SGTCid condition conc unit PSK2|YOL045W.score PSK2|YOL045W.strain.pval PSK2|YOL045W.strain.significant PSK2|YOL045W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1081 sertraline 6 µM 7.91283697033012 7.77552883040107e-14 yes 1 1.25794365728169e-15 6 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_65 0798-0905 34.986 µM 5.80466717572443 3.11188207565321e-08 yes 2 3.2246991893699e-09 36 3602145 SGTC_2582 agaric acid 100 µM 5.48283650910973 1.59808841213675e-07 yes 3 2.09279900949431e-08 191 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_582 0987-0078 156 µM 4.88876986326246 2.60270454989362e-06 yes 4 5.07340154657317e-07 37 1625765 SGTC_1069 diphenylcyclopropenone 8.49 µM 4.59627516765782 9.21972704569912e-06 yes 5 2.15055304935155e-06 21 65057 A dermal irritant. YDR527W RBA50 SGTC_385 1494-0393 12.4 µM 4.21849087981505 4.24815511772852e-05 yes 6 1.22971458732544e-05 14 3090647 SGTC_1570 verbenone 133 µM 4.21221974459781 4.35289563826413e-05 yes 7 1.26436680063182e-05 12 29025 A natural terpanoid with antifungal properties. SGTC_1086 cerivastatin 2.18 µM 4.17420089945375 5.04200110965202e-05 yes 8 1.49516897411637e-05 9 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_779 1360-0071 233 µM 3.79222639429254 0.000206524947577622 yes 9 7.46513532375351e-05 33 7566 SGTC_1534 6-azauridine 81.6 µM 3.7643262289948 0.000227850087732299 yes 10 8.34993752835113e-05 28 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1702 st027038 51 µM 3.70918145292137 0.00027617278060365 yes 11 0.000103965188894872 18 5521182 SGTC_1507 4075-3230 155 µM 3.65928572153315 0.000327963252283453 yes 12 0.000126459612098657 13 659771 SGTC_2413 inermin 26.06 µM 3.54467029553518 0.000482978984228878 yes 13 0.000196552236704539 71 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_354 2783-3500 4.88 µM 3.41423404650758 0.00074054228111301 yes 14 0.000319808025113188 71 6740761 SGTC_1711 st032263 62.8 µM 3.33888964333089 0.000941936049155232 yes 15 0.00042056986570013 30 3958979 SGTC_2292 7671323 168.05 µM 3.33800520356357 0.000944573673175944 yes 16 0.000421910845594507 64 937504 SGTC_51 1013-0126 23.419 µM 3.30813190000078 0.00103774872496288 no 17 0.000469602816304217 42 1627850 SGTC_2008 4012253 172 µM 3.28991726058411 0.00109862314494365 no 18 0.000501084232587124 48 603940 SGTC_3299 9121982 43.1275 µM 3.25540082111355 0.00122303970640032 no 19 0.000566162184811901 58 17594604 YPL160W CDC60 SGTC_2283 7944793 200 µM 3.23176707905772 0.00131552747807467 no 20 0.000615136467978303 78 2970533 SGTC_1154 4088-0362 150 µM 3.22579924745531 0.00133987159620057 no 21 0.000628107181631229 57 6618304 SGTC_800 3448-7362 155 µM 3.22452348955126 0.00134512881602453 no 22 0.000630912522051215 229 15991913 SGTC_2750 bromebric acid 70.15 µM 3.20948841339938 0.00140852226390999 no 23 0.000664857028812706 68 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1098 clofazimine 15.1 µM 3.18570112507469 0.00151440896503543 no 24 0.000722018460137284 60 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_580 1123-0028 41 µM 3.16686888582217 0.0016033337899138 no 25 0.000770448877959908 77 1677248 YPR107C YTH1 SGTC_506 n9-isopropylolomoucine 153 µM 3.1498817850834 0.00168760072559071 no 26 0.00081668269736324 35 6610355 SGTC_72 0744-0168 198.391 µM 3.08729860332403 0.00203400225080223 no 27 0.00100992293937731 61 677577 SGTC_2407 paclitaxel 400 µM 3.08041990512907 0.00207577110924595 no 28 0.00103354471522334 77 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1414 3917-0015 5.4 µM 3.07624506494478 0.00210149956484108 no 29 0.00104812738082022 34 6618702 SGTC_3336 9143619 71.43 µM 3.01677529307977 0.00250076729772825 no 30 0.00127739559463725 52 45595730 SGTC_3307 9126885 69.2785 µM 2.99707721900733 0.00264741790667511 no 31 0.00136290829130092 75 24824909 SGTC_1851 st056236 18.9 µM 2.98009023677911 0.00278007445952515 no 32 0.00144081741420573 55 5393171 SGTC_196 k015-0023 18.111 µM 2.97821061615883 0.00279511561001259 no 33 0.0014496833742711 62 5211998 SGTC_2255 7941087 197.44 µM 2.96396707560509 0.00291150305671466 no 34 0.00151850389421368 82 935561 SGTC_3017 9080681 49.47 µM 2.95748137243075 0.00296593273653196 no 35 0.00155081744380552 55 16451914 SGTC_2941 9056145 11.23 µM 2.92657852832175 0.0032380797806323 no 36 0.00171356486592814 47 2119517 SGTC_819 1013-0258 27.7 µM 2.91910410980469 0.00330718903453271 no 37 0.00175519481932964 83 5753198 SGTC_2011 4012611 177 µM 2.91299903618111 0.00336461814079227 no 38 0.00178987853116816 74 2049887 SGTC_1140 3229-1848 2.98 µM 2.89748268912157 0.0035146319766053 no 39 0.00188085248690023 37 2849525 SGTC_3093 9117344 49.47 µM 2.88941312962384 0.00359500002515684 no 40 0.00192980815917687 74 24824913 SGTC_1096 rimcazole 32.2 µM 2.85111353796168 0.00399937931977219 no 41 0.00217832050089652 48 18528119 A dopamine reuptake inhibitor. SGTC_39 0986-0283 58.349 µM 2.84879034491023 0.00402517045246063 no 42 0.00219428947734307 100 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3202 9113761 49.47 µM 2.83852467963125 0.00414092726138794 no 43 0.00226613071824295 122 4798415 SGTC_2010 4012422 159 µM 2.82929811312547 0.00424749909712586 no 44 0.00233251111413553 86 952393 SGTC_1242 0402-0103 60.1 µM 2.82576591778043 0.00428894269520344 no 45 0.00235838596068989 78 432868 SGTC_1916 st067606 49.2 µM 2.81705506454481 0.00439269709131653 no 46 0.00242331077635368 115 19590279 SGTC_349 k015-0014 24 µM 2.79554843290026 0.00465852633814391 no 47 0.00259058689064971 87 2196908 SGTC_2277 7947813 106.88 µM 2.77522085918763 0.004922880900884 no 48 0.00275821159235665 93 1246798 SGTC_1891 st059073 26.2 µM 2.75564773362421 0.00518997193583536 no 49 0.00292880225700434 85 688754 SGTC_1939 st074455 53.6 µM 2.7283651517249 0.00558376404642709 no 50 0.00318245538739064 104 1644229 SGTC_1450 4112-4260 37.6 µM 2.7140081620878 0.00580146677605907 no 51 0.0033237264179599 90 1633175 SGTC_796 1234-0020 70.7 µM 2.66636953485071 0.00657876221592532 no 52 0.0038337680194108 83 46495034 SGTC_891 0929-0073 133 µM 2.62088310807393 0.00740546710987578 no 53 0.00438511636993589 89 5603632 SGTC_1815 st051655 58.2 µM 2.60568165494956 0.0077014766354661 no 54 0.00458458191045445 57 5984156 SGTC_874 0599-0792 117 µM 2.57514267877428 0.00832777689372166 no 55 0.00500993720203403 121 765305 SGTC_1866 st057638 64 µM 2.57105402538552 0.00841493468526497 no 56 0.00506947544036983 91 688802 SGTC_1454 4239-0054 42.6 µM 2.55722898470282 0.00871560217652424 no 57 0.00527548690132834 130 1340767 SGTC_2860 9025725 38.96 µM 2.52814143008147 0.00937911112161281 no 58 0.0057334074861571 86 40546248 SGTC_1445 4239-0156 97.7 µM 2.51958390904993 0.00958254460602617 no 59 0.00587468163101324 119 4008346 SGTC_1144 3486-0183 12.5 µM 2.51729147048508 0.00963769234400364 no 60 0.0059130475616768 118 6744069 SGTC_1291 0993-0025 5.79 µM 2.50173952241652 0.0100191919911539 no 61 0.0061792406729113 88 4353356 SGTC_1161 k007-0610 110 µM 2.48470643388097 0.0104520858538221 no 62 0.00648291542291861 256 5843850 SGTC_2308 7584454 197.62 µM 2.46576062820096 0.0109526566554681 no 63 0.00683613343823488 153 893577 SGTC_1726 st035556 14.5795 µM 2.44291070837091 0.0115840198554317 no 64 0.00728467074286686 174 5919439 SGTC_513 4245-1575 41.7 µM 2.40509851701105 0.0126982948995663 no 65 0.00808405325208111 284 719745 SGTC_2119 5528445 120.635 µM 2.40032466675196 0.0128453644071863 no 66 0.00819026799726425 133 791935 SGTC_1246 0422-0085 105 µM 2.38721691504493 0.0132567785976815 no 67 0.00848823569882648 170 264295 SGTC_2065 5221596 34.26 µM 2.3841940065541 0.0133532582794097 no 68 0.00855828804069505 122 788581 SGTC_1183 1254-0324 198 µM 2.37687178935355 0.0135894723059231 no 69 0.00873007788780915 116 5799357 SGTC_1117 retinoic acid 1.10837 µM 2.36716906089039 0.0139080306164099 no 70 0.0089623713686331 125 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_634 1611-4317 11.2 µM 2.36711201740974 0.0139099223356453 no 71 0.00896375290763555 134 2843522 SGTC_1626 st003712 1.76 µM 2.34536708224091 0.0146473970684329 no 72 0.00950417737318198 141 24207035 SGTC_1893 st059353 36.1 µM 2.34381391315268 0.0147013364653713 no 73 0.00954384606722797 144 3112488 SGTC_219 mitoxanthrone 164.414 µM 2.34082508890461 0.0148056150878672 no 74 0.00962058952754459 163 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_557 1315-0110 16.2 µM 2.33093798417822 0.0151551162955868 no 75 0.00987831500450519 161 6833801 SGTC_2739 tacrine 100.86 µM 2.32188440091496 0.0154813471494953 no 76 0.0101195804874767 120 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1510 1123-0200 71.5 µM 2.31762159598611 0.0156370259743383 no 77 0.0102349477300263 194 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1420 4'-methoxyflavone 42 µM 2.31406585555819 0.0157679082701812 no 78 0.0103320550038031 123 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_767 0929-0023 86 µM 2.30777008743232 0.0160019527809234 no 79 0.010505963740539 265 1204563 SGTC_1631 benzylvanillin 81.9 µM 2.30244007431421 0.0162024169816793 no 80 0.010655183607299 160 75506 SGTC_893 0958-0369 48.9 µM 2.29395435248362 0.0165260073862426 no 81 0.0108965604422416 175 6819948 SGTC_316 k060-0003 58.6 µM 2.2810298833355 0.0170294857230047 no 82 0.0112733393100394 135 6152314 SGTC_79 0052-0007 94.094 µM 2.2787597385318 0.0171192606705446 no 83 0.011340675719475 160 2801472 SGTC_284 0988-0104 32.6 µM 2.2764117877488 0.0172125377068661 no 84 0.0114106874070807 135 4666532 SGTC_2543 pimpinellin 60.67 µM 2.27638508188191 0.0172136011434416 no 85 0.0114114858832347 147 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1765 st044815 90.4 µM 2.26977864560227 0.0174784020083285 no 86 0.0116105084285839 149 645695 SGTC_421 streptovitacin 30 mM 2.26932507301942 0.0174967091233491 no 87 0.0116242824455443 168 91467 include heat shock SGTC_2084 5306078 60.6385 µM 2.26787956285617 0.0175551621245122 no 88 0.0116682741544288 154 679340 SGTC_2066 5222451 176 µM 2.25837831923987 0.0179435336229648 no 89 0.0119610416151015 214 2281147 SGTC_208 k072-0098 12.366 µM 2.25673638733432 0.0180113861474525 no 90 0.0120122758594804 235 5948901 SGTC_1682 st012968 530 nM 2.24462582138975 0.0185186424207395 no 91 0.0123960818392135 139 24207270 SGTC_548 1436-0017 110 µM 2.24394038122276 0.0185477125261035 no 92 0.0124181187638246 196 9677137 SGTC_1231 0242-0792 125 µM 2.2416725901546 0.0186441685744389 no 93 0.0124912703201662 155 3707635 SGTC_2828 7998861 71.43 µM 2.23743742319712 0.0188254466417099 no 94 0.0126288824650021 122 2988188 SGTC_1119 parthenolide 318.541 nM 2.23599623509964 0.0188874749096587 no 95 0.0126760088882285 229 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3027 9089541 49.47 µM 2.22905038714044 0.0191888656628863 no 96 0.0129052762067322 176 9943819 SGTC_1968 st069590 43.6 µM 2.22534825777499 0.019351170162949 no 97 0.013028934091007 144 6384066 SGTC_501 nsc-95397 161 µM 2.22261887303664 0.0194715744175091 no 98 0.0131207552475284 120 262093 SGTC_3164 9100705 49.47 µM 2.21485899107938 0.0198173763341672 no 99 0.0133848723265736 103 17174235 SGTC_1128 3448-9350 235 µM 2.19847792818932 0.020564503466578 no 100 0.0139575328738446 181 619386 SGTC_791 1348-1292 225 µM 2.19793039645635 0.0205898825802066 no 101 0.0139770331994823 238 5437054 SGTC_795 0685-0265 78 µM 2.19067810219513 0.0209285506946941 no 102 0.0142375474086716 189 302754 SGTC_2707 st078556 66.6 µM 2.19001088275253 0.0209599440520735 no 103 0.0142617237864261 129 17250899 SGTC_540 1187-0821 17.3 µM 2.18442515527275 0.0212243250237373 no 104 0.0144655107218026 177 847520 SGTC_1527 coumarin 137 µM 2.18405626738038 0.0212418838969917 no 105 0.0144790568468062 173 323 A hepatotoxic, DNA x-linker. SGTC_3293 9120939 62.045 µM 2.1817893031678 0.0213500601818111 no 106 0.0145625432008546 159 934087 SGTC_2263 7948595 193.29 µM 2.17685914975013 0.0215869289089968 no 107 0.0147455390751677 116 2971371 SGTC_2504 purpurogallin 52.29 µM 2.15992950122173 0.0224172862223584 no 108 0.0153890637777692 178 5281571 An antioxidant. SGTC_2585 alliin 100 µM 2.15041742351129 0.0228955383964014 no 109 0.0157611056802626 206 87310 A garlic compound which reacts with lipids. SGTC_56 0957-0365 83.25 µM 2.14972814934849 0.0229305255201226 no 110 0.0157883622382159 213 6752360 SGTC_413 propylparaben 100 µM 2.14972636732674 0.0229306160327648 no 111 0.0157884327585883 154 7175 A pharmaceutical preservative. SGTC_594 1487-1584 10.8 µM 2.14285569237167 0.0232818367984425 no 112 0.0160623438569825 184 5013332 SGTC_745 0469-0705 296 µM 2.13692662704736 0.0235885528397318 no 113 0.016301979947475 213 3486736 SGTC_2866 9034245 58.44 µM 2.13266612211784 0.0238110452391389 no 114 0.0164760624496293 134 6462273 SGTC_150 3970-0969 77.2 µM 2.11662453904362 0.0246646585372639 no 115 0.0171458628958382 273 6615640 SGTC_2678 equilin 100 µM 2.11589933718139 0.0247038472999547 no 116 0.0171766849135214 190 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.11239863568206 0.0248937551093614 no 117 0.017326135965218 273 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3248 9135562 49.47 µM 2.10904020257448 0.0250770941922858 no 118 0.0174705558126481 162 17650701 SGTC_2248 tofa 1.1 µM 2.10786423974683 0.0251415577420706 no 119 0.0175213671141161 188 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_529 4076-0302 30.3 µM 2.10593023098435 0.0252478776161434 no 120 0.0176052066118117 192 5816522 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.10246763813578 0.0254391706595715 no 121 0.0177561658065288 188 6312947 SGTC_869 0564-0080 44.1 µM 2.10156512574788 0.0254892294638936 no 122 0.0177956937386439 214 6843321 SGTC_1716 st033144 30.6155 µM 2.09881430913032 0.0256423155770045 no 123 0.0179166364793136 188 674617 SGTC_266 formosanin C 406 nM 2.09728662247706 0.0257276650216688 no 124 0.0179841051800748 247 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1054 3429-0080 167 µM 2.08917394587027 0.0261849011510715 no 125 0.0183460339265034 217 1162877 SGTC_2545 solidagenone 89.61 µM 2.07930033503224 0.0267505322910358 no 126 0.0187948771805363 76 6708572 An anti ulcer agent SGTC_1513 0337-0559 19 µM 2.07008466519378 0.0272876429932149 no 127 0.0192222083273938 210 775073 SGTC_2862 9027634 71.43 µM 2.05017508448339 0.0284787705241455 no 128 0.0201736742132893 204 5012562 SGTC_682 0kpi-0099 17 µM 2.048348852056 0.0285901617078558 no 129 0.0202629147108329 256 1714895 YML126C ERG13 SGTC_1989 st071868 50.2 µM 2.04120789501741 0.0290292094968696 no 130 0.0206150836540144 217 16414057 SGTC_2782 7736369 71.43 µM 2.03315929354716 0.0295307633295537 no 131 0.0210182160749676 255 2950836 YOL077C BRX1 SGTC_2532 xanthone 78.9 µM 2.02833283347918 0.0298349626106768 no 132 0.0212631450533683 206 7020 An insecticide. SGTC_203 k066-0004 30.888 µM 2.00735895256207 0.0311872368565086 no 133 0.0223557280785547 269 6795412 SGTC_391 gliotoxin 8.33 µM 2.00453561857407 0.0313730819830096 no 134 0.0225063576939983 260 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1841 st054148 70 µM 1.99860809885194 0.0317662393270995 no 135 0.0228253867107622 201 675442 SGTC_2391 6285546 200 µM 1.99052767681264 0.0323087414010705 no 136 0.0232664191462152 269 846083 SGTC_575 k072-0246 11.9 µM 1.98334783287165 0.0327971742507023 no 137 0.0236642949494599 227 6796779 SGTC_2015 5119600 184 µM 1.98152555648528 0.0329221046080551 no 138 0.0237661831366773 233 2828786 SGTC_2506 ethyl hematommate 54.16 µM 1.97512374206586 0.0333641087380718 no 139 0.0241270535635844 196 3940691 An allergen. SGTC_2252 omeprazole 400 µM 1.97222833466662 0.0335656167996774 no 140 0.0242917732289529 127 4594 A proton pump inhibitor. SGTC_1567 st069303 68.4 µM 1.96628040288517 0.033982710748323 no 141 0.0246331146335774 243 5581319 SGTC_3095 9117207 49.47 µM 1.96420226138952 0.0341294398009075 no 142 0.0247533203401507 160 17015229 SGTC_763 3453-1109 128 µM 1.96103414510001 0.0343541294874688 no 143 0.0249375199514153 231 1560353 SGTC_3315 9136395 68.55 µM 1.9610129538435 0.0343556365003025 no 144 0.0249387559058013 221 16876844 SGTC_288 1315-0019 35.1 µM 1.95409822283041 0.0348502854189684 no 145 0.0253448011175524 243 6811474 SGTC_565 1418-0001 44.5 µM 1.9530667148049 0.0349245736026435 no 146 0.0254058452126413 271 2862145 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.95081287722149 0.0350873450863413 no 147 0.025539654721502 250 4174840 SGTC_2701 st077767 14.721 µM 1.9472827415987 0.035343541097218 no 148 0.0257504233127326 288 5721188 SGTC_968 1309-0633 340 µM 1.94647835379244 0.0354021328417875 no 149 0.0257986528243304 222 3761976 SGTC_337 1315-0038 354 µM 1.945254103858 0.0354914602630533 no 150 0.0258722015107792 225 1626437 SGTC_1820 st053765 18.6 µM 1.94379827714188 0.0355979251429569 no 151 0.0259598908092497 222 3690829 SGTC_2863 9028737 58.44 µM 1.91627219989652 0.0376606560050415 no 152 0.0276652287541791 175 6460917 SGTC_1923 st058458 19.1 µM 1.91314424720908 0.0379011094265965 no 153 0.0278647943012412 292 3534982 SGTC_2657 nystatin 74.44 µM 1.90201393258521 0.0387669024624776 no 154 0.0285846665815746 242 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1509 1326-1131 80 µM 1.90085919581493 0.0388576410137991 no 155 0.028660228981254 207 768313 SGTC_50 0929-0078 56.389 µM 1.89837685467806 0.0390532875899577 no 156 0.0288232281687796 275 1377751 SGTC_2946 9065502 71.43 µM 1.8976072203598 0.0391141091996779 no 157 0.0288739212853974 135 16489101 SGTC_1845 st056753 3.01 µM 1.89238191834054 0.0395290889302205 no 158 0.0292200567045858 286 5375839 SGTC_958 1222-0007 33 µM 1.88924377971583 0.039780028054893 no 159 0.0294295854662023 279 7312461 SGTC_608 k048-0125 159 µM 1.88075127599597 0.0404656252283804 no 160 0.0300028804771193 252 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2780 5215298 71.43 µM 1.87265658298551 0.0411280070416126 no 161 0.0305579112033828 294 2834131 SGTC_249 wiskostatin 11.211 µM 1.86798959197728 0.041513881335557 no 162 0.0308817608412458 218 2775510 A n-wasp and actin depolymerizer. SGTC_933 2914-0560 114 µM 1.86673576967898 0.0416180477772284 no 163 0.0309692479927021 286 463887 SGTC_179 1273-0063 6.77 µM 1.85284582537335 0.0427862350188796 no 164 0.0319522299381426 237 3108139 SGTC_2524 avocatin b 10.57 µM 1.84979052262204 0.043046718974545 no 165 0.0321718736818928 225 6710748 SGTC_1332 1480-0653 17.5 µM 1.84975108515978 0.0430500896251319 no 166 0.0321747169429037 265 5749438 SGTC_1065 prochlorperazine maleate 2.48 µM 1.83788792765145 0.044073731969995 no 167 0.0330394606934514 280 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1757 st041620 31.8375 µM 1.83487907549264 0.0443364545172558 no 168 0.0332618043353805 275 5289815 SGTC_934 2950-0684 338 µM 1.83399789194097 0.0444136348974623 no 169 0.0333271535366059 282 1121253 SGTC_3047 9092122 49.47 µM 1.82733193382475 0.0450010003430769 no 170 0.0338249383013044 273 17173831 SGTC_418 lividomycin a 100 µM 1.82362848157173 0.0453300190425434 no 171 0.0341041288475968 252 72394 An antibiotic. SGTC_2794 7785382 27.27 µM 1.81803612566888 0.0458305142278346 no 172 0.0345293057281875 373 2205081 SGTC_2955 9076254 12.21 µM 1.81364072837783 0.0462269948976589 no 173 0.034866527881461 244 16459619 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.81106582029745 0.0464605373321504 no 174 0.0350653318025783 264 4213774 SGTC_959 1222-0044 107 µM 1.80703083545171 0.0468284116505835 no 175 0.0353787357443277 285 6083612 SGTC_1388 3346-4487 254 µM 1.80518570197156 0.0469974113546217 no 176 0.0355228137918373 304 3345614 SGTC_3354 9151612 71.43 µM 1.80517319078369 0.0469985589480828 no 177 0.035523792372876 285 27261949 SGTC_2053 5265679 138 µM 1.80304537127611 0.0471940611183531 no 178 0.0356905447219693 313 764595 SGTC_1338 1486-1223 76 µM 1.79942167442989 0.0475285030675769 no 179 0.0359760017790725 289 3444526 SGTC_11 0438-0307 1.3 µM 1.79331996794133 0.0480959355253661 no 180 0.0364608881714961 243 4011476 SGTC_285 1486-1325 46 µM 1.78363528584944 0.0490076868690999 no 181 0.0372414739990302 305 22310230 SGTC_1961 st076550 68.7 µM 1.783581409676 0.0490127973218652 no 182 0.0372458543130984 248 1579337 SGTC_732 3970-1727 52.7 µM 1.78332799720462 0.0490368406060183 no 183 0.0372664632459605 248 1275699 SGTC_290 2043-6722 48.1 µM 1.7813648835095 0.0492234163820103 no 184 0.0374264305606644 267 773758 YLR208W SEC13 SGTC_2076 5212012 200 µM 1.78079229758126 0.0492779420281198 no 185 0.0374731941007253 194 604802 SGTC_1656 st012921 11 µM 1.77523710060206 0.049809454071414 no 186 0.0379293730987778 247 6732821 SGTC_194 1486-1323 56.904 µM 1.7682157394592 0.0504877780197118 no 187 0.0385124219525978 280 5178754 SGTC_1708 st033234 31.827 µM 1.7635649401927 0.0509411230102799 no 188 0.0389026274040073 313 674664 SGTC_2831 7999036 19.48 µM 1.7596259049955 0.0513276168493421 no 189 0.0392356281427986 337 2988270 SGTC_2742 clothiapine 36.27 µM 1.75860700213974 0.0514279692724617 no 190 0.0393221414207558 227 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3205 9113483 49.47 µM 1.75797752444684 0.0514900448924783 no 191 0.0393756668083803 341 17018033 SGTC_2932 9016711 44.54 µM 1.75204100497602 0.0520784067033942 no 192 0.0398833786544717 346 7117328 SGTC_3316 9136639 10.545 µM 1.75148995130635 0.0521332908065841 no 193 0.0399307753521148 279 4903665 SGTC_2081 5214970 32.255 µM 1.74668694084312 0.0526136108564587 no 194 0.04034582843817 283 2063512 SGTC_61 0978-8327 98.565 µM 1.74028834991303 0.0532589434630346 no 195 0.0409041993396521 321 6150059 YHR072W ERG7 SGTC_2890 9046729 58.44 µM 1.73666705386316 0.0536269416982545 no 196 0.0412229781498701 273 903329 SGTC_1910 st062352 60.4 µM 1.73631987670626 0.0536623275955356 no 197 0.0412536452949203 344 2245730 SGTC_775 4577-0580 57.3 µM 1.73574948844581 0.053720504349514 no 198 0.0413040694623259 291 2006902 SGTC_3297 9117502 71.43 µM 1.73131419121 0.054174588579246 no 199 0.0416978708552943 250 7453720 SGTC_57 miconazole 162.5 nM 1.72934847630081 0.054376806768997 no 200 0.0418733727440795 291 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1200 1643-0193 18.4 µM 1.7289507331988 0.0544177961756811 no 201 0.041908956478198 320 5403974 SGTC_1721 st082152 9.2685 µM 1.72299471986115 0.0550345207215777 no 202 0.0424447399445156 284 5296051 SGTC_994 3910-0338 138 µM 1.7201988216252 0.0553259246419897 no 203 0.0426981535839969 358 3479481 SGTC_2096 5468907 200 µM 1.71797095540951 0.055558996322952 no 204 0.0429009565702288 292 759785 SGTC_1882 5615643 20 µM 1.71633357558924 0.0557307869721359 no 205 0.0430505032084655 274 2253075 SGTC_2967 9089538 49.85 µM 1.71543537437094 0.0558252023501779 no 206 0.0431327172314517 354 728216 SGTC_2158 5657123 3.6195 µM 1.71486410546093 0.0558853175188679 no 207 0.0431850724816474 270 2858827 SGTC_2757 clomiphene 4.22 µM 1.71174362579864 0.0562145904162186 no 208 0.0434719625745757 366 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_670 4204-0025 119 µM 1.71121792640475 0.0562702124455215 no 209 0.0435204453127377 339 719039 SGTC_41 0478-0632 82.643 µM 1.71043217097241 0.0563534307860753 no 210 0.0435929931328356 380 3750424 SGTC_1522 st012842 45.6 µM 1.7088148260418 0.0565250270194482 no 211 0.0437426277706638 309 3491067 YOR116C RPO31 SGTC_1087 pterostilbene 9.05 µM 1.70772212357718 0.0566411928783396 no 212 0.0438439575361719 343 5281727 Similar to reservatol, lowers cholesterol. SGTC_276 colchicine 750 µM 1.70580913409096 0.0568450167320338 no 213 0.0440218109647408 348 2833 A microtubule depolymerizer. SGTC_2785 7756463 72.73 µM 1.70471684160188 0.0569616563550867 no 214 0.0441236236392479 318 2201551 SGTC_3305 9127027 53.8275 µM 1.70390896437573 0.0570480460792742 no 215 0.0441990480054569 314 41905295 SGTC_3318 9139014 38.6185 µM 1.6936712100286 0.0581517701764984 no 216 0.045163889076929 296 16643984 SGTC_2378 9074213 121.43 µM 1.69336991761254 0.0581845046410781 no 217 0.0451925386000748 348 657714 SGTC_2477 5967686 25.23 µM 1.68447596626976 0.05915734097607 no 218 0.0460448602003331 345 776118 SGTC_2056 5235370 200 µM 1.68355203045668 0.0592591298967967 no 219 0.046134137973984 350 5511916 SGTC_1779 st039427 55 µM 1.67862037814937 0.0598047689764926 no 220 0.0466130262225355 394 1124498 SGTC_1967 st070177 51.4 µM 1.67736920852373 0.0599438226744435 no 221 0.04673515333592 294 5729214 SGTC_2346 9031566 143.75 µM 1.67260325068843 0.0604758268281154 no 222 0.0472027132746064 301 4771086 SGTC_2772 vinpocetine 57.06 µM 1.67039773827868 0.0607232661281704 no 223 0.0474203484220489 350 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1093 fluphenazine 7.97 µM 1.66920077586735 0.0608578859761766 no 224 0.0475387982048299 380 6602611 An atypical antipsychotic. SGTC_1284 0929-0043 16 µM 1.66590460729509 0.0612298053755212 no 225 0.0478662079132373 362 1239883 SGTC_2162 5663267 200 µM 1.6618359481554 0.0616913342835104 no 226 0.0482728361360371 313 6456493 SGTC_1022 4477-0945 21.3 µM 1.65322544636517 0.0626770206877128 no 227 0.0491424947477668 368 4648966 SGTC_2335 9018011 154.17 µM 1.65129174120042 0.0629000602290263 no 228 0.0493395089309358 381 6458208 SGTC_1103 duloxetine 36.1 µM 1.64969835508041 0.0630843106022033 no 229 0.0495023234060674 400 60835 A selective serotonin reuptake inhibitor. SGTC_2975 9084847 53.72 µM 1.64956654903651 0.0630995707294916 no 230 0.0495158107172654 366 27211724 SGTC_2746 daunorubicin 9.88 µM 1.64500558399846 0.0636293992405986 no 231 0.0499843297711559 200 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_950 1165-0508 94.1 µM 1.64312988458604 0.0638482934077638 no 232 0.0501780314519674 359 6148369 SGTC_91 0417-1751 58.384 µM 1.64102402995177 0.0640947440979394 no 233 0.0503962135615677 452 6795624 SGTC_3236 9132701 49.47 µM 1.63941729027929 0.0642832796790043 no 234 0.050563191566764 329 24282524 SGTC_1573 oleylamine 1.06 µM 1.63883808467335 0.0643513495262499 no 235 0.0506234925990185 371 5356789 An amine of the fatty acid oleic acid. SGTC_2626 ethyl orsellinate 100 µM 1.63470631927973 0.0648385521135101 no 236 0.0510553135734119 323 75653 A natural product. SGTC_728 3030-5151 22.5 µM 1.63015542590818 0.0653784858878246 no 237 0.0515343259639625 312 3125388 SGTC_691 1548-0686 185 µM 1.62856421945286 0.0655680928646604 no 238 0.051702651986621 397 46495133 SGTC_3173 9105693 49.47 µM 1.62766926958686 0.0656749216174538 no 239 0.0517975162587947 381 17096658 SGTC_3356 9151811 4.48 µM 1.6275909997952 0.0656842709719315 no 240 0.0518058193947186 353 1859254 YPR165W RHO1 SGTC_1004 4084-0029 199 µM 1.62592371534588 0.0658836738820998 no 241 0.0519829422183843 381 716894 YLR208W SEC13 SGTC_3018 9082602 49.47 µM 1.62158628601779 0.0664046169616457 no 242 0.0524459804986618 376 17332089 SGTC_751 0833-0568 350 µM 1.61895425096629 0.0667222865894156 no 243 0.0527285534280084 341 6954252 SGTC_918 glabranin 770.725 nM 1.61887451324079 0.0667319287388147 no 244 0.0527371328144147 383 124049 Also referred to as licorice root. SGTC_606 k015-0008 38.6 µM 1.61384595745512 0.067342179175352 no 245 0.053280421627333 388 1970475 SGTC_464 bw-b 70c 158 µM 1.61286203635723 0.0674620879281259 no 246 0.0533872423222681 408 5353454 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.61254419486845 0.0675008579579875 no 247 0.0534217854492053 359 6710655 SGTC_1024 4507-0395 26 µM 1.61172923226965 0.0676003450643132 no 248 0.0535104368062746 358 4201836 SGTC_1136 pergolide 1.05886 µM 1.60003721575964 0.0690401585217797 no 249 0.0547951638193357 490 47811 A dopamine receptor agonist. SGTC_2570 licareol 100 µM 1.59818477702981 0.069270430146281 no 250 0.0550009303093755 366 443158 SGTC_2861 9024595 19.48 µM 1.59764301293215 0.0693378870716363 no 251 0.0550612240165966 241 16482810 SGTC_1669 st015249 58.4 µM 1.59559137366051 0.0695938025077832 no 252 0.0552900273674706 322 722793 SGTC_2747 doxorubicin 7.63 µM 1.59371241973197 0.0698288151201358 no 253 0.0555002306002608 221 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1283 0922-0125 16.4 µM 1.59154291132927 0.070100928446292 no 254 0.0557437231160193 400 3360884 SGTC_899 1083-0020 478 µM 1.59123800750187 0.0701392366806504 no 255 0.055778011138092 400 767123 SGTC_1579 chlormadinone acetate 49.4 µM 1.58479533838928 0.0709524663424967 no 256 0.0565064209466576 382 45114258 A steroidal progestin. SGTC_764 1951-2361 146 µM 1.57865862540224 0.0717337927784923 no 257 0.0572071898982766 392 5438930 SGTC_2953 9074162 66.49 µM 1.57841287799444 0.0717652182342737 no 258 0.0572353943018742 319 16451992 SGTC_1664 st014217 9.02 µM 1.57594369072755 0.0720815569720221 no 259 0.0575193904025561 382 3982782 SGTC_2886 9058944 51.95 µM 1.57130541479457 0.0726786759660029 no 260 0.0580558620340186 194 4949929 SGTC_1889 st059080 5.18 µM 1.56953937697394 0.0729070239801205 no 261 0.0582611558503698 407 176925 Isolated from Daphnopsis sellowiana. SGTC_1458 k015-0034 6.33 µM 1.56931819613579 0.0729356612334371 no 262 0.058286907244093 364 3598957 SGTC_450 aminopyrene 156 nM 1.56749622006672 0.0731718881539721 no 263 0.0584993745297834 404 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_193 1273-0060 1.558 µM 1.56742577346834 0.0731810335952444 no 264 0.0585076017601722 287 2847393 YHR072W ERG7 SGTC_185 k048-0037 25.491 µM 1.56628035364733 0.073329855778322 no 265 0.0586414991540947 376 6827589 SGTC_412 gemfibrozil 100 µM 1.56248908639455 0.0738240993233712 no 266 0.0590864074423632 313 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2933 9026794 32.47 µM 1.56218375208512 0.0738640143372616 no 267 0.0591223535641999 425 17586027 SGTC_3031 9088762 49.47 µM 1.56162889856222 0.0739365901160818 no 268 0.0591877187609429 401 205253 SGTC_2595 hexamethylquercetagetin 100 µM 1.56140646332037 0.0739657003177174 no 269 0.0592139389253136 364 386331 SGTC_1907 st060210 83.7 µM 1.56105619637574 0.0740115576641002 no 270 0.0592552460668765 435 688793 SGTC_803 4488-1585 147 µM 1.55938189701784 0.0742310589623658 no 271 0.0594530091887749 343 747204 SGTC_3240 9133527 49.47 µM 1.5588497499597 0.0743009276701301 no 272 0.0595159730093204 366 17617455 SGTC_1398 3558-0053 112 µM 1.55493174989738 0.0748168917585063 no 273 0.0599811623878578 309 4532369 SGTC_1377 2944-0135 198 µM 1.55114284026455 0.0753184515021315 no 274 0.0604337283169855 422 1894137 SGTC_2522 biochanin a 4.94 µM 1.54691017479236 0.0758817801749964 no 275 0.0609424536040696 357 5280373 A possible chelator. SGTC_3133 9127736 49.47 µM 1.54388232750794 0.0762867232179329 no 276 0.0613084210520037 393 27243420 SGTC_2377 9073351 62.6 µM 1.54287245403887 0.0764221483551346 no 277 0.0614308627478236 385 7337946 YHR072W ERG7 SGTC_1044 1222-0021 1.78 µM 1.53994862536908 0.0768152683697478 no 278 0.0617864383729899 414 4306703 SGTC_992 3909-8734 162 µM 1.53945322922704 0.0768820283371718 no 279 0.0618468438474457 387 4288319 SGTC_2910 7948405 25.97 µM 1.53758848557887 0.077133718166371 no 280 0.0620746322910075 349 2971328 SGTC_1422 4031-0024 15.5 µM 1.53398063760971 0.077622456661165 no 281 0.0625172081298543 395 782427 SGTC_2620 irigenin 100 µM 1.53173661754174 0.0779276275009203 no 282 0.0627937212231292 432 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1210 3013-0140 750 nM 1.53163709835157 0.0779411824592519 no 283 0.0628060062309625 399 905973 SGTC_1675 st018485 24.5 µM 1.52844609023519 0.0783767610209982 no 284 0.0632009093890402 396 3323024 SGTC_858 0438-0351 2.77 µM 1.52699666003004 0.0785752194830197 no 285 0.0633809209506088 430 2799119 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.52694080489721 0.0785828748781711 no 286 0.0633878658406072 266 88881 An O-methylated flavonoid and antioxidant. SGTC_2568 diosmetin 100 µM 1.52080096265244 0.0794278407389088 no 287 0.0641548963944993 437 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2000 st075254 36.4 µM 1.52073208094602 0.0794373590999618 no 288 0.0641635423072398 357 17234175 SGTC_384 k007-0144 5.16 µM 1.52022619493195 0.0795072909899912 no 289 0.0642270680010893 480 6824886 SGTC_2467 5474540 200 µM 1.52021271104941 0.0795091555913573 no 290 0.0642287618831309 421 5413519 SGTC_643 k048-0106 28.4 µM 1.51949740483022 0.0796081182396106 no 291 0.0643186703866587 399 6763920 SGTC_2515 chrysin 20.77 µM 1.51563940080005 0.0801434807383582 no 292 0.0648052792204853 386 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3238 9133470 49.47 µM 1.51512468422973 0.0802151115394075 no 293 0.0648704158146735 375 3534688 SGTC_2032 5185112 25.99 µM 1.5127020641702 0.0805529067106074 no 294 0.0651776775164238 380 5718189 SGTC_630 4356-0227 183 µM 1.51162622657746 0.0807032589370342 no 295 0.0653144879294334 391 779312 SGTC_697 0508-1955 564 µM 1.50827758860638 0.0811725997500237 no 296 0.0657417483235058 461 6243113 SGTC_2433 5607874 27.82 µM 1.50752526749507 0.0812783268888476 no 297 0.0658380361001724 429 2252428 SGTC_2587 piperic acid 92.2 µM 1.50482928549852 0.0816580589104525 no 298 0.0661839862368526 390 5370536 SGTC_114 0364-0001 490.298 µM 1.50405324471442 0.0817676126390725 no 299 0.0662838288236835 430 4003655 SGTC_2958 9077254 16.72 µM 1.50262557138668 0.0819694467100457 no 300 0.0664678127212495 384 16457351 SGTC_1694 st024011 44.9 µM 1.49891317938717 0.0824960347054429 no 301 0.0669480784337844 452 2787533 SGTC_334 1502-1024 68.5 µM 1.49294467132275 0.08334797638777 no 302 0.0677258352493301 434 3296216 SGTC_3139 9095020 49.47 µM 1.48739156450161 0.0841465473844383 no 303 0.0684557117648421 299 25236292 SGTC_3207 9114163 49.47 µM 1.48499283443201 0.0844932705331639 no 304 0.0687728611369686 482 849233 SGTC_1148 3909-7663 27.7 µM 1.47956082437981 0.0852823975916767 no 305 0.0694952439128518 439 4084526 SGTC_1503 4585-0012 61.3 µM 1.47512159091966 0.0859313902141543 no 306 0.0700899283530768 399 2922052 SGTC_89 0302-0250 142.109 µM 1.47295264300163 0.0862498198639981 no 307 0.0703819028573001 473 4203518 YLR208W SEC13 SGTC_1456 k015-0012 13 µM 1.46778977849922 0.0870113446861988 no 308 0.071080667408736 493 2989616 SGTC_1372 2752-0194 270 µM 1.46512704333115 0.0874060570361733 no 309 0.0714431298299704 423 823334 SGTC_2310 7668677 200 µM 1.45992912136929 0.0881804230005518 no 310 0.0721547773660005 449 2197143 SGTC_1802 st050112 57.9 µM 1.45950534152163 0.088243780805501 no 311 0.0722130357708056 449 4662563 SGTC_1272 0839-0021 27 µM 1.45112919543754 0.089503040611071 no 312 0.0733719441077169 462 5027250 SGTC_644 1498-1197 63.3 µM 1.44787627620627 0.0899956669661865 no 313 0.0738258277900204 486 6741615 SGTC_1519 esterone 74 µM 1.44667119322141 0.0901786768593974 no 314 0.0739945181107209 471 698 A steroid. SGTC_895 0964-0006 13.7 µM 1.4445876469344 0.0904957465173966 no 315 0.0742868723222902 441 6738897 SGTC_2269 7935389 174.42 µM 1.44448163467382 0.0905119013382921 no 316 0.0743017710535109 438 97605 SGTC_655 k060-0012 42 µM 1.44288266367165 0.090755822424437 no 317 0.0745267637824977 455 5994525 SGTC_925 2064-1272 59.6 µM 1.44101560182709 0.0910412573978732 no 318 0.0747901375627568 435 6815817 SGTC_3040 9091894 49.47 µM 1.44016525797688 0.0911714777812136 no 319 0.0749103249281267 391 25236966 SGTC_1997 st073024 93.8 µM 1.43887198612691 0.0913697921975217 no 320 0.0750933979708982 435 686268 SGTC_1755 st041960 45.185 µM 1.43846147970275 0.0914328073696778 no 321 0.0751515797404935 442 2257073 SGTC_3090 9117696 49.47 µM 1.43709731183334 0.091642446626223 no 322 0.075345172477049 411 7923821 SGTC_1736 st036774 51 µM 1.43643533163942 0.0917443050551643 no 323 0.0754392527505749 477 1272247 SGTC_2101 5377231 179.231 µM 1.43547569205913 0.0918921130089568 no 324 0.0755757951477361 425 2844213 SGTC_38 0929-0051 58.268 µM 1.43511113761845 0.0919483095061329 no 325 0.0756277151323865 496 1379719 SGTC_2449 5812982 45.77 µM 1.43192131339843 0.092441110665419 no 326 0.0760831709072051 415 776185 SGTC_1906 st060206 94.7 µM 1.42896185681542 0.0929000671209163 no 327 0.0765075984182457 490 5133468 SGTC_2178 5812956 200 µM 1.42861971350716 0.0929532356106273 no 328 0.0765567824787394 426 5403383 SGTC_1010 4112-3296 15.2 µM 1.42845940498219 0.0929781550212996 no 329 0.0765798355515512 494 704384 SGTC_2320 7373003 200 µM 1.42679528969674 0.0932371278096786 no 330 0.0768194546484338 443 5415828 SGTC_2226 7298446 200 µM 1.42631759339478 0.0933115661831143 no 331 0.0768883442341035 394 3283010 SGTC_2647 atorvastatin 60.16 µM 1.42098737598342 0.0941451425330324 no 332 0.0776602147343606 446 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_408 cantharidin 100 µM 1.41790394363298 0.0946298523815633 no 333 0.0781094054406691 500 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3213 9129884 49.47 µM 1.41283593332023 0.0954305265875564 no 334 0.0788519850518948 405 17190742 SGTC_2783 7738165 71.43 µM 1.41111967227908 0.0957027987847105 no 335 0.0791046651669348 370 17201110 SGTC_2004 4023728 41.89 µM 1.40670292455256 0.0964061105199178 no 336 0.0797577490896974 496 360084 YDR527W RBA50 SGTC_1058 3448-5425 97.3 µM 1.40304768101738 0.0969910285527455 no 337 0.0803013105058118 467 7279705 SGTC_1375 2910-0797 186 µM 1.40255801641515 0.0970695829303871 no 338 0.0803743393312168 482 742508 SGTC_747 3448-8087 38.7 µM 1.40133875983001 0.0972653848851896 no 339 0.0805563979070757 511 5168703 SGTC_124 0136-0217 7.121 µM 1.40056597734052 0.0973896369552023 no 340 0.0806719504501992 567 3976905 SGTC_1109 tnp00067 928.257 nM 1.39902481518402 0.0976377807668647 no 341 0.0809027708790487 478 676295 SGTC_2030 5175110 200 µM 1.39689265852524 0.0979818450179094 no 342 0.0812229263084971 469 2831986 SGTC_2985 9022375 71.43 µM 1.3966843486508 0.0980155073831873 no 343 0.0812542564041705 496 4939335 SGTC_3009 9080819 71.4286 µM 1.39540350760857 0.0982226744225074 no 344 0.0814470970950928 470 17027216 SGTC_3002 9075603 71.4286 µM 1.39532453707075 0.0982354578415838 no 345 0.0814589980177767 502 20105405 SGTC_1345 1488-0192 31.4 µM 1.39462338063221 0.0983490115499683 no 346 0.0815647203701215 493 658348 SGTC_653 0203-0016 55.2 µM 1.39226698498465 0.098731338966381 no 347 0.0819207825607927 484 295302 SGTC_2815 7968870 71.43 µM 1.39154457555772 0.0988487681479959 no 348 0.0820301761936891 526 2977326 YHR190W ERG9 SGTC_2793 7325131 81.82 µM 1.38853431802885 0.0993391921018587 no 349 0.0824872011044775 441 4176441 SGTC_2858 9025781 8.96 µM 1.38711917265105 0.0995703579136748 no 350 0.0827027133112353 614 4894980 YPL153C RAD53 SGTC_754 3474-0146 171 µM 1.38495151000004 0.0999252102526045 no 351 0.0830336474602799 456 24762078 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.38237702387082 0.100347859517684 no 352 0.0834279835436892 560 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1740 st038286 13.222 µM 1.37846555215191 0.100992494053058 no 353 0.084029798224503 498 716786 SGTC_2745 rifampicin 24.3 µM 1.37824932803885 0.101028216960685 no 354 0.0840631610503799 328 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3125 9127534 49.47 µM 1.3759496287979 0.101408725873731 no 355 0.0844186143254353 382 1639235 SGTC_1374 2889-5571 141 µM 1.37478235954152 0.101602261530477 no 356 0.084599464340082 542 2853281 SGTC_465 cgp-37157 41 µM 1.3742299312015 0.101693949000977 no 357 0.0846851556680517 345 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1775 st081588 35.1725 µM 1.36978684257723 0.102433567384086 no 358 0.0853767252256211 545 1426443 YGL099W LSG1 SGTC_536 3852-0578 10.6 µM 1.36685399300072 0.102923922315429 no 359 0.0858355375181392 488 2869208 SGTC_1609 st001574 46.4 µM 1.36551680511178 0.103148057292183 no 360 0.0860453374469267 508 3960012 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.36506128246817 0.103224491363232 no 361 0.0861168948390482 524 688751 SGTC_2928 9011484 9.79 µM 1.36473054058072 0.103280013708757 no 362 0.0861688784929457 460 2994751 SGTC_1571 st070080 73.4 µM 1.36467250898767 0.103289757831551 no 363 0.0861780019054386 498 4315245 SGTC_2289 7946404 165.07 µM 1.36201351300174 0.103736947793923 no 364 0.0865968102980982 603 1246120 YPR165W RHO1 SGTC_3320 9137005 35.139 µM 1.35869151791768 0.104297612373368 no 365 0.0871221805128859 475 4908713 SGTC_2412 st077135 33.4 µM 1.35832599840359 0.104359436224072 no 366 0.087180132109233 509 13258915 SGTC_2738 aclarubicin 5.55 µM 1.35737786116947 0.104519927624965 no 367 0.0873305894840553 389 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1400 3771-8998 51.5 µM 1.35593346525913 0.104764764411529 no 368 0.0875601692891333 468 670767 SGTC_2625 euphol 100 µM 1.35522125931173 0.104885641848718 no 369 0.0876735366598246 549 6708538 A triterpene alcohol. SGTC_127 0180-0333 59.125 µM 1.3546234076042 0.104987188720485 no 370 0.0877687858923865 607 771601 SGTC_1162 k048-0130 20.1 µM 1.35102513675422 0.10559986902292 no 371 0.0883436903397794 510 6797406 SGTC_3144 9087057 49.47 µM 1.35102354465285 0.105600140682243 no 372 0.0883439453332959 508 17249618 SGTC_652 0437-0092 114 µM 1.3490544937599 0.105936505581247 no 373 0.0886597316741621 482 3091274 SGTC_2122 5258151 111.688 µM 1.34196141223743 0.107154604843018 no 374 0.0898042538261215 513 2173356 SGTC_1752 st044819 83.042 µM 1.34037728086073 0.107428023022095 no 375 0.0900613590547529 510 441209 YML126C ERG13 SGTC_1771 st048882 4.1505 µM 1.34028534398549 0.107443906583395 no 376 0.0900762972243669 508 4580403 SGTC_3073 9114972 49.47 µM 1.33690540022186 0.108029021225622 no 377 0.0906267589399646 453 41905075 SGTC_255 tunicamycin 200.472 nM 1.33638853588689 0.108118699394315 no 378 0.0907111557283715 541 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.32994481276317 0.109241214246383 no 379 0.091768227513626 546 5357218 A potent inhibitor of glutathione S-transferases. SGTC_569 4130-2812 160 µM 1.32964512976599 0.109293622885988 no 380 0.0918176106687572 401 743552 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.32829829018391 0.10952938154686 no 381 0.0920397921871795 320 4000243 SGTC_2708 st078559 56 µM 1.32712420321028 0.109735198336502 no 382 0.0922338001132195 406 17250902 SGTC_2014 4013930 200 µM 1.32562257169586 0.10999883791458 no 383 0.0924823729302611 586 64556 SGTC_2329 6138490 200 µM 1.32372117623463 0.110333315202812 no 384 0.0927978314322875 472 720019 SGTC_1359 1582-0056 520 nM 1.32241535161794 0.11056344678113 no 385 0.0930149398207835 584 3661189 SGTC_886 0866-0150 153 µM 1.31904667247885 0.111158713021685 no 386 0.093576754821399 555 271463 SGTC_1813 st051246 8.6015 µM 1.31816385487704 0.111315091105803 no 387 0.0937244012150469 488 5291959 SGTC_164 4100-3994 89.624 µM 1.31554818239861 0.111779343165121 no 388 0.0941628676634986 594 4615967 SGTC_188 3229-0966 278.469 µM 1.31539814703561 0.111806014666962 no 389 0.0941880639762287 628 5722370 SGTC_325 2810-4341 181 µM 1.31205741483333 0.112401069692816 no 390 0.0947503815382745 524 774970 SGTC_1578 josamycin 24.2 µM 1.31051216207262 0.11267707591728 no 391 0.0950113162985061 488 5282165 A P450 substrate. SGTC_4 0960-0234 25.671 µM 1.30665876700669 0.113367459760654 no 392 0.0956643141392148 497 6821112 SGTC_1261 0712-0010 12.7 µM 1.3057655545409 0.113527919751647 no 393 0.0958161486012742 576 2840123 SGTC_2879 9041815 71.43 µM 1.30119573193968 0.114351393347396 no 394 0.0965957329149529 418 4942971 SGTC_496 calpeptin 138 µM 1.29776789960199 0.114971867670323 no 395 0.097183551680219 471 73364 A calpain inhibitor. SGTC_416 estradiol valerate 100 µM 1.28883380723375 0.116600276514721 no 396 0.0987279350493884 528 13791 A steroid. SGTC_1440 4100-1550 40 µM 1.28838053411761 0.116683327960432 no 397 0.098806765716799 499 742806 SGTC_884 0851-0618 334 µM 1.28750170582165 0.116844471682556 no 398 0.098959737711297 599 9642473 SGTC_826 1683-5028 118 µM 1.28497730441915 0.117308228163621 no 399 0.0994001075223528 537 722377 SGTC_3089 9117425 49.47 µM 1.28211016939163 0.11783652745187 no 400 0.099902001043646 524 9401657 SGTC_1053 3366-3204 134 µM 1.28197943592276 0.11786065651285 no 401 0.0999249300483741 588 3632071 YPR165W RHO1 SGTC_1635 st007035 42.4 µM 1.28124285261579 0.117996670690637 no 402 0.100054189321987 749 3716403 SGTC_299 1273-0059 1.44 µM 1.28026741392387 0.118176961661444 no 403 0.100225551950673 540 2848077 SGTC_2488 5268135 45.7 µM 1.277025066028 0.118777646584586 no 404 0.10079669896631 665 1270356 YLR208W SEC13 SGTC_868 0527-0199 213 µM 1.27608576432748 0.118952066022899 no 405 0.100962601646635 585 2849450 SGTC_760 0568-0725 82.9 µM 1.27454181725582 0.119239155229355 no 406 0.101235731229891 582 3916171 SGTC_3322 9139058 2.11 µM 1.27407664177547 0.119325748065061 no 407 0.101318127830202 561 4908926 YPR165W RHO1 SGTC_639 0833-0042 114 µM 1.27268365521741 0.119585319159143 no 408 0.101565159943085 604 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_705 1124-0212 310 µM 1.26942737327782 0.120193652409263 no 409 0.102144339180121 598 9554485 SGTC_2430 5571206 200 µM 1.26327319356102 0.121349313625332 no 410 0.103245508219953 638 1731771 SGTC_3142 9086498 49.47 µM 1.26298469993024 0.121403679395401 no 411 0.103297339151724 542 25236367 SGTC_64 000l-0018 272.079 µM 1.25966444682341 0.122030604104621 no 412 0.103895218033461 683 6811119 SGTC_2215 7188065 200 µM 1.25919305910061 0.122119794730641 no 413 0.103980303992336 509 940217 SGTC_2744 captopril 92.04 µM 1.25908260191391 0.122140700801627 no 414 0.10400024893128 485 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_487 nimodipine 119 µM 1.2579119358031 0.122362425531024 no 415 0.104211803294834 457 4497 L-type voltage-gated calcium channels inhibitor SGTC_161 4065-0411 162.148 µM 1.25522521059931 0.122872360331436 no 416 0.104698508049488 624 1906281 YLR208W SEC13 SGTC_3069 9117009 49.47 µM 1.25423480738327 0.123060712159246 no 417 0.104878335888215 454 41904981 SGTC_2052 5265182 7.135 µM 1.2535812188735 0.123185120402166 no 418 0.104997130587576 613 1239884 SGTC_3081 9117243 49.47 µM 1.24927570241749 0.12400686298455 no 419 0.105782125851219 554 45595589 SGTC_2717 st081029 62.2815 µM 1.24695851611147 0.12445070102977 no 420 0.106206354409212 553 5292846 SGTC_372 0155-0182 15.9 µM 1.24620244917745 0.124595759501037 no 421 0.106345040070055 645 771486 SGTC_910 3454-3003 490 µM 1.24540359654323 0.124749155176137 no 422 0.106491715969435 618 820824 SGTC_977 1348-1378 135 µM 1.24399110916892 0.125020703867936 no 423 0.106751417571301 602 X977 SGTC_167 3672-0051 66.205 µM 1.24209504036847 0.125385869111137 no 424 0.107100749122583 546 3237971 SGTC_1552 6-methylflavone 10.6 µM 1.24118061462477 0.125562244874645 no 425 0.107269517209218 528 689013 SGTC_1707 st032323 6.317 µM 1.2393976905777 0.12590663554077 no 426 0.107599128141439 618 3132057 YMR211W DML1 SGTC_2764 methyldopa 94.69 µM 1.23570824180806 0.126621382213429 no 427 0.108283516434968 620 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3132 9126706 49.47 µM 1.23325019357639 0.127099138760403 no 428 0.108741216935618 561 850858 SGTC_415 dibenzyl ketone 100 µM 1.23323129872396 0.127102816094778 no 429 0.108744740628749 622 7593 SGTC_2662 daunorubicin 22.37 µM 1.22968970634356 0.127793392069591 no 430 0.109406661475559 554 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_302 1094-0063 18.9 µM 1.22647913551003 0.128421671716353 no 431 0.11000921110993 527 5440289 SGTC_808 0711-0032 135 µM 1.22231334942115 0.129240069904249 no 432 0.110794576458772 592 4252555 SGTC_373 0844-0104 25.9 µM 1.21970923646349 0.129753498835958 no 433 0.111287559462205 642 5375804 SGTC_2347 9049783 174.81 µM 1.2193065340713 0.129833021881938 no 434 0.111363934776848 653 6467988 YPL169C MEX67 SGTC_2935 9038016 29.96 µM 1.21929025931827 0.129836236423502 no 435 0.111367022185732 632 6463195 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.21873353700364 0.129946231771247 no 436 0.111472672323417 581 756377 SGTC_2298 7976326 193.81 µM 1.21678961297615 0.130330811633086 no 437 0.111842136513003 531 2235818 SGTC_1921 5740136 50 µM 1.21666912873778 0.130354673744392 no 438 0.111865064658769 667 1774243 SGTC_2994 9053520 71.4286 µM 1.21562524273469 0.130561543693722 no 439 0.112063856861125 607 4647384 SGTC_3033 9090887 49.47 µM 1.2140800308506 0.130868179400984 no 440 0.112358582348347 639 19325384 SGTC_80 0159-0065 512.242 µM 1.21386047158499 0.130911789640607 no 441 0.112400504810848 478 1548079 SGTC_2061 5245884 80.95 µM 1.21272266315138 0.131137949160419 no 442 0.112617936024847 626 573863 SGTC_1211 1056-0033 32.3 µM 1.21254756766027 0.131172776428586 no 443 0.112651422813566 629 6741922 SGTC_1346 1488-2224 62.4 µM 1.20789636037847 0.132100261569533 no 444 0.113543564873486 640 3722427 SGTC_2685 mycophenolic acid 18.85 µM 1.20762621775518 0.132154268606502 no 445 0.113595534937277 565 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_973 1325-0077 65.9 µM 1.20647751074067 0.132384088624495 no 446 0.11381671268001 671 2835149 SGTC_1604 st002052 72.4 µM 1.20160660139329 0.133361663207244 no 447 0.114757991312163 630 6254834 YHR062C RPP1 SGTC_332 4112-0506 40.9 µM 1.19860051984757 0.13396744547129 no 448 0.115341657983751 625 2790355 SGTC_3038 9091290 49.47 µM 1.19856737265141 0.133974135781171 no 449 0.115348105647535 620 25236843 SGTC_579 4491-1009 110 µM 1.19610791417465 0.134471184555773 no 450 0.115827224806804 791 1271041 SGTC_3287 9117173 37.0625 µM 1.19565181627398 0.134563499477317 no 451 0.115916230881767 564 2789709 SGTC_3180 9109287 49.47 µM 1.19539707862016 0.134615077701641 no 452 0.115965963266379 568 18891271 SGTC_1297 1068-0111 14.1 µM 1.19348358218968 0.135002948299881 no 453 0.116340019117146 594 767057 SGTC_3076 9116187 49.47 µM 1.19309868775336 0.13508105988629 no 454 0.116415362696337 569 27241210 SGTC_365 0121-0052 13.6 µM 1.18809746265668 0.136098840922983 no 455 0.117397506948956 695 3101739 SGTC_3086 9117350 49.47 µM 1.18775385059379 0.136168960351772 no 456 0.117465200511192 542 2679265 SGTC_2518 prenyletin 46.28 µM 1.18732166814949 0.136257189054842 no 457 0.117550382186221 529 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1988 st071872 53.4 µM 1.18715198333522 0.13629184037424 no 458 0.117583838432688 629 16414116 SGTC_2401 5128683 200 µM 1.18303919774847 0.137133556323796 no 459 0.118396806481756 580 708373 SGTC_135 0933-0004 26.348 µM 1.18255417626321 0.137233053615538 no 460 0.118492941213074 605 21230617 YGL099W LSG1 SGTC_2743 auranofin 4.32 µM 1.17859278101161 0.138047540008511 no 461 0.119280183792095 605 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1791 st048313 56.1 µM 1.17318132267894 0.139165486195774 no 462 0.120361550134473 595 1204976 SGTC_3183 9108214 49.47 µM 1.17263355829109 0.139278990575963 no 463 0.120471392992917 516 4974831 SGTC_1457 k015-0032 57.3 µM 1.17239017529521 0.139329443115535 no 464 0.120520221082143 642 4302660 SGTC_473 2-arachidonoylglycerol 10 µM 1.17154560567533 0.139504616208475 no 465 0.120689768778514 623 5282280 An endocannabinoid. SGTC_2710 st078562 53.7235 µM 1.17107462149186 0.139602368576171 no 466 0.120784391940921 635 17250908 SGTC_1425 4048-4433 7.33 µM 1.17024487740812 0.139774694545755 no 467 0.120951218828481 689 23734946 SGTC_1334 1486-0610 236 µM 1.16895772362202 0.140042304013453 no 468 0.121210332430532 672 3742339 SGTC_2221 6807166 181.081 µM 1.16199886996113 0.141495131527431 no 469 0.122617961976507 566 674925 SGTC_2024 5144227 134 µM 1.16155635580828 0.141587861087053 no 470 0.122707859492159 696 3475211 SGTC_1739 st037196 92.5 µM 1.15249629668102 0.143495463519752 no 471 0.124558595332692 712 612214 SGTC_3007 9078383 71.4286 µM 1.13853145053182 0.146469612368447 no 472 0.127449316959263 682 6496995 SGTC_121 0557-0495 61.343 µM 1.13734107819463 0.146725030992618 no 473 0.127697864326225 846 3104427 SGTC_1315 1237-0019 3.69 µM 1.13654095824066 0.146896880870348 no 474 0.127865117001415 693 825140 SGTC_459 nigericin 15.3 µM 1.13261511410292 0.147742029941914 no 475 0.12868795938283 698 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_287 k060-0039 29.6 µM 1.131678438926 0.147944155964864 no 476 0.128884824709622 669 5861974 SGTC_2384 9036245 200 µM 1.13167429664359 0.147945050242824 no 477 0.128885695775828 702 6462766 SGTC_33 0986-0033 35.816 µM 1.13073657531747 0.148147588170111 no 478 0.129082991041868 638 2848082 SGTC_2592 piperlongumine 83.33 µM 1.12758900462079 0.148828786347711 no 479 0.129746766219391 621 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3096 9117468 49.47 µM 1.12590876625803 0.149193279625927 no 480 0.130102069209249 561 41316311 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.12283428875524 0.149861766671789 no 481 0.130753939859417 507 6708630 An antioxidant. SGTC_466 geldanamycin 89.2 µM 1.12069748397332 0.15032754943317 no 482 0.131208326771213 555 5288382 HSP90 inhibitor. SGTC_861 0443-0273 110 µM 1.11729333421904 0.151071579848534 no 483 0.131934462323183 706 6149169 SGTC_2786 7743617 45.45 µM 1.11358399188684 0.151885100038035 no 484 0.132728848548001 601 583674 SGTC_1115 galangin 695.678 nM 1.11201641867974 0.152229768061889 no 485 0.133065545514718 747 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1169 aniline yellow 25.8 µM 1.1114598610323 0.152352265233569 no 486 0.133185229088949 657 6051 A DNA damaging agent. SGTC_251 melphalan 456.522 µM 1.10884895874772 0.152927792561508 no 487 0.13374767291787 784 460612 A DNA alkylator. SGTC_871 0574-0004 149 µM 1.1072860639121 0.153272993968019 no 488 0.134085133844153 749 9551173 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.10220043199705 0.154399844053826 no 489 0.135187272114026 719 2333 A French combination drug. SGTC_1413 3910-0535 34.4 µM 1.09859104318771 0.15520291005944 no 490 0.135973243135742 738 2876951 SGTC_2741 miltefosine 3.04 µM 1.09745938350002 0.155455263878353 no 491 0.136220313303808 610 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1846 st056244 14.8 µM 1.09741794682056 0.155464509162494 no 492 0.13622936581429 752 5393182 SGTC_563 tetrahydrosecaminediol 614 µM 1.09577921382755 0.155830431452913 no 493 0.136587703544894 744 334274 A psychoactive constituent of the cannabis plant. SGTC_317 4495-0002 170 µM 1.09563388783164 0.155862909535766 no 494 0.136619512711642 649 15991618 SGTC_2142 5622915 118.518 µM 1.09478519991675 0.15605266710815 no 495 0.136805375931782 676 5322196 SGTC_1521 st012942 49.4 µM 1.09319535297946 0.156408549517216 no 496 0.137154018469394 763 24207259 SGTC_2915 7971052 15.16 µM 1.09262079926946 0.156537293000537 no 497 0.137280163340979 536 5741558 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.09139835457247 0.15681144514824 no 498 0.137548818065565 728 688664 SGTC_2670 beta-carotene 100 µM 1.09040531197834 0.157034382764085 no 499 0.13776732147696 635 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.08999330474174 0.157126939364839 no 500 0.137858046673182 730 688667 SGTC_970 1315-0089 19.5 µM 1.08821212218623 0.15752749119423 no 501 0.138250737228588 679 6811083 YLR033W RSC58 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.08563697002055 0.15810777595396 no 502 0.138819818318658 692 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1007 4101-0031 70 µM 1.08294030466412 0.158716944551616 no 503 0.139417460269969 749 1146276 SGTC_1226 3909-7979 35.4 µM 1.08244058514022 0.158829998456539 no 504 0.139528401339775 771 6615510 SGTC_2971 9092186 9.93 µM 1.08008781704995 0.159362985372512 no 505 0.14005153824256 651 25236400 SGTC_2192 5915882 198.485 µM 1.07916137882136 0.159573178063485 no 506 0.140257896589998 670 2876149 SGTC_2740 felodipine 17.08 µM 1.07165015081347 0.161284040865476 no 507 0.141938599364251 669 3333 L-type calcium channel blocker SGTC_2576 guaiol 23.12 µM 1.07079382075258 0.161479847648318 no 508 0.142131072980689 781 227829 SGTC_2791 5663188 71.43 µM 1.07040445859786 0.161568929688847 no 509 0.142218646626721 697 54690634 SGTC_2894 9048625 32.47 µM 1.06952283584627 0.161770754246134 no 510 0.142417072305046 735 4092861 SGTC_3231 9132313 49.47 µM 1.06945214776044 0.161786943552971 no 511 0.14243299008564 725 4905967 SGTC_828 2074-0507 139 µM 1.06520002636438 0.162762725444158 no 512 0.143392710851241 752 X828 SGTC_3283 9109332 35.8195 µM 1.06373208651386 0.163100476981399 no 513 0.14372504227013 643 17027281 SGTC_268 camptothecin 39.6153 µM 1.06190950840092 0.163520459047001 no 514 0.144138384041475 830 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3174 9107204 49.47 µM 1.06141644538981 0.163634197604453 no 515 0.144250343217748 712 3938802 SGTC_1403 3909-7815 62.9 µM 1.06022928575191 0.163908259322117 no 516 0.144520150456156 700 6615483 SGTC_935 2996-0153 430 µM 1.05923315814914 0.164138450024445 no 517 0.144746803794218 754 23738523 SGTC_1181 1222-0449 220 µM 1.0567697535565 0.164708607212845 no 518 0.145308340761988 759 658318 SGTC_87 0100-0052 35.5 µM 1.05657131728841 0.164754591240569 no 519 0.145353638320625 955 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1227 3909-8010 46.6 µM 1.0565028201896 0.164770466139017 no 520 0.145369276535174 737 15982272 SGTC_2902 5787006 60.46 µM 1.05517219736859 0.165079048070008 no 521 0.145673288619249 734 591003 SGTC_708 3448-5400 146 µM 1.05491269453169 0.165139272394825 no 522 0.145732627919375 756 3462195 SGTC_2054 5233173 129 µM 1.05167539662059 0.165891766012632 no 523 0.146474251361634 786 6889 SGTC_727 3032-0951 202 µM 1.05163600353559 0.165900936364146 no 524 0.146483291386311 724 3652836 SGTC_1230 0170-0365 3.77 µM 1.05001448157859 0.166278696211819 no 525 0.14685572734492 886 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_735 3076-0345 636 µM 1.04582980579714 0.167256148871027 no 526 0.14781980865454 801 2888990 SGTC_2931 9014674 55.67 µM 1.04343867010336 0.167816327451392 no 527 0.148372585762614 728 2996810 SGTC_3237 9133362 49.47 µM 1.04330562623079 0.167847531476168 no 528 0.148403383083125 755 43845137 SGTC_538 2922-0838 53.3 µM 1.04156556340675 0.168255988572896 no 529 0.148806570694443 838 777039 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.04044574463857 0.168519189311854 no 530 0.149066429186722 807 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_439 amiodarone 34.4 µM 1.04040259174608 0.168529337205339 no 531 0.149076449052403 774 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2111 5486399 200 µM 1.03998201587411 0.16862826097839 no 532 0.149174128028627 820 689674 SGTC_777 1315-0167 517 µM 1.03815794618646 0.16905773281281 no 533 0.14959826380911 714 4221767 SGTC_2094 5332512 191.667 µM 1.0364289072723 0.169465477871317 no 534 0.1500010450717 793 755774 SGTC_253 dyclonine 31.25 µM 1.03438136158918 0.169949149199226 no 535 0.150478957117194 822 3180 An oral anasthetic. SGTC_2274 7947094 46.08 µM 1.03216696399444 0.170473229340156 no 536 0.150996954097182 781 2971028 SGTC_333 3486-0131 40.1 µM 1.02558582978004 0.172036883381824 no 537 0.152543424780203 808 6744690 SGTC_1641 st009299 47.1 µM 1.02476493724581 0.17223256475786 no 538 0.152737057155656 717 4046054 SGTC_1483 3453-0561 55.9 µM 1.02392505158099 0.172432920578041 no 539 0.152935338291917 806 4546991 SGTC_2702 st077768 96.8 µM 1.02350089408398 0.172534160374508 no 540 0.153035538692177 693 6484119 SGTC_2997 9067075 71.4286 µM 1.02312023210127 0.17262505073554 no 541 0.153125501020603 798 27209819 SGTC_2636 apigenin dimethyl ether 100 µM 1.02272355172453 0.172719798271527 no 542 0.153219286283218 767 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1218 1348-1416 30.7 µM 1.02260178596632 0.172748888802693 no 543 0.153248082418431 755 6787668 SGTC_2199 6590217 200 µM 1.02154794040712 0.173000788960568 no 544 0.153497454016562 706 703109 SGTC_2193 5925765 200 µM 1.021324674059 0.173054186225943 no 545 0.153550320039655 739 877370 SGTC_2988 9073640 71.4286 µM 1.02121485117619 0.173080455754094 no 546 0.153576328825932 735 9102229 SGTC_617 3770-0098 35 µM 1.02098152476079 0.173136275639306 no 547 0.153631595998609 736 5962639 SGTC_671 0560-0003 407 µM 1.01978224721227 0.173423365908075 no 548 0.15391587225076 759 3238678 SGTC_1278 0874-0585 172 µM 1.01885252877768 0.17364613588469 no 549 0.154136491702901 793 766306 SGTC_1621 st003705 32.4 µM 1.01881964898082 0.173654017549715 no 550 0.154144297809859 827 24207032 SGTC_1773 st048542 73.5835 µM 1.0161682701035 0.174290332638548 no 551 0.154774631668267 761 3237138 SGTC_2859 9028643 45.46 µM 1.01481951421162 0.174614593786598 no 552 0.155095934934458 754 17151580 SGTC_1646 st011709 75.6 µM 1.0145291983478 0.174684440144796 no 553 0.155165152104792 743 5757843 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.01364324489938 0.174897699083034 no 554 0.155376507370898 810 3256 An antibiotic and ribosome inhibitor. SGTC_1241 0364-0022 50.8 µM 1.01275363204939 0.17511200505384 no 555 0.155588926701987 793 4563895 SGTC_3230 9131665 49.47 µM 1.01253629286218 0.175164386940694 no 556 0.155640851462874 667 15943720 SGTC_3162 9099653 49.47 µM 1.01041237028858 0.175676806010435 no 557 0.156148881837317 748 25237511 SGTC_3071 9117417 49.47 µM 1.01027525671522 0.175709918732458 no 558 0.156181716138645 689 45595590 YGL055W OLE1 SGTC_1836 st055642 81 µM 1.00938979344115 0.175923851994293 no 559 0.156393865717104 784 8571 SGTC_151 3013-0144 2.285 µM 1.00584725351193 0.176781400114917 no 560 0.157244526273924 801 906558 YHR107C CDC12 SGTC_2434 5670830 169.91 µM 1.00477407046985 0.177041707832919 no 561 0.157502826098489 783 1549830 SGTC_58 0957-0393 9 µM 1.00337673955063 0.17738100251783 no 562 0.157839561333123 945 6997992 SGTC_497 capsazepine 133 µM 1.00294389900708 0.177486186471336 no 563 0.157943965078935 776 2733484 A calcium channel blocker. SGTC_625 k213-0058 121 µM 0.997946515253449 0.178703443528778 no 564 0.159152647294038 962 3655420 SGTC_730 1436-0052 41.2 µM 0.997330342876094 0.17885389326103 no 565 0.159302095069965 769 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3044 9093193 49.47 µM 0.997228901126774 0.178878669756519 no 566 0.159326707777598 802 25236277 SGTC_2669 eugenol 100 µM 0.997135016959314 0.178901602285928 no 567 0.159349489015506 750 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1559 coumarin 343 70.1 µM 0.996517058859607 0.179052593418216 no 568 0.159499491378475 768 108770 A hepatotoxic, DNA x-linker. SGTC_2539 epi(13)torulosol 80 µM 0.995916198880111 0.179199483673198 no 569 0.159645431966718 756 6708597 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.995853135776592 0.17921490489559 no 570 0.159660754188821 822 16623 A steroid. SGTC_1480 1070-0044 41.2 µM 0.994726583868281 0.179490528432354 no 571 0.159934630709912 817 3124987 SGTC_2699 st077704 54.6 µM 0.994259281616932 0.1796049373058 no 572 0.160048326871098 795 645852 SGTC_3030 9087619 49.47 µM 0.994233974070109 0.179611134620491 no 573 0.160054485787991 808 25236973 SGTC_394 menadione 8.33 µM 0.993701995689653 0.17974143664216 no 574 0.160183985432942 822 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2778 tioconazole 65.09 nM 0.9911503413981 0.180367260479161 no 575 0.160806087256177 788 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2064 5220758 200 µM 0.990884208283112 0.180432611460765 no 576 0.160871062118599 846 788518 SGTC_1496 4469-0713 57.4 µM 0.990053503444805 0.180636692792658 no 577 0.161073984131481 815 746691 SGTC_726 3448-4391 34.2 µM 0.988302390796303 0.181067366950741 no 578 0.161502287445643 852 1356692 SGTC_2980 9014342 25.29 µM 0.987287503780161 0.181317265673939 no 579 0.161750857473466 754 2996599 SGTC_1197 1601-0112 267 µM 0.984452208298215 0.182016552875986 no 580 0.16244660942688 832 7350313 SGTC_2196 6573537 42.6665 µM 0.984383550735862 0.182033507217962 no 581 0.162463481393593 825 2903087 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.984357241126341 0.182040004391293 no 582 0.162469947041224 974 688664 SGTC_593 1203-0218 61.7 µM 0.983912187274172 0.182149932668212 no 583 0.162579345433018 858 3666956 SGTC_449 xestospongin c 11.1929 µM 0.981807871751896 0.182670260227994 no 584 0.163097254700383 843 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2452 5863136 48.41 µM 0.979955234153215 0.183129123578385 no 585 0.163554108205887 806 2184096 SGTC_2640 pentamidine 10.38 µM 0.978746333625181 0.183428932727612 no 586 0.163852666157382 890 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_742 0kpi-0133 140 µM 0.978383723227198 0.183518920272554 no 587 0.163942287696517 859 2728852 SGTC_1979 st071809 45.3 µM 0.976679747116362 0.183942157435424 no 588 0.164363862403547 847 4976333 SGTC_2690 usnic acid 100 µM 0.975253741166727 0.184296818567591 no 589 0.164717205204474 885 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2629 bisabolol 100 µM 0.973685550907259 0.184687333181027 no 590 0.165106346867101 846 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_272 doxorubicin 8.13 µM 0.973056699166834 0.184844075805391 no 591 0.165262561562638 866 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1555 citronellol 128 µM 0.972317630665416 0.185028395840381 no 592 0.165446277715051 796 8842 A terpine precursor. SGTC_2405 ticlatone 3.52 µM 0.971303249198066 0.185281563413866 no 593 0.165698645632536 824 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_344 k064-0035 6.43 µM 0.968577627093659 0.185962884243039 no 594 0.166377985265229 804 5088750 SGTC_1415 3966-0071 78.1 µM 0.968170812209455 0.186064708390617 no 595 0.166479534667681 840 2893185 SGTC_1990 st072050 59.8 µM 0.96727229381875 0.186289726409213 no 596 0.166703965179891 842 17233948 SGTC_217 ketoconazole 989 nM 0.966679672647707 0.186438230123975 no 597 0.166852095962518 829 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1920 st075728 45.7 µM 0.963115905814305 0.187332812626723 no 598 0.167744680226113 833 3400306 SGTC_1449 4112-4002 201 µM 0.962962465535139 0.187371388947235 no 599 0.16778317993426 782 2059539 SGTC_3119 9125183 49.47 µM 0.962479801490762 0.187492767214977 no 600 0.167904322287478 688 22695334 SGTC_452 diindolylmethane 8 µM 0.96175891592151 0.187674142864621 no 601 0.168085359942516 779 3071 Inhibits expression of several cancer promoting factors. SGTC_942 3253-1115 227 µM 0.960026662543876 0.188110422805337 no 602 0.16852089807442 843 46497897 SGTC_3114 9122766 49.47 µM 0.955610695453655 0.189225443239987 no 603 0.169634477957114 772 17176985 SGTC_1730 st033808 45.1 µM 0.954852320953508 0.189417339488602 no 604 0.169826192052311 927 1045166 SGTC_2929 9013348 24.6 µM 0.953886922066384 0.189661793618022 no 605 0.170070442017052 805 2995952 SGTC_1932 st074806 40.9 µM 0.953606651265901 0.189732798908884 no 606 0.170141393853029 896 17251235 SGTC_2502 avocadyne acetate 18.59 µM 0.9532371858105 0.189826426224483 no 607 0.170234954703782 935 3952079 SGTC_3334 9142812 21.919 µM 0.953230768837178 0.189828052619315 no 608 0.170236579984451 821 45283678 SGTC_1033 k072-0102 21.3 µM 0.952305108501102 0.190062752857858 no 609 0.170471133893473 871 5965931 SGTC_3195 9113082 49.47 µM 0.952054918917453 0.190126218775178 no 610 0.170534565168855 828 17018038 SGTC_956 1185-0240 191 µM 0.951483947310055 0.190271106651726 no 611 0.17067938181352 834 1416193 SGTC_493 zm226600 134 µM 0.951388288748413 0.190295387285659 no 612 0.17070365157824 856 5240098 A potassium channel opener. YCR052W RSC6 SGTC_588 3970-1144 52.9 µM 0.947857426252194 0.191192943382867 no 613 0.171601020519565 848 1888707 SGTC_3106 9121286 49.47 µM 0.947207012672849 0.191358563152651 no 614 0.171766651325032 809 15943471 SGTC_953 1188-0045 9.7 µM 0.943306161050696 0.192353710608612 no 615 0.172762162714817 878 6144426 SGTC_1280 0880-0253 10.1 µM 0.942711509549296 0.192505689849465 no 616 0.17291424232812 860 6836607 SGTC_2237 6667747 47.222 µM 0.941942161484983 0.192702426400295 no 617 0.173111126386248 820 729940 YDL015C TSC13 SGTC_2850 9015429 58.44 µM 0.941816082414586 0.192734678866767 no 618 0.173143404925162 811 6457570 SGTC_2175 5807670 165.306 µM 0.94059446858124 0.193047352417805 no 619 0.173456358811654 854 241186 SGTC_1834 st055981 52.8 µM 0.940185953102282 0.193151981519639 no 620 0.173561092873963 883 471719 YDL150W RPC53 SGTC_1956 st077085 54 µM 0.938891139723272 0.193483838174899 no 621 0.173893319376675 887 24208685 SGTC_1131 3454-3128 32.3 µM 0.936703122848757 0.194045409984016 no 622 0.174455644722099 911 710982 SGTC_362 0310-0100 9.03 µM 0.9365138642224 0.194094031323766 no 623 0.174504338838254 834 790235 SGTC_941 3237-0776 460 µM 0.936357263186597 0.194134268401419 no 624 0.174544637049501 851 760008 SGTC_1948 st076329 66.6 µM 0.936038831188519 0.194216102003182 no 625 0.174626597516389 823 24208413 SGTC_3075 9116269 49.47 µM 0.935273961150145 0.194412751203421 no 626 0.174823565452145 863 17015205 YNL244C SUI1 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.932632045651252 0.195092923406203 no 627 0.175504990881749 820 5282362 SGTC_206 4546-0025 72.014 µM 0.929935996206308 0.195788521813292 no 628 0.176202112075493 917 6620745 YIL048W NEO1 SGTC_2544 sphondin 68.51 µM 0.92908771341427 0.196007695259598 no 629 0.176421815678731 852 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1348 1493-0373 93.8 µM 0.92906348039938 0.196013958604398 no 630 0.176428094527769 862 3010129 SGTC_2809 7964133 12.99 µM 0.92512711408344 0.197032975792916 no 631 0.177449895341147 866 1253665 SGTC_376 3970-0862 59.1 µM 0.924969210962474 0.197073919353727 no 632 0.177490961570015 901 3135186 SGTC_366 0181-0206 4.31 µM 0.920940959534228 0.198120166981779 no 633 0.178540626201916 921 274874 SGTC_1749 st037932 54.2 µM 0.919471710224003 0.198502604556557 no 634 0.178924448039254 829 594497 SGTC_1068 loratadine 26.9 µM 0.917851974928188 0.198924728514119 no 635 0.179348183639528 859 3957 A H1 histamine antagonist. SGTC_2013 4024628 200 µM 0.916277603843304 0.199335548036575 no 636 0.179760655792991 826 5230760 SGTC_694 1315-0438 43.2 µM 0.915985845754479 0.199411736042868 no 637 0.179837159392612 823 6793154 SGTC_2966 9084041 48.03 µM 0.915810150074602 0.199457624644532 no 638 0.179883239451859 809 17741380 SGTC_2311 7694451 200 µM 0.915778212807698 0.199465966776062 no 639 0.179891616499522 869 2163142 SGTC_1703 st026983 48.3 µM 0.913666015356249 0.200018146670116 no 640 0.1804461833138 933 1104023 SGTC_1487 3970-0795 2.82 µM 0.913442654850115 0.200076592232505 no 641 0.180504890244543 923 3765103 SGTC_2965 9082772 38.63 µM 0.909711527603298 0.201054413888768 no 642 0.181487331597239 934 16459634 SGTC_2517 totarol 10 µM 0.909632118623095 0.201075255813228 no 643 0.181508277048862 832 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2460 5552655 174.22 µM 0.909313064339128 0.201159008841043 no 644 0.181592448224136 858 5401989 SGTC_3281 9140613 49.47 µM 0.909279395206323 0.201167848343421 no 645 0.181601332057306 823 16013766 SGTC_1927 st060202 13.8 µM 0.908212756586816 0.201448004467092 no 646 0.181882912803448 894 688887 SGTC_1393 3470-5649 58.2 µM 0.907722065724001 0.201576964511647 no 647 0.182012541395514 807 4108395 SGTC_1362 1611-0397 101 µM 0.907676633719747 0.201588907144023 no 648 0.182024546347237 889 27816 SGTC_3232 9132874 49.47 µM 0.906402376842096 0.201924041490363 no 649 0.182361457606265 885 3784940 SGTC_769 0302-0231 76 µM 0.905589128453282 0.202138103121622 no 650 0.182576682585084 970 571869 YER009W NTF2 SGTC_607 4491-0986 66.8 µM 0.905575015334266 0.202141819147093 no 651 0.1825804190009 939 698981 YDR232W HEM1 SGTC_2231 micatex 6.853 µM 0.904355251430838 0.202463140952636 no 652 0.182903529092647 917 20737 An antifungal of unknown mechanism. SGTC_1296 1068-0102 11.9 µM 0.90281254164641 0.202869973312734 no 653 0.183312696863228 903 767053 SGTC_2908 7930301 100 µM 0.902387648448745 0.20298210881049 no 654 0.183425490038841 954 2223178 SGTC_2507 purpurin 79.67 µM 0.90122369497577 0.203289482600065 no 655 0.183734697478466 923 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3129 9127257 49.47 µM 0.899351608667343 0.203784440520952 no 656 0.184232703053604 769 837894 SGTC_1318 1280-3875 124 µM 0.899140151730097 0.203840392401741 no 657 0.18428900681041 903 373245 SGTC_132 0417-1715 25.805 µM 0.89900320920181 0.203876632522239 no 658 0.184325475638092 937 6769098 SGTC_182 3448-4371 550.524 µM 0.898805794924918 0.20392888248887 no 659 0.184378056450162 980 3491403 SGTC_3087 9117406 49.47 µM 0.897184271413244 0.204358355696647 no 660 0.184810298326885 863 42546093 SGTC_2290 7904846 200 µM 0.896967621508861 0.204415777870521 no 661 0.184868097331042 902 2962154 SGTC_831 k061-1017 217 µM 0.895435960158901 0.204822012358706 no 662 0.185277042422997 1038 1240153 SGTC_1524 corynanthine 62.1 µM 0.89523004564049 0.204876662570931 no 663 0.185332063261586 884 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1885 st057546 99.9 µM 0.894485757221285 0.205074270818629 no 664 0.185531023450749 958 702008 SGTC_1191 1487-1166 10.6 µM 0.894304488090581 0.205122414841813 no 665 0.185579499652195 1013 3955771 SGTC_1253 0550-0034 176 µM 0.894089260726632 0.205179586694879 no 666 0.185637067396573 855 5969915 SGTC_1877 wortmannin 25 µM 0.893299873578995 0.205389356336229 no 667 0.185848302839324 955 312145 A covalent inhibitor of PI 3-kinase. SGTC_1652 st011932 78 µM 0.892502215542769 0.205601453189614 no 668 0.186061902881236 904 1551076 SGTC_74 000s-0487 160.283 µM 0.8919918004864 0.205737240476888 no 669 0.186198663670194 980 677548 SGTC_2319 6033012 152.6 µM 0.891710401355607 0.205812124705986 no 670 0.186274088484934 839 847246 SGTC_2770 toltrazuril 17.5 µM 0.8917040853686 0.205813805663667 no 671 0.186275781607679 953 68591 Kills coccidiodes. SGTC_2898 9056270 58.44 µM 0.890890800229416 0.206030324112568 no 672 0.186493878116998 874 19154699 SGTC_2336 9001819 198.65 µM 0.889994217833064 0.206269175015117 no 673 0.186734495422323 944 2989602 SGTC_2167 5876490 200 µM 0.889473916932387 0.206407859184988 no 674 0.186874217516538 941 686534 SGTC_2204 7233102 200 µM 0.889085706614627 0.20651137110776 no 675 0.186978510013518 870 2172480 SGTC_1167 k781-0610 148 µM 0.88854686795202 0.206655097339381 no 676 0.187123328402386 949 4525169 SGTC_446 go6976 132 µM 0.888049090840977 0.206787923709251 no 677 0.187257172707618 901 3501 A protein kinase C inhibitor. SGTC_2505 galangin 7.89 µM 0.886925117083852 0.207088029636614 no 678 0.187559608941508 854 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2068 5226020 147 µM 0.886341834010259 0.207243870276162 no 679 0.187716676279652 991 1810509 SGTC_2829 7992743 58.44 µM 0.885215880983325 0.207544896692518 no 680 0.188020104311279 950 16462845 SGTC_628 1636-0253 16 µM 0.883987040750424 0.207873724985432 no 681 0.188351604269734 931 4456143 SGTC_3234 9132280 49.47 µM 0.882214574563119 0.208348564969853 no 682 0.188830390924809 918 17612295 SGTC_297 0986-0032 24 µM 0.880633281408769 0.208772729627847 no 683 0.189258169458293 912 2847425 SGTC_3265 9137266 49.47 µM 0.880045913659534 0.20893041414973 no 684 0.189417218671771 917 17224265 SGTC_1350 1495-0454 146 µM 0.875744438313398 0.210087323056451 no 685 0.190584490654499 977 1069057 SGTC_2045 5106652 78.05 µM 0.874504554203023 0.210421495157189 no 686 0.190921770573135 953 673349 SGTC_443 clozapine 122 µM 0.873300772774348 0.210746235245875 no 687 0.191249579727187 866 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_86 0417-1630 471.922 µM 0.87252791503651 0.210954881358968 no 688 0.191460223142198 1044 3634867 SGTC_1575 cyproterone acetate 48 µM 0.872379428594745 0.210994981668401 no 689 0.191500709594807 910 9880 An androgen receptor antagonist and liver toxin. SGTC_1805 st050013 60.3 µM 0.870800414380231 0.211421687245387 no 690 0.191931569487652 918 4037144 SGTC_832 4083-0019 164 µM 0.870206784106624 0.211582237797671 no 691 0.192093704580737 1098 1990758 SGTC_2912 7964298 10.93 µM 0.869945342178019 0.211652968829534 no 692 0.19216513740425 958 2975850 SGTC_2229 7354935 190 µM 0.86641352015954 0.212609830695679 no 693 0.193131716126088 913 318112 SGTC_2179 6298986 200 µM 0.866334773682289 0.212631193903824 no 694 0.193153301003052 912 738374 SGTC_489 paxilline 115 µM 0.861436016712957 0.213962645266218 no 695 0.194498973274569 925 105008 A toxic potassium channel blocker. SGTC_1344 1488-0097 29.1 µM 0.860482849393829 0.214222273057929 no 696 0.194761466780791 933 747966 SGTC_2160 5660466 132.927 µM 0.858468731445714 0.214771489558244 no 697 0.195316844657577 916 2859134 SGTC_1031 k035-0009 16 µM 0.85782710523743 0.214946622039088 no 698 0.195493970143508 1029 5180959 SGTC_2870 9038528 12.99 µM 0.856117694203288 0.215413612032125 no 699 0.195966341171577 864 6463316 SGTC_1614 st002383 48.6 µM 0.855453250610443 0.21559528855443 no 700 0.196150137284707 960 1947235 SGTC_2307 7538926 6.34 µM 0.854260913419656 0.21592152788744 no 701 0.196480219520012 963 96582 SGTC_199 4063-0024 41.6 µM 0.853626886430724 0.216095122543029 no 702 0.196655878217408 997 306215 SGTC_2348 9022543 33.42 µM 0.851870486660532 0.216576441359249 no 703 0.197142989536555 969 3162678 YDL140C RPO21 SGTC_2960 9079389 5.97 µM 0.850977251564833 0.216821458691856 no 704 0.197390994799252 976 16457355 SGTC_1017 4239-0030 168 µM 0.847823482819032 0.217687828673332 no 705 0.198268141543286 942 1149593 SGTC_1952 st077036 64.1 µM 0.84780780384216 0.217692140819649 no 706 0.198272508151462 1029 2937007 SGTC_2756 carbadox 75.1 µM 0.847535801505109 0.217766956725098 no 707 0.198348270267687 934 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2038 4100038 30.985 µM 0.846097464511639 0.218162826621072 no 708 0.198749187537766 940 3596803 SGTC_890 0929-0006 47.2 µM 0.844893235596238 0.218494582274137 no 709 0.199085225787827 943 1378169 SGTC_2411 st077133 39.94 µM 0.843854188085532 0.218781065068302 no 710 0.199375445332934 1015 1403142 YNL221C POP1 SGTC_1105 epirubicin 18.1 µM 0.843686648623048 0.218827278731156 no 711 0.199422265129987 948 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_749 1000-0129 128 µM 0.8436756699285 0.218830307262654 no 712 0.199425333415845 1034 708470 SGTC_2697 mebhydrolin 72.4 µM 0.843133766080578 0.21897982430291 no 713 0.199576818063988 992 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3269 9137823 49.47 µM 0.841815963973859 0.219343665013826 no 714 0.199945487370473 905 17682936 SGTC_2458 5808907 16.39 µM 0.841645928438781 0.219390636542012 no 715 0.199993086449773 1055 2731747 SGTC_1617 st002906 78 µM 0.841357395368799 0.219470355688421 no 716 0.200073872850942 986 5150859 SGTC_2737 bleomycin 30.5 nM 0.840990376042482 0.219571783939328 no 717 0.200176662968848 1038 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1554 st069299 38.7 µM 0.840816761092777 0.219619772972722 no 718 0.200225297897774 1007 24207999 SGTC_770 0389-1121 67.2 µM 0.839709916537029 0.219925858244235 no 719 0.200535526271589 1036 6753108 SGTC_60 0986-0278 202 µM 0.837704168317191 0.220481148382341 no 720 0.201098435908637 887 3110598 SGTC_2235 salicylic acid 500 µM 0.835319174885816 0.221142476850071 no 721 0.201769011983677 1006 338 A COX inhibitor and kinase inhibitor. SGTC_1886 st057356 49.9 µM 0.834303448053464 0.221424469270619 no 722 0.202055004663961 934 24207747 SGTC_1311 1190-0148 100 µM 0.832993333120997 0.221788494981952 no 723 0.20242424463935 1095 1961333 SGTC_211 3455-0679 143.504 µM 0.831635275317467 0.222166202601957 no 724 0.202807422306717 1015 748649 SGTC_2948 9070189 9.45 µM 0.831106472496626 0.222313374270432 no 725 0.20295674180905 905 6473636 YDL196W YDL196W SGTC_1868 st057644 42.7 µM 0.830084940929792 0.222597835239297 no 726 0.203245380342371 1047 688665 SGTC_1497 4476-2978 41.3 µM 0.829123664474746 0.22286570666518 no 727 0.203517217131765 1035 1528379 SGTC_118 0083-0097 135.343 µM 0.828598792121315 0.223012046239161 no 728 0.203665735863812 1136 5207356 SGTC_2752 diclazuril 33.15 µM 0.828090784591903 0.223153735836314 no 729 0.203809544023699 1124 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1746 st038117 42 µM 0.825788714396595 0.223796453730752 no 730 0.204461978558485 969 2898218 SGTC_602 3130-1533 38.1 µM 0.825360388017234 0.223916154711223 no 731 0.204583508451812 1026 720941 SGTC_1977 st070720 65.3 µM 0.82467773905114 0.224107004387869 no 732 0.204777286612194 940 682188 SGTC_2851 9015922 71.43 µM 0.823454315196985 0.224449270752351 no 733 0.205124843265606 987 2996893 SGTC_922 1866-0035 480 µM 0.82282662296573 0.224624989680596 no 734 0.205303297345799 1071 3156169 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.822650102984272 0.224674419516625 no 735 0.20535349891769 976 803109 SGTC_592 k241-0073 46.5 µM 0.820037335091716 0.225406778399989 no 736 0.206097411890126 1051 4230158 SGTC_490 phenamil 164 µM 0.818274101927519 0.225901775528956 no 737 0.206600345315628 945 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2345 9052315 157.45 µM 0.816342413096025 0.226444768522127 no 738 0.207152161484152 992 6469265 SGTC_14 0354-0009 295 µM 0.815938923499562 0.226558281438373 no 739 0.207267534370573 1024 1713507 SGTC_312 4092-0653 6.84 µM 0.813196487802786 0.227330655949295 no 740 0.208052706394664 1071 1148278 SGTC_148 3253-0744 288.01 µM 0.811287903020233 0.227869060604608 no 741 0.208600177682499 1052 6893655 SGTC_3042 9091578 49.47 µM 0.811073381348662 0.22792962119072 no 742 0.208661765569724 991 25236497 SGTC_1116 jasmonic acid  1.58368 µM 0.809213658132831 0.228455010094407 no 743 0.209196130022992 1025 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_122 0236-0016 402.397 µM 0.80910979292628 0.228484373018034 no 744 0.209225997915828 1132 6808838 SGTC_2194 5927483 104.545 µM 0.808428896966636 0.228676916311293 no 745 0.209421861232507 1070 760979 SGTC_1370 2001-0092 44.6 µM 0.808253305266659 0.228726584785478 no 746 0.209472388604642 1106 790957 SGTC_559 1550-0661 158 µM 0.80810644096548 0.228768131979686 no 747 0.209514655034561 1021 5830875 SGTC_2089 5281248 129.67 µM 0.807664451260889 0.228893194268919 no 748 0.209641886578356 994 2737878 SGTC_1306 1185-0270 9.02 µM 0.807533389986706 0.228930285816955 no 749 0.209679622724318 1058 1548076 SGTC_731 3966-0296 387 µM 0.806952248727928 0.229094794777054 no 750 0.209846997394741 1039 660956 SGTC_616 4092-0450 108 µM 0.806086863076795 0.229339890239431 no 751 0.210096382873263 1048 787165 SGTC_1884 5633444 25 µM 0.805938601244169 0.229381895860466 no 752 0.210139126198754 1024 5724239 SGTC_1482 3346-2049 8.48 µM 0.805758519928847 0.229432922393821 no 753 0.210191049830337 1027 3826804 SGTC_1648 st011736 69.8 µM 0.805671284422574 0.229457643100292 no 754 0.210216205533706 1019 2855514 SGTC_938 3126-1755 342 µM 0.804672484789664 0.229740788256799 no 755 0.210504350803269 1069 1777771 SGTC_997 3996-0078 137 µM 0.802746791282445 0.230287246223265 no 756 0.211060550983749 1071 735687 SGTC_2880 9042983 58.44 µM 0.801402077189372 0.230669269095433 no 757 0.211449456505766 1023 6464714 SGTC_1729 st035615 45.989 µM 0.800997415890891 0.230784299507184 no 758 0.211566570920959 975 17385451 SGTC_1313 1220-0047 237 µM 0.800929252437541 0.230803679037218 no 759 0.21158630207642 1063 3528706 SGTC_1001 4048-4355 44.4 µM 0.80081969645584 0.230834828768238 no 760 0.21161801731164 1004 21824233 SGTC_1615 st002656 86.5 µM 0.800322396375353 0.230976254153783 no 761 0.211762015121547 1032 1584458 SGTC_2663 amphotericin b 100 µM 0.798925315993366 0.231373823540514 no 762 0.212166859271609 1043 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_142 0335-0849 62.6745 µM 0.79891066689172 0.231377994279481 no 763 0.212171106665109 1069 3889043 YPR107C YTH1 SGTC_2730 imipramine 71.33 µM 0.797561819843478 0.23176220351587 no 764 0.212562407380467 1111 3696 A tricyclic antidepressant. SGTC_857 0438-0306 1.35 µM 0.79569277087276 0.232295175482611 no 765 0.213105314849476 1047 4686136 SGTC_2129 girgensonine 121.053 µM 0.794119338522513 0.232744378523919 no 766 0.213562980242108 1084 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2181 6316240 54.2555 µM 0.791893241809094 0.233380736114977 no 767 0.214211463949628 1016 12779990 SGTC_2877 9040724 71.43 µM 0.791885528467352 0.233382942747109 no 768 0.214213712911211 1053 6463895 SGTC_2110 5483698 200 µM 0.790577840367625 0.233757213336283 no 769 0.214595191108319 1049 2848765 YHR062C RPP1 SGTC_3344 9148862 3.898 µM 0.788590334930068 0.234326689497325 no 770 0.215175740842086 1073 4905352 SGTC_2541 muurolladie-3-one 83.07 µM 0.788061501541873 0.234478344357119 no 771 0.215330366333963 1003 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2807 7945238 51.95 µM 0.786773420081815 0.234847957770027 no 772 0.21570725787699 1049 17148797 SGTC_3291 9121177 71.43 µM 0.785459864640003 0.235225212319217 no 773 0.216091996641057 967 17015612 SGTC_2361 9034121 116 µM 0.783089141363613 0.235906932784464 no 774 0.216787383620882 1043 6496917 SGTC_1941 st076221 61.8 µM 0.782236056014122 0.236152510488652 no 775 0.217037929156736 1089 2828568 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.782048719691266 0.236206457852356 no 776 0.217092970997005 1078 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2814 7977482 42.97 µM 0.781809090599421 0.236275473891835 no 777 0.21716338888606 1102 6456762 SGTC_1759 st043059 70 µM 0.781641861458581 0.236323644458929 no 778 0.217212538995792 1088 669426 SGTC_1382 3002-2117 298 µM 0.781565497547098 0.236345642979148 no 779 0.217234985155339 1112 1497314 SGTC_1557 sumaresinolic acid 42.3 µM 0.781165288467053 0.236460951573858 no 780 0.217352643217109 1022 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2519 cryptotanshinone 88.04 µM 0.780334807825385 0.236700329153923 no 781 0.217596914825725 1065 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1657 st012939 43.4 µM 0.779533299019529 0.236931482240425 no 782 0.217832815029723 1044 24207257 SGTC_356 1634-0012 32.5 µM 0.779031486869849 0.237076266721434 no 783 0.217980583518578 1084 735457 SGTC_1190 1486-1332 13 µM 0.77853008451634 0.237220981511541 no 784 0.218128289042165 1062 4150046 SGTC_2567 aureobasidin a 60 nM 0.778328451247985 0.23727919059969 no 785 0.218187703402151 1050 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1620 st003704 16.5 µM 0.776827420563566 0.237712766491918 no 786 0.218630298335709 1069 2834414 SGTC_440 fluspirilene 35.1 µM 0.776373507568669 0.237843965758955 no 787 0.218764241138163 1070 3396 An atypical antipsychotic. SGTC_2628 lathosterol 100 µM 0.775230883168924 0.238174406285789 no 788 0.219101621148649 1127 6710616 SGTC_578 3460-0051 92 µM 0.774832405761949 0.238289702832715 no 789 0.219219348955778 1156 2876744 SGTC_1255 0566-0045 221 µM 0.774357441006871 0.238427170367152 no 790 0.219359721991069 1068 2788469 SGTC_2358 9037157 4 µM 0.773778033936004 0.238594925087454 no 791 0.21953103225461 1065 2388925 SGTC_862 0452-0056 10.2 µM 0.773071316318666 0.238799627228706 no 792 0.219740087755413 1049 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1734 st037168 69.4 µM 0.772603659602965 0.238935137713889 no 793 0.21987848900681 1004 708907 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.772263893460435 0.239033616371037 no 794 0.219979072892232 1070 6708760 SGTC_1600 coumarin 106 71.1 µM 0.769692512514889 0.239779630695199 no 795 0.220741156313778 1084 100336 A hepatotoxic, DNA x-linker. SGTC_2148 5546263 113.568 µM 0.769449052717792 0.239850329522821 no 796 0.220813389074718 1066 792097 SGTC_31 0508-1974 57.237 µM 0.768052044232133 0.240256229643292 no 797 0.221228132950985 1057 6810525 SGTC_2105 5350118 200 µM 0.76764215166552 0.240375394708156 no 798 0.221349906355016 1104 2133313 SGTC_3061 glucosamine 200 µM 0.76749241585979 0.240418934330351 no 799 0.221394400345952 1057 91431 and experimental redox chemotherapeutic SGTC_1030 k029-0042 36.7 µM 0.764893836370552 0.241175223330249 no 800 0.222167382237233 1096 6080581 SGTC_3278 9139605 49.47 µM 0.763273944115027 0.241647329337085 no 801 0.222650018959431 1101 7958859 SGTC_2825 7998094 58.44 µM 0.762957194558545 0.241739702336946 no 802 0.222744462310763 1040 2987815 SGTC_1828 st055811 49 µM 0.758811251698745 0.242950540121495 no 803 0.223982736957331 1059 5877589 SGTC_3039 9090270 49.47 µM 0.757414627440098 0.243359166917052 no 804 0.224400747718958 1112 17173750 SGTC_1435 4092-0789 56.7 µM 0.756786136514999 0.243543173003751 no 805 0.224588999919206 1095 2248285 SGTC_1212 0520-0165 585 µM 0.756683746823051 0.2435731572066 no 806 0.224619677239337 1103 5403258 SGTC_1122 capsaicin 818.572 nM 0.756574028380515 0.243605289802558 no 807 0.224652552989237 1102 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1320 1313-0481 95.3 µM 0.754277432468643 0.244278405509359 no 808 0.225341325210147 1144 6813365 YLR208W SEC13 SGTC_102 gallobenzophenone 83.616 µM 0.754076660377358 0.244337297979631 no 809 0.225401595564562 1091 70837 SGTC_2748 diazoxide 86.69 µM 0.754052404220711 0.244344413555248 no 810 0.225408877708201 1031 3019 A potassium channel activatior. SGTC_1214 0358-0031 63.7 µM 0.751981990480862 0.244952183562891 no 811 0.226030944631278 1086 4301366 SGTC_2423 st077119 87.2 µM 0.751722532705577 0.245028404712206 no 812 0.226108968479597 1108 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_979 1426-2828 121 µM 0.745715285820561 0.246796721269118 no 813 0.227919711660346 1152 747872 SGTC_491 tetrandrine 80.3 µM 0.745399831628373 0.246889768021433 no 814 0.228015022820428 1091 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_178 4092-0806 87.505 µM 0.745185942653088 0.246952867653337 no 815 0.228079659871698 1088 2169044 SGTC_390 dec-rvkr-cmk 16.7 µM 0.740168106353921 0.248435658170014 no 816 0.229598998670859 1148 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2914 7968218 45.32 µM 0.737824257478452 0.249129897142475 no 817 0.2303106252883 1065 2977111 SGTC_1061 3448-9325 110 µM 0.735300890808415 0.249878460541487 no 818 0.231078132903626 1115 723482 SGTC_2642 cholecalciferol 100 µM 0.734289999250321 0.250178678805832 no 819 0.23138600586211 1119 9821465 A vitamin D precursor, similar to steriods. SGTC_2102 5377816 72.7585 µM 0.734013466924155 0.250260837696204 no 820 0.231470265234485 1167 1379702 SGTC_1872 amphotericin b 148 nM 0.732997069230432 0.250562936514097 no 821 0.231780108458367 1155 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2605 digitonin 300 nM 0.732557273120846 0.250693714779893 no 822 0.23191424946084 1201 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_90 0870-0863 4.608 µM 0.731397015151927 0.25103890380554 no 823 0.232268343957547 1142 1738164 SGTC_3282 9108498 15.4605 µM 0.730802193202054 0.251215967091624 no 824 0.232449991869039 1116 16459645 SGTC_657 3534-0529 86.7 µM 0.729270624127875 0.251672179826582 no 825 0.232918068895916 1152 1049549 SGTC_558 k064-0027 21.3 µM 0.72863566464642 0.251861445199496 no 826 0.233112278168767 1138 5088526 SGTC_140 0062-0056 502.533 µM 0.727233047723725 0.252279796003736 no 827 0.233541602313636 1157 3758964 SGTC_1486 3970-0793 4.53 µM 0.723462000659894 0.253406379571509 no 828 0.23469804583914 1170 2844330 SGTC_1649 st011737 51.3 µM 0.721261179395184 0.254065084930754 no 829 0.235374418439893 1118 1761035 SGTC_2797 7859098 81.82 µM 0.720033025849942 0.254433061142254 no 830 0.235752330850598 1192 972681 SGTC_2474 5321570 43.32 µM 0.72003297805175 0.254433075468859 no 831 0.235752345564983 1158 2841384 SGTC_1830 st055982 50.3 µM 0.719982465020509 0.254448216031577 no 832 0.235767895978866 1110 455313 An antimicrobial agent. SGTC_2369 9071472 200 µM 0.719331608789689 0.254643343155571 no 833 0.235968312359814 1161 17296037 SGTC_1179 1021-1431 9.29 µM 0.71858387875763 0.254867609804292 no 834 0.236198674669728 1154 2840958 SGTC_2218 6965428 192.983 µM 0.718525604836776 0.254885092241091 no 835 0.236216633028473 1154 675684 SGTC_945 3381-0768 11.3 µM 0.718241601929538 0.254970303365148 no 836 0.236304165378465 1181 1126236 YIL048W NEO1 SGTC_739 1486-1183 203 µM 0.717633731979175 0.255152736374987 no 837 0.236491576586139 1162 4346692 SGTC_1661 st013063 9.66 µM 0.717626285752092 0.255154971548547 no 838 0.236493872825041 1192 721395 SGTC_2453 5731132 22.18 µM 0.715025606800061 0.255936257069492 no 839 0.237296610295238 1200 1362040 SGTC_846 0335-0850 148 µM 0.714720914090917 0.256027873251587 no 840 0.237390755971807 1152 6819598 SGTC_1309 pyrazolanthrone 13.4 µM 0.710485493582632 0.257303165447267 no 841 0.238701561758674 1194 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3157 9099274 49.47 µM 0.708019058966609 0.258047331268948 no 842 0.239466710965678 1164 17217662 SGTC_2906 7926292 26.41 µM 0.706922588536993 0.258378513339485 no 843 0.239807292842778 1168 2966319 SGTC_3105 9121040 49.47 µM 0.705393316605104 0.258840787916385 no 844 0.240282751023719 1033 41448907 SGTC_3214 9129694 49.47 µM 0.704309713887861 0.259168602640194 no 845 0.240619959118165 1148 17158655 SGTC_1623 st003709 20.3 µM 0.704124184099919 0.259224751175476 no 846 0.240677720254137 1180 16192618 SGTC_1855 st056195 39.6 µM 0.702877350755382 0.259602254515383 no 847 0.241066093581452 1151 4028379 SGTC_1491 4138-0063 26.5 µM 0.702710688965354 0.2596527361495 no 848 0.241118032495517 1159 23883227 SGTC_1452 4194-0072 190 µM 0.702619919000413 0.259680232382271 no 849 0.241146322842493 1216 1343545 SGTC_2496 diffractaic acid 79.83 µM 0.702244857701509 0.259793862689824 no 850 0.241263237624451 1216 94870 An apoptosis inducer which activates caspases. SGTC_381 3461-2219 42.7 µM 0.700820270492976 0.260225695902975 no 851 0.241707593084185 1174 2883159 SGTC_2551 apiole 73.87 µM 0.699755139590334 0.260548809119583 no 852 0.242040117401319 1077 10659 A possible DNA adduct former. SGTC_3116 9124943 49.47 µM 0.699528894056341 0.260617468513059 no 853 0.242110781159899 1117 41905195 YPL160W CDC60 SGTC_2525 harmine 47.85 µM 0.6987189626474 0.260863337090832 no 854 0.242363840468597 1147 5280953 A monoamine oxidase inhibitor SGTC_2353 9059630 146.67 µM 0.69803058697909 0.261072399094074 no 855 0.24257903286868 1204 4779114 SGTC_1157 4092-0394 27.6 µM 0.697629575883079 0.26119422720083 no 856 0.242704440207511 1266 3659885 SGTC_2766 oltipraz 83.91 µM 0.697286958600773 0.261298338268656 no 857 0.242811613971115 1168 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_116 0155-0182 31.788 µM 0.694855181068756 0.262037894327027 no 858 0.243573031325357 1178 771486 SGTC_1879 gemcitabine 100 µM 0.693827703285943 0.262350694643509 no 859 0.243895133480884 1209 60750 A nucleoside analog which inhibits DNA replication. SGTC_435 c-PAF 6.7 µM 0.693228792530553 0.262533112285488 no 860 0.244082990914139 1177 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_517 1365-0151 113 µM 0.693065148516996 0.262582966653367 no 861 0.24413433390986 1236 768657 SGTC_13 0199-0087 65 µM 0.692801135172103 0.262663408885054 no 862 0.244217179867093 1221 4589825 SGTC_1416 3966-0321 25.3 µM 0.692717691240584 0.262688836040409 no 863 0.244243367272665 1217 582530 YLR208W SEC13 SGTC_495 decylubiquinone 155 µM 0.692653868532289 0.262708285038196 no 864 0.244263397925225 1169 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_989 1501-0895 10.3 µM 0.692227265338552 0.262838304776361 no 865 0.244397309378621 1193 2830112 SGTC_2899 9053889 58.44 µM 0.690424313630151 0.26338816996911 no 866 0.244963695569347 1177 6470052 SGTC_1441 4106-0040 13 µM 0.685027143503313 0.265037705014263 no 867 0.246663396400458 1209 2904180 SGTC_840 0245-0196 390 µM 0.684768830100312 0.26511678464479 no 868 0.24674490368745 1269 3827528 SGTC_3294 9122953 26.2835 µM 0.684378554317417 0.265236285743459 no 869 0.246868077259837 1213 16459826 SGTC_2415 st077333 57.7 µM 0.683797613337882 0.265414218507578 no 870 0.247051486946123 1258 2766255 SGTC_2612 dictamnine 15.46 µM 0.681822499816863 0.266019616333532 no 871 0.24767559764085 1179 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1267 0828-0272 9.49 µM 0.680995549053139 0.266273295005286 no 872 0.247937153397543 1249 745334 SGTC_141 0443-0274 32.331 µM 0.680825755034036 0.266325396834035 no 873 0.247990875679968 1305 1627241 SGTC_2983 9022671 12.99 µM 0.680167583300141 0.266527407648085 no 874 0.248199177792452 1216 6405161 SGTC_1276 0871-0068 94.2 µM 0.679052652962402 0.266869786842293 no 875 0.248552250387389 1187 3414906 SGTC_1052 3253-3998 198 µM 0.677127887939357 0.267461377178221 no 876 0.249162408026949 1212 5450317 SGTC_2763 lisinopril 49.32 µM 0.676464847367834 0.267665320502258 no 877 0.249372778677467 1200 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2549 cedrol 20.94 µM 0.674212276754361 0.268358769140058 no 878 0.25008818280977 1189 6708665 A sedative which affects the nervous system. SGTC_1339 1486-1321 22.7 µM 0.672381600137077 0.268923003478927 no 879 0.250670396718232 1242 3469382 SGTC_856 0433-0016 11.3 µM 0.672333375609224 0.268937874847955 no 880 0.25068574336409 1239 3911780 SGTC_3111 9122088 49.47 µM 0.672297479323748 0.268948944729982 no 881 0.250697167076959 1155 16876704 SGTC_1361 1608-0041 5.61 µM 0.672116941534338 0.269004623374692 no 882 0.250754626000232 1230 X1361 SGTC_830 4076-0286 57.8 µM 0.671791588889665 0.269104978161332 no 883 0.250858192079054 1275 6866659 SGTC_1166 k206-0078 225 µM 0.671256714949402 0.269270000457824 no 884 0.251028502062798 1240 5404595 SGTC_1013 4112-3890 241 µM 0.671198430768693 0.269287985685024 no 885 0.2510470641087 1197 705171 SGTC_3330 9141424 71.43 µM 0.66753078792833 0.270420950622395 no 886 0.252216575263628 1238 27261020 SGTC_43 0570-0105 72.5 µM 0.66724514870167 0.270509286807598 no 887 0.25230777825385 1275 1114046 YDL195W SEC31 SGTC_533 1222-0222 6.71 µM 0.66719345221134 0.270525275895881 no 888 0.252324286508922 1296 3982874 SGTC_371 0195-0006 7.36 µM 0.666918449548789 0.270610338770808 no 889 0.252412112758305 1153 3928593 SGTC_225 nsc-122657 1.016 µM 0.666343700173618 0.270788161390882 no 890 0.252595719654907 1203 275685 SGTC_2288 7946289 167.31 µM 0.666175601957621 0.270840180587091 no 891 0.252649432863021 1274 1246052 SGTC_2718 lomofungin 53.02 µM 0.665911750180174 0.27092184146559 no 892 0.252733754784492 1269 5351222 A RNA synthesis inhibitor. SGTC_896 0964-0007 44.5 µM 0.665574389669216 0.27102627084359 no 893 0.252841590257834 1225 6756758 SGTC_110 0850-0284 111.64 µM 0.665572801889712 0.271026762385531 no 894 0.252842097840274 1114 3906265 SGTC_687 k029-0044 34.9 µM 0.661323891305499 0.272343723172317 no 895 0.254202311524725 1265 5829338 SGTC_2999 9069765 71.4286 µM 0.661066689406421 0.272423545492899 no 896 0.254284773166352 1258 2097066 SGTC_584 0986-0246 15.4 µM 0.660274609662382 0.272669439520553 no 897 0.254538810355978 1332 53315 YDR232W HEM1 SGTC_1397 3532-0190 20.1 µM 0.657926997673825 0.2733988809396 no 898 0.255292520837583 1186 5322280 SGTC_1365 1672-3266 55.4 µM 0.656707582328927 0.273778154135852 no 899 0.255684479044504 1256 6415873 SGTC_1936 st074407 74.3 µM 0.655851436607371 0.274044595434766 no 900 0.255959858682994 1282 809813 SGTC_2238 6671620 73.2395 µM 0.653922755400854 0.274645289790214 no 901 0.256580786326883 1231 729941 SGTC_2616 abietic acid 100 µM 0.653261957578528 0.274851246791734 no 902 0.256793706622955 1267 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_481 bay k-8644 50 µM 0.652927025759945 0.274955667168765 no 903 0.256901662461494 1205 2303 A calcium channel antagonist. SGTC_1048 3161-0300 24.5 µM 0.651917451010304 0.275270536530543 no 904 0.25722721326735 1272 2165101 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.651502285129765 0.275400071258116 no 905 0.25736115123156 1284 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2840 9008771 71.43 µM 0.650464140268483 0.27572411109343 no 906 0.257696228943672 1238 2992978 SGTC_1473 k844-0725 134 µM 0.648276212959992 0.276407649664955 no 907 0.258403158114721 1320 54682906 SGTC_847 0342-0274 5.54 µM 0.647393069304126 0.27668379112781 no 908 0.258688790170662 1276 18097 SGTC_411 enrofloxacin 100 µM 0.64715605220943 0.276757924663118 no 909 0.258765475587284 1354 71188 A bacterial gyrase inhibitor. SGTC_2002 4023503 131 µM 0.646935659040958 0.276826867343855 no 910 0.258836792990123 1322 4736863 YCR052W RSC6 SGTC_2837 9008476 45.46 µM 0.646310349683159 0.27702252038049 no 911 0.259039193266354 1295 2992805 SGTC_1627 st003713 25.6 µM 0.644448300731916 0.27760553741908 no 912 0.25964238607396 1305 16195070 YER133W GLC7 SGTC_3128 9127691 49.47 µM 0.644368029734627 0.27763068415071 no 913 0.259668405382568 1265 41316314 SGTC_720 r052-1644 49.9 µM 0.641511034788489 0.278526427300376 no 914 0.260595356914652 1258 1422863 YOR257W CDC31 SGTC_1715 st032160 10.2275 µM 0.63852440013689 0.279464318423942 no 915 0.261566187914829 1233 5289825 SGTC_224 benfluorex 43.875 µM 0.638250285743026 0.279550475190865 no 916 0.261655384056178 1290 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_342 k048-0088 23.3 µM 0.638197281810449 0.279567136319892 no 917 0.261672633204645 1261 6820570 SGTC_339 3091-4833 71.4 µM 0.63733598165472 0.279837942888852 no 918 0.261953009150616 1256 3240077 SGTC_2241 6772625 37.8075 µM 0.637218848080763 0.279874781387703 no 919 0.261991151117008 1220 2285411 SGTC_1025 k007-0731 70 µM 0.636816108502466 0.280001460893122 no 920 0.262122316104114 1260 6256118 SGTC_1938 st074717 56.4 µM 0.636229356854703 0.280186070112414 no 921 0.262313470700663 1204 17250979 SGTC_3255 9139072 49.47 µM 0.635663276536823 0.28036423140093 no 922 0.262497958544177 1292 17646060 SGTC_1213 1315-0166 115 µM 0.634932506084107 0.280594306361208 no 923 0.262736217740305 1254 768401 SGTC_778 3456-2434 196 µM 0.632495548737633 0.281362214935608 no 924 0.263531558089672 1331 5539063 SGTC_650 1328-0195 38 µM 0.632481560521626 0.281366625682489 no 925 0.263536126913676 1279 2780821 SGTC_1220 1838-0075 193 µM 0.632123017788973 0.281479692319895 no 926 0.263653247753704 1227 5529645 SGTC_2296 7971656 126.45 µM 0.628697543691 0.282561021063054 no 927 0.264773543260719 1291 666570 SGTC_1697 st025554 27.742 µM 0.627942308569448 0.282799696602811 no 928 0.265020866862461 1262 1269519 SGTC_1418 3966-3099 2.4 µM 0.627007571667456 0.283095233793132 no 929 0.265327135968179 1314 740335 SGTC_2262 9014885 67.46 µM 0.621576366212275 0.284815352426446 no 930 0.267110232707528 1261 6457424 SGTC_3212 9128307 49.47 µM 0.617547933649715 0.286094411248331 no 931 0.26843668745445 1259 27243542 SGTC_2373 9071805 200 µM 0.615541324644979 0.286732541916187 no 932 0.269098643552753 1351 10149009 SGTC_1618 st003135 44.5 µM 0.614377692257863 0.287102902687397 no 933 0.269482886717221 1264 1270615 SGTC_2476 5806916 10.51 µM 0.613419019920241 0.28740819887533 no 934 0.269799656474657 1256 2870194 SGTC_1811 st050069 61.5 µM 0.612825014730263 0.287597441171451 no 935 0.2699960244276 1308 3877702 SGTC_2 0422-0095 29 µM 0.611622751471112 0.287980646693674 no 936 0.270393690840915 1210 6790840 SGTC_2297 7971671 152.32 µM 0.611142158801563 0.288133896661874 no 937 0.270552735856339 1376 909016 SGTC_1795 st049545 62.3 µM 0.607391172980583 0.289331320075498 no 938 0.271795672516642 1307 5291882 SGTC_431 k089-0097 107 µM 0.6059075071333 0.289805593755197 no 939 0.272288087058268 1280 5499420 SGTC_2424 5537928 59.2 µM 0.605894365111541 0.289809796407808 no 940 0.272292450749703 1348 5382802 SGTC_1583 clindamycin 39.6 µM 0.605542425958466 0.289922352738546 no 941 0.272409321938314 1264 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_700 3453-2283 142 µM 0.605386914241087 0.28997209465044 no 942 0.272460971866981 1397 565664 SGTC_2138 5575593 77.673 µM 0.604387047656953 0.290292007082744 no 943 0.272793172520604 1315 762213 SGTC_672 1441-0018 53.7 µM 0.604318925936396 0.290313808989424 no 944 0.272815812929491 1298 251141 SGTC_3029 9088683 49.47 µM 0.603753637914125 0.290494755263476 no 945 0.273003723642383 1328 25236615 SGTC_2462 5162487 171.77 µM 0.603308430033495 0.290637301544237 no 946 0.273151762964378 1306 2259986 SGTC_3 0833-0587 95.581 µM 0.602668175497027 0.290842355042479 no 947 0.273364728387507 1262 5382644 SGTC_1625 st003711 30.1 µM 0.602092644389626 0.291026737350468 no 948 0.27355623525286 1415 24207034 YER133W GLC7 SGTC_1613 st002381 52.1 µM 0.601998341321239 0.29105695433345 no 949 0.273587620746699 1327 551167 SGTC_3059 1327-0034 3 µM 0.600835844830365 0.291429566640843 no 950 0.27397466355001 1288 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1738 st035555 74 µM 0.599812152666029 0.291757872468808 no 951 0.274315716630616 1343 5331140 SGTC_3203 9113543 49.47 µM 0.598645717167289 0.292132167091167 no 952 0.274704581369219 1397 17018012 SGTC_527 4476-4215 268 µM 0.597170567672486 0.292605843934182 no 953 0.275196753714875 1366 4418754 SGTC_1143 3454-2408 5.08 µM 0.595568017905531 0.293120833572549 no 954 0.275731923726573 1293 X1143 SGTC_3345 9148410 3.559 µM 0.595549289904259 0.293126854419918 no 955 0.275738180947904 1329 4903596 SGTC_889 0919-1524 82.7 µM 0.595408887078374 0.293171994217886 no 956 0.275785093224984 1325 3905452 SGTC_1027 k015-0025 8.67 µM 0.595255088178191 0.293221444580166 no 957 0.275836485983853 1313 3598955 SGTC_1447 4239-0816 81.9 µM 0.59428703963791 0.293532786193295 no 958 0.276160072774151 1290 1341554 SGTC_2800 7887935 81.82 µM 0.594223755142483 0.293553144941655 no 959 0.276181233186399 1373 2961002 SGTC_189 3970-0742 2.116 µM 0.592919850884698 0.293972758986029 no 960 0.276617396173052 1367 2891807 SGTC_1913 st060213 96.1 µM 0.592457986125824 0.294121459808005 no 961 0.276771973350572 1382 688959 SGTC_2845 9003024 42.97 µM 0.591913445648904 0.294296823334531 no 962 0.27695427482601 1440 2990173 SGTC_335 4077-0256 27.6 µM 0.591796609564864 0.29433445545613 no 963 0.276993396914909 1355 3121989 SGTC_1196 1588-0294 184 µM 0.591369042363167 0.294472190935542 no 964 0.277136589119356 1333 6144269 SGTC_2667 digitoxin 100 µM 0.590284784460221 0.294821604498173 no 965 0.277499869264256 1328 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2286 7945697 125 µM 0.59025284545348 0.29483190007784 no 966 0.277510573942601 1306 1245733 SGTC_314 1671-0008 2.74 µM 0.590011928691118 0.294909565243763 no 967 0.277591326112821 1287 3913060 SGTC_2651 TUB2.036 5 µM 0.589872149269157 0.294954630738774 no 968 0.277638183622334 1437 15992207 YFL037W TUB2 SGTC_422 cantharidin 155 µM 0.588768406852821 0.295310593504898 no 969 0.27800832096001 1300 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2827 7993847 71.43 µM 0.586946952548507 0.295898454054386 no 970 0.278619667263333 1372 2985692 SGTC_3216 9129716 49.47 µM 0.586818495774828 0.295939932781574 no 971 0.278662806729072 1304 8056934 SGTC_2118 5526350 200 µM 0.585738290566426 0.296288836905744 no 972 0.279025699200198 1400 743594 SGTC_2645 abamectin 100 µM 0.585618968686325 0.29632738920143 no 973 0.279065799205002 1337 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2137 5261020 140 µM 0.584928108702724 0.296550647763888 no 974 0.279298028696621 1322 763655 SGTC_1201 1889-3372 45.9 µM 0.583193005313603 0.297111703943788 no 975 0.279881689675063 1316 5392199 SGTC_1558 st069300 45.6 µM 0.582830467757802 0.29722899392791 no 976 0.280003716169887 1365 24208000 SGTC_1314 1222-0010 41.1 µM 0.581167382698397 0.297767314617063 no 977 0.280563824181022 1373 3526027 SGTC_3101 9120531 49.47 µM 0.580662869299202 0.29793070743225 no 978 0.280733845641427 1421 24824904 SGTC_1107 amlodipine 47 µM 0.577908159145861 0.298823573875186 no 979 0.28166306321358 1290 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_252 miconazole 1.30953 nM 0.576353045421147 0.299328159228364 no 980 0.282188287556073 1346 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1324 1418-0026 34.4 µM 0.576339234490442 0.299332642170635 no 981 0.28219295417303 1391 1372513 SGTC_2792 7535235 81.82 µM 0.573110495095942 0.300381505490672 no 982 0.283284940789769 1337 1281891 SGTC_1490 4089-0339 670 nM 0.573091035789661 0.300387831922109 no 983 0.283291528228749 1349 742542 SGTC_1399 3562-5772 25 µM 0.572899824462282 0.30044999999956 no 984 0.283356261727773 1332 23847490 SGTC_1228 0124-0032 52.5 µM 0.572394184147221 0.300614425613963 no 985 0.283527477526303 1474 X1228 SGTC_2400 5203494 178.7 µM 0.570543412453195 0.301216611197812 no 986 0.28415459321806 1345 6777674 SGTC_2820 7989630 71.43 µM 0.570265269755391 0.301307157434187 no 987 0.284248896424527 1299 2984098 SGTC_753 1322-0200 289 µM 0.570260487895008 0.301308714222378 no 988 0.284250517826619 1382 5403907 SGTC_911 3456-4043 236 µM 0.570121778587537 0.301353874166844 no 989 0.28429755239986 1470 914281 SGTC_175 3793-3120 23.7 µM 0.569146360240436 0.301671529638948 no 990 0.284628409449012 1373 5322297 SGTC_1942 st076330 65.2 µM 0.568148348074023 0.301996698787071 no 991 0.284967120368614 1411 24208414 SGTC_1788 fluconazole 20 µM 0.566100233203624 0.302664501575364 no 992 0.285662822392012 1374 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2995 9067767 71.4286 µM 0.565679041246937 0.302801916265068 no 993 0.285805992659674 1398 11673567 SGTC_77 0828-0286 12.516 µM 0.564743258628467 0.303107317095147 no 994 0.286124203067636 1344 745345 SGTC_2207 7258803 200 µM 0.564462939497136 0.303198828502719 no 995 0.286219557597982 1378 3666799 SGTC_3068 9116768 49.47 µM 0.563434381005021 0.303534711700529 no 996 0.286569565583432 1371 41904888 SGTC_1171 0368-0077 21.4 µM 0.562183517988674 0.303943413811898 no 997 0.28699549492625 1365 3239779 SGTC_3178 9107506 49.47 µM 0.561132045813149 0.304287157442812 no 998 0.28735376182518 1404 8897194 SGTC_222 nsc-310342 10.666 µM 0.560091483803766 0.304627504694469 no 999 0.287708519482261 1392 432556 SGTC_2944 9067346 25.62 µM 0.558355262517364 0.305195764922632 no 1000 0.288300907790626 1390 6473075 SGTC_1829 berberine 14.4 µM 0.557171840409636 0.305583364979451 no 1001 0.28870501368101 1484 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_659 k018-0002 107 µM 0.557133950669088 0.305595778411472 no 1002 0.288717956384208 1399 6797879 YHR007C ERG11 SGTC_321 4534-3890 65.3 µM 0.553887471856726 0.306660217983481 no 1003 0.28982792978817 1433 699746 SGTC_2115 tiliquinol 12.7705 µM 0.553279869745298 0.306859617241641 no 1004 0.290035891557515 1425 71208 A bioactive hydroxyquinoline. SGTC_126 0417-1624 672.48 µM 0.55150826445934 0.307441338283374 no 1005 0.290642651438154 1459 41912 YDL195W SEC31 SGTC_3261 9137475 49.47 µM 0.551276283816278 0.307517546937796 no 1006 0.290722146799997 1355 17027690 SGTC_3284 9108171 64.8615 µM 0.550490940311867 0.307775604142 no 1007 0.290991344560642 1422 8687505 SGTC_397 arbidol 50 µM 0.550439478786931 0.307792517283881 no 1008 0.29100898845744 1477 131410 A RNA synthesis inhibitor. SGTC_1785 bathophenanthroline 24 µM 0.549071362992511 0.308242306492494 no 1009 0.291478238441089 1384 72812 An iron chelator. SGTC_2523 spermine 47.74 µM 0.54877078811738 0.308341163748274 no 1010 0.291581379874062 1422 1103 A DNA binding polyamine. SGTC_1540 guanosine 70.6 µM 0.545360670104134 0.309463702956198 no 1011 0.292752742337502 1376 6802 Guanosine is a purine nucleoside SGTC_2533 agelasine 13.65 µM 0.54532405536645 0.309475765436145 no 1012 0.292765331208238 1532 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1402 3909-7673 35.9 µM 0.543973730730916 0.309920764127764 no 1013 0.293229774988582 1391 5328014 SGTC_1506 4226-2149 212 µM 0.543742525713712 0.309996985560781 no 1014 0.293309332125802 1461 991114 SGTC_380 3970-0968 6 µM 0.54184493271152 0.310622873987121 no 1015 0.293962667355276 1373 2891601 SGTC_725 1497-0963 19 µM 0.540707521644946 0.310998292543867 no 1016 0.294354596635596 1524 3549977 SGTC_3085 9117376 49.47 µM 0.540516830026987 0.311061252271084 no 1017 0.294420328792803 1487 16480349 SGTC_1258 0671-0043 57.1 µM 0.535600118484767 0.312686484129597 no 1018 0.296117473426378 1400 4298767 SGTC_458 nppb 133 µM 0.5346232379106 0.313009830045885 no 1019 0.296455205733736 1540 4549 A chloride channel blocker. SGTC_2150 5556613 200 µM 0.532120598319524 0.313838855764703 no 1020 0.297321235923259 1455 743190 SGTC_2040 5100729 123 µM 0.532006964857735 0.313876520402308 no 1021 0.297360585827978 1467 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_467 ro 31-8220 72.8 µM 0.531597338437672 0.314012310153915 no 1022 0.297502454285286 1425 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2664 lyso-paf C-16 73.48 µM 0.531451750321613 0.314060578182069 no 1023 0.297552884162812 1448 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3244 9134489 49.47 µM 0.531040247501412 0.314197024303775 no 1024 0.29769544462127 1388 16584271 SGTC_442 cape 100 µM 0.529547481561603 0.3146922087565 no 1025 0.298212857738791 1530 5281787 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.527701808585709 0.31530492148604 no 1026 0.298853158882917 1389 390807 SGTC_166 k072-0058 166.424 µM 0.52755940568827 0.31535221648015 no 1027 0.298902587264408 1429 5846229 SGTC_562 3772-2733 112 µM 0.526720655215279 0.315630844509053 no 1028 0.29919379485774 1431 2876874 YIL048W NEO1 SGTC_2716 st080858 38.6235 µM 0.526349299759583 0.315754240123544 no 1029 0.299322767670315 1419 5296050 SGTC_836 0330-0104 1.35 µM 0.524452953988298 0.316384686191976 no 1030 0.299981766804894 1455 46494820 SGTC_853 0419-0306 21 µM 0.523996432164831 0.316536538117703 no 1031 0.300140510703179 1383 762713 SGTC_2220 6782180 200 µM 0.522469475160232 0.317044671349476 no 1032 0.300671747136368 1430 833803 SGTC_112 phenothiazine 287.218 µM 0.521392132378358 0.317403391945157 no 1033 0.301046815551951 1495 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1735 st034310 56.75 µM 0.517877531677026 0.318574832678293 no 1034 0.302271859638153 1556 871153 SGTC_809 3998-0021 90 µM 0.51785967360358 0.318580789543752 no 1035 0.302278089930278 1437 715485 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.516919282616304 0.318894539237302 no 1036 0.302606253192911 1597 1273210 SGTC_3118 9124250 49.47 µM 0.516021912739305 0.319194056540341 no 1037 0.302919552388078 1409 1504786 SGTC_2331 7980721 200 µM 0.515864978616732 0.319246448953777 no 1038 0.302974357789891 1524 2981221 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.515739145388294 0.319288460950087 no 1039 0.303018305170769 1466 7104 SGTC_1159 4092-0538 61.2 µM 0.515699106023324 0.319301829397465 no 1040 0.303032289557208 1498 717301 SGTC_2233 sulbentine 40.3845 µM 0.513946214940317 0.319887319304977 no 1041 0.303644797517083 1442 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3094 9117742 49.47 µM 0.513819179148321 0.319929768484923 no 1042 0.303689208758686 1398 17149698 SGTC_2247 cerulenin 830 nM 0.513121215419093 0.320163036054164 no 1043 0.303933265993734 1520 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1133 3473-0247 50 µM 0.512508077321717 0.320368012581577 no 1044 0.304147734352573 1403 711311 SGTC_683 panaxydol 45 µM 0.5120916472422 0.320507259448794 no 1045 0.304293435043925 1469 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1411 3909-8223 150 µM 0.511858932110634 0.3205850862882 no 1046 0.304374871025609 1531 X1411 SGTC_3339 9145883 14.936 µM 0.510147084832304 0.321157821027092 no 1047 0.304974210207877 1483 2030670 SGTC_3024 9090631 49.47 µM 0.5093944390015 0.321409769420862 no 1048 0.305237886743326 1462 25236383 SGTC_3177 9107506 49.47 µM 0.507974035336634 0.321885473784346 no 1049 0.305735776140904 1487 8897194 SGTC_505 gw-5074 63.9 µM 0.507467296128585 0.322055255456829 no 1050 0.305913488771414 1529 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2927 9011802 47.9 µM 0.506352178030188 0.322429003685872 no 1051 0.306304719812603 1408 43912568 SGTC_2043 5101342 149 µM 0.50610159732189 0.322513014214816 no 1052 0.306392664643073 1454 678451 SGTC_2463 5473429 200 µM 0.506019588618104 0.322540510696652 no 1053 0.306421449175952 1483 5399405 SGTC_2773 thioridazine 9.09 µM 0.505727282298436 0.32263852520576 no 1054 0.306524056548789 1473 5452 An antipsychotic. SGTC_631 k072-0230 41.5 µM 0.504666594084435 0.322994292674235 no 1055 0.306896513958011 1512 5773147 SGTC_2125 5246583 200 µM 0.504438394216204 0.323070854817865 no 1056 0.306976671719828 1578 835267 SGTC_2324 6149169 200 µM 0.502263233655903 0.323801007449184 no 1057 0.307741183978619 1461 2888231 SGTC_2069 5228469 200 µM 0.500359539981947 0.324440591771017 no 1058 0.308410968544586 1430 2835210 SGTC_1014 4130-3005 69.3 µM 0.498707339529945 0.324996102028623 no 1059 0.308992786634404 1458 743608 SGTC_2397 5161689 200 µM 0.49806495332946 0.325212193177928 no 1060 0.309219130814053 1561 2259942 SGTC_400 oxethazaine 37.5 µM 0.496253387201076 0.32582189917027 no 1061 0.309857824361575 1477 4621 A local anesthetic. SGTC_1774 st048371 48.465 µM 0.494878973725952 0.326284786880101 no 1062 0.31034277681083 1448 4242727 SGTC_2365 9042475 200 µM 0.494802875661804 0.326310423719404 no 1063 0.310369637142054 1464 6464479 SGTC_3333 9141820 12.094 µM 0.492337215114403 0.327141528850199 no 1064 0.311240487886884 1477 1939433 SGTC_1273 0849-0096 14.1 µM 0.49218291969982 0.327193566077472 no 1065 0.311295018950856 1478 5286025 SGTC_2354 9060492 162 µM 0.49177398529533 0.327331498364239 no 1066 0.3114395645215 1606 6471895 SGTC_568 1193-0097 7.48 µM 0.490936783699047 0.327613957360082 no 1067 0.311735579863768 1438 3646150 SGTC_1163 k060-0048 49.9 µM 0.489293196764294 0.328168765347556 no 1068 0.312317068434675 1487 6809982 SGTC_3063 1327-0034 4 µM 0.489267031061381 0.328177600893043 no 1069 0.312326329447842 1436 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2649 anisomycin 9.56 µM 0.48901912608007 0.328261317372619 no 1070 0.312414078101743 1465 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2124 5246320 200 µM 0.487892180716772 0.328641990803268 no 1071 0.312813106663201 1527 579342 SGTC_561 1550-0330 72.9 µM 0.487849113045282 0.328656542261297 no 1072 0.312828360410797 1468 6812934 SGTC_3170 9103054 49.47 µM 0.487653605342621 0.328722602549948 no 1073 0.312897609538583 1434 16432970 SGTC_600 1495-0418 41.6 µM 0.486654199705972 0.329060376270185 no 1074 0.31325170364375 1509 5377768 SGTC_698 k064-0052 127 µM 0.483251950022462 0.330211295545568 no 1075 0.314458426425068 1573 5088751 SGTC_1976 st070609 63.5 µM 0.482429226148473 0.330489849994981 no 1076 0.314750531785691 1475 682556 SGTC_1134 3477-0009 42.5 µM 0.482369255953772 0.330510158130612 no 1077 0.31477182853905 1686 3973534 SGTC_603 3794-0023 45.9 µM 0.481244987224134 0.330890969609147 no 1078 0.315171195405942 1590 3802260 SGTC_310 1273-0058 1.06 µM 0.480926636989783 0.330998832785646 no 1079 0.315284320227751 1486 2734232 SGTC_73 0327-0325 16.231 µM 0.480906585002017 0.331005627254135 no 1080 0.31529144622273 1555 53298 SGTC_1137 ixabepilone 100 µM 0.479528064942423 0.331472861962378 no 1081 0.315781503780179 1476 154225 A novel microtubule stabilizer. SGTC_3306 9127676 59.7925 µM 0.47857324566658 0.331796641662992 no 1082 0.316121127655079 1501 41905287 SGTC_426 0988-0037 14.6 µM 0.478389988748456 0.331858798559545 no 1083 0.316186328878257 1522 5383008 SGTC_81 0411-0046 9.971 µM 0.478312495443158 0.331885084053119 no 1084 0.316213902044454 1446 12925265 SGTC_1145 3546-0597 10.2 µM 0.477197231337569 0.332263469844927 no 1085 0.316610841233956 1504 875334 SGTC_2891 9063876 19.48 µM 0.474929462703687 0.33303340353483 no 1086 0.317418625311668 1545 6472478 SGTC_2249 haloperidol 116.36 µM 0.474396106098607 0.333214586704799 no 1087 0.317608734642347 1559 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2810 7959871 45.46 µM 0.474219737846029 0.333274508205921 no 1088 0.317671609830236 1597 2974535 SGTC_589 1227-0070 34.1 µM 0.473992221794832 0.333351813569642 no 1089 0.317752726948567 1521 2841384 SGTC_512 prima-1 270 µM 0.473184626872642 0.333626275171714 no 1090 0.318040732295808 1588 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3026 9090633 49.47 µM 0.472396700883415 0.333894138116616 no 1091 0.318321829379697 1490 25236842 SGTC_1786 berberine 21.6 µM 0.468365866217197 0.335265780627114 no 1092 0.319761486726065 1479 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3176 9106582 49.47 µM 0.467689183915689 0.335496263211792 no 1093 0.320003438508112 1496 17018027 SGTC_165 k038-0023 64.381 µM 0.464253979414661 0.336667270653957 no 1094 0.321232895722425 1483 46368543 SGTC_1363 1636-0063 10.4 µM 0.464067564474346 0.336730862042969 no 1095 0.32129966973059 1542 6072185 SGTC_1020 4335-0961 93.3 µM 0.463869673391672 0.336798373375916 no 1096 0.321370560824985 1468 669075 SGTC_638 3970-0837 4.09 µM 0.463318631259477 0.336986391304632 no 1097 0.321567996524454 1500 4118451 YLR208W SEC13 SGTC_202 3594-0513 34.79 µM 0.462762325189293 0.337176246634001 no 1098 0.321767369405033 1536 708429 SGTC_2318 6029776 164 µM 0.46276222614802 0.337176280438357 no 1099 0.321767404904712 1617 818325 SGTC_955 1216-0110 33 µM 0.462201653135091 0.337367633946367 no 1100 0.321968358936073 1466 3619719 SGTC_546 peri-Naphthalide 147 µM 0.461590693913176 0.337576234871674 no 1101 0.322187434702201 1620 223824 A penicillin ester. SGTC_1944 st076371 56.9 µM 0.461518088540475 0.337601027976713 no 1102 0.322213473409204 1491 24208455 SGTC_155 k072-0202 43.6 µM 0.459910471982935 0.338150173370743 no 1103 0.322790241648032 1498 5857737 SGTC_515 4092-1064 102 µM 0.45910876975581 0.33842415548474 no 1104 0.323078029663262 1667 717353 SGTC_232 clozapine 119 µM 0.458733456070018 0.338552448525212 no 1105 0.323212792886953 1560 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1640 st009078 66.4 µM 0.458727298412596 0.338554553546362 no 1106 0.323215004099666 1616 690618 SGTC_679 0422-0091 41.4 µM 0.458681892970913 0.338570075743749 no 1107 0.323231309371361 1496 627384 YHR062C RPP1 SGTC_900 1112-0045 141 µM 0.458629648701366 0.338587936186033 no 1108 0.323250070913049 1472 56211 YIL048W NEO1 SGTC_883 0850-0245 24.6 µM 0.458434855717965 0.338654532121705 no 1109 0.323320027364299 1614 6823229 YPR165W RHO1 SGTC_2777 climbazole 1.536 µM 0.456315851938865 0.339379303888747 no 1110 0.324081433234298 1567 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3351 9150312 21.596 µM 0.453524380327584 0.340334989936035 no 1111 0.32508559584328 1532 4904905 SGTC_699 0375-0592 111 µM 0.452444886106885 0.340704840285315 no 1112 0.32547425850952 1596 762578 SGTC_2676 harmalol 100 µM 0.45163296056459 0.340983118699292 no 1113 0.325766710491818 1608 5459187 A monoamine oxidase inhibitor SGTC_2520 obtusaquinone 4.71 µM 0.451219157468615 0.341124978389362 no 1114 0.325915801805962 1647 5967872 SGTC_2834 9001755 58.44 µM 0.448029938708205 0.342219056436053 no 1115 0.327065794967263 1578 2989575 SGTC_2704 st078022 71.1 µM 0.44764150507291 0.342352401359696 no 1116 0.327205971892601 1674 54697681 SGTC_912 3474-0017 2.18 µM 0.446933793616591 0.342595401309124 no 1117 0.327461431624601 1655 3360550 SGTC_3262 9137218 49.47 µM 0.446863918673017 0.342619397119713 no 1118 0.327486658484522 1506 17650664 SGTC_247 mechlorethamine 29.705 µM 0.44613904560434 0.342868363816341 no 1119 0.327748404918093 1571 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1539 benzyladenosine 56 µM 0.445806111711475 0.342982736993822 no 1120 0.327868653322867 1525 92208 A nucleotide analog. SGTC_1424 4048-1941 275 µM 0.445553818157531 0.343069417283389 no 1121 0.327959788097907 1670 X1424 SGTC_2491 paeonol 100 µM 0.444962579005862 0.343272581182288 no 1122 0.328173398673043 1529 11092 Increases levels of cortical cytochrome oxidase. SGTC_2256 7954252 200 µM 0.444806023458616 0.343326384997347 no 1123 0.328229970512581 1532 2972920 SGTC_1692 fluoroquinolonic acid 71 µM 0.444360223417686 0.343479611543868 no 1124 0.328391083337603 1600 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.443453586761702 0.343791312218902 no 1125 0.328718841667971 1688 6728940 SGTC_2919 7978188 46.38 µM 0.44322852867349 0.343868703403147 no 1126 0.328800222873585 1681 2980291 SGTC_2674 ligustilide 100 µM 0.440508939393839 0.344804410476108 no 1127 0.329784269595449 1572 5319022 A signalling regulator. SGTC_25 0118-0223 35.662 µM 0.439770179028659 0.345058754114757 no 1128 0.330051784058403 1617 5333628 SGTC_1764 st044502 93.5 µM 0.43906219620414 0.345302567232159 no 1129 0.33030823515534 1556 8407 SGTC_2182 6325192 200 µM 0.438932955475647 0.345347081721552 no 1130 0.330355058355412 1551 736248 SGTC_16 erodoxin 22.806 µM 0.437593709257204 0.345808485233431 no 1131 0.330840416103179 1574 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2836 9010338 19.48 µM 0.437257636997809 0.345924306440408 no 1132 0.330962257119233 1443 2994051 SGTC_1494 4358-1428 177 µM 0.43723164574748 0.345933264454063 no 1133 0.330971680839883 1696 1564571 SGTC_957 1187-1561 14.1 µM 0.437049398240986 0.345996079385288 no 1134 0.331037761838193 1554 1538454 SGTC_2212 7123476 200 µM 0.43654568154072 0.346169716585512 no 1135 0.331220431504622 1610 1085715 SGTC_46 0329-0187a 2.197 µM 0.436353224713931 0.346236067308227 no 1136 0.331290235360855 1649 46494817 SGTC_1275 0867-0008 21.1 µM 0.435674432751895 0.346470122849008 no 1137 0.331536479163714 1590 3422836 SGTC_3151 9099821 49.47 µM 0.435187702388255 0.346637989366678 no 1138 0.331713094063199 1523 17174189 SGTC_1713 st033146 12.748 µM 0.434090964737146 0.347016349240405 no 1139 0.332111193187957 1687 674619 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.432492110517407 0.347568205902867 no 1140 0.332691892530979 1632 77254 SGTC_2874 9043904 71.43 µM 0.432397065185293 0.34760102170909 no 1141 0.332726425388533 1564 4463428 SGTC_2420 aureobasidin a 50 nM 0.426401341645097 0.34967343306071 no 1142 0.334907711972774 1713 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3235 9132602 49.47 µM 0.425548177157481 0.349968694020317 no 1143 0.335218554536269 1626 4912240 SGTC_1225 1216-0074 20.6 µM 0.425198460267459 0.35008974936745 no 1144 0.335346003267277 1567 4241466 SGTC_186 3455-3465 67.277 µM 0.425008968339342 0.350155348821509 no 1145 0.335415068489625 1576 755278 SGTC_2205 7238770 200 µM 0.424085730980222 0.350475024607799 no 1146 0.335751645699814 1632 279867 SGTC_2130 NSC 7 2.4545 µM 0.42373646076532 0.350595988885452 no 1147 0.335879010706342 1710 21448 SGTC_12 0849-0099 9.267 µM 0.423433510813511 0.350700923134736 no 1148 0.33598949981588 1649 6071388 SGTC_1498 4478-3555 97.6 µM 0.422441405645878 0.351044643128299 no 1149 0.336351430424211 1634 3437919 SGTC_273 hydroxyurea 18.1 mM 0.422238771765837 0.351114861691108 no 1150 0.336425372105679 1612 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.417685800419856 0.35269393567548 no 1151 0.338088427745956 1752 551469 SGTC_292 k038-0015 474 µM 0.417239768247916 0.352848766886388 no 1152 0.338251519826989 1624 46368540 SGTC_478 N-arachidonylglycine 10 µM 0.41434891068599 0.353852860577312 no 1153 0.339309299332425 1619 5283389 SGTC_3084 9116877 49.47 µM 0.413622223471573 0.354105424190657 no 1154 0.339575397573281 1680 27241325 SGTC_737 1950-0117 57.9 µM 0.413366016328149 0.354194485520122 no 1155 0.339669234555236 1689 5393513 SGTC_265 mycophenolic acid 32.932 µM 0.412691610799037 0.354428956808695 no 1156 0.339916286015451 1682 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_507 nimesulide 162 µM 0.412305292653286 0.354563293314063 no 1157 0.340057834912147 1701 4495 A COX2 inhibitor. SGTC_2268 7933382 153.85 µM 0.411809836611032 0.354735607411619 no 1158 0.340239405478946 1583 935025 YOR257W CDC31 SGTC_2760 etidronate 98.04 µM 0.411777909336505 0.354746712382249 no 1159 0.3402511071893 1578 3305 A chelator and antioxidant. SGTC_2993 9054257 71.4286 µM 0.410945829828254 0.355036170456877 no 1160 0.340556128043291 1571 6470217 YGL055W OLE1 SGTC_2692 st077426 47.7 µM 0.408884703677194 0.355753540870915 no 1161 0.341312137469213 1697 25238571 SGTC_492 tmb-8 126 µM 0.408172884632901 0.356001406795263 no 1162 0.341573376885129 1668 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3347 9188721 44.724 µM 0.407780727247748 0.356137987813276 no 1163 0.341717332090348 1639 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2340 7987427 183.45 µM 0.406742246390432 0.356499760232892 no 1164 0.34209865428771 1645 2239331 SGTC_887 0885-0007 9.62 µM 0.406338158319231 0.356640566090527 no 1165 0.342247075883639 1687 5719458 SGTC_3328 9140624 29.0385 µM 0.405917764522352 0.356787074471351 no 1166 0.342401512441571 1735 4904392 SGTC_3150 9097574 49.47 µM 0.404851501070466 0.357158764892945 no 1167 0.342793334886963 1750 17217476 SGTC_280 3448-3607 3.04 µM 0.404504095623318 0.357279896797331 no 1168 0.342921033376633 1702 626179 SGTC_2350 9023895 38.85 µM 0.4034618874496 0.357643375920565 no 1169 0.343304233468333 1691 2997209 SGTC_235 0330-0087 5 mM 0.402943329791665 0.357824275529374 no 1170 0.343494957306543 1608 46494818 YHR062C RPP1 SGTC_1209 2323-2347 50.3 µM 0.402790218152815 0.357877694860618 no 1171 0.343551278897963 1668 5412760 SGTC_2759 disulfiram 3.38 µM 0.402566284173934 0.357955828507951 no 1172 0.343633658499272 1567 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1066 ketoconazole 628 nM 0.402355277743917 0.358029457001014 no 1173 0.343711289181002 1701 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2060 5238662 140 µM 0.40020739944415 0.358779236780547 no 1174 0.344501882535933 1612 790130 SGTC_2143 5623677 140.463 µM 0.399822061765232 0.358913807864356 no 1175 0.344643790060104 1643 5375313 SGTC_1429 4049-0205 9.46 µM 0.398614217703516 0.359335735420174 no 1176 0.345088741937808 1638 22774478 SGTC_2176 5809774 33.9695 µM 0.396304746411331 0.360142963893526 no 1177 0.345940113080785 1755 2870539 SGTC_2395 5646831 180.19 µM 0.396128501795353 0.360204592267252 no 1178 0.346005116544258 1689 6808628 SGTC_1078 idebenone 36.1 µM 0.395181366578092 0.3605358441626 no 1179 0.346354521607781 1637 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_157 1348-1695 65.819 µM 0.394637177910419 0.360726216553289 no 1180 0.34655533594626 1623 5380510 SGTC_2376 9072922 81.32 µM 0.394397974013336 0.360809907679422 no 1181 0.346643619666336 1649 17087968 SGTC_2769 toremifene 3.73 µM 0.394146883005961 0.360897764962457 no 1182 0.346736299559167 1655 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_786 4544-0069 423 µM 0.392631818114207 0.36142804505002 no 1183 0.347295717776037 1705 748821 YLR208W SEC13 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.392384425026998 0.361514659154614 no 1184 0.347387096134279 1651 368090 SGTC_2203 7227154 166.4 µM 0.391345857071925 0.361878346677605 no 1185 0.347770803564351 1645 896304 SGTC_3346 9158254 43.5805 µM 0.389827343658882 0.362410326845281 no 1186 0.348332111442121 1634 17639500 SGTC_1127 asiatic acid 681.4 nM 0.38951935294081 0.362518257559131 no 1187 0.348445998638225 1598 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_451 chloral hydrate 100 µM 0.385895015780237 0.363789170756896 no 1188 0.34978721105117 1689 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2689 tacrolimus 100 µM 0.384308239478873 0.364346064095681 no 1189 0.35037500090896 1644 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_23 0213-0011 39.996 µM 0.383807095744561 0.364522004557001 no 1190 0.350560714242376 1749 627608 SGTC_518 1021-0119 62.6 µM 0.383388631771341 0.364668939856535 no 1191 0.350715815565474 1587 1097762 SGTC_2998 9066762 71.4286 µM 0.382784629508014 0.364881058291439 no 1192 0.350939729490717 1748 4945196 SGTC_2972 9093619 59.92 µM 0.382614796496528 0.364940709084851 no 1193 0.351002698809197 1588 25236256 SGTC_2857 9024691 58.44 µM 0.382228904307246 0.365076258932224 no 1194 0.351145792021721 1645 16478292 SGTC_254 nsc-64875 3.808 µM 0.38147440962412 0.365341334086426 no 1195 0.351425628194264 1771 56993 SGTC_1870 st057514 26.5 µM 0.38108218513629 0.365479158980828 no 1196 0.351571133018191 1634 5393161 SGTC_3190 9110366 49.47 µM 0.380484926401757 0.365689064812175 no 1197 0.351792741849509 1783 17123768 SGTC_2885 9057732 51.95 µM 0.380423841295263 0.365710535364336 no 1198 0.351815409907074 1663 6471414 SGTC_361 000s-0510 1.45 µM 0.380331578041938 0.365742965392291 no 1199 0.351849648854358 1653 660 SGTC_951 1171-0579 82.7 µM 0.379990850371864 0.36586273761428 no 1200 0.351976103501718 1579 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2421 5690543 90.72 µM 0.379818131849156 0.365923456437123 no 1201 0.352040210977733 1686 3397993 SGTC_1243 0416-0003 5.65 µM 0.379625494954396 0.365991181482188 no 1202 0.35211171646418 1639 2141977 SGTC_1747 st037496 66.6 µM 0.379624687973174 0.365991465200071 no 1203 0.352112016021043 1649 723305 SGTC_2959 9079155 11 µM 0.378969181894244 0.366221951752242 no 1204 0.352355374589463 1678 16189457 SGTC_2597 laccaic acid a 100 µM 0.378886867559556 0.36625089821848 no 1205 0.352385938304161 1663 5491415 A textile dye. SGTC_3270 9137563 49.47 µM 0.37754353296728 0.366723399566636 no 1206 0.352884859588731 1713 17015724 SGTC_66 0109-0187 42.4 µM 0.375764038569769 0.367349625717164 no 1207 0.35354616241799 1579 759417 SGTC_1174 0739-0097 51.1 µM 0.375719760309454 0.367365212293645 no 1208 0.35356262292995 1675 728447 SGTC_360 0957-0399 1.01 µM 0.3748048428465 0.36768732511019 no 1209 0.353902806164 1763 6752301 YPR165W RHO1 SGTC_2185 6113692 200 µM 0.373551367331354 0.368128784358814 no 1210 0.354369060918184 1679 874150 SGTC_1849 st056239 19.2 µM 0.373507159146809 0.368144357141966 no 1211 0.35438550900807 1561 5393181 SGTC_2063 5246145 200 µM 0.372908952784682 0.368355102716668 no 1212 0.354608104260106 1705 711240 SGTC_3117 9124945 49.47 µM 0.372840956765579 0.368379059935395 no 1213 0.354633409026209 1578 17592065 SGTC_2211 7117706 200 µM 0.372460483463093 0.368513122549009 no 1214 0.354775014267105 1746 822771 SGTC_2447 5741742 33.78 µM 0.372196042459521 0.368606309744258 no 1215 0.354873446219826 1740 1776504 SGTC_1928 4'-methoxychalcone 40.3 µM 0.371319772921347 0.368915156318185 no 1216 0.35519968618623 1846 641818 SGTC_3155 9099265 49.47 µM 0.37038706038184 0.369243989593392 no 1217 0.355547056833336 1708 25236499 SGTC_662 k832-1615 104 µM 0.370307334249674 0.369272101951853 no 1218 0.355576754852744 1719 5878478 SGTC_274 sirtinol 40.1 µM 0.368840114845083 0.369789585201014 no 1219 0.356123451103225 1611 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2473 5854593 8.94 µM 0.368415411073735 0.369939420829039 no 1220 0.356281753983822 1654 2872951 SGTC_3153 9100258 49.47 µM 0.367889818320705 0.370124877458782 no 1221 0.356477696231689 1631 25236848 SGTC_3272 9137413 49.47 µM 0.36630576210795 0.370683997903143 no 1222 0.357068465210471 1579 17614870 SGTC_686 1319-0111 510 µM 0.365997632277918 0.370792789513205 no 1223 0.357183421176498 1777 4562600 SGTC_2634 4'-methoxyflavone 100 µM 0.365965473525992 0.370804144421256 no 1224 0.357195419595047 1666 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_860 0443-0016 25.1 µM 0.365887213229851 0.370831777756828 no 1225 0.357224619072773 1693 5337942 SGTC_1252 0493-0875 34.8 µM 0.361440209023961 0.372403084106149 no 1226 0.358885197117867 1646 3960963 SGTC_701 4424-0219 185 µM 0.360997580951776 0.372559599281451 no 1227 0.359050627716935 1790 2911779 SGTC_1224 0823-0416 294 µM 0.360907140242994 0.372591582092475 no 1228 0.35908443284969 1753 3598164 SGTC_1634 st006576 41 µM 0.359872375989724 0.372957571262569 no 1229 0.359471287849077 1831 3915356 SGTC_2795 7780010 54.55 µM 0.358919777758312 0.373294600265654 no 1230 0.359827551801534 1692 953673 SGTC_40 0327-0103 19.753 µM 0.35848412931382 0.373448764897162 no 1231 0.359990521374147 1646 409036 SGTC_2029 5175081 200 µM 0.358147768534921 0.373567808070507 no 1232 0.360116366329187 1665 1380876 SGTC_1401 3807-4679 7.6 µM 0.357430823356358 0.373821586078794 no 1233 0.360384652506393 1675 3291456 SGTC_1723 st034307 2.5525 µM 0.354280629530155 0.374937311229664 no 1234 0.361564291483097 1656 867466 SGTC_1265 0819-1001 68.8 µM 0.354248262707859 0.374948780255048 no 1235 0.361576418596378 1670 3106768 SGTC_2385 9074692 200 µM 0.353615154802182 0.375173141174235 no 1236 0.361813657697882 1664 17046906 SGTC_1662 st014054 52 µM 0.352183001642608 0.375680823666688 no 1237 0.362350512037367 1706 2838777 SGTC_2481 5478948 45.16 µM 0.351965653840259 0.375757889903871 no 1238 0.362432010336069 1689 77792 SGTC_2847 9005661 71.43 µM 0.351094706991225 0.37606675614169 no 1239 0.362758649359508 1719 2991449 SGTC_2126 5251174 33.877 µM 0.350763115866699 0.376184370080315 no 1240 0.362883035227144 1884 790722 SGTC_1633 st005664 67.9 µM 0.34958538816362 0.376602197892868 no 1241 0.363324939198151 1651 2063822 SGTC_2127 5253358 187.912 µM 0.349489003706326 0.376636399053046 no 1242 0.363361112390369 1648 20612 SGTC_3200 9114385 49.47 µM 0.346907769930969 0.37755268611346 no 1243 0.364330304585159 1632 17018030 YLR208W SEC13 SGTC_483 fpl-64176 144 µM 0.343196673635403 0.378871259411869 no 1244 0.365725253471271 1740 3423 SGTC_2123 5259487 200 µM 0.342602538352215 0.37908249043284 no 1245 0.365948746098747 1811 2173474 SGTC_3126 9127922 49.47 µM 0.339629980348827 0.380139855632679 no 1246 0.367067598874515 1746 45595682 SGTC_576 1073-0113 22.7 µM 0.339093948520174 0.380330622530427 no 1247 0.367269478524133 1805 5439563 SGTC_537 1334-0398 209 µM 0.338983895406031 0.380369792634854 no 1248 0.36731093113534 1847 5846986 SGTC_1419 3993-2473 62.6 µM 0.337964375556163 0.380732718411925 no 1249 0.367695016994162 1748 704026 SGTC_2315 7733312 200 µM 0.337218467211429 0.380998311259371 no 1250 0.367976108481125 1676 726316 SGTC_1453 4237-0541 195 µM 0.337146714978057 0.381023862772222 no 1251 0.368003151648962 1854 739892 SGTC_1659 st012954 42.1 µM 0.337113129384446 0.381035823034315 no 1252 0.368015810167465 1765 24207262 SGTC_1279 0874-0590 65.2 µM 0.336484416220116 0.381259736848657 no 1253 0.368252800625685 1755 3523074 SGTC_419 nsc-638432 893 µM 0.335727305930721 0.381529431571794 no 1254 0.368538256312999 1710 368090 SGTC_1076 itraconazole 331 nM 0.335029965554839 0.381777886201782 no 1255 0.368801240964162 1726 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2366 9070441 60.58 µM 0.334841716418638 0.381844965631537 no 1256 0.368872245001177 1650 6837235 SGTC_1588 farnesol 29.9 µM 0.334034145210239 0.382132770351104 no 1257 0.369176896444054 1697 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1112 tnp00069 1.16933 µM 0.333983037436985 0.382150986490386 no 1258 0.369196179315293 1820 145826 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.333697581599982 0.382252735169523 no 1259 0.369303887342916 1815 688662 SGTC_1383 3049-0032 20.7 µM 0.333596724473799 0.382288686910825 no 1260 0.369341945147537 1844 712864 SGTC_3083 9117465 49.47 µM 0.333296813065079 0.382395599950662 no 1261 0.369455122402359 1673 16420915 SGTC_1186 1319-0216 26 µM 0.333019525328021 0.382494456034021 no 1262 0.369559772251788 1872 4565136 SGTC_2819 7996655 46.38 µM 0.331820267281029 0.382922092629874 no 1263 0.370012489733453 1808 6456960 SGTC_3249 9135183 49.47 µM 0.330238738256977 0.383486259239774 no 1264 0.370609789138074 1777 4902779 SGTC_2146 5545642 200 µM 0.327770587536331 0.384367196934381 no 1265 0.371542563807171 1732 825326 SGTC_1327 1436-0082 2.18 µM 0.3275673106966 0.384439777640006 no 1266 0.371619420825254 1754 15992205 SGTC_428 3448-4153 16.5 µM 0.326716261027424 0.384743691858079 no 1267 0.371941250053677 1649 3834874 SGTC_503 tyrphostin 8 294 µM 0.326279559608135 0.384899667695384 no 1268 0.372106425914171 1824 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2681 menadione 3.18 µM 0.32591896743209 0.385028473777876 no 1269 0.372242832320375 1760 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2839 9003951 25.97 µM 0.325633314346468 0.385130520093094 no 1270 0.372350901816626 1799 2990634 SGTC_1632 st005650 90 µM 0.321668646781721 0.386547670995087 no 1271 0.373851866330907 1748 2759605 SGTC_3226 9131256 49.47 µM 0.320242035136464 0.387057977814607 no 1272 0.374392430125001 1745 17178073 SGTC_848 0368-0089 85.6 µM 0.317565606865922 0.388015877112587 no 1273 0.375407233166546 1834 762535 SGTC_2097 5376186 200 µM 0.317520632247765 0.388031979463431 no 1274 0.375424293275695 1840 742755 SGTC_706 4262-0057 46.9 µM 0.317006848072736 0.388215944275278 no 1275 0.375619203019831 1709 883298 SGTC_987 1497-1013 404 µM 0.315996177845202 0.388577896549618 no 1276 0.376002704624863 1779 1676435 SGTC_2046 4110841 106 µM 0.315883285501361 0.388618332804023 no 1277 0.376045549548273 1873 44119630 YMR134W ERG29 SGTC_2696 st077691 74.316 µM 0.31556809109192 0.388731236850776 no 1278 0.376165180275989 1771 757133 SGTC_3100 9120536 49.47 µM 0.312547582521084 0.389813671851751 no 1279 0.377312203608175 1868 16421196 SGTC_1165 k072-0275 30.3 µM 0.312373996244339 0.389875904612296 no 1280 0.377378155155522 1816 6153523 YGL055W OLE1 SGTC_1742 st038235 28.8875 µM 0.311678755932274 0.390125184877983 no 1281 0.377642337292347 1760 564103 YBR002C RER2 SGTC_1807 st050092 58.9 µM 0.31123057879601 0.390285903944906 no 1282 0.377812669041674 1754 5008496 SGTC_993 3909-8757 62.7 µM 0.310044361033849 0.390711379335379 no 1283 0.378263611059771 1771 4288324 YLR208W SEC13 SGTC_2918 7977171 22.06 µM 0.309431452332072 0.39093127019341 no 1284 0.378496674025288 1754 2236483 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.309248499981794 0.390996914054734 no 1285 0.378566251549907 1848 17037758 SGTC_1138 3761-0006 1.03 µM 0.308318392701622 0.391330687376889 no 1286 0.378920035975482 1801 12061087 SGTC_3199 9111318 49.47 µM 0.306628235905396 0.391937412707237 no 1287 0.379563179571952 1839 8548020 SGTC_1029 k015-0030 64.7 µM 0.305973995297999 0.392172339884472 no 1288 0.379812222790268 1808 2208316 SGTC_2602 kawain 100 µM 0.305412585719204 0.39237396428924 no 1289 0.380025968703249 1820 5369129 SGTC_1876 myriocin 605 nM 0.30266160861111 0.393362365801444 no 1290 0.381073879079077 1892 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3181 9108277 49.47 µM 0.302056414413783 0.39357989917624 no 1291 0.38130452883709 1741 17097298 SGTC_1776 st049249 45.9 µM 0.301324949633393 0.39384286407861 no 1292 0.381583358727733 1714 1822314 SGTC_1070 indatraline 8.81 µM 0.301030569214924 0.39394870884234 no 1293 0.381695592092033 1742 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3001 9076041 71.4286 µM 0.300737881550932 0.394053952741407 no 1294 0.381807189949591 1768 16004211 SGTC_2456 5770359 74.46 µM 0.300569950440875 0.39411434048405 no 1295 0.381871224251893 1864 3118787 SGTC_183 3914-0051 30.55 µM 0.299152541207052 0.394624139726535 no 1296 0.382411829319701 1926 1596232 SGTC_635 k038-0028 24.7 µM 0.2988849455014 0.394720406093477 no 1297 0.382513917059755 1825 4035102 SGTC_3219 9131112 49.47 µM 0.295648961303705 0.395885044327805 no 1298 0.383749089223422 1829 17612988 YMR079W SEC14 SGTC_865 0488-0499 301 µM 0.292924059504072 0.396866464661457 no 1299 0.384790099123492 1938 9634651 SGTC_2977 9011197 71.43 µM 0.292497190736412 0.397020268174106 no 1300 0.384953253742675 1858 2704722 SGTC_1337 1486-1011 40.3 µM 0.291064468152472 0.39753660414421 no 1301 0.38550100713974 1857 X1337 SGTC_535 2293-4129 48.2 µM 0.290224629392156 0.397839355467006 no 1302 0.385822197584939 1913 396118 YIL048W NEO1 SGTC_2435 5706476 10.6 µM 0.288994284043875 0.398282990564453 no 1303 0.386292875849369 1946 5725375 SGTC_931 2812-0076 566 µM 0.288890688740441 0.398320350731435 no 1304 0.386332514694745 1761 3450959 SGTC_1700 st030840 7.9285 µM 0.288754841376138 0.398369343556109 no 1305 0.386384495998224 1925 5499307 SGTC_2295 7971645 200 µM 0.288667652153959 0.398400788854797 no 1306 0.386417859585332 1849 2978226 YKL099C UTP11 SGTC_1933 st074711 15.9 µM 0.286798160734385 0.399075190186809 no 1307 0.387133435665788 1853 17250958 SGTC_2364 9055074 200 µM 0.285929437756223 0.399388676458581 no 1308 0.387466083247798 1750 6470630 SGTC_1501 4491-0275 38.4 µM 0.285323061767418 0.399607530992244 no 1309 0.387698323060375 1913 5104718 SGTC_996 3970-0799 1.8 µM 0.285273243655895 0.399625512856125 no 1310 0.387717405004456 1927 6615648 YGL040C HEM2 SGTC_2552 juarezic acid 87.02 µM 0.283685596278655 0.400198686014884 no 1311 0.388325666975497 1850 1549512 SGTC_263 alizarin 107.927 µM 0.283071818248612 0.400420330134659 no 1312 0.388560892105294 1828 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1950 st077106 7.18 µM 0.281753168559957 0.400896621982175 no 1313 0.389066391338099 1764 13831864 SGTC_3324 9138759 60.749 µM 0.281720252446551 0.40090851305991 no 1314 0.389079012008613 1833 45595710 SGTC_3019 9081971 49.47 µM 0.281613995352017 0.400946899487156 no 1315 0.389119753819501 1927 16451803 SGTC_1673 st016611 27.3 µM 0.279826141440619 0.401592922550915 no 1316 0.389805447304543 1893 5226799 SGTC_1421 4029-0249 71.4 µM 0.279286915993368 0.401787819143045 no 1317 0.390012323242943 1945 2894095 SGTC_3194 9111903 49.47 µM 0.279099759373528 0.401855470379266 no 1318 0.39008413389419 1860 17087251 SGTC_1914 st062367 72.6 µM 0.27873651253096 0.401986781088381 no 1319 0.390223519803006 1778 978205 SGTC_990 3985-0011 41.3 µM 0.278161981067358 0.40219449201236 no 1320 0.390444009137772 1813 5399565 YGL099W LSG1 SGTC_3310 9130229 44.1445 µM 0.273625587824325 0.4038355042677 no 1321 0.392186183978003 1906 7761258 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.273523822782165 0.40387233667853 no 1322 0.392225291176491 1794 6857784 SGTC_248 streptozotocin 5.23457 mM 0.273172937659499 0.403999341096511 no 1323 0.39236014085663 1944 5300 DNA alkylating agent. SGTC_2151 5563267 85.4165 µM 0.273166555737807 0.40400165115497 no 1324 0.392362593631219 1819 5310824 SGTC_109 0132-0036 33.701 µM 0.273120277672795 0.404018402484722 no 1325 0.392380379884915 1941 67274 A color developer. SGTC_1899 st063254 59.6 µM 0.272797197623552 0.404135353081011 no 1326 0.392504556932396 1742 3093813 SGTC_3254 9136651 49.47 µM 0.272518956622334 0.404236079417651 no 1327 0.39261150869321 1815 16454030 SGTC_1199 1638-0010 4.46 µM 0.272152979632757 0.404368576824014 no 1328 0.392752197229323 1780 3111136 SGTC_1410 3909-8106 77.9 µM 0.272046865093857 0.404406996321877 no 1329 0.392792992303733 1917 1039210 SGTC_904 1141-0088 396 µM 0.271925942960333 0.404450778134852 no 1330 0.392839481501434 1765 1378119 SGTC_3016 9080866 49.47 µM 0.271921464079032 0.404452399809205 no 1331 0.392841203462028 1798 17066299 SGTC_1056 3448-1962 115 µM 0.270012480228635 0.405143737169455 no 1332 0.393575326132088 1848 715507 SGTC_2729 fluphenazine 10.66 µM 0.269816480015992 0.405214735327401 no 1333 0.393650721836006 1806 3372 An atypical antipsychotic. SGTC_948 3448-0295 75.3 µM 0.268527340437689 0.405681784568382 no 1334 0.394146716379276 1810 678569 SGTC_755 1995-0008 37.3 µM 0.268036668502604 0.405859588039543 no 1335 0.394335546841713 1935 689533 SGTC_3253 9135987 49.47 µM 0.266038143635421 0.406583988410928 no 1336 0.395104916416239 1882 4182430 SGTC_1088 bifonazole 369 nM 0.265607859731481 0.406739994277731 no 1337 0.395270615891572 1883 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_111 0083-0039 52.457 µM 0.264281354962271 0.407221031474685 no 1338 0.395781563136021 1887 759313 SGTC_1438 4092-1045 4 µM 0.262377767381048 0.407911583541948 no 1339 0.396515105742746 1839 1351342 SGTC_1036 k216-0215 33.5 µM 0.260556636313747 0.408572491286096 no 1340 0.397217216974892 1777 622330 SGTC_1591 genipin 88.4 µM 0.259911226651761 0.408806779807744 no 1341 0.39746612559737 1920 442424 A DNA cross-linking agent. SGTC_1381 2324-0066 62.1 µM 0.258465584635071 0.409331676775834 no 1342 0.398023803117741 1864 10885928 SGTC_807 1315-0151 48 µM 0.258143754424913 0.409448552001999 no 1343 0.398147982222966 1986 4011080 SGTC_1970 st070122 35.8 µM 0.256943051940132 0.409884667703085 no 1344 0.398611367656183 1928 102928 SGTC_500 h-89 112 µM 0.253806517045046 0.411024435665612 no 1345 0.399822519201422 1977 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_675 1309-0189 238 µM 0.2523392518554 0.411557875611709 no 1346 0.400389425466229 1838 4246530 SGTC_975 1335-0046 28.5 µM 0.251742444419021 0.411774898175007 no 1347 0.400620073680442 1773 16486740 SGTC_611 3453-1652 23.7 µM 0.251078782964157 0.412016263171228 no 1348 0.400876599664945 1964 1560575 SGTC_3136 9095672 49.47 µM 0.250471023112461 0.412237326687937 no 1349 0.401111555426931 2020 17217380 SGTC_323 4013-0906 34.3 µM 0.249844835997662 0.41246512197245 no 1350 0.401353672453101 1994 2910086 SGTC_2843 9000894 45.46 µM 0.249777315173862 0.412489686561288 no 1351 0.40137978183556 1866 2242070 SGTC_1946 st076057 65.1 µM 0.248806549909885 0.412842896187178 no 1352 0.401755212155737 1860 953009 SGTC_3158 9100007 49.47 µM 0.248657397741132 0.412897170956254 no 1353 0.401812902782938 1810 19297233 SGTC_2156 5649887 115 µM 0.248230776830713 0.413052422617556 no 1354 0.401977927464629 1963 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2937 9044753 11.33 µM 0.245803799708916 0.413935882159214 no 1355 0.402917057774878 1870 6465530 YGL099W LSG1 SGTC_1308 1187-1617 41.4 µM 0.245361350070992 0.414096988186949 no 1356 0.403088326309723 1850 2882570 SGTC_2531 methyl deoxycholate 70.07 µM 0.244226533880889 0.414510266733487 no 1357 0.403527689045413 1838 16667744 Haematoxylin. SGTC_2451 5856223 45.7 µM 0.243900547719957 0.414629002235593 no 1358 0.403653922484751 1831 2179896 SGTC_2638 epoxomicin 18 µM 0.243572645859174 0.414748443371832 no 1359 0.403780907876845 1982 9915668 A protesome inhibitor. SGTC_457 grayanotoxin iii 135 µM 0.241597152664354 0.415468200547277 no 1360 0.404546164292968 1920 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3056 9094900 49.47 µM 0.241452016591482 0.415521091081245 no 1361 0.404602400800119 1791 25236784 SGTC_169 k015-0017 16.025 µM 0.241428533497241 0.415529648941826 no 1362 0.404611500082324 1963 1840002 SGTC_2450 5739737 12.93 µM 0.239563508784314 0.416209440893707 no 1363 0.405334328406756 1882 2262825 SGTC_879 0831-1030 162 µM 0.237785076153607 0.41685790406088 no 1364 0.406023897116906 1842 1549252 SGTC_780 0109-0199 192 µM 0.237683610331784 0.416894907999915 no 1365 0.406063248246012 2013 610414 SGTC_1835 st008666 49.2 µM 0.237098199158712 0.417108418095468 no 1366 0.406290304702326 1834 690455 SGTC_2041 5107442 45.335 µM 0.236721737677498 0.417245733360518 no 1367 0.406436334986949 1987 793005 SGTC_2149 5554786 194.827 µM 0.23642328316176 0.41735460256442 no 1368 0.406552115437732 1872 745063 YPR165W RHO1 SGTC_2444 5485484 36.41 µM 0.235241917765505 0.417785599039223 no 1369 0.407010486514863 1952 6790631 SGTC_797 k781-0471 270 µM 0.234722294749035 0.417975203944008 no 1370 0.40721214119724 1941 23738129 SGTC_1409 3909-8004 61.9 µM 0.234471683877445 0.418066656000092 no 1371 0.407309406761587 1898 2119279 SGTC_1550 gossypolone 36.6 µM 0.234459139358791 0.418071233819102 no 1372 0.407314275613983 1982 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3317 9138495 8.753 µM 0.233612223887286 0.418380320799028 no 1373 0.407643018512098 1918 17020139 SGTC_684 1140-0066 328 µM 0.233145186783902 0.4185507904206 no 1374 0.40782433378462 1870 6813534 SGTC_230 MPP+ 141.667 µM 0.232850479027843 0.418658367306537 no 1375 0.407938756735246 1827 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_664 1222-0054 14.9 µM 0.230993268731177 0.419336442626615 no 1376 0.408660015704415 1887 6813991 SGTC_2107 5363541 170.161 µM 0.230723382253677 0.419434999307694 no 1377 0.408764853578189 1961 244052 SGTC_197 4544-0043 41.561 µM 0.229889747382331 0.419739456553049 no 1378 0.409088721694606 1966 896523 SGTC_3097 9117246 49.47 µM 0.228654213719131 0.420190782211003 no 1379 0.40956884207151 1883 16423892 SGTC_2321 7390090 138.78 µM 0.228633148880544 0.420198477856087 no 1380 0.409577028909431 1823 649046 SGTC_1832 st054113 55 µM 0.228127642009407 0.420383164487865 no 1381 0.409773505695115 2028 1251267 SGTC_2180 6301957 200 µM 0.226732148658746 0.420893098016692 no 1382 0.410316013514718 2004 845462 SGTC_3045 9092950 49.47 µM 0.223976582819059 0.421900410876815 no 1383 0.411387762285292 2044 44120432 SGTC_733 4069-0007 56.1 µM 0.223934627060367 0.421915752011928 no 1384 0.411404085676276 1946 5717425 YNL287W SEC21 SGTC_308 4092-1169 104 µM 0.223475291400615 0.422083715971723 no 1385 0.41158280574712 1946 2268590 YDL196W YDL196W SGTC_2623 humulene 100 µM 0.223120965448471 0.422213291016045 no 1386 0.411720680776822 1869 6187145 An anti-inflammatory. SGTC_1861 st057647 17.4 µM 0.222646032794874 0.422386984469137 no 1387 0.411905503283811 2022 688668 SGTC_2659 sanguinarine 24.21 µM 0.221970473202356 0.422634077661286 no 1388 0.412168434468408 1920 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3186 9110464 49.47 µM 0.221768972494781 0.422707784613028 no 1389 0.41224686719499 1990 17018021 SGTC_680 0417-1641 114 µM 0.220915061859102 0.423020166620888 no 1390 0.41257928473849 1874 2835990 SGTC_3148 9097893 49.47 µM 0.219976272261719 0.423363655345762 no 1391 0.412944817046376 1819 17174100 SGTC_1935 st074532 41.6 µM 0.219220832522385 0.423640101478783 no 1392 0.413239014071968 2053 2829742 SGTC_2166 5933061 31.504 µM 0.218596956078523 0.42386843159499 no 1393 0.413482012078925 2000 2877375 SGTC_660 4031-1742 102 µM 0.218349966269859 0.423958833502797 no 1394 0.413578223032437 1896 6738706 SGTC_2332 7982454 138.89 µM 0.215042200635865 0.425169908253254 no 1395 0.414867208387507 2012 2981748 SGTC_2976 9009005 19.48 µM 0.214025978908863 0.425542120687595 no 1396 0.415263399153465 2059 2993148 SGTC_1232 0279-0259 161 µM 0.213920971431203 0.425580585658371 no 1397 0.415304342966201 1860 1560000 SGTC_1797 st048695 56.8 µM 0.213639792733467 0.425683586861061 no 1398 0.415413982809257 2029 592262 YIL048W NEO1 SGTC_804 1595-0054 20.9 µM 0.210174078347285 0.426953559518861 no 1399 0.416765905098486 1914 761523 Stimulates phospholipase C. SGTC_382 3229-0966 23.2 µM 0.208688323236939 0.427498230785436 no 1400 0.417345778078008 2024 5722370 SGTC_1329 1447-1697 50.6 µM 0.207695992332498 0.427862091965747 no 1401 0.417733173550869 1952 2840515 SGTC_3127 9126946 49.47 µM 0.2070195485969 0.428110160962626 no 1402 0.417997295810436 1862 27243249 SGTC_393 acivicin 6.25 µM 0.206227752119634 0.428400568811417 no 1403 0.418306505347633 1939 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1837 st055472 66.5 µM 0.204641058018104 0.428982638478565 no 1404 0.418926287263907 1981 676091 SGTC_1643 st009866 20.2 µM 0.2044098646623 0.429067463364378 no 1405 0.419016611022306 2035 3156273 YOR207C RET1 SGTC_269 exalamide 29 µM 0.204163816902909 0.42915774193199 no 1406 0.419112742860963 1956 3316 A derivative of salicylamide. SGTC_2048 5246248 200 µM 0.203190077405053 0.429515057685951 no 1407 0.419493234076878 2061 677046 SGTC_1671 st016596 74.5 µM 0.202141489662682 0.429899903735471 no 1408 0.419903056619654 1963 2829167 SGTC_429 1112-0049 25.5 µM 0.201619994543625 0.430091324405517 no 1409 0.420106906420821 1865 2836170 SGTC_2854 9024559 71.43 µM 0.201062752918137 0.430295884393845 no 1410 0.42032475303792 1889 3163529 SGTC_2964 9083345 53.42 µM 0.200642898862709 0.430450022607868 no 1411 0.420488905836829 1906 17741579 SGTC_3331 9141060 1.957 µM 0.200216676616749 0.430606509573073 no 1412 0.420655562589495 1897 4906567 YPR165W RHO1 SGTC_2493 resveratrol 26.09 µM 0.198914035979274 0.431084839901831 no 1413 0.421164994893343 1936 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1460 k062-0059 9.15 µM 0.198320297108691 0.431302894712813 no 1414 0.421397236136861 1904 1373085 SGTC_1645 Cervolide 78 µM 0.196787015167059 0.431866100077892 no 1415 0.42199710641339 1949 23173 A fragrance. SGTC_1319 1306-0155 43.7 µM 0.193724665158622 0.432991376453775 no 1416 0.42319573884576 1984 3122360 SGTC_3064 1327-0027 10 µM 0.193011994966307 0.433253329110618 no 1417 0.42347478704971 1981 16000455 YPR107C YTH1 SGTC_1316 1272-0050 65.9 µM 0.192466492658316 0.43345385651696 no 1418 0.423688406098542 1973 7340392 SGTC_851 0394-0702 453 µM 0.192384083602476 0.433484151691217 no 1419 0.423720679488572 2086 762646 SGTC_2280 7785178 200 µM 0.19137670509574 0.433854515189994 no 1420 0.424115234699008 1959 2954328 SGTC_99 0109-0120 622.8 µM 0.191074648876789 0.433965577729051 no 1421 0.42423355448254 2053 759414 SGTC_2805 7950783 58.44 µM 0.190240873552602 0.434272174194374 no 1422 0.424560191729473 1981 1178958 YDL195W SEC31 SGTC_835 0312-0010 67.2 µM 0.189256787263182 0.434634093978541 no 1423 0.424945780987403 1951 1626196 SGTC_2868 9035608 32.47 µM 0.188990517094352 0.434732030229297 no 1424 0.425050124561534 1993 6462614 SGTC_1335 1486-0900 202 µM 0.188990160494768 0.4347321613921 no 1425 0.425050264306115 2054 X1335 SGTC_1809 st050081 57.6 µM 0.188846149979841 0.434785131257947 no 1426 0.425106700051914 2040 5036894 SGTC_1727 st034309 9.9045 µM 0.188218210526991 0.435016113258776 no 1427 0.425352798834022 2083 870305 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.187761219607433 0.435184227294279 no 1428 0.425531918644271 1963 5379071 SGTC_3301 9125354 19.7965 µM 0.182079877569439 0.437275201135854 no 1429 0.427760020065792 1939 41905162 SGTC_259 usnic acid 108.925 µM 0.181802700793715 0.437377259223213 no 1430 0.427868782459596 2049 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_971 1315-0384 26.7 µM 0.181368684100083 0.437537075041115 no 1431 0.428039098841139 1917 6769120 SGTC_673 1082-0474 110 µM 0.18112672517128 0.437626174805342 no 1432 0.428134053936105 1971 3098046 SGTC_341 1486-1430 230 µM 0.176707047348272 0.439254243773007 no 1433 0.42986925250463 1962 2054753 YPL210C SRP72 SGTC_133 0724-0033 378.92 µM 0.176451372526542 0.439348457980184 no 1434 0.42996967414895 2112 280309 SGTC_2571 chrysanthemic acid 100 µM 0.176385982154877 0.439372554381599 no 1435 0.429995358315568 1902 2743 An insecticide. SGTC_1984 st072354 53.1 µM 0.172928569549464 0.440646931321639 no 1436 0.431353787348638 2004 5762938 SGTC_2301 7769476 200 µM 0.172657982109375 0.44074669398683 no 1437 0.431460136547158 2019 977820 SGTC_532 1548-0774 215 µM 0.171746325219065 0.441082839674932 no 1438 0.43181848231235 2109 5932993 SGTC_27 0485-0001 32.618 µM 0.171522925264839 0.441165218083145 no 1439 0.431906302897153 2106 2054479 SGTC_2382 9035899 200 µM 0.170421336122785 0.441571464634529 no 1440 0.43233939688819 1965 6462679 SGTC_136 0097-0015 404.482 µM 0.169977644479335 0.441735107639384 no 1441 0.432513858957473 2136 4861337 SGTC_1515 3460-0031 42.1 µM 0.167204739528492 0.442758038734166 no 1442 0.433604477657496 2050 2876596 SGTC_1898 st060199 18.6 µM 0.166335492986798 0.443078784711902 no 1443 0.433946467861277 1946 688866 SGTC_3107 9121808 49.47 µM 0.164919349349464 0.443601411745701 no 1444 0.434503731179624 2131 662681 SGTC_1488 4013-0813 75.9 µM 0.164641404872495 0.443703998549164 no 1445 0.434613119765198 1997 2910057 SGTC_1256 0570-0116 285 µM 0.16327247304381 0.444209313879641 no 1446 0.43515195319068 1973 410638 SGTC_2588 indole-3-carbinol 100 µM 0.160866620054755 0.445097608367686 no 1447 0.436099226593692 2123 3712 Induces cell cycle arrest. SGTC_320 4092-0846 5.34 µM 0.16084186341344 0.445106750511828 no 1448 0.436108976115244 2108 1359356 SGTC_2951 9072950 58.06 µM 0.159083322551106 0.445756219713358 no 1449 0.436801613781503 2152 16488155 SGTC_2601 securinine 100 µM 0.158945959845667 0.445806957042252 no 1450 0.436855725109308 1991 442872 A GABA receptor antagonist. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.158644685425898 0.445918241149684 no 1451 0.436974410359048 2034 689007 SGTC_1987 st072290 61.9 µM 0.158583729745538 0.445940757348358 no 1452 0.436998424173859 2017 54697379 SGTC_1336 1486-0901 104 µM 0.156242581206851 0.446805677009929 no 1453 0.437920906954487 2042 5006114 SGTC_816 0325-0417 81.3 µM 0.155437872665186 0.447103029164651 no 1454 0.438238064457089 2007 68101 SGTC_551 k048-0028 34.9 µM 0.153613882262561 0.447777131445952 no 1455 0.438957095201654 2110 6836383 SGTC_1502 4534-4282 27.7 µM 0.153433335931906 0.44784386519484 no 1456 0.439028278921652 2034 3278949 SGTC_18 0111-0177 500 nM 0.152458501365177 0.448204210160483 no 1457 0.439412659435167 2090 721752 SGTC_1903 st060211 78.3 µM 0.15138047609549 0.448602749048591 no 1458 0.439837794894688 2138 688960 SGTC_204 PMA1.184 62.41 µM 0.149314567994629 0.449366646374585 no 1459 0.440652710267905 2150 2252213 YGL008C PMA1 SGTC_190 3970-0790 3.722 µM 0.148825135627627 0.449547648186524 no 1460 0.440845808074717 2147 2832352 SGTC_932 2857-0803 154 µM 0.147770469563311 0.449937720284017 no 1461 0.441261957658251 2143 674898 SGTC_1674 st016616 23.6 µM 0.147563828410385 0.450014152948709 no 1462 0.44134350162954 1971 625830 SGTC_313 3474-0040 5.03 µM 0.14732042529716 0.450104185547259 no 1463 0.441439555659481 2051 1043375 YIL048W NEO1 SGTC_2606 farnesol 9.78 µM 0.147145877212578 0.450168750878137 no 1464 0.441508439590234 2141 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2560 caryophyllene 100 µM 0.146917490097149 0.45025323325647 no 1465 0.441598573312498 2174 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1676 st018489 23.4 µM 0.146886712708365 0.450264618252438 no 1466 0.441610719941016 1974 3696235 SGTC_1111 tnp00062 510.699 nM 0.146683898573934 0.450339643122379 no 1467 0.441690764099852 2157 676306 SGTC_1994 st072947 40.9 µM 0.146076165359163 0.450564466005427 no 1468 0.441930630928578 2064 5286565 YDL195W SEC31 SGTC_282 k297-0036 65.7 µM 0.146043146723024 0.450576681269142 no 1469 0.441943663697716 2114 5061378 SGTC_1067 clotrimazole 1.36 µM 0.145457035822699 0.450793521119316 no 1470 0.442175017680267 2030 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2092 5303694 80.6725 µM 0.145342504117608 0.450835895428267 no 1471 0.442220228779039 2022 1963699 SGTC_2822 7994718 71.43 µM 0.145210185565771 0.450884851191995 no 1472 0.442272462127207 2148 1018011 SGTC_2566 crystal violet carbinol 226 nM 0.14511207263687 0.450921151900673 no 1473 0.442311193298696 1888 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2489 cantharidin 73.42 µM 0.144602892333187 0.451109549620505 no 1474 0.442512206743649 2144 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_843 0310-0051 143 µM 0.144555215918872 0.451127190552713 no 1475 0.442531029126372 2041 2065037 SGTC_2103 5378138 10 µM 0.144334223261599 0.451208962150297 no 1476 0.44261827748968 2124 244142 SGTC_1560 lithocholic acid 53.1 µM 0.143301145372638 0.451591248545501 no 1477 0.443026175646292 2164 9903 A bile acid which acts as a detergent. SGTC_1427 4048-4900 550 nM 0.14189630455345 0.452111176316772 no 1478 0.443580956660813 2163 24132586 SGTC_1184 1269-1718 139 µM 0.141280265663999 0.452339196596001 no 1479 0.443824269476743 2136 5403821 SGTC_902 1120-0002 2.07 µM 0.141083236081727 0.452412128333547 no 1480 0.443902093425084 2146 3280475 SGTC_2892 9047358 58.44 µM 0.140210134655033 0.45273533160021 no 1481 0.444246982354501 2045 6466771 SGTC_1545 lovastatin 49.4 µM 0.140130651413518 0.452764756135816 no 1482 0.444278381597926 2060 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1824 st053723 68.6 µM 0.140027721874945 0.452802860828697 no 1483 0.444319043640391 2010 675225 SGTC_978 1416-0512 87.4 µM 0.139458351286006 0.453013650646136 no 1484 0.444543982564331 2055 6814003 SGTC_1082 camptothecin 424.86 nM 0.139439474448775 0.453020639370968 no 1485 0.444551440465979 2034 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2954 9074818 52.69 µM 0.138700252784156 0.453294331003612 no 1486 0.444843509169049 2088 16648742 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.138112748640154 0.453511866119087 no 1487 0.445075655189595 2062 23665772 A membrane-active detergent. SGTC_976 1348-1067 47.6 µM 0.138015623909473 0.453547829831251 no 1488 0.445114034811624 2122 5310671 YGL099W LSG1 SGTC_97 0535-0701 19.132 µM 0.136805560137925 0.45399592866079 no 1489 0.445592244307562 2142 2832013 YGL099W LSG1 SGTC_1998 st075797 76.8 µM 0.136678890014793 0.454042839282062 no 1490 0.445642308122963 2182 24208315 SGTC_154 3389-1638 511.116 µM 0.136197725899953 0.454221037948365 no 1491 0.445832486442974 1911 5238686 SGTC_622 1348-1566 26.3 µM 0.135730563807506 0.454394059796369 no 1492 0.446017142441003 2114 7340407 SGTC_2691 st077356 60.2 µM 0.135688239780545 0.454409735685824 no 1493 0.446033872514095 2120 2839272 SGTC_1204 4049-0315 18.3 µM 0.135454750737462 0.454496216171886 no 1494 0.446126169067604 2132 588402 SGTC_2583 asiatic acid 100 µM 0.13538237646265 0.454523022846314 no 1495 0.446154778695156 2098 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2291 7917025 104.35 µM 0.13407689187341 0.455006596130571 no 1496 0.446670886126191 2055 2964612 SGTC_20 0481-0013 4.944 µM 0.133304093521577 0.455292885006076 no 1497 0.446976445166716 2070 182045 SGTC_974 1326-0144 138 µM 0.131914848266337 0.455807599495099 no 1498 0.447525822023762 2033 5411856 SGTC_1611 st001856 99.4 µM 0.131692328224965 0.455890049944511 no 1499 0.447613826928005 2004 647478 SGTC_969 1313-0238 134 µM 0.131268125248474 0.456047235320657 no 1500 0.447781602967742 2065 5212874 SGTC_3060 1327-0027 12.5 µM 0.131081900906859 0.45611624159159 no 1501 0.447855259299342 2176 16000455 YPR107C YTH1 SGTC_798 1287-0182 476 µM 0.130461214194352 0.456346249403174 no 1502 0.448100769210271 2181 1649755 SGTC_3168 9103419 49.47 µM 0.130287420390335 0.456410654780067 no 1503 0.448169516155078 2184 16649256 SGTC_1995 st072814 61.1 µM 0.129013939545206 0.456882622511558 no 1504 0.448673309424462 2015 5769371 SGTC_1512 0259-0544 12.2 µM 0.128754081693119 0.4569789365354 no 1505 0.448776120252512 2062 18476 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.12739807330291 0.4574815699736 no 1506 0.449312670548796 2073 279621 SGTC_581 0958-0271 211 µM 0.126466487944897 0.45782692142416 no 1507 0.449681337383842 2101 4591145 SGTC_345 1362-0200 395 µM 0.123916945875596 0.458772233648642 no 1508 0.450690517746819 2038 1419823 SGTC_1878 temozolomide 1 mM 0.123430029757847 0.458952797757258 no 1509 0.450883289286729 2206 5394 DNA alkylating agent. SGTC_192 3455-0609 60.9 µM 0.122507932524382 0.459294764151423 no 1510 0.451248382034223 2132 3769639 SGTC_2037 5169046 200 µM 0.12172979585133 0.459583365179722 no 1511 0.451556507517889 2116 5718022 SGTC_2164 5685496 200 µM 0.121092303498691 0.459819818891188 no 1512 0.451808962617535 2183 759046 SGTC_1672 st016598 6.51 µM 0.120763484701726 0.459941787366216 no 1513 0.45193918667873 2036 4665860 YNL267W PIK1 SGTC_3137 9097352 49.47 µM 0.118801791231706 0.460669514584665 no 1514 0.45271619476944 2151 44120435 SGTC_2472 5377652 49.4 µM 0.11825402941504 0.46087274080342 no 1515 0.452933190477116 2044 1610903 SGTC_1468 k284-1086 134 µM 0.117822334367422 0.461032912059056 no 1516 0.4531042162705 2084 15996457 SGTC_406 estrone 100 µM 0.117352947452003 0.461207075252584 no 1517 0.45329018442357 2215 5870 A steroid. SGTC_1724 st037281 8.293 µM 0.116819339000113 0.461405076496664 no 1518 0.453501609186945 2130 574124 YDL195W SEC31 SGTC_1269 0831-0796 3.05 µM 0.116332485857607 0.461585737020276 no 1519 0.453694520199465 2190 927758 SGTC_711 k292-0785 179 µM 0.115772570062751 0.461793519290206 no 1520 0.453916395111858 2168 4146315 SGTC_2608 thymoquinone 42.66 µM 0.115029640771278 0.462069233146575 no 1521 0.454210814019898 2221 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2572 astragaloside iv 100 µM 0.114689238365951 0.462195568439625 no 1522 0.45434572208935 2090 45006101 An anti-inflammatory agent. SGTC_2617 dihydrotanshinone i 20.83 µM 0.114496693186047 0.462267030410861 no 1523 0.454422033808409 2138 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1394 3474-0001 65.7 µM 0.114487723836174 0.462270359360167 no 1524 0.454425588685288 2119 5017666 YIL048W NEO1 SGTC_1038 k292-0204 154 µM 0.114244892429471 0.462360486566225 no 1525 0.454521832917002 2189 4454212 SGTC_1371 2421-0008 32.7 µM 0.114090303698049 0.46241786339066 no 1526 0.454583104281117 2092 2827552 SGTC_2275 7947463 200 µM 0.112496389900875 0.463009502427122 no 1527 0.45521491600809 2211 1225414 SGTC_2117 5521686 200 µM 0.112217264428527 0.463113118448072 no 1528 0.455325570298205 2123 803312 SGTC_2641 levomentholum 100 µM 0.111580605512404 0.463349466186946 no 1529 0.45557797526859 2197 16666 SGTC_2600 tangeritin 87.95 µM 0.111046285325793 0.463547832571061 no 1530 0.455789821645154 2161 68077 A bioactive flavone. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.110890786346169 0.463605563276341 no 1531 0.455851475985338 2136 5393153 SGTC_854 0422-0053 192 µM 0.109951881438203 0.463954158283947 no 1532 0.45622376824856 2189 3596728 SGTC_1 0258-0098 57.368 µM 0.109460366994742 0.46413665797822 no 1533 0.456418677693476 2105 6790032 YDR047W HEM12 SGTC_2511 berberine 10.47 µM 0.109176667116684 0.46424199940031 no 1534 0.456531183305649 2131 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2062 5245942 200 µM 0.109138598219981 0.464256135063337 no 1535 0.456546280385859 2218 1376160 SGTC_2921 7974240 10.71 µM 0.107759896983202 0.464768101784825 no 1536 0.457093077578739 2158 2979074 YDR527W RBA50 SGTC_1699 st031318 29.054 µM 0.107282918942023 0.46494523636708 no 1537 0.457282267519013 2174 5340658 SGTC_477 mead ethanolamide 10 µM 0.10726223099314 0.464952919375442 no 1538 0.457290473465849 2217 16061185 SGTC_3078 9116413 49.47 µM 0.103774824179142 0.466248243146749 no 1539 0.458674022985521 2201 17177322 SGTC_2372 9071633 200 µM 0.102881188099626 0.466580223543794 no 1540 0.459028634093261 2253 21321366 SGTC_2765 myclobutanil 7.74 µM 0.102609648790958 0.466681103370972 no 1541 0.45913639231883 2120 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2949 9072542 2.23 µM 0.102071186563195 0.466881154310582 no 1542 0.459350085664887 2134 16457352 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0996037069385587 0.467797985245197 no 1543 0.460329475376215 2159 2724278 An inhibitor of dopamine biosynthesis. SGTC_3260 9137109 49.47 µM 0.0992236631340486 0.467939211814168 no 1544 0.460480343551107 2230 17478346 SGTC_2140 5586273 200 µM 0.0984518766888954 0.46822602470971 no 1545 0.460786741540602 2234 854421 SGTC_1758 st042942 75.2445 µM 0.0980722334216253 0.468367114597266 no 1546 0.460937467867319 2223 669317 SGTC_3204 9114183 49.47 µM 0.0979100575928047 0.468427386519959 no 1547 0.461001856779241 2153 17027248 SGTC_279 1273-0055 2.93 µM 0.0975109694815707 0.468575708913385 no 1548 0.461160311679308 2227 2847562 SGTC_841 0251-0215 91.2 µM 0.0965596944628119 0.468929270917045 no 1549 0.461538033013034 2167 3888614 SGTC_3098 9119039 49.47 µM 0.0955259444077848 0.46931351433236 no 1550 0.461948541913498 2261 17161528 SGTC_2832 7992762 51.95 µM 0.0940142260020664 0.469875469259892 no 1551 0.462548928037175 2033 2985177 SGTC_919 tnp00227 403.569 nM 0.0937136212138608 0.46998722103039 no 1552 0.462668324867153 2155 1269246 A methoxyflavone. YNL221C POP1 SGTC_822 1487-0950 154 µM 0.0934553615368201 0.470083232620728 no 1553 0.462770905383385 2266 1958375 SGTC_2982 9019404 25.97 µM 0.0923106856349444 0.470508802508217 no 1554 0.463225599356192 2025 22333232 SGTC_636 0kpi-0074 126 µM 0.0916650974178268 0.470748835469226 no 1555 0.463482064414193 2146 616434 SGTC_1245 0418-0076 17.2 µM 0.091110275039401 0.47095512972759 no 1556 0.463702484150982 2157 6790114 SGTC_2841 9004761 38.96 µM 0.0903017230606728 0.47125577975913 no 1557 0.464023725471475 2091 2991039 SGTC_646 4092-0839 27.3 µM 0.0894822701860381 0.471560499868283 no 1558 0.464349321698084 2220 877796 SGTC_2671 danthron 100 µM 0.0891746146840164 0.471674908337165 no 1559 0.464471569767316 2176 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_917 harmaline 728.087 nM 0.088326056427068 0.471990475484632 no 1560 0.464808764925475 2198 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1684 st024538 14.6195 µM 0.0879023425134909 0.472148055457423 no 1561 0.46497714737858 2162 6732859 SGTC_986 1493-0483 84 µM 0.0874874980773733 0.472302341079455 no 1562 0.465142011208075 2253 40079 SGTC_759 3486-0358 89.3 µM 0.0874872571239828 0.472302430694122 no 1563 0.465142106967395 2271 875103 SGTC_2887 9044784 58.44 µM 0.086874276230018 0.472530413246011 no 1564 0.465385723396272 2279 6465546 SGTC_485 niflumic acid 177 µM 0.0867874233820348 0.472562716669123 no 1565 0.465420242294624 2227 4488 A COX2 inhibitor. SGTC_1900 st060200 72.8 µM 0.0867638246640077 0.47257149383763 no 1566 0.465429621441917 2221 688945 SGTC_2098 5376439 882.5 nM 0.0866275613370253 0.472622175079078 no 1567 0.46548377873438 2210 2844116 SGTC_3264 9137442 49.47 µM 0.0865346289316034 0.472656740243682 no 1568 0.465520714699058 2259 17015726 SGTC_1919 st067113 52.3 µM 0.0857253481140818 0.472957751831632 no 1569 0.4658423757087 2174 1268243 SGTC_3233 9132340 49.47 µM 0.0845252497795356 0.473404156176339 no 1570 0.466319414125893 2209 17682950 SGTC_198 3454-2873 16.191 µM 0.0841048150933474 0.473560554515651 no 1571 0.466486548160062 2180 710957 SGTC_3067 9117431 49.47 µM 0.0840145005656282 0.47359415132993 no 1572 0.466522451372833 2163 17150885 SGTC_1045 1348-1485 165 µM 0.0840122907982173 0.473594973361113 no 1573 0.466523329836797 2258 6810614 SGTC_258 haloperidol 50.781 µM 0.0831971348991278 0.473898218150826 no 1574 0.4668473954313 2109 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2513 baicalein 25.65 µM 0.0823598108849773 0.474209725410212 no 1575 0.467180296851013 2176 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_903 1134-0042 114 µM 0.082192180770981 0.47427209026288 no 1576 0.467246945624595 2164 701009 SGTC_2876 9059903 25.97 µM 0.0803800127095564 0.474946326443609 no 1577 0.467967511504434 2256 6916095 SGTC_2790 5423970 71.43 µM 0.0802221763637924 0.475005054540451 no 1578 0.468030276407119 2241 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2725 haloperidol 53.21 µM 0.0795590092493617 0.475251813147788 no 1579 0.468293998853746 2263 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3218 9131285 49.47 µM 0.078910148037915 0.475493257844001 no 1580 0.468552045723496 2246 17156417 SGTC_2627 acetyl isogambogic acid 100 µM 0.078092645503936 0.475797467671078 no 1581 0.468877178683674 2177 6857789 A caspase activator and apoptosis inducer. SGTC_1285 0929-0069 65.5 µM 0.0780217674312516 0.475823843554633 no 1582 0.468905368932097 2190 1206237 SGTC_695 3505-6186 243 µM 0.0762515545529234 0.476482627595924 no 1583 0.469609483719635 2223 1819379 SGTC_343 4130-2827 29.8 µM 0.0749791604102351 0.476956188399597 no 1584 0.470115646397354 2167 1118244 SGTC_2865 9030313 51.95 µM 0.0745763990856821 0.477106095286877 no 1585 0.470275876310608 2249 42562754 SGTC_2924 9010168 62.78 µM 0.0735309501603569 0.477495224164786 no 1586 0.470691808031327 2195 2993929 SGTC_216 k038-0035 28.382 µM 0.0721228888340956 0.478019355658767 no 1587 0.471252055500792 2266 4444231 YPR107C YTH1 SGTC_1925 st057770 10.1 µM 0.0707492182307156 0.478530722323922 no 1588 0.471798674232394 2152 5989122 SGTC_2003 4023581 200 µM 0.0699554544776365 0.478826227323583 no 1589 0.472114557453501 2210 16641307 SGTC_294 k038-0071 157 µM 0.0689047817682745 0.479217393113983 no 1590 0.472532706133877 2214 24152826 SGTC_2025 5147754 141 µM 0.0686774907418718 0.479302016283321 no 1591 0.472623167838284 2272 315777 YLR208W SEC13 SGTC_1018 4259-0013 28.1 µM 0.0686248094817685 0.479321630280266 no 1592 0.472644135152788 2212 6801262 SGTC_3050 9093513 49.47 µM 0.0686105484963746 0.479326939860508 no 1593 0.472649811084842 2267 25236664 SGTC_2023 5144124 124 µM 0.0684271412910396 0.47939522545964 no 1594 0.47272280841709 2245 2830192 SGTC_661 1304-0007 33.6 µM 0.0676879398625684 0.479670448741965 no 1595 0.473017024944043 2228 3117130 SGTC_2429 5902844 64.44 µM 0.0671568069598746 0.479868208871197 no 1596 0.473228435254468 2273 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_824 1304-0008 100 µM 0.067152723650337 0.479869729255353 no 1597 0.473230060590212 2234 768245 SGTC_766 1391-0721 126 µM 0.0666724128119274 0.480048570781137 no 1598 0.473421248408302 2281 1020919 YIL115C NUP159 SGTC_236 1509-0011 5.31 µM 0.0662166419131166 0.480218278687874 no 1599 0.473602673760952 2271 3107280 SGTC_1610 st001799 48.1 µM 0.0637557303739055 0.481134668976914 no 1600 0.474582364273255 2231 621897 SGTC_748 act1.228 77.9 µM 0.0635110957785347 0.481225771142395 no 1601 0.474679761964688 2255 4421505 YNR035C ARC35 SGTC_1705 st027868 56.3335 µM 0.0634009443971672 0.481266791946278 no 1602 0.474723617622939 2291 292948 SGTC_26 0302-0163 425.158 µM 0.0620889598851781 0.481755395223559 no 1603 0.475245994385763 2248 3100915 SGTC_2007 4011539 71.82 µM 0.0614324635149219 0.481999894936015 no 1604 0.475507399514418 2268 45595301 SGTC_1281 0884-0031 11.8 µM 0.0611714226685194 0.482097116570721 no 1605 0.475611344252628 2285 1548255 SGTC_2926 9010726 65.15 µM 0.0610619484576833 0.482137889287659 no 1606 0.475654936653608 2231 2994293 SGTC_117 lucigenin 22.078 µM 0.0610319673431992 0.482149055525393 no 1607 0.475666875121321 2106 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2200 6600604 21.907 µM 0.0609918439756344 0.482163999189946 no 1608 0.475682852264303 2281 2904777 SGTC_821 1114-0266 29.2 µM 0.0605752343414773 0.48231916397957 no 1609 0.475848748713636 2237 3123235 SGTC_1444 4112-3581 28 µM 0.0596069490447213 0.482679808731065 no 1610 0.476234341837443 2271 2877249 SGTC_1887 st057648 70.8 µM 0.0595005021271035 0.482719456513279 no 1611 0.476276732773959 2300 688672 SGTC_3271 9137798 49.47 µM 0.0571729634649005 0.483586425919753 no 1612 0.477203707475669 2297 6498326 SGTC_3185 9108267 49.47 µM 0.0558547054429174 0.484077489777416 no 1613 0.477728777142018 2218 4910486 SGTC_817 1391-0715 46 µM 0.0547149840304835 0.484502066515944 no 1614 0.47818276585764 2252 1353946 SGTC_1854 st056233 32.9 µM 0.0545285594911012 0.484571516332745 no 1615 0.478257027624325 2315 5393174 SGTC_610 4215-0184 155 µM 0.0541763415316614 0.484702731411383 no 1616 0.478397334859365 2263 5605015 SGTC_2393 9031399 185.94 µM 0.0536415377178574 0.484901970083001 no 1617 0.478610380910425 2286 1526623 YDL150W RPC53 SGTC_1478 0453-0656 35.7 µM 0.0533540764007641 0.48500906401943 no 1618 0.478724897392126 2305 5258496 SGTC_1564 D-Arginine 115 µM 0.0527980755909462 0.485216205613481 no 1619 0.478946397409913 2242 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2726 cimetidine 79.27 µM 0.0509070705916283 0.485920740926719 no 1620 0.479699785649937 2319 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1317 1273-0028 910 nM 0.0507204462703344 0.485990274321999 no 1621 0.479774141924787 2294 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_138 0850-0259 40.9225 µM 0.0490930023457634 0.486596653099682 no 1622 0.480422590002074 2327 6813004 SGTC_2328 6201408 200 µM 0.0488022269846724 0.486704998082748 no 1623 0.480538453707008 2270 2890418 SGTC_516 3992-2719 87.3 µM 0.0478773418270089 0.487049623405836 no 1624 0.480906998640273 2305 5350887 YDR037W KRS1 SGTC_1051 3253-3903 78 µM 0.0471223089849361 0.487330966529634 no 1625 0.481207873543398 2323 5509239 SGTC_663 1486-0733 13.9 µM 0.0463043074722916 0.487635780383312 no 1626 0.481533853063687 2282 722445 YPR165W RHO1 SGTC_2480 5767542 37.17 µM 0.045908762723738 0.487783175767594 no 1627 0.481691484949651 2302 2867358 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0448298608260428 0.488185225074722 no 1628 0.482121461757776 2334 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1430 4049-0248 69.1 µM 0.043286007384021 0.488760557854323 no 1629 0.482736772629153 2316 22774488 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.042925022904537 0.488895085831513 no 1630 0.482880650868665 2312 6708514 SGTC_3188 9110789 49.47 µM 0.0427058619263171 0.488976761104571 no 1631 0.482968003346586 2315 849217 SGTC_1992 st073643 23.3 µM 0.0425481593009375 0.489035532824871 no 1632 0.48303086045793 2333 3161292 SGTC_2344 7990960 76.95 µM 0.0422755489678642 0.489137128258944 no 1633 0.483139518476431 2280 140813 SGTC_1310 1188-0297 994 nM 0.0421322426294787 0.489190535430479 no 1634 0.483196638540916 2286 1588352 SGTC_1867 st057372 64 µM 0.0419537856786039 0.48925704274557 no 1635 0.483267769669741 2331 688837 SGTC_3277 9138724 49.47 µM 0.0412354883283354 0.489524740718137 no 1636 0.483554081063706 2218 15943418 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0410239946225179 0.489603561955685 no 1637 0.48363838350932 2270 676296 Flavone; oxidizing agent. SGTC_1799 st045822 46.1415 µM 0.0397051786793723 0.490095078315309 no 1638 0.484164086472671 2338 3674992 SGTC_2736 butenafine 14.65 µM 0.0394831748082938 0.490177819589902 no 1639 0.484252583807296 2304 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2246 7293507 91.5585 µM 0.0390331438852633 0.490345548283436 no 1640 0.484431981870766 2331 887656 SGTC_3343 9148379 18.9835 µM 0.0381811246370394 0.490663104614442 no 1641 0.484771635139551 2343 1955036 SGTC_995 3931-2021 34.6 µM 0.0376359520180687 0.49086629917051 no 1642 0.484988971326294 2283 730143 SGTC_1680 diphenhydramine 100 µM 0.0374890256558575 0.49092106138373 no 1643 0.485047545127578 2228 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1474 0330-0125 5.35 µM 0.0370438845657674 0.491086974864341 no 1644 0.485225007456064 2341 X1474 SGTC_399 oxolinic acid 75 µM 0.0354843112893751 0.491668272722087 no 1645 0.485846778137399 2278 4628 A DNA gyrase inhibitor. SGTC_2416 tofa 880 nM 0.0339545000254943 0.492238494620352 no 1646 0.486456716740027 2254 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2650 prasterone 100 µM 0.0338431724370968 0.492279991502307 no 1647 0.486501104510979 2337 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1108 betulinic acid 729.144 nM 0.0335414894259907 0.492392442971799 no 1648 0.486621390326938 2336 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1079 idarubicin 2.36 µM 0.0332475279891754 0.492502016828467 no 1649 0.48673859859931 2354 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3229 9132204 49.47 µM 0.032898148553907 0.492632248428508 no 1650 0.486877904619054 2328 17682924 SGTC_180 1486-1293 102.781 µM 0.030265955557091 0.493613425772732 no 1651 0.487927473828458 2358 4140536 SGTC_1704 st028805 70.8 µM 0.0295335882961345 0.493886430419211 no 1652 0.488219515515828 2309 2876101 SGTC_1821 st053465 65.6 µM 0.0275204777642258 0.494636872283423 no 1653 0.489022303569067 2325 675086 SGTC_1850 st056238 17 µM 0.0275189050963536 0.494637458546037 no 1654 0.489022930735243 2347 5393177 SGTC_765 1319-0117 244 µM 0.0272536124663858 0.494736355085155 no 1655 0.489128727500099 2362 3487746 YGL099W LSG1 SGTC_1826 st055655 41.6 µM 0.0264615030229021 0.495031641791405 no 1656 0.489444619488075 2264 676168 SGTC_2035 5154463 94.595 µM 0.0256025722786453 0.495351841563342 no 1657 0.489787167181072 2349 2769623 SGTC_2070 5230947 200 µM 0.0255958002020506 0.495354366129901 no 1658 0.489789867963671 2363 2835538 SGTC_2278 7948257 134.34 µM 0.0247400587925554 0.495673379954477 no 1659 0.490131151276844 2373 1247028 SGTC_146 3448-8650 53.125 µM 0.0246552440373307 0.49570499839781 no 1660 0.49016497715067 2294 2891488 YIL048W NEO1 SGTC_2711 st079103 59.1 µM 0.0237028015175015 0.496060065189616 no 1661 0.490544835673477 2345 54693780 SGTC_2728 chlorpromazine 9.18 µM 0.0236146706524662 0.496092920188438 no 1662 0.490579984963202 2374 2726 A thorazine and dopamine antagonist. SGTC_3104 9120930 49.47 µM 0.0221131286249867 0.496652695748024 no 1663 0.491178856954525 2289 17014836 SGTC_2059 5238311 157 µM 0.020308555044169 0.497325450232194 no 1664 0.491898615628511 2360 703021 SGTC_3021 9087658 49.47 µM 0.0197324207331406 0.49754023781466 no 1665 0.492128413902712 2371 25237042 SGTC_2920 7982904 15.77 µM 0.019266943080419 0.497713772213683 no 1666 0.492314077315829 2353 6456808 SGTC_929 2805-0021 398 µM 0.0185225914558156 0.497991274309002 no 1667 0.492610977640262 2265 3098024 SGTC_2466 5983409 37.09 µM 0.0181886268403127 0.498115780145471 no 1668 0.492744187801892 2275 2879657 SGTC_205 1486-1330 71.903 µM 0.0166026514105616 0.498707052262078 no 1669 0.49337680466542 2362 4118834 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0155426497297331 0.499102236237806 no 1670 0.493799629515687 2363 165506 SGTC_2253 7938677 135.83 µM 0.0154061709583148 0.499153117572237 no 1671 0.493854070149445 2370 2301972 SGTC_1693 xanthone 101.9 µM 0.0146090658264535 0.499450290577873 no 1672 0.49417203327084 2346 7020 An insecticide. SGTC_1562 morin hydrate 59.1 µM 0.0143301012995096 0.499554292908038 no 1673 0.494283312365212 2366 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1804 st050076 49.1 µM 0.0140966699030443 0.499641319799982 no 1674 0.494376428612461 2371 3895976 SGTC_717 1532-0246 73.2 µM 0.0137349376925883 0.49977617928328 no 1675 0.494520724912472 2373 9561992 SGTC_1993 st073995 70.8 µM 0.0136096473443616 0.499822889511388 no 1676 0.494570703858133 2325 3098394 SGTC_281 1672-3440 14.9 µM 0.0134670050567379 0.499876068820512 no 1677 0.494627604682782 2363 6833000 SGTC_776 4476-4378 112 µM 0.0128021665601802 0.499876068820512 no 1678 0.494892813986225 2284 2892008 SGTC_2091 4-phenylthiadiazole 200 µM 0.0121802420461903 0.499644205517789 no 1679 0.495140906610351 2380 270010 SGTC_2325 6158266 200 µM 0.0121449946087647 0.499631064718077 no 1680 0.495154967263386 2361 3623240 SGTC_396 dithiazanine 1.25 µM 0.0120227109576576 0.499585475450543 no 1681 0.495203747820398 2370 10578 An antihelmenthic. SGTC_2243 6634756 200 µM 0.0110470074632815 0.499221718092485 no 1682 0.49559297128747 2373 885676 SGTC_359 0081-0058 15.9 µM 0.0107179643976948 0.49909904587776 no 1683 0.495724232705037 2381 3494159 SGTC_2114 5491910 81.25 µM 0.01013236050566 0.498880724137806 no 1684 0.495957842158648 2383 2849228 SGTC_1443 4112-3303 14 µM 0.0100101087454512 0.498835146924487 no 1685 0.496006611081245 2390 704433 SGTC_1355 1499-0035 1.68 µM 0.00992521497843835 0.498803497316882 no 1686 0.49604047711183 2390 1548538 SGTC_474 dl-dihydrosphingosine 5 µM 0.00830687830330701 0.498200159983475 no 1687 0.496686073139199 2382 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1158 4092-0494 91.8 µM 0.00795285348393022 0.498068175345669 no 1688 0.49682730393984 2355 1148199 SGTC_1251 0490-5699 265 µM 0.00773473687808425 0.497986859000869 no 1689 0.496914317199005 2391 3883818 SGTC_1368 1852-0141 284 µM 0.00755488973177998 0.497919810007451 no 1690 0.496986063733001 2365 2838987 SGTC_432 NS 1619 61.3 µM 0.00613717020478376 0.49739127079047 no 1691 0.497551638692832 2342 4552 A K+/calcium channel activator. SGTC_2648 atorvastatin 78.68 µM 0.00607986086796418 0.497369905418996 no 1692 0.497574501383795 2390 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2312 7706453 155.7 µM 0.00568199598929183 0.497221578474552 no 1693 0.497733223759981 2394 976098 SGTC_1783 st039459 87.517 µM 0.00492442652248248 0.496939152100835 no 1694 0.49803544599352 2396 729761 SGTC_1380 2291-0730 164 µM 0.00326411428580803 0.49632018345016 no 1695 0.498697809115682 2399 2999191 SGTC_1847 st056231 15 µM 0.00310895488151659 0.496262340056779 no 1696 0.49875970844793 2397 5393180 SGTC_2986 9022445 71.43 µM 0.00216860767501004 0.49591178054052 no 1697 0.499134851386948 2402 6459286 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.00183850861139533 0.495788721019146 no 1698 0.499266541595228 2403 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_560 2332-1943 155 µM 0.00183105906788194 0.495785943865714 no 1699 0.499269513528103 2400 21177716 SGTC_3296 9122258 64.045 µM 0.00124358812008718 0.495566938220158 no 1700 0.499503880247368 2401 4730474 SGTC_1005 4092-0690 4.4 µM 0.000958578219057704 0.495460688715854 no 1701 0.499617582677911 2402 1529343 SGTC_522 1273-0010 11.6 µM 0.000634895694246651 0.495340022745048 no 1702 0.499746713280937 2401 5705015 SGTC_2486 5283202 22.39 µM -0.00145485434500033 0.494560993233547 no 1703 0.4994195972947 2410 1377751 SGTC_1827 berberine 7.24 µM -0.00170157284439 0.49446902134787 no 1704 0.499321170976765 2409 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1352 1496-0991 99 µM -0.00185320141019858 0.494412497296195 no 1705 0.499260680026553 2408 3000039 SGTC_2823 7987624 58.44 µM -0.00203373803424234 0.494345197053561 no 1706 0.499188656470179 2410 2239440 SGTC_621 3584-0052 32.1 µM -0.0021431633540603 0.494304405682327 no 1707 0.499145002178781 2404 2273927 SGTC_2085 5307070 144.047 µM -0.00231489310772884 0.49424038869806 no 1708 0.499076492089522 2409 2840351 SGTC_3224 9130643 49.47 µM -0.00518180026465239 0.493171693463031 no 1709 0.497932770037056 2429 17644395 SGTC_2396 5342950 42.78 µM -0.00519541959666383 0.493166616703819 no 1710 0.497927336782823 2421 1886677 SGTC_1011 4112-3381 17.4 µM -0.00520162685240664 0.493164302879783 no 1711 0.497924860479522 2461 2877139 SGTC_318 1488-0629 67.2 µM -0.00661417402860244 0.492637766247655 no 1712 0.497361345569072 2429 3662576 SGTC_1039 k821-0043 94 µM -0.00733471864590772 0.492369183190531 no 1713 0.497073896853786 2401 15992768 SGTC_2206 7254556 146.969 µM -0.00749413547280851 0.49230976102011 no 1714 0.497010300489484 2418 4398905 SGTC_85 0868-0259 160.055 µM -0.00796634391791108 0.492133747666974 no 1715 0.496821922205827 2447 83173 SGTC_1860 st056228 74.6 µM -0.00877435215926831 0.491832570178682 no 1716 0.49649958485632 2459 688679 SGTC_2950 9072895 21.46 µM -0.00904332361573429 0.49173231461723 no 1717 0.496392285028576 2429 17332245 SGTC_1469 k284-2957 126 µM -0.0105981668255483 0.491152777759839 no 1718 0.495772022307235 2439 23884841 SGTC_523 1934-0222 13.7 µM -0.0107899023120304 0.491081313442481 no 1719 0.495695535288885 2435 1361595 SGTC_543 3844-1095 191 µM -0.0123823677105793 0.490487775479699 no 1720 0.495060276217998 2443 4230703 SGTC_3303 9125618 40.5795 µM -0.0127960922421484 0.490333576957498 no 1721 0.49489523709003 2450 22695467 SGTC_3242 9133940 49.47 µM -0.0136284799433833 0.490023343643022 no 1722 0.494563191434864 2452 17248444 SGTC_3289 9119912 71.43 µM -0.0150500870263671 0.489493520611691 no 1723 0.493996110614264 2452 17014829 SGTC_718 1130-0073 349 µM -0.0159488260293049 0.489158576367906 no 1724 0.493637608703619 2448 6740020 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0159883166358926 0.48914385908595 no 1725 0.493621856239503 2449 616764 SGTC_1810 st050138 53 µM -0.0175034382060463 0.488579217896454 no 1726 0.493017494987784 2434 3444541 SGTC_734 2023-0417 80 µM -0.018757496280732 0.488111884647858 no 1727 0.492517280452963 2458 3935732 SGTC_598 3937-0236 20.2 µM -0.0196779144720942 0.487768894915233 no 1728 0.492150154533504 2444 1379313 SGTC_2639 lactacystin 53 µM -0.0207444552357162 0.48737146458923 no 1729 0.491724753244666 2455 3870 A proteasome inhibitor. SGTC_784 4579-0127 173 µM -0.0227025191386827 0.486641854547609 no 1730 0.490943783186267 2491 1948547 SGTC_2009 4012297 12.05 µM -0.0229737474722051 0.486540793432909 no 1731 0.49083560695169 2462 45595307 SGTC_1698 5-fluorocytosine 1.055 µM -0.0238008992051249 0.486232597677731 no 1732 0.490505711395835 2449 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0240560553813407 0.486137528439871 no 1733 0.490403947946935 2453 229346 A bile salt which induces apoptosis. SGTC_1763 st044482 94.5 µM -0.0241145523107674 0.486115733042623 no 1734 0.490380617816424 2491 88505 SGTC_1172 0370-0043 85 µM -0.0244902709402368 0.48597574486094 no 1735 0.490230772027012 2487 376585 SGTC_656 4090-1979 187 µM -0.0246771724229032 0.485906108289253 no 1736 0.490156231651406 2442 22330961 SGTC_1971 st069429 63.5 µM -0.0248339828475024 0.485847683507031 no 1737 0.490093692509227 2447 1246522 YGL099W LSG1 SGTC_2464 5717415 7.67 µM -0.0256685715020698 0.485536735722192 no 1738 0.489760845950727 2461 5285744 SGTC_2589 lobaric acid 100 µM -0.0270247190037926 0.48503148641558 no 1739 0.489220009157609 2465 73157 A novel microtubule depolymerizer. SGTC_541 4513-1321 94 µM -0.0273561854230991 0.484907998178216 no 1740 0.489087822062379 2470 747515 SGTC_2021 4019055 173 µM -0.0275655650217905 0.484829994286779 no 1741 0.489004323177137 2479 44827708 YER133W GLC7 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0280425808362823 0.484652285306772 no 1742 0.488814094945866 2493 804 An inhibitor of viral and cellular DNA polymerases. SGTC_52 0329-0193 875 nM -0.0296741328653694 0.484044485013343 no 1743 0.488163470908733 2551 3739292 SGTC_545 4218-0007 221 µM -0.0297321666890468 0.484022866410888 no 1744 0.48814032897383 2488 2840508 SGTC_1955 wogonin 32.4 µM -0.0297693664892877 0.484009008866986 no 1745 0.488125494966995 2581 5281703 A flavanone. SGTC_1622 st003707 19.4 µM -0.0302054993984042 0.483846543554332 no 1746 0.487951581324219 2540 10140899 SGTC_1637 st007924 17.4 µM -0.0306149888773539 0.483694005714587 no 1747 0.487788294178869 2459 683336 SGTC_511 blebbistatin 171 µM -0.0319408612137394 0.483200125014475 no 1748 0.487259606357357 2505 3476986 A myosin inhibitor. SGTC_740 k014-0057 261 µM -0.03234999045712 0.483047731621617 no 1749 0.487096471712769 2510 4012779 SGTC_1126 isoteolin 1.0172 µM -0.032940347714189 0.482827838376168 no 1750 0.486861078709217 2461 133323 SGTC_2835 9006588 71.43 µM -0.0339537388651816 0.482450387850137 no 1751 0.486457020224067 2586 2345538 SGTC_1322 1348-1070 12 µM -0.0346148087461114 0.482204172353976 no 1752 0.4861934464524 2455 6758089 SGTC_651 3253-0966 34.4 µM -0.0357715484965266 0.481773360985798 no 1753 0.485732259776331 2477 781462 SGTC_1343 1487-0095 224 µM -0.0382290193234692 0.480858181979419 no 1754 0.484752541863751 2470 4560101 YGL055W OLE1 SGTC_2165 5727197 32.143 µM -0.0388135813475183 0.480640501740481 no 1755 0.484519508322451 2693 1361712 SGTC_1875 nocodazole 6 µM -0.0410811599016162 0.479796152051354 no 1756 0.483615597071764 2477 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3072 9116419 49.47 µM -0.0416089561965846 0.479599636053369 no 1757 0.48340521670712 2501 17170162 SGTC_2327 6189656 200 µM -0.0418550309614495 0.479508015980534 no 1758 0.483307132526428 2512 5349088 SGTC_1762 st045503 25.4615 µM -0.0423221819980451 0.479334086410544 no 1759 0.48312093122457 2512 4645554 SGTC_1492 4158-0558 28.5 µM -0.0433161311179065 0.47896403263005 no 1760 0.482724766259208 2542 3967268 SGTC_2362 9071156 126 µM -0.0433718173277225 0.478943300822105 no 1761 0.482702571534091 2518 653133 SGTC_1974 st069448 26.9 µM -0.0435434917845917 0.478879387298434 no 1762 0.482634147976642 2487 6323587 YNR016C ACC1 SGTC_300 r073-0011 5.04 µM -0.0439953058639756 0.478711181823582 no 1763 0.482454072812087 2486 2735780 SGTC_1777 st045864 34.765 µM -0.044481244951106 0.47853027621182 no 1764 0.4822604007697 2487 4691462 SGTC_2050 5263056 171 µM -0.0445375493721393 0.478509315463047 no 1765 0.482237960794357 2504 763468 YGL055W OLE1 SGTC_544 k015-0020 52.4 µM -0.0474368862454617 0.477430045430081 no 1766 0.481082515562696 2530 3008304 SGTC_2720 fluspirilene 36.88 µM -0.0481996617837862 0.477146131549443 no 1767 0.480778559866714 2542 3396 An atypical antipsychotic. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0491883293056191 0.476778155341227 no 1768 0.480384605937094 2538 688761 SGTC_2020 4017018 200 µM -0.0506887129621319 0.476219759340417 no 1769 0.47978678541975 2540 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1479 0549-0158 134 µM -0.052446129915809 0.475565763022396 no 1770 0.479086609155785 2510 5440202 SGTC_2646 retinol 96.75 µM -0.0530533542503498 0.475339808819961 no 1771 0.478844698495467 2558 445354 A vitamin A analog and teratogen. SGTC_3049 9092223 49.47 µM -0.0546794872959072 0.474734747828392 no 1772 0.47819690583814 2576 8623917 SGTC_2188 6126565 140.678 µM -0.0551670216049206 0.474553354532094 no 1773 0.478002700927819 2507 874518 SGTC_2909 7941780 10.49 µM -0.056503800530814 0.474056016224095 no 1774 0.477470233989192 2500 1243215 SGTC_2352 9027995 87.8 µM -0.0574254628121801 0.473713142368652 no 1775 0.477103140037611 2552 2997347 SGTC_67 0335-0847 266 µM -0.0576249718594061 0.473638924205797 no 1776 0.477023679026536 2724 4552207 YOR254C SEC63 SGTC_756 0508-1999 28.3 µM -0.0576285435623703 0.47363759552635 no 1777 0.477022256487187 2517 6753853 SGTC_1981 st071826 47 µM -0.0576934565418206 0.473613447841081 no 1778 0.476996402969656 2569 11838600 SGTC_1091 telmisartan 47.6 µM -0.0577186543332684 0.473604074266688 no 1779 0.476986367228646 2597 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2936 9038235 15.59 µM -0.0587633252670431 0.473215469770899 no 1780 0.476570310077275 2493 4749415 SGTC_1983 st071813 46.9 µM -0.0600442296310846 0.472739024224332 no 1781 0.476060204031942 2571 11838595 SGTC_315 k915-0449 187 µM -0.0609697130701099 0.472394805374713 no 1782 0.475691664817554 2541 20970215 YNL149C PGA2 SGTC_2784 7567673 72.73 µM -0.0615137464366166 0.472192470419273 no 1783 0.475475033532693 2505 3471247 SGTC_1619 st003326 88.7 µM -0.0626872623245884 0.471756045064834 no 1784 0.475007770318144 2522 2849032 SGTC_1508 1080-0625 72.9 µM -0.0630961961169255 0.471603972341817 no 1785 0.474844951662231 2492 767111 SGTC_2508 celastrol 40.54 µM -0.064141602309343 0.471215229586873 no 1786 0.474428738087618 2497 122724 Celastrol is a natural product and antioxidant. SGTC_534 k292-0788 63.4 µM -0.0643591480887938 0.471134336862899 no 1787 0.474342128829365 2509 4146317 SGTC_715 0868-0130 184 µM -0.0646739111338874 0.471017296755886 no 1788 0.474216817611075 2561 2876258 SGTC_1347 1493-0251 600 nM -0.0657125945429747 0.470631095097541 no 1789 0.47380332254625 2555 3986378 SGTC_2904 7225135 42.03 µM -0.0677227445711023 0.469883762995873 no 1790 0.473003171662482 2581 4446116 SGTC_1235 benzylparaben 21.5 µM -0.0680063849086329 0.469778319878525 no 1791 0.472890275815866 2571 7180 SGTC_3217 9129673 49.47 µM -0.0682860265907152 0.469674365333483 no 1792 0.472778973664484 2596 17248312 SGTC_1499 4480-0877 67.3 µM -0.0685188226125119 0.469587826862004 no 1793 0.472686318504367 2524 2861909 SGTC_1973 st070275 50.2 µM -0.0689501097460188 0.469427506060142 no 1794 0.472514665792777 2494 17118334 SGTC_1817 st052116 64.4 µM -0.0691455168130261 0.46935486972991 no 1795 0.472436895262534 2586 4361398 SGTC_447 ml7 120 µM -0.06914660596272 0.469354464876186 no 1796 0.47243646179216 2542 4216 Selective myosin light chain kinase inhibitor. SGTC_1461 k072-0203 53.8 µM -0.0694372918797027 0.469246413575689 no 1797 0.472320772956302 2511 5418714 SGTC_520 3584-0023 682 µM -0.0698383621197025 0.469097334872004 no 1798 0.472161156574804 2620 1340790 SGTC_539 4859-0462 2.54 µM -0.0698653822986892 0.469087291566685 no 1799 0.472150403349031 2566 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1132 3456-3614 2.5 µM -0.0724723695527785 0.468118377047087 no 1800 0.471112996768272 2660 3125502 SGTC_595 3909-8003 73.7 µM -0.0728483152984141 0.467978668259087 no 1801 0.470963411507309 2588 699517 SGTC_2379 9035213 200 µM -0.0730845467268392 0.467890882059094 no 1802 0.470869419347933 2521 646551 SGTC_2715 st079500 56.4 µM -0.0733225448027029 0.467802440932497 no 1803 0.470774725912903 2527 28246688 SGTC_1202 1988-0068 29.6 µM -0.0741807586704417 0.467483538132545 no 1804 0.47043327800963 2547 2850480 SGTC_3065 9113888 49.47 µM -0.0745577787720659 0.467343448210124 no 1805 0.470283284117696 2635 16648368 SGTC_1378 2093-0007 380 nM -0.0745641026376533 0.467341098476382 no 1806 0.470280768263304 2594 3618014 SGTC_2485 5633444 17.78 µM -0.0751253963405994 0.467132545336489 no 1807 0.47005747077992 2583 5724239 SGTC_2581 avocatin a 64 µM -0.0761398667044075 0.466755633732802 no 1808 0.469653911567921 2589 6710728 A skin care supplement. SGTC_153 4077-0274 519.67 µM -0.0765089266380712 0.466618522297688 no 1809 0.469507106181597 2556 3121976 SGTC_2186 6124449 200 µM -0.0767287914492949 0.466536841024535 no 1810 0.469419649893577 2601 3834182 YLR033W RSC58 SGTC_1125 tnp00248 1.32998 µM -0.0772361382337009 0.466348363626606 no 1811 0.469217846672631 2609 24207736 SGTC_414 piperonyl butoxide 100 µM -0.0786926350976599 0.465807322665523 no 1812 0.468638551827621 2546 5794 A potent inhibitor of cytochrome P450. SGTC_1969 st069479 40.1 µM -0.0788023459926154 0.465766571202107 no 1813 0.468594919010175 2608 3895485 SGTC_2700 st077718 96.8 µM -0.0792098195103485 0.465615220718365 no 1814 0.468432867147693 2602 904970 SGTC_1229 0139-0193 12.2 µM -0.0798737912744496 0.465368608122044 no 1815 0.468168817373558 2562 3090752 SGTC_386 1509-0011 3.07 µM -0.080577596060257 0.465107215255155 no 1816 0.467888942005459 2551 3107280 SGTC_1247 0448-0043 5.84 µM -0.0818083449987208 0.464650151753675 no 1817 0.467399559985693 2617 3089013 YGL099W LSG1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0823326223353035 0.464455464895549 no 1818 0.46719110680023 2720 94937 An inhibitor of serotonin biosynthesis. SGTC_1986 st071812 45 µM -0.0823411313471923 0.46445230520134 no 1819 0.467187723682769 2564 11838594 SGTC_2073 5212005 126 µM -0.0832883535434166 0.464100582476342 no 1820 0.466811130322157 2533 691789 SGTC_1930 st074634 34.3 µM -0.0843373453907729 0.463711103372961 no 1821 0.466394110414459 2551 684253 YOR116C RPO31 SGTC_1219 1469-0211 33.1 µM -0.0843833053646386 0.463694039734078 no 1822 0.466375840165101 2547 6822282 SGTC_2136 5328288 199.296 µM -0.0850799555796809 0.463435401402277 no 1823 0.466098912824534 2570 262395 SGTC_3225 9130819 49.47 µM -0.0861221801458063 0.463048494038072 no 1824 0.465684645961001 2567 4547121 SGTC_1299 1079-1439 3.74 µM -0.0861388198441031 0.463042317128042 no 1825 0.465678032259122 2578 323161 SGTC_3241 9133421 49.47 µM -0.0865565841682447 0.462887239557476 no 1826 0.465511988568137 2540 17018221 SGTC_1463 k081-0032 34.1 µM -0.0898466079061177 0.461666154539987 no 1827 0.464204555090116 2569 977755 SGTC_1366 1683-0113 21.9 µM -0.090700705776822 0.461349216610635 no 1828 0.463865204907933 2564 708623 SGTC_2873 9040596 71.43 µM -0.0918157485293221 0.46093548444207 no 1829 0.46342221569947 2686 6463863 SGTC_327 1273-0057 3.96 µM -0.0935918583431269 0.460276553468058 no 1830 0.462716688663244 2610 3108138 SGTC_723 4182-0001 115 µM -0.0947161274521938 0.459859509538235 no 1831 0.462270153857317 2599 744821 YLR208W SEC13 SGTC_3152 9099253 49.47 µM -0.0958160019146688 0.459451557451467 no 1832 0.461833354072167 2647 25236131 SGTC_3052 9092717 49.47 µM -0.0962439629470726 0.459292834852882 no 1833 0.461663407734553 2705 25237534 SGTC_336 4111-0029 111 µM -0.0966298389061821 0.45914972636863 no 1834 0.46151017967589 2633 3131175 SGTC_3066 9117245 49.47 µM -0.0972544076006937 0.458918105959691 no 1835 0.461262180881258 2615 17176980 SGTC_2341 7987486 176.74 µM -0.0987790253343293 0.458352762377727 no 1836 0.460656861196113 2612 1258686 SGTC_1863 st057641 20.1 µM -0.0989330855783081 0.458295639957599 no 1837 0.460595699633731 2579 3921635 SGTC_2884 9058502 51.95 µM -0.100177500016435 0.457834267949046 no 1838 0.460101704264961 2656 6471554 SGTC_998 3996-0085 177 µM -0.100327452449035 0.457778676262445 no 1839 0.460042181769613 2631 715391 SGTC_2075 5212009 200 µM -0.101711330157411 0.457265672055653 no 1840 0.459492904312407 2637 780898 SGTC_991 3996-0057 64.7 µM -0.10191796186136 0.457189079660974 no 1841 0.45941089634922 2661 715343 SGTC_1603 st002045 67.8 µM -0.102386237657685 0.457015509260432 no 1842 0.459225053510626 2602 5887985 SGTC_1351 1496-0003 46.5 µM -0.102954504886345 0.456804887202422 no 1843 0.458999539422514 2656 3891978 SGTC_782 0083-0095 30.5 µM -0.104557803532241 0.456210707628419 no 1844 0.458363349505326 2573 3591729 An indicator and reagent. SGTC_1141 3253-0389 52.6 µM -0.105490643052839 0.455865043961396 no 1845 0.457993247162507 2569 5402031 SGTC_1972 st070201 17.4 µM -0.106064666004779 0.455652356352079 no 1846 0.457765522704954 2649 2829099 SGTC_262 fenpropimorph 62.5 µM -0.107837211839753 0.454995671216975 no 1847 0.457062412106683 2596 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2611 pyromycin 23.93 µM -0.112242246620334 0.453364249231982 no 1848 0.455315666414724 2656 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_468 gf-109203x 121 µM -0.112308896857448 0.453339571026807 no 1849 0.455289243881724 2639 2396 A protein kinase C inhibitor. SGTC_1077 5-fluorocytosine 377 nM -0.112354769729012 0.453322586043581 no 1850 0.455271058352955 2682 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2526 patulin 37.61 µM -0.112368221938534 0.453317605217167 no 1851 0.455265725468405 2705 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3295 9122362 53.5725 µM -0.113181683024491 0.45301642610861 no 1852 0.454943258587917 2682 4730473 SGTC_3312 9133330 71.43 µM -0.114282095153566 0.452609048128904 no 1853 0.454507087749816 2760 17617324 SGTC_3122 9126309 49.47 µM -0.11474908777604 0.452436180215247 no 1854 0.454322002226338 2588 17591206 SGTC_210 3551-0445 56.827 µM -0.115406518398941 0.452192832642943 no 1855 0.454061456275443 2748 2865180 YOR207C RET1 SGTC_1257 0669-0121 16 µM -0.115952027687544 0.451990926318059 no 1856 0.45384528080517 2707 4307855 SGTC_1668 st014914 51.6 µM -0.116052390575065 0.451953780910384 no 1857 0.453805510294376 2613 2839556 SGTC_1911 st060208 74.3 µM -0.116085872700244 0.451941388901428 no 1858 0.453792242532618 2714 688783 SGTC_1523 st012844 44.7 µM -0.117651456254349 0.451362006080344 no 1859 0.453171915919186 2745 4274103 SGTC_1787 fluconazole 80 µM -0.118562118837279 0.451025040499119 no 1860 0.452811139195239 2643 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2787 5284540 71.43 µM -0.118896504472743 0.450901319159578 no 1861 0.452678675572599 2686 736958 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.119253241985553 0.450769332974712 no 1862 0.45253736327723 2609 442882 SGTC_2398 5228213 48.84 µM -0.122233057110093 0.449667071323119 no 1863 0.451357223474931 2663 80771 YMR134W ERG29 SGTC_1073 triclabendazole 3.09 µM -0.122969634270281 0.449394664018687 no 1864 0.451065571887533 2671 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1960 st011366 51.8 µM -0.125488156843516 0.448463423277521 no 1865 0.450068550197074 2614 3972846 SGTC_1689 st020265 53.493 µM -0.125781790688009 0.448354868560574 no 1866 0.449952328104217 2705 5758320 YPR016C TIF6 SGTC_3124 9127567 49.47 µM -0.128512969957982 0.447345353862102 no 1867 0.448871517395449 2716 17592030 SGTC_2428 5615643 7.78 µM -0.129174695816422 0.447100813895677 no 1868 0.448609709125634 2711 2253075 SGTC_2399 5884133 200 µM -0.12943828600607 0.447003410065152 no 1869 0.448505427313679 2669 722445 SGTC_2417 cerulenin 830 nM -0.129960149549585 0.446810576556456 no 1870 0.448298977643466 2610 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_949 1165-0505 146 µM -0.129972630044005 0.446805965049668 no 1871 0.44829404052026 2647 6244267 SGTC_864 0469-0573 172 µM -0.133511120310575 0.445498795532916 no 1872 0.44689458513401 2633 689425 SGTC_2996 9066192 71.4286 µM -0.133669278292434 0.44544038340799 no 1873 0.446832049739178 2683 6472854 SGTC_298 1391-0729 10 µM -0.135091865923222 0.444915035767337 no 1874 0.446269620638788 2641 3237558 SGTC_1462 k081-0014 26.5 µM -0.135196764905518 0.44487630142176 no 1875 0.44622815242143 2660 3270634 SGTC_454 lyso-paf C-16 6.67 µM -0.135414229795982 0.444796003366271 no 1876 0.446142187004178 2707 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_823 0417-1665 178 µM -0.135953971538532 0.444596715646189 no 1877 0.445928834203241 2733 3429856 SGTC_2684 capsaicin 100 µM -0.135969495001655 0.444590984157157 no 1878 0.445922698214068 2740 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2049 5262831 67.185 µM -0.136057290799816 0.444558568885852 no 1879 0.445887995243601 2692 763417 SGTC_2309 7664088 163.95 µM -0.136211425201291 0.444501661496319 no 1880 0.445827071672687 2689 704922 SGTC_2812 7970281 58.44 µM -0.136606294551201 0.444355878473371 no 1881 0.445671000408857 2771 2233435 SGTC_1406 3909-7906 11.9 µM -0.136994974198233 0.444212387997217 no 1882 0.445517383833298 2686 X1406 SGTC_2330 7979373 200 µM -0.137158557868226 0.44415199932104 no 1883 0.445452733643026 2689 1863007 SGTC_963 1269-2853 151 µM -0.137228517997128 0.444126173180621 no 1884 0.445425085020021 2682 3668223 SGTC_2682 pyrogallin 40.03 µM -0.137315066216977 0.444094223789666 no 1885 0.445390881060681 2671 822798 An ATP competetive kinase inhibitor. SGTC_547 1120-0019 610 nM -0.137951883957246 0.443859152854972 no 1886 0.445139222448349 2633 3676939 SGTC_1790 st045711 43.5 µM -0.1381442122794 0.443788161855503 no 1887 0.445063222188729 2665 585119 SGTC_2210 7115885 190.385 µM -0.139029439941348 0.443461435578399 no 1888 0.444713442625174 2656 2927039 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.140172242323456 0.443039698610654 no 1889 0.444261951385108 2993 5282309 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.140710417942485 0.442841113928245 no 1890 0.444049357328945 2757 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2380 9035439 200 µM -0.140828234801536 0.442797641885607 no 1891 0.444002818600233 2790 6462575 SGTC_71 0417-1750 47.813 µM -0.142883652887467 0.442039345364746 no 1892 0.443191034600752 2773 6811472 SGTC_201 4262-0159 12.803 µM -0.143335518475929 0.441872668919646 no 1893 0.443012602873682 2755 1341029 SGTC_2943 9068529 45.32 µM -0.144008001169693 0.441624634075883 no 1894 0.442747075738902 2649 3270634 SGTC_1954 st077032 68.9 µM -0.145176051159668 0.441193871359548 no 1895 0.442285937001639 2742 698907 SGTC_1032 k061-1018 98.7 µM -0.145184191608682 0.441190869503846 no 1896 0.44228272347758 2871 4005393 SGTC_10 0279-0212 42.575 µM -0.145464321956772 0.441087571256532 no 1897 0.442172141522882 2691 39851 YBR002C RER2 SGTC_1581 himbacine 57.9 µM -0.145663930743968 0.441013967831941 no 1898 0.44209334834684 2655 5281825 An alkaloid muscarinic receptor antagonist. SGTC_120 rhodamine 6G 52.259 µM -0.14570663898553 0.440998219927845 no 1899 0.442076490077843 2665 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2888 9058547 12.99 µM -0.146168110741858 0.440828066384917 no 1900 0.44189433954445 2689 16476514 SGTC_2475 5812728 15.03 µM -0.146371110233573 0.44075322001213 no 1901 0.441814216176935 2653 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3112 9123419 49.47 µM -0.147167011280129 0.440459789932497 no 1902 0.441500099114379 2648 17015854 SGTC_827 3253-0474 693 µM -0.149907911006754 0.439449535521574 no 1903 0.440418635085047 2715 5402065 SGTC_1778 st046819 58.9 µM -0.149973381410403 0.439425408910223 no 1904 0.440392808134133 2675 671715 SGTC_799 1310-0557 151 µM -0.150238943465441 0.439327548487563 no 1905 0.440288051061442 2816 5354492 SGTC_3135 9127742 49.47 µM -0.15064385162977 0.439178345739578 no 1906 0.440128333751499 2752 3643468 SGTC_1464 k208-0027 110 µM -0.150902896850298 0.439082895888138 no 1907 0.440026157650811 2838 X1464 SGTC_2177 5811945 192 µM -0.152126666580486 0.438632023994624 no 1908 0.439543516046708 2826 5343475 SGTC_1760 st045453 10.4495 µM -0.152665701271798 0.438433453369514 no 1909 0.439330955029333 2712 3323419 YIL048W NEO1 SGTC_357 1325-0123 420 µM -0.152739123207292 0.438406407255375 no 1910 0.439302003437362 2747 1098503 SGTC_245 methotrexate 289.6 µM -0.154370847511065 0.437805410640059 no 1911 0.43865866921094 2742 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2755 lomerizine 42.69 µM -0.155179069327782 0.437507779454595 no 1912 0.438340074325907 2721 3949 A calcium channel blocker. SGTC_852 0418-0143 439 µM -0.156001890922104 0.43720480815926 no 1913 0.438015765365517 2735 5369229 SGTC_2852 9023854 51.95 µM -0.157889271586337 0.436509994744741 no 1914 0.4372720260291 2835 19798528 SGTC_813 k007-0158 173 µM -0.159449564610691 0.435935741954093 no 1915 0.436657345729547 2777 6523916 SGTC_2565 isoliquiritigenin 100 µM -0.160531428665306 0.435537650142238 no 1916 0.436231233079264 2838 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_927 2425-1185 123 µM -0.161885198286669 0.435039597713517 no 1917 0.435698129560411 2663 730375 SGTC_1178 0988-0033 191 µM -0.162637183120946 0.434762986635584 no 1918 0.435402054426348 2829 5392207 SGTC_674 0498-0004 451 µM -0.163757438541314 0.434350969678205 no 1919 0.434961049199801 2742 4231473 SGTC_2272 7805186 180 µM -0.164547113691676 0.43406057912839 no 1920 0.434650230396777 2683 2956062 YPR165W RHO1 SGTC_648 0375-0473 33.3 µM -0.165354242763216 0.433763806945362 no 1921 0.434332583406501 2719 1713139 SGTC_2432 5630864 12.22 µM -0.166275440797939 0.433425138533676 no 1922 0.43397009619825 2835 5714970 SGTC_685 1278-0033 54.9 µM -0.169391160387981 0.432280041868235 no 1923 0.432744488012559 2800 3590572 SGTC_278 4092-0821 23.9 µM -0.16955573463612 0.432219572876191 no 1924 0.432679768504876 2786 877900 SGTC_212 3807-4682 38.772 µM -0.169789801870113 0.43213357303284 no 1925 0.432587723702646 2775 3125501 YBL034C STU1 SGTC_3215 9129942 49.47 µM -0.169866841748393 0.432105268119075 no 1926 0.432557429273936 2771 17682944 SGTC_1239 0337-0584 35.4 µM -0.170055495737577 0.432035956982796 no 1927 0.432483246448664 2864 914301 YML130C ERO1 SGTC_1063 disulfiram 1.84 µM -0.170368083532762 0.431921117394713 no 1928 0.432360335412496 2686 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_291 SEC14.278 35.5 µM -0.170802293139745 0.431761605511093 no 1929 0.432189612953891 2795 1068044 SGTC_128 0906-2981 13.371 µM -0.171558747132889 0.431483740042124 no 1930 0.431892220763406 2838 6740226 SGTC_2796 7949634 45.45 µM -0.174616233402818 0.43036099164851 no 1931 0.430690596076 2690 2971588 SGTC_3175 9106517 49.47 µM -0.175330064186108 0.430098944475946 no 1932 0.430410144919164 2805 41468073 SGTC_2131 toluylene red 5.2905 µM -0.176264020709174 0.429756135684671 no 1933 0.430043263378132 2751 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2461 5755302 26.15 µM -0.176266546762401 0.429755208568391 no 1934 0.430042271162836 2887 2788904 SGTC_1793 st048256 72.231 µM -0.176591215235414 0.429636051428599 no 1935 0.429914747432677 2685 672022 SGTC_3048 9093155 49.47 µM -0.176682018647539 0.429602726657292 no 1936 0.429879082851137 2734 25236002 SGTC_741 4582-0002 126 µM -0.178074748338264 0.429091659090485 no 1937 0.429332136483342 2715 2912688 SGTC_1612 st002233 45.4 µM -0.178768748818279 0.428837037232235 no 1938 0.429059642389647 2713 1035021 SGTC_1043 0916-0009 19.3 µM -0.178912595263578 0.428784265106968 no 1939 0.429003166384996 2767 3101130 SGTC_1302 1159-0335 255 µM -0.178940226552056 0.428774128319437 no 1940 0.428992318144424 2712 649284 SGTC_2788 5282734 71.43 µM -0.179086441729083 0.42872048874452 no 1941 0.42893491391804 2862 743706 SGTC_761 k216-0224 480 µM -0.181616413977573 0.427792568440841 no 1942 0.427941883294791 2760 1340404 SGTC_1271 0832-2808 169 µM -0.181892454189895 0.427691348975759 no 1943 0.427833563200625 2874 3663794 SGTC_2709 st078560 56 µM -0.183028126557661 0.427274966486925 no 1944 0.427387974787644 2841 17250903 SGTC_1059 3448-6867 171 µM -0.18414210117357 0.426866617944911 no 1945 0.426950989597974 2691 3934407 SGTC_564 3555-0129 330 µM -0.186450851751908 0.426020551583911 no 1946 0.426045608785697 2729 563260 SGTC_2534 helenine 20.12 µM -0.188155229106745 0.425396182448593 no 1947 0.425377483793053 2731 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.190065153962076 0.424696736852813 no 1948 0.424629037711841 2798 4330530 SGTC_1008 4106-0037 6 µM -0.19149744696997 0.42417236322524 no 1949 0.424067940275833 2721 2905394 SGTC_55 0767-0285 6.563 µM -0.191637515770651 0.42412109013535 no 1950 0.424013076892739 2859 3116166 SGTC_1590 st077108 57.8 µM -0.192699274596818 0.423732468279948 no 1951 0.423597245797184 2753 5489485 SGTC_176 1486-1328 72.834 µM -0.19285082078474 0.423677005827836 no 1952 0.423537900623059 2826 22310231 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.19364103877967 0.423387828566523 no 1953 0.423228481019081 2876 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2219 9098279 200 µM -0.194363277601686 0.423123564110557 no 1954 0.422945720903574 2759 902349 SGTC_3342 9147791 14.508 µM -0.194701586760903 0.4229997899544 no 1955 0.422813284815051 2734 1838168 SGTC_1055 3448-0672 86 µM -0.195321211343499 0.422773113147977 no 1956 0.422570746302787 2908 748378 SGTC_1287 0971-0001 34.6 µM -0.196564611968528 0.422318318015961 no 1957 0.422084132917844 2750 4665869 SGTC_144 4161-2749 112.381 µM -0.197289870897894 0.422053089883451 no 1958 0.4218003527131 2755 797501 YMR168C CEP3 SGTC_3329 9141233 27.5565 µM -0.197790748495018 0.421869938923467 no 1959 0.421604392406007 2897 4909101 YNL103W MET4 SGTC_1922 5578187 25 µM -0.200068606757255 0.421037230740197 no 1960 0.420713462573795 2999 1350412 SGTC_2371 9071574 200 µM -0.200845796865649 0.420753196846223 no 1961 0.420409575887962 2812 45596039 SGTC_168 3970-0862 530.542 µM -0.200848644622889 0.420752156173305 no 1962 0.420408462482375 2845 3135186 SGTC_218 alverine citrate 93.75 µM -0.202672173043763 0.420085887331493 no 1963 0.419695637232798 2876 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_405 ebelactone b 50 µM -0.202700184247891 0.420075654562271 no 1964 0.419684689578644 2767 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_916 4466-0038 42 nM -0.20404731341839 0.419583598889163 no 1965 0.419158262920966 2897 5722064 YGL116W CDC20 SGTC_645 0845-0943 5.41 µM -0.204433382515433 0.419442605495494 no 1966 0.419007422756564 2807 1885106 SGTC_1751 st044839 27.194 µM -0.204441411351938 0.419439673454165 no 1967 0.4190042859547 2724 5291326 SGTC_3012 9080433 71.4286 µM -0.205437093435298 0.419076096212745 no 1968 0.418615320944362 2837 17688859 SGTC_906 1165-0455 526 µM -0.207213557545079 0.418427585138324 no 1969 0.41792153985093 2771 3252859 SGTC_623 k072-0108 16.9 µM -0.207983678471051 0.418146515696215 no 1970 0.417620855694609 2866 5382803 SGTC_954 1189-0853 2.85 µM -0.208637005533798 0.417908105031979 no 1971 0.417365810001909 2728 2828194 SGTC_746 1095-0025 46.6 µM -0.209763101651044 0.417497243385462 no 1972 0.416926286472794 2955 6749286 SGTC_2698 st077697 67.5 µM -0.210550527186226 0.417210000823155 no 1973 0.416619010183955 2825 3154499 SGTC_1026 k007-1105 30.6 µM -0.211417733089572 0.416893706550874 no 1974 0.416280660231115 2788 7066794 SGTC_1606 st000094 49.2 µM -0.211919240713614 0.416710817212717 no 1975 0.416085019789613 2791 1242210 SGTC_3022 9087993 49.47 µM -0.212625840301728 0.416453165725975 no 1976 0.415809407320064 2793 17173644 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.214466589701423 0.415782131454336 no 1977 0.415091609178807 2762 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3228 9131799 49.47 µM -0.215607475576043 0.415366351377363 no 1978 0.414646864093963 2849 17015818 SGTC_2536 dehydroabietamide 32.04 µM -0.215903579170067 0.415258455986376 no 1979 0.414531453562269 2945 3983547 SGTC_875 0709-0210 25.7 µM -0.217418623402923 0.414706498378979 no 1980 0.413941059466195 2769 6251364 SGTC_2900 5328528 85.29 µM -0.217775321509009 0.414576571347937 no 1981 0.413802086833961 2796 795359 SGTC_2093 5331342 194.4 µM -0.218427824988112 0.414338921614172 no 1982 0.413547893846185 2932 33839 SGTC_3353 9151644 39.2805 µM -0.218678212179297 0.41424773586239 no 1983 0.413450361191884 2911 4909158 SGTC_1794 st048918 76.9 µM -0.219962378222373 0.413780142327342 no 1984 0.412950227474032 2762 672303 SGTC_2448 5185112 27.17 µM -0.220416050138741 0.41361497943362 no 1985 0.412773573282883 2936 5718189 SGTC_223 busulfan 5 mM -0.221222849435721 0.413321295462101 no 1986 0.412459459350838 2898 2478 A DNA alkylator. SGTC_3008 9078912 71.4286 µM -0.224397438314691 0.412166181878153 no 1987 0.4112240318995 2834 16648731 SGTC_2643 anethole 100 µM -0.22571137998515 0.41168830983589 no 1988 0.41071295326486 2846 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1384 3089-0840 101 µM -0.226581869806635 0.411371790421878 no 1989 0.410374445728775 2926 1069836 SGTC_326 k292-0812 17.5 µM -0.226645302055001 0.411348728029715 no 1990 0.410349781425435 2868 3579357 SGTC_1176 0848-0131 83.3 µM -0.226737790567161 0.411315102049709 no 1991 0.410313819836968 2905 6769040 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.227313216173141 0.411105909632417 no 1992 0.410090098529214 2788 16486 A toxic proline analog. SGTC_605 1315-0399 119 µM -0.228082813206196 0.410826166912603 no 1993 0.409790930527387 2938 24020461 SGTC_379 3970-0972 5.9 µM -0.228472068050552 0.410684692971602 no 1994 0.409639634188642 2861 2898042 YBL034C STU1 SGTC_1198 1612-1005 86.7 µM -0.228635388846523 0.41062533779472 no 1995 0.409576158346013 3003 6998509 SGTC_2183 6420625 130.508 µM -0.229392896332432 0.410350065950844 no 1996 0.409281778441585 2799 2897619 SGTC_2732 terfenadine 20 µM -0.231295841311777 0.409658746869271 no 1997 0.408542488627944 2802 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_930 2810-3379 265 µM -0.232489029579348 0.40922541771518 no 1998 0.408079103471471 3021 1015764 SGTC_703 3875-0075 71.8 µM -0.232735988835377 0.40913574356973 no 1999 0.407983210705851 2846 2850814 SGTC_1843 st055809 45.5 µM -0.233136625901308 0.408990277111762 no 2000 0.407827657513858 2957 16413835 SGTC_940 3232-1287 54.8 µM -0.233634296696333 0.408809596340893 no 2001 0.407634449794833 2813 1585493 YIL048W NEO1 SGTC_1216 1165-0504 9.65 µM -0.233680854781275 0.408792694288844 no 2002 0.40761637597981 2930 6304004 SGTC_3055 9094636 49.47 µM -0.233880786304728 0.40872011477375 no 2003 0.407538764942195 2982 25236176 SGTC_1471 k673-0312 37 µM -0.23566937754718 0.408070956583035 no 2004 0.406844616907049 2874 24099884 SGTC_3304 9125678 46.087 µM -0.235897332265407 0.407988239906315 no 2005 0.406756169193109 2848 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_29 0299-0004 12.984 µM -0.235934902480241 0.407974607402311 no 2006 0.406741592194665 2814 16871 A napthoquinone isolated from Swertia calycina. SGTC_2154 5570129 200 µM -0.236966001845009 0.407600512377603 no 2007 0.406341582864095 2807 673366 SGTC_2104 5389443 200 µM -0.237081336470076 0.407558672846071 no 2008 0.4062968454998 3012 2244536 SGTC_184 1494-0393 24.714 µM -0.23924380746129 0.406774396670651 no 2009 0.405458267666077 2798 3090647 SGTC_1263 0774-1208 64.8 µM -0.239822707086778 0.40656450699882 no 2010 0.405233851442838 2974 906585 SGTC_2437 5741531 144.16 µM -0.241210218891202 0.406061550923375 no 2011 0.404696095585706 3021 2262990 SGTC_93 0109-0045 59.227 µM -0.241645316833024 0.405903865118655 no 2012 0.404527502348181 2784 88733 SGTC_2974 9094440 9.66 µM -0.243027480514429 0.405403050338529 no 2013 0.403992054571718 3028 25236134 SGTC_812 4251-0442 148 µM -0.243660281168924 0.405173812243084 no 2014 0.403746968667227 2900 5723007 SGTC_1217 1183-1422 255 µM -0.24393714825127 0.405073524717185 no 2015 0.403639748956437 2970 2849664 SGTC_716 1683-5115 658 µM -0.2450024201431 0.404687717306359 no 2016 0.403227278728819 2811 723597 SGTC_2074 5212007 75.395 µM -0.245293222037666 0.404582414241456 no 2017 0.403114699751377 2898 758611 SGTC_3189 9110682 49.47 µM -0.245580346292679 0.404478449676897 no 2018 0.403003552387601 2943 17122418 SGTC_1254 0550-0035 264 µM -0.247757366587947 0.403690394276293 no 2019 0.402161071562248 2970 15121435 SGTC_1840 st055363 71 µM -0.248948542247656 0.403259368097237 no 2020 0.401700292871592 2863 676033 SGTC_54 0159-0055 9 µM -0.249300083541961 0.403132185528587 no 2021 0.401564333352877 3089 3319099 SGTC_2761 levamisole 97.89 µM -0.249481056798345 0.403066716009695 no 2022 0.401494346115458 3000 26879 An alkaline phosphatase inhibitor. SGTC_1514 1189-1591 158 µM -0.249792618221052 0.40295401082534 no 2023 0.401373864317152 3059 767698 YMR146C TIF34 SGTC_2934 9036370 36.88 µM -0.250810129966046 0.402585989216655 no 2024 0.400980454642654 2950 6462800 SGTC_2441 5730946 39.09 µM -0.250922345699005 0.402545407430729 no 2025 0.400937073808363 2977 1774275 SGTC_96 0929-0093 37.281 µM -0.252425710377114 0.402001830887802 no 2026 0.400356014713395 2847 6991579 SGTC_295 k015-0027 31 µM -0.252952457404174 0.401811417997585 no 2027 0.400152476050162 2924 3887424 SGTC_572 0960-0087 17.7 µM -0.252991672545667 0.401797243114123 no 2028 0.400137324134524 2877 6796365 SGTC_2575 plumbagin 510 nM -0.255836397693826 0.400769321556006 no 2029 0.399038583820003 2812 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3140 9094243 49.47 µM -0.259448519484082 0.399465096930596 no 2030 0.397644598900372 2834 19291112 SGTC_328 k915-0120 63.5 µM -0.259915741610151 0.399296479160568 no 2031 0.397464384213843 2977 6624543 SGTC_2306 7482397 179.52 µM -0.260000975297849 0.399265720839513 no 2032 0.397431510642127 3032 891448 SGTC_1369 1866-0067 208 µM -0.260379611910694 0.399129089628423 no 2033 0.397285484026084 3004 3531355 SGTC_1294 1000-1494 117 µM -0.260388574117119 0.39912585576139 no 2034 0.39728202779754 2876 712797 YDL207W GLE1 SGTC_669 0108-0021 26.2 µM -0.260735785142033 0.399000575618283 no 2035 0.397148133873683 2971 17201 SGTC_801 0866-0028 10.1 µM -0.260992909560644 0.398907807088599 no 2036 0.397048987582591 2837 6849771 SGTC_47 0149-0135 24.25 µM -0.260995113276062 0.398907012029552 no 2037 0.397048137866255 2846 5239155 SGTC_3020 9089140 49.47 µM -0.262379684654736 0.398407567785216 no 2038 0.396514366741453 2949 17217859 SGTC_3323 9138564 53.9225 µM -0.263325298116324 0.398066560524749 no 2039 0.396149931235069 3030 43912313 YNL103W MET4 SGTC_1120 ficusin 1.78878 µM -0.265200962446344 0.397390388770839 no 2040 0.395427326758032 3017 6199 A DNA cross-linker. SGTC_1888 azatryptophan 97.5 µM -0.265211184172539 0.39738670470973 no 2041 0.395423389794259 2978 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3138 9097216 49.47 µM -0.267470309792292 0.396572707607615 no 2042 0.394553535520698 2818 25237486 SGTC_2881 9058953 51.95 µM -0.271113517463284 0.395260955359443 no 2043 0.393151862681609 2846 17122249 SGTC_859 0439-0102 54.6 µM -0.271709759167511 0.395046388562399 no 2044 0.392922598391532 3015 610143 SGTC_346 4513-0042 7.16 µM -0.27179116740001 0.395017095018763 no 2045 0.392891298528748 2884 2827372 SGTC_3113 9123498 49.47 µM -0.272091447156126 0.394909048939619 no 2046 0.39277585286373 2871 8897275 SGTC_1531 st059297 52.4 µM -0.27431085338472 0.394110717617277 no 2047 0.391922872252522 3009 7566702 SGTC_1629 st005085 44.9 µM -0.275507468808474 0.39368047346773 no 2048 0.391463194245917 2891 24207091 SGTC_2849 9019321 12.99 µM -0.276462178013955 0.393337299953506 no 2049 0.391096552787653 3019 16489627 SGTC_438 sphingosine 6.67 µM -0.277417393761178 0.392994027277544 no 2050 0.390729813635791 2869 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1340 1486-1359 257 µM -0.277694848310613 0.392894334947881 no 2051 0.390623307787451 2901 4309068 SGTC_3011 9081274 71.4286 µM -0.279927972929023 0.39209220619202 no 2052 0.389766382760429 2921 6625322 SGTC_2006 4011487 200 µM -0.281470461399427 0.39153841839297 no 2053 0.389174790510036 3061 45595294 SGTC_1223 0764-0573 147 µM -0.281802544470506 0.391419221864899 no 2054 0.389047459884488 2891 1609797 SGTC_2521 angolensin 13.4 µM -0.282553409032078 0.391149747238874 no 2055 0.388759599803758 3055 821428 A flavenoid. SGTC_601 0986-0029 62.9 µM -0.283365617804222 0.390858315871913 no 2056 0.388448290857923 2926 24747981 SGTC_3187 9109394 49.47 µM -0.283413021345879 0.390841308738642 no 2057 0.388430123914305 2949 17098090 SGTC_147 4466-0538 29.23 µM -0.286260764782185 0.389819998069009 no 2058 0.387339203199241 3134 6742687 YHR072W ERG7 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.286263260685657 0.389819103274169 no 2059 0.387338247450981 3095 688798 SGTC_2610 ononetin 44.17 µM -0.286300308111366 0.389805821641146 no 2060 0.387324061080129 2964 259632 SGTC_2712 st079126 47.7 µM -0.286447188343893 0.389753165825248 no 2061 0.387267818506156 2895 3152970 SGTC_1016 4226-1401 38 µM -0.286784764091486 0.389632154308411 no 2062 0.387138564820853 2882 2901613 SGTC_885 0865-0106 16.8 µM -0.286818471063075 0.389620071883868 no 2063 0.387125659514514 2915 2793380 SGTC_790 1575-0012 79.1 µM -0.288639178779439 0.388967589334645 no 2064 0.38642875531014 3080 378741 YLR208W SEC13 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.289952180232954 0.388497246384041 no 2065 0.38592641068561 2954 2374 Ca(2+)-ATPase inhibitor. SGTC_2267 7931562 200 µM -0.290494139229231 0.388303153624703 no 2066 0.385719116896043 2867 934880 SGTC_163 TUB2.036 7.546 µM -0.292137019621691 0.387714956495484 no 2067 0.38509093152634 3037 15992207 YJR013W GPI14 SGTC_939 1165-0479 45.3 µM -0.293067639655361 0.38738188268684 no 2068 0.384735225564737 3051 1377347 SGTC_688 0527-0193 473 µM -0.29451613162156 0.386863624762037 no 2069 0.384181769250966 2942 4007154 SGTC_3338 9144300 39.5675 µM -0.295372819808206 0.386557203967132 no 2070 0.383854547091652 2999 4901274 SGTC_2443 5493264 126.67 µM -0.295899487174855 0.386368860326065 no 2071 0.383653421357596 3091 5340055 SGTC_2086 5274770 176.623 µM -0.2968358627993 0.386034065394574 no 2072 0.383295912106774 3003 689278 SGTC_1170 0310-0127 64.8 µM -0.297186144863437 0.385908846147066 no 2073 0.383162199546769 3004 774975 SGTC_1264 0783-0040 158 µM -0.297950194681278 0.38563575396924 no 2074 0.382870588456923 2885 2855798 SGTC_873 0591-4978 488 µM -0.29815599152482 0.385562206266372 no 2075 0.382792054341024 3137 3305145 SGTC_1288 0973-0013 65.5 µM -0.299161077447104 0.385203067693443 no 2076 0.382408572879277 3037 4315430 SGTC_936 3005-4620 401 µM -0.301201717422405 0.384474206746339 no 2077 0.381630340144609 3144 777207 SGTC_947 3447-0010 211 µM -0.301223350128498 0.384466482315896 no 2078 0.381622092700791 2932 748350 SGTC_785 1270-0111 65.3 µM -0.302093385209058 0.384155855332986 no 2079 0.381290437430805 2893 6741994 SGTC_2652 actinonin 100 µM -0.30361641417489 0.383612270380484 no 2080 0.380710072436859 2924 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2775 cyproheptadine 69.59 µM -0.303697416071308 0.383583366360934 no 2081 0.380679213380373 3033 2913 A selective serotonin reuptake inhibitor. SGTC_1295 1013-0063 9.78 µM -0.304407144287208 0.383330140773823 no 2082 0.38040886277489 3054 6826038 SGTC_1040 k898-0338 155 µM -0.306239930347235 0.382676447513068 no 2083 0.379710985939263 3152 20969351 SGTC_882 0843-0131 351 µM -0.307681092164319 0.382162668010749 no 2084 0.379162504250275 2949 5425421 SGTC_1331 1472-0049 76.2 µM -0.308261337678297 0.381955866862331 no 2085 0.378941741271131 2930 24051409 SGTC_1407 3909-7909 12.3 µM -0.308392849827357 0.381909000238556 no 2086 0.378891711017082 2970 4411780 SGTC_1206 3978-0017 132 µM -0.309810256546869 0.381403992869875 no 2087 0.378352625760926 3210 3873677 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.310066004260663 0.381312894073255 no 2088 0.378255381875322 3077 521171 SGTC_1644 st010134 20.9 µM -0.311180252534241 0.380916069270435 no 2089 0.377831797249688 3050 3818134 SGTC_855 0428-0020 25 µM -0.31331592050212 0.380155829663801 no 2090 0.377020327910171 2981 6812414 SGTC_3145 9085516 49.47 µM -0.314458808523207 0.379749182569305 no 2091 0.376586298425586 3055 25236195 SGTC_2080 5212524 12.4 µM -0.315515045180723 0.37937348479477 no 2092 0.376185314801199 3044 260183 SGTC_2490 carminic acid 95.39 µM -0.316616200670045 0.378981930879358 no 2093 0.375767420708106 2930 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.319299978414252 0.378028141641968 no 2094 0.374749524525016 3072 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_897 1000-0139 31.4 µM -0.320139651011641 0.377729882251045 no 2095 0.374431234463136 3114 6151020 SGTC_237 nikkomycin 200 µM -0.321752624525067 0.377157143912481 no 2096 0.373820053668369 3105 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1023 4482-3888 16 µM -0.323488353480309 0.376541119055651 no 2097 0.373162713190355 3168 3303168 SGTC_2905 7799065 20.05 µM -0.324875637447556 0.376048986153558 no 2098 0.372637598053859 3158 1296806 SGTC_772 k072-0172 35.3 µM -0.325593599414316 0.375794371370828 no 2099 0.372365927735679 2986 5861980 SGTC_2334 9017922 200 µM -0.325612144984184 0.375787795169795 no 2100 0.372358911100451 3106 3163164 SGTC_1092 toremifene 6.32 µM -0.327122508126985 0.375252346404776 no 2101 0.371787614246571 2971 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3251 9135047 49.47 µM -0.328142941729338 0.374890721718931 no 2102 0.371401793550675 3063 17682963 SGTC_2409 alverine citrate 63.97 µM -0.328502257440223 0.374763412373428 no 2103 0.371265968859759 3210 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2563 tomatine 8.54 µM -0.328982394227818 0.374593316150836 no 2104 0.371084497700797 3183 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_270 tamoxifen 5.46 µM -0.329106377412379 0.374549397064877 no 2105 0.37103764201747 3186 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_877 0771-0151 33.1 µM -0.330761380484155 0.373963294417154 no 2106 0.370412367158934 3064 6166523 SGTC_3115 9123671 49.47 µM -0.331473144653763 0.37371131980309 no 2107 0.370143561473041 3070 3286988 SGTC_2981 9013952 38.96 µM -0.33158685900189 0.373671068307831 no 2108 0.370100621851407 3033 2996344 SGTC_3201 9113999 49.47 µM -0.333515933007848 0.372988443807394 no 2109 0.369372432224719 3176 16649224 SGTC_1691 st019933 84.6 µM -0.334540659180238 0.3726259948961 no 2110 0.368985807436351 3089 6176082 SGTC_2655 perillic acid 100 µM -0.335103482612522 0.372426970407813 no 2111 0.368773512927133 3010 5702197 An apoptosis inducer. SGTC_2083 5306046 65.942 µM -0.339356506332902 0.370924129443692 no 2112 0.367170589734316 3020 539837 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.339667854638471 0.370814188939118 no 2113 0.367053336095448 3015 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2019 4016004 108 µM -0.341517565602492 0.370161253409659 no 2114 0.366356991731415 3077 45595336 SGTC_810 3825-7150 143 µM -0.343186292447958 0.369572524870289 no 2115 0.365729158114976 3182 22330411 YGL099W LSG1 SGTC_2723 salbutamol 83.58 µM -0.343931740374027 0.36930962876346 no 2116 0.365448810496349 3105 9884233 β2-adrenoceptor agonist SGTC_3035 9091303 49.47 µM -0.344204496276906 0.36921345157303 no 2117 0.365346250567892 3031 25237002 SGTC_597 k018-0003 82.8 µM -0.344959302478534 0.368947340022897 no 2118 0.365062483382307 3132 6786234 SGTC_476 mead acid 10 µM -0.34517702649992 0.368870591751631 no 2119 0.36498064439481 2991 5312531 An omega 9 fatty acid. SGTC_1732 st034308 51.822 µM -0.347191803256129 0.368160626254075 no 2120 0.364223614176873 2909 830119 SGTC_1341 1486-1360 280 µM -0.348068122732672 0.367851969754915 no 2121 0.363894511803781 3011 3976547 SGTC_750 4073-0104 132 µM -0.348533377666652 0.367688132716509 no 2122 0.363719825772949 3070 22330957 SGTC_2558 carylophyllene oxide 100 µM -0.349396291937441 0.367384325820869 no 2123 0.363395908368377 2994 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1049 3226-0134 66 µM -0.350825119942883 0.366881459796012 no 2124 0.362859775269227 3082 5702385 SGTC_1208 2323-2347 50.3 µM -0.353119651920757 0.366074393390158 no 2125 0.361999370306884 3187 5412760 SGTC_1653 st012112 65 µM -0.353554223630095 0.365921606051379 no 2126 0.361836492717394 3192 720429 SGTC_793 0488-0545 106 µM -0.355192249814218 0.365345897766758 no 2127 0.361222785221678 3007 292548 SGTC_1999 st074831 12.5 µM -0.355222796925057 0.365335164414134 no 2128 0.361211343741269 3044 17112523 SGTC_2191 5911152 200 µM -0.356680026371934 0.364823259689601 no 2129 0.360665679983066 3080 2875902 SGTC_1744 st037937 38.9 µM -0.358489596487347 0.364187917871261 no 2130 0.359988476028468 3231 1016152 SGTC_2561 acetosyringone 100 µM -0.358894035527704 0.364045969877467 no 2131 0.35983718087724 2997 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2938 9059746 27.26 µM -0.359231013574109 0.363927713249371 no 2132 0.359711138736868 3141 6471769 SGTC_586 0957-0265 8.15 µM -0.359235897889822 0.363925999278337 no 2133 0.359709311935912 3132 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1248 0469-0687 58.6 µM -0.360627755994664 0.36343768889098 no 2134 0.359188868694396 3139 4017482 SGTC_2225 6654152 15.4 µM -0.361162815686125 0.363250031031747 no 2135 0.358988868754456 3103 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2593 nobiletin 86.24 µM -0.361410741205002 0.363163088918779 no 2136 0.358896209783867 3098 72344 An anti-infammatory. SGTC_983 1491-0821 12.2 µM -0.362024714385486 0.362947812171589 no 2137 0.358666780960619 3158 46495113 SGTC_1929 genistein trimethyl ether 50.5 µM -0.362446460503758 0.362799960873151 no 2138 0.358509212872956 3225 136420 SGTC_1574 spiramycin 23.7 µM -0.363320106415313 0.362493752403684 no 2139 0.358182887663702 2994 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2303 7774051 200 µM -0.363864762986655 0.362302897521456 no 2140 0.357979499319229 3220 2953184 SGTC_83 0170-0301 39.027 µM -0.364223726623546 0.362177130611488 no 2141 0.357845475378063 3069 3089716 SGTC_3004 9076122 71.4286 µM -0.366374465512797 0.361423907305126 no 2142 0.357042835360512 3190 44782551 SGTC_964 1287-0107 19.4 µM -0.366906882195696 0.361237529205634 no 2143 0.356844238849009 3210 51516812 YPR165W RHO1 SGTC_2808 7946468 45.46 µM -0.366978599888506 0.361212426183422 no 2144 0.356817490427628 3113 2970879 SGTC_1389 3405-0187 19 µM -0.367934020724194 0.360878061566423 no 2145 0.356461216008925 3077 799890 SGTC_2389 9091542 195.52 µM -0.369533323696064 0.360318598227866 no 2146 0.355865119676894 3103 3626624 YOL127W RPL25 SGTC_736 0958-0254 92.6 µM -0.369638387576652 0.360281855550492 no 2147 0.355825972309904 3161 6812352 SGTC_1658 st012944 20 µM -0.371856182995262 0.359506555286222 no 2148 0.354999965149685 3137 24207260 SGTC_2099 5377090 177.372 µM -0.374113000767005 0.358718206782276 no 2149 0.354160123328812 3150 2243829 SGTC_1965 Pectolinarigenin 58.4 µM -0.375532108645136 0.35822279377258 no 2150 0.353632385766408 3067 5320438 An anti-inflammatory. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.376685324994409 0.357820379631158 no 2151 0.353203734933268 3041 5355888 SGTC_3308 9128332 17.569 µM -0.376999889763174 0.357710639848963 no 2152 0.353086843417987 3216 17332805 YDL196W YDL196W SGTC_2499 avocadenofuran 51.48 µM -0.378845098432534 0.35706715324575 no 2153 0.352401447749714 3032 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2251 lansoprazole 556 µM -0.379115849626209 0.356972767302686 no 2154 0.352300918506847 3024 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1924 st058459 75.1 µM -0.380634572323132 0.356443491333454 no 2155 0.351737212006724 3138 688683 SGTC_2082 5219693 150 µM -0.381529244946347 0.356131826560738 no 2156 0.351405287486288 3052 2834649 SGTC_1901 st060216 58.6 µM -0.381757356168722 0.35605237796345 no 2157 0.351320676088094 3048 688792 SGTC_2722 naftopidil 47.16 µM -0.382456719585838 0.355808836443814 no 2158 0.351061312972028 3191 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2569 tetrandrine 100 µM -0.383546148711981 0.355429578359561 no 2159 0.350657429873561 3116 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_191 3914-0123 66.505 µM -0.383971925875875 0.355281393337483 no 2160 0.350499627716018 3038 3144412 SGTC_486 niguldipine 82 µM -0.384183032699776 0.355207929051263 no 2161 0.350421396559438 3077 1236 A calcium channel blocker. SGTC_722 3534-0461 190 µM -0.384845947192594 0.354977272588785 no 2162 0.350175777507461 3111 658262 SGTC_1808 st050063 61.5 µM -0.385052165780841 0.354905531105468 no 2163 0.350099383420953 3227 4011993 SGTC_787 4152-0075 138 µM -0.385976452691204 0.354584043724951 no 2164 0.349757054056469 3113 9566539 SGTC_1307 1187-1599 12.2 µM -0.386032301998197 0.354564621419269 no 2165 0.349736372984297 3052 1538471 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.386601879462339 0.354366565224006 no 2166 0.349525483167258 3122 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2349 9023730 187.07 µM -0.386660406001922 0.354346216326358 no 2167 0.349503815959251 3236 4126287 SGTC_2864 9034755 47.6 µM -0.388543467613878 0.353691723107875 no 2168 0.348806946601049 3168 4930451 SGTC_331 k048-0133 24.5 µM -0.389850838141106 0.353237576161429 no 2169 0.348323424336593 3083 6813582 SGTC_724 3910-0327 137 µM -0.390322039286538 0.353073944169823 no 2170 0.348149214103277 3172 2885483 SGTC_1168 k815-0004 80.5 µM -0.390833237844162 0.352896453171359 no 2171 0.347960252451617 3043 642433 SGTC_1304 1165-0502 251 µM -0.390911784590347 0.352869184137665 no 2172 0.347931221436452 3098 767425 SGTC_1741 st038134 10.228 µM -0.392791595925185 0.352216796767245 no 2173 0.347236706154943 3321 1272587 SGTC_19 0279-0214 38.434 µM -0.39294072026887 0.352165061838458 no 2174 0.347181632578969 3107 3566274 YBR002C RER2 SGTC_444 curcumin 90.4 µM -0.393685783704235 0.35190662187571 no 2175 0.34690651924039 3215 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2952 9073731 13.78 µM -0.395068974892359 0.351427016150214 no 2176 0.34639599240427 3107 16457353 SGTC_3149 9097855 49.47 µM -0.396316355021324 0.350994704086394 no 2177 0.345935831691724 3236 25236625 YMR079W SEC14 SGTC_1833 st055984 71 µM -0.396781120993562 0.350833676606665 no 2178 0.345764436834396 3117 676288 SGTC_1489 4065-0444 182 µM -0.397004976752606 0.350756126852798 no 2179 0.345681895323389 3225 2877968 SGTC_3130 9127414 49.47 µM -0.397691717125188 0.350518260024328 no 2180 0.345428721854413 3185 1494646 SGTC_49 0717-0965 32.132 µM -0.398208608996308 0.350339262409221 no 2181 0.345238210271169 3344 5889349 YGL099W LSG1 SGTC_3245 9134821 49.47 µM -0.399159135496119 0.350010185609257 no 2182 0.344887975725145 3119 17014901 SGTC_914 3820-6779 408 µM -0.399500603732742 0.349891995160943 no 2183 0.34476218948573 3058 2893481 SGTC_1485 3909-9022 254 µM -0.399646174284922 0.349841614078731 no 2184 0.344708571054068 3180 714516 SGTC_1529 apigenin 74 µM -0.399774862607786 0.349797078034931 no 2185 0.344661173501396 3339 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_488 nitrendipine 139 µM -0.400350531432266 0.349597877714429 no 2186 0.344449177182194 3144 4507 Dihydropyridine L-type calcium channel blocker. SGTC_839 0122-0028 230 µM -0.401581860212003 0.349171936573458 no 2187 0.34399589101456 3110 759448 SGTC_743 1275-0778 158 µM -0.402099018009589 0.348993097997888 no 2188 0.343805577719813 3188 2849257 YMR203W TOM40 SGTC_3274 9138298 49.47 µM -0.402402448491254 0.348888184171718 no 2189 0.343693934174349 3067 17015756 SGTC_2469 5655019 90.81 µM -0.403218712326033 0.348606010943746 no 2190 0.343393667530918 3232 2788239 SGTC_2675 theaflavin digallate 100 µM -0.403422792688434 0.348535475736982 no 2191 0.343318611005625 3179 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1192 1488-0095 21.4 µM -0.403618897463211 0.348467702023444 no 2192 0.343246493557725 3191 915875 SGTC_234 nsc-17383 10.7 µM -0.404876722144168 0.348033113527189 no 2193 0.342784064882182 3257 408974 SGTC_2027 5150920 200 µM -0.406916589114983 0.347328747511535 no 2194 0.342034625715697 3159 786715 SGTC_2323 6148992 148.28 µM -0.407697396755664 0.347059273969322 no 2195 0.341747924454149 3105 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2798 7813637 45.45 µM -0.408156703587559 0.346900793394231 no 2196 0.341579316253149 3247 956368 SGTC_44 0929-0055 61.211 µM -0.40850115413491 0.346781960738277 no 2197 0.341452891696934 3085 1379590 SGTC_1270 0831-1170 17.3 µM -0.409422606941283 0.346464141078362 no 2198 0.341114776015617 3174 6764716 SGTC_1472 k841-0093 193 µM -0.41027802553907 0.346169194086184 no 2199 0.340801004916066 3263 X1472 SGTC_637 1181-0519 7.26 µM -0.410314075712413 0.346156766090177 no 2200 0.340787783979 3176 6252091 YGR060W ERG25 SGTC_1153 4055-0057 267 µM -0.413209095862598 0.345159274000388 no 2201 0.339726712267053 3128 882706 SGTC_1556 plumbagin 1.48 µM -0.414324070913947 0.344775390680119 no 2202 0.339318393835588 3200 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_296 1222-0039 74.9 µM -0.414970748200843 0.344552814365401 no 2203 0.339081658544536 3164 5984176 SGTC_445 e6 berbamine 66 µM -0.415250786692388 0.34445644614148 no 2204 0.338979161900903 3220 6610268 A calcium/calmodulin antagonist. SGTC_587 k089-0003 57 µM -0.416163453998768 0.344142444672113 no 2205 0.33864520008886 3202 9659696 SGTC_2201 6605497 169.863 µM -0.41710016603692 0.343820282365285 no 2206 0.338302571744415 3170 670741 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.417618519783875 0.343642054261161 no 2207 0.338113027028352 3155 115019 SGTC_677 0929-0063 136 µM -0.418503558417172 0.343337827436765 no 2208 0.337789492700847 3198 1539583 SGTC_322 k048-0136 19.3 µM -0.419634343953976 0.342949274240296 no 2209 0.337376297606242 3231 6823282 SGTC_2803 7707263 71.43 µM -0.420051707457926 0.342805904425976 no 2210 0.337223840249063 3105 2199229 SGTC_170 4197-0004 226 µM -0.420932081244855 0.342503558784162 no 2211 0.336902339041801 3247 218692 SGTC_2144 5628481 200 µM -0.421599921737793 0.342274270462005 no 2212 0.336658531709539 3163 2818399 SGTC_2512 diallyl trisulfide 49.23 µM -0.426738946811992 0.340511849602803 no 2213 0.334784739874502 3218 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2077 5212015 200 µM -0.42837152012141 0.339952686950289 no 2214 0.334190328039774 3133 780900 SGTC_1553 gossypol 38.6 µM -0.42952718788873 0.339557078921014 no 2215 0.333769806266883 3171 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1500 4488-1866 171 µM -0.429565268658511 0.339544046122319 no 2216 0.333755953071631 3303 2900003 SGTC_1991 st073000 8.92 µM -0.430254568205326 0.33930817277651 no 2217 0.33350523574542 3338 4301969 YIL048W NEO1 SGTC_1781 st038725 66.3 µM -0.430320588292489 0.339285584479643 no 2218 0.333481226311975 3134 4270275 YIL048W NEO1 SGTC_3070 9117005 49.47 µM -0.432409936879549 0.338571027646552 no 2219 0.33272174862775 3254 8779016 SGTC_2727 riluzole 51.77 µM -0.433683657671023 0.338135700123935 no 2220 0.332259087768298 3213 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2314 7727897 200 µM -0.434767007864088 0.337765606965154 no 2221 0.331865777354665 3151 900724 SGTC_556 4058-0063 51.5 µM -0.435574629186924 0.337489810063045 no 2222 0.331572690817843 3222 6615692 SGTC_1943 st076331 65.2 µM -0.436623768566511 0.337131666810603 no 2223 0.331192111107949 3283 24208415 SGTC_2897 9048598 12.99 µM -0.440210050819692 0.335908538601218 no 2224 0.329892490447288 3179 6467404 SGTC_1958 st076513 41.9 µM -0.440826131375425 0.335698594106631 no 2225 0.329669437073529 3152 732122 YGL099W LSG1 SGTC_130 0136-0219 337.655 µM -0.44093724301492 0.335660735557694 no 2226 0.32962921529544 3177 234244 SGTC_3041 9091929 49.47 µM -0.441284589408914 0.335542396605664 no 2227 0.329503490597671 3356 25236887 SGTC_2856 9022925 19.48 µM -0.443283842987479 0.33486157966289 no 2228 0.328780220415684 3298 4944862 SGTC_1895 st058434 18.3 µM -0.444094879524511 0.334585547395568 no 2229 0.328486994186289 3343 5393175 SGTC_2661 dactinomycin 12.96 µM -0.44445391994816 0.334463378300156 no 2230 0.328357218616254 3219 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2555 cholic acid 100 µM -0.445524576861731 0.334099174718958 no 2231 0.327970351451769 3340 6708657 Influences liver metabolism. SGTC_2706 st078239 82.5 µM -0.445644624443353 0.334058348063475 no 2232 0.327926985403983 3255 15434492 SGTC_45 0kpi-0036 14.9 µM -0.446204636826396 0.333867920928039 no 2233 0.3277247169158 3309 2795021 SGTC_1565 sinapyl alcohol 95.1 µM -0.44646251385023 0.333780246564074 no 2234 0.32763159240218 3266 5280507 A phenol propionate derived from cinnamic acid. SGTC_2630 antimycin a 100 µM -0.447483008545676 0.333433382547428 no 2235 0.327263176712682 3156 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1396 3511-0007 98.6 µM -0.448322876829425 0.333148019853827 no 2236 0.326960096349688 3254 X1396 SGTC_3167 9103034 49.47 µM -0.450108852966278 0.33254151856144 no 2237 0.326315976819866 3280 5127859 SGTC_2116 5511452 16.8835 µM -0.450154374444471 0.332526065599549 no 2238 0.326299566071724 3308 870744 SGTC_2390 9097792 176.6 µM -0.451083914583213 0.332210581258822 no 2239 0.325964535220502 3229 4497149 SGTC_53 0973-0023 39.979 µM -0.452788573949144 0.331632331781009 no 2240 0.325350496020115 3355 674768 SGTC_463 ikarugamyin 104 µM -0.456880759968734 0.330245831419692 no 2241 0.32387837691233 3267 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_123 0083-0120 66.675 µM -0.457403746039076 0.330068802437667 no 2242 0.323690436159695 3218 16001701 SGTC_937 3122-0005 46.7 µM -0.45993713560162 0.329211797877364 no 2243 0.322780671998778 3322 759535 SGTC_2713 st079149 53.4 µM -0.463017592499008 0.328170937493447 no 2244 0.321675878535831 3270 3103253 SGTC_2153 5569715 200 µM -0.464634382918843 0.327625170408045 no 2245 0.321096652756521 3275 2054701 SGTC_1865 st057639 52.2 µM -0.464830349027234 0.327559044675599 no 2246 0.321026476143516 3253 688818 SGTC_2734 clemastine 41.6 µM -0.465061689134214 0.327480989495965 no 2247 0.320943640121356 3248 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1451 4152-0210 104 µM -0.467563249749388 0.326637434068336 no 2248 0.320048475473591 3364 659563 SGTC_1019 4262-0212 3.4 µM -0.46756656181114 0.326636317788564 no 2249 0.320047290969881 3315 4677213 SGTC_1064 honokiol 6.76 µM -0.468274738242701 0.326397673409079 no 2250 0.319794065609969 3283 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_872 0588-0139 234 µM -0.46886210218862 0.326199794839801 no 2251 0.319584103326691 3226 2047100 SGTC_1442 4112-3290 3 µM -0.469813292814042 0.325879449526921 no 2252 0.31924420824387 3224 704353 SGTC_1733 st037357 54.9 µM -0.470277604119921 0.325723123793712 no 2253 0.319078348030894 3125 1272339 YGL099W LSG1 SGTC_3258 9138477 49.47 µM -0.470486556426019 0.325652783095566 no 2254 0.319003718383972 3269 4970355 SGTC_604 1000-0114 314 µM -0.4716764429484 0.32525234380986 no 2255 0.318578877055927 3356 1572745 SGTC_825 1988-2224 89.6 µM -0.472123540951285 0.325101931481451 no 2256 0.318419305176484 3226 1180859 SGTC_2789 5281112 71.43 µM -0.472918275159162 0.324834638036536 no 2257 0.318135743069588 3250 765948 SGTC_2591 skatole 100 µM -0.47370183878472 0.324571189862887 no 2258 0.317856270958195 3319 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_472 calcifediol 10 µM -0.47444024374826 0.324323005151252 no 2259 0.317593000416715 3284 5283731 A vitamin D metabolite. SGTC_3160 9100216 49.47 µM -0.475151176919958 0.324084127681774 no 2260 0.317339611785828 3295 17191039 SGTC_3288 9119690 36.221 µM -0.475755321348422 0.323881188725724 no 2261 0.317124351732346 3248 17595618 YKL019W RAM2 SGTC_63 0099-0242 26.702 µM -0.477060504768911 0.323442941577595 no 2262 0.316659518814716 3355 3898502 YLR359W ADE13 SGTC_352 k048-0007 5.11 µM -0.477658060098711 0.323242379472943 no 2263 0.316446799740513 3330 6811911 SGTC_3208 9114115 49.47 µM -0.479309236314382 0.322688449658013 no 2264 0.31585932617548 3283 650895 SGTC_2957 9076800 11.52 µM -0.479561698999842 0.322603789143841 no 2265 0.31576954316735 3253 16459615 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.479910703095389 0.322486769700708 no 2266 0.315645445150873 3229 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_375 3970-0961 9.27 µM -0.479919724891319 0.322483744967775 no 2267 0.315642237478425 3260 2898222 SGTC_1121 fusaric acid 630.51 nM -0.480712849566463 0.322217880402578 no 2268 0.315360298683637 3221 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3292 9120825 59.784 µM -0.481015067955618 0.322116597221271 no 2269 0.315252894805642 3400 24824900 SGTC_3079 9117512 49.47 µM -0.481103707797971 0.322086893640914 no 2270 0.315221396497214 3319 7185044 SGTC_364 0083-0097 67.7 µM -0.481583320502975 0.32192619313961 no 2271 0.315050988663854 3355 5207356 SGTC_2546 rhodinyl acetate 100 µM -0.482086513914492 0.321757627406601 no 2272 0.314872244840359 3359 6708682 SGTC_2012 4023501 200 µM -0.482377340993605 0.321660219405639 no 2273 0.314768957325193 3279 3477460 SGTC_1436 4092-1007 8.32 µM -0.483470995234579 0.321294026717825 no 2274 0.314380674721226 3248 2881121 SGTC_591 4299-0174 154 µM -0.483661526520833 0.321230248106726 no 2275 0.314313050939985 3261 5509088 SGTC_407 eburnamonine 100 µM -0.488969231213109 0.319455667077951 no 2276 0.312431740216639 3261 3195 SGTC_378 3970-0959 8.33 µM -0.490118289849533 0.319072032201469 no 2277 0.312025098218321 3345 6615653 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.491390170692683 0.318647616682096 no 2278 0.311575257472881 3317 688788 SGTC_7 0192-1582 4.227 µM -0.49208009101068 0.318417495744495 no 2279 0.311331362951585 3321 252616 SGTC_2259 7964009 200 µM -0.493494759496519 0.317945856263659 no 2280 0.310831520887139 3380 313134 SGTC_1874 staurosporine 7.6 µM -0.494784040924901 0.31751627687363 no 2281 0.310376285394673 3364 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3257 9139206 32.98 µM -0.496245326279698 0.31702968396136 no 2282 0.309860667639597 3346 4910041 SGTC_1647 st011722 22.4 µM -0.498548123609066 0.316263518314728 no 2283 0.309048879460798 3383 2854783 SGTC_2198 6589944 200 µM -0.498642539560616 0.316232121901464 no 2284 0.309015615556591 3339 5290268 SGTC_2343 7990716 14.84 µM -0.499725698561161 0.315872030691468 no 2285 0.308634117373237 3263 6456862 SGTC_2078 5212016 200 µM -0.503899326296872 0.314486162940418 no 2286 0.307166062009548 3329 1899708 SGTC_2705 st078069 42.8 µM -0.503979541946561 0.314459552556681 no 2287 0.307137876651665 3329 1530061 SGTC_768 0384-0033 77.3 µM -0.504935329935794 0.314142557892393 no 2288 0.306802129313968 3269 3965305 YMR134W ERG29 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.506556002552255 0.313605362287536 no 2289 0.306233192953536 3373 140250 A respiratory chain inhibitor. SGTC_2878 9043973 25.97 µM -0.506650107581926 0.313574181925564 no 2290 0.30620017175833 3410 6465167 SGTC_649 1123-0311 367 µM -0.509346103158221 0.312681468556191 no 2291 0.305254823831985 3351 693629 YIL048W NEO1 SGTC_923 1900-2434 73.3 µM -0.509726924063572 0.312555457337352 no 2292 0.305121393840373 3346 5910570 SGTC_3263 9137018 49.47 µM -0.510013772540724 0.312460555464875 no 2293 0.3050209065053 3331 43844957 SGTC_1945 st075991 56.6 µM -0.51003647043528 0.312453046551361 no 2294 0.305012955719044 3302 1084980 SGTC_2896 9052656 71.43 µM -0.510286799629346 0.312370237856873 no 2295 0.30492527466489 3350 6469436 SGTC_374 0880-0231 82.3 µM -0.510498984116673 0.312300054819706 no 2296 0.304850963059725 3335 6833587 SGTC_2945 9067681 61.76 µM -0.510628941070675 0.312257073071157 no 2297 0.304805453292879 3421 16456930 SGTC_8 0354-0001 70 µM -0.510915551720445 0.312162288969163 no 2298 0.304705095473414 3371 4993152 SGTC_137 0438-0332 85.389 µM -0.510925064037538 0.312159143393967 no 2299 0.304701764950972 3410 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2055 5235184 200 µM -0.511625411696547 0.311927586957154 no 2300 0.304456598558064 3407 2836034 SGTC_2771 fluoxetine 41.05 µM -0.513396077500455 0.311342482078292 no 2301 0.303837144428497 3437 3386 A selective serotonin reuptake inhibitor. SGTC_420 mitomycin C 81.9 mM -0.513935743851968 0.311164247508236 no 2302 0.303648458061084 3291 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2687 chenodiol 100 µM -0.515227960814922 0.310737649466159 no 2303 0.303196866216807 3399 5702181 A cholesterol synthesis inhibitor. SGTC_1718 roemerine 11.9335 µM -0.515573108312704 0.310623749345985 no 2304 0.303076298150014 3361 235224 An aporphine alkaloid with mutagenic activity. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.515910466259708 0.310512437350405 no 2305 0.302958471887056 3323 688669 SGTC_3108 9121785 49.47 µM -0.517395715748548 0.310022582451962 no 2306 0.302439974890925 3384 17140271 SGTC_277 nystatin 15.5 µM -0.518087556786682 0.309794519136954 no 2307 0.302198590784631 3254 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1037 k284-1091 78.7 µM -0.518095855217527 0.309791784028266 no 2308 0.30219569597775 3399 3334711 SGTC_264 promethazine 12.5 mM -0.518142323695202 0.309776468515645 no 2309 0.302179486243287 3464 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_814 3342-0569 96 µM -0.518208949109142 0.309754510068804 no 2310 0.302156245786964 3449 4346283 SGTC_1654 st012436 41.8 µM -0.520411257980659 0.30902905417089 no 2311 0.301388482547664 3378 4323132 SGTC_620 0109-0052 432 µM -0.525632146467959 0.307312234035193 no 2312 0.299571908407031 3435 493037 SGTC_2903 5923464 63.88 µM -0.525860134690717 0.307237358887217 no 2313 0.29949269457455 3415 2876576 SGTC_2478 5763493 32.33 µM -0.525994897364276 0.307193104348022 no 2314 0.299445876148336 3325 1365576 YLR208W SEC13 SGTC_707 0865-0008 204 µM -0.526364933707534 0.307071603035895 no 2315 0.299317337446995 3342 723043 SGTC_1404 3909-7820 48.3 µM -0.527463275429833 0.306711087672378 no 2316 0.298935956403374 3418 23741373 SGTC_752 1896-0090 130 µM -0.530773674366487 0.305625627031668 no 2317 0.297787812473408 3403 772567 SGTC_1731 st035964 63 µM -0.531157678237901 0.305499824630853 no 2318 0.297654758904347 3303 6739575 SGTC_1354 1498-1681 81 µM -0.531180805242828 0.305492248792406 no 2319 0.297646746490545 3410 5754243 SGTC_2658 polymyxin b sulfate 77.05 µM -0.532350642539426 0.305109147555766 no 2320 0.297241581653752 3374 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2018 5133068 143 µM -0.532526705469449 0.30505150849848 no 2321 0.297180625337345 3370 785362 SGTC_2195 6536160 144.242 µM -0.53379955751931 0.304634949187561 no 2322 0.296740109972049 3302 3834386 SGTC_1123 mangostin 811.285 nM -0.535113324749368 0.304205265311382 no 2323 0.296285748257472 3368 5281650 An antioxidant. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.535623226074431 0.304038568513996 no 2324 0.296109486686466 3432 61125 An anti-inflammatory. SGTC_1853 st056710 91.2 µM -0.537270672778514 0.303500264224446 no 2325 0.295540330074049 3470 269167 SGTC_2273 7815444 169.05 µM -0.53736457910435 0.303469593098617 no 2326 0.295507902662431 3429 2824616 SGTC_2556 citropten 84.59 µM -0.537750912265994 0.303343425826183 no 2327 0.295374512630482 3347 2775 A potential DNA crosslinker. SGTC_924 2046-0044 21.3 µM -0.537880113448899 0.303301237007327 no 2328 0.295329909258985 3410 3623589 SGTC_1561 5-methoxyflavone 52.9 µM -0.539266172898594 0.302848803992311 no 2329 0.294851603129132 3409 94525 SGTC_1959 st077091 55.8 µM -0.540032809942533 0.302598690682742 no 2330 0.29458720285711 3359 821356 YKL052C ASK1 SGTC_3043 9092303 49.47 µM -0.540046996071278 0.302594063368166 no 2331 0.294582311329954 3361 25236084 SGTC_2022 5136654 200 µM -0.540171849871079 0.302553339192191 no 2332 0.294539262036301 3411 1713771 SGTC_1814 st052110 31.539 µM -0.540450112437644 0.30246258576676 no 2333 0.294443328210585 3442 674163 SGTC_577 r071-0003 38.6 µM -0.54156838303334 0.302097992647906 no 2334 0.294057938681442 3385 4568517 YMR134W ERG29 SGTC_3051 9093778 49.47 µM -0.543153125723335 0.301581652482942 no 2335 0.293512188607222 3389 17217378 SGTC_59 0330-0160 1.33 µM -0.545193821324666 0.300917339369116 no 2336 0.292810110283695 3442 4293482 SGTC_2871 9038510 12.99 µM -0.546714284414315 0.300422808354254 no 2337 0.292287519500263 3495 4945164 SGTC_2882 9058044 58.44 µM -0.547431072212522 0.300189800351556 no 2338 0.29204130649581 3399 18076804 SGTC_1750 st081859 2.357 µM -0.549283314472229 0.299588066073171 no 2339 0.291405518112383 3472 5291695 SGTC_696 1560-0013 611 µM -0.550695178102622 0.299129764165233 no 2340 0.290921325320523 3514 1650269 SGTC_2644 guaiazulene 100 µM -0.551194347217119 0.298967806170983 no 2341 0.290750227346667 3440 3515 A coloring agent. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.553783371144666 0.298128423735369 no 2342 0.289863554995031 3371 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2381 9035592 200 µM -0.555430741476317 0.297594892513517 no 2343 0.289300035205287 3399 4749657 SGTC_3192 9110362 49.47 µM -0.556448615812765 0.297265453148088 no 2344 0.28895210610587 3509 16649480 SGTC_1353 1498-1206 8.11 µM -0.557069845455125 0.297064471459748 no 2345 0.288739854616274 3498 6756808 SGTC_2163 5671233 125 µM -0.559117391898977 0.296402484738031 no 2346 0.28804080298668 3547 701023 SGTC_1135 dihydrocapsaicin 536.708 nM -0.56002636038721 0.296108825477666 no 2347 0.287730728816338 3422 107982 A Capsaicinoid. SGTC_2916 7875993 68.79 µM -0.562558941422702 0.295291332887006 no 2348 0.286867628610602 3497 1299250 SGTC_1395 3486-0190 4.35 µM -0.563210012843006 0.295081341302946 no 2349 0.286645942751151 3517 6748079 SGTC_2947 9072639 7.68 µM -0.56384763249697 0.294875755033927 no 2350 0.286428915909495 3459 16488146 SGTC_2189 6047310 154.431 µM -0.564164521675004 0.294773605733648 no 2351 0.286321085236612 3426 711535 SGTC_1949 st076024 69.1 µM -0.56454928085809 0.294649600457248 no 2352 0.286190185750554 3373 2921930 SGTC_571 k831-0106 44.2 µM -0.565737974984968 0.294266644489774 no 2353 0.28578595803246 3464 4783639 SGTC_1812 st052057 4.327 µM -0.566568027582688 0.293999366761897 no 2354 0.285503851180625 3427 3645418 SGTC_125 0133-0007 11.75 µM -0.567958012916964 0.293552041682848 no 2355 0.285031739192549 3532 26541 SGTC_721 1187-1332 279 µM -0.568751648046937 0.293296775454604 no 2356 0.284762346089107 3403 25730 SGTC_1931 st074438 57.1 µM -0.570009780951398 0.292892318287006 no 2357 0.284335532097145 3443 2787313 SGTC_2969 9091408 28.7 µM -0.570362313439801 0.292779034663837 no 2358 0.284215992439103 3337 4286311 SGTC_330 1488-0319 80.1 µM -0.570959454556311 0.292587194356049 no 2359 0.284013563684395 3451 6846614 SGTC_92 0063-0024 660.874 µM -0.573082011184592 0.291905765249248 no 2360 0.283294583297597 3497 3594437 SGTC_1677 st019204 53.9 µM -0.573509760986815 0.291768529280811 no 2361 0.283149795989394 3434 3945625 SGTC_2208 7283366 200 µM -0.575721990082464 0.291059254917902 no 2362 0.28240155466305 3496 898663 SGTC_2222 6885208 172.143 µM -0.578505264656216 0.290168040496906 no 2363 0.281461522021417 3458 609514 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.579213944568411 0.289941323065364 no 2364 0.281222411424671 3492 5377381 SGTC_3313 9133968 57.047 µM -0.581966676283466 0.289061471442536 no 2365 0.280294563586591 3471 1494643 SGTC_2721 ifenprodil 61.44 µM -0.582037052059884 0.289038993808442 no 2366 0.280270861869403 3514 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3077 9117319 49.47 µM -0.582267392441155 0.288965430113336 no 2367 0.280193292781669 3497 17154678 SGTC_1934 st074720 32.6 µM -0.582531674671747 0.288881037279739 no 2368 0.280104306302039 3475 17250992 SGTC_757 1066-0008 322 µM -0.58280021623186 0.288795296204598 no 2369 0.280013899695035 3491 6842497 SGTC_524 r073-0010 27.8 µM -0.582857986228728 0.288776852723777 no 2370 0.279994452824841 3429 2772106 SGTC_758 0868-0029 16 µM -0.583156749355509 0.288681479329471 no 2371 0.279893891905124 3509 762687 SGTC_2187 6125751 200 µM -0.585697283934092 0.28787107095908 no 2372 0.279039479811435 3468 874498 SGTC_3246 9135460 32.98 µM -0.586268836586243 0.287688898802982 no 2373 0.278847434758896 3450 41446951 SGTC_1825 st052143 62.6 µM -0.588417873387013 0.287004419832135 no 2374 0.278125921861746 3544 674173 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.590088203305325 0.286472944730473 no 2375 0.277565758610637 3549 688801 SGTC_82 0054-0107 293.755 µM -0.591175593174168 0.286127203976496 no 2376 0.277201387128367 3516 3104697 SGTC_2184 6075246 200 µM -0.592402763363229 0.285737257659635 no 2377 0.276790458170049 3490 2267320 SGTC_2968 9090663 33.37 µM -0.59308093930229 0.285521868585684 no 2378 0.276563492958052 3403 25236811 SGTC_2619 obliquin 87.91 µM -0.595949733219579 0.284611593976935 no 2379 0.275604403853007 3509 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3223 9129970 49.47 µM -0.596538756374454 0.28442486723994 no 2380 0.275407685435632 3522 17248386 SGTC_1357 1503-1303 39.5 µM -0.597034761952279 0.284267673495408 no 2381 0.275242086069454 3512 292895 SGTC_710 3448-4187 58 µM -0.604945898398154 0.28176611212491 no 2382 0.272607472400733 3540 3946412 SGTC_1663 st014140 55.4 µM -0.605551188964431 0.281575152486724 no 2383 0.272406411635919 3586 4207120 SGTC_2991 9074669 71.4286 µM -0.605924550408079 0.281457393967181 no 2384 0.272282428042216 3537 17333109 SGTC_629 3448-6466 76.7 µM -0.60650296002969 0.281275010010687 no 2385 0.2720904086813 3534 573744 SGTC_2714 st079313 56.9 µM -0.606723223450651 0.281205571616061 no 2386 0.272017303741378 3521 2939799 SGTC_3314 9135860 59.4275 µM -0.607034863810472 0.281107340639479 no 2387 0.271913887687754 3542 25252478 SGTC_1678 st019265 80.2 µM -0.608084514311426 0.280776606271675 no 2388 0.271565711171616 3581 5367020 SGTC_1057 3448-5381 134 µM -0.611295289806084 0.279766092790555 no 2389 0.270502054349094 3538 5497911 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.612530925993231 0.279377677089608 no 2390 0.270093271595993 3562 5024745 SGTC_3276 9139060 49.47 µM -0.613914412489526 0.278943096521356 no 2391 0.269635942874834 3571 4870619 SGTC_2337 9009472 200 µM -0.614488861411862 0.278762747384492 no 2392 0.269446165662383 3594 5742383 SGTC_1448 4255-0083 152 µM -0.614892688239423 0.278635999304 no 2393 0.269312795927919 3584 5399660 SGTC_898 1000-0849 28.3 µM -0.615386046736716 0.278481188245705 no 2394 0.269149901986223 3518 6751807 SGTC_1608 st001473 40.5 µM -0.616065193772485 0.278268147137786 no 2395 0.268925746468438 3440 7292267 SGTC_348 k064-0012 10.7 µM -0.616617954560512 0.278094810707622 no 2396 0.26874337451032 3480 5066323 SGTC_1511 0906-3109 28.5 µM -0.61802390007701 0.277654167481527 no 2397 0.268279792098224 3571 2882180 SGTC_1912 st060209 90.8 µM -0.61915992198864 0.277298371446316 no 2398 0.267905505673842 3498 688787 SGTC_1387 3342-1166 1.8 µM -0.619736334422472 0.27711792744042 no 2399 0.267715695041756 3506 3418228 SGTC_2540 epiandrosterone 100 µM -0.619915939655999 0.277061714359298 no 2400 0.267656565507024 3630 441302 A steroid. SGTC_3010 9080089 71.4286 µM -0.620127367464584 0.276995548559414 no 2401 0.267586967798043 3563 17027233 SGTC_108 0509-0257 621.132 µM -0.620606705384929 0.276845569618895 no 2402 0.267429213357526 3529 536624 SGTC_2963 9082507 9 µM -0.622823199380258 0.276152573510256 no 2403 0.266700355634742 3559 16459611 SGTC_2468 5987765 72.9 µM -0.623193848238002 0.276036771748688 no 2404 0.266578571901632 3522 26772094 SGTC_456 gingerol 170 µM -0.623838265648449 0.275835493307787 no 2405 0.266366903271034 3620 442793 A herb. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.624944856549553 0.275490027132354 no 2406 0.266003625288638 3539 2724 A muscle relaxant with antifungal properties. SGTC_1097 itavastatin 7.23 µM -0.625288152677811 0.275382896920203 no 2407 0.26589097710261 3567 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1516 st013856 110 µM -0.62608419127177 0.275134561186335 no 2408 0.265629860378185 3542 5281404 A mutagen and neurotoxin. SGTC_1687 st020778 55.3625 µM -0.62636607485814 0.275046649978445 no 2409 0.265537428060355 3555 4259299 SGTC_1683 st010134 710 nM -0.62647776329427 0.275011821464612 no 2410 0.265500808869961 3567 3818134 SGTC_221 trifluoperazine 10.304 µM -0.626491448663041 0.275007554018642 no 2411 0.265496322036209 3578 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2913 7966556 36.57 µM -0.628983158597899 0.274231119639464 no 2412 0.264680040983128 3518 2976516 SGTC_2408 sulbentine 18.36 µM -0.631779190458722 0.273361147364542 no 2413 0.263765586626056 3469 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_289 k017-0060 526 µM -0.634187341757007 0.272612959408477 no 2414 0.262979283754986 3539 5512909 SGTC_531 3788-1495 174 µM -0.635170662033888 0.272307744395413 no 2415 0.262658557616504 3549 2896655 SGTC_1722 st034304 3.6505 µM -0.636678395528915 0.271840085554842 no 2416 0.262167174445361 3560 4036148 YLR033W RSC58 SGTC_1042 0350-0096 82 µM -0.637596500779347 0.271555509610228 no 2417 0.261868187049573 3570 3122515 SGTC_881 0833-0569 170 µM -0.638194863174476 0.27137012106408 no 2418 0.261673420318861 3531 5418700 SGTC_692 k241-0027 77.8 µM -0.6402394114862 0.270737142033896 no 2419 0.261008482015748 3634 3600480 SGTC_1902 st060212 70.5 µM -0.640912691417009 0.270528860350626 no 2420 0.260789704827923 3609 688944 SGTC_2492 derrusnin 100 µM -0.642008758475651 0.270189959204502 no 2421 0.26043374810557 3530 1715307 Part of coumarin class of compounds. SGTC_283 0987-0079 11.7 µM -0.642849931806202 0.269930014632271 no 2422 0.260160740007773 3601 411556 SGTC_1871 st057448 67.3 µM -0.643438810546744 0.269748110209586 no 2423 0.259969703527453 3668 691747 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.643735472990412 0.269656494551034 no 2424 0.259873491516943 3601 66535 A nucleotide analog. SGTC_641 4092-0595 30 µM -0.643741370567949 0.269654673411956 no 2425 0.259871579031704 3593 786260 SGTC_1985 st071382 65.5 µM -0.646334885103885 0.268854408174609 no 2426 0.259031250093324 3632 6123237 SGTC_928 2764-0428 58.7 µM -0.648100965668996 0.268310142715502 no 2427 0.258459824733893 3582 662578 SGTC_585 0kpi-0023 191 µM -0.648350912358005 0.268233159681032 no 2428 0.25837900584736 3553 64601 SGTC_3341 9147222 25.867 µM -0.648748927737284 0.268110594755973 no 2429 0.258250336796643 3575 1939759 SGTC_913 3487-1245 167 µM -0.649528243309463 0.267870693841502 no 2430 0.257998498534778 3550 4016153 SGTC_2113 5491891 107.031 µM -0.6496904686096 0.267820768752294 no 2431 0.257946090945252 3606 789979 SGTC_200 k038-0079 37.545 µM -0.651155023144931 0.267370262097905 no 2432 0.257473210336038 3553 3436683 SGTC_448 monastrol 171 µM -0.653524395102057 0.266642238035574 no 2433 0.256709133781523 3550 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2833 9001315 45.46 µM -0.654694060408498 0.266283211189349 no 2434 0.256332375086126 3566 2989378 SGTC_1147 3809-1045 12.3 µM -0.655818535299155 0.265938286293049 no 2435 0.255970444489794 3554 325925 SGTC_2388 9080168 200 µM -0.656832337931244 0.265627503511016 no 2436 0.255644364269591 3565 15943073 SGTC_3082 9117008 49.47 µM -0.656869714514876 0.265616049182258 no 2437 0.255632346585567 3595 41448529 SGTC_1328 1441-0025 69.2 µM -0.657142280243034 0.265532526986294 no 2438 0.255544717513656 3555 4562601 SGTC_2095 5432005 200 µM -0.657890468523832 0.265303328479985 no 2439 0.255304257882687 3615 783734 SGTC_2487 5918373 44.05 µM -0.659205910902839 0.264900602131163 no 2440 0.254881775873195 3653 2876279 SGTC_2351 9026858 72.31 µM -0.660886121759414 0.264386653170402 no 2441 0.254342673436185 3565 1409300 SGTC_2753 fluvastatin 17.09 µM -0.662006446983496 0.264044246318471 no 2442 0.253983544978762 3612 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_525 k781-2675 26.7 µM -0.6621358014542 0.264004726053502 no 2443 0.253942096596568 3647 3651118 YDL195W SEC31 SGTC_220 paclitaxel 373.376 µM -0.662219000274775 0.263979308815474 no 2444 0.253915439505849 3590 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1417 3966-0327 90.4 µM -0.663407578220528 0.263616334500052 no 2445 0.253534776846822 3654 651118 SGTC_3166 9102297 49.47 µM -0.665439118840667 0.262996521829104 no 2446 0.252884835652786 3591 25237072 SGTC_368 fentichlor 4.58 µM -0.667076328886821 0.26249756000514 no 2447 0.252361689640045 3582 7329 A pesticide. SGTC_1188 1403-0014 4.57 µM -0.667442390865155 0.262386064007818 no 2448 0.252244798088415 3651 9614867 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.667598167817741 0.262338624462913 no 2449 0.252195063780375 3632 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_654 1124-0271 80.9 µM -0.669130740218231 0.261872136731706 no 2450 0.2517060411335 3631 5403748 SGTC_609 0986-0026 86.3 µM -0.673419044661951 0.260569117562536 no 2451 0.250340367958626 3624 2848610 SGTC_3197 9113331 49.47 µM -0.673593022119446 0.260516324331144 no 2452 0.250285045330476 3665 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_367 0335-0881 7.1 µM -0.673652329558418 0.260498328825372 no 2453 0.250266187797592 3603 23828853 SGTC_482 fipronil 114 µM -0.674308211788271 0.260299358834296 no 2454 0.250057692184739 3655 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1766 st045414 44.774 µM -0.674490759476595 0.26024399466671 no 2455 0.249999679274407 3678 253960 SGTC_425 3825-7017 13.1 µM -0.674756438952944 0.260163428631292 no 2456 0.249915260183554 3679 3397440 SGTC_3034 9090421 49.47 µM -0.675126060596862 0.260051364016644 no 2457 0.249797838860672 3573 17173761 SGTC_2224 6650123 117.647 µM -0.676198487854333 0.259726358540685 no 2458 0.249457316256151 3607 2908370 SGTC_1101 ebselen 5.29 µM -0.676497682047351 0.259635723370955 no 2459 0.249362358612458 3694 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_417 st075190 100 µM -0.679741698312897 0.258654059869113 no 2460 0.248334014117089 3649 222757 SGTC_1151 3909-8316 15.3 µM -0.67977899002291 0.258642786301653 no 2461 0.248322205902342 3662 800431 SGTC_480 am 92016 50 µM -0.680293139228363 0.258487381024142 no 2462 0.24815943390332 3576 2129 K+ channel blocker. SGTC_1569 carminic acid 40.6 µM -0.681880676275492 0.258007841989441 no 2463 0.247657202593647 3661 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2234 tolnaftate 200 µM -0.682013721443858 0.25796767469581 no 2464 0.247615137252215 3627 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1484 3473-2379 286 µM -0.685620486260861 0.256880003692678 no 2465 0.246476229762637 3758 671917 SGTC_1187 1391-0724 117 µM -0.686049743533184 0.256750714179633 no 2466 0.246340870425084 3696 6997986 SGTC_2818 7996756 12.99 µM -0.686360390740691 0.256657170383049 no 2467 0.246242937710709 3652 2241621 SGTC_2017 5132927 60.65 µM -0.686536018556738 0.256604292222583 no 2468 0.246187579611718 3648 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2112 5488546 200 µM -0.687457434238054 0.256326964662336 no 2469 0.24589725766496 3640 600757 SGTC_3015 9080845 49.47 µM -0.688293901999098 0.256075340061862 no 2470 0.24563386051648 3698 5296973 SGTC_921 1561-0023 372 µM -0.68833163850261 0.256063991278527 no 2471 0.245621981160277 3656 24050882 SGTC_981 1488-1094 54.9 µM -0.689941938548294 0.255579958160511 no 2472 0.24511535039847 3638 3449522 SGTC_1526 st051518 75 µM -0.690442579406 0.255429570139658 no 2473 0.244957953949168 3644 673993 SGTC_713 1488-1073 324 µM -0.691243855335919 0.255188970306621 no 2474 0.24470615406871 3640 3312542 SGTC_1046 2001-0062 216 µM -0.692710369113472 0.254748926042476 no 2475 0.244245665265308 3607 739778 SGTC_301 4119-0100 24.5 µM -0.694945432065541 0.254079034731401 no 2476 0.243544749683671 3682 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2173 5763948 167 µM -0.695122233584808 0.254026083386352 no 2477 0.243489351146141 3677 2867177 SGTC_3250 9135583 49.47 µM -0.695140704086301 0.254020551879365 no 2478 0.243483564039021 3681 7699353 SGTC_244 nsc-207895 1.295 µM -0.695802951391944 0.253822265207784 no 2479 0.243276120337388 3541 42640 SGTC_805 3852-0218 479 µM -0.697245207595887 0.25339071362369 no 2480 0.242824675810977 3632 6615355 SGTC_618 k072-0232 33.2 µM -0.697572770645314 0.253292754047869 no 2481 0.242722207625037 3661 5872756 YGL099W LSG1 SGTC_2232 chlorophetanol 41.5365 µM -0.698076800360131 0.253142060019068 no 2482 0.242564582912584 3740 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_227 fluconazole 33.516 µM -0.698500519859684 0.253015413507863 no 2483 0.242432116434849 3647 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2425 5628681 7.85 µM -0.699447148258348 0.252732594016394 no 2484 0.242136315753089 3693 5714958 SGTC_615 k087-0205 167 µM -0.700902978142741 0.252297967998629 no 2485 0.241681782876604 3675 9642773 SGTC_1260 0700-1617 7.75 µM -0.70159598715235 0.252091214392227 no 2486 0.241465577442793 3686 2853078 SGTC_2240 6690706 185.951 µM -0.701598176365726 0.252090561399858 no 2487 0.241464894616973 3611 805876 SGTC_2174 5790901 200 µM -0.701690109664413 0.252063140601269 no 2488 0.24143622114096 3695 786020 SGTC_1156 4092-0367 4.88 µM -0.701724941319322 0.252052751830087 no 2489 0.241425357827897 3696 1357585 SGTC_2826 7992541 19.48 µM -0.703771522035529 0.251442742397882 no 2490 0.240787535618309 3733 2985066 SGTC_1364 1653-0028 37.6 µM -0.703877835852185 0.251411075543387 no 2491 0.24075442771144 3673 5718652 SGTC_171 k064-0041 9.68 µM -0.704016220616938 0.25136985912744 no 2492 0.240711336084273 3652 53325 SGTC_329 k048-0121 21.3 µM -0.705050979759044 0.251061780470832 no 2493 0.24038925555245 3679 6832902 SGTC_811 0416-0114 265 µM -0.706116345189619 0.250744798244625 no 2494 0.240057893882518 3694 6612453 SGTC_3300 9124615 50.48 µM -0.70821523142877 0.250120929203811 no 2495 0.239405804416935 3710 24824903 SGTC_926 2268-1401 59.4 µM -0.709665587393189 0.249690309645156 no 2496 0.23895576846663 3686 2931578 SGTC_2930 9013230 14.89 µM -0.711073034917367 0.249272806600955 no 2497 0.238519489346147 3683 2995857 SGTC_1862 st057513 3.81 µM -0.711215963674373 0.249230429207727 no 2498 0.238475208840801 3674 5393163 SGTC_1530 rhein 70.4 µM -0.713313714687759 0.248608901451706 no 2499 0.23782582636134 3745 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_892 0929-0076 29 µM -0.714561209679423 0.248239681881522 no 2500 0.237440110534682 3702 5751038 SGTC_2683 piperine 63.03 µM -0.714866144925872 0.248149475060717 no 2501 0.237345879169302 3678 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.715104209100955 0.248079062387153 no 2502 0.237272326639326 3752 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1761 st044296 37 µM -0.718904993594421 0.246956342380596 no 2503 0.236099729734198 3715 1826700 SGTC_1234 0326-0494 15.5 µM -0.719087934663978 0.246902371785452 no 2504 0.236043370416259 3733 1547813 SGTC_946 3434-1334 87.4 µM -0.720061575354145 0.24661523815709 no 2505 0.235743542149071 3696 4047976 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.72087203526051 0.246376364184903 no 2506 0.23549412491898 3726 165521 SGTC_1996 st072960 66.8 µM -0.721719812495929 0.246126624116927 no 2507 0.235233379257603 3698 1719405 SGTC_2168 5727979 200 µM -0.723712248848061 0.245540222781053 no 2508 0.234621205828216 3662 695210 SGTC_173 1273-0061 2.693 µM -0.723760921742862 0.245525907078024 no 2509 0.234606262178454 3696 2847414 YPL266W DIM1 SGTC_729 4092-0585 94.1 µM -0.723793893313145 0.245516209713388 no 2510 0.234596139479913 3705 2169061 SGTC_2406 ethylparaben 405.7 µM -0.724506208034785 0.245306759004788 no 2511 0.234377508639491 3720 8434 A possible steroid mimic. SGTC_1090 efavirenz 20.7 µM -0.72563406077374 0.244975319050896 no 2512 0.23403156738888 3768 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1100 amiodarone 5.07 µM -0.727759686761987 0.244351320865889 no 2513 0.233380353055306 3777 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2171 5739187 198.077 µM -0.728300675206521 0.24419264530676 no 2514 0.233214774554411 3661 2262761 SGTC_550 4123-0385 25.7 µM -0.728382808101769 0.24416856003318 no 2515 0.23318964211975 3738 5731123 SGTC_1737 st035557 69.7 µM -0.728860230445328 0.244028582448561 no 2516 0.233043581999634 3642 5716916 SGTC_1164 k060-0068 93.7 µM -0.729329820040018 0.243890943620291 no 2517 0.232899967762652 3739 5963676 SGTC_1379 2144-0755 36.5 µM -0.729368616446257 0.243879574092385 no 2518 0.232888104885639 3763 5392327 SGTC_667 1498-1044 59 µM -0.729799996013458 0.24375317490257 no 2519 0.232756223463448 3739 6739982 SGTC_2282 7944268 200 µM -0.730816097857037 0.243455585145022 no 2520 0.232445744736162 3737 2970414 SGTC_2586 curcumin 80 µM -0.731111935989223 0.24336897877117 no 2521 0.232355392142622 3743 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2257 7960413 200 µM -0.731820766876138 0.243161536853633 no 2522 0.232138986002588 3703 2974689 YIL048W NEO1 SGTC_1493 4348-0038 111 µM -0.732957298574021 0.242829126381365 no 2523 0.23179223701901 3753 800424 SGTC_158 k038-0087 26.446 µM -0.733894087251702 0.242555321331518 no 2524 0.23150664549493 3679 X158 SGTC_2342 7990637 118.86 µM -0.736210106286214 0.241879112420679 no 2525 0.230801421391905 3809 2033102 YER133W GLC7 SGTC_1666 st014829 29 µM -0.736502705041344 0.241793755087414 no 2526 0.23071241098262 3755 3858230 SGTC_1706 st031321 9.9705 µM -0.736916727505171 0.241673003788113 no 2527 0.230586495476796 3738 6103185 SGTC_1106 tegaserod maleate 11.7 µM -0.738001904902704 0.241356662886273 no 2528 0.230256645783604 3777 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3311 9131146 2.8755 µM -0.738692723535397 0.241155399066059 no 2529 0.23004680262286 3745 4900406 YPR165W RHO1 SGTC_3182 9108849 49.47 µM -0.739286613944976 0.24098244737146 no 2530 0.229866487969041 3759 17133045 SGTC_1118 chelidonine 707.474 nM -0.74010566842998 0.240744034512345 no 2531 0.229617939748938 3734 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2768 sulfasalazine 50.2 µM -0.744445872094912 0.239482819802347 no 2532 0.228303388003907 3747 5384001 An antioxidant and salicylic acid derivative. SGTC_3141 9094609 49.47 µM -0.745804423500708 0.23908878260496 no 2533 0.227892783711747 3716 25236309 YDL196W YDL196W SGTC_3165 9101544 49.47 µM -0.746233396403439 0.23896443602896 no 2534 0.227763218656836 3749 5002184 SGTC_1193 1488-0126 41.5 µM -0.747579994386015 0.238574326866057 no 2535 0.227356767687317 3770 1384710 SGTC_1719 st032227 49.2 µM -0.748296593895578 0.238366870324322 no 2536 0.227140639275125 3776 3125804 SGTC_2907 7721985 69.9 µM -0.749122890026186 0.23812777914736 no 2537 0.226891569884128 3751 3267881 SGTC_1360 1598-0022 39.8 µM -0.749710591133827 0.237957806138522 no 2538 0.226714513677581 3812 761525 SGTC_2724 maprotiline 69.64 µM -0.751358634947312 0.237481519229849 no 2539 0.226218425042432 3712 4011 A tricyclic antidepressant. SGTC_139 0099-0334 718.624 µM -0.752581076672271 0.237128570216911 no 2540 0.225850846263845 3791 97690 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.752691333444665 0.237096750548847 no 2541 0.225817709519159 3794 6708784 An antioxidant flavonoid SGTC_1477 0139-0234 16 µM -0.753368543865572 0.236901361771777 no 2542 0.225614239950766 3767 620880 SGTC_398 bronopol 33.3 µM -0.754872228693014 0.236467835229965 no 2543 0.225162825185408 3680 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_999 SEC7.066 22.7 µM -0.755582931951179 0.236263084825651 no 2544 0.224949646205745 3761 740511 YDR170C SEC7 SGTC_2821 7996764 71.43 µM -0.756069605770197 0.23612293262878 no 2545 0.224803731986335 3790 2987135 SGTC_69 0096-0274 206.684 µM -0.75628409890445 0.236061177496982 no 2546 0.224739439840201 3864 6741392 SGTC_2236 dapsone 200 µM -0.758591433638087 0.235397431353846 no 2547 0.224048499328594 3776 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2281 7943571 200 µM -0.759257375590625 0.235206052954513 no 2548 0.223849305006463 3874 1244024 SGTC_1768 st044301 37.178 µM -0.759290377566243 0.235196571081624 no 2549 0.22383943618457 3782 3931349 SGTC_101 0490-5701 117.494 µM -0.759711681969145 0.235075543701828 no 2550 0.223713472181497 3641 4661669 SGTC_2459 5811157 9.22 µM -0.7606056256214 0.234818856047743 no 2551 0.223446329311835 3755 2870684 YBR192W RIM2 SGTC_3025 9087895 49.47 µM -0.761419980937149 0.234585156366081 no 2552 0.22320312837836 3786 17173641 SGTC_2603 homopterocarpin 100 µM -0.765143241331187 0.233518313721597 no 2553 0.222093126673549 3826 101795 A weak amylase inhibitor. SGTC_2457 5731572 11.68 µM -0.765444110985078 0.233432221844563 no 2554 0.222003567336691 3827 2865357 SGTC_519 k048-0011 62.8 µM -0.768374076405863 0.232594752737767 no 2555 0.221132488539165 3858 6836379 SGTC_1767 st044992 70.3 µM -0.769157159237788 0.232371208152097 no 2556 0.220900009597587 3808 9600693 SGTC_307 1501-1223 22.3 µM -0.77010735039582 0.232100120155482 no 2557 0.220618108094254 3779 2830329 SGTC_640 3381-0960 37.1 µM -0.770108398673295 0.232099821180866 no 2558 0.220617797206479 3817 1745025 SGTC_106 0092-0003 11.579 µM -0.773974662283415 0.230998600677702 no 2559 0.219472887565109 3753 1072148 SGTC_2816 7982706 58.44 µM -0.775558091013617 0.230548438938745 no 2560 0.219004976702605 3837 2981853 SGTC_1806 st050005 60.3 µM -0.775656237926272 0.230520552353782 no 2561 0.218975992710109 3793 5194765 SGTC_2034 5197015 53.07 µM -0.776117505520869 0.230389517163107 no 2562 0.218839804260634 3775 780676 SGTC_668 1682-0499 62.6 µM -0.776574319161882 0.230259788287636 no 2563 0.218704978875799 3815 682214 SGTC_1525 8-methoxypsoralen 92.5 µM -0.776695213325807 0.230225462823378 no 2564 0.218669305801924 3799 4114 Related to psoralen; DNA damaging agent. SGTC_815 1582-0027 36.9 µM -0.77676051950059 0.230206921640336 no 2565 0.218650036852359 3846 3128206 SGTC_3121 9125696 49.47 µM -0.777134372359629 0.230100796540743 no 2566 0.218539748304618 3853 1235365 SGTC_1792 st045773 43.6 µM -0.778191283850985 0.229800920650235 no 2567 0.21822812722605 3712 2919270 SGTC_1563 conessine 56.1 µM -0.77901857427293 0.229566347554929 no 2568 0.217984386650084 3855 441082 An anti-amoebic, histamine inhibitor. SGTC_1268 0828-0275 2.46 µM -0.779317588135132 0.229481597036752 no 2569 0.217896328274792 3865 745337 SGTC_257 daunorubicin 18.5 µM -0.779550657186354 0.229415549642327 no 2570 0.217827704609046 3839 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1139 k015-0024 46.9 µM -0.780034501388084 0.229278471299949 no 2571 0.217685283790313 3779 2766652 SGTC_1796 st049173 110.4 µM -0.781238847661139 0.228937466350879 no 2572 0.217331014680654 3746 94134 SGTC_3327 9140648 26.9345 µM -0.781239011801261 0.228937419894785 no 2573 0.217330966420087 3800 8029710 SGTC_2216 7189485 200 µM -0.781748686964248 0.228793193552237 no 2574 0.217181141302415 3790 731273 SGTC_542 3381-0244 89.3 µM -0.783544378812914 0.228285460705319 no 2575 0.216653751849903 3839 1112843 SGTC_1321 1326-2144 215 µM -0.784507620955205 0.228013364659893 no 2576 0.216371155969226 3825 3513030 SGTC_792 4534-1957 155 µM -0.784730099279029 0.227950545062073 no 2577 0.216305915643921 3778 1717904 SGTC_2516 gossypol 71.55 µM -0.784883363571229 0.227907274595158 no 2578 0.216260978509745 3846 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_119 0121-0043 24.815 µM -0.785521713456906 0.22772710165579 no 2579 0.216073872287269 3877 1092378 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.785522241781657 0.227726952570431 no 2580 0.216073717469269 3863 6708561 SGTC_2414 st077232 92.9 µM -0.786872684017102 0.227346057509034 no 2581 0.21567819974065 3784 729801 SGTC_3054 9094397 49.47 µM -0.788113251575179 0.22699646937725 no 2582 0.215315232306454 3828 2598354 SGTC_952 1185-0122 232 µM -0.788724268397487 0.226824398192128 no 2583 0.215136590292448 3760 678600 SGTC_3221 9128209 49.47 µM -0.791175848290682 0.226134738216592 no 2584 0.214420691521666 3855 16460723 SGTC_878 0828-0289 13.7 µM -0.791699659193807 0.225987537477793 no 2585 0.214267910548045 3805 745350 YLR208W SEC13 SGTC_1597 7-benzyloxygramine 47.5 µM -0.791766823779425 0.225968666882026 no 2586 0.214248325100608 3793 260807 SGTC_1305 1181-0477 144 µM -0.792634835392345 0.225724870069965 no 2587 0.213995303346052 3843 6252086 SGTC_410 α-linolenic acid 100 µM -0.794673289428115 0.225152918696904 no 2588 0.213401786860046 3910 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1772 st048439 82.2 µM -0.795618254889791 0.224888058153753 no 2589 0.213126976452731 3863 2927068 YDL195W SEC31 SGTC_552 k242-0005 476 µM -0.795641947557422 0.224881419702389 no 2590 0.213120088916358 3882 4088318 SGTC_2804 7954240 19.48 µM -0.796559132663958 0.224624518901619 no 2591 0.21285356000267 3865 828705 SGTC_2978 9011784 42.97 µM -0.797258941861304 0.224428616462623 no 2592 0.212650330239925 3855 2994934 SGTC_943 3253-1379 105 µM -0.797412207252635 0.224385724766573 no 2593 0.212605835968012 3795 668464 SGTC_1962 st076595 64.5 µM -0.798671640050723 0.22403344565666 no 2594 0.212240417667868 3831 279619 SGTC_233 rapamycin 362 pM -0.798940612895464 0.223958251323231 no 2595 0.212162424106443 3840 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_427 1354-0053 47.3 µM -0.799665328988844 0.223755720312032 no 2596 0.211952362926355 3956 6813657 SGTC_2121 5257820 149.641 µM -0.800007373432129 0.223660167876809 no 2597 0.211853262568694 3893 791256 SGTC_3080 9117754 49.47 µM -0.801105965882165 0.223353425609955 no 2598 0.21153515136888 3850 9550191 SGTC_2484 5809818 12.04 µM -0.801178268179582 0.223333246204014 no 2599 0.211514225146629 3836 2870548 SGTC_1367 1812-0510 76.9 µM -0.802507511567803 0.222962442331431 no 2600 0.211129722524388 3876 1142582 YDR527W RBA50 SGTC_1233 0325-0408 14.2 µM -0.803509170183807 0.222683252889655 no 2601 0.210840249308217 3896 12874 SGTC_159 3970-0959 50 µM -0.804234686714499 0.222481156238646 no 2602 0.210630724892019 3911 6615653 SGTC_370 0180-0345 38.7 µM -0.804519590222628 0.222401823397676 no 2603 0.210548480045603 3745 3989527 SGTC_104 0074-0074 590.992 µM -0.806163070734828 0.221944502953029 no 2604 0.210074414481278 3664 3943124 SGTC_2666 tannic acid 100 µM -0.806358004939613 0.221890295547714 no 2605 0.210018226912907 3849 16134267 A thiamine antagonist. SGTC_967 1306-0166 352 µM -0.806483788204027 0.221855321685837 no 2606 0.209981976004608 3788 4437607 SGTC_2580 diallyl disulphide 81.36 µM -0.807511872942541 0.221569582212863 no 2607 0.209685818454903 3863 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2557 derrustone 83.84 µM -0.808382032536528 0.221327899914679 no 2608 0.209435346000301 3796 629853 An antioxidant. SGTC_1892 st058411 7.36 µM -0.808509281511118 0.221292569814064 no 2609 0.209398732579068 3838 3934738 SGTC_250 brefeldin a 552.239 µM -0.809175713211408 0.221107590765949 no 2610 0.209207041324843 3721 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_647 0140-0236 81 µM -0.810037456983068 0.220868530870097 no 2611 0.208959324062984 3857 990837 SGTC_665 3914-0008 307 µM -0.811452773430501 0.220476223379331 no 2612 0.208552851658874 3810 1069549 SGTC_1312 1218-2183 165 µM -0.812053224054827 0.220309906921792 no 2613 0.208380545926957 3836 6744073 SGTC_1748 st037455 53.6035 µM -0.81271541357845 0.220126573079195 no 2614 0.208190620952238 3860 580690 SGTC_3143 9086658 49.47 µM -0.813944724727587 0.219786458015557 no 2615 0.207838308723844 3938 25236626 SGTC_905 2-aminofluorene 215 µM -0.814115778683751 0.219739156221872 no 2616 0.207789313742031 3860 1539 An established DNA mutagen. YPR165W RHO1 SGTC_160 3453-0671 289.699 µM -0.815267207144814 0.219420902193541 no 2617 0.207459687660916 3896 5322268 SGTC_3103 9120822 49.47 µM -0.816184598928458 0.219167525409879 no 2618 0.207197281980015 3864 17141819 SGTC_1177 0983-0204 23.6 µM -0.816758205922604 0.219009184932586 no 2619 0.207033310391941 3904 766818 SGTC_3348 9149464 3.537 µM -0.816841178150011 0.21898628643721 no 2620 0.207009598266471 3826 1951442 SGTC_1917 st066507 28.5 µM -0.818290321796518 0.218586577023875 no 2621 0.206595715553225 3835 3156428 SGTC_2594 a-mangostin 100 µM -0.819661624699955 0.218208725089605 no 2622 0.206204516229317 3902 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2855 9016525 58.44 µM -0.820148758662373 0.218074589738452 no 2623 0.206065654544568 3829 43811474 SGTC_833 3852-0053 558 µM -0.82199176096825 0.217567537926075 no 2624 0.205540793031204 3928 3123681 SGTC_508 roscovitine 141 µM -0.82227485348584 0.217489713071497 no 2625 0.205460242585748 3912 160355 A CDKinase inhibitor. SGTC_3179 9107801 49.47 µM -0.822422232035618 0.217449203652741 no 2626 0.205418315278083 3857 4818259 SGTC_2830 7992007 71.43 µM -0.8224889473699 0.217430867277971 no 2627 0.205399337291739 3770 1952075 SGTC_1466 k213-0079 57.5 µM -0.823182893069049 0.217240192725816 no 2628 0.205201997771427 3813 3657981 SGTC_738 1315-0003 72.4 µM -0.825415677781965 0.216627349082711 no 2629 0.204567818561599 3881 6251474 SGTC_614 0462-0418 107 µM -0.825440313949027 0.216620592652931 no 2630 0.204560827647307 3696 5188303 SGTC_2261 9010538 184.68 µM -0.826632519921152 0.216293777762346 no 2631 0.204222689681509 3863 6457250 SGTC_1951 sophoraflavanone G 9.2 µM -0.829039217748727 0.215634909259465 no 2632 0.203541107952677 3865 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3057 9095946 49.47 µM -0.829379047874477 0.215541969676417 no 2633 0.203444976799797 3882 24540043 SGTC_1124 fisetin 1.16336 µM -0.8294832933317 0.215513464414427 no 2634 0.203415493272308 3898 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2614 arthonioic acid 13.39 µM -0.829934752627298 0.215390040961878 no 2635 0.203287837399745 3803 6710684 SGTC_1290 0986-0249 10.2 µM -0.830113138772422 0.215341283675893 no 2636 0.203237409623137 3793 53329 SGTC_319 1348-1596 45.5 µM -0.83063612732968 0.215198375058039 no 2637 0.203089609619603 3960 5380505 SGTC_1782 st039423 80.636 µM -0.830968130664457 0.215107682452422 no 2638 0.202995816604257 3908 2068169 SGTC_479 n-linoleoylglycine 10 µM -0.831433169390618 0.214980686183106 no 2639 0.202864483761156 3902 6433346 An anti-infammatory. SGTC_3159 9100096 49.47 µM -0.831532739460335 0.214953500500849 no 2640 0.202836370507387 3834 25236875 SGTC_2159 5658611 73.75 µM -0.838039964893632 0.213181161704236 no 2641 0.20100412921073 3841 793844 SGTC_1681 tripelennamine 100 µM -0.839665774387757 0.212739682881317 no 2642 0.200547904494598 3849 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2217 6934799 96.0675 µM -0.841772954221891 0.212168285799184 no 2643 0.199957526707703 3816 675606 SGTC_311 1315-0136 58 µM -0.842264141596359 0.212035221183955 no 2644 0.199820058933608 3968 6759207 SGTC_1717 st033143 58.0435 µM -0.84236983492844 0.212006594821482 no 2645 0.199790486154315 3892 674616 SGTC_1303 1160-0052 261 µM -0.843076726711618 0.211815195826046 no 2646 0.199592766965425 3869 3562476 SGTC_1745 st081495 74 µM -0.843538623580428 0.211690186625301 no 2647 0.199463637025294 3814 13842402 YBL026W LSM2 SGTC_1667 st014849 34.6 µM -0.844236589785045 0.21150136883421 no 2648 0.199268605931983 3930 5348460 SGTC_484 loperamide 105 µM -0.84675469407072 0.210820977112203 no 2649 0.198565932969374 3873 3955 An opioid-receptor agonist. SGTC_1940 st075990 51.1 µM -0.846837727652185 0.210798563324388 no 2650 0.198542788064203 4012 1084979 SGTC_1685 st024049 53.0905 µM -0.847362266730482 0.210657003428126 no 2651 0.198396614868321 3924 1941139 SGTC_2016 5121758 140 µM -0.847391151905605 0.21064920966688 no 2652 0.198388567329445 3851 2795203 SGTC_35 0133-0054 64.071 µM -0.849317403197996 0.210129852911038 no 2653 0.197852349760505 3913 99677 SGTC_3123 9126162 49.47 µM -0.849428980543367 0.210099792440794 no 2654 0.197821316421202 3980 25239884 SGTC_1207 2099-0101 141 µM -0.849835208218647 0.209990370466734 no 2655 0.197708355955556 3934 5837381 SGTC_1505 k297-0037 20.6 µM -0.850277307438793 0.209871324151987 no 2656 0.197585464931342 3912 4089396 SGTC_2299 7976368 114.88 µM -0.850965901681072 0.209685981895864 no 2657 0.197394147289379 3957 2979718 SGTC_1094 duloxetine 25.4 µM -0.851056383670397 0.20966163489004 no 2658 0.197369016285401 3901 60834 A selective serotonin reuptake inhibitor. SGTC_1142 3253-1408 9.78 µM -0.851833520606906 0.209452590387395 no 2659 0.197153249359375 3848 256655 SGTC_2844 9010103 25.97 µM -0.853206557140724 0.209083552859208 no 2660 0.196772383875855 3974 2480525 SGTC_3003 9075612 71.4286 µM -0.853694551973451 0.20895248445838 no 2661 0.1966371267833 3941 6501993 SGTC_626 0214-0009 33 µM -0.855321288916169 0.20851591600133 no 2662 0.196186652515718 3971 3437874 SGTC_37 0566-0070 1.56 µM -0.855425857067109 0.208487871387699 no 2663 0.196157717036033 3915 1626686 SGTC_1390 3413-2614 145 µM -0.855469083904338 0.208476278833091 no 2664 0.196145756317629 3946 3421432 SGTC_1670 st016595 4.04 µM -0.856480297386457 0.208205200503872 no 2665 0.195866083202281 3911 597879 SGTC_1301 naphtanilide LB 4.81 µM -0.856933820859428 0.208083691010428 no 2666 0.195740730046538 3978 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1249 0481-0015 10.2 µM -0.861405032420968 0.206887991503724 no 2667 0.194507502675879 3866 4227577 SGTC_131 0141-0277 33.849 µM -0.861670798365862 0.206817048167803 no 2668 0.194434349635427 3889 1547771 SGTC_22 0964-0034 14.468 µM -0.862080389976854 0.206707740334583 no 2669 0.194321640859522 3956 138402 SGTC_2387 9077560 195.08 µM -0.862730381041322 0.206534347261766 no 2670 0.194142862190718 3895 5303272 SGTC_2440 5628896 157.78 µM -0.862786845657432 0.206519288702627 no 2671 0.19412733644853 3931 5522048 SGTC_2621 lithochol-11-enic acid 100 µM -0.862901450244926 0.206488726783298 no 2672 0.194095826627095 3846 6708711 SGTC_2439 5492030 7.2 µM -0.864942879433588 0.205944782339505 no 2673 0.193535070503602 3909 5722370 SGTC_143 4032-1194 15.74 µM -0.866519767264735 0.205525198640275 no 2674 0.193102595497578 3940 1806963 SGTC_1075 aripiprazole 15.2 µM -0.867768653998984 0.205193251045987 no 2675 0.192760496647532 3948 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1437 4092-1038 11.6 µM -0.868000536560596 0.205131652951695 no 2676 0.192697019454633 3946 3977136 SGTC_627 1391-0720 175 µM -0.868047256075065 0.205119243546739 no 2677 0.192684231666408 3910 997839 SGTC_231 b-estradiol 524 µM -0.869592714349582 0.204708998132727 no 2678 0.192261510355606 3882 450 A steroid. SGTC_2242 6630449 61.2675 µM -0.870587303834365 0.204445240407026 no 2679 0.191989765602304 4008 691249 YDR170C SEC7 SGTC_1520 flindersine 88 µM -0.870822708323187 0.204382842505452 no 2680 0.191925482093477 4071 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2842 9000675 19.48 µM -0.870958513225413 0.204346850299297 no 2681 0.191888402916225 3991 2989072 SGTC_1060 3448-7350 82 µM -0.871460782441435 0.204213767296339 no 2682 0.191751305107711 3883 570178 SGTC_2956 9076196 2.52 µM -0.873330698748588 0.203718761720419 no 2683 0.191241426220635 3952 16423868 SGTC_3275 9138069 49.47 µM -0.87570276475309 0.203091857093956 no 2684 0.190595820975832 4032 17617007 SGTC_3131 9127911 49.47 µM -0.878742274390015 0.202290242000571 no 2685 0.189770515838489 3985 45595681 SGTC_2145 5634607 200 µM -0.878761201820973 0.202285256173256 no 2686 0.189765383448675 3902 308662 SGTC_324 1315-0088 19.6 µM -0.878882468754156 0.202253314015985 no 2687 0.189732502555558 3915 6787421 SGTC_2455 5377712 9.75 µM -0.879395994824705 0.202118082800497 no 2688 0.189593301494802 3951 2243908 SGTC_2970 9090938 41.86 µM -0.884174197645904 0.200862393490229 no 2689 0.188301092343361 4025 17217104 SGTC_1688 st021091 57.6 µM -0.884444124283036 0.200791598008155 no 2690 0.188228256344138 3957 3656366 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.88468830271931 0.200727568583386 no 2691 0.188162383121383 3975 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2875 9039966 71.43 µM -0.88640610927109 0.20027746512701 no 2692 0.187699364159047 3978 6463691 SGTC_2260 7964312 200 µM -0.888129211990015 0.199826583759723 no 2693 0.187235625415595 4024 231951 SGTC_2806 7952793 58.44 µM -0.888701314633243 0.199677017741432 no 2694 0.187081812190027 4018 2972490 SGTC_3298 9116858 71.43 µM -0.888963413211695 0.199608519252605 no 2695 0.187011371529042 4019 2506942 SGTC_1433 4060-0023 7.6 µM -0.890626457912264 0.199174218310897 no 2696 0.186564800133739 3962 3840627 SGTC_2419 paclitaxel 166.5 µM -0.892020078299375 0.198810715719714 no 2697 0.186191085273403 3889 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1003 4049-0218 100 µM -0.892627395485543 0.198652432378073 no 2698 0.186028371634416 4001 295161 SGTC_980 1473-0395 201 µM -0.893625398933934 0.198392490705435 no 2699 0.185761176078544 3852 768876 SGTC_2254 7938975 95.19 µM -0.894177192054024 0.198248857884924 no 2700 0.185613546705787 4036 2969277 SGTC_876 0720-0963 56.8 µM -0.895043858651457 0.198023389640682 no 2701 0.185381821590804 4012 765861 SGTC_965 1291-5240 308 µM -0.895896535952398 0.197801711987655 no 2702 0.185154012219414 3970 2834598 SGTC_2911 7942208 15.64 µM -0.896538248534297 0.197634979522227 no 2703 0.184982680909301 4002 1243384 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.89713596885331 0.197479753750268 no 2704 0.184823183765525 4002 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1975 st070967 30.8 µM -0.899891291961259 0.196765160082676 no 2705 0.184089052367404 3923 261391 SGTC_2719 novobiocin 32.65 µM -0.900859438139303 0.196514443410799 no 2706 0.183831529982843 3964 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3210 9128157 49.47 µM -0.902040608907062 0.196208822960936 no 2707 0.183517648087682 4029 17590849 SGTC_1679 SEC14.276 6.7 µM -0.903391843840509 0.195859553140437 no 2708 0.183158983599268 3989 1005053 YMR079W SEC14 SGTC_1333 1482-0047 286 µM -0.903863777143537 0.195737655857699 no 2709 0.183033819268056 3956 3811116 SGTC_2418 pentamidine 31.67 µM -0.905186408529394 0.195396274284273 no 2710 0.182683320519107 3946 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_612 0302-0167 22.4 µM -0.906246055017213 0.195123032307351 no 2711 0.182402815633707 3995 235821 SGTC_3046 9092212 49.47 µM -0.906474596384419 0.195064130760741 no 2712 0.182342352478272 4027 25236637 SGTC_1897 st060201 15 µM -0.906546518718005 0.195045596586082 no 2713 0.182323327217549 4018 611878 SGTC_2767 sibutramine 71.45 µM -0.906905393449728 0.194953131618366 no 2714 0.182228414388916 3948 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1896 st058441 89 µM -0.907005944970671 0.194927229049679 no 2715 0.182201826723127 3989 688759 SGTC_187 1488-2104 32.728 µM -0.909820017116239 0.19420315925703 no 2716 0.181458718112536 3983 2852859 SGTC_2375 9072683 200 µM -0.910082729088899 0.194135646327457 no 2717 0.181389441041466 4003 16798029 SGTC_1838 st055369 84.5 µM -0.910940488615327 0.19391531490608 no 2718 0.181163365419312 3981 676036 SGTC_2495 cafestol 54.53 µM -0.911262328309523 0.193832683752865 no 2719 0.181078585208264 4007 16667697 An anti-infammatory. SGTC_453 enantio-paf c16 10 µM -0.912582000276367 0.193494087336478 no 2720 0.18073121228404 3853 13871343 A lipid and platelet activating factor SGTC_2776 terbinafine 19.92 µM -0.913882743911093 0.193160700794996 no 2721 0.180389230942392 4004 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_226 1,3-diallylurea 8.28947 mM -0.914896889186726 0.192901014153093 no 2722 0.180122881661043 3955 74537 YKL182W FAS1 SGTC_2445 5742597 35.57 µM -0.918496833803164 0.191980919267405 no 2723 0.179179407901456 3958 1774255 SGTC_3109 9122853 49.47 µM -0.919906405529931 0.191621385653575 no 2724 0.178810835620138 4054 1234709 SGTC_867 0518-0118 155 µM -0.920979347324546 0.191347991469231 no 2725 0.17853060485897 3973 6848158 SGTC_2529 gangaleoidin 93.61 µM -0.924478091297758 0.190458145442555 no 2726 0.177618726534913 4024 4565183 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.925926987914242 0.190090388484277 no 2727 0.177241962467318 4007 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_633 0437-0093 97.7 µM -0.926389520011238 0.189973081172234 no 2728 0.177121794215014 3948 2831118 SGTC_2961 9083290 32.55 µM -0.92828068980293 0.189493906115424 no 2729 0.176630994024247 3930 17741490 SGTC_781 4335-2806 94.4 µM -0.929179182137733 0.189266511504438 no 2730 0.176398117123665 4096 845254 SGTC_2228 7354201 200 µM -0.929721259239016 0.189129401402523 no 2731 0.176257712158783 4016 753451 SGTC_961 1252-1571 372 µM -0.931235344794533 0.188746760789521 no 2732 0.175865919228675 4018 6813498 SGTC_115 0527-0192 112.043 µM -0.935460288712423 0.187681556230173 no 2733 0.17477556973169 4017 4233931 SGTC_2799 7812892 81.82 µM -0.937490369172349 0.187171050278496 no 2734 0.174253187726215 4051 20205235 SGTC_3091 9116372 49.47 µM -0.940702981225482 0.186364928954182 no 2735 0.173428545405008 4096 17169793 SGTC_1756 st041558 35.5 µM -0.941311913834274 0.186212376004548 no 2736 0.173272519576694 4117 3955792 SGTC_1915 st067105 30.6 µM -0.943619362343377 0.185635004580624 no 2737 0.172682097093377 3978 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2223 6903751 107.57 µM -0.944411469304632 0.185437059385671 no 2738 0.172479711380559 3984 5598863 SGTC_1548 st061468 90.8 µM -0.94459246208986 0.185391848217785 no 2739 0.172433488420071 4009 390799 SGTC_403 arphamenine a 50 µM -0.9454717074536 0.185172314136596 no 2740 0.172209054203767 3990 5487158 An arginine aminopeptidase inhibitor. SGTC_1624 st003710 6.25 µM -0.945566445925824 0.18514866903296 no 2741 0.172184882601697 4065 24207033 SGTC_455 paf C-16 10 µM -0.946204129132187 0.184989563000302 no 2742 0.172022240255535 3990 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2735 sertaconazole 140 nM -0.946272415932894 0.184972530044523 no 2743 0.172004829388982 4141 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1129 3453-1384 223 µM -0.948212219108829 0.184489086930042 no 2744 0.171510713917485 4150 1084452 SGTC_3036 9090181 49.47 µM -0.949292456820572 0.184220208103228 no 2745 0.171235944473118 4052 25236586 SGTC_1770 st043884 66.3 µM -0.94978942050557 0.18409659226651 no 2746 0.171109631287424 4032 670149 SGTC_984 1492-0255 2.91 µM -0.949952636892119 0.184056004731572 no 2747 0.171068159605694 3995 1585198 SGTC_2774 tamoxifen 10.92 µM -0.950331139644483 0.183961902696688 no 2748 0.170972010515761 4029 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1839 st053978 48 µM -0.950541899844012 0.183909517218159 no 2749 0.170918487183833 4043 3788398 SGTC_1908 st060353 56.5 µM -0.951702293286005 0.183621262159249 no 2750 0.170623993003746 4096 4227716 SGTC_658 3253-0951 102 µM -0.952276126700481 0.183478819442594 no 2751 0.17047848095782 4045 1184878 SGTC_1423 4048-0112 5.59 µM -0.953442055055129 0.18318961316532 no 2752 0.170183070976806 4065 X1423 SGTC_988 1497-1057 103 µM -0.953453917653516 0.183186672132579 no 2753 0.170180067049925 3963 3533044 SGTC_666 0272-0154 136 µM -0.953850022091015 0.183088484915497 no 2754 0.170079782330573 4047 6870312 SGTC_599 1935-0052 86.5 µM -0.954228627667128 0.182994666047907 no 2755 0.169983963338115 4032 9557311 SGTC_1392 3455-1037 33.9 µM -0.954434223873023 0.182943731657705 no 2756 0.169931944739977 4054 981132 SGTC_1467 k284-1082 293 µM -0.954912576832806 0.182825258769626 no 2757 0.16981095452373 4006 3334705 SGTC_2147 5545932 89.7195 µM -0.955392151068989 0.182706531494669 no 2758 0.169689710874725 4058 797404 SGTC_702 1488-0190 94 µM -0.957590580592563 0.182162886858121 no 2759 0.169134625397609 4089 949357 SGTC_3309 9129340 25.759 µM -0.957717074469859 0.182131637268216 no 2760 0.169102722241381 4049 17158987 SGTC_985 1493-0307 8.71 µM -0.959607613180634 0.181664989859166 no 2761 0.168626367986868 4056 3278274 SGTC_1326 1431-2094 10.8 µM -0.961560444543914 0.181183752831614 no 2762 0.168135224560491 4037 616278 SGTC_2313 7726885 200 µM -0.962664846359774 0.180911948456705 no 2763 0.167857871795435 4096 726423 SGTC_866 0495-0101 262 µM -0.96500803586221 0.18033611278968 no 2764 0.167270393428305 4017 635694 SGTC_1259 0671-0132 43 µM -0.965489710058739 0.180217884664304 no 2765 0.167149793737866 3962 X1259 SGTC_2213 7173844 200 µM -0.967364191896171 0.179758251633254 no 2766 0.166681002063717 3998 892728 SGTC_2848 9016370 25.97 µM -0.968944095192092 0.179371423326927 no 2767 0.166286541505357 4037 7894410 SGTC_2108 5365811 200 µM -0.969734028797288 0.17917821000394 no 2768 0.166089541992772 4075 780283 SGTC_1405 3909-7894 12 µM -0.969908018877255 0.17913567060657 no 2769 0.166046171325492 4056 7104060 SGTC_2695 st077686 51.995 µM -0.971113126425158 0.178841204382066 no 2770 0.165745973951756 4092 2876092 SGTC_1926 methyl fluorone black 53.6 µM -0.971355521631776 0.178782012301923 no 2771 0.165685634696579 3791 72721 Reacts with homocysteine. SGTC_3220 9131269 49.47 µM -0.972403008418768 0.178526361440034 no 2772 0.16542504793875 4076 17722206 SGTC_3154 9100113 49.47 µM -0.972725331833462 0.178447741157039 no 2773 0.16534491585108 4087 25237525 SGTC_75 0159-0059 199.013 µM -0.974729736139112 0.177959321780342 no 2774 0.164847169309868 4168 5377270 SGTC_837 0091-0265 12.5 µM -0.983701367951763 0.175783521623112 no 2775 0.162631183515056 4013 759367 SGTC_1293 1000-1278 195 µM -0.984709712982059 0.175540035573859 no 2776 0.162383340169719 4127 678847 SGTC_3058 9093861 49.47 µM -0.985770173811629 0.175284195795209 no 2777 0.162122952533331 4084 17217477 SGTC_2987 9018338 71.43 µM -0.986720321886368 0.175055170276939 no 2778 0.16188988238783 4106 5055682 SGTC_145 3737-0113 38.366 µM -0.986952411643007 0.174999255778505 no 2779 0.161832984248593 4028 6849351 SGTC_2895 9054447 58.44 µM -0.989952212142726 0.174277571154097 no 2780 0.161098738678303 4133 2697450 SGTC_2279 7948423 32.93 µM -0.99307299036253 0.173528792113682 no 2781 0.160337192722291 4026 1247112 SGTC_195 4234-0266 16.654 µM -0.995873434577519 0.172858617550665 no 2782 0.159655822155004 4081 2303354 SGTC_76 0433-0009 400.328 µM -0.998394929532377 0.172256611490367 no 2783 0.159043945683963 4174 2841569 SGTC_3247 9135149 49.47 µM -1.00229570642975 0.171327941320479 no 2784 0.158100397808092 4082 8934436 YOR116C RPO31 SGTC_1041 0206-0046 107 µM -1.0025062951946 0.171277897019461 no 2785 0.158049563838006 4099 50494 SGTC_2733 amorolfine 100 µM -1.00284708070236 0.171196932573537 no 2786 0.157967324441258 4197 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.00473259216142 0.170749411693774 no 2787 0.157512814928209 4150 23847180 SGTC_3062 9077494 49.47 µM -1.0047804146967 0.170738070893175 no 2788 0.157501298314893 4078 16459633 SGTC_3198 9112019 49.47 µM -1.00483264629255 0.170725685063612 no 2789 0.157488720544752 4138 45595555 SGTC_1547 harmine 94.2 µM -1.00646053120984 0.170339948295486 no 2790 0.15709704422188 4061 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3326 9140064 16.379 µM -1.00712590158847 0.170182445777533 no 2791 0.156937137761331 4025 1868434 SGTC_2889 9059656 51.95 µM -1.0071415990404 0.170178731097175 no 2792 0.156933366533349 4177 3949838 SGTC_2338 7999974 200 µM -1.00715578634947 0.170175373825121 no 2793 0.15692995816032 4101 315925 SGTC_2239 6685329 187.64 µM -1.00716777036367 0.170172537971849 no 2794 0.156927079146953 4148 805680 SGTC_2106 5357045 167.29 µM -1.00799582045663 0.169976664562478 no 2795 0.156728234354834 4119 668842 SGTC_2656 pseudo-anisatin 100 µM -1.00953289132423 0.169613457160761 no 2796 0.156359567812602 4132 6708809 A neurotoxin. SGTC_3110 9122132 49.47 µM -1.01004937954288 0.169491523654436 no 2797 0.156235816392525 4199 918317 SGTC_972 1319-0219 195 µM -1.01013219098983 0.169471978606291 no 2798 0.156215980638472 4087 23903702 SGTC_642 0335-0876 158 µM -1.01029298055862 0.169434033395431 no 2799 0.156177471590862 4131 6812350 SGTC_1822 st052468 42 µM -1.01109709642473 0.16924434951198 no 2800 0.155984979973264 4103 2873678 SGTC_3352 9151559 45.5865 µM -1.01192022753264 0.169050321358403 no 2801 0.155788098463663 4112 17159339 SGTC_3169 9102970 49.47 µM -1.01243251142436 0.16892963814453 no 2802 0.155665650039634 4169 17027839 SGTC_693 4161-2696 114 µM -1.01330585551662 0.168724024446038 no 2803 0.15545704575056 4132 805759 SGTC_1047 2043-3044 82 µM -1.01437435564194 0.168472683505898 no 2804 0.155202078073541 4104 669592 SGTC_1568 digitonin 820 nM -1.01567718976647 0.16816654659692 no 2805 0.154891566841244 4112 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2846 9008642 19.48 µM -1.01606107438518 0.168076410598396 no 2806 0.154800151943923 4178 2992898 SGTC_3099 9120367 49.47 µM -1.01633274485213 0.16801264123983 no 2807 0.154735480276378 4138 24824940 SGTC_2749 bexarotene 57.39 µM -1.02189654316203 0.16671007364455 no 2808 0.153414934375938 4159 82146 An retinoic acid receptor inhibitor. SGTC_845 0330-0138 4.51 µM -1.02589783482929 0.165777351278932 no 2809 0.152469871673543 4087 9039800 SGTC_2436 5633522 8.09 µM -1.02925671395499 0.164996988501325 no 2810 0.151679529036336 4111 5724242 SGTC_2817 7995342 71.43 µM -1.02949409080436 0.164941929265393 no 2811 0.151623777578056 4118 18879975 SGTC_744 1594-0068 283 µM -1.03034279458225 0.164745170911064 no 2812 0.151424558385704 4095 668392 SGTC_1725 st036284 20.55 µM -1.03229534259445 0.164293081534395 no 2813 0.150966891114589 4205 707914 SGTC_1426 4048-4480 71.7 µM -1.03356115120952 0.164000428731698 no 2814 0.150670684418571 4123 14224343 SGTC_2635 hydroquinidine 100 µM -1.03464815430493 0.163749385552151 no 2815 0.150416628349112 4054 442912 An experimental heart treatment. SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.03613941329277 0.163405385606724 no 2816 0.150068553573149 4222 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2514 salinomycin 42.74 µM -1.03647401543409 0.163328264934769 no 2817 0.149990527904937 4179 23682228 A polyether potassium ionophore. SGTC_1002 4049-0206 172 µM -1.03931414191837 0.162674611607044 no 2818 0.149329329931901 4108 4662749 SGTC_1286 0929-0070 131 µM -1.04127413962287 0.162224513137407 no 2819 0.148874167607915 4208 1420408 SGTC_820 1582-0060 59.9 µM -1.04341525677798 0.161733749551079 no 2820 0.148378005226376 4155 3848840 SGTC_2923 7992654 58.14 µM -1.04385743953057 0.161632517900803 no 2821 0.14827567589839 4146 2985126 SGTC_1342 1486-1464 234 µM -1.04506887349236 0.161355388410517 no 2822 0.147995569406508 4171 3253938 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.04598856835777 0.161145204665158 no 2823 0.147783155180635 4089 5711223 A potent inhibitor of glutathione S-transferases. SGTC_596 1155-0152 116 µM -1.04669185707823 0.160984598186852 no 2824 0.14762086028018 4135 280313 SGTC_3156 9099931 49.47 µM -1.04680872212619 0.160957920434585 no 2825 0.147593903409264 4171 18111053 SGTC_207 4185-0010 4.486 µM -1.04690420306501 0.160936126352016 no 2826 0.14757188158719 4190 3761753 SGTC_475 α-linolenic acid 10 µM -1.04795228764223 0.160697021545049 no 2827 0.147330294970088 4169 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1696 st025591 34.7925 µM -1.04985160987575 0.160264311050252 no 2828 0.146893171272835 4158 2787147 SGTC_1607 st000305 50.6 µM -1.05014833954723 0.160196777864626 no 2829 0.146824958418913 4160 5457690 SGTC_2161 5662504 8.5105 µM -1.05030212049577 0.160161785929611 no 2830 0.146789615285499 4110 2859334 SGTC_1883 5-benzylidenerhodanine 20 µM -1.05120068325865 0.159957423253692 no 2831 0.146583214720138 4122 1273210 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.05177563722459 0.1598267493547 no 2832 0.146451249583537 4185 279621 SGTC_2258 7960471 200 µM -1.05695235654184 0.158653345238487 no 2833 0.145266665899076 4197 2974708 SGTC_36 0335-0881 14.2 µM -1.06000790102635 0.157963404366718 no 2834 0.144570502427876 4053 23828853 SGTC_2135 5326629 150.42 µM -1.06004970918581 0.15795397778105 no 2835 0.144560992631584 4110 5020077 SGTC_880 0833-0487 87.2 µM -1.06120129713065 0.157694471697948 no 2836 0.144299215019306 4148 76075 SGTC_2317 5986382 200 µM -1.06184569720211 0.157549380805433 no 2837 0.144152870265781 4175 877883 SGTC_1000 4048-0884 8.67 µM -1.06191631808635 0.157533485386393 no 2838 0.144136838185362 4190 13040088 SGTC_1356 1502-0781 85.8 µM -1.06288992692365 0.157314451955142 no 2839 0.143915935803458 4143 567702 SGTC_2271 7849410 118.62 µM -1.06469749584463 0.156908333107808 no 2840 0.143506421824897 4103 972430 SGTC_2680 butyl paraben 22.24 µM -1.06583599238292 0.156652893687201 no 2841 0.143248893760807 4231 7184 An antifungal and steroid mimetic. SGTC_70 0141-0289 43.283 µM -1.06745278957781 0.15629061071437 no 2842 0.142883710692626 4129 352408 SGTC_2673 kobusone 100 µM -1.06761687848725 0.156253873452129 no 2843 0.142846683426347 4236 6710676 An epoxy ketone and protein crosslinker. SGTC_1035 k081-0041 55.2 µM -1.06833189663571 0.156093857076773 no 2844 0.142685412657186 4187 731709 SGTC_2214 7179297 48.276 µM -1.06844866265708 0.156067735867285 no 2845 0.142659088035495 4195 769744 SGTC_2333 9017922 200 µM -1.06851382865859 0.156053159122218 no 2846 0.142644397943328 4199 3163164 SGTC_1798 st045719 60.953 µM -1.06966997125059 0.155794694975958 no 2847 0.142383943719733 4079 3980186 SGTC_2622 2-methoxyxanthone 59.94 µM -1.07285692144498 0.155083691115964 no 2848 0.141667658434924 4162 71034 A hepatoprotective. SGTC_1104 tacrolimus 29.8 µM -1.07288023926856 0.155078496851765 no 2849 0.141662426631716 4220 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_293 4049-0273 38.5 µM -1.07334037464419 0.15497602087408 no 2850 0.141559213164201 4031 1380311 SGTC_433 pimozide 108 µM -1.07663501950055 0.154243582759773 no 2851 0.140821676411401 4066 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2356 9061756 188.97 µM -1.07728926865158 0.154098408405015 no 2852 0.140675527508693 4195 20104043 SGTC_773 4358-1457 44.6 µM -1.07909479223526 0.153698241538623 no 2853 0.140272736288216 4185 1186886 SGTC_1636 st007707 68.9 µM -1.07915855461961 0.153684122163319 no 2854 0.140258525978923 4220 403051 SGTC_1050 3232-1156 69.3 µM -1.08084375363118 0.153311267380633 no 2855 0.139883310983206 4154 700529 SGTC_98 0074-0023 107.663 µM -1.08408209819064 0.152596458746672 no 2856 0.139164199723081 4192 3563821 SGTC_2141 5621638 7.665 µM -1.08449169703394 0.152506204655228 no 2857 0.139073423201471 4198 2856238 SGTC_2051 5263410 176 µM -1.08688654981955 0.151979213905781 no 2858 0.138543475612083 4173 227584 SGTC_3273 9137859 49.47 µM -1.0887052842563 0.151579807892569 no 2859 0.138141935398285 4259 2377234 SGTC_838 0109-0203 71.4 µM -1.09038597884404 0.151211337218422 no 2860 0.137771577778338 4195 759422 SGTC_62 0180-0423 3.232 µM -1.09137946461048 0.150993808680433 no 2861 0.137552972296263 4142 30102 YGL099W LSG1 SGTC_2872 9044037 25.97 µM -1.09144176253111 0.150980175190328 no 2862 0.137539272226136 4193 6465195 SGTC_2813 7971799 71.43 µM -1.09181197887107 0.150899172680623 no 2863 0.137457876367676 4214 2234054 SGTC_2316 5844804 197.44 µM -1.09366318642808 0.150494566623926 no 2864 0.137051362834292 4200 776813 SGTC_2811 7967822 32.47 µM -1.09747699774663 0.149663287402816 no 2865 0.136216465312424 4241 2232244 SGTC_2940 9060638 45.86 µM -1.09755232862016 0.149646898786286 no 2866 0.136200009441531 4178 4027022 SGTC_113 0099-0221 2.5 µM -1.09801923562444 0.149545347492896 no 2867 0.136098044936741 4150 89219 SGTC_2266 7929956 200 µM -1.10022568374385 0.149066071961422 no 2868 0.135616901354121 4133 2967153 SGTC_1848 st056003 16.4 µM -1.1004072808821 0.149026671930527 no 2869 0.135577353794289 4203 146492 SGTC_1034 k072-0165 12.7 µM -1.10053666665048 0.148998604128653 no 2870 0.135549181456169 4222 5835461 SGTC_213 1246-0773 967 nM -1.1036940483086 0.148314764328912 no 2871 0.134862939137701 4205 6251622 SGTC_3259 9138485 49.47 µM -1.1041571401583 0.148214642657512 no 2872 0.134762489044022 4215 17646153 SGTC_1712 st032288 53.4 µM -1.10540803396445 0.14794442223144 no 2873 0.13449141206973 4062 2883011 SGTC_424 splitomicin 100 mM -1.10665390940619 0.147675613884038 no 2874 0.134221794929397 4256 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2984 9022109 38.96 µM -1.10759656174205 0.147472446044187 no 2875 0.134018044498418 4222 6459207 SGTC_966 1300-0360 30.2 µM -1.10828029070375 0.147325200638643 no 2876 0.1338703923325 4180 70588 SGTC_3222 9128301 49.47 µM -1.10994453007085 0.146967207965236 no 2877 0.133511465059652 4203 4911358 SGTC_1701 st028638 40.4 µM -1.11066500017105 0.146812409545136 no 2878 0.133356286406837 4216 3490878 SGTC_1173 0443-0020 122 µM -1.11543496046008 0.145790307583905 no 2879 0.132332037527171 4196 5331295 SGTC_129 0088-0017 176.636 µM -1.11555370069619 0.145764925216089 no 2880 0.13230660990975 4085 182446 SGTC_2326 6164455 177.58 µM -1.11585717727352 0.145700066398481 no 2881 0.1322416372484 4173 2888790 SGTC_712 r015-0009 80.6 µM -1.11811821347618 0.145217449995508 no 2882 0.131758254273732 4239 6813872 YLR060W FRS1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.11995750620377 0.144825648704861 no 2883 0.131365935375095 4340 16725076 SGTC_441 propafenone 146 µM -1.12177334207384 0.144439543013295 no 2884 0.130979411736175 4192 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1330 1469-0054 61.8 µM -1.12260476264466 0.144262987715873 no 2885 0.130802695880311 4211 7102664 SGTC_1408 3909-7976 48.8 µM -1.12380677397507 0.144007993365902 no 2886 0.130547503568491 4266 24152374 SGTC_17 0960-0276 49.807 µM -1.12436388567125 0.143889910999947 no 2887 0.130429343134941 4202 6821114 SGTC_570 0987-0065 62.6 µM -1.12518121445179 0.143716792666439 no 2888 0.130256125940275 3998 3104428 SGTC_2624 nerol 100 µM -1.1336584240347 0.14192952502893 no 2889 0.128468927878255 4136 637566 A natural product oil. SGTC_2553 4-methylesculetin 85.09 µM -1.13379680776171 0.141900474685526 no 2890 0.128439895178563 4251 5319502 SGTC_1215 3852-0577 11.2 µM -1.13472920224341 0.141704845787374 no 2891 0.128244398931296 4276 2884876 SGTC_156 3474-0145 5.642 µM -1.13621227905538 0.141394052875372 no 2892 0.127933866381029 4062 2265471 SGTC_1710 st031758 61.5 µM -1.13721737400115 0.141183688456484 no 2893 0.127723712827644 4263 5394341 SGTC_1881 5652484 16 µM -1.14089965764641 0.14041480711245 no 2894 0.126955840961641 4218 2255129 SGTC_2693 st077581 40.7 µM -1.14174945781937 0.140237768645463 no 2895 0.126779088216818 4262 25238761 SGTC_704 1310-0270 142 µM -1.14372056673383 0.139827712332957 no 2896 0.126369770599032 4251 5718033 SGTC_2128 5255449 168.493 µM -1.14582839374176 0.139390116706477 no 2897 0.12593308212766 4186 736008 SGTC_1831 st055328 12 µM -1.14646692119126 0.139257739210996 no 2898 0.125801003301674 4230 1103068 SGTC_2824 7998404 51.95 µM -1.15005872159784 0.138514692761451 no 2899 0.125059843138713 4208 837851 SGTC_68 0986-0284 82.829 µM -1.15152062717378 0.138213038960604 no 2900 0.124759057119887 4282 423278 YIL048W NEO1 SGTC_619 1652-1634 108 µM -1.15168880374383 0.138178365671461 no 2901 0.124724487363861 4211 5400454 SGTC_2244 6635614 200 µM -1.15593159688075 0.137305582719132 no 2902 0.123854568614154 4167 836499 SGTC_2925 9010536 32.5 µM -1.1574279373855 0.136998671210461 no 2903 0.123548782709453 4163 2994177 SGTC_2598 perillyl alcohol 100 µM -1.15783190776906 0.136915894049733 no 2904 0.123466319725151 4288 10819 An apoptosis inducer. SGTC_1495 4469-0029 237 µM -1.15990918164912 0.136490781824658 no 2905 0.123042892042973 4258 793680 SGTC_1695 st026914 34.495 µM -1.16225298451261 0.136012209716996 no 2906 0.122566359055075 4224 3289191 SGTC_3211 9128781 49.47 µM -1.1623692020927 0.135988509624442 no 2907 0.122542763884539 4240 17194361 SGTC_1842 st055362 61.2 µM -1.16322187061093 0.135814712563562 no 2908 0.122369747618617 4218 676032 SGTC_2528 xanthyletin 44.79 µM -1.16618894378812 0.135211128186335 no 2909 0.12176903086088 4283 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3161 9100388 49.47 µM -1.16639426177422 0.135169428995237 no 2910 0.121727538748538 4333 25236368 SGTC_509 pifithrin 175 µM -1.16856916999983 0.134728255970578 no 2911 0.121288627815097 4336 4817 A p53 inhibitor. SGTC_48 0382-0018 55 µM -1.16904038298185 0.134632802334314 no 2912 0.121193680766755 4332 762596 SGTC_2202 7226349 200 µM -1.16945819595687 0.134548204771847 no 2913 0.121109537287909 4220 844334 SGTC_1616 st002734 56.1 µM -1.17313826531775 0.133804651069659 no 2914 0.120370181845268 4193 4026101 SGTC_103 0844-0104 51.839 µM -1.17418425064844 0.133593827434713 no 2915 0.120160616473015 4123 5375804 SGTC_834 0312-0008 75.7 µM -1.17480125574412 0.133469574101773 no 2916 0.12003711882125 4277 6385573 YIL048W NEO1 SGTC_387 norethindrone acetate 66.7 µM -1.17530140553386 0.133368911599093 no 2917 0.119937076201871 4272 541197 SGTC_338 4055-0136 114 µM -1.17542146064211 0.133344756517401 no 2918 0.119913070891037 4253 2900563 SGTC_1709 st033179 39.1045 µM -1.17575155479201 0.133278357106027 no 2919 0.119847085223068 4255 573381 SGTC_1289 0976-0073 69.1 µM -1.17639218358841 0.133149557661828 no 2920 0.119719096886271 4328 3391136 SGTC_3193 9111931 49.47 µM -1.17661972929661 0.13310382985679 no 2921 0.119673659762814 4273 17087244 SGTC_1349 flufenamic acid 69 µM -1.1777290276761 0.132881058980419 no 2922 0.119452325351366 4199 3371 A non-steroidal anti-inflammatory. SGTC_681 1642-0006 26.6 µM -1.18076044070683 0.132273596167543 no 2923 0.118848951686395 4277 4446530 SGTC_2754 granisetron 64.02 µM -1.18178021067941 0.132069676110413 no 2924 0.118646460966765 4266 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3102 9121669 49.47 µM -1.18218936004908 0.131987920821902 no 2925 0.11856528674348 4310 41905072 SGTC_2058 5236698 133 µM -1.18271269922542 0.131883399273053 no 2926 0.118461514759837 4233 766665 SGTC_960 1222-0186 7.7 µM -1.18527244294609 0.131372988735591 no 2927 0.117954872680862 4280 3126296 SGTC_2893 9048488 25.97 µM -1.18541200043839 0.131345200361488 no 2928 0.117927294634807 4323 6467338 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.18547415436381 0.131332825717989 no 2929 0.117915013825827 4209 1241132 A phosphatase inhibitor. SGTC_1298 1079-1278 263 µM -1.18583409189347 0.131261179162082 no 2930 0.11784391263347 4250 2840950 SGTC_1655 st012546 55.1 µM -1.18748701606598 0.130932506681251 no 2931 0.117517787516477 4257 720985 YLR208W SEC13 SGTC_3146 9095609 49.47 µM -1.18785761118197 0.13085889453224 no 2932 0.117444756163485 4323 17173999 SGTC_3147 9097027 49.47 µM -1.18862151057151 0.130707249717559 no 2933 0.117294319682597 4265 25236841 SGTC_1642 st009582 77.7 µM -1.18913817036532 0.130604754348011 no 2934 0.117192650071135 4255 6739311 SGTC_632 0781-2353 4.65 µM -1.18956230374412 0.130520655985654 no 2935 0.117109234711965 4348 6811515 YHR007C ERG11 SGTC_1572 epiandrosterone 68.9 µM -1.19041524630792 0.130351645527106 no 2936 0.116941611772679 4199 441302 A steroid. SGTC_2973 9094665 17.96 µM -1.19193915707013 0.13005005980784 no 2937 0.116642551502982 4293 25237061 YIL048W NEO1 SGTC_1455 4262-0120 131 µM -1.19217482262675 0.130003464161728 no 2938 0.116596351715356 4335 1529587 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.1924307125879 0.129952882846564 no 2939 0.116546201839652 4266 641818 YHR062C RPP1 SGTC_870 0573-2213 57.6 µM -1.19659359230156 0.129131927058592 no 2940 0.11573249961111 4271 3916321 SGTC_1660 st012960 28.1 µM -1.19803011614901 0.128849468427369 no 2941 0.115452646420811 4304 24207266 SGTC_174 3553-0389 74.3 µM -1.2010517924384 0.128256726460145 no 2942 0.114865555673861 4349 738071 SGTC_3023 9089636 49.47 µM -1.2012577230145 0.128216399471454 no 2943 0.114825622228821 4358 17249241 SGTC_84 0443-0269 128.823 µM -1.20131940074988 0.128204322952939 no 2944 0.114813663787981 4210 6150058 SGTC_1130 3454-2858 15.9 µM -1.20213749117974 0.128044215333397 no 2945 0.114655131428902 4284 715628 YIL048W NEO1 SGTC_2302 7771753 200 µM -1.20214317655018 0.128043103141733 no 2946 0.114654030243694 4293 2203047 SGTC_1937 st074714 47.2 µM -1.202366803089 0.127999361874439 no 2947 0.114610722547495 4227 17250970 SGTC_2751 anetholtrithion 17.25 µM -1.20311749003171 0.127852603708331 no 2948 0.114465429044864 4271 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1266 0828-0227 32.9 µM -1.203342626425 0.127808612684422 no 2949 0.114421880051341 4262 3913820 SGTC_2838 9002687 71.43 µM -1.20440752725782 0.127600676586924 no 2950 0.114216052055824 4277 6457060 SGTC_2047 4141938 200 µM -1.20526249189161 0.127433903637259 no 2951 0.114050992247239 4296 3807862 SGTC_502 l-744,832 89.3 µM -1.20595392346673 0.127299141037896 no 2952 0.113917628532176 4302 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2120 5538279 151.968 µM -1.20674251182971 0.127145563262831 no 2953 0.113765660842207 4250 2058197 SGTC_566 0958-0068 16.5 µM -1.20751662855692 0.12699492928186 no 2954 0.113616622552451 4197 6815365 SGTC_719 2810-4230 27.3 µM -1.20899506205188 0.126707588806495 no 2955 0.113332371233799 4296 721079 SGTC_369 0957-0393 4.5 µM -1.21052350927436 0.126411004220797 no 2956 0.113039037683324 4305 6997992 SGTC_271 rotenone 740 µM -1.21204539119973 0.126116174502497 no 2957 0.112747502860634 4338 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1146 3579-1023 7 µM -1.21210211919573 0.126105194029074 no 2958 0.112736646317865 4320 X1146 SGTC_2157 5649910 96.377 µM -1.21917939108215 0.124740517271548 no 2959 0.111388056121486 4281 2858091 SGTC_42 0133-0086 60.653 µM -1.21962498685148 0.124654941849172 no 2960 0.111303534885533 4173 162923 Model of phenazepam hydroxylation. SGTC_2304 7443016 91.4 µM -1.22210515896688 0.124179381557092 no 2961 0.110833931223111 4235 939854 SGTC_1028 k015-0029 4.8 µM -1.22469858161273 0.123683465049641 no 2962 0.110344404376678 4275 4588309 SGTC_177 1327-0068 8.361 µM -1.22593431586734 0.123447655321145 no 2963 0.110111696967589 4296 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1236 0330-0013 258 µM -1.22647841252167 0.123343927673926 no 2964 0.110009347065685 4317 4617066 SGTC_771 0250-0039 27.3 µM -1.22679029790669 0.123284496777216 no 2965 0.109950709161723 4273 3005115 SGTC_3092 9117248 49.47 µM -1.2307423697776 0.1225331527578 no 2966 0.109209617963922 4437 17141857 SGTC_1947 st076332 61.6 µM -1.23086785628628 0.122509348762526 no 2967 0.109186145708432 4189 24208416 SGTC_829 1635-0120 117 µM -1.23151133687014 0.122387335555228 no 2968 0.109065839597611 4320 285054 SGTC_1982 st072467 71.9 µM -1.23245583426282 0.122208399718827 no 2969 0.108889427515328 4287 3163533 SGTC_358 0075-0058 9.45 µM -1.23358557801406 0.121994610136099 no 2970 0.108678684894845 4236 1069125 SGTC_303 1348-1668 34.2 µM -1.23687344989508 0.121373917420222 no 2971 0.108067034103465 4325 5380509 SGTC_2677 mitomycin C 100 µM -1.23825843559119 0.121113122137559 no 2972 0.107810125120876 4380 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1605 st000082 49.1 µM -1.23985355518578 0.120813247001891 no 2973 0.107514782639424 4282 1114022 SGTC_3239 9133757 49.47 µM -1.24232624093196 0.120349427054964 no 2974 0.107058108669559 4356 17036923 SGTC_2802 7925815 54.55 µM -1.2460238471149 0.119658182370943 no 2975 0.106377820205176 4291 1262923 SGTC_462 ag-879 158 µM -1.25208228095362 0.118531656951428 no 2976 0.105269941767214 4358 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2294 7971431 200 µM -1.25329952525859 0.118306225678916 no 2977 0.105048360577121 4325 5741572 SGTC_3268 9137683 49.47 µM -1.25386091263649 0.118202360029242 no 2978 0.104946282194825 4404 1953228 SGTC_1650 st011916 45.8 µM -1.25452484135613 0.118079605834245 no 2979 0.104825651184526 4252 242528 SGTC_1720 st037298 9.481 µM -1.256835621299 0.11765306740008 no 2980 0.104406582195671 4325 597396 SGTC_2607 solasodine 47.35 µM -1.26532099951211 0.116096141325991 no 2981 0.102878140896655 4313 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1587 estradiol valerate 56.1 µM -1.26768738299082 0.115664568894358 no 2982 0.10245480612651 4390 13791 A steroid. SGTC_2442 5158906 48.48 µM -1.26809303798719 0.115590701578789 no 2983 0.102382363730102 4347 1893835 SGTC_2374 9071832 200 µM -1.26882651401208 0.11545722513661 no 2984 0.102251473204693 4267 17381698 SGTC_3074 9116018 49.47 µM -1.27020233135918 0.115207152230554 no 2985 0.102006283712753 4397 17027303 SGTC_1009 4106-0057 9.87 µM -1.27085421503904 0.115088798336894 no 2986 0.101890258609847 4348 2928005 SGTC_1801 st050089 28.441 µM -1.27321127677765 0.114661579356639 no 2987 0.101471540027598 4382 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.27458245203494 0.114413572758099 no 2988 0.101228535905121 4350 1377 SGTC_3014 9081533 49.47 µM -1.27600968868314 0.114155832130323 no 2989 0.100976047096279 4384 21367265 SGTC_3267 9137951 49.47 µM -1.27627483618425 0.114107995478535 no 2990 0.100929191136483 4398 16643986 SGTC_908 3448-7491 47.7 µM -1.27694741906142 0.113986715326152 no 2991 0.100810405697208 4348 1203031 SGTC_2026 5148700 152 µM -1.27922545578542 0.113576622098963 no 2992 0.100408837089185 4328 79838 SGTC_3209 9113616 49.47 µM -1.28184440986835 0.113106457914863 no 2993 0.0999486159530936 4403 16649353 SGTC_510 ag-490 170 µM -1.28238332911758 0.113009881713245 no 2994 0.0998541046694321 4482 5328779 SGTC_3340 9146634 11.102 µM -1.28292642975006 0.112912615747301 no 2995 0.0997589261448283 4351 4907387 SGTC_3053 9095903 49.47 µM -1.28357032657727 0.112797375247185 no 2996 0.0996461689504004 4475 17174018 SGTC_2471 5466956 24.79 µM -1.28426605732483 0.112672952259655 no 2997 0.0995244394654173 4345 724419 SGTC_460 trequinsin 123 µM -1.29013939601697 0.111626481988359 no 2998 0.098501131763709 4441 5537 A vasodilator. SGTC_624 k048-0052 28 µM -1.29050646374241 0.111561312079952 no 2999 0.0984374345253452 4333 6835531 SGTC_1194 1488-0194 225 µM -1.29333726131565 0.111059641260724 no 3000 0.0979472193541127 4319 1391452 SGTC_1085 doxorubicin 7.67 µM -1.29426323815675 0.110895891877222 no 3001 0.0977872549729866 4378 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2731 amoxapine 43.43 µM -1.29892732242535 0.110073726542303 no 3002 0.0969844360246052 4521 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2170 morpholine 200 µM -1.30011669968696 0.109864769613169 no 3003 0.0967804874415262 4404 121171 Reacts with secondary amines. SGTC_88 0180-0332 8.668 µM -1.30170424538125 0.10958630387445 no 3004 0.0965087538822068 4450 3101745 SGTC_430 0958-0115 16.4 µM -1.30388698236878 0.109204265697262 no 3005 0.0961360596738699 4303 6833180 SGTC_3355 9151058 44.0485 µM -1.30486179932941 0.109033955769335 no 3006 0.0959699555341278 4385 17015728 SGTC_2446 5162541 200 µM -1.30512939793892 0.108987237123623 no 3007 0.0959243949552319 4342 1549321 SGTC_1185 1319-0113 81.3 µM -1.30597830716091 0.108839125718893 no 3008 0.0957799673595336 4432 4672763 SGTC_2190 6049624 200 µM -1.30741516561857 0.108588763152468 no 3009 0.095535874742828 4263 2265554 SGTC_149 3970-0822 46.1 µM -1.30747810904744 0.10857780517769 no 3010 0.0955251924287841 4355 3114250 YBL034C STU1 SGTC_2386 9075165 157.42 µM -1.30885959780237 0.108337498721322 no 3011 0.0952909572487787 4362 16452277 SGTC_1459 k035-0031 35.7 µM -1.31431453405682 0.107392366010095 no 3012 0.0943701891087093 4107 3877128 YMR208W ERG12 SGTC_2245 6637752 200 µM -1.31480907888196 0.107306974981727 no 3013 0.0942870377208053 4409 681890 SGTC_709 3807-1509 243 µM -1.31556705116733 0.107176194034803 no 3014 0.0941596992732465 4445 1886677 YPL242C IQG1 SGTC_2482 5981709 142.65 µM -1.31785722410684 0.106781744721143 no 3015 0.0937757237482466 4312 877755 SGTC_3184 9108758 49.47 µM -1.31880228232967 0.106619277754998 no 3016 0.0936176105276911 4394 902885 SGTC_3088 9117578 49.47 µM -1.32364017575517 0.105790379455198 no 3017 0.0928112877844583 4441 678341 SGTC_802 4112-3352 742 µM -1.32588363404118 0.105407582455784 no 3018 0.0924391223749085 4423 704594 SGTC_2654 protoveratrine a 100 µM -1.33136399440468 0.104476694534449 no 3019 0.0915346353658906 4413 5702278 A heart drug and vasodilator. SGTC_1323 1348-1351 11.2 µM -1.33168844832128 0.104421770502159 no 3020 0.0914812933696109 4378 6989654 SGTC_850 0388-0143 75.9 µM -1.33610303486459 0.103676540897563 no 3021 0.0907577990929999 4377 67273 SGTC_1386 3228-0095 33.8 µM -1.33667118706456 0.103580911685359 no 3022 0.0906649954808825 4387 870181 SGTC_2438 5259590 200 µM -1.33704052595825 0.10351878031049 no 3023 0.090604704391923 4398 1201127 SGTC_2853 9015042 58.44 µM -1.33725653897314 0.103482454445335 no 3024 0.0905694561015025 4316 6457456 SGTC_690 glyoxal 20.3 µM -1.3411136572769 0.102835378314041 no 3025 0.0899417768905802 4196 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3032 9089427 49.47 µM -1.3414430680485 0.1027802524243 no 3026 0.089888321196369 4382 17173707 SGTC_3252 9135871 49.47 µM -1.34432845839404 0.10229830876872 no 3027 0.0894210984436605 4404 17682838 SGTC_3196 9111891 49.47 µM -1.34630081142585 0.101969815853151 no 3028 0.0891027621325718 4376 18891510 SGTC_1175 0741-0056 27.6 µM -1.34692244979141 0.101866442032244 no 3029 0.0890026051725328 4471 765927 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.34753368175213 0.101764873111855 no 3030 0.0889042066019722 4376 364106 SGTC_2250 alverine citrate 130 µM -1.34996610309602 0.101361406115436 no 3031 0.0885134280600399 4271 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1102 cgs 12066b 26.1 µM -1.35004794437069 0.101347851353504 no 3032 0.0885003022085518 4412 6438352 A 5-HT1B full agonist. SGTC_714 4296-0578 26.1 µM -1.352150698516 0.101000040522394 no 3033 0.0881635557856273 4455 1589775 SGTC_1182 1222-0449 220 µM -1.35584881794892 0.100390456892855 no 3034 0.0875736375302738 4398 658318 SGTC_172 1112-0046 2.638 µM -1.35603932136711 0.100359127922581 no 3035 0.0875433286894683 4379 2802135 YIL048W NEO1 SGTC_2227 7312221 64.1025 µM -1.35622914242865 0.100327918265553 no 3036 0.0875131361973652 4525 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2883 9059145 45.46 µM -1.35630978230945 0.100314661906983 no 3037 0.0875003121595258 4385 16476510 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.35688984906434 0.100219342628743 no 3038 0.0874081063498571 4448 91467 include heat shock SGTC_2869 9037858 32.47 µM -1.35697540084222 0.100205289957428 no 3039 0.0873945134148284 4376 27187042 SGTC_1282 0886-0010 32.4 µM -1.36208687991351 0.0993682905443432 no 3040 0.0865852341806082 4430 2836211 YNL267W PIK1 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.36405507124129 0.0990473678856059 no 3041 0.0862751168674815 4418 2346 DNA damaging agent; causes G2/M arrest. SGTC_3013 9080133 71.4286 µM -1.37178338934131 0.0977945625395916 no 3042 0.0850654398664811 4477 17050193 SGTC_228 caffeine 993.056 µM -1.37367279280064 0.0974900540054331 no 3043 0.0847716435222577 4400 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1470 k295-0292 231 µM -1.37480671041841 0.0973076387119224 no 3044 0.0845956885890153 4488 5045612 SGTC_1084 voriconazole 435 nM -1.376049572931 0.0971079850673466 no 3045 0.084403143045817 4434 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1012 4112-3522 18 µM -1.37642569087516 0.0970476247168253 no 3046 0.0843449393277028 4421 3112398 SGTC_1237 0330-0133 46.1 µM -1.37704909104845 0.0969476405518074 no 3047 0.0842485353749177 4345 X1237 YHR072W ERG7 SGTC_678 1218-2179 85.9 µM -1.38015682701501 0.0964503337021754 no 3048 0.0837691817772025 4466 6820081 YOR116C RPO31 SGTC_2172 5754775 163.918 µM -1.38127034362087 0.0962726031890827 no 3049 0.0835979265653121 4411 2263357 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.38225644222033 0.0961154111869398 no 3050 0.0834464875786265 4378 6708739 YPR165W RHO1 SGTC_1300 1094-0077 113 µM -1.38595037856492 0.0955282455502571 no 3051 0.0828810280132283 4397 5532636 SGTC_1274 0865-0114 173 µM -1.38857386597533 0.0951128380567539 no 3052 0.0824811844341519 4417 870624 SGTC_888 0916-0002 6.97 µM -1.39001518083677 0.0948851847871837 no 3053 0.0822621337833887 4449 2802138 YIL048W NEO1 SGTC_2779 methotrexate 400 µM -1.39009807718129 0.0948721036678982 no 3054 0.0822495485557409 4431 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2703 st077852 53.4 µM -1.3928834504101 0.0944333412875197 no 3055 0.0818275188712734 4456 6281836 SGTC_1481 3346-2004 36 µM -1.39325942408509 0.0943742313120779 no 3056 0.081770677945793 4513 2770522 SGTC_762 1165-0429 115 µM -1.39327056353633 0.0943724804017733 no 3057 0.0817689943013277 4421 5967793 SGTC_2497 7-hydroxyflavone 100 µM -1.3952257767791 0.0940655289754255 no 3058 0.0814738831176339 4444 5281894 SGTC_1155 4088-0394 48.2 µM -1.39937226927084 0.0934170045988757 no 3059 0.0808506890705164 4425 2326248 SGTC_2962 9082311 13.18 µM -1.40508178566215 0.0925294314903 no 3060 0.0799984798463495 4401 16459453 SGTC_3120 9124077 49.47 µM -1.40770510269102 0.0921237217623217 no 3061 0.079609205122686 4558 18774327 YGL155W CDC43 SGTC_261 5-fluorouridine 15.376 µM -1.41155085005864 0.0915313394711101 no 3062 0.0790411265188893 4459 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1160 4092-0570 10.5 µM -1.4126514824288 0.0913623235183898 no 3063 0.0788791118563421 4450 4994975 SGTC_2465 5809242 33.21 µM -1.41452511799809 0.0910751355308589 no 3064 0.0786038888644525 4504 2731748 SGTC_363 0455-0021 3.06 µM -1.4158303707204 0.0908754644466556 no 3065 0.0784125876027444 4398 4597466 SGTC_2653 dihydrofissinolide 100 µM -1.41774201146458 0.0905836175698435 no 3066 0.0781330498809498 4494 6857746 SGTC_2427 5545055 42.75 µM -1.42052009686394 0.0901607331562231 no 3067 0.0777281610319377 4371 5372858 SGTC_3280 9140961 49.47 µM -1.42128834952014 0.0900440478288799 no 3068 0.0776164745425191 4482 4901226 SGTC_1476 4112-3294 3.34 µM -1.4232138980367 0.0897520808279184 no 3069 0.0773370789574962 4452 704369 SGTC_2665 lovastatin 100 µM -1.42435790945994 0.0895789503028016 no 3070 0.0771714459520759 4474 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1602 st001878 87.6 µM -1.4255446678878 0.0893996131648615 no 3071 0.0769999088985598 4430 595405 YLR310C CDC25 SGTC_1686 st019653 115.5 µM -1.42764963455825 0.0890821780563124 no 3072 0.0766963648138191 4457 97252 SGTC_350 k064-0020 19.8 µM -1.42897196412353 0.0888831963689103 no 3073 0.0765061458299625 4471 2790705 SGTC_2564 betulinic acid 100 µM -1.43094887834671 0.0885863314450298 no 3074 0.0762224335378735 4475 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_24 0417-1663 219 µM -1.43106443556344 0.0885690015775765 no 3075 0.0762058744141642 4477 4329390 SGTC_2479 5617353 43.85 µM -1.43290535746455 0.0882932629634099 no 3076 0.0759424430117847 4469 2731746 SGTC_2483 5729050 27.16 µM -1.43325572703277 0.088240856142842 no 3077 0.0758923846250665 4447 2865180 SGTC_134 0269-0018 6.916 µM -1.43807351114571 0.0875225817048683 no 3078 0.0752065987678366 4407 4378915 SGTC_2132 5317594 122.667 µM -1.44369214191681 0.0866904325820541 no 3079 0.0744127964179889 4396 794577 SGTC_1769 st044406 64.4 µM -1.44657685504876 0.0862654952500073 no 3080 0.0740077362072699 4442 670903 SGTC_402 epigallocatechin gallate 10 µM -1.45204778447478 0.0854638731688782 no 3081 0.0732441595412795 4413 65064 An antioxidant. SGTC_521 r062-0005 13.8 µM -1.4527422081355 0.0853625238111249 no 3082 0.0731476715929446 4395 2832033 SGTC_275 trichlorophene 5.69 µM -1.45371581059593 0.0852205806565524 no 3083 0.0730125564530975 4506 62616 SGTC_1006 4099-6547 255 µM -1.45398299488448 0.085181658348338 no 3084 0.0729755104277918 4469 3146833 SGTC_2917 7979103 53.79 µM -1.45694822901072 0.0847505890959203 no 3085 0.0725653357655809 4466 2980565 SGTC_2197 6588183 93.1375 µM -1.45708500659845 0.0847307446715902 no 3086 0.0725464582999741 4477 884136 SGTC_3171 9103192 49.47 µM -1.46041275788617 0.0842490097629632 no 3087 0.0720883342942083 4558 13018434 SGTC_286 k060-0067 22.9 µM -1.46221238968796 0.0839893477691769 no 3088 0.0718415087547062 4498 5985051 SGTC_894 0960-0238 55.9 µM -1.46671994395366 0.0833416080914348 no 3089 0.0712261275917738 4473 6741907 YDL195W SEC31 SGTC_1446 4239-0190 62 µM -1.47631728982883 0.0819749810670622 no 3090 0.069929367381083 4481 1340085 SGTC_2100 5377183 190 µM -1.47732535405353 0.0818324221148122 no 3091 0.0697942224089491 4508 2844202 SGTC_401 neomycin 50 µM -1.4781208942694 0.081720049972195 no 3092 0.0696877112154537 4491 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2370 9071495 200 µM -1.48995652102361 0.0800619480439167 no 3093 0.0681178342646418 4488 21791103 SGTC_783 0848-0141 92.7 µM -1.49187258989396 0.079795927194163 no 3094 0.0678662747876138 4419 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3332 9141069 11.198 µM -1.4920645564611 0.0797693120616805 no 3095 0.0678411112108012 4433 17332883 SGTC_2989 9073649 71.4286 µM -1.49483589062187 0.0793858293088654 no 3096 0.0674786384948382 4470 21367202 SGTC_2155 5570423 76 µM -1.49655436616625 0.0791487375213557 no 3097 0.0672546258443036 4468 797402 SGTC_806 3966-4455 5.86 µM -1.49964452519679 0.0787237490993161 no 3098 0.0668532537865116 4470 714982 SGTC_2402 5553605 200 µM -1.49983899422447 0.0786970617941195 no 3099 0.0668280568680058 4538 6758546 SGTC_2403 6032726 181.2 µM -1.5020931641404 0.0783882184711441 no 3100 0.0665365250295771 4495 2881040 SGTC_1753 st043925 64 µM -1.50429048899367 0.0780880488502855 no 3101 0.0662532934656581 4521 670181 SGTC_1816 st051957 91.6 µM -1.5113760359295 0.0771260530172046 no 3102 0.0653463356832049 4507 674121 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.51696083545812 0.0763741792016984 no 3103 0.0646382862322791 4526 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1015 4130-4525 82 µM -1.52117753728232 0.0758101953701117 no 3104 0.0641076454060626 4520 1363237 SGTC_1391 3442-0225 151 µM -1.52120493569634 0.0758065412328191 no 3105 0.0641042086253043 4476 5227075 SGTC_1714 st033236 13.627 µM -1.52221164389399 0.0756723691631453 no 3106 0.0639780292460343 4512 2916566 SGTC_2383 9036125 200 µM -1.5286626260396 0.0748168854524544 no 3107 0.0631740510011952 4461 79580 SGTC_351 caspofungin 25 nM -1.53152425194611 0.0744397677240397 no 3108 0.0628199386640193 4499 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3000 9075062 71.4286 µM -1.53382066428807 0.0741381873078566 no 3109 0.0625368889177535 4492 17057871 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.53477926118577 0.0740125743259123 no 3110 0.062419029330046 4511 75037 A free radical scavenger. SGTC_574 1315-0397 40 µM -1.5357897485465 0.0738803378153402 no 3111 0.0622949773963655 4505 6794277 SGTC_2067 5224629 34.075 µM -1.54008447880089 0.0733203255428314 no 3112 0.0617698813133564 4480 2835000 SGTC_590 k048-0076 22.4 µM -1.54061123063529 0.0732518637767932 no 3113 0.0617057164820875 4529 6832814 SGTC_1864 st057645 30.4 µM -1.54453247352559 0.0727437572843711 no 3114 0.0612296953075385 4555 688666 SGTC_78 0336-0123 156.75 µM -1.54687308170597 0.0724417549373709 no 3115 0.0609469265856816 4371 6765896 SGTC_849 0386-0493 241 µM -1.54975292620023 0.0720714954795072 no 3116 0.060600414759945 4547 726119 SGTC_554 4483-2211 187 µM -1.55044694351747 0.0719824835047727 no 3117 0.060517139333589 4564 747107 SGTC_1152 3909-8331 15.9 µM -1.55659990915193 0.0711970104288854 no 3118 0.0597827526991166 4513 16001939 SGTC_1439 4092-1168 46 µM -1.55786082193713 0.0710368607895019 no 3119 0.0596331221087224 4542 2886240 SGTC_962 1254-0300 21.5 µM -1.55871762614467 0.0709281953040504 no 3120 0.0595316140402688 4509 7340576 SGTC_246 cycloheximide 667 µM -1.56145455423292 0.0705819355629863 no 3121 0.0592082693053986 4459 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_214 4373-3496 70 µM -1.56580982653963 0.0700336133206535 no 3122 0.0586965725320175 4592 3779166 SGTC_901 1112-0062 60.1 µM -1.56758325138225 0.0698112829960316 no 3123 0.0584892116783236 4523 1908457 SGTC_1385 3091-4834 14.1 µM -1.5710985851307 0.0693721795530875 no 3124 0.0580798756062878 4518 4072814 SGTC_2088 5278280 127.392 µM -1.57222317705632 0.0692321558404129 no 3125 0.0579494010681412 4565 791502 SGTC_306 1672-3436 11.6 µM -1.57664956152129 0.068683138096913 no 3126 0.0574380910396738 4545 6797378 SGTC_526 4469-0568 170 µM -1.57993035214003 0.0682783828929658 no 3127 0.0570614086908575 4503 2901964 SGTC_818 4072-2707 53.5 µM -1.58011017885864 0.068256250774655 no 3128 0.0570408183276279 4462 882871 SGTC_2134 5324836 1.464 µM -1.58503655091264 0.0676520900157594 no 3129 0.0564790149847051 4518 699272 SGTC_3279 9140807 49.47 µM -1.5861074637295 0.067521303653545 no 3130 0.0563574670258979 4594 45595718 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.59020931483412 0.0670221675009181 no 3131 0.0558938157825131 4523 688803 SGTC_1880 MG-132 525 µM -1.5921556832546 0.0667863231016483 no 3132 0.0556748640288321 4509 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3006 9075424 71.4286 µM -1.59432311429224 0.0665244484585913 no 3133 0.0554318415927513 4506 7465181 SGTC_1222 0366-0074 1.18 µM -1.60036168471322 0.0657990444321527 no 3134 0.0547591849360733 4558 286520 SGTC_3302 9125395 16.351 µM -1.60042203300089 0.0657918259541122 no 3135 0.0547524952497218 4506 17599668 SGTC_1113 artemisinin 1.17947 µM -1.60043854135795 0.0657898514364433 no 3136 0.0547506653893648 4574 2240 An anti-malaria and mitochondrial poison. SGTC_1114 scopoletin 1.73284 µM -1.60273376673616 0.065515772923281 no 3137 0.0544967225937342 4579 5280460 A coumarin with genotoxic properties. SGTC_789 1309-1135 70.6 µM -1.60489973681267 0.065257941952381 no 3138 0.0542579357468705 4535 3092424 SGTC_1953 st076800 12.1 µM -1.60606584428137 0.0651194581794584 no 3139 0.0541297217661962 4510 297591 SGTC_676 falcarinol 140 µM -1.60774497368744 0.0649204500676944 no 3140 0.0539455221788893 4562 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1062 mesoridazine 14.2 µM -1.60947029154292 0.0647164598835735 no 3141 0.05375677301047 4600 4078 A neuroleptic. SGTC_1071 trifluoperazine 6.31 µM -1.60991724951991 0.0646636957879909 no 3142 0.0537079613591173 4600 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2867 9039098 71.43 µM -1.61014888460663 0.0646363640474416 no 3143 0.0536826786314138 4531 6463460 SGTC_3243 9134147 49.47 µM -1.61138666888423 0.0644904639676945 no 3144 0.0535477355135318 4636 24282180 SGTC_583 1488-1091 88.9 µM -1.61488521569871 0.0640794667774764 no 3145 0.0531677772305188 4646 4303273 SGTC_469 w7 172 µM -1.61723641133601 0.0638044025564129 no 3146 0.0529136297269671 4651 45115570 A P450 inhibitor. SGTC_2109 5483026 200 µM -1.62206514581181 0.0632423740925773 no 3147 0.0523947000272773 4569 759335 SGTC_2322 7413319 38.22 µM -1.62407080748009 0.0630100662544847 no 3148 0.0521803487382376 4495 1840400 SGTC_409 arachidonic acid 100 µM -1.62876479597674 0.0624689785463909 no 3149 0.0516814099246898 4580 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_340 k038-0059 454 µM -1.63546144072594 0.0617033190366662 no 3150 0.0509761757880745 4550 23733424 SGTC_3349 9149703 23.001 µM -1.63960041673068 0.061233766211559 no 3151 0.0505441382016152 4574 4910494 SGTC_1475 4092-1048 11.7 µM -1.63973601201142 0.0612184307508612 no 3152 0.0505300338959997 4570 2881759 SGTC_2618 avocadyne 43.43 µM -1.64110977037146 0.0610632315597193 no 3153 0.0503873154814354 4507 3015189 SGTC_2979 9012552 45.46 µM -1.64544748340284 0.0605752001533355 no 3154 0.0499387821420778 4578 17100905 SGTC_1277 0873-0036 22 µM -1.65018347467103 0.0600458490514366 no 3155 0.04945270785017 4625 5965735 SGTC_2152 5568786 200 µM -1.65625893025997 0.0593720952850319 no 3156 0.0488346968730574 4602 5399883 SGTC_1434 4073-0095 163 µM -1.66310622226985 0.0586198665783205 no 3157 0.0481455872978646 4586 24133745 SGTC_305 1682-2595 20.8 µM -1.66940448331453 0.0579345784188534 no 3158 0.0475186228718738 4589 226033 SGTC_1180 1193-0155 285 µM -1.68241602671548 0.056538797996985 no 3159 0.0462440978831981 4629 2921347 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.68409308495862 0.0563608400267754 no 3160 0.0460818402786935 4666 4620898 SGTC_1238 0333-0287 48.8 µM -1.68457297930575 0.0563099982449974 no 3161 0.0460354941125901 4582 7226 SGTC_2359 9039622 200 µM -1.68888057228477 0.0558552531344209 no 3162 0.0456211595213864 4538 6463596 SGTC_3163 9099914 49.47 µM -1.69314185387087 0.0554082527556581 no 3163 0.0452142346211284 4674 16268368 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.69526767877474 0.0551863162374438 no 3164 0.0450123266268152 4564 97141 SGTC_5 0352-0601 109.883 µM -1.69609069801472 0.0551005816625444 no 3165 0.044934352493852 4503 762456 SGTC_1358 1509-0022 2.48 µM -1.69747828563551 0.0549562738412621 no 3166 0.0448031364958006 4605 3258434 SGTC_2762 leflunomide 42.06 µM -1.70452755722582 0.0542277634758246 no 3167 0.0441412861360635 4558 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3172 9105863 49.47 µM -1.70693292552558 0.0539809354950585 no 3168 0.0439172600705534 4699 2348785 SGTC_389 tpck 16.7 µM -1.70718178410481 0.0539554496067807 no 3169 0.0438941348494265 4618 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2087 5276107 200 µM -1.70808327696353 0.0538632064523603 no 3170 0.0438104457091673 4598 144405 SGTC_1089 terbinafine 2.25 µM -1.71696300239844 0.0529612677701914 no 3171 0.0429929660827856 4612 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2276 7947513 42.08 µM -1.71773947413531 0.0528829722791443 no 3172 0.0429220729109594 4526 2105100 SGTC_1428 4049-0204 61.7 µM -1.71977621932504 0.0526780334182375 no 3173 0.0427365634553909 4634 X1428 SGTC_470 aa-861 153 µM -1.72163207672908 0.0524918448399625 no 3174 0.0425680943391911 4549 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2039 Aminomethylbenzodioxan 200 µM -1.72569756057964 0.0520858014812592 no 3175 0.0422009185716712 4621 15053 SGTC_3319 9138450 16.7555 µM -1.7380259881207 0.0508697298609843 no 3176 0.0411031173351271 4556 2029690 SGTC_1665 st014639 11.4 µM -1.74165009830889 0.0505165806732198 no 3177 0.0407848446742234 4675 981133 YIL048W NEO1 SGTC_2686 alizarin 95.37 µM -1.74329546625589 0.0503568947869903 no 3178 0.0406410084512054 4569 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_863 0466-0191 129 µM -1.74370826039027 0.0503168955663771 no 3179 0.0406049871266342 4646 765160 YPR165W RHO1 SGTC_162 k030-0015 37.8 µM -1.74475475796727 0.0502156047576528 no 3180 0.0405137835596733 4648 1809920 YMR134W ERG29 SGTC_2072 5231554 129 µM -1.7519932200895 0.0495194349395814 no 3181 0.0398874868705644 4670 789545 SGTC_1546 5-methoxyflavanone 78.7 µM -1.75238954730955 0.0494815411332671 no 3182 0.0398534237823458 4630 147795 SGTC_504 lovastatin 124 µM -1.7542777841214 0.0493013199529957 no 3183 0.0396914602708604 4599 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1957 st077035 62.4 µM -1.75516164874638 0.0492171405072763 no 3184 0.0396158308929351 4629 705593 SGTC_2801 7907800 81.82 µM -1.75546143766432 0.0491886146320572 no 3185 0.039590205576454 4580 6620925 SGTC_152 4469-0003 551.229 µM -1.7554910279185 0.049185799740748 no 3186 0.0395876769958446 4592 697280 SGTC_355 1311-2252 105 µM -1.75847541708064 0.04890255794988 no 3187 0.0393333253891007 4574 5338538 SGTC_1240 0356-0016 42.1 µM -1.75886908655106 0.0488652931420216 no 3188 0.0392998734724031 4570 4305613 SGTC_1149 3909-7961 23.3 µM -1.76014033636518 0.0487451113851204 no 3189 0.0391920075502593 4656 735261 SGTC_1431 4049-0260 9.09 µM -1.76113903696069 0.0486508617599369 no 3190 0.0391074366253394 4645 3854841 SGTC_2139 5578692 56.4705 µM -1.76539892235644 0.0482504815934071 no 3191 0.038748372192624 4596 650991 YMR113W FOL3 SGTC_347 4534-1311 26.2 µM -1.76689809506753 0.0481102053163359 no 3192 0.038622648058264 4624 2862016 SGTC_3266 9136860 49.47 µM -1.76768904319533 0.0480363286068028 no 3193 0.0385564513571218 4359 4871271 YPR165W RHO1 SGTC_1221 2958-7315 257 µM -1.77279273814152 0.0475618101837571 no 3194 0.0381315285879816 4652 4562705 SGTC_1325 1431-0015 227 µM -1.77324278045979 0.0475201480705328 no 3195 0.0380942429908409 4607 1103340 SGTC_1412 3909-8563 178 µM -1.77450247895134 0.0474036884616599 no 3196 0.0379900362066703 4696 23767530 SGTC_395 anisomycin 6.25 µM -1.77723254425743 0.0471520777628053 no 3197 0.0377649934900599 4623 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3191 9110352 49.47 µM -1.77825808698546 0.0470578378564004 no 3198 0.0376807383480556 4575 17122424 SGTC_3005 9076496 71.4286 µM -1.78247540276416 0.0466718836143665 no 3199 0.0373358694514994 4581 21368410 SGTC_944 3370-0224 231 µM -1.78399239779802 0.0465336761385561 no 3200 0.0372124502368112 4586 4580514 SGTC_1789 tunicamycin 25 nM -1.78413619637443 0.0465205922750751 no 3201 0.0372007684341134 4546 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2694 st077685 81.9 µM -1.79114422042202 0.0458865203182568 no 3202 0.0366350772791996 4544 2838096 SGTC_689 0833-0039 98 µM -1.79456099857774 0.0455799052392429 no 3203 0.0363618358854912 4583 5374726 SGTC_3286 9117135 37.221 µM -1.80069833285649 0.0450332911329564 no 3204 0.035875220264696 4569 3438150 SGTC_471 1-acyl-paf 4 µM -1.80180304986459 0.0449354634640409 no 3205 0.0357881988674088 4601 16759367 SGTC_1432 4049-0298 68.4 µM -1.80763255437035 0.0444220643500017 no 3206 0.0353318540166869 4660 741646 SGTC_2270 7924575 90.91 µM -1.80863647561376 0.0443341288536045 no 3207 0.0352537489285054 4593 1262135 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.81438336847253 0.0438334435031119 no 3208 0.0348093622313123 4654 5106787 A p450 inhibitor. SGTC_100 0086-0128 49.5915 µM -1.81954410824791 0.0433877219255325 no 3209 0.0344142299402507 4613 93297 SGTC_2596 sinensetin 100 µM -1.8253142000547 0.0428937123395941 no 3210 0.0339768142643532 4618 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_842 0271-0008 11.1 µM -1.83794044115133 0.0418285616843755 no 3211 0.0330355910302723 4649 1221709 SGTC_2537 larixol 68.93 µM -1.84468550455212 0.0412683851437207 no 3212 0.0325416503475557 4607 6708759 SGTC_3256 9138902 49.47 µM -1.85271838795847 0.0406092057387067 no 3213 0.031961366517644 4738 17228773 SGTC_1980 st071811 45.7 µM -1.86296631380627 0.0397806930143831 no 3214 0.0312335028930364 4686 4974850 SGTC_1373 2887-0003 58.5 µM -1.86485500144938 0.0396295086359254 no 3215 0.0311008656557028 4617 776948 SGTC_1630 st005209 31.3 µM -1.86789560570138 0.0393870983202881 no 3216 0.0308883117610111 4644 3367314 SGTC_2284 7945075 39.21 µM -1.8694526656231 0.0392634305366054 no 3217 0.0307799316209614 4599 1245402 SGTC_2090 5301565 104.445 µM -1.87748735397844 0.0386302973470667 no 3218 0.0302256644820754 4661 2056344 SGTC_2357 9067248 200 µM -1.88171381307291 0.0383006061389362 no 3219 0.0299374416212547 4605 9150235 SGTC_530 4358-1714 28 µM -1.88891985097125 0.0377437811630121 no 3220 0.0294512845490151 4654 1564641 SGTC_1803 st050068 52.4 µM -1.89296994234586 0.0374337342685126 no 3221 0.0291809334049628 4660 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1784 st039334 36.3 µM -1.90074860611858 0.0368440883641739 no 3222 0.0286674743368533 4661 3496984 SGTC_2265 7929201 200 µM -1.90173695322858 0.0367697154799952 no 3223 0.0286027761303098 4644 1265108 SGTC_1292 0kpi-0043 232 µM -1.90682896295866 0.0363884863499534 no 3224 0.028271369741711 4666 3333905 SGTC_2355 9061122 103.12 µM -1.91438438246385 0.0358287929480868 no 3225 0.0277855297949954 4662 5302957 SGTC_2992 9074591 71.4286 µM -1.91587870906096 0.0357189354122684 no 3226 0.0276902680566297 4610 17741321 SGTC_1638 st008370 60.6 µM -1.91678770920835 0.0356522441202876 no 3227 0.0276324535149084 4624 24207134 SGTC_1728 st035614 33.7865 µM -1.92749553279064 0.0348742908801028 no 3228 0.0269589521222937 4613 15945546 SGTC_2360 9040895 200 µM -1.95134572529059 0.0331915331602985 no 3229 0.0255079665771719 4690 4914414 SGTC_3227 9130768 49.47 µM -1.95470485783891 0.0329599930422808 no 3230 0.0253089581951207 4724 17720899 SGTC_1250 0485-0349 40.2 µM -1.96056935194353 0.0325589532968418 no 3231 0.0249646402433006 4641 6842794 YDL195W SEC31 SGTC_2339 9000433 200 µM -1.96090011311657 0.0325364548307449 no 3232 0.0249453380695825 4627 2988954 SGTC_499 genistein 192 µM -1.96507838779345 0.0322533500170082 no 3233 0.0247025827969813 4727 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2990 9074105 71.4286 µM -1.96779050492705 0.0320706771995182 no 3234 0.0245460735697001 4599 6502001 SGTC_1743 st037606 46.3785 µM -1.9761308794277 0.0315142625603026 no 3235 0.024069977932788 4638 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2922 7999257 32.47 µM -1.97787133420466 0.0313991630562098 no 3236 0.0239716117700949 4658 2988377 SGTC_2031 5180455 200 µM -1.9795484691308 0.0312885800630792 no 3237 0.0238771441070039 4681 29949 SGTC_215 1287-0124 461.5 µM -1.99785550249829 0.0301023089945556 no 3238 0.0228661640047241 4720 5560863 SGTC_423 5-fluorouracil 457 µM -2.00297775472772 0.029777150998821 no 3239 0.0225898381191145 4617 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1376 2910-0861 41.3 µM -2.01263191132754 0.0291722310414946 no 3240 0.0220766836280106 4642 1112859 SGTC_1074 carmofur 3.8 µM -2.01501374790127 0.0290245678045597 no 3241 0.0219516043033608 4729 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_567 1080-0542 68.4 µM -2.02007885115294 0.0287126182133171 no 3242 0.0216876045905034 4609 5950415 SGTC_788 1182-0090 188 µM -2.02139668123316 0.0286319142985081 no 3243 0.0216193589938311 4676 5715185 SGTC_34 0469-0683 81.75 µM -2.0374165614694 0.0276658551033551 no 3244 0.0208041578051875 4677 3690923 SGTC_1857 st056007 79.3 µM -2.03941743852052 0.0275471255743908 no 3245 0.0207041917231171 4688 619834 SGTC_2005 4024620 188 µM -2.0395059857352 0.0275418811240212 no 3246 0.0206997772197537 4660 236743 SGTC_32 0928-0142 34.1 µM -2.04319945939358 0.0273238653901769 no 3247 0.0205163486248634 4701 2244242 SGTC_6 0844-0013 19.835 µM -2.05081098381721 0.0268791155381313 no 3248 0.0201426787468499 4766 1584900 SGTC_3285 9112818 20.8695 µM -2.07264134077633 0.0256369487951735 no 3249 0.0191028353194917 4688 17017947 YPR165W RHO1 SGTC_982 1491-0518 27.5 µM -2.07342358390608 0.02559334558811 no 3250 0.019066437991842 4691 3091256 SGTC_2363 9053361 176 µM -2.07417109143008 0.0255517366205853 no 3251 0.0190317120081759 4687 6469797 YMR079W SEC14 SGTC_1262 0737-0114 49.6 µM -2.09935610980808 0.024182598481431 no 3252 0.0178927603226763 4711 765919 SGTC_9 0092-0002 10.449 µM -2.10194657615848 0.0240453342442487 no 3253 0.0177789779530857 4705 759368 SGTC_2942 9052777 62.25 µM -2.12332962154406 0.0229370965756774 no 3254 0.0168631200812821 4707 6469503 SGTC_95 0471-0001 561.058 µM -2.13938813033369 0.0221333863880413 no 3255 0.016202123721143 4690 4015405 SGTC_107 0358-0022 2.6945 µM -2.13982834805117 0.0221116930209302 no 3256 0.0161843206815912 4723 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3206 9114350 49.47 µM -2.14595855348706 0.0218114645110979 no 3257 0.0159381427774705 4608 17087243 SGTC_2368 9071271 200 µM -2.1498662192355 0.0216218880777141 no 3258 0.0157828991868742 4705 27209959 SGTC_1754 st042065 16.137 µM -2.15097971974929 0.0215681233144483 no 3259 0.0157389002211095 4519 1126236 YIL048W NEO1 SGTC_229 benomyl 22.8748 µM -2.15621224950219 0.0213169840152693 no 3260 0.0155335477395242 4741 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1873 rapamycin 2 nM -2.16943389968085 0.0206933969074493 no 3261 0.0150248788165324 4707 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2470 5664817 21.68 µM -2.18875806719131 0.0198098238299208 no 3262 0.0143072145028984 4757 2859561 SGTC_1594 piperine 70.1 µM -2.19089710535545 0.0197140169080739 no 3263 0.0142296196332262 4708 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2028 5153890 36.43 µM -2.19113442091297 0.0197034118924702 no 3264 0.0142210332537972 4707 2830968 YPR165W RHO1 SGTC_2939 9044578 71.43 µM -2.19869685523093 0.0193679937343292 no 3265 0.0139497423605751 4673 2653634 SGTC_21 0849-0113 22.993 µM -2.20298846122659 0.0191798141401009 no 3266 0.0137977809648363 4736 1560156 SGTC_1856 st057054 55.7 µM -2.20652199006363 0.0190260437491587 no 3267 0.013673736139608 4707 1266018 SGTC_3350 9150499 3.57 µM -2.20820545233928 0.0189531531634507 no 3268 0.0136149772499268 4723 4910996 YPR165W RHO1 SGTC_3325 9138760 55.175 µM -2.21274591487093 0.0187577433275636 no 3269 0.0134575839770306 4684 43844959 SGTC_1244 0416-0015 52.5 µM -2.21482981806237 0.0186686330951156 no 3270 0.0133858738655624 4710 96201 SGTC_1904 st060225 78 µM -2.2224591605092 0.0183454612221772 no 3271 0.0131261455264209 4711 66595 SGTC_774 k060-0086 136 µM -2.22363392416901 0.0182961252007166 no 3272 0.0130865420859715 4719 5911235 SGTC_1518 st038567 90.8 µM -2.2272873016627 0.0181434177352599 no 3273 0.0129640393266712 4695 77966 SGTC_2431 5490079 200 µM -2.23336983349881 0.0178915840635587 no 3274 0.0127622829037935 4740 5722345 SGTC_907 3448-6986 75.5 µM -2.24154937936549 0.0175576329619684 no 3275 0.0124952553635026 4723 590582 SGTC_209 4077-0173 175.592 µM -2.26735260325662 0.0165388015933081 no 3276 0.0116843472059184 4723 15993494 SGTC_3028 9087778 49.47 µM -2.27003407001399 0.0164358869829937 no 3277 0.0116027579812454 4711 17217395 SGTC_1909 st060837 51.5 µM -2.28349840798085 0.0159273757893107 no 3278 0.0112005132643481 4694 678937 SGTC_920 mycophenolic acid 780.421 nM -2.28969453715251 0.0156979342559668 no 3279 0.0110195151585995 4723 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2688 kanamycin b 96.69 µM -2.30567016495291 0.0151193996181016 no 3280 0.0105645347057094 4680 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1072 oxiconazole 14.9 nM -2.32324620413964 0.0145041666123733 no 3281 0.0100829649740361 4714 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1690 st023502 41.2 µM -2.35272562676665 0.0135206158322984 no 3282 0.00931818982803622 4762 24207482 SGTC_1195 1502-0147 41.1 µM -2.36392170409148 0.0131624493858596 no 3283 0.00904131686220913 4757 817940 SGTC_1080 nisoldipine 24.4 µM -2.37049505921892 0.0129560088957338 no 3284 0.00888214068062834 4773 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1844 rapamycin 4 nM -2.37812811091338 0.0127198063355831 no 3285 0.00870038961539684 4603 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2033 5192550 145 µM -2.39204009836429 0.0122988784154924 no 3286 0.00837750586984926 4745 182073 SGTC_1189 1431-2119 7.28 µM -2.39288601555955 0.0122736777468419 no 3287 0.00835821670859617 4753 3107275 SGTC_2133 5320837 200 µM -2.39313677961184 0.0122662158524848 no 3288 0.00835250611959442 4735 2841355 SGTC_1964 st076914 61 µM -2.39715956930354 0.0121470473952248 no 3289 0.0082613632595621 4770 24208661 SGTC_3134 9127454 49.47 µM -2.39764550875552 0.0121327204029853 no 3290 0.00825041285854497 4743 24262820 SGTC_1966 st070145 16.1 µM -2.40131011646196 0.0120251474565501 no 3291 0.00816824256757066 4747 3748532 SGTC_573 3702-0553 84.7 µM -2.40699086220726 0.0118600264529087 no 3292 0.00804228615658042 4736 1222756 SGTC_2293 7624732 200 µM -2.4126227305068 0.0116982714992511 no 3293 0.00791910206263202 4674 894453 SGTC_2285 7945142 200 µM -2.42068128071841 0.0114701507116616 no 3294 0.00774572651274886 4737 2970608 SGTC_105 0111-0055 734.78 µM -2.42488424604377 0.0113527140496225 no 3295 0.00765663425141988 4752 5179370 SGTC_1905 st060207 84.5 µM -2.43636242504414 0.011037305771296 no 3296 0.00741790584221046 4745 1948547 SGTC_1596 piperlongumine 63 µM -2.44110914284634 0.0109091156049938 no 3297 0.00732111439175021 4764 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2426 5582046 32.21 µM -2.45077734858579 0.0106520170111266 no 3298 0.00712740487236208 4741 2251934 SGTC_2305 7443522 69.23 µM -2.45524393461 0.010535033789619 no 3299 0.00703945080851958 4709 5415886 SGTC_555 4296-0685 37 µM -2.45541038850145 0.0105306959578276 no 3300 0.00703619166616185 4766 2908540 YHR072W ERG7 SGTC_2036 5160441 105 µM -2.45971751820439 0.0104189908872979 no 3301 0.00695232048459912 4741 134534 YIL048W NEO1 SGTC_2287 7945887 168.79 µM -2.46770303814955 0.0102146174041676 no 3302 0.006799153926573 4763 1245853 SGTC_309 k408-0051 1.48 µM -2.49266844495371 0.00959806406395327 no 3303 0.0063393588069583 4697 3640463 SGTC_1963 st076565 50.3 µM -2.50042171443563 0.00941332592883527 no 3304 0.00620227728388427 4771 4914280 SGTC_2264 7948757 110.76 µM -2.52517803728408 0.00884411204528349 no 3305 0.00578198442156464 4734 2971411 SGTC_1819 st053448 58.6 µM -2.54303747010749 0.00845242721478589 no 3306 0.00549467218340535 4765 2857616 SGTC_1800 st050079 29.0735 µM -2.543762725005 0.00843684810832859 no 3307 0.00548327754722273 4666 3645560 SGTC_260 nsc-65238 3.989 µM -2.55889561778547 0.00811748055639426 no 3308 0.00525026326531389 4770 3246252 SGTC_844 0330-0132 15.3 µM -2.57335928745842 0.00782221606677493 no 3309 0.00503582962081448 4772 2828079 SGTC_1628 st004252 77.7 µM -2.58077261061778 0.00767457378953151 no 3310 0.00492897448790522 4760 692968 SGTC_2394 5221648 200 µM -2.58639884455402 0.00756416573652435 no 3311 0.00484923165124426 4757 788586 SGTC_909 3448-9333 149 µM -2.6041589996843 0.00722476739139583 no 3312 0.00460500095547388 4747 3344074 SGTC_2057 5236571 38.335 µM -2.60691681016722 0.00717328791205681 no 3313 0.0045680776936248 4732 54684039 YBR257W POP4 SGTC_1021 4476-0760 85.3 µM -2.60819732509298 0.00714949499401589 no 3314 0.00455102339152776 4779 746768 SGTC_94 0334-0113 514.748 µM -2.62416910802171 0.00685852481484382 no 3315 0.00434303232030807 4770 6795178 SGTC_2044 5102272 200 µM -2.68662225079705 0.00581871204881371 no 3316 0.00360892648690612 4780 592666 SGTC_1651 st011928 86.1 µM -2.69411234180715 0.00570391141271275 no 3317 0.00352881861049968 4781 720198 SGTC_3037 9091026 49.47 µM -2.72065984153516 0.0053130422154591 no 3318 0.00325758826061599 4702 25236398 YIL048W NEO1 SGTC_549 1661-1316 519 µM -2.74696908771599 0.00494936619033822 no 3319 0.00300744016656095 4792 2857282 SGTC_1818 st052136 56.3 µM -2.78716717765452 0.00443645467355055 no 3320 0.00265855204375811 4619 674169 SGTC_2781 5567276 71.43 µM -2.81416680517493 0.00411915221446201 no 3321 0.0024451922584333 4754 2853274 SGTC_383 2324-0395 7.37 µM -2.85167581045252 0.00371205422189415 no 3322 0.00217447146631729 4778 3146421 SGTC_1852 st056254 31.4 µM -2.8704939630901 0.00352173222635859 no 3323 0.00204915511207056 4781 442583 SGTC_2071 5230951 39.92 µM -2.87159738097947 0.00351084943940261 no 3324 0.00204201464619835 4782 1799272 SGTC_1978 st071761 42 µM -2.88114105559029 0.00341797506672494 no 3325 0.00198119134252576 4783 5147680 SGTC_256 clotrimazole 625 nM -2.89790214864618 0.00326019392394772 no 3326 0.0018783388821453 4770 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2300 7976697 71.57 µM -2.90413781551483 0.00320318698511132 no 3327 0.0018413300784712 4738 2236109 SGTC_2079 5212404 121 µM -2.94890924009022 0.00281953481524528 no 3328 0.00159448806726535 4770 758462 SGTC_553 k007-0256 45.7 µM -2.98267495600033 0.00255816669999513 no 3329 0.00142870640691834 4798 6287000 SGTC_181 1447-1644 8.07 µM -3.00579593581107 0.00239204360889109 no 3330 0.0013244334937075 4767 534600 SGTC_15 0266-0086 27.098 µM -3.09718613808174 0.00182673373658657 no 3331 0.000976835788000495 4800 1712902 YIL048W NEO1 SGTC_1504 k297-0033 30 µM -3.13957887069147 0.00160828746115978 no 3332 0.000845954317492029 4775 4388117 SGTC_3321 9137793 26.8275 µM -3.21271789915947 0.00128661628229893 no 3333 0.000657426834809988 4796 4904192 SGTC_1859 st055998 20 µM -3.23403000361313 0.00120463131764667 no 3334 0.000610283161110841 4778 676301 SGTC_2367 9070478 135.38 µM -3.24298599610493 0.00117162837079821 no 3335 0.000591420124303726 4791 572802 SGTC_528 3492-0019 172 µM -3.26660104536217 0.00108853695441992 no 3336 0.000544234776874492 4791 2869262 SGTC_2679 rapamycin 1 nM -3.31833897217272 0.00092504466386659 yes 3337 0.000452772591583443 4715 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2001 4023502 57.655 µM -3.31962881920929 0.000921273365727675 yes 3338 0.000450686037325112 4796 108941 YCR052W RSC6 SGTC_794 k038-0031 316 µM -3.36259713474363 0.000803431686055424 yes 3339 0.000386064780786544 4799 6624242 SGTC_2404 5161160 200 µM -3.38187497891335 0.000755211741834229 yes 3340 0.00035996450710861 4793 2831543 SGTC_3290 9121031 71.43 µM -3.48988255833023 0.000530919721396754 yes 3341 0.000241616429966844 4802 17014854 SGTC_1150 3909-7983 10.9 µM -3.5586566490753 0.000422104395930653 yes 3342 0.000186378222879303 4805 23965914 SGTC_404 fumagillin 50 µM -3.58203752982503 0.000390096997289426 yes 3343 0.00017046240007511 4803 12015870 A methionine aminopeptidase binder. SGTC_1780 st038448 24.544 µM -3.6639084344492 0.00029492769168728 yes 3344 0.00012419780757524 4798 728868 YDL195W SEC31 SGTC_1203 3992-3522 103 µM -3.69638231943211 0.000263558598699317 yes 3345 0.000109346780280154 4789 5322312 SGTC_3335 9143315 29.6265 µM -3.70858733195353 0.000252594746178429 yes 3346 0.000104209389041799 4801 4899691 SGTC_514 4466-0038 2.65 nM -3.79190828451464 0.00018837666793972 yes 3347 7.47470635437525e-05 4754 5722064 SGTC_1205 4161-2785 76 µM -3.93281674752938 0.00011321872461849 yes 3348 4.19781208315691e-05 4796 3498106 SGTC_2584 androsterone 48.74 µM -3.93918568993086 0.000110600219998331 yes 3349 4.08793173209544e-05 4785 2754130 A steroid. SGTC_3337 9144342 33.5465 µM -4.03514072822126 7.74257353014438e-05 yes 3350 2.72847902362962e-05 4809 17682949 SGTC_1465 k213-0056 144 µM -4.06371065100671 6.95238152840235e-05 yes 3351 2.41493466598655e-05 4781 24048857 YMR208W ERG12 SGTC_392 N-ethylmaleimide 8.33 µM -4.52696812037068 1.10386196638315e-05 yes 3352 2.99179813043303e-06 4807 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_377 3970-0964 33.1 µM -5.50328498820637 1.26711217417978e-07 yes 3353 1.86389545820767e-08 4810 16481235 SGTC_304 1310-0298 97 µM -8.84746300987215 6.14198653569214e-17 yes 3354 4.47656484682889e-19 4809 1550234