SGTCid condition conc unit SIL1|YOL031C.score SIL1|YOL031C.strain.pval SIL1|YOL031C.strain.significant SIL1|YOL031C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_426 0988-0037 14.6 µM 6.73913034240577 8.37321305868237e-13 yes 1 7.96687097498382e-12 9 5383008 SGTC_1929 genistein trimethyl ether 50.5 µM 5.5626167044755 2.80011247807524e-09 yes 2 1.32879592495654e-08 3 136420 SGTC_2792 7535235 81.82 µM 5.30151992837466 1.38721119210124e-08 yes 3 5.74212545098444e-08 15 1281891 SGTC_2921 7974240 10.71 µM 5.09558792120313 4.65627562880904e-08 yes 4 1.7383031134538e-07 23 2979074 YDR527W RBA50 SGTC_1068 loratadine 26.9 µM 5.04311361778637 6.29381553408618e-08 yes 5 2.29008551394748e-07 10 3957 A H1 histamine antagonist. SGTC_513 4245-1575 41.7 µM 4.87219690803783 1.64586164526875e-07 yes 6 5.51820449589083e-07 79 719745 SGTC_538 2922-0838 53.3 µM 4.74695741533674 3.2640947656867e-07 yes 7 1.03249703452289e-06 16 777039 SGTC_2336 9001819 198.65 µM 4.49715694056006 1.21721501450094e-06 yes 8 3.44340772445219e-06 32 2989602 SGTC_779 1360-0071 233 µM 4.47954988849897 1.33222207655173e-06 yes 9 3.7400303260525e-06 17 7566 SGTC_2019 4016004 108 µM 4.41631564581359 1.83748082440596e-06 yes 10 5.01987245213906e-06 15 45595336 SGTC_450 aminopyrene 156 nM 4.3851291064401 2.14991328759993e-06 yes 11 5.79585034342237e-06 23 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_868 0527-0199 213 µM 4.21481251145023 4.97759815739049e-06 yes 12 1.24992887985984e-05 22 2849450 SGTC_2373 9071805 200 µM 4.15469131984397 6.64597631127808e-06 yes 13 1.62863487256269e-05 9 10149009 SGTC_3131 9127911 49.47 µM 4.13687548864821 7.2350806084577e-06 yes 14 1.76033511363625e-05 25 45595681 SGTC_255 tunicamycin 200.472 nM 4.07844482431503 9.53671427055908e-06 yes 15 2.26689794792242e-05 69 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 3.80842517090549 3.26263127858172e-05 yes 16 6.9927327221819e-05 29 2333 A French combination drug. SGTC_2833 9001315 45.46 µM 3.7392776131522 4.41610572837384e-05 yes 17 9.22749152400738e-05 65 2989378 SGTC_1674 st016616 23.6 µM 3.60282312957667 7.90929993587432e-05 yes 18 0.00015738986274601 39 625830 SGTC_641 4092-0595 30 µM 3.58084487396439 8.67196580021434e-05 yes 19 0.000171242478781616 19 786260 SGTC_2428 5615643 7.78 µM 3.55032106463831 9.84646873085807e-05 yes 20 0.000192380797876397 39 2253075 SGTC_323 4013-0906 34.3 µM 3.53583847562369 0.000104545826696805 yes 21 0.000203241573737123 14 2910086 SGTC_686 1319-0111 510 µM 3.5211849209771 0.000111056494182902 yes 22 0.000214811448653056 41 4562600 SGTC_249 wiskostatin 11.211 µM 3.49250050105676 0.000124917605233136 yes 23 0.000239260349114653 25 2775510 A n-wasp and actin depolymerizer. SGTC_2055 5235184 200 µM 3.49072053969457 0.000125829104411807 yes 24 0.000240859923952508 52 2836034 SGTC_3088 9117578 49.47 µM 3.42613485269984 0.000163450026054248 yes 25 0.00030611816824355 15 678341 SGTC_2799 7812892 81.82 µM 3.28360028633841 0.000286727857480313 yes 26 0.000512450861361466 53 20205235 SGTC_814 3342-0569 96 µM 3.24860272864035 0.00032810265395732 yes 27 0.000579866619309608 46 4346283 SGTC_1261 0712-0010 12.7 µM 3.22238623625325 0.000362662569773469 yes 28 0.000635638192314379 53 2840123 SGTC_2318 6029776 164 µM 3.19102433278093 0.000408440141304234 yes 29 0.000708846699452423 64 818325 SGTC_520 3584-0023 682 µM 3.18425574866992 0.000418998753844198 yes 30 0.000725633646820083 59 1340790 SGTC_505 gw-5074 63.9 µM 3.17871367360931 0.000427832004063624 yes 31 0.000739650703556201 90 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_563 tetrahydrosecaminediol 614 µM 3.17671945158899 0.000431052527323845 yes 32 0.00074475524685856 40 334274 A psychoactive constituent of the cannabis plant. SGTC_1649 st011737 51.3 µM 3.17249473324105 0.000437949530189213 yes 33 0.00075567650301923 40 1761035 SGTC_2774 tamoxifen 10.92 µM 3.14212293954634 0.000490625537205971 yes 34 0.000838637966955463 38 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2943 9068529 45.32 µM 3.13244898176967 0.000508598408952705 yes 35 0.000866772763917812 59 3270634 SGTC_1087 pterostilbene 9.05 µM 3.11121778724584 0.000550199547303139 yes 36 0.000931587351755173 69 5281727 Similar to reservatol, lowers cholesterol. SGTC_3276 9139060 49.47 µM 3.09857766273012 0.00057643909917181 yes 37 0.000972259989037005 21 4870619 SGTC_3108 9121785 49.47 µM 3.09629339250478 0.000581302644184 yes 38 0.000979781836548297 46 17140271 SGTC_2636 apigenin dimethyl ether 100 µM 3.06559627590002 0.000650447392341312 yes 39 0.00108618212949332 93 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1705 st027868 56.3335 µM 3.05113619283488 0.00068558155817289 yes 40 0.00113988569907868 38 292948 SGTC_1064 honokiol 6.76 µM 2.98448006809171 0.00087131339191103 yes 41 0.00142030353851855 68 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1267 0828-0272 9.49 µM 2.96584784599305 0.000930946491923907 yes 42 0.00150924891923747 63 745334 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.95210806782296 0.000977298357284911 yes 43 0.00157806225885115 132 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1102 cgs 12066b 26.1 µM 2.91853258857033 0.00109961985808806 no 44 0.00175841556507081 38 6438352 A 5-HT1B full agonist. SGTC_831 k061-1017 217 µM 2.91090742143407 0.00112928690400949 no 45 0.00180190390231001 139 1240153 SGTC_1702 st027038 51 µM 2.89009324149091 0.00121403990172426 no 46 0.00192563788340165 59 5521182 SGTC_2225 6654152 15.4 µM 2.86226366956572 0.0013364578031805 no 47 0.00210313410938787 44 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_953 1188-0045 9.7 µM 2.85026773101424 0.00139262462696258 no 48 0.00218412210397083 84 6144426 SGTC_2193 5925765 200 µM 2.82898048384324 0.00149762904866724 no 49 0.00233482732322188 29 877370 SGTC_2219 9098279 200 µM 2.77875501514328 0.00177459430790347 no 50 0.00272838310942451 39 902349 SGTC_1708 st033234 31.827 µM 2.77014430354549 0.00182650874219679 no 51 0.00280157311995351 62 674664 SGTC_2456 5770359 74.46 µM 2.75380442087337 0.00192883596106174 no 52 0.00294534792242003 73 3118787 SGTC_2722 naftopidil 47.16 µM 2.75179267614543 0.00194178804537453 no 53 0.00296350154805167 61 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_876 0720-0963 56.8 µM 2.74375165522147 0.0019943507601553 no 54 0.00303707354749862 67 765861 SGTC_49 0717-0965 32.132 µM 2.72298526542207 0.00213612613883853 no 55 0.00323474716111879 89 5889349 YGL099W LSG1 SGTC_1500 4488-1866 171 µM 2.69763283373462 0.00232157048762353 no 56 0.0034917208646234 84 2900003 SGTC_3110 9122132 49.47 µM 2.69740378829565 0.00232331035340678 no 57 0.00349412377189808 72 918317 SGTC_3136 9095672 49.47 µM 2.69428677802447 0.00234710530679064 no 58 0.00352697216027487 88 17217380 SGTC_2553 4-methylesculetin 85.09 µM 2.68155293594618 0.0024466228252782 no 59 0.0036640659658115 99 5319502 SGTC_359 0081-0058 15.9 µM 2.66931599733018 0.00254583743622222 no 60 0.00380029526731338 132 3494159 SGTC_875 0709-0210 25.7 µM 2.66043207288586 0.00262012967083647 no 61 0.00390202335029077 104 6251364 SGTC_2275 7947463 200 µM 2.64101156444297 0.00278939741272341 no 62 0.00413294489250889 92 1225414 SGTC_946 3434-1334 87.4 µM 2.63620037248953 0.00283282823023691 no 63 0.00419201037071355 108 4047976 SGTC_2706 st078239 82.5 µM 2.61576887882878 0.00302413888212958 no 64 0.00445133979982274 84 15434492 SGTC_530 4358-1714 28 µM 2.60139861397122 0.0031655856943658 no 65 0.00464222519843582 141 1564641 SGTC_1789 tunicamycin 25 nM 2.58390321844816 0.00334581411737547 no 66 0.00488446013435491 139 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2580 diallyl disulphide 81.36 µM 2.58237638559459 0.00336197220765596 no 67 0.0049061253333007 103 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1072 oxiconazole 14.9 nM 2.57585736984827 0.0034317532248261 no 68 0.00499959418319271 139 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_527 4476-4215 268 µM 2.57454811269395 0.00344592373611627 no 69 0.0050185562876886 131 4418754 SGTC_813 k007-0158 173 µM 2.57191459748002 0.00347458643563754 no 70 0.00505689185454648 148 6523916 SGTC_882 0843-0131 351 µM 2.56781639857552 0.00351961655730637 no 71 0.00511706727159481 104 5425421 SGTC_879 0831-1030 162 µM 2.56614204388228 0.00353816429778155 no 72 0.00514183531056576 167 1549252 SGTC_827 3253-0474 693 µM 2.56166959072038 0.00358813914985134 no 73 0.00520851843640448 105 5402065 SGTC_1690 st023502 41.2 µM 2.54489652470637 0.00378125218547808 no 74 0.00546550624398799 81 24207482 SGTC_3320 9137005 35.139 µM 2.52458129671806 0.00402759182377815 no 75 0.00579181045499811 97 4908713 SGTC_1476 4112-3294 3.34 µM 2.51849244701272 0.00410417264271386 no 76 0.00589292056348093 105 704369 SGTC_1813 st051246 8.6015 µM 2.5166427781094 0.0041276930152715 no 77 0.00592394424450102 81 5291959 SGTC_2190 6049624 200 µM 2.51373257228623 0.00416494338935067 no 78 0.0059730490996544 59 2265554 SGTC_1396 3511-0007 98.6 µM 2.51294764205937 0.00417504178650486 no 79 0.00598635512793841 101 X1396 SGTC_2243 6634756 200 µM 2.50978409122824 0.00421596434732866 no 80 0.00604024996997053 95 885676 SGTC_1470 k295-0292 231 µM 2.49242508194609 0.00444696429223814 no 81 0.0063437046552899 98 5045612 SGTC_2131 toluylene red 5.2905 µM 2.49229067935237 0.00444879607749135 no 82 0.00634610587613763 136 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3019 9081971 49.47 µM 2.46016091554891 0.0049065224960456 no 83 0.00694373667914682 92 16451803 SGTC_459 nigericin 15.3 µM 2.45088451744097 0.00504626169198939 no 84 0.00712528325009903 172 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1811 st050069 61.5 µM 2.4411305627197 0.00519700664371613 no 85 0.00732068014938184 64 3877702 SGTC_634 1611-4317 11.2 µM 2.42681953977961 0.00542543379181941 no 86 0.00761591512489156 127 2843522 SGTC_1688 st021091 57.6 µM 2.41719499844025 0.00558403416969857 no 87 0.00782031784118382 74 3656366 SGTC_1048 3161-0300 24.5 µM 2.41432742720159 0.00563207777410073 no 88 0.00788214437964164 126 2165101 SGTC_65 0798-0905 34.986 µM 2.41351391203828 0.00564577416611434 no 89 0.00789976235426623 250 3602145 SGTC_2950 9072895 21.46 µM 2.40527251823011 0.00578620301544028 no 90 0.00808020482278117 184 17332245 SGTC_1482 3346-2049 8.48 µM 2.39355433116004 0.00599121005046659 no 91 0.00834300492029388 135 3826804 SGTC_1450 4112-4260 37.6 µM 2.38555589803496 0.00613481354618091 no 92 0.00852666527270266 127 1633175 SGTC_1249 0481-0015 10.2 µM 2.38124801285782 0.00621341377325907 no 93 0.0086270454780522 133 4227577 SGTC_2377 9073351 62.6 µM 2.37832244918384 0.00626729988396957 no 94 0.00869580510170241 141 7337946 YHR072W ERG7 SGTC_1112 tnp00069 1.16933 µM 2.36700815263762 0.00647961323970035 no 95 0.00896626889302248 144 145826 SGTC_2325 6158266 200 µM 2.36249989313154 0.00656596802513501 no 96 0.00907607333686192 134 3623240 SGTC_418 lividomycin a 100 µM 2.35826157833146 0.00664807858636144 no 97 0.00918037499878572 122 72394 An antibiotic. SGTC_1695 st026914 34.495 µM 2.35110093110663 0.00678886830458497 no 98 0.00935897790145283 135 3289191 SGTC_1467 k284-1082 293 µM 2.35029987367083 0.006804781038318 no 99 0.00937914591872951 137 3334705 SGTC_2054 5233173 129 µM 2.33023734592529 0.00721420990856975 no 100 0.00989680507456952 220 6889 SGTC_2821 7996764 71.43 µM 2.32887930961556 0.0072426934229465 no 101 0.00993273016147865 190 2987135 SGTC_859 0439-0102 54.6 µM 2.32101780594589 0.00740953772406779 no 102 0.0101429414344471 140 610143 SGTC_786 4544-0069 423 µM 2.31748043375805 0.00748570967938651 no 103 0.0102387876437546 173 748821 YLR208W SEC13 SGTC_208 k072-0098 12.366 µM 2.3149207336947 0.00754125832298391 no 104 0.0103086352247874 216 5948901 SGTC_3061 glucosamine 200 µM 2.31490736356144 0.00754154942191491 no 105 0.0103090011491227 103 91431 and experimental redox chemotherapeutic SGTC_1144 3486-0183 12.5 µM 2.31364131990175 0.00756915901801437 no 106 0.0103437025820816 166 6744069 SGTC_2439 5492030 7.2 µM 2.31157556609166 0.00761439965396812 no 107 0.0104005422132694 118 5722370 SGTC_2320 7373003 200 µM 2.30935307719329 0.00766333854735176 no 108 0.0104619982851436 139 5415828 SGTC_2521 angolensin 13.4 µM 2.27798564141857 0.00838416539760507 no 109 0.0113637165492388 123 821428 A flavenoid. SGTC_356 1634-0012 32.5 µM 2.27438093199847 0.00847070018532138 no 110 0.01147154645025 160 735457 SGTC_2791 5663188 71.43 µM 2.26669778373086 0.00865776199539964 no 111 0.011704346952274 158 54690634 SGTC_863 0466-0191 129 µM 2.26116076454242 0.00879480885205739 no 112 0.0118746518658745 210 765160 YPR165W RHO1 SGTC_2427 5545055 42.75 µM 2.24811043588801 0.00912536448241688 no 113 0.012284574397681 165 5372858 SGTC_458 nppb 133 µM 2.24535324048553 0.00919657804501563 no 114 0.012372732344524 127 4549 A chloride channel blocker. SGTC_1498 4478-3555 97.6 µM 2.24500537688898 0.00920559722510845 no 115 0.0123838936939069 78 3437919 SGTC_2008 4012253 172 µM 2.243260532067 0.00925095332515883 no 116 0.012440009444006 191 603940 SGTC_3122 9126309 49.47 µM 2.2322868801912 0.00954071410455131 no 117 0.0127980042183894 123 17591206 SGTC_2420 aureobasidin a 50 nM 2.22843029529758 0.00964441571080593 no 118 0.0129259173716076 214 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_319 1348-1596 45.5 µM 2.20642035821598 0.0102553088442044 no 119 0.013677290449405 167 5380505 SGTC_2005 4024620 188 µM 2.20476047270191 0.0103027188568042 no 120 0.0137354535580466 164 236743 SGTC_624 k048-0052 28 µM 2.20452079944316 0.0103095802224367 no 121 0.0137438694168847 164 6835531 SGTC_1468 k284-1086 134 µM 2.20240087554479 0.0103704430779933 no 122 0.0138185020481164 233 15996457 SGTC_2396 5342950 42.78 µM 2.2023910549294 0.010370725754446 no 123 0.0138188485979193 222 1886677 SGTC_2657 nystatin 74.44 µM 2.19041351394063 0.01072052642444 no 124 0.0142471304103481 163 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1103 duloxetine 36.1 µM 2.1809041936234 0.0110055161678903 no 125 0.0145952517402509 209 60835 A selective serotonin reuptake inhibitor. SGTC_610 4215-0184 155 µM 2.17885283898084 0.0110678513736293 no 126 0.014671301100533 179 5605015 SGTC_1190 1486-1332 13 µM 2.16969093468869 0.0113500202740549 no 127 0.0150151336323903 172 4150046 SGTC_135 0933-0004 26.348 µM 2.16884026557399 0.0113765336452681 no 128 0.0150474065427616 190 21230617 YGL099W LSG1 SGTC_1062 mesoridazine 14.2 µM 2.1543856715787 0.011835345293893 no 129 0.0156049696489488 190 4078 A neuroleptic. SGTC_1443 4112-3303 14 µM 2.14581969045915 0.0121147508645066 no 130 0.0159436835251084 174 704433 SGTC_3123 9126162 49.47 µM 2.14515374730508 0.0121367102374769 no 131 0.0159702781524454 165 25239884 SGTC_767 0929-0023 86 µM 2.13753857684526 0.0123902826098333 no 132 0.0162771057710329 296 1204563 SGTC_1040 k898-0338 155 µM 2.13734876696567 0.0123966611370486 no 133 0.0162848175715034 195 20969351 SGTC_780 0109-0199 192 µM 2.13577736346937 0.0124495771965687 no 134 0.0163487825302256 211 610414 SGTC_354 2783-3500 4.88 µM 2.12416480368894 0.0128467217602372 no 135 0.016828182597179 226 6740761 SGTC_35 0133-0054 64.071 µM 2.11808562633636 0.0130589630958355 no 136 0.0170839083080206 182 99677 SGTC_2033 5192550 145 µM 2.1140719143911 0.0132007485296286 no 137 0.0172545627806386 170 182073 SGTC_1709 st033179 39.1045 µM 2.10928086991297 0.0133717331361801 no 138 0.0174601725200541 191 573381 SGTC_2122 5258151 111.688 µM 2.10792732880427 0.0134203839733828 no 139 0.0175186379469726 197 2173356 SGTC_440 fluspirilene 35.1 µM 2.10655728521177 0.0134697835357447 no 140 0.0175779863078819 209 3396 An atypical antipsychotic. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.10490343730377 0.0135296252743346 no 141 0.017649857218253 182 688669 SGTC_3016 9080866 49.47 µM 2.10192906789325 0.0136378254874293 no 142 0.0177797449007084 199 17066299 SGTC_1184 1269-1718 139 µM 2.0984832510543 0.0137641086283306 no 143 0.0179312389676399 169 5403821 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.09432680969984 0.013917775933951 no 144 0.0181154388395404 228 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_593 1203-0218 61.7 µM 2.08829821185224 0.0141432861141152 no 145 0.0183854713335427 194 3666956 SGTC_2918 7977171 22.06 µM 2.08505002129845 0.0142660903812358 no 146 0.0185323801171588 187 2236483 SGTC_2398 5228213 48.84 µM 2.07919955493464 0.0144895965777264 no 147 0.0187995062792788 272 80771 YMR134W ERG29 SGTC_327 1273-0057 3.96 µM 2.07795014049028 0.0145377167921167 no 148 0.0188569758302966 198 3108138 SGTC_1364 1653-0028 37.6 µM 2.07767810531332 0.0145482122274803 no 149 0.018869508478522 205 5718652 SGTC_739 1486-1183 203 µM 2.06676647553391 0.0149746063865846 no 150 0.0193780819286955 181 4346692 SGTC_1986 st071812 45 µM 2.06315026782607 0.0151182671544427 no 151 0.0195491767422531 139 11838594 SGTC_293 4049-0273 38.5 µM 2.05679893444556 0.0153734533918818 no 152 0.0198527853176525 163 1380311 SGTC_1034 k072-0165 12.7 µM 2.05443416310199 0.0154694064730043 no 153 0.0199668446911933 232 5835461 SGTC_2842 9000675 19.48 µM 2.05387374951349 0.0154922210493378 no 154 0.019993956308877 209 2989072 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.03950823981206 0.0160869822892902 no 155 0.020699664853616 165 61125 An anti-inflammatory. SGTC_2691 st077356 60.2 µM 2.03765432862089 0.0161651454202399 no 156 0.0207922573343086 225 2839272 SGTC_1920 st075728 45.7 µM 2.02957363076587 0.0165096486673319 no 157 0.0211999487705804 216 3400306 SGTC_1600 coumarin 106 71.1 µM 2.02670098682441 0.0166336226852725 no 158 0.0213465007515234 224 100336 A hepatotoxic, DNA x-linker. SGTC_804 1595-0054 20.9 µM 2.01884505086475 0.0169767349429219 no 159 0.0217516634747434 212 761523 Stimulates phospholipase C. SGTC_3275 9138069 49.47 µM 2.01822646842618 0.0170040070151664 no 160 0.0217838403707661 172 17617007 SGTC_500 h-89 112 µM 2.00662647664983 0.0175224062873944 no 161 0.0223947249768576 232 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2273 7815444 169.05 µM 2.00515118453949 0.0175892937877329 no 162 0.0224734434637145 218 2824616 SGTC_2335 9018011 154.17 µM 1.99617909869647 0.018000784819779 no 163 0.0229572158389423 242 6458208 SGTC_385 1494-0393 12.4 µM 1.98958751487115 0.0183083030444643 no 164 0.0233181963047479 227 3090647 SGTC_3198 9112019 49.47 µM 1.98300573494967 0.0186198184290219 no 165 0.0236833944736009 205 45595555 SGTC_2119 5528445 120.635 µM 1.97105988685351 0.0191967471699759 no 166 0.0243585131221371 216 791935 SGTC_80 0159-0065 512.242 µM 1.97094559851622 0.0192023393301326 no 167 0.0243650493491665 121 1548079 SGTC_1253 0550-0034 176 µM 1.96327029290384 0.0195810764604267 no 168 0.0248073876899286 225 5969915 SGTC_979 1426-2828 121 µM 1.95776135221096 0.019856808934041 no 169 0.0251290111714326 269 747872 SGTC_2832 7992762 51.95 µM 1.95646418457537 0.0199222116876408 no 170 0.0252052487803137 225 2985177 SGTC_99 0109-0120 622.8 µM 1.94946726238019 0.0202781544269215 no 171 0.0256198243584098 189 759414 SGTC_3017 9080681 49.47 µM 1.94460836973151 0.0205284923808782 no 172 0.0259110655976451 216 16451914 SGTC_2937 9044753 11.33 µM 1.94146472914491 0.0206918489116862 no 173 0.0261009667950341 283 6465530 YGL099W LSG1 SGTC_745 0469-0705 296 µM 1.94144038987318 0.0206931179629657 no 174 0.0261024416115895 267 3486736 SGTC_1970 st070122 35.8 µM 1.94003307411487 0.0207666076766263 no 175 0.0261878352507501 253 102928 SGTC_833 3852-0053 558 µM 1.93844807349933 0.0208496405433547 no 176 0.0262842900820068 249 3123681 SGTC_127 0180-0333 59.125 µM 1.93676224471198 0.0209382637352159 no 177 0.0263872065326696 324 771601 SGTC_2622 2-methoxyxanthone 59.94 µM 1.92823682122483 0.0213913390794214 no 178 0.0269128380882288 221 71034 A hepatoprotective. SGTC_42 0133-0086 60.653 µM 1.9264953548665 0.0214849000417535 no 179 0.027021275652532 221 162923 Model of phenazepam hydroxylation. SGTC_1356 1502-0781 85.8 µM 1.92203130021674 0.0217263141341427 no 180 0.0273009097015194 237 567702 SGTC_842 0271-0008 11.1 µM 1.91991848385906 0.0218413708872729 no 181 0.0274340983858966 247 1221709 SGTC_3012 9080433 71.4286 µM 1.9145738502961 0.0221347207160133 no 182 0.02777343632561 238 17688859 SGTC_1556 plumbagin 1.48 µM 1.91091350781582 0.022337537952821 no 183 0.0280078484439907 194 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_620 0109-0052 432 µM 1.9086402035123 0.0224642877313133 no 184 0.0281542609336817 240 493037 SGTC_1648 st011736 69.8 µM 1.90154474325683 0.0228638077126829 no 185 0.0286153488692049 215 2855514 SGTC_3292 9120825 59.784 µM 1.89687701142771 0.0231298821439842 no 186 0.028922086082465 236 24824900 SGTC_2676 harmalol 100 µM 1.89673437197541 0.0231380538928633 no 187 0.0289315024150138 242 5459187 A monoamine oxidase inhibitor SGTC_1848 st056003 16.4 µM 1.88871877842022 0.0236011857792132 no 188 0.0294647605185203 247 146492 SGTC_48 0382-0018 55 µM 1.88830285469211 0.0236254286541333 no 189 0.0294926521537335 211 762596 SGTC_532 1548-0774 215 µM 1.88761989693947 0.0236652815227378 no 190 0.0295384984969629 265 5932993 SGTC_1113 artemisinin 1.17947 µM 1.88586181141263 0.0237681318447802 no 191 0.0296567894150898 238 2240 An anti-malaria and mitochondrial poison. SGTC_333 3486-0131 40.1 µM 1.87767674659816 0.0242519295521172 no 192 0.0302126998309954 246 6744690 SGTC_657 3534-0529 86.7 µM 1.87234333262093 0.02457160287127 no 193 0.0305795597038312 254 1049549 SGTC_109 0132-0036 33.701 µM 1.86754829710171 0.0248620184708416 no 194 0.0309125294316007 163 67274 A color developer. SGTC_2375 9072683 200 µM 1.86727010420419 0.0248789554503419 no 195 0.0309319390291453 287 16798029 SGTC_2981 9013952 38.96 µM 1.86660625905881 0.0249194108619291 no 196 0.0309782964476344 269 2996344 SGTC_1319 1306-0155 43.7 µM 1.86328226537997 0.025122808995174 no 197 0.0312112819689389 307 3122360 SGTC_1399 3562-5772 25 µM 1.85832712619595 0.0254286003416417 no 198 0.0315612869773812 210 23847490 SGTC_2278 7948257 134.34 µM 1.85633365597963 0.0255524976174166 no 199 0.0317030073639798 249 1247028 SGTC_1388 3346-4487 254 µM 1.85183053397293 0.0258342351119096 no 200 0.0320250807844394 283 3345614 SGTC_639 0833-0042 114 µM 1.85118571968816 0.0258747898393115 no 201 0.0320714197261735 302 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.85112525018065 0.0258785957181362 no 202 0.0320757681453978 278 688664 SGTC_2265 7929201 200 µM 1.85072975667928 0.0259034991599695 no 203 0.0321042204603604 271 1265108 SGTC_658 3253-0951 102 µM 1.84713365175276 0.0261308601223283 no 204 0.0323638861826724 369 1184878 SGTC_1104 tacrolimus 29.8 µM 1.84269613500177 0.0264137165694845 no 205 0.0326866943268064 285 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_68 0986-0284 82.829 µM 1.84061093218382 0.0265475128012166 no 206 0.0328392972745554 321 423278 YIL048W NEO1 SGTC_2046 4110841 106 µM 1.83927622408588 0.0266334506851302 no 207 0.0329372841310421 251 44119630 YMR134W ERG29 SGTC_2451 5856223 45.7 µM 1.83879644978971 0.026664398649265 no 208 0.0329725653203939 263 2179896 SGTC_1352 1496-0991 99 µM 1.82867157709608 0.0273245437300469 no 209 0.03372441142929 282 3000039 SGTC_188 3229-0966 278.469 µM 1.82659017711229 0.0274619273424973 no 210 0.0338807057018978 330 5722370 SGTC_274 sirtinol 40.1 µM 1.82549493258628 0.0275344503459894 no 211 0.0339631875961922 265 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1088 bifonazole 369 nM 1.81405884604129 0.0283012867178831 no 212 0.0348343332780481 249 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_46 0329-0187a 2.197 µM 1.8097097250261 0.0285975406896577 no 213 0.0351704068069762 392 46494817 SGTC_880 0833-0487 87.2 µM 1.80771305433128 0.0287344115774752 no 214 0.0353255858890809 274 76075 SGTC_3185 9108267 49.47 µM 1.80284004624117 0.0290707423100307 no 215 0.0357066694585268 304 4910486 SGTC_1004 4084-0029 199 µM 1.80070582211499 0.0292190712136149 no 216 0.035874629733447 285 716894 YLR208W SEC13 SGTC_3045 9092950 49.47 µM 1.78877524981346 0.0300598712802313 no 217 0.0368255092177691 297 44120432 SGTC_3242 9133940 49.47 µM 1.78514827771064 0.0303194214817945 no 218 0.0371186344537063 250 17248444 SGTC_1037 k284-1091 78.7 µM 1.78254981865042 0.0305065097626819 no 219 0.0373298073573612 245 3334711 SGTC_3265 9137266 49.47 µM 1.77577419478784 0.0309988545755909 no 220 0.0378850713207722 226 17224265 SGTC_633 0437-0093 97.7 µM 1.76602604211216 0.0317187145576332 no 221 0.0386957399590895 268 2831118 SGTC_57 miconazole 162.5 nM 1.76531361254087 0.0317718616808638 no 222 0.0387555364872621 273 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1645 Cervolide 78 µM 1.76183735418733 0.0320322463163938 no 223 0.039048390751949 251 23173 A fragrance. SGTC_870 0573-2213 57.6 µM 1.76159127485341 0.0320507451586246 no 224 0.0390691895830618 258 3916321 SGTC_446 go6976 132 µM 1.75636234201296 0.0324459162224306 no 225 0.0395132793130094 253 3501 A protein kinase C inhibitor. SGTC_1204 4049-0315 18.3 µM 1.75319245907513 0.0326874277631203 no 226 0.0397844884950692 314 588402 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.75053901088547 0.0328907304793169 no 227 0.0400126743782432 291 688662 SGTC_2102 5377816 72.7585 µM 1.74886608455783 0.033019442139986 no 228 0.0401570851569381 308 1379702 SGTC_2690 usnic acid 100 µM 1.74797893288341 0.0330878660823861 no 229 0.0402338377264225 357 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_683 panaxydol 45 µM 1.74791954486334 0.0330924507109732 no 230 0.0402389799763867 313 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1818 st052136 56.3 µM 1.74676496772654 0.0331816856516455 no 231 0.0403390578421996 336 674169 SGTC_2194 5927483 104.545 µM 1.74570689726515 0.033263635753505 no 232 0.0404309479888354 333 760979 SGTC_1054 3429-0080 167 µM 1.74541752776695 0.0332860771234128 no 233 0.0404561084098957 347 1162877 SGTC_1458 k015-0034 6.33 µM 1.74393589346479 0.0334011772358971 no 234 0.0405851344515394 298 3598957 SGTC_1238 0333-0287 48.8 µM 1.72052215085394 0.035263974282181 no 235 0.0426687853838254 312 7226 SGTC_3204 9114183 49.47 µM 1.71472656117527 0.035737998575647 no 236 0.0431976857069859 321 17027248 SGTC_1085 doxorubicin 7.67 µM 1.71396531000686 0.0358006479042242 no 237 0.0432675485457815 364 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_163 TUB2.036 7.546 µM 1.71375104433565 0.0358182977268582 no 238 0.0432872289463225 516 15992207 YJR013W GPI14 SGTC_1504 k297-0033 30 µM 1.71265113084809 0.0359090137713486 no 239 0.0433883703312867 247 4388117 SGTC_1404 3909-7820 48.3 µM 1.71130478122177 0.0360203108971939 no 240 0.0435124321004786 290 23741373 SGTC_2546 rhodinyl acetate 100 µM 1.71095457060612 0.0360493076108889 no 241 0.0435447497603241 315 6708682 SGTC_465 cgp-37157 41 µM 1.69986981758528 0.0369770254227132 no 242 0.0445777076494125 203 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1032 k061-1018 98.7 µM 1.69579916816261 0.0373225729329109 no 243 0.0449619600435353 380 4005393 SGTC_151 3013-0144 2.285 µM 1.69535288246056 0.0373606169743938 no 244 0.0450042492458076 337 906558 YHR107C CDC12 SGTC_251 melphalan 456.522 µM 1.69358820712005 0.0375113587543258 no 245 0.0451717802619978 369 460612 A DNA alkylator. SGTC_167 3672-0051 66.205 µM 1.6864930371574 0.0381224617097361 no 246 0.0458504375384833 321 3237971 SGTC_1722 st034304 3.6505 µM 1.68570799061015 0.0381905734296687 no 247 0.045926028525336 351 4036148 YLR033W RSC58 SGTC_2757 clomiphene 4.22 µM 1.68362343745121 0.0383719138609913 no 248 0.0461272331281117 381 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2751 anetholtrithion 17.25 µM 1.67941311249745 0.0387403211695859 no 249 0.0465357797641734 351 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1146 3579-1023 7 µM 1.67834741896856 0.0388340258871551 no 250 0.0466396480014443 375 X1146 SGTC_2370 9071495 200 µM 1.67612726549666 0.0390298333241462 no 251 0.0468566335797782 341 21791103 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.67243403617718 0.0393573395436105 no 252 0.0472193825857043 335 6710655 SGTC_2221 6807166 181.081 µM 1.67193301533438 0.0394019405513548 no 253 0.0472687657872305 230 674925 SGTC_2290 7904846 200 µM 1.66707491835378 0.0398365454876624 no 254 0.0477497543775666 347 2962154 SGTC_889 0919-1524 82.7 µM 1.66617445087344 0.0399175277309524 no 255 0.0478393365792433 324 3905452 SGTC_1539 benzyladenosine 56 µM 1.66470619158878 0.0400498604227161 no 256 0.0479856935601861 297 92208 A nucleotide analog. SGTC_3194 9111903 49.47 µM 1.66155883238346 0.0403347297914193 no 257 0.0483006317359623 346 17087251 SGTC_164 4100-3994 89.624 µM 1.66141922547311 0.0403474037125324 no 258 0.0483146396052236 410 4615967 SGTC_886 0866-0150 153 µM 1.65528839881429 0.0409071750631861 no 259 0.0489330055334252 371 271463 SGTC_2116 5511452 16.8835 µM 1.6497728289227 0.0414161386918692 no 260 0.0494947040210586 352 870744 SGTC_956 1185-0240 191 µM 1.63281610075114 0.043013078433834 no 261 0.0512538398753024 347 1416193 SGTC_497 capsazepine 133 µM 1.6297291062558 0.0433090878405945 no 262 0.051579381461412 326 2733484 A calcium channel blocker. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.62960717397868 0.0433208135128276 no 263 0.0515922736053574 363 165521 SGTC_2788 5282734 71.43 µM 1.62474033674083 0.0437909319972333 no 264 0.052108949326125 413 743706 SGTC_358 0075-0058 9.45 µM 1.62300848442118 0.0439592121085114 no 265 0.0522937955838776 478 1069125 SGTC_674 0498-0004 451 µM 1.62239982225218 0.0440184781205392 no 266 0.0523588836027549 367 4231473 SGTC_1716 st033144 30.6155 µM 1.61791501499017 0.0444571569964529 no 267 0.0528404569727825 362 674617 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.60998285771668 0.0452416557351937 no 268 0.0537007993358632 351 4213774 SGTC_664 1222-0054 14.9 µM 1.60900322392373 0.0453393105193122 no 269 0.0538078183399883 377 6813991 SGTC_1214 0358-0031 63.7 µM 1.60410605893616 0.0458300294552539 no 270 0.0543453382931018 365 4301366 SGTC_2517 totarol 10 µM 1.60074081913944 0.0461697099001508 no 271 0.054717168110375 344 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2032 5185112 25.99 µM 1.59620234311245 0.0466310133986422 no 272 0.0552218123279988 331 5718189 SGTC_176 1486-1328 72.834 µM 1.59224418132295 0.0470363448602805 no 273 0.0556649247756987 421 22310231 SGTC_942 3253-1115 227 µM 1.59086584937107 0.0471781528909196 no 274 0.055819884807022 372 46497897 SGTC_31 0508-1974 57.237 µM 1.58932422495277 0.0473371668726588 no 275 0.0559936061365816 359 6810525 SGTC_79 0052-0007 94.094 µM 1.58683160089139 0.0475951820046481 no 276 0.0562753948104386 375 2801472 SGTC_223 busulfan 5 mM 1.58679420468341 0.0475990614999319 no 277 0.0562796309110588 282 2478 A DNA alkylator. SGTC_1057 3448-5381 134 µM 1.58668056076278 0.047610852513168 no 278 0.0562925056061439 394 5497911 SGTC_2007 4011539 71.82 µM 1.58484639871819 0.0478014779596621 no 279 0.0565006187259329 401 45595301 SGTC_178 4092-0806 87.505 µM 1.58366324467152 0.0479247677002939 no 280 0.0566351866330552 499 2169044 SGTC_84 0443-0269 128.823 µM 1.58095622835922 0.0482078079435685 no 281 0.0569440231885547 396 6150058 SGTC_1425 4048-4433 7.33 µM 1.57907205215449 0.0484056018964123 no 282 0.0571597656361794 424 23734946 SGTC_726 3448-4391 34.2 µM 1.57147424374681 0.0492097861598842 no 283 0.058036266247762 405 1356692 SGTC_1322 1348-1070 12 µM 1.57006737460819 0.0493598593386501 no 284 0.0581997188683051 319 6758089 SGTC_592 k241-0073 46.5 µM 1.56567095127323 0.0498311895931405 no 285 0.0587128351020711 399 4230158 SGTC_1501 4491-0275 38.4 µM 1.5654049423946 0.0498598225691567 no 286 0.058743995145854 356 5104718 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.56474148867674 0.049931293362161 no 287 0.0588217680819202 401 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1315 1237-0019 3.69 µM 1.56300612258693 0.0501186226987536 no 288 0.0590255773673279 382 825140 SGTC_2483 5729050 27.16 µM 1.55308914789428 0.0511999141401037 no 289 0.0602009191730817 491 2865180 SGTC_325 2810-4341 181 µM 1.5529367932782 0.0512166696717962 no 290 0.0602191178269646 361 774970 SGTC_3281 9140613 49.47 µM 1.55023957997548 0.051514024501616 no 291 0.0605420115866956 344 16013766 SGTC_912 3474-0017 2.18 µM 1.54865054837129 0.0516898492395187 no 292 0.0607328737799633 401 3360550 SGTC_1527 coumarin 137 µM 1.54748087156849 0.0518195773606081 no 293 0.0608736667590332 376 323 A hepatotoxic, DNA x-linker. SGTC_1081 sertraline 6 µM 1.54013268874366 0.0526404885781413 no 294 0.0617640065867536 451 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_914 3820-6779 408 µM 1.53822576390037 0.0528552009193625 no 295 0.0619967118114884 392 2893481 SGTC_1873 rapamycin 2 nM 1.53032626596096 0.0537520627991845 no 296 0.0629679949560433 469 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1728 st035614 33.7865 µM 1.52907686515324 0.053895009772368 no 297 0.0631226949124314 489 15945546 SGTC_891 0929-0073 133 µM 1.52780190063635 0.0540411916709206 no 298 0.0632808651191665 379 5603632 SGTC_723 4182-0001 115 µM 1.527405024903 0.05408675971786 no 299 0.0633301638591836 387 744821 YLR208W SEC13 SGTC_2983 9022671 12.99 µM 1.52498184301961 0.0543656420220169 no 300 0.0636318132473048 380 6405161 SGTC_2592 piperlongumine 83.33 µM 1.52235337306114 0.0546694356935078 no 301 0.0639602806323081 387 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3301 9125354 19.7965 µM 1.52222946020309 0.0546837903731979 no 302 0.0639757979155398 361 41905162 SGTC_2268 7933382 153.85 µM 1.5177588566639 0.0552036833203074 no 303 0.0645376002868872 485 935025 YOR257W CDC31 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.51764803550472 0.0552166202913249 no 304 0.0645515752491084 465 4174840 SGTC_1242 0402-0103 60.1 µM 1.51467848929952 0.0555641699343482 no 305 0.0649269222193336 392 432868 SGTC_1791 st048313 56.1 µM 1.51290488898079 0.0557725707613125 no 306 0.0651519099420556 357 1204976 SGTC_221 trifluoperazine 10.304 µM 1.5046114041853 0.0567552647284296 no 307 0.0662120062858884 607 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_492 tmb-8 126 µM 1.50411889130785 0.0568140488266669 no 308 0.0662753784579151 245 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_790 1575-0012 79.1 µM 1.49921956032109 0.0574014250442381 no 309 0.0669083411179811 435 378741 YLR208W SEC13 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.49621043429473 0.0577645480486105 no 310 0.0672994131578209 465 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.49237951656413 0.0582294503873141 no 311 0.0677998408683104 448 1273210 SGTC_2245 6637752 200 µM 1.49071124394017 0.0584328206940468 no 312 0.0680186613797541 350 681890 SGTC_2220 6782180 200 µM 1.49035105348819 0.0584768027405272 no 313 0.0680659775851492 322 833803 SGTC_2707 st078556 66.6 µM 1.47976460899448 0.0597811363379321 no 314 0.0694680382752414 399 17250899 SGTC_656 4090-1979 187 µM 1.47941920054317 0.0598240742556267 no 315 0.069514155799059 477 22330961 SGTC_2932 9016711 44.54 µM 1.46649109334747 0.0614486153738403 no 316 0.071257272943493 482 7117328 SGTC_382 3229-0966 23.2 µM 1.46484062254253 0.0616584699646411 no 317 0.0714822029465013 460 5722370 SGTC_2067 5224629 34.075 µM 1.46445341664981 0.0617077834906056 no 318 0.0715350510909554 458 2835000 SGTC_132 0417-1715 25.805 µM 1.46245616102072 0.0619626379310781 no 319 0.0718081246016423 462 6769098 SGTC_1618 st003135 44.5 µM 1.45750960774513 0.0625973659311409 no 320 0.072487880604292 417 1270615 SGTC_1447 4239-0816 81.9 µM 1.45370129023349 0.0630894827943018 no 321 0.0730145701638437 426 1341554 SGTC_710 3448-4187 58 µM 1.44840715921291 0.0637785982387721 no 322 0.0737516068787973 558 3946412 SGTC_2088 5278280 127.392 µM 1.44744682039584 0.0639042266673894 no 323 0.0738859102736955 483 791502 SGTC_1485 3909-9022 254 µM 1.44737637139727 0.0639134501495929 no 324 0.0738957699202983 458 714516 SGTC_1948 st076329 66.6 µM 1.44457246522496 0.0642813907222513 no 325 0.0742890057865561 419 24208413 SGTC_2745 rifampicin 24.3 µM 1.44432655860413 0.0643137379992595 no 326 0.0743235692151852 278 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3047 9092122 49.47 µM 1.44012066000836 0.0648689547669339 no 327 0.0749166324565301 446 17173831 SGTC_2252 omeprazole 400 µM 1.43507958362037 0.065539317411552 no 328 0.0756322103425553 337 4594 A proton pump inhibitor. SGTC_1380 2291-0730 164 µM 1.43136721775875 0.0660364134851758 no 329 0.0761624993022141 431 2999191 SGTC_671 0560-0003 407 µM 1.43098806754006 0.066087346715268 no 330 0.076216817496069 439 3238678 SGTC_2271 7849410 118.62 µM 1.42921958108458 0.0663253188721905 no 331 0.0764705657067179 443 972430 SGTC_1010 4112-3296 15.2 µM 1.42696291474209 0.0666299447625093 no 332 0.0767952922148941 496 704384 SGTC_2870 9038528 12.99 µM 1.42680863940666 0.0666508097675844 no 333 0.0768175301330272 418 6463316 SGTC_443 clozapine 122 µM 1.42662191210853 0.0666760705099763 no 334 0.0768444523668925 370 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1300 1094-0077 113 µM 1.4257276073257 0.0667971561023784 no 335 0.0769734921710461 419 5532636 SGTC_2017 5132927 60.65 µM 1.42362648452692 0.0670823098432076 no 336 0.0772773124869413 475 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1175 0741-0056 27.6 µM 1.42236360412161 0.0672541539875611 no 337 0.0774603616035725 531 765927 SGTC_1785 bathophenanthroline 24 µM 1.42112001853781 0.067423705003654 no 338 0.0776409356150047 487 72812 An iron chelator. SGTC_2639 lactacystin 53 µM 1.41887961626368 0.067729995931623 no 339 0.0779670579768573 504 3870 A proteasome inhibitor. SGTC_1925 st057770 10.1 µM 1.41870435715663 0.0677540012918316 no 340 0.0779926131970333 435 5989122 SGTC_1575 cyproterone acetate 48 µM 1.41545238738476 0.0682006191091182 no 341 0.0784679494857627 472 9880 An androgen receptor antagonist and liver toxin. SGTC_1972 st070201 17.4 µM 1.41379370503795 0.0684292919600117 no 342 0.0787112412014173 472 2829099 SGTC_736 0958-0254 92.6 µM 1.41369966698558 0.0684422741351691 no 343 0.0787250515904021 501 6812352 SGTC_3284 9108171 64.8615 µM 1.41228246030335 0.068638153042578 no 344 0.0789334043838577 431 8687505 SGTC_429 1112-0049 25.5 µM 1.41019465291555 0.0689275061430882 no 345 0.0792411071317112 446 2836170 SGTC_3075 9116269 49.47 µM 1.40972690684718 0.0689924606820123 no 346 0.0793101682810965 472 17015205 YNL244C SUI1 SGTC_2958 9077254 16.72 µM 1.4045401277325 0.0697158993552472 no 347 0.0800790355763276 434 16457351 SGTC_1876 myriocin 605 nM 1.40399627801336 0.0697920911099847 no 348 0.0801599789518896 470 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2173 5763948 167 µM 1.40258202807505 0.0699905234176509 no 349 0.0803707570504811 506 2867177 SGTC_337 1315-0038 354 µM 1.40183090980659 0.0700960885846137 no 350 0.0804828729461917 468 1626437 SGTC_1258 0671-0043 57.1 µM 1.39902323446431 0.0704917753864845 no 351 0.0809030078797006 494 4298767 SGTC_3332 9141069 11.198 µM 1.38941149463254 0.0718593697780752 no 352 0.0823538284699545 424 17332883 SGTC_1407 3909-7909 12.3 µM 1.38692962163786 0.0722157840927697 no 353 0.0827316121471982 500 4411780 SGTC_2460 5552655 174.22 µM 1.38258734202412 0.0728426225682865 no 354 0.0833957162423404 489 5401989 SGTC_2900 5328528 85.29 µM 1.37722511394547 0.0736224357365036 no 355 0.0842213297907735 546 795359 SGTC_1630 st005209 31.3 µM 1.37574385543169 0.0738389719356522 no 356 0.0844504745941474 547 3367314 SGTC_146 3448-8650 53.125 µM 1.37431631892087 0.0740481150846304 no 357 0.084671751124979 670 2891488 YIL048W NEO1 SGTC_2276 7947513 42.08 µM 1.37129207494881 0.0744926805714571 no 358 0.0851419625974683 459 2105100 SGTC_3188 9110789 49.47 µM 1.3712324348698 0.0745014681367792 no 359 0.0851512551120801 523 849217 SGTC_1125 tnp00248 1.32998 µM 1.36975688971057 0.0747191318767427 no 360 0.085381401721188 629 24207736 SGTC_1225 1216-0074 20.6 µM 1.36946388253238 0.0747624122619447 no 361 0.0854271586062108 487 4241466 SGTC_312 4092-0653 6.84 µM 1.36872605971442 0.0748714815415185 no 362 0.0855424605952792 596 1148278 SGTC_81 0411-0046 9.971 µM 1.36852248468362 0.0749015965483154 no 363 0.0855742944363223 454 12925265 SGTC_416 estradiol valerate 100 µM 1.36147300643218 0.0759501407806012 no 364 0.0866821291908657 488 13791 A steroid. SGTC_2195 6536160 144.242 µM 1.35557750341076 0.0768355930726581 no 365 0.0876168168291443 432 3834386 SGTC_2022 5136654 200 µM 1.35452828225895 0.0769939961500144 no 366 0.0877839482980547 506 1713771 SGTC_1430 4049-0248 69.1 µM 1.35396038470156 0.077079836278128 no 367 0.0878745083933156 565 22774488 SGTC_1751 st044839 27.194 µM 1.35238859559799 0.0773177980829885 no 368 0.0881255178860072 475 5291326 SGTC_2775 cyproheptadine 69.59 µM 1.35186552151805 0.0773971127819615 no 369 0.0882091695051393 510 2913 A selective serotonin reuptake inhibitor. SGTC_896 0964-0007 44.5 µM 1.35182144663666 0.0774037987603928 no 370 0.0882162207988232 505 6756758 SGTC_2659 sanguinarine 24.21 µM 1.3514730346701 0.0774566668652212 no 371 0.0882719760685979 502 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2972 9093619 59.92 µM 1.34757725713063 0.0780496819679759 no 372 0.0888971947568967 487 25236256 SGTC_283 0987-0079 11.7 µM 1.34552187499619 0.078363936989982 no 373 0.0892283809738438 561 411556 SGTC_2986 9022445 71.43 µM 1.34210795554341 0.0788880226794907 no 374 0.0897804973799867 515 6459286 SGTC_1840 st055363 71 µM 1.34100531050664 0.0790578605953512 no 375 0.0899593642093283 450 676033 SGTC_3 0833-0587 95.581 µM 1.34040559756358 0.0791503492079321 no 376 0.0900567584456936 508 5382644 SGTC_375 3970-0961 9.27 µM 1.33985395676781 0.0792354963849921 no 377 0.0901464148531349 515 2898222 SGTC_695 3505-6186 243 µM 1.33945104373983 0.0792977308589463 no 378 0.0902119409041268 537 1819379 SGTC_391 gliotoxin 8.33 µM 1.336414380322 0.0797679688180798 no 379 0.090706934305099 558 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2145 5634607 200 µM 1.33307355418475 0.0802877408288202 no 380 0.0912538335026344 451 308662 SGTC_1406 3909-7906 11.9 µM 1.33050882619829 0.0806884996305327 no 381 0.0916753401278566 533 X1406 SGTC_141 0443-0274 32.331 µM 1.32601872929995 0.0813937471100625 no 382 0.0924167468359946 653 1627241 SGTC_399 oxolinic acid 75 µM 1.32237113172184 0.0819700801199925 no 383 0.0930222984550195 500 4628 A DNA gyrase inhibitor. SGTC_3315 9136395 68.55 µM 1.32150601190882 0.0821072221018864 no 384 0.0931663496426091 555 16876844 SGTC_205 1486-1330 71.903 µM 1.31956965006554 0.0824148076342852 no 385 0.0934893707452558 466 4118834 SGTC_717 1532-0246 73.2 µM 1.31951796536884 0.0824230294715762 no 386 0.0934980040319045 557 9561992 SGTC_732 3970-1727 52.7 µM 1.31948282198424 0.0824286203222169 no 387 0.0935038746341042 499 1275699 SGTC_808 0711-0032 135 µM 1.31859029266323 0.0825707057337441 no 388 0.0936530603786636 510 4252555 SGTC_1910 st062352 60.4 µM 1.31835215817245 0.0826086464799316 no 389 0.09369289410241 528 2245730 SGTC_305 1682-2595 20.8 µM 1.31316387012782 0.0834385304459958 no 390 0.094563867798079 557 226033 SGTC_2100 5377183 190 µM 1.31166377056354 0.083679640241546 no 391 0.0948168029849883 580 2844202 SGTC_2787 5284540 71.43 µM 1.3110970331095 0.0837708676018815 no 392 0.0949124915065837 525 736958 SGTC_2001 4023502 57.655 µM 1.31035876713145 0.0838898178162549 no 393 0.0950372477564564 556 108941 YCR052W RSC6 SGTC_991 3996-0057 64.7 µM 1.31012886087823 0.0839268864503092 no 394 0.0950761232347366 527 715343 SGTC_3091 9116372 49.47 µM 1.30602020517534 0.0845914158875564 no 395 0.0957728432632854 492 17169793 SGTC_1607 st000305 50.6 µM 1.30449552599287 0.0848390172953461 no 396 0.0960323419863593 553 5457690 SGTC_2520 obtusaquinone 4.71 µM 1.30238659846667 0.0851823932157353 no 397 0.0963921307569194 537 5967872 SGTC_3183 9108214 49.47 µM 1.301288710214 0.0853615632293311 no 398 0.0965798250813945 386 4974831 SGTC_935 2996-0153 430 µM 1.29877469631796 0.0857729011548461 no 399 0.0970106304255409 541 23738523 SGTC_3234 9132280 49.47 µM 1.29836352565096 0.0858403170180479 no 400 0.0970812232836963 572 17612295 SGTC_2739 tacrine 100.86 µM 1.29619315156963 0.0861968305498359 no 401 0.0974544741943871 510 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_73 0327-0325 16.231 µM 1.2949779212377 0.0863969317708493 no 402 0.0976639230280676 635 53298 SGTC_2850 9015429 58.44 µM 1.29391079957338 0.0865729314943627 no 403 0.0978481168654651 509 6457570 SGTC_1847 st056231 15 µM 1.29214557903685 0.0868646563668074 no 404 0.0981533669885755 608 5393180 SGTC_1581 himbacine 57.9 µM 1.28777470774263 0.0875901576406128 no 405 0.0989121994815188 572 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1200 1643-0193 18.4 µM 1.28564895978811 0.0879446309836257 no 406 0.0992828008167331 595 5403974 SGTC_1133 3473-0247 50 µM 1.28344808057258 0.0883127586579065 no 407 0.0996675691227509 596 711311 SGTC_398 bronopol 33.3 µM 1.2814488045959 0.0886481597054758 no 408 0.100018035562609 556 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1003 4049-0218 100 µM 1.27651331008332 0.0894802050863233 no 409 0.10088706238588 590 295161 SGTC_2876 9059903 25.97 µM 1.27547038440443 0.0896567666326154 no 410 0.101071400029106 592 6916095 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.27409259746317 0.0898904153047669 no 411 0.101315300787965 657 6708739 YPR165W RHO1 SGTC_3089 9117425 49.47 µM 1.27385114533577 0.0899314079407838 no 412 0.101358087625753 530 9401657 SGTC_1449 4112-4002 201 µM 1.27250044003996 0.0901609807601724 no 413 0.101597683917867 537 2059539 SGTC_1318 1280-3875 124 µM 1.27199983076281 0.0902461773733715 no 414 0.101686589699943 603 373245 SGTC_702 1488-0190 94 µM 1.27039598034772 0.0905195326751966 no 415 0.101971807187055 567 949357 SGTC_2144 5628481 200 µM 1.26922683017773 0.0907191860472031 no 416 0.102180087204624 508 2818399 SGTC_2629 bisabolol 100 µM 1.26905608869128 0.0907483705475745 no 417 0.102210530082862 597 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_858 0438-0351 2.77 µM 1.26679099601832 0.0911361978513812 no 418 0.102615016232152 606 2799119 SGTC_907 3448-6986 75.5 µM 1.26406972245307 0.0916037558502575 no 419 0.103102501430455 625 590582 SGTC_2532 xanthone 78.9 µM 1.25965020833786 0.092366882252153 no 420 0.10389778735462 524 7020 An insecticide. SGTC_602 3130-1533 38.1 µM 1.25809021143418 0.0926373703915759 no 421 0.10417956648511 622 720941 SGTC_2651 TUB2.036 5 µM 1.25764539000978 0.0927146053017443 no 422 0.104260015101725 761 15992207 YFL037W TUB2 SGTC_1583 clindamycin 39.6 µM 1.25046514539024 0.093967916408239 no 423 0.10556483998378 540 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_58 0957-0393 9 µM 1.25030222403551 0.0939964986715629 no 424 0.105594583149622 833 6997992 SGTC_2720 fluspirilene 36.88 µM 1.24729648363434 0.0945249651266666 no 425 0.106144403159941 518 3396 An atypical antipsychotic. SGTC_3244 9134489 49.47 µM 1.24668874062407 0.0946320836416412 no 426 0.106255824436324 581 16584271 SGTC_3098 9119039 49.47 µM 1.24097622087704 0.0956433272975709 no 427 0.107307266697406 592 17161528 SGTC_2959 9079155 11 µM 1.23670627704884 0.0964043797100957 no 428 0.108098073745683 517 16189457 SGTC_2198 6589944 200 µM 1.23322198965139 0.0970286905988268 no 429 0.108746476703995 487 5290268 SGTC_1494 4358-1428 177 µM 1.23296657607275 0.0970745718073946 no 430 0.10879411727934 613 1564571 SGTC_673 1082-0474 110 µM 1.22910613367282 0.0977699825096313 no 431 0.109516007877004 696 3098046 SGTC_1255 0566-0045 221 µM 1.22894638542991 0.0977988376549498 no 432 0.109545954237211 609 2788469 SGTC_1993 st073995 70.8 µM 1.22806559549048 0.0979580458553828 no 433 0.109711172459963 611 3098394 SGTC_836 0330-0104 1.35 µM 1.22784435218165 0.0979980667750029 no 434 0.109752701286431 604 46494820 SGTC_663 1486-0733 13.9 µM 1.22713073353565 0.0981272356023727 no 435 0.109886729101563 674 722445 YPR165W RHO1 SGTC_317 4495-0002 170 µM 1.22485944837131 0.0985391806940468 no 436 0.110314090787932 538 15991618 SGTC_2395 5646831 180.19 µM 1.22216175263686 0.0990301074752752 no 437 0.110823232188477 595 6808628 SGTC_999 SEC7.066 22.7 µM 1.22058447415425 0.0993179682072319 no 438 0.111121693865138 638 740511 YDR170C SEC7 SGTC_1998 st075797 76.8 µM 1.21867959479851 0.0996664325922632 no 439 0.111482912837461 669 24208315 SGTC_1719 st032227 49.2 µM 1.21510013854266 0.100323646452249 no 440 0.112163950380358 592 3125804 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.21375311322413 0.100571787283855 no 441 0.112421007794258 571 2374 Ca(2+)-ATPase inhibitor. SGTC_1742 st038235 28.8875 µM 1.21128790459106 0.101027072017899 no 442 0.112892541372187 626 564103 YBR002C RER2 SGTC_1856 st057054 55.7 µM 1.2097032315264 0.101320528042117 no 443 0.113196394712561 654 1266018 SGTC_357 1325-0123 420 µM 1.20596613731644 0.102015036058089 no 444 0.113915273717103 580 1098503 SGTC_1383 3049-0032 20.7 µM 1.20528960257483 0.102141133877573 no 445 0.11404576102914 618 712864 SGTC_2343 7990716 14.84 µM 1.20305792367049 0.102557895488938 no 446 0.114476953167481 632 6456862 SGTC_756 0508-1999 28.3 µM 1.19949967510582 0.103224945946488 no 447 0.115166855506675 598 6753853 SGTC_3192 9110362 49.47 µM 1.19743771783815 0.103612931558221 no 448 0.115567994858015 646 16649480 SGTC_1940 st075990 51.1 µM 1.19657279199638 0.103775993895366 no 449 0.115736555311753 682 1084979 SGTC_3305 9127027 53.8275 µM 1.19575038868785 0.103931212144053 no 450 0.115896990671998 623 41905295 SGTC_2920 7982904 15.77 µM 1.19516759473575 0.104041309036612 no 451 0.116010778330793 555 6456808 SGTC_2977 9011197 71.43 µM 1.19487078949631 0.104097411659315 no 452 0.116068758567025 544 2704722 SGTC_1302 1159-0335 255 µM 1.19431603185075 0.104202331681176 no 453 0.116177184371308 601 649284 SGTC_2528 xanthyletin 44.79 µM 1.19103897524196 0.104823677866448 no 454 0.116819142296998 607 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2124 5246320 200 µM 1.18804655536497 0.105393394914561 no 455 0.117407534236053 621 579342 SGTC_3323 9138564 53.9225 µM 1.18475109391156 0.106023394854444 no 456 0.11805793715708 697 43912313 YNL103W MET4 SGTC_1841 st054148 70 µM 1.18230059696109 0.10649362209017 no 457 0.118543224402175 583 675442 SGTC_558 k064-0027 21.3 µM 1.18186692213603 0.106576996765327 no 458 0.11862925434989 637 5088526 SGTC_2081 5214970 32.255 µM 1.18112000246224 0.106720703704508 no 459 0.118777527431987 616 2063512 SGTC_1426 4048-4480 71.7 µM 1.17574417671989 0.107759136256918 no 460 0.119848559816509 640 14224343 SGTC_196 k015-0023 18.111 µM 1.17476981535912 0.107948127356178 no 461 0.12004340965839 670 5211998 SGTC_943 3253-1379 105 µM 1.17259230099645 0.108371349409589 no 462 0.120479669151011 636 668464 SGTC_699 0375-0592 111 µM 1.1705597167713 0.10876747904269 no 463 0.120887898700867 672 762578 SGTC_3093 9117344 49.47 µM 1.1683364363027 0.109201964525796 no 464 0.121335541778589 605 24824913 SGTC_1578 josamycin 24.2 µM 1.16802196506167 0.109263520725302 no 465 0.121398952488573 586 5282165 A P450 substrate. SGTC_980 1473-0395 201 µM 1.16540893098793 0.109775973651603 no 466 0.121926751951631 579 768876 SGTC_884 0851-0618 334 µM 1.16525574765298 0.109806068511597 no 467 0.121957742963054 674 9642473 SGTC_3333 9141820 12.094 µM 1.16358975629174 0.110133756681484 no 468 0.122295152343771 593 1939433 SGTC_2406 ethylparaben 405.7 µM 1.16353878625339 0.110143793158074 no 469 0.122305485507856 549 8434 A possible steroid mimic. SGTC_1808 st050063 61.5 µM 1.16347930341143 0.110155506714786 no 470 0.122317545248899 635 4011993 SGTC_1914 st062367 72.6 µM 1.16226620688833 0.110394588632241 no 471 0.122563674410599 615 978205 SGTC_2431 5490079 200 µM 1.16163441440202 0.110519252067234 no 472 0.122691998396547 657 5722345 SGTC_2440 5628896 157.78 µM 1.1611807423485 0.11060883153107 no 473 0.122784202282455 629 5522048 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.16028545684937 0.110785762091966 no 474 0.122966301825069 684 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_502 l-744,832 89.3 µM 1.16023351089093 0.110796034119152 no 475 0.122976873353066 664 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_470 aa-861 153 µM 1.15183834553204 0.112465109134526 no 476 0.124693753728331 688 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2371 9071574 200 µM 1.15174537832497 0.112483692316078 no 477 0.124712859606383 589 45596039 SGTC_3318 9139014 38.6185 µM 1.14636352166164 0.113563211197402 no 478 0.125822384842038 635 16643984 SGTC_1275 0867-0008 21.1 µM 1.14611337125976 0.113613566612748 no 479 0.125874122842183 669 3422836 SGTC_1487 3970-0795 2.82 µM 1.14439685024178 0.113959532669259 no 480 0.126229546943556 700 3765103 SGTC_3339 9145883 14.936 µM 1.14367942173084 0.114104353105981 no 481 0.126378305289711 633 2030670 SGTC_1366 1683-0113 21.9 µM 1.14286218264296 0.114269481012182 no 482 0.12654790806807 630 708623 SGTC_1101 ebselen 5.29 µM 1.13387544682151 0.116096534600607 no 483 0.128423398850654 728 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3214 9129694 49.47 µM 1.13356368100304 0.116160288358504 no 484 0.1284888074519 646 17158655 SGTC_2967 9089538 49.85 µM 1.13211640131612 0.116456571528144 no 485 0.128792750155147 700 728216 SGTC_2372 9071633 200 µM 1.13039333811217 0.116810010860223 no 486 0.129155259999091 745 21321366 SGTC_693 4161-2696 114 µM 1.12813911026353 0.117273551306127 no 487 0.129630587098974 627 805759 SGTC_596 1155-0152 116 µM 1.12657638866578 0.117595659966075 no 488 0.129960813320983 731 280313 SGTC_2742 clothiapine 36.27 µM 1.1229055282504 0.118354760957251 no 489 0.130738809694571 623 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_844 0330-0132 15.3 µM 1.11980539213689 0.118998534078286 no 490 0.131398350493011 719 2828079 SGTC_2806 7952793 58.44 µM 1.1194628066251 0.119069826686278 no 491 0.131471374810778 691 2972490 SGTC_2242 6630449 61.2675 µM 1.1107090724677 0.120901730812776 no 492 0.13334679791184 603 691249 YDR170C SEC7 SGTC_3328 9140624 29.0385 µM 1.10922723908279 0.12121378822026 no 493 0.133666082301192 722 4904392 SGTC_371 0195-0006 7.36 µM 1.1086493305423 0.121335642654611 no 494 0.133790744171176 619 3928593 SGTC_1591 genipin 88.4 µM 1.10833635410065 0.121401670991259 no 495 0.133858290329985 666 442424 A DNA cross-linking agent. SGTC_452 diindolylmethane 8 µM 1.10694605122281 0.121695287191896 no 496 0.134158626936767 642 3071 Inhibits expression of several cancer promoting factors. SGTC_3291 9121177 71.43 µM 1.10647377879337 0.121795139224681 no 497 0.13426075362162 604 17015612 SGTC_3289 9119912 71.43 µM 1.10616938621718 0.121859527105581 no 498 0.134326605370282 689 17014829 SGTC_2682 pyrogallin 40.03 µM 1.10349843731485 0.12242553604148 no 499 0.134905384900642 747 822798 An ATP competetive kinase inhibitor. SGTC_1115 galangin 695.678 nM 1.10344811912808 0.122436216798806 no 500 0.134916304960008 757 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2196 6573537 42.6665 µM 1.10164553402516 0.122819272740966 no 501 0.135307902185455 696 2903087 SGTC_82 0054-0107 293.755 µM 1.10001807411001 0.123165835183785 no 502 0.13566212350131 694 3104697 SGTC_1174 0739-0097 51.1 µM 1.09849177379974 0.123491478259218 no 503 0.13599490389077 711 728447 SGTC_3252 9135871 49.47 µM 1.09751823952545 0.123699500934656 no 504 0.136207455964046 702 17682838 SGTC_1224 0823-0416 294 µM 1.09743736874207 0.123716792257358 no 505 0.136225122731247 729 3598164 SGTC_2812 7970281 58.44 µM 1.09735174835917 0.123735100956162 no 506 0.136243828789294 709 2233435 SGTC_1760 st045453 10.4495 µM 1.09545418542 0.124141354714623 no 507 0.136658853242738 741 3323419 YIL048W NEO1 SGTC_419 nsc-638432 893 µM 1.09229938255251 0.124818837575431 no 508 0.137350765830581 708 368090 SGTC_681 1642-0006 26.6 µM 1.09156504526806 0.124976903900435 no 509 0.137512163599091 698 4446530 SGTC_3132 9126706 49.47 µM 1.0901714271663 0.125277264989527 no 510 0.137818818594742 683 850858 SGTC_3227 9130768 49.47 µM 1.08972365212297 0.125373879097443 no 511 0.137917447030947 742 17720899 SGTC_3039 9090270 49.47 µM 1.08691116322886 0.125981904587227 no 512 0.138538036160232 667 17173750 SGTC_1163 k060-0048 49.9 µM 1.0864950487275 0.126072037733054 no 513 0.138630015144021 754 6809982 SGTC_2277 7947813 106.88 µM 1.08595557158381 0.126188958952174 no 514 0.138749324431378 678 1246798 SGTC_3233 9132340 49.47 µM 1.08542607273756 0.126303791044994 no 515 0.138866494935519 707 17682950 SGTC_3162 9099653 49.47 µM 1.08315415218618 0.126797327534445 no 516 0.139370003031399 659 25237511 SGTC_2115 tiliquinol 12.7705 µM 1.07786788125015 0.127950873004024 no 517 0.140546360417989 708 71208 A bioactive hydroxyquinoline. SGTC_1150 3909-7983 10.9 µM 1.07775350627412 0.127975911705854 no 518 0.140571886629718 735 23965914 SGTC_3300 9124615 50.48 µM 1.07313513448935 0.128989799768717 no 519 0.141605244510636 718 24824903 SGTC_1185 1319-0113 81.3 µM 1.07253013389027 0.129123029273785 no 520 0.141740993292698 677 4672763 SGTC_8 0354-0001 70 µM 1.07232412487786 0.129168417075992 no 521 0.141787237278117 830 4993152 SGTC_1178 0988-0033 191 µM 1.06942132444836 0.129809136660077 no 522 0.142439931359352 746 5392207 SGTC_2933 9026794 32.47 µM 1.06309416721126 0.131213312860744 no 523 0.14386962466044 756 17586027 SGTC_1412 3909-8563 178 µM 1.05739577333607 0.132486896914527 no 524 0.145165499857958 824 23767530 SGTC_1851 st056236 18.9 µM 1.05579500571208 0.132846193910906 no 525 0.14553094023136 769 5393171 SGTC_428 3448-4153 16.5 µM 1.05502883477581 0.133018400436349 no 526 0.14570606866445 655 3834874 SGTC_949 1165-0505 146 µM 1.05292001390384 0.133493177670938 no 527 0.14618882627471 801 6244267 SGTC_566 0958-0068 16.5 µM 1.04898223851643 0.13438284040406 no 528 0.147093146581963 669 6815365 SGTC_1312 1218-2183 165 µM 1.04687902149741 0.134859685102038 no 529 0.147577689276167 788 6744073 SGTC_3128 9127691 49.47 µM 1.04540033677961 0.135195628989166 no 530 0.14791899056382 646 41316314 SGTC_1762 st045503 25.4615 µM 1.04516520462398 0.135249101729377 no 531 0.147973311034714 759 4645554 SGTC_938 3126-1755 342 µM 1.04420746283136 0.135467057029449 no 532 0.148194707469358 808 1777771 SGTC_108 0509-0257 621.132 µM 1.04318541046463 0.135699912965905 no 533 0.148431214598931 791 536624 SGTC_3257 9139206 32.98 µM 1.03893128898544 0.136672081324535 no 534 0.149418346666987 733 4910041 SGTC_869 0564-0080 44.1 µM 1.03774956279739 0.136942977050708 no 535 0.149693331947561 754 6843321 SGTC_2984 9022109 38.96 µM 1.03399795162075 0.137805416755648 no 536 0.150568560419434 744 6459207 SGTC_3180 9109287 49.47 µM 1.03338040122005 0.137947736870007 no 537 0.150712957281719 718 18891271 SGTC_2713 st079149 53.4 µM 1.03118753558152 0.138453912635636 no 538 0.151226442304717 788 3103253 SGTC_184 1494-0393 24.714 µM 1.0287503605502 0.139017965358456 no 539 0.151798499134013 774 3090647 SGTC_1939 st074455 53.6 µM 1.02749254089722 0.1393096826685 no 540 0.152094297988806 788 1644229 SGTC_230 MPP+ 141.667 µM 1.02733300790663 0.139346711779774 no 541 0.152131842368837 735 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2607 solasodine 47.35 µM 1.02723298453063 0.139369931563486 no 542 0.152155384937344 779 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3140 9094243 49.47 µM 1.02649042562299 0.139542394146616 no 543 0.152330237162898 814 19291112 SGTC_2057 5236571 38.335 µM 1.02377725552788 0.1401737735255 no 544 0.152970247798197 798 54684039 YBR257W POP4 SGTC_13 0199-0087 65 µM 1.02326189471319 0.14029392164901 no 545 0.153092017622104 787 4589825 SGTC_1984 st072354 53.1 µM 1.02269570855544 0.140425999492692 no 546 0.153225870541122 772 5762938 SGTC_2332 7982454 138.89 µM 1.02128658256942 0.140755081705843 no 547 0.153559340720026 791 2981748 SGTC_1903 st060211 78.3 µM 1.01822683398626 0.141471444960751 no 548 0.154285084940626 822 688960 SGTC_2459 5811157 9.22 µM 1.0180822429708 0.141505358339514 no 549 0.154319436633782 786 2870684 YBR192W RIM2 SGTC_1749 st037932 54.2 µM 1.01621555872793 0.141943678029874 no 550 0.154763374464803 736 594497 SGTC_2283 7944793 200 µM 1.01592060578644 0.142013020501839 no 551 0.154833597761395 774 2970533 SGTC_616 4092-0450 108 µM 1.01528221819692 0.142163181854998 no 552 0.154985659096409 826 787165 SGTC_1902 st060212 70.5 µM 1.01365784372661 0.142545751195099 no 553 0.155373023099506 792 688944 SGTC_793 0488-0545 106 µM 1.01343974119301 0.142597171224102 no 554 0.155425082541416 784 292548 SGTC_2890 9046729 58.44 µM 1.0114081047538 0.143076754037802 no 555 0.155910571840355 724 903329 SGTC_3043 9092303 49.47 µM 1.01113064379531 0.14314233522417 no 556 0.155976952704633 720 25236084 SGTC_770 0389-1121 67.2 µM 1.01099915492922 0.143173421266907 no 557 0.156008417129267 838 6753108 SGTC_3259 9138485 49.47 µM 1.00750486574385 0.144001197314715 no 558 0.156846110325877 857 17646153 SGTC_761 k216-0224 480 µM 1.00683814924062 0.144159504387169 no 559 0.15700627927133 868 1340404 SGTC_2312 7706453 155.7 µM 1.00586996243844 0.144389602276852 no 560 0.157239063570594 759 976098 SGTC_753 1322-0200 289 µM 1.00512104757366 0.1445677579992 no 561 0.15741928318255 813 5403907 SGTC_747 3448-8087 38.7 µM 1.00502189210111 0.144591356710231 no 562 0.15744315422676 806 5168703 SGTC_2962 9082311 13.18 µM 1.00328627333313 0.145004849153221 no 563 0.157861378582322 733 16459453 SGTC_1278 0874-0585 172 µM 1.00298655802768 0.145076333606365 no 564 0.157933673452506 806 766306 SGTC_213 1246-0773 967 nM 1.00129669584479 0.145479822827762 no 565 0.158341694925576 818 6251622 SGTC_2630 antimycin a 100 µM 0.998139964208998 0.146235577224109 no 566 0.159105746716264 843 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_855 0428-0020 25 µM 0.997437905519581 0.146404015144595 no 567 0.159275999975918 728 6812414 SGTC_3035 9091303 49.47 µM 0.992970799343001 0.147478813602261 no 568 0.160362092503767 812 25237002 SGTC_1235 benzylparaben 21.5 µM 0.992439524284993 0.147606990753899 no 569 0.160491583271196 766 7180 SGTC_2045 5106652 78.05 µM 0.989622456450066 0.148287892307814 no 570 0.161179344754856 825 673349 SGTC_2324 6149169 200 µM 0.9879420045929 0.148695066212457 no 571 0.161590526086456 779 2888231 SGTC_2000 st075254 36.4 µM 0.983509504498663 0.149772644502878 no 572 0.162678369908517 800 17234175 SGTC_1119 parthenolide 318.541 nM 0.98343586615157 0.149790590487473 no 573 0.162696482694844 877 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.982735178170595 0.149961422943561 no 574 0.162868896180203 846 3256 An antibiotic and ribosome inhibitor. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.981810051107098 0.150187174091689 no 575 0.163096717768423 887 688788 SGTC_1503 4585-0012 61.3 µM 0.978650549857922 0.150959868255345 no 576 0.163876336653271 811 2922052 SGTC_769 0302-0231 76 µM 0.976948434987134 0.151377235717029 no 577 0.164297340653896 898 571869 YER009W NTF2 SGTC_1317 1273-0028 910 nM 0.97665701876895 0.151448769360572 no 578 0.164369490289257 842 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1251 0490-5699 265 µM 0.976473546548478 0.151493817628825 no 579 0.164414925385893 895 3883818 SGTC_2785 7756463 72.73 µM 0.969648925672235 0.15317580837368 no 580 0.166110758392258 833 2201551 SGTC_2586 curcumin 80 µM 0.968457953300392 0.153470597979175 no 581 0.166407854163984 915 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1615 st002656 86.5 µM 0.96774227895526 0.153647922393484 no 582 0.166586548689438 830 1584458 SGTC_3050 9093513 49.47 µM 0.966335592103568 0.15399685591076 no 583 0.166938140817914 848 25236664 SGTC_1837 st055472 66.5 µM 0.965339456168197 0.154244267724763 no 584 0.167187407698501 852 676091 SGTC_2755 lomerizine 42.69 µM 0.962546847197337 0.154939273084736 no 585 0.167887491326738 846 3949 A calcium channel blocker. SGTC_468 gf-109203x 121 µM 0.961729952153113 0.155142966709999 no 586 0.168092636304224 721 2396 A protein kinase C inhibitor. SGTC_2620 irigenin 100 µM 0.961624368238097 0.155169307064654 no 587 0.168119163117051 862 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1129 3453-1384 223 µM 0.95938584235518 0.155728454023838 no 588 0.168682202322397 878 1084452 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.959313155746663 0.155746632187966 no 589 0.168700504918288 904 91467 include heat shock SGTC_1979 st071809 45.3 µM 0.959254266641541 0.155761360766126 no 590 0.168715334218216 864 4976333 SGTC_207 4185-0010 4.486 µM 0.959207046842734 0.155773171432401 no 591 0.168727225589219 935 3761753 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.95678342919469 0.156380162220099 no 592 0.169338288921584 873 688751 SGTC_2489 cantharidin 73.42 µM 0.954245678211171 0.157017404792765 no 593 0.169979648933621 828 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_282 k297-0036 65.7 µM 0.953181162764264 0.157285218014204 no 594 0.170249144466196 824 5061378 SGTC_1472 k841-0093 193 µM 0.95067422732458 0.15791710424625 no 595 0.170884887609943 895 X1472 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.949611351496071 0.158185510159497 no 596 0.171154884208583 841 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1602 st001878 87.6 µM 0.9483940286935 0.158493285859994 no 597 0.171464449092141 858 595405 YLR310C CDC25 SGTC_2537 larixol 68.93 µM 0.947454104215358 0.158731195477226 no 598 0.171703716305477 904 6708759 SGTC_971 1315-0384 26.7 µM 0.945114435893782 0.159324418386674 no 599 0.172300228054808 823 6769120 SGTC_595 3909-8003 73.7 µM 0.941733513826345 0.16018421254792 no 600 0.173164546065097 857 699517 SGTC_963 1269-2853 151 µM 0.941245077432285 0.160308675917472 no 601 0.173289640593052 828 3668223 SGTC_1603 st002045 67.8 µM 0.93945217692203 0.160766084507905 no 602 0.173749317407455 889 5887985 SGTC_1158 4092-0494 91.8 µM 0.93712181594182 0.16136188357256 no 603 0.174347950368573 906 1148199 SGTC_2653 dihydrofissinolide 100 µM 0.936299959014157 0.161572349261649 no 604 0.17455938463348 867 6857746 SGTC_1351 1496-0003 46.5 µM 0.935577896445605 0.161757406673902 no 605 0.174745279712091 904 3891978 SGTC_2450 5739737 12.93 µM 0.935423902110137 0.161796891744975 no 606 0.174784941821915 810 2262825 SGTC_75 0159-0059 199.013 µM 0.935319391617865 0.161823692439217 no 607 0.174811862343467 849 5377270 SGTC_1140 3229-1848 2.98 µM 0.927653756794603 0.163797355778918 no 608 0.176793601564801 896 2849525 SGTC_1169 aniline yellow 25.8 µM 0.925706136669962 0.164301286229999 no 609 0.177299358930539 854 6051 A DNA damaging agent. SGTC_369 0957-0393 4.5 µM 0.92419274445705 0.164693557138309 no 610 0.177692986272068 823 6997992 SGTC_407 eburnamonine 100 µM 0.923636085377724 0.164837995556239 no 611 0.177837909701282 824 3195 SGTC_1231 0242-0792 125 µM 0.922893177305183 0.165030888475745 no 612 0.178031438239517 875 3707635 SGTC_715 0868-0130 184 µM 0.918848043540068 0.166083753350099 no 613 0.179087529541552 883 2876258 SGTC_2645 abamectin 100 µM 0.918778780967561 0.166101818677413 no 614 0.179105646657148 866 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3005 9076496 71.4286 µM 0.918657611721029 0.166133425553669 no 615 0.179137343852571 875 21368410 SGTC_3029 9088683 49.47 µM 0.918431043092475 0.166192536177089 no 616 0.179196622402578 883 25236615 SGTC_1418 3966-3099 2.4 µM 0.908740878466351 0.168733363014908 no 617 0.181743460380313 906 740335 SGTC_1023 4482-3888 16 µM 0.90717286404872 0.169146841448295 no 618 0.18215769561184 896 3303168 SGTC_1117 retinoic acid 1.10837 µM 0.906238203986799 0.169393616375746 no 619 0.182404892933459 960 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1216 1165-0504 9.65 µM 0.905805485812382 0.169507943606884 no 620 0.18251940844919 924 6304004 SGTC_3172 9105863 49.47 µM 0.904636974096099 0.169816920046885 no 621 0.182828870323466 866 2348785 SGTC_1884 5633444 25 µM 0.901598308440835 0.170622089771106 no 622 0.183635144962534 910 5724239 SGTC_2855 9016525 58.44 µM 0.90138995901656 0.170677386501177 no 623 0.183690509109883 934 43811474 SGTC_2178 5812956 200 µM 0.900974972202391 0.170787559756332 no 624 0.183800813452222 925 5403383 SGTC_2505 galangin 7.89 µM 0.900411718820958 0.170937168525758 no 625 0.18395059333912 835 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2250 alverine citrate 130 µM 0.900245145193482 0.170981429105727 no 626 0.183994903022631 935 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2888 9058547 12.99 µM 0.899002659243917 0.171311803561987 no 627 0.184325622105078 819 16476514 SGTC_1994 st072947 40.9 µM 0.89895779637432 0.171323740135387 no 628 0.1843375704078 904 5286565 YDL195W SEC31 SGTC_547 1120-0019 610 nM 0.895879533951827 0.172144036900261 no 629 0.185158552935823 889 3676939 SGTC_1820 st053765 18.6 µM 0.893473843693744 0.172786848299502 no 630 0.185801736639276 891 3690829 SGTC_867 0518-0118 155 µM 0.892237124862147 0.173117899843181 no 631 0.186132923597336 952 6848158 SGTC_1520 flindersine 88 µM 0.891324239293877 0.173362524949998 no 632 0.186377624241767 955 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2130 NSC 7 2.4545 µM 0.891301201757302 0.17336870114293 no 633 0.186383802072493 958 21448 SGTC_3101 9120531 49.47 µM 0.889638881895952 0.173814726469197 no 634 0.186829910667008 932 24824904 SGTC_148 3253-0744 288.01 µM 0.887915574344571 0.174277885475961 no 635 0.187293083224212 925 6893655 SGTC_2358 9037157 4 µM 0.887483600464086 0.174394106309023 no 636 0.18740929582871 915 2388925 SGTC_586 0957-0265 8.15 µM 0.886779388571381 0.174583677214518 no 637 0.187598843321165 849 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2872 9044037 25.97 µM 0.885982138703822 0.174798451424972 no 638 0.18781357605831 924 6465195 SGTC_3338 9144300 39.5675 µM 0.884935970811863 0.175080536930889 no 639 0.188095583011809 920 4901274 SGTC_1971 st069429 63.5 µM 0.88417698474927 0.175285368256549 no 640 0.188300340192931 961 1246522 YGL099W LSG1 SGTC_2572 astragaloside iv 100 µM 0.884020992957653 0.175327485350847 no 641 0.188342440260412 901 45006101 An anti-inflammatory agent. SGTC_2642 cholecalciferol 100 µM 0.883310805269333 0.175519313982668 no 642 0.188534183663589 931 9821465 A vitamin D precursor, similar to steriods. SGTC_1511 0906-3109 28.5 µM 0.882533071526872 0.175729540005092 no 643 0.188744301840336 1029 2882180 SGTC_1746 st038117 42 µM 0.881000054534425 0.176144390437406 no 644 0.189158895236814 911 2898218 SGTC_276 colchicine 750 µM 0.877827171676112 0.177004973110079 no 645 0.190018758252866 953 2833 A microtubule depolymerizer. SGTC_2815 7968870 71.43 µM 0.877587094110738 0.177070197408995 no 646 0.190083917786135 941 2977326 YHR190W ERG9 SGTC_1958 st076513 41.9 µM 0.872511543145497 0.178452676049562 no 647 0.191464686860103 962 732122 YGL099W LSG1 SGTC_795 0685-0265 78 µM 0.871886510337116 0.178623391484987 no 648 0.191635146752449 985 302754 SGTC_2248 tofa 1.1 µM 0.869862104511439 0.179177023846664 no 649 0.192187883538127 917 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1882 5615643 20 µM 0.869389199850114 0.179306508665084 no 650 0.192317144184909 908 2253075 SGTC_1191 1487-1166 10.6 µM 0.869097114675367 0.179386513149027 no 651 0.192397007378186 1044 3955771 SGTC_1363 1636-0063 10.4 µM 0.86775613642846 0.179754105885878 no 652 0.192763923660335 978 6072185 SGTC_2941 9056145 11.23 µM 0.866739754118939 0.180033034504174 no 653 0.193042309149011 867 2119517 SGTC_1335 1486-0900 202 µM 0.866200119641794 0.180181238277099 no 654 0.193190213886987 980 X1335 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.865826325822009 0.180283940894394 no 655 0.193292705029032 795 6708630 An antioxidant. SGTC_2909 7941780 10.49 µM 0.864538452336778 0.180638074919352 no 656 0.193646083218716 967 1243215 SGTC_1262 0737-0114 49.6 µM 0.862829918264243 0.181108553115362 no 657 0.194115493536626 1024 765919 SGTC_2296 7971656 126.45 µM 0.862319143059923 0.181249353951559 no 658 0.194255960683828 939 666570 SGTC_545 4218-0007 221 µM 0.860793617700926 0.181670289886611 no 659 0.194675860382863 908 2840508 SGTC_1060 3448-7350 82 µM 0.859294417852212 0.182084557297138 no 660 0.195089051565057 935 570178 SGTC_3020 9089140 49.47 µM 0.857192470377113 0.182666372928596 no 661 0.195669261547482 1001 17217859 SGTC_3096 9117468 49.47 µM 0.856173200739544 0.182948922560143 no 662 0.195950991873619 872 41316311 SGTC_34 0469-0683 81.75 µM 0.854814017068009 0.183326123129269 no 663 0.196327058507596 976 3690923 SGTC_2612 dictamnine 15.46 µM 0.85410919947431 0.183521914855103 no 664 0.196522243576191 918 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2075 5212009 200 µM 0.853290976086384 0.18374937305277 no 665 0.196748981522479 890 780898 SGTC_2251 lansoprazole 556 µM 0.851084524061362 0.184363620255555 no 666 0.197361200800939 803 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1387 3342-1166 1.8 µM 0.850963820068134 0.184397259472272 no 667 0.197394725471665 906 3418228 SGTC_365 0121-0052 13.6 µM 0.848675335096752 0.185035763859387 no 668 0.198030987225947 989 3101739 SGTC_2793 7325131 81.82 µM 0.847106930168452 0.18547415281734 no 669 0.198467761341866 930 4176441 SGTC_3125 9127534 49.47 µM 0.84610068968673 0.185755748909049 no 670 0.198748288016979 880 1639235 SGTC_1891 st059073 26.2 µM 0.84539877519949 0.185952336399089 no 671 0.198944114061961 1056 688754 SGTC_675 1309-0189 238 µM 0.842073367509625 0.18688544647575 no 672 0.199873443799568 949 4246530 SGTC_244 nsc-207895 1.295 µM 0.840904982438921 0.187213982241261 no 673 0.200200583476825 864 42640 SGTC_2687 chenodiol 100 µM 0.839675932895151 0.1875599613051 no 674 0.200545055832579 938 5702181 A cholesterol synthesis inhibitor. SGTC_2191 5911152 200 µM 0.838791390610822 0.187809205448337 no 675 0.200793191391657 990 2875902 SGTC_1006 4099-6547 255 µM 0.837850608397611 0.188074521101303 no 676 0.201057305721681 974 3146833 SGTC_477 mead ethanolamide 10 µM 0.837572405241737 0.188153023147132 no 677 0.201135448121804 863 16061185 SGTC_96 0929-0093 37.281 µM 0.837554286760666 0.18815813643537 no 678 0.201140537917841 938 6991579 SGTC_2479 5617353 43.85 µM 0.836452161062208 0.188469332935147 no 679 0.201450289398405 968 2731746 SGTC_1147 3809-1045 12.3 µM 0.836445698824306 0.188471158549849 no 680 0.201452106447381 969 325925 SGTC_3026 9090633 49.47 µM 0.835041081225644 0.188868228855877 no 681 0.201847289194155 1020 25236842 SGTC_1196 1588-0294 184 µM 0.834780368970945 0.18894198608632 no 682 0.20192069043445 935 6144269 SGTC_155 k072-0202 43.6 µM 0.832984142815476 0.189450632571905 no 683 0.202426836239566 973 5857737 SGTC_3346 9158254 43.5805 µM 0.830811370166572 0.19006703261505 no 684 0.2030400992 971 17639500 SGTC_3086 9117350 49.47 µM 0.830736051684618 0.190088422009372 no 685 0.20306137764389 967 2679265 SGTC_3225 9130819 49.47 µM 0.829086714221843 0.190557181562021 no 686 0.203527670520964 1005 4547121 SGTC_3351 9150312 21.596 µM 0.828293584699511 0.190782850022133 no 687 0.20375212755799 977 4904905 SGTC_2820 7989630 71.43 µM 0.827111596677602 0.191119464210398 no 688 0.204086905925485 902 2984098 SGTC_2413 inermin 26.06 µM 0.826032811072677 0.191427005401988 no 689 0.204392739749266 1022 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_194 1486-1323 56.904 µM 0.823325807660097 0.19220005456693 no 690 0.205161370693421 1022 5178754 SGTC_1391 3442-0225 151 µM 0.823306447819935 0.192205590098288 no 691 0.205166873936501 964 5227075 SGTC_822 1487-0950 154 µM 0.821778672009061 0.192642732319652 no 692 0.205601437203233 1019 1958375 SGTC_716 1683-5115 658 µM 0.821620776097642 0.192687945665772 no 693 0.205646380529316 1083 723597 SGTC_1519 esterone 74 µM 0.821348286755946 0.192765987983126 no 694 0.205723955322817 985 698 A steroid. SGTC_2617 dihydrotanshinone i 20.83 µM 0.821138452382724 0.192826098762334 no 695 0.205783704752801 1043 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2027 5150920 200 µM 0.81962697595965 0.193259426228648 no 696 0.206214395260489 1018 786715 SGTC_2949 9072542 2.23 µM 0.819510525966965 0.193292836093632 no 697 0.206247599478997 1047 16457352 SGTC_3228 9131799 49.47 µM 0.817619938320793 0.193835744590049 no 698 0.206787119493171 969 17015818 SGTC_872 0588-0139 234 µM 0.81746384833337 0.193880609497027 no 699 0.206831700449343 1056 2047100 SGTC_218 alverine citrate 93.75 µM 0.817344624739431 0.193914882168497 no 700 0.206865755804529 982 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_565 1418-0001 44.5 µM 0.816141035717523 0.19426107924697 no 701 0.207209738119128 1054 2862145 SGTC_2485 5633444 17.78 µM 0.815983481098546 0.194306425673401 no 702 0.207254791807203 982 5724239 SGTC_3106 9121286 49.47 µM 0.814266712377167 0.194800953405943 no 703 0.207746087472637 994 15943471 SGTC_433 pimozide 108 µM 0.814174194715476 0.19482762551386 no 704 0.207772583201809 978 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2583 asiatic acid 100 µM 0.813647064299128 0.194979635406995 no 705 0.207923583859708 1018 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1763 st044482 94.5 µM 0.813120870749132 0.19513144703059 no 706 0.208074380750068 1022 88505 SGTC_7 0192-1582 4.227 µM 0.812820292150009 0.195218198921233 no 707 0.208160549722413 1078 252616 SGTC_2341 7987486 176.74 µM 0.811896716529001 0.195484904534294 no 708 0.208425449343648 1065 1258686 SGTC_326 k292-0812 17.5 µM 0.809685599075478 0.196124318603214 no 709 0.209060448422342 1031 3579357 SGTC_846 0335-0850 148 µM 0.808235714420323 0.196544286024263 no 710 0.209477450852093 1019 6819598 SGTC_617 3770-0098 35 µM 0.807749619819303 0.196685207991465 no 711 0.209617366348823 986 5962639 SGTC_1274 0865-0114 173 µM 0.807388367333161 0.196789977054712 no 712 0.209721383390362 1030 870624 SGTC_1171 0368-0077 21.4 µM 0.807249456874036 0.196830272328806 no 713 0.209761388576541 979 3239779 SGTC_2677 mitomycin C 100 µM 0.807235186785188 0.196834412092306 no 714 0.209765498510834 1027 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2197 6588183 93.1375 µM 0.806504487417118 0.197046458987369 no 715 0.209976010815522 1006 884136 SGTC_1905 st060207 84.5 µM 0.805888235542715 0.197225400967504 no 716 0.210153647602254 1006 1948547 SGTC_462 ag-879 158 µM 0.805723285109764 0.197273314545802 no 717 0.210201210120874 1072 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2477 5967686 25.23 µM 0.804125800243053 0.197737704313119 no 718 0.210662162796932 1035 776118 SGTC_888 0916-0002 6.97 µM 0.796789797567261 0.199878753473721 no 719 0.212786560688265 1061 2802138 YIL048W NEO1 SGTC_1212 0520-0165 585 µM 0.796738939594623 0.199893645124795 no 720 0.212801331922177 1021 5403258 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.796164182052505 0.200061985442202 no 721 0.212968306605387 1031 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2502 avocadyne acetate 18.59 µM 0.793877302399902 0.200732631653568 no 722 0.213633432252998 1099 3952079 SGTC_3221 9128209 49.47 µM 0.793626194659558 0.20080635318981 no 723 0.213706539144559 1006 16460723 SGTC_854 0422-0053 192 µM 0.792477350981502 0.201143843959386 no 724 0.214041196472744 1084 3596728 SGTC_2773 thioridazine 9.09 µM 0.792019263788653 0.201278509026215 no 725 0.214174721952157 1103 5452 An antipsychotic. SGTC_2310 7668677 200 µM 0.790425837011174 0.201747353606371 no 726 0.214639559064022 1043 2197143 SGTC_2401 5128683 200 µM 0.790239896149503 0.201802106806 no 727 0.214693840219462 1025 708373 SGTC_2255 7941087 197.44 µM 0.789727925630289 0.201952910517663 no 728 0.214843339445629 1107 935561 SGTC_784 4579-0127 173 µM 0.787403575082749 0.202638408547278 no 729 0.215522827297207 1102 1948547 SGTC_2060 5238662 140 µM 0.786787199550814 0.202820423186769 no 730 0.21570322399345 1004 790130 SGTC_910 3454-3003 490 µM 0.78651839704301 0.202899830682671 no 731 0.215781922729218 1042 820824 SGTC_1640 st009078 66.4 µM 0.784458028551783 0.203509104770067 no 732 0.21638570017202 1009 690618 SGTC_630 4356-0227 183 µM 0.783955893577041 0.203657756939697 no 733 0.216532995578972 1071 779312 SGTC_2472 5377652 49.4 µM 0.783533496678708 0.203782853553348 no 734 0.216656945668375 1048 1610903 SGTC_1343 1487-0095 224 µM 0.781372403098379 0.204423597050475 no 735 0.217291748685611 1066 4560101 YGL055W OLE1 SGTC_1697 st025554 27.742 µM 0.780519134563255 0.204676912829052 no 736 0.217542684608326 1071 1269519 SGTC_2772 vinpocetine 57.06 µM 0.779551361988879 0.204964448109851 no 737 0.217827497109483 1045 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1926 methyl fluorone black 53.6 µM 0.779430372978083 0.205000412081096 no 738 0.217863118922731 961 72721 Reacts with homocysteine. SGTC_1306 1185-0270 9.02 µM 0.777291643937012 0.205636768098357 no 739 0.218493361940485 1089 1548076 SGTC_1735 st034310 56.75 µM 0.777023519128964 0.205716628405003 no 740 0.218572447245967 1032 871153 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.776966892831772 0.205733496760466 no 741 0.218589151679809 1003 5711223 A potent inhibitor of glutathione S-transferases. SGTC_414 piperonyl butoxide 100 µM 0.7757592297004 0.206093441806818 no 742 0.218945580342812 1073 5794 A potent inhibitor of cytochrome P450. SGTC_83 0170-0301 39.027 µM 0.775588211971802 0.206144443956198 no 743 0.218996081377899 1028 3089716 SGTC_764 1951-2361 146 µM 0.774438958944398 0.206487376608232 no 744 0.219335626173779 1041 5438930 SGTC_2137 5261020 140 µM 0.773519181932232 0.206762077828819 no 745 0.219607590502832 1067 763655 SGTC_2127 5253358 187.912 µM 0.772231008402062 0.207147168090222 no 746 0.219988809539212 1026 20612 SGTC_408 cantharidin 100 µM 0.772206942256385 0.207154366526996 no 747 0.219995935228781 1050 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_811 0416-0114 265 µM 0.771009108785792 0.207512838015507 no 748 0.220350766268921 1069 6612453 SGTC_1921 5740136 50 µM 0.770426412992553 0.207687351843295 no 749 0.220523495249915 1097 1774243 SGTC_2895 9054447 58.44 µM 0.767680941897024 0.20851076955217 no 750 0.221338380672689 1100 2697450 SGTC_2905 7799065 20.05 µM 0.76747241291937 0.208573389819174 no 751 0.221400344606394 1053 1296806 SGTC_355 1311-2252 105 µM 0.766359088008345 0.208907903600986 no 752 0.221731334484013 1051 5338538 SGTC_1682 st012968 530 nM 0.765772874892464 0.209084166341043 no 753 0.221905728346614 1028 24207270 SGTC_1201 1889-3372 45.9 µM 0.765546886498056 0.209152139981929 no 754 0.221972979057233 1041 5392199 SGTC_1936 st074407 74.3 µM 0.765139128071114 0.209274820009991 no 755 0.22209435120327 1142 809813 SGTC_2353 9059630 146.67 µM 0.76471234961479 0.209403267843021 no 756 0.222221425358006 1103 4779114 SGTC_2378 9074213 121.43 µM 0.760411578557667 0.210700261236824 no 757 0.223504302204033 1118 657714 SGTC_800 3448-7362 155 µM 0.758721600151624 0.211211198874287 no 758 0.224009556442432 1219 15991913 SGTC_3201 9113999 49.47 µM 0.758095320668759 0.211400728560036 no 759 0.224196960400991 1046 16649224 SGTC_2384 9036245 200 µM 0.757643860765001 0.211537414713047 no 760 0.224332107643198 1108 6462766 SGTC_1005 4092-0690 4.4 µM 0.757061880025313 0.211713694300819 no 761 0.224506395299181 1061 1529343 SGTC_133 0724-0033 378.92 µM 0.756810735984558 0.211789791351348 no 762 0.224581629943497 1031 280309 SGTC_843 0310-0051 143 µM 0.755038979959157 0.212327090842464 no 763 0.225112797039667 1110 2065037 SGTC_578 3460-0051 92 µM 0.75449339141254 0.212492705308496 no 764 0.225276506058737 1180 2876744 SGTC_1632 st005650 90 µM 0.754328843161717 0.212542669058396 no 765 0.22532589355325 1080 2759605 SGTC_11 0438-0307 1.3 µM 0.754221700636567 0.21257520571085 no 766 0.225358054594872 1100 4011476 SGTC_259 usnic acid 108.925 µM 0.74784458889874 0.214517017661367 no 767 0.227276951754535 1165 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_288 1315-0019 35.1 µM 0.747620956432365 0.214585299730632 no 768 0.22734441029848 1124 6811474 SGTC_387 norethindrone acetate 66.7 µM 0.74378267586129 0.215759216077339 no 769 0.228503981280194 1073 541197 SGTC_260 nsc-65238 3.989 µM 0.743460971925968 0.215857776191928 no 770 0.228601320931624 1095 3246252 SGTC_3002 9075603 71.4286 µM 0.742203056576649 0.216243412849898 no 771 0.228982158472257 1144 20105405 SGTC_2526 patulin 37.61 µM 0.741163430417408 0.216562429865911 no 772 0.229297176823467 1142 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1871 st057448 67.3 µM 0.739970670630069 0.216928772249573 no 773 0.229658895477889 1185 691747 SGTC_1001 4048-4355 44.4 µM 0.739385944537626 0.217108494878012 no 774 0.229836337333375 1123 21824233 SGTC_50 0929-0078 56.389 µM 0.738213343515559 0.217469167099826 no 775 0.230192407795976 1029 1377751 SGTC_1652 st011932 78 µM 0.737648515760407 0.217643021912067 no 776 0.230364032692096 1106 1551076 SGTC_1750 st081859 2.357 µM 0.737376943017471 0.21772664094345 no 777 0.230446576485831 1175 5291695 SGTC_210 3551-0445 56.827 µM 0.73681776811853 0.217898872925871 no 778 0.230616588228217 1151 2865180 YOR207C RET1 SGTC_2218 6965428 192.983 µM 0.735001927704047 0.218458713161031 no 779 0.231169160055735 1132 675684 SGTC_1063 disulfiram 1.84 µM 0.731108540209001 0.219661868267754 no 780 0.232356429144693 1150 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1917 st066507 28.5 µM 0.730462556949575 0.219861860801756 no 781 0.232553746088737 1115 3156428 SGTC_2614 arthonioic acid 13.39 µM 0.728237361478517 0.220551567411441 no 782 0.233234149403047 1114 6710684 SGTC_3137 9097352 49.47 µM 0.725483660738299 0.221406799812366 no 783 0.234077682573645 1243 44120435 SGTC_2988 9073640 71.4286 µM 0.724613974257119 0.221677296745894 no 784 0.234344441762816 1149 9102229 SGTC_1221 2958-7315 257 µM 0.72405148582106 0.221852346968763 no 785 0.234517063564561 1146 4562705 SGTC_974 1326-0144 138 µM 0.72136492472303 0.222689511290938 no 786 0.23534251051742 1176 5411856 SGTC_540 1187-0821 17.3 µM 0.72102414432255 0.222795831042272 no 787 0.235447329927888 1139 847520 SGTC_2549 cedrol 20.94 µM 0.720111655827021 0.223080659828747 no 788 0.235728125773874 1099 6708665 A sedative which affects the nervous system. SGTC_585 0kpi-0023 191 µM 0.718092869343758 0.223711550338302 no 789 0.236350013276092 1113 64601 SGTC_2803 7707263 71.43 µM 0.717336753023651 0.223948104941325 no 790 0.236583167329163 1134 2199229 SGTC_3147 9097027 49.47 µM 0.71649228541653 0.224212468597478 no 791 0.236843714680715 1175 25236841 SGTC_2991 9074669 71.4286 µM 0.712290779957518 0.225530396188793 no 792 0.238142366129999 1173 17333109 SGTC_926 2268-1401 59.4 µM 0.712217412358993 0.22555344900921 no 793 0.238165078073218 1172 2931578 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.711585585139821 0.225752030514965 no 794 0.23836071794025 1164 97141 SGTC_2896 9052656 71.43 µM 0.710784569994408 0.226003929415114 no 795 0.238608871860876 1161 6469436 SGTC_2397 5161689 200 µM 0.707248731661264 0.227117757443022 no 796 0.239705959782739 1207 2259942 SGTC_2357 9067248 200 µM 0.706831378307421 0.227249432228574 no 797 0.239835636151798 1166 9150235 SGTC_1980 st071811 45.7 µM 0.70582377448286 0.227567508004159 no 798 0.240148867629691 1215 4974850 SGTC_3102 9121669 49.47 µM 0.702821891105031 0.228516613310985 no 799 0.241083376495869 1193 41905072 SGTC_3031 9088762 49.47 µM 0.701941174966856 0.228795490597816 no 800 0.241357924716138 1164 205253 SGTC_1479 0549-0158 134 µM 0.701157817415638 0.229043699906805 no 801 0.241602265728312 1244 5440202 SGTC_3208 9114115 49.47 µM 0.699241622673183 0.22965148849554 no 802 0.242200521370749 1157 650895 SGTC_2175 5807670 165.306 µM 0.697855198450932 0.2300918044148 no 803 0.24263387742852 1151 241186 SGTC_1284 0929-0043 16 µM 0.697616698024452 0.230167597604191 no 804 0.242708468054137 1166 1239883 SGTC_1347 1493-0251 600 nM 0.696955831845722 0.230377687601899 no 805 0.242915217727992 1207 3986378 SGTC_1976 st070609 63.5 µM 0.696912432176339 0.230391488149471 no 806 0.24292879849631 1147 682556 SGTC_600 1495-0418 41.6 µM 0.693466343818567 0.231488775087955 no 807 0.244008470016586 1208 5377768 SGTC_1265 0819-1001 68.8 µM 0.692183822176173 0.231897892234819 no 808 0.244410948478803 1210 3106768 SGTC_1340 1486-1359 257 µM 0.692022044083221 0.23194952711734 no 809 0.244461742762917 1171 4309068 SGTC_1798 st045719 60.953 µM 0.687142501563258 0.233509941142627 no 810 0.245996466763263 1158 3980186 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.686843221044166 0.233605836278836 no 811 0.246090765066251 1218 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_587 k089-0003 57 µM 0.686273835376649 0.233788338488025 no 812 0.24627022252059 1149 9659696 SGTC_2292 7671323 168.05 µM 0.686197432655164 0.233812833464354 no 813 0.246294308264128 1202 937504 SGTC_570 0987-0065 62.6 µM 0.685864017256213 0.23391974423742 no 814 0.246399431311462 1102 3104428 SGTC_1888 azatryptophan 97.5 µM 0.684860573947647 0.234241665080021 no 815 0.246715953510849 1173 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_76 0433-0009 400.328 µM 0.684789399066477 0.234264508444252 no 816 0.246738412901066 1180 2841569 SGTC_2606 farnesol 9.78 µM 0.682133253141761 0.235117871632023 no 817 0.247577347765449 1235 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2089 5281248 129.67 µM 0.680642902898655 0.235597440399653 no 818 0.24804873645391 1223 2737878 SGTC_3120 9124077 49.47 µM 0.679208940274254 0.236059373513874 no 819 0.248502741697734 1270 18774327 YGL155W CDC43 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.678055493160697 0.23643130391048 no 820 0.248868254323348 1197 2346 DNA damaging agent; causes G2/M arrest. SGTC_1325 1431-0015 227 µM 0.677493914209021 0.23661250239882 no 821 0.249046315033074 1176 1103340 SGTC_2699 st077704 54.6 µM 0.676585508356664 0.236905769380974 no 822 0.249334488125666 1223 645852 SGTC_2915 7971052 15.16 µM 0.676531764572898 0.236923126119329 no 823 0.249351542789107 1110 5741558 SGTC_978 1416-0512 87.4 µM 0.67649762341823 0.236934152484808 no 824 0.249362377218166 1249 6814003 SGTC_2163 5671233 125 µM 0.675932880002795 0.237116585223841 no 825 0.249541630434443 1273 701023 SGTC_1410 3909-8106 77.9 µM 0.675236679015311 0.237341589736649 no 826 0.249762703321412 1248 1039210 SGTC_1128 3448-9350 235 µM 0.674780039966527 0.237489234108277 no 827 0.249907761743262 1215 619386 SGTC_2355 9061122 103.12 µM 0.674692015392949 0.237517700747296 no 828 0.249935729243599 1209 5302957 SGTC_1574 spiramycin 23.7 µM 0.674393167050063 0.237614360547652 no 829 0.250030692860795 1242 6419898 An antibiotic and protein synthesis inhibitor. SGTC_787 4152-0075 138 µM 0.673551126428268 0.237886827044978 no 830 0.250298367037115 1239 9566539 SGTC_235 0330-0087 5 mM 0.673500636880748 0.237903169834741 no 831 0.250314421859188 1252 46494818 YHR062C RPP1 SGTC_911 3456-4043 236 µM 0.673301162712144 0.237967742969567 no 832 0.250377856609739 1289 914281 SGTC_2354 9060492 162 µM 0.672751581653045 0.238145701273187 no 833 0.250552672871285 1238 6471895 SGTC_1834 st055981 52.8 µM 0.67270848471671 0.238159659454265 no 834 0.250566384311408 1267 471719 YDL150W RPC53 SGTC_2853 9015042 58.44 µM 0.67063965114788 0.238830237644087 no 835 0.251225058214639 1188 6457456 SGTC_887 0885-0007 9.62 µM 0.670546772899068 0.238860366796324 no 836 0.251254650192948 1264 5719458 SGTC_1968 st069590 43.6 µM 0.670093295252435 0.239007502100115 no 837 0.251399159362926 1190 6384066 SGTC_1244 0416-0015 52.5 µM 0.668774910990006 0.239435546202273 no 838 0.251819536662287 1251 96201 SGTC_308 4092-1169 104 µM 0.668702013799848 0.23945922617737 no 839 0.251842791332834 1209 2268590 YDL196W YDL196W SGTC_1731 st035964 63 µM 0.668136301232969 0.239643036113386 no 840 0.252023295793662 1234 6739575 SGTC_1139 k015-0024 46.9 µM 0.668041554080024 0.239673828652405 no 841 0.252053533867529 1235 2766652 SGTC_2743 auranofin 4.32 µM 0.667744818096945 0.239770280922131 no 842 0.252148248036481 1191 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_517 1365-0151 113 µM 0.666329971437629 0.240230459518447 no 843 0.252600106236445 1276 768657 SGTC_766 1391-0721 126 µM 0.664805171582019 0.240726938736808 no 844 0.253087557227842 1252 1020919 YIL115C NUP159 SGTC_2819 7996655 46.38 µM 0.663376568875782 0.241192602097969 no 845 0.253544704315686 1147 6456960 SGTC_1693 xanthone 101.9 µM 0.660989986405578 0.241971616833826 no 846 0.254309367671916 1289 7020 An insecticide. SGTC_231 b-estradiol 524 µM 0.659636944555446 0.242413874556018 no 847 0.254743419977441 1194 450 A steroid. SGTC_1821 st053465 65.6 µM 0.659635337816755 0.242414399997752 no 848 0.254743935645516 1219 675086 SGTC_1124 fisetin 1.16336 µM 0.658882218054124 0.242660755970119 no 849 0.254985702692739 1256 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_773 4358-1457 44.6 µM 0.656752287437444 0.243358219123014 no 850 0.255670103878386 1273 1186886 SGTC_1210 3013-0140 750 nM 0.653336547959184 0.244478988813716 no 851 0.256769667729889 1282 905973 SGTC_1938 st074717 56.4 µM 0.65323404282358 0.244512665641021 no 852 0.256802703255918 1174 17250979 SGTC_475 α-linolenic acid 10 µM 0.650646856995315 0.245363481304535 no 853 0.257637237804428 1351 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2080 5212524 12.4 µM 0.650478585329607 0.245418873774246 no 854 0.257691565017893 1238 260183 SGTC_1333 1482-0047 286 µM 0.650420839893676 0.245437884240963 no 855 0.257710209744812 1240 3811116 SGTC_908 3448-7491 47.7 µM 0.649642733877239 0.24569412290952 no 856 0.25796151128491 1282 1203031 SGTC_2723 salbutamol 83.58 µM 0.649125946610335 0.245864385859556 no 857 0.258128486061647 1262 9884233 β2-adrenoceptor agonist SGTC_1236 0330-0013 258 µM 0.648813935616509 0.2459672129913 no 858 0.258229324427417 1253 4617066 SGTC_712 r015-0009 80.6 µM 0.647951411248948 0.24625158872616 no 859 0.258508188593675 1242 6813872 YLR060W FRS1 SGTC_1658 st012944 20 µM 0.645931941931068 0.246918100109237 no 860 0.25916171611342 1220 24207260 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.645748025695497 0.2469788482757 no 861 0.259221276293786 1245 6708760 SGTC_252 miconazole 1.30953 nM 0.645632398246411 0.247017044514637 no 862 0.25925872517811 1229 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2346 9031566 143.75 µM 0.645569288905197 0.247037893315233 no 863 0.259279165919556 1260 4771086 SGTC_457 grayanotoxin iii 135 µM 0.643999011416395 0.247556953152742 no 864 0.259788037523835 1233 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_845 0330-0138 4.51 µM 0.641679675949341 0.248324680887374 no 865 0.260540594049829 1269 9039800 SGTC_1414 3917-0015 5.4 µM 0.64077803377075 0.248623477477863 no 866 0.260833453255926 1259 6618702 SGTC_1496 4469-0713 57.4 µM 0.638374663749708 0.249420868636888 no 867 0.261614909828084 1268 746691 SGTC_2823 7987624 58.44 µM 0.638176204284239 0.249486774305491 no 868 0.261679492657444 1317 2239440 SGTC_2205 7238770 200 µM 0.636149621422936 0.250160304093955 no 869 0.262339452778459 1313 279867 SGTC_3113 9123498 49.47 µM 0.634465663788579 0.250720696006742 no 870 0.262888484122414 1331 8897275 SGTC_2644 guaiazulene 100 µM 0.634387392170917 0.250746759602884 no 871 0.262914017793407 1293 3515 A coloring agent. SGTC_174 3553-0389 74.3 µM 0.634025647867093 0.250867235151425 no 872 0.263032042045285 1284 738071 SGTC_2700 st077718 96.8 µM 0.63382440180604 0.250934271527446 no 873 0.263097713170926 1279 904970 SGTC_1374 2889-5571 141 µM 0.633116457831453 0.251170167600712 no 874 0.263328797803959 1295 2853281 SGTC_2768 sulfasalazine 50.2 µM 0.63305652901903 0.251190142037995 no 875 0.263348364317471 1371 5384001 An antioxidant and salicylic acid derivative. SGTC_2282 7944268 200 µM 0.632735049014573 0.251297306542951 no 876 0.263453338902293 1335 2970414 SGTC_3007 9078383 71.4286 µM 0.631544213902195 0.251694478774593 no 877 0.263842374670914 1276 6496995 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.631389871407006 0.251745979976528 no 878 0.26389281849289 1311 688761 SGTC_1846 st056244 14.8 µM 0.630761345367829 0.251955764808943 no 879 0.264098290684261 1327 5393182 SGTC_1991 st073000 8.92 µM 0.627784370065105 0.252950649871813 no 880 0.265072603232883 1368 4301969 YIL048W NEO1 SGTC_849 0386-0493 241 µM 0.627006714184365 0.253210877361742 no 881 0.265327417007319 1278 726119 SGTC_1194 1488-0194 225 µM 0.626627622677267 0.253337784020324 no 882 0.265451678629752 1307 1391452 SGTC_1022 4477-0945 21.3 µM 0.626189459151246 0.253484507583107 no 883 0.265595340127129 1293 4648966 SGTC_635 k038-0028 24.7 µM 0.62599639322337 0.2535491718636 no 884 0.265658653528294 1339 4035102 SGTC_2280 7785178 200 µM 0.625301256993518 0.253782068151079 no 885 0.265886677569868 1320 2954328 SGTC_929 2805-0021 398 µM 0.625235824738477 0.253803996153073 no 886 0.265908146277712 1358 3098024 SGTC_1877 wortmannin 25 µM 0.625133085188433 0.253838428779245 no 887 0.26594185750078 1291 312145 A covalent inhibitor of PI 3-kinase. SGTC_1263 0774-1208 64.8 µM 0.623756402979497 0.254300053133965 no 888 0.266393787584765 1347 906585 SGTC_94 0334-0113 514.748 µM 0.623504524024379 0.254384559922419 no 889 0.266476515130182 1257 6795178 SGTC_2719 novobiocin 32.65 µM 0.622990692344803 0.254556998933114 no 890 0.266645319152318 1337 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2140 5586273 200 µM 0.622289954771612 0.254792261165315 no 891 0.266875612615917 1304 854421 SGTC_3076 9116187 49.47 µM 0.621483308284716 0.25506322160735 no 892 0.267140836807118 1293 27241210 SGTC_2658 polymyxin b sulfate 77.05 µM 0.620522568156513 0.255386140178193 no 893 0.267456900285013 1280 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3051 9093778 49.47 µM 0.620220977131823 0.255487553303011 no 894 0.267556156324902 1318 17217378 SGTC_1715 st032160 10.2275 µM 0.619353914271989 0.255779229380721 no 895 0.267841617115976 1265 5289825 SGTC_2222 6885208 172.143 µM 0.618376275873812 0.256108310953262 no 896 0.268163666308253 1285 609514 SGTC_2305 7443522 69.23 µM 0.615162407489452 0.257191681046166 no 897 0.269223735631704 1298 5415886 SGTC_1268 0828-0275 2.46 µM 0.613464435396756 0.257765014705058 no 898 0.269784645838462 1360 745337 SGTC_2097 5376186 200 µM 0.613185553740032 0.257859244680936 no 899 0.269876827868785 1291 742755 SGTC_941 3237-0776 460 µM 0.613117935641432 0.257882094525768 no 900 0.269899180848073 1370 760008 SGTC_3223 9129970 49.47 µM 0.61294734295969 0.257939746723412 no 901 0.269955578960739 1384 17248386 SGTC_3191 9110352 49.47 µM 0.612113090664731 0.258221780521159 no 902 0.270231468532675 1339 17122424 SGTC_917 harmaline 728.087 nM 0.61174062883332 0.258347749450943 no 903 0.270354688213944 1353 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_156 3474-0145 5.642 µM 0.608631579041227 0.259400490516211 no 904 0.271384333972849 1275 2265471 SGTC_2618 avocadyne 43.43 µM 0.60636264623411 0.260170159797419 no 905 0.272136983610918 1296 3015189 SGTC_3064 1327-0027 10 µM 0.604887348186463 0.260671242386017 no 906 0.272626925066376 1245 16000455 YPR107C YTH1 SGTC_1689 st020265 53.493 µM 0.602653714540755 0.261430836597602 no 907 0.273369539429572 1387 5758320 YPR016C TIF6 SGTC_2616 abietic acid 100 µM 0.599210533617688 0.262603985413735 no 908 0.274516249659705 1351 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2797 7859098 81.82 µM 0.597063156440031 0.26333699400349 no 909 0.275232607600788 1354 972681 SGTC_2995 9067767 71.4286 µM 0.596533636595407 0.263517906389873 no 910 0.275409395011028 1347 11673567 SGTC_612 0302-0167 22.4 µM 0.596531458399868 0.2635186507093 no 911 0.275410122346636 1404 235821 SGTC_821 1114-0266 29.2 µM 0.594310090216653 0.264278280905302 no 912 0.276152365558775 1337 3123235 SGTC_2048 5246248 200 µM 0.591202333124827 0.265342893036056 no 913 0.277192429835928 1342 677046 SGTC_2862 9027634 71.43 µM 0.590361581805537 0.265631279558697 no 914 0.277474130690018 1305 5012562 SGTC_85 0868-0259 160.055 µM 0.589722803256803 0.265850493511837 no 915 0.277688252358215 1360 83173 SGTC_2801 7907800 81.82 µM 0.588402199781353 0.266303984449905 no 916 0.278131180785576 1369 6620925 SGTC_2648 atorvastatin 78.68 µM 0.58812334658788 0.266399791766941 no 917 0.27822475177324 1367 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3032 9089427 49.47 µM 0.58773404367493 0.2665335761395 no 918 0.278355410544401 1315 17173707 SGTC_350 k064-0020 19.8 µM 0.587301995320305 0.266682089799401 no 919 0.278500450645584 1411 2790705 SGTC_3063 1327-0034 4 µM 0.586585440171528 0.266928492908397 no 920 0.278741081781074 1264 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1159 4092-0538 61.2 µM 0.586267913892406 0.267037718001653 no 921 0.278847744737613 1399 717301 SGTC_1558 st069300 45.6 µM 0.586170568896651 0.267071207989818 no 922 0.278880448701582 1357 24208000 SGTC_1609 st001574 46.4 µM 0.586145718771228 0.267079757617614 no 923 0.278888797633209 1325 3960012 SGTC_777 1315-0167 517 µM 0.585789158451973 0.267202446579927 no 924 0.279008605094835 1315 4221767 SGTC_2464 5717415 7.67 µM 0.58553268722681 0.267290713437356 no 925 0.279094797199688 1293 5285744 SGTC_701 4424-0219 185 µM 0.58507852287282 0.267447054232723 no 926 0.279247459650641 1393 2911779 SGTC_2174 5790901 200 µM 0.584848551966102 0.267526236627471 no 927 0.279324777365818 1362 786020 SGTC_3146 9095609 49.47 µM 0.584392038387241 0.267683456039783 no 928 0.279478291011725 1417 17173999 SGTC_543 3844-1095 191 µM 0.583855007077064 0.267868464666846 no 929 0.279658933109349 1405 4230703 SGTC_824 1304-0008 100 µM 0.583619991799763 0.267949448271877 no 930 0.279738003403245 1372 768245 SGTC_922 1866-0035 480 µM 0.583322125161478 0.268052107457571 no 931 0.279838235462499 1412 3156169 SGTC_3159 9100096 49.47 µM 0.582542889062869 0.268320763356284 no 932 0.280100530606934 1302 25236875 SGTC_489 paxilline 115 µM 0.582137051194145 0.268460737003335 no 933 0.280237185030531 1312 105008 A toxic potassium channel blocker. SGTC_2953 9074162 66.49 µM 0.581758509041845 0.268591329430649 no 934 0.28036467749834 1401 16451992 SGTC_654 1124-0271 80.9 µM 0.577609113727629 0.270024910055028 no 935 0.281764026243115 1349 5403748 SGTC_2695 st077686 51.995 µM 0.576338242344842 0.270464749902065 no 936 0.282193289413524 1329 2876092 SGTC_1568 digitonin 820 nM 0.576125226197711 0.270538508343102 no 937 0.282265270826365 1463 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2125 5246583 200 µM 0.573921828428506 0.271302040432004 no 938 0.283010350525516 1428 835267 SGTC_394 menadione 8.33 µM 0.572809391711806 0.271687934982404 no 939 0.283386879687359 1367 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2656 pseudo-anisatin 100 µM 0.572251377921507 0.271881607930161 no 940 0.283575842382086 1376 6708809 A neurotoxin. SGTC_115 0527-0192 112.043 µM 0.570835839715115 0.272373214552506 no 941 0.284055463021957 1395 4233931 SGTC_621 3584-0052 32.1 µM 0.570143802777423 0.27261371479084 no 942 0.284290084026964 1391 2273927 SGTC_1386 3228-0095 33.8 µM 0.569555028158807 0.272818411730821 no 943 0.28448976894978 1433 870181 SGTC_134 0269-0018 6.916 µM 0.56825633772915 0.27327019167766 no 944 0.284930460965819 1334 4378915 SGTC_2186 6124449 200 µM 0.567856619454169 0.273409317607403 no 945 0.285066165145502 1394 3834182 YLR033W RSC58 SGTC_1990 st072050 59.8 µM 0.567685182708556 0.27346899862004 no 946 0.285124377286211 1366 17233948 SGTC_2969 9091408 28.7 µM 0.565806779548328 0.274123335419141 no 947 0.285762568646082 1350 4286311 SGTC_204 PMA1.184 62.41 µM 0.564378856842351 0.274621265463074 no 948 0.286248162448215 1393 2252213 YGL008C PMA1 SGTC_1505 k297-0037 20.6 µM 0.564209572801058 0.274680325962523 no 949 0.28630575685781 1365 4089396 SGTC_1428 4049-0204 61.7 µM 0.56376496063409 0.27483547387323 no 950 0.286457050562217 1458 X1428 SGTC_3072 9116419 49.47 µM 0.563624603073501 0.274884460769033 no 951 0.286504819650114 1345 17170162 SGTC_1056 3448-1962 115 µM 0.563356626165255 0.27497800068226 no 952 0.286596033015981 1421 715507 SGTC_1797 st048695 56.8 µM 0.562998363040561 0.275103080359396 no 953 0.286717999308965 1395 592262 YIL048W NEO1 SGTC_2858 9025781 8.96 µM 0.561559216440469 0.275605808861812 no 954 0.287208186954148 1404 4894980 YPL153C RAD53 SGTC_286 k060-0067 22.9 µM 0.560619811842154 0.275934208959542 no 955 0.287528371324968 1354 5985051 SGTC_737 1950-0117 57.9 µM 0.559779172247081 0.276228245332961 no 956 0.28781503588045 1379 5393513 SGTC_3058 9093861 49.47 µM 0.559536538259603 0.276313141700154 no 957 0.287897801031447 1415 17217477 SGTC_955 1216-0110 33 µM 0.559375686963773 0.276369429784997 no 958 0.28795267539125 1347 3619719 SGTC_269 exalamide 29 µM 0.557480690290769 0.277032985481422 no 959 0.28859952427633 1449 3316 A derivative of salicylamide. SGTC_749 1000-0129 128 µM 0.55702424500322 0.277192931704765 no 960 0.288755432129089 1500 708470 SGTC_2533 agelasine 13.65 µM 0.556633150735253 0.277330013743226 no 961 0.288889049595408 1501 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2594 a-mangostin 100 µM 0.555307925513828 0.277794763366978 no 962 0.28934202938007 1477 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2929 9013348 24.6 µM 0.554560969650821 0.278056884393363 no 963 0.289597495916419 1414 2995952 SGTC_2146 5545642 200 µM 0.554517926397496 0.278071992766229 no 964 0.289612220375122 1398 825326 SGTC_463 ikarugamyin 104 µM 0.554037943874034 0.278240495888239 no 965 0.289776439085501 1439 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1957 st077035 62.4 µM 0.552907034625586 0.278637710695468 no 966 0.290163535101049 1459 705593 SGTC_711 k292-0785 179 µM 0.552586169840333 0.27875045987459 no 967 0.290273407190424 1382 4146315 SGTC_3269 9137823 49.47 µM 0.552038747474126 0.278942870726919 no 968 0.290460903204491 1355 17682936 SGTC_381 3461-2219 42.7 µM 0.551696440810037 0.279063219271445 no 969 0.290578174446165 1452 2883159 SGTC_1397 3532-0190 20.1 µM 0.550461340698735 0.27949766688702 no 970 0.291001492906956 1411 5322280 SGTC_2244 6635614 200 µM 0.547364014611168 0.280588596552485 no 971 0.292064336350475 1407 836499 SGTC_2619 obliquin 87.91 µM 0.547252615960031 0.280627871359384 no 972 0.292102596294064 1428 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2141 5621638 7.665 µM 0.546052173538239 0.281051269073644 no 973 0.292515037001959 1492 2856238 SGTC_2249 haloperidol 116.36 µM 0.545405894740992 0.281279340239312 no 974 0.292737193560192 1430 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2602 kawain 100 µM 0.544052972802334 0.281757074195939 no 975 0.293202510268392 1385 5369129 SGTC_3311 9131146 2.8755 µM 0.543911830285409 0.281806935935882 no 976 0.293251073814912 1411 4900406 YPR165W RHO1 SGTC_2159 5658611 73.75 µM 0.543502471031987 0.281951575264526 no 977 0.293391944996885 1432 793844 SGTC_523 1934-0222 13.7 µM 0.543106451465591 0.282091535290889 no 978 0.293528255475324 1399 1361595 SGTC_360 0957-0399 1.01 µM 0.539120706982271 0.283502024346012 no 979 0.29490178423057 1494 6752301 YPR165W RHO1 SGTC_1610 st001799 48.1 µM 0.538796463868025 0.28361691712344 no 980 0.295013651924892 1382 621897 SGTC_1031 k035-0009 16 µM 0.538403272242458 0.283756271135097 no 981 0.295149333888351 1513 5180959 SGTC_3175 9106517 49.47 µM 0.537741688789532 0.283990821888832 no 982 0.295377696916036 1384 41468073 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.537250322615425 0.284165085633574 no 983 0.295547357538545 1393 5355888 SGTC_192 3455-0609 60.9 µM 0.536856578456769 0.284304764479912 no 984 0.295683343222166 1444 3769639 SGTC_3168 9103419 49.47 µM 0.535756716606713 0.284695108948818 no 985 0.296063349920909 1403 16649256 SGTC_1974 st069448 26.9 µM 0.534063858348637 0.285296409154404 no 986 0.296648676841652 1469 6323587 YNR016C ACC1 SGTC_2667 digitoxin 100 µM 0.533795668839583 0.285391725073329 no 987 0.296741455331489 1431 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2 0422-0095 29 µM 0.532984051610281 0.285680270330831 no 988 0.297022310160247 1313 6790840 SGTC_2188 6126565 140.678 µM 0.531405472980545 0.2862418820325 no 989 0.297568914864348 1456 874518 SGTC_1429 4049-0205 9.46 µM 0.530452474819233 0.286581184266078 no 990 0.297899125792417 1445 22774478 SGTC_1515 3460-0031 42.1 µM 0.530438667555461 0.286586101559153 no 991 0.297903911194393 1396 2876596 SGTC_1344 1488-0097 29.1 µM 0.529347907325356 0.286974689267553 no 992 0.29828206392908 1459 747966 SGTC_1786 berberine 21.6 µM 0.528359235501273 0.28732712306985 no 993 0.298625012616979 1398 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2030 5175110 200 µM 0.527852275972599 0.2875079193269 no 994 0.298800935333822 1498 2831986 SGTC_1717 st033143 58.0435 µM 0.526805133441495 0.287881530490989 no 995 0.299164458849361 1545 674616 SGTC_801 0866-0028 10.1 µM 0.526791953641555 0.287886234387346 no 996 0.29916903559627 1452 6849771 SGTC_3308 9128332 17.569 µM 0.526756359241442 0.287898938279688 no 997 0.299181396076269 1541 17332805 YDL196W YDL196W SGTC_2257 7960413 200 µM 0.526542850102435 0.287975146752516 no 998 0.299255543935678 1482 2974689 YIL048W NEO1 SGTC_3028 9087778 49.47 µM 0.52612155739913 0.28812554798007 no 999 0.299401875716722 1380 17217395 SGTC_2204 7233102 200 µM 0.525806587757676 0.288238016149873 no 1000 0.299511298444618 1445 2172480 SGTC_2866 9034245 58.44 µM 0.525629861176187 0.288301130077425 no 1001 0.299572702472947 1492 6462273 SGTC_342 k048-0088 23.3 µM 0.524170767442678 0.288822461469134 no 1002 0.300079885543361 1405 6820570 SGTC_531 3788-1495 174 µM 0.524112014514548 0.288843463068583 no 1003 0.300100316277859 1434 2896655 SGTC_2423 st077119 87.2 µM 0.523833478541941 0.288943037263983 no 1004 0.300197182895997 1387 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2052 5265182 7.135 µM 0.523163278592416 0.289182694100205 no 1005 0.300430316635229 1546 1239884 SGTC_1377 2944-0135 198 µM 0.52131363000502 0.289844594448511 no 1006 0.301074153777093 1510 1894137 SGTC_2754 granisetron 64.02 µM 0.519958152780392 0.290330105381346 no 1007 0.301546371148348 1538 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1608 st001473 40.5 µM 0.519024213626626 0.290664849359865 no 1008 0.301871928026026 1407 7292267 SGTC_507 nimesulide 162 µM 0.518036480867117 0.291019070431063 no 1009 0.302216408273288 1521 4495 A COX2 inhibitor. SGTC_444 curcumin 90.4 µM 0.517458577240825 0.291226411903919 no 1010 0.302418038875818 1460 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_107 0358-0022 2.6945 µM 0.513002399836073 0.292827519829523 no 1011 0.303974820992681 1526 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_525 k781-2675 26.7 µM 0.51126393393994 0.293453258154188 no 1012 0.304583127888821 1481 3651118 YDL195W SEC31 SGTC_2718 lomofungin 53.02 µM 0.510960361031028 0.293562588789262 no 1013 0.304689406649403 1538 5351222 A RNA synthesis inhibitor. SGTC_2111 5486399 200 µM 0.51038023095635 0.293771572886469 no 1014 0.304892551998027 1444 689674 SGTC_487 nimodipine 119 µM 0.507640118713647 0.294759590826183 no 1015 0.305852875029518 1474 4497 L-type voltage-gated calcium channels inhibitor SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.506130767687399 0.295304479772791 no 1016 0.306382426318546 1573 165506 SGTC_72 0744-0168 198.391 µM 0.506007167539914 0.295349121035854 no 1017 0.306425808999478 1515 677577 SGTC_1452 4194-0072 190 µM 0.505408733923654 0.295565304098422 no 1018 0.306635892861079 1585 1343545 SGTC_61 0978-8327 98.565 µM 0.504017531036911 0.296068154572895 no 1019 0.307124528829647 1482 6150059 YHR072W ERG7 SGTC_2114 5491910 81.25 µM 0.503875080180723 0.296119665606866 no 1020 0.307174581587093 1557 2849228 SGTC_1895 st058434 18.3 µM 0.503742337867976 0.29616766967789 no 1021 0.307221226301109 1549 5393175 SGTC_1390 3413-2614 145 µM 0.502351664823224 0.296670798165712 no 1022 0.307710086412423 1470 3421432 SGTC_2930 9013230 14.89 µM 0.501930763032934 0.296823152408237 no 1023 0.307858112435685 1560 2995857 SGTC_201 4262-0159 12.803 µM 0.501198628661369 0.297088249106648 no 1024 0.3081156696644 1540 1341029 SGTC_1483 3453-0561 55.9 µM 0.501019641005511 0.297153074763629 no 1025 0.308178650036574 1512 4546991 SGTC_2867 9039098 71.43 µM 0.499246202719578 0.297795726885275 no 1026 0.308802974604767 1453 6463460 SGTC_2356 9061756 188.97 µM 0.498462551894905 0.29807990523181 no 1027 0.309079028783757 1516 20104043 SGTC_1086 cerivastatin 2.18 µM 0.497541666544809 0.298414007290615 no 1028 0.309403563960828 1507 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2142 5622915 118.518 µM 0.496159233667604 0.298915880907883 no 1029 0.309891035253757 1469 5322196 SGTC_1579 chlormadinone acetate 49.4 µM 0.495929967643459 0.298999149899709 no 1030 0.309971911029855 1572 45114258 A steroidal progestin. SGTC_2281 7943571 200 µM 0.493989691874307 0.299704275834221 no 1031 0.310656729723781 1554 1244024 SGTC_1795 st049545 62.3 µM 0.493285721095773 0.299960295686825 no 1032 0.31090535807251 1529 5291882 SGTC_1280 0880-0253 10.1 µM 0.490979224375882 0.300799814119293 no 1033 0.311720570881384 1475 6836607 SGTC_2317 5986382 200 µM 0.489479016407156 0.301346427960557 no 1034 0.312251303379145 1633 877883 SGTC_1176 0848-0131 83.3 µM 0.488700072225277 0.30163041933311 no 1035 0.312527026326087 1569 6769040 SGTC_789 1309-1135 70.6 µM 0.488014067984803 0.301880625835334 no 1036 0.312769938255454 1461 3092424 SGTC_2381 9035592 200 µM 0.485506675325377 0.302795940137322 no 1037 0.313658489346309 1416 4749657 SGTC_2816 7982706 58.44 µM 0.485149979240018 0.302926251623381 no 1038 0.313784980678781 1469 2981853 SGTC_2662 daunorubicin 22.37 µM 0.485133397187617 0.302932310141437 no 1039 0.313790861527948 1452 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2315 7733312 200 µM 0.483903398303509 0.303381861030518 no 1040 0.314227214253926 1474 726316 SGTC_2202 7226349 200 µM 0.483623977273767 0.303484027842274 no 1041 0.314326377507996 1471 844334 SGTC_370 0180-0345 38.7 µM 0.483611764201751 0.303488493750133 no 1042 0.314330712090074 1488 3989527 SGTC_32 0928-0142 34.1 µM 0.483551404699714 0.303510565612 no 1043 0.314352134857958 1498 2244242 SGTC_1368 1852-0141 284 µM 0.483482393935053 0.303535801888538 no 1044 0.314376628894285 1479 2838987 SGTC_1531 st059297 52.4 µM 0.483282738760171 0.303608818285072 no 1045 0.314447497239696 1520 7566702 SGTC_1493 4348-0038 111 µM 0.483125901201045 0.303666181242547 no 1046 0.314503172109412 1548 800424 SGTC_2433 5607874 27.82 µM 0.482128791707435 0.30403098471313 no 1047 0.314857228941992 1456 2252428 SGTC_3306 9127676 59.7925 µM 0.481574663261896 0.304233803109142 no 1048 0.315054064258901 1497 41905287 SGTC_1211 1056-0033 32.3 µM 0.478840875518881 0.305235286634417 no 1049 0.316025917546636 1527 6741922 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.478370984125985 0.305407571769755 no 1050 0.316193090885391 1546 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_662 k832-1615 104 µM 0.478311852144131 0.305429255496941 no 1051 0.316214130943227 1566 5878478 SGTC_3153 9100258 49.47 µM 0.47823880364639 0.305456043359939 no 1052 0.316240123530569 1465 25236848 SGTC_1793 st048256 72.231 µM 0.477714813757056 0.305648228001253 no 1053 0.316426599602854 1471 672022 SGTC_1106 tegaserod maleate 11.7 µM 0.477465395025523 0.305739726538747 no 1054 0.316515378453009 1541 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3262 9137218 49.47 µM 0.476856027008588 0.305963322434068 no 1055 0.316732323192649 1454 17650664 SGTC_1782 st039423 80.636 µM 0.476137920080822 0.306226910825289 no 1056 0.316988061644489 1467 2068169 SGTC_1680 diphenhydramine 100 µM 0.475613701069007 0.306419394067434 no 1057 0.317174806284627 1506 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2714 st079313 56.9 µM 0.474745678601999 0.30673823285241 no 1058 0.317484127779237 1512 2939799 SGTC_250 brefeldin a 552.239 µM 0.474539033512555 0.306814158524924 no 1059 0.31755778495438 1451 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.471211008261505 0.308038083528727 no 1060 0.318745029157941 1531 6857784 SGTC_961 1252-1571 372 µM 0.470417582363134 0.308330192466479 no 1061 0.31902835242888 1636 6813498 SGTC_1555 citronellol 128 µM 0.468949232329922 0.308871102684361 no 1062 0.319552962239396 1617 8842 A terpine precursor. SGTC_2084 5306078 60.6385 µM 0.468720435232328 0.308955424252929 no 1063 0.319634739072409 1558 679340 SGTC_2246 7293507 91.5585 µM 0.468361056482984 0.309087891102651 no 1064 0.319763206204701 1655 887656 SGTC_1835 st008666 49.2 µM 0.467803494358011 0.309293457393795 no 1065 0.319962560751254 1469 690455 SGTC_2331 7980721 200 µM 0.464271954906336 0.310596877152061 no 1066 0.321226457189729 1615 2981221 SGTC_1662 st014054 52 µM 0.463718674872615 0.310801297787368 no 1067 0.321424657838283 1503 2838777 SGTC_744 1594-0068 283 µM 0.463182305442575 0.310999526218452 no 1068 0.321616849178184 1537 668392 SGTC_222 nsc-310342 10.666 µM 0.4629095451272 0.311100352501069 no 1069 0.321714602691863 1608 432556 SGTC_1521 st012942 49.4 µM 0.461679811617604 0.311555101411157 no 1070 0.322155475315508 1716 24207259 SGTC_1444 4112-3581 28 µM 0.458927978691963 0.31257375570124 no 1071 0.323142943094356 1549 2877249 SGTC_1636 st007707 68.9 µM 0.458570566861516 0.312706165264228 no 1072 0.323271288449612 1634 403051 SGTC_751 0833-0568 350 µM 0.457878138244432 0.312962756519298 no 1073 0.323519997023516 1592 6954252 SGTC_677 0929-0063 136 µM 0.455885626128337 0.313701621196655 no 1074 0.324236113120374 1509 1539583 SGTC_454 lyso-paf C-16 6.67 µM 0.45581152193632 0.31372911500497 no 1075 0.324262759002146 1445 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1965 Pectolinarigenin 58.4 µM 0.455350314554184 0.313900253370672 no 1076 0.324428617046476 1516 5320438 An anti-inflammatory. SGTC_1588 farnesol 29.9 µM 0.454333372088501 0.314277747555548 no 1077 0.324794449957999 1517 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1466 k213-0079 57.5 µM 0.453806391528753 0.31447344187488 no 1078 0.324984091446703 1542 3657981 SGTC_1623 st003709 20.3 µM 0.453040459405604 0.314757963854504 no 1079 0.325259803931152 1512 16192618 SGTC_2321 7390090 138.78 µM 0.451768575472415 0.315230675479133 no 1080 0.325717855137322 1476 649046 SGTC_1927 st060202 13.8 µM 0.451483794025779 0.315336559577882 no 1081 0.325820451285603 1630 688887 SGTC_2847 9005661 71.43 µM 0.450567804396273 0.315677234927701 no 1082 0.326150537655204 1524 2991449 SGTC_1552 6-methylflavone 10.6 µM 0.450243498012508 0.315797888701726 no 1083 0.326267437499421 1591 689013 SGTC_895 0964-0006 13.7 µM 0.44959788517417 0.316038138595646 no 1084 0.326500206638096 1542 6738897 SGTC_1432 4049-0298 68.4 µM 0.448512643977705 0.316442161087668 no 1085 0.326891631531729 1645 741646 SGTC_2182 6325192 200 µM 0.448260681646536 0.316535995057036 no 1086 0.326982536600514 1532 736248 SGTC_738 1315-0003 72.4 µM 0.44712236661521 0.316960065145771 no 1087 0.327393355292541 1630 6251474 SGTC_983 1491-0821 12.2 µM 0.444482863098544 0.31794431581403 no 1088 0.328346757983331 1639 46495113 SGTC_296 1222-0039 74.9 µM 0.4427771070029 0.318581064564687 no 1089 0.328963481822257 1512 5984176 SGTC_1130 3454-2858 15.9 µM 0.44277669723181 0.318581217594318 no 1090 0.32896363003289 1517 715628 YIL048W NEO1 SGTC_1790 st045711 43.5 µM 0.442502028451447 0.318683800025536 no 1091 0.329062981386961 1683 585119 SGTC_2087 5276107 200 µM 0.441579158154436 0.319028572469063 no 1092 0.329396884275067 1541 144405 SGTC_3230 9131665 49.47 µM 0.44090093427547 0.319282048033701 no 1093 0.32964235863475 1563 15943720 SGTC_1644 st010134 20.9 µM 0.440474598771597 0.319441427517054 no 1094 0.329796702840566 1592 3818134 SGTC_1872 amphotericin b 148 nM 0.438440716428 0.320202224410254 no 1095 0.330533418155036 1636 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1462 k081-0014 26.5 µM 0.4344594416374 0.321693653311799 no 1096 0.331977420498801 1452 3270634 SGTC_932 2857-0803 154 µM 0.434018977613348 0.32185883317454 no 1097 0.332137330055692 1682 674898 SGTC_806 3966-4455 5.86 µM 0.433916479187946 0.321897276497392 no 1098 0.332174546283901 1514 714982 SGTC_993 3909-8757 62.7 µM 0.430960416135411 0.323006804001804 no 1099 0.333248576358907 1595 4288324 YLR208W SEC13 SGTC_362 0310-0100 9.03 µM 0.430628635650575 0.323131432955618 no 1100 0.333369208174606 1580 790235 SGTC_625 k213-0058 121 µM 0.429453835109041 0.323572890808855 no 1101 0.333796491512579 1658 3655420 SGTC_2641 levomentholum 100 µM 0.428192434709795 0.324047167085277 no 1102 0.334255511880169 1576 16666 SGTC_104 0074-0074 590.992 µM 0.426133264274251 0.324822012109111 no 1103 0.335005371302336 1591 3943124 SGTC_1413 3910-0535 34.4 µM 0.420934285365632 0.326781704711213 no 1104 0.336901534274585 1682 2876951 SGTC_112 phenothiazine 287.218 µM 0.419789173064521 0.327213986356766 no 1105 0.337319737467084 1739 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1757 st041620 31.8375 µM 0.41589059486883 0.328687441212401 no 1106 0.338745031000992 1579 5289815 SGTC_1026 k007-1105 30.6 µM 0.414558426713434 0.329191542414788 no 1107 0.33923259365067 1599 7066794 SGTC_2994 9053520 71.4286 µM 0.414316658438568 0.329283062460792 no 1108 0.33932110775869 1713 4647384 SGTC_1491 4138-0063 26.5 µM 0.413176399804582 0.329714838900018 no 1109 0.339738688832535 1670 23883227 SGTC_1441 4106-0040 13 µM 0.413072764872458 0.329754093122288 no 1110 0.339776651375488 1599 2904180 SGTC_439 amiodarone 34.4 µM 0.412878725250552 0.329827595336853 no 1111 0.33984773445716 1680 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2247 cerulenin 830 nM 0.411730590265883 0.330262643305649 no 1112 0.340268450451484 1696 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1943 st076331 65.2 µM 0.411388277764133 0.330392395813598 no 1113 0.340393923997361 1651 24208415 SGTC_412 gemfibrozil 100 µM 0.410910053246636 0.330573699500235 no 1114 0.340569245240257 1636 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2215 7188065 200 µM 0.410738190000878 0.330638865724728 no 1115 0.34063226021006 1674 940217 SGTC_421 streptovitacin 30 mM 0.410184317684781 0.330848915117415 no 1116 0.340835371980239 1608 91467 include heat shock SGTC_1754 st042065 16.137 µM 0.408225648163426 0.331592143772734 no 1117 0.341554009927703 1568 1126236 YIL048W NEO1 SGTC_2522 biochanin a 4.94 µM 0.406628007919569 0.332198869275584 no 1118 0.342140611619125 1665 5280373 A possible chelator. SGTC_467 ro 31-8220 72.8 µM 0.405719953440225 0.332543911520119 no 1119 0.342474189766509 1700 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_150 3970-0969 77.2 µM 0.405309345609783 0.33269998076624 no 1120 0.342625068884118 1652 6615640 SGTC_2734 clemastine 41.6 µM 0.405079788601618 0.332787246464439 no 1121 0.342709431262343 1647 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2976 9009005 19.48 µM 0.404661937892444 0.332946114937103 no 1122 0.342863011855547 1764 2993148 SGTC_2875 9039966 71.43 µM 0.40015082830369 0.33466316103004 no 1123 0.34452271450486 1726 6463691 SGTC_2735 sertaconazole 140 nM 0.400132822657903 0.334670021411426 no 1124 0.344529345070329 1698 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_435 c-PAF 6.7 µM 0.395073219156091 0.33659997446693 no 1125 0.346394426303034 1649 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_785 1270-0111 65.3 µM 0.392708918622648 0.33750330316749 no 1126 0.347267241357284 1611 6741994 SGTC_374 0880-0231 82.3 µM 0.391968087562584 0.337786545706993 no 1127 0.347540896663283 1684 6833587 SGTC_2989 9073649 71.4286 µM 0.391501001530032 0.337965174331196 no 1128 0.347713474255792 1745 21367202 SGTC_2879 9041815 71.43 µM 0.391447872941598 0.337985494713355 no 1129 0.347733106052272 1619 4942971 SGTC_2980 9014342 25.29 µM 0.388890865747702 0.338964044442259 no 1130 0.348678439723248 1645 2996599 SGTC_2074 5212007 75.395 µM 0.387121175585374 0.339641930449338 no 1131 0.349333250812463 1784 758611 SGTC_3229 9132204 49.47 µM 0.386884175816951 0.33973275349771 no 1132 0.349420978283874 1694 17682924 SGTC_1028 k015-0029 4.8 µM 0.386719420779564 0.339795896404511 no 1133 0.349481968496291 1604 4588309 SGTC_2514 salinomycin 42.74 µM 0.384166601375838 0.340774846310239 no 1134 0.350427485388745 1800 23682228 A polyether potassium ionophore. SGTC_224 benfluorex 43.875 µM 0.384063511887141 0.340814401444072 no 1135 0.350465687344473 1750 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2898 9056270 58.44 µM 0.382773769198247 0.341309419724582 no 1136 0.350943756066555 1662 19154699 SGTC_273 hydroxyurea 18.1 mM 0.380616271704633 0.34213810280109 no 1137 0.351744002736867 1678 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1009 4106-0057 9.87 µM 0.379188111573519 0.3426870701663 no 1138 0.35227408957026 1752 2928005 SGTC_1570 verbenone 133 µM 0.374919403014603 0.344329887427564 no 1139 0.353860204179729 1806 29025 A natural terpanoid with antifungal properties. SGTC_297 0986-0032 24 µM 0.374674193920066 0.344424346049194 no 1140 0.353951393376922 1655 2847425 SGTC_2161 5662504 8.5105 µM 0.373396599469204 0.344916653555897 no 1141 0.354426645012462 1644 2859334 SGTC_954 1189-0853 2.85 µM 0.373261832502279 0.344968599910123 no 1142 0.354476790133904 1654 2828194 SGTC_970 1315-0089 19.5 µM 0.371118265284983 0.345795236973239 no 1143 0.355274723609313 1586 6811083 YLR033W RSC58 SGTC_3297 9117502 71.43 µM 0.370735030070877 0.345943103966686 no 1144 0.355417448239286 1684 7453720 SGTC_2069 5228469 200 µM 0.36978921843726 0.346308135253205 no 1145 0.355769774578001 1635 2835210 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.369523351375022 0.346410771049761 no 1146 0.355868835496335 1821 5024745 SGTC_2490 carminic acid 95.39 µM 0.365485512364226 0.347970928126272 no 1147 0.357374509703441 1684 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2458 5808907 16.39 µM 0.361937560368414 0.349343929144775 no 1148 0.358699345474339 1789 2731747 SGTC_731 3966-0296 387 µM 0.361937419088 0.349343983857466 no 1149 0.358699398263652 1682 660956 SGTC_2443 5493264 126.67 µM 0.361080110778285 0.349676045337073 no 1150 0.359019780494743 1783 5340055 SGTC_1866 st057638 64 µM 0.356483113756056 0.351458558266722 no 1151 0.360739397932251 1692 688802 SGTC_2752 diclazuril 33.15 µM 0.355409298625358 0.351875409285628 no 1152 0.361141491856071 1788 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_729 4092-0585 94.1 µM 0.355197314904885 0.351957721640199 no 1153 0.361220888073427 1646 2169061 SGTC_63 0099-0242 26.702 µM 0.35503007464409 0.352022665200701 no 1154 0.361283530329252 1782 3898502 YLR359W ADE13 SGTC_2597 laccaic acid a 100 µM 0.354903165200149 0.352071950180909 no 1155 0.361331068577242 1697 5491415 A textile dye. SGTC_816 0325-0417 81.3 µM 0.352421491970973 0.353036200557794 no 1156 0.362261093162716 1672 68101 SGTC_3079 9117512 49.47 µM 0.351754274669751 0.353295608195111 no 1157 0.362511276573885 1756 7185044 SGTC_2846 9008642 19.48 µM 0.351141407561507 0.353533945077684 no 1158 0.362741132288391 1675 2992898 SGTC_1712 st032288 53.4 µM 0.350312727437481 0.353856300451224 no 1159 0.363052007296065 1689 2883011 SGTC_2446 5162541 200 µM 0.34849842513848 0.354562427052866 no 1160 0.363732948171758 1664 1549321 SGTC_1642 st009582 77.7 µM 0.347049653880613 0.355126648221414 no 1161 0.364277007916888 1829 6739311 SGTC_611 3453-1652 23.7 µM 0.346505228918153 0.355338755688073 no 1162 0.364481527612496 1794 1560575 SGTC_284 0988-0104 32.6 µM 0.346450586948737 0.355360046625314 no 1163 0.364502056648089 1776 4666532 SGTC_3179 9107801 49.47 µM 0.34444183615293 0.356143057970825 no 1164 0.365257015381042 1686 4818259 SGTC_114 0364-0001 490.298 µM 0.34373558172258 0.356418500453583 no 1165 0.365522574765027 1652 4003655 SGTC_1684 st024538 14.6195 µM 0.343663786877148 0.356446504971419 no 1166 0.365549574023805 1684 6732859 SGTC_1796 st049173 110.4 µM 0.343403796920439 0.356547923928166 no 1167 0.36564735174324 1802 94134 SGTC_2455 5377712 9.75 µM 0.342586418958906 0.356866839294969 no 1168 0.365954810277217 1629 2243908 SGTC_940 3232-1287 54.8 µM 0.342335762192191 0.356964657798735 no 1169 0.366049112636215 1815 1585493 YIL048W NEO1 SGTC_562 3772-2733 112 µM 0.341365128207157 0.357343535217688 no 1170 0.366414361894346 1810 2876874 YIL048W NEO1 SGTC_474 dl-dihydrosphingosine 5 µM 0.341043599918704 0.357469071655205 no 1171 0.366535379590334 1775 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3210 9128157 49.47 µM 0.339323393202729 0.358140965168304 no 1172 0.367183060854072 1633 17590849 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.339281251788334 0.358157430658209 no 1173 0.367198932423236 1752 2724278 An inhibitor of dopamine biosynthesis. SGTC_4 0960-0234 25.671 µM 0.339254708282868 0.358167801869859 no 1174 0.367208929524607 1700 6821112 SGTC_1989 st071868 50.2 µM 0.338642358215739 0.358407091403118 no 1175 0.367439584394363 1847 16414057 SGTC_2184 6075246 200 µM 0.338625920287266 0.358413515659488 no 1176 0.367445776754542 1762 2267320 SGTC_2347 9049783 174.81 µM 0.336369092099747 0.359295906937304 no 1177 0.368296276952893 1779 6467988 YPL169C MEX67 SGTC_3157 9099274 49.47 µM 0.333812513434404 0.360296403985473 no 1178 0.369260520096778 1865 17217662 SGTC_279 1273-0055 2.93 µM 0.332453199175648 0.360828751316341 no 1179 0.369773536735315 1856 2847562 SGTC_17 0960-0276 49.807 µM 0.332019541424839 0.360998641217119 no 1180 0.369937251649549 1744 6821114 SGTC_2864 9034755 47.6 µM 0.330363004103821 0.361647859038085 no 1181 0.370562846080308 1845 4930451 SGTC_1554 st069299 38.7 µM 0.330047540257129 0.361771538512071 no 1182 0.370682020458933 1792 24207999 SGTC_2563 tomatine 8.54 µM 0.327783696256719 0.362659514918793 no 1183 0.371537607701791 1986 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1967 st070177 51.4 µM 0.327104282432221 0.362926154496735 no 1184 0.371794506459951 1795 5729214 SGTC_1950 st077106 7.18 µM 0.327092044494709 0.362930957950335 no 1185 0.371799134371151 1692 13831864 SGTC_1349 flufenamic acid 69 µM 0.326997945864981 0.362967892868231 no 1186 0.371834719425806 1723 3371 A non-steroidal anti-inflammatory. SGTC_1529 apigenin 74 µM 0.326512048966739 0.363158633904512 no 1187 0.37201848731724 1852 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2689 tacrolimus 100 µM 0.326062383633266 0.363335182318096 no 1188 0.372188578283263 1727 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2108 5365811 200 µM 0.323936643907825 0.36417018658952 no 1189 0.372993000344557 1801 780283 SGTC_315 k915-0449 187 µM 0.322265903493062 0.364826917263967 no 1190 0.373625630712941 1794 20970215 YNL149C PGA2 SGTC_947 3447-0010 211 µM 0.319383140604812 0.365960998938329 no 1191 0.374717996880808 1738 748350 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.319367889022976 0.36596700205088 no 1192 0.374723778850095 1719 279621 SGTC_262 fenpropimorph 62.5 µM 0.317347847705326 0.366762391692796 no 1193 0.375489837468616 1713 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_93 0109-0045 59.227 µM 0.317203374216243 0.366819299986627 no 1194 0.375544644888467 1851 88733 SGTC_807 1315-0151 48 µM 0.31687824684493 0.366947378782237 no 1195 0.37566799429631 1899 4011080 SGTC_2935 9038016 29.96 µM 0.315141808141237 0.36763167187501 no 1196 0.376326993125441 1879 6463195 SGTC_3303 9125618 40.5795 µM 0.314094390751303 0.368044639953194 no 1197 0.376724674825222 1834 22695467 SGTC_499 genistein 192 µM 0.312918637212923 0.368508389187588 no 1198 0.377171238847943 1820 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.312656555053356 0.368611787670304 no 1199 0.377270802928722 1717 229346 A bile salt which induces apoptosis. SGTC_614 0462-0418 107 µM 0.31256896951485 0.368646344649484 no 1200 0.377304078182658 1761 5188303 SGTC_2729 fluphenazine 10.66 µM 0.309604240388759 0.369816706946927 no 1201 0.378430965639517 1717 3372 An atypical antipsychotic. SGTC_1076 itraconazole 331 nM 0.308700859636116 0.370173567716139 no 1202 0.378774544925827 1783 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_501 nsc-95397 161 µM 0.308282102867196 0.370339026339287 no 1203 0.378933841579584 1856 262093 SGTC_159 3970-0959 50 µM 0.307843890726033 0.37051219783407 no 1204 0.379100561151058 1841 6615653 SGTC_1341 1486-1360 280 µM 0.306250500530399 0.371142090429339 no 1205 0.379706962224569 1741 3976547 SGTC_1634 st006576 41 µM 0.305663963884241 0.37137404478822 no 1206 0.379930256760467 1913 3915356 SGTC_3024 9090631 49.47 µM 0.304276339487103 0.371922986711268 no 1207 0.380458684725122 1918 25236383 SGTC_413 propylparaben 100 µM 0.303623787088069 0.372181225476283 no 1208 0.380707263568206 1724 7175 A pharmaceutical preservative. SGTC_529 4076-0302 30.3 µM 0.30266392396071 0.37256118275404 no 1209 0.381072996741201 1746 5816522 SGTC_1780 st038448 24.544 µM 0.301594360213021 0.372984710627219 no 1210 0.381480653908975 1859 728868 YDL195W SEC31 SGTC_328 k915-0120 63.5 µM 0.300997989392004 0.373220929385797 no 1211 0.381708013852817 1895 6624543 SGTC_688 0527-0193 473 µM 0.297901471449382 0.374448205148487 no 1212 0.382889182430426 1819 4007154 SGTC_2561 acetosyringone 100 µM 0.297421778893362 0.374638440982856 no 1213 0.383072259210282 1771 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3235 9132602 49.47 µM 0.297184541972727 0.374732535365031 no 1214 0.383162811383749 1809 4912240 SGTC_105 0111-0055 734.78 µM 0.296649650299164 0.374944714783989 no 1215 0.383367000340151 1802 5179370 SGTC_2143 5623677 140.463 µM 0.296579536308765 0.374972530224495 no 1216 0.383393767980546 1866 5375313 SGTC_1273 0849-0096 14.1 µM 0.296368327904854 0.375056324204504 no 1217 0.383474405045856 1759 5286025 SGTC_2010 4012422 159 µM 0.2957771328885 0.375290903903734 no 1218 0.383700143684202 1825 952393 SGTC_713 1488-1073 324 µM 0.294888593304056 0.375643553401259 no 1219 0.38403949295874 1908 3312542 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.294426044833059 0.375827173860619 no 1220 0.384216183764414 1775 442882 SGTC_576 1073-0113 22.7 µM 0.294087879695407 0.375961434969155 no 1221 0.384345376095365 1906 5439563 SGTC_2917 7979103 53.79 µM 0.293566222938772 0.376168576875595 no 1222 0.384544694606897 1886 2980565 SGTC_2558 carylophyllene oxide 100 µM 0.293290689169578 0.376278001517088 no 1223 0.384649984931392 1811 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.293289987774051 0.376278280079865 no 1224 0.384650252968066 1883 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2362 9071156 126 µM 0.291209499515303 0.37710483952449 no 1225 0.385445548855172 1853 653133 SGTC_1666 st014829 29 µM 0.290493069014707 0.377389601589746 no 1226 0.385719526210047 1780 3858230 SGTC_660 4031-1742 102 µM 0.289803217212944 0.377663862343019 no 1227 0.385983393231764 1784 6738706 SGTC_2139 5578692 56.4705 µM 0.287247002728263 0.378680659906633 no 1228 0.386961599517428 1916 650991 YMR113W FOL3 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.286378101081166 0.379026478771052 no 1229 0.387294272727637 1675 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3288 9119690 36.221 µM 0.286133059864745 0.379124021569357 no 1230 0.387388105742275 1733 17595618 YKL019W RAM2 SGTC_1434 4073-0095 163 µM 0.286100740587083 0.37913688737882 no 1231 0.38740048217293 1882 24133745 SGTC_1854 st056233 32.9 µM 0.283796085960495 0.380054679457373 no 1232 0.388283327106424 1943 5393174 SGTC_3325 9138760 55.175 µM 0.283349479685593 0.38023261164679 no 1233 0.388454475689699 1757 43844959 SGTC_1288 0973-0013 65.5 µM 0.28334947123198 0.38023261501503 no 1234 0.3884544789295 1825 4315430 SGTC_3337 9144342 33.5465 µM 0.283148389546536 0.380312736150079 no 1235 0.388531544583485 1883 17682949 SGTC_2326 6164455 177.58 µM 0.282130978647926 0.38071820287892 no 1236 0.38892154007395 1786 2888790 SGTC_1805 st050013 60.3 µM 0.277748820163977 0.382466108336763 no 1237 0.390602590687689 1900 4037144 SGTC_209 4077-0173 175.592 µM 0.277566132136836 0.382539029154029 no 1238 0.390672716753105 1846 15993494 SGTC_2765 myclobutanil 7.74 µM 0.277244391951323 0.382667463443927 no 1239 0.390796227598066 1815 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_466 geldanamycin 89.2 µM 0.276531022017831 0.382952276991697 no 1240 0.391070118038157 1937 5288382 HSP90 inhibitor. SGTC_2859 9028643 45.46 µM 0.272769661332995 0.38445504675458 no 1241 0.392515141116893 1911 17151580 SGTC_330 1488-0319 80.1 µM 0.27276079363886 0.384458591711203 no 1242 0.392518549628893 1849 6846614 SGTC_1151 3909-8316 15.3 µM 0.272439834546486 0.384586905080896 no 1243 0.392641923540282 1826 800431 SGTC_1825 st052143 62.6 µM 0.272115212778185 0.384716695581325 no 1244 0.392766716326627 1910 674173 SGTC_2716 st080858 38.6235 µM 0.2717731990687 0.384853453718017 no 1245 0.392898206938858 1916 5296050 SGTC_968 1309-0633 340 µM 0.271528534688993 0.38495129439095 no 1246 0.392992278121741 1937 3761976 SGTC_2777 climbazole 1.536 µM 0.270891524580753 0.38520606749164 no 1247 0.393237231900593 1867 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3164 9100705 49.47 µM 0.270331207930932 0.385430207905108 no 1248 0.393452729176558 1915 17174235 SGTC_810 3825-7150 143 µM 0.268527187204792 0.386152120104737 no 1249 0.394146775345628 1992 22330411 YGL099W LSG1 SGTC_193 1273-0060 1.558 µM 0.264429520633191 0.387793338595761 no 1250 0.395724483317512 1929 2847393 YHR072W ERG7 SGTC_3345 9148410 3.559 µM 0.264407920294216 0.387801995416858 no 1251 0.395732804562193 1929 4903596 SGTC_2285 7945142 200 µM 0.261331743299738 0.389035409990835 no 1252 0.396918344620266 1809 2970608 SGTC_464 bw-b 70c 158 µM 0.260331673940204 0.389436636422039 no 1253 0.397303971193349 1934 5353454 SGTC_3331 9141060 1.957 µM 0.258480330859224 0.390179703515932 no 1254 0.398018113492448 1794 4906567 YPR165W RHO1 SGTC_482 fipronil 114 µM 0.258411257481273 0.390207435040442 no 1255 0.398044764680794 1890 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2044 5102272 200 µM 0.257064119380423 0.390748394506864 no 1256 0.398564637775993 1856 592666 SGTC_1664 st014217 9.02 µM 0.256895436392889 0.390816146105722 no 1257 0.398629746809462 1961 3982782 SGTC_12 0849-0099 9.267 µM 0.256231234128896 0.39108295544965 no 1258 0.398886146058112 1957 6071388 SGTC_198 3454-2873 16.191 µM 0.25579780646856 0.391257090532417 no 1259 0.399053483879377 1870 710957 SGTC_2828 7998861 71.43 µM 0.255512124372854 0.391371878874402 no 1260 0.39916379021583 1987 2988188 SGTC_3256 9138902 49.47 µM 0.254612617446922 0.391733366522913 no 1261 0.399511156494675 1925 17228773 SGTC_1628 st004252 77.7 µM 0.254598857261281 0.391738897098402 no 1262 0.399516470940552 1954 692968 SGTC_646 4092-0839 27.3 µM 0.254196303329246 0.391900703642494 no 1263 0.399671953174905 1942 877796 SGTC_791 1348-1292 225 µM 0.253895645966395 0.392021565062424 no 1264 0.399788089308863 1942 5437054 SGTC_1635 st007035 42.4 µM 0.253607649720157 0.392137346603806 no 1265 0.399899343095798 1854 3716403 SGTC_2834 9001755 58.44 µM 0.253256571806579 0.392278501436547 no 1266 0.40003497650415 1830 2989575 SGTC_1803 st050068 52.4 µM 0.253254959303569 0.392279149794276 no 1267 0.400035599497062 1893 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2814 7977482 42.97 µM 0.25255789328648 0.392559455169573 no 1268 0.400304935785022 1951 6456762 SGTC_1043 0916-0009 19.3 µM 0.252220909402413 0.392694983700022 no 1269 0.400435158524496 2023 3101130 SGTC_2881 9058953 51.95 µM 0.250315973591463 0.393461356998007 no 1270 0.401171502230997 1891 17122249 SGTC_2601 securinine 100 µM 0.249649116933439 0.393729737335484 no 1271 0.401429355559802 1824 442872 A GABA receptor antagonist. SGTC_1753 st043925 64 µM 0.248983450186181 0.393997689140295 no 1272 0.401686791602317 1988 670181 SGTC_704 1310-0270 142 µM 0.248551587728937 0.394171554213754 no 1273 0.401853830377435 1810 5718033 SGTC_2996 9066192 71.4286 µM 0.247967117651992 0.394406891723905 no 1274 0.402079924342088 1778 6472854 SGTC_2217 6934799 96.0675 µM 0.247689220050837 0.394518801021248 no 1275 0.402187436589211 1956 675606 SGTC_1681 tripelennamine 100 µM 0.246994109403717 0.394798760016534 no 1276 0.402456391442996 1883 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1878 temozolomide 1 mM 0.246533639724696 0.394984246213911 no 1277 0.402634583557552 2022 5394 DNA alkylating agent. SGTC_1192 1488-0095 21.4 µM 0.245913384296203 0.395234134856171 no 1278 0.4028746413791 1886 915875 SGTC_2380 9035439 200 µM 0.245661386809856 0.395335671973749 no 1279 0.402972182579555 1939 6462575 SGTC_1973 st070275 50.2 µM 0.245449559346504 0.395421028918116 no 1280 0.403054179755835 1985 17118334 SGTC_33 0986-0033 35.816 µM 0.245228889053371 0.395509954461107 no 1281 0.403139604473992 1944 2848082 SGTC_1422 4031-0024 15.5 µM 0.245032339390422 0.395589164472454 no 1282 0.403215695633849 1971 782427 SGTC_2239 6685329 187.64 µM 0.244970632023996 0.395614033586969 no 1283 0.403239585441681 1826 805680 SGTC_2902 5787006 60.46 µM 0.24430679060297 0.395881599791703 no 1284 0.403496612328448 1828 591003 SGTC_3293 9120939 62.045 µM 0.244050772292895 0.395984802986802 no 1285 0.403595748937783 1925 934087 SGTC_2678 equilin 100 µM 0.243526370138945 0.396196216786283 no 1286 0.40379882972808 1992 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_425 3825-7017 13.1 µM 0.242503798614519 0.396608556347268 no 1287 0.404194906910035 1918 3397440 SGTC_2418 pentamidine 31.67 µM 0.242088969917496 0.39677586398729 no 1288 0.404355612386004 1995 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3009 9080819 71.4286 µM 0.241497883511878 0.397014292256193 no 1289 0.404584628331384 1851 17027216 SGTC_750 4073-0104 132 µM 0.240341755962704 0.397480754056412 no 1290 0.405032663447873 1951 22330957 SGTC_988 1497-1057 103 µM 0.240048712006512 0.397599011574458 no 1291 0.405146246829502 2028 3533044 SGTC_383 2324-0395 7.37 µM 0.239037031580185 0.398007346197923 no 1292 0.405538433939997 1934 3146421 SGTC_1815 st051655 58.2 µM 0.238799275507785 0.398103325576022 no 1293 0.405630616021209 2010 5984156 SGTC_3341 9147222 25.867 µM 0.2387817130102 0.398110415597915 no 1294 0.405637425508478 1890 1939759 SGTC_959 1222-0044 107 µM 0.238561042984774 0.398199503476409 no 1295 0.40572298808006 2038 6083612 SGTC_1456 k015-0012 13 µM 0.237901423688229 0.398465833540664 no 1296 0.405978775634531 2042 2989616 SGTC_588 3970-1144 52.9 µM 0.237813401484673 0.398501377255755 no 1297 0.406012911973914 1974 1888707 SGTC_3094 9117742 49.47 µM 0.235693809790015 0.399357530395802 no 1298 0.40683513683186 1972 17149698 SGTC_1052 3253-3998 198 µM 0.235516393733982 0.399429214950475 no 1299 0.406903978152604 1942 5450317 SGTC_832 4083-0019 164 µM 0.235083034641655 0.399604326959901 no 1300 0.407072143074949 1969 1990758 SGTC_3283 9109332 35.8195 µM 0.233998198174435 0.400042776838868 no 1301 0.407493188743111 1896 17027281 SGTC_1209 2323-2347 50.3 µM 0.233362610083384 0.400299716099922 no 1302 0.407739922261964 2039 5412760 SGTC_3270 9137563 49.47 µM 0.233141617502003 0.400389063433026 no 1303 0.407825719543573 1962 17015724 SGTC_2708 st078559 56 µM 0.232982512753291 0.400453392734188 no 1304 0.407887492476188 1975 17250902 SGTC_536 3852-0578 10.6 µM 0.23278049436618 0.400535076787273 no 1305 0.407965930066946 2012 2869208 SGTC_3232 9132874 49.47 µM 0.230799180900327 0.401336430490947 no 1306 0.408735408801855 1852 3784940 SGTC_3224 9130643 49.47 µM 0.230799143937657 0.401336445444596 no 1307 0.408735423160265 1934 17644395 SGTC_2076 5212012 200 µM 0.228496151410038 0.402268425701083 no 1308 0.409630273862849 1942 604802 SGTC_2899 9053889 58.44 µM 0.227410860924122 0.402707816548666 no 1309 0.410052137859333 2044 6470052 SGTC_2575 plumbagin 510 nM 0.227080489367798 0.402841595249258 no 1310 0.410180577505373 1817 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2192 5915882 198.485 µM 0.226156600611169 0.403215769628084 no 1311 0.410539811913099 1922 2876149 SGTC_623 k072-0108 16.9 µM 0.225680936692727 0.403408447807371 no 1312 0.410724792958771 1920 5382803 SGTC_2780 5215298 71.43 µM 0.22541582958568 0.403515845477838 no 1313 0.410827899140656 2067 2834131 SGTC_1819 st053448 58.6 µM 0.22393251326278 0.404116886514537 no 1314 0.411404908078631 1930 2857616 SGTC_3133 9127736 49.47 µM 0.222224356711907 0.404809313430989 no 1315 0.412069617101139 2075 27243420 SGTC_1227 3909-8010 46.6 µM 0.221929190415869 0.404928993796588 no 1316 0.412184503215705 1924 15982272 SGTC_179 1273-0063 6.77 µM 0.220717415044887 0.405420422512671 no 1317 0.412656235305666 1862 3108139 SGTC_496 calpeptin 138 µM 0.219843684570673 0.405774851593613 no 1318 0.412996448213931 1894 73364 A calpain inhibitor. SGTC_373 0844-0104 25.9 µM 0.217825040591107 0.40659401022516 no 1319 0.413782716711254 2035 5375804 SGTC_2086 5274770 176.623 µM 0.216269421568213 0.407225554135141 no 1320 0.414388871542969 1912 689278 SGTC_3066 9117245 49.47 µM 0.215382497308277 0.407585732150725 no 1321 0.414734557458012 1974 17176980 SGTC_1771 st048882 4.1505 µM 0.215242885893728 0.407642435168248 no 1322 0.41478897816048 1832 4580403 SGTC_2015 5119600 184 µM 0.214923286498408 0.407772247382689 no 1323 0.41491356455631 2008 2828786 SGTC_2650 prasterone 100 µM 0.212355625990546 0.408815524601789 no 1324 0.415914800791918 1979 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_316 k060-0003 58.6 µM 0.211765289092118 0.409055478595223 no 1325 0.416145074819111 2008 6152314 SGTC_2507 purpurin 79.67 µM 0.210893169322157 0.409410031103811 no 1326 0.416485317176766 1817 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_902 1120-0002 2.07 µM 0.210504133217365 0.40956821418041 no 1327 0.416637113046142 1899 3280475 SGTC_3135 9127742 49.47 µM 0.210146608786023 0.409713597512625 no 1328 0.416776624510559 1887 3643468 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.209817402255895 0.409847476664684 no 1329 0.416905095169878 2026 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2568 diosmetin 100 µM 0.209329110130032 0.410046070862854 no 1330 0.417095664264029 2076 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1916 st067606 49.2 µM 0.20604926134483 0.411380619879888 no 1331 0.418376215909648 2004 19590279 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.205678072544882 0.411531719092491 no 1332 0.418521193961513 1955 364106 SGTC_1241 0364-0022 50.8 µM 0.205052260876638 0.411786496915667 no 1333 0.418765647069147 1969 4563895 SGTC_2352 9027995 87.8 µM 0.204108775438491 0.412170675027225 no 1334 0.419134248441315 1972 2997347 SGTC_3272 9137413 49.47 µM 0.204057539737377 0.412191540120503 no 1335 0.419154267266208 2029 17614870 SGTC_2382 9035899 200 µM 0.203735518376313 0.412322684939636 no 1336 0.419280092315879 1911 6462679 SGTC_170 4197-0004 226 µM 0.203376373936241 0.412468959867336 no 1337 0.419420432392759 1970 218692 SGTC_1015 4130-4525 82 µM 0.202907767740531 0.412659835443765 no 1338 0.419603561398756 1871 1363237 SGTC_2445 5742597 35.57 µM 0.202256232857149 0.41292525698021 no 1339 0.41985820696824 1917 1774255 SGTC_3161 9100388 49.47 µM 0.202096367871449 0.412990388682677 no 1340 0.419920693650936 1988 25236368 SGTC_511 blebbistatin 171 µM 0.200598455761361 0.413600779569259 no 1341 0.420506282826325 2038 3476986 A myosin inhibitor. SGTC_1323 1348-1351 11.2 µM 0.200115892434199 0.413797466000072 no 1342 0.420694972196526 1909 6989654 SGTC_3247 9135149 49.47 µM 0.197521546093611 0.414855256766502 no 1343 0.421709711107551 2010 8934436 YOR116C RPO31 SGTC_3248 9135562 49.47 µM 0.197495769641091 0.414865769690337 no 1344 0.421719795793332 1933 17650701 SGTC_2309 7664088 163.95 µM 0.197100642952986 0.415026929700616 no 1345 0.421874390146848 2101 704922 SGTC_1402 3909-7673 35.9 µM 0.197061464284168 0.415042910253024 no 1346 0.421889719560316 1992 5328014 SGTC_2297 7971671 152.32 µM 0.196738836685298 0.415174511880147 no 1347 0.422015958359059 2029 909016 SGTC_2223 6903751 107.57 µM 0.196558540121756 0.415248060017449 no 1348 0.422086508888484 2020 5598863 SGTC_937 3122-0005 46.7 µM 0.195037938842358 0.41586847477886 no 1349 0.422681623500972 2076 759535 SGTC_3013 9080133 71.4286 µM 0.19502180331772 0.415875059300418 no 1350 0.422687939377088 2013 17050193 SGTC_1677 st019204 53.9 µM 0.194310305417694 0.416165428025365 no 1351 0.422966458431825 1881 3945625 SGTC_1073 triclabendazole 3.09 µM 0.193899164724144 0.416333239132715 no 1352 0.423127418870443 1963 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1862 st057513 3.81 µM 0.193333005438961 0.416564347555157 no 1353 0.423349089653265 1958 5393163 SGTC_3071 9117417 49.47 µM 0.192547310595789 0.416885119019673 no 1354 0.423656756326305 2082 45595590 YGL055W OLE1 SGTC_2922 7999257 32.47 µM 0.191559270699572 0.417288579358573 no 1355 0.424043724430725 2032 2988377 SGTC_3073 9114972 49.47 µM 0.191379996200083 0.417361794405242 no 1356 0.424113945563551 2097 41905075 SGTC_372 0155-0182 15.9 µM 0.19118375050328 0.417441943711462 no 1357 0.424190817011308 1992 771486 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.190592398606353 0.417683480280017 no 1358 0.424422473029392 2039 88881 An O-methylated flavonoid and antioxidant. SGTC_3057 9095946 49.47 µM 0.189668732908628 0.418060811904861 no 1359 0.424784361771988 2034 24540043 SGTC_2470 5664817 21.68 µM 0.188566080669384 0.418511361033117 no 1360 0.425216459767698 2095 2859561 SGTC_1734 st037168 69.4 µM 0.188266558715896 0.418633765669015 no 1361 0.425333849427135 1890 708907 SGTC_1029 k015-0030 64.7 µM 0.187806043994206 0.418821978046456 no 1362 0.425514348827748 1986 2208316 SGTC_2732 terfenadine 20 µM 0.187739217945086 0.418849291399197 no 1363 0.425540542690772 2069 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1008 4106-0037 6 µM 0.187177493550094 0.419078896609759 no 1364 0.425760735257273 1980 2905394 SGTC_1739 st037196 92.5 µM 0.186872861867254 0.419203426539596 no 1365 0.425880158722059 2099 612214 SGTC_555 4296-0685 37 µM 0.183951713075664 0.42039796777081 no 1366 0.427025667889618 2040 2908540 YHR072W ERG7 SGTC_2118 5526350 200 µM 0.182945774794793 0.420809495032727 no 1367 0.427420282927871 2002 743594 SGTC_689 0833-0039 98 µM 0.180597001784127 0.421770709426594 no 1368 0.428341954708051 2076 5374726 SGTC_2029 5175081 200 µM 0.180209751261178 0.421929233175076 no 1369 0.428493951680316 2039 1380876 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.17925418053556 0.422320456900644 no 1370 0.428869061344341 2080 140250 A respiratory chain inhibitor. SGTC_2432 5630864 12.22 µM 0.17804853993905 0.4228141719736 no 1371 0.429342427675842 1974 5714970 SGTC_3037 9091026 49.47 µM 0.177972128272666 0.42284546697803 no 1372 0.429372432345142 2054 25236398 YIL048W NEO1 SGTC_2587 piperic acid 92.2 µM 0.175757763101667 0.423752588543411 no 1373 0.430242126584843 1963 5370536 SGTC_3103 9120822 49.47 µM 0.175289100319659 0.423944629695465 no 1374 0.430426237930736 2081 17141819 SGTC_2884 9058502 51.95 µM 0.17339828338671 0.424719601454553 no 1375 0.431169187163664 1999 6471554 SGTC_1346 1488-2224 62.4 µM 0.173344880047067 0.424741493631107 no 1376 0.431190174220323 2106 3722427 SGTC_2065 5221596 34.26 µM 0.172391071639049 0.425132537090931 no 1377 0.431565045451171 2031 788581 SGTC_1427 4048-4900 550 nM 0.171402299857667 0.42553799264458 no 1378 0.431953723257878 2117 24132586 SGTC_1889 st059080 5.18 µM 0.170866407336408 0.425757773557532 no 1379 0.432164405617085 2155 176925 Isolated from Daphnopsis sellowiana. SGTC_1737 st035557 69.7 µM 0.170713283826065 0.425820577003781 no 1380 0.432224608589879 2066 5716916 SGTC_3217 9129673 49.47 µM 0.170653767561408 0.425844988044881 no 1381 0.432248008792105 2017 17248312 SGTC_1897 st060201 15 µM 0.170098216453929 0.426072865182105 no 1382 0.432466448070207 1930 611878 SGTC_2908 7930301 100 µM 0.169996543954002 0.426114572099526 no 1383 0.432506427308363 2063 2223178 SGTC_1604 st002052 72.4 µM 0.16886947742251 0.426576959556199 no 1384 0.432949653925028 2017 6254834 YHR062C RPP1 SGTC_2473 5854593 8.94 µM 0.168719733878478 0.426638400572175 no 1385 0.433008547958183 1963 2872951 SGTC_2698 st077697 67.5 µM 0.168247132085978 0.426832324669365 no 1386 0.433194431671645 1951 3154499 SGTC_3334 9142812 21.919 µM 0.16819914222263 0.426852017482468 no 1387 0.433213307869641 2059 45283678 SGTC_1135 dihydrocapsaicin 536.708 nM 0.164172821033829 0.428504877490334 no 1388 0.434797548226641 1935 107982 A Capsaicinoid. SGTC_678 1218-2179 85.9 µM 0.163960975293753 0.428591878071113 no 1389 0.434880932594837 2122 6820081 YOR116C RPO31 SGTC_352 k048-0007 5.11 µM 0.163216193220552 0.428897771890998 no 1390 0.435174108412181 2107 6811911 SGTC_685 1278-0033 54.9 µM 0.162521972528025 0.429182937814437 no 1391 0.435447413357848 2093 3590572 SGTC_722 3534-0461 190 µM 0.161402461224732 0.429642878712772 no 1392 0.435888214156129 1980 658262 SGTC_694 1315-0438 43.2 µM 0.161380994405538 0.429651699092821 no 1393 0.435896667366304 2054 6793154 SGTC_2683 piperine 63.03 µM 0.160499363112623 0.430013977879779 no 1394 0.436243861642847 2030 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1298 1079-1278 263 µM 0.160158808399585 0.430153933975466 no 1395 0.436377988299348 2013 2840950 SGTC_2011 4012611 177 µM 0.160150451520404 0.430157368471396 no 1396 0.436381279728185 2001 2049887 SGTC_3197 9113331 49.47 µM 0.160021127610528 0.430210518464434 no 1397 0.43643221562529 2082 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1372 2752-0194 270 µM 0.159058366153816 0.430606237221909 no 1398 0.436811444773986 2079 823334 SGTC_2172 5754775 163.918 µM 0.158562391789812 0.430810122169877 no 1399 0.437006830429979 1996 2263357 SGTC_379 3970-0972 5.9 µM 0.158359795816344 0.430893410551984 no 1400 0.437086646129689 2027 2898042 YBL034C STU1 SGTC_2960 9079389 5.97 µM 0.15819501948676 0.430961153325412 no 1401 0.437151564106174 2117 16457355 SGTC_1743 st037606 46.3785 µM 0.157121310864187 0.431402625604598 no 1402 0.437574621269816 2027 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_977 1348-1378 135 µM 0.156585710046675 0.431622878424564 no 1403 0.437785682669187 2110 X977 SGTC_1316 1272-0050 65.9 µM 0.156542598291397 0.43164060801161 no 1404 0.437802672262588 2065 7340392 SGTC_2661 dactinomycin 12.96 µM 0.156413313530851 0.431693776828137 no 1405 0.437853621826903 2106 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1247 0448-0043 5.84 µM 0.155788240281117 0.431950857857896 no 1406 0.438099970170966 2009 3089013 YGL099W LSG1 SGTC_2715 st079500 56.4 µM 0.155313872313297 0.432145975842051 no 1407 0.438286939897963 2013 28246688 SGTC_122 0236-0016 402.397 µM 0.154914947149354 0.432310075355103 no 1408 0.438444184891981 2125 6808838 SGTC_2808 7946468 45.46 µM 0.154750433550921 0.432377752105483 no 1409 0.43850903432169 2046 2970879 SGTC_2311 7694451 200 µM 0.154334275261098 0.432548957996184 no 1410 0.438673086654984 2064 2163142 SGTC_299 1273-0059 1.44 µM 0.153274161083513 0.432985141965759 no 1411 0.439091038176398 2133 2848077 SGTC_564 3555-0129 330 µM 0.1531018191273 0.433056059792864 no 1412 0.439158990667862 2155 563260 SGTC_44 0929-0055 61.211 µM 0.151912010868405 0.433545718462254 no 1413 0.439628167470712 2038 1379590 SGTC_754 3474-0146 171 µM 0.150866927496672 0.433975900631299 no 1414 0.440040344928508 1931 24762078 SGTC_3253 9135987 49.47 µM 0.150481325235365 0.434134643839943 no 1415 0.440192441634423 2077 4182430 SGTC_1827 berberine 7.24 µM 0.149143233324849 0.434685586433008 no 1416 0.440720306051634 1910 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1748 st037455 53.6035 µM 0.148391946205131 0.434994975176435 no 1417 0.441016727851982 2042 580690 SGTC_1933 st074711 15.9 µM 0.147264515525779 0.435459338827518 no 1418 0.441461619786916 2154 17250958 SGTC_2399 5884133 200 µM 0.147023357477239 0.435558678048128 no 1419 0.441556792028284 2002 722445 SGTC_1646 st011709 75.6 µM 0.144783973044915 0.43648133165202 no 1420 0.442440718270375 2157 5757843 SGTC_645 0845-0943 5.41 µM 0.144639299702213 0.436540950769341 no 1421 0.442497833404595 2053 1885106 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.143827170621547 0.436875651578394 no 1422 0.442818473443787 2126 4620898 SGTC_2588 indole-3-carbinol 100 µM 0.142423821569537 0.43745411683521 no 1423 0.443372623645101 2154 3712 Induces cell cycle arrest. SGTC_1230 0170-0365 3.77 µM 0.1421237370043 0.437577830110539 no 1424 0.443491134536636 2149 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2068 5226020 147 µM 0.142113499832514 0.437582050608762 no 1425 0.443495177540735 2039 1810509 SGTC_1287 0971-0001 34.6 µM 0.14168051678246 0.437760563848066 no 1426 0.443666182517595 2069 4665869 SGTC_2564 betulinic acid 100 µM 0.141346556011957 0.437898260154389 no 1427 0.443798086196933 2198 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1781 st038725 66.3 µM 0.140938291004198 0.438066603264464 no 1428 0.443959346098766 1963 4270275 YIL048W NEO1 SGTC_567 1080-0542 68.4 µM 0.139325550437712 0.438731706523211 no 1429 0.444596450227116 2159 5950415 SGTC_696 1560-0013 611 µM 0.137832841327625 0.439347462392166 no 1430 0.445186264220466 2128 1650269 SGTC_1358 1509-0022 2.48 µM 0.137704770254739 0.439400299714225 no 1431 0.445236874601344 2067 3258434 SGTC_253 dyclonine 31.25 µM 0.137322103405561 0.439558180134856 no 1432 0.445388099973255 2098 3180 An oral anasthetic. SGTC_14 0354-0009 295 µM 0.1370269097774 0.439679977485077 no 1433 0.445504762402953 2101 1713507 SGTC_339 3091-4833 71.4 µM 0.136529695835278 0.439885141633089 no 1434 0.44570127522968 2088 3240077 SGTC_1075 aripiprazole 15.2 µM 0.136409810653562 0.439934611974067 no 1435 0.445748659197277 2063 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3142 9086498 49.47 µM 0.135521241959838 0.440301306959777 no 1436 0.446099885264113 2185 25236367 SGTC_1276 0871-0068 94.2 µM 0.13547720691884 0.440319480697474 no 1437 0.446117292172307 2135 3414906 SGTC_2365 9042475 200 µM 0.135378456135692 0.440360236670815 no 1438 0.446156328412563 2043 6464479 SGTC_2414 st077232 92.9 µM 0.134801392407703 0.440598412404584 no 1439 0.44638445245274 1913 729801 SGTC_1382 3002-2117 298 µM 0.134460368662461 0.44073917573845 no 1440 0.44651927383851 2165 1497314 SGTC_2863 9028737 58.44 µM 0.134098818518595 0.440888419869001 no 1441 0.446662216945711 2185 6460917 SGTC_2206 7254556 146.969 µM 0.13408666995578 0.440893434815008 no 1442 0.446667020143541 2154 4398905 SGTC_1694 st024011 44.9 µM 0.133338774647829 0.441202185407675 no 1443 0.446962731816985 2164 2787533 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.133132373181346 0.441287399589991 no 1444 0.447044346464083 2166 1377 SGTC_1928 4'-methoxychalcone 40.3 µM 0.133128552200406 0.441288977132358 no 1445 0.447045857366028 2207 641818 SGTC_3240 9133527 49.47 µM 0.132817140035355 0.441417550880514 no 1446 0.447168999333667 2066 17617455 SGTC_1 0258-0098 57.368 µM 0.131042166727549 0.442150507334683 no 1447 0.447870975382539 2071 6790032 YDR047W HEM12 SGTC_3145 9085516 49.47 µM 0.130881183289369 0.442216993578088 no 1448 0.447934650093197 1961 25236195 SGTC_1774 st048371 48.465 µM 0.129958576861409 0.442598061849668 no 1449 0.448299599779267 2114 4242727 SGTC_1478 0453-0656 35.7 µM 0.129580263445018 0.442754333711704 no 1450 0.448449259532483 2157 5258496 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.129550889183016 0.442766467861605 no 1451 0.448460880217443 2197 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1451 4152-0210 104 µM 0.128729195798082 0.443105921106119 no 1452 0.44878596635254 2170 659563 SGTC_1457 k015-0032 57.3 µM 0.128596632217814 0.443160688928538 no 1453 0.44883841564132 2118 4302660 SGTC_1033 k072-0102 21.3 µM 0.128562646239597 0.443174730199946 no 1454 0.448851862467939 2194 5965931 SGTC_2018 5133068 143 µM 0.127862957023993 0.443463821900707 no 1455 0.449128713188015 2128 785362 SGTC_9 0092-0002 10.449 µM 0.127661500996859 0.443547063392689 no 1456 0.449208429242464 2174 759368 SGTC_1794 st048918 76.9 µM 0.127421084056867 0.443646406767148 no 1457 0.449303564794659 2183 672303 SGTC_2844 9010103 25.97 µM 0.12407024949419 0.445031380655396 no 1458 0.450629826793365 2069 2480525 SGTC_1900 st060200 72.8 µM 0.121278162690086 0.446185925198517 no 1459 0.451735357990835 2054 688945 SGTC_3215 9129942 49.47 µM 0.12025094684136 0.446610800438988 no 1460 0.452142180398942 2204 17682944 SGTC_2778 tioconazole 65.09 nM 0.119690192813662 0.446842764443585 no 1461 0.45236428475442 2160 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1111 tnp00062 510.699 nM 0.118330323146452 0.447405369557938 no 1462 0.452902965890338 2198 676306 SGTC_1266 0828-0227 32.9 µM 0.118223727400739 0.447449474825105 no 1463 0.452945195023453 2118 3913820 SGTC_400 oxethazaine 37.5 µM 0.117798273306245 0.447625518022513 no 1464 0.453113748862347 2087 4621 A local anesthetic. SGTC_2826 7992541 19.48 µM 0.117737447190101 0.447650687325393 no 1465 0.453137847277349 2217 2985066 SGTC_583 1488-1091 88.9 µM 0.11664992111525 0.44810073136983 no 1466 0.453568738199812 2220 4303273 SGTC_1907 st060210 83.7 µM 0.115597377392418 0.448536362515452 no 1467 0.45398582075525 2170 688793 SGTC_1050 3232-1156 69.3 µM 0.114796414115413 0.448867910117667 no 1468 0.454303245694193 2079 700529 SGTC_2493 resveratrol 26.09 µM 0.114489202633587 0.448995085522958 no 1469 0.454425002584282 2169 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1947 st076332 61.6 µM 0.114047698898087 0.449177862659262 no 1470 0.454599990916786 2211 24208416 SGTC_2138 5575593 77.673 µM 0.113936561470744 0.449223873892953 no 1471 0.454644041204465 2146 762213 SGTC_1625 st003711 30.1 µM 0.113812748085766 0.449275133815765 no 1472 0.45469311637523 2166 24207034 YER133W GLC7 SGTC_405 ebelactone b 50 µM 0.11359483573446 0.4493653536642 no 1473 0.454779490669577 2072 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_559 1550-0661 158 µM 0.113205146758123 0.449526698818351 no 1474 0.454933957688829 2124 5830875 SGTC_2224 6650123 117.647 µM 0.112312217228621 0.449896434961138 no 1475 0.455287927573245 2171 2908370 SGTC_2077 5212015 200 µM 0.111992104447974 0.450028994960278 no 1476 0.455414833462492 2220 780900 SGTC_181 1447-1644 8.07 µM 0.11189964456145 0.450067284012285 no 1477 0.455451489216626 2197 534600 SGTC_1240 0356-0016 42.1 µM 0.11148290026787 0.450239869956967 no 1478 0.455616712339184 2133 4305613 SGTC_1557 sumaresinolic acid 42.3 µM 0.110764687231641 0.450537324950814 no 1479 0.455901474249771 2158 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_528 3492-0019 172 µM 0.109938866915338 0.450879380889463 no 1480 0.45622892900596 2203 2869262 SGTC_651 3253-0966 34.4 µM 0.107562968143885 0.45186368410282 no 1481 0.45717118682305 2138 781462 SGTC_2839 9003951 25.97 µM 0.10632258981289 0.452377674302263 no 1482 0.457663204547988 2282 2990634 SGTC_2295 7971645 200 µM 0.1050608948207 0.452900579622502 no 1483 0.458163744468501 2148 2978226 YKL099C UTP11 SGTC_2907 7721985 69.9 µM 0.104350196414597 0.453195162252902 no 1484 0.458445722165021 2118 3267881 SGTC_2987 9018338 71.43 µM 0.103654601514786 0.453483509464041 no 1485 0.458721727624913 2241 5055682 SGTC_2737 bleomycin 30.5 nM 0.103500782370033 0.453547275929843 no 1486 0.458782764294496 2183 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2334 9017922 200 µM 0.10295507696565 0.453773510378374 no 1487 0.458999312402257 2199 3163164 SGTC_2096 5468907 200 µM 0.102640108371041 0.453904094525507 no 1488 0.45912430452589 2209 759785 SGTC_113 0099-0221 2.5 µM 0.101838076845152 0.454236634599107 no 1489 0.459442600899244 2217 89219 SGTC_2626 ethyl orsellinate 100 µM 0.101800240531464 0.454252323168869 no 1490 0.459457617363516 2172 75653 A natural product. SGTC_1203 3992-3522 103 µM 0.101442754381216 0.454400555885739 no 1491 0.459599499206274 2253 5322312 SGTC_1166 k206-0078 225 µM 0.101245607819485 0.454482306024051 no 1492 0.459677746446803 2203 5404595 SGTC_3342 9147791 14.508 µM 0.100438564497375 0.454816980178973 no 1493 0.459998077251499 2215 1838168 SGTC_1908 st060353 56.5 µM 0.0997769742376943 0.455091360093775 no 1494 0.460260694353975 2240 4227716 SGTC_471 1-acyl-paf 4 µM 0.0995156807894527 0.455199731676481 no 1495 0.460364419115509 2180 16759367 SGTC_1098 clofazimine 15.1 µM 0.0994749279001755 0.455216634257564 no 1496 0.460380596893128 2203 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2640 pentamidine 10.38 µM 0.0992341044003442 0.455316519350678 no 1497 0.460476198545468 2237 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1295 1013-0063 9.78 µM 0.0987418001102004 0.455520718587971 no 1498 0.460671639664115 2251 6826038 SGTC_3302 9125395 16.351 µM 0.0984286462253169 0.455650615478516 no 1499 0.460795964359488 2135 17599668 SGTC_2388 9080168 200 µM 0.0984052403427059 0.455660324478476 no 1500 0.460805256843511 2191 15943073 SGTC_3042 9091578 49.47 µM 0.098292485207813 0.455707096834837 no 1501 0.460850022611345 2216 25236497 SGTC_2598 perillyl alcohol 100 µM 0.0982435168557251 0.455727409761414 no 1502 0.460869464061261 2161 10819 An apoptosis inducer. SGTC_1310 1188-0297 994 nM 0.0976857304655627 0.455958797439365 no 1503 0.46109092339903 2168 1588352 SGTC_3243 9134147 49.47 µM 0.0973380802936234 0.456103021438283 no 1504 0.461228957932596 2245 24282180 SGTC_3181 9108277 49.47 µM 0.0941784429907848 0.45741407185311 no 1505 0.462483704326673 2197 17097298 SGTC_102 gallobenzophenone 83.616 µM 0.0931096182430957 0.4578576724302 no 1506 0.462908238189875 2241 70837 SGTC_380 3970-0968 6 µM 0.0927353024236563 0.458013039351977 no 1507 0.463056925282354 2192 2891601 SGTC_1127 asiatic acid 681.4 nM 0.0926231659592995 0.458059584980737 no 1508 0.463101469542613 2122 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1518 st038567 90.8 µM 0.092536548976269 0.458095538371215 no 1509 0.463135876949466 2241 77966 SGTC_631 k072-0230 41.5 µM 0.090832842142475 0.458802790458955 no 1510 0.463812706826494 2198 5773147 SGTC_1182 1222-0449 220 µM 0.090237511210198 0.459049958352367 no 1511 0.464049238135192 2186 658318 SGTC_1321 1326-2144 215 µM 0.0895300505924328 0.459343700523277 no 1512 0.464330336275776 2245 3513030 SGTC_1461 k072-0203 53.8 µM 0.0891604978884362 0.459497150004187 no 1513 0.464477179209626 2241 5418714 SGTC_2990 9074105 71.4286 µM 0.0867723873732549 0.46048891034367 no 1514 0.465426218250118 2264 6502001 SGTC_66 0109-0187 42.4 µM 0.0867677917219513 0.460490819114378 no 1515 0.465428044760827 2283 759417 SGTC_1082 camptothecin 424.86 nM 0.0865762263287516 0.460570385231722 no 1516 0.465504181785709 2254 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2487 5918373 44.05 µM 0.0865403374799756 0.460585291734197 no 1517 0.465518445829161 2279 2876279 SGTC_2303 7774051 200 µM 0.086266867636799 0.460698879777929 no 1518 0.465627138028203 2225 2953184 SGTC_3163 9099914 49.47 µM 0.0859425902571281 0.460833575322671 no 1519 0.465756027304165 2251 16268368 SGTC_1232 0279-0259 161 µM 0.0844683520008326 0.461445988136337 no 1520 0.46634203216806 2170 1560000 SGTC_597 k018-0003 82.8 µM 0.084165450198568 0.461571827841851 no 1521 0.466462443718377 2226 6786234 SGTC_607 4491-0986 66.8 µM 0.0839376671047857 0.461666462225496 no 1522 0.466552995600129 2257 698981 YDR232W HEM1 SGTC_1859 st055998 20 µM 0.0837506448516372 0.461744163801221 no 1523 0.466627344892452 2271 676301 SGTC_1080 nisoldipine 24.4 µM 0.0829605438052487 0.462072440798109 no 1524 0.466941456451849 2256 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1553 gossypol 38.6 µM 0.0825284055706891 0.462251999716942 no 1525 0.467113265497347 2245 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1378 2093-0007 380 nM 0.0819248301853991 0.462502805815426 no 1526 0.46735324458616 2178 3618014 SGTC_1985 st071382 65.5 µM 0.0811211800615674 0.462836772895814 no 1527 0.467672790971714 2272 6123237 SGTC_2963 9082507 9 µM 0.0789634107265219 0.463733590467963 no 1528 0.468530863082633 2222 16459611 SGTC_3171 9103192 49.47 µM 0.0787958714214076 0.463803231349336 no 1529 0.468597493983564 2271 13018434 SGTC_1197 1601-0112 267 µM 0.0787267550701342 0.463831961191434 no 1530 0.468624982027088 2237 7350313 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0785841784457535 0.463891227124893 no 1531 0.468681686193792 2236 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2942 9052777 62.25 µM 0.0780326205902683 0.464120504998834 no 1532 0.468901052308437 2228 6469503 SGTC_1021 4476-0760 85.3 µM 0.0774518051279359 0.464361957888386 no 1533 0.46913206499117 2208 746768 SGTC_2519 cryptotanshinone 88.04 µM 0.076234669067799 0.464867980373211 no 1534 0.469616200502806 2268 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_581 0958-0271 211 µM 0.0732045612031359 0.466127988219675 no 1535 0.470821668406881 2256 4591145 SGTC_143 4032-1194 15.74 µM 0.0730371833702752 0.46619759885175 no 1536 0.470888264230274 2257 1806963 SGTC_2952 9073731 13.78 µM 0.0715489972860299 0.46681656459051 no 1537 0.471480415125941 2229 16457353 SGTC_2655 perillic acid 100 µM 0.071007147998748 0.467041950331047 no 1538 0.471696033286434 2204 5702197 An apoptosis inducer. SGTC_2906 7926292 26.41 µM 0.0707940791467498 0.467130580606768 no 1539 0.47178082207966 2193 2966319 SGTC_2025 5147754 141 µM 0.070778420251276 0.467137094303722 no 1540 0.471787053443829 2269 315777 YLR208W SEC13 SGTC_423 5-fluorouracil 457 µM 0.0705874779365814 0.467216522093059 no 1541 0.471863038355563 2254 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3354 9151612 71.43 µM 0.0702057566920574 0.467375313617523 no 1542 0.472014946228005 2264 27261949 SGTC_706 4262-0057 46.9 µM 0.069242952471775 0.467775851796007 no 1543 0.472398117001955 2274 883298 SGTC_1415 3966-0071 78.1 µM 0.0690544652284119 0.467854268596213 no 1544 0.472473132971901 2279 2893185 SGTC_1286 0929-0070 131 µM 0.0679951579461311 0.468294997865373 no 1545 0.472894744382375 2236 1420408 SGTC_1657 st012939 43.4 µM 0.067858216791797 0.468351975659086 no 1546 0.472949250107905 2266 24207257 SGTC_2824 7998404 51.95 µM 0.0676394937550895 0.468442982195412 no 1547 0.473036307951617 2246 837851 SGTC_1188 1403-0014 4.57 µM 0.0660594374291946 0.469100462569648 no 1548 0.473665252259716 2226 9614867 SGTC_2728 chlorpromazine 9.18 µM 0.0651212519509616 0.469490892781113 no 1549 0.474038729867753 2299 2726 A thorazine and dopamine antagonist. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0648745851558971 0.469593549190896 no 1550 0.474136928031653 2276 16486 A toxic proline analog. SGTC_1875 nocodazole 6 µM 0.0646434455275477 0.46968974542561 no 1551 0.474228946249653 2311 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_650 1328-0195 38 µM 0.0646165142447693 0.469700953865467 no 1552 0.474239667861349 2295 2780821 SGTC_310 1273-0058 1.06 µM 0.0638858180254658 0.470005068996734 no 1553 0.47453057239293 2271 2734232 SGTC_3260 9137109 49.47 µM 0.0620431779135282 0.470772051507909 no 1554 0.475264223604826 2296 17478346 SGTC_3027 9089541 49.47 µM 0.0619721607616016 0.470801613952268 no 1555 0.475292500934594 2235 9943819 SGTC_2407 paclitaxel 400 µM 0.0610661034278066 0.471178794221284 no 1556 0.475653282147902 2195 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1096 rimcazole 32.2 µM 0.0609811466974238 0.471214161970305 no 1557 0.475687111931894 2264 18528119 A dopamine reuptake inhibitor. SGTC_3170 9103054 49.47 µM 0.0598437888332549 0.47168766931288 no 1558 0.476140024802516 2240 16432970 SGTC_1289 0976-0073 69.1 µM 0.0597800623980155 0.471714201233676 no 1559 0.476165402537288 2263 3391136 SGTC_1619 st003326 88.7 µM 0.0595928699867571 0.471792137814373 no 1560 0.476239948602052 2312 2849032 SGTC_1036 k216-0215 33.5 µM 0.0593513272841227 0.471892704450118 no 1561 0.476336139936882 2319 622330 SGTC_2093 5331342 194.4 µM 0.0591526863711676 0.471975410210018 no 1562 0.476415247208677 2302 33839 SGTC_1334 1486-0610 236 µM 0.0587235759892753 0.472154077928246 no 1563 0.476586140407617 2246 3742339 SGTC_2913 7966556 36.57 µM 0.0585110017056279 0.472242589079212 no 1564 0.476670799707815 2294 2976516 SGTC_2543 pimpinellin 60.67 µM 0.0584389948128552 0.472272571440973 no 1565 0.476699477230989 2269 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1079 idarubicin 2.36 µM 0.0573173974157163 0.472739604394618 no 1566 0.477146181000712 2311 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_87 0100-0052 35.5 µM 0.0570802089997227 0.472838374430814 no 1567 0.477240650822978 2297 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3104 9120930 49.47 µM 0.0569458338405071 0.472894331696496 no 1568 0.477294171700267 2212 17014836 SGTC_3084 9116877 49.47 µM 0.056681164989364 0.473004548163481 no 1569 0.477399589025989 2321 27241325 SGTC_1405 3909-7894 12 µM 0.0563617684882776 0.473137557703292 no 1570 0.477526806422367 2304 7104060 SGTC_2829 7992743 58.44 µM 0.0545595472535961 0.473888130759714 no 1571 0.478244683671317 2331 16462845 SGTC_217 ketoconazole 989 nM 0.0541430338693787 0.47406160983132 no 1572 0.478410603219979 2285 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2544 sphondin 68.51 µM 0.0536100006806308 0.474283626921181 no 1573 0.478622944290578 2292 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3177 9107506 49.47 µM 0.0532972689433185 0.474413888555278 no 1574 0.47874752808922 2308 8897194 SGTC_2584 androsterone 48.74 µM 0.0532015220484215 0.474453770398874 no 1575 0.47878567145772 2321 2754130 A steroid. SGTC_1379 2144-0755 36.5 µM 0.0528156862837536 0.47461448672973 no 1576 0.478939381548886 2299 5392327 SGTC_2982 9019404 25.97 µM 0.0524859407872805 0.474751842451414 no 1577 0.479070748760301 2264 22333232 SGTC_185 k048-0037 25.491 µM 0.0513582695029927 0.475221597310198 no 1578 0.479520018487633 2319 6827589 SGTC_1488 4013-0813 75.9 µM 0.0513279518746163 0.475234227225433 no 1579 0.479532097540051 2275 2910057 SGTC_1020 4335-0961 93.3 µM 0.0510697724104966 0.475341782316395 no 1580 0.479634961335902 2231 669075 SGTC_2783 7738165 71.43 µM 0.0510317624515066 0.475357617053043 no 1581 0.479650105368711 2244 17201110 SGTC_128 0906-2981 13.371 µM 0.0504605049851953 0.475595604397464 no 1582 0.479877710871734 2316 6740226 SGTC_3154 9100113 49.47 µM 0.0498344647072924 0.475856424399632 no 1583 0.480127150964228 2267 25237525 SGTC_2947 9072639 7.68 µM 0.048674987150707 0.47633951151505 no 1584 0.480589154801714 2296 16488146 SGTC_2038 4100038 30.985 µM 0.0480815726519888 0.476586766452053 no 1585 0.480825616055806 2276 3596803 SGTC_1017 4239-0030 168 µM 0.0474211813483931 0.476861938860432 no 1586 0.481088773867117 2233 1149593 SGTC_219 mitoxanthrone 164.414 µM 0.0446137905806314 0.478031846391358 no 1587 0.482207575155774 2298 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_285 1486-1325 46 µM 0.0428935324881115 0.478748813677069 no 1588 0.48289320216712 2325 22310230 SGTC_307 1501-1223 22.3 µM 0.0427386166498459 0.478813382740692 no 1589 0.482954948022148 2288 2830329 SGTC_1560 lithocholic acid 53.1 µM 0.0419593450278001 0.479138192267368 no 1590 0.483265553761545 2314 9903 A bile acid which acts as a detergent. SGTC_2551 apiole 73.87 µM 0.0413950418013089 0.479373409113821 no 1591 0.483490482740204 2328 10659 A possible DNA adduct former. SGTC_894 0960-0238 55.9 µM 0.041155688737518 0.479473180118517 no 1592 0.48358588949231 2320 6741907 YDL195W SEC31 SGTC_1637 st007924 17.4 µM 0.0410673656209543 0.479509996709761 no 1593 0.483621095553361 2337 683336 SGTC_2349 9023730 187.07 µM 0.0409884102553881 0.479542908597442 no 1594 0.483652567687465 2312 4126287 SGTC_43 0570-0105 72.5 µM 0.0409817679453547 0.479545677395517 no 1595 0.483655215361091 2338 1114046 YDL195W SEC31 SGTC_3065 9113888 49.47 µM 0.0401634221129055 0.479886806345625 no 1596 0.483981419505922 2301 16648368 SGTC_1357 1503-1303 39.5 µM 0.0382681126191201 0.480676925708206 no 1597 0.484736957299148 2324 292895 SGTC_719 2810-4230 27.3 µM 0.0349805620890147 0.482047622786029 no 1598 0.486047620296171 2351 721079 SGTC_445 e6 berbamine 66 µM 0.0345238304429237 0.48223806765939 no 1599 0.486229719863602 2308 6610268 A calcium/calmodulin antagonist. SGTC_820 1582-0060 59.9 µM 0.0341878645537879 0.482378159033753 no 1600 0.486363671784239 2306 3848840 SGTC_2120 5538279 151.968 µM 0.0336976493228165 0.482582573343512 no 1601 0.486559126739101 2329 2058197 SGTC_1842 st055362 61.2 µM 0.0336113956107025 0.482618540659238 no 1602 0.486593517510223 2315 676032 SGTC_862 0452-0056 10.2 µM 0.0335406096273357 0.482648058124249 no 1603 0.486621741118444 2336 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3130 9127414 49.47 µM 0.0324463957236566 0.483104352838071 no 1604 0.487058031755319 2359 1494646 SGTC_852 0418-0143 439 µM 0.0323245527604778 0.483155163570903 no 1605 0.487106614580895 2353 5369229 SGTC_1513 0337-0559 19 µM 0.0314044489809506 0.483538872365444 no 1606 0.48747349656453 2311 775073 SGTC_1471 k673-0312 37 µM 0.0313992725256377 0.483541031134336 no 1607 0.487475560653491 2349 24099884 SGTC_1710 st031758 61.5 µM 0.0312598448277565 0.483599177703209 no 1608 0.487531156965457 2340 5394341 SGTC_2861 9024595 19.48 µM 0.0303646873787342 0.48397250012105 no 1609 0.487888103625533 2356 16482810 SGTC_2035 5154463 94.595 µM 0.0285597857677543 0.484725270686068 no 1610 0.488607842649517 2345 2769623 SGTC_1727 st034309 9.9045 µM 0.028018450619715 0.484951056146163 no 1611 0.488823717728389 2358 870305 SGTC_1053 3366-3204 134 µM 0.0277475765451924 0.485064036821244 no 1612 0.488931738849705 2332 3632071 YPR165W RHO1 SGTC_1002 4049-0206 172 µM 0.0270189020961297 0.485367970434963 no 1613 0.489222328920942 2346 4662749 SGTC_619 1652-1634 108 µM 0.026999405351978 0.485376102738174 no 1614 0.48923010416 2335 5400454 SGTC_3046 9092212 49.47 µM 0.0267902020585761 0.485463364080414 no 1615 0.489313534019649 2359 25236637 SGTC_183 3914-0051 30.55 µM 0.026274272637522 0.485678567740203 no 1616 0.489519287643261 2351 1596232 SGTC_925 2064-1272 59.6 µM 0.0245487899411057 0.486398328285333 no 1617 0.490207433340112 2322 6815817 SGTC_2570 licareol 100 µM 0.0242667890441818 0.486515965220137 no 1618 0.490319901914618 2314 443158 SGTC_2800 7887935 81.82 µM 0.0233903470676812 0.486881581244972 no 1619 0.490669452412589 2329 2961002 SGTC_973 1325-0077 65.9 µM 0.022761082066864 0.487144091884712 no 1620 0.490920425993671 2341 2835149 SGTC_746 1095-0025 46.6 µM 0.0227538714989322 0.48714709995166 no 1621 0.490923301849281 2360 6749286 SGTC_2164 5685496 200 µM 0.0221035897514983 0.487418384069412 no 1622 0.491182661484565 2368 759046 SGTC_609 0986-0026 86.3 µM 0.0219963358137166 0.487463128760288 no 1623 0.491225439214516 2365 2848610 SGTC_1711 st032263 62.8 µM 0.0214550749110177 0.487688936868343 no 1624 0.491441320116114 2310 3958979 SGTC_1039 k821-0043 94 µM 0.0213739077471406 0.48772279926034 no 1625 0.491473693705758 2350 15992768 SGTC_2750 bromebric acid 70.15 µM 0.0202225997039151 0.488203126608162 no 1626 0.491932899807084 2347 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_995 3931-2021 34.6 µM 0.0191807144334206 0.488637817388474 no 1627 0.492348471213072 2339 730143 SGTC_415 dibenzyl ketone 100 µM 0.0189927229685048 0.488716251811296 no 1628 0.49242345529697 2364 7593 SGTC_2993 9054257 71.4286 µM 0.0186286634618418 0.488868147164936 no 1629 0.492568668332437 2383 6470217 YGL055W OLE1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0175209961088781 0.489330305418143 no 1630 0.493010491471983 2363 17037758 SGTC_1172 0370-0043 85 µM 0.0170687919519054 0.489518985244523 no 1631 0.493190867849527 2349 376585 SGTC_514 4466-0038 2.65 nM 0.0168759728055595 0.489599438743582 no 1632 0.493267780480764 2303 5722064 SGTC_985 1493-0307 8.71 µM 0.0164284477521425 0.489786169524957 no 1633 0.493446292392577 2372 3278274 SGTC_2796 7949634 45.45 µM 0.0151857868337991 0.490304684050509 no 1634 0.493941980409816 2379 2971588 SGTC_1307 1187-1599 12.2 µM 0.0145847218342468 0.490555491251216 no 1635 0.494181744084012 2353 1538471 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0145474767604289 0.490571032677144 no 1636 0.49419660114249 2356 368090 SGTC_743 1275-0778 158 µM 0.0142756318142128 0.490684467119709 no 1637 0.494305040323307 2376 2849257 YMR203W TOM40 SGTC_1013 4112-3890 241 µM 0.013908933083051 0.490837482986869 no 1638 0.494451317425034 2362 705171 SGTC_992 3909-8734 162 µM 0.0117020244097236 0.491758408440736 no 1639 0.495331674241628 2380 4288319 SGTC_1832 st054113 55 µM 0.0112479779946975 0.491947884012242 no 1640 0.49551280062693 2387 1251267 SGTC_969 1313-0238 134 µM 0.0104608701221171 0.4922763518789 no 1641 0.495826792730847 2383 5212874 SGTC_384 k007-0144 5.16 µM 0.00965124172138 0.492614223245692 no 1642 0.496149771391592 2376 6824886 SGTC_2442 5158906 48.48 µM 0.0091208393153629 0.49283557185924 no 1643 0.496361362013964 2379 1893835 SGTC_2340 7987427 183.45 µM 0.00854609598877368 0.493075427404404 no 1644 0.496590642478594 2388 2239331 SGTC_1733 st037357 54.9 µM 0.00831070116868818 0.493173664597375 no 1645 0.496684548089209 2390 1272339 YGL099W LSG1 SGTC_2168 5727979 200 µM 0.00813593545382951 0.493246599746769 no 1646 0.496754267164597 2385 695210 SGTC_3335 9143315 29.6265 µM 0.00773014351293001 0.49341595016713 no 1647 0.496916149631793 2378 4899691 SGTC_2927 9011802 47.9 µM 0.0067932642315146 0.493806945410717 no 1648 0.497289900520603 2386 43912568 SGTC_448 monastrol 171 µM 0.00646672252513915 0.493943225062251 no 1649 0.497420168949888 2359 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_39 0986-0283 58.349 µM 0.00559010129154851 0.494309079595082 no 1650 0.497769883857984 2388 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_161 4065-0411 162.148 µM 0.00478287974725134 0.494645974672458 no 1651 0.498091914321624 2383 1906281 YLR208W SEC13 SGTC_1137 ixabepilone 100 µM 0.00407968001338337 0.494939459217628 no 1652 0.498372447666927 2400 154225 A novel microtubule stabilizer. SGTC_1338 1486-1223 76 µM 0.00388173792609112 0.495022072012939 no 1653 0.498451414508831 2384 3444526 SGTC_3312 9133330 71.43 µM 0.00384822966342403 0.495036056989475 no 1654 0.498464782271706 2392 17617324 SGTC_2098 5376439 882.5 nM 0.00195236067280489 0.495827324481197 no 1655 0.499221121275835 2401 2844116 SGTC_571 k831-0106 44.2 µM 0.00169051860730006 0.49593660929718 no 1656 0.499325580972974 2400 4783639 SGTC_2391 6285546 200 µM -0.000525549643078848 0.496861539346545 no 1657 0.499790336036578 2408 846083 SGTC_1720 st037298 9.481 µM -0.001938603421098 0.497451320873187 no 1658 0.499226609614817 2411 597396 SGTC_1114 scopoletin 1.73284 µM -0.00241622289951014 0.497650671400628 no 1659 0.499036067464439 2412 5280460 A coumarin with genotoxic properties. SGTC_3060 1327-0027 12.5 µM -0.00241761714004438 0.497651253334615 no 1660 0.499035511244566 2405 16000455 YPR107C YTH1 SGTC_1629 st005085 44.9 µM -0.00244207216404079 0.497661460476361 no 1661 0.499025755130326 2410 24207091 SGTC_1777 st045864 34.765 µM -0.00278806468412994 0.497805872464309 no 1662 0.498887724558016 2410 4691462 SGTC_1941 st076221 61.8 µM -0.00363311381476466 0.498158584221751 no 1663 0.498550600478343 2411 2828568 SGTC_1624 st003710 6.25 µM -0.00380850105998334 0.498231788608794 no 1664 0.498480631575212 2405 24207033 SGTC_1672 st016598 6.51 µM -0.00383564269604201 0.498243117185011 no 1665 0.498469803708118 2426 4665860 YNL267W PIK1 SGTC_1152 3909-8331 15.9 µM -0.0040567263848831 0.498335394777421 no 1666 0.498381604764048 2416 16001939 SGTC_2956 9076196 2.52 µM -0.00441849310380548 0.498486391913314 no 1667 0.498237282020846 2410 16423868 SGTC_396 dithiazanine 1.25 µM -0.00507391851015688 0.498759959238289 no 1668 0.497975808064343 2420 10578 An antihelmenthic. SGTC_153 4077-0274 519.67 µM -0.00541901933643734 0.498904000753795 no 1669 0.497838134649194 2417 3121976 SGTC_3118 9124250 49.47 µM -0.00610996859577589 0.499192396238702 no 1670 0.497562490361299 2437 1504786 SGTC_321 4534-3890 65.3 µM -0.00630373849155901 0.499273273986439 no 1671 0.497485188846359 2427 699746 SGTC_2176 5809774 33.9695 µM -0.00679472107249848 0.499478205663784 no 1672 0.497289319338552 2423 2870539 SGTC_97 0535-0701 19.132 µM -0.00686395208175471 0.499507102071624 no 1673 0.49726170080592 2422 2832013 YGL099W LSG1 SGTC_70 0141-0289 43.283 µM -0.00693425515798381 0.499536445953333 no 1674 0.49723365460385 2450 352408 SGTC_3082 9117008 49.47 µM -0.00725474916121391 0.499670217342724 no 1675 0.49710579921354 2431 41448529 SGTC_2974 9094440 9.66 µM -0.00782304934150048 0.49990742094125 no 1676 0.49687908668941 2480 25236134 SGTC_1924 st058459 75.1 µM -0.00785684256238897 0.499921525942331 no 1677 0.49686560555912 2429 688683 SGTC_2189 6047310 154.431 µM -0.00823286396156553 0.499921525942331 no 1678 0.496715599579784 2404 711535 SGTC_1983 st071813 46.9 µM -0.00933429319541905 0.499461798962086 no 1679 0.496276209861799 2447 11838595 SGTC_1799 st045822 46.1415 µM -0.0106810507429724 0.498899675110763 no 1680 0.495738958279717 2424 3674992 SGTC_2457 5731572 11.68 µM -0.0114402416054176 0.498582796922938 no 1681 0.495436103478941 2422 2865357 SGTC_692 k241-0027 77.8 µM -0.0117161506076888 0.498467635652207 no 1682 0.495326039090308 2430 3600480 SGTC_554 4483-2211 187 µM -0.0123259243013669 0.498213123533773 no 1683 0.495082792162067 2445 747107 SGTC_2063 5246145 200 µM -0.0128995135709457 0.497973715015517 no 1684 0.494853981354397 2446 711240 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0161319134920242 0.49662457049319 no 1685 0.493564576769754 2450 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1122 capsaicin 818.572 nM -0.0169269088649345 0.496292759306348 no 1686 0.493247462835248 2471 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3255 9139072 49.47 µM -0.0175863044865893 0.496017546000423 no 1687 0.492984441212605 2465 17646060 SGTC_3134 9127454 49.47 µM -0.0176455323516058 0.495992826035488 no 1688 0.492960816378996 2431 24262820 SGTC_2073 5212005 126 µM -0.0195253023939082 0.495208273930638 no 1689 0.492211026248652 2433 691789 SGTC_861 0443-0273 110 µM -0.0214740978011589 0.494394932590835 no 1690 0.491433732828983 2498 6149169 SGTC_1833 st055984 71 µM -0.0214744545464227 0.49439478370311 no 1691 0.491433590541025 2449 676288 SGTC_449 xestospongin c 11.1929 µM -0.0215025865833492 0.494383042792914 no 1692 0.491422370072923 2475 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2213 7173844 200 µM -0.0216599397506246 0.494317371512918 no 1693 0.491359609858622 2435 892728 SGTC_569 4130-2812 160 µM -0.0227287078407387 0.493871325754049 no 1694 0.490933338100923 2444 743552 SGTC_3290 9121031 71.43 µM -0.0228123683907675 0.493836410699992 no 1695 0.490899971021818 2453 17014854 SGTC_648 0375-0473 33.3 µM -0.0229395120742917 0.493783348402281 no 1696 0.490849261300962 2448 1713139 SGTC_755 1995-0008 37.3 µM -0.0230426233673942 0.493740315892008 no 1697 0.490808136717016 2436 689533 SGTC_1616 st002734 56.1 µM -0.0230429287139656 0.49374018845865 no 1698 0.490808014933695 2463 4026101 SGTC_3273 9137859 49.47 µM -0.0235466193659342 0.493529979048314 no 1699 0.490607125951751 2440 2377234 SGTC_552 k242-0005 476 µM -0.0236266416704543 0.493496582838093 no 1700 0.49057521055008 2477 4088318 SGTC_215 1287-0124 461.5 µM -0.024333376455923 0.493201638783139 no 1701 0.490293345222679 2512 5560863 SGTC_410 α-linolenic acid 100 µM -0.0245516910369434 0.493110529553197 no 1702 0.490206276319052 2534 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2409 alverine citrate 63.97 µM -0.0250820136622685 0.492889211504095 no 1703 0.489994773343883 2660 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_123 0083-0120 66.675 µM -0.0255101399525693 0.492710544357553 no 1704 0.489824030303884 2459 16001701 SGTC_2199 6590217 200 µM -0.0266428734874752 0.492237835222696 no 1705 0.489372288643233 2466 703109 SGTC_2344 7990960 76.95 µM -0.0268128746345324 0.492166891752375 no 1706 0.489304492218542 2474 140813 SGTC_668 1682-0499 62.6 µM -0.0270213995168253 0.492079872214598 no 1707 0.489221332957871 2480 682214 SGTC_825 1988-2224 89.6 µM -0.0270947098233804 0.492049279173177 no 1708 0.489192097081316 2454 1180859 SGTC_2050 5263056 171 µM -0.0271087526557662 0.492043418979949 no 1709 0.489186496858811 2462 763468 YGL055W OLE1 SGTC_1605 st000082 49.1 µM -0.0280764127725838 0.491639610399581 no 1710 0.488800603268331 2548 1114022 SGTC_1361 1608-0041 5.61 µM -0.0283990672596456 0.491504967228132 no 1711 0.488671934060746 2456 X1361 SGTC_2518 prenyletin 46.28 µM -0.0301328312834092 0.490781487392157 no 1712 0.487980558517511 2472 3873459 A coumarin with calcium channel inhibitory activity. SGTC_522 1273-0010 11.6 µM -0.0302577085996695 0.490729378663207 no 1713 0.48793076238232 2627 5705015 SGTC_1765 st044815 90.4 µM -0.0311191782081738 0.490369909518367 no 1714 0.487587247538715 2496 645695 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0311803656381012 0.490344377869231 no 1715 0.487562849125755 2459 688667 SGTC_1044 1222-0021 1.78 µM -0.0312959352649984 0.490296154295223 no 1716 0.48751676600523 2566 4306703 SGTC_47 0149-0135 24.25 µM -0.0318882140533671 0.490049017208135 no 1717 0.487280598842029 2444 5239155 SGTC_627 1391-0720 175 µM -0.0326286840490798 0.48974005053209 no 1718 0.486985347720355 2492 997839 SGTC_1997 st073024 93.8 µM -0.0328593025197553 0.489643824488942 no 1719 0.486893393570379 2455 686268 SGTC_2531 methyl deoxycholate 70.07 µM -0.0334429286978387 0.489400307941273 no 1720 0.486660688321555 2480 16667744 Haematoxylin. SGTC_2891 9063876 19.48 µM -0.0335817569014867 0.489342382802524 no 1721 0.48660533497322 2465 6472478 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0337039456164061 0.489291400565024 no 1722 0.486556616307387 2500 5393153 SGTC_1571 st070080 73.4 µM -0.0339486662176708 0.489189293431535 no 1723 0.486459042751629 2497 4315245 SGTC_1206 3978-0017 132 µM -0.0353259221558099 0.48861466107817 no 1724 0.485909926668017 2619 3873677 SGTC_3049 9092223 49.47 µM -0.0365583644324171 0.488100469314972 no 1725 0.485418570845302 2526 8623917 SGTC_533 1222-0222 6.71 µM -0.0378550763675999 0.487559484740675 no 1726 0.484901615609831 2618 3982874 SGTC_1455 4262-0120 131 µM -0.0381963753395812 0.487417099533619 no 1727 0.484765555424387 2616 1529587 SGTC_3004 9076122 71.4286 µM -0.039176679092522 0.487008139359003 no 1728 0.484374763373737 2486 44782551 SGTC_1850 st056238 17 µM -0.0399204185294156 0.486697877466312 no 1729 0.484078286222406 2472 5393177 SGTC_2965 9082772 38.63 µM -0.0402157261077371 0.486574687770335 no 1730 0.483960570075773 2497 16459634 SGTC_1955 wogonin 32.4 µM -0.0402938418639049 0.486542101430431 no 1731 0.483929431637208 2651 5281703 A flavanone. SGTC_347 4534-1311 26.2 µM -0.0406351437947047 0.486399726847939 no 1732 0.483793383293985 2479 2862016 SGTC_1868 st057644 42.7 µM -0.041344836734951 0.486103683006353 no 1733 0.483510494531724 2485 688665 SGTC_760 0568-0725 82.9 µM -0.0413604442203466 0.486097172529754 no 1734 0.483504273367406 2479 3916171 SGTC_1145 3546-0597 10.2 µM -0.041476790039264 0.486048640374319 no 1735 0.483457897896786 2525 875334 SGTC_3264 9137442 49.47 µM -0.041838345515729 0.48589782349985 no 1736 0.483313783230468 2499 17015726 SGTC_2525 harmine 47.85 µM -0.0418945621698712 0.485874373834978 no 1737 0.483291375676858 2526 5280953 A monoamine oxidase inhibitor SGTC_166 k072-0058 166.424 µM -0.0419697552306423 0.485843008613957 no 1738 0.483261404346701 2474 5846229 SGTC_1522 st012842 45.6 µM -0.0427524959204879 0.485516509856172 no 1739 0.482949416050538 2476 3491067 YOR116C RPO31 SGTC_2749 bexarotene 57.39 µM -0.0428509036614101 0.485475462455263 no 1740 0.482910192986484 2509 82146 An retinoic acid receptor inhibitor. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0428792276554616 0.485463648104854 no 1741 0.482898903723996 2487 16623 A steroid. SGTC_2426 5582046 32.21 µM -0.04355834590477 0.485180381837282 no 1742 0.482628227657211 2519 2251934 SGTC_2062 5245942 200 µM -0.0438118852865866 0.485074630213456 no 1743 0.482527176546776 2472 1376160 SGTC_2260 7964312 200 µM -0.0448877919886298 0.48462587982103 no 1744 0.482098373809465 2609 231951 SGTC_2129 girgensonine 121.053 µM -0.0452020793870364 0.484494797203237 no 1745 0.481973118417531 2533 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1161 k007-0610 110 µM -0.0456460229839052 0.484309640589406 no 1746 0.481796193171126 2484 5843850 SGTC_2021 4019055 173 µM -0.0491548775317448 0.482846316537232 no 1747 0.480397935140318 2542 44827708 YER133W GLC7 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0492353800229462 0.482812746612629 no 1748 0.48036585813216 2492 5106787 A p450 inhibitor. SGTC_2415 st077333 57.7 µM -0.0493490655171625 0.482765339424351 no 1749 0.480320559247192 2495 2766255 SGTC_893 0958-0369 48.9 µM -0.0494781035215707 0.482711530489079 no 1750 0.480269143340992 2607 6819948 SGTC_2761 levamisole 97.89 µM -0.0505029254938905 0.482284190294747 no 1751 0.479860809087271 2512 26879 An alkaline phosphatase inhibitor. SGTC_3121 9125696 49.47 µM -0.0507598719855739 0.482177049429463 no 1752 0.479758433574139 2472 1235365 SGTC_2034 5197015 53.07 µM -0.0521351122897576 0.48160362745404 no 1753 0.479210517718264 2546 780676 SGTC_265 mycophenolic acid 32.932 µM -0.05262361512114 0.481399949780942 no 1754 0.479015900445619 2571 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1696 st025591 34.7925 µM -0.0537251170100051 0.480940704544147 no 1755 0.478577085608473 2502 2787147 SGTC_3097 9117246 49.47 µM -0.0541523256526461 0.480762596749025 no 1756 0.478406901765032 2501 16423892 SGTC_2885 9057732 51.95 µM -0.0543219142399656 0.480691894538672 no 1757 0.478339345144947 2562 6471414 SGTC_106 0092-0003 11.579 µM -0.0549184746481429 0.48044319078357 no 1758 0.478101706724497 2596 1072148 SGTC_1025 k007-0731 70 µM -0.0549940721300883 0.480411675023605 no 1759 0.478071593201328 2506 6256118 SGTC_26 0302-0163 425.158 µM -0.0550455493008573 0.480390214826527 no 1760 0.478051087841638 2512 3100915 SGTC_2545 solidagenone 89.61 µM -0.0550905959091334 0.480371435498203 no 1761 0.47803314407282 2490 6708572 An anti ulcer agent SGTC_2831 7999036 19.48 µM -0.0555528216952574 0.480178742276304 no 1762 0.477849024628955 2601 2988270 SGTC_311 1315-0136 58 µM -0.0561960084408094 0.479910617556248 no 1763 0.477592830471367 2580 6759207 SGTC_2766 oltipraz 83.91 µM -0.0565603202219736 0.479758751233628 no 1764 0.477447721896377 2537 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_864 0469-0573 172 µM -0.0572360997511572 0.479477054849043 no 1765 0.477178560919608 2508 689425 SGTC_1945 st075991 56.6 µM -0.0583034128170519 0.479032169983336 no 1766 0.476753474553364 2550 1084980 SGTC_2386 9075165 157.42 µM -0.0605989464081019 0.478075418910627 no 1767 0.475839306314177 2524 16452277 SGTC_3245 9134821 49.47 µM -0.0608330384336905 0.477977859147266 no 1768 0.475746089085799 2504 17014901 SGTC_3111 9122088 49.47 µM -0.0608621975345488 0.477965706946166 no 1769 0.475734477802514 2573 16876704 SGTC_1180 1193-0155 285 µM -0.0612772552207084 0.477792731806494 no 1770 0.475569202229992 2572 2921347 SGTC_2293 7624732 200 µM -0.0615053606607727 0.477697670726584 no 1771 0.475478372650602 2512 894453 SGTC_95 0471-0001 561.058 µM -0.0615491480028195 0.477679422854268 no 1772 0.475460937061876 2536 4015405 SGTC_2837 9008476 45.46 µM -0.0616288102285707 0.477646224655891 no 1773 0.475429216649938 2609 2992805 SGTC_3209 9113616 49.47 µM -0.0626681949785297 0.477213088854969 no 1774 0.475015362161737 2528 16649353 SGTC_549 1661-1316 519 µM -0.0629165198831791 0.47710961005582 no 1775 0.474916489971111 2527 2857282 SGTC_622 1348-1566 26.3 µM -0.0640619136152329 0.476632336218793 no 1776 0.47446046402845 2581 7340407 SGTC_510 ag-490 170 µM -0.0643599933119263 0.476508134931118 no 1777 0.474341792331756 2517 5328779 SGTC_3053 9095903 49.47 µM -0.0644749042969602 0.47646025541771 no 1778 0.474296044497687 2537 17174018 SGTC_266 formosanin C 406 nM -0.0649896657058354 0.476245775963611 no 1779 0.474091114216194 2530 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_900 1112-0045 141 µM -0.0652524400243367 0.476136291593448 no 1780 0.473986504477923 2536 56211 YIL048W NEO1 SGTC_964 1287-0107 19.4 µM -0.0658360516676951 0.475893137478873 no 1781 0.473754176703362 2571 51516812 YPR165W RHO1 SGTC_1685 st024049 53.0905 µM -0.066233200180825 0.47572767590225 no 1782 0.473596082437648 2580 1941139 SGTC_2945 9067681 61.76 µM -0.0668032438167325 0.475490189401627 no 1783 0.473369170494061 2512 16456930 SGTC_3347 9188721 44.724 µM -0.0672731902637793 0.475294411044257 no 1784 0.473182109797988 2571 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_771 0250-0039 27.3 µM -0.0674091060042177 0.475237790042117 no 1785 0.473128010068315 2522 3005115 SGTC_2912 7964298 10.93 µM -0.0675818440940522 0.475165829976133 no 1786 0.473059254332594 2574 2975850 SGTC_778 3456-2434 196 µM -0.0676215706967745 0.475149280590997 no 1787 0.473043441883797 2686 5539063 SGTC_2403 6032726 181.2 µM -0.0681867459028472 0.474913843466061 no 1788 0.472818488825981 2566 2881040 SGTC_2827 7993847 71.43 µM -0.0697346290774442 0.474269081141537 no 1789 0.472202439421791 2586 2985692 SGTC_3138 9097216 49.47 µM -0.0700405290807685 0.474141668079184 no 1790 0.472080700643443 2515 25237486 SGTC_2817 7995342 71.43 µM -0.0702251751793237 0.474064760811187 no 1791 0.472007218445714 2530 18879975 SGTC_2643 anethole 100 µM -0.0722138602092179 0.473236512000937 no 1792 0.471215857560209 2540 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2848 9016370 25.97 µM -0.0734349463107522 0.472728010380034 no 1793 0.470730004760389 2533 7894410 SGTC_680 0417-1641 114 µM -0.0745059129415382 0.472282060147429 no 1794 0.470303918199614 2543 2835990 SGTC_2009 4012297 12.05 µM -0.0747892916134949 0.472164067130586 no 1795 0.470191181005087 2605 45595307 SGTC_2166 5933061 31.504 µM -0.0762660115782239 0.471549231254233 no 1796 0.469603732946855 2839 2877375 SGTC_272 doxorubicin 8.13 µM -0.0778323359131047 0.470897162511112 no 1797 0.468980712060862 2516 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2056 5235370 200 µM -0.0786558444970907 0.47055436290402 no 1798 0.468653183800272 2597 5511916 SGTC_3287 9117173 37.0625 µM -0.0801769708367477 0.469921225472598 no 1799 0.468048252897963 2543 2789709 SGTC_1195 1502-0147 41.1 µM -0.0803621167191845 0.469844167480773 no 1800 0.467974627950117 2539 817940 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.081428934866682 0.469400178270897 no 1801 0.467550419407566 2587 551469 SGTC_1142 3253-1408 9.78 µM -0.0816619010904314 0.46930322724823 no 1802 0.467457787827814 2530 256655 SGTC_2957 9076800 11.52 µM -0.0826474244583823 0.468893112897319 no 1803 0.467065945485712 2605 16459615 SGTC_817 1391-0715 46 µM -0.0827191827617617 0.468863252778601 no 1804 0.467037415753565 2610 1353946 SGTC_2665 lovastatin 100 µM -0.0828611871656616 0.468804162316558 no 1805 0.466980958011565 2564 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1951 sophoraflavanone G 9.2 µM -0.0843039071830136 0.468203861014626 no 1806 0.466407402990325 2553 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2360 9040895 200 µM -0.0861790850944123 0.46742372657404 no 1807 0.465662028260483 2599 4914414 SGTC_878 0828-0289 13.7 µM -0.086341878388985 0.467356005176574 no 1808 0.465597324307617 2579 745350 YLR208W SEC13 SGTC_2589 lobaric acid 100 µM -0.0881280148148668 0.466613041631271 no 1809 0.464887465199044 2606 73157 A novel microtubule depolymerizer. SGTC_1845 st056753 3.01 µM -0.0882918640680778 0.466544892476278 no 1810 0.46482235261809 2526 5375839 SGTC_220 paclitaxel 373.376 µM -0.0887754385938222 0.466343767012795 no 1811 0.464630188883204 2655 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_349 k015-0014 24 µM -0.0888794630247921 0.466300502906775 no 1812 0.464588852540028 2554 2196908 SGTC_2802 7925815 54.55 µM -0.0894012417261621 0.466083499432014 no 1813 0.464381518334956 2585 1262923 SGTC_2299 7976368 114.88 µM -0.0901186892786414 0.465785135367034 no 1814 0.464096448875721 2630 2979718 SGTC_1061 3448-9325 110 µM -0.0915911378446538 0.465172850341797 no 1815 0.463511446414314 2546 723482 SGTC_1756 st041558 35.5 µM -0.0916713808344811 0.465139485432911 no 1816 0.463479568203599 2630 3955792 SGTC_2416 tofa 880 nM -0.092494156605603 0.464797390743381 no 1817 0.463152716837002 2622 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1887 st057648 70.8 µM -0.0928805754200527 0.464636734032542 no 1818 0.462999218799873 2704 688672 SGTC_3355 9151058 44.0485 µM -0.0937270576664137 0.464284822454895 no 1819 0.462662987987919 2571 17015728 SGTC_2435 5706476 10.6 µM -0.0953724341045736 0.463600863456339 no 1820 0.462009505325357 2605 5725375 SGTC_1919 st067113 52.3 µM -0.0954868824175664 0.463553292939172 no 1821 0.461964054482617 2680 1268243 SGTC_2675 theaflavin digallate 100 µM -0.0956086194878603 0.463502693417168 no 1822 0.461915709601865 2596 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_577 r071-0003 38.6 µM -0.0968428867374867 0.46298970869469 no 1823 0.461425582642169 2579 4568517 YMR134W ERG29 SGTC_1981 st071826 47 µM -0.098399834415525 0.462342699788464 no 1824 0.460807403080165 2654 11838600 SGTC_687 k029-0044 34.9 µM -0.099839725600386 0.461744423792626 no 1825 0.460235784563767 2600 5829338 SGTC_1867 st057372 64 µM -0.101345176179364 0.461119000389932 no 1826 0.459638227685438 2575 688837 SGTC_1732 st034308 51.822 µM -0.10138013760887 0.461104477173013 no 1827 0.459624351560786 2550 830119 SGTC_707 0865-0008 204 µM -0.101842245344529 0.460912519340962 no 1828 0.459440946510061 2602 723043 SGTC_823 0417-1665 178 µM -0.103408793043514 0.460261849294688 no 1829 0.458819266861029 2668 3429856 SGTC_480 am 92016 50 µM -0.103522620237071 0.460214574971212 no 1830 0.458774098794593 2654 2129 K+ channel blocker. SGTC_667 1498-1044 59 µM -0.10492988864753 0.459630159698483 no 1831 0.45821572108296 2634 6739982 SGTC_3148 9097893 49.47 µM -0.104971215639753 0.45961299859489 no 1832 0.458199324548342 2619 17174100 SGTC_2652 actinonin 100 µM -0.105254313691943 0.45949544367358 no 1833 0.458087006964502 2576 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2635 hydroquinidine 100 µM -0.105433451823736 0.459421059370604 no 1834 0.458015936631463 2605 442912 An experimental heart treatment. SGTC_783 0848-0141 92.7 µM -0.105928622701278 0.459215454818676 no 1835 0.457819492096621 2584 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2887 9044784 58.44 µM -0.105941510024294 0.459210103897623 no 1836 0.45781437956624 2608 6465546 SGTC_2709 st078560 56 µM -0.106504707280969 0.458976267059631 no 1837 0.457590960391764 2638 17250903 SGTC_2448 5185112 27.17 µM -0.106756425899291 0.458871759264203 no 1838 0.457491108471116 2707 5718189 SGTC_3166 9102297 49.47 µM -0.107226904638919 0.458676434912035 no 1839 0.457304485829137 2645 25237072 SGTC_2973 9094665 17.96 µM -0.107592519126905 0.458524652977982 no 1840 0.457159465707174 2842 25237061 YIL048W NEO1 SGTC_960 1222-0186 7.7 µM -0.107763343930716 0.458453738496599 no 1841 0.457091710406915 2704 3126296 SGTC_1817 st052116 64.4 µM -0.108142895006985 0.458296180237572 no 1842 0.456941171179279 2696 4361398 SGTC_2126 5251174 33.877 µM -0.108750253607371 0.45804406875142 no 1843 0.456700290786826 2643 790722 SGTC_1879 gemcitabine 100 µM -0.109360000102135 0.457790983041037 no 1844 0.456458479351496 2606 60750 A nucleoside analog which inhibits DNA replication. SGTC_637 1181-0519 7.26 µM -0.109978928112538 0.457534103888262 no 1845 0.456213043228618 2603 6252091 YGR060W ERG25 SGTC_257 daunorubicin 18.5 µM -0.110452408387612 0.457337603162834 no 1846 0.456025295730518 2731 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1199 1638-0010 4.46 µM -0.112760847268875 0.45637972002752 no 1847 0.455110079830347 2599 3111136 SGTC_1874 staurosporine 7.6 µM -0.113208549890441 0.456193975688199 no 1848 0.454932608707348 2705 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2914 7968218 45.32 µM -0.113491517664544 0.45607658201998 no 1849 0.454820443778495 2688 2977111 SGTC_110 0850-0284 111.64 µM -0.115298193024319 0.455327144918302 no 1850 0.454104385284932 2583 3906265 SGTC_2674 ligustilide 100 µM -0.115487121575458 0.455248783544403 no 1851 0.454029513835158 2696 5319022 A signalling regulator. SGTC_2012 4023501 200 µM -0.115665154172815 0.455174943048563 no 1852 0.453958961892882 2666 3477460 SGTC_1995 st072814 61.1 µM -0.115716905095954 0.455153479214515 no 1853 0.453938453965152 2623 5769371 SGTC_2058 5236698 133 µM -0.116225895886185 0.45494238090599 no 1854 0.453736756940032 2639 766665 SGTC_1162 k048-0130 20.1 µM -0.116454256899084 0.454847674829296 no 1855 0.453646268534702 2617 6797406 SGTC_3298 9116858 71.43 µM -0.119051503961871 0.453770724164067 no 1856 0.452617275815449 2728 2506942 SGTC_730 1436-0052 41.2 µM -0.119412436223058 0.453621090015822 no 1857 0.452474304555786 2614 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2692 st077426 47.7 µM -0.119906983806018 0.45341607274767 no 1858 0.45227841605879 2674 25238571 SGTC_2782 7736369 71.43 µM -0.121710905810221 0.452668353151465 no 1859 0.451563987933868 2661 2950836 YOL077C BRX1 SGTC_2608 thymoquinone 42.66 µM -0.122102173169851 0.452506196203513 no 1860 0.451409050409223 2592 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2516 gossypol 71.55 µM -0.122432507508024 0.452369298518839 no 1861 0.451278247445315 2722 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1105 epirubicin 18.1 µM -0.124285944431027 0.451601299695564 no 1862 0.450544437865256 2627 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2582 agaric acid 100 µM -0.125613246593466 0.451051423658159 no 1863 0.450019038375731 2687 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2480 5767542 37.17 µM -0.125797029343759 0.450975293339578 no 1864 0.449946296667041 2674 2867358 SGTC_2776 terbinafine 19.92 µM -0.125894766026447 0.450934807549625 no 1865 0.449907612909022 2608 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2496 diffractaic acid 79.83 µM -0.126942331516683 0.450500903165979 no 1866 0.449493020965693 2831 94870 An apoptosis inducer which activates caspases. SGTC_2804 7954240 19.48 µM -0.12749871832573 0.450270470304992 no 1867 0.449272843766019 2738 828705 SGTC_1370 2001-0092 44.6 µM -0.127730295698026 0.45017456528161 no 1868 0.449181206981144 2712 790957 SGTC_1269 0831-0796 3.05 µM -0.129216319415223 0.44955921565532 no 1869 0.448593241719978 2721 927758 SGTC_1484 3473-2379 286 µM -0.13044281055196 0.449051427525717 no 1870 0.448108048994364 2629 671917 SGTC_1047 2043-3044 82 µM -0.134161847103314 0.447512196807958 no 1871 0.446637297353179 2645 669592 SGTC_629 3448-6466 76.7 µM -0.134391764807847 0.447417064420191 no 1872 0.446546396646733 2676 573744 SGTC_2134 5324836 1.464 µM -0.135114829996763 0.447117903556181 no 1873 0.446260542529124 2695 699272 SGTC_1975 st070967 30.8 µM -0.135129304846642 0.447111915040953 no 1874 0.446254820376127 2688 261391 SGTC_1419 3993-2473 62.6 µM -0.137168611571037 0.446268336985216 no 1875 0.445448760348731 2673 704026 SGTC_1205 4161-2785 76 µM -0.138075606615987 0.445893227996083 no 1876 0.445090332099751 2805 3498106 SGTC_3176 9106582 49.47 µM -0.138429194197026 0.445747006691775 no 1877 0.444950612744238 2646 17018027 SGTC_2266 7929956 200 µM -0.139354319921205 0.445364468570646 no 1878 0.444585083744738 2634 2967153 SGTC_1656 st012921 11 µM -0.139541634039704 0.445287020639729 no 1879 0.444511079268439 2758 6732821 SGTC_3150 9097574 49.47 µM -0.139772195729296 0.445191694196249 no 1880 0.44441999110212 2718 17217476 SGTC_3310 9130229 44.1445 µM -0.13989340483478 0.445141581187398 no 1881 0.444372106113815 2799 7761258 SGTC_613 3914-0030 117 µM -0.139956843958012 0.445115353100185 no 1882 0.444347044115107 2608 1145395 SGTC_212 3807-4682 38.772 µM -0.141372020572916 0.44453032925101 no 1883 0.443788028301294 2728 3125501 YBL034C STU1 SGTC_145 3737-0113 38.366 µM -0.141676187355282 0.444404604618888 no 1884 0.443667892461098 2775 6849351 SGTC_1650 st011916 45.8 µM -0.143603890788711 0.443607936142249 no 1885 0.442906634050597 2691 242528 SGTC_1223 0764-0573 147 µM -0.1443201739179 0.44331197329768 no 1886 0.442623824294088 2669 1609797 SGTC_3271 9137798 49.47 µM -0.145915507725659 0.442652907156083 no 1887 0.441994044612595 2731 6498326 SGTC_2664 lyso-paf C-16 73.48 µM -0.14630979642191 0.442490042538122 no 1888 0.441838416326964 2679 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1045 1348-1485 165 µM -0.146409542571098 0.44244884300149 no 1889 0.441799047301934 2649 6810614 SGTC_3206 9114350 49.47 µM -0.146539167651624 0.442395303085149 no 1890 0.441747886155486 2750 17087243 SGTC_2031 5180455 200 µM -0.148018825277099 0.441784224959736 no 1891 0.44116395573542 2664 29949 SGTC_54 0159-0055 9 µM -0.149538125723295 0.441156919051206 no 1892 0.44056451379057 2847 3319099 SGTC_2412 st077135 33.4 µM -0.149683925789486 0.441096727212115 no 1893 0.440506995326531 2964 13258915 SGTC_2385 9074692 200 µM -0.15016674132111 0.440897412230518 no 1894 0.440316532447838 2704 17046906 SGTC_98 0074-0023 107.663 µM -0.150537941964301 0.440744184069686 no 1895 0.440170109215245 2742 3563821 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.150936648831409 0.440579611478875 no 1896 0.440012845034332 2783 7104 SGTC_142 0335-0849 62.6745 µM -0.151194339937102 0.440473250841251 no 1897 0.439911207522783 2696 3889043 YPR107C YTH1 SGTC_3105 9121040 49.47 µM -0.15209562811112 0.440101282753822 no 1898 0.439555756177328 2635 41448907 SGTC_3174 9107204 49.47 µM -0.154592931736006 0.439070904793246 no 1899 0.438571121331332 2792 3938802 SGTC_1431 4049-0260 9.09 µM -0.155066262751866 0.438875656533593 no 1900 0.438384539424493 2644 3854841 SGTC_1464 k208-0027 110 µM -0.156524791134086 0.438274109718834 no 1901 0.437809689787229 2854 X1464 SGTC_2424 5537928 59.2 µM -0.157230080604059 0.437983275363308 no 1902 0.437531761117826 2707 5382802 SGTC_1828 st055811 49 µM -0.157330678084995 0.437941795542246 no 1903 0.437492121854528 2803 5877589 SGTC_1217 1183-1422 255 µM -0.160848402631125 0.43649174804003 no 1904 0.436106400873459 2816 2849664 SGTC_1547 harmine 94.2 µM -0.161201927434637 0.436346067800207 no 1905 0.43596718154972 2714 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.161212429334942 0.436341740316844 no 1906 0.435963045985323 2724 115019 SGTC_2936 9038235 15.59 µM -0.161634454620117 0.436167844062906 no 1907 0.435796861600234 2679 4749415 SGTC_3117 9124945 49.47 µM -0.161744809879503 0.436122374019627 no 1908 0.435753407965988 2662 17592065 SGTC_1660 st012960 28.1 µM -0.164652782696859 0.434924498364733 no 1909 0.434608641779324 2780 24207266 SGTC_1961 st076550 68.7 µM -0.167961453339266 0.433562290687932 no 1910 0.433306801992484 2821 1579337 SGTC_3219 9131112 49.47 µM -0.168755800411603 0.433235368095086 no 1911 0.432994362879364 2739 17612988 YMR079W SEC14 SGTC_3003 9075612 71.4286 µM -0.171059343872692 0.432287577624452 no 1912 0.432088551755133 2793 6501993 SGTC_1260 0700-1617 7.75 µM -0.171337614105664 0.432173109899689 no 1913 0.431979152978582 2806 2853078 SGTC_227 fluconazole 33.516 µM -0.172562011758206 0.431669516127231 no 1914 0.43149785704525 2712 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2781 5567276 71.43 µM -0.172994670757814 0.431491590334956 no 1915 0.43132780829373 2867 2853274 SGTC_3010 9080089 71.4286 µM -0.174627851812551 0.430820089885405 no 1916 0.430686031133473 2822 17027233 SGTC_1409 3909-8004 61.9 µM -0.174733000094012 0.430776863837417 no 1917 0.430644718167405 2755 2119279 SGTC_3202 9113761 49.47 µM -0.174947803236873 0.430688561682112 no 1918 0.430560323950768 2910 4798415 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.175336029836251 0.430528976696493 no 1919 0.430407801271209 2733 641818 YHR062C RPP1 SGTC_2066 5222451 176 µM -0.176103552823201 0.430213511000837 no 1920 0.430106294899318 2715 2281147 SGTC_990 3985-0011 41.3 µM -0.176565490210496 0.430023667917423 no 1921 0.42992485147688 2793 5399565 YGL099W LSG1 SGTC_2421 5690543 90.72 µM -0.177493099562982 0.429642495845657 no 1922 0.429560542467552 2804 3397993 SGTC_1055 3448-0672 86 µM -0.177976645854985 0.429443823589715 no 1923 0.429370658408815 2869 748378 SGTC_1784 st039334 36.3 µM -0.178575340641143 0.429197865609366 no 1924 0.429135579270383 2966 3496984 SGTC_857 0438-0306 1.35 µM -0.179592105039004 0.428780217770516 no 1925 0.428736401586585 2808 4686136 SGTC_334 1502-1024 68.5 µM -0.179664446304567 0.428750505784559 no 1926 0.428708003464225 2835 3296216 SGTC_1563 conessine 56.1 µM -0.179668242887025 0.42874894646434 no 1927 0.428706513096659 2831 441082 An anti-amoebic, histamine inhibitor. SGTC_2697 mebhydrolin 72.4 µM -0.179961684033926 0.428628428620682 no 1928 0.428591324373951 2840 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_345 1362-0200 395 µM -0.180240644672091 0.428513864169465 no 1929 0.42848182553577 2740 1419823 SGTC_1282 0886-0010 32.4 µM -0.181241463833247 0.428102894180696 no 1930 0.428089025028899 2855 2836211 YNL267W PIK1 SGTC_1514 1189-1591 158 µM -0.181334827612555 0.428064559844003 no 1931 0.428052385333049 2935 767698 YMR146C TIF34 SGTC_2128 5255449 168.493 µM -0.18162511020844 0.427945376732503 no 1932 0.427938470750586 2743 736008 SGTC_718 1130-0073 349 µM -0.181866783868726 0.427846156304791 no 1933 0.427843636183482 2871 6740020 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.182067253407527 0.427763855913539 no 1934 0.427764973586931 3141 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_453 enantio-paf c16 10 µM -0.182299594949941 0.427668474781483 no 1935 0.42767380827079 2835 13871343 A lipid and platelet activating factor SGTC_2865 9030313 51.95 µM -0.182479716843225 0.427594533831606 no 1936 0.427603135364489 2716 42562754 SGTC_1569 carminic acid 40.6 µM -0.183759303736991 0.427069330277698 no 1937 0.427101141654901 2824 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_975 1335-0046 28.5 µM -0.184229631905085 0.426876317577739 no 1938 0.426916657208821 2780 16486740 SGTC_2307 7538926 6.34 µM -0.184959203886294 0.42657695137484 no 1939 0.426630517000125 2796 96582 SGTC_2036 5160441 105 µM -0.185446307715894 0.426377100972988 no 1940 0.426439494976241 2781 134534 YIL048W NEO1 SGTC_2488 5268135 45.7 µM -0.188035233169354 0.42531522740433 no 1941 0.425424515850633 2867 1270356 YLR208W SEC13 SGTC_277 nystatin 15.5 µM -0.188898482242448 0.424961277206107 no 1942 0.425086191578305 2697 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3054 9094397 49.47 µM -0.189675384762486 0.424642782606063 no 1943 0.424781755373671 2776 2598354 SGTC_1281 0884-0031 11.8 µM -0.189861313391281 0.424566567635493 no 1944 0.424708904222374 2737 1548255 SGTC_603 3794-0023 45.9 µM -0.191116059528721 0.424052301999872 no 1945 0.424217332927914 2823 3802260 SGTC_2453 5731132 22.18 µM -0.191447486938392 0.423916485932171 no 1946 0.424087509417704 2872 1362040 SGTC_951 1171-0579 82.7 µM -0.191563109694051 0.423869106858625 no 1947 0.424042220737699 2698 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1460 k062-0059 9.15 µM -0.192726794673419 0.423392321658025 no 1948 0.423586468863217 2655 1373085 SGTC_3036 9090181 49.47 µM -0.19352964069416 0.423063444791603 no 1949 0.42327209745134 2726 25236586 SGTC_1138 3761-0006 1.03 µM -0.194312467664585 0.422742820119501 no 1950 0.422965611952146 2720 12061087 SGTC_211 3455-0679 143.504 µM -0.19727275548123 0.421530830974078 no 1951 0.42180704918714 2807 748649 SGTC_2149 5554786 194.827 µM -0.198359319273254 0.421086160191877 no 1952 0.421381971758018 2782 745063 YPR165W RHO1 SGTC_848 0368-0089 85.6 µM -0.198839237498935 0.420889788075541 no 1953 0.421194250846412 2867 762535 SGTC_441 propafenone 146 µM -0.200280422709443 0.420300204868332 no 1954 0.420630636385563 2737 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_788 1182-0090 188 µM -0.20082683177586 0.420076717735126 no 1955 0.420416990804827 2965 5715185 SGTC_2040 5100729 123 µM -0.201820763042394 0.419670255367474 no 1956 0.420028424490881 2756 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_77 0828-0286 12.516 µM -0.202216933531721 0.419508267626333 no 1957 0.419873567771208 2725 745345 SGTC_2717 st081029 62.2815 µM -0.202432191488815 0.419420257827021 no 1958 0.419789432072178 2850 5292846 SGTC_3258 9138477 49.47 µM -0.20251824771787 0.419385074232351 no 1959 0.419755797170508 2784 4970355 SGTC_1257 0669-0121 16 µM -0.203072460130202 0.419158503126099 no 1960 0.419539198433024 2871 4307855 SGTC_2085 5307070 144.047 µM -0.203189604564921 0.419110615992864 no 1961 0.419493418858693 2744 2840351 SGTC_605 1315-0399 119 µM -0.203523450795547 0.418974150537742 no 1962 0.41936295907305 2876 24020461 SGTC_670 4204-0025 119 µM -0.20485032096788 0.418431865791179 no 1963 0.418844535068836 2883 719039 SGTC_3304 9125678 46.087 µM -0.206478468044357 0.417766662657919 no 1964 0.418208591186753 2800 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1313 1220-0047 237 µM -0.207169720855837 0.417484312305089 no 1965 0.41793865678722 2822 3528706 SGTC_1480 1070-0044 41.2 µM -0.207746344098654 0.417248816286219 no 1966 0.417713514828605 2860 3124987 SGTC_1883 5-benzylidenerhodanine 20 µM -0.207844867840779 0.417208581629377 no 1967 0.417675049029351 2881 1273210 SGTC_2688 kanamycin b 96.69 µM -0.207919146941471 0.417178248456976 no 1968 0.417646049383106 2893 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3018 9082602 49.47 µM -0.209364358106299 0.416588169467427 no 1969 0.417081907143373 2761 17332089 SGTC_1721 st082152 9.2685 µM -0.209798194989138 0.416411070697148 no 1970 0.416912590952122 2745 5296051 SGTC_1590 st077108 57.8 µM -0.210275883654053 0.416216090594601 no 1971 0.416726178282426 2848 5489485 SGTC_1324 1418-0026 34.4 µM -0.21089806490124 0.415962163295681 no 1972 0.416483407076844 2878 1372513 SGTC_2177 5811945 192 µM -0.211028371349633 0.415908986504202 no 1973 0.416432566352276 2943 5343475 SGTC_944 3370-0224 231 µM -0.211064365764331 0.415894297805745 no 1974 0.416418522918199 2817 4580514 SGTC_2926 9010726 65.15 µM -0.211098082118874 0.415880538850835 no 1975 0.416405368379559 2892 2994293 SGTC_3299 9121982 43.1275 µM -0.21230864337212 0.415386601992601 no 1976 0.415933126350176 2812 17594604 YPL160W CDC60 SGTC_71 0417-1750 47.813 µM -0.213565339066425 0.414873982646614 no 1977 0.415443015586791 3000 6811472 SGTC_247 mechlorethamine 29.705 µM -0.214425512768589 0.414523192262598 no 1978 0.415107624000213 2775 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1915 st067105 30.6 µM -0.214975390598864 0.414298980396968 no 1979 0.414893252725662 2745 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3056 9094900 49.47 µM -0.215192115986124 0.414210618611423 no 1980 0.414808768738946 2823 25236784 SGTC_2101 5377231 179.231 µM -0.215522054384201 0.414076106733629 no 1981 0.41468015957225 2916 2844213 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.215542813334395 0.414067643898614 no 1982 0.414672068090763 2724 4000243 SGTC_422 cantharidin 155 µM -0.216145970660543 0.413821771207992 no 1983 0.414436983568195 2758 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2208 7283366 200 µM -0.21700500125934 0.413471651978341 no 1984 0.414102223684513 2872 898663 SGTC_2272 7805186 180 µM -0.217950530351546 0.413086357678847 no 1985 0.413733827923165 2911 2956062 YPR165W RHO1 SGTC_1417 3966-0327 90.4 µM -0.218064789006421 0.413039804002067 no 1986 0.413689315755736 2836 651118 SGTC_3336 9143619 71.43 µM -0.218132372893785 0.413012268121372 no 1987 0.413662987372358 2799 45595730 SGTC_3267 9137951 49.47 µM -0.218798788602864 0.412740771555384 no 1988 0.413403395284071 2748 16643986 SGTC_1120 ficusin 1.78878 µM -0.218890258476849 0.412703510147241 no 1989 0.413367767539518 2928 6199 A DNA cross-linker. SGTC_2540 epiandrosterone 100 µM -0.219136619324591 0.412603155858515 no 1990 0.413271812922234 2818 441302 A steroid. SGTC_1183 1254-0324 198 µM -0.219741138486532 0.412356931167204 no 1991 0.413036381867379 2930 5799357 SGTC_2465 5809242 33.21 µM -0.220369673095708 0.412100961397508 no 1992 0.412791631115571 2779 2731748 SGTC_1508 1080-0625 72.9 µM -0.220381116748025 0.41209630133365 no 1993 0.412787175282666 2767 767111 SGTC_601 0986-0029 62.9 µM -0.220947682336504 0.411865601007474 no 1994 0.412566584809991 2822 24747981 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.221463312080027 0.411655667764247 no 1995 0.412365850041511 2816 6708514 SGTC_1611 st001856 99.4 µM -0.224095791373613 0.410584276756092 no 1996 0.411341383604956 2836 647478 SGTC_1707 st032323 6.317 µM -0.224243946219672 0.410523999060962 no 1997 0.411283744952925 2815 3132057 YMR211W DML1 SGTC_1524 corynanthine 62.1 µM -0.22529368555316 0.410096966881775 no 1998 0.410875405806067 2991 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_714 4296-0578 26.1 µM -0.225724631936925 0.409921689457176 no 1999 0.410707799476732 2820 1589775 SGTC_1332 1480-0653 17.5 µM -0.225755569591173 0.409909106977428 no 2000 0.410695767640016 2888 5749438 SGTC_2852 9023854 51.95 µM -0.225841851855046 0.409874016092247 no 2001 0.41066221240131 2961 19798528 SGTC_3129 9127257 49.47 µM -0.225920017893473 0.409842226688623 no 2002 0.410631814133398 2838 837894 SGTC_1495 4469-0029 237 µM -0.226858357529106 0.409460658966899 no 2003 0.410266941855712 2787 793680 SGTC_2897 9048598 12.99 µM -0.226878211433742 0.409452586472892 no 2004 0.410259222525868 2822 6467404 SGTC_1830 st055982 50.3 µM -0.227239582074153 0.409305661768614 no 2005 0.410118725302411 2806 455313 An antimicrobial agent. SGTC_2971 9092186 9.93 µM -0.22833581352189 0.408860038161961 no 2006 0.409692592337469 2772 25236400 SGTC_1038 k292-0204 154 µM -0.229392123445578 0.408430754275203 no 2007 0.409282078772125 2779 4454212 SGTC_2436 5633522 8.09 µM -0.22961920891726 0.408338481169704 no 2008 0.409193839554082 2948 5724242 SGTC_1810 st050138 53 µM -0.22983923506468 0.40824908137248 no 2009 0.409108347785419 2875 3444541 SGTC_169 k015-0017 16.025 µM -0.230402362620336 0.408020296286644 no 2010 0.408889562715952 3005 1840002 SGTC_2112 5488546 200 µM -0.232310895562386 0.407245139246774 no 2011 0.408148275236914 2813 600757 SGTC_1091 telmisartan 47.6 µM -0.232878408688189 0.407014711796393 no 2012 0.407927912455147 2917 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1741 st038134 10.228 µM -0.232973412411287 0.406976140561154 no 2013 0.407891025782613 3040 1272587 SGTC_3115 9123671 49.47 µM -0.23323665813863 0.406869268276199 no 2014 0.407788820802487 2786 3286988 SGTC_1779 st039427 55 µM -0.234845692825576 0.406216184709783 no 2015 0.407164250789496 2984 1124498 SGTC_1668 st014914 51.6 µM -0.23593409715767 0.405774565147657 no 2016 0.406741904653218 2845 2839556 SGTC_377 3970-0964 33.1 µM -0.238102569112114 0.40489506653922 no 2017 0.405900771086083 2810 16481235 SGTC_1250 0485-0349 40.2 µM -0.238581954485526 0.40470069992001 no 2018 0.405714879663776 2863 6842794 YDL195W SEC31 SGTC_1775 st081588 35.1725 µM -0.239520483994973 0.404320241601045 no 2019 0.405351007361481 2844 1426443 YGL099W LSG1 SGTC_1141 3253-0389 52.6 µM -0.240215211933205 0.404038673089801 no 2020 0.405081710736078 2897 5402031 SGTC_3139 9095020 49.47 µM -0.241720702542427 0.403428678741864 no 2021 0.404498293436579 2769 25236292 SGTC_1678 st019265 80.2 µM -0.242492000525743 0.403116255291009 no 2022 0.404199477290259 3066 5367020 SGTC_2784 7567673 72.73 µM -0.244513587674828 0.402297681216739 no 2023 0.40341653992423 2786 3471247 SGTC_202 3594-0513 34.79 µM -0.244601885300049 0.402261937783307 no 2024 0.403382352070187 2811 708429 SGTC_182 3448-4371 550.524 µM -0.245159015392617 0.402036426879279 no 2025 0.403166654560259 2818 3491403 SGTC_765 1319-0117 244 µM -0.245259977362104 0.401995563744918 no 2026 0.403127569452292 2824 3487746 YGL099W LSG1 SGTC_913 3487-1245 167 µM -0.247078293237957 0.401259806212768 no 2027 0.402423816253685 2811 4016153 SGTC_2841 9004761 38.96 µM -0.247593359549509 0.401051454923383 no 2028 0.402224524549104 2863 2991039 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.248862720145939 0.40053810163265 no 2029 0.401733486602465 2951 756377 SGTC_1093 fluphenazine 7.97 µM -0.25049237803755 0.399879289245351 no 2030 0.401103299153543 2857 6602611 An atypical antipsychotic. SGTC_2237 6667747 47.222 µM -0.250900229071585 0.399714454160841 no 2031 0.400945623651424 2858 729940 YDL015C TSC13 SGTC_2430 5571206 200 µM -0.250974150852826 0.399684580206527 no 2032 0.400917047164223 3013 1731771 SGTC_378 3970-0959 8.33 µM -0.251533693386435 0.399458471756976 no 2033 0.400700757892321 2974 6615653 SGTC_636 0kpi-0074 126 µM -0.253224780363768 0.398775316875876 no 2034 0.400047259221814 2942 616434 SGTC_1768 st044301 37.178 µM -0.253757252173315 0.398560276274289 no 2035 0.399841550218584 2903 3931349 SGTC_2621 lithochol-11-enic acid 100 µM -0.254892072187538 0.398102078076285 no 2036 0.399403229779368 2916 6708711 SGTC_1107 amlodipine 47 µM -0.255637559871682 0.39780115423688 no 2037 0.39911535661092 2917 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_59 0330-0160 1.33 µM -0.255795241914824 0.397737512027501 no 2038 0.399054474057943 2883 4293482 SGTC_575 k072-0246 11.9 µM -0.25623560450372 0.397559791254244 no 2039 0.398884458837678 2839 6796779 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.256869092843111 0.397304166424343 no 2040 0.398639915268443 2837 1241132 A phosphatase inhibitor. SGTC_2287 7945887 168.79 µM -0.258752534551592 0.39654442205999 no 2041 0.39791309138351 2967 1245853 SGTC_3143 9086658 49.47 µM -0.259185351202902 0.396369887476002 no 2042 0.397746116533377 2921 25236626 SGTC_2107 5363541 170.161 µM -0.259586793486527 0.396208023259275 no 2043 0.397591262234985 2917 244052 SGTC_2649 anisomycin 9.56 µM -0.259793352863469 0.396124744104832 no 2044 0.397511589302642 2917 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2162 5663267 200 µM -0.259970106314599 0.396053485657051 no 2045 0.397443416340347 3020 6456493 SGTC_3092 9117248 49.47 µM -0.261807019681504 0.395313137007658 no 2046 0.396735113432155 2870 17141857 SGTC_1309 pyrazolanthrone 13.4 µM -0.262072900115529 0.395206007918228 no 2047 0.396632619673624 2965 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1401 3807-4679 7.6 µM -0.26286847479411 0.39488550067357 no 2048 0.39632597773874 2859 3291456 SGTC_88 0180-0332 8.668 µM -0.263431070644437 0.394658894789436 no 2049 0.396109172578046 2833 3101745 SGTC_2262 9014885 67.46 µM -0.263606811955543 0.394588115903525 no 2050 0.396041454482126 2872 6457424 SGTC_16 erodoxin 22.806 µM -0.263610878564517 0.394586478139396 no 2051 0.396039887539841 2958 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_158 k038-0087 26.446 µM -0.264015384343096 0.394423578981986 no 2052 0.395884032117382 2849 X158 SGTC_2274 7947094 46.08 µM -0.264175800087965 0.394358982816391 no 2053 0.395822228797948 2866 2971028 SGTC_90 0870-0863 4.608 µM -0.265227298136449 0.393935637897927 no 2054 0.3954171834188 2838 1738164 SGTC_2789 5281112 71.43 µM -0.265314440020893 0.393900559212763 no 2055 0.395383620736785 2918 765948 SGTC_1177 0983-0204 23.6 µM -0.266633656534219 0.393369618165689 no 2056 0.394875619647884 3025 766818 SGTC_1092 toremifene 6.32 µM -0.266950125884896 0.393242279155893 no 2057 0.394753780842359 2870 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1726 st035556 14.5795 µM -0.267196360379199 0.393143208718976 no 2058 0.394658989155257 3083 5919439 SGTC_295 k015-0027 31 µM -0.267674515147082 0.392950846826014 no 2059 0.394474934074724 2949 3887424 SGTC_2746 daunorubicin 9.88 µM -0.268058561378003 0.392796363768573 no 2060 0.394327121045612 2885 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3124 9127567 49.47 µM -0.268293743493179 0.392701769815013 no 2061 0.394236610858196 3102 17592030 SGTC_903 1134-0042 114 µM -0.268469513957503 0.39263107630172 no 2062 0.394168969061916 2884 701009 SGTC_1187 1391-0724 117 µM -0.270438533881678 0.391839394410965 no 2063 0.393411449183633 2910 6997986 SGTC_1393 3470-5649 58.2 µM -0.270526066711835 0.391804210541187 no 2064 0.393377782960497 2963 4108395 SGTC_226 1,3-diallylurea 8.28947 mM -0.271324052397349 0.391483500588268 no 2065 0.393070904459325 2977 74537 YKL182W FAS1 SGTC_15 0266-0086 27.098 µM -0.272751983217375 0.390909800261912 no 2066 0.392521936134934 2968 1712902 YIL048W NEO1 SGTC_2886 9058944 51.95 µM -0.273360316213905 0.390665462094805 no 2067 0.392288127251128 2923 4949929 SGTC_233 rapamycin 362 pM -0.273975719506853 0.390418328048972 no 2068 0.392051640502787 2917 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1812 st052057 4.327 µM -0.275429325101405 0.389834764131529 no 2069 0.39149320841514 2860 3645418 SGTC_3200 9114385 49.47 µM -0.275611905399619 0.389761483040054 no 2070 0.391423082267645 3028 17018030 YLR208W SEC13 SGTC_216 k038-0035 28.382 µM -0.276422463432313 0.389436201872889 no 2071 0.391111802638224 2986 4444231 YPR107C YTH1 SGTC_885 0865-0106 16.8 µM -0.276530144054357 0.389392994900543 no 2072 0.391070455155772 2894 2793380 SGTC_1246 0422-0085 105 µM -0.277886323236959 0.388848943677836 no 2073 0.390549811526924 3039 264295 SGTC_1271 0832-2808 169 µM -0.27801766826066 0.388796264247286 no 2074 0.390499397954156 3049 3663794 SGTC_2232 chlorophetanol 41.5365 µM -0.278151927674295 0.38874241803608 no 2075 0.390447867666749 2943 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1400 3771-8998 51.5 µM -0.278989195803225 0.388406670730712 no 2076 0.390126558104981 2896 670767 SGTC_1899 st063254 59.6 µM -0.278991936207865 0.388405571956075 no 2077 0.390125506571888 2861 3093813 SGTC_2624 nerol 100 µM -0.279113455314358 0.388356849351587 no 2078 0.390078878732794 2881 637566 A natural product oil. SGTC_847 0342-0274 5.54 µM -0.279148238424757 0.388342903524586 no 2079 0.390065532470235 3026 18097 SGTC_1855 st056195 39.6 µM -0.282452769020322 0.387018654681225 no 2080 0.388798178776427 3083 4028379 SGTC_2843 9000894 45.46 µM -0.282490816011528 0.387003415453146 no 2081 0.388783593853536 2931 2242070 SGTC_481 bay k-8644 50 µM -0.283981066977165 0.386406652035089 no 2082 0.388212444979674 2908 2303 A calcium channel antagonist. SGTC_1385 3091-4834 14.1 µM -0.285734553441371 0.385704821306141 no 2083 0.38754071884934 3017 4072814 SGTC_2747 doxorubicin 7.63 µM -0.286170886906436 0.385530237415383 no 2084 0.387373620299098 2940 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1435 4092-0789 56.7 µM -0.287404712847124 0.385036689836977 no 2085 0.386901226513588 3008 2248285 SGTC_314 1671-0008 2.74 µM -0.287453106809219 0.385017335366957 no 2086 0.386882701371645 2898 3913060 SGTC_2759 disulfiram 3.38 µM -0.288722232451847 0.384509869196277 no 2087 0.386396973940874 2920 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1764 st044502 93.5 µM -0.291554346736114 0.383378148815167 no 2088 0.385313692748052 3053 8407 SGTC_2492 derrusnin 100 µM -0.291622961491761 0.383350742476009 no 2089 0.385287458726432 2856 1715307 Part of coumarin class of compounds. SGTC_1215 3852-0577 11.2 µM -0.29314861927846 0.382741510072352 no 2090 0.384704277736237 3070 2884876 SGTC_1403 3909-7815 62.9 µM -0.293705875663675 0.382519056225963 no 2091 0.384491332055999 2901 6615483 SGTC_1643 st009866 20.2 µM -0.294132256541929 0.382348873370474 no 2092 0.38432842166871 3013 3156273 YOR207C RET1 SGTC_901 1112-0062 60.1 µM -0.29532068895763 0.381874650308592 no 2093 0.383874456721549 2938 1908457 SGTC_2478 5763493 32.33 µM -0.295511782643969 0.38179841425157 no 2094 0.383801476395299 2921 1365576 YLR208W SEC13 SGTC_652 0437-0092 114 µM -0.296939541046824 0.38122896104595 no 2095 0.383256333741309 2943 3091274 SGTC_3280 9140961 49.47 µM -0.29708880534623 0.381169442662417 no 2096 0.383199355394648 2899 4901226 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.29905744865607 0.38038471961515 no 2097 0.382448106184535 3004 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_303 1348-1668 34.2 µM -0.30046614496786 0.379823499436232 no 2098 0.381910808236754 2961 5380509 SGTC_881 0833-0569 170 µM -0.300694550389768 0.379732527242321 no 2099 0.38182371237178 2949 5418700 SGTC_2760 etidronate 98.04 µM -0.302778882776821 0.378902661137689 no 2100 0.381029188792167 2964 3305 A chelator and antioxidant. SGTC_2452 5863136 48.41 µM -0.303048603324151 0.378795313993657 no 2101 0.380926410978507 2895 2184096 SGTC_341 1486-1430 230 µM -0.303114902942282 0.378768928578469 no 2102 0.380901148598585 2907 2054753 YPL210C SRP72 SGTC_599 1935-0052 86.5 µM -0.303117682102165 0.378767822562003 no 2103 0.380900089656469 2940 9557311 SGTC_332 4112-0506 40.9 µM -0.30323235951406 0.378722185497188 no 2104 0.380856394948644 2934 2790355 SGTC_2484 5809818 12.04 µM -0.303802156244819 0.378495454068462 no 2105 0.380639311947074 2964 2870548 SGTC_1934 st074720 32.6 µM -0.304265039769363 0.378311295934525 no 2106 0.380462988742614 2925 17250992 SGTC_1641 st009299 47.1 µM -0.30519423735734 0.377941698294686 no 2107 0.380109110550822 2983 4046054 SGTC_1329 1447-1697 50.6 µM -0.306638232525569 0.377367556530014 no 2108 0.379559374645926 3030 2840515 SGTC_2013 4024628 200 µM -0.30774966239364 0.376925829312633 no 2109 0.379136413638291 3098 5230760 SGTC_10 0279-0212 42.575 µM -0.30801872527483 0.376818917023156 no 2110 0.379034041945478 2959 39851 YBR002C RER2 SGTC_1706 st031321 9.9705 µM -0.308093472002615 0.376789218044293 no 2111 0.37900560419165 3061 6103185 SGTC_796 1234-0020 70.7 µM -0.310507448174423 0.37583047027862 no 2112 0.378087548191878 2943 46495034 SGTC_3038 9091290 49.47 µM -0.310647176434028 0.375774998449275 no 2113 0.378034429341327 3108 25236843 SGTC_3114 9122766 49.47 µM -0.310921161435046 0.375666234425655 no 2114 0.377930278376841 3011 17176985 SGTC_2133 5320837 200 µM -0.311238562934055 0.375540247675567 no 2115 0.377809634425904 3106 2841355 SGTC_1977 st070720 65.3 µM -0.312852643353721 0.374899773419853 no 2116 0.377196308911566 3057 682188 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.313914334385283 0.37447867762177 no 2117 0.376793051519672 3088 16725076 SGTC_1787 fluconazole 80 µM -0.314950655848982 0.374067788425086 no 2118 0.376399559732146 3046 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1730 st033808 45.1 µM -0.315683543957289 0.373777293277825 no 2119 0.376121359239266 2949 1045166 SGTC_2059 5238311 157 µM -0.315917743394018 0.373684478661731 no 2120 0.376032471920389 2937 703021 SGTC_1245 0418-0076 17.2 µM -0.316439804803733 0.373477609021966 no 2121 0.375834354047323 3133 6790114 SGTC_1499 4480-0877 67.3 µM -0.318537193690449 0.372646875388266 no 2122 0.375038743112357 2963 2861909 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.319585931874144 0.372231713026373 no 2123 0.374641120129972 2968 390807 SGTC_1946 st076057 65.1 µM -0.319644452598648 0.37220855088663 no 2124 0.374618936259097 2940 953009 SGTC_1669 st015249 58.4 µM -0.320154320157382 0.372006768039586 no 2125 0.37442567467068 3067 722793 SGTC_2466 5983409 37.09 µM -0.320216554606231 0.371982140825243 no 2126 0.374402087314912 2993 2879657 SGTC_2874 9043904 71.43 µM -0.321198387407496 0.371593682499747 no 2127 0.374030027058722 3024 4463428 SGTC_860 0443-0016 25.1 µM -0.322363796367648 0.371132762674328 no 2128 0.373588553899504 2962 5337942 SGTC_1254 0550-0035 264 µM -0.322723426555034 0.370990566035511 no 2129 0.373452354427441 3114 15121435 SGTC_669 0108-0021 26.2 µM -0.323122209380173 0.370832909162868 no 2130 0.373301345514905 3235 17201 SGTC_1348 1493-0373 93.8 µM -0.323412077452109 0.370718324821051 no 2131 0.373191592059502 3030 3010129 SGTC_2849 9019321 12.99 µM -0.324069603281689 0.370458448526528 no 2132 0.372942669601923 3108 16489627 SGTC_1071 trifluoperazine 6.31 µM -0.324529646432164 0.370276659156548 no 2133 0.372768540563233 3126 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2673 kobusone 100 µM -0.324561030523306 0.37026425856167 no 2134 0.372756662446926 2992 6710676 An epoxy ketone and protein crosslinker. SGTC_2603 homopterocarpin 100 µM -0.325198146788401 0.370012548062954 no 2135 0.372515555587146 3086 101795 A weak amylase inhibitor. SGTC_551 k048-0028 34.9 µM -0.325882955214458 0.369742057527482 no 2136 0.372256456062402 3129 6836383 SGTC_3126 9127922 49.47 µM -0.326860013109822 0.369356243789852 no 2137 0.371886883106063 3203 45595682 SGTC_2207 7258803 200 µM -0.327037044011688 0.369286353139146 no 2138 0.371819933639822 3058 3666799 SGTC_309 k408-0051 1.48 µM -0.327885727546384 0.36895135842628 no 2139 0.37149903274821 3031 3640463 SGTC_3169 9102970 49.47 µM -0.329780522676102 0.368203799136731 no 2140 0.370782902743002 3013 17027839 SGTC_2419 paclitaxel 166.5 µM -0.330126149649717 0.368067491577259 no 2141 0.370652322628468 2893 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2263 7948595 193.29 µM -0.332568641901404 0.367104701496683 no 2142 0.369729958656858 2958 2971371 SGTC_1440 4100-1550 40 µM -0.333468176630912 0.366750329865356 no 2143 0.36939045372667 3028 742806 SGTC_2158 5657123 3.6195 µM -0.334022855288579 0.366531870825269 no 2144 0.369181156082933 2978 2858827 SGTC_2724 maprotiline 69.64 µM -0.33572919059977 0.365860105548381 no 2145 0.36853754564011 3116 4011 A tricyclic antidepressant. SGTC_1744 st037937 38.9 µM -0.336725118568463 0.365468209600497 no 2146 0.368162063084092 3192 1016152 SGTC_1969 st069479 40.1 µM -0.337683529042897 0.365091209282227 no 2147 0.367800844160429 3172 3895485 SGTC_2628 lathosterol 100 µM -0.337941122990356 0.364989904346136 no 2148 0.367703778527425 3178 6710616 SGTC_1164 k060-0068 93.7 µM -0.338468520635684 0.364782522103034 no 2149 0.367505072791776 3005 5963676 SGTC_1222 0366-0074 1.18 µM -0.338631786299361 0.364718331121913 no 2150 0.367443566955127 3116 286520 SGTC_190 3970-0790 3.722 µM -0.339357909693758 0.364432887949866 no 2151 0.367170061201413 3088 2832352 SGTC_1880 MG-132 525 µM -0.340236430488396 0.364087636995105 no 2152 0.366839242677827 3125 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3085 9117376 49.47 µM -0.340311971651227 0.364057955126791 no 2153 0.366810801275517 3075 16480349 SGTC_2053 5265679 138 µM -0.340722254202937 0.363896759879076 no 2154 0.366656341828759 2983 764595 SGTC_1339 1486-1321 22.7 µM -0.340977155477481 0.363796624256808 no 2155 0.366560389785689 3025 3469382 SGTC_1911 st060208 74.3 µM -0.340989330640215 0.363791841588766 no 2156 0.366555806919005 3107 688783 SGTC_116 0155-0182 31.788 µM -0.341258974702434 0.363685924992449 no 2157 0.366454314772458 3028 771486 SGTC_1014 4130-3005 69.3 µM -0.342770178654714 0.363092514779878 no 2158 0.365885681150298 3003 743608 SGTC_395 anisomycin 6.25 µM -0.343502584443055 0.362805036306513 no 2159 0.365610198438391 3061 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.344278445536255 0.362500585403528 no 2160 0.365318446299589 3091 279621 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.344649388584531 0.362355056616148 no 2161 0.36517898567383 3024 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1108 betulinic acid 729.144 nM -0.345753490403562 0.361922011944803 no 2162 0.364763990514827 3048 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_140 0062-0056 502.533 µM -0.346546018052056 0.361611280077374 no 2163 0.364466203352659 2969 3758964 SGTC_1723 st034307 2.5525 µM -0.346818003269498 0.361504661946417 no 2164 0.364364025497486 3086 867466 SGTC_78 0336-0123 156.75 µM -0.349016785782437 0.36064313529853 no 2165 0.363538353897314 2929 6765896 SGTC_420 mitomycin C 81.9 mM -0.349158555264592 0.360587611410822 no 2166 0.363485139300303 3016 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1852 st056254 31.4 µM -0.349405125187661 0.360491049528354 no 2167 0.36339259308178 3017 442583 SGTC_2201 6605497 169.863 µM -0.349420526522553 0.360485018342151 no 2168 0.363386812692717 3050 670741 SGTC_2203 7227154 166.4 µM -0.350434586220624 0.360087987465873 no 2169 0.363006286946914 3055 896304 SGTC_1421 4029-0249 71.4 µM -0.350662977146354 0.359998587250954 no 2170 0.362920601929188 3175 2894095 SGTC_1294 1000-1494 117 µM -0.351132403774933 0.359814861260502 no 2171 0.362744509526078 3059 712797 YDL207W GLE1 SGTC_1179 1021-1431 9.29 µM -0.352746384474414 0.359183422660255 no 2172 0.362139290999541 3106 2840958 SGTC_36 0335-0881 14.2 µM -0.352801690908687 0.359161791895332 no 2173 0.362118558013516 3045 23828853 SGTC_1613 st002381 52.1 µM -0.352858438270609 0.359139598041964 no 2174 0.36209728528058 3076 551167 SGTC_734 2023-0417 80 µM -0.353542245559298 0.358872198887758 no 2175 0.361840981766209 3125 3935732 SGTC_38 0929-0051 58.268 µM -0.353906677700556 0.358729717899996 no 2176 0.36170441121643 3157 1379719 SGTC_3329 9141233 27.5565 µM -0.354378111202766 0.358545432061315 no 2177 0.361527768154276 3167 4909101 YNL103W MET4 SGTC_1248 0469-0687 58.6 µM -0.356021115562465 0.357903430650165 no 2178 0.360912375973203 3131 4017482 SGTC_2024 5144227 134 µM -0.356679084270267 0.357646442936301 no 2179 0.360666032664258 3173 3475211 SGTC_2350 9023895 38.85 µM -0.358880634694649 0.356787036790053 no 2180 0.359842193595228 3189 2997209 SGTC_3263 9137018 49.47 µM -0.359814263858951 0.356422800609741 no 2181 0.359493017816445 3088 43844957 SGTC_472 calcifediol 10 µM -0.360125568499242 0.356301380608484 no 2182 0.35937661644976 3087 5283731 A vitamin D metabolite. SGTC_1465 k213-0056 144 µM -0.360727976568434 0.356066461181909 no 2183 0.359151404311228 3024 24048857 YMR208W ERG12 SGTC_1143 3454-2408 5.08 µM -0.36089536503912 0.356001194852936 no 2184 0.359088834293226 3068 X1143 SGTC_638 3970-0837 4.09 µM -0.360924312286349 0.355989908478621 no 2185 0.359078014159599 3046 4118451 YLR208W SEC13 SGTC_2726 cimetidine 79.27 µM -0.361217801916348 0.355875485595051 no 2186 0.358968317642662 3022 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1758 st042942 75.2445 µM -0.361552499196694 0.355745012917785 no 2187 0.358843233289906 3097 669317 SGTC_1290 0986-0249 10.2 µM -0.361669046666831 0.355699584006161 no 2188 0.358799680274119 3106 53329 SGTC_2270 7924575 90.91 µM -0.362349637015384 0.355434338380955 no 2189 0.358545384857331 3180 1262135 SGTC_2748 diazoxide 86.69 µM -0.363884142078391 0.3548365546703 no 2190 0.357972263425381 3108 3019 A potassium channel activatior. SGTC_2523 spermine 47.74 µM -0.364649559363533 0.354538511193569 no 2191 0.357686507673299 3146 1103 A DNA binding polyamine. SGTC_945 3381-0768 11.3 µM -0.365743133955378 0.35411284207364 no 2192 0.357278378269846 3194 1126236 YIL048W NEO1 SGTC_263 alizarin 107.927 µM -0.366403606527238 0.353855844250726 no 2193 0.357031964480924 3091 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1906 st060206 94.7 µM -0.367052627153165 0.353603367370896 no 2194 0.356789881347659 3182 5133468 SGTC_1822 st052468 42 µM -0.367205662562759 0.353543844121286 no 2195 0.356732807905848 3111 2873678 SGTC_705 1124-0212 310 µM -0.367721350765784 0.353343293140048 no 2196 0.356540509364363 3211 9554485 SGTC_871 0574-0004 149 µM -0.368096080872198 0.35319758625775 no 2197 0.356400796534493 3032 9551173 SGTC_447 ml7 120 µM -0.371189361822958 0.351995644774134 no 2198 0.355248248036341 3132 4216 Selective myosin light chain kinase inhibitor. SGTC_2402 5553605 200 µM -0.371675775418188 0.351806775468466 no 2199 0.355067131682658 3239 6758546 SGTC_584 0986-0246 15.4 µM -0.37181836001986 0.351751418288811 no 2200 0.355014046436242 3158 53315 YDR232W HEM1 SGTC_819 1013-0258 27.7 µM -0.372139700418183 0.35162667231553 no 2201 0.354894419473653 3076 5753198 SGTC_1978 st071761 42 µM -0.37656902805979 0.349908817785252 no 2202 0.353246954103531 3063 5147680 SGTC_324 1315-0088 19.6 µM -0.377204104803376 0.349662762539083 no 2203 0.35301096501757 3144 6787421 SGTC_841 0251-0215 91.2 µM -0.377545257610166 0.349530611759721 no 2204 0.352884218885183 3125 3888614 SGTC_1084 voriconazole 435 nM -0.378804411888475 0.349043016965094 no 2205 0.352416555453438 3183 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1836 st055642 81 µM -0.380504767465205 0.348384966879029 no 2206 0.351785379147368 3086 8571 SGTC_3090 9117696 49.47 µM -0.380914858909515 0.348226326669736 no 2207 0.351633213205281 3112 7923821 SGTC_100 0086-0128 49.5915 µM -0.382744067972366 0.34751903718837 no 2208 0.350954768198754 3109 93297 SGTC_1389 3405-0187 19 µM -0.38403350947041 0.347020775075171 no 2209 0.350476805648633 3111 799890 SGTC_1264 0783-0040 158 µM -0.384261623207349 0.346932655547788 no 2210 0.350392274411237 3017 2855798 SGTC_608 k048-0125 159 µM -0.384539315000905 0.346825395365191 no 2211 0.350289381222652 3194 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3313 9133968 57.047 µM -0.384885602981109 0.346691656676749 no 2212 0.350161086470724 3127 1494643 SGTC_1065 prochlorperazine maleate 2.48 µM -0.385814677508886 0.346332936420907 no 2213 0.349816962136031 3137 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1134 3477-0009 42.5 µM -0.387376418732166 0.345730251063093 no 2214 0.349238779401738 3303 3973534 SGTC_1189 1431-2119 7.28 µM -0.387552659413718 0.345662263228764 no 2215 0.349173554087365 3129 3107275 SGTC_1423 4048-0112 5.59 µM -0.387663091514785 0.345619664707815 no 2216 0.349132686290266 3169 X1423 SGTC_268 camptothecin 39.6153 µM -0.387790031507213 0.345570700781679 no 2217 0.349085711550887 3190 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2288 7946289 167.31 µM -0.387882780618956 0.345534926765777 no 2218 0.349051390769155 3276 1246052 SGTC_1234 0326-0494 15.5 µM -0.388560778245302 0.345273460004023 no 2219 0.348800542773049 3220 1547813 SGTC_1861 st057647 17.4 µM -0.388763767504653 0.345195192456974 no 2220 0.348725452926375 3252 688668 SGTC_708 3448-5400 146 µM -0.389066734204435 0.345078388442415 no 2221 0.348613390418109 3184 3462195 SGTC_1000 4048-0884 8.67 µM -0.391330030986318 0.344206277817759 no 2222 0.347776651848673 3213 13040088 SGTC_2910 7948405 25.97 µM -0.3918919329335 0.343989889613014 no 2223 0.347569031900005 3246 2971328 SGTC_460 trequinsin 123 µM -0.392379663407925 0.343802106221908 no 2224 0.347388854996939 3176 5537 A vasodilator. SGTC_3222 9128301 49.47 µM -0.393694994020812 0.343295876800888 no 2225 0.346903118852099 3083 4911358 SGTC_2337 9009472 200 µM -0.3938278392861 0.343244764443241 no 2226 0.346854074625652 3293 5742383 SGTC_2200 6600604 21.907 µM -0.394884786472446 0.342838205111081 no 2227 0.346463959068454 3097 2904777 SGTC_1982 st072467 71.9 µM -0.39525737698079 0.342694929898144 no 2228 0.346326475986964 3043 3163533 SGTC_2946 9065502 71.43 µM -0.396014678493427 0.34240378842654 no 2229 0.346047099863434 3124 16489101 SGTC_2468 5987765 72.9 µM -0.396425537458432 0.342245874540588 no 2230 0.345895564915368 3132 26772094 SGTC_1892 st058411 7.36 µM -0.396881066528977 0.342070823915526 no 2231 0.345727583378401 3218 3934738 SGTC_228 caffeine 993.056 µM -0.397851655208058 0.341697959511045 no 2232 0.345369769057756 3202 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.397932522352273 0.341666900297231 no 2233 0.345339963048604 3109 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2106 5357045 167.29 µM -0.400054164006584 0.340852409976797 no 2234 0.344558311619462 3192 668842 SGTC_19 0279-0214 38.434 µM -0.400091180109734 0.340838206201569 no 2235 0.344544680090256 3125 3566274 YBR002C RER2 SGTC_2071 5230951 39.92 µM -0.400509074670427 0.340677867852516 no 2236 0.344390800484132 3206 1799272 SGTC_1463 k081-0032 34.1 µM -0.402163183423457 0.340043499858177 no 2237 0.343781967702219 3173 977755 SGTC_157 1348-1695 65.819 µM -0.403407329477436 0.339566654948198 no 2238 0.343324297837641 3174 5380510 SGTC_2267 7931562 200 µM -0.403595319606577 0.339494626118375 no 2239 0.343255164002684 3055 934880 SGTC_1041 0206-0046 107 µM -0.403604042286636 0.339491284146706 no 2240 0.343251956342834 3166 50494 SGTC_798 1287-0182 476 µM -0.404711517450848 0.339067073293564 no 2241 0.342844787582075 3286 1649755 SGTC_3353 9151644 39.2805 µM -0.406262055873228 0.338473492814859 no 2242 0.342275031048851 3233 4909158 SGTC_2998 9066762 71.4286 µM -0.407167498514169 0.33812705469664 no 2243 0.341942485475494 3305 4945196 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.407380301607743 0.338045652404168 no 2244 0.341864346205663 3095 6312947 SGTC_2229 7354935 190 µM -0.408194169430933 0.337734398305758 no 2245 0.341565564208046 3190 318112 SGTC_1229 0139-0193 12.2 µM -0.409114938799232 0.337382394741473 no 2246 0.341227656854653 3261 3090752 SGTC_2154 5570129 200 µM -0.411223636511911 0.336576791053922 no 2247 0.340454279012716 3205 673366 SGTC_2857 9024691 58.44 µM -0.412991253737481 0.335902070466612 no 2248 0.339806510885504 3205 16478292 SGTC_1308 1187-1617 41.4 µM -0.414938819858688 0.335159273201618 no 2249 0.339093345365744 3105 2882570 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.414956009319089 0.335152720044353 no 2250 0.33908705343979 3147 689007 SGTC_2555 cholic acid 100 µM -0.415805900568915 0.334828777652144 no 2251 0.338776020390936 3283 6708657 Influences liver metabolism. SGTC_2004 4023728 41.89 µM -0.417780403200057 0.334076655889992 no 2252 0.338053840055246 3282 360084 YDR527W RBA50 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.417910003357052 0.334027312232707 no 2253 0.338006459204491 3238 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2694 st077685 81.9 µM -0.417934607674344 0.334017944767145 no 2254 0.337997464339416 3074 2838096 SGTC_1408 3909-7976 48.8 µM -0.420789538535463 0.332931706207931 no 2255 0.336954385733099 3188 24152374 SGTC_2733 amorolfine 100 µM -0.421145986440063 0.332796183761893 no 2256 0.336824241589523 3204 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_920 mycophenolic acid 780.421 nM -0.421699949195191 0.332585608997618 no 2257 0.336622020772716 3140 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_175 3793-3120 23.7 µM -0.423774039810892 0.331797666035552 no 2258 0.335865306212358 3134 5322297 SGTC_594 1487-1584 10.8 µM -0.424212991111655 0.331631004502091 no 2259 0.335705243661075 3151 5013332 SGTC_3199 9111318 49.47 µM -0.424853621940319 0.331387828867948 no 2260 0.335471692642248 3210 8548020 SGTC_2585 alliin 100 µM -0.425706173949586 0.331064320777406 no 2261 0.335160981349643 3351 87310 A garlic compound which reacts with lipids. SGTC_129 0088-0017 176.636 µM -0.42730313160776 0.33045868105787 no 2262 0.334579276082887 3270 182446 SGTC_1237 0330-0133 46.1 µM -0.428591387931763 0.329970438345017 no 2263 0.334110306984525 3117 X1237 YHR072W ERG7 SGTC_3317 9138495 8.753 µM -0.42887424462777 0.329863275800163 no 2264 0.334007372167338 3196 17020139 SGTC_1320 1313-0481 95.3 µM -0.429420954833878 0.329656189800737 no 2265 0.33380845340742 3324 6813365 YLR208W SEC13 SGTC_2153 5569715 200 µM -0.430437508178247 0.329271272794244 no 2266 0.333438707893118 3215 2054701 SGTC_2671 danthron 100 µM -0.432162313044864 0.328618590977232 no 2267 0.332811724056291 3222 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_322 k048-0136 19.3 µM -0.432175059776491 0.328613769440861 no 2268 0.332807092228897 3244 6823282 SGTC_897 1000-0139 31.4 µM -0.432921648711589 0.328331416990801 no 2269 0.33253584595865 3298 6151020 SGTC_6 0844-0013 19.835 µM -0.433022523514647 0.328293274665479 no 2270 0.332499203441864 3288 1584900 SGTC_1901 st060216 58.6 µM -0.433879049572672 0.327969481051223 no 2271 0.332188137042882 3143 688792 SGTC_2367 9070478 135.38 µM -0.434385701231595 0.327778011717956 no 2272 0.332004189669473 3177 572802 SGTC_2269 7935389 174.42 µM -0.435091290338547 0.327511437123268 no 2273 0.331748082564267 3206 97605 SGTC_1330 1469-0054 61.8 µM -0.435804905717437 0.32724191958528 no 2274 0.331489142128186 3293 7102664 SGTC_740 k014-0057 261 µM -0.436049724825615 0.327149477289002 no 2275 0.331400326310916 3243 4012779 SGTC_1376 2910-0861 41.3 µM -0.436694703756529 0.326905987703117 no 2276 0.331166385357176 3224 1112859 SGTC_2366 9070441 60.58 µM -0.437070153026702 0.326764283680633 no 2277 0.331030236109065 3167 6837235 SGTC_1886 st057356 49.9 µM -0.439454906387533 0.325864801657639 no 2278 0.330165974735979 3159 24207747 SGTC_1270 0831-1170 17.3 µM -0.440372353565813 0.325519028058598 no 2279 0.32983372249431 3246 6764716 SGTC_1966 st070145 16.1 µM -0.441970539444373 0.324917051736909 no 2280 0.32925526232214 3118 3748532 SGTC_1540 guanosine 70.6 µM -0.442761493578852 0.324619298052477 no 2281 0.328969129080723 3234 6802 Guanosine is a purine nucleoside SGTC_3081 9117243 49.47 µM -0.445566156923902 0.323564390255285 no 2282 0.327955330786953 3332 45595589 SGTC_271 rotenone 740 µM -0.445962487240935 0.323415434000612 no 2283 0.327812171694912 3309 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2289 7946404 165.07 µM -0.446901468114436 0.323062641660678 no 2284 0.327473101960646 3160 1246120 YPR165W RHO1 SGTC_615 k087-0205 167 µM -0.446954883639507 0.323042577248193 no 2285 0.327453817675851 3203 9642773 SGTC_698 k064-0052 127 µM -0.446991182735595 0.323028942554164 no 2286 0.327440713094896 3306 5088751 SGTC_1987 st072290 61.9 µM -0.450148664702476 0.321843838477906 no 2287 0.326301624447286 3225 54697379 SGTC_2669 eugenol 100 µM -0.45056593935834 0.321687357086862 no 2288 0.326151209880056 3249 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_139 0099-0334 718.624 µM -0.450892047654687 0.321565085837401 no 2289 0.326033677640628 3225 97690 SGTC_2437 5741531 144.16 µM -0.451055452203117 0.321503826101221 no 2290 0.325974791731834 3354 2262990 SGTC_655 k060-0012 42 µM -0.451656017676781 0.321278718132158 no 2291 0.325758403941726 3192 5994525 SGTC_1154 4088-0362 150 µM -0.452425500610637 0.320990391327176 no 2292 0.325481239828294 3210 6618304 SGTC_144 4161-2749 112.381 µM -0.454416752752845 0.320244766395106 no 2293 0.324764448392668 3221 797501 YMR168C CEP3 SGTC_397 arbidol 50 µM -0.455001878429357 0.320025803645662 no 2294 0.324553943724291 3333 131410 A RNA synthesis inhibitor. SGTC_2923 7992654 58.14 µM -0.455810504740023 0.319723306797194 no 2295 0.32426312476494 3224 2985126 SGTC_560 2332-1943 155 µM -0.456571796802434 0.319438626635369 no 2296 0.323989427304727 3264 21177716 SGTC_24 0417-1663 219 µM -0.457056994243833 0.319257245741307 no 2297 0.323815040182759 3286 4329390 SGTC_1898 st060199 18.6 µM -0.457989234135605 0.318908868808453 no 2298 0.323480087956215 3197 688866 SGTC_2216 7189485 200 µM -0.458936497339135 0.318555041490012 no 2299 0.323139884334332 3295 731273 SGTC_898 1000-0849 28.3 µM -0.45913601535182 0.318480537426214 no 2300 0.323068247538905 3281 6751807 SGTC_1303 1160-0052 261 µM -0.459263471719362 0.318432946480904 no 2301 0.323022487858875 3277 3562476 SGTC_1671 st016596 74.5 µM -0.459819797758897 0.318225254933076 no 2302 0.32282278576529 3287 2829167 SGTC_892 0929-0076 29 µM -0.46027453350928 0.318055532218799 no 2303 0.322659589061567 3240 5751038 SGTC_2339 9000433 200 µM -0.460276685860226 0.318054728979667 no 2304 0.322658816701665 3220 2988954 SGTC_1698 5-fluorocytosine 1.055 µM -0.460480591680906 0.317978636936935 no 2305 0.322585649632583 3320 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1545 lovastatin 49.4 µM -0.460532403528352 0.317959303404984 no 2306 0.32256705919783 3282 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1153 4055-0057 267 µM -0.463515641303414 0.31684694972977 no 2307 0.321497402997343 3213 882706 SGTC_1561 5-methoxyflavone 52.9 µM -0.463893808407852 0.316706061241193 no 2308 0.321361914519903 3274 94525 SGTC_2254 7938975 95.19 µM -0.464697551050242 0.316406710270475 no 2309 0.32107403118009 3400 2969277 SGTC_2316 5844804 197.44 µM -0.465018936334257 0.316287045155734 no 2310 0.320958947958208 3294 776813 SGTC_604 1000-0114 314 µM -0.466628360790183 0.31568807903342 no 2311 0.320382896231611 3344 1572745 SGTC_512 prima-1 270 µM -0.46830811500254 0.315063454765826 no 2312 0.319782133025113 3361 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3340 9146634 11.102 µM -0.469062688895808 0.314783034926495 no 2313 0.319512413761025 3309 4907387 SGTC_2319 6033012 152.6 µM -0.469085776757249 0.314774456542299 no 2314 0.319504162606364 3184 847246 SGTC_430 0958-0115 16.4 µM -0.471141448574502 0.314011064820439 no 2315 0.318769863889446 3209 6833180 SGTC_703 3875-0075 71.8 µM -0.471275508273621 0.31396130816483 no 2316 0.318722001597604 3240 2850814 SGTC_2515 chrysin 20.77 µM -0.471815336027331 0.313760983728542 no 2317 0.31852930170293 3285 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_809 3998-0021 90 µM -0.473980455213765 0.312958082692738 no 2318 0.3177569223681 3333 715485 SGTC_2611 pyromycin 23.93 µM -0.474514899047614 0.312760028687493 no 2319 0.317566387984196 3236 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2090 5301565 104.445 µM -0.475281525828762 0.31247602677605 no 2320 0.317293162506739 3251 2056344 SGTC_2313 7726885 200 µM -0.475407951983648 0.312429202069334 no 2321 0.317248113833275 3318 726423 SGTC_850 0388-0143 75.9 µM -0.475951393841177 0.312227960921492 no 2322 0.31705450329538 3237 67273 SGTC_1831 st055328 12 µM -0.478513492105938 0.311279949392075 no 2323 0.316142386825895 3345 1103068 SGTC_1181 1222-0449 220 µM -0.479087573950244 0.311067702470769 no 2324 0.315938164659329 3391 658318 SGTC_1654 st012436 41.8 µM -0.479819400333376 0.310797226045311 no 2325 0.315677908355148 3324 4323132 SGTC_1089 terbinafine 2.25 µM -0.482041341145842 0.309976643484541 no 2326 0.314888289291931 3341 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2379 9035213 200 µM -0.484002934473638 0.309252995248542 no 2327 0.314191893270105 3374 646551 SGTC_3109 9122853 49.47 µM -0.484040761529849 0.309239047787336 no 2328 0.314178470567315 3299 1234709 SGTC_3282 9108498 15.4605 µM -0.484875377005856 0.308931381232064 no 2329 0.313882374857759 3309 16459645 SGTC_2557 derrustone 83.84 µM -0.485681928231544 0.308634187391809 no 2330 0.313596349299228 3353 629853 An antioxidant. SGTC_1935 st074532 41.6 µM -0.487189395177902 0.308079059804322 no 2331 0.313062059936346 3342 2829742 SGTC_1067 clotrimazole 1.36 µM -0.487353944118343 0.308018490882602 no 2332 0.313003762818113 3266 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3286 9117135 37.221 µM -0.487396748507594 0.308002735845329 no 2333 0.312988598658058 3231 3438150 SGTC_1416 3966-0321 25.3 µM -0.489188722380798 0.307343480725883 no 2334 0.312354046503984 3294 582530 YLR208W SEC13 SGTC_232 clozapine 119 µM -0.489367237772618 0.307277840149718 no 2335 0.312290863216915 3304 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1691 st019933 84.6 µM -0.49004125172412 0.307030059130294 no 2336 0.312052354194606 3323 6176082 SGTC_2721 ifenprodil 61.44 µM -0.490251578483699 0.306952756834355 no 2337 0.311977943324803 3384 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2078 5212016 200 µM -0.491484278841434 0.306499869810774 no 2338 0.311541984320629 3304 1899708 SGTC_2167 5876490 200 µM -0.491777808155251 0.306392072342904 no 2339 0.311438213124985 3412 686534 SGTC_557 1315-0110 16.2 µM -0.494350234676027 0.305448076583758 no 2340 0.310529426711919 3270 6833801 SGTC_168 3970-0862 530.542 µM -0.495744851380544 0.30493683789416 no 2341 0.310037219267119 3338 3135186 SGTC_1355 1499-0035 1.68 µM -0.498104294910007 0.304072779719802 no 2342 0.309205266761971 3280 1548538 SGTC_998 3996-0085 177 µM -0.501253741192037 0.302921116290408 no 2343 0.308096278360178 3284 715391 SGTC_1667 st014849 34.6 µM -0.501272186533385 0.302914377104794 no 2344 0.308089788499752 3336 5348460 SGTC_2389 9091542 195.52 µM -0.502085530155516 0.302617280820156 no 2345 0.307803679090523 3306 3626624 YOL127W RPL25 SGTC_535 2293-4129 48.2 µM -0.503018339333227 0.302276707285148 no 2346 0.307475689172371 3404 396118 YIL048W NEO1 SGTC_287 k060-0039 29.6 µM -0.503476060269048 0.302109653887629 no 2347 0.307314803777857 3392 5861974 SGTC_2992 9074591 71.4286 µM -0.506804860953411 0.300895997861355 no 2348 0.306145872650719 3401 17741321 SGTC_1305 1181-0477 144 µM -0.506872524296911 0.300871351124083 no 2349 0.306122132605005 3414 6252086 SGTC_1475 4092-1048 11.7 µM -0.507376706487003 0.30068772872373 no 2350 0.305945263230639 3387 2881759 SGTC_366 0181-0206 4.31 µM -0.509368596862932 0.299962780378887 no 2351 0.305246941888637 3473 274874 SGTC_2529 gangaleoidin 93.61 µM -0.509735602767322 0.299829294946819 no 2352 0.305118353344354 3278 4565183 SGTC_2693 st077581 40.7 µM -0.510060580701749 0.299711118159988 no 2353 0.30500451029753 3392 25238761 SGTC_3000 9075062 71.4286 µM -0.510666841564995 0.299490710493842 no 2354 0.30479218144638 3278 17057871 SGTC_3330 9141424 71.43 µM -0.510952481897531 0.299386890701215 no 2355 0.304692165298687 3387 27261020 SGTC_2710 st078562 53.7235 µM -0.51166166925053 0.29912919767984 no 2356 0.304443908489866 3311 17250908 SGTC_2240 6690706 185.951 µM -0.512164692252374 0.2989464783778 no 2357 0.304267875784263 3202 805876 SGTC_320 4092-0846 5.34 µM -0.512425518308129 0.298851755247685 no 2358 0.304176617656547 3346 1359356 SGTC_812 4251-0442 148 µM -0.512475162449406 0.298833727733226 no 2359 0.304159249487355 3390 5723007 SGTC_2400 5203494 178.7 µM -0.515701701356836 0.297663120584447 no 2360 0.303031383086857 3375 6777674 SGTC_456 gingerol 170 µM -0.51673530424601 0.29728856644041 no 2361 0.302670473819023 3462 442793 A herb. SGTC_1562 morin hydrate 59.1 µM -0.516772475874778 0.297275100301488 no 2362 0.302657497968496 3430 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1314 1222-0010 41.1 µM -0.517666509299633 0.296951303471298 no 2363 0.302345484422632 3339 3526027 SGTC_1490 4089-0339 670 nM -0.517989979974995 0.296834190143626 no 2364 0.302232630204596 3398 742542 SGTC_1411 3909-8223 150 µM -0.518291177659678 0.296725159815535 no 2365 0.302127563708775 3398 X1411 SGTC_1049 3226-0134 66 µM -0.518411176268943 0.296681726715906 no 2366 0.302085709278662 3391 5702385 SGTC_2113 5491891 107.031 µM -0.51849548220803 0.296651214201483 no 2367 0.302056305686372 3345 789979 SGTC_3067 9117431 49.47 µM -0.518590567654744 0.296616802027302 no 2368 0.302023144040655 3309 17150885 SGTC_1700 st030840 7.9285 µM -0.518922713525528 0.296496610164799 no 2369 0.301907318919235 3389 5499307 SGTC_2338 7999974 200 µM -0.519188775913869 0.296400347683269 no 2370 0.301814552672278 3379 315925 SGTC_344 k064-0035 6.43 µM -0.519712943821545 0.296210743475969 no 2371 0.301631831941113 3268 5088750 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.520450188308169 0.295944158517538 no 2372 0.301374918659593 3357 676296 Flavone; oxidizing agent. SGTC_290 2043-6722 48.1 µM -0.520465856577553 0.295938494123258 no 2373 0.301369459685926 3385 773758 YLR208W SEC13 SGTC_1525 8-methoxypsoralen 92.5 µM -0.520776590909693 0.295826167701918 no 2374 0.301261206094424 3479 4114 Related to psoralen; DNA damaging agent. SGTC_3203 9113543 49.47 µM -0.522151197355118 0.295329500447556 no 2375 0.300782531099022 3404 17018012 SGTC_101 0490-5701 117.494 µM -0.524089255900571 0.294629901582485 no 2376 0.300108230523957 3377 4661669 SGTC_1170 0310-0127 64.8 µM -0.524359961177996 0.294532243483329 no 2377 0.300014099617403 3347 774975 SGTC_933 2914-0560 114 µM -0.525101642560232 0.294264755275654 no 2378 0.299756267158489 3441 463887 SGTC_573 3702-0553 84.7 µM -0.52578431004067 0.294018649713481 no 2379 0.299519038570732 3373 1222756 SGTC_1594 piperine 70.1 µM -0.526079196130573 0.293912371015172 no 2380 0.299416591272212 3357 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_799 1310-0557 151 µM -0.526456288404752 0.293776490612058 no 2381 0.299285607621612 3444 5354492 SGTC_2871 9038510 12.99 µM -0.526556863784345 0.293740254464311 no 2382 0.299250676981954 3462 4945164 SGTC_1126 isoteolin 1.0172 µM -0.526568026127495 0.293736232928503 no 2383 0.299246800324284 3361 133323 SGTC_579 4491-1009 110 µM -0.528826629649942 0.29292303465632 no 2384 0.298462861435479 3489 1271041 SGTC_1342 1486-1464 234 µM -0.529346151849744 0.292736131337407 no 2385 0.298282672706326 3378 3253938 SGTC_304 1310-0298 97 µM -0.529628165793543 0.292634697190759 no 2386 0.298184881011393 3390 1550234 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.52976027679574 0.292587185416677 no 2387 0.298139074970614 3423 5377381 SGTC_67 0335-0847 266 µM -0.530075215018997 0.292473936986984 no 2388 0.298029891295367 3526 4552207 YOR254C SEC63 SGTC_1962 st076595 64.5 µM -0.53040843986647 0.292354135070435 no 2389 0.297914387805426 3353 279619 SGTC_2968 9090663 33.37 µM -0.531601178378682 0.291925505563018 no 2390 0.29750112423123 3295 25236811 SGTC_1766 st045414 44.774 µM -0.532849872615658 0.291477081312462 no 2391 0.297068753631977 3428 253960 SGTC_1459 k035-0031 35.7 µM -0.532980908347441 0.291430043109448 no 2392 0.297023398102081 3327 3877128 YMR208W ERG12 SGTC_442 cape 100 µM -0.534009180311648 0.291061044907565 no 2393 0.29666759128968 3412 5281787 SGTC_3344 9148862 3.898 µM -0.53422662863325 0.29098304094782 no 2394 0.296592373955063 3472 4905352 SGTC_1776 st049249 45.9 µM -0.53565484859661 0.290470946912426 no 2395 0.296098557067159 3375 1822314 SGTC_484 loperamide 105 µM -0.536382273350351 0.290210288069094 no 2396 0.295847190056597 3364 3955 An opioid-receptor agonist. SGTC_2348 9022543 33.42 µM -0.536945754497637 0.29000845065324 no 2397 0.295652542367495 3427 3162678 YDL140C RPO21 SGTC_86 0417-1630 471.922 µM -0.537440753233825 0.289831197768039 no 2398 0.295481599674279 3422 3634867 SGTC_2731 amoxapine 43.43 µM -0.537898090129635 0.289667476300832 no 2399 0.295323703519872 3423 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_313 3474-0040 5.03 µM -0.538372819349481 0.289497574507559 no 2400 0.295159843724764 3360 1043375 YIL048W NEO1 SGTC_1770 st043884 66.3 µM -0.538719514454911 0.289373524678182 no 2401 0.295040203248891 3422 670149 SGTC_996 3970-0799 1.8 µM -0.541206898840123 0.288484255105123 no 2402 0.294182491452394 3430 6615648 YGL040C HEM2 SGTC_2753 fluvastatin 17.09 µM -0.541296005755389 0.288452422229622 no 2403 0.294151786564917 3377 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2685 mycophenolic acid 18.85 µM -0.541432900400988 0.288403520718872 no 2404 0.294104617637872 3360 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2394 5221648 200 µM -0.541508084806325 0.2883766650053 no 2405 0.294078713307435 3433 788586 SGTC_1118 chelidonine 707.474 nM -0.54194362094452 0.288221115601994 no 2406 0.293928672728288 3454 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2333 9017922 200 µM -0.542322223493667 0.288085931888604 no 2407 0.293798274327994 3445 3163164 SGTC_103 0844-0104 51.839 µM -0.543182056288816 0.287779031438936 no 2408 0.293502229926391 3472 5375804 SGTC_1173 0443-0020 122 µM -0.543443459264618 0.28768575939918 no 2409 0.293412255068582 3358 5331295 SGTC_1367 1812-0510 76.9 µM -0.543457573541853 0.287680723644872 no 2410 0.293407397300501 3381 1142582 YDR527W RBA50 SGTC_1806 st050005 60.3 µM -0.545126238141616 0.287085663889631 no 2411 0.292833349028451 3363 5194765 SGTC_2985 9022375 71.43 µM -0.546431870020006 0.286620471451552 no 2412 0.292384553931407 3510 4939335 SGTC_2109 5483026 200 µM -0.546498310122954 0.286596808618767 no 2413 0.292361724506875 3390 759335 SGTC_92 0063-0024 660.874 µM -0.546672894709931 0.286534634235262 no 2414 0.292301739603578 3448 3594437 SGTC_628 1636-0253 16 µM -0.547090034108006 0.286386105313145 no 2415 0.292158439329487 3405 4456143 SGTC_2600 tangeritin 87.95 µM -0.547337260200401 0.286298093897268 no 2416 0.292073524958466 3398 68077 A bioactive flavone. SGTC_829 1635-0120 117 µM -0.548539517647137 0.285870278636525 no 2417 0.291660751275446 3438 285054 SGTC_742 0kpi-0133 140 µM -0.549376148762413 0.285572748527895 no 2418 0.291373669431412 3453 2728852 SGTC_404 fumagillin 50 µM -0.549557858162171 0.285508146921298 no 2419 0.29131133504775 3406 12015870 A methionine aminopeptidase binder. SGTC_214 4373-3496 70 µM -0.549932957816437 0.285374812920363 no 2420 0.291182678917103 3512 3779166 SGTC_1469 k284-2957 126 µM -0.550631851852808 0.285126461172163 no 2421 0.29094303474004 3411 23884841 SGTC_1198 1612-1005 86.7 µM -0.551101233792047 0.284959724316234 no 2422 0.290782139850335 3529 6998509 SGTC_2462 5162487 171.77 µM -0.55121385066486 0.284919726748176 no 2423 0.290743543192039 3428 2259986 SGTC_3319 9138450 16.7555 µM -0.551540917133466 0.284803579380796 no 2424 0.290631462803111 3349 2029690 SGTC_451 chloral hydrate 100 µM -0.553589532403294 0.284076592539628 no 2425 0.289929895703022 3449 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1297 1068-0111 14.1 µM -0.554477950812481 0.283761597956123 no 2426 0.289625895744757 3372 767057 SGTC_803 4488-1585 147 µM -0.554734058265153 0.28367082444182 no 2427 0.289538288416689 3441 747204 SGTC_2369 9071472 200 µM -0.554938258791279 0.283598458540368 no 2428 0.289468445940475 3452 17296037 SGTC_1070 indatraline 8.81 µM -0.555658265728638 0.28334336842844 no 2429 0.289222245939181 3396 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3266 9136860 49.47 µM -0.556030582495256 0.283211504083192 no 2430 0.289094974138044 3412 4871271 YPR165W RHO1 SGTC_1454 4239-0054 42.6 µM -0.556710440384136 0.282970793127922 no 2431 0.288862641258273 3555 1340767 SGTC_40 0327-0103 19.753 µM -0.557443881919806 0.282711220499714 no 2432 0.288612095428235 3352 409036 SGTC_748 act1.228 77.9 µM -0.558208167065138 0.282440853786741 no 2433 0.288351122296198 3425 4421505 YNR035C ARC35 SGTC_331 k048-0133 24.5 µM -0.558840656963111 0.282217203864825 no 2434 0.288135236198136 3420 6813582 SGTC_346 4513-0042 7.16 µM -0.559237751211003 0.282076833969447 no 2435 0.287999736054662 3435 2827372 SGTC_64 000l-0018 272.079 µM -0.561061460876515 0.281432598119241 no 2436 0.287377819725613 3436 6811119 SGTC_794 k038-0031 316 µM -0.56259379301546 0.280891842526417 no 2437 0.286855759797388 3507 6624242 SGTC_2625 euphol 100 µM -0.563442366895746 0.280592599491424 no 2438 0.286566847284229 3480 6708538 A triterpene alcohol. SGTC_340 k038-0059 454 µM -0.563508036767169 0.28056944794984 no 2439 0.286544494529727 3429 23733424 SGTC_873 0591-4978 488 µM -0.563847506315358 0.280449784623256 no 2440 0.286428958850262 3560 3305145 SGTC_883 0850-0245 24.6 µM -0.566802480134234 0.27940919850721 no 2441 0.285424192691951 3509 6823229 YPR165W RHO1 SGTC_125 0133-0007 11.75 µM -0.567846920347506 0.279041850786759 no 2442 0.285069458370855 3531 26541 SGTC_653 0203-0016 55.2 µM -0.568461528595607 0.278825792243724 no 2443 0.284860810727004 3423 295302 SGTC_684 1140-0066 328 µM -0.570721570692085 0.278032000976323 no 2444 0.284094197217697 3473 6813534 SGTC_3316 9136639 10.545 µM -0.571400463584836 0.277793769952829 no 2445 0.283864107459991 3476 4903665 SGTC_22 0964-0034 14.468 µM -0.571522208838775 0.277751058738863 no 2446 0.283822855104409 3451 138402 SGTC_2491 paeonol 100 µM -0.571863300445466 0.277631412538718 no 2447 0.283707294368566 3453 11092 Increases levels of cortical cytochrome oxidase. SGTC_1046 2001-0062 216 µM -0.572105055516667 0.277546626301243 no 2448 0.283625402178544 3427 739778 SGTC_904 1141-0088 396 µM -0.572913493571943 0.277263189869663 no 2449 0.283351633893659 3446 1378119 SGTC_544 k015-0020 52.4 µM -0.574567318322915 0.276683804319767 no 2450 0.282791980149253 3460 3008304 SGTC_1565 sinapyl alcohol 95.1 µM -0.574880150346281 0.276574276425876 no 2451 0.2826861776482 3455 5280507 A phenol propionate derived from cinnamic acid. SGTC_2499 avocadenofuran 51.48 µM -0.576230517697128 0.276101733520225 no 2452 0.282229690114659 3354 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2869 9037858 32.47 µM -0.577470738104105 0.275668084529853 no 2453 0.281810750207091 3460 27187042 SGTC_1259 0671-0132 43 µM -0.578240048374872 0.275399259888345 no 2454 0.281551031958598 3381 X1259 SGTC_1027 k015-0025 8.67 µM -0.578815830359817 0.275198145412325 no 2455 0.281356724205174 3466 3598955 SGTC_1365 1672-3266 55.4 µM -0.580425709600095 0.274636215865828 no 2456 0.280813785883331 3499 6415873 SGTC_1398 3558-0053 112 µM -0.580441243545047 0.274630796488685 no 2457 0.280808549465823 3383 4532369 SGTC_1362 1611-0397 101 µM -0.581273682081886 0.274340458162429 no 2458 0.280528007551461 3456 27816 SGTC_918 glabranin 770.725 nM -0.583679234069324 0.273502301150873 no 2459 0.279718070469391 3474 124049 Also referred to as licorice root. SGTC_2736 butenafine 14.65 µM -0.586354827041961 0.27257154620684 no 2460 0.278818547027247 3457 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1186 1319-0216 26 µM -0.586373573719027 0.272565030376761 no 2461 0.278812249440571 3547 4565136 SGTC_1439 4092-1168 46 µM -0.589009274827603 0.271649703500555 no 2462 0.277927525934943 3486 2886240 SGTC_2393 9031399 185.94 µM -0.58982760596228 0.271365824933041 no 2463 0.277653116449154 3556 1526623 YDL150W RPC53 SGTC_865 0488-0499 301 µM -0.589995997853613 0.271307428233834 no 2464 0.277596666327344 3528 9634651 SGTC_2805 7950783 58.44 µM -0.590274660440616 0.271210804470989 no 2465 0.277503262409088 3482 1178958 YDL195W SEC31 SGTC_2361 9034121 116 µM -0.591205250329671 0.270888255098054 no 2466 0.277191452645351 3443 6496917 SGTC_3231 9132313 49.47 µM -0.59184432780361 0.27066685702525 no 2467 0.276977418329375 3463 4905967 SGTC_1930 st074634 34.3 µM -0.592944694613976 0.270285864570912 no 2468 0.276609082658046 3474 684253 YOR116C RPO31 SGTC_752 1896-0090 130 µM -0.593620051972273 0.270052160807279 no 2469 0.276383133177308 3511 772567 SGTC_1523 st012844 44.7 µM -0.593911936577703 0.269951187017196 no 2470 0.276285507458235 3502 4274103 SGTC_757 1066-0008 322 µM -0.59414467025953 0.269870689283631 no 2471 0.276207677886678 3514 6842497 SGTC_2701 st077767 14.721 µM -0.595606166337566 0.269365463054935 no 2472 0.275719178151841 3499 5721188 SGTC_2438 5259590 200 µM -0.596845712965887 0.268937334774813 no 2473 0.275305197304871 3479 1201127 SGTC_2684 capsaicin 100 µM -0.597529858634937 0.268701183401582 no 2474 0.275076839049811 3528 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1359 1582-0056 520 nM -0.597534761233682 0.268699491513121 no 2475 0.275075202967651 3529 3661189 SGTC_672 1441-0018 53.7 µM -0.599953911607204 0.267865295388719 no 2476 0.274268475748802 3471 251141 SGTC_3251 9135047 49.47 µM -0.600746374331943 0.267592314234692 no 2477 0.274004463163768 3500 17682963 SGTC_1676 st018489 23.4 µM -0.601033515226168 0.267493436886082 no 2478 0.273908831868995 3456 3696235 SGTC_1109 tnp00067 928.257 nM -0.60107573676461 0.26747889939707 no 2479 0.273894771521299 3470 676295 SGTC_2444 5485484 36.41 µM -0.601212451561973 0.267431829240327 no 2480 0.273849246079042 3554 6790631 SGTC_27 0485-0001 32.618 µM -0.60220351898955 0.267090735110399 no 2481 0.2735193367808 3481 2054479 SGTC_728 3030-5151 22.5 µM -0.603180751925462 0.266754617583599 no 2482 0.273194225482643 3538 3125388 SGTC_1596 piperlongumine 63 µM -0.603501355083336 0.266644393289331 no 2483 0.273087607164105 3547 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.604044502854217 0.266457710076821 no 2484 0.272907027505032 3490 77254 SGTC_3250 9135583 49.47 µM -0.604280270760887 0.266376695788245 no 2485 0.272828660479567 3534 7699353 SGTC_2894 9048625 32.47 µM -0.605537472235869 0.265944908233704 no 2486 0.272410967137538 3602 4092861 SGTC_119 0121-0043 24.815 µM -0.605861305904272 0.265833744582506 no 2487 0.272303427919078 3593 1092378 SGTC_2975 9084847 53.72 µM -0.607851459940875 0.265151094093518 no 2488 0.271642997780508 3497 27211724 SGTC_2508 celastrol 40.54 µM -0.60803923270697 0.265086731418153 no 2489 0.27158072681745 3488 122724 Celastrol is a natural product and antioxidant. SGTC_580 1123-0028 41 µM -0.608739080984225 0.264846915083701 no 2490 0.271348699216169 3589 1677248 YPR107C YTH1 SGTC_1016 4226-1401 38 µM -0.610362670377072 0.264290986289509 no 2491 0.270810795318906 3525 2901613 SGTC_1713 st033146 12.748 µM -0.611256086237767 0.263985327845895 no 2492 0.270515029035433 3559 674619 SGTC_3156 9099931 49.47 µM -0.613481485660326 0.263224750761875 no 2493 0.269779010526021 3508 18111053 SGTC_503 tyrphostin 8 294 µM -0.613698932119942 0.263150493931639 no 2494 0.269707147086058 3526 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2404 5161160 200 µM -0.613825072399346 0.263107422590647 no 2495 0.269665463635333 3540 2831543 SGTC_2934 9036370 36.88 µM -0.614785065614131 0.262779745325805 no 2496 0.269348336642968 3509 6462800 SGTC_1420 4'-methoxyflavone 42 µM -0.614919391605347 0.262733912098097 no 2497 0.269303977916606 3542 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2966 9084041 48.03 µM -0.616277243239114 0.262270830707327 no 2498 0.268855777799099 3426 17741380 SGTC_1299 1079-1439 3.74 µM -0.61809855935568 0.261650346674758 no 2499 0.268255185947609 3470 323161 SGTC_386 1509-0011 3.07 µM -0.618323446564335 0.261573784625065 no 2500 0.268181074647034 3576 3107280 SGTC_1773 st048542 73.5835 µM -0.619383707869193 0.261212977413981 no 2501 0.267831805704778 3489 3237138 SGTC_2014 4013930 200 µM -0.619505066513058 0.261171695351539 no 2502 0.26779184262779 3540 64556 SGTC_1160 4092-0570 10.5 µM -0.620078657875378 0.26097662455966 no 2503 0.267603001189408 3548 4994975 SGTC_1437 4092-1038 11.6 µM -0.623473354739177 0.25982366904717 no 2504 0.266486753325845 3541 3977136 SGTC_431 k089-0097 107 µM -0.62432630590461 0.259534391238286 no 2505 0.266206655689218 3532 5499420 SGTC_837 0091-0265 12.5 µM -0.624477864822864 0.259483007540924 no 2506 0.266156901387189 3510 759367 SGTC_1612 st002233 45.4 µM -0.625014985539014 0.25930094741841 no 2507 0.265980611402733 3578 1035021 SGTC_1051 3253-3903 78 µM -0.626019257639867 0.258960720847848 no 2508 0.265651155047755 3520 5509239 SGTC_2123 5259487 200 µM -0.626314704023497 0.258860673712507 no 2509 0.265554271831392 3547 2173474 SGTC_781 4335-2806 94.4 µM -0.626797945982274 0.258697076398465 no 2510 0.265395845052341 3614 845254 SGTC_772 k072-0172 35.3 µM -0.626821154965615 0.258689220548506 no 2511 0.265388237391255 3478 5861980 SGTC_1923 st058458 19.1 µM -0.626947484899231 0.258646462159316 no 2512 0.265346829706055 3621 3534982 SGTC_3356 9151811 4.48 µM -0.627148506889479 0.25857843059177 no 2513 0.265280946657573 3513 1859254 YPR165W RHO1 SGTC_2696 st077691 74.316 µM -0.62968042003023 0.257722353084189 no 2514 0.264451847785828 3551 757133 SGTC_1077 5-fluorocytosine 377 nM -0.630989749972389 0.25728022700388 no 2515 0.264023613237815 3543 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2151 5563267 85.4165 µM -0.63160966733081 0.257071034913465 no 2516 0.263820983984201 3555 5310824 SGTC_839 0122-0028 230 µM -0.631951321003411 0.256955781166836 no 2517 0.263709343277566 3558 759448 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.632189227759598 0.256875541375673 no 2518 0.263631617740505 3684 5282309 SGTC_74 000s-0487 160.283 µM -0.633023410558556 0.256594296157004 no 2519 0.263359177678591 3548 677548 SGTC_2226 7298446 200 µM -0.633024220917533 0.256594023021993 no 2520 0.263358913089183 3569 3283010 SGTC_1769 st044406 64.4 µM -0.634420523214736 0.2561236182797 no 2521 0.262903209670217 3543 670903 SGTC_3022 9087993 49.47 µM -0.635310145623567 0.255824145267648 no 2522 0.262613078954973 3590 17173644 SGTC_2840 9008771 71.43 µM -0.636353988969447 0.255472990146458 no 2523 0.262272861517156 3530 2992978 SGTC_1912 st060209 90.8 µM -0.636515833711169 0.255418567170859 no 2524 0.262220132059973 3540 688787 SGTC_1512 0259-0544 12.2 µM -0.636915844283226 0.255284082985382 no 2525 0.262089830831787 3573 18476 SGTC_2961 9083290 32.55 µM -0.637940402934007 0.25493979365455 no 2526 0.261756237944664 3549 17741490 SGTC_200 k038-0079 37.545 µM -0.638003779989476 0.254918504619248 no 2527 0.261735609742703 3523 3436683 SGTC_160 3453-0671 289.699 µM -0.638651394843683 0.254701017153023 no 2528 0.261524869444569 3531 5322268 SGTC_3195 9113082 49.47 µM -0.639163244590588 0.254529192236666 no 2529 0.26135837011253 3557 17018038 SGTC_2534 helenine 20.12 µM -0.639793399774644 0.25431773632301 no 2530 0.261153462069544 3583 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2327 6189656 200 µM -0.639927550084915 0.254272732515439 no 2531 0.261109850972279 3582 5349088 SGTC_3190 9110366 49.47 µM -0.640286973306443 0.254152176310103 no 2532 0.260993024067317 3520 17123768 SGTC_368 fentichlor 4.58 µM -0.640729240171176 0.25400387419124 no 2533 0.260849306561039 3528 7329 A pesticide. SGTC_666 0272-0154 136 µM -0.640949789587584 0.253929935935979 no 2534 0.260777652802907 3573 6870312 SGTC_1661 st013063 9.66 µM -0.64199186216766 0.253580738349529 no 2535 0.260439233419923 3613 721395 SGTC_2152 5568786 200 µM -0.643963678881599 0.252920675243698 no 2536 0.259799493478872 3570 5399883 SGTC_3158 9100007 49.47 µM -0.646676125253797 0.25201416695187 no 2537 0.258920789011171 3574 19297233 SGTC_1864 st057645 30.4 µM -0.647175464081785 0.251847473357991 no 2538 0.258759194553618 3624 688666 SGTC_2931 9014674 55.67 µM -0.647191563177322 0.251842099987785 no 2539 0.258753985483762 3585 2996810 SGTC_300 r073-0011 5.04 µM -0.648310403858744 0.251468814571016 no 2540 0.258392103158544 3644 2735780 SGTC_2298 7976326 193.81 µM -0.648446792751741 0.251423330342335 no 2541 0.258348006924833 3498 2235818 SGTC_154 3389-1638 511.116 µM -0.648791622431455 0.251308352749989 no 2542 0.258236536574545 3511 5238686 SGTC_1954 st077032 68.9 µM -0.649676651299904 0.251013382204783 no 2543 0.257950554472136 3538 698907 SGTC_2779 methotrexate 400 µM -0.652233149652492 0.250162358908309 no 2544 0.257125388999793 3655 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_495 decylubiquinone 155 µM -0.652654502036805 0.25002224351071 no 2545 0.256989520230183 3565 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1714 st033236 13.627 µM -0.65279023495102 0.249977116118728 no 2546 0.256945759917217 3653 2916566 SGTC_1121 fusaric acid 630.51 nM -0.65310548364157 0.24987232143941 no 2547 0.256844138650422 3586 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1218 1348-1416 30.7 µM -0.656015910946789 0.248905942350863 no 2548 0.255906943434925 3602 6787668 SGTC_572 0960-0087 17.7 µM -0.656027746744814 0.248902016454593 no 2549 0.255903135801618 3576 6796365 SGTC_2474 5321570 43.32 µM -0.657727407550007 0.248338586771993 no 2550 0.25535665383645 3610 2841384 SGTC_2342 7990637 118.86 µM -0.658333882479325 0.248137707852584 no 2551 0.255161805268144 3638 2033102 YER133W GLC7 SGTC_1844 rapamycin 4 nM -0.660251253537724 0.247503199514119 no 2552 0.254546303190338 3602 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_939 1165-0479 45.3 µM -0.660600265683995 0.247387795581961 no 2553 0.254434349299607 3563 1377347 SGTC_2809 7964133 12.99 µM -0.661148644711385 0.24720652735126 no 2554 0.254258495908881 3602 1253665 SGTC_590 k048-0076 22.4 µM -0.661551704130127 0.247073340227112 no 2555 0.254129284042975 3616 6832814 SGTC_56 0957-0365 83.25 µM -0.663570406531712 0.246406857333405 no 2556 0.253482651622443 3584 6752360 SGTC_2634 4'-methoxyflavone 100 µM -0.664329100077195 0.246156620877828 no 2557 0.25323984999769 3600 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2003 4023581 200 µM -0.664644673048843 0.24605257702116 no 2558 0.253138894480354 3636 16641307 SGTC_534 k292-0788 63.4 µM -0.664726446594917 0.246025620275188 no 2559 0.253112737611858 3668 4146317 SGTC_3326 9140064 16.379 µM -0.666161622026505 0.24555277102844 no 2560 0.252653900206654 3606 1868434 SGTC_2807 7945238 51.95 µM -0.666163430545147 0.245552175481422 no 2561 0.252653322284851 3637 17148797 SGTC_1665 st014639 11.4 µM -0.66844003933629 0.244803101531436 no 2562 0.251926372221385 3690 981133 YIL048W NEO1 SGTC_3307 9126885 69.2785 µM -0.66891240199255 0.244647833990996 no 2563 0.251775679237501 3613 24824909 SGTC_649 1123-0311 367 µM -0.669933711358577 0.244312306784657 no 2564 0.25145002421638 3610 693629 YIL048W NEO1 SGTC_1486 3970-0793 4.53 µM -0.670560529851265 0.24410650318083 no 2565 0.251250266968285 3652 2844330 SGTC_2390 9097792 176.6 µM -0.67123867868319 0.243883951598942 no 2566 0.251034246082444 3604 4497149 SGTC_2228 7354201 200 µM -0.672207864578023 0.243566079041501 no 2567 0.250725687474042 3652 753451 SGTC_877 0771-0151 33.1 µM -0.672359489111904 0.243516369637873 no 2568 0.250677433118775 3630 6166523 SGTC_2408 sulbentine 18.36 µM -0.672902549420324 0.243338374793532 no 2569 0.250504645086721 3604 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2070 5230947 200 µM -0.672959442765364 0.24331973135405 no 2570 0.250486546718524 3699 2835538 SGTC_490 phenamil 164 µM -0.673441107733708 0.243161924996398 no 2571 0.25033335182232 3566 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_479 n-linoleoylglycine 10 µM -0.674189890720056 0.242916713532515 no 2572 0.250095297951933 3626 6433346 An anti-infammatory. SGTC_537 1334-0398 209 µM -0.674909197529384 0.242681280975399 no 2573 0.249866728320939 3629 5846986 SGTC_2955 9076254 12.21 µM -0.675288706685907 0.242557115613519 no 2574 0.249746178768693 3564 16459619 SGTC_2524 avocatin b 10.57 µM -0.676139630321279 0.242278840993386 no 2575 0.249475998601862 3580 6710748 SGTC_131 0141-0277 33.849 µM -0.676314971024211 0.242221521435871 no 2576 0.249420344780667 3600 1547771 SGTC_2037 5169046 200 µM -0.676842142475737 0.242049231320585 no 2577 0.249253058262598 3648 5718022 SGTC_1292 0kpi-0043 232 µM -0.677124767023797 0.241956891369663 no 2578 0.249163398015246 3630 3333905 SGTC_1165 k072-0275 30.3 µM -0.680885985726487 0.24072983575799 no 2579 0.24797181817144 3660 6153523 YGL055W OLE1 SGTC_318 1488-0629 67.2 µM -0.680990866779548 0.240695668087559 no 2580 0.247938634770593 3649 3662576 SGTC_306 1672-3436 11.6 µM -0.681317529086205 0.240589266448077 no 2581 0.247835297007176 3662 6797378 SGTC_1687 st020778 55.3625 µM -0.681596469407008 0.240498429261145 no 2582 0.247747074024894 3646 4259299 SGTC_335 4077-0256 27.6 µM -0.681717471103797 0.240459030749635 no 2583 0.247708808937565 3668 3121989 SGTC_493 zm226600 134 µM -0.681958361152753 0.240380606700556 no 2584 0.247632640239287 3669 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2284 7945075 39.21 µM -0.682041937726585 0.240353400807064 no 2585 0.247606216505107 3709 1245402 SGTC_2566 crystal violet carbinol 226 nM -0.683342984419239 0.239930099732605 no 2586 0.247195069306178 3597 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1331 1472-0049 76.2 µM -0.684174070887095 0.23965991517207 no 2587 0.246932626695637 3632 24051409 SGTC_1360 1598-0022 39.8 µM -0.6853230750956 0.239286649830638 no 2588 0.246570036929607 3679 761525 SGTC_509 pifithrin 175 µM -0.687683847015268 0.238520727453072 no 2589 0.245825947095626 3686 4817 A p53 inhibitor. SGTC_280 3448-3607 3.04 µM -0.68876442506577 0.238170595913359 no 2590 0.245485763105268 3643 626179 SGTC_2647 atorvastatin 60.16 µM -0.689279519967295 0.238003792774337 no 2591 0.245323691705058 3642 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_725 1497-0963 19 µM -0.689444711795764 0.237950312283026 no 2592 0.245271727308724 3682 3549977 SGTC_2476 5806916 10.51 µM -0.689547760458819 0.237916953842081 no 2593 0.24523931428625 3580 2870194 SGTC_1800 st050079 29.0735 µM -0.690056972238977 0.237752151785091 no 2594 0.245079180150913 3623 3645560 SGTC_1392 3455-1037 33.9 µM -0.690444457166665 0.237626787553545 no 2595 0.244957363702489 3668 981132 SGTC_909 3448-9333 149 µM -0.690980001136081 0.237453581034326 no 2596 0.24478905450242 3620 3344074 SGTC_1328 1441-0025 69.2 µM -0.691737764550385 0.237208622389499 no 2597 0.244551013218506 3612 4562601 SGTC_2417 cerulenin 830 nM -0.691797088613914 0.23718945083702 no 2598 0.244532382618375 3718 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1740 st038286 13.222 µM -0.692101111416329 0.237091214199188 no 2599 0.244436916882847 3673 716786 SGTC_2741 miltefosine 3.04 µM -0.692373555472331 0.237003200365386 no 2600 0.24435138420532 3596 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1863 st057641 20.1 µM -0.695050298309885 0.236139426537611 no 2601 0.243511890340459 3682 3921635 SGTC_2095 5432005 200 µM -0.696874415240405 0.235551786539578 no 2602 0.242940695219354 3680 783734 SGTC_598 3937-0236 20.2 µM -0.70011301541703 0.234510460835513 no 2603 0.241928364110503 3726 1379313 SGTC_3119 9125183 49.47 µM -0.702234547627596 0.233829695323825 no 2604 0.241266451934188 3559 22695334 SGTC_1564 D-Arginine 115 µM -0.702272759164592 0.233817443905703 no 2605 0.24125453906982 3648 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1699 st031318 29.054 µM -0.704243055184514 0.233186208086823 no 2606 0.240640711156497 3746 5340658 SGTC_2539 epi(13)torulosol 80 µM -0.704722396055684 0.233032781899648 no 2607 0.240491505517524 3672 6708597 SGTC_111 0083-0039 52.457 µM -0.70559149327643 0.232754746522478 no 2608 0.240221107966233 3601 759313 SGTC_138 0850-0259 40.9225 µM -0.70608025990823 0.232598464816551 no 2609 0.240069113447468 3706 6813004 SGTC_1870 st057514 26.5 µM -0.706689210385357 0.232403836320315 no 2610 0.239879818056891 3687 5393161 SGTC_1226 3909-7979 35.4 µM -0.707702865924989 0.232080059802841 no 2611 0.239564898651831 3704 6615510 SGTC_826 1683-5028 118 µM -0.707909873577293 0.232013969397766 no 2612 0.239500613910573 3727 722377 SGTC_2187 6125751 200 µM -0.709392264371214 0.231540999462339 no 2613 0.239040543420453 3685 874498 SGTC_1802 st050112 57.9 µM -0.709762605893411 0.231422922679702 no 2614 0.23892568077713 3696 4662563 SGTC_2978 9011784 42.97 µM -0.710193430618271 0.231285604167634 no 2615 0.238792097055941 3747 2994934 SGTC_1228 0124-0032 52.5 µM -0.710208562421104 0.231280781973093 no 2616 0.238787405954443 3735 X1228 SGTC_797 k781-0471 270 µM -0.710360992542442 0.231232208754645 no 2617 0.238740152984682 3690 23738129 SGTC_2043 5101342 149 µM -0.710424802593322 0.231211876802495 no 2618 0.238720373542049 3699 678451 SGTC_2576 guaiol 23.12 µM -0.712701600107277 0.230487068313694 no 2619 0.238015213067179 3704 227829 SGTC_626 0214-0009 33 µM -0.712959514886573 0.230405042434595 no 2620 0.237935404809313 3723 3437874 SGTC_2049 5262831 67.185 µM -0.71322243009394 0.230321443045584 no 2621 0.237854064339807 3730 763417 SGTC_2170 morpholine 200 µM -0.713908737453582 0.230103297214113 no 2622 0.237641807062838 3721 121171 Reacts with secondary amines. SGTC_2567 aureobasidin a 60 nM -0.715144669044755 0.22971074257998 no 2623 0.237259827342013 3787 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2638 epoxomicin 18 µM -0.715534305571441 0.229587064647619 no 2624 0.237139475376666 3707 9915668 A protesome inhibitor. SGTC_393 acivicin 6.25 µM -0.71582285618266 0.229495497326799 no 2625 0.237050368719359 3609 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2227 7312221 64.1025 µM -0.717057532809386 0.229103921948984 no 2626 0.236669298929512 3727 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1747 st037496 66.6 µM -0.71873104710319 0.228573768766653 no 2627 0.236153324934811 3734 723305 SGTC_3295 9122362 53.5725 µM -0.720172744088343 0.228117606095713 no 2628 0.235709321601162 3724 4730473 SGTC_1256 0570-0116 285 µM -0.721985551947227 0.227544748657553 no 2629 0.235151680226685 3721 410638 SGTC_1546 5-methoxyflavanone 78.7 µM -0.724086196262462 0.226881947722355 no 2630 0.23450640925813 3735 147795 SGTC_1058 3448-5425 97.3 µM -0.724440242016652 0.2267703455922 no 2631 0.234397750858485 3635 7279705 SGTC_1755 st041960 45.185 µM -0.725758974247298 0.226354928121744 no 2632 0.233993270638933 3742 2257073 SGTC_2486 5283202 22.39 µM -0.726477335553179 0.226128816113337 no 2633 0.233773098360607 3739 1377751 SGTC_1718 roemerine 11.9335 µM -0.727907417588537 0.225679062503905 no 2634 0.233335131109086 3629 235224 An aporphine alkaloid with mutagenic activity. SGTC_3023 9089636 49.47 µM -0.72857505247491 0.225469268099502 no 2635 0.233130821761152 3799 17249241 SGTC_682 0kpi-0099 17 µM -0.732880157877018 0.224119106433977 no 2636 0.231815763050331 3735 1714895 YML126C ERG13 SGTC_524 r073-0010 27.8 µM -0.733708653342408 0.223859802644915 no 2637 0.231563161720494 3671 2772106 SGTC_3322 9139058 2.11 µM -0.734115043959541 0.223732672239238 no 2638 0.231439312734186 3821 4908926 YPR165W RHO1 SGTC_3095 9117207 49.47 µM -0.734432472818529 0.223633400129078 no 2639 0.231342600857409 3706 17015229 SGTC_1826 st055655 41.6 µM -0.734626429519516 0.223572754801968 no 2640 0.23128351865992 3762 676168 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.735188086664606 0.223397191667888 no 2641 0.231112476731247 3773 5379071 SGTC_2771 fluoxetine 41.05 µM -0.736458545760111 0.223000360317363 no 2642 0.230725843289096 3716 3386 A selective serotonin reuptake inhibitor. SGTC_1597 7-benzyloxygramine 47.5 µM -0.736601772906965 0.222955648124477 no 2643 0.230682278251522 3713 260807 SGTC_254 nsc-64875 3.808 µM -0.736931993793935 0.222852580284679 no 2644 0.230581853316872 3755 56993 SGTC_1909 st060837 51.5 µM -0.736937217584262 0.222850950064511 no 2645 0.230580264883206 3752 678937 SGTC_2157 5649910 96.377 µM -0.73742276100991 0.222699453229776 no 2646 0.230432649072809 3705 2858091 SGTC_417 st075190 100 µM -0.737880882268309 0.222556566359202 no 2647 0.230293418652152 3727 222757 SGTC_905 2-aminofluorene 215 µM -0.738508345683546 0.222360946946716 no 2648 0.230102798792322 3753 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1090 efavirenz 20.7 µM -0.73861831261573 0.222326673511333 no 2649 0.230069400549948 3797 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_411 enrofloxacin 100 µM -0.740589110730981 0.221712945322038 no 2650 0.229471306244665 3789 71188 A bacterial gyrase inhibitor. SGTC_1614 st002383 48.6 µM -0.740613994352543 0.221705202481943 no 2651 0.229463760181777 3728 1947235 SGTC_2064 5220758 200 µM -0.741602209240551 0.221397832381042 no 2652 0.229164192309273 3773 788518 SGTC_124 0136-0217 7.121 µM -0.744259497632811 0.220572530443987 no 2653 0.228359749650002 3822 3976905 SGTC_1167 k781-0610 148 µM -0.745126149893488 0.220303746821834 no 2654 0.228097731031327 3770 4525169 SGTC_2623 humulene 100 µM -0.745763652256502 0.22010615169906 no 2655 0.227905100233405 3694 6187145 An anti-inflammatory. SGTC_3296 9122258 64.045 µM -0.747427987356654 0.219590767141355 no 2656 0.227402628322313 3777 4730474 SGTC_2605 digitonin 300 nM -0.748242901709281 0.219338670526113 no 2657 0.2271568289736 3777 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2571 chrysanthemic acid 100 µM -0.748357447213464 0.219303248809115 no 2658 0.227122291081209 3767 2743 An insecticide. SGTC_1988 st071872 53.4 µM -0.750085346538482 0.2187693172613 no 2659 0.226601652162001 3755 16414116 SGTC_1783 st039459 87.517 µM -0.750148068463899 0.218749949880117 no 2660 0.22658276589577 3852 729761 SGTC_1304 1165-0502 251 µM -0.750233911058115 0.218723444859513 no 2661 0.226556919180462 3775 767425 SGTC_700 3453-2283 142 µM -0.750450454264398 0.218656592532758 no 2662 0.226491726652206 3807 565664 SGTC_256 clotrimazole 625 nM -0.752169662582781 0.218126247290691 no 2663 0.225974517576222 3720 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1078 idebenone 36.1 µM -0.752410355597485 0.218052056978848 no 2664 0.225902160470568 3804 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_994 3910-0338 138 µM -0.75261868855523 0.217987852955591 no 2665 0.225839542020057 3844 3479481 SGTC_1809 st050081 57.6 µM -0.754304561423926 0.217468702001058 no 2666 0.225333181990541 3805 5036894 SGTC_3167 9103034 49.47 µM -0.756158130497733 0.216898734970704 no 2667 0.224777196331449 3780 5127859 SGTC_1350 1495-0454 146 µM -0.75691884717772 0.216665066987677 no 2668 0.224549241568112 3769 1069057 SGTC_2016 5121758 140 µM -0.757691396243141 0.216427913555933 no 2669 0.224317875433428 3745 2795203 SGTC_916 4466-0038 42 nM -0.75849049607623 0.216182767827271 no 2670 0.224078700218626 3847 5722064 YGL116W CDC20 SGTC_2279 7948423 32.93 µM -0.758554959508391 0.216162998917587 no 2671 0.224059412255633 3742 1247112 SGTC_2565 isoliquiritigenin 100 µM -0.759328912197656 0.215925733687725 no 2672 0.223827913205144 3807 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2999 9069765 71.4286 µM -0.761314079837365 0.215317845179464 no 2673 0.223234746398852 3803 2097066 SGTC_1473 k844-0725 134 µM -0.761403854282145 0.215290378369577 no 2674 0.223207943016578 3831 54682906 SGTC_2328 6201408 200 µM -0.762117317741586 0.215072163993125 no 2675 0.222994993934644 3786 2890418 SGTC_972 1319-0219 195 µM -0.763844699815559 0.214544372518896 no 2676 0.222479897726937 3748 23903702 SGTC_2211 7117706 200 µM -0.764112133210764 0.214462727174457 no 2677 0.222400211201892 3696 822771 SGTC_3189 9110682 49.47 µM -0.764925289830669 0.214214587760014 no 2678 0.222158016789503 3859 17122418 SGTC_958 1222-0007 33 µM -0.765121290421784 0.214154802046155 no 2679 0.222099661568969 3840 7312461 SGTC_1213 1315-0166 115 µM -0.765903479390794 0.213916309034524 no 2680 0.221866867739399 3839 768401 SGTC_172 1112-0046 2.638 µM -0.76593932209491 0.213905384135822 no 2681 0.22185620363145 3749 2802135 YIL048W NEO1 SGTC_2103 5378138 10 µM -0.766801015586596 0.213642836733699 no 2682 0.221599916232859 3807 244142 SGTC_3309 9129340 25.759 µM -0.767441581265269 0.2134477859663 no 2683 0.221409507007175 3827 17158987 SGTC_25 0118-0223 35.662 µM -0.768174922465666 0.2132246127477 no 2684 0.221191634997189 3795 5333628 SGTC_1839 st053978 48 µM -0.769106668721082 0.2129412565094 no 2685 0.22091499482755 3809 3788398 SGTC_3261 9137475 49.47 µM -0.769110498895422 0.212940092156912 no 2686 0.220913858038368 3684 17027690 SGTC_469 w7 172 µM -0.769279254220384 0.212888795129858 no 2687 0.220863775071288 3817 45115570 A P450 inhibitor. SGTC_2469 5655019 90.81 µM -0.77012337680853 0.212632313116346 no 2688 0.220613355166556 3849 2788239 SGTC_2121 5257820 149.641 µM -0.771326425067519 0.212267085539061 no 2689 0.220256736576111 3859 791256 SGTC_3182 9108849 49.47 µM -0.771423547005233 0.212237616765637 no 2690 0.220227961227749 3811 17133045 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.772951372439109 0.211774358206421 no 2691 0.219775579927242 3841 65057 A dermal irritant. YDR527W RBA50 SGTC_1952 st077036 64.1 µM -0.77369310841482 0.211549666760561 no 2692 0.219556148195773 3782 2937007 SGTC_2351 9026858 72.31 µM -0.773776964951337 0.211524273182349 no 2693 0.219531348386729 3732 1409300 SGTC_987 1497-1013 404 µM -0.774414485918584 0.211331276373527 no 2694 0.219342859974723 3780 1676435 SGTC_2892 9047358 58.44 µM -0.775334463597144 0.211052953308747 no 2695 0.219071024874247 3790 6466771 SGTC_721 1187-1332 279 µM -0.775577859145177 0.210979354224143 no 2696 0.218999138752367 3730 25730 SGTC_409 arachidonic acid 100 µM -0.775658399607302 0.210955003336066 no 2697 0.218975354363902 3797 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2002 4023503 131 µM -0.776468175255882 0.210710264488218 no 2698 0.218736302250679 3806 4736863 YCR052W RSC6 SGTC_376 3970-0862 59.1 µM -0.77779397865076 0.210309926145736 no 2699 0.218345239133161 3811 3135186 SGTC_53 0973-0023 39.979 µM -0.778086176354091 0.210221754503486 no 2700 0.218259105779206 3723 674768 SGTC_574 1315-0397 40 µM -0.778095968906168 0.210218799943905 no 2701 0.218256219492749 3819 6794277 SGTC_343 4130-2827 29.8 µM -0.778284445165094 0.21016193858659 no 2702 0.218200671714561 3871 1118244 SGTC_1193 1488-0126 41.5 µM -0.778944766526955 0.209962797675357 no 2703 0.218006125890256 3800 1384710 SGTC_3068 9116768 49.47 µM -0.779451559206937 0.209810033462503 no 2704 0.217856880990556 3751 41904888 SGTC_3254 9136651 49.47 µM -0.7796610337458 0.209746909941503 no 2705 0.217795210246411 3802 16454030 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.779774204770369 0.209712811380948 no 2706 0.217761896109126 3794 66535 A nucleotide analog. SGTC_177 1327-0068 8.361 µM -0.780494098849544 0.209495982787935 no 2707 0.217550049832825 3797 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2481 5478948 45.16 µM -0.780499925142725 0.209494228474977 no 2708 0.217548335790259 3827 77792 SGTC_3321 9137793 26.8275 µM -0.780595314119354 0.209465507819902 no 2709 0.217520274327691 3767 4904192 SGTC_2308 7584454 197.62 µM -0.782433756107077 0.208912424265014 no 2710 0.216979851053401 3822 893577 SGTC_1893 st059353 36.1 µM -0.783281583527414 0.208657650918643 no 2711 0.216730887754674 3841 3112488 SGTC_301 4119-0100 24.5 µM -0.785639002176894 0.207950206546783 no 2712 0.216039504084303 3831 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3350 9150499 3.57 µM -0.786430120561282 0.207713115345166 no 2713 0.215807771532723 3786 4910996 YPR165W RHO1 SGTC_1633 st005664 67.9 µM -0.787147633144229 0.20749822130814 no 2714 0.215597724058071 3824 2063822 SGTC_758 0868-0029 16 µM -0.787659101733614 0.207345117415314 no 2715 0.215448067118414 3879 762687 SGTC_136 0097-0015 404.482 µM -0.78803795906114 0.207231752680199 no 2716 0.215337251414007 3818 4861337 SGTC_1885 st057546 99.9 µM -0.789470337420214 0.206803476316876 no 2717 0.214918579994275 3886 702008 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.790858839533511 0.206388819361801 no 2718 0.214513184861921 3846 6728940 SGTC_1030 k029-0042 36.7 µM -0.792117715303716 0.206013299679371 no 2719 0.214146020738353 3823 6080581 SGTC_2181 6316240 54.2555 µM -0.792308431667479 0.205956444801807 no 2720 0.214090428254635 3832 12779990 SGTC_329 k048-0121 21.3 µM -0.793191151086844 0.205693416611352 no 2721 0.213833231151141 3824 6832902 SGTC_234 nsc-17383 10.7 µM -0.794988192324912 0.205158559978944 no 2722 0.213310185342456 3821 408974 SGTC_952 1185-0122 232 µM -0.795011475065268 0.205151635722358 no 2723 0.213303413579719 3767 678600 SGTC_51 1013-0126 23.419 µM -0.796319896244871 0.204762736205129 no 2724 0.212923062020108 3859 1627850 SGTC_2830 7992007 71.43 µM -0.796537099149608 0.204698219865205 no 2725 0.21285996053837 3732 1952075 SGTC_270 tamoxifen 5.46 µM -0.798223766354648 0.204197636419053 no 2726 0.212370323959983 3864 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_275 trichlorophene 5.69 µM -0.799415682780184 0.203844329355858 no 2727 0.212024709906002 3873 62616 SGTC_2654 protoveratrine a 100 µM -0.800125481880739 0.203634104386929 no 2728 0.211819049367115 3807 5702278 A heart drug and vasodilator. SGTC_840 0245-0196 390 µM -0.801157679518677 0.203328623738759 no 2729 0.21152018393334 3931 3827528 SGTC_1311 1190-0148 100 µM -0.802685902127984 0.202876846142107 no 2730 0.211078151703062 3894 1961333 SGTC_838 0109-0203 71.4 µM -0.802759155619292 0.202855205803096 no 2731 0.211056977033249 3840 759422 SGTC_720 r052-1644 49.9 µM -0.803304580862803 0.202694121182584 no 2732 0.210899355448766 3838 1422863 YOR257W CDC31 SGTC_1326 1431-2094 10.8 µM -0.804492850177699 0.202343445271884 no 2733 0.210556198457187 3817 616278 SGTC_2854 9024559 71.43 µM -0.804607001756479 0.202309776560017 no 2734 0.210523250199616 3875 3163529 SGTC_264 promethazine 12.5 mM -0.805915518106776 0.201924072461284 no 2735 0.210145781439471 3810 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1507 4075-3230 155 µM -0.806698891042653 0.201693372772858 no 2736 0.209919991594441 3747 659771 SGTC_3151 9099821 49.47 µM -0.807455674997038 0.201470653405374 no 2737 0.209702000893928 3788 17174189 SGTC_289 k017-0060 526 µM -0.809268029031406 0.20093788219052 no 2738 0.209180495911622 3832 5512909 SGTC_3165 9101544 49.47 µM -0.812595613313824 0.199961887663282 no 2739 0.208224973729573 3866 5002184 SGTC_647 0140-0236 81 µM -0.814262074140923 0.199474180744527 no 2740 0.20774741574934 3868 990837 SGTC_3173 9105693 49.47 µM -0.814306213508981 0.199461272645469 no 2741 0.207734775523985 3861 17096658 SGTC_2261 9010538 184.68 µM -0.814330846641441 0.199454069160724 no 2742 0.207727721512095 3844 6457250 SGTC_3008 9078912 71.4286 µM -0.815822042169284 0.199018289519654 no 2743 0.207300962245629 3839 16648731 SGTC_41 0478-0632 82.643 µM -0.816420078516762 0.198843683624358 no 2744 0.207129958373018 3790 3750424 SGTC_89 0302-0250 142.109 µM -0.816627213946349 0.198783228792054 no 2745 0.207070749058916 3923 4203518 YLR208W SEC13 SGTC_927 2425-1185 123 µM -0.818194811246074 0.198326067045041 no 2746 0.206622978751251 3829 730375 SGTC_2259 7964009 200 µM -0.818697289607235 0.198179662603741 no 2747 0.206479571703962 3905 313134 SGTC_2345 9052315 157.45 µM -0.820358789456499 0.19769602500404 no 2748 0.206005800590392 3906 6469265 SGTC_3030 9087619 49.47 µM -0.820605576257404 0.197624249971871 no 2749 0.205935485195071 3898 25236973 SGTC_2856 9022925 19.48 µM -0.821081020857031 0.197486016924477 no 2750 0.205800059925946 3904 4944862 SGTC_2916 7875993 68.79 µM -0.822080224825935 0.197195694166863 no 2751 0.205515619729901 3789 1299250 SGTC_548 1436-0017 110 µM -0.823007611683916 0.196926469347095 no 2752 0.205251832453399 3931 9677137 SGTC_1663 st014140 55.4 µM -0.823990390073363 0.196641407086472 no 2753 0.204972509178273 3932 4207120 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.825306939414172 0.196259924015576 no 2754 0.204598676545774 3955 688801 SGTC_962 1254-0300 21.5 µM -0.825831565657471 0.196108033530249 no 2755 0.204449822650044 3830 7340576 SGTC_2006 4011487 200 µM -0.825842368992178 0.196104906483827 no 2756 0.20444675806255 3922 45595294 SGTC_1296 1068-0102 11.9 µM -0.826237637232832 0.19599051611176 no 2757 0.204334650919763 3889 767053 SGTC_2702 st077768 96.8 µM -0.826262381450427 0.19598335649784 no 2758 0.204327634109355 3849 6484119 SGTC_1371 2421-0008 32.7 µM -0.827657223944333 0.195580022500454 no 2759 0.203932325415223 3869 2827552 SGTC_2072 5231554 129 µM -0.828449762080583 0.195351076124357 no 2760 0.203707917422555 3918 789545 SGTC_3149 9097855 49.47 µM -0.830732175535008 0.194692648579399 no 2761 0.203062472742238 3886 25236625 YMR079W SEC14 SGTC_2497 7-hydroxyflavone 100 µM -0.830810721400331 0.194670013831943 no 2762 0.203040282479157 3886 5281894 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.832353676401785 0.194225701549931 no 2763 0.202604670605721 3843 15053 SGTC_1896 st058441 89 µM -0.833684612520903 0.193842939198694 no 2764 0.202229365684329 3907 688759 SGTC_1157 4092-0394 27.6 µM -0.836867785939531 0.19292936070943 no 2765 0.201333444824295 3989 3659885 SGTC_367 0335-0881 7.1 µM -0.837772956056938 0.19267005568095 no 2766 0.201079115073678 3879 23828853 SGTC_2730 imipramine 71.33 µM -0.837794199402957 0.192663972636406 no 2767 0.20107314854962 3883 3696 A tricyclic antidepressant. SGTC_1116 jasmonic acid  1.58368 µM -0.84008154672134 0.192009676232549 no 2768 0.20043133292482 3947 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3014 9081533 49.47 µM -0.841376121335487 0.191639966118167 no 2769 0.200068629170588 3929 21367265 SGTC_2536 dehydroabietamide 32.04 µM -0.841965635900123 0.191471754622989 no 2770 0.199903594437543 3964 3983547 SGTC_225 nsc-122657 1.016 µM -0.842497245347169 0.191320143313945 no 2771 0.19975484047824 3897 275685 SGTC_3239 9133757 49.47 µM -0.845565358866505 0.190446577244354 no 2772 0.198897628619816 3901 17036923 SGTC_2680 butyl paraben 22.24 µM -0.846087745028088 0.190298085672868 no 2773 0.198751898375199 3952 7184 An antifungal and steroid mimetic. SGTC_2210 7115885 190.385 µM -0.848580069389398 0.189590606279652 no 2774 0.198057500536322 3946 2927039 SGTC_2132 5317594 122.667 µM -0.849087012781126 0.189446901950802 no 2775 0.197916438239036 3873 794577 SGTC_2253 7938677 135.83 µM -0.849365481125627 0.189367992464589 no 2776 0.197838977342727 3983 2301972 SGTC_2411 st077133 39.94 µM -0.84973562304948 0.189263136787523 no 2777 0.197736044176606 4017 1403142 YNL221C POP1 SGTC_1530 rhein 70.4 µM -0.850586078723483 0.189022350851865 no 2778 0.197499662679 3955 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_966 1300-0360 30.2 µM -0.851208879078903 0.188846139752928 no 2779 0.197326665685942 3892 70588 SGTC_488 nitrendipine 139 µM -0.853289955695696 0.188258067992876 no 2780 0.196749264381897 3946 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1337 1486-1011 40.3 µM -0.853950680714245 0.188071596521847 no 2781 0.196566158352058 3890 X1337 SGTC_1301 naphtanilide LB 4.81 µM -0.856228672252 0.187429570594841 no 2782 0.195935652989581 3977 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3155 9099265 49.47 µM -0.857529289028367 0.187063614863912 no 2783 0.195576217567427 3946 25236499 SGTC_1516 st013856 110 µM -0.859516773421476 0.186505249005411 no 2784 0.195027734987398 3982 5281404 A mutagen and neurotoxin. SGTC_568 1193-0097 7.48 µM -0.860658941993287 0.186184834559425 no 2785 0.194712956278181 3784 3646150 SGTC_3213 9129884 49.47 µM -0.860953383489759 0.186102289738686 no 2786 0.194631859099646 3925 17190742 SGTC_5 0352-0601 109.883 µM -0.861414344831084 0.185973107691026 no 2787 0.194504939118045 3838 762456 SGTC_2786 7743617 45.45 µM -0.861425633865881 0.185969944694663 no 2788 0.194501831454568 3865 583674 SGTC_2449 5812982 45.77 µM -0.861907424137222 0.185834986309357 no 2789 0.194369231629519 3893 776185 SGTC_406 estrone 100 µM -0.865167948848447 0.184923250218931 no 2790 0.193473307169035 3886 5870 A steroid. SGTC_2868 9035608 32.47 µM -0.866066830505428 0.184672386777058 no 2791 0.193226756848439 3887 6462614 SGTC_29 0299-0004 12.984 µM -0.868412653780456 0.184018702406496 no 2792 0.192584235064718 3814 16871 A napthoquinone isolated from Swertia calycina. SGTC_1042 0350-0096 82 µM -0.8691145812374 0.183823384493364 no 2793 0.192392231025153 3920 3122515 SGTC_1506 4226-2149 212 µM -0.869784073805432 0.183637212256984 no 2794 0.192209208275535 3955 991114 SGTC_851 0394-0702 453 µM -0.871950872930649 0.183035475450731 no 2795 0.191617589396878 3891 762646 SGTC_1448 4255-0083 152 µM -0.872766062334232 0.182809409912134 no 2796 0.191395300628423 4002 5399660 SGTC_2762 leflunomide 42.06 µM -0.873696023312338 0.182551729235765 no 2797 0.191141908587714 3905 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3238 9133470 49.47 µM -0.873898983974412 0.182495521519871 no 2798 0.191086634036637 3922 3534688 SGTC_3127 9126946 49.47 µM -0.874701623636647 0.182273345244175 no 2799 0.190868138229805 3939 27243249 SGTC_1550 gossypolone 36.6 µM -0.875108426765482 0.182160803864547 no 2800 0.190757456208307 3942 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2094 5332512 191.667 µM -0.876560381252292 0.181759477448886 no 2801 0.190362733172246 3984 755774 SGTC_759 3486-0358 89.3 µM -0.87783134761944 0.181408631306102 no 2802 0.190017624980165 3904 875103 SGTC_541 4513-1321 94 µM -0.878241384113081 0.181295532580328 no 2803 0.189906368997105 3940 747515 SGTC_515 4092-1064 102 µM -0.878486654456012 0.181227901752865 no 2804 0.189839838474176 3948 717353 SGTC_1354 1498-1681 81 µM -0.880015361805345 0.18080673232686 no 2805 0.189425493845227 3959 5754243 SGTC_1481 3346-2004 36 µM -0.880879947701302 0.180568804801734 no 2806 0.189191400936425 3971 2770522 SGTC_1653 st012112 65 µM -0.881691931912049 0.180345531757438 no 2807 0.188971712597243 3924 720429 SGTC_2970 9090938 41.86 µM -0.882049047742247 0.180247389720587 no 2808 0.18887514204344 4019 17217104 SGTC_2447 5741742 33.78 µM -0.882076161909588 0.180239939615091 no 2809 0.188867811126379 4000 1776504 SGTC_2767 sibutramine 71.45 µM -0.885144731146571 0.179398043803609 no 2810 0.188039288326846 3930 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3236 9132701 49.47 µM -0.887035457223426 0.178880535319462 no 2811 0.187529905520502 3953 24282524 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.887770821093514 0.178679513748254 no 2812 0.187332020781613 3966 23665772 A membrane-active detergent. SGTC_3268 9137683 49.47 µM -0.89180795575964 0.177578444419206 no 2813 0.18624793834706 3976 1953228 SGTC_2091 4-phenylthiadiazole 200 µM -0.893252369321414 0.177185544099259 no 2814 0.185861019457965 3943 270010 SGTC_389 tpck 16.7 µM -0.894016713272206 0.176977854376423 no 2815 0.185656474457915 3974 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1865 st057639 52.2 µM -0.895282546508474 0.176634237040232 no 2816 0.185318033944026 3935 688818 SGTC_2387 9077560 195.08 µM -0.896298146327731 0.176358852164171 no 2817 0.185046774435748 3935 5303272 SGTC_3001 9076041 71.4286 µM -0.896800791380062 0.176222658037896 no 2818 0.184912612808136 3955 16004211 SGTC_805 3852-0218 479 µM -0.89736401787366 0.1760701281791 no 2819 0.184762353144439 3907 6615355 SGTC_967 1306-0166 352 µM -0.898587373118909 0.175739113961889 no 2820 0.184436243439252 3916 4437607 SGTC_1208 2323-2347 50.3 µM -0.899981766610372 0.175362301499272 no 2821 0.184064977022603 3982 5412760 SGTC_642 0335-0876 158 µM -0.901549059942559 0.174939377568879 no 2822 0.183648230698613 4004 6812350 SGTC_1327 1436-0082 2.18 µM -0.902062783865599 0.174800893463718 no 2823 0.183511758555942 3965 15992205 SGTC_3352 9151559 45.5865 µM -0.902223963889967 0.174757458651264 no 2824 0.183468953679264 3971 17159339 SGTC_542 3381-0244 89.3 µM -0.90230127660261 0.174736626843636 no 2825 0.183448423808226 4007 1112843 SGTC_2925 9010536 32.5 µM -0.903448810904749 0.174427610616638 no 2826 0.183143872181476 3935 2994177 SGTC_3294 9122953 26.2835 µM -0.905054325323608 0.173995849229601 no 2827 0.182718303864356 3979 16459826 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.905188789180882 0.173959719532244 no 2828 0.182682690021956 4015 521171 SGTC_506 n9-isopropylolomoucine 153 µM -0.907754779149718 0.173271166424331 no 2829 0.18200389750726 3989 6610355 SGTC_661 1304-0007 33.6 µM -0.907830188966416 0.173250957374368 no 2830 0.181983972903634 3982 3117130 SGTC_936 3005-4620 401 µM -0.917155834417281 0.170763355282227 no 2831 0.179530493228362 4012 777207 SGTC_171 k064-0041 9.68 µM -0.917546559160305 0.170659631429749 no 2832 0.179428153475685 4007 53325 SGTC_2790 5423970 71.43 µM -0.921930769980146 0.169498541871801 no 2833 0.178282343974895 4082 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3241 9133421 49.47 µM -0.923992116807066 0.16895438248089 no 2834 0.177745210094479 4008 17018221 SGTC_2376 9072922 81.32 µM -0.924667212439488 0.16877641329238 no 2835 0.177569519729096 4041 17087968 SGTC_724 3910-0327 137 µM -0.927364194886913 0.168066635303105 no 2836 0.17686873713871 4054 2885483 SGTC_1931 st074438 57.1 µM -0.929947735750702 0.167388516340071 no 2837 0.176199072771513 3972 2787313 SGTC_2818 7996756 12.99 µM -0.930574245757887 0.167224338127621 no 2838 0.176036920886711 4009 2241621 SGTC_2904 7225135 42.03 µM -0.930839757222359 0.167154791639459 no 2839 0.175968230330505 4111 4446116 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.932394803338949 0.166747846629077 no 2840 0.175566264713078 4037 5357218 A potent inhibitor of glutathione S-transferases. SGTC_478 N-arachidonylglycine 10 µM -0.93342881653486 0.166477606546144 no 2841 0.175299303853197 3950 5283389 SGTC_3021 9087658 49.47 µM -0.936306642272805 0.165726974169831 no 2842 0.174557664614679 3980 25237042 SGTC_2136 5328288 199.296 µM -0.938098572536108 0.165260686577628 no 2843 0.174096877676015 4016 262395 SGTC_834 0312-0008 75.7 µM -0.939406226037855 0.164920951568235 no 2844 0.173761108813268 4011 6385573 YIL048W NEO1 SGTC_519 k048-0011 62.8 µM -0.941541593320517 0.164367145364782 no 2845 0.173213692390438 4077 6836379 SGTC_2811 7967822 32.47 µM -0.944042954898433 0.163719953917422 no 2846 0.172573849094981 4089 2232244 SGTC_3324 9138759 60.749 µM -0.94478568221058 0.163528102823617 no 2847 0.17238415149411 4061 45595710 SGTC_147 4466-0538 29.23 µM -0.945817374566553 0.163261852603086 no 2848 0.17212087105586 4116 6742687 YHR072W ERG7 SGTC_476 mead acid 10 µM -0.945993322255807 0.163216473677951 no 2849 0.172075996105829 4031 5312531 An omega 9 fatty acid. SGTC_1673 st016611 27.3 µM -0.94626495256389 0.163146433204195 no 2850 0.17200673224548 4056 5226799 SGTC_403 arphamenine a 50 µM -0.946596087746481 0.163061075691821 no 2851 0.171922319128819 3992 5487158 An arginine aminopeptidase inhibitor. SGTC_3246 9135460 32.98 µM -0.947369873188713 0.162861728348384 no 2852 0.171725168566943 3973 41446951 SGTC_2883 9059145 45.46 µM -0.949060221380831 0.162426801958687 no 2853 0.171294992155222 4002 16476510 SGTC_2928 9011484 9.79 µM -0.949255061571534 0.162376718232605 no 2854 0.171245451629297 4059 2994751 SGTC_741 4582-0002 126 µM -0.949581779017695 0.162292757982517 no 2855 0.171162400243991 3995 2912688 SGTC_3186 9110464 49.47 µM -0.951055733156904 0.161914330859525 no 2856 0.170788042248025 4041 17018021 SGTC_2873 9040596 71.43 µM -0.951211083437927 0.161874479306639 no 2857 0.17074861660151 4029 6463863 SGTC_2099 5377090 177.372 µM -0.952663138119686 0.161502297025072 no 2858 0.170380387912971 4054 2243829 SGTC_1123 mangostin 811.285 nM -0.955102224660212 0.160878381175929 no 2859 0.169763002034588 4053 5281650 An antioxidant. SGTC_2061 5245884 80.95 µM -0.957137269618448 0.160359024466145 no 2860 0.169248987184283 4002 573863 SGTC_2666 tannic acid 100 µM -0.957718030679875 0.16021101164271 no 2861 0.169102481089347 4046 16134267 A thiamine antagonist. SGTC_546 peri-Naphthalide 147 µM -0.957852993392317 0.160176627824086 no 2862 0.169068446291771 3950 223824 A penicillin ester. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.959833178078258 0.159672700105794 no 2863 0.168569590620912 4083 5282362 SGTC_1999 st074831 12.5 µM -0.96224661767685 0.1590599196928 no 2864 0.167962868537263 4004 17112523 SGTC_1424 4048-1941 275 µM -0.962318691430833 0.159041643648926 no 2865 0.167944771332946 4106 X1424 SGTC_1816 st051957 91.6 µM -0.963286377883048 0.158796396589359 no 2866 0.167701913742164 4029 674121 SGTC_1510 1123-0200 71.5 µM -0.965027536033843 0.158355748204698 no 2867 0.167265509963005 4126 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2467 5474540 200 µM -0.965318462327814 0.158282199526453 no 2868 0.167192663647336 4008 5413519 SGTC_2794 7785382 27.27 µM -0.966607791134334 0.157956515904609 no 2869 0.166870069140428 3999 2205081 SGTC_1243 0416-0003 5.65 µM -0.966822750355793 0.157902260168117 no 2870 0.166816324679895 4054 2141977 SGTC_976 1348-1067 47.6 µM -0.967579032483327 0.157711471733184 no 2871 0.166627326539807 4068 5310671 YGL099W LSG1 SGTC_1548 st061468 90.8 µM -0.969664158923233 0.157186238352359 no 2872 0.166106960580051 4038 390799 SGTC_281 1672-3440 14.9 µM -0.973251925002542 0.156285192541649 no 2873 0.165214054770636 4103 6833000 SGTC_3178 9107506 49.47 µM -0.973296222048859 0.156274088911336 no 2874 0.165203049786692 4082 8897194 SGTC_1573 oleylamine 1.06 µM -0.973442344104278 0.156237465203787 no 2875 0.165166751161952 4054 5356789 An amine of the fatty acid oleic acid. SGTC_2236 dapsone 200 µM -0.976143503624046 0.155561471002611 no 2876 0.164496677773744 4056 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_591 4299-0174 154 µM -0.977969133947227 0.15510568168754 no 2877 0.164044795122761 4065 5509088 SGTC_2082 5219693 150 µM -0.97876358201113 0.15490761432495 no 2878 0.163848403897945 4059 2834649 SGTC_1996 st072960 66.8 µM -0.979235724999299 0.15478998144539 no 2879 0.1637317602916 4107 1719405 SGTC_1220 1838-0075 193 µM -0.980153732056691 0.154561431956519 no 2880 0.163505119655264 3965 5529645 SGTC_390 dec-rvkr-cmk 16.7 µM -0.981094832324613 0.154327364760627 no 2881 0.163272989283168 4098 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1692 fluoroquinolonic acid 71 µM -0.981777229677853 0.154157787929534 no 2882 0.163104804169112 4112 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2083 5306046 65.942 µM -0.983626952298553 0.153698748964409 no 2883 0.16264948404813 4085 539837 SGTC_1904 st060225 78 µM -0.983801579638739 0.153655459127238 no 2884 0.162606541256318 4011 66595 SGTC_1097 itavastatin 7.23 µM -0.985863298150838 0.153144972753873 no 2885 0.16210009959436 4074 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1956 st077085 54 µM -0.988540568399645 0.152483753678171 no 2886 0.161443988174935 4117 24208685 SGTC_1631 benzylvanillin 81.9 µM -0.990867877699709 0.151910507715235 no 2887 0.160875049694221 4158 75506 SGTC_2041 5107442 45.335 µM -0.992970631434502 0.151393805347035 no 2888 0.160362133418295 4127 793005 SGTC_1655 st012546 55.1 µM -0.993010429971955 0.15138403707354 no 2889 0.160352435836704 4072 720985 YLR208W SEC13 SGTC_697 0508-1955 564 µM -0.993746417464016 0.151203469620756 no 2890 0.160173169207848 4082 6243113 SGTC_2738 aclarubicin 5.55 µM -0.993771496422062 0.151197319264925 no 2891 0.160167062961711 4040 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2160 5660466 132.927 µM -0.998141419253398 0.150128181547925 no 2892 0.159105393983495 3970 2859134 SGTC_2595 hexamethylquercetagetin 100 µM -0.999472114784838 0.149803619305865 no 2893 0.158783020413551 4069 386331 SGTC_180 1486-1293 102.781 µM -1.00170823843268 0.149259274134777 no 2894 0.158242263284869 3972 4140536 SGTC_3011 9081274 71.4286 µM -1.00196166927285 0.149197664263332 no 2895 0.158181052965317 4088 6625322 SGTC_1394 3474-0001 65.7 µM -1.0023171472168 0.149111275025854 no 2896 0.158095221731134 4083 5017666 YIL048W NEO1 SGTC_3220 9131269 49.47 µM -1.00292334601155 0.148964031991536 no 2897 0.157948923712636 4105 17722206 SGTC_3033 9090887 49.47 µM -1.00314520334135 0.148910168106718 no 2898 0.157895403622209 4121 19325384 SGTC_659 k018-0002 107 µM -1.0036575260673 0.148785832979385 no 2899 0.157771858176711 4111 6797879 YHR007C ERG11 SGTC_1534 6-azauridine 81.6 µM -1.0044088197687 0.148603627717618 no 2900 0.157590800286317 4113 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2148 5546263 113.568 µM -1.01314253365504 0.146496458444952 no 2901 0.155496042281709 4087 792097 SGTC_1801 st050089 28.441 µM -1.0158111044684 0.145856636567876 no 2902 0.154859673526294 4142 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1944 st076371 56.9 µM -1.01716569209151 0.145532577599023 no 2903 0.154537306900513 4078 24208455 SGTC_248 streptozotocin 5.23457 mM -1.01994799746127 0.144868484282906 no 2904 0.1538765621633 4133 5300 DNA alkylating agent. SGTC_3212 9128307 49.47 µM -1.02040005427202 0.144760778302718 no 2905 0.153769384077413 4068 27243542 SGTC_2948 9070189 9.45 µM -1.02212523665027 0.144350236162756 no 2906 0.15336081507074 4058 6473636 YDL196W YDL196W SGTC_774 k060-0086 136 µM -1.02431539762749 0.143830174431337 no 2907 0.152843163748164 4115 5911235 SGTC_1953 st076800 12.1 µM -1.02537027268917 0.143580142074437 no 2908 0.15259425467427 4123 297591 SGTC_2047 4141938 200 µM -1.02612063562009 0.143402465545942 no 2909 0.152417362281538 4102 3807862 SGTC_1559 coumarin 343 70.1 µM -1.02768397649164 0.143032763063884 no 2910 0.152049253795439 4148 108770 A hepatotoxic, DNA x-linker. SGTC_1509 1326-1131 80 µM -1.02855913461711 0.142826085037892 no 2911 0.151843444685794 4086 768313 SGTC_948 3448-0295 75.3 µM -1.02856942392788 0.142823656307437 no 2912 0.15184102607144 4108 678569 SGTC_2475 5812728 15.03 µM -1.03005164688396 0.142474078060609 no 2913 0.151492880876244 4065 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1233 0325-0408 14.2 µM -1.03010813423534 0.142460767130379 no 2914 0.151479623608382 4164 12874 SGTC_1019 4262-0212 3.4 µM -1.03137167567512 0.142163240456431 no 2915 0.151183279052049 4141 4677213 SGTC_3006 9075424 71.4286 µM -1.03156180553942 0.14211850691799 no 2916 0.151138720371551 4075 7465181 SGTC_2429 5902844 64.44 µM -1.03160323030108 0.142108761811245 no 2917 0.151129013257433 4132 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1445 4239-0156 97.7 µM -1.03347407774552 0.141669119469296 no 2918 0.150691047719634 4203 4008346 SGTC_1725 st036284 20.55 µM -1.03434193485882 0.1414654893629 no 2919 0.150488169545534 4207 707914 SGTC_1442 4112-3290 3 µM -1.03605474569688 0.141064185356392 no 2920 0.150088301447171 4102 704353 SGTC_1792 st045773 43.6 µM -1.03752279469631 0.140720842959672 no 2921 0.149746139011127 4081 2919270 SGTC_1074 carmofur 3.8 µM -1.0390008505068 0.140375733554206 no 2922 0.149402170357731 4167 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_206 4546-0025 72.014 µM -1.0398240434121 0.140183776650391 no 2923 0.149210828259215 4183 6620745 YIL048W NEO1 SGTC_1156 4092-0367 4.88 µM -1.04184801777034 0.139712572978923 no 2924 0.148741073851571 4148 1357585 SGTC_763 3453-1109 128 µM -1.04455394110544 0.139084287985176 no 2925 0.14811458822675 4150 1560353 SGTC_2214 7179297 48.276 µM -1.04540069292755 0.138888077404509 no 2926 0.147918908296286 4162 769744 SGTC_709 3807-1509 243 µM -1.04706498175923 0.138502975463555 no 2927 0.147534804397482 4207 1886677 YPL242C IQG1 SGTC_1219 1469-0211 33.1 µM -1.05177440521176 0.137417201182048 no 2928 0.146451532273476 4176 6822282 SGTC_2744 captopril 92.04 µM -1.0544725561548 0.136797758486366 no 2929 0.145833309449809 4180 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2686 alizarin 95.37 µM -1.05493325365883 0.136692182428488 no 2930 0.145727926167344 4138 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2482 5981709 142.65 µM -1.05701244689596 0.136216395857513 no 2931 0.145252953439201 4095 877755 SGTC_776 4476-4378 112 µM -1.05783121884368 0.136029345768616 no 2932 0.14506619862608 4204 2892008 SGTC_392 N-ethylmaleimide 8.33 µM -1.06098697863318 0.135310051457551 no 2933 0.144347909432117 4089 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2997 9067075 71.4286 µM -1.06210265921964 0.135056378606501 no 2934 0.144094541512219 4166 27209819 SGTC_792 4534-1957 155 µM -1.06254147756825 0.134956693683273 no 2935 0.143994969320871 4088 1717904 SGTC_351 caspofungin 25 nM -1.06680828363005 0.133990048367206 no 2936 0.1430292086036 4161 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_589 1227-0070 34.1 µM -1.06712584121742 0.133918296365639 no 2937 0.142957507130648 4231 2841384 SGTC_485 niflumic acid 177 µM -1.07133102108596 0.132970627548816 no 2938 0.142010308138815 4220 4488 A COX2 inhibitor. SGTC_2944 9067346 25.62 µM -1.0713723124011 0.13296134518788 no 2939 0.142001028557206 4120 6473075 SGTC_2171 5739187 198.077 µM -1.07415472245221 0.13233688211656 no 2940 0.141376670827262 4102 2262761 SGTC_197 4544-0043 41.561 µM -1.07547224296089 0.132041894097364 no 2941 0.141081676444885 4152 896523 SGTC_733 4069-0007 56.1 µM -1.07612732764909 0.131895391940649 no 2942 0.140935157695441 4169 5717425 YNL287W SEC21 SGTC_2770 toltrazuril 17.5 µM -1.07626137890759 0.131865426743253 no 2943 0.140905188004266 4093 68591 Kills coccidiodes. SGTC_2329 6138490 200 µM -1.07641756534685 0.131830519473938 no 2944 0.140870275028642 4278 720019 SGTC_526 4469-0568 170 µM -1.07652981330664 0.131805436279709 no 2945 0.140845187420723 4116 2901964 SGTC_1675 st018485 24.5 µM -1.0797667955733 0.131083508892475 no 2946 0.140123020409159 4210 3323024 SGTC_2939 9044578 71.43 µM -1.08160531543704 0.130674691881692 no 2947 0.139713970809127 4107 2653634 SGTC_152 4469-0003 551.229 µM -1.08759232919737 0.129349520014231 no 2948 0.138387559306 4119 697280 SGTC_518 1021-0119 62.6 µM -1.08821095862366 0.129213124712421 no 2949 0.138250994003802 4154 1097762 SGTC_2951 9072950 58.06 µM -1.08969733937611 0.128885815410156 no 2950 0.137923244262456 4150 16488155 SGTC_2825 7998094 58.44 µM -1.08970408948163 0.128884330312317 no 2951 0.137921757061529 4185 2987815 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.09211804392733 0.128353994586624 no 2952 0.137390609664904 4120 4330530 SGTC_292 k038-0015 474 µM -1.09325489803252 0.128104757984543 no 2953 0.137140949716579 4184 46368540 SGTC_856 0433-0016 11.3 µM -1.09997266961958 0.126638859569449 no 2954 0.135672015018755 4229 3911780 SGTC_2180 6301957 200 µM -1.10150448264304 0.126306241728896 no 2955 0.135338577307022 4213 845462 SGTC_1066 ketoconazole 628 nM -1.10202719852857 0.126192878659184 no 2956 0.13522492366883 4261 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2938 9059746 27.26 µM -1.10321223581391 0.125936138516533 no 2957 0.134967504470859 4203 6471769 SGTC_679 0422-0091 41.4 µM -1.10327262518063 0.125923064828787 no 2958 0.134954395424175 4208 627384 YHR062C RPP1 SGTC_162 k030-0015 37.8 µM -1.10352505530497 0.125868426504167 no 2959 0.134899608506212 4266 1809920 YMR134W ERG29 SGTC_2813 7971799 71.43 µM -1.10482626661565 0.125587042515328 no 2960 0.134617438309255 4224 2234054 SGTC_126 0417-1624 672.48 µM -1.10855784968135 0.124782531552733 no 2961 0.133810485025014 4250 41912 YDL195W SEC31 SGTC_21 0849-0113 22.993 µM -1.10931592201524 0.12461953599357 no 2962 0.133646959389157 4163 1560156 SGTC_3184 9108758 49.47 µM -1.10934221625633 0.124613885056454 no 2963 0.133641289860866 4225 902885 SGTC_3314 9135860 59.4275 µM -1.11822750260903 0.122714581928376 no 2964 0.131734920468863 4194 25252478 SGTC_2425 5628681 7.85 µM -1.11995226963528 0.122348264601447 no 2965 0.131367051182649 4293 5714958 SGTC_2670 beta-carotene 100 µM -1.11995477634914 0.122347732768268 no 2966 0.131366517051463 4151 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2359 9039622 200 µM -1.12191756001971 0.121931799669624 no 2967 0.130948746840794 4170 6463596 SGTC_3040 9091894 49.47 µM -1.12333740138784 0.121631541125712 no 2968 0.130647112440121 4062 25236966 SGTC_486 niguldipine 82 µM -1.12445369105123 0.121395840810456 no 2969 0.130410302815827 4273 1236 A calcium channel blocker. SGTC_550 4123-0385 25.7 µM -1.12703944842239 0.120851101957241 no 2970 0.129862901279842 4247 5731123 SGTC_1168 k815-0004 80.5 µM -1.13068292718679 0.120086457352445 no 2971 0.129094284863542 4195 642433 SGTC_1375 2910-0797 186 µM -1.13281861982118 0.119639835015683 no 2972 0.128645215255184 4234 742508 SGTC_3152 9099253 49.47 µM -1.13427511273749 0.119335921644213 no 2973 0.128339582585242 4138 25236131 SGTC_553 k007-0256 45.7 µM -1.1344471999536 0.119300049760924 no 2974 0.128303504873574 4287 6287000 SGTC_2306 7482397 179.52 µM -1.13605949060259 0.118964334549156 no 2975 0.127965833677527 4241 891448 SGTC_1853 st056710 91.2 µM -1.1371532573299 0.11873696782423 no 2976 0.127737111701433 4285 269167 SGTC_1620 st003704 16.5 µM -1.13904477317664 0.118344493855477 no 2977 0.127342240101553 4218 2834414 SGTC_561 1550-0330 72.9 µM -1.13922222147207 0.118307721903852 no 2978 0.127305239721736 4166 6812934 SGTC_2235 salicylic acid 500 µM -1.13931388915362 0.118288729115094 no 2979 0.127286128694773 4249 338 A COX inhibitor and kinase inhibitor. SGTC_1949 st076024 69.1 µM -1.14221869855031 0.11768799270897 no 2980 0.126681562746831 4159 2921930 SGTC_2911 7942208 15.64 µM -1.14399543374383 0.117321616555438 no 2981 0.12631276535375 4271 1243384 SGTC_1293 1000-1278 195 µM -1.14406177224932 0.117307952717902 no 2982 0.126299009956837 4272 678847 SGTC_2581 avocatin a 64 µM -1.14780194074531 0.11653940718677 no 2983 0.125525167985569 4202 6710728 A skin care supplement. SGTC_3055 9094636 49.47 µM -1.14943704505819 0.116204543362039 no 2984 0.125187906006652 4273 25236176 SGTC_762 1165-0429 115 µM -1.15580335900274 0.114907250345174 no 2985 0.123880799396372 4257 5967793 SGTC_117 lucigenin 22.078 µM -1.15583162251333 0.11490151402158 no 2986 0.123875017822017 4247 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_364 0083-0097 67.7 µM -1.15951234250115 0.114156219836204 no 2987 0.123123704245296 4300 5207356 SGTC_121 0557-0495 61.343 µM -1.16201424714168 0.113651588868441 no 2988 0.122614838906566 4336 3104427 SGTC_278 4092-0821 23.9 µM -1.16287115192824 0.113479118419648 no 2989 0.122440891711895 4243 877900 SGTC_402 epigallocatechin gallate 10 µM -1.16303799646555 0.11344555910092 no 2990 0.122407043293954 4191 65064 An antioxidant. SGTC_2495 cafestol 54.53 µM -1.16525908593453 0.112999480515922 no 2991 0.121957067525648 4272 16667697 An anti-infammatory. SGTC_1285 0929-0069 65.5 µM -1.1662700306571 0.112796859770527 no 2992 0.12175264306515 4278 1206237 SGTC_455 paf C-16 10 µM -1.17445945014998 0.111165035411334 no 2993 0.120105522415644 4227 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_768 0384-0033 77.3 µM -1.17504525426235 0.1110489592342 no 2994 0.119988305595645 4218 3965305 YMR134W ERG29 SGTC_1860 st056228 74.6 µM -1.18154979191188 0.109765925022696 no 2995 0.118692192760519 4251 688679 SGTC_1436 4092-1007 8.32 µM -1.18606263862987 0.108882030742153 no 2996 0.117798781811356 4259 2881121 SGTC_237 nikkomycin 200 µM -1.18811945241197 0.108480881532032 no 2997 0.117393175780793 4285 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1433 4060-0023 7.6 µM -1.18881746279343 0.10834498752364 no 2998 0.117255752361188 4302 3840627 SGTC_2374 9071832 200 µM -1.19223564619111 0.107681278120994 no 2999 0.116584429993623 4203 17381698 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.19338690361741 0.107458399009028 no 3000 0.116358940817222 4318 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2727 riluzole 51.77 µM -1.19442803144128 0.107257127045754 no 3001 0.11615528858073 4327 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_195 4234-0266 16.654 µM -1.1971381118849 0.106734486289158 no 3002 0.115626363594655 4296 2303354 SGTC_3015 9080845 49.47 µM -1.19863444437279 0.10644670633758 no 3003 0.115335059382181 4319 5296973 SGTC_1814 st052110 31.539 µM -1.19964495421817 0.106252678695076 no 3004 0.115138629849223 4222 674163 SGTC_2940 9060638 45.86 µM -1.20167395214963 0.105863863161085 no 3005 0.114744938469714 4278 4027022 SGTC_1959 st077091 55.8 µM -1.20205573746508 0.105790816994885 no 3006 0.114670966934045 4289 821356 YKL052C ASK1 SGTC_866 0495-0101 262 µM -1.20228178067088 0.105747585807811 no 3007 0.114627186685806 4276 635694 SGTC_1843 st055809 45.5 µM -1.20269673199689 0.105668258832002 no 3008 0.114546849508753 4352 16413835 SGTC_1736 st036774 51 µM -1.20313575181709 0.105584377489803 no 3009 0.114461896158231 4340 1272247 SGTC_2591 skatole 100 µM -1.20336828390731 0.105539968245877 no 3010 0.114416917775234 4313 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3059 1327-0034 3 µM -1.20414648397152 0.105391444960602 no 3011 0.114266483060415 4146 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_23 0213-0011 39.996 µM -1.20553459774202 0.10512689214808 no 3012 0.113998495049657 4291 627608 SGTC_986 1493-0483 84 µM -1.20676243043469 0.104893287254889 no 3013 0.1137618242293 4232 40079 SGTC_2117 5521686 200 µM -1.21127728099345 0.104037533221662 no 3014 0.112894576454818 4267 803312 SGTC_1024 4507-0395 26 µM -1.21333556201853 0.103649086836663 no 3015 0.11250077589827 4344 4201836 SGTC_984 1492-0255 2.91 µM -1.21499533671613 0.103336615323965 no 3016 0.112183934984117 4274 1585198 SGTC_2878 9043973 25.97 µM -1.21742234771125 0.10288093482857 no 3017 0.111721782288483 4324 6465167 SGTC_2506 ethyl hematommate 54.16 µM -1.21804468781778 0.102764323654047 no 3018 0.111603495657778 4359 3940691 An allergen. SGTC_2646 retinol 96.75 µM -1.21941303404448 0.10250826717843 no 3019 0.111343732666758 4316 445354 A vitamin A analog and teratogen. SGTC_2135 5326629 150.42 µM -1.22228870098752 0.101971660542933 no 3020 0.11079923529147 4248 5020077 SGTC_438 sphingosine 6.67 µM -1.22234072467394 0.101961971654018 no 3021 0.110789402390927 4233 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3048 9093155 49.47 µM -1.22327147908385 0.101788741196199 no 3022 0.110613587874735 4276 25236002 SGTC_361 000s-0510 1.45 µM -1.22342545685482 0.101760103776173 no 3023 0.110584521587804 4223 660 SGTC_1502 4534-4282 27.7 µM -1.22419569921331 0.10161693898176 no 3024 0.110439205609785 4260 3278949 SGTC_186 3455-3465 67.277 µM -1.2266969000538 0.101153052788902 no 3025 0.109968266638648 4317 755278 SGTC_1012 4112-3522 18 µM -1.22995761006078 0.100550623873214 no 3026 0.109356489530602 4326 3112398 SGTC_2810 7959871 45.46 µM -1.2303636046679 0.100475798409143 no 3027 0.109280487976642 4278 2974535 SGTC_483 fpl-64176 144 µM -1.23073444029948 0.100407488310607 no 3028 0.109211101294839 4430 3423 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.23174136429186 0.100222177955684 no 3029 0.109022856444067 4275 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1606 st000094 49.2 µM -1.23352016154373 0.0998954253400158 no 3030 0.108690879689491 4337 1242210 SGTC_491 tetrandrine 80.3 µM -1.23393006885452 0.099820238665082 no 3031 0.108614481904506 4303 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2323 6148992 148.28 µM -1.23475465944834 0.0996691145224457 no 3032 0.108460913214489 4286 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2679 rapamycin 1 nM -1.23573969126819 0.0994888052488607 no 3033 0.108277669389865 4209 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1155 4088-0394 48.2 µM -1.23577571490143 0.0994822156739546 no 3034 0.108270972199311 4295 2326248 SGTC_1202 1988-0068 29.6 µM -1.23709286447725 0.0992414968732507 no 3035 0.108026304270859 4289 2850480 SGTC_1011 4112-3381 17.4 µM -1.23832043705136 0.0990175326290998 no 3036 0.107798634409084 4369 2877139 SGTC_919 tnp00227 403.569 nM -1.23976369416072 0.0987546909960856 no 3037 0.107531405236926 4277 1269246 A methoxyflavone. YNL221C POP1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.24182296290128 0.0983805477332767 no 3038 0.107150944212885 4305 75037 A free radical scavenger. SGTC_3349 9149703 23.001 µM -1.24248857216195 0.0982598371562654 no 3039 0.107028177144857 4342 4910494 SGTC_1474 0330-0125 5.35 µM -1.24687547944103 0.0974669688824025 no 3040 0.106221579469753 4357 X1474 SGTC_3025 9087895 49.47 µM -1.24739675139407 0.0973730695440639 no 3041 0.106126028567224 4294 17173641 SGTC_203 k066-0004 30.888 µM -1.25686531065822 0.0956789849114825 no 3042 0.104401205824591 4397 6795412 SGTC_3099 9120367 49.47 µM -1.25772961096057 0.0955254338832771 no 3043 0.104244779784191 4372 24824940 SGTC_1838 st055369 84.5 µM -1.25947401823673 0.0952160761714378 no 3044 0.103929584503921 4317 676036 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.25952839813666 0.0952064441701232 no 3045 0.103919769772932 4350 688798 SGTC_1857 st056007 79.3 µM -1.26037086959537 0.0950573136592841 no 3046 0.103767802569758 4299 619834 SGTC_348 k064-0012 10.7 µM -1.26077766381859 0.0949853664027235 no 3047 0.103694481706741 4263 5066323 SGTC_2511 berberine 10.47 µM -1.26342432546295 0.0945182465220449 no 3048 0.103218363314033 4316 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_173 1273-0061 2.693 µM -1.26489885480369 0.0942587366948734 no 3049 0.102953793970627 4305 2847414 YPL266W DIM1 SGTC_3226 9131256 49.47 µM -1.26491432052466 0.0942560175927196 no 3050 0.102951021626677 4299 17178073 SGTC_3044 9093193 49.47 µM -1.26515120841359 0.094214376432899 no 3051 0.102908564511692 4359 25236277 SGTC_2441 5730946 39.09 µM -1.2658506700515 0.0940915012856484 no 3052 0.102783275129916 4395 1774275 SGTC_3160 9100216 49.47 µM -1.26608756456919 0.0940499125963568 no 3053 0.102740867108265 4319 17191039 SGTC_3327 9140648 26.9345 µM -1.26711197108539 0.093870226140638 no 3054 0.102557627849732 4369 8029710 SGTC_1567 st069303 68.4 µM -1.26714578868501 0.0938642986737676 no 3055 0.102551582828276 4379 5581319 SGTC_2079 5212404 121 µM -1.26888416051181 0.0935599730569386 no 3056 0.10224119121221 4299 758462 SGTC_2954 9074818 52.69 µM -1.26931578629316 0.0934845241415548 no 3057 0.10216422911426 4366 16648742 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.26991320481422 0.0933801685337053 no 3058 0.102057774482628 4307 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1829 berberine 14.4 µM -1.27029455578333 0.0933136000904567 no 3059 0.101989863371077 4298 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2150 5556613 200 µM -1.27133835846839 0.0931315737142334 no 3060 0.101804150827714 4367 743190 SGTC_2256 7954252 200 µM -1.27243093792222 0.0929413225046211 no 3061 0.10161002377234 4349 2972920 SGTC_2364 9055074 200 µM -1.2743678475387 0.0926047542433954 no 3062 0.101266540793612 4355 6470630 SGTC_55 0767-0285 6.563 µM -1.27465731777185 0.0925545318114755 no 3063 0.101215280175591 4253 3116166 SGTC_2838 9002687 71.43 µM -1.27537868067385 0.0924294646531146 no 3064 0.101087620444508 4342 6457060 SGTC_2156 5649887 115 µM -1.27893003698482 0.0918155668523071 no 3065 0.100460847064912 4374 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2593 nobiletin 86.24 µM -1.28405182517021 0.0909355260074962 no 3066 0.0995619113023814 4349 72344 An anti-infammatory. SGTC_3216 9129716 49.47 µM -1.29310909911393 0.0893946213662722 no 3067 0.0979866642697738 4286 8056934 SGTC_1724 st037281 8.293 µM -1.29451823885025 0.0891566422714505 no 3068 0.0977432367352781 4323 574124 YDL195W SEC31 SGTC_2368 9071271 200 µM -1.29508289306639 0.0890614144542999 no 3069 0.0976458177843329 4344 27209959 SGTC_2165 5727197 32.143 µM -1.29585653321314 0.0889310645174435 no 3070 0.097512458425095 4443 1361712 SGTC_3107 9121808 49.47 µM -1.29595855958785 0.0889138847904051 no 3071 0.0974948811894068 4309 662681 SGTC_118 0083-0097 135.343 µM -1.29635610518918 0.088846967581945 no 3072 0.0974264136877735 4339 5207356 SGTC_191 3914-0123 66.505 µM -1.29819432407228 0.0885380352962247 no 3073 0.097110284024838 4386 3144412 SGTC_2092 5303694 80.6725 µM -1.3016963653567 0.0879516956046218 no 3074 0.096510101287374 4365 1963699 SGTC_1804 st050076 49.1 µM -1.3094077652583 0.0866708075837741 no 3075 0.0951981312467829 4398 3895976 SGTC_1446 4239-0190 62 µM -1.31035480322361 0.0865144677914606 no 3076 0.095037917925283 4389 1340085 SGTC_338 4055-0136 114 µM -1.3145575298784 0.0858232125323488 no 3077 0.0943293257136674 4360 2900563 SGTC_3211 9128781 49.47 µM -1.32007643538656 0.0849217645879391 no 3078 0.0934047497398485 4337 17194361 SGTC_2740 felodipine 17.08 µM -1.32369183818174 0.0843350911109673 no 3079 0.0928027051031081 4431 3333 L-type calcium channel blocker SGTC_3041 9091929 49.47 µM -1.32412243172421 0.0842654216359831 no 3080 0.0927311934076009 4384 25236887 SGTC_1007 4101-0031 70 µM -1.32415201275135 0.0842606370503881 no 3081 0.0927262821749658 4371 1146276 SGTC_1659 st012954 42.1 µM -1.32512234467081 0.0841038036526394 no 3082 0.0925652880510714 4346 24207262 SGTC_539 4859-0462 2.54 µM -1.32572503256458 0.0840065024361058 no 3083 0.0924653963135551 4412 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3052 9092717 49.47 µM -1.32641919175979 0.083894538360995 no 3084 0.0923504426431891 4392 25237534 SGTC_1136 pergolide 1.05886 µM -1.32843710656447 0.0835696961887728 no 3085 0.0920168739459651 4321 47811 A dopamine receptor agonist. SGTC_3116 9124943 49.47 µM -1.32900332272316 0.0834787172303066 no 3086 0.0919234368271752 4351 41905195 YPL160W CDC60 SGTC_1207 2099-0101 141 µM -1.33347120569077 0.0827634323542792 no 3087 0.0911886093485944 4390 5837381 SGTC_18 0111-0177 500 nM -1.3394594882398 0.0818119851439961 no 3088 0.0902105672058153 4471 721752 SGTC_2703 st077852 53.4 µM -1.34052661792297 0.0816433033545643 no 3089 0.0900370982598981 4422 6281836 SGTC_3207 9114163 49.47 µM -1.34355778712984 0.0811655950203771 no 3090 0.0895457137988837 4394 849233 SGTC_3112 9123419 49.47 µM -1.34805906488383 0.0804600952743574 no 3091 0.0888196930655981 4459 17015854 SGTC_1477 0139-0234 16 µM -1.34862796728563 0.0803712601547115 no 3092 0.0887282464603521 4408 620880 SGTC_2725 haloperidol 53.21 µM -1.35007658434038 0.0801453906691881 no 3093 0.0884957092210152 4358 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2291 7917025 104.35 µM -1.3506598775547 0.0800545787625187 no 3094 0.0884022052132357 4292 2964612 SGTC_1622 st003707 19.4 µM -1.35099945048077 0.0800017470828681 no 3095 0.0883478043616199 4407 10140899 SGTC_727 3032-0951 202 µM -1.35172340236926 0.0798892006958738 no 3096 0.0882319078594424 4437 3652836 SGTC_1772 st048439 82.2 µM -1.35544231730092 0.0793129405661791 no 3097 0.0876383374229758 4452 2927068 YDL195W SEC31 SGTC_37 0566-0070 1.56 µM -1.35794782078054 0.0789264809271945 no 3098 0.0872401208881538 4315 1626686 SGTC_3100 9120536 49.47 µM -1.35938862218243 0.0787048924423112 no 3099 0.0870117372955895 4290 16421196 SGTC_1148 3909-7663 27.7 µM -1.35969425095059 0.0786579488406513 no 3100 0.086963349085021 4442 4084526 SGTC_802 4112-3352 742 µM -1.36093051297102 0.0784682794425631 no 3101 0.0867678248689968 4446 704594 SGTC_1913 st060213 96.1 µM -1.36120305729902 0.0784265119167295 no 3102 0.0867247641432951 4411 688959 SGTC_258 haloperidol 50.781 µM -1.36166642869461 0.0783555387608168 no 3103 0.0866515902961601 4407 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2461 5755302 26.15 µM -1.36287959317827 0.0781699528046437 no 3104 0.0864602305505138 4430 2788904 SGTC_2610 ononetin 44.17 µM -1.36339959785919 0.0780905063402062 no 3105 0.086378303886048 4376 259632 SGTC_2147 5545932 89.7195 µM -1.36340016088401 0.0780904203543203 no 3106 0.0863782152130366 4458 797404 SGTC_2185 6113692 200 µM -1.36366102538575 0.0780505885128111 no 3107 0.0863371379502279 4400 874150 SGTC_120 rhodamine 6G 52.259 µM -1.36484091574286 0.0778706215636993 no 3108 0.0861515279022219 4429 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1745 st081495 74 µM -1.36671529558996 0.0775853729059311 no 3109 0.0858572808253306 4270 13842402 YBL026W LSM2 SGTC_2234 tolnaftate 200 µM -1.3679962219411 0.0773908945696135 no 3110 0.0856566293503438 4515 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_508 roscovitine 141 µM -1.37021638858999 0.0770546921981437 no 3111 0.0853096819626585 4492 160355 A CDKinase inhibitor. SGTC_363 0455-0021 3.06 µM -1.37272800672501 0.0766756943997112 no 3112 0.0849184595597813 4365 4597466 SGTC_2860 9025725 38.96 µM -1.37501259278999 0.0763321879828493 no 3113 0.0845637703313309 4469 40546248 SGTC_1526 st051518 75 µM -1.37659012673303 0.0760956770284691 no 3114 0.0843195025764314 4410 673993 SGTC_2541 muurolladie-3-one 83.07 µM -1.38757136025292 0.0744647526657153 no 3115 0.0826338037338417 4383 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2903 5923464 63.88 µM -1.3879213690692 0.0744132119207795 no 3116 0.0825804950187096 4441 2876576 SGTC_2314 7727897 200 µM -1.38860337536885 0.0743128609474088 no 3117 0.0824766952053624 4399 900724 SGTC_1703 st026983 48.3 µM -1.39658058528081 0.0731467488574593 no 3118 0.0812698659612735 4455 1104023 SGTC_2880 9042983 58.44 µM -1.39707001981645 0.0730756615819476 no 3119 0.0811962581074802 4383 6464714 SGTC_2504 purpurogallin 52.29 µM -1.40115183438915 0.0724848613584698 no 3120 0.08058433700598 4356 5281571 An antioxidant. SGTC_582 0987-0078 156 µM -1.40488731397115 0.0719474024490259 no 3121 0.0800273947535038 4494 1625765 SGTC_187 1488-2104 32.728 µM -1.41134049359143 0.0710261285500668 no 3122 0.0790721199592533 4443 2852859 SGTC_2569 tetrandrine 100 µM -1.41693391022856 0.0702349502902112 no 3123 0.0782511255154408 4455 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2560 caryophyllene 100 µM -1.42016251793142 0.0697813651320389 no 3124 0.07778018647484 4470 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2663 amphotericin b 100 µM -1.42131431955708 0.0696200959921956 no 3125 0.0776127012190388 4477 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1059 3448-6867 171 µM -1.42187718420402 0.0695413911257841 no 3126 0.0775309538664782 4420 3934407 SGTC_632 0781-2353 4.65 µM -1.43126633762778 0.0682385950870006 no 3127 0.076176948813576 4491 6811515 YHR007C ERG11 SGTC_906 1165-0455 526 µM -1.43156316258139 0.0681977182923451 no 3128 0.0761344392123961 4442 3252859 SGTC_91 0417-1751 58.384 µM -1.43355770222988 0.067923533321366 no 3129 0.0758492606567817 4557 6795624 SGTC_1992 st073643 23.3 µM -1.43901074081908 0.0671782607839789 no 3130 0.0750737398031505 4454 3161292 SGTC_336 4111-0029 111 µM -1.43923033103839 0.0671483821235513 no 3131 0.0750426372260578 4472 3131175 SGTC_2836 9010338 19.48 µM -1.44074920317676 0.0669419972490689 no 3132 0.0748277744379631 4424 2994051 SGTC_2822 7994718 71.43 µM -1.44088254440963 0.0669239022511093 no 3133 0.0748089341457423 4465 1018011 SGTC_2705 st078069 42.8 µM -1.44400582355362 0.0665011407817171 no 3134 0.0743686686120096 4479 1530061 SGTC_950 1165-0508 94.1 µM -1.44433460916391 0.0664567574940971 no 3135 0.0743224374735957 4442 6148369 SGTC_853 0419-0306 21 µM -1.44722165667087 0.0660680146307982 no 3136 0.0739174264539927 4470 762713 SGTC_2304 7443016 91.4 µM -1.44729820254287 0.0660577317037161 no 3137 0.0739067111713134 4410 939854 SGTC_1336 1486-0901 104 µM -1.44739412746748 0.066044847207427 no 3138 0.0738932847855627 4471 5006114 SGTC_294 k038-0071 157 µM -1.44902981971147 0.0658254429512539 no 3139 0.0736646275684903 4485 24152826 SGTC_775 4577-0580 57.3 µM -1.44929535861093 0.0657898781413216 no 3140 0.0736275583583743 4487 2006902 SGTC_1018 4259-0013 28.1 µM -1.45015912322389 0.0656742933082659 no 3141 0.0735070755278503 4503 6801262 SGTC_130 0136-0219 337.655 µM -1.45356167113466 0.0652205116917075 no 3142 0.0730339349683735 4335 234244 SGTC_3144 9087057 49.47 µM -1.46108382659229 0.0642259544397961 no 3143 0.0719962190703377 4388 17249618 SGTC_1704 st028805 70.8 µM -1.46529422735423 0.0636744360067809 no 3144 0.0714203304006584 4516 2876101 SGTC_1100 amiodarone 5.07 µM -1.46914700653348 0.063172997276229 no 3145 0.0708964601491846 4512 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1617 st002906 78 µM -1.47556385424109 0.0623446775300367 no 3146 0.0700305072843183 4456 5150859 SGTC_60 0986-0278 202 µM -1.47630141556277 0.0622500145603124 no 3147 0.0699314971556267 4437 3110598 SGTC_20 0481-0013 4.944 µM -1.48170103745306 0.0615604061496635 no 3148 0.0692099304665358 4527 182045 SGTC_965 1291-5240 308 µM -1.48278012626403 0.0614233091593821 no 3149 0.0690664189589702 4480 2834598 SGTC_245 methotrexate 289.6 µM -1.48690572376573 0.0609013546678848 no 3150 0.0685198561653706 4437 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_934 2950-0684 338 µM -1.49301110830043 0.0601352964279777 no 3151 0.0677171395917566 4502 1121253 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.49490221942195 0.0598995504144136 no 3152 0.0674699814890186 4498 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1587 estradiol valerate 56.1 µM -1.49584122555846 0.0597827631179106 no 3153 0.0673475177188717 4541 13791 A steroid. SGTC_261 5-fluorouridine 15.376 µM -1.49972348324685 0.0593018062984169 no 3154 0.0668430224817911 4514 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_899 1083-0020 478 µM -1.50818861183641 0.0582636192703558 no 3155 0.0657531305521591 4544 767123 SGTC_3277 9138724 49.47 µM -1.50950450512742 0.058103524492717 no 3156 0.065584952439345 4462 15943418 SGTC_291 SEC14.278 35.5 µM -1.51343819428237 0.0576270028941151 no 3157 0.0650841946872836 4514 1068044 SGTC_2704 st078022 71.1 µM -1.51361312567749 0.0576058835411288 no 3158 0.0650619950627478 4523 54697681 SGTC_2877 9040724 71.43 µM -1.5149879980052 0.0574401079670324 no 3159 0.0648877217855017 4469 6463895 SGTC_3237 9133362 49.47 µM -1.51748499816175 0.0571399915668658 no 3160 0.0645721391401212 4480 43845137 SGTC_676 falcarinol 140 µM -1.52182840359416 0.056620896496836 no 3161 0.0640260412568843 4519 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2155 5570423 76 µM -1.53056206697268 0.0555883587839254 no 3162 0.0629388313934042 4494 797402 SGTC_62 0180-0423 3.232 µM -1.53268220715863 0.055339960718906 no 3163 0.0626770876296111 4465 30102 YGL099W LSG1 SGTC_1489 4065-0444 182 µM -1.53360072029189 0.0552326191596798 no 3164 0.0625639555091292 4517 2877968 SGTC_149 3970-0822 46.1 µM -1.53367286974762 0.0552241944221321 no 3165 0.0625550756978975 4484 3114250 YBL034C STU1 SGTC_2712 st079126 47.7 µM -1.53491216868823 0.0550796425308395 no 3166 0.062402702019497 4510 3152970 SGTC_618 k072-0232 33.2 µM -1.53614484309315 0.0549361600337836 no 3167 0.0622514300926227 4541 5872756 YGL099W LSG1 SGTC_1638 st008370 60.6 µM -1.54017185516829 0.0544694763432199 no 3168 0.0617592341986903 4453 24207134 SGTC_1279 0874-0590 65.2 µM -1.54061066256232 0.0544188137141722 no 3169 0.061705785652298 4585 3523074 SGTC_1963 st076565 50.3 µM -1.54234748684277 0.0542186538305997 no 3170 0.0614945875916295 4528 4914280 SGTC_3205 9113483 49.47 µM -1.55093903967456 0.0532370774054002 no 3171 0.0604581467790017 4509 17018033 SGTC_3348 9149464 3.537 µM -1.55338147625145 0.0529606182050028 no 3172 0.0601660128082547 4459 1951442 SGTC_1239 0337-0584 35.4 µM -1.55369629318359 0.0529250670919407 no 3173 0.0601284388488471 4566 914301 YML130C ERO1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.55473963021105 0.0528073821940151 no 3174 0.0600040460451763 4541 6708784 An antioxidant flavonoid SGTC_1497 4476-2978 41.3 µM -1.56412903488055 0.0517576070251575 no 3175 0.0588936342886188 4572 1528379 SGTC_3062 9077494 49.47 µM -1.56837197136947 0.0512887025034582 no 3176 0.0583971741903732 4465 16459633 SGTC_2463 5473429 200 µM -1.57201792369082 0.0508884784845415 no 3177 0.05797319724906 4534 5399405 SGTC_830 4076-0286 57.8 µM -1.57539395826512 0.0505201047297275 no 3178 0.0575827690549151 4586 6866659 SGTC_1395 3486-0190 4.35 µM -1.58038435727558 0.0499794751685097 no 3179 0.0570094358465876 4512 6748079 SGTC_1778 st046819 58.9 µM -1.58746393062314 0.0492204433839906 no 3180 0.0562038049491036 4585 671715 SGTC_930 2810-3379 265 µM -1.59162935521615 0.0487781694108014 no 3181 0.055734005077941 4525 1015764 SGTC_1035 k081-0041 55.2 µM -1.59188010494007 0.0487516471400389 no 3182 0.0557058233101607 4551 731709 SGTC_2383 9036125 200 µM -1.59398266411762 0.0485297087614087 no 3183 0.0554699589039837 4501 79580 SGTC_3285 9112818 20.8695 µM -1.59509804176883 0.0484123019940248 no 3184 0.0553451566638756 4532 17017947 YPR165W RHO1 SGTC_1572 epiandrosterone 68.9 µM -1.59717105784406 0.0481946959210923 no 3185 0.0551137911293591 4490 441302 A steroid. SGTC_2979 9012552 45.46 µM -1.59793273613189 0.0481149388376745 no 3186 0.0550289738112769 4560 17100905 SGTC_1759 st043059 70 µM -1.59875891453921 0.0480285472490904 no 3187 0.0549370906703785 4555 669426 SGTC_835 0312-0010 67.2 µM -1.60355556982276 0.0475294219748718 no 3188 0.0544060254459792 4569 1626196 SGTC_1881 5652484 16 µM -1.60741828223746 0.0471305076808943 no 3189 0.0539813211185999 4531 2255129 SGTC_2756 carbadox 75.1 µM -1.61172526085239 0.046688882291669 no 3190 0.0535108691009227 4470 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2264 7948757 110.76 µM -1.61732028952736 0.046120148780513 no 3191 0.052904580924007 4523 2971411 SGTC_3078 9116413 49.47 µM -1.61921601270106 0.0459287158177133 no 3192 0.0527003969396575 4501 17177322 SGTC_2512 diallyl trisulfide 49.23 µM -1.62402313106462 0.0454461470646625 no 3193 0.052185435971039 4602 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_189 3970-0742 2.116 µM -1.62403932404773 0.0454445284290784 no 3194 0.0521837080814731 4532 2891807 SGTC_3034 9090421 49.47 µM -1.6252200104425 0.0453266329886929 no 3195 0.0520578440734098 4491 17173761 SGTC_606 k015-0008 38.6 µM -1.64042385419096 0.0438303537323068 no 3196 0.0504585344409463 4622 1970475 SGTC_1767 st044992 70.3 µM -1.64737038765952 0.0431601036202434 no 3197 0.0497409690719142 4592 9600693 SGTC_1621 st003705 32.4 µM -1.64921894015511 0.0429831439074622 no 3198 0.0495513945431741 4581 24207032 SGTC_1729 st035615 45.989 µM -1.65102510187611 0.0428108088830672 no 3199 0.049366724693332 4561 17385451 SGTC_957 1187-1561 14.1 µM -1.66161465249374 0.0418116113653799 no 3200 0.0482950317705614 4516 1538454 SGTC_302 1094-0063 18.9 µM -1.66945948027329 0.0410836426213917 no 3201 0.0475131771093672 4573 5440289 SGTC_2596 sinensetin 100 µM -1.67163283900131 0.0408837919733262 no 3202 0.0472983725401541 4575 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_401 neomycin 50 µM -1.67884536369868 0.0402262111717664 no 3203 0.0465910924928661 4587 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3274 9138298 49.47 µM -1.68164749836163 0.0399730632230863 no 3204 0.0463186071529675 4548 17015756 SGTC_1384 3089-0840 101 µM -1.68553778696739 0.0396237582255019 no 3205 0.0459424303866992 4575 1069836 SGTC_691 1548-0686 185 µM -1.688945610012 0.0393198166680131 no 3206 0.0456149267861889 4549 46495133 SGTC_2711 st079103 59.1 µM -1.69778205991183 0.0385405293848416 no 3207 0.0447744515546708 4523 54693780 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.69851307710232 0.0384766286253378 no 3208 0.0447054833289037 4587 6708561 SGTC_3193 9111931 49.47 µM -1.70558670098805 0.0378627485821705 no 3209 0.0440425285977335 4585 17087244 SGTC_1761 st044296 37 µM -1.7100894497265 0.0374761602593021 no 3210 0.0436246667123351 4606 1826700 SGTC_2764 methyldopa 94.69 µM -1.71142579534979 0.037362049181669 no 3211 0.0435012693409919 4546 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2212 7123476 200 µM -1.71226219338175 0.0372907733461226 no 3212 0.0434241802940775 4642 1085715 SGTC_2026 5148700 152 µM -1.71522680694257 0.03703903026572 no 3213 0.043151825926726 4582 79838 SGTC_2763 lisinopril 49.32 µM -1.71919985125398 0.0367038352744181 no 3214 0.0427889939516124 4505 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_298 1391-0729 10 µM -1.71940558256893 0.0366865460658621 no 3215 0.0427702732195693 4562 3237558 SGTC_2301 7769476 200 µM -1.74054099662881 0.0349455508389693 no 3216 0.0408820339513384 4592 977820 SGTC_2179 6298986 200 µM -1.74215926215332 0.0348150921168612 no 3217 0.0407402900747839 4567 738374 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.74286073773962 0.034758666053619 no 3218 0.0406789718529533 4602 803109 SGTC_199 4063-0024 41.6 µM -1.76337547930333 0.0331414091685466 no 3219 0.0389185913131258 4656 306215 SGTC_2258 7960471 200 µM -1.77061259456971 0.032585883235951 no 3220 0.0383125730655774 4624 2974708 SGTC_3087 9117406 49.47 µM -1.77541511187264 0.032221495214981 no 3221 0.0379146853027909 4599 42546093 SGTC_2104 5389443 200 µM -1.78321056118324 0.0316371849244222 no 3222 0.0372760169648706 4625 2244536 SGTC_1381 2324-0066 62.1 µM -1.78433464532073 0.0315536557325909 no 3223 0.0371846519062398 4631 10885928 SGTC_3218 9131285 49.47 µM -1.78681978505723 0.0313696351726653 no 3224 0.0369833102588999 4592 17156417 SGTC_69 0096-0274 206.684 µM -1.79152546588101 0.0310236181175293 no 3225 0.0366045058881983 4643 6741392 SGTC_735 3076-0345 636 µM -1.79749361126749 0.0305893185481725 no 3226 0.0361286457315616 4624 2888990 SGTC_1627 st003713 25.6 µM -1.79996912429466 0.0304106598943952 no 3227 0.0359327568224886 4629 16195070 YER133W GLC7 SGTC_2286 7945697 125 µM -1.80000691438397 0.0304079392842009 no 3228 0.0359297732246135 4587 1245733 SGTC_643 k048-0106 28.4 µM -1.80216900311421 0.0302526201892378 no 3229 0.0357594099571808 4652 6763920 SGTC_989 1501-0895 10.3 µM -1.80785626509097 0.0298471985555112 no 3230 0.0353144370411273 4626 2830112 SGTC_2556 citropten 84.59 µM -1.81053105183572 0.0296580880149296 no 3231 0.0351067367293266 4603 2775 A potential DNA crosslinker. SGTC_640 3381-0960 37.1 µM -1.81234129056379 0.0295306670521685 no 3232 0.034966739128341 4679 1745025 SGTC_3070 9117005 49.47 µM -1.81645208681196 0.0292429990930677 no 3233 0.0346505256873496 4703 8779016 SGTC_1626 st003712 1.76 µM -1.82412598073995 0.0287122181182836 no 3234 0.0340665142842561 4627 24207035 SGTC_890 0929-0006 47.2 µM -1.82662241474526 0.0285412835899591 no 3235 0.0338782804129215 4635 1378169 SGTC_818 4072-2707 53.5 µM -1.82738695891998 0.0284891037529256 no 3236 0.0338208043670727 4573 882871 SGTC_3069 9117009 49.47 µM -1.82936554075835 0.0283544346818656 no 3237 0.0336724331113616 4651 41904981 SGTC_2363 9053361 176 µM -1.83151043514469 0.0282090446543291 no 3238 0.0335121958025463 4638 6469797 YMR079W SEC14 SGTC_2028 5153890 36.43 µM -1.832454077494 0.0281452774331073 no 3239 0.0334418987910221 4624 2830968 YPR165W RHO1 SGTC_1752 st044819 83.042 µM -1.83297238736736 0.0281103034115316 no 3240 0.033403338775528 4577 441209 YML126C ERG13 SGTC_3278 9139605 49.47 µM -1.83567417228696 0.0279285803636798 no 3241 0.0332029300009674 4614 7958859 SGTC_2183 6420625 130.508 µM -1.84182695485835 0.0275183913620101 no 3242 0.0327502329617787 4661 2897619 SGTC_246 cycloheximide 667 µM -1.84190480074482 0.0275132339415232 no 3243 0.0327445381384792 4608 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.84420907807876 0.0273609362857304 no 3244 0.0325763379376852 4652 616764 SGTC_1824 st053723 68.6 µM -1.84582585098198 0.0272544984159573 no 3245 0.0324587478888823 4646 675225 SGTC_1345 1488-0192 31.4 µM -1.84795188834043 0.0271150598038436 no 3246 0.032304651577833 4675 658348 SGTC_52 0329-0193 875 nM -1.86702756450385 0.0258903929352141 no 3247 0.0309488693220643 4655 3739292 SGTC_1438 4092-1045 4 µM -1.87227224718539 0.0255619102453917 no 3248 0.0305844741335018 4681 1351342 SGTC_1132 3456-3614 2.5 µM -1.88038837185655 0.0250604674053137 no 3249 0.0300275835778162 4612 3125502 SGTC_2681 menadione 3.18 µM -1.88470274582292 0.0247972839885435 no 3250 0.0297349907257775 4670 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1686 st019653 115.5 µM -1.89302136146903 0.0242963777590028 no 3251 0.0291775143802208 4654 97252 SGTC_2627 acetyl isogambogic acid 100 µM -1.89528767825892 0.0241613933629185 no 3252 0.0290271498449137 4653 6857789 A caspase activator and apoptosis inducer. SGTC_997 3996-0078 137 µM -1.903075274576 0.0237023473583797 no 3253 0.0285153618610675 4692 735687 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.9093754916892 0.023336362908874 no 3254 0.0281068350312121 4654 23847180 SGTC_2513 baicalein 25.65 µM -1.91837565180717 0.0228217951929125 no 3255 0.0275316980449572 4632 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2769 toremifene 3.73 µM -1.94295418847 0.0214650397082464 no 3256 0.0260108468598702 4654 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3249 9135183 49.47 µM -1.94485934637026 0.0213627821012168 no 3257 0.0258959545448859 4628 4902779 SGTC_644 1498-1197 63.3 µM -1.95216005616121 0.0209747284910562 no 3258 0.0254596024371937 4697 6741615 SGTC_1252 0493-0875 34.8 µM -1.95253148977461 0.0209551462514183 no 3259 0.0254375680425874 4643 3960963 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.95440981388137 0.0208563565050348 no 3260 0.0253263855073038 4683 94937 An inhibitor of serotonin biosynthesis. SGTC_556 4058-0063 51.5 µM -1.95541850568753 0.020803467649697 no 3261 0.0252668468127858 4679 6615692 SGTC_2020 4017018 200 µM -1.9586355686725 0.0206355450145261 no 3262 0.0250777404957571 4665 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1807 st050092 58.9 µM -1.96774489121771 0.0201662770186801 no 3263 0.0245486989215494 4676 5008496 SGTC_1453 4237-0541 195 µM -1.96924847138681 0.020089696636042 no 3264 0.0244622826083541 4677 739892 SGTC_3279 9140807 49.47 µM -1.96981325567603 0.0200609948228427 no 3265 0.0244298884061291 4709 45595718 SGTC_2238 6671620 73.2395 µM -1.97768911207818 0.0196643617789165 no 3266 0.0239818946522231 4596 729941 SGTC_2023 5144124 124 µM -1.98798828910798 0.0191557518939059 no 3267 0.0234064925880718 4657 2830192 SGTC_981 1488-1094 54.9 µM -1.98963364552015 0.0190755434061113 no 3268 0.023315653509663 4656 3449522 SGTC_236 1509-0011 5.31 µM -2.00440071775219 0.0183683704415856 no 3269 0.0225135762505272 4682 3107280 SGTC_2889 9059656 51.95 µM -2.01895399880674 0.0176934087117607 no 3270 0.0217460004735699 4711 3949838 SGTC_1149 3909-7961 23.3 µM -2.02393700367753 0.0174672204490567 no 3271 0.0214883169759784 4708 735261 SGTC_690 glyoxal 20.3 µM -2.02679135139504 0.0173387716423013 no 3272 0.021341877659624 4514 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1277 0873-0036 22 µM -2.03541037228828 0.0169557914633973 no 3273 0.0209047992714483 4729 5965735 SGTC_1131 3454-3128 32.3 µM -2.05325558379102 0.0161857931964602 no 3274 0.020023898069395 4652 710982 SGTC_137 0438-0332 85.389 µM -2.05487387290859 0.0161174714669894 no 3275 0.0199455943084903 4640 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_782 0083-0095 30.5 µM -2.05749438264611 0.0160073615854888 no 3276 0.0198193473545242 4683 3591729 An indicator and reagent. SGTC_1353 1498-1206 8.11 µM -2.06560981494032 0.015670444577159 no 3277 0.0194326684645915 4702 6756808 SGTC_2330 7979373 200 µM -2.07394245302964 0.0153308587451333 no 3278 0.0190423278505074 4632 1863007 SGTC_2051 5263410 176 µM -2.07450234007626 0.0153082695971326 no 3279 0.0190163408275691 4652 227584 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.08951280269818 0.0147132261235803 no 3280 0.0183307933512373 4682 688803 SGTC_2893 9048488 25.97 µM -2.09257025753576 0.0145944928510503 no 3281 0.0181937669610397 4712 6467338 SGTC_1670 st016595 4.04 µM -2.09647125737531 0.0144441992058177 no 3282 0.0180202035210193 4728 597879 SGTC_2882 9058044 58.44 µM -2.11810198341918 0.0136347884273901 no 3283 0.0170832158019072 4703 18076804 SGTC_2851 9015922 71.43 µM -2.12011303111485 0.0135615641443552 no 3284 0.0169982571365571 4697 2996893 SGTC_2231 micatex 6.853 µM -2.12706262145187 0.0133111295925087 no 3285 0.0167074402265403 4716 20737 An antifungal of unknown mechanism. SGTC_2924 9010168 62.78 µM -2.12755584438777 0.013293508669864 no 3286 0.0166869632636916 4689 2993929 SGTC_2233 sulbentine 40.3845 µM -2.1299658374598 0.0132076985239601 no 3287 0.0165872169485317 4714 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_931 2812-0076 566 µM -2.13771494796454 0.0129350194826204 no 3288 0.016269942778888 4673 3450959 SGTC_2964 9083345 53.42 µM -2.14115917613606 0.0128153937242613 no 3289 0.0161306019582662 4685 17741579 SGTC_2105 5350118 200 µM -2.1451789493389 0.0126769893103878 no 3290 0.0159692710102264 4698 2133313 SGTC_815 1582-0027 36.9 µM -2.15210672145523 0.0124414944596215 no 3291 0.015694474945785 4719 3128206 SGTC_982 1491-0518 27.5 µM -2.15884117809943 0.0122162118752718 no 3292 0.015431245309803 4704 3091256 SGTC_1738 st035555 74 µM -2.16675625505745 0.0119559615698858 no 3293 0.0151267223098086 4688 5331140 SGTC_928 2764-0428 58.7 µM -2.17924163404279 0.0115552128207524 no 3294 0.0146568612694912 4733 662578 SGTC_2919 7978188 46.38 µM -2.18694407080587 0.011313845832627 no 3295 0.0143733035792651 4695 2980291 SGTC_521 r062-0005 13.8 µM -2.19308999082935 0.0111244092349011 no 3296 0.0141504480137008 4671 2832033 SGTC_1094 duloxetine 25.4 µM -2.19908962633264 0.0109421482478642 no 3297 0.0139357750065249 4724 60834 A selective serotonin reuptake inhibitor. SGTC_2845 9003024 42.97 µM -2.21462209485226 0.0104823146878634 no 3298 0.0133930070832098 4699 2990173 SGTC_3083 9117465 49.47 µM -2.21631533050785 0.0104332197503348 no 3299 0.0133349569100092 4696 16420915 SGTC_1647 st011722 22.4 µM -2.23647208122731 0.00986399740965882 no 3300 0.0126604320599967 4735 2854783 SGTC_1369 1866-0067 208 µM -2.24947541570477 0.00951134616675573 no 3301 0.0122411326072287 4715 3531355 SGTC_921 1561-0023 372 µM -2.26229024476473 0.0091746422189163 no 3302 0.0118397383725753 4722 24050882 SGTC_1283 0922-0125 16.4 µM -2.27614215600156 0.00882246805667146 no 3303 0.011418751330237 4725 3360884 SGTC_165 k038-0023 64.381 µM -2.27808282863919 0.00877408647327819 no 3304 0.011360821561985 4708 46368543 SGTC_2110 5483698 200 µM -2.29401664257726 0.0083855684406627 no 3305 0.0108947714022853 4724 2848765 YHR062C RPP1 SGTC_1922 5578187 25 µM -2.29403410372203 0.00838515110228056 no 3306 0.0108942699448883 4703 1350412 SGTC_1942 st076330 65.2 µM -2.29680600211928 0.00831913079644683 no 3307 0.0108149195097927 4725 24208414 SGTC_3196 9111891 49.47 µM -2.32361127023844 0.00770387611552702 no 3308 0.0100731689227685 4717 18891510 SGTC_2405 ticlatone 3.52 µM -2.3265316181042 0.00763932807579742 no 3309 0.00999510387362729 4607 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2422 chlorphenesin carbamate 384.24 µM -2.34834930694148 0.00717197813461352 no 3310 0.00942841390023538 4698 2724 A muscle relaxant with antifungal properties. SGTC_3187 9109394 49.47 µM -2.3675158766151 0.00678241693186612 no 3311 0.00895397583466611 4737 17098090 SGTC_1291 0993-0025 5.79 µM -2.37466409925679 0.00664198743023338 no 3312 0.00878246328066515 4728 4353356 SGTC_1272 0839-0021 27 µM -2.38752480523158 0.00639579521300224 no 3313 0.00848112902117739 4780 5027250 SGTC_1651 st011928 86.1 µM -2.39928942556546 0.00617769376167964 no 3314 0.00821346248050165 4754 720198 SGTC_1937 st074714 47.2 µM -2.40192864444796 0.0061296802715506 no 3315 0.00815444467100868 4717 17250970 SGTC_2294 7971431 200 µM -2.4028126291655 0.00611367262128062 no 3316 0.00813476061322651 4741 5741572 SGTC_1960 st011366 51.8 µM -2.40571933147157 0.00606129738737766 no 3317 0.00807032991583725 4769 3972846 SGTC_516 3992-2719 87.3 µM -2.40941955428899 0.0059951994143903 no 3318 0.00798895905697623 4680 5350887 YDR037W KRS1 SGTC_504 lovastatin 124 µM -2.44242942900001 0.00543324472641276 no 3319 0.0072943907941712 4740 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_665 3914-0008 307 µM -2.44421697649408 0.00540419593134117 no 3320 0.00725834652665588 4746 1069549 SGTC_1788 fluconazole 20 µM -2.44651283330912 0.00536708935644626 no 3321 0.00721228310428325 4745 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_923 1900-2434 73.3 µM -2.45024239739518 0.00530729335240444 no 3322 0.0071380036398316 4729 5910570 SGTC_45 0kpi-0036 14.9 µM -2.47392447584721 0.00494123564934313 no 3323 0.00668189721010119 4709 2795021 SGTC_924 2046-0044 21.3 µM -2.47957449759639 0.00485729731281719 no 3324 0.00657696243585047 4742 3623589 SGTC_2322 7413319 38.22 µM -2.52345344290576 0.00424751502002899 no 3325 0.00581042236567105 4708 1840400 SGTC_2798 7813637 45.45 µM -2.54234206839603 0.00400679942135888 no 3326 0.00550561754345018 4742 956368 SGTC_1964 st076914 61 µM -2.57369732994862 0.00363407532332875 no 3327 0.0050309125690603 4782 24208661 SGTC_1701 st028638 40.4 µM -2.60918133291421 0.00325004120465989 no 3328 0.00453795671074027 4772 3490878 SGTC_1492 4158-0558 28.5 µM -2.6299504580463 0.00304258688883557 no 3329 0.00426986560297275 4786 3967268 SGTC_432 NS 1619 61.3 µM -2.64016310488667 0.00294501785667773 no 3330 0.00414330676878898 4748 4552 A K+/calcium channel activator. SGTC_3141 9094609 49.47 µM -2.64259256233186 0.00292222668718834 no 3331 0.00411369867553936 4762 25236309 YDL196W YDL196W SGTC_1679 SEC14.276 6.7 µM -2.64666119002623 0.00288441406508169 no 3332 0.00406453765766782 4736 1005053 YMR079W SEC14 SGTC_1373 2887-0003 58.5 µM -2.67954146438863 0.00259466051681696 no 3333 0.00368615359562242 4755 776948 SGTC_2300 7976697 71.57 µM -2.68414793171973 0.00255623858768421 no 3334 0.00363574619580613 4715 2236109 SGTC_1849 st056239 19.2 µM -2.766514934251 0.0019506370477584 no 3335 0.00283294948326804 4770 5393181 SGTC_2835 9006588 71.43 µM -2.80492697508989 0.00171551616529461 no 3336 0.00251639902858264 4734 2345538 SGTC_2552 juarezic acid 87.02 µM -2.83728260492499 0.00153781363158602 no 3337 0.00227496598933728 4771 1549512 SGTC_427 1354-0053 47.3 µM -2.99707639774537 0.000882219296128122 yes 3338 0.00136291196305281 4787 6813657 SGTC_3343 9148379 18.9835 µM -3.00480955371374 0.0008582438770675 yes 3339 0.00132873593799759 4802 1955036 SGTC_2302 7771753 200 µM -3.05642795520985 0.000712950290989457 yes 3340 0.00111995651239739 4756 2203047 SGTC_2434 5670830 169.91 µM -3.08255090042403 0.000648399479278272 yes 3341 0.00102617314046566 4791 1549830 SGTC_874 0599-0792 117 µM -3.0937634653155 0.000622384039590614 yes 3342 0.000988174929242415 4791 765305 SGTC_2241 6772625 37.8075 µM -3.18878895755705 0.000437613304792461 yes 3343 0.000714350701942759 4714 2285411 SGTC_1683 st010134 710 nM -3.19473422234102 0.000427943314349677 yes 3344 0.000699798325335431 4784 3818134 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -3.2920756843532 0.000295292812266783 yes 3345 0.000497254220412486 4798 688664 SGTC_828 2074-0507 139 µM -3.39176050091467 0.000199914779179541 yes 3346 0.00034722556715899 4803 X828 SGTC_2471 5466956 24.79 µM -3.40328405235054 0.000190973904791419 yes 3347 0.000332905108903521 4804 724419 SGTC_229 benomyl 22.8748 µM -3.4302631984541 0.000171482102097979 yes 3348 0.000301498019569958 4808 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_424 splitomicin 100 mM -3.43562088291681 0.000167839799728548 yes 3349 0.000295598824007853 4794 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2795 7780010 54.55 µM -3.68928630930284 5.87027665166756e-05 yes 3350 0.000112442013616075 4791 953673 SGTC_3080 9117754 49.47 µM -3.77226221763526 4.10314394608391e-05 yes 3351 8.08870554639077e-05 4803 9550191 SGTC_3074 9116018 49.47 µM -4.3428065276437 2.87712426932317e-06 yes 3352 7.03370049606796e-06 4807 17027303 SGTC_1932 st074806 40.9 µM -4.4994069418905 1.30676961528343e-06 yes 3353 3.40716507169522e-06 4808 17251235 SGTC_3077 9117319 49.47 µM -4.84227007787145 2.12077163876457e-07 yes 3354 6.41820636644274e-07 4802 17154678