SGTCid condition conc unit TAT2|YOL020W.score TAT2|YOL020W.strain.pval TAT2|YOL020W.strain.significant TAT2|YOL020W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_704 1310-0270 142 µM 5.63715482881341 4.15373788433398e-08 yes 1 8.64413329739786e-09 9 5718033 SGTC_2908 7930301 100 µM 5.27612215989782 2.64845371991578e-07 yes 2 6.59730743515283e-08 7 2223178 SGTC_1221 2958-7315 257 µM 5.11656422992603 5.78908612384042e-07 yes 3 1.55575679790862e-07 5 4562705 SGTC_2952 9073731 13.78 µM 5.06807721312809 7.30938193079972e-07 yes 4 2.0092720026266e-07 13 16457353 SGTC_2054 5233173 129 µM 5.01048040926905 9.61630320395073e-07 yes 5 2.71471627951649e-07 26 6889 SGTC_1255 0566-0045 221 µM 4.90563531389945 1.57253691274233e-06 yes 6 4.65627064888279e-07 12 2788469 SGTC_3225 9130819 49.47 µM 4.77053148577031 2.92174735104753e-06 yes 7 9.18702305222935e-07 12 4547121 SGTC_1196 1588-0294 184 µM 4.70371925975715 3.94562816895305e-06 yes 8 1.27732233790332e-06 6 6144269 SGTC_2352 9027995 87.8 µM 4.60252784855001 6.17286644497113e-06 yes 9 2.0869686558958e-06 23 2997347 SGTC_2302 7771753 200 µM 4.48653248839037 1.01976231796255e-05 yes 10 3.61958414801422e-06 29 2203047 SGTC_1262 0737-0114 49.6 µM 4.48607860505378 1.02174372971957e-05 yes 11 3.627299316913e-06 10 765919 SGTC_3210 9128157 49.47 µM 4.4640977557853 1.12221089351165e-05 yes 12 4.02034250247649e-06 35 17590849 SGTC_982 1491-0518 27.5 µM 4.46032837852923 1.14035754502932e-05 yes 13 4.09170841186642e-06 6 3091256 SGTC_163 TUB2.036 7.546 µM 4.45215412748138 1.18067439278894e-05 yes 14 4.25065537350333e-06 83 15992207 YJR013W GPI14 SGTC_849 0386-0493 241 µM 4.39877157404897 1.47926785273079e-05 yes 15 5.44326683405381e-06 9 726119 SGTC_1096 rimcazole 32.2 µM 4.35949675369935 1.74339570357277e-05 yes 16 6.5180943792296e-06 2 18528119 A dopamine reuptake inhibitor. SGTC_3271 9137798 49.47 µM 4.28622763059896 2.36014221040607e-05 yes 17 9.08663872567842e-06 3 6498326 SGTC_2521 angolensin 13.4 µM 4.28225323603422 2.39891776409807e-05 yes 18 9.25051272363787e-06 8 821428 A flavenoid. SGTC_3082 9117008 49.47 µM 4.26578490385082 2.56611850756658e-05 yes 19 9.96003146316489e-06 12 41448529 SGTC_1378 2093-0007 380 nM 4.22968527218139 2.97207833113308e-05 yes 20 1.17009239803606e-05 17 3618014 SGTC_8 0354-0001 70 µM 4.2275233169592 2.99822695366927e-05 yes 21 1.18138848169817e-05 69 4993152 SGTC_676 falcarinol 140 µM 4.19298046872202 3.4467319732552e-05 yes 22 1.37656577676265e-05 47 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1842 st055362 61.2 µM 4.1797769144145 3.63437794912168e-05 yes 23 1.4589760211231e-05 11 676032 SGTC_1936 st074407 74.3 µM 4.16130282056592 3.91320059432851e-05 yes 24 1.58218575593546e-05 31 809813 SGTC_851 0394-0702 453 µM 4.11037221691967 4.79032879171771e-05 yes 25 1.97510918086293e-05 11 762646 SGTC_1328 1441-0025 69.2 µM 4.10397481619097 4.9127969579912e-05 yes 26 2.03055845462975e-05 5 4562601 SGTC_821 1114-0266 29.2 µM 4.07805974553661 5.43979483950035e-05 yes 27 2.27065490308533e-05 18 3123235 SGTC_826 1683-5028 118 µM 4.04275352246763 6.24403345439894e-05 yes 28 2.64135721368103e-05 13 722377 SGTC_2455 5377712 9.75 µM 3.92554473603437 9.79251416114742e-05 yes 29 4.32668425953363e-05 22 2243908 SGTC_3324 9138759 60.749 µM 3.92540588532567 9.79766655849927e-05 yes 30 4.32918091687748e-05 20 45595710 SGTC_980 1473-0395 201 µM 3.8138032349363 0.000148728961790852 yes 31 6.84222175384905e-05 13 768876 SGTC_720 r052-1644 49.9 µM 3.76365833702868 0.000178781247553244 yes 32 8.3722811160788e-05 29 1422863 YOR257W CDC31 SGTC_150 3970-0969 77.2 µM 3.75973958411319 0.000181354518543756 yes 33 8.50451593594644e-05 71 6615640 SGTC_168 3970-0862 530.542 µM 3.75654335291814 0.000183478941316869 yes 34 8.6138219299352e-05 131 3135186 SGTC_2130 NSC 7 2.4545 µM 3.75392319001273 0.000185237802849637 yes 35 8.70441146609632e-05 31 21448 SGTC_1295 1013-0063 9.78 µM 3.68886007271687 0.000234310895711314 yes 36 0.000112630529241162 18 6826038 SGTC_170 4197-0004 226 µM 3.66083740312249 0.000258977945395502 yes 37 0.00012569613190139 24 218692 SGTC_862 0452-0056 10.2 µM 3.65699265937714 0.000262545178251912 yes 38 0.000127595842821214 38 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1299 1079-1439 3.74 µM 3.60255658103733 0.00031822261351416 yes 39 0.000157551391964842 17 323161 SGTC_1099 5-nonyloxytryptamine 2.85 µM 3.59792865896692 0.000323430590241614 yes 40 0.000160380784196523 30 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3197 9113331 49.47 µM 3.52665326365488 0.000414334259316612 yes 41 0.000210423755225186 47 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.48477604080189 0.000478265827422943 yes 42 0.000246274558297548 38 6312947 SGTC_2737 bleomycin 30.5 nM 3.48322777139497 0.000480796004613606 yes 43 0.00024770333841135 110 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_928 2764-0428 58.7 µM 3.43422956794494 0.00056756988676768 yes 44 0.000297120346217555 82 662578 SGTC_31 0508-1974 57.237 µM 3.42246326878178 0.000590459817169242 yes 45 0.000310282408701317 44 6810525 SGTC_2365 9042475 200 µM 3.39064222160554 0.000656705017697466 yes 46 0.000348645323306 67 6464479 SGTC_1768 st044301 37.178 µM 3.38554254043821 0.000667938129278175 yes 47 0.000355188489209968 34 3931349 SGTC_2942 9052777 62.25 µM 3.36881323007008 0.000706044411755227 yes 48 0.00037746282465269 59 6469503 SGTC_2435 5706476 10.6 µM 3.34764112622419 0.000757143224118776 yes 49 0.000407512392008892 42 5725375 SGTC_2261 9010538 184.68 µM 3.31151744503592 0.000852256833797519 yes 50 0.000463957271370266 32 6457250 SGTC_1421 4029-0249 71.4 µM 3.30128676245099 0.000881125207739343 yes 51 0.000481212305367838 36 2894095 SGTC_295 k015-0027 31 µM 3.28226149506404 0.000937212490377617 yes 52 0.000514890297769382 24 3887424 SGTC_56 0957-0365 83.25 µM 3.20236267052966 0.00121039721633262 no 53 0.000681526368208047 80 6752360 SGTC_303 1348-1668 34.2 µM 3.20054333626849 0.00121739080830299 no 54 0.000685843701847084 13 5380509 SGTC_272 doxorubicin 8.13 µM 3.1960265997881 0.00123491348628693 no 55 0.000696671329003457 59 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2749 bexarotene 57.39 µM 3.15550361940105 0.00140275896196292 no 56 0.000801106391850389 57 82146 An retinoic acid receptor inhibitor. SGTC_2789 5281112 71.43 µM 3.10549922867469 0.00163849478713548 no 57 0.000949790581135602 79 765948 SGTC_265 mycophenolic acid 32.932 µM 3.09112166762992 0.00171266232936594 no 58 0.000997009551497758 61 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3190 9110366 49.47 µM 3.08415482984564 0.00174968930230083 no 59 0.00102065665084793 37 17123768 SGTC_1301 naphtanilide LB 4.81 µM 3.07929349911495 0.00177595594834705 no 60 0.00103746079300584 35 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1506 4226-2149 212 µM 3.04106510511802 0.00199534460714052 no 61 0.00117871425164386 78 991114 SGTC_1812 st052057 4.327 µM 3.0339730281796 0.00203865373489528 no 62 0.00120678003563669 71 3645418 SGTC_1419 3993-2473 62.6 µM 3.02594997339121 0.00208867529364825 no 63 0.00123926653452414 49 704026 SGTC_1529 apigenin 74 µM 2.99667079566644 0.00228081084634561 no 64 0.00136472646028453 81 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2748 diazoxide 86.69 µM 2.995998257005 0.00228540643361429 no 65 0.00136773998657837 33 3019 A potassium channel activatior. SGTC_2718 lomofungin 53.02 µM 2.95594790186105 0.00257467653492483 no 66 0.00155854869177413 46 5351222 A RNA synthesis inhibitor. SGTC_3020 9089140 49.47 µM 2.94583586572563 0.00265276098003499 no 67 0.00161041630333757 74 17217859 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.93586119397129 0.00273187386857345 no 68 0.00166311561905351 37 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3244 9134489 49.47 µM 2.9086893316151 0.00295830041960341 no 69 0.001814736663436 70 16584271 SGTC_691 1548-0686 185 µM 2.90801195173539 0.00296415512717759 no 70 0.00181867217989048 105 46495133 SGTC_1559 coumarin 343 70.1 µM 2.89134963492803 0.00311149754734615 no 71 0.00191795551966462 47 108770 A hepatotoxic, DNA x-linker. SGTC_1770 st043884 66.3 µM 2.88563800589253 0.00316350225918398 no 72 0.00195310580480612 59 670149 SGTC_2651 TUB2.036 5 µM 2.87791083514851 0.00323510348607668 no 73 0.00200159135401467 256 15992207 YFL037W TUB2 SGTC_3112 9123419 49.47 µM 2.87522614479237 0.00326031945081271 no 74 0.00201869105863048 69 17015854 SGTC_880 0833-0487 87.2 µM 2.86681786985445 0.0033404420953364 no 75 0.00207310773896455 58 76075 SGTC_2788 5282734 71.43 µM 2.83449324997247 0.00366520433488318 no 76 0.00229492137828504 126 743706 SGTC_305 1682-2595 20.8 µM 2.8332312111886 0.00367843985591258 no 77 0.00230400214053324 67 226033 SGTC_87 0100-0052 35.5 µM 2.82935789487038 0.00371932907449177 no 78 0.0023320754077386 254 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.82200566446642 0.00379806684801752 no 79 0.00238621671557106 59 1609 A potent and irreversible inhibitor of serine proteases. SGTC_268 camptothecin 39.6153 µM 2.81488556383341 0.0038757395985146 no 80 0.00243973029442926 169 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3078 9116413 49.47 µM 2.80402459816046 0.00399696448770234 no 81 0.00252345272501077 92 17177322 SGTC_2020 4017018 200 µM 2.80252469559357 0.00401396982617179 no 82 0.0025352167149602 83 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_84 0443-0269 128.823 µM 2.7937900085704 0.00411429372907863 no 83 0.0026047147365647 77 6150058 SGTC_2151 5563267 85.4165 µM 2.78649467013485 0.00419979910414169 no 84 0.00266407471458207 85 5310824 SGTC_2864 9034755 47.6 µM 2.78342088861219 0.0042362989494625 no 85 0.00268944891836632 63 4930451 SGTC_2665 lovastatin 100 µM 2.78265781185776 0.00424540399984027 no 86 0.00269578186885666 68 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1899 st063254 59.6 µM 2.77047691943593 0.00439313484484249 no 87 0.00279871335511384 55 3093813 SGTC_1519 esterone 74 µM 2.76998393074837 0.00439920940219508 no 88 0.002802952914977 79 698 A steroid. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.72682540315553 0.00496098745065554 no 89 0.00319734328317923 65 17037758 SGTC_1764 st044502 93.5 µM 2.71477012963891 0.00512892453354055 no 90 0.00331608936817958 114 8407 SGTC_1481 3346-2004 36 µM 2.70369854469437 0.00528759650116215 no 91 0.00342862340113281 60 2770522 SGTC_1830 st055982 50.3 µM 2.69991352384868 0.00534283438713087 no 92 0.00346787507058788 82 455313 An antimicrobial agent. SGTC_1832 st054113 55 µM 2.69875820515443 0.0053597968019517 no 93 0.00347993618113673 47 1251267 SGTC_2874 9043904 71.43 µM 2.68697799210166 0.00553550645270547 no 94 0.00360508516003017 69 4463428 SGTC_1303 1160-0052 261 µM 2.68140714632085 0.00562036744929514 no 95 0.00366566285667264 72 3562476 SGTC_978 1416-0512 87.4 µM 2.66704371994923 0.0058445186014287 no 96 0.00382608583323989 105 6814003 SGTC_1000 4048-0884 8.67 µM 2.63942685719341 0.00629788316734996 no 97 0.00415231707838583 105 13040088 SGTC_2157 5649910 96.377 µM 2.63022711960451 0.00645567641806311 no 98 0.00426639206759976 107 2858091 SGTC_3108 9121785 49.47 µM 2.62558233389671 0.006536664386333 no 99 0.0043250443016434 82 17140271 SGTC_178 4092-0806 87.505 µM 2.61753428996489 0.00667912172404229 no 100 0.00442837946051473 215 2169044 SGTC_2386 9075165 157.42 µM 2.6157308981067 0.00671141716446651 no 101 0.0044518349305008 55 16452277 SGTC_2537 larixol 68.93 µM 2.60738703227418 0.00686264362584388 no 102 0.00456180851026123 118 6708759 SGTC_752 1896-0090 130 µM 2.60663623087804 0.00687639781660577 no 103 0.00457182214805835 85 772567 SGTC_81 0411-0046 9.971 µM 2.59107991058322 0.0071669094689636 no 104 0.00478376361436826 97 12925265 SGTC_1319 1306-0155 43.7 µM 2.58428179364586 0.00729722631790937 no 105 0.00487910149984573 136 3122360 SGTC_322 k048-0136 19.3 µM 2.57708705611811 0.00743741733703198 no 106 0.00498184265441453 80 6823282 SGTC_101 0490-5701 117.494 µM 2.57206113509068 0.00753675121416882 no 107 0.0050547519038212 89 4661669 SGTC_379 3970-0972 5.9 µM 2.57154419302795 0.00754703419698277 no 108 0.00506230462456479 127 2898042 YBL034C STU1 SGTC_2735 sertaconazole 140 nM 2.57040766535312 0.00756968539993697 no 109 0.00507894506907538 50 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3315 9136395 68.55 µM 2.56671236806021 0.00764374767291054 no 110 0.00513338678300428 89 16876844 SGTC_2310 7668677 200 µM 2.55302092825142 0.00792374573511594 no 111 0.00533965395805767 134 2197143 SGTC_673 1082-0474 110 µM 2.54733657381735 0.00804261893074626 no 112 0.00542743415157085 192 3098046 SGTC_2522 biochanin a 4.94 µM 2.52118494717809 0.00860993465868313 no 113 0.00584801799383758 86 5280373 A possible chelator. SGTC_1721 st082152 9.2685 µM 2.51957268961618 0.00864603134354284 no 114 0.00587486885894724 106 5296051 SGTC_1663 st014140 55.4 µM 2.50773547843835 0.00891514209871141 no 115 0.00607537952215228 117 4207120 SGTC_2004 4023728 41.89 µM 2.49156921457322 0.00929451331004492 no 116 0.00635900923572208 137 360084 YDR527W RBA50 SGTC_1486 3970-0793 4.53 µM 2.48252238461806 0.00951291875036241 no 117 0.00652279355557719 71 2844330 SGTC_600 1495-0418 41.6 µM 2.47574816202167 0.0096793849420562 no 118 0.00664786627807287 96 5377768 SGTC_585 0kpi-0023 191 µM 2.47483030651552 0.0097021345216122 no 119 0.00666497474063286 108 64601 SGTC_2603 homopterocarpin 100 µM 2.47432601765233 0.00971465348708619 no 120 0.00667439104059508 167 101795 A weak amylase inhibitor. SGTC_957 1187-1561 14.1 µM 2.46826472682004 0.00986623282662477 no 121 0.00678849351485256 133 1538454 SGTC_2953 9074162 66.49 µM 2.45634973103489 0.010170230213725 no 122 0.00701782443033403 109 16451992 SGTC_1984 st072354 53.1 µM 2.45351771196084 0.0102436765543192 no 123 0.00707332862226136 99 5762938 SGTC_2517 totarol 10 µM 2.45322132824841 0.0102513897226366 no 124 0.00707915972087861 113 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1772 st048439 82.2 µM 2.437397637305 0.0106706117624344 no 125 0.00739670096289105 143 2927068 YDL195W SEC31 SGTC_1097 itavastatin 7.23 µM 2.43571733889032 0.010715993402304 no 126 0.0074311466065546 139 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2093 5331342 194.4 µM 2.41591420606086 0.0112636303142346 no 127 0.00784787956347319 119 33839 SGTC_3162 9099653 49.47 µM 2.41076070184758 0.0114100741489064 no 128 0.00795964475473797 81 25237511 SGTC_3293 9120939 62.045 µM 2.40614467084158 0.0115426465264146 no 129 0.00806093945402071 124 934087 SGTC_681 1642-0006 26.6 µM 2.40431390165981 0.0115955955187504 no 130 0.00810142680690069 63 4446530 SGTC_3158 9100007 49.47 µM 2.39913529604757 0.0117465132481735 no 131 0.00821692066856098 102 19297233 SGTC_339 3091-4833 71.4 µM 2.38915833746684 0.0120420780898663 no 132 0.00844351133850027 110 3240077 SGTC_46 0329-0187a 2.197 µM 2.38709113264152 0.0121041186142856 no 133 0.00849114049365288 220 46494817 SGTC_2857 9024691 58.44 µM 2.35861243013829 0.0129874320624997 no 134 0.00917170114776168 139 16478292 SGTC_2905 7799065 20.05 µM 2.35519467515711 0.0130970957342453 no 135 0.00925650200755073 103 1296806 SGTC_1190 1486-1332 13 µM 2.35411380296787 0.0131319432632372 no 136 0.00928346288878037 131 4150046 SGTC_2502 avocadyne acetate 18.59 µM 2.35015605997065 0.0132602263834507 no 137 0.00938277070177104 176 3952079 SGTC_655 k060-0012 42 µM 2.34920483425163 0.0132912195311709 no 138 0.00940677694471012 123 5994525 SGTC_1699 st031318 29.054 µM 2.34620588113327 0.0133893423623084 no 139 0.00948281405241807 123 5340658 SGTC_1200 1643-0193 18.4 µM 2.33802064060289 0.0136603452022684 no 140 0.00969308871666528 143 5403974 SGTC_2890 9046729 58.44 µM 2.33529939702198 0.0137514842995231 no 141 0.00976389282843286 122 903329 SGTC_3314 9135860 59.4275 µM 2.33435169296321 0.0137833474384464 no 142 0.00978865702070566 119 25252478 SGTC_1309 pyrazolanthrone 13.4 µM 2.32884274945514 0.0139698296262778 no 143 0.00993369888479212 134 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1457 k015-0032 57.3 µM 2.32512140844217 0.0140970273845587 no 144 0.0100327346040869 176 4302660 SGTC_2174 5790901 200 µM 2.32128581283391 0.0142291736743659 no 145 0.0101357117072703 170 786020 SGTC_1851 st056236 18.9 µM 2.31960612596249 0.0142873784112466 no 146 0.0101810970816416 136 5393171 SGTC_582 0987-0078 156 µM 2.31258269861569 0.0145329818359266 no 147 0.0103727968376988 259 1625765 SGTC_1806 st050005 60.3 µM 2.31081233211221 0.0145954604789484 no 148 0.010421611523252 141 5194765 SGTC_1445 4239-0156 97.7 µM 2.30738028807106 0.0147172405659135 no 149 0.0105168145753601 160 4008346 SGTC_98 0074-0023 107.663 µM 2.30236507261888 0.0148967681369207 no 150 0.0106572964692014 176 3563821 SGTC_2704 st078022 71.1 µM 2.30081816374145 0.0149525207749711 no 151 0.0107009556615766 135 54697681 SGTC_1194 1488-0194 225 µM 2.28843847041986 0.0154051980352192 no 152 0.0110559997308381 176 1391452 SGTC_2442 5158906 48.48 µM 2.28314308794562 0.0156023935376445 no 153 0.0112109705984584 144 1893835 SGTC_772 k072-0172 35.3 µM 2.28040762591203 0.0157051055617281 no 154 0.0112917618771581 145 5861980 SGTC_2556 citropten 84.59 µM 2.27966352713139 0.015733145379134 no 155 0.0113138260299123 190 2775 A potential DNA crosslinker. SGTC_2661 dactinomycin 12.96 µM 2.27278586602086 0.0159943547731236 no 156 0.0115195435963207 159 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1365 1672-3266 55.4 µM 2.27007183100516 0.0160984503948001 no 157 0.0116016125652816 149 6415873 SGTC_3010 9080089 71.4286 µM 2.25331419517487 0.0167541258190033 no 158 0.0121196726754479 145 17027233 SGTC_2497 7-hydroxyflavone 100 µM 2.24898494926549 0.0169271833981237 no 159 0.0122567268244689 151 5281894 SGTC_2383 9036125 200 µM 2.24510418202586 0.0170836103419292 no 160 0.0123807226032544 89 79580 SGTC_302 1094-0063 18.9 µM 2.24224346155599 0.0171997105621014 no 161 0.0124728208141776 117 5440289 SGTC_800 3448-7362 155 µM 2.23756086384971 0.0173912051509163 no 162 0.0126248530518101 439 15991913 SGTC_1316 1272-0050 65.9 µM 2.23456070064893 0.0175148512607934 no 163 0.0127231016538864 128 7340392 SGTC_2070 5230947 200 µM 2.23171421728124 0.0176328567773735 no 164 0.0128169284945397 139 2835538 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.22512394299121 0.017908673719977 no 165 0.0130364594158179 116 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2728 chlorpromazine 9.18 µM 2.21861898177493 0.0181845200395516 no 166 0.0132563285310881 88 2726 A thorazine and dopamine antagonist. SGTC_5 0352-0601 109.883 µM 2.21702604539404 0.0182526186306895 no 167 0.0133106558875695 111 762456 SGTC_1034 k072-0165 12.7 µM 2.21293355528537 0.0184285710301762 no 168 0.01345111344026 179 5835461 SGTC_210 3551-0445 56.827 µM 2.21272689022577 0.0184374945682515 no 169 0.0134582401673085 188 2865180 YOR207C RET1 SGTC_2480 5767542 37.17 µM 2.20316477127375 0.0188544181968868 no 170 0.013791568658237 134 2867358 SGTC_2714 st079313 56.9 µM 2.19696202072173 0.0191291353633433 no 171 0.0140115793754903 144 2939799 SGTC_964 1287-0107 19.4 µM 2.19252833923107 0.0193275804287227 no 172 0.0141706895597127 204 51516812 YPR165W RHO1 SGTC_128 0906-2981 13.371 µM 2.19193074391668 0.0193544612350814 no 173 0.0141922538805323 128 6740226 SGTC_2871 9038510 12.99 µM 2.19126444664828 0.0193844698150916 no 174 0.014216330649858 159 4945164 SGTC_1058 3448-5425 97.3 µM 2.18461757464006 0.0196860007254278 no 175 0.0144584491202788 184 7279705 SGTC_742 0kpi-0133 140 µM 2.18065931394148 0.019867449395789 no 176 0.0146043122369614 173 2728852 SGTC_1619 st003326 88.7 µM 2.17924357568146 0.0199326912262036 no 177 0.0146567891878148 139 2849032 SGTC_2970 9090938 41.86 µM 2.17092357644598 0.0203197879815033 no 178 0.0149684749127852 258 17217104 SGTC_1350 1495-0454 146 µM 2.16009575240476 0.0208330906933254 no 179 0.0153826288926235 213 1069057 SGTC_2345 9052315 157.45 µM 2.14697533035499 0.0214697462225003 no 180 0.0158976228282758 197 6469265 SGTC_1970 st070122 35.8 µM 2.14066046821127 0.0217819844897386 no 181 0.0161507143207292 193 102928 SGTC_670 4204-0025 119 µM 2.14065829121588 0.0217820927891087 no 182 0.0161508021637283 203 719039 SGTC_1696 st025591 34.7925 µM 2.14024138869306 0.0218028408970176 no 183 0.0161676319644975 206 2787147 SGTC_1212 0520-0165 585 µM 2.13357999977191 0.022136630906647 no 184 0.0164385883020039 200 5403258 SGTC_2721 ifenprodil 61.44 µM 2.12202261134838 0.0227259826371233 no 185 0.016917919647768 186 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3186 9110464 49.47 µM 2.1210222867241 0.0227776087927034 no 186 0.0169599634805804 158 17018021 SGTC_2303 7774051 200 µM 2.10496124886922 0.0236201339344979 no 187 0.0176473406901047 192 2953184 SGTC_3103 9120822 49.47 µM 2.10222150153155 0.0237664400406819 no 188 0.0177669385782505 184 17141819 SGTC_177 1327-0068 8.361 µM 2.09651272646101 0.0240737449608767 no 189 0.0180183660864231 241 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1814 st052110 31.539 µM 2.08580806149519 0.0246589814067757 no 190 0.0184980064487559 165 674163 SGTC_2318 6029776 164 µM 2.08369029436838 0.0247761654585994 no 191 0.0185941738172424 220 818325 SGTC_679 0422-0091 41.4 µM 2.08211721370569 0.0248635119963829 no 192 0.0186658822941453 233 627384 YHR062C RPP1 SGTC_2702 st077768 96.8 µM 2.07916548251406 0.0250281061456953 no 193 0.0188010715358757 180 6484119 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.07645373150157 0.0251801226548659 no 194 0.0189260030795921 263 688664 SGTC_969 1313-0238 134 µM 2.07357064084871 0.0253425920880846 no 195 0.0190596021050203 242 5212874 SGTC_1005 4092-0690 4.4 µM 2.06564471199775 0.025793769570492 no 196 0.0194310196510189 197 1529343 SGTC_1670 st016595 4.04 µM 2.06372925648519 0.0259038083149187 no 197 0.0195216969041291 189 597879 SGTC_2868 9035608 32.47 µM 2.06302144917735 0.0259445695621762 no 198 0.0195552951716594 194 6462614 SGTC_1127 asiatic acid 681.4 nM 2.05685161749654 0.0263021557378351 no 199 0.0198502505799793 219 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2561 acetosyringone 100 µM 2.05544305528412 0.0263843671636567 no 200 0.0199181152485966 249 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2317 5986382 200 µM 2.04948642511353 0.0267344069582281 no 201 0.0202072869557106 168 877883 SGTC_3262 9137218 49.47 µM 2.04859740113805 0.0267869813484268 no 202 0.0202507494947449 90 17650664 SGTC_67 0335-0847 266 µM 2.04822921066901 0.0268087803701482 no 203 0.0202687727581009 367 4552207 YOR254C SEC63 SGTC_1785 bathophenanthroline 24 µM 2.03424283633939 0.0276478897494669 no 204 0.020963558767258 257 72812 An iron chelator. SGTC_2379 9035213 200 µM 2.03006866659771 0.0279025191241218 no 205 0.0211747799815003 206 646551 SGTC_911 3456-4043 236 µM 2.01780367338254 0.0286620241104267 no 206 0.0218058560877732 255 914281 SGTC_137 0438-0332 85.389 µM 2.01277064883985 0.0289786290443551 no 207 0.0220693815278864 383 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1974 st069448 26.9 µM 2.01062119637811 0.0291147243466148 no 208 0.0221827417132497 192 6323587 YNR016C ACC1 SGTC_2344 7990960 76.95 µM 2.0062035008872 0.0293961039000428 no 209 0.0224172702587298 213 140813 SGTC_2897 9048598 12.99 µM 2.00364728080239 0.0295599478670828 no 210 0.0225539286468521 181 6467404 SGTC_1932 st074806 40.9 µM 2.00316996522081 0.0295906258052298 no 211 0.0225795241405549 242 17251235 SGTC_1850 st056238 17 µM 1.99881617065301 0.0298716737013503 no 212 0.0228141237493502 232 5393177 SGTC_947 3447-0010 211 µM 1.99650431557379 0.0300218072658649 no 213 0.0229395282421327 196 748350 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.99262205402161 0.0302753315060261 no 214 0.023151424186381 225 75037 A free radical scavenger. SGTC_194 1486-1323 56.904 µM 1.99124701440203 0.0303655504849358 no 215 0.0232268687349394 205 5178754 SGTC_553 k007-0256 45.7 µM 1.99047626257969 0.0304162183421783 no 216 0.0232692481580094 242 6287000 SGTC_2981 9013952 38.96 µM 1.98857601033966 0.0305414368473659 no 217 0.023374010743797 244 2996344 SGTC_661 1304-0007 33.6 µM 1.98740565941655 0.0306187702322541 no 218 0.0234387305172676 199 3117130 SGTC_3124 9127567 49.47 µM 1.97711804404564 0.0313055478768588 no 219 0.0240141443089782 191 17592030 SGTC_2156 5649887 115 µM 1.97226653119267 0.0316338169271797 no 220 0.0242895940981805 244 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_90 0870-0863 4.608 µM 1.97100544979307 0.0317196100436591 no 221 0.0243616262306762 266 1738164 SGTC_2364 9055074 200 µM 1.96150089215371 0.0323724215510139 no 222 0.0249103105154711 224 6470630 SGTC_316 k060-0003 58.6 µM 1.96113337002528 0.0323978854435068 no 223 0.0249317334610027 208 6152314 SGTC_749 1000-0129 128 µM 1.95551627355639 0.0327891285451527 no 224 0.0252610822397142 247 708470 SGTC_105 0111-0055 734.78 µM 1.95317477227914 0.0329533655515925 no 225 0.0253994446595747 175 5179370 SGTC_2777 climbazole 1.536 µM 1.9529851999122 0.03296669210485 no 226 0.0254106744666612 267 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_17 0960-0276 49.807 µM 1.94832726102386 0.033295533527031 no 227 0.0256879086201378 280 6821114 SGTC_1490 4089-0339 670 nM 1.94676725521533 0.0334062689586041 no 228 0.0257813221703894 153 742542 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.94513829543999 0.0335222224802605 no 229 0.0258791679526172 243 16486 A toxic proline analog. SGTC_1322 1348-1070 12 µM 1.93990927544563 0.0338966781632189 no 230 0.0261953583184982 169 6758089 SGTC_311 1315-0136 58 µM 1.93780267000334 0.034048503527132 no 231 0.0263236509542545 202 6759207 SGTC_25 0118-0223 35.662 µM 1.93520098045066 0.0342367814542876 no 232 0.0264828187434492 232 5333628 SGTC_579 4491-1009 110 µM 1.93515768096157 0.0342399221579695 no 233 0.0264854745350943 317 1271041 SGTC_2240 6690706 185.951 µM 1.93133439510901 0.0345181770954676 no 234 0.026720856249966 204 805876 SGTC_914 3820-6779 408 µM 1.93000675112735 0.0346152351801824 no 235 0.0268030006310716 246 2893481 SGTC_3245 9134821 49.47 µM 1.92937743497106 0.0346613199024685 no 236 0.0268420114684253 251 17014901 SGTC_1105 epirubicin 18.1 µM 1.92318665051005 0.0351173614554941 no 237 0.0272283065854541 223 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2755 lomerizine 42.69 µM 1.90994915740945 0.0361090221635095 no 238 0.0280698799459302 261 3949 A calcium channel blocker. SGTC_3085 9117376 49.47 µM 1.90808873212559 0.0362502125817716 no 239 0.0281898744053507 235 16480349 SGTC_639 0833-0042 114 µM 1.90700875112929 0.036332381053408 no 240 0.0282597271388042 280 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_13 0199-0087 65 µM 1.90453437524822 0.0365212144809171 no 241 0.0284203120728417 226 4589825 SGTC_2146 5545642 200 µM 1.90410120518612 0.0365543545559757 no 242 0.0284485023959895 215 825326 SGTC_2127 5253358 187.912 µM 1.89755142147294 0.0370584571257486 no 243 0.0288775994421637 242 20612 SGTC_80 0159-0065 512.242 µM 1.8969138232696 0.0371078317454209 no 244 0.0289196563651034 141 1548079 SGTC_2421 5690543 90.72 µM 1.89674139305301 0.0371211937067415 no 245 0.0289310388594953 260 3397993 SGTC_2009 4012297 12.05 µM 1.88639016276189 0.0379305625385131 no 246 0.0296211986081116 282 45595307 SGTC_3068 9116768 49.47 µM 1.88245851629856 0.0382417290572375 no 247 0.0298868936331748 246 41904888 SGTC_1400 3771-8998 51.5 µM 1.88137808214605 0.0383276026712949 no 248 0.0299602531014931 185 670767 SGTC_854 0422-0053 192 µM 1.88058826055382 0.0383904776279489 no 249 0.0300139749496539 230 3596728 SGTC_2586 curcumin 80 µM 1.87923120105697 0.0384987047555575 no 250 0.0301064655356688 341 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_211 3455-0679 143.504 µM 1.85767829537238 0.0402511519609716 no 251 0.031607356263508 287 748649 SGTC_22 0964-0034 14.468 µM 1.85257670439203 0.0406753030291079 no 252 0.0319715270025633 327 138402 SGTC_1231 0242-0792 125 µM 1.85240160808656 0.0406899248400132 no 253 0.0319840872840539 255 3707635 SGTC_1155 4088-0394 48.2 µM 1.8500674170313 0.0408852544766037 no 254 0.0321519166986893 269 2326248 SGTC_1502 4534-4282 27.7 µM 1.84647013902773 0.0411877704966966 no 255 0.032411985641345 215 3278949 SGTC_197 4544-0043 41.561 µM 1.84288658611359 0.0414909341717665 no 256 0.0326727855926151 333 896523 SGTC_730 1436-0052 41.2 µM 1.84168634987749 0.0415928758083407 no 257 0.0327605210021338 217 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2912 7964298 10.93 µM 1.8388632872847 0.0418334516435274 no 258 0.0329676484213808 364 2975850 SGTC_1302 1159-0335 255 µM 1.83883857990041 0.0418355621215325 no 259 0.032969465949219 248 649284 SGTC_1333 1482-0047 286 µM 1.83791948422877 0.0419141315538779 no 260 0.0330371352785143 296 3811116 SGTC_2861 9024595 19.48 µM 1.83386024084224 0.042262568470075 no 261 0.0333373713823261 148 16482810 SGTC_1652 st011932 78 µM 1.83039326931072 0.0425620183065968 no 262 0.0335955767218864 241 1551076 SGTC_354 2783-3500 4.88 µM 1.83021819632607 0.0425771851298563 no 263 0.0336086589525838 310 6740761 SGTC_1611 st001856 99.4 µM 1.82894742075548 0.042687405265931 no 264 0.0337037426640244 270 647478 SGTC_2963 9082507 9 µM 1.82542665537302 0.042993982472414 no 265 0.0339683349563667 258 16459611 SGTC_1288 0973-0013 65.5 µM 1.8218599051945 0.0433063754010328 no 266 0.0342381226793909 269 4315430 SGTC_2479 5617353 43.85 µM 1.82099182746366 0.0433826824399694 no 267 0.0343040495896852 301 2731746 SGTC_1259 0671-0132 43 µM 1.81872320610839 0.0435826147437697 no 268 0.0344768347310775 295 X1259 SGTC_918 glabranin 770.725 nM 1.81213488210384 0.0441674583303355 no 269 0.0349826788633825 302 124049 Also referred to as licorice root. SGTC_200 k038-0079 37.545 µM 1.81144674227562 0.0442289075154276 no 270 0.0350358630226692 272 3436683 SGTC_214 4373-3496 70 µM 1.80839929086779 0.0445018662089245 no 271 0.0352721891155494 413 3779166 SGTC_627 1391-0720 175 µM 1.80731562990068 0.0445992556657065 no 272 0.0353565401988101 267 997839 SGTC_1867 st057372 64 µM 1.80613079292702 0.0447059342801697 no 273 0.035448955973612 259 688837 SGTC_2470 5664817 21.68 µM 1.80347162437138 0.044946104789488 no 274 0.0356570889552787 240 2859561 SGTC_2541 muurolladie-3-one 83.07 µM 1.80338464441787 0.0449539781435313 no 275 0.0356639137524498 281 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_809 3998-0021 90 µM 1.8004543682188 0.0452198736842595 no 276 0.0358944613367283 239 715485 SGTC_3126 9127922 49.47 µM 1.79862079570825 0.0453868960937732 no 277 0.0360393427488321 311 45595682 SGTC_1052 3253-3998 198 µM 1.79709748860598 0.0455260330697698 no 278 0.0361600721769737 333 5450317 SGTC_1853 st056710 91.2 µM 1.7932413508044 0.0458797812425775 no 279 0.036467170391416 273 269167 SGTC_107 0358-0022 2.6945 µM 1.78776946418461 0.0463855395960151 no 280 0.0369066046618836 182 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_644 1498-1197 63.3 µM 1.7861066433255 0.0465401152922134 no 281 0.0370409963614963 314 6741615 SGTC_1223 0764-0573 147 µM 1.78451235223161 0.0466887084050348 no 282 0.0371702247326482 328 1609797 SGTC_728 3030-5151 22.5 µM 1.78025477202806 0.0470873948651961 no 283 0.0375171376466804 260 3125388 SGTC_1017 4239-0030 168 µM 1.7789199501915 0.0472129501756118 no 284 0.0376264434124891 328 1149593 SGTC_455 paf C-16 10 µM 1.77825776248867 0.0472753360344321 no 285 0.0376807649833309 269 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2715 st079500 56.4 µM 1.77820226674153 0.0472805673846893 no 286 0.0376853203993752 248 28246688 SGTC_226 1,3-diallylurea 8.28947 mM 1.7692175972696 0.0481336507342504 no 287 0.0384287843178569 253 74537 YKL182W FAS1 SGTC_1557 sumaresinolic acid 42.3 µM 1.76898733679632 0.0481556744954396 no 288 0.0384479939314699 277 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_301 4119-0100 24.5 µM 1.76784215649132 0.0482653275407289 no 289 0.0385436475570828 359 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1472 k841-0093 193 µM 1.75542657174152 0.0494670065448475 no 290 0.0395931851481625 341 X1472 SGTC_120 rhodamine 6G 52.259 µM 1.751551655733 0.0498469033043283 no 291 0.0399254658154325 395 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2393 9031399 185.94 µM 1.74543941874209 0.0504508737464124 no 292 0.0404542045646646 314 1526623 YDL150W RPC53 SGTC_2592 piperlongumine 83.33 µM 1.74072403270502 0.0509207893065071 no 293 0.0408659817825847 304 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1815 st051655 58.2 µM 1.74030875685569 0.0509623403460952 no 294 0.0409024086208422 254 5984156 SGTC_2962 9082311 13.18 µM 1.73907955410996 0.0510854882359406 no 295 0.0410103852471985 274 16459453 SGTC_2842 9000675 19.48 µM 1.7357234213313 0.0514229292530976 no 296 0.041306375072793 303 2989072 SGTC_2057 5236571 38.335 µM 1.73363844661749 0.0516334533748967 no 297 0.041491127161592 369 54684039 YBR257W POP4 SGTC_1154 4088-0362 150 µM 1.73342354782389 0.0516551910381431 no 298 0.0415102076030192 374 6618304 SGTC_3033 9090887 49.47 µM 1.73223844666813 0.0517751983275248 no 299 0.0416155581534392 361 19325384 SGTC_1727 st034309 9.9045 µM 1.73099251636585 0.0519016042253618 no 300 0.0417265496142543 401 870305 SGTC_3091 9116372 49.47 µM 1.72909268968668 0.0520948231338086 no 301 0.0418962536581938 293 17169793 SGTC_282 k297-0036 65.7 µM 1.72258537980925 0.0527609724368617 no 302 0.0424817653731123 250 5061378 SGTC_697 0508-1955 564 µM 1.71989292330976 0.0530385666082332 no 303 0.0427259535644331 351 6243113 SGTC_908 3448-7491 47.7 µM 1.70419409091609 0.0546802611250201 no 304 0.0441724163982358 471 1203031 SGTC_566 0958-0068 16.5 µM 1.70070685154811 0.0550503346295786 no 305 0.0444990239541458 272 6815365 SGTC_1573 oleylamine 1.06 µM 1.69916729294533 0.0552143443856367 no 306 0.0446438335375343 336 5356789 An amine of the fatty acid oleic acid. SGTC_1911 st060208 74.3 µM 1.69915259826702 0.055215911672689 no 307 0.0446452175330473 344 688783 SGTC_2062 5245942 200 µM 1.69655282873487 0.0554937482077816 no 308 0.0448906171956092 354 1376160 SGTC_756 0508-1999 28.3 µM 1.69468429364698 0.0556941187810193 no 309 0.0450676633777235 323 6753853 SGTC_2334 9017922 200 µM 1.69127251709636 0.0560614499802059 no 310 0.0453923832400583 309 3163164 SGTC_1432 4049-0298 68.4 µM 1.68233458073015 0.0570328209451978 no 311 0.0462519895564113 293 741646 SGTC_1384 3089-0840 101 µM 1.68103840953995 0.0571747818276581 no 312 0.046377727109188 290 1069836 SGTC_1778 st046819 58.9 µM 1.67700243217682 0.0576185969821203 no 313 0.046771003121726 381 671715 SGTC_2413 inermin 26.06 µM 1.67647199175728 0.0576771276204808 no 314 0.046822888929048 381 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3228 9131799 49.47 µM 1.6752596206665 0.0578110804112635 no 315 0.0469416521507798 305 17015818 SGTC_1539 benzyladenosine 56 µM 1.66900218866527 0.0585063461173771 no 316 0.0475584730298259 293 92208 A nucleotide analog. SGTC_2930 9013230 14.89 µM 1.66316199827464 0.0591611594653984 no 317 0.0481400061320163 390 2995857 SGTC_1952 st077036 64.1 µM 1.64734379701477 0.0609636084777692 no 318 0.0497437002368232 369 2937007 SGTC_3310 9130229 44.1445 µM 1.64406115657739 0.0613429824181761 no 319 0.0500817852227991 337 7761258 SGTC_2203 7227154 166.4 µM 1.64350361026349 0.0614076007494623 no 320 0.0501393894987939 309 896304 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.64286160779062 0.0614820732043572 no 321 0.0502057849871808 423 91467 include heat shock SGTC_2019 4016004 108 µM 1.6396916293443 0.061850826071705 no 322 0.0505346501325475 307 45595336 SGTC_1388 3346-4487 254 µM 1.63968922300021 0.0618511066478368 no 323 0.0505349004257449 374 3345614 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.63687232087481 0.062180235041943 no 324 0.050828575246308 385 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2722 naftopidil 47.16 µM 1.63258514951965 0.0626837704817144 no 325 0.0512781383207266 344 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1480 1070-0044 41.2 µM 1.63053753659195 0.0629253847527343 no 326 0.0514939692825625 346 3124987 SGTC_3155 9099265 49.47 µM 1.62528931969578 0.0635479770402799 no 327 0.0520504630409674 323 25236499 SGTC_2630 antimycin a 100 µM 1.62475820499329 0.0636112489746227 no 328 0.0521070448977414 403 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3 0833-0587 95.581 µM 1.62382696209238 0.0637223066710831 no 329 0.0522063720007017 322 5382644 SGTC_2774 tamoxifen 10.92 µM 1.61980831376656 0.064203291362594 no 330 0.0526367299170983 353 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3029 9088683 49.47 µM 1.60380663474943 0.0661465376821014 no 331 0.0543783408402272 337 25236615 SGTC_808 0711-0032 135 µM 1.60257333834401 0.0662981802463475 no 332 0.0545144419913843 346 4252555 SGTC_3045 9092950 49.47 µM 1.59824383604296 0.0668326554628523 no 333 0.0549943607014839 393 44120432 SGTC_313 3474-0040 5.03 µM 1.59470227645438 0.0672723332607607 no 334 0.0553894143747541 449 1043375 YIL048W NEO1 SGTC_2049 5262831 67.185 µM 1.59033589547593 0.0678174851843127 no 335 0.0558795557944462 370 763417 SGTC_2040 5100729 123 µM 1.58659949759896 0.0682866860604113 no 336 0.0563016906530656 394 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3171 9103192 49.47 µM 1.58631324519023 0.0683227354725476 no 337 0.0563341345883789 312 13018434 SGTC_1323 1348-1351 11.2 µM 1.57191520352784 0.0701549766759077 no 338 0.0579851090603768 351 6989654 SGTC_2281 7943571 200 µM 1.56928362390551 0.0704939097632819 no 339 0.058290933188669 383 1244024 SGTC_1634 st006576 41 µM 1.56923156147777 0.070500627795148 no 340 0.0582969962831059 364 3915356 SGTC_1401 3807-4679 7.6 µM 1.56919996053248 0.0705047057581373 no 341 0.0583006767125752 346 3291456 SGTC_744 1594-0068 283 µM 1.56781962597483 0.0706830088604749 no 342 0.0584616166569025 449 668392 SGTC_3263 9137018 49.47 µM 1.56318704699147 0.0712839504506921 no 343 0.0590043029498896 394 43844957 SGTC_418 lividomycin a 100 µM 1.55028644795801 0.0729780964744295 no 344 0.060536389299656 382 72394 An antibiotic. SGTC_2567 aureobasidin a 60 nM 1.54938245976548 0.073097956612065 no 345 0.0606449038638623 450 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1007 4101-0031 70 µM 1.547666490804 0.0733258918937746 no 346 0.060851306912741 403 1146276 SGTC_1418 3966-3099 2.4 µM 1.54709800923479 0.0734015241069379 no 347 0.0609198069619993 424 740335 SGTC_306 1672-3436 11.6 µM 1.54552471040982 0.0736111507890918 no 348 0.0611096983099878 393 6797378 SGTC_3121 9125696 49.47 µM 1.53893283172411 0.0744944332804607 no 349 0.0619103474627344 325 1235365 SGTC_1646 st011709 75.6 µM 1.53548223962025 0.0749600118915067 no 350 0.0623327081924883 339 5757843 SGTC_812 4251-0442 148 µM 1.53548163216331 0.074960094048897 no 351 0.0623327827440038 372 5723007 SGTC_1330 1469-0054 61.8 µM 1.53025785407525 0.0756691430524768 no 352 0.0629764580189164 408 7102664 SGTC_2259 7964009 200 µM 1.52723540970003 0.0760817211787167 no 353 0.0633512420797094 370 313134 SGTC_2834 9001755 58.44 µM 1.52271977864228 0.0767013139322111 no 354 0.0639144137413533 374 2989575 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.51528897270356 0.0777292414874716 no 355 0.0648496198394089 477 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_711 k292-0785 179 µM 1.51520727897422 0.0777406002773626 no 356 0.0648599601537829 403 4146315 SGTC_3114 9122766 49.47 µM 1.51097426216632 0.0783308894407645 no 357 0.0653975042524658 403 17176985 SGTC_484 loperamide 105 µM 1.51056182691931 0.0783885842636302 no 358 0.0654500629529889 282 3955 An opioid-receptor agonist. SGTC_1745 st081495 74 µM 1.50981557358114 0.0784930581815296 no 359 0.0655452450320851 481 13842402 YBL026W LSM2 SGTC_1441 4106-0040 13 µM 1.50923382929884 0.078574574362527 no 360 0.0656195189643919 399 2904180 SGTC_2765 myclobutanil 7.74 µM 1.50687207719197 0.0789061710262067 no 361 0.0659217249779095 428 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2572 astragaloside iv 100 µM 1.5056774572134 0.0790743022444183 no 362 0.0660749968228789 418 45006101 An anti-inflammatory agent. SGTC_1387 3342-1166 1.8 µM 1.5009873413301 0.0797370149321493 no 363 0.0666794178621873 319 3418228 SGTC_453 enantio-paf c16 10 µM 1.50092111292141 0.079746402986841 no 364 0.0666879833336557 612 13871343 A lipid and platelet activating factor SGTC_1220 1838-0075 193 µM 1.49817639541209 0.0801362098195972 no 365 0.0670437133504449 431 5529645 SGTC_2034 5197015 53.07 µM 1.49750449770762 0.0802318523220972 no 366 0.0671310180760443 416 780676 SGTC_3286 9117135 37.221 µM 1.49516618004002 0.0805653770320904 no 367 0.0674355387654077 430 3438150 SGTC_847 0342-0274 5.54 µM 1.49427989075328 0.0806920657725431 no 368 0.0675512394367896 418 18097 SGTC_428 3448-4153 16.5 µM 1.4886243707537 0.0815040273910307 no 369 0.0682931551982551 384 3834874 SGTC_2800 7887935 81.82 µM 1.48642327095004 0.0818216990447153 no 370 0.0685835991376598 405 2961002 SGTC_1588 farnesol 29.9 µM 1.48438022512283 0.0821173939772431 no 371 0.0688540389385486 428 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1163 k060-0048 49.9 µM 1.47826620323037 0.0830071001479832 no 372 0.0696682699940802 476 6809982 SGTC_1675 st018485 24.5 µM 1.47804606139217 0.0830392696617935 no 373 0.0696977249079591 426 3323024 SGTC_77 0828-0286 12.516 µM 1.47493127177444 0.083495441963436 no 374 0.0701155109511261 460 745345 SGTC_61 0978-8327 98.565 µM 1.46931542416416 0.0843226580151287 no 375 0.0708736275779915 452 6150059 YHR072W ERG7 SGTC_608 k048-0125 159 µM 1.46900245981678 0.0843689380361691 no 376 0.0709160610188561 447 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3179 9107801 49.47 µM 1.46701858144455 0.084662750145863 no 377 0.0711855003351437 426 4818259 SGTC_574 1315-0397 40 µM 1.46553348501613 0.0848831944699739 no 378 0.0713877117693036 522 6794277 SGTC_475 α-linolenic acid 10 µM 1.46008155644085 0.0856961565139903 no 379 0.0721338304292562 461 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2669 eugenol 100 µM 1.45917128164256 0.0858324577421792 no 380 0.0722589854824695 357 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2178 5812956 200 µM 1.45515911121631 0.0864351596900307 no 381 0.0728126088661433 413 5403383 SGTC_524 r073-0010 27.8 µM 1.45428948518052 0.0865662098007785 no 382 0.0729330322082502 428 2772106 SGTC_402 epigallocatechin gallate 10 µM 1.45413656024976 0.0865892704902377 no 383 0.0729542245708605 465 65064 An antioxidant. SGTC_132 0417-1715 25.805 µM 1.44448929744767 0.0880533522796009 no 384 0.0743006940675351 469 6769098 SGTC_2266 7929956 200 µM 1.4424972987118 0.0883579464976559 no 385 0.074581066545817 481 2967153 SGTC_1719 st032227 49.2 µM 1.43518023900524 0.0894835297376072 no 386 0.0756178715993653 457 3125804 SGTC_447 ml7 120 µM 1.43290202775405 0.0898361548953387 no 387 0.0759429188584223 458 4216 Selective myosin light chain kinase inhibitor. SGTC_1107 amlodipine 47 µM 1.43167059306838 0.0900271878191501 no 388 0.0761190580732115 465 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1249 0481-0015 10.2 µM 1.42957008875245 0.0903537361103295 no 389 0.0764202227230495 396 4227577 SGTC_3049 9092223 49.47 µM 1.42946088960821 0.0903707364326432 no 390 0.0764359041564575 433 8623917 SGTC_225 nsc-122657 1.016 µM 1.42753898695278 0.0906703306526846 no 391 0.0767122979206489 309 275685 SGTC_421 streptovitacin 30 mM 1.42590112771445 0.0909262282632081 no 392 0.0769484419345194 503 91467 include heat shock SGTC_2400 5203494 178.7 µM 1.42377685889253 0.0912589196509536 no 393 0.0772555382778911 434 6777674 SGTC_520 3584-0023 682 µM 1.42227118144971 0.0914952766391912 no 394 0.0774737707950061 461 1340790 SGTC_1354 1498-1681 81 µM 1.42155407563154 0.0916080052491778 no 395 0.0775778723737772 509 5754243 SGTC_2095 5432005 200 µM 1.41173943498477 0.0931612183651554 no 396 0.0790133486698482 425 783734 SGTC_838 0109-0203 71.4 µM 1.40973930366594 0.0934801218648873 no 397 0.0793083373444931 483 759422 SGTC_1060 3448-7350 82 µM 1.40684415562401 0.0939431551220585 no 398 0.0797368029802053 511 570178 SGTC_2709 st078560 56 µM 1.40285850995064 0.0945833622190499 no 399 0.0803295176276891 457 17250903 SGTC_1267 0828-0272 9.49 µM 1.40230735028616 0.0946721465302636 no 400 0.0804117432187577 520 745334 SGTC_2175 5807670 165.306 µM 1.39735409564506 0.0954728064068513 no 401 0.0811535579799225 445 241186 SGTC_2954 9074818 52.69 µM 1.39522009426837 0.0958192851676 no 402 0.0814747396451048 473 16648742 SGTC_3318 9139014 38.6185 µM 1.39481604324312 0.095884991337712 no 403 0.0815356598527954 441 16643984 SGTC_2676 harmalol 100 µM 1.39359449557119 0.0960838391160021 no 404 0.081720045832481 494 5459187 A monoamine oxidase inhibitor SGTC_2705 st078069 42.8 µM 1.39070631759904 0.0965551923466117 no 405 0.0821572505464322 461 1530061 SGTC_104 0074-0074 590.992 µM 1.38997751383241 0.0966744017357396 no 406 0.0822678528238476 332 3943124 SGTC_347 4534-1311 26.2 µM 1.38640256665327 0.0972607166249158 no 407 0.0828120065797837 483 2862016 SGTC_411 enrofloxacin 100 µM 1.38519251241491 0.0974597633348967 no 408 0.0829968048086927 461 71188 A bacterial gyrase inhibitor. SGTC_1907 st060210 83.7 µM 1.38450603977032 0.0975728167421448 no 409 0.0831017800056545 542 688793 SGTC_717 1532-0246 73.2 µM 1.38280850198467 0.097852792748679 no 410 0.0833617956952374 507 9561992 SGTC_111 0083-0039 52.457 µM 1.38168423019405 0.0980385434863107 no 411 0.0835343392704149 320 759313 SGTC_3347 9188721 44.724 µM 1.38025006846136 0.0982758686768461 no 412 0.0837548314461087 441 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2071 5230951 39.92 µM 1.37984174493445 0.0983435149780989 no 413 0.0838176881716722 514 1799272 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.37829759930871 0.0985996394136771 no 414 0.0840557120551614 528 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3323 9138564 53.9225 µM 1.37623706518375 0.0989421762807388 no 415 0.0843741251198243 547 43912313 YNL103W MET4 SGTC_2546 rhodinyl acetate 100 µM 1.37343926433343 0.0994086665156155 no 416 0.0848079152059011 504 6708682 SGTC_2662 daunorubicin 22.37 µM 1.36201787823228 0.101329686846279 no 417 0.0865961215026322 446 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1108 betulinic acid 729.144 nM 1.36200925043261 0.101331148150777 no 418 0.0865974828984381 512 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2086 5274770 176.623 µM 1.35763569661176 0.102073881899766 no 419 0.0872896550874413 492 689278 SGTC_830 4076-0286 57.8 µM 1.35363690295195 0.102756431803378 no 420 0.0879261237265125 670 6866659 SGTC_485 niflumic acid 177 µM 1.35362648191954 0.102758214881124 no 421 0.0879277869011341 473 4488 A COX2 inhibitor. SGTC_387 norethindrone acetate 66.7 µM 1.35128182777041 0.103159965851649 no 422 0.0883025854662136 467 541197 SGTC_147 4466-0538 29.23 µM 1.35024542742773 0.103337913688917 no 423 0.0884686354905212 541 6742687 YHR072W ERG7 SGTC_1886 st057356 49.9 µM 1.34909543821054 0.103535625203225 no 424 0.0886531566640212 487 24207747 SGTC_602 3130-1533 38.1 µM 1.34811924542395 0.103703672130562 no 425 0.0888100161972801 563 720941 SGTC_2307 7538926 6.34 µM 1.34730379333729 0.103844199935951 no 426 0.0889412054537754 536 96582 SGTC_3234 9132280 49.47 µM 1.34591005070591 0.10408470491662 no 427 0.0891657635332669 538 17612295 SGTC_3258 9138477 49.47 µM 1.34335423279519 0.104526787059015 no 428 0.0895786495066883 497 4970355 SGTC_1766 st045414 44.774 µM 1.34253239595974 0.104669229544417 no 429 0.0897117168039801 551 253960 SGTC_2017 5132927 60.65 µM 1.33628902332028 0.105755936857868 no 430 0.0907274114465368 523 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_647 0140-0236 81 µM 1.33355206811835 0.106234887881004 no 431 0.0911753502485846 585 990837 SGTC_839 0122-0028 230 µM 1.33301375632094 0.106329273359817 no 432 0.0912636447430707 603 759448 SGTC_1003 4049-0218 100 µM 1.33282363174298 0.106362623524814 no 433 0.0912948443306542 550 295161 SGTC_3015 9080845 49.47 µM 1.33114216152521 0.106657902723765 no 434 0.0915711191683108 541 5296973 SGTC_3026 9090633 49.47 µM 1.32908319035055 0.107020279245718 no 435 0.0919102627099988 527 25236842 SGTC_1845 st056753 3.01 µM 1.32531985681847 0.107684914899054 no 436 0.0925325428612815 541 5375839 SGTC_2304 7443016 91.4 µM 1.3219710631575 0.108278835381995 no 437 0.0930888934357034 467 939854 SGTC_643 k048-0106 28.4 µM 1.32147642534996 0.108366760599076 no 438 0.0931712790171499 540 6763920 SGTC_1838 st055369 84.5 µM 1.32083281317344 0.108481243919466 no 439 0.093278558031361 478 676036 SGTC_1320 1313-0481 95.3 µM 1.31809586750412 0.108969053299192 no 440 0.0937357788581323 535 6813365 YLR208W SEC13 SGTC_3309 9129340 25.759 µM 1.31515419484382 0.109495107356885 no 441 0.0942290429064054 563 17158987 SGTC_2911 7942208 15.64 µM 1.31317128848781 0.109850734453993 no 442 0.0945626182087903 473 1243384 SGTC_672 1441-0018 53.7 µM 1.31036464399021 0.110355511926305 no 443 0.0950362541758028 505 251141 SGTC_2263 7948595 193.29 µM 1.30590178349784 0.111161582639531 no 444 0.0957929800071773 462 2971371 SGTC_106 0092-0003 11.579 µM 1.30273013241287 0.111736995327032 no 445 0.0963334554921752 446 1072148 SGTC_570 0987-0065 62.6 µM 1.30176870680926 0.111911840796587 no 446 0.0964977321434869 432 3104428 SGTC_2971 9092186 9.93 µM 1.29794068536444 0.112609947341599 no 447 0.0971538589855414 498 25236400 SGTC_1781 st038725 66.3 µM 1.29775195456391 0.112644445969555 no 448 0.0971862921209048 637 4270275 YIL048W NEO1 SGTC_209 4077-0173 175.592 µM 1.29610207448639 0.112946353570486 no 449 0.0974701601908004 427 15993494 SGTC_626 0214-0009 33 µM 1.29504702708723 0.113139716668556 no 450 0.0976520035700393 573 3437874 SGTC_499 genistein 192 µM 1.29313758144209 0.113490269378375 no 451 0.0979817395798613 491 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3073 9114972 49.47 µM 1.29186226379829 0.113724834321054 no 452 0.0982024240724669 486 41905075 SGTC_2189 6047310 154.431 µM 1.29113455977624 0.113858833252767 no 453 0.0983285110302591 525 711535 SGTC_999 SEC7.066 22.7 µM 1.28404862924846 0.115169516127389 no 454 0.0995624703864192 590 740511 YDR170C SEC7 SGTC_420 mitomycin C 81.9 mM 1.27882848032582 0.116141923671132 no 455 0.100478731168445 576 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3067 9117431 49.47 µM 1.27724647024228 0.116437767250844 no 456 0.100757622764289 509 17150885 SGTC_578 3460-0051 92 µM 1.27679028927639 0.116523174520506 no 457 0.100838147393209 624 2876744 SGTC_2292 7671323 168.05 µM 1.27645563988899 0.116585856609717 no 458 0.10089724921514 565 937504 SGTC_1789 tunicamycin 25 nM 1.27480753165044 0.116894907279995 no 459 0.101188687117018 545 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1504 k297-0033 30 µM 1.27395914093259 0.117054222367301 no 460 0.101338948498893 455 4388117 SGTC_1703 st026983 48.3 µM 1.27368036512461 0.117106605862435 no 461 0.101388358901957 596 1104023 SGTC_2047 4141938 200 µM 1.27361058157136 0.117119721171574 no 462 0.101400730129616 503 3807862 SGTC_2438 5259590 200 µM 1.2724562048599 0.117336828850877 no 463 0.101605537590924 586 1201127 SGTC_1545 lovastatin 49.4 µM 1.26482896043151 0.118778475856507 no 464 0.102966323726034 604 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1314 1222-0010 41.1 µM 1.26275428599346 0.11917277146482 no 465 0.103338749019581 561 3526027 SGTC_3240 9133527 49.47 µM 1.26221444620238 0.119275520301969 no 466 0.103435815926138 577 17617455 SGTC_1621 st003705 32.4 µM 1.25926339630781 0.119838304874638 no 467 0.103967604849167 632 24207032 SGTC_3039 9090270 49.47 µM 1.25561134302921 0.120537364111872 no 468 0.104628458395116 539 17173750 SGTC_1286 0929-0070 131 µM 1.25216827233647 0.12119904601149 no 469 0.105254277224938 616 1420408 SGTC_927 2425-1185 123 µM 1.24402511061051 0.122774135485945 no 470 0.106745160662248 571 730375 SGTC_1131 3454-3128 32.3 µM 1.24204271014709 0.123159744121446 no 471 0.107110402115096 631 710982 SGTC_2926 9010726 65.15 µM 1.23990810790941 0.123575906632675 no 472 0.107504692316191 587 2994293 SGTC_1962 st076595 64.5 µM 1.2373431360981 0.124077275493321 no 473 0.107979859954865 598 279619 SGTC_1829 berberine 14.4 µM 1.23705920078287 0.124132863016949 no 474 0.108032552529767 570 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2568 diosmetin 100 µM 1.23472470545728 0.124590560119257 no 475 0.108466488998839 616 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1404 3909-7820 48.3 µM 1.23311085982245 0.124907656742379 no 476 0.108767203158907 582 23741373 SGTC_419 nsc-638432 893 µM 1.22449501955664 0.126610079815156 no 477 0.110382771990281 604 368090 SGTC_2090 5301565 104.445 µM 1.22006825094042 0.127491031522063 no 478 0.111219501487627 663 2056344 SGTC_3283 9109332 35.8195 µM 1.21992422680381 0.127519764547898 no 479 0.111246800402595 504 17027281 SGTC_108 0509-0257 621.132 µM 1.21946516963224 0.127611377171849 no 480 0.111333843959874 661 536624 SGTC_276 colchicine 750 µM 1.21831460303899 0.127841193226934 no 481 0.111552221413861 627 2833 A microtubule depolymerizer. SGTC_463 ikarugamyin 104 µM 1.21829400325588 0.127845310480493 no 482 0.111556134042078 527 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1523 st012844 44.7 µM 1.21607888055494 0.128288582150228 no 483 0.111977437435867 614 4274103 SGTC_237 nikkomycin 200 µM 1.21224313450638 0.129058680918101 no 484 0.112709662193699 641 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1819 st053448 58.6 µM 1.21117863326876 0.129272966783518 no 485 0.112913474907551 597 2857616 SGTC_1980 st071811 45.7 µM 1.21105449593759 0.129297971880869 no 486 0.112937259744217 596 4974850 SGTC_1072 oxiconazole 14.9 nM 1.21051036976439 0.129407615267997 no 487 0.113041557055051 640 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3028 9087778 49.47 µM 1.20803711162248 0.129906797594149 no 488 0.113516493854246 582 17217395 SGTC_470 aa-861 153 µM 1.20695487422188 0.130125646347235 no 489 0.113724761507522 658 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2543 pimpinellin 60.67 µM 1.20155396465957 0.13122162492893 no 490 0.114768193254366 592 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_798 1287-0182 476 µM 1.2003165924043 0.131473613483453 no 491 0.115008204069275 681 1649755 SGTC_1863 st057641 20.1 µM 1.19706696076145 0.132136984842623 no 492 0.115640228215604 678 3921635 SGTC_2323 6148992 148.28 µM 1.19629687338172 0.132294526143805 no 493 0.115790364232228 554 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1238 0333-0287 48.8 µM 1.19144486398487 0.133290107633862 no 494 0.116739494697007 618 7226 SGTC_1530 rhein 70.4 µM 1.18875816246636 0.133843602617756 no 495 0.117267422905145 673 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3012 9080433 71.4286 µM 1.1866787499844 0.134273071320769 no 496 0.117677180047038 653 17688859 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.18316938658355 0.135000017528223 no 497 0.118371011510562 686 1377 SGTC_776 4476-4378 112 µM 1.18053241950295 0.135548024485625 no 498 0.118894262109438 602 2892008 SGTC_2917 7979103 53.79 µM 1.17931556980896 0.135801419962329 no 499 0.11913627034442 694 2980565 SGTC_2832 7992762 51.95 µM 1.17677500678573 0.136331509265642 no 500 0.11964266039262 540 2985177 SGTC_1765 st044815 90.4 µM 1.17540989220713 0.136616924811403 no 501 0.119915383880267 624 645695 SGTC_970 1315-0089 19.5 µM 1.17465778960668 0.136774347433439 no 502 0.120065826532538 602 6811083 YLR033W RSC58 SGTC_1281 0884-0031 11.8 µM 1.17327476461628 0.137064152012293 no 503 0.120342819325662 666 1548255 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.1691339118775 0.137934350105816 no 504 0.121174841383725 563 279621 SGTC_1062 mesoridazine 14.2 µM 1.16874981742339 0.138015257933735 no 505 0.121252222085943 660 4078 A neuroleptic. SGTC_2272 7805186 180 µM 1.16851873048348 0.138063950985695 no 506 0.121298794222644 631 2956062 YPR165W RHO1 SGTC_1148 3909-7663 27.7 µM 1.1670616857282 0.13837123925153 no 507 0.121592729629033 664 4084526 SGTC_1040 k898-0338 155 µM 1.16463879584069 0.13888325402129 no 508 0.122082616474972 710 20969351 SGTC_1023 4482-3888 16 µM 1.16101576954498 0.139651290641976 no 509 0.122817743247214 647 3303168 SGTC_799 1310-0557 151 µM 1.16094122397206 0.13966712364191 no 510 0.122832901370629 648 5354492 SGTC_2988 9073640 71.4286 µM 1.15389734714039 0.141168705914194 no 511 0.12427112846778 614 9102229 SGTC_288 1315-0019 35.1 µM 1.15252054657529 0.141463480232034 no 512 0.124553615800779 682 6811474 SGTC_1479 0549-0158 134 µM 1.1520997041771 0.141553666166627 no 513 0.124640052346494 731 5440202 SGTC_2474 5321570 43.32 µM 1.15193452153034 0.141589075219293 no 514 0.124673990558072 634 2841384 SGTC_1025 k007-0731 70 µM 1.1494983601494 0.142111995052694 no 515 0.125175271275458 636 6256118 SGTC_3150 9097574 49.47 µM 1.14761735497118 0.142516644292533 no 516 0.125563281045557 641 17217476 SGTC_1991 st073000 8.92 µM 1.14734819452317 0.142574610815827 no 517 0.125618871459283 719 4301969 YIL048W NEO1 SGTC_2565 isoliquiritigenin 100 µM 1.14599005563052 0.142867343432202 no 518 0.12589963337356 527 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_38 0929-0051 58.268 µM 1.14598574958348 0.1428682722011 no 519 0.125900524238587 705 1379719 SGTC_12 0849-0099 9.267 µM 1.14590142627359 0.142886460671463 no 520 0.125917970518692 644 6071388 SGTC_1410 3909-8106 77.9 µM 1.14500586695199 0.143079728670036 no 521 0.126103363521687 660 1039210 SGTC_236 1509-0011 5.31 µM 1.14358530191052 0.143386658706164 no 522 0.126397830034648 926 3107280 SGTC_1986 st071812 45 µM 1.1428440481729 0.143546991809637 no 523 0.126551673337405 624 11838594 SGTC_458 nppb 133 µM 1.14075522378042 0.143999455100771 no 524 0.126985899283919 636 4549 A chloride channel blocker. SGTC_369 0957-0393 4.5 µM 1.13940702122836 0.144292001436378 no 525 0.12726671441264 608 6997992 SGTC_877 0771-0151 33.1 µM 1.13788937162907 0.144621795059595 no 526 0.127583339928777 692 6166523 SGTC_2513 baicalein 25.65 µM 1.13591671104193 0.145051223474469 no 527 0.127995711870774 669 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1381 2324-0066 62.1 µM 1.1300932201138 0.146323941526022 no 528 0.129218473143333 646 10885928 SGTC_1092 toremifene 6.32 µM 1.12987246974294 0.146372333353971 no 529 0.12926498295863 725 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2648 atorvastatin 78.68 µM 1.1292243558675 0.146514471820041 no 530 0.129401600872253 659 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_963 1269-2853 151 µM 1.12893482476681 0.146577999088061 no 531 0.129462664343005 637 3668223 SGTC_2827 7993847 71.43 µM 1.1281661600121 0.14674674481597 no 532 0.129624876208319 621 2985692 SGTC_2401 5128683 200 µM 1.12608587705907 0.147204084851373 no 533 0.130064585665091 620 708373 SGTC_228 caffeine 993.056 µM 1.12457498029681 0.147536846464553 no 534 0.130384590415623 638 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1591 genipin 88.4 µM 1.12331476259035 0.147814783401847 no 535 0.130651918107193 650 442424 A DNA cross-linking agent. SGTC_784 4579-0127 173 µM 1.12190362232233 0.148126421636131 no 536 0.130951710180735 729 1948547 SGTC_78 0336-0123 156.75 µM 1.12190166058289 0.148126855175279 no 537 0.130952127276366 624 6765896 SGTC_1156 4092-0367 4.88 µM 1.12184234601176 0.148139963937168 no 538 0.130964738889486 693 1357585 SGTC_1199 1638-0010 4.46 µM 1.1205879296368 0.148417376874537 no 539 0.131231652618676 709 3111136 SGTC_1377 2944-0135 198 µM 1.12015006859813 0.148514291159904 no 540 0.131324908741667 693 1894137 SGTC_2075 5212009 200 µM 1.11989229369288 0.148571365737183 no 541 0.131379831317877 605 780898 SGTC_1264 0783-0040 158 µM 1.11959628299846 0.148636924281867 no 542 0.131442920127833 644 2855798 SGTC_575 k072-0246 11.9 µM 1.11519163964066 0.149614721138747 no 543 0.13238415396508 720 6796779 SGTC_2033 5192550 145 µM 1.11388401338915 0.149905828471067 no 544 0.132664474285678 668 182073 SGTC_1078 idebenone 36.1 µM 1.11334237499606 0.150026520055396 no 545 0.132780706833154 738 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3143 9086658 49.47 µM 1.11291956554595 0.150120778373427 no 546 0.132871488085751 773 25236626 SGTC_1455 4262-0120 131 µM 1.11241154825253 0.150234084561865 no 547 0.132980620792822 728 1529587 SGTC_3223 9129970 49.47 µM 1.10999248806572 0.150774404003352 no 548 0.133501131757046 724 17248386 SGTC_1268 0828-0275 2.46 µM 1.10634418043979 0.151591731356736 no 549 0.134288787988102 737 745337 SGTC_745 0469-0705 296 µM 1.10226339467974 0.152509429741868 no 550 0.13517358922489 793 3486736 SGTC_3167 9103034 49.47 µM 1.09976095153329 0.153074005781836 no 551 0.135718145022316 655 5127859 SGTC_650 1328-0195 38 µM 1.09894363628531 0.153258699963649 no 552 0.13589632579653 731 2780821 SGTC_1978 st071761 42 µM 1.09453179960473 0.154258221014463 no 553 0.13686090426234 670 5147680 SGTC_1957 st077035 62.4 µM 1.09394627607392 0.154391197258358 no 554 0.136989270614892 720 705593 SGTC_231 b-estradiol 524 µM 1.09147491704677 0.154953293942775 no 555 0.137531981524853 631 450 A steroid. SGTC_224 benfluorex 43.875 µM 1.09059789638215 0.155153091862141 no 556 0.137724927804711 642 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1741 st038134 10.228 µM 1.09011821033961 0.155262443159897 no 557 0.137830537791449 754 1272587 SGTC_1093 fluphenazine 7.97 µM 1.08984724834661 0.155324235301443 no 558 0.137890218501655 739 6602611 An atypical antipsychotic. SGTC_3132 9126706 49.47 µM 1.08945638909598 0.155413398272054 no 559 0.137976338223905 684 850858 SGTC_2417 cerulenin 830 nM 1.08835002945072 0.155665964545579 no 560 0.138220306129563 685 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1567 st069303 68.4 µM 1.08648335050505 0.15609271431097 no 561 0.138632601549276 733 5581319 SGTC_2083 5306046 65.942 µM 1.08491166705747 0.156452621102755 no 562 0.138980390046493 711 539837 SGTC_2795 7780010 54.55 µM 1.07780438339216 0.158086967400238 no 563 0.140560531483925 668 953673 SGTC_2195 6536160 144.242 µM 1.07760946049799 0.158131947970803 no 564 0.140604039248932 643 3834386 SGTC_47 0149-0135 24.25 µM 1.07737782832759 0.158185410525862 no 565 0.140655752591831 681 5239155 SGTC_2810 7959871 45.46 µM 1.07593511209751 0.158518667961049 no 566 0.140978138657756 774 2974535 SGTC_2449 5812982 45.77 µM 1.06927545847049 0.160062965989734 no 567 0.14247278283669 688 776185 SGTC_1686 st019653 115.5 µM 1.06750161481603 0.160475953702075 no 568 0.142872692420092 743 97252 SGTC_1348 1493-0373 93.8 µM 1.06610156815902 0.160802404835897 no 569 0.143188865410486 741 3010129 SGTC_364 0083-0097 67.7 µM 1.0657765869738 0.160878243183174 no 570 0.14326232354885 736 5207356 SGTC_1167 k781-0610 148 µM 1.06380895199392 0.161337913524265 no 571 0.143707627573391 787 4525169 SGTC_1834 st055981 52.8 µM 1.06334961169197 0.161445345821402 no 572 0.143811717203664 755 471719 YDL150W RPC53 SGTC_3229 9132204 49.47 µM 1.06245999595596 0.161653545239692 no 573 0.144013454789385 713 17682924 SGTC_1780 st038448 24.544 µM 1.05535419189922 0.163322816256588 no 574 0.145631682473235 746 728868 YDL195W SEC31 SGTC_3335 9143315 29.6265 µM 1.05361014954627 0.163734226188999 no 575 0.146030720232003 725 4899691 SGTC_2028 5153890 36.43 µM 1.0526235691641 0.163967252686592 no 576 0.146256775318654 735 2830968 YPR165W RHO1 SGTC_2251 lansoprazole 556 µM 1.05037924951156 0.164498153474123 no 577 0.146771891044707 597 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_37 0566-0070 1.56 µM 1.05011877869616 0.164559840730609 no 578 0.146831752977662 808 1626686 SGTC_2336 9001819 198.65 µM 1.04922045549159 0.164772705447964 no 579 0.147038333079025 778 2989602 SGTC_1133 3473-0247 50 µM 1.04732983778412 0.165221284566577 no 580 0.147473739533964 733 711311 SGTC_3094 9117742 49.47 µM 1.04638726151862 0.165445220747708 no 581 0.14769113582048 795 17149698 SGTC_2809 7964133 12.99 µM 1.04562779525942 0.165625796635736 no 582 0.147866455577631 751 1253665 SGTC_2068 5226020 147 µM 1.04461186114207 0.165867551279794 no 583 0.148101197691555 781 1810509 SGTC_59 0330-0160 1.33 µM 1.04278407743365 0.166303070031123 no 584 0.148524153701087 881 4293482 SGTC_2239 6685329 187.64 µM 1.03977726494289 0.167021129367374 no 585 0.149221697010355 757 805680 SGTC_2909 7941780 10.49 µM 1.02566033738514 0.170419085701813 no 586 0.152525857970416 806 1243215 SGTC_69 0096-0274 206.684 µM 1.02461419671562 0.170672642648205 no 587 0.152772631585899 848 6741392 SGTC_2353 9059630 146.67 µM 1.02363403423322 0.170910427227756 no 588 0.15300408178393 784 4779114 SGTC_2876 9059903 25.97 µM 1.02315127738598 0.171027620511041 no 589 0.15311816273669 827 6916095 SGTC_2729 fluphenazine 10.66 µM 1.01928150027141 0.171968898280397 no 590 0.154034672049381 800 3372 An atypical antipsychotic. SGTC_1935 st074532 41.6 µM 1.01314569722368 0.173468125737115 no 591 0.155495286851839 876 2829742 SGTC_810 3825-7150 143 µM 1.01286443931798 0.173537047361262 no 592 0.15556245800554 848 22330411 YGL099W LSG1 SGTC_3172 9105863 49.47 µM 1.0126442494302 0.173591016563586 no 593 0.155615058003775 741 2348785 SGTC_923 1900-2434 73.3 µM 1.00997317374536 0.174246555651997 no 594 0.15625407136706 761 5910570 SGTC_1602 st001878 87.6 µM 1.00876836696444 0.174542755132185 no 595 0.156542867575192 795 595405 YLR310C CDC25 SGTC_3221 9128209 49.47 µM 1.00851040930323 0.17460621507503 no 596 0.156604746535685 758 16460723 SGTC_2105 5350118 200 µM 1.00685879736911 0.175012873846496 no 597 0.157001317244818 808 2133313 SGTC_2339 9000433 200 µM 1.00674084709724 0.17504193845378 no 598 0.157029663690134 695 2988954 SGTC_765 1319-0117 244 µM 1.00350165581892 0.175841317332412 no 599 0.157809439206236 739 3487746 YGL099W LSG1 SGTC_1218 1348-1416 30.7 µM 1.00336123120098 0.175876024019345 no 600 0.157843301257429 780 6787668 SGTC_386 1509-0011 3.07 µM 1.00332432695271 0.175885145819326 no 601 0.157852201155059 866 3107280 SGTC_593 1203-0218 61.7 µM 1.00020612079812 0.176656969828892 no 602 0.158605383872756 838 3666956 SGTC_266 formosanin C 406 nM 0.999911075218513 0.176730110784974 no 603 0.158676772081967 797 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2804 7954240 19.48 µM 0.999857686237698 0.176743347806061 no 604 0.158689692145972 839 828705 SGTC_1649 st011737 51.3 µM 0.999282562654819 0.176885981072698 no 605 0.158828915038806 789 1761035 SGTC_2841 9004761 38.96 µM 0.999156228794218 0.176917322187741 no 606 0.158859507996948 712 2991039 SGTC_2588 indole-3-carbinol 100 µM 0.99844838390725 0.177092990439917 no 607 0.15903099087525 850 3712 Induces cell cycle arrest. SGTC_1659 st012954 42.1 µM 0.998294351409211 0.17713123179773 no 608 0.159068322931681 785 24207262 SGTC_496 calpeptin 138 µM 0.995366358247565 0.177859150940888 no 609 0.159779057206813 710 73364 A calpain inhibitor. SGTC_1578 josamycin 24.2 µM 0.991289481631882 0.178875827919242 no 610 0.160772123793794 737 5282165 A P450 substrate. SGTC_942 3253-1115 227 µM 0.986061616799396 0.180184875113822 no 611 0.162051438707822 819 46497897 SGTC_573 3702-0553 84.7 µM 0.984978760900257 0.180456769997449 no 612 0.162317251859618 800 1222756 SGTC_1925 st057770 10.1 µM 0.984951978262187 0.180463498124772 no 613 0.16232382990023 730 5989122 SGTC_2284 7945075 39.21 µM 0.983492924053248 0.180830268217044 no 614 0.162682448077714 901 1245402 SGTC_881 0833-0569 170 µM 0.982073063590529 0.181187634219806 no 615 0.163031927309594 794 5418700 SGTC_2934 9036370 36.88 µM 0.981478762547251 0.181337345639818 no 616 0.163178351158755 844 6462800 SGTC_2881 9058953 51.95 µM 0.980824185965667 0.181502330788505 no 617 0.163339724560427 885 17122249 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.97933436932895 0.181878187219232 no 618 0.163707396876735 779 15053 SGTC_3175 9106517 49.47 µM 0.97848597940787 0.182092439531217 no 619 0.16391701119103 798 41468073 SGTC_2825 7998094 58.44 µM 0.977746385244496 0.182279345246901 no 620 0.164099887028835 775 2987815 SGTC_3141 9094609 49.47 µM 0.976838770175387 0.182508875948998 no 621 0.164324489361934 751 25236309 YDL196W YDL196W SGTC_1902 st060212 70.5 µM 0.976668515154784 0.182551952578103 no 622 0.164366643593047 843 688944 SGTC_2082 5219693 150 µM 0.976406789839202 0.182618184707344 no 623 0.164431459050333 806 2834649 SGTC_1526 st051518 75 µM 0.975631335927367 0.182814508919369 no 624 0.164623595041886 751 673993 SGTC_1152 3909-8331 15.9 µM 0.975162302571909 0.182933319550598 no 625 0.164739879088437 798 16001939 SGTC_619 1652-1634 108 µM 0.974744975592858 0.183039072963394 no 626 0.164843388672102 775 5400454 SGTC_414 piperonyl butoxide 100 µM 0.973102159182041 0.18345574399604 no 627 0.165251265515746 809 5794 A potent inhibitor of cytochrome P450. SGTC_1463 k081-0032 34.1 µM 0.970513932261937 0.184113399975225 no 628 0.165895191859067 710 977755 SGTC_1807 st050092 58.9 µM 0.970192630099795 0.184195143582551 no 629 0.165975241801224 793 5008496 SGTC_1245 0418-0076 17.2 µM 0.967360893344472 0.184916552104252 no 630 0.166681826257021 833 6790114 SGTC_220 paclitaxel 373.376 µM 0.966769351276129 0.185067473779433 no 631 0.166829674563632 754 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3354 9151612 71.43 µM 0.965670756726377 0.185347964028987 no 632 0.167104478484105 864 27261949 SGTC_589 1227-0070 34.1 µM 0.963134429456042 0.185996539776413 no 633 0.167740032843089 840 2841384 SGTC_2153 5569715 200 µM 0.961237886518799 0.186482431644933 no 634 0.168216285428682 833 2054701 SGTC_289 k017-0060 526 µM 0.959104044972497 0.187030058024993 no 635 0.168753166438844 810 5512909 SGTC_2468 5987765 72.9 µM 0.957281580443167 0.187498559824604 no 636 0.169212574907087 891 26772094 SGTC_2220 6782180 200 µM 0.956570965185465 0.187681434379504 no 637 0.169391924812063 760 833803 SGTC_2992 9074591 71.4286 µM 0.955262712384713 0.188018397072371 no 638 0.169722429467554 807 17741321 SGTC_1076 itraconazole 331 nM 0.954309713804092 0.18826409297307 no 639 0.169963446238816 882 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.953875761413368 0.188376037366418 no 640 0.170073267024861 921 5024745 SGTC_2423 st077119 87.2 µM 0.953708174502231 0.188419279859436 no 641 0.170115690590312 814 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1985 st071382 65.5 µM 0.953553172987848 0.188459280388897 no 642 0.170154934278579 860 6123237 SGTC_1627 st003713 25.6 µM 0.95335243339667 0.188511092116529 no 643 0.170205766673391 913 16195070 YER133W GLC7 SGTC_1926 methyl fluorone black 53.6 µM 0.951477966291161 0.188995323769808 no 644 0.170680899207533 779 72721 Reacts with homocysteine. SGTC_2235 salicylic acid 500 µM 0.950175409246557 0.189332264520928 no 645 0.171011565713899 849 338 A COX inhibitor and kinase inhibitor. SGTC_2381 9035592 200 µM 0.945564340114678 0.190528007770675 no 646 0.172185419855452 788 4749657 SGTC_18 0111-0177 500 nM 0.94494290428565 0.190689512418541 no 647 0.17234401297309 956 721752 SGTC_329 k048-0121 21.3 µM 0.94285700368613 0.191232230158762 no 648 0.172877024936132 840 6832902 SGTC_1383 3049-0032 20.7 µM 0.940827821733795 0.191761098246114 no 649 0.173396550435566 891 712864 SGTC_1695 st026914 34.495 µM 0.938524342043132 0.192362541060822 no 650 0.173987506716002 862 3289191 SGTC_3062 9077494 49.47 µM 0.938015921932494 0.192495445732427 no 651 0.174118113889225 840 16459633 SGTC_457 grayanotoxin iii 135 µM 0.93655344260115 0.192878061213574 no 652 0.174494155052711 894 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1825 st052143 62.6 µM 0.935348874419619 0.193193550307737 no 653 0.174804267696911 842 674173 SGTC_50 0929-0078 56.389 µM 0.935304576335934 0.193205158444212 no 654 0.174815678777258 802 1377751 SGTC_1172 0370-0043 85 µM 0.935288458085053 0.193209382273321 no 655 0.174819830917426 876 376585 SGTC_1959 st077091 55.8 µM 0.934169351507586 0.193502784826363 no 656 0.175108271278753 892 821356 YKL052C ASK1 SGTC_1731 st035964 63 µM 0.933241162682851 0.193746339453821 no 657 0.175347733076472 832 6739575 SGTC_731 3966-0296 387 µM 0.931765827665885 0.194133848402919 no 658 0.175728779206444 872 660956 SGTC_2448 5185112 27.17 µM 0.93112186784197 0.194303137683563 no 659 0.175895264001236 786 5718189 SGTC_1569 carminic acid 40.6 µM 0.929358480167007 0.194767170957068 no 660 0.176351668790706 904 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2691 st077356 60.2 µM 0.927615600105253 0.195226469455936 no 661 0.176803501314801 917 2839272 SGTC_2107 5363541 170.161 µM 0.927444257027041 0.195271658739755 no 662 0.176847960582363 917 244052 SGTC_3303 9125618 40.5795 µM 0.926870413738415 0.195423047972217 no 663 0.176996910100681 925 22695467 SGTC_1070 indatraline 8.81 µM 0.926524579751353 0.195514319045666 no 664 0.17708671470029 870 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.92569625588777 0.195733032080613 no 665 0.17730192709594 922 3256 An antibiotic and ribosome inhibitor. SGTC_1736 st036774 51 µM 0.925183194911506 0.195868576639529 no 666 0.177435311714378 912 1272247 SGTC_2011 4012611 177 µM 0.923506148640242 0.19631202937605 no 667 0.177871748815536 878 2049887 SGTC_1571 st070080 73.4 µM 0.923280045618137 0.196371863163169 no 668 0.177930641966767 888 4315245 SGTC_3180 9109287 49.47 µM 0.923010299370013 0.19644326074358 no 669 0.178000918972453 831 18891271 SGTC_857 0438-0306 1.35 µM 0.922566712941101 0.19656070528169 no 670 0.178116524620545 894 4686136 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.922021004654698 0.196705246085514 no 671 0.178258809756356 864 364106 SGTC_1953 st076800 12.1 µM 0.921270522031683 0.196904130224223 no 672 0.178454603642312 859 297591 SGTC_1461 k072-0203 53.8 µM 0.919713707679615 0.197317087004844 no 673 0.178861193726992 850 5418714 SGTC_2280 7785178 200 µM 0.919439264612978 0.197389939379665 no 674 0.178932929879621 867 2954328 SGTC_396 dithiazanine 1.25 µM 0.919204747998415 0.197452205952504 no 675 0.178994244077379 843 10578 An antihelmenthic. SGTC_1270 0831-1170 17.3 µM 0.919156400566548 0.197465044169369 no 676 0.179006886121673 949 6764716 SGTC_202 3594-0513 34.79 µM 0.918448421956242 0.197653099198381 no 677 0.17919207502624 856 708429 SGTC_2852 9023854 51.95 µM 0.917826996780628 0.197818252861705 no 678 0.179354723057399 880 19798528 SGTC_140 0062-0056 502.533 µM 0.916987849260951 0.198041401979367 no 679 0.179574503660743 968 3758964 SGTC_783 0848-0141 92.7 µM 0.916563098942591 0.198154411029103 no 680 0.179685814243921 847 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1153 4055-0057 267 µM 0.916084270015592 0.198281854903744 no 681 0.179811348704275 901 882706 SGTC_207 4185-0010 4.486 µM 0.914260013129984 0.198767847514555 no 682 0.18029011827432 987 3761753 SGTC_293 4049-0273 38.5 µM 0.91355880395915 0.198954844619134 no 683 0.18047436071296 842 1380311 SGTC_251 melphalan 456.522 µM 0.913488407725206 0.198973623604892 no 684 0.180492863817744 983 460612 A DNA alkylator. SGTC_2212 7123476 200 µM 0.912456992794595 0.199248887576092 no 685 0.180764099668744 831 1085715 SGTC_2110 5483698 200 µM 0.912231707592834 0.199309042184365 no 686 0.180823377922481 885 2848765 YHR062C RPP1 SGTC_2316 5844804 197.44 µM 0.911801796771498 0.199423865318085 no 687 0.180936532178159 1031 776813 SGTC_370 0180-0345 38.7 µM 0.909639174135153 0.200002075186925 no 688 0.181506415977868 826 3989527 SGTC_3195 9113082 49.47 µM 0.909471101692205 0.200047054068421 no 689 0.18155075261181 885 17018038 SGTC_1235 benzylparaben 21.5 µM 0.909018317804021 0.2001682565538 no 690 0.181670228363713 849 7180 SGTC_586 0957-0265 8.15 µM 0.908850166534202 0.200213279002476 no 691 0.181714610840659 823 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2924 9010168 62.78 µM 0.90858213889932 0.200285055895692 no 692 0.181785369083307 893 2993929 SGTC_2767 sibutramine 71.45 µM 0.907769743885677 0.200502706964066 no 693 0.181999943451597 924 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2205 7238770 200 µM 0.907637510351463 0.20053814746518 no 694 0.182034884701864 918 279867 SGTC_2309 7664088 163.95 µM 0.906141683248836 0.200939312683411 no 695 0.182430432509387 955 704922 SGTC_615 k087-0205 167 µM 0.90583939760298 0.201020440981669 no 696 0.182510432334932 855 9642773 SGTC_1080 nisoldipine 24.4 µM 0.905374015377377 0.201145380016254 no 697 0.182633638460482 911 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3220 9131269 49.47 µM 0.903608197288968 0.201619864504628 no 698 0.183101596545794 896 17722206 SGTC_2856 9022925 19.48 µM 0.903217549509511 0.201724924093146 no 699 0.183205222766137 891 4944862 SGTC_1488 4013-0813 75.9 µM 0.902468216382796 0.201926539133685 no 700 0.18340409895676 877 2910057 SGTC_1207 2099-0101 141 µM 0.898376594444578 0.203029553960059 no 701 0.184492405147399 975 5837381 SGTC_2982 9019404 25.97 µM 0.897421272947417 0.203287605586749 no 702 0.184747082673649 828 22333232 SGTC_1142 3253-1408 9.78 µM 0.896978878571664 0.203407171519108 no 703 0.18486509383578 902 256655 SGTC_2600 tangeritin 87.95 µM 0.894106245567917 0.204184578277115 no 704 0.185632523988861 863 68077 A bioactive flavone. SGTC_534 k292-0788 63.4 µM 0.891009322535981 0.205024662604255 no 705 0.186462084465079 1008 4146317 SGTC_2351 9026858 72.31 µM 0.89081002394071 0.205078795447747 no 706 0.186515548309616 860 1409300 SGTC_686 1319-0111 510 µM 0.889916075033768 0.205321711461396 no 707 0.186755475835539 964 4562600 SGTC_2784 7567673 72.73 µM 0.88726312675746 0.206043612370065 no 708 0.187468626367804 952 3471247 SGTC_2880 9042983 58.44 µM 0.886999230951645 0.206115503986519 no 709 0.187539657264863 893 6464714 SGTC_2022 5136654 200 µM 0.886897401968388 0.206143248646986 no 710 0.187567070271076 900 1713771 SGTC_795 0685-0265 78 µM 0.885060291961388 0.206644173909558 no 711 0.18806205709575 955 302754 SGTC_2217 6934799 96.0675 µM 0.884045695326196 0.206921132955811 no 712 0.188335773039478 944 675606 SGTC_750 4073-0104 132 µM 0.883524880893473 0.207063387321229 no 713 0.188476372768165 787 22330957 SGTC_2771 fluoxetine 41.05 µM 0.882650778512075 0.207302268156126 no 714 0.188712492003589 890 3386 A selective serotonin reuptake inhibitor. SGTC_2078 5212016 200 µM 0.882351763166644 0.207384022560794 no 715 0.188793306156828 905 1899708 SGTC_1608 st001473 40.5 µM 0.880064720748077 0.208009957735837 no 716 0.189412124757052 891 7292267 SGTC_1919 st067113 52.3 µM 0.879027981680924 0.208294067353161 no 717 0.189693052113646 904 1268243 SGTC_355 1311-2252 105 µM 0.878826006552614 0.20834944356958 no 718 0.189747811549519 890 5338538 SGTC_3019 9081971 49.47 µM 0.877799382436358 0.208631050861623 no 719 0.190026299837161 997 16451803 SGTC_2419 paclitaxel 166.5 µM 0.875146704998345 0.209359729459967 no 720 0.190747043586135 970 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1715 st032160 10.2275 µM 0.873614089510125 0.209781413822106 no 721 0.19116422531543 906 5289825 SGTC_1191 1487-1166 10.6 µM 0.873249813527484 0.209881714240028 no 722 0.191263464362147 1040 3955771 SGTC_1748 st037455 53.6035 µM 0.87076132633923 0.210567652471577 no 723 0.191942242820444 912 580690 SGTC_2234 tolnaftate 200 µM 0.869378100369138 0.210949499511285 no 724 0.192320178682431 929 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_592 k241-0073 46.5 µM 0.86908168175074 0.211031380270642 no 725 0.192401227679242 991 4230158 SGTC_696 1560-0013 611 µM 0.867754471074052 0.211398228740279 no 726 0.19276437959753 944 1650269 SGTC_325 2810-4341 181 µM 0.866393138331948 0.211774896483395 no 727 0.193137302764797 964 774970 SGTC_1342 1486-1464 234 µM 0.864329203392174 0.212346715974665 no 728 0.193703535988236 955 3253938 SGTC_1276 0871-0068 94.2 µM 0.863403448313279 0.212603492084499 no 729 0.193957842085625 940 3414906 SGTC_378 3970-0959 8.33 µM 0.862734311916686 0.212789202882943 no 730 0.194141781316629 943 6615653 SGTC_1012 4112-3522 18 µM 0.86129897276966 0.213187883365426 no 731 0.194536700655462 992 3112398 SGTC_791 1348-1292 225 µM 0.861282944584683 0.213192337819799 no 732 0.194541113410161 1014 5437054 SGTC_401 neomycin 50 µM 0.860840698503883 0.213315265534212 no 733 0.194662893174796 923 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2938 9059746 27.26 µM 0.859770966651381 0.213612781424744 no 734 0.19495765323865 902 6471769 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.859659437677895 0.213643813989161 no 735 0.194988400187388 863 61125 An anti-inflammatory. SGTC_2533 agelasine 13.65 µM 0.859527308523416 0.213680581883835 no 736 0.195024830127617 984 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2815 7968870 71.43 µM 0.859173790808274 0.213778974223638 no 737 0.195122320475737 961 2977326 YHR190W ERG9 SGTC_3151 9099821 49.47 µM 0.85717630327519 0.214335417769501 no 738 0.195673728280899 947 17174189 SGTC_2492 derrusnin 100 µM 0.855506325888696 0.214801272122944 no 739 0.196135451942274 898 1715307 Part of coumarin class of compounds. SGTC_2002 4023503 131 µM 0.854373884160475 0.215117510776405 no 740 0.196448930688534 1065 4736863 YCR052W RSC6 SGTC_1120 ficusin 1.78878 µM 0.85262244726914 0.215607138076452 no 741 0.196934355148522 964 6199 A DNA cross-linker. SGTC_1449 4112-4002 201 µM 0.85124672042058 0.215992185566367 no 742 0.197316157345356 902 2059539 SGTC_3338 9144300 39.5675 µM 0.847321226550284 0.217093066238934 no 743 0.198408049184679 964 4901274 SGTC_2855 9016525 58.44 µM 0.846999767831455 0.217183360754102 no 744 0.198497625428172 1014 43811474 SGTC_2439 5492030 7.2 µM 0.846850915330895 0.217225179269475 no 745 0.198539112260597 960 5722370 SGTC_2847 9005661 71.43 µM 0.84546119182672 0.217615831553626 no 746 0.19892669583403 885 2991449 SGTC_1871 st057448 67.3 µM 0.844420901916977 0.217908522938322 no 747 0.199217123190202 1000 691747 SGTC_2187 6125751 200 µM 0.842931329462302 0.218328017476656 no 748 0.199633425274392 973 874498 SGTC_1460 k062-0059 9.15 µM 0.842769877304484 0.218373513685575 no 749 0.199678578953326 967 1373085 SGTC_2845 9003024 42.97 µM 0.84179956788563 0.218647055822843 no 750 0.199950076930171 1000 2990173 SGTC_1440 4100-1550 40 µM 0.84156977803323 0.218711865277783 no 751 0.200014405903629 1016 742806 SGTC_2643 anethole 100 µM 0.841401128036334 0.218759438008538 no 752 0.20006162687609 1020 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1205 4161-2785 76 µM 0.840858364962121 0.218912580836565 no 753 0.20021364271751 862 3498106 SGTC_1024 4507-0395 26 µM 0.840621581225416 0.218979409655839 no 754 0.200279982306376 932 4201836 SGTC_1677 st019204 53.9 µM 0.837538198078476 0.21985072105131 no 755 0.201145057572861 912 3945625 SGTC_3317 9138495 8.753 µM 0.834666548655341 0.220663986731944 no 756 0.201952740552488 1016 17020139 SGTC_1020 4335-0961 93.3 µM 0.834097205369907 0.220825432094605 no 757 0.202113104911512 917 669075 SGTC_893 0958-0369 48.9 µM 0.834058626562587 0.220836374108688 no 758 0.202123973986224 1020 6819948 SGTC_770 0389-1121 67.2 µM 0.833920029329294 0.220875686668633 no 759 0.202163024830316 1040 6753108 SGTC_2119 5528445 120.635 µM 0.83170508305062 0.22150449089677 no 760 0.202787715410879 984 791935 SGTC_1636 st007707 68.9 µM 0.829799772837596 0.222046209878874 no 761 0.203325999645314 1015 403051 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.828393126507517 0.222446633279391 no 762 0.203723948957383 1042 5393153 SGTC_1193 1488-0126 41.5 µM 0.827579174629283 0.222678525106457 no 763 0.20395443312477 1055 1384710 SGTC_1757 st041620 31.8375 µM 0.826963249454604 0.222854091415847 no 764 0.204128945929615 1014 5289815 SGTC_86 0417-1630 471.922 µM 0.825264271515618 0.223338784949152 no 765 0.204610785681043 1104 3634867 SGTC_2683 piperine 63.03 µM 0.823906833989141 0.223726472749945 no 766 0.20499624852528 974 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_71 0417-1750 47.813 µM 0.823633827234346 0.223804490398251 no 767 0.205073824612454 1009 6811472 SGTC_145 3737-0113 38.366 µM 0.8225633541954 0.224110550624 no 768 0.205378172595738 1105 6849351 SGTC_2388 9080168 200 µM 0.821950880377834 0.224285770609553 no 769 0.205552426642445 935 15943073 SGTC_2224 6650123 117.647 µM 0.820370454024454 0.224738267049495 no 770 0.20600247675858 988 2908370 SGTC_1590 st077108 57.8 µM 0.820280785115716 0.224763955924632 no 771 0.206028028832918 1020 5489485 SGTC_250 brefeldin a 552.239 µM 0.819706911026584 0.224928402164485 no 772 0.206191604637946 912 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_560 2332-1943 155 µM 0.819636766859367 0.224948506972075 no 773 0.206211603655714 992 21177716 SGTC_712 r015-0009 80.6 µM 0.81930966510359 0.225042274728737 no 774 0.206304879819104 951 6813872 YLR060W FRS1 SGTC_1241 0364-0022 50.8 µM 0.818654249656551 0.22523022429428 no 775 0.206491852972628 1005 4563895 SGTC_3201 9113999 49.47 µM 0.818154973519303 0.225373458364905 no 776 0.206634350939662 963 16649224 SGTC_2713 st079149 53.4 µM 0.817311539000522 0.225615542900712 no 777 0.206875207094253 1010 3103253 SGTC_3093 9117344 49.47 µM 0.815910772022988 0.22601791922206 no 778 0.207275585356789 958 24824913 SGTC_349 k015-0014 24 µM 0.81471989445243 0.226360322718303 no 779 0.207616331471808 951 2196908 SGTC_527 4476-4215 268 µM 0.814217042552852 0.226504991627143 no 780 0.207760311948616 995 4418754 SGTC_953 1188-0045 9.7 µM 0.811490239334688 0.227290392760399 no 781 0.208542097960162 1039 6144426 SGTC_114 0364-0001 490.298 µM 0.810456749451713 0.227588469408537 no 782 0.20883885656715 1016 4003655 SGTC_2466 5983409 37.09 µM 0.809747670726095 0.227793107425927 no 783 0.20904260686666 982 2879657 SGTC_1195 1502-0147 41.1 µM 0.808977487969281 0.228015497160007 no 784 0.209264047691883 1059 817940 SGTC_2451 5856223 45.7 µM 0.808685958774595 0.228099707861608 no 785 0.209347903373166 998 2179896 SGTC_2796 7949634 45.45 µM 0.808363871187535 0.228192765948054 no 786 0.209440571882922 961 2971588 SGTC_2380 9035439 200 µM 0.806494610769455 0.228733256998931 no 787 0.2099788570983 1082 6462575 SGTC_2052 5265182 7.135 µM 0.80638883563529 0.228763863033876 no 788 0.210009341124192 1023 1239884 SGTC_161 4065-0411 162.148 µM 0.805594798913579 0.228993690953971 no 789 0.21023826276429 1027 1906281 YLR208W SEC13 SGTC_342 k048-0088 23.3 µM 0.804212534685953 0.229394085759101 no 790 0.210637120443921 1039 6820570 SGTC_889 0919-1524 82.7 µM 0.801369540418297 0.230218836473882 no 791 0.211458871680556 994 3905452 SGTC_500 h-89 112 µM 0.800046080436625 0.230603336349228 no 792 0.211842049716214 1070 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_399 oxolinic acid 75 µM 0.799237441724289 0.230838443622247 no 793 0.212076372648333 1009 4628 A DNA gyrase inhibitor. SGTC_1137 ixabepilone 100 µM 0.79796840354071 0.231207679247771 no 794 0.21244441303747 1022 154225 A novel microtubule stabilizer. SGTC_517 1365-0151 113 µM 0.797408964828397 0.231370556483808 no 795 0.212606777215581 1004 768657 SGTC_3272 9137413 49.47 µM 0.795841537608609 0.231827244175796 no 796 0.213062072586243 1054 17614870 SGTC_3198 9112019 49.47 µM 0.795745590870659 0.231855215645486 no 797 0.213089960990731 1041 45595555 SGTC_2947 9072639 7.68 µM 0.794963665287206 0.232083241437651 no 798 0.213317319143456 1109 16488146 SGTC_1203 3992-3522 103 µM 0.794836101913547 0.23212045341613 no 799 0.213354423776566 1097 5322312 SGTC_2270 7924575 90.91 µM 0.794643302667162 0.232176701892186 no 800 0.213410510848682 1041 1262135 SGTC_1746 st038117 42 µM 0.7942549303346 0.232290031129742 no 801 0.213523518018296 1010 2898218 SGTC_973 1325-0077 65.9 µM 0.79417059302059 0.232314645300567 no 802 0.213548062791119 1090 2835149 SGTC_1176 0848-0131 83.3 µM 0.79389832578631 0.232394117447259 no 803 0.213627312216914 1118 6769040 SGTC_536 3852-0578 10.6 µM 0.792396596740184 0.232832729106336 no 804 0.214064731592722 1075 2869208 SGTC_2149 5554786 194.827 µM 0.791796633085309 0.233008089650776 no 805 0.214239632927858 1081 745063 YPR165W RHO1 SGTC_2625 euphol 100 µM 0.789089679739551 0.233800203601175 no 806 0.215029796687986 1051 6708538 A triterpene alcohol. SGTC_3004 9076122 71.4286 µM 0.788694285110114 0.233916029531882 no 807 0.215145354450397 1050 44782551 SGTC_3009 9080819 71.4286 µM 0.788202762264303 0.234060059340601 no 808 0.215289056829078 1065 17027216 SGTC_1022 4477-0945 21.3 µM 0.780173406987249 0.236419824684606 no 809 0.217644406488687 1048 4648966 SGTC_2429 5902844 64.44 µM 0.778768758192309 0.236833981805425 no 810 0.218057972206617 1097 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1358 1509-0022 2.48 µM 0.777699796938364 0.237149429433376 no 811 0.218373005969822 1085 3258434 SGTC_2957 9076800 11.52 µM 0.777424876606908 0.237230594994995 no 812 0.218454070152826 1010 16459615 SGTC_3140 9094243 49.47 µM 0.776441797600483 0.237520957184478 no 813 0.218744086773893 1146 19291112 SGTC_2324 6149169 200 µM 0.77588592595879 0.237685225709578 no 814 0.218908171628284 1039 2888231 SGTC_481 bay k-8644 50 µM 0.775708860060902 0.237737564461679 no 815 0.218960453654056 1021 2303 A calcium channel antagonist. SGTC_1182 1222-0449 220 µM 0.775368497815443 0.237838189590672 no 816 0.219060972157244 1035 658318 SGTC_813 k007-0158 173 µM 0.775332429868015 0.23784885413326 no 817 0.219071625587009 1123 6523916 SGTC_427 1354-0053 47.3 µM 0.775275129227011 0.237865797281364 no 818 0.21908855115372 1043 6813657 SGTC_559 1550-0661 158 µM 0.773577016314161 0.238368210284968 no 819 0.219590484035855 1080 5830875 SGTC_532 1548-0774 215 µM 0.772861988610597 0.238579936048009 no 820 0.219802031321634 1112 5932993 SGTC_439 amiodarone 34.4 µM 0.772683205967086 0.238632891185412 no 821 0.219854944028141 1059 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_96 0929-0093 37.281 µM 0.77142450125816 0.239005899538908 no 822 0.220227678511791 1029 6991579 SGTC_467 ro 31-8220 72.8 µM 0.770816581305943 0.239186166464138 no 823 0.220407828763015 1066 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_515 4092-1064 102 µM 0.77077085910599 0.239199727503337 no 824 0.220421381437989 1119 717353 SGTC_442 cape 100 µM 0.77056228547602 0.239261595017299 no 825 0.220483211525782 1046 5281787 SGTC_2196 6573537 42.6665 µM 0.769821503226735 0.239481397930892 no 826 0.220702891187455 1089 2903087 SGTC_1866 st057638 64 µM 0.769348327369706 0.23962185508271 no 827 0.220843277514653 1055 688802 SGTC_1722 st034304 3.6505 µM 0.768760657735819 0.239796361060548 no 828 0.221017704110249 1108 4036148 YLR033W RSC58 SGTC_1676 st018489 23.4 µM 0.766604894342077 0.240437099022384 no 829 0.221658232309823 1047 3696235 SGTC_788 1182-0090 188 µM 0.765623051107588 0.240729232129043 no 830 0.221950312327305 1153 5715185 SGTC_2430 5571206 200 µM 0.76287760751274 0.241547123011762 no 831 0.222768195900299 1166 1731771 SGTC_2940 9060638 45.86 µM 0.762296007222993 0.241720580150513 no 832 0.222941678198396 1062 4027022 SGTC_2555 cholic acid 100 µM 0.761540797907177 0.241945915501122 no 833 0.223167060162487 1076 6708657 Influences liver metabolism. SGTC_1318 1280-3875 124 µM 0.76145532794011 0.241971424752382 no 834 0.223192575681827 1083 373245 SGTC_91 0417-1751 58.384 µM 0.761406128228381 0.241986109493638 no 835 0.223207264122772 1239 6795624 SGTC_3342 9147791 14.508 µM 0.760648048389669 0.242212436266493 no 836 0.223433656358298 1076 1838168 SGTC_888 0916-0002 6.97 µM 0.758715646182475 0.242789878811747 no 837 0.224011337651835 1114 2802138 YIL048W NEO1 SGTC_1261 0712-0010 12.7 µM 0.756513936870109 0.243448703009993 no 838 0.224670559810436 1120 2840123 SGTC_684 1140-0066 328 µM 0.755694032773783 0.243694291999325 no 839 0.22491633130358 1133 6813534 SGTC_2101 5377231 179.231 µM 0.754334864759308 0.244101703239611 no 840 0.225324086123517 1097 2844213 SGTC_694 1315-0438 43.2 µM 0.753902292122395 0.2442314441025 no 841 0.225453947079299 1027 6793154 SGTC_138 0850-0259 40.9225 µM 0.753237781629462 0.244430822137351 no 842 0.225653519708726 1140 6813004 SGTC_2828 7998861 71.43 µM 0.753088818107065 0.244475528803419 no 843 0.225698271677921 1026 2988188 SGTC_2128 5255449 168.493 µM 0.752428484433385 0.244673760001771 no 844 0.225896711112646 1144 736008 SGTC_2684 capsaicin 100 µM 0.752059616833983 0.244784531179187 no 845 0.226007603880491 1093 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_456 gingerol 170 µM 0.751907835407354 0.244830119077542 no 846 0.226053242907568 1175 442793 A herb. SGTC_1714 st033236 13.627 µM 0.751247263337866 0.245028576618939 no 847 0.226251930416588 1123 2916566 SGTC_2279 7948423 32.93 µM 0.750235216853243 0.245332796396138 no 848 0.226556526025852 1097 1247112 SGTC_886 0866-0150 153 µM 0.747784436072306 0.246070338035508 no 849 0.227295095694619 1152 271463 SGTC_3232 9132874 49.47 µM 0.7472232737216 0.246239382266671 no 850 0.227464398813861 1107 3784940 SGTC_625 k213-0058 121 µM 0.745346673240162 0.246805140327114 no 851 0.228031086274169 1196 3655420 SGTC_2638 epoxomicin 18 µM 0.743993713090593 0.247213462452343 no 852 0.228440139285164 1103 9915668 A protesome inhibitor. SGTC_2409 alverine citrate 63.97 µM 0.743015197981342 0.247509002367746 no 853 0.228736239582478 1109 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2838 9002687 71.43 µM 0.742773645494335 0.24758198725938 no 854 0.228809366914194 1077 6457060 SGTC_1744 st037937 38.9 µM 0.742724818463776 0.247596741704524 no 855 0.228824150349537 1149 1016152 SGTC_682 0kpi-0099 17 µM 0.742154017726187 0.24776925985562 no 856 0.228997012333188 1145 1714895 YML126C ERG13 SGTC_3213 9129884 49.47 µM 0.740877833789132 0.248155204245471 no 857 0.229383758317789 1093 17190742 SGTC_721 1187-1332 279 µM 0.740569438697913 0.248248517373925 no 858 0.229477271969851 1042 25730 SGTC_1144 3486-0183 12.5 µM 0.738219104410946 0.24896028768068 no 859 0.230190657696234 1139 6744069 SGTC_1057 3448-5381 134 µM 0.737723255712009 0.249110588068705 no 860 0.230341318589071 1150 5497911 SGTC_398 bronopol 33.3 µM 0.735661060690061 0.249736192797175 no 861 0.230968496316267 1096 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3149 9097855 49.47 µM 0.734889431576128 0.249970494969975 no 862 0.231203417630219 1113 25236625 YMR079W SEC14 SGTC_2986 9022445 71.43 µM 0.73469725957807 0.250028865386762 no 863 0.231261944831772 1113 6459286 SGTC_274 sirtinol 40.1 µM 0.734213209146855 0.250175923145632 no 864 0.231409402083454 1153 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2519 cryptotanshinone 88.04 µM 0.733192627930046 0.250486132809251 no 865 0.231720475523154 1127 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2008 4012253 172 µM 0.733001597452156 0.250544219910889 no 866 0.23177872754276 1150 603940 SGTC_604 1000-0114 314 µM 0.731719816600753 0.250934158658268 no 867 0.232169799279305 1170 1572745 SGTC_1054 3429-0080 167 µM 0.729449024966584 0.251625758471165 no 868 0.232863519234208 1162 1162877 SGTC_1864 st057645 30.4 µM 0.729040465639489 0.25175029743784 no 869 0.232988454989759 1176 688666 SGTC_1030 k029-0042 36.7 µM 0.727634610988119 0.252179085199826 no 870 0.233418643854632 1151 6080581 SGTC_1496 4469-0713 57.4 µM 0.72741056519595 0.252247455065561 no 871 0.233487242128216 1134 746691 SGTC_2079 5212404 121 µM 0.726883530743358 0.252408323551841 no 872 0.233648653460857 1151 758462 SGTC_375 3970-0961 9.27 µM 0.725268100403287 0.252901743426695 no 873 0.234143785778395 1115 2898222 SGTC_2432 5630864 12.22 µM 0.724570495912857 0.253114977811397 no 874 0.23435778230248 1115 5714970 SGTC_297 0986-0032 24 µM 0.724148431577573 0.253244034679134 no 875 0.234487306912598 1133 2847425 SGTC_3260 9137109 49.47 µM 0.722549709546047 0.253733198035847 no 876 0.234978287375145 1015 17478346 SGTC_2620 irigenin 100 µM 0.722269082257428 0.253819113143087 no 877 0.235064528850234 1174 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3109 9122853 49.47 µM 0.721941412217069 0.253919449889971 no 878 0.235165249475547 1188 1234709 SGTC_3025 9087895 49.47 µM 0.721107791990682 0.254174808851784 no 879 0.235421598658707 1177 17173641 SGTC_390 dec-rvkr-cmk 16.7 µM 0.720411226255559 0.254388287794554 no 880 0.235635920001389 1189 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2978 9011784 42.97 µM 0.719799602124542 0.254575811839117 no 881 0.235824194968321 1224 2994934 SGTC_1168 k815-0004 80.5 µM 0.718580390333671 0.254949838275449 no 882 0.23619974968124 1163 642433 SGTC_1732 st034308 51.822 µM 0.718387893286151 0.255008918262917 no 883 0.236259074784986 1070 830119 SGTC_1424 4048-1941 275 µM 0.715118208936533 0.256013522349588 no 884 0.237268001626823 1208 X1424 SGTC_967 1306-0166 352 µM 0.713654376312838 0.256463950192709 no 885 0.237720462320896 1138 4437607 SGTC_719 2810-4230 27.3 µM 0.710195359535506 0.257529943362868 no 886 0.238791499057867 1149 721079 SGTC_1439 4092-1168 46 µM 0.710123215519077 0.257552201042594 no 887 0.238813865522205 1156 2886240 SGTC_3088 9117578 49.47 µM 0.709222585355745 0.257830145126558 no 888 0.23909318000821 1232 678341 SGTC_832 4083-0019 164 µM 0.705888164813762 0.258860536252118 no 889 0.240128844088872 1269 1990758 SGTC_774 k060-0086 136 µM 0.705872632543918 0.25886534096109 no 890 0.240133674094744 1216 5911235 SGTC_2341 7987486 176.74 µM 0.70562476695141 0.258942021254105 no 891 0.240210759000419 1189 1258686 SGTC_1910 st062352 60.4 µM 0.705515601527044 0.258975796657612 no 892 0.240244713154679 1160 2245730 SGTC_3319 9138450 16.7555 µM 0.703964352676127 0.259455993803622 no 893 0.240727486748759 1138 2029690 SGTC_134 0269-0018 6.916 µM 0.703318036923931 0.259656199839713 no 894 0.240928786310873 1103 4378915 SGTC_1618 st003135 44.5 µM 0.701830023349093 0.260117437414746 no 895 0.241392586403434 1153 1270615 SGTC_1390 3413-2614 145 µM 0.70038465891819 0.260565859125797 no 896 0.241843557135027 1216 3421432 SGTC_3205 9113483 49.47 µM 0.699583168870908 0.260814691393822 no 897 0.242093828369503 1185 17018033 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.699565006595494 0.260820331507805 no 898 0.242099501301994 1199 23847180 SGTC_666 0272-0154 136 µM 0.699491043344404 0.260843300707802 no 899 0.242122604247045 1213 6870312 SGTC_1623 st003709 20.3 µM 0.699276467087891 0.260909942997755 no 900 0.242189635423453 1190 16192618 SGTC_3270 9137563 49.47 µM 0.698399484092588 0.261182404093091 no 901 0.242463699461588 1136 17015724 SGTC_3194 9111903 49.47 µM 0.697365091316759 0.261503957095211 no 902 0.242787171101505 1201 17087251 SGTC_2813 7971799 71.43 µM 0.694488726451147 0.262399175667538 no 903 0.243687884157628 1195 2234054 SGTC_2514 salinomycin 42.74 µM 0.694428586861629 0.26241790980376 no 904 0.243706735674964 1234 23682228 A polyether potassium ionophore. SGTC_2201 6605497 169.863 µM 0.693211882651947 0.262797073426091 no 905 0.244088296086345 1192 670741 SGTC_876 0720-0963 56.8 µM 0.691623229251428 0.263292569640027 no 906 0.244586984956518 1226 765861 SGTC_733 4069-0007 56.1 µM 0.689653924840712 0.263907451356798 no 907 0.245205923651268 1230 5717425 YNL287W SEC21 SGTC_215 1287-0124 461.5 µM 0.687924073744043 0.264448171110267 no 908 0.245750297847435 1205 5560863 SGTC_1880 MG-132 525 µM 0.687261158682883 0.264655535547815 no 909 0.245959085250346 1151 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2167 5876490 200 µM 0.687099925962758 0.264705982763599 no 910 0.246009880442389 1236 686534 SGTC_2975 9084847 53.72 µM 0.6858893253284 0.265084917049482 no 911 0.24639145104768 1199 27211724 SGTC_607 4491-0986 66.8 µM 0.68557506758179 0.265183328981091 no 912 0.246490554139542 1233 698981 YDR232W HEM1 SGTC_3341 9147222 25.867 µM 0.682318272742781 0.266204307483305 no 913 0.247518860605556 1191 1939759 SGTC_1824 st053723 68.6 µM 0.681843857410139 0.266353198686065 no 914 0.247668844413217 1201 675225 SGTC_3064 1327-0027 10 µM 0.681729696986072 0.266389033249869 no 915 0.247704942849551 1112 16000455 YPR107C YTH1 SGTC_2602 kawain 100 µM 0.680530611813582 0.266765569262383 no 916 0.248084272827249 1209 5369129 SGTC_1979 st071809 45.3 µM 0.679691400467632 0.267029257820344 no 917 0.248349941127111 1278 4976333 SGTC_2069 5228469 200 µM 0.679019243604587 0.267240551084631 no 918 0.248562834484395 1189 2835210 SGTC_1375 2910-0797 186 µM 0.678164931520272 0.267509226763798 no 919 0.248833562424366 1218 742508 SGTC_1243 0416-0003 5.65 µM 0.676317274828806 0.268090768422234 no 920 0.249419613588049 1222 2141977 SGTC_2872 9044037 25.97 µM 0.675743988763091 0.268271336907771 no 921 0.249601601012091 1217 6465195 SGTC_2385 9074692 200 µM 0.67546880238511 0.268358034364728 no 922 0.249688982903618 1212 17046906 SGTC_39 0986-0283 58.349 µM 0.673939084216595 0.268840228751641 no 923 0.250175021239867 1264 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1996 st072960 66.8 µM 0.673411864758417 0.269006518473482 no 924 0.250342651216299 1224 1719405 SGTC_2376 9072922 81.32 µM 0.673102336225077 0.269104170582658 no 925 0.250441093869982 1261 17087968 SGTC_1992 st073643 23.3 µM 0.67244120019992 0.269312809705499 no 926 0.250651430686992 1227 3161292 SGTC_873 0591-4978 488 µM 0.671936907774781 0.269472007159879 no 927 0.250811931451727 1300 3305145 SGTC_335 4077-0256 27.6 µM 0.670343197747302 0.269975427071961 no 928 0.251319517805276 1252 3121989 SGTC_2951 9072950 58.06 µM 0.668796697468161 0.27046438394726 no 929 0.251812586856256 1253 16488155 SGTC_1931 st074438 57.1 µM 0.66731381715082 0.270933641314975 no 930 0.252285851218841 1216 2787313 SGTC_2173 5763948 167 µM 0.666785603223282 0.271100892645845 no 931 0.252454545007472 1254 2867177 SGTC_1429 4049-0205 9.46 µM 0.66652631663893 0.271183010844559 no 932 0.252537374180786 1262 22774478 SGTC_3119 9125183 49.47 µM 0.665718696187777 0.271438870347766 no 933 0.252795460490922 1111 22695334 SGTC_653 0203-0016 55.2 µM 0.664456026647738 0.271839133259892 no 934 0.253199242145084 1264 295302 SGTC_166 k072-0058 166.424 µM 0.660987401210281 0.272940187616133 no 935 0.254310196626007 1259 5846229 SGTC_1029 k015-0030 64.7 µM 0.660110146597397 0.273219006675842 no 936 0.254591573899789 1284 2208316 SGTC_814 3342-0569 96 µM 0.659516022762936 0.273407917995911 no 937 0.254782230247013 1286 4346283 SGTC_1725 st036284 20.55 µM 0.65418317853812 0.275106472333413 no 938 0.256496898829646 1279 707914 SGTC_2244 6635614 200 µM 0.651915019502516 0.275830471380057 no 939 0.257227997598181 1200 836499 SGTC_1169 aniline yellow 25.8 µM 0.651879099889091 0.275841944489344 no 940 0.257239584323339 1241 6051 A DNA damaging agent. SGTC_630 4356-0227 183 µM 0.651830179783017 0.275857570472362 no 941 0.257255365102807 1284 779312 SGTC_2485 5633444 17.78 µM 0.650647348097643 0.276235521028584 no 942 0.257637079258684 1245 5724239 SGTC_2395 5646831 180.19 µM 0.65061542444415 0.276245725123558 no 943 0.257647385483773 1297 6808628 SGTC_1706 st031321 9.9705 µM 0.650330919858181 0.276336672501842 no 944 0.257739244334147 1282 6103185 SGTC_1784 st039334 36.3 µM 0.649880656904128 0.276480637751095 no 945 0.257884656822103 1330 3496984 SGTC_2693 st077581 40.7 µM 0.649534375226495 0.276591381461111 no 946 0.257996517491852 1285 25238761 SGTC_2229 7354935 190 µM 0.64883136331061 0.276816277272442 no 947 0.258223691458694 1216 318112 SGTC_2734 clemastine 41.6 µM 0.648666053619388 0.276869173387373 no 948 0.258277125320112 1260 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1031 k035-0009 16 µM 0.647424090141388 0.277266737486125 no 949 0.258678754441107 1285 5180959 SGTC_296 1222-0039 74.9 µM 0.64697410972783 0.277410849292669 no 950 0.258824349934135 1234 5984176 SGTC_2505 galangin 7.89 µM 0.644424142629771 0.278228198900889 no 951 0.259650216620132 1227 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1660 st012960 28.1 µM 0.644291295874459 0.278270812881764 no 952 0.25969327940997 1252 24207266 SGTC_2773 thioridazine 9.09 µM 0.643735956799479 0.278448986482299 no 953 0.259873334625523 1288 5452 An antipsychotic. SGTC_2647 atorvastatin 60.16 µM 0.643633492910681 0.278481866813401 no 954 0.259906563090458 1277 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_263 alizarin 107.927 µM 0.643154274109306 0.27863567168647 no 955 0.260062000151489 1280 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2794 7785382 27.27 µM 0.642457214683586 0.278859466142381 no 956 0.260288180460534 1256 2205081 SGTC_680 0417-1641 114 µM 0.64231544462019 0.278904992839762 no 957 0.260334194099019 1261 2835990 SGTC_1511 0906-3109 28.5 µM 0.641988356672538 0.27901004456408 no 958 0.260440371471422 1312 2882180 SGTC_2264 7948757 110.76 µM 0.640383998140015 0.279525599268496 no 959 0.260961491728088 1259 2971411 SGTC_549 1661-1316 519 µM 0.637475823762377 0.280461307877779 no 960 0.261907476379655 1305 2857282 SGTC_3279 9140807 49.47 µM 0.636822566242047 0.2806717026321 no 961 0.262120212669837 1312 45595718 SGTC_1889 st059080 5.18 µM 0.636731212504424 0.280701131028992 no 962 0.262149969487193 1284 176925 Isolated from Daphnopsis sellowiana. SGTC_937 3122-0005 46.7 µM 0.636541282058757 0.280762319383702 no 963 0.26221184141326 1273 759535 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.636336923016004 0.280828163285816 no 964 0.262278421967762 1285 4330530 SGTC_1820 st053765 18.6 µM 0.636043804731903 0.280922618195043 no 965 0.26237393556365 1252 3690829 SGTC_3157 9099274 49.47 µM 0.63539670623073 0.281131194613049 no 966 0.262584857872385 1261 17217662 SGTC_497 capsazepine 133 µM 0.635010188063983 0.281255814988975 no 967 0.262710885181641 1240 2733484 A calcium channel blocker. SGTC_341 1486-1430 230 µM 0.633982377200257 0.281587329311 no 968 0.263046161532115 1246 2054753 YPL210C SRP72 SGTC_1104 tacrolimus 29.8 µM 0.633110543666172 0.281868681712814 no 969 0.263330728721853 1318 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_318 1488-0629 67.2 µM 0.632766925321278 0.281979609174591 no 970 0.263442929207556 1285 3662576 SGTC_3235 9132602 49.47 µM 0.631785869740513 0.282296430882 no 971 0.263763404068567 1323 4912240 SGTC_2607 solasodine 47.35 µM 0.630108318413946 0.282838575165357 no 972 0.264311858799536 1300 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.630108119979521 0.282838639324165 no 973 0.264311923709554 1353 165506 SGTC_956 1185-0240 191 µM 0.629071658286677 0.283173848621724 no 974 0.264651072085418 1319 1416193 SGTC_2656 pseudo-anisatin 100 µM 0.628180795667086 0.283462120943149 no 975 0.264942754680816 1307 6708809 A neurotoxin. SGTC_2989 9073649 71.4286 µM 0.62688830898329 0.283880603837708 no 976 0.26536622563267 1288 21367202 SGTC_2221 6807166 181.081 µM 0.626825961378422 0.2839007982945 no 977 0.265386661913429 1260 674925 SGTC_2659 sanguinarine 24.21 µM 0.626136125431129 0.284124282782647 no 978 0.265612829445648 1262 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2848 9016370 25.97 µM 0.625791517156318 0.2842359561994 no 979 0.265725848276282 1326 7894410 SGTC_1878 temozolomide 1 mM 0.623666589885845 0.284925021251616 no 980 0.266423284456798 1284 5394 DNA alkylating agent. SGTC_1550 gossypolone 36.6 µM 0.623324119420231 0.285036151061403 no 981 0.266535775506173 1300 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_385 1494-0393 12.4 µM 0.623158056543829 0.28509004500388 no 982 0.266590330716879 1332 3090647 SGTC_2055 5235184 200 µM 0.621079916696779 0.285764893649768 no 983 0.267273521265233 1324 2836034 SGTC_2414 st077232 92.9 µM 0.621044399663583 0.285776433941098 no 984 0.26728520519945 1271 729801 SGTC_3231 9132313 49.47 µM 0.618993174685013 0.286443299324591 no 985 0.267960427624269 1324 4905967 SGTC_331 k048-0133 24.5 µM 0.617913689560655 0.28679454265329 no 986 0.268316117274881 1288 6813582 SGTC_2781 5567276 71.43 µM 0.617583368682151 0.286902063378946 no 987 0.268425005226042 1336 2853274 SGTC_762 1165-0429 115 µM 0.616423717626986 0.287279685437761 no 988 0.268807451877526 1374 5967793 SGTC_897 1000-0139 31.4 µM 0.616045460937068 0.287402909608191 no 989 0.268932258056734 1315 6151020 SGTC_345 1362-0200 395 µM 0.61349791639748 0.288233470263081 no 990 0.269773580030112 1296 1419823 SGTC_628 1636-0253 16 µM 0.613385554601761 0.288270128958035 no 991 0.269810717635144 1300 4456143 SGTC_516 3992-2719 87.3 µM 0.611669094044099 0.288830407454608 no 992 0.270378356924397 1251 5350887 YDR037W KRS1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.609464647737795 0.289550722799799 no 993 0.271108249258677 1389 94937 An inhibitor of serotonin biosynthesis. SGTC_2491 paeonol 100 µM 0.609286333888604 0.289609024717569 no 994 0.271167331914931 1269 11092 Increases levels of cortical cytochrome oxidase. SGTC_1633 st005664 67.9 µM 0.606626033464835 0.290479496566539 no 995 0.272049559677552 1327 2063822 SGTC_2756 carbadox 75.1 µM 0.606363365095472 0.29056551016771 no 996 0.272136744986239 1321 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2213 7173844 200 µM 0.605299107579506 0.290914134718357 no 997 0.272490137141015 1309 892728 SGTC_381 3461-2219 42.7 µM 0.603657936139992 0.29145212488699 no 998 0.273035542781401 1340 2883159 SGTC_3074 9116018 49.47 µM 0.6013903772606 0.292196212927695 no 999 0.273790003186828 1380 17027303 SGTC_247 mechlorethamine 29.705 µM 0.598756331864402 0.293061669681451 no 1000 0.274667693122853 1279 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_994 3910-0338 138 µM 0.59545222175817 0.29414896478703 no 1001 0.275770613550191 1434 3479481 SGTC_698 k064-0052 127 µM 0.58670813240772 0.297035368753037 no 1002 0.278699872507596 1416 5088751 SGTC_563 tetrahydrosecaminediol 614 µM 0.583527372808454 0.298088534010896 no 1003 0.279769167807541 1417 334274 A psychoactive constituent of the cannabis plant. SGTC_1923 st058458 19.1 µM 0.583108249930208 0.298227434440912 no 1004 0.279910215174504 1472 3534982 SGTC_1846 st056244 14.8 µM 0.582500673467252 0.298428842102938 no 1005 0.280114744009627 1393 5393182 SGTC_1944 st076371 56.9 µM 0.580171219381296 0.299201614004033 no 1006 0.280899580023975 1346 24208455 SGTC_1403 3909-7815 62.9 µM 0.579696648916134 0.299359159041601 no 1007 0.28105960179704 1374 6615483 SGTC_2081 5214970 32.255 µM 0.578474155706422 0.299765168135595 no 1008 0.281472020515717 1375 2063512 SGTC_1077 5-fluorocytosine 377 nM 0.577803146891254 0.29998812659487 no 1009 0.281698515223281 1370 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_124 0136-0217 7.121 µM 0.575505068490769 0.300752285108717 no 1010 0.282474881887964 1486 3976905 SGTC_2616 abietic acid 100 µM 0.575196992849565 0.300854793350945 no 1011 0.282579038161456 1385 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1698 5-fluorocytosine 1.055 µM 0.57478493699035 0.300991924314765 no 1012 0.28271837761641 1401 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1558 st069300 45.6 µM 0.572401110197486 0.301785807215494 no 1013 0.283525131948811 1380 24208000 SGTC_1941 st076221 61.8 µM 0.570821553750257 0.302312362848613 no 1014 0.284060305450418 1366 2828568 SGTC_2300 7976697 71.57 µM 0.570696751568652 0.302353984048943 no 1015 0.284102610582215 1320 2236109 SGTC_952 1185-0122 232 µM 0.570602568639464 0.302385395510563 no 1016 0.284134538471357 1315 678600 SGTC_205 1486-1330 71.903 µM 0.568975537930581 0.302928266249618 no 1017 0.284686370437773 1401 4118834 SGTC_2367 9070478 135.38 µM 0.568475733912236 0.303095117073498 no 1018 0.28485598915759 1403 572802 SGTC_1103 duloxetine 36.1 µM 0.56624111299109 0.303841608390715 no 1019 0.285614942587095 1491 60835 A selective serotonin reuptake inhibitor. SGTC_1415 3966-0071 78.1 µM 0.564744033129187 0.304342177070872 no 1020 0.286123939631133 1381 2893185 SGTC_2571 chrysanthemic acid 100 µM 0.564560073602742 0.304403711722902 no 1021 0.286186514344932 1334 2743 An insecticide. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.563413430527319 0.304787389795149 no 1022 0.286576696927076 1439 688751 SGTC_636 0kpi-0074 126 µM 0.563314033792112 0.304820659044409 no 1023 0.286610531778798 1376 616434 SGTC_960 1222-0186 7.7 µM 0.562850829587673 0.304975720188111 no 1024 0.286768232418657 1446 3126296 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.562702352432677 0.305025431463579 no 1025 0.286818791057531 1454 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_760 0568-0725 82.9 µM 0.559746690325573 0.306015757275071 no 1026 0.287826115173448 1424 3916171 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.55925759176915 0.306179772000879 no 1027 0.287992966666408 1445 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1192 1488-0095 21.4 µM 0.555739451511421 0.307360691522733 no 1028 0.28919449135565 1403 915875 SGTC_255 tunicamycin 200.472 nM 0.555258692122845 0.30752222161955 no 1029 0.289358864442518 1408 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3055 9094636 49.47 µM 0.549438001121572 0.309480867234723 no 1030 0.291352450630142 1456 25236176 SGTC_1906 st060206 94.7 µM 0.549002352159749 0.309627680698631 no 1031 0.291501917811446 1400 5133468 SGTC_483 fpl-64176 144 µM 0.54837627177328 0.309838722648379 no 1032 0.291716782881633 1428 3423 SGTC_2618 avocadyne 43.43 µM 0.548246618750886 0.309882434500632 no 1033 0.291761287838332 1400 3015189 SGTC_1896 st058441 89 µM 0.547926264015022 0.309990451983394 no 1034 0.29187126701244 1348 688759 SGTC_1596 piperlongumine 63 µM 0.547327044472131 0.310192541368019 no 1035 0.292077033511615 1506 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2997 9067075 71.4286 µM 0.546279385896641 0.310546006487738 no 1036 0.292436951998943 1456 27209819 SGTC_332 4112-0506 40.9 µM 0.545549140029964 0.310792484588678 no 1037 0.292687946628081 1443 2790355 SGTC_3292 9120825 59.784 µM 0.545538725329564 0.310796000451543 no 1038 0.292691527014324 1472 24824900 SGTC_2583 asiatic acid 100 µM 0.541439263784872 0.312181262608561 no 1039 0.294102425131735 1418 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1643 st009866 20.2 µM 0.539676984642206 0.312777578613871 no 1040 0.294709907438478 1431 3156273 YOR207C RET1 SGTC_2227 7312221 64.1025 µM 0.539444571243815 0.312856258758534 no 1041 0.294790066764088 1441 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2560 caryophyllene 100 µM 0.539048309978934 0.312990426852655 no 1042 0.294926760354386 1433 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_831 k061-1017 217 µM 0.536491150158715 0.313856837688436 no 1043 0.295809575303683 1509 1240153 SGTC_2769 toremifene 3.73 µM 0.535927557802243 0.314047931050036 no 1044 0.296004308897647 1451 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_769 0302-0231 76 µM 0.534237648976877 0.314621215541324 no 1045 0.296588562151462 1439 571869 YER009W NTF2 SGTC_2123 5259487 200 µM 0.533865635911309 0.314747477319094 no 1046 0.296717249378084 1473 2173474 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.53361835361184 0.314831417278337 no 1047 0.296802803724389 1460 66535 A nucleotide analog. SGTC_1088 bifonazole 369 nM 0.533506756722105 0.314869301968105 no 1048 0.296841417540628 1379 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_580 1123-0028 41 µM 0.532818862764102 0.315102869842871 no 1049 0.29707948756658 1460 1677248 YPR107C YTH1 SGTC_2373 9071805 200 µM 0.531329220849425 0.315608916988913 no 1050 0.297595329842464 1521 10149009 SGTC_2895 9054447 58.44 µM 0.530838303217993 0.315775762747996 no 1051 0.297765417312679 1451 2697450 SGTC_3209 9113616 49.47 µM 0.530075981399006 0.316034923725173 no 1052 0.298029625626801 1532 16649353 SGTC_3168 9103419 49.47 µM 0.530012265440651 0.316056588870511 no 1053 0.298051713376335 1417 16649256 SGTC_2333 9017922 200 µM 0.529419494632953 0.316258177209846 no 1054 0.298257238817482 1576 3163164 SGTC_2207 7258803 200 µM 0.526142948065949 0.317373442867926 no 1055 0.299394445102003 1461 3666799 SGTC_1753 st043925 64 µM 0.524235242466961 0.318023550033581 no 1056 0.300057465732087 1481 670181 SGTC_1657 st012939 43.4 µM 0.521514566029951 0.318951671610791 no 1057 0.301004180619312 1494 24207257 SGTC_2730 imipramine 71.33 µM 0.520076007108495 0.319442876008745 no 1058 0.301505300162208 1481 3696 A tricyclic antidepressant. SGTC_1325 1431-0015 227 µM 0.518743163748554 0.319898266176536 no 1059 0.301969928614042 1369 1103340 SGTC_2682 pyrogallin 40.03 µM 0.518716034631159 0.319907538154924 no 1060 0.301979389148347 1475 822798 An ATP competetive kinase inhibitor. SGTC_95 0471-0001 561.058 µM 0.518223997926772 0.320075722147027 no 1061 0.302150996528953 1348 4015405 SGTC_1141 3253-0389 52.6 µM 0.518168474188047 0.320094703143236 no 1062 0.302170364262288 1445 5402031 SGTC_328 k915-0120 63.5 µM 0.517626433752616 0.32028002640817 no 1063 0.302359467514559 1528 6624543 SGTC_1234 0326-0494 15.5 µM 0.516064387368637 0.320814339676019 no 1064 0.302904719926316 1534 1547813 SGTC_738 1315-0003 72.4 µM 0.515571927964731 0.320982867290432 no 1065 0.303076710436525 1523 6251474 SGTC_3050 9093513 49.47 µM 0.514992534682762 0.321181192318878 no 1066 0.303279118354692 1430 25236664 SGTC_2826 7992541 19.48 µM 0.514867044327027 0.321224154110392 no 1067 0.303322965693618 1512 2985066 SGTC_518 1021-0119 62.6 µM 0.514781565431543 0.32125341929479 no 1068 0.303352834328916 1417 1097762 SGTC_734 2023-0417 80 µM 0.512651654162408 0.321982989411399 no 1069 0.304097506848133 1488 3935732 SGTC_2654 protoveratrine a 100 µM 0.50397321024355 0.324962738771223 no 1070 0.307140101379554 1469 5702278 A heart drug and vasodilator. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.502622386610365 0.325427559954341 no 1071 0.307614893400318 1492 756377 SGTC_3211 9128781 49.47 µM 0.502105137523309 0.325605618396229 no 1072 0.307796783259648 1472 17194361 SGTC_260 nsc-65238 3.989 µM 0.501952410129054 0.325658201069139 no 1073 0.307850498653079 1524 3246252 SGTC_979 1426-2828 121 µM 0.49873962396973 0.32676513724522 no 1074 0.308981413154912 1560 747872 SGTC_2696 st077691 74.316 µM 0.498728477266095 0.326768980403035 no 1075 0.308985340004435 1490 757133 SGTC_412 gemfibrozil 100 µM 0.498424550852257 0.326873775160514 no 1076 0.309092418032834 1471 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2969 9091408 28.7 µM 0.496259574765154 0.327620660243491 no 1077 0.309855641868789 1418 4286311 SGTC_1669 st015249 58.4 µM 0.495373579896744 0.327926514743023 no 1078 0.310168220345047 1546 722793 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.494169717653944 0.328342285292921 no 1079 0.310593162108353 1466 688664 SGTC_2763 lisinopril 49.32 µM 0.492579654883497 0.32889176150098 no 1080 0.311154813225579 1468 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2247 cerulenin 830 nM 0.491487506564882 0.329269388413028 no 1081 0.311540843144584 1549 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3023 9089636 49.47 µM 0.491129513047816 0.32939320805954 no 1082 0.311667424384438 1557 17249241 SGTC_793 0488-0545 106 µM 0.490440549119606 0.329631553483766 no 1083 0.311911094516835 1458 292548 SGTC_2469 5655019 90.81 µM 0.489789894455539 0.329856709462664 no 1084 0.312141291184325 1616 2788239 SGTC_175 3793-3120 23.7 µM 0.488247108181593 0.330390829702923 no 1085 0.312687410333281 1482 5322297 SGTC_1006 4099-6547 255 µM 0.4878042315184 0.330544219708299 no 1086 0.312844256932393 1529 3146833 SGTC_181 1447-1644 8.07 µM 0.486078415445365 0.331142226257671 no 1087 0.313455784936156 1521 534600 SGTC_2208 7283366 200 µM 0.485721763070512 0.331265862418739 no 1088 0.313582225656171 1573 898663 SGTC_256 clotrimazole 625 nM 0.484859131856162 0.331564975885525 no 1089 0.313888136990787 1506 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3246 9135460 32.98 µM 0.484838099961415 0.33157226994225 no 1090 0.313895597043346 1520 41446951 SGTC_755 1995-0008 37.3 µM 0.484437701294546 0.331711144103654 no 1091 0.31403763370888 1511 689533 SGTC_1064 honokiol 6.76 µM 0.484185076900548 0.331798776180219 no 1092 0.314127263385808 1492 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3274 9138298 49.47 µM 0.482570503628042 0.332359067612785 no 1093 0.314700363438034 1477 17015756 SGTC_1674 st016616 23.6 µM 0.481943780264541 0.332576655074811 no 1094 0.314922942131037 1450 625830 SGTC_818 4072-2707 53.5 µM 0.4815149979909 0.332725553339347 no 1095 0.315075261454302 1443 882871 SGTC_1512 0259-0544 12.2 µM 0.481429397848055 0.332755281872291 no 1096 0.31510567355808 1579 18476 SGTC_3321 9137793 26.8275 µM 0.480150162106964 0.3331996797105 no 1097 0.31556031092683 1499 4904192 SGTC_1661 st013063 9.66 µM 0.479811134251336 0.333317494992681 no 1098 0.315680847476752 1533 721395 SGTC_1266 0828-0227 32.9 µM 0.478907922992649 0.333631449419338 no 1099 0.316002067121235 1553 3913820 SGTC_158 k038-0087 26.446 µM 0.478712079130834 0.333699539735433 no 1100 0.316071735718536 1548 X158 SGTC_1046 2001-0062 216 µM 0.478096223890238 0.333913693839743 no 1101 0.316290859794304 1491 739778 SGTC_1356 1502-0781 85.8 µM 0.473047116101582 0.335671477364588 no 1102 0.318089782502567 1514 567702 SGTC_3265 9137266 49.47 µM 0.472588856782788 0.335831193453576 no 1103 0.318253267014559 1627 17224265 SGTC_2757 clomiphene 4.22 µM 0.472312285419032 0.335927600600174 no 1104 0.318351951286116 1662 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2770 toltrazuril 17.5 µM 0.471214606365492 0.336310335574177 no 1105 0.318743744557475 1545 68591 Kills coccidiodes. SGTC_2591 skatole 100 µM 0.469886221914146 0.33677373905907 no 1106 0.319218154282954 1528 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1368 1852-0141 284 µM 0.46950970108104 0.336905132504965 no 1107 0.319352676148373 1505 2838987 SGTC_2161 5662504 8.5105 µM 0.468663074342438 0.337200650203905 no 1108 0.319655242420544 1509 2859334 SGTC_2166 5933061 31.504 µM 0.468636913983008 0.337209783160061 no 1109 0.319664593486329 1683 2877375 SGTC_1143 3454-2408 5.08 µM 0.466711935265353 0.337882083743939 no 1110 0.32035299471788 1504 X1143 SGTC_1059 3448-6867 171 µM 0.461537650246624 0.339691767689815 no 1111 0.322206457843397 1570 3934407 SGTC_2091 4-phenylthiadiazole 200 µM 0.46039729900553 0.340091099890155 no 1112 0.322615536526985 1551 270010 SGTC_3006 9075424 71.4286 µM 0.459913855971424 0.340260447859739 no 1113 0.322789027118352 1497 7465181 SGTC_3237 9133362 49.47 µM 0.455289350894619 0.341882015770434 no 1114 0.324450543225967 1596 43845137 SGTC_1787 fluconazole 80 µM 0.451565100079134 0.343190037977517 no 1115 0.325791158397075 1488 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1063 disulfiram 1.84 µM 0.44914346088479 0.344041570420747 no 1116 0.32666408521662 1553 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2453 5731132 22.18 µM 0.448852977707043 0.344143767645719 no 1117 0.326768859403192 1675 1362040 SGTC_2185 6113692 200 µM 0.448579794324417 0.344239888878097 no 1118 0.326867406203727 1563 874150 SGTC_188 3229-0966 278.469 µM 0.447827794900946 0.344504536403342 no 1119 0.327138741058476 1678 5722370 SGTC_3284 9108171 64.8615 µM 0.447416981276387 0.344649144224014 no 1120 0.327287008577555 1571 8687505 SGTC_874 0599-0792 117 µM 0.446299718145266 0.345042539504347 no 1121 0.327690379916243 1695 765305 SGTC_2368 9071271 200 µM 0.446027779826192 0.345138316041842 no 1122 0.32778858968527 1519 27209959 SGTC_2818 7996756 12.99 µM 0.44557561588094 0.345297589912055 no 1123 0.32795191380775 1525 2241621 SGTC_1697 st025554 27.742 µM 0.44296044779222 0.346219314567343 no 1124 0.328897171753888 1545 1269519 SGTC_2122 5258151 111.688 µM 0.442661321649594 0.346324800769 no 1125 0.329005361445483 1531 2173356 SGTC_3031 9088762 49.47 µM 0.441647887925163 0.346682274602685 no 1126 0.329372012524002 1495 205253 SGTC_3337 9144342 33.5465 µM 0.441434509469638 0.346757558125797 no 1127 0.329449231831725 1629 17682949 SGTC_143 4032-1194 15.74 µM 0.441417181930343 0.34676367184001 no 1128 0.329455502796288 1570 1806963 SGTC_275 trichlorophene 5.69 µM 0.44090254770246 0.346945269564452 no 1129 0.32964177458857 1598 62616 SGTC_466 geldanamycin 89.2 µM 0.440169616356391 0.3472039579481 no 1130 0.329907131953628 1601 5288382 HSP90 inhibitor. SGTC_1738 st035555 74 µM 0.439041265443946 0.347602348973545 no 1131 0.330315818073539 1577 5331140 SGTC_883 0850-0245 24.6 µM 0.43782254250039 0.348032837124117 no 1132 0.330757464212788 1644 6823229 YPR165W RHO1 SGTC_1280 0880-0253 10.1 µM 0.437705919932535 0.348074041863956 no 1133 0.330799738773766 1547 6836607 SGTC_1965 Pectolinarigenin 58.4 µM 0.436502747311382 0.348499247882846 no 1134 0.331236003189083 1548 5320438 An anti-inflammatory. SGTC_3182 9108849 49.47 µM 0.436289796781089 0.348574525302658 no 1135 0.331313241879194 1566 17133045 SGTC_155 k072-0202 43.6 µM 0.435904706804998 0.348710668677864 no 1136 0.331452935006141 1548 5857737 SGTC_3100 9120536 49.47 µM 0.43556176780271 0.348831926546983 no 1137 0.331577357418936 1575 16421196 SGTC_597 k018-0003 82.8 µM 0.433399645365263 0.349596774361585 no 1138 0.332362229063849 1666 6786234 SGTC_3227 9130768 49.47 µM 0.432011597237269 0.350088116685245 no 1139 0.332866492155445 1604 17720899 SGTC_23 0213-0011 39.996 µM 0.431799257561538 0.35016330300601 no 1140 0.332943659591294 1666 627608 SGTC_3063 1327-0034 4 µM 0.431570103849206 0.35024444951645 no 1141 0.333026945439438 1561 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2598 perillyl alcohol 100 µM 0.43036598053305 0.350670958574581 no 1142 0.333464718974571 1627 10819 An apoptosis inducer. SGTC_1248 0469-0687 58.6 µM 0.42997392668415 0.350809867500346 no 1143 0.333607303868199 1658 4017482 SGTC_966 1300-0360 30.2 µM 0.428558555052254 0.351311514859158 no 1144 0.334122256056914 1587 70588 SGTC_1344 1488-0097 29.1 µM 0.428427937252971 0.351357822540702 no 1145 0.334169794263234 1594 747966 SGTC_595 3909-8003 73.7 µM 0.427864809020996 0.351557492584307 no 1146 0.334374774622337 1614 699517 SGTC_2621 lithochol-11-enic acid 100 µM 0.427790950793951 0.351583683754214 no 1147 0.334401662902878 1720 6708711 SGTC_1239 0337-0584 35.4 µM 0.427694156681977 0.351618009379395 no 1148 0.334436902338514 1728 914301 YML130C ERO1 SGTC_3178 9107506 49.47 µM 0.427218528987611 0.351786696489399 no 1149 0.334610083355785 1608 8897194 SGTC_2664 lyso-paf C-16 73.48 µM 0.42707811613427 0.351836501185383 no 1150 0.334661215873882 1587 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1326 1431-2094 10.8 µM 0.427037978763266 0.351850738451626 no 1151 0.33467583279772 1544 616278 SGTC_892 0929-0076 29 µM 0.423946101545511 0.352948091952092 no 1152 0.335802560758893 1586 5751038 SGTC_139 0099-0334 718.624 µM 0.422575310805817 0.353434998381372 no 1153 0.336302571522001 1637 97690 SGTC_1947 st076332 61.6 µM 0.420168676778825 0.354290417581974 no 1154 0.337181117699852 1615 24208416 SGTC_1435 4092-0789 56.7 µM 0.419981720546753 0.354356900558871 no 1155 0.337249403675826 1686 2248285 SGTC_1018 4259-0013 28.1 µM 0.419042280942832 0.354691039169047 no 1156 0.337592616182585 1618 6801262 SGTC_1662 st014054 52 µM 0.418668340812688 0.354824072821104 no 1157 0.337729268146077 1574 2838777 SGTC_869 0564-0080 44.1 µM 0.418329738312863 0.35494454996547 no 1158 0.337853024852376 1552 6843321 SGTC_477 mead ethanolamide 10 µM 0.417365111019515 0.355287850613701 no 1159 0.338205685057585 1564 16061185 SGTC_2182 6325192 200 µM 0.417299147224355 0.355311330724821 no 1160 0.338229806096579 1594 736248 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.416059590285528 0.355752658673196 no 1161 0.338683199347768 1754 551469 SGTC_1146 3579-1023 7 µM 0.415257549056943 0.356038318005857 no 1162 0.33897668696111 1701 X1146 SGTC_1865 st057639 52.2 µM 0.414844600568746 0.356185427501168 no 1163 0.339127833620974 1592 688818 SGTC_1644 st010134 20.9 µM 0.414729863830185 0.356226305319999 no 1164 0.339169833952701 1655 3818134 SGTC_1106 tegaserod maleate 11.7 µM 0.41380473295341 0.356555966556706 no 1165 0.339508558745121 1648 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_535 2293-4129 48.2 µM 0.413763360092861 0.356570711872205 no 1166 0.339523709918379 1710 396118 YIL048W NEO1 SGTC_2866 9034245 58.44 µM 0.410366572464511 0.357782058765842 no 1167 0.340768531820607 1717 6462273 SGTC_1833 st055984 71 µM 0.409374467997071 0.358136129601361 no 1168 0.341132436849025 1621 676288 SGTC_3128 9127691 49.47 µM 0.408900672161265 0.358305265041964 no 1169 0.341306277866026 1630 41316314 SGTC_15 0266-0086 27.098 µM 0.40639102278629 0.359201621636366 no 1170 0.34222765737258 1675 1712902 YIL048W NEO1 SGTC_359 0081-0058 15.9 µM 0.405800528822404 0.359412637757752 no 1171 0.342444585042285 1763 3494159 SGTC_3056 9094900 49.47 µM 0.404707756787921 0.359803258657429 no 1172 0.342846169900039 1530 25236784 SGTC_993 3909-8757 62.7 µM 0.404580634160209 0.359848709269297 no 1173 0.34289289797668 1627 4288324 YLR208W SEC13 SGTC_2886 9058944 51.95 µM 0.403931691308805 0.360080759018921 no 1174 0.343131475567546 1588 4949929 SGTC_3079 9117512 49.47 µM 0.401955213148309 0.360787827800374 no 1175 0.343858493723263 1683 7185044 SGTC_2140 5586273 200 µM 0.400794443088603 0.361203305813117 no 1176 0.344285735233807 1620 854421 SGTC_400 oxethazaine 37.5 µM 0.400478688861334 0.361316353054817 no 1177 0.344401988458512 1609 4621 A local anesthetic. SGTC_2858 9025781 8.96 µM 0.400272531260262 0.361390168730893 no 1178 0.344477898735793 1670 4894980 YPL153C RAD53 SGTC_1436 4092-1007 8.32 µM 0.399512637726757 0.36166229664596 no 1179 0.344757756850903 1620 2881121 SGTC_469 w7 172 µM 0.399352138488212 0.361719782499823 no 1180 0.344816877339899 1670 45115570 A P450 inhibitor. SGTC_1274 0865-0114 173 µM 0.399141705248012 0.36179515789382 no 1181 0.344894396944508 1645 870624 SGTC_1015 4130-4525 82 µM 0.399077019501388 0.361818328854802 no 1182 0.344918227252196 1575 1363237 SGTC_1729 st035615 45.989 µM 0.398986727156238 0.361850673154883 no 1183 0.344951492090557 1611 17385451 SGTC_1680 diphenhydramine 100 µM 0.397502757115987 0.362382398458308 no 1184 0.345498376896209 1616 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_909 3448-9333 149 µM 0.3972603263305 0.362469289752556 no 1185 0.345587750168413 1566 3344074 SGTC_1684 st024538 14.6195 µM 0.396616475577435 0.36270009113699 no 1186 0.345825150612907 1607 6732859 SGTC_557 1315-0110 16.2 µM 0.396522742109819 0.362733695965569 no 1187 0.34585971704509 1569 6833801 SGTC_1816 st051957 91.6 µM 0.396102742462908 0.362884285003562 no 1188 0.346014617616504 1641 674121 SGTC_1887 st057648 70.8 µM 0.395601004385523 0.363064208795225 no 1189 0.346199698017461 1747 688672 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.394336439124803 0.363517817217055 no 1190 0.34666633188455 1707 140250 A respiratory chain inhibitor. SGTC_3331 9141060 1.957 µM 0.393839021671463 0.36369629683497 no 1191 0.346849946395063 1585 4906567 YPR165W RHO1 SGTC_1693 xanthone 101.9 µM 0.393767974694849 0.363721791796149 no 1192 0.346876175303285 1671 7020 An insecticide. SGTC_35 0133-0054 64.071 µM 0.392986148164363 0.364002387368995 no 1193 0.347164856102569 1544 99677 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.392846366364307 0.364052562394633 no 1194 0.347216478338535 1680 6708739 YPR165W RHO1 SGTC_1483 3453-0561 55.9 µM 0.391935465688076 0.364379589507394 no 1195 0.347552948673026 1680 4546991 SGTC_603 3794-0023 45.9 µM 0.390203704275713 0.365001590190879 no 1196 0.348192961346048 1741 3802260 SGTC_1805 st050013 60.3 µM 0.38841765725062 0.365643461063441 no 1197 0.348853489693938 1682 4037144 SGTC_654 1124-0271 80.9 µM 0.38784725995038 0.365848530239266 no 1198 0.349064534653351 1591 5403748 SGTC_2023 5144124 124 µM 0.386278847443985 0.366412603212663 no 1199 0.349645082209346 1621 2830192 SGTC_2681 menadione 3.18 µM 0.386254150298989 0.366421487749279 no 1200 0.349654226669173 1654 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1968 st069590 43.6 µM 0.384946265414111 0.366892087672988 no 1201 0.350138613665112 1727 6384066 SGTC_2811 7967822 32.47 µM 0.384623579943519 0.367008226369203 no 1202 0.350258160691268 1727 2232244 SGTC_3289 9119912 71.43 µM 0.384010268645758 0.367228998624283 no 1203 0.350485418328122 1663 17014829 SGTC_3199 9111318 49.47 µM 0.383477652175986 0.367420758969862 no 1204 0.350682818567447 1718 8548020 SGTC_1509 1326-1131 80 µM 0.38302857623576 0.367582467532079 no 1205 0.350849288047594 1759 768313 SGTC_304 1310-0298 97 µM 0.382246843684577 0.36786401900984 no 1206 0.351139139428623 1649 1550234 SGTC_3350 9150499 3.57 µM 0.381901274064081 0.367988503193011 no 1207 0.351267297610738 1629 4910996 YPR165W RHO1 SGTC_594 1487-1584 10.8 µM 0.381149041493553 0.368259527069382 no 1208 0.351546329554516 1599 5013332 SGTC_860 0443-0016 25.1 µM 0.381135867178618 0.368264274263043 no 1209 0.351551217127106 1669 5337942 SGTC_530 4358-1714 28 µM 0.380986972420442 0.368317927957647 no 1210 0.351606457677854 1722 1564641 SGTC_1616 st002734 56.1 µM 0.380183189652952 0.368607612535763 no 1211 0.351904718392327 1681 4026101 SGTC_1903 st060211 78.3 µM 0.378529986036888 0.369203664345974 no 1212 0.352518461180668 1773 688960 SGTC_1751 st044839 27.194 µM 0.378467707115129 0.369226124764037 no 1213 0.352541589407497 1687 5291326 SGTC_2463 5473429 200 µM 0.376951643286077 0.369773019161629 no 1214 0.3531047707937 1648 5399405 SGTC_2994 9053520 71.4286 µM 0.375947165513576 0.370135512747918 no 1215 0.353478087601479 1769 4647384 SGTC_49 0717-0965 32.132 µM 0.375918411244547 0.370145891221464 no 1216 0.353488776278729 1732 5889349 YGL099W LSG1 SGTC_2641 levomentholum 100 µM 0.375155661000212 0.370421230343277 no 1217 0.35377235168104 1698 16666 SGTC_109 0132-0036 33.701 µM 0.373331964990599 0.371079820733841 no 1218 0.354450694387637 1674 67274 A color developer. SGTC_2111 5486399 200 µM 0.370962286324562 0.371936145682286 no 1219 0.355332810915152 1641 689674 SGTC_1762 st045503 25.4615 µM 0.370205686247539 0.372209690097129 no 1220 0.355614620049934 1661 4645554 SGTC_2089 5281248 129.67 µM 0.370057993689073 0.37226309502202 no 1221 0.355669639979868 1635 2737878 SGTC_954 1189-0853 2.85 µM 0.36662457851347 0.373505292001728 no 1222 0.356949535992589 1671 2828194 SGTC_438 sphingosine 6.67 µM 0.366166671184833 0.373671060890729 no 1223 0.357120355144672 1511 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2732 terfenadine 20 µM 0.365044144592252 0.374077530121993 no 1224 0.357539227014827 1702 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_365 0121-0052 13.6 µM 0.364761665918088 0.374179838314169 no 1225 0.357644661256492 1720 3101739 SGTC_1651 st011928 86.1 µM 0.36474468103111 0.374185990187018 no 1226 0.357651001156365 1692 720198 SGTC_277 nystatin 15.5 µM 0.363346784994146 0.374692413443415 no 1227 0.358172924279204 1638 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2473 5854593 8.94 µM 0.362711376212554 0.374922677895029 no 1228 0.358410250330094 1664 2872951 SGTC_2928 9011484 9.79 µM 0.361720455708059 0.37528186446387 no 1229 0.358780469640183 1680 2994751 SGTC_949 1165-0505 146 µM 0.359197786391719 0.376196763315498 no 1230 0.359723566243117 1653 6244267 SGTC_1656 st012921 11 µM 0.358795308077836 0.376342795029758 no 1231 0.359874111450039 1759 6732821 SGTC_2900 5328528 85.29 µM 0.358375317517257 0.376495199609396 no 1232 0.36003123021488 1631 795359 SGTC_3160 9100216 49.47 µM 0.356659194989997 0.377118139478585 no 1233 0.360673478358684 1710 17191039 SGTC_3348 9149464 3.537 µM 0.356306361454117 0.377246255165319 no 1234 0.360805572895289 1668 1951442 SGTC_493 zm226600 134 µM 0.355030638073237 0.377709589597087 no 1235 0.36128331928248 1721 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1471 k673-0312 37 µM 0.354990477834711 0.377724178395581 no 1236 0.361298362430905 1732 24099884 SGTC_640 3381-0960 37.1 µM 0.35382127355404 0.378148985461103 no 1237 0.361736414748169 1771 1745025 SGTC_174 3553-0389 74.3 µM 0.3535927570268 0.378232029615662 no 1238 0.361822051597689 1742 738071 SGTC_1244 0416-0015 52.5 µM 0.352967630082197 0.378459232895958 no 1239 0.362056354034405 1698 96201 SGTC_199 4063-0024 41.6 µM 0.350558126456209 0.379335362938659 no 1240 0.362959937724496 1788 306215 SGTC_3266 9136860 49.47 µM 0.350277434085447 0.379437467116337 no 1241 0.363065249417455 1682 4871271 YPR165W RHO1 SGTC_948 3448-0295 75.3 µM 0.35010612146154 0.379499787636745 no 1242 0.36312952850993 1662 678569 SGTC_404 fumagillin 50 µM 0.348674936268293 0.380020549834033 no 1243 0.363666681368852 1725 12015870 A methionine aminopeptidase binder. SGTC_531 3788-1495 174 µM 0.347504708164639 0.380446519914298 no 1244 0.364106091019812 1680 2896655 SGTC_2904 7225135 42.03 µM 0.34642256482188 0.38084055567589 no 1245 0.364512584736363 1771 4446116 SGTC_1546 5-methoxyflavanone 78.7 µM 0.345888806301487 0.381034956203829 no 1246 0.36471314065518 1823 147795 SGTC_2366 9070441 60.58 µM 0.345883614230962 0.381036847358669 no 1247 0.364715091720213 1635 6837235 SGTC_2467 5474540 200 µM 0.344394396114727 0.381579395875876 no 1248 0.365274851331468 1679 5413519 SGTC_1779 st039427 55 µM 0.343889605667013 0.381763352841924 no 1249 0.365464654577267 1900 1124498 SGTC_450 aminopyrene 156 nM 0.343738446395934 0.381818443869648 no 1250 0.365521497486229 1786 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1513 0337-0559 19 µM 0.341644367971362 0.382581890845982 no 1251 0.366309271644837 1630 775073 SGTC_1114 scopoletin 1.73284 µM 0.341154859340528 0.382760419009259 no 1252 0.366493501962931 1823 5280460 A coumarin with genotoxic properties. SGTC_3344 9148862 3.898 µM 0.341003341481961 0.382815683974538 no 1253 0.366550533105867 1812 4905352 SGTC_1534 6-azauridine 81.6 µM 0.340942057800948 0.382838037400225 no 1254 0.36657360104802 1725 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2177 5811945 192 µM 0.338335938013511 0.383788988495801 no 1255 0.367555022139499 1800 5343475 SGTC_3134 9127454 49.47 µM 0.337579861806659 0.38406500562022 no 1256 0.367839910061975 1743 24262820 SGTC_1370 2001-0092 44.6 µM 0.337573025852898 0.384067501457648 no 1257 0.367842486166903 1853 790957 SGTC_790 1575-0012 79.1 µM 0.336653475361629 0.384403277255008 no 1258 0.368189069648552 1835 378741 YLR208W SEC13 SGTC_1313 1220-0047 237 µM 0.336418499656066 0.384489093055401 no 1259 0.368277650468721 1774 3528706 SGTC_2347 9049783 174.81 µM 0.335764154886212 0.384728097028699 no 1260 0.368524361353583 1781 6467988 YPL169C MEX67 SGTC_2243 6634756 200 µM 0.330469976705977 0.386663436312627 no 1261 0.370522437316602 1845 885676 SGTC_2937 9044753 11.33 µM 0.329307608990619 0.387088730851828 no 1262 0.370961596717229 1694 6465530 YGL099W LSG1 SGTC_555 4296-0685 37 µM 0.329214809114727 0.387122690915526 no 1263 0.370996665112211 1770 2908540 YHR072W ERG7 SGTC_2051 5263410 176 µM 0.32920999051267 0.387124454303905 no 1264 0.37099848605598 1798 227584 SGTC_1177 0983-0204 23.6 µM 0.327894314446806 0.387606018717402 no 1265 0.371495786358991 1885 766818 SGTC_1617 st002906 78 µM 0.325875470520574 0.38834529307791 no 1266 0.372259287608695 1719 5150859 SGTC_2801 7907800 81.82 µM 0.325805293591786 0.388370998249133 no 1267 0.372285836688725 1711 6620925 SGTC_2995 9067767 71.4286 µM 0.325590197557719 0.388449789017092 no 1268 0.37236721481784 1752 11673567 SGTC_2222 6885208 172.143 µM 0.323958221785506 0.389047739334343 no 1269 0.37298483205847 1773 609514 SGTC_3076 9116187 49.47 µM 0.323249742866823 0.38930740549587 no 1270 0.373253055932649 1876 27241210 SGTC_1612 st002233 45.4 µM 0.319345782974939 0.390739138213107 no 1271 0.374732159440032 1753 1035021 SGTC_2688 kanamycin b 96.69 µM 0.319255356372779 0.39077231877814 no 1272 0.374766441546317 1732 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_913 3487-1245 167 µM 0.318786885390113 0.390944229282843 no 1273 0.374944061892152 1655 4016153 SGTC_1409 3909-8004 61.9 µM 0.318658448563594 0.390991364292423 no 1274 0.374992763232779 1768 2119279 SGTC_2406 ethylparaben 405.7 µM 0.317443562092237 0.391437294397429 no 1275 0.375453528671005 1517 8434 A possible steroid mimic. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.315966491154739 0.391979652804835 no 1276 0.376013971175076 1821 688761 SGTC_1307 1187-1599 12.2 µM 0.315201432039628 0.392260653702751 no 1277 0.376304359166986 1739 1538471 SGTC_10 0279-0212 42.575 µM 0.315000348260526 0.392334519709059 no 1278 0.376380694721467 1716 39851 YBR002C RER2 SGTC_1056 3448-1962 115 µM 0.314797872151977 0.392408901092628 no 1279 0.376457563718643 1782 715507 SGTC_3075 9116269 49.47 µM 0.314684822440697 0.392450432610904 no 1280 0.376500484582868 1772 17015205 YNL244C SUI1 SGTC_665 3914-0008 307 µM 0.313871650759247 0.392749206764507 no 1281 0.37680926126205 1707 1069549 SGTC_3120 9124077 49.47 µM 0.3113424978295 0.393678867096413 no 1282 0.377770131479287 1791 18774327 YGL155W CDC43 SGTC_148 3253-0744 288.01 µM 0.31033156656233 0.394050632854325 no 1283 0.378154414313827 1705 6893655 SGTC_1090 efavirenz 20.7 µM 0.307902156772019 0.394944432423698 no 1284 0.379078392302411 1820 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2564 betulinic acid 100 µM 0.30510316478423 0.395974889833877 no 1285 0.380143790451813 1981 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2084 5306078 60.6385 µM 0.305054986997435 0.395992633020702 no 1286 0.380162136659827 1837 679340 SGTC_1933 st074711 15.9 µM 0.304848155739032 0.396068808450061 no 1287 0.380240901524589 1758 17250958 SGTC_2037 5169046 200 µM 0.304458203559278 0.396212437644541 no 1288 0.380389415460254 1824 5718022 SGTC_2524 avocatin b 10.57 µM 0.304255448524044 0.396287122991408 no 1289 0.380466642021376 1874 6710748 SGTC_321 4534-3890 65.3 µM 0.303782623080417 0.396461304262162 no 1290 0.380646753133621 1888 699746 SGTC_1826 st055655 41.6 µM 0.301305391135334 0.397374213587456 no 1291 0.381590815151609 1781 676168 SGTC_1292 0kpi-0043 232 µM 0.299763989603075 0.39794253496303 no 1292 0.382178592486543 1765 3333905 SGTC_1361 1608-0041 5.61 µM 0.298189690984692 0.398523209247638 no 1293 0.382779194752075 1757 X1361 SGTC_3181 9108277 49.47 µM 0.29708717242686 0.398930003072302 no 1294 0.383199978711853 1753 17097298 SGTC_614 0462-0418 107 µM 0.296562416615989 0.399123659655308 no 1295 0.383400303904483 1804 5188303 SGTC_1973 st070275 50.2 µM 0.294821003989179 0.399766490561606 no 1296 0.384065310178377 1894 17118334 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.293305789801832 0.400326042996301 no 1297 0.384644214273161 1852 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1752 st044819 83.042 µM 0.29322998898998 0.400354040812015 no 1298 0.384673181568368 1749 441209 YML126C ERG13 SGTC_2966 9084041 48.03 µM 0.29309193460878 0.400405033944461 no 1299 0.384725940731478 1606 17741380 SGTC_1224 0823-0416 294 µM 0.292980901951322 0.400446047297445 no 1300 0.384768374762743 1857 3598164 SGTC_3356 9151811 4.48 µM 0.291862680231646 0.40085915826837 no 1301 0.385195809288014 1762 1859254 YPR165W RHO1 SGTC_3054 9094397 49.47 µM 0.290899687425104 0.40121501103513 no 1302 0.385564020189627 1744 2598354 SGTC_896 0964-0007 44.5 µM 0.28919478492813 0.401845221004275 no 1303 0.386216161229804 1915 6756758 SGTC_1969 st069479 40.1 µM 0.288743509641478 0.402012075799564 no 1304 0.386388832121048 1885 3895485 SGTC_1225 1216-0074 20.6 µM 0.287127574526686 0.402609698893963 no 1305 0.387007319642022 1775 4241466 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.28699391567449 0.402659140309792 no 1306 0.387058489477365 1821 88881 An O-methylated flavonoid and antioxidant. SGTC_3060 1327-0027 12.5 µM 0.286938078789285 0.402679795255141 no 1307 0.387079866601852 1913 16000455 YPR107C YTH1 SGTC_2484 5809818 12.04 µM 0.286105129550975 0.402987948548925 no 1308 0.387398801444639 1790 2870548 SGTC_1407 3909-7909 12.3 µM 0.284437880461608 0.403604935660524 no 1309 0.388037416426153 1793 4411780 SGTC_2477 5967686 25.23 µM 0.284069487294827 0.403741296744597 no 1310 0.388178564871301 1758 776118 SGTC_3152 9099253 49.47 µM 0.283652400074246 0.403895696101378 no 1311 0.388338388087312 1866 25236131 SGTC_1564 D-Arginine 115 µM 0.281899062121686 0.404544918717336 no 1312 0.389010454351777 1711 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2493 resveratrol 26.09 µM 0.281773872303238 0.404591283840257 no 1313 0.38905845318497 1769 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1606 st000094 49.2 µM 0.280475021839764 0.40507240319096 no 1314 0.389556543202152 1961 1242210 SGTC_708 3448-5400 146 µM 0.277396911994967 0.406213166452088 no 1315 0.390737676249937 1905 3462195 SGTC_3011 9081274 71.4286 µM 0.277267103513283 0.406261291712959 no 1316 0.390787508635804 1793 6625322 SGTC_2112 5488546 200 µM 0.276975983608891 0.406369226799215 no 1317 0.390899273642599 1812 600757 SGTC_521 r062-0005 13.8 µM 0.276161446173525 0.406671260996602 no 1318 0.391212033823727 1770 2832033 SGTC_2854 9024559 71.43 µM 0.27571941250769 0.406835192351364 no 1319 0.391381792172032 1756 3163529 SGTC_1293 1000-1278 195 µM 0.274608672034562 0.407247190411687 no 1320 0.39180845153882 1889 678847 SGTC_2026 5148700 152 µM 0.272747608338616 0.407937729697184 no 1321 0.392523617732122 1805 79838 SGTC_48 0382-0018 55 µM 0.272514732173469 0.40802415752881 no 1322 0.392613132571928 1941 762596 SGTC_1500 4488-1866 171 µM 0.272046545887859 0.408197930050565 no 1323 0.39279311502227 1919 2900003 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.270832564065641 0.408648596868784 no 1324 0.39325990652264 1788 229346 A bile salt which induces apoptosis. SGTC_3352 9151559 45.5865 µM 0.26998945342405 0.408961656203313 no 1325 0.393584183681709 1807 17159339 SGTC_1416 3966-0321 25.3 µM 0.26946971888214 0.409154670206175 no 1326 0.393784120741592 1849 582530 YLR208W SEC13 SGTC_2443 5493264 126.67 µM 0.267508360396889 0.409883258651386 no 1327 0.394538888994785 1921 5340055 SGTC_300 r073-0011 5.04 µM 0.267311066972738 0.409956564773119 no 1328 0.39461483324878 1945 2735780 SGTC_1950 st077106 7.18 µM 0.266909403320686 0.410105816188986 no 1329 0.394769458209033 1798 13831864 SGTC_2891 9063876 19.48 µM 0.265711324476322 0.410551079289541 no 1330 0.395230770574595 2007 6472478 SGTC_2389 9091542 195.52 µM 0.265651309304263 0.410573386820443 no 1331 0.39525388288939 1814 3626624 YOL127W RPL25 SGTC_2943 9068529 45.32 µM 0.263451703848603 0.411391175221909 no 1332 0.396101221858644 1887 3270634 SGTC_3256 9138902 49.47 µM 0.263325017211312 0.411438287642857 no 1333 0.396150039481238 1913 17228773 SGTC_2945 9067681 61.76 µM 0.263213024880358 0.411479936586096 no 1334 0.396193196133555 1877 16456930 SGTC_1399 3562-5772 25 µM 0.262853775027711 0.411613545113525 no 1335 0.396331642955087 1844 23847490 SGTC_3116 9124943 49.47 µM 0.262557885757457 0.411723596919856 no 1336 0.39644568185119 1744 41905195 YPL160W CDC60 SGTC_843 0310-0051 143 µM 0.260709550299169 0.412411215862278 no 1337 0.397158250312633 1859 2065037 SGTC_1066 ketoconazole 628 nM 0.26057293101137 0.412462051756627 no 1338 0.397210933304801 1908 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2288 7946289 167.31 µM 0.259480261767808 0.412868685613638 no 1339 0.397632354726209 1945 1246052 SGTC_63 0099-0242 26.702 µM 0.259086075030859 0.413015404100362 no 1340 0.397784414292674 1982 3898502 YLR359W ADE13 SGTC_234 nsc-17383 10.7 µM 0.258841911435992 0.413106289238053 no 1341 0.397878609448977 1936 408974 SGTC_792 4534-1957 155 µM 0.258571359619294 0.413207002315992 no 1342 0.397982991792856 1870 1717904 SGTC_2233 sulbentine 40.3845 µM 0.258428243377083 0.413260279734259 no 1343 0.398038210819251 1912 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_394 menadione 8.33 µM 0.256422400436864 0.414007156009803 no 1344 0.398812346442855 1968 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.255974627308705 0.414173927056219 no 1345 0.398985214618496 1813 6708514 SGTC_2116 5511452 16.8835 µM 0.255223450154988 0.414453734284554 no 1346 0.399275260036609 1888 870744 SGTC_2478 5763493 32.33 µM 0.253262246966894 0.415184470437469 no 1347 0.400032783899633 1901 1365576 YLR208W SEC13 SGTC_2920 7982904 15.77 µM 0.252689936933651 0.415397766208414 no 1348 0.400253912373687 1834 6456808 SGTC_2287 7945887 168.79 µM 0.252277068304673 0.415551654817367 no 1349 0.400413455928091 1989 1245853 SGTC_1983 st071813 46.9 µM 0.251753919250403 0.415746666874314 no 1350 0.400615638674504 1868 11838595 SGTC_974 1326-0144 138 µM 0.25165997788657 0.41578168719759 no 1351 0.40065194725429 1820 5411856 SGTC_6 0844-0013 19.835 µM 0.250362283478221 0.416265521939169 no 1352 0.401153597193417 1954 1584900 SGTC_1638 st008370 60.6 µM 0.250167449976802 0.416338174991531 no 1353 0.401228928105419 1879 24207134 SGTC_898 1000-0849 28.3 µM 0.248828325287468 0.416837609327457 no 1354 0.401746789827768 1996 6751807 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.248053739959882 0.417126556766236 no 1355 0.402046413659897 1896 368090 SGTC_1447 4239-0816 81.9 µM 0.247855202577424 0.417200625372943 no 1356 0.402123220842746 1784 1341554 SGTC_2043 5101342 149 µM 0.247772299504587 0.417231555003031 no 1357 0.402155294266513 1884 678451 SGTC_1045 1348-1485 165 µM 0.247319163395058 0.417400620897795 no 1358 0.402330614561318 1940 6810614 SGTC_14 0354-0009 295 µM 0.247102186383866 0.417481580818608 no 1359 0.402414570852033 1910 1713507 SGTC_1510 1123-0200 71.5 µM 0.246672128188171 0.417642057358185 no 1360 0.40258098929605 1956 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2495 cafestol 54.53 µM 0.244217884758257 0.418558121862236 no 1361 0.403531038163685 1916 16667697 An anti-infammatory. SGTC_93 0109-0045 59.227 µM 0.243641903094163 0.418773175477992 no 1362 0.403754086027471 1993 88733 SGTC_754 3474-0146 171 µM 0.243107276641187 0.418972810071612 no 1363 0.403961147174183 1757 24762078 SGTC_3118 9124250 49.47 µM 0.241421244137758 0.419602527043448 no 1364 0.404614324590233 1857 1504786 SGTC_1763 st044482 94.5 µM 0.241368780062149 0.419622125184723 no 1365 0.404634653710459 1936 88505 SGTC_1233 0325-0408 14.2 µM 0.240768070799257 0.419846536455953 no 1366 0.40486743876653 1946 12874 SGTC_454 lyso-paf C-16 6.67 µM 0.238474905810005 0.420703449631566 no 1367 0.405756388121323 1797 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.238180170751411 0.420813613995665 no 1368 0.405870678032641 1898 521171 SGTC_2150 5556613 200 µM 0.237986578864103 0.420885977025573 no 1369 0.405945751852047 1911 743190 SGTC_3278 9139605 49.47 µM 0.237334244712752 0.421129833746284 no 1370 0.406198748729638 1956 7958859 SGTC_2290 7904846 200 µM 0.236861910188134 0.42130642157708 no 1371 0.406381960222091 1838 2962154 SGTC_29 0299-0004 12.984 µM 0.235998475868356 0.421629267570942 no 1372 0.406716926428813 1980 16871 A napthoquinone isolated from Swertia calycina. SGTC_796 1234-0020 70.7 µM 0.234964502140046 0.422015949116923 no 1373 0.407118142577326 1853 46495034 SGTC_76 0433-0009 400.328 µM 0.234663231364043 0.422128631373638 no 1374 0.407235064003219 1846 2841569 SGTC_2913 7966556 36.57 µM 0.233769174520523 0.422463066860751 no 1375 0.407582090861023 1975 2976516 SGTC_2623 humulene 100 µM 0.232317113267595 0.42300635136668 no 1376 0.408145860772543 1847 6187145 An anti-inflammatory. SGTC_509 pifithrin 175 µM 0.231547002810501 0.423294545460553 no 1377 0.408444937202399 1932 4817 A p53 inhibitor. SGTC_444 curcumin 90.4 µM 0.231282130502171 0.423393676624965 no 1378 0.408547814085923 1947 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2176 5809774 33.9695 µM 0.230942083830641 0.423520949670318 no 1379 0.408679898066475 2034 2870539 SGTC_1583 clindamycin 39.6 µM 0.23090015755546 0.42353664243594 no 1380 0.408696184165246 1813 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3057 9095946 49.47 µM 0.230283769530585 0.423767366943057 no 1381 0.408935635883048 1934 24540043 SGTC_2733 amorolfine 100 µM 0.229946460146663 0.423893638644688 no 1382 0.409066686749538 2050 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2000 st075254 36.4 µM 0.228122870840082 0.424576433945798 no 1383 0.40977536022701 1893 17234175 SGTC_3351 9150312 21.596 µM 0.227970164268283 0.424633621226902 no 1384 0.409834717645414 1999 4904905 SGTC_2840 9008771 71.43 µM 0.22780079585289 0.424697050078776 no 1385 0.409900553980088 2043 2992978 SGTC_2628 lathosterol 100 µM 0.226801572667759 0.425071301038572 no 1386 0.410289020378462 1909 6710616 SGTC_3312 9133330 71.43 µM 0.226378664144931 0.425229718365289 no 1387 0.410453460387405 1978 17617324 SGTC_1351 1496-0003 46.5 µM 0.224989835632966 0.425750044508355 no 1388 0.410993590777646 1986 3891978 SGTC_1335 1486-0900 202 µM 0.224741472830102 0.425843107564792 no 1389 0.411090199571915 1905 X1335 SGTC_2436 5633522 8.09 µM 0.223111186738494 0.426454088017548 no 1390 0.411724486015232 2031 5724242 SGTC_2727 riluzole 51.77 µM 0.222385967184452 0.42672593454147 no 1391 0.412006717449675 2032 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_422 cantharidin 155 µM 0.221225791916257 0.427160895334793 no 1392 0.412458313847299 1819 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2751 anetholtrithion 17.25 µM 0.220986944130847 0.427250452662711 no 1393 0.41255129938007 1998 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2489 cantharidin 73.42 µM 0.219818854123786 0.427688488538365 no 1394 0.413006117642074 1845 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2329 6138490 200 µM 0.219260735966079 0.427897815367795 no 1395 0.413223472929901 1891 720019 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.217718405165795 0.428476384641913 no 1396 0.413824261204579 1922 5355888 SGTC_423 5-fluorouracil 457 µM 0.217567435866637 0.428533025520229 no 1397 0.413883079546563 1787 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2005 4024620 188 µM 0.21731482957015 0.428627802004837 no 1398 0.413981500456169 1933 236743 SGTC_307 1501-1223 22.3 µM 0.217079263879004 0.428716188657733 no 1399 0.414073286843814 1937 2830329 SGTC_1128 3448-9350 235 µM 0.217034616766706 0.428732941113353 no 1400 0.414090683782273 1862 619386 SGTC_642 0335-0876 158 µM 0.216781798411362 0.428827805846161 no 1401 0.414189198715869 1924 6812350 SGTC_1874 staurosporine 7.6 µM 0.216526859268437 0.428923470523215 no 1402 0.414288545517605 1996 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.216353860966432 0.428988389675527 no 1403 0.414355964055989 1920 5106787 A p450 inhibitor. SGTC_1478 0453-0656 35.7 µM 0.215703596032206 0.429232424545626 no 1404 0.414609398988905 1993 5258496 SGTC_2461 5755302 26.15 µM 0.215639865158744 0.42925634326246 no 1405 0.41463423944042 2027 2788904 SGTC_1125 tnp00248 1.32998 µM 0.214102385466693 0.429833450453082 no 1406 0.415233607798264 2051 24207736 SGTC_2703 st077852 53.4 µM 0.213095942440468 0.430211309418952 no 1407 0.415626064714143 1932 6281836 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.21254423160039 0.430418470880574 no 1408 0.415841237062777 1888 6708561 SGTC_1161 k007-0610 110 µM 0.212125435651419 0.430575737026289 no 1409 0.416004588220441 2058 5843850 SGTC_171 k064-0041 9.68 µM 0.211264274300705 0.430899154686578 no 1410 0.416340529360943 1873 53325 SGTC_1946 st076057 65.1 µM 0.210662241382986 0.431125281640485 no 1411 0.416575420185231 1924 953009 SGTC_581 0958-0271 211 µM 0.209818270636037 0.431442319801485 no 1412 0.416904756278623 1889 4591145 SGTC_2446 5162541 200 µM 0.209256842657744 0.431653245065535 no 1413 0.417123870238618 1897 1549321 SGTC_290 2043-6722 48.1 µM 0.207734521372139 0.432225270315484 no 1414 0.417718130729588 1990 773758 YLR208W SEC13 SGTC_1132 3456-3614 2.5 µM 0.207709587275725 0.432234640701645 no 1415 0.417727865688727 2076 3125502 SGTC_2932 9016711 44.54 µM 0.206860475328674 0.432553764890344 no 1416 0.418059412473797 2072 7117328 SGTC_2985 9022375 71.43 µM 0.206681954156112 0.432620864621689 no 1417 0.418129125800883 1947 4939335 SGTC_803 4488-1585 147 µM 0.204290513447084 0.433519908354458 no 1418 0.419063241413543 2029 747204 SGTC_2134 5324836 1.464 µM 0.202547554793058 0.434175377309756 no 1419 0.419744342693718 1975 699272 SGTC_1482 3346-2049 8.48 µM 0.202199384793657 0.434306334250775 no 1420 0.41988042703035 2028 3826804 SGTC_79 0052-0007 94.094 µM 0.198413941344601 0.435730612783629 no 1421 0.421360605330612 2036 2801472 SGTC_3022 9087993 49.47 µM 0.197530291179827 0.436063208170661 no 1422 0.421706289723406 2014 17173644 SGTC_2306 7482397 179.52 µM 0.196933183224274 0.436287978102028 no 1423 0.421939912839176 2038 891448 SGTC_1570 verbenone 133 µM 0.195953244498018 0.436656901954905 no 1424 0.422323380965847 2077 29025 A natural terpanoid with antifungal properties. SGTC_753 1322-0200 289 µM 0.195609066548264 0.436786489939247 no 1425 0.422458081648457 1976 5403907 SGTC_596 1155-0152 116 µM 0.194173494355277 0.437327076669136 no 1426 0.423020018156256 1922 280313 SGTC_2736 butenafine 14.65 µM 0.193720981657782 0.437497501571772 no 1427 0.42319718103291 2054 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1916 st067606 49.2 µM 0.193172967806393 0.437703909551573 no 1428 0.423411754278555 2026 19590279 SGTC_1987 st072290 61.9 µM 0.192524158124137 0.4379483039292 no 1429 0.423665823204402 1969 54697379 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.192066129937875 0.438120848772541 no 1430 0.423845202668192 1979 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1828 st055811 49 µM 0.191844281811628 0.43820442591757 no 1431 0.423932091638134 2090 5877589 SGTC_2657 nystatin 74.44 µM 0.191148554359466 0.438466546121679 no 1432 0.424204604006131 2031 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2326 6164455 177.58 µM 0.190324735637237 0.438776960509636 no 1433 0.424527335830769 1938 2888790 SGTC_2016 5121758 140 µM 0.188979169768526 0.439284049809596 no 1434 0.425054571366875 2054 2795203 SGTC_1630 st005209 31.3 µM 0.188291278470946 0.439543326736879 no 1435 0.42532416092617 2121 3367314 SGTC_1001 4048-4355 44.4 µM 0.186812522480399 0.440100780526181 no 1436 0.425903814122634 1959 21824233 SGTC_189 3970-0742 2.116 µM 0.186777395796658 0.440114023850229 no 1437 0.425917585279883 2080 2891807 SGTC_2759 disulfiram 3.38 µM 0.186692266393098 0.44014611928081 no 1438 0.425950960009376 1959 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1338 1486-1223 76 µM 0.185660583499656 0.440535114876989 no 1439 0.426355470316939 2039 3444526 SGTC_2536 dehydroabietamide 32.04 µM 0.185446151369419 0.440615973637152 no 1440 0.426439556286112 2065 3983547 SGTC_2114 5491910 81.25 µM 0.184525594112158 0.440963128431816 no 1441 0.426800575343404 2040 2849228 SGTC_2411 st077133 39.94 µM 0.183951092511701 0.441179803892209 no 1442 0.427025911305418 2100 1403142 YNL221C POP1 SGTC_1653 st012112 65 µM 0.182828421237597 0.441603274391673 no 1443 0.427466323769104 2066 720429 SGTC_2605 digitonin 300 nM 0.181839186501909 0.441976468106812 no 1444 0.427854465387665 2118 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1881 5652484 16 µM 0.181202036259299 0.442216863491398 no 1445 0.428104498178272 2098 2255129 SGTC_1359 1582-0056 520 nM 0.18094248710527 0.442314796921191 no 1446 0.428206359671912 2040 3661189 SGTC_204 PMA1.184 62.41 µM 0.180873056719699 0.442340995083945 no 1447 0.428233608820053 2071 2252213 YGL008C PMA1 SGTC_1852 st056254 31.4 µM 0.180313257643756 0.442552233235036 no 1448 0.428453324080276 2003 442583 SGTC_1123 mangostin 811.285 nM 0.179709495637122 0.442780078944615 no 1449 0.428690319187375 1938 5281650 An antioxidant. SGTC_976 1348-1067 47.6 µM 0.179649747678755 0.442802627461866 no 1450 0.428713773493405 2023 5310671 YGL099W LSG1 SGTC_471 1-acyl-paf 4 µM 0.179312048750763 0.442930076470531 no 1451 0.428846343322512 1929 16759367 SGTC_2946 9065502 71.43 µM 0.175667145354167 0.444306051622686 no 1452 0.430277724038741 2115 16489101 SGTC_1624 st003710 6.25 µM 0.175206437591238 0.444480019999414 no 1453 0.430458713055116 2080 24207033 SGTC_2088 5278280 127.392 µM 0.172900982254924 0.44535074561075 no 1454 0.431364629777448 2015 791502 SGTC_149 3970-0822 46.1 µM 0.172159872024836 0.445630704731441 no 1455 0.431655922139449 2001 3114250 YBL034C STU1 SGTC_1666 st014829 29 µM 0.170370774796808 0.44630665909288 no 1456 0.432359277222831 1992 3858230 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.169862211657971 0.446498832320362 no 1457 0.432559249955443 1960 6708784 An antioxidant flavonoid SGTC_735 3076-0345 636 µM 0.169838067695179 0.44650795602984 no 1458 0.432568744062466 2085 2888990 SGTC_1362 1611-0397 101 µM 0.16862495499194 0.446966412899936 no 1459 0.433045825198274 2005 27816 SGTC_1774 st048371 48.465 µM 0.167846822145856 0.447260520497721 no 1460 0.433351893121333 1939 4242727 SGTC_1540 guanosine 70.6 µM 0.167153120909289 0.447522740294359 no 1461 0.433624784735878 2102 6802 Guanosine is a purine nucleoside SGTC_1733 st037357 54.9 µM 0.167066721122216 0.447555401113382 no 1462 0.433658775329053 1876 1272339 YGL099W LSG1 SGTC_1379 2144-0755 36.5 µM 0.165936762882284 0.447982580210571 no 1463 0.434103357969409 2122 5392327 SGTC_837 0091-0265 12.5 µM 0.164813989431255 0.448407102868968 no 1464 0.43454519632642 1983 759367 SGTC_3117 9124945 49.47 µM 0.16412619855837 0.448667187048751 no 1465 0.43481589899905 1914 17592065 SGTC_829 1635-0120 117 µM 0.163617851988142 0.448859429578658 no 1466 0.435015995123995 2119 285054 SGTC_2889 9059656 51.95 µM 0.162490329570489 0.44928586997568 no 1467 0.435459871482036 2056 3949838 SGTC_2315 7733312 200 µM 0.160647251634539 0.449983066646746 no 1468 0.436185618385501 1995 726316 SGTC_1174 0739-0097 51.1 µM 0.159856285347128 0.45028231962723 no 1469 0.436497142414031 2025 728447 SGTC_3040 9091894 49.47 µM 0.159781414666684 0.450310647553704 no 1470 0.436526632460503 2089 25236966 SGTC_371 0195-0006 7.36 µM 0.1593025191059 0.450491847538108 no 1471 0.43671526807256 2024 3928593 SGTC_2211 7117706 200 µM 0.158696435490313 0.450721186529251 no 1472 0.436954023327909 2125 822771 SGTC_273 hydroxyurea 18.1 mM 0.158158475745677 0.450924761576337 no 1473 0.437165961705136 2019 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1026 k007-1105 30.6 µM 0.157421023555964 0.45120384964128 no 1474 0.437456522810819 1983 7066794 SGTC_817 1391-0715 46 µM 0.157074513419327 0.451334994404758 no 1475 0.4375930617857 1983 1353946 SGTC_872 0588-0139 234 µM 0.157071841727559 0.451336005588861 no 1476 0.437594114568946 2136 2047100 SGTC_2168 5727979 200 µM 0.155957246582344 0.451757885945209 no 1477 0.438033360531143 2126 695210 SGTC_657 3534-0529 86.7 µM 0.155535210575733 0.451917643128266 no 1478 0.438199698828391 2116 1049549 SGTC_3187 9109394 49.47 µM 0.153409177074955 0.452722548087647 no 1479 0.439037804146113 1987 17098090 SGTC_2731 amoxapine 43.43 µM 0.151880744656612 0.4533013247139 no 1480 0.439640497814895 2177 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2627 acetyl isogambogic acid 100 µM 0.151387354416625 0.453488179690817 no 1481 0.439835082104966 1992 6857789 A caspase activator and apoptosis inducer. SGTC_2666 tannic acid 100 µM 0.1498911139577 0.454054893289392 no 1482 0.440425261273562 2100 16134267 A thiamine antagonist. SGTC_1934 st074720 32.6 µM 0.149847177921535 0.45407153585041 no 1483 0.440442593471757 2097 17250992 SGTC_487 nimodipine 119 µM 0.149616335094661 0.454158978286021 no 1484 0.440533659856294 2155 4497 L-type voltage-gated calcium channels inhibitor SGTC_2226 7298446 200 µM 0.148913329361288 0.454425288007784 no 1485 0.440811011590416 2149 3283010 SGTC_1311 1190-0148 100 µM 0.148083204071935 0.454739779004668 no 1486 0.44113855225418 2114 1961333 SGTC_221 trifluoperazine 10.304 µM 0.147763559187019 0.454860883287643 no 1487 0.441264684565289 2123 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1349 flufenamic acid 69 µM 0.147638480823688 0.454908273036322 no 1488 0.441314042281871 2058 3371 A non-steroidal anti-inflammatory. SGTC_3308 9128332 17.569 µM 0.147225245485565 0.455064844392967 no 1489 0.441477117350632 2135 17332805 YDL196W YDL196W SGTC_118 0083-0097 135.343 µM 0.147101276459204 0.455111816565487 no 1490 0.441526041185604 2033 5207356 SGTC_3092 9117248 49.47 µM 0.146964523166824 0.455163633456196 no 1491 0.441580011310248 2109 17141857 SGTC_3243 9134147 49.47 µM 0.145291107064727 0.455797765403822 no 1492 0.442240517879394 2164 24282180 SGTC_2529 gangaleoidin 93.61 µM 0.144123347568165 0.456240348339312 no 1493 0.442701534249361 2064 4565183 SGTC_2674 ligustilide 100 µM 0.141050277961478 0.45740530525992 no 1494 0.443915111636091 2092 5319022 A signalling regulator. SGTC_543 3844-1095 191 µM 0.13853331986658 0.458359721394903 no 1495 0.444909469017459 2100 4230703 SGTC_123 0083-0120 66.675 µM 0.138233674327082 0.458473361374468 no 1496 0.445027871146977 1959 16001701 SGTC_1498 4478-3555 97.6 µM 0.13773913530321 0.458660921742485 no 1497 0.445223294333931 2176 3437919 SGTC_1279 0874-0590 65.2 µM 0.137439328172169 0.458774631986781 no 1498 0.445341773299154 2094 3523074 SGTC_1884 5633444 25 µM 0.135502275931767 0.459509394156771 no 1499 0.446107382460465 2093 5724239 SGTC_2225 6654152 15.4 µM 0.13459497282018 0.459853599866581 no 1500 0.446466058273702 2142 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2184 6075246 200 µM 0.133749158231738 0.460174505637851 no 1501 0.446800465850529 2100 2267320 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.133650534138922 0.460211925744882 no 1502 0.44683946107631 2155 2346 DNA damaging agent; causes G2/M arrest. SGTC_58 0957-0393 9 µM 0.133363136606558 0.460320972573124 no 1503 0.446953098832672 2090 6997992 SGTC_2865 9030313 51.95 µM 0.131977718583703 0.460846681443803 no 1504 0.447500957781785 2004 42562754 SGTC_319 1348-1596 45.5 µM 0.131574376857685 0.460999745858979 no 1505 0.447660476800511 2174 5380505 SGTC_1817 st052116 64.4 µM 0.128910073539864 0.462010968152613 no 1506 0.448714402824478 2155 4361398 SGTC_591 4299-0174 154 µM 0.128240442406838 0.462265162002552 no 1507 0.448979347931971 2111 5509088 SGTC_1053 3366-3204 134 µM 0.12794500313973 0.462377316480381 no 1508 0.449096248167149 2050 3632071 YPR165W RHO1 SGTC_2273 7815444 169.05 µM 0.127486831608847 0.462551253196117 no 1509 0.44927754749602 2204 2824616 SGTC_486 niguldipine 82 µM 0.127412363108877 0.462579524522051 no 1510 0.449307015821778 2168 1236 A calcium channel blocker. SGTC_7 0192-1582 4.227 µM 0.127170445568646 0.462671367740623 no 1511 0.449402748225577 2133 252616 SGTC_1042 0350-0096 82 µM 0.127144951876748 0.462681046455014 no 1512 0.449412836844726 1981 3122515 SGTC_3097 9117246 49.47 µM 0.125919672729522 0.463146251274356 no 1513 0.449897755019317 2191 16423892 SGTC_1332 1480-0653 17.5 µM 0.124586767177261 0.463652376101693 no 1514 0.450425352514639 2217 5749438 SGTC_361 000s-0510 1.45 µM 0.123804369027322 0.463949492220352 no 1515 0.45073508622399 2090 660 SGTC_89 0302-0250 142.109 µM 0.123693671407275 0.463991531328627 no 1516 0.450778911332056 2214 4203518 YLR208W SEC13 SGTC_2398 5228213 48.84 µM 0.123126240384014 0.464207028209608 no 1517 0.451003566275874 2209 80771 YMR134W ERG29 SGTC_1484 3473-2379 286 µM 0.122827986149361 0.464320302327449 no 1518 0.451121656156786 2187 671917 SGTC_2829 7992743 58.44 µM 0.122691026144343 0.464372319402464 no 1519 0.451175885137599 2232 16462845 SGTC_645 0845-0943 5.41 µM 0.122522297668602 0.464436402902087 no 1520 0.451242694019835 2097 1885106 SGTC_2786 7743617 45.45 µM 0.122408639498166 0.464479571081325 no 1521 0.451287698318436 2042 583674 SGTC_2580 diallyl disulphide 81.36 µM 0.121696684813654 0.464749986012134 no 1522 0.451569619429517 2093 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1185 1319-0113 81.3 µM 0.120930305747645 0.465041090627035 no 1523 0.451873118901941 2115 4672763 SGTC_2425 5628681 7.85 µM 0.120485710046476 0.465209976294801 no 1524 0.45204919945525 2135 5714958 SGTC_441 propafenone 146 µM 0.119224909214455 0.465688942463014 no 1525 0.452548586348701 2172 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2356 9061756 188.97 µM 0.117499209398199 0.466344599746631 no 1526 0.453232235256865 2185 20104043 SGTC_2955 9076254 12.21 µM 0.115113050997044 0.467251339823355 no 1527 0.454177757736303 2190 16459619 SGTC_424 splitomicin 100 mM 0.114714874468513 0.467402663559526 no 1528 0.454335561821549 1999 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2418 pentamidine 31.67 µM 0.11461912677768 0.467439052390538 no 1529 0.454373509325022 2211 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2147 5545932 89.7195 µM 0.113497945417047 0.467865176611444 no 1530 0.454817895938642 2100 797404 SGTC_689 0833-0039 98 µM 0.112292445779944 0.468323388510808 no 1531 0.45529576565767 2183 5374726 SGTC_995 3931-2021 34.6 µM 0.109615857455823 0.469340912194378 no 1532 0.456357017007163 2114 730143 SGTC_184 1494-0393 24.714 µM 0.109572321256463 0.469357464456859 no 1533 0.456374281445454 2130 3090647 SGTC_1464 k208-0027 110 µM 0.108816343612077 0.4696448920944 no 1534 0.456674080234655 2189 X1464 SGTC_3177 9107506 49.47 µM 0.108474512779063 0.46977486361201 no 1535 0.456809648527804 2210 8897194 SGTC_2575 plumbagin 510 nM 0.108066797839105 0.469929889910277 no 1536 0.45697135268025 2104 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_523 1934-0222 13.7 µM 0.106935168256331 0.470360195586525 no 1537 0.457420206454506 2109 1361595 SGTC_2885 9057732 51.95 µM 0.104792581631238 0.471175015230562 no 1538 0.458270198319708 2149 6471414 SGTC_1453 4237-0541 195 µM 0.104783311412193 0.471178540933351 no 1539 0.458273876353151 2229 739892 SGTC_1458 k015-0034 6.33 µM 0.104346504289994 0.471344672475344 no 1540 0.458447187112284 2035 3598957 SGTC_2760 etidronate 98.04 µM 0.104268108796296 0.471374489285777 no 1541 0.458478292713513 2166 3305 A chelator and antioxidant. SGTC_2242 6630449 61.2675 µM 0.102933353631311 0.471882172309707 no 1542 0.459007932959337 2149 691249 YDR170C SEC7 SGTC_936 3005-4620 401 µM 0.102747062217062 0.471953033143142 no 1543 0.459081860512482 2233 777207 SGTC_2817 7995342 71.43 µM 0.101539925188913 0.472412220840357 no 1544 0.459560932801518 2140 18879975 SGTC_3008 9078912 71.4286 µM 0.101136329806497 0.472565754316692 no 1545 0.45972111943576 2148 16648731 SGTC_405 ebelactone b 50 µM 0.100523486089556 0.472798896649521 no 1546 0.459964369034547 2097 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_323 4013-0906 34.3 µM 0.0993377590470448 0.473250005688553 no 1547 0.460435049641703 2239 2910086 SGTC_943 3253-1379 105 µM 0.0993225716812122 0.47325578393522 no 1548 0.460441078707742 2192 668464 SGTC_391 gliotoxin 8.33 µM 0.0992402586353026 0.473287101187655 no 1549 0.460473755420576 2167 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2689 tacrolimus 100 µM 0.0991673318991592 0.473314847413477 no 1550 0.460502706170065 2127 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_675 1309-0189 238 µM 0.0987163170344507 0.47348644661463 no 1551 0.460681756513492 2113 4246530 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0985723174821671 0.473541235665064 no 1552 0.460738925199765 2215 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1425 4048-4433 7.33 µM 0.0983273736322207 0.473634433221753 no 1553 0.460836171241397 2235 23734946 SGTC_747 3448-8087 38.7 µM 0.0981814412517413 0.473689959047031 no 1554 0.460894109496057 2151 5168703 SGTC_1912 st060209 90.8 µM 0.097351315380703 0.474005823410337 no 1555 0.461223702854388 2116 688787 SGTC_1308 1187-1617 41.4 µM 0.0964693783719738 0.474341419902724 no 1556 0.461573896495498 2195 2882570 SGTC_504 lovastatin 124 µM 0.095824930515707 0.474586658059465 no 1557 0.461829808390575 2069 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2875 9039966 71.43 µM 0.0957641409315174 0.474609791423417 no 1558 0.461853948907565 2201 6463691 SGTC_1711 st032263 62.8 µM 0.0947323237861524 0.475002460526615 no 1559 0.46226372137803 2147 3958979 SGTC_2743 auranofin 4.32 µM 0.094617449708416 0.475046178600579 no 1560 0.46230934457768 2200 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1428 4049-0204 61.7 µM 0.0938951125345086 0.47532108812796 no 1561 0.46259623815944 2235 X1428 SGTC_2961 9083290 32.55 µM 0.0938457463502943 0.475339876507902 no 1562 0.46261584583888 2251 17741490 SGTC_848 0368-0089 85.6 µM 0.0933738980747777 0.475519460996992 no 1563 0.462803263112731 2238 762535 SGTC_541 4513-1321 94 µM 0.0928835112483353 0.475706106490365 no 1564 0.46299805261509 2056 747515 SGTC_2258 7960471 200 µM 0.0928808355972488 0.475707124881111 no 1565 0.462999115450939 2083 2974708 SGTC_3301 9125354 19.7965 µM 0.0924941108842599 0.475854319456618 no 1566 0.463152734999322 2210 41905162 SGTC_435 c-PAF 6.7 µM 0.0922176887927979 0.475959532835674 no 1567 0.463262542152239 2248 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2210 7115885 190.385 µM 0.0919055005577121 0.476078361746846 no 1568 0.463386560574058 2212 2927039 SGTC_2321 7390090 138.78 µM 0.091775605599937 0.476127804584592 no 1569 0.463438163079646 2111 649046 SGTC_1671 st016596 74.5 µM 0.0915633669963395 0.476208591258 no 1570 0.463522479020852 2236 2829167 SGTC_233 rapamycin 362 pM 0.0907887151709332 0.476503463628089 no 1571 0.463830238503566 2245 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1854 st056233 32.9 µM 0.0907834271092631 0.476505476581033 no 1572 0.463832339458929 2252 5393174 SGTC_3153 9100258 49.47 µM 0.0888774279239603 0.477231052662813 no 1573 0.464589661227415 2156 25236848 SGTC_2427 5545055 42.75 µM 0.0885827873843943 0.477343223268655 no 1574 0.464706743989223 2187 5372858 SGTC_2163 5671233 125 µM 0.0882517838178468 0.477469239537008 no 1575 0.464838280150492 2241 701023 SGTC_919 tnp00227 403.569 nM 0.0879390538280148 0.47758830094744 no 1576 0.464962558179771 2170 1269246 A methoxyflavone. YNL221C POP1 SGTC_413 propylparaben 100 µM 0.087633714478697 0.47770455055056 no 1577 0.465083902486765 2125 7175 A pharmaceutical preservative. SGTC_1147 3809-1045 12.3 µM 0.0870073927541693 0.47794301133687 no 1578 0.465332817913488 2118 325925 SGTC_2135 5326629 150.42 µM 0.0867241031579925 0.478050871378939 no 1579 0.46544540852317 2166 5020077 SGTC_2363 9053361 176 µM 0.086487335449748 0.478141019851753 no 1580 0.46553951159738 2253 6469797 YMR079W SEC14 SGTC_452 diindolylmethane 8 µM 0.0862186288191712 0.478243330311638 no 1581 0.465646311096526 2212 3071 Inhibits expression of several cancer promoting factors. SGTC_856 0433-0016 11.3 µM 0.0862150384425348 0.478244697362747 no 1582 0.465647738135864 2159 3911780 SGTC_190 3970-0790 3.722 µM 0.0848587749316651 0.47876111860421 no 1583 0.466186833179522 2266 2832352 SGTC_2787 5284540 71.43 µM 0.0846398785546693 0.478844470623445 no 1584 0.466273847150703 2164 736958 SGTC_1173 0443-0020 122 µM 0.082868467996504 0.479519027374302 no 1585 0.466978063335647 2184 5331295 SGTC_2740 felodipine 17.08 µM 0.0818630336804309 0.479901925032641 no 1586 0.467377815293319 2278 3333 L-type calcium channel blocker SGTC_1246 0422-0085 105 µM 0.0814706067661719 0.480051377287305 no 1587 0.467533849778213 2258 264295 SGTC_2452 5863136 48.41 µM 0.0813666241025048 0.48009097861876 no 1588 0.467575195591289 2246 2184096 SGTC_3136 9095672 49.47 µM 0.0807235301561564 0.480335902416966 no 1589 0.467830911760984 2276 17217380 SGTC_622 1348-1566 26.3 µM 0.0789098587702592 0.481026682997004 no 1590 0.468552160765864 2223 7340407 SGTC_3302 9125395 16.351 µM 0.0778600369376131 0.481426559181987 no 1591 0.468969694385319 2174 17599668 SGTC_2923 7992654 58.14 µM 0.077686177327147 0.481492783964648 no 1592 0.46903884488434 2205 2985126 SGTC_3304 9125678 46.087 µM 0.0756284674815137 0.482276623549182 no 1593 0.469857343771178 2234 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2958 9077254 16.72 µM 0.0751882063699619 0.482444340396531 no 1594 0.470032483873158 2184 16457351 SGTC_660 4031-1742 102 µM 0.075029142761055 0.48250493621879 no 1595 0.470095762333196 2228 6738706 SGTC_864 0469-0573 172 µM 0.0750253742232695 0.482506371860971 no 1596 0.470097261536735 2116 689425 SGTC_2249 haloperidol 116.36 µM 0.0750210071854587 0.482508035504832 no 1597 0.470098998836693 2221 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0742753110134329 0.482792116456849 no 1598 0.470395660856709 2290 16725076 SGTC_624 k048-0052 28 µM 0.0728944294706244 0.483318201047205 no 1599 0.470945063395432 2188 6835531 SGTC_2531 methyl deoxycholate 70.07 µM 0.07220675001411 0.483580202234742 no 1600 0.471218686731921 2212 16667744 Haematoxylin. SGTC_1044 1222-0021 1.78 µM 0.0714210931930966 0.483879540801426 no 1601 0.471531311267655 2205 4306703 SGTC_232 clozapine 119 µM 0.0710665965005386 0.484014608523183 no 1602 0.471672376529734 2284 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2342 7990637 118.86 µM 0.0702516128208762 0.484325134539612 no 1603 0.471996697337326 2210 2033102 YER133W GLC7 SGTC_490 phenamil 164 µM 0.0690445993284917 0.484785049615989 no 1604 0.472477059524763 2275 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3267 9137951 49.47 µM 0.0689093949152299 0.484836568578874 no 1605 0.472530870118561 2143 16643986 SGTC_977 1348-1378 135 µM 0.0688924934806786 0.484843008803473 no 1606 0.472537596829445 2285 X977 SGTC_904 1141-0088 396 µM 0.068709368556613 0.484912788082597 no 1607 0.47261048040018 2126 1378119 SGTC_2805 7950783 58.44 µM 0.068401489011961 0.485030105827798 no 1608 0.47273301827411 2230 1178958 YDL195W SEC31 SGTC_1386 3228-0095 33.8 µM 0.0670587079891823 0.485541788620805 no 1609 0.473267483057524 2263 870181 SGTC_41 0478-0632 82.643 µM 0.0660496076196216 0.48592633411759 no 1610 0.473669165240486 2292 3750424 SGTC_638 3970-0837 4.09 µM 0.065496322674926 0.486137184166894 no 1611 0.473889417065776 2233 4118451 YLR208W SEC13 SGTC_249 wiskostatin 11.211 µM 0.0649736262913114 0.486336380854997 no 1612 0.474097499521218 2283 2775510 A n-wasp and actin depolymerizer. SGTC_3184 9108758 49.47 µM 0.0648607172935142 0.486379410296287 no 1613 0.474142448880721 2276 902885 SGTC_727 3032-0951 202 µM 0.0644412414141971 0.486539273278446 no 1614 0.474309446175028 2226 3652836 SGTC_2836 9010338 19.48 µM 0.0640716379007958 0.486680131609293 no 1615 0.474456592553286 2224 2994051 SGTC_545 4218-0007 221 µM 0.0631328754872586 0.487037907571968 no 1616 0.474830347826359 2232 2840508 SGTC_283 0987-0079 11.7 µM 0.0615430179890503 0.487643848952524 no 1617 0.475463377956211 2270 411556 SGTC_2053 5265679 138 µM 0.0605162595132816 0.488035192006784 no 1618 0.475872233182072 2291 764595 SGTC_212 3807-4682 38.772 µM 0.0604661387243224 0.488054295553565 no 1619 0.475892191934102 2269 3125501 YBL034C STU1 SGTC_1422 4031-0024 15.5 µM 0.0603904652634151 0.48808313855729 no 1620 0.475922326208047 2300 782427 SGTC_1075 aripiprazole 15.2 µM 0.0598826967318249 0.488276676568025 no 1621 0.476124530584225 2273 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2359 9039622 200 µM 0.0584702633485948 0.488815045590396 no 1622 0.476687024183901 2264 6463596 SGTC_2741 miltefosine 3.04 µM 0.057951342327745 0.489012844870779 no 1623 0.476893693271355 2273 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1278 0874-0585 172 µM 0.0560694249495676 0.489730205446494 no 1624 0.477643250481638 2258 766306 SGTC_1897 st060201 15 µM 0.0560548071955497 0.489735777662848 no 1625 0.477649072964648 2150 611878 SGTC_992 3909-8734 162 µM 0.0557181674345547 0.489864103645755 no 1626 0.477783163232319 2275 4288319 SGTC_1420 4'-methoxyflavone 42 µM 0.0546897388666235 0.490256143716154 no 1627 0.478192822163632 2308 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1211 1056-0033 32.3 µM 0.0543384778917496 0.490390047634417 no 1628 0.478332746949301 2308 6741922 SGTC_3098 9119039 49.47 µM 0.051910311139163 0.491315715968707 no 1629 0.479300079126875 2319 17161528 SGTC_1027 k015-0025 8.67 µM 0.0515260241928373 0.491462218665657 no 1630 0.479453182541525 2329 3598955 SGTC_3330 9141424 71.43 µM 0.0514510673181343 0.491490794801865 no 1631 0.479483046396207 2296 27261020 SGTC_1791 st048313 56.1 µM 0.0505621663308783 0.491829677690835 no 1632 0.479837205568164 2327 1204976 SGTC_1717 st033143 58.0435 µM 0.0492835351785608 0.492317150832045 no 1633 0.480346670298279 2322 674616 SGTC_2893 9048488 25.97 µM 0.0483721005842267 0.492664638764423 no 1634 0.480709846888289 2278 6467338 SGTC_879 0831-1030 162 µM 0.0462375336617769 0.493478471907651 no 1635 0.481560463458265 2324 1549252 SGTC_651 3253-0966 34.4 µM 0.04621518975013 0.493486990982273 no 1636 0.481569367870432 2302 781462 SGTC_368 fentichlor 4.58 µM 0.0458624386490098 0.493621484966109 no 1637 0.481709946136518 2267 7329 A pesticide. SGTC_885 0865-0106 16.8 µM 0.0456325962079457 0.493709117757081 no 1638 0.481801544103989 2304 2793380 SGTC_21 0849-0113 22.993 µM 0.0450021572051222 0.493949488875651 no 1639 0.482052794748489 2307 1560156 SGTC_2710 st078562 53.7235 µM 0.0439735968588853 0.494341658693949 no 1640 0.482462725078558 2330 17250908 SGTC_343 4130-2827 29.8 µM 0.0439033584354768 0.494368439426293 no 1641 0.482490719119807 2268 1118244 SGTC_495 decylubiquinone 155 µM 0.0431529746271947 0.494654549741708 no 1642 0.482789795476022 2203 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3129 9127257 49.47 µM 0.0430732323077185 0.494684954480115 no 1643 0.48282157850687 2217 837894 SGTC_787 4152-0075 138 µM 0.0427391227876823 0.494812346550339 no 1644 0.482954746286695 2207 9566539 SGTC_1879 gemcitabine 100 µM 0.0425583356119819 0.494881278817084 no 1645 0.483026804371196 2317 60750 A nucleoside analog which inhibits DNA replication. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0419845064943921 0.49510007488434 no 1646 0.483255524626452 2317 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1179 1021-1431 9.29 µM 0.0405408110367878 0.495650549817145 no 1647 0.483830985634026 2282 2840958 SGTC_2044 5102272 200 µM 0.0404203157054625 0.495696494563025 no 1648 0.483879016946248 2291 592666 SGTC_167 3672-0051 66.205 µM 0.0396355398529867 0.495995730157438 no 1649 0.48419184649278 2335 3237971 SGTC_1937 st074714 47.2 µM 0.0391281777202383 0.496189188911597 no 1650 0.484394097797125 2320 17250970 SGTC_1994 st072947 40.9 µM 0.0379226746824724 0.496648854467959 no 1651 0.484874667134064 2271 5286565 YDL195W SEC31 SGTC_389 tpck 16.7 µM 0.036917639473262 0.497032083862747 no 1652 0.485275337534233 2303 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2231 micatex 6.853 µM 0.0368958330506011 0.497040398888805 no 1653 0.485284031115405 2281 20737 An antifungal of unknown mechanism. SGTC_68 0986-0284 82.829 µM 0.0363954953636119 0.497231183434869 no 1654 0.485483502990308 2130 423278 YIL048W NEO1 SGTC_1524 corynanthine 62.1 µM 0.0355949120960528 0.497536456392031 no 1655 0.485802682655894 2264 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1679 SEC14.276 6.7 µM 0.0354526555202694 0.49759070085637 no 1656 0.485859399020997 2336 1005053 YMR079W SEC14 SGTC_2624 nerol 100 µM 0.0354382060450141 0.49759621065019 no 1657 0.485865159907541 2331 637566 A natural product oil. SGTC_853 0419-0306 21 µM 0.0353206038699822 0.497641054076737 no 1658 0.485912047033855 2305 762713 SGTC_2723 salbutamol 83.58 µM 0.0351819998292842 0.497693905859551 no 1659 0.48596730770026 2336 9884233 β2-adrenoceptor agonist SGTC_1397 3532-0190 20.1 µM 0.0349832657477698 0.497769686191908 no 1660 0.486046542352142 2319 5322280 SGTC_1119 parthenolide 318.541 nM 0.0337690509314877 0.498232686442761 no 1661 0.486530657821073 2307 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2397 5161689 200 µM 0.0330883850047521 0.498492236732731 no 1662 0.486802052551488 2320 2259942 SGTC_1367 1812-0510 76.9 µM 0.0327027468099641 0.498639287876211 no 1663 0.48695581671336 2326 1142582 YDR527W RBA50 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0326311187722488 0.498666601023806 no 1664 0.486984376923288 2343 688667 SGTC_1713 st033146 12.748 µM 0.0323452400084768 0.498775612152496 no 1665 0.487098365876328 2343 674619 SGTC_2256 7954252 200 µM 0.0322260730261088 0.498821052866351 no 1666 0.487145881853078 2240 2972920 SGTC_227 fluconazole 33.516 µM 0.031801911794024 0.49898279400552 no 1667 0.487315011008912 2324 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2686 alizarin 95.37 µM 0.031577138360298 0.499068504669156 no 1668 0.487404637620961 2309 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_662 k832-1615 104 µM 0.0315263466300712 0.499087872590904 no 1669 0.487424890506132 2319 5878478 SGTC_1369 1866-0067 208 µM 0.0315226011950659 0.49908930080168 no 1670 0.48742638397623 2332 3531355 SGTC_2029 5175081 200 µM 0.0310463351634841 0.499270910844397 no 1671 0.487616293674395 2338 1380876 SGTC_1305 1181-0477 144 µM 0.0303325357194694 0.49954309753857 no 1672 0.487900924376238 2343 6252086 SGTC_1681 tripelennamine 100 µM 0.0300551313919909 0.499648877689307 no 1673 0.488011542256019 2372 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1688 st021091 57.6 µM 0.0298304360524944 0.499734558803993 no 1674 0.488101142551479 2356 3656366 SGTC_222 nsc-310342 10.666 µM 0.0297081183095011 0.499781201167837 no 1675 0.488149918653052 2348 432556 SGTC_429 1112-0049 25.5 µM 0.0295351253749876 0.499847167067818 no 1676 0.48821890257747 2316 2836170 SGTC_1284 0929-0043 16 µM 0.0291920442530826 0.499977991236286 no 1677 0.488355713148806 2319 1239883 SGTC_2778 tioconazole 65.09 nM 0.0290766100603997 0.499977991236286 no 1678 0.488401745188495 2335 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0287951884064408 0.499870679140711 no 1679 0.488513969192865 2296 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_852 0418-0143 439 µM 0.0286011413939032 0.499796684869622 no 1680 0.488591350878683 2360 5369229 SGTC_336 4111-0029 111 µM 0.0283620698758003 0.49970552180264 no 1681 0.488686687938424 2269 3131175 SGTC_2408 sulbentine 18.36 µM 0.0280779103641025 0.499597165742791 no 1682 0.488800006051203 2243 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2314 7727897 200 µM 0.0278216757732461 0.499499458073885 no 1683 0.488902188942947 2346 900724 SGTC_526 4469-0568 170 µM 0.0274722516587932 0.499366215318189 no 1684 0.489041535729929 2353 2901964 SGTC_3239 9133757 49.47 µM 0.0269563505986701 0.49916949153925 no 1685 0.489247274272074 2352 17036923 SGTC_1376 2910-0861 41.3 µM 0.0262784095034515 0.498910978847341 no 1686 0.489517637842181 2361 1112859 SGTC_2991 9074669 71.4286 µM 0.0260135856377039 0.498809996253488 no 1687 0.489623251173275 2353 17333109 SGTC_3217 9129673 49.47 µM 0.0254571603081882 0.498597820492558 no 1688 0.489845159262166 2347 17248312 SGTC_2523 spermine 47.74 µM 0.0254192553237834 0.498583366601207 no 1689 0.489860276271164 2358 1103 A DNA binding polyamine. SGTC_2595 hexamethylquercetagetin 100 µM 0.0243558386254648 0.498177866419951 no 1690 0.490284386768591 2341 386331 SGTC_572 0960-0087 17.7 µM 0.0240180007029082 0.498049043032813 no 1691 0.490419125181953 2352 6796365 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0238038917868851 0.497967399739852 no 1692 0.49050451786659 2336 5379071 SGTC_933 2914-0560 114 µM 0.0235595184483288 0.497874216223134 no 1693 0.490601981389569 2368 463887 SGTC_3138 9097216 49.47 µM 0.0217645355577882 0.497189764024003 no 1694 0.491317892003312 2381 25237486 SGTC_3161 9100388 49.47 µM 0.0212039056890787 0.496975989577795 no 1695 0.491541499347298 2359 25236368 SGTC_340 k038-0059 454 µM 0.0207133819715049 0.496788948102134 no 1696 0.491737147020534 2376 23733424 SGTC_2357 9067248 200 µM 0.0199510756445215 0.496498274683798 no 1697 0.492041200383371 2330 9150235 SGTC_1843 st055809 45.5 µM 0.019319834125523 0.496257578711456 no 1698 0.492292980768485 2322 16413835 SGTC_1468 k284-1086 134 µM 0.0190489156093057 0.496154276356965 no 1699 0.492401041731596 2362 15996457 SGTC_2835 9006588 71.43 µM 0.0189467960115823 0.496115337797124 no 1700 0.492441774205553 2307 2345538 SGTC_2611 pyromycin 23.93 µM 0.0182234945703984 0.495839541508337 no 1701 0.492730279895293 2362 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_840 0245-0196 390 µM 0.0180231949985234 0.495763167226206 no 1702 0.492810174741093 2351 3827528 SGTC_1710 st031758 61.5 µM 0.0178705313628171 0.495704956643842 no 1703 0.492871068912509 2374 5394341 SGTC_700 3453-2283 142 µM 0.0177417943638398 0.49565586934938 no 1704 0.492922419403193 2353 565664 SGTC_1940 st075990 51.1 µM 0.0169087879704141 0.495338246431551 no 1705 0.493254690991758 2324 1084979 SGTC_1767 st044992 70.3 µM 0.0165368908617409 0.495196444086619 no 1706 0.49340303572751 2366 9600693 SGTC_2299 7976368 114.88 µM 0.0161228055057933 0.495038556307373 no 1707 0.493568209858052 2359 2979718 SGTC_1848 st056003 16.4 µM 0.0150863588299084 0.494643370077609 no 1708 0.493981641900909 2384 146492 SGTC_895 0964-0006 13.7 µM 0.0147971684038018 0.494533105727425 no 1709 0.494096999310715 2373 6738897 SGTC_223 busulfan 5 mM 0.0143672543622549 0.494369186163841 no 1710 0.494268491963362 2364 2478 A DNA alkylator. SGTC_1749 st037932 54.2 µM 0.0131772378801202 0.493915456358825 no 1711 0.494743194802743 2362 594497 SGTC_548 1436-0017 110 µM 0.0127728306586751 0.493761265627089 no 1712 0.494904516360842 2387 9677137 SGTC_2968 9090663 33.37 µM 0.0122547602861752 0.493563739238927 no 1713 0.49511118035243 2336 25236811 SGTC_533 1222-0222 6.71 µM 0.0112673718219022 0.49318727881492 no 1714 0.495505064099541 2375 3982874 SGTC_2032 5185112 25.99 µM 0.0108673527379054 0.493034765723193 no 1715 0.495664638850874 2385 5718189 SGTC_984 1492-0255 2.91 µM 0.0107703727613019 0.492997790849597 no 1716 0.49570332599969 2372 1585198 SGTC_1742 st038235 28.8875 µM 0.0101947226689764 0.492778318036729 no 1717 0.49593296453994 2366 564103 YBR002C RER2 SGTC_1600 coumarin 106 71.1 µM 0.00991653950588355 0.492672258481695 no 1718 0.496043937954315 2361 100336 A hepatotoxic, DNA x-linker. SGTC_1098 clofazimine 15.1 µM 0.00923908446934164 0.49241397551453 no 1719 0.496314191010249 2377 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3268 9137683 49.47 µM 0.00700832554729633 0.491563511088398 no 1720 0.497204105511869 2393 1953228 SGTC_82 0054-0107 293.755 µM 0.00634631048690459 0.491311128735273 no 1721 0.497468205417178 2388 3104697 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.00594512879133269 0.491158186498617 no 1722 0.497628250734118 2385 6857784 SGTC_291 SEC14.278 35.5 µM 0.00577870986081522 0.491094743098238 no 1723 0.497694641141017 2398 1068044 SGTC_1175 0741-0056 27.6 µM 0.00543786701243133 0.490964805284624 no 1724 0.497830615625139 2391 765927 SGTC_1433 4060-0023 7.6 µM 0.00501059621392601 0.490801920332018 no 1725 0.498001069684465 2394 3840627 SGTC_230 MPP+ 141.667 µM 0.00449900541891323 0.490606892776794 no 1726 0.498205162573541 2390 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2143 5623677 140.463 µM 0.00338655277708502 0.490182813759438 no 1727 0.498648963494858 2397 5375313 SGTC_917 harmaline 728.087 nM 0.00331310955236698 0.490154816790563 no 1728 0.49867826293801 2392 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2540 epiandrosterone 100 µM 0.00310022859868484 0.490073665652491 no 1729 0.498763189714325 2398 441302 A steroid. SGTC_930 2810-3379 265 µM 0.00257854281860232 0.489874798526333 no 1730 0.498971311387773 2399 1015764 SGTC_2883 9059145 45.46 µM 0.00244980347527449 0.489825723348898 no 1731 0.499022670792618 2399 16476510 SGTC_1631 benzylvanillin 81.9 µM 0.00151375244623502 0.48946890726682 no 1732 0.49939610037777 2395 75506 SGTC_1802 st050112 57.9 µM 0.000933623213430951 0.489247770287463 no 1733 0.499627538280308 2397 4662563 SGTC_2712 st079126 47.7 µM 0.000686263779939075 0.48915348140485 no 1734 0.499726220384164 2402 3152970 SGTC_715 0868-0130 184 µM 0.000531244612308564 0.489094391247883 no 1735 0.499788064072883 2404 2876258 SGTC_2117 5521686 200 µM 0 0.488891893419407 no 1736 0.5 2405 803312 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0016622732187872 0.488258293085773 no 1737 0.499336849236845 2410 77254 SGTC_3242 9133940 49.47 µM -0.00260587116975207 0.487898639676707 no 1738 0.498960408989675 2414 17248444 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.00311273116665865 0.487705453469032 no 1739 0.498758201935414 2413 688662 SGTC_652 0437-0092 114 µM -0.00338464637687357 0.487601816039689 no 1740 0.498649724034147 2409 3091274 SGTC_1972 st070201 17.4 µM -0.00342513172507949 0.487586385575223 no 1741 0.498633572810635 2413 2829099 SGTC_2775 cyproheptadine 69.59 µM -0.00410298306031795 0.487328034123994 no 1742 0.49836315117405 2412 2913 A selective serotonin reuptake inhibitor. SGTC_3207 9114163 49.47 µM -0.00452456530736882 0.487167357931071 no 1743 0.498194965757139 2422 849233 SGTC_656 4090-1979 187 µM -0.00466330053798755 0.487114482703689 no 1744 0.498139618991937 2415 22330961 SGTC_1527 coumarin 137 µM -0.00690290620005479 0.486260948818725 no 1745 0.497246160729296 2438 323 A hepatotoxic, DNA x-linker. SGTC_491 tetrandrine 80.3 µM -0.00840915236503085 0.485686939998765 no 1746 0.496645273116903 2422 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_65 0798-0905 34.986 µM -0.00861409841571547 0.485608840262514 no 1747 0.496563514433898 2429 3602145 SGTC_613 3914-0030 117 µM -0.00919023207105206 0.485389293321462 no 1748 0.496333679470024 2399 1145395 SGTC_1130 3454-2858 15.9 µM -0.0105881553157624 0.484856606006511 no 1749 0.495776016097691 2450 715628 YIL048W NEO1 SGTC_2338 7999974 200 µM -0.0107115009374726 0.48480960567657 no 1750 0.495726811104585 2441 315925 SGTC_1021 4476-0760 85.3 µM -0.0107588998281522 0.484791544584893 no 1751 0.495707902772623 2428 746768 SGTC_1579 chlormadinone acetate 49.4 µM -0.0110983834709198 0.484662187087855 no 1752 0.495572476482244 2426 45114258 A steroidal progestin. SGTC_866 0495-0101 262 µM -0.0111582296568149 0.484639383349604 no 1753 0.495548602786669 2431 635694 SGTC_408 cantharidin 100 µM -0.0116893034662722 0.484437025659954 no 1754 0.495336748816733 2445 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1673 st016611 27.3 µM -0.0117476158854955 0.484414806832689 no 1755 0.495313487124465 2448 5226799 SGTC_2680 butyl paraben 22.24 µM -0.0117782890637018 0.484403119426729 no 1756 0.495301251143362 2425 7184 An antifungal and steroid mimetic. SGTC_1518 st038567 90.8 µM -0.0119576108099283 0.48433479270179 no 1757 0.495229717154988 2425 77966 SGTC_2254 7938975 95.19 µM -0.0121013868946355 0.484280010224835 no 1758 0.495172362945918 2444 2969277 SGTC_714 4296-0578 26.1 µM -0.0124006426222491 0.484165986859605 no 1759 0.495052986142777 2440 1589775 SGTC_3154 9100113 49.47 µM -0.0135680622337546 0.483721185405679 no 1760 0.494587292385324 2432 25237525 SGTC_2371 9071574 200 µM -0.0144788531194264 0.483374176741307 no 1761 0.494223975131245 2436 45596039 SGTC_3257 9139206 32.98 µM -0.0155822010485142 0.482953821299272 no 1762 0.493783852732979 2430 4910041 SGTC_1793 st048256 72.231 µM -0.0157199436915136 0.482901345184745 no 1763 0.493728908098838 2430 672022 SGTC_1197 1601-0112 267 µM -0.0173330074463757 0.482286835061538 no 1764 0.493085476710193 2440 7350313 SGTC_2136 5328288 199.296 µM -0.0188818265664045 0.481696839050304 no 1765 0.492467688628291 2443 262395 SGTC_2434 5670830 169.91 µM -0.0197315908391711 0.481373152909828 no 1766 0.492128744918058 2468 1549830 SGTC_74 000s-0487 160.283 µM -0.0208312097770029 0.480954312171151 no 1767 0.491690150667423 2440 677548 SGTC_2819 7996655 46.38 µM -0.0210571844849035 0.480868241839526 no 1768 0.491600019572925 2448 6456960 SGTC_2996 9066192 71.4286 µM -0.0211040484295341 0.480850392186834 no 1769 0.491581327717708 2462 6472854 SGTC_1492 4158-0558 28.5 µM -0.0218903266959164 0.480550918371158 no 1770 0.491267720553031 2465 3967268 SGTC_1855 st056195 39.6 µM -0.0220331231612943 0.480496531925518 no 1771 0.49121076674211 2455 4028379 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0225363008430045 0.480304891107229 no 1772 0.491010077730549 2449 688803 SGTC_926 2268-1401 59.4 µM -0.0239002184312433 0.479785450938432 no 1773 0.490466100025345 2446 2931578 SGTC_314 1671-0008 2.74 µM -0.0239824664570363 0.479754128339454 no 1774 0.490433297212821 2452 3913060 SGTC_3013 9080133 71.4286 µM -0.0263887090700795 0.478837812663786 no 1775 0.489473649936056 2479 17050193 SGTC_2974 9094440 9.66 µM -0.026703959476221 0.47871777106919 no 1776 0.489347927527243 2621 25236134 SGTC_2640 pentamidine 10.38 µM -0.0267437057382296 0.478702636555655 no 1777 0.489332076723882 2466 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1796 st049173 110.4 µM -0.028714425403802 0.477952268250269 no 1778 0.488546175651771 2454 94134 SGTC_1198 1612-1005 86.7 µM -0.028758870338253 0.477935346353912 no 1779 0.488528452007829 2487 6998509 SGTC_707 0865-0008 204 µM -0.0294989932604923 0.477653558954814 no 1780 0.488233310927568 2472 723043 SGTC_3036 9090181 49.47 µM -0.0310599235672543 0.477059301914717 no 1781 0.487610875298699 2456 25236586 SGTC_2007 4011539 71.82 µM -0.0310960318937936 0.477045555821864 no 1782 0.487596477115424 2459 45595301 SGTC_554 4483-2211 187 µM -0.0311012443213848 0.477043571503036 no 1783 0.487594398662979 2507 747107 SGTC_2181 6316240 54.2555 µM -0.03110619440691 0.477041687055724 no 1784 0.487592424819591 2480 12779990 SGTC_1217 1183-1422 255 µM -0.031383233423681 0.476936221933845 no 1785 0.487481956177516 2494 2849664 SGTC_119 0121-0043 24.815 µM -0.0316093441865962 0.47685014572752 no 1786 0.487391795765715 2460 1092378 SGTC_611 3453-1652 23.7 µM -0.0320407042847335 0.476685937875616 no 1787 0.487219795111779 2465 1560575 SGTC_1408 3909-7976 48.8 µM -0.0325826844700697 0.476479625376555 no 1788 0.487003689145044 2474 24152374 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.032721514567464 0.476426778729103 no 1789 0.486948333466306 2472 2724278 An inhibitor of dopamine biosynthesis. SGTC_1102 cgs 12066b 26.1 µM -0.0329341333297371 0.476345844714384 no 1790 0.486863556545501 2513 6438352 A 5-HT1B full agonist. SGTC_136 0097-0015 404.482 µM -0.0337125579535201 0.476049543232573 no 1791 0.486553182433397 2453 4861337 SGTC_571 k831-0106 44.2 µM -0.0346803622018367 0.47568117430636 no 1792 0.486167310099759 2479 4783639 SGTC_2412 st077135 33.4 µM -0.0351104296259619 0.475517487240405 no 1793 0.485995842451065 2668 13258915 SGTC_1773 st048542 73.5835 µM -0.0360610948938824 0.475155671215136 no 1794 0.485616821957072 2468 3237138 SGTC_2783 7738165 71.43 µM -0.0360822990697947 0.475147601298304 no 1795 0.485608368216434 2483 17201110 SGTC_2772 vinpocetine 57.06 µM -0.0381842912556427 0.474347673120342 no 1796 0.484770372762062 2490 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_70 0141-0289 43.283 µM -0.0389950282890222 0.474039168794649 no 1797 0.484447176225591 2572 352408 SGTC_2291 7917025 104.35 µM -0.0391413196010484 0.473983503195477 no 1798 0.484388858958478 2482 2964612 SGTC_842 0271-0008 11.1 µM -0.0401349914565457 0.473605412632567 no 1799 0.483992752558914 2566 1221709 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0406557950643789 0.473407257161562 no 1800 0.483785151431918 2483 803109 SGTC_1554 st069299 38.7 µM -0.0414607557609339 0.473100998501269 no 1801 0.483464289150595 2514 24207999 SGTC_1841 st054148 70 µM -0.0418344393957044 0.472958830680092 no 1802 0.483315340183747 2519 675442 SGTC_1413 3910-0535 34.4 µM -0.0420710387581389 0.472868818306904 no 1803 0.483221033722513 2527 2876951 SGTC_2914 7968218 45.32 µM -0.0422105374316896 0.472815747778755 no 1804 0.483165431196306 2515 2977111 SGTC_2644 guaiazulene 100 µM -0.043557401052076 0.472303375296063 no 1805 0.482628604241485 2499 3515 A coloring agent. SGTC_3089 9117425 49.47 µM -0.044035430539566 0.472121534782284 no 1806 0.482438080881018 2534 9401657 SGTC_740 k014-0057 261 µM -0.0456995957257536 0.47148853854108 no 1807 0.481774843019212 2546 4012779 SGTC_2508 celastrol 40.54 µM -0.0460409511523047 0.471358706492184 no 1808 0.481638805100353 2469 122724 Celastrol is a natural product and antioxidant. SGTC_569 4130-2812 160 µM -0.0467543146972508 0.471087393709645 no 1809 0.481354520387324 2484 743552 SGTC_3287 9117173 37.0625 µM -0.0474163685989365 0.470835607470972 no 1810 0.481090691718964 2485 2789709 SGTC_1836 st055642 81 µM -0.0485527298088789 0.470403464281595 no 1811 0.480637870824939 2484 8571 SGTC_1214 0358-0031 63.7 µM -0.0492020072864565 0.47015656822853 no 1812 0.48037915581132 2615 4301366 SGTC_823 0417-1665 178 µM -0.0504185202020062 0.46969400461496 no 1813 0.479894439083846 2557 3429856 SGTC_3170 9103054 49.47 µM -0.0510954356883303 0.469436633752719 no 1814 0.479624736518512 2532 16432970 SGTC_2190 6049624 200 µM -0.0517051177894339 0.469204836704995 no 1815 0.479381829645145 2481 2265554 SGTC_1382 3002-2117 298 µM -0.0520954891231339 0.469056425616815 no 1816 0.479226303622855 2488 1497314 SGTC_156 3474-0145 5.642 µM -0.0541036477955127 0.468293033716992 no 1817 0.478426292992956 2478 2265471 SGTC_875 0709-0210 25.7 µM -0.0544464906162383 0.468162715233566 no 1818 0.478289719802619 2498 6251364 SGTC_1788 fluconazole 20 µM -0.0547117494768335 0.468061889642331 no 1819 0.478184054327853 2598 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2027 5150920 200 µM -0.0547776419722181 0.468036844048784 no 1820 0.478157806387271 2555 786715 SGTC_2708 st078559 56 µM -0.0549055406640055 0.467988230396651 no 1821 0.478106858864068 2500 17250902 SGTC_805 3852-0218 479 µM -0.0550329312190828 0.467939810359281 no 1822 0.478056114109106 2517 6615355 SGTC_2236 dapsone 200 µM -0.0557677566495994 0.467660518912093 no 1823 0.477763410709927 2497 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_710 3448-4187 58 µM -0.0570528796994788 0.467172109443122 no 1824 0.477251535897785 2524 3946412 SGTC_125 0133-0007 11.75 µM -0.0582100168412452 0.466732383127088 no 1825 0.476790670983878 2577 26541 SGTC_2399 5884133 200 µM -0.0602213549965923 0.465968146877449 no 1826 0.475989668876046 2542 722445 SGTC_2807 7945238 51.95 µM -0.0607929297020501 0.465750991794047 no 1827 0.475762060594272 2567 17148797 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0614419656654583 0.46550441966883 no 1828 0.475503615852332 2592 616764 SGTC_2471 5466956 24.79 µM -0.0618564034979101 0.465346979510922 no 1829 0.475338592972491 2569 724419 SGTC_1782 st039423 80.636 µM -0.0618570978294816 0.465346715746901 no 1830 0.475338316503697 2553 2068169 SGTC_2576 guaiol 23.12 µM -0.0619356412368006 0.465316878623707 no 1831 0.475307042183566 2618 227829 SGTC_201 4262-0159 12.803 µM -0.0622002893652243 0.465216345348327 no 1832 0.475201666028882 2539 1341029 SGTC_938 3126-1755 342 µM -0.0623395612532141 0.465163440295485 no 1833 0.475146212200942 2519 1777771 SGTC_3193 9111931 49.47 µM -0.0623693508385314 0.465152124239682 no 1834 0.475134350956994 2538 17087244 SGTC_1625 st003711 30.1 µM -0.0624430635084806 0.465124123410926 no 1835 0.475105001064126 2569 24207034 YER133W GLC7 SGTC_3099 9120367 49.47 µM -0.0627029811312869 0.465025391304118 no 1836 0.47500151173389 2525 24824940 SGTC_1891 st059073 26.2 µM -0.0627230586324698 0.465017764769582 no 1837 0.474993517705199 2540 688754 SGTC_2331 7980721 200 µM -0.0644941412718997 0.464345061468247 no 1838 0.4742883859946 2597 2981221 SGTC_2074 5212007 75.395 µM -0.0652290592090878 0.464065950307252 no 1839 0.473995812244002 2509 758611 SGTC_196 k015-0023 18.111 µM -0.0657114222364415 0.463882765437476 no 1840 0.473803789220238 2519 5211998 SGTC_1999 st074831 12.5 µM -0.0664963602317079 0.463584689397062 no 1841 0.473491327706124 2547 17112523 SGTC_2295 7971645 200 µM -0.0665241826820706 0.463574124343239 no 1842 0.473480252677278 2592 2978226 YKL099C UTP11 SGTC_987 1497-1013 404 µM -0.0668228917084945 0.463460696811576 no 1843 0.473361349595004 2510 1676435 SGTC_2739 tacrine 100.86 µM -0.0669903912523644 0.463397094208185 no 1844 0.473294676343578 2598 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2066 5222451 176 µM -0.0674966157297377 0.463204877320249 no 1845 0.473093178069926 2524 2281147 SGTC_2188 6126565 140.678 µM -0.067900644161059 0.463051471130087 no 1846 0.472932362986006 2530 874518 SGTC_887 0885-0007 9.62 µM -0.0687353613437739 0.462734553478694 no 1847 0.472600135236143 2661 5719458 SGTC_360 0957-0399 1.01 µM -0.0688272340780065 0.462699673535303 no 1848 0.47256356991327 2601 6752301 YPR165W RHO1 SGTC_1033 k072-0102 21.3 µM -0.0693731334633998 0.462492426025353 no 1849 0.472346306887542 2513 5965931 SGTC_2482 5981709 142.65 µM -0.0717313436965977 0.4615972630029 no 1850 0.47140785587074 2597 877755 SGTC_1187 1391-0724 117 µM -0.0719465929722455 0.461515565237014 no 1851 0.471322205134185 2574 6997986 SGTC_2707 st078556 66.6 µM -0.0720713312274959 0.461468221631282 no 1852 0.471272570621861 2560 17250899 SGTC_1735 st034310 56.75 µM -0.0725541847206179 0.461284962834869 no 1853 0.471080442938132 2755 871153 SGTC_2692 st077426 47.7 µM -0.0729350739294451 0.461140408639125 no 1854 0.470928891648574 2547 25238571 SGTC_2152 5568786 200 µM -0.0731168517064929 0.461071422564316 no 1855 0.470856565914128 2525 5399883 SGTC_88 0180-0332 8.668 µM -0.0734074270450265 0.460961149405816 no 1856 0.470740953807851 2515 3101745 SGTC_1759 st043059 70 µM -0.0746547567018997 0.460487822788914 no 1857 0.470244703043751 2559 669426 SGTC_1219 1469-0211 33.1 µM -0.078266075364283 0.459117746686916 no 1858 0.468808201297528 2539 6822282 SGTC_671 0560-0003 407 µM -0.0789111454865737 0.45887306810889 no 1859 0.468551649036043 2641 3238678 SGTC_2268 7933382 153.85 µM -0.078974592254075 0.458849003247677 no 1860 0.468526416185826 2520 935025 YOR257W CDC31 SGTC_794 k038-0031 316 µM -0.0795178682850976 0.458642949093961 no 1861 0.468310359888982 2532 6624242 SGTC_2298 7976326 193.81 µM -0.0798583056759442 0.458513833396553 no 1862 0.46817497556192 2593 2235818 SGTC_3002 9075603 71.4286 µM -0.079976692931684 0.458468934379724 no 1863 0.468127896463032 2544 20105405 SGTC_2294 7971431 200 µM -0.080269065196214 0.458358052864263 no 1864 0.468011630599667 2625 5741572 SGTC_3001 9076041 71.4286 µM -0.0812325150619802 0.45799268967498 no 1865 0.467628520836371 2555 16004211 SGTC_2745 rifampicin 24.3 µM -0.0832171312179416 0.457240188047468 no 1866 0.466839445621923 2619 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2308 7584454 197.62 µM -0.0832610728990985 0.457223528521714 no 1867 0.466821976053514 2589 893577 SGTC_2585 alliin 100 µM -0.0850581915230719 0.456542255100604 no 1868 0.466107564066779 2627 87310 A garlic compound which reacts with lipids. SGTC_3336 9143619 71.43 µM -0.0857119324395526 0.456294458679088 no 1869 0.465847708161866 2537 45595730 SGTC_3192 9110362 49.47 µM -0.0879683966986593 0.455439291139369 no 1870 0.464950897258996 2554 16649480 SGTC_1265 0819-1001 68.8 µM -0.0895851391879503 0.454826695667343 no 1871 0.464308447064009 2538 3106768 SGTC_867 0518-0118 155 µM -0.0899769624271191 0.454678247111771 no 1872 0.464152760939269 2587 6848158 SGTC_1129 3453-1384 223 µM -0.0905900910743469 0.454445966141332 no 1873 0.463909152867032 2782 1084452 SGTC_3007 9078383 71.4286 µM -0.0906900797029378 0.454408087384112 no 1874 0.463869426698828 2596 6496995 SGTC_1808 st050063 61.5 µM -0.0921959130361562 0.453837681897491 no 1875 0.463271192570641 2562 4011993 SGTC_1995 st072814 61.1 µM -0.0952046415344793 0.452698270203417 no 1876 0.462076141662241 2587 5769371 SGTC_2791 5663188 71.43 µM -0.0961695932011566 0.452332923033001 no 1877 0.461692939982373 2668 54690634 SGTC_1236 0330-0013 258 µM -0.0967735706211155 0.452104267389033 no 1878 0.461453106494567 2615 4617066 SGTC_350 k064-0020 19.8 µM -0.0968216202138255 0.452086077306444 no 1879 0.461434027075116 2637 2790705 SGTC_374 0880-0231 82.3 µM -0.0971871557838783 0.451947700194872 no 1880 0.461288883978503 2629 6833587 SGTC_2255 7941087 197.44 µM -0.0974732565967038 0.451839397969288 no 1881 0.461175285612773 2571 935561 SGTC_834 0312-0008 75.7 µM -0.0979399455401661 0.451662742582703 no 1882 0.46098999024589 2568 6385573 YIL048W NEO1 SGTC_2582 agaric acid 100 µM -0.0983091915028662 0.45152297898887 no 1883 0.460843389887627 2590 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3125 9127534 49.47 µM -0.0984112781869258 0.45148433913344 no 1884 0.460802859727374 2569 1639235 SGTC_258 haloperidol 50.781 µM -0.0984908235943239 0.451454231479875 no 1885 0.460771279121859 2583 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1469 k284-2957 126 µM -0.0986351492922869 0.451399605429999 no 1886 0.460713980494289 2618 23884841 SGTC_2276 7947513 42.08 µM -0.0988974136052632 0.451300342973192 no 1887 0.460609861242071 2656 2105100 SGTC_3224 9130643 49.47 µM -0.100731416127794 0.450606290529831 no 1888 0.459881835871281 2691 17644395 SGTC_2499 avocadenofuran 51.48 µM -0.10205236681643 0.45010648876279 no 1889 0.459357554655332 2589 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2850 9015429 58.44 µM -0.102417711105373 0.449968269133698 no 1890 0.459212563081958 2634 6457570 SGTC_3355 9151058 44.0485 µM -0.106259721870279 0.448515103197161 no 1891 0.457688143949406 2588 17015728 SGTC_802 4112-3352 742 µM -0.106776976783489 0.448319513885531 no 1892 0.457482956450138 2744 704594 SGTC_631 k072-0230 41.5 µM -0.106976193331955 0.448244187591406 no 1893 0.457403933163289 2685 5773147 SGTC_779 1360-0071 233 µM -0.106979977982788 0.448242756585159 no 1894 0.457402431921021 2780 7566 SGTC_1074 carmofur 3.8 µM -0.107474131096747 0.448055919197845 no 1895 0.457206423415741 2584 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2566 crystal violet carbinol 226 nM -0.108014974596271 0.447851441564384 no 1896 0.45699190684947 2761 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3084 9116877 49.47 µM -0.108016932380142 0.447850701406801 no 1897 0.456991130349831 2582 27241325 SGTC_3137 9097352 49.47 µM -0.108383984622425 0.447711937257256 no 1898 0.456845552356577 2801 44120435 SGTC_746 1095-0025 46.6 µM -0.108695839184732 0.447594045625376 no 1899 0.456721871075939 2678 6749286 SGTC_701 4424-0219 185 µM -0.109072685586994 0.447451591045566 no 1900 0.456572419676438 2650 2911779 SGTC_363 0455-0021 3.06 µM -0.109781737799229 0.447183575206006 no 1901 0.456291237308607 2616 4597466 SGTC_1798 st045719 60.953 µM -0.110497644968972 0.446912992718367 no 1902 0.456007358738339 2598 3980186 SGTC_1467 k284-1082 293 µM -0.111732848499411 0.44644619644258 no 1903 0.455517616532347 2638 3334705 SGTC_1575 cyproterone acetate 48 µM -0.113722654098929 0.445694384501779 no 1904 0.454728826824592 2636 9880 An androgen receptor antagonist and liver toxin. SGTC_2006 4011487 200 µM -0.114248928745172 0.445495573711242 no 1905 0.454520233134619 2694 45595294 SGTC_286 k060-0067 22.9 µM -0.115014593845518 0.445206352869386 no 1906 0.454216777296676 2632 5985051 SGTC_229 benomyl 22.8748 µM -0.115508382453608 0.445019845582035 no 1907 0.454021088356583 2676 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.11586696653798 0.444884413580405 no 1908 0.453878988102949 2707 7104 SGTC_3048 9093155 49.47 µM -0.11710034067654 0.444418635294216 no 1909 0.453390269886829 2608 25236002 SGTC_1908 st060353 56.5 µM -0.118982814151945 0.443707875687332 no 1910 0.452644485685734 2729 4227716 SGTC_1709 st033179 39.1045 µM -0.119296391915226 0.44358949664365 no 1911 0.4525202709611 2608 573381 SGTC_858 0438-0351 2.77 µM -0.119452524851224 0.44353055662499 no 1912 0.452458425164623 2630 2799119 SGTC_99 0109-0120 622.8 µM -0.12287674947254 0.442238231830059 no 1913 0.451102348657767 2635 759414 SGTC_3018 9082602 49.47 µM -0.123492221318809 0.442006013475616 no 1914 0.450858666816338 2625 17332089 SGTC_618 k072-0232 33.2 µM -0.124445022643676 0.441646559589804 no 1915 0.450481463731692 2701 5872756 YGL099W LSG1 SGTC_3083 9117465 49.47 µM -0.125890772437148 0.441101227804629 no 1916 0.44990919354514 2714 16420915 SGTC_2919 7978188 46.38 µM -0.126552988320809 0.44085147950284 no 1917 0.449647103775236 2677 2980291 SGTC_781 4335-2806 94.4 µM -0.127235932760399 0.440593938267411 no 1918 0.449376833127953 2803 845254 SGTC_1901 st060216 58.6 µM -0.127502914112804 0.440493265295993 no 1919 0.449271183439664 2639 688792 SGTC_52 0329-0193 875 nM -0.130062917718508 0.439528138750965 no 1920 0.44825832411509 2858 3739292 SGTC_2601 securinine 100 µM -0.130729308435764 0.439276966807908 no 1921 0.447994723262634 2668 442872 A GABA receptor antagonist. SGTC_45 0kpi-0036 14.9 µM -0.130996947561538 0.439176096768439 no 1922 0.44788886104529 2735 2795021 SGTC_1089 terbinafine 2.25 µM -0.131401899932079 0.439023482492465 no 1923 0.447728692883856 2751 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2797 7859098 81.82 µM -0.131557014727363 0.43896502682673 no 1924 0.447667343599909 2671 972681 SGTC_1873 rapamycin 2 nM -0.131856903378802 0.438852016297524 no 1925 0.447548738516733 2654 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2349 9023730 187.07 µM -0.131938138812637 0.438821404261596 no 1926 0.447516610947449 2728 4126287 SGTC_3144 9087057 49.47 µM -0.132351980507225 0.438665461535155 no 1927 0.447352947229581 2605 17249618 SGTC_476 mead acid 10 µM -0.133143736055979 0.438367140868271 no 1928 0.447039853332005 2642 5312531 An omega 9 fatty acid. SGTC_1446 4239-0190 62 µM -0.134794989196704 0.43774508829109 no 1929 0.446386983861003 2662 1340085 SGTC_460 trequinsin 123 µM -0.135339353859839 0.437540051348491 no 1930 0.446171785708509 2642 5537 A vasodilator. SGTC_1477 0139-0234 16 µM -0.136653407833244 0.437045177320493 no 1931 0.445652379546831 2624 620880 SGTC_1290 0986-0249 10.2 µM -0.137514480630842 0.43672094981761 no 1932 0.445312073795031 2689 53329 SGTC_3165 9101544 49.47 µM -0.138927614529871 0.43618894198535 no 1933 0.444753674663254 2748 5002184 SGTC_1277 0873-0036 22 µM -0.139917882612622 0.435816200761674 no 1934 0.44436243599737 2725 5965735 SGTC_1761 st044296 37 µM -0.140153580670433 0.435727491371599 no 1935 0.444269323535381 2636 1826700 SGTC_699 0375-0592 111 µM -0.140254601713489 0.4356894711948 no 1936 0.44422941613759 2669 762578 SGTC_2337 9009472 200 µM -0.141130375862245 0.435359890677973 no 1937 0.443883473669543 2738 5742383 SGTC_2015 5119600 184 µM -0.141173916595874 0.435343506141917 no 1938 0.443866275612622 2792 2828786 SGTC_392 N-ethylmaleimide 8.33 µM -0.141552269346637 0.435201135305001 no 1939 0.443716835360371 2690 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_43 0570-0105 72.5 µM -0.14250861369866 0.434841308764787 no 1940 0.44333913803235 2663 1114046 YDL195W SEC31 SGTC_2512 diallyl trisulfide 49.23 µM -0.142593882589986 0.434809228783775 no 1941 0.443305464547496 2638 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1283 0922-0125 16.4 µM -0.143261319850771 0.434558139451467 no 1942 0.443041901477664 2763 3360884 SGTC_922 1866-0035 480 µM -0.143323026260841 0.434534926883632 no 1943 0.44301753561797 2670 3156169 SGTC_407 eburnamonine 100 µM -0.143790134887007 0.434359218418212 no 1944 0.442833096569776 2651 3195 SGTC_2162 5663267 200 µM -0.144337302504734 0.434153411303517 no 1945 0.442617061778922 2689 6456493 SGTC_2462 5162487 171.77 µM -0.145218713429609 0.433821922220322 no 1946 0.442269095684031 2641 2259986 SGTC_2402 5553605 200 µM -0.145227550727548 0.433818598843735 no 1947 0.442265607093642 2819 6758546 SGTC_1747 st037496 66.6 µM -0.145592552265898 0.433681339533065 no 1948 0.442121523882469 2679 723305 SGTC_1755 st041960 45.185 µM -0.145628161325272 0.433667949127148 no 1949 0.442107467727709 2782 2257073 SGTC_3070 9117005 49.47 µM -0.145695791443052 0.433642517754319 no 1950 0.442080771929728 2657 8779016 SGTC_646 4092-0839 27.3 µM -0.14571400383562 0.433635669282282 no 1951 0.442073582953445 2774 877796 SGTC_584 0986-0246 15.4 µM -0.147170164739679 0.433088168469263 no 1952 0.441498854616312 2654 53315 YDR232W HEM1 SGTC_1035 k081-0041 55.2 µM -0.148230715369927 0.432689493612324 no 1953 0.441080346105711 2643 731709 SGTC_373 0844-0104 25.9 µM -0.149528461357049 0.43220174716273 no 1954 0.440568326449785 2756 5375804 SGTC_2803 7707263 71.43 µM -0.150715536583475 0.431755685798606 no 1955 0.440100058408398 2702 2199229 SGTC_2782 7736369 71.43 µM -0.151363013731428 0.431512423156415 no 1956 0.439844682012646 2716 2950836 YOL077C BRX1 SGTC_2050 5263056 171 µM -0.151877928165665 0.431318983983221 no 1957 0.439641608547237 2771 763468 YGL055W OLE1 SGTC_2297 7971671 152.32 µM -0.152113437303727 0.431230515172435 no 1958 0.439548733051912 2813 909016 SGTC_1202 1988-0068 29.6 µM -0.153141108366251 0.430844511827836 no 1959 0.43914349920578 2692 2850480 SGTC_3035 9091303 49.47 µM -0.15338010421171 0.430754752094699 no 1960 0.439049266885405 2676 25237002 SGTC_2403 6032726 181.2 µM -0.153385906018953 0.430752573152865 no 1961 0.43904697936656 2748 2881040 SGTC_786 4544-0069 423 µM -0.153747768915122 0.430616675150095 no 1962 0.438904309194816 2807 748821 YLR208W SEC13 SGTC_988 1497-1057 103 µM -0.153820647409772 0.430589306545958 no 1963 0.438875576654978 2675 3533044 SGTC_1603 st002045 67.8 µM -0.154295467710261 0.4304110019083 no 1964 0.438688385384149 2697 5887985 SGTC_403 arphamenine a 50 µM -0.154722721478269 0.430250571592568 no 1965 0.438519958274859 2682 5487158 An arginine aminopeptidase inhibitor. SGTC_1084 voriconazole 435 nM -0.155286906942281 0.430038742182138 no 1966 0.438297568576276 2696 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2768 sulfasalazine 50.2 µM -0.156415254858512 0.429615152465171 no 1967 0.437852856765472 2720 5384001 An antioxidant and salicylic acid derivative. SGTC_44 0929-0055 61.211 µM -0.156916484841861 0.429427013175208 no 1968 0.437655333889854 2691 1379590 SGTC_179 1273-0063 6.77 µM -0.157894017544746 0.42906013732432 no 1969 0.437270156119709 2701 3108139 SGTC_1777 st045864 34.765 µM -0.158352034004987 0.428888261141334 no 1970 0.437089704061773 2685 4691462 SGTC_2265 7929201 200 µM -0.158926091753523 0.428672858114501 no 1971 0.436863551850057 2653 1265108 SGTC_16 erodoxin 22.806 µM -0.161386951519956 0.427749714056071 no 1972 0.435894321569156 2700 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2867 9039098 71.43 µM -0.162769635219772 0.427231200097174 no 1973 0.435349908486238 2679 6463460 SGTC_2340 7987427 183.45 µM -0.163733944038888 0.42686965334975 no 1974 0.434970297331897 2810 2239331 SGTC_1548 st061468 90.8 µM -0.163837173644069 0.426830953275368 no 1975 0.434929663366803 2796 390799 SGTC_819 1013-0258 27.7 µM -0.163938187524678 0.426793084542804 no 1976 0.434889902236098 2704 5753198 SGTC_1260 0700-1617 7.75 µM -0.165810518656084 0.426091295540991 no 1977 0.434153034011572 2791 2853078 SGTC_1474 0330-0125 5.35 µM -0.166378839238392 0.425878323250818 no 1978 0.43392941284544 2735 X1474 SGTC_2085 5307070 144.047 µM -0.166462374629198 0.42584702104362 no 1979 0.433896545358135 2678 2840351 SGTC_1776 st049249 45.9 µM -0.166721499651441 0.425749925230083 no 1980 0.433794594013722 2737 1822314 SGTC_1900 st060200 72.8 µM -0.167736973073429 0.425369464247479 no 1981 0.433395103977362 2676 688945 SGTC_2635 hydroquinidine 100 µM -0.167849031962667 0.425327484105201 no 1982 0.433351023863394 2705 442912 An experimental heart treatment. SGTC_906 1165-0455 526 µM -0.170068734854277 0.42449610138234 no 1983 0.432478040631222 2692 3252859 SGTC_1658 st012944 20 µM -0.171073248123303 0.424119974250528 no 1984 0.432083085333506 2767 24207260 SGTC_206 4546-0025 72.014 µM -0.171244085621007 0.424056013203191 no 1985 0.432015922056849 2729 6620745 YIL048W NEO1 SGTC_761 k216-0224 480 µM -0.17145651057438 0.423976484727268 no 1986 0.431932411774345 2719 1340404 SGTC_309 k408-0051 1.48 µM -0.174725887551678 0.422752875135095 no 1987 0.430647512675312 2744 3640463 SGTC_1208 2323-2347 50.3 µM -0.176125075835905 0.422229436479749 no 1988 0.430097840591926 2837 5412760 SGTC_2125 5246583 200 µM -0.17652199367496 0.422080973822887 no 1989 0.429941935759783 2766 835267 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.177972514341943 0.421538517184373 no 1990 0.429372280745787 2664 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1298 1079-1278 263 µM -0.178950988767045 0.421172677461294 no 1991 0.428988092836713 2754 2840950 SGTC_1563 conessine 56.1 µM -0.178955390846938 0.421171031730525 no 1992 0.428986364557089 2829 441082 An anti-amoebic, histamine inhibitor. SGTC_629 3448-6466 76.7 µM -0.18096612705464 0.420419456407352 no 1993 0.428197081845588 2758 573744 SGTC_216 k038-0035 28.382 µM -0.181328767581251 0.420283939001143 no 1994 0.42805476351384 2715 4444231 YPR107C YTH1 SGTC_764 1951-2361 146 µM -0.182744598309907 0.419754938969616 no 1995 0.427499210280397 2749 5438930 SGTC_3034 9090421 49.47 µM -0.186161614016026 0.418478830589492 no 1996 0.426159012644922 2714 17173761 SGTC_1032 k061-1018 98.7 µM -0.186246957628425 0.418446969341918 no 1997 0.42612555062524 2945 4005393 SGTC_2197 6588183 93.1375 µM -0.186297476292127 0.418428109510564 no 1998 0.426105743224481 2750 884136 SGTC_2245 6637752 200 µM -0.186629463814815 0.418304175256485 no 1999 0.42597558191343 2908 681890 SGTC_2475 5812728 15.03 µM -0.18709356582841 0.418130934941471 no 2000 0.425793636406418 2716 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2806 7952793 58.44 µM -0.187714982397617 0.417898997018229 no 2001 0.42555004240003 2875 2972490 SGTC_85 0868-0259 160.055 µM -0.188324676257032 0.417671462236203 no 2002 0.425311071285452 2801 83173 SGTC_431 k089-0097 107 µM -0.188487998846794 0.417610515717335 no 2003 0.425247061221835 2817 5499420 SGTC_2965 9082772 38.63 µM -0.188994226194946 0.417421621210549 no 2004 0.425048671036262 2856 16459634 SGTC_1739 st037196 92.5 µM -0.189401262409559 0.417269752865325 no 2005 0.424889167558236 2870 612214 SGTC_1737 st035557 69.7 µM -0.190069821129745 0.417020335253171 no 2006 0.424627209111132 2677 5716916 SGTC_1357 1503-1303 39.5 µM -0.190720665945619 0.416777558201415 no 2007 0.424372223399411 2767 292895 SGTC_2328 6201408 200 µM -0.191667130678801 0.416424566155828 no 2008 0.424001477252909 2845 2890418 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.192556096935201 0.41609308002237 no 2009 0.423653315465881 2823 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1250 0485-0349 40.2 µM -0.192746644401136 0.41602203464284 no 2010 0.423578695693414 2767 6842794 YDL195W SEC31 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.194356716430296 0.415421831122255 no 2011 0.422948289456599 3166 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_825 1988-2224 89.6 µM -0.195030287858233 0.415170795254572 no 2012 0.422684618298414 2745 1180859 SGTC_1240 0356-0016 42.1 µM -0.196160734070506 0.414749562880131 no 2013 0.422242180305549 2826 4305613 SGTC_1013 4112-3890 241 µM -0.198764816017763 0.413779590857226 no 2014 0.421223359775518 2746 705171 SGTC_2977 9011197 71.43 µM -0.199195700882642 0.41361914481339 no 2015 0.42105483111839 2986 2704722 SGTC_1139 k015-0024 46.9 µM -0.199622169424742 0.413460357449476 no 2016 0.420888044025904 2759 2766652 SGTC_2608 thymoquinone 42.66 µM -0.200624920849627 0.41308705803431 no 2017 0.420495935114842 2732 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_480 am 92016 50 µM -0.20071825127759 0.413052317428856 no 2018 0.420459443842839 2819 2129 K+ channel blocker. SGTC_3047 9092122 49.47 µM -0.201899104591993 0.412612824506861 no 2019 0.419997801046906 2826 17173831 SGTC_1162 k048-0130 20.1 µM -0.201909088426008 0.412609109164886 no 2020 0.419993898435107 2764 6797406 SGTC_2956 9076196 2.52 µM -0.20356787163481 0.411991925528863 no 2021 0.419345601051083 2867 16423868 SGTC_3147 9097027 49.47 µM -0.20366252235217 0.411956715375794 no 2022 0.41930861557309 2797 25236841 SGTC_1898 st060199 18.6 µM -0.203702402354843 0.411941880190699 no 2023 0.419293032376281 2757 688866 SGTC_905 2-aminofluorene 215 µM -0.204248680608068 0.411738679767885 no 2024 0.419079585727818 2771 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1366 1683-0113 21.9 µM -0.205670047873124 0.411210081435163 no 2025 0.418524328341312 2767 708623 SGTC_692 k241-0027 77.8 µM -0.205691774576388 0.411202002646976 no 2026 0.418515842057275 2938 3600480 SGTC_2154 5570129 200 µM -0.205792188132258 0.411164665679219 no 2027 0.418476621783482 2749 673366 SGTC_27 0485-0001 32.618 µM -0.206014365577201 0.411082055868208 no 2028 0.418389844944916 2734 2054479 SGTC_3133 9127736 49.47 µM -0.206828040455141 0.410779549720778 no 2029 0.418072078247619 2762 27243420 SGTC_2072 5231554 129 µM -0.207606906690864 0.410490034348787 no 2030 0.417767955553139 2875 789545 SGTC_2048 5246248 200 µM -0.208863241934563 0.410023139972024 no 2031 0.417277499977196 2839 677046 SGTC_2433 5607874 27.82 µM -0.209981531268518 0.409607655130095 no 2032 0.416841043803984 2773 2252428 SGTC_1337 1486-1011 40.3 µM -0.210100746591888 0.409563368314005 no 2033 0.416794521394339 2778 X1337 SGTC_117 lucigenin 22.078 µM -0.210814328338987 0.409298306874609 no 2034 0.416516078703203 2837 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.21305767574666 0.408465281367502 no 2035 0.41564098826423 2830 4213774 SGTC_2200 6600604 21.907 µM -0.213525654796401 0.408291558009044 no 2036 0.415458490427347 2780 2904777 SGTC_2158 5657123 3.6195 µM -0.216675160674762 0.407122867689345 no 2037 0.414230753526768 2763 2858827 SGTC_2064 5220758 200 µM -0.217571573268467 0.406790385592308 no 2038 0.413881467569789 2944 788518 SGTC_1456 k015-0012 13 µM -0.218782851081918 0.406341225795207 no 2039 0.413409603061268 2798 2989616 SGTC_2277 7947813 106.88 µM -0.219719205215998 0.405994096188447 no 2040 0.413044923272079 3029 1246798 SGTC_2839 9003951 25.97 µM -0.222051444288063 0.405129799350633 no 2041 0.412136918033339 2785 2990634 SGTC_3298 9116858 71.43 µM -0.222524206167249 0.404954656317065 no 2042 0.41195291589952 2943 2506942 SGTC_1971 st069429 63.5 µM -0.223270429396608 0.404678243421407 no 2043 0.411662520155253 2946 1246522 YGL099W LSG1 SGTC_612 0302-0167 22.4 µM -0.224775595964474 0.404120850753096 no 2044 0.411076925948702 2872 235821 SGTC_2699 st077704 54.6 µM -0.225535475830144 0.403839526199089 no 2045 0.410781365232364 2857 645852 SGTC_2821 7996764 71.43 µM -0.226003229472586 0.403666378039883 no 2046 0.410599454277179 3027 2987135 SGTC_2059 5238311 157 µM -0.226408922915708 0.403516217962939 no 2047 0.410441694311386 2806 703021 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.227201994899149 0.403222717833146 no 2048 0.410133338275841 2929 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2831 7999036 19.48 µM -0.227515890295445 0.403106566452486 no 2049 0.410011307262993 3100 2988270 SGTC_2563 tomatine 8.54 µM -0.22830587823134 0.40281428338987 no 2050 0.409704227529868 2848 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_406 estrone 100 µM -0.228311856453601 0.402812071748853 no 2051 0.409701903919335 3009 5870 A steroid. SGTC_1160 4092-0570 10.5 µM -0.230155299943917 0.40213023920209 no 2052 0.408985547468328 2814 4994975 SGTC_3208 9114115 49.47 µM -0.230539041191296 0.401988342589783 no 2053 0.408836464938809 2889 650895 SGTC_2906 7926292 26.41 µM -0.23176627974846 0.401534631436365 no 2054 0.408359774416516 2951 2966319 SGTC_2545 solidagenone 89.61 µM -0.233210135910769 0.401001006517014 no 2055 0.407799117755824 2754 6708572 An anti ulcer agent SGTC_2275 7947463 200 µM -0.234059336807032 0.400687242339015 no 2056 0.407469456830033 2807 1225414 SGTC_3290 9121031 71.43 µM -0.235350164727751 0.400210427828068 no 2057 0.406968481262912 2866 17014854 SGTC_3230 9131665 49.47 µM -0.235430869096107 0.400180621649513 no 2058 0.406937164615466 2812 15943720 SGTC_3196 9111891 49.47 µM -0.238070150369183 0.39920618924838 no 2059 0.405913342879043 2784 18891510 SGTC_2549 cedrol 20.94 µM -0.238204836879646 0.399156479273418 no 2060 0.405861112898678 3007 6708665 A sedative which affects the nervous system. SGTC_2645 abamectin 100 µM -0.239092312467623 0.398828971512073 no 2061 0.405517001348282 2951 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2378 9074213 121.43 µM -0.239711742799346 0.398600423479188 no 2062 0.405276865446099 2827 657714 SGTC_3061 glucosamine 200 µM -0.242788177805438 0.397465843668119 no 2063 0.404084747174606 2876 91431 and experimental redox chemotherapeutic SGTC_635 k038-0028 24.7 µM -0.243099039636148 0.397351246843404 no 2064 0.403964337581855 2882 4035102 SGTC_2706 st078239 82.5 µM -0.24339709898343 0.397241377875735 no 2065 0.403848895462835 2832 15434492 SGTC_859 0439-0102 54.6 µM -0.243577378080261 0.397174928361146 no 2066 0.403779075174186 2938 610143 SGTC_1758 st042942 75.2445 µM -0.243832457307401 0.397080913182564 no 2067 0.403680290782601 2829 669317 SGTC_151 3013-0144 2.285 µM -0.243926597175666 0.397046217330185 no 2068 0.403643834839574 3049 906558 YHR107C CDC12 SGTC_2332 7982454 138.89 µM -0.244046065435991 0.397002187709629 no 2069 0.403597571606969 2904 2981748 SGTC_945 3381-0768 11.3 µM -0.247253249424629 0.395820683373247 no 2070 0.402356118595582 2982 1126236 YIL048W NEO1 SGTC_1082 camptothecin 424.86 nM -0.2474541351931 0.39574671017265 no 2071 0.402278391340345 2719 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2921 7974240 10.71 µM -0.248253690575986 0.395452323018437 no 2072 0.401969063569274 2970 2979074 YDR527W RBA50 SGTC_1216 1165-0504 9.65 µM -0.250177571378881 0.394744216823614 no 2073 0.401225014650777 2964 6304004 SGTC_1145 3546-0597 10.2 µM -0.250196319445537 0.394737318090937 no 2074 0.401217765710074 2889 875334 SGTC_2202 7226349 200 µM -0.251703557229629 0.394182807444696 no 2075 0.400635103618868 2838 844334 SGTC_674 0498-0004 451 µM -0.252559892057441 0.393867858514866 no 2076 0.400304163420807 2906 4231473 SGTC_384 k007-0144 5.16 µM -0.252592047055764 0.393856033670997 no 2077 0.400291738153766 2913 6824886 SGTC_1990 st072050 59.8 µM -0.255462814795603 0.392800718459671 no 2078 0.399182830231837 2824 17233948 SGTC_2320 7373003 200 µM -0.256197856832943 0.392530637958286 no 2079 0.39889903170989 2908 5415828 SGTC_1977 st070720 65.3 µM -0.256210681997523 0.392525925997129 no 2080 0.398894080408858 2972 682188 SGTC_2080 5212524 12.4 µM -0.257356646898596 0.392104962549546 no 2081 0.398451733356642 2905 260183 SGTC_2653 dihydrofissinolide 100 µM -0.257415634064138 0.392083297374666 no 2082 0.398428967599186 2904 6857746 SGTC_1101 ebselen 5.29 µM -0.258209230283627 0.3917918529492 no 2083 0.398122717339621 3020 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1813 st051246 8.6015 µM -0.25840304643908 0.391720684109141 no 2084 0.39804793285099 2944 5291959 SGTC_1607 st000305 50.6 µM -0.258809504749142 0.391571445336161 no 2085 0.397891111977165 3015 5457690 SGTC_601 0986-0029 62.9 µM -0.259092902083162 0.391467400143043 no 2086 0.39778178058982 2875 24747981 SGTC_816 0325-0417 81.3 µM -0.260151524413652 0.391078811140521 no 2087 0.397373447503246 2915 68101 SGTC_1521 st012942 49.4 µM -0.261080484640078 0.390737906806862 no 2088 0.397015220451919 3084 24207259 SGTC_3131 9127911 49.47 µM -0.262011505883389 0.390396330370396 no 2089 0.396656285789145 3107 45595681 SGTC_2557 derrustone 83.84 µM -0.262096384949493 0.390365193835259 no 2090 0.396623566891419 2991 629853 An antioxidant. SGTC_3206 9114350 49.47 µM -0.263348865471117 0.389905823124732 no 2091 0.396140849631874 2989 17087243 SGTC_416 estradiol valerate 100 µM -0.263439362342749 0.389872637647954 no 2092 0.396105977481769 2922 13791 A steroid. SGTC_262 fenpropimorph 62.5 µM -0.264023513683657 0.389658446907248 no 2093 0.395880900066134 2852 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1668 st014914 51.6 µM -0.264448949490238 0.389502473468309 no 2094 0.395716998648103 2920 2839556 SGTC_1289 0976-0073 69.1 µM -0.265818904482726 0.389000341088079 no 2095 0.395189341590504 2981 3391136 SGTC_3021 9087658 49.47 µM -0.266173737469548 0.38887031362105 no 2096 0.39505270405962 2924 25237042 SGTC_135 0933-0004 26.348 µM -0.26638459993047 0.388793049610056 no 2097 0.394971512179455 2996 21230617 YGL099W LSG1 SGTC_3111 9122088 49.47 µM -0.266797828088826 0.388641647722465 no 2098 0.394812413298066 2922 16876704 SGTC_159 3970-0959 50 µM -0.268167655101999 0.38813988046827 no 2099 0.394285135453568 2961 6615653 SGTC_1165 k072-0275 30.3 µM -0.269409684428234 0.387685086799265 no 2100 0.393807217244561 2967 6153523 YGL055W OLE1 SGTC_900 1112-0045 141 µM -0.270039867993665 0.387454391460056 no 2101 0.39356479115596 2910 56211 YIL048W NEO1 SGTC_1140 3229-1848 2.98 µM -0.270066889109714 0.387444500554639 no 2102 0.393554397291364 2991 2849525 SGTC_1411 3909-8223 150 µM -0.270344056505527 0.38734304943448 no 2103 0.393447787260471 3004 X1411 SGTC_285 1486-1325 46 µM -0.27089595684813 0.38714106118905 no 2104 0.393235527384875 3001 22310230 SGTC_2983 9022671 12.99 µM -0.271324134024558 0.386984375035933 no 2105 0.393070873071636 3079 6405161 SGTC_1115 galangin 695.678 nM -0.273328530676678 0.386251136089196 no 2106 0.392300342856485 3014 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1840 st055363 71 µM -0.273414664363234 0.386219636150478 no 2107 0.392267240779293 2907 676033 SGTC_1961 st076550 68.7 µM -0.275430049232696 0.385482804510017 no 2108 0.391492930281024 3003 1579337 SGTC_3163 9099914 49.47 µM -0.276965485092194 0.384921720987905 no 2109 0.390903304338548 2983 16268368 SGTC_2993 9054257 71.4286 µM -0.277345304775147 0.384782963273238 no 2110 0.390757487613344 2886 6470217 YGL055W OLE1 SGTC_36 0335-0881 14.2 µM -0.277673238892878 0.384663172534462 no 2111 0.390631602651041 2881 23828853 SGTC_1949 st076024 69.1 µM -0.277776325504639 0.384625518399248 no 2112 0.390592032880174 2831 2921930 SGTC_2898 9056270 58.44 µM -0.280297838037918 0.383704832848429 no 2113 0.389624504664397 2883 19154699 SGTC_1117 retinoic acid 1.10837 µM -0.281133873964003 0.383399713751575 no 2114 0.38930386038974 3063 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3105 9121040 49.47 µM -0.281679532587454 0.383200609538174 no 2115 0.389094624947151 2831 41448907 SGTC_1121 fusaric acid 630.51 nM -0.283563986873482 0.382513232566625 no 2116 0.388372269479178 2924 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_261 5-fluorouridine 15.376 µM -0.283599569726675 0.382500256852788 no 2117 0.388358633442771 3112 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2372 9071633 200 µM -0.285259483534349 0.381895096236532 no 2118 0.387722675622773 3031 21321366 SGTC_551 k048-0028 34.9 µM -0.285289520243024 0.381884148300946 no 2119 0.387711170516596 3066 6836383 SGTC_2360 9040895 200 µM -0.286653062218712 0.381387257045071 no 2120 0.387188990392845 2963 4914414 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.286731286030681 0.38135875725812 no 2121 0.387159040092064 2939 65057 A dermal irritant. YDR527W RBA50 SGTC_1372 2752-0194 270 µM -0.286739965650091 0.381355594995937 no 2122 0.387155716884374 2878 823334 SGTC_2776 terbinafine 19.92 µM -0.2869781572403 0.381268817294585 no 2123 0.387064522551576 2945 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1692 fluoroquinolonic acid 71 µM -0.287392368246368 0.381117926609308 no 2124 0.386905952050979 3040 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_417 st075190 100 µM -0.287534025980802 0.381066327026285 no 2125 0.386851726200091 3048 222757 SGTC_2762 leflunomide 42.06 µM -0.287763087855468 0.380982894495165 no 2126 0.386764047168288 2910 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_195 4234-0266 16.654 µM -0.288586067781446 0.380683181433944 no 2127 0.386449079196633 2949 2303354 SGTC_235 0330-0087 5 mM -0.289600399424708 0.38031388036121 no 2128 0.386060980696515 2948 46494818 YHR062C RPP1 SGTC_789 1309-1135 70.6 µM -0.290441251762532 0.380007822849877 no 2129 0.385739344376773 2895 3092424 SGTC_1915 st067105 30.6 µM -0.290557715611022 0.37996543769305 no 2130 0.385694801715834 2883 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_723 4182-0001 115 µM -0.29073682499827 0.379900256507096 no 2131 0.385626302638963 2922 744821 YLR208W SEC13 SGTC_2902 5787006 60.46 µM -0.291968676702281 0.379452055627211 no 2132 0.385155286686425 2921 591003 SGTC_1497 4476-2978 41.3 µM -0.292163706667018 0.379381110133209 no 2133 0.385080729730135 3004 1528379 SGTC_3086 9117350 49.47 µM -0.293801558307298 0.378785474003726 no 2134 0.384454772128519 2899 2679265 SGTC_165 k038-0023 64.381 µM -0.294480239477459 0.378538742842044 no 2135 0.384195480482547 2938 46368543 SGTC_1466 k213-0079 57.5 µM -0.294746518450217 0.378441951963061 no 2136 0.384093762157761 2922 3657981 SGTC_1831 st055328 12 µM -0.297906135308967 0.377294033039336 no 2137 0.38288740257619 3084 1103068 SGTC_53 0973-0023 39.979 µM -0.299561720675729 0.376692974981061 no 2138 0.382255743189269 2933 674768 SGTC_1206 3978-0017 132 µM -0.299746786627601 0.376625805573654 no 2139 0.38218515397307 3196 3873677 SGTC_2098 5376439 882.5 nM -0.300369753065357 0.37639972830515 no 2140 0.381947566321463 3037 2844116 SGTC_623 k072-0108 16.9 µM -0.300624419209446 0.376307321041443 no 2141 0.381850454252335 2998 5382803 SGTC_2639 lactacystin 53 µM -0.302093852559572 0.375774266234741 no 2142 0.381290259301319 3080 3870 A proteasome inhibitor. SGTC_3115 9123671 49.47 µM -0.302344437657656 0.375683387071082 no 2143 0.381194753037571 2986 3286988 SGTC_2437 5741531 144.16 µM -0.302480876060846 0.375633908145483 no 2144 0.381142754894245 3124 2262990 SGTC_975 1335-0046 28.5 µM -0.302643874258642 0.375574800081437 no 2145 0.381080637340708 2963 16486740 SGTC_9 0092-0002 10.449 µM -0.3026802111642 0.375561623621256 no 2146 0.381066789999862 2990 759368 SGTC_2274 7947094 46.08 µM -0.303410980094904 0.37529666359574 no 2147 0.380788339462579 2945 2971028 SGTC_1687 st020778 55.3625 µM -0.304884622466418 0.374762533751057 no 2148 0.380227014013193 2972 4259299 SGTC_298 1391-0729 10 µM -0.304911127908169 0.374752928902461 no 2149 0.380216920124401 2941 3237558 SGTC_182 3448-4371 550.524 µM -0.305704411263146 0.374465500653031 no 2150 0.37991485715487 2944 3491403 SGTC_1967 st070177 51.4 µM -0.306095406584874 0.374323858007289 no 2151 0.379766002601264 3101 5729214 SGTC_1047 2043-3044 82 µM -0.306456421116627 0.374193091314108 no 2152 0.379628577753516 2962 669592 SGTC_1431 4049-0260 9.09 µM -0.309777362358076 0.372990860617974 no 2153 0.378365133797634 2927 3854841 SGTC_72 0744-0168 198.391 µM -0.310737340762402 0.372643563721401 no 2154 0.378000153851961 2910 677577 SGTC_2267 7931562 200 µM -0.312166723061539 0.372126639764375 no 2155 0.377456910230775 2912 934880 SGTC_510 ag-490 170 µM -0.312840248283875 0.371883144881705 no 2156 0.377201017667866 3023 5328779 SGTC_2094 5332512 191.667 µM -0.314432750846995 0.371307622464528 no 2157 0.376596192497583 3113 755774 SGTC_1501 4491-0275 38.4 µM -0.316045830138774 0.37072495693703 no 2158 0.375983861061047 3072 5104718 SGTC_2447 5741742 33.78 µM -0.316527763931384 0.370550933526962 no 2159 0.375800977525223 3056 1776504 SGTC_3096 9117468 49.47 µM -0.317600273153715 0.370163751958549 no 2160 0.375394083456795 3089 41316311 SGTC_3169 9102970 49.47 µM -0.318127754599747 0.369973376561018 no 2161 0.3751940156422 2985 17027839 SGTC_1028 k015-0029 4.8 µM -0.319617153674648 0.369436003808726 no 2162 0.374629284606432 2952 4588309 SGTC_2899 9053889 58.44 µM -0.321412720917386 0.368788505125151 no 2163 0.373948822117742 3089 6470052 SGTC_1448 4255-0083 152 µM -0.324366370895433 0.367724201335123 no 2164 0.372830338340281 3129 5399660 SGTC_75 0159-0059 199.013 µM -0.325001943229252 0.367495314725751 no 2165 0.372589800490461 3269 5377270 SGTC_3277 9138724 49.47 µM -0.326295975341319 0.367029444659798 no 2166 0.372100216479674 3018 15943418 SGTC_1734 st037168 69.4 µM -0.329564556824722 0.365853581550681 no 2167 0.370864503600711 3068 708907 SGTC_2305 7443522 69.23 µM -0.32992042888059 0.365725633376819 no 2168 0.370730043476755 2971 5415886 SGTC_2719 novobiocin 32.65 µM -0.33332429215866 0.364502584643701 no 2169 0.369444752174585 3110 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.334956247741008 0.363916691457182 no 2170 0.368829045405079 3023 97141 SGTC_2325 6158266 200 µM -0.335615777780629 0.363680001778427 no 2171 0.368580312259884 3064 3623240 SGTC_1507 4075-3230 155 µM -0.336245404876019 0.363454092085917 no 2172 0.368342907981677 3019 659771 SGTC_468 gf-109203x 121 µM -0.336922259338019 0.363211290206312 no 2173 0.36808775242464 3049 2396 A protein kinase C inhibitor. SGTC_1124 fisetin 1.16336 µM -0.33709908261273 0.36314786904217 no 2174 0.368021104483515 3056 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_294 k038-0071 157 µM -0.338515369623674 0.362640025217272 no 2175 0.367487423379648 3058 24152826 SGTC_2129 girgensonine 121.053 µM -0.339708486475378 0.36221239183743 no 2176 0.367038035077484 3057 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2252 omeprazole 400 µM -0.339773347047777 0.362189149626705 no 2177 0.367013610511038 3011 4594 A proton pump inhibitor. SGTC_1839 st053978 48 µM -0.340046313831225 0.362091339970932 no 2178 0.366910825222717 3097 3788398 SGTC_208 k072-0098 12.366 µM -0.34042674480145 0.361955038691337 no 2179 0.366767590349093 3005 5948901 SGTC_1011 4112-3381 17.4 µM -0.34089040614945 0.361788941200767 no 2180 0.366593043748402 3159 2877139 SGTC_1928 4'-methoxychalcone 40.3 µM -0.341463561757387 0.361583655544664 no 2181 0.366377315860678 3209 641818 SGTC_3247 9135149 49.47 µM -0.351847784227964 0.357871317204814 no 2182 0.36247621018317 3035 8934436 YOR116C RPO31 SGTC_726 3448-4391 34.2 µM -0.352331960212736 0.357698549630086 no 2183 0.362294661060626 3199 1356692 SGTC_1948 st076329 66.6 µM -0.352991026941385 0.357463422984312 no 2184 0.362047583777898 2949 24208413 SGTC_2374 9071832 200 µM -0.353067362191596 0.357436193346102 no 2185 0.362018970196276 3001 17381698 SGTC_983 1491-0821 12.2 µM -0.3537066827835 0.357208169041195 no 2186 0.361779356915083 3147 46495113 SGTC_1345 1488-0192 31.4 µM -0.35507371980876 0.356720763742417 no 2187 0.361267182043531 3183 658348 SGTC_372 0155-0182 15.9 µM -0.35514372885704 0.356695808906038 no 2188 0.36124095909676 2995 771486 SGTC_443 clozapine 122 µM -0.355171945350581 0.356685751265545 no 2189 0.361230390367128 3096 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3065 9113888 49.47 µM -0.356881972875202 0.356076405985072 no 2190 0.360590082880887 3218 16648368 SGTC_1956 st077085 54 µM -0.357611850578362 0.355816435676576 no 2191 0.360316904290198 3070 24208685 SGTC_324 1315-0088 19.6 µM -0.358661652624826 0.355442631212273 no 2192 0.35992410948217 3108 6787421 SGTC_758 0868-0029 16 µM -0.362597916700019 0.35404228062678 no 2193 0.358452633371931 3153 762687 SGTC_2444 5485484 36.41 µM -0.362703557091453 0.354004725483477 no 2194 0.358413171123433 3163 6790631 SGTC_2061 5245884 80.95 µM -0.362879741177756 0.353942095226874 no 2195 0.358347360454393 3024 573863 SGTC_1402 3909-7673 35.9 µM -0.36602877164504 0.352823339841481 no 2196 0.357171803224622 3005 5328014 SGTC_1086 cerivastatin 2.18 µM -0.366344261617456 0.352711325698925 no 2197 0.357054102863897 3127 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2018 5133068 143 µM -0.368442960107778 0.351966511991125 no 2198 0.356271484683355 3000 785362 SGTC_576 1073-0113 22.7 µM -0.369159949635062 0.351712187265683 no 2199 0.3560042531561 3155 5439563 SGTC_931 2812-0076 566 µM -0.369605218457063 0.351554278499314 no 2200 0.355838331138063 3008 3450959 SGTC_482 fipronil 114 µM -0.369835216009515 0.351472722904298 no 2201 0.355752637069401 3117 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_968 1309-0633 340 µM -0.37203736462517 0.35069220232441 no 2202 0.354932514968247 3163 3761976 SGTC_1257 0669-0121 16 µM -0.373380597123106 0.350216421484011 no 2203 0.354432599155503 3124 4307855 SGTC_1702 st027038 51 µM -0.373491032395447 0.350177315105674 no 2204 0.354391509192145 3111 5521182 SGTC_19 0279-0214 38.434 µM -0.373794762050965 0.350069769194957 no 2205 0.35427850838395 3073 3566274 YBR002C RER2 SGTC_351 caspofungin 25 nM -0.37382144017577 0.350060323463418 no 2206 0.354268583559364 3086 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_718 1130-0073 349 µM -0.374645341682494 0.349768656288398 no 2207 0.353962123596761 3225 6740020 SGTC_2343 7990716 14.84 µM -0.375381129218705 0.349508257023127 no 2208 0.353688518616728 3035 6456862 SGTC_3046 9092212 49.47 µM -0.375425392777642 0.349492594162205 no 2209 0.353672061477089 3126 25236637 SGTC_934 2950-0684 338 µM -0.375918702660626 0.349318051571783 no 2210 0.353488667951542 3253 1121253 SGTC_1572 epiandrosterone 68.9 µM -0.376902581434795 0.348970031379665 no 2211 0.353123001479657 3015 441302 A steroid. SGTC_2186 6124449 200 µM -0.377376965559617 0.348802276339307 no 2212 0.352946741222294 3194 3834182 YLR033W RSC58 SGTC_1055 3448-0672 86 µM -0.378005358432264 0.348580105152638 no 2213 0.352713306678833 3212 748378 SGTC_448 monastrol 171 µM -0.37940814671826 0.348084330347506 no 2214 0.352192400908597 3116 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2067 5224629 34.075 µM -0.379811927075851 0.347941673966506 no 2215 0.352042514065251 3217 2835000 SGTC_1667 st014849 34.6 µM -0.379859399271802 0.34792490336129 no 2216 0.352024893475466 3091 5348460 SGTC_3226 9131256 49.47 µM -0.380455584456963 0.347714313069997 no 2217 0.351803630279039 3128 17178073 SGTC_1553 gossypol 38.6 µM -0.38085701449811 0.34757254253326 no 2218 0.351654675148038 3058 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2076 5212012 200 µM -0.380984098705886 0.347527665439863 no 2219 0.351607523868275 3090 604802 SGTC_3282 9108498 15.4605 µM -0.381049131782538 0.347504701214253 no 2220 0.351583395924823 3156 16459645 SGTC_3261 9137475 49.47 µM -0.381531363049362 0.347334435062109 no 2221 0.351404501802078 3108 17027690 SGTC_2780 5215298 71.43 µM -0.381541103296331 0.347330996294259 no 2222 0.351400888785677 3223 2834131 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.382276041106086 0.347071564754012 no 2223 0.351128312028578 3040 23665772 A membrane-active detergent. SGTC_797 k781-0471 270 µM -0.383432337962439 0.346663539431502 no 2224 0.350699614946795 3068 23738129 SGTC_1694 st024011 44.9 µM -0.383486074636712 0.346644581558835 no 2225 0.350679696690738 3180 2787533 SGTC_1112 tnp00069 1.16933 µM -0.383522346962039 0.346631785187119 no 2226 0.350666252073915 3178 145826 SGTC_1614 st002383 48.6 µM -0.383621259251096 0.346596891196966 no 2227 0.350629590422408 3164 1947235 SGTC_2193 5925765 200 µM -0.384989412800085 0.346114371582068 no 2228 0.350122629745639 3164 877370 SGTC_605 1315-0399 119 µM -0.385041249812234 0.346096094639448 no 2229 0.350103427111231 3228 24020461 SGTC_2539 epi(13)torulosol 80 µM -0.385829162638621 0.345818332711419 no 2230 0.349811597895654 3176 6708597 SGTC_1904 st060225 78 µM -0.386765901696043 0.345488213210613 no 2231 0.349464761460569 3145 66595 SGTC_1615 st002656 86.5 µM -0.386949876127974 0.345423391930188 no 2232 0.349396657951259 3141 1584458 SGTC_870 0573-2213 57.6 µM -0.387560754243941 0.345208188559929 no 2233 0.349170558360244 3132 3916321 SGTC_1568 digitonin 820 nM -0.387717310678336 0.345153044085359 no 2234 0.349112621951719 3252 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2980 9014342 25.29 µM -0.387792813474121 0.345126450620513 no 2235 0.34908468209688 3231 2996599 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.389410713248483 0.344556780720655 no 2236 0.348486174115527 3029 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.389445923899309 0.344544386802844 no 2237 0.34847315286243 3380 5282309 SGTC_1665 st014639 11.4 µM -0.390532039701829 0.344162163201271 no 2238 0.348071584073271 3137 981133 YIL048W NEO1 SGTC_2939 9044578 71.43 µM -0.391244817268325 0.343911410475539 no 2239 0.347808141878194 3043 2653634 SGTC_1189 1431-2119 7.28 µM -0.391359944331735 0.343870915601481 no 2240 0.347765597866586 3142 3107275 SGTC_1091 telmisartan 47.6 µM -0.391533580635852 0.343809844033744 no 2241 0.347701435997982 3209 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1157 4092-0394 27.6 µM -0.391535802487441 0.343809062587862 no 2242 0.34770061501044 3274 3659885 SGTC_1700 st030840 7.9285 µM -0.391988487576217 0.343649862951088 no 2243 0.347533360045232 3194 5499307 SGTC_2750 bromebric acid 70.15 µM -0.392129510578122 0.343600273848586 no 2244 0.347481261900006 3247 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2216 7189485 200 µM -0.393040995010502 0.343279825870975 no 2245 0.347144601616195 3197 731273 SGTC_955 1216-0110 33 µM -0.393810797947152 0.343009276179926 no 2246 0.346860365856494 3084 3619719 SGTC_1705 st027868 56.3335 µM -0.394215369015949 0.342867120639706 no 2247 0.346711019862324 3157 292948 SGTC_2465 5809242 33.21 µM -0.394467009157814 0.342778712188717 no 2248 0.346618139797407 3104 2731748 SGTC_3069 9117009 49.47 µM -0.394551239233173 0.342749121653055 no 2249 0.346587052639993 3116 41904981 SGTC_677 0929-0063 136 µM -0.39458076513291 0.342738749253994 no 2250 0.34657615563329 3151 1539583 SGTC_568 1193-0097 7.48 µM -0.396660645276096 0.342008389566943 no 2251 0.345808862437714 3172 3646150 SGTC_1341 1486-1360 280 µM -0.396728620667703 0.341984529643714 no 2252 0.345783796148048 3095 3976547 SGTC_2459 5811157 9.22 µM -0.396950842272199 0.341906532431171 no 2253 0.345701855459 3133 2870684 YBR192W RIM2 SGTC_2933 9026794 32.47 µM -0.397045717872287 0.341873234248059 no 2254 0.345666873789 3122 17586027 SGTC_1876 myriocin 605 nM -0.397112266538396 0.341849878611507 no 2255 0.345642337355249 3269 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_449 xestospongin c 11.1929 µM -0.397270513402162 0.341794343396896 no 2256 0.345583994482286 3191 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1859 st055998 20 µM -0.397862029856786 0.341586786711236 no 2257 0.34536594511647 3287 676301 SGTC_1079 idarubicin 2.36 µM -0.398007637389644 0.341535701955815 no 2258 0.345312278010007 3216 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_244 nsc-207895 1.295 µM -0.398774668532278 0.341266645696799 no 2259 0.345029621873217 3054 42640 SGTC_1317 1273-0028 910 nM -0.399042879862155 0.341172582578867 no 2260 0.344930804584812 3106 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2384 9036245 200 µM -0.399901553690488 0.340871507567767 no 2261 0.344614513939674 3128 6462766 SGTC_1178 0988-0033 191 µM -0.401085952792882 0.340456390476544 no 2262 0.344178421327996 3218 5392207 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.402128574039808 0.340091124636968 no 2263 0.343794702339957 3117 390807 SGTC_3185 9108267 49.47 µM -0.402140340375868 0.340087003343002 no 2264 0.343790372857613 3201 4910486 SGTC_3077 9117319 49.47 µM -0.402710495467764 0.339887322894928 no 2265 0.343580605989581 3143 17154678 SGTC_2214 7179297 48.276 µM -0.403345213336855 0.339665084019733 no 2266 0.343347142354506 3141 769744 SGTC_1605 st000082 49.1 µM -0.403743628385221 0.339525612217585 no 2267 0.343200626783659 3219 1114022 SGTC_3297 9117502 71.43 µM -0.403811590932555 0.339501822993041 no 2268 0.343175636175852 3210 7453720 SGTC_736 0958-0254 92.6 µM -0.404366982035521 0.339307441015794 no 2269 0.342971438211679 3225 6812352 SGTC_2109 5483026 200 µM -0.404829831104534 0.339145480590984 no 2270 0.342801299757807 3158 759335 SGTC_1150 3909-7983 10.9 µM -0.405340328241025 0.338966881591617 no 2271 0.342613683344223 3140 23965914 SGTC_1039 k821-0043 94 µM -0.405364669444328 0.338958366650073 no 2272 0.342604738505686 3238 15992768 SGTC_94 0334-0113 514.748 µM -0.405420528096666 0.338938826712702 no 2273 0.342584212055209 3149 6795178 SGTC_1958 st076513 41.9 µM -0.405794251543339 0.338808105515675 no 2274 0.342446891383369 3093 732122 YGL099W LSG1 SGTC_2428 5615643 7.78 µM -0.407222242388936 0.338308800977775 no 2275 0.341922383398928 3208 2253075 SGTC_1868 st057644 42.7 µM -0.409878002642658 0.337380956650146 no 2276 0.340947721284852 3085 688665 SGTC_2551 apiole 73.87 µM -0.41044187423564 0.337184083505561 no 2277 0.340740917091081 3148 10659 A possible DNA adduct former. SGTC_2950 9072895 21.46 µM -0.410722696078037 0.337086052490737 no 2278 0.340637941393656 3248 17332245 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.412219379463805 0.336563767788342 no 2279 0.34008931699896 3086 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2024 5144227 134 µM -0.414041393274821 0.335928380706446 no 2280 0.339421896252091 3251 3475211 SGTC_899 1083-0020 478 µM -0.414437155554982 0.335790429238369 no 2281 0.339276991288862 3282 767123 SGTC_97 0535-0701 19.132 µM -0.414460792118887 0.335782190904799 no 2282 0.339268337715665 3149 2832013 YGL099W LSG1 SGTC_1989 st071868 50.2 µM -0.417346683434502 0.334776930851817 no 2283 0.338212423421964 3246 16414057 SGTC_2526 patulin 37.61 µM -0.417359245578829 0.334772557584518 no 2284 0.338207829851542 3269 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_115 0527-0192 112.043 µM -0.417529857187528 0.334713164675836 no 2285 0.338145445081977 3241 4233931 SGTC_1525 8-methoxypsoralen 92.5 µM -0.419536705683411 0.334014856060098 no 2286 0.337411967427671 3353 4114 Related to psoralen; DNA damaging agent. SGTC_713 1488-1073 324 µM -0.420922065265232 0.333533137350201 no 2287 0.336905996079493 3197 3312542 SGTC_2058 5236698 133 µM -0.422708475068915 0.332912370066329 no 2288 0.336253985697647 3157 766665 SGTC_903 1134-0042 114 µM -0.423254155617421 0.332722840341153 no 2289 0.336054919267556 3154 701009 SGTC_944 3370-0224 231 µM -0.423494780897915 0.332639278200283 no 2290 0.335967152812624 3166 4580514 SGTC_2322 7413319 38.22 µM -0.424521606819614 0.332282784997755 no 2291 0.335592725515722 3244 1840400 SGTC_3174 9107204 49.47 µM -0.425719835663488 0.331866975964293 no 2292 0.335156003275985 3262 3938802 SGTC_1149 3909-7961 23.3 µM -0.425926341221072 0.331795335363037 no 2293 0.335080760030449 3182 735261 SGTC_2253 7938677 135.83 µM -0.427036384263222 0.331410346323448 no 2294 0.334676413475846 3304 2301972 SGTC_2077 5212015 200 µM -0.4274522689432 0.331266153568075 no 2295 0.334524971793803 3130 780900 SGTC_2025 5147754 141 µM -0.428778340584678 0.33080655399453 no 2296 0.334042271357079 3185 315777 YLR208W SEC13 SGTC_2138 5575593 77.673 µM -0.431751909547415 0.329776880343382 no 2297 0.332960867537534 3166 762213 SGTC_924 2046-0044 21.3 µM -0.433035284694384 0.329332876805756 no 2298 0.332494568089677 3179 3623589 SGTC_3241 9133421 49.47 µM -0.433301488450386 0.329240809591181 no 2299 0.332397878469678 3222 17018221 SGTC_2481 5478948 45.16 µM -0.434393617171392 0.328863202651655 no 2300 0.332001315991592 3296 77792 SGTC_2132 5317594 122.667 µM -0.434485780085148 0.328831345018728 no 2301 0.331967859348873 3124 794577 SGTC_2742 clothiapine 36.27 µM -0.435669344890552 0.328422336903834 no 2302 0.331538325150621 3228 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.435753711435391 0.328393189940473 no 2303 0.331507715659338 3208 6708630 An antioxidant. SGTC_1237 0330-0133 46.1 µM -0.438860150303946 0.327320705563975 no 2304 0.33038143643554 3140 X1237 YHR072W ERG7 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.439713853812351 0.327026217219052 no 2305 0.330072183698795 3164 2333 A French combination drug. SGTC_3276 9139060 49.47 µM -0.441070299734792 0.326558527433874 no 2306 0.329581052116558 3221 4870619 SGTC_1803 st050068 52.4 µM -0.442143545908468 0.326188675288021 no 2307 0.329192667459404 3299 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3219 9131112 49.47 µM -0.442737617031014 0.325984025453162 no 2308 0.328977765124637 3268 17612988 YMR079W SEC14 SGTC_751 0833-0568 350 µM -0.444587081927518 0.325347244437232 no 2309 0.328309092330682 3256 6954252 SGTC_1285 0929-0069 65.5 µM -0.445085174060797 0.325175835575437 no 2310 0.328129101315387 3219 1206237 SGTC_253 dyclonine 31.25 µM -0.445789507717131 0.324933515781787 no 2311 0.327874650788064 3276 3180 An oral anasthetic. SGTC_1398 3558-0053 112 µM -0.446035962394627 0.324848742702506 no 2312 0.327785634399532 3108 4532369 SGTC_588 3970-1144 52.9 µM -0.450636812123467 0.323267856271326 no 2313 0.326125665255746 3270 1888707 SGTC_257 daunorubicin 18.5 µM -0.453097233610224 0.32242374250609 no 2314 0.325239363643149 3307 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2779 methotrexate 400 µM -0.45321657773198 0.322382821521134 no 2315 0.325196398164326 3305 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2799 7812892 81.82 µM -0.453260174079572 0.322367873642581 no 2316 0.32518070347603 3329 20205235 SGTC_777 1315-0167 517 µM -0.453589566113921 0.322254944288433 no 2317 0.325062132345048 3255 4221767 SGTC_446 go6976 132 µM -0.454473786232442 0.321951877827138 no 2318 0.324743927579 3294 3501 A protein kinase C inhibitor. SGTC_2121 5257820 149.641 µM -0.454683393066011 0.321880052431784 no 2319 0.324668514993836 3319 791256 SGTC_264 promethazine 12.5 mM -0.457856028832109 0.320793708016984 no 2320 0.323527939647907 3355 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_198 3454-2873 16.191 µM -0.458126429042669 0.32070119084955 no 2321 0.323430806120378 3227 710957 SGTC_3051 9093778 49.47 µM -0.45903598028588 0.320390070538343 no 2322 0.323104164235504 3260 17217378 SGTC_292 k038-0015 474 µM -0.45968780298175 0.320167186236665 no 2323 0.322870162773041 3314 46368540 SGTC_633 0437-0093 97.7 µM -0.463315487977703 0.318927922437852 no 2324 0.321569122891582 3236 2831118 SGTC_1228 0124-0032 52.5 µM -0.464257399729193 0.318606483308006 no 2325 0.321231670616501 3306 X1228 SGTC_2031 5180455 200 µM -0.465686650255462 0.318118994420717 no 2326 0.320719904669157 3224 29949 SGTC_529 4076-0302 30.3 µM -0.466761806227441 0.317752487620821 no 2327 0.320335152298655 3220 5816522 SGTC_2918 7977171 22.06 µM -0.469538881224935 0.316806645214197 no 2328 0.319342249932294 3260 2236483 SGTC_141 0443-0274 32.331 µM -0.472121096421751 0.315928242900248 no 2329 0.318420177551755 3402 1627241 SGTC_1183 1254-0324 198 µM -0.473402682967888 0.315492665777094 no 2330 0.317962958048051 3343 5799357 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.475280629485833 0.3148548647309 no 2331 0.317293481904903 3279 688788 SGTC_2103 5378138 10 µM -0.475889321813321 0.314648254799572 no 2332 0.317076614994128 3368 244142 SGTC_2862 9027634 71.43 µM -0.476097231950956 0.314577696641336 no 2333 0.317002554472311 3186 5012562 SGTC_1019 4262-0212 3.4 µM -0.47905177660681 0.313575749966883 no 2334 0.315950897458483 3335 4677213 SGTC_1487 3970-0795 2.82 µM -0.480518622909378 0.313078822144913 no 2335 0.315429332158867 3333 3765103 SGTC_2113 5491891 107.031 µM -0.48160437903502 0.312711215833477 no 2336 0.31504350740593 3277 789979 SGTC_687 k029-0044 34.9 µM -0.481731723849384 0.312668112675434 no 2337 0.314998268480812 3351 5829338 SGTC_669 0108-0021 26.2 µM -0.482383696736759 0.312447475670913 no 2338 0.314766700238693 3530 17201 SGTC_3059 1327-0034 3 µM -0.48280251855502 0.312305775796008 no 2339 0.314617981184738 3251 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2504 purpurogallin 52.29 µM -0.482803180217786 0.312305551957774 no 2340 0.3146177462593 3213 5281571 An antioxidant. SGTC_3294 9122953 26.2835 µM -0.483745532895685 0.311986827629114 no 2341 0.314283237192823 3282 16459826 SGTC_637 1181-0519 7.26 µM -0.484336027684239 0.311787181045822 no 2342 0.314073705600369 3332 6252091 YGR060W ERG25 SGTC_544 k015-0020 52.4 µM -0.487067205672476 0.310864488509992 no 2343 0.313105352792587 3291 3008304 SGTC_1339 1486-1321 22.7 µM -0.487817595801688 0.31061118686931 no 2344 0.312839523420282 3268 3469382 SGTC_1009 4106-0057 9.87 µM -0.488553514518531 0.310362857372635 no 2345 0.312578915109526 3391 2928005 SGTC_2593 nobiletin 86.24 µM -0.489008955602547 0.310209215947005 no 2346 0.312417678279653 3289 72344 An anti-infammatory. SGTC_587 k089-0003 57 µM -0.493157352438989 0.308811296592054 no 2347 0.310950704617106 3345 9659696 SGTC_2506 ethyl hematommate 54.16 µM -0.493832442468001 0.308584067065859 no 2348 0.310712259562729 3319 3940691 An allergen. SGTC_55 0767-0285 6.563 µM -0.493914916873585 0.308556311908523 no 2349 0.310683134651303 3360 3116166 SGTC_2483 5729050 27.16 µM -0.494339411051973 0.308413473954549 no 2350 0.310533248063674 3419 2865180 SGTC_2614 arthonioic acid 13.39 µM -0.495722937363074 0.307948132832959 no 2351 0.310044950836904 3325 6710684 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.496130797353086 0.307811010342361 no 2352 0.30990106593517 3377 5282362 SGTC_1437 4092-1038 11.6 µM -0.497116163760494 0.307479841013545 no 2353 0.309553568405952 3277 3977136 SGTC_1291 0993-0025 5.79 µM -0.497443407297733 0.307369893237751 no 2354 0.309438200924239 3404 4353356 SGTC_3325 9138760 55.175 µM -0.49811229694693 0.307145212541438 no 2355 0.309202446861319 3256 43844959 SGTC_2888 9058547 12.99 µM -0.499159590180604 0.306793571116745 no 2356 0.308833480022474 3263 16476514 SGTC_2516 gossypol 71.55 µM -0.501656269544179 0.305955997956111 no 2357 0.307954665296442 3412 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2301 7769476 200 µM -0.503132214063756 0.305461332098135 no 2358 0.307435659616079 3316 977820 SGTC_54 0159-0055 9 µM -0.503174095556146 0.305447300604255 no 2359 0.307420937896312 3478 3319099 SGTC_2830 7992007 71.43 µM -0.504310934514324 0.305066536365269 no 2360 0.307021447385559 3274 1952075 SGTC_3122 9126309 49.47 µM -0.504875783997959 0.304877428360409 no 2361 0.306823041765216 3394 17591206 SGTC_472 calcifediol 10 µM -0.50637190911061 0.304376787112854 no 2362 0.306297795385734 3340 5283731 A vitamin D metabolite. SGTC_3102 9121669 49.47 µM -0.506477165137294 0.304341579571603 no 2363 0.306260857996658 3302 41905072 SGTC_912 3474-0017 2.18 µM -0.509118136823803 0.303458783832797 no 2364 0.305334709842591 3420 3360550 SGTC_1503 4585-0012 61.3 µM -0.510061272708961 0.303143799896281 no 2365 0.305004267900556 3415 2922052 SGTC_2859 9028643 45.46 µM -0.511138230541441 0.302784301688714 no 2366 0.304627133772496 3337 17151580 SGTC_409 arachidonic acid 100 µM -0.511724812731436 0.302588575631053 no 2367 0.304421808965381 3299 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1135 dihydrocapsaicin 536.708 nM -0.512400664854897 0.30236313302708 no 2368 0.304185312886417 3316 107982 A Capsaicinoid. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.51292367928858 0.302188723905134 no 2369 0.304002354401522 3332 442882 SGTC_146 3448-8650 53.125 µM -0.515931932996893 0.301186442449386 no 2370 0.302950975068379 3304 2891488 YIL048W NEO1 SGTC_1331 1472-0049 76.2 µM -0.516231775371522 0.301086623941198 no 2371 0.302846269935364 3278 24051409 SGTC_2837 9008476 45.46 µM -0.516405261982227 0.301028876489933 no 2372 0.30278569570966 3426 2992805 SGTC_1452 4194-0072 190 µM -0.516505188473233 0.30099561682225 no 2373 0.302750808045914 3429 1343545 SGTC_1491 4138-0063 26.5 µM -0.517579452004388 0.300638162192663 no 2374 0.302375860675863 3365 23883227 SGTC_1632 st005650 90 µM -0.517848097020087 0.300548802165248 no 2375 0.302282128778417 3354 2759605 SGTC_192 3455-0609 60.9 µM -0.518674707755746 0.300273919939877 no 2376 0.301993801016543 3425 3769639 SGTC_703 3875-0075 71.8 µM -0.519816653953125 0.299894362699572 no 2377 0.301595685317145 3362 2850814 SGTC_833 3852-0053 558 µM -0.521611301242257 0.299298301550709 no 2378 0.300970496550317 3459 3123681 SGTC_310 1273-0058 1.06 µM -0.523099161180809 0.298804542387225 no 2379 0.300452624611371 3412 2734232 SGTC_2046 4110841 106 µM -0.524341710149022 0.298392475670022 no 2380 0.300020445530684 3445 44119630 YMR134W ERG29 SGTC_2311 7694451 200 µM -0.524435909304067 0.29836124693828 no 2381 0.299987692979218 3310 2163142 SGTC_861 0443-0273 110 µM -0.524557653149032 0.298320888845178 no 2382 0.299945365680588 3375 6149169 SGTC_835 0312-0010 67.2 µM -0.526781080407367 0.297584260139605 no 2383 0.299172811401402 3336 1626196 SGTC_1364 1653-0028 37.6 µM -0.526944921276384 0.297530011984503 no 2384 0.299115918828647 3378 5718652 SGTC_2460 5552655 174.22 µM -0.527299822849358 0.29741251859821 no 2385 0.298992698633755 3416 5401989 SGTC_3173 9105693 49.47 µM -0.52731557602574 0.297407303857449 no 2386 0.298987229737679 3485 17096658 SGTC_2984 9022109 38.96 µM -0.530127911945585 0.296477012269985 no 2387 0.298011623955334 3463 6459207 SGTC_122 0236-0016 402.397 µM -0.53064344411241 0.296306624308575 no 2388 0.297832942136468 3437 6808838 SGTC_2960 9079389 5.97 µM -0.530860651888398 0.296234848656389 no 2389 0.297757673240176 3429 16457355 SGTC_2099 5377090 177.372 µM -0.531363355382697 0.296068762402243 no 2390 0.297583504952777 3388 2243829 SGTC_688 0527-0193 473 µM -0.531991674809243 0.295861234498372 no 2391 0.297365880769951 3321 4007154 SGTC_1685 st024049 53.0905 µM -0.53241183036892 0.295722498417254 no 2392 0.297220396622029 3385 1941139 SGTC_2010 4012422 159 µM -0.532652811620236 0.295642939490283 no 2393 0.297136968515302 3338 952393 SGTC_2073 5212005 126 µM -0.532680311279294 0.295633861221182 no 2394 0.297127448768609 3333 691789 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.533458993811084 0.295376853433847 no 2395 0.296857944763558 3299 279621 SGTC_525 k781-2675 26.7 µM -0.533907709665501 0.295228799381973 no 2396 0.296702693890043 3444 3651118 YDL195W SEC31 SGTC_1315 1237-0019 3.69 µM -0.534324059289254 0.295091455147737 no 2397 0.296558674647184 3430 825140 SGTC_357 1325-0123 420 µM -0.534859635767992 0.294914823982265 no 2398 0.296373460828627 3417 1098503 SGTC_1412 3909-8563 178 µM -0.535262706458965 0.294781924881825 no 2399 0.29623410533283 3466 23767530 SGTC_1857 st056007 79.3 µM -0.535678393060818 0.294644895035241 no 2400 0.296090419568605 3430 619834 SGTC_741 4582-0002 126 µM -0.535866850673573 0.294582780227861 no 2401 0.296025288060333 3342 2912688 SGTC_1708 st033234 31.827 µM -0.535977307814079 0.294546376844472 no 2402 0.295987116803025 3480 674664 SGTC_1475 4092-1048 11.7 µM -0.538080233739179 0.293853711415959 no 2403 0.295260829016107 3426 2881759 SGTC_1885 st057546 99.9 µM -0.538854493384279 0.293598874330666 no 2404 0.294993629621926 3491 702008 SGTC_1929 genistein trimethyl ether 50.5 µM -0.538859756016176 0.293597142556738 no 2405 0.294991813852638 3476 136420 SGTC_1892 st058411 7.36 µM -0.539150194640039 0.293501575271823 no 2406 0.294891611611106 3418 3934738 SGTC_3146 9095609 49.47 µM -0.539191783334504 0.293487891912338 no 2407 0.294877264664324 3371 17173999 SGTC_2746 daunorubicin 9.88 µM -0.53930207218077 0.293451606512068 no 2408 0.294839219627359 3336 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.541785977867921 0.292634944228244 no 2409 0.293982976093768 3393 676296 Flavone; oxidizing agent. SGTC_2362 9071156 126 µM -0.544528169642717 0.291734590412011 no 2410 0.293039034550283 3455 653133 SGTC_2038 4100038 30.985 µM -0.544734098250982 0.291667029265971 no 2411 0.292968204774342 3420 3596803 SGTC_2262 9014885 67.46 µM -0.545293218038752 0.29148362979876 no 2412 0.292775933886194 3391 6457424 SGTC_3300 9124615 50.48 µM -0.546276326874156 0.291161286226744 no 2413 0.292438003214465 3494 24824903 SGTC_3212 9128307 49.47 µM -0.548686930562121 0.290371598248125 no 2414 0.291610158396916 3228 27243542 SGTC_1613 st002381 52.1 µM -0.54886135454452 0.290314497745434 no 2415 0.291550300465074 3444 551167 SGTC_64 000l-0018 272.079 µM -0.54999176836541 0.289944566092111 no 2416 0.291162509783236 3404 6811119 SGTC_160 3453-0671 289.699 µM -0.55353307390592 0.288787095399969 no 2417 0.289949219787474 3377 5322268 SGTC_133 0724-0033 378.92 µM -0.555547523885944 0.288129647419839 no 2418 0.289260106726048 3326 280309 SGTC_346 4513-0042 7.16 µM -0.555825555257212 0.288038962925158 no 2419 0.289165056860628 3427 2827372 SGTC_2798 7813637 45.45 µM -0.556428337471784 0.287842401890221 no 2420 0.288959035711801 3457 956368 SGTC_2228 7354201 200 µM -0.559627650920843 0.286800200842693 no 2421 0.28786672017185 3441 753451 SGTC_3017 9080681 49.47 µM -0.560104436246641 0.286645037608894 no 2422 0.287704102348508 3437 16451914 SGTC_2237 6667747 47.222 µM -0.560927239098363 0.286377361393606 no 2423 0.287423569992652 3300 729940 YDL015C TSC13 SGTC_1963 st076565 50.3 µM -0.562395967194203 0.285899846350537 no 2424 0.286923133055382 3445 4914280 SGTC_1258 0671-0043 57.1 µM -0.562478868836855 0.285872904536534 no 2425 0.286894898448533 3414 4298767 SGTC_2870 9038528 12.99 µM -0.562846635656799 0.285753400289549 no 2426 0.286769660455365 3456 6463316 SGTC_1726 st035556 14.5795 µM -0.563943290047035 0.285397188304994 no 2427 0.286396363641354 3521 5919439 SGTC_1051 3253-3903 78 µM -0.564387416131728 0.285252988789945 no 2428 0.286245250522924 3377 5509239 SGTC_330 1488-0319 80.1 µM -0.565041269415735 0.285040757932236 no 2429 0.286022847022826 3441 6846614 SGTC_3295 9122362 53.5725 µM -0.567041662618706 0.284391928567984 no 2430 0.285342938050785 3449 4730473 SGTC_2903 5923464 63.88 µM -0.568481321846629 0.283925410918634 no 2431 0.284854092511238 3482 2876576 SGTC_683 panaxydol 45 µM -0.568661256174657 0.283867129447658 no 2432 0.284793022755314 3464 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3320 9137005 35.139 µM -0.57022093473878 0.283362183228166 no 2433 0.2842639294229 3421 4908713 SGTC_1297 1068-0111 14.1 µM -0.571367822321727 0.282991153151996 no 2434 0.283875168165408 3405 767057 SGTC_2250 alverine citrate 130 µM -0.572019727220978 0.282780359140552 no 2435 0.283654305019578 3426 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1296 1068-0102 11.9 µM -0.5731820130428 0.282404720254907 no 2436 0.283260730891338 3448 767053 SGTC_2003 4023581 200 µM -0.576277098650782 0.281405592448407 no 2437 0.282213949898457 3489 16641307 SGTC_3214 9129694 49.47 µM -0.576618316803134 0.281295547944291 no 2438 0.282098661419567 3478 17158655 SGTC_1587 estradiol valerate 56.1 µM -0.577407057036286 0.281041254945953 no 2439 0.281832254034459 3516 13791 A steroid. SGTC_459 nigericin 15.3 µM -0.577447363968892 0.281028262813637 no 2440 0.281818643094826 3523 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2673 kobusone 100 µM -0.578031873464048 0.280839890511269 no 2441 0.281621300170213 3527 6710676 An epoxy ketone and protein crosslinker. SGTC_1 0258-0098 57.368 µM -0.580945740686885 0.279901738218882 no 2442 0.280638511597291 3405 6790032 YDR047W HEM12 SGTC_3005 9076496 71.4286 µM -0.583223640616089 0.279169402777123 no 2443 0.279871379322303 3495 21368410 SGTC_2610 ononetin 44.17 µM -0.58360451263377 0.279047044942451 no 2444 0.279743211710118 3454 259632 SGTC_775 4577-0580 57.3 µM -0.585973282790229 0.278286646775562 no 2445 0.278946734542039 3569 2006902 SGTC_2925 9010536 32.5 µM -0.587096729582773 0.277926362959815 no 2446 0.278569371950162 3463 2994177 SGTC_1810 st050138 53 µM -0.587901549733265 0.277668401166874 no 2447 0.27829918809657 3509 3444541 SGTC_716 1683-5115 658 µM -0.588143420015817 0.277590899514033 no 2448 0.278218015492351 3544 723597 SGTC_2698 st077697 67.5 µM -0.589422122890643 0.277181344932648 no 2449 0.277789069803988 3420 3154499 SGTC_433 pimozide 108 µM -0.589900655288663 0.277028152278868 no 2450 0.27762862738793 3369 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3053 9095903 49.47 µM -0.590562781340807 0.276816254124855 no 2451 0.277406704346145 3528 17174018 SGTC_1094 duloxetine 25.4 µM -0.591091346076269 0.276647156188692 no 2452 0.277229608969868 3491 60834 A selective serotonin reuptake inhibitor. SGTC_2283 7944793 200 µM -0.592227567571897 0.276283828732746 no 2453 0.276849105790044 3478 2970533 SGTC_1272 0839-0021 27 µM -0.59249270053091 0.276199081356275 no 2454 0.276760353641858 3486 5027250 SGTC_2617 dihydrotanshinone i 20.83 µM -0.593648734893644 0.275829714479266 no 2455 0.276373538941882 3481 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1087 pterostilbene 9.05 µM -0.594581854935415 0.275531748536038 no 2456 0.276061505987203 3543 5281727 Similar to reservatol, lowers cholesterol. SGTC_2843 9000894 45.46 µM -0.596837172797485 0.274812229836953 no 2457 0.275308048483149 3395 2242070 SGTC_1811 st050069 61.5 µM -0.598561056191253 0.2742628810375 no 2458 0.274732816111721 3506 3877702 SGTC_2206 7254556 146.969 µM -0.598821821301808 0.274179830430897 no 2459 0.274645854585968 3490 4398905 SGTC_3316 9136639 10.545 µM -0.599315448892984 0.27402264989715 no 2460 0.274481273855197 3510 4903665 SGTC_4 0960-0234 25.671 µM -0.600218910920727 0.273735085565386 no 2461 0.274180176036454 3516 6821112 SGTC_1065 prochlorperazine maleate 2.48 µM -0.600233822511196 0.273730340584526 no 2462 0.274175207802601 3555 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1201 1889-3372 45.9 µM -0.601341778769595 0.273377894380185 no 2463 0.273806184116499 3460 5392199 SGTC_617 3770-0098 35 µM -0.602101332095105 0.273136406719296 no 2464 0.273553343942133 3484 5962639 SGTC_2802 7925815 54.55 µM -0.60452443954182 0.272366726252259 no 2465 0.272747512850809 3482 1262923 SGTC_1336 1486-0901 104 µM -0.605085298453764 0.272188727632113 no 2466 0.272561161034296 3485 5006114 SGTC_3285 9112818 20.8695 µM -0.606279377334073 0.271809958000764 no 2467 0.272164625269744 3541 17017947 YPR165W RHO1 SGTC_550 4123-0385 25.7 µM -0.606385697495956 0.271776245270823 no 2468 0.272129331839642 3508 5731123 SGTC_782 0083-0095 30.5 µM -0.607706864155264 0.271357494310148 no 2469 0.271690954833232 3554 3591729 An indicator and reagent. SGTC_1723 st034307 2.5525 µM -0.608093830344639 0.271234904176452 no 2470 0.2715626219716 3517 867466 SGTC_26 0302-0163 425.158 µM -0.60944763739579 0.270806238113439 no 2471 0.271113885202262 3501 3100915 SGTC_2415 st077333 57.7 µM -0.610177454261552 0.270575291108032 no 2472 0.270872131507847 3605 2766255 SGTC_492 tmb-8 126 µM -0.610412700250237 0.270500869629447 no 2473 0.270794228610003 3444 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3071 9117417 49.47 µM -0.61066525765335 0.270420982966805 no 2474 0.270710605400712 3447 45595590 YGL055W OLE1 SGTC_2120 5538279 151.968 µM -0.611330297149346 0.270210680134756 no 2475 0.270490468694637 3535 2058197 SGTC_2534 helenine 20.12 µM -0.611737560364955 0.270081933277181 no 2476 0.270355703456586 3520 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3326 9140064 16.379 µM -0.612835066248502 0.269735135002826 no 2477 0.26999270097285 3513 1868434 SGTC_348 k064-0012 10.7 µM -0.613222217838862 0.269612853125813 no 2478 0.269864707953308 3470 5066323 SGTC_2431 5490079 200 µM -0.613224390847881 0.269612166859039 no 2479 0.269863989638312 3497 5722345 SGTC_1740 st038286 13.222 µM -0.614823879311554 0.269107263462326 no 2480 0.269335518745836 3556 716786 SGTC_502 l-744,832 89.3 µM -0.616779135551859 0.268490701607033 no 2481 0.26869020788681 3519 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2293 7624732 200 µM -0.61850547623445 0.267946915933756 no 2482 0.26812109454111 3525 894453 SGTC_180 1486-1293 102.781 µM -0.619352737496028 0.267680237390455 no 2483 0.267842004647011 3603 4140536 SGTC_2877 9040724 71.43 µM -0.619397849054407 0.267666042116086 no 2484 0.267827148895658 3561 6463895 SGTC_759 3486-0358 89.3 µM -0.620148194004561 0.267429986386022 no 2485 0.267580112620811 3590 875103 SGTC_1682 st012968 530 nM -0.623923028882779 0.266244032410095 no 2486 0.266339067836656 3450 24207270 SGTC_308 4092-1169 104 µM -0.624431006010357 0.2660846428057 no 2487 0.266172283862386 3528 2268590 YDL196W YDL196W SGTC_3275 9138069 49.47 µM -0.625642922127003 0.265704571290387 no 2488 0.265774589498705 3569 17617007 SGTC_1797 st048695 56.8 µM -0.626008590703568 0.265589947292048 no 2489 0.265654653300548 3541 592262 YIL048W NEO1 SGTC_1515 3460-0031 42.1 µM -0.626502266215361 0.265435237501033 no 2490 0.26549277546124 3528 2876596 SGTC_990 3985-0011 41.3 µM -0.626620325244835 0.265398246518408 no 2491 0.265454070929711 3506 5399565 YGL099W LSG1 SGTC_506 n9-isopropylolomoucine 153 µM -0.62793181461096 0.264987498615093 no 2492 0.265024304239526 3577 6610355 SGTC_2045 5106652 78.05 µM -0.628145126572094 0.264920721581068 no 2493 0.264954436710554 3544 673349 SGTC_1232 0279-0259 161 µM -0.62933295212474 0.264549030794886 no 2494 0.264565551314168 3569 1560000 SGTC_1166 k206-0078 225 µM -0.629455753281878 0.264510619365916 no 2495 0.264525363682456 3562 5404595 SGTC_1067 clotrimazole 1.36 µM -0.629540093472519 0.264484239929109 no 2496 0.264497764499823 3561 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1371 2421-0008 32.7 µM -0.62982775532772 0.264394276789665 no 2497 0.264403642085146 3544 2827552 SGTC_724 3910-0327 137 µM -0.630187346691773 0.264281840382315 no 2498 0.2642860084517 3562 2885483 SGTC_2404 5161160 200 µM -0.631800447441894 0.263777758577892 no 2499 0.263758640613651 3557 2831543 SGTC_3254 9136651 49.47 µM -0.633051780994242 0.263387064265075 no 2500 0.263349914559991 3546 16454030 SGTC_2569 tetrandrine 100 µM -0.633102305982595 0.263371295441666 no 2501 0.263333418258099 3501 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3306 9127676 59.7925 µM -0.635647164371772 0.262577670475936 no 2502 0.262503210535305 3546 41905287 SGTC_1988 st071872 53.4 µM -0.636631545406681 0.262271015643819 no 2503 0.26218243620468 3588 16414116 SGTC_2063 5246145 200 µM -0.637337892937513 0.262051087037643 no 2504 0.261952386807113 3592 711240 SGTC_1790 st045711 43.5 µM -0.638104958562146 0.261812360339933 no 2505 0.2617026794897 3604 585119 SGTC_725 1497-0963 19 µM -0.639273392825789 0.261448933916203 no 2506 0.261322547171884 3602 3549977 SGTC_1002 4049-0206 172 µM -0.639531249230859 0.261368765909605 no 2507 0.26123869573189 3596 4662749 SGTC_2671 danthron 100 µM -0.639792993533499 0.261287402063365 no 2508 0.261153594140687 3536 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_771 0250-0039 27.3 µM -0.641564230063414 0.260737151089633 no 2509 0.260578082166772 3553 3005115 SGTC_2036 5160441 105 µM -0.64166629491343 0.260705461881485 no 2510 0.260544939058832 3590 134534 YIL048W NEO1 SGTC_2793 7325131 81.82 µM -0.642673941344283 0.260392713106451 no 2511 0.260217846614382 3536 4176441 SGTC_1942 st076330 65.2 µM -0.64715256086565 0.259005001302853 no 2512 0.258766605277916 3635 24208414 SGTC_312 4092-0653 6.84 µM -0.647199512408076 0.258990473531988 no 2513 0.258751413427713 3587 1148278 SGTC_2860 9025725 38.96 µM -0.647332332570816 0.258949378530233 no 2514 0.258708440044348 3521 40546248 SGTC_1683 st010134 710 nM -0.647773118013035 0.258813022217809 no 2515 0.258565852318888 3608 3818134 SGTC_1945 st075991 56.6 µM -0.648757974482652 0.258508492660628 no 2516 0.258247412581808 3522 1084980 SGTC_213 1246-0773 967 nM -0.650529359539468 0.25796122639138 no 2517 0.257675171724637 3548 6251622 SGTC_2405 ticlatone 3.52 µM -0.652925355946506 0.257221944966925 no 2518 0.256902200737982 3499 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2092 5303694 80.6725 µM -0.653530685040226 0.257035345937992 no 2519 0.256707106970599 3586 1963699 SGTC_3313 9133968 57.047 µM -0.653558316433864 0.257026829952373 no 2520 0.256698203387095 3587 1494643 SGTC_1809 st050081 57.6 µM -0.657335736419656 0.255864013385164 no 2521 0.255482531449962 3670 5036894 SGTC_2820 7989630 71.43 µM -0.660218511982596 0.25497844911841 no 2522 0.254556807141491 3514 2984098 SGTC_632 0781-2353 4.65 µM -0.660258574004742 0.254966153712165 no 2523 0.254543954712669 3633 6811515 YHR007C ERG11 SGTC_1116 jasmonic acid  1.58368 µM -0.661118570460895 0.254702287650454 no 2524 0.254268138424042 3654 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2597 laccaic acid a 100 µM -0.661478821831069 0.254591797019876 no 2525 0.254152645932534 3583 5491415 A textile dye. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.663810916931461 0.253877141295017 no 2526 0.253405668812532 3604 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1346 1488-2224 62.4 µM -0.664035761357503 0.253808294844401 no 2527 0.253333711498055 3620 3722427 SGTC_2457 5731572 11.68 µM -0.664556155847912 0.253648989765052 no 2528 0.253167210041153 3650 2865357 SGTC_2289 7946404 165.07 µM -0.667618392609327 0.252712631343412 no 2529 0.252188607068329 3669 1246120 YPR165W RHO1 SGTC_3041 9091929 49.47 µM -0.667968075721621 0.252605822567835 no 2530 0.252076985431105 3680 25236887 SGTC_1976 st070609 63.5 µM -0.66806365259989 0.252576633276743 no 2531 0.252046481065715 3573 682556 SGTC_1396 3511-0007 98.6 µM -0.669390433769379 0.252171616356178 no 2532 0.251623226159949 3579 X1396 SGTC_729 4092-0585 94.1 µM -0.669719338170869 0.252071267088624 no 2533 0.251518360853892 3611 2169061 SGTC_1786 berberine 21.6 µM -0.674490759476595 0.250617871543686 no 2534 0.249999679274407 3617 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2929 9013348 24.6 µM -0.674495169387833 0.250616530321959 no 2535 0.249998277910966 3636 2995952 SGTC_2377 9073351 62.6 µM -0.674518712703459 0.250609369968606 no 2536 0.249990796483566 3599 7337946 YHR072W ERG7 SGTC_2170 morpholine 200 µM -0.674637553061806 0.250573228074808 no 2537 0.249953034053161 3649 121171 Reacts with secondary amines. SGTC_2667 digitoxin 100 µM -0.674913534974349 0.25048930672822 no 2538 0.249865350374577 3601 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3233 9132340 49.47 µM -0.675351336910286 0.250356209259201 no 2539 0.249726287499928 3603 17682950 SGTC_2106 5357045 167.29 µM -0.678441628399121 0.249417787814184 no 2540 0.248745861152469 3651 668842 SGTC_3188 9110789 49.47 µM -0.678750684008619 0.249324040576565 no 2541 0.248647922986526 3662 849217 SGTC_326 k292-0812 17.5 µM -0.679808413841752 0.249003336414263 no 2542 0.2483128892233 3620 3579357 SGTC_1804 st050076 49.1 µM -0.680523027680591 0.248786789486087 no 2543 0.248086673049629 3657 3895976 SGTC_2014 4013930 200 µM -0.682740471666484 0.248115483983095 no 2544 0.247385425550963 3627 64556 SGTC_1743 st037606 46.3785 µM -0.685410147197792 0.247308554276065 no 2545 0.246542571329758 3673 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2108 5365811 200 µM -0.687883525466248 0.246562210771947 no 2546 0.245763065935736 3684 780283 SGTC_2717 st081029 62.2815 µM -0.687993567501059 0.246529033574391 no 2547 0.245728416058866 3637 5292846 SGTC_2949 9072542 2.23 µM -0.690195030918424 0.245865804708834 no 2548 0.245035773905881 3679 16457352 SGTC_1913 st060213 96.1 µM -0.692281823233011 0.245238007701123 no 2549 0.244380181358755 3682 688959 SGTC_57 miconazole 162.5 nM -0.693276771678424 0.244938988053132 no 2550 0.244067938652515 3604 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2507 purpurin 79.67 µM -0.693947093446235 0.244737641667002 no 2551 0.243857694276775 3656 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1914 st062367 72.6 µM -0.694235546214502 0.244651025749198 no 2552 0.243767252034273 3667 978205 SGTC_1508 1080-0625 72.9 µM -0.694646406732423 0.244527682027771 no 2553 0.243638461011446 3611 767111 SGTC_757 1066-0008 322 µM -0.694694666944927 0.244513196112097 no 2554 0.243623335461658 3679 6842497 SGTC_333 3486-0131 40.1 µM -0.69500323942464 0.24442058509219 no 2555 0.243526635724053 3727 6744690 SGTC_1204 4049-0315 18.3 µM -0.695415286297888 0.244296948060328 no 2556 0.24339754175048 3696 588402 SGTC_981 1488-1094 54.9 µM -0.695504814431389 0.244270089088125 no 2557 0.243369497544717 3650 3449522 SGTC_1707 st032323 6.317 µM -0.69907510943353 0.243200278026726 no 2558 0.242252546407542 3609 3132057 YMR211W DML1 SGTC_2584 androsterone 48.74 µM -0.70015931212572 0.242875907259051 no 2559 0.241913909159082 3719 2754130 A steroid. SGTC_1389 3405-0187 19 µM -0.700238495494405 0.242852226427616 no 2560 0.241889187283577 3635 799890 SGTC_3142 9086498 49.47 µM -0.701080473192168 0.242600499179279 no 2561 0.241626397838643 3639 25236367 SGTC_2286 7945697 125 µM -0.702705010586731 0.242115208526668 no 2562 0.241119802227378 3665 1245733 SGTC_2824 7998404 51.95 µM -0.703339365555069 0.241925853549964 no 2563 0.240922141898939 3654 837851 SGTC_1385 3091-4834 14.1 µM -0.706792881004838 0.240896389732928 no 2564 0.239847599623106 3651 4072814 SGTC_958 1222-0007 33 µM -0.708145514049226 0.240493831635498 no 2565 0.239427448916944 3743 7312461 SGTC_1922 5578187 25 µM -0.709325282637378 0.240143019168156 no 2566 0.239061321249039 3715 1350412 SGTC_806 3966-4455 5.86 µM -0.711088684423363 0.239619179735584 no 2567 0.238514640780962 3670 714982 SGTC_2849 9019321 12.99 µM -0.712491227955128 0.239202983256156 no 2568 0.238080320762937 3668 16489627 SGTC_1170 0310-0127 64.8 µM -0.713583641008724 0.238879090007559 no 2569 0.237742338103793 3699 774975 SGTC_739 1486-1183 203 µM -0.714963547071744 0.238470300059545 no 2570 0.237315784198041 3680 4346692 SGTC_2663 amphotericin b 100 µM -0.715695015097619 0.238253761905964 no 2571 0.237089844763439 3694 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3255 9139072 49.47 µM -0.718583136106413 0.237399838010178 no 2572 0.2361989035289 3717 17646060 SGTC_356 1634-0012 32.5 µM -0.719790081747799 0.237043481716822 no 2573 0.2358271262612 3697 735457 SGTC_610 4215-0184 155 µM -0.719986844643905 0.236985414441256 no 2574 0.235766547691387 3742 5605015 SGTC_2416 tofa 880 nM -0.721050704420615 0.236671591116007 no 2575 0.235439159477782 3719 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1008 4106-0037 6 µM -0.721329711016487 0.23658932603955 no 2576 0.235353340580521 3681 2905394 SGTC_2396 5342950 42.78 µM -0.722121987824709 0.236355809067534 no 2577 0.235109740421292 3714 1886677 SGTC_62 0180-0423 3.232 µM -0.723525442929744 0.235942464055393 no 2578 0.234678564242846 3683 30102 YGL099W LSG1 SGTC_511 blebbistatin 171 µM -0.723570996742601 0.235929054244336 no 2579 0.234664576313323 3748 3476986 A myosin inhibitor. SGTC_2694 st077685 81.9 µM -0.724726256437724 0.23558911746505 no 2580 0.234309991960782 3698 2838096 SGTC_1720 st037298 9.481 µM -0.725403923799051 0.235389838698964 no 2581 0.234102133303732 3736 597396 SGTC_73 0327-0325 16.231 µM -0.726056546904973 0.235198012566596 no 2582 0.233902052948779 3723 53298 SGTC_1360 1598-0022 39.8 µM -0.728605998236987 0.234449477823433 no 2583 0.233121354161071 3775 761525 SGTC_2587 piperic acid 92.2 µM -0.728825856033264 0.234384988001684 no 2584 0.233054096631815 3720 5370536 SGTC_2441 5730946 39.09 µM -0.729688672340516 0.234131997155094 no 2585 0.23279025337878 3763 1774275 SGTC_863 0466-0191 129 µM -0.729910874648169 0.234066868557315 no 2586 0.232722332337439 3729 765160 YPR165W RHO1 SGTC_2764 methyldopa 94.69 µM -0.730823478721587 0.233799485038053 no 2587 0.232443490291969 3731 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_668 1682-0499 62.6 µM -0.730906123144143 0.233775279442156 no 2588 0.232418247841307 3751 682214 SGTC_317 4495-0002 170 µM -0.730945609837169 0.233763714736661 no 2589 0.232406187784697 3738 15991618 SGTC_121 0557-0495 61.343 µM -0.732019149093828 0.233449422362458 no 2590 0.232078439989926 3845 3104427 SGTC_1565 sinapyl alcohol 95.1 µM -0.732192957305653 0.233398559837631 no 2591 0.232025401159753 3724 5280507 A phenol propionate derived from cinnamic acid. SGTC_1861 st057647 17.4 µM -0.732785045144502 0.233225339824915 no 2592 0.231844771945179 3753 688668 SGTC_565 1418-0001 44.5 µM -0.73304930080859 0.233148052761802 no 2593 0.231764180320388 3758 2862145 SGTC_2622 2-methoxyxanthone 59.94 µM -0.73408436461063 0.232845463790424 no 2594 0.231448661085833 3747 71034 A hepatoprotective. SGTC_1213 1315-0166 115 µM -0.734320998778583 0.232776317174077 no 2595 0.231376561375244 3768 768401 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.734615009377879 0.232690420550392 no 2596 0.231286997177683 3788 6728940 SGTC_503 tyrphostin 8 294 µM -0.735041673780316 0.232565799813525 no 2597 0.231157057168132 3693 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3334 9142812 21.919 µM -0.735148993081545 0.232534459683299 no 2598 0.23112437964726 3787 45283678 SGTC_2670 beta-carotene 100 µM -0.738283689810271 0.231620080441258 no 2599 0.230171037837134 3662 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1282 0886-0010 32.4 µM -0.73843012119885 0.231577416003361 no 2600 0.230126558133463 3803 2836211 YNL267W PIK1 SGTC_997 3996-0078 137 µM -0.738917310267399 0.231435499505588 no 2601 0.229978605184325 3791 735687 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.740047355096405 0.231106508109216 no 2602 0.229635630387743 3752 5377381 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.740231731090345 0.231052855266481 no 2603 0.229579698463514 3789 6710655 SGTC_3145 9085516 49.47 µM -0.74124760748545 0.230757363097069 no 2604 0.229271661193887 3783 25236195 SGTC_1701 st028638 40.4 µM -0.741609363247813 0.230652188691481 no 2605 0.229162024440502 3713 3490878 SGTC_1724 st037281 8.293 µM -0.741812219315812 0.230593223422507 no 2606 0.229100558038292 3760 574124 YDL195W SEC31 SGTC_397 arbidol 50 µM -0.741838599944229 0.230585555841751 no 2607 0.229092565255638 3805 131410 A RNA synthesis inhibitor. SGTC_3328 9140624 29.0385 µM -0.742287437850637 0.230455122070057 no 2608 0.228956600661673 3741 4904392 SGTC_3038 9091290 49.47 µM -0.743358129684529 0.23014414210495 no 2609 0.228632443361093 3752 25236843 SGTC_2878 9043973 25.97 µM -0.743496442870121 0.230103986489725 no 2610 0.228590587159337 3817 6465167 SGTC_2440 5628896 157.78 µM -0.74675924461604 0.229157855096038 no 2611 0.227604450391987 3784 5522048 SGTC_271 rotenone 740 µM -0.747605438412332 0.22891283670712 no 2612 0.22734909171459 3764 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2581 avocatin a 64 µM -0.748239097495557 0.228729454799698 no 2613 0.227157976075297 3772 6710728 A skin care supplement. SGTC_1642 st009582 77.7 µM -0.749248168458391 0.228437598447658 no 2614 0.226853820819183 3734 6739311 SGTC_3148 9097893 49.47 µM -0.749304706691608 0.228421251932635 no 2615 0.226836785803356 3732 17174100 SGTC_2833 9001315 45.46 µM -0.750349601584905 0.228119266918646 no 2616 0.226522088056275 3759 2989378 SGTC_2552 juarezic acid 87.02 µM -0.750858561048667 0.227972253919496 no 2617 0.226368890762416 3796 1549512 SGTC_1271 0832-2808 169 µM -0.751968486658717 0.227651836697108 no 2618 0.226035005109901 3798 3663794 SGTC_2792 7535235 81.82 µM -0.753673137903571 0.227160226059344 no 2619 0.225522757742942 3768 1281891 SGTC_3322 9139058 2.11 µM -0.753716455191097 0.2271477414289 no 2620 0.225509749472423 3870 4908926 YPR165W RHO1 SGTC_778 3456-2434 196 µM -0.754476387215184 0.226928781622871 no 2621 0.22528160941268 3802 5539063 SGTC_1450 4112-4260 37.6 µM -0.754798555828379 0.226835990872833 no 2622 0.225184930272709 3732 1633175 SGTC_3299 9121982 43.1275 µM -0.756084109570847 0.226465939884663 no 2623 0.224799384290167 3816 17594604 YPL160W CDC60 SGTC_3110 9122132 49.47 µM -0.757549242510763 0.226044612353606 no 2624 0.224360438048463 3896 918317 SGTC_598 3937-0236 20.2 µM -0.75845331306526 0.225784850456863 no 2625 0.224089826095158 3836 1379313 SGTC_1872 amphotericin b 148 nM -0.760655410432584 0.22515284027108 no 2626 0.223431457136864 3791 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_815 1582-0027 36.9 µM -0.761868193660446 0.224805195363052 no 2627 0.2230693374221 3812 3128206 SGTC_1353 1498-1206 8.11 µM -0.762499183505208 0.224624442250185 no 2628 0.222881065136852 3820 6756808 SGTC_1151 3909-8316 15.3 µM -0.764893569482152 0.223939297813723 no 2629 0.222167461705745 3816 800431 SGTC_3000 9075062 71.4286 µM -0.765147988718168 0.22386656657495 no 2630 0.222091713367157 3756 17057871 SGTC_986 1493-0483 84 µM -0.76979128545074 0.22254154027499 no 2631 0.220711854957341 3707 40079 SGTC_410 α-linolenic acid 100 µM -0.771737554242212 0.221987479438522 no 2632 0.220134941720602 3876 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_522 1273-0010 11.6 µM -0.772806834780458 0.221683413814178 no 2633 0.219818353929714 3879 5705015 SGTC_2822 7994718 71.43 µM -0.773400854563986 0.221514598441613 no 2634 0.219642592193215 3752 1018011 SGTC_3250 9135583 49.47 µM -0.774714456967968 0.221141544854915 no 2635 0.219254203206878 3824 7699353 SGTC_1875 nocodazole 6 µM -0.775543516322234 0.220906283134816 no 2636 0.21900928097668 3762 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2927 9011802 47.9 µM -0.776521853775671 0.220628845241469 no 2637 0.21872046124094 3802 43912568 SGTC_2172 5754775 163.918 µM -0.777052460847215 0.220478458693335 no 2638 0.218563909888412 3777 2263357 SGTC_2570 licareol 100 µM -0.777862051152545 0.220249114955441 no 2639 0.218325171131363 3824 443158 SGTC_2916 7875993 68.79 µM -0.778081835022461 0.220186877384229 no 2640 0.218260385363474 3743 1299250 SGTC_2851 9015922 71.43 µM -0.779197997124437 0.219870962503257 no 2641 0.217931544882814 3789 2996893 SGTC_2915 7971052 15.16 µM -0.781628484580452 0.219183945985778 no 2642 0.217216470855015 3645 5741558 SGTC_2215 7188065 200 µM -0.782516949518228 0.218933115374978 no 2643 0.216955414116878 3794 940217 SGTC_1263 0774-1208 64.8 µM -0.783794527611189 0.218572720281427 no 2644 0.216580342706767 3804 906585 SGTC_1310 1188-0297 994 nM -0.784280837795111 0.218435625670329 no 2645 0.216437670380263 3729 1588352 SGTC_2882 9058044 58.44 µM -0.785908902982818 0.217977022056452 no 2646 0.215960429175224 3781 18076804 SGTC_1955 wogonin 32.4 µM -0.788576048029055 0.217226924843105 no 2647 0.215179917339042 3890 5281703 A flavanone. SGTC_1209 2323-2347 50.3 µM -0.789471086316235 0.216975542359703 no 2648 0.214918361222379 3766 5412760 SGTC_2972 9093619 59.92 µM -0.790603997568643 0.216657591561797 no 2649 0.214587556672878 3821 25236256 SGTC_246 cycloheximide 667 µM -0.791569973641192 0.216386703988662 no 2650 0.214305730293001 3698 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2967 9089538 49.85 µM -0.79220951471866 0.216207466116525 no 2651 0.214119260803664 3870 728216 SGTC_245 methotrexate 289.6 µM -0.792461878061421 0.216136762391643 no 2652 0.214045705803838 3819 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_902 1120-0002 2.07 µM -0.793042972672383 0.21597401013995 no 2653 0.213876393181435 3806 3280475 SGTC_1799 st045822 46.1415 µM -0.794660445472569 0.215521364431376 no 2654 0.213405523500999 3781 3674992 SGTC_616 4092-0450 108 µM -0.796072046979178 0.215126781292464 no 2655 0.212995080173307 3869 787165 SGTC_1730 st033808 45.1 µM -0.796723625803113 0.214944787869703 no 2656 0.212805779790383 3797 1045166 SGTC_3003 9075612 71.4286 µM -0.796773404956489 0.214930887660071 no 2657 0.212791321707057 3854 6501993 SGTC_2490 carminic acid 95.39 µM -0.79720239853726 0.214811118175569 no 2658 0.212666746630114 3740 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2285 7945142 200 µM -0.797993998489513 0.214590215476434 no 2659 0.212436986427532 3870 2970608 SGTC_2812 7970281 58.44 µM -0.800058270067259 0.214014784462252 no 2660 0.211838518630584 3865 2233435 SGTC_3024 9090631 49.47 µM -0.801284567923783 0.213673370522371 no 2661 0.211483461353431 3763 25236383 SGTC_3104 9120930 49.47 µM -0.805678441862157 0.212452678844609 no 2662 0.210214141509054 3867 17014836 SGTC_2869 9037858 32.47 µM -0.806334540715076 0.212270753855585 no 2663 0.210024989741354 3781 27187042 SGTC_113 0099-0221 2.5 µM -0.808124523798473 0.211774885470913 no 2664 0.209509450661813 3814 89219 SGTC_2330 7979373 200 µM -0.808170914002512 0.211762043285752 no 2665 0.209496099566652 3803 1863007 SGTC_1594 piperine 70.1 µM -0.809346204179463 0.211436840139234 no 2666 0.209158018199195 3820 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_299 1273-0059 1.44 µM -0.810895239961698 0.211008668548527 no 2667 0.208712917039881 3768 2848077 SGTC_3203 9113543 49.47 µM -0.812131675331119 0.210667268434505 no 2668 0.208358039697375 3949 17018012 SGTC_693 4161-2696 114 µM -0.814508149936797 0.210011995536595 no 2669 0.207676952625112 3887 805759 SGTC_1943 st076331 65.2 µM -0.815470991901666 0.209746849339801 no 2670 0.207401381229373 3881 24208415 SGTC_1750 st081859 2.357 µM -0.817330401553325 0.209235364888486 no 2671 0.206869818776096 3835 5291695 SGTC_2677 mitomycin C 100 µM -0.81772406684874 0.20912717010762 no 2672 0.206757382444557 3872 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1016 4226-1401 38 µM -0.817809274494879 0.20910375601652 no 2673 0.206733050709297 3834 2901613 SGTC_1229 0139-0193 12.2 µM -0.81937032500421 0.208675070366502 no 2674 0.206287580185593 3884 3090752 SGTC_380 3970-0968 6 µM -0.821136407160035 0.208190705328784 no 2675 0.20578428717178 3788 2891601 SGTC_2450 5739737 12.93 µM -0.822273856180022 0.207879100522607 no 2676 0.205460526323775 3907 2262825 SGTC_1629 st005085 44.9 µM -0.822538072439572 0.207806757764972 no 2677 0.205385363735293 3850 24207091 SGTC_780 0109-0199 192 µM -0.823196314145065 0.207626595001646 no 2678 0.205198182288613 3933 610414 SGTC_822 1487-0950 154 µM -0.824244180692895 0.207339981207475 no 2679 0.204900414054511 3850 1958375 SGTC_1938 st074717 56.4 µM -0.824897448830374 0.207161416912789 no 2680 0.204714907425775 3713 17250979 SGTC_1275 0867-0008 21.1 µM -0.825494944784587 0.206998177057178 no 2681 0.204545325763688 3835 3422836 SGTC_577 r071-0003 38.6 µM -0.827732395355449 0.206387567263845 no 2682 0.203911034230909 3907 4568517 YMR134W ERG29 SGTC_33 0986-0033 35.816 µM -0.829996189149464 0.205770855835259 no 2683 0.203270469136191 3781 2848082 SGTC_991 3996-0057 64.7 µM -0.830495126030125 0.205635080737846 no 2684 0.203129451193742 3930 715343 SGTC_2260 7964312 200 µM -0.831363115819948 0.205399002482015 no 2685 0.20288426453159 3924 231951 SGTC_3329 9141233 27.5565 µM -0.831416781908055 0.205384411517092 no 2686 0.202869110931418 3860 4909101 YNL103W MET4 SGTC_3090 9117696 49.47 µM -0.832576875502114 0.205069150834365 no 2687 0.20254170261912 3826 7923821 SGTC_556 4058-0063 51.5 µM -0.838518052135737 0.203459122949153 no 2688 0.200869906713963 3942 6615692 SGTC_1423 4048-0112 5.59 µM -0.841346134810629 0.202695383787177 no 2689 0.200077026093361 3924 X1423 SGTC_2269 7935389 174.42 µM -0.84447216748444 0.201853178158161 no 2690 0.199202804927721 3849 97605 SGTC_558 k064-0027 21.3 µM -0.845157809098731 0.201668735365526 no 2691 0.199011367627306 3927 5088526 SGTC_1993 st073995 70.8 µM -0.845225152758066 0.201650624856693 no 2692 0.198992570653287 3886 3098394 SGTC_1964 st076914 61 µM -0.846123854779126 0.201409033138557 no 2693 0.198741827205114 3929 24208661 SGTC_3218 9131285 49.47 µM -0.846304097346703 0.201360600694836 no 2694 0.198691561353052 3854 17156417 SGTC_287 k060-0039 29.6 µM -0.848336463387994 0.200814972951887 no 2695 0.198125308044103 3924 5861974 SGTC_2035 5154463 94.595 µM -0.849489685059659 0.200505763390271 no 2696 0.197804433728672 3925 2769623 SGTC_187 1488-2104 32.728 µM -0.851346146202898 0.200008597581271 no 2697 0.197288548944162 3906 2852859 SGTC_1561 5-methoxyflavone 52.9 µM -0.854758406535045 0.199096719500431 no 2698 0.196342454455596 3845 94525 SGTC_3058 9093861 49.47 µM -0.855737969448171 0.198835408670276 no 2699 0.196071366537392 3901 17217477 SGTC_3236 9132701 49.47 µM -0.856468789766349 0.198640587810105 no 2700 0.19586926452347 3916 24282524 SGTC_2844 9010103 25.97 µM -0.857439179183276 0.198382081004343 no 2701 0.195601107198351 3980 2480525 SGTC_1792 st045773 43.6 µM -0.85913902954692 0.197929739061572 no 2702 0.195131908263547 3831 2919270 SGTC_1037 k284-1091 78.7 µM -0.859734749149343 0.197771361496349 no 2703 0.194967637564639 3872 3334711 SGTC_891 0929-0073 133 µM -0.859880317107297 0.197732672553838 no 2704 0.194927509738509 3984 5603632 SGTC_3130 9127414 49.47 µM -0.861015349232461 0.19743116146103 no 2705 0.194614794670629 3911 1494646 SGTC_2241 6772625 37.8075 µM -0.861746603745652 0.197237057604742 no 2706 0.194413486999849 3815 2285411 SGTC_1442 4112-3290 3 µM -0.86174758436409 0.197236797387379 no 2707 0.194413217129712 3897 704353 SGTC_1392 3455-1037 33.9 µM -0.862107416159015 0.197141326276616 no 2708 0.19431420536847 3928 981132 SGTC_2355 9061122 103.12 µM -0.86433841429301 0.196550018902813 no 2709 0.193701006763932 3948 5302957 SGTC_2199 6590217 200 µM -0.865035260964224 0.196365545998083 no 2710 0.193509717796973 3827 703109 SGTC_1014 4130-3005 69.3 µM -0.865417697784361 0.196264349935256 no 2711 0.193404785379642 3940 743608 SGTC_1355 1499-0035 1.68 µM -0.86594901434752 0.196123811503785 no 2712 0.193259061202814 3908 1548538 SGTC_767 0929-0023 86 µM -0.867440288621913 0.195729681036258 no 2713 0.192850407589726 3947 1204563 SGTC_3016 9080866 49.47 µM -0.869799208572848 0.195107222149904 no 2714 0.192205072034998 3929 17066299 SGTC_590 k048-0076 22.4 µM -0.871022300279647 0.194784953618632 no 2715 0.191870988479127 3946 6832814 SGTC_1321 1326-2144 215 µM -0.871993533609179 0.19452927723108 no 2716 0.191605952610457 3943 3513030 SGTC_2458 5808907 16.39 µM -0.872297288617577 0.194449355919349 no 2717 0.191523108211258 4058 2731747 SGTC_609 0986-0026 86.3 µM -0.872901375803262 0.194290473292451 no 2718 0.191358418164869 3891 2848610 SGTC_2097 5376186 200 µM -0.876854053009434 0.19325282095684 no 2719 0.190282957678211 3887 742755 SGTC_1822 st052468 42 µM -0.877561678567176 0.193067413494318 no 2720 0.190090816631113 3944 2873678 SGTC_2155 5570423 76 µM -0.877751911572003 0.193017588404787 no 2721 0.190039183145733 3886 797402 SGTC_1334 1486-0610 236 µM -0.879009005304415 0.192688532717706 no 2722 0.189698196569362 4020 3742339 SGTC_2887 9044784 58.44 µM -0.879358114999907 0.192597210942201 no 2723 0.189603567398748 3929 6465546 SGTC_1454 4239-0054 42.6 µM -0.881345947422687 0.192077728583981 no 2724 0.189065302040444 4072 1340767 SGTC_583 1488-1091 88.9 µM -0.883151284698138 0.191606681560126 no 2725 0.18857726913345 4064 4303273 SGTC_2754 granisetron 64.02 µM -0.885049255461549 0.191112228391479 no 2726 0.188065033180033 3943 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1641 st009299 47.1 µM -0.885208851540099 0.191070686632076 no 2727 0.188021999594914 3868 4046054 SGTC_1287 0971-0001 34.6 µM -0.886059784081588 0.190849288241261 no 2728 0.187792656240798 3936 4665869 SGTC_2487 5918373 44.05 µM -0.886163957889365 0.190822194779945 no 2729 0.187764591189519 3986 2876279 SGTC_845 0330-0138 4.51 µM -0.886966189682838 0.19061362989062 no 2730 0.187548551912019 3900 9039800 SGTC_2104 5389443 200 µM -0.888472946513515 0.190222280405008 no 2731 0.187143200953261 4021 2244536 SGTC_1531 st059297 52.4 µM -0.889502701903065 0.189955106533894 no 2732 0.186866485883191 3966 7566702 SGTC_2922 7999257 32.47 µM -0.889664023313445 0.189913272002883 no 2733 0.18682315867078 3920 2988377 SGTC_1560 lithocholic acid 53.1 µM -0.890558021750445 0.189681539341202 no 2734 0.186583164011399 3814 9903 A bile acid which acts as a detergent. SGTC_142 0335-0849 62.6745 µM -0.893525054531861 0.188913704281022 no 2735 0.185788030525071 3966 3889043 YPR107C YTH1 SGTC_2486 5283202 22.39 µM -0.898600414052909 0.187604705070763 no 2736 0.184432769048454 4021 1377751 SGTC_3200 9114385 49.47 µM -0.900577781933937 0.187096237636223 no 2737 0.183906426070596 4032 17018030 YLR208W SEC13 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.901047081942516 0.18697568543298 no 2738 0.183781643574885 3755 4000243 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.906179404585779 0.185660450158983 no 2739 0.182420451103986 4001 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1247 0448-0043 5.84 µM -0.907452349496323 0.18533512931983 no 2740 0.182083818459629 4025 3089013 YGL099W LSG1 SGTC_3044 9093193 49.47 µM -0.908960376212667 0.184950187984005 no 2741 0.1816855209187 4015 25236277 SGTC_961 1252-1571 372 µM -0.909986720776836 0.184688485948998 no 2742 0.181414756485311 3976 6813498 SGTC_546 peri-Naphthalide 147 µM -0.910916615609419 0.184451576005588 no 2743 0.181169655125848 3885 223824 A penicillin ester. SGTC_34 0469-0683 81.75 µM -0.911441565017546 0.184317917803613 no 2744 0.181031380784847 3955 3690923 SGTC_1620 st003704 16.5 µM -0.911595756636494 0.184278670283703 no 2745 0.180990778496026 3900 2834414 SGTC_425 3825-7017 13.1 µM -0.91492202712057 0.18343327684793 no 2746 0.180116282715816 4083 3397440 SGTC_2553 4-methylesculetin 85.09 µM -0.915346442507589 0.183325583088453 no 2747 0.180004892578041 4017 5319502 SGTC_508 roscovitine 141 µM -0.915983285603533 0.183164060599567 no 2748 0.179837830795311 4049 160355 A CDKinase inhibitor. SGTC_1909 st060837 51.5 µM -0.917651210544381 0.182741445718094 no 2749 0.179400749111307 3997 678937 SGTC_1827 berberine 7.24 µM -0.919559363720814 0.182258709623249 no 2750 0.178901535173843 3940 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1895 st058434 18.3 µM -0.919582570552981 0.182252843528278 no 2751 0.178895469153213 4008 5393175 SGTC_1343 1487-0095 224 µM -0.919884823005657 0.182176452597588 no 2752 0.178816475379634 4001 4560101 YGL055W OLE1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.920587996193479 0.181998810884388 no 2753 0.178632785820207 3948 16623 A steroid. SGTC_2944 9067346 25.62 µM -0.920913603225728 0.181916589911742 no 2754 0.178547767932305 3961 6473075 SGTC_2711 st079103 59.1 µM -0.923437077941722 0.181280160162149 no 2755 0.177889738385666 3960 54693780 SGTC_66 0109-0187 42.4 µM -0.925273034609389 0.180818002394395 no 2756 0.177411950786402 3921 759417 SGTC_1494 4358-1428 177 µM -0.925986379338841 0.180638634486213 no 2757 0.177226529384723 4032 1564571 SGTC_1126 isoteolin 1.0172 µM -0.929059879069163 0.179867090930317 no 2758 0.176429027655622 3947 133323 SGTC_2001 4023502 57.655 µM -0.931575428695192 0.179237152834775 no 2759 0.175777993204837 4037 108941 YCR052W RSC6 SGTC_2808 7946468 45.46 µM -0.931771324213589 0.179188155435571 no 2760 0.175727358597899 4025 2970879 SGTC_2248 tofa 1.1 µM -0.934028146454392 0.178624286656103 no 2761 0.175144687136865 3948 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1581 himbacine 57.9 µM -0.934674239870091 0.178463065673113 no 2762 0.174978103169936 4009 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2041 5107442 45.335 µM -0.935502608190259 0.178256495417252 no 2763 0.174764669913104 4058 793005 SGTC_910 3454-3003 490 µM -0.935770362037445 0.178189757862601 no 2764 0.174695717146509 3949 820824 SGTC_3014 9081533 49.47 µM -0.936378014127757 0.178038359222202 no 2765 0.17453929686132 4057 21367265 SGTC_1622 st003707 19.4 µM -0.936461175917044 0.178017645483203 no 2766 0.17451789648265 4037 10140899 SGTC_3156 9099931 49.47 µM -0.938936369955298 0.177401825864778 no 2767 0.173881707276643 4032 18111053 SGTC_2370 9071495 200 µM -0.939601215668372 0.17723664399383 no 2768 0.173711076241627 4026 21791103 SGTC_2907 7721985 69.9 µM -0.939675459979017 0.177218203919504 no 2769 0.173692028233911 4056 3267881 SGTC_901 1112-0062 60.1 µM -0.939767819095759 0.177195266358451 no 2770 0.173668334573762 4017 1908457 SGTC_1648 st011736 69.8 µM -0.940241700099367 0.177077606610757 no 2771 0.173546798243254 4021 2855514 SGTC_1373 2887-0003 58.5 µM -0.941344738455388 0.176803924813016 no 2772 0.17326411151614 3999 776948 SGTC_3113 9123498 49.47 µM -0.941769917113731 0.176698502490455 no 2773 0.173155225041941 4104 8897275 SGTC_2313 7726885 200 µM -0.941771021853513 0.17669822862389 no 2774 0.173154942179487 4072 726423 SGTC_11 0438-0307 1.3 µM -0.942183910195016 0.176595891809834 no 2775 0.173049245033695 4000 4011476 SGTC_722 3534-0461 190 µM -0.942187255056458 0.176595062919251 no 2776 0.173048388935417 4073 658262 SGTC_2124 5246320 200 µM -0.942481816193258 0.17652207733142 no 2777 0.172973008267033 4040 579342 SGTC_1893 st059353 36.1 µM -0.943057941545853 0.176379381657842 no 2778 0.172825633436927 4029 3112488 SGTC_2558 carylophyllene oxide 100 µM -0.944024207571242 0.176140219196863 no 2779 0.17257863901138 4130 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2456 5770359 74.46 µM -0.944334478786916 0.176063466899813 no 2780 0.17249937604963 4051 3118787 SGTC_678 1218-2179 85.9 µM -0.944940177978947 0.175913695124347 no 2781 0.172344708943625 4003 6820081 YOR116C RPO31 SGTC_3176 9106582 49.47 µM -0.947122167573382 0.175374821752028 no 2782 0.171788265045527 3970 17018027 SGTC_929 2805-0021 398 µM -0.947348632152856 0.175318953110282 no 2783 0.1717305785808 4098 3098024 SGTC_110 0850-0284 111.64 µM -0.949068289485484 0.174895083202882 no 2784 0.171292940558091 3824 3906265 SGTC_2087 5276107 200 µM -0.949634660391084 0.174755623702546 no 2785 0.171148960251877 3987 144405 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.952129913557377 0.174142049651716 no 2786 0.170515549979006 4051 165521 SGTC_766 1391-0721 126 µM -0.953421929335724 0.17382488619096 no 2787 0.170188167424439 4089 1020919 YIL115C NUP159 SGTC_1495 4469-0029 237 µM -0.958315624682573 0.172626917837108 no 2788 0.16895181366159 4048 793680 SGTC_925 2064-1272 59.6 µM -0.96113814366539 0.171938369371414 no 2789 0.168241356525834 4023 6815817 SGTC_2790 5423970 71.43 µM -0.962215671327044 0.171675971551225 no 2790 0.167970639329598 4125 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_737 1950-0117 57.9 µM -0.962705414835467 0.171556794594471 no 2791 0.167847689286472 4005 5393513 SGTC_1210 3013-0140 750 nM -0.964043734747355 0.171231389943542 no 2792 0.167511999833681 4079 905973 SGTC_552 k242-0005 476 µM -0.968780226246564 0.170082912231696 no 2793 0.166327427252398 4135 4088318 SGTC_1489 4065-0444 182 µM -0.969209509046401 0.169979066717213 no 2794 0.166220333799121 4026 2877968 SGTC_667 1498-1044 59 µM -0.970554254082652 0.16965402974968 no 2795 0.165885147752682 4068 6739982 SGTC_2690 usnic acid 100 µM -0.970719832758154 0.1696140354805 no 2796 0.165843906468651 4089 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_868 0527-0199 213 µM -0.972345048428176 0.169221798075023 no 2797 0.165439459904211 4007 2849450 SGTC_1426 4048-4480 71.7 µM -0.97258036957286 0.169165052835247 no 2798 0.165380951479219 4047 14224343 SGTC_2257 7960413 200 µM -0.97275284777621 0.169123469275648 no 2799 0.165338076339167 4054 2974689 YIL048W NEO1 SGTC_2716 st080858 38.6235 µM -0.972842810271667 0.169101782410726 no 2800 0.165315716051241 4033 5296050 SGTC_183 3914-0051 30.55 µM -0.97309199046718 0.169041722955976 no 2801 0.165253792226462 4096 1596232 SGTC_1610 st001799 48.1 µM -0.974736378123488 0.168645722726193 no 2802 0.164845521544625 3957 621897 SGTC_337 1315-0038 354 µM -0.97627027378719 0.168276869070542 no 2803 0.164465273398259 4013 1626437 SGTC_2476 5806916 10.51 µM -0.978183584884115 0.167817505856336 no 2804 0.163991766821131 3930 2870194 SGTC_1324 1418-0026 34.4 µM -0.979019361734426 0.167617099388649 no 2805 0.163785206455794 4109 1372513 SGTC_1954 st077032 68.9 µM -0.980870659081198 0.167173735819475 no 2806 0.163328264080161 4048 698907 SGTC_828 2074-0507 139 µM -0.981835232161428 0.166943031957633 no 2807 0.163090513946655 4152 X828 SGTC_1960 st011366 51.8 µM -0.983235276638628 0.166608538791896 no 2808 0.162745828247305 4083 3972846 SGTC_1756 st041558 35.5 µM -0.984367876193337 0.166338259249836 no 2809 0.162467333428651 4171 3955792 SGTC_3251 9135047 49.47 µM -0.985801555185642 0.165996537457195 no 2810 0.162115251233575 4089 17682963 SGTC_100 0086-0128 49.5915 µM -0.986734194421783 0.16577448374666 no 2811 0.161886481089767 4133 93297 SGTC_599 1935-0052 86.5 µM -0.989188636156714 0.165191019567805 no 2812 0.161285428642802 4065 9557311 SGTC_1222 0366-0074 1.18 µM -0.990612051893516 0.164853258166727 no 2813 0.160937525251464 4091 286520 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.991165849152251 0.164721968924713 no 2814 0.160802301655974 4146 1273210 SGTC_3095 9117207 49.47 µM -0.991797972587192 0.164572193632054 no 2815 0.160648043434621 4063 17015229 SGTC_2420 aureobasidin a 50 nM -0.99180109560413 0.164571453883744 no 2816 0.160647281559172 4206 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2816 7982706 58.44 µM -0.992419318017154 0.164425058116461 no 2817 0.160496509610779 4114 2981853 SGTC_785 1270-0111 65.3 µM -0.992554596988838 0.164393035163459 no 2818 0.160463530136067 4013 6741994 SGTC_2744 captopril 92.04 µM -0.994021738713782 0.164045996190961 no 2819 0.160106142089883 4110 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_519 k048-0011 62.8 µM -0.994742061135432 0.163875784581109 no 2820 0.159930865944346 4122 6836379 SGTC_1645 Cervolide 78 µM -0.995197649218689 0.163768188671812 no 2821 0.159820072452423 4057 23173 A fragrance. SGTC_334 1502-1024 68.5 µM -0.995602742261372 0.163672556661122 no 2822 0.159721600922741 4110 3296216 SGTC_1071 trifluoperazine 6.31 µM -0.998485684050707 0.162993015884241 no 2823 0.159021951496674 4163 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1920 st075728 45.7 µM -0.999362612537007 0.162786678610305 no 2824 0.158809532189523 4053 3400306 SGTC_1801 st050089 28.441 µM -0.999442265315835 0.162767945094221 no 2825 0.158790247031744 4121 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_203 k066-0004 30.888 µM -1.00083091720706 0.162441573734656 no 2826 0.158454279823964 4170 6795412 SGTC_2814 7977482 42.97 µM -1.00146036297523 0.162293777053787 no 2827 0.158302146864833 4153 6456762 SGTC_884 0851-0618 334 µM -1.0031507776546 0.161897293496901 no 2828 0.157894059047652 4112 9642473 SGTC_2634 4'-methoxyflavone 100 µM -1.00382968544093 0.161738234729338 no 2829 0.157730356596977 4099 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1395 3486-0190 4.35 µM -1.01003672723319 0.160288733901601 no 2830 0.156238847135407 4079 6748079 SGTC_1647 st011722 22.4 µM -1.01069874232708 0.160134639284203 no 2831 0.156080319593604 4078 2854783 SGTC_1794 st048918 76.9 µM -1.01228818530125 0.15976506651077 no 2832 0.155700141101429 4021 672303 SGTC_1100 amiodarone 5.07 µM -1.01494410455729 0.159148765978974 no 2833 0.155066236330375 4196 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2642 cholecalciferol 100 µM -1.01508224988517 0.1591167523076 no 2834 0.15503331101509 4101 9821465 A vitamin D precursor, similar to steriods. SGTC_218 alverine citrate 93.75 µM -1.01514270646787 0.159102743481816 no 2835 0.155018903351465 4149 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2375 9072683 200 µM -1.01807294000988 0.158424726830342 no 2836 0.154321646988933 4175 16798029 SGTC_2278 7948257 134.34 µM -1.01849539157151 0.158327133771973 no 2837 0.154221294895221 4105 1247028 SGTC_1927 st060202 13.8 µM -1.02305512744078 0.157276272981396 no 2838 0.153140890796759 3986 688887 SGTC_664 1222-0054 14.9 µM -1.02860583755183 0.156003229961517 no 2839 0.151832466858849 4096 6813991 SGTC_2658 polymyxin b sulfate 77.05 µM -1.02897393940675 0.155919047421026 no 2840 0.15174596059469 4146 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3087 9117406 49.47 µM -1.02967705910902 0.155758331683809 no 2841 0.151580814066884 4142 42546093 SGTC_2271 7849410 118.62 µM -1.03057160664627 0.155554018238658 no 2842 0.151370878335319 4058 972430 SGTC_3106 9121286 49.47 µM -1.0310693030798 0.155440421625809 no 2843 0.15125416084733 4123 15943471 SGTC_804 1595-0054 20.9 µM -1.03172213622558 0.155291498875696 no 2844 0.151101152193648 4059 761523 Stimulates phospholipase C. SGTC_2319 6033012 152.6 µM -1.03261057274215 0.155088982169273 no 2845 0.150893089182464 4087 847246 SGTC_281 1672-3440 14.9 µM -1.0328499259231 0.155034452088721 no 2846 0.150837067668845 4163 6833000 SGTC_998 3996-0085 177 µM -1.03480056554315 0.154590524237023 no 2847 0.150381029382899 4156 715391 SGTC_269 exalamide 29 µM -1.03719099320488 0.154047655808969 no 2848 0.149823427395476 4043 3316 A derivative of salicylamide. SGTC_836 0330-0104 1.35 µM -1.03807802076101 0.153846532225936 no 2849 0.149616866588721 4146 46494820 SGTC_2894 9048625 32.47 µM -1.04227398172526 0.152897501399788 no 2850 0.148642335776901 4133 4092861 SGTC_3280 9140961 49.47 µM -1.04284059034913 0.15276964555197 no 2851 0.148511064312251 4163 4901226 SGTC_42 0133-0086 60.653 µM -1.04340311872501 0.152642780582216 no 2852 0.148380814863933 4015 162923 Model of phenazepam hydroxylation. SGTC_1049 3226-0134 66 µM -1.0456869960039 0.152128424173691 no 2853 0.147852784316666 4180 5702385 SGTC_773 4358-1457 44.6 µM -1.04842157842137 0.151514079352631 no 2854 0.147222208006782 4152 1186886 SGTC_377 3970-0964 33.1 µM -1.0491249006718 0.151356339676778 no 2855 0.147060318508219 4095 16481235 SGTC_1470 k295-0292 231 µM -1.05040991247267 0.151068422010232 no 2856 0.146764845097928 4226 5045612 SGTC_501 nsc-95397 161 µM -1.05231749783537 0.150641684000881 no 2857 0.146326953154358 4180 262093 SGTC_1251 0490-5699 265 µM -1.05520626104483 0.149996980516714 no 2858 0.145665500643952 4206 3883818 SGTC_1997 st073024 93.8 µM -1.05597498998551 0.149825728822209 no 2859 0.145489820652478 4151 686268 SGTC_907 3448-6986 75.5 µM -1.06189682097465 0.148510880391066 no 2860 0.144141264224224 4191 590582 SGTC_962 1254-0300 21.5 µM -1.06331748589665 0.148196595381218 no 2861 0.143818999029618 4131 7340576 SGTC_2350 9023895 38.85 µM -1.06393458705017 0.148060216600839 no 2862 0.143679166673229 4184 2997209 SGTC_2910 7948405 25.97 µM -1.06403569871316 0.148037879028646 no 2863 0.14365626397443 4078 2971328 SGTC_2219 9098279 200 µM -1.06813426340824 0.147134323368782 no 2864 0.142729976081361 4092 902349 SGTC_950 1165-0508 94.1 µM -1.07221441173149 0.146238507628107 no 2865 0.1418118693659 4185 6148369 SGTC_2144 5628481 200 µM -1.07464962803579 0.145705593516437 no 2866 0.141265811901334 4148 2818399 SGTC_1783 st039459 87.517 µM -1.07499813301277 0.145629434843826 no 2867 0.141187782102367 4271 729761 SGTC_2 0422-0095 29 µM -1.07692917112051 0.145207930818728 no 2868 0.140755954854978 4070 6790840 SGTC_2426 5582046 32.21 µM -1.08056270378672 0.144417036483614 no 2869 0.139945840190799 4186 2251934 SGTC_1712 st032288 53.4 µM -1.08266152705911 0.143961520415182 no 2870 0.139479343356574 4050 2883011 SGTC_2695 st077686 51.995 µM -1.083324747144 0.143817780802128 no 2871 0.139332152323086 4198 2876092 SGTC_3135 9127742 49.47 µM -1.08376579587484 0.143722245984534 no 2872 0.139234327177079 4268 3643468 SGTC_2636 apigenin dimethyl ether 100 µM -1.08442531059454 0.143579469529755 no 2873 0.139088133225281 4174 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2282 7944268 200 µM -1.08583817638911 0.143273924577745 no 2874 0.138775296493641 4211 2970414 SGTC_3042 9091578 49.47 µM -1.08596036230302 0.143247521418964 no 2875 0.138748264621362 4148 25236497 SGTC_1159 4092-0538 61.2 µM -1.08883608353715 0.142627055492535 no 2876 0.138113088150045 4213 717301 SGTC_1048 3161-0300 24.5 µM -1.09046157146699 0.142277145106461 no 2877 0.13775493613547 4173 2165101 SGTC_1888 azatryptophan 97.5 µM -1.09400019386901 0.141517414162957 no 2878 0.136977446591756 4230 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2361 9034121 116 µM -1.0949768031064 0.141308224174661 no 2879 0.136763399606476 4192 6496917 SGTC_1004 4084-0029 199 µM -1.09517013341805 0.141266837631526 no 2880 0.136721053829368 4214 716894 YLR208W SEC13 SGTC_278 4092-0821 23.9 µM -1.09684935595572 0.140907709311156 no 2881 0.136353625234423 4183 877900 SGTC_2204 7233102 200 µM -1.09832083969312 0.140593518784927 no 2882 0.136032207549105 4101 2172480 SGTC_3080 9117754 49.47 µM -1.10430916552583 0.139319801924803 no 2883 0.134729524141431 4210 9550191 SGTC_1184 1269-1718 139 µM -1.10680917757337 0.138790379591645 no 2884 0.134188219724494 4254 5403821 SGTC_3037 9091026 49.47 µM -1.10797033692631 0.138544949881264 no 2885 0.1339373133977 4131 25236398 YIL048W NEO1 SGTC_846 0335-0850 148 µM -1.10827547453503 0.138480503234199 no 2886 0.133871431999299 4170 6819598 SGTC_1252 0493-0875 34.8 µM -1.10931023996873 0.138262107521613 no 2887 0.13364818456598 4190 3960963 SGTC_540 1187-0821 17.3 µM -1.10952189413593 0.138217465119223 no 2888 0.133602552388317 4145 847520 SGTC_1226 3909-7979 35.4 µM -1.11151357207293 0.137797858877726 no 2889 0.133173675701437 4193 6615510 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.11252626094887 0.137584839485689 no 2890 0.132955972721752 4236 688798 SGTC_1180 1193-0155 285 µM -1.113192076635 0.137444907504613 no 2891 0.132812972441349 4285 2921347 SGTC_2544 sphondin 68.51 µM -1.1147572781596 0.137116337793277 no 2892 0.132477224210936 4203 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1253 0550-0034 176 µM -1.11560164427915 0.136939310051978 no 2893 0.132296343989868 4235 5969915 SGTC_1393 3470-5649 58.2 µM -1.11904406731145 0.136219196950322 no 2894 0.131560669847253 4190 4108395 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.11927574976304 0.136170825038549 no 2895 0.131511259013452 4222 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3072 9116419 49.47 µM -1.12036986091936 0.135942549462073 no 2896 0.131278091414214 4253 17170162 SGTC_1939 st074455 53.6 µM -1.12047379242819 0.135920878805134 no 2897 0.131255957277925 4222 1644229 SGTC_2198 6589944 200 µM -1.12781020862294 0.134397143904132 no 2898 0.129700040552388 4214 5290268 SGTC_2137 5261020 140 µM -1.12998564342993 0.13394758087873 no 2899 0.129241136986439 4182 763655 SGTC_2160 5660466 132.927 µM -1.13058305798862 0.133824303644773 no 2900 0.129115310811593 4138 2859134 SGTC_1444 4112-3581 28 µM -1.13175940085839 0.133581791853084 no 2901 0.128867800325375 4270 2877249 SGTC_844 0330-0132 15.3 µM -1.13478294124449 0.13295985385914 no 2902 0.128233137713033 4272 2828079 SGTC_1085 doxorubicin 7.67 µM -1.13591735908139 0.132727020815604 no 2903 0.127995576250441 4250 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1113 artemisinin 1.17947 µM -1.13702438893679 0.132500079884284 no 2904 0.127764045114745 4257 2240 An anti-malaria and mitochondrial poison. SGTC_2472 5377652 49.4 µM -1.13797325727602 0.132305774948495 no 2905 0.127565824674851 4297 1610903 SGTC_3107 9121808 49.47 µM -1.13874463315298 0.132147960908622 no 2906 0.127404840397568 4161 662681 SGTC_3183 9108214 49.47 µM -1.13979680824182 0.131932908123767 no 2907 0.127185481891205 4166 4974831 SGTC_2964 9083345 53.42 µM -1.14074863847501 0.131738572765115 no 2908 0.126987269878568 4220 17741579 SGTC_2649 anisomycin 9.56 µM -1.14102016322917 0.131683171731452 no 2909 0.126930766175873 4258 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1640 st009078 66.4 µM -1.14226133329995 0.131430132125999 no 2910 0.126672704268714 4210 690618 SGTC_1982 st072467 71.9 µM -1.14500539878942 0.130871886572019 no 2911 0.126103460487468 4205 3163533 SGTC_2823 7987624 58.44 µM -1.14513773554039 0.130845005808979 no 2912 0.126076052983654 4235 2239440 SGTC_685 1278-0033 54.9 µM -1.14519845498218 0.130832673513529 no 2913 0.126063479119029 4308 3590572 SGTC_1547 harmine 94.2 µM -1.1465090611321 0.13056668138128 no 2914 0.125792290092986 4189 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1136 pergolide 1.05886 µM -1.14858677024692 0.130145769731475 no 2915 0.125363207427843 4199 47811 A dopamine receptor agonist. SGTC_162 k030-0015 37.8 µM -1.14985294517634 0.129889723288019 no 2916 0.12510222211957 4303 1809920 YMR134W ERG29 SGTC_3202 9113761 49.47 µM -1.15004284777774 0.129851351198457 no 2917 0.125063111943077 4212 4798415 SGTC_2650 prasterone 100 µM -1.15180627508288 0.12949540447022 no 2918 0.124700344359816 4226 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1465 k213-0056 144 µM -1.15187675115715 0.129481192979604 no 2919 0.12468586150807 4129 24048857 YMR208W ERG12 SGTC_1654 st012436 41.8 µM -1.15207110170618 0.129442007817315 no 2920 0.124645928510617 4244 4323132 SGTC_1363 1636-0063 10.4 µM -1.15339297174238 0.129175708991382 no 2921 0.124374562467093 4256 6072185 SGTC_850 0388-0143 75.9 µM -1.15407868691781 0.129037717174549 no 2922 0.124233955203888 4221 67273 SGTC_2687 chenodiol 100 µM -1.15551940447913 0.128748123414624 no 2923 0.123938895520455 4320 5702181 A cholesterol synthesis inhibitor. SGTC_3191 9110352 49.47 µM -1.15633487158078 0.128584409118303 no 2924 0.123772104979098 4196 17122424 SGTC_1417 3966-0327 90.4 µM -1.15675748639116 0.128499621249555 no 2925 0.12368572783649 4353 651118 SGTC_1924 st058459 75.1 µM -1.15980785929053 0.127888785494525 no 2926 0.123063521761367 4199 688683 SGTC_2013 4024628 200 µM -1.16158190037134 0.127534463983954 no 2927 0.122702668813014 4296 5230760 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.16355445727618 0.127141295845619 no 2928 0.122302308453637 4266 115019 SGTC_1473 k844-0725 134 µM -1.16437907758728 0.12697718356139 no 2929 0.122135211331939 4297 54682906 SGTC_1514 1189-1591 158 µM -1.16886437656653 0.126087121447795 no 2930 0.121229139056865 4263 767698 YMR146C TIF34 SGTC_172 1112-0046 2.638 µM -1.17427442012946 0.125019352074817 no 2931 0.120142562870993 4246 2802135 YIL048W NEO1 SGTC_996 3970-0799 1.8 µM -1.17500725212531 0.124875201682301 no 2932 0.119995907209051 4260 6615648 YGL040C HEM2 SGTC_2165 5727197 32.143 µM -1.17558080967628 0.124762462121925 no 2933 0.119881213895831 4376 1361712 SGTC_2532 xanthone 78.9 µM -1.17689726651252 0.124503965911425 no 2934 0.119618256625496 4270 7020 An insecticide. SGTC_2990 9074105 71.4286 µM -1.17724528437634 0.124435692607824 no 2935 0.119548809416143 4181 6502001 SGTC_1043 0916-0009 19.3 µM -1.18108012590882 0.123685115924545 no 2936 0.118785447115969 4293 3101130 SGTC_2973 9094665 17.96 µM -1.18116800688927 0.12366795260172 no 2937 0.118767994006235 4280 25237061 YIL048W NEO1 SGTC_280 3448-3607 3.04 µM -1.1817141728857 0.123561322731202 no 2938 0.11865956638125 4226 626179 SGTC_367 0335-0881 7.1 µM -1.18350612222059 0.123211926542131 no 2939 0.118304310806342 4229 23828853 SGTC_1269 0831-0796 3.05 µM -1.18712967134095 0.122507520085882 no 2940 0.117588238123148 4302 927758 SGTC_3066 9117245 49.47 µM -1.18718750663081 0.122496300046648 no 2941 0.117576833853112 4321 17176980 SGTC_1171 0368-0077 21.4 µM -1.1891075391018 0.122124223236492 no 2942 0.117198676026636 4228 3239779 SGTC_1158 4092-0494 91.8 µM -1.19287301031408 0.121396830764771 no 2943 0.116459555438434 4364 1148199 SGTC_3353 9151644 39.2805 µM -1.19529862769402 0.120929879872803 no 2944 0.115985187880322 4299 4909158 SGTC_946 3434-1334 87.4 µM -1.19560453682842 0.120871079769881 no 2945 0.115925460094449 4259 4047976 SGTC_1304 1165-0502 251 µM -1.19577486662912 0.120838348672332 no 2946 0.115892213208811 4263 767425 SGTC_763 3453-1109 128 µM -1.1957783178743 0.120837685534943 no 2947 0.115891539625959 4300 1560353 SGTC_561 1550-0330 72.9 µM -1.19708317976895 0.120587147166577 no 2948 0.115637067650121 4227 6812934 SGTC_191 3914-0123 66.505 µM -1.19789092159069 0.12043224111532 no 2949 0.115479742239373 4291 3144412 SGTC_2488 5268135 45.7 µM -1.2020909797571 0.119629026974467 no 2950 0.114664140392887 4337 1270356 YLR208W SEC13 SGTC_3332 9141069 11.198 µM -1.20545570464344 0.118988292494771 no 2951 0.114013714069341 4237 17332883 SGTC_2118 5526350 200 µM -1.2054769261241 0.118984259056721 no 2952 0.1140096201579 4324 743594 SGTC_2312 7706453 155.7 µM -1.20711479090836 0.118673251261756 no 2953 0.113693969723745 4284 976098 SGTC_564 3555-0129 330 µM -1.21374465371077 0.117420201622481 no 2954 0.112422623480753 4179 563260 SGTC_894 0960-0238 55.9 µM -1.21486097360373 0.117210141200787 no 2955 0.112209560336406 4303 6741907 YDL195W SEC31 SGTC_2115 tiliquinol 12.7705 µM -1.21695154066678 0.116817470861464 no 2956 0.111811326974047 4277 71208 A bioactive hydroxyquinoline. SGTC_254 nsc-64875 3.808 µM -1.21831233702795 0.116562374636136 no 2957 0.111552651804788 4296 56993 SGTC_648 0375-0473 33.3 µM -1.21916030260717 0.116403614105181 no 2958 0.11139167787628 4270 1713139 SGTC_426 0988-0037 14.6 µM -1.21941474727694 0.116356005583575 no 2959 0.111343407703039 4346 5383008 SGTC_1552 6-methylflavone 10.6 µM -1.2226930190134 0.115743851449002 no 2960 0.110722832343622 4249 689013 SGTC_871 0574-0004 149 µM -1.2238714318238 0.115524365419958 no 2961 0.110500366065725 4268 9551173 SGTC_3273 9137859 49.47 µM -1.22445847745693 0.115415135284743 no 2962 0.110389660500416 4406 2377234 SGTC_1300 1094-0077 113 µM -1.22494989834297 0.115323754262598 no 2963 0.110297049098935 4270 5532636 SGTC_1352 1496-0991 99 µM -1.22781891794631 0.114791278904056 no 2964 0.109757476183031 4296 3000039 SGTC_3127 9126946 49.47 µM -1.22939920597366 0.11449873369536 no 2965 0.109461083913629 4287 27243249 SGTC_2652 actinonin 100 µM -1.2315594825072 0.114099679337692 no 2966 0.109056842048161 4346 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2655 perillic acid 100 µM -1.23263186375754 0.113901953438535 no 2967 0.108856571630798 4343 5702197 An apoptosis inducer. SGTC_3238 9133470 49.47 µM -1.2352067401179 0.11342819439244 no 2968 0.108376785719702 4319 3534688 SGTC_1821 st053465 65.6 µM -1.23688774018112 0.113119661464364 no 2969 0.108064381067391 4329 675086 SGTC_2327 6189656 200 µM -1.23792419324735 0.112929728223747 no 2970 0.107872085350906 4400 5349088 SGTC_658 3253-0951 102 µM -1.23797020036968 0.112921302555518 no 2971 0.107863555251172 4310 1184878 SGTC_1520 flindersine 88 µM -1.23963745520732 0.112616266991572 no 2972 0.107554760194473 4373 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2391 6285546 200 µM -1.2401035761392 0.112531092370126 no 2973 0.107468543215098 4329 846083 SGTC_3291 9121177 71.43 µM -1.24323917093938 0.111959318610711 no 2974 0.106889856094379 4307 17015612 SGTC_567 1080-0542 68.4 µM -1.24359642042863 0.111894306445917 no 2975 0.106824067140536 4199 5950415 SGTC_1068 loratadine 26.9 µM -1.24488453193535 0.111660120428331 no 2976 0.10658709874031 4372 3957 A H1 histamine antagonist. SGTC_2065 5221596 34.26 µM -1.24503043856043 0.111633615896787 no 2977 0.106560280862164 4287 788581 SGTC_3204 9114183 49.47 µM -1.24673728014796 0.111323895448412 no 2978 0.106246922283004 4298 17027248 SGTC_2724 maprotiline 69.64 µM -1.24810400688041 0.111076335479405 no 2979 0.105996485558264 4267 4011 A tricyclic antidepressant. SGTC_940 3232-1287 54.8 µM -1.25015001189217 0.110706472743634 no 2980 0.105622376700806 4323 1585493 YIL048W NEO1 SGTC_3340 9146634 11.102 µM -1.2509550233487 0.110561190506871 no 2981 0.105475443628687 4321 4907387 SGTC_941 3237-0776 460 µM -1.25106810991711 0.110540792470918 no 2982 0.105454814582027 4365 760008 SGTC_562 3772-2733 112 µM -1.25315589597943 0.110164691746849 no 2983 0.105074488567021 4315 2876874 YIL048W NEO1 SGTC_127 0180-0333 59.125 µM -1.25325776884613 0.110146363545314 no 2984 0.105055956113944 4246 771601 SGTC_2589 lobaric acid 100 µM -1.25361425815988 0.11008224388358 no 2985 0.104991123108705 4294 73157 A novel microtubule depolymerizer. SGTC_939 1165-0479 45.3 µM -1.25508788648544 0.109817475057362 no 2986 0.104723428690416 4314 1377347 SGTC_1459 k035-0031 35.7 µM -1.25524674390941 0.109788960241124 no 2987 0.104694600721229 4062 3877128 YMR208W ERG12 SGTC_2738 aclarubicin 5.55 µM -1.25586845543927 0.109677414479261 no 2988 0.104581833552445 4334 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1499 4480-0877 67.3 µM -1.25656024212563 0.109553391688812 no 2989 0.104456459475402 4325 2861909 SGTC_217 ketoconazole 989 nM -1.25720695859062 0.109437540148783 no 2990 0.104339352099977 4145 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1391 3442-0225 151 µM -1.25816882480394 0.10926539608955 no 2991 0.104165353467065 4298 5227075 SGTC_2142 5622915 118.518 µM -1.26116643246268 0.108730165860473 no 2992 0.103624444919303 4341 5322196 SGTC_3346 9158254 43.5805 µM -1.26451189899728 0.108135053817014 no 2993 0.103023176293162 4345 17639500 SGTC_1704 st028805 70.8 µM -1.26610357442404 0.107852741501071 no 2994 0.10273800153927 4377 2876101 SGTC_663 1486-0733 13.9 µM -1.26806942054586 0.107504796471098 no 2995 0.102386580342023 4355 722445 YPR165W RHO1 SGTC_327 1273-0057 3.96 µM -1.2752167219772 0.106246578079083 no 2996 0.101116272084899 4241 3108138 SGTC_2232 chlorophetanol 41.5365 µM -1.27525055924796 0.106240646735541 no 2997 0.101110285543031 4412 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1800 st050079 29.0735 µM -1.27607719779345 0.106095819344424 no 2998 0.10096411561266 4177 3645560 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.2767703273085 0.105974492771947 no 2999 0.100841672132053 4378 2374 Ca(2+)-ATPase inhibitor. SGTC_709 3807-1509 243 µM -1.27756352613926 0.10583577294993 no 3000 0.100701683988999 4413 1886677 YPL242C IQG1 SGTC_882 0843-0131 351 µM -1.27866535539655 0.105643295667283 no 3001 0.100507462291781 4339 5425421 SGTC_1010 4112-3296 15.2 µM -1.28387629362836 0.10473643159103 no 3002 0.099592621610486 4383 704384 SGTC_1493 4348-0038 111 µM -1.2841357815199 0.104691420505343 no 3003 0.0995472250765493 4324 800424 SGTC_702 1488-0190 94 µM -1.28554931658696 0.104446473003086 no 3004 0.0993001974154667 4383 949357 SGTC_801 0866-0028 10.1 µM -1.28857125103794 0.103924203902262 no 3005 0.0987735917100148 4368 6849771 SGTC_1188 1403-0014 4.57 µM -1.29193734748459 0.103344687386661 no 3006 0.0981894213049361 4365 9614867 SGTC_1273 0849-0096 14.1 µM -1.29200475602622 0.103333106154362 no 3007 0.0981777487703842 4375 5286025 SGTC_768 0384-0033 77.3 µM -1.2965889661998 0.102547718003552 no 3008 0.0973863254605784 4317 3965305 YMR134W ERG29 SGTC_193 1273-0060 1.558 µM -1.29983390181435 0.10199440968995 no 3009 0.0968289516710012 4196 2847393 YHR072W ERG7 SGTC_2102 5377816 72.7585 µM -1.30001935054283 0.101962853761802 no 3010 0.0967971685520395 4419 1379702 SGTC_279 1273-0055 2.93 µM -1.30380154548785 0.101320825385669 no 3011 0.0961506277767332 4400 2847562 SGTC_344 k064-0035 6.43 µM -1.30748722098181 0.100698019595663 no 3012 0.0955236460885026 4313 5088750 SGTC_2619 obliquin 87.91 µM -1.30809608361652 0.100595403236205 no 3013 0.0954203608301963 4332 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1462 k081-0014 26.5 µM -1.30872409890255 0.100489638872397 no 3014 0.0953139127344969 3826 3270634 SGTC_2100 5377183 190 µM -1.31100602723452 0.1001060211925 no 3015 0.0949278636572559 4391 2844202 SGTC_2879 9041815 71.43 µM -1.31121792484635 0.100070453159531 no 3016 0.094892074056975 4397 4942971 SGTC_2678 equilin 100 µM -1.31225360929147 0.0998967413060095 no 3017 0.0947172895328637 4361 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2987 9018338 71.43 µM -1.31369761423775 0.0996549109823092 no 3018 0.09447399207626 4385 5055682 SGTC_743 1275-0778 158 µM -1.31601729696924 0.0992673251600389 no 3019 0.0940841185996377 4366 2849257 YMR203W TOM40 SGTC_2012 4023501 200 µM -1.31735883971701 0.0990436761893594 no 3020 0.0938591854327201 4373 3477460 SGTC_2884 9058502 51.95 µM -1.31792638877151 0.0989491709522013 no 3021 0.0937641454539242 4395 6471554 SGTC_1443 4112-3303 14 µM -1.31801817473405 0.0989338934431748 no 3022 0.0937487819415498 4419 704433 SGTC_3288 9119690 36.221 µM -1.32062065689479 0.0985014356646894 no 3023 0.0933139408049678 4365 17595618 YKL019W RAM2 SGTC_2701 st077767 14.721 µM -1.32477001607478 0.0978147964541162 no 3024 0.0926237212692092 4365 5721188 SGTC_1118 chelidonine 707.474 nM -1.32534416218178 0.0977200633177344 no 3025 0.092528513910309 4366 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1870 st057514 26.5 µM -1.32829645951092 0.0972340013257591 no 3026 0.0920400944549969 4382 5393161 SGTC_1883 5-benzylidenerhodanine 20 µM -1.3334251858303 0.0963938370441442 no 3027 0.0911961559134532 4360 1273210 SGTC_2959 9079155 11 µM -1.34433638456012 0.094624185329551 no 3028 0.0894198174756046 4413 16189457 SGTC_32 0928-0142 34.1 µM -1.35133442787043 0.0935018704827929 no 3029 0.088294164179272 4393 2244242 SGTC_1122 capsaicin 818.572 nM -1.35342929302632 0.0931678250328805 no 3030 0.0879592622516199 4454 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1650 st011916 45.8 µM -1.35489782759273 0.0929341801047259 no 3031 0.0877250559502753 4348 242528 SGTC_3159 9100096 49.47 µM -1.35788021198329 0.0924610142070633 no 3032 0.0872508486434983 4349 25236875 SGTC_248 streptozotocin 5.23457 mM -1.35875277104015 0.092322917222582 no 3033 0.0871124719005501 4435 5300 DNA alkylating agent. SGTC_2148 5546263 113.568 µM -1.36325113346313 0.0916133978566097 no 3034 0.0864016885077379 4430 792097 SGTC_430 0958-0115 16.4 µM -1.37085460267845 0.0904233147210735 no 3035 0.0852101427664632 4339 6833180 SGTC_131 0141-0277 33.849 µM -1.37132542378088 0.0903500017239413 no 3036 0.0851367668506297 4379 1547771 SGTC_465 cgp-37157 41 µM -1.37342528192881 0.0900235637794267 no 3037 0.0848100873246835 4459 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_865 0488-0499 301 µM -1.37355225304098 0.0900038533474875 no 3038 0.0847903643266532 4366 9634651 SGTC_1930 st074634 34.3 µM -1.37361896918436 0.0899934979147277 no 3039 0.0847800023843028 4329 684253 YOR116C RPO31 SGTC_2407 paclitaxel 400 µM -1.37560752506973 0.089685247964785 no 3040 0.0844715878427082 4462 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.37572678670109 0.0896667859673353 no 3041 0.0844531177822404 4410 689007 SGTC_3249 9135183 49.47 µM -1.37738875585326 0.0894098029902548 no 3042 0.0841960436911488 4386 4902779 SGTC_3052 9092717 49.47 µM -1.37943759738488 0.0890937541089676 no 3043 0.0838799369366105 4424 25237534 SGTC_2223 6903751 107.57 µM -1.38040352507791 0.0889450413731146 no 3044 0.08373121771585 4400 5598863 SGTC_514 4466-0038 2.65 nM -1.38069101924642 0.088900814919642 no 3045 0.0836869919011683 4212 5722064 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.38186638680562 0.0887201734012201 no 3046 0.0835063652346273 4493 4620898 SGTC_641 4092-0595 30 µM -1.38281738640406 0.0885742150327972 no 3047 0.0833604332585756 4474 786260 SGTC_1242 0402-0103 60.1 µM -1.38371886977856 0.0884360215751304 no 3048 0.0832222766700879 4348 432868 SGTC_395 anisomycin 6.25 µM -1.38604943538641 0.0880795006658852 no 3049 0.0828659044011532 4439 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_959 1222-0044 107 µM -1.40174595584166 0.0857061752828847 no 3050 0.0804955610593408 4430 6083612 SGTC_3164 9100705 49.47 µM -1.40350742667553 0.0854428562843572 no 3051 0.0802327894591746 4444 17174235 SGTC_1771 st048882 4.1505 µM -1.40474439238735 0.0852583070532311 no 3052 0.0800486500006999 4463 4580403 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.4063811408581 0.0850145714283417 no 3053 0.0798054886680931 4307 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_965 1291-5240 308 µM -1.40900840821965 0.0846244257123623 no 3054 0.0794163409463439 4434 2834598 SGTC_916 4466-0038 42 nM -1.40957142691376 0.0845409931861774 no 3055 0.079333134462467 4500 5722064 YGL116W CDC20 SGTC_464 bw-b 70c 158 µM -1.41123168151266 0.0842953229108345 no 3056 0.0790881556931931 4449 5353454 SGTC_1921 5740136 50 µM -1.41313950133424 0.0840136820505875 no 3057 0.0788073553316523 4390 1774243 SGTC_2931 9014674 55.67 µM -1.41694013541523 0.0834547221833377 no 3058 0.0782502154059497 4404 2996810 SGTC_2863 9028737 58.44 µM -1.42031476283135 0.0829607618955428 no 3059 0.0777580325875835 4439 6460917 SGTC_538 2922-0838 53.3 µM -1.42154211182135 0.0827816554159006 no 3060 0.0775796100491899 4468 777039 SGTC_807 1315-0151 48 µM -1.42716136755426 0.0819653539792675 no 3061 0.076766693561261 4467 4011080 SGTC_1073 triclabendazole 3.09 µM -1.42790001660135 0.081858504086621 no 3062 0.0766603194260033 4480 50248 An antihelmetic and likely tubulin inhibitor. SGTC_376 3970-0862 59.1 µM -1.42868143871024 0.0817455811273946 no 3063 0.0765479075300137 4474 3135186 SGTC_2238 6671620 73.2395 µM -1.42930961928423 0.0816548882066006 no 3064 0.0764576312238002 4369 729941 SGTC_1061 3448-9325 110 µM -1.43151169808362 0.0813375643761234 no 3065 0.0761418083741788 4410 723482 SGTC_2594 a-mangostin 100 µM -1.43256677414046 0.0811858558868937 no 3066 0.0759908413449107 4453 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_154 3389-1638 511.116 µM -1.43275978806122 0.0811581256960691 no 3067 0.0759632483551985 4434 5238686 SGTC_2141 5621638 7.665 µM -1.43413204382567 0.0809611805586518 no 3068 0.075767292547921 4484 2856238 SGTC_824 1304-0008 100 µM -1.43587375244803 0.080711731601422 no 3069 0.0755191342553336 4480 768245 SGTC_606 k015-0008 38.6 µM -1.43975842157707 0.0801574575269894 no 3070 0.0749678791540393 4517 1970475 SGTC_129 0088-0017 176.636 µM -1.44133796626657 0.07993290883056 no 3071 0.0747446131413962 4315 182446 SGTC_338 4055-0136 114 µM -1.4434772551771 0.0796295454781852 no 3072 0.0744430375859978 4434 2900563 SGTC_2873 9040596 71.43 µM -1.44907751456086 0.0788395223155575 no 3073 0.0736579683201613 4432 6463863 SGTC_2846 9008642 19.48 µM -1.44960610966255 0.0787652617075655 no 3074 0.0735841956477135 4481 2992898 SGTC_383 2324-0395 7.37 µM -1.45020627075255 0.0786810112901126 no 3075 0.0735005034625722 4450 3146421 SGTC_488 nitrendipine 139 µM -1.45329826795297 0.0782480396764809 no 3076 0.073070479004419 4494 4507 Dihydropyridine L-type calcium channel blocker. SGTC_811 0416-0114 265 µM -1.45868314202613 0.0774983142839288 no 3077 0.0723261690466827 4489 6612453 SGTC_1849 st056239 19.2 µM -1.46532880539841 0.0765805872666354 no 3078 0.0714156155772309 4466 5393181 SGTC_547 1120-0019 610 nM -1.4659751405586 0.0764917751090527 no 3079 0.0713275297342964 4458 3676939 SGTC_1138 3761-0006 1.03 µM -1.46624219832438 0.0764551018980078 no 3080 0.0712911581018961 4507 12061087 SGTC_1327 1436-0082 2.18 µM -1.46807873980222 0.0762032644582645 no 3081 0.0710414179067578 4492 15992205 SGTC_1227 3909-8010 46.6 µM -1.46907534058153 0.0760668691832563 no 3082 0.0709061776980619 4464 15982272 SGTC_2747 doxorubicin 7.63 µM -1.47250714173229 0.0755986128833816 no 3083 0.0704419899409832 4525 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.47437905505228 0.0753441247751824 no 3084 0.0701897802854015 4477 688669 SGTC_1689 st020265 53.493 µM -1.47555298807614 0.075184861137022 no 3085 0.0700319667625082 4474 5758320 YPR016C TIF6 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.47627197152793 0.0750874458363885 no 3086 0.0699354476534552 4556 688801 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.48562773041326 0.0738285909538413 no 3087 0.0686888079862042 4486 641818 YHR062C RPP1 SGTC_2030 5175110 200 µM -1.4877880054852 0.0735402225791989 no 3088 0.0684034049336994 4479 2831986 SGTC_2892 9047358 58.44 µM -1.48864048212314 0.0734266654178133 no 3089 0.0682910327433027 4494 6466771 SGTC_3311 9131146 2.8755 µM -1.49038572394956 0.073194602694037 no 3090 0.0680614220155746 4431 4900406 YPR165W RHO1 SGTC_2180 6301957 200 µM -1.49191856715729 0.0729912455976749 no 3091 0.0678602472880595 4514 845462 SGTC_3345 9148410 3.559 µM -1.49410846354333 0.0727014700618608 no 3092 0.0675736361024537 4431 4903596 SGTC_878 0828-0289 13.7 µM -1.49440906095666 0.0726617627100024 no 3093 0.0675343673649323 4450 745350 YLR208W SEC13 SGTC_1716 st033144 30.6155 µM -1.49516991785481 0.0725613317014211 no 3094 0.067435051136755 4462 674617 SGTC_2445 5742597 35.57 µM -1.49587301886044 0.0724686188675314 no 3095 0.0673433742934604 4500 1774255 SGTC_3032 9089427 49.47 µM -1.49849568499961 0.0721235873582451 no 3096 0.0670022564428621 4474 17173707 SGTC_2753 fluvastatin 17.09 µM -1.5027331259759 0.0715687828038842 no 3097 0.0664539384327312 4483 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2139 5578692 56.4705 µM -1.50284766024359 0.0715538325088022 no 3098 0.0664391662473855 4472 650991 YMR113W FOL3 SGTC_2948 9070189 9.45 µM -1.50428493760296 0.0713664266325618 no 3099 0.0662540078523913 4440 6473636 YDL196W YDL196W SGTC_1215 3852-0577 11.2 µM -1.50694930957344 0.0710200173281949 no 3100 0.0659118254173687 4517 2884876 SGTC_1882 5615643 20 µM -1.50841209017734 0.0708303832770519 no 3101 0.0657245452980065 4473 2253075 SGTC_2697 mebhydrolin 72.4 µM -1.51055830536638 0.0705528535799663 no 3102 0.065450511863229 4528 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2096 5468907 200 µM -1.51056809663497 0.0705515893772075 no 3103 0.0654492637263989 4500 759785 SGTC_83 0170-0301 39.027 µM -1.5118002640212 0.0703926366201877 no 3104 0.0652923411193819 4528 3089716 SGTC_1430 4049-0248 69.1 µM -1.51483150272701 0.070002771014606 no 3105 0.0649075401999964 4525 22774488 SGTC_2145 5634607 200 µM -1.51577162141724 0.0698821949026214 no 3106 0.0647885551046568 4507 308662 SGTC_1181 1222-0449 220 µM -1.5178092391269 0.0696214063366584 no 3107 0.0645312476472521 4543 658318 SGTC_1230 0170-0365 3.77 µM -1.5229207881 0.0689704922646559 no 3108 0.0638892621134659 4525 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2348 9022543 33.42 µM -1.52592772220713 0.0685897809393167 no 3109 0.0635139328861633 4510 3162678 YDL140C RPO21 SGTC_393 acivicin 6.25 µM -1.52623789410128 0.0685506021290137 no 3110 0.0634753146832058 4364 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1164 k060-0068 93.7 µM -1.52962518464071 0.0681238654266852 no 3111 0.0630547659609171 4513 5963676 SGTC_2629 bisabolol 100 µM -1.53254275325571 0.0677579514484242 no 3112 0.0626942779260192 4523 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_489 paxilline 115 µM -1.53316110951162 0.0676805941270103 no 3113 0.0626180819446188 4476 105008 A toxic potassium channel blocker. SGTC_2464 5717415 7.67 µM -1.53321744595774 0.0676735497432504 no 3114 0.06261114356358 4474 5285744 SGTC_415 dibenzyl ketone 100 µM -1.53500691679191 0.0674500865613538 no 3115 0.062391064516522 4488 7593 SGTC_1597 7-benzyloxygramine 47.5 µM -1.53566789279243 0.0673676904466899 no 3116 0.0623099267485066 4414 260807 SGTC_705 1124-0212 310 µM -1.53766253510609 0.067119513429685 no 3117 0.0620655742803822 4507 9554485 SGTC_1862 st057513 3.81 µM -1.54120032272573 0.0666810752425823 no 3118 0.061634019496673 4496 5393163 SGTC_2246 7293507 91.5585 µM -1.54273238305175 0.0664918960643285 no 3119 0.0614478606708474 4551 887656 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.542883702402 0.0664732336830654 no 3120 0.0614294978934953 4578 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1340 1486-1359 257 µM -1.54359378099913 0.0663857130694242 no 3121 0.0613433862828562 4468 4309068 SGTC_130 0136-0219 337.655 µM -1.54719119158937 0.0659436852542688 no 3122 0.0609085746835777 4407 234244 SGTC_690 glyoxal 20.3 µM -1.55420255010153 0.0650887305390347 no 3123 0.0600680547163879 4327 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_126 0417-1624 672.48 µM -1.55489510487093 0.0650047504125014 no 3124 0.0599855267030844 4569 41912 YDL195W SEC31 SGTC_659 k018-0002 107 µM -1.55505896799913 0.0649848924574963 no 3125 0.0599660130150126 4494 6797879 YHR007C ERG11 SGTC_320 4092-0846 5.34 µM -1.55564369421325 0.064914070069648 no 3126 0.0598964212436324 4492 1359356 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.56072594118862 0.0643010264945001 no 3127 0.0592942139056438 4559 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1856 st057054 55.7 µM -1.56209241874552 0.0641369657178809 no 3128 0.0591331093051581 4500 1266018 SGTC_2979 9012552 45.46 µM -1.56353059611887 0.0639646482399679 no 3129 0.0589639224822837 4543 17100905 SGTC_2335 9018011 154.17 µM -1.56412482699262 0.0638935547285959 no 3130 0.0588941282864172 4501 6458208 SGTC_634 1611-4317 11.2 µM -1.56500195088197 0.0637887283437101 no 3131 0.0587912259383454 4551 2843522 SGTC_3189 9110682 49.47 µM -1.57370168205869 0.0627562411368734 no 3132 0.0577782163971038 4535 17122418 SGTC_1414 3917-0015 5.4 µM -1.57801994387933 0.0622486081024124 no 3133 0.057280514044741 4519 6618702 SGTC_2853 9015042 58.44 µM -1.58019596876349 0.0619940221138262 no 3134 0.0570309973473767 4466 6457456 SGTC_2369 9071472 200 µM -1.58521199497882 0.0614102630125576 no 3135 0.0564590880509971 4554 17296037 SGTC_1691 st019933 84.6 µM -1.58531766407619 0.0613980117110813 no 3136 0.0564470888307765 4534 6176082 SGTC_2192 5915882 198.485 µM -1.58652566040432 0.0612580919507552 no 3137 0.0563100579731797 4527 2876149 SGTC_2646 retinol 96.75 µM -1.59798760538551 0.0599428451632596 no 3138 0.0550228677846099 4559 445354 A vitamin A analog and teratogen. SGTC_284 0988-0104 32.6 µM -1.60088873715356 0.0596134757983013 no 3139 0.054700782301416 4526 4666532 SGTC_1877 wortmannin 25 µM -1.60221428958311 0.0594634568848994 no 3140 0.0545541156204303 4562 312145 A covalent inhibitor of PI 3-kinase. SGTC_1975 st070967 30.8 µM -1.60299314951793 0.0593754478161621 no 3141 0.0544680832699469 4545 261391 SGTC_3296 9122258 64.045 µM -1.60774828318127 0.0588403436377564 no 3142 0.0539451596198269 4535 4730474 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.61945271404525 0.0575393416405457 no 3143 0.0526749463534663 4501 2724 A muscle relaxant with antifungal properties. SGTC_1769 st044406 64.4 µM -1.62290476941793 0.0571599816707254 no 3144 0.0523048819285936 4538 670903 SGTC_432 NS 1619 61.3 µM -1.62967399683711 0.0564218020732634 no 3145 0.0515852079733922 4521 4552 A K+/calcium channel activator. SGTC_219 mitoxanthrone 164.414 µM -1.63712034451666 0.0556184834379867 no 3146 0.0508026632239141 4517 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3349 9149703 23.001 µM -1.63936995949558 0.0553775767799762 no 3147 0.0505681170216868 4573 4910494 SGTC_2133 5320837 200 µM -1.64009880649401 0.0552997030136116 no 3148 0.0504923122749858 4576 2841355 SGTC_542 3381-0244 89.3 µM -1.64452689065611 0.0548284409634897 no 3149 0.0500337072133358 4580 1112843 SGTC_921 1561-0023 372 µM -1.64841254682127 0.0544175272583138 no 3150 0.0496340215400717 4550 24050882 SGTC_2183 6420625 130.508 µM -1.65846945754064 0.0533653021098484 no 3151 0.0486113736525378 4602 2897619 SGTC_2191 5911152 200 µM -1.65912686680429 0.0532970847215526 no 3152 0.048545115230664 4597 2875902 SGTC_3264 9137442 49.47 µM -1.66093000933789 0.0531103327715513 no 3153 0.0483637521902299 4535 17015726 SGTC_1981 st071826 47 µM -1.66277145419721 0.0529201497198468 no 3154 0.0481790963848981 4604 11838600 SGTC_1451 4152-0210 104 µM -1.66438746993392 0.052753694206675 no 3155 0.0480175112228411 4600 659563 SGTC_2296 7971656 126.45 µM -1.66465837484057 0.0527258307130582 no 3156 0.0479904659819062 4564 666570 SGTC_3081 9117243 49.47 µM -1.6667503700041 0.0525110549488529 no 3157 0.0477820262850838 4530 45595589 SGTC_1760 st045453 10.4495 µM -1.67157875313586 0.0520179974433126 no 3158 0.0473037086739519 4580 3323419 YIL048W NEO1 SGTC_1604 st002052 72.4 µM -1.67414700269401 0.051757239340569 no 3159 0.0470508560773108 4613 6254834 YHR062C RPP1 SGTC_1374 2889-5571 141 µM -1.6782394094558 0.0513438793414458 no 3160 0.0466501855652654 4576 2853281 SGTC_3166 9102297 49.47 µM -1.67904912112837 0.0512624051705826 no 3161 0.0465712354298216 4594 25237072 SGTC_157 1348-1695 65.819 µM -1.68774403331893 0.0503939805070472 no 3162 0.0457301875812469 4498 5380510 SGTC_1254 0550-0035 264 µM -1.68905314786373 0.0502642510055573 no 3163 0.0456046226548952 4567 15121435 SGTC_352 k048-0007 5.11 µM -1.69026206475435 0.0501446873364046 no 3164 0.0454889145974654 4509 6811911 SGTC_2785 7756463 72.73 µM -1.69043030858491 0.050128065760162 no 3165 0.0454728303455224 4553 2201551 SGTC_3305 9127027 53.8275 µM -1.69743514586225 0.0494399158981391 no 3166 0.0448072113183559 4543 41905295 SGTC_528 3492-0019 172 µM -1.69806852006095 0.0493780672727867 no 3167 0.0447474151099865 4582 2869262 SGTC_103 0844-0104 51.839 µM -1.69854192780884 0.0493318796296193 no 3168 0.0447027631487514 4411 5375804 SGTC_2164 5685496 200 µM -1.7009328973179 0.0490991334320564 no 3169 0.0444777941755219 4525 759046 SGTC_102 gallobenzophenone 83.616 µM -1.70345888421505 0.0488541977754124 no 3170 0.044241113076406 4567 70837 SGTC_1256 0570-0116 285 µM -1.70540011903281 0.0486666277042822 no 3171 0.0440599130831307 4576 410638 SGTC_3043 9092303 49.47 µM -1.70831910982933 0.0483856669639677 no 3172 0.0437885736678054 4592 25236084 SGTC_2936 9038235 15.59 µM -1.71394007837298 0.0478482888759806 no 3173 0.0432698657075662 4525 4749415 SGTC_920 mycophenolic acid 780.421 nM -1.71411514903176 0.0478316287414684 no 3174 0.0432537900561007 4579 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1134 3477-0009 42.5 µM -1.72201705900902 0.0470844876590494 no 3175 0.0425332141555223 4602 3973534 SGTC_2060 5238662 140 µM -1.72224837267203 0.0470627582695338 no 3176 0.0425122677812899 4566 790130 SGTC_513 4245-1575 41.7 µM -1.72451426944869 0.0468503269268734 no 3177 0.042307522600216 4421 719745 SGTC_706 4262-0057 46.9 µM -1.73122669846918 0.04622553730322 no 3178 0.0417056696454911 4590 883298 SGTC_890 0929-0006 47.2 µM -1.7315673048651 0.0461940130645031 no 3179 0.0416753158601033 4603 1378169 SGTC_1754 st042065 16.137 µM -1.73188562372303 0.0461645672201361 no 3180 0.0416469644496611 4350 1126236 YIL048W NEO1 SGTC_507 nimesulide 162 µM -1.73813288066314 0.0455897146487748 no 3181 0.0410937011930265 4616 4495 A COX2 inhibitor. SGTC_3327 9140648 26.9345 µM -1.74410423782062 0.045045642718275 no 3182 0.0405704576210501 4612 8029710 SGTC_2179 6298986 200 µM -1.75015089616586 0.0445000470946557 no 3183 0.040046139666045 4570 738374 SGTC_1637 st007924 17.4 µM -1.75102260554274 0.044421832875483 no 3184 0.0399710081119942 4532 683336 SGTC_2159 5658611 73.75 µM -1.75482249134063 0.0440821806540644 no 3185 0.0396448376039403 4592 793844 SGTC_2720 fluspirilene 36.88 µM -1.75510085769829 0.044057381460314 no 3186 0.0396210288264827 4606 3396 An atypical antipsychotic. SGTC_3307 9126885 69.2785 µM -1.75537025430096 0.0440333920795981 no 3187 0.0395979983086725 4583 24824909 SGTC_2518 prenyletin 46.28 µM -1.75546037898075 0.0440253689579243 no 3188 0.0395902960467402 4647 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1672 st016598 6.51 µM -1.75668835081753 0.0439161692792749 no 3189 0.0394854721063728 4581 4665860 YNL267W PIK1 SGTC_3248 9135562 49.47 µM -1.75779752671719 0.0438177216271489 no 3190 0.03939098316674 4596 17650701 SGTC_1905 st060207 84.5 µM -1.77009613952183 0.0427380162095597 no 3191 0.0383555632770946 4607 1948547 SGTC_1966 st070145 16.1 µM -1.77097065128989 0.0426620683828414 no 3192 0.0382827911484239 4594 3748532 SGTC_1917 st066507 28.5 µM -1.77125944998267 0.0426370113590101 no 3193 0.0382587836289292 4544 3156428 SGTC_539 4859-0462 2.54 µM -1.7722281223059 0.0425530533754864 no 3194 0.038178348587208 4629 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_112 phenothiazine 287.218 µM -1.77370466993085 0.0424253334375387 no 3195 0.0380560067957979 4582 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2766 oltipraz 83.91 µM -1.78120738484843 0.041781138618056 no 3196 0.037439288844758 4596 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2390 9097792 176.6 µM -1.78292262879249 0.0416349831939816 no 3197 0.0372994494644917 4631 4497149 SGTC_40 0327-0103 19.753 µM -1.78421839406183 0.0415248462637566 no 3198 0.0371940922650811 4473 409036 SGTC_3139 9095020 49.47 µM -1.7898796535535 0.0410464184487819 no 3199 0.0367366302012014 4530 25236292 SGTC_1038 k292-0204 154 µM -1.7900511120066 0.0410319986924768 no 3200 0.0367228474979969 4566 4454212 SGTC_2056 5235370 200 µM -1.79500059604655 0.0406175122021609 no 3201 0.0363268024854247 4538 5511916 SGTC_2218 6965428 192.983 µM -1.79598992273869 0.0405350715584997 no 3202 0.0362480598663696 4538 675684 SGTC_2675 theaflavin digallate 100 µM -1.79917746924321 0.0402703766089115 no 3203 0.0359953061356275 4581 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1347 1493-0251 600 nM -1.80551167460575 0.0397485489292925 no 3204 0.0354973251491718 4659 3986378 SGTC_2394 5221648 200 µM -1.81286313107747 0.039149824525342 no 3205 0.0349264669801862 4630 788586 SGTC_3253 9135987 49.47 µM -1.81787015495372 0.0387462557985524 no 3206 0.0345419904215222 4644 4182430 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.83482652800066 0.0374046677343078 no 3207 0.033265698333542 4616 1241132 A phosphatase inhibitor. SGTC_732 3970-1727 52.7 µM -1.84205868924673 0.0368441194307976 no 3208 0.0327332828126763 4675 1275699 SGTC_3252 9135871 49.47 µM -1.84318104293184 0.0367577472319666 no 3209 0.0326512908791461 4658 17682838 SGTC_116 0155-0182 31.788 µM -1.84439127931123 0.0366647975284136 no 3210 0.0325630686569473 4508 771486 SGTC_1438 4092-1045 4 µM -1.84467858188416 0.0366427601096333 no 3211 0.0325421541539541 4670 1351342 SGTC_20 0481-0013 4.944 µM -1.84657432565411 0.0364976193910547 no 3212 0.0324044290284048 4684 182045 SGTC_1522 st012842 45.6 µM -1.85485233707072 0.0358693455507514 no 3213 0.031808657933046 4487 3491067 YOR116C RPO31 SGTC_2354 9060492 162 µM -1.85880628914575 0.0355723956377406 no 3214 0.0315273003507154 4635 6471895 SGTC_2941 9056145 11.23 µM -1.86585420538315 0.0350480816721388 no 3215 0.0310308830607623 4606 2119517 SGTC_2520 obtusaquinone 4.71 µM -1.866117122888 0.0350286458762363 no 3216 0.0310124904216236 4657 5967872 SGTC_512 prima-1 270 µM -1.87107316765953 0.034663929342394 no 3217 0.0306674700771216 4648 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3030 9087619 49.47 µM -1.87116388318046 0.0346572827416265 no 3218 0.0306611845628372 4637 25236973 SGTC_3027 9089541 49.47 µM -1.87658977415915 0.0342616347409966 no 3219 0.0302871699892002 4648 9943819 SGTC_985 1493-0307 8.71 µM -1.87695558104053 0.034235094770915 no 3220 0.0302620910307245 4683 3278274 SGTC_1556 plumbagin 1.48 µM -1.89235840172397 0.0331328364005642 no 3221 0.0292216222531997 4589 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2999 9069765 71.4286 µM -1.89559598977806 0.0329049064328393 no 3222 0.0290067439810962 4622 2097066 SGTC_173 1273-0061 2.693 µM -1.90771338255127 0.0320632700959775 no 3223 0.0282141355491497 4606 2847414 YPL266W DIM1 SGTC_1860 st056228 74.6 µM -1.90881513375995 0.0319876354420083 no 3224 0.0281429719413245 4651 688679 SGTC_479 n-linoleoylglycine 10 µM -1.92046986842237 0.0311965306540553 no 3225 0.0273992878127551 4681 6433346 An anti-infammatory. SGTC_1664 st014217 9.02 µM -1.92305656896701 0.0310231619668013 no 3226 0.0272364729563695 4713 3982782 SGTC_51 1013-0126 23.419 µM -1.93062882733807 0.030520223303157 no 3227 0.0267644851318466 4654 1627850 SGTC_3343 9148379 18.9835 µM -1.94409153040152 0.0296427323085813 no 3228 0.02594220721758 4681 1955036 SGTC_144 4161-2749 112.381 µM -1.94937758311678 0.0293039633555984 no 3229 0.0256251747895344 4688 797501 YMR168C CEP3 SGTC_1678 st019265 80.2 µM -1.95926096670334 0.028679189149559 no 3230 0.0250411162434733 4645 5367020 SGTC_2596 sinensetin 100 µM -1.96275102438556 0.0284612299833211 no 3231 0.0248375555524096 4648 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1186 1319-0216 26 µM -1.9629517850334 0.0284487342223864 no 3232 0.0248258883458904 4698 4565136 SGTC_620 0109-0052 432 µM -1.9714054406108 0.0279266892001016 no 3233 0.0243387596239769 4703 493037 SGTC_1109 tnp00067 928.257 nM -1.97334806521342 0.0278078590683732 no 3234 0.0242279601397588 4674 676295 SGTC_2528 xanthyletin 44.79 µM -1.97463324540794 0.0277294765123098 no 3235 0.0241548917148818 4683 65188 An natural product with antifungal activity of unknown mechanism. SGTC_259 usnic acid 108.925 µM -1.9805855782423 0.027368843617746 no 3236 0.0238188837831871 4691 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2935 9038016 29.96 µM -1.98159117840944 0.0273083054204072 no 3237 0.0237625076537409 4631 6463195 SGTC_3339 9145883 14.936 µM -1.98287596049069 0.0272311227196842 no 3238 0.0236906432470772 4623 2030670 SGTC_1394 3474-0001 65.7 µM -1.98613018645944 0.0270364404620774 no 3239 0.0235094351157046 4676 5017666 YIL048W NEO1 SGTC_951 1171-0579 82.7 µM -1.99272850552312 0.0266452639846357 no 3240 0.0231455921071545 4608 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1485 3909-9022 254 µM -1.99300397035485 0.0266290365971682 no 3241 0.023130506162044 4741 714516 SGTC_2346 9031566 143.75 µM -2.00707140309825 0.0258112451060091 no 3242 0.0223710303302267 4676 4771086 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.01831721434097 0.0251726973608059 no 3243 0.0217791175118863 4701 4174840 SGTC_2496 diffractaic acid 79.83 µM -2.04326885993448 0.0238030844795864 no 3244 0.0205129152173463 4676 94870 An apoptosis inducer which activates caspases. SGTC_1434 4073-0095 163 µM -2.04888440483208 0.0235036344547528 no 3245 0.0202367098243686 4713 24133745 SGTC_621 3584-0052 32.1 µM -2.05404647666554 0.0232311677868572 no 3246 0.0199855968090883 4716 2273927 SGTC_1655 st012546 55.1 µM -2.07538867503315 0.0221327314602674 no 3247 0.0189752634691497 4704 720985 YLR208W SEC13 SGTC_2626 ethyl orsellinate 100 µM -2.08738157087458 0.0215349504981551 no 3248 0.0184268282533895 4647 75653 A natural product. SGTC_649 1123-0311 367 µM -2.09768645371284 0.0210322625886968 no 3249 0.017966426150839 4617 693629 YIL048W NEO1 SGTC_2685 mycophenolic acid 18.85 µM -2.11310872617089 0.0202985111594669 no 3250 0.0172957314874548 4726 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2976 9009005 19.48 µM -2.12239897279237 0.0198670668339122 no 3251 0.0169021241944597 4681 2993148 SGTC_1041 0206-0046 107 µM -2.137453024687 0.0191844759442948 no 3252 0.0162805812890821 4704 50494 SGTC_185 k048-0037 25.491 µM -2.14926178676979 0.0186630833433744 no 3253 0.0158068269342829 4744 6827589 SGTC_2761 levamisole 97.89 µM -2.15617496445631 0.0183634799489152 no 3254 0.0155350028304099 4709 26879 An alkaline phosphatase inhibitor. SGTC_695 3505-6186 243 µM -2.16969105963664 0.0177895429256195 no 3255 0.0150151288964548 4701 1819379 SGTC_1505 k297-0037 20.6 µM -2.17364857803746 0.0176244180494409 no 3256 0.0148657686077453 4712 4089396 SGTC_315 k915-0449 187 µM -2.17840672971769 0.0174276207689481 no 3257 0.0146878846554372 4730 20970215 YNL149C PGA2 SGTC_186 3455-3465 67.277 µM -2.18373583194104 0.0172094396362122 no 3258 0.0144908325849322 4748 755278 SGTC_748 act1.228 77.9 µM -2.20118008564085 0.0165114962556275 no 3259 0.0138616387607586 4723 4421505 YNR035C ARC35 SGTC_1609 st001574 46.4 µM -2.20277856706881 0.0164487703356033 no 3260 0.0138051797585738 4724 3960012 SGTC_2171 5739187 198.077 µM -2.20381589376457 0.0164081739014886 no 3261 0.0137686471774941 4697 2262761 SGTC_2726 cimetidine 79.27 µM -2.21545180595177 0.0159586426231527 no 3262 0.0133645344097784 4750 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_176 1486-1328 72.834 µM -2.21781144913578 0.0158687813943218 no 3263 0.013283845577346 4723 22310231 SGTC_505 gw-5074 63.9 µM -2.22008542483686 0.0157825934913867 no 3264 0.0132064846980088 4701 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1516 st013856 110 µM -2.235535376314 0.0152075755688633 no 3265 0.0126911109127247 4717 5281404 A mutagen and neurotoxin. SGTC_3269 9137823 49.47 µM -2.24736277882496 0.0147796311076861 no 3266 0.0123084258720574 4687 17682936 SGTC_358 0075-0058 9.45 µM -2.24867880897862 0.0147326604899767 no 3267 0.0122664691760416 4686 1069125 SGTC_478 N-arachidonylglycine 10 µM -2.24948958641301 0.014703786886767 no 3268 0.0122406823099345 4768 5283389 SGTC_252 miconazole 1.30953 nM -2.25719701746676 0.0144317304301215 no 3269 0.0119978833548349 4668 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3101 9120531 49.47 µM -2.26347554570897 0.0142133251008459 no 3270 0.0118031952065762 4699 24824904 SGTC_932 2857-0803 154 µM -2.28633902578207 0.0134418889993084 no 3271 0.0111172162290684 4709 674898 SGTC_1427 4048-4900 550 nM -2.29277562671925 0.0132313424611211 no 3272 0.0109304629673608 4738 24132586 SGTC_1050 3232-1156 69.3 µM -2.3060676194682 0.012805551936083 no 3273 0.0105534271416639 4724 700529 SGTC_935 2996-0153 430 µM -2.31285797766715 0.0125926435051449 no 3274 0.0103652244448404 4732 23738523 SGTC_1405 3909-7894 12 µM -2.32393951305004 0.012251766476067 no 3275 0.0100643680661046 4746 7104060 SGTC_152 4469-0003 551.229 µM -2.32942473008361 0.0120860154185412 no 3276 0.00991828811344385 4732 697280 SGTC_1690 st023502 41.2 µM -2.34278632719887 0.011690371058614 no 3277 0.00957017060591229 4758 24207482 SGTC_1111 tnp00062 510.699 nM -2.35316060840703 0.0113909831797098 no 3278 0.00930729601878352 4719 676306 SGTC_2424 5537928 59.2 µM -2.35327675474619 0.0113876694149917 no 3279 0.00930438910103109 4738 5382802 SGTC_1562 morin hydrate 59.1 µM -2.35590215107544 0.0113129875109115 no 3280 0.0092388921120284 4735 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_382 3229-0966 23.2 µM -2.35612254217778 0.01130673768519 no 3281 0.00923341231482691 4763 5722370 SGTC_1818 st052136 56.3 µM -2.36523609644474 0.0110509106654988 no 3282 0.00900929000436071 4517 674169 SGTC_3123 9126162 49.47 µM -2.3763411547941 0.0107459974718343 no 3283 0.00874264402827452 4735 25239884 SGTC_1476 4112-3294 3.34 µM -2.38171186988946 0.0106011793251613 no 3284 0.00861618734340248 4739 704369 SGTC_169 k015-0017 16.025 µM -2.40834382326547 0.00990790845726262 no 3285 0.00801254054349037 4705 1840002 SGTC_1555 citronellol 128 µM -2.45789987063103 0.00872268311345739 no 3286 0.00698760663212047 4760 8842 A terpine precursor. SGTC_2700 st077718 96.8 µM -2.47159176635578 0.00841796087569465 no 3287 0.00672565116500357 4739 904970 SGTC_841 0251-0215 91.2 µM -2.47485015586899 0.00834683471648341 no 3288 0.00666460434522802 4778 3888614 SGTC_1081 sertraline 6 µM -2.4793971501063 0.00824846223244901 no 3289 0.00658023393235556 4746 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2612 dictamnine 15.46 µM -2.47947121895077 0.00824686824655617 no 3290 0.00657886742306982 4700 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_474 dl-dihydrosphingosine 5 µM -2.51077817838111 0.00759688578577426 no 3291 0.00602326836192096 4754 3058739 A sphingolipid protein kinase C inhibitor. SGTC_60 0986-0278 202 µM -2.51889077943151 0.00743599530901399 no 3292 0.00588625839745604 4732 3110598 SGTC_1775 st081588 35.1725 µM -2.52965649038675 0.00722712743982965 no 3293 0.0057087123198135 4746 1426443 YGL099W LSG1 SGTC_2382 9035899 200 µM -2.54471665503572 0.00694362790962566 no 3294 0.00546832212088269 4764 6462679 SGTC_2606 farnesol 9.78 µM -2.59576994718042 0.00605427653061742 no 3295 0.00471896164797901 4749 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3215 9129942 49.47 µM -2.60677741285541 0.00587631348086728 no 3296 0.00456993766994061 4751 17682944 SGTC_2387 9077560 195.08 µM -2.62930810192356 0.00552645353887476 no 3297 0.00427794025157678 4769 5303272 SGTC_820 1582-0060 59.9 µM -2.6631383566895 0.00503585316245627 no 3298 0.00387077880714657 4781 3848840 SGTC_440 fluspirilene 35.1 µM -2.66878987453951 0.00495778872675753 no 3299 0.00380625290700563 4763 3396 An atypical antipsychotic. SGTC_445 e6 berbamine 66 µM -2.68011784922561 0.004804554202506 no 3300 0.00367981223334914 4780 6610268 A calcium/calmodulin antagonist. SGTC_270 tamoxifen 5.46 µM -2.68077208877901 0.00479583462917142 no 3301 0.00367262617696414 4764 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_366 0181-0206 4.31 µM -2.69432403576396 0.00461836216027897 no 3302 0.00352657789040327 4749 274874 SGTC_1728 st035614 33.7865 µM -2.70068559905031 0.00453709270235982 no 3303 0.00345983582924014 4743 15945546 SGTC_1329 1447-1697 50.6 µM -2.71959696697824 0.00430298562912969 no 3304 0.00326807639818343 4777 2840515 SGTC_3222 9128301 49.47 µM -2.73273073669532 0.00414681558631337 no 3305 0.00314058294007289 4743 4911358 SGTC_451 chloral hydrate 100 µM -2.74992413506846 0.00395004531920328 no 3306 0.0029804531895201 4773 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1847 st056231 15 µM -2.75646446441309 0.00387741806506432 no 3307 0.0029214980639926 4772 5393180 SGTC_1835 st008666 49.2 µM -2.75874887486896 0.00385233414449098 no 3308 0.00290115522628616 4769 690455 SGTC_2525 harmine 47.85 µM -2.77672558731842 0.00365996208704043 no 3309 0.00274547580480267 4789 5280953 A monoamine oxidase inhibitor SGTC_1380 2291-0730 164 µM -2.81025090739474 0.0033240851927741 no 3310 0.00247514456858919 4778 2999191 SGTC_2194 5927483 104.545 µM -2.81463054557458 0.00328231815568356 no 3311 0.00244166695508446 4790 760979 SGTC_24 0417-1663 219 µM -2.81468794339094 0.00328177392065513 no 3312 0.00244123094312383 4790 4329390 SGTC_1294 1000-1494 117 µM -2.82929508441023 0.00314588158442717 no 3313 0.002332533190237 4790 712797 YDL207W GLE1 SGTC_3333 9141820 12.094 µM -2.85049554760138 0.00295765394313344 no 3314 0.00218255807588413 4764 1939433 SGTC_164 4100-3994 89.624 µM -2.85978499205174 0.00287842418480618 no 3315 0.00211964158972466 4762 4615967 SGTC_1844 rapamycin 4 nM -2.8680071455138 0.00280989955274376 no 3316 0.00206533102127043 4682 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_362 0310-0100 9.03 µM -2.89477512508702 0.0025968865934778 no 3317 0.00189715121427299 4779 790235 SGTC_1795 st049545 62.3 µM -2.90716624891819 0.00250331337359672 no 3318 0.00182359653103554 4784 5291882 SGTC_1628 st004252 77.7 µM -2.91005527591566 0.00248193955418443 no 3319 0.00180682419570001 4782 692968 SGTC_2126 5251174 33.877 µM -2.93088216716414 0.00233267593240283 no 3320 0.00169000480898287 4772 790722 SGTC_2998 9066762 71.4286 µM -2.94355262305405 0.0022458931806669 no 3321 0.00162234328228599 4768 4945196 SGTC_153 4077-0274 519.67 µM -2.95381065798067 0.00217778806167065 no 3322 0.00156938258552732 4779 3121976 SGTC_1036 k216-0215 33.5 µM -2.97299383574415 0.0020554302623919 no 3323 0.00147455187026554 4775 622330 SGTC_1626 st003712 1.76 µM -3.02341861665065 0.00176297746234461 no 3324 0.0012496812192097 4783 24207035 SGTC_537 1334-0398 209 µM -3.0410635533971 0.00166994186112133 no 3325 0.00117872032642037 4794 5846986 SGTC_2515 chrysin 20.77 µM -3.12438843571066 0.00128814172402693 no 3326 0.000890875371389645 4800 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1998 st075797 76.8 µM -3.12822344198463 0.00127266269255231 no 3327 0.000879332145272783 4792 24208315 SGTC_2021 4019055 173 µM -3.13838627330593 0.00123246214769896 no 3328 0.000849404216930167 4716 44827708 YER133W GLC7 SGTC_1574 spiramycin 23.7 µM -3.15728521169397 0.00116077946000944 no 3329 0.000796227526957418 4785 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2752 diclazuril 33.15 µM -3.16204805977812 0.00114332698679097 no 3330 0.00078331853087889 4764 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1837 st055472 66.5 µM -3.17501023275607 0.00109703995696284 no 3331 0.000749156087366477 4797 676091 SGTC_989 1501-0895 10.3 µM -3.1768506565442 0.00109060900444447 no 3332 0.000744418410996145 4789 2830112 SGTC_92 0063-0024 660.874 µM -3.23095685946483 0.000916312408427479 yes 3333 0.0006168827988639 4799 3594437 SGTC_855 0428-0020 25 µM -3.3235458913921 0.00067626169051126 yes 3334 0.000444403987307831 4805 6812414 SGTC_2896 9052656 71.43 µM -3.36056910674745 0.000597682882685624 yes 3335 0.000388910346414456 4556 6469436 SGTC_3259 9138485 49.47 µM -3.37015613802416 0.000578757861569455 yes 3336 0.000375628013827989 4790 17646153 SGTC_972 1319-0219 195 µM -3.37444217941268 0.000570477583129132 yes 3337 0.000369827262602686 4804 23903702 SGTC_2679 rapamycin 1 nM -3.3758130969294 0.000567852286601015 yes 3338 0.000367989489610105 4721 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1312 1218-2183 165 µM -3.38363146033972 0.000553092434981193 yes 3339 0.000357669763696562 4805 6744073 SGTC_3281 9140613 49.47 µM -3.43156614471277 0.000470084543354112 yes 3340 0.000300053382945715 4789 16013766 SGTC_1406 3909-7906 11.9 µM -3.51935137325534 0.000347235570905308 yes 3341 0.000216301673725188 4804 X1406 SGTC_971 1315-0384 26.7 µM -3.54890379872244 0.000313105988546381 yes 3342 0.000193419189617336 4806 6769120 SGTC_1718 roemerine 11.9335 µM -3.55582627856706 0.000305575822805444 yes 3343 0.0001883965012263 4638 235224 An aporphine alkaloid with mutagenic activity. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -3.55671052968979 0.00030462618023318 yes 3344 0.000187763776319099 4790 6708760 SGTC_3216 9129716 49.47 µM -3.63834194404316 0.000227885966857836 yes 3345 0.000137199473448819 4776 8056934 SGTC_2725 haloperidol 53.21 µM -3.73159433415219 0.000162432065452149 yes 3346 9.51358661617988e-05 4800 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_462 ag-879 158 µM -3.78550502061875 0.00013309904850745 yes 3347 7.6698368495365e-05 4803 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_827 3253-0474 693 µM -3.7897241122931 0.00013102664305709 yes 3348 7.54073461061118e-05 4808 5402065 SGTC_1306 1185-0270 9.02 µM -4.09425138168555 4.05273796644423e-05 yes 3349 2.11767301035295e-05 4810 1548076 SGTC_1635 st007035 42.4 µM -4.13371564595262 3.46056328519784e-05 yes 3350 1.78472530753331e-05 4795 3716403 SGTC_2358 9037157 4 µM -4.3845047119489 1.22861301549619e-05 yes 3351 5.81249833768282e-06 4807 2388925 SGTC_2131 toluylene red 5.2905 µM -4.53958693989771 6.30038760944719e-06 yes 3352 2.81822683069311e-06 4803 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2511 berberine 10.47 µM -5.00792152770996 7.37570822854322e-07 yes 3353 2.75104783974898e-07 4808 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1951 sophoraflavanone G 9.2 µM -8.05131452113702 5.65697849038894e-15 yes 3354 4.09547378275498e-16 4807 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.