4111-0029 111 µM 0.988510065841955 0.191949476102791 no 588 0.161451453588681 743 3131175
SGTC_1218 1348-1416 30.7 µM 0.98799684264619 0.192085352030147 no 589 0.161577097254529 800 6787668
SGTC_1859 st055998 20 µM 0.985449397649394 0.192760659179459 no 590 0.162201687842321 855 676301
SGTC_1707 st032323 6.317 µM 0.983883652703299 0.193176444410792 no 591 0.162586361131466 809 3132057 YMR211W DML1
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.981531477019695 0.193802095196281 no 592 0.163165359917848 816 97141
SGTC_2931 9014674 55.67 µM 0.981374264101772 0.193843955956611 no 593 0.163204106310162 789 2996810
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.980841829757671 0.193985767088573 no 594 0.163335373460083 896 368090
SGTC_17 0960-0276 49.807 µM 0.980763282591842 0.194006693069255 no 595 0.163354744398489 840 6821114
SGTC_3009 9080819 71.4286 µM 0.98031423934404 0.194126350403092 no 596 0.163465514017379 821 17027216
SGTC_1433 4060-0023 7.6 µM 0.978815989760489 0.194525916694265 no 597 0.163835453827689 840 3840627
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.978469549030282 0.194618379737069 no 598 0.163921072413432 742 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1539 benzyladenosine 56 µM 0.97726056984121 0.194941258792201 no 599 0.164220084221364 800 92208 A nucleotide analog.
SGTC_1190 1486-1332 13 µM 0.976878593595108 0.195043339908908 no 600 0.164314630308149 826 4150046
SGTC_611 3453-1652 23.7 µM 0.974857999797103 0.195583873251342 no 601 0.16481535112754 862 1560575
SGTC_442 cape 100 µM 0.972674399311214 0.196169034340941 no 602 0.165357576397995 805 5281787
SGTC_1428 4049-0204 61.7 µM 0.97242066867519 0.19623709783811 no 603 0.165420656812295 869 X1428
SGTC_1936 st074407 74.3 µM 0.972300163373071 0.196269428520474 no 604 0.165450621296796 860 809813
SGTC_40 0327-0103 19.753 µM 0.967934329887997 0.197442926184778 no 605 0.166538583928869 806 409036
SGTC_1281 0884-0031 11.8 µM 0.966076712484969 0.19794352139841 no 606 0.16700289818444 848 1548255
SGTC_2270 7924575 90.91 µM 0.964937191417115 0.198250981304551 no 607 0.167288135911665 860 1262135
SGTC_3029 9088683 49.47 µM 0.964218006256788 0.198445176558495 no 608 0.167468319333558 820 25236615
SGTC_2735 sertaconazole 140 nM 0.963742007827019 0.198573769330084 no 609 0.167587643907768 815 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1419 3993-2473 62.6 µM 0.96257162418391 0.198890166537261 no 610 0.167881271658377 855 704026
SGTC_3002 9075603 71.4286 µM 0.961503000659956 0.199179319502802 no 611 0.168149658731469 871 20105405
SGTC_2842 9000675 19.48 µM 0.959454918116716 0.199734206123995 no 612 0.168664810125885 778 2989072
SGTC_2529 gangaleoidin 93.61 µM 0.958888301284546 0.199887883593677 no 613 0.168807509433378 855 4565183
SGTC_421 streptovitacin 30 mM 0.958387977235754 0.200023640274031 no 614 0.1689335777444 873 91467 include heat shock
SGTC_256 clotrimazole 625 nM 0.95812197075812 0.200095840373378 no 615 0.169000628898992 831 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3000 9075062 71.4286 µM 0.957999378520176 0.200129119917699 no 616 0.169031535971704 802 17057871
SGTC_660 4031-1742 102 µM 0.954766190943539 0.201008018700549 no 617 0.169847974162681 858 6738706
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.954159466539196 0.201173206254733 no 618 0.170001464325419 903 676296 Flavone; oxidizing agent.
SGTC_987 1497-1013 404 µM 0.954065135586312 0.20119889622933 no 619 0.170025336312896 846 1676435
SGTC_3110 9122132 49.47 µM 0.952099705138446 0.201734606470643 no 620 0.170523209280722 877 918317
SGTC_3052 9092717 49.47 µM 0.951771951980792 0.20182402399005 no 621 0.170606324789509 819 25237534
SGTC_1673 st016611 27.3 µM 0.951227100793373 0.201972722635415 no 622 0.170744551960463 885 5226799
SGTC_2224 6650123 117.647 µM 0.950461973940438 0.202181648718899 no 623 0.170938783400567 825 2908370
SGTC_793 0488-0545 106 µM 0.94998509317521 0.202311931504271 no 624 0.171059913549139 851 292548
SGTC_3172 9105863 49.47 µM 0.949157525461553 0.202538140340353 no 625 0.171270250245198 806 2348785
SGTC_3041 9091929 49.47 µM 0.949100501473529 0.202553732945256 no 626 0.171284749692716 886 25236887
SGTC_1244 0416-0015 52.5 µM 0.948398224435453 0.202745821985385 no 627 0.171463381501843 841 96201
SGTC_1967 st070177 51.4 µM 0.947679071193929 0.202942639816486 no 628 0.171646429296589 836 5729214
SGTC_1337 1486-1011 40.3 µM 0.945403740854334 0.203566103368848 no 629 0.172226396556055 866 X1337
SGTC_1352 1496-0991 99 µM 0.9451973597901 0.203622710319903 no 630 0.172279063562074 851 3000039
SGTC_462 ag-879 158 µM 0.945075972882993 0.203656009147238 no 631 0.172310045451798 896 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1454 4239-0054 42.6 µM 0.944365966783579 0.203850842881069 no 632 0.172491333314546 919 1340767
SGTC_2134 5324836 1.464 µM 0.944028059710715 0.203943607421788 no 633 0.172577654788105 802 699272
SGTC_125 0133-0007 11.75 µM 0.942549568480213 0.204349788578784 no 634 0.172955672847738 976 26541
SGTC_502 l-744,832 89.3 µM 0.942227655596661 0.20443829047699 no 635 0.173038048859837 880 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_739 1486-1183 203 µM 0.941822675083839 0.204549662141125 no 636 0.173141716986753 895 4346692
SGTC_324 1315-0088 19.6 µM 0.940989765291301 0.204778829947124 no 637 0.173355052044712 788 6787421
SGTC_2228 7354201 200 µM 0.940773493173031 0.204838360282361 no 638 0.173410473664586 890 753451
SGTC_1357 1503-1303 39.5 µM 0.940675731567737 0.204865273189777 no 639 0.173435529631132 895 292895
SGTC_41 0478-0632 82.643 µM 0.938724530992443 0.205402861139627 no 640 0.173936097615092 944 3750424
SGTC_2391 6285546 200 µM 0.938520251943584 0.205459191795223 no 641 0.173988557166087 871 846083
SGTC_640 3381-0960 37.1 µM 0.937529530661191 0.205732516725699 no 642 0.17424312042317 917 1745025
SGTC_109 0132-0036 33.701 µM 0.937396709226817 0.205769176535527 no 643 0.17427726652884 745 67274 A color developer.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.937195086455689 0.205824833488712 no 644 0.174329108400108 885 23665772 A membrane-active detergent.
SGTC_1153 4055-0057 267 µM 0.937157817825846 0.205835122284791 no 645 0.174338692098447 880 882706
SGTC_1617 st002906 78 µM 0.935117403523736 0.206398887505751 no 646 0.174863899265031 887 5150859
SGTC_1983 st071813 46.9 µM 0.93213221415997 0.207225339953185 no 647 0.175634100819434 853 11838595
SGTC_2733 amorolfine 100 µM 0.93099951631297 0.207539439883723 no 648 0.175926907184519 831 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1778 st046819 58.9 µM 0.930262301688589 0.207744022402198 no 649 0.176117645723181 934 671715
SGTC_2998 9066762 71.4286 µM 0.927714088064144 0.208452087478386 no 650 0.176777949336782 885 4945196
SGTC_2900 5328528 85.29 µM 0.924237569281326 0.209420390011763 no 651 0.177681319594141 949 795359
SGTC_3151 9099821 49.47 µM 0.923904072716309 0.209513416550227 no 652 0.177768131223416 854 17174189
SGTC_1568 digitonin 820 nM 0.922762980080472 0.209831900207948 no 653 0.178065368459059 929 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1356 1502-0781 85.8 µM 0.920705792692899 0.210406788157809 no 654 0.178602025527234 859 567702
SGTC_2698 st077697 67.5 µM 0.920605938946017 0.210434716133331 no 655 0.178628100199694 829 3154499
SGTC_1545 lovastatin 49.4 µM 0.918161760997138 0.211119003604237 no 656 0.179267092384935 943 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1177 0983-0204 23.6 µM 0.917682678861804 0.211253283155265 no 657 0.179392509226207 937 766818
SGTC_470 aa-861 153 µM 0.916644329794361 0.211544488549372 no 658 0.179664523436458 894 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3286 9117135 37.221 µM 0.914191717886562 0.212233256952441 no 659 0.180308057633251 847 3438150
SGTC_3256 9138902 49.47 µM 0.913883802410135 0.212319821551857 no 660 0.180388952815534 933 17228773
SGTC_1865 st057639 52.2 µM 0.912231444944935 0.212784702864405 no 661 0.180823447038919 919 688818
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.910826634144475 0.213180405272681 no 662 0.181193363340842 932 23847180
SGTC_3264 9137442 49.47 µM 0.909718758711332 0.213492770386384 no 663 0.181485424346263 864 17015726
SGTC_891 0929-0073 133 µM 0.908367301000153 0.213874174368277 no 664 0.181842097887629 914 5603632
SGTC_1821 st053465 65.6 µM 0.907766348734853 0.214043900506805 no 665 0.182000840530228 854 675086
SGTC_1366 1683-0113 21.9 µM 0.90766682530002 0.214072016340911 no 666 0.18202713818881 897 708623
SGTC_2528 xanthyletin 44.79 µM 0.907503138214331 0.214118263379751 no 667 0.182070395350514 890 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1679 SEC14.276 6.7 µM 0.905615096440055 0.214652118036227 no 668 0.182569807745052 947 1005053 YMR079W SEC14
SGTC_665 3914-0008 307 µM 0.904108534334877 0.215078661499508 no 669 0.182968926729757 872 1069549
SGTC_982 1491-0518 27.5 µM 0.903579184672685 0.215228649696134 no 670 0.183109291397281 852 3091256
SGTC_1243 0416-0003 5.65 µM 0.901794186390009 0.215734866016427 no 671 0.183583104311586 880 2141977
SGTC_833 3852-0053 558 µM 0.901484529938185 0.215822753189166 no 672 0.183665377737528 960 3123681
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.900694218292146 0.216047154702043 no 673 0.183875461808415 895 279621
SGTC_2689 tacrolimus 100 µM 0.900359642214635 0.216142195117358 no 674 0.183964445345858 874 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1074 carmofur 3.8 µM 0.893239380459163 0.218170525570911 no 675 0.185864496596205 985 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_446 go6976 132 µM 0.892754243154888 0.218309123389219 no 676 0.185994397484809 897 3501 A protein kinase C inhibitor.
SGTC_2283 7944793 200 µM 0.892293030392676 0.21844093327891 no 677 0.18611794449138 929 2970533
SGTC_1547 harmine 94.2 µM 0.891886604648136 0.218557123580514 no 678 0.186226857620745 991 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_754 3474-0146 171 µM 0.891513286268002 0.218663880388717 no 679 0.186326933500005 848 24762078
SGTC_1180 1193-0155 285 µM 0.890599146490547 0.218925421074366 no 680 0.186572128633895 880 2921347
SGTC_760 0568-0725 82.9 µM 0.890211475309558 0.219036390361065 no 681 0.18667617203863 982 3916171
SGTC_1903 st060211 78.3 µM 0.890159807841549 0.219051182404538 no 682 0.186690041294277 979 688960
SGTC_836 0330-0104 1.35 µM 0.889924647794569 0.219118514378056 no 683 0.186753174079862 911 46494820
SGTC_1658 st012944 20 µM 0.888957779801736 0.219395476938224 no 684 0.187012885371255 872 24207260
SGTC_1921 5740136 50 µM 0.887627692192137 0.219776813464668 no 685 0.187370526321109 961 1774243
SGTC_606 k015-0008 38.6 µM 0.885707680661169 0.220327951847466 no 686 0.187887534198741 1004 1970475
SGTC_97 0535-0701 19.132 µM 0.882481709274376 0.221255747106737 no 687 0.18875818331697 858 2832013 YGL099W LSG1
SGTC_2291 7917025 104.35 µM 0.881900882595774 0.221423030999378 no 688 0.188915204876702 885 2964612
SGTC_3250 9135583 49.47 µM 0.880720786787318 0.221763133019085 no 689 0.189234481526578 909 7699353
SGTC_2417 cerulenin 830 nM 0.880501410840971 0.221826389749806 no 690 0.189293870609525 923 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3120 9124077 49.47 µM 0.878125285238067 0.222512202103984 no 691 0.189937866260978 973 18774327 YGL155W CDC43
SGTC_3337 9144342 33.5465 µM 0.877571992233056 0.222672070390727 no 692 0.190088017050873 945 17682949
SGTC_2920 7982904 15.77 µM 0.876810553344549 0.222892187287227 no 693 0.190294773001314 875 6456808
SGTC_2942 9052777 62.25 µM 0.876345397072003 0.223026715720188 no 694 0.190421146324731 1004 6469503
SGTC_1984 st072354 53.1 µM 0.875741757544873 0.223201363991052 no 695 0.190585219496719 935 5762938
SGTC_2534 helenine 20.12 µM 0.875195439012383 0.22335949493375 no 696 0.190733787238685 901 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2429 5902844 64.44 µM 0.8747835232861 0.223478765361311 no 697 0.190845852002177 981 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2786 7743617 45.45 µM 0.874738693366797 0.223491748075105 no 698 0.190858050755094 848 583674
SGTC_707 0865-0008 204 µM 0.874703252524343 0.223502012022354 no 699 0.190867694967389 996 723043
SGTC_3348 9149464 3.537 µM 0.873702573312843 0.223791927253855 no 700 0.191140124599618 950 1951442
SGTC_301 4119-0100 24.5 µM 0.871796576911771 0.224344720489354 no 701 0.191659681179239 935 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3181 9108277 49.47 µM 0.871358139834578 0.224471989295956 no 702 0.191779317230137 937 17097298
SGTC_1187 1391-0724 117 µM 0.868026529153822 0.22544042135746 no 703 0.192689904852278 959 6997986
SGTC_2775 cyproheptadine 69.59 µM 0.867281253142748 0.225657381347906 no 704 0.19289396289124 1005 2913 A selective serotonin reuptake inhibitor.
SGTC_1847 st056231 15 µM 0.867130622227506 0.225701246404762 no 705 0.192935221961437 1020 5393180
SGTC_1669 st015249 58.4 µM 0.86708479496822 0.225714592665615 no 706 0.192947775501124 1060 722793
SGTC_667 1498-1044 59 µM 0.866754654358663 0.225810752622213 no 707 0.193038226224962 983 6739982
SGTC_1682 st012968 530 nM 0.865795720930304 0.226090192225648 no 708 0.19330109810401 852 24207270
SGTC_1785 bathophenanthroline 24 µM 0.864555305897477 0.226451947196795 no 709 0.193641456246221 916 72812 An iron chelator.
SGTC_555 4296-0685 37 µM 0.863147698821382 0.226862857712491 no 710 0.194028132646897 982 2908540 YHR072W ERG7
SGTC_1996 st072960 66.8 µM 0.862403346666541 0.227080319879341 no 711 0.194232799778023 983 1719405
SGTC_2597 laccaic acid a 100 µM 0.862192527645369 0.227141931916524 no 712 0.194290790477623 929 5491415 A textile dye.
SGTC_431 k089-0097 107 µM 0.861664829645861 0.227296193409575 no 713 0.194435992363395 979 5499420
SGTC_2186 6124449 200 µM 0.859545213832983 0.227916413267034 no 714 0.195019893129552 949 3834182 YLR033W RSC58
SGTC_2762 leflunomide 42.06 µM 0.859334660000518 0.227978075277677 no 715 0.195077953556976 971 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_414 piperonyl butoxide 100 µM 0.858637878208639 0.228182199093991 no 716 0.195270166733476 936 5794 A potent inhibitor of cytochrome P450.
SGTC_1989 st071868 50.2 µM 0.857927251409716 0.228390484633457 no 717 0.195466317656175 999 16414057
SGTC_2836 9010338 19.48 µM 0.857652136955088 0.228471149677168 no 718 0.195542288307275 931 2994051
SGTC_2326 6164455 177.58 µM 0.856712132886462 0.228746884687277 no 719 0.19580199815937 906 2888790
SGTC_1819 st053448 58.6 µM 0.856193681323371 0.228899043981826 no 720 0.195945328534144 952 2857616
SGTC_1463 k081-0032 34.1 µM 0.854128115628473 0.229505826288275 no 721 0.196517003592422 838 977755
SGTC_757 1066-0008 322 µM 0.853948210766551 0.229558717927026 no 722 0.196566842653751 988 6842497
SGTC_1362 1611-0397 101 µM 0.85338613209805 0.229724011827443 no 723 0.196722604694533 971 27816
SGTC_3168 9103419 49.47 µM 0.852344007386846 0.230030652077692 no 724 0.197011593785671 920 16649256
SGTC_1940 st075990 51.1 µM 0.851578580829812 0.230256021031383 no 725 0.197224015964942 1020 1084979
SGTC_3332 9141069 11.198 µM 0.851309976768181 0.230335136935134 no 726 0.197298592147792 916 17332883
SGTC_3239 9133757 49.47 µM 0.850124211853226 0.230684579316871 no 727 0.19762801592763 983 17036923
SGTC_1472 k841-0093 193 µM 0.849899450068363 0.230750849508198 no 728 0.197690495678442 1023 X1472
SGTC_1221 2958-7315 257 µM 0.849868193774671 0.230760066154389 no 729 0.197699185313697 928 4562705
SGTC_2666 tannic acid 100 µM 0.849429394810357 0.230889477953161 no 730 0.197821201205371 1000 16134267 A thiamine antagonist.
SGTC_2600 tangeritin 87.95 µM 0.847613582941713 0.231425432783023 no 731 0.198326603647501 922 68077 A bioactive flavone.
SGTC_1147 3809-1045 12.3 µM 0.846368780302634 0.231793249022418 no 732 0.198673524509725 952 325925
SGTC_187 1488-2104 32.728 µM 0.84412492748536 0.232457088044895 no 733 0.19929979975282 1023 2852859
SGTC_2731 amoxapine 43.43 µM 0.844122981658557 0.232457664172036 no 734 0.199300343362288 956 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1223 0764-0573 147 µM 0.843776712349971 0.232560201432094 no 735 0.199397095518108 1028 1609797
SGTC_993 3909-8757 62.7 µM 0.843225788298305 0.232723392871018 no 736 0.199551089149334 901 4288324 YLR208W SEC13
SGTC_1278 0874-0585 172 µM 0.843050200126658 0.232775417923814 no 737 0.199600184382558 975 766306
SGTC_2508 celastrol 40.54 µM 0.842859438501831 0.232831946045715 no 738 0.199653530418051 924 122724 Celastrol is a natural product and antioxidant.
SGTC_755 1995-0008 37.3 µM 0.842515253673032 0.232933957140583 no 739 0.199749802588583 1004 689533
SGTC_1195 1502-0147 41.1 µM 0.840898341958288 0.233413517033995 no 740 0.200202443684267 1019 817940
SGTC_3266 9136860 49.47 µM 0.840852984909655 0.233426977375623 no 741 0.200215149897668 955 4871271 YPR165W RHO1
SGTC_433 pimozide 108 µM 0.840454488398038 0.233545255325038 no 742 0.2003268045735 897 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1351 1496-0003 46.5 µM 0.83978081061741 0.233745285532889 no 743 0.200515647304026 1006 3891978
SGTC_3249 9135183 49.47 µM 0.838502991994209 0.234124959616342 no 744 0.200874134012473 1020 4902779
SGTC_2883 9059145 45.46 µM 0.838344254991558 0.234172148459596 no 745 0.200918693858564 963 16476510
SGTC_2111 5486399 200 µM 0.838291241041066 0.234187909455169 no 746 0.200933576986814 1013 689674
SGTC_3326 9140064 16.379 µM 0.83785224782389 0.23431844427438 no 747 0.201056845289492 1012 1868434
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.836698093105136 0.234661824706699 no 748 0.20138114564335 910 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1090 efavirenz 20.7 µM 0.83626125657894 0.234791863471964 no 749 0.201503971970643 991 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3167 9103034 49.47 µM 0.835555652176854 0.235001993951444 no 750 0.201702463163756 959 5127859
SGTC_1699 st031318 29.054 µM 0.83507703782006 0.235144585436495 no 751 0.201837167185269 1027 5340658
SGTC_851 0394-0702 453 µM 0.833812517222035 0.235521548333208 no 752 0.202193320308081 1043 762646
SGTC_938 3126-1755 342 µM 0.832303517103498 0.235971828393272 no 753 0.202618822944951 1037 1777771
SGTC_614 0462-0418 107 µM 0.831516316954068 0.236206914177353 no 754 0.202841007183125 921 5188303
SGTC_3129 9127257 49.47 µM 0.830495086875419 0.236512081684814 no 755 0.203129462258013 879 837894
SGTC_2284 7945075 39.21 µM 0.830302516063394 0.236569650666017 no 756 0.203183882943109 1070 1245402
SGTC_153 4077-0274 519.67 µM 0.829998551996478 0.236660536312632 no 757 0.20326980117092 968 3121976
SGTC_2247 cerulenin 830 nM 0.829049877821962 0.236944314593756 no 758 0.203538092019407 1008 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2659 sanguinarine 24.21 µM 0.827057494352157 0.23754090761262 no 759 0.204102237343887 957 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_867 0518-0118 155 µM 0.826944079119939 0.237574893094835 no 760 0.204134378972168 1038 6848158
SGTC_1425 4048-4433 7.33 µM 0.826455940423407 0.237721196924825 no 761 0.204272750817147 1066 23734946
SGTC_2007 4011539 71.82 µM 0.826141688362145 0.237815409989573 no 762 0.204361860856827 978 45595301
SGTC_1963 st076565 50.3 µM 0.82595454620064 0.237871525113426 no 763 0.204414938312276 999 4914280
SGTC_2234 tolnaftate 200 µM 0.824372817343656 0.238346101039189 no 764 0.204863877582855 995 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1664 st014217 9.02 µM 0.824337194889016 0.238356795032723 no 765 0.204873994986418 1109 3982782
SGTC_693 4161-2696 114 µM 0.824124458546271 0.238420664745145 no 766 0.204934422033847 967 805759
SGTC_1279 0874-0590 65.2 µM 0.824121440277966 0.238421570985556 no 767 0.204935279439104 999 3523074
SGTC_1564 D-Arginine 115 µM 0.823955448014719 0.238471413361116 no 768 0.204982436463042 992 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1294 1000-1494 117 µM 0.823410348217875 0.238635130197524 no 769 0.20513734015721 984 712797 YDL207W GLE1
SGTC_1769 st044406 64.4 µM 0.822845988154229 0.238804696504978 no 770 0.205297790407969 997 670903
SGTC_2725 haloperidol 53.21 µM 0.821985367549337 0.239063403401263 no 771 0.205542612415296 1017 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_603 3794-0023 45.9 µM 0.821955897767846 0.239072264878325 no 772 0.205550998795524 1008 3802260
SGTC_3013 9080133 71.4286 µM 0.820283233901258 0.239575524204427 no 773 0.206027331001423 1053 17050193
SGTC_1349 flufenamic acid 69 µM 0.819953266675211 0.239674870670385 no 774 0.206121374537763 961 3371 A non-steroidal anti-inflammatory.
SGTC_720 r052-1644 49.9 µM 0.819418494506125 0.239835927502322 no 775 0.206273843308875 926 1422863 YOR257W CDC31
SGTC_1741 st038134 10.228 µM 0.819095492891209 0.239933234187195 no 776 0.206365966597848 1066 1272587
SGTC_1440 4100-1550 40 µM 0.818646816205468 0.240068437159234 no 777 0.206493974120412 1046 742806
SGTC_1929 genistein trimethyl ether 50.5 µM 0.818587327564168 0.240086366417395 no 778 0.206510949769377 1049 136420
SGTC_856 0433-0016 11.3 µM 0.818350916780221 0.240157625384634 no 779 0.20657842000291 1009 3911780
SGTC_358 0075-0058 9.45 µM 0.816594639470853 0.240687363454032 no 780 0.207080059754344 1050 1069125
SGTC_562 3772-2733 112 µM 0.816368561198035 0.240755600605604 no 781 0.207144686066932 1073 2876874 YIL048W NEO1
SGTC_815 1582-0027 36.9 µM 0.816326069122765 0.24076842715383 no 782 0.207156834103916 1021 3128206
SGTC_783 0848-0141 92.7 µM 0.813747488376678 0.241547486423227 no 783 0.207894811596713 956 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2099 5377090 177.372 µM 0.813192277456858 0.241715409643321 no 784 0.208053913184405 981 2243829
SGTC_2841 9004761 38.96 µM 0.812585863408136 0.241898891595968 no 785 0.208227769666385 991 2991039
SGTC_1734 st037168 69.4 µM 0.812558429317425 0.241907194081175 no 786 0.208235636936633 962 708907
SGTC_1265 0819-1001 68.8 µM 0.812163836926443 0.242026628206899 no 787 0.20834881354107 1008 3106768
SGTC_1820 st053765 18.6 µM 0.811100437116537 0.24234865425869 no 788 0.208653997430199 1031 3690829
SGTC_130 0136-0219 337.655 µM 0.810597535054999 0.242501027347065 no 789 0.208798416440277 1009 234244
SGTC_2266 7929956 200 µM 0.810180604071788 0.242627391597075 no 790 0.208918191675003 1058 2967153
SGTC_91 0417-1751 58.384 µM 0.809662290842932 0.242784532673178 no 791 0.209067148252286 1182 6795624
SGTC_2730 imipramine 71.33 µM 0.808201431824421 0.243227728988681 no 792 0.209487316814112 1097 3696 A tricyclic antidepressant.
SGTC_465 cgp-37157 41 µM 0.807580275925555 0.243416308083314 no 793 0.209666122513969 936 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_167 3672-0051 66.205 µM 0.806690837537103 0.243686473572943 no 794 0.209922312112898 1004 3237971
SGTC_124 0136-0217 7.121 µM 0.806245832136396 0.243821703990833 no 795 0.210050558369441 1178 3976905
SGTC_1629 st005085 44.9 µM 0.805057697830741 0.24418295840062 no 796 0.210393192638858 1022 24207091
SGTC_939 1165-0479 45.3 µM 0.80233360364108 0.245012312453786 no 797 0.211180004571298 1024 1377347
SGTC_96 0929-0093 37.281 µM 0.801953328640013 0.245128208095234 no 798 0.211289978032239 983 6991579
SGTC_2197 6588183 93.1375 µM 0.799558886783396 0.245858634083582 no 799 0.211983207901939 1019 884136
SGTC_2470 5664817 21.68 µM 0.799446320410065 0.245893001253274 no 800 0.212015830403848 1048 2859561
SGTC_3275 9138069 49.47 µM 0.798247079851844 0.246259296377503 no 801 0.212363560706606 1034 17617007
SGTC_1783 st039459 87.517 µM 0.798242257078358 0.24626077003215 no 802 0.212364959784491 1099 729761
SGTC_384 k007-0144 5.16 µM 0.797088066893238 0.24661358221874 no 803 0.212699943134761 1046 6824886
SGTC_1479 0549-0158 134 µM 0.797055154975006 0.246623646683468 no 804 0.212709499760788 1111 5440202
SGTC_2704 st078022 71.1 µM 0.796629615377274 0.246753796503014 no 805 0.21283308616936 1051 54697681
SGTC_2623 humulene 100 µM 0.794371337579583 0.247445097964121 no 806 0.213489642602123 940 6187145 An anti-inflammatory.
SGTC_1900 st060200 72.8 µM 0.793183018064713 0.247809280172137 no 807 0.213835600040384 1044 688945
SGTC_2338 7999974 200 µM 0.792969510552518 0.247874743758608 no 808 0.213897793416674 1118 315925
SGTC_2939 9044578 71.43 µM 0.792445301746987 0.248035510684525 no 809 0.214050536762631 1043 2653634
SGTC_2734 clemastine 41.6 µM 0.792425032320466 0.248041728128542 no 810 0.214056444118831 986 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3309 9129340 25.759 µM 0.791099952513847 0.248448363450807 no 811 0.214442833447761 1082 17158987
SGTC_2351 9026858 72.31 µM 0.790584745320687 0.248606564089952 no 812 0.214593175761971 1014 1409300
SGTC_2782 7736369 71.43 µM 0.788910218653423 0.249121118296621 no 813 0.215082241394243 1088 2950836 YOL077C BRX1
SGTC_2695 st077686 51.995 µM 0.788423173305833 0.24927088551292 no 814 0.215224610229192 1055 2876092
SGTC_2537 larixol 68.93 µM 0.786989689732981 0.249711961643802 no 815 0.215643950859144 1075 6708759
SGTC_708 3448-5400 146 µM 0.783904055243406 0.250662801351787 no 816 0.216548205049145 1077 3462195
SGTC_3245 9134821 49.47 µM 0.783822574202787 0.250687935734173 no 817 0.216572112997752 1062 17014901
SGTC_1161 k007-0610 110 µM 0.783204449743097 0.25087865148527 no 818 0.216753531145827 1123 5843850
SGTC_1011 4112-3381 17.4 µM 0.782975549948288 0.25094929557225 no 819 0.21682073501498 1056 2877139
SGTC_2409 alverine citrate 63.97 µM 0.781959885675788 0.251262881409167 no 820 0.217119074401228 1055 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_641 4092-0595 30 µM 0.781116524962182 0.251523425977266 no 821 0.217366981786845 1073 786260
SGTC_3135 9127742 49.47 µM 0.780802701307976 0.251620413862382 no 822 0.217459272518762 989 3643468
SGTC_3208 9114115 49.47 µM 0.778769406345735 0.252249286446517 no 823 0.218057781268714 993 650895
SGTC_2156 5649887 115 µM 0.776822975807129 0.252852068476323 no 824 0.218631609686632 1129 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_601 0986-0029 62.9 µM 0.776603384942238 0.252920120228818 no 825 0.218696401929906 1058 24747981
SGTC_2301 7769476 200 µM 0.775769260015295 0.25317870543202 no 826 0.21894261862814 1049 977820
SGTC_2852 9023854 51.95 µM 0.775035586246408 0.253406264875507 no 827 0.219159315933203 1081 19798528
SGTC_1378 2093-0007 380 nM 0.773709122193511 0.253817959436704 no 828 0.219551412141872 1051 3618014
SGTC_2355 9061122 103.12 µM 0.773667198030334 0.253830977158257 no 829 0.21956381128205 1074 5302957
SGTC_2480 5767542 37.17 µM 0.772221388658518 0.254280124608485 no 830 0.219991657811005 1091 2867358
SGTC_1055 3448-0672 86 µM 0.772180452652558 0.254292847633315 no 831 0.220003778627584 1035 748378
SGTC_517 1365-0151 113 µM 0.772034188212307 0.254338309755712 no 832 0.220047089462265 1053 768657
SGTC_1622 st003707 19.4 µM 0.771543870821723 0.254490741981847 no 833 0.220192314602136 1091 10140899
SGTC_3307 9126885 69.2785 µM 0.771262536108226 0.254578226276505 no 834 0.220275666812341 1068 24824909
SGTC_1632 st005650 90 µM 0.770589822169704 0.254787478337129 no 835 0.220475047910089 1053 2759605
SGTC_2393 9031399 185.94 µM 0.769134432991677 0.255240494576806 no 836 0.220906754515449 1098 1526623 YDL150W RPC53
SGTC_3178 9107506 49.47 µM 0.768014068355393 0.255589515018102 no 837 0.22123941344696 1060 8897194
SGTC_447 ml7 120 µM 0.767275636505277 0.255819690460944 no 838 0.221458825386179 1121 4216 Selective myosin light chain kinase inhibitor.
SGTC_514 4466-0038 2.65 nM 0.766929129997953 0.255927736751232 no 839 0.221561826523503 1075 5722064
SGTC_248 streptozotocin 5.23457 mM 0.766669909408811 0.256008581458636 no 840 0.221638899298758 1132 5300 DNA alkylating agent.
SGTC_2732 terfenadine 20 µM 0.76600806154028 0.256215056410766 no 841 0.221835752732881 1089 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.765568513318607 0.256352229084168 no 842 0.221966542740713 1086 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_424 splitomicin 100 mM 0.764598621018549 0.256655045036214 no 843 0.222255295279067 1005 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1612 st002233 45.4 µM 0.764364466494376 0.256728179741171 no 844 0.222325038952115 1131 1035021
SGTC_962 1254-0300 21.5 µM 0.76288163713465 0.257191571354392 no 845 0.222766994195325 1065 7340576
SGTC_313 3474-0040 5.03 µM 0.762475418910874 0.257318592427466 no 846 0.222888154282729 1095 1043375 YIL048W NEO1
SGTC_105 0111-0055 734.78 µM 0.76212058872927 0.257429571557392 no 847 0.222994017901954 993 5179370
SGTC_344 k064-0035 6.43 µM 0.760342550843865 0.25798605721704 no 848 0.223524926770242 1061 5088750
SGTC_1563 conessine 56.1 µM 0.758752405837728 0.258484264702519 no 849 0.224000340638458 1198 441082 An anti-amoebic, histamine inhibitor.
SGTC_1194 1488-0194 225 µM 0.758747688443185 0.258485743447939 no 850 0.224001751876401 1086 1391452
SGTC_2071 5230951 39.92 µM 0.757141766289388 0.258989400865572 no 851 0.224482466952603 1170 1799272
SGTC_223 busulfan 5 mM 0.75636194729713 0.259234154587513 no 852 0.224716108151638 1045 2478 A DNA alkylator.
SGTC_2231 micatex 6.853 µM 0.756187240806651 0.259289004293436 no 853 0.224768470783474 1103 20737 An antifungal of unknown mechanism.
SGTC_2244 6635614 200 µM 0.755550736368297 0.259488887773486 no 854 0.224959300956611 952 836499
SGTC_2446 5162541 200 µM 0.754540922306263 0.259806166040773 no 855 0.225262241282611 1039 1549321
SGTC_927 2425-1185 123 µM 0.75394474792963 0.259993574821387 no 856 0.225441199711096 1120 730375
SGTC_804 1595-0054 20.9 µM 0.751400942312771 0.260794008569846 no 857 0.226205697900556 1059 761523 Stimulates phospholipase C.
SGTC_151 3013-0144 2.285 µM 0.747340562992801 0.262074269142301 no 858 0.227429006678849 1090 906558 YHR107C CDC12
SGTC_1829 berberine 14.4 µM 0.746837241298758 0.262233193428159 no 859 0.227580906322664 1109 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1916 st067606 49.2 µM 0.746162462760942 0.262446332807363 no 860 0.227784640275262 1146 19590279
SGTC_1708 st033234 31.827 µM 0.745912326642805 0.262525364748344 no 861 0.227860189226788 1165 674664
SGTC_1920 st075728 45.7 µM 0.745618316660721 0.262618274460079 no 862 0.227949007483914 1097 3400306
SGTC_1178 0988-0033 191 µM 0.745077706023316 0.262789156026799 no 863 0.228112372807682 1126 5392207
SGTC_171 k064-0041 9.68 µM 0.744846039831572 0.262862400774681 no 864 0.228182399387146 1048 53325
SGTC_119 0121-0043 24.815 µM 0.744137097496402 0.2630866083816 no 865 0.22839676902403 1217 1092378
SGTC_1519 esterone 74 µM 0.743384891566301 0.263324605185399 no 866 0.22862434437064 1116 698 A steroid.
SGTC_2061 5245884 80.95 µM 0.742794076990973 0.263511615070391 no 867 0.22880318099756 1140 573863
SGTC_315 k915-0449 187 µM 0.74148574026288 0.263925982559007 no 868 0.229199487357765 1154 20970215 YNL149C PGA2
SGTC_62 0180-0423 3.232 µM 0.740056758899857 0.264378938970965 no 869 0.229632777484455 1124 30102 YGL099W LSG1
SGTC_2163 5671233 125 µM 0.7396403862922 0.264510994557827 no 870 0.229759114625883 1168 701023
SGTC_2664 lyso-paf C-16 73.48 µM 0.739294245060637 0.264620801298468 no 871 0.22986417155492 1144 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_69 0096-0274 206.684 µM 0.738104442423594 0.264998420369213 no 872 0.230225492208411 1281 6741392
SGTC_2009 4012297 12.05 µM 0.737578228438189 0.265165517227294 no 873 0.230385394746034 1095 45595307
SGTC_1548 st061468 90.8 µM 0.73675973266556 0.265425533137838 no 874 0.230634237362222 1155 390799
SGTC_1970 st070122 35.8 µM 0.735981924645543 0.265672743389648 no 875 0.230870849012193 1161 102928
SGTC_1887 st057648 70.8 µM 0.735969320012372 0.265676750473666 no 876 0.23087468449709 1124 688672
SGTC_1193 1488-0126 41.5 µM 0.735149447848636 0.265937458269637 no 877 0.231124241181278 1187 1384710
SGTC_1305 1181-0477 144 µM 0.733959112286317 0.266316198772785 no 878 0.231486829098779 1125 6252086
SGTC_768 0384-0033 77.3 µM 0.732766902352699 0.26669580908907 no 879 0.231850305633112 1102 3965305 YMR134W ERG29
SGTC_2323 6148992 148.28 µM 0.732699511032239 0.266717275253657 no 880 0.231870861136784 1083 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_506 n9-isopropylolomoucine 153 µM 0.732184906805882 0.266881220984567 no 881 0.232027857678793 1142 6610355
SGTC_2830 7992007 71.43 µM 0.73215479129897 0.266890816941822 no 882 0.232037047213841 1064 1952075
SGTC_1942 st076330 65.2 µM 0.73080734620893 0.267320342999253 no 883 0.232448417894357 1183 24208414
SGTC_2360 9040895 200 µM 0.729183111461283 0.267838564682279 no 884 0.232944830257044 1095 4914414
SGTC_984 1492-0255 2.91 µM 0.728728717072834 0.267983632432937 no 885 0.233083811449549 1080 1585198
SGTC_1331 1472-0049 76.2 µM 0.724940004858105 0.269194736419929 no 886 0.234244418591989 1135 24051409
SGTC_2495 cafestol 54.53 µM 0.724285382531578 0.269404271578131 no 887 0.234445274575037 1180 16667697 An anti-infammatory.
SGTC_2838 9002687 71.43 µM 0.721687857720242 0.270236506872397 no 888 0.235243204500673 1131 6457060
SGTC_3171 9103192 49.47 µM 0.720419660011333 0.270643298267665 no 889 0.235633324435767 1207 13018434
SGTC_103 0844-0104 51.839 µM 0.720048882284412 0.270762287937664 no 890 0.2357474495712 1219 5375804
SGTC_2812 7970281 58.44 µM 0.719614469479462 0.270901732539748 no 891 0.235881200307087 1169 2233435
SGTC_2390 9097792 176.6 µM 0.718351903819721 0.271307213898032 no 892 0.236270167184082 1128 4497149
SGTC_202 3594-0513 34.79 µM 0.71727425458668 0.271653547226133 no 893 0.23660244484476 1145 708429
SGTC_409 arachidonic acid 100 µM 0.716974997435096 0.271749761082939 no 894 0.236694762078905 1196 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_272 doxorubicin 8.13 µM 0.716844537879141 0.271791710307501 no 895 0.23673501348437 1181 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1412 3909-8563 178 µM 0.715472093780332 0.272233214402501 no 896 0.237158689269486 1222 23767530
SGTC_352 k048-0007 5.11 µM 0.71473872785206 0.272469278272 no 897 0.237385251210748 1157 6811911
SGTC_257 daunorubicin 18.5 µM 0.714636268303924 0.272502267166531 no 898 0.237416913945357 1197 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_213 1246-0773 967 nM 0.712663446925318 0.27313784280303 no 899 0.238027020301691 1140 6251622
SGTC_1826 st055655 41.6 µM 0.712592560146267 0.27316069376583 no 900 0.238048958428514 1160 676168
SGTC_3185 9108267 49.47 µM 0.712167350311262 0.273297783692983 no 901 0.23818057614575 1163 4910486
SGTC_3104 9120930 49.47 µM 0.710853525027775 0.27372158319295 no 902 0.238587504080248 1165 17014836
SGTC_134 0269-0018 6.916 µM 0.710444487178613 0.273853592508386 no 903 0.238714272017711 1088 4378915
SGTC_942 3253-1115 227 µM 0.708880898320324 0.274358501532801 no 904 0.239199194891757 1203 46497897
SGTC_2206 7254556 146.969 µM 0.708815400637591 0.274379661855358 no 905 0.239219519723581 1174 4398905
SGTC_2719 novobiocin 32.65 µM 0.705068985822937 0.275591354437154 no 906 0.24038365303937 1173 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_268 camptothecin 39.6153 µM 0.704942407649277 0.275632339172646 no 907 0.240423038827393 1182 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2213 7173844 200 µM 0.704458569932389 0.275789028558125 no 908 0.240573621104604 1173 892728
SGTC_2069 5228469 200 µM 0.70432883709206 0.27583104958793 no 909 0.240614005904871 1144 2835210
SGTC_3143 9086658 49.47 µM 0.704039785617099 0.275924685926369 no 910 0.240703998597963 1229 25236626
SGTC_2950 9072895 21.46 µM 0.702961563607454 0.276274106596523 no 911 0.241039851582728 1152 17332245
SGTC_3356 9151811 4.48 µM 0.702140578058014 0.27654030986069 no 912 0.241295749334394 1173 1859254 YPR165W RHO1
SGTC_232 clozapine 119 µM 0.700332628911284 0.277126977502506 no 913 0.241859799630089 1145 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1032 k061-1018 98.7 µM 0.699877348768093 0.277274808855671 no 914 0.242001952196687 1258 4005393
SGTC_577 r071-0003 38.6 µM 0.699747663160674 0.277316925367807 no 915 0.242042452352106 1233 4568517 YMR134W ERG29
SGTC_2963 9082507 9 µM 0.698613348603997 0.277685437030593 no 916 0.242396849645713 1179 16459611
SGTC_408 cantharidin 100 µM 0.696652421034427 0.278323059096241 no 917 0.243010170646072 1152 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2961 9083290 32.55 µM 0.695958875855388 0.278548745392559 no 918 0.24322729213691 1152 17741490
SGTC_507 nimesulide 162 µM 0.695760604919454 0.278613281049396 no 919 0.243289382173548 1208 4495 A COX2 inhibitor.
SGTC_2210 7115885 190.385 µM 0.69349117506796 0.279352481125535 no 920 0.244000681051589 1216 2927039
SGTC_1375 2910-0797 186 µM 0.693237578726392 0.279435141827064 no 921 0.244080234426769 1187 742508
SGTC_2893 9048488 25.97 µM 0.692288729197433 0.279744528311711 no 922 0.244378013331918 1169 6467338
SGTC_2642 cholecalciferol 100 µM 0.691491107227986 0.280004733320091 no 923 0.244628483640835 1179 9821465 A vitamin D precursor, similar to steriods.
SGTC_3146 9095609 49.47 µM 0.690717047391413 0.280257363882749 no 924 0.244871687060169 1221 17173999
SGTC_1250 0485-0349 40.2 µM 0.690637383134679 0.280283370238449 no 925 0.244896724316566 1196 6842794 YDL195W SEC31
SGTC_2723 salbutamol 83.58 µM 0.690283115620193 0.280399034841179 no 926 0.245008081856414 1176 9884233 β2-adrenoceptor agonist
SGTC_2934 9036370 36.88 µM 0.689665313109054 0.280600796111873 no 927 0.245202341978286 1207 6462800
SGTC_2699 st077704 54.6 µM 0.688815919463219 0.280878304788525 no 928 0.245469558126436 1201 645852
SGTC_2824 7998404 51.95 µM 0.687476978763885 0.281316024494166 no 929 0.245891101517772 1174 837851
SGTC_2416 tofa 880 nM 0.687254416148108 0.281388815440031 no 930 0.245961209323974 1141 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2552 juarezic acid 87.02 µM 0.685663098874669 0.281909533596965 no 931 0.246462790782613 1282 1549512
SGTC_829 1635-0120 117 µM 0.685479768760538 0.28196955353007 no 932 0.246520611422346 1227 285054
SGTC_200 k038-0079 37.545 µM 0.68471461056015 0.282220122965942 no 933 0.246762013758116 1175 3436683
SGTC_876 0720-0963 56.8 µM 0.684407259709286 0.282320802546559 no 934 0.246859016530511 1232 765861
SGTC_3057 9095946 49.47 µM 0.68360923390227 0.282582294233556 no 935 0.247110976128287 1243 24540043
SGTC_1304 1165-0502 251 µM 0.683608580791778 0.282582508288049 no 936 0.24711118239029 1223 767425
SGTC_1932 st074806 40.9 µM 0.682264433763868 0.283023212460438 no 937 0.247535879062221 1318 17251235
SGTC_3117 9124945 49.47 µM 0.68195440964055 0.283124906569452 no 938 0.247633889594455 1143 17592065
SGTC_3263 9137018 49.47 µM 0.6819472446707 0.283127257030051 no 939 0.247636154961632 1175 43844957
SGTC_2818 7996756 12.99 µM 0.681904254457877 0.283141360119433 no 940 0.247649747521626 1213 2241621
SGTC_2750 bromebric acid 70.15 µM 0.681470524497677 0.283283665599304 no 941 0.247786905685813 1235 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2773 thioridazine 9.09 µM 0.680289943840478 0.28367118417758 no 942 0.248160445339884 1232 5452 An antipsychotic.
SGTC_2333 9017922 200 µM 0.67981205749244 0.283828119688999 no 943 0.248311735520491 1242 3163164
SGTC_857 0438-0306 1.35 µM 0.678791658076397 0.284163352862613 no 944 0.248634940053006 1241 4686136
SGTC_2913 7966556 36.57 µM 0.678363473850579 0.284304081168347 no 945 0.24877063118889 1162 2976516
SGTC_579 4491-1009 110 µM 0.677160982374674 0.284699473644897 no 946 0.249151910241507 1356 1271041
SGTC_328 k915-0120 63.5 µM 0.675443518961934 0.285264649329153 no 947 0.249697012143991 1199 6624543
SGTC_990 3985-0011 41.3 µM 0.674973205963927 0.285419511147167 no 948 0.249846394134753 1203 5399565 YGL099W LSG1
SGTC_1659 st012954 42.1 µM 0.674621469820131 0.285535354855644 no 949 0.249958144448761 1215 24207262
SGTC_2630 antimycin a 100 µM 0.674490759476595 0.285578409790986 no 950 0.249999679274407 1237 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2245 6637752 200 µM 0.673945328119477 0.285758103830463 no 951 0.250173036341193 1200 681890
SGTC_2722 naftopidil 47.16 µM 0.672631668160696 0.286191113759577 no 952 0.250590824751491 1206 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.67174679671486 0.286482961531368 no 953 0.250872452073096 1287 5393153
SGTC_1455 4262-0120 131 µM 0.670027319264382 0.287050482028773 no 954 0.251420187510848 1309 1529587
SGTC_553 k007-0256 45.7 µM 0.669465877959827 0.287235903242631 no 955 0.251599170083533 1274 6287000
SGTC_1818 st052136 56.3 µM 0.668815762862842 0.2874506805978 no 956 0.25180650514888 1149 674169
SGTC_2804 7954240 19.48 µM 0.668610799964795 0.287518409565771 no 957 0.251871890727064 1235 828705
SGTC_985 1493-0307 8.71 µM 0.668077749830735 0.287694588646117 no 958 0.252041981951123 1226 3278274
SGTC_2799 7812892 81.82 µM 0.667958404006945 0.287734040774948 no 959 0.252080072369023 1231 20205235
SGTC_2240 6690706 185.951 µM 0.667680736983928 0.287825839006399 no 960 0.252168704337674 1185 805876
SGTC_2792 7535235 81.82 µM 0.667359433874776 0.287932080827599 no 961 0.252271285557674 1202 1281891
SGTC_220 paclitaxel 373.376 µM 0.666755863838929 0.288131706844009 no 962 0.252464044535357 1222 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2011 4012611 177 µM 0.665866583381766 0.288425948255492 no 963 0.252748190704476 1245 2049887
SGTC_2849 9019321 12.99 µM 0.659663442364663 0.290482347007371 no 964 0.254734915826958 1231 16489627
SGTC_1431 4049-0260 9.09 µM 0.659456766139396 0.29055098006134 no 965 0.254801249996347 1244 3854841
SGTC_1049 3226-0134 66 µM 0.658951451242322 0.290718817012954 no 966 0.254963472395142 1287 5702385
SGTC_2990 9074105 71.4286 µM 0.656809573606019 0.291430730203651 no 967 0.255651683822223 1226 6502001
SGTC_2185 6113692 200 µM 0.654680644920305 0.292139144325018 no 968 0.256336694689457 1260 874150
SGTC_2679 rapamycin 1 nM 0.652657855475804 0.292812981460125 no 969 0.256988439034211 1248 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3053 9095903 49.47 µM 0.651805513870616 0.293097131744324 no 970 0.257263322090039 1318 17174018
SGTC_3229 9132204 49.47 µM 0.650640787616681 0.29348563024531 no 971 0.257639197225402 1261 17682924
SGTC_215 1287-0124 461.5 µM 0.65042477754577 0.293557707367948 no 972 0.2577089383416 1280 5560863
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.649017753457621 0.294027396338774 no 973 0.258163450532033 1285 6708561
SGTC_1575 cyproterone acetate 48 µM 0.646081611600487 0.295008648473484 no 974 0.25911325170167 1227 9880 An androgen receptor antagonist and liver toxin.
SGTC_1391 3442-0225 151 µM 0.645659595155924 0.295149809348775 no 975 0.259249916517161 1254 5227075
SGTC_2292 7671323 168.05 µM 0.645599633720087 0.295169868457108 no 976 0.259269337309977 1260 937504
SGTC_2006 4011487 200 µM 0.64548233682343 0.295209110011984 no 977 0.259307330547481 1313 45595294
SGTC_2800 7887935 81.82 µM 0.644712822785915 0.295466609673175 no 978 0.259556652540107 1270 2961002
SGTC_2607 solasodine 47.35 µM 0.643076220478258 0.29601460310554 no 979 0.260087321782825 1283 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_380 3970-0968 6 µM 0.642562565645524 0.296186689395611 no 980 0.260253989911627 1253 2891601
SGTC_2817 7995342 71.43 µM 0.641779046530723 0.296449274841523 no 981 0.260508328203296 1239 18879975
SGTC_919 tnp00227 403.569 nM 0.641492237119318 0.296545421663913 no 982 0.260601461451096 1298 1269246 A methoxyflavone. YNL221C POP1
SGTC_538 2922-0838 53.3 µM 0.640056575138982 0.297026911748422 no 983 0.26106790958304 1320 777039
SGTC_1473 k844-0725 134 µM 0.640046728502294 0.297030215332422 no 984 0.261071110247245 1329 54682906
SGTC_983 1491-0821 12.2 µM 0.639694001103517 0.297148567795769 no 985 0.261185778125982 1251 46495113
SGTC_1590 st077108 57.8 µM 0.63936540865203 0.297258841527466 no 986 0.261292623274489 1264 5489485
SGTC_1775 st081588 35.1725 µM 0.63841423478381 0.297578155362859 no 987 0.261602033570491 1302 1426443 YGL099W LSG1
SGTC_2021 4019055 173 µM 0.637767456714447 0.297795371391702 no 988 0.261812533372703 1284 44827708 YER133W GLC7
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.637707633701407 0.297815466198341 no 989 0.261832007704859 1269 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2975 9084847 53.72 µM 0.634610511878182 0.298856646331252 no 990 0.26284123530104 1328 27211724
SGTC_49 0717-0965 32.132 µM 0.63431351856933 0.298956575400022 no 991 0.262938117912031 1357 5889349 YGL099W LSG1
SGTC_2497 7-hydroxyflavone 100 µM 0.632814067112918 0.29946132603533 no 992 0.263427534720465 1306 5281894
SGTC_719 2810-4230 27.3 µM 0.632535777021009 0.299555047518024 no 993 0.263518418973483 1272 721079
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.632098942686073 0.299702189734213 no 994 0.263661113029113 1319 5377381
SGTC_2423 st077119 87.2 µM 0.631576648840513 0.299878160883392 no 995 0.263831774571683 1255 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_619 1652-1634 108 µM 0.631464169698534 0.299916063455745 no 996 0.263868534937637 1259 5400454
SGTC_140 0062-0056 502.533 µM 0.629143399819615 0.300698586493955 no 997 0.264627589874203 1254 3758964
SGTC_1546 5-methoxyflavanone 78.7 µM 0.628407535034218 0.30094689950518 no 998 0.264868501108998 1343 147795
SGTC_647 0140-0236 81 µM 0.627054577066892 0.301403687881742 no 999 0.265311730231382 1304 990837
SGTC_76 0433-0009 400.328 µM 0.626360473353322 0.301638153629951 no 1000 0.265539264688334 1307 2841569
SGTC_1872 amphotericin b 148 nM 0.62576399593561 0.301839707076458 no 1001 0.265734875274922 1294 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_46 0329-0187a 2.197 µM 0.624833143448567 0.30215436881658 no 1002 0.266040287711187 1337 46494817
SGTC_23 0213-0011 39.996 µM 0.624295243197633 0.302336265619969 no 1003 0.266216853646791 1333 627608
SGTC_484 loperamide 105 µM 0.623275310886346 0.302681301592009 no 1004 0.266551809568769 1289 3955 An opioid-receptor agonist.
SGTC_2178 5812956 200 µM 0.623096316842265 0.302741872218145 no 1005 0.266610614970606 1296 5403383
SGTC_398 bronopol 33.3 µM 0.623048335101874 0.302758109904885 no 1006 0.266626379657549 1266 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1399 3562-5772 25 µM 0.622903169644085 0.302807238285203 no 1007 0.266674077504153 1269 23847490
SGTC_544 k015-0020 52.4 µM 0.622708499125225 0.302873126278101 no 1008 0.266738048282758 1310 3008304
SGTC_598 3937-0236 20.2 µM 0.622448471741868 0.302961144902203 no 1009 0.266823508111467 1330 1379313
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.621352053672648 0.303332405533343 no 1010 0.26718400571623 1476 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1057 3448-5381 134 µM 0.620312008583298 0.303684765378937 no 1011 0.267526195182977 1335 5497911
SGTC_2459 5811157 9.22 µM 0.619896299344281 0.303825655785963 no 1012 0.267663031158925 1278 2870684 YBR192W RIM2
SGTC_2721 ifenprodil 61.44 µM 0.619881967234035 0.303830513683749 no 1013 0.267667749384021 1318 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_309 k408-0051 1.48 µM 0.619656737051749 0.303906860460453 no 1014 0.267741902148653 1297 3640463
SGTC_2621 lithochol-11-enic acid 100 µM 0.618425717073079 0.304324293126156 no 1015 0.268147374936288 1316 6708711
SGTC_1973 st070275 50.2 µM 0.618320831279795 0.304359871169731 no 1016 0.268181936451592 1274 17118334
SGTC_2133 5320837 200 µM 0.618178063615146 0.304408302002247 no 1017 0.268228984240146 1326 2841355
SGTC_2780 5215298 71.43 µM 0.616939783746513 0.304828505400507 no 1018 0.268637222268855 1306 2834131
SGTC_2447 5741742 33.78 µM 0.616426246649463 0.305002846954066 no 1019 0.268806617521899 1379 1776504
SGTC_1269 0831-0796 3.05 µM 0.616321849638057 0.305038294282938 no 1020 0.268841060461548 1308 927758
SGTC_1062 mesoridazine 14.2 µM 0.616268078815798 0.305056552531047 no 1021 0.268858801538952 1325 4078 A neuroleptic.
SGTC_2663 amphotericin b 100 µM 0.614710009796743 0.305585816052532 no 1022 0.269373124062998 1300 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1688 st021091 57.6 µM 0.613553719801142 0.305978861322987 no 1023 0.269755136947628 1321 3656366
SGTC_991 3996-0057 64.7 µM 0.61338656089234 0.306035700362347 no 1024 0.269810385026554 1326 715343
SGTC_2023 5144124 124 µM 0.613137540937746 0.306120383272208 no 1025 0.269892699695214 1315 2830192
SGTC_3075 9116269 49.47 µM 0.613085974744598 0.306137920412152 no 1026 0.269909746703805 1346 17015205 YNL244C SUI1
SGTC_535 2293-4129 48.2 µM 0.612879482254534 0.306208150867659 no 1027 0.269978015417989 1349 396118 YIL048W NEO1
SGTC_3198 9112019 49.47 µM 0.6116319441624 0.306632604248742 no 1028 0.270390649111611 1365 45595555
SGTC_451 chloral hydrate 100 µM 0.610597111139575 0.306984885312104 no 1029 0.270733167833263 1373 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_750 4073-0104 132 µM 0.610018273250027 0.307182012871381 no 1030 0.270924851448074 1203 22330957
SGTC_1216 1165-0504 9.65 µM 0.609413133483896 0.307388157322958 no 1031 0.271125317374139 1330 6304004
SGTC_331 k048-0133 24.5 µM 0.60924383947681 0.307445839228559 no 1032 0.271181412995235 1301 6813582
SGTC_787 4152-0075 138 µM 0.608324293954156 0.307759230214588 no 1033 0.271486205726371 1359 9566539
SGTC_2904 7225135 42.03 µM 0.60693486753469 0.30823302778364 no 1034 0.27194706874327 1396 4446116
SGTC_2925 9010536 32.5 µM 0.606791779830692 0.30828183918515 no 1035 0.271994552024566 1382 2994177
SGTC_1404 3909-7820 48.3 µM 0.605703483886325 0.30865319966294 no 1036 0.272355835079987 1317 23741373
SGTC_1486 3970-0793 4.53 µM 0.605507667596553 0.308720039074327 no 1037 0.272420865771248 1357 2844330
SGTC_3049 9092223 49.47 µM 0.604382499920892 0.309104223582164 no 1038 0.272794683942 1312 8623917
SGTC_2566 crystal violet carbinol 226 nM 0.602449369004408 0.309764771820172 no 1039 0.273437528002919 1267 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_508 roscovitine 141 µM 0.602211703542134 0.309846024267469 no 1040 0.273516613103245 1397 160355 A CDKinase inhibitor.
SGTC_1465 k213-0056 144 µM 0.60042153506129 0.310458340696331 no 1041 0.274112669662716 1304 24048857 YMR208W ERG12
SGTC_3191 9110352 49.47 µM 0.599639773625401 0.310725902516773 no 1042 0.27437316701111 1361 17122424
SGTC_1442 4112-3290 3 µM 0.598331732965966 0.311173809960286 no 1043 0.274809303425514 1311 704353
SGTC_901 1112-0062 60.1 µM 0.597974478030251 0.31129619209247 no 1044 0.274928481348442 1348 1908457
SGTC_60 0986-0278 202 µM 0.597829472197128 0.311345871600921 no 1045 0.274976861616718 1163 3110598
SGTC_2624 nerol 100 µM 0.596596808186471 0.311768325302035 no 1046 0.275388301380461 1330 637566 A natural product oil.
SGTC_1616 st002734 56.1 µM 0.596119449120401 0.311931990497318 no 1047 0.275547716070212 1343 4026101
SGTC_2414 st077232 92.9 µM 0.594546069887529 0.312471695074919 no 1048 0.276073469225391 1309 729801
SGTC_2293 7624732 200 µM 0.594430744315522 0.312511270193613 no 1049 0.276112025252104 1294 894453
SGTC_2095 5432005 200 µM 0.593919905054756 0.31268659577052 no 1050 0.276282842504237 1337 783734
SGTC_2996 9066192 71.4286 µM 0.591497246085935 0.313518655318381 no 1051 0.277093649906239 1313 6472854
SGTC_339 3091-4833 71.4 µM 0.591196534333504 0.313622000784727 no 1052 0.277194372290827 1339 3240077
SGTC_834 0312-0008 75.7 µM 0.589481308158751 0.314211751257559 no 1053 0.277769223704954 1367 6385573 YIL048W NEO1
SGTC_3330 9141424 71.43 µM 0.588602797775193 0.314513995577929 no 1054 0.27806387832853 1388 27261020
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.587705076530016 0.314822977710429 no 1055 0.278365133761878 1379 66535 A nucleotide analog.
SGTC_1212 0520-0165 585 µM 0.587237830522839 0.314983848074937 no 1056 0.278521994125736 1548 5403258
SGTC_1380 2291-0730 164 µM 0.584456738980769 0.315942088859731 no 1057 0.279456531392812 1333 2999191
SGTC_2514 salinomycin 42.74 µM 0.584324765456218 0.315987591901288 no 1058 0.279500916612387 1429 23682228 A polyether potassium ionophore.
SGTC_1845 st056753 3.01 µM 0.582660271669119 0.31656173046568 no 1059 0.280061011356573 1291 5375839
SGTC_2496 diffractaic acid 79.83 µM 0.582480840211026 0.316623648700363 no 1060 0.280121421711264 1463 94870 An apoptosis inducer which activates caspases.
SGTC_1114 scopoletin 1.73284 µM 0.580523616284342 0.317299381264879 no 1061 0.280780782803911 1398 5280460 A coumarin with genotoxic properties.
SGTC_580 1123-0028 41 µM 0.58046084206414 0.317321064195376 no 1062 0.280801942967447 1406 1677248 YPR107C YTH1
SGTC_2180 6301957 200 µM 0.58018935092842 0.317414847543969 no 1063 0.280893467069271 1328 845462
SGTC_1019 4262-0212 3.4 µM 0.580021094210618 0.317472975688143 no 1064 0.280950196397323 1404 4677213
SGTC_3015 9080845 49.47 µM 0.579204661890512 0.317755094857475 no 1065 0.281225542792234 1441 5296973
SGTC_299 1273-0059 1.44 µM 0.577121569685759 0.318475389099693 no 1066 0.281928667140053 1355 2848077
SGTC_1348 1493-0373 93.8 µM 0.576819324201795 0.318579957028883 no 1067 0.282030757016191 1396 3010129
SGTC_3085 9117376 49.47 µM 0.576580524920857 0.318662584682306 no 1068 0.282111429168103 1428 16480349
SGTC_1951 sophoraflavanone G 9.2 µM 0.5736894643589 0.319663643608141 no 1069 0.283088979511712 1364 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3344 9148862 3.898 µM 0.572610527714624 0.320037573743814 no 1070 0.283454214964486 1438 4905352
SGTC_1395 3486-0190 4.35 µM 0.570843053707721 0.320650527318741 no 1071 0.284053017752834 1455 6748079
SGTC_1136 pergolide 1.05886 µM 0.570598380788843 0.320735417597639 no 1072 0.284135958187057 1387 47811 A dopamine receptor agonist.
SGTC_304 1310-0298 97 µM 0.570179412789369 0.320880802044139 no 1073 0.284278008918645 1326 1550234
SGTC_2988 9073640 71.4286 µM 0.570096798085164 0.320909473092634 no 1074 0.28430602336781 1424 9102229
SGTC_2833 9001315 45.46 µM 0.568545204079301 0.321448144799741 no 1075 0.284832410150183 1427 2989378
SGTC_1359 1582-0056 520 nM 0.567462336461148 0.3218243100056 no 1076 0.2852000542299 1431 3661189
SGTC_2974 9094440 9.66 µM 0.565249741304294 0.32259348623991 no 1077 0.28595195407589 1498 25236134
SGTC_1768 st044301 37.178 µM 0.563905936208342 0.323061011487416 no 1078 0.286409074945206 1357 3931349
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.562295340510442 0.323621724712655 no 1079 0.286957406218034 1454 688761
SGTC_2592 piperlongumine 83.33 µM 0.557677067542614 0.325231749651723 no 1080 0.288532459971937 1337 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3324 9138759 60.749 µM 0.557296160982651 0.325364687798268 no 1081 0.288662549110365 1425 45595710
SGTC_2648 atorvastatin 78.68 µM 0.556937793698267 0.325489779924642 no 1082 0.288784965736392 1426 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2377 9073351 62.6 µM 0.555851590704867 0.325869051333282 no 1083 0.289156156941517 1366 7337946 YHR072W ERG7
SGTC_894 0960-0238 55.9 µM 0.555666357253587 0.325933747625486 no 1084 0.289219479673237 1395 6741907 YDL195W SEC31
SGTC_2753 fluvastatin 17.09 µM 0.555183372195772 0.326102463952639 no 1085 0.289384620529966 1429 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_370 0180-0345 38.7 µM 0.555145717164872 0.32611561910347 no 1086 0.289397497290776 1384 3989527
SGTC_423 5-fluorouracil 457 µM 0.555004654984521 0.326164902470093 no 1087 0.289445738230079 1331 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2264 7948757 110.76 µM 0.5549270318796 0.326192023209419 no 1088 0.289472285662869 1370 2971411
SGTC_2033 5192550 145 µM 0.554453036203081 0.326357652515113 no 1089 0.289634419012705 1371 182073
SGTC_509 pifithrin 175 µM 0.554070398663834 0.326491383338589 no 1090 0.289765333796379 1493 4817 A p53 inhibitor.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.554027047025925 0.326506536030014 no 1091 0.289780167783261 1451 65057 A dermal irritant. YDR527W RBA50
SGTC_649 1123-0311 367 µM 0.553713784500597 0.32661603913994 no 1092 0.289887369988887 1385 693629 YIL048W NEO1
SGTC_691 1548-0686 185 µM 0.553689260150773 0.326624612428883 no 1093 0.289895763301516 1364 46495133
SGTC_2316 5844804 197.44 µM 0.553621225565284 0.326648396623715 no 1094 0.289919048329744 1440 776813
SGTC_32 0928-0142 34.1 µM 0.552365556618809 0.327087492052611 no 1095 0.290348961952214 1379 2244242
SGTC_1944 st076371 56.9 µM 0.550798816283322 0.327635701932735 no 1096 0.290885797852638 1377 24208455
SGTC_1453 4237-0541 195 µM 0.550293783170073 0.327812494709995 no 1097 0.291058943796194 1407 739892
SGTC_1516 st013856 110 µM 0.548452338340431 0.328457440829029 no 1098 0.291690673591831 1395 5281404 A mutagen and neurotoxin.
SGTC_2053 5265679 138 µM 0.548429344196362 0.328465497516201 no 1099 0.29169856604783 1367 764595
SGTC_450 aminopyrene 156 nM 0.544889961510647 0.329706575310009 no 1100 0.292914600410786 1448 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1012 4112-3522 18 µM 0.544078378792191 0.329991420351241 no 1101 0.293193769110137 1434 3112398
SGTC_578 3460-0051 92 µM 0.543573951811976 0.330168511179642 no 1102 0.293367344339262 1458 2876744
SGTC_1635 st007035 42.4 µM 0.541784132218668 0.330797175830741 no 1103 0.293983611892681 1453 3716403
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.541686680722236 0.33083141887611 no 1104 0.294017183397051 1436 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2594 a-mangostin 100 µM 0.541231363548858 0.330991429494648 no 1105 0.294174061138454 1508 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1753 st043925 64 µM 0.540980564251846 0.331079580257237 no 1106 0.294260489565517 1455 670181
SGTC_2431 5490079 200 µM 0.539900375061367 0.331459351366652 no 1107 0.294632869611929 1416 5722345
SGTC_1999 st074831 12.5 µM 0.539700981950433 0.331529472627707 no 1108 0.29470163134517 1387 17112523
SGTC_2677 mitomycin C 100 µM 0.538875223708458 0.331819932711281 no 1109 0.294986477054568 1426 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1111 tnp00062 510.699 nM 0.538054876814574 0.332108589490898 no 1110 0.295269581652635 1532 676306
SGTC_930 2810-3379 265 µM 0.537525212810468 0.33229501616916 no 1111 0.295452436973416 1571 1015764
SGTC_1776 st049249 45.9 µM 0.537098461024226 0.332445250864929 no 1112 0.29559980189992 1407 1822314
SGTC_1731 st035964 63 µM 0.534014795385988 0.33353163055555 no 1113 0.296665648874974 1454 6739575
SGTC_172 1112-0046 2.638 µM 0.533043688193239 0.333874042756635 no 1114 0.297001669173071 1442 2802135 YIL048W NEO1
SGTC_2720 fluspirilene 36.88 µM 0.532848719096892 0.333942805509021 no 1115 0.297069152914653 1451 3396 An atypical antipsychotic.
SGTC_1896 st058441 89 µM 0.53274641023209 0.333978890581987 no 1116 0.29710456740854 1373 688759
SGTC_3302 9125395 16.351 µM 0.532609098882172 0.334027323696014 no 1117 0.297152101142404 1471 17599668
SGTC_2826 7992541 19.48 µM 0.532074462539307 0.334215929505853 no 1118 0.297337211903643 1482 2985066
SGTC_1272 0839-0021 27 µM 0.530605491620652 0.334734359707466 no 1119 0.297846094683947 1433 5027250
SGTC_1786 berberine 21.6 µM 0.530557189608823 0.334751411843359 no 1120 0.297862834271055 1392 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1906 st060206 94.7 µM 0.529058378874741 0.335280708571575 no 1121 0.298382476463886 1437 5133468
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.52729587156296 0.335903546844075 no 1122 0.298994070375328 1498 5024745
SGTC_3300 9124615 50.48 µM 0.523888587428383 0.337108896881752 no 1123 0.300178016524529 1517 24824903
SGTC_590 k048-0076 22.4 µM 0.523313198435221 0.337312610240428 no 1124 0.300378158868081 1502 6832814
SGTC_443 clozapine 122 µM 0.523275116598571 0.337326094592249 no 1125 0.300391407317482 1429 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_181 1447-1644 8.07 µM 0.523072192688452 0.337397951198719 no 1126 0.300462007816369 1447 534600
SGTC_236 1509-0011 5.31 µM 0.522133458876495 0.337730439762823 no 1127 0.300788705929165 1472 3107280
SGTC_3036 9090181 49.47 µM 0.522022616645027 0.337769707155038 no 1128 0.300827291815854 1482 25236586
SGTC_2344 7990960 76.95 µM 0.521908599313073 0.337810101212995 no 1129 0.300866985333463 1461 140813
SGTC_307 1501-1223 22.3 µM 0.5204452414918 0.338328705300684 no 1130 0.301376642186583 1439 2830329
SGTC_774 k060-0086 136 µM 0.520271918386096 0.338390150176079 no 1131 0.301437032725706 1489 5911235
SGTC_2386 9075165 157.42 µM 0.520245335995568 0.338399574295521 no 1132 0.301446295243702 1418 16452277
SGTC_1713 st033146 12.748 µM 0.518062897010638 0.339173648087239 no 1133 0.302207193121646 1547 674619
SGTC_3228 9131799 49.47 µM 0.516501108017809 0.33972800517534 no 1134 0.302752232633447 1486 17015818
SGTC_254 nsc-64875 3.808 µM 0.515741487303896 0.339997758042497 no 1135 0.303017487228354 1582 56993
SGTC_3217 9129673 49.47 µM 0.514240312563662 0.340531088872291 no 1136 0.303541993206217 1453 17248312
SGTC_810 3825-7150 143 µM 0.514042402814896 0.34060142521221 no 1137 0.303611172521802 1599 22330411 YGL099W LSG1
SGTC_3347 9188721 44.724 µM 0.512380619528416 0.341192234887733 no 1138 0.304192326025595 1470 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_887 0885-0007 9.62 µM 0.510494937345374 0.341863118545331 no 1139 0.304852380251438 1531 5719458
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.508790182507806 0.342470062462912 no 1140 0.305449650803524 1482 7104
SGTC_73 0327-0325 16.231 µM 0.508384805094798 0.342614448954716 no 1141 0.305591753407435 1485 53298
SGTC_1423 4048-0112 5.59 µM 0.507902973798455 0.342786096545938 no 1142 0.305760694552232 1537 X1423
SGTC_2121 5257820 149.641 µM 0.507680617160279 0.342865319827897 no 1143 0.305838671854098 1511 791256
SGTC_2922 7999257 32.47 µM 0.507646498835952 0.342877476431959 no 1144 0.305850637442929 1438 2988377
SGTC_2049 5262831 67.185 µM 0.506831063562581 0.343168070258332 no 1145 0.306136679228651 1482 763417
SGTC_255 tunicamycin 200.472 nM 0.506345169227638 0.343341270848525 no 1146 0.306307179498957 1482 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3060 1327-0027 12.5 µM 0.505810198313758 0.343532003204034 no 1147 0.306494949257889 1465 16000455 YPR107C YTH1
SGTC_678 1218-2179 85.9 µM 0.505337129206673 0.343700699003452 no 1148 0.306661034402583 1499 6820081 YOR116C RPO31
SGTC_1013 4112-3890 241 µM 0.503994997316537 0.344179470749999 no 1149 0.307132446232111 1433 705171
SGTC_2776 terbinafine 19.92 µM 0.50266601150164 0.34465379919297 no 1150 0.3075995549348 1460 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_675 1309-0189 238 µM 0.502145237366287 0.344839735407921 no 1151 0.307782680520655 1437 4246530
SGTC_1587 estradiol valerate 56.1 µM 0.501895457057683 0.344928929800456 no 1152 0.30787053053837 1506 13791 A steroid.
SGTC_2461 5755302 26.15 µM 0.501383942812603 0.345111614013268 no 1153 0.3080504691415 1579 2788904
SGTC_29 0299-0004 12.984 µM 0.500040687121123 0.345591521438913 no 1154 0.308523214347102 1415 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2236 dapsone 200 µM 0.499564434560287 0.345761732722414 no 1155 0.308690902909426 1475 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1317 1273-0028 910 nM 0.497911925047919 0.346352576434309 no 1156 0.309273060871484 1461 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2251 lansoprazole 556 µM 0.497509263698575 0.346496602041145 no 1157 0.309414985967887 1415 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2404 5161160 200 µM 0.497349537747978 0.346553739641025 no 1158 0.309471292074765 1524 2831543
SGTC_392 N-ethylmaleimide 8.33 µM 0.495702305594496 0.347143195440413 no 1159 0.310052230088231 1458 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_405 ebelactone b 50 µM 0.495259006764961 0.34730189149637 no 1160 0.310208651703201 1474 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_221 trifluoperazine 10.304 µM 0.495003512435302 0.347393367792485 no 1161 0.310298820568995 1473 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2874 9043904 71.43 µM 0.493133314437298 0.348063237324736 no 1162 0.310959196419626 1471 4463428
SGTC_2558 carylophyllene oxide 100 µM 0.49264055414489 0.348239813784168 no 1163 0.311133293926682 1544 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1075 aripiprazole 15.2 µM 0.492255373288194 0.348377862981264 no 1164 0.311269411897915 1481 60795 An atypical antipschotic. YIL048W NEO1
SGTC_946 3434-1334 87.4 µM 0.49163664032896 0.348599659524964 no 1165 0.311488118210363 1568 4047976
SGTC_3343 9148379 18.9835 µM 0.4913312388402 0.348709155556493 no 1166 0.311596094374462 1630 1955036
SGTC_2714 st079313 56.9 µM 0.49071012725449 0.348931882452755 no 1167 0.311815741339251 1496 2939799
SGTC_2034 5197015 53.07 µM 0.489464629601759 0.349378667259321 no 1168 0.312256394925713 1581 780676
SGTC_86 0417-1630 471.922 µM 0.488888449708431 0.349585425130029 no 1169 0.312460336701345 1519 3634867
SGTC_1459 k035-0031 35.7 µM 0.487085063034056 0.350232845219488 no 1170 0.313099025605729 1394 3877128 YMR208W ERG12
SGTC_1759 st043059 70 µM 0.485732599805519 0.350718668598859 no 1171 0.313578383484403 1460 669426
SGTC_374 0880-0231 82.3 µM 0.485517548601995 0.350795940470431 no 1172 0.313654633816029 1482 6833587
SGTC_2582 agaric acid 100 µM 0.485189771841883 0.350913728589957 no 1173 0.313770868367246 1393 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2460 5552655 174.22 µM 0.484830936222934 0.351042694285736 no 1174 0.313898138052205 1457 5401989
SGTC_1198 1612-1005 86.7 µM 0.482869998206864 0.351747759117285 no 1175 0.314594022709373 1575 6998509
SGTC_3092 9117248 49.47 µM 0.482790872716373 0.351776219798272 no 1176 0.314622116088527 1594 17141857
SGTC_1168 k815-0004 80.5 µM 0.482746365306937 0.35179222905215 no 1177 0.314637918844863 1467 642433
SGTC_626 0214-0009 33 µM 0.481262283779122 0.352326201452832 no 1178 0.315165049622152 1594 3437874
SGTC_1309 pyrazolanthrone 13.4 µM 0.479877254438716 0.352824797639571 no 1179 0.315657337841494 1605 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2481 5478948 45.16 µM 0.478486715357913 0.353325631680309 no 1180 0.316151913676507 1493 77792
SGTC_1313 1220-0047 237 µM 0.477117795066215 0.353818927464452 no 1181 0.316639121857858 1561 3528706
SGTC_2162 5663267 200 µM 0.476485208438921 0.354046965526933 no 1182 0.316864371383203 1601 6456493
SGTC_798 1287-0182 476 µM 0.476468491261255 0.354052992531093 no 1183 0.316870324906328 1629 1649755
SGTC_1760 st045453 10.4495 µM 0.475656642131402 0.354345730540632 no 1184 0.317159507466298 1563 3323419 YIL048W NEO1
SGTC_2795 7780010 54.55 µM 0.475384068989404 0.354444034761233 no 1185 0.317256623709954 1528 953673
SGTC_53 0973-0023 39.979 µM 0.474285726323808 0.354840253140434 no 1186 0.317648084357333 1541 674768
SGTC_1123 mangostin 811.285 nM 0.473477896001556 0.35513177177352 no 1187 0.317936133615119 1492 5281650 An antioxidant.
SGTC_144 4161-2749 112.381 µM 0.473284655510368 0.355201518306012 no 1188 0.318005054002406 1445 797501 YMR168C CEP3
SGTC_3079 9117512 49.47 µM 0.472990522003334 0.35530768959203 no 1189 0.318109970591499 1582 7185044
SGTC_1868 st057644 42.7 µM 0.472150874960436 0.355610832800706 no 1190 0.318409550601749 1498 688665
SGTC_296 1222-0039 74.9 µM 0.472143712154235 0.355613419228243 no 1191 0.318412106750586 1463 5984176
SGTC_499 genistein 192 µM 0.472126980578998 0.355619460881646 no 1192 0.318418077683851 1585 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3159 9100096 49.47 µM 0.469114803404964 0.356707726495971 no 1193 0.31949378917127 1449 25236875
SGTC_1591 genipin 88.4 µM 0.468758289497779 0.35683660838019 no 1194 0.319621208566422 1569 442424 A DNA cross-linking agent.
SGTC_403 arphamenine a 50 µM 0.468660619024193 0.356871919686174 no 1195 0.319656120073428 1570 5487158 An arginine aminopeptidase inhibitor.
SGTC_1203 3992-3522 103 µM 0.468477769599778 0.356938029470825 no 1196 0.31972148239159 1746 5322312
SGTC_253 dyclonine 31.25 µM 0.468225448555635 0.357029263992758 no 1197 0.319811687594852 1589 3180 An oral anasthetic.
SGTC_3257 9139206 32.98 µM 0.467980644477611 0.357117788336595 no 1198 0.319899215656182 1565 4910041
SGTC_1522 st012842 45.6 µM 0.467658471071664 0.357234302159801 no 1199 0.3200144218857 1442 3491067 YOR116C RPO31
SGTC_1945 st075991 56.6 µM 0.46753066741102 0.357280525967314 no 1200 0.320060128101909 1474 1084980
SGTC_583 1488-1091 88.9 µM 0.466798338144292 0.35754543391877 no 1201 0.320322082475961 1594 4303273
SGTC_463 ikarugamyin 104 µM 0.465888505473331 0.357874646394466 no 1202 0.320647654611226 1576 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1926 methyl fluorone black 53.6 µM 0.465765346988058 0.357919218004839 no 1203 0.320691735932014 1427 72721 Reacts with homocysteine.
SGTC_1245 0418-0076 17.2 µM 0.465043746805601 0.358180407264918 no 1204 0.320950064417658 1564 6790114
SGTC_1812 st052057 4.327 µM 0.463938216321441 0.358580692053979 no 1205 0.321346005756402 1488 3645418
SGTC_2752 diclazuril 33.15 µM 0.463822442610793 0.358622619800503 no 1206 0.321387481406148 1574 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2272 7805186 180 µM 0.46332147788911 0.35880406509402 no 1207 0.321566976461403 1539 2956062 YPR165W RHO1
SGTC_1718 roemerine 11.9335 µM 0.463212530847769 0.358843529034655 no 1208 0.32160601757215 1496 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2055 5235184 200 µM 0.462659745567073 0.359043787930983 no 1209 0.321804138218086 1540 2836034
SGTC_832 4083-0019 164 µM 0.462470227657664 0.359112453975293 no 1210 0.321872073927694 1668 1990758
SGTC_2611 pyromycin 23.93 µM 0.462365689093135 0.3591503322893 no 1211 0.32190954998751 1500 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1196 1588-0294 184 µM 0.461919747960041 0.35931192933827 no 1212 0.32206943589279 1493 6144269
SGTC_1997 st073024 93.8 µM 0.461689626462571 0.359395329014507 no 1213 0.322151955596677 1535 686268
SGTC_519 k048-0011 62.8 µM 0.460633257648946 0.35977825970848 no 1214 0.322530873342101 1574 6836379
SGTC_3279 9140807 49.47 µM 0.459415745347518 0.360219779107999 no 1215 0.322967821740152 1534 45595718
SGTC_943 3253-1379 105 µM 0.458223933271348 0.360652159215407 no 1216 0.323395783471384 1611 668464
SGTC_341 1486-1430 230 µM 0.458000378167826 0.360733283125201 no 1217 0.323476084788512 1480 2054753 YPL210C SRP72
SGTC_2907 7721985 69.9 µM 0.457838223004162 0.360792130082455 no 1218 0.323534336303486 1483 3267881
SGTC_2702 st077768 96.8 µM 0.456539379676487 0.361263605951522 no 1219 0.324001079875535 1505 6484119
SGTC_2869 9037858 32.47 µM 0.456163546931202 0.361400071361871 no 1220 0.324136188266343 1469 27187042
SGTC_2822 7994718 71.43 µM 0.455996834439224 0.36146061055497 no 1221 0.324196127280797 1571 1018011
SGTC_534 k292-0788 63.4 µM 0.45498690388411 0.361827426109572 no 1222 0.324559330264537 1656 4146317
SGTC_2892 9047358 58.44 µM 0.454551113866325 0.361985748070236 no 1223 0.324716105718421 1512 6466771
SGTC_1014 4130-3005 69.3 µM 0.452325648143168 0.362794624722479 no 1224 0.325517200770388 1518 743608
SGTC_724 3910-0327 137 µM 0.451441620913344 0.363116107001035 no 1225 0.325835645808854 1517 2885483
SGTC_1787 fluconazole 80 µM 0.449439602962674 0.363844510211245 no 1226 0.326557283995992 1492 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1722 st034304 3.6505 µM 0.447587757245251 0.364518713984645 no 1227 0.327225370189786 1516 4036148 YLR033W RSC58
SGTC_3077 9117319 49.47 µM 0.447547033418504 0.364533545078344 no 1228 0.327240068264671 1565 17154678
SGTC_99 0109-0120 622.8 µM 0.446308604330553 0.364984661770972 no 1229 0.32768717089616 1642 759414
SGTC_1504 k297-0033 30 µM 0.446099856154893 0.365060719907676 no 1230 0.327762558358719 1490 4388117
SGTC_55 0767-0285 6.563 µM 0.445712678938731 0.365201803350493 no 1231 0.327902402394739 1538 3116166
SGTC_3296 9122258 64.045 µM 0.444329741640106 0.365705880508543 no 1232 0.328402100665356 1566 4730474
SGTC_70 0141-0289 43.283 µM 0.444105781643841 0.365787535210731 no 1233 0.328483053298129 1649 352408
SGTC_410 α-linolenic acid 100 µM 0.444020441489783 0.36581865140723 no 1234 0.328513902489119 1629 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.443592408319917 0.365974731514523 no 1235 0.328668647718246 1506 6708514
SGTC_2421 5690543 90.72 µM 0.443115149726705 0.366148787576548 no 1236 0.328841223877266 1587 3397993
SGTC_2259 7964009 200 µM 0.442422328870388 0.36640150813934 no 1237 0.329091812047016 1605 313134
SGTC_1457 k015-0032 57.3 µM 0.437061435793221 0.368358954742521 no 1238 0.331033396988019 1556 4302660
SGTC_1726 st035556 14.5795 µM 0.436365941970129 0.368613155305597 no 1239 0.331285622646639 1663 5919439
SGTC_2656 pseudo-anisatin 100 µM 0.436163143594438 0.368687288236985 no 1240 0.331359183305173 1600 6708809 A neurotoxin.
SGTC_2226 7298446 200 µM 0.436032556933413 0.368735026768066 no 1241 0.331406554193715 1639 3283010
SGTC_3166 9102297 49.47 µM 0.433919677661625 0.369507712535221 no 1242 0.332173384922733 1532 25237072
SGTC_513 4245-1575 41.7 µM 0.432991889547586 0.369847174014463 no 1243 0.332510330983619 1661 719745
SGTC_1403 3909-7815 62.9 µM 0.430900207842867 0.370612855646342 no 1244 0.333270466165859 1620 6615483
SGTC_2412 st077135 33.4 µM 0.430686739164447 0.370691026941452 no 1245 0.33334808111665 1667 13258915
SGTC_1809 st050081 57.6 µM 0.430551645501947 0.370740500407388 no 1246 0.333397203428886 1641 5036894
SGTC_1146 3579-1023 7 µM 0.430229479200382 0.370858491498586 no 1247 0.333514360007857 1677 X1146
SGTC_3274 9138298 49.47 µM 0.427672421195508 0.371795425495377 no 1248 0.334444815688579 1550 17015756
SGTC_2568 diosmetin 100 µM 0.425834849803332 0.372469201312995 no 1249 0.335114095417214 1604 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1102 cgs 12066b 26.1 µM 0.425599600319386 0.372555487650468 no 1250 0.335199815785919 1595 6438352 A 5-HT1B full agonist.
SGTC_2808 7946468 45.46 µM 0.425370200040631 0.37263963473861 no 1251 0.335283413082725 1623 2970879
SGTC_1957 st077035 62.4 µM 0.425090909359945 0.372742090498373 no 1252 0.335385202287754 1626 705593
SGTC_6 0844-0013 19.835 µM 0.424300175945428 0.373032214124452 no 1253 0.335673455464838 1658 1584900
SGTC_1233 0325-0408 14.2 µM 0.42398308171733 0.37314857765486 no 1254 0.335789075861447 1665 12874
SGTC_2159 5658611 73.75 µM 0.423865765160102 0.373191632045798 no 1255 0.335831856319316 1651 793844
SGTC_1017 4239-0030 168 µM 0.423692562007915 0.373255199337345 no 1256 0.335895020177392 1509 1149593
SGTC_1267 0828-0272 9.49 µM 0.423612079246903 0.373284738490771 no 1257 0.335924372269784 1709 745334
SGTC_1056 3448-1962 115 µM 0.42042907631408 0.374453574369526 no 1258 0.337086015412887 1626 715507
SGTC_1943 st076331 65.2 µM 0.420263414882899 0.37451443888677 no 1259 0.337146516547401 1641 24208415
SGTC_2930 9013230 14.89 µM 0.419406434977067 0.374829345823997 no 1260 0.337459561009133 1702 2995857
SGTC_415 dibenzyl ketone 100 µM 0.418631859501259 0.375114044155555 no 1261 0.337742600952247 1700 7593
SGTC_2649 anisomycin 9.56 µM 0.418061521509289 0.375323717690419 no 1262 0.337951068552011 1593 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_771 0250-0039 27.3 µM 0.417778459577262 0.375427793519931 no 1263 0.33805455064877 1606 3005115
SGTC_1475 4092-1048 11.7 µM 0.415939948033651 0.3761039953549 no 1264 0.338726973329567 1585 2881759
SGTC_412 gemfibrozil 100 µM 0.415252721021458 0.376356854258298 no 1265 0.338978453960249 1627 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1514 1189-1591 158 µM 0.41505961108243 0.376427916853669 no 1266 0.339049132628364 1683 767698 YMR146C TIF34
SGTC_3318 9139014 38.6185 µM 0.414413247307187 0.376665802949933 no 1267 0.339285744414378 1617 16643984
SGTC_1241 0364-0022 50.8 µM 0.414368247643219 0.376682366257989 no 1268 0.339302219621353 1659 4563895
SGTC_3 0833-0587 95.581 µM 0.414031962469343 0.376806152032506 no 1269 0.339425349550349 1592 5382644
SGTC_1191 1487-1166 10.6 µM 0.413983709115218 0.376823915017028 no 1270 0.339443018795454 1682 3955771
SGTC_661 1304-0007 33.6 µM 0.412450229722833 0.377388553798754 no 1271 0.34000472660273 1576 3117130
SGTC_2977 9011197 71.43 µM 0.411191699907577 0.37785215001089 no 1272 0.340465986966445 1659 2704722
SGTC_3203 9113543 49.47 µM 0.40900927988143 0.378656490326906 no 1273 0.341266425496156 1672 17018012
SGTC_24 0417-1663 219 µM 0.408403949637775 0.378879680714369 no 1274 0.34148856710851 1601 4329390
SGTC_2085 5307070 144.047 µM 0.408114444796625 0.378986437884793 no 1275 0.341594827828544 1574 2840351
SGTC_467 ro 31-8220 72.8 µM 0.407578972494838 0.37918392180037 no 1276 0.34179140226135 1696 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2399 5884133 200 µM 0.403967886955275 0.380516522815919 no 1277 0.34311816693885 1569 722445
SGTC_2876 9059903 25.97 µM 0.402875315245054 0.380919995559287 no 1278 0.34351997579547 1618 6916095
SGTC_2593 nobiletin 86.24 µM 0.402066348031465 0.381218820269828 no 1279 0.343817599052324 1584 72344 An anti-infammatory.
SGTC_2145 5634607 200 µM 0.401450831455295 0.381446233639082 no 1280 0.344044115678693 1571 308662
SGTC_1714 st033236 13.627 µM 0.401207620679234 0.381536103403579 no 1281 0.344133635256647 1724 2916566
SGTC_1085 doxorubicin 7.67 µM 0.400133844971947 0.381932954747692 no 1282 0.344528968602675 1735 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_830 4076-0286 57.8 µM 0.400104191208906 0.381943916095095 no 1283 0.344539888678186 1655 6866659
SGTC_2875 9039966 71.43 µM 0.399703650089449 0.382091983145629 no 1284 0.344687401680009 1729 6463691
SGTC_2629 bisabolol 100 µM 0.399589339803511 0.382134243112159 no 1285 0.34472950469543 1705 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2274 7947094 46.08 µM 0.399433692142805 0.382191787566289 no 1286 0.344786836275519 1580 2971028
SGTC_3255 9139072 49.47 µM 0.398611304073578 0.382495875605145 no 1287 0.345089815535251 1632 17646060
SGTC_1706 st031321 9.9705 µM 0.396704512630683 0.383201213564079 no 1288 0.345792686038447 1716 6103185
SGTC_2685 mycophenolic acid 18.85 µM 0.396095054847255 0.383426738855875 no 1289 0.346017453135465 1687 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1043 0916-0009 19.3 µM 0.395859352731628 0.383513969257433 no 1290 0.346104394270227 1813 3101130
SGTC_1828 st055811 49 µM 0.395689154479356 0.383576961170869 no 1291 0.346167178679538 1741 5877589
SGTC_1094 duloxetine 25.4 µM 0.395128210449586 0.383784593408317 no 1292 0.346374135168831 1639 60834 A selective serotonin reuptake inhibitor.
SGTC_2437 5741531 144.16 µM 0.394598742351023 0.383980605511779 no 1293 0.346569520914887 1756 2262990
SGTC_2164 5685496 200 µM 0.394587023009398 0.383984944414697 no 1294 0.346573846079941 1718 759046
SGTC_2299 7976368 114.88 µM 0.392396534936606 0.384796193180656 no 1295 0.347382622950474 1741 2979718
SGTC_1489 4065-0444 182 µM 0.392344710870937 0.384815392383709 no 1296 0.347401765981674 1744 2877968
SGTC_1469 k284-2957 126 µM 0.389252327290311 0.385961533941241 no 1297 0.348544749044811 1677 23884841
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.389239279272623 0.385966372093609 no 1298 0.348549574675988 1775 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1969 st069479 40.1 µM 0.389182372955894 0.385987472933836 no 1299 0.34857062098672 1715 3895485
SGTC_166 k072-0058 166.424 µM 0.387893166614966 0.38646560041251 no 1300 0.349047547623209 1704 5846229
SGTC_2122 5258151 111.688 µM 0.386704783893631 0.386906488221948 no 1301 0.349487387072658 1610 2173356
SGTC_1232 0279-0259 161 µM 0.384049402992047 0.387892156386206 no 1302 0.350470915806889 1620 1560000
SGTC_1259 0671-0132 43 µM 0.38329813213943 0.388171156964049 no 1303 0.350749362019838 1640 X1259
SGTC_3158 9100007 49.47 µM 0.383032757023104 0.388269723520824 no 1304 0.35084773812528 1604 19297233
SGTC_1780 st038448 24.544 µM 0.382433720119743 0.388492246358073 no 1305 0.351069841359453 1751 728868 YDL195W SEC31
SGTC_1596 piperlongumine 63 µM 0.381681721510343 0.388771641328549 no 1306 0.351348729806474 1757 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1559 coumarin 343 70.1 µM 0.380746404973878 0.389119225889722 no 1307 0.351695715783917 1719 108770 A hepatotoxic, DNA x-linker.
SGTC_1930 st074634 34.3 µM 0.379249181553298 0.389675812273254 no 1308 0.352251416486311 1569 684253 YOR116C RPO31
SGTC_2881 9058953 51.95 µM 0.378823880904442 0.389833957293239 no 1309 0.352409326200772 1573 17122249
SGTC_548 1436-0017 110 µM 0.378743990806694 0.389863665893271 no 1310 0.352438991403796 1777 9677137
SGTC_1678 st019265 80.2 µM 0.376502094953036 0.390697617809835 no 1311 0.353271829162809 1816 5367020
SGTC_2586 curcumin 80 µM 0.375167998215425 0.391194120939104 no 1312 0.353767764303177 1755 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2442 5158906 48.48 µM 0.37370011273734 0.391740620375257 no 1313 0.354313720721469 1755 1893835
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.373249053978186 0.391908594266823 no 1314 0.354481544995604 1652 442882
SGTC_655 k060-0012 42 µM 0.370590395722319 0.392899084725757 no 1315 0.355471318300127 1638 5994525
SGTC_3313 9133968 57.047 µM 0.369773333952982 0.393203623027828 no 1316 0.35577569279471 1681 1494643
SGTC_2200 6600604 21.907 µM 0.3681128909379 0.393822710731271 no 1317 0.356394529590299 1658 2904777
SGTC_3128 9127691 49.47 µM 0.367638120862171 0.39399977575123 no 1318 0.356571543072536 1679 41316314
SGTC_3022 9087993 49.47 µM 0.366826091646552 0.394302672000402 no 1319 0.356874372000665 1716 17173644
SGTC_2125 5246583 200 µM 0.366691319525602 0.39435294974414 no 1320 0.356924641114593 1845 835267
SGTC_1401 3807-4679 7.6 µM 0.365614769443121 0.394754627894146 no 1321 0.357326276324316 1664 3291456
SGTC_837 0091-0265 12.5 µM 0.365527142081456 0.394787328002828 no 1322 0.357358974971339 1649 759367
SGTC_1322 1348-1070 12 µM 0.365164785567963 0.394922557302919 no 1323 0.357494201477584 1709 6758089
SGTC_2952 9073731 13.78 µM 0.364221050579149 0.395274812980496 no 1324 0.357846474450719 1616 16457353
SGTC_1137 ixabepilone 100 µM 0.363720915838444 0.395461526484488 no 1325 0.358033211516668 1620 154225 A novel microtubule stabilizer.
SGTC_326 k292-0812 17.5 µM 0.360542149309234 0.396648803254933 no 1326 0.359220871196593 1804 3579357
SGTC_671 0560-0003 407 µM 0.359922188421547 0.396880472185867 no 1327 0.359452661763889 1760 3238678
SGTC_861 0443-0273 110 µM 0.358466481136885 0.397424588391554 no 1328 0.359997123830027 1738 6149169
SGTC_2991 9074669 71.4286 µM 0.358070794738707 0.397572523135954 no 1329 0.360145167193363 1753 17333109
SGTC_37 0566-0070 1.56 µM 0.356769151071937 0.398059270747723 no 1330 0.360632316173616 1799 1626686
SGTC_302 1094-0063 18.9 µM 0.356608853170565 0.398119224887225 no 1331 0.360692324415133 1692 5440289
SGTC_150 3970-0969 77.2 µM 0.353479010583519 0.399290319553532 no 1332 0.361864680796869 1727 6615640
SGTC_2878 9043973 25.97 µM 0.353421436923335 0.399311870443393 no 1333 0.361886258555927 1785 6465167
SGTC_2622 2-methoxyxanthone 59.94 µM 0.353238254668861 0.399380441002994 no 1334 0.361954915484896 1833 71034 A hepatoprotective.
SGTC_2285 7945142 200 µM 0.351819013236328 0.399911810272693 no 1335 0.362486999276437 1687 2970608
SGTC_286 k060-0067 22.9 µM 0.350946746202703 0.40023848234183 no 1336 0.362814150356643 1698 5985051
SGTC_2304 7443016 91.4 µM 0.350864506428181 0.400269285502537 no 1337 0.362845000245488 1677 939854
SGTC_921 1561-0023 372 µM 0.350021855307733 0.400584938786008 no 1338 0.363161147862492 1644 24050882
SGTC_1471 k673-0312 37 µM 0.349253171255819 0.400872940982534 no 1339 0.363449625704582 1742 24099884
SGTC_1848 st056003 16.4 µM 0.348842148141587 0.401026960781135 no 1340 0.363603909506833 1796 146492
SGTC_633 0437-0093 97.7 µM 0.348025679008676 0.401332956121843 no 1341 0.363910449261999 1680 2831118
SGTC_1721 st082152 9.2685 µM 0.34578152265902 0.402174329662741 no 1342 0.364753456182061 1661 5296051
SGTC_3154 9100113 49.47 µM 0.343678251470249 0.402963294663328 no 1343 0.365544134397361 1666 25237525
SGTC_1725 st036284 20.55 µM 0.343440719235577 0.403052421062803 no 1344 0.365633465368045 1857 707914
SGTC_1437 4092-1038 11.6 µM 0.343260361305562 0.403120097991543 no 1345 0.365701299130708 1706 3977136
SGTC_3244 9134489 49.47 µM 0.342259993825279 0.403495525298569 no 1346 0.366077619885917 1674 16584271
SGTC_3131 9127911 49.47 µM 0.340790520612265 0.404047164215817 no 1347 0.366630643605806 1735 45595681
SGTC_148 3253-0744 288.01 µM 0.338412462648655 0.40494028896916 no 1348 0.367526191876504 1664 6893655
SGTC_3200 9114385 49.47 µM 0.33836297428991 0.40495888053837 no 1349 0.367544836276035 1648 17018030 YLR208W SEC13
SGTC_351 caspofungin 25 nM 0.338167976522947 0.405032138530358 no 1350 0.367618303384816 1775 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_298 1391-0729 10 µM 0.337966611481003 0.405107792113245 no 1351 0.367694174504535 1720 3237558
SGTC_2832 7992762 51.95 µM 0.33747665342751 0.405291885952853 no 1352 0.367878804406189 1528 2985177
SGTC_629 3448-6466 76.7 µM 0.337288474835141 0.405362596597236 no 1353 0.367949723481279 1725 573744
SGTC_1611 st001856 99.4 µM 0.33693229057857 0.405496446091289 no 1354 0.368083971359508 1683 647478
SGTC_2087 5276107 200 µM 0.336756513846701 0.405562504815734 no 1355 0.368150228551066 1689 144405
SGTC_1693 xanthone 101.9 µM 0.336434390565369 0.405683569075855 no 1356 0.368271659714641 1780 7020 An insecticide.
SGTC_933 2914-0560 114 µM 0.336415571345634 0.405690642221244 no 1357 0.368278754423371 1878 463887
SGTC_881 0833-0569 170 µM 0.336073253914558 0.405819306538219 no 1358 0.368407813438011 1654 5418700
SGTC_3295 9122362 53.5725 µM 0.335778515959915 0.405930095661991 no 1359 0.368518946143896 1698 4730473
SGTC_540 1187-0821 17.3 µM 0.33431695047655 0.406479595028342 no 1360 0.369070200475848 1669 847520
SGTC_1870 st057514 26.5 µM 0.33425783791321 0.406501823243289 no 1361 0.369092501462349 1704 5393161
SGTC_1064 honokiol 6.76 µM 0.332910479612063 0.407008554630955 no 1362 0.369600929326063 1736 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.332567779601787 0.407137466415375 no 1363 0.36973028415718 1749 688788
SGTC_2279 7948423 32.93 µM 0.330409002255117 0.407949753856425 no 1364 0.370545470162429 1899 1247112
SGTC_170 4197-0004 226 µM 0.327907119337684 0.408891637293987 no 1365 0.371490945320681 1799 218692
SGTC_3221 9128209 49.47 µM 0.326959801514935 0.409248411555909 no 1366 0.371849144695711 1736 16460723
SGTC_790 1575-0012 79.1 µM 0.325897757545783 0.409648482808655 no 1367 0.372250856189536 1861 378741 YLR208W SEC13
SGTC_997 3996-0078 137 µM 0.324375563113042 0.410222056420075 no 1368 0.37282685911232 1742 735687
SGTC_2606 farnesol 9.78 µM 0.323790570872335 0.410442536796547 no 1369 0.373048297661416 1840 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_474 dl-dihydrosphingosine 5 µM 0.323637530026837 0.410500221728566 no 1370 0.373106235513629 1804 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2937 9044753 11.33 µM 0.323443357923091 0.410573412849678 no 1371 0.373179748873338 1701 6465530 YGL099W LSG1
SGTC_1915 st067105 30.6 µM 0.323100203197733 0.410702769008332 no 1372 0.37330967818942 1693 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2778 tioconazole 65.09 nM 0.321048046913366 0.411476555414629 no 1373 0.374086990181414 1695 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_584 0986-0246 15.4 µM 0.319895991428048 0.411911100816538 no 1374 0.374523588356411 1804 53315 YDR232W HEM1
SGTC_1152 3909-8331 15.9 µM 0.316909723719899 0.413037997020924 no 1375 0.375656051793327 1736 16001939
SGTC_2105 5350118 200 µM 0.316447536840608 0.413212471886138 no 1376 0.375831420050788 1726 2133313
SGTC_306 1672-3436 11.6 µM 0.315384537872223 0.413613817424021 no 1377 0.376234852620775 1800 6797378
SGTC_375 3970-0961 9.27 µM 0.314780713935059 0.413841837217141 no 1378 0.376464077971325 1774 2898222
SGTC_357 1325-0123 420 µM 0.313628191845148 0.41427714044324 no 1379 0.376901722559932 1878 1098503
SGTC_1441 4106-0040 13 µM 0.311688899645479 0.415009841209788 no 1380 0.377638482403445 1764 2904180
SGTC_362 0310-0100 9.03 µM 0.308022858029793 0.41639574607547 no 1381 0.379032469601778 1744 790235
SGTC_2540 epiandrosterone 100 µM 0.307828946401581 0.41646908124715 no 1382 0.379106247176166 1772 441302 A steroid.
SGTC_460 trequinsin 123 µM 0.307186678600476 0.416712000373302 no 1383 0.379350642300179 1793 5537 A vasodilator.
SGTC_880 0833-0487 87.2 µM 0.306142331802917 0.417107062062644 no 1384 0.379748139051427 1730 76075
SGTC_1065 prochlorperazine maleate 2.48 µM 0.305782839640189 0.417243072273625 no 1385 0.379884997515991 1766 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_66 0109-0187 42.4 µM 0.304885460583892 0.417582629713347 no 1386 0.380226694837314 1661 759417
SGTC_250 brefeldin a 552.239 µM 0.304793565624429 0.417617405134115 no 1387 0.380261691198217 1772 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_16 erodoxin 22.806 µM 0.302327249682175 0.418550962482162 no 1388 0.381201303712094 1799 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1853 st056710 91.2 µM 0.30226913404088 0.41857296614507 no 1389 0.381223452974793 1929 269167
SGTC_479 n-linoleoylglycine 10 µM 0.301486140005994 0.418869447066049 no 1390 0.381521908661149 1764 6433346 An anti-infammatory.
SGTC_3025 9087895 49.47 µM 0.299555952590505 0.419600509585274 no 1391 0.382257943357649 1878 17173641
SGTC_2365 9042475 200 µM 0.29947329937752 0.419631820878113 no 1392 0.382289470872726 1764 6464479
SGTC_1660 st012960 28.1 µM 0.299141174528798 0.419757643963483 no 1393 0.382416165540394 1790 24207266
SGTC_1466 k213-0079 57.5 µM 0.297034212594073 0.420556041757126 no 1394 0.383220194677959 1785 3657981
SGTC_1513 0337-0559 19 µM 0.295987914416646 0.420952640550559 no 1395 0.383619655498142 1714 775073
SGTC_2378 9074213 121.43 µM 0.294834104976314 0.421390084444402 no 1396 0.384060305929112 1762 657714
SGTC_382 3229-0966 23.2 µM 0.293299159292999 0.421972178899427 no 1397 0.384646748097719 1874 5722370
SGTC_1026 k007-1105 30.6 µM 0.291625672151616 0.422607006410677 no 1398 0.385286422349212 1778 7066794
SGTC_2662 daunorubicin 22.37 µM 0.288527661432173 0.423782748031279 no 1399 0.386471429804962 1793 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1941 st076221 61.8 µM 0.287890659658201 0.424024584258327 no 1400 0.386715218447702 1928 2828568
SGTC_850 0388-0143 75.9 µM 0.287685186026193 0.424102597947707 no 1401 0.386793865349403 1789 67273
SGTC_2303 7774051 200 µM 0.287521128906882 0.424164888859731 no 1402 0.386856663042165 1886 2953184
SGTC_1681 tripelennamine 100 µM 0.286549944260028 0.424533677091597 no 1403 0.387228473180385 1783 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.285853612647878 0.424798135990133 no 1404 0.387495121789358 1807 91467 include heat shock
SGTC_2993 9054257 71.4286 µM 0.285359683459151 0.424985745258696 no 1405 0.387684295943829 1788 6470217 YGL055W OLE1
SGTC_481 bay k-8644 50 µM 0.285138489385113 0.425069766979488 no 1406 0.387769021596722 1767 2303 A calcium channel antagonist.
SGTC_143 4032-1194 15.74 µM 0.283187723657093 0.425810922461482 no 1407 0.388516469225517 1766 1806963
SGTC_2796 7949634 45.45 µM 0.283113170957788 0.425839252526817 no 1408 0.388545042751587 1756 2971588
SGTC_2196 6573537 42.6665 µM 0.27913818396457 0.427350300401966 no 1409 0.390069390348408 1923 2903087
SGTC_956 1185-0240 191 µM 0.2788741065104 0.427450724581618 no 1410 0.390170720265241 1823 1416193
SGTC_2894 9048625 32.47 µM 0.278647370440781 0.427536952216772 no 1411 0.390257727767021 1931 4092861
SGTC_2787 5284540 71.43 µM 0.27843176137299 0.427618951468542 no 1412 0.390340470502089 1785 736958
SGTC_3227 9130768 49.47 µM 0.276839204664256 0.428224720463198 no 1413 0.390951788106687 1875 17720899
SGTC_2 0422-0095 29 µM 0.276566966100978 0.428328290218245 no 1414 0.391056316413987 1823 6790840
SGTC_2729 fluphenazine 10.66 µM 0.275582674239857 0.428702792883216 no 1415 0.39143430924741 1793 3372 An atypical antipsychotic.
SGTC_705 1124-0212 310 µM 0.274266472344364 0.429203680716465 no 1416 0.391939924068221 1953 9554485
SGTC_2536 dehydroabietamide 32.04 µM 0.274119369155334 0.42925966873822 no 1417 0.391996444652412 1924 3983547
SGTC_3055 9094636 49.47 µM 0.273695731028976 0.429420914934122 no 1418 0.392159229341557 1867 25236176
SGTC_1179 1021-1431 9.29 µM 0.273358788752823 0.429549171149607 no 1419 0.392288714272341 1842 2840958
SGTC_637 1181-0519 7.26 µM 0.272743811883344 0.429783279685195 no 1420 0.392525076998989 1823 6252091 YGR060W ERG25
SGTC_1283 0922-0125 16.4 µM 0.272675414894893 0.42980931848252 no 1421 0.392551367429002 1882 3360884
SGTC_1670 st016595 4.04 µM 0.272643895757062 0.429821317950479 no 1422 0.392563482918219 1928 597879
SGTC_2046 4110841 106 µM 0.270646652841031 0.430581808448218 no 1423 0.39333140533008 1951 44119630 YMR134W ERG29
SGTC_1808 st050063 61.5 µM 0.2702823009153 0.430720570645522 no 1424 0.393471540320388 1915 4011993
SGTC_2585 alliin 100 µM 0.269825027435984 0.430894733804378 no 1425 0.393647433803612 1889 87310 A garlic compound which reacts with lipids.
SGTC_1817 st052116 64.4 µM 0.269427592560556 0.431046116968166 no 1426 0.393800327574517 1897 4361398
SGTC_1623 st003709 20.3 µM 0.268810484845901 0.4312811937081 no 1427 0.394037762244124 1775 16192618
SGTC_2945 9067681 61.76 µM 0.267448487601551 0.431800109547551 no 1428 0.394561935435622 1871 16456930
SGTC_1330 1469-0054 61.8 µM 0.267445767695058 0.431801145939774 no 1429 0.394562982400081 1969 7102664
SGTC_282 k297-0036 65.7 µM 0.267388122377193 0.431823111202019 no 1430 0.394585171797527 1884 5061378
SGTC_3301 9125354 19.7965 µM 0.266905971085195 0.432006839133796 no 1431 0.394770779558325 1794 41905162
SGTC_1899 st063254 59.6 µM 0.26516653063898 0.432669789956525 no 1432 0.395440588469241 1758 3093813
SGTC_2233 sulbentine 40.3845 µM 0.264945076567065 0.432754206120625 no 1433 0.395525886331531 1890 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1751 st044839 27.194 µM 0.264499880932237 0.432923919701326 no 1434 0.395697378273195 1940 5291326
SGTC_2877 9040724 71.43 µM 0.262694195463324 0.433612393842863 no 1435 0.396393145528391 1987 6463895
SGTC_1571 st070080 73.4 µM 0.262580712530222 0.433655669516515 no 1436 0.396436883852804 1906 4315245
SGTC_193 1273-0060 1.558 µM 0.261766544991144 0.433966168116707 no 1437 0.396750716571848 1933 2847393 YHR072W ERG7
SGTC_217 ketoconazole 989 nM 0.261276460716206 0.434153090930378 no 1438 0.396939658947007 1875 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3008 9078912 71.4286 µM 0.260753945208292 0.434352399542378 no 1439 0.397141131196391 1822 16648731
SGTC_2321 7390090 138.78 µM 0.259761322263259 0.434731072123488 no 1440 0.397523943687344 1777 649046
SGTC_2687 chenodiol 100 µM 0.259375982081906 0.434878090482146 no 1441 0.397672579640742 1860 5702181 A cholesterol synthesis inhibitor.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.258623173448158 0.435165334581703 no 1442 0.397963000790829 1815 2724 A muscle relaxant with antifungal properties.
SGTC_1264 0783-0040 158 µM 0.257499278502721 0.435594235206115 no 1443 0.398396686101582 1768 2855798
SGTC_2652 actinonin 100 µM 0.256678803649151 0.435907392575995 no 1444 0.398713367848124 1897 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2171 5739187 198.077 µM 0.25658341405574 0.435943803316337 no 1445 0.398750190057993 1802 2262761
SGTC_445 e6 berbamine 66 µM 0.255933713547716 0.436191812053591 no 1446 0.399001010854104 1848 6610268 A calcium/calmodulin antagonist.
SGTC_1092 toremifene 6.32 µM 0.255664157000547 0.436294716647655 no 1447 0.399105087031626 1903 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_918 glabranin 770.725 nM 0.254953244749885 0.436566131709359 no 1448 0.399379605677722 1886 124049 Also referred to as licorice root.
SGTC_2888 9058547 12.99 µM 0.254938625860803 0.436571713284001 no 1449 0.39938525128188 1813 16476514
SGTC_1555 citronellol 128 µM 0.254849410107431 0.436605776637552 no 1450 0.399419705575311 1989 8842 A terpine precursor.
SGTC_89 0302-0250 142.109 µM 0.254601639678353 0.436700380015442 no 1451 0.399515396316561 1922 4203518 YLR208W SEC13
SGTC_1529 apigenin 74 µM 0.254102054210341 0.436891142082819 no 1452 0.399708358208175 1975 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1131 3454-3128 32.3 µM 0.251379028970138 0.437931160811772 no 1453 0.400760539857434 1922 710982
SGTC_114 0364-0001 490.298 µM 0.250958626848828 0.438091765508469 no 1454 0.400923048348767 1805 4003655
SGTC_1949 st076024 69.1 µM 0.250059455477154 0.438435306881789 no 1455 0.401270684950561 1755 2921930
SGTC_2253 7938677 135.83 µM 0.249769655338149 0.438546039097388 no 1456 0.401382743817463 1986 2301972
SGTC_420 mitomycin C 81.9 mM 0.249081684525524 0.438808931004419 no 1457 0.401648798345239 1851 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3030 9087619 49.47 µM 0.248850870105637 0.438897137374346 no 1458 0.401738069941975 1834 25236973
SGTC_2397 5161689 200 µM 0.247597760754608 0.43937606943243 no 1459 0.402222821725059 1921 2259942
SGTC_2868 9035608 32.47 µM 0.245861344801416 0.440039865385367 no 1460 0.402894783921469 1827 6462614
SGTC_1252 0493-0875 34.8 µM 0.245150980607975 0.44031147163831 no 1461 0.403169765084184 1838 3960963
SGTC_2020 4017018 200 µM 0.244526328953429 0.44055032909567 no 1462 0.403411606597922 1853 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1640 st009078 66.4 µM 0.243253008214305 0.44103729482004 no 1463 0.40390470257767 1947 690618
SGTC_630 4356-0227 183 µM 0.242653972608083 0.441266419444095 no 1464 0.404136733185345 1903 779312
SGTC_1665 st014639 11.4 µM 0.242392029157785 0.441366616155803 no 1465 0.404238205033612 1917 981133 YIL048W NEO1
SGTC_347 4534-1311 26.2 µM 0.241828222923159 0.441582291957021 no 1466 0.404456634561263 1862 2862016
SGTC_2044 5102272 200 µM 0.241630132155961 0.441658072788561 no 1467 0.404533385860421 1879 592666
SGTC_2564 betulinic acid 100 µM 0.240899317064605 0.441937669012643 no 1468 0.40481657572915 2060 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1583 clindamycin 39.6 µM 0.240189348487682 0.442209317454772 no 1469 0.405091735350403 1795 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1189 1431-2119 7.28 µM 0.24009139934449 0.442246796928768 no 1470 0.405129700786285 1898 3107275
SGTC_2902 5787006 60.46 µM 0.239943775162276 0.442303285144749 no 1471 0.405186922130519 1836 591003
SGTC_1108 betulinic acid 729.144 nM 0.239237251280744 0.442573651882504 no 1472 0.405460809413105 1857 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_966 1300-0360 30.2 µM 0.239021846852207 0.442656086400608 no 1473 0.405544321161263 1850 70588
SGTC_488 nitrendipine 139 µM 0.23798999695374 0.443051006101494 no 1474 0.405944426306559 1951 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1460 k062-0059 9.15 µM 0.237754200183139 0.443141260507813 no 1475 0.406035871534332 1817 1373085
SGTC_589 1227-0070 34.1 µM 0.236916111490103 0.443462074147385 no 1476 0.406360935306426 1921 2841384
SGTC_740 k014-0057 261 µM 0.236482112589994 0.443628220029061 no 1477 0.406529292895603 1984 4012779
SGTC_1735 st034310 56.75 µM 0.235935278546406 0.44383757619607 no 1478 0.406741446284098 1944 871153
SGTC_2756 carbadox 75.1 µM 0.234757486723487 0.444288548581484 no 1479 0.407198483160552 1869 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.233772886895183 0.444665603810234 no 1480 0.407580649758069 1899 4620898
SGTC_2959 9079155 11 µM 0.23296128358593 0.444976447210901 no 1481 0.407895734942172 1908 16189457
SGTC_920 mycophenolic acid 780.421 nM 0.231235388604645 0.445637575822313 no 1482 0.40856596937787 1849 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1105 epirubicin 18.1 µM 0.228898343038546 0.446533055007259 no 1483 0.409473964223467 1855 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_204 PMA1.184 62.41 µM 0.228238913605045 0.446785776261174 no 1484 0.40973025550269 1916 2252213 YGL008C PMA1
SGTC_1992 st073643 23.3 µM 0.227904191750206 0.44691406411112 no 1485 0.409860361964029 1881 3161292
SGTC_1884 5633444 25 µM 0.22783018030722 0.446942431007224 no 1486 0.409889131569249 1924 5724239
SGTC_3253 9135987 49.47 µM 0.22686069656428 0.447314037002436 no 1487 0.410266032421511 1952 4182430
SGTC_1000 4048-0884 8.67 µM 0.225582766803518 0.447803941891799 no 1488 0.410762972742024 1921 13040088
SGTC_1789 tunicamycin 25 nM 0.224585603588073 0.448186267964915 no 1489 0.411150832740321 2017 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3206 9114350 49.47 µM 0.223236627104729 0.448703560615769 no 1490 0.411675673406946 2012 17087243
SGTC_281 1672-3440 14.9 µM 0.222065271093114 0.449152811842266 no 1491 0.412131536272507 2009 6833000
SGTC_1844 rapamycin 4 nM 0.221268982147963 0.449458250517791 no 1492 0.412441500036579 1916 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1483 3453-0561 55.9 µM 0.219069724841586 0.450301991599143 no 1493 0.413297867014903 1988 4546991
SGTC_1310 1188-0297 994 nM 0.218738537501089 0.450429070580052 no 1494 0.413426863628362 1975 1588352
SGTC_3298 9116858 71.43 µM 0.218401851087049 0.450558264804853 no 1495 0.413558011696023 1990 2506942
SGTC_1413 3910-0535 34.4 µM 0.217388126446128 0.45094728555496 no 1496 0.413952941841726 2010 2876951
SGTC_2038 4100038 30.985 µM 0.216697153218777 0.451212476231931 no 1497 0.414222183348713 1945 3596803
SGTC_3165 9101544 49.47 µM 0.216219523039744 0.451395800079873 no 1498 0.414408318140945 1986 5002184
SGTC_1625 st003711 30.1 µM 0.215258825580706 0.451764565997747 no 1499 0.414782764768017 1991 24207034 YER133W GLC7
SGTC_1126 isoteolin 1.0172 µM 0.214971250002257 0.451874960650685 no 1500 0.414894866853202 1855 133323
SGTC_316 k060-0003 58.6 µM 0.21445816952028 0.452071931472744 no 1501 0.41509489197564 2004 6152314
SGTC_3112 9123419 49.47 µM 0.212488543546869 0.452828177060459 no 1502 0.415862957323615 2069 17015854
SGTC_2636 apigenin dimethyl ether 100 µM 0.211840783400504 0.453076924629334 no 1503 0.416115624979283 1953 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_789 1309-1135 70.6 µM 0.211571144106702 0.453180474745341 no 1504 0.416220811680003 1972 3092424
SGTC_2320 7373003 200 µM 0.211322548476654 0.453275946241987 no 1505 0.416317794532123 1866 5415828
SGTC_2082 5219693 150 µM 0.21124532938869 0.453305602268602 no 1506 0.416347920505273 1934 2834649
SGTC_2366 9070441 60.58 µM 0.210689696124852 0.453519001150168 no 1507 0.416564707718445 1903 6837235
SGTC_644 1498-1197 63.3 µM 0.20966454130829 0.453912761663655 no 1508 0.416964751155976 1993 6741615
SGTC_1287 0971-0001 34.6 µM 0.208427906292733 0.454387811676314 no 1509 0.417447434345791 1947 4665869
SGTC_2575 plumbagin 510 nM 0.208258855020392 0.454452757352452 no 1510 0.417513428095692 1859 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3138 9097216 49.47 µM 0.208257338308761 0.454453340044278 no 1511 0.417514020195739 2109 25237486
SGTC_1747 st037496 66.6 µM 0.20811274181782 0.454508891722008 no 1512 0.417570469219839 1930 723305
SGTC_2790 5423970 71.43 µM 0.207766757515394 0.454641817011453 no 1513 0.417705544924644 2018 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1390 3413-2614 145 µM 0.204081110524143 0.456058134881573 no 1514 0.419145057656997 1912 3421432
SGTC_2375 9072683 200 µM 0.202670163893886 0.456600481293363 no 1515 0.419696422473762 2084 16798029
SGTC_3122 9126309 49.47 µM 0.202669345508071 0.456600795891975 no 1516 0.419696742325584 2090 17591206
SGTC_1952 st077036 64.1 µM 0.202195547262686 0.45678293492736 no 1517 0.419881927005803 2085 2937007
SGTC_54 0159-0055 9 µM 0.201586476502519 0.45701708918808 no 1518 0.420120009187029 2078 3319099
SGTC_1766 st045414 44.774 µM 0.201286566611313 0.457132393560525 no 1519 0.42023725294793 1963 253960
SGTC_1234 0326-0494 15.5 µM 0.201195152236272 0.457167539758823 no 1520 0.420272990973608 2033 1547813
SGTC_2984 9022109 38.96 µM 0.200319575792472 0.457504190653558 no 1521 0.420615326777789 2108 6459207
SGTC_237 nikkomycin 200 µM 0.200045103273861 0.457609729040703 no 1522 0.420722653334735 2057 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.197930159897005 0.458423053013256 no 1523 0.42154985338787 1994 5355888
SGTC_770 0389-1121 67.2 µM 0.197065829923381 0.458755490605828 no 1524 0.421888011413507 2060 6753108
SGTC_2923 7992654 58.14 µM 0.196736977552783 0.458881981011728 no 1525 0.422016685829839 1932 2985126
SGTC_3050 9093513 49.47 µM 0.196566808127838 0.458947436940726 no 1526 0.422083273540788 1987 25236664
SGTC_262 fenpropimorph 62.5 µM 0.196231515501391 0.459076411016532 no 1527 0.422214480879366 1985 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2557 derrustone 83.84 µM 0.196204369873758 0.459086853075854 no 1528 0.422225103935169 1878 629853 An antioxidant.
SGTC_931 2812-0076 566 µM 0.195380561297548 0.459403759419517 no 1529 0.422547516598218 1896 3450959
SGTC_673 1082-0474 110 µM 0.19526944593754 0.459446505748772 no 1530 0.422591007618164 1933 3098046
SGTC_142 0335-0849 62.6745 µM 0.194497675313227 0.459743420556131 no 1531 0.4228931079023 1986 3889043 YPR107C YTH1
SGTC_958 1222-0007 33 µM 0.194445090502393 0.459763651749808 no 1532 0.422913693243247 2011 7312461
SGTC_471 1-acyl-paf 4 µM 0.192875702816441 0.460367497142609 no 1533 0.423528157036571 1901 16759367
SGTC_441 propafenone 146 µM 0.192366806847516 0.460563322174701 no 1534 0.423727445550783 1988 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_884 0851-0618 334 µM 0.192237436852218 0.460613105749267 no 1535 0.423778111186925 2056 9642473
SGTC_718 1130-0073 349 µM 0.191816264814675 0.460775183534166 no 1536 0.423943065029767 2015 6740020
SGTC_2109 5483026 200 µM 0.19149333974699 0.460899457784308 no 1537 0.424069549051364 1954 759335
SGTC_77 0828-0286 12.516 µM 0.190511806203117 0.461277213838983 no 1538 0.424454046297198 2092 745345
SGTC_2576 guaiol 23.12 µM 0.189716717288282 0.461583239865429 no 1539 0.424765560108754 2100 227829
SGTC_2954 9074818 52.69 µM 0.188721660836815 0.46196626449486 no 1540 0.425155486876685 2004 16648742
SGTC_823 0417-1665 178 µM 0.187903325864924 0.46228129061098 no 1541 0.425476217758206 1972 3429856
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.186376237907073 0.462869221303325 no 1542 0.4260748626752 1985 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3056 9094900 49.47 µM 0.185800893671306 0.463090750631215 no 1543 0.426300451844237 1904 25236784
SGTC_743 1275-0778 158 µM 0.185300472685459 0.46328344097972 no 1544 0.426496683650331 2077 2849257 YMR203W TOM40
SGTC_909 3448-9333 149 µM 0.183702590407564 0.463898773371911 no 1545 0.427123388322047 1920 3344074
SGTC_648 0375-0473 33.3 µM 0.183551989367448 0.463956773171154 no 1546 0.427182464998255 1984 1713139
SGTC_1027 k015-0025 8.67 µM 0.18306671810655 0.464143667096342 no 1547 0.427372834767188 1938 3598955
SGTC_2136 5328288 199.296 µM 0.182175826208128 0.464486799438444 no 1548 0.427722371712205 1960 262395
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.181743051030794 0.464653494933718 no 1549 0.427892189361955 1986 1377
SGTC_138 0850-0259 40.9225 µM 0.181628375398405 0.464697666510174 no 1550 0.427937189437663 2079 6813004
SGTC_1290 0986-0249 10.2 µM 0.181542371423396 0.46473079441905 no 1551 0.42797093903069 2089 53329
SGTC_2258 7960471 200 µM 0.179679853036775 0.4654482782834 no 1552 0.428701955480207 1935 2974708
SGTC_2507 purpurin 79.67 µM 0.178671881538707 0.465836618512411 no 1553 0.429097674574865 1883 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1104 tacrolimus 29.8 µM 0.178439420667066 0.465926183123364 no 1554 0.429188946416225 2008 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1770 st043884 66.3 µM 0.17762914487285 0.466238386916321 no 1555 0.429507117110681 2087 670149
SGTC_528 3492-0019 172 µM 0.177480782426889 0.466295554052188 no 1556 0.429565379503524 2096 2869262
SGTC_2517 totarol 10 µM 0.174743159817826 0.467350540554321 no 1557 0.430640726432193 1924 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3184 9108758 49.47 µM 0.1744064835361 0.467480300114613 no 1558 0.430773009642703 2028 902885
SGTC_1302 1159-0335 255 µM 0.173832097213349 0.467701684286572 no 1559 0.430998709239171 1976 649284
SGTC_2173 5763948 167 µM 0.172778835653161 0.46810766595682 no 1560 0.431412636767493 2106 2867177
SGTC_2464 5717415 7.67 µM 0.172689968753457 0.46814192139556 no 1561 0.431447564551682 1918 5285744
SGTC_600 1495-0418 41.6 µM 0.172153201124012 0.468348833706143 no 1562 0.43165854429691 2009 5377768
SGTC_3339 9145883 14.936 µM 0.171609350842354 0.468558484946079 no 1563 0.431872327805262 2087 2030670
SGTC_2487 5918373 44.05 µM 0.170902578388614 0.468830954792053 no 1564 0.432150184615627 2150 2876279
SGTC_3116 9124943 49.47 µM 0.170641574073679 0.468931579001059 no 1565 0.432252802974441 1892 41905195 YPL160W CDC60
SGTC_2539 epi(13)torulosol 80 µM 0.169648439273516 0.469314477363302 no 1566 0.432643312815637 1966 6708597
SGTC_430 0958-0115 16.4 µM 0.169610366426351 0.469329156734163 no 1567 0.432658284725277 1944 6833180
SGTC_349 k015-0014 24 µM 0.167854960640655 0.470006016118581 no 1568 0.433348691748415 1951 2196908
SGTC_549 1661-1316 519 µM 0.167838488774881 0.470012367848156 no 1569 0.433355171155625 2125 2857282
SGTC_228 caffeine 993.056 µM 0.166299542919559 0.470605835452785 no 1570 0.433960612867757 2118 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_653 0203-0016 55.2 µM 0.165426595125826 0.470942501637113 no 1571 0.434304111081039 2053 295302
SGTC_2103 5378138 10 µM 0.16506244425612 0.471082948357471 no 1572 0.434447416313007 2070 244142
SGTC_764 1951-2361 146 µM 0.165033465665492 0.471094125055635 no 1573 0.43445882070286 1925 5438930
SGTC_613 3914-0030 117 µM 0.164645982910162 0.471243574735483 no 1574 0.434611317979652 2056 1145395
SGTC_3019 9081971 49.47 µM 0.164480831960533 0.471307273657865 no 1575 0.434676317559766 2104 16451803
SGTC_3078 9116413 49.47 µM 0.162927550528704 0.471906411892897 no 1576 0.435287739236295 2085 17177322
SGTC_1297 1068-0111 14.1 µM 0.161112545075944 0.472606583872961 no 1577 0.436002379891456 1999 767057
SGTC_1800 st050079 29.0735 µM 0.160736959616663 0.472751483565142 no 1578 0.4361502891705 2062 3645560
SGTC_1149 3909-7961 23.3 µM 0.160318304910147 0.472913003486888 no 1579 0.436315170069668 1957 735261
SGTC_2268 7933382 153.85 µM 0.159613937480309 0.473184763417855 no 1580 0.436592599613286 2146 935025 YOR257W CDC31
SGTC_978 1416-0512 87.4 µM 0.159501076263184 0.473228308838574 no 1581 0.436637055218881 2027 6814003
SGTC_1253 0550-0034 176 µM 0.159020342261502 0.473413794771054 no 1582 0.43682642347734 2013 5969915
SGTC_814 3342-0569 96 µM 0.158725960196177 0.473527381704749 no 1583 0.436942392091832 2107 4346283
SGTC_2141 5621638 7.665 µM 0.158556395980971 0.473592808812259 no 1584 0.437009192531327 2107 2856238
SGTC_2850 9015429 58.44 µM 0.157861691205634 0.473860871162167 no 1585 0.43728289273716 2032 6457570
SGTC_2680 butyl paraben 22.24 µM 0.157408106739915 0.474035899986338 no 1586 0.437461612423972 2128 7184 An antifungal and steroid mimetic.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.156157194475357 0.474518626915975 no 1587 0.437954558298082 2147 4114 Related to psoralen; DNA damaging agent.
SGTC_892 0929-0076 29 µM 0.156049952497401 0.474560013336799 no 1588 0.437996823540706 1989 5751038
SGTC_1284 0929-0043 16 µM 0.154518244511752 0.475151154069409 no 1589 0.438600563466043 2027 1239883
SGTC_2788 5282734 71.43 µM 0.15377289421364 0.475438831196361 no 1590 0.438894403442855 2112 743706
SGTC_3260 9137109 49.47 µM 0.151722520832612 0.47623026366306 no 1591 0.439702896876451 2140 17478346
SGTC_747 3448-8087 38.7 µM 0.151403165130555 0.476353541668038 no 1592 0.439828846416382 2019 5168703
SGTC_878 0828-0289 13.7 µM 0.149724950816041 0.477001404545937 no 1593 0.440490811084713 1994 745350 YLR208W SEC13
SGTC_2068 5226020 147 µM 0.149668084105386 0.477023358615684 no 1594 0.440513244846862 2017 1810509
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.149626492376628 0.47703941564122 no 1595 0.44052965279124 2148 551469
SGTC_1772 st048439 82.2 µM 0.147857141057841 0.477722530823519 no 1596 0.441227756413046 2008 2927068 YDL195W SEC31
SGTC_680 0417-1641 114 µM 0.146922572276009 0.478083377811621 no 1597 0.441596567581066 2028 2835990
SGTC_1511 0906-3109 28.5 µM 0.146756774680384 0.478147395919053 no 1598 0.441662001990731 2157 2882180
SGTC_1502 4534-4282 27.7 µM 0.146213604705789 0.478357129763593 no 1599 0.441876382989266 2046 3278949
SGTC_2260 7964312 200 µM 0.145189968278003 0.478752402030435 no 1600 0.442280443081613 2150 231951
SGTC_407 eburnamonine 100 µM 0.142119451768759 0.479938190977831 no 1601 0.443492826919834 2019 3195
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.141158374993321 0.480309381871672 no 1602 0.443872414343298 2056 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1301 naphtanilide LB 4.81 µM 0.141024622947836 0.480361041479347 no 1603 0.443925245216498 2154 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2992 9074591 71.4286 µM 0.140417162329732 0.480595667653154 no 1604 0.444165199306614 2182 17741321
SGTC_2059 5238311 157 µM 0.139176227031096 0.481074988502908 no 1605 0.444655446869224 2059 703021
SGTC_526 4469-0568 170 µM 0.13869515013444 0.481260815570103 no 1606 0.444845525345552 1988 2901964
SGTC_2587 piperic acid 92.2 µM 0.138677763909642 0.481267531477643 no 1607 0.444852395061197 2044 5370536
SGTC_713 1488-1073 324 µM 0.138046689905236 0.481511304753193 no 1608 0.445101758776428 2171 3312542
SGTC_3182 9108849 49.47 µM 0.137624156466889 0.481674526184612 no 1609 0.44526873154643 2078 17133045
SGTC_2846 9008642 19.48 µM 0.137419566625423 0.481753558779093 no 1610 0.445349582916804 2028 2992898
SGTC_1415 3966-0071 78.1 µM 0.137128920114741 0.481865836103107 no 1611 0.445464446724224 2155 2893185
SGTC_1767 st044992 70.3 µM 0.137033331798531 0.481902762374151 no 1612 0.445502224328444 2061 9600693
SGTC_2216 7189485 200 µM 0.136977682371467 0.481924260113056 no 1613 0.445524217851303 2153 731273
SGTC_809 3998-0021 90 µM 0.136226891018423 0.482214300852855 no 1614 0.445820958683516 2185 715485
SGTC_1047 2043-3044 82 µM 0.135984580273858 0.482307910750577 no 1615 0.445916735441872 2069 669592
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.135858506480224 0.482356616178409 no 1616 0.445966569145383 2203 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1162 k048-0130 20.1 µM 0.134482054073761 0.482888390796521 no 1617 0.446510700476483 2039 6797406
SGTC_385 1494-0393 12.4 µM 0.134419685658386 0.482912486756732 no 1618 0.446535357996651 2088 3090647
SGTC_2614 arthonioic acid 13.39 µM 0.134195053764437 0.482999273527967 no 1619 0.446624168530334 2161 6710684
SGTC_1993 st073995 70.8 µM 0.133616656363306 0.483222741676784 no 1620 0.446852856213043 2087 3098394
SGTC_841 0251-0215 91.2 µM 0.132613930229154 0.483610164843814 no 1621 0.447249357500831 2099 3888614
SGTC_1642 st009582 77.7 µM 0.13198244774384 0.483854158614866 no 1622 0.447499087480147 2177 6739311
SGTC_3043 9092303 49.47 µM 0.130647415709669 0.484370011399432 no 1623 0.448027115924612 2074 25236084
SGTC_2765 myclobutanil 7.74 µM 0.129998311650556 0.484620832966208 no 1624 0.448283881231938 2074 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3259 9138485 49.47 µM 0.128981512197917 0.485013748622592 no 1625 0.448686138875355 2162 17646153
SGTC_1620 st003704 16.5 µM 0.128341333561742 0.485261136465945 no 1626 0.448939428051712 2172 2834414
SGTC_2628 lathosterol 100 µM 0.127921450984359 0.485423397146519 no 1627 0.449105567540142 2098 6710616
SGTC_486 niguldipine 82 µM 0.127358906935216 0.485640792131604 no 1628 0.449328169420661 2169 1236 A calcium channel blocker.
SGTC_333 3486-0131 40.1 µM 0.127081616860131 0.485747952375216 no 1629 0.449437900553503 2181 6744690
SGTC_1573 oleylamine 1.06 µM 0.126406614119572 0.486008815107961 no 1630 0.449705033420456 2095 5356789 An amine of the fatty acid oleic acid.
SGTC_1732 st034308 51.822 µM 0.126225888504124 0.486078659664262 no 1631 0.449776559598709 1955 830119
SGTC_1933 st074711 15.9 µM 0.125978200562143 0.486174383669185 no 1632 0.449874590255764 2185 17250958
SGTC_3174 9107204 49.47 µM 0.125770005081797 0.486254845631585 no 1633 0.449956992837474 2146 3938802
SGTC_2192 5915882 198.485 µM 0.124823570330329 0.486620624253005 no 1634 0.450331613451969 2170 2876149
SGTC_1323 1348-1351 11.2 µM 0.124612533798993 0.486702187312937 no 1635 0.450415152605081 2043 6989654
SGTC_1157 4092-0394 27.6 µM 0.12433031774294 0.48681126126463 no 1636 0.450526871721194 2161 3659885
SGTC_2165 5727197 32.143 µM 0.12431540967484 0.486817023125544 no 1637 0.450532773394543 2087 1361712
SGTC_2872 9044037 25.97 µM 0.122251379314108 0.487614782023493 no 1638 0.451349968383089 2109 6465195
SGTC_288 1315-0019 35.1 µM 0.120976948379651 0.488107381423334 no 1639 0.451854646800759 2117 6811474
SGTC_287 k060-0039 29.6 µM 0.120822290500651 0.488167161807395 no 1640 0.45191589708879 2205 5861974
SGTC_2307 7538926 6.34 µM 0.120713406974888 0.488209249049932 no 1641 0.451959019712419 2078 96582
SGTC_1488 4013-0813 75.9 µM 0.119933966083939 0.488510533675102 no 1642 0.452267728810482 2075 2910057
SGTC_2589 lobaric acid 100 µM 0.119703681450774 0.488599549024706 no 1643 0.452358941978121 2064 73157 A novel microtubule depolymerizer.
SGTC_3173 9105693 49.47 µM 0.119264506829255 0.488769311303691 no 1644 0.45253290109995 2153 17096658
SGTC_1572 epiandrosterone 68.9 µM 0.116876910979446 0.489692267636294 no 1645 0.453478797552148 2111 441302 A steroid.
SGTC_1285 0929-0069 65.5 µM 0.115778403118439 0.490116929023858 no 1646 0.453914083603038 2100 1206237
SGTC_495 decylubiquinone 155 µM 0.115035779092188 0.49040401914412 no 1647 0.454208381332815 2065 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3026 9090633 49.47 µM 0.11497651921251 0.490426928565171 no 1648 0.454231866775552 2138 25236842
SGTC_3289 9119912 71.43 µM 0.114191767513363 0.490730310582813 no 1649 0.454542888896919 2154 17014829
SGTC_2013 4024628 200 µM 0.113678715272345 0.490928657534948 no 1650 0.454746242939217 2140 5230760
SGTC_1554 st069299 38.7 µM 0.113388085296995 0.491041016623215 no 1651 0.454861442673595 2129 24207999
SGTC_521 r062-0005 13.8 µM 0.113120102367729 0.491144620873641 no 1652 0.454967668949861 2063 2832033
SGTC_3280 9140961 49.47 µM 0.112481827892732 0.491391385061316 no 1653 0.455220688769358 2036 4901226
SGTC_195 4234-0266 16.654 µM 0.112404130052099 0.491421424159009 no 1654 0.455251490387347 2080 2303354
SGTC_320 4092-0846 5.34 µM 0.111494991787797 0.491772913599391 no 1655 0.455611918407198 2187 1359356
SGTC_2908 7930301 100 µM 0.107809180568555 0.493197978068368 no 1656 0.45707353014943 2217 2223178
SGTC_1186 1319-0216 26 µM 0.10678917111085 0.493592365771366 no 1657 0.457478119274389 2233 4565136
SGTC_683 panaxydol 45 µM 0.103191725283727 0.494983369297741 no 1658 0.458905403559806 2192 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2239 6685329 187.64 µM 0.102961434387886 0.495072416800688 no 1659 0.458996789564778 2075 805680
SGTC_3276 9139060 49.47 µM 0.102677569342845 0.495182180371833 no 1660 0.459109438303479 2249 4870619
SGTC_813 k007-0158 173 µM 0.101475275162414 0.495647081651043 no 1661 0.459586591896406 2191 6523916
SGTC_1600 coumarin 106 71.1 µM 0.101022054194989 0.495822334011536 no 1662 0.45976647650926 2176 100336 A hepatotoxic, DNA x-linker.
SGTC_3017 9080681 49.47 µM 0.100831488975232 0.495896022382108 no 1663 0.459842114815836 2109 16451914
SGTC_1003 4049-0218 100 µM 0.0998500714326107 0.496275522228667 no 1664 0.460231677695661 2182 295161
SGTC_2376 9072922 81.32 µM 0.0989632845635108 0.496618432682468 no 1665 0.46058371081532 2174 17087968
SGTC_2651 TUB2.036 5 µM 0.0972925026179425 0.497264511751768 no 1666 0.461247054899719 2228 15992207 YFL037W TUB2
SGTC_1141 3253-0389 52.6 µM 0.0972195440588585 0.497292724464863 no 1667 0.461276023824487 2219 5402031
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0950694447780513 0.498124162675246 no 1668 0.462129833828436 2179 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1743 st037606 46.3785 µM 0.0940271431018536 0.498527221377122 no 1669 0.462543797586426 2181 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_695 3505-6186 243 µM 0.0935749929084223 0.498702068627831 no 1670 0.462723387599739 2188 1819379
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0935134465883546 0.498725868714762 no 1671 0.462747833836033 2196 15053
SGTC_457 grayanotoxin iii 135 µM 0.0929975428885704 0.498925369893066 no 1672 0.462952756627641 2163 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0923352192532423 0.499181492393065 no 1673 0.463215853481807 2179 390807
SGTC_662 k832-1615 104 µM 0.0921002522183923 0.499272354923832 no 1674 0.463309194032111 2173 5878478
SGTC_666 0272-0154 136 µM 0.0909753702982111 0.499707350929308 no 1675 0.463756080769398 2165 6870312
SGTC_2242 6630449 61.2675 µM 0.0905905405479672 0.49985616612518 no 1676 0.463908974287274 2172 691249 YDR170C SEC7
SGTC_1236 0330-0013 258 µM 0.090218592331285 0.5 no 1677 0.464056755015686 2150 4617066
SGTC_476 mead acid 10 µM 0.0897113696285261 0.499803854939737 no 1678 0.464258290359659 2234 5312531 An omega 9 fatty acid.
SGTC_2705 st078069 42.8 µM 0.088807931335532 0.499454491864341 no 1679 0.464617277152985 2166 1530061
SGTC_2019 4016004 108 µM 0.0881906850668846 0.499215800573815 no 1680 0.464862560355193 2168 45595336
SGTC_2521 angolensin 13.4 µM 0.0878895352918071 0.499099344999305 no 1681 0.464982237022262 2165 821428 A flavenoid.
SGTC_1624 st003710 6.25 µM 0.0874757126915847 0.498939318612658 no 1682 0.465146694940049 2230 24207033
SGTC_1690 st023502 41.2 µM 0.0871195941101731 0.498801606671293 no 1683 0.465288225376232 2261 24207482
SGTC_2181 6316240 54.2555 µM 0.0866630287803987 0.498625051933602 no 1684 0.46546968228497 2158 12779990
SGTC_1188 1403-0014 4.57 µM 0.0863900510380429 0.498519491014204 no 1685 0.465578177742356 2154 9614867
SGTC_3325 9138760 55.175 µM 0.0860061882285725 0.498371050843197 no 1686 0.465730748980834 2158 43844959
SGTC_721 1187-1332 279 µM 0.0854627284810161 0.498160894751072 no 1687 0.465946762695219 2235 25730
SGTC_561 1550-0330 72.9 µM 0.0836215242074139 0.497448904493181 no 1688 0.46667867651466 2184 6812934
SGTC_1381 2324-0066 62.1 µM 0.0828396508898015 0.497146557866227 no 1689 0.466989520305467 2187 10885928
SGTC_1091 telmisartan 47.6 µM 0.0821414803229266 0.496876580067725 no 1690 0.467267104013419 2232 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_147 4466-0538 29.23 µM 0.0818442390928495 0.496761639337435 no 1691 0.467385288172756 2154 6742687 YHR072W ERG7
SGTC_1447 4239-0816 81.9 µM 0.081820001334128 0.496752266807917 no 1692 0.467394925317861 2100 1341554
SGTC_2627 acetyl isogambogic acid 100 µM 0.0794055933010158 0.495818646153095 no 1693 0.468355009940455 2175 6857789 A caspase activator and apoptosis inducer.
SGTC_2261 9010538 184.68 µM 0.0792033669133777 0.495740448768307 no 1694 0.468435433299193 2107 6457250
SGTC_271 rotenone 740 µM 0.0786183104024811 0.495514218645268 no 1695 0.468668111511226 2212 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2857 9024691 58.44 µM 0.0775686358400854 0.49510833330398 no 1696 0.469085596079099 2202 16478292
SGTC_1672 st016598 6.51 µM 0.0770764742250403 0.494918027290339 no 1697 0.469281354081826 2124 4665860 YNL267W PIK1
SGTC_3311 9131146 2.8755 µM 0.077036881708545 0.494902717950275 no 1698 0.469297102386566 2160 4900406 YPR165W RHO1
SGTC_1320 1313-0481 95.3 µM 0.0762496993144987 0.494598337699626 no 1699 0.469610221704182 2243 6813365 YLR208W SEC13
SGTC_1167 k781-0610 148 µM 0.0759686848588909 0.49448967843753 no 1700 0.469722006020826 2196 4525169
SGTC_2766 oltipraz 83.91 µM 0.0751102772998518 0.494157762377722 no 1701 0.470063485411205 2260 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1277 0873-0036 22 µM 0.0749486577565217 0.494095270221128 no 1702 0.470127781051761 2244 5965735
SGTC_2370 9071495 200 µM 0.0746398404851409 0.493975862681998 no 1703 0.470250637197025 2129 21791103
SGTC_1172 0370-0043 85 µM 0.0732145562676677 0.493424768280261 no 1704 0.470817691624397 2211 376585
SGTC_3211 9128781 49.47 µM 0.0731100479043238 0.493384359997013 no 1705 0.470859272993353 2049 17194361
SGTC_1220 1838-0075 193 µM 0.0728420759083355 0.493280748616557 no 1706 0.470965894068311 2205 5529645
SGTC_2428 5615643 7.78 µM 0.072094816422613 0.492991823130072 no 1707 0.471263225694109 2231 2253075
SGTC_1685 st024049 53.0905 µM 0.0720684041797084 0.492981610987338 no 1708 0.471273735316299 2207 1941139
SGTC_226 1,3-diallylurea 8.28947 mM 0.0717970533570766 0.492876695010518 no 1709 0.471381708925406 2223 74537 YKL182W FAS1
SGTC_2472 5377652 49.4 µM 0.0707136153136021 0.492457795936532 no 1710 0.471812842256132 2129 1610903
SGTC_1432 4049-0298 68.4 µM 0.0703668113467577 0.492323709837684 no 1711 0.471950853227439 2301 741646
SGTC_1888 azatryptophan 97.5 µM 0.0702814628810814 0.492290711377521 no 1712 0.471984818248292 2166 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1510 1123-0200 71.5 µM 0.0702266674507775 0.492269525730686 no 1713 0.472006624581718 2268 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_735 3076-0345 636 µM 0.0701192343155468 0.492227988745251 no 1714 0.472049378805866 2271 2888990
SGTC_2352 9027995 87.8 µM 0.069638453421749 0.492042104964289 no 1715 0.472240714907281 2222 2997347
SGTC_800 3448-7362 155 µM 0.0692415369299231 0.491888646884038 no 1716 0.4723986803693 2287 15991913
SGTC_977 1348-1378 135 µM 0.0659644484840626 0.490621688541692 no 1717 0.473703064890553 2290 X977
SGTC_3114 9122766 49.47 µM 0.0655460090745327 0.49045992182005 no 1718 0.473869637562746 2167 17176985
SGTC_1995 st072814 61.1 µM 0.065257565737107 0.490348411884867 no 1719 0.473984463963485 2126 5769371
SGTC_642 0335-0876 158 µM 0.0646503253217513 0.490113659972321 no 1720 0.474226207338105 2242 6812350
SGTC_1746 st038117 42 µM 0.0642153156468802 0.489945492513464 no 1721 0.474399391220961 2218 2898218
SGTC_2104 5389443 200 µM 0.0628433575638908 0.489415128331329 no 1722 0.474945619868483 2265 2244536
SGTC_934 2950-0684 338 µM 0.0609378095668406 0.488678523079049 no 1723 0.475704368851929 2300 1121253
SGTC_1041 0206-0046 107 µM 0.059973637310949 0.488305828917766 no 1724 0.476088315631566 2186 50494
SGTC_1886 st057356 49.9 µM 0.0586177479452026 0.487781736550743 no 1725 0.476628287086739 2257 24207747
SGTC_1994 st072947 40.9 µM 0.0585701829998768 0.487763351634401 no 1726 0.476647230208303 2213 5286565 YDL195W SEC31
SGTC_2043 5101342 149 µM 0.0584314700110117 0.487709736107075 no 1727 0.476702474071605 2250 678451
SGTC_512 prima-1 270 µM 0.0577195711121472 0.487434575522424 no 1728 0.476986002095516 2294 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2311 7694451 200 µM 0.0567266320942313 0.487050798346912 no 1729 0.477381479413116 2260 2163142
SGTC_3215 9129942 49.47 µM 0.0554983779710914 0.486576087033017 no 1730 0.477870711075985 2313 17682944
SGTC_2330 7979373 200 µM 0.0550382672169611 0.486398262423456 no 1731 0.478053988575415 2267 1863007
SGTC_2334 9017922 200 µM 0.0549507345630818 0.48636443291725 no 1732 0.4780888562852 2293 3163164
SGTC_2982 9019404 25.97 µM 0.0546650800994181 0.48625403423562 no 1733 0.478202644894361 2257 22333232
SGTC_227 fluconazole 33.516 µM 0.0545655854106288 0.486215582142862 no 1734 0.478242278378215 2255 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0541389316733222 0.486050693099427 no 1735 0.478412237362635 2309 1273210
SGTC_2844 9010103 25.97 µM 0.0533461617928553 0.485744317355224 no 1736 0.478728050373596 2225 2480525
SGTC_3291 9121177 71.43 µM 0.053001153012278 0.485610987053881 no 1737 0.478865494517798 2255 17015612
SGTC_767 0929-0023 86 µM 0.0515036043616091 0.48503227101746 no 1738 0.479462114900015 2314 1204563
SGTC_2835 9006588 71.43 µM 0.051368319991136 0.484979992958358 no 1739 0.47951601420848 2189 2345538
SGTC_1295 1013-0063 9.78 µM 0.0501745219941536 0.484518683833177 no 1740 0.479991657238928 2311 6826038
SGTC_554 4483-2211 187 µM 0.0484830344875949 0.483865092442025 no 1741 0.48066564252901 2258 747107
SGTC_1912 st060209 90.8 µM 0.0477049413548818 0.483564451422606 no 1742 0.480975697978455 2274 688787
SGTC_68 0986-0284 82.829 µM 0.0465356704247936 0.483112684049877 no 1743 0.481441651991698 2071 423278 YIL048W NEO1
SGTC_222 nsc-310342 10.666 µM 0.0456831212240232 0.482783301046434 no 1744 0.481781408537506 2324 432556
SGTC_1458 k015-0034 6.33 µM 0.045460260621716 0.48269720061891 no 1745 0.481870224780464 2246 3598957
SGTC_1956 st077085 54 µM 0.0451803909072775 0.482589076316187 no 1746 0.481981762038389 2288 24208685
SGTC_616 4092-0450 108 µM 0.0445678085171089 0.482352416947232 no 1747 0.482225901116877 2278 787165
SGTC_2131 toluylene red 5.2905 µM 0.0433682505824768 0.481889009006722 no 1748 0.482703993121969 2284 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_137 0438-0332 85.389 µM 0.0423824078968289 0.481508180891049 no 1749 0.483096926106024 2313 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1694 st024011 44.9 µM 0.0420301106297202 0.481372093572477 no 1750 0.48323734725381 2333 2787533
SGTC_1968 st069590 43.6 µM 0.0418932686476535 0.481319234086357 no 1751 0.483291891264909 2309 6384066
SGTC_303 1348-1668 34.2 µM 0.0411307744649348 0.481024702952074 no 1752 0.483595820440087 2293 5380509
SGTC_2205 7238770 200 µM 0.0409911812270303 0.480970782930202 no 1753 0.483651463158004 2331 279867
SGTC_276 colchicine 750 µM 0.040341105568216 0.480719685871884 no 1754 0.483910591465793 2251 2833 A microtubule depolymerizer.
SGTC_1771 st048882 4.1505 µM 0.0389066596904821 0.48016564658364 no 1755 0.484482403462836 2310 4580403
SGTC_1293 1000-1278 195 µM 0.0381157169616619 0.4798601697831 no 1756 0.48479771004638 2309 678847
SGTC_1497 4476-2978 41.3 µM 0.0378576384221899 0.479760497599216 no 1757 0.484900594230065 2300 1528379
SGTC_1452 4194-0072 190 µM 0.0375483633270388 0.479641054526329 no 1758 0.485023889477054 2343 1343545
SGTC_1307 1187-1599 12.2 µM 0.0365710655811993 0.479263630944817 no 1759 0.485413507206163 2293 1538471
SGTC_3088 9117578 49.47 µM 0.0356182892499505 0.478895695208265 no 1760 0.485793362430913 2340 678341
SGTC_999 SEC7.066 22.7 µM 0.0347280166278331 0.478551912913659 no 1761 0.486148310179397 2320 740511 YDR170C SEC7
SGTC_1530 rhein 70.4 µM 0.0340046904663569 0.478272609392612 no 1762 0.486436705207219 2346 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2802 7925815 54.55 µM 0.0331777740285114 0.477953318837672 no 1763 0.486766411059521 2318 1262923
SGTC_617 3770-0098 35 µM 0.0330022812365018 0.477885559038777 no 1764 0.486836384235019 2307 5962639
SGTC_1702 st027038 51 µM 0.0327193179720288 0.477776304993357 no 1765 0.486949209312121 2282 5521182
SGTC_2810 7959871 45.46 µM 0.0323135219345446 0.477619627294047 no 1766 0.487111012946057 2317 2974535
SGTC_183 3914-0051 30.55 µM 0.0309827966312515 0.477105859148618 no 1767 0.487641629693002 2335 1596232
SGTC_82 0054-0107 293.755 µM 0.0307368378689106 0.477010903212736 no 1768 0.487739706330588 2353 3104697
SGTC_164 4100-3994 89.624 µM 0.0306097375300344 0.47696183480069 no 1769 0.487790388181952 2356 4615967
SGTC_610 4215-0184 155 µM 0.0305138896919258 0.476924831973652 no 1770 0.487828608083714 2313 5605015
SGTC_440 fluspirilene 35.1 µM 0.0302070039137981 0.476806357596284 no 1771 0.487950981383178 2320 3396 An atypical antipsychotic.
SGTC_1810 st050138 53 µM 0.0301122859281527 0.476769791784935 no 1772 0.487988751210649 2358 3444541
SGTC_761 k216-0224 480 µM 0.0299269218217771 0.476698232669043 no 1773 0.488062667476535 2368 1340404
SGTC_1276 0871-0068 94.2 µM 0.0298227753548257 0.47665802764684 no 1774 0.488104197368551 2342 3414906
SGTC_3267 9137951 49.47 µM 0.0296954616299888 0.476608879388015 no 1775 0.4881549657109 2333 16643986
SGTC_2703 st077852 53.4 µM 0.0287081338250467 0.47622774296778 no 1776 0.488548684594226 2323 6281836
SGTC_1235 benzylparaben 21.5 µM 0.0285558823986586 0.476168971543447 no 1777 0.48860939923362 2317 7180
SGTC_310 1273-0058 1.06 µM 0.0285160610215504 0.476153599956507 no 1778 0.488625279197754 2340 2734232
SGTC_3113 9123498 49.47 µM 0.0269090756844212 0.475533311873069 no 1779 0.489266127395174 2364 8897275
SGTC_2682 pyrogallin 40.03 µM 0.0268804184221749 0.475522250850724 no 1780 0.489277555854717 2369 822798 An ATP competetive kinase inhibitor.
SGTC_342 k048-0088 23.3 µM 0.0262761615613483 0.475289026464925 no 1781 0.489518534331765 2368 6820570
SGTC_788 1182-0090 188 µM 0.0253387159485474 0.474927218352198 no 1782 0.489892396487306 2349 5715185
SGTC_107 0358-0022 2.6945 µM 0.0252764178673538 0.474903175072113 no 1783 0.489917241868207 2326 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_972 1319-0219 195 µM 0.024778618365215 0.474711057953138 no 1784 0.490115772947369 2325 23903702
SGTC_2968 9090663 33.37 µM 0.0247368938815827 0.474694955375892 no 1785 0.490132413507348 2268 25236811
SGTC_1716 st033144 30.6155 µM 0.0240124402767379 0.474415376260439 no 1786 0.490421342831464 2363 674617
SGTC_1088 bifonazole 369 nM 0.0219249548070239 0.473609850625434 no 1787 0.491253909250149 2358 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0211668393540355 0.473317333120331 no 1788 0.491556283357473 2368 688801
SGTC_2269 7935389 174.42 µM 0.0200644716423733 0.472892012204108 no 1789 0.491995970979244 2364 97605
SGTC_1387 3342-1166 1.8 µM 0.0195522158976782 0.472694381668404 no 1790 0.492200291363371 2331 3418228
SGTC_1754 st042065 16.137 µM 0.0190050933473067 0.472483306789436 no 1791 0.492418521120438 2353 1126236 YIL048W NEO1
SGTC_1256 0570-0116 285 µM 0.0188603335036832 0.472427461055207 no 1792 0.492476261593118 2356 410638
SGTC_2328 6201408 200 µM 0.0176643349011704 0.47196608722609 no 1793 0.492953316415943 2358 2890418
SGTC_1613 st002381 52.1 µM 0.0172403354138698 0.471802532266093 no 1794 0.493122441978598 2382 551167
SGTC_729 4092-0585 94.1 µM 0.0160324855610741 0.471336638441593 no 1795 0.493604237646027 2369 2169061
SGTC_3058 9093861 49.47 µM 0.0154750914755774 0.471121652669823 no 1796 0.493826578118553 2368 17217477
SGTC_2531 methyl deoxycholate 70.07 µM 0.0148079562155511 0.470864351018069 no 1797 0.494092696067976 2368 16667744 Haematoxylin.
SGTC_853 0419-0306 21 µM 0.0143380714008759 0.470683132485057 no 1798 0.494280133081432 2368 762713
SGTC_1840 st055363 71 µM 0.0142238819888229 0.470639094442307 no 1799 0.494325683420701 2346 676033
SGTC_1977 st070720 65.3 µM 0.0134634403625605 0.470345833345718 no 1800 0.494629026661089 2314 682188
SGTC_2315 7733312 200 µM 0.0132749447722268 0.470273143299788 no 1801 0.494704218801586 2373 726316
SGTC_2928 9011484 9.79 µM 0.0131516382073443 0.470225592803487 no 1802 0.494753406709665 2372 2994751
SGTC_2492 derrusnin 100 µM 0.0121022148430899 0.469820922746626 no 1803 0.49517203266646 2370 1715307 Part of coumarin class of compounds.
SGTC_2052 5265182 7.135 µM 0.0116551936157391 0.469648555518033 no 1804 0.495350355751343 2379 1239884
SGTC_2980 9014342 25.29 µM 0.0115268324256362 0.46959906168638 no 1805 0.495401561017333 2339 2996599
SGTC_1834 st055981 52.8 µM 0.0111261914191051 0.469444584540458 no 1806 0.495561383400906 2388 471719 YDL150W RPC53
SGTC_2086 5274770 176.623 µM 0.0109681037475927 0.469383631154688 no 1807 0.495624447408751 2375 689278
SGTC_88 0180-0332 8.668 µM 0.00954143591408148 0.468833587777343 no 1808 0.496193575553732 2390 3101745
SGTC_482 fipronil 114 µM 0.00826576347895679 0.468341810126771 no 1809 0.496702475017871 2389 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2045 5106652 78.05 µM 0.00698555758430798 0.467848333369704 no 1810 0.497213188392605 2392 673349
SGTC_2885 9057732 51.95 µM 0.00668342550156459 0.4677318786866 no 1811 0.49733371883918 2386 6471414
SGTC_1755 st041960 45.185 µM 0.0065575539642891 0.467683363203519 no 1812 0.497383933216783 2382 2257073
SGTC_480 am 92016 50 µM 0.00592115625578174 0.467438079670398 no 1813 0.497637814223788 2387 2129 K+ channel blocker.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.00482874735592485 0.467017066939795 no 1814 0.498073616004533 2374 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1904 st060225 78 µM 0.00479531191441973 0.467004181550995 no 1815 0.49808695466138 2396 66595
SGTC_198 3454-2873 16.191 µM 0.00378708949514731 0.466615647942477 no 1816 0.498489173492113 2395 710957
SGTC_795 0685-0265 78 µM 0.00300733288735861 0.46631517885186 no 1817 0.498800249568425 2402 302754
SGTC_2899 9053889 58.44 µM 0.00280774544157174 0.466238273498551 no 1818 0.498879873102494 2399 6470052
SGTC_203 k066-0004 30.888 µM 0.000629754705065722 0.465399129181423 no 1819 0.499748764238474 2399 6795412
SGTC_3190 9110366 49.47 µM 0.000408827114541609 0.465314017914514 no 1820 0.499836901583178 2405 17123768
SGTC_2114 5491910 81.25 µM 0 0.465156523468463 no 1821 0.5 2405 2849228
SGTC_1628 st004252 77.7 µM -0.000705074383581641 0.464884917091902 no 1822 0.499718716040867 2409 692968
SGTC_59 0330-0160 1.33 µM -0.000756543433716531 0.46486509099714 no 1823 0.499698182866122 2402 4293482
SGTC_866 0495-0101 262 µM -0.000992075818972786 0.464774364044545 no 1824 0.49960421907537 2409 635694
SGTC_1321 1326-2144 215 µM -0.00114458681708105 0.464715617863732 no 1825 0.499543376024778 2396 3513030
SGTC_563 tetrahydrosecaminediol 614 µM -0.00140368304887138 0.464615817552539 no 1826 0.499440011667416 2408 334274 A psychoactive constituent of the cannabis plant.
SGTC_131 0141-0277 33.849 µM -0.00168782002728132 0.464506374448886 no 1827 0.499326657549105 2409 1547771
SGTC_3059 1327-0034 3 µM -0.00175362511422035 0.464481028208278 no 1828 0.49930040515653 2414 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2424 5537928 59.2 µM -0.00261712432668812 0.464148446359525 no 1829 0.498955919644894 2408 5382802
SGTC_1133 3473-0247 50 µM -0.00274651496374174 0.464098612939734 no 1830 0.498904300434748 2420 711311
SGTC_3202 9113761 49.47 µM -0.00326943930856249 0.463897219967704 no 1831 0.498695684750297 2415 4798415
SGTC_448 monastrol 171 µM -0.00330414178920535 0.46388385538654 no 1832 0.498681840538314 2379 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_161 4065-0411 162.148 µM -0.00374086838572944 0.46371566720887 no 1833 0.498507612916284 2416 1906281 YLR208W SEC13
SGTC_3242 9133940 49.47 µM -0.00551041341807916 0.463034262785691 no 1834 0.497801674230277 2426 17248444
SGTC_453 enantio-paf c16 10 µM -0.00572522717707081 0.462951551099268 no 1835 0.497715977291872 2416 13871343 A lipid and platelet activating factor
SGTC_2483 5729050 27.16 µM -0.00596780879033714 0.462858149630341 no 1836 0.497619202884104 2420 2865180
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.00601598359063615 0.462839601076829 no 1837 0.497599984264421 2418 6708760
SGTC_2176 5809774 33.9695 µM -0.00661006037827266 0.462610872686508 no 1838 0.497362986642241 2422 2870539
SGTC_3316 9136639 10.545 µM -0.00853058622709341 0.461871526661132 no 1839 0.496596829752747 2451 4903665
SGTC_1031 k035-0009 16 µM -0.00857100174333297 0.461855969281196 no 1840 0.496580706883967 2416 5180959
SGTC_1273 0849-0096 14.1 µM -0.00874118270800508 0.461790461172352 no 1841 0.496512817045392 2430 5286025
SGTC_1656 st012921 11 µM -0.00931464360886936 0.46156972532985 no 1842 0.496284048571888 2425 6732821
SGTC_1981 st071826 47 µM -0.010084563885308 0.461273387221485 no 1843 0.495976909277191 2455 11838600
SGTC_1134 3477-0009 42.5 µM -0.0101358510868589 0.461253647819833 no 1844 0.49595644968973 2433 3973534
SGTC_317 4495-0002 170 µM -0.0106680759046437 0.461048810947158 no 1845 0.495744134196411 2433 15991618
SGTC_3303 9125618 40.5795 µM -0.0120068014769119 0.460533622684105 no 1846 0.495210094326837 2446 22695467
SGTC_969 1313-0238 134 µM -0.0122168343198684 0.460452800714796 no 1847 0.495126309491344 2425 5212874
SGTC_1087 pterostilbene 9.05 µM -0.0128584124409687 0.460205927518878 no 1848 0.494870376973108 2427 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2191 5911152 200 µM -0.0129449206527954 0.460172641148277 no 1849 0.494835868061995 2426 2875902
SGTC_377 3970-0964 33.1 µM -0.013181907977482 0.46008145530576 no 1850 0.494741331865256 2434 16481235
SGTC_1215 3852-0577 11.2 µM -0.0146877577361531 0.459502097286843 no 1851 0.494140643108912 2457 2884876
SGTC_2485 5633444 17.78 µM -0.0147245458626867 0.459487944558013 no 1852 0.494125968356768 2451 5724239
SGTC_3251 9135047 49.47 µM -0.0149086753935226 0.459417109014887 no 1853 0.494052519364594 2445 17682963
SGTC_551 k048-0028 34.9 µM -0.0149914095578433 0.459385281191168 no 1854 0.494019516896716 2438 6836383
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0153616060974507 0.459242869815067 no 1855 0.493871846852985 2441 641818
SGTC_664 1222-0054 14.9 µM -0.0181291532948592 0.458178385510071 no 1856 0.492767910402205 2446 6813991
SGTC_2425 5628681 7.85 µM -0.0184336902200873 0.458061269360261 no 1857 0.492646438047614 2448 5714958
SGTC_2715 st079500 56.4 µM -0.0190994103898063 0.457805265207304 no 1858 0.492380900892908 2433 28246688
SGTC_518 1021-0119 62.6 µM -0.0192349836059222 0.457753132371329 no 1859 0.492326824939114 2460 1097762
SGTC_1063 disulfiram 1.84 µM -0.019528213960345 0.457640377114918 no 1860 0.492209864923122 2448 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_875 0709-0210 25.7 µM -0.020347218258534 0.457325465188749 no 1861 0.491883194424132 2446 6251364
SGTC_371 0195-0006 7.36 µM -0.0204250905833834 0.457295524217742 no 1862 0.491852134316173 2421 3928593
SGTC_986 1493-0483 84 µM -0.0206213528018223 0.457220064834188 no 1863 0.491773853507095 2436 40079
SGTC_2356 9061756 188.97 µM -0.0214784012721395 0.456890562825668 no 1864 0.491432016388338 2432 20104043
SGTC_406 estrone 100 µM -0.0240689552624745 0.455894776046359 no 1865 0.49039880312859 2452 5870 A steroid.
SGTC_1246 0422-0085 105 µM -0.0241098492931492 0.455879058935319 no 1866 0.490382493503658 2447 264295
SGTC_2113 5491891 107.031 µM -0.0245833889071698 0.455697064921261 no 1867 0.490193634514065 2459 789979
SGTC_690 glyoxal 20.3 µM -0.0251099895082078 0.4554946890606 no 1868 0.489983616110126 2462 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1871 st057448 67.3 µM -0.0267861989191152 0.454850588572429 no 1869 0.489315130468319 2472 691747
SGTC_888 0916-0002 6.97 µM -0.027677638605797 0.454508092055417 no 1870 0.488959629338883 2566 2802138 YIL048W NEO1
SGTC_359 0081-0058 15.9 µM -0.0278634684395101 0.454436699361248 no 1871 0.488885522542587 2482 3494159
SGTC_2806 7952793 58.44 µM -0.0280594428294117 0.454361410894042 no 1872 0.48880737062994 2497 2972490
SGTC_2605 digitonin 300 nM -0.0283295266149337 0.454257654135114 no 1873 0.488699665606402 2458 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_791 1348-1292 225 µM -0.0288024636971217 0.454075975745849 no 1874 0.488511067975154 2538 5437054
SGTC_1814 st052110 31.539 µM -0.0302757940547498 0.453510058868535 no 1875 0.487923550633641 2465 674163
SGTC_817 1391-0715 46 µM -0.0309067015214593 0.453267751531498 no 1876 0.487671972718245 2474 1353946
SGTC_2407 paclitaxel 400 µM -0.031277974942866 0.45312516778946 no 1877 0.487523927631077 2674 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2957 9076800 11.52 µM -0.0319756324512829 0.452857255954082 no 1878 0.487245741722548 2494 16459615
SGTC_1597 7-benzyloxygramine 47.5 µM -0.034227455975709 0.451992666101166 no 1879 0.486347886330582 2471 260807
SGTC_1081 sertraline 6 µM -0.0345670534306077 0.451862296977183 no 1880 0.486212486672338 2463 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2140 5586273 200 µM -0.0351099047768491 0.451653910870604 no 1881 0.48599605170655 2463 854421
SGTC_1122 capsaicin 818.572 nM -0.0391827221580156 0.450090894058752 no 1882 0.484372354389073 2554 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3349 9149703 23.001 µM -0.0392470137541121 0.450066227144916 no 1883 0.484346725466851 2462 4910494
SGTC_769 0302-0231 76 µM -0.0397131933692853 0.449887372649051 no 1884 0.484160891593867 2503 571869 YER009W NTF2
SGTC_1619 st003326 88.7 µM -0.0404145762437647 0.449618299247151 no 1885 0.483881304790745 2476 2849032
SGTC_1353 1498-1206 8.11 µM -0.0413810450972571 0.449247568171375 no 1886 0.483496061836776 2463 6756808
SGTC_2522 biochanin a 4.94 µM -0.0414387441279437 0.449225436602059 no 1887 0.483473062981338 2503 5280373 A possible chelator.
SGTC_3010 9080089 71.4286 µM -0.0420641728532274 0.448985551575457 no 1888 0.483223770399677 2480 17027233
SGTC_1430 4049-0248 69.1 µM -0.0426229524341739 0.448771245793567 no 1889 0.483001049358719 2492 22774488
SGTC_3069 9117009 49.47 µM -0.0431359968469589 0.44857449373899 no 1890 0.482796562329386 2479 41904981
SGTC_1308 1187-1617 41.4 µM -0.0435710311152048 0.448407668409388 no 1891 0.482623171790429 2469 2882570
SGTC_2929 9013348 24.6 µM -0.0439687353509307 0.448255166243885 no 1892 0.482464662665595 2534 2995952
SGTC_2381 9035592 200 µM -0.044130702934506 0.448193060955423 no 1893 0.482400109607573 2513 4749657
SGTC_2938 9059746 27.26 µM -0.0451810456701693 0.447790345578362 no 1894 0.481981501092258 2535 6471769
SGTC_1850 st056238 17 µM -0.0454134681401535 0.447701238968077 no 1895 0.481888873020098 2481 5393177
SGTC_2499 avocadenofuran 51.48 µM -0.0467900691595819 0.447173529062122 no 1896 0.481340272014256 2498 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1621 st003705 32.4 µM -0.0479202276734197 0.446740360938904 no 1897 0.480889909278166 2474 24207032
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0480880452329673 0.446676045086249 no 1898 0.480823036853064 2530 75037 A free radical scavenger.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0485865567410186 0.446484999503316 no 1899 0.480624391739523 2510 6857784
SGTC_1417 3966-0327 90.4 µM -0.0494688132359211 0.446146921015412 no 1900 0.480272845095711 2494 651118
SGTC_3080 9117754 49.47 µM -0.0497428738774904 0.446041909618569 no 1901 0.480163645157737 2488 9550191
SGTC_539 4859-0462 2.54 µM -0.0498687614065963 0.445993674754634 no 1902 0.48011348555188 2493 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1389 3405-0187 19 µM -0.0505947890151543 0.445715506797974 no 1903 0.479824207636284 2529 799890
SGTC_2212 7123476 200 µM -0.0510401246611601 0.445544895497955 no 1904 0.479646773671531 2498 1085715
SGTC_1185 1319-0113 81.3 µM -0.052001828162799 0.445176494388393 no 1905 0.479263618361708 2553 4672763
SGTC_1748 st037455 53.6035 µM -0.0527377115099748 0.444894630477035 no 1906 0.478970445690085 2555 580690
SGTC_1662 st014054 52 µM -0.0556990906974364 0.4437606224641 no 1907 0.477790761949051 2493 2838777
SGTC_1964 st076914 61 µM -0.0557410570265833 0.44374455548364 no 1908 0.477774045775728 2489 24208661
SGTC_3334 9142812 21.919 µM -0.056974321858775 0.443272436404727 no 1909 0.47728282504706 2591 45283678
SGTC_290 2043-6722 48.1 µM -0.057186187945068 0.443191337806374 no 1910 0.477198440288979 2546 773758 YLR208W SEC13
SGTC_3187 9109394 49.47 µM -0.0584968363779832 0.442689697742887 no 1911 0.476676441193082 2546 17098090
SGTC_558 k064-0027 21.3 µM -0.0585370033760424 0.442674325596689 no 1912 0.476660444291275 2559 5088526
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0592472011712826 0.442402543000603 no 1913 0.47637760727371 2533 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1436 4092-1007 8.32 µM -0.059717734856392 0.442222491371589 no 1914 0.47619022328513 2519 2881121
SGTC_728 3030-5151 22.5 µM -0.0601370596823635 0.442062045076962 no 1915 0.476023237001751 2520 3125388
SGTC_510 ag-490 170 µM -0.0603186519418 0.441992565362628 no 1916 0.475950923445679 2510 5328779
SGTC_2194 5927483 104.545 µM -0.0614768007434257 0.441549483659123 no 1917 0.475489744888733 2500 760979
SGTC_1836 st055642 81 µM -0.0628645974362997 0.441018640205853 no 1918 0.474937163106595 2515 8571
SGTC_2310 7668677 200 µM -0.0631556917488489 0.440907307689603 no 1919 0.474821263583344 2570 2197143
SGTC_2450 5739737 12.93 µM -0.0649691660115043 0.44021382819117 no 1920 0.474099275163714 2565 2262825
SGTC_325 2810-4341 181 µM -0.0650557656160914 0.440180716741184 no 1921 0.474064799854057 2534 774970
SGTC_3004 9076122 71.4286 µM -0.0651157686982293 0.440157774744891 no 1922 0.474040912736053 2561 44782551
SGTC_1487 3970-0795 2.82 µM -0.065230450706314 0.440113926986287 no 1923 0.473995258296681 2575 3765103
SGTC_1007 4101-0031 70 µM -0.0652903020324075 0.440091043596845 no 1924 0.473971431863625 2520 1146276
SGTC_1343 1487-0095 224 µM -0.0654983154002551 0.440011513901579 no 1925 0.473888623786759 2512 4560101 YGL055W OLE1
SGTC_417 st075190 100 µM -0.0668455427557475 0.439496487568974 no 1926 0.473352333294127 2510 222757
SGTC_1627 st003713 25.6 µM -0.067923831096371 0.439084346618679 no 1927 0.472923134043987 2582 16195070 YER133W GLC7
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0715599900841321 0.437695031399405 no 1928 0.471476040846599 2700 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1033 k072-0102 21.3 µM -0.0715978346151014 0.437680575647693 no 1929 0.47146098169067 2519 5965931
SGTC_1080 nisoldipine 24.4 µM -0.0749953590646017 0.436383139646976 no 1930 0.470109202212847 2535 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_685 1278-0033 54.9 µM -0.0755974984176226 0.436153267528338 no 1931 0.469869663372192 2540 3590572
SGTC_605 1315-0399 119 µM -0.0768279446184455 0.435683600751639 no 1932 0.469380209921366 2626 24020461
SGTC_738 1315-0003 72.4 µM -0.0775663505592773 0.435401791429671 no 1933 0.469086505035652 2591 6251474
SGTC_1239 0337-0584 35.4 µM -0.0783276941601698 0.435111262401398 no 1934 0.468783694189046 2624 914301 YML130C ERO1
SGTC_974 1326-0144 138 µM -0.0785476806251852 0.43502732199252 no 1935 0.46869620184865 2560 5411856
SGTC_322 k048-0136 19.3 µM -0.0789118337359753 0.434888378239933 no 1936 0.46855137531781 2632 6823282
SGTC_937 3122-0005 46.7 µM -0.0793913736219726 0.434705420572291 no 1937 0.468360664918689 2545 759535
SGTC_3156 9099931 49.47 µM -0.0798190332335684 0.434542268450575 no 1938 0.468190593145331 2564 18111053
SGTC_1757 st041620 31.8375 µM -0.0802330624404798 0.434384326947085 no 1939 0.468025947444922 2601 5289815
SGTC_762 1165-0429 115 µM -0.0815115037219622 0.433896700651734 no 1940 0.467517588337574 2520 5967793
SGTC_1881 5652484 16 µM -0.0816023587174005 0.43386205032974 no 1941 0.467481462783687 2547 2255129
SGTC_2079 5212404 121 µM -0.0831281213382049 0.433280230384208 no 1942 0.466874832815646 2559 758462
SGTC_2783 7738165 71.43 µM -0.0836266102497755 0.433090172590333 no 1943 0.466676654559447 2615 17201110
SGTC_3213 9129884 49.47 µM -0.0840461261888548 0.432930236641424 no 1944 0.466509879040241 2619 17190742
SGTC_3350 9150499 3.57 µM -0.0853208045243942 0.432444346715342 no 1945 0.466003176110312 2567 4910996 YPR165W RHO1
SGTC_2337 9009472 200 µM -0.0857416480076892 0.432283949335582 no 1946 0.465835896846354 2578 5742383
SGTC_2572 astragaloside iv 100 µM -0.0866441439543634 0.431940015921568 no 1947 0.465477188007917 2721 45006101 An anti-inflammatory agent.
SGTC_458 nppb 133 µM -0.0912006108121667 0.430204378549884 no 1948 0.463666594809897 2611 4549 A chloride channel blocker.
SGTC_847 0342-0274 5.54 µM -0.0923889479254064 0.429751940521165 no 1949 0.463194510074927 2661 18097
SGTC_3306 9127676 59.7925 µM -0.0929377923008289 0.429543008978499 no 1950 0.46297649087403 2625 41905287
SGTC_376 3970-0862 59.1 µM -0.0933526882899882 0.429385081382677 no 1951 0.462811687794779 2638 3135186
SGTC_843 0310-0051 143 µM -0.0935656888288925 0.429304008431701 no 1952 0.462727083176837 2581 2065037
SGTC_2948 9070189 9.45 µM -0.0947376001243109 0.42885800520663 no 1953 0.462261625848172 2632 6473636 YDL196W YDL196W
SGTC_2458 5808907 16.39 µM -0.0954338198843427 0.428593082509692 no 1954 0.461985127137388 2575 2731747
SGTC_3222 9128301 49.47 µM -0.095501638517885 0.428567278158186 no 1955 0.461958194430671 2606 4911358
SGTC_1791 st048313 56.1 µM -0.0966504868853644 0.428130198661233 no 1956 0.461501980699955 2593 1204976
SGTC_2415 st077333 57.7 µM -0.0973631522357022 0.427859109316047 no 1957 0.461219002959142 2564 2766255
SGTC_2736 butenafine 14.65 µM -0.0978292292275716 0.427681837629928 no 1958 0.461033948567879 2612 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_335 4077-0256 27.6 µM -0.0982653253752775 0.427515982331719 no 1959 0.460860805615789 2693 3121989
SGTC_1156 4092-0367 4.88 µM -0.100485925558067 0.426671646958345 no 1960 0.459979278028821 2602 1357585
SGTC_196 k015-0023 18.111 µM -0.102301084071096 0.425981721370751 no 1961 0.45925884742983 2587 5211998
SGTC_820 1582-0060 59.9 µM -0.103422935870746 0.4255554286105 no 1962 0.458813654779822 2622 3848840
SGTC_2801 7907800 81.82 µM -0.104682081762444 0.425077069081789 no 1963 0.458314040257606 2663 6620925
SGTC_2241 6772625 37.8075 µM -0.104836102971367 0.425018562757428 no 1964 0.458252930928199 2561 2285411
SGTC_949 1165-0505 146 µM -0.105247551737659 0.42486227839065 no 1965 0.458089689693424 2594 6244267
SGTC_3065 9113888 49.47 µM -0.105492292993772 0.42476932166967 no 1966 0.457992592583684 2719 16648368
SGTC_2856 9022925 19.48 µM -0.106818837066824 0.424265551511599 no 1967 0.457466351579639 2714 4944862
SGTC_1464 k208-0027 110 µM -0.106877770200474 0.424243173849653 no 1968 0.457442974485502 2632 X1464
SGTC_1733 st037357 54.9 µM -0.108470548067362 0.423638468521944 no 1969 0.456811220940932 2592 1272339 YGL099W LSG1
SGTC_1166 k206-0078 225 µM -0.108792577645732 0.423516230338562 no 1970 0.456683505527776 2583 5404595
SGTC_2484 5809818 12.04 µM -0.109326628924049 0.423313527742861 no 1971 0.456471713176898 2649 2870548
SGTC_1991 st073000 8.92 µM -0.109918247719109 0.423088998723292 no 1972 0.456237105323089 2789 4301969 YIL048W NEO1
SGTC_525 k781-2675 26.7 µM -0.109935148262807 0.423082585056858 no 1973 0.456230403595648 2594 3651118 YDL195W SEC31
SGTC_3225 9130819 49.47 µM -0.109953063968364 0.423075786164156 no 1974 0.45622329933037 2604 4547121
SGTC_1470 k295-0292 231 µM -0.110004072931629 0.423056428722778 no 1975 0.456203072394167 2703 5045612
SGTC_1779 st039427 55 µM -0.110040582975621 0.423042573604518 no 1976 0.456188594884164 2592 1124498
SGTC_828 2074-0507 139 µM -0.113736334357433 0.421640576186987 no 1977 0.454723404372784 2714 X828
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.113781871455569 0.421623307669603 no 1978 0.454705354868203 2614 688669
SGTC_2225 6654152 15.4 µM -0.114092880990761 0.421505371081875 no 1979 0.454582082760281 2600 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2361 9034121 116 µM -0.114291661225732 0.421429996171871 no 1980 0.454503296281317 2652 6496917
SGTC_1663 st014140 55.4 µM -0.114725005111722 0.421265687723478 no 1981 0.454331546787024 2610 4207120
SGTC_2271 7849410 118.62 µM -0.118352236346308 0.419890912173081 no 1982 0.452894284789668 2578 972430
SGTC_235 0330-0087 5 mM -0.119949034882875 0.419286010073978 no 1983 0.45226176031552 2623 46494818 YHR062C RPP1
SGTC_1855 st056195 39.6 µM -0.122768665179069 0.4182183392059 no 1984 0.451145144038733 2722 4028379
SGTC_2867 9039098 71.43 µM -0.12476833875904 0.417461514721288 no 1985 0.450353476746568 2610 6463460
SGTC_2405 ticlatone 3.52 µM -0.125384883562843 0.417228230054901 no 1986 0.450109427419178 2580 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2452 5863136 48.41 µM -0.125967564649397 0.41700778532386 no 1987 0.449878799836912 2610 2184096
SGTC_2083 5306046 65.942 µM -0.126367570574488 0.416856466870575 no 1988 0.449720485632725 2667 539837
SGTC_1715 st032160 10.2275 µM -0.127298828723716 0.416504228487071 no 1989 0.449351943654555 2693 5289825
SGTC_1383 3049-0032 20.7 µM -0.127449658378214 0.416447185092305 no 1990 0.449292257477647 2756 712864
SGTC_3209 9113616 49.47 µM -0.128471136660072 0.416060910953534 no 1991 0.448888069263787 2696 16649353
SGTC_3032 9089427 49.47 µM -0.129175207268289 0.415794712360958 no 1992 0.448609506781099 2727 17173707
SGTC_1711 st032263 62.8 µM -0.129928654656284 0.41550988793909 no 1993 0.448311436654118 2681 3958979
SGTC_2208 7283366 200 µM -0.130744070644541 0.415201687650316 no 1994 0.447988884108888 2654 898663
SGTC_1788 fluconazole 20 µM -0.13103386068748 0.415092169149235 no 1995 0.44787426068577 2721 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3272 9137413 49.47 µM -0.131840032961336 0.414787532340074 no 1996 0.447555410593026 2639 17614870
SGTC_3197 9113331 49.47 µM -0.132376725339604 0.414584755135391 no 1997 0.447343161570251 2788 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_635 k038-0028 24.7 µM -0.13275899589423 0.414440336637066 no 1998 0.447191991883669 2672 4035102
SGTC_889 0919-1524 82.7 µM -0.134012491247956 0.413966858212789 no 1999 0.446696348474448 2705 3905452
SGTC_2217 6934799 96.0675 µM -0.135554032948898 0.413384748538993 no 2000 0.446086923160481 2655 675606
SGTC_21 0849-0113 22.993 µM -0.136057975756765 0.4131944932627 no 2001 0.44588772450288 2642 1560156
SGTC_863 0466-0191 129 µM -0.136392232132078 0.413068311534826 no 2002 0.445755607077673 2643 765160 YPR165W RHO1
SGTC_3237 9133362 49.47 µM -0.136576608122176 0.412998713470285 no 2003 0.445682733613908 2674 43845137
SGTC_2384 9036245 200 µM -0.136636637042363 0.412976054403422 no 2004 0.445659007952287 2717 6462766
SGTC_2335 9018011 154.17 µM -0.137423600465002 0.412679026812744 no 2005 0.445347988771405 2762 6458208
SGTC_118 0083-0097 135.343 µM -0.137528520845646 0.412639429955339 no 2006 0.445306525275821 2681 5207356
SGTC_1288 0973-0013 65.5 µM -0.13863664403859 0.412221279611152 no 2007 0.4448686425773 2740 4315430
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.138915328389228 0.412116133716974 no 2008 0.444758529054609 2645 229346 A bile salt which induces apoptosis.
SGTC_1846 st056244 14.8 µM -0.140599003127345 0.411481028021672 no 2009 0.444093367901994 2718 5393182
SGTC_723 4182-0001 115 µM -0.141106826788627 0.411289515263224 no 2010 0.443892775309461 2686 744821 YLR208W SEC13
SGTC_1058 3448-5425 97.3 µM -0.141472299063792 0.411151699781481 no 2011 0.443748421035669 2634 7279705
SGTC_2601 securinine 100 µM -0.141731787040874 0.41105385644076 no 2012 0.443645932979645 2692 442872 A GABA receptor antagonist.
SGTC_2815 7968870 71.43 µM -0.142358593693638 0.41081753361867 no 2013 0.443398383332361 2680 2977326 YHR190W ERG9
SGTC_944 3370-0224 231 µM -0.142430117293088 0.410790569370362 no 2014 0.443370137360799 2691 4580514
SGTC_1567 st069303 68.4 µM -0.14328221116308 0.410469364215367 no 2015 0.443033652151987 2764 5581319
SGTC_2348 9022543 33.42 µM -0.143330558417117 0.41045114104107 no 2016 0.443014561428541 2771 3162678 YDL140C RPO21
SGTC_1737 st035557 69.7 µM -0.143963704820153 0.410212511690175 no 2017 0.442764565187717 2619 5716916
SGTC_252 miconazole 1.30953 nM -0.144216291037448 0.410117322623779 no 2018 0.442664838517538 2717 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2596 sinensetin 100 µM -0.144974622422011 0.409831571425316 no 2019 0.442365454229277 2715 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1369 1866-0067 208 µM -0.145556682830116 0.409612274377447 no 2020 0.442135682890677 2694 3531355
SGTC_1647 st011722 22.4 µM -0.145969265869427 0.409456846734611 no 2021 0.441972825399613 2792 2854783
SGTC_905 2-aminofluorene 215 µM -0.146578444306068 0.409227384002288 no 2022 0.441732384419251 2663 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1704 st028805 70.8 µM -0.148921834837421 0.408344976245573 no 2023 0.440807655813039 2716 2876101
SGTC_2713 st079149 53.4 µM -0.149290374751488 0.408206244063684 no 2024 0.440662254998556 2742 3103253
SGTC_1103 duloxetine 36.1 µM -0.149887464248693 0.407981501714348 no 2025 0.44042670103223 2832 60835 A selective serotonin reuptake inhibitor.
SGTC_1653 st012112 65 µM -0.149962774797022 0.407953157241935 no 2026 0.440396992243916 2816 720429
SGTC_2905 7799065 20.05 µM -0.150901277560615 0.407599975386068 no 2027 0.440026796340433 2769 1296806
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.152145698255088 0.407131784863005 no 2028 0.439536010866824 2690 689007
SGTC_2916 7875993 68.79 µM -0.153284311201284 0.406703518772497 no 2029 0.439087036155279 2686 1299250
SGTC_2190 6049624 200 µM -0.153667579353854 0.40655938532573 no 2030 0.438935924514071 2645 2265554
SGTC_2760 etidronate 98.04 µM -0.154751160248008 0.40615195784467 no 2031 0.438508747862154 2717 3305 A chelator and antioxidant.
SGTC_595 3909-8003 73.7 µM -0.155018763279393 0.40605135446994 no 2032 0.438403262579273 2773 699517
SGTC_2101 5377231 179.231 µM -0.156077239352496 0.4056534890959 no 2033 0.437986069423989 2796 2844213
SGTC_2188 6126565 140.678 µM -0.157887636205343 0.404973213994784 no 2034 0.43727267037015 2750 874518
SGTC_607 4491-0986 66.8 µM -0.158632747778081 0.404693313981663 no 2035 0.436979113240679 2810 698981 YDR232W HEM1
SGTC_756 0508-1999 28.3 µM -0.158849355373843 0.404611954814011 no 2036 0.436893781242763 2693 6753853
SGTC_1370 2001-0092 44.6 µM -0.159050976387408 0.404536228406213 no 2037 0.436814355808141 2807 790957
SGTC_1355 1499-0035 1.68 µM -0.161347733721341 0.403673847245872 no 2038 0.435909764825835 2703 1548538
SGTC_3265 9137266 49.47 µM -0.164468234683373 0.402502919437993 no 2039 0.434681275628134 2655 17224265
SGTC_2555 cholic acid 100 µM -0.16513332291784 0.40225346629818 no 2040 0.434419522574532 2868 6708657 Influences liver metabolism.
SGTC_1324 1418-0026 34.4 µM -0.165289936316974 0.402194731450999 no 2041 0.434357889764002 2792 1372513
SGTC_2322 7413319 38.22 µM -0.166033893870764 0.401915754642192 no 2042 0.434065138449938 2821 1840400
SGTC_2583 asiatic acid 100 µM -0.166065544859351 0.401903886938087 no 2043 0.43405268441583 2839 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2017 5132927 60.65 µM -0.166970699247574 0.401564532876245 no 2044 0.43369655192923 2715 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2921 7974240 10.71 µM -0.167197990897818 0.40147932995213 no 2045 0.433607132599843 2835 2979074 YDR527W RBA50
SGTC_2657 nystatin 74.44 µM -0.167844163964164 0.401237130045944 no 2046 0.433352938749401 2743 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2490 carminic acid 95.39 µM -0.1689916529808 0.400807119451715 no 2047 0.432901603464919 2657 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1520 flindersine 88 µM -0.169787363039263 0.400509005196818 no 2048 0.432588682731756 2982 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2541 muurolladie-3-one 83.07 µM -0.170680231964532 0.400174559189496 no 2049 0.432237603667804 2881 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3180 9109287 49.47 µM -0.17082973917387 0.400118564736342 no 2050 0.432178822152024 2838 18891271
SGTC_36 0335-0881 14.2 µM -0.170893064617466 0.400094848281069 no 2051 0.432153925038893 2699 23828853
SGTC_2546 rhodinyl acetate 100 µM -0.171079464097892 0.400025040645333 no 2052 0.432080641542726 2714 6708682
SGTC_994 3910-0338 138 µM -0.171520365617381 0.399859933307875 no 2053 0.431907309137711 2864 3479481
SGTC_1971 st069429 63.5 µM -0.171766715938898 0.399767688650954 no 2054 0.431810466699846 2822 1246522 YGL099W LSG1
SGTC_364 0083-0097 67.7 µM -0.172001778365862 0.399679675905201 no 2055 0.431718065451123 2844 5207356
SGTC_1037 k284-1091 78.7 µM -0.173381187911408 0.399163296298455 no 2056 0.431175905518394 2694 3334711
SGTC_697 0508-1955 564 µM -0.174276475482305 0.398828241264887 no 2057 0.430824093083568 2799 6243113
SGTC_1980 st071811 45.7 µM -0.174748039787138 0.398651791618558 no 2058 0.430638809104508 2860 4974850
SGTC_1602 st001878 87.6 µM -0.176094061200853 0.398148252203412 no 2059 0.430110023248746 2911 595405 YLR310C CDC25
SGTC_2116 5511452 16.8835 µM -0.177812971315706 0.397505463762532 no 2060 0.429434930026148 2836 870744
SGTC_604 1000-0114 314 µM -0.177995090342783 0.397437376409939 no 2061 0.429363415756047 2853 1572745
SGTC_916 4466-0038 42 nM -0.178088833565184 0.397402330615422 no 2062 0.429326605689171 2810 5722064 YGL116W CDC20
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.178321734863859 0.397315264321646 no 2063 0.429235155206214 2746 279621
SGTC_251 melphalan 456.522 µM -0.178697206307803 0.397174911314538 no 2064 0.42908773146022 2788 460612 A DNA alkylator.
SGTC_1557 sumaresinolic acid 42.3 µM -0.179223209194707 0.396978311335589 no 2065 0.428881220233255 2717 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1901 st060216 58.6 µM -0.179430095064291 0.396900992395088 no 2066 0.428800001191217 2726 688792
SGTC_1561 5-methoxyflavone 52.9 µM -0.179816139650018 0.396756727752822 no 2067 0.428648456268816 2717 94525
SGTC_864 0469-0573 172 µM -0.180782254245053 0.396395753246715 no 2068 0.428269246328277 2701 689425
SGTC_1842 st055362 61.2 µM -0.182217818187077 0.39585953997336 no 2069 0.427705895094809 2746 676032
SGTC_710 3448-4187 58 µM -0.183665911183189 0.395318846432161 no 2070 0.427137776429819 2745 3946412
SGTC_2655 perillic acid 100 µM -0.183769332183401 0.39528023846789 no 2071 0.427097207868196 2724 5702197 An apoptosis inducer.
SGTC_2711 st079103 59.1 µM -0.183879555546387 0.395239092253615 no 2072 0.427053971818421 2814 54693780
SGTC_1046 2001-0062 216 µM -0.184226053824248 0.395109752580954 no 2073 0.426918060637214 2700 739778
SGTC_3238 9133470 49.47 µM -0.185759902165895 0.39453734199124 no 2074 0.426316525299161 2873 3534688
SGTC_903 1134-0042 114 µM -0.187585996528727 0.393856166209852 no 2075 0.425600602259375 2746 701009
SGTC_2139 5578692 56.4705 µM -0.187806887851267 0.393773790563696 no 2076 0.425514018062484 2793 650991 YMR113W FOL3
SGTC_2275 7947463 200 µM -0.18819334908743 0.393629681379856 no 2077 0.425362543000053 2692 1225414
SGTC_2207 7258803 200 µM -0.188374212163733 0.393562243576627 no 2078 0.425291656760309 2821 3666799
SGTC_368 fentichlor 4.58 µM -0.188493601715842 0.393517728947558 no 2079 0.425244865357217 2817 7329 A pesticide.
SGTC_826 1683-5028 118 µM -0.188720885131094 0.39343298972673 no 2080 0.42515579087642 2819 722377
SGTC_1005 4092-0690 4.4 µM -0.188763322396046 0.393417168186532 no 2081 0.425139159741396 2793 1529343
SGTC_1652 st011932 78 µM -0.189539588309127 0.393127790361667 no 2082 0.424834965198935 2820 1551076
SGTC_965 1291-5240 308 µM -0.190386534867753 0.392812131431026 no 2083 0.424503124160828 2858 2834598
SGTC_3199 9111318 49.47 µM -0.190561500074414 0.392746930273319 no 2084 0.424434577929675 2858 8548020
SGTC_2098 5376439 882.5 nM -0.190666512915656 0.392707798458998 no 2085 0.424393438078905 2830 2844116
SGTC_1998 st075797 76.8 µM -0.191054292678989 0.392563306238285 no 2086 0.424241528544956 2691 24208315
SGTC_941 3237-0776 460 µM -0.191390904873117 0.392437891781761 no 2087 0.424109672609363 2912 760008
SGTC_3132 9126706 49.47 µM -0.194295872760884 0.391356028735901 no 2088 0.422972108559231 2959 850858
SGTC_2526 patulin 37.61 µM -0.194398089367401 0.391317976655374 no 2089 0.422932092924468 2896 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1837 st055472 66.5 µM -0.194430144711878 0.391306043656485 no 2090 0.422919544100342 2911 676091
SGTC_970 1315-0089 19.5 µM -0.194494139020098 0.391282221288874 no 2091 0.422894492246019 2759 6811083 YLR033W RSC58
SGTC_485 niflumic acid 177 µM -0.194591417454336 0.391246009433556 no 2092 0.422856411250866 2858 4488 A COX2 inhibitor.
SGTC_2128 5255449 168.493 µM -0.198097000535478 0.389941689025198 no 2093 0.421484585779303 2766 736008
SGTC_3111 9122088 49.47 µM -0.198511422945727 0.38978757666462 no 2094 0.421322474185618 2815 16876704
SGTC_2281 7943571 200 µM -0.198526209076659 0.389782078426872 no 2095 0.421316690470392 2901 1244024
SGTC_1061 3448-9325 110 µM -0.203024692439681 0.388110341828373 no 2096 0.419557866167135 2719 723482
SGTC_2418 pentamidine 31.67 µM -0.20305032013689 0.388100823909763 no 2097 0.419547850775821 2723 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2697 mebhydrolin 72.4 µM -0.204174092042241 0.387683530319222 no 2098 0.419108728226476 2895 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_959 1222-0044 107 µM -0.205014547789042 0.387371526111191 no 2099 0.41878037947141 2859 6083612
SGTC_1712 st032288 53.4 µM -0.205351403212251 0.38724649494934 no 2100 0.418648792861856 2824 2883011
SGTC_11 0438-0307 1.3 µM -0.208279112268596 0.386160306432585 no 2101 0.417505520006788 2884 4011476
SGTC_1824 st053723 68.6 µM -0.208720033457046 0.385996800444904 no 2102 0.417333400064687 2811 675225
SGTC_2354 9060492 162 µM -0.210024186161211 0.385513302533621 no 2103 0.416824398088566 2922 6471895
SGTC_1444 4112-3581 28 µM -0.211018352725888 0.385144847439176 no 2104 0.416436475196645 2775 2877249
SGTC_960 1222-0186 7.7 µM -0.211284195659228 0.385046339064726 no 2105 0.4163327572989 2902 3126296
SGTC_2117 5521686 200 µM -0.21134683748023 0.38502312815278 no 2106 0.416308318610542 2759 803312
SGTC_2318 6029776 164 µM -0.212364831205732 0.384645984873543 no 2107 0.415911210321517 2947 818325
SGTC_1230 0170-0365 3.77 µM -0.216000143990806 0.383300078127517 no 2108 0.414493817662969 2896 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1683 st010134 710 nM -0.216023058255292 0.383291598994856 no 2109 0.414484887000464 2776 3818134
SGTC_249 wiskostatin 11.211 µM -0.217143370116028 0.382877110072788 no 2110 0.414048307868957 2800 2775510 A n-wasp and actin depolymerizer.
SGTC_702 1488-0190 94 µM -0.220779158283657 0.381532880294163 no 2111 0.412632196220855 2879 949357
SGTC_1067 clotrimazole 1.36 µM -0.221825340516711 0.381146347804807 no 2112 0.412224925987529 2796 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_726 3448-4391 34.2 µM -0.222303732263199 0.380969636092233 no 2113 0.412038723433985 2971 1356692
SGTC_696 1560-0013 611 µM -0.22275390206893 0.380803371866976 no 2114 0.411863523679145 3010 1650269
SGTC_2978 9011784 42.97 µM -0.222817657388296 0.380779826466985 no 2115 0.411838712425248 2927 2994934
SGTC_1379 2144-0755 36.5 µM -0.223515608772573 0.380522095775511 no 2116 0.411567118175212 2941 5392327
SGTC_2739 tacrine 100.86 µM -0.224269518640086 0.380243761011342 no 2117 0.411273796367538 2904 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2772 vinpocetine 57.06 µM -0.226393206807402 0.379460053749148 no 2118 0.41044780548563 2985 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_885 0865-0106 16.8 µM -0.228016547136444 0.378861324084539 no 2119 0.409816688292413 2801 2793380
SGTC_3247 9135149 49.47 µM -0.22961719729662 0.378271247617938 no 2120 0.409194621194782 2784 8934436 YOR116C RPO31
SGTC_1350 1495-0454 146 µM -0.230041037291265 0.378115047320657 no 2121 0.409029940772523 2978 1069057
SGTC_2816 7982706 58.44 µM -0.231205754691035 0.377685909683002 no 2122 0.408577479760045 2929 2981853
SGTC_129 0088-0017 176.636 µM -0.231392795652226 0.377617008891977 no 2123 0.408504830774616 2914 182446
SGTC_2364 9055074 200 µM -0.232214502860331 0.377314360518361 no 2124 0.408185706975866 2899 6470630
SGTC_752 1896-0090 130 µM -0.232901831735663 0.377061263762968 no 2125 0.40791881801699 2818 772567
SGTC_35 0133-0054 64.071 µM -0.23311532311893 0.376982660064611 no 2126 0.407835928264726 2851 99677
SGTC_1843 st055809 45.5 µM -0.236545967650865 0.375720259527103 no 2127 0.406504521047228 2966 16413835
SGTC_1151 3909-8316 15.3 µM -0.237921506685168 0.375214464449045 no 2128 0.405970987245275 2931 800431
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.239995325747761 0.374452312705135 no 2129 0.405166940121052 3069 6710655
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.241918639907081 0.37374591129947 no 2130 0.404421603251963 2840 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_426 0988-0037 14.6 µM -0.243075842141268 0.373321094196672 no 2131 0.403973322613196 2982 5383008
SGTC_2569 tetrandrine 100 µM -0.243753268916038 0.373072477445153 no 2132 0.403710957369918 2906 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3290 9121031 71.43 µM -0.244218067799687 0.372901926044261 no 2133 0.403530967286204 2881 17014854
SGTC_2887 9044784 58.44 µM -0.245038391992756 0.372600980432929 no 2134 0.403213352407833 2843 6465546
SGTC_2166 5933061 31.504 µM -0.245137693836146 0.372564555652325 no 2135 0.403174908834952 3342 2877375
SGTC_1054 3429-0080 167 µM -0.245753403553171 0.372338733420967 no 2136 0.40293656476372 3016 1162877
SGTC_503 tyrphostin 8 294 µM -0.245901816169925 0.372284307078027 no 2137 0.402879118945903 2967 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2477 5967686 25.23 µM -0.248130565032981 0.371467280626788 no 2138 0.402016693735737 2829 776118
SGTC_542 3381-0244 89.3 µM -0.25025583753236 0.370688726046942 no 2139 0.401194753264809 3030 1112843
SGTC_101 0490-5701 117.494 µM -0.250302204751612 0.370671746154514 no 2140 0.401176825790738 2815 4661669
SGTC_2879 9041815 71.43 µM -0.250707710434906 0.370523258815745 no 2141 0.401020049485419 2959 4942971
SGTC_1496 4469-0713 57.4 µM -0.25252279141745 0.369858852401501 no 2142 0.400318499897713 2975 746691
SGTC_796 1234-0020 70.7 µM -0.253053379021781 0.369664705225221 no 2143 0.400113482339021 2835 46495034
SGTC_3142 9086498 49.47 µM -0.253711583714109 0.369423907886481 no 2144 0.399859192154289 2986 25236367
SGTC_93 0109-0045 59.227 µM -0.255449769617502 0.36878825707984 no 2145 0.3991878674354 2811 88733
SGTC_2693 st077581 40.7 µM -0.255907266523511 0.368621011028561 no 2146 0.399011221771325 2964 25238761
SGTC_777 1315-0167 517 µM -0.256605771577764 0.368365708209996 no 2147 0.398741559545447 2957 4221767
SGTC_2718 lomofungin 53.02 µM -0.256762029366834 0.368308604111807 no 2148 0.39868124186367 3020 5351222 A RNA synthesis inhibitor.
SGTC_1534 6-azauridine 81.6 µM -0.257258895924501 0.368127044553651 no 2149 0.398489460544043 2843 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_688 0527-0193 473 µM -0.259333676581636 0.367369219507543 no 2150 0.397688898902459 2891 4007154
SGTC_858 0438-0351 2.77 µM -0.259356115937918 0.367361026226134 no 2151 0.397680242943565 2896 2799119
SGTC_449 xestospongin c 11.1929 µM -0.259868078209013 0.367174109871834 no 2152 0.397482767711504 2986 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_87 0100-0052 35.5 µM -0.26142647172688 0.366605337550356 no 2153 0.396881822574068 2931 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1719 st032227 49.2 µM -0.263555497684438 0.365828772963599 no 2154 0.396061226997418 2888 3125804
SGTC_389 tpck 16.7 µM -0.264843606536693 0.365359200381798 no 2155 0.395564971397438 2940 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1802 st050112 57.9 µM -0.265014087650898 0.365297067587727 no 2156 0.395499304671536 2854 4662563
SGTC_911 3456-4043 236 µM -0.265211352392635 0.36522517776328 no 2157 0.395423325003294 2971 914281
SGTC_1192 1488-0095 21.4 µM -0.265499550302333 0.3651201573861 no 2158 0.395312328118457 2950 915875
SGTC_670 4204-0025 119 µM -0.266019338159648 0.364930770360372 no 2159 0.395112157883985 2984 719039
SGTC_3130 9127414 49.47 µM -0.266348777474889 0.36481075473103 no 2160 0.394985305173812 2845 1494646
SGTC_785 1270-0111 65.3 µM -0.267052213997063 0.364554535262497 no 2161 0.394714479725425 2845 6741994
SGTC_2088 5278280 127.392 µM -0.267073594758732 0.364546748488254 no 2162 0.394706248855592 2963 791502
SGTC_464 bw-b 70c 158 µM -0.267652104693263 0.364336079077933 no 2163 0.394483559956404 3007 5353454
SGTC_1373 2887-0003 58.5 µM -0.270268587989116 0.363383776609833 no 2164 0.393476814778591 2952 776948
SGTC_3314 9135860 59.4275 µM -0.272202806416752 0.362680335149536 no 2165 0.392733042038605 3044 25252478
SGTC_2489 cantharidin 73.42 µM -0.273117465991214 0.362347850604389 no 2166 0.392381460518195 2861 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1332 1480-0653 17.5 µM -0.273285933026208 0.362286623084178 no 2167 0.392316713867402 3022 5749438
SGTC_3246 9135460 32.98 µM -0.276403646051706 0.361154161402613 no 2168 0.391119028310813 2994 41446951
SGTC_587 k089-0003 57 µM -0.276582177186293 0.361089349403446 no 2169 0.391050475781001 2885 9659696
SGTC_2665 lovastatin 100 µM -0.276867377375687 0.360985821706146 no 2170 0.390940971404654 2921 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2737 bleomycin 30.5 nM -0.278115497731302 0.360532873781654 no 2171 0.390461849702316 2921 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2654 protoveratrine a 100 µM -0.278413517841739 0.360424749986223 no 2172 0.390347471918331 2899 5702278 A heart drug and vasodilator.
SGTC_1097 itavastatin 7.23 µM -0.279448612547147 0.360049297082362 no 2173 0.389950284458447 2934 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_265 mycophenolic acid 32.932 µM -0.279534340076631 0.360018207762343 no 2174 0.389917394160182 3149 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1705 st027868 56.3335 µM -0.27961352322392 0.359989492602784 no 2175 0.389887015385468 2977 292948
SGTC_2118 5526350 200 µM -0.285075332796058 0.358010724219194 no 2176 0.387793213927535 3010 743594
SGTC_2989 9073649 71.4286 µM -0.286521178063511 0.357487541817909 no 2177 0.387239487664216 2938 21367202
SGTC_704 1310-0270 142 µM -0.290140045862668 0.356179221756327 no 2178 0.38585455030607 2985 5718033
SGTC_2688 kanamycin b 96.69 µM -0.291917011819116 0.355537417926297 no 2179 0.385175038088162 3064 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.292211821869928 0.355430978100595 no 2180 0.385062336681201 2946 688664
SGTC_95 0471-0001 561.058 µM -0.293657317545315 0.354909251783954 no 2181 0.384509886297659 2928 4015405
SGTC_1909 st060837 51.5 µM -0.293861249204681 0.354835668096343 no 2182 0.384431965013355 2971 678937
SGTC_2807 7945238 51.95 µM -0.297134380496446 0.353655382392681 no 2183 0.383181958591992 3029 17148797
SGTC_2382 9035899 200 µM -0.297757696300276 0.353430774715879 no 2184 0.382944052106645 2948 6462679
SGTC_2955 9076254 12.21 µM -0.298017038129735 0.353337337652852 no 2185 0.382845079806066 3049 16459619
SGTC_2002 4023503 131 µM -0.303222744238123 0.351463674185419 no 2186 0.380860058529591 3066 4736863 YCR052W RSC6
SGTC_427 1354-0053 47.3 µM -0.303308414264275 0.351432869423107 no 2187 0.38082741719322 3156 6813657
SGTC_2198 6589944 200 µM -0.303624494363262 0.351319223502146 no 2188 0.380706994116955 2973 5290268
SGTC_83 0170-0301 39.027 µM -0.304496989310937 0.351005588829186 no 2189 0.380374643052241 2910 3089716
SGTC_3161 9100388 49.47 µM -0.304705784789455 0.350930548418045 no 2190 0.380295121692321 2958 25236368
SGTC_2183 6420625 130.508 µM -0.306562559853616 0.35026348557237 no 2191 0.379588177562611 2935 2897619
SGTC_3033 9090887 49.47 µM -0.307632042086193 0.349879474022232 no 2192 0.379181167885008 2939 19325384
SGTC_2342 7990637 118.86 µM -0.307792852195193 0.349821746320703 no 2193 0.379119980428319 3058 2033102 YER133W GLC7
SGTC_1072 oxiconazole 14.9 nM -0.308366054368941 0.349616006137324 no 2194 0.378901904462775 2955 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1709 st033179 39.1045 µM -0.308773310927399 0.349469855855269 no 2195 0.37874698627022 2946 573381
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.309606156297927 0.349171045969969 no 2196 0.378430237071252 3029 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1354 1498-1681 81 µM -0.309757829825603 0.349116638302982 no 2197 0.378372561116138 3043 5754243
SGTC_749 1000-0129 128 µM -0.311411845367656 0.348523518577064 no 2198 0.377743774997248 3114 708470
SGTC_2862 9027634 71.43 µM -0.311668052392427 0.348431677396397 no 2199 0.377646404943925 2918 5012562
SGTC_1540 guanosine 70.6 µM -0.312806273141887 0.348023772888614 no 2200 0.377213924559575 2933 6802 Guanosine is a purine nucleoside
SGTC_1382 3002-2117 298 µM -0.314178828131717 0.347532123772155 no 2201 0.376692610926037 3119 1497314
SGTC_2036 5160441 105 µM -0.31430115796697 0.347488317662891 no 2202 0.376646159412733 3022 134534 YIL048W NEO1
SGTC_751 0833-0568 350 µM -0.318018114628637 0.346158255264379 no 2203 0.375235598095326 3058 6954252
SGTC_3346 9158254 43.5805 µM -0.318133099106192 0.34611713977472 no 2204 0.375191988702369 3056 17639500
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.318681355760506 0.345921122257106 no 2205 0.374984077017223 2942 3256 An antibiotic and ribosome inhibitor.
SGTC_2563 tomatine 8.54 µM -0.320981151222442 0.345099329603296 no 2206 0.374112337446412 3169 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2767 sibutramine 71.45 µM -0.321275527874143 0.344994191751092 no 2207 0.374000800060545 3175 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2515 chrysin 20.77 µM -0.321353889549686 0.344966206567229 no 2208 0.373971111112079 3040 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_293 4049-0273 38.5 µM -0.322783810762002 0.344455690080151 no 2209 0.373429487214983 3012 1380311
SGTC_2126 5251174 33.877 µM -0.323256005386265 0.344287167329104 no 2210 0.373250684728686 3146 790722
SGTC_1025 k007-0731 70 µM -0.323897582959115 0.344058242602132 no 2211 0.3730077869766 2961 6256118
SGTC_1262 0737-0114 49.6 µM -0.323910199246855 0.34405374148962 no 2212 0.373003011024922 3144 765919
SGTC_2686 alizarin 95.37 µM -0.323975274258951 0.344030525030887 no 2213 0.372978376900457 3024 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2958 9077254 16.72 µM -0.325077484160656 0.343637384967164 no 2214 0.372561214672882 3180 16457351
SGTC_1761 st044296 37 µM -0.325104053264474 0.343627910291843 no 2215 0.372551160693717 2951 1826700
SGTC_52 0329-0193 875 nM -0.325384359917903 0.34352795752329 no 2216 0.372445095518934 3179 3739292
SGTC_3018 9082602 49.47 µM -0.327299266535779 0.34284542610999 no 2217 0.37172077356763 2995 17332089
SGTC_2532 xanthone 78.9 µM -0.327322651210252 0.342837094258937 no 2218 0.371711931010476 3083 7020 An insecticide.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.328256696570414 0.342504360768749 no 2219 0.371358791426173 3059 6708739 YPR165W RHO1
SGTC_2398 5228213 48.84 µM -0.329746423742094 0.341973930553404 no 2220 0.370795786348554 3196 80771 YMR134W ERG29
SGTC_1286 0929-0070 131 µM -0.329815752710545 0.341949252959616 no 2221 0.370769591925763 3086 1420408
SGTC_1893 st059353 36.1 µM -0.331215613000924 0.3414511183335 no 2222 0.370240813862439 3052 3112488
SGTC_1885 st057546 99.9 µM -0.331562970422243 0.341327555316163 no 2223 0.370109642272438 3151 702008
SGTC_722 3534-0461 190 µM -0.333009389769199 0.340813213715471 no 2224 0.369563597648083 3022 658262
SGTC_2785 7756463 72.73 µM -0.334618538078409 0.340241353846596 no 2225 0.368956429476 2978 2201551
SGTC_2078 5212016 200 µM -0.334660612160329 0.340226406461022 no 2226 0.368940558348724 3033 1899708
SGTC_2634 4'-methoxyflavone 100 µM -0.335479589030426 0.339935503903352 no 2227 0.368631669562295 3050 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1367 1812-0510 76.9 µM -0.335645545422914 0.339876567397455 no 2228 0.368569087079869 3040 1142582 YDR527W RBA50
SGTC_2263 7948595 193.29 µM -0.335999156725115 0.3397510015923 no 2229 0.368435751190313 2963 2971371
SGTC_180 1486-1293 102.781 µM -0.336194839648744 0.33968152309526 no 2230 0.368361972017396 3141 4140536
SGTC_311 1315-0136 58 µM -0.338017534133676 0.339034625476592 no 2231 0.367674987177453 3175 6759207
SGTC_206 4546-0025 72.014 µM -0.339365717601955 0.338556442929824 no 2232 0.367167120596427 3086 6620745 YIL048W NEO1
SGTC_955 1216-0110 33 µM -0.342121992881818 0.337579639464712 no 2233 0.366129543550432 2964 3619719
SGTC_1803 st050068 52.4 µM -0.343499185114133 0.337091981946816 no 2234 0.365611476881574 3106 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1035 k081-0041 55.2 µM -0.346759900897571 0.33593846939518 no 2235 0.364385852255871 3166 731709
SGTC_1258 0671-0043 57.1 µM -0.347143957517053 0.33580270672818 no 2236 0.364241585561762 3063 4298767
SGTC_2179 6298986 200 µM -0.348153912613745 0.33544579343745 no 2237 0.363862298746063 3156 738374
SGTC_455 paf C-16 10 µM -0.34823441299186 0.33541735137338 no 2238 0.363832072707392 3007 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1790 st045711 43.5 µM -0.348316610254793 0.335388310746165 no 2239 0.363801210401833 3181 585119
SGTC_2297 7971671 152.32 µM -0.348716329850079 0.33524710221168 no 2240 0.363651141747416 3195 909016
SGTC_3322 9139058 2.11 µM -0.352310198254203 0.33397854750187 no 2241 0.362302820372363 3198 4908926 YPR165W RHO1
SGTC_2944 9067346 25.62 µM -0.352693971268594 0.333843195975485 no 2242 0.362158939760559 3181 6473075
SGTC_3248 9135562 49.47 µM -0.357164675370465 0.332268035955419 no 2243 0.360484264553821 3079 17650701
SGTC_975 1335-0046 28.5 µM -0.358069263378773 0.331949682057998 no 2244 0.360145740181985 3041 16486740
SGTC_1449 4112-4002 201 µM -0.359260697923877 0.331530562638312 no 2245 0.359700036433056 3076 2059539
SGTC_948 3448-0295 75.3 µM -0.359731520413879 0.331364996151599 no 2246 0.359523958996888 3030 678569
SGTC_330 1488-0319 80.1 µM -0.360963658343971 0.330931866276696 no 2247 0.359063307256696 3111 6846614
SGTC_1863 st057641 20.1 µM -0.361141761325773 0.330869276949798 no 2248 0.358996737932854 3112 3921635
SGTC_190 3970-0790 3.722 µM -0.361349056450513 0.330796434811417 no 2249 0.358919262891009 3124 2832352
SGTC_2903 5923464 63.88 µM -0.362062591829108 0.330545752182419 no 2250 0.358652628628237 3139 2876576
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.363866225003765 0.329912430311162 no 2251 0.357978953419801 3003 6312947
SGTC_2238 6671620 73.2395 µM -0.365078422891493 0.329487056739329 no 2252 0.357526433491215 2970 729941
SGTC_348 k064-0012 10.7 µM -0.365676359874903 0.329277315263796 no 2253 0.357303294132264 2995 5066323
SGTC_113 0099-0221 2.5 µM -0.370888538636681 0.327451293120396 no 2254 0.355360276074805 3242 89219
SGTC_279 1273-0055 2.93 µM -0.375004031422009 0.326012389500549 no 2255 0.3538287342236 3131 2847562
SGTC_1913 st060213 96.1 µM -0.375396604290991 0.325875268704499 no 2256 0.353682764971793 3237 688959
SGTC_3027 9089541 49.47 µM -0.380692076622747 0.324027933995924 no 2257 0.351715874446634 3167 9943819
SGTC_1335 1486-0900 202 µM -0.38110180345124 0.323885179782638 no 2258 0.351563854629683 3030 X1335
SGTC_1398 3558-0053 112 µM -0.38190298786251 0.323606111456047 no 2259 0.351266661988553 3003 4532369
SGTC_1282 0886-0010 32.4 µM -0.382686651152224 0.323333242016037 no 2260 0.350976056618218 3257 2836211 YNL267W PIK1
SGTC_1700 st030840 7.9285 µM -0.38277486068987 0.323302533639465 no 2261 0.350943351383621 3179 5499307
SGTC_3126 9127922 49.47 µM -0.383634843574422 0.323003210998712 no 2262 0.350624555527482 3277 45595682
SGTC_3082 9117008 49.47 µM -0.386589549815127 0.321975680427987 no 2263 0.349530047809075 3116 41448529
SGTC_550 4123-0385 25.7 µM -0.387066708378749 0.321809870759268 no 2264 0.34935341159813 3083 5731123
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.387318889750299 0.321722253609972 no 2265 0.349260071397523 3114 2374 Ca(2+)-ATPase inhibitor.
SGTC_3047 9092122 49.47 µM -0.388047716220081 0.321469088039786 no 2266 0.348990361226647 3143 17173831
SGTC_2434 5670830 169.91 µM -0.390797635528608 0.320514621854109 no 2267 0.347973411423433 3175 1549830
SGTC_2143 5623677 140.463 µM -0.391083730247409 0.320415389576211 no 2268 0.347867673131655 3174 5375313
SGTC_1298 1079-1278 263 µM -0.391674157879907 0.320210639673916 no 2269 0.347649493266796 3140 2840950
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.392054222590086 0.320078868877997 no 2270 0.347509075192434 3113 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1155 4088-0394 48.2 µM -0.392160313013961 0.320042090719547 no 2271 0.3474698829356 3068 2326248
SGTC_658 3253-0951 102 µM -0.392688026676546 0.319859175544279 no 2272 0.347274957535196 3138 1184878
SGTC_334 1502-1024 68.5 µM -0.393094824687549 0.319718201826617 no 2273 0.347124723186502 3191 3296216
SGTC_90 0870-0863 4.608 µM -0.393323694748193 0.319638899552641 no 2274 0.347040209868982 3057 1738164
SGTC_2516 gossypol 71.55 µM -0.396004663737486 0.318710572699063 no 2275 0.34605079386105 3232 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2161 5662504 8.5105 µM -0.396054101160039 0.318693464884311 no 2276 0.346032558739139 3115 2859334
SGTC_2211 7117706 200 µM -0.396460105514042 0.318552981741982 no 2277 0.345882816486745 3186 822771
SGTC_2005 4024620 188 µM -0.396533700622581 0.318527519604439 no 2278 0.345855675768107 3101 236743
SGTC_1044 1222-0021 1.78 µM -0.39784059159088 0.318075509587959 no 2279 0.345373846959962 3167 4306703
SGTC_146 3448-8650 53.125 µM -0.398269943076098 0.317927070294765 no 2280 0.345215606882287 3108 2891488 YIL048W NEO1
SGTC_2441 5730946 39.09 µM -0.398893179089337 0.31771165153115 no 2281 0.344985957641855 3231 1774275
SGTC_1569 carminic acid 40.6 µM -0.39910087749258 0.317639875201466 no 2282 0.34490943786763 3272 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1860 st056228 74.6 µM -0.399552034891301 0.317483988026915 no 2283 0.344743245338828 3224 688679
SGTC_591 4299-0174 154 µM -0.399613239980293 0.317462842493302 no 2284 0.344720701570827 3141 5509088
SGTC_2859 9028643 45.46 µM -0.40040935826795 0.317187848634986 no 2285 0.344427516308954 3150 17151580
SGTC_185 k048-0037 25.491 µM -0.400750944847794 0.317069889293207 no 2286 0.344301749381891 3232 6827589
SGTC_1318 1280-3875 124 µM -0.403788853714089 0.316021633751781 no 2287 0.343183996835414 3167 373245
SGTC_1002 4049-0206 172 µM -0.404558876236653 0.315756165494168 no 2288 0.342900896053505 3104 4662749
SGTC_3006 9075424 71.4286 µM -0.407487848961296 0.314747259789822 no 2289 0.34182485841795 3133 7465181
SGTC_1206 3978-0017 132 µM -0.408186938797497 0.314506657176772 no 2290 0.341568218235678 3359 3873677
SGTC_3152 9099253 49.47 µM -0.408967604836351 0.314238071928734 no 2291 0.341281717471509 3155 25236131
SGTC_3124 9127567 49.47 µM -0.41183392995954 0.31325276759726 no 2292 0.340230575093709 3286 17592030
SGTC_1523 st012844 44.7 µM -0.412401830865724 0.313057708491064 no 2293 0.34002246071535 3261 4274103
SGTC_1934 st074720 32.6 µM -0.413388827923628 0.312718825297413 no 2294 0.339660879305932 3081 17250992
SGTC_902 1120-0002 2.07 µM -0.41380989613643 0.312574300622297 no 2295 0.339506667951826 3121 3280475
SGTC_1677 st019204 53.9 µM -0.414278613189677 0.312413455166966 no 2296 0.339335037363433 3208 3945625
SGTC_2395 5646831 180.19 µM -0.418765885443891 0.310875410113561 no 2297 0.337693619559985 3308 6808628
SGTC_1238 0333-0287 48.8 µM -0.419414647192027 0.310653314608987 no 2298 0.337456560651355 3173 7226
SGTC_1116 jasmonic acid 1.58368 µM -0.421316412819505 0.310002666579506 no 2299 0.336762023423498 3275 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2544 sphondin 68.51 µM -0.423505003242227 0.309254623442294 no 2300 0.3359634244792 3314 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1117 retinoic acid 1.10837 µM -0.423533680922812 0.309244826871626 no 2301 0.335952965129459 3293 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_556 4058-0063 51.5 µM -0.426472732546605 0.308241538825476 no 2302 0.334881706483942 3202 6615692
SGTC_2839 9003951 25.97 µM -0.427587770039822 0.307861278527708 no 2303 0.334475635770201 3263 2990634
SGTC_2909 7941780 10.49 µM -0.427629165695848 0.307847165370227 no 2304 0.334460564159107 3306 1243215
SGTC_3176 9106582 49.47 µM -0.427841504323347 0.307774776531004 no 2305 0.33438325866666 3196 17018027
SGTC_22 0964-0034 14.468 µM -0.428924944472571 0.307405535038851 no 2306 0.333988923227914 3213 138402
SGTC_2716 st080858 38.6235 µM -0.430881061986974 0.306739375280624 no 2307 0.333277427104914 3285 5296050
SGTC_3315 9136395 68.55 µM -0.431145324375749 0.306649429047801 no 2308 0.333181353195546 3344 16876844
SGTC_2325 6158266 200 µM -0.432303363612725 0.306255407909821 no 2309 0.332760471406688 3207 3623240
SGTC_38 0929-0051 58.268 µM -0.432896654048789 0.306053628453079 no 2310 0.332544925454012 3262 1379719
SGTC_361 000s-0510 1.45 µM -0.43432409306397 0.305568394275547 no 2311 0.332026555264267 3224 660
SGTC_1336 1486-0901 104 µM -0.434760900749753 0.305419976918455 no 2312 0.3318679940245 3221 5006114
SGTC_643 k048-0106 28.4 µM -0.43492541754592 0.305364086125951 no 2313 0.331808282212981 3262 6763920
SGTC_871 0574-0004 149 µM -0.43543480150419 0.3051910634324 no 2314 0.331623427040914 3141 9551173
SGTC_1144 3486-0183 12.5 µM -0.436969078223926 0.304670178029 no 2315 0.331066886689245 3199 6744069
SGTC_2030 5175110 200 µM -0.437658834981143 0.304436135191404 no 2316 0.330816807228058 3288 2831986
SGTC_1646 st011709 75.6 µM -0.439788092401139 0.303714157649231 no 2317 0.33004529637108 3270 5757843
SGTC_3293 9120939 62.045 µM -0.441874683774347 0.303007389368296 no 2318 0.329289945587075 3291 934087
SGTC_2254 7938975 95.19 µM -0.441976150829079 0.302973039313641 no 2319 0.329253232011583 3358 2969277
SGTC_2617 dihydrotanshinone i 20.83 µM -0.443320759690906 0.302518008073891 no 2320 0.328766871073386 3176 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1807 st050092 58.9 µM -0.443481840220365 0.302463517108692 no 2321 0.328708625765817 3178 5008496
SGTC_2120 5538279 151.968 µM -0.443558091396631 0.302437724090887 no 2322 0.328681055459697 3207 2058197
SGTC_2004 4023728 41.89 µM -0.445238172746227 0.301869663753302 no 2323 0.32807382158304 3324 360084 YDR527W RBA50
SGTC_1316 1272-0050 65.9 µM -0.44905118730053 0.300582209625865 no 2324 0.326697365834086 3240 7340392
SGTC_2917 7979103 53.79 µM -0.449083040118237 0.300571465055829 no 2325 0.326685877217574 3310 2980565
SGTC_1982 st072467 71.9 µM -0.449498517110413 0.300431332535876 no 2326 0.326536038784894 3142 3163533
SGTC_2286 7945697 125 µM -0.449895770759862 0.300297374011986 no 2327 0.326392798620463 3234 1245733
SGTC_3231 9132313 49.47 µM -0.449978330825752 0.300269537191857 no 2328 0.32636303264758 3244 4905967
SGTC_2257 7960413 200 µM -0.453592991509514 0.299051925502361 no 2329 0.325060899399687 3172 2974689 YIL048W NEO1
SGTC_1841 st054148 70 µM -0.453641924017166 0.299035457797088 no 2330 0.32504328672102 3251 675442
SGTC_1410 3909-8106 77.9 µM -0.453647026110135 0.299033740766685 no 2331 0.325041450305374 3297 1039210
SGTC_2469 5655019 90.81 µM -0.454260835306634 0.298827205458302 no 2332 0.324820550662509 3319 2788239
SGTC_1701 st028638 40.4 µM -0.45453661711543 0.298734431149603 no 2333 0.324721321458292 3314 3490878
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.455019241502914 0.298572105529321 no 2334 0.324547698045047 3438 6728940
SGTC_1143 3454-2408 5.08 µM -0.456554446791317 0.298056022403766 no 2335 0.323995663870486 3278 X1143
SGTC_1407 3909-7909 12.3 µM -0.458487650021718 0.297406724950545 no 2336 0.323301066607569 3243 4411780
SGTC_3205 9113483 49.47 µM -0.462663875128838 0.296006282522656 no 2337 0.321802657977278 3343 17018033
SGTC_1060 3448-7350 82 µM -0.463282504288249 0.295799091017498 no 2338 0.321580942402896 3328 570178
SGTC_2825 7998094 58.44 µM -0.46464514205808 0.295342951033198 no 2339 0.321092799679839 3237 2987815
SGTC_34 0469-0683 81.75 µM -0.466419506952618 0.294749471917057 no 2340 0.320457625650402 3284 3690923
SGTC_1347 1493-0251 600 nM -0.467031982288601 0.294544742518635 no 2341 0.320238498168839 3325 3986378
SGTC_2232 chlorophetanol 41.5365 µM -0.467334109119726 0.294443776104286 no 2342 0.320130428255377 3330 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2669 eugenol 100 µM -0.467800937976736 0.29428780007872 no 2343 0.319963474896967 3270 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2692 st077426 47.7 µM -0.468816176962395 0.293948722046189 no 2344 0.319600517922943 3358 25238571
SGTC_3317 9138495 8.753 µM -0.469611260451135 0.29368329960217 no 2345 0.319316389077685 3293 17020139
SGTC_289 k017-0060 526 µM -0.47152172370502 0.293045984255535 no 2346 0.318634105093963 3233 5512909
SGTC_2865 9030313 51.95 µM -0.474992216143663 0.29188989984728 no 2347 0.317396260675607 3175 42562754
SGTC_869 0564-0080 44.1 µM -0.475104161996304 0.29185264403103 no 2348 0.317356366059854 3275 6843321
SGTC_1329 1447-1697 50.6 µM -0.475500494023687 0.291720761701941 no 2349 0.317215140599468 3308 2840515
SGTC_2137 5261020 140 µM -0.476440842502284 0.291407965164951 no 2350 0.316880171620229 3232 763655
SGTC_3188 9110789 49.47 µM -0.476857933236032 0.29126927465148 no 2351 0.316731644446916 3383 849217
SGTC_883 0850-0245 24.6 µM -0.477399491233821 0.291089242419676 no 2352 0.316538838212114 3393 6823229 YPR165W RHO1
SGTC_2724 maprotiline 69.64 µM -0.477735615702607 0.290977529401142 no 2353 0.316419195773884 3359 4011 A tricyclic antidepressant.
SGTC_1815 st051655 58.2 µM -0.478412755406051 0.290752538736263 no 2354 0.316178228387802 3317 5984156
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.478416861529213 0.290751174658326 no 2355 0.316176767418068 3305 1241132 A phosphatase inhibitor.
SGTC_1251 0490-5699 265 µM -0.479733324115373 0.290313992514924 no 2356 0.315708514535086 3420 3883818
SGTC_1040 k898-0338 155 µM -0.480444763909953 0.290077859720267 no 2357 0.315455585361855 3394 20969351
SGTC_1130 3454-2858 15.9 µM -0.481128231710283 0.289851095880188 no 2358 0.31521268212333 3263 715628 YIL048W NEO1
SGTC_3282 9108498 15.4605 µM -0.482075610289228 0.289536908188206 no 2359 0.314876117554999 3305 16459645
SGTC_1051 3253-3903 78 µM -0.482700619302785 0.289329718412383 no 2360 0.314654161729245 3194 5509239
SGTC_2401 5128683 200 µM -0.484056831551501 0.288880375369001 no 2361 0.314172768291418 3252 708373
SGTC_1795 st049545 62.3 µM -0.485399615395753 0.28843580528819 no 2362 0.313696452568571 3336 5291882
SGTC_1397 3532-0190 20.1 µM -0.486217037965299 0.28816533029429 no 2363 0.313406646270385 3190 5322280
SGTC_367 0335-0881 7.1 µM -0.487986536878112 0.287580235284329 no 2364 0.312779688631343 3376 23828853
SGTC_3328 9140624 29.0385 µM -0.489134635526505 0.287200910497114 no 2365 0.312373190957881 3370 4904392
SGTC_277 nystatin 15.5 µM -0.490418811579613 0.286776907372471 no 2366 0.311918783907558 3205 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_625 k213-0058 121 µM -0.490431059701592 0.286772864774879 no 2367 0.311914451273106 3330 3655420
SGTC_2160 5660466 132.927 µM -0.491034127595813 0.286573850467428 no 2368 0.311701155032479 3348 2859134
SGTC_3284 9108171 64.8615 µM -0.491430005197214 0.286443245237765 no 2369 0.311561173281156 3305 8687505
SGTC_2295 7971645 200 µM -0.491681553994269 0.286360270659151 no 2370 0.311472240135295 3259 2978226 YKL099C UTP11
SGTC_422 cantharidin 155 µM -0.494425379657149 0.285455948374138 no 2371 0.310502896845214 3236 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1045 1348-1485 165 µM -0.495475760616179 0.28511011940277 no 2372 0.310132164042757 3302 6810614
SGTC_1875 nocodazole 6 µM -0.495929560647824 0.284960771419307 no 2373 0.309972054609624 3387 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_340 k038-0059 454 µM -0.497970329300033 0.284289605276883 no 2374 0.309252477624721 3349 23733424
SGTC_3223 9129970 49.47 µM -0.499589394243533 0.283757666777404 no 2375 0.308682113612059 3279 17248386
SGTC_971 1315-0384 26.7 µM -0.500468588729492 0.283469010111904 no 2376 0.308372584212568 3291 6769120
SGTC_337 1315-0038 354 µM -0.502316970220722 0.282862609876876 no 2377 0.307722286897493 3305 1626437
SGTC_2167 5876490 200 µM -0.502458232752972 0.282816291384802 no 2378 0.307672612736167 3422 686534
SGTC_2543 pimpinellin 60.67 µM -0.503748375786299 0.282393435777422 no 2379 0.307219104551409 3242 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2148 5546263 113.568 µM -0.504383238509445 0.282185465699637 no 2380 0.306996047164935 3254 792097
SGTC_1184 1269-1718 139 µM -0.504496485963633 0.282148375536706 no 2381 0.306956265466683 3405 5403821
SGTC_1494 4358-1428 177 µM -0.504754865509864 0.282063761321983 no 2382 0.306865510106049 3414 1564571
SGTC_1303 1160-0052 261 µM -0.505187542497625 0.281922095495863 no 2383 0.306713559582413 3362 3562476
SGTC_1891 st059073 26.2 µM -0.506307984383021 0.281555403105842 no 2384 0.306320229385517 3408 688754
SGTC_588 3970-1144 52.9 µM -0.507043082137969 0.281314949182698 no 2385 0.306062295087832 3365 1888707
SGTC_737 1950-0117 57.9 µM -0.50761720341127 0.281127220391482 no 2386 0.305860911764882 3391 5393513
SGTC_1175 0741-0056 27.6 µM -0.507840955765662 0.281054073217098 no 2387 0.30578244250646 3440 765927
SGTC_308 4092-1169 104 µM -0.508702920435747 0.280772373194293 no 2388 0.305480237521234 3312 2268590 YDL196W YDL196W
SGTC_176 1486-1328 72.834 µM -0.510335968244799 0.280239048967383 no 2389 0.304908054034005 3350 22310231
SGTC_1750 st081859 2.357 µM -0.510859860382097 0.280068059188069 no 2390 0.3047245948593 3414 5291695
SGTC_3106 9121286 49.47 µM -0.510923964955886 0.280047139982156 no 2391 0.304702149768699 3450 15943471
SGTC_1937 st074714 47.2 µM -0.511540039598183 0.279846135351011 no 2392 0.304486479543943 3262 17250970
SGTC_43 0570-0105 72.5 µM -0.513470556616376 0.279216725558216 no 2393 0.303811100794969 3352 1114046 YDL195W SEC31
SGTC_2445 5742597 35.57 µM -0.513500124804532 0.279207090743163 no 2394 0.303800761755934 3262 1774255
SGTC_1346 1488-2224 62.4 µM -0.51513405015594 0.278674926350913 no 2395 0.30322967511045 3403 3722427
SGTC_1217 1183-1422 255 µM -0.515490382231055 0.278558935733439 no 2396 0.303105194344431 3396 2849664
SGTC_3001 9076041 71.4286 µM -0.516530771413594 0.278220410456343 no 2397 0.302741876479479 3350 16004211
SGTC_1411 3909-8223 150 µM -0.516943536900867 0.278086159058639 no 2398 0.302597787298158 3394 X1411
SGTC_1024 4507-0395 26 µM -0.519656147252169 0.277204673422641 no 2399 0.301651628366371 3467 4201836
SGTC_439 amiodarone 34.4 µM -0.520357983506667 0.276976828590029 no 2400 0.301407044588766 3269 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1965 Pectolinarigenin 58.4 µM -0.521506857245741 0.276604055045397 no 2401 0.30100686496026 3324 5320438 An anti-inflammatory.
SGTC_2294 7971431 200 µM -0.521850966409209 0.276492450275964 no 2402 0.300887050310616 3362 5741572
SGTC_2999 9069765 71.4286 µM -0.5226909281042 0.276220118639988 no 2403 0.300594676176356 3337 2097066
SGTC_2008 4012253 172 µM -0.522984165834257 0.276125076371591 no 2404 0.30049263610839 3323 603940
SGTC_1142 3253-1408 9.78 µM -0.524532354954063 0.275623553863046 no 2405 0.299954161009581 3423 256655
SGTC_108 0509-0257 621.132 µM -0.525189720443809 0.275410741524185 no 2406 0.299725655101921 3340 536624
SGTC_278 4092-0821 23.9 µM -0.527038361973352 0.27481270491926 no 2407 0.299083474412609 3394 877900
SGTC_3320 9137005 35.139 µM -0.527760792996561 0.274579172148164 no 2408 0.298832686342631 3343 4908713
SGTC_258 haloperidol 50.781 µM -0.52895790322741 0.274192410408858 no 2409 0.298417326425749 3357 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_923 1900-2434 73.3 µM -0.530113091550861 0.273819448058375 no 2410 0.298016761379648 3392 5910570
SGTC_819 1013-0258 27.7 µM -0.531261459517812 0.273448936532586 no 2411 0.297618804367672 3362 5753198
SGTC_2513 baicalein 25.65 µM -0.531326248075492 0.273428040433551 no 2412 0.297596359681369 3353 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3068 9116768 49.47 µM -0.531522001825071 0.273364909246803 no 2413 0.297528549445506 3408 41904888
SGTC_870 0573-2213 57.6 µM -0.531557198833848 0.273353558868784 no 2414 0.29751635774548 3426 3916321
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.533047556318157 0.272873160689485 no 2415 0.297000330388024 3390 16623 A steroid.
SGTC_275 trichlorophene 5.69 µM -0.533324188664087 0.272784037792669 no 2416 0.296904593159963 3417 62616
SGTC_157 1348-1695 65.819 µM -0.534460645453655 0.272418056056713 no 2417 0.296511435188632 3424 5380510
SGTC_812 4251-0442 148 µM -0.53468956445221 0.272344365068862 no 2418 0.296432269386311 3420 5723007
SGTC_2144 5628481 200 µM -0.536278984370387 0.271832990410296 no 2419 0.29588287635744 3355 2818399
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.537224077270053 0.271529146048348 no 2420 0.295556420883175 3426 4213774
SGTC_731 3966-0296 387 µM -0.538524181816105 0.27111144315138 no 2421 0.295107607538728 3404 660956
SGTC_2077 5212015 200 µM -0.540220937968776 0.270566784849687 no 2422 0.294522337371889 3364 780900
SGTC_1371 2421-0008 32.7 µM -0.540794067117127 0.270382934111409 no 2423 0.294324766303795 3329 2827552
SGTC_372 0155-0182 15.9 µM -0.541205781041329 0.27025090136619 no 2424 0.294182876638259 3406 771486
SGTC_429 1112-0049 25.5 µM -0.541669048804761 0.270102374351089 no 2425 0.294023257684954 3277 2836170
SGTC_2661 dactinomycin 12.96 µM -0.541677625135751 0.270099625102014 no 2426 0.29402030308677 3378 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2350 9023895 38.85 µM -0.542984977059699 0.269680701042936 no 2427 0.293570073009605 3443 2997209
SGTC_1427 4048-4900 550 nM -0.544168129081109 0.269301856000022 no 2428 0.293162890687133 3446 24132586
SGTC_602 3130-1533 38.1 µM -0.544788797177355 0.269103224981534 no 2429 0.292949392246341 3461 720941
SGTC_2451 5856223 45.7 µM -0.54504731439183 0.269020513989936 no 2430 0.292860488355636 3366 2179896
SGTC_913 3487-1245 167 µM -0.547248683439771 0.268316716863557 no 2431 0.292103946963486 3340 4016153
SGTC_2463 5473429 200 µM -0.550461568217593 0.267291194204217 no 2432 0.291001414900571 3379 5399405
SGTC_3007 9078383 71.4286 µM -0.551230229510665 0.267046138247505 no 2433 0.290737929945766 3350 6496995
SGTC_2533 agelasine 13.65 µM -0.552925500407714 0.266506072352117 no 2434 0.290157212550642 3519 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_631 k072-0230 41.5 µM -0.55303424370411 0.266471448642767 no 2435 0.290119980940974 3442 5773147
SGTC_2770 toltrazuril 17.5 µM -0.553074688472794 0.266458571667063 no 2436 0.290106134002593 3464 68591 Kills coccidiodes.
SGTC_355 1311-2252 105 µM -0.553173479146594 0.26642711960002 no 2437 0.290072312676736 3365 5338538
SGTC_733 4069-0007 56.1 µM -0.554558118170046 0.265986488684636 no 2438 0.289598471354839 3475 5717425 YNL287W SEC21
SGTC_1154 4088-0362 150 µM -0.554719535708013 0.265935145140475 no 2439 0.289543255851949 3441 6618304
SGTC_914 3820-6779 408 µM -0.554940687112106 0.265864809655874 no 2440 0.289467615432246 3367 2893481
SGTC_3283 9109332 35.8195 µM -0.55585614052207 0.265573757132617 no 2441 0.289154601651921 3337 17027281
SGTC_1758 st042942 75.2445 µM -0.555945700392756 0.265545291807267 no 2442 0.289123987698544 3438 669317
SGTC_64 000l-0018 272.079 µM -0.556023901173486 0.2655204380721 no 2443 0.289097257831702 3422 6811119
SGTC_284 0988-0104 32.6 µM -0.556078075717009 0.265503221036231 no 2444 0.28907874107227 3429 4666532
SGTC_477 mead ethanolamide 10 µM -0.557047760229754 0.26519514457561 no 2445 0.288747399072822 3351 16061185
SGTC_1691 st019933 84.6 µM -0.557907834620693 0.264922044106652 no 2446 0.288453660670025 3440 6176082
SGTC_2932 9016711 44.54 µM -0.558210781740959 0.264825882988698 no 2447 0.288350229678876 3465 7117328
SGTC_2010 4012422 159 µM -0.563029020318169 0.263298872446684 no 2448 0.286707561451531 3393 952393
SGTC_917 harmaline 728.087 nM -0.563082648461268 0.263281901792378 no 2449 0.286689303156144 3409 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3011 9081274 71.4286 µM -0.564044425382009 0.26297764185146 no 2450 0.286361949192505 3399 6625322
SGTC_2282 7944268 200 µM -0.564808260234114 0.262736129377226 no 2451 0.286102094004761 3524 2970414
SGTC_1170 0310-0127 64.8 µM -0.567167646219057 0.261990846082824 no 2452 0.285300143560427 3407 774975
SGTC_2048 5246248 200 µM -0.568362819542506 0.261613728503649 no 2453 0.284894315634896 3495 677046
SGTC_825 1988-2224 89.6 µM -0.569368288951198 0.261296684842795 no 2454 0.284553116181479 3404 1180859
SGTC_1315 1237-0019 3.69 µM -0.56942692625212 0.261278201477641 no 2455 0.284533224021614 3486 825140
SGTC_1606 st000094 49.2 µM -0.570219356822467 0.2610284812554 no 2456 0.28426446446553 3521 1242210
SGTC_1581 himbacine 57.9 µM -0.572668635096227 0.260257411837122 no 2457 0.283434539033186 3397 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3090 9117696 49.47 µM -0.573072859598354 0.260130268850598 no 2458 0.283297681369084 3384 7923821
SGTC_45 0kpi-0036 14.9 µM -0.574653116683599 0.259633529212442 no 2459 0.28276296050712 3498 2795021
SGTC_338 4055-0136 114 µM -0.576862652058726 0.2589398035065 no 2460 0.282016121012795 3436 2900563
SGTC_1630 st005209 31.3 µM -0.57945552714767 0.258126945504427 no 2461 0.2811409232059 3517 3367314
SGTC_1205 4161-2785 76 µM -0.580015604352277 0.257951537026303 no 2462 0.28095204744775 3447 3498106
SGTC_624 k048-0052 28 µM -0.580619123066169 0.257762592505092 no 2463 0.28074859050796 3437 6835531
SGTC_567 1080-0542 68.4 µM -0.581076471522401 0.257619457588986 no 2464 0.280594457646713 3470 5950415
SGTC_78 0336-0123 156.75 µM -0.581123790821191 0.257604650572424 no 2465 0.280578512715187 3313 6765896
SGTC_1742 st038235 28.8875 µM -0.58180858340187 0.257390416768051 no 2466 0.280347810912078 3445 564103 YBR002C RER2
SGTC_2784 7567673 72.73 µM -0.582287018995173 0.257240795629132 no 2467 0.280186683853149 3524 3471247
SGTC_3091 9116372 49.47 µM -0.582375463155584 0.257213141443752 no 2468 0.280156902632167 3527 17169793
SGTC_2201 6605497 169.863 µM -0.582741984450468 0.257098556257109 no 2469 0.280033502676432 3468 670741
SGTC_214 4373-3496 70 µM -0.583072271284011 0.256995321758425 no 2470 0.27992232467055 3560 3779166
SGTC_2400 5203494 178.7 µM -0.583762263390055 0.256779727329105 no 2471 0.279690135191864 3481 6777674
SGTC_3351 9150312 21.596 µM -0.584392483270659 0.256582891582254 no 2472 0.279478141389058 3462 4904905
SGTC_396 dithiazanine 1.25 µM -0.584663114351745 0.256498389857736 no 2473 0.27938713027241 3409 10578 An antihelmenthic.
SGTC_2035 5154463 94.595 µM -0.585481328663679 0.25624299920014 no 2474 0.279112058791746 3510 2769623
SGTC_778 3456-2434 196 µM -0.586721340172457 0.255856205095473 no 2475 0.27869543652445 3499 5539063
SGTC_2184 6075246 200 µM -0.588377037829052 0.255340222384902 no 2476 0.278139623410914 3482 2267320
SGTC_530 4358-1714 28 µM -0.588611912582431 0.255267069937591 no 2477 0.278060820416262 3493 1564641
SGTC_682 0kpi-0099 17 µM -0.589029265373464 0.255137111194105 no 2478 0.277920820964749 3510 1714895 YML126C ERG13
SGTC_188 3229-0966 278.469 µM -0.589764193221715 0.254908347461867 no 2479 0.277674375796242 3543 5722370
SGTC_2595 hexamethylquercetagetin 100 µM -0.589964457747373 0.254846028992076 no 2480 0.277607239110604 3423 386331
SGTC_2608 thymoquinone 42.66 µM -0.591813926338915 0.254270887030521 no 2481 0.276987598292583 3476 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1406 3909-7906 11.9 µM -0.592905575264476 0.253931729119618 no 2482 0.276622173312507 3527 X1406
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.593442110104382 0.253765123359906 no 2483 0.276442657130484 3413 88881 An O-methylated flavonoid and antioxidant.
SGTC_31 0508-1974 57.237 µM -0.594365993899034 0.253478371865669 no 2484 0.276133673984197 3492 6810525
SGTC_319 1348-1596 45.5 µM -0.594809357788613 0.253340822773584 no 2485 0.275985455850737 3555 5380505
SGTC_1739 st037196 92.5 µM -0.596093791719985 0.252942561933768 no 2486 0.275556285677954 3530 612214
SGTC_2124 5246320 200 µM -0.596892542240861 0.252695061851477 no 2487 0.275289563373658 3506 579342
SGTC_2455 5377712 9.75 µM -0.600329628940565 0.251631506294471 no 2488 0.274143288140504 3481 2243908
SGTC_323 4013-0906 34.3 µM -0.601865437323511 0.251157038587345 no 2489 0.273631856241324 3521 2910086
SGTC_646 4092-0839 27.3 µM -0.602281851214331 0.251028474609322 no 2490 0.273493269721684 3563 877796
SGTC_3281 9140613 49.47 µM -0.604566647835558 0.250323684691601 no 2491 0.272733486460948 3473 16013766
SGTC_906 1165-0455 526 µM -0.605618156438976 0.249999679274407 no 2492 0.272384171421383 3524 3252859
SGTC_839 0122-0028 230 µM -0.605663718174995 0.249985645192105 no 2493 0.272369040669277 3485 759448
SGTC_929 2805-0021 398 µM -0.606299942226262 0.249789716962553 no 2494 0.272157798488807 3517 3098024
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.60653016360736 0.249718839285259 no 2495 0.272081379345647 3594 94937 An inhibitor of serotonin biosynthesis.
SGTC_378 3970-0959 8.33 µM -0.60786065904452 0.249309432306331 no 2496 0.271639946922022 3523 6615653
SGTC_1115 galangin 695.678 nM -0.608087280635622 0.24923973412236 no 2497 0.271564793855675 3583 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_435 c-PAF 6.7 µM -0.608563959871949 0.249093163747058 no 2498 0.271406749577583 3481 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1255 0566-0045 221 µM -0.608882127279664 0.248995358458352 no 2499 0.271301285829282 3551 2788469
SGTC_3287 9117173 37.0625 µM -0.61059785100435 0.248468294004205 no 2500 0.270732922868529 3473 2789709
SGTC_2700 st077718 96.8 µM -0.610646650093343 0.248453311791476 no 2501 0.270716766030866 3488 904970
SGTC_165 k038-0023 64.381 µM -0.611111233178781 0.248310700401128 no 2502 0.27056297183265 3498 46368543
SGTC_2462 5162487 171.77 µM -0.612456177942174 0.247898093731011 no 2503 0.27011799154155 3520 2259986
SGTC_730 1436-0052 41.2 µM -0.613843804857925 0.247472776726304 no 2504 0.269659273710893 3549 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_586 0957-0265 8.15 µM -0.617301242237128 0.246414747259099 no 2505 0.268518023811935 3481 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1421 4029-0249 71.4 µM -0.620455580570717 0.245451589570068 no 2506 0.267478944835691 3627 2894095
SGTC_2742 clothiapine 36.27 µM -0.621369063323532 0.245173041473652 no 2507 0.267178411138439 3506 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2896 9052656 71.43 µM -0.623160198626301 0.244627364753564 no 2508 0.266589626960974 3528 6469436
SGTC_2413 inermin 26.06 µM -0.624720335552131 0.244152596121337 no 2509 0.266077312024738 3632 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2018 5133068 143 µM -0.625406624270028 0.243943907583341 no 2510 0.265852107792657 3546 785362
SGTC_1158 4092-0494 91.8 µM -0.625800055402461 0.243824315390005 no 2511 0.265723047751278 3603 1148199
SGTC_1209 2323-2347 50.3 µM -0.627239341618915 0.243387081898541 no 2512 0.265251179161794 3544 5412760
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.627354035724545 0.243352257790471 no 2513 0.265213595120298 3532 4174840
SGTC_882 0843-0131 351 µM -0.627582658236127 0.243282850094431 no 2514 0.265138686016841 3579 5425421
SGTC_2986 9022445 71.43 µM -0.628153128553955 0.243109707211591 no 2515 0.264951815948733 3545 6459286
SGTC_3096 9117468 49.47 µM -0.62932281317484 0.242754905866822 no 2516 0.26456886950302 3480 41316311
SGTC_2358 9037157 4 µM -0.631061009004164 0.242228175709066 no 2517 0.264000317124766 3557 2388925
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.631213903121655 0.242181873454307 no 2518 0.263950336278304 3553 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_879 0831-1030 162 µM -0.63163732880785 0.242053668820042 no 2519 0.263811944265383 3591 1549252
SGTC_576 1073-0113 22.7 µM -0.632606218075285 0.241760447486486 no 2520 0.263495412751882 3707 5439563
SGTC_1365 1672-3266 55.4 µM -0.632653663236111 0.241746093798143 no 2521 0.263479917623432 3570 6415873
SGTC_1764 st044502 93.5 µM -0.632958077151198 0.241654009795242 no 2522 0.263380510063352 3573 8407
SGTC_3054 9094397 49.47 µM -0.634303411110812 0.241247279732846 no 2523 0.262941415401694 3527 2598354
SGTC_419 nsc-638432 893 µM -0.634946646863848 0.241052944085964 no 2524 0.262731606254354 3534 368090
SGTC_1228 0124-0032 52.5 µM -0.638315977213591 0.240036387498363 no 2525 0.261634006793152 3590 X1228
SGTC_1068 loratadine 26.9 µM -0.640235378587329 0.239458333918147 no 2526 0.261009792759789 3557 3957 A H1 histamine antagonist.
SGTC_2749 bexarotene 57.39 µM -0.641665917932228 0.239028002609206 no 2527 0.260545061470427 3559 82146 An retinoic acid receptor inhibitor.
SGTC_1655 st012546 55.1 µM -0.642319489679877 0.238831537563668 no 2528 0.260332881155065 3553 720985 YLR208W SEC13
SGTC_2250 alverine citrate 130 µM -0.642846473826984 0.23867318936112 no 2529 0.260161862014652 3531 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_527 4476-4215 268 µM -0.643115014630856 0.238592520318988 no 2530 0.260074736287211 3531 4418754
SGTC_3155 9099265 49.47 µM -0.643953160982109 0.238340839074412 no 2531 0.259802903773752 3545 25236499
SGTC_2819 7996655 46.38 µM -0.644913273375426 0.238052712250673 no 2532 0.259491694773621 3473 6456960
SGTC_1016 4226-1401 38 µM -0.647331190074285 0.23732794928374 no 2533 0.258708809678356 3587 2901613
SGTC_432 NS 1619 61.3 µM -0.650596708275723 0.236351046759754 no 2534 0.257653427906903 3599 4552 A K+/calcium channel activator.
SGTC_1976 st070609 63.5 µM -0.651238110795761 0.236159427185678 no 2535 0.257446396203906 3551 682556
SGTC_2385 9074692 200 µM -0.65134339329859 0.236127982122218 no 2536 0.257412421410303 3558 17046906
SGTC_1524 corynanthine 62.1 µM -0.652051762896729 0.235916471075713 no 2537 0.257183890248425 3621 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2676 harmalol 100 µM -0.656911393233967 0.234468260334677 no 2538 0.2556189459849 3616 5459187 A monoamine oxidase inhibitor
SGTC_2834 9001755 58.44 µM -0.656966364819914 0.234451906521566 no 2539 0.255601272003973 3525 2989575
SGTC_1666 st014829 29 µM -0.658794086529045 0.233908526551715 no 2540 0.255014002582605 3621 3858230
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.65997803089804 0.233556913714542 no 2541 0.254633963812061 3592 521171
SGTC_111 0083-0039 52.457 µM -0.660271825512524 0.233469706754211 no 2542 0.254539703527784 3534 759313
SGTC_2936 9038235 15.59 µM -0.660305400830037 0.233459741753719 no 2543 0.254528932476059 3617 4749415
SGTC_1183 1254-0324 198 µM -0.661930637590443 0.232977661141645 no 2544 0.254007837839127 3629 5799357
SGTC_922 1866-0035 480 µM -0.662853297586143 0.23270422631733 no 2545 0.253712257496938 3612 3156169
SGTC_3299 9121982 43.1275 µM -0.663272240718058 0.232580129365645 no 2546 0.253578105893129 3614 17594604 YPL160W CDC60
SGTC_1560 lithocholic acid 53.1 µM -0.664301501308696 0.232275403939609 no 2547 0.253248680176013 3575 9903 A bile acid which acts as a detergent.
SGTC_1119 parthenolide 318.541 nM -0.664541792969335 0.232204294596532 no 2548 0.253171804705927 3676 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2570 licareol 100 µM -0.664864987178556 0.232108671068504 no 2549 0.253068425940724 3568 443158
SGTC_842 0271-0008 11.1 µM -0.66838723010177 0.231067966766683 no 2550 0.251943222364409 3668 1221709
SGTC_2981 9013952 38.96 µM -0.670233794266736 0.230523411444356 no 2551 0.251354382016515 3551 2996344
SGTC_189 3970-0742 2.116 µM -0.670399432579656 0.230474599467197 no 2552 0.251301598135597 3643 2891807
SGTC_2973 9094665 17.96 µM -0.670831203143579 0.23034738810247 no 2553 0.251164033572682 3645 25237061 YIL048W NEO1
SGTC_2308 7584454 197.62 µM -0.672367196297175 0.229895161104193 no 2554 0.250674980446192 3675 893577
SGTC_393 acivicin 6.25 µM -0.673192146447598 0.229652484631832 no 2555 0.250412528456486 3553 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1892 st058411 7.36 µM -0.673305968364452 0.229619012784617 no 2556 0.250376328264801 3601 3934738
SGTC_1132 3456-3614 2.5 µM -0.673346841233572 0.229606993882119 no 2557 0.250363329637764 3682 3125502
SGTC_2924 9010168 62.78 µM -0.674930282364385 0.229141645282487 no 2558 0.24986002999791 3664 2993929
SGTC_3210 9128157 49.47 µM -0.675420441608158 0.228997702429921 no 2559 0.249704340924025 3616 17590849
SGTC_2567 aureobasidin a 60 nM -0.675854749065926 0.228870203721743 no 2560 0.2495664350895 3704 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_33 0986-0033 35.816 µM -0.677717542104463 0.228323799718945 no 2561 0.24897540086866 3591 2848082
SGTC_2371 9071574 200 µM -0.678844922664066 0.227993467121163 no 2562 0.248618063318029 3615 45596039
SGTC_516 3992-2719 87.3 µM -0.679076580698656 0.227925622553153 no 2563 0.248544670219195 3600 5350887 YDR037W KRS1
SGTC_418 lividomycin a 100 µM -0.679172282613587 0.227897598111891 no 2564 0.248514353638583 3653 72394 An antibiotic.
SGTC_3340 9146634 11.102 µM -0.680829834590945 0.227412523987756 no 2565 0.247989584848441 3649 4907387
SGTC_259 usnic acid 108.925 µM -0.681863386494893 0.227110354931664 no 2566 0.247662669442341 3722 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2174 5790901 200 µM -0.683848837550229 0.226530524320332 no 2567 0.247035311948676 3660 786020
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.684063943290018 0.226467755113271 no 2568 0.246967394497532 3696 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_799 1310-0557 151 µM -0.68549826335432 0.226049462659352 no 2569 0.246514778067194 3668 5354492
SGTC_2130 NSC 7 2.4545 µM -0.685725866136243 0.225983126761888 no 2570 0.246442996232954 3661 21448
SGTC_912 3474-0017 2.18 µM -0.686143782162203 0.225861351838201 no 2571 0.246311222186182 3689 3360550
SGTC_636 0kpi-0074 126 µM -0.686787308438831 0.225673909808374 no 2572 0.246108384345519 3640 616434
SGTC_1686 st019653 115.5 µM -0.687380880928088 0.225501096039289 no 2573 0.245921371271743 3657 97252
SGTC_1960 st011366 51.8 µM -0.688796850333876 0.225089150758219 no 2574 0.245475559000353 3671 3972846
SGTC_964 1287-0107 19.4 µM -0.690635200440893 0.22455495976628 no 2575 0.2448974103232 3668 51516812 YPR165W RHO1
SGTC_1299 1079-1439 3.74 µM -0.691065833339282 0.22442992976383 no 2576 0.244762085196668 3630 323161
SGTC_402 epigallocatechin gallate 10 µM -0.691823848436773 0.224209943587135 no 2577 0.244523979001276 3635 65064 An antioxidant.
SGTC_2707 st078556 66.6 µM -0.692174732215767 0.224108153867266 no 2578 0.244413802348732 3649 17250899
SGTC_674 0498-0004 451 µM -0.693819153679265 0.223631464898663 no 2579 0.243897814645535 3639 4231473
SGTC_269 exalamide 29 µM -0.694252453878177 0.223505954810564 no 2580 0.243761951322586 3638 3316 A derivative of salicylamide.
SGTC_3195 9113082 49.47 µM -0.695619320276644 0.223110289850955 no 2581 0.243333631750151 3636 17018038
SGTC_808 0711-0032 135 µM -0.695687254479769 0.223090635438295 no 2582 0.243312354586804 3641 4252555
SGTC_2252 omeprazole 400 µM -0.696527534359942 0.222847611038648 no 2583 0.243049259970216 3604 4594 A proton pump inhibitor.
SGTC_1966 st070145 16.1 µM -0.697919169280734 0.222445456572442 no 2584 0.242613872765425 3626 3748532
SGTC_3236 9132701 49.47 µM -0.698287529920553 0.222339077086077 no 2585 0.242498698103175 3657 24282524
SGTC_1556 plumbagin 1.48 µM -0.69891145963436 0.22215895760511 no 2586 0.242303682698196 3598 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1609 st001574 46.4 µM -0.698995426920477 0.222134723823949 no 2587 0.242277444382314 3675 3960012
SGTC_266 formosanin C 406 nM -0.700120311944884 0.221810216521158 no 2588 0.241926085927051 3652 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_772 k072-0172 35.3 µM -0.701211402473039 0.221495717137032 no 2589 0.241585547464095 3645 5861980
SGTC_716 1683-5115 658 µM -0.706399875010762 0.220003668240708 no 2590 0.239969749294403 3704 723597
SGTC_261 5-fluorouridine 15.376 µM -0.708385253574474 0.219434262023444 no 2591 0.239353023719402 3719 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.710680970954598 0.218776907481895 no 2592 0.238640977092397 3712 165521
SGTC_899 1083-0020 478 µM -0.710865888988105 0.218724007507444 no 2593 0.23858367284787 3722 767123
SGTC_110 0850-0284 111.64 µM -0.711309281070451 0.218597195193706 no 2594 0.238446300772063 3552 3906265
SGTC_2347 9049783 174.81 µM -0.712271874678072 0.2183220344362 no 2595 0.238148218404218 3681 6467988 YPL169C MEX67
SGTC_1208 2323-2347 50.3 µM -0.712907034491375 0.218140581097484 no 2596 0.237951642972347 3682 5412760
SGTC_2667 digitoxin 100 µM -0.714071295742305 0.217808199106345 no 2597 0.23759154717846 3665 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2363 9053361 176 µM -0.714641948340866 0.217645391682697 no 2598 0.237415158601661 3728 6469797 YMR079W SEC14
SGTC_3269 9137823 49.47 µM -0.715733556159058 0.217334151239955 no 2599 0.237077943290115 3641 17682936
SGTC_855 0428-0020 25 µM -0.716040503408037 0.217246680415356 no 2600 0.236983169750665 3720 6812414
SGTC_192 3455-0609 60.9 µM -0.716275827250294 0.217179633900976 no 2601 0.236910524877073 3745 3769639
SGTC_2971 9092186 9.93 µM -0.716827420473705 0.217022525396034 no 2602 0.23674029509114 3698 25236400
SGTC_27 0485-0001 32.618 µM -0.718219870821834 0.216626210596661 no 2603 0.236310863844433 3633 2054479
SGTC_244 nsc-207895 1.295 µM -0.718970376219814 0.216412777875089 no 2604 0.236079586220702 3581 42640
SGTC_1689 st020265 53.493 µM -0.719308928954688 0.21631653829197 no 2605 0.235975297791872 3706 5758320 YPR016C TIF6
SGTC_2691 st077356 60.2 µM -0.719372601092964 0.21629844113249 no 2606 0.235955686942043 3766 2839272
SGTC_2708 st078559 56 µM -0.722425528568622 0.215431754435081 no 2607 0.235016448116868 3640 17250902
SGTC_270 tamoxifen 5.46 µM -0.726536680629582 0.214267840347917 no 2608 0.233754914682048 3776 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1418 3966-3099 2.4 µM -0.727879474843676 0.213888473952899 no 2609 0.233343684301735 3712 740335
SGTC_758 0868-0029 16 µM -0.727997604187724 0.213855118761244 no 2610 0.233307526441169 3751 762687
SGTC_2324 6149169 200 µM -0.728317748586592 0.213764737502475 no 2611 0.233209550024407 3663 2888231
SGTC_2151 5563267 85.4165 µM -0.728379481173954 0.213747312085163 no 2612 0.233190660121076 3748 5310824
SGTC_2290 7904846 200 µM -0.729300782218472 0.213487352377992 no 2613 0.232908846951741 3784 2962154
SGTC_1420 4'-methoxyflavone 42 µM -0.732374822713391 0.212621297276946 no 2614 0.231969910844036 3712 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1781 st038725 66.3 µM -0.732512266575177 0.212582622943592 no 2615 0.231927979221816 3745 4270275 YIL048W NEO1
SGTC_1961 st076550 68.7 µM -0.732853642329166 0.212486583468237 no 2616 0.231823849952951 3712 1579337
SGTC_1050 3232-1156 69.3 µM -0.735128370506403 0.211847280087374 no 2617 0.231130658789483 3709 700529
SGTC_1922 5578187 25 µM -0.735136446504882 0.211845012366456 no 2618 0.231128199805745 3741 1350412
SGTC_1500 4488-1866 171 µM -0.735219260365588 0.21182175925339 no 2619 0.231102985445687 3806 2900003
SGTC_2276 7947513 42.08 µM -0.735376376888534 0.211777646971626 no 2620 0.231055152351846 3620 2105100
SGTC_2746 daunorubicin 9.88 µM -0.736690583207104 0.211408878927597 no 2621 0.230655267356427 3616 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3083 9117465 49.47 µM -0.736816964950586 0.211373435874734 no 2622 0.230616832474089 3701 16420915
SGTC_1066 ketoconazole 628 nM -0.736980365369408 0.211327616300707 no 2623 0.230567144874808 3776 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1048 3161-0300 24.5 µM -0.738632226266643 0.210864740118364 no 2624 0.230065175004888 3733 2165101
SGTC_492 tmb-8 126 µM -0.738854190640821 0.210802587717766 no 2625 0.229997770787117 3628 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1876 myriocin 605 nM -0.739140747486873 0.210722364625021 no 2626 0.229910768033614 3753 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2863 9028737 58.44 µM -0.741524915009506 0.210055599096713 no 2627 0.229187615404952 3740 6460917
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.74241667057963 0.209806526150817 no 2628 0.228917461127515 3740 688798
SGTC_3270 9137563 49.47 µM -0.74528146612953 0.209007546406282 no 2629 0.228050791491844 3736 17015724
SGTC_1796 st049173 110.4 µM -0.745704374639751 0.208889750940122 no 2630 0.227923007984376 3692 94134
SGTC_628 1636-0253 16 µM -0.745858346594816 0.208846873840986 no 2631 0.227876494743443 3758 4456143
SGTC_2851 9015922 71.43 µM -0.746269185216062 0.208732491579635 no 2632 0.22775241103814 3744 2996893
SGTC_2671 danthron 100 µM -0.749104990363239 0.207943977853897 no 2633 0.226896963723806 3735 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2054 5233173 129 µM -0.749505211181218 0.20783283569291 no 2634 0.226776379454774 3779 6889
SGTC_1034 k072-0165 12.7 µM -0.749618002387295 0.207801519676126 no 2635 0.226742402634309 3738 5835461
SGTC_1562 morin hydrate 59.1 µM -0.74962603043779 0.207799290827006 no 2636 0.226739984402529 3792 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_936 3005-4620 401 µM -0.752241178868938 0.207073991887085 no 2637 0.225953016990634 3769 777207
SGTC_205 1486-1330 71.903 µM -0.752617387844047 0.2069697754892 no 2638 0.225839932943197 3738 4118834
SGTC_2076 5212012 200 µM -0.757248030754075 0.205689551385544 no 2639 0.224450639782009 3669 604802
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.758691700817568 0.205291386039071 no 2640 0.224018501308857 3742 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2612 dictamnine 15.46 µM -0.758813636668421 0.20525777701729 no 2641 0.223982023512586 3747 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_592 k241-0073 46.5 µM -0.760166050811944 0.204885232082292 no 2642 0.223577667563542 3767 4230158
SGTC_727 3032-0951 202 µM -0.762322770058839 0.204291960468807 no 2643 0.222933693572995 3772 3652836
SGTC_699 0375-0592 111 µM -0.763307941020075 0.204021299735041 no 2644 0.222639883658946 3792 762578
SGTC_659 k018-0002 107 µM -0.763388204932014 0.203999257862299 no 2645 0.222615956087024 3746 6797879 YHR007C ERG11
SGTC_895 0964-0006 13.7 µM -0.764007983595699 0.203829103593837 no 2646 0.222431242491944 3739 6738897
SGTC_1813 st051246 8.6015 µM -0.764231481459159 0.203767765164706 no 2647 0.222364654528133 3702 5291959
SGTC_493 zm226600 134 µM -0.764701546349667 0.203638792946842 no 2648 0.222224642590523 3778 5240098 A potassium channel opener. YCR052W RSC6
SGTC_10 0279-0212 42.575 µM -0.764744338299071 0.20362705449073 no 2649 0.222211899223989 3782 39851 YBR002C RER2
SGTC_230 MPP+ 141.667 µM -0.765348933725114 0.203461248271087 no 2650 0.222031896353145 3773 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2379 9035213 200 µM -0.76596398298653 0.203292657825254 no 2651 0.221848866564582 3767 646551
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.766049368589516 0.203269259467749 no 2652 0.221823463854709 3762 61125 An anti-inflammatory.
SGTC_25 0118-0223 35.662 µM -0.767674771973578 0.202824154077827 no 2653 0.221340213909679 3794 5333628
SGTC_133 0724-0033 378.92 µM -0.767773732547223 0.202797073232177 no 2654 0.221310811320797 3653 280309
SGTC_2255 7941087 197.44 µM -0.768172466642632 0.202687980389434 no 2655 0.221192364405218 3781 935561
SGTC_2976 9009005 19.48 µM -0.768182458328153 0.202685247134958 no 2656 0.221189396766895 3766 2993148
SGTC_2129 girgensonine 121.053 µM -0.768398082297593 0.202626267941185 no 2657 0.221125359673188 3841 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1878 temozolomide 1 mM -0.769519530341851 0.202319685941257 no 2658 0.220792477481608 3704 5394 DNA alkylating agent.
SGTC_541 4513-1321 94 µM -0.770266762831079 0.20211556127249 no 2659 0.220570834012469 3792 747515
SGTC_2147 5545932 89.7195 µM -0.770382057243207 0.202084076786473 no 2660 0.220536646837236 3815 797404
SGTC_3164 9100705 49.47 µM -0.772510697828754 0.201503317147458 no 2661 0.219906006654915 3788 17174235
SGTC_121 0557-0495 61.343 µM -0.772820365509354 0.201418913537186 no 2662 0.219814349487294 3917 3104427
SGTC_3278 9139605 49.47 µM -0.773497640429047 0.201234388063146 no 2663 0.219613962323773 3799 7958859
SGTC_1006 4099-6547 255 µM -0.775045768270693 0.200812977049828 no 2664 0.219156307735043 3828 3146833
SGTC_1765 st044815 90.4 µM -0.775805678905929 0.20060631809603 no 2665 0.21893186518515 3827 645695
SGTC_2387 9077560 195.08 µM -0.777461756238869 0.200156387729859 no 2666 0.218443194660678 3781 5303272
SGTC_654 1124-0271 80.9 µM -0.77872035431213 0.199814852247671 no 2667 0.218072231657466 3802 5403748
SGTC_529 4076-0302 30.3 µM -0.779443497264563 0.199618777509371 no 2668 0.217859254683055 3773 5816522
SGTC_694 1315-0438 43.2 µM -0.779600736846262 0.19957615851657 no 2669 0.217812961035901 3762 6793154
SGTC_656 4090-1979 187 µM -0.780617597053809 0.199300675942148 no 2670 0.21751371945063 3804 22330961
SGTC_2373 9071805 200 µM -0.780662697343429 0.19928846290764 no 2671 0.217500452837141 3776 10149009
SGTC_652 0437-0092 114 µM -0.782082162227707 0.198904306074171 no 2672 0.217083144554905 3761 3091274
SGTC_1202 1988-0068 29.6 µM -0.782265435958337 0.19885473834832 no 2673 0.217029297679853 3772 2850480
SGTC_391 gliotoxin 8.33 µM -0.782425017929479 0.198811584297661 no 2674 0.216982417866908 3903 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1396 3511-0007 98.6 µM -0.782573810701789 0.198771352941423 no 2675 0.216938712830382 3794 X1396
SGTC_2820 7989630 71.43 µM -0.78364319204493 0.198482352536089 no 2676 0.216624752210967 3706 2984098
SGTC_2336 9001819 198.65 µM -0.784761068537773 0.198180517469413 no 2677 0.216296835012681 3826 2989602
SGTC_639 0833-0042 114 µM -0.784782920543999 0.198174620025899 no 2678 0.216290427823557 3784 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2097 5376186 200 µM -0.785001832335505 0.198115545717718 no 2679 0.216226247138161 3749 742755
SGTC_1201 1889-3372 45.9 µM -0.785067564803868 0.198097809598322 no 2680 0.216206977807975 3711 5392199
SGTC_734 2023-0417 80 µM -0.787352394410998 0.197481906458983 no 2681 0.215537803184251 3802 3935732
SGTC_2073 5212005 126 µM -0.787892240893971 0.197336553661944 no 2682 0.215379870038883 3650 691789
SGTC_1744 st037937 38.9 µM -0.788071934242267 0.19728818587466 no 2683 0.215327315295437 3860 1016152
SGTC_225 nsc-122657 1.016 µM -0.788192457847269 0.19725574873615 no 2684 0.215292070040333 3820 275685
SGTC_141 0443-0274 32.331 µM -0.788828460281694 0.197084631564758 no 2685 0.215106136466604 3861 1627241
SGTC_3153 9100258 49.47 µM -0.789643131903731 0.196865574527805 no 2686 0.214868105685006 3749 25236848
SGTC_2289 7946404 165.07 µM -0.789652106647882 0.196863162130273 no 2687 0.214865484296314 3838 1246120 YPR165W RHO1
SGTC_1341 1486-1360 280 µM -0.789791061200266 0.196825813642589 no 2688 0.214824900117964 3778 3976547
SGTC_1393 3470-5649 58.2 µM -0.789872321672497 0.196803974275663 no 2689 0.214801168598063 3782 4108395
SGTC_182 3448-4371 550.524 µM -0.790765344908093 0.196564064208731 no 2690 0.21454046812763 3788 3491403
SGTC_1211 1056-0033 32.3 µM -0.790894264427082 0.196529444712607 no 2691 0.214502847823714 3804 6741922
SGTC_973 1325-0077 65.9 µM -0.792592795049611 0.19607367363459 no 2692 0.21400755392057 3847 2835149
SGTC_2065 5221596 34.26 µM -0.793711386650533 0.195773869506035 no 2693 0.213681734924092 3815 788581
SGTC_1975 st070967 30.8 µM -0.796968511239233 0.194902483143385 no 2694 0.212734659680878 3784 261391
SGTC_224 benfluorex 43.875 µM -0.797600798529271 0.194733599582772 no 2695 0.212551093747306 3794 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2050 5263056 171 µM -0.797666063533383 0.194716172409017 no 2696 0.212532151250818 3862 763468 YGL055W OLE1
SGTC_2024 5144227 134 µM -0.797778338956746 0.194686194652333 no 2697 0.212499566770825 3887 3475211
SGTC_2089 5281248 129.67 µM -0.799722537921586 0.194167535146412 no 2698 0.211935785924139 3823 2737878
SGTC_2710 st078562 53.7235 µM -0.800016549039521 0.194089174286642 no 2699 0.211850604498176 3801 17250908
SGTC_2791 5663188 71.43 µM -0.801113834445828 0.193796892149604 no 2700 0.211532873936934 3823 54690634
SGTC_1237 0330-0133 46.1 µM -0.801173362263079 0.193781043497935 no 2701 0.211515645011988 3772 X1237 YHR072W ERG7
SGTC_2060 5238662 140 µM -0.801705398561029 0.193639429552733 no 2702 0.211361696125934 3825 790130
SGTC_2453 5731132 22.18 µM -0.802027842515108 0.193553634250134 no 2703 0.211268426382493 3859 1362040
SGTC_1150 3909-7983 10.9 µM -0.802649956751781 0.1933881687542 no 2704 0.211088542536557 3823 23965914
SGTC_1249 0481-0015 10.2 µM -0.803159209809703 0.19325278552911 no 2705 0.21094135925288 3781 4227577
SGTC_2827 7993847 71.43 µM -0.804269414264236 0.192957841957157 no 2706 0.210620698868157 3890 2985692
SGTC_2933 9026794 32.47 µM -0.805269637475192 0.192692352209099 no 2707 0.210332049433695 3846 17586027
SGTC_2396 5342950 42.78 µM -0.805553651786635 0.192617006857277 no 2708 0.210250129517665 3850 1886677
SGTC_1939 st074455 53.6 µM -0.806211615737532 0.192442526652738 no 2709 0.210060421110395 3818 1644229
SGTC_1720 st037298 9.481 µM -0.806557573373553 0.192350823686178 no 2710 0.209960712729338 3861 597396
SGTC_7 0192-1582 4.227 µM -0.806697170446651 0.192313828267943 no 2711 0.209920487361726 3885 252616
SGTC_3233 9132340 49.47 µM -0.807917874289 0.191990508001003 no 2712 0.209568930446662 3850 17682950
SGTC_672 1441-0018 53.7 µM -0.808556027536145 0.191821616796676 no 2713 0.209385283264194 3836 251141
SGTC_3021 9087658 49.47 µM -0.809055161406309 0.19168958134729 no 2714 0.209241708980878 3786 25237042
SGTC_2866 9034245 58.44 µM -0.810018929964972 0.191434794025765 no 2715 0.208964648030153 3817 6462273
SGTC_1248 0469-0687 58.6 µM -0.812988145267898 0.190651140797734 no 2716 0.208112427497312 3853 4017482
SGTC_2474 5321570 43.32 µM -0.813539738884499 0.190505778050852 no 2717 0.207954336007308 3868 2841384
SGTC_2960 9079389 5.97 µM -0.8137315939509 0.190455233994826 no 2718 0.207899365314129 3844 16457355
SGTC_42 0133-0086 60.653 µM -0.814159481186528 0.190342537128395 no 2719 0.20777679712907 3761 162923 Model of phenazepam hydroxylation.
SGTC_3107 9121808 49.47 µM -0.814880669371343 0.190152683427504 no 2720 0.207570309584959 3752 662681
SGTC_3045 9092950 49.47 µM -0.815090415650822 0.1900974893036 no 2721 0.207510278689366 3812 44120432
SGTC_2831 7999036 19.48 µM -0.815215974258682 0.190064453632197 no 2722 0.207474347821851 3924 2988270
SGTC_515 4092-1064 102 µM -0.821860685299296 0.188321203841844 no 2723 0.205578095327605 3862 717353
SGTC_3039 9090270 49.47 µM -0.821942352062653 0.188299839989339 no 2724 0.205554853640613 3821 17173750
SGTC_2641 levomentholum 100 µM -0.824357366846216 0.187668753254075 no 2725 0.20486826575935 3822 16666
SGTC_1506 4226-2149 212 µM -0.825566800389315 0.187353198167608 no 2726 0.204524937295189 3902 991114
SGTC_687 k029-0044 34.9 µM -0.825814246984713 0.187288676954872 no 2727 0.204454735503869 3916 5829338
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.826377327051588 0.187141906144056 no 2728 0.204295040436057 3874 688662
SGTC_379 3970-0972 5.9 µM -0.827349921332819 0.186888560158098 no 2729 0.204019378086423 3867 2898042 YBL034C STU1
SGTC_2189 6047310 154.431 µM -0.827886078378769 0.186748990210436 no 2730 0.203867509922707 3818 711535
SGTC_2313 7726885 200 µM -0.82948474803932 0.186333214980971 no 2731 0.20341508185839 3903 726423
SGTC_532 1548-0774 215 µM -0.829653561856647 0.18628934410097 no 2732 0.203367342059418 4012 5932993
SGTC_2523 spermine 47.74 µM -0.830747878119613 0.186005111374926 no 2733 0.203058036435147 3887 1103 A DNA binding polyamine.
SGTC_859 0439-0102 54.6 µM -0.835513191496323 0.18477052785122 no 2734 0.201714411368846 3852 610143
SGTC_511 blebbistatin 171 µM -0.836435677695432 0.184532122615788 no 2735 0.201454924203049 3956 3476986 A myosin inhibitor.
SGTC_345 1362-0200 395 µM -0.837933622706834 0.184145404880909 no 2736 0.201033991982265 3885 1419823
SGTC_1792 st045773 43.6 µM -0.838445768137694 0.184013302398784 no 2737 0.200890196919574 3802 2919270
SGTC_327 1273-0057 3.96 µM -0.840693557816353 0.18343420695024 no 2738 0.200259815261459 3788 3108138
SGTC_967 1306-0166 352 µM -0.840984117947109 0.183359433287611 no 2739 0.200178415931985 3834 4437607
SGTC_294 k038-0071 157 µM -0.841949997583295 0.183111007381805 no 2740 0.199907971330464 3894 24152826
SGTC_1001 4048-4355 44.4 µM -0.843916296804034 0.182605921008836 no 2741 0.199358090401661 3876 21824233
SGTC_900 1112-0045 141 µM -0.84408829322779 0.182561781435569 no 2742 0.199310034487375 3806 56211 YIL048W NEO1
SGTC_650 1328-0195 38 µM -0.84414149663354 0.182548129154531 no 2743 0.199295170833421 3822 2780821
SGTC_2158 5657123 3.6195 µM -0.845437071561524 0.18221587447682 no 2744 0.198933426820536 3839 2858827
SGTC_1124 fisetin 1.16336 µM -0.845694268478637 0.18214996042798 no 2745 0.198861660677398 3922 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1263 0774-1208 64.8 µM -0.847377047341345 0.181719068175861 no 2746 0.198392496899472 3900 906585
SGTC_2466 5983409 37.09 µM -0.84848610950959 0.181435430743724 no 2747 0.198083652522617 3912 2879657
SGTC_2743 auranofin 4.32 µM -0.848527905227405 0.181424747107478 no 2748 0.198072019203882 3848 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1987 st072290 61.9 µM -0.848960476675261 0.181314198242376 no 2749 0.197951642548264 3925 54697379
SGTC_1608 st001473 40.5 µM -0.851434711926929 0.180682688423449 no 2750 0.197263958115467 3870 7292267
SGTC_1360 1598-0022 39.8 µM -0.851614254194108 0.180636916802281 no 2751 0.19721411276878 3965 761525
SGTC_1610 st001799 48.1 µM -0.852421362161955 0.180431246495684 no 2752 0.196990133894735 3813 621897
SGTC_1009 4106-0057 9.87 µM -0.853551226240815 0.180143577141006 no 2753 0.19667684640594 3853 2928005
SGTC_3103 9120822 49.47 µM -0.853590094393111 0.180133686229526 no 2754 0.196666074459111 3909 17141819
SGTC_65 0798-0905 34.986 µM -0.853821029500044 0.180074926414243 no 2755 0.196602080312394 3953 3602145
SGTC_2953 9074162 66.49 µM -0.854472023684228 0.179909350301881 no 2756 0.196421752021849 3870 16451992
SGTC_725 1497-0963 19 µM -0.854560329206489 0.179886897736861 no 2757 0.196397298722141 3970 3549977
SGTC_2619 obliquin 87.91 µM -0.859545273197683 0.178622280437337 no 2758 0.195019876761159 3879 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3014 9081533 49.47 µM -0.859912820221631 0.178529260536776 no 2759 0.194918550490259 3964 21367265
SGTC_2941 9056145 11.23 µM -0.860463103581641 0.178390050224898 no 2760 0.194766906873065 3777 2119517
SGTC_2644 guaiazulene 100 µM -0.860589129525243 0.178358177894565 no 2761 0.194732187540879 3922 3515 A coloring agent.
SGTC_2873 9040596 71.43 µM -0.861623313443361 0.178096765297315 no 2762 0.194447418803604 3905 6463863
SGTC_1919 st067113 52.3 µM -0.86252833866385 0.177868198666478 no 2763 0.194198422785608 3981 1268243
SGTC_2223 6903751 107.57 µM -0.862535631671227 0.177866357549013 no 2764 0.194196417078342 3871 5598863
SGTC_1615 st002656 86.5 µM -0.863589795627688 0.177600360626206 no 2765 0.193906635893093 3910 1584458
SGTC_1101 ebselen 5.29 µM -0.865197364145724 0.177195206861716 no 2766 0.193465235939682 3977 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3292 9120825 59.784 µM -0.867590589530114 0.176593127231169 no 2767 0.192809249961445 3896 24824900
SGTC_976 1348-1067 47.6 µM -0.868282859646998 0.176419209753095 no 2768 0.192619751556995 3965 5310671 YGL099W LSG1
SGTC_3144 9087057 49.47 µM -0.868799247351217 0.176289549405705 no 2769 0.192478472433703 3773 17249618
SGTC_425 3825-7017 13.1 µM -0.870796241740694 0.175788689637839 no 2770 0.191932708846193 4027 3397440
SGTC_3341 9147222 25.867 µM -0.871752228042744 0.17554924113193 no 2771 0.191671780549053 3950 1939759
SGTC_1773 st048542 73.5835 µM -0.87437490388223 0.174893394372542 no 2772 0.190957059881294 3873 3237138
SGTC_593 1203-0218 61.7 µM -0.875801285984002 0.174537355821073 no 2773 0.190569035421388 3984 3666956
SGTC_3133 9127736 49.47 µM -0.87619871617853 0.174438235514233 no 2774 0.190461007170875 3879 27243420
SGTC_1634 st006576 41 µM -0.876511180758932 0.174360331004015 no 2775 0.190376100421505 3922 3915356
SGTC_1927 st060202 13.8 µM -0.877221946953991 0.174183203204922 no 2776 0.190183048821122 3829 688887
SGTC_1637 st007924 17.4 µM -0.877472255713357 0.174120851787461 no 2777 0.190115090968992 3891 683336
SGTC_663 1486-0733 13.9 µM -0.880241496997819 0.173431986172738 no 2778 0.18936424889153 3945 722445 YPR165W RHO1
SGTC_1377 2944-0135 198 µM -0.88074580364253 0.173306723802728 no 2779 0.189227709734881 4003 1894137
SGTC_3277 9138724 49.47 µM -0.883085760949417 0.172726266700747 no 2780 0.188594968431081 3886 15943418
SGTC_1958 st076513 41.9 µM -0.88725829724223 0.171694293489851 no 2781 0.18746992614359 3928 732122 YGL099W LSG1
SGTC_846 0335-0850 148 µM -0.88764014707187 0.171600049531981 no 2782 0.187367175427794 3940 6819598
SGTC_547 1120-0019 610 nM -0.887980351622461 0.171516111848907 no 2783 0.187275660234772 3882 3676939
SGTC_3073 9114972 49.47 µM -0.888073284894129 0.171493187255329 no 2784 0.187250665945281 3926 41905075
SGTC_557 1315-0110 16.2 µM -0.888487581738409 0.171391013162111 no 2785 0.18713926641252 3932 6833801
SGTC_773 4358-1457 44.6 µM -0.889128177204338 0.171233105803392 no 2786 0.186967098558018 3921 1186886
SGTC_115 0527-0192 112.043 µM -0.889138980949404 0.171230443468409 no 2787 0.186964195760175 3974 4233931
SGTC_2764 methyldopa 94.69 µM -0.8893548787361 0.171177245963918 no 2788 0.186906193237661 3942 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_543 3844-1095 191 µM -0.890175051134184 0.170975250732944 no 2789 0.186685949424517 3958 4230703
SGTC_627 1391-0720 175 µM -0.890186740614266 0.170972372905161 no 2790 0.186682811568555 3935 997839
SGTC_3261 9137475 49.47 µM -0.891078687959165 0.170752876189841 no 2791 0.186443478722471 3860 17027690
SGTC_3262 9137218 49.47 µM -0.891259087928591 0.17070850402574 no 2792 0.186395095799937 3766 17650664
SGTC_559 1550-0661 158 µM -0.891994297903892 0.170527744095785 no 2793 0.186197994359652 4008 5830875
SGTC_3335 9143315 29.6265 µM -0.892080696057145 0.170506510154555 no 2794 0.186174840480791 3960 4899691
SGTC_1805 st050013 60.3 µM -0.89359661043692 0.17013422169633 no 2795 0.185768880289456 3901 4037144
SGTC_2519 cryptotanshinone 88.04 µM -0.894767461624809 0.169847032998934 no 2796 0.185455703775835 3947 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2309 7664088 163.95 µM -0.899924126429363 0.168585897908168 no 2797 0.184080314874069 3984 704922
SGTC_570 0987-0065 62.6 µM -0.900272009455112 0.168501035506517 no 2798 0.18398775650243 3767 3104428
SGTC_3179 9107801 49.47 µM -0.902185708078284 0.168034700091113 no 2799 0.183479112782478 3975 4818259
SGTC_2551 apiole 73.87 µM -0.904969483799473 0.167357826229574 no 2800 0.182740777059844 3803 10659 A possible DNA adduct former.
SGTC_835 0312-0010 67.2 µM -0.905391701565587 0.167255317834938 no 2801 0.182628955238108 3927 1626196
SGTC_2748 diazoxide 86.69 µM -0.906748611127561 0.166926153824636 no 2802 0.182269875347227 3979 3019 A potassium channel activatior.
SGTC_186 3455-3465 67.277 µM -0.90694098158017 0.166879521747183 no 2803 0.182219003957487 3928 755278
SGTC_1955 wogonin 32.4 µM -0.908914988708868 0.166401492835032 no 2804 0.181697500629258 4069 5281703 A flavanone.
SGTC_122 0236-0016 402.397 µM -0.909068313803905 0.166364400409716 no 2805 0.181657033540238 3989 6808838
SGTC_1140 3229-1848 2.98 µM -0.910054900508158 0.166125852954313 no 2806 0.181396778645913 4015 2849525
SGTC_3342 9147791 14.508 µM -0.910915947071463 0.165917840611201 no 2807 0.18116983126431 3896 1838168
SGTC_1695 st026914 34.495 µM -0.911301647610916 0.165824717369765 no 2808 0.181068229275557 3948 3289191
SGTC_759 3486-0358 89.3 µM -0.914141286313627 0.165140157476661 no 2809 0.180321305396092 3949 875103
SGTC_2215 7188065 200 µM -0.916823162180866 0.164495312052098 no 2810 0.17961765661165 4000 940217
SGTC_852 0418-0143 439 µM -0.917579516105334 0.164313745469088 no 2811 0.179419522975034 4011 5369229
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.919461018104945 0.163862645299081 no 2812 0.178927243114989 4055 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_910 3454-3003 490 µM -0.920378860173294 0.163642879690533 no 2813 0.178687405893084 3932 820824
SGTC_2369 9071472 200 µM -0.923702629079012 0.162848647505412 no 2814 0.177820581456439 4066 17296037
SGTC_3012 9080433 71.4286 µM -0.925440574060226 0.162434356039333 no 2815 0.177368390855583 3981 17688859
SGTC_2829 7992743 58.44 µM -0.926176014222593 0.162259248481803 no 2816 0.177177257736248 4032 16462845
SGTC_504 lovastatin 124 µM -0.92665824835636 0.16214449575953 no 2817 0.177052000831564 4020 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2273 7815444 169.05 µM -0.927382795931503 0.161972181361155 no 2818 0.176863909929938 3960 2824616
SGTC_194 1486-1323 56.904 µM -0.927865671939397 0.161857408391692 no 2819 0.176738626574673 4048 5178754
SGTC_3310 9130229 44.1445 µM -0.928448834048123 0.161718869456058 no 2820 0.176587398559979 4074 7761258
SGTC_416 estradiol valerate 100 µM -0.92857605645357 0.161688656130957 no 2821 0.176554417595368 4028 13791 A steroid.
SGTC_394 menadione 8.33 µM -0.928710958643477 0.161656622996651 no 2822 0.176519449989675 3998 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1405 3909-7894 12 µM -0.932602351813075 0.160734374959458 no 2823 0.1755126593248 4011 7104060
SGTC_292 k038-0015 474 µM -0.933048479168645 0.160628864121178 no 2824 0.175397469168055 4012 46368540
SGTC_848 0368-0089 85.6 µM -0.933438283154086 0.16053671101582 no 2825 0.175296860957209 4022 762535
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.933902034393553 0.160427121121071 no 2826 0.175177214671659 4003 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1129 3453-1384 223 µM -0.934143626328225 0.160370049463716 no 2827 0.175114905276148 4133 1084452
SGTC_3003 9075612 71.4286 µM -0.934238199435317 0.160347711917982 no 2828 0.175090517591159 4036 6501993
SGTC_874 0599-0792 117 µM -0.935752921523273 0.159990221615242 no 2829 0.174700207953616 4031 765305
SGTC_2341 7987486 176.74 µM -0.936566131685329 0.159798510679492 no 2830 0.174490890145119 4042 1258686
SGTC_1490 4089-0339 670 nM -0.936842256090267 0.159733449683996 no 2831 0.174419852808999 3951 742542
SGTC_3119 9125183 49.47 µM -0.938507388518042 0.159341475232171 no 2832 0.173991860873931 3824 22695334
SGTC_2602 kawain 100 µM -0.939697531956156 0.159061700128432 no 2833 0.173686365737185 4014 5369129
SGTC_2015 5119600 184 µM -0.940066697124761 0.158974983400844 no 2834 0.173591674976934 4070 2828786
SGTC_1448 4255-0083 152 µM -0.940115841680339 0.158963441704352 no 2835 0.173579071890509 4099 5399660
SGTC_1978 st071761 42 µM -0.940758984346779 0.158812448984814 no 2836 0.173414192081734 4043 5147680
SGTC_2357 9067248 200 µM -0.940967561126784 0.158763500922485 no 2837 0.173360741536381 4020 9150235
SGTC_1645 Cervolide 78 µM -0.941296239963545 0.158686387806994 no 2838 0.173276534546493 4001 23173 A fragrance.
SGTC_3040 9091894 49.47 µM -0.942117339402022 0.158493852556782 no 2839 0.173066284011039 3895 25236966
SGTC_1210 3013-0140 750 nM -0.942663900695436 0.158365777273605 no 2840 0.172926421778804 4053 905973
SGTC_2741 miltefosine 3.04 µM -0.943789303410678 0.15810227642656 no 2841 0.172638663888117 3988 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2970 9090938 41.86 µM -0.944793262697941 0.157867453257002 no 2842 0.172382216072118 4107 17217104
SGTC_51 1013-0126 23.419 µM -0.946270653294715 0.15752231259912 no 2843 0.172005278789041 4004 1627850
SGTC_568 1193-0097 7.48 µM -0.948831836120056 0.156925157563947 no 2844 0.171353073593097 3892 3646150
SGTC_992 3909-8734 162 µM -0.949368714367783 0.156800170269461 no 2845 0.171216558232328 4040 4288319
SGTC_745 0469-0705 296 µM -0.951063362169291 0.156406079683274 no 2846 0.170786105979396 4120 3486736
SGTC_3020 9089140 49.47 µM -0.953298139569316 0.155887380028242 no 2847 0.170219516929632 4076 17217859
SGTC_1204 4049-0315 18.3 µM -0.955311218208148 0.155421109381193 no 2848 0.169710168035444 4136 588402
SGTC_2738 aclarubicin 5.55 µM -0.955634837990987 0.155346238294391 no 2849 0.169628377099524 3993 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2581 avocatin a 64 µM -0.956079782956688 0.155243336874342 no 2850 0.169515964000613 4019 6710728 A skin care supplement.
SGTC_2127 5253358 187.912 µM -0.956453200671431 0.155157012132051 no 2851 0.169421658800137 3944 20612
SGTC_1851 st056236 18.9 µM -0.957430091220829 0.154931329633791 no 2852 0.169175108156039 4030 5393171
SGTC_155 k072-0202 43.6 µM -0.958830067469372 0.154608283511079 no 2853 0.168822179691713 3938 5857737
SGTC_2506 ethyl hematommate 54.16 µM -0.960746117051609 0.154166874928892 no 2854 0.168339918576628 4117 3940691 An allergen.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.964570904720831 0.153288237260776 no 2855 0.167379889136073 3984 4330530
SGTC_2935 9038016 29.96 µM -0.966766555493595 0.152785350036374 no 2856 0.166830373534211 4057 6463195
SGTC_632 0781-2353 4.65 µM -0.967930447564846 0.152519218882037 no 2857 0.166539553451595 4131 6811515 YHR007C ERG11
SGTC_520 3584-0023 682 µM -0.969169142038829 0.152236321780563 no 2858 0.166230402284634 4061 1340790
SGTC_1854 st056233 32.9 µM -0.970853000327758 0.15185231572363 no 2859 0.165810742745893 3945 5393174
SGTC_2443 5493264 126.67 µM -0.974695001788641 0.150978553676927 no 2860 0.164855786495082 4091 5340055
SGTC_732 3970-1727 52.7 µM -0.974954805110423 0.150919589278434 no 2861 0.164791339406148 4122 1275699
SGTC_753 1322-0200 289 µM -0.982783907573261 0.149149903448856 no 2862 0.1628569018278 4151 5403907
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.982801033468382 0.149146047575135 no 2863 0.162852686562213 4041 756377
SGTC_2218 6965428 192.983 µM -0.982906491201292 0.149122305366571 no 2864 0.162826731388959 3957 675684
SGTC_1736 st036774 51 µM -0.985778162434413 0.148476762395748 no 2865 0.162120992023634 4135 1272247
SGTC_1861 st057647 17.4 µM -0.986672186002816 0.148276170641513 no 2866 0.161901684808321 4155 688668
SGTC_3034 9090421 49.47 µM -0.986678267172617 0.148274806832645 no 2867 0.161900193737484 3935 17173761
SGTC_102 gallobenzophenone 83.616 µM -0.98707739814091 0.148185313070502 no 2868 0.161802348488099 4087 70837
SGTC_2616 abietic acid 100 µM -0.988497158149026 0.147867265270826 no 2869 0.161454612777387 4105 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_4 0960-0234 25.671 µM -0.989030190346435 0.147747976051361 no 2870 0.16132418541066 4080 6821112
SGTC_621 3584-0052 32.1 µM -0.991685890853602 0.147154607719728 no 2871 0.160675387890728 4090 2273927
SGTC_1261 0712-0010 12.7 µM -0.993919640458404 0.146656755368469 no 2872 0.160130995829742 4115 2840123
SGTC_1687 st020778 55.3625 µM -0.994960290430777 0.146425204368399 no 2873 0.159877788961866 4104 4259299
SGTC_2914 7968218 45.32 µM -0.99785076317121 0.145783344646803 no 2874 0.15917586518153 4041 2977111
SGTC_2220 6782180 200 µM -0.997920146218435 0.145767960693792 no 2875 0.159159041014981 3996 833803
SGTC_2828 7998861 71.43 µM -0.999084547410481 0.145509946715228 no 2876 0.158876868049991 4054 2988188
SGTC_2488 5268135 45.7 µM -1.00029721979902 0.145241563238263 no 2877 0.158583346129146 4148 1270356 YLR208W SEC13
SGTC_2949 9072542 2.23 µM -1.00044037936598 0.145209901768989 no 2878 0.158548718480381 4159 16457352
SGTC_2837 9008476 45.46 µM -1.0005084554258 0.145194847554642 no 2879 0.158532253881663 4122 2992805
SGTC_2199 6590217 200 µM -1.00416436908987 0.144387928027301 no 2880 0.157649696644068 3991 703109
SGTC_3193 9111931 49.47 µM -1.00462128744189 0.144287291601642 no 2881 0.157539621451147 4117 17087244
SGTC_3160 9100216 49.47 µM -1.00578550935225 0.144031085077026 no 2882 0.157259379655594 4018 17191039
SGTC_246 cycloheximide 667 µM -1.00662930386627 0.143845585843089 no 2883 0.157056473457731 3980 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1176 0848-0131 83.3 µM -1.00736551864589 0.143683868582906 no 2884 0.156879577549539 4133 6769040
SGTC_2000 st075254 36.4 µM -1.00764664877651 0.143622147798464 no 2885 0.156812062881881 4002 17234175
SGTC_2847 9005661 71.43 µM -1.00817169611506 0.143506924072752 no 2886 0.156686021605426 4088 2991449
SGTC_1798 st045719 60.953 µM -1.00945701738397 0.14322511863444 no 2887 0.156377752769672 3980 3980186
SGTC_3186 9110464 49.47 µM -1.01328330058292 0.142388423415749 no 2888 0.155462430831532 4115 17018021
SGTC_2426 5582046 32.21 µM -1.01386991718667 0.142260440595824 no 2889 0.15532241378763 4119 2251934
SGTC_2312 7706453 155.7 µM -1.01448146237178 0.14212710197199 no 2890 0.155176535278359 4105 976098
SGTC_2744 captopril 92.04 µM -1.0158312011348 0.141833110310577 no 2891 0.154854887650151 4137 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1053 3366-3204 134 µM -1.01794585891419 0.141373337313231 no 2892 0.15435184316601 4143 3632071 YPR165W RHO1
SGTC_1260 0700-1617 7.75 µM -1.01974688224243 0.140982552714753 no 2893 0.153924260428987 4118 2853078
SGTC_1880 MG-132 525 µM -1.0210110965924 0.1407086825474 no 2894 0.153624590698598 4073 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2027 5150920 200 µM -1.02307746521472 0.14026181731987 no 2895 0.153135610362778 4057 786715
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.02435131726605 0.139986819551847 no 2896 0.152834683699111 4082 2724278 An inhibitor of dopamine biosynthesis.
SGTC_159 3970-0959 50 µM -1.02484036933965 0.139881340927441 no 2897 0.152719257411928 4197 6615653
SGTC_1219 1469-0211 33.1 µM -1.02770617530623 0.139264330494687 no 2898 0.152044031057505 4140 6822282
SGTC_1414 3917-0015 5.4 µM -1.02814596010858 0.139169808612873 no 2899 0.151940586996975 4091 6618702
SGTC_3150 9097574 49.47 µM -1.02826732667421 0.139143731280017 no 2900 0.15191204797194 4159 17217476
SGTC_1676 st018489 23.4 µM -1.0288246206586 0.139024031438311 no 2901 0.151781047495796 4148 3696235
SGTC_622 1348-1566 26.3 µM -1.0289798863624 0.138990694778646 no 2902 0.151744563291402 4146 7340407
SGTC_1641 st009299 47.1 µM -1.0305149830532 0.138661391407653 no 2903 0.151384161234907 4026 4046054
SGTC_365 0121-0052 13.6 µM -1.03276200426094 0.138180327630439 no 2904 0.150857644455959 4162 3101739
SGTC_1109 tnp00067 928.257 nM -1.03293720932101 0.138142865938412 no 2905 0.150816642106395 4116 676295
SGTC_2717 st081029 62.2815 µM -1.03302404419607 0.138124301796436 no 2906 0.150796323331982 4100 5292846
SGTC_2520 obtusaquinone 4.71 µM -1.03624236108954 0.137437468164265 no 2907 0.150044544357986 4187 5967872
SGTC_1339 1486-1321 22.7 µM -1.03703856715145 0.137267907139457 no 2908 0.149858941769484 4144 3469382
SGTC_1021 4476-0760 85.3 µM -1.03789555271547 0.137085562150894 no 2909 0.149659342123033 4120 746768
SGTC_1604 st002052 72.4 µM -1.04065832088272 0.136498841614461 no 2910 0.149017076711527 4204 6254834 YHR062C RPP1
SGTC_2479 5617353 43.85 µM -1.04072639432674 0.136484406781304 no 2911 0.149001274840433 4179 2731746
SGTC_545 4218-0007 221 µM -1.04510096040812 0.135558978006596 no 2912 0.147988155121372 4141 2840508
SGTC_1503 4585-0012 61.3 µM -1.046413629085 0.135282126693436 no 2913 0.147685051474566 4197 2922052
SGTC_3071 9117417 49.47 µM -1.047816735918 0.134986630160492 no 2914 0.147361525114266 4096 45595590 YGL055W OLE1
SGTC_1345 1488-0192 31.4 µM -1.0478809921648 0.134973108301961 no 2915 0.147346720383273 4193 658348
SGTC_216 k038-0035 28.382 µM -1.04910317553352 0.134716093216881 no 2916 0.147065317375637 4075 4444231 YPR107C YTH1
SGTC_1268 0828-0275 2.46 µM -1.04995896978665 0.134536326779693 no 2917 0.14686848869235 4199 745337
SGTC_2056 5235370 200 µM -1.05020350467037 0.134484990531017 no 2918 0.146812279284795 4081 5511916
SGTC_297 0986-0032 24 µM -1.05034303952674 0.134455703411791 no 2919 0.146780211917101 4082 2847425
SGTC_2625 euphol 100 µM -1.05107041097457 0.134303105554613 no 2920 0.146613126286806 4177 6708538 A triterpene alcohol.
SGTC_353 1988-1175 58.3 µM -1.05132469649346 0.134249786154846 no 2921 0.146554744087064 3987 2788357
SGTC_2884 9058502 51.95 µM -1.05135419446974 0.134243601866183 no 2922 0.146547972565503 4187 6471554
SGTC_1240 0356-0016 42.1 µM -1.05200206475549 0.134107824367316 no 2923 0.14639930116207 4120 4305613
SGTC_2204 7233102 200 µM -1.05220768020196 0.134064752212805 no 2924 0.146352138298453 4049 2172480
SGTC_3183 9108214 49.47 µM -1.05389027477559 0.133712640807486 no 2925 0.14596657796982 4074 4974831
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.0584940030886 0.132752484348882 no 2926 0.144915141674552 4147 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_178 4092-0806 87.505 µM -1.06472581218107 0.131460354646149 no 2927 0.143500012878357 4041 2169044
SGTC_2678 equilin 100 µM -1.06523211859052 0.131355757600551 no 2928 0.143385451193745 4166 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_638 3970-0837 4.09 µM -1.06838775794134 0.130705134293434 no 2929 0.142672818449008 4133 4118451 YLR208W SEC13
SGTC_3305 9127027 53.8275 µM -1.07078884110236 0.130211578671639 no 2930 0.142132192751555 4090 41905295
SGTC_979 1426-2828 121 µM -1.07105228306174 0.130157505363034 no 2931 0.142072960918506 4268 747872
SGTC_280 3448-3607 3.04 µM -1.07118340219535 0.130130598034292 no 2932 0.142043486548354 4133 626179
SGTC_3048 9093155 49.47 µM -1.07163602444517 0.1300377437213 no 2933 0.141941773054909 4135 25236002
SGTC_247 mechlorethamine 29.705 µM -1.07670229717028 0.129001539630859 no 2934 0.14080664289483 4071 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_332 4112-0506 40.9 µM -1.08813181999398 0.126684931366398 no 2935 0.138268459095023 4133 2790355
SGTC_2221 6807166 181.081 µM -1.0895661027463 0.126396280733082 no 2936 0.137952160834311 4149 674925
SGTC_501 nsc-95397 161 µM -1.09010241057921 0.126288466122472 no 2937 0.137834017282377 4220 262093
SGTC_1804 st050076 49.1 µM -1.09065297355098 0.126177852468788 no 2938 0.137712805285453 4200 3895976
SGTC_1214 0358-0031 63.7 µM -1.09129979980291 0.126047984848794 no 2939 0.137570492913188 4293 4301366
SGTC_995 3931-2021 34.6 µM -1.09141762001508 0.12602433933615 no 2940 0.137544581348375 4192 730143
SGTC_401 neomycin 50 µM -1.09203156998099 0.125901174856679 no 2941 0.137409612552475 4150 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1698 5-fluorocytosine 1.055 µM -1.09353098305252 0.12560073058204 no 2942 0.137080366598908 4199 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_684 1140-0066 328 µM -1.09638246745473 0.125030746736021 no 2943 0.13645571665714 4232 6813534
SGTC_840 0245-0196 390 µM -1.0988685925124 0.124535271027199 no 2944 0.135912693919547 4269 3827528
SGTC_3232 9132874 49.47 µM -1.09896151637722 0.124516778288055 no 2945 0.1358924260912 4144 3784940
SGTC_3137 9097352 49.47 µM -1.10210153373746 0.123893013029354 no 2946 0.135208766348025 4234 44120435
SGTC_2927 9011802 47.9 µM -1.10342230659237 0.123631295706037 no 2947 0.134921907035129 4208 43912568
SGTC_1723 st034307 2.5525 µM -1.1061114071114 0.123099634991297 no 2948 0.134339150981225 4224 867466
SGTC_575 k072-0246 11.9 µM -1.10681994544237 0.122959817381718 no 2949 0.134185891493296 4279 6796779
SGTC_2080 5212524 12.4 µM -1.1078341908071 0.122759867673568 no 2950 0.13396671550853 4118 260183
SGTC_381 3461-2219 42.7 µM -1.10825361171853 0.122677249151928 no 2951 0.13387615159734 4200 2883159
SGTC_3327 9140648 26.9345 µM -1.10950049134874 0.122431866215517 no 2952 0.133607166295668 4225 8029710
SGTC_2840 9008771 71.43 µM -1.11133454395714 0.122071555320516 no 2953 0.133212187806678 4146 2992978
SGTC_1291 0993-0025 5.79 µM -1.11559642168692 0.121237160688746 no 2954 0.132297462250802 4205 4353356
SGTC_2193 5925765 200 µM -1.11701940214631 0.120959463437414 no 2955 0.131993014745328 4207 877370
SGTC_2524 avocatin b 10.57 µM -1.11959146384784 0.120458657120545 no 2956 0.131443947407222 4189 6710748
SGTC_1229 0139-0193 12.2 µM -1.12141777694579 0.120103943293397 no 2957 0.131055036334303 4292 3090752
SGTC_1579 chlormadinone acetate 49.4 µM -1.12374583734356 0.119652846191092 no 2958 0.130560432394217 4256 45114258 A steroidal progestin.
SGTC_2845 9003024 42.97 µM -1.12512766817611 0.119385661266982 no 2959 0.130267469174408 4274 2990173
SGTC_1231 0242-0792 125 µM -1.12813636199775 0.118805369981427 no 2960 0.129631167337607 4206 3707635
SGTC_3162 9099653 49.47 µM -1.12813831908471 0.118804993164683 no 2961 0.12963075413959 4184 25237511
SGTC_1422 4031-0024 15.5 µM -1.12922035501296 0.118596787644275 no 2962 0.129402444535277 4144 782427
SGTC_1076 itraconazole 331 nM -1.13118660075798 0.118219102571275 no 2963 0.128988280195466 4227 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1959 st077091 55.8 µM -1.13633902166559 0.11723343975252 no 2964 0.127907352759288 4214 821356 YKL052C ASK1
SGTC_2249 haloperidol 116.36 µM -1.13648096206526 0.117206369063932 no 2965 0.127877664404297 4193 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1644 st010134 20.9 µM -1.13754828210334 0.117002953004575 no 2966 0.127654576361658 4211 3818134
SGTC_2549 cedrol 20.94 µM -1.13995204501534 0.116545746400917 no 2967 0.127153140232729 4172 6708665 A sedative which affects the nervous system.
SGTC_1498 4478-3555 97.6 µM -1.1444368013116 0.115696115821775 no 2968 0.126221266703317 4217 3437919
SGTC_2420 aureobasidin a 50 nM -1.14455333818404 0.115674096880459 no 2969 0.126197115487839 4345 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_291 SEC14.278 35.5 µM -1.14610900140817 0.115380448723268 no 2970 0.125875026779815 4282 1068044
SGTC_827 3253-0474 693 µM -1.1491637816669 0.114805368541876 no 2971 0.125244226128821 4269 5402065
SGTC_3042 9091578 49.47 µM -1.15038964878125 0.114575166211932 no 2972 0.124991710798619 4219 25236497
SGTC_2025 5147754 141 µM -1.15055564169327 0.114544020115722 no 2973 0.124957545416858 4211 315777 YLR208W SEC13
SGTC_2003 4023581 200 µM -1.15270058824956 0.114142094827997 no 2974 0.124516649960333 4274 16641307
SGTC_2182 6325192 200 µM -1.15272318284656 0.114137866350877 no 2975 0.124512011419096 4225 736248
SGTC_2362 9071156 126 µM -1.15448827631389 0.113807881800068 no 2976 0.124150021145105 4248 653133
SGTC_700 3453-2283 142 µM -1.15468563043086 0.113771028715125 no 2977 0.124109593023829 4294 565664
SGTC_3067 9117431 49.47 µM -1.15477584676377 0.113754184926331 no 2978 0.124091115216415 4270 17150885
SGTC_2789 5281112 71.43 µM -1.15628571368248 0.113472549849546 no 2979 0.123782154975254 4264 765948
SGTC_3076 9116187 49.47 µM -1.15765832491415 0.113216948843132 no 2980 0.123501748687297 4233 27241210
SGTC_1752 st044819 83.042 µM -1.15908672535802 0.112951395462021 no 2981 0.123210418126908 4227 441209 YML126C ERG13
SGTC_3240 9133527 49.47 µM -1.15912302255088 0.112944653261843 no 2982 0.123203021383532 4198 17617455
SGTC_2374 9071832 200 µM -1.15981511499246 0.1128161521097 no 2983 0.123062044385048 4173 17381698
SGTC_2803 7707263 71.43 µM -1.1604054598675 0.112706624996368 no 2984 0.122941882433107 4230 2199229
SGTC_413 propylparaben 100 µM -1.16067821087958 0.112656046956268 no 2985 0.122886393026676 4210 7175 A pharmaceutical preservative.
SGTC_2860 9025725 38.96 µM -1.16302682792667 0.112221197854229 no 2986 0.122409308894958 4291 40546248
SGTC_3177 9107506 49.47 µM -1.16451576122371 0.111946142250046 no 2987 0.122107529907147 4205 8897194
SGTC_2761 levamisole 97.89 µM -1.166896477323 0.111507346836978 no 2988 0.121626089346812 4271 26879 An alkaline phosphatase inhibitor.
SGTC_2084 5306078 60.6385 µM -1.16759919155396 0.111378063492545 no 2989 0.121484238230544 4178 679340
SGTC_1434 4073-0095 163 µM -1.17118969534107 0.110719167423586 no 2990 0.120761268189484 4244 24133745
SGTC_2880 9042983 58.44 µM -1.17225404547976 0.110524385540637 no 2991 0.120547537853738 4227 6464714
SGTC_1364 1653-0028 37.6 µM -1.17252482011615 0.110474871523505 no 2992 0.120493206588311 4254 5718652
SGTC_1874 staurosporine 7.6 µM -1.1733865361779 0.110317403429695 no 2993 0.120320416967701 4270 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3323 9138564 53.9225 µM -1.17381700775832 0.110238800316108 no 2994 0.120234165056327 4279 43912313 YNL103W MET4
SGTC_179 1273-0063 6.77 µM -1.17414144569227 0.110179585251944 no 2995 0.120169187488031 4220 3108139
SGTC_2898 9056270 58.44 µM -1.17518946641578 0.109988460753906 no 2996 0.119959461752388 4254 19154699
SGTC_1799 st045822 46.1415 µM -1.17542592439321 0.109945371509785 no 2997 0.119912178418463 4246 3674992
SGTC_1089 terbinafine 2.25 µM -1.17579229499971 0.109878632484723 no 2998 0.119838943049511 4273 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_135 0933-0004 26.348 µM -1.17652914195596 0.109744494571089 no 2999 0.119691747102721 4241 21230617 YGL099W LSG1
SGTC_283 0987-0079 11.7 µM -1.17852561740407 0.109381640796149 no 3000 0.119293562869784 4260 411556
SGTC_67 0335-0847 266 µM -1.17900816846478 0.109294067966376 no 3001 0.119197461601145 4363 4552207 YOR254C SEC63
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.17957653429908 0.109190986182776 no 3002 0.119084340206281 4175 6708630 An antioxidant.
SGTC_3024 9090631 49.47 µM -1.18092377168094 0.108946923299325 no 3003 0.118816503450254 4235 25236383
SGTC_2620 irigenin 100 µM -1.18209684073581 0.108734732001344 no 3004 0.118583638911703 4300 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1247 0448-0043 5.84 µM -1.18312490673192 0.10854901416784 no 3005 0.118379824081304 4284 3089013 YGL099W LSG1
SGTC_2997 9067075 71.4286 µM -1.18329123690622 0.108518988450133 no 3006 0.118346872290409 4265 27209819
SGTC_1806 st050005 60.3 µM -1.18373406161164 0.108439079410459 no 3007 0.118259175581893 4319 5194765
SGTC_1004 4084-0029 199 µM -1.18424925693476 0.108346164167571 no 3008 0.118157204481508 4285 716894 YLR208W SEC13
SGTC_1493 4348-0038 111 µM -1.18748899511871 0.10776319155723 no 3009 0.117517397428937 4242 800424
SGTC_112 phenothiazine 287.218 µM -1.18926162379724 0.107445175062233 no 3010 0.117168365838307 4231 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1505 k297-0037 20.6 µM -1.1893990010811 0.107420557314157 no 3011 0.117141346868394 4270 4089396
SGTC_2329 6138490 200 µM -1.19475324811185 0.106464251362083 no 3012 0.116091725697102 4349 720019
SGTC_1207 2099-0101 141 µM -1.19638999377816 0.106173147544203 no 3013 0.115772202152254 4278 5837381
SGTC_608 k048-0125 159 µM -1.2005592328844 0.105434225210699 no 3014 0.114961111429591 4325 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2491 paeonol 100 µM -1.20280888024356 0.105037064301278 no 3015 0.114525143786203 4232 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1368 1852-0141 284 µM -1.20528019123065 0.104602019534911 no 3016 0.114047577002146 4294 2838987
SGTC_2870 9038528 12.99 µM -1.20635616558437 0.10441301550808 no 3017 0.113840094988517 4330 6463316
SGTC_329 k048-0121 21.3 µM -1.20804000964357 0.104117730866657 no 3018 0.113515936519363 4312 6832902
SGTC_168 3970-0862 530.542 µM -1.20883732259752 0.103978122744376 no 3019 0.113362674846489 4254 3135186
SGTC_2626 ethyl orsellinate 100 µM -1.20919324793194 0.103915844676784 no 3020 0.113294305575899 4257 75653 A natural product.
SGTC_1098 clofazimine 15.1 µM -1.21348914337789 0.1031663028031 no 3021 0.112471431339046 4354 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2584 androsterone 48.74 µM -1.2145648354378 0.102979233702419 no 3022 0.112266053739421 4229 2754130 A steroid.
SGTC_2237 6667747 47.222 µM -1.21749211546635 0.10247141064231 no 3023 0.111708517243837 4312 729940 YDL015C TSC13
SGTC_2964 9083345 53.42 µM -1.21975031880601 0.102080904568517 no 3024 0.111279770018014 4281 17741579
SGTC_2476 5806916 10.51 µM -1.22983463151561 0.100350258140429 no 3025 0.109379518412062 4197 2870194
SGTC_1948 st076329 66.6 µM -1.2301575241675 0.100295200024153 no 3026 0.109319061179567 4226 24208413
SGTC_3336 9143619 71.43 µM -1.23211813848148 0.0999613587411276 no 3027 0.108952478349702 4338 45595730
SGTC_1491 4138-0063 26.5 µM -1.23251792159677 0.0998933858653354 no 3028 0.108877838107985 4302 23883227
SGTC_2277 7947813 106.88 µM -1.23281329839773 0.0998431862979133 no 3029 0.108822714336456 4343 1246798
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.23608171111215 0.0992889460473514 no 3030 0.108214096151756 4380 165506
SGTC_2150 5556613 200 µM -1.23877989657106 0.0988330996541504 no 3031 0.107713510405836 4337 743190
SGTC_1849 st056239 19.2 µM -1.24262001128378 0.0981869728746258 no 3032 0.107003946099529 4308 5393181
SGTC_219 mitoxanthrone 164.414 µM -1.24445525895279 0.0978792744075058 no 3033 0.106666028073555 4249 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_968 1309-0633 340 µM -1.24614932881933 0.0975958737108374 no 3034 0.10635478887337 4355 3761976
SGTC_152 4469-0003 551.229 µM -1.24614956044857 0.0975958350028035 no 3035 0.106354746362696 4304 697280
SGTC_2456 5770359 74.46 µM -1.24631922343136 0.0975674852994432 no 3036 0.106323611586414 4329 3118787
SGTC_898 1000-0849 28.3 µM -1.24668451614954 0.0975064674982483 no 3037 0.106256599230839 4333 6751807
SGTC_2769 toremifene 3.73 µM -1.24704169536835 0.0974468320269862 no 3038 0.106191104785387 4348 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3170 9103054 49.47 µM -1.24835809558943 0.0972272737889636 no 3039 0.105949973828033 4302 16432970
SGTC_3084 9116877 49.47 µM -1.25117796109388 0.0967581793415296 no 3040 0.105434778523965 4275 27241325
SGTC_2439 5492030 7.2 µM -1.25290242784994 0.0964721285124538 no 3041 0.10512060911243 4326 5722370
SGTC_1270 0831-1170 17.3 µM -1.25294734681789 0.0964646857630619 no 3042 0.105112434680428 4333 6764716
SGTC_3061 glucosamine 200 µM -1.25306390951447 0.0964453741318729 no 3043 0.105091224543778 4271 91431 and experimental redox chemotherapeutic
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.25435094792453 0.0962323316887385 no 3044 0.104857236644942 4315 688667
SGTC_781 4335-2806 94.4 µM -1.2580828249054 0.0956165530462627 no 3045 0.104180902015527 4390 845254
SGTC_468 gf-109203x 121 µM -1.25964155584147 0.0953602147456064 no 3046 0.103899348711866 4355 2396 A protein kinase C inhibitor.
SGTC_2246 7293507 91.5585 µM -1.26168038353647 0.0950256871121349 no 3047 0.103531909170823 4397 887656
SGTC_3157 9099274 49.47 µM -1.26342392440118 0.0947402960477699 no 3048 0.103218435342159 4358 17217662
SGTC_2906 7926292 26.41 µM -1.26351882532613 0.0947247803590345 no 3049 0.103201392761421 4342 2966319
SGTC_3297 9117502 71.43 µM -1.26449232069021 0.0945657282721068 no 3050 0.103026687644097 4367 7453720
SGTC_1020 4335-0961 93.3 µM -1.26881492763664 0.0938618675942994 no 3051 0.102253539874107 4299 669075
SGTC_3044 9093193 49.47 µM -1.27108220200364 0.0934942313658326 no 3052 0.101849703173814 4364 25236277
SGTC_1171 0368-0077 21.4 µM -1.27229819288668 0.0932974983609137 no 3053 0.101633595215316 4303 3239779
SGTC_2473 5854593 8.94 µM -1.27314673343318 0.0931603957862791 no 3054 0.101482989069877 4251 2872951
SGTC_2406 ethylparaben 405.7 µM -1.27352682719039 0.0930990306072419 no 3055 0.101415579557289 4334 8434 A possible steroid mimic.
SGTC_784 4579-0127 173 µM -1.27357197279265 0.0930917439489223 no 3056 0.101407575166002 4373 1948547
SGTC_2014 4013930 200 µM -1.2737938194068 0.0930559432532273 no 3057 0.101368248074839 4314 64556
SGTC_3094 9117742 49.47 µM -1.2776312242819 0.092438288138092 no 3058 0.100689742811934 4298 17149698
SGTC_175 3793-3120 23.7 µM -1.27995363241764 0.0920659579625112 no 3059 0.100280721816611 4345 5322297
SGTC_285 1486-1325 46 µM -1.28004511737738 0.0920513137918293 no 3060 0.100264634408656 4395 22310230
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.28110456354131 0.0918818518566127 no 3061 0.100078470577364 4353 140250 A respiratory chain inhibitor.
SGTC_657 3534-0529 86.7 µM -1.28161341245538 0.0918005419689245 no 3062 0.0999891464004638 4386 1049549
SGTC_2603 homopterocarpin 100 µM -1.28199171501087 0.0917401268714095 no 3063 0.0999227762873636 4323 101795 A weak amylase inhibitor.
SGTC_3271 9137798 49.47 µM -1.28400550557933 0.0914190192270664 no 3064 0.0995700145235751 4312 6498326
SGTC_2525 harmine 47.85 µM -1.28481225509616 0.0912906135106833 no 3065 0.0994289494031856 4336 5280953 A monoamine oxidase inhibitor
SGTC_763 3453-1109 128 µM -1.28530803718105 0.0912117690714001 no 3066 0.0993423313578933 4385 1560353
SGTC_85 0868-0259 160.055 µM -1.28984511223074 0.0904925801656266 no 3067 0.0985522206008657 4281 83173
SGTC_824 1304-0008 100 µM -1.29971027510344 0.0889433600178742 no 3068 0.0968501436837931 4391 768245
SGTC_3100 9120536 49.47 µM -1.30292969755496 0.0884420810339879 no 3069 0.096299382015074 4240 16421196
SGTC_2690 usnic acid 100 µM -1.30462711283196 0.0881786345910348 no 3070 0.0960099256867325 4384 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2757 clomiphene 4.22 µM -1.30796540734036 0.0876622236084846 no 3071 0.0954425213505273 4393 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.31161902704566 0.0870996239023083 no 3072 0.0948243549399862 4261 4000243
SGTC_2763 lisinopril 49.32 µM -1.313414751361 0.0868241010667023 no 3073 0.0945216147407322 4279 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2518 prenyletin 46.28 µM -1.31485892212864 0.0866029909157168 no 3074 0.0942786602148061 4385 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1501 4491-0275 38.4 µM -1.31532478050148 0.0865317554046082 no 3075 0.0942003866562677 4370 5104718
SGTC_72 0744-0168 198.391 µM -1.31583727448338 0.0864534393421584 no 3076 0.0941143327666771 4264 677577
SGTC_473 2-arachidonoylglycerol 10 µM -1.31681882941028 0.0863035923433438 no 3077 0.0939496798537355 4195 5282280 An endocannabinoid.
SGTC_1424 4048-1941 275 µM -1.32229916968361 0.0854705158967697 no 3078 0.0930342745799021 4449 X1424
SGTC_1340 1486-1359 257 µM -1.32241300127121 0.0854532762245645 no 3079 0.0930153309312257 4320 4309068
SGTC_2402 5553605 200 µM -1.32246248685312 0.0854457824983484 no 3080 0.093007096518669 4457 6758546
SGTC_546 peri-Naphthalide 147 µM -1.32487649426438 0.0850808206373692 no 3081 0.092606059130191 4329 223824 A penicillin ester.
SGTC_1139 k015-0024 46.9 µM -1.32756356195005 0.0846759515147402 no 3082 0.0921611643914761 4414 2766652
SGTC_779 1360-0071 233 µM -1.33271635174439 0.0839036089636888 no 3083 0.0913124525494055 4424 7566
SGTC_2886 9058944 51.95 µM -1.33380789897767 0.0837406800648127 no 3084 0.0911334108015796 4311 4949929
SGTC_149 3970-0822 46.1 µM -1.33459352408788 0.0836235615470587 no 3085 0.0910047093443594 4375 3114250 YBL034C STU1
SGTC_862 0452-0056 10.2 µM -1.33497365114291 0.0835669376022692 no 3086 0.0909424851804994 4351 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2650 prasterone 100 µM -1.33650080010272 0.0833397429705533 no 3087 0.0906928195795877 4391 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_132 0417-1715 25.805 µM -1.3378798537072 0.0831349797951854 no 3088 0.0904678027285061 4380 6769098
SGTC_2022 5136654 200 µM -1.34161482249154 0.0825823081682699 no 3089 0.0898604588185872 4400 1713771
SGTC_2041 5107442 45.335 µM -1.34451231334981 0.0821554683866766 no 3090 0.0893913886856664 4430 793005
SGTC_2745 rifampicin 24.3 µM -1.34503271103045 0.0820789830916489 no 3091 0.0893073356303064 4483 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_163 TUB2.036 7.546 µM -1.34783736713513 0.08166769298693 no 3092 0.0888553482383228 4348 15992207 YJR013W GPI14
SGTC_775 4577-0580 57.3 µM -1.34830471324609 0.0815993100856121 no 3093 0.088780198410156 4428 2006902
SGTC_3219 9131112 49.47 µM -1.35097803325666 0.0812089748013399 no 3094 0.0883512347436709 4267 17612988 YMR079W SEC14
SGTC_1467 k284-1082 293 µM -1.36091428058672 0.0797705131133328 no 3095 0.0867703900136178 4380 3334705
SGTC_1138 3761-0006 1.03 µM -1.3613110525107 0.0797134755554939 no 3096 0.086707705824813 4434 12061087
SGTC_14 0354-0009 295 µM -1.36272527430983 0.0795104264316319 no 3097 0.0864845546417226 4494 1713507
SGTC_454 lyso-paf C-16 6.67 µM -1.36297034103022 0.0794752804146559 no 3098 0.0864459290560898 4426 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_212 3807-4682 38.772 µM -1.36309619044291 0.0794572364072617 no 3099 0.086426098625023 4472 3125501 YBL034C STU1
SGTC_1242 0402-0103 60.1 µM -1.36429426848686 0.0792856138790148 no 3100 0.0862374845303546 4338 432868
SGTC_2610 ononetin 44.17 µM -1.36456206347226 0.0792472911298218 no 3101 0.0861953675468832 4377 259632
SGTC_1319 1306-0155 43.7 µM -1.37221733432397 0.0781577062101198 no 3102 0.0849978953600396 4459 3122360
SGTC_2814 7977482 42.97 µM -1.37646257742316 0.0775583933347627 no 3103 0.0843392328088974 4421 6456762
SGTC_1811 st050069 61.5 µM -1.37985350424427 0.0770821985934878 no 3104 0.08381587746538 4406 3877702
SGTC_1730 st033808 45.1 µM -1.38075926350479 0.0769553777657637 no 3105 0.083676496325399 4340 1045166
SGTC_2331 7980721 200 µM -1.38154207673559 0.0768458991778651 no 3106 0.0835561748598622 4382 2981221
SGTC_2919 7978188 46.38 µM -1.38284359374304 0.0766641405836139 no 3107 0.0833564144283563 4435 2980291
SGTC_2278 7948257 134.34 µM -1.38319825761342 0.076614668027644 no 3108 0.0833020419274465 4429 1247028
SGTC_3081 9117243 49.47 µM -1.38804555647529 0.0759409431122291 no 3109 0.0825615866580909 4395 45595589
SGTC_2638 epoxomicin 18 µM -1.39340007988139 0.07520197361706 no 3110 0.0817494207957024 4402 9915668 A protesome inhibitor.
SGTC_2658 polymyxin b sulfate 77.05 µM -1.39414462645917 0.0750996555578242 no 3111 0.08163696769917 4451 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_741 4582-0002 126 µM -1.39437725771082 0.0750677083759118 no 3112 0.0816018560040045 4446 2912688
SGTC_116 0155-0182 31.788 µM -1.39872058336702 0.0744731421762394 no 3113 0.0809483946568133 4297 771486
SGTC_3338 9144300 39.5675 µM -1.40047328334466 0.0742342323401138 no 3114 0.080685819192472 4435 4901274
SGTC_1825 st052143 62.6 µM -1.40324542505624 0.0738575584447287 no 3115 0.0802718330781911 4467 674173
SGTC_496 calpeptin 138 µM -1.4070798269917 0.0733389561581884 no 3116 0.0797018596094986 4437 73364 A calpain inhibitor.
SGTC_1727 st034309 9.9045 µM -1.40989753056037 0.0729596410438617 no 3117 0.0792849709810907 4468 870305
SGTC_80 0159-0065 512.242 µM -1.41399256671316 0.0724110527399592 no 3118 0.078682042505375 4379 1548079
SGTC_3214 9129694 49.47 µM -1.41634074441447 0.0720979097560317 no 3119 0.0783378819684145 4465 17158655
SGTC_2843 9000894 45.46 µM -1.41711587285845 0.0719947701401775 no 3120 0.0782245262651123 4416 2242070
SGTC_1086 cerivastatin 2.18 µM -1.41920872276045 0.0717168578323053 no 3121 0.0779190868315545 4442 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_169 k015-0017 16.025 µM -1.42840179626571 0.0705058352876712 no 3122 0.0765881212285438 4445 1840002
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.42848787150241 0.0704945711668491 no 3123 0.0765757415549105 4472 77254
SGTC_3235 9132602 49.47 µM -1.42856727611825 0.0704841812146864 no 3124 0.0765643226254983 4445 4912240
SGTC_120 rhodamine 6G 52.259 µM -1.4321857608161 0.0700119570086786 no 3125 0.0760453328562297 4465 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2436 5633522 8.09 µM -1.43258690599645 0.069959756476557 no 3126 0.0759879629676025 4438 5724242
SGTC_2012 4023501 200 µM -1.43639089218129 0.0694662358345945 no 3127 0.0754455716681542 4446 3477460
SGTC_1570 verbenone 133 µM -1.43657304313385 0.0694426714169201 no 3128 0.0754196738946594 4475 29025 A natural terpanoid with antifungal properties.
SGTC_522 1273-0010 11.6 µM -1.43964254423924 0.0690465029996578 no 3129 0.0749842782289649 4482 5705015
SGTC_1213 1315-0166 115 µM -1.44575067387056 0.0682633352652231 no 3130 0.0741235728301107 4460 768401
SGTC_3063 1327-0034 4 µM -1.45560807693385 0.0670139281957784 no 3131 0.0727504969842702 4350 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1392 3455-1037 33.9 µM -1.45982574501942 0.0664847803227409 no 3132 0.0721689855284309 4462 981132
SGTC_1338 1486-1223 76 µM -1.45991390547086 0.0664737543413583 no 3133 0.0721568685217103 4480 3444526
SGTC_2965 9082772 38.63 µM -1.46195913061499 0.0662183609120319 no 3134 0.0718762048465439 4467 16459634
SGTC_2854 9024559 71.43 µM -1.46504236001289 0.0658347860363266 no 3135 0.071454680500699 4480 3163529
SGTC_3127 9126946 49.47 µM -1.4691554730375 0.0653257702946586 no 3136 0.0708953122006585 4425 27243249
SGTC_2545 solidagenone 89.61 µM -1.47165960452321 0.0650173714897156 no 3137 0.0705564105848231 4392 6708572 An anti ulcer agent
SGTC_1334 1486-0610 236 µM -1.47414484260557 0.0647124180000694 no 3138 0.0702212985093945 4537 3742339
SGTC_1289 0976-0073 69.1 µM -1.47632122731418 0.0644462759849117 no 3139 0.0699288391151844 4536 3391136
SGTC_1492 4158-0558 28.5 µM -1.48114867598092 0.0638589809259101 no 3140 0.0692834796504808 4490 3967268
SGTC_75 0159-0059 199.013 µM -1.48249682040917 0.0636957149085164 no 3141 0.0691040745002727 4540 5377270
SGTC_1626 st003712 1.76 µM -1.48876136728342 0.0629413087493667 no 3142 0.068275109382683 4490 24207035
SGTC_3105 9121040 49.47 µM -1.48926668808339 0.0628807603204619 no 3143 0.0682085780125691 4448 41448907
SGTC_2640 pentamidine 10.38 µM -1.49021454940308 0.0627673083134264 no 3144 0.0680839160018116 4448 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2032 5185112 25.99 µM -1.49398603530219 0.0623174686711263 no 3145 0.0675896346501243 4378 5718189
SGTC_1954 st077032 68.9 µM -1.50099639327484 0.0614880008885353 no 3146 0.0666782472196235 4427 698907
SGTC_274 sirtinol 40.1 µM -1.50244777931786 0.0613173547608491 no 3147 0.0664907523964468 4533 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.50398849442299 0.0611366109039461 no 3148 0.066292164630252 4487 803109
SGTC_1924 st058459 75.1 µM -1.51574382601656 0.0597712493190914 no 3149 0.0647920705678488 4456 688683
SGTC_1671 st016596 74.5 µM -1.51626778130702 0.0597109534860128 no 3150 0.0647258274856073 4559 2829167
SGTC_58 0957-0393 9 µM -1.51745186532783 0.0595748667753265 no 3151 0.0645763188046963 4084 6997992
SGTC_2096 5468907 200 µM -1.51827631195734 0.0594802567971354 no 3152 0.0644723783465783 4506 759785
SGTC_571 k831-0106 44.2 µM -1.52204597201684 0.0590491662170865 no 3153 0.0639987810380021 4400 4783639
SGTC_1667 st014849 34.6 µM -1.52216089377031 0.0590360626016598 no 3154 0.0639843855686399 4594 5348460
SGTC_2890 9046729 58.44 µM -1.52539047843353 0.0586687506623467 no 3155 0.0635808661180572 4490 903329
SGTC_3226 9131256 49.47 µM -1.53505019072963 0.057580818800453 no 3156 0.062385749927472 4525 17178073
SGTC_2430 5571206 200 µM -1.53973900685765 0.0570584892738112 no 3157 0.0618119923062062 4490 1731771
SGTC_801 0866-0028 10.1 µM -1.54016973528041 0.0570106942240855 no 3158 0.0617594924974522 4549 6849771
SGTC_2645 abamectin 100 µM -1.54253081690323 0.0567492605264852 no 3159 0.0614723276140767 4460 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1607 st000305 50.6 µM -1.54562976132051 0.0564075602246559 no 3160 0.0610970046574569 4523 5457690
SGTC_8 0354-0001 70 µM -1.5460306968904 0.0563634704091645 no 3161 0.0610485772139179 4518 4993152
SGTC_1797 st048695 56.8 µM -1.54624118232842 0.0563403347629573 no 3162 0.0610231655120813 4482 592262 YIL048W NEO1
SGTC_63 0099-0242 26.702 µM -1.55199080898073 0.0557112511043667 no 3163 0.060332211400737 4532 3898502 YLR359W ADE13
SGTC_2411 st077133 39.94 µM -1.55604026203839 0.0552715249592037 no 3164 0.0598492593404022 4488 1403142 YNL221C POP1
SGTC_2771 fluoxetine 41.05 µM -1.55836834556096 0.055019964351239 no 3165 0.0595729779567682 4518 3386 A selective serotonin reuptake inhibitor.
SGTC_1200 1643-0193 18.4 µM -1.56608494944632 0.0541926123092298 no 3166 0.0586643655329391 4547 5403974
SGTC_81 0411-0046 9.971 µM -1.56979744777196 0.053798092110246 no 3167 0.0582311207723279 4528 12925265
SGTC_2740 felodipine 17.08 µM -1.57713337345979 0.0530252069866131 no 3168 0.057382419759062 4593 3333 L-type calcium channel blocker
SGTC_2177 5811945 192 µM -1.57719273390956 0.0530189891013898 no 3169 0.0573755921947495 4541 5343475
SGTC_452 diindolylmethane 8 µM -1.57929411150951 0.0527992464149425 no 3170 0.0571343059420829 4529 3071 Inhibits expression of several cancer promoting factors.
SGTC_127 0180-0333 59.125 µM -1.58457828566405 0.0522498685281887 no 3171 0.0565310908896831 4447 771601
SGTC_2797 7859098 81.82 µM -1.5849659052191 0.0522097484022306 no 3172 0.0564870404863159 4503 972681
SGTC_487 nimodipine 119 µM -1.58742010986209 0.0519562962688654 no 3173 0.0562087638448534 4556 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1495 4469-0029 237 µM -1.58756895034908 0.0519409566202621 no 3174 0.0561919219890968 4544 793680
SGTC_1078 idebenone 36.1 µM -1.58769496268423 0.0519279724769128 no 3175 0.056177666334337 4561 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1446 4239-0190 62 µM -1.58886627591373 0.0518074052896549 no 3176 0.0560452932003048 4543 1340085
SGTC_1946 st076057 65.1 µM -1.59425755455606 0.0512553291177816 no 3177 0.0554391801507227 4536 953009
SGTC_1827 berberine 7.24 µM -1.59548965006156 0.0511298198216129 no 3178 0.0553013913170347 4454 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1314 1222-0010 41.1 µM -1.59977419651803 0.0506952709341313 no 3179 0.054824342535019 4545 3526027
SGTC_1521 st012942 49.4 µM -1.60000891509588 0.0506715504587988 no 3180 0.0547983028367347 4462 24207259
SGTC_395 anisomycin 6.25 µM -1.6018954717087 0.0504812174321466 no 3181 0.0545893630133304 4559 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_692 k241-0027 77.8 µM -1.60198870074397 0.0504718264269794 no 3182 0.0545790540735981 4564 3600480
SGTC_321 4534-3890 65.3 µM -1.6024817294678 0.0504221865501463 no 3183 0.0545245622820736 4553 699746
SGTC_1793 st048256 72.231 µM -1.60576209237006 0.050092897753753 no 3184 0.0541630962924857 4526 672022
SGTC_404 fumagillin 50 µM -1.60603883458126 0.0500651964732694 no 3185 0.0541326887784549 4550 12015870 A methionine aminopeptidase binder.
SGTC_2248 tofa 1.1 µM -1.60705468869004 0.0499636164262186 no 3186 0.0540211859107141 4572 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1801 st050089 28.441 µM -1.62404130490567 0.0482892765167952 no 3187 0.0521834967150291 4593 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_354 2783-3500 4.88 µM -1.62623215494884 0.0480766350123599 no 3188 0.0519501391258523 4537 6740761
SGTC_3224 9130643 49.47 µM -1.62667898531179 0.0480333582834716 no 3189 0.0519026471085075 4559 17644395
SGTC_1084 voriconazole 435 nM -1.62850392829422 0.0478569312261562 no 3190 0.051709038479818 4575 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_932 2857-0803 154 µM -1.62889127867983 0.047819550807024 no 3191 0.0516680183380823 4558 674898
SGTC_1254 0550-0035 264 µM -1.62890038290725 0.0478186725043215 no 3192 0.0516670545178568 4544 15121435
SGTC_1426 4048-4480 71.7 µM -1.63387743281559 0.0473404569338554 no 3193 0.051142294576293 4563 14224343
SGTC_907 3448-6986 75.5 µM -1.63985001676371 0.0467716536916558 no 3194 0.0505181778133812 4573 590582
SGTC_2262 9014885 67.46 µM -1.63992746215061 0.0467643142923374 no 3195 0.0505101250369435 4602 6457424
SGTC_2751 anetholtrithion 17.25 µM -1.64111452939742 0.0466519330354904 no 3196 0.0503868216297605 4520 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1953 st076800 12.1 µM -1.64167728007251 0.0465987324391741 no 3197 0.050328451288219 4528 297591
SGTC_1895 st058434 18.3 µM -1.64415482104436 0.0463650926009888 no 3198 0.0500721132255975 4561 5393175
SGTC_3095 9117207 49.47 µM -1.64725658479108 0.0460739133706787 no 3199 0.0497526587745083 4578 17015229
SGTC_2794 7785382 27.27 µM -1.65227491819447 0.0456059279201827 no 3200 0.0492392599790429 4553 2205081
SGTC_1118 chelidonine 707.474 nM -1.65650134971006 0.0452147627881972 no 3201 0.048810165977222 4568 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3149 9097855 49.47 µM -1.6570031769084 0.045168497446553 no 3202 0.0487594163999566 4555 25236625 YMR079W SEC14
SGTC_1552 6-methylflavone 10.6 µM -1.65874532767297 0.0450081775888464 no 3203 0.048583560682754 4524 689013
SGTC_2754 granisetron 64.02 µM -1.66173773461262 0.0447338732682258 no 3204 0.0482826858048388 4560 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1148 3909-7663 27.7 µM -1.66220918124356 0.0446907802865392 no 3205 0.0482354198861152 4598 4084526
SGTC_925 2064-1272 59.6 µM -1.66576449438116 0.0443668795909503 no 3206 0.0478801652837164 4556 6815817
SGTC_2891 9063876 19.48 µM -1.66921204215975 0.0440546058905115 no 3207 0.047537682203848 4605 6472478
SGTC_158 k038-0087 26.446 µM -1.67075553852777 0.0439153738309819 no 3208 0.047384986938545 4486 X158
SGTC_1010 4112-3296 15.2 µM -1.6724248512121 0.0437651921390003 no 3209 0.0472202875310407 4598 704384
SGTC_1312 1218-2183 165 µM -1.67465954726327 0.0435647939826343 no 3210 0.04700052433215 4633 6744073
SGTC_1096 rimcazole 32.2 µM -1.67579968979834 0.0434628364672138 no 3211 0.0468887174639697 4534 18528119 A dopamine reuptake inhibitor.
SGTC_2094 5332512 191.667 µM -1.68021469144112 0.0430698396669393 no 3212 0.0464577759593679 4595 755774
SGTC_3354 9151612 71.43 µM -1.68468347903275 0.0426749835629987 no 3213 0.0460248278217171 4555 27261949
SGTC_609 0986-0026 86.3 µM -1.68623535808666 0.0425385481667317 no 3214 0.0458752380497153 4576 2848610
SGTC_199 4063-0024 41.6 µM -1.68689043061024 0.0424810626156608 no 3215 0.0458122112357713 4623 306215
SGTC_1531 st059297 52.4 µM -1.69561770770802 0.0417211828098279 no 3216 0.0449791510379305 4601 7566702
SGTC_1794 st048918 76.9 µM -1.69873013980752 0.0414528626922417 no 3217 0.0446850209083124 4571 672303
SGTC_2066 5222451 176 µM -1.69889475394399 0.0414387104736034 no 3218 0.0446695078246915 4530 2281147
SGTC_2918 7977171 22.06 µM -1.70038388477685 0.0413108646478751 no 3219 0.0445293705285982 4584 2236483
SGTC_2288 7946289 167.31 µM -1.70498381720209 0.0409179662228633 no 3220 0.0440987213081149 4592 1246052
SGTC_935 2996-0153 430 µM -1.70595709871086 0.0408352241632866 no 3221 0.0440080337509124 4591 23738523
SGTC_952 1185-0122 232 µM -1.71305217146294 0.0402361410457907 no 3222 0.043351470986427 4550 678600
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.71901792947072 0.0397379558900838 no 3223 0.0428055536281073 4619 1273210
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.7197935280978 0.0396735576116998 no 3224 0.0427349897311633 4596 688751
SGTC_865 0488-0499 301 µM -1.7226278689556 0.0394389424602443 no 3225 0.0424779209508338 4539 9634651
SGTC_2809 7964133 12.99 µM -1.72515270845131 0.0392308982835497 no 3226 0.0422499778818281 4585 1253665
SGTC_295 k015-0027 31 µM -1.74305156479996 0.0377815334485703 no 3227 0.0406623040153266 4651 3887424
SGTC_3252 9135871 49.47 µM -1.74378944625925 0.0377227340482163 no 3228 0.0405979057194676 4621 17682838
SGTC_2967 9089538 49.85 µM -1.74750802829089 0.0374275479430121 no 3229 0.040274626764007 4586 728216
SGTC_57 miconazole 162.5 nM -1.75364781911939 0.0369442940033327 no 3230 0.039745435920479 4459 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3086 9117350 49.47 µM -1.753695018305 0.036940598876941 no 3231 0.0397413898086291 4588 2679265
SGTC_1729 st035615 45.989 µM -1.75808970612259 0.0365978693896106 no 3232 0.0393661235017374 4596 17385451
SGTC_3230 9131665 49.47 µM -1.75832739231087 0.0365794073047726 no 3233 0.0393459097310888 4634 15943720
SGTC_3125 9127534 49.47 µM -1.76776485537705 0.0358524952952874 no 3234 0.038550111278482 4551 1639235
SGTC_1358 1509-0022 2.48 µM -1.77413903566898 0.0353682586362427 no 3235 0.038020077643505 4638 3258434
SGTC_2747 doxorubicin 7.63 µM -1.77967073642075 0.0349523831272242 no 3236 0.0375649311514509 4682 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1866 st057638 64 µM -1.78002192797482 0.0349261164755271 no 3237 0.0375361860661224 4630 688802
SGTC_2768 sulfasalazine 50.2 µM -1.78051301283662 0.0348894139626815 no 3238 0.0374960208117421 4591 5384001 An antioxidant and salicylic acid derivative.
SGTC_2219 9098279 200 µM -1.78441076305412 0.0345992269757963 no 3239 0.0371784717116446 4581 902349
SGTC_3118 9124250 49.47 µM -1.78444634461279 0.0345965870928861 no 3240 0.0371755830412544 4601 1504786
SGTC_2805 7950783 58.44 µM -1.78495454483642 0.0345589005277908 no 3241 0.0371343450824437 4608 1178958 YDL195W SEC31
SGTC_478 N-arachidonylglycine 10 µM -1.78556667639691 0.0345135515139651 no 3242 0.0370847232451648 4658 5283389
SGTC_1275 0867-0008 21.1 µM -1.78955031235875 0.0342196216776082 no 3243 0.0367631161907292 4609 3422836
SGTC_2946 9065502 71.43 µM -1.80055526309556 0.0334183082368081 no 3244 0.0358865029061024 4523 16489101
SGTC_2075 5212009 200 µM -1.80820840920528 0.0328702114131541 no 3245 0.0352870351639847 4585 780898
SGTC_2444 5485484 36.41 µM -1.80967342735726 0.0327661405600518 no 3246 0.0351732228231628 4653 6790631
SGTC_1039 k821-0043 94 µM -1.81340295439571 0.0325024308186881 no 3247 0.0348848471110456 4604 15992768
SGTC_1435 4092-0789 56.7 µM -1.81549859189753 0.0323550210668268 no 3248 0.0347236610808439 4646 2248285
SGTC_1445 4239-0156 97.7 µM -1.81883889739174 0.0321212005776505 no 3249 0.034468006059986 4660 4008346
SGTC_2115 tiliquinol 12.7705 µM -1.81955333051521 0.032071371972315 no 3250 0.0344135271497125 4600 71208 A bioactive hydroxyquinoline.
SGTC_154 3389-1638 511.116 µM -1.82213513782534 0.0318918339068311 no 3251 0.0342172416583903 4623 5238686
SGTC_3194 9111903 49.47 µM -1.82280422451363 0.0318454415168815 no 3252 0.0341665238412702 4614 17087251
SGTC_1938 st074717 56.4 µM -1.82438013149494 0.0317363932747324 no 3253 0.0340473118034143 4519 17250979
SGTC_39 0986-0283 58.349 µM -1.82448763047526 0.0317289659080804 no 3254 0.0340391923459512 4652 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1650 st011916 45.8 µM -1.82894328941062 0.031422374731731 no 3255 0.03370405214579 4618 242528
SGTC_373 0844-0104 25.9 µM -1.83731852896007 0.0308527086186165 no 3256 0.0330814430548412 4647 5375804
SGTC_3136 9095672 49.47 µM -1.84987121746747 0.0300149308542544 no 3257 0.0321660565982516 4513 17217380
SGTC_234 nsc-17383 10.7 µM -1.8543930465326 0.0297177993625769 no 3258 0.0318414744454034 4651 408974
SGTC_1022 4477-0945 21.3 µM -1.85607281710571 0.0296080444114848 no 3259 0.0317215898424951 4596 4648966
SGTC_2861 9024595 19.48 µM -1.85831988399256 0.0294617489713641 no 3260 0.0315618008930152 4618 16482810
SGTC_961 1252-1571 372 µM -1.86367470377203 0.0291155408202598 no 3261 0.031183699924053 4657 6813498
SGTC_1271 0832-2808 169 µM -1.86370993122821 0.0291132744796879 no 3262 0.0311812249925415 4664 3663794
SGTC_3064 1327-0027 10 µM -1.86961478604198 0.0287354545911689 no 3263 0.030768665245363 4639 16000455 YPR107C YTH1
SGTC_1106 tegaserod maleate 11.7 µM -1.87121582431459 0.0286337182297286 no 3264 0.0306575861359506 4667 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1877 wortmannin 25 µM -1.87201283770354 0.028583184605933 no 3265 0.0306024137315033 4647 312145 A covalent inhibitor of PI 3-kinase.
SGTC_505 gw-5074 63.9 µM -1.87375767659204 0.0284728142337256 no 3266 0.0304819161485136 4639 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3345 9148410 3.559 µM -1.88964839319761 0.027483868447645 no 3267 0.0294025001844124 4591 4903596
SGTC_3016 9080866 49.47 µM -1.89752536918098 0.0270043683143075 no 3268 0.028879316893196 4639 17066299
SGTC_811 0416-0114 265 µM -1.90320757264482 0.0266628239399428 no 3269 0.0285067327171339 4648 6612453
SGTC_1450 4112-4260 37.6 µM -1.90430325508772 0.0265973816440273 no 3270 0.028435350274059 4652 1633175
SGTC_489 paxilline 115 µM -1.92055143635109 0.0256425657648458 no 3271 0.0273941413118961 4622 105008 A toxic potassium channel blocker.
SGTC_2229 7354935 190 µM -1.92603752442315 0.0253267294959786 no 3272 0.0270498442806486 4663 318112
SGTC_466 geldanamycin 89.2 µM -1.9270597098544 0.0252682435297625 no 3273 0.0269860945479136 4698 5288382 HSP90 inhibitor.
SGTC_1950 st077106 7.18 µM -1.93751918459073 0.0246762650578601 no 3274 0.0263409552920314 4593 13831864
SGTC_1023 4482-3888 16 µM -1.94841939047024 0.0240717683604858 no 3275 0.0256824007567748 4665 3303168
SGTC_500 h-89 112 µM -1.95914197476788 0.0234893098640422 no 3276 0.0250480811346902 4650 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1553 gossypol 38.6 µM -1.98806205488736 0.0219771787715679 no 3277 0.0234024136594743 4658 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2995 9067767 71.4286 µM -1.99138063003968 0.0218090386091638 no 3278 0.0232195285546697 4666 11673567
SGTC_1306 1185-0270 9.02 µM -1.99201690134748 0.0217769254904312 no 3279 0.0231846017496282 4687 1548076
SGTC_1224 0823-0416 294 µM -2.00002685915573 0.0213760613198329 no 3280 0.0227486818353509 4698 3598164
SGTC_1388 3346-4487 254 µM -2.00913474404978 0.0209278484028204 no 3281 0.0222614229404881 4696 3345614
SGTC_2175 5807670 165.306 µM -2.00977016927922 0.0208968772210048 no 3282 0.0222277597032913 4664 241186
SGTC_483 fpl-64176 144 µM -2.01046354524233 0.0208631257450178 no 3283 0.0221910753983551 4760 3423
SGTC_218 alverine citrate 93.75 µM -2.03887552480664 0.0195192667327976 no 3284 0.0207312260955079 4724 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_766 1391-0721 126 µM -2.03940138390954 0.0194951038729518 no 3285 0.020704992207857 4697 1020919 YIL115C NUP159
SGTC_2102 5377816 72.7585 µM -2.04062181966994 0.0194391235890472 no 3286 0.0206442158264439 4702 1379702
SGTC_2107 5363541 170.161 µM -2.04480960642251 0.0192480707193347 no 3287 0.0204368161584433 4649 244052
SGTC_1907 st060210 83.7 µM -2.05800720245239 0.0186563844773816 no 3288 0.0197947210079502 4684 688793
SGTC_1008 4106-0037 6 µM -2.07145573826365 0.0180694456453631 no 3289 0.0191581133448719 4718 2905394
SGTC_475 α-linolenic acid 10 µM -2.08041917417755 0.0176870551100158 no 3290 0.0187435510345739 4702 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1923 st058458 19.1 µM -2.08746253016251 0.0173914424034768 no 3291 0.0184231723527739 4684 3534982
SGTC_2493 resveratrol 26.09 µM -2.08808674946483 0.0173654483801374 no 3292 0.018395005050802 4686 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1079 idarubicin 2.36 µM -2.09109468588212 0.0172406552247835 no 3293 0.0182597884965018 4723 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_780 0109-0199 192 µM -2.12547745924648 0.0158677737167737 no 3294 0.016773396481066 4716 610414
SGTC_2380 9035439 200 µM -2.12765352841193 0.0157841312153453 no 3295 0.0166829102989684 4729 6462575
SGTC_1029 k015-0030 64.7 µM -2.15858878685396 0.0146353535665047 no 3296 0.0154410417270683 4726 2208316
SGTC_1908 st060353 56.5 µM -2.16561242228911 0.0143847903549308 no 3297 0.0151704081642744 4708 4227716
SGTC_2327 6189656 200 µM -2.16941889032157 0.0142505470984029 no 3298 0.0150254480469264 4733 5349088
SGTC_26 0302-0163 425.158 µM -2.17588635161841 0.0140249321295298 no 3299 0.014781879800772 4747 3100915
SGTC_3308 9128332 17.569 µM -2.18955427687767 0.0135582413819171 no 3300 0.014278289054634 4698 17332805 YDL196W YDL196W
SGTC_1935 st074532 41.6 µM -2.20195061528222 0.0131466216683384 no 3301 0.0138343985371494 4701 2829742
SGTC_896 0964-0007 44.5 µM -2.20252070764781 0.0131279543642455 no 3302 0.0138142740174487 4702 6756758
SGTC_61 0978-8327 98.565 µM -2.20383298512361 0.0130850717227098 no 3303 0.0137680459528295 4684 6150059 YHR072W ERG7
SGTC_1762 st045503 25.4615 µM -2.25296133301129 0.0115644463971735 no 3304 0.0121307935519203 4729 4645554
SGTC_56 0957-0365 83.25 µM -2.25566208727539 0.0114854960755827 no 3305 0.0120459008240696 4677 6752360
SGTC_816 0325-0417 81.3 µM -2.28046741799901 0.0107820005103825 no 3306 0.0112899905356936 4740 68101
SGTC_1296 1068-0102 11.9 µM -2.29724188131031 0.0103278008548226 no 3307 0.0108024875926795 4748 767053
SGTC_1400 3771-8998 51.5 µM -2.29801584083962 0.0103072532076462 no 3308 0.010780443779822 4739 670767
SGTC_1169 aniline yellow 25.8 µM -2.32230120690521 0.00968036220564206 no 3309 0.0101083613068901 4725 6051 A DNA damaging agent.
SGTC_2639 lactacystin 53 µM -2.33163345229988 0.0094484763918702 no 3310 0.009859991215133 4738 3870 A proteasome inhibitor.
SGTC_2647 atorvastatin 60.16 µM -2.34750683939907 0.00906520424634399 no 3311 0.00944976308635354 4753 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_84 0443-0269 128.823 µM -2.35742556205848 0.0088326837029806 no 3312 0.00920107215949389 4732 6150058
SGTC_822 1487-0950 154 µM -2.36992779920998 0.00854705737961161 no 3313 0.00889577961040609 4729 1958375
SGTC_676 falcarinol 140 µM -2.39278940549239 0.00804566499704428 no 3314 0.00836041770080975 4743 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_459 nigericin 15.3 µM -2.42937859617376 0.00729692161806806 no 3315 0.00756236467842753 4762 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2983 9022671 12.99 µM -2.45542397921483 0.00680204951064156 no 3316 0.00703592562083603 4751 6405161
SGTC_2670 beta-carotene 100 µM -2.46267168886104 0.0066697221636602 no 3317 0.00689530647041949 4781 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2504 purpurogallin 52.29 µM -2.47092280626711 0.0065218489826093 no 3318 0.00673824528042217 4726 5281571 An antioxidant.
SGTC_2435 5706476 10.6 µM -2.47418318985037 0.00646422172398296 no 3319 0.00667706011906804 4752 5725375
SGTC_564 3555-0129 330 µM -2.49389432962648 0.00612532580544997 no 3320 0.00631750765154423 4757 563260
SGTC_156 3474-0145 5.642 µM -2.5048044696398 0.00594459578134069 no 3321 0.0061259551960904 4722 2265471
SGTC_581 0958-0271 211 µM -2.51965067158842 0.00570626364560835 no 3322 0.00587356761897794 4770 4591145
SGTC_1456 k015-0012 13 µM -2.54669074210655 0.00529388810707348 no 3323 0.00543748805776951 4762 2989616
SGTC_1717 st033143 58.0435 µM -2.58336069060747 0.00477705734310325 no 3324 0.00489214862048121 4747 674616
SGTC_1835 st008666 49.2 µM -2.59382031039246 0.00463812911757032 no 3325 0.00474580397119177 4754 690455
SGTC_1974 st069448 26.9 µM -2.61271057356426 0.00439633153116815 no 3326 0.00449136684175048 4769 6323587 YNR016C ACC1
SGTC_2346 9031566 143.75 µM -2.64072935690192 0.00405840979598224 no 3327 0.00413638879699585 4765 4771086
SGTC_3218 9131285 49.47 µM -2.65843315583169 0.00385706790454419 no 3328 0.0039252461003134 4742 17156417
SGTC_1499 4480-0877 67.3 µM -2.66447200522883 0.00379046509368607 no 3329 0.00385546420708936 4791 2861909
SGTC_2994 9053520 71.4286 µM -2.67920658439464 0.00363226365222323 no 3330 0.00368984243233811 4758 4647384
SGTC_1882 5615643 20 µM -2.81289164813608 0.00244606312042674 no 3331 0.00245490961087157 4788 2253075
SGTC_1862 st057513 3.81 µM -2.83703665110637 0.00227372605195372 no 3332 0.00227671923353023 4781 5393163
SGTC_2119 5528445 120.635 µM -2.8384638883798 0.00226389193469972 no 3333 0.00226656242119237 4783 791935
SGTC_3204 9114183 49.47 µM -2.86066215273468 0.00211581905705628 no 3334 0.0021137864933952 4745 17027248
SGTC_2057 5236571 38.335 µM -2.87447410401334 0.00202817747242545 no 3335 0.00202350478053209 4757 54684039 YBR257W POP4
SGTC_1636 st007707 68.9 µM -2.91301711522086 0.00180075741320634 no 3336 0.00178977490789343 4788 403051
SGTC_456 gingerol 170 µM -2.94866121971646 0.0016113480326565 no 3337 0.00159576812504273 4779 442793 A herb.
SGTC_2505 galangin 7.89 µM -2.97934487778898 0.00146303685959707 no 3338 0.00144432725000953 4781 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2108 5365811 200 µM -2.98959997011775 0.0014163171988518 no 3339 0.00139671510081256 4797 780283
SGTC_2296 7971656 126.45 µM -3.08567011048524 0.00104035734067707 no 3340 0.00101547006447719 4780 666570
SGTC_3139 9095020 49.47 µM -3.19022219323119 0.000736864274431273 yes 3341 0.000710817236078324 4782 25236292
SGTC_950 1165-0508 94.1 µM -3.253601495831 0.000595049167109553 yes 3342 0.000569760050826751 4778 6148369
SGTC_807 1315-0151 48 µM -3.2729228958668 0.000557117366603085 yes 3343 0.000532207547683188 4789 4011080
SGTC_797 k781-0471 270 µM -3.28765668412373 0.000529708294858142 yes 3344 0.000505124774471741 4796 23738129
SGTC_2588 indole-3-carbinol 100 µM -3.30754929589458 0.000494679212891025 yes 3345 0.000470580728677576 4793 3712 Induces cell cycle arrest.
SGTC_2910 7948405 25.97 µM -3.33392780337565 0.000451532629734596 yes 3346 0.000428144402379391 4795 2971328
SGTC_2915 7971052 15.16 µM -3.39581635880797 0.00036362458614628 yes 3347 0.000342121252309228 4801 5741558
SGTC_803 4488-1585 147 µM -3.40250280623959 0.000355144980718344 yes 3348 0.000333858347649114 4801 747204
SGTC_2848 9016370 25.97 µM -3.4621572511637 0.000287223854816859 yes 3349 0.000267931981991779 4783 7894410
SGTC_945 3381-0768 11.3 µM -3.47234398592892 0.00027691221100246 yes 3350 0.00025796739671056 4797 1126236 YIL048W NEO1
SGTC_1618 st003135 44.5 µM -3.48439077010267 0.000265162992332439 yes 3351 0.000246629375332462 4793 1270615
SGTC_2123 5259487 200 µM -4.32056479465892 9.53650939184012e-06 yes 3352 7.78151741683119e-06 4809 2173474
SGTC_2298 7976326 193.81 µM -5.19601319952869 1.49506898600151e-07 yes 3353 1.01803904102666e-07 4809 2235818