SGTCid condition conc unit YAP7|YOL028C.score YAP7|YOL028C.strain.pval YAP7|YOL028C.strain.significant YAP7|YOL028C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_913 3487-1245 167 µM 5.55298661937331 2.71927115101297e-08 yes 1 1.40414789792101e-08 4 4016153 SGTC_919 tnp00227 403.569 nM 5.33828895371357 8.66721915738005e-08 yes 2 4.69139200099122e-08 10 1269246 A methoxyflavone. YNL221C POP1 SGTC_61 0978-8327 98.565 µM 4.16901243792646 2.25602917845488e-05 yes 3 1.52961148054515e-05 28 6150059 YHR072W ERG7 SGTC_2423 st077119 87.2 µM 3.83411635470881 8.79787458570949e-05 yes 4 6.30082421004721e-05 13 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2700 st077718 96.8 µM 3.81608451383148 9.43926739012618e-05 yes 5 6.77930404315675e-05 15 904970 SGTC_561 1550-0330 72.9 µM 3.78251087480168 0.000107521759982556 yes 6 7.76271540834305e-05 11 6812934 SGTC_3140 9094243 49.47 µM 3.69047905958999 0.000152843876925818 yes 7 0.000111916057664894 30 19291112 SGTC_2011 4012611 177 µM 3.67720507217833 0.000160695532845821 yes 8 0.000117901732790512 39 2049887 SGTC_910 3454-3003 490 µM 3.58078863022752 0.000230114002503846 yes 9 0.000171279348373077 27 820824 SGTC_2150 5556613 200 µM 3.57601088404705 0.00023419364516988 yes 10 0.000174438566243655 25 743190 SGTC_1339 1486-1321 22.7 µM 3.57564270169311 0.000234510814322976 yes 11 0.000174684269990357 36 3469382 SGTC_2325 6158266 200 µM 3.51349252504977 0.000294181572781932 yes 12 0.00022112842858862 39 3623240 SGTC_2418 pentamidine 31.67 µM 3.50443826540128 0.000303970648055441 yes 13 0.000228785822013053 62 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_233 rapamycin 362 pM 3.45877507239404 0.000358127096684139 yes 14 0.000271318929435077 22 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2130 NSC 7 2.4545 µM 3.42578082045022 0.00040269656199856 yes 15 0.000306517427616208 52 21448 SGTC_1363 1636-0063 10.4 µM 3.42089442826012 0.000409718769603976 yes 16 0.000312077779543607 48 6072185 SGTC_1407 3909-7909 12.3 µM 3.26835150499386 0.000695291236722981 yes 17 0.000540879629229585 38 4411780 SGTC_24 0417-1663 219 µM 3.21976163958353 0.000819253067013287 yes 18 0.000641486123846859 40 4329390 SGTC_1524 corynanthine 62.1 µM 3.21381804472006 0.000835738591701708 yes 19 0.000654913239342934 46 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1045 1348-1485 165 µM 3.17977414231624 0.000936191332420943 yes 20 0.000736949405967081 75 6810614 SGTC_3159 9100096 49.47 µM 3.14134727429998 0.00106282810968751 no 21 0.000840862468780483 51 25236875 SGTC_3058 9093861 49.47 µM 3.0975542745804 0.00122618395907985 no 22 0.000975623312415605 54 17217477 SGTC_46 0329-0187a 2.197 µM 3.06503512391097 0.00136201387639718 no 23 0.00108822217721581 130 46494817 SGTC_1839 st053978 48 µM 3.03285195678274 0.00150984427661961 no 24 0.00121127207290254 55 3788398 SGTC_196 k015-0023 18.111 µM 2.99796758041571 0.00168649685494804 no 25 0.00135893291695284 58 5211998 SGTC_1478 0453-0656 35.7 µM 2.98577160462935 0.00175256608249975 no 26 0.00141431910436659 42 5258496 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.97822689094035 0.00179460846607789 no 27 0.00144960639470297 48 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3215 9129942 49.47 µM 2.94920537193616 0.00196501793337033 no 28 0.00159296092715323 39 17682944 SGTC_2815 7968870 71.43 µM 2.92710470253086 0.0021045050315449 no 29 0.00171066839525344 82 2977326 YHR190W ERG9 SGTC_2914 7968218 45.32 µM 2.89379940732682 0.00233172282510164 no 30 0.00190305613328394 40 2977111 SGTC_1124 fisetin 1.16336 µM 2.88487829083627 0.00239624496509719 no 31 0.00195782504489534 91 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2087 5276107 200 µM 2.87856846554695 0.00244285181264753 no 32 0.00199742278454281 75 144405 SGTC_197 4544-0043 41.561 µM 2.85443804889421 0.00262874851596556 no 33 0.00215565196804891 117 896523 SGTC_872 0588-0139 234 µM 2.8544224086666 0.00262887304090357 no 34 0.00215575810996916 94 2047100 SGTC_517 1365-0151 113 µM 2.83272511681763 0.00280684399969516 no 35 0.00230765277894162 90 768657 SGTC_3050 9093513 49.47 µM 2.77977205495241 0.00328767047081641 no 36 0.00271985335648863 72 25236664 SGTC_905 2-aminofluorene 215 µM 2.76572617767655 0.00342706524713699 no 37 0.00283981017260585 97 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1242 0402-0103 60.1 µM 2.75349857148189 0.00355271424852509 no 38 0.00294810137609998 86 432868 SGTC_54 0159-0055 9 µM 2.74151730438673 0.00367982802411513 no 39 0.00305780696745785 96 3319099 SGTC_3097 9117246 49.47 µM 2.73240395981991 0.00377923105112021 no 40 0.00314369995858229 80 16423892 SGTC_1940 st075990 51.1 µM 2.71475434373999 0.00397861390531078 no 41 0.00331624742693172 103 1084979 SGTC_2964 9083345 53.42 µM 2.68227797767123 0.00437024451426504 no 42 0.00365613356652018 88 17741579 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.68163953159256 0.00437827724575651 no 43 0.0036631177452749 77 6708784 An antioxidant flavonoid SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.66091283970204 0.00464632540430846 no 44 0.00389645635797765 79 689007 SGTC_7 0192-1582 4.227 µM 2.65470641164778 0.00472939054780996 no 45 0.00396887299115761 171 252616 SGTC_1193 1488-0126 41.5 µM 2.64980283158881 0.00479595266552987 no 46 0.00402693787459404 91 1384710 SGTC_1075 aripiprazole 15.2 µM 2.64961556946166 0.00479851107342272 no 47 0.00402917030628714 128 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1286 0929-0070 131 µM 2.635021352225 0.0050016815125818 no 48 0.00420659952784553 107 1420408 SGTC_1583 clindamycin 39.6 µM 2.63458180203224 0.00500791773508117 no 49 0.00421205011726974 90 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3091 9116372 49.47 µM 2.61958847816341 0.0052248288986316 no 50 0.00440179660051567 96 17169793 SGTC_1118 chelidonine 707.474 nM 2.61292465210822 0.00532389035890242 no 51 0.0044885545590163 97 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_404 fumagillin 50 µM 2.60503294701993 0.00544336249290116 no 52 0.00459327128375545 99 12015870 A methionine aminopeptidase binder. SGTC_86 0417-1630 471.922 µM 2.58539880822396 0.00575100186238001 no 53 0.0048633209695313 281 3634867 SGTC_2406 ethylparaben 405.7 µM 2.55558006102135 0.00624775737272143 no 54 0.00530054853383853 135 8434 A possible steroid mimic. SGTC_1956 st077085 54 µM 2.5447635761199 0.00643712928616627 no 55 0.0054675874425587 117 24208685 SGTC_664 1222-0054 14.9 µM 2.53836197197575 0.0065515835440503 no 56 0.0055686362869017 129 6813991 SGTC_1629 st005085 44.9 µM 2.53814726490274 0.0065554532888519 no 57 0.00557205398711037 137 24207091 SGTC_2539 epi(13)torulosol 80 µM 2.53787814684619 0.00656030655738552 no 58 0.00557634043070801 115 6708597 SGTC_278 4092-0821 23.9 µM 2.53075232277976 0.00668997471126204 no 59 0.00569090937117775 125 877900 SGTC_2324 6149169 200 µM 2.50747317828253 0.00712950901931388 no 60 0.00607989048773648 94 2888231 SGTC_1202 1988-0068 29.6 µM 2.49884772435549 0.00729872270682564 no 61 0.00622989187426359 135 2850480 SGTC_840 0245-0196 390 µM 2.49148666985181 0.00744592148762707 no 62 0.00636048702309248 112 3827528 SGTC_485 niflumic acid 177 µM 2.46655995187585 0.00796398672815525 no 63 0.00682089449391173 91 4488 A COX2 inhibitor. SGTC_2013 4024628 200 µM 2.44767277056914 0.00837737758119697 no 64 0.00718910863172208 162 5230760 SGTC_662 k832-1615 104 µM 2.44632449633486 0.00840759555498761 no 65 0.00721605211330146 125 5878478 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.44158916587554 0.00851448484376392 no 66 0.00731138839140075 159 6708561 SGTC_620 0109-0052 432 µM 2.44077041829387 0.00853308662254426 no 67 0.00732798433078342 105 493037 SGTC_247 mechlorethamine 29.705 µM 2.43718948067533 0.00861486446052919 no 68 0.00740096046532079 92 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2831 7999036 19.48 µM 2.42865706786816 0.0088124951116006 no 69 0.00757742960604663 183 2988270 SGTC_2084 5306078 60.6385 µM 2.42834324058009 0.0088198392462399 no 70 0.00758399030919173 130 679340 SGTC_43 0570-0105 72.5 µM 2.42553911087801 0.00888569949863184 no 71 0.00764283430698436 282 1114046 YDL195W SEC31 SGTC_194 1486-1323 56.904 µM 2.4020978886279 0.00945332733878792 no 72 0.00815067280391175 118 5178754 SGTC_1088 bifonazole 369 nM 2.38338134942455 0.00992906722330502 no 73 0.00857720670633104 107 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2486 5283202 22.39 µM 2.3492558981635 0.0108504496536055 no 74 0.0094054868729658 157 1377751 SGTC_178 4092-0806 87.505 µM 2.34247402224796 0.0110421733132345 no 75 0.0095781837526451 264 2169044 SGTC_3055 9094636 49.47 µM 2.33344600743716 0.0113019633343754 no 76 0.00981237448914507 119 25236176 SGTC_791 1348-1292 225 µM 2.32551650836579 0.0115345079951041 no 77 0.0100221791144386 209 5437054 SGTC_541 4513-1321 94 µM 2.32333310820953 0.0115992646839937 no 78 0.0100806322681455 140 747515 SGTC_77 0828-0286 12.516 µM 2.32138043476405 0.0116574454908547 no 79 0.0101331602695774 183 745345 SGTC_1028 k015-0029 4.8 µM 2.31740310189689 0.0117767359402859 no 80 0.0102408917679899 182 4588309 SGTC_2413 inermin 26.06 µM 2.31262481822447 0.0119214485214897 no 81 0.0103716378965396 201 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1062 mesoridazine 14.2 µM 2.304563205892 0.0121690957685456 no 82 0.0105955243213903 155 4078 A neuroleptic. SGTC_1006 4099-6547 255 µM 2.30326551246874 0.0122093738626647 no 83 0.0106319543996629 157 3146833 SGTC_1067 clotrimazole 1.36 µM 2.28843420077121 0.0126779793919504 no 84 0.0110561239289363 178 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1965 Pectolinarigenin 58.4 µM 2.28149570667252 0.012902497871474 no 85 0.0112595652379337 117 5320438 An anti-inflammatory. SGTC_2982 9019404 25.97 µM 2.27982620937816 0.0129570305260912 no 86 0.0113089989484582 154 22333232 SGTC_1446 4239-0190 62 µM 2.26971914649014 0.013291442519505 no 87 0.0116123144798337 187 1340085 SGTC_1053 3366-3204 134 µM 2.26401363261105 0.0134834929600154 no 88 0.0117866381596187 166 3632071 YPR165W RHO1 SGTC_3278 9139605 49.47 µM 2.2534785880998 0.0138444085224842 no 89 0.0121144946527311 138 7958859 SGTC_1351 1496-0003 46.5 µM 2.23776144475981 0.0143983308252612 no 90 0.012618307959784 146 3891978 SGTC_1636 st007707 68.9 µM 2.22105909224859 0.0150077855016387 no 91 0.0131734796399807 204 403051 SGTC_3106 9121286 49.47 µM 2.21494857868942 0.0152362276207397 no 92 0.0133817970983747 141 15943471 SGTC_2796 7949634 45.45 µM 2.21441951057835 0.0152561466483781 no 93 0.0133999669911556 176 2971588 SGTC_650 1328-0195 38 µM 2.20899444984923 0.0154616900825706 no 94 0.0135875134750174 177 2780821 SGTC_2715 st079500 56.4 µM 2.20787048626055 0.0155045705582247 no 95 0.0136266513756609 132 28246688 SGTC_3044 9093193 49.47 µM 2.20281964304732 0.0156985281656213 no 96 0.0138037315562587 199 25236277 SGTC_958 1222-0007 33 µM 2.19789389852061 0.0158896829890166 no 97 0.013978333906878 196 7312461 SGTC_3334 9142812 21.919 µM 2.19504727132928 0.0160010602362162 no 98 0.0140801035006599 161 45283678 SGTC_1665 st014639 11.4 µM 2.18703820978341 0.0163180196647023 no 99 0.0143698673713293 190 981133 YIL048W NEO1 SGTC_1744 st037937 38.9 µM 2.18087242070378 0.0165656806035014 no 100 0.0145964270584348 185 1016152 SGTC_228 caffeine 993.056 µM 2.17555168789963 0.0167819772488281 no 101 0.0147943995966374 125 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1600 coumarin 106 71.1 µM 2.15509697497502 0.0176361318131473 no 102 0.0155771231982431 195 100336 A hepatotoxic, DNA x-linker. SGTC_303 1348-1668 34.2 µM 2.15348733613476 0.0177048950715332 no 103 0.0156401991525489 142 5380509 SGTC_2639 lactacystin 53 µM 2.1523107688782 0.0177553022610369 no 104 0.0156864431136431 192 3870 A proteasome inhibitor. SGTC_835 0312-0010 67.2 µM 2.14948180903101 0.0178770035965871 no 105 0.0157981132853435 152 1626196 SGTC_2532 xanthone 78.9 µM 2.13126387347192 0.0186779021675352 no 106 0.0165337047560222 186 7020 An insecticide. SGTC_1848 st056003 16.4 µM 2.11672296548616 0.0193388803452005 no 107 0.0171416832894591 173 146492 SGTC_136 0097-0015 404.482 µM 2.1143454979929 0.0194488203460583 no 108 0.0172428845147263 199 4861337 SGTC_1959 st077091 55.8 µM 2.11051398575395 0.0196271161879738 no 109 0.0174070538984159 221 821356 YKL052C ASK1 SGTC_3338 9144300 39.5675 µM 2.10935696428472 0.019681229186677 no 110 0.0174568906197219 195 4901274 SGTC_610 4215-0184 155 µM 2.10111312952474 0.0200704652524814 no 111 0.0178155183121651 204 5605015 SGTC_2951 9072950 58.06 µM 2.09791318460418 0.0202233012937725 no 112 0.0179564075520246 216 16488155 SGTC_3117 9124945 49.47 µM 2.09175945797421 0.0205199905883726 no 113 0.0182300193592669 143 17592065 SGTC_258 haloperidol 50.781 µM 2.07382513557842 0.0214057712487934 no 114 0.0190477769370699 244 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2380 9035439 200 µM 2.06213615841813 0.0220003243852848 no 115 0.0195973873545828 223 6462575 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.06206330378869 0.022004073373912 no 116 0.0196008547367661 208 688801 SGTC_583 1488-1091 88.9 µM 2.04352248536653 0.0229758500893953 no 117 0.0205003719125677 251 4303273 SGTC_1342 1486-1464 234 µM 2.03707636129969 0.0233220703086953 no 118 0.0208211951738553 196 3253938 SGTC_3183 9108214 49.47 µM 2.03661875224719 0.0233468144466717 no 119 0.0208441310592524 77 4974831 SGTC_957 1187-1561 14.1 µM 2.0312087534148 0.023641025787409 no 120 0.0211169114034114 233 1538454 SGTC_581 0958-0271 211 µM 2.02463446914295 0.0240027451076612 no 121 0.0214524560547009 289 4591145 SGTC_530 4358-1714 28 µM 2.02417633581154 0.0240281241569746 no 122 0.0214760057559712 260 1564641 SGTC_2985 9022375 71.43 µM 2.02254528681866 0.0241186619007353 no 123 0.0215600250080582 229 4939335 SGTC_777 1315-0167 517 µM 2.01746424182561 0.0244025440411721 no 124 0.0218235445117877 205 4221767 SGTC_1983 st071813 46.9 µM 2.01099321958481 0.0247681415544757 no 125 0.0221630864548328 198 11838595 SGTC_564 3555-0129 330 µM 2.00902244452812 0.024880394275861 no 126 0.0222673767583525 134 563260 SGTC_2827 7993847 71.43 µM 2.00743242806332 0.0249712701702711 no 127 0.0223518194178946 178 2985692 SGTC_2636 apigenin dimethyl ether 100 µM 2.00709946395213 0.0249903356198334 no 128 0.0223695366530212 269 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3181 9108277 49.47 µM 1.99798707969497 0.0255168650951197 no 129 0.02285903044441 209 17097298 SGTC_1029 k015-0030 64.7 µM 1.99193970508732 0.0258713964007184 no 130 0.0231888369206048 239 2208316 SGTC_756 0508-1999 28.3 µM 1.97779273870751 0.0267168951913029 no 131 0.0239760464972589 219 6753853 SGTC_49 0717-0965 32.132 µM 1.97350789621627 0.0269774887370044 no 132 0.0242188629140747 245 5889349 YGL099W LSG1 SGTC_1850 st056238 17 µM 1.9702718823507 0.0271756983572433 no 133 0.0244036095631924 241 5393177 SGTC_26 0302-0163 425.158 µM 1.95416701743401 0.0281802951647401 no 134 0.0253407342639714 190 3100915 SGTC_710 3448-4187 58 µM 1.95322024435107 0.0282403031312955 no 135 0.0253967516225896 336 3946412 SGTC_3194 9111903 49.47 µM 1.94955118684558 0.0284738594416852 no 136 0.025614818116419 231 17087251 SGTC_1899 st063254 59.6 µM 1.94629035537384 0.0286827764917248 no 137 0.025809935732103 193 3093813 SGTC_44 0929-0055 61.211 µM 1.94010062298228 0.0290828508720569 no 138 0.0261837311646939 217 1379590 SGTC_1094 duloxetine 25.4 µM 1.93791890032965 0.0292249674597313 no 139 0.0263165588431726 239 60834 A selective serotonin reuptake inhibitor. SGTC_1345 1488-0192 31.4 µM 1.93304778961586 0.0295443522421099 no 140 0.0266151554600569 233 658348 SGTC_96 0929-0093 37.281 µM 1.91581293825839 0.0306977367299146 no 141 0.0276944551419618 233 6991579 SGTC_1443 4112-3303 14 µM 1.9100921336216 0.031088728178984 no 142 0.0280606758342708 246 704433 SGTC_2620 irigenin 100 µM 1.90901361554743 0.031162899731953 no 143 0.0281301676321127 280 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3166 9102297 49.47 µM 1.9086965793613 0.0311847306776429 no 144 0.0281506223488974 277 25237072 SGTC_1835 st008666 49.2 µM 1.89950813249006 0.0318229591876544 no 145 0.0287488491877643 201 690455 SGTC_2496 diffractaic acid 79.83 µM 1.89734822550017 0.031974542168093 no 146 0.0288909970269575 262 94870 An apoptosis inducer which activates caspases. SGTC_836 0330-0104 1.35 µM 1.89638485876715 0.0320423435888217 no 147 0.0289545862744023 237 46494820 SGTC_459 nigericin 15.3 µM 1.89311837053646 0.0322731221278334 no 148 0.0291710648379542 307 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1084 voriconazole 435 nM 1.88485419040012 0.0328631202723863 no 149 0.0297247631634669 226 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1698 5-fluorocytosine 1.055 µM 1.88218547502637 0.0330555343503337 no 150 0.0299054185446211 216 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3033 9090887 49.47 µM 1.87843139459363 0.0333277735788231 no 151 0.0301610870471842 287 19325384 SGTC_2623 humulene 100 µM 1.87038838990518 0.0339172557846096 no 152 0.0307149515234771 202 6187145 An anti-inflammatory. SGTC_349 k015-0014 24 µM 1.86678222931761 0.034184326666458 no 153 0.0309660025530234 249 2196908 SGTC_2165 5727197 32.143 µM 1.86411364821197 0.0343830717916016 no 154 0.0311528731505619 292 1361712 SGTC_786 4544-0069 423 µM 1.86248111212456 0.0345051239076604 no 155 0.0312676526790074 300 748821 YLR208W SEC13 SGTC_3210 9128157 49.47 µM 1.86247126098113 0.034505861480562 no 156 0.0312683463484272 304 17590849 SGTC_2711 st079103 59.1 µM 1.85849045445721 0.0348049735443589 no 157 0.0315496988403861 210 54693780 SGTC_1547 harmine 94.2 µM 1.8433116643529 0.0359650799582563 no 158 0.032641759531371 336 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3127 9126946 49.47 µM 1.84088031004233 0.0361538174065237 no 159 0.0328195502203583 243 27243249 SGTC_1340 1486-1359 257 µM 1.84070462613357 0.036167486487046 no 160 0.0328324278210544 270 4309068 SGTC_2401 5128683 200 µM 1.82425144513272 0.0374665032340105 no 161 0.03405703364986 271 708373 SGTC_1128 3448-9350 235 µM 1.81980715532005 0.0378238527788157 no 162 0.0343941888481914 274 619386 SGTC_1611 st001856 99.4 µM 1.80162379330273 0.0393149904957285 no 163 0.0358023075998696 283 647478 SGTC_256 clotrimazole 625 nM 1.80074707013997 0.0393880786504582 no 164 0.0358713774516795 299 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1126 isoteolin 1.0172 µM 1.79351799882799 0.0399949539371283 no 165 0.0364450676384342 298 133323 SGTC_235 0330-0087 5 mM 1.79269185186156 0.0400647895996383 no 166 0.0365111050601012 317 46494818 YHR062C RPP1 SGTC_870 0573-2213 57.6 µM 1.77723574801048 0.0413896848814938 no 167 0.0377647300412467 252 3916321 SGTC_725 1497-0963 19 µM 1.772878315985 0.041769553123748 no 168 0.0381244362504788 275 3549977 SGTC_297 0986-0032 24 µM 1.76931307617545 0.0420824562247026 no 169 0.038420821229623 257 2847425 SGTC_2804 7954240 19.48 µM 1.76697872450737 0.0422883562980118 no 170 0.0386158957147169 326 828705 SGTC_3327 9140648 26.9345 µM 1.7669265635017 0.0422929664209282 no 171 0.038620263848395 274 8029710 SGTC_2236 dapsone 200 µM 1.76293994706269 0.0426465186280991 no 172 0.0389553093369754 295 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_948 3448-0295 75.3 µM 1.76001732105931 0.0429072260841645 no 173 0.0392024348934822 342 678569 SGTC_213 1246-0773 967 nM 1.75912066021324 0.0429874687405587 no 174 0.0392785082211721 319 6251622 SGTC_2269 7935389 174.42 µM 1.75301927728942 0.0435367093370833 no 175 0.0397993490919313 300 97605 SGTC_1833 st055984 71 µM 1.75230956675396 0.0436009628979694 no 176 0.0398602959565371 277 676288 SGTC_2148 5546263 113.568 µM 1.75141589309917 0.0436819803702723 no 177 0.0399371486634381 302 792097 SGTC_3164 9100705 49.47 µM 1.74748783647556 0.044039526339592 no 178 0.0402763764989158 222 17174235 SGTC_1761 st044296 37 µM 1.74657301210819 0.044123134864599 no 179 0.0403557159887761 299 1826700 SGTC_3322 9139058 2.11 µM 1.74448808755643 0.0443141605335467 no 180 0.0405370084136657 302 4908926 YPR165W RHO1 SGTC_1437 4092-1038 11.6 µM 1.74439052020826 0.0443231161822748 no 181 0.0405455084472543 318 3977136 SGTC_2558 carylophyllene oxide 100 µM 1.74326227716362 0.0444267829316534 no 182 0.0406439057305233 313 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1935 st074532 41.6 µM 1.74113048693804 0.0446231922278706 no 183 0.0408303542418995 374 2829742 SGTC_2312 7706453 155.7 µM 1.73805245800303 0.0449080151323009 no 184 0.0411007854456643 324 976098 SGTC_175 3793-3120 23.7 µM 1.73797250932679 0.0449154325732007 no 185 0.0411078289276795 291 5322297 SGTC_1993 st073995 70.8 µM 1.73105782199289 0.0455607007309314 no 186 0.0417207260318614 294 3098394 SGTC_379 3970-0972 5.9 µM 1.72755062504856 0.0458908245912345 no 187 0.0420344107327957 324 2898042 YBL034C STU1 SGTC_2811 7967822 32.47 µM 1.72667879382097 0.0459731855106585 no 188 0.0421126831115225 323 2232244 SGTC_1492 4158-0558 28.5 µM 1.72389366557903 0.046237089378577 no 189 0.0423635205357735 291 3967268 SGTC_1737 st035557 69.7 µM 1.72352240177758 0.0462723600592707 no 190 0.0423970488288048 258 5716916 SGTC_449 xestospongin c 11.1929 µM 1.723438815634 0.0462803038611318 no 191 0.0424046003310985 345 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2210 7115885 190.385 µM 1.72117628563602 0.0464957449023309 no 192 0.0426094198449247 299 2927039 SGTC_293 4049-0273 38.5 µM 1.71647490397915 0.0469459905854674 no 193 0.0430375786934062 272 1380311 SGTC_1493 4348-0038 111 µM 1.71555688012421 0.0470343153421535 no 194 0.0431215881726192 345 800424 SGTC_694 1315-0438 43.2 µM 1.71415515477291 0.0471694348994453 no 195 0.0432501172543893 271 6793154 SGTC_3289 9119912 71.43 µM 1.71018520444759 0.0475538081158241 no 196 0.0436158153926751 322 17014829 SGTC_1759 st043059 70 µM 1.70914074126244 0.0476553495167698 no 197 0.0437124412276068 354 669426 SGTC_1530 rhein 70.4 µM 1.70863028078813 0.0477050389781659 no 198 0.0437597279644847 336 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2231 micatex 6.853 µM 1.70700626619611 0.0478634005302321 no 199 0.0439104438566481 264 20737 An antifungal of unknown mechanism. SGTC_837 0091-0265 12.5 µM 1.70384099152203 0.0481732634167823 no 200 0.0442053987681326 326 759367 SGTC_1649 st011737 51.3 µM 1.70355179429251 0.0482016540662472 no 201 0.0442324269389115 309 1761035 SGTC_602 3130-1533 38.1 µM 1.7033661670861 0.0482198842430603 no 202 0.0442497825457682 364 720941 SGTC_856 0433-0016 11.3 µM 1.70014770279331 0.0485368427268317 no 203 0.0445515731910281 330 3911780 SGTC_1092 toremifene 6.32 µM 1.69639436901848 0.0489085776126817 no 204 0.0449056097025445 376 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2968 9090663 33.37 µM 1.69203299502111 0.0493433873048831 no 205 0.0453198413584732 342 25236811 SGTC_89 0302-0250 142.109 µM 1.6896628562085 0.0495809707751348 no 206 0.0455462366052418 358 4203518 YLR208W SEC13 SGTC_1667 st014849 34.6 µM 1.68843655607707 0.049704253363883 no 207 0.0456637290486301 307 5348460 SGTC_3355 9151058 44.0485 µM 1.68152768693243 0.050403393864225 no 208 0.0463302316203684 311 17015728 SGTC_2072 5231554 129 µM 1.67873455129045 0.050688259192152 no 209 0.0466018945043228 303 789545 SGTC_1420 4'-methoxyflavone 42 µM 1.67863336304694 0.0506986031604288 no 210 0.0466117601060404 297 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2241 6772625 37.8075 µM 1.67702080691948 0.0508636736827659 no 211 0.0467692065962272 331 2285411 SGTC_3285 9112818 20.8695 µM 1.6758795336292 0.0509807593583383 no 212 0.0468808956626348 355 17017947 YPR165W RHO1 SGTC_738 1315-0003 72.4 µM 1.67413557928607 0.0511600896566237 no 213 0.0470519783451714 346 6251474 SGTC_3072 9116419 49.47 µM 1.67038950385172 0.0515469945028977 no 214 0.0474211624812538 308 17170162 SGTC_2184 6075246 200 µM 1.66669584148566 0.051930760472377 no 215 0.0477874501158556 332 2267320 SGTC_3086 9117350 49.47 µM 1.66424351330249 0.0521868052789031 no 216 0.048031887803278 216 2679265 SGTC_2330 7979373 200 µM 1.65765263620008 0.0528799215875649 no 217 0.0486937994687491 375 1863007 SGTC_25 0118-0223 35.662 µM 1.65562609628339 0.0530945001667662 no 218 0.0488987810061543 328 5333628 SGTC_553 k007-0256 45.7 µM 1.65502695161354 0.0531580721884729 no 219 0.0489595154894312 358 6287000 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.65115522039178 0.0535703369734447 no 220 0.0493534420548918 375 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1994 st072947 40.9 µM 1.64945254669938 0.0537524389733682 no 221 0.0495274785946449 343 5286565 YDL195W SEC31 SGTC_343 4130-2827 29.8 µM 1.64933277038515 0.0537652675577986 no 222 0.0495397397890911 363 1118244 SGTC_2233 sulbentine 40.3845 µM 1.64764289158579 0.0539465197560121 no 223 0.0497129866806015 403 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1963 st076565 50.3 µM 1.64232921883218 0.0545196045759048 no 224 0.0502608974561707 337 4914280 SGTC_14 0354-0009 295 µM 1.64127268115256 0.0546341249972084 no 225 0.0503704121649465 360 1713507 SGTC_2136 5328288 199.296 µM 1.63891043947659 0.0548908615546997 no 226 0.0506159566190167 293 262395 SGTC_2710 st078562 53.7235 µM 1.63844779008083 0.0549412553660945 no 227 0.0506641584199381 322 17250908 SGTC_1662 st014054 52 µM 1.6362929620865 0.0551764506058957 no 228 0.0508891441774192 285 2838777 SGTC_648 0375-0473 33.3 µM 1.63061402200472 0.055800106595811 no 229 0.0514858942829496 395 1713139 SGTC_81 0411-0046 9.971 µM 1.62872338916348 0.0560089638494871 no 230 0.0516857945459318 323 12925265 SGTC_1106 tegaserod maleate 11.7 µM 1.62706362591442 0.056192824864972 no 231 0.0518617926584017 391 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_428 3448-4153 16.5 µM 1.62051547511676 0.0569228454301917 no 232 0.0525607964080425 334 3834874 SGTC_2541 muurolladie-3-one 83.07 µM 1.62046589490994 0.056928401230465 no 233 0.0525661173914368 359 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2903 5923464 63.88 µM 1.61823275902486 0.0571790823560482 no 234 0.0528062227415063 297 2876576 SGTC_3349 9149703 23.001 µM 1.60872690389718 0.0582558973608452 no 235 0.0538380351316575 332 4910494 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.6084120618518 0.0582918330889637 no 236 0.0538724808482424 402 5106787 A p450 inhibitor. SGTC_2365 9042475 200 µM 1.60715366266913 0.0584356393124172 no 237 0.0540103319882743 387 6464479 SGTC_2594 a-mangostin 100 µM 1.60475461648852 0.0587105670922843 no 238 0.0542739085832748 403 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_522 1273-0010 11.6 µM 1.60364378670734 0.0588382102418206 no 239 0.054396296613637 350 5705015 SGTC_2043 5101342 149 µM 1.59135486309681 0.0602648779971746 no 240 0.0557648681520379 390 678451 SGTC_2926 9010726 65.15 µM 1.59068246803501 0.0603437134295318 no 241 0.0558405272242041 389 2994293 SGTC_2151 5563267 85.4165 µM 1.58628596131183 0.0608611757819235 no 242 0.0563372277206098 392 5310824 SGTC_925 2064-1272 59.6 µM 1.58300542824678 0.0612495450681233 no 243 0.0567101135791002 361 6815817 SGTC_3148 9097893 49.47 µM 1.58256298668843 0.0613020718330069 no 244 0.0567605526928004 379 17174100 SGTC_2687 chenodiol 100 µM 1.58029252266796 0.0615721757515746 no 245 0.0570199457278884 358 5702181 A cholesterol synthesis inhibitor. SGTC_1169 aniline yellow 25.8 µM 1.57924225905543 0.0616974334869871 no 246 0.0571402501645292 331 6051 A DNA damaging agent. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.57912363263981 0.0617115937411462 no 247 0.057153851000644 385 165521 SGTC_3112 9123419 49.47 µM 1.57734657056159 0.0619240227645397 no 248 0.0573579010710358 409 17015854 SGTC_901 1112-0062 60.1 µM 1.57705603410397 0.0619588075469744 no 249 0.0573913161935018 350 1908457 SGTC_1096 rimcazole 32.2 µM 1.57574592751984 0.0621158508736883 no 250 0.0575421841994383 340 18528119 A dopamine reuptake inhibitor. SGTC_524 r073-0010 27.8 µM 1.57179496179956 0.0625913365207522 no 251 0.0579990551811131 374 2772106 SGTC_2147 5545932 89.7195 µM 1.56988670776871 0.0628220023607561 no 252 0.0582207352493456 355 797404 SGTC_2262 9014885 67.46 µM 1.56480517819492 0.0634394779251666 no 253 0.0588142986147013 268 6457424 SGTC_726 3448-4391 34.2 µM 1.56216609830701 0.0637620207210857 no 254 0.0591244324166522 413 1356692 SGTC_2674 ligustilide 100 µM 1.55536770102516 0.064598782570337 no 255 0.0599292609606724 349 5319022 A signalling regulator. SGTC_790 1575-0012 79.1 µM 1.55320161508881 0.0648671734420899 no 256 0.0601874878065917 403 378741 YLR208W SEC13 SGTC_368 fentichlor 4.58 µM 1.55092513687858 0.0651501747689131 no 257 0.0604598128301846 346 7329 A pesticide. SGTC_1235 benzylparaben 21.5 µM 1.55054936778565 0.0651969806463921 no 258 0.0605048569884038 371 7180 SGTC_3110 9122132 49.47 µM 1.54963702088712 0.0653107313464049 no 259 0.0606143310180371 388 918317 SGTC_2179 6298986 200 µM 1.54801054549001 0.0655139008502421 no 260 0.0608098787855771 348 738374 SGTC_1511 0906-3109 28.5 µM 1.54799784165543 0.0655154896635366 no 261 0.0608114080805968 517 2882180 SGTC_87 0100-0052 35.5 µM 1.54625836131826 0.0657333211853415 no 262 0.0610210918743876 635 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3001 9076041 71.4286 µM 1.54578161484199 0.065793121077478 no 263 0.0610786593317392 377 16004211 SGTC_1187 1391-0724 117 µM 1.54313235344364 0.0661261952489431 no 264 0.061399333112322 437 6997986 SGTC_3356 9151811 4.48 µM 1.54294063545738 0.0661503492782835 no 265 0.0614225901115314 386 1859254 YPR165W RHO1 SGTC_3213 9129884 49.47 µM 1.54246849252598 0.0662098624260185 no 266 0.0614798943479068 338 17190742 SGTC_1666 st014829 29 µM 1.53825670952736 0.0667425899978636 no 267 0.0619929300113925 431 3858230 SGTC_2235 salicylic acid 500 µM 1.53586325423709 0.067046800890648 no 268 0.0622859610177278 340 338 A COX inhibitor and kinase inhibitor. SGTC_1164 k060-0068 93.7 µM 1.53549347285492 0.0670938960125163 no 269 0.0623313295810972 435 5963676 SGTC_1197 1601-0112 267 µM 1.53293834669138 0.0674200146689259 no 270 0.0626455232220192 437 7350313 SGTC_3078 9116413 49.47 µM 1.52765286892203 0.0680985034677948 no 271 0.0632993738973873 373 17177322 SGTC_795 0685-0265 78 µM 1.5231889779669 0.0686756218215464 no 272 0.0638557164174131 432 302754 SGTC_2760 etidronate 98.04 µM 1.5231644419092 0.0686788043795116 no 273 0.0638587848645049 413 3305 A chelator and antioxidant. SGTC_1398 3558-0053 112 µM 1.52063858310007 0.0690070410065834 no 274 0.0641752794443373 331 4532369 SGTC_2263 7948595 193.29 µM 1.51709783990744 0.0694691960907437 no 275 0.0646209917784149 327 2971371 SGTC_1483 3453-0561 55.9 µM 1.51673681923769 0.0695164518627163 no 276 0.0646665721690957 452 4546991 SGTC_2581 avocatin a 64 µM 1.51446401661925 0.0698145188252759 no 277 0.0649540967671902 466 6710728 A skin care supplement. SGTC_1226 3909-7979 35.4 µM 1.51364946756228 0.0699215820601243 no 278 0.0650573838423842 473 6615510 SGTC_794 k038-0031 316 µM 1.50228143155345 0.0714289987922883 no 279 0.0665122210163097 523 6624242 SGTC_1356 1502-0781 85.8 µM 1.50171162889032 0.0715052067146376 no 280 0.0665857996581505 408 567702 SGTC_2697 mebhydrolin 72.4 µM 1.49957450477942 0.0717915910595571 no 281 0.0668623279753727 491 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1675 st018485 24.5 µM 1.49143233658718 0.0728907439005704 no 282 0.0679240117866776 417 3323024 SGTC_1616 st002734 56.1 µM 1.48785069625248 0.0733783083823573 no 283 0.0683951362738923 453 4026101 SGTC_1168 k815-0004 80.5 µM 1.48550226645038 0.0736993488303639 no 284 0.0687054117325653 424 642433 SGTC_1612 st002233 45.4 µM 1.47563804427501 0.0750595669265828 no 285 0.0700205431486444 429 1035021 SGTC_3016 9080866 49.47 µM 1.47450878764843 0.0752164981985189 no 286 0.0701723267119786 452 17066299 SGTC_2331 7980721 200 µM 1.47297253758216 0.075430390275493 no 287 0.0703792204907923 443 2981221 SGTC_1296 1068-0102 11.9 µM 1.4715945081485 0.0756226474190623 no 288 0.0705652047392426 429 767053 SGTC_1915 st067105 30.6 µM 1.47023545612136 0.0758126223496738 no 289 0.0707489974978307 455 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_42 0133-0086 60.653 µM 1.46810115320062 0.0761116989664014 no 290 0.0710383741992588 401 162923 Model of phenazepam hydroxylation. SGTC_3076 9116187 49.47 µM 1.46652463558091 0.0763331900786128 no 291 0.0712527073699135 404 27241210 SGTC_2056 5235370 200 µM 1.46091274059526 0.0771256085305762 no 292 0.072019694863511 463 5511916 SGTC_2311 7694451 200 µM 1.45779229018709 0.0775689225469168 no 293 0.0724489020158755 440 2163142 SGTC_1315 1237-0019 3.69 µM 1.4565040098519 0.0777525083379905 no 294 0.072626670972993 451 825140 SGTC_1550 gossypolone 36.6 µM 1.45537331410309 0.0779139092091483 no 295 0.0727829700390165 460 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_257 daunorubicin 18.5 µM 1.45528880770698 0.0779259822560637 no 296 0.0727946619173797 389 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3282 9108498 15.4605 µM 1.45442246305621 0.0780498348888608 no 297 0.0729146079425454 465 16459645 SGTC_2825 7998094 58.44 µM 1.45288982108887 0.0782693070959428 no 298 0.0731271737850203 432 2987815 SGTC_174 3553-0389 74.3 µM 1.45242914310415 0.0783353669419975 no 299 0.0731911589318321 395 738071 SGTC_2784 7567673 72.73 µM 1.45073025011015 0.0785793485978032 no 300 0.0734274943194314 484 3471247 SGTC_1966 st070145 16.1 µM 1.45053466574623 0.0786074738173534 no 301 0.0734547397554056 443 3748532 SGTC_1331 1472-0049 76.2 µM 1.44843526296848 0.0789098506197931 no 302 0.0737476793804037 431 24051409 SGTC_1733 st037357 54.9 µM 1.44745070933706 0.0790519589344789 no 303 0.0738853660285809 489 1272339 YGL099W LSG1 SGTC_2020 4017018 200 µM 1.44459156419467 0.0794657403681139 no 304 0.07428632184281 450 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_826 1683-5028 118 µM 1.44316429068491 0.0796729107302616 no 305 0.074487098090209 440 722377 SGTC_2082 5219693 150 µM 1.4419635083295 0.0798475219133258 no 306 0.0746563341960398 467 2834649 SGTC_1607 st000305 50.6 µM 1.44015440190713 0.0801111385169086 no 307 0.0749118602739474 467 5457690 SGTC_1945 st075991 56.6 µM 1.43984346866279 0.080156512792849 no 308 0.0749558449475062 425 1084980 SGTC_1010 4112-3296 15.2 µM 1.43910008212552 0.0802650734213531 no 309 0.0750610843883949 487 704384 SGTC_824 1304-0008 100 µM 1.43667289384754 0.0806203021571275 no 310 0.0754054802415884 499 768245 SGTC_1950 st077106 7.18 µM 1.43264900338587 0.0812118287729953 no 311 0.0759790850385524 469 13831864 SGTC_668 1682-0499 62.6 µM 1.43205724328897 0.0812990951636991 no 312 0.07606371979866 532 682214 SGTC_1159 4092-0538 61.2 µM 1.43052786367414 0.0815249592081351 no 313 0.0762827872838324 507 717301 SGTC_1036 k216-0215 33.5 µM 1.42817464281804 0.0818734146835196 no 314 0.076620798625687 528 622330 SGTC_3034 9090421 49.47 µM 1.42771914540716 0.0819409923764157 no 315 0.0766863566319228 411 17173761 SGTC_3231 9132313 49.47 µM 1.42742630065907 0.0819844610781506 no 316 0.0767285271827329 459 4905967 SGTC_862 0452-0056 10.2 µM 1.42323263708032 0.082608859111333 no 317 0.077334363695432 437 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2900 5328528 85.29 µM 1.42211046534674 0.0827765456745277 no 318 0.0774970925722961 522 795359 SGTC_1337 1486-1011 40.3 µM 1.42152235383921 0.0828645296341793 no 319 0.0775824798484735 446 X1337 SGTC_432 NS 1619 61.3 µM 1.42093942995811 0.0829518069146082 no 320 0.0776671844113183 424 4552 A K+/calcium channel activator. SGTC_1400 3771-8998 51.5 µM 1.41823847896767 0.0833571048255991 no 321 0.0780605756300504 424 670767 SGTC_2726 cimetidine 79.27 µM 1.4179989802564 0.0833931151233571 no 322 0.0780955312459457 386 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_967 1306-0166 352 µM 1.41738897373154 0.0834848866666092 no 323 0.0781846173202925 481 4437607 SGTC_1920 st075728 45.7 µM 1.41600549810328 0.0836933028784774 no 324 0.0783869473553472 462 3400306 SGTC_2212 7123476 200 µM 1.41510849813286 0.0838286418015804 no 325 0.0785183434680705 363 1085715 SGTC_1917 st066507 28.5 µM 1.41506718996105 0.0838348783155192 no 326 0.0785243984718955 521 3156428 SGTC_730 1436-0052 41.2 µM 1.41382520389017 0.0840225503308276 no 327 0.0787066157036634 411 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1295 1013-0063 9.78 µM 1.41299905122255 0.0841475618537777 no 328 0.0788280015346151 483 6826038 SGTC_2682 pyrogallin 40.03 µM 1.41259054665868 0.0842094273891856 no 329 0.0788880751052469 518 822798 An ATP competetive kinase inhibitor. SGTC_3307 9126885 69.2785 µM 1.41227439436881 0.0842573301635508 no 330 0.0789345914037454 514 24824909 SGTC_1338 1486-1223 76 µM 1.41101090143705 0.0844489763342745 no 331 0.0791206998192155 500 3444526 SGTC_3036 9090181 49.47 µM 1.41097439618564 0.0844545182952492 no 332 0.079126081859104 434 25236586 SGTC_819 1013-0258 27.7 µM 1.41049982423076 0.0845265891805555 no 333 0.0791960741516267 484 5753198 SGTC_3293 9120939 62.045 µM 1.40966967238699 0.0846527711447672 no 334 0.0793186218862935 453 934087 SGTC_2902 5787006 60.46 µM 1.40764070341962 0.0849617662349614 no 335 0.0796187441572847 456 591003 SGTC_126 0417-1624 672.48 µM 1.40682628629898 0.0850860326991406 no 336 0.0797394529661999 592 41912 YDL195W SEC31 SGTC_1054 3429-0080 167 µM 1.40644985503513 0.0851435158382413 no 337 0.0797952924718861 501 1162877 SGTC_1203 3992-3522 103 µM 1.40412806028832 0.0854987102177364 no 338 0.0801403595825732 520 5322312 SGTC_1805 st050013 60.3 µM 1.40305525568462 0.0856632050843196 no 339 0.0803001812100975 426 4037144 SGTC_2838 9002687 71.43 µM 1.40222141009533 0.085791223547849 no 340 0.0804245700654212 430 6457060 SGTC_333 3486-0131 40.1 µM 1.39862175358626 0.0863455146305444 no 341 0.0809632197307555 476 6744690 SGTC_2155 5570423 76 µM 1.3976144603096 0.086501100639311 no 342 0.0811144368190188 465 797402 SGTC_946 3434-1334 87.4 µM 1.39557755814602 0.0868163597912508 no 343 0.0814208721710873 478 4047976 SGTC_17 0960-0276 49.807 µM 1.39510662468565 0.0868893700056226 no 344 0.0814918443894968 518 6821114 SGTC_1436 4092-1007 8.32 µM 1.39492585384408 0.0869174076268285 no 345 0.0815190999205403 453 2881121 SGTC_1884 5633444 25 µM 1.3932880980096 0.0871717322029996 no 346 0.0817663441502081 522 5724239 SGTC_120 rhodamine 6G 52.259 µM 1.39139131529062 0.0874669746625258 no 347 0.0820533983657466 584 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2506 ethyl hematommate 54.16 µM 1.39083345222596 0.0875539503371217 no 348 0.0821379682457796 404 3940691 An allergen. SGTC_2008 4012253 172 µM 1.38964894683109 0.087738838944688 no 349 0.0823177523667245 507 603940 SGTC_1376 2910-0861 41.3 µM 1.38898200815568 0.0878430690142355 no 350 0.082419110572748 520 1112859 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.38761413042179 0.0880571316828686 no 351 0.0826272881584558 500 5393153 SGTC_906 1165-0455 526 µM 1.38746733710894 0.0880801268305959 no 352 0.0826496521553883 467 3252859 SGTC_1871 st057448 67.3 µM 1.38656745594637 0.088221190917135 no 353 0.0827868488443193 504 691747 SGTC_2238 6671620 73.2395 µM 1.38355518575195 0.088694615396994 no 354 0.0832473492209832 474 729941 SGTC_1977 st070720 65.3 µM 1.38296227884106 0.0887880222678135 no 355 0.0833382161871525 447 682188 SGTC_540 1187-0821 17.3 µM 1.38010364912667 0.0892394004550378 no 356 0.0837773669506962 469 847520 SGTC_613 3914-0030 117 µM 1.37949632963807 0.0893355158374946 no 357 0.0838708885546832 224 1145395 SGTC_2268 7933382 153.85 µM 1.37921775716619 0.0893796289310814 no 358 0.0839138123692852 568 935025 YOR257W CDC31 SGTC_361 000s-0510 1.45 µM 1.37710511835391 0.0897147014840446 no 359 0.0842398752429604 501 660 SGTC_970 1315-0089 19.5 µM 1.37562075706944 0.0899506848055165 no 360 0.0844695384521703 475 6811083 YLR033W RSC58 SGTC_1567 st069303 68.4 µM 1.37472337234453 0.0900935743232892 no 361 0.0846086111864985 527 5581319 SGTC_3094 9117742 49.47 µM 1.37420586495858 0.0901760530478796 no 362 0.084688890243714 526 17149698 SGTC_2803 7707263 71.43 µM 1.37179237233781 0.0905614489012547 no 363 0.0850640412353636 462 2199229 SGTC_3035 9091303 49.47 µM 1.37136659418036 0.0906295655006704 no 364 0.0851303528316038 445 25237002 SGTC_2716 st080858 38.6235 µM 1.37115044407161 0.0906641600545899 no 365 0.0851640313305274 472 5296050 SGTC_3257 9139206 32.98 µM 1.36602302717898 0.091487672974712 no 366 0.0859658679560768 414 4910041 SGTC_169 k015-0017 16.025 µM 1.36337222671523 0.0919155850615021 no 367 0.0863826147580834 458 1840002 SGTC_2264 7948757 110.76 µM 1.36307313122017 0.0919639602051532 no 368 0.0864297318743482 480 2971411 SGTC_674 0498-0004 451 µM 1.36170594739106 0.0921853260301598 no 369 0.086645351790244 501 4231473 SGTC_1613 st002381 52.1 µM 1.35779547284161 0.0928206627672575 no 370 0.0872642959292137 489 551167 SGTC_644 1498-1197 63.3 µM 1.35369135957303 0.0934909362070667 no 371 0.0879174329471707 549 6741615 SGTC_3259 9138485 49.47 µM 1.35169627751845 0.0938180563251315 no 372 0.0882362481966068 552 17646153 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.34950697940163 0.0941779921288851 no 373 0.0885870900384291 488 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2400 5203494 178.7 µM 1.34913073480179 0.0942399517918838 no 374 0.0886474888993564 477 6777674 SGTC_3200 9114385 49.47 µM 1.34814090376092 0.0944030999780303 no 375 0.0888065337872989 477 17018030 YLR208W SEC13 SGTC_2664 lyso-paf C-16 73.48 µM 1.34550905355858 0.0948379057274088 no 376 0.0892304497849914 523 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1456 k015-0012 13 µM 1.34061795917723 0.0956498755542761 no 377 0.0900222616617509 600 2989616 SGTC_2779 methotrexate 400 µM 1.33697830152245 0.0962574057829807 no 378 0.0906148598587253 530 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1919 st067113 52.3 µM 1.33229035141261 0.0970440896326032 no 379 0.0913823982340198 541 1268243 SGTC_3245 9134821 49.47 µM 1.33199884795182 0.0970931621545882 no 380 0.0914302835417966 544 17014901 SGTC_1668 st014914 51.6 µM 1.33056036100658 0.0973355878472924 no 381 0.0916668563336239 485 2839556 SGTC_1757 st041620 31.8375 µM 1.33018117090869 0.0973995659876108 no 382 0.0917292932020357 531 5289815 SGTC_2360 9040895 200 µM 1.32852209360573 0.097679853472853 no 383 0.0920028448811996 487 4914414 SGTC_3049 9092223 49.47 µM 1.32698673593099 0.0979397660106267 no 384 0.0922565351971223 504 8623917 SGTC_264 promethazine 12.5 mM 1.32687286872078 0.0979590621545921 no 385 0.0922753703143269 644 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3113 9123498 49.47 µM 1.32580238585713 0.0981406043525464 no 386 0.0924525812681406 507 8897275 SGTC_2113 5491891 107.031 µM 1.32436757281079 0.0983843193903269 no 387 0.0926904993138969 542 789979 SGTC_1314 1222-0010 41.1 µM 1.32314391457334 0.098592517934776 no 388 0.0928937615777903 510 3526027 SGTC_2282 7944268 200 µM 1.32125985401884 0.0989137105096265 no 389 0.0932073675279805 568 2970414 SGTC_1170 0310-0127 64.8 µM 1.31525943695295 0.0999417556942015 no 390 0.0942113627928517 545 774975 SGTC_3089 9117425 49.47 µM 1.31182142507383 0.100534291716355 no 391 0.0947901970811178 506 9401657 SGTC_1784 st039334 36.3 µM 1.31031505340345 0.100794718490325 no 392 0.095044638528881 538 3496984 SGTC_412 gemfibrozil 100 µM 1.30951752733308 0.100932796581953 no 393 0.0951795522762834 461 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2035 5154463 94.595 µM 1.30166008158441 0.102300557575549 no 394 0.0965163056268644 574 2769623 SGTC_2364 9055074 200 µM 1.29975332871345 0.102634492972938 no 395 0.0968427630746713 505 6470630 SGTC_302 1094-0063 18.9 µM 1.2995944636741 0.102662351203647 no 396 0.0968699990952172 478 5440289 SGTC_1787 fluconazole 80 µM 1.29919057643162 0.1027332007468 no 397 0.0969392673520664 604 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2436 5633522 8.09 µM 1.2968088534666 0.103151723188986 no 398 0.097348481839724 571 5724242 SGTC_1614 st002383 48.6 µM 1.29538912589329 0.103401789627218 no 399 0.0975930136761513 553 1947235 SGTC_140 0062-0056 502.533 µM 1.29285026028705 0.103850074159642 no 400 0.0980314266840644 577 3758964 SGTC_353 1988-1175 58.3 µM 1.29096541761553 0.104183789181407 no 401 0.0983578347278289 517 2788357 SGTC_1627 st003713 25.6 µM 1.28814790035048 0.104684084487028 no 402 0.0988472419320427 637 16195070 YER133W GLC7 SGTC_529 4076-0302 30.3 µM 1.28788180908363 0.104731423023431 no 403 0.0988935543297419 559 5816522 SGTC_589 1227-0070 34.1 µM 1.28720136665519 0.104852546538011 no 404 0.0990120555224883 556 2841384 SGTC_615 k087-0205 167 µM 1.28132664554362 0.105902507933906 no 405 0.100039478774195 533 9642773 SGTC_1781 st038725 66.3 µM 1.28127589693464 0.105911610979282 no 406 0.100048387927427 645 4270275 YIL048W NEO1 SGTC_670 4204-0025 119 µM 1.27918878315652 0.106286477572565 no 407 0.100415292422824 587 719039 SGTC_2884 9058502 51.95 µM 1.27906392505589 0.106308933680751 no 408 0.100437272956964 575 6471554 SGTC_1590 st077108 57.8 µM 1.27588371231088 0.106882060140275 no 409 0.10099831476612 539 5489485 SGTC_143 4032-1194 15.74 µM 1.2758679948917 0.106884898201891 no 410 0.101001093239044 657 1806963 SGTC_3174 9107204 49.47 µM 1.27521596073676 0.107002682566488 no 411 0.101116406767696 555 3938802 SGTC_2183 6420625 130.508 µM 1.27326319430712 0.107355993033473 no 412 0.1014623313024 647 2897619 SGTC_62 0180-0423 3.232 µM 1.27308034581095 0.107389118486295 no 413 0.101494766241524 542 30102 YGL099W LSG1 SGTC_768 0384-0033 77.3 µM 1.2673691493163 0.108427489760404 no 414 0.102511662791703 628 3965305 YMR134W ERG29 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.25883551837495 0.109992447241205 no 415 0.104044874143896 599 94937 An inhibitor of serotonin biosynthesis. SGTC_245 methotrexate 289.6 µM 1.25812279043807 0.110123881909207 no 416 0.104173676146345 618 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1155 4088-0394 48.2 µM 1.25759506217663 0.110221273223524 no 417 0.104269120026191 576 2326248 SGTC_3039 9090270 49.47 µM 1.25641134428736 0.110439950911319 no 418 0.104483435368384 536 17173750 SGTC_3301 9125354 19.7965 µM 1.25609673212787 0.110498124023291 no 419 0.104540450403411 516 41905162 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.2549019643925 0.110719241707104 no 420 0.104757175405001 596 3256 An antibiotic and ribosome inhibitor. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.2537067064911 0.110940767202822 no 421 0.104974314703493 566 2724278 An inhibitor of dopamine biosynthesis. SGTC_557 1315-0110 16.2 µM 1.2530616457297 0.111060452643429 no 422 0.105091636440099 584 6833801 SGTC_692 k241-0027 77.8 µM 1.25223335821352 0.111214269784905 no 423 0.105242422036563 564 3600480 SGTC_3205 9113483 49.47 µM 1.25037129597859 0.111560620802314 no 424 0.105581972532662 626 17018033 SGTC_1030 k029-0042 36.7 µM 1.24976617204311 0.111673342260309 no 425 0.105692488371058 635 6080581 SGTC_1721 st082152 9.2685 µM 1.2460131780784 0.11237426353165 no 426 0.10637977860194 547 5296051 SGTC_663 1486-0733 13.9 µM 1.24276418448876 0.112983589868924 no 427 0.106977372053364 659 722445 YPR165W RHO1 SGTC_2854 9024559 71.43 µM 1.24152272186991 0.113217039177623 no 428 0.107206354836371 565 3163529 SGTC_3167 9103034 49.47 µM 1.23732113354118 0.114009674299655 no 429 0.107983942516858 511 5127859 SGTC_192 3455-0609 60.9 µM 1.23719343457155 0.114033826626605 no 430 0.108007639182974 575 3769639 SGTC_1078 idebenone 36.1 µM 1.23553520276835 0.114347787094259 no 431 0.108315691706069 645 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3227 9130768 49.47 µM 1.23459249935373 0.114526547519279 no 432 0.108491100961957 590 17720899 SGTC_2449 5812982 45.77 µM 1.23207990337261 0.115003970651338 no 433 0.108959618841419 544 776185 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.2305739446699 0.115290798221973 no 434 0.109241127584165 584 6312947 SGTC_2920 7982904 15.77 µM 1.22847587257235 0.115691247896369 no 435 0.10963419060739 528 6456808 SGTC_1140 3229-1848 2.98 µM 1.22735486838423 0.115905613478139 no 436 0.109844620716336 606 2849525 SGTC_230 MPP+ 141.667 µM 1.22672787943504 0.116025633219134 no 437 0.109962442729652 572 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2868 9035608 32.47 µM 1.22655562534749 0.116058621956109 no 438 0.109994828110514 599 6462614 SGTC_2099 5377090 177.372 µM 1.22577102577154 0.116208966473376 no 439 0.110142426754132 600 2243829 SGTC_3219 9131112 49.47 µM 1.22563347681027 0.116235337758165 no 440 0.110168317054579 579 17612988 YMR079W SEC14 SGTC_2643 anethole 100 µM 1.2220991261925 0.116914410628484 no 441 0.110835071762894 628 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_90 0870-0863 4.608 µM 1.22204628367647 0.116924584821113 no 442 0.110845062383498 642 1738164 SGTC_1482 3346-2049 8.48 µM 1.21940872596941 0.117433212471835 no 443 0.11134454981987 580 3826804 SGTC_902 1120-0002 2.07 µM 1.21506461789079 0.118274343457009 no 444 0.112170723509208 630 3280475 SGTC_2318 6029776 164 µM 1.21454864672617 0.118374531042766 no 445 0.112269142597948 620 818325 SGTC_2315 7733312 200 µM 1.21077915741968 0.119108283793361 no 446 0.112990027641646 560 726316 SGTC_2416 tofa 880 nM 1.2105036123672 0.119162045880985 no 447 0.113042852735063 574 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1776 st049249 45.9 µM 1.21049965198329 0.119162818723421 no 448 0.113043612113775 630 1822314 SGTC_2691 st077356 60.2 µM 1.2063902619424 0.119966646154675 no 449 0.113833524528305 641 2839272 SGTC_1234 0326-0494 15.5 µM 1.20548054164096 0.120145109772261 no 450 0.114008922686105 607 1547813 SGTC_991 3996-0057 64.7 µM 1.20411151374714 0.120414030136131 no 451 0.11427324016925 617 715343 SGTC_188 3229-0966 278.469 µM 1.19949322665586 0.121324334055912 no 452 0.115168108462457 722 5722370 SGTC_2215 7188065 200 µM 1.19934720447448 0.121353194985053 no 453 0.115196483663978 558 940217 SGTC_2361 9034121 116 µM 1.1990799062421 0.121406038336379 no 454 0.115248438245397 605 6496917 SGTC_3007 9078383 71.4286 µM 1.19776504377918 0.121666214741102 no 455 0.115504249690906 630 6496995 SGTC_2005 4024620 188 µM 1.19346187220987 0.122520436846487 no 456 0.116344267952646 620 236743 SGTC_1610 st001799 48.1 µM 1.19282953961716 0.122646314874033 no 457 0.116468069349842 557 621897 SGTC_2116 5511452 16.8835 µM 1.19129655586064 0.122951861426489 no 458 0.116768592754321 636 870744 SGTC_3111 9122088 49.47 µM 1.19025517021531 0.123159729309722 no 459 0.116973057458382 497 16876704 SGTC_2937 9044753 11.33 µM 1.18989492515001 0.123231694058458 no 460 0.117043846676051 660 6465530 YGL099W LSG1 SGTC_2375 9072683 200 µM 1.18808872395697 0.123592956047396 no 461 0.117399228180885 698 16798029 SGTC_3119 9125183 49.47 µM 1.18584709081211 0.124042340223903 no 462 0.117841345426091 485 22695334 SGTC_2936 9038235 15.59 µM 1.1846638091544 0.124280015307167 no 463 0.118075198533672 614 4749415 SGTC_2213 7173844 200 µM 1.18350345960486 0.124513393372741 no 464 0.118304838113883 666 892728 SGTC_401 neomycin 50 µM 1.18336025460011 0.124542217046635 no 465 0.11833320104897 601 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1879 gemcitabine 100 µM 1.18279822259984 0.124655385454784 no 466 0.118444562588123 647 60750 A nucleoside analog which inhibits DNA replication. SGTC_2095 5432005 200 µM 1.17989972379977 0.12524015612922 no 467 0.119020049872974 592 783734 SGTC_2106 5357045 167.29 µM 1.17748428033035 0.125728931656433 no 468 0.119501134081281 647 668842 SGTC_1301 naphtanilide LB 4.81 µM 1.17598764109917 0.126032449999322 no 469 0.119799907384593 674 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1135 dihydrocapsaicin 536.708 nM 1.17491320475085 0.126250660399414 no 470 0.120014721078541 627 107982 A Capsaicinoid. SGTC_3155 9099265 49.47 µM 1.1714093896166 0.126964089252318 no 471 0.120717129925 596 25236499 SGTC_2949 9072542 2.23 µM 1.17099231880175 0.127049197589564 no 472 0.120800932335853 654 16457352 SGTC_3216 9129716 49.47 µM 1.16825686066385 0.127608385025504 no 473 0.121351585393393 592 8056934 SGTC_1116 jasmonic acid  1.58368 µM 1.16778383750341 0.127705254557428 no 474 0.121446984580215 655 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1841 st054148 70 µM 1.16636458690602 0.127996206951991 no 475 0.121733535041777 595 675442 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.1651576851839 0.128243988991644 no 476 0.121977585199828 680 23665772 A membrane-active detergent. SGTC_697 0508-1955 564 µM 1.16466691941538 0.128344840483878 no 477 0.122076922198691 706 6243113 SGTC_1319 1306-0155 43.7 µM 1.16404917079886 0.128471864986279 no 478 0.122202042820836 711 3122360 SGTC_2444 5485484 36.41 µM 1.16348454061766 0.128588043323638 no 479 0.122316483407502 674 6790631 SGTC_3082 9117008 49.47 µM 1.16021963287046 0.129261260561075 no 480 0.122979697778464 655 41448529 SGTC_1921 5740136 50 µM 1.15777775621825 0.129766364689742 no 481 0.123477371511381 714 1774243 SGTC_2705 st078069 42.8 µM 1.15755773730805 0.129811942808831 no 482 0.123522282282605 598 1530061 SGTC_999 SEC7.066 22.7 µM 1.1559645493505 0.13014231114227 no 483 0.123847828885228 700 740511 YDR170C SEC7 SGTC_372 0155-0182 15.9 µM 1.1539535363439 0.130560151061111 no 484 0.124259609280153 717 771486 SGTC_1974 st069448 26.9 µM 1.15394799536201 0.13056130362333 no 485 0.12426074518778 633 6323587 YNR016C ACC1 SGTC_2234 tolnaftate 200 µM 1.15297238474266 0.130764347004231 no 486 0.12446085971247 592 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_497 capsazepine 133 µM 1.15292835577815 0.130773515425238 no 487 0.124469896121735 641 2733484 A calcium channel blocker. SGTC_864 0469-0573 172 µM 1.15153921418487 0.131063013074067 no 488 0.124755236113286 639 689425 SGTC_1502 4534-4282 27.7 µM 1.15021179627189 0.131340060873343 no 489 0.125028324414828 631 3278949 SGTC_604 1000-0114 314 µM 1.14716005311694 0.131978528422467 no 490 0.125657738993098 717 1572745 SGTC_2403 6032726 181.2 µM 1.14671653166808 0.132071497197261 no 491 0.12574939787763 646 2881040 SGTC_1016 4226-1401 38 µM 1.14552818873404 0.132320814331529 no 492 0.125995212670103 679 2901613 SGTC_2232 chlorophetanol 41.5365 µM 1.1453967995433 0.132348399994981 no 493 0.126022411749981 796 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2759 disulfiram 3.38 µM 1.14502435570777 0.132426617545174 no 494 0.126099534174217 627 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2597 laccaic acid a 100 µM 1.14258714368843 0.132939246759475 no 495 0.126605022931059 687 5491415 A textile dye. SGTC_2685 mycophenolic acid 18.85 µM 1.14169675282312 0.133126866759847 no 496 0.126790045516795 630 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2737 bleomycin 30.5 nM 1.1382655529477 0.133851580838817 no 497 0.127504806641943 728 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1223 0764-0573 147 µM 1.1322734071526 0.135123692754744 no 498 0.128759753315251 704 1609797 SGTC_348 k064-0012 10.7 µM 1.12951605632113 0.135711845112375 no 499 0.129340100060831 627 5066323 SGTC_849 0386-0493 241 µM 1.12840738691103 0.135948821631579 no 500 0.129573954774795 650 726119 SGTC_935 2996-0153 430 µM 1.12727254117329 0.136191686569229 no 501 0.129813634126608 685 23738523 SGTC_2859 9028643 45.46 µM 1.12531107835335 0.136612153083876 no 502 0.130228618431523 640 17151580 SGTC_3270 9137563 49.47 µM 1.1242480231 0.136840404122284 no 503 0.130453910877038 622 17015724 SGTC_249 wiskostatin 11.211 µM 1.12215084157824 0.137291458808354 no 504 0.13089915495521 712 2775510 A n-wasp and actin depolymerizer. SGTC_1056 3448-1962 115 µM 1.11882856766674 0.13800807857075 no 505 0.131606640880534 659 715507 SGTC_762 1165-0429 115 µM 1.11670425125169 0.138467631878101 no 506 0.132060399773042 682 5967793 SGTC_2085 5307070 144.047 µM 1.11650850660313 0.138510029723407 no 507 0.132102265501715 629 2840351 SGTC_1617 st002906 78 µM 1.11587898666435 0.138646442275622 no 508 0.1322369688254 714 5150859 SGTC_2239 6685329 187.64 µM 1.11209466069129 0.139468407650332 no 509 0.133048726090186 686 805680 SGTC_2662 daunorubicin 22.37 µM 1.1117537483075 0.139542617111398 no 510 0.133122021593077 655 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2659 sanguinarine 24.21 µM 1.11117251209762 0.139669201931853 no 511 0.133247050323826 683 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_850 0388-0143 75.9 µM 1.10807562396423 0.140344975320013 no 512 0.133914578653878 666 67273 SGTC_1789 tunicamycin 25 nM 1.10728764991751 0.14051727325732 no 513 0.134084791096939 699 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_312 4092-0653 6.84 µM 1.10712306428768 0.140553279574737 no 514 0.134120362449 794 1148278 SGTC_746 1095-0025 46.6 µM 1.10583185526387 0.140835974033773 no 515 0.134399652146127 755 6749286 SGTC_2696 st077691 74.316 µM 1.10446325279231 0.141136033706605 no 516 0.134696117787316 618 757133 SGTC_2764 methyldopa 94.69 µM 1.10393694912573 0.141251538636555 no 517 0.13481024467701 730 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1691 st019933 84.6 µM 1.10389249751153 0.141261297118345 no 518 0.134819886873024 685 6176082 SGTC_747 3448-8087 38.7 µM 1.10145754328228 0.14179654191877 no 519 0.135348786492253 723 5168703 SGTC_834 0312-0008 75.7 µM 1.098558842007 0.14243551490258 no 520 0.135980269231161 727 6385573 YIL048W NEO1 SGTC_2650 prasterone 100 µM 1.09616169371119 0.142965397598364 no 521 0.136504009995165 622 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.09498697314976 0.143225551904232 no 522 0.136761171804868 637 77254 SGTC_731 3966-0296 387 µM 1.0939880174089 0.143447032640983 no 523 0.136980116794767 701 660956 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.09377961019217 0.143493268212882 no 524 0.137025824391137 771 16486 A toxic proline analog. SGTC_400 oxethazaine 37.5 µM 1.09361779844124 0.143529173421491 no 525 0.137061319917383 676 4621 A local anesthetic. SGTC_2908 7930301 100 µM 1.09131909418144 0.144039899302987 no 526 0.137566249376281 799 2223178 SGTC_2995 9067767 71.4286 µM 1.09114163781225 0.144079377436244 no 527 0.137605281866526 639 11673567 SGTC_1750 st081859 2.357 µM 1.09099501338353 0.144112001993774 no 528 0.137637538407132 872 5291695 SGTC_908 3448-7491 47.7 µM 1.09053205655121 0.144215044544874 no 529 0.137739420148152 778 1203031 SGTC_549 1661-1316 519 µM 1.08975910870558 0.144387193969653 no 530 0.137909635489977 744 2857282 SGTC_486 niguldipine 82 µM 1.08948323816987 0.144448668834158 no 531 0.137970421277191 652 1236 A calcium channel blocker. SGTC_16 erodoxin 22.806 µM 1.08935885990111 0.144476390998661 no 532 0.137997832974531 763 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2596 sinensetin 100 µM 1.08909078537795 0.14453615322412 no 533 0.138056926485658 672 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2252 omeprazole 400 µM 1.08891165478622 0.144576096337252 no 534 0.138096423091532 621 4594 A proton pump inhibitor. SGTC_577 r071-0003 38.6 µM 1.08581982829022 0.145266693640188 no 535 0.138779356055788 853 4568517 YMR134W ERG29 SGTC_1680 diphenhydramine 100 µM 1.08471650207457 0.145513671513382 no 536 0.139023618370773 695 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1445 4239-0156 97.7 µM 1.08296284630458 0.145906805454459 no 537 0.139412457290167 808 4008346 SGTC_2752 diclazuril 33.15 µM 1.08221563738888 0.146074531140832 no 538 0.139578360833715 893 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3202 9113761 49.47 µM 1.08212876144645 0.146094040550775 no 539 0.139597658695166 778 4798415 SGTC_578 3460-0051 92 µM 1.07864944929607 0.146876815739531 no 540 0.140372014246642 825 2876744 SGTC_1129 3453-1384 223 µM 1.078641124063 0.146878692116886 no 541 0.140373870601241 761 1084452 SGTC_1306 1185-0270 9.02 µM 1.07609071871018 0.147454270609699 no 542 0.140943343066919 776 1548076 SGTC_331 k048-0133 24.5 µM 1.07439410231406 0.147838000972571 no 543 0.141323042341327 672 6813582 SGTC_1175 0741-0056 27.6 µM 1.07410779909629 0.147902821164475 no 544 0.141387184725565 802 765927 SGTC_271 rotenone 740 µM 1.07400406888513 0.147926310793331 no 545 0.141410428952499 755 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.07244069707226 0.148280637625707 no 546 0.141761068416275 804 688788 SGTC_645 0845-0943 5.41 µM 1.06942298195598 0.148966185263203 no 547 0.142439558090137 707 1885106 SGTC_953 1188-0045 9.7 µM 1.06826188800488 0.149230519311132 no 548 0.142701197511204 747 6144426 SGTC_1705 st027868 56.3335 µM 1.0652485358011 0.149917997966936 no 549 0.143381737514114 718 292948 SGTC_98 0074-0023 107.663 µM 1.06480434620041 0.150019515552523 no 550 0.143482238979438 774 3563821 SGTC_1390 3413-2614 145 µM 1.06338955535926 0.150343165221435 no 551 0.143802663678752 750 3421432 SGTC_1463 k081-0032 34.1 µM 1.06265225436371 0.150512015576391 no 552 0.143969840316233 611 977755 SGTC_2669 eugenol 100 µM 1.06081080510064 0.1509342800377 no 553 0.144387945379183 691 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_780 0109-0199 192 µM 1.06058401758871 0.15098633937662 no 554 0.144439494516537 786 610414 SGTC_1865 st057639 52.2 µM 1.05948740415472 0.151238236853131 no 555 0.144688931330459 740 688818 SGTC_797 k781-0471 270 µM 1.05905638787739 0.151337319889476 no 556 0.144787050116656 771 23738129 SGTC_2661 dactinomycin 12.96 µM 1.05657669218605 0.151908196675365 no 557 0.14535241125373 789 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2888 9058547 12.99 µM 1.05478562421434 0.152321425958967 no 558 0.145761690420018 647 16476514 SGTC_1233 0325-0408 14.2 µM 1.05426691229525 0.152441240671843 no 559 0.145880366445169 744 12874 SGTC_3004 9076122 71.4286 µM 1.05328598155005 0.15266799197219 no 560 0.146104970912466 759 44782551 SGTC_2176 5809774 33.9695 µM 1.05006147836433 0.15341494183689 no 561 0.146844924054048 790 2870539 SGTC_2557 derrustone 83.84 µM 1.0480903777493 0.153872733659794 no 562 0.147298484562087 761 629853 An antioxidant. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.04749854512615 0.154010364198874 no 563 0.147434851416804 831 368090 SGTC_2583 asiatic acid 100 µM 1.04427238338462 0.154762039117946 no 564 0.148179693107158 734 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1867 st057372 64 µM 1.04404792689211 0.154814426067859 no 565 0.148231608126757 739 688837 SGTC_1005 4092-0690 4.4 µM 1.04152153032401 0.155404881483423 no 566 0.148816783028576 703 1529343 SGTC_1397 3532-0190 20.1 µM 1.03946812363838 0.155885885615221 no 567 0.149293537788992 693 5322280 SGTC_2433 5607874 27.82 µM 1.03726278221644 0.156403571920624 no 568 0.149806702922731 744 2252428 SGTC_2443 5493264 126.67 µM 1.03724873478196 0.156406873068587 no 569 0.149809975413808 763 5340055 SGTC_2570 licareol 100 µM 1.0363422697969 0.156619989411095 no 570 0.150021246360131 735 443158 SGTC_216 k038-0035 28.382 µM 1.03589621969358 0.156724929095572 no 571 0.150125280717899 726 4444231 YPR107C YTH1 SGTC_2070 5230947 200 µM 1.0334870711188 0.15729251563473 no 572 0.150688008928151 808 2835538 SGTC_580 1123-0028 41 µM 1.033212387458 0.157357315811326 no 573 0.150752258544123 849 1677248 YPR107C YTH1 SGTC_318 1488-0629 67.2 µM 1.02965156699793 0.158198931221199 no 574 0.151586799485037 740 3662576 SGTC_556 4058-0063 51.5 µM 1.02267628381092 0.15985611521253 no 575 0.153230464149654 832 6615692 SGTC_2469 5655019 90.81 µM 1.02150273295931 0.160136038742833 no 576 0.153508157468579 838 2788239 SGTC_66 0109-0187 42.4 µM 1.02048714375013 0.160378542667429 no 577 0.15374874172368 715 759417 SGTC_1861 st057647 17.4 µM 1.01610895226067 0.161426719546579 no 578 0.154788753229286 793 688668 SGTC_1971 st069429 63.5 µM 1.01439518464124 0.161838224149249 no 579 0.155197110559866 770 1246522 YGL099W LSG1 SGTC_2473 5854593 8.94 µM 1.01425454724906 0.161872023886938 no 580 0.155230653247695 764 2872951 SGTC_2787 5284540 71.43 µM 1.01405878138339 0.161919080445383 no 581 0.155277352305044 784 736958 SGTC_125 0133-0007 11.75 µM 1.01152806984091 0.162528193825366 no 582 0.155881876682843 872 26541 SGTC_831 k061-1017 217 µM 1.01032934658531 0.162817232530175 no 583 0.156168762807055 926 1240153 SGTC_2030 5175110 200 µM 1.00967340998344 0.162975534776472 no 584 0.156325892921396 786 2831986 SGTC_301 4119-0100 24.5 µM 1.00787131006174 0.163410964365923 no 585 0.156758123208875 814 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1673 st016611 27.3 µM 1.00616556763775 0.163823807203837 no 586 0.157167966198674 821 5226799 SGTC_656 4090-1979 187 µM 1.00604438922207 0.163853161888685 no 587 0.157197108822019 847 22330961 SGTC_1263 0774-1208 64.8 µM 1.00494855695013 0.164118775145095 no 588 0.157460810724499 868 906585 SGTC_978 1416-0512 87.4 µM 1.002229458066 0.16477904933821 no 589 0.158116391703163 825 6814003 SGTC_2026 5148700 152 µM 1.0005721144819 0.165182342158588 no 590 0.158516858576083 796 79838 SGTC_3085 9117376 49.47 µM 0.999321789760792 0.165487014708939 no 591 0.158819416603942 787 16480349 SGTC_1926 methyl fluorone black 53.6 µM 0.998400786014068 0.16571167240813 no 592 0.159042526316456 719 72721 Reacts with homocysteine. SGTC_234 nsc-17383 10.7 µM 0.997009175448665 0.166051497721592 no 593 0.159380028131315 856 408974 SGTC_2302 7771753 200 µM 0.996119701781995 0.166268939073753 no 594 0.159595994140073 807 2203047 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.995538966356805 0.166411005242713 no 595 0.15973710117427 772 4330530 SGTC_1904 st060225 78 µM 0.994503762054837 0.166664443122218 no 596 0.159988837392988 796 66595 SGTC_3125 9127534 49.47 µM 0.992586553183736 0.167134470104606 no 597 0.160455740225735 693 1639235 SGTC_3240 9133527 49.47 µM 0.990755751389558 0.167584110269481 no 598 0.160902430258968 784 17617455 SGTC_1205 4161-2785 76 µM 0.988358173563614 0.168174126378032 no 599 0.161488632140714 727 3498106 SGTC_3131 9127911 49.47 µM 0.988007604331083 0.168260509262564 no 600 0.16157446200098 773 45595681 SGTC_2257 7960413 200 µM 0.987072522828433 0.168491059918957 no 601 0.161803543417587 862 2974689 YIL048W NEO1 SGTC_272 doxorubicin 8.13 µM 0.986840565568631 0.168548281973729 no 602 0.161860402330443 844 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1486 3970-0793 4.53 µM 0.984189258832937 0.169203226126154 no 603 0.162511233027576 841 2844330 SGTC_1767 st044992 70.3 µM 0.98341429263933 0.169394971834006 no 604 0.162701789368986 789 9600693 SGTC_1717 st033143 58.0435 µM 0.982581550024817 0.169601168225305 no 605 0.162906714278584 837 674616 SGTC_1516 st013856 110 µM 0.981873221365941 0.169776685003849 no 606 0.163081154888761 780 5281404 A mutagen and neurotoxin. SGTC_1114 scopoletin 1.73284 µM 0.97809990308994 0.170713637763184 no 607 0.164012457892495 819 5280460 A coumarin with genotoxic properties. SGTC_1370 2001-0092 44.6 µM 0.977066026470022 0.170970936259441 no 608 0.164268232844254 930 790957 SGTC_3261 9137475 49.47 µM 0.975540928008542 0.17135093665579 no 609 0.164646005084234 633 17027690 SGTC_1174 0739-0097 51.1 µM 0.97481464037818 0.171532091381413 no 610 0.164826106791514 816 728447 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.972343994558927 0.172149249537531 no 611 0.165439721960206 877 6708739 YPR165W RHO1 SGTC_3281 9140613 49.47 µM 0.9716422016962 0.172324812909767 no 612 0.165614289980605 755 16013766 SGTC_1559 coumarin 343 70.1 µM 0.970972422809511 0.172492474024707 no 613 0.165781005712262 785 108770 A hepatotoxic, DNA x-linker. SGTC_2940 9060638 45.86 µM 0.970587354782023 0.1725889125222 no 614 0.165876902710807 809 4027022 SGTC_2507 purpurin 79.67 µM 0.969673185491298 0.172817999633157 no 615 0.166104710186672 826 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_772 k072-0172 35.3 µM 0.965256531770542 0.173927523397811 no 616 0.167208168998553 765 5861980 SGTC_559 1550-0661 158 µM 0.964585234594267 0.17409655811183 no 617 0.167376298955679 847 5830875 SGTC_2978 9011784 42.97 µM 0.963812124833772 0.174291358888301 no 618 0.167570063348199 946 2994934 SGTC_106 0092-0003 11.579 µM 0.963417540583317 0.174390835801793 no 619 0.167669013615511 787 1072148 SGTC_1814 st052110 31.539 µM 0.962969527182473 0.17450382622137 no 620 0.167781407971086 831 674163 SGTC_771 0250-0039 27.3 µM 0.959307446269889 0.175429157508722 no 621 0.168701942627075 810 3005115 SGTC_1455 4262-0120 131 µM 0.959023101514021 0.175501135384502 no 622 0.168773553712493 876 1529587 SGTC_2625 euphol 100 µM 0.958444862729133 0.175647566127598 no 623 0.16891924107127 866 6708538 A triterpene alcohol. SGTC_1086 cerivastatin 2.18 µM 0.957271554170985 0.175944927652077 no 624 0.169215104557508 829 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2619 obliquin 87.91 µM 0.956609682811817 0.176112811867631 no 625 0.169382149853171 904 6708593 A bioactive alkalod. YER133W GLC7 SGTC_122 0236-0016 402.397 µM 0.954833495412352 0.176563844270811 no 626 0.169830952841722 914 6808838 SGTC_1844 rapamycin 4 nM 0.954076534794107 0.176756283277829 no 627 0.170022451443154 920 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3305 9127027 53.8275 µM 0.948390764134909 0.178205989246594 no 628 0.171465279749376 858 41905295 SGTC_652 0437-0092 114 µM 0.94677936187115 0.178618208990817 no 629 0.171875610186834 835 3091274 SGTC_1434 4073-0095 163 µM 0.946306249482352 0.178739351846922 no 630 0.171996203374183 898 24133745 SGTC_1471 k673-0312 37 µM 0.945837441501665 0.178859443547746 no 631 0.17211575266469 870 24099884 SGTC_2947 9072639 7.68 µM 0.940693698201403 0.180180418944942 no 632 0.173430924671273 943 16488146 SGTC_1885 st057546 99.9 µM 0.938959435558985 0.180627175428522 no 633 0.173875785761368 896 702008 SGTC_2381 9035592 200 µM 0.936221166924829 0.181333982780186 no 634 0.174579663558055 799 4749657 SGTC_328 k915-0120 63.5 µM 0.933931178404404 0.181926407032545 no 635 0.175169697343438 863 6624543 SGTC_199 4063-0024 41.6 µM 0.932828219566397 0.18221217590889 no 636 0.175454334242431 900 306215 SGTC_1773 st048542 73.5835 µM 0.931907122476688 0.182451040539997 no 637 0.175692263210016 850 3237138 SGTC_1594 piperine 70.1 µM 0.930885537515964 0.182716192980578 no 638 0.175956388211771 863 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.928093560048145 0.183442077329709 no 639 0.176679519942358 910 4174840 SGTC_733 4069-0007 56.1 µM 0.926913442194411 0.183749435136203 no 640 0.176985738679825 913 5717425 YNL287W SEC21 SGTC_2730 imipramine 71.33 µM 0.926046561745645 0.183975415555159 no 641 0.17721089162822 974 3696 A tricyclic antidepressant. SGTC_2725 haloperidol 53.21 µM 0.926029251530359 0.183979929784054 no 642 0.177215389413748 896 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1609 st001574 46.4 µM 0.926011264124466 0.183984620686561 no 643 0.177220063232925 887 3960012 SGTC_2293 7624732 200 µM 0.925414635716758 0.184140256511916 no 644 0.177375134332518 832 894453 SGTC_93 0109-0045 59.227 µM 0.924935909130518 0.184265195838278 no 645 0.177499623220198 1036 88733 SGTC_1013 4112-3890 241 µM 0.921288830859204 0.185218750880763 no 646 0.17844982542912 853 705171 SGTC_767 0929-0023 86 µM 0.92007249881572 0.185537449939653 no 647 0.178767437298707 951 1204563 SGTC_2335 9018011 154.17 µM 0.918875397154608 0.185851442399424 no 648 0.179080374932905 926 6458208 SGTC_12 0849-0099 9.267 µM 0.918614317508917 0.185919965746649 no 649 0.179148670231296 870 6071388 SGTC_291 SEC14.278 35.5 µM 0.918371178771793 0.185983794383296 no 650 0.179212287135048 917 1068044 SGTC_1718 roemerine 11.9335 µM 0.912890621665139 0.187426149776635 no 651 0.180650035205281 889 235224 An aporphine alkaloid with mutagenic activity. SGTC_1769 st044406 64.4 µM 0.911405480901543 0.187818191841769 no 652 0.181040883407377 897 670903 SGTC_1137 ixabepilone 100 µM 0.908229301504231 0.188658326264214 no 653 0.181878543045152 905 154225 A novel microtubule stabilizer. SGTC_518 1021-0119 62.6 µM 0.908090601425509 0.188695066676905 no 654 0.181915177826999 831 1097762 SGTC_1272 0839-0021 27 µM 0.907912904707255 0.188742143395586 no 655 0.18196211951459 897 5027250 SGTC_2460 5552655 174.22 µM 0.90636340528967 0.189152954864704 no 656 0.182371767752164 865 5401989 SGTC_1009 4106-0057 9.87 µM 0.905309678745562 0.189432638706342 no 657 0.182650675141175 967 2928005 SGTC_2065 5221596 34.26 µM 0.9049752547549 0.189521455886878 no 658 0.182739248369134 862 788581 SGTC_2627 acetyl isogambogic acid 100 µM 0.904625995993022 0.18961424027228 no 659 0.182831779252734 867 6857789 A caspase activator and apoptosis inducer. SGTC_2588 indole-3-carbinol 100 µM 0.902453969114461 0.190191889878148 no 660 0.183407881545577 930 3712 Induces cell cycle arrest. SGTC_803 4488-1585 147 µM 0.901813436899585 0.190362445371617 no 661 0.183577990352168 907 747204 SGTC_2172 5754775 163.918 µM 0.900858435662658 0.190616909384764 no 662 0.183831796520868 825 2263357 SGTC_673 1082-0474 110 µM 0.898533618500692 0.191237238774893 no 663 0.184450565278152 1001 3098046 SGTC_402 epigallocatechin gallate 10 µM 0.897240490975088 0.191582818108721 no 664 0.18479530161139 922 65064 An antioxidant. SGTC_1186 1319-0216 26 µM 0.89624118604054 0.191850137253615 no 665 0.185061981591931 964 4565136 SGTC_492 tmb-8 126 µM 0.896177630190127 0.191867146486143 no 666 0.185078950536249 780 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1011 4112-3381 17.4 µM 0.894980959565336 0.1921875796172 no 667 0.185398633197037 902 2877139 SGTC_2999 9069765 71.4286 µM 0.894557369063582 0.192301083077536 no 668 0.185511874699419 938 2097066 SGTC_1131 3454-3128 32.3 µM 0.892285032194787 0.19291066812734 no 669 0.186120087450974 962 710982 SGTC_1901 st060216 58.6 µM 0.891734189934562 0.193058616542517 no 670 0.186267711580825 943 688792 SGTC_2881 9058953 51.95 µM 0.891387784066379 0.193151691716814 no 671 0.186360584498868 975 17122249 SGTC_3247 9135149 49.47 µM 0.890979876348022 0.193261326826119 no 672 0.186469983102287 870 8934436 YOR116C RPO31 SGTC_2131 toluylene red 5.2905 µM 0.888572863029486 0.193909043107235 no 673 0.187116340367801 894 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1433 4060-0023 7.6 µM 0.884704743003161 0.194952703878122 no 674 0.188157948456046 946 3840627 SGTC_2207 7258803 200 µM 0.883608113655734 0.195249206658814 no 675 0.188453898800725 887 3666799 SGTC_3246 9135460 32.98 µM 0.882663374253358 0.1955048615595 no 676 0.188709088251179 867 41446951 SGTC_879 0831-1030 162 µM 0.882609624039847 0.195519412955775 no 677 0.188723613457559 931 1549252 SGTC_2366 9070441 60.58 µM 0.87984595190856 0.196268487445047 no 678 0.189471383682812 979 6837235 SGTC_1855 st056195 39.6 µM 0.87704434184453 0.197029617982546 no 679 0.190231276966981 910 4028379 SGTC_2519 cryptotanshinone 88.04 µM 0.875295338764647 0.197505684829325 no 680 0.190706614847519 944 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_121 0557-0495 61.343 µM 0.874082231387524 0.197836292589405 no 681 0.191036736636534 1148 3104427 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.874016332571094 0.197854261541944 no 682 0.191054679651025 971 5282309 SGTC_166 k072-0058 166.424 µM 0.872330159809979 0.198314373829779 no 683 0.191514144426773 996 5846229 SGTC_914 3820-6779 408 µM 0.871447224255803 0.198555561154547 no 684 0.191755005119099 955 2893481 SGTC_340 k038-0059 454 µM 0.870548252357136 0.198801310746739 no 685 0.192000430929633 958 23733424 SGTC_2205 7238770 200 µM 0.87030902274652 0.198866739196559 no 686 0.192065774710193 962 279867 SGTC_2533 agelasine 13.65 µM 0.868185655010182 0.199448041428628 no 687 0.192646352974875 971 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3171 9103192 49.47 µM 0.867387249400751 0.199666880711611 no 688 0.192864932858478 999 13018434 SGTC_2870 9038528 12.99 µM 0.866258115341036 0.199976617656639 no 689 0.193174314924073 847 6463316 SGTC_1778 st046819 58.9 µM 0.865698620397683 0.200130201770482 no 690 0.193327728392832 1048 671715 SGTC_2853 9015042 58.44 µM 0.865217139888476 0.200262427280026 no 691 0.193459809812 927 6457456 SGTC_1807 st050092 58.9 µM 0.864794815529529 0.200378450368602 no 692 0.193575708616584 909 5008496 SGTC_370 0180-0345 38.7 µM 0.863952418593932 0.20060999849352 no 693 0.193807014708702 881 3989527 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.863743290633477 0.200667506000267 no 694 0.193864463342538 913 803109 SGTC_8 0354-0001 70 µM 0.861986830003615 0.201150900661804 no 695 0.194347382582818 1028 4993152 SGTC_453 enantio-paf c16 10 µM 0.859941350638056 0.201714715266862 no 696 0.194910686493806 1020 13871343 A lipid and platelet activating factor SGTC_2003 4023581 200 µM 0.85821275262906 0.202191922006948 no 697 0.195387497740517 935 16641307 SGTC_1694 st024011 44.9 µM 0.856836507376359 0.202572338710225 no 698 0.195767623232006 1017 2787533 SGTC_877 0771-0151 33.1 µM 0.856477109946528 0.202671752446498 no 699 0.195866964377881 971 6166523 SGTC_393 acivicin 6.25 µM 0.855369510995215 0.202978311232431 no 700 0.196173308465916 882 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_751 0833-0568 350 µM 0.851202925597291 0.204134007327226 no 701 0.197328318967137 961 6954252 SGTC_3199 9111318 49.47 µM 0.850454002308935 0.20434215281005 no 702 0.197536361695271 937 8548020 SGTC_724 3910-0327 137 µM 0.849867731739565 0.204505180959943 no 703 0.197699313766887 987 2885483 SGTC_629 3448-6466 76.7 µM 0.849231606866851 0.204682159957449 no 704 0.19787621454975 991 573744 SGTC_2862 9027634 71.43 µM 0.848642284800783 0.204846199021968 no 705 0.198040185180245 887 5012562 SGTC_2703 st077852 53.4 µM 0.848458131125025 0.204897474620782 no 706 0.198091440188846 929 6281836 SGTC_2523 spermine 47.74 µM 0.847966428249353 0.205034421353781 no 707 0.198228333798339 971 1103 A DNA binding polyamine. SGTC_128 0906-2981 13.371 µM 0.846797017561879 0.205360338510422 no 708 0.198554135452555 903 6740226 SGTC_2848 9016370 25.97 µM 0.841703543283007 0.20678348505284 no 709 0.199976957213658 1013 7894410 SGTC_1574 spiramycin 23.7 µM 0.8414643406248 0.206850462902344 no 710 0.200043926950963 1018 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3025 9087895 49.47 µM 0.841387477246524 0.206871987729228 no 711 0.200065449307298 1039 17173641 SGTC_1284 0929-0043 16 µM 0.839903034056647 0.20728795130982 no 712 0.200481378169598 981 1239883 SGTC_3070 9117005 49.47 µM 0.839665091025651 0.207354672531251 no 713 0.200548096124771 957 8779016 SGTC_2061 5245884 80.95 µM 0.838540284103607 0.2076702496645 no 714 0.200863666420996 992 573863 SGTC_483 fpl-64176 144 µM 0.838057016088175 0.207805922997974 no 715 0.200999341180541 959 3423 SGTC_2866 9034245 58.44 µM 0.83753212347217 0.207953341371391 no 716 0.201146764075568 1001 6462273 SGTC_2776 terbinafine 19.92 µM 0.837246904756968 0.208033472172249 no 717 0.201226898631772 1001 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1374 2889-5571 141 µM 0.836229239911635 0.208319528623415 no 718 0.201512975935587 990 2853281 SGTC_1746 st038117 42 µM 0.835822126082988 0.208434029614434 no 719 0.201627488530594 947 2898218 SGTC_1401 3807-4679 7.6 µM 0.83345412953996 0.209100765395501 no 720 0.202294328792507 964 3291456 SGTC_156 3474-0145 5.642 µM 0.833407843501141 0.209113810246066 no 721 0.202307376314634 988 2265471 SGTC_356 1634-0012 32.5 µM 0.832947175914962 0.209243666867028 no 722 0.202437260840669 1031 735457 SGTC_672 1441-0018 53.7 µM 0.830938907751175 0.20981032764043 no 723 0.203004071221373 949 251141 SGTC_38 0929-0051 58.268 µM 0.830627729910624 0.209898211444172 no 724 0.203091982278372 1043 1379719 SGTC_2323 6148992 148.28 µM 0.827382276226452 0.210816091280132 no 725 0.204010211550829 901 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1051 3253-3903 78 µM 0.825695724570021 0.211294010199542 no 726 0.204488359094225 1043 5509239 SGTC_1048 3161-0300 24.5 µM 0.823538805192477 0.21190614141794 no 727 0.205100829642345 1059 2165101 SGTC_2646 retinol 96.75 µM 0.821800456284395 0.212400236916048 no 728 0.205595237007773 1003 445354 A vitamin A analog and teratogen. SGTC_3326 9140064 16.379 µM 0.819833528515092 0.21296011291743 no 729 0.20615550725024 1043 1868434 SGTC_1836 st055642 81 µM 0.819745598450361 0.212985161856991 no 730 0.206180574840374 1047 8571 SGTC_114 0364-0001 490.298 µM 0.81829926163147 0.2133974314386 no 731 0.2065931638134 999 4003655 SGTC_2736 butenafine 14.65 µM 0.816945704986759 0.213783675636767 no 732 0.206979728468499 1022 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_812 4251-0442 148 µM 0.816629883210095 0.213873855516281 no 733 0.207069986119721 1024 5723007 SGTC_688 0527-0193 473 µM 0.812104100225162 0.215168580392316 no 734 0.208365950325145 977 4007154 SGTC_1465 k213-0056 144 µM 0.810272916538704 0.21569373102686 no 735 0.208891668815948 965 24048857 YMR208W ERG12 SGTC_1449 4112-4002 201 µM 0.810220626808446 0.215708737687493 no 736 0.208906692254337 959 2059539 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.806962079492304 0.216645103590754 no 737 0.209844165380442 986 4620898 SGTC_980 1473-0395 201 µM 0.80535298174654 0.21710835464679 no 738 0.210308008013343 977 768876 SGTC_624 k048-0052 28 µM 0.804535795218106 0.217343837457598 no 739 0.210543802616509 989 6835531 SGTC_3241 9133421 49.47 µM 0.803665808771147 0.217594697258453 no 740 0.210795002768357 1059 17018221 SGTC_2174 5790901 200 µM 0.801500486647644 0.218219790914898 no 741 0.211420981226745 1007 786020 SGTC_3353 9151644 39.2805 µM 0.800323140410651 0.21856010564358 no 742 0.211761799636466 1018 4909158 SGTC_1693 xanthone 101.9 µM 0.798243561587398 0.219161958776044 no 743 0.212364581348241 1057 7020 An insecticide. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.796409582614869 0.219693522380559 no 744 0.21289700513924 1165 688664 SGTC_2154 5570129 200 µM 0.79520339608339 0.220043528711983 no 745 0.213247598310569 1087 673366 SGTC_1283 0922-0125 16.4 µM 0.795095522360998 0.220074846649036 no 746 0.21327896954717 1085 3360884 SGTC_949 1165-0505 146 µM 0.794706041448185 0.220187942164251 no 747 0.21339225861761 1062 6244267 SGTC_1087 pterostilbene 9.05 µM 0.793963190262571 0.220403739951214 no 748 0.213608430415781 1059 5281727 Similar to reservatol, lowers cholesterol. SGTC_1353 1498-1206 8.11 µM 0.793933579250486 0.220412344442655 no 749 0.213617049947601 1071 6756808 SGTC_1256 0570-0116 285 µM 0.790267631312098 0.221479097388093 no 750 0.214685743070844 1040 410638 SGTC_2237 6667747 47.222 µM 0.785935333003654 0.222743548067444 no 751 0.215952686670864 983 729940 YDL015C TSC13 SGTC_802 4112-3352 742 µM 0.78564819116695 0.22282750013784 no 752 0.216036811639659 1091 704594 SGTC_1204 4049-0315 18.3 µM 0.784119163616423 0.223274847608119 no 753 0.216485095863872 1020 588402 SGTC_3236 9132701 49.47 µM 0.78349723682543 0.223456950816649 no 754 0.21666758783891 1029 24282524 SGTC_1073 triclabendazole 3.09 µM 0.782751068286195 0.223675544075695 no 755 0.216886653440863 1088 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1104 tacrolimus 29.8 µM 0.78235509426327 0.223791595719901 no 756 0.217002958366582 1087 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_414 piperonyl butoxide 100 µM 0.781133700032276 0.224149776163723 no 757 0.217361931514531 1056 5794 A potent inhibitor of cytochrome P450. SGTC_2589 lobaric acid 100 µM 0.780238644784586 0.224412462523104 no 758 0.217625209762372 1063 73157 A novel microtubule depolymerizer. SGTC_48 0382-0018 55 µM 0.779292400553101 0.224690362039664 no 759 0.217903745124699 1122 762596 SGTC_329 k048-0121 21.3 µM 0.778714073520014 0.224860305156527 no 760 0.218074081975108 1054 6832902 SGTC_1579 chlormadinone acetate 49.4 µM 0.776897489480716 0.225394587440348 no 761 0.218609626273888 1097 45114258 A steroidal progestin. SGTC_339 3091-4833 71.4 µM 0.776694650899068 0.225454289625002 no 762 0.218669471753302 1064 3240077 SGTC_2376 9072922 81.32 µM 0.776562073798774 0.22549331634089 no 763 0.218708592386267 1088 17087968 SGTC_369 0957-0393 4.5 µM 0.776363461123556 0.225551789100997 no 764 0.218767206224963 1068 6997992 SGTC_2864 9034755 47.6 µM 0.776123504471007 0.22562244522068 no 765 0.218838033402192 1103 4930451 SGTC_1402 3909-7673 35.9 µM 0.775623516997509 0.225769708601486 no 766 0.218985655358329 1074 5328014 SGTC_2847 9005661 71.43 µM 0.775356769551768 0.225848297066359 no 767 0.219064436314848 982 2991449 SGTC_306 1672-3436 11.6 µM 0.775343481527889 0.225852212355186 no 768 0.219068361214276 1099 6797378 SGTC_2923 7992654 58.14 µM 0.775034614607676 0.225943230170956 no 769 0.219159602997386 1059 2985126 SGTC_576 1073-0113 22.7 µM 0.774094666056595 0.226220344535138 no 770 0.219437405767509 1266 5439563 SGTC_3295 9122362 53.5725 µM 0.772669917587063 0.226640752867311 no 771 0.219858877163477 1063 4730473 SGTC_2508 celastrol 40.54 µM 0.770317632587116 0.227335818558266 no 772 0.220555749704519 1063 122724 Celastrol is a natural product and antioxidant. SGTC_2792 7535235 81.82 µM 0.770215279167379 0.227366089733398 no 773 0.220586100963048 1030 1281891 SGTC_1772 st048439 82.2 µM 0.770213925085141 0.22736649022044 no 774 0.22058650251037 1064 2927068 YDL195W SEC31 SGTC_315 k915-0449 187 µM 0.769447118857038 0.227593346741559 no 775 0.220813962891393 1109 20970215 YNL149C PGA2 SGTC_64 000l-0018 272.079 µM 0.767440629768078 0.228187561078982 no 776 0.221409789771924 1084 6811119 SGTC_921 1561-0023 372 µM 0.766595221420324 0.22843818657507 no 777 0.221661108751647 1141 24050882 SGTC_1678 st019265 80.2 µM 0.76453479490307 0.229049657584806 no 778 0.22227430485372 1120 5367020 SGTC_635 k038-0028 24.7 µM 0.764107229540721 0.229176660732822 no 779 0.222401672190854 1089 4035102 SGTC_2586 curcumin 80 µM 0.763660647092856 0.229309354833671 no 780 0.222534748958848 1124 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1409 3909-8004 61.9 µM 0.7615624959137 0.229933359698393 no 781 0.223160582877737 1102 2119279 SGTC_2115 tiliquinol 12.7705 µM 0.761289461423802 0.230014631901739 no 782 0.223242096881339 1068 71208 A bioactive hydroxyquinoline. SGTC_1167 k781-0610 148 µM 0.760826749256523 0.230152400788618 no 783 0.223380277537966 1092 4525169 SGTC_1366 1683-0113 21.9 µM 0.760184957424881 0.230343565624523 no 784 0.223572017652388 1116 708623 SGTC_2732 terfenadine 20 µM 0.759957224052857 0.230411419877908 no 785 0.223640077195641 1098 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2791 5663188 71.43 µM 0.75878001634214 0.230762352700869 no 786 0.223992080885489 1063 54690634 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.757856929100096 0.231037739360486 no 787 0.224268318591523 1051 521171 SGTC_1964 st076914 61 µM 0.757466061114071 0.231154403129994 no 788 0.224385345730484 1134 24208661 SGTC_2973 9094665 17.96 µM 0.757116805359763 0.231258674550189 no 789 0.224489943348743 1127 25237061 YIL048W NEO1 SGTC_1068 loratadine 26.9 µM 0.756923220091186 0.231316481350601 no 790 0.224547931569307 1076 3957 A H1 histamine antagonist. SGTC_575 k072-0246 11.9 µM 0.755143928320395 0.231848175763215 no 791 0.225081314019884 1116 6796779 SGTC_347 4534-1311 26.2 µM 0.752003754142616 0.232788192668588 no 792 0.226024400579485 1131 2862016 SGTC_1625 st003711 30.1 µM 0.751879831915637 0.232825332400685 no 793 0.226061663822675 1132 24207034 YER133W GLC7 SGTC_1109 tnp00067 928.257 nM 0.751421765037793 0.232962644505747 no 794 0.226199434038762 1099 676295 SGTC_1297 1068-0111 14.1 µM 0.751048630492282 0.233074530162259 no 795 0.226311694685381 1095 767057 SGTC_3041 9091929 49.47 µM 0.747574449453508 0.234117706069428 no 796 0.227358440506044 1196 25236887 SGTC_2390 9097792 176.6 µM 0.747216389476312 0.234225365815928 no 797 0.227466476236974 1065 4497149 SGTC_137 0438-0332 85.389 µM 0.74453704830576 0.235031846468571 no 798 0.228275818183345 1175 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1074 carmofur 3.8 µM 0.742941166432624 0.235512934330448 no 799 0.22875865041672 1178 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_202 3594-0513 34.79 µM 0.741791414423813 0.235859870210539 no 800 0.229106861598905 1111 708429 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.741675901865074 0.2358947415131 no 801 0.22914186188776 1131 2724 A muscle relaxant with antifungal properties. SGTC_981 1488-1094 54.9 µM 0.741573449368736 0.235925672579933 no 802 0.229172907488885 1104 3449522 SGTC_164 4100-3994 89.624 µM 0.741302614322852 0.236007450184487 no 803 0.229254988461969 1161 4615967 SGTC_1410 3909-8106 77.9 µM 0.739893938128012 0.2364330463677 no 804 0.229682176462899 1143 1039210 SGTC_2051 5263410 176 µM 0.739142571601367 0.236660225562412 no 805 0.229910214265401 1210 227584 SGTC_155 k072-0202 43.6 µM 0.738868285783911 0.236743187075408 no 806 0.229993490869425 1094 5857737 SGTC_700 3453-2283 142 µM 0.73864521453586 0.236810669830553 no 807 0.230061230535395 1160 565664 SGTC_270 tamoxifen 5.46 µM 0.73801921493547 0.237000101579643 no 808 0.23025138637843 1200 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1990 st072050 59.8 µM 0.737110591218694 0.237275205425547 no 809 0.230527549445375 1165 17233948 SGTC_2976 9009005 19.48 µM 0.736613419490809 0.237425808229017 no 810 0.230678735941737 1140 2993148 SGTC_1352 1496-0991 99 µM 0.73409293620865 0.238190117533088 no 811 0.231446049199807 1142 3000039 SGTC_1304 1165-0502 251 µM 0.733950161005231 0.238233452876958 no 812 0.231489556947878 1136 767425 SGTC_2658 polymyxin b sulfate 77.05 µM 0.733865825317813 0.238259052600348 no 813 0.231515258621446 1130 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3180 9109287 49.47 µM 0.733200568346211 0.238461041216687 no 814 0.231718054383093 1118 18891271 SGTC_661 1304-0007 33.6 µM 0.732877831463965 0.238559065951337 no 815 0.231816472570238 1118 3117130 SGTC_2022 5136654 200 µM 0.732192815114787 0.238767198743545 no 816 0.232025444547564 1116 1713771 SGTC_969 1313-0238 134 µM 0.730905822934984 0.239158502109677 no 817 0.232418339532756 1162 5212874 SGTC_285 1486-1325 46 µM 0.730152987278898 0.239387560288402 no 818 0.232648337806099 1129 22310230 SGTC_2412 st077135 33.4 µM 0.729339587736379 0.239635180274272 no 819 0.232896981037372 1144 13258915 SGTC_2567 aureobasidin a 60 nM 0.728782242529674 0.239804931339204 no 820 0.233067437746724 1158 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2185 6113692 200 µM 0.727636482216805 0.240154102409482 no 821 0.233418070969477 1136 874150 SGTC_820 1582-0060 59.9 µM 0.724748471039027 0.24103545361902 no 822 0.234303176530964 1126 3848840 SGTC_157 1348-1695 65.819 µM 0.723053293877598 0.241553598764748 no 823 0.234823571302909 1166 5380510 SGTC_505 gw-5074 63.9 µM 0.723042423754898 0.241556923259631 no 824 0.234826910332933 1136 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2342 7990637 118.86 µM 0.722434580700841 0.241742864202227 no 825 0.235013666286243 1190 2033102 YER133W GLC7 SGTC_513 4245-1575 41.7 µM 0.721858216073174 0.241919247531775 no 826 0.23519082645726 1174 719745 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.719374714221111 0.242680064887634 no 827 0.235955036119574 1188 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2428 5615643 7.78 µM 0.718831779737062 0.242846564497213 no 828 0.236122287069402 1139 2253075 SGTC_1425 4048-4433 7.33 µM 0.717024097169815 0.243401364747011 no 829 0.23667961404235 1213 23734946 SGTC_2346 9031566 143.75 µM 0.716414985845233 0.243588462730086 no 830 0.236867572141039 1125 4771086 SGTC_1254 0550-0035 264 µM 0.715766462955759 0.243787751926169 no 831 0.237067781936614 1190 15121435 SGTC_2 0422-0095 29 µM 0.715375730809354 0.243907865249098 no 832 0.237188452322389 1072 6790840 SGTC_1953 st076800 12.1 µM 0.715352994926938 0.243914855373893 no 833 0.237195474917198 1127 297591 SGTC_1931 st074438 57.1 µM 0.713986726298295 0.244335111678742 no 834 0.237617693689794 1151 2787313 SGTC_408 cantharidin 100 µM 0.712580157110251 0.244768171568288 no 835 0.238052797049141 1128 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1564 D-Arginine 115 µM 0.712392146565029 0.244826088262899 no 836 0.238110988663469 1148 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_708 3448-5400 146 µM 0.712203077026289 0.244884338618568 no 837 0.238169515910054 1172 3462195 SGTC_1723 st034307 2.5525 µM 0.71217304874122 0.244893590706749 no 838 0.238178812013439 1198 867466 SGTC_1268 0828-0275 2.46 µM 0.711775659177252 0.245016049090324 no 839 0.238301853894297 1205 745337 SGTC_1534 6-azauridine 81.6 µM 0.711465170736527 0.245111751202346 no 840 0.238398013207648 1206 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1382 3002-2117 298 µM 0.711136076219462 0.245213210224483 no 841 0.238499958077091 1216 1497314 SGTC_2112 5488546 200 µM 0.710695062548226 0.245349209041795 no 842 0.238636609983715 1163 600757 SGTC_2485 5633444 17.78 µM 0.709700798769827 0.245655966568715 no 843 0.238944848361693 1157 5724239 SGTC_1515 3460-0031 42.1 µM 0.708693378880556 0.245966993069451 no 844 0.239257387269581 1125 2876596 SGTC_2321 7390090 138.78 µM 0.708298869361246 0.246088849797898 no 845 0.239379839543655 1132 649046 SGTC_1018 4259-0013 28.1 µM 0.706052635504582 0.246783286741518 no 846 0.240077702566082 1158 6801262 SGTC_729 4092-0585 94.1 µM 0.705531884499001 0.246944429777239 no 847 0.240239648431476 1175 2169061 SGTC_2860 9025725 38.96 µM 0.70268817341086 0.24782539022954 no 848 0.241125049767967 1156 40546248 SGTC_975 1335-0046 28.5 µM 0.702062130100646 0.248019558859731 no 849 0.241320208958255 1175 16486740 SGTC_286 k060-0067 22.9 µM 0.701038629298383 0.248337174498992 no 850 0.24163945406452 1163 5985051 SGTC_289 k017-0060 526 µM 0.700722541463556 0.248435307565898 no 851 0.241738092875088 1180 5512909 SGTC_446 go6976 132 µM 0.700385160358853 0.248540074168374 no 852 0.241843400600401 1155 3501 A protein kinase C inhibitor. SGTC_2948 9070189 9.45 µM 0.700161231469702 0.248609623567108 no 853 0.241913309903616 1101 6473636 YDL196W YDL196W SGTC_259 usnic acid 108.925 µM 0.697687095878051 0.249378747449968 no 854 0.242686449947231 1267 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3190 9110366 49.47 µM 0.697011582202269 0.249588961070038 no 855 0.242897772744496 1116 17123768 SGTC_2440 5628896 157.78 µM 0.696332617599167 0.24980034340726 no 856 0.243110275391504 1198 5522048 SGTC_1180 1193-0155 285 µM 0.696332468980597 0.249800389687145 no 857 0.243110321917213 1185 2921347 SGTC_3122 9126309 49.47 µM 0.696102293459104 0.249872071903809 no 858 0.24318238517398 1246 17591206 SGTC_2000 st075254 36.4 µM 0.695617228035814 0.250023168735389 no 859 0.243334287061204 1160 17234175 SGTC_1684 st024538 14.6195 µM 0.695564655162228 0.250039547983379 no 860 0.243350753731619 1192 6732859 SGTC_1183 1254-0324 198 µM 0.69456564537324 0.25035090086483 no 861 0.243663774093116 1218 5799357 SGTC_1343 1487-0095 224 µM 0.694253719209968 0.250448158325907 no 862 0.243761554631664 1192 4560101 YGL055W OLE1 SGTC_2153 5569715 200 µM 0.691933700749162 0.251172159647445 no 863 0.244489482765981 1196 2054701 SGTC_3060 1327-0027 12.5 µM 0.691668771277228 0.251254905770396 no 864 0.244572681375661 1138 16000455 YPR107C YTH1 SGTC_1004 4084-0029 199 µM 0.690881996611093 0.251500726124803 no 865 0.244819850424923 1208 716894 YLR208W SEC13 SGTC_3283 9109332 35.8195 µM 0.689571152745039 0.251910569060644 no 866 0.245231956775487 1099 17027281 SGTC_2382 9035899 200 µM 0.687946198505969 0.252419109336649 no 867 0.245743331218032 1243 6462679 SGTC_622 1348-1566 26.3 µM 0.68676103869666 0.252790353949902 no 868 0.246116662746845 1232 7340407 SGTC_2950 9072895 21.46 µM 0.685127409201241 0.253302549990933 no 869 0.24663176280602 1176 17332245 SGTC_316 k060-0003 58.6 µM 0.685023694352146 0.253335086382265 no 870 0.246664484638287 1227 6152314 SGTC_839 0122-0028 230 µM 0.684927035450304 0.253365411229704 no 871 0.246694982425989 1214 759448 SGTC_1764 st044502 93.5 µM 0.6846016349207 0.253467513328832 no 872 0.246797667543011 1215 8407 SGTC_3006 9075424 71.4286 µM 0.684449105009762 0.253515380631442 no 873 0.246845808566333 1200 7465181 SGTC_1330 1469-0054 61.8 µM 0.684137583763942 0.253613157730287 no 874 0.246944145562373 1230 7102664 SGTC_2377 9073351 62.6 µM 0.682980174480969 0.253976606945835 no 875 0.24730968511048 1185 7337946 YHR072W ERG7 SGTC_172 1112-0046 2.638 µM 0.682352553302745 0.254173806528885 no 876 0.247508024874684 1145 2802135 YIL048W NEO1 SGTC_2018 5133068 143 µM 0.679710019790864 0.255004974771963 no 877 0.24834404518189 1220 785362 SGTC_3128 9127691 49.47 µM 0.679656903260059 0.255021696326081 no 878 0.248360865118018 1175 41316314 SGTC_646 4092-0839 27.3 µM 0.678400368491118 0.255417431828382 no 879 0.248758937763528 1253 877796 SGTC_1251 0490-5699 265 µM 0.675062305340798 0.256470284482326 no 880 0.249818090525775 1268 3883818 SGTC_2963 9082507 9 µM 0.674598154421102 0.256616860364034 no 881 0.249965552936334 1236 16459611 SGTC_292 k038-0015 474 µM 0.673787272657532 0.256873036263336 no 882 0.250223283779528 1226 46368540 SGTC_2563 tomatine 8.54 µM 0.673629205185202 0.256922988849969 no 883 0.25027354038812 1233 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1803 st050068 52.4 µM 0.671087747406659 0.257726835406665 no 884 0.251082315975056 1322 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2775 cyproheptadine 69.59 µM 0.670904129837822 0.257784962978061 no 885 0.251140802644507 1245 2913 A selective serotonin reuptake inhibitor. SGTC_639 0833-0042 114 µM 0.670860979555222 0.257798623993409 no 886 0.251154548106495 1226 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1925 st057770 10.1 µM 0.670306233043113 0.257974285517812 no 887 0.251331297265683 1177 5989122 SGTC_3017 9080681 49.47 µM 0.668723923649929 0.258475667664269 no 888 0.251835801831173 1237 16451914 SGTC_1670 st016595 4.04 µM 0.66839609882022 0.258579607725897 no 889 0.251940392530381 1234 597879 SGTC_1034 k072-0165 12.7 µM 0.667613690005185 0.258827765519014 no 890 0.252190108354676 1243 5835461 SGTC_2774 tamoxifen 10.92 µM 0.665269111100107 0.259572136440762 no 891 0.252939191782297 1278 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1090 efavirenz 20.7 µM 0.664709323614166 0.259750024435758 no 892 0.253118214614555 1264 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1037 k284-1091 78.7 µM 0.66421288519524 0.259907834127668 no 893 0.253277033842913 1225 3334711 SGTC_833 3852-0053 558 µM 0.659499622425723 0.26140856350151 no 894 0.254787494230616 1296 3123681 SGTC_789 1309-1135 70.6 µM 0.659243564087831 0.261490221179079 no 895 0.254869688149282 1252 3092424 SGTC_2389 9091542 195.52 µM 0.659043305085161 0.261554093427152 no 896 0.254933980327214 1254 3626624 YOL127W RPL25 SGTC_3027 9089541 49.47 µM 0.657861989690727 0.261931034740482 no 897 0.255313408506137 1251 9943819 SGTC_1863 st057641 20.1 µM 0.655717320005719 0.262616080202686 no 898 0.256003011360819 1269 3921635 SGTC_737 1950-0117 57.9 µM 0.655016046042738 0.262840278260805 no 899 0.256228711508593 1220 5393513 SGTC_609 0986-0026 86.3 µM 0.654988346106683 0.262849135969863 no 900 0.256237628669688 1256 2848610 SGTC_2062 5245942 200 µM 0.654433394877313 0.263026626895494 no 901 0.256416312607103 1318 1376160 SGTC_1441 4106-0040 13 µM 0.653445434309925 0.263342759406113 no 902 0.256734578078408 1251 2904180 SGTC_2488 5268135 45.7 µM 0.649175966919911 0.26471115197758 no 903 0.25811232197191 1284 1270356 YLR208W SEC13 SGTC_1728 st035614 33.7865 µM 0.648748129168469 0.264848475870443 no 904 0.258250594921983 1286 15945546 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.647564959192529 0.265228428629076 no 905 0.258633183619708 1256 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1248 0469-0687 58.6 µM 0.647178174674875 0.265352697192015 no 906 0.258758317502488 1280 4017482 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.646830177557151 0.26546452914464 no 907 0.258870929522452 1244 6708760 SGTC_2283 7944793 200 µM 0.646053509841202 0.265714204399019 no 908 0.259122350951762 1240 2970533 SGTC_2834 9001755 58.44 µM 0.645815766779114 0.265790655418398 no 909 0.259199337923274 1239 2989575 SGTC_2286 7945697 125 µM 0.645210412460688 0.265985369488495 no 910 0.25939541970391 1229 1245733 SGTC_871 0574-0004 149 µM 0.645202743614898 0.265987836659661 no 911 0.259397904229726 1278 9551173 SGTC_887 0885-0007 9.62 µM 0.642231217671949 0.266944688344434 no 912 0.260361533225241 1324 5719458 SGTC_618 k072-0232 33.2 µM 0.641851000608499 0.267067246189229 no 913 0.260484965840235 1273 5872756 YGL099W LSG1 SGTC_752 1896-0090 130 µM 0.640325625999295 0.267559215589782 no 914 0.260980461998861 1277 772567 SGTC_425 3825-7017 13.1 µM 0.640199917649943 0.26759977987629 no 915 0.261021318166568 1356 3397440 SGTC_745 0469-0705 296 µM 0.640185604144082 0.267604398836515 no 916 0.261025970373139 1371 3486736 SGTC_3280 9140961 49.47 µM 0.640103193449206 0.267630993502835 no 917 0.261052756504356 1270 4901226 SGTC_2474 5321570 43.32 µM 0.639327231006893 0.267881468814346 no 918 0.261305038576525 1305 2841384 SGTC_787 4152-0075 138 µM 0.639045251322566 0.267972519147169 no 919 0.261396747250569 1318 9566539 SGTC_2821 7996764 71.43 µM 0.632873892939608 0.269969125312487 no 920 0.263407998832797 1347 2987135 SGTC_452 diindolylmethane 8 µM 0.632175550111141 0.270195526663975 no 921 0.263636085992061 1291 3071 Inhibits expression of several cancer promoting factors. SGTC_1800 st050079 29.0735 µM 0.631499493042502 0.270414793435922 no 922 0.263856990302223 1265 3645560 SGTC_1181 1222-0449 220 µM 0.63100141547212 0.270576392679042 no 923 0.264019799462866 1358 658318 SGTC_3277 9138724 49.47 µM 0.630743747259206 0.270660011012085 no 924 0.264104044875562 1258 15943418 SGTC_998 3996-0085 177 µM 0.630652582053066 0.270689598980155 no 925 0.264133854898936 1318 715391 SGTC_1360 1598-0022 39.8 µM 0.63047908056868 0.270745913920227 no 926 0.264190592717764 1346 761525 SGTC_2549 cedrol 20.94 µM 0.629337160102049 0.27111670321022 no 927 0.264564174169543 1285 6708665 A sedative which affects the nervous system. SGTC_200 k038-0079 37.545 µM 0.629026567642837 0.27121759846787 no 928 0.264665831554446 1292 3436683 SGTC_1310 1188-0297 994 nM 0.628584760094902 0.271361150894115 no 929 0.26481047005875 1245 1588352 SGTC_2340 7987427 183.45 µM 0.62827470823249 0.271461915772021 no 930 0.264911998511369 1296 2239331 SGTC_617 3770-0098 35 µM 0.627792997840035 0.271618505544027 no 931 0.265069776875346 1291 5962639 SGTC_3329 9141233 27.5565 µM 0.626623758426644 0.271998777596631 no 932 0.265452945436502 1308 4909101 YNL103W MET4 SGTC_750 4073-0104 132 µM 0.625030727720244 0.272517305153789 no 933 0.265975445507092 1181 22330957 SGTC_2816 7982706 58.44 µM 0.624904741099028 0.272558334420902 no 934 0.266016790232446 1304 2981853 SGTC_997 3996-0078 137 µM 0.622728526221588 0.273267532188298 no 935 0.266731466810494 1327 735687 SGTC_1671 st016596 74.5 µM 0.622274484467419 0.273415613168236 no 936 0.266880697977904 1318 2829167 SGTC_2314 7727897 200 µM 0.622201527858419 0.27343941090927 no 937 0.266904680762529 1290 900724 SGTC_1372 2752-0194 270 µM 0.621352108810712 0.273716558646947 no 938 0.267183987580889 1280 823334 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.620947246937281 0.273848705521287 no 939 0.267317166563456 1290 6857784 SGTC_1656 st012921 11 µM 0.618632610569268 0.274604807750163 no 940 0.268079206854103 1290 6732821 SGTC_22 0964-0034 14.468 µM 0.61854670552757 0.274632889412648 no 941 0.268107510125754 1280 138402 SGTC_1336 1486-0901 104 µM 0.618044378250017 0.274797124482665 no 942 0.268273042803894 1338 5006114 SGTC_1652 st011932 78 µM 0.616952385467596 0.275154316654354 no 943 0.268633066141861 1308 1551076 SGTC_2638 epoxomicin 18 µM 0.615922140338701 0.275491520556252 no 944 0.268972954101203 1325 9915668 A protesome inhibitor. SGTC_227 fluconazole 33.516 µM 0.614524024853694 0.275949454948874 no 945 0.269434551104037 1270 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1123 mangostin 811.285 nM 0.613150668731937 0.276399643436113 no 946 0.269888359929791 1321 5281650 An antioxidant. SGTC_3066 9117245 49.47 µM 0.613048956727197 0.276432999126892 no 947 0.269921984636421 1391 17176980 SGTC_1689 st020265 53.493 µM 0.612895965494043 0.276483175174404 no 948 0.269972565558301 1365 5758320 YPR016C TIF6 SGTC_1510 1123-0200 71.5 µM 0.612297588084449 0.27667946598729 no 949 0.2701704425783 1422 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1371 2421-0008 32.7 µM 0.612023160888905 0.276769511501281 no 950 0.270261216977876 1338 2827552 SGTC_3192 9110362 49.47 µM 0.611617173576172 0.276902751066546 no 951 0.270395536494445 1388 16649480 SGTC_310 1273-0058 1.06 µM 0.610780509348962 0.277177432012819 no 952 0.27067244918623 1327 2734232 SGTC_2832 7992762 51.95 µM 0.609535193513679 0.277586521989927 no 953 0.271084876336218 1210 2985177 SGTC_1166 k206-0078 225 µM 0.608396784824648 0.277960750572381 no 954 0.271462171694432 1317 5404595 SGTC_413 propylparaben 100 µM 0.60665073445663 0.278535206911365 no 955 0.272041361599041 1288 7175 A pharmaceutical preservative. SGTC_2083 5306046 65.942 µM 0.603713143683369 0.279502986968597 no 956 0.273017187030051 1330 539837 SGTC_221 trifluoperazine 10.304 µM 0.602098258623144 0.280035700410174 no 957 0.273554366806853 1322 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2608 thymoquinone 42.66 µM 0.600787905134444 0.280468317278254 no 958 0.27399063045111 1264 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2945 9067681 61.76 µM 0.600025798921514 0.280720077482457 no 959 0.274244520981235 1404 16456930 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.599151424734734 0.281009059752786 no 960 0.274535955868645 1363 4213774 SGTC_1439 4092-1168 46 µM 0.59745348815025 0.281570641162271 no 961 0.275102325822823 1350 2886240 SGTC_2260 7964312 200 µM 0.597160260809163 0.281667678970103 no 962 0.275200194047693 1394 231951 SGTC_1210 3013-0140 750 nM 0.596517149582186 0.281880560398492 no 963 0.275414900321616 1402 905973 SGTC_1910 st062352 60.4 µM 0.595321701820716 0.28227648105406 no 964 0.275814226086616 1259 2245730 SGTC_678 1218-2179 85.9 µM 0.595129158906547 0.282340274403862 no 965 0.275878569454719 1365 6820081 YOR116C RPO31 SGTC_934 2950-0684 338 µM 0.594914433434093 0.282411425462123 no 966 0.275950334414854 1391 1121253 SGTC_466 geldanamycin 89.2 µM 0.593986866741577 0.282718881398296 no 967 0.276260448533218 1268 5288382 HSP90 inhibitor. SGTC_2714 st079313 56.9 µM 0.593684295329469 0.282819208022247 no 968 0.27636164445307 1347 2939799 SGTC_696 1560-0013 611 µM 0.593412444955776 0.282909362746966 no 969 0.27645258113389 1386 1650269 SGTC_2743 auranofin 4.32 µM 0.592156348783443 0.283326105570734 no 970 0.276872948356157 1330 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1080 nisoldipine 24.4 µM 0.59197213081671 0.28338724945265 no 971 0.276934625356295 1324 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1281 0884-0031 11.8 µM 0.590597053978981 0.283843851664907 no 972 0.277395219637562 1352 1548255 SGTC_1189 1431-2119 7.28 µM 0.589400959811378 0.284241307828807 no 973 0.277796166409719 1374 3107275 SGTC_2450 5739737 12.93 µM 0.587265395720397 0.284951606082676 no 974 0.278512738947009 1355 2262825 SGTC_3059 1327-0034 3 µM 0.584031446358577 0.286028841087713 no 975 0.27959957769033 1314 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_607 4491-0986 66.8 µM 0.582540880445459 0.28652600229149 no 976 0.280101206872503 1421 698981 YDR232W HEM1 SGTC_1732 st034308 51.822 µM 0.582430787416674 0.286562738813718 no 977 0.280138274437104 1350 830119 SGTC_1859 st055998 20 µM 0.580482330547335 0.287213281343928 no 978 0.28079469946421 1439 676301 SGTC_2191 5911152 200 µM 0.579234248564674 0.287630352614292 no 979 0.281215562244811 1369 2875902 SGTC_881 0833-0569 170 µM 0.578147917289323 0.287993604535703 no 980 0.281582129219192 1324 5418700 SGTC_1419 3993-2473 62.6 µM 0.577684282916556 0.28814870241359 no 981 0.281738646152366 1406 704026 SGTC_616 4092-0450 108 µM 0.577306669208419 0.288275053231901 no 982 0.281866154608796 1402 787165 SGTC_1230 0170-0365 3.77 µM 0.577196697682306 0.288311854987028 no 983 0.281903293815356 1432 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_939 1165-0479 45.3 µM 0.574633687793008 0.289170188047525 no 984 0.282769531829653 1313 1377347 SGTC_2572 astragaloside iv 100 µM 0.574141232834051 0.289335245069841 no 985 0.282936116545727 1388 45006101 An anti-inflammatory agent. SGTC_405 ebelactone b 50 µM 0.571213014995858 0.290317614239499 no 986 0.283927628448967 1370 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2048 5246248 200 µM 0.571078014435423 0.290362942360882 no 987 0.283973380507986 1384 677046 SGTC_1937 st074714 47.2 µM 0.569645646014197 0.290844081897628 no 988 0.284459031232772 1333 17250970 SGTC_2220 6782180 200 µM 0.56902830839226 0.291051563479243 no 989 0.284668464516264 1354 833803 SGTC_2783 7738165 71.43 µM 0.568777808287233 0.291135774010349 no 990 0.284753468273639 1312 17201110 SGTC_1846 st056244 14.8 µM 0.566730738327117 0.291824362814571 no 991 0.28544856683681 1420 5393182 SGTC_2009 4012297 12.05 µM 0.566463076069004 0.291914454505568 no 992 0.285539513334122 1381 45595307 SGTC_1158 4092-0494 91.8 µM 0.565623609455133 0.292197092210512 no 993 0.285824837403713 1478 1148199 SGTC_117 lucigenin 22.078 µM 0.564540475647395 0.292561957558845 no 994 0.286193181066382 1346 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_519 k048-0011 62.8 µM 0.564331613126783 0.292632339500694 no 995 0.286264235317169 1423 6836379 SGTC_614 0462-0418 107 µM 0.560686896027594 0.293861790930211 no 996 0.287505500920239 1305 5188303 SGTC_2064 5220758 200 µM 0.558772043646361 0.294508672984906 no 997 0.288158652111177 1420 788518 SGTC_467 ro 31-8220 72.8 µM 0.555994812581965 0.295448052744078 no 998 0.28910720048899 1393 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1385 3091-4834 14.1 µM 0.553131709963052 0.2964179182134 no 999 0.290086612274409 1433 4072814 SGTC_660 4031-1742 102 µM 0.550972354001223 0.297150356058986 no 1000 0.290826313162433 1371 6738706 SGTC_2785 7756463 72.73 µM 0.550398754947154 0.297345055683482 no 1001 0.291022951227828 1356 2201551 SGTC_1825 st052143 62.6 µM 0.550192900794575 0.297414944006838 no 1002 0.291093536155831 1462 674173 SGTC_1969 st069479 40.1 µM 0.549970229279091 0.297490550339333 no 1003 0.291169896557727 1472 3895485 SGTC_415 dibenzyl ketone 100 µM 0.548165738978946 0.298103574051277 no 1004 0.29178905239353 1512 7593 SGTC_976 1348-1067 47.6 µM 0.547218391856234 0.298425638223406 no 1005 0.292114351054518 1427 5310671 YGL099W LSG1 SGTC_2959 9079155 11 µM 0.542399739834616 0.300066253093727 no 1006 0.293771579428566 1412 16189457 SGTC_2856 9022925 19.48 µM 0.542338575188453 0.300087104128281 no 1007 0.293792643075504 1438 4944862 SGTC_3138 9097216 49.47 µM 0.541632835140341 0.300327738379236 no 1008 0.294035733663923 1393 25237486 SGTC_2167 5876490 200 µM 0.541129284044233 0.300499486106257 no 1009 0.294209237536999 1623 686534 SGTC_1696 st025591 34.7925 µM 0.540775832867746 0.300620065279431 no 1010 0.294331051134752 1435 2787147 SGTC_1238 0333-0287 48.8 µM 0.540363552604312 0.300760741471331 no 1011 0.294473169040404 1407 7226 SGTC_2173 5763948 167 µM 0.540056704446669 0.300865461928242 no 1012 0.294578963801088 1422 2867177 SGTC_769 0302-0231 76 µM 0.538974357309929 0.301234974192819 no 1013 0.294952274171123 1433 571869 YER009W NTF2 SGTC_1947 st076332 61.6 µM 0.538473736799865 0.301405954660787 no 1014 0.295125015973712 1426 24208416 SGTC_2367 9070478 135.38 µM 0.535524494917465 0.302414115596008 no 1015 0.296143612099484 1451 572802 SGTC_2556 citropten 84.59 µM 0.535112231183285 0.302555163117545 no 1016 0.296286126330698 1398 2775 A potential DNA crosslinker. SGTC_2057 5236571 38.335 µM 0.533342184061594 0.303161082961858 no 1017 0.296898365782108 1507 54684039 YBR257W POP4 SGTC_1765 st044815 90.4 µM 0.5323679106024 0.303494826160451 no 1018 0.297235602871014 1367 645695 SGTC_462 ag-879 158 µM 0.530940127151182 0.303984218144411 no 1019 0.297730134887712 1504 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_931 2812-0076 566 µM 0.530469802131306 0.304145505375535 no 1020 0.29789312044117 1441 3450959 SGTC_1144 3486-0183 12.5 µM 0.530110772653616 0.304268651997494 no 1021 0.298017565218778 1427 6744069 SGTC_246 cycloheximide 667 µM 0.528837281643634 0.304705636640732 no 1022 0.298459166448894 1382 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_563 tetrahydrosecaminediol 614 µM 0.527106274885697 0.305300059832702 no 1023 0.299059894739409 1529 334274 A psychoactive constituent of the cannabis plant. SGTC_785 1270-0111 65.3 µM 0.52523919857731 0.305941784980907 no 1024 0.299708459267373 1415 6741994 SGTC_1424 4048-1941 275 µM 0.525194115103372 0.305957287816042 no 1025 0.299724127745732 1538 X1424 SGTC_720 r052-1644 49.9 µM 0.524973384997493 0.306033195201399 no 1026 0.299800846462777 1434 1422863 YOR257W CDC31 SGTC_2778 tioconazole 65.09 nM 0.522030407275161 0.307046057532053 no 1027 0.300824579704649 1402 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_584 0986-0246 15.4 µM 0.521204786167301 0.30733047042837 no 1028 0.301112060180718 1521 53315 YDR232W HEM1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.519920465524466 0.307773128126474 no 1029 0.301559505289337 1425 688669 SGTC_932 2857-0803 154 µM 0.519854087701888 0.307796013713709 no 1030 0.301582638819328 1576 674898 SGTC_2256 7954252 200 µM 0.519433594318014 0.307941007788658 no 1031 0.301729204747079 1411 2972920 SGTC_2729 fluphenazine 10.66 µM 0.519030165346699 0.308080145920579 no 1032 0.301869852847636 1383 3372 An atypical antipsychotic. SGTC_55 0767-0285 6.563 µM 0.518283592946364 0.308337703132306 no 1033 0.302130209275686 1406 3116166 SGTC_2830 7992007 71.43 µM 0.516599438019037 0.308919059851997 no 1034 0.302717904042732 1474 1952075 SGTC_1386 3228-0095 33.8 µM 0.515946596814988 0.309144544294196 no 1035 0.302945854077713 1532 870181 SGTC_2986 9022445 71.43 µM 0.514688852358448 0.309579158606208 no 1036 0.303385232267194 1550 6459286 SGTC_1697 st025554 27.742 µM 0.514581956251961 0.309616108908452 no 1037 0.303422588286651 1441 1269519 SGTC_891 0929-0073 133 µM 0.513621615334344 0.309948151950108 no 1038 0.303758282094856 1519 5603632 SGTC_3142 9086498 49.47 µM 0.513355073261739 0.310040337811982 no 1039 0.30385148309258 1412 25236367 SGTC_2132 5317594 122.667 µM 0.513000389435898 0.310163026773457 no 1040 0.303975524139224 1504 794577 SGTC_2826 7992541 19.48 µM 0.512796463671987 0.31023357646502 no 1041 0.304046851863582 1515 2985066 SGTC_2667 digitoxin 100 µM 0.511725432023041 0.310604222752599 no 1042 0.30442159222366 1463 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1001 4048-4355 44.4 µM 0.511155923670921 0.310801387866426 no 1043 0.304620939641695 1437 21824233 SGTC_3150 9097574 49.47 µM 0.509111306907672 0.311509686357777 no 1044 0.305337103386227 1564 17217476 SGTC_937 3122-0005 46.7 µM 0.5078511267133 0.311946587374431 no 1045 0.305778875798424 1520 759535 SGTC_2971 9092186 9.93 µM 0.507701272489048 0.31199855904567 no 1046 0.305831427953942 1366 25236400 SGTC_631 k072-0230 41.5 µM 0.506027848308664 0.312579181483555 no 1047 0.306418550023056 1508 5773147 SGTC_2405 ticlatone 3.52 µM 0.505535236885974 0.312750189982565 no 1048 0.306591477906493 1328 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_612 0302-0167 22.4 µM 0.504236241299846 0.313201325423934 no 1049 0.307047687905847 1563 235821 SGTC_102 gallobenzophenone 83.616 µM 0.50397049176629 0.313293653554409 no 1050 0.307141056554798 1553 70837 SGTC_1900 st060200 72.8 µM 0.502596282755384 0.313771275266206 no 1051 0.307624071648889 1482 688945 SGTC_2291 7917025 104.35 µM 0.500711486009099 0.314426865230322 no 1052 0.308287093742504 1427 2964612 SGTC_2266 7929956 200 µM 0.499780073918165 0.314751055212791 no 1053 0.308614971330512 1460 2967153 SGTC_1634 st006576 41 µM 0.498378904653712 0.315239019237611 no 1054 0.309108501303702 1596 3915356 SGTC_1334 1486-0610 236 µM 0.497934154041729 0.315393973279039 no 1055 0.309265226698984 1503 3742339 SGTC_743 1275-0778 158 µM 0.497606883764979 0.315508017139955 no 1056 0.309380575441444 1576 2849257 YMR203W TOM40 SGTC_135 0933-0004 26.348 µM 0.496064100568609 0.316045867302601 no 1057 0.30992459324508 1430 21230617 YGL099W LSG1 SGTC_3354 9151612 71.43 µM 0.495989568465106 0.316071860803842 no 1058 0.309950885387005 1564 27261949 SGTC_608 k048-0125 159 µM 0.494654041821616 0.316537787440908 no 1059 0.310422173941155 1523 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1663 st014140 55.4 µM 0.492968560169634 0.31712621901362 no 1060 0.311017401167469 1557 4207120 SGTC_702 1488-0190 94 µM 0.492577094064292 0.317262953048076 no 1061 0.311155718128101 1584 949357 SGTC_2543 pimpinellin 60.67 µM 0.492256076006436 0.31737509911061 no 1062 0.311269163542801 1436 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_468 gf-109203x 121 µM 0.492114541198105 0.317424548918787 no 1063 0.311319186595805 1488 2396 A protein kinase C inhibitor. SGTC_2753 fluvastatin 17.09 µM 0.490643840336658 0.31793857902121 no 1064 0.311839186686776 1521 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2214 7179297 48.276 µM 0.488883771541912 0.318554208525922 no 1065 0.312461992797164 1541 769744 SGTC_3023 9089636 49.47 µM 0.48703047821111 0.319202987544756 no 1066 0.31311836617079 1566 17249241 SGTC_3330 9141424 71.43 µM 0.484082563710359 0.320236099714994 no 1067 0.314163637601501 1588 27261020 SGTC_1259 0671-0132 43 µM 0.482494574178128 0.320793197728744 no 1068 0.314727325944718 1492 X1259 SGTC_2208 7283366 200 µM 0.480965968532809 0.321329844197124 no 1069 0.31527034294135 1588 898663 SGTC_546 peri-Naphthalide 147 µM 0.479610900624993 0.321805879036468 no 1070 0.315752046916659 1590 223824 A penicillin ester. SGTC_1845 st056753 3.01 µM 0.479093081520816 0.321987866013773 no 1071 0.315936205684463 1442 5375839 SGTC_554 4483-2211 187 µM 0.478688688024053 0.3221300193778 no 1072 0.316080057200305 1513 747107 SGTC_2069 5228469 200 µM 0.478655640999056 0.322141637297162 no 1073 0.316091813973225 1460 2835210 SGTC_1246 0422-0085 105 µM 0.477295271772004 0.322620035595535 no 1074 0.316575938698909 1574 264295 SGTC_60 0986-0278 202 µM 0.477092754111628 0.322691279714708 no 1075 0.316648037073265 1338 3110598 SGTC_2965 9082772 38.63 µM 0.477050269441367 0.322706226313465 no 1076 0.316663162937838 1621 16459634 SGTC_2439 5492030 7.2 µM 0.476264754198022 0.322982631258242 no 1077 0.316942886019174 1547 5722370 SGTC_3002 9075603 71.4286 µM 0.476100831718983 0.323040324187557 no 1078 0.317001272248748 1498 20105405 SGTC_531 3788-1495 174 µM 0.475431476844345 0.323275949497653 no 1079 0.317239731659525 1502 2896655 SGTC_3260 9137109 49.47 µM 0.474898781302824 0.323463518869067 no 1080 0.317429560068223 1571 17478346 SGTC_2066 5222451 176 µM 0.471396865575326 0.32469770642653 no 1081 0.318678676951518 1472 2281147 SGTC_2955 9076254 12.21 µM 0.470716498401313 0.324937713669084 no 1082 0.318921600521536 1580 16459619 SGTC_1527 coumarin 137 µM 0.47058348204911 0.324984645193283 no 1083 0.318969102807201 1573 323 A hepatotoxic, DNA x-linker. SGTC_1775 st081588 35.1725 µM 0.468369802566532 0.325766094388478 no 1084 0.319760079485161 1519 1426443 YGL099W LSG1 SGTC_2918 7977171 22.06 µM 0.468240303832111 0.325811832385072 no 1085 0.319806376512889 1502 2236483 SGTC_1293 1000-1278 195 µM 0.468230878405219 0.325815161478604 no 1086 0.319809746302149 1584 678847 SGTC_2032 5185112 25.99 µM 0.467639762863978 0.326023973281704 no 1087 0.320021112301065 1532 5718189 SGTC_3238 9133470 49.47 µM 0.465464660088849 0.326792798629389 no 1088 0.320799369473121 1608 3534688 SGTC_1792 st045773 43.6 µM 0.465008914516985 0.326953982660468 no 1089 0.320962536360054 1519 2919270 SGTC_2029 5175081 200 µM 0.464607050992671 0.327096136959965 no 1090 0.321106440987439 1509 1380876 SGTC_73 0327-0325 16.231 µM 0.464479803352745 0.327141154484733 no 1091 0.321152013114315 1614 53298 SGTC_57 miconazole 162.5 nM 0.462952406064437 0.327681711464394 no 1092 0.321699241108901 1465 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3311 9131146 2.8755 µM 0.462584847342624 0.327811847145226 no 1093 0.321830985966424 1528 4900406 YPR165W RHO1 SGTC_386 1509-0011 3.07 µM 0.46252140919395 0.327834309799997 no 1094 0.321853726504793 1527 3107280 SGTC_1929 genistein trimethyl ether 50.5 µM 0.462450544570826 0.327859402813038 no 1095 0.321879129984668 1696 136420 SGTC_2525 harmine 47.85 µM 0.462157386849704 0.327963217598581 no 1096 0.321984229718689 1612 5280953 A monoamine oxidase inhibitor SGTC_1416 3966-0321 25.3 µM 0.461923634746991 0.32804600483372 no 1097 0.322068042197806 1538 582530 YLR208W SEC13 SGTC_3233 9132340 49.47 µM 0.461589877097664 0.328164225356611 no 1098 0.322187727634619 1478 17682950 SGTC_2671 danthron 100 µM 0.461236682609483 0.328289349362205 no 1099 0.322314403200498 1530 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2553 4-methylesculetin 85.09 µM 0.459618188025583 0.3288629695643 no 1100 0.322895150891749 1492 5319502 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.459412389999542 0.328935936587041 no 1101 0.322969026266368 1504 5355888 SGTC_2227 7312221 64.1025 µM 0.459292521463521 0.328978439757483 no 1102 0.323012058727293 1559 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.459167954169539 0.329022611363873 no 1103 0.323056780539185 1655 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3057 9095946 49.47 µM 0.458770524429034 0.329163556048306 no 1104 0.323199481783654 1567 24540043 SGTC_3165 9101544 49.47 µM 0.457883971679444 0.329478051054067 no 1105 0.32351790142341 1572 5002184 SGTC_1669 st015249 58.4 µM 0.457006383035827 0.329789484979001 no 1106 0.323833228792111 1605 722793 SGTC_72 0744-0168 198.391 µM 0.45599786850192 0.330147526945982 no 1107 0.32419575548478 1597 677577 SGTC_2756 carbadox 75.1 µM 0.454754413817925 0.330589191351179 no 1108 0.324642964696835 1513 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3206 9114350 49.47 µM 0.454617949922592 0.330637676535664 no 1109 0.324692059430945 1511 17087243 SGTC_717 1532-0246 73.2 µM 0.452973013437129 0.331222340601992 no 1110 0.325284087033341 1523 9561992 SGTC_2393 9031399 185.94 µM 0.451508548089373 0.331743205830024 no 1111 0.325811532794872 1627 1526623 YDL150W RPC53 SGTC_972 1319-0219 195 µM 0.450998894019268 0.331924550477264 no 1112 0.325995173048309 1510 23903702 SGTC_177 1327-0068 8.361 µM 0.449169644571236 0.332575756434834 no 1113 0.326654641711423 1520 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3157 9099274 49.47 µM 0.448088551216934 0.332960859455471 no 1114 0.327044645154418 1610 17217662 SGTC_2017 5132927 60.65 µM 0.447241136778426 0.333262845496635 no 1115 0.32735048127757 1508 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2698 st077697 67.5 µM 0.447170148975184 0.333288147740839 no 1116 0.327376106397049 1503 3154499 SGTC_579 4491-1009 110 µM 0.446968005808461 0.333360201960675 no 1117 0.327449080328793 1710 1271041 SGTC_1802 st050112 57.9 µM 0.446914523157169 0.333379266956801 no 1118 0.327468388734812 1553 4662563 SGTC_380 3970-0968 6 µM 0.446315168437278 0.333592948761219 no 1119 0.327684800443935 1515 2891601 SGTC_332 4112-0506 40.9 µM 0.446135399176743 0.333657050585376 no 1120 0.327749721830886 1583 2790355 SGTC_2733 amorolfine 100 µM 0.445825002925494 0.33376774259491 no 1121 0.327861829753801 1633 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2427 5545055 42.75 µM 0.442433955312487 0.33497798228579 no 1122 0.329087606215024 1608 5372858 SGTC_2839 9003951 25.97 µM 0.441990066994074 0.335136529976152 no 1123 0.329248196888123 1587 2990634 SGTC_671 0560-0003 407 µM 0.441967843244328 0.335144468610569 no 1124 0.329256237862715 1608 3238678 SGTC_2309 7664088 163.95 µM 0.441503005085087 0.335310532179595 no 1125 0.329424443231727 1678 704922 SGTC_2467 5474540 200 µM 0.439830623309686 0.33590825707872 no 1126 0.330029893153788 1520 5413519 SGTC_1824 st053723 68.6 µM 0.439720164781714 0.335947750626456 no 1127 0.330069897992149 1509 675225 SGTC_2605 digitonin 300 nM 0.439199356621665 0.336133985744422 no 1128 0.330258545601911 1639 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2495 cafestol 54.53 µM 0.437904735006682 0.336597102026047 no 1129 0.330727671515171 1599 16667697 An anti-infammatory. SGTC_1111 tnp00062 510.699 nM 0.437076990534544 0.336893335485304 no 1130 0.331027756829233 1685 676306 SGTC_2933 9026794 32.47 µM 0.436803641461029 0.336991183978134 no 1131 0.33112687895469 1624 17586027 SGTC_2298 7976326 193.81 µM 0.436739383775593 0.337014187368639 no 1132 0.331150181861856 1545 2235818 SGTC_500 h-89 112 µM 0.436378898952863 0.337143247404912 no 1133 0.331280923006817 1713 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1485 3909-9022 254 µM 0.436327099579314 0.33716179408583 no 1134 0.331299711367251 1569 714516 SGTC_687 k029-0044 34.9 µM 0.436290988279797 0.337174723911654 no 1135 0.331312809694069 1692 5829338 SGTC_1596 piperlongumine 63 µM 0.436084595748891 0.337248627448448 no 1136 0.33138767656005 1671 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_139 0099-0334 718.624 µM 0.435861375499849 0.337328563601554 no 1137 0.331468655100829 1604 97690 SGTC_2007 4011539 71.82 µM 0.435038586871243 0.337623271222202 no 1138 0.331767209583653 1551 45595301 SGTC_1897 st060201 15 µM 0.432901350336555 0.338389254722552 no 1139 0.332543219485395 1527 611878 SGTC_3188 9110789 49.47 µM 0.432444908193919 0.338552929974808 no 1140 0.332709042392153 1644 849217 SGTC_1265 0819-1001 68.8 µM 0.431490120655942 0.338895405136651 no 1141 0.33305601724653 1550 3106768 SGTC_1201 1889-3372 45.9 µM 0.431441712861225 0.338912772201523 no 1142 0.333073612706221 1577 5392199 SGTC_2267 7931562 200 µM 0.429910207490744 0.33946240067063 no 1143 0.33363047998274 1480 934880 SGTC_3340 9146634 11.102 µM 0.428394758831675 0.340006603026449 no 1144 0.334181869937392 1577 4907387 SGTC_2156 5649887 115 µM 0.427633564959705 0.34028007604228 no 1145 0.33445896246098 1675 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3151 9099821 49.47 µM 0.427592727308947 0.34029475010186 no 1146 0.334473830879988 1539 17174189 SGTC_2157 5649910 96.377 µM 0.427303893122802 0.34039854284905 no 1147 0.334578998789183 1533 2858091 SGTC_1216 1165-0504 9.65 µM 0.426203592743193 0.340794047187602 no 1148 0.334979749890997 1680 6304004 SGTC_2983 9022671 12.99 µM 0.42613560633151 0.340818490734927 no 1149 0.335004518053537 1722 6405161 SGTC_2770 toltrazuril 17.5 µM 0.425926713569305 0.340893599337615 no 1150 0.335080624366035 1648 68591 Kills coccidiodes. SGTC_3351 9150312 21.596 µM 0.425799067507905 0.340939498323048 no 1151 0.335127133241007 1573 4904905 SGTC_603 3794-0023 45.9 µM 0.42498581447212 0.341231983202759 no 1152 0.335423507895335 1683 3802260 SGTC_2499 avocadenofuran 51.48 µM 0.423357227176862 0.341817988168755 no 1153 0.336017323513834 1519 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1771 st048882 4.1505 µM 0.422634787318616 0.34207806163542 no 1154 0.336280870801893 1518 4580403 SGTC_1782 st039423 80.636 µM 0.42059710340034 0.342812017506424 no 1155 0.337024654622962 1541 2068169 SGTC_165 k038-0023 64.381 µM 0.420082537656627 0.342997453569578 no 1156 0.337212579445777 1544 46368543 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.418923899581328 0.343415134896247 no 1157 0.337635874924653 1633 7104 SGTC_1949 st076024 69.1 µM 0.416898555104021 0.344145717361384 no 1158 0.338376305226426 1543 2921930 SGTC_951 1171-0579 82.7 µM 0.416704293616262 0.344215822021082 no 1159 0.338447356720184 1522 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2178 5812956 200 µM 0.416625787565386 0.344244154631661 no 1160 0.338476072083641 1611 5403383 SGTC_2731 amoxapine 43.43 µM 0.415842815110396 0.344526774980117 no 1161 0.338762513336903 1702 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2226 7298446 200 µM 0.413522869035993 0.345364687786075 no 1162 0.339611785387885 1685 3283010 SGTC_2181 6316240 54.2555 µM 0.412385731578324 0.345775673744017 no 1163 0.340028359829299 1553 12779990 SGTC_1240 0356-0016 42.1 µM 0.410750509613861 0.346366996772551 no 1164 0.340627742981975 1643 4305613 SGTC_2979 9012552 45.46 µM 0.410489843037839 0.346461292731761 no 1165 0.34072332637616 1641 17100905 SGTC_1252 0493-0875 34.8 µM 0.409902806912204 0.346673687496103 no 1166 0.34093862312488 1580 3960963 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.409577267038972 0.346791491428679 no 1167 0.341058037903427 1659 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2935 9038016 29.96 µM 0.409536071382583 0.346806400060586 no 1168 0.34107315045997 1638 6463195 SGTC_2477 5967686 25.23 µM 0.408841390127817 0.347057839632083 no 1169 0.341328031481871 1556 776118 SGTC_2152 5568786 200 µM 0.406733207577041 0.347821307309223 no 1170 0.342101973978295 1623 5399883 SGTC_183 3914-0051 30.55 µM 0.406420497396138 0.347934606384718 no 1171 0.342216830753238 1765 1596232 SGTC_2455 5377712 9.75 µM 0.405307249268738 0.348338061200809 no 1172 0.34262583925557 1545 2243908 SGTC_2107 5363541 170.161 µM 0.4035752304076 0.348966107324233 no 1173 0.343262551605026 1635 244052 SGTC_1503 4585-0012 61.3 µM 0.401616160486556 0.349676983184547 no 1174 0.343983267340524 1690 2922052 SGTC_582 0987-0078 156 µM 0.400899949989061 0.349937001941339 no 1175 0.344246893371639 1621 1625765 SGTC_2996 9066192 71.4286 µM 0.40043372172012 0.350106302991784 no 1176 0.344418545490554 1533 6472854 SGTC_2138 5575593 77.673 µM 0.399983958899397 0.350269653196573 no 1177 0.344584165866998 1593 762213 SGTC_274 sirtinol 40.1 µM 0.399669435737424 0.3503839019171 no 1178 0.344700003383548 1569 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2463 5473429 200 µM 0.39762746416408 0.351125965139534 no 1179 0.345452406398842 1625 5399405 SGTC_1713 st033146 12.748 µM 0.397598694694868 0.351136424180465 no 1180 0.345463011425634 1741 674619 SGTC_1701 st028638 40.4 µM 0.397419719182098 0.351201492640972 no 1181 0.345528988259421 1722 3490878 SGTC_2482 5981709 142.65 µM 0.395195947939987 0.352010331725436 no 1182 0.346349141445379 1662 877755 SGTC_1418 3966-3099 2.4 µM 0.394332261697627 0.352324656052555 no 1183 0.346667873771912 1695 740335 SGTC_1960 st011366 51.8 µM 0.394259478794261 0.352351148799098 no 1184 0.346694738331586 1624 3972846 SGTC_394 menadione 8.33 µM 0.393635154645321 0.3525784302314 no 1185 0.346925211376051 1666 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_20 0481-0013 4.944 µM 0.391991082231912 0.353177196496475 no 1186 0.347532401475245 1594 182045 SGTC_807 1315-0151 48 µM 0.39090218745042 0.353573969025095 no 1187 0.347934768508404 1773 4011080 SGTC_2194 5927483 104.545 µM 0.390450477719494 0.353738610179985 no 1188 0.348101734015457 1661 760979 SGTC_3071 9117417 49.47 µM 0.388987971397993 0.354271858495299 no 1189 0.348642522242897 1749 45595590 YGL055W OLE1 SGTC_2891 9063876 19.48 µM 0.387996692107408 0.354633454078278 no 1190 0.349009240773703 1736 6472478 SGTC_3248 9135562 49.47 µM 0.386867755518281 0.355045423418062 no 1191 0.349427056694513 1662 17650701 SGTC_13 0199-0087 65 µM 0.386007966582751 0.355359289663429 no 1192 0.349745384365981 1687 4589825 SGTC_813 k007-0158 173 µM 0.384379188659059 0.355954144493003 no 1193 0.350348711523315 1740 6523916 SGTC_1227 3909-8010 46.6 µM 0.383955805548202 0.356108828048209 no 1194 0.35050560178583 1658 15982272 SGTC_1059 3448-6867 171 µM 0.383359024551804 0.356326902957033 no 1195 0.350726790258141 1756 3934407 SGTC_2240 6690706 185.951 µM 0.382212448879052 0.35674601491937 no 1196 0.351151894351005 1563 805876 SGTC_2295 7971645 200 µM 0.382102599296264 0.356786177724633 no 1197 0.351192631942111 1712 2978226 YKL099C UTP11 SGTC_854 0422-0053 192 µM 0.382088338461922 0.356791391835503 no 1198 0.351197920681494 1610 3596728 SGTC_2028 5153890 36.43 µM 0.380583190995217 0.357341860940064 no 1199 0.351756277970471 1627 2830968 YPR165W RHO1 SGTC_1992 st073643 23.3 µM 0.377866414990816 0.358336203319692 no 1200 0.352764916431157 1665 3161292 SGTC_572 0960-0087 17.7 µM 0.377463696289793 0.358483680695337 no 1201 0.352914519311614 1581 6796365 SGTC_2690 usnic acid 100 µM 0.3773729420512 0.358516918215491 no 1202 0.352948236048278 1794 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1462 k081-0014 26.5 µM 0.377344856958449 0.358527204220418 no 1203 0.352958670369871 1564 3270634 SGTC_2265 7929201 200 µM 0.37647931627766 0.358844253843267 no 1204 0.353280294786138 1594 1265108 SGTC_451 chloral hydrate 100 µM 0.375550252957623 0.359184680208473 no 1205 0.3536256400815 1708 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_224 benfluorex 43.875 µM 0.375119987695133 0.359342375440906 no 1206 0.353785616295534 1769 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1023 4482-3888 16 µM 0.374758072992736 0.359475038270326 no 1207 0.353920199197303 1760 3303168 SGTC_1902 st060212 70.5 µM 0.37293079068805 0.360145102093978 no 1208 0.354599977405202 1644 688944 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.371990858908756 0.360489942347706 no 1209 0.354949827653002 1585 641818 YHR062C RPP1 SGTC_2841 9004761 38.96 µM 0.371764116790942 0.360573146036253 no 1210 0.355034241238882 1551 2991039 SGTC_1521 st012942 49.4 µM 0.370269121278213 0.361121904138433 no 1211 0.355590989512321 1848 24207259 SGTC_841 0251-0215 91.2 µM 0.369941889234023 0.361242057220242 no 1212 0.355712894500382 1715 3888614 SGTC_2470 5664817 21.68 µM 0.368464792863286 0.361784587762503 no 1213 0.356263346282337 1677 2859561 SGTC_2094 5332512 191.667 µM 0.368257957057286 0.361860579787712 no 1214 0.356340449243357 1774 755774 SGTC_424 splitomicin 100 mM 0.367175576191206 0.362258338170292 no 1215 0.356744028145825 1601 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1020 4335-0961 93.3 µM 0.365685011802674 0.362806341176251 no 1216 0.357300065745868 1596 669075 SGTC_1490 4089-0339 670 nM 0.364065643109027 0.363402017402467 no 1217 0.35790449584355 1786 742542 SGTC_1287 0971-0001 34.6 µM 0.363586594401874 0.363578296344155 no 1218 0.358083369372416 1711 4665869 SGTC_2524 avocatin b 10.57 µM 0.362545744870715 0.363961404632354 no 1219 0.358472122854822 1779 6710748 SGTC_1868 st057644 42.7 µM 0.361477096492273 0.364354886433888 no 1220 0.358871411757734 1649 688665 SGTC_2793 7325131 81.82 µM 0.36109506734928 0.364495586238257 no 1221 0.359014190266718 1724 4176441 SGTC_1633 st005664 67.9 µM 0.359986683880291 0.364903902703786 no 1222 0.359428545832325 1641 2063822 SGTC_875 0709-0210 25.7 µM 0.359240582807785 0.365178844593894 no 1223 0.359707559715458 1761 6251364 SGTC_2727 riluzole 51.77 µM 0.358341630125133 0.365510205112853 no 1224 0.360043833716923 1716 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_159 3970-0959 50 µM 0.358082213278596 0.365605846733369 no 1225 0.36014089473062 1738 6615653 SGTC_732 3970-1727 52.7 µM 0.356462588891228 0.366203157433475 no 1226 0.360747082100107 1835 1275699 SGTC_144 4161-2749 112.381 µM 0.352888548363299 0.367522394418212 no 1227 0.36208599816302 1733 797501 YMR168C CEP3 SGTC_2228 7354201 200 µM 0.352819960868646 0.367547726540456 no 1228 0.362111709155632 1783 753451 SGTC_900 1112-0045 141 µM 0.351120456224066 0.36817560581959 no 1229 0.36274899095921 1681 56211 YIL048W NEO1 SGTC_1479 0549-0158 134 µM 0.350524538693416 0.368395850106325 no 1230 0.362972538818701 1683 5440202 SGTC_2512 diallyl trisulfide 49.23 µM 0.349451479306665 0.368792549566461 no 1231 0.363375195668154 1712 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2093 5331342 194.4 µM 0.345302892551526 0.370327553108959 no 1232 0.364933336158459 1803 33839 SGTC_435 c-PAF 6.7 µM 0.34174140547979 0.3716469763769 no 1233 0.366272754493837 1787 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1076 itraconazole 331 nM 0.339147642801233 0.372608837856967 no 1234 0.367249254595128 1718 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1967 st070177 51.4 µM 0.336130810037933 0.373728588933025 no 1235 0.368386112842367 1776 5729214 SGTC_493 zm226600 134 µM 0.334442873410961 0.374355562609657 no 1236 0.369022695873798 1763 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2206 7254556 146.969 µM 0.333570750192935 0.374679637767402 no 1237 0.369351746587039 1803 4398905 SGTC_1646 st011709 75.6 µM 0.331960088737866 0.375278381379298 no 1238 0.369959698126368 1833 5757843 SGTC_3256 9138902 49.47 µM 0.331208331171037 0.375557941005842 no 1239 0.370243563840601 1810 17228773 SGTC_67 0335-0847 266 µM 0.331110782985955 0.375594221502108 no 1240 0.3702804034866 1932 4552207 YOR254C SEC63 SGTC_2896 9052656 71.43 µM 0.330534271795727 0.375808662215317 no 1241 0.370498150615926 1739 6469436 SGTC_770 0389-1121 67.2 µM 0.330472061536434 0.375831804411517 no 1242 0.370521649788752 1846 6753108 SGTC_679 0422-0091 41.4 µM 0.329903274226967 0.376043413805483 no 1243 0.370736524705004 1665 627384 YHR062C RPP1 SGTC_2867 9039098 71.43 µM 0.329716796672897 0.376112798298301 no 1244 0.370806980466341 1703 6463460 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.32712304467736 0.377078294791576 no 1245 0.371787411345756 1871 6728940 SGTC_2808 7946468 45.46 µM 0.325893031465766 0.37753642328007 no 1246 0.372252644110858 1774 2970879 SGTC_1191 1487-1166 10.6 µM 0.32551433259402 0.377677507506401 no 1247 0.372395918467898 1808 3955771 SGTC_1843 st055809 45.5 µM 0.324918381416501 0.377899562102522 no 1248 0.372621422346978 1745 16413835 SGTC_882 0843-0131 351 µM 0.323718651843923 0.37834671006919 no 1249 0.373075524244715 1829 5425421 SGTC_2481 5478948 45.16 µM 0.323531757883148 0.378416381497733 no 1250 0.373146280166292 1739 77792 SGTC_1712 st032288 53.4 µM 0.322920711437108 0.378644198558638 no 1251 0.373377645230175 1741 2883011 SGTC_2429 5902844 64.44 µM 0.322263224672417 0.378889377118055 no 1252 0.373626645329617 1872 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2068 5226020 147 µM 0.321532543629932 0.379161907197671 no 1253 0.373903427098326 1707 1810509 SGTC_2575 plumbagin 510 nM 0.321439734912043 0.379196527379973 no 1254 0.373938587671542 1665 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_960 1222-0186 7.7 µM 0.321019777577574 0.379353195023983 no 1255 0.374097701572435 1810 3126296 SGTC_3043 9092303 49.47 µM 0.320814919180483 0.379429625889862 no 1256 0.374175326335469 1680 25236084 SGTC_1427 4048-4900 550 nM 0.319999203104215 0.379734009093031 no 1257 0.374484467324547 1860 24132586 SGTC_2385 9074692 200 µM 0.319724811379693 0.379836414706493 no 1258 0.374588474755607 1709 17046906 SGTC_1619 st003326 88.7 µM 0.317786838975442 0.380559924088714 no 1259 0.375323317292853 1849 2849032 SGTC_504 lovastatin 124 µM 0.31699069568009 0.380857272059522 no 1260 0.375625331124705 1690 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2211 7117706 200 µM 0.315364894355447 0.381464703705766 no 1261 0.37624230906168 1831 822771 SGTC_2502 avocadyne acetate 18.59 µM 0.315192979520304 0.38152895160174 no 1262 0.376307567820456 1719 3952079 SGTC_288 1315-0019 35.1 µM 0.314556856314754 0.38176671151026 no 1263 0.376549070509705 1781 6811474 SGTC_2928 9011484 9.79 µM 0.313682245154354 0.38209368243059 no 1264 0.376881193479559 1740 2994751 SGTC_119 0121-0043 24.815 µM 0.31121199059753 0.383017633704114 no 1265 0.377819734084033 1804 1092378 SGTC_520 3584-0023 682 µM 0.310022699116108 0.383462703172609 no 1266 0.378271847406174 1714 1340790 SGTC_1411 3909-8223 150 µM 0.308316397861497 0.384101522147899 no 1267 0.378920794860935 1873 X1411 SGTC_208 k072-0098 12.366 µM 0.308301070661212 0.384107261900133 no 1268 0.378926625714364 1780 5948901 SGTC_79 0052-0007 94.094 µM 0.308210553041048 0.384141159588321 no 1269 0.378961061461075 1861 2801472 SGTC_1864 st057645 30.4 µM 0.307965465936207 0.384232946014473 no 1270 0.379054305117729 1858 688666 SGTC_416 estradiol valerate 100 µM 0.307901136394038 0.384257038846545 no 1271 0.379078780528612 1790 13791 A steroid. SGTC_2773 thioridazine 9.09 µM 0.307495994004203 0.384408783878823 no 1272 0.379232935875847 1806 5452 An antipsychotic. SGTC_2350 9023895 38.85 µM 0.307368764868044 0.384456440878367 no 1273 0.379281350107589 1827 2997209 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.306448389056703 0.384801243673934 no 1274 0.379631635095642 1751 15053 SGTC_2387 9077560 195.08 µM 0.306019535137972 0.384961937479776 no 1275 0.379794885979983 1736 5303272 SGTC_2640 pentamidine 10.38 µM 0.306017246306596 0.384962795169898 no 1276 0.379795757321928 1916 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1638 st008370 60.6 µM 0.304229718064125 0.385632804332305 no 1277 0.380476442734913 1745 24207134 SGTC_3045 9092950 49.47 µM 0.30298182605743 0.386100747167073 no 1278 0.380951855871651 1905 44120432 SGTC_2626 ethyl orsellinate 100 µM 0.301725095182428 0.386572171979922 no 1279 0.38143081807365 1747 75653 A natural product. SGTC_1957 st077035 62.4 µM 0.301404071965068 0.386692621068003 no 1280 0.381553194812825 1817 705593 SGTC_118 0083-0097 135.343 µM 0.300582445410905 0.387000948058739 no 1281 0.381866459647038 1765 5207356 SGTC_1466 k213-0079 57.5 µM 0.29869088181848 0.387711054866567 no 1282 0.382587957447478 1776 3657981 SGTC_1151 3909-8316 15.3 µM 0.298156042007605 0.387911905887029 no 1283 0.382792035076884 1772 800431 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.297421282562387 0.388187882601915 no 1284 0.383072448650723 1877 279621 SGTC_2614 arthonioic acid 13.39 µM 0.293551097542538 0.389642458732222 no 1285 0.384550474286933 1749 6710684 SGTC_431 k089-0097 107 µM 0.293119360573441 0.38980481969886 no 1286 0.384715459395113 1788 5499420 SGTC_1768 st044301 37.178 µM 0.292469676057372 0.390049179245291 no 1287 0.38496377089872 1762 3931349 SGTC_907 3448-6986 75.5 µM 0.291313166645543 0.390484273404063 no 1288 0.385405909201222 1887 590582 SGTC_3139 9095020 49.47 µM 0.290233056228732 0.390890749152685 no 1289 0.38581897441116 1787 25236292 SGTC_1112 tnp00069 1.16933 µM 0.289797977930155 0.391054514993806 no 1290 0.385985397449625 1898 145826 SGTC_354 2783-3500 4.88 µM 0.289092239249742 0.391320199951225 no 1291 0.386255396175567 1720 6740761 SGTC_1154 4088-0362 150 µM 0.287890844232114 0.391772598092539 no 1292 0.386715147802449 1770 6618304 SGTC_2993 9054257 71.4286 µM 0.287741946341546 0.391828677393435 no 1293 0.386772139357512 1786 6470217 YGL055W OLE1 SGTC_641 4092-0595 30 µM 0.287733369549004 0.391831907732851 no 1294 0.386775422250365 1874 786260 SGTC_205 1486-1330 71.903 µM 0.286352771281833 0.392351989509497 no 1295 0.387303971898726 1828 4118834 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.28552392809642 0.392664313441109 no 1296 0.387621387527444 1862 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_129 0088-0017 176.636 µM 0.285148908482468 0.392805650717229 no 1297 0.387765030570451 1922 182446 SGTC_728 3030-5151 22.5 µM 0.283630226095383 0.393378155607531 no 1298 0.388346885440689 1834 3125388 SGTC_3077 9117319 49.47 µM 0.283106718747208 0.393575558164572 no 1299 0.388547515693856 1845 17154678 SGTC_525 k781-2675 26.7 µM 0.282792254188425 0.393694148658215 no 1300 0.38866804617014 1833 3651118 YDL195W SEC31 SGTC_3217 9129673 49.47 µM 0.282738773331556 0.393714318275595 no 1301 0.388688545804977 1815 17248312 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.282692358878482 0.393731823120792 no 1302 0.388706337082679 1974 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_977 1348-1378 135 µM 0.282326352999192 0.393869866874505 no 1303 0.388846640183814 1814 X977 SGTC_2466 5983409 37.09 µM 0.280833146514072 0.394433186637622 no 1304 0.389419189511524 1796 2879657 SGTC_2452 5863136 48.41 µM 0.279830468627686 0.394811576001929 no 1305 0.389803787288579 1787 2184096 SGTC_1440 4100-1550 40 µM 0.279516472944161 0.394930091734758 no 1306 0.389924249014703 1896 742806 SGTC_928 2764-0428 58.7 µM 0.277004046777153 0.395878740743667 no 1307 0.390888499406788 1851 662578 SGTC_262 fenpropimorph 62.5 µM 0.276839768718085 0.395940790872926 no 1308 0.390951571541606 1784 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1500 4488-1866 171 µM 0.275533528626423 0.396434269814204 no 1309 0.391453185089858 1913 2900003 SGTC_1299 1079-1439 3.74 µM 0.275270373855187 0.39653370605661 no 1310 0.3915542618965 1782 323161 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.273508382858774 0.397199668943186 no 1311 0.39223122466618 1886 66535 A nucleotide analog. SGTC_2149 5554786 194.827 µM 0.272349361791403 0.397637896659881 no 1312 0.392676702437968 1822 745063 YPR165W RHO1 SGTC_1365 1672-3266 55.4 µM 0.270903217846369 0.398184867131062 no 1313 0.393232735029413 1931 6415873 SGTC_350 k064-0020 19.8 µM 0.270293701852703 0.3984154624599 no 1314 0.393467155146653 1960 2790705 SGTC_141 0443-0274 32.331 µM 0.269907465067923 0.398561603980342 no 1315 0.393615721979806 1975 1627241 SGTC_2651 TUB2.036 5 µM 0.269281986409712 0.398798298299271 no 1316 0.393856346570341 1937 15992207 YFL037W TUB2 SGTC_2117 5521686 200 µM 0.269042943938645 0.398888766849233 no 1317 0.393948318046535 1778 803312 SGTC_232 clozapine 119 µM 0.268971414414492 0.398915839129631 no 1318 0.393975840146721 1861 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2555 cholic acid 100 µM 0.267947574083135 0.399303392391401 no 1319 0.394369836653522 1855 6708657 Influences liver metabolism. SGTC_477 mead ethanolamide 10 µM 0.266476875425505 0.399860268104549 no 1320 0.394935983245299 1863 16061185 SGTC_2893 9048488 25.97 µM 0.264400526719691 0.400646818041734 no 1321 0.395735652849833 1749 6467338 SGTC_1817 st052116 64.4 µM 0.26320281821594 0.401100710274653 no 1322 0.396197129372097 1916 4361398 SGTC_1270 0831-1170 17.3 µM 0.263101448352271 0.401139132264515 no 1323 0.396236193819833 1846 6764716 SGTC_1818 st052136 56.3 µM 0.263051219544686 0.401158170729977 no 1324 0.396255550655205 1814 674169 SGTC_748 act1.228 77.9 µM 0.262657481420953 0.401307419303949 no 1325 0.396407295625352 1769 4421505 YNR035C ARC35 SGTC_1291 0993-0025 5.79 µM 0.260795150078193 0.402013540908737 no 1326 0.397125242368161 1930 4353356 SGTC_389 tpck 16.7 µM 0.258829644780105 0.40275912896098 no 1327 0.397883341923234 1841 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2904 7225135 42.03 µM 0.258414968498647 0.402916476126388 no 1328 0.39804333281426 1974 4446116 SGTC_800 3448-7362 155 µM 0.257740311861447 0.403172505331383 no 1329 0.398303666259422 1871 15991913 SGTC_3130 9127414 49.47 µM 0.256456778723808 0.403659715007624 no 1330 0.398799075113686 1920 1494646 SGTC_1998 st075797 76.8 µM 0.256440270046692 0.403665982426222 no 1331 0.398805448077717 1963 24208315 SGTC_1014 4130-3005 69.3 µM 0.255440375302766 0.40404563243312 no 1332 0.399191494922194 1804 743608 SGTC_2140 5586273 200 µM 0.255260836652005 0.40411381104179 no 1333 0.399260823001497 1875 854421 SGTC_1002 4049-0206 172 µM 0.254268971900189 0.404490517524429 no 1334 0.399643884523956 1820 4662749 SGTC_2861 9024595 19.48 µM 0.254072647763372 0.404565091199294 no 1335 0.399719717035854 1977 16482810 SGTC_1982 st072467 71.9 µM 0.253446511000913 0.40480295224238 no 1336 0.399961594997217 1817 3163533 SGTC_2961 9083290 32.55 µM 0.252603120648814 0.405123400633056 no 1337 0.400287459142515 1886 17741490 SGTC_92 0063-0024 660.874 µM 0.251414361276303 0.405575180885665 no 1338 0.400746882764004 1984 3594437 SGTC_1816 st051957 91.6 µM 0.251340741354755 0.405603163800393 no 1339 0.400775339411602 1876 674121 SGTC_1770 st043884 66.3 µM 0.249733892127374 0.40621404674972 no 1340 0.401396573168573 1863 670149 SGTC_1399 3562-5772 25 µM 0.248944558222618 0.406514215039941 no 1341 0.401701833771957 1875 23847490 SGTC_1325 1431-0015 227 µM 0.248873672551209 0.40654117416951 no 1342 0.401729250460807 1797 1103340 SGTC_18 0111-0177 500 nM 0.248617551222907 0.406638585530308 no 1343 0.401828315395924 1869 721752 SGTC_218 alverine citrate 93.75 µM 0.247179316949906 0.407185700449303 no 1344 0.402384725717191 1946 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1615 st002656 86.5 µM 0.245845012839658 0.407693441579235 no 1345 0.402901105466251 1853 1584458 SGTC_2665 lovastatin 100 µM 0.244390237613536 0.408247202141409 no 1346 0.403464300925682 1877 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1438 4092-1045 4 µM 0.243580619089936 0.408555463099548 no 1347 0.403777819991646 1874 1351342 SGTC_2292 7671323 168.05 µM 0.242857306584197 0.408830911046075 no 1348 0.404057969964717 1859 937504 SGTC_3309 9129340 25.759 µM 0.242496229777134 0.408968431218327 no 1349 0.404197838948234 1916 17158987 SGTC_1461 k072-0203 53.8 µM 0.241452345447861 0.409366069305946 no 1350 0.404602273374475 1959 5418714 SGTC_203 k066-0004 30.888 µM 0.240809611974303 0.409610946786647 no 1351 0.404851339770063 2022 6795412 SGTC_1484 3473-2379 286 µM 0.240445167422606 0.409749813582062 no 1352 0.404992583235926 1995 671917 SGTC_2706 st078239 82.5 µM 0.239644631817621 0.41005488685423 no 1353 0.40530288078554 1930 15434492 SGTC_2801 7907800 81.82 µM 0.238815776491244 0.410370809760327 no 1354 0.405624218139631 1857 6620925 SGTC_865 0488-0499 301 µM 0.237538525025329 0.410857755219025 no 1355 0.406119517813443 2031 9634651 SGTC_222 nsc-310342 10.666 µM 0.236862020039627 0.411115724928504 no 1356 0.406381917609956 1995 432556 SGTC_2296 7971656 126.45 µM 0.236511569662114 0.411249376289762 no 1357 0.406517865311282 1851 666570 SGTC_1677 st019204 53.9 µM 0.233116895546785 0.412544535063446 no 1358 0.407835317772222 1818 3945625 SGTC_2592 piperlongumine 83.33 µM 0.232988129099583 0.412593681744646 no 1359 0.4078853118726 1819 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1838 st055369 84.5 µM 0.231200962339559 0.413275936279413 no 1360 0.408579341208967 1980 676036 SGTC_2863 9028737 58.44 µM 0.23040618201413 0.4135794295587 no 1361 0.40888807891038 2044 6460917 SGTC_511 blebbistatin 171 µM 0.22959863670014 0.41388785013863 no 1362 0.409201833166861 1993 3476986 A myosin inhibitor. SGTC_179 1273-0063 6.77 µM 0.227175867318429 0.414813480885526 no 1363 0.410143496113092 1845 3108139 SGTC_1748 st037455 53.6035 µM 0.226965226268137 0.414893979747007 no 1364 0.41022539099114 1920 580690 SGTC_2010 4012422 159 µM 0.226883054072853 0.414925383750636 no 1365 0.410257339680928 1923 952393 SGTC_1862 st057513 3.81 µM 0.226664735512878 0.415008821874631 no 1366 0.410342225202668 1898 5393163 SGTC_2200 6600604 21.907 µM 0.226514912779368 0.415066084125527 no 1367 0.410400480953269 1907 2904777 SGTC_2813 7971799 71.43 µM 0.226356985662857 0.415126445825119 no 1368 0.410461890081046 1905 2234054 SGTC_821 1114-0266 29.2 µM 0.2262663470626 0.415161089925525 no 1369 0.410497135415163 1885 3123235 SGTC_3163 9099914 49.47 µM 0.225933595089137 0.415288280827019 no 1370 0.410626534104336 2025 16268368 SGTC_1108 betulinic acid 729.144 nM 0.225842599037764 0.415323064645892 no 1371 0.410661921824232 1883 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1726 st035556 14.5795 µM 0.2255884020766 0.415420236565161 no 1372 0.410760781074573 1989 5919439 SGTC_1681 tripelennamine 100 µM 0.225428639543585 0.415481311665891 no 1373 0.410822916915027 1992 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2049 5262831 67.185 µM 0.225009839111087 0.415641423214158 no 1374 0.410985810008714 1896 763417 SGTC_1354 1498-1681 81 µM 0.223605039535827 0.416178594128894 no 1375 0.41153232098689 1913 5754243 SGTC_3132 9126706 49.47 µM 0.222467071749302 0.416613848078301 no 1376 0.411975151975481 1936 850858 SGTC_1298 1079-1278 263 µM 0.22237436052261 0.416649313108436 no 1377 0.412011234748581 1910 2840950 SGTC_1911 st060208 74.3 µM 0.222018904453292 0.416785292787609 no 1378 0.412149583468997 1977 688783 SGTC_3266 9136860 49.47 µM 0.221097840627279 0.417137691939876 no 1379 0.412508125792976 1900 4871271 YPR165W RHO1 SGTC_397 arbidol 50 µM 0.219005877218811 0.41793832435178 no 1380 0.413322734771234 2004 131410 A RNA synthesis inhibitor. SGTC_2906 7926292 26.41 µM 0.216960232856852 0.418721558671855 no 1381 0.414119668165584 1914 2966319 SGTC_2886 9058944 51.95 µM 0.216533147935971 0.418885121302766 no 1382 0.414286094831434 1954 4949929 SGTC_2378 9074213 121.43 µM 0.215222564854686 0.419387128611353 no 1383 0.414796899463057 1990 657714 SGTC_1050 3232-1156 69.3 µM 0.215160732137384 0.419410816337667 no 1384 0.414821002560923 1880 700529 SGTC_2740 felodipine 17.08 µM 0.21251850902313 0.42042330725744 no 1385 0.415851269722805 2056 3333 L-type calcium channel blocker SGTC_1501 4491-0275 38.4 µM 0.212385516115319 0.420474283667492 no 1386 0.415903142251579 2051 5104718 SGTC_2741 miltefosine 3.04 µM 0.211569727722885 0.420787005912829 no 1387 0.416221364229345 1949 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_711 k292-0785 179 µM 0.210799003800186 0.421082499190605 no 1388 0.41652205796508 1950 4146315 SGTC_2694 st077685 81.9 µM 0.210453861021421 0.421214840336742 no 1389 0.416656729386729 1889 2838096 SGTC_1827 berberine 7.24 µM 0.210118986870223 0.421343252600844 no 1390 0.416787403438145 1797 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1664 st014217 9.02 µM 0.209331533964651 0.421645245581275 no 1391 0.417094718249438 2065 3982782 SGTC_97 0535-0701 19.132 µM 0.208095805151375 0.422119247949826 no 1392 0.417577081236213 1886 2832013 YGL099W LSG1 SGTC_765 1319-0117 244 µM 0.20695168983501 0.42255820971317 no 1393 0.418023793789212 1921 3487746 YGL099W LSG1 SGTC_3118 9124250 49.47 µM 0.206870031067699 0.422589543348001 no 1394 0.418055680986963 1919 1504786 SGTC_45 0kpi-0036 14.9 µM 0.206414845912666 0.422764213360259 no 1395 0.418233437583649 1951 2795021 SGTC_1762 st045503 25.4615 µM 0.206313369039446 0.422803155556301 no 1396 0.418273068095245 1893 4645554 SGTC_2630 antimycin a 100 µM 0.205650202358465 0.423057667242127 no 1397 0.418532079880612 1934 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3009 9080819 71.4286 µM 0.204853879926075 0.423363324185133 no 1398 0.418843144730485 1910 17027216 SGTC_3336 9143619 71.43 µM 0.204366383437067 0.423550465494077 no 1399 0.419033598958478 2041 45595730 SGTC_962 1254-0300 21.5 µM 0.203848746206258 0.423749196180106 no 1400 0.419235849286414 1941 7340576 SGTC_1276 0871-0068 94.2 µM 0.202539634917825 0.424251875108395 no 1401 0.419747438117945 2019 3414906 SGTC_481 bay k-8644 50 µM 0.2019257379144 0.424487644769694 no 1402 0.419987390282523 1902 2303 A calcium channel antagonist. SGTC_1327 1436-0082 2.18 µM 0.201602869558615 0.424611654533844 no 1403 0.420113600854526 1932 15992205 SGTC_2807 7945238 51.95 µM 0.201476864766932 0.424660053449581 no 1404 0.420162858876772 1954 17148797 SGTC_783 0848-0141 92.7 µM 0.197927361233842 0.426023895166119 no 1405 0.421550948235749 1936 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2192 5915882 198.485 µM 0.196697064032654 0.426496825240971 no 1406 0.42203230388755 1990 2876149 SGTC_2857 9024691 58.44 µM 0.196311645303552 0.426645003176833 no 1407 0.422183123549517 1939 16478292 SGTC_2708 st078559 56 µM 0.196072405784975 0.426736986319256 no 1408 0.422276747012872 2046 17250902 SGTC_2111 5486399 200 µM 0.194917065233682 0.427181249253993 no 1409 0.42272893714903 1956 689674 SGTC_2652 actinonin 100 µM 0.19249123307382 0.428114354078766 no 1410 0.423678717250167 2014 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1745 st081495 74 µM 0.191536629315772 0.428481656294889 no 1411 0.424052592840789 1964 13842402 YBL026W LSM2 SGTC_100 0086-0128 49.5915 µM 0.190446602102942 0.428901141049912 no 1412 0.424479591324105 1859 93297 SGTC_2129 girgensonine 121.053 µM 0.190381714643999 0.428926114798872 no 1413 0.424505012615307 1991 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2445 5742597 35.57 µM 0.18973864567304 0.429173633202118 no 1414 0.424756967992437 1940 1774255 SGTC_2843 9000894 45.46 µM 0.187723020256914 0.42994963107363 no 1415 0.425546891761796 2024 2242070 SGTC_1279 0874-0590 65.2 µM 0.186830585302589 0.430293297232454 no 1416 0.425896732761616 2008 3523074 SGTC_2144 5628481 200 µM 0.186247192453015 0.430517983488556 no 1417 0.426125458554583 1962 2818399 SGTC_1934 st074720 32.6 µM 0.185927189763624 0.430641237969316 no 1418 0.426250929803676 1962 17250992 SGTC_952 1185-0122 232 µM 0.185642861143803 0.430750757644526 no 1419 0.426362419715174 2020 678600 SGTC_185 k048-0037 25.491 µM 0.184786092275791 0.431080806007238 no 1420 0.426698408378521 2097 6827589 SGTC_150 3970-0969 77.2 µM 0.183127519125185 0.431719865611579 no 1421 0.427348981868889 1984 6615640 SGTC_1495 4469-0029 237 µM 0.182900711445273 0.43180727009511 no 1422 0.42743796233065 1981 793680 SGTC_1152 3909-8331 15.9 µM 0.182388056311734 0.432004843412116 no 1423 0.427639099143111 1950 16001939 SGTC_2290 7904846 200 µM 0.182375543538217 0.432009665950916 no 1424 0.427644008681438 1935 2962154 SGTC_1812 st052057 4.327 µM 0.182149021692846 0.432096971319211 no 1425 0.427732889209154 2001 3645418 SGTC_666 0272-0154 136 µM 0.181266809262649 0.432437022549065 no 1426 0.42807907840338 2001 6870312 SGTC_255 tunicamycin 200.472 nM 0.18013614634337 0.432872912856121 no 1427 0.428522843028005 2100 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2994 9053520 71.4286 µM 0.179196741234766 0.433235132091958 no 1428 0.428891611215123 2065 4647384 SGTC_2307 7538926 6.34 µM 0.178463782888021 0.433517787808033 no 1429 0.429179380823294 1957 96582 SGTC_2738 aclarubicin 5.55 µM 0.178349709825659 0.433561781641245 no 1430 0.429224170878095 2051 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1160 4092-0570 10.5 µM 0.176897706702991 0.434121838201916 no 1431 0.429794370000189 1912 4994975 SGTC_3185 9108267 49.47 µM 0.17685948465152 0.434136582737709 no 1432 0.429809381717656 1946 4910486 SGTC_1886 st057356 49.9 µM 0.176276161972266 0.434361616610446 no 1433 0.430038494382524 1903 24207747 SGTC_2641 levomentholum 100 µM 0.17578679539082 0.434550420566625 no 1434 0.430230721923639 2063 16666 SGTC_1727 st034309 9.9045 µM 0.175399884148724 0.434699706497044 no 1435 0.430382715805391 2107 870305 SGTC_2329 6138490 200 µM 0.171553715044507 0.436184216266858 no 1436 0.431894198950428 1963 720019 SGTC_1102 cgs 12066b 26.1 µM 0.171551901704503 0.43618491637729 no 1437 0.431894911801136 2004 6438352 A 5-HT1B full agonist. SGTC_1082 camptothecin 424.86 nM 0.171377691400965 0.436252177972251 no 1438 0.431963397475345 1814 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2734 clemastine 41.6 µM 0.169333063772341 0.437041734200253 no 1439 0.432767335179297 2111 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1364 1653-0028 37.6 µM 0.168283566734643 0.437447107044172 no 1440 0.4331801006711 2016 5718652 SGTC_3249 9135183 49.47 µM 0.168224579004551 0.437469893267418 no 1441 0.433203302618339 2046 4902779 SGTC_809 3998-0021 90 µM 0.167311487815103 0.43782263539301 no 1442 0.43356248278911 2127 715485 SGTC_214 4373-3496 70 µM 0.166844580576199 0.438003028441805 no 1443 0.433746170029206 2072 3779166 SGTC_2560 caryophyllene 100 µM 0.16579729443918 0.43840770195685 no 1444 0.43415823768998 2124 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_371 0195-0006 7.36 µM 0.165678001406611 0.438453801123615 no 1445 0.434205179554315 2009 3928593 SGTC_1040 k898-0338 155 µM 0.165600452648623 0.438483769232248 no 1446 0.434235695524636 2158 20969351 SGTC_3068 9116768 49.47 µM 0.164764147537934 0.438806975153365 no 1447 0.434564812209708 2017 41904888 SGTC_440 fluspirilene 35.1 µM 0.164602959904465 0.438869273859006 no 1448 0.434628250665829 2063 3396 An atypical antipsychotic. SGTC_53 0973-0023 39.979 µM 0.164477359382336 0.438917819265494 no 1449 0.434677684304894 2166 674768 SGTC_2504 purpurogallin 52.29 µM 0.164171057853003 0.439036210620162 no 1450 0.434798242218339 1956 5281571 An antioxidant. SGTC_1830 st055982 50.3 µM 0.163231830808295 0.439399273657801 no 1451 0.43516795246944 2146 455313 An antimicrobial agent. SGTC_198 3454-2873 16.191 µM 0.163054856258991 0.439467689795961 no 1452 0.435237621752832 2014 710957 SGTC_1408 3909-7976 48.8 µM 0.161298467484622 0.440146785328503 no 1453 0.435929165113386 2033 24152374 SGTC_1837 st055472 66.5 µM 0.160677134366767 0.440387061740382 no 1454 0.436173849772261 2072 676091 SGTC_1480 1070-0044 41.2 µM 0.15810416447543 0.441382290461087 no 1455 0.437187359555572 2133 3124987 SGTC_619 1652-1634 108 µM 0.158026739150839 0.44141224446563 no 1456 0.437217864324851 2014 5400454 SGTC_2407 paclitaxel 400 µM 0.157954862561752 0.441440052097193 no 1457 0.437246183284368 2037 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1489 4065-0444 182 µM 0.157680224124297 0.441546306937532 no 1458 0.43735439219701 2137 2877968 SGTC_586 0957-0265 8.15 µM 0.156020878707986 0.442188380162403 no 1459 0.438008281962668 2142 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_682 0kpi-0099 17 µM 0.155761072287261 0.442288924412208 no 1460 0.438110677925255 1990 1714895 YML126C ERG13 SGTC_88 0180-0332 8.668 µM 0.155466033548405 0.442403107963607 no 1461 0.438226964816737 2115 3101745 SGTC_2071 5230951 39.92 µM 0.155309794019194 0.442463576484819 no 1462 0.43828854739667 2114 1799272 SGTC_2931 9014674 55.67 µM 0.154514943809951 0.442771223693843 no 1463 0.438601864629577 2058 2996810 SGTC_421 streptovitacin 30 mM 0.153901196097474 0.443008798703211 no 1464 0.438843820495918 1988 91467 include heat shock SGTC_2925 9010536 32.5 µM 0.153334011912993 0.443228367701901 no 1465 0.439067440088525 2040 2994177 SGTC_3154 9100113 49.47 µM 0.15301329958508 0.443352529950092 no 1466 0.439193893623065 2001 25237525 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.15278457976435 0.443441081136311 no 1467 0.439284079260665 2066 364106 SGTC_2124 5246320 200 µM 0.152316887564305 0.443622161678353 no 1468 0.439468502989111 2046 579342 SGTC_880 0833-0487 87.2 µM 0.151870903220229 0.443794848363396 no 1469 0.439644378959099 2035 76075 SGTC_1822 st052468 42 µM 0.151412721667498 0.443972268964397 no 1470 0.439825077359896 2066 2873678 SGTC_845 0330-0138 4.51 µM 0.15114321993423 0.444076632755336 no 1471 0.439931369758444 2137 9039800 SGTC_1651 st011928 86.1 µM 0.149889972649059 0.444562000088039 no 1472 0.440425711503621 2093 720198 SGTC_1941 st076221 61.8 µM 0.148265601200569 0.445191222881769 no 1473 0.441066580770971 2164 2828568 SGTC_3331 9141060 1.957 µM 0.146955451980167 0.445698828035145 no 1474 0.441583591321475 1995 4906567 YPR165W RHO1 SGTC_1198 1612-1005 86.7 µM 0.146955227660998 0.445698914953171 no 1475 0.441583679850763 2132 6998509 SGTC_450 aminopyrene 156 nM 0.146761269751241 0.445774069732221 no 1476 0.441660227925253 2133 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_535 2293-4129 48.2 µM 0.145742194581019 0.446168972762807 no 1477 0.442062455260358 2141 396118 YIL048W NEO1 SGTC_1308 1187-1617 41.4 µM 0.145432482934953 0.446289000089672 no 1478 0.442184709806741 2057 2882570 SGTC_2967 9089538 49.85 µM 0.145404559435998 0.44629982195555 no 1479 0.442195732506759 2170 728216 SGTC_473 2-arachidonoylglycerol 10 µM 0.144564996074179 0.446625216804047 no 1480 0.442527167964974 1978 5282280 An endocannabinoid. SGTC_1513 0337-0559 19 µM 0.143709125218601 0.446956969044514 no 1481 0.442865082559923 1978 775073 SGTC_27 0485-0001 32.618 µM 0.143117554569083 0.44718629507945 no 1482 0.443098670559288 2143 2054479 SGTC_3273 9137859 49.47 µM 0.141309623476569 0.447887259923018 no 1483 0.443812673733914 2194 2377234 SGTC_105 0111-0055 734.78 µM 0.141062804460392 0.447982968421749 no 1484 0.443910163755574 2091 5179370 SGTC_2199 6590217 200 µM 0.140824368240032 0.448075429216871 no 1485 0.444004345914872 2117 703109 SGTC_299 1273-0059 1.44 µM 0.140662137285391 0.448138340747833 no 1486 0.444068428849627 2157 2848077 SGTC_706 4262-0057 46.9 µM 0.140140189554307 0.44834075566484 no 1487 0.444274613610275 2109 883298 SGTC_1700 st030840 7.9285 µM 0.13965879027624 0.448527457537572 no 1488 0.444464793906438 2169 5499307 SGTC_1575 cyproterone acetate 48 µM 0.13937279316368 0.44863838166852 no 1489 0.444577785209331 2021 9880 An androgen receptor antagonist and liver toxin. SGTC_294 k038-0071 157 µM 0.13918261419121 0.448712144906562 no 1490 0.44465292332146 2051 24152826 SGTC_1491 4138-0063 26.5 µM 0.139119834095175 0.448736495323204 no 1491 0.444677727646039 2175 23883227 SGTC_1258 0671-0043 57.1 µM 0.136833844473503 0.449623289313784 no 1492 0.445581065611948 2034 4298767 SGTC_1571 st070080 73.4 µM 0.135427204497487 0.450169086379935 no 1493 0.446137058092414 2123 4315245 SGTC_3152 9099253 49.47 µM 0.135020920568698 0.450326748129886 no 1494 0.446297666786275 2117 25236131 SGTC_2045 5106652 78.05 µM 0.133767941909221 0.450813025849224 no 1495 0.446793038983791 2146 673349 SGTC_422 cantharidin 155 µM 0.133403789629976 0.450954366270584 no 1496 0.446937024253309 2028 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_253 dyclonine 31.25 µM 0.132702717466783 0.451226494750999 no 1497 0.447214246823899 2120 3180 An oral anasthetic. SGTC_3028 9087778 49.47 µM 0.132007664603544 0.451496309407579 no 1498 0.4474891146648 2130 17217395 SGTC_892 0929-0076 29 µM 0.131532502269812 0.451680777003451 no 1499 0.447677038412081 2020 5751038 SGTC_2060 5238662 140 µM 0.131222783336613 0.451801021755639 no 1500 0.447799536649254 2061 790130 SGTC_2616 abietic acid 100 µM 0.131124972368464 0.45183899663892 no 1501 0.447838223311383 2206 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_754 3474-0146 171 µM 0.130639327294369 0.452027553740349 no 1502 0.448030315315517 1966 24762078 SGTC_909 3448-9333 149 µM 0.128967981765845 0.452676554674288 no 1503 0.448691492027644 2079 3344074 SGTC_2471 5466956 24.79 µM 0.128790785785395 0.452745369169034 no 1504 0.448761598342389 2094 724419 SGTC_252 miconazole 1.30953 nM 0.127270419748622 0.453335865177824 no 1505 0.449363185757241 2166 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_633 0437-0093 97.7 µM 0.126912257751645 0.453474987028059 no 1506 0.449504922405631 2144 2831118 SGTC_944 3370-0224 231 µM 0.126471755812506 0.453646100236704 no 1507 0.449679252548458 2072 4580514 SGTC_869 0564-0080 44.1 µM 0.124661559857786 0.454349361803175 no 1508 0.450395745364179 2016 6843321 SGTC_2348 9022543 33.42 µM 0.124310758156966 0.454485664974134 no 1509 0.450534614798289 2103 3162678 YDL140C RPO21 SGTC_816 0325-0417 81.3 µM 0.123893437119716 0.454647821055123 no 1510 0.450699824666367 2069 68101 SGTC_560 2332-1943 155 µM 0.12316705048947 0.454930087021555 no 1511 0.450987408383017 2170 21177716 SGTC_2317 5986382 200 µM 0.123119635417568 0.454948512797026 no 1512 0.451006181379426 2149 877883 SGTC_1504 k297-0033 30 µM 0.122194919067368 0.455307882332811 no 1513 0.451372325149223 2025 4388117 SGTC_1573 oleylamine 1.06 µM 0.122053848931511 0.455362709187896 no 1514 0.451428185870213 2109 5356789 An amine of the fatty acid oleic acid. SGTC_3003 9075612 71.4286 µM 0.121188635936385 0.455698992450752 no 1515 0.451770812491484 2116 6501993 SGTC_1752 st044819 83.042 µM 0.121065860183628 0.45574671441149 no 1516 0.451819434929122 2093 441209 YML126C ERG13 SGTC_346 4513-0042 7.16 µM 0.120343706565205 0.456027422691689 no 1517 0.452105441420354 2128 2827372 SGTC_3207 9114163 49.47 µM 0.119767612467616 0.456251371932744 no 1518 0.452333619365039 2211 849233 SGTC_1872 amphotericin b 148 nM 0.119012137791937 0.456545074140721 no 1519 0.45263286978069 2167 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3088 9117578 49.47 µM 0.1177696673404 0.457028154880482 no 1520 0.453125082104913 2189 678341 SGTC_127 0180-0333 59.125 µM 0.117748421373419 0.457036416007439 no 1521 0.453133499454129 2209 771601 SGTC_950 1165-0508 94.1 µM 0.115880968060248 0.457762615079575 no 1522 0.453873439677771 2085 6148369 SGTC_1026 k007-1105 30.6 µM 0.115460495900167 0.457926144190284 no 1523 0.454040065359673 2178 7066794 SGTC_542 3381-0244 89.3 µM 0.115363990650398 0.457963677806418 no 1524 0.454078309826132 2206 1112843 SGTC_1215 3852-0577 11.2 µM 0.1152423740518 0.458010978468876 no 1525 0.454126506379717 2173 2884876 SGTC_2270 7924575 90.91 µM 0.115202084485817 0.458026648526542 no 1526 0.454142473249109 2224 1262135 SGTC_3120 9124077 49.47 µM 0.113563076381703 0.458664172619585 no 1527 0.454792079357592 2234 18774327 YGL155W CDC43 SGTC_1565 sinapyl alcohol 95.1 µM 0.11174787631837 0.459370354035368 no 1528 0.455511658611356 2092 5280507 A phenol propionate derived from cinnamic acid. SGTC_2786 7743617 45.45 µM 0.11086073842088 0.459715530981449 no 1529 0.455863389916081 2079 583674 SGTC_2104 5389443 200 µM 0.110262421749341 0.45994834748895 no 1530 0.45610062929889 2179 2244536 SGTC_457 grayanotoxin iii 135 µM 0.110166043066895 0.459985851571598 no 1531 0.45613884601134 2132 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_418 lividomycin a 100 µM 0.109894997771574 0.46009132602648 no 1532 0.456246324858153 2231 72394 An antibiotic. SGTC_334 1502-1024 68.5 µM 0.109871242304166 0.460100570353272 no 1533 0.456255744876417 2122 3296216 SGTC_484 loperamide 105 µM 0.109445775082174 0.460266142540208 no 1534 0.456424464258879 2218 3955 An opioid-receptor agonist. SGTC_1373 2887-0003 58.5 µM 0.109105873757875 0.46039842138494 no 1535 0.456559258060041 2127 776948 SGTC_487 nimodipine 119 µM 0.107946335246856 0.46084970998888 no 1536 0.457019130811231 2224 4497 L-type voltage-gated calcium channels inhibitor SGTC_2100 5377183 190 µM 0.107944709628779 0.460850342709663 no 1537 0.4570197755716 2166 2844202 SGTC_3333 9141820 12.094 µM 0.10606728434004 0.461581137288024 no 1538 0.457764483999491 2087 1939433 SGTC_1396 3511-0007 98.6 µM 0.105058226120422 0.461973970609073 no 1539 0.458164803266476 2128 X1396 SGTC_3350 9150499 3.57 µM 0.104637987398485 0.462137583404783 no 1540 0.458331535283016 2220 4910996 YPR165W RHO1 SGTC_1273 0849-0096 14.1 µM 0.104033284617515 0.462373025378807 no 1541 0.458571467284356 2123 5286025 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.10267375308329 0.462902409126326 no 1542 0.459110952766735 2251 16623 A steroid. SGTC_3203 9113543 49.47 µM 0.102383479779834 0.463015446287671 no 1543 0.459226147993101 2141 17018012 SGTC_2602 kawain 100 µM 0.101361896707191 0.463413291096876 no 1544 0.459631591333717 2264 5369129 SGTC_1644 st010134 20.9 µM 0.101066841171166 0.463528204208032 no 1545 0.459748700071424 2235 3818134 SGTC_2146 5545642 200 µM 0.100861875503877 0.46360803247189 no 1546 0.45983005383143 2206 825326 SGTC_2561 acetosyringone 100 µM 0.10028504402063 0.463832699687084 no 1547 0.460059015386977 2262 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2617 dihydrotanshinone i 20.83 µM 0.100215139876354 0.463859927088318 no 1548 0.460086763320291 2180 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3222 9128301 49.47 µM 0.0981853354841805 0.464650601561342 no 1549 0.460892563392279 2174 4911358 SGTC_2027 5150920 200 µM 0.0970960105317785 0.465074986632719 no 1550 0.461325074513981 2206 786715 SGTC_495 decylubiquinone 155 µM 0.0960885413915956 0.465467517250018 no 1551 0.461725125920149 2097 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3116 9124943 49.47 µM 0.09566154975411 0.465633892100567 no 1552 0.461894689825041 2102 41905195 YPL160W CDC60 SGTC_2050 5263056 171 µM 0.094985166522244 0.465897453242879 no 1553 0.462163304522958 2238 763468 YGL055W OLE1 SGTC_1786 berberine 21.6 µM 0.0930514328976777 0.466651038728958 no 1554 0.462931350444974 2264 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1329 1447-1697 50.6 µM 0.0928433034183722 0.466732154983741 no 1555 0.463014024203387 2168 2840515 SGTC_1237 0330-0133 46.1 µM 0.0921730577211813 0.466993385501077 no 1556 0.463280271862226 2196 X1237 YHR072W ERG7 SGTC_454 lyso-paf C-16 6.67 µM 0.0921555994560929 0.467000190109162 no 1557 0.463287207184446 2145 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2520 obtusaquinone 4.71 µM 0.0914504801122718 0.467275028480473 no 1558 0.463567326213807 2228 5967872 SGTC_667 1498-1044 59 µM 0.0907838631214681 0.467534873920874 no 1559 0.463832166230544 2168 6739982 SGTC_1060 3448-7350 82 µM 0.0905983469987463 0.467607190052682 no 1560 0.463905872717987 2238 570178 SGTC_1739 st037196 92.5 µM 0.0884776168294646 0.468433948310026 no 1561 0.464748536871016 2239 612214 SGTC_1161 k007-0610 110 µM 0.0864498284885185 0.469224600950787 no 1562 0.465554418876235 2256 5843850 SGTC_897 1000-0139 31.4 µM 0.0858132913671756 0.469472817592076 no 1563 0.465807420236327 2244 6151020 SGTC_295 k015-0027 31 µM 0.0858096538137199 0.469474236084464 no 1564 0.465808866077083 2191 3887424 SGTC_3341 9147222 25.867 µM 0.0830734999790241 0.470541329127252 no 1565 0.466896548474236 2177 1939759 SGTC_2912 7964298 10.93 µM 0.0815503050050137 0.471135463461044 no 1566 0.467502160228087 2179 2975850 SGTC_3221 9128209 49.47 µM 0.0809443212263039 0.471371850200251 no 1567 0.467743116170823 2200 16460723 SGTC_867 0518-0118 155 µM 0.0803886326579924 0.47158862627043 no 1568 0.467964083734962 2280 6848158 SGTC_2249 haloperidol 116.36 µM 0.0797063929615303 0.471854781886586 no 1569 0.468235387392895 2195 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1317 1273-0028 910 nM 0.0787262137034939 0.472237191772352 no 1570 0.468625197332878 2213 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1597 7-benzyloxygramine 47.5 µM 0.0771397711638804 0.472856184997272 no 1571 0.469256177214649 2226 260807 SGTC_903 1134-0042 114 µM 0.076932547498617 0.472937043756298 no 1572 0.469338602553383 2188 701009 SGTC_3011 9081274 71.4286 µM 0.0763458558795798 0.473165977103432 no 1573 0.469571972278693 2199 6625322 SGTC_2531 methyl deoxycholate 70.07 µM 0.0751220038536607 0.473643565700781 no 1574 0.470058820372757 2207 16667744 Haematoxylin. SGTC_1000 4048-0884 8.67 µM 0.0746095691931004 0.4738435463889 no 1575 0.47026268011599 2203 13040088 SGTC_2735 sertaconazole 140 nM 0.0732984178595303 0.474355260922283 no 1576 0.470784325340232 2299 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_148 3253-0744 288.01 µM 0.0732818748227335 0.474361717590452 no 1577 0.470790907355827 2298 6893655 SGTC_2396 5342950 42.78 µM 0.0732530305422299 0.474372975391333 no 1578 0.470802383714259 2195 1886677 SGTC_2255 7941087 197.44 µM 0.0729649894382677 0.474485397738945 no 1579 0.470916988801174 2291 935561 SGTC_382 3229-0966 23.2 µM 0.0725486165991487 0.474647911509196 no 1580 0.471082658458605 2262 5722370 SGTC_1777 st045864 34.765 µM 0.0715566065191089 0.475035118213726 no 1581 0.471477387242159 2285 4691462 SGTC_2521 angolensin 13.4 µM 0.0714742170726423 0.475067277970718 no 1582 0.471510171930624 2216 821428 A flavenoid. SGTC_95 0471-0001 561.058 µM 0.0705274033794192 0.475436867231752 no 1583 0.471886945054277 2127 4015405 SGTC_3179 9107801 49.47 µM 0.0697549291782509 0.47573841864449 no 1584 0.472194360526421 2260 4818259 SGTC_1683 st010134 710 nM 0.0694536362726079 0.475856038389696 no 1585 0.472314268191027 2284 3818134 SGTC_9 0092-0002 10.449 µM 0.0691786915582883 0.475963374074908 no 1586 0.472423692069854 2286 759368 SGTC_1908 st060353 56.5 µM 0.0688495584812679 0.476091866651692 no 1587 0.472554684841838 2290 4227716 SGTC_686 1319-0111 510 µM 0.0669856271037778 0.476819586447698 no 1588 0.473296572704245 2268 4562600 SGTC_1987 st072290 61.9 µM 0.0659420314762096 0.477227063045014 no 1589 0.473711988553456 2173 54697379 SGTC_1136 pergolide 1.05886 µM 0.0656977098833363 0.477322462963121 no 1590 0.473809247862205 2161 47811 A dopamine receptor agonist. SGTC_1645 Cervolide 78 µM 0.0648846720534024 0.47763993805999 no 1591 0.474132912402287 2232 23173 A fragrance. SGTC_1052 3253-3998 198 µM 0.0645296724668974 0.477778562798271 no 1592 0.474274240564418 2283 5450317 SGTC_2647 atorvastatin 60.16 µM 0.062501050308059 0.47857077596916 no 1593 0.475081912776059 2257 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2483 5729050 27.16 µM 0.0618594402166857 0.478821353938494 no 1594 0.475337383812558 2279 2865180 SGTC_3251 9135047 49.47 µM 0.0602849219267396 0.479436310333578 no 1595 0.475964355331371 2290 17682963 SGTC_545 4218-0007 221 µM 0.0600460256917809 0.479529619861765 no 1596 0.476059488797913 2239 2840508 SGTC_167 3672-0051 66.205 µM 0.0599324586627367 0.47957397794869 no 1597 0.476104714037935 2299 3237971 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0593506168787106 0.479801243185364 no 1598 0.476336422848914 2257 115019 SGTC_1476 4112-3294 3.34 µM 0.059126138115795 0.479888925514616 no 1599 0.476425819925161 2263 704369 SGTC_124 0136-0217 7.121 µM 0.0576464011571919 0.480466941017559 no 1600 0.477015144161255 2320 3976905 SGTC_1460 k062-0059 9.15 µM 0.0551201356549259 0.481453846217686 no 1601 0.478021377298342 2276 1373085 SGTC_439 amiodarone 34.4 µM 0.0542726446850461 0.481784950897628 no 1602 0.478358971900457 2250 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_375 3970-0961 9.27 µM 0.0541340099780654 0.481839115036822 no 1603 0.478414197959841 2262 2898222 SGTC_574 1315-0397 40 µM 0.0541019785191174 0.481851629673693 no 1604 0.478426957963952 2307 6794277 SGTC_2345 9052315 157.45 µM 0.0540954119814522 0.481854195211069 no 1605 0.478429573802814 2239 6469265 SGTC_2966 9084041 48.03 µM 0.0538107278071926 0.481965421653618 no 1606 0.478542981175252 2298 17741380 SGTC_665 3914-0008 307 µM 0.0537157326167237 0.482002536699333 no 1607 0.478580824041493 2285 1069549 SGTC_1035 k081-0041 55.2 µM 0.0502174344269825 0.483369443415765 no 1608 0.479974559209101 2306 731709 SGTC_3008 9078912 71.4286 µM 0.0500462690378287 0.483436328830772 no 1609 0.480042758566425 2292 16648731 SGTC_956 1185-0240 191 µM 0.0499283149343622 0.483482421417921 no 1610 0.480089756690926 2283 1416193 SGTC_1554 st069299 38.7 µM 0.0478782510495463 0.484283553731749 no 1611 0.480906636328459 2268 24207999 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0478629219271095 0.484289544351661 no 1612 0.480912744760489 2238 2374 Ca(2+)-ATPase inhibitor. SGTC_632 0781-2353 4.65 µM 0.0474161235382759 0.48446415468133 no 1613 0.481090789374182 2275 6811515 YHR007C ERG11 SGTC_2828 7998861 71.43 µM 0.0468248852342909 0.484695217195015 no 1614 0.481326397617331 2316 2988188 SGTC_1939 st074455 53.6 µM 0.0468096613186865 0.484701166938981 no 1615 0.481332464428502 2334 1644229 SGTC_298 1391-0729 10 µM 0.0465841388833583 0.484789305026872 no 1616 0.481422336821614 2294 3237558 SGTC_3020 9089140 49.47 µM 0.0447609871918636 0.485501851313695 no 1617 0.482148910808585 2292 17217859 SGTC_2110 5483698 200 µM 0.0420535887372103 0.486560074401252 no 1618 0.483227989118057 2284 2848765 YHR062C RPP1 SGTC_1378 2093-0007 380 nM 0.0412223077626074 0.486885011083345 no 1619 0.483559334881478 2282 3618014 SGTC_2781 5567276 71.43 µM 0.0408242781718093 0.487040598654953 no 1620 0.483717992153868 2311 2853274 SGTC_904 1141-0088 396 µM 0.039459175928535 0.48757422443024 no 1621 0.484262150519868 2279 1378119 SGTC_1335 1486-0900 202 µM 0.0390138229942883 0.48774832013584 no 1622 0.48443968392437 2336 X1335 SGTC_3051 9093778 49.47 µM 0.0375510954925683 0.488320140356444 no 1623 0.48502280026886 2346 17217378 SGTC_153 4077-0274 519.67 µM 0.0367046113887134 0.488651065207396 no 1624 0.485360265882954 2354 3121976 SGTC_2204 7233102 200 µM 0.0365944875439604 0.488694117648715 no 1625 0.48540416944538 2309 2172480 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0364210185536138 0.488761934868028 no 1626 0.485473327457067 2332 688662 SGTC_2798 7813637 45.45 µM 0.0359596128353451 0.48894232172656 no 1627 0.485657281199729 2317 956368 SGTC_3126 9127922 49.47 µM 0.0350825334791693 0.48928522266369 no 1628 0.486006964551475 2295 45595682 SGTC_1916 st067606 49.2 µM 0.0349750571443737 0.489327241915294 no 1629 0.486049815108311 2316 19590279 SGTC_1914 st062367 72.6 µM 0.034127179230497 0.489658734776663 no 1630 0.486387867606306 2326 978205 SGTC_2383 9036125 200 µM 0.0340392136522983 0.489693126887655 no 1631 0.486422940417325 2258 79580 SGTC_2981 9013952 38.96 µM 0.0333647875124035 0.489956811404301 no 1632 0.486691844756957 2254 2996344 SGTC_3317 9138495 8.753 µM 0.0332410516423221 0.490005189654862 no 1633 0.486741180860563 2336 17020139 SGTC_3303 9125618 40.5795 µM 0.0328410599512753 0.490161579408796 no 1634 0.486900667376482 2301 22695467 SGTC_811 0416-0114 265 µM 0.0328335655407954 0.4901645096067 no 1635 0.486903655602169 2245 6612453 SGTC_160 3453-0671 289.699 µM 0.0322031239064296 0.490411004362503 no 1636 0.487155032477814 2343 5322268 SGTC_1783 st039459 87.517 µM 0.0317869041313685 0.490573743076465 no 1637 0.487320995174661 2335 729761 SGTC_3320 9137005 35.139 µM 0.0305497174973465 0.491057482643851 no 1638 0.487814321517775 2217 4908713 SGTC_2355 9061122 103.12 µM 0.03011427498867 0.491227743687543 no 1639 0.487987958050015 2338 5302957 SGTC_1509 1326-1131 80 µM 0.0279545785433028 0.492072223007669 no 1640 0.488849189023117 2341 768313 SGTC_171 k064-0041 9.68 µM 0.026880135930374 0.492492362451658 no 1641 0.489277668511933 2317 53325 SGTC_3137 9097352 49.47 µM 0.0261498073223238 0.492777947731706 no 1642 0.489568925064758 2330 44120435 SGTC_1165 k072-0275 30.3 µM 0.026070666711523 0.492808894838955 no 1643 0.489600486840128 2359 6153523 YGL055W OLE1 SGTC_3244 9134489 49.47 µM 0.025995817430924 0.492838163906288 no 1644 0.489630337265836 2306 16584271 SGTC_3275 9138069 49.47 µM 0.0255428023360379 0.493015311774357 no 1645 0.48981100414276 2258 17617007 SGTC_1249 0481-0015 10.2 µM 0.0253111163283012 0.493105911237764 no 1646 0.489903403612462 2353 4227577 SGTC_2769 toremifene 3.73 µM 0.0243349748801772 0.493487629514173 no 1647 0.490292707732435 2340 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_475 α-linolenic acid 10 µM 0.0242439906743043 0.493523209025868 no 1648 0.490328994473208 2357 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_325 2810-4341 181 µM 0.0227108327739717 0.494122760272485 no 1649 0.490940467380559 2366 774970 SGTC_2882 9058044 58.44 µM 0.0206612850268109 0.494924269585647 no 1650 0.491757926247575 2351 18076804 SGTC_3083 9117465 49.47 µM 0.0199086152806057 0.495218618769007 no 1651 0.492058136253989 2257 16420915 SGTC_2434 5670830 169.91 µM 0.0198676752814081 0.49523462939341 no 1652 0.492074465720843 2344 1549830 SGTC_2023 5144124 124 µM 0.0194531478982461 0.495396741261649 no 1653 0.492239806261412 2352 2830192 SGTC_2566 crystal violet carbinol 226 nM 0.0189765685658939 0.495583121119257 no 1654 0.492429898809906 2302 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_338 4055-0136 114 µM 0.018375174817017 0.495818314563452 no 1655 0.492669778362663 2369 2900563 SGTC_3186 9110464 49.47 µM 0.017855652951046 0.496021490673518 no 1656 0.492877003593105 2367 17018021 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0178414783214494 0.496027034143254 no 1657 0.492882657551494 2373 2346 DNA damaging agent; causes G2/M arrest. SGTC_1709 st033179 39.1045 µM 0.0172885881928421 0.496243261171171 no 1658 0.493103194773561 2378 573381 SGTC_973 1325-0077 65.9 µM 0.0172826451631395 0.496245585406965 no 1659 0.493105565345202 2359 2835149 SGTC_1523 st012844 44.7 µM 0.016210686322913 0.496664815523793 no 1660 0.493533155065802 2281 4274103 SGTC_1448 4255-0083 152 µM 0.0161152531129568 0.496702138481504 no 1661 0.493571222435479 2378 5399660 SGTC_2693 st077581 40.7 µM 0.0161106055935483 0.496703956079812 no 1662 0.4935730762868 2389 25238761 SGTC_1403 3909-7815 62.9 µM 0.015948274924456 0.496767442021844 no 1663 0.493637828534684 2362 6615483 SGTC_2885 9057732 51.95 µM 0.0156130557282711 0.496898543238511 no 1664 0.493771544993917 2347 6471414 SGTC_2927 9011802 47.9 µM 0.0146332095646521 0.497281754140443 no 1665 0.49416240234236 2362 43912568 SGTC_75 0159-0059 199.013 µM 0.0143917613452607 0.497376183229555 no 1666 0.494258716102407 2369 5377270 SGTC_1176 0848-0131 83.3 µM 0.0137041705102139 0.497645097063572 no 1667 0.494532998087249 2374 6769040 SGTC_472 calcifediol 10 µM 0.013333404332451 0.497790102581366 no 1668 0.494680898875239 2338 5283731 A vitamin D metabolite. SGTC_1637 st007924 17.4 µM 0.0126959064502594 0.498039426724558 no 1669 0.494935202191787 2382 683336 SGTC_654 1124-0271 80.9 µM 0.0116090497020295 0.498464495931967 no 1670 0.495368763264135 2375 5403748 SGTC_491 tetrandrine 80.3 µM 0.0111820325297005 0.498631502668374 no 1671 0.495539107406676 2377 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1148 3909-7663 27.7 µM 0.0107697569729196 0.498792744175751 no 1672 0.495703571649464 2383 4084526 SGTC_3314 9135860 59.4275 µM 0.00976737978371237 0.499184775970589 no 1673 0.496103441192032 2380 25252478 SGTC_2168 5727979 200 µM 0.00915059596407411 0.499426001815296 no 1674 0.496349491324052 2383 695210 SGTC_161 4065-0411 162.148 µM 0.00897326251703578 0.499495357455868 no 1675 0.496420234229 2366 1906281 YLR208W SEC13 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.00828085070645181 0.499766161908818 no 1676 0.496696456290916 2397 1241132 A phosphatase inhibitor. SGTC_2289 7946404 165.07 µM 0.00787855446934664 0.499923501299272 no 1677 0.496856944029529 2389 1246120 YPR165W RHO1 SGTC_2369 9071472 200 µM 0.00782817871288181 0.499943203425776 no 1678 0.496877040428951 2386 17296037 SGTC_2595 hexamethylquercetagetin 100 µM 0.00753773591625289 0.499943203425776 no 1679 0.496992906920433 2387 386331 SGTC_1239 0337-0584 35.4 µM 0.00689619192313438 0.499692293455437 no 1680 0.497248839274487 2391 914301 YML130C ERO1 SGTC_65 0798-0905 34.986 µM 0.00686528127906096 0.499680204202932 no 1681 0.497261170545409 2392 3602145 SGTC_490 phenamil 164 µM 0.00673915046926981 0.499630874039934 no 1682 0.497311488294145 2392 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_360 0957-0399 1.01 µM 0.00641373110881442 0.499503601515471 no 1683 0.497441309027943 2389 6752301 YPR165W RHO1 SGTC_2944 9067346 25.62 µM 0.00522442804456887 0.499038461913574 no 1684 0.497915764243525 2393 6473075 SGTC_2358 9037157 4 µM 0.00285914321128218 0.498113397208103 no 1685 0.49885936844135 2396 2388925 SGTC_3258 9138477 49.47 µM 0.00208724313747322 0.49781150845314 no 1686 0.499167311067597 2403 4970355 SGTC_410 α-linolenic acid 100 µM 0.00151901421300896 0.497589275915931 no 1687 0.499394001238947 2395 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1130 3454-2858 15.9 µM 0.00100443499493413 0.497388026253002 no 1688 0.499599288479985 2399 715628 YIL048W NEO1 SGTC_3189 9110682 49.47 µM 0.000582791055267131 0.497223123660796 no 1689 0.499767500020575 2401 17122418 SGTC_59 0330-0160 1.33 µM 0.00043805853677274 0.497166519688322 no 1690 0.49982523993398 2397 4293482 SGTC_1194 1488-0194 225 µM 0 0.49699519811784 no 1691 0.5 2406 1391452 SGTC_3029 9088683 49.47 µM 0 0.49699519811784 no 1692 0.5 2406 25236615 SGTC_2408 sulbentine 18.36 µM -0.000953648869087811 0.496622234803647 no 1693 0.49961954920313 2419 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2991 9074669 71.4286 µM -0.000959685073281199 0.496619874108683 no 1694 0.499617141107167 2408 17333109 SGTC_2037 5169046 200 µM -0.00101890487646454 0.496596713882707 no 1695 0.499593515835404 2412 5718022 SGTC_1469 k284-2957 126 µM -0.00110497132120115 0.496563054245396 no 1696 0.499559180311046 2409 23884841 SGTC_1699 st031318 29.054 µM -0.00364031364498459 0.495571521821031 no 1697 0.49854772818065 2418 5340658 SGTC_69 0096-0274 206.684 µM -0.00456771573433083 0.49520883599058 no 1698 0.498177751405297 2451 6741392 SGTC_1468 k284-1086 134 µM -0.00547559627919032 0.494853788425482 no 1699 0.49781556404951 2419 15996457 SGTC_2430 5571206 200 µM -0.00588415264310258 0.494694014377198 no 1700 0.497652576272246 2420 1731771 SGTC_2424 5537928 59.2 µM -0.0064519671603337 0.494471960696595 no 1701 0.49742605536597 2414 5382802 SGTC_691 1548-0686 185 µM -0.00671367216711405 0.494369617003091 no 1702 0.497321652436168 2425 46495133 SGTC_1951 sophoraflavanone G 9.2 µM -0.00706913524588449 0.494230608395012 no 1703 0.497179846552995 2423 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2777 climbazole 1.536 µM -0.00769773130677514 0.493984789193636 no 1704 0.496929079846518 2423 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3296 9122258 64.045 µM -0.00791574118374156 0.493899534632194 no 1705 0.496842109139484 2425 4730474 SGTC_655 k060-0012 42 µM -0.0083716474022232 0.493721249648442 no 1706 0.496660234905636 2417 5994525 SGTC_1988 st071872 53.4 µM -0.00870037183024174 0.493592700676961 no 1707 0.496529097610935 2417 16414116 SGTC_2878 9043973 25.97 µM -0.00914984021051396 0.493416935390859 no 1708 0.496349792813479 2450 6465167 SGTC_565 1418-0001 44.5 µM -0.00920934115461681 0.493393667552232 no 1709 0.496326056371252 2428 2862145 SGTC_399 oxolinic acid 75 µM -0.0102196913997566 0.492998573678955 no 1710 0.495923003976438 2432 4628 A DNA gyrase inhibitor. SGTC_2746 daunorubicin 9.88 µM -0.0103528020064824 0.492946521752862 no 1711 0.495869903336765 2422 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2108 5365811 200 µM -0.0106658830696135 0.492824094175302 no 1712 0.495745008961249 2438 780283 SGTC_2368 9071271 200 µM -0.0112413790677603 0.492599053332555 no 1713 0.49551543305146 2441 27209959 SGTC_3323 9138564 53.9225 µM -0.0112728790948611 0.492586735690185 no 1714 0.495502867155035 2429 43912313 YNL103W MET4 SGTC_268 camptothecin 39.6153 µM -0.0125670359496319 0.49208068010847 no 1715 0.494986609981823 2429 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2754 granisetron 64.02 µM -0.0127632976578654 0.492003936769247 no 1716 0.494908319167938 2436 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_741 4582-0002 126 µM -0.0130317813498344 0.491898953270232 no 1717 0.494801218580211 2436 2912688 SGTC_3287 9117173 37.0625 µM -0.013079763555044 0.491880191147497 no 1718 0.494782078081197 2427 2789709 SGTC_551 k048-0028 34.9 µM -0.0140461412512154 0.49150231958742 no 1719 0.494396584632456 2435 6836383 SGTC_893 0958-0369 48.9 µM -0.0144402356244147 0.491348223565425 no 1720 0.494239379672305 2445 6819948 SGTC_2089 5281248 129.67 µM -0.0149364703368579 0.491154191182657 no 1721 0.494041432021068 2442 2737878 SGTC_3253 9135987 49.47 µM -0.0154130116460803 0.490967861073146 no 1722 0.493851341433862 2433 4182430 SGTC_1417 3966-0327 90.4 µM -0.0157994909305945 0.490816747125309 no 1723 0.493697177282603 2433 651118 SGTC_384 k007-0144 5.16 µM -0.0164201632579327 0.490574066133168 no 1724 0.493449596981839 2458 6824886 SGTC_2054 5233173 129 µM -0.0164305717416169 0.490569996477203 no 1725 0.493445445157726 2451 6889 SGTC_2338 7999974 200 µM -0.0176315865667122 0.490100413437452 no 1726 0.492966379076826 2464 315925 SGTC_1032 k061-1018 98.7 µM -0.0178445206870784 0.490017160048783 no 1727 0.492881444016406 2477 4005393 SGTC_1660 st012960 28.1 µM -0.017910460904688 0.489991378704714 no 1728 0.492855141879106 2458 24207266 SGTC_3096 9117468 49.47 µM -0.0184995696851925 0.489761050484347 no 1729 0.492620160424511 2424 41316311 SGTC_3310 9130229 44.1445 µM -0.0186690871107548 0.489694773630976 no 1730 0.492552544433791 2491 7761258 SGTC_3172 9105863 49.47 µM -0.0198687774359891 0.489225734516364 no 1731 0.492074026111557 2433 2348785 SGTC_829 1635-0120 117 µM -0.0207810626176757 0.488869071216079 no 1732 0.491710152159774 2461 285054 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0209962164021391 0.488784956855077 no 1733 0.491624336942673 2479 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1954 st077032 68.9 µM -0.0216292208291356 0.488537486713541 no 1734 0.491371862064871 2489 698907 SGTC_3318 9139014 38.6185 µM -0.0217342755305617 0.488496416490225 no 1735 0.491329961152665 2445 16643984 SGTC_1375 2910-0797 186 µM -0.0222351767584804 0.4883005951895 no 1736 0.491130178762696 2459 742508 SGTC_815 1582-0027 36.9 µM -0.0223965640839478 0.488237503357306 no 1737 0.491065810564731 2472 3128206 SGTC_1942 st076330 65.2 µM -0.0227299042209922 0.488107190216239 no 1738 0.490932860937529 2500 24208414 SGTC_1882 5615643 20 µM -0.024740889390256 0.487321060310169 no 1739 0.490130820017699 2440 2253075 SGTC_3271 9137798 49.47 µM -0.0278331948098576 0.486112320251207 no 1740 0.488897595291142 2457 6498326 SGTC_784 4579-0127 173 µM -0.0283553598894483 0.485908225322614 no 1741 0.488689363759495 2527 1948547 SGTC_1303 1160-0052 261 µM -0.0293044557914159 0.485537268487294 no 1742 0.488310886611143 2461 3562476 SGTC_1097 itavastatin 7.23 µM -0.0310905664645265 0.484839196239779 no 1743 0.4875986564525 2479 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1591 genipin 88.4 µM -0.0313735328859381 0.484728607634002 no 1744 0.487485824227448 2551 442424 A DNA cross-linking agent. SGTC_1526 st051518 75 µM -0.0321747434733365 0.484415485849269 no 1745 0.487166348768432 2519 673993 SGTC_2411 st077133 39.94 µM -0.0333214046650553 0.483967374989647 no 1746 0.486709142390907 2655 1403142 YNL221C POP1 SGTC_805 3852-0218 479 µM -0.0347531581533449 0.483407879630449 no 1747 0.486138286212707 2470 6615355 SGTC_373 0844-0104 25.9 µM -0.0355478303313732 0.483097354589478 no 1748 0.485821453683001 2478 5375804 SGTC_1450 4112-4260 37.6 µM -0.0359429530389466 0.482942960771443 no 1749 0.485663923203131 2474 1633175 SGTC_1302 1159-0335 255 µM -0.0372605192437294 0.482428141659072 no 1750 0.485138642348644 2474 649284 SGTC_40 0327-0103 19.753 µM -0.0381353606177475 0.48208632672581 no 1751 0.48478987905489 2491 409036 SGTC_444 curcumin 90.4 µM -0.038887295314617 0.481792543969013 no 1752 0.484490122889244 2505 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1430 4049-0248 69.1 µM -0.0396607346843544 0.481490369599937 no 1753 0.484181803106379 2482 22774488 SGTC_1878 temozolomide 1 mM -0.0403974961299103 0.48120253478493 no 1754 0.483888113210171 2462 5394 DNA alkylating agent. SGTC_2052 5265182 7.135 µM -0.0410546772726753 0.480945798326958 no 1755 0.483626153206539 2495 1239884 SGTC_2363 9053361 176 µM -0.0412452875616406 0.480871335384106 no 1756 0.483550175058245 2506 6469797 YMR079W SEC14 SGTC_507 nimesulide 162 µM -0.0427304665972705 0.480291165202846 no 1757 0.482958196455142 2492 4495 A COX2 inhibitor. SGTC_2865 9030313 51.95 µM -0.0427443064276603 0.480285759007388 no 1758 0.482952680201622 2481 42562754 SGTC_225 nsc-122657 1.016 µM -0.043258903244109 0.480084746773059 no 1759 0.482747575497586 2577 275685 SGTC_2193 5925765 200 µM -0.0450970959550101 0.479366752127621 no 1760 0.48201495808078 2496 877370 SGTC_1720 st037298 9.481 µM -0.0463897825983288 0.478861871090628 no 1761 0.481499790026182 2528 597396 SGTC_1091 telmisartan 47.6 µM -0.0466227139961657 0.478770899303457 no 1762 0.481406964280864 2569 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_151 3013-0144 2.285 µM -0.0468762102802533 0.478671897118914 no 1763 0.481305944345975 2633 906558 YHR107C CDC12 SGTC_3115 9123671 49.47 µM -0.0474007903856582 0.478467028178135 no 1764 0.481096899546698 2483 3286988 SGTC_1195 1502-0147 41.1 µM -0.0475756553975981 0.478398737849266 no 1765 0.481027217115991 2479 817940 SGTC_1025 k007-0731 70 µM -0.048379886281712 0.47808466839847 no 1766 0.480706744476693 2495 6256118 SGTC_1539 benzyladenosine 56 µM -0.0485260808001375 0.478027577752031 no 1767 0.48064848972443 2489 92208 A nucleotide analog. SGTC_2689 tacrolimus 100 µM -0.0487180760199153 0.477952602088281 no 1768 0.480571985199634 2540 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2909 7941780 10.49 µM -0.0488333348092857 0.477907592986932 no 1769 0.480526058259588 2485 1243215 SGTC_2384 9036245 200 µM -0.0494750388890184 0.477657009682047 no 1770 0.480270364456972 2578 6462766 SGTC_184 1494-0393 24.714 µM -0.049640692015957 0.477592324118436 no 1771 0.480204359524082 2486 3090647 SGTC_1212 0520-0165 585 µM -0.0503453838400169 0.477317157012428 no 1772 0.479923579263535 2576 5403258 SGTC_2453 5731132 22.18 µM -0.0510207211627693 0.477053462358276 no 1773 0.479654504474963 2521 1362040 SGTC_2939 9044578 71.43 µM -0.052088466030713 0.476636567380069 no 1774 0.479229101632481 2509 2653634 SGTC_2544 sphondin 68.51 µM -0.0521535240327148 0.476611166670968 no 1775 0.479203182474697 2532 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1318 1280-3875 124 µM -0.0528240264426309 0.476349386802002 no 1776 0.478936058945047 2545 373245 SGTC_1747 st037496 66.6 µM -0.0537149486545737 0.476001565682612 no 1777 0.478581136346263 2514 723305 SGTC_1755 st041960 45.185 µM -0.0546453110932029 0.475638366395019 no 1778 0.478210519816049 2554 2257073 SGTC_1632 st005650 90 µM -0.0558138165031994 0.475182228440426 no 1779 0.477745064062125 2563 2759605 SGTC_2858 9025781 8.96 µM -0.0581256409015927 0.474279880711436 no 1780 0.476824275215632 2549 4894980 YPL153C RAD53 SGTC_636 0kpi-0074 126 µM -0.0582963607055478 0.474213250795695 no 1781 0.476756283161694 2565 616434 SGTC_3133 9127736 49.47 µM -0.0590602773524153 0.473915112045509 no 1782 0.476452048732692 2493 27243420 SGTC_918 glabranin 770.725 nM -0.0602107227413508 0.473466147813179 no 1783 0.475993902849103 2548 124049 Also referred to as licorice root. SGTC_1021 4476-0760 85.3 µM -0.0646481907976811 0.471734735416539 no 1784 0.474227057112322 2526 746768 SGTC_2196 6573537 42.6665 µM -0.0648093861015817 0.471671850047144 no 1785 0.474162884067804 2582 2903087 SGTC_825 1988-2224 89.6 µM -0.0648142808911463 0.471669940507209 no 1786 0.4741609354263 2520 1180859 SGTC_2420 aureobasidin a 50 nM -0.0653316107460905 0.471468125088958 no 1787 0.473954987181186 2735 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1350 1495-0454 146 µM -0.0659718657006088 0.471218365541432 no 1788 0.473700112280844 2585 1069057 SGTC_269 exalamide 29 µM -0.0662610935824421 0.471105543216983 no 1789 0.473584978971955 2557 3316 A derivative of salicylamide. SGTC_1473 k844-0725 134 µM -0.0665766821547371 0.470982440731892 no 1790 0.473459354747263 2519 54682906 SGTC_2606 farnesol 9.78 µM -0.0678172707068605 0.470498547995052 no 1791 0.472965547688821 2561 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2984 9022109 38.96 µM -0.0694162692160367 0.46987492146888 no 1792 0.472329139597436 2503 6459207 SGTC_359 0081-0058 15.9 µM -0.070074361656669 0.469618279751307 no 1793 0.472067236480401 2661 3494159 SGTC_1179 1021-1431 9.29 µM -0.0714995560466031 0.469062528387647 no 1794 0.471500088939446 2607 2840958 SGTC_398 bronopol 33.3 µM -0.0719643215194051 0.468881307111621 no 1795 0.471315150753151 2543 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1891 st059073 26.2 µM -0.072983891997902 0.468483778997007 no 1796 0.470909467823228 2562 688754 SGTC_3114 9122766 49.47 µM -0.0733280248198539 0.468349609497801 no 1797 0.470772545571659 2604 17176985 SGTC_2675 theaflavin digallate 100 µM -0.0763860037853282 0.467157533244545 no 1798 0.469556002216326 2561 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2728 chlorpromazine 9.18 µM -0.0764427327528034 0.467135421631594 no 1799 0.469533436610989 2528 2726 A thorazine and dopamine antagonist. SGTC_3062 9077494 49.47 µM -0.077165199952169 0.466853829858139 no 1800 0.469246062743927 2577 16459633 SGTC_1506 4226-2149 212 µM -0.078427831385611 0.466361741376444 no 1801 0.468743867732481 2621 991114 SGTC_945 3381-0768 11.3 µM -0.0785790079480243 0.466302826391662 no 1802 0.46868374256502 2557 1126236 YIL048W NEO1 SGTC_3022 9087993 49.47 µM -0.0800372599508483 0.465734569429112 no 1803 0.468103810928938 2534 17173644 SGTC_290 2043-6722 48.1 µM -0.0806619707804045 0.465491151139532 no 1804 0.46785539057416 2599 773758 YLR208W SEC13 SGTC_430 0958-0115 16.4 µM -0.0813079953762818 0.465239441531143 no 1805 0.467598507827284 2586 6833180 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0815982533433243 0.465126353270515 no 1806 0.467483095147289 2645 616764 SGTC_2837 9008476 45.46 µM -0.0823256853435382 0.464842948743009 no 1807 0.467193864896376 2684 2992805 SGTC_1725 st036284 20.55 µM -0.0826681807760223 0.4647095200916 no 1808 0.467057693152487 2629 707914 SGTC_304 1310-0298 97 µM -0.0830217868746245 0.464571767133771 no 1809 0.466917107997043 2557 1550234 SGTC_2892 9047358 58.44 µM -0.0870413259532771 0.463006193331047 no 1810 0.465319331689663 2603 6466771 SGTC_995 3931-2021 34.6 µM -0.087724248255366 0.46274025758743 no 1811 0.465047923298465 2632 730143 SGTC_536 3852-0578 10.6 µM -0.089071431186362 0.462215702052502 no 1812 0.464512570869282 2700 2869208 SGTC_1196 1588-0294 184 µM -0.0892732405162182 0.462137128753521 no 1813 0.464432380056665 2631 6144269 SGTC_3268 9137683 49.47 µM -0.0899518709476625 0.461872918764062 no 1814 0.464162730564497 2541 1953228 SGTC_3265 9137266 49.47 µM -0.0911557977624796 0.461404237532139 no 1815 0.46368439847105 2539 17224265 SGTC_3101 9120531 49.47 µM -0.0917828446667465 0.461160153253033 no 1816 0.463435287247548 2596 24824904 SGTC_852 0418-0143 439 µM -0.0931245618387997 0.460637925686747 no 1817 0.46290230234782 2584 5369229 SGTC_3149 9097855 49.47 µM -0.0931581777297516 0.460624842467147 no 1818 0.462888949593101 2658 25236625 YMR079W SEC14 SGTC_1383 3049-0032 20.7 µM -0.0933077472777317 0.460566630894911 no 1819 0.462829538749509 2667 712864 SGTC_2202 7226349 200 µM -0.0935456085755684 0.460474058443537 no 1820 0.462735059057316 2556 844334 SGTC_1307 1187-1599 12.2 µM -0.0940985902021532 0.46025885364195 no 1821 0.462515420134741 2578 1538471 SGTC_215 1287-0124 461.5 µM -0.0941723996801387 0.460230129960879 no 1822 0.462486104591183 2644 5560863 SGTC_2788 5282734 71.43 µM -0.0944025757513394 0.46014055602243 no 1823 0.462394684895652 2657 743706 SGTC_2326 6164455 177.58 µM -0.0946253749475913 0.460053854750962 no 1824 0.4623061969868 2631 2888790 SGTC_1866 st057638 64 µM -0.0949458742072704 0.459929137286374 no 1825 0.462178909364069 2604 688802 SGTC_2702 st077768 96.8 µM -0.0962565938647869 0.45941913161523 no 1826 0.461658392014435 2649 6484119 SGTC_309 k408-0051 1.48 µM -0.0970112601224275 0.459125518532752 no 1827 0.461358726172384 2599 3640463 SGTC_1552 6-methylflavone 10.6 µM -0.0971180277858217 0.459083980930319 no 1828 0.461316332216709 2584 689013 SGTC_2402 5553605 200 µM -0.0980322503033171 0.45872832405155 no 1829 0.460953342329541 2682 6758546 SGTC_3196 9111891 49.47 µM -0.0984928336903339 0.45854915735771 no 1830 0.460770481089686 2543 18891510 SGTC_3095 9117207 49.47 µM -0.0985810132070495 0.45851485653165 no 1831 0.460735472921777 2577 17015229 SGTC_2041 5107442 45.335 µM -0.0989892892760456 0.458356045828513 no 1832 0.460573387127047 2608 793005 SGTC_2817 7995342 71.43 µM -0.0994537882911991 0.458175373680385 no 1833 0.460388988763052 2580 18879975 SGTC_6 0844-0013 19.835 µM -0.0999855880269351 0.457968534767369 no 1834 0.460177883596516 2618 1584900 SGTC_1481 3346-2004 36 µM -0.100248889184926 0.457866130265936 no 1835 0.460073366757463 2584 2770522 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.103792579061713 0.456488174211986 no 1836 0.458666977856275 2666 23847180 SGTC_488 nitrendipine 139 µM -0.103947819350603 0.456427821204505 no 1837 0.458605379134243 2588 4507 Dihydropyridine L-type calcium channel blocker. SGTC_363 0455-0021 3.06 µM -0.104192573086797 0.456332669957748 no 1838 0.458508263856026 2605 4597466 SGTC_2123 5259487 200 µM -0.104397752631269 0.456252905629782 no 1839 0.458426853039358 2658 2173474 SGTC_3220 9131269 49.47 µM -0.105292166179529 0.455905219596469 no 1840 0.458071989453217 2568 17722206 SGTC_23 0213-0011 39.996 µM -0.106458899865523 0.455451725145575 no 1841 0.457609131598008 2674 627608 SGTC_260 nsc-65238 3.989 µM -0.106671002747366 0.455369289687528 no 1842 0.45752499388734 2606 3246252 SGTC_2670 beta-carotene 100 µM -0.106781712563736 0.455326262207198 no 1843 0.457481077887278 2595 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3012 9080433 71.4286 µM -0.107562589243372 0.455022788620655 no 1844 0.457171337110571 2584 17688859 SGTC_1063 disulfiram 1.84 µM -0.108264286293446 0.454750109148226 no 1845 0.456893025733089 2594 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_528 3492-0019 172 µM -0.108483341800059 0.454664988539689 no 1846 0.456806146921651 2577 2869262 SGTC_1923 st058458 19.1 µM -0.10853132227055 0.454646344561921 no 1847 0.456787117836436 2744 3534982 SGTC_1031 k035-0009 16 µM -0.109326823075871 0.454337247984274 no 1848 0.456471636183033 2778 5180959 SGTC_2505 galangin 7.89 µM -0.109636077124709 0.454217092934784 no 1849 0.4563489988519 2576 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3 0833-0587 95.581 µM -0.110246641828336 0.453979881409223 no 1850 0.456106886429714 2572 5382644 SGTC_2899 9053889 58.44 µM -0.110371351347569 0.453931432319071 no 1851 0.456057436303243 2590 6470052 SGTC_1989 st071868 50.2 µM -0.110529224446 0.453870100310118 no 1852 0.455994837048777 2642 16414057 SGTC_3129 9127257 49.47 µM -0.110571387789862 0.45385372048839 no 1853 0.455978118781069 2627 837894 SGTC_2629 bisabolol 100 µM -0.111799817751759 0.453376528588633 no 1854 0.455491066015781 2696 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2451 5856223 45.7 µM -0.112018484401644 0.453291593091973 no 1855 0.455404375190277 2647 2179896 SGTC_3269 9137823 49.47 µM -0.113371780270415 0.452765987421527 no 1856 0.454867905762755 2591 17682936 SGTC_2755 lomerizine 42.69 µM -0.114056626133176 0.452500032074909 no 1857 0.454596452553593 2653 3949 A calcium channel blocker. SGTC_1688 st021091 57.6 µM -0.114314508218586 0.452399890794757 no 1858 0.454494240998047 2590 3656366 SGTC_1933 st074711 15.9 µM -0.115840259745327 0.451807470115894 no 1859 0.453889571308646 2579 17250958 SGTC_2607 solasodine 47.35 µM -0.116357665319408 0.451606595540546 no 1860 0.453684542804479 2641 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3014 9081533 49.47 µM -0.116622012740302 0.451503971591501 no 1861 0.453579796555504 2685 21367265 SGTC_634 1611-4317 11.2 µM -0.116929046423885 0.451384780212752 no 1862 0.453458140157566 2599 2843522 SGTC_2932 9016711 44.54 µM -0.116945282440216 0.451378477465387 no 1863 0.453451707058954 2653 7117328 SGTC_1117 retinoic acid 1.10837 µM -0.117077446382214 0.451327172483022 no 1864 0.453399340993632 2666 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2688 kanamycin b 96.69 µM -0.118337034306842 0.450838251471664 no 1865 0.452900307204626 2689 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3092 9117248 49.47 µM -0.121118467801466 0.449758876886663 no 1866 0.451798600835825 2621 17141857 SGTC_2655 perillic acid 100 µM -0.121776464107374 0.449503586174104 no 1867 0.451538027061804 2618 5702197 An apoptosis inducer. SGTC_2954 9074818 52.69 µM -0.122772384835337 0.449117226663345 no 1868 0.451143671251873 2725 16648742 SGTC_2313 7726885 200 µM -0.123448345324738 0.448855020638359 no 1869 0.450876037889306 2726 726423 SGTC_936 3005-4620 401 µM -0.124371247003438 0.448497061867717 no 1870 0.450510669065978 2711 777207 SGTC_971 1315-0384 26.7 µM -0.124505285414916 0.448445076900629 no 1871 0.450457607893976 2656 6769120 SGTC_699 0375-0592 111 µM -0.125034016925156 0.4482400242478 no 1872 0.450248310017547 2636 762578 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.125290579313679 0.448140529202756 no 1873 0.450146755017023 2714 688761 SGTC_2092 5303694 80.6725 µM -0.125604527462487 0.448018784365122 no 1874 0.450022489473054 2668 1963699 SGTC_1997 st073024 93.8 µM -0.127696720677865 0.447207585769318 no 1875 0.449194492683413 2610 686268 SGTC_217 ketoconazole 989 nM -0.128039546692063 0.447074684029065 no 1876 0.449058838428778 2692 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1033 k072-0102 21.3 µM -0.129161407174112 0.446639819302219 no 1877 0.448614966485545 2632 5965931 SGTC_3084 9116877 49.47 µM -0.13073421594089 0.446030262458077 no 1878 0.447992782110342 2616 27241325 SGTC_1024 4507-0395 26 µM -0.131059293470147 0.44590429145717 no 1879 0.44786420122198 2806 4201836 SGTC_2497 7-hydroxyflavone 100 µM -0.133015949608348 0.445146182175613 no 1880 0.447090383312666 2820 5281894 SGTC_2992 9074591 71.4286 µM -0.13356982535712 0.444931618510006 no 1881 0.446871373105081 2646 17741321 SGTC_2988 9073640 71.4286 µM -0.134132888182504 0.444713512437138 no 1882 0.446648746806805 2794 9102229 SGTC_3047 9092122 49.47 µM -0.134150879973898 0.444706543474526 no 1883 0.446641633408689 2688 17173831 SGTC_1895 st058434 18.3 µM -0.137385853499577 0.443453784723858 no 1884 0.445362906144655 2691 5393175 SGTC_1791 st048313 56.1 µM -0.137477431240967 0.44341832897576 no 1885 0.445326715307029 2703 1204976 SGTC_2618 avocadyne 43.43 µM -0.137506755403413 0.443406975765539 no 1886 0.445315126713917 2680 3015189 SGTC_2203 7227154 166.4 µM -0.137834627024508 0.443280039399772 no 1887 0.445185558565483 2648 896304 SGTC_317 4495-0002 170 µM -0.137858648156033 0.443270739783814 no 1888 0.4451760661364 2695 15991618 SGTC_3347 9188721 44.724 µM -0.137984007496864 0.443222208283838 no 1889 0.445126528403517 2736 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_212 3807-4682 38.772 µM -0.138965461460784 0.442842278592442 no 1890 0.444738720970331 2724 3125501 YBL034C STU1 SGTC_1105 epirubicin 18.1 µM -0.139126209153769 0.442780056708303 no 1891 0.444675208859782 2650 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_146 3448-8650 53.125 µM -0.139422116485441 0.442665521202182 no 1892 0.444558298304971 2687 2891488 YIL048W NEO1 SGTC_3313 9133968 57.047 µM -0.139544987061992 0.442617963653847 no 1893 0.444509754566591 2631 1494643 SGTC_689 0833-0039 98 µM -0.139615167878058 0.442590800259115 no 1894 0.444482027885501 2720 5374726 SGTC_966 1300-0360 30.2 µM -0.139997632254607 0.442442772659503 no 1895 0.444330930576188 2669 70588 SGTC_695 3505-6186 243 µM -0.140256445274644 0.442342607181512 no 1896 0.444228687861623 2768 1819379 SGTC_2522 biochanin a 4.94 µM -0.1404508740117 0.442267362049086 no 1897 0.444151882258423 2762 5280373 A possible chelator. SGTC_2166 5933061 31.504 µM -0.141284590129591 0.441944732365224 no 1898 0.443822561397184 3156 2877375 SGTC_722 3534-0461 190 µM -0.141811144669039 0.441740987240593 no 1899 0.443614590433768 2707 658262 SGTC_3160 9100216 49.47 µM -0.142177785203471 0.44159912837436 no 1900 0.443469789179046 2622 17191039 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.142763081520234 0.441372683751904 no 1901 0.443238647515654 2670 65057 A dermal irritant. YDR527W RBA50 SGTC_2398 5228213 48.84 µM -0.144998960464441 0.440507824160769 no 1902 0.442355846272941 2735 80771 YMR134W ERG29 SGTC_190 3970-0790 3.722 µM -0.14583914962147 0.440182903990188 no 1903 0.442024184683338 2631 2832352 SGTC_1171 0368-0077 21.4 µM -0.146294837757424 0.440006695903021 no 1904 0.441844320444405 2672 3239779 SGTC_2919 7978188 46.38 µM -0.146567173697505 0.439901393159037 no 1905 0.441736832701445 2742 2980291 SGTC_1415 3966-0071 78.1 µM -0.147779190162019 0.439432800620803 no 1906 0.441258516422415 2670 2893185 SGTC_3297 9117502 71.43 µM -0.14929655109258 0.438846274800388 no 1907 0.440659818302034 2646 7453720 SGTC_2894 9048625 32.47 µM -0.149614306630177 0.438723465460347 no 1908 0.440534460089721 2778 4092861 SGTC_1801 st050089 28.441 µM -0.149927452595252 0.438602443445489 no 1909 0.440410926237131 2663 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_342 k048-0088 23.3 µM -0.151552733926806 0.437974410871797 no 1910 0.439769857760994 2640 6820570 SGTC_1447 4239-0816 81.9 µM -0.152004640717616 0.437799815137306 no 1911 0.439591637712005 2678 1341554 SGTC_1381 2324-0066 62.1 µM -0.15287747531401 0.437462626814303 no 1912 0.439247449591498 2794 10885928 SGTC_514 4466-0038 2.65 nM -0.15412415031897 0.436981097478798 no 1913 0.438755923293384 2740 5722064 SGTC_2195 6536160 144.242 µM -0.154525911481003 0.436825936725256 no 1914 0.438597541086877 2672 3834386 SGTC_1316 1272-0050 65.9 µM -0.15469305087876 0.436761390104249 no 1915 0.438531654320927 2672 7340392 SGTC_1255 0566-0045 221 µM -0.159046715314916 0.435080671046279 no 1916 0.436816034364454 2804 2788469 SGTC_2305 7443522 69.23 µM -0.159366718316784 0.434957180730138 no 1917 0.436689979348037 2703 5415886 SGTC_2435 5706476 10.6 µM -0.159510810245134 0.434901577204516 no 1918 0.436633221008748 2800 5725375 SGTC_110 0850-0284 111.64 µM -0.160199215649596 0.434635946748603 no 1919 0.43636207361808 2665 3906265 SGTC_496 calpeptin 138 µM -0.163529570180884 0.433351303532211 no 1920 0.43505074643646 2781 73364 A calpain inhibitor. SGTC_1377 2944-0135 198 µM -0.164852871034563 0.432841051180956 no 1921 0.434529894110444 2776 1894137 SGTC_2101 5377231 179.231 µM -0.164945265059241 0.432805429086439 no 1922 0.434493531977708 2822 2844213 SGTC_959 1222-0044 107 µM -0.165006767195704 0.432781717521127 no 1923 0.434469327810012 2738 6083612 SGTC_2259 7964009 200 µM -0.165897674827256 0.432438263724145 no 1924 0.434118738679416 2881 313134 SGTC_814 3342-0569 96 µM -0.16665021232789 0.432148192752267 no 1925 0.43382264118835 2699 4346283 SGTC_1881 5652484 16 µM -0.168121195445816 0.431581297521376 no 1926 0.433243967560503 2792 2255129 SGTC_1349 flufenamic acid 69 µM -0.16936948234142 0.431100336591651 no 1927 0.432753013129064 2700 3371 A non-steroidal anti-inflammatory. SGTC_499 genistein 192 µM -0.169851222619028 0.430914750890507 no 1928 0.432563571159719 2767 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1520 flindersine 88 µM -0.16992412596467 0.430886666921944 no 1929 0.432534903630758 2983 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_788 1182-0090 188 µM -0.169965334402818 0.430870792681868 no 1930 0.43251869953709 2924 5715185 SGTC_954 1189-0853 2.85 µM -0.170650869814842 0.430606728372127 no 1931 0.43224914811456 2662 2828194 SGTC_822 1487-0950 154 µM -0.171322855203464 0.430347913564107 no 1932 0.431984955142179 2751 1958375 SGTC_2644 guaiazulene 100 µM -0.172160788033177 0.430025226116443 no 1933 0.43165556208065 2806 3515 A coloring agent. SGTC_1754 st042065 16.137 µM -0.172379545248087 0.429940990523776 no 1934 0.431569575996854 2756 1126236 YIL048W NEO1 SGTC_3312 9133330 71.43 µM -0.172857844659693 0.429756825611706 no 1935 0.431381583928726 2868 17617324 SGTC_1127 asiatic acid 681.4 nM -0.174352188173303 0.429181540649537 no 1936 0.430794343518319 2708 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1282 0886-0010 32.4 µM -0.174591538987616 0.429089410500227 no 1937 0.430700298689877 2835 2836211 YNL267W PIK1 SGTC_2879 9041815 71.43 µM -0.174706964802349 0.429044982545403 no 1938 0.430654947413891 2712 4942971 SGTC_2134 5324836 1.464 µM -0.175922579737099 0.428577141163511 no 1939 0.430177382966437 2766 699272 SGTC_2229 7354935 190 µM -0.17782163276377 0.427846472968534 no 1940 0.429431528807164 2767 318112 SGTC_2328 6201408 200 µM -0.179586367190838 0.427167706057457 no 1941 0.42873865403898 2825 2890418 SGTC_3042 9091578 49.47 µM -0.181626760955618 0.426383181566571 no 1942 0.427937822970816 2709 25236497 SGTC_2584 androsterone 48.74 µM -0.182670128156277 0.42598212274303 no 1943 0.427528427811197 2822 2754130 A steroid. SGTC_1261 0712-0010 12.7 µM -0.183935029829709 0.425496011205895 no 1944 0.427032211891354 2847 2840123 SGTC_1749 st037932 54.2 µM -0.187407694317709 0.424162023552402 no 1945 0.425670495144483 2870 594497 SGTC_456 gingerol 170 µM -0.187418719301965 0.424157789795133 no 1946 0.425666173380687 2910 442793 A herb. SGTC_3211 9128781 49.47 µM -0.188222525070921 0.423849140084607 no 1947 0.425351107800932 2878 17194361 SGTC_2397 5161689 200 µM -0.188360494970682 0.42379616634375 no 1948 0.425297032898726 2920 2259942 SGTC_300 r073-0011 5.04 µM -0.188433631655305 0.423768085967216 no 1949 0.425268368817253 2760 2735780 SGTC_927 2425-1185 123 µM -0.188721400817443 0.423657602541156 no 1950 0.425155588778494 2712 730375 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.188869899016728 0.423600591865221 no 1951 0.425097393024343 2878 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3197 9113331 49.47 µM -0.189423621352284 0.423388023701892 no 1952 0.424880406214452 2934 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_538 2922-0838 53.3 µM -0.189547644563572 0.423340415553516 no 1953 0.424831808436947 2793 777039 SGTC_1608 st001473 40.5 µM -0.189672101282702 0.423292642121825 no 1954 0.424783041940338 2733 7292267 SGTC_2472 5377652 49.4 µM -0.189674125791738 0.423291865011639 no 1955 0.424782248676385 2783 1610903 SGTC_963 1269-2853 151 µM -0.190485771463413 0.422980337934349 no 1956 0.424464245895743 2769 3668223 SGTC_3121 9125696 49.47 µM -0.191428530556626 0.422618547166556 no 1957 0.424094934604593 2704 1235365 SGTC_1070 indatraline 8.81 µM -0.192164550432114 0.422336139451934 no 1958 0.423806656512531 2762 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2119 5528445 120.635 µM -0.194291320869527 0.421520331462063 no 1959 0.422973890546697 2876 791935 SGTC_1244 0416-0015 52.5 µM -0.194404523844729 0.421476917334993 no 1960 0.422929573989584 2779 96201 SGTC_2063 5246145 200 µM -0.194640368048829 0.421386472511461 no 1961 0.422837249132896 2867 711240 SGTC_677 0929-0063 136 µM -0.195201816964178 0.421171176952251 no 1962 0.422617478345192 2732 1539583 SGTC_2462 5162487 171.77 µM -0.195606424213163 0.421016039165885 no 1963 0.42245911581239 2722 2259986 SGTC_558 k064-0027 21.3 µM -0.197502607950522 0.420289152840435 no 1964 0.421717120392953 2874 5088526 SGTC_606 k015-0008 38.6 µM -0.199058772976316 0.419692812790829 no 1965 0.4211083851025 2893 1970475 SGTC_3061 glucosamine 200 µM -0.200857286806915 0.419003831688604 no 1966 0.420405083597144 2763 91431 and experimental redox chemotherapeutic SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.201295469481758 0.418836008644427 no 1967 0.420233772447183 2754 756377 SGTC_3339 9145883 14.936 µM -0.201722096500555 0.418672625581935 no 1968 0.420066993593744 2910 2030670 SGTC_2701 st077767 14.721 µM -0.202359606706029 0.418428507866633 no 1969 0.419817802142086 2794 5721188 SGTC_341 1486-1430 230 µM -0.204741668385393 0.417516638909317 no 1970 0.418886981644496 2751 2054753 YPL210C SRP72 SGTC_313 3474-0040 5.03 µM -0.205121945888727 0.417371107082204 no 1971 0.418738425316954 2765 1043375 YIL048W NEO1 SGTC_2189 6047310 154.431 µM -0.20741372203042 0.416494286936452 no 1972 0.417843383489968 2750 711535 SGTC_1190 1486-1332 13 µM -0.20747847765051 0.416469517828375 no 1973 0.417818099661053 2752 4150046 SGTC_1578 josamycin 24.2 µM -0.209417910136608 0.415727836554887 no 1974 0.417061006230136 2794 5282165 A P450 substrate. SGTC_266 formosanin C 406 nM -0.210267462012148 0.415403043753185 no 1975 0.416729464572161 2908 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_132 0417-1715 25.805 µM -0.211540388135268 0.41491649867067 no 1976 0.41623281001289 2848 6769098 SGTC_168 3970-0862 530.542 µM -0.212086055129366 0.414707970630564 no 1977 0.416019949320952 2860 3135186 SGTC_855 0428-0020 25 µM -0.214016589656789 0.413970405218924 no 1978 0.415267060110325 2798 6812414 SGTC_1247 0448-0043 5.84 µM -0.214265257256739 0.413875423156426 no 1979 0.415170104779889 2916 3089013 YGL099W LSG1 SGTC_1558 st069300 45.6 µM -0.214589868538779 0.413751440925783 no 1980 0.415043546832682 2853 24208000 SGTC_2806 7952793 58.44 µM -0.215946400388726 0.413233419494951 no 1981 0.41451476400169 2932 2972490 SGTC_1184 1269-1718 139 µM -0.216054187980576 0.413192264904335 no 1982 0.414472754494632 2935 5403821 SGTC_527 4476-4215 268 µM -0.216211560843717 0.413132179777712 no 1983 0.414411421210285 2810 4418754 SGTC_2897 9048598 12.99 µM -0.216392460094686 0.413063114764937 no 1984 0.414340921511487 2806 6467404 SGTC_2114 5491910 81.25 µM -0.218455031116915 0.412275842347274 no 1985 0.413537296057025 2914 2849228 SGTC_419 nsc-638432 893 µM -0.2186201480119 0.412212833317356 no 1986 0.413472978296651 2882 368090 SGTC_2576 guaiol 23.12 µM -0.218644779483539 0.412203434078622 no 1987 0.413463383831841 2947 227829 SGTC_755 1995-0008 37.3 µM -0.219296947718226 0.411954588479295 no 1988 0.413209369703802 2794 689533 SGTC_3230 9131665 49.47 µM -0.220133907961052 0.41163528430747 no 1989 0.412883433856641 2785 15943720 SGTC_263 alizarin 107.927 µM -0.220609669508895 0.41145380516352 no 1990 0.412698185688789 2779 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_759 3486-0358 89.3 µM -0.222063962898351 0.410899182862709 no 1991 0.412132045456047 2949 875103 SGTC_861 0443-0273 110 µM -0.222210080007574 0.410843468165113 no 1992 0.412075173778663 2893 6149169 SGTC_2031 5180455 200 µM -0.222689075971636 0.410660838823199 no 1993 0.411888752002199 2795 29949 SGTC_1079 idarubicin 2.36 µM -0.22500923713754 0.40977649342243 no 1994 0.410986044158336 2825 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3158 9100007 49.47 µM -0.225491756781905 0.409592635217242 no 1995 0.410798368697669 2820 19297233 SGTC_2067 5224629 34.075 µM -0.22563417550949 0.409538372102152 no 1996 0.410742978998304 2952 2835000 SGTC_2047 4141938 200 µM -0.225776891665813 0.409483997401751 no 1997 0.410687475407995 2825 3807862 SGTC_3204 9114183 49.47 µM -0.225967656426621 0.409411318954591 no 1998 0.410613288078547 2762 17027248 SGTC_842 0271-0008 11.1 µM -0.226016719228212 0.409392627283135 no 1999 0.410594208351221 2910 1221709 SGTC_1766 st045414 44.774 µM -0.226312802140607 0.40927983164655 no 2000 0.410479071004115 2795 253960 SGTC_3243 9134147 49.47 µM -0.228128580392945 0.408588258033864 no 2001 0.409773140949923 2861 24282180 SGTC_657 3534-0529 86.7 µM -0.22907463035324 0.408228049562699 no 2002 0.409405455629698 2975 1049549 SGTC_899 1083-0020 478 µM -0.230584585697153 0.407653294896639 no 2003 0.408818771885566 2992 767123 SGTC_1556 plumbagin 1.48 µM -0.231188113271088 0.407423621572621 no 2004 0.408584332064407 2797 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1635 st007035 42.4 µM -0.231597148585408 0.40726798065625 no 2005 0.408425461202847 2818 3716403 SGTC_2565 isoliquiritigenin 100 µM -0.23175768269204 0.407206900258425 no 2006 0.40836311326014 2955 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1624 st003710 6.25 µM -0.231785475516512 0.407196325807721 no 2007 0.408352319369321 3002 24207033 SGTC_1851 st056236 18.9 µM -0.231883152986478 0.407159162593976 no 2008 0.408314384951573 2897 5393171 SGTC_3294 9122953 26.2835 µM -0.231956678569605 0.407131188966994 no 2009 0.408285830825165 2795 16459826 SGTC_367 0335-0881 7.1 µM -0.232440576661819 0.406947096372659 no 2010 0.408097918088668 2972 23828853 SGTC_2676 harmalol 100 µM -0.233532689471522 0.406531692190444 no 2011 0.407673894328938 2886 5459187 A monoamine oxidase inhibitor SGTC_2515 chrysin 20.77 µM -0.235012727551195 0.405968901765912 no 2012 0.407099427345536 2923 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1981 st071826 47 µM -0.235046878129015 0.405955918160061 no 2013 0.407086174378315 2922 11838600 SGTC_460 trequinsin 123 µM -0.235181706500491 0.405904659175981 no 2014 0.407033851969398 2896 5537 A vasodilator. SGTC_1692 fluoroquinolonic acid 71 µM -0.235524129213307 0.405774484329913 no 2015 0.406900976556984 2943 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1211 1056-0033 32.3 µM -0.235576580341848 0.405754545516399 no 2016 0.406880624106267 2898 6741922 SGTC_2362 9071156 126 µM -0.235907234560997 0.405628855990944 no 2017 0.406752327154432 3003 653133 SGTC_1064 honokiol 6.76 µM -0.23595423359487 0.405610991330862 no 2018 0.406734091898549 2901 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2247 cerulenin 830 nM -0.237599837647453 0.404985609979827 no 2019 0.406095738223726 3043 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_964 1287-0107 19.4 µM -0.237674452258191 0.404957259815323 no 2020 0.406066800035849 2970 51516812 YPR165W RHO1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.239201378764901 0.404377206821296 no 2021 0.405474716797538 2772 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_265 mycophenolic acid 32.932 µM -0.239292654632222 0.40434253934002 no 2022 0.405439330370531 3064 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.23988257929041 0.404118498219385 no 2023 0.40521064316142 2814 442882 SGTC_1138 3761-0006 1.03 µM -0.239926052556176 0.404101989220002 no 2024 0.405193791814401 2806 12061087 SGTC_3037 9091026 49.47 µM -0.241598911857773 0.403466849875006 no 2025 0.404545482662714 2920 25236398 YIL048W NEO1 SGTC_857 0438-0306 1.35 µM -0.242785821777546 0.403016366593363 no 2026 0.404085659795978 2934 4686136 SGTC_305 1682-2595 20.8 µM -0.243168264444965 0.402871240565021 no 2027 0.403937525200076 2900 226033 SGTC_1560 lithocholic acid 53.1 µM -0.243218562550421 0.402852154871149 no 2028 0.403918043854705 2840 9903 A bile acid which acts as a detergent. SGTC_2603 homopterocarpin 100 µM -0.243486419276233 0.402750520122319 no 2029 0.403814302224935 2970 101795 A weak amylase inhibitor. SGTC_1207 2099-0101 141 µM -0.244470120376881 0.402377323973321 no 2030 0.403433370247525 2936 5837381 SGTC_1819 st053448 58.6 µM -0.244807156542294 0.402249479765116 no 2031 0.403302876192417 2863 2857616 SGTC_1134 3477-0009 42.5 µM -0.245931856657994 0.401822935419842 no 2032 0.402867491480628 3112 3973534 SGTC_846 0335-0850 148 µM -0.24666292869215 0.401545737832224 no 2033 0.402584549392846 2866 6819598 SGTC_2091 4-phenylthiadiazole 200 µM -0.249360321231002 0.40052340813153 no 2034 0.401541037463766 2863 270010 SGTC_2243 6634756 200 µM -0.250177108014083 0.400213974535352 no 2035 0.401225193811225 3113 885676 SGTC_3308 9128332 17.569 µM -0.254745397603692 0.398484471969671 no 2036 0.399459875225016 3017 17332805 YDL196W YDL196W SGTC_181 1447-1644 8.07 µM -0.255399923281595 0.398236838337235 no 2037 0.399207115019122 2953 534600 SGTC_1898 st060199 18.6 µM -0.256338398377422 0.397881846638796 no 2038 0.398844774931889 2851 688866 SGTC_1938 st074717 56.4 µM -0.256462659273979 0.397834849498848 no 2039 0.398796805008887 2811 17250979 SGTC_470 aa-861 153 µM -0.257261562908404 0.3975327288491 no 2040 0.398488431203587 2880 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1704 st028805 70.8 µM -0.25728957034664 0.397522138416002 no 2041 0.398477621586225 2906 2876101 SGTC_52 0329-0193 875 nM -0.258379433154311 0.397110088084408 no 2042 0.398057043900584 3077 3739292 SGTC_489 paxilline 115 µM -0.258416496665808 0.397096077298215 no 2043 0.398042743183515 2927 105008 A toxic potassium channel blocker. SGTC_1961 st076550 68.7 µM -0.259019429750802 0.396868174586991 no 2044 0.397810124588555 2977 1579337 SGTC_764 1951-2361 146 µM -0.259384744608319 0.396730106332469 no 2045 0.397669199536171 2877 5438930 SGTC_2339 9000433 200 µM -0.260363415660638 0.3963602881359 no 2046 0.397291730046587 2917 2988954 SGTC_2316 5844804 197.44 µM -0.261118403520142 0.396075058566455 no 2047 0.397000599959285 2998 776813 SGTC_1119 parthenolide 318.541 nM -0.261428829728265 0.395957797666528 no 2048 0.396880913470588 3077 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3153 9100258 49.47 µM -0.262131764562456 0.395692304732009 no 2049 0.39660992909179 2893 25236848 SGTC_3144 9087057 49.47 µM -0.262828953873972 0.395429029634192 no 2050 0.396341208953107 2917 17249618 SGTC_32 0928-0142 34.1 µM -0.26305900463206 0.395342167516494 no 2051 0.396252550474568 2920 2244242 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.263411110810764 0.395209230021156 no 2052 0.39611686386458 2988 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2271 7849410 118.62 µM -0.264320551447369 0.394865927668451 no 2053 0.395766462738842 2880 972430 SGTC_2319 6033012 152.6 µM -0.264369571699706 0.394847425458096 no 2054 0.395747577967718 2882 847246 SGTC_2024 5144227 134 µM -0.264647062753962 0.394742693670728 no 2055 0.395640680745308 3028 3475211 SGTC_2833 9001315 45.46 µM -0.265437276118606 0.394444489866874 no 2056 0.395336311752454 2864 2989378 SGTC_362 0310-0100 9.03 µM -0.265778851087542 0.394315608430005 no 2057 0.395204765986146 3002 790235 SGTC_1367 1812-0510 76.9 µM -0.267068766120866 0.393829008300782 no 2058 0.394708107713687 2920 1142582 YDR527W RBA50 SGTC_779 1360-0071 233 µM -0.267697905865988 0.393591735320242 no 2059 0.394465930939914 3073 7566 SGTC_84 0443-0269 128.823 µM -0.268672473406809 0.393224266156281 no 2060 0.394090868091829 2886 6150058 SGTC_859 0439-0102 54.6 µM -0.270243611020817 0.392632055444834 no 2061 0.393486421821054 3012 610143 SGTC_2585 alliin 100 µM -0.27027393349989 0.392620628397747 no 2062 0.393474758710859 3083 87310 A garlic compound which reacts with lipids. SGTC_2704 st078022 71.1 µM -0.270597964990148 0.392498522689404 no 2063 0.393350130578201 3041 54697681 SGTC_1262 0737-0114 49.6 µM -0.271230302946921 0.39226026746199 no 2064 0.393106953909635 3034 765919 SGTC_3010 9080089 71.4286 µM -0.27137273304404 0.392206607558818 no 2065 0.393052185665358 3001 17027233 SGTC_2653 dihydrofissinolide 100 µM -0.272656170986825 0.391723170613001 no 2066 0.392558764489536 2936 6857746 SGTC_2246 7293507 91.5585 µM -0.272738555058879 0.391692144424941 no 2067 0.392527097599441 3049 887656 SGTC_2681 menadione 3.18 µM -0.274285523242412 0.391109677820784 no 2068 0.391932604421626 2973 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_187 1488-2104 32.728 µM -0.274410223649249 0.391062736067149 no 2069 0.391884693561506 2947 2852859 SGTC_231 b-estradiol 524 µM -0.274928046043117 0.390867825931555 no 2070 0.391685759741996 2895 450 A steroid. SGTC_327 1273-0057 3.96 µM -0.275091372201017 0.390806355086503 no 2071 0.391623019976443 2939 3108138 SGTC_2742 clothiapine 36.27 µM -0.275127586222299 0.390792725633822 no 2072 0.391609109180488 2950 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1734 st037168 69.4 µM -0.275795765654495 0.39054127475267 no 2073 0.391352468075392 2973 708907 SGTC_3069 9117009 49.47 µM -0.279417728613756 0.389179048051695 no 2074 0.389962133608175 2957 41904981 SGTC_1341 1486-1360 280 µM -0.279460494991078 0.389162971638431 no 2075 0.389945725582666 2872 3976547 SGTC_2666 tannic acid 100 µM -0.279594031665795 0.389112774762454 no 2076 0.389894493298793 2982 16134267 A thiamine antagonist. SGTC_698 k064-0052 127 µM -0.279942160311829 0.388981920760814 no 2077 0.389760940292176 2892 5088751 SGTC_1529 apigenin 74 µM -0.280774375571594 0.388669160165456 no 2078 0.389441729334342 3131 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3052 9092717 49.47 µM -0.281457087361392 0.388412639371521 no 2079 0.389179918767399 3073 25237534 SGTC_2025 5147754 141 µM -0.283806862357503 0.387530112134917 no 2080 0.388279197640391 2996 315777 YLR208W SEC13 SGTC_843 0310-0051 143 µM -0.284743862531985 0.387178355836467 no 2081 0.387920191798592 2950 2065037 SGTC_1828 st055811 49 µM -0.285635790830904 0.386843605869725 no 2082 0.38757854393613 3061 5877589 SGTC_1274 0865-0114 173 µM -0.285641489472222 0.38684146738069 no 2083 0.387576361384791 2946 870624 SGTC_680 0417-1641 114 µM -0.287880094100125 0.386001668340967 no 2084 0.386719262397732 2886 2835990 SGTC_2446 5162541 200 µM -0.288375994330195 0.38581570645687 no 2085 0.386529470664532 2882 1549321 SGTC_3325 9138760 55.175 µM -0.288599501738303 0.385731900070723 no 2086 0.386443938419998 2954 43844959 SGTC_3276 9139060 49.47 µM -0.289678132854939 0.385327531358798 no 2087 0.386031243418027 2888 4870619 SGTC_550 4123-0385 25.7 µM -0.290922765311752 0.384861085203855 no 2088 0.385555194897831 2921 5731123 SGTC_108 0509-0257 621.132 µM -0.291107813129548 0.384791749748636 no 2089 0.385484432285807 3006 536624 SGTC_1321 1326-2144 215 µM -0.291478318355624 0.38465293644445 no 2090 0.38534276189236 3041 3513030 SGTC_2158 5657123 3.6195 µM -0.292826139287618 0.384148087382263 no 2091 0.384827523661427 2896 2858827 SGTC_1572 epiandrosterone 68.9 µM -0.293343287733829 0.383954432823876 no 2092 0.384629884669135 2890 441302 A steroid. SGTC_1071 trifluoperazine 6.31 µM -0.293374257605722 0.383942836575938 no 2093 0.384618049841966 3069 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2409 alverine citrate 63.97 µM -0.29369410280019 0.383823080966579 no 2094 0.384495830487602 3159 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_552 k242-0005 476 µM -0.294387157359342 0.38356362735166 no 2095 0.384231039648621 3049 4088318 SGTC_2160 5660466 132.927 µM -0.294691195909658 0.383449823195557 no 2096 0.384114894661037 2974 2859134 SGTC_1146 3579-1023 7 µM -0.295158988019159 0.383274744361048 no 2097 0.383936214921229 3042 X1146 SGTC_2534 helenine 20.12 µM -0.295672816934991 0.383082462971652 no 2098 0.383739979210879 2876 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_448 monastrol 171 µM -0.295831965459314 0.383022913386911 no 2099 0.383679205056336 2975 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_744 1594-0068 283 µM -0.295884849744878 0.383003125959543 no 2100 0.383659010731758 2954 668392 SGTC_993 3909-8757 62.7 µM -0.29618200204854 0.382891947766425 no 2101 0.383545546416654 2961 4288324 YLR208W SEC13 SGTC_2186 6124449 200 µM -0.298846109452734 0.381895616011879 no 2102 0.382528733687843 3084 3834182 YLR033W RSC58 SGTC_2946 9065502 71.43 µM -0.299699170479156 0.381576750332639 no 2103 0.382203315700501 2969 16489101 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.300989911407166 0.381094437109318 no 2104 0.381711093777761 2982 1377 SGTC_1623 st003709 20.3 µM -0.301679874731213 0.380836693100606 no 2105 0.381448055771432 2922 16192618 SGTC_1995 st072814 61.1 µM -0.302145401131335 0.380662820038168 no 2106 0.381270611845866 2937 5769371 SGTC_1008 4106-0037 6 µM -0.302858921946389 0.380396368410253 no 2107 0.380998688753323 2886 2905394 SGTC_2288 7946289 167.31 µM -0.303158469603963 0.380284524580184 no 2108 0.380884548514528 3146 1246052 SGTC_2824 7998404 51.95 µM -0.304035900638689 0.379956970739894 no 2109 0.380550270116903 2919 837851 SGTC_1359 1582-0056 520 nM -0.304245879192092 0.379878596389975 no 2110 0.380470286964021 3049 3661189 SGTC_2960 9079389 5.97 µM -0.304339857276185 0.379843520732996 no 2111 0.380434491327583 3110 16457355 SGTC_626 0214-0009 33 µM -0.304677654409639 0.379717452094238 no 2112 0.380305835068483 3072 3437874 SGTC_2479 5617353 43.85 µM -0.304680264917089 0.379716477881379 no 2113 0.380304840860186 3112 2731746 SGTC_1679 SEC14.276 6.7 µM -0.304772779056784 0.37968195310824 no 2114 0.380269607483513 3071 1005053 YMR079W SEC14 SGTC_2850 9015429 58.44 µM -0.305336220731827 0.379471706552265 no 2115 0.380055046038526 2996 6457570 SGTC_1980 st071811 45.7 µM -0.307558714685883 0.378642737717843 no 2116 0.379209069605623 3089 4974850 SGTC_637 1181-0519 7.26 µM -0.307776521473403 0.378561527848989 no 2117 0.379126194049621 2956 6252091 YGR060W ERG25 SGTC_968 1309-0633 340 µM -0.309506275859591 0.377916774775103 no 2118 0.378468219467471 3056 3761976 SGTC_1626 st003712 1.76 µM -0.311606609494906 0.377134348127523 no 2119 0.377669755266564 3111 24207035 SGTC_1715 st032160 10.2275 µM -0.312271805123114 0.376886651142399 no 2120 0.377416982838335 3069 5289825 SGTC_3123 9126162 49.47 µM -0.313364469171897 0.376479888969747 no 2121 0.377001887633476 2926 25239884 SGTC_1115 galangin 695.678 nM -0.313535798064302 0.376416121394855 no 2122 0.37693681389733 3122 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_248 streptozotocin 5.23457 mM -0.314410356988157 0.376090668450031 no 2123 0.376604695486783 3059 5300 DNA alkylating agent. SGTC_2201 6605497 169.863 µM -0.315117258766169 0.375827670770869 no 2124 0.376336312491005 2987 670741 SGTC_3279 9140807 49.47 µM -0.315373618287334 0.375732308314192 no 2125 0.37623899755716 2948 45595718 SGTC_1285 0929-0069 65.5 µM -0.315821168842047 0.375565843438383 no 2126 0.376069124726084 2983 1206237 SGTC_34 0469-0683 81.75 µM -0.318812900945207 0.374453675378875 no 2127 0.374934197422152 3036 3690923 SGTC_2980 9014342 25.29 µM -0.318937457185677 0.374407394513242 no 2128 0.374886969838519 3126 2996599 SGTC_1269 0831-0796 3.05 µM -0.319361997336221 0.374249663420741 no 2129 0.374726012432633 3091 927758 SGTC_1357 1503-1303 39.5 µM -0.320937163198974 0.373664619878172 no 2130 0.374129005125819 2997 292895 SGTC_1320 1313-0481 95.3 µM -0.321873147792849 0.373317116934348 no 2131 0.373774398239335 3146 6813365 YLR208W SEC13 SGTC_3005 9076496 71.4286 µM -0.322365456300648 0.373134378905005 no 2132 0.37358792521188 3076 21368410 SGTC_2127 5253358 187.912 µM -0.324840172959609 0.372216231713655 no 2133 0.372651019139074 2900 20612 SGTC_2447 5741742 33.78 µM -0.326099332815011 0.37174934782679 no 2134 0.372174600899108 3070 1776504 SGTC_2622 2-methoxyxanthone 59.94 µM -0.326129636227634 0.371738113945249 no 2135 0.372163137646746 3025 71034 A hepatoprotective. SGTC_2889 9059656 51.95 µM -0.328962571393817 0.370688390437515 no 2136 0.371091989316771 3067 3949838 SGTC_1358 1509-0022 2.48 µM -0.329110348782849 0.370633658931042 no 2137 0.371036141190077 3054 3258434 SGTC_1631 benzylvanillin 81.9 µM -0.330258685544025 0.370208444992681 no 2138 0.370602253658264 3126 75506 SGTC_2600 tangeritin 87.95 µM -0.330318558167939 0.370186279295663 no 2139 0.370579635895725 2959 68077 A bioactive flavone. SGTC_1695 st026914 34.495 µM -0.330732132698151 0.370033179899481 no 2140 0.370423414266522 2957 3289191 SGTC_994 3910-0338 138 µM -0.33376349482515 0.368911642914835 no 2141 0.369279016092432 3175 3479481 SGTC_2352 9027995 87.8 µM -0.334485233971695 0.368644779410247 no 2142 0.369006715743036 3044 2997347 SGTC_793 0488-0545 106 µM -0.336272714423041 0.367984130289983 no 2143 0.368332611906848 2981 292548 SGTC_1220 1838-0075 193 µM -0.337123969040116 0.36766964539396 no 2144 0.368011724650634 3023 5529645 SGTC_2677 mitomycin C 100 µM -0.337234970022283 0.367628644064665 no 2145 0.367969888721515 3015 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1422 4031-0024 15.5 µM -0.340120825009269 0.366563203239963 no 2146 0.366882769792482 3060 782427 SGTC_39 0986-0283 58.349 µM -0.34074613441222 0.366332477809721 no 2147 0.366647352289259 3190 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1928 4'-methoxychalcone 40.3 µM -0.342021151746133 0.365862174184763 no 2148 0.366167487169554 3211 641818 SGTC_244 nsc-207895 1.295 µM -0.342523137216564 0.365677066782115 no 2149 0.36597861743864 2949 42640 SGTC_753 1322-0200 289 µM -0.34272540897913 0.365602487801833 no 2150 0.365902522791584 3134 5403907 SGTC_377 3970-0964 33.1 µM -0.343527027686866 0.365306975495355 no 2151 0.365601005697796 2997 16481235 SGTC_2635 hydroquinidine 100 µM -0.344633775514588 0.364899110447674 no 2152 0.365184855241246 2976 442912 An experimental heart treatment. SGTC_1122 capsaicin 818.572 nM -0.345063977297386 0.364740611245961 no 2153 0.365023137019769 3142 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_355 1311-2252 105 µM -0.346928566740146 0.364053908260244 no 2154 0.364322492398326 3031 5338538 SGTC_438 sphingosine 6.67 µM -0.347247778809173 0.363936390466363 no 2155 0.364202589523535 2996 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_381 3461-2219 42.7 µM -0.347377271287724 0.363888721510508 no 2156 0.364153953169829 3122 2883159 SGTC_2391 6285546 200 µM -0.347436138010038 0.363867052105131 no 2157 0.364131844016462 2982 846083 SGTC_1714 st033236 13.627 µM -0.347668564707191 0.363781497861128 no 2158 0.364044553655792 3209 2916566 SGTC_2484 5809818 12.04 µM -0.349865244121017 0.362973255217293 no 2159 0.363219915859483 3034 2870548 SGTC_1903 st060211 78.3 µM -0.351502611561713 0.362371201446219 no 2160 0.362605656792602 3184 688960 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.353427099390347 0.3616640096238 no 2161 0.361884136327301 3015 279621 SGTC_447 ml7 120 µM -0.353615298570403 0.361594877353776 no 2162 0.361813603818815 3107 4216 Selective myosin light chain kinase inhibitor. SGTC_277 nystatin 15.5 µM -0.353765036353467 0.361539876553418 no 2163 0.361757489066075 2977 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1089 terbinafine 2.25 µM -0.354506020114564 0.361267744890698 no 2164 0.361479846606078 3134 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2907 7721985 69.9 µM -0.35491668898315 0.361116953987987 no 2165 0.361326002682481 3109 3267881 SGTC_63 0099-0242 26.702 µM -0.35544969569916 0.360921274807185 no 2166 0.361126362246013 3162 3898502 YLR359W ADE13 SGTC_2251 lansoprazole 556 µM -0.356389931786549 0.360576180999645 no 2167 0.360774284162822 2997 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1228 0124-0032 52.5 µM -0.358183625612895 0.359918158597015 no 2168 0.360102950153577 3106 X1228 SGTC_1236 0330-0013 258 µM -0.358188097209199 0.359916518695105 no 2169 0.360101277086741 3050 4617066 SGTC_1143 3454-2408 5.08 µM -0.358559261421295 0.359780407863851 no 2170 0.359962413758458 3056 X1143 SGTC_152 4469-0003 551.229 µM -0.358966872025338 0.359630952144656 no 2171 0.359809936065668 3064 697280 SGTC_210 3551-0445 56.827 µM -0.359172612146035 0.359555523009071 no 2172 0.359732981918914 3164 2865180 YOR207C RET1 SGTC_2812 7970281 58.44 µM -0.361334848352404 0.358763128117033 no 2173 0.358924572878901 3177 2233435 SGTC_1044 1222-0021 1.78 µM -0.361430617553814 0.358728045594237 no 2174 0.358888781613819 3111 4306703 SGTC_704 1310-0270 142 µM -0.361452213115349 0.358720134794127 no 2175 0.358880711001725 3097 5718033 SGTC_2845 9003024 42.97 µM -0.362079456041813 0.358490392120574 no 2176 0.358646327633354 3261 2990173 SGTC_335 4077-0256 27.6 µM -0.36541086976926 0.357271042448731 no 2177 0.357402364260976 3106 3121989 SGTC_591 4299-0174 154 µM -0.365966210561213 0.357067920264259 no 2178 0.357195144605895 3099 5509088 SGTC_830 4076-0286 57.8 µM -0.369119086902078 0.355915489328416 no 2179 0.356019481340512 3062 6866659 SGTC_801 0866-0028 10.1 µM -0.3696796924914 0.355710715702048 no 2180 0.355810582292821 3013 6849771 SGTC_595 3909-8003 73.7 µM -0.369988725771098 0.355597852238043 no 2181 0.355695445403243 3166 699517 SGTC_443 clozapine 122 µM -0.370911824720284 0.35526079844823 no 2182 0.355351603775949 3121 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1222 0366-0074 1.18 µM -0.370962827553576 0.35524217893375 no 2183 0.355332609353084 3183 286520 SGTC_2717 st081029 62.2815 µM -0.371800828881819 0.354936300781257 no 2184 0.35502057325007 3162 5292846 SGTC_723 4182-0001 115 µM -0.373588872092043 0.354283961368944 no 2185 0.354355107116041 3081 744821 YLR208W SEC13 SGTC_742 0kpi-0133 140 µM -0.373848208423826 0.354189382030699 no 2186 0.35425862530651 3212 2728852 SGTC_1604 st002052 72.4 µM -0.374492524943648 0.353954440281674 no 2187 0.354018958460816 3184 6254834 YHR062C RPP1 SGTC_3026 9090633 49.47 µM -0.37468850953863 0.353882988038029 no 2188 0.353946069405367 3055 25236842 SGTC_3098 9119039 49.47 µM -0.374784991853504 0.353847814317173 no 2189 0.353910188424427 3068 17161528 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.374988787702302 0.353773522332435 no 2190 0.353834402686054 3174 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1588 farnesol 29.9 µM -0.375046637376913 0.353752434756728 no 2191 0.353812891132762 3061 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1946 st076057 65.1 µM -0.376706007346402 0.353147746390097 no 2192 0.353196048995232 3032 953009 SGTC_1444 4112-3581 28 µM -0.376844873651586 0.35309715912569 no 2193 0.353144445302376 3095 2877249 SGTC_2250 alverine citrate 130 µM -0.377684999685804 0.352791167072805 no 2194 0.35283230619461 3086 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_70 0141-0289 43.283 µM -0.379013156191408 0.352307618058503 no 2195 0.352339047108751 3114 352408 SGTC_929 2805-0021 398 µM -0.379124835770283 0.35226696914563 no 2196 0.352297582150847 3146 3098024 SGTC_2829 7992743 58.44 µM -0.380329368321716 0.351828653109739 no 2197 0.351850468897558 3212 16462845 SGTC_1213 1315-0166 115 µM -0.380597429750832 0.351731135287668 no 2198 0.351750994387344 3159 768401 SGTC_2310 7668677 200 µM -0.381502456993732 0.35140196834935 no 2199 0.351415224201969 3291 2197143 SGTC_1093 fluphenazine 7.97 µM -0.38183881881801 0.351279658769589 no 2200 0.351290461610471 3091 6602611 An atypical antipsychotic. SGTC_189 3970-0742 2.116 µM -0.382337169344245 0.351098474357435 no 2201 0.351105643983682 3183 2891807 SGTC_2044 5102272 200 µM -0.382407227818803 0.351073006035154 no 2202 0.35107966501116 3177 592666 SGTC_782 0083-0095 30.5 µM -0.382523298057318 0.351030812551539 no 2203 0.351036625561032 3034 3591729 An indicator and reagent. SGTC_101 0490-5701 117.494 µM -0.383636871146939 0.350626103408785 no 2204 0.350623804030057 3163 4661669 SGTC_643 k048-0106 28.4 µM -0.385757927181844 0.349855710905393 no 2205 0.349837978625667 3160 6763920 SGTC_1121 fusaric acid 630.51 nM -0.386342109957262 0.349643637209658 no 2206 0.349621658785984 3076 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_942 3253-1115 227 µM -0.386687434672841 0.349518297322489 no 2207 0.349493809795333 3273 46497897 SGTC_37 0566-0070 1.56 µM -0.386745843618277 0.349497098693178 no 2208 0.349472186836902 3151 1626686 SGTC_2587 piperic acid 92.2 µM -0.387295426613099 0.349297658983117 no 2209 0.349268755452729 3119 5370536 SGTC_2373 9071805 200 µM -0.38738660569053 0.349264574775129 no 2210 0.349235009165888 3248 10149009 SGTC_2835 9006588 71.43 µM -0.38908051261493 0.348650151413319 no 2211 0.348608294319671 3267 2345538 SGTC_2699 st077704 54.6 µM -0.392708572372328 0.347335498094236 no 2212 0.347267369239975 3146 645852 SGTC_1860 st056228 74.6 µM -0.395662596756905 0.346266440310051 no 2213 0.346176975935449 3219 688679 SGTC_1241 0364-0022 50.8 µM -0.39772310440939 0.345521469036659 no 2214 0.345417152280384 3127 4563895 SGTC_207 4185-0010 4.486 µM -0.398346265078032 0.345296284518185 no 2215 0.345187480780025 3202 3761753 SGTC_2388 9080168 200 µM -0.398790799935464 0.345135681443705 no 2216 0.34502367827023 3087 15943073 SGTC_1311 1190-0148 100 µM -0.399155400051773 0.345003978281663 no 2217 0.34488935184107 3239 1961333 SGTC_2763 lisinopril 49.32 µM -0.399587147173673 0.344848044133571 no 2218 0.344730312308465 3160 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.40001479650316 0.344693615961448 no 2219 0.344572809295507 3144 6708630 An antioxidant. SGTC_888 0916-0002 6.97 µM -0.401173260543776 0.34427541381216 no 2220 0.34414628303558 3267 2802138 YIL048W NEO1 SGTC_3224 9130643 49.47 µM -0.401560394695925 0.344135701916171 no 2221 0.344003791147015 3290 17644395 SGTC_1826 st055655 41.6 µM -0.40358242381902 0.34340632287044 no 2222 0.343259906292915 3180 676168 SGTC_987 1497-1013 404 µM -0.405063555023634 0.34287242417727 no 2223 0.342715397411873 3199 1676435 SGTC_2663 amphotericin b 100 µM -0.405277555632094 0.342795309959013 no 2224 0.342636751257407 3176 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3252 9135871 49.47 µM -0.406026337431992 0.34252554115827 no 2225 0.342361624393224 3247 17682838 SGTC_2399 5884133 200 µM -0.406335094745064 0.342414326401236 no 2226 0.342248201227905 3116 722445 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.406394788268958 0.342392826297655 no 2227 0.342226274227539 3273 688798 SGTC_3232 9132874 49.47 µM -0.406980997104307 0.342181715787587 no 2228 0.342010972584825 3144 3784940 SGTC_1854 st056233 32.9 µM -0.409623126932673 0.341230822397542 no 2229 0.341041214579281 3207 5393174 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.409649073501258 0.341221489302124 no 2230 0.34103169643436 3149 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_736 0958-0254 92.6 µM -0.410273827675559 0.340996791801254 no 2231 0.340802544441188 3237 6812352 SGTC_806 3966-4455 5.86 µM -0.410598395451061 0.340880080828848 no 2232 0.340683520228786 3128 714982 SGTC_1435 4092-0789 56.7 µM -0.411309118483804 0.340624565901499 no 2233 0.340422942092921 3213 2248285 SGTC_1602 st001878 87.6 µM -0.411843455009557 0.340432512548991 no 2234 0.340227084118647 3276 595405 YLR310C CDC25 SGTC_838 0109-0203 71.4 µM -0.412905102529399 0.340051053792404 no 2235 0.33983807125973 3145 759422 SGTC_974 1326-0144 138 µM -0.414550793985193 0.339460066816794 no 2236 0.339235387943475 3157 5411856 SGTC_2582 agaric acid 100 µM -0.414669917464699 0.339417303485342 no 2237 0.339191778610313 3229 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1907 st060210 83.7 µM -0.41621182659351 0.338863970738164 no 2238 0.338627503200597 3272 688793 SGTC_2121 5257820 149.641 µM -0.417314211423565 0.338468579565027 no 2239 0.338224297499099 3270 791256 SGTC_727 3032-0951 202 µM -0.418657303489798 0.337987094763983 no 2240 0.337733301929326 3166 3652836 SGTC_2657 nystatin 74.44 µM -0.420192759102344 0.337436974166457 no 2241 0.337172321993777 3198 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_627 1391-0720 175 µM -0.42254733373608 0.336594055788928 no 2242 0.33631277948057 3206 997839 SGTC_2921 7974240 10.71 µM -0.422817957398366 0.336497227227194 no 2243 0.336214042425178 3251 2979074 YDR527W RBA50 SGTC_766 1391-0721 126 µM -0.423462029414743 0.336266823266009 no 2244 0.335979098170441 3271 1020919 YIL115C NUP159 SGTC_1039 k821-0043 94 µM -0.424950186081699 0.335734700070789 no 2245 0.335436494330578 3270 15992768 SGTC_391 gliotoxin 8.33 µM -0.42524404896929 0.335629661810152 no 2246 0.335329388118968 3302 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_147 4466-0538 29.23 µM -0.425393545538511 0.335576230730194 no 2247 0.335274905220078 3351 6742687 YHR072W ERG7 SGTC_1395 3486-0190 4.35 µM -0.426082517861231 0.335330030366911 no 2248 0.335023859238781 3311 6748079 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.426435240024889 0.335204014455009 no 2249 0.334895363746801 3163 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2421 5690543 90.72 µM -0.4264873938436 0.335185383201454 no 2250 0.334876365926652 3247 3397993 SGTC_3229 9132204 49.47 µM -0.427615427000211 0.334782507748296 no 2251 0.33446556620698 3137 17682924 SGTC_1042 0350-0096 82 µM -0.43056882263919 0.333728608010573 no 2252 0.333390957376295 3140 3122515 SGTC_3187 9109394 49.47 µM -0.430824866618041 0.333637302021094 no 2253 0.333297858622298 3188 17098090 SGTC_1312 1218-2183 165 µM -0.431415094543002 0.333426862653893 no 2254 0.333083288196058 3255 6744073 SGTC_1730 st033808 45.1 µM -0.431919007304878 0.333247239494035 no 2255 0.332900139861047 3136 1045166 SGTC_1606 st000094 49.2 µM -0.431938416048494 0.333240321878787 no 2256 0.332893086502259 3293 1242210 SGTC_1643 st009866 20.2 µM -0.432303356454484 0.333110261307011 no 2257 0.332760474007654 3244 3156273 YOR207C RET1 SGTC_2782 7736369 71.43 µM -0.433789370510282 0.332580870341236 no 2258 0.332220700565678 3178 2950836 YOL077C BRX1 SGTC_1333 1482-0047 286 µM -0.433886847226131 0.332546156014306 no 2259 0.332185305683028 3293 3811116 SGTC_1849 st056239 19.2 µM -0.433909527754782 0.332538079016568 no 2260 0.33217707034479 3143 5393181 SGTC_250 brefeldin a 552.239 µM -0.43462427369852 0.332283583290695 no 2261 0.33191758642486 3164 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2540 epiandrosterone 100 µM -0.434864476774081 0.332198072831694 no 2262 0.331830400331125 3204 441302 A steroid. SGTC_1389 3405-0187 19 µM -0.435941678307227 0.331814704804469 no 2263 0.331439522408904 3201 799890 SGTC_1188 1403-0014 4.57 µM -0.437287506051691 0.33133598209596 no 2264 0.330951427544713 3191 9614867 SGTC_3090 9117696 49.47 µM -0.43763539076523 0.331212281234422 no 2265 0.330825305966869 3197 7923821 SGTC_1711 st032263 62.8 µM -0.438791916824687 0.330801176095292 no 2266 0.330406158908474 3202 3958979 SGTC_1225 1216-0074 20.6 µM -0.439732521356977 0.33046697399638 no 2267 0.330065422706554 3178 4241466 SGTC_1388 3346-4487 254 µM -0.440452754733165 0.330211162361396 no 2268 0.329804611714289 3261 3345614 SGTC_718 1130-0073 349 µM -0.44045462974334 0.330210496501009 no 2269 0.329803932843302 3338 6740020 SGTC_47 0149-0135 24.25 µM -0.441161266177144 0.329959591522571 no 2270 0.329548126183942 3164 5239155 SGTC_51 1013-0126 23.419 µM -0.441497683441379 0.329840166908171 no 2271 0.329426369110584 3423 1627850 SGTC_3102 9121669 49.47 µM -0.441626354275505 0.329794494690802 no 2272 0.329379804984049 3186 41905072 SGTC_638 3970-0837 4.09 µM -0.443156077411888 0.329251708044024 no 2273 0.328826423042029 3193 4118451 YLR208W SEC13 SGTC_2456 5770359 74.46 µM -0.443576921341154 0.329102444412793 no 2274 0.328674247218651 3320 3118787 SGTC_344 k064-0035 6.43 µM -0.44372536165725 0.32904980255552 no 2275 0.328620578448869 3161 5088750 SGTC_2320 7373003 200 µM -0.444498752986466 0.328775587213268 no 2276 0.328341015117527 3240 5415828 SGTC_68 0986-0284 82.829 µM -0.445164052101381 0.328539771012078 no 2277 0.328100601535171 3294 423278 YIL048W NEO1 SGTC_2457 5731572 11.68 µM -0.447686965431151 0.327646141873578 no 2278 0.327189565016332 3305 2865357 SGTC_911 3456-4043 236 µM -0.449837551785702 0.326885171328062 no 2279 0.326413789389645 3248 914281 SGTC_1452 4194-0072 190 µM -0.451108556046111 0.326435772990635 no 2280 0.325955655695473 3328 1343545 SGTC_1392 3455-1037 33.9 µM -0.452499943919795 0.32594409844223 no 2281 0.325454430816448 3333 981132 SGTC_1379 2144-0755 36.5 µM -0.452695601433656 0.325874983213219 no 2282 0.325383973657816 3365 5392327 SGTC_19 0279-0214 38.434 µM -0.452888115067989 0.325806984386692 no 2283 0.325314654715202 3230 3566274 YBR002C RER2 SGTC_1474 0330-0125 5.35 µM -0.452889549826109 0.325806477629435 no 2284 0.32531413812037 3304 X1474 SGTC_223 busulfan 5 mM -0.453183097896883 0.325702803080078 no 2285 0.325208451117908 3273 2478 A DNA alkylator. SGTC_693 4161-2696 114 µM -0.454577681121562 0.325210452025182 no 2286 0.324706547259413 3297 805759 SGTC_323 4013-0906 34.3 µM -0.455781467559275 0.324785706078396 no 2287 0.324273566007346 3274 2910086 SGTC_2489 cantharidin 73.42 µM -0.456651305178696 0.324478932847463 no 2288 0.323960848173039 3279 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1290 0986-0249 10.2 µM -0.457722511497831 0.324101304770968 no 2289 0.32357590636001 3241 53329 SGTC_2012 4023501 200 µM -0.458162900477426 0.323946108659248 no 2290 0.323417705723253 3241 3477460 SGTC_2171 5739187 198.077 µM -0.458586967346812 0.32379669348844 no 2291 0.323265398631304 3135 2262761 SGTC_1880 MG-132 525 µM -0.460414372339452 0.323153153021868 no 2292 0.322609410217503 3320 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1406 3909-7906 11.9 µM -0.463206520798574 0.32217088958392 no 2293 0.321608171327231 3267 X1406 SGTC_1540 guanosine 70.6 µM -0.463514126210187 0.322062751336112 no 2294 0.321497945867785 3286 6802 Guanosine is a purine nucleoside SGTC_3288 9119690 36.221 µM -0.463909443971989 0.321923800054558 no 2295 0.321356313172484 3234 17595618 YKL019W RAM2 SGTC_482 fipronil 114 µM -0.465457787091669 0.321379808704023 no 2296 0.320801829899534 3285 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_510 ag-490 170 µM -0.46694398920283 0.320858009957782 no 2297 0.320269975914769 3358 5328779 SGTC_2898 9056270 58.44 µM -0.467076150898249 0.320811625701416 no 2298 0.32022269823008 3284 19154699 SGTC_321 4534-3890 65.3 µM -0.467264539123307 0.320745512682347 no 2299 0.320155311894544 3297 699746 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.46758504389554 0.320633047707667 no 2300 0.320040681193961 3132 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3046 9092212 49.47 µM -0.468409349671628 0.320343874838625 no 2301 0.31974594157908 3286 25236637 SGTC_2683 piperine 63.03 µM -0.472567633339565 0.318886782231268 no 2302 0.318260839359227 3245 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1913 st060213 96.1 µM -0.473847609967165 0.318438830674862 no 2303 0.317804290472651 3388 688959 SGTC_1557 sumaresinolic acid 42.3 µM -0.474414166494131 0.318240638374607 no 2304 0.317602296417879 3239 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1454 4239-0054 42.6 µM -0.476570313959493 0.317486852891763 no 2305 0.316834063313072 3406 1340767 SGTC_10 0279-0212 42.575 µM -0.477073165544492 0.317311165459307 no 2306 0.316655011174597 3277 39851 YBR002C RER2 SGTC_1650 st011916 45.8 µM -0.477136337044898 0.317289097365675 no 2307 0.316632520511462 3368 242528 SGTC_2511 berberine 10.47 µM -0.478535393911035 0.316800522731201 no 2308 0.316134594513141 3234 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3177 9107506 49.47 µM -0.478692672323248 0.316745618367063 no 2309 0.31607863976301 3304 8897194 SGTC_36 0335-0881 14.2 µM -0.47911772509479 0.316597256775903 no 2310 0.315927440332712 3277 23828853 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.479692814142834 0.316396573071616 no 2311 0.315722919131221 3352 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3175 9106517 49.47 µM -0.480300093633923 0.31618471483156 no 2312 0.315507011153295 3329 41468073 SGTC_2125 5246583 200 µM -0.481660744683089 0.315710251128927 no 2313 0.315023483308885 3411 835267 SGTC_2332 7982454 138.89 µM -0.482509728730227 0.315414361203693 no 2314 0.314721944492541 3335 2981748 SGTC_2680 butyl paraben 22.24 µM -0.482648858310636 0.315365882713722 no 2315 0.314672540768296 3323 7184 An antifungal and steroid mimetic. SGTC_721 1187-1332 279 µM -0.483156723748346 0.315188948409143 no 2316 0.314492230256203 3234 25730 SGTC_1027 k015-0025 8.67 µM -0.483290542158835 0.315142334713559 no 2317 0.314444727265947 3268 3598955 SGTC_592 k241-0073 46.5 µM -0.484575286761826 0.314694962495628 no 2318 0.313988823792387 3359 4230158 SGTC_180 1486-1293 102.781 µM -0.485061475181509 0.314525733421509 no 2319 0.313816369320321 3425 4140536 SGTC_2767 sibutramine 71.45 µM -0.485472088566127 0.314382840323515 no 2320 0.313670753521481 3428 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1055 3448-0672 86 µM -0.486407997840083 0.314057248664788 no 2321 0.313338960575271 3372 748378 SGTC_2126 5251174 33.877 µM -0.489132771656111 0.3131101568685 no 2322 0.312373850698026 3414 790722 SGTC_219 mitoxanthrone 164.414 µM -0.489252528222727 0.313068559437869 no 2323 0.312331462591654 3307 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3031 9088762 49.47 µM -0.490011130211896 0.31280511440393 no 2324 0.312063011421474 3219 205253 SGTC_1976 st070609 63.5 µM -0.490525889567857 0.312626404736151 no 2325 0.311880907162604 3286 682556 SGTC_532 1548-0774 215 µM -0.491319057662026 0.312351125775954 no 2326 0.31160040142463 3472 5932993 SGTC_1743 st037606 46.3785 µM -0.491964471827939 0.312127203924827 no 2327 0.31137222984923 3264 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1545 lovastatin 49.4 µM -0.492647544298303 0.311890292375202 no 2328 0.311130823934734 3332 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1896 st058441 89 µM -0.493285024525997 0.311669263870867 no 2329 0.310905604129754 3280 688759 SGTC_3343 9148379 18.9835 µM -0.493766365402115 0.311502417275969 no 2330 0.310735594793452 3406 1955036 SGTC_442 cape 100 µM -0.493896284821098 0.311457390099105 no 2331 0.31068971424796 3368 5281787 SGTC_1676 st018489 23.4 µM -0.497953770655944 0.310052577945356 no 2332 0.309258313280416 3287 3696235 SGTC_201 4262-0159 12.803 µM -0.501070867589064 0.30897523271313 no 2333 0.308160624365718 3290 1341029 SGTC_1674 st016616 23.6 µM -0.502279162460016 0.308558057202904 no 2334 0.307735582378243 3231 625830 SGTC_567 1080-0542 68.4 µM -0.502952865996037 0.308325561746894 no 2335 0.307498705576908 3369 5950415 SGTC_2002 4023503 131 µM -0.50383057581264 0.308022778915505 no 2336 0.307190219761058 3473 4736863 YCR052W RSC6 SGTC_2004 4023728 41.89 µM -0.504477556099706 0.307799674277704 no 2337 0.306962915013247 3410 360084 YDR527W RBA50 SGTC_1173 0443-0020 122 µM -0.504503724460545 0.307790651876268 no 2338 0.306953722796289 3289 5331295 SGTC_284 0988-0104 32.6 µM -0.504990470210347 0.307622851491312 no 2339 0.30678276468629 3341 4666532 SGTC_2628 lathosterol 100 µM -0.505161952711065 0.307563744319398 no 2340 0.306722545458431 3421 6710616 SGTC_1804 st050076 49.1 µM -0.506685136851382 0.30703894742939 no 2341 0.306187880486426 3377 3895976 SGTC_2869 9037858 32.47 µM -0.50692398994193 0.306956688944486 no 2342 0.306104076153532 3321 27187042 SGTC_521 r062-0005 13.8 µM -0.507046420816947 0.306914528809148 no 2343 0.306061123816825 3334 2832033 SGTC_2476 5806916 10.51 µM -0.507066237574681 0.306907704976565 no 2344 0.30605417176852 3263 2870194 SGTC_1832 st054113 55 µM -0.507772848265787 0.30666442974367 no 2345 0.305806326652165 3379 1251267 SGTC_2957 9076800 11.52 µM -0.508136554997067 0.306539244275762 no 2346 0.305678790441071 3290 16459615 SGTC_3195 9113082 49.47 µM -0.508549810973598 0.306397031675105 no 2347 0.305533908057636 3371 17018038 SGTC_593 1203-0218 61.7 µM -0.510005876150321 0.30589619257123 no 2348 0.305023672532869 3411 3666956 SGTC_600 1495-0418 41.6 µM -0.510142861025989 0.305849092880288 no 2349 0.304975689663521 3311 5377768 SGTC_1518 st038567 90.8 µM -0.510338891594706 0.305781697015943 no 2350 0.304907030184541 3380 77966 SGTC_1672 st016598 6.51 µM -0.510880070988032 0.305595672157458 no 2351 0.30471751839126 3308 4665860 YNL267W PIK1 SGTC_3081 9117243 49.47 µM -0.511010994469394 0.305550676090178 no 2352 0.304671679089583 3428 45595589 SGTC_3228 9131799 49.47 µM -0.511813323081568 0.305274994206817 no 2353 0.304390832517407 3330 17015818 SGTC_781 4335-2806 94.4 µM -0.512187655932063 0.305146410378934 no 2354 0.304259840735452 3417 845254 SGTC_1563 conessine 56.1 µM -0.512471099560082 0.30504906311599 no 2355 0.304160670886199 3397 441082 An anti-amoebic, histamine inhibitor. SGTC_1139 k015-0024 46.9 µM -0.516005850614026 0.303836231278218 no 2356 0.302925161488406 3394 2766652 SGTC_547 1120-0019 610 nM -0.516126037363546 0.303795031042572 no 2357 0.302883191860307 3348 3676939 SGTC_2895 9054447 58.44 µM -0.516637527308531 0.303619719245555 no 2358 0.302704606925458 3329 2697450 SGTC_352 k048-0007 5.11 µM -0.516652445252176 0.303614606838587 no 2359 0.302699399085337 3385 6811911 SGTC_2182 6325192 200 µM -0.517817766515701 0.303215367903776 no 2360 0.302292710624991 3390 736248 SGTC_1326 1431-2094 10.8 µM -0.518227433212579 0.30307507192456 no 2361 0.302149798254403 3263 616278 SGTC_1057 3448-5381 134 µM -0.518761273671925 0.302892294528176 no 2362 0.301963613349947 3375 5497911 SGTC_2654 protoveratrine a 100 µM -0.518985689969387 0.302815473148724 no 2363 0.301885360173823 3331 5702278 A heart drug and vasodilator. SGTC_80 0159-0065 512.242 µM -0.520809635303904 0.302191430646976 no 2364 0.301249695122396 3386 1548079 SGTC_145 3737-0113 38.366 µM -0.521333113668863 0.302012435037914 no 2365 0.301067368542957 3435 6849351 SGTC_947 3447-0010 211 µM -0.521367927777303 0.302000532562372 no 2366 0.301055244615163 3399 748350 SGTC_2394 5221648 200 µM -0.523124201970183 0.301400359660656 no 2367 0.300443912234693 3409 788586 SGTC_526 4469-0568 170 µM -0.523280143879146 0.301347095476888 no 2368 0.300389658340693 3343 2901964 SGTC_85 0868-0259 160.055 µM -0.524416168872519 0.300959197896758 no 2369 0.29999455648959 3339 83173 SGTC_569 4130-2812 160 µM -0.524451890914076 0.300947004199195 no 2370 0.299982136417887 3349 743552 SGTC_3306 9127676 59.7925 µM -0.524882146265555 0.300800154295056 no 2371 0.299832560721641 3367 41905287 SGTC_1909 st060837 51.5 µM -0.525046356241053 0.300744116522874 no 2372 0.299775483011182 3310 678937 SGTC_2528 xanthyletin 44.79 µM -0.527407972349887 0.299938720559955 no 2373 0.298955154207427 3300 65188 An natural product with antifungal activity of unknown mechanism. SGTC_598 3937-0236 20.2 µM -0.527499704783325 0.299907456206605 no 2374 0.2989233106941 3396 1379313 SGTC_2224 6650123 117.647 µM -0.527747694315144 0.299822943514274 no 2375 0.298837232629222 3367 2908370 SGTC_3262 9137218 49.47 µM -0.529325917929877 0.299285351384572 no 2376 0.298289689620502 3316 17650664 SGTC_873 0591-4978 488 µM -0.529503184093656 0.299224996332604 no 2377 0.298228218103111 3508 3305145 SGTC_2248 tofa 1.1 µM -0.529786558857661 0.299128525215377 no 2378 0.29812996273412 3274 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1472 k841-0093 193 µM -0.533046339565452 0.298019793658102 no 2379 0.297000751514335 3463 X1472 SGTC_3286 9117135 37.221 µM -0.533847710252173 0.297747514859407 no 2380 0.296723450890192 3319 3438150 SGTC_1785 bathophenanthroline 24 µM -0.535954377287789 0.297032282141752 no 2381 0.295995040840224 3308 72812 An iron chelator. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.536366973040077 0.296892294184371 no 2382 0.295852476182881 3328 390807 SGTC_594 1487-1584 10.8 µM -0.53672142840826 0.296772056558438 no 2383 0.295730026026476 3316 5013332 SGTC_808 0711-0032 135 µM -0.536901621146591 0.296710940493844 no 2384 0.295667785570508 3409 4252555 SGTC_1640 st009078 66.4 µM -0.538146534040648 0.296288860278914 no 2385 0.295237944216811 3427 690618 SGTC_996 3970-0799 1.8 µM -0.538561740863728 0.296148148163896 no 2386 0.295094646322853 3423 6615648 YGL040C HEM2 SGTC_2934 9036370 36.88 µM -0.538607102029303 0.296132777284288 no 2387 0.295078993031071 3376 6462800 SGTC_3100 9120536 49.47 µM -0.539494636181675 0.295832105150458 no 2388 0.294772798529546 3359 16421196 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.539625586145428 0.295787754781931 no 2389 0.294727633902018 3519 16725076 SGTC_658 3253-0951 102 µM -0.540259544601676 0.295573087797548 no 2390 0.294509026837166 3395 1184878 SGTC_1275 0867-0008 21.1 µM -0.542453175700471 0.294830847688014 no 2391 0.29375317796135 3314 3422836 SGTC_1218 1348-1416 30.7 µM -0.542729038619323 0.294737567174144 no 2392 0.293658188782214 3403 6787668 SGTC_1958 st076513 41.9 µM -0.542981269900114 0.294652289393989 no 2393 0.293571349241754 3332 732122 YGL099W LSG1 SGTC_209 4077-0173 175.592 µM -0.544034943549609 0.294296172222005 no 2394 0.293208713467491 3382 15993494 SGTC_651 3253-0966 34.4 µM -0.545602398403775 0.293766777083739 no 2395 0.292669637677307 3369 781462 SGTC_2019 4016004 108 µM -0.545881074995767 0.293672702483782 no 2396 0.292573844028738 3371 45595336 SGTC_409 arachidonic acid 100 µM -0.546783836274127 0.293368047507556 no 2397 0.292263624556995 3378 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2187 6125751 200 µM -0.546799099085843 0.293362898023442 no 2398 0.292258381051432 3410 874498 SGTC_2797 7859098 81.82 µM -0.549463643521001 0.292464556278695 no 2399 0.291343654071577 3371 972681 SGTC_308 4092-1169 104 µM -0.549566905004499 0.292429767786674 no 2400 0.291308231742218 3404 2268590 YDL196W YDL196W SGTC_2244 6635614 200 µM -0.550500098924249 0.292115464767702 no 2401 0.290988204527079 3208 836499 SGTC_116 0155-0182 31.788 µM -0.551119232952622 0.291907025026805 no 2402 0.290775970920698 3372 771486 SGTC_1780 st038448 24.544 µM -0.55280272934665 0.291340604023087 no 2403 0.290199249687162 3484 728868 YDL195W SEC31 SGTC_395 anisomycin 6.25 µM -0.553041126685107 0.291260435490877 no 2404 0.290117624416228 3398 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1722 st034304 3.6505 µM -0.553848210890502 0.290989104753078 no 2405 0.289841365382431 3364 4036148 YLR033W RSC58 SGTC_3178 9107506 49.47 µM -0.556249369147668 0.290182567133425 no 2406 0.289020196962835 3474 8897194 SGTC_1774 st048371 48.465 µM -0.556427107088224 0.290122907463935 no 2407 0.288959456166524 3339 4242727 SGTC_1936 st074407 74.3 µM -0.556480694400863 0.290104921428456 no 2408 0.288941144226078 3369 809813 SGTC_1178 0988-0033 191 µM -0.560416990376534 0.288785175131322 no 2409 0.287597522644424 3466 5392207 SGTC_883 0850-0245 24.6 µM -0.562326878909338 0.288145855031943 no 2410 0.28694666412029 3503 6823229 YPR165W RHO1 SGTC_544 k015-0020 52.4 µM -0.56255188469365 0.288070580115088 no 2411 0.286870031828927 3445 3008304 SGTC_3019 9081971 49.47 µM -0.562785838424265 0.287992321536235 no 2412 0.286790362338705 3528 16451803 SGTC_2294 7971431 200 µM -0.563384409968399 0.287792142353019 no 2413 0.286586575388785 3417 5741572 SGTC_539 4859-0462 2.54 µM -0.567808584422592 0.286314615964249 no 2414 0.285082475091473 3479 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1658 st012944 20 µM -0.568016307207772 0.286245332103034 no 2415 0.285011947526936 3450 24207260 SGTC_2180 6301957 200 µM -0.568442452302985 0.286103220586484 no 2416 0.284867285664628 3458 845462 SGTC_1217 1183-1422 255 µM -0.56869088509713 0.286020388308915 no 2417 0.284782967290745 3482 2849664 SGTC_3056 9094900 49.47 µM -0.568974993354917 0.28592567511621 no 2418 0.284686555224426 3391 25236784 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.569444469266134 0.285769198576886 no 2419 0.28452727284608 3436 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2810 7959871 45.46 µM -0.570086111638606 0.285555404773196 no 2420 0.284309647212731 3428 2974535 SGTC_1442 4112-3290 3 µM -0.571723060034953 0.285010322357793 no 2421 0.283754804639298 3455 704353 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.574810332382806 0.283983653396214 no 2422 0.282709789039409 3554 688751 SGTC_2686 alizarin 95.37 µM -0.576345724036187 0.283473720335192 no 2423 0.282190761396253 3401 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_417 st075190 100 µM -0.576387805995611 0.283459750289472 no 2424 0.282176542365312 3527 222757 SGTC_2021 4019055 173 µM -0.576394442921892 0.283457547043781 no 2425 0.282174299852453 3534 44827708 YER133W GLC7 SGTC_649 1123-0311 367 µM -0.576970765218696 0.283266257920659 no 2426 0.281979602348581 3473 693629 YIL048W NEO1 SGTC_1153 4055-0057 267 µM -0.579001415359353 0.282592751676915 no 2427 0.28129410908003 3404 882706 SGTC_1046 2001-0062 216 µM -0.579769583023962 0.282338174138912 no 2428 0.281035006072594 3438 739778 SGTC_1488 4013-0813 75.9 µM -0.580050923678674 0.282244962978 no 2429 0.280940138709025 3420 2910057 SGTC_3223 9129970 49.47 µM -0.580563459025619 0.282075192622671 no 2430 0.28076735286711 3491 17248386 SGTC_2883 9059145 45.46 µM -0.581062599501019 0.281909906410921 no 2431 0.280599132110815 3418 16476510 SGTC_1125 tnp00248 1.32998 µM -0.581555891881205 0.281746602605469 no 2432 0.280432930212865 3513 24207736 SGTC_2414 st077232 92.9 µM -0.581949055938167 0.281616478816194 no 2433 0.28030049805945 3338 729801 SGTC_523 1934-0222 13.7 µM -0.582922704048191 0.281294359568759 no 2434 0.279972667916115 3446 1361595 SGTC_2088 5278280 127.392 µM -0.583277587842351 0.281176994969937 no 2435 0.27985322375768 3521 791502 SGTC_463 ikarugamyin 104 µM -0.583935814194501 0.280959373746361 no 2436 0.279631748265949 3502 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_142 0335-0849 62.6745 µM -0.584038862826672 0.280925311424626 no 2437 0.279597082872078 3533 3889043 YPR107C YTH1 SGTC_2552 juarezic acid 87.02 µM -0.584723318664066 0.280699117899866 no 2438 0.279366885990659 3540 1549512 SGTC_2301 7769476 200 µM -0.585424485038354 0.280467493393936 no 2439 0.279131164516129 3464 977820 SGTC_3332 9141069 11.198 µM -0.588528905297673 0.279443086962128 no 2440 0.278088669004559 3455 17332883 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.58928312399449 0.279194482146663 no 2441 0.277835681859081 3499 229346 A bile salt which induces apoptosis. SGTC_1464 k208-0027 110 µM -0.589568226583713 0.279100534922907 no 2442 0.27774007933436 3550 X1464 SGTC_1876 myriocin 605 nM -0.591267065145177 0.278541051229374 no 2443 0.277170746626196 3542 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1968 st069590 43.6 µM -0.591585937521434 0.278436096941665 no 2444 0.277063946430476 3477 6384066 SGTC_1962 st076595 64.5 µM -0.593505961308368 0.277804544150079 no 2445 0.276421297318967 3488 279619 SGTC_2278 7948257 134.34 µM -0.593733920872036 0.277729607961911 no 2446 0.276345045794442 3506 1247028 SGTC_320 4092-0846 5.34 µM -0.59374301018563 0.277726620274766 no 2447 0.276342005670828 3465 1359356 SGTC_1162 k048-0130 20.1 µM -0.594553808357048 0.277460171430528 no 2448 0.276070882169305 3468 6797406 SGTC_1156 4092-0367 4.88 µM -0.595271396778719 0.277224457952402 no 2449 0.275831036151152 3478 1357585 SGTC_2274 7947094 46.08 µM -0.595320705203145 0.277208264716262 no 2450 0.275814559114065 3530 2971028 SGTC_441 propafenone 146 µM -0.597258238122571 0.276572331747505 no 2451 0.275167491009694 3482 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3321 9137793 26.8275 µM -0.598480111914713 0.276171658939377 no 2452 0.274759812659447 3513 4904192 SGTC_2344 7990960 76.95 µM -0.598507351762562 0.276162729786197 no 2453 0.274750727475137 3466 140813 SGTC_465 cgp-37157 41 µM -0.599882911159621 0.275712009240547 no 2454 0.274292136002887 3433 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2695 st077686 51.995 µM -0.600424733037545 0.275534573327041 no 2455 0.274111604288956 3482 2876092 SGTC_3191 9110352 49.47 µM -0.601086519307455 0.27531792767248 no 2456 0.273891180844786 3504 17122424 SGTC_868 0527-0199 213 µM -0.602713669598741 0.274785612369034 no 2457 0.273349593144814 3417 2849450 SGTC_2818 7996756 12.99 µM -0.602760180303155 0.274770404051785 no 2458 0.27333412012183 3485 2241621 SGTC_516 3992-2719 87.3 µM -0.603098679977622 0.274659732131606 no 2459 0.273221522269109 3412 5350887 YDR037W KRS1 SGTC_1821 st053465 65.6 µM -0.604122358190587 0.27432517602917 no 2460 0.272881147892085 3483 675086 SGTC_590 k048-0076 22.4 µM -0.604509729873093 0.274198628620492 no 2461 0.272752401157816 3532 6832814 SGTC_2624 nerol 100 µM -0.605051953396406 0.274021542320406 no 2462 0.272572238545128 3488 637566 A natural product oil. SGTC_2161 5662504 8.5105 µM -0.606589777252748 0.273519607778603 no 2463 0.272061593071644 3487 2859334 SGTC_3291 9121177 71.43 µM -0.608091844675011 0.273029783600667 no 2464 0.271563280418906 3467 17015612 SGTC_113 0099-0221 2.5 µM -0.609817981169664 0.272467428003952 no 2465 0.27099119443837 3583 89219 SGTC_21 0849-0113 22.993 µM -0.610005111472617 0.27240649766004 no 2466 0.270929210790877 3503 1560156 SGTC_2747 doxorubicin 7.63 µM -0.610823200784127 0.272140204136363 no 2467 0.270658316075373 3440 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.611464598985032 0.271931515285361 no 2468 0.270446023901357 3482 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2749 bexarotene 57.39 µM -0.612907399246384 0.271462368971242 no 2469 0.269968785244798 3503 82146 An retinoic acid receptor inhibitor. SGTC_1587 estradiol valerate 56.1 µM -0.613285346418804 0.271339540936268 no 2470 0.269843840410754 3573 13791 A steroid. SGTC_2426 5582046 32.21 µM -0.613851038472158 0.271155749962092 no 2471 0.26965688346572 3562 2251934 SGTC_429 1112-0049 25.5 µM -0.614873473543338 0.270823722661946 no 2472 0.269319141113014 3443 2836170 SGTC_3021 9087658 49.47 µM -0.615899838189569 0.270490623494488 no 2473 0.268980314185167 3552 25237042 SGTC_1546 5-methoxyflavanone 78.7 µM -0.616268886934913 0.270370901469242 no 2474 0.268858534904798 3578 147795 SGTC_2929 9013348 24.6 µM -0.618685903652458 0.26958745951888 no 2475 0.268061649052622 3528 2995952 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.619482458001571 0.26932951706526 no 2476 0.267799287322475 3568 676296 Flavone; oxidizing agent. SGTC_763 3453-1109 128 µM -0.619690780056029 0.269262078057086 no 2477 0.267730693471318 3571 1560353 SGTC_2712 st079126 47.7 µM -0.61982162987481 0.269219723061234 no 2478 0.267687613299803 3518 3152970 SGTC_2977 9011197 71.43 µM -0.620403859969878 0.269031300560319 no 2479 0.26749596589089 3581 2704722 SGTC_734 2023-0417 80 µM -0.62041477452977 0.269027769000117 no 2480 0.267492373904813 3523 3935732 SGTC_3079 9117512 49.47 µM -0.620616411475526 0.268962530700682 no 2481 0.267426019480018 3584 7185044 SGTC_2359 9039622 200 µM -0.621201447400679 0.268773291159789 no 2482 0.267233543615918 3518 6463596 SGTC_1305 1181-0477 144 µM -0.622382841450745 0.268391353726445 no 2483 0.266845080154799 3568 6252086 SGTC_2459 5811157 9.22 µM -0.623055451905366 0.268174024902476 no 2484 0.266624041359553 3532 2870684 YBR192W RIM2 SGTC_2284 7945075 39.21 µM -0.623632318265998 0.267987702761788 no 2485 0.266434540551665 3580 1245402 SGTC_1077 5-fluorocytosine 377 nM -0.625443492236965 0.267403135350973 no 2486 0.265840012379723 3539 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_773 4358-1457 44.6 µM -0.626577104116078 0.267037582777605 no 2487 0.265468240234062 3589 1186886 SGTC_3226 9131256 49.47 µM -0.627306228494484 0.266802597552613 no 2488 0.265229260713693 3481 17178073 SGTC_3348 9149464 3.537 µM -0.627369676204252 0.266782154305028 no 2489 0.265208470110565 3568 1951442 SGTC_2475 5812728 15.03 µM -0.628655940580746 0.266367882674487 no 2490 0.264787164348635 3569 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1061 3448-9325 110 µM -0.630776673733947 0.265685562296671 no 2491 0.264093278700477 3555 723482 SGTC_1147 3809-1045 12.3 µM -0.630931388160323 0.26563581949796 no 2492 0.264042693752101 3516 325925 SGTC_3013 9080133 71.4286 µM -0.631236891249293 0.265537609959496 no 2493 0.263942821912652 3636 17050193 SGTC_1243 0416-0003 5.65 µM -0.633319074971541 0.264868744963024 no 2494 0.263262649630055 3526 2141977 SGTC_3209 9113616 49.47 µM -0.633505632380766 0.264808858496196 no 2495 0.263201751962341 3606 16649353 SGTC_2877 9040724 71.43 µM -0.633742825987854 0.264732727333289 no 2496 0.263124335585239 3579 6463895 SGTC_1229 0139-0193 12.2 µM -0.635769023350499 0.264082840123864 no 2497 0.262463490189699 3612 3090752 SGTC_1085 doxorubicin 7.67 µM -0.637604454025187 0.263494842311862 no 2498 0.261865597783647 3594 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2354 9060492 162 µM -0.639742592827384 0.262810712644217 no 2499 0.261169979942837 3585 6471895 SGTC_3053 9095903 49.47 µM -0.640554908513171 0.262551038350116 no 2500 0.260905951910849 3623 17174018 SGTC_1150 3909-7983 10.9 µM -0.644025774763548 0.261442982033009 no 2501 0.259779360151179 3562 23965914 SGTC_628 1636-0253 16 µM -0.644496199795706 0.26129298624531 no 2502 0.259626860552973 3560 4456143 SGTC_1763 st044482 94.5 µM -0.64537185746354 0.261013899155004 no 2503 0.259343118170676 3569 88505 SGTC_2990 9074105 71.4286 µM -0.646397692600849 0.260687142990609 no 2504 0.259010917173846 3563 6502001 SGTC_2836 9010338 19.48 µM -0.648952149038262 0.259874395475045 no 2505 0.258184652919574 3501 2994051 SGTC_2197 6588183 93.1375 µM -0.650865831162952 0.259266379733118 no 2506 0.257566549981459 3582 884136 SGTC_1742 st038235 28.8875 µM -0.652434713513368 0.258768462863354 no 2507 0.257060388305889 3575 564103 YBR002C RER2 SGTC_15 0266-0086 27.098 µM -0.653616011039044 0.258393880827355 no 2508 0.256679613140849 3674 1712902 YIL048W NEO1 SGTC_2795 7780010 54.55 µM -0.653719299710036 0.258361141998498 no 2509 0.25664633341215 3580 953673 SGTC_1309 pyrazolanthrone 13.4 µM -0.65564075105386 0.257752502501982 no 2510 0.25602764950046 3634 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_853 0419-0306 21 µM -0.655712069411666 0.257729926011224 no 2511 0.256004700842543 3535 762713 SGTC_3067 9117431 49.47 µM -0.656702710402483 0.257416435565714 no 2512 0.255686045663943 3590 17150885 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.656828988060653 0.257376488974344 no 2513 0.25564544136709 3604 97141 SGTC_2076 5212012 200 µM -0.658240152664209 0.256930301325835 no 2514 0.255191913749481 3515 604802 SGTC_3193 9111931 49.47 µM -0.659050867983558 0.256674148269058 no 2515 0.254931552141307 3637 17087244 SGTC_2591 skatole 100 µM -0.659199906711202 0.256627072568529 no 2516 0.254883703414124 3619 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2058 5236698 133 µM -0.659912403436125 0.256402083926912 no 2517 0.254655022050471 3607 766665 SGTC_1522 st012842 45.6 µM -0.66105913805269 0.256040189782933 no 2518 0.254287194421903 3551 3491067 YOR116C RPO31 SGTC_1648 st011736 69.8 µM -0.661128923647734 0.256018174984332 no 2519 0.254264818926125 3634 2855514 SGTC_1857 st056007 79.3 µM -0.661568356323029 0.255879572763285 no 2520 0.254123946462031 3630 619834 SGTC_1724 st037281 8.293 µM -0.662050397833693 0.255727576267423 no 2521 0.253969461637624 3632 574124 YDL195W SEC31 SGTC_3040 9091894 49.47 µM -0.663769752034908 0.25518581665044 no 2522 0.253418844042254 3544 25236966 SGTC_35 0133-0054 64.071 µM -0.66461263593455 0.254920447688788 no 2523 0.253149142565724 3562 99677 SGTC_283 0987-0079 11.7 µM -0.667364001964416 0.254055228751581 no 2524 0.252269826966922 3644 411556 SGTC_3184 9108758 49.47 µM -0.668490124498228 0.253701543115975 no 2525 0.251910391813269 3629 902885 SGTC_2790 5423970 71.43 µM -0.669260956734682 0.253459594025629 no 2526 0.251664513939041 3645 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2975 9084847 53.72 µM -0.670024269678949 0.253220124632163 no 2527 0.251421159510184 3618 27211724 SGTC_758 0868-0029 16 µM -0.671799585147342 0.252663626498423 no 2528 0.250855646443225 3635 762687 SGTC_860 0443-0016 25.1 µM -0.671959478205757 0.252613537360925 no 2529 0.250804746814948 3644 5337942 SGTC_1271 0832-2808 169 µM -0.672253642553321 0.252521399193074 no 2530 0.250711118161142 3646 3663794 SGTC_3284 9108171 64.8615 µM -0.67280917084786 0.252347444906842 no 2531 0.25053435128928 3585 8687505 SGTC_4 0960-0234 25.671 µM -0.673242897513942 0.252211674665185 no 2532 0.250396387124601 3626 6821112 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.673782379961857 0.25204285327205 no 2533 0.250224839302624 3644 91467 include heat shock SGTC_2642 cholecalciferol 100 µM -0.675018164830991 0.251656361298916 no 2534 0.249832112136431 3617 9821465 A vitamin D precursor, similar to steriods. SGTC_276 colchicine 750 µM -0.676405254699345 0.251222921807249 no 2535 0.24939169096476 3670 2833 A microtubule depolymerizer. SGTC_324 1315-0088 19.6 µM -0.679542353009625 0.250244095547204 no 2536 0.248397140786776 3596 6787421 SGTC_2851 9015922 71.43 µM -0.68040210918289 0.249976190984483 no 2537 0.248124942944747 3637 2996893 SGTC_2059 5238311 157 µM -0.68087460860324 0.249829022504219 no 2538 0.247975417931106 3648 703021 SGTC_2745 rifampicin 24.3 µM -0.682980324588687 0.249173718880498 no 2539 0.247309637683863 3569 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3299 9121982 43.1275 µM -0.683781044455982 0.248924773150979 no 2540 0.247056718999915 3672 17594604 YPL160W CDC60 SGTC_476 mead acid 10 µM -0.68533985714671 0.248440514483613 no 2541 0.24656474315363 3670 5312531 An omega 9 fatty acid. SGTC_1324 1418-0026 34.4 µM -0.687344721560062 0.247818424860677 no 2542 0.245932761589953 3689 1372513 SGTC_1007 4101-0031 70 µM -0.688088716150693 0.247587782424057 no 2543 0.24569845790425 3631 1146276 SGTC_2887 9044784 58.44 µM -0.68835608707852 0.247504923975708 no 2544 0.245614284974909 3665 6465546 SGTC_107 0358-0022 2.6945 µM -0.69016756384638 0.246943936445601 no 2545 0.245044409342396 3652 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3239 9133757 49.47 µM -0.690535512044981 0.246830071536774 no 2546 0.244928742847704 3658 17036923 SGTC_2922 7999257 32.47 µM -0.691047618891039 0.246671642217159 no 2547 0.244767808218202 3647 2988377 SGTC_757 1066-0008 322 µM -0.693710729820148 0.245848640403401 no 2548 0.243931817848896 3678 6842497 SGTC_709 3807-1509 243 µM -0.693805608898135 0.245819346400941 no 2549 0.243902062334123 3701 1886677 YPL242C IQG1 SGTC_2425 5628681 7.85 µM -0.69468441359184 0.24554810371716 no 2550 0.243626548989889 3685 5714958 SGTC_2953 9074162 66.49 µM -0.69498012856749 0.245456867585789 no 2551 0.243533877433282 3618 16451992 SGTC_2580 diallyl disulphide 81.36 µM -0.697644683935338 0.2446356017505 no 2552 0.242699714862634 3684 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1687 st020778 55.3625 µM -0.699401039117465 0.244095070457557 no 2553 0.242150719316708 3677 4259299 SGTC_469 w7 172 µM -0.700173135971262 0.243857655916398 no 2554 0.241909593111227 3710 45115570 A P450 inhibitor. SGTC_2800 7887935 81.82 µM -0.701279480012268 0.243517679965624 no 2555 0.241564308525554 3659 2961002 SGTC_2333 9017922 200 µM -0.703024332705603 0.242982013087402 no 2556 0.24102029279259 3696 3163164 SGTC_895 0964-0006 13.7 µM -0.703924124929292 0.242706027669311 no 2557 0.240740013290072 3654 6738897 SGTC_1387 3342-1166 1.8 µM -0.70400140849066 0.242682331072961 no 2558 0.240715948231155 3670 3418228 SGTC_1779 st039427 55 µM -0.704775037488281 0.242445190882559 no 2559 0.240475122757048 3719 1124498 SGTC_1391 3442-0225 151 µM -0.705560083430325 0.242204679441889 no 2560 0.240230877456429 3639 5227075 SGTC_2198 6589944 200 µM -0.706401089839476 0.241947167172939 no 2561 0.239969371662841 3656 5290268 SGTC_2272 7805186 180 µM -0.708237770059376 0.241385300908333 no 2562 0.239398807288569 3658 2956062 YPR165W RHO1 SGTC_2163 5671233 125 µM -0.708346326853731 0.241352114062024 no 2563 0.239365107345773 3721 701023 SGTC_1394 3474-0001 65.7 µM -0.708832890188915 0.241203397475385 no 2564 0.239214092382904 3661 5017666 YIL048W NEO1 SGTC_2327 6189656 200 µM -0.712560279241365 0.240065786459972 no 2565 0.238058949129568 3745 5349088 SGTC_3324 9138759 60.749 µM -0.71277462876819 0.240000455364284 no 2566 0.237992613841671 3721 45595710 SGTC_176 1486-1328 72.834 µM -0.713496788690411 0.239780421282594 no 2567 0.237769199786412 3726 22310231 SGTC_2162 5663267 200 µM -0.71620267766943 0.238956946731148 no 2568 0.236933104966766 3687 6456493 SGTC_703 3875-0075 71.8 µM -0.717720225024295 0.238495794070825 no 2569 0.236464905092226 3753 2850814 SGTC_1979 st071809 45.3 µM -0.718058072657554 0.238393195197344 no 2570 0.236360740313704 3775 4976333 SGTC_1708 st033234 31.827 µM -0.719265932557988 0.238026585389161 no 2571 0.235988541076153 3788 674664 SGTC_1294 1000-1494 117 µM -0.721987771175318 0.237201586539897 no 2572 0.235150998012403 3694 712797 YDL207W GLE1 SGTC_314 1671-0008 2.74 µM -0.722863098067061 0.236936606069025 no 2573 0.234881998489934 3646 3913060 SGTC_1133 3473-0247 50 µM -0.722886688130578 0.236929467096649 no 2574 0.234874751305807 3729 711311 SGTC_683 panaxydol 45 µM -0.723511379966523 0.236740461982532 no 2575 0.234682882563722 3687 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_58 0957-0393 9 µM -0.723590337692005 0.236716578645791 no 2576 0.234658637546212 3651 6997992 SGTC_1393 3470-5649 58.2 µM -0.724219734219135 0.236526244553206 no 2577 0.234465422523654 3673 4108395 SGTC_1253 0550-0034 176 µM -0.726026609556319 0.235980300514042 no 2578 0.233911229028794 3697 5969915 SGTC_3300 9124615 50.48 µM -0.726173237342347 0.235936027683899 no 2579 0.233866288131871 3731 24824903 SGTC_2086 5274770 176.623 µM -0.726676689896513 0.23578404994455 no 2580 0.233712018130394 3749 689278 SGTC_799 1310-0557 151 µM -0.727071864527861 0.235664795994901 no 2581 0.233590966623944 3748 5354492 SGTC_2441 5730946 39.09 µM -0.727405951151779 0.23556400285389 no 2582 0.233488654972383 3754 1774275 SGTC_543 3844-1095 191 µM -0.727479182801837 0.235541912217334 no 2583 0.233466231622355 3728 4230703 SGTC_1219 1469-0211 33.1 µM -0.728977667409392 0.2350901390649 no 2584 0.233007661729528 3686 6822282 SGTC_1603 st002045 67.8 µM -0.729634777339704 0.234892180237361 no 2585 0.232806729235409 3720 5887985 SGTC_1022 4477-0945 21.3 µM -0.729872976667347 0.234820443828896 no 2586 0.232733915912936 3698 4648966 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.730273145001069 0.234699955897135 no 2587 0.232611620024985 3741 165506 SGTC_2096 5468907 200 µM -0.732178746179214 0.23412666173036 no 2588 0.232029737534191 3758 759785 SGTC_29 0299-0004 12.984 µM -0.732643318650811 0.233987014213871 no 2589 0.231888001548808 3622 16871 A napthoquinone isolated from Swertia calycina. SGTC_345 1362-0200 395 µM -0.732929152623539 0.233901117280902 no 2590 0.23180082069338 3725 1419823 SGTC_3093 9117344 49.47 µM -0.733630100308488 0.233690547099198 no 2591 0.231587105296854 3761 24824913 SGTC_1221 2958-7315 257 µM -0.735076732359273 0.233256299926089 no 2592 0.231146381941407 3747 4562705 SGTC_707 0865-0008 204 µM -0.735493978830789 0.233131134961192 no 2593 0.23101935282892 3722 723043 SGTC_2840 9008771 71.43 µM -0.735940009983306 0.232997376456028 no 2594 0.230883603432393 3704 2992978 SGTC_2275 7947463 200 µM -0.736457669561362 0.232842191039383 no 2595 0.230726109814388 3678 1225414 SGTC_2386 9075165 157.42 µM -0.736951386825553 0.232694236634078 no 2596 0.230575956375848 3704 16452277 SGTC_3054 9094397 49.47 µM -0.73702831531996 0.232671187842869 no 2597 0.230552565154575 3743 2598354 SGTC_3272 9137413 49.47 µM -0.737923893422195 0.232402954233989 no 2598 0.230280349286726 3696 17614870 SGTC_2766 oltipraz 83.91 µM -0.73943539264171 0.231950637132403 no 2599 0.229821328767212 3715 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_938 3126-1755 342 µM -0.741856904963851 0.231227020889263 no 2600 0.229087019306693 3736 1777771 SGTC_336 4111-0029 111 µM -0.742002854032311 0.231183447465854 no 2601 0.22904280319644 3688 3131175 SGTC_3000 9075062 71.4286 µM -0.742779414991959 0.230951680497755 no 2602 0.228807620109919 3716 17057871 SGTC_863 0466-0191 129 µM -0.744786760068291 0.230353183738683 no 2603 0.228200320037871 3749 765160 YPR165W RHO1 SGTC_229 benomyl 22.8748 µM -0.746201790304249 0.22993180932342 no 2604 0.227772763406527 3763 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1429 4049-0205 9.46 µM -0.746772222576723 0.229762065394087 no 2605 0.227600532771218 3765 22774478 SGTC_3170 9103054 49.47 µM -0.74760338017179 0.229514862907616 no 2606 0.227349712640695 3736 16432970 SGTC_2956 9076196 2.52 µM -0.751559205640561 0.228340368029114 no 2607 0.226158091815382 3781 16423868 SGTC_2442 5158906 48.48 µM -0.751572159644701 0.228336527508377 no 2608 0.226154195462646 3765 1893835 SGTC_885 0865-0106 16.8 µM -0.754186618330501 0.227562152851755 no 2609 0.225368585838394 3701 2793380 SGTC_1508 1080-0625 72.9 µM -0.754548414726844 0.22745510923839 no 2610 0.225259992734872 3682 767111 SGTC_2805 7950783 58.44 µM -0.754851286264471 0.22736552135911 no 2611 0.225169108706491 3794 1178958 YDL195W SEC31 SGTC_878 0828-0289 13.7 µM -0.755300369676603 0.227232721340607 no 2612 0.225034388463549 3755 745350 YLR208W SEC13 SGTC_2748 diazoxide 86.69 µM -0.756247863726539 0.226952678038015 no 2613 0.224750300236028 3751 3019 A potassium channel activatior. SGTC_922 1866-0035 480 µM -0.756875002575235 0.226767426684631 no 2614 0.224562376386679 3741 3156169 SGTC_2053 5265679 138 µM -0.757639499737474 0.226541716321199 no 2615 0.224333413368548 3733 764595 SGTC_1661 st013063 9.66 µM -0.759889746580203 0.225878089396025 no 2616 0.223660245522945 3810 721395 SGTC_1208 2323-2347 50.3 µM -0.760739588952222 0.225627746153866 no 2617 0.223406311839357 3754 5412760 SGTC_926 2268-1401 59.4 µM -0.760997540341791 0.225551790912501 no 2618 0.22332926819016 3754 2931578 SGTC_979 1426-2828 121 µM -0.761369337491026 0.225442338609946 no 2619 0.223218248257542 3884 747872 SGTC_990 3985-0011 41.3 µM -0.762825535961318 0.225013942116802 no 2620 0.222783724896022 3778 5399565 YGL099W LSG1 SGTC_3162 9099653 49.47 µM -0.763912934135288 0.224694343439363 no 2621 0.222459564553671 3728 25237511 SGTC_3344 9148862 3.898 µM -0.764348219642463 0.224566480276549 no 2622 0.222329878592023 3777 4905352 SGTC_2464 5717415 7.67 µM -0.764662220242749 0.224474269645664 no 2623 0.222236354203035 3765 5285744 SGTC_858 0438-0351 2.77 µM -0.766947320763157 0.223803865673121 no 2624 0.221556418528553 3798 2799119 SGTC_2516 gossypol 71.55 µM -0.767186443584991 0.223733777533893 no 2625 0.221485335899932 3821 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_364 0083-0097 67.7 µM -0.767617901253505 0.223607346629134 no 2626 0.221357112017302 3864 5207356 SGTC_3176 9106582 49.47 µM -0.767887863517081 0.223528259715214 no 2627 0.221276904166046 3674 17018027 SGTC_2046 4110841 106 µM -0.768085696261672 0.223470313639555 no 2628 0.221218137101658 3796 44119630 YMR134W ERG29 SGTC_983 1491-0821 12.2 µM -0.770596483106823 0.22273563604256 no 2629 0.220473073213528 3774 46495113 SGTC_2972 9093619 59.92 µM -0.77184926051162 0.222369578087787 no 2630 0.220101856000698 3802 25236256 SGTC_886 0866-0150 153 µM -0.772403689544645 0.222207685125993 no 2631 0.219937684662137 3810 271463 SGTC_2090 5301565 104.445 µM -0.772865106174852 0.222073003028578 no 2632 0.219801108708761 3796 2056344 SGTC_1346 1488-2224 62.4 µM -0.776180823326675 0.221106555733489 no 2633 0.218821113594052 3758 3722427 SGTC_2334 9017922 200 µM -0.776360190819805 0.22105434337327 no 2634 0.218768171420562 3851 3163164 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.77680339741159 0.220925359944388 no 2635 0.218637386018136 3792 61125 An anti-inflammatory. SGTC_912 3474-0017 2.18 µM -0.777129698881236 0.220830426167795 no 2636 0.21854112680744 3827 3360550 SGTC_1702 st027038 51 µM -0.777707204040299 0.22066246474303 no 2637 0.218370822119852 3818 5521182 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.778389791892879 0.220464035494099 no 2638 0.218169627445784 3621 88881 An O-methylated flavonoid and antioxidant. SGTC_2336 9001819 198.65 µM -0.778683852218028 0.22037858327047 no 2639 0.218082985279331 3816 2989602 SGTC_2261 9010538 184.68 µM -0.778691504993917 0.220376359671723 no 2640 0.218080730724229 3766 6457250 SGTC_1380 2291-0730 164 µM -0.779589506140365 0.220115524809017 no 2641 0.217816267332844 3841 2999191 SGTC_828 2074-0507 139 µM -0.780122657579043 0.219960748593893 no 2642 0.217659340570151 3862 X828 SGTC_848 0368-0089 85.6 µM -0.780587703443302 0.219825794733983 no 2643 0.21752251315436 3799 762535 SGTC_11 0438-0307 1.3 µM -0.782361702472006 0.219311426212068 no 2644 0.217001017117235 3791 4011476 SGTC_2258 7960471 200 µM -0.782397939999714 0.21930092640596 no 2645 0.216990372039154 3810 2974708 SGTC_94 0334-0113 514.748 µM -0.783222576616826 0.21906206645085 no 2646 0.216748209698412 3813 6795178 SGTC_330 1488-0319 80.1 µM -0.783561441299732 0.21896395605563 no 2647 0.216648744202695 3852 6846614 SGTC_712 r015-0009 80.6 µM -0.784272556746663 0.218758151292217 no 2648 0.216440099395887 3838 6813872 YLR060W FRS1 SGTC_3198 9112019 49.47 µM -0.786605784229481 0.218083671511311 no 2649 0.215756336093587 3852 45595555 SGTC_1497 4476-2978 41.3 µM -0.787014427021737 0.217965666215579 no 2650 0.215636710381926 3841 1528379 SGTC_1847 st056231 15 µM -0.789559428164158 0.217231565921383 no 2651 0.214892555191484 3820 5393180 SGTC_2938 9059746 27.26 µM -0.791590125571633 0.216646841202473 no 2652 0.21429985320109 3830 6471769 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.792009053230281 0.216526327371123 no 2653 0.214177698727374 3623 4000243 SGTC_383 2324-0395 7.37 µM -0.792390992728146 0.216416487813784 no 2654 0.214066364889084 3854 3146421 SGTC_3292 9120825 59.784 µM -0.793755941345555 0.216024214540674 no 2655 0.213668763193262 3805 24824900 SGTC_211 3455-0679 143.504 µM -0.794618222785819 0.21577661547706 no 2656 0.213417807448249 3859 748649 SGTC_33 0986-0033 35.816 µM -0.795914739005143 0.215404638215234 no 2657 0.213040796899351 3736 2848082 SGTC_3124 9127567 49.47 µM -0.797356461672041 0.214991437641887 no 2658 0.212622018764191 3759 17592030 SGTC_1991 st073000 8.92 µM -0.7996566926796 0.214333140803315 no 2659 0.211954865470623 3909 4301969 YIL048W NEO1 SGTC_685 1278-0033 54.9 µM -0.802340265431295 0.21356662015575 no 2660 0.211178078316809 3860 3590572 SGTC_2645 abamectin 100 µM -0.803784417365028 0.213154782664769 no 2661 0.210760745341529 3792 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_739 1486-1183 203 µM -0.804636129183037 0.212912112190411 no 2662 0.21051484345967 3797 4346692 SGTC_390 dec-rvkr-cmk 16.7 µM -0.805503568452746 0.212665126440255 no 2663 0.210264573986934 3884 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_749 1000-0129 128 µM -0.805892808258778 0.212554352697442 no 2664 0.210152329175657 3880 708470 SGTC_2536 dehydroabietamide 32.04 µM -0.808525422024559 0.211806022536198 no 2665 0.20939408872896 3888 3983547 SGTC_2513 baicalein 25.65 µM -0.808830283921681 0.211719464124656 no 2666 0.209306387105717 3858 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_623 k072-0108 16.9 µM -0.809151353596854 0.211628326279339 no 2667 0.209214046262464 3843 5382803 SGTC_1877 wortmannin 25 µM -0.812802312989585 0.210593592607574 no 2668 0.208165704601661 3848 312145 A covalent inhibitor of PI 3-kinase. SGTC_3080 9117754 49.47 µM -0.815244839172367 0.209903006511461 no 2669 0.207466088124414 3870 9550191 SGTC_1100 amiodarone 5.07 µM -0.815455977605094 0.209843372984948 no 2670 0.207405676755181 3935 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1507 4075-3230 155 µM -0.81671038514502 0.209489285967087 no 2671 0.207046977529521 3758 659771 SGTC_2120 5538279 151.968 µM -0.817149203936303 0.209365501734638 no 2672 0.206921583518098 3838 2058197 SGTC_1707 st032323 6.317 µM -0.817554029753299 0.209251344592322 no 2673 0.206805942985262 3746 3132057 YMR211W DML1 SGTC_588 3970-1144 52.9 µM -0.81804912898285 0.209111780998605 no 2674 0.206664567416426 3783 1888707 SGTC_792 4534-1957 155 µM -0.818633064001935 0.208947245936003 no 2675 0.206497898368877 3826 1717904 SGTC_1361 1608-0041 5.61 µM -0.820097094645003 0.208535062220269 no 2676 0.206080379183516 3819 X1361 SGTC_568 1193-0097 7.48 µM -0.820384316069933 0.208454254086558 no 2677 0.205998526794425 3736 3646150 SGTC_2371 9071574 200 µM -0.82071995048802 0.208359848630825 no 2678 0.205902902100653 3846 45596039 SGTC_1654 st012436 41.8 µM -0.820760788800371 0.208348363569736 no 2679 0.205891268764783 3799 4323132 SGTC_1621 st003705 32.4 µM -0.823161899536399 0.207673749834336 no 2680 0.205207966115361 3900 24207032 SGTC_2097 5376186 200 µM -0.824998985905048 0.207158476319512 no 2681 0.204686083215012 3806 742755 SGTC_3345 9148410 3.559 µM -0.826642973986573 0.206698005606849 no 2682 0.204219726132846 3837 4903596 SGTC_1012 4112-3522 18 µM -0.827490912912507 0.206460740356076 no 2683 0.203979435249173 3847 3112398 SGTC_251 melphalan 456.522 µM -0.827499546843825 0.206458325290674 no 2684 0.203976989412575 3912 460612 A DNA alkylator. SGTC_2351 9026858 72.31 µM -0.828305745860386 0.206232890724713 no 2685 0.203748684814644 3810 1409300 SGTC_2038 4100038 30.985 µM -0.828427054116266 0.206198982362187 no 2686 0.203714345156665 3890 3596803 SGTC_2846 9008642 19.48 µM -0.829362635796722 0.205937577478174 no 2687 0.203449618826139 3948 2992898 SGTC_2692 st077426 47.7 µM -0.82980619557475 0.205813714002131 no 2688 0.203324183676068 3874 25238571 SGTC_2016 5121758 140 µM -0.830096268868639 0.20573273533327 no 2689 0.203242178237393 3833 2795203 SGTC_2102 5377816 72.7585 µM -0.830915837510401 0.205504041647661 no 2690 0.203010588030291 3914 1379702 SGTC_2518 prenyletin 46.28 µM -0.831229556437345 0.205416541002757 no 2691 0.202921980397781 3823 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2593 nobiletin 86.24 µM -0.836328496399093 0.203997479254514 no 2692 0.201485063073864 3896 72344 An anti-infammatory. SGTC_715 0868-0130 184 µM -0.836958681591677 0.203822501869486 no 2693 0.201307896754819 3902 2876258 SGTC_1231 0242-0792 125 µM -0.837855866384515 0.203573543706228 no 2694 0.201055829020484 3881 3707635 SGTC_3073 9114972 49.47 µM -0.838011122397994 0.203530480414155 no 2695 0.201012228431887 3842 41905075 SGTC_1300 1094-0077 113 µM -0.838773557859825 0.203319082895579 no 2696 0.200798195804829 3839 5532636 SGTC_1741 st038134 10.228 µM -0.842326051959355 0.202335825496282 no 2697 0.199802736220575 3950 1272587 SGTC_1177 0983-0204 23.6 µM -0.842710873490804 0.202229485784196 no 2698 0.199695082212334 3941 766818 SGTC_2461 5755302 26.15 µM -0.844289210414847 0.20179368572301 no 2699 0.19925390692721 3936 2788904 SGTC_1793 st048256 72.231 µM -0.844492222527228 0.201737672194767 no 2700 0.199197203805296 3778 672022 SGTC_2055 5235184 200 µM -0.845205825517102 0.201540854293606 no 2701 0.198997965166713 3945 2836034 SGTC_319 1348-1596 45.5 µM -0.846034942636164 0.201312321141571 no 2702 0.198766625750972 3983 5380505 SGTC_411 enrofloxacin 100 µM -0.847696808215936 0.20085472191055 no 2703 0.198303422186144 3999 71188 A bacterial gyrase inhibitor. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.848933950149266 0.200514477128731 no 2704 0.197959023119172 3946 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_76 0433-0009 400.328 µM -0.850614072542967 0.200052956346912 no 2705 0.197491884789914 4014 2841569 SGTC_2074 5212007 75.395 µM -0.8518305661561 0.199719190882844 no 2706 0.197154069372718 3760 758611 SGTC_1414 3917-0015 5.4 µM -0.853774031295683 0.199186664217631 no 2707 0.196615102905122 3849 6618702 SGTC_1729 st035615 45.989 µM -0.854466547595784 0.198997115484687 no 2708 0.196423268504557 3958 17385451 SGTC_3302 9125395 16.351 µM -0.854828036988108 0.198898215364882 no 2709 0.196323177164878 3861 17599668 SGTC_1206 3978-0017 132 µM -0.855025147330216 0.198844300300668 no 2710 0.196268613105573 4020 3873677 SGTC_3075 9116269 49.47 µM -0.85537709820502 0.198748054031559 no 2711 0.196171208977652 3927 17015205 YNL244C SUI1 SGTC_2040 5100729 123 µM -0.855730417197396 0.198651461887657 no 2712 0.196073455706846 3913 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_923 1900-2434 73.3 µM -0.856989521656905 0.198307471778856 no 2713 0.195725337794353 3875 5910570 SGTC_281 1672-3440 14.9 µM -0.857096775046942 0.198278186541745 no 2714 0.195695701666471 3949 6833000 SGTC_2915 7971052 15.16 µM -0.85721062262091 0.198247103637307 no 2715 0.195664246422216 3777 5741558 SGTC_3024 9090631 49.47 µM -0.858688750936118 0.197843808977012 no 2716 0.19525612916642 3863 25236383 SGTC_1101 ebselen 5.29 µM -0.859483434463738 0.19762719140245 no 2717 0.195036927762565 3969 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1049 3226-0134 66 µM -0.860082235101678 0.19746406300817 no 2718 0.194871856558713 3941 5702385 SGTC_2762 leflunomide 42.06 µM -0.86151164784556 0.197074984223678 no 2719 0.1944781543816 3890 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_506 n9-isopropylolomoucine 153 µM -0.862106711835755 0.196913147741557 no 2720 0.194314399140933 3897 6610355 SGTC_512 prima-1 270 µM -0.863682093842094 0.196485087853675 no 2721 0.193881276410168 3940 322968 A re-activator of the apoptotic function of mutant p53. SGTC_186 3455-3465 67.277 µM -0.864882764522915 0.196159222800581 no 2722 0.193551569214995 3865 755278 SGTC_3105 9121040 49.47 µM -0.864931819710611 0.196145916071111 no 2723 0.193538105812221 3740 41448907 SGTC_1569 carminic acid 40.6 µM -0.865151185055134 0.196086417639325 no 2724 0.193477907058755 3993 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2175 5807670 165.306 µM -0.865349463843363 0.196032647931109 no 2725 0.193423504756919 3913 241186 SGTC_2757 clomiphene 4.22 µM -0.865781705051012 0.195915462748076 no 2726 0.193304941888175 3978 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2118 5526350 200 µM -0.867580585101808 0.195428223957677 no 2727 0.192811989355962 3979 743594 SGTC_1453 4237-0541 195 µM -0.868097137832229 0.195288448304102 no 2728 0.192670578900316 3861 739892 SGTC_149 3970-0822 46.1 µM -0.868392330910691 0.195208598347362 no 2729 0.19258979589186 3939 3114250 YBL034C STU1 SGTC_2612 dictamnine 15.46 µM -0.86920034750116 0.194990130738234 no 2730 0.192368778695144 3916 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2952 9073731 13.78 µM -0.871309451809755 0.194420582151174 no 2731 0.191792605521221 4001 16457353 SGTC_515 4092-1064 102 µM -0.871685762120679 0.194319068803739 no 2732 0.191689914824701 3934 717353 SGTC_982 1491-0518 27.5 µM -0.871925413311125 0.194254437400714 no 2733 0.191624534362687 3866 3091256 SGTC_2145 5634607 200 µM -0.872610480134 0.194069754301932 no 2734 0.19143771313427 3895 308662 SGTC_307 1501-1223 22.3 µM -0.875141989362748 0.193388228248161 no 2735 0.19074832633633 3948 2830329 SGTC_1873 rapamycin 2 nM -0.875583172533954 0.193269603708861 no 2736 0.190628338330754 3914 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1278 0874-0585 172 µM -0.876095670553905 0.193131859930563 no 2737 0.190489013103359 3997 766306 SGTC_2343 7990716 14.84 µM -0.877414164327738 0.192777764691868 no 2738 0.190130861223791 3931 6456862 SGTC_2465 5809242 33.21 µM -0.877672926844625 0.192708317911206 no 2739 0.190060620317867 3953 2731748 SGTC_2308 7584454 197.62 µM -0.878126842493556 0.192586532794606 no 2740 0.189937443761156 3965 893577 SGTC_337 1315-0038 354 µM -0.879761775072711 0.192148272009872 no 2741 0.189494188090168 3907 1626437 SGTC_2723 salbutamol 83.58 µM -0.88001633070571 0.192080090647381 no 2742 0.189425231408686 3956 9884233 β2-adrenoceptor agonist SGTC_941 3237-0776 460 µM -0.880095838932517 0.192058797829179 no 2743 0.189403696557488 3983 760008 SGTC_2419 paclitaxel 166.5 µM -0.88030244572694 0.192003473944795 no 2744 0.189347744027957 3871 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1740 st038286 13.222 µM -0.881174146135861 0.191770162822601 no 2745 0.189111785211359 4006 716786 SGTC_3156 9099931 49.47 µM -0.883259929847269 0.191212606631926 no 2746 0.188547924125255 3962 18111053 SGTC_1421 4029-0249 71.4 µM -0.883366754159952 0.191184077928509 no 2747 0.188519073669677 4017 2894095 SGTC_2437 5741531 144.16 µM -0.884663755453333 0.190837906526595 no 2748 0.188169004715281 3972 2262990 SGTC_2987 9018338 71.43 µM -0.886402138509926 0.19037453333765 no 2749 0.187700433628981 3991 5055682 SGTC_2656 pseudo-anisatin 100 µM -0.889372763936205 0.189584301869389 no 2750 0.18690138874705 3976 6708809 A neurotoxin. SGTC_884 0851-0618 334 µM -0.889531382602115 0.189542163727907 no 2751 0.186858782454055 3977 9642473 SGTC_555 4296-0685 37 µM -0.890582185338419 0.189263156304265 no 2752 0.186576679925945 3895 2908540 YHR072W ERG7 SGTC_1622 st003707 19.4 µM -0.893702347482819 0.18843618711169 no 2753 0.185740584526231 3993 10140899 SGTC_2357 9067248 200 µM -0.89370725482558 0.188434888225116 no 2754 0.185739271361647 3964 9150235 SGTC_173 1273-0061 2.693 µM -0.895710204669022 0.187905204083679 no 2755 0.185203779403377 3961 2847414 YPL266W DIM1 SGTC_818 4072-2707 53.5 µM -0.896314160204404 0.187745667395877 no 2756 0.185042499219245 3887 882871 SGTC_138 0850-0259 40.9225 µM -0.898436398475608 0.187185735526068 no 2757 0.184476469359081 3948 6813004 SGTC_433 pimozide 108 µM -0.899458284007918 0.186916489736966 no 2758 0.184204303118512 3883 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1 0258-0098 57.368 µM -0.899955872260291 0.186785472279155 no 2759 0.184071867320568 3900 6790032 YDR047W HEM12 SGTC_2913 7966556 36.57 µM -0.899958562061097 0.186784764195744 no 2760 0.18407115157669 3826 2976516 SGTC_1790 st045711 43.5 µM -0.900670775938109 0.186597334118457 no 2761 0.183881695641302 3955 585119 SGTC_1348 1493-0373 93.8 µM -0.901117180405769 0.186479915284866 no 2762 0.183763009575522 3962 3010129 SGTC_571 k831-0106 44.2 µM -0.901303855065885 0.186430827375576 no 2763 0.183713392324106 3861 4783639 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.901769746792589 0.186308351554309 no 2764 0.183589596896681 3995 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3214 9129694 49.47 µM -0.903900355464634 0.185748882596726 no 2765 0.183024120335662 3992 17158655 SGTC_943 3253-1379 105 µM -0.904951896757897 0.18547314661737 no 2766 0.182745435808569 3966 668464 SGTC_1267 0828-0272 9.49 µM -0.905674454749453 0.18528382424193 no 2767 0.182554093661451 4065 745334 SGTC_2684 capsaicin 100 µM -0.906932027689907 0.184954605221906 no 2768 0.182221371571398 4006 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2890 9046729 58.44 µM -0.907476390957608 0.184812209589735 no 2769 0.182077464389527 3911 903329 SGTC_1883 5-benzylidenerhodanine 20 µM -0.9088514929236 0.18445281124832 no 2770 0.181714260721923 3982 1273210 SGTC_989 1501-0895 10.3 µM -0.909160737403647 0.184372046649079 no 2771 0.181632642906123 3926 2830112 SGTC_2707 st078556 66.6 µM -0.910631790150153 0.183988156852485 no 2772 0.181244707276276 3946 17250899 SGTC_1856 st057054 55.7 µM -0.911441922891465 0.183776955155737 no 2773 0.181031286541599 4012 1266018 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.911803592761736 0.183682716560452 no 2774 0.180936059374028 4048 6710655 SGTC_426 0988-0037 14.6 µM -0.912252268763468 0.18356584904539 no 2775 0.180817967251449 4013 5383008 SGTC_2621 lithochol-11-enic acid 100 µM -0.913367886859183 0.183275462737476 no 2776 0.1805245445562 3906 6708711 SGTC_1553 gossypol 38.6 µM -0.913368560386239 0.183275287510436 no 2777 0.180524367499702 3843 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1344 1488-0097 29.1 µM -0.913862892643481 0.183146708563083 no 2778 0.180394447029723 4014 747966 SGTC_420 mitomycin C 81.9 mM -0.914272213602047 0.183040284188336 no 2779 0.180286913650058 3972 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_675 1309-0189 238 µM -0.914700168360666 0.182929056250926 no 2780 0.180174527978215 4013 4246530 SGTC_940 3232-1287 54.8 µM -0.917217743978541 0.182275577913197 no 2781 0.179514275251751 3878 1585493 YIL048W NEO1 SGTC_478 N-arachidonylglycine 10 µM -0.917517234793865 0.182197937334678 no 2782 0.179435832925188 3934 5283389 SGTC_2105 5350118 200 µM -0.919560759081847 0.18166872199127 no 2783 0.178901170437561 3980 2133313 SGTC_3352 9151559 45.5865 µM -0.919586336847414 0.181662104169642 no 2784 0.178894484695867 3992 17159339 SGTC_1288 0973-0013 65.5 µM -0.919643283363118 0.181647370747195 no 2785 0.178879600078717 4035 4315430 SGTC_570 0987-0065 62.6 µM -0.920650836099044 0.181386816472766 no 2786 0.178616375970889 3783 3104428 SGTC_3218 9131285 49.47 µM -0.923589154050034 0.180628301239065 no 2787 0.177850131446394 3950 17156417 SGTC_195 4234-0266 16.654 µM -0.926311710689916 0.17992726205042 no 2788 0.177142005881183 3997 2303354 SGTC_1686 st019653 115.5 µM -0.927600661013052 0.179595963194278 no 2789 0.176807377356529 3962 97252 SGTC_3319 9138450 16.7555 µM -0.927815200567326 0.179540857338498 no 2790 0.176751718868702 3946 2029690 SGTC_1066 ketoconazole 628 nM -0.928044701851925 0.17948192023276 no 2791 0.176692191088593 4064 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_407 eburnamonine 100 µM -0.929048912974996 0.179224176724985 no 2792 0.176431869060473 3862 3195 SGTC_1655 st012546 55.1 µM -0.929685283535825 0.179060964720823 no 2793 0.176267028138545 3998 720985 YLR208W SEC13 SGTC_2789 5281112 71.43 µM -0.929716940430086 0.179052848017705 no 2794 0.176258830506472 4039 765948 SGTC_2122 5258151 111.688 µM -0.931706633245189 0.178543163164477 no 2795 0.175744078743308 4005 2173356 SGTC_2744 captopril 92.04 µM -0.93310148934259 0.178186398628822 no 2796 0.175383785118889 4026 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3298 9116858 71.43 µM -0.933940316497482 0.177972067001823 no 2797 0.175167340330283 4079 2506942 SGTC_2941 9056145 11.23 µM -0.934418498699726 0.177849957797312 no 2798 0.175044029564647 3872 2119517 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.935615696876184 0.177544471614818 no 2799 0.174735544871368 4057 688664 SGTC_659 k018-0002 107 µM -0.936064480639353 0.177430041932216 no 2800 0.174619994759469 4029 6797879 YHR007C ERG11 SGTC_1628 st004252 77.7 µM -0.936165983095819 0.177404167565 no 2801 0.174593867254155 4052 692968 SGTC_2219 9098279 200 µM -0.937185017270835 0.177144533809379 no 2802 0.174331697676951 3953 902349 SGTC_2303 7774051 200 µM -0.938263024733627 0.176870135994796 no 2803 0.174054628291053 4040 2953184 SGTC_2036 5160441 105 µM -0.940720159184671 0.176245697540019 no 2804 0.173424142698544 3998 134534 YIL048W NEO1 SGTC_1716 st033144 30.6155 µM -0.940875001486096 0.176206393818126 no 2805 0.173384459868088 4019 674617 SGTC_796 1234-0020 70.7 µM -0.940878652667463 0.17620546710334 no 2806 0.173383524216735 3956 46495034 SGTC_992 3909-8734 162 µM -0.94124755845855 0.176111850172434 no 2807 0.173289005026556 4029 4288319 SGTC_3342 9147791 14.508 µM -0.94466809458134 0.175245323332835 no 2808 0.172414175307795 3920 1838168 SGTC_866 0495-0101 262 µM -0.944974487501425 0.175167836759397 no 2809 0.172335950552511 3993 635694 SGTC_71 0417-1750 47.813 µM -0.9450571118535 0.175146944834364 no 2810 0.172314859719485 4040 6811472 SGTC_1019 4262-0212 3.4 µM -0.947050813237526 0.174643308051074 no 2811 0.171806443429011 4054 4677213 SGTC_1458 k015-0034 6.33 µM -0.947113941922887 0.174627375898096 no 2812 0.171790360567226 4054 3598957 SGTC_2221 6807166 181.081 µM -0.947836378395222 0.174445116125968 no 2813 0.17160637885482 3961 674925 SGTC_1459 k035-0031 35.7 µM -0.950023093397172 0.17389417779886 no 2814 0.171050259286144 3836 3877128 YMR208W ERG12 SGTC_1618 st003135 44.5 µM -0.951053195039609 0.1736350296355 no 2815 0.170788686433721 3925 1270615 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.951076408310652 0.173629192581622 no 2816 0.170782794858033 4074 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1531 st059297 52.4 µM -0.953874798736299 0.172926442887413 no 2817 0.170073510701101 4042 7566702 SGTC_640 3381-0960 37.1 µM -0.956455692036768 0.1722799213647 no 2818 0.169421029728538 4083 1745025 SGTC_596 1155-0152 116 µM -0.959313425786501 0.171565852173304 no 2819 0.168700436919494 4037 280313 SGTC_2304 7443016 91.4 µM -0.96042331305822 0.171289032422876 no 2820 0.168421104776181 3958 939854 SGTC_601 0986-0029 62.9 µM -0.962233552552317 0.170838149132175 no 2821 0.167966149231005 4001 24747981 SGTC_2300 7976697 71.57 µM -0.962719209322064 0.170717314066417 no 2822 0.167844227021611 3944 2236109 SGTC_2128 5255449 168.493 µM -0.963370005546448 0.170555476851709 no 2823 0.167680936561087 4039 736008 SGTC_719 2810-4230 27.3 µM -0.968020666261336 0.169401830984185 no 2824 0.166517024306442 4040 721079 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.968106042692397 0.169380699372034 no 2825 0.166495706169342 4040 140250 A respiratory chain inhibitor. SGTC_775 4577-0580 57.3 µM -0.968920602678353 0.169179171831623 no 2826 0.166292402552755 4123 2006902 SGTC_2930 9013230 14.89 µM -0.969351718383808 0.169072573277208 no 2827 0.166184866568403 4078 2995857 SGTC_1505 k297-0037 20.6 µM -0.971465643381158 0.168550504320397 no 2828 0.165658226865642 4074 4089396 SGTC_2417 cerulenin 830 nM -0.971820473825414 0.168462974724515 no 2829 0.165569934256415 4086 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1788 fluconazole 20 µM -0.972934577498209 0.168188337554511 no 2830 0.165292909211355 4102 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1313 1220-0047 237 µM -0.975535877789562 0.167548214399356 no 2831 0.164647256975579 4037 3528706 SGTC_3290 9121031 71.43 µM -0.975750120835771 0.167495563910822 no 2832 0.164594154001475 4078 17014854 SGTC_955 1216-0110 33 µM -0.976638097708757 0.167277456176604 no 2833 0.164374175527834 4037 3619719 SGTC_2341 7987486 176.74 µM -0.976659277777605 0.167272256096221 no 2834 0.164368930918645 4100 1258686 SGTC_287 k060-0039 29.6 µM -0.977577401656724 0.167046940649377 no 2835 0.164141689341889 4118 5861974 SGTC_133 0724-0033 378.92 µM -0.977718953307107 0.167012220085253 no 2836 0.164106672534472 3905 280309 SGTC_1970 st070122 35.8 µM -0.978034709529507 0.166934786440245 no 2837 0.164028578756543 4093 102928 SGTC_2337 9009472 200 µM -0.979028027308071 0.16669134380068 no 2838 0.163783065663711 4013 5742383 SGTC_1292 0kpi-0043 232 µM -0.97956424219683 0.166560023345955 no 2839 0.163650631453007 4079 3333905 SGTC_1289 0976-0073 69.1 µM -0.981759871119447 0.16602300471539 no 2840 0.163109081000426 4124 3391136 SGTC_2135 5326629 150.42 µM -0.984231204026531 0.165419892821774 no 2841 0.162500923273666 4030 5020077 SGTC_1875 nocodazole 6 µM -0.986254506781262 0.164927176230448 no 2842 0.162004118965694 4089 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2493 resveratrol 26.09 µM -0.990973031492408 0.163781813326831 no 2843 0.160849374539959 3961 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2998 9066762 71.4286 µM -0.991765610419679 0.163589932341935 no 2844 0.160655938484591 4131 4945196 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.992597858252187 0.163388604806686 no 2845 0.160452984466514 4063 688667 SGTC_2015 5119600 184 µM -0.993343905690759 0.163208266712379 no 2846 0.160271193940362 4121 2828786 SGTC_237 nikkomycin 200 µM -0.994073843136357 0.163031948032153 no 2847 0.160093459301956 4097 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1570 verbenone 133 µM -0.994555819742629 0.162915592967857 no 2848 0.159976172052103 4100 29025 A natural terpanoid with antifungal properties. SGTC_3074 9116018 49.47 µM -0.99662122862302 0.162417589536484 no 2849 0.159474198867412 4144 17027303 SGTC_774 k060-0086 136 µM -0.998205914512162 0.162036168594628 no 2850 0.159089759517346 4060 5911235 SGTC_1889 st059080 5.18 µM -0.998310531868207 0.162011008597583 no 2851 0.159064401088025 4031 176925 Isolated from Daphnopsis sellowiana. SGTC_3103 9120822 49.47 µM -0.999513583635481 0.16172186302778 no 2852 0.15877298107684 4117 17141819 SGTC_2855 9016525 58.44 µM -1.00034063133833 0.161523282755707 no 2853 0.158572845157623 4047 43811474 SGTC_713 1488-1073 324 µM -1.00094243671196 0.161378884805181 no 2854 0.158427319295055 4014 3312542 SGTC_1185 1319-0113 81.3 µM -1.00439855885995 0.16055124902265 no 2855 0.157593272192257 4164 4672763 SGTC_2349 9023730 187.07 µM -1.00453023620994 0.160519771244599 no 2856 0.157561552372453 4111 4126287 SGTC_1098 clofazimine 15.1 µM -1.00913184653708 0.159422278058766 no 2857 0.15645570331323 4155 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1257 0669-0121 16 µM -1.01113005114467 0.158947235713182 no 2858 0.155977094512665 4119 4307855 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.01648799378218 0.157678050367145 no 2859 0.154698530992128 4057 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1003 4049-0218 100 µM -1.01686462043875 0.15758908646669 no 2860 0.154608917982501 4142 295161 SGTC_3104 9120930 49.47 µM -1.01710484069144 0.157532360684914 no 2861 0.154551778878393 4142 17014836 SGTC_3304 9125678 46.087 µM -1.01951215066759 0.156964637855087 no 2862 0.153979943820114 4043 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_965 1291-5240 308 µM -1.02033252294848 0.156771474980766 no 2863 0.153785391929031 4131 2834598 SGTC_676 falcarinol 140 µM -1.02162090159096 0.156468432350569 no 2864 0.153480180548716 4126 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_455 paf C-16 10 µM -1.02218591996864 0.156335654779667 no 2865 0.153346456754646 4090 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_890 0929-0006 47.2 µM -1.02367600754597 0.155985844848641 no 2866 0.152994165674285 4084 1378169 SGTC_2598 perillyl alcohol 100 µM -1.02384634942534 0.155945888619543 no 2867 0.152953927125374 4159 10819 An apoptosis inducer. SGTC_403 arphamenine a 50 µM -1.02439692645821 0.155816788709631 no 2868 0.152823916551885 4076 5487158 An arginine aminopeptidase inhibitor. SGTC_1047 2043-3044 82 µM -1.02442448610877 0.1558103283448 no 2869 0.152817410677072 4112 669592 SGTC_503 tyrphostin 8 294 µM -1.02776006894635 0.155029725592875 no 2870 0.15203135194115 4123 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2874 9043904 71.43 µM -1.02895578332561 0.154750530929367 no 2871 0.151750226620531 4070 4463428 SGTC_2075 5212009 200 µM -1.03094969692222 0.154285699154211 no 2872 0.151282204869538 4027 780898 SGTC_2297 7971671 152.32 µM -1.03305812241976 0.153795177159439 no 2873 0.150788349755736 4142 909016 SGTC_2285 7945142 200 µM -1.03389745649899 0.153600194934291 no 2874 0.150592052109071 4179 2970608 SGTC_1555 citronellol 128 µM -1.03455132302607 0.153448411386391 no 2875 0.150439248321002 4086 8842 A terpine precursor. SGTC_458 nppb 133 µM -1.03593240527082 0.153128144206562 no 2876 0.150116839193941 4161 4549 A chloride channel blocker. SGTC_326 k292-0812 17.5 µM -1.03610945330495 0.153087119570388 no 2877 0.150075541244063 4111 3579357 SGTC_1277 0873-0036 22 µM -1.03657369290258 0.152979583018993 no 2878 0.149967289407515 4210 5965735 SGTC_2242 6630449 61.2675 µM -1.03945211379929 0.152313943144172 no 2879 0.149297258914855 4187 691249 YDR170C SEC7 SGTC_930 2810-3379 265 µM -1.0395158917267 0.15229921619167 no 2880 0.149282435542683 4171 1015764 SGTC_3212 9128307 49.47 µM -1.04191794087423 0.151745247555495 no 2881 0.148724862730091 4090 27243542 SGTC_1172 0370-0043 85 µM -1.0444897656789 0.151153610858872 no 2882 0.148129425891879 4157 376585 SGTC_2718 lomofungin 53.02 µM -1.04488040167922 0.151063881244078 no 2883 0.148039124381523 4128 5351222 A RNA synthesis inhibitor. SGTC_924 2046-0044 21.3 µM -1.04678499767153 0.150626900761336 no 2884 0.147599375583343 4124 3623589 SGTC_3018 9082602 49.47 µM -1.05055840819326 0.149763637694748 no 2885 0.146730725937303 4096 17332089 SGTC_2720 fluspirilene 36.88 µM -1.05315159246522 0.149172298331224 no 2886 0.146135760167636 4151 3396 An atypical antipsychotic. SGTC_41 0478-0632 82.643 µM -1.05485929675113 0.148783732968913 no 2887 0.145744840155587 4091 3750424 SGTC_1323 1348-1351 11.2 µM -1.05537017163343 0.148667621764196 no 2888 0.145628029694749 4098 6989654 SGTC_1905 st060207 84.5 µM -1.05599831977704 0.14852493984096 no 2889 0.145484491252223 4122 1948547 SGTC_3065 9113888 49.47 µM -1.05951746195537 0.147727271356418 no 2890 0.144682090487386 4224 16648368 SGTC_2073 5212005 126 µM -1.06344951262288 0.146839410259336 no 2891 0.143789074647393 3965 691789 SGTC_1562 morin hydrate 59.1 µM -1.06629278807479 0.146199630264674 no 2892 0.143145654310221 4223 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_311 1315-0136 58 µM -1.06845880174953 0.145713502614738 no 2893 0.142656802356189 4184 6759207 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.06950187034303 0.145479790374684 no 2894 0.142421793261956 4210 5357218 A potent inhibitor of glutathione S-transferases. SGTC_599 1935-0052 86.5 µM -1.07035029139625 0.145289877316895 no 2895 0.142230832571171 4153 9557311 SGTC_876 0720-0963 56.8 µM -1.07139086643417 0.145057179781652 no 2896 0.141996858960186 4178 765861 SGTC_1149 3909-7961 23.3 µM -1.07218302316161 0.14488020279908 no 2897 0.141818917058215 4212 735261 SGTC_56 0957-0365 83.25 µM -1.07308733239571 0.144678347431288 no 2898 0.141615967039675 4147 6752360 SGTC_2177 5811945 192 µM -1.0749236055118 0.144269046873899 no 2899 0.141204466253409 4217 5343475 SGTC_2974 9094440 9.66 µM -1.07575443929486 0.144084112882664 no 2900 0.141018546672559 4187 25236134 SGTC_3263 9137018 49.47 µM -1.07646985741835 0.143924997225059 no 2901 0.140858587285501 4143 43844957 SGTC_562 3772-2733 112 µM -1.07878009412781 0.143411988637089 no 2902 0.14034288533755 4156 2876874 YIL048W NEO1 SGTC_3087 9117406 49.47 µM -1.07905727969637 0.143350520173917 no 2903 0.140281096921438 4194 42546093 SGTC_1355 1499-0035 1.68 µM -1.07913050398586 0.14333428498163 no 2904 0.140264777321384 4169 1548538 SGTC_2079 5212404 121 µM -1.07937861246007 0.143279283931397 no 2905 0.140209490624715 4149 758462 SGTC_705 1124-0212 310 µM -1.07974894653902 0.143197214248574 no 2906 0.140126995598348 4159 9554485 SGTC_1808 st050063 61.5 µM -1.08169820423258 0.142765762997166 no 2907 0.139693325683739 4163 4011993 SGTC_1457 k015-0032 57.3 µM -1.08265559234102 0.142554175588778 no 2908 0.139480660949085 4171 4302660 SGTC_99 0109-0120 622.8 µM -1.08351257450916 0.142364958340206 no 2909 0.139290486269264 4142 759414 SGTC_1369 1866-0067 208 µM -1.0840403793796 0.142248506328166 no 2910 0.139173447833145 4196 3531355 SGTC_2852 9023854 51.95 µM -1.0846982196642 0.142103454260689 no 2911 0.13902766832611 4228 19798528 SGTC_2970 9090938 41.86 µM -1.08507102677839 0.14202129572316 no 2912 0.138945099243267 4254 17217104 SGTC_1072 oxiconazole 14.9 nM -1.08618879859558 0.141775156018606 no 2913 0.138697736005105 4165 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_681 1642-0006 26.6 µM -1.08799172045225 0.141378751529516 no 2914 0.138299381328071 4200 4446530 SGTC_2569 tetrandrine 100 µM -1.09282063952347 0.140320730915995 no 2915 0.137236278870964 4203 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_280 3448-3607 3.04 µM -1.09360199244928 0.140150042502159 no 2916 0.137064787505453 4152 626179 SGTC_351 caspofungin 25 nM -1.09614630724087 0.139595208590142 no 2917 0.136507376157235 4196 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1405 3909-7894 12 µM -1.09681035546544 0.139450646981284 no 2918 0.136362151213105 4188 7104060 SGTC_78 0336-0123 156.75 µM -1.09733309994604 0.139336918495808 no 2919 0.136247903266008 4021 6765896 SGTC_2253 7938677 135.83 µM -1.10019866278333 0.13871460681212 no 2920 0.135622786555351 4256 2301972 SGTC_1362 1611-0397 101 µM -1.10070005368463 0.138605915113117 no 2921 0.135513611444694 4159 27816 SGTC_1081 sertraline 6 µM -1.10318219627461 0.1380686901007 no 2922 0.134974025641517 4185 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2141 5621638 7.665 µM -1.10401312885007 0.137889164054938 no 2923 0.134793721296706 4216 2856238 SGTC_810 3825-7150 143 µM -1.10612588349632 0.137433413084993 no 2924 0.134336018482709 4279 22330411 YGL099W LSG1 SGTC_1192 1488-0095 21.4 µM -1.10852447370964 0.136917251269995 no 2925 0.133817687796961 4261 915875 SGTC_2871 9038510 12.99 µM -1.10874206605013 0.136870492372937 no 2926 0.133770734617752 4170 4945164 SGTC_3235 9132602 49.47 µM -1.10888462832929 0.136839862769653 no 2927 0.133739977947223 4209 4912240 SGTC_2077 5212015 200 µM -1.10941258899486 0.13672647086544 no 2928 0.133626117000837 4058 780900 SGTC_889 0919-1524 82.7 µM -1.10986237242578 0.136629920039992 no 2929 0.133529168491912 4226 3905452 SGTC_2137 5261020 140 µM -1.11016103412599 0.136565834873381 no 2930 0.133464820226873 4161 763655 SGTC_2611 pyromycin 23.93 µM -1.11141750402754 0.136296453723002 no 2931 0.133194340679622 4169 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3107 9121808 49.47 µM -1.11204568473481 0.13616191119033 no 2932 0.133059254117047 4118 662681 SGTC_3143 9086658 49.47 µM -1.11359757775611 0.135829919481851 no 2933 0.132725933024253 4245 25236626 SGTC_2880 9042983 58.44 µM -1.11479436667402 0.135574272983251 no 2934 0.132469275528073 4198 6464714 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.11856819523797 0.134770303750579 no 2935 0.131662199099292 4194 688803 SGTC_480 am 92016 50 µM -1.12039087635837 0.134383177117971 no 2936 0.131273615580048 4199 2129 K+ channel blocker. SGTC_2133 5320837 200 µM -1.12077817434828 0.134301015787354 no 2937 0.131191148348124 4253 2841355 SGTC_3316 9136639 10.545 µM -1.12146328823866 0.13415576034344 no 2938 0.131045354924584 4214 4903665 SGTC_1690 st023502 41.2 µM -1.12351483538041 0.13372144410061 no 2939 0.130609451743818 4218 24207482 SGTC_1132 3456-3614 2.5 µM -1.12375368004147 0.133670943144861 no 2940 0.130558768372151 4270 3125502 SGTC_2468 5987765 72.9 µM -1.125859077061 0.133226348413701 no 2941 0.130112586721595 4258 26772094 SGTC_2673 kobusone 100 µM -1.12934864886114 0.132491701788519 no 2942 0.129375393019345 4310 6710676 An epoxy ketone and protein crosslinker. SGTC_366 0181-0206 4.31 µM -1.1308834448418 0.132169472350639 no 2943 0.129052076075021 4250 274874 SGTC_832 4083-0019 164 µM -1.13236218462071 0.131859523335786 no 2944 0.128741098159573 4298 1990758 SGTC_2872 9044037 25.97 µM -1.13296386016883 0.131733553671412 no 2945 0.128614715150179 4241 6465195 SGTC_2103 5378138 10 µM -1.13393570617041 0.131530258783781 no 2946 0.128410759079706 4287 244142 SGTC_2571 chrysanthemic acid 100 µM -1.13425164367186 0.131464216298735 no 2947 0.128344503369693 4226 2743 An insecticide. SGTC_387 norethindrone acetate 66.7 µM -1.13683640550717 0.13092476635225 no 2948 0.127803340611336 4244 541197 SGTC_1735 st034310 56.75 µM -1.13840644924689 0.130597839822325 no 2949 0.127475401157743 4289 871153 SGTC_357 1325-0123 420 µM -1.13850562536244 0.130577207582827 no 2950 0.127454705630386 4242 1098503 SGTC_1932 st074806 40.9 µM -1.14232222981843 0.12978492691975 no 2951 0.126660052181293 4307 17251235 SGTC_1266 0828-0227 32.9 µM -1.14239454600499 0.129769947163088 no 2952 0.12664502864424 4226 3913820 SGTC_509 pifithrin 175 µM -1.14980252365042 0.128241779865891 no 2953 0.125112607797583 4314 4817 A p53 inhibitor. SGTC_2568 diosmetin 100 µM -1.15180186253476 0.127831493026029 no 2954 0.124701251178722 4287 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3274 9138298 49.47 µM -1.15218140044266 0.127753710709885 no 2955 0.124623269525014 4229 17015756 SGTC_2910 7948405 25.97 µM -1.15696871079085 0.126775425398397 no 2956 0.123642572053594 4151 2971328 SGTC_3328 9140624 29.0385 µM -1.15770328710222 0.126625777792996 no 2957 0.123492571039743 4258 4904392 SGTC_2780 5215298 71.43 µM -1.15788320198777 0.126589144365241 no 2958 0.123455851730662 4266 2834131 SGTC_1996 st072960 66.8 µM -1.15799848099554 0.126565675673277 no 2959 0.123432328150826 4280 1719405 SGTC_1041 0206-0046 107 µM -1.15872609522375 0.126417616691271 no 2960 0.123283925249611 4247 50494 SGTC_1548 st061468 90.8 µM -1.1595487119931 0.126250371453535 no 2961 0.123116296425029 4238 390799 SGTC_2917 7979103 53.79 µM -1.16153925359676 0.12584631501969 no 2962 0.122711334763638 4283 2980565 SGTC_2601 securinine 100 µM -1.16407844014406 0.125332200411315 no 2963 0.122196112490458 4235 442872 A GABA receptor antagonist. SGTC_3134 9127454 49.47 µM -1.16498520199879 0.12514896215278 no 2964 0.122012491435543 4311 24262820 SGTC_1892 st058411 7.36 µM -1.17012847406356 0.124113151012009 no 2965 0.120974635642385 4268 3934738 SGTC_50 0929-0078 56.389 µM -1.17020299532938 0.124098187278475 no 2966 0.120959643862017 4107 1377751 SGTC_2218 6965428 192.983 µM -1.17160017421602 0.123817869985413 no 2967 0.120678809050253 4171 675684 SGTC_3173 9105693 49.47 µM -1.17206541057752 0.123724627628656 no 2968 0.120585397873433 4268 17096658 SGTC_123 0083-0120 66.675 µM -1.17512837834068 0.123111976958831 no 2969 0.119971679369032 4243 16001701 SGTC_2765 myclobutanil 7.74 µM -1.1753810014282 0.123061542716198 no 2970 0.119921160430822 4291 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.17631687682075 0.122874828660602 no 2971 0.119734137084269 4287 551469 SGTC_2492 derrusnin 100 µM -1.1787292117049 0.122394466247381 no 2972 0.119253009881623 4278 1715307 Part of coumarin class of compounds. SGTC_3064 1327-0027 10 µM -1.18072036913138 0.121998965968216 no 2973 0.118856913483619 4192 16000455 YPR107C YTH1 SGTC_275 trichlorophene 5.69 µM -1.18098692530286 0.121946088559192 no 2974 0.118803958679564 4304 62616 SGTC_2254 7938975 95.19 µM -1.18247133201325 0.121651917550217 no 2975 0.118509367051331 4344 2969277 SGTC_1525 8-methoxypsoralen 92.5 µM -1.18350205562742 0.12144794838151 no 2976 0.118305116159891 4322 4114 Related to psoralen; DNA damaging agent. SGTC_1432 4049-0298 68.4 µM -1.18414917050474 0.121320014196231 no 2977 0.118177009427241 4293 741646 SGTC_2281 7943571 200 µM -1.18438479219884 0.121273455485145 no 2978 0.118130388717665 4380 1244024 SGTC_1467 k284-1082 293 µM -1.18540703147632 0.121071607108632 no 2979 0.117928276476281 4244 3334705 SGTC_760 0568-0725 82.9 µM -1.18866049132472 0.120430761983492 no 2980 0.117286646773935 4301 3916171 SGTC_985 1493-0307 8.71 µM -1.1921055066987 0.119754793719709 no 2981 0.116609939036683 4298 3278274 SGTC_573 3702-0553 84.7 µM -1.19220830422165 0.119734664358852 no 2982 0.116589789048937 4236 1222756 SGTC_2395 5646831 180.19 µM -1.19228444587204 0.119719756172492 no 2983 0.116574865637996 4292 6808628 SGTC_2842 9000675 19.48 µM -1.19255059235089 0.119667656195742 no 2984 0.116522712803762 4320 2989072 SGTC_1738 st035555 74 µM -1.19345592406929 0.11949055109543 no 2985 0.116345432075699 4327 5331140 SGTC_3208 9114115 49.47 µM -1.19731152827978 0.118738371246088 no 2986 0.115592576347041 4292 650895 SGTC_1431 4049-0260 9.09 µM -1.1990184270584 0.118406447208656 no 2987 0.115260390269631 4287 3854841 SGTC_91 0417-1751 58.384 µM -1.20107552772922 0.118007295020499 no 2988 0.114860952493193 4385 6795624 SGTC_1809 st050081 57.6 µM -1.20118443209021 0.117986190182475 no 2989 0.11483983345479 4356 5036894 SGTC_191 3914-0123 66.505 µM -1.20424413977658 0.11739433307569 no 2990 0.114247615059847 4300 3144412 SGTC_1200 1643-0193 18.4 µM -1.20523219096231 0.117203658421686 no 2991 0.114056839250528 4306 5403974 SGTC_647 0140-0236 81 µM -1.20556358857826 0.117139754288705 no 2992 0.113992902882217 4301 990837 SGTC_2814 7977482 42.97 µM -1.20613410304245 0.117029798562443 no 2993 0.113882893651708 4299 6456762 SGTC_898 1000-0849 28.3 µM -1.20628015972664 0.117001660698822 no 2994 0.113854742495142 4295 6751807 SGTC_376 3970-0862 59.1 µM -1.20785842494664 0.116697913207439 no 2995 0.113550861872146 4326 3135186 SGTC_988 1497-1057 103 µM -1.20837501555226 0.116598613517204 no 2996 0.113451522780823 4270 3533044 SGTC_1719 st032227 49.2 µM -1.20886220041889 0.116505021149566 no 2997 0.113357895139275 4295 3125804 SGTC_1581 himbacine 57.9 µM -1.20980880070129 0.116323323536917 no 2998 0.113176134214501 4290 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1065 prochlorperazine maleate 2.48 µM -1.21109586883294 0.116076596611211 no 2999 0.11292933225884 4335 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2170 morpholine 200 µM -1.21782634998578 0.114792434464804 no 3000 0.111644984376613 4331 121171 Reacts with secondary amines. SGTC_1870 st057514 26.5 µM -1.21822312240987 0.11471704782706 no 3001 0.111569597574739 4288 5393161 SGTC_3237 9133362 49.47 µM -1.2208922716612 0.114210825790337 no 3002 0.111063405500096 4280 43845137 SGTC_1972 st070201 17.4 µM -1.22098928243885 0.114192457055512 no 3003 0.111045038871428 4313 2829099 SGTC_1985 st071382 65.5 µM -1.22110366350016 0.114170802006294 no 3004 0.11102338639701 4299 6123237 SGTC_2356 9061756 188.97 µM -1.22574147485557 0.113295216614042 no 3005 0.110147988638771 4339 20104043 SGTC_984 1492-0255 2.91 µM -1.22640694395306 0.113169974865756 no 3006 0.110022787106858 4291 1585198 SGTC_690 glyoxal 20.3 µM -1.22732178533999 0.112997962367467 no 3007 0.109850835324492 4102 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2245 6637752 200 µM -1.22872372845229 0.112734725079398 no 3008 0.10958770325978 4354 681890 SGTC_817 1391-0715 46 µM -1.23121289911096 0.112268422883728 no 3009 0.1091216241245 4292 1353946 SGTC_1384 3089-0840 101 µM -1.23223728754674 0.112076922682607 no 3010 0.108930229153831 4305 1069836 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.23313502949933 0.11190928999327 no 3011 0.10876269511113 4213 17037758 SGTC_3063 1327-0034 4 µM -1.23580536225478 0.11141172670997 no 3012 0.108265460653128 4198 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2924 9010168 62.78 µM -1.23712659070389 0.111166128479913 no 3013 0.10802004466638 4351 2993929 SGTC_1519 esterone 74 µM -1.24027302445514 0.110582811115365 no 3014 0.107437213220989 4282 698 A steroid. SGTC_1794 st048918 76.9 µM -1.24059557530892 0.110523137623046 no 3015 0.107377593664282 4256 672303 SGTC_2370 9071495 200 µM -1.2427676311961 0.110121897663679 no 3016 0.106976736813558 4317 21791103 SGTC_471 1-acyl-paf 4 µM -1.24337702105916 0.110009514116836 no 3017 0.106864466968615 4273 16759367 SGTC_1250 0485-0349 40.2 µM -1.24793584623179 0.109171386449731 no 3018 0.106027276001681 4349 6842794 YDL195W SEC31 SGTC_3032 9089427 49.47 µM -1.24833215943055 0.109098742708563 no 3019 0.105954720846732 4319 17173707 SGTC_1141 3253-0389 52.6 µM -1.24861886801008 0.109046211024967 no 3020 0.105902253961553 4316 5402031 SGTC_1973 st070275 50.2 µM -1.24872413232804 0.109026928715688 no 3021 0.105882995592731 4264 17118334 SGTC_2109 5483026 200 µM -1.24894451288739 0.108986567359002 no 3022 0.105842684618213 4339 759335 SGTC_2223 6903751 107.57 µM -1.24987756398694 0.108815803730171 no 3023 0.10567213820395 4290 5598863 SGTC_1798 st045719 60.953 µM -1.25079931189835 0.108647297750168 no 3024 0.105503853004938 4276 3980186 SGTC_2610 ononetin 44.17 µM -1.25233016446225 0.108367855351098 no 3025 0.105224790869226 4304 259632 SGTC_2299 7976368 114.88 µM -1.25638586462326 0.107630027370285 no 3026 0.1044880520371 4351 2979718 SGTC_986 1493-0483 84 µM -1.26239947714198 0.106542681978633 no 3027 0.103402538639308 4280 40079 SGTC_827 3253-0474 693 µM -1.2629159142401 0.106449674008051 no 3028 0.103309700017041 4363 5402065 SGTC_1887 st057648 70.8 µM -1.2703365865362 0.105119712796748 no 3029 0.101982380532542 4340 688672 SGTC_3109 9122853 49.47 µM -1.27279993716587 0.104680891422429 no 3030 0.101544521748619 4368 1234709 SGTC_1943 st076331 65.2 µM -1.27344174393602 0.104566778120887 no 3031 0.101430666212535 4338 24208415 SGTC_2943 9068529 45.32 µM -1.27415015065823 0.104440927998195 no 3032 0.101305103941723 4331 3270634 SGTC_1630 st005209 31.3 µM -1.27422555625312 0.104427538482175 no 3033 0.1012917452719 4331 3367314 SGTC_1347 1493-0251 600 nM -1.27857632493113 0.103657092192812 no 3034 0.100523145717371 4389 3986378 SGTC_2844 9010103 25.97 µM -1.28230579211161 0.102999957605353 no 3035 0.0998676984584653 4340 2480525 SGTC_2217 6934799 96.0675 µM -1.28453927959267 0.102607867302311 no 3036 0.0994766644891544 4330 675606 SGTC_1107 amlodipine 47 µM -1.28630680147227 0.10229834749291 no 3037 0.0991680048644223 3989 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1015 4130-4525 82 µM -1.28772460660333 0.102050559626753 no 3038 0.098920922415311 4363 1363237 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.28924136543785 0.101785961564805 no 3039 0.0986570941664617 4356 5024745 SGTC_279 1273-0055 2.93 µM -1.28992952703187 0.101666076843456 no 3040 0.0985375638714852 4387 2847562 SGTC_1209 2323-2347 50.3 µM -1.29036408926443 0.101590424679499 no 3041 0.0984621371777134 4349 5412760 SGTC_597 k018-0003 82.8 µM -1.29051397951775 0.101564340063455 no 3042 0.098436130628516 4424 6786234 SGTC_2216 7189485 200 µM -1.29133485763353 0.101421573437799 no 3043 0.0982937942386989 4357 731273 SGTC_844 0330-0132 15.3 µM -1.29138554109508 0.10141276339473 no 3044 0.0982850109092871 4410 2828079 SGTC_2478 5763493 32.33 µM -1.29541715906016 0.100713752890867 no 3045 0.0975881809286033 4300 1365576 YLR208W SEC13 SGTC_1760 st045453 10.4495 µM -1.29564882727568 0.100673692790275 no 3046 0.0975482494542974 4400 3323419 YIL048W NEO1 SGTC_1512 0259-0544 12.2 µM -1.30265866515228 0.099467041344356 no 3047 0.0963456598680991 4332 18476 SGTC_1831 st055328 12 µM -1.30320298752842 0.0993737876047484 no 3048 0.0962527352337905 4352 1103068 SGTC_896 0964-0007 44.5 µM -1.30334603932255 0.0993492904673355 no 3049 0.0962283249136334 4339 6756758 SGTC_1751 st044839 27.194 µM -1.30426808129258 0.0991914998167898 no 3050 0.0960710970978561 4410 5291326 SGTC_2080 5212524 12.4 µM -1.30768993296978 0.0986075144654441 no 3051 0.0954892496262422 4321 260183 SGTC_296 1222-0039 74.9 µM -1.30851904033026 0.0984663956117511 no 3052 0.0953486603836213 4383 5984176 SGTC_193 1273-0060 1.558 µM -1.30986257480568 0.0982380323485228 no 3053 0.095121164914144 4204 2847393 YHR072W ERG7 SGTC_1893 st059353 36.1 µM -1.31142983799168 0.0979721319710309 no 3054 0.0948562917767173 4390 3112488 SGTC_2997 9067075 71.4286 µM -1.31402999650134 0.0975321555535619 no 3055 0.0944180549606887 4335 27209819 SGTC_1736 st036774 51 µM -1.31410728344536 0.0975190999353407 no 3056 0.0944050517238662 4423 1272247 SGTC_716 1683-5115 658 µM -1.3149610646414 0.0973749610950008 no 3057 0.0942614941176376 4362 723597 SGTC_2713 st079149 53.4 µM -1.31677383684526 0.0970694397810948 no 3058 0.0939572225704918 4405 3103253 SGTC_3201 9113999 49.47 µM -1.31735971511132 0.0969708475322128 no 3059 0.0938590387872125 4359 16649224 SGTC_1797 st048695 56.8 µM -1.31848191938975 0.0967822070372119 no 3060 0.0936711868656819 4336 592262 YIL048W NEO1 SGTC_1986 st071812 45 µM -1.32027042621833 0.096482119511629 no 3061 0.0933723728975529 4318 11838594 SGTC_3267 9137951 49.47 µM -1.32060312854358 0.0964263720076915 no 3062 0.0933168645730411 4429 16643986 SGTC_2545 solidagenone 89.61 µM -1.32173947704965 0.0962361442655387 no 3063 0.0931274591075905 4267 6708572 An anti ulcer agent SGTC_261 5-fluorouridine 15.376 µM -1.32221314963298 0.0961569317322004 no 3064 0.0930485917741088 4397 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1620 st003704 16.5 µM -1.32606090148504 0.0955152454801689 no 3065 0.092409762768006 4358 2834414 SGTC_2962 9082311 13.18 µM -1.32738236681662 0.0952955945089772 no 3066 0.0921911148240626 4354 16459453 SGTC_2514 salinomycin 42.74 µM -1.32826799675008 0.0951485953914391 no 3067 0.0920447941199697 4430 23682228 A polyether potassium ionophore. SGTC_630 4356-0227 183 µM -1.32891757577759 0.095040882813838 no 3068 0.0919375822909935 4335 779312 SGTC_2225 6654152 15.4 µM -1.33138915241112 0.0946318693087767 no 3069 0.0915304984280167 4307 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1412 3909-8563 178 µM -1.3331255679508 0.0943452922741997 no 3070 0.0912453000617846 4473 23767530 SGTC_2279 7948423 32.93 µM -1.33397469865647 0.0942053854621086 no 3071 0.0911060743226868 4356 1247112 SGTC_2280 7785178 200 µM -1.33606228693527 0.0938620752371511 no 3072 0.0907644576850122 4380 2954328 SGTC_1906 st060206 94.7 µM -1.33625824698014 0.0938298964849474 no 3073 0.090732439304647 4417 5133468 SGTC_1260 0700-1617 7.75 µM -1.34280036571777 0.0927602788940964 no 3074 0.0896683124787838 4371 2853078 SGTC_236 1509-0011 5.31 µM -1.34300890948797 0.0927263315041535 no 3075 0.0896345444661151 4434 3107280 SGTC_2098 5376439 882.5 nM -1.34836122444534 0.0918582066554039 no 3076 0.0887711145484083 4437 2844116 SGTC_1157 4092-0394 27.6 µM -1.35700328024615 0.0904692286356748 no 3077 0.0873900841233348 4456 3659885 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.35924261656353 0.0901118725099649 no 3078 0.0870348605107364 4396 5379071 SGTC_2164 5685496 200 µM -1.36014820360828 0.0899676559590216 no 3079 0.0868915148253625 4326 759046 SGTC_1199 1638-0010 4.46 µM -1.3603004399014 0.0899434288738757 no 3080 0.0868674346178363 4391 3111136 SGTC_1163 k060-0048 49.9 µM -1.36049973871134 0.0899117195261502 no 3081 0.0868359177615555 4422 6809982 SGTC_2802 7925815 54.55 µM -1.36305553598437 0.0895058166979056 no 3082 0.0864325042856562 4386 1262923 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.36327207013424 0.0894714902202013 no 3083 0.0863983904867443 4415 5282362 SGTC_502 l-744,832 89.3 µM -1.36328775874383 0.0894690035347245 no 3084 0.0863959192212895 4423 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_464 bw-b 70c 158 µM -1.36949965238192 0.0884884368759596 no 3085 0.0854215716945548 4424 5353454 SGTC_2491 paeonol 100 µM -1.36984482480417 0.0884341860858908 no 3086 0.0853676730938085 4375 11092 Increases levels of cortical cytochrome oxidase. SGTC_1731 st035964 63 µM -1.3731205621718 0.0879205710983956 no 3087 0.0848574348585763 4332 6739575 SGTC_365 0121-0052 13.6 µM -1.37466647163577 0.0876789563005795 no 3088 0.0846174351945983 4421 3101739 SGTC_1682 st012968 530 nM -1.37481229990648 0.0876561899597045 no 3089 0.0845948219228461 4405 24207270 SGTC_1796 st049173 110.4 µM -1.37513799491037 0.087605359205183 no 3090 0.0845443334769837 4399 94134 SGTC_1815 st051655 58.2 µM -1.37568252202002 0.087520424766622 no 3091 0.0844599727040787 4358 5984156 SGTC_273 hydroxyurea 18.1 mM -1.37667348357114 0.0873660139251911 no 3092 0.084306610220783 4482 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_823 0417-1665 178 µM -1.37695686939048 0.0873218943868445 no 3093 0.0842627915174463 4426 3429856 SGTC_1182 1222-0449 220 µM -1.37834617802393 0.0871058374819347 no 3094 0.0840482161167483 4419 658318 SGTC_2551 apiole 73.87 µM -1.37859561024946 0.087067089594978 no 3095 0.0840097353826404 4340 10659 A possible DNA adduct former. SGTC_392 N-ethylmaleimide 8.33 µM -1.38087994171774 0.0867128302284786 no 3096 0.0836579391285167 4373 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_31 0508-1974 57.237 µM -1.38140887978574 0.0866309551042118 no 3097 0.0835766385699486 4366 6810525 SGTC_1834 st055981 52.8 µM -1.38159213530543 0.08660260218657 no 3098 0.0835484850862077 4411 471719 YDL150W RPC53 SGTC_669 0108-0021 26.2 µM -1.38213890512625 0.0865180483038573 no 3099 0.0834645273752484 4438 17201 SGTC_2458 5808907 16.39 µM -1.38403796699854 0.0862248519320258 no 3100 0.0831734147895477 4547 2731747 SGTC_642 0335-0876 158 µM -1.38453887352386 0.0861476409237269 no 3101 0.083096756805015 4462 6812350 SGTC_1605 st000082 49.1 µM -1.38687332672484 0.085788484456665 no 3102 0.0827401962998944 4380 1114022 SGTC_3141 9094609 49.47 µM -1.38747681306447 0.0856958204461833 no 3103 0.0826482083537221 4388 25236309 YDL196W YDL196W SGTC_1811 st050069 61.5 µM -1.3983862040809 0.0840336037868824 no 3104 0.0809985618659879 4417 3877702 SGTC_2287 7945887 168.79 µM -1.39912019708379 0.0839226437151638 no 3105 0.080888471038897 4451 1245853 SGTC_474 dl-dihydrosphingosine 5 µM -1.39976904584555 0.0838246468245021 no 3106 0.0807912450047958 4426 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3099 9120367 49.47 µM -1.40337687297419 0.0832813167346083 no 3107 0.0802522428459104 4475 24824940 SGTC_1514 1189-1591 158 µM -1.41218054494463 0.0819666230684586 no 3108 0.0789484037090231 4441 767698 YMR146C TIF34 SGTC_2353 9059630 146.67 µM -1.41492048643457 0.0815606624471682 no 3109 0.0785459053201993 4487 4779114 SGTC_2648 atorvastatin 78.68 µM -1.41495744107084 0.0815551974822633 no 3110 0.0785404873218175 4446 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_847 0342-0274 5.54 µM -1.4156931791764 0.0814464517399722 no 3111 0.0784326781385076 4439 18097 SGTC_776 4476-4378 112 µM -1.41681744531792 0.0812804909113364 no 3112 0.0782681539259514 4497 2892008 SGTC_3335 9143315 29.6265 µM -1.41933273866134 0.080910114839806 no 3113 0.0779010158656923 4453 4899691 SGTC_1829 berberine 14.4 µM -1.42085024696459 0.0806872792925516 no 3114 0.0776801497658243 4404 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2849 9019321 12.99 µM -1.42489050614081 0.0800962552052045 no 3115 0.0770944272055444 4463 16489627 SGTC_2529 gangaleoidin 93.61 µM -1.42577197539841 0.0799677466015804 no 3116 0.0769670863932688 4448 4565183 SGTC_83 0170-0301 39.027 µM -1.42970597186827 0.0793961128062953 no 3117 0.0764007127827922 4468 3089716 SGTC_2537 larixol 68.93 µM -1.43131395780754 0.0791633550566258 no 3118 0.0761701277027281 4426 6708759 SGTC_2876 9059903 25.97 µM -1.431967130645 0.0790689552652444 no 3119 0.0760766141908473 4452 6916095 SGTC_2905 7799065 20.05 µM -1.43514853920702 0.0786103807443724 no 3120 0.0756223871329962 4343 1296806 SGTC_406 estrone 100 µM -1.43680348308794 0.07837263228868 no 3121 0.0753869202182642 4444 5870 A steroid. SGTC_2678 equilin 100 µM -1.43806315135064 0.078192034669905 no 3122 0.0752080683434474 4453 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1475 4092-1048 11.7 µM -1.43860642671337 0.0781142432144912 no 3123 0.0751310322311847 4464 2881759 SGTC_2001 4023502 57.655 µM -1.43934140690585 0.0780090950518358 no 3124 0.0750269082751762 4466 108941 YCR052W RSC6 SGTC_1142 3253-1408 9.78 µM -1.44370070286954 0.0773876491190319 no 3125 0.0744115918231561 4476 256655 SGTC_2679 rapamycin 1 nM -1.44382249184561 0.0773703414609507 no 3126 0.0743944567481073 4327 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3015 9080845 49.47 µM -1.44612165750267 0.0770441541656122 no 3127 0.0740715411004246 4523 5296973 SGTC_3346 9158254 43.5805 µM -1.44739436500272 0.0768640425251866 no 3128 0.0738932515406279 4482 17639500 SGTC_1368 1852-0141 284 µM -1.45131544134169 0.0763111498888857 no 3129 0.0733460217397102 4449 2838987 SGTC_804 1595-0054 20.9 µM -1.45240244718663 0.0761584133433388 no 3130 0.0731948681321208 4439 761523 Stimulates phospholipase C. SGTC_1245 0418-0076 17.2 µM -1.45369589406071 0.0759769728152976 no 3131 0.0730153185259091 4485 6790114 SGTC_501 nsc-95397 161 µM -1.46193467309228 0.0748289800913567 no 3132 0.0718795561686971 4482 262093 SGTC_1912 st060209 90.8 µM -1.46503522907333 0.0744003921130305 no 3133 0.0714556532149995 4452 688787 SGTC_2034 5197015 53.07 µM -1.46530253366244 0.0743635306964702 no 3134 0.0714191977880046 4467 780676 SGTC_2649 anisomycin 9.56 µM -1.46756435580234 0.0740521824569284 no 3135 0.0711112980475078 4527 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_423 5-fluorouracil 457 µM -1.4693751818297 0.0738036341183771 no 3136 0.0708655275207104 4418 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2014 4013930 200 µM -1.47025685488546 0.0736828494523493 no 3137 0.0707461007671327 4453 64556 SGTC_2799 7812892 81.82 µM -1.47284347107059 0.0733293682997133 no 3138 0.0703966237994006 4499 20205235 SGTC_1332 1480-0653 17.5 µM -1.47665920743772 0.0728102884586981 no 3139 0.069883506041067 4482 5749438 SGTC_3250 9135583 49.47 µM -1.47671286987746 0.0728030085147262 no 3140 0.0698763104106941 4495 7699353 SGTC_2517 totarol 10 µM -1.47724943412192 0.0727302478770712 no 3141 0.0698043935225055 4486 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_111 0083-0039 52.457 µM -1.47972391245002 0.0723954173052297 no 3142 0.0694734706865899 4449 759313 SGTC_534 k292-0788 63.4 µM -1.48304215883097 0.0719482688292389 no 3143 0.0690316050308788 4534 4146317 SGTC_798 1287-0182 476 µM -1.48498280441892 0.0716877413762636 no 3144 0.068774189634943 4521 1649755 SGTC_3225 9130819 49.47 µM -1.48544523113317 0.0716257684932713 no 3145 0.0687129607394324 4440 4547121 SGTC_282 k297-0036 65.7 µM -1.48621762863245 0.0715223460376206 no 3146 0.0686107830561491 4486 5061378 SGTC_2222 6885208 172.143 µM -1.49245713187846 0.0706910864888894 no 3147 0.0677896736363389 4502 609514 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.49281649918099 0.0706434367535094 no 3148 0.0677426136010039 4369 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2490 carminic acid 95.39 µM -1.49304209632526 0.0706135366734069 no 3149 0.067713083994023 4475 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2159 5658611 73.75 µM -1.49428525739174 0.0704489456691119 no 3150 0.0675505383874509 4480 793844 SGTC_2739 tacrine 100.86 µM -1.49558773376514 0.0702768180362469 no 3151 0.0673805607939868 4550 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1561 5-methoxyflavone 52.9 µM -1.50816137847941 0.0686317507535785 no 3152 0.0657566146465146 4461 94525 SGTC_1423 4048-0112 5.59 µM -1.51054123106022 0.068323753563767 no 3153 0.0654526884456175 4553 X1423 SGTC_2820 7989630 71.43 µM -1.51542249162601 0.0676953661924743 no 3154 0.0648327225506718 4532 2984098 SGTC_2875 9039966 71.43 µM -1.52270737801144 0.066765864638645 no 3155 0.0639159656421367 4489 6463691 SGTC_585 0kpi-0023 191 µM -1.52346608974874 0.0666696288271683 no 3156 0.0638210691433247 4446 64601 SGTC_1842 st055362 61.2 µM -1.52463968530586 0.0665209802079229 no 3157 0.0636744966147045 4466 676032 SGTC_1264 0783-0040 158 µM -1.52800894688038 0.0660956521026173 no 3158 0.0632551583037855 4428 2855798 SGTC_206 4546-0025 72.014 µM -1.52910295427725 0.0659580010735881 no 3159 0.063119461551883 4538 6620745 YIL048W NEO1 SGTC_2190 6049624 200 µM -1.53361921599457 0.0653921027784436 no 3160 0.0625616790525162 4415 2265554 SGTC_1975 st070967 30.8 µM -1.53425361146411 0.0653129140871603 no 3161 0.0624836365519174 4503 261391 SGTC_2438 5259590 200 µM -1.53509557074378 0.0652079310620069 no 3162 0.0623801770647058 4523 1201127 SGTC_2916 7875993 68.79 µM -1.53522804859931 0.0651914244644964 no 3163 0.0623639104296608 4415 1299250 SGTC_2771 fluoxetine 41.05 µM -1.53533296992804 0.0651783536812883 no 3164 0.0623510297412732 4506 3386 A selective serotonin reuptake inhibitor. SGTC_2526 patulin 37.61 µM -1.53709551218927 0.0649590853510535 no 3165 0.0621349609018349 4527 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1706 st031321 9.9705 µM -1.54044642519886 0.0645437960430079 no 3166 0.0617257862086495 4538 6103185 SGTC_1840 st055363 71 µM -1.54114474021182 0.064457511892991 no 3167 0.0616407815306893 4536 676033 SGTC_2142 5622915 118.518 µM -1.54199388508678 0.0643527119040798 no 3168 0.0615375397782704 4525 5322196 SGTC_2768 sulfasalazine 50.2 µM -1.54410711806857 0.0640924751456009 no 3169 0.0612811923743127 4496 5384001 An antioxidant and salicylic acid derivative. SGTC_3264 9137442 49.47 µM -1.5448403405587 0.0640023729621227 no 3170 0.0611924434651646 4494 17015726 SGTC_1758 st042942 75.2445 µM -1.54573124461902 0.0638930266251279 no 3171 0.0610847440485302 4495 669317 SGTC_740 k014-0057 261 µM -1.54693084716875 0.0637460213452425 no 3172 0.0609399608746357 4506 4012779 SGTC_1710 st031758 61.5 µM -1.54865676004618 0.063534981134665 no 3173 0.060732126766473 4543 5394341 SGTC_220 paclitaxel 373.376 µM -1.54884838538185 0.0635115832534287 no 3174 0.0607090855117671 4494 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_226 1,3-diallylurea 8.28947 mM -1.55278234921548 0.0630327179779505 no 3175 0.0602375704590613 4502 74537 YKL182W FAS1 SGTC_1214 0358-0031 63.7 µM -1.55294094235689 0.0630134722195974 no 3176 0.0602186221653387 4533 4301366 SGTC_1113 artemisinin 1.17947 µM -1.553891153458 0.0628982570759091 no 3177 0.0601051911358383 4553 2240 An anti-malaria and mitochondrial poison. SGTC_74 000s-0487 160.283 µM -1.5549526882575 0.0627697378579423 no 3178 0.0599786688021859 4395 677548 SGTC_154 3389-1638 511.116 µM -1.556793019163 0.0625474153965578 no 3179 0.059759817574527 4507 5238686 SGTC_2719 novobiocin 32.65 µM -1.56202133222355 0.0619191539693825 no 3180 0.0591414817704514 4550 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1799 st045822 46.1415 µM -1.56899888631631 0.0610883800199886 no 3181 0.0583240992581244 4517 3674992 SGTC_1413 3910-0535 34.4 µM -1.56913603229269 0.0610721386368343 no 3182 0.0583081227244299 4548 2876951 SGTC_1922 5578187 25 µM -1.56981831580399 0.0609913900095139 no 3183 0.0582286926178518 4525 1350412 SGTC_548 1436-0017 110 µM -1.57111994394393 0.060837573120743 no 3184 0.0580773954197893 4559 9677137 SGTC_1820 st053765 18.6 µM -1.58320975600646 0.0594233423452733 no 3185 0.0566868317773432 4560 3690829 SGTC_109 0132-0036 33.701 µM -1.59019190051321 0.058618408670272 no 3186 0.0558957778237702 4447 67274 A color developer. SGTC_508 roscovitine 141 µM -1.59036431422132 0.0585986408616887 no 3187 0.055876354664949 4600 160355 A CDKinase inhibitor. SGTC_170 4197-0004 226 µM -1.59041849153179 0.058592430332506 no 3188 0.0558702524534001 4554 218692 SGTC_2634 4'-methoxyflavone 100 µM -1.59662013262298 0.0578849240061185 no 3189 0.0551752042068167 4527 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2188 6126565 140.678 µM -1.60369792145243 0.0570856883191811 no 3190 0.0543903271470122 4461 874518 SGTC_2911 7942208 15.64 µM -1.60385515085514 0.0570680328493917 no 3191 0.0543729923168424 4555 1243384 SGTC_1043 0916-0009 19.3 µM -1.61039880530581 0.0563370434292009 no 3192 0.0536554106217657 4556 3101130 SGTC_1038 k292-0204 154 µM -1.61131408842242 0.056235388493431 no 3193 0.0535556408039642 4498 4454212 SGTC_103 0844-0104 51.839 µM -1.61196776936396 0.0561628766860909 no 3194 0.0534844767643782 4374 5375804 SGTC_1120 ficusin 1.78878 µM -1.61587707889558 0.0557307608164205 no 3195 0.0530604461144802 4550 6199 A DNA cross-linker. SGTC_1795 st049545 62.3 µM -1.62412025846474 0.0548282011359521 no 3196 0.0521750725691295 4527 5291882 SGTC_1948 st076329 66.6 µM -1.6250503062308 0.0547270981118705 no 3197 0.0520759200955755 4486 24208413 SGTC_163 TUB2.036 7.546 µM -1.62710275881902 0.0545045029794897 no 3198 0.051857637605035 4511 15992207 YJR013W GPI14 SGTC_1280 0880-0253 10.1 µM -1.63070670591722 0.0541153764023999 no 3199 0.0514761104652097 4543 6836607 SGTC_3161 9100388 49.47 µM -1.63519112918091 0.0536342565557755 no 3200 0.0510044935887786 4629 25236368 SGTC_933 2914-0560 114 µM -1.63562196891526 0.0535882120676567 no 3201 0.0509593648004814 4572 463887 SGTC_2374 9071832 200 µM -1.63576216326832 0.0535732360416172 no 3202 0.0509446868427164 4504 17381698 SGTC_1657 st012939 43.4 µM -1.63782443453628 0.0533533202856949 no 3203 0.0507291614305772 4550 24207257 SGTC_653 0203-0016 55.2 µM -1.63853758775955 0.0532774380046228 no 3204 0.050654799859802 4610 295302 SGTC_2448 5185112 27.17 µM -1.63907747327164 0.0532200489976445 no 3205 0.0505985629371059 4561 5718189 SGTC_1145 3546-0597 10.2 µM -1.639110219964 0.0532165696511187 no 3206 0.0505951534935143 4547 875334 SGTC_3038 9091290 49.47 µM -1.63912509925522 0.0532149887812558 no 3207 0.050593604386708 4546 25236843 SGTC_1653 st012112 65 µM -1.64036519459302 0.0530833640194191 no 3208 0.0504646288120696 4536 720429 SGTC_701 4424-0219 185 µM -1.64117943726252 0.0529970801076727 no 3209 0.050380086422649 4575 2911779 SGTC_2143 5623677 140.463 µM -1.64917381573115 0.052155824452601 no 3210 0.0495560153104642 4544 5375313 SGTC_1874 staurosporine 7.6 µM -1.64957011804846 0.0521143987309821 no 3211 0.0495154454725093 4561 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2033 5192550 145 µM -1.65172190924812 0.0518899267202688 no 3212 0.0492956271147589 4570 182073 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.65357344873417 0.051697392172703 no 3213 0.0491071055758185 4575 75037 A free radical scavenger. SGTC_1806 st050005 60.3 µM -1.66327588515714 0.0506977406505079 no 3214 0.0481286117715084 4612 5194765 SGTC_1984 st072354 53.1 µM -1.66331626606349 0.0506936125666974 no 3215 0.0481245721879492 4474 5762938 SGTC_1103 duloxetine 36.1 µM -1.67048479708443 0.0499650154330908 no 3216 0.0474117424337789 4621 60835 A selective serotonin reuptake inhibitor. SGTC_1404 3909-7820 48.3 µM -1.67446933768684 0.0495636590048072 no 3217 0.0470191978232824 4564 23741373 SGTC_445 e6 berbamine 66 µM -1.67506189976612 0.0495041915532408 no 3218 0.0469610436759884 4571 6610268 A calcium/calmodulin antagonist. SGTC_1753 st043925 64 µM -1.67641689590879 0.0493684228889524 no 3219 0.0468282808561221 4593 670181 SGTC_134 0269-0018 6.916 µM -1.68016890507578 0.048994027784296 no 3220 0.0464622287258055 4520 4378915 SGTC_1328 1441-0025 69.2 µM -1.68325943461868 0.0486873452916321 no 3221 0.0461624397994718 4613 4562601 SGTC_2432 5630864 12.22 µM -1.68906068281583 0.0481158151423715 no 3222 0.0456039007361514 4577 5714970 SGTC_3030 9087619 49.47 µM -1.69073234828426 0.0479521253745066 no 3223 0.0454439665712524 4580 25236973 SGTC_1978 st071761 42 µM -1.69869381513396 0.0471786447106935 no 3224 0.0446884446961683 4600 5147680 SGTC_920 mycophenolic acid 780.421 nM -1.69996859980333 0.0470557295862832 no 3225 0.044568415996891 4575 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1642 st009582 77.7 µM -1.70065373136855 0.0469897751498314 no 3226 0.0445040140824693 4581 6739311 SGTC_3147 9097027 49.47 µM -1.70412632236601 0.0466566241676289 no 3227 0.0441787449959811 4593 25236841 SGTC_566 0958-0068 16.5 µM -1.70947180288409 0.0461475001081381 no 3228 0.0436817952310479 4501 6815365 SGTC_684 1140-0066 328 µM -1.71485621154288 0.0456391889329818 no 3229 0.0431857962972441 4602 6813534 SGTC_2273 7815444 169.05 µM -1.71500679728527 0.0456250379597928 no 3230 0.0431719903553016 4526 2824616 SGTC_385 1494-0393 12.4 µM -1.71921225531833 0.0452312618924337 no 3231 0.0427878650434601 4556 3090647 SGTC_761 k216-0224 480 µM -1.72378389105569 0.0448063055443458 no 3232 0.0423734318789362 4601 1340404 SGTC_2306 7482397 179.52 µM -1.75099749297273 0.0423427654751628 no 3233 0.0399731709297506 4583 891448 SGTC_2772 vinpocetine 57.06 µM -1.75295467996999 0.0421698980905069 no 3234 0.0398048932939949 4601 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2480 5767542 37.17 µM -1.75298341698085 0.0421673641717243 no 3235 0.0398024268015138 4530 2867358 SGTC_2276 7947513 42.08 µM -1.7540463118757 0.0420737287257617 no 3236 0.039711285973391 4534 2105100 SGTC_2277 7947813 106.88 µM -1.75913364307537 0.041627889479049 no 3237 0.0392774058896639 4614 1246798 SGTC_2750 bromebric acid 70.15 µM -1.75962753521488 0.0415848107499613 no 3238 0.0392354898479149 4600 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1952 st077036 64.1 µM -1.76316292008128 0.0412774976145104 no 3239 0.0389365078292699 4630 2937007 SGTC_1470 k295-0292 231 µM -1.76621438092671 0.0410137321231772 no 3240 0.0386799446387522 4659 5045612 SGTC_3242 9133940 49.47 µM -1.7730195578662 0.0404304213834914 no 3241 0.038112733061204 4616 17248444 SGTC_2078 5212016 200 µM -1.78140328852338 0.0397210839614339 no 3242 0.0374232956995959 4534 1899708 SGTC_3108 9121785 49.47 µM -1.78493708491811 0.0394251408159978 no 3243 0.0371357612489218 4510 17140271 SGTC_3146 9095609 49.47 µM -1.78578773441936 0.0393541704061492 no 3244 0.0370668167206879 4642 17173999 SGTC_1756 st041558 35.5 µM -1.78805366741094 0.0391656288269296 no 3245 0.0368836748668377 4681 3955792 SGTC_621 3584-0052 32.1 µM -1.79536557158463 0.0385622356728321 no 3246 0.0362977370215972 4651 2273927 SGTC_2431 5490079 200 µM -1.80023147164436 0.0381649058769945 no 3247 0.0359120481966678 4640 5722345 SGTC_2415 st077333 57.7 µM -1.80287438025068 0.0379504997360409 no 3248 0.0357039726992206 4607 2766255 SGTC_2809 7964133 12.99 µM -1.80948521226923 0.0374184967664539 no 3249 0.0351878277394922 4609 1253665 SGTC_1232 0279-0259 161 µM -1.8100658080827 0.0373720660697247 no 3250 0.035142791267915 4622 1560000 SGTC_625 k213-0058 121 µM -1.81345129693262 0.0371022623345003 no 3251 0.0348811219341057 4678 3655420 SGTC_874 0599-0792 117 µM -1.82923955498982 0.0358649758909935 no 3252 0.0336818646242279 4618 765305 SGTC_115 0527-0192 112.043 µM -1.84103178503324 0.0349630718845871 no 3253 0.0328084504722025 4598 4233931 SGTC_1498 4478-3555 97.6 µM -1.84119192722656 0.0349509530617707 no 3254 0.032796718976507 4653 3437919 SGTC_1426 4048-4480 71.7 µM -1.84459300514536 0.0346943883123534 no 3255 0.0325483826466794 4661 14224343 SGTC_1927 st060202 13.8 µM -1.84616477800144 0.0345763432108963 no 3256 0.0324341417261252 4588 688887 SGTC_1685 st024049 53.0905 µM -1.84632410185086 0.0345643959250079 no 3257 0.0324225801046093 4664 1941139 SGTC_3135 9127742 49.47 µM -1.84638810441888 0.0345595974917954 no 3258 0.0324179366006484 4672 3643468 SGTC_2751 anetholtrithion 17.25 µM -1.84798832776223 0.0344398024979298 no 3259 0.0323020157009438 4589 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.85086535485084 0.0342252823790546 no 3260 0.032094463005794 4661 1273210 SGTC_2081 5214970 32.255 µM -1.85201202235556 0.0341400899545033 no 3261 0.0320120482757556 4595 2063512 SGTC_112 phenothiazine 287.218 µM -1.85434889601863 0.033967010049258 no 3262 0.0318446304920585 4604 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1930 st074634 34.3 µM -1.85446272290427 0.0339585979577904 no 3263 0.0318364942389962 4566 684253 YOR116C RPO31 SGTC_894 0960-0238 55.9 µM -1.86808877292375 0.0329639088231472 no 3264 0.0308748490958327 4641 6741907 YDL195W SEC31 SGTC_1888 azatryptophan 97.5 µM -1.87064727056607 0.0327798448993084 no 3265 0.0306969939816553 4656 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1924 st058459 75.1 µM -1.88018384244247 0.0321012137756879 no 3266 0.0300415134463223 4624 688683 SGTC_1647 st011722 22.4 µM -1.90006899155715 0.0307234472859846 no 3267 0.0287120331754619 4658 2854783 SGTC_537 1334-0398 209 µM -1.90178226637643 0.0306070673234691 no 3268 0.0285998127995562 4670 5846986 SGTC_917 harmaline 728.087 nM -1.9125615893349 0.0298831925856047 no 3269 0.0279021004641443 4587 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2958 9077254 16.72 µM -1.92228354478133 0.029242558690708 no 3270 0.0272850446922898 4666 16457351 SGTC_2819 7996655 46.38 µM -1.92353693625705 0.0291608020401677 no 3271 0.0272063262012645 4642 6456960 SGTC_1224 0823-0416 294 µM -1.92376391556963 0.0291460168814295 no 3272 0.0271920911848855 4676 3598164 SGTC_374 0880-0231 82.3 µM -1.93989897187101 0.0281108434508977 no 3273 0.0261959845334134 4545 6833587 SGTC_131 0141-0277 33.849 µM -1.94516935467748 0.0277794178826581 no 3274 0.0258772994338138 4621 1547771 SGTC_2873 9040596 71.43 µM -1.95130044670319 0.0273979702654683 no 3275 0.0255106579860702 4643 6463863 SGTC_1810 st050138 53 µM -1.9553061625281 0.0271511203101467 no 3276 0.0252734721326363 4694 3444541 SGTC_605 1315-0399 119 µM -1.95938956602972 0.0269013957034395 no 3277 0.0250335908334839 4710 24020461 SGTC_2724 maprotiline 69.64 µM -1.96665617425216 0.0264617415473627 no 3278 0.024611431306872 4616 4011 A tricyclic antidepressant. SGTC_587 k089-0003 57 µM -1.96956266469413 0.0262875781750257 no 3279 0.0244442570482251 4627 9659696 SGTC_1659 st012954 42.1 µM -1.97385366031308 0.0260322046075816 no 3280 0.0241991926055881 4678 24207262 SGTC_1477 0139-0234 16 µM -1.97563073035341 0.0259270536863551 no 3281 0.0240983077602085 4686 620880 SGTC_158 k038-0087 26.446 µM -1.98656806182934 0.0252876769079844 no 3282 0.0234851417233183 4602 X158 SGTC_2487 5918373 44.05 µM -1.98678480795773 0.0252751410237484 no 3283 0.0234731244314995 4695 2876279 SGTC_1487 3970-0795 2.82 µM -1.98692006922114 0.025267320595346 no 3284 0.0234656276158116 4707 3765103 SGTC_2372 9071633 200 µM -2.01834911138711 0.0235043420571636 no 3285 0.021777457639877 4710 21321366 SGTC_3169 9102970 49.47 µM -2.01953321192993 0.0234399967750632 no 3286 0.0217159144828401 4733 17027839 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.02011121632119 0.0234086412725378 no 3287 0.0216859263393272 4680 5377381 SGTC_322 k048-0136 19.3 µM -2.04173394693649 0.0222607576362822 no 3288 0.0205889647418464 4721 6823282 SGTC_479 n-linoleoylglycine 10 µM -2.0434674016734 0.0221708264645766 no 3289 0.0205030955802841 4710 6433346 An anti-infammatory. SGTC_104 0074-0074 590.992 µM -2.05084864067309 0.0217913146154866 no 3290 0.0201408445163633 4630 3943124 SGTC_3254 9136651 49.47 µM -2.05550283649037 0.021554847827786 no 3291 0.0199152309888318 4666 16454030 SGTC_1999 st074831 12.5 µM -2.05592684148917 0.0215334135000961 no 3292 0.0198947842175573 4677 17112523 SGTC_1496 4469-0713 57.4 µM -2.07186649686684 0.0207406000210831 no 3293 0.0191389465892805 4728 746691 SGTC_3048 9093155 49.47 µM -2.0749304394318 0.0205910712739513 no 3294 0.0189964910510056 4711 25236002 SGTC_396 dithiazanine 1.25 µM -2.08117226030672 0.0202892771009444 no 3295 0.0187090708175608 4684 10578 An antihelmenthic. SGTC_3315 9136395 68.55 µM -2.08458908134421 0.0201256666197103 no 3296 0.0185533082222967 4703 16876844 SGTC_5 0352-0601 109.883 µM -2.08827346666298 0.019950499258666 no 3297 0.0183865867453723 4621 762456 SGTC_1451 4152-0210 104 µM -2.08930626998816 0.0199016292598621 no 3298 0.0183400811740701 4714 659563 SGTC_3337 9144342 33.5465 µM -2.10922954799837 0.0189785984728726 no 3299 0.0174623862980248 4695 17682949 SGTC_1017 4239-0030 168 µM -2.12326828370035 0.0183502819579337 no 3300 0.016865688419935 4714 1149593 SGTC_2709 st078560 56 µM -2.14113379789519 0.0175763933017161 no 3301 0.0161316249173354 4686 17250903 SGTC_2347 9049783 174.81 µM -2.16876047750462 0.0164345805269717 no 3302 0.0150504366194492 4691 6467988 YPL169C MEX67 SGTC_1499 4480-0877 67.3 µM -2.1789973617573 0.0160279217458508 no 3303 0.0146659321025744 4737 2861909 SGTC_714 4296-0578 26.1 µM -2.19404166899411 0.0154459541717871 no 3304 0.014116207039569 4750 1589775 SGTC_82 0054-0107 293.755 µM -2.19668173321474 0.0153457206876386 no 3305 0.0140215921746121 4707 3104697 SGTC_961 1252-1571 372 µM -2.2076571260194 0.014934991040927 no 3306 0.0136340918378746 4724 6813498 SGTC_3168 9103419 49.47 µM -2.21086325820742 0.0148168068322547 no 3307 0.0135226538365294 4752 16649256 SGTC_735 3076-0345 636 µM -2.2224167508164 0.0143975702604569 no 3308 0.0131275771700479 4726 2888990 SGTC_3255 9139072 49.47 µM -2.22345511034434 0.0143603969334616 no 3309 0.0130925635567262 4728 17646060 SGTC_378 3970-0959 8.33 µM -2.22703904785981 0.0142327260165296 no 3310 0.0129723321061597 4718 6615653 SGTC_1813 st051246 8.6015 µM -2.22915194450812 0.0141579171984442 no 3311 0.0129018983571039 4719 5291959 SGTC_182 3448-4371 550.524 µM -2.23340475386835 0.0140083697531393 no 3312 0.0127611324892173 4679 3491403 SGTC_1322 1348-1070 12 µM -2.23378506649093 0.0139950628617146 no 3313 0.0127486093009782 4723 6758089 SGTC_2989 9073649 71.4286 µM -2.23410562967575 0.0139838550286111 no 3314 0.0127380618419952 4686 21367202 SGTC_1568 digitonin 820 nM -2.23848291336182 0.0138315847758696 no 3315 0.0125947902212145 4699 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2822 7994718 71.43 µM -2.25645390102444 0.0132213304789522 no 3316 0.0120211096194963 4732 1018011 SGTC_1641 st009299 47.1 µM -2.27123635241773 0.0127369268665824 no 3317 0.0115663369416595 4733 4046054 SGTC_778 3456-2434 196 µM -2.28461022171633 0.0123119882121072 no 3318 0.0111678465194737 4674 5539063 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.28658529652375 0.0122502851469106 no 3319 0.0111100201350816 4742 2333 A French combination drug. SGTC_2969 9091408 28.7 µM -2.29587482183774 0.0119636531436114 no 3320 0.0108415198732305 4684 4286311 SGTC_2404 5161160 200 µM -2.30422632043939 0.0117109477908401 no 3321 0.0106049712232693 4705 2831543 SGTC_2761 levamisole 97.89 µM -2.31763132739135 0.0113150144521447 no 3322 0.0102346830613283 4736 26879 An alkaline phosphatase inhibitor. SGTC_2546 rhodinyl acetate 100 µM -2.32650964027432 0.0110592326254061 no 3323 0.00999568939450465 4726 6708682 SGTC_2379 9035213 200 µM -2.33905580904889 0.0107063620603132 no 3324 0.00966627266652593 4734 646551 SGTC_130 0136-0219 337.655 µM -2.34530363941897 0.0105343232455775 no 3325 0.00950579490521067 4695 234244 SGTC_2942 9052777 62.25 µM -2.36451956614194 0.0100202060531248 no 3326 0.00902673684405262 4739 6469503 SGTC_2139 5578692 56.4705 µM -2.36600707574549 0.00998133716150565 no 3327 0.00899055037755592 4739 650991 YMR113W FOL3 SGTC_1058 3448-5425 97.3 µM -2.37054509418236 0.00986357001688819 no 3328 0.00888093854365995 4724 7279705 SGTC_1428 4049-0204 61.7 µM -2.40964115608635 0.00889824398631322 no 3329 0.00798410883110142 4761 X1428 SGTC_3136 9095672 49.47 µM -2.41476288619008 0.0087781253244884 no 3330 0.00787272802560356 4685 17217380 SGTC_3145 9085516 49.47 µM -2.41987663219492 0.00865961441603159 no 3331 0.0077628867007471 4728 25236195 SGTC_2794 7785382 27.27 µM -2.50803790643436 0.00682606235499566 no 3332 0.0060701821305992 4745 2205081 SGTC_1853 st056710 91.2 µM -2.51716685910443 0.00665736543738213 no 3333 0.00591513939333968 4775 269167 SGTC_611 3453-1652 23.7 µM -2.52796542082356 0.00646258155372586 no 3334 0.00573628253886769 4758 1560575 SGTC_533 1222-0222 6.71 µM -2.53581123918684 0.00632423859965164 no 3335 0.00560935935369726 4771 3982874 SGTC_2322 7413319 38.22 µM -2.56617468174012 0.00581323739799299 no 3336 0.00514135149427372 4715 1840400 SGTC_3182 9108849 49.47 µM -2.56775303935764 0.00578770557060469 no 3337 0.00511800258154192 4754 17133045 SGTC_2006 4011487 200 µM -2.57836704948018 0.00561858075024559 no 3338 0.0049634245587054 4725 45595294 SGTC_1494 4358-1428 177 µM -2.58106181327628 0.00557634683112224 no 3339 0.00492484719243806 4788 1564571 SGTC_254 nsc-64875 3.808 µM -2.59610819518507 0.00534567354705024 no 3340 0.00471431850718964 4770 56993 SGTC_1944 st076371 56.9 µM -2.59754486597355 0.005324098296693 no 3341 0.00469464266282054 4759 24208455 SGTC_1852 st056254 31.4 µM -2.59885988989296 0.00530441779743038 no 3342 0.00467669707614749 4771 442583 SGTC_427 1354-0053 47.3 µM -2.618785901888 0.00501402495635553 no 3343 0.00441216557115096 4757 6813657 SGTC_2722 naftopidil 47.16 µM -2.63692869649219 0.00476202511500416 no 3344 0.00418302074392226 4746 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3234 9132280 49.47 µM -2.65301929339276 0.0045480461233453 no 3345 0.00398876554218451 4784 17612295 SGTC_2721 ifenprodil 61.44 µM -2.67715556398472 0.00424315239749647 no 3346 0.00371250757831223 4766 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_851 0394-0702 453 µM -2.68894290943364 0.00410100341255256 no 3347 0.00358393384184754 4772 762646 SGTC_2823 7987624 58.44 µM -2.75987555242308 0.00333206577600101 no 3348 0.00289116918512854 4729 2239440 SGTC_162 k030-0015 37.8 µM -2.78559425035733 0.0030870286853896 no 3349 0.00267148523672935 4781 1809920 YMR134W ERG29 SGTC_1703 st026983 48.3 µM -2.82446470419953 0.00274739916808526 no 3350 0.00236798320811561 4790 1104023 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.93834639025649 0.00193762484420608 no 3351 0.001649840639724 4765 6708514 SGTC_204 PMA1.184 62.41 µM -2.9597628124039 0.00181213690525342 no 3352 0.00153937988130394 4786 2252213 YGL008C PMA1 SGTC_2564 betulinic acid 100 µM -2.99990882842409 0.00159662802783106 no 3353 0.00135030214549648 4750 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1955 wogonin 32.4 µM -3.06510036545304 0.00129593154910395 no 3354 0.00108798481364449 4770 5281703 A flavanone. SGTC_916 4466-0038 42 nM -3.25267413839598 0.000696027496790158 yes 3355 0.00057162260369295 4789 5722064 YGL116W CDC20 SGTC_358 0075-0058 9.45 µM -4.18964803993456 1.93710283183135e-05 yes 3356 1.39693730827307e-05 4797 1069125