SGTCid condition conc unit PSH1|YOL054W.score PSH1|YOL054W.strain.pval PSH1|YOL054W.strain.significant PSH1|YOL054W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2619 obliquin 87.91 µM 9.12176224611108 1.11466381311671e-18 yes 1 3.69562666798482e-20 31 6708593 A bioactive alkalod. YER133W GLC7
SGTC_514 4466-0038 2.65 nM 6.3914042457568 4.44548532342731e-10 yes 2 8.218459993814e-11 65 5722064
SGTC_58 0957-0393 9 µM 6.17671240653583 1.58663034676163e-09 yes 3 3.2725068619516e-10 205 6997992
SGTC_3164 9100705 49.47 µM 5.51676931445034 6.12065308099698e-08 yes 4 1.72644094838645e-08 1 17174235
SGTC_1101 ebselen 5.29 µM 5.15351289880973 3.87232997996956e-07 yes 5 1.27825740362758e-07 8 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1387 3342-1166 1.8 µM 5.08639721046857 5.3755488522616e-07 yes 6 1.82464677823637e-07 4 3418228
SGTC_3186 9110464 49.47 µM 5.01760822928956 7.4924432777557e-07 yes 7 2.61593644863945e-07 3 17018021
SGTC_214 4373-3496 70 µM 4.92058529305318 1.18826505479397e-06 yes 8 4.31428934625248e-07 32 3779166
SGTC_312 4092-0653 6.84 µM 4.90234989353439 1.29465296868283e-06 yes 9 4.73484853904122e-07 59 1148278
SGTC_1707 st032323 6.317 µM 4.72335878249336 2.95735687269317e-06 yes 10 1.1599053102313e-06 38 3132057 YMR211W DML1
SGTC_1000 4048-0884 8.67 µM 4.6707302442489 3.75013759578177e-06 yes 11 1.50065432140293e-06 20 13040088
SGTC_1652 st011932 78 µM 4.59526374422658 5.24924335785287e-06 yes 12 2.16101121539545e-06 7 1551076
SGTC_547 1120-0019 610 nM 4.52380118556825 7.18434168403834e-06 yes 13 3.03693914364379e-06 22 3676939
SGTC_3311 9131146 2.8755 µM 4.3949806817374 1.25064610029618e-05 yes 14 5.53913026552232e-06 105 4900406 YPR165W RHO1
SGTC_2621 lithochol-11-enic acid 100 µM 4.37942789477422 1.33589257292224e-05 yes 15 5.94956422707235e-06 15 6708711
SGTC_3002 9075603 71.4286 µM 4.16542339496381 3.23928860714205e-05 yes 16 1.55387632849682e-05 17 20105405
SGTC_2808 7946468 45.46 µM 3.87824543350288 9.98400490362822e-05 yes 17 5.26062720642086e-05 24 2970879
SGTC_3218 9131285 49.47 µM 3.84949465686984 0.000111307887676749 yes 18 5.91808826869869e-05 49 17156417
SGTC_1825 st052143 62.6 µM 3.8476258126648 0.000112094569243304 yes 19 5.96340159504033e-05 15 674173
SGTC_212 3807-4682 38.772 µM 3.83692164780232 0.000116701931015461 yes 20 6.22930998036806e-05 74 3125501 YBL034C STU1
SGTC_2102 5377816 72.7585 µM 3.81875862306968 0.000124928704552363 yes 21 6.70624604726668e-05 30 1379702
SGTC_1132 3456-3614 2.5 µM 3.78399242153951 0.000142214035577325 yes 22 7.716626225922e-05 58 3125502
SGTC_159 3970-0959 50 µM 3.76154733902275 0.000154537781635238 yes 23 8.44327261530623e-05 85 6615653
SGTC_1117 retinoic acid 1.10837 µM 3.76114136923201 0.000154769625812223 yes 24 8.45698987426097e-05 19 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_149 3970-0822 46.1 µM 3.73773858964711 0.000168698800185497 yes 25 9.28414282360392e-05 109 3114250 YBL034C STU1
SGTC_1942 st076330 65.2 µM 3.68378497605778 0.000205404177546857 yes 26 0.000114898054290531 34 24208414
SGTC_2755 lomerizine 42.69 µM 3.66494284143278 0.000219891803729779 yes 27 0.000123696914201971 29 3949 A calcium channel blocker.
SGTC_3133 9127736 49.47 µM 3.6534532369492 0.000229188528767176 yes 28 0.000129368464021543 28 27243420
SGTC_558 k064-0027 21.3 µM 3.61221822285678 0.000265659950919016 yes 29 0.000151794457449661 33 5088526
SGTC_2783 7738165 71.43 µM 3.60336987620107 0.000274160380019777 yes 30 0.000157059017683707 40 17201110
SGTC_2801 7907800 81.82 µM 3.56218524895151 0.000317164563124966 yes 31 0.000183890356933705 42 6620925
SGTC_2027 5150920 200 µM 3.50745519133493 0.000384053575068581 yes 32 0.000226207269481556 21 786715
SGTC_2582 agaric acid 100 µM 3.39967488520721 0.000555614435476223 yes 33 0.000337330099847741 380 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_852 0418-0143 439 µM 3.39470448960605 0.000565021317808012 yes 34 0.000343513560834003 99 5369229
SGTC_52 0329-0193 875 nM 3.38153694812295 0.000590658289489709 yes 35 0.000360407691612555 58 3739292
SGTC_1106 tegaserod maleate 11.7 µM 3.35820587102575 0.000638739288253558 yes 36 0.000392250807134132 46 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2187 6125751 200 µM 3.33657296460387 0.000686523734728804 yes 37 0.000424090807327085 38 874498
SGTC_462 ag-879 158 µM 3.30098141454274 0.000772368326440941 yes 38 0.000481736323065779 53 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2584 androsterone 48.74 µM 3.26832279801007 0.000859728436474417 yes 39 0.000540934497943338 181 2754130 A steroid.
SGTC_3003 9075612 71.4286 µM 3.24530899202068 0.000926650932075277 yes 40 0.000586616214632035 45 6501993
SGTC_39 0986-0283 58.349 µM 3.23189793296764 0.000967823750586634 yes 41 0.00061485485672416 66 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_548 1436-0017 110 µM 3.19019547909003 0.00110682168068128 no 42 0.000710882948869277 68 9677137
SGTC_546 peri-Naphthalide 147 µM 3.1807923520534 0.0011405904272574 no 43 0.000734364310860791 40 223824 A penicillin ester.
SGTC_1413 3910-0535 34.4 µM 3.13920951335498 0.00130153368464782 no 44 0.000847021399830662 36 2876951
SGTC_1872 amphotericin b 148 nM 3.13351083882802 0.00132513936770721 no 45 0.000863642695328361 52 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_310 1273-0058 1.06 µM 3.11848407142046 0.00138927345995436 no 46 0.000908919838222715 331 2734232
SGTC_379 3970-0972 5.9 µM 3.10753091033154 0.00143779422446028 no 47 0.000943286276901973 75 2898042 YBL034C STU1
SGTC_381 3461-2219 42.7 µM 3.0849447289002 0.00154276503357881 no 48 0.00101794991567412 53 2883159
SGTC_2074 5212007 75.395 µM 3.05706619292673 0.0016819506085719 no 49 0.00111757455858151 37 758611
SGTC_839 0122-0028 230 µM 3.03283903775192 0.00181209045555748 no 50 0.00121132392743379 87 759448
SGTC_934 2950-0684 338 µM 2.97814813857366 0.00214016675533571 no 51 0.00144997892733687 59 1121253
SGTC_955 1216-0110 33 µM 2.94785758043309 0.00234421879802263 no 52 0.00159992222357369 126 3619719
SGTC_2309 7664088 163.95 µM 2.91893782170771 0.00255530822628457 no 53 0.00175613136366584 112 704922
SGTC_540 1187-0821 17.3 µM 2.89251895843685 0.00276300192616192 no 54 0.00191083058496524 57 847520
SGTC_2965 9082772 38.63 µM 2.87375461008984 0.00291964541037542 no 55 0.00202811992437273 96 16459634
SGTC_1416 3966-0321 25.3 µM 2.86417567197036 0.00300265756079903 no 56 0.00209048033586424 77 582530 YLR208W SEC13
SGTC_1560 lithocholic acid 53.1 µM 2.85597058243853 0.00307544816777637 no 57 0.00214527442778556 26 9903 A bile acid which acts as a detergent.
SGTC_351 caspofungin 25 nM 2.85345109601592 0.00309811628299026 no 58 0.00216235918592452 187 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1466 k213-0079 57.5 µM 2.82482900384808 0.00336639833248281 no 59 0.00236529271815186 71 3657981
SGTC_1915 st067105 30.6 µM 2.8212512343653 0.00340136196130878 no 60 0.00239183614823804 115 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2126 5251174 33.877 µM 2.81692166345183 0.00344410871893177 no 61 0.00242431750899383 123 790722
SGTC_1964 st076914 61 µM 2.80976784092208 0.0035157983607983 no 62 0.00247886239597335 73 24208661
SGTC_108 0509-0257 621.132 µM 2.80536155983079 0.00356061853247289 no 63 0.00251300833228868 120 536624
SGTC_375 3970-0961 9.27 µM 2.79289716217423 0.00369019581906782 no 64 0.00261191481598888 87 2898222
SGTC_1853 st056710 91.2 µM 2.78969961916308 0.00372411140465802 no 65 0.00263784814541789 90 269167
SGTC_829 1635-0120 117 µM 2.78087597586517 0.00381915650470188 no 66 0.00271062219775581 109 285054
SGTC_189 3970-0742 2.116 µM 2.7737390182977 0.00389761768115744 no 67 0.0027708057503199 39 2891807
SGTC_859 0439-0102 54.6 µM 2.76801807814957 0.00396155119438478 no 68 0.00281991635738262 78 610143
SGTC_2289 7946404 165.07 µM 2.72948995305193 0.00441713038758349 no 69 0.00317161909708829 182 1246120 YPR165W RHO1
SGTC_1921 5740136 50 µM 2.72653194162497 0.00445397053401009 no 70 0.00320018787549264 151 1774243
SGTC_2229 7354935 190 µM 2.71869431017048 0.00455291363911371 no 71 0.00327700739134752 44 318112
SGTC_1733 st037357 54.9 µM 2.71481106033526 0.00460265938176709 no 72 0.00331567957480733 132 1272339 YGL099W LSG1
SGTC_334 1502-1024 68.5 µM 2.71242100843996 0.00463351738048786 no 73 0.0033396849398453 78 3296216
SGTC_2635 hydroquinidine 100 µM 2.71095111283776 0.00465258678332791 no 74 0.00335452585718759 77 442912 An experimental heart treatment.
SGTC_2671 danthron 100 µM 2.69171965490691 0.00490861279011211 no 75 0.00355423354339386 115 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1472 k841-0093 193 µM 2.68492205818422 0.00500206747391832 no 76 0.00362733610052637 99 X1472
SGTC_2174 5790901 200 µM 2.68270835642816 0.00503284215574493 no 77 0.0036514322509879 104 786020
SGTC_2596 sinensetin 100 µM 2.66939717064301 0.00522147358554986 no 78 0.00379937683244196 100 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1723 st034307 2.5525 µM 2.66296886377118 0.00531480083688556 no 79 0.00387272903332481 105 867466
SGTC_329 k048-0121 21.3 µM 2.65663993412466 0.00540813160974505 no 80 0.00394618442407253 83 6832902
SGTC_2086 5274770 176.623 µM 2.62788732418191 0.00585073165561064 no 81 0.00429584845144852 105 689278
SGTC_2396 5342950 42.78 µM 2.62701002248381 0.00586472740655633 no 82 0.00430693984370778 144 1886677
SGTC_2420 aureobasidin a 50 nM 2.62663226369501 0.00587076300140402 no 83 0.00431172358391206 138 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1034 k072-0165 12.7 µM 2.62569711012317 0.00588572801111784 no 84 0.00432358631879317 104 5835461
SGTC_1388 3346-4487 254 µM 2.62038709709203 0.00597134594112228 no 85 0.00439150037353498 107 3345614
SGTC_605 1315-0399 119 µM 2.61089055356129 0.00612722352430925 no 86 0.00451533950018456 105 24020461
SGTC_3162 9099653 49.47 µM 2.5903231559742 0.0064772345990591 no 87 0.00479429366805141 55 25237511
SGTC_459 nigericin 15.3 µM 2.58514440993077 0.00656810617443295 no 88 0.0048669109542938 149 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_478 N-arachidonylglycine 10 µM 2.58206904973962 0.00662260149693466 no 89 0.00491049665559136 31 5283389
SGTC_595 3909-8003 73.7 µM 2.57886257046449 0.00667984553621988 no 90 0.00495631070536191 85 699517
SGTC_141 0443-0274 32.331 µM 2.57691944024769 0.00671474791824903 no 91 0.00498425901732163 172 1627241
SGTC_1063 disulfiram 1.84 µM 2.57480348006711 0.00675293787350958 no 92 0.0050148527557539 122 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1552 6-methylflavone 10.6 µM 2.57013689695056 0.0068378418709239 no 93 0.00508291669489289 68 689013
SGTC_527 4476-4215 268 µM 2.56822474018424 0.00687290316745017 no 94 0.00511104297464543 134 4418754
SGTC_3238 9133470 49.47 µM 2.5598587858478 0.00702817499592965 no 95 0.00523573517894442 69 3534688
SGTC_1732 st034308 51.822 µM 2.55495232657056 0.00712067196828273 no 96 0.00531011712638185 114 830119
SGTC_2109 5483026 200 µM 2.54156651488274 0.00737850624075423 no 97 0.00551784730898759 128 759335
SGTC_251 melphalan 456.522 µM 2.53330891472374 0.00754163456009912 no 98 0.00564956634341904 140 460612 A DNA alkylator.
SGTC_2041 5107442 45.335 µM 2.52559286125045 0.00769692695613297 no 99 0.00577516257682821 135 793005
SGTC_3050 9093513 49.47 µM 2.51822322118595 0.007847868379909 no 100 0.00589742719023149 94 25236664
SGTC_673 1082-0474 110 µM 2.50493848632796 0.00812654714964878 no 101 0.00612363457411906 196 3098046
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.50139553427094 0.0082023224835372 no 102 0.00618524661086938 129 5355888
SGTC_2210 7115885 190.385 µM 2.48777890639204 0.00849935739669872 no 103 0.00642718088126893 130 2927039
SGTC_798 1287-0182 476 µM 2.48592795396862 0.00854045450475651 no 104 0.00646070609566798 128 1649755
SGTC_3187 9109394 49.47 µM 2.47903120702656 0.00869512361642967 no 105 0.00658698896514411 134 17098090
SGTC_1204 4049-0315 18.3 µM 2.47789676494854 0.00872079892710527 no 106 0.00660796889218692 134 588402
SGTC_1201 1889-3372 45.9 µM 2.47712367795287 0.00873833391651166 no 107 0.00662229988800421 80 5392199
SGTC_2262 9014885 67.46 µM 2.46226827504366 0.00908133658320785 no 108 0.00690306773414653 49 6457424
SGTC_930 2810-3379 265 µM 2.46069612111203 0.00911831759897747 no 109 0.00693338800734218 116 1015764
SGTC_304 1310-0298 97 µM 2.44522223409813 0.0094893950320389 no 110 0.00723814549223271 190 1550234
SGTC_1385 3091-4834 14.1 µM 2.42929419011419 0.00988508909702294 no 111 0.00756412564528262 105 4072814
SGTC_1392 3455-1037 33.9 µM 2.39928848263774 0.0106697757695676 no 112 0.00821348363298595 118 981132
SGTC_3157 9099274 49.47 µM 2.39615903800808 0.0107546574551893 no 113 0.00828394993588339 101 17217662
SGTC_1837 st055472 66.5 µM 2.39586986548783 0.010762530436261 no 114 0.00829048800789601 129 676091
SGTC_759 3486-0358 89.3 µM 2.37398520805864 0.011373106521953 no 115 0.00879862771878831 141 875103
SGTC_768 0384-0033 77.3 µM 2.3625430045338 0.0117041618392661 no 116 0.00907501775178883 226 3965305 YMR134W ERG29
SGTC_2959 9079155 11 µM 2.36167878413993 0.0117295025333434 no 117 0.00909619877167997 128 16189457
SGTC_1181 1222-0449 220 µM 2.3443422131175 0.0122479990376436 no 118 0.00953033681536903 142 658318
SGTC_115 0527-0192 112.043 µM 2.34341819915865 0.0122761831211553 no 119 0.00955397590293641 243 4233931
SGTC_1456 k015-0012 13 µM 2.34260276594658 0.012301101956133 no 120 0.00957487972573085 160 2989616
SGTC_2225 6654152 15.4 µM 2.33697142197972 0.0124743895948909 no 121 0.0097203350463375 83 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_31 0508-1974 57.237 µM 2.32918563725194 0.0127174529812163 no 122 0.00992461673248602 136 6810525
SGTC_1610 st001799 48.1 µM 2.32436011659374 0.0128701484749923 no 123 0.0100531006389896 114 621897
SGTC_2384 9036245 200 µM 2.31920363660453 0.0130350666232005 no 124 0.0101919986934581 136 6462766
SGTC_2038 4100038 30.985 µM 2.31280072321201 0.0132423890191355 no 125 0.0103667990068172 171 3596803
SGTC_2576 guaiol 23.12 µM 2.31003031662297 0.0133329723146292 no 126 0.0104432378797016 159 227829
SGTC_565 1418-0001 44.5 µM 2.30633175714388 0.0134547369866959 no 127 0.0105460509797003 174 2862145
SGTC_1715 st032160 10.2275 µM 2.30040314742656 0.0136519227624224 no 128 0.0107126953425035 168 5289825
SGTC_3148 9097893 49.47 µM 2.29426194154651 0.0138588038460884 no 129 0.0108877286314236 174 17174100
SGTC_1040 k898-0338 155 µM 2.29310108482483 0.0138982124047844 no 130 0.010921092976889 156 20969351
SGTC_3138 9097216 49.47 µM 2.2875372385977 0.0140884370211816 no 131 0.0110822422225405 131 25237486
SGTC_2894 9048625 32.47 µM 2.2851591081517 0.0141704258644982 no 132 0.0111517499831025 136 4092861
SGTC_2179 6298986 200 µM 2.26822986247883 0.0147660476939015 no 133 0.0116576001184227 125 738374
SGTC_2539 epi(13)torulosol 80 µM 2.24392240113369 0.0156588462450452 no 134 0.0124186972806813 165 6708597
SGTC_2935 9038016 29.96 µM 2.23821851683847 0.0158749319570448 no 135 0.0126034043563573 162 6463195
SGTC_309 k408-0051 1.48 µM 2.2357955434792 0.0159674946636025 no 136 0.01268258350153 249 3640463
SGTC_1698 5-fluorocytosine 1.055 µM 2.22589215770641 0.0163506504264801 no 137 0.0130107028959437 127 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1968 st069590 43.6 µM 2.22578299496122 0.0163549173583211 no 138 0.0130143601947888 142 6384066
SGTC_453 enantio-paf c16 10 µM 2.22275208501818 0.0164737703330529 no 139 0.0131162608222312 401 13871343 A lipid and platelet activating factor
SGTC_2096 5468907 200 µM 2.21340095994105 0.0168451324392733 no 140 0.0134350072734542 145 759785
SGTC_1353 1498-1206 8.11 µM 2.21323303949708 0.0168518659876717 no 141 0.0134407916797098 223 6756808
SGTC_590 k048-0076 22.4 µM 2.20908315094896 0.0170190078878214 no 142 0.0135844289195727 145 6832814
SGTC_2024 5144227 134 µM 2.20497596856241 0.0171858230162291 no 143 0.0137278904574375 191 3475211
SGTC_1131 3454-3128 32.3 µM 2.20391063363256 0.0172293195919477 no 144 0.013765314787609 220 710982
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.19826065666326 0.0174615779224956 no 145 0.0139652681837215 200 23847180
SGTC_1097 itavastatin 7.23 µM 2.19519376987049 0.0175887666903335 no 146 0.0140748504977755 186 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3069 9117009 49.47 µM 2.19211271324687 0.0177173385079386 no 147 0.0141856844969815 80 41904981
SGTC_1496 4469-0713 57.4 µM 2.19130949286248 0.017750988203194 no 148 0.0142147017886582 147 746691
SGTC_1500 4488-1866 171 µM 2.17362850006436 0.0185056349600498 no 149 0.0148665231323174 167 2900003
SGTC_842 0271-0008 11.1 µM 2.17324429154767 0.0185223321592238 no 150 0.0148809679256097 166 1221709
SGTC_665 3914-0008 307 µM 2.1721315096867 0.0185707646014893 no 151 0.0149228724433107 179 1069549
SGTC_3305 9127027 53.8275 µM 2.16940026152635 0.0186900960636502 no 152 0.0150261545703143 182 41905295
SGTC_769 0302-0231 76 µM 2.16434757757495 0.0189125746633334 no 153 0.0152188419271473 250 571869 YER009W NTF2
SGTC_2249 haloperidol 116.36 µM 2.16035901825567 0.0190897853507401 no 154 0.0153724437030674 348 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_43 0570-0105 72.5 µM 2.14219034754548 0.0199149821219733 no 155 0.016089083962812 356 1114046 YDL195W SEC31
SGTC_1137 ixabepilone 100 µM 2.13766325279311 0.0201252446280089 no 156 0.0162720420044641 234 154225 A novel microtubule stabilizer.
SGTC_1845 st056753 3.01 µM 2.12959048138818 0.0205048600804458 no 157 0.0166027187940594 222 5375839
SGTC_1976 st070609 63.5 µM 2.12637090008462 0.0206579416584375 no 158 0.016736194392877 161 682556
SGTC_1493 4348-0038 111 µM 2.12283891476045 0.0208269894263704 no 159 0.0168836763278606 218 800424
SGTC_3247 9135149 49.47 µM 2.12010961697216 0.020958419837191 no 160 0.0169984010636901 143 8934436 YOR116C RPO31
SGTC_1314 1222-0010 41.1 µM 2.11347370577659 0.021280905763781 no 161 0.0172801216225281 169 3526027
SGTC_1368 1852-0141 284 µM 2.11086991711041 0.0214085836452362 no 162 0.0173917472216756 200 2838987
SGTC_1048 3161-0300 24.5 µM 2.10907252083234 0.0214970970600104 no 163 0.017469161175283 196 2165101
SGTC_2629 bisabolol 100 µM 2.10733063470217 0.0215831718043232 no 164 0.017544464835644 220 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_608 k048-0125 159 µM 2.10562704270605 0.0216676357930829 no 165 0.0176183808548624 180 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_944 3370-0224 231 µM 2.09645630484332 0.0221271332224598 no 166 0.0180208660850494 196 4580514
SGTC_2421 5690543 90.72 µM 2.09606137520771 0.0221471043858924 no 167 0.0180383733955746 194 3397993
SGTC_138 0850-0259 40.9225 µM 2.09223463057223 0.0223414077489946 no 168 0.0182087660251172 407 6813004
SGTC_3047 9092122 49.47 µM 2.09098075484576 0.0224053853840828 no 169 0.0182648945940116 192 17173831
SGTC_1052 3253-3998 198 µM 2.08771246112455 0.022572873176669 no 170 0.0184118900493726 234 5450317
SGTC_2416 tofa 880 nM 2.08296159226235 0.02281821894516 no 171 0.0186273623050313 235 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.08251123584905 0.0228415925400063 no 172 0.0186478988362029 162 6857784
SGTC_184 1494-0393 24.714 µM 2.06956470525147 0.0235221960375481 no 173 0.0192465630594255 249 3090647
SGTC_2223 6903751 107.57 µM 2.06677547373064 0.0236710393102851 no 174 0.0193776577860574 132 5598863
SGTC_1403 3909-7815 62.9 µM 2.06422960839146 0.0238075863125642 no 175 0.019497975740841 157 6615483
SGTC_2340 7987427 183.45 µM 2.05837934351656 0.0241238749001539 no 176 0.019776866523647 213 2239331
SGTC_1955 wogonin 32.4 µM 2.0466900252141 0.0247664252320257 no 177 0.0203442646281084 179 5281703 A flavanone.
SGTC_2246 7293507 91.5585 µM 2.03160331402667 0.0256168910615677 no 178 0.0210969154680514 220 887656
SGTC_554 4483-2211 187 µM 2.03083284470831 0.0256609721375276 no 179 0.0211359769917817 204 747107
SGTC_1636 st007707 68.9 µM 2.00928415143099 0.0269198055564463 no 180 0.0222535038461792 263 403051
SGTC_3197 9113331 49.47 µM 2.00049254900852 0.0274479978482129 no 181 0.0227235518463814 257 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_93 0109-0045 59.227 µM 1.99980348971391 0.0274897586518825 no 182 0.0227607438135906 281 88733
SGTC_3350 9150499 3.57 µM 1.99851782086568 0.027567818925329 no 183 0.0228302749304333 282 4910996 YPR165W RHO1
SGTC_2171 5739187 198.077 µM 1.98091177493632 0.0286554996017053 no 184 0.0238005841800121 179 2262761
SGTC_2645 abamectin 100 µM 1.97761778491147 0.0288629108342547 no 185 0.0239859206877875 236 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1820 st053765 18.6 µM 1.97552637638535 0.0289952462201893 no 186 0.024104222188372 207 3690829
SGTC_81 0411-0046 9.971 µM 1.97152033427745 0.0292501394612149 no 187 0.0243321947351532 200 12925265
SGTC_1529 apigenin 74 µM 1.96889163233647 0.0294184055821629 no 188 0.0244827683248749 260 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2970 9090938 41.86 µM 1.9626292151672 0.0298225097752519 no 189 0.0248446367373079 331 17217104
SGTC_343 4130-2827 29.8 µM 1.9601843785924 0.0299815161455182 no 190 0.0249871218359845 244 1118244
SGTC_986 1493-0483 84 µM 1.95102387797543 0.0305835580185053 no 191 0.0255271026975881 203 40079
SGTC_2190 6049624 200 µM 1.95063855252304 0.0306091000563819 no 192 0.0255500288566803 165 2265554
SGTC_702 1488-0190 94 µM 1.94970603443892 0.030670986927057 no 193 0.0256055833347262 193 949357
SGTC_1173 0443-0020 122 µM 1.94613242681638 0.0309091106858235 no 194 0.0258194171592049 255 5331295
SGTC_3073 9114972 49.47 µM 1.93665301243047 0.0315481834113073 no 195 0.0263938865453561 200 41905075
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.92711769348393 0.032202004375016 no 196 0.0269824820959493 233 4330530
SGTC_2194 5927483 104.545 µM 1.92171538715063 0.0325773685781156 no 197 0.0273207900150425 247 760979
SGTC_1426 4048-4480 71.7 µM 1.91393229812647 0.0331244930484427 no 198 0.0278144034377385 221 14224343
SGTC_295 k015-0027 31 µM 1.89574725495546 0.0344323861874328 no 199 0.0289967367248177 229 3887424
SGTC_2603 homopterocarpin 100 µM 1.89356823877475 0.0345919126017074 no 200 0.0291411713162942 289 101795 A weak amylase inhibitor.
SGTC_2358 9037157 4 µM 1.88965933828618 0.0348796054888184 no 201 0.0294017677954788 263 2388925
SGTC_1680 diphenhydramine 100 µM 1.88963110035566 0.0348816909088142 no 202 0.0294036573631688 271 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_793 0488-0545 106 µM 1.87718062507865 0.035811201691268 no 203 0.0302466710325707 250 292548
SGTC_662 k832-1615 104 µM 1.87574345385029 0.0359197907006023 no 204 0.0303452579753632 249 5878478
SGTC_291 SEC14.278 35.5 µM 1.86945379041585 0.0363981994830729 no 205 0.0307798534429946 233 1068044
SGTC_964 1287-0107 19.4 µM 1.86722676471292 0.0365688381710414 no 206 0.0309349637456416 297 51516812 YPR165W RHO1
SGTC_791 1348-1292 225 µM 1.86083029156981 0.0370625897772909 no 207 0.0313840731654138 342 5437054
SGTC_898 1000-0849 28.3 µM 1.84232551048885 0.0385217494787215 no 208 0.0327137752048089 224 6751807
SGTC_1457 k015-0032 57.3 µM 1.83028489856774 0.0394960889534489 no 209 0.0336036741706186 300 4302660
SGTC_1292 0kpi-0043 232 µM 1.8287962407428 0.0396179331387483 no 210 0.0337150691813899 258 3333905
SGTC_745 0469-0705 296 µM 1.82567093906344 0.0398747284946297 no 211 0.0339499215780533 316 3486736
SGTC_3235 9132602 49.47 µM 1.81966697394922 0.0403718494429136 no 212 0.0344048678254497 302 4912240
SGTC_722 3534-0461 190 µM 1.81601763202367 0.040676461750198 no 213 0.0346838337282828 298 658262
SGTC_1865 st057639 52.2 µM 1.81575041717733 0.0406988393942724 no 214 0.0347043331582857 271 688818
SGTC_2166 5933061 31.504 µM 1.80341259193723 0.0417429861426391 no 215 0.0356617207608884 295 2877375
SGTC_2797 7859098 81.82 µM 1.79586150041149 0.042392664819885 no 216 0.036258273374305 305 972681
SGTC_734 2023-0417 80 µM 1.79405097240109 0.0425496480264396 no 217 0.0364025166985324 294 3935732
SGTC_1534 6-azauridine 81.6 µM 1.79376520391825 0.0425744686992292 no 218 0.0364253265002253 337 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3217 9129673 49.47 µM 1.79166258349943 0.042757453819992 no 219 0.0365935157759719 311 17248312
SGTC_2920 7982904 15.77 µM 1.78746143967327 0.0431249714673706 no 220 0.0369314695411239 275 6456808
SGTC_1545 lovastatin 49.4 µM 1.78307973127424 0.0435109992053927 no 221 0.0372866626668113 338 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2925 9010536 32.5 µM 1.78135218871608 0.0436639599503459 no 222 0.0374274668374665 378 2994177
SGTC_1920 st075728 45.7 µM 1.77886439204496 0.043884997454525 no 223 0.0376309985829208 305 3400306
SGTC_2406 ethylparaben 405.7 µM 1.77876683966495 0.0438936832121518 no 224 0.0376389979180928 270 8434 A possible steroid mimic.
SGTC_1414 3917-0015 5.4 µM 1.77527770755004 0.0442052573489565 no 225 0.0379260221912069 239 6618702
SGTC_775 4577-0580 57.3 µM 1.76975333319126 0.0447022191700014 no 226 0.0383841205128309 273 2006902
SGTC_710 3448-4187 58 µM 1.76788954258983 0.0448708936241073 no 227 0.0385396856894391 410 3946412
SGTC_491 tetrandrine 80.3 µM 1.7667482112591 0.04497443768476 no 228 0.0386352026920699 222 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2028 5153890 36.43 µM 1.76285437886418 0.0453291427566045 no 229 0.0389625265723331 294 2830968 YPR165W RHO1
SGTC_1258 0671-0043 57.1 µM 1.76097673545854 0.0455009873207294 no 230 0.0391211703540881 322 4298767
SGTC_2344 7990960 76.95 µM 1.75473896743182 0.0460756405845052 no 231 0.0396519837034679 291 140813
SGTC_1559 coumarin 343 70.1 µM 1.75323505168647 0.0462150571649721 no 232 0.0397808343468295 247 108770 A hepatotoxic, DNA x-linker.
SGTC_1273 0849-0096 14.1 µM 1.74747440507232 0.0467522196722782 no 233 0.0402775404401051 303 5286025
SGTC_2687 chenodiol 100 µM 1.74745436990324 0.0467540965930752 no 234 0.0402792767025061 275 5702181 A cholesterol synthesis inhibitor.
SGTC_1425 4048-4433 7.33 µM 1.74328538305373 0.0471459695863134 no 235 0.0406418886580061 332 23734946
SGTC_2795 7780010 54.55 µM 1.74283100915079 0.0471888381086774 no 236 0.0406815690031547 306 953673
SGTC_438 sphingosine 6.67 µM 1.73484774790139 0.0479471391479689 no 237 0.0413838881550539 247 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1749 st037932 54.2 µM 1.73464830614076 0.0479662075531178 no 238 0.041401558863498 311 594497
SGTC_776 4476-4378 112 µM 1.73436634553236 0.0479931758498544 no 239 0.041426551244448 271 2892008
SGTC_1020 4335-0961 93.3 µM 1.73300686348713 0.0481233747140051 no 240 0.0415472244434432 289 669075
SGTC_2030 5175110 200 µM 1.72686667295608 0.0487149513951566 no 241 0.0420958054947789 291 2831986
SGTC_3137 9097352 49.47 µM 1.72332582458338 0.0490587281833904 no 242 0.0424148101181466 365 44120435
SGTC_653 0203-0016 55.2 µM 1.72149073078475 0.0492376561926154 no 243 0.0425809063749949 312 295302
SGTC_801 0866-0028 10.1 µM 1.71728318441836 0.0496498738734871 no 244 0.0429637214733915 360 6849771
SGTC_1274 0865-0114 173 µM 1.71433693493544 0.0499401567798328 no 245 0.0432334317594229 329 870624
SGTC_1859 st055998 20 µM 1.71297917881747 0.0500743862205418 no 246 0.0433581850797931 326 676301
SGTC_425 3825-7017 13.1 µM 1.70418138173721 0.0509511313519749 no 247 0.0441736031951684 364 3397440
SGTC_247 mechlorethamine 29.705 µM 1.70187714498196 0.0511827681397414 no 248 0.04438920049741 251 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2589 lobaric acid 100 µM 1.69941600250105 0.0514311027500363 no 249 0.0446204144547783 330 73157 A novel microtubule depolymerizer.
SGTC_2932 9016711 44.54 µM 1.69398940849055 0.0519820436428028 no 250 0.045133647847727 369 7117328
SGTC_195 4234-0266 16.654 µM 1.69112562794446 0.0522746766475447 no 251 0.0454064057311993 381 2303354
SGTC_2277 7947813 106.88 µM 1.68986992623069 0.0524034013413006 no 252 0.0455264211292298 334 1246798
SGTC_1115 galangin 695.678 nM 1.68805578170637 0.0525898174856087 no 253 0.0457002607681594 363 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1501 4491-0275 38.4 µM 1.68660179463755 0.0527396045331534 no 254 0.0458399733288819 291 5104718
SGTC_1396 3511-0007 98.6 µM 1.68324873195662 0.053086321245031 no 255 0.0461634752967917 298 X1396
SGTC_140 0062-0056 502.533 µM 1.6816083365249 0.0532566001753237 no 256 0.0463224064952195 365 3758964
SGTC_2648 atorvastatin 78.68 µM 1.68048612473223 0.0533733389828194 no 257 0.0464313858543584 284 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1050 3232-1156 69.3 µM 1.67818013277327 0.0536138577510068 no 258 0.0466559694957478 339 700529
SGTC_1255 0566-0045 221 µM 1.66887158552557 0.0545934939906824 no 259 0.047571415958085 360 2788469
SGTC_1687 st020778 55.3625 µM 1.66748003432011 0.0547411500837709 no 260 0.047709495612325 520 4259299
SGTC_1880 MG-132 525 µM 1.66711062886258 0.0547804003058498 no 261 0.0477462045205756 295 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2022 5136654 200 µM 1.66560722050394 0.0549403706318672 no 262 0.0478958360272893 356 1713771
SGTC_815 1582-0027 36.9 µM 1.65530430464362 0.0560466083417637 no 263 0.0489313931005714 340 3128206
SGTC_1284 0929-0043 16 µM 1.65368045435717 0.0562225548792201 no 264 0.0490962280174163 369 1239883
SGTC_2605 digitonin 300 nM 1.64314665237174 0.057374504604298 no 265 0.050176297211911 412 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_330 1488-0319 80.1 µM 1.63796392862361 0.0579480496262045 no 266 0.0507146093350056 337 6846614
SGTC_2815 7968870 71.43 µM 1.63745942492844 0.0580041202578009 no 267 0.0507672551569794 400 2977326 YHR190W ERG9
SGTC_3338 9144300 39.5675 µM 1.63659983647027 0.0580997532798071 no 268 0.0508570549122761 356 4901274
SGTC_1322 1348-1070 12 µM 1.63507577869158 0.0582696159793825 no 269 0.0510165815013027 273 6758089
SGTC_2665 lovastatin 100 µM 1.63354873532602 0.0584402024489767 no 270 0.0511768197971735 325 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_467 ro 31-8220 72.8 µM 1.63285832984889 0.0585174564756524 no 271 0.0512493979305641 415 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3275 9138069 49.47 µM 1.63194544916686 0.058619727804281 no 272 0.0513454892270305 315 17617007
SGTC_607 4491-0986 66.8 µM 1.6313429085579 0.0586873081284915 no 273 0.051408992102801 365 698981 YDR232W HEM1
SGTC_56 0957-0365 83.25 µM 1.63053348364631 0.0587781886196073 no 274 0.0514943972031587 385 6752360
SGTC_2312 7706453 155.7 µM 1.63031141988539 0.0588031407596556 no 275 0.0515178475981001 369 976098
SGTC_1150 3909-7983 10.9 µM 1.62069644333173 0.0598915188386676 no 276 0.052541378397004 396 23965914
SGTC_127 0180-0333 59.125 µM 1.61921961015384 0.0600600796425546 no 277 0.0527000100615714 465 771601
SGTC_3310 9130229 44.1445 µM 1.60973622952581 0.0611513476299036 no 278 0.0537277260665264 357 7761258
SGTC_2365 9042475 200 µM 1.60759443039154 0.0613999399814204 no 279 0.0539620164193348 386 6464479
SGTC_2558 carylophyllene oxide 100 µM 1.60530356475112 0.0616667070547608 no 280 0.0542135075330003 389 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1246 0422-0085 105 µM 1.60401116041248 0.0618176039414283 no 281 0.0543557962969592 403 264295
SGTC_424 splitomicin 100 mM 1.60160043859853 0.0620998419577567 no 282 0.0546219968865413 355 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2495 cafestol 54.53 µM 1.59779562397688 0.062547339274752 no 283 0.0550442344325824 364 16667697 An anti-infammatory.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.59745113055506 0.0625879801213169 no 284 0.0550825914019578 443 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2461 5755302 26.15 µM 1.59725803076341 0.0626107696417525 no 285 0.0551041009676367 403 2788904
SGTC_628 1636-0253 16 µM 1.59272380654373 0.063147757288491 no 286 0.0556110822360275 403 4456143
SGTC_1558 st069300 45.6 µM 1.58931721810219 0.0635535534567027 no 287 0.0559943966913142 272 24208000
SGTC_1892 st058411 7.36 µM 1.58589985972219 0.0639626685514078 no 288 0.0563810138302787 443 3934738
SGTC_348 k064-0012 10.7 µM 1.58533941236943 0.0640299585345872 no 289 0.056444619459776 337 5066323
SGTC_2944 9067346 25.62 µM 1.58478004609625 0.0640971735874223 no 290 0.0565081587718284 413 6473075
SGTC_3029 9088683 49.47 µM 1.58115250178735 0.0645344018742422 no 291 0.0569215863599005 353 25236615
SGTC_1167 k781-0610 148 µM 1.5805397344869 0.0646084869833181 no 292 0.0569916573954992 423 4525169
SGTC_916 4466-0038 42 nM 1.57691964304034 0.0650475138624581 no 293 0.0574070080576952 509 5722064 YGL116W CDC20
SGTC_206 4546-0025 72.014 µM 1.56551342980668 0.0664459531575537 no 294 0.0587312854597977 463 6620745 YIL048W NEO1
SGTC_1002 4049-0206 172 µM 1.56308056251704 0.0667472208222459 no 295 0.0590168234463244 439 4662749
SGTC_2960 9079389 5.97 µM 1.56035605488709 0.0670858564438637 no 296 0.0593378817951 396 16457355
SGTC_778 3456-2434 196 µM 1.55683571890264 0.0675253730997065 no 297 0.0597547471791412 496 5539063
SGTC_1730 st033808 45.1 µM 1.55606117901856 0.0676223729839272 no 298 0.0598467725924298 450 1045166
SGTC_1232 0279-0259 161 µM 1.55564408994892 0.0676746519158928 no 299 0.0598963741661886 406 1560000
SGTC_1213 1315-0166 115 µM 1.55309120010336 0.0679953178694887 no 300 0.0602006740675121 344 768401
SGTC_692 k241-0027 77.8 µM 1.55060229866101 0.0683090744891879 no 301 0.0604985104750526 371 3600480
SGTC_1703 st026983 48.3 µM 1.54877835292269 0.0685397137755063 no 302 0.0607175055037633 401 1104023
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.54607912281564 0.0688821350693098 no 303 0.0610427300666801 442 5379071
SGTC_2913 7966556 36.57 µM 1.54564931426648 0.0689367816063862 no 304 0.0610946422371654 352 2976516
SGTC_1979 st071809 45.3 µM 1.54478221635562 0.0690471275086957 no 305 0.0611994751242405 383 4976333
SGTC_3252 9135871 49.47 µM 1.54252708428532 0.0693347504618002 no 306 0.0614727807666177 387 17682838
SGTC_2707 st078556 66.6 µM 1.54213521330841 0.0693848242635921 no 307 0.0615203697567347 363 17250899
SGTC_3233 9132340 49.47 µM 1.53857666097067 0.0698408166456284 no 308 0.0619538399688337 397 17682950
SGTC_2254 7938975 95.19 µM 1.53218455229106 0.0706656881356215 no 309 0.0627384497215171 494 2969277
SGTC_1355 1499-0035 1.68 µM 1.52937039029446 0.0710312075499656 no 310 0.0630863242557124 401 1548538
SGTC_2221 6807166 181.081 µM 1.52840842815868 0.0711564851342372 no 311 0.0632055817765431 301 674925
SGTC_2870 9038528 12.99 µM 1.52827454743176 0.0711739340366886 no 312 0.0632221933047081 366 6463316
SGTC_435 c-PAF 6.7 µM 1.52736185648274 0.0712929741497641 no 313 0.0633355279161998 421 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1607 st000305 50.6 µM 1.52501746752273 0.0715994477224841 no 314 0.0636273704545236 416 5457690
SGTC_843 0310-0051 143 µM 1.52084861366203 0.0721469225821537 no 315 0.0641489158520987 399 2065037
SGTC_203 k066-0004 30.888 µM 1.52066255583001 0.0721714312257383 no 316 0.0641722698980827 507 6795412
SGTC_143 4032-1194 15.74 µM 1.51974254187223 0.0722927147360494 no 317 0.0642878475320461 508 1806963
SGTC_393 acivicin 6.25 µM 1.51957922626386 0.0723142606042839 no 318 0.0643083811089367 376 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1568 digitonin 820 nM 1.51724941254183 0.0726221638465255 no 319 0.0646018625297592 458 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3131 9127911 49.47 µM 1.5151906923359 0.0728950746737317 no 320 0.0648620597497614 404 45595681
SGTC_2081 5214970 32.255 µM 1.51510113621425 0.0729069643271245 no 321 0.0648733969954338 389 2063512
SGTC_2382 9035899 200 µM 1.51418074585903 0.0730292432688609 no 322 0.0649900018376552 419 6462679
SGTC_84 0443-0269 128.823 µM 1.51409758890396 0.0730402988561542 no 323 0.0650005450534994 426 6150058
SGTC_837 0091-0265 12.5 µM 1.50908585169709 0.0737089691052305 no 324 0.0656384223431935 434 759367
SGTC_3356 9151811 4.48 µM 1.50196660583953 0.0746668566149129 no 325 0.0665528666892985 406 1859254 YPR165W RHO1
SGTC_1304 1165-0502 251 µM 1.48651646673143 0.076778301206519 no 326 0.0685712822957296 498 767425
SGTC_422 cantharidin 155 µM 1.48643964813025 0.0767889116380327 no 327 0.0685814345905765 467 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2748 diazoxide 86.69 µM 1.47892896852939 0.0778317031263462 no 328 0.0695796500435921 361 3019 A potassium channel activatior.
SGTC_1861 st057647 17.4 µM 1.47773199193868 0.0779988809925229 no 329 0.0697397639027516 431 688668
SGTC_3199 9111318 49.47 µM 1.47756426541125 0.0780223285635839 no 330 0.0697622225184271 416 8548020
SGTC_282 k297-0036 65.7 µM 1.4765242980607 0.0781678316865922 no 331 0.0699015986432798 377 5061378
SGTC_9 0092-0002 10.449 µM 1.47178376313017 0.0788336942396706 no 332 0.0705396397903913 446 759368
SGTC_902 1120-0002 2.07 µM 1.46915839949807 0.0792043009807505 no 333 0.0708949154137462 480 3280475
SGTC_88 0180-0332 8.668 µM 1.46838612403174 0.0793135691493181 no 334 0.0709996842983478 437 3101745
SGTC_1938 st074717 56.4 µM 1.46680562310978 0.0795375476859154 no 335 0.0712144698030987 371 17250979
SGTC_1649 st011737 51.3 µM 1.46611315427481 0.0796358306182406 no 336 0.0713087313331713 426 1761035
SGTC_2257 7960413 200 µM 1.46571430764215 0.0796924810863272 no 337 0.0713630673285044 509 2974689 YIL048W NEO1
SGTC_975 1335-0046 28.5 µM 1.46521338500244 0.0797636731752943 no 338 0.0714313544379031 452 16486740
SGTC_25 0118-0223 35.662 µM 1.46362470913946 0.0799897770720802 no 339 0.0716482587226498 441 5333628
SGTC_2777 climbazole 1.536 µM 1.46332903178521 0.0800319119714564 no 340 0.0716886837077213 482 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1608 st001473 40.5 µM 1.46179181193251 0.0802512407980713 no 341 0.071899134289278 442 7292267
SGTC_2692 st077426 47.7 µM 1.45958744296632 0.0805665500886475 no 342 0.0722017462013254 463 25238571
SGTC_632 0781-2353 4.65 µM 1.45768940212975 0.0808387916897274 no 343 0.0724630872114456 483 6811515 YHR007C ERG11
SGTC_2520 obtusaquinone 4.71 µM 1.45512779668956 0.0812073107763008 no 344 0.0728169425689763 438 5967872
SGTC_2714 st079313 56.9 µM 1.45098021151088 0.0818066785415955 no 345 0.0733926852653338 427 2939799
SGTC_1009 4106-0057 9.87 µM 1.44863329139425 0.0821473060091287 no 346 0.0737200094500333 468 2928005
SGTC_283 0987-0079 11.7 µM 1.44737493017474 0.0823303815710855 no 347 0.0738959716362124 495 411556
SGTC_455 paf C-16 10 µM 1.44111884591222 0.0832451254908454 no 348 0.0747755550939764 424 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_932 2857-0803 154 µM 1.437490590337 0.0837791263281692 no 349 0.0752893223084461 487 674898
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.43055843927542 0.084806537123492 no 350 0.0762784029532209 544 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_155 k072-0202 43.6 µM 1.43005141376562 0.084882052267596 no 351 0.0763511316986338 414 5857737
SGTC_3095 9117207 49.47 µM 1.42774667254278 0.0852259502972684 no 352 0.0766823935455653 378 17015229
SGTC_840 0245-0196 390 µM 1.40993042258956 0.0879196732508653 no 353 0.0792801142620726 521 3827528
SGTC_674 0498-0004 451 µM 1.40717197070093 0.0883423512477014 no 354 0.0796882004648521 471 4231473
SGTC_502 l-744,832 89.3 µM 1.39964253149874 0.0895037940944123 no 355 0.080810195480517 486 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_416 estradiol valerate 100 µM 1.39720503264721 0.0898822096910914 no 356 0.0811759618877095 459 13791 A steroid.
SGTC_3303 9125618 40.5795 µM 1.39719450061184 0.08988384733928 no 357 0.0811775450107003 576 22695467
SGTC_683 panaxydol 45 µM 1.39710613761504 0.0898975879598435 no 358 0.081190828213024 501 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_567 1080-0542 68.4 µM 1.39455126151131 0.0902955516415631 no 359 0.081575600560918 435 5950415
SGTC_2156 5649887 115 µM 1.39324910589917 0.0904988863313137 no 360 0.0817722374854792 558 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2472 5377652 49.4 µM 1.39190346081084 0.0907093689686683 no 361 0.0819758168612615 542 1610903
SGTC_249 wiskostatin 11.211 µM 1.39008673198087 0.0909941134858781 no 362 0.0822512708853605 468 2775510 A n-wasp and actin depolymerizer.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.38946972725525 0.0910909702348814 no 363 0.0823449800882275 498 5393153
SGTC_1844 rapamycin 4 nM 1.38945906081163 0.0910926453140093 no 364 0.082346600788818 632 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2984 9022109 38.96 µM 1.38872229449957 0.0912084038295015 no 365 0.0824586060443261 416 6459207
SGTC_3102 9121669 49.47 µM 1.38825092319451 0.0912825214728497 no 366 0.0825303253566841 430 41905072
SGTC_1499 4480-0877 67.3 µM 1.38592951227727 0.0916481878521273 no 367 0.0828842140620199 425 2861909
SGTC_2320 7373003 200 µM 1.38334454216063 0.0920566457362427 no 368 0.083279623231231 468 5415828
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.37523396564051 0.0933469669392246 no 369 0.0845294606407511 534 1273210
SGTC_3087 9117406 49.47 µM 1.37404888415501 0.0935366162527465 no 370 0.0847132533993107 470 42546093
SGTC_1176 0848-0131 83.3 µM 1.36888962854747 0.0943655716273208 no 371 0.0855168891090975 558 6769040
SGTC_2526 patulin 37.61 µM 1.36542647043104 0.0949250400761026 no 372 0.0860595244535373 581 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_644 1498-1197 63.3 µM 1.36423111461425 0.0951187143676251 no 373 0.0862474191867699 545 6741615
SGTC_1010 4112-3296 15.2 µM 1.3614166954975 0.0955758619549424 no 374 0.0866910214769056 542 704384
SGTC_116 0155-0182 31.788 µM 1.35907862296598 0.09595686416368 no 375 0.087060837992073 645 771486
SGTC_2750 bromebric acid 70.15 µM 1.35875974835067 0.0960089130285499 no 376 0.0871113660489574 574 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1739 st037196 92.5 µM 1.35619423534473 0.0964284289722213 no 377 0.0875186878529149 526 612214
SGTC_1983 st071813 46.9 µM 1.35580344438577 0.0964924496401972 no 378 0.0875808575583665 514 11838595
SGTC_3308 9128332 17.569 µM 1.35123908651715 0.097242511550255 no 379 0.0883094287905506 606 17332805 YDL196W YDL196W
SGTC_3221 9128209 49.47 µM 1.3504984109852 0.0973646292714115 no 380 0.0884280815154236 462 16460723
SGTC_2580 diallyl disulphide 81.36 µM 1.34867561189861 0.0976656394708086 no 381 0.0887205911450917 486 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_501 nsc-95397 161 µM 1.34597554493224 0.0981127714830436 no 382 0.089155201746656 486 262093
SGTC_2073 5212005 126 µM 1.34205313431009 0.0987649931913558 no 383 0.089789384019412 411 691789
SGTC_3321 9137793 26.8275 µM 1.34008590970363 0.0990932971679834 no 384 0.0901087082116433 543 4904192
SGTC_3327 9140648 26.9345 µM 1.33889090416048 0.0992931172142646 no 385 0.0903030956010993 500 8029710
SGTC_1967 st070177 51.4 µM 1.33474411813855 0.0999887970300937 no 386 0.0909800543658776 486 5729214
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.33462759268997 0.100008397045131 no 387 0.0909991312623246 464 279621
SGTC_1783 st039459 87.517 µM 1.33088765946837 0.100638958588967 no 388 0.0916129891876003 575 729761
SGTC_2196 6573537 42.6665 µM 1.32920701664563 0.100923261417687 no 389 0.0918898404016146 489 2903087
SGTC_3335 9143315 29.6265 µM 1.3291240849605 0.100937305546849 no 390 0.0919035177099613 509 4899691
SGTC_57 miconazole 162.5 nM 1.32845475952506 0.101050705126877 no 391 0.0920139597886968 501 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2198 6589944 200 µM 1.3266852091181 0.101350956098743 no 392 0.0923064178629665 417 5290268
SGTC_1085 doxorubicin 7.67 µM 1.32606096684078 0.101457030216615 no 393 0.0924097519448492 573 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1068 loratadine 26.9 µM 1.32385823779471 0.101831974128864 no 394 0.0927750651170471 505 3957 A H1 histamine antagonist.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.31916242633436 0.102634650158839 no 395 0.093557408369033 521 140250 A respiratory chain inhibitor.
SGTC_2010 4012422 159 µM 1.31265802754199 0.103754058809451 no 396 0.0946491034179789 544 952393
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.31013312519418 0.104190973014462 no 397 0.0950754020632776 518 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_269 exalamide 29 µM 1.30916310984375 0.104359180555109 no 398 0.0952395526626857 509 3316 A derivative of salicylamide.
SGTC_564 3555-0129 330 µM 1.30694181575542 0.104745109810603 no 399 0.0956162365038299 436 563260
SGTC_1876 myriocin 605 nM 1.30558074491279 0.104982093342715 no 400 0.0958475859469475 531 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3176 9106582 49.47 µM 1.30509243487882 0.105067210220808 no 401 0.0959306872337703 360 17018027
SGTC_1288 0973-0013 65.5 µM 1.29892270583137 0.106146955079756 no 402 0.0969852282697335 567 4315430
SGTC_2766 oltipraz 83.91 µM 1.29892147149304 0.106147171896452 no 403 0.0969854400930482 532 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.29638038650455 0.106594202642781 no 404 0.0974222329685616 607 165506
SGTC_2385 9074692 200 µM 1.29546584850024 0.106755421366705 no 405 0.0975797875822407 558 17046906
SGTC_1797 st048695 56.8 µM 1.29269355219587 0.107245208765339 no 406 0.0980585343523267 548 592262 YIL048W NEO1
SGTC_1556 plumbagin 1.48 µM 1.29096346316162 0.107551687101436 no 407 0.0983581736033951 479 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_723 4182-0001 115 µM 1.28826997775897 0.108030082580579 no 408 0.0988260000315115 520 744821 YLR208W SEC13
SGTC_738 1315-0003 72.4 µM 1.28252183650821 0.109056141322184 no 409 0.0998298249152989 585 6251474
SGTC_2178 5812956 200 µM 1.28081828159454 0.109361571658483 no 410 0.100128750585172 511 5403383
SGTC_53 0973-0023 39.979 µM 1.27936975420015 0.109621761083469 no 411 0.100383439766407 532 674768
SGTC_1453 4237-0541 195 µM 1.27551222788267 0.110316830201737 no 412 0.101063999449079 571 739892
SGTC_1702 st027038 51 µM 1.27218035737312 0.110919722978339 no 413 0.10165452252061 599 5521182
SGTC_2895 9054447 58.44 µM 1.27174201114582 0.110999215868622 no 414 0.101732399306999 527 2697450
SGTC_1031 k035-0009 16 µM 1.26890480461163 0.111514722404326 no 415 0.102237509255157 627 5180959
SGTC_2056 5235370 200 µM 1.26340217449889 0.112519402050468 no 416 0.103222341539934 561 5511916
SGTC_1643 st009866 20.2 µM 1.26334030382579 0.112530735143383 no 417 0.103233453858922 542 3156273 YOR207C RET1
SGTC_1149 3909-7961 23.3 µM 1.26259304844393 0.112667677227785 no 418 0.103367733711131 564 735261
SGTC_1278 0874-0585 172 µM 1.2596460327822 0.113208907655218 no 419 0.103898540838402 579 766306
SGTC_2545 solidagenone 89.61 µM 1.25846115858701 0.113427036213541 no 420 0.104112512889931 352 6708572 An anti ulcer agent
SGTC_1511 0906-3109 28.5 µM 1.2570012576998 0.113696207566659 no 421 0.104376590080633 674 2882180
SGTC_2058 5236698 133 µM 1.25448450311492 0.114161306343805 no 422 0.104832977483056 563 766665
SGTC_1237 0330-0133 46.1 µM 1.25425536131136 0.114203719186918 no 423 0.104874601633821 524 X1237 YHR072W ERG7
SGTC_1929 genistein trimethyl ether 50.5 µM 1.25125987066329 0.114759199914907 no 424 0.10541984060457 578 136420
SGTC_270 tamoxifen 5.46 µM 1.25100481381286 0.114806586051284 no 425 0.105466360582935 627 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2380 9035439 200 µM 1.24485332643122 0.115953668584754 no 426 0.10659283499575 631 6462575
SGTC_2525 harmine 47.85 µM 1.24223930090827 0.116443567596668 no 427 0.107074141631486 520 5280953 A monoamine oxidase inhibitor
SGTC_1525 8-methoxypsoralen 92.5 µM 1.2414523095345 0.116591346142675 no 428 0.107219352690903 654 4114 Related to psoralen; DNA damaging agent.
SGTC_2007 4011539 71.82 µM 1.23672601871481 0.117481630840821 no 429 0.108094407898449 597 45595301
SGTC_2360 9040895 200 µM 1.23351655842201 0.118088929842684 no 430 0.108691551404118 548 4914414
SGTC_3090 9117696 49.47 µM 1.23101893093695 0.118563068578058 no 431 0.109157891999514 567 7923821
SGTC_2167 5876490 200 µM 1.22758004307957 0.119218091029661 no 432 0.109802328637155 599 686534
SGTC_1144 3486-0183 12.5 µM 1.22664972478052 0.119395731629096 no 433 0.109977135688251 656 6744069
SGTC_989 1501-0895 10.3 µM 1.22645439478553 0.119433052830805 no 434 0.110013863596184 595 2830112
SGTC_1411 3909-8223 150 µM 1.22491483773269 0.1197275001775 no 435 0.110303654648241 617 X1411
SGTC_328 k915-0120 63.5 µM 1.22487416272802 0.119735286393622 no 436 0.110311318325791 595 6624543
SGTC_1393 3470-5649 58.2 µM 1.22406296117191 0.119890645295977 no 437 0.110464238554128 495 4108395
SGTC_896 0964-0007 44.5 µM 1.22398606665873 0.119905379274332 no 438 0.11047874187988 621 6756758
SGTC_2331 7980721 200 µM 1.2195727419418 0.120753169101131 no 439 0.111313442397319 611 2981221
SGTC_175 3793-3120 23.7 µM 1.21710158514467 0.121229711304956 no 440 0.111782783840263 553 5322297
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.21660836736584 0.121324982405558 no 441 0.111876628820414 653 1377
SGTC_1507 4075-3230 155 µM 1.21504090674639 0.121628106245961 no 442 0.112175244946935 540 659771
SGTC_851 0394-0702 453 µM 1.21357072435874 0.121912901269612 no 443 0.112455846007697 668 762646
SGTC_2407 paclitaxel 400 µM 1.21249371268196 0.122121830638539 no 444 0.112661723939078 646 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1999 st074831 12.5 µM 1.20891719674432 0.122817441747126 no 445 0.113347329357049 635 17112523
SGTC_3189 9110682 49.47 µM 1.206828524252 0.123224958972249 no 446 0.113749094259861 600 17122418
SGTC_763 3453-1109 128 µM 1.20036004329103 0.124493020746149 no 447 0.114999769938274 649 1560353
SGTC_1521 st012942 49.4 µM 1.19962185898891 0.12463831011019 no 448 0.115143116593721 673 24207259
SGTC_1651 st011928 86.1 µM 1.19942604670279 0.124676869746784 no 449 0.115181162332469 627 720198
SGTC_168 3970-0862 530.542 µM 1.19865587283683 0.124828614378118 no 450 0.115330891506437 789 3135186
SGTC_2110 5483698 200 µM 1.19734553514491 0.12508708203565 no 451 0.115585951507972 619 2848765 YHR062C RPP1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.19608782776308 0.125335519559034 no 452 0.115831143585128 593 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_313 3474-0040 5.03 µM 1.19498953597267 0.125552748956765 no 453 0.116045559241876 667 1043375 YIL048W NEO1
SGTC_1856 st057054 55.7 µM 1.19244085504354 0.126057860389507 no 454 0.116544214414195 661 1266018
SGTC_1839 st053978 48 µM 1.19177686286415 0.126189686275698 no 455 0.116674375145333 618 3788398
SGTC_941 3237-0776 460 µM 1.19121674766858 0.126300963606056 no 456 0.116784253251185 594 760008
SGTC_2654 protoveratrine a 100 µM 1.18991400911783 0.126560041345892 no 457 0.117040095858807 619 5702278 A heart drug and vasodilator.
SGTC_1645 Cervolide 78 µM 1.18429701670703 0.127681339613797 no 458 0.118147754680005 583 23173 A fragrance.
SGTC_725 1497-0963 19 µM 1.18320319643233 0.127900495558739 no 459 0.118364313244402 653 3549977
SGTC_2134 5324836 1.464 µM 1.18168702210788 0.128204705676385 no 460 0.118664954837914 558 699272
SGTC_2915 7971052 15.16 µM 1.18078184036219 0.128386563631133 no 461 0.118844699956046 465 5741558
SGTC_870 0573-2213 57.6 µM 1.17670769076338 0.129207308185595 no 462 0.119656098569107 620 3916321
SGTC_1613 st002381 52.1 µM 1.1734312695264 0.129869982233304 no 463 0.120311451892324 626 551167
SGTC_2986 9022445 71.43 µM 1.17322630955919 0.129911514567383 no 464 0.120352532078678 631 6459286
SGTC_2994 9053520 71.4286 µM 1.17269743432403 0.13001872637351 no 465 0.120458580336009 646 4647384
SGTC_819 1013-0258 27.7 µM 1.17242565075435 0.130073845239176 no 466 0.120513103041655 642 5753198
SGTC_2677 mitomycin C 100 µM 1.16986578586053 0.130593790275397 no 467 0.121027492243896 603 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3211 9128781 49.47 µM 1.16885585112417 0.130799317205039 no 468 0.121230856779553 639 17194361
SGTC_1650 st011916 45.8 µM 1.16384952640222 0.131821430424066 no 469 0.12224249862777 627 242528
SGTC_2125 5246583 200 µM 1.16101717537593 0.13240212995227 no 470 0.12281745739765 740 835267
SGTC_1441 4106-0040 13 µM 1.16036718385636 0.132535642049517 no 471 0.122949670842223 627 2904180
SGTC_2123 5259487 200 µM 1.16007681074115 0.13259531636762 no 472 0.123008767278735 690 2173474
SGTC_1690 st023502 41.2 µM 1.15766823649412 0.133091013838904 no 473 0.123499725502101 641 24207482
SGTC_2519 cryptotanshinone 88.04 µM 1.15551506019613 0.13353522754397 no 474 0.123939784493962 642 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2176 5809774 33.9695 µM 1.15537190509219 0.133564797441853 no 475 0.12396908091418 699 2870539
SGTC_2881 9058953 51.95 µM 1.15485610612947 0.133671377420629 no 476 0.124074678379673 680 17122249
SGTC_806 3966-4455 5.86 µM 1.15432810127072 0.133780540064822 no 477 0.124182839881079 581 714982
SGTC_2104 5389443 200 µM 1.15144049953517 0.134378622692574 no 478 0.124775530216945 705 2244536
SGTC_974 1326-0144 138 µM 1.14773649028725 0.135148484716526 no 479 0.125538681197546 695 5411856
SGTC_67 0335-0847 266 µM 1.14674895526926 0.135354249152775 no 480 0.125742695582239 807 4552207 YOR254C SEC63
SGTC_1751 st044839 27.194 µM 1.14564255559588 0.135585035353964 no 481 0.125971540741185 656 5291326
SGTC_3248 9135562 49.47 µM 1.14556248426505 0.135601748054089 no 482 0.125988113772802 715 17650701
SGTC_445 e6 berbamine 66 µM 1.14231466205174 0.136280831918599 no 483 0.12666162444079 779 6610268 A calcium/calmodulin antagonist.
SGTC_3151 9099821 49.47 µM 1.14033636703142 0.136695610107357 no 484 0.1270730961235 649 17174189
SGTC_2616 abietic acid 100 µM 1.13957817819241 0.136854803922323 no 485 0.12723104045914 724 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_232 clozapine 119 µM 1.13927415936185 0.136918673094147 no 486 0.12729441138116 655 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1044 1222-0021 1.78 µM 1.13725589536995 0.137343192424898 no 487 0.127715663238871 678 4306703
SGTC_219 mitoxanthrone 164.414 µM 1.13534859260668 0.137745197556802 no 488 0.12811464490778 654 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_277 nystatin 15.5 µM 1.1348961609693 0.137840674971609 no 489 0.1282094143235 694 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1141 3253-0389 52.6 µM 1.12991081905599 0.13889573008432 no 490 0.12925690232315 672 5402031
SGTC_2068 5226020 147 µM 1.12970748009652 0.138938879403817 no 491 0.129299752143295 711 1810509
SGTC_737 1950-0117 57.9 µM 1.1278939901794 0.139324112700219 no 492 0.129682346135123 672 5393513
SGTC_2663 amphotericin b 100 µM 1.12397891507223 0.140158254413676 no 493 0.13051098545575 628 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3041 9091929 49.47 µM 1.12337706193602 0.140286784823328 no 494 0.130638693763233 705 25236887
SGTC_506 n9-isopropylolomoucine 153 µM 1.12107521771299 0.140779099915501 no 495 0.131127923254327 695 6610355
SGTC_630 4356-0227 183 µM 1.1204835787349 0.140905827949795 no 496 0.131253873235756 662 779312
SGTC_394 menadione 8.33 µM 1.11897200190766 0.141229956408234 no 497 0.131576041822597 717 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_441 propafenone 146 µM 1.11647199399399 0.141767143413599 no 498 0.132110075805689 630 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2980 9014342 25.29 µM 1.11336814935005 0.142436002573762 no 499 0.132775174213262 653 2996599
SGTC_2704 st078022 71.1 µM 1.11328181652372 0.142454637220943 no 500 0.132793706697711 700 54697681
SGTC_760 0568-0725 82.9 µM 1.11316397676347 0.142480075194165 no 501 0.132819005437805 741 3916171
SGTC_275 trichlorophene 5.69 µM 1.11309107041478 0.142495814966704 no 502 0.132834659191606 828 62616
SGTC_2428 5615643 7.78 µM 1.11095399902661 0.142957710413734 no 503 0.133294075189687 657 2253075
SGTC_395 anisomycin 6.25 µM 1.11073735082417 0.143004592043743 no 504 0.133340709999854 621 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2140 5586273 200 µM 1.10755080177911 0.143695346064146 no 505 0.134027930415956 649 854421
SGTC_1555 citronellol 128 µM 1.10705862867957 0.143802235721189 no 506 0.134134290471207 668 8842 A terpine precursor.
SGTC_1907 st060210 83.7 µM 1.10667751689169 0.143885042038369 no 507 0.134216689672309 771 688793
SGTC_1855 st056195 39.6 µM 1.10619149963719 0.143990688417235 no 508 0.134321820645315 684 4028379
SGTC_1320 1313-0481 95.3 µM 1.10532025790053 0.144180202603319 no 509 0.134510421503351 727 6813365 YLR208W SEC13
SGTC_2273 7815444 169.05 µM 1.10512528854527 0.144222635730922 no 510 0.134552652107356 675 2824616
SGTC_1437 4092-1038 11.6 µM 1.10391730917256 0.14448572800418 no 511 0.134814504807673 745 3977136
SGTC_537 1334-0398 209 µM 1.10029906028469 0.14527569974745 no 512 0.135600920728326 740 5846986
SGTC_973 1325-0077 65.9 µM 1.09566927567089 0.14629075062879 no 513 0.136611766503051 771 2835149
SGTC_3 0833-0587 95.581 µM 1.09417689737241 0.146618957675554 no 514 0.136938700891047 695 5382644
SGTC_1622 st003707 19.4 µM 1.09412484484838 0.146630414090011 no 515 0.136950113647179 750 10140899
SGTC_2484 5809818 12.04 µM 1.09332092286694 0.146807428258435 no 516 0.13712645979724 684 2870548
SGTC_1038 k292-0204 154 µM 1.09295404591572 0.146888257869258 no 517 0.137206988461357 670 4454212
SGTC_979 1426-2828 121 µM 1.09157709205183 0.147191891866177 no 518 0.137509514828816 760 747872
SGTC_3076 9116187 49.47 µM 1.09018104289556 0.147500165842411 no 519 0.137816701129829 654 27241210
SGTC_400 oxethazaine 37.5 µM 1.0899191805273 0.147558038133765 no 520 0.137874373366918 681 4621 A local anesthetic.
SGTC_1321 1326-2144 215 µM 1.08864199103607 0.147840518458561 no 521 0.138155895934959 701 3513030
SGTC_1171 0368-0077 21.4 µM 1.08824789797155 0.147927754404361 no 522 0.138242842380025 678 3239779
SGTC_1571 st070080 73.4 µM 1.08538066967113 0.148563477683106 no 523 0.138876545118817 712 4315245
SGTC_1792 st045773 43.6 µM 1.08494642358171 0.148659917980382 no 524 0.138972692564568 699 2919270
SGTC_1488 4013-0813 75.9 µM 1.08427945193804 0.148808125023565 no 525 0.139120456562058 678 2910057
SGTC_1676 st018489 23.4 µM 1.08312833486503 0.149064145698318 no 526 0.139375731851648 716 3696235
SGTC_3012 9080433 71.4286 µM 1.08178687687517 0.149362871232674 no 527 0.139673619560332 749 17688859
SGTC_2723 salbutamol 83.58 µM 1.08170020032189 0.149382186728511 no 528 0.139692882062964 620 9884233 β2-adrenoceptor agonist
SGTC_1989 st071868 50.2 µM 1.07861428849244 0.150070955389 no 529 0.140379854491311 736 16414057
SGTC_210 3551-0445 56.827 µM 1.0776807627257 0.150279732728174 no 530 0.140588123174891 723 2865180 YOR207C RET1
SGTC_1780 st038448 24.544 µM 1.07747240004001 0.150326358181046 no 531 0.14063463730153 725 728868 YDL195W SEC31
SGTC_585 0kpi-0023 191 µM 1.07521652545117 0.150831773797782 no 532 0.141138899223831 680 64601
SGTC_2981 9013952 38.96 µM 1.07267723564036 0.151402038776626 no 533 0.141707978799282 658 2996344
SGTC_2739 tacrine 100.86 µM 1.07170814351511 0.151620051664454 no 534 0.141925570977952 673 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3112 9123419 49.47 µM 1.07094901603527 0.151790975303769 no 535 0.142096177306185 764 17015854
SGTC_2444 5485484 36.41 µM 1.06914513575576 0.152197646837643 no 536 0.142502138043436 763 6790631
SGTC_1127 asiatic acid 681.4 nM 1.06831082965471 0.1523859794501 no 537 0.142690162507634 714 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2489 cantharidin 73.42 µM 1.06789585026236 0.152479712662074 no 538 0.142783747305785 731 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2780 5215298 71.43 µM 1.06749779337571 0.152569659458239 no 539 0.142873554774503 783 2834131
SGTC_2689 tacrolimus 100 µM 1.06737041047643 0.15259845092799 no 540 0.142902302285556 705 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3088 9117578 49.47 µM 1.06209309847144 0.153794413181831 no 541 0.144096711456526 733 678341
SGTC_1810 st050138 53 µM 1.05976420233552 0.154324163322761 no 542 0.144625943175185 719 3444541
SGTC_79 0052-0007 94.094 µM 1.05821910433513 0.154676289225395 no 543 0.144977781735862 749 2801472
SGTC_2831 7999036 19.48 µM 1.0562834081521 0.155118180592295 no 544 0.145419376969291 789 2988270
SGTC_1455 4262-0120 131 µM 1.0502158622535 0.156508709269271 no 545 0.146809439122575 787 1529587
SGTC_2785 7756463 72.73 µM 1.04942467276189 0.156690633004803 no 546 0.146991353781675 731 2201551
SGTC_1727 st034309 9.9045 µM 1.04589452799425 0.157504039219932 no 547 0.147804865521725 835 870305
SGTC_1996 st072960 66.8 µM 1.04511479105537 0.157684077532598 no 548 0.14798495936698 803 1719405
SGTC_2919 7978188 46.38 µM 1.04449202877937 0.157827968058718 no 549 0.148128902635323 778 2980291
SGTC_1886 st057356 49.9 µM 1.04224570420495 0.158347702323199 no 550 0.148648889123368 717 24207747
SGTC_2390 9097792 176.6 µM 1.04156496853543 0.158505426235879 no 551 0.148806708656331 720 4497149
SGTC_1343 1487-0095 224 µM 1.04138454095 0.158547247902206 no 552 0.148848557164243 767 4560101 YGL055W OLE1
SGTC_236 1509-0011 5.31 µM 1.03847978766264 0.159221542396551 no 553 0.149523370275978 985 3107280
SGTC_2189 6047310 154.431 µM 1.03836520658134 0.159248179109124 no 554 0.149550030788304 736 711535
SGTC_3231 9132313 49.47 µM 1.03819675507128 0.1592873444019 no 555 0.149589231531416 762 4905967
SGTC_2 0422-0095 29 µM 1.03656198200473 0.159667759832992 no 556 0.149970019525632 640 6790840
SGTC_496 calpeptin 138 µM 1.0349248784195 0.160049312876206 no 557 0.150351997558417 672 73364 A calpain inhibitor.
SGTC_1619 st003326 88.7 µM 1.03096052470714 0.160975736462903 no 558 0.151279665939483 731 2849032
SGTC_1724 st037281 8.293 µM 1.03055318821564 0.161071124183906 no 559 0.151375198890323 746 574124 YDL195W SEC31
SGTC_2418 pentamidine 31.67 µM 1.02971042852051 0.161268593887465 no 560 0.151572979336054 714 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1227 3909-8010 46.6 µM 1.02911506032934 0.161408191649385 no 561 0.151712804972348 764 15982272
SGTC_685 1278-0033 54.9 µM 1.02690820262353 0.161926327381786 no 562 0.15223184575078 789 3590572
SGTC_3026 9090633 49.47 µM 1.02620730092296 0.162091114626784 no 563 0.152396940361656 771 25236842
SGTC_2914 7968218 45.32 µM 1.02456227770872 0.162478300726078 no 564 0.152784885628412 743 2977111
SGTC_2996 9066192 71.4286 µM 1.02390796784831 0.162632471605343 no 565 0.152939373208639 747 6472854
SGTC_1366 1683-0113 21.9 µM 1.02368821417883 0.162684272109475 no 566 0.152991281962105 749 708623
SGTC_2850 9015429 58.44 µM 1.01531224930913 0.164666659754831 no 567 0.154978503597435 727 6457570
SGTC_3241 9133421 49.47 µM 1.01507000167952 0.164724225807093 no 568 0.155036230044436 785 17018221
SGTC_845 0330-0138 4.51 µM 1.0146144240385 0.164832521439361 no 569 0.155144830463147 782 9039800
SGTC_2888 9058547 12.99 µM 1.01435245511729 0.164894815105623 no 570 0.155207301248784 682 16476514
SGTC_1758 st042942 75.2445 µM 1.01134079153096 0.165612054431328 no 571 0.155926674412552 788 669317
SGTC_716 1683-5115 658 µM 1.01010737792692 0.16590637811306 no 572 0.156221923915813 880 723597
SGTC_2818 7996756 12.99 µM 1.0099312046103 0.165948445097836 no 573 0.15626412560492 714 2241621
SGTC_3078 9116413 49.47 µM 1.00959300209976 0.166029221024896 no 574 0.156345161853983 734 17177322
SGTC_370 0180-0345 38.7 µM 1.00930640362077 0.166097691783335 no 575 0.156413854992889 717 3989527
SGTC_577 r071-0003 38.6 µM 1.00828005488611 0.166343044649195 no 576 0.156660017629811 924 4568517 YMR134W ERG29
SGTC_401 neomycin 50 µM 1.00781356804269 0.166454637558774 no 577 0.156771985515699 771 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1078 idebenone 36.1 µM 1.00443661365114 0.167263912991908 no 578 0.157584104724375 830 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3180 9109287 49.47 µM 1.00223347290602 0.167793252707025 no 579 0.15811542239722 744 18891271
SGTC_1327 1436-0082 2.18 µM 1.00149343292048 0.167971300861461 no 580 0.158294156724289 795 15992205
SGTC_2426 5582046 32.21 µM 1.00085685228764 0.168124554713838 no 581 0.158448009589551 818 2251934
SGTC_1526 st051518 75 µM 0.998649095069719 0.168656758925631 no 582 0.158982354167653 731 673993
SGTC_2657 nystatin 74.44 µM 0.998334447713144 0.168732696204287 no 583 0.159058604446066 819 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1991 st073000 8.92 µM 0.998061543061918 0.168798577051164 no 584 0.159124758377377 844 4301969 YIL048W NEO1
SGTC_2859 9028643 45.46 µM 0.996042558624192 0.1692864855747 no 585 0.159614733676618 774 17151580
SGTC_2252 omeprazole 400 µM 0.9904083693037 0.170652828605771 no 586 0.160987278167613 730 4594 A proton pump inhibitor.
SGTC_1722 st034304 3.6505 µM 0.987219500224602 0.171429278608313 no 587 0.161767522073642 804 4036148 YLR033W RSC58
SGTC_2343 7990716 14.84 µM 0.985312240119327 0.171894750117768 no 588 0.1622353610975 826 6456862
SGTC_1345 1488-0192 31.4 µM 0.982855599549291 0.172495487283136 no 589 0.162839256465955 857 658348
SGTC_1221 2958-7315 257 µM 0.981791027794823 0.172756228770008 no 590 0.163101404617444 786 4562705
SGTC_2771 fluoxetine 41.05 µM 0.979265570184064 0.173375783729635 no 591 0.163724388807445 791 3386 A selective serotonin reuptake inhibitor.
SGTC_2860 9025725 38.96 µM 0.979218735555192 0.173387286723485 no 592 0.163735956623132 775 40546248
SGTC_475 α-linolenic acid 10 µM 0.978955766189155 0.173451883318308 no 593 0.163800918012957 870 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1071 trifluoperazine 6.31 µM 0.972595594083834 0.175018879030599 no 594 0.165377166635984 844 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2235 salicylic acid 500 µM 0.971576781979446 0.175270722246124 no 595 0.165630568927264 830 338 A COX inhibitor and kinase inhibitor.
SGTC_1223 0764-0573 147 µM 0.968558987396916 0.176018047559856 no 596 0.166382637244245 864 1609797
SGTC_1248 0469-0687 58.6 µM 0.966318784886291 0.176574113033432 no 597 0.166942344562698 846 4017482
SGTC_1827 berberine 7.24 µM 0.966263210742253 0.176587921814268 no 598 0.166956245001086 756 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2968 9090663 33.37 µM 0.962901476819382 0.177424498261664 no 599 0.167798484196015 825 25236811
SGTC_1371 2421-0008 32.7 µM 0.962132645109976 0.177616175052429 no 600 0.167991488795623 798 2827552
SGTC_1998 st075797 76.8 µM 0.961473583084966 0.177780589234755 no 601 0.168157050920332 921 24208315
SGTC_2857 9024691 58.44 µM 0.961378773241403 0.17780424905237 no 602 0.168180876613843 795 16478292
SGTC_3150 9097574 49.47 µM 0.961003714589877 0.177897864491565 no 603 0.168275150061837 831 17217476
SGTC_865 0488-0499 301 µM 0.959700753896923 0.178223327781537 no 604 0.168602921871651 909 9634651
SGTC_687 k029-0044 34.9 µM 0.957815203956883 0.178694978592455 no 605 0.169077975560338 911 5829338
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.956571833860343 0.179006424338452 no 606 0.169391705495546 919 368090
SGTC_2691 st077356 60.2 µM 0.955629540883448 0.179242682101646 no 607 0.169629715674973 887 2839272
SGTC_2075 5212009 200 µM 0.953638948926848 0.179742420502087 no 608 0.170133216585471 772 780898
SGTC_1931 st074438 57.1 µM 0.953273994815182 0.179834137150051 no 609 0.170225631970426 825 2787313
SGTC_2310 7668677 200 µM 0.951417429841386 0.180301165671186 no 610 0.170696257887201 818 2197143
SGTC_1243 0416-0003 5.65 µM 0.951278186774922 0.180336223640208 no 611 0.170731588550165 817 2141977
SGTC_185 k048-0037 25.491 µM 0.950762369301491 0.180466131022427 no 612 0.170862509623809 883 6827589
SGTC_378 3970-0959 8.33 µM 0.949532727277068 0.18077605008822 no 613 0.171174867524466 847 6615653
SGTC_748 act1.228 77.9 µM 0.94712109039316 0.181384847428008 no 614 0.171788539461136 870 4421505 YNR035C ARC35
SGTC_273 hydroxyurea 18.1 mM 0.946938969756315 0.181430874313237 no 615 0.171834939385773 929 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_634 1611-4317 11.2 µM 0.944080596941105 0.182154221286652 no 616 0.172564231860664 919 2843522
SGTC_2379 9035213 200 µM 0.943022556193644 0.182422428224132 no 617 0.172834682823436 918 646551
SGTC_2200 6600604 21.907 µM 0.940932269518382 0.182953027991304 no 618 0.173369784738321 865 2904777
SGTC_2853 9015042 58.44 µM 0.940276716873913 0.183119632094707 no 619 0.17353781963402 800 6457456
SGTC_1975 st070967 30.8 µM 0.93914796158965 0.183406719015693 no 620 0.173827391238991 935 261391
SGTC_2544 sphondin 68.51 µM 0.938350398902969 0.183609739696168 no 621 0.174032183660371 840 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_504 lovastatin 124 µM 0.937846713264267 0.183738025688265 no 622 0.174161595432908 808 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1530 rhein 70.4 µM 0.93690517743482 0.183977979447027 no 623 0.17440366787623 933 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2288 7946289 167.31 µM 0.933097106632666 0.184950469029611 no 624 0.175384916446199 939 1246052
SGTC_305 1682-2595 20.8 µM 0.933075592220809 0.184955972350705 no 625 0.175390470118743 901 226033
SGTC_1982 st072467 71.9 µM 0.933057497660485 0.184960600962959 no 626 0.175395141086304 914 3163533
SGTC_2817 7995342 71.43 µM 0.931617580125795 0.185329164487966 no 627 0.175767097223158 783 18879975
SGTC_1342 1486-1464 234 µM 0.931521283605358 0.185353828951033 no 628 0.175791990128807 877 3253938
SGTC_2135 5326629 150.42 µM 0.931014216751179 0.185483737785953 no 629 0.175923105090862 820 5020077
SGTC_186 3455-3465 67.277 µM 0.92794030415134 0.186272473072781 no 630 0.176719268072754 824 755278
SGTC_2477 5967686 25.23 µM 0.92662329059253 0.186611040608441 no 631 0.177061078982169 858 776118
SGTC_885 0865-0106 16.8 µM 0.923320777411121 0.187461699112904 no 632 0.177920031631156 877 2793380
SGTC_697 0508-1955 564 µM 0.922599822893129 0.187647720169691 no 633 0.178107894008472 920 6243113
SGTC_1134 3477-0009 42.5 µM 0.921374981393739 0.187964015748721 no 634 0.178427343060306 919 3973534
SGTC_740 k014-0057 261 µM 0.920835437927004 0.188103448523017 no 635 0.178568175020972 955 4012779
SGTC_2961 9083290 32.55 µM 0.920226860667245 0.188260798105934 no 636 0.178727110215564 847 17741490
SGTC_3353 9151644 39.2805 µM 0.919714648559704 0.18839329509255 no 637 0.17886094782327 883 4909158
SGTC_1216 1165-0504 9.65 µM 0.918697345943461 0.188656617386639 no 638 0.17912694921397 910 6304004
SGTC_2195 6536160 144.242 µM 0.916759812612365 0.189158762727294 no 639 0.179634257832643 806 3834386
SGTC_2746 daunorubicin 9.88 µM 0.916758676047828 0.189159057529022 no 640 0.179634555686555 778 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2843 9000894 45.46 µM 0.9144967176527 0.189746324014362 no 641 0.180227950908762 758 2242070
SGTC_2439 5492030 7.2 µM 0.914491948526115 0.189747563393911 no 642 0.180229203325038 884 5722370
SGTC_1309 pyrazolanthrone 13.4 µM 0.913381310233738 0.190036326740058 no 643 0.180521015845917 952 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2395 5646831 180.19 µM 0.90926118452862 0.191109907242291 no 644 0.181606137183695 886 6808628
SGTC_2998 9066762 71.4286 µM 0.905839670475567 0.19200427120372 no 645 0.182510360109386 911 4945196
SGTC_2378 9074213 121.43 µM 0.905752911304891 0.192026982797368 no 646 0.1825333249444 907 657714
SGTC_1663 st014140 55.4 µM 0.905493222287931 0.192094973348173 no 647 0.182602074462238 1053 4207120
SGTC_495 decylubiquinone 155 µM 0.905356897496459 0.192130671155708 no 648 0.182638171269079 842 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1161 k007-0610 110 µM 0.904643914630116 0.192317437906523 no 649 0.18282703126632 994 5843850
SGTC_2218 6965428 192.983 µM 0.904541386235386 0.192344304475833 no 650 0.182854199741953 904 675684
SGTC_2157 5649910 96.377 µM 0.903620639590864 0.192585680031137 no 651 0.183098296606514 892 2858091
SGTC_147 4466-0538 29.23 µM 0.89909669920963 0.193774327324265 no 652 0.184300578057868 955 6742687 YHR072W ERG7
SGTC_1788 fluconazole 20 µM 0.896724913220731 0.194399287749249 no 653 0.184932861669181 851 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2325 6158266 200 µM 0.895879744883139 0.194622283966998 no 654 0.185158496602072 879 3623240
SGTC_2433 5607874 27.82 µM 0.895762463774101 0.194653240680188 no 655 0.185189820691619 913 2252428
SGTC_412 gemfibrozil 100 µM 0.895474578458802 0.194729241605759 no 656 0.185266724652992 884 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_342 k048-0088 23.3 µM 0.893878791860852 0.195150852122287 no 657 0.185693373080221 903 6820570
SGTC_302 1094-0063 18.9 µM 0.893036621037697 0.195373579088773 no 658 0.185918780832794 849 5440289
SGTC_704 1310-0270 142 µM 0.891946177396996 0.195662195499724 no 659 0.18621089096905 950 5718033
SGTC_1124 fisetin 1.16336 µM 0.888508541126451 0.19657375492486 no 660 0.187133631769884 876 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_736 0958-0254 92.6 µM 0.887898490783592 0.196735790629304 no 661 0.187297678315729 950 6812352
SGTC_1671 st016596 74.5 µM 0.88736077091379 0.196878681663401 no 662 0.187442348421812 968 2829167
SGTC_1759 st043059 70 µM 0.886131699892253 0.197205524822524 no 663 0.187773281411335 925 669426
SGTC_951 1171-0579 82.7 µM 0.885797785130441 0.197294378447543 no 664 0.187863251787242 963 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3144 9087057 49.47 µM 0.884116087899476 0.197742240556479 no 665 0.188316774735332 903 17249618
SGTC_369 0957-0393 4.5 µM 0.880394914123263 0.198735428263007 no 666 0.18932270535639 891 6997992
SGTC_2614 arthonioic acid 13.39 µM 0.880093545324686 0.198815995561771 no 667 0.189404317761446 897 6710684
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.880040563122799 0.198830161746646 no 668 0.189418667884258 953 688669
SGTC_1906 st060206 94.7 µM 0.877443427624673 0.199525319944577 no 669 0.190122916922228 987 5133468
SGTC_3292 9120825 59.784 µM 0.877229676897298 0.199582598276089 no 670 0.190180949948334 973 24824900
SGTC_3258 9138477 49.47 µM 0.876174101420627 0.199865603675844 no 671 0.190467696785937 950 4970355
SGTC_2112 5488546 200 µM 0.875538762421931 0.200036057729821 no 672 0.190640414392859 921 600757
SGTC_2114 5491910 81.25 µM 0.875381550798832 0.200078249261865 no 673 0.190683167378786 934 2849228
SGTC_91 0417-1751 58.384 µM 0.872967509550461 0.200726786992093 no 674 0.191340393639331 1092 6795624
SGTC_3043 9092303 49.47 µM 0.872953479269663 0.200730559943713 no 675 0.191344217457188 917 25236084
SGTC_1166 k206-0078 225 µM 0.870891852088699 0.201285424802613 no 676 0.191906603037454 959 5404595
SGTC_2457 5731572 11.68 µM 0.870573519072103 0.201371182598093 no 677 0.191993530309689 980 2865357
SGTC_1478 0453-0656 35.7 µM 0.870287882104086 0.201448150831196 no 678 0.192071549773035 973 5258496
SGTC_266 formosanin C 406 nM 0.868274735546779 0.201991116619034 no 679 0.192621974745461 958 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2107 5363541 170.161 µM 0.866084052366772 0.202582959938218 no 680 0.193222035012393 975 244052
SGTC_2512 diallyl trisulfide 49.23 µM 0.863649136688705 0.203242000913708 no 681 0.193890331351887 938 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.863474602310392 0.203289289966496 no 682 0.193938288777353 949 7104
SGTC_836 0330-0104 1.35 µM 0.863049528072294 0.203404488772461 no 683 0.194055118159686 952 46494820
SGTC_268 camptothecin 39.6153 µM 0.861943149503406 0.203704509517135 no 684 0.194359401374855 1013 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_358 0075-0058 9.45 µM 0.861874502061015 0.203723133585593 no 685 0.194378290793978 1010 1069125
SGTC_408 cantharidin 100 µM 0.861553406845339 0.203810260277013 no 686 0.194466660012057 955 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2821 7996764 71.43 µM 0.860368873135401 0.204131866340182 no 687 0.194792869211549 1002 2987135
SGTC_470 aa-861 153 µM 0.860160379149868 0.204188504633897 no 688 0.194850320880093 952 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1531 st059297 52.4 µM 0.859832838502506 0.204277501366694 no 689 0.194940597322368 968 7566702
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.856863385746688 0.205085390725057 no 690 0.195760195003265 912 15053
SGTC_1140 3229-1848 2.98 µM 0.856468372123198 0.205193003720443 no 691 0.195869379982947 978 2849525
SGTC_575 k072-0246 11.9 µM 0.856316198789682 0.205234469034345 no 692 0.195911451788582 984 6796779
SGTC_857 0438-0306 1.35 µM 0.855788400430492 0.205378326002747 no 693 0.196057416225481 973 4686136
SGTC_2285 7945142 200 µM 0.854542623659847 0.205718112919807 no 694 0.196402201540984 915 2970608
SGTC_2014 4013930 200 µM 0.854381129609518 0.205762185005464 no 695 0.196446924062828 1007 64556
SGTC_1139 k015-0024 46.9 µM 0.853916394735053 0.205889043443915 no 696 0.196575657448893 995 2766652
SGTC_1208 2323-2347 50.3 µM 0.853721872109651 0.20594215595624 no 697 0.196629556150695 987 5412760
SGTC_1550 gossypolone 36.6 µM 0.852643421569337 0.206236763792299 no 698 0.196928537664355 1012 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1482 3346-2049 8.48 µM 0.851911614014049 0.206436818951766 no 699 0.197131575136491 964 3826804
SGTC_1162 k048-0130 20.1 µM 0.851383594163834 0.206581235790094 no 700 0.197278151056704 949 6797406
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.851251120556065 0.206617477564647 no 701 0.197314935472955 959 364106
SGTC_1120 ficusin 1.78878 µM 0.851168379943319 0.206640115430007 no 702 0.197337912456833 967 6199 A DNA cross-linker.
SGTC_1026 k007-1105 30.6 µM 0.849739442938049 0.207031304857322 no 703 0.197734982068427 976 7066794
SGTC_308 4092-1169 104 µM 0.848297562595788 0.207426481483387 no 704 0.198136137341736 998 2268590 YDL196W YDL196W
SGTC_1946 st076057 65.1 µM 0.845182858523954 0.208281649894939 no 705 0.199004375702373 872 953009
SGTC_684 1140-0066 328 µM 0.844214030829083 0.208548073273461 no 706 0.199274907732738 1020 6813534
SGTC_1509 1326-1131 80 µM 0.843960468679132 0.208617834917169 no 707 0.199345748084882 951 768313
SGTC_2346 9031566 143.75 µM 0.843897356102892 0.208635200991553 no 708 0.199363382872463 978 4771086
SGTC_927 2425-1185 123 µM 0.841979217198406 0.209163403036989 no 709 0.199899793315098 970 730375
SGTC_883 0850-0245 24.6 µM 0.840993616335007 0.209435115999007 no 710 0.20017575532997 1003 6823229 YPR165W RHO1
SGTC_3023 9089636 49.47 µM 0.838120508894564 0.21022836575246 no 711 0.200981512798322 1068 17249241
SGTC_296 1222-0039 74.9 µM 0.83637479631103 0.210711208320113 no 712 0.201472043427341 958 5984176
SGTC_3024 9090631 49.47 µM 0.836361843540525 0.210714793326327 no 713 0.201475685726747 966 25236383
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.836070947919351 0.210795315457523 no 714 0.20155749552735 987 279621
SGTC_1039 k821-0043 94 µM 0.835341830046207 0.210997220146787 no 715 0.20176263585833 1014 15992768
SGTC_1422 4031-0024 15.5 µM 0.834139269696694 0.211330476398406 no 716 0.20210125423582 979 782427
SGTC_211 3455-0679 143.504 µM 0.829380048600483 0.212652383699396 no 717 0.203444693754408 1019 748649
SGTC_20 0481-0013 4.944 µM 0.828408874022448 0.212922726286451 no 718 0.203719491315373 1027 182045
SGTC_3330 9141424 71.43 µM 0.827365590025495 0.21321336506537 no 719 0.20401493892423 1031 27261020
SGTC_35 0133-0054 64.071 µM 0.82694007352328 0.213331972140434 no 720 0.204135514204601 962 99677
SGTC_3289 9119912 71.43 µM 0.826748257042518 0.213385451013523 no 721 0.204189881615774 994 17014829
SGTC_2504 purpurogallin 52.29 µM 0.826580336431934 0.213432274078094 no 722 0.204237483190746 953 5281571 An antioxidant.
SGTC_46 0329-0187a 2.197 µM 0.825393652488011 0.213763340265944 no 723 0.204574068718417 1036 46494817
SGTC_372 0155-0182 15.9 µM 0.824482307975569 0.214017793999794 no 724 0.204832782177954 1050 771486
SGTC_3301 9125354 19.7965 µM 0.824287869871237 0.214072105283351 no 725 0.204888004649387 932 41905162
SGTC_3108 9121785 49.47 µM 0.823896640333183 0.214181409496439 no 726 0.204999144784536 1018 17140271
SGTC_2912 7964298 10.93 µM 0.823096475686813 0.214405065715151 no 727 0.205226566411491 1015 2975850
SGTC_89 0302-0250 142.109 µM 0.822984637275058 0.214436336791362 no 728 0.205258364897064 1119 4203518 YLR208W SEC13
SGTC_1103 duloxetine 36.1 µM 0.819730855666535 0.215347285232589 no 729 0.206184777971767 1106 60835 A selective serotonin reuptake inhibitor.
SGTC_1467 k284-1082 293 µM 0.817717240362341 0.215912152138517 no 730 0.206759331876537 1023 3334705
SGTC_1381 2324-0066 62.1 µM 0.817494553088337 0.215974673886601 no 731 0.206822930396143 955 10885928
SGTC_1306 1185-0270 9.02 µM 0.816470225845523 0.21626239937582 no 732 0.207115622924725 1045 1548076
SGTC_354 2783-3500 4.88 µM 0.815959629215706 0.216405904805929 no 733 0.207261612900979 976 6740761
SGTC_1082 camptothecin 424.86 nM 0.815414921057299 0.216559058172274 no 734 0.207417423125828 1012 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1811 st050069 61.5 µM 0.813859628556403 0.216996698386941 no 735 0.207862685359847 1041 3877702
SGTC_2700 st077718 96.8 µM 0.812906566052458 0.217265130859035 no 736 0.20813581482402 959 904970
SGTC_1312 1218-2183 165 µM 0.812155804755729 0.217476719658309 no 737 0.20835111769718 1058 6744073
SGTC_1790 st045711 43.5 µM 0.811512777292804 0.217658040115972 no 738 0.208535629131615 1028 585119
SGTC_895 0964-0006 13.7 µM 0.811401304368713 0.217689482046513 no 739 0.208567625164738 1023 6738897
SGTC_2019 4016004 108 µM 0.811243515323924 0.217733992330896 no 740 0.208612920244924 995 45595336
SGTC_1914 st062367 72.6 µM 0.809837894231825 0.218130731823086 no 741 0.20901667508571 971 978205
SGTC_1641 st009299 47.1 µM 0.809097310338576 0.218339930656163 no 742 0.209229587627473 986 4046054
SGTC_810 3825-7150 143 µM 0.80901958992474 0.218361891680752 no 743 0.209251939087132 1076 22330411 YGL099W LSG1
SGTC_2966 9084041 48.03 µM 0.808178209145272 0.218599717396114 no 744 0.209494000070985 995 17741380
SGTC_483 fpl-64176 144 µM 0.807368057030688 0.218828856835852 no 745 0.209727232327426 1007 3423
SGTC_2835 9006588 71.43 µM 0.807022111069485 0.218926744580774 no 746 0.209826872168418 961 2345538
SGTC_1795 st049545 62.3 µM 0.806409676515303 0.219100098824397 no 747 0.210003334649337 1032 5291882
SGTC_1408 3909-7976 48.8 µM 0.805887561542118 0.219247949733429 no 748 0.210153841933627 1064 24152374
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.804564214602364 0.219622947817225 no 749 0.210535599759017 1001 5377381
SGTC_1352 1496-0991 99 µM 0.803796455216866 0.219840677254742 no 750 0.210757268661098 1061 3000039
SGTC_789 1309-1135 70.6 µM 0.803667238617599 0.219877334059876 no 751 0.210794589769896 1079 3092424
SGTC_2879 9041815 71.43 µM 0.802975184666413 0.220073719048879 no 752 0.210994538881441 975 4942971
SGTC_2681 menadione 3.18 µM 0.800982580865421 0.220639724233878 no 753 0.211570865098087 1044 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3132 9126706 49.47 µM 0.799223341014123 0.221140134070795 no 754 0.212080460019513 993 850858
SGTC_1323 1348-1351 11.2 µM 0.79875137218671 0.221274494399557 no 755 0.212217296139486 989 6989654
SGTC_2370 9071495 200 µM 0.798499167086636 0.221346311414804 no 756 0.212290438153652 962 21791103
SGTC_2369 9071472 200 µM 0.797091600018744 0.221747369847628 no 757 0.212698917236832 1033 17296037
SGTC_70 0141-0289 43.283 µM 0.796512250994162 0.221912564435294 no 758 0.212867178836508 1136 352408
SGTC_671 0560-0003 407 µM 0.795702543813247 0.222143560659779 no 759 0.213102473976253 1010 3238678
SGTC_1734 st037168 69.4 µM 0.794860363272735 0.222383966539769 no 760 0.213347366533052 978 708907
SGTC_566 0958-0068 16.5 µM 0.79371101042414 0.222712296081756 no 761 0.213681844461246 1008 6815365
SGTC_1755 st041960 45.185 µM 0.793027554769443 0.222907666157838 no 762 0.213880884464245 1034 2257073
SGTC_404 fumagillin 50 µM 0.792456854976848 0.223070879038899 no 763 0.214047169712091 1048 12015870 A methionine aminopeptidase binder.
SGTC_1261 0712-0010 12.7 µM 0.79217013867781 0.223152901928613 no 764 0.214130738855056 1074 2840123
SGTC_2728 chlorpromazine 9.18 µM 0.79164575994119 0.22330295894523 no 765 0.214283628527399 1013 2726 A thorazine and dopamine antagonist.
SGTC_699 0375-0592 111 µM 0.790337128682386 0.223677689228683 no 766 0.214665454424117 1103 762578
SGTC_2813 7971799 71.43 µM 0.789888777359541 0.223806158094603 no 767 0.214796363021824 1016 2234054
SGTC_2293 7624732 200 µM 0.788039716518379 0.224336423821238 no 768 0.215336737435138 1056 894453
SGTC_2469 5655019 90.81 µM 0.787655085421166 0.224446816213852 no 769 0.215449242066305 1114 2788239
SGTC_2111 5486399 200 µM 0.786740902458097 0.224709318164373 no 770 0.215716777452533 1100 689674
SGTC_2161 5662504 8.5105 µM 0.785067071274277 0.225190399339302 no 771 0.216207122481397 1006 2859334
SGTC_2186 6124449 200 µM 0.783583529039857 0.225617276226889 no 772 0.216642261799816 1039 3834182 YLR033W RSC58
SGTC_1879 gemcitabine 100 µM 0.782257390875645 0.225999248694314 no 773 0.217031661209386 1059 60750 A nucleoside analog which inhibits DNA replication.
SGTC_322 k048-0136 19.3 µM 0.782214331093293 0.226011657487141 no 774 0.217044311806706 1042 6823282
SGTC_2105 5350118 200 µM 0.78144298852725 0.226234005082483 no 775 0.217270997856429 1079 2133313
SGTC_1212 0520-0165 585 µM 0.780400982399596 0.226534570442729 no 776 0.217577444904865 1059 5403258
SGTC_1461 k072-0203 53.8 µM 0.77856597187669 0.227064424603287 no 777 0.218117715254204 1039 5418714
SGTC_80 0159-0065 512.242 µM 0.775794566328982 0.22786598317394 no 778 0.218935146374872 1018 1548079
SGTC_2329 6138490 200 µM 0.774128589133119 0.228348589892346 no 779 0.219427376249288 946 720019
SGTC_319 1348-1596 45.5 µM 0.773140267922233 0.228635161853614 no 780 0.219719686018404 1093 5380505
SGTC_919 tnp00227 403.569 nM 0.771395944420633 0.229141435425197 no 781 0.220236139119475 1079 1269246 A methoxyflavone. YNL221C POP1
SGTC_907 3448-6986 75.5 µM 0.770736164048365 0.229333094269387 no 782 0.220431665838403 1109 590582
SGTC_3006 9075424 71.4286 µM 0.768368797016256 0.23002152721485 no 783 0.221134056341137 1065 7465181
SGTC_615 k087-0205 167 µM 0.768083021601327 0.23010470917876 no 784 0.221218931561432 1069 9642773
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.767363470263719 0.230314226814154 no 785 0.221432720624503 1131 4174840
SGTC_3322 9139058 2.11 µM 0.765681326299196 0.230804446359895 no 786 0.221932970414055 1071 4908926 YPR165W RHO1
SGTC_1692 fluoroquinolonic acid 71 µM 0.765071775703444 0.230982228650602 no 787 0.222114402751063 1080 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2587 piperic acid 92.2 µM 0.76478500453337 0.231065895124982 no 788 0.222199789278098 1032 5370536
SGTC_2233 sulbentine 40.3845 µM 0.763962638838502 0.231305916918099 no 789 0.222444753695728 1108 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.760603345633768 0.232287828254675 no 790 0.223447010424118 1128 94937 An inhibitor of serotonin biosynthesis.
SGTC_1247 0448-0043 5.84 µM 0.757865498872347 0.233089804951103 no 791 0.224265753162272 1118 3089013 YGL099W LSG1
SGTC_1469 k284-2957 126 µM 0.757491979277662 0.233199336265787 no 792 0.224377584675677 1121 23884841
SGTC_1738 st035555 74 µM 0.757199955328421 0.233284989599668 no 793 0.224465038490642 1103 5331140
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.756476024151984 0.23349740059942 no 794 0.224681921030021 1162 91467 include heat shock
SGTC_3051 9093778 49.47 µM 0.756335756364847 0.233538569429341 no 795 0.224723957597423 1086 17217378
SGTC_1512 0259-0544 12.2 µM 0.756007345077168 0.233634974435436 no 796 0.22482239595162 1125 18476
SGTC_3122 9126309 49.47 µM 0.755451828757293 0.23379809625287 no 797 0.224988962654047 1179 17591206
SGTC_2381 9035592 200 µM 0.751482200921672 0.234965573004511 no 798 0.226181254359288 1038 4749657
SGTC_1962 st076595 64.5 µM 0.749795359606707 0.235462650487562 no 799 0.226688981988334 1132 279619
SGTC_1911 st060208 74.3 µM 0.749440132549808 0.235567402523395 no 800 0.22679598481631 1115 688783
SGTC_2866 9034245 58.44 µM 0.74679361016544 0.236348637741623 no 801 0.227594076642348 1122 6462273
SGTC_2425 5628681 7.85 µM 0.744857955439078 0.236920931675339 no 802 0.228178797318467 1154 5714958
SGTC_561 1550-0330 72.9 µM 0.744378761006509 0.237062727418014 no 803 0.228323682219523 1090 6812934
SGTC_3347 9188721 44.724 µM 0.7429715064099 0.237479409695422 no 804 0.228749465748162 1074 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_939 1165-0479 45.3 µM 0.742749213254843 0.237545266530181 no 805 0.228816764234007 1098 1377347
SGTC_2741 miltefosine 3.04 µM 0.741159713014959 0.238016465718927 no 806 0.229298303673757 1017 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1524 corynanthine 62.1 µM 0.740611924656579 0.23817897339739 no 807 0.229464387820481 1108 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2130 NSC 7 2.4545 µM 0.740046502390831 0.23834677611621 no 808 0.229635889080492 1134 21448
SGTC_2916 7875993 68.79 µM 0.739558418961558 0.238491678718982 no 809 0.229783990006636 1103 1299250
SGTC_1024 4507-0395 26 µM 0.739118391215559 0.238622355839757 no 810 0.229917555054425 1122 4201836
SGTC_1632 st005650 90 µM 0.733353255310844 0.240338070267361 no 811 0.231671500808352 1115 2759605
SGTC_100 0086-0128 49.5915 µM 0.733349931828014 0.240339061276078 no 812 0.231672514067956 1131 93297
SGTC_2008 4012253 172 µM 0.733064012551576 0.240424326103821 no 813 0.231759694051143 1149 603940
SGTC_2941 9056145 11.23 µM 0.731855075692108 0.240785028758294 no 814 0.232128514364775 1062 2119517
SGTC_2080 5212524 12.4 µM 0.729851301297734 0.241383529880422 no 815 0.232740541166672 1110 260183
SGTC_1454 4239-0054 42.6 µM 0.728443561634986 0.24180448611248 no 816 0.233171052677042 1188 1340767
SGTC_2647 atorvastatin 60.16 µM 0.728140141525106 0.241895269951184 no 817 0.233263901749764 1105 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1202 1988-0068 29.6 µM 0.727994537069032 0.241938841629533 no 818 0.233308465207116 1112 2850480
SGTC_2664 lyso-paf C-16 73.48 µM 0.726962170590066 0.242247896142817 no 819 0.233624565032408 1162 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1594 piperine 70.1 µM 0.726231174582511 0.242466860182042 no 820 0.233848531891873 1137 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_325 2810-4341 181 µM 0.725428128555491 0.24270752976051 no 821 0.234094710948509 1161 774970
SGTC_1634 st006576 41 µM 0.725350183943974 0.242730896321851 no 822 0.23411861302215 1136 3915356
SGTC_3331 9141060 1.957 µM 0.723250230452197 0.243360887264395 no 823 0.234763081854037 1153 4906567 YPR165W RHO1
SGTC_253 dyclonine 31.25 µM 0.723123233531507 0.243399014949887 no 824 0.234802088216833 1208 3180 An oral anasthetic.
SGTC_64 000l-0018 272.079 µM 0.722947055953915 0.243451913255836 no 825 0.23485620606304 1123 6811119
SGTC_1909 st060837 51.5 µM 0.719826240776546 0.244389984177422 no 826 0.235815993121182 1107 678937
SGTC_1497 4476-2978 41.3 µM 0.719688958892553 0.244431293762206 no 827 0.235858262897572 1204 1528379
SGTC_1017 4239-0030 168 µM 0.719304508482637 0.24454699901447 no 828 0.235976659318892 1157 1149593
SGTC_2151 5563267 85.4165 µM 0.719257351359835 0.244561193582865 no 829 0.235991184212866 1144 5310824
SGTC_1136 pergolide 1.05886 µM 0.716080649834513 0.24551842031866 no 830 0.236970775613839 1123 47811 A dopamine receptor agonist.
SGTC_1280 0880-0253 10.1 µM 0.715838782067192 0.245591384037925 no 831 0.237045451219072 1146 6836607
SGTC_1899 st063254 59.6 µM 0.714074080586098 0.246124089974787 no 832 0.23759068620935 1120 3093813
SGTC_2999 9069765 71.4286 µM 0.713506851846638 0.246295449390028 no 833 0.237766087368465 1171 2097066
SGTC_3205 9113483 49.47 µM 0.710456648485499 0.247218009408745 no 834 0.238710502485895 1171 17018033
SGTC_1374 2889-5571 141 µM 0.70941401589375 0.247533785782712 no 835 0.239033796279748 1169 2853281
SGTC_2847 9005661 71.43 µM 0.709196656084432 0.24759964348239 no 836 0.23910122415581 1079 2991449
SGTC_458 nppb 133 µM 0.70888035384368 0.2476954963993 no 837 0.239199363846458 1180 4549 A chloride channel blocker.
SGTC_2402 5553605 200 µM 0.708116484823768 0.247927062615375 no 838 0.239436461663033 1203 6758546
SGTC_2324 6149169 200 µM 0.707866861547064 0.248002760730005 no 839 0.239513970212736 1117 2888231
SGTC_1409 3909-8004 61.9 µM 0.707670837383592 0.248062213588007 no 840 0.239574845726956 1184 2119279
SGTC_2967 9089538 49.85 µM 0.707472115136711 0.248122492517622 no 841 0.239636567754302 1195 728216
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.707152030887303 0.248219600920438 no 842 0.239736002392014 1144 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1346 1488-2224 62.4 µM 0.706197892724477 0.248509191271097 no 843 0.240032540335849 1179 3722427
SGTC_2877 9040724 71.43 µM 0.705462533340252 0.248732502879729 no 844 0.240261220107653 1154 6463895
SGTC_3352 9151559 45.5865 µM 0.7046845180026 0.248968884397725 no 845 0.240503294080895 1161 17159339
SGTC_1207 2099-0101 141 µM 0.704272813787126 0.249094019315313 no 846 0.240631446654556 1211 5837381
SGTC_1389 3405-0187 19 µM 0.703704308666425 0.249266867869514 no 847 0.240808468267717 1131 799890
SGTC_111 0083-0039 52.457 µM 0.703679681011859 0.249274357113686 no 848 0.240816138448888 1106 759313
SGTC_3071 9117417 49.47 µM 0.702450455889243 0.249648315161728 no 849 0.241199144373473 1109 45595590 YGL055W OLE1
SGTC_871 0574-0004 149 µM 0.702430235020388 0.249654469297023 no 850 0.241205447623831 1142 9551173
SGTC_2447 5741742 33.78 µM 0.701133470223227 0.250049302360456 no 851 0.241609862135532 1207 1776504
SGTC_262 fenpropimorph 62.5 µM 0.699281268232955 0.25061382645925 no 852 0.242188135490448 1143 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3222 9128301 49.47 µM 0.697911451914094 0.251031760331215 no 853 0.242616286057384 1220 4911358
SGTC_1922 5578187 25 µM 0.696440341540042 0.251481009580099 no 854 0.243076553195564 1196 1350412
SGTC_1079 idarubicin 2.36 µM 0.694195973791397 0.252167214648535 no 855 0.243779658604577 1174 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2455 5377712 9.75 µM 0.69155653277181 0.252975473387937 no 856 0.244607933421165 1169 2243908
SGTC_2231 micatex 6.853 µM 0.689398140799136 0.253637435429706 no 857 0.245286376548954 1201 20737 An antifungal of unknown mechanism.
SGTC_1762 st045503 25.4615 µM 0.687324882698468 0.254274143195159 no 858 0.245939011015972 1235 4645554
SGTC_1001 4048-4355 44.4 µM 0.68655538584085 0.254510672514411 no 859 0.24618147542903 1207 21824233
SGTC_2170 morpholine 200 µM 0.686111148525119 0.254647275440707 no 860 0.246321510612307 1213 121171 Reacts with secondary amines.
SGTC_3097 9117246 49.47 µM 0.685723298925858 0.254766570539787 no 861 0.246443805822593 1239 16423892
SGTC_1169 aniline yellow 25.8 µM 0.684628651161105 0.255103420958524 no 862 0.246789141283961 1176 6051 A DNA damaging agent.
SGTC_635 k038-0028 24.7 µM 0.684525443969752 0.2551351923983 no 863 0.246821714069288 1233 4035102
SGTC_1005 4092-0690 4.4 µM 0.684521252229252 0.255136482833031 no 864 0.246823037055418 1199 1529343
SGTC_1183 1254-0324 198 µM 0.684495019776649 0.255144558617508 no 865 0.24683131655944 1233 5799357
SGTC_1293 1000-1278 195 µM 0.681615189997954 0.256031940087665 no 866 0.247741153694534 1262 678847
SGTC_1884 5633444 25 µM 0.681531635907154 0.256057710187747 no 867 0.247767578007292 1226 5724239
SGTC_1242 0402-0103 60.1 µM 0.680951469548624 0.256236684814237 no 868 0.247951099414306 1188 432868
SGTC_686 1319-0111 510 µM 0.679485247935774 0.256689287778174 no 869 0.248415225824221 1268 4562600
SGTC_2747 doxorubicin 7.63 µM 0.677622693366913 0.2572648330708 no 870 0.249005476836995 1115 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1291 0993-0025 5.79 µM 0.676777476629779 0.257526233367324 no 871 0.249273575366737 1236 4353356
SGTC_2740 felodipine 17.08 µM 0.674348242838134 0.258278290157357 no 872 0.250044969869115 1180 3333 L-type calcium channel blocker
SGTC_442 cape 100 µM 0.674197398987004 0.258325026809524 no 873 0.25009291152413 1206 5281787
SGTC_1807 st050092 58.9 µM 0.674029133854316 0.258377166348998 no 874 0.250146395817254 1194 5008496
SGTC_2476 5806916 10.51 µM 0.671722485295033 0.259092466200334 no 875 0.250880192013165 1159 2870194
SGTC_131 0141-0277 33.849 µM 0.670729762960587 0.259400627749449 no 876 0.251196349413344 1198 1547771
SGTC_2456 5770359 74.46 µM 0.670360660042196 0.259515253198905 no 877 0.251313953235953 1244 3118787
SGTC_1470 k295-0292 231 µM 0.670169620381277 0.25957459111524 no 878 0.251374833852585 1270 5045612
SGTC_427 1354-0053 47.3 µM 0.668528896938231 0.260084496670254 no 879 0.251898021263009 1291 6813657
SGTC_1476 4112-3294 3.34 µM 0.668455163303363 0.260107423796843 no 880 0.251921546640695 1271 704369
SGTC_51 1013-0126 23.419 µM 0.665991285740603 0.260874153600936 no 881 0.252708335198545 1340 1627850
SGTC_2361 9034121 116 µM 0.663699720639533 0.26158830376085 no 882 0.253441259105819 1238 6496917
SGTC_525 k781-2675 26.7 µM 0.663352921406226 0.261696468660909 no 883 0.253552275058494 1284 3651118 YDL195W SEC31
SGTC_1070 indatraline 8.81 µM 0.663246419228377 0.261729690748753 no 884 0.253586373227038 1233 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_953 1188-0045 9.7 µM 0.661828476753897 0.262172207131023 no 885 0.254040576857622 1230 6144426
SGTC_1086 cerivastatin 2.18 µM 0.661581727250674 0.26224925271016 no 886 0.254119660678155 1217 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3045 9092950 49.47 µM 0.660269257983075 0.262659255684717 no 887 0.254540527207932 1286 44120432
SGTC_3135 9127742 49.47 µM 0.658535388473435 0.263201402491036 no 888 0.255097082534515 1247 3643468
SGTC_2202 7226349 200 µM 0.657948648903463 0.263384993749432 no 889 0.255285564294787 1210 844334
SGTC_1782 st039423 80.636 µM 0.656126675561582 0.263955507034669 no 890 0.25587131108048 1224 2068169
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.655743305285959 0.264075631669539 no 891 0.25599465017235 1128 88881 An O-methylated flavonoid and antioxidant.
SGTC_1510 1123-0200 71.5 µM 0.654151484581 0.264574708001135 no 892 0.256507107322979 1341 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_998 3996-0085 177 µM 0.653268261308674 0.264851827827561 no 893 0.256791675019501 1281 715391
SGTC_1339 1486-1321 22.7 µM 0.653182377206602 0.264878782662488 no 894 0.256819354975602 1271 3469382
SGTC_1854 st056233 32.9 µM 0.65248779968357 0.265096827928689 no 895 0.257043270399597 1225 5393174
SGTC_2670 beta-carotene 100 µM 0.652432873499052 0.265114074521656 no 896 0.25706098163852 1201 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_631 k072-0230 41.5 µM 0.652255928717213 0.265169638320407 no 897 0.257118042735698 1279 5773147
SGTC_2255 7941087 197.44 µM 0.652005225095123 0.265248373826875 no 898 0.257198900836269 1294 935561
SGTC_1084 voriconazole 435 nM 0.649842739212235 0.265928012449839 no 899 0.257896904289361 1272 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_72 0744-0168 198.391 µM 0.649702958662797 0.265971973833112 no 900 0.25794205620817 1212 677577
SGTC_717 1532-0246 73.2 µM 0.648610505861254 0.266315680150419 no 901 0.258295081580377 1254 9561992
SGTC_1737 st035557 69.7 µM 0.64754705743881 0.266650476912636 no 902 0.258638974566244 1219 5716916
SGTC_3055 9094636 49.47 µM 0.646989438559812 0.266826112499833 no 903 0.25881938944547 1308 25236176
SGTC_568 1193-0097 7.48 µM 0.643942849867779 0.267786740498202 no 904 0.2598062470436 1189 3646150
SGTC_2488 5268135 45.7 µM 0.643727791976759 0.267854616757259 no 905 0.259875982351416 1293 1270356 YLR208W SEC13
SGTC_446 go6976 132 µM 0.642352808430989 0.26828879179718 no 906 0.26032206669712 1251 3501 A protein kinase C inhibitor.
SGTC_1835 st008666 49.2 µM 0.640308850062714 0.268934860946217 no 907 0.260985914115446 1233 690455
SGTC_2475 5812728 15.03 µM 0.637449881094807 0.269839853012767 no 908 0.26191592303911 1280 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2540 epiandrosterone 100 µM 0.637240937344164 0.269906052831451 no 909 0.261983958017461 1354 441302 A steroid.
SGTC_371 0195-0006 7.36 µM 0.63648513790001 0.270145581252315 no 910 0.262230132421385 1210 3928593
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.636443664500684 0.270158728103974 no 911 0.262243644314125 1328 65057 A dermal irritant. YDR527W RBA50
SGTC_1275 0867-0008 21.1 µM 0.636049972889516 0.270283542229632 no 912 0.262371925464933 1285 3422836
SGTC_2840 9008771 71.43 µM 0.635860590814497 0.270343593295115 no 913 0.262433645490458 1269 2992978
SGTC_2093 5331342 194.4 µM 0.635430487123337 0.270479999423739 no 914 0.262573844815235 1284 33839
SGTC_2238 6671620 73.2395 µM 0.634293284248862 0.270840825584871 no 915 0.262944719242797 1255 729941
SGTC_1148 3909-7663 27.7 µM 0.633791817759853 0.271000013530752 no 916 0.263108346867643 1351 4084526
SGTC_2323 6148992 148.28 µM 0.633671399451663 0.271038246649249 no 917 0.26314764689336 1247 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2891 9063876 19.48 µM 0.632991684286547 0.271254108383255 no 918 0.26336953669506 1262 6472478
SGTC_2567 aureobasidin a 60 nM 0.632300540772181 0.271473687329956 no 919 0.263595255138262 1363 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.631371144873053 0.271769099493174 no 920 0.263898939228212 1273 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1357 1503-1303 39.5 µM 0.627541109625207 0.272988176917304 no 921 0.265152298790572 1291 292895
SGTC_411 enrofloxacin 100 µM 0.627321331429656 0.27305821317381 no 922 0.26522431169514 1399 71188 A bacterial gyrase inhibitor.
SGTC_346 4513-0042 7.16 µM 0.627048806919112 0.273145070355161 no 923 0.265313621338145 1309 2827372
SGTC_1494 4358-1428 177 µM 0.627034070895413 0.273149767311786 no 924 0.265318450949847 1361 1564571
SGTC_1830 st055982 50.3 µM 0.626698889570121 0.273256613733533 no 925 0.265428315948474 1271 455313 An antimicrobial agent.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.624843368019661 0.273848476332404 no 926 0.266036932066872 1275 77254
SGTC_2764 methyldopa 94.69 µM 0.621632880882614 0.274874032161056 no 927 0.267091647507452 1347 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2415 st077333 57.7 µM 0.621322669309033 0.274973226129959 no 928 0.267193670551721 1392 2766255
SGTC_163 TUB2.036 7.546 µM 0.621081068792954 0.275050493083557 no 929 0.26727314226785 1318 15992207 YJR013W GPI14
SGTC_1428 4049-0204 61.7 µM 0.620300807931274 0.275300103564604 no 930 0.267529881557422 1367 X1428
SGTC_2053 5265679 138 µM 0.619824900695606 0.275452404078073 no 931 0.267686536480088 1284 764595
SGTC_2828 7998861 71.43 µM 0.619344058261203 0.275606326044866 no 932 0.267844862865769 1257 2988188
SGTC_3165 9101544 49.47 µM 0.618838554590876 0.27576818788193 no 933 0.268011360272915 1322 5002184
SGTC_2090 5301565 104.445 µM 0.617345373892155 0.276246575681336 no 934 0.268503472302065 1334 2056344
SGTC_1072 oxiconazole 14.9 nM 0.616844461671349 0.276407149970165 no 935 0.26866866113628 1323 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2625 euphol 100 µM 0.616358631133095 0.276562933336625 no 936 0.268828925160012 1328 6708538 A triterpene alcohol.
SGTC_646 4092-0839 27.3 µM 0.616101436628179 0.27664542112985 no 937 0.268913786986651 1380 877796
SGTC_2767 sibutramine 71.45 µM 0.615017563945892 0.276993174756793 no 938 0.269271560596103 1396 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1317 1273-0028 910 nM 0.614223549975692 0.277248064798276 no 939 0.269533806674041 1305 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1579 chlormadinone acetate 49.4 µM 0.613873065867815 0.277360611784151 no 940 0.26964960489078 1324 45114258 A steroidal progestin.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.612083254033552 0.277935701831622 no 941 0.270241338201047 1369 688788
SGTC_1600 coumarin 106 71.1 µM 0.611987974232946 0.277966332790176 no 942 0.270272857042312 1369 100336 A hepatotoxic, DNA x-linker.
SGTC_66 0109-0187 42.4 µM 0.611245224803782 0.278205171520006 no 943 0.270518623755545 1321 759417
SGTC_2443 5493264 126.67 µM 0.611223554161114 0.278212141440543 no 944 0.270525795982498 1350 5340055
SGTC_2581 avocatin a 64 µM 0.611023203079208 0.278276584314897 no 945 0.270592109702299 1328 6710728 A skin care supplement.
SGTC_326 k292-0812 17.5 µM 0.610437204275272 0.278465112439802 no 946 0.270786114621509 1313 3579357
SGTC_2899 9053889 58.44 µM 0.609403044181094 0.278797975207171 no 947 0.271128660305555 1309 6470052
SGTC_1358 1509-0022 2.48 µM 0.608678191380345 0.27903139731198 no 948 0.271368882622881 1339 3258434
SGTC_1406 3909-7906 11.9 µM 0.607018085146266 0.279566354018808 no 949 0.271919455092371 1333 X1406
SGTC_2563 tomatine 8.54 µM 0.604704256535223 0.280312797451568 no 950 0.272687759704854 1362 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2327 6189656 200 µM 0.603412771841263 0.280729851019341 no 951 0.273117063939595 1405 5349088
SGTC_841 0251-0215 91.2 µM 0.603002944404533 0.280862257519311 no 952 0.273253365227454 1365 3888614
SGTC_500 h-89 112 µM 0.601282355624338 0.281418472246194 no 953 0.273825969771236 1423 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3320 9137005 35.139 µM 0.600937987316792 0.28152985999407 no 954 0.273940645281556 1327 4908713
SGTC_2515 chrysin 20.77 µM 0.600446034395654 0.281689021647255 no 955 0.274104508007038 1375 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1394 3474-0001 65.7 µM 0.599692840398369 0.281932786714907 no 956 0.274355480316946 1291 5017666 YIL048W NEO1
SGTC_1196 1588-0294 184 µM 0.598643005258684 0.282272726702579 no 957 0.274705485778389 1321 6144269
SGTC_733 4069-0007 56.1 µM 0.598184954505054 0.282421106782983 no 958 0.27485826468314 1381 5717425 YNL287W SEC21
SGTC_1587 estradiol valerate 56.1 µM 0.597827716107944 0.282536855934553 no 959 0.274977447550342 1334 13791 A steroid.
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.597120190871759 0.282766169152739 no 960 0.275213569212364 1323 2346 DNA damaging agent; causes G2/M arrest.
SGTC_180 1486-1293 102.781 µM 0.59696421185788 0.282816734922877 no 961 0.275265637352231 1431 4140536
SGTC_132 0417-1715 25.805 µM 0.595554243571062 0.283274019879183 no 962 0.275736525869165 1399 6769098
SGTC_656 4090-1979 187 µM 0.595138819432645 0.283408819027855 no 963 0.275875340955658 1367 22330961
SGTC_922 1866-0035 480 µM 0.593871613699012 0.283820198896975 no 964 0.276298993116416 1388 3156169
SGTC_2373 9071805 200 µM 0.592749421678273 0.284184740685625 no 965 0.276674430596857 1383 10149009
SGTC_2811 7967822 32.47 µM 0.592437255332826 0.284286187073751 no 966 0.276778912537113 1408 2232244
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.590076429514077 0.28505395736861 no 967 0.277569705149183 1380 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1037 k284-1091 78.7 µM 0.590015342365453 0.285073836792937 no 968 0.277590181813331 1324 3334711
SGTC_1239 0337-0584 35.4 µM 0.589976825237975 0.285086371656527 no 969 0.2776030932927 1426 914301 YML130C ERO1
SGTC_3278 9139605 49.47 µM 0.589371110669167 0.285283527588512 no 970 0.277806175859453 1385 7958859
SGTC_11 0438-0307 1.3 µM 0.588544869866338 0.285552567983518 no 971 0.278083312854518 1400 4011476
SGTC_3060 1327-0027 12.5 µM 0.587975786956566 0.28573794287453 no 972 0.278274272568811 1292 16000455 YPR107C YTH1
SGTC_1672 st016598 6.51 µM 0.585723963193989 0.286472020012651 no 973 0.279030513992238 1321 4665860 YNL267W PIK1
SGTC_1691 st019933 84.6 µM 0.585662707215395 0.286492001484354 no 974 0.279051099855269 1354 6176082
SGTC_2283 7944793 200 µM 0.584841455492203 0.286759954575209 no 975 0.279327163411942 1309 2970533
SGTC_1705 st027868 56.3335 µM 0.583296968967706 0.287264201939093 no 976 0.279846701313925 1365 292948
SGTC_2973 9094665 17.96 µM 0.582546699672628 0.287509302844767 no 977 0.280099247644936 1466 25237061 YIL048W NEO1
SGTC_1377 2944-0135 198 µM 0.581178468365482 0.287956536413478 no 978 0.280560088860979 1431 1894137
SGTC_1061 3448-9325 110 µM 0.580707571896625 0.288110534211379 no 979 0.280718778814847 1329 723482
SGTC_549 1661-1316 519 µM 0.578622613435305 0.288792847038093 no 980 0.281421921437289 1423 2857282
SGTC_271 rotenone 740 µM 0.578519156770472 0.288826723537082 no 981 0.281456833840527 1404 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3171 9103192 49.47 µM 0.578236992109217 0.288919126809668 no 982 0.281552063521848 1416 13018434
SGTC_2060 5238662 140 µM 0.578083583501375 0.288969370891734 no 983 0.281603844963096 1355 790130
SGTC_1575 cyproterone acetate 48 µM 0.577642807527332 0.289113755831884 no 984 0.281752649747635 1314 9880 An androgen receptor antagonist and liver toxin.
SGTC_1635 st007035 42.4 µM 0.577546423586263 0.289145332829235 no 985 0.281785193756683 1415 3716403
SGTC_3283 9109332 35.8195 µM 0.577364332620908 0.289204993312189 no 986 0.281846681661196 1314 17027281
SGTC_667 1498-1044 59 µM 0.576824907523627 0.289381765096979 no 987 0.282028870968446 1406 6739982
SGTC_2711 st079103 59.1 µM 0.575446376450325 0.289833745782387 no 988 0.282494723461967 1395 54693780
SGTC_413 propylparaben 100 µM 0.574661015360773 0.290091391076946 no 989 0.282760289003696 1326 7175 A pharmaceutical preservative.
SGTC_2035 5154463 94.595 µM 0.574406714636092 0.290174839887164 no 990 0.282846305096649 1417 2769623
SGTC_3345 9148410 3.559 µM 0.574145546276373 0.290260554017981 no 991 0.282934657215738 1373 4903596
SGTC_118 0083-0097 135.343 µM 0.572755349813528 0.290717008902577 no 992 0.283405177495599 1426 5207356
SGTC_937 3122-0005 46.7 µM 0.572608923633333 0.29076510577508 no 993 0.283454758137006 1381 759535
SGTC_150 3970-0969 77.2 µM 0.572047867605769 0.290949431296951 no 994 0.283644773007181 1428 6615640
SGTC_3028 9087778 49.47 µM 0.571771846396247 0.291040133457954 no 995 0.283738276494324 1310 17217395
SGTC_838 0109-0203 71.4 µM 0.57112183533822 0.291253783002664 no 996 0.283958529097529 1377 759422
SGTC_996 3970-0799 1.8 µM 0.568658274806453 0.292064184703324 no 997 0.284794034581523 1473 6615648 YGL040C HEM2
SGTC_1974 st069448 26.9 µM 0.564801407597109 0.293335025856662 no 998 0.286104424760948 1395 6323587 YNR016C ACC1
SGTC_912 3474-0017 2.18 µM 0.563759500133129 0.293678774409422 no 999 0.286458908910507 1474 3360550
SGTC_1874 staurosporine 7.6 µM 0.563480105088958 0.293770984770068 no 1000 0.286554001831845 1453 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1829 berberine 14.4 µM 0.563457822213149 0.293778339493094 no 1001 0.286561586518591 1470 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_182 3448-4371 550.524 µM 0.562571538127415 0.294070936949231 no 1002 0.286863338738621 1452 3491403
SGTC_1648 st011736 69.8 µM 0.561929634812593 0.294282938711577 no 1003 0.28708198086924 1444 2855514
SGTC_2886 9058944 51.95 µM 0.560889813726571 0.294626510705645 no 1004 0.287436327260593 1302 4949929
SGTC_1143 3454-2408 5.08 µM 0.560463607991398 0.294767388718664 no 1005 0.28758162782437 1351 X1143
SGTC_614 0462-0418 107 µM 0.559054297277692 0.295233443181517 no 1006 0.288062332151102 1306 5188303
SGTC_169 k015-0017 16.025 µM 0.558811943528149 0.295313622945261 no 1007 0.288145035225971 1472 1840002
SGTC_861 0443-0273 110 µM 0.557398864728841 0.295781322142677 no 1008 0.288627470486623 1426 6149169
SGTC_1670 st016595 4.04 µM 0.556392536007426 0.296114602989736 no 1009 0.288971270140185 1392 597879
SGTC_1043 0916-0009 19.3 µM 0.553769370454324 0.296984164716847 no 1010 0.289868346449301 1492 3101130
SGTC_1836 st055642 81 µM 0.552708664047938 0.297336113110118 no 1011 0.290231459825064 1335 8571
SGTC_3140 9094243 49.47 µM 0.549852884357359 0.298284622784111 no 1012 0.291210141234983 1404 19291112
SGTC_1185 1319-0113 81.3 µM 0.549312651641545 0.298464208819878 no 1013 0.291395453227526 1446 4672763
SGTC_874 0599-0792 117 µM 0.548741220474601 0.298654219474826 no 1014 0.291591526847775 1457 765305
SGTC_1570 verbenone 133 µM 0.54834882519813 0.29878472947248 no 1015 0.291726203984113 1459 29025 A natural terpanoid with antifungal properties.
SGTC_179 1273-0063 6.77 µM 0.546985808292516 0.299238267818712 no 1016 0.292194241054284 1381 3108139
SGTC_2762 leflunomide 42.06 µM 0.546879162016687 0.299273767107136 no 1017 0.292230876323623 1438 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1405 3909-7894 12 µM 0.546624594413449 0.299358512610588 no 1018 0.29231833435956 1474 7104060
SGTC_1840 st055363 71 µM 0.546361028378484 0.299446265155745 no 1019 0.292408896677701 1343 676033
SGTC_2398 5228213 48.84 µM 0.544983634721029 0.299905048753434 no 1020 0.292882386587677 1487 80771 YMR134W ERG29
SGTC_3253 9135987 49.47 µM 0.544840396277878 0.299952777008895 no 1021 0.292931646351104 1417 4182430
SGTC_27 0485-0001 32.618 µM 0.544419746108598 0.300092961053342 no 1022 0.293076330349206 1384 2054479
SGTC_2685 mycophenolic acid 18.85 µM 0.544230340076695 0.300156091357196 no 1023 0.293141487992634 1441 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1329 1447-1697 50.6 µM 0.541868985621516 0.300943650296488 no 1024 0.29395438180579 1412 2840515
SGTC_2778 tioconazole 65.09 nM 0.540601304787365 0.301366831216164 no 1025 0.294391209171752 1377 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1014 4130-3005 69.3 µM 0.539215867897712 0.301829627938803 no 1026 0.294868956304726 1407 743608
SGTC_771 0250-0039 27.3 µM 0.539094118633865 0.301870312799715 no 1027 0.294910956788157 1436 3005115
SGTC_2435 5706476 10.6 µM 0.535588032598866 0.303042994601178 no 1028 0.296121650743807 1467 5725375
SGTC_761 k216-0224 480 µM 0.534679772254772 0.303347112821739 no 1029 0.296435655569921 1564 1340404
SGTC_2737 bleomycin 30.5 nM 0.532537179792426 0.304065069600143 no 1030 0.297176999108715 1434 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_518 1021-0119 62.6 µM 0.532521833800883 0.304070214586763 no 1031 0.297182311924273 1387 1097762
SGTC_1260 0700-1617 7.75 µM 0.532442681252243 0.30409675234799 no 1032 0.297209715397768 1469 2853078
SGTC_107 0358-0022 2.6945 µM 0.53229528943095 0.30414617168725 no 1033 0.297260747127435 1499 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3161 9100388 49.47 µM 0.531259996331447 0.304493398261429 no 1034 0.297619311267935 1502 25236368
SGTC_992 3909-8734 162 µM 0.530776192931623 0.30465572136076 no 1035 0.297786939726957 1424 4288319
SGTC_886 0866-0150 153 µM 0.530154826042365 0.304864255448962 no 1036 0.298002294405873 1541 271463
SGTC_2905 7799065 20.05 µM 0.530063755161815 0.304894824657737 no 1037 0.298033863911631 1477 1296806
SGTC_3237 9133362 49.47 µM 0.529561450508705 0.305063454672188 no 1038 0.298208014012582 1487 43845137
SGTC_16 erodoxin 22.806 µM 0.52947886664078 0.305091183083 no 1039 0.298236650452371 1451 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2313 7726885 200 µM 0.52938475640019 0.305122782959951 no 1040 0.298269285255917 1430 726423
SGTC_957 1187-1561 14.1 µM 0.527594496400904 0.305724184202859 no 1041 0.298890406850489 1417 1538454
SGTC_618 k072-0232 33.2 µM 0.525059512150996 0.306576657096888 no 1042 0.299770910364143 1454 5872756 YGL099W LSG1
SGTC_988 1497-1057 103 µM 0.523160649428454 0.307215899533719 no 1043 0.300431231369341 1496 3533044
SGTC_2296 7971656 126.45 µM 0.521948115188066 0.30762439983834 no 1044 0.30085322817435 1435 666570
SGTC_1263 0774-1208 64.8 µM 0.52146656224875 0.30778670027692 no 1045 0.301020896597594 1554 906585
SGTC_1399 3562-5772 25 µM 0.520738942839675 0.308032005207604 no 1046 0.301274320992381 1415 23847490
SGTC_2217 6934799 96.0675 µM 0.520559071778612 0.308092659010611 no 1047 0.301336983545995 1482 675606
SGTC_3266 9136860 49.47 µM 0.520512195060551 0.308108467034929 no 1048 0.301353315179444 1398 4871271 YPR165W RHO1
SGTC_49 0717-0965 32.132 µM 0.519371249368158 0.308493332725975 no 1049 0.301750938243861 1527 5889349 YGL099W LSG1
SGTC_2724 maprotiline 69.64 µM 0.517192723453896 0.309228781209963 no 1050 0.302510815529816 1494 4011 A tricyclic antidepressant.
SGTC_708 3448-5400 146 µM 0.515313815625326 0.309863696294138 no 1051 0.303166873126235 1437 3462195
SGTC_1662 st014054 52 µM 0.514859249004665 0.310017387463964 no 1052 0.303325689535372 1441 2838777
SGTC_73 0327-0325 16.231 µM 0.513733265300795 0.310398230928246 no 1053 0.30371924556433 1476 53298
SGTC_2698 st077697 67.5 µM 0.511617000748306 0.311114568930729 no 1054 0.304459542406028 1408 3154499
SGTC_2486 5283202 22.39 µM 0.511474162881412 0.311162944191517 no 1055 0.304509537866668 1415 1377751
SGTC_474 dl-dihydrosphingosine 5 µM 0.510792802948066 0.311393746962251 no 1056 0.304748074628672 1502 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1746 st038117 42 µM 0.509287125841833 0.3119040404929 no 1057 0.30527549030367 1491 2898218
SGTC_1561 5-methoxyflavone 52.9 µM 0.507551372757341 0.312492758050381 no 1058 0.305884000068605 1452 94525
SGTC_1190 1486-1332 13 µM 0.50507469515307 0.313333604811077 no 1059 0.306753186899863 1436 4150046
SGTC_2834 9001755 58.44 µM 0.503497580517023 0.313869551088614 no 1060 0.307307240488196 1512 2989575
SGTC_3216 9129716 49.47 µM 0.503095718650496 0.31400617749979 no 1061 0.307448488333722 1410 8056934
SGTC_1887 st057648 70.8 µM 0.502303827264623 0.314275482137801 no 1062 0.307726908722063 1577 688672
SGTC_3128 9127691 49.47 µM 0.502083626667058 0.314350385039867 no 1063 0.307804348543226 1491 41316314
SGTC_1035 k081-0041 55.2 µM 0.500524571373948 0.314880928033516 no 1064 0.308352879560063 1481 731709
SGTC_2546 rhodinyl acetate 100 µM 0.499705519012384 0.315159802938028 no 1065 0.308641222902687 1521 6708682
SGTC_1245 0418-0076 17.2 µM 0.49970137586324 0.315161213885457 no 1066 0.30864268177808 1516 6790114
SGTC_3251 9135047 49.47 µM 0.498000948324471 0.315740521118567 no 1067 0.309241686886998 1565 17682963
SGTC_1564 D-Arginine 115 µM 0.497712352162647 0.315838886006741 no 1068 0.309343400300688 1401 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_872 0588-0139 234 µM 0.496044437556513 0.316407632053031 no 1069 0.309931529526831 1475 2047100
SGTC_3286 9117135 37.221 µM 0.492556829192179 0.317598282664474 no 1070 0.311162879054158 1428 3438150
SGTC_1669 st015249 58.4 µM 0.492454321262602 0.317633306954291 no 1071 0.311199103013239 1552 722793
SGTC_137 0438-0332 85.389 µM 0.491385613890031 0.317998553595852 no 1072 0.31157686862841 1453 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_718 1130-0073 349 µM 0.491077169084684 0.318104002145108 no 1073 0.311685934304985 1560 6740020
SGTC_1177 0983-0204 23.6 µM 0.490434057663457 0.318323911156462 no 1074 0.31191339078201 1555 766818
SGTC_828 2074-0507 139 µM 0.490230128918438 0.318393657035292 no 1075 0.311985531550511 1572 X828
SGTC_967 1306-0166 352 µM 0.489895400604271 0.318508151762501 no 1076 0.312103958925908 1582 4437607
SGTC_672 1441-0018 53.7 µM 0.489352600449555 0.318693854868791 no 1077 0.312296043706377 1458 251141
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.48923042320719 0.318735660499118 no 1078 0.312339286524786 1499 442882
SGTC_183 3914-0051 30.55 µM 0.487444474018215 0.31934702539394 no 1079 0.312971691482697 1627 1596232
SGTC_2350 9023895 38.85 µM 0.486830120688891 0.319557444100869 no 1080 0.313189361514194 1570 2997209
SGTC_2937 9044753 11.33 µM 0.486469417006705 0.319681013770347 no 1081 0.313317191898199 1447 6465530 YGL099W LSG1
SGTC_731 3966-0296 387 µM 0.486252861891228 0.319755210721287 no 1082 0.313393948006962 1510 660956
SGTC_2789 5281112 71.43 µM 0.485818553491394 0.319904036882198 no 1083 0.31354790926301 1455 765948
SGTC_666 0272-0154 136 µM 0.484320808027153 0.320417497461252 no 1084 0.314079105402337 1509 6870312
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.481389148854892 0.321423530517802 no 1085 0.315119973693562 1491 689007
SGTC_587 k089-0003 57 µM 0.481349058028892 0.321437297258263 no 1086 0.315134217908997 1505 9659696
SGTC_114 0364-0001 490.298 µM 0.48131294956032 0.321449696711749 no 1087 0.315147047433588 1440 4003655
SGTC_377 3970-0964 33.1 µM 0.479306212705337 0.322139111785226 no 1088 0.315860401523862 1552 16481235
SGTC_516 3992-2719 87.3 µM 0.479217026889144 0.322169765831005 no 1089 0.315892121214128 1412 5350887 YDR037W KRS1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.477339257688555 0.322815454227491 no 1090 0.316560280180355 1499 1241132 A phosphatase inhibitor.
SGTC_1654 st012436 41.8 µM 0.476122701329024 0.323234063911254 no 1091 0.316993482424772 1523 4323132
SGTC_534 k292-0788 63.4 µM 0.475892430548479 0.323313323912684 no 1092 0.317075507564869 1587 4146317
SGTC_2533 agelasine 13.65 µM 0.475063161013102 0.323598827789565 no 1093 0.317370977506977 1672 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2953 9074162 66.49 µM 0.474312429722029 0.32385738182413 no 1094 0.317638564570181 1654 16451992
SGTC_1895 st058434 18.3 µM 0.473877114799952 0.32400734449681 no 1095 0.317793769793422 1613 5393175
SGTC_818 4072-2707 53.5 µM 0.473625192885733 0.32409414272688 no 1096 0.317883603527455 1454 882871
SGTC_2820 7989630 71.43 µM 0.473303281691204 0.324205069273245 no 1097 0.317998410588065 1510 2984098
SGTC_145 3737-0113 38.366 µM 0.472477073771389 0.324489841534681 no 1098 0.318293151099021 1584 6849351
SGTC_3202 9113761 49.47 µM 0.472310842709509 0.324547149444431 no 1099 0.318352466097505 1676 4798415
SGTC_485 niflumic acid 177 µM 0.472158442773278 0.324599692744903 no 1100 0.318406849929948 1556 4488 A COX2 inhibitor.
SGTC_1313 1220-0047 237 µM 0.467755448668381 0.326119227739937 no 1101 0.319979741767629 1583 3528706
SGTC_2756 carbadox 75.1 µM 0.465890467188447 0.326763732329696 no 1102 0.320646952487673 1495 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_617 3770-0098 35 µM 0.463911485795317 0.327448198954901 no 1103 0.321355581704477 1545 5962639
SGTC_2241 6772625 37.8075 µM 0.463765719233762 0.32749863794427 no 1104 0.321407803230728 1486 2285411
SGTC_2394 5221648 200 µM 0.463425111339295 0.327616509333255 no 1105 0.321529841301863 1683 788586
SGTC_650 1328-0195 38 µM 0.463389795970425 0.327628731617498 no 1106 0.321542495720844 1561 2780821
SGTC_1029 k015-0030 64.7 µM 0.461908742083139 0.32814147522798 no 1107 0.322073382311358 1583 2208316
SGTC_2491 paeonol 100 µM 0.461733682927815 0.328202102462779 no 1108 0.3221361566266 1505 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1073 triclabendazole 3.09 µM 0.461538428933383 0.328269728999393 no 1109 0.32220617857826 1569 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_724 3910-0327 137 µM 0.460511759600204 0.328625410138058 no 1110 0.322574466323111 1502 2885483
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.458554054408419 0.329304071244284 no 1111 0.323277218523066 1504 4000243
SGTC_440 fluspirilene 35.1 µM 0.457432253555374 0.329693210261008 no 1112 0.323680192964151 1631 3396 An atypical antipsychotic.
SGTC_531 3788-1495 174 µM 0.456578320923938 0.329989552729149 no 1113 0.323987082182827 1524 2896655
SGTC_541 4513-1321 94 µM 0.455596968288986 0.330330245881832 no 1114 0.324339911819574 1495 747515
SGTC_600 1495-0418 41.6 µM 0.455287060469419 0.330437864863828 no 1115 0.32445136701177 1551 5377768
SGTC_1877 wortmannin 25 µM 0.455235873353315 0.330455641516321 no 1116 0.324469777450516 1609 312145 A covalent inhibitor of PI 3-kinase.
SGTC_299 1273-0059 1.44 µM 0.454726409222457 0.330632592956446 no 1117 0.324653039480815 1552 2848077
SGTC_913 3487-1245 167 µM 0.45382902660091 0.330944371628995 no 1118 0.324975944959804 1475 4016153
SGTC_2848 9016370 25.97 µM 0.453329756366174 0.331117884451352 no 1119 0.325155654490322 1647 7894410
SGTC_757 1066-0008 322 µM 0.452177791415207 0.331518368494875 no 1120 0.325570452985796 1607 6842497
SGTC_2336 9001819 198.65 µM 0.449890186752003 0.332314232004861 no 1121 0.3263948119028 1646 2989602
SGTC_2097 5376186 200 µM 0.44844524828389 0.33281731999862 no 1122 0.326915946105396 1623 742755
SGTC_3244 9134489 49.47 µM 0.448237064408071 0.332889828762385 no 1123 0.326991057950944 1498 16584271
SGTC_3107 9121808 49.47 µM 0.447231131648771 0.333240275037715 no 1124 0.327354092871886 1569 662681
SGTC_331 k048-0133 24.5 µM 0.445473436509049 0.33385296929289 no 1125 0.327988826122615 1538 6813582
SGTC_3271 9137798 49.47 µM 0.444865384430012 0.334065026276479 no 1126 0.328208519775057 1652 6498326
SGTC_637 1181-0519 7.26 µM 0.44186539190673 0.335112042370548 no 1127 0.329293307723019 1554 6252091 YGR060W ERG25
SGTC_2063 5246145 200 µM 0.438585274450318 0.336258291605191 no 1128 0.330481034448029 1616 711240
SGTC_376 3970-0862 59.1 µM 0.438464510771558 0.33630052207044 no 1129 0.330524795534832 1666 3135186
SGTC_5 0352-0601 109.883 µM 0.438186369170074 0.336397794678898 no 1130 0.330625594411398 1574 762456
SGTC_3201 9113999 49.47 µM 0.436141729927441 0.337113188524892 no 1131 0.331366951022614 1652 16649224
SGTC_489 paxilline 115 µM 0.436015155125728 0.337157494875369 no 1132 0.331412866980065 1527 105008 A toxic potassium channel blocker.
SGTC_3116 9124943 49.47 µM 0.435485195342191 0.337343026967089 no 1133 0.331605141371384 1487 41905195 YPL160W CDC60
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.434723789679243 0.337609654514229 no 1134 0.331881464177311 1653 16725076
SGTC_594 1487-1584 10.8 µM 0.434042093253053 0.337848438821573 no 1135 0.332128937209948 1522 5013332
SGTC_2397 5161689 200 µM 0.432984974507651 0.338218854952052 no 1136 0.332512842836589 1649 2259942
SGTC_1540 guanosine 70.6 µM 0.43260300252279 0.33835273710374 no 1137 0.332651603889693 1613 6802 Guanosine is a purine nucleoside
SGTC_3206 9114350 49.47 µM 0.431041896934579 0.338900120884192 no 1138 0.333218953454265 1547 17087243
SGTC_906 1165-0455 526 µM 0.430678151437537 0.33902771300538 no 1139 0.333351203672543 1540 3252859
SGTC_1445 4239-0156 97.7 µM 0.430082653431973 0.339236637520858 no 1140 0.333567758952379 1715 4008346
SGTC_1271 0832-2808 169 µM 0.426824674731381 0.340380540383454 no 1141 0.334753516447997 1695 3663794
SGTC_1363 1636-0063 10.4 µM 0.425022021414591 0.341014099164591 no 1142 0.335410310781154 1590 6072185
SGTC_1485 3909-9022 254 µM 0.423023863322832 0.341716894042318 no 1143 0.336138925206868 1588 714516
SGTC_1225 1216-0074 20.6 µM 0.422609675532079 0.341862641507797 no 1144 0.336290033072315 1571 4241466
SGTC_2377 9073351 62.6 µM 0.42225290250826 0.341988204338371 no 1145 0.336420215552174 1559 7337946 YHR072W ERG7
SGTC_2600 tangeritin 87.95 µM 0.42166769566996 0.342194200091504 no 1146 0.336633793436205 1519 68077 A bioactive flavone.
SGTC_1960 st011366 51.8 µM 0.420726233551887 0.342525698038961 no 1147 0.336977501314804 1584 3972846
SGTC_588 3970-1144 52.9 µM 0.420005454992529 0.342779573185812 no 1148 0.337240734345382 1655 1888707
SGTC_2923 7992654 58.14 µM 0.419885509540529 0.342821827688147 no 1149 0.337284546944847 1596 2985126
SGTC_1145 3546-0597 10.2 µM 0.419397346873551 0.342993818395739 no 1150 0.337462881387512 1590 875334
SGTC_663 1486-0733 13.9 µM 0.419162538254451 0.343076558354731 no 1151 0.337548674130755 1598 722445 YPR165W RHO1
SGTC_2890 9046729 58.44 µM 0.418710164429648 0.343235983388046 no 1152 0.3377139831408 1529 903329
SGTC_1875 nocodazole 6 µM 0.415600768937984 0.344332546490314 no 1153 0.338851081960874 1664 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_604 1000-0114 314 µM 0.415060732863106 0.344523130014818 no 1154 0.339048722037775 1696 1572745
SGTC_3198 9112019 49.47 µM 0.414470738722824 0.344731389306268 no 1155 0.339264696193719 1626 45595555
SGTC_2742 clothiapine 36.27 µM 0.4132107806532 0.34517629355055 no 1156 0.339726095132668 1688 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_816 0325-0417 81.3 µM 0.412765276724859 0.345333656861841 no 1157 0.339889297013752 1578 68101
SGTC_1360 1598-0022 39.8 µM 0.411721939823945 0.345702294579475 no 1158 0.340271621025404 1700 761525
SGTC_2524 avocatin b 10.57 µM 0.410417911024979 0.346163247181641 no 1159 0.340749704807489 1688 6710748
SGTC_1380 2291-0730 164 µM 0.409775305700857 0.346390481438327 no 1160 0.340985391316495 1577 2999191
SGTC_3262 9137218 49.47 µM 0.407503869699737 0.347194135782945 no 1161 0.341818976287224 1580 17650664
SGTC_2649 anisomycin 9.56 µM 0.407319017309984 0.347259568514031 no 1162 0.341886848521955 1617 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1814 st052110 31.539 µM 0.407260073909554 0.347280433836146 no 1163 0.341908491839501 1717 674163
SGTC_3302 9125395 16.351 µM 0.406547943170953 0.347532556927081 no 1164 0.342170018839662 1645 17599668
SGTC_96 0929-0093 37.281 µM 0.404039508263671 0.348421181049299 no 1165 0.343091833367411 1587 6991579
SGTC_2335 9018011 154.17 µM 0.402325775834595 0.349028757362694 no 1166 0.343722143656693 1722 6458208
SGTC_202 3594-0513 34.79 µM 0.401280276731019 0.349399612571567 no 1167 0.344106891533408 1644 708429
SGTC_1092 toremifene 6.32 µM 0.400418729255479 0.349705325308388 no 1168 0.344424065825866 1627 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2839 9003951 25.97 µM 0.40004861083634 0.349836688603148 no 1169 0.344560356644208 1662 2990634
SGTC_193 1273-0060 1.558 µM 0.399538752144905 0.350017678279359 no 1170 0.34474813786679 1612 2847393 YHR072W ERG7
SGTC_3018 9082602 49.47 µM 0.398883659279528 0.350250273210296 no 1171 0.344989465060549 1630 17332089
SGTC_397 arbidol 50 µM 0.397626396259401 0.350696829833785 no 1172 0.345452800048627 1719 131410 A RNA synthesis inhibitor.
SGTC_1908 st060353 56.5 µM 0.397391316382445 0.350780348786378 no 1173 0.345539458988041 1817 4227716
SGTC_3281 9140613 49.47 µM 0.395989668317134 0.351278474525287 no 1174 0.346056325031422 1542 16013766
SGTC_943 3253-1379 105 µM 0.394995623055736 0.351631899002348 no 1175 0.346423059092399 1713 668464
SGTC_803 4488-1585 147 µM 0.394761487875545 0.351715162483874 no 1176 0.346509459774439 1707 747204
SGTC_2204 7233102 200 µM 0.394600103280726 0.351772558441723 no 1177 0.346569018648583 1670 2172480
SGTC_2013 4024628 200 µM 0.394379629262581 0.351850974839905 no 1178 0.346650390564013 1669 5230760
SGTC_2710 st078562 53.7235 µM 0.393190804607699 0.35227391482187 no 1179 0.34708928039695 1569 17250908
SGTC_1933 st074711 15.9 µM 0.393018518172775 0.352335223157814 no 1180 0.347152902073553 1593 17250958
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.392003914146257 0.35269634901682 no 1181 0.347527660865226 1683 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2659 sanguinarine 24.21 µM 0.39151396697726 0.352870782434371 no 1182 0.347708683393928 1638 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1257 0669-0121 16 µM 0.388598989758951 0.35390922538788 no 1183 0.348786407106043 1757 4307855
SGTC_2163 5671233 125 µM 0.388449788028986 0.353962406925972 no 1184 0.348841602811374 1743 701023
SGTC_3228 9131799 49.47 µM 0.387628213060018 0.354255300528568 no 1185 0.349145593630857 1670 17015818
SGTC_1451 4152-0210 104 µM 0.385279874423925 0.355092964325084 no 1186 0.350015035347907 1752 659563
SGTC_814 3342-0569 96 µM 0.385048364141175 0.355175583182393 no 1187 0.350100791691062 1671 4346283
SGTC_2532 xanthone 78.9 µM 0.383944744374846 0.355569524462261 no 1188 0.35050970099324 1720 7020 An insecticide.
SGTC_1211 1056-0033 32.3 µM 0.383083507142614 0.355877053611863 no 1189 0.350828923986062 1746 6741922
SGTC_1337 1486-1011 40.3 µM 0.382120759468648 0.356220940981168 no 1190 0.351185897145136 1620 X1337
SGTC_830 4076-0286 57.8 µM 0.381808281415406 0.356332581319198 no 1191 0.351301787815865 1684 6866659
SGTC_619 1652-1634 108 µM 0.379784191528578 0.357056034204099 no 1192 0.352052809010986 1646 5400454
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.379574412493858 0.357131043159892 no 1193 0.352130678798446 1727 17037758
SGTC_22 0964-0034 14.468 µM 0.376596039064474 0.358196590040136 no 1194 0.35323691589537 1636 138402
SGTC_117 lucigenin 22.078 µM 0.376000866452732 0.358409652573513 no 1195 0.353458125935632 1579 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1096 rimcazole 32.2 µM 0.375523747007407 0.358580485751511 no 1196 0.353635494468058 1663 18528119 A dopamine reuptake inhibitor.
SGTC_1116 jasmonic acid 1.58368 µM 0.374279813972747 0.359026010441513 no 1197 0.35409807431314 1729 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1885 st057546 99.9 µM 0.37419738107048 0.359055541236315 no 1198 0.354128736152358 1753 702008
SGTC_124 0136-0217 7.121 µM 0.37406813251653 0.359101844983795 no 1199 0.354176813500407 1744 3976905
SGTC_3118 9124250 49.47 µM 0.373330513156986 0.35936613930141 no 1200 0.354451234596559 1645 1504786
SGTC_2084 5306078 60.6385 µM 0.371600944685548 0.359986119834505 no 1201 0.355094992814568 1721 679340
SGTC_571 k831-0106 44.2 µM 0.371437698938781 0.360044655907645 no 1202 0.355155775494383 1775 4783639
SGTC_2773 thioridazine 9.09 µM 0.369123352336094 0.360874878492337 no 1203 0.35601789174408 1693 5452 An antipsychotic.
SGTC_1553 gossypol 38.6 µM 0.368362356261328 0.361148013145148 no 1204 0.356301531225322 1661 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_4 0960-0234 25.671 µM 0.368302937296333 0.361169342621249 no 1205 0.356323681290714 1655 6821112
SGTC_3036 9090181 49.47 µM 0.367205299538009 0.361563436450772 no 1206 0.356732943289491 1685 25236586
SGTC_946 3434-1334 87.4 µM 0.367012895750362 0.361632531894478 no 1207 0.356804699409337 1733 4047976
SGTC_616 4092-0450 108 µM 0.366734865963631 0.361732385048187 no 1208 0.356908398308154 1712 787165
SGTC_3094 9117742 49.47 µM 0.365398088060698 0.362212614203413 no 1209 0.357407134118238 1614 17149698
SGTC_2474 5321570 43.32 µM 0.365386550492076 0.362216759948634 no 1210 0.357411439708507 1767 2841384
SGTC_2989 9073649 71.4286 µM 0.365133849373458 0.362307566014313 no 1211 0.357505747272526 1805 21367202
SGTC_715 0868-0130 184 µM 0.365021380443347 0.362347983290037 no 1212 0.357547723256332 1831 2876258
SGTC_1609 st001574 46.4 µM 0.363767150614253 0.362798812114613 no 1213 0.358015947250188 1646 3960012
SGTC_2985 9022375 71.43 µM 0.363427746177258 0.36292084266581 no 1214 0.358142689099626 1679 4939335
SGTC_2955 9076254 12.21 µM 0.363054965557938 0.363054889436988 no 1215 0.358281912440859 1811 16459619
SGTC_1102 cgs 12066b 26.1 µM 0.36297148092278 0.363084911660842 no 1216 0.358313094246471 1712 6438352 A 5-HT1B full agonist.
SGTC_1846 st056244 14.8 µM 0.362840827694081 0.363131898048733 no 1217 0.358361895584544 1726 5393182
SGTC_976 1348-1067 47.6 µM 0.361712252302882 0.363537849558402 no 1218 0.358783535081178 1676 5310671 YGL099W LSG1
SGTC_3354 9151612 71.43 µM 0.360892509822641 0.363832809194353 no 1219 0.359089901545006 1790 27261949
SGTC_2471 5466956 24.79 µM 0.360506339417651 0.363971788957588 no 1220 0.359234258366221 1720 724419
SGTC_2070 5230947 200 µM 0.360009797752075 0.364150516785411 no 1221 0.35941990330506 1763 2835538
SGTC_2608 thymoquinone 42.66 µM 0.359435523163542 0.364357261061119 no 1222 0.359634652093211 1677 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2561 acetosyringone 100 µM 0.359242045446649 0.364426923758601 no 1223 0.359707012670039 1676 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_350 k064-0020 19.8 µM 0.359193413834834 0.364444434537588 no 1224 0.359725201661502 1806 2790705
SGTC_3105 9121040 49.47 µM 0.358945458510607 0.364533720180852 no 1225 0.359817945810902 1706 41448907
SGTC_1021 4476-0760 85.3 µM 0.356968918508069 0.365245710209182 no 1226 0.360557537137344 1632 746768
SGTC_2292 7671323 168.05 µM 0.356805219446271 0.365304698821973 no 1227 0.360618814288106 1666 937504
SGTC_2034 5197015 53.07 µM 0.356568801207215 0.36538989726173 no 1228 0.360707318583736 1799 780676
SGTC_880 0833-0487 87.2 µM 0.355862899009305 0.36564432394197 no 1229 0.360971620819498 1658 76075
SGTC_1781 st038725 66.3 µM 0.355113394846841 0.365914530685292 no 1230 0.361252321078544 1677 4270275 YIL048W NEO1
SGTC_3351 9150312 21.596 µM 0.354550640325326 0.366117455303086 no 1231 0.361463129989812 1699 4904905
SGTC_966 1300-0360 30.2 µM 0.352534567581884 0.366844741489577 no 1232 0.36221869954592 1682 70588
SGTC_1338 1486-1223 76 µM 0.351296551797926 0.367291585460056 no 1233 0.362682940786886 1769 3444526
SGTC_2094 5332512 191.667 µM 0.350710401854235 0.367503210591181 no 1234 0.362902810546066 1794 755774
SGTC_2040 5100729 123 µM 0.350670622301195 0.367517574165538 no 1235 0.362917733828707 1750 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2155 5570423 76 µM 0.350079242749349 0.367731130946437 no 1236 0.363139614160002 1693 797402
SGTC_1637 st007924 17.4 µM 0.347766377724861 0.368566736368873 no 1237 0.364007821027302 1678 683336
SGTC_3109 9122853 49.47 µM 0.346816635964616 0.368910044981451 no 1238 0.364364539134688 1747 1234709
SGTC_800 3448-7362 155 µM 0.346756342903251 0.368931842995327 no 1239 0.364387188867615 1758 15991913
SGTC_129 0088-0017 176.636 µM 0.346694154577304 0.368954326654162 no 1240 0.364410551073044 1814 182446
SGTC_936 3005-4620 401 µM 0.346496114305237 0.369025929412973 no 1241 0.364484951953513 1815 777207
SGTC_2804 7954240 19.48 µM 0.345831159335762 0.36926638148236 no 1242 0.364734803303793 1799 828705
SGTC_3287 9117173 37.0625 µM 0.344439741850601 0.369769692574215 no 1243 0.365257802766176 1741 2789709
SGTC_796 1234-0020 70.7 µM 0.34429490773061 0.369822095598548 no 1244 0.365312256756252 1663 46495034
SGTC_2869 9037858 32.47 µM 0.344123688664443 0.369884048186143 no 1245 0.365376634325609 1657 27187042
SGTC_822 1487-0950 154 µM 0.342393450944589 0.370510293312078 no 1246 0.366027408194502 1832 1958375
SGTC_2259 7964009 200 µM 0.341739787830517 0.370746970665964 no 1247 0.366273363237618 1766 313134
SGTC_92 0063-0024 660.874 µM 0.341669232613287 0.370772520119066 no 1248 0.366299914468482 1792 3594437
SGTC_2453 5731132 22.18 µM 0.341368288631627 0.370881504342023 no 1249 0.366413172431047 1854 1362040
SGTC_2278 7948257 134.34 µM 0.340544507722434 0.371179882335482 no 1250 0.366723255559159 1876 1247028
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.340334159995548 0.371256083863777 no 1251 0.36680244745741 1789 688751
SGTC_2451 5856223 45.7 µM 0.338545965582354 0.371904086895039 no 1252 0.367475897119869 1677 2179896
SGTC_523 1934-0222 13.7 µM 0.338512393653268 0.371916256114415 no 1253 0.367488544508202 1689 1361595
SGTC_314 1671-0008 2.74 µM 0.338261603784139 0.372007166970569 no 1254 0.367583027893089 1726 3913060
SGTC_1365 1672-3266 55.4 µM 0.338126629565166 0.372056097825272 no 1255 0.367633881834269 1822 6415873
SGTC_2595 hexamethylquercetagetin 100 µM 0.337858716092383 0.372153227939401 no 1256 0.367734829882074 1731 386331
SGTC_417 st075190 100 µM 0.337773787710535 0.37218401981546 no 1257 0.367766832249794 1841 222757
SGTC_1689 st020265 53.493 µM 0.337705028877527 0.372208949812537 no 1258 0.367792742346348 1827 5758320 YPR016C TIF6
SGTC_2846 9008642 19.48 µM 0.337422336056413 0.372311451815403 no 1259 0.367899274591889 1694 2992898
SGTC_171 k064-0041 9.68 µM 0.337240234302197 0.372377485147734 no 1260 0.367967904669483 1659 53325
SGTC_1664 st014217 9.02 µM 0.334851363173806 0.373244079075216 no 1261 0.368868606317565 1777 3982782
SGTC_1760 st045453 10.4495 µM 0.333784750027443 0.373631214252635 no 1262 0.369270995914854 1846 3323419 YIL048W NEO1
SGTC_320 4092-0846 5.34 µM 0.332144659372764 0.374226746098733 no 1263 0.369890014574088 1790 1359356
SGTC_3159 9100096 49.47 µM 0.332007980974186 0.37427638884218 no 1264 0.369941616285327 1679 25236875
SGTC_152 4469-0003 551.229 µM 0.330775168950698 0.374724250641347 no 1265 0.370407159189031 1840 697280
SGTC_2946 9065502 71.43 µM 0.330419259997702 0.374853578402976 no 1266 0.370541595310259 1714 16489101
SGTC_2898 9056270 58.44 µM 0.329023882997475 0.375360756593658 no 1267 0.37106881806615 1748 19154699
SGTC_3183 9108214 49.47 µM 0.328013987265797 0.375727958256578 no 1268 0.371450543447108 1799 4974831
SGTC_1420 4'-methoxyflavone 42 µM 0.325487553923268 0.376647070821472 no 1269 0.372406050397033 1863 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_106 0092-0003 11.579 µM 0.324149647660038 0.377134082775718 no 1270 0.37291237046729 1864 1072148
SGTC_1277 0873-0036 22 µM 0.321371911677099 0.378145831424645 no 1271 0.373964283160499 1825 5965735
SGTC_2903 5923464 63.88 µM 0.320103406022627 0.378608144127887 no 1272 0.374444971886043 1852 2876576
SGTC_3196 9111891 49.47 µM 0.319556620334092 0.378807476317523 no 1273 0.374652231621698 1757 18891510
SGTC_1114 scopoletin 1.73284 µM 0.319172677154502 0.378947463104689 no 1274 0.374797787367176 1861 5280460 A coumarin with genotoxic properties.
SGTC_3061 glucosamine 200 µM 0.317524083356644 0.379548725410265 no 1275 0.375422984166586 1873 91431 and experimental redox chemotherapeutic
SGTC_1508 1080-0625 72.9 µM 0.317071088902818 0.379713989119856 no 1276 0.375594830808485 1768 767111
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.312360166644945 0.381433948692149 no 1277 0.377383409661809 1847 688662
SGTC_199 4063-0024 41.6 µM 0.311804047255969 0.381637143450557 no 1278 0.377594724011547 1845 306215
SGTC_968 1309-0633 340 µM 0.311229247311128 0.381847197989408 no 1279 0.377813175113946 1877 3761976
SGTC_2653 dihydrofissinolide 100 µM 0.309154398108048 0.382605718655606 no 1280 0.378602040409381 1800 6857746
SGTC_1268 0828-0275 2.46 µM 0.30887824660459 0.382706707799978 no 1281 0.378707072461396 1834 745337
SGTC_1919 st067113 52.3 µM 0.305200218576437 0.384052527850589 no 1282 0.380106832971445 1741 1268243
SGTC_1458 k015-0034 6.33 µM 0.304438800658202 0.384331312159613 no 1283 0.380396805548058 1699 3598957
SGTC_1053 3366-3204 134 µM 0.300907883379023 0.38562489651838 no 1284 0.381742369349669 1705 3632071 YPR165W RHO1
SGTC_1402 3909-7673 35.9 µM 0.299924755425781 0.385985301802761 no 1285 0.382117275498707 1754 5328014
SGTC_2258 7960471 200 µM 0.29726456396083 0.386960995155274 no 1286 0.383132266668085 1764 2974708
SGTC_1282 0886-0010 32.4 µM 0.297208517131802 0.386981559474781 no 1287 0.383153659892592 1929 2836211 YNL267W PIK1
SGTC_920 mycophenolic acid 780.421 nM 0.296658730630586 0.387183300192387 no 1288 0.383363533753955 1747 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_563 tetrahydrosecaminediol 614 µM 0.295956712143045 0.387440945781294 no 1289 0.383631569956201 1904 334274 A psychoactive constituent of the cannabis plant.
SGTC_1779 st039427 55 µM 0.293537387831875 0.388329233570272 no 1290 0.384555713030776 1970 1124498
SGTC_1058 3448-5425 97.3 µM 0.293051871520705 0.3885075680398 no 1291 0.384741251728197 1872 7279705
SGTC_2248 tofa 1.1 µM 0.292752405805051 0.388617576188827 no 1292 0.384855704878434 1814 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.290857127767996 0.38931400973643 no 1293 0.385580295725783 1871 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1748 st037455 53.6035 µM 0.2906454299722 0.389391821738449 no 1294 0.385661255553551 1821 580690
SGTC_850 0388-0143 75.9 µM 0.288330588285776 0.39024295764094 no 1295 0.386546847410775 1787 67273
SGTC_933 2914-0560 114 µM 0.287911008657771 0.390397287850705 no 1296 0.386707429936142 1960 463887
SGTC_2448 5185112 27.17 µM 0.287567340353153 0.39052370914796 no 1297 0.386838973950748 1787 5718189
SGTC_3184 9108758 49.47 µM 0.28651994065328 0.390909075343039 no 1298 0.387239961466637 1813 902885
SGTC_2505 galangin 7.89 µM 0.285912239670876 0.391132713835307 no 1299 0.387472669497942 1745 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2446 5162541 200 µM 0.284838339218287 0.391528005189036 no 1300 0.387883998948823 1763 1549321
SGTC_2754 granisetron 64.02 µM 0.282460728920336 0.39240357636542 no 1301 0.388795127417632 1920 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_676 falcarinol 140 µM 0.279080921328988 0.393649150493333 no 1302 0.390091362124447 1926 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2354 9060492 162 µM 0.279051776129771 0.393659896245219 no 1303 0.390102545324536 1909 6471895
SGTC_2763 lisinopril 49.32 µM 0.279043930144706 0.393662789051387 no 1304 0.390105555894925 1930 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2933 9026794 32.47 µM 0.276789598229132 0.394494201271811 no 1305 0.390970834331816 1853 17586027
SGTC_216 k038-0035 28.382 µM 0.276503304582594 0.394599822713464 no 1306 0.391080760930057 1914 4444231 YPR107C YTH1
SGTC_586 0957-0265 8.15 µM 0.276500361987773 0.394600908356238 no 1307 0.391081890827216 1918 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.276234715040588 0.394698919678708 no 1308 0.391183897692413 1813 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2861 9024595 19.48 µM 0.276037171883239 0.394771808203525 no 1309 0.391259757956261 1935 16482810
SGTC_1808 st050063 61.5 µM 0.275983820006097 0.394791494354592 no 1310 0.391280246783653 1904 4011993
SGTC_3178 9107506 49.47 µM 0.275532191652352 0.394958150119529 no 1311 0.391453698598301 1858 8897194
SGTC_1791 st048313 56.1 µM 0.275022481678001 0.395146261718387 no 1312 0.3916494830929 1944 1204976
SGTC_1074 carmofur 3.8 µM 0.27479638977308 0.395229710152784 no 1313 0.391736335954548 1831 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_729 4092-0585 94.1 µM 0.274220817183124 0.395442170359018 no 1314 0.391957465635546 1761 2169061
SGTC_1047 2043-3044 82 µM 0.271988485001916 0.396266481120754 no 1315 0.392815436669154 1768 669592
SGTC_479 n-linoleoylglycine 10 µM 0.270687355726248 0.396747150259803 no 1316 0.393315751272825 1831 6433346 An anti-infammatory.
SGTC_61 0978-8327 98.565 µM 0.270264490227315 0.39690340099484 no 1317 0.393478390921063 1970 6150059 YHR072W ERG7
SGTC_1761 st044296 37 µM 0.269996641592225 0.397002380854486 no 1318 0.393581418656619 1794 1826700
SGTC_2466 5983409 37.09 µM 0.268740143337345 0.397466791350228 no 1319 0.394064828924238 1816 2879657
SGTC_727 3032-0951 202 µM 0.267736561453651 0.397837826660553 no 1320 0.394451052449947 1855 3652836
SGTC_869 0564-0080 44.1 µM 0.267431281100009 0.39795071052892 no 1321 0.394568558689225 1779 6843321
SGTC_38 0929-0051 58.268 µM 0.265823484665217 0.398545368043119 no 1322 0.395187577791769 1983 1379719
SGTC_2146 5545642 200 µM 0.265639770514277 0.398613331348573 no 1323 0.395258326610406 1909 825326
SGTC_983 1491-0821 12.2 µM 0.265162292359209 0.398789984233623 no 1324 0.395442220888067 1935 46495113
SGTC_1973 st070275 50.2 µM 0.263541550220233 0.399389765637811 no 1325 0.396066601307822 1954 17118334
SGTC_3125 9127534 49.47 µM 0.26219007332589 0.399890082851472 no 1326 0.396587453055425 1951 1639235
SGTC_10 0279-0212 42.575 µM 0.259586642995757 0.400854336349075 no 1327 0.397591320283005 1841 39851 YBR002C RER2
SGTC_205 1486-1330 71.903 µM 0.259336140468869 0.400947148958044 no 1328 0.397687948458 1866 4118834
SGTC_2158 5657123 3.6195 µM 0.258660925485319 0.401197347776103 no 1329 0.397948435329691 1943 2858827
SGTC_875 0709-0210 25.7 µM 0.257717942525234 0.401546834980325 no 1330 0.398312298813522 2002 6251364
SGTC_2356 9061756 188.97 µM 0.256282012812862 0.402079168719685 no 1331 0.398866542631116 1973 20104043
SGTC_1666 st014829 29 µM 0.255316806400491 0.402437096165636 no 1332 0.399239210182416 1832 3858230
SGTC_1766 st045414 44.774 µM 0.25438579589536 0.402782420261902 no 1333 0.399598761675108 1862 253960
SGTC_1206 3978-0017 132 µM 0.252214370308232 0.403588125040143 no 1334 0.4004376855761 1920 3873677
SGTC_1513 0337-0559 19 µM 0.251533334887467 0.403840906875521 no 1335 0.400700896459145 1787 775073
SGTC_208 k072-0098 12.366 µM 0.250988098630711 0.404043312709066 no 1336 0.400911655328489 1916 5948901
SGTC_382 3229-0966 23.2 µM 0.250836565780246 0.404099570196465 no 1337 0.400970234863451 1952 5722370
SGTC_1302 1159-0335 255 µM 0.250232975315413 0.404323676481896 no 1338 0.40120359281479 1829 649284
SGTC_1773 st048542 73.5835 µM 0.249527411643694 0.404585684060241 no 1339 0.40147641995525 1792 3237138
SGTC_1419 3993-2473 62.6 µM 0.248195140004409 0.405080533136709 no 1340 0.401991713224697 1889 704026
SGTC_2952 9073731 13.78 µM 0.24802537870839 0.405143598931302 no 1341 0.402057385406575 1813 16457353
SGTC_285 1486-1325 46 µM 0.246783052735364 0.405605194047476 no 1342 0.402538063436566 1952 22310230
SGTC_2798 7813637 45.45 µM 0.245746833494578 0.40599030919191 no 1343 0.402939107873505 1902 956368
SGTC_2564 betulinic acid 100 µM 0.244773955933409 0.406351965965969 no 1344 0.403315730365012 2058 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_611 3453-1652 23.7 µM 0.243988634954415 0.406643958898435 no 1345 0.403619810983457 1977 1560575
SGTC_2543 pimpinellin 60.67 µM 0.24093697283668 0.407779099420789 no 1346 0.404801982948335 1829 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_550 4123-0385 25.7 µM 0.238926779422025 0.408527263945591 no 1347 0.405581179929578 1869 5731123
SGTC_3117 9124945 49.47 µM 0.238798950952878 0.408574851135024 no 1348 0.405630741860257 1790 17592065
SGTC_2716 st080858 38.6235 µM 0.23842423149258 0.408714357136248 no 1349 0.405776037615393 1975 5296050
SGTC_1315 1237-0019 3.69 µM 0.236859233121555 0.409297122291607 no 1350 0.406382998674604 1997 825140
SGTC_1286 0929-0070 131 µM 0.236509487986669 0.409427385844578 no 1351 0.406518672874389 1948 1420408
SGTC_1105 epirubicin 18.1 µM 0.236201520119644 0.409542097617955 no 1352 0.406638150001796 1846 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1191 1487-1166 10.6 µM 0.235065367228388 0.409965358402038 no 1353 0.407078999275353 1956 3955771
SGTC_1992 st073643 23.3 µM 0.233995027683362 0.410364197173454 no 1354 0.407494419427893 1874 3161292
SGTC_1930 st074634 34.3 µM 0.232406050154147 0.410956466012379 no 1355 0.408111325109813 1789 684253 YOR116C RPO31
SGTC_2009 4012297 12.05 µM 0.231083910459418 0.411449429662024 no 1356 0.408624807232426 1865 45595307
SGTC_2725 haloperidol 53.21 µM 0.23081933238028 0.411548095187564 no 1357 0.408727580835569 1973 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3086 9117350 49.47 µM 0.230230971011119 0.411767524879119 no 1358 0.408956148402164 1917 2679265
SGTC_157 1348-1695 65.819 µM 0.229722500715064 0.411957181383444 no 1359 0.409153704701968 1866 5380510
SGTC_235 0330-0087 5 mM 0.22938748788996 0.412082150488298 no 1360 0.409283880070441 1893 46494818 YHR062C RPP1
SGTC_1990 st072050 59.8 µM 0.228960311409515 0.412241512132046 no 1361 0.409449881824089 1840 17233948
SGTC_250 brefeldin a 552.239 µM 0.228656918792709 0.412354703993757 no 1362 0.40956779074901 1912 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2417 cerulenin 830 nM 0.227640990943518 0.412733786564112 no 1363 0.409962675149178 1999 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2655 perillic acid 100 µM 0.225504956017968 0.413531090169648 no 1364 0.410793235156711 1892 5702197 An apoptosis inducer.
SGTC_2076 5212012 200 µM 0.225434625215182 0.413557348165409 no 1365 0.410820588889948 1952 604802
SGTC_1602 st001878 87.6 µM 0.224272174031509 0.413991405071856 no 1366 0.411272763328652 1961 595405 YLR310C CDC25
SGTC_2717 st081029 62.2815 µM 0.223777767198866 0.414176047461314 no 1367 0.411465115244528 2034 5292846
SGTC_2502 avocadyne acetate 18.59 µM 0.223165880222494 0.414404590538014 no 1368 0.411703202972411 1994 3952079
SGTC_167 3672-0051 66.205 µM 0.22236748309375 0.414702839729716 no 1369 0.412013911441169 1890 3237971
SGTC_2271 7849410 118.62 µM 0.220749742697295 0.415307313355075 no 1370 0.412643648831153 2070 972430
SGTC_1474 0330-0125 5.35 µM 0.219716855181062 0.415693359894158 no 1371 0.41304583844125 1978 X1474
SGTC_264 promethazine 12.5 mM 0.219128677287455 0.415913230521989 no 1372 0.413274906170374 2050 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_464 bw-b 70c 158 µM 0.21896577424 0.415974131034039 no 1373 0.41333835449855 2010 5353454
SGTC_3203 9113543 49.47 µM 0.218329332198079 0.416212081124176 no 1374 0.413586260942002 1931 17018012
SGTC_1850 st056238 17 µM 0.216942940468601 0.416730525244092 no 1375 0.41412640637275 2031 5393177
SGTC_45 0kpi-0036 14.9 µM 0.216712640455066 0.416816660476283 no 1376 0.414216148220012 1934 2795021
SGTC_1740 st038286 13.222 µM 0.216616425476745 0.416852647325825 no 1377 0.414253641988738 1953 716786
SGTC_1963 st076565 50.3 µM 0.215432421230014 0.417295551986811 no 1378 0.414715097448582 1907 4914280
SGTC_2793 7325131 81.82 µM 0.213981364722466 0.417838496924978 no 1379 0.415280794705964 1937 4176441
SGTC_327 1273-0057 3.96 µM 0.21367646251711 0.417952602789733 no 1380 0.415399683808596 2017 3108138
SGTC_3296 9122258 64.045 µM 0.21331354743546 0.418088428255903 no 1381 0.415541203698944 1925 4730474
SGTC_2722 naftopidil 47.16 µM 0.213295865341856 0.418095046248262 no 1382 0.415548099167636 2007 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1798 st045719 60.953 µM 0.211698221813063 0.418693102185363 no 1383 0.416171237724404 2015 3980186
SGTC_3019 9081971 49.47 µM 0.210189382452984 0.419258088121492 no 1384 0.41675993302356 2030 16451803
SGTC_2318 6029776 164 µM 0.209426957253551 0.419543642168367 no 1385 0.417057475238578 1969 818325
SGTC_1948 st076329 66.6 µM 0.209254201964377 0.419608350766153 no 1386 0.417124900908592 2039 24208413
SGTC_882 0843-0131 351 µM 0.208696336995704 0.41981732395036 no 1387 0.417342649917507 2060 5425421
SGTC_1228 0124-0032 52.5 µM 0.208374354214962 0.419937947244849 no 1388 0.417468339600479 2005 X1228
SGTC_2128 5255449 168.493 µM 0.206870533486568 0.420501417820558 no 1389 0.418055484794137 1944 736008
SGTC_2610 ononetin 44.17 µM 0.206476694288923 0.420649013445058 no 1390 0.418209283888317 1887 259632
SGTC_230 MPP+ 141.667 µM 0.20501553263751 0.421196697357376 no 1391 0.418779994744532 1893 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1378 2093-0007 380 nM 0.204045058963851 0.42156054216484 no 1392 0.419159143788607 1928 3618014
SGTC_1615 st002656 86.5 µM 0.2030826862253 0.421921415959581 no 1393 0.419535202072761 2024 1584458
SGTC_1093 fluphenazine 7.97 µM 0.201668866647158 0.42245169366709 no 1394 0.420087801651963 1948 6602611 An atypical antipsychotic.
SGTC_1128 3448-9350 235 µM 0.201526581253371 0.422505068089071 no 1395 0.4201434234681 1884 619386
SGTC_220 paclitaxel 373.376 µM 0.201509565510741 0.422511451168599 no 1396 0.420150075322364 2035 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_34 0469-0683 81.75 µM 0.199420752832746 0.423295177115201 no 1397 0.420966814042046 2005 3690923
SGTC_2620 irigenin 100 µM 0.199014711227874 0.423447559932906 no 1398 0.421125618439027 2022 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1857 st056007 79.3 µM 0.198952756396058 0.423470811887356 no 1399 0.421149850335561 2052 619834
SGTC_959 1222-0044 107 µM 0.198925632784902 0.423480991596503 no 1400 0.421160459070092 2108 6083612
SGTC_2786 7743617 45.45 µM 0.19600759071824 0.424576453164869 no 1401 0.422302112353851 1874 583674
SGTC_3234 9132280 49.47 µM 0.195730857859777 0.42468037177933 no 1402 0.422410415230789 1960 17612295
SGTC_2852 9023854 51.95 µM 0.195525653068037 0.424757433582978 no 1403 0.42249072848954 2013 19798528
SGTC_1693 xanthone 101.9 µM 0.194103697515011 0.425291508052242 no 1404 0.423047343245764 2012 7020 An insecticide.
SGTC_1004 4084-0029 199 µM 0.193230051162665 0.425619710296509 no 1405 0.423389402393828 2076 716894 YLR208W SEC13
SGTC_368 fentichlor 4.58 µM 0.192952521169525 0.425723980634218 no 1406 0.423498075934894 1923 7329 A pesticide.
SGTC_3294 9122953 26.2835 µM 0.192664069159557 0.425832359969683 no 1407 0.423611032421804 2007 16459826
SGTC_113 0099-0221 2.5 µM 0.191571080493755 0.426243076575518 no 1408 0.424039098664344 2044 89219
SGTC_987 1497-1013 404 µM 0.188930584644321 0.427235635270261 no 1409 0.425073611078655 2041 1676435
SGTC_2337 9009472 200 µM 0.188912330186712 0.42724249870637 no 1410 0.425080764745788 2071 5742383
SGTC_3317 9138495 8.753 µM 0.187535475873931 0.427760241159294 no 1411 0.425620405670667 2100 17020139
SGTC_1158 4092-0494 91.8 µM 0.186109480476374 0.428296593421122 no 1412 0.426179453727807 2046 1148199
SGTC_2203 7227154 166.4 µM 0.185766883856227 0.428425472288531 no 1413 0.426313787652953 2064 896304
SGTC_790 1575-0012 79.1 µM 0.185548119683303 0.428507771545631 no 1414 0.426399570702095 2088 378741 YLR208W SEC13
SGTC_985 1493-0307 8.71 µM 0.184751964336426 0.428807312046394 no 1415 0.426711793022189 2099 3278274
SGTC_3075 9116269 49.47 µM 0.18407877050413 0.429060622283152 no 1416 0.426975830283677 1996 17015205 YNL244C SUI1
SGTC_387 norethindrone acetate 66.7 µM 0.181587352715898 0.429998349528932 no 1417 0.427953287451564 1955 541197
SGTC_1129 3453-1384 223 µM 0.179994691334885 0.430598007465078 no 1418 0.428578367918286 2005 1084452
SGTC_2854 9024559 71.43 µM 0.179903195008779 0.430632461909158 no 1419 0.428614283436884 1939 3163529
SGTC_3059 1327-0034 3 µM 0.178900400355837 0.431010115255186 no 1420 0.429007954209653 1956 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3084 9116877 49.47 µM 0.178852040038403 0.43102832939053 no 1421 0.429026940985055 2095 27241325
SGTC_1718 roemerine 11.9335 µM 0.176950508209879 0.431744626652231 no 1422 0.429773632365994 2089 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.174596501299735 0.432631679667205 no 1423 0.430698348958289 2025 6312947
SGTC_3120 9124077 49.47 µM 0.17295026068563 0.433252229419322 no 1424 0.431345262279343 2128 18774327 YGL155W CDC43
SGTC_1939 st074455 53.6 µM 0.172413627616752 0.433454548692109 no 1425 0.431556179658963 2115 1644229
SGTC_1816 st051957 91.6 µM 0.171621305640118 0.433753298651844 no 1426 0.431867628248301 2025 674121
SGTC_130 0136-0219 337.655 µM 0.171425006468086 0.433827320339993 no 1427 0.431944796741312 2135 234244
SGTC_503 tyrphostin 8 294 µM 0.170462604670831 0.434190262207667 no 1428 0.432323170531191 2113 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_625 k213-0058 121 µM 0.169785321348568 0.434445713208455 no 1429 0.432589485592502 2033 3655420
SGTC_2026 5148700 152 µM 0.167268088574664 0.435395377179326 no 1430 0.433579555997425 1999 79838
SGTC_204 PMA1.184 62.41 µM 0.166967201197463 0.435508916519178 no 1431 0.433697928131674 2110 2252213 YGL008C PMA1
SGTC_574 1315-0397 40 µM 0.166324271066638 0.435751542915529 no 1432 0.433950883257941 2087 6794277
SGTC_1100 amiodarone 5.07 µM 0.165994920397357 0.435875841324499 no 1433 0.434080473826005 2140 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1062 mesoridazine 14.2 µM 0.165912453771408 0.435906965588366 no 1434 0.434112923319392 2091 4078 A neuroleptic.
SGTC_1515 3460-0031 42.1 µM 0.16401814823405 0.43662201662079 no 1435 0.434858428531331 2055 2876596
SGTC_2374 9071832 200 µM 0.163897976385171 0.436667385377379 no 1436 0.434905730084686 2110 17381698
SGTC_2918 7977171 22.06 µM 0.162968268734749 0.437018408170264 no 1437 0.435271709255453 2043 2236483
SGTC_3265 9137266 49.47 µM 0.162357309660069 0.437249110456507 no 1438 0.43551224334794 2166 17224265
SGTC_2651 TUB2.036 5 µM 0.161311669167491 0.437644000860829 no 1439 0.435923966478257 2119 15992207 YFL037W TUB2
SGTC_3063 1327-0034 4 µM 0.159920812582887 0.438169359730337 no 1440 0.436471726724355 2093 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_50 0929-0078 56.389 µM 0.159680797579021 0.438260030030089 no 1441 0.436566264051552 2061 1377751
SGTC_19 0279-0214 38.434 µM 0.159586958016332 0.438295480617444 no 1442 0.436603226649057 2101 3566274 YBR002C RER2
SGTC_1421 4029-0249 71.4 µM 0.158776451560196 0.43860169326472 no 1443 0.436922501182575 2150 2894095
SGTC_2908 7930301 100 µM 0.156971353277738 0.439283798589649 no 1444 0.437633712480134 2099 2223178
SGTC_2712 st079126 47.7 µM 0.154761543704064 0.440119080348407 no 1445 0.438504654770958 2052 3152970
SGTC_259 usnic acid 108.925 µM 0.154680654755395 0.440149660489867 no 1446 0.438536540845099 2099 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_677 0929-0063 136 µM 0.153865267710741 0.440457938220304 no 1447 0.438857985141921 2142 1539583
SGTC_1838 st055369 84.5 µM 0.15281789785977 0.440853975860605 no 1448 0.439270941533691 2141 676036
SGTC_1065 prochlorperazine maleate 2.48 µM 0.152392616574583 0.441014802629087 no 1449 0.439438640092456 2134 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3297 9117502 71.43 µM 0.151357555509328 0.441406267756444 no 1450 0.439846834727166 2192 7453720
SGTC_1596 piperlongumine 63 µM 0.150933867388691 0.441566525198371 no 1451 0.440013942101598 2155 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3126 9127922 49.47 µM 0.150375811827037 0.441777620897992 no 1452 0.440234061813649 2062 45595682
SGTC_1828 st055811 49 µM 0.149771414347284 0.442006265009517 no 1453 0.440472481490236 2152 5877589
SGTC_1193 1488-0126 41.5 µM 0.148672742940587 0.442421942829069 no 1454 0.440905935075154 2099 1384710
SGTC_1301 naphtanilide LB 4.81 µM 0.148509821894343 0.442483588747281 no 1455 0.440970217578576 2139 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_244 nsc-207895 1.295 µM 0.148191109593702 0.442604186845132 no 1456 0.441095973934181 2085 42640
SGTC_770 0389-1121 67.2 µM 0.147502044596 0.442864941504855 no 1457 0.44136788301402 2136 6753108
SGTC_265 mycophenolic acid 32.932 µM 0.147110188455303 0.443013238003129 no 1458 0.441522524075483 2126 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1770 st043884 66.3 µM 0.146166366634465 0.443370456590891 no 1459 0.441895027949374 2152 670149
SGTC_1401 3807-4679 7.6 µM 0.144322234019398 0.444068558235459 no 1460 0.442623010947201 2114 3291456
SGTC_3031 9088762 49.47 µM 0.14364926452263 0.444323356095 no 1461 0.442888718294413 2144 205253
SGTC_3160 9100216 49.47 µM 0.142426249703215 0.44478646944093 no 1462 0.443371664735095 2176 17191039
SGTC_2403 6032726 181.2 µM 0.140464670195623 0.445529408791881 no 1463 0.4441464324018 2050 2881040
SGTC_1332 1480-0653 17.5 µM 0.13925035628528 0.445989420731441 no 1464 0.44462615876179 2188 5749438
SGTC_2302 7771753 200 µM 0.138354323516583 0.446328906611869 no 1465 0.44498019715892 2025 2203047
SGTC_86 0417-1630 471.922 µM 0.138300793830278 0.446349189007185 no 1466 0.445001349077072 2162 3634867
SGTC_2113 5491891 107.031 µM 0.137932793270694 0.446488628196472 no 1467 0.445146766414236 2040 789979
SGTC_231 b-estradiol 524 µM 0.137126472509333 0.446794174518141 no 1468 0.445465414039914 2039 450 A steroid.
SGTC_3307 9126885 69.2785 µM 0.136453612597881 0.447049171514354 no 1469 0.445731346626572 2016 24824909
SGTC_3210 9128157 49.47 µM 0.136411315673851 0.44706520171799 no 1470 0.44574806434137 1905 17590849
SGTC_2018 5133068 143 µM 0.136314014598983 0.447102078393168 no 1471 0.445786522625096 2106 785362
SGTC_1997 st073024 93.8 µM 0.135930105465182 0.447247582708748 no 1472 0.445938267817288 2172 686268
SGTC_2197 6588183 93.1375 µM 0.135687961487148 0.447339360666208 no 1473 0.446033982519751 2109 884136
SGTC_2830 7992007 71.43 µM 0.135269223607324 0.447498078294927 no 1474 0.446199508700496 1989 1952075
SGTC_2507 purpurin 79.67 µM 0.134184419180263 0.447909299593602 no 1475 0.446628373089163 2014 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3119 9125183 49.47 µM 0.133082177694911 0.448327188175248 no 1476 0.447064194951514 2167 22695334
SGTC_448 monastrol 171 µM 0.131095471074688 0.449080545149985 no 1477 0.447849891901669 2146 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2103 5378138 10 µM 0.129405787187257 0.449721416026533 no 1478 0.448518284336427 2159 244142
SGTC_426 0988-0037 14.6 µM 0.129347563527965 0.449743501704144 no 1479 0.448541318629157 2227 5383008
SGTC_1677 st019204 53.9 µM 0.129329834759513 0.449750226696519 no 1480 0.448548332472901 1988 3945625
SGTC_1234 0326-0494 15.5 µM 0.128888845576479 0.449917510236202 no 1481 0.448722801493735 2149 1547813
SGTC_1627 st003713 25.6 µM 0.12881853321671 0.449944183143349 no 1482 0.448750620165124 2056 16195070 YER133W GLC7
SGTC_42 0133-0086 60.653 µM 0.127602689384412 0.450405447665756 no 1483 0.449231701356394 2153 162923 Model of phenazepam hydroxylation.
SGTC_3064 1327-0027 10 µM 0.127348627057022 0.450501841832094 no 1484 0.449332237375542 2123 16000455 YPR107C YTH1
SGTC_176 1486-1328 72.834 µM 0.126720314382988 0.450740243407962 no 1485 0.449580883451435 2081 22310231
SGTC_2743 auranofin 4.32 µM 0.123942765419179 0.451794344561596 no 1486 0.450680296037015 2161 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2602 kawain 100 µM 0.123634077233623 0.451911515222981 no 1487 0.450802504871012 2216 5369129
SGTC_2556 citropten 84.59 µM 0.123293042683386 0.452040968661622 no 1488 0.450937524967361 2171 2775 A potential DNA crosslinker.
SGTC_2263 7948595 193.29 µM 0.123279713493291 0.452046028397749 no 1489 0.450942802285685 2122 2971371
SGTC_477 mead ethanolamide 10 µM 0.122976865115446 0.452160991184108 no 1490 0.451062708927166 2194 16061185
SGTC_2570 licareol 100 µM 0.122642255971025 0.452288015183058 no 1491 0.451195195789155 2051 443158
SGTC_2496 diffractaic acid 79.83 µM 0.122528304041041 0.452331274619662 no 1492 0.451240315742966 2191 94870 An apoptosis inducer which activates caspases.
SGTC_2314 7727897 200 µM 0.121655477436092 0.452662643483002 no 1493 0.451585937551033 2102 900724
SGTC_3040 9091894 49.47 µM 0.121636177140298 0.452669971219117 no 1494 0.4515935804963 2147 25236966
SGTC_1778 st046819 58.9 µM 0.121401888539893 0.452758924769534 no 1495 0.451686360553641 2142 671715
SGTC_289 k017-0060 526 µM 0.121326140418157 0.452787684953479 no 1496 0.451716357947397 2143 5512909
SGTC_2464 5717415 7.67 µM 0.120940780218784 0.452934003043458 no 1497 0.451868970638741 2114 5285744
SGTC_756 0508-1999 28.3 µM 0.120435389790192 0.453125905305145 no 1498 0.452069129209433 2000 6753853
SGTC_694 1315-0438 43.2 µM 0.119825250871116 0.453357596293893 no 1499 0.45231078937676 2137 6793154
SGTC_360 0957-0399 1.01 µM 0.118965667791307 0.453684036837814 no 1500 0.452651277852318 2179 6752301 YPR165W RHO1
SGTC_2787 5284540 71.43 µM 0.117969901428996 0.45406223429139 no 1501 0.453045753248852 2092 736958
SGTC_633 0437-0093 97.7 µM 0.117649526542501 0.454183923280913 no 1502 0.453172680453277 2170 2831118
SGTC_355 1311-2252 105 µM 0.117621956747167 0.454194395403157 no 1503 0.453183603371645 2052 5338538
SGTC_471 1-acyl-paf 4 µM 0.117116535283094 0.454386380532313 no 1504 0.45338385332437 2123 16759367
SGTC_879 0831-1030 162 µM 0.116762227930204 0.454520971087843 no 1505 0.45352423834807 2157 1549252
SGTC_860 0443-0016 25.1 µM 0.116245039712448 0.454717444485483 no 1506 0.453729171076906 2216 5337942
SGTC_657 3534-0529 86.7 µM 0.116230339151104 0.454723029208796 no 1507 0.453734996266494 2203 1049549
SGTC_2626 ethyl orsellinate 100 µM 0.116218731896482 0.454727438795405 no 1508 0.453739595720935 2127 75653 A natural product.
SGTC_2874 9043904 71.43 µM 0.116026008761035 0.454800654973041 no 1509 0.45381596449456 2063 4463428
SGTC_2536 dehydroabietamide 32.04 µM 0.11595687658524 0.454826918897165 no 1510 0.453843359335879 2180 3983547
SGTC_3312 9133330 71.43 µM 0.114186969211921 0.455499389266389 no 1511 0.454544790702707 2177 17617324
SGTC_897 1000-0139 31.4 µM 0.113904672690624 0.455606658724155 no 1512 0.454656680703326 2211 6151020
SGTC_1334 1486-0610 236 µM 0.113547814736995 0.455742265306171 no 1513 0.454798128743997 2146 3742339
SGTC_237 nikkomycin 200 µM 0.113103886950074 0.455910965756286 no 1514 0.454974096714304 2189 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_572 0960-0087 17.7 µM 0.11305033231091 0.455931318009053 no 1515 0.45499532576747 2156 6796365
SGTC_1678 st019265 80.2 µM 0.112663483788668 0.45607833464073 no 1516 0.455148676293499 2222 5367020
SGTC_984 1492-0255 2.91 µM 0.111001044016869 0.456710190947412 no 1517 0.45580775942193 2136 1585198
SGTC_338 4055-0136 114 µM 0.110277087670424 0.456985384929479 no 1518 0.45609481390648 2189 2900563
SGTC_2276 7947513 42.08 µM 0.110257199128867 0.456992945355171 no 1519 0.45610270019649 1952 2105100
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.106845325116543 0.458290162476345 no 1520 0.457455844507187 2122 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2145 5634607 200 µM 0.106011288224202 0.458607336952507 no 1521 0.457786697975258 2121 308662
SGTC_749 1000-0129 128 µM 0.104991346447464 0.458995244683247 no 1522 0.458191337651567 2216 708470
SGTC_1444 4112-3581 28 µM 0.10442974413371 0.459208851880785 no 1523 0.458414159658439 2167 2877249
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.104383367333002 0.459226491969334 no 1524 0.458432560758555 2130 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_229 benomyl 22.8748 µM 0.103930556385757 0.459398729391337 no 1525 0.458612228960143 2133 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1952 st077036 64.1 µM 0.102324065336934 0.460009857761372 no 1526 0.459249727091595 2237 2937007
SGTC_1557 sumaresinolic acid 42.3 µM 0.102289982440193 0.460022824330773 no 1527 0.459263253227405 2176 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_263 alizarin 107.927 µM 0.10188817556171 0.460175691791832 no 1528 0.459422717825412 2228 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1347 1493-0251 600 nM 0.101137564850647 0.46046127745314 no 1529 0.459720629237892 2223 3986378
SGTC_1667 st014849 34.6 µM 0.100856228827721 0.46056832293413 no 1530 0.459832295100543 2221 5348460
SGTC_1809 st050081 57.6 µM 0.100554189864851 0.460683248852771 no 1531 0.459952181751211 2194 5036894
SGTC_1951 sophoraflavanone G 9.2 µM 0.10040227128825 0.460741055160035 no 1532 0.460012483326373 2111 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_521 r062-0005 13.8 µM 0.0981807839539458 0.461586444073891 no 1533 0.460894370459121 2108 2832033
SGTC_454 lyso-paf C-16 6.67 µM 0.0955544840405664 0.462586108403736 no 1534 0.461937208092711 2133 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3011 9081274 71.4286 µM 0.0953768632317348 0.462653725884145 no 1535 0.462007746377467 2139 6625322
SGTC_1562 morin hydrate 59.1 µM 0.0953426178806424 0.462666762681037 no 1536 0.462021346319734 2151 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_900 1112-0045 141 µM 0.0951711796190078 0.46273202778598 no 1537 0.462089430694305 2234 56211 YIL048W NEO1
SGTC_1027 k015-0025 8.67 µM 0.0946937566375074 0.462913783983148 no 1538 0.462279038587979 2249 3598955
SGTC_536 3852-0578 10.6 µM 0.0942290276920383 0.463090714964138 no 1539 0.462463613296034 2219 2869208
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0940109899381834 0.463173728524076 no 1540 0.462550213347288 2215 6708561
SGTC_1695 st026914 34.495 µM 0.0936299534567244 0.463318804471844 no 1541 0.462701557355048 2163 3289191
SGTC_2760 etidronate 98.04 µM 0.0933770867467482 0.463415083715363 no 1542 0.462801996550285 2194 3305 A chelator and antioxidant.
SGTC_2357 9067248 200 µM 0.0928611091091455 0.46361154933955 no 1543 0.463006951315881 2152 9150235
SGTC_3270 9137563 49.47 µM 0.0925038019643064 0.463747604181882 no 1544 0.463148885322055 2221 17015724
SGTC_3274 9138298 49.47 µM 0.0911186334268589 0.464275086374043 no 1545 0.46369916344945 2248 17015756
SGTC_373 0844-0104 25.9 µM 0.0897184045207239 0.46480836748599 no 1546 0.464255495115515 2271 5375804
SGTC_1295 1013-0063 9.78 µM 0.0895966599700198 0.464854737241036 no 1547 0.464303869345448 2270 6826038
SGTC_1912 st060209 90.8 µM 0.0895761013816462 0.464862567591045 no 1548 0.464312038189291 2137 688787
SGTC_780 0109-0199 192 µM 0.089153650809856 0.465023473467603 no 1549 0.464479899963636 2258 610414
SGTC_2962 9082311 13.18 µM 0.0891436832613778 0.465027270045125 no 1550 0.464483860670017 2169 16459453
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0889201198625422 0.465112424795861 no 1551 0.464572696775665 2252 6708630 An antioxidant.
SGTC_207 4185-0010 4.486 µM 0.0862256650958402 0.466138860556517 no 1552 0.465643514443133 2256 3761753
SGTC_833 3852-0053 558 µM 0.0850195048320157 0.466598413197553 no 1553 0.466122942118877 2212 3123681
SGTC_691 1548-0686 185 µM 0.0849979826850419 0.466606613641352 no 1554 0.466131497245602 2182 46495133
SGTC_1252 0493-0875 34.8 µM 0.0839359540837621 0.467011289037266 no 1555 0.466553676593481 2216 3960963
SGTC_2837 9008476 45.46 µM 0.0836290683254812 0.467128231160915 no 1556 0.466675677352207 2187 2992805
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0834317436346042 0.467203425359154 no 1557 0.466754124361018 2247 16486 A toxic proline analog.
SGTC_2341 7987486 176.74 µM 0.081711875670231 0.46785886190724 no 1558 0.467437917261344 2247 1258686
SGTC_2066 5222451 176 µM 0.0781811731756233 0.469204673224285 no 1559 0.46884196890118 2260 2281147
SGTC_3004 9076122 71.4286 µM 0.0781326859164628 0.469223157782419 no 1560 0.468861253528751 2254 44782551
SGTC_2315 7733312 200 µM 0.0774436899599771 0.469485827454866 no 1561 0.469135292779865 2213 726316
SGTC_3315 9136395 68.55 µM 0.0765704496787954 0.469818756660396 no 1562 0.469482633828012 2263 16876844
SGTC_2749 bexarotene 57.39 µM 0.0762197716692339 0.46995246115237 no 1563 0.469622126463267 2182 82146 An retinoic acid receptor inhibitor.
SGTC_636 0kpi-0074 126 µM 0.0760648834026205 0.470011517138237 no 1564 0.469683739078062 2191 616434
SGTC_2940 9060638 45.86 µM 0.0749143794367376 0.470450203244364 no 1565 0.470141417785729 2172 4027022
SGTC_349 k015-0014 24 µM 0.0745616828082694 0.470584693352199 no 1566 0.470281730955729 2232 2196908
SGTC_1107 amlodipine 47 µM 0.0744882928018069 0.470612678816205 no 1567 0.470310928139379 2226 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3166 9102297 49.47 µM 0.073729979254229 0.470901851406719 no 1568 0.470612621853842 2196 25237072
SGTC_730 1436-0052 41.2 µM 0.0733975404292565 0.471028627292206 no 1569 0.470744887385694 2290 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1925 st057770 10.1 µM 0.0733891650443272 0.471031821291775 no 1570 0.470748219693881 2122 5989122
SGTC_999 SEC7.066 22.7 µM 0.0726109086566528 0.471328621792312 no 1571 0.471057872892163 2218 740511 YDR170C SEC7
SGTC_104 0074-0074 590.992 µM 0.0720527033262094 0.471541512125366 no 1572 0.471279982808772 2290 3943124
SGTC_2921 7974240 10.71 µM 0.0720490093850854 0.471542920960913 no 1573 0.471281452657879 2233 2979074 YDR527W RBA50
SGTC_2098 5376439 882.5 nM 0.071256062399332 0.471845351942898 no 1574 0.471596981711224 2237 2844116
SGTC_2286 7945697 125 µM 0.0689567837378645 0.47272239089623 no 1575 0.472512009577354 2209 1245733
SGTC_1805 st050013 60.3 µM 0.0686003225859527 0.472858371712734 no 1576 0.472653881043537 2245 4037144
SGTC_1121 fusaric acid 630.51 nM 0.068509074534526 0.472893181020718 no 1577 0.472690198307922 2156 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3153 9100258 49.47 µM 0.0671990797711713 0.473392940530991 no 1578 0.473211608853331 2231 25236848
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0646587381583119 0.4743621927415 no 1579 0.474222858109461 2254 2724278 An inhibitor of dopamine biosynthesis.
SGTC_306 1672-3436 11.6 µM 0.0619733034671125 0.4753869692588 no 1580 0.47529204593563 2235 6797378
SGTC_741 4582-0002 126 µM 0.0615928839127114 0.475532152759369 no 1581 0.475443521999718 2261 2912688
SGTC_2745 rifampicin 24.3 µM 0.0608731022454544 0.475806859451729 no 1582 0.475730135503561 2296 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1012 4112-3522 18 µM 0.0606519086011332 0.475891280942605 no 1583 0.47581821624941 2301 3112398
SGTC_2569 tetrandrine 100 µM 0.0589582482131444 0.476537724504629 no 1584 0.476492681664717 2183 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_670 4204-0025 119 µM 0.0586912132545354 0.476639653232345 no 1585 0.476599029040953 2270 719039
SGTC_1873 rapamycin 2 nM 0.0582395591776264 0.476812055578857 no 1586 0.476778905257394 2271 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2473 5854593 8.94 µM 0.0563612298812272 0.477529084958114 no 1587 0.477527020954477 2265 2872951
SGTC_488 nitrendipine 139 µM 0.0555059079468741 0.477855617956823 no 1588 0.477867711673646 2318 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_499 genistein 192 µM 0.0536602772225393 0.478560267734946 no 1589 0.47860291568146 2316 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_165 k038-0023 64.381 µM 0.052203166448686 0.479116630582632 no 1590 0.479183404957334 2313 46368543
SGTC_364 0083-0097 67.7 µM 0.0518717474314121 0.479243180715424 no 1591 0.479315443121302 2244 5207356
SGTC_881 0833-0569 170 µM 0.051490410924886 0.479388794095421 no 1592 0.479467371345231 2241 5418700
SGTC_888 0916-0002 6.97 µM 0.051329690483237 0.479450166035947 no 1593 0.479531404848663 2306 2802138 YIL048W NEO1
SGTC_2819 7996655 46.38 µM 0.0511985108019156 0.479500258043936 no 1594 0.479583669249063 2301 6456960
SGTC_281 1672-3440 14.9 µM 0.0510146614073442 0.479570462946859 no 1595 0.479656918823526 2295 6833000
SGTC_188 3229-0966 278.469 µM 0.0506707513503422 0.479701790464979 no 1596 0.479793941869774 2319 5722370
SGTC_1446 4239-0190 62 µM 0.0504684596705062 0.479779039786391 no 1597 0.479874541449733 2253 1340085
SGTC_1701 st028638 40.4 µM 0.0498861144825738 0.480001424742279 no 1598 0.480106571282046 2316 3490878
SGTC_2667 digitoxin 100 µM 0.0495209773352977 0.480140865853267 no 1599 0.480252060105511 2325 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_490 phenamil 164 µM 0.0490472109984902 0.480321794653731 no 1600 0.480440836126151 2317 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2023 5144124 124 µM 0.0489981112883086 0.480340545799855 no 1601 0.480460400553542 2292 2830192
SGTC_938 3126-1755 342 µM 0.0477291801809702 0.480825164702806 no 1602 0.480966039088413 2316 1777771
SGTC_148 3253-0744 288.01 µM 0.0476644384512288 0.480849891055379 no 1603 0.480991837939005 2337 6893655
SGTC_2275 7947463 200 µM 0.0467352726036946 0.481204768889393 no 1604 0.481362108788405 2330 1225414
SGTC_1621 st003705 32.4 µM 0.0465920460888017 0.481259472958831 no 1605 0.481419185724549 2319 24207032
SGTC_2957 9076800 11.52 µM 0.0465877833365273 0.481261101083846 no 1606 0.481420884471994 2282 16459615
SGTC_2303 7774051 200 µM 0.0454643259597385 0.481690207688409 no 1607 0.481868604620397 2309 2953184
SGTC_1219 1469-0211 33.1 µM 0.0435256511442713 0.482430737695415 no 1608 0.482641258620925 2330 6822282
SGTC_324 1315-0088 19.6 µM 0.0424519177037879 0.482840905874371 no 1609 0.4830692206404 2324 6787421
SGTC_1168 k815-0004 80.5 µM 0.041612180867245 0.483161699591661 no 1610 0.483403931362882 2320 642433
SGTC_2696 st077691 74.316 µM 0.0416041698009505 0.483164760007712 no 1611 0.483407124550654 2292 757133
SGTC_3267 9137951 49.47 µM 0.041401619732199 0.483242139234806 no 1612 0.483487860773209 2291 16643986
SGTC_2220 6782180 200 µM 0.040524940931577 0.483577059855014 no 1613 0.48383731169127 2326 833803
SGTC_1013 4112-3890 241 µM 0.040215496965291 0.483695280577963 no 1614 0.48396066141649 2273 705171
SGTC_1460 k062-0059 9.15 µM 0.039613266737036 0.483925362174132 no 1615 0.484200725207507 2303 1373085
SGTC_2810 7959871 45.46 µM 0.0389427513836769 0.484181538343888 no 1616 0.48446801586414 2299 2974535
SGTC_658 3253-0951 102 µM 0.0358287172729523 0.485371365814136 no 1617 0.485709467344934 2300 1184878
SGTC_2650 prasterone 100 µM 0.0349504926706634 0.485706946759043 no 1618 0.486059608927679 2333 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_925 2064-1272 59.6 µM 0.0344594279882913 0.485894593333903 no 1619 0.486255397447211 2287 6815817
SGTC_559 1550-0661 158 µM 0.0341463834884731 0.486014216129184 no 1620 0.486380210678521 2302 5830875
SGTC_1822 st052468 42 µM 0.0335212650254881 0.486253094606436 no 1621 0.486629454160821 2330 2873678
SGTC_2646 retinol 96.75 µM 0.0331991909730505 0.486376171704254 no 1622 0.486757871639103 2328 445354 A vitamin A analog and teratogen.
SGTC_1505 k297-0037 20.6 µM 0.0325676445068393 0.486617514076949 no 1623 0.487009686039651 2323 4089396
SGTC_2349 9023730 187.07 µM 0.0309983618415509 0.487217228752952 no 1624 0.487635423053704 2330 4126287
SGTC_98 0074-0023 107.663 µM 0.0308898338174154 0.487258704741821 no 1625 0.487678698747116 2276 3563821
SGTC_1744 st037937 38.9 µM 0.0299847585219142 0.487604601306357 no 1626 0.488039604321705 2323 1016152
SGTC_1256 0570-0116 285 µM 0.0284690142392261 0.488183900648318 no 1627 0.488644040531375 2326 410638
SGTC_1400 3771-8998 51.5 µM 0.0280717438129049 0.488335736828421 no 1628 0.488802465179871 2326 670767
SGTC_509 pifithrin 175 µM 0.0272962645444104 0.488632128729677 no 1629 0.489111718110838 2364 4817 A p53 inhibitor.
SGTC_1888 azatryptophan 97.5 µM 0.0253801539594564 0.48936450197612 no 1630 0.489875870427557 2265 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_609 0986-0026 86.3 µM 0.0251819737221268 0.489440252252048 no 1631 0.489954907641588 2357 2848610
SGTC_1721 st082152 9.2685 µM 0.0246664438108244 0.48963730462108 no 1632 0.490160510445929 2374 5296051
SGTC_173 1273-0061 2.693 µM 0.0242439214143896 0.489798808368572 no 1633 0.490329022095797 2332 2847414 YPL266W DIM1
SGTC_1172 0370-0043 85 µM 0.0241631966891755 0.489829664546844 no 1634 0.490361217170234 2331 376585
SGTC_2132 5317594 122.667 µM 0.0231844329791423 0.490203791482553 no 1635 0.490751577977022 2351 794577
SGTC_3066 9117245 49.47 µM 0.0222810998608705 0.490549093153646 no 1636 0.4911118626332 2350 17176980
SGTC_1192 1488-0095 21.4 µM 0.021319460246174 0.490916690427449 no 1637 0.4914954101675 2333 915875
SGTC_1175 0741-0056 27.6 µM 0.0204199373425093 0.491260549897736 no 1638 0.491854189733158 2358 765927
SGTC_398 bronopol 33.3 µM 0.0184174445119103 0.492026063220076 no 1639 0.492652918047403 2349 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2557 derrustone 83.84 µM 0.0181842650940673 0.492115205053218 no 1640 0.492745927599146 2283 629853 An antioxidant.
SGTC_2308 7584454 197.62 µM 0.0177642710138871 0.49227576499241 no 1641 0.492913453930104 2369 893577
SGTC_1926 methyl fluorone black 53.6 µM 0.017758035659288 0.492278148721584 no 1642 0.492915941084359 2373 72721 Reacts with homocysteine.
SGTC_1747 st037496 66.6 µM 0.0177552564861754 0.492279211178655 no 1643 0.492917049639241 2371 723305
SGTC_2721 ifenprodil 61.44 µM 0.0170922554465063 0.492532673059736 no 1644 0.493181508634833 2362 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1881 5652484 16 µM 0.0168712454882011 0.492617164703025 no 1645 0.493269666139071 2370 2255129
SGTC_777 1315-0167 517 µM 0.0161609629895153 0.49288870643569 no 1646 0.493552989207562 2296 4221767
SGTC_2054 5233173 129 µM 0.0152127446218759 0.493251216410914 no 1647 0.493931227050546 2360 6889
SGTC_2168 5727979 200 µM 0.0141563935598121 0.49365507275991 no 1648 0.494352604697896 2376 695210
SGTC_753 1322-0200 289 µM 0.0138953389103848 0.493754878266765 no 1649 0.494456740191225 2362 5403907
SGTC_1661 st013063 9.66 µM 0.0137153778444121 0.493823680584467 no 1650 0.494528527427954 2385 721395
SGTC_2188 6126565 140.678 µM 0.0137131939831046 0.493824515514636 no 1651 0.494529398580637 2374 874518
SGTC_2412 st077135 33.4 µM 0.0134210137277583 0.493936221619227 no 1652 0.494645950910406 2355 13258915
SGTC_1433 4060-0023 7.6 µM 0.0116459226684408 0.494614882811449 no 1653 0.495354054073194 2381 3840627
SGTC_2185 6113692 200 µM 0.0113895167188364 0.494712914478934 no 1654 0.495456338462518 2376 874150
SGTC_3204 9114183 49.47 µM 0.0112198342785438 0.494777789329536 no 1655 0.495524027636781 2388 17027248
SGTC_1156 4092-0367 4.88 µM 0.0111434093947596 0.494807008974075 no 1656 0.495554514848243 2376 1357585
SGTC_2909 7941780 10.49 µM 0.010299177611084 0.495129787242247 no 1657 0.495891295234851 2388 1243215
SGTC_844 0330-0132 15.3 µM 0.00978953728790051 0.495324641473588 no 1658 0.496094602049385 2386 2828079
SGTC_190 3970-0790 3.722 µM 0.00967029871508523 0.49537023092625 no 1659 0.496142169105836 2392 2832352
SGTC_315 k915-0449 187 µM 0.00839123763734031 0.495859268425404 no 1660 0.49665241980707 2382 20970215 YNL149C PGA2
SGTC_579 4491-1009 110 µM 0.0082000905947305 0.495932352330313 no 1661 0.496728673820153 2396 1271041
SGTC_1567 st069303 68.4 µM 0.00819346752794045 0.495934884621932 no 1662 0.496731315952761 2379 5581319
SGTC_2043 5101342 149 µM 0.00752128312763206 0.496191891308063 no 1663 0.496999470447387 2379 678451
SGTC_3139 9095020 49.47 µM 0.00614638797370568 0.496717581101342 no 1664 0.497547961404435 2391 25236292
SGTC_2917 7979103 53.79 µM 0.00552488757815532 0.496955213084122 no 1665 0.497795899963747 2382 2980565
SGTC_576 1073-0113 22.7 µM 0.00464789475215324 0.497290534952958 no 1666 0.498145764944663 2395 5439563
SGTC_3146 9095609 49.47 µM 0.00404706199414819 0.497520266986053 no 1667 0.498385460266476 2394 17173999
SGTC_399 oxolinic acid 75 µM 0.00322308805381699 0.49783531971942 no 1668 0.498714176128129 2401 4628 A DNA gyrase inhibitor.
SGTC_1629 st005085 44.9 µM 0.00218473363452726 0.498232344365697 no 1669 0.499128418075124 2401 24207091
SGTC_1573 oleylamine 1.06 µM 0.00210004337761585 0.498264726570042 no 1670 0.499162204521797 2394 5356789 An amine of the fatty acid oleic acid.
SGTC_1630 st005209 31.3 µM 0.00183939290473577 0.498364389071736 no 1671 0.499266188813823 2400 3367314
SGTC_2352 9027995 87.8 µM 0.00169861688435501 0.498418216334674 no 1672 0.499322350232497 2379 2997347
SGTC_1398 3558-0053 112 µM 0.00116660707408937 0.498621636400954 no 1673 0.499534591219098 2402 4532369
SGTC_1959 st077091 55.8 µM 0.000824890368550756 0.498752295903614 no 1674 0.49967091639261 2401 821356 YKL052C ASK1
SGTC_472 calcifediol 10 µM 0.000526200017746746 0.498866503870848 no 1675 0.49979007657466 2403 5283731 A vitamin D metabolite.
SGTC_1041 0206-0046 107 µM 3.30947513197452e-05 0.499055048995747 no 1676 0.499986797104442 2402 50494
SGTC_1924 st058459 75.1 µM -0.000377217442120701 0.49921193728968 no 1677 0.499849512017002 2406 688683
SGTC_2445 5742597 35.57 µM -0.000864542779162581 0.499398272734007 no 1678 0.499655097375142 2409 1774255
SGTC_1296 1068-0102 11.9 µM -0.00401194833522598 0.499398272734007 no 1679 0.498399468475914 2418 767053
SGTC_774 k060-0086 136 µM -0.0043093491363495 0.499284557490657 no 1680 0.498280823749491 2415 5911235
SGTC_2638 epoxomicin 18 µM -0.00503771111484761 0.499006058640962 no 1681 0.497990252540583 2416 9915668 A protesome inhibitor.
SGTC_1767 st044992 70.3 µM -0.00516657888140018 0.498956784390112 no 1682 0.497938842409116 2422 9600693
SGTC_1253 0550-0034 176 µM -0.00533175667739414 0.498893626555068 no 1683 0.497872946910426 2420 5969915
SGTC_406 estrone 100 µM -0.00558348245432296 0.498797376050554 no 1684 0.497772524350792 2414 5870 A steroid.
SGTC_2239 6685329 187.64 µM -0.0074747838256513 0.498074215904219 no 1685 0.497018020463502 2473 805680
SGTC_2630 antimycin a 100 µM -0.00773678063146556 0.497974038952362 no 1686 0.496913501883766 2417 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_620 0109-0052 432 µM -0.00786364994020093 0.497925529320085 no 1687 0.496862889892186 2421 493037
SGTC_1735 st034310 56.75 µM -0.0078683973114914 0.497923714120153 no 1688 0.496860996023649 2508 871153
SGTC_1424 4048-1941 275 µM -0.00858685727854262 0.49764900503416 no 1689 0.496574381673359 2428 X1424
SGTC_3091 9116372 49.47 µM -0.00875684069494394 0.497584010633058 no 1690 0.496506570651446 2489 17169793
SGTC_3015 9080845 49.47 µM -0.00923602002114195 0.497400793267774 no 1691 0.496315413496042 2433 5296973
SGTC_421 streptovitacin 30 mM -0.00942208041680779 0.497329651998054 no 1692 0.496241189367586 2511 91467 include heat shock
SGTC_1981 st071826 47 µM -0.00963994033339931 0.497246352105457 no 1693 0.496154279783355 2452 11838600
SGTC_2523 spermine 47.74 µM -0.00967264260584499 0.497233848228715 no 1694 0.496141234072443 2421 1103 A DNA binding polyamine.
SGTC_2192 5915882 198.485 µM -0.009841102798106 0.49716943667852 no 1695 0.496074031378074 2426 2876149
SGTC_746 1095-0025 46.6 µM -0.0102219896743115 0.497023803056998 no 1696 0.495922087145436 2424 6749286
SGTC_1350 1495-0454 146 µM -0.0107816220656871 0.496809826097369 no 1697 0.495698838437105 2436 1069057
SGTC_1953 st076800 12.1 µM -0.011055791792775 0.496704996891247 no 1698 0.495589467061028 2438 297591
SGTC_3249 9135183 49.47 µM -0.011104979006349 0.496686190110268 no 1699 0.495569845406441 2467 4902779
SGTC_2796 7949634 45.45 µM -0.0114239214634262 0.496564242319 no 1700 0.495442613848162 2422 2971588
SGTC_522 1273-0010 11.6 µM -0.0115902862321173 0.496500632801889 no 1701 0.495376248302029 2522 5705015
SGTC_1305 1181-0477 144 µM -0.0122558173950053 0.496246168076605 no 1702 0.495110758658691 2435 6252086
SGTC_1326 1431-2094 10.8 µM -0.0124101822669399 0.496187147140823 no 1703 0.495049180668002 2419 616278
SGTC_3175 9106517 49.47 µM -0.0127024894260983 0.496075384623906 no 1704 0.49493257617615 2435 41468073
SGTC_1940 st075990 51.1 µM -0.0135327154086121 0.495757952625114 no 1705 0.494601392433815 2552 1084979
SGTC_3106 9121286 49.47 µM -0.0148861458850715 0.495240482328223 no 1706 0.494061506340764 2519 15943471
SGTC_2948 9070189 9.45 µM -0.0155934289225798 0.494970063025401 no 1707 0.493779374003449 2441 6473636 YDL196W YDL196W
SGTC_90 0870-0863 4.608 µM -0.0157750889047634 0.494900608361873 no 1708 0.493706911069342 2432 1738164
SGTC_1519 esterone 74 µM -0.0171318119967085 0.494381892953884 no 1709 0.4931657301648 2434 698 A steroid.
SGTC_2974 9094440 9.66 µM -0.0173584806978959 0.494295231700536 no 1710 0.493075315881827 2579 25236134
SGTC_1743 st037606 46.3785 µM -0.0174860306432801 0.494246466205782 no 1711 0.493024438537898 2457 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_958 1222-0007 33 µM -0.0177238658062124 0.49415553617838 no 1712 0.492929570738389 2445 7312461
SGTC_469 w7 172 µM -0.0177469843050104 0.494146697443729 no 1713 0.492920349242162 2439 45115570 A P450 inhibitor.
SGTC_2175 5807670 165.306 µM -0.0180615625859322 0.494026427207661 no 1714 0.492794870779412 2437 241186
SGTC_602 3130-1533 38.1 µM -0.0184471781220652 0.493878998599286 no 1715 0.492641058068049 2453 720941
SGTC_2929 9013348 24.6 µM -0.0188438358772729 0.493727349200024 no 1716 0.492482842024369 2459 2995952
SGTC_1597 7-benzyloxygramine 47.5 µM -0.019721080435704 0.493391966066642 no 1717 0.492132937146648 2442 260807
SGTC_624 k048-0052 28 µM -0.020092754478451 0.493249871162676 no 1718 0.491984690034313 2457 6835531
SGTC_887 0885-0007 9.62 µM -0.0205068610058631 0.493091554882156 no 1719 0.491819519468549 2514 5719458
SGTC_705 1124-0212 310 µM -0.0209870767926101 0.492907965860445 no 1720 0.491627982316087 2444 9554485
SGTC_899 1083-0020 478 µM -0.0212340265680147 0.492813556244529 no 1721 0.491529485560043 2457 767123
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0212635622731912 0.49280226468556 no 1722 0.491517705178255 2446 803109
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0213847308279404 0.492755941765988 no 1723 0.491469376907886 2468 71034 A hepatoprotective.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0217704069107596 0.492608497876474 no 1724 0.491315550227227 2465 115019
SGTC_1233 0325-0408 14.2 µM -0.0231342183945893 0.492087121254248 no 1725 0.490771605326293 2458 12874
SGTC_2623 humulene 100 µM -0.0236024830140936 0.491908109684069 no 1726 0.490584845772636 2472 6187145 An anti-inflammatory.
SGTC_1729 st035615 45.989 µM -0.0241153699374942 0.491712041449642 no 1727 0.490380291725383 2534 17385451
SGTC_3309 9129340 25.759 µM -0.0267322639210602 0.490711678106446 no 1728 0.489336639717137 2482 17158987
SGTC_1527 coumarin 137 µM -0.0283588284621871 0.490089918281765 no 1729 0.488687980555423 2571 323 A hepatotoxic, DNA x-linker.
SGTC_2947 9072639 7.68 µM -0.0289093701816713 0.489879477217307 no 1730 0.4884684362111 2474 16488146
SGTC_2686 alizarin 95.37 µM -0.02984673576496 0.489521181708984 no 1731 0.48809464280116 2485 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2141 5621638 7.665 µM -0.0301857106820298 0.48939161512886 no 1732 0.487959472281649 2506 2856238
SGTC_69 0096-0274 206.684 µM -0.0305316946415105 0.489259370632908 no 1733 0.487821508244545 2669 6741392
SGTC_1109 tnp00067 928.257 nM -0.0310543111739052 0.489059614598653 no 1734 0.487613113240143 2469 676295
SGTC_2875 9039966 71.43 µM -0.0316419865924133 0.488834994845269 no 1735 0.48737877984068 2544 6463691
SGTC_2363 9053361 176 µM -0.0317490483754358 0.488794074351285 no 1736 0.487336089817547 2477 6469797 YMR079W SEC14
SGTC_835 0312-0010 67.2 µM -0.0320095657129629 0.488694501515904 no 1737 0.48723221123593 2457 1626196
SGTC_2490 carminic acid 95.39 µM -0.034307248845601 0.487816330816705 no 1738 0.486316072265456 2463 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_808 0711-0032 135 µM -0.0344999842049435 0.487742670306781 no 1739 0.486239227472352 2449 4252555
SGTC_1289 0976-0073 69.1 µM -0.035210547332814 0.48747110756642 no 1740 0.485955925946017 2539 3391136
SGTC_1479 0549-0158 134 µM -0.0377036683474856 0.486518334325132 no 1741 0.484961975579897 2477 5440202
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.039061807720866 0.485999338659917 no 1742 0.484420555369171 2519 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_323 4013-0906 34.3 µM -0.0393175794751224 0.485901601368192 no 1743 0.484318595529211 2536 2910086
SGTC_2588 indole-3-carbinol 100 µM -0.039686867351269 0.485760487997616 no 1744 0.484171385882284 2515 3712 Induces cell cycle arrest.
SGTC_2095 5432005 200 µM -0.0401553132323144 0.485581486646066 no 1745 0.483984651873645 2494 783734
SGTC_2298 7976326 193.81 µM -0.0408468969022759 0.485317225769875 no 1746 0.483708976106424 2511 2235818
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0414188937438245 0.485098665056044 no 1747 0.483480975345749 2525 6708739 YPR165W RHO1
SGTC_1673 st016611 27.3 µM -0.0417771783817419 0.484961766320505 no 1748 0.48333816406957 2593 5226799
SGTC_544 k015-0020 52.4 µM -0.0419920473335905 0.484879666837455 no 1749 0.48325251891759 2516 3008304
SGTC_519 k048-0011 62.8 µM -0.0420862781854752 0.484843662283231 no 1750 0.483214959450594 2569 6836379
SGTC_701 4424-0219 185 µM -0.0439789655840312 0.484120514165874 no 1751 0.482460585337144 2492 2911779
SGTC_512 prima-1 270 µM -0.0447936759829206 0.483809249811599 no 1752 0.482135882934791 2567 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2926 9010726 65.15 µM -0.0468095533398025 0.483039116171089 no 1753 0.481332507458676 2545 2994293
SGTC_287 k060-0039 29.6 µM -0.0469819812545643 0.482973245746428 no 1754 0.481263794272264 2516 5861974
SGTC_196 k015-0023 18.111 µM -0.0483474010062887 0.482451648509854 no 1755 0.480719689078709 2487 5211998
SGTC_2513 baicalein 25.65 µM -0.0483669773583858 0.482444170460813 no 1756 0.480711888370154 2516 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_589 1227-0070 34.1 µM -0.0497697269973344 0.481908344754155 no 1757 0.480152945565505 2554 2841384
SGTC_359 0081-0058 15.9 µM -0.0500188483376506 0.481813188170336 no 1758 0.480053684159739 2567 3494159
SGTC_1059 3448-6867 171 µM -0.0506869498364174 0.481557999361115 no 1759 0.479787487902134 2480 3934407
SGTC_2727 riluzole 51.77 µM -0.0514128004769882 0.481280761191757 no 1760 0.479498292478932 2506 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1700 st030840 7.9285 µM -0.0518661842476936 0.481107596147065 no 1761 0.479317659526997 2571 5499307
SGTC_695 3505-6186 243 µM -0.0523157653953121 0.480935886993208 no 1762 0.479138545775038 2552 1819379
SGTC_1711 st032263 62.8 µM -0.0534858676886828 0.480489004856589 no 1763 0.478672395241216 2534 3958979
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0536942085697812 0.480409438455893 no 1764 0.478589398519586 2494 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1238 0333-0287 48.8 µM -0.0540171073749896 0.480286123367522 no 1765 0.478460767212957 2510 7226
SGTC_332 4112-0506 40.9 µM -0.0543262485704797 0.480168064079385 no 1766 0.478337618546815 2504 2790355
SGTC_2534 helenine 20.12 µM -0.0556755894943056 0.479652778854521 no 1767 0.477800123046606 2515 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1214 0358-0031 63.7 µM -0.0582943177321968 0.478652838823032 no 1768 0.476757096806443 2664 4301366
SGTC_1267 0828-0272 9.49 µM -0.0590340573994263 0.478370399324852 no 1769 0.476462490761232 2539 745334
SGTC_545 4218-0007 221 µM -0.0599483940722195 0.478021312088626 no 1770 0.476098368139528 2576 2840508
SGTC_1165 k072-0275 30.3 µM -0.0607740127334679 0.477706111237728 no 1771 0.475769593444447 2516 6153523 YGL055W OLE1
SGTC_2173 5763948 167 µM -0.0610964991167037 0.477582997663313 no 1772 0.475641178622208 2521 2867177
SGTC_1617 st002906 78 µM -0.0618165994494511 0.477308097280956 no 1773 0.475354442159678 2525 5150859
SGTC_794 k038-0031 316 µM -0.063196917068047 0.476781187338877 no 1774 0.474804849848821 2502 6624242
SGTC_1186 1319-0216 26 µM -0.0632324585643301 0.476767620582204 no 1775 0.474790699145301 2597 4565136
SGTC_337 1315-0038 354 µM -0.0634090636051706 0.476700208017659 no 1776 0.474720385031941 2543 1626437
SGTC_1498 4478-3555 97.6 µM -0.0638041228746333 0.47654941089706 no 1777 0.474563097685616 2503 3437919
SGTC_274 sirtinol 40.1 µM -0.0647194352192269 0.476200042170586 no 1778 0.474198694097803 2547 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3293 9120939 62.045 µM -0.0648290132515996 0.476158218174327 no 1779 0.474155070399747 2569 934087
SGTC_2045 5106652 78.05 µM -0.0681910271817465 0.474875126808866 no 1780 0.472816784809027 2566 673349
SGTC_2871 9038510 12.99 µM -0.0692423249271859 0.474473958517102 no 1781 0.472398366756576 2524 4945164
SGTC_2139 5578692 56.4705 µM -0.070185031433746 0.474114249923426 no 1782 0.472023194064598 2520 650991 YMR113W FOL3
SGTC_3181 9108277 49.47 µM -0.0743481604024894 0.47252598083824 no 1783 0.470366678290157 2549 17097298
SGTC_1178 0988-0033 191 µM -0.0743523382969911 0.472524387151126 no 1784 0.470365016151869 2639 5392207
SGTC_994 3910-0338 138 µM -0.0753193225199204 0.472155536132813 no 1785 0.469980324000678 2629 3479481
SGTC_2586 curcumin 80 µM -0.0759962938975946 0.471897323172036 no 1786 0.469711023357087 2617 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3039 9090270 49.47 µM -0.0762100029802815 0.471815811900303 no 1787 0.46962601230405 2542 17173750
SGTC_2055 5235184 200 µM -0.0766106087328996 0.471663019123886 no 1788 0.469466659605435 2618 2836034
SGTC_1240 0356-0016 42.1 µM -0.0769755753869801 0.471523822884571 no 1789 0.469321487661155 2608 4305613
SGTC_2575 plumbagin 510 nM -0.0772840545919314 0.471406173354074 no 1790 0.469198787778817 2539 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1209 2323-2347 50.3 µM -0.0779915242666098 0.471136364039064 no 1791 0.468917397556125 2527 5412760
SGTC_3030 9087619 49.47 µM -0.0789725322421078 0.470762256749127 no 1792 0.468527235452898 2560 25236973
SGTC_3313 9133968 57.047 µM -0.0790598539886144 0.470728957855828 no 1793 0.468492507698015 2534 1494643
SGTC_1681 tripelennamine 100 µM -0.0826287205953474 0.469368199607907 no 1794 0.467073381812556 2535 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_71 0417-1750 47.813 µM -0.0838348773426312 0.468908389220318 no 1795 0.466593858753898 2554 6811472
SGTC_2718 lomofungin 53.02 µM -0.0858693460899214 0.468132904481656 no 1796 0.465785139877814 2619 5351222 A RNA synthesis inhibitor.
SGTC_1611 st001856 99.4 µM -0.086351299313088 0.467949214486914 no 1797 0.465593579887422 2569 647478
SGTC_1174 0739-0097 51.1 µM -0.087361573486449 0.46756418425276 no 1798 0.465192056237291 2596 728447
SGTC_2954 9074818 52.69 µM -0.0879713223836356 0.467331814708693 no 1799 0.464949734587058 2634 16648742
SGTC_3240 9133527 49.47 µM -0.0884853414207557 0.467135935554601 no 1800 0.464745467244511 2549 17617455
SGTC_2752 diclazuril 33.15 µM -0.0896129754963269 0.466706251771895 no 1801 0.464297386470066 2620 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1330 1469-0054 61.8 µM -0.0899203667944437 0.466589127348817 no 1802 0.464175248176331 2663 7102664
SGTC_854 0422-0053 192 µM -0.089952291793595 0.466576963223797 no 1803 0.464162563349132 2575 3596728
SGTC_2269 7935389 174.42 µM -0.0907069504792163 0.466289430825689 no 1804 0.463862723859163 2554 97605
SGTC_1514 1189-1591 158 µM -0.0916778761431015 0.465919524477546 no 1805 0.463476987816274 2715 767698 YMR146C TIF34
SGTC_2782 7736369 71.43 µM -0.092129499301614 0.465747473662738 no 1806 0.463297575531111 2588 2950836 YOL077C BRX1
SGTC_1878 temozolomide 1 mM -0.0921534008922825 0.465738368266696 no 1807 0.463288080568037 2546 5394 DNA alkylating agent.
SGTC_510 ag-490 170 µM -0.0923085751917862 0.465679254501388 no 1808 0.463226437721694 2570 5328779
SGTC_707 0865-0008 204 µM -0.09279479706649 0.465494032824963 no 1809 0.463033292258222 2579 723043
SGTC_894 0960-0238 55.9 µM -0.0934530696474712 0.46524328195891 no 1810 0.462771815730909 2538 6741907 YDL195W SEC31
SGTC_1222 0366-0074 1.18 µM -0.0947412585484818 0.464752621784233 no 1811 0.462260172883331 2636 286520
SGTC_2099 5377090 177.372 µM -0.0955806938808259 0.464432916812262 no 1812 0.461926799519566 2653 2243829
SGTC_2429 5902844 64.44 µM -0.0958276528906613 0.464338865062748 no 1813 0.461828727295191 2687 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1489 4065-0444 182 µM -0.0961120877066893 0.464230543514807 no 1814 0.46171577557583 2581 2877968
SGTC_59 0330-0160 1.33 µM -0.0965274354439448 0.4640723710546 no 1815 0.461550842663067 2590 4293482
SGTC_2282 7944268 200 µM -0.0972060289258859 0.463813961746054 no 1816 0.461281390165616 2647 2970414
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0993612654927896 0.462993346522922 no 1817 0.460425718093171 2563 4620898
SGTC_993 3909-8757 62.7 µM -0.099438762584215 0.462963842097178 no 1818 0.46039495358508 2634 4288324 YLR208W SEC13
SGTC_318 1488-0629 67.2 µM -0.100060424731463 0.462727172411574 no 1819 0.460148177044367 2658 3662576
SGTC_911 3456-4043 236 µM -0.10214832532608 0.461932395942867 no 1820 0.459319471764072 2664 914281
SGTC_2005 4024620 188 µM -0.102519182829968 0.461791241799927 no 1821 0.45917229368663 2604 236743
SGTC_2079 5212404 121 µM -0.104207545032442 0.461148685937888 no 1822 0.458502323252095 2605 758462
SGTC_3096 9117468 49.47 µM -0.104299193225318 0.461113809411122 no 1823 0.458465959067869 2595 41316311
SGTC_1311 1190-0148 100 µM -0.104940319837177 0.460869838408618 no 1824 0.458211582489023 2681 1961333
SGTC_910 3454-3003 490 µM -0.10503985904686 0.460831961591454 no 1825 0.458172090349975 2586 820824
SGTC_82 0054-0107 293.755 µM -0.105157654288526 0.460787138419298 no 1826 0.458125355671495 2678 3104697
SGTC_2219 9098279 200 µM -0.105528281396652 0.460646111504189 no 1827 0.457978314981897 2600 902349
SGTC_3005 9076496 71.4286 µM -0.105727982804394 0.460570125391094 no 1828 0.457899088857044 2619 21368410
SGTC_817 1391-0715 46 µM -0.106141809334998 0.460412669547262 no 1829 0.457734919717269 2664 1353946
SGTC_65 0798-0905 34.986 µM -0.107044794318761 0.460069116583631 no 1830 0.457376721579336 2830 3602145
SGTC_1659 st012954 42.1 µM -0.109227890919048 0.459238651328966 no 1831 0.45651086944971 2702 24207262
SGTC_2995 9067767 71.4286 µM -0.109735012889072 0.459045763896642 no 1832 0.456309765907911 2678 11673567
SGTC_3072 9116419 49.47 µM -0.110058131257877 0.458922868562644 no 1833 0.456181636396896 2658 17170162
SGTC_201 4262-0159 12.803 µM -0.110597892344258 0.458717583768494 no 1834 0.455967609449664 2696 1341029
SGTC_2311 7694451 200 µM -0.111567350875016 0.458348901847073 no 1835 0.4555832302926 2674 2163142
SGTC_2892 9047358 58.44 µM -0.112021844937988 0.458176071552036 no 1836 0.455403042915559 2652 6466771
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.112364716201664 0.458045693249901 no 1837 0.455267115253445 2708 688798
SGTC_2427 5545055 42.75 µM -0.112389952420702 0.458036097245084 no 1838 0.455257110829795 2619 5372858
SGTC_1923 st058458 19.1 µM -0.11245107826269 0.45801285440848 no 1839 0.455232878758811 2773 3534982
SGTC_3195 9113082 49.47 µM -0.112515847940631 0.457988226175714 no 1840 0.45520720234647 2581 17018038
SGTC_317 4495-0002 170 µM -0.113820073291578 0.457492337744022 no 1841 0.454690212907967 2649 15991618
SGTC_2048 5246248 200 µM -0.114258620008513 0.457325609727795 no 1842 0.454516392032647 2631 677046
SGTC_2388 9080168 200 µM -0.116688467224399 0.456401959958001 no 1843 0.453553464829931 2604 15943073
SGTC_2164 5685496 200 µM -0.117193298918145 0.456210089344173 no 1844 0.453353438508455 2618 759046
SGTC_905 2-aminofluorene 215 µM -0.118618336144905 0.455668532849758 no 1845 0.452788868887048 2621 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2816 7982706 58.44 µM -0.118968613554243 0.455535429596302 no 1846 0.452650110949912 2711 2981853
SGTC_2430 5571206 200 µM -0.11936722852537 0.455383964439901 no 1847 0.452492211738044 2670 1731771
SGTC_1603 st002045 67.8 µM -0.119394416823826 0.455373633704472 no 1848 0.452481442192936 2630 5887985
SGTC_2212 7123476 200 µM -0.119452047533206 0.455351735868565 no 1849 0.452458614233242 2641 1085715
SGTC_443 clozapine 122 µM -0.122040037411952 0.45436852287515 no 1850 0.451433654984784 2598 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2969 9091408 28.7 µM -0.12236838349448 0.454243799534441 no 1851 0.451303638310022 2663 4286311
SGTC_698 k064-0052 127 µM -0.122457230898914 0.454210051330351 no 1852 0.451268457901202 2590 5088751
SGTC_288 1315-0019 35.1 µM -0.122708327503665 0.454114675436743 no 1853 0.451169034656156 2669 6811474
SGTC_3068 9116768 49.47 µM -0.123308956565208 0.453886544770885 no 1854 0.450931224324325 2704 41904888
SGTC_1032 k061-1018 98.7 µM -0.123874551305732 0.453671734732435 no 1855 0.450707301421575 2835 4005393
SGTC_2794 7785382 27.27 µM -0.124713851139149 0.453352997872002 no 1856 0.450375045697295 2600 2205081
SGTC_1118 chelidonine 707.474 nM -0.124952405796979 0.45326240859213 no 1857 0.450280614805157 2637 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3223 9129970 49.47 µM -0.125109954231817 0.453202582129962 no 1858 0.450218251440284 2650 17248386
SGTC_2272 7805186 180 µM -0.125864010172345 0.452916256350698 no 1859 0.449919785892291 2607 2956062 YPR165W RHO1
SGTC_161 4065-0411 162.148 µM -0.126327506300346 0.452740272408128 no 1860 0.449736341896841 2743 1906281 YLR208W SEC13
SGTC_1848 st056003 16.4 µM -0.12727009298547 0.452382412175166 no 1861 0.449363315065377 2608 146492
SGTC_2845 9003024 42.97 µM -0.128655500353921 0.451856501973348 no 1862 0.448815124127149 2848 2990173
SGTC_1188 1403-0014 4.57 µM -0.128889904231693 0.451767528973105 no 1863 0.448722382644956 2646 9614867
SGTC_223 busulfan 5 mM -0.128936172721139 0.451749967065479 no 1864 0.448704076929394 2733 2478 A DNA alkylator.
SGTC_2423 st077119 87.2 µM -0.128973163280729 0.451735926804906 no 1865 0.448689442022659 2571 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2077 5212015 200 µM -0.12949162261404 0.451539145006157 no 1866 0.448484326664568 2601 780900
SGTC_1686 st019653 115.5 µM -0.130123828866896 0.451299206558455 no 1867 0.448234228845412 2624 97252
SGTC_2001 4023502 57.655 µM -0.130438574432668 0.451179759191931 no 1868 0.448109724645233 2728 108941 YCR052W RSC6
SGTC_2910 7948405 25.97 µM -0.131038489782517 0.450952100853446 no 1869 0.447872429730896 2706 2971328
SGTC_2885 9057732 51.95 µM -0.1322470837457 0.450493507725422 no 1870 0.447394430346621 2765 6471414
SGTC_1379 2144-0755 36.5 µM -0.132734802111906 0.450308464840989 no 1871 0.447201559138077 2711 5392327
SGTC_3058 9093861 49.47 µM -0.133121915287181 0.450161599776586 no 1872 0.447048481752864 2780 17217477
SGTC_3245 9134821 49.47 µM -0.133628793454239 0.449969307951802 no 1873 0.446848057248949 2633 17014901
SGTC_627 1391-0720 175 µM -0.133756156468398 0.449920992729459 no 1874 0.44679769881984 2730 997839
SGTC_1307 1187-1599 12.2 µM -0.133804853676786 0.449902519615529 no 1875 0.446778444516984 2636 1538471
SGTC_2679 rapamycin 1 nM -0.133966576068449 0.449841171576818 no 1876 0.446714502287783 2681 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2177 5811945 192 µM -0.134779705218798 0.449532736019215 no 1877 0.446393026148932 2781 5343475
SGTC_258 haloperidol 50.781 µM -0.135176805305098 0.449382119372313 no 1878 0.446236042720073 2666 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2479 5617353 43.85 µM -0.135590926654178 0.449225054475567 no 1879 0.446072339343821 2764 2731746
SGTC_562 3772-2733 112 µM -0.136227434762172 0.448983659885778 no 1880 0.445820743764641 2711 2876874 YIL048W NEO1
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.137837406703114 0.448373165321705 no 1881 0.445184460118449 2639 97141
SGTC_1452 4194-0072 190 µM -0.138207489304588 0.448232848788439 no 1882 0.445038218146628 2826 1343545
SGTC_2438 5259590 200 µM -0.138297533968517 0.448198709402395 no 1883 0.445002637195959 2766 1201127
SGTC_146 3448-8650 53.125 µM -0.138444353939744 0.448143045142434 no 1884 0.444944622557986 2683 2891488 YIL048W NEO1
SGTC_3323 9138564 53.9225 µM -0.138483252108103 0.448128297743806 no 1885 0.444929252481744 2751 43912313 YNL103W MET4
SGTC_54 0159-0055 9 µM -0.138739755602011 0.448031051791809 no 1886 0.4448279007281 2783 3319099
SGTC_294 k038-0071 157 µM -0.139195127548649 0.447858418260257 no 1887 0.444647979338049 2707 24152826
SGTC_492 tmb-8 126 µM -0.140444650542895 0.447384769356062 no 1888 0.444154340696245 2639 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_929 2805-0021 398 µM -0.14104764289858 0.447156223594031 no 1889 0.443916152468841 2763 3098024
SGTC_3346 9158254 43.5805 µM -0.141503703171969 0.446983379582336 no 1890 0.443736017385999 2748 17639500
SGTC_2812 7970281 58.44 µM -0.141639661884242 0.446931854021589 no 1891 0.443682318543367 2776 2233435
SGTC_2069 5228469 200 µM -0.142168760170494 0.446731345167451 no 1892 0.443473353440994 2768 2835210
SGTC_2643 anethole 100 µM -0.142498144959394 0.446606527281466 no 1893 0.443343272263871 2664 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_33 0986-0033 35.816 µM -0.142797563324865 0.44649306953532 no 1894 0.443225030772641 2656 2848082
SGTC_3260 9137109 49.47 µM -0.142846752760226 0.446474430741702 no 1895 0.443205606154182 2726 17478346
SGTC_1056 3448-1962 115 µM -0.144827894266512 0.445723838045824 no 1896 0.442423378986032 2766 715507
SGTC_1045 1348-1485 165 µM -0.146853929499559 0.444956437679468 no 1897 0.441623658248442 2650 6810614
SGTC_1725 st036284 20.55 µM -0.147890754917805 0.444563799423531 no 1898 0.441214492240654 2910 707914
SGTC_935 2996-0153 430 µM -0.148294251543629 0.444411012862986 no 1899 0.441055275903125 2686 23738523
SGTC_2181 6316240 54.2555 µM -0.148976583571403 0.444152662311949 no 1900 0.440786055176621 2755 12779990
SGTC_2878 9043973 25.97 µM -0.149137119839875 0.444091882102741 no 1901 0.440722718005263 2842 6465167
SGTC_1064 honokiol 6.76 µM -0.149206289623261 0.444065694320448 no 1902 0.440695428574414 2750 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_55 0767-0285 6.563 µM -0.151371809108555 0.443245949524781 no 1903 0.439841213132987 2753 3116166
SGTC_1736 st036774 51 µM -0.151582880712445 0.443166062529848 no 1904 0.439757968288171 2950 1272247
SGTC_367 0335-0881 7.1 µM -0.152586649587668 0.442786184835339 no 1905 0.439362126895416 2811 23828853
SGTC_1473 k844-0725 134 µM -0.153331006561106 0.442504515867643 no 1906 0.439068625038667 2696 54682906
SGTC_2705 st078069 42.8 µM -0.153342013608771 0.442500350955078 no 1907 0.439064285182577 2750 1530061
SGTC_2880 9042983 58.44 µM -0.153343220041969 0.442499894458052 no 1908 0.439063809510833 2816 6464714
SGTC_1325 1431-0015 227 µM -0.153820837554635 0.442319176842459 no 1909 0.438875501690283 2680 1103340
SGTC_2391 6285546 200 µM -0.153999248119018 0.44225167416252 no 1910 0.438805164213784 2650 846083
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.155140449096195 0.441819933847938 no 1911 0.438355297219692 2778 616764
SGTC_1122 capsaicin 818.572 nM -0.15547927626689 0.441691761690501 no 1912 0.438221745202769 2817 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2982 9019404 25.97 µM -0.156166013787855 0.441432000114966 no 1913 0.43795108254155 2706 22333232
SGTC_1801 st050089 28.441 µM -0.157198275609987 0.441041589833201 no 1914 0.437544293635014 2675 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1364 1653-0028 37.6 µM -0.159427117820436 0.440198818461698 no 1915 0.436666187603195 2759 5718652
SGTC_3085 9117376 49.47 µM -0.159738146158836 0.440081233658708 no 1916 0.436543675211332 2757 16480349
SGTC_1831 st055328 12 µM -0.159812048172942 0.440053295650652 no 1917 0.436514566499419 2799 1103068
SGTC_1986 st071812 45 µM -0.160409291168953 0.439827524140968 no 1918 0.436279335549276 2700 11838594
SGTC_2144 5628481 200 µM -0.161863912943779 0.439277725853342 no 1919 0.435706510654702 2690 2818399
SGTC_2148 5546263 113.568 µM -0.162169858018083 0.439162103738422 no 1920 0.435586047694976 2682 792097
SGTC_2348 9022543 33.42 µM -0.16273448084998 0.438948736308419 no 1921 0.435363748532315 2819 3162678 YDL140C RPO21
SGTC_786 4544-0069 423 µM -0.162936830154048 0.438872274089023 no 1922 0.43528408601549 2826 748821 YLR208W SEC13
SGTC_863 0466-0191 129 µM -0.163304253592026 0.438733440742133 no 1923 0.435139442489991 2744 765160 YPR165W RHO1
SGTC_2215 7188065 200 µM -0.16416825215502 0.438407002972544 no 1924 0.434799346547407 2824 940217
SGTC_3239 9133757 49.47 µM -0.165518048484383 0.437897104003405 no 1925 0.434268122560216 2689 17036923
SGTC_3243 9134147 49.47 µM -0.166064737083747 0.437690616242117 no 1926 0.43405300225864 2709 24282180
SGTC_802 4112-3352 742 µM -0.167860379444936 0.43701251038548 no 1927 0.433346560200264 2845 704594
SGTC_48 0382-0018 55 µM -0.168224242518651 0.43687512372006 no 1928 0.433203434970729 2955 762596
SGTC_807 1315-0151 48 µM -0.169622590223308 0.436347209481531 no 1929 0.43265347778284 2817 4011080
SGTC_2829 7992743 58.44 µM -0.170551505461197 0.435996581356833 no 1930 0.432288216067691 2892 16462845
SGTC_3062 9077494 49.47 µM -0.170696577626754 0.435941826985625 no 1931 0.432231176996285 2816 16459633
SGTC_1299 1079-1439 3.74 µM -0.170978918470898 0.435835267022511 no 1932 0.432120171057355 2732 323161
SGTC_26 0302-0163 425.158 µM -0.172639935709605 0.435208467033153 no 1933 0.43146722951495 2704 3100915
SGTC_1787 fluconazole 80 µM -0.173197953541095 0.434997930367301 no 1934 0.431247916085478 2745 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.173560865560428 0.434861015799851 no 1935 0.431105294953791 2753 2374 Ca(2+)-ATPase inhibitor.
SGTC_2627 acetyl isogambogic acid 100 µM -0.173958564171141 0.434710986384899 no 1936 0.430949013323803 2812 6857789 A caspase activator and apoptosis inducer.
SGTC_878 0828-0289 13.7 µM -0.174824390461426 0.434384391152026 no 1937 0.430608811329299 2732 745350 YLR208W SEC13
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.17568883886081 0.434058360337707 no 1938 0.43026920210678 2740 390807
SGTC_284 0988-0104 32.6 µM -0.1768640105852 0.433615210720776 no 1939 0.429807604151107 2820 4666532
SGTC_2528 xanthyletin 44.79 µM -0.177840644893289 0.433246991732421 no 1940 0.429424063051295 2747 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1113 artemisinin 1.17947 µM -0.179017353503429 0.432803416013808 no 1941 0.428962037838059 2800 2240 An anti-malaria and mitochondrial poison.
SGTC_2004 4023728 41.89 µM -0.180430053957763 0.432270991956052 no 1942 0.428407480920027 2821 360084 YDR527W RBA50
SGTC_1370 2001-0092 44.6 µM -0.180804600369693 0.432129852027397 no 1943 0.428260476026229 2871 790957
SGTC_2029 5175081 200 µM -0.180969436752792 0.432067739651 no 1944 0.428195782911767 2721 1380876
SGTC_3261 9137475 49.47 µM -0.181591765828411 0.431833253550556 no 1945 0.427951555663723 2697 17027690
SGTC_1591 genipin 88.4 µM -0.182185364752886 0.431609615001054 no 1946 0.427718629011312 2882 442424 A DNA cross-linking agent.
SGTC_2791 5663188 71.43 µM -0.182462212115897 0.431505320175772 no 1947 0.427610003444673 2880 54690634
SGTC_2355 9061122 103.12 µM -0.18260929616825 0.431449912142298 no 1948 0.427552294855404 2859 5302957
SGTC_2483 5729050 27.16 µM -0.184313930764247 0.430807857917887 no 1949 0.42688359298807 2829 2865180
SGTC_3163 9099914 49.47 µM -0.185341252743169 0.430421003111679 no 1950 0.426480691744064 2793 16268368
SGTC_248 streptozotocin 5.23457 mM -0.186058893445645 0.430150803418695 no 1951 0.426199288628318 2823 5300 DNA alkylating agent.
SGTC_2661 dactinomycin 12.96 µM -0.186327725924582 0.430049593419302 no 1952 0.426093883012011 2729 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_12 0849-0099 9.267 µM -0.187891692356839 0.429460882993778 no 1953 0.425480777647256 2721 6071388
SGTC_1019 4262-0212 3.4 µM -0.188438871222378 0.429254950130773 no 1954 0.425266315316067 2803 4677213
SGTC_1548 st061468 90.8 µM -0.19147814838202 0.428111458492616 no 1955 0.424075499432322 2858 390799
SGTC_2827 7993847 71.43 µM -0.192242534924164 0.427823961796355 no 1956 0.423776114586835 2868 2985692
SGTC_1006 4099-6547 255 µM -0.193569087889715 0.427325117308154 no 1957 0.423256652321319 2845 3146833
SGTC_2551 apiole 73.87 µM -0.19383659033385 0.427224538224569 no 1958 0.423151917696084 2735 10659 A possible DNA adduct former.
SGTC_1179 1021-1431 9.29 µM -0.194785036854214 0.426867967003037 no 1959 0.422780618391226 2833 2840958
SGTC_1077 5-fluorocytosine 377 nM -0.194846151689398 0.426844992749474 no 1960 0.422756695410176 2824 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3306 9127676 59.7925 µM -0.195283271350639 0.426680678218555 no 1961 0.422585596241829 2822 41905287
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.195518429273965 0.426592286944361 no 1962 0.422493555804099 2755 5106787 A p450 inhibitor.
SGTC_804 1595-0054 20.9 µM -0.19583489122385 0.426473340892987 no 1963 0.422369699779642 2772 761523 Stimulates phospholipase C.
SGTC_2434 5670830 169.91 µM -0.195950536979751 0.42642987570474 no 1964 0.42232444056994 2848 1549830
SGTC_3089 9117425 49.47 µM -0.19647467915282 0.426232889298533 no 1965 0.422119324762869 2824 9401657
SGTC_621 3584-0052 32.1 µM -0.197265922034315 0.425935554299716 no 1966 0.421809722806419 2790 2273927
SGTC_1230 0170-0365 3.77 µM -0.197569758188867 0.425821389256827 no 1967 0.421690848920123 2852 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1465 k213-0056 144 µM -0.198299060899464 0.425547382496271 no 1968 0.421405543197308 2749 24048857 YMR208W ERG12
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.199426885533746 0.425123717658151 no 1969 0.420964415618154 2910 551469
SGTC_1583 clindamycin 39.6 µM -0.19982142790083 0.424975529075547 no 1970 0.420810121122226 2750 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2769 toremifene 3.73 µM -0.201284550398396 0.424426078650262 no 1971 0.420238041169922 2939 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_246 cycloheximide 667 µM -0.20191129994261 0.424190758523801 no 1972 0.419993033969598 2754 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2127 5253358 187.912 µM -0.20262730811985 0.423921958320738 no 1973 0.419713171976952 2733 20612
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.205258062934165 0.422934638361475 no 1974 0.41868525367858 2795 688801
SGTC_2160 5660466 132.927 µM -0.206174165074489 0.422590939301525 no 1975 0.418327433795864 2730 2859134
SGTC_1971 st069429 63.5 µM -0.206896994115622 0.422319793144364 no 1976 0.418045152039069 2908 1246522 YGL099W LSG1
SGTC_2020 4017018 200 µM -0.207067429671694 0.422255865063947 no 1977 0.417978599086992 2865 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2601 securinine 100 µM -0.208775562361322 0.421615280903423 no 1978 0.417311724678752 2792 442872 A GABA receptor antagonist.
SGTC_1471 k673-0312 37 µM -0.20884472818047 0.42158934668548 no 1979 0.41728472655357 2798 24099884
SGTC_21 0849-0113 22.993 µM -0.211989246904046 0.420410647864816 no 1980 0.416057711703888 2792 1560156
SGTC_713 1488-1073 324 µM -0.212246851802154 0.420314118106772 no 1981 0.415957228414476 2771 3312542
SGTC_94 0334-0113 514.748 µM -0.213517410198867 0.419838084434237 no 1982 0.415461705416185 2806 6795178
SGTC_1965 Pectolinarigenin 58.4 µM -0.214021928640765 0.419649091556069 no 1983 0.415264978389829 2795 5320438 An anti-inflammatory.
SGTC_997 3996-0078 137 µM -0.215326859996455 0.419160349630521 no 1984 0.414756244755067 2854 735687
SGTC_652 0437-0092 114 µM -0.216158075168669 0.418849095772189 no 1985 0.414432266070197 2791 3091274
SGTC_1988 st071872 53.4 µM -0.216674667620435 0.418655679990846 no 1986 0.414230945663415 2886 16414116
SGTC_2823 7987624 58.44 µM -0.217589528696992 0.418313197959638 no 1987 0.413874471956269 2985 2239440
SGTC_2207 7258803 200 µM -0.219600530816778 0.417560588994723 no 1988 0.413091138984661 2877 3666799
SGTC_1803 st050068 52.4 µM -0.219922495238573 0.417440123147079 no 1989 0.41296575825449 2792 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_77 0828-0286 12.516 µM -0.220185218085027 0.417341828801554 no 1990 0.412863454203131 2755 745345
SGTC_1949 st076024 69.1 µM -0.220681121750763 0.417156306958324 no 1991 0.412670365873362 2731 2921930
SGTC_2216 7189485 200 µM -0.220757485030944 0.417127740433561 no 1992 0.412640634437997 2892 731273
SGTC_1484 3473-2379 286 µM -0.222787303601864 0.416368572137475 no 1993 0.411850524972142 2792 671917
SGTC_2101 5377231 179.231 µM -0.222977948078984 0.416297285564004 no 1994 0.411776334669454 2930 2844213
SGTC_2362 9071156 126 µM -0.223537305449658 0.416088144234589 no 1995 0.41155867601228 2980 653133
SGTC_1151 3909-8316 15.3 µM -0.223929557586543 0.415941497006556 no 1996 0.411406058026238 2901 800431
SGTC_2851 9015922 71.43 µM -0.224043837522459 0.415898774555797 no 1997 0.411361596356556 2996 2996893
SGTC_1796 st049173 110.4 µM -0.224632443885189 0.41567874550293 no 1998 0.4111326116316 2804 94134
SGTC_3001 9076041 71.4286 µM -0.225067406913544 0.415516167395331 no 1999 0.410963418009837 2791 16004211
SGTC_2856 9022925 19.48 µM -0.225380307246866 0.415399222157798 no 2000 0.410841715054199 2952 4944862
SGTC_2002 4023503 131 µM -0.225529041466212 0.415343635970257 no 2001 0.410783867711908 2859 4736863 YCR052W RSC6
SGTC_3048 9093155 49.47 µM -0.227045577461125 0.414776960443782 no 2002 0.410194150886336 2856 25236002
SGTC_2067 5224629 34.075 µM -0.228725384278076 0.414149483414656 no 2003 0.409541181964653 2960 2835000
SGTC_2964 9083345 53.42 µM -0.229020486603671 0.414039273121059 no 2004 0.409426496623346 2857 17741579
SGTC_1440 4100-1550 40 µM -0.229257422925422 0.41395079067406 no 2005 0.409334421891064 2817 742806
SGTC_245 methotrexate 289.6 µM -0.23073985734203 0.413397283774947 no 2006 0.408758453614161 2885 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_593 1203-0218 61.7 µM -0.231327481880757 0.413177925853191 no 2007 0.408530199081112 2950 3666956
SGTC_2387 9077560 195.08 µM -0.231355939438011 0.413167303446824 no 2008 0.40851914592806 2816 5303272
SGTC_3034 9090421 49.47 µM -0.23385773608522 0.412233702360144 no 2009 0.407547712578019 2800 17173761
SGTC_947 3447-0010 211 µM -0.236186324730281 0.411365183626218 no 2010 0.406644045327202 2791 748350
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.237310851864862 0.410945911858511 no 2011 0.406207821982148 2809 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3215 9129942 49.47 µM -0.237478333505619 0.410883476237455 no 2012 0.406142862929819 2933 17682944
SGTC_2088 5278280 127.392 µM -0.237957469134725 0.410704871338787 no 2013 0.405957040736736 2916 791502
SGTC_292 k038-0015 474 µM -0.238186424332934 0.410619531434162 no 2014 0.405868252987429 2940 46368540
SGTC_2405 ticlatone 3.52 µM -0.239640325590888 0.410077708624311 no 2015 0.405304550093693 2721 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_41 0478-0632 82.643 µM -0.242081338432813 0.409168407155784 no 2016 0.404358568989871 2840 3750424
SGTC_2639 lactacystin 53 µM -0.243161842888621 0.408766064233021 no 2017 0.403940012399516 2982 3870 A proteasome inhibitor.
SGTC_978 1416-0512 87.4 µM -0.244337298918263 0.408328473767413 no 2018 0.40348479916903 2902 6814003
SGTC_2990 9074105 71.4286 µM -0.245460110127538 0.407910588257348 no 2019 0.403050095509082 2885 6502001
SGTC_1464 k208-0027 110 µM -0.247124583820564 0.407291300790599 no 2020 0.402405904261424 3040 X1464
SGTC_892 0929-0076 29 µM -0.24961588300438 0.406364816249228 no 2021 0.401442207240391 2870 5751038
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.249739389055404 0.40631889940751 no 2022 0.401394447541891 2954 756377
SGTC_3259 9138485 49.47 µM -0.250264692360284 0.406123617556629 no 2023 0.401191329608059 3146 17646153
SGTC_2287 7945887 168.79 µM -0.251013191886843 0.405845402717496 no 2024 0.400901954998204 2954 1245853
SGTC_460 trequinsin 123 µM -0.251515666011901 0.405658661384667 no 2025 0.400707725838703 2921 5537 A vasodilator.
SGTC_648 0375-0473 33.3 µM -0.251727523399666 0.40557993235717 no 2026 0.40062584065227 2863 1713139
SGTC_2165 5727197 32.143 µM -0.251796040848581 0.405554471177657 no 2027 0.400599358846812 3245 1361712
SGTC_487 nimodipine 119 µM -0.251855436542395 0.405532399978397 no 2028 0.400576402944281 2926 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1259 0671-0132 43 µM -0.252995090419 0.405108967464087 no 2029 0.400136003546426 2872 X1259
SGTC_2108 5365811 200 µM -0.253200494036348 0.40503266260837 no 2030 0.40005664238264 2968 780283
SGTC_2549 cedrol 20.94 µM -0.253249019720295 0.405014636455325 no 2031 0.400037894265998 3028 6708665 A sedative which affects the nervous system.
SGTC_3052 9092717 49.47 µM -0.253330328798004 0.404984432492463 no 2032 0.400006480653932 3028 25237534
SGTC_1487 3970-0795 2.82 µM -0.253802962096168 0.404808874150319 no 2033 0.399823892470007 2936 3765103
SGTC_688 0527-0193 473 µM -0.255127344242376 0.40431703820152 no 2034 0.399312372582049 2879 4007154
SGTC_2708 st078559 56 µM -0.255451070518942 0.404196838901615 no 2035 0.399187365110698 2934 17250902
SGTC_1943 st076331 65.2 µM -0.256698616510133 0.40373371077825 no 2036 0.398705719817413 2956 24208415
SGTC_1728 st035614 33.7865 µM -0.256789111553316 0.40370012142678 no 2037 0.398670788008707 2953 15945546
SGTC_102 gallobenzophenone 83.616 µM -0.259044649485121 0.402863155843662 no 2038 0.397800395312754 3043 70837
SGTC_2676 harmalol 100 µM -0.259851047179364 0.402564032502901 no 2039 0.397489336536182 2958 5459187 A monoamine oxidase inhibitor
SGTC_1932 st074806 40.9 µM -0.260241489121398 0.402419223331832 no 2040 0.397338751385066 3105 17251235
SGTC_2199 6590217 200 µM -0.262325604979615 0.401646482373503 no 2041 0.396535211560615 2927 703109
SGTC_1007 4101-0031 70 µM -0.26464342060323 0.40078754264217 no 2042 0.395642083751595 3040 1146276
SGTC_767 0929-0023 86 µM -0.264872743010468 0.400702585983702 no 2043 0.395553748261863 2892 1204563
SGTC_2260 7964312 200 µM -0.265141861071766 0.400602892291264 no 2044 0.395450090242884 3042 231951
SGTC_2321 7390090 138.78 µM -0.265644642721144 0.400416656223639 no 2045 0.395256450265724 2950 649046
SGTC_2945 9067681 61.76 µM -0.267746538432957 0.399638335646128 no 2046 0.394447212347413 2822 16456930
SGTC_1159 4092-0538 61.2 µM -0.267815884297919 0.399612664024713 no 2047 0.394420521663234 2892 717301
SGTC_2487 5918373 44.05 µM -0.268039910742291 0.399529733104766 no 2048 0.394334299014815 2921 2876279
SGTC_101 0490-5701 117.494 µM -0.268178856868482 0.3994782998022 no 2049 0.39428082443369 2851 4661669
SGTC_2211 7117706 200 µM -0.270737075041762 0.398531643896744 no 2050 0.393296629790833 2976 822771
SGTC_1719 st032227 49.2 µM -0.271107201429891 0.398394729752864 no 2051 0.393154291494065 2896 3125804
SGTC_2924 9010168 62.78 µM -0.271150999312316 0.398378529223531 no 2052 0.393137449230059 2978 2993929
SGTC_1970 st070122 35.8 µM -0.271320161040346 0.398315959132377 no 2053 0.393072400783521 3061 102928
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.272354231829877 0.397933530551945 no 2054 0.392674830310339 2940 75037 A free radical scavenger.
SGTC_539 4859-0462 2.54 µM -0.272742085557745 0.397790116554046 no 2055 0.392525740557879 3052 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_136 0097-0015 404.482 µM -0.272827560163686 0.397758513055086 no 2056 0.392492886508305 2898 4861337
SGTC_428 3448-4153 16.5 µM -0.273726023898064 0.397426354463261 no 2057 0.392147588555325 2832 3834874
SGTC_2267 7931562 200 µM -0.273857600411157 0.397377717368807 no 2058 0.392097028137237 2843 934880
SGTC_1138 3761-0006 1.03 µM -0.275031031995987 0.396944030493169 no 2059 0.391646198607193 2875 12061087
SGTC_3328 9140624 29.0385 µM -0.275660987504112 0.396711258681077 no 2060 0.391404231224735 3061 4904392
SGTC_1897 st060201 15 µM -0.276379372120204 0.396445856773761 no 2061 0.391128349296005 2917 611878
SGTC_2183 6420625 130.508 µM -0.276443262695332 0.396422255192538 no 2062 0.39110381598775 2875 2897619
SGTC_2949 9072542 2.23 µM -0.276770433202541 0.396301402294598 no 2063 0.39097819274982 2992 16457352
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.277973644292583 0.395857036200645 no 2064 0.390516295271781 2898 165521
SGTC_610 4215-0184 155 µM -0.279807421131583 0.395180052011863 no 2065 0.389812628901175 2944 5605015
SGTC_1606 st000094 49.2 µM -0.281111979109099 0.394698634485048 no 2066 0.389312256748157 3042 1242210
SGTC_642 0335-0876 158 µM -0.281264545362937 0.394642343855542 no 2067 0.389253750883511 2903 6812350
SGTC_1060 3448-7350 82 µM -0.283122018569862 0.393957189913133 no 2068 0.388541651729823 3028 570178
SGTC_981 1488-1094 54.9 µM -0.283860947570775 0.393684717126483 no 2069 0.388258472624863 2860 3449522
SGTC_1170 0310-0127 64.8 µM -0.284285515643026 0.393528185368621 no 2070 0.388095792636259 2983 774975
SGTC_1142 3253-1408 9.78 µM -0.284356560157377 0.393501994022024 no 2071 0.388068572721013 2975 256655
SGTC_1279 0874-0590 65.2 µM -0.285233274407293 0.393178823309503 no 2072 0.387732714712339 2965 3523074
SGTC_234 nsc-17383 10.7 µM -0.286419864816471 0.392741544602538 no 2073 0.387278280902471 3061 408974
SGTC_407 eburnamonine 100 µM -0.286570195012223 0.392686155021916 no 2074 0.387220719287164 2891 3195
SGTC_218 alverine citrate 93.75 µM -0.287217194874372 0.392447790933519 no 2075 0.386973010568061 3045 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1415 3966-0071 78.1 µM -0.288316403723952 0.392042919060611 no 2076 0.386552275843313 2949 2893185
SGTC_1412 3909-8563 178 µM -0.288442231673328 0.391996580266388 no 2077 0.386504122255754 3011 23767530
SGTC_3344 9148862 3.898 µM -0.290050417050956 0.391404467227647 no 2078 0.385888833685514 3084 4905352
SGTC_1752 st044819 83.042 µM -0.290715712239163 0.39115958762885 no 2079 0.38563437687406 2932 441209 YML126C ERG13
SGTC_3027 9089541 49.47 µM -0.29185213352035 0.390741397363498 no 2080 0.385199841379335 3016 9943819
SGTC_2697 mebhydrolin 72.4 µM -0.292117923008957 0.390643608028788 no 2081 0.385098231737053 3074 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1418 3966-3099 2.4 µM -0.292469316638441 0.390514333814438 no 2082 0.384963908282855 3014 740335
SGTC_1340 1486-1359 257 µM -0.293050319712288 0.390300615127841 no 2083 0.384741844789781 2932 4309068
SGTC_415 dibenzyl ketone 100 µM -0.294537063368036 0.389753875980172 no 2084 0.384173773138474 2999 7593
SGTC_177 1327-0068 8.361 µM -0.29480990436317 0.389653564343379 no 2085 0.384069549972896 2990 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1546 5-methoxyflavanone 78.7 µM -0.296639008393393 0.388981273341959 no 2086 0.38337106309842 2998 147795
SGTC_2565 isoliquiritigenin 100 µM -0.297066657065658 0.38882413803196 no 2087 0.383207809851535 3057 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2493 resveratrol 26.09 µM -0.298090418436226 0.388448040884219 no 2088 0.382817077158832 2896 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_853 0419-0306 21 µM -0.298663741382007 0.388237466042175 no 2089 0.382598312578368 2912 762713
SGTC_1957 st077035 62.4 µM -0.299760591923466 0.387834697199494 no 2090 0.382179888412523 3040 705593
SGTC_1623 st003709 20.3 µM -0.300046193929956 0.387729842536337 no 2091 0.382070960131095 2919 16192618
SGTC_1709 st033179 39.1045 µM -0.301871234725659 0.387059998706417 no 2092 0.381375112381171 2937 573381
SGTC_2485 5633444 17.78 µM -0.302220838904098 0.386931721965357 no 2093 0.381241859704058 3026 5724239
SGTC_3074 9116018 49.47 µM -0.302814785641161 0.386713819388792 no 2094 0.381015507414904 2903 17027303
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.303054539088063 0.386625870614687 no 2095 0.380924149232528 3053 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_873 0591-4978 488 µM -0.303330501656126 0.386524646454558 no 2096 0.380819001762079 3144 3305145
SGTC_279 1273-0055 2.93 µM -0.303568610267535 0.386437313479875 no 2097 0.380728284508295 3013 2847562
SGTC_3232 9132874 49.47 µM -0.30397249848747 0.386289189365476 no 2098 0.380574421701234 2942 3784940
SGTC_286 k060-0067 22.9 µM -0.304379645549473 0.386139886857564 no 2099 0.380419336543465 2971 5985051
SGTC_2987 9018338 71.43 µM -0.304541949156799 0.386080374153824 no 2100 0.380357519322762 3016 5055682
SGTC_1847 st056231 15 µM -0.30805792835965 0.384791812086812 no 2101 0.379019126860739 2945 5393180
SGTC_799 1310-0557 151 µM -0.308162419043675 0.384753536954175 no 2102 0.378979373537299 3095 5354492
SGTC_556 4058-0063 51.5 µM -0.308166428096676 0.384752068452947 no 2103 0.378977848324615 2999 6615692
SGTC_1871 st057448 67.3 µM -0.310171834958366 0.384017703053125 no 2104 0.378215143738624 3155 691747
SGTC_3300 9124615 50.48 µM -0.314998734822798 0.382251838683521 no 2105 0.3763813072353 3138 24824903
SGTC_3339 9145883 14.936 µM -0.315560120961029 0.3820466202894 no 2106 0.376168205460334 3097 2030670
SGTC_1866 st057638 64 µM -0.315676819886533 0.382003964388008 no 2107 0.376123911369041 2977 688802
SGTC_1793 st048256 72.231 µM -0.315886807981931 0.381927212949054 no 2108 0.376044212672694 2935 672022
SGTC_2242 6630449 61.2675 µM -0.317778280999849 0.381236081940546 no 2109 0.375326563321372 3107 691249 YDR170C SEC7
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.320623474939761 0.380197181664048 no 2110 0.3742478728299 2984 2724 A muscle relaxant with antifungal properties.
SGTC_1993 st073995 70.8 µM -0.3232404482584 0.379242376676199 no 2111 0.37325657519801 2999 3098394
SGTC_1475 4092-1048 11.7 µM -0.323927757785497 0.378991733021514 no 2112 0.372996364194728 3048 2881759
SGTC_2560 caryophyllene 100 µM -0.324081310403315 0.37893574338078 no 2113 0.372938238065446 2949 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1868 st057644 42.7 µM -0.325576045490287 0.378390853443243 no 2114 0.372372569225074 2954 688665
SGTC_3318 9139014 38.6185 µM -0.326385435619627 0.378095899609147 no 2115 0.372066377714381 2978 16643984
SGTC_78 0336-0123 156.75 µM -0.326448742023328 0.378072832804681 no 2116 0.37204243237045 2905 6765896
SGTC_1977 st070720 65.3 µM -0.328331205986423 0.377387122819435 no 2117 0.371330625906755 3086 682188
SGTC_1882 5615643 20 µM -0.329013452033801 0.377138701819702 no 2118 0.371072760165787 3039 2253075
SGTC_668 1682-0499 62.6 µM -0.331546581991797 0.376216778286502 no 2119 0.370115830649141 3026 682214
SGTC_307 1501-1223 22.3 µM -0.331875531454958 0.376097109984535 no 2120 0.369991623654962 3072 2830329
SGTC_3291 9121177 71.43 µM -0.33298239311792 0.375694533070701 no 2121 0.369573786876926 3028 17015612
SGTC_1842 st055362 61.2 µM -0.333801251487296 0.375396792939151 no 2122 0.369264769495431 2991 676032
SGTC_1341 1486-1360 280 µM -0.334071357096846 0.375298597741845 no 2123 0.369162856673036 2980 3976547
SGTC_1849 st056239 19.2 µM -0.334667898915041 0.375081757347845 no 2124 0.368937809671843 2989 5393181
SGTC_1081 sertraline 6 µM -0.335716980028266 0.374700516649487 no 2125 0.368542150022599 3108 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_867 0518-0118 155 µM -0.33954810193068 0.373309312578345 no 2126 0.36709843344718 3102 6848158
SGTC_2872 9044037 25.97 µM -0.339661222030388 0.373268260006714 no 2127 0.367055833803595 2991 6465195
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.341083547520217 0.372752204798257 no 2128 0.366520343280686 3015 229346 A bile salt which induces apoptosis.
SGTC_2118 5526350 200 µM -0.342370082847772 0.37228561426237 no 2129 0.366036200003901 3099 743594
SGTC_2065 5221596 34.26 µM -0.34258136425074 0.372209006280465 no 2130 0.365956711884989 3139 788581
SGTC_450 aminopyrene 156 nM -0.343493568819865 0.371878310454376 no 2131 0.365613589099721 3123 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3124 9127567 49.47 µM -0.343554238078997 0.371856319755645 no 2132 0.365590772364651 3197 17592030
SGTC_2129 girgensonine 121.053 µM -0.343835342208029 0.371754433805097 no 2133 0.365485059819085 3067 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2078 5212016 200 µM -0.345713037857902 0.371074095319153 no 2134 0.364779192488963 3063 1899708
SGTC_3177 9107506 49.47 µM -0.346548200419058 0.370771623250008 no 2135 0.364465383455132 3117 8897194
SGTC_2680 butyl paraben 22.24 µM -0.346573095177861 0.370762608302707 no 2136 0.36445603074068 3061 7184 An antifungal and steroid mimetic.
SGTC_1008 4106-0037 6 µM -0.347355187371712 0.370479431427975 no 2137 0.364162247559802 2945 2905394
SGTC_1318 1280-3875 124 µM -0.348108864072348 0.370206609507848 no 2138 0.363879213805922 3077 373245
SGTC_1146 3579-1023 7 µM -0.348750732156781 0.369974312435177 no 2139 0.363638226900848 3139 X1146
SGTC_654 1124-0271 80.9 µM -0.349279072438153 0.369783137545551 no 2140 0.363439904041795 3041 5403748
SGTC_3226 9131256 49.47 µM -0.350598956385039 0.369305690834709 no 2141 0.362944619792437 3059 17178073
SGTC_3246 9135460 32.98 µM -0.351673948294362 0.368916978725521 no 2142 0.362541400148834 3099 41446951
SGTC_2122 5258151 111.688 µM -0.352238062266445 0.368713051317757 no 2143 0.362329867099143 3030 2173356
SGTC_3129 9127257 49.47 µM -0.352314844656277 0.368685297312369 no 2144 0.362301078270097 3026 837894
SGTC_785 1270-0111 65.3 µM -0.352406573758728 0.368652141518866 no 2145 0.362266686333812 2987 6741994
SGTC_2091 4-phenylthiadiazole 200 µM -0.353789231195172 0.36815249389538 no 2146 0.361748422244279 3024 270010
SGTC_2072 5231554 129 µM -0.355223907562297 0.367634283987324 no 2147 0.361210927752246 3151 789545
SGTC_3147 9097027 49.47 µM -0.3563903503828 0.367213138431962 no 2148 0.360774127442731 3036 25236841
SGTC_303 1348-1668 34.2 µM -0.357066021269797 0.366969259676209 no 2149 0.360521190541633 3070 5380509
SGTC_570 0987-0065 62.6 µM -0.357327830224592 0.366874775959417 no 2150 0.360423198947579 2988 3104428
SGTC_1210 3013-0140 750 nM -0.357365544429342 0.36686116601889 no 2151 0.360409083779823 3151 905973
SGTC_3336 9143619 71.43 µM -0.357577306961053 0.36678475029565 no 2152 0.360329831667328 3155 45595730
SGTC_3032 9089427 49.47 µM -0.358145420522502 0.366579769347149 no 2153 0.360117244860408 3126 17173707
SGTC_481 bay k-8644 50 µM -0.359019806273469 0.36626435675103 no 2154 0.359790136224814 3041 2303 A calcium channel antagonist.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.360242994869175 0.365823273934751 no 2155 0.359332712398212 3160 521171
SGTC_784 4579-0127 173 µM -0.361005025575743 0.365548574633151 no 2156 0.359047845097705 3236 1948547
SGTC_2182 6325192 200 µM -0.363862603286918 0.36451908079652 no 2157 0.357980305725406 3129 736248
SGTC_2568 diosmetin 100 µM -0.364798419748982 0.364182147937692 no 2158 0.357630942394287 3208 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3174 9107204 49.47 µM -0.364979067275783 0.364117119389118 no 2159 0.357563515946929 3173 3938802
SGTC_396 dithiazanine 1.25 µM -0.36523514858886 0.364024943286107 no 2160 0.357467941557846 3048 10578 An antihelmenthic.
SGTC_2876 9059903 25.97 µM -0.365962506285063 0.363763174840954 no 2161 0.357196526678665 3122 6916095
SGTC_3277 9138724 49.47 µM -0.366291331655664 0.363644854881478 no 2162 0.357073848582073 3083 15943418
SGTC_675 1309-0189 238 µM -0.367058246519896 0.36336894942468 no 2163 0.356787785589042 3094 4246530
SGTC_1624 st003710 6.25 µM -0.371299347720689 0.36184445302407 no 2164 0.355207291867753 3174 24207033
SGTC_2037 5169046 200 µM -0.372323856312884 0.361476513003691 no 2165 0.354825869304756 3174 5718022
SGTC_2889 9059656 51.95 µM -0.374283400264694 0.36077312318102 no 2166 0.354096740373244 3155 3949838
SGTC_578 3460-0051 92 µM -0.375206294320049 0.360442007833778 no 2167 0.353753524701216 3186 2876744
SGTC_2833 9001315 45.46 µM -0.375364132199683 0.36038538932945 no 2168 0.353694838161261 3022 2989378
SGTC_3193 9111931 49.47 µM -0.377787597640027 0.359516445732288 no 2169 0.352794193893113 3044 17087244
SGTC_1224 0823-0416 294 µM -0.379244916256535 0.358994267281383 no 2170 0.352253000020321 3201 3598164
SGTC_1785 bathophenanthroline 24 µM -0.379449526532938 0.358920973506106 no 2171 0.352177039298604 3084 72812 An iron chelator.
SGTC_2000 st075254 36.4 µM -0.379619924882013 0.35885993880368 no 2172 0.352113784114424 3087 17234175
SGTC_2061 5245884 80.95 µM -0.382162784663582 0.357949544971352 no 2173 0.351170312056233 3058 573863
SGTC_864 0469-0573 172 µM -0.382768950750618 0.35773264454947 no 2174 0.350945542562837 3090 689425
SGTC_2149 5554786 194.827 µM -0.382829014409739 0.357711154865614 no 2175 0.350923273488359 3083 745063 YPR165W RHO1
SGTC_1147 3809-1045 12.3 µM -0.383930186121946 0.357317255667986 no 2176 0.350515096224809 3091 325925
SGTC_1753 st043925 64 µM -0.384325975511176 0.357175715290758 no 2177 0.35036842896324 3180 670181
SGTC_3272 9137413 49.47 µM -0.384823295239089 0.356997893962929 no 2178 0.350184169338352 3049 17614870
SGTC_1 0258-0098 57.368 µM -0.385678763630286 0.356692085913855 no 2179 0.349867296228968 3118 6790032 YDR047W HEM12
SGTC_2383 9036125 200 µM -0.390288654904415 0.355045757401376 no 2180 0.34816155576319 3078 79580
SGTC_486 niguldipine 82 µM -0.390644185179187 0.354918898891631 no 2181 0.34803013030192 3087 1236 A calcium channel blocker.
SGTC_341 1486-1430 230 µM -0.391112711873258 0.354751746137159 no 2182 0.347856962417158 3032 2054753 YPL210C SRP72
SGTC_2988 9073640 71.4286 µM -0.391351974379823 0.354666397030236 no 2183 0.347768543017861 3292 9102229
SGTC_1390 3413-2614 145 µM -0.391679411497912 0.354549606326534 no 2184 0.347647552131321 3144 3421432
SGTC_1200 1643-0193 18.4 µM -0.393001798930833 0.354078074647696 no 2185 0.347159076359518 3209 5403974
SGTC_1618 st003135 44.5 µM -0.394648610469565 0.353491173879399 no 2186 0.346551116705024 3174 1270615
SGTC_1218 1348-1416 30.7 µM -0.396261028750883 0.352916867675422 no 2187 0.345956236834214 3087 6787668
SGTC_1638 st008370 60.6 µM -0.397422369413426 0.352503432326132 no 2188 0.345528011254262 3156 24207134
SGTC_2368 9071271 200 µM -0.399069386835458 0.351917395630506 no 2189 0.344921039176182 3126 27209959
SGTC_3017 9080681 49.47 µM -0.399467143400804 0.351775919764862 no 2190 0.344774514469463 3177 16451914
SGTC_2083 5306046 65.942 µM -0.400157942563366 0.351530261955714 no 2191 0.344520094697271 3137 539837
SGTC_961 1252-1571 372 µM -0.400680028705696 0.351344641973563 no 2192 0.344327858199527 3277 6813498
SGTC_1978 st071761 42 µM -0.402562309306271 0.350675719609026 no 2193 0.343635120818833 3114 5147680
SGTC_256 clotrimazole 625 nM -0.402762452656298 0.350604620111577 no 2194 0.343561492712762 3175 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1852 st056254 31.4 µM -0.403355898743693 0.350393833391894 no 2195 0.343343212530688 3103 442583
SGTC_2208 7283366 200 µM -0.403987714372415 0.350169468785428 no 2196 0.343110876759711 3200 898663
SGTC_3083 9117465 49.47 µM -0.406245295646781 0.349368204770391 no 2197 0.342281187798897 3200 16420915
SGTC_2205 7238770 200 µM -0.407467534801235 0.348934685536843 no 2198 0.341832316964888 3238 279867
SGTC_444 curcumin 90.4 µM -0.40816067884547 0.348688919996533 no 2199 0.341577857102765 3238 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2900 5328528 85.29 µM -0.408560562304382 0.34854716365609 no 2200 0.341431088764289 3127 795359
SGTC_2693 st077581 40.7 µM -0.409898995596183 0.348072850843877 no 2201 0.340940021102498 3245 25238761
SGTC_2904 7225135 42.03 µM -0.412733486314772 0.34706915159838 no 2202 0.339900943972747 3243 4446116
SGTC_689 0833-0039 98 µM -0.414366646396738 0.346491332344539 no 2203 0.339302805872884 3174 5374726
SGTC_2593 nobiletin 86.24 µM -0.415550173457478 0.346072818257691 no 2204 0.338869596794618 3180 72344 An anti-infammatory.
SGTC_1123 mangostin 811.285 nM -0.416627066205593 0.345692175049523 no 2205 0.338475604384545 3181 5281650 An antioxidant.
SGTC_2636 apigenin dimethyl ether 100 µM -0.416877568950436 0.345603653598973 no 2206 0.338383980673219 3275 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3225 9130819 49.47 µM -0.418018418176009 0.345200612641138 no 2207 0.337966825526484 3258 4547121
SGTC_743 1275-0778 158 µM -0.418455027628915 0.345046412998367 no 2208 0.337807230491227 3219 2849257 YMR203W TOM40
SGTC_1133 3473-0247 50 µM -0.418830190357646 0.344913935366045 no 2209 0.337670119531909 3150 711311
SGTC_2328 6201408 200 µM -0.419971953615169 0.344510872429202 no 2210 0.337252971206066 3235 2890418
SGTC_1018 4259-0013 28.1 µM -0.42059427820954 0.344291254951915 no 2211 0.337025686301373 3250 6801262
SGTC_2159 5658611 73.75 µM -0.420831193278612 0.344207661748293 no 2212 0.336939175992857 3264 793844
SGTC_1655 st012546 55.1 µM -0.422308215298055 0.343686680520145 no 2213 0.336400031249772 3216 720985 YLR208W SEC13
SGTC_3230 9131665 49.47 µM -0.423493379532136 0.343268859077502 no 2214 0.335967663925493 3177 15943720
SGTC_797 k781-0471 270 µM -0.425112140556688 0.342698485567219 no 2215 0.335377464023096 3145 23738129
SGTC_386 1509-0011 3.07 µM -0.425135024391611 0.342690424970939 no 2216 0.335369123489461 3158 3107280
SGTC_24 0417-1663 219 µM -0.425772089954844 0.342466053919934 no 2217 0.33513696305429 3232 4329390
SGTC_2803 7707263 71.43 µM -0.426144443060561 0.342334938898528 no 2218 0.335001298699925 3112 2199229
SGTC_1817 st052116 64.4 µM -0.429273286135778 0.341233945488065 no 2219 0.333862177590095 3287 4361398
SGTC_2802 7925815 54.55 µM -0.430411400751049 0.340833794237691 no 2220 0.333448201785665 3139 1262923
SGTC_1088 bifonazole 369 nM -0.43161857689234 0.340409557188215 no 2221 0.333009327239394 3231 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1786 berberine 21.6 µM -0.433687309900203 0.339683013454432 no 2222 0.332257761515352 3210 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2684 capsaicin 100 µM -0.433893914366872 0.339610486145854 no 2223 0.332182739583603 3269 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1893 st059353 36.1 µM -0.434458599651416 0.339412286932239 no 2224 0.331977726150897 3222 3112488
SGTC_1934 st074720 32.6 µM -0.435125373144803 0.339178312904282 no 2225 0.331735713545269 3130 17250992
SGTC_732 3970-1727 52.7 µM -0.435833797819361 0.338929791209327 no 2226 0.331478660117907 3258 1275699
SGTC_2770 toltrazuril 17.5 µM -0.435945654109989 0.338890557428891 no 2227 0.331438080071915 3280 68591 Kills coccidiodes.
SGTC_3242 9133940 49.47 µM -0.437889670149542 0.338208970004176 no 2228 0.33073313206331 3287 17248444
SGTC_2884 9058502 51.95 µM -0.44141927437723 0.336972818400013 no 2229 0.329454745521745 3274 6471554
SGTC_2673 kobusone 100 µM -0.441598712502132 0.336910021753354 no 2230 0.329389807921635 3220 6710676 An epoxy ketone and protein crosslinker.
SGTC_345 1362-0200 395 µM -0.441651340367506 0.336891604826707 no 2231 0.32937076318304 3192 1419823
SGTC_744 1594-0068 283 µM -0.441742027621146 0.336859870075581 no 2232 0.329337946720367 3177 668392
SGTC_344 k064-0035 6.43 µM -0.4434493110667 0.336262646786422 no 2233 0.328720387687429 3159 5088750
SGTC_3035 9091303 49.47 µM -0.444901870843878 0.335754853216369 no 2234 0.328195335290656 3241 25237002
SGTC_1646 st011709 75.6 µM -0.445247353740995 0.335634121557879 no 2235 0.328070504530933 3283 5757843
SGTC_923 1900-2434 73.3 µM -0.445623979668665 0.335502526056422 no 2236 0.327934442967443 3169 5910570
SGTC_2333 9017922 200 µM -0.446412530785476 0.33522706662751 no 2237 0.327649641441844 3294 3163164
SGTC_3319 9138450 16.7555 µM -0.447176056057435 0.334960433715503 no 2238 0.327373974032273 3167 2029690
SGTC_3049 9092223 49.47 µM -0.447936026292872 0.334695124846904 no 2239 0.327099683601548 3261 8623917
SGTC_2662 daunorubicin 22.37 µM -0.448098941436658 0.334638261206138 no 2240 0.327040895992162 3207 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1324 1418-0026 34.4 µM -0.448583423206063 0.33446918087861 no 2241 0.326866097060038 3266 1372513
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.449836377512611 0.33403206541908 no 2242 0.326414212777811 3195 2333 A French combination drug.
SGTC_1354 1498-1681 81 µM -0.450216142452305 0.333899622062154 no 2243 0.326277298896277 3279 5754243
SGTC_402 epigallocatechin gallate 10 µM -0.450729903504247 0.33372048037014 no 2244 0.326092113629929 3197 65064 An antioxidant.
SGTC_2032 5185112 25.99 µM -0.45083730470385 0.333683035778694 no 2245 0.326053406265044 3205 5718189
SGTC_456 gingerol 170 µM -0.450999051522678 0.333626647136465 no 2246 0.325995116289632 3368 442793 A herb.
SGTC_543 3844-1095 191 µM -0.452021485342421 0.333270290316406 no 2247 0.325626752196442 3274 4230703
SGTC_2295 7971645 200 µM -0.452673799027794 0.333043012941124 no 2248 0.325391824494203 3206 2978226 YKL099C UTP11
SGTC_2814 7977482 42.97 µM -0.452790626872827 0.333002314569776 no 2249 0.325349756817175 3319 6456762
SGTC_2772 vinpocetine 57.06 µM -0.453030198863789 0.33291886296613 no 2250 0.325263498066824 3383 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3053 9095903 49.47 µM -0.45440433548998 0.332440361358824 no 2251 0.324768916230864 3292 17174018
SGTC_260 nsc-65238 3.989 µM -0.454495240896834 0.332408715911626 no 2252 0.324736208265339 3286 3246252
SGTC_2266 7929956 200 µM -0.454545401174752 0.332391254926741 no 2253 0.324718161065439 3260 2967153
SGTC_2759 disulfiram 3.38 µM -0.455014394438157 0.332228014179643 no 2254 0.324549441579995 3162 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_529 4076-0302 30.3 µM -0.457250769555816 0.331450045552714 no 2255 0.323745405279038 3205 5816522
SGTC_1644 st010134 20.9 µM -0.457394007149383 0.33140024216602 no 2256 0.323693935525373 3312 3818134
SGTC_1397 3532-0190 20.1 µM -0.458643503101754 0.330965921772159 no 2257 0.323245095588462 3118 5322280
SGTC_2936 9038235 15.59 µM -0.459427008382365 0.330693694049242 no 2258 0.322963778470934 3204 4749415
SGTC_1028 k015-0029 4.8 µM -0.461073624572515 0.330121871672223 no 2259 0.322372892020245 3201 4588309
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.461237258318992 0.330065068028343 no 2260 0.322314196701636 3321 5282362
SGTC_1351 1496-0003 46.5 µM -0.461263184005833 0.330056068572584 no 2261 0.32230489758109 3333 3891978
SGTC_1841 st054148 70 µM -0.461750379167795 0.329886969212336 no 2262 0.322130169317026 3268 675442
SGTC_276 colchicine 750 µM -0.461908816940854 0.329831984926725 no 2263 0.322073355469279 3349 2833 A microtubule depolymerizer.
SGTC_1459 k035-0031 35.7 µM -0.462005044913187 0.329798591741061 no 2264 0.322038851324629 3164 3877128 YMR208W ERG12
SGTC_2883 9059145 45.46 µM -0.4641453974816 0.32905619421763 no 2265 0.321271789171121 3165 16476510
SGTC_1430 4049-0248 69.1 µM -0.46418107153757 0.329043826101187 no 2266 0.32125901070508 3307 22774488
SGTC_560 2332-1943 155 µM -0.465755347498405 0.328498214624492 no 2267 0.320695315095726 3295 21177716
SGTC_297 0986-0032 24 µM -0.470490439628586 0.326859336366514 no 2268 0.319002331524289 3235 2847425
SGTC_3224 9130643 49.47 µM -0.471739834436722 0.326427458909667 no 2269 0.318556250216624 3403 17644395
SGTC_606 k015-0008 38.6 µM -0.472385667777053 0.326204305281607 no 2270 0.318325766246476 3350 1970475
SGTC_2972 9093619 59.92 µM -0.472425774361208 0.326190449376823 no 2271 0.318311455390645 3177 25236256
SGTC_1503 4585-0012 61.3 µM -0.473219161821338 0.325916401547262 no 2272 0.318028414152178 3372 2922052
SGTC_1710 st031758 61.5 µM -0.475343939690843 0.325182935048638 no 2273 0.317270922611272 3388 5394341
SGTC_524 r073-0010 27.8 µM -0.475353195963674 0.325179741291633 no 2274 0.317267624385094 3186 2772106
SGTC_893 0958-0369 48.9 µM -0.475558798903927 0.325108803972313 no 2275 0.317194366997525 3333 6819948
SGTC_2825 7998094 58.44 µM -0.475921380415264 0.324983721205818 no 2276 0.317065194790283 3252 2987815
SGTC_1668 st014914 51.6 µM -0.476088652125658 0.324926022737574 no 2277 0.31700561058203 3334 2839556
SGTC_2245 6637752 200 µM -0.476159471721833 0.324901595590999 no 2278 0.316980385214152 3307 681890
SGTC_1281 0884-0031 11.8 µM -0.478394931697843 0.324130926496662 no 2279 0.316184570144684 3265 1548255
SGTC_1119 parthenolide 318.541 nM -0.478400326025424 0.3241290677255 no 2280 0.316182650812558 3407 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2669 eugenol 100 µM -0.479739144518373 0.323667874864301 no 2281 0.315706444930551 3288 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_447 ml7 120 µM -0.480161792497876 0.32352233831819 no 2282 0.315556176254163 3342 4216 Selective myosin light chain kinase inhibitor.
SGTC_557 1315-0110 16.2 µM -0.480813909361457 0.323297838360305 no 2283 0.315324381812822 3229 6833801
SGTC_712 r015-0009 80.6 µM -0.482412688499563 0.322747709559914 no 2284 0.314756404612053 3337 6813872 YLR060W FRS1
SGTC_429 1112-0049 25.5 µM -0.48265182142713 0.322665458883128 no 2285 0.314671488627044 3189 2836170
SGTC_1215 3852-0577 11.2 µM -0.483207864695619 0.322474239241165 no 2286 0.314474075830074 3384 2884876
SGTC_1126 isoteolin 1.0172 µM -0.48601324555132 0.321510204021364 no 2287 0.313478887389251 3241 133323
SGTC_198 3454-2873 16.191 µM -0.487343850107562 0.321053377299316 no 2288 0.313007338833818 3276 710957
SGTC_1125 tnp00248 1.32998 µM -0.487658012153978 0.320945557821639 no 2289 0.312896048566508 3387 24207736
SGTC_1522 st012842 45.6 µM -0.488336795694331 0.320712652892535 no 2290 0.312655651258659 3235 3491067 YOR116C RPO31
SGTC_110 0850-0284 111.64 µM -0.489818097956103 0.320204631981863 no 2291 0.312131311478702 3197 3906265
SGTC_1449 4112-4002 201 µM -0.48991693041069 0.320170748814512 no 2292 0.312096341063843 3303 2059539
SGTC_1554 st069299 38.7 µM -0.491297133481223 0.31969772449653 no 2293 0.311608153493962 3332 24207999
SGTC_215 1287-0124 461.5 µM -0.492637880630099 0.319238503185569 no 2294 0.311134238623506 3310 5560863
SGTC_2775 cyproheptadine 69.59 µM -0.493463691502556 0.318955791365306 no 2295 0.31084249433748 3382 2913 A selective serotonin reuptake inhibitor.
SGTC_2463 5473429 200 µM -0.494807453612172 0.318495986897291 no 2296 0.310368021234468 3293 5399405
SGTC_123 0083-0120 66.675 µM -0.49658812359856 0.317887113104019 no 2297 0.309739764944888 3284 16001701
SGTC_2976 9009005 19.48 µM -0.49689474354607 0.317782318554276 no 2298 0.309631639242358 3402 2993148
SGTC_1685 st024049 53.0905 µM -0.497176111608574 0.317686167268146 no 2299 0.309532432795625 3328 1941139
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.497510215724778 0.317572010574336 no 2300 0.309414650375914 3569 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2307 7538926 6.34 µM -0.498059109363147 0.317384502254837 no 2301 0.309221190262706 3287 96582
SGTC_3149 9097855 49.47 µM -0.498755953350523 0.317146519914436 no 2302 0.308975660550023 3369 25236625 YMR079W SEC14
SGTC_3194 9111903 49.47 µM -0.499085380223058 0.317034042165227 no 2303 0.308859618231179 3423 17087251
SGTC_969 1313-0238 134 µM -0.499596180013502 0.316859670845479 no 2304 0.308679724091463 3255 5212874
SGTC_340 k038-0059 454 µM -0.499792480904255 0.316792670582888 no 2305 0.308610602794197 3353 23733424
SGTC_682 0kpi-0099 17 µM -0.49984424893951 0.316775002423499 no 2306 0.308592375408961 3360 1714895 YML126C ERG13
SGTC_1706 st031321 9.9705 µM -0.500241503857841 0.316639435310692 no 2307 0.308452518725456 3370 6103185
SGTC_1262 0737-0114 49.6 µM -0.500724929421051 0.316474494843543 no 2308 0.308282362483821 3423 765919
SGTC_2319 6033012 152.6 µM -0.500927304659217 0.31640545706195 no 2309 0.308211142627916 3236 847246
SGTC_2338 7999974 200 µM -0.502429731125253 0.315893123245472 no 2310 0.307682634886611 3322 315925
SGTC_1250 0485-0349 40.2 µM -0.502628424489316 0.315825394405648 no 2311 0.307612770468427 3252 6842794 YDL195W SEC31
SGTC_403 arphamenine a 50 µM -0.502956888400518 0.315713444087578 no 2312 0.307497291524661 3328 5487158 An arginine aminopeptidase inhibitor.
SGTC_926 2268-1401 59.4 µM -0.504343146043379 0.315241152388739 no 2313 0.307010131438007 3366 2931578
SGTC_134 0269-0018 6.916 µM -0.505950170014946 0.314694024323546 no 2314 0.306445815597202 3318 4378915
SGTC_2450 5739737 12.93 µM -0.506813807550035 0.314400157801215 no 2315 0.306142733642769 3376 2262825
SGTC_2738 aclarubicin 5.55 µM -0.509567396801883 0.313463990637895 no 2316 0.305177284997641 3290 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1030 k029-0042 36.7 µM -0.509861516095443 0.313364066611721 no 2317 0.305074242397532 3336 6080581
SGTC_580 1123-0028 41 µM -0.510654581061009 0.313094699172031 no 2318 0.304796474753488 3397 1677248 YPR107C YTH1
SGTC_3099 9120367 49.47 µM -0.511024711399035 0.312969017159188 no 2319 0.304666876656634 3378 24824940
SGTC_484 loperamide 105 µM -0.511144505406516 0.312928344380652 no 2320 0.304624937018751 3313 3955 An opioid-receptor agonist.
SGTC_2730 imipramine 71.33 µM -0.512600855196457 0.31243406285761 no 2321 0.304115277434289 3413 3696 A tricyclic antidepressant.
SGTC_1772 st048439 82.2 µM -0.514319701337176 0.311851124668879 no 2322 0.303514244853675 3358 2927068 YDL195W SEC31
SGTC_2228 7354201 200 µM -0.51487414416818 0.311663188520647 no 2323 0.303320484876439 3335 753451
SGTC_1163 k060-0048 49.9 µM -0.515638350717812 0.311404230422024 no 2324 0.303053509867589 3362 6809982
SGTC_2867 9039098 71.43 µM -0.518129496326874 0.310560732043978 no 2325 0.302183960812559 3340 6463460
SGTC_2243 6634756 200 µM -0.518546581638475 0.310419604673852 no 2326 0.302038484236377 3476 885676
SGTC_971 1315-0384 26.7 µM -0.52041022883024 0.309789351497263 no 2327 0.301388841122255 3330 6769120
SGTC_1310 1188-0297 994 nM -0.520711108200689 0.309687651644855 no 2328 0.301284017496713 3323 1588352
SGTC_2414 st077232 92.9 µM -0.520829378753 0.309647679154363 no 2329 0.301242817611952 3228 729801
SGTC_2822 7994718 71.43 µM -0.521032250238053 0.309579118906099 no 2330 0.301172152660853 3343 1018011
SGTC_581 0958-0271 211 µM -0.521035432012118 0.309578043680989 no 2331 0.301171044432948 3333 4591145
SGTC_995 3931-2021 34.6 µM -0.521183111557564 0.309528139745075 no 2332 0.301119608926425 3360 730143
SGTC_2131 toluylene red 5.2905 µM -0.52193241153507 0.309274990100342 no 2333 0.300858695250822 3318 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1442 4112-3290 3 µM -0.522297458374856 0.309151692465142 no 2334 0.300731619276114 3340 704353
SGTC_742 0kpi-0133 140 µM -0.522566812073891 0.309060729770924 no 2335 0.300637870446668 3420 2728852
SGTC_1049 3226-0134 66 µM -0.524856000105674 0.308288127358011 no 2336 0.29984164931386 3402 5702385
SGTC_772 k072-0172 35.3 µM -0.53047489272334 0.306395349744005 no 2337 0.297891356139164 3328 5861980
SGTC_213 1246-0773 967 nM -0.531741318154884 0.305969452218471 no 2338 0.297452585375121 3363 6251622
SGTC_1813 st051246 8.6015 µM -0.533595956614211 0.305346212517531 no 2339 0.296810553160526 3377 5291959
SGTC_1375 2910-0797 186 µM -0.533866176283044 0.305255453898011 no 2340 0.296717062433475 3336 742508
SGTC_678 1218-2179 85.9 µM -0.533908567674093 0.305241216997257 no 2341 0.296702397063888 3387 6820081 YOR116C RPO31
SGTC_1889 st059080 5.18 µM -0.534397272666797 0.305077109566382 no 2342 0.29653335276416 3456 176925 Isolated from Daphnopsis sellowiana.
SGTC_75 0159-0059 199.013 µM -0.535153034144428 0.304823401574396 no 2343 0.296272019873423 3567 5377270
SGTC_1674 st016616 23.6 µM -0.535586395077302 0.304677965274213 no 2344 0.296122216732314 3309 625830
SGTC_2806 7952793 58.44 µM -0.535939692154997 0.304559421309388 no 2345 0.296000115591236 3411 2972490
SGTC_2012 4023501 200 µM -0.536284051922253 0.30444389588712 no 2346 0.295881125474203 3343 3477460
SGTC_1625 st003711 30.1 µM -0.537438302554392 0.304056811531449 no 2347 0.295482445879094 3488 24207034 YER133W GLC7
SGTC_2452 5863136 48.41 µM -0.537562514794522 0.304015169343706 no 2348 0.295439557545786 3373 2184096
SGTC_432 NS 1619 61.3 µM -0.537867908831214 0.303912796720126 no 2349 0.29533412245547 3442 4552 A K+/calcium channel activator.
SGTC_3154 9100113 49.47 µM -0.538315204740301 0.303762884232948 no 2350 0.295179728025173 3333 25237525
SGTC_1152 3909-8331 15.9 µM -0.539755275082357 0.30328046487642 no 2351 0.294682907347943 3346 16001939
SGTC_750 4073-0104 132 µM -0.540995060898105 0.302865414812611 no 2352 0.294255493529056 3347 22330957
SGTC_659 k018-0002 107 µM -0.541687147519277 0.302633831744771 no 2353 0.294017022583814 3447 6797879 YHR007C ERG11
SGTC_1905 st060207 84.5 µM -0.542139343666631 0.302482562674665 no 2354 0.293861258509568 3348 1948547
SGTC_409 arachidonic acid 100 µM -0.542734127663441 0.30228364662295 no 2355 0.293656436581239 3364 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_311 1315-0136 58 µM -0.54312050475549 0.302154460402476 no 2356 0.293523417811774 3480 6759207
SGTC_3077 9117319 49.47 µM -0.54463029446042 0.301649895957445 no 2357 0.293003907413319 3438 17154678
SGTC_917 harmaline 728.087 nM -0.545492867558942 0.301361798378216 no 2358 0.292707292331128 3381 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3343 9148379 18.9835 µM -0.545815769606598 0.301253981656927 no 2359 0.292596291114125 3479 1955036
SGTC_2193 5925765 200 µM -0.546226215059754 0.30111695934876 no 2360 0.292455224101987 3436 877370
SGTC_2051 5263410 176 µM -0.546605381051255 0.30099040427595 no 2361 0.292324935704975 3495 227584
SGTC_1486 3970-0793 4.53 µM -0.549225598367133 0.300116504756668 no 2362 0.291425319608377 3446 2844330
SGTC_3104 9120930 49.47 µM -0.550198751499729 0.299792229501798 no 2363 0.291091529908583 3462 17014836
SGTC_2702 st077768 96.8 µM -0.551150046790551 0.299475391183197 no 2364 0.290765410103689 3400 6484119
SGTC_6 0844-0013 19.835 µM -0.551293214438736 0.299427720924914 no 2365 0.290716344653171 3508 1584900
SGTC_1547 harmine 94.2 µM -0.552686468086723 0.298963991693909 no 2366 0.290239060480705 3480 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_788 1182-0090 188 µM -0.553125874065895 0.298817807909809 no 2367 0.290088610208605 3519 5715185
SGTC_47 0149-0135 24.25 µM -0.553505304822738 0.2986916031238 no 2368 0.289958724550141 3357 5239155
SGTC_592 k241-0073 46.5 µM -0.554904621209077 0.298226377557543 no 2369 0.28947995042047 3476 4230158
SGTC_3115 9123671 49.47 µM -0.556359121940754 0.29774315512438 no 2370 0.288982688943434 3505 3286988
SGTC_2928 9011484 9.79 µM -0.557851370393097 0.297247763479267 no 2371 0.288472940393355 3445 2994751
SGTC_1298 1079-1278 263 µM -0.5578836913411 0.297237037848055 no 2372 0.288461904324 3441 2840950
SGTC_766 1391-0721 126 µM -0.55836845911838 0.297076190017607 no 2373 0.288296403020873 3469 1020919 YIL115C NUP159
SGTC_2907 7721985 69.9 µM -0.558591072690505 0.2970023393087 no 2374 0.288220417025735 3411 3267881
SGTC_392 N-ethylmaleimide 8.33 µM -0.558784985188003 0.296938016852214 no 2375 0.28815423543608 3372 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1578 josamycin 24.2 µM -0.561347854691103 0.296088490271861 no 2376 0.287280212261386 3382 5282165 A P450 substrate.
SGTC_711 k292-0785 179 µM -0.561967682918447 0.295883200469487 no 2377 0.287069018900066 3465 4146315
SGTC_2393 9031399 185.94 µM -0.562177147519769 0.295813839664059 no 2378 0.286997664891561 3512 1526623 YDL150W RPC53
SGTC_17 0960-0276 49.807 µM -0.562601067425196 0.295673488322093 no 2379 0.286853282504946 3456 6821114
SGTC_2306 7482397 179.52 µM -0.563510766270044 0.29537240871084 no 2380 0.286543565477628 3489 891448
SGTC_2351 9026858 72.31 µM -0.564155216348612 0.29515920288405 no 2381 0.286324251367349 3376 1409300
SGTC_569 4130-2812 160 µM -0.566226438657458 0.294474452983497 no 2382 0.285619929669641 3414 743552
SGTC_336 4111-0029 111 µM -0.56706511093492 0.294197395095162 no 2383 0.285334972824252 3413 3131175
SGTC_2119 5528445 120.635 µM -0.567791398877352 0.293957561058288 no 2384 0.285088310426548 3486 791935
SGTC_856 0433-0016 11.3 µM -0.568592493161184 0.293693129453653 no 2385 0.284816360201684 3451 3911780
SGTC_1447 4239-0816 81.9 µM -0.569122662525525 0.293518187475129 no 2386 0.284636449882893 3399 1341554
SGTC_1716 st033144 30.6155 µM -0.570469562843736 0.293073962896893 no 2387 0.284179630183768 3529 674617
SGTC_1076 itraconazole 331 nM -0.571291428863779 0.292803054488615 no 2388 0.283901055394443 3475 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3182 9108849 49.47 µM -0.573154859195718 0.29218925044938 no 2389 0.283269922759267 3506 17133045
SGTC_858 0438-0351 2.77 µM -0.576036071899502 0.291241374600119 no 2390 0.282295400049404 3447 2799119
SGTC_2016 5121758 140 µM -0.576052784904847 0.291235880461362 no 2391 0.282289751859886 3479 2795203
SGTC_596 1155-0152 116 µM -0.577414663375173 0.290788346939683 no 2392 0.281829685483836 3482 280313
SGTC_1775 st081588 35.1725 µM -0.578098439792767 0.290563769153018 no 2393 0.281598830179364 3515 1426443 YGL099W LSG1
SGTC_1438 4092-1045 4 µM -0.578159027630435 0.290543873752558 no 2394 0.281578379027134 3464 1351342
SGTC_1565 sinapyl alcohol 95.1 µM -0.578607503972066 0.29039662612854 no 2395 0.281427020134334 3465 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2121 5257820 149.641 µM -0.578665824398093 0.290377480430233 no 2396 0.281407340119118 3523 791256
SGTC_451 chloral hydrate 100 µM -0.578933088220566 0.290289749391585 no 2397 0.281317161412632 3506 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3299 9121982 43.1275 µM -0.581051761228203 0.289594721258781 no 2398 0.280602784316902 3438 17594604 YPL160W CDC60
SGTC_2956 9076196 2.52 µM -0.581169014932418 0.289556279147775 no 2399 0.280563274197593 3541 16423868
SGTC_1520 flindersine 88 µM -0.582147373150212 0.28923561381097 no 2400 0.280233709003539 3570 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1066 ketoconazole 628 nM -0.583046016275744 0.288941222943799 no 2401 0.27993116159803 3526 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_728 3030-5151 22.5 µM -0.583168151303943 0.28890122302231 no 2402 0.279890054461197 3507 3125388
SGTC_1468 k284-1086 134 µM -0.583495077340109 0.288794165697859 no 2403 0.279780034970974 3508 15996457
SGTC_1491 4138-0063 26.5 µM -0.584572079394585 0.288441615778574 no 2404 0.279417743009791 3484 23883227
SGTC_2594 a-mangostin 100 µM -0.585293291080492 0.288205645083668 no 2405 0.279175262575442 3514 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1757 st041620 31.8375 µM -0.587335886046065 0.28753783032028 no 2406 0.278489072083133 3486 5289815
SGTC_2997 9067075 71.4286 µM -0.587559435017368 0.28746478669995 no 2407 0.278414022831269 3473 27209819
SGTC_891 0929-0073 133 µM -0.590975095905895 0.2863498277133 no 2408 0.277268553792589 3508 5603632
SGTC_2640 pentamidine 10.38 µM -0.591349048366516 0.286227884860176 no 2409 0.277143285992802 3502 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2950 9072895 21.46 µM -0.591849254032803 0.286064810430923 no 2410 0.276975768793467 3486 17332245
SGTC_1789 tunicamycin 25 nM -0.593298356107054 0.285592631135719 no 2411 0.276490749370615 3524 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1319 1306-0155 43.7 µM -0.594445649702824 0.285219057204278 no 2412 0.276107041884973 3533 3122360
SGTC_949 1165-0505 146 µM -0.595456088972002 0.284890237814118 no 2413 0.275769321393147 3481 6244267
SGTC_507 nimesulide 162 µM -0.595743762998565 0.284796655375879 no 2414 0.27567320885132 3569 4495 A COX2 inhibitor.
SGTC_2826 7992541 19.48 µM -0.59676838760794 0.284463456814594 no 2415 0.275331013295369 3566 2985066
SGTC_2389 9091542 195.52 µM -0.596912464602626 0.284416619230642 no 2416 0.27528291243514 3455 3626624 YOL127W RPL25
SGTC_1980 st071811 45.7 µM -0.597407713713436 0.284255648201257 no 2417 0.275117602473946 3572 4974850
SGTC_1372 2752-0194 270 µM -0.598101107570803 0.284030347303374 no 2418 0.274886235643699 3498 823334
SGTC_1821 st053465 65.6 µM -0.598774885803649 0.2838115018827 no 2419 0.274661505917764 3472 675086
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.599558094124245 0.283557214708818 no 2420 0.27440039117868 3517 61125 An anti-inflammatory.
SGTC_1054 3429-0080 167 µM -0.60035517193327 0.283298536615671 no 2421 0.274134778335839 3546 1162877
SGTC_352 k048-0007 5.11 µM -0.601289652512754 0.282995410973379 no 2422 0.27382354014593 3509 6811911
SGTC_384 k007-0144 5.16 µM -0.601464297076968 0.282938777261286 no 2423 0.273765392396234 3503 6824886
SGTC_2115 tiliquinol 12.7705 µM -0.603219368886962 0.282369945186199 no 2424 0.273181382110299 3464 71208 A bioactive hydroxyquinoline.
SGTC_2180 6301957 200 µM -0.603758342166738 0.282195370338582 no 2425 0.273002159609401 3511 845462
SGTC_1477 0139-0234 16 µM -0.604584154904626 0.281927988265394 no 2426 0.27272766872889 3520 620880
SGTC_908 3448-7491 47.7 µM -0.604622940372249 0.281915433288066 no 2427 0.27271478024266 3556 1203031
SGTC_2678 equilin 100 µM -0.606006155153821 0.281467858521453 no 2428 0.272255332969816 3559 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2059 5238311 157 µM -0.60674873387174 0.281227719567048 no 2429 0.2720088375205 3481 703021
SGTC_2931 9014674 55.67 µM -0.609754076464003 0.280256847973413 no 2430 0.271012363377372 3482 2996810
SGTC_3156 9099931 49.47 µM -0.610027718458603 0.280168529028846 no 2431 0.27092172310022 3502 18111053
SGTC_1231 0242-0792 125 µM -0.611368040956262 0.279736129994859 no 2432 0.270477977687323 3521 3707635
SGTC_321 4534-3890 65.3 µM -0.612255524611095 0.279449998786493 no 2433 0.270184355248134 3528 699746
SGTC_2279 7948423 32.93 µM -0.612558306200847 0.279352412321741 no 2434 0.270084216964301 3574 1247112
SGTC_918 glabranin 770.725 nM -0.614143384911407 0.278841812044294 no 2435 0.269560290616737 3525 124049 Also referred to as licorice root.
SGTC_2071 5230951 39.92 µM -0.614988719792942 0.278569690733706 no 2436 0.269281084971429 3596 1799272
SGTC_2991 9074669 71.4286 µM -0.615602877207466 0.278372068797181 no 2437 0.269078325933657 3555 17333109
SGTC_3169 9102970 49.47 µM -0.619083265327505 0.27725345129956 no 2438 0.267930753553988 3598 17027839
SGTC_2153 5569715 200 µM -0.619301860390008 0.277183266992388 no 2439 0.267858759557084 3551 2054701
SGTC_2424 5537928 59.2 µM -0.621953352662837 0.276332645307004 no 2440 0.266986270723325 3547 5382802
SGTC_3332 9141069 11.198 µM -0.623198638288493 0.275933589314575 no 2441 0.266576998223497 3528 17332883
SGTC_1348 1493-0373 93.8 µM -0.626997405078893 0.27471801328194 no 2442 0.265330468066124 3530 3010129
SGTC_679 0422-0091 41.4 µM -0.629080430076793 0.274052584146215 no 2443 0.264648200874005 3587 627384 YHR062C RPP1
SGTC_2983 9022671 12.99 µM -0.629526750620515 0.27391010926885 no 2444 0.264502130669467 3568 6405161
SGTC_904 1141-0088 396 µM -0.629814060117853 0.27381841342848 no 2445 0.264408122745365 3532 1378119
SGTC_2958 9077254 16.72 µM -0.63052287828145 0.273592256548502 no 2446 0.264176269564742 3603 16457351
SGTC_1750 st081859 2.357 µM -0.632567425209644 0.272940437773373 no 2447 0.263508082470402 3590 5291695
SGTC_3103 9120822 49.47 µM -0.632906679594644 0.272832355152788 no 2448 0.263397292793703 3657 17141819
SGTC_3081 9117243 49.47 µM -0.634500310347509 0.272324926640001 no 2449 0.262877182169357 3604 45595589
SGTC_1395 3486-0190 4.35 µM -0.637474007374563 0.271379326229725 no 2450 0.261908067771858 3619 6748079
SGTC_1276 0871-0068 94.2 µM -0.637759807733371 0.27128853135389 no 2451 0.261815023322847 3536 3414906
SGTC_3342 9147791 14.508 µM -0.637908098450623 0.271241427382335 no 2452 0.261766752850112 3550 1838168
SGTC_162 k030-0015 37.8 µM -0.639027582908543 0.270885959103854 no 2453 0.261402494125533 3597 1809920 YMR134W ERG29
SGTC_781 4335-2806 94.4 µM -0.639841818666449 0.270627562121189 no 2454 0.261137721077872 3633 845254
SGTC_2706 st078239 82.5 µM -0.640759666219172 0.270336431703802 no 2455 0.26083942091487 3601 15434492
SGTC_2116 5511452 16.8835 µM -0.640870643442781 0.270301241649666 no 2456 0.260803365234422 3571 870744
SGTC_2138 5575593 77.673 µM -0.641119930283846 0.27022220299297 no 2457 0.260722383130422 3570 762213
SGTC_181 1447-1644 8.07 µM -0.641151578165398 0.270212169571565 no 2458 0.260712103080134 3539 534600
SGTC_526 4469-0568 170 µM -0.641981387431413 0.269949159190059 no 2459 0.260442634028265 3592 2901964
SGTC_2401 5128683 200 µM -0.64273178047582 0.269711430373929 no 2460 0.260199077858881 3516 708373
SGTC_2274 7947094 46.08 µM -0.642913483388113 0.269653881623487 no 2461 0.260140119936987 3599 2971028
SGTC_2044 5102272 200 µM -0.643620106464055 0.26943013921618 no 2462 0.259910904401941 3576 592666
SGTC_2015 5119600 184 µM -0.64422558495978 0.269238496902972 no 2463 0.259714581219816 3583 2828786
SGTC_825 1988-2224 89.6 µM -0.644603763372714 0.269118832907016 no 2464 0.259591997723139 3593 1180859
SGTC_826 1683-5028 118 µM -0.644892645663278 0.269027442157091 no 2465 0.259498378976577 3586 722377
SGTC_3014 9081533 49.47 µM -0.645841304990185 0.268727434072347 no 2466 0.25919106746417 3588 21367265
SGTC_2807 7945238 51.95 µM -0.647543442671117 0.268189564430699 no 2467 0.25864014389706 3607 17148797
SGTC_612 0302-0167 22.4 µM -0.649295989586217 0.267636332253115 no 2468 0.258073538723959 3613 235821
SGTC_1665 st014639 11.4 µM -0.649366284163336 0.267614154140649 no 2469 0.258050825650984 3656 981133 YIL048W NEO1
SGTC_1490 4089-0339 670 nM -0.649783192454538 0.267482637590173 no 2470 0.257916138584081 3559 742542
SGTC_2253 7938677 135.83 µM -0.649852818354196 0.267460676804097 no 2471 0.257893648683031 3636 2301972
SGTC_3269 9137823 49.47 µM -0.650758255597869 0.267175174613725 no 2472 0.257601275570109 3529 17682936
SGTC_1506 4226-2149 212 µM -0.65092737736168 0.267121864246887 no 2473 0.257546683849631 3603 991114
SGTC_2470 5664817 21.68 µM -0.652948010932975 0.266485338124471 no 2474 0.256894897788601 3629 2859561
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.653932432639156 0.266175510527868 no 2475 0.256577668839415 3607 688761
SGTC_3046 9092212 49.47 µM -0.654244660071483 0.266077281121738 no 2476 0.256477096483957 3613 25236637
SGTC_2842 9000675 19.48 µM -0.659869746975785 0.264310731495897 no 2477 0.254668709948502 3569 2989072
SGTC_3337 9144342 33.5465 µM -0.661958606090521 0.263656252406958 no 2478 0.25399887528715 3605 17682949
SGTC_862 0452-0056 10.2 µM -0.662301140966385 0.263549008702412 no 2479 0.253889122882804 3569 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1720 st037298 9.481 µM -0.662397480369254 0.26351884996193 no 2480 0.253858259033767 3604 597396
SGTC_1410 3909-8106 77.9 µM -0.66249433025485 0.263488533191886 no 2481 0.253827233628722 3628 1039210
SGTC_1495 4469-0029 237 µM -0.664774518659623 0.262775284033354 no 2482 0.253097361485075 3607 793680
SGTC_2744 captopril 92.04 µM -0.665307166978642 0.262608812584541 no 2483 0.252927023741835 3594 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3340 9146634 11.102 µM -0.665423746005299 0.262572384713117 no 2484 0.25288975051631 3623 4907387
SGTC_2720 fluspirilene 36.88 µM -0.665425693641327 0.262571776150186 no 2485 0.252889127832999 3593 3396 An atypical antipsychotic.
SGTC_405 ebelactone b 50 µM -0.666571843440747 0.262213772738974 no 2486 0.252522829594728 3613 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1913 st060213 96.1 µM -0.666673995009681 0.262181877524361 no 2487 0.252490196528082 3650 688959
SGTC_3220 9131269 49.47 µM -0.667143783945676 0.262035218943532 no 2488 0.252340147626765 3659 17722206
SGTC_430 0958-0115 16.4 µM -0.667660298600925 0.261874022088945 no 2489 0.252175228967105 3597 6833180
SGTC_2893 9048488 25.97 µM -0.667778558259398 0.261837122092963 no 2490 0.252137477680726 3582 6467338
SGTC_591 4299-0174 154 µM -0.668604935249407 0.261579346079215 no 2491 0.251873761772217 3588 5509088
SGTC_2300 7976697 71.57 µM -0.668953923734248 0.261470523445744 no 2492 0.25176243526074 3556 2236109
SGTC_1264 0783-0040 158 µM -0.672542664541466 0.2603528216924 no 2493 0.250619144283763 3583 2855798
SGTC_2521 angolensin 13.4 µM -0.672678190255608 0.260310660926499 no 2494 0.250576022837458 3648 821428 A flavenoid.
SGTC_2607 solasodine 47.35 µM -0.672961623819409 0.26022249880184 no 2495 0.250485852916208 3645 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_272 doxorubicin 8.13 µM -0.673404571029343 0.260084750714086 no 2496 0.250344970682563 3650 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2281 7943571 200 µM -0.674869470246879 0.259629463042122 no 2497 0.2498793493176 3693 1244024
SGTC_362 0310-0100 9.03 µM -0.676061996868471 0.259259132252798 no 2498 0.249500641869345 3662 790235
SGTC_144 4161-2749 112.381 µM -0.67805027005822 0.258642295508641 no 2499 0.24886991010829 3566 797501 YMR168C CEP3
SGTC_3082 9117008 49.47 µM -0.67966837532561 0.258140860089185 no 2500 0.248357232310345 3662 41448529
SGTC_977 1348-1378 135 µM -0.680078015781766 0.2580139964125 no 2501 0.248227531865544 3648 X977
SGTC_2290 7904846 200 µM -0.680223633946027 0.257968906960444 no 2502 0.248181434916038 3667 2962154
SGTC_2330 7979373 200 µM -0.68118928730758 0.257670003899152 no 2503 0.247875862823157 3617 1863007
SGTC_2518 prenyletin 46.28 µM -0.681405196004398 0.25760319730697 no 2504 0.247807567989731 3585 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3227 9130768 49.47 µM -0.681436537182568 0.25759350044939 no 2505 0.247797655187291 3651 17720899
SGTC_476 mead acid 10 µM -0.682488276691682 0.257268205645709 no 2506 0.247465126601858 3664 5312531 An omega 9 fatty acid.
SGTC_1481 3346-2004 36 µM -0.684021897556424 0.256794251681908 no 2507 0.246980669224894 3658 2770522
SGTC_2256 7954252 200 µM -0.6848723428347 0.256531624007884 no 2508 0.246712239918142 3602 2972920
SGTC_2768 sulfasalazine 50.2 µM -0.686472679123147 0.256037800641321 no 2509 0.246207543507972 3694 5384001 An antioxidant and salicylic acid derivative.
SGTC_2332 7982454 138.89 µM -0.686571483575435 0.256007328343432 no 2510 0.246176401805082 3645 2981748
SGTC_914 3820-6779 408 µM -0.687446472733978 0.25573755537783 no 2511 0.245900710362696 3636 2893481
SGTC_945 3381-0768 11.3 µM -0.690032582927296 0.254941085239783 no 2512 0.245086848685656 3656 1126236 YIL048W NEO1
SGTC_735 3076-0345 636 µM -0.690120847573155 0.254913924422184 no 2513 0.245059096955924 3685 2888990
SGTC_280 3448-3607 3.04 µM -0.693242303742524 0.253954363782506 no 2514 0.244078752057547 3650 626179
SGTC_2236 dapsone 200 µM -0.693509428771046 0.253872335541539 no 2515 0.24399495539002 3684 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3130 9127414 49.47 µM -0.693680626390643 0.253819771818555 no 2516 0.24394125914927 3678 1494646
SGTC_2531 methyl deoxycholate 70.07 µM -0.695219757921326 0.253347460706703 no 2517 0.243458796032362 3652 16667744 Haematoxylin.
SGTC_37 0566-0070 1.56 µM -0.696155590763132 0.253060509023442 no 2518 0.243165697848741 3686 1626686
SGTC_2480 5767542 37.17 µM -0.698283470076665 0.252408680565925 no 2519 0.242499967325878 3671 2867358
SGTC_2688 kanamycin b 96.69 µM -0.698959256604081 0.252201853707548 no 2520 0.242288746788027 3788 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_942 3253-1115 227 µM -0.701156659941021 0.25152994892773 no 2521 0.241602626861411 3708 46497897
SGTC_2017 5132927 60.65 µM -0.702439368475564 0.251138169997301 no 2522 0.241202600531591 3676 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3042 9091578 49.47 µM -0.703137866568181 0.250924962857791 no 2523 0.240984917943452 3639 25236497
SGTC_3268 9137683 49.47 µM -0.70347172473986 0.250823090992712 no 2524 0.240880910869691 3689 1953228
SGTC_2836 9010338 19.48 µM -0.70367785948026 0.250760202971539 no 2525 0.240816705762652 3616 2994051
SGTC_1851 st056236 18.9 µM -0.704408941348583 0.250537230306255 no 2526 0.240589069651747 3689 5393171
SGTC_1382 3002-2117 298 µM -0.705662399481985 0.250155182687307 no 2527 0.240199054611594 3723 1497314
SGTC_1904 st060225 78 µM -0.70602216459659 0.250045585223954 no 2528 0.240087176928463 3659 66595
SGTC_1605 st000082 49.1 µM -0.706323596457977 0.249953777797357 no 2529 0.239993461260609 3698 1114022
SGTC_1226 3909-7979 35.4 µM -0.707495090737651 0.249597144453515 no 2530 0.239629431216431 3702 6615510
SGTC_493 zm226600 134 µM -0.707555486425891 0.249578765764292 no 2531 0.239610672037692 3701 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2809 7964133 12.99 µM -0.709104362292515 0.249107681365061 no 2532 0.239129858049886 3709 1253665
SGTC_2459 5811157 9.22 µM -0.71005978769876 0.248817328597199 no 2533 0.238833530692543 3663 2870684 YBR192W RIM2
SGTC_613 3914-0030 117 µM -0.71077998269217 0.248598581253802 no 2534 0.238610293410908 3471 1145395
SGTC_1950 st077106 7.18 µM -0.710848632583445 0.248577735331609 no 2535 0.238589020116015 3694 13831864
SGTC_2237 6667747 47.222 µM -0.711980907939581 0.248234047990973 no 2536 0.238238299328622 3644 729940 YDL015C TSC13
SGTC_2690 usnic acid 100 µM -0.712173897079646 0.248175493952718 no 2537 0.238178549383601 3733 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2555 cholic acid 100 µM -0.712628025447413 0.248037737805638 no 2538 0.23803798244534 3725 6708657 Influences liver metabolism.
SGTC_948 3448-0295 75.3 µM -0.712783144717358 0.247990692985816 no 2539 0.237989978598733 3710 678569
SGTC_2316 5844804 197.44 µM -0.713010538689347 0.247921737185563 no 2540 0.237919617918703 3754 776813
SGTC_2413 inermin 26.06 µM -0.713361608393453 0.247815297590911 no 2541 0.237811011656649 3758 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3213 9129884 49.47 µM -0.715096869283912 0.247289548413037 no 2542 0.237274594169007 3660 17190742
SGTC_2497 7-hydroxyflavone 100 µM -0.715283870402307 0.247232926447876 no 2543 0.237216826605619 3676 5281894
SGTC_2172 5754775 163.918 µM -0.715464011670206 0.247178388129381 no 2544 0.237161185463537 3659 2263357
SGTC_389 tpck 16.7 µM -0.716385912490819 0.246899380590716 no 2545 0.236876545577995 3701 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1958 st076513 41.9 µM -0.716698765663367 0.246804735847616 no 2546 0.236779993842273 3670 732122 YGL099W LSG1
SGTC_3314 9135860 59.4275 µM -0.717104409370073 0.246682048916649 no 2547 0.236654837621272 3681 25252478
SGTC_2934 9036370 36.88 µM -0.718264380925186 0.246331395851676 no 2548 0.236297144020408 3725 6462800
SGTC_1834 st055981 52.8 µM -0.719181219229751 0.246054429804854 no 2549 0.236014634756117 3744 471719 YDL150W RPC53
SGTC_2611 pyromycin 23.93 µM -0.719669978223516 0.245906849766536 no 2550 0.23586410746883 3700 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1944 st076371 56.9 µM -0.720649314151577 0.24561128377491 no 2551 0.235562652331423 3721 24208455
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.722939119009043 0.244920960300378 no 2552 0.234858644278827 3705 6708760
SGTC_2345 9052315 157.45 µM -0.722971987159972 0.244911058915776 no 2553 0.234848547330495 3730 6469265
SGTC_1404 3909-7820 48.3 µM -0.723035719439951 0.244891860463054 no 2554 0.234828969744012 3676 23741373
SGTC_2050 5263056 171 µM -0.723119939661325 0.244866491548549 no 2555 0.234803099957493 3731 763468 YGL055W OLE1
SGTC_3127 9126946 49.47 µM -0.723183590897032 0.244847319386636 no 2556 0.234783549357663 3691 27243249
SGTC_3208 9114115 49.47 µM -0.724151652707675 0.244555832546796 no 2557 0.234486318250744 3714 650895
SGTC_452 diindolylmethane 8 µM -0.725223192649733 0.244233406152142 no 2558 0.234157558381101 3675 3071 Inhibits expression of several cancer promoting factors.
SGTC_765 1319-0117 244 µM -0.725561321653737 0.244131710715337 no 2559 0.234053869800201 3687 3487746 YGL099W LSG1
SGTC_651 3253-0966 34.4 µM -0.726264987109576 0.243920150024653 no 2560 0.23383816958704 3746 781462
SGTC_1205 4161-2785 76 µM -0.726805499349129 0.243757709400886 no 2561 0.23367255687328 3762 3498106
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.726863536294952 0.243740270978363 no 2562 0.233654778245253 3756 6708784 An antioxidant flavonoid
SGTC_3256 9138902 49.47 µM -0.727134160068442 0.243658965259365 no 2563 0.233571887172506 3737 17228773
SGTC_1682 st012968 530 nM -0.727358848510151 0.243591471397053 no 2564 0.233503078315934 3722 24207270
SGTC_3254 9136651 49.47 µM -0.727464028770642 0.243559879908262 no 2565 0.233470871651188 3718 16454030
SGTC_1660 st012960 28.1 µM -0.72864586218371 0.243205061698267 no 2566 0.233109158430734 3704 24207266
SGTC_1297 1068-0111 14.1 µM -0.728961618451612 0.243110310491232 no 2567 0.233012570419059 3677 767057
SGTC_2458 5808907 16.39 µM -0.729254814027766 0.243022347106203 no 2568 0.232922903495906 3777 2731747
SGTC_2849 9019321 12.99 µM -0.731881703394998 0.242235006688773 no 2569 0.232120387315354 3710 16489627
SGTC_439 amiodarone 34.4 µM -0.732000393911296 0.242199465030488 no 2570 0.232084163672643 3648 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2597 laccaic acid a 100 µM -0.732700193446383 0.241989968818087 no 2571 0.231870652983728 3728 5491415 A textile dye.
SGTC_940 3232-1287 54.8 µM -0.732905526513682 0.241928517727189 no 2572 0.23180802608804 3676 1585493 YIL048W NEO1
SGTC_2411 st077133 39.94 µM -0.733793504780692 0.2416628653607 no 2573 0.231537299891798 3826 1403142 YNL221C POP1
SGTC_2790 5423970 71.43 µM -0.73527185411931 0.241220945901301 no 2574 0.231086973007384 3768 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_640 3381-0960 37.1 µM -0.735717551050118 0.241087800996138 no 2575 0.230951303148286 3766 1745025
SGTC_645 0845-0943 5.41 µM -0.735909133468955 0.241030581061757 no 2576 0.230892999251558 3737 1885106
SGTC_3191 9110352 49.47 µM -0.7368172702914 0.240759448271237 no 2577 0.23061673961898 3701 17122424
SGTC_1708 st033234 31.827 µM -0.738329715897884 0.240308262031417 no 2578 0.230157056527231 3826 674664
SGTC_505 gw-5074 63.9 µM -0.740582097703908 0.239637195957008 no 2579 0.229473432999738 3782 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2882 9058044 58.44 µM -0.740639417691994 0.239620131613841 no 2580 0.229456050590794 3695 18076804
SGTC_1057 3448-5381 134 µM -0.740683433525184 0.239607028410216 no 2581 0.229442703196157 3767 5497911
SGTC_820 1582-0060 59.9 µM -0.740981694915324 0.23951824839987 no 2582 0.229352269651194 3750 3848840
SGTC_2482 5981709 142.65 µM -0.74177407670991 0.239282476557868 no 2583 0.229112114732476 3743 877755
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.744010290295086 0.238617779401534 no 2584 0.228435124851403 3782 23665772 A membrane-active detergent.
SGTC_2971 9092186 9.93 µM -0.744427098935395 0.238493998088721 no 2585 0.22830906485555 3766 25236400
SGTC_2868 9035608 32.47 µM -0.744502698622711 0.238471550716926 no 2586 0.228286204604941 3726 6462614
SGTC_2506 ethyl hematommate 54.16 µM -0.745311288380091 0.23823153326659 no 2587 0.228041779258635 3820 3940691 An allergen.
SGTC_2284 7945075 39.21 µM -0.745330603197389 0.238225801578588 no 2588 0.2280359424607 3825 1245402
SGTC_1236 0330-0013 258 µM -0.747069636865019 0.237710051639823 no 2589 0.227510763555743 3755 4617066
SGTC_2436 5633522 8.09 µM -0.747442794618758 0.237599463106679 no 2590 0.227398160731131 3721 5724242
SGTC_2441 5730946 39.09 µM -0.748086794318641 0.237408674640355 no 2591 0.227203903420183 3800 1774275
SGTC_1336 1486-0901 104 µM -0.74944892667375 0.237005412650468 no 2592 0.226793335473323 3781 5006114
SGTC_3022 9087993 49.47 µM -0.750336232754037 0.236742926550223 no 2593 0.226526112876169 3779 17173644
SGTC_552 k242-0005 476 µM -0.751217807674548 0.236482294280347 no 2594 0.226260792416829 3791 4088318
SGTC_700 3453-2283 142 µM -0.751962113272415 0.236262367856743 no 2595 0.22603692154452 3808 565664
SGTC_1815 st051655 58.2 µM -0.752069018879001 0.236230788783947 no 2596 0.226004776958968 3707 5984156
SGTC_252 miconazole 1.30953 nM -0.752615074301083 0.236069524586134 no 2597 0.22584062826951 3715 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1423 4048-0112 5.59 µM -0.753041574059982 0.235943610447498 no 2598 0.225712465893533 3770 X1423
SGTC_1961 st076550 68.7 µM -0.755621682275352 0.235182683285966 no 2599 0.224938026142839 3751 1579337
SGTC_2585 alliin 100 µM -0.756206812295683 0.235010305078057 no 2600 0.224762604517206 3802 87310 A garlic compound which reacts with lipids.
SGTC_3136 9095672 49.47 µM -0.75638433403508 0.234958021310793 no 2601 0.224709398949546 3560 17217380
SGTC_752 1896-0090 130 µM -0.756697193694614 0.234865893416985 no 2602 0.224615648241319 3754 772567
SGTC_255 tunicamycin 200.472 nM -0.756998517024879 0.234777181507788 no 2603 0.224525375458889 3736 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3280 9140961 49.47 µM -0.758213799543976 0.234419581051047 no 2604 0.224161500696235 3796 4901226
SGTC_2992 9074591 71.4286 µM -0.759166159165101 0.234139557195929 no 2605 0.223876583406949 3746 17741321
SGTC_2064 5220758 200 µM -0.759630011927238 0.234003236916107 no 2606 0.223737887208886 3810 788518
SGTC_2591 skatole 100 µM -0.760493587856174 0.233749560365495 no 2607 0.223479800319403 3802 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1896 st058441 89 µM -0.760850252541949 0.233644834146167 no 2608 0.223373257531976 3798 688759
SGTC_2844 9010103 25.97 µM -0.760951362165299 0.233615150410201 no 2609 0.223343059349029 3794 2480525
SGTC_762 1165-0429 115 µM -0.761343013961694 0.233500189121119 no 2610 0.223226107522178 3728 5967793
SGTC_3324 9138759 60.749 µM -0.762621328268575 0.233125184808193 no 2611 0.22284463052052 3808 45595710
SGTC_1799 st045822 46.1415 µM -0.763530755798468 0.232858600235723 no 2612 0.222573463689805 3756 3674992
SGTC_2927 9011802 47.9 µM -0.764939236958751 0.232446060307145 no 2613 0.222153864024418 3783 43912568
SGTC_3282 9108498 15.4605 µM -0.765151225273374 0.23238400477454 no 2614 0.222090749841283 3783 16459645
SGTC_2951 9072950 58.06 µM -0.765502919260298 0.232281073401991 no 2615 0.221986064390936 3785 16488155
SGTC_1742 st038235 28.8875 µM -0.767357548688273 0.231738693052052 no 2616 0.221434480499755 3821 564103 YBR002C RER2
SGTC_1985 st071382 65.5 µM -0.768167841414169 0.231501947253234 no 2617 0.22119373815565 3806 6123237
SGTC_2729 fluphenazine 10.66 µM -0.76949506922774 0.231114458360394 no 2618 0.220799735271806 3710 3372 An atypical antipsychotic.
SGTC_1987 st072290 61.9 µM -0.7701291226556 0.230929472035684 no 2619 0.220611651144125 3804 54697379
SGTC_2930 9013230 14.89 µM -0.772351812373474 0.230281651246108 no 2620 0.219953042970718 3799 2995857
SGTC_3155 9099265 49.47 µM -0.772378055450679 0.230274008565777 no 2621 0.219945273594348 3776 25236499
SGTC_3143 9086658 49.47 µM -0.77286318220066 0.230132752336952 no 2622 0.219801678089981 3869 25236626
SGTC_2906 7926292 26.41 µM -0.773541236321111 0.229935401953979 no 2623 0.219601067084003 3758 2966319
SGTC_32 0928-0142 34.1 µM -0.774133720232437 0.229763034703805 no 2624 0.219425859238408 3751 2244242
SGTC_960 1222-0186 7.7 µM -0.7744393649806 0.229674143888083 no 2625 0.219335506157693 3829 3126296
SGTC_924 2046-0044 21.3 µM -0.775627518537557 0.229328775635458 no 2626 0.218984473671075 3783 3623589
SGTC_1994 st072947 40.9 µM -0.776195623003276 0.229163743987891 no 2627 0.21881674503719 3861 5286565 YDL195W SEC31
SGTC_824 1304-0008 100 µM -0.776605379617405 0.229044752995818 no 2628 0.218695813333473 3814 768245
SGTC_1199 1638-0010 4.46 µM -0.776975249526937 0.228937374647258 no 2629 0.218586686456297 3778 3111136
SGTC_2517 totarol 10 µM -0.777754459304021 0.228711251744527 no 2630 0.218356890056598 3792 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_726 3448-4391 34.2 µM -0.778847703531198 0.228394209064072 no 2631 0.21803471660491 3852 1356692
SGTC_1359 1582-0056 520 nM -0.779766260929887 0.22812801689089 no 2632 0.217764234440309 3884 3661189
SGTC_1502 4534-4282 27.7 µM -0.781040620708316 0.227759004486712 no 2633 0.21738930199195 3776 3278949
SGTC_2052 5265182 7.135 µM -0.782411299951596 0.227362476426613 no 2634 0.21698644751724 3810 1239884
SGTC_889 0919-1524 82.7 µM -0.782666801591029 0.227288604593755 no 2635 0.216911401115737 3851 3905452
SGTC_3010 9080089 71.4286 µM -0.783249902816797 0.227120066295219 no 2636 0.216740187777479 3805 17027233
SGTC_1804 st050076 49.1 µM -0.787231663450427 0.225971071861389 no 2637 0.215573132450788 3842 3895976
SGTC_1656 st012921 11 µM -0.789337769956264 0.225364655760963 no 2638 0.214957308416862 3747 6732821
SGTC_2694 st077685 81.9 µM -0.790214642371155 0.225112447805014 no 2639 0.214701213094131 3808 2838096
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.790265861760682 0.225097720917352 no 2640 0.214686259677652 3790 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3016 9080866 49.47 µM -0.790390973258839 0.225061750449276 no 2641 0.214649736126565 3813 17066299
SGTC_2628 lathosterol 100 µM -0.796154672496075 0.223408180011924 no 2642 0.212971069900317 3880 6710616
SGTC_2280 7785178 200 µM -0.798403142547496 0.222764986638723 no 2643 0.212318290107449 3849 2954328
SGTC_449 xestospongin c 11.1929 µM -0.798677572848858 0.222686555914407 no 2644 0.212238697164565 3844 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2006 4011487 200 µM -0.799062843683947 0.222576474116729 no 2645 0.212126986607479 3888 45595294
SGTC_1928 4'-methoxychalcone 40.3 µM -0.799619516132466 0.222417473277772 no 2646 0.211965638320049 3889 641818
SGTC_1901 st060216 58.6 µM -0.799892772992216 0.222339447375103 no 2647 0.211886462674065 3829 688792
SGTC_1769 st044406 64.4 µM -0.80071967196873 0.222103429365216 no 2648 0.211646975715486 3827 670903
SGTC_473 2-arachidonoylglycerol 10 µM -0.801808805033042 0.221792781409252 no 2649 0.211331782269659 3714 5282280 An endocannabinoid.
SGTC_3008 9078912 71.4286 µM -0.805042345851307 0.220871958511514 no 2650 0.210397621990057 3822 16648731
SGTC_972 1319-0219 195 µM -0.806304720972823 0.220513063932541 no 2651 0.210033584533532 3826 23903702
SGTC_2046 4110841 106 µM -0.806734732692874 0.220390887492272 no 2652 0.209909664447116 3870 44119630 YMR134W ERG29
SGTC_2522 biochanin a 4.94 µM -0.807774468736424 0.220095634422523 no 2653 0.209610212604639 3821 5280373 A possible chelator.
SGTC_709 3807-1509 243 µM -0.808521258032056 0.219883709301111 no 2654 0.209395286761692 3904 1886677 YPL242C IQG1
SGTC_1612 st002233 45.4 µM -0.808861151787062 0.219787292474094 no 2655 0.209297508349721 3848 1035021
SGTC_1155 4088-0394 48.2 µM -0.80891878338801 0.219770946666072 no 2656 0.209280931932735 3826 2326248
SGTC_3212 9128307 49.47 µM -0.809149955484707 0.219705387313139 no 2657 0.209214448312767 3810 27243542
SGTC_2598 perillyl alcohol 100 µM -0.8095550001429 0.219590545571569 no 2658 0.209097990035253 3877 10819 An apoptosis inducer.
SGTC_2606 farnesol 9.78 µM -0.809935126666412 0.219482800199909 no 2659 0.208988730939724 3862 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1229 0139-0193 12.2 µM -0.812267131041632 0.218822467728578 no 2660 0.208319183318394 3872 3090752
SGTC_3168 9103419 49.47 µM -0.812500197626613 0.218756535273618 no 2661 0.208252336611436 3783 16649256
SGTC_2781 5567276 71.43 µM -0.812938615970294 0.218632541624914 no 2662 0.208126626491112 3904 2853274
SGTC_2841 9004761 38.96 µM -0.812942361998713 0.21863148234603 no 2663 0.208125552564633 3856 2991039
SGTC_121 0557-0495 61.343 µM -0.813063470071311 0.218597237741675 no 2664 0.208090834577815 3994 3104427
SGTC_1308 1187-1617 41.4 µM -0.814333918433941 0.218238191013057 no 2665 0.207726841875028 3844 2882570
SGTC_3229 9132204 49.47 µM -0.815810303519462 0.217821370852953 no 2666 0.207304319657007 3869 17682924
SGTC_414 piperonyl butoxide 100 µM -0.817195551137757 0.217430698929056 no 2667 0.206908342267116 3845 5794 A potent inhibitor of cytochrome P450.
SGTC_1684 st024538 14.6195 µM -0.820636771459084 0.216461947639075 no 2668 0.205926597958077 3848 6732859
SGTC_290 2043-6722 48.1 µM -0.820643005741703 0.216460194871588 no 2669 0.205924821893386 3879 773758 YLR208W SEC13
SGTC_2124 5246320 200 µM -0.8219587972882 0.216090444135688 no 2670 0.20555017365382 3880 579342
SGTC_2864 9034755 47.6 µM -0.822545114413086 0.215925800985436 no 2671 0.205383360702177 3829 4930451
SGTC_2858 9025781 8.96 µM -0.823136535431039 0.215759798276522 no 2672 0.20521517712626 3822 4894980 YPL153C RAD53
SGTC_3025 9087895 49.47 µM -0.823274732027483 0.215721019300096 no 2673 0.205175889681656 3888 17173641
SGTC_1714 st033236 13.627 µM -0.825106434554079 0.215207411976937 no 2674 0.204655583463717 3872 2916566
SGTC_1217 1183-1422 255 µM -0.825172597974972 0.215188873119711 no 2675 0.204636804043295 3892 2849664
SGTC_419 nsc-638432 893 µM -0.827632573368391 0.214500251181255 no 2676 0.203939307612705 3841 368090
SGTC_2431 5490079 200 µM -0.828392409014718 0.214287809336678 no 2677 0.203724152059133 3934 5722345
SGTC_3158 9100007 49.47 µM -0.828618577624775 0.214224598679285 no 2678 0.203660136153807 3892 19297233
SGTC_1927 st060202 13.8 µM -0.829127253679851 0.214082471166237 no 2679 0.203516201746905 3785 688887
SGTC_1036 k216-0215 33.5 µM -0.831546338810373 0.213407313968503 no 2680 0.202832530960105 3873 622330
SGTC_3057 9095946 49.47 µM -0.831893459676557 0.213310535822219 no 2681 0.202734541932745 3889 24540043
SGTC_133 0724-0033 378.92 µM -0.832563279950449 0.213123860637414 no 2682 0.202545537804051 3734 280309
SGTC_2902 5787006 60.46 µM -0.834525370267835 0.212577585682492 no 2683 0.201992498529842 3838 591003
SGTC_511 blebbistatin 171 µM -0.83714858276446 0.21184852357369 no 2684 0.20125452744446 3957 3476986 A myosin inhibitor.
SGTC_2751 anetholtrithion 17.25 µM -0.837360373084428 0.211789725174212 no 2685 0.201195016474519 3896 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_719 2810-4230 27.3 µM -0.839612251654986 0.211165136979861 no 2686 0.200562913811062 3874 721079
SGTC_3038 9091290 49.47 µM -0.840116109491355 0.21102553329092 no 2687 0.200421644270551 3870 25236843
SGTC_3273 9137859 49.47 µM -0.841412387243688 0.210666622868694 no 2688 0.200058474157811 3955 2377234
SGTC_76 0433-0009 400.328 µM -0.841813411419548 0.210555660788148 no 2689 0.199946201872125 3996 2841569
SGTC_2656 pseudo-anisatin 100 µM -0.841875838627807 0.210538390469088 no 2690 0.199928727917057 3926 6708809 A neurotoxin.
SGTC_3065 9113888 49.47 µM -0.843929840699678 0.209970620130418 no 2691 0.199354305975247 3957 16648368
SGTC_1812 st052057 4.327 µM -0.844066296052647 0.209932932836761 no 2692 0.199316180123579 3907 3645418
SGTC_2120 5538279 151.968 µM -0.845274531763613 0.209599406441055 no 2693 0.198978788656445 3876 2058197
SGTC_97 0535-0701 19.132 µM -0.845448595573843 0.209551382841475 no 2694 0.198930210919558 3819 2832013 YGL099W LSG1
SGTC_2896 9052656 71.43 µM -0.845715972218573 0.209477627163802 no 2695 0.198855605355824 3820 6469436
SGTC_1080 nisoldipine 24.4 µM -0.847681613164118 0.208935875385297 no 2696 0.198307654474394 3880 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2213 7173844 200 µM -0.847730028546575 0.208922542008345 no 2697 0.198294169494441 3872 892728
SGTC_3121 9125696 49.47 µM -0.848530316933626 0.208702218841132 no 2698 0.198071347948011 3968 1235365
SGTC_1184 1269-1718 139 µM -0.848617324354641 0.208678273544048 no 2699 0.198047131886394 3975 5403821
SGTC_2226 7298446 200 µM -0.849702764723689 0.208379685826546 no 2700 0.197745180474638 3878 3283010
SGTC_3333 9141820 12.094 µM -0.850880376684193 0.208056028314327 no 2701 0.197417903287871 3896 1939433
SGTC_1266 0828-0227 32.9 µM -0.852225686914159 0.207686643601499 no 2702 0.197044421186234 3928 3913820
SGTC_643 k048-0106 28.4 µM -0.852337575196126 0.207655939657399 no 2703 0.197013378278486 3931 6763920
SGTC_751 0833-0568 350 µM -0.855160511489346 0.206882168305999 no 2704 0.196231146942223 3977 6954252
SGTC_257 daunorubicin 18.5 µM -0.855191403071467 0.206873710324421 no 2705 0.196222597361604 3947 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_639 0833-0042 114 µM -0.855731990995151 0.206725732820731 no 2706 0.196073020348076 3895 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_187 1488-2104 32.728 µM -0.857247691515808 0.206311167811389 no 2707 0.195654005222645 3914 2852859
SGTC_1055 3448-0672 86 µM -0.85774284954166 0.206175842105157 no 2708 0.195517236772585 3948 748378
SGTC_2057 5236571 38.335 µM -0.859236896662427 0.205767841053556 no 2709 0.195104915465726 3902 54684039 YBR257W POP4
SGTC_410 α-linolenic acid 100 µM -0.860187442805185 0.205508511232906 no 2710 0.194842862758512 3989 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1616 st002734 56.1 µM -0.861327841968953 0.205197641554171 no 2711 0.194528752766673 3867 4026101
SGTC_2376 9072922 81.32 µM -0.863051456958456 0.204728319501613 no 2712 0.194054587918809 3968 17087968
SGTC_2516 gossypol 71.55 µM -0.863589274430561 0.204582008315108 no 2713 0.19390677910084 3956 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_160 3453-0671 289.699 µM -0.866058950666268 0.203910941588097 no 2714 0.193228917341563 3977 5322268
SGTC_1626 st003712 1.76 µM -0.868675598299797 0.203201372543641 no 2715 0.192512295954234 3937 24207035
SGTC_1704 st028805 70.8 µM -0.868731566995999 0.203186211357629 no 2716 0.192496985573961 3964 2876101
SGTC_1104 tacrolimus 29.8 µM -0.87013542122431 0.202806146574955 no 2717 0.192113201188146 3949 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2508 celastrol 40.54 µM -0.870162347854216 0.202798860895176 no 2718 0.192105844589522 3869 122724 Celastrol is a natural product and antioxidant.
SGTC_2943 9068529 45.32 µM -0.870199824159201 0.202788720994636 no 2719 0.192095606011226 3926 3270634
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.871769718852924 0.202364229409025 no 2720 0.191667008606433 3920 66535 A nucleotide analog.
SGTC_2863 9028737 58.44 µM -0.87361434490001 0.201866131477597 no 2721 0.191164155751103 3917 6460917
SGTC_2201 6605497 169.863 µM -0.875132875299704 0.201456639394165 no 2722 0.190750805564561 3871 670741
SGTC_1516 st013856 110 µM -0.875754417965858 0.20128917575457 no 2723 0.190581777420713 3999 5281404 A mutagen and neurotoxin.
SGTC_2386 9075165 157.42 µM -0.876465781379759 0.201097613958852 no 2724 0.190388435459971 3899 16452277
SGTC_2731 amoxapine 43.43 µM -0.879434733434198 0.200299291306218 no 2725 0.189582803203199 4017 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1699 st031318 29.054 µM -0.879439670000524 0.200297965498695 no 2726 0.18958146540305 3991 5340658
SGTC_1244 0416-0015 52.5 µM -0.881585471757556 0.199722169559882 no 2727 0.18900050722534 3928 96201
SGTC_1862 st057513 3.81 µM -0.883572050502258 0.199189987617071 no 2728 0.188463636135226 3917 5393163
SGTC_2270 7924575 90.91 µM -0.884797124485157 0.198862230366927 no 2729 0.188133030319676 3962 1262135
SGTC_2963 9082507 9 µM -0.885737509749607 0.198610859640545 no 2730 0.187879495290778 4007 16459611
SGTC_1628 st004252 77.7 µM -0.886700277622386 0.198353704539287 no 2731 0.187620144426942 3988 692968
SGTC_3110 9122132 49.47 µM -0.88885931752475 0.197777756413086 no 2732 0.187039345942907 4061 918317
SGTC_1087 pterostilbene 9.05 µM -0.888934687236863 0.197757668966943 no 2733 0.187019091016881 4012 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1518 st038567 90.8 µM -0.889026472006735 0.197733208263992 no 2734 0.186994426525593 3922 77966
SGTC_1864 st057645 30.4 µM -0.889498411789116 0.197607464866472 no 2735 0.186867638193787 3989 688666
SGTC_812 4251-0442 148 µM -0.892911541641557 0.196699511918156 no 2736 0.185952272906883 3955 5723007
SGTC_2978 9011784 42.97 µM -0.893471809087614 0.196550712663963 no 2737 0.185802281196021 3965 2994934
SGTC_909 3448-9333 149 µM -0.895757605470858 0.195944343952469 no 2738 0.185191118345201 3885 3344074
SGTC_827 3253-0474 693 µM -0.895762090919576 0.195943155183923 no 2739 0.185189920280923 3982 5402065
SGTC_466 geldanamycin 89.2 µM -0.898296332183084 0.195272210634781 no 2740 0.184513793720403 3876 5288382 HSP90 inhibitor.
SGTC_192 3455-0609 60.9 µM -0.900804074999728 0.194609657573943 no 2741 0.183846250269125 4037 3769639
SGTC_2612 dictamnine 15.46 µM -0.901408847088096 0.194450079961681 no 2742 0.183685489603433 3950 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3173 9105693 49.47 µM -0.902828639972173 0.194075760782589 no 2743 0.18330842421327 3982 17096658
SGTC_418 lividomycin a 100 µM -0.90311374469544 0.194000647733337 no 2744 0.183232764975714 3947 72394 An antibiotic.
SGTC_2481 5478948 45.16 µM -0.904499209672364 0.193635888499727 no 2745 0.182865376625432 4035 77792
SGTC_112 phenothiazine 287.218 µM -0.907445894215944 0.192861490002332 no 2746 0.182085524590182 3896 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2353 9059630 146.67 µM -0.908807264886373 0.192504357071549 no 2747 0.18172593554864 4033 4779114
SGTC_1384 3089-0840 101 µM -0.912302648614982 0.191589254620984 no 2748 0.180804710225005 3968 1069836
SGTC_298 1391-0729 10 µM -0.912568185541699 0.191519845291612 no 2749 0.180734846526068 3938 3237558
SGTC_497 capsazepine 133 µM -0.912710167767182 0.191482738541348 no 2750 0.180697497448646 3956 2733484 A calcium channel blocker.
SGTC_1203 3992-3522 103 µM -0.913586594096564 0.191253783927955 no 2751 0.180467056618199 4125 5322312
SGTC_2440 5628896 157.78 µM -0.91738313818729 0.190263927110298 no 2752 0.179470952706052 3988 5522048
SGTC_2247 cerulenin 830 nM -0.920356468584263 0.189490905132634 no 2753 0.178693254529522 4033 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_156 3474-0145 5.642 µM -0.922512097977706 0.188931683617908 no 2754 0.178130761416671 3839 2265471
SGTC_2709 st078560 56 µM -0.92386059322301 0.18858236942818 no 2755 0.177779451229302 3976 17250903
SGTC_3255 9139072 49.47 µM -0.924477923614477 0.188422589131551 no 2756 0.17761877016769 4004 17646060
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.924944392811548 0.188301910824792 no 2757 0.177497416629255 4067 6710655
SGTC_1361 1608-0041 5.61 µM -0.927343358918958 0.187682037760777 no 2758 0.176874144437534 3970 X1361
SGTC_1436 4092-1007 8.32 µM -0.927934570487947 0.187529467393632 no 2759 0.176720755253462 3980 2881121
SGTC_3192 9110362 49.47 µM -0.929178766806227 0.187208635692154 no 2760 0.176398224727005 4027 16649480
SGTC_1089 terbinafine 2.25 µM -0.93018997110833 0.18694813411173 no 2761 0.176136366765287 4008 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_366 0181-0206 4.31 µM -0.930550629694877 0.186855277272549 no 2762 0.176043031427988 4005 274874
SGTC_2911 7942208 15.64 µM -0.931454738716724 0.186622626642338 no 2763 0.175809193463565 4052 1243384
SGTC_1860 st056228 74.6 µM -0.931905196136222 0.186506779270552 no 2764 0.175692761017922 3998 688679
SGTC_2733 amorolfine 100 µM -0.932112647136549 0.18645344258762 no 2765 0.175639156340997 4087 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2222 6885208 172.143 µM -0.932809177242121 0.186274430359574 no 2766 0.17545925100451 3942 609514
SGTC_228 caffeine 993.056 µM -0.933157366921619 0.186184983554195 no 2767 0.175369361610378 4009 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3079 9117512 49.47 µM -0.933279150907584 0.186153704625007 no 2768 0.175337928488437 4046 7185044
SGTC_1902 st060212 70.5 µM -0.936532672397457 0.185319278131575 no 2769 0.174499499320058 4012 688944
SGTC_681 1642-0006 26.6 µM -0.936604454555147 0.185300894475868 no 2770 0.174481029887437 4035 4446530
SGTC_2291 7917025 104.35 µM -0.937624595218866 0.185039755376743 no 2771 0.174218683571493 3950 2964612
SGTC_1367 1812-0510 76.9 µM -0.942625876978221 0.183762820883577 no 2772 0.172936149521508 4055 1142582 YDR527W RBA50
SGTC_1696 st025591 34.7925 µM -0.942761320936969 0.183728315655718 no 2773 0.172901500003261 4033 2787147
SGTC_2462 5162487 171.77 µM -0.946904146901356 0.18267485440977 no 2774 0.171843812316679 3914 2259986
SGTC_2511 berberine 10.47 µM -0.94742094014134 0.182543706391387 no 2775 0.17171216244706 4003 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1832 st054113 55 µM -0.948701821608428 0.18221890721772 no 2776 0.171386143651436 4040 1251267
SGTC_1614 st002383 48.6 µM -0.94902431495963 0.182137188005058 no 2777 0.17130412280623 4031 1947235
SGTC_538 2922-0838 53.3 µM -0.949200273547818 0.182092610088887 no 2778 0.171259381235381 3988 777039
SGTC_2514 salinomycin 42.74 µM -0.949511626495384 0.182013747643239 no 2779 0.17118023080255 4098 23682228 A polyether potassium ionophore.
SGTC_1771 st048882 4.1505 µM -0.949558603141818 0.182001850804356 no 2780 0.171168290689292 4055 4580403
SGTC_764 1951-2361 146 µM -0.949961946911525 0.181899723977873 no 2781 0.171065794214982 4008 5438930
SGTC_3044 9093193 49.47 µM -0.952931597918428 0.181148910740845 no 2782 0.170312364549159 4069 25236277
SGTC_3092 9117248 49.47 µM -0.954187255480945 0.180832029165627 no 2783 0.169994432289783 4116 17141857
SGTC_599 1935-0052 86.5 µM -0.954455740003962 0.180764318708181 no 2784 0.169926501460169 4034 9557311
SGTC_3288 9119690 36.221 µM -0.95483638029621 0.180668350369792 no 2785 0.16983022327815 4034 17595618 YKL019W RAM2
SGTC_226 1,3-diallylurea 8.28947 mM -0.955316340139351 0.180547386793289 no 2786 0.169708873333105 4004 74537 YKL182W FAS1
SGTC_1042 0350-0096 82 µM -0.956161700885587 0.180334455320582 no 2787 0.169495273060905 4026 3122515
SGTC_3263 9137018 49.47 µM -0.956507949265651 0.180247286962606 no 2788 0.169407835084886 4033 43844957
SGTC_1091 telmisartan 47.6 µM -0.959380306036149 0.17952518832279 no 2789 0.168683596330842 4091 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_813 k007-0158 173 µM -0.960250263633479 0.179306843816841 no 2790 0.168464637605002 4029 6523916
SGTC_2979 9012552 45.46 µM -0.963863687826321 0.178401724374988 no 2791 0.167557135627095 4074 17100905
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.96519727327782 0.178068405699886 no 2792 0.167223006221495 4059 6728940
SGTC_1717 st033143 58.0435 µM -0.966102078489508 0.177842480816454 no 2793 0.166996552296844 4115 674616
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.966169865491788 0.177825562058147 no 2794 0.166979594587171 4096 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_603 3794-0023 45.9 µM -0.966454217938986 0.177754602430403 no 2795 0.166908472604717 4087 3802260
SGTC_2227 7312221 64.1025 µM -0.966589393426885 0.177720875902514 no 2796 0.166874669484547 4112 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_823 0417-1665 178 µM -0.966605809050436 0.177716780449781 no 2797 0.166870564756291 4032 3429856
SGTC_3013 9080133 71.4286 µM -0.96862245652712 0.1772141100698 no 2798 0.166366797359303 4144 17050193
SGTC_365 0121-0052 13.6 µM -0.968769676846874 0.177177449075924 no 2799 0.166330059578673 4096 3101739
SGTC_356 1634-0012 32.5 µM -0.968929221132609 0.177137724561249 no 2800 0.166290252355741 4064 735457
SGTC_1160 4092-0570 10.5 µM -0.969566692635425 0.176979058352775 no 2801 0.166131260935602 4044 4994975
SGTC_773 4358-1457 44.6 µM -0.971786268288375 0.176427308520799 no 2802 0.165578444308844 4021 1186886
SGTC_1863 st057641 20.1 µM -0.973501420925594 0.176001696079418 no 2803 0.165152077174474 4068 3921635
SGTC_1290 0986-0249 10.2 µM -0.973572566256158 0.175984055530987 no 2804 0.165134406631364 3937 53329
SGTC_1180 1193-0155 285 µM -0.974340638241953 0.175793682683724 no 2805 0.164943716608211 4140 2921347
SGTC_1153 4055-0057 267 µM -0.975218308563283 0.175576304766568 no 2806 0.164725991131258 4105 882706
SGTC_2652 actinonin 100 µM -0.975713910054182 0.175453631433621 no 2807 0.164603128543384 4053 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1806 st050005 60.3 µM -0.97679284218036 0.175186757626438 no 2808 0.164335860197023 4100 5194765
SGTC_1870 st057514 26.5 µM -0.977149341967954 0.175098634039496 no 2809 0.164247611506872 4051 5393161
SGTC_2136 5328288 199.296 µM -0.977728961992158 0.174955417145648 no 2810 0.164104196786356 4065 262395
SGTC_3142 9086498 49.47 µM -0.978102540201217 0.174863150023584 no 2811 0.164011805817322 3986 25236367
SGTC_3033 9090887 49.47 µM -0.978919275966546 0.174661538511989 no 2812 0.163809933523455 4099 19325384
SGTC_513 4245-1575 41.7 µM -0.979169785027775 0.174599729850193 no 2813 0.163748047617527 3966 719745
SGTC_383 2324-0395 7.37 µM -0.979500298842257 0.174518202690427 no 2814 0.163666420513699 4062 3146421
SGTC_2467 5474540 200 µM -0.980248987147738 0.174333614723505 no 2815 0.163481614434046 4021 5413519
SGTC_1891 st059073 26.2 µM -0.98029194027655 0.174323028458496 no 2816 0.163471016004126 4145 688754
SGTC_528 3492-0019 172 µM -0.980606663867946 0.174245473872615 no 2817 0.163393373437512 4065 2869262
SGTC_2492 derrusnin 100 µM -0.98171919973588 0.173971497153896 no 2818 0.163119101970931 4032 1715307 Part of coumarin class of compounds.
SGTC_2409 alverine citrate 63.97 µM -0.983599903804146 0.173508972083592 no 2819 0.162656136231473 4232 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2339 9000433 200 µM -0.985374663558987 0.173073220505337 no 2820 0.162220035086532 4092 2988954
SGTC_622 1348-1566 26.3 µM -0.98560329776611 0.173017135346112 no 2821 0.16216390956834 4100 7340407
SGTC_1362 1611-0397 101 µM -0.986184408738624 0.172874637924669 no 2822 0.162021314366079 4041 27816
SGTC_1328 1441-0025 69.2 µM -0.987511731464862 0.172549438409558 no 2823 0.161695917321347 4049 4562601
SGTC_2975 9084847 53.72 µM -0.987951423101931 0.172441798225546 no 2824 0.161588219614856 4137 27211724
SGTC_1604 st002052 72.4 µM -0.988238260547583 0.172371601112213 no 2825 0.161517987096913 4144 6254834 YHR062C RPP1
SGTC_805 3852-0218 479 µM -0.990633081043854 0.171786233413602 no 2826 0.160932389097626 4026 6615355
SGTC_573 3702-0553 84.7 µM -0.991332607077976 0.171615487632272 no 2827 0.160761598030563 4023 1222756
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.991832109651504 0.171493631518774 no 2828 0.160639715656796 4170 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_391 gliotoxin 8.33 µM -0.995809625386845 0.170525270907728 no 2829 0.159671326317326 4181 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_128 0906-2981 13.371 µM -0.9967491356128 0.170297051187973 no 2830 0.159443146528025 4065 6740226
SGTC_3290 9121031 71.43 µM -0.997199797532038 0.170187648793827 no 2831 0.15933376961261 4100 17014854
SGTC_629 3448-6466 76.7 µM -0.998196438770183 0.169945864777059 no 2832 0.159092056493929 4096 573744
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.999063636495794 0.169735662863361 no 2833 0.158881932564104 4169 5282309
SGTC_696 1560-0013 611 µM -1.00004526451141 0.16949792523867 no 2834 0.158644301492719 4155 1650269
SGTC_638 3970-0837 4.09 µM -1.00071975645927 0.16933469590563 no 2835 0.158481156615914 4059 4118451 YLR208W SEC13
SGTC_1376 2910-0861 41.3 µM -1.00315081961708 0.16874720792894 no 2836 0.157894048925953 4036 1112859
SGTC_1369 1866-0067 208 µM -1.00669157945757 0.167893898007179 no 2837 0.157041504951631 4117 3531355
SGTC_1435 4092-0789 56.7 µM -1.00986760704315 0.16713085470101 no 2838 0.156279362019809 4089 2248285
SGTC_3093 9117344 49.47 µM -1.01009321140589 0.167076738245287 no 2839 0.156225317177713 4131 24824913
SGTC_1867 st057372 64 µM -1.0109408967048 0.166873502199935 no 2840 0.156022359278132 4059 688837
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.01441801769429 0.166041517610491 no 2841 0.155191665219458 4078 688803
SGTC_1523 st012844 44.7 µM -1.01468582626763 0.165977549341555 no 2842 0.155127806309851 4209 4274103
SGTC_2799 7812892 81.82 µM -1.01621632378364 0.165612283108754 no 2843 0.154763192345369 4144 20205235
SGTC_1287 0971-0001 34.6 µM -1.0166383045041 0.165511665317627 no 2844 0.154662762557873 4095 4665869
SGTC_647 0140-0236 81 µM -1.01748368855705 0.165310209508009 no 2845 0.15446169399532 4118 990837
SGTC_2658 polymyxin b sulfate 77.05 µM -1.01799134232642 0.165189311421989 no 2846 0.154341035246818 4134 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.01862551284232 0.165038363707458 no 2847 0.154190393676083 4064 6708514
SGTC_1972 st070201 17.4 µM -1.02097739250149 0.164479340230648 no 2848 0.153632574910386 4110 2829099
SGTC_755 1995-0008 37.3 µM -1.02135041262169 0.164390789152022 no 2849 0.153544224930699 4071 689533
SGTC_1774 st048371 48.465 µM -1.02263344413246 0.164086446895809 no 2850 0.153240595298492 4099 4242727
SGTC_952 1185-0122 232 µM -1.02456671285467 0.163628555456442 no 2851 0.152783838809676 4050 678600
SGTC_1843 st055809 45.5 µM -1.02509840289792 0.163502771160406 no 2852 0.15265837952568 4180 16413835
SGTC_680 0417-1641 114 µM -1.02581430211742 0.163333506898726 no 2853 0.152489561645024 4092 2835990
SGTC_2025 5147754 141 µM -1.02637993594502 0.163199851299626 no 2854 0.152356265842226 4094 315777 YLR208W SEC13
SGTC_1794 st048918 76.9 µM -1.0275811109534 0.162916257232217 no 2855 0.152073456631667 4043 672303
SGTC_222 nsc-310342 10.666 µM -1.0308316898675 0.162150412433547 no 2856 0.151309877339766 4125 432556
SGTC_1333 1482-0047 286 µM -1.03275274038103 0.161698911884263 no 2857 0.150859812641214 4141 3811116
SGTC_1195 1502-0147 41.1 µM -1.03283172590392 0.161680365633403 no 2858 0.150841326965445 4092 817940
SGTC_2106 5357045 167.29 µM -1.03450819925431 0.161287047171174 no 2859 0.150449322845873 4143 668842
SGTC_1910 st062352 60.4 µM -1.03566727473867 0.161015480973397 no 2860 0.150178697296373 4039 2245730
SGTC_1683 st010134 710 nM -1.0358187968214 0.160980002095926 no 2861 0.15014334331463 4111 3818134
SGTC_2736 butenafine 14.65 µM -1.03688167967102 0.160731271647057 no 2862 0.149895501492899 4068 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2342 7990637 118.86 µM -1.03747167999738 0.160593311140578 no 2863 0.149758043711532 4186 2033102 YER133W GLC7
SGTC_2792 7535235 81.82 µM -1.03797182238271 0.160476422819765 no 2864 0.149641586831071 4141 1281891
SGTC_135 0933-0004 26.348 µM -1.03951780683246 0.160115462204264 no 2865 0.149281990445809 4108 21230617 YGL099W LSG1
SGTC_2232 chlorophetanol 41.5365 µM -1.04304216203052 0.159294572215735 no 2866 0.148464383035093 4203 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2334 9017922 200 µM -1.04554508739451 0.158713269454904 no 2867 0.147885556768129 4198 3163164
SGTC_3020 9089140 49.47 µM -1.04673012505595 0.158438530960793 no 2868 0.147612032770255 4174 17217859
SGTC_2715 st079500 56.4 µM -1.05054283218244 0.157556712731599 no 2869 0.146734304513916 4108 28246688
SGTC_1335 1486-0900 202 µM -1.05197185472414 0.157227035134584 no 2870 0.146406231421291 4137 X1335
SGTC_515 4092-1064 102 µM -1.05382117018883 0.156801069119765 no 2871 0.145982399578317 4188 717353
SGTC_2294 7971431 200 µM -1.05519273059791 0.156485638775886 no 2872 0.145668594075327 4142 5741572
SGTC_1935 st074532 41.6 µM -1.05775616232367 0.155897223809517 no 2873 0.145083311638781 4144 2829742
SGTC_3101 9120531 49.47 µM -1.05859613797099 0.15570473189523 no 2874 0.144891873257498 4183 24824904
SGTC_1633 st005664 67.9 µM -1.05887457760596 0.155640958247476 no 2875 0.144828451785854 4141 2063822
SGTC_3190 9110366 49.47 µM -1.06809578159965 0.153538672434713 no 2876 0.142738654264939 4169 17123768
SGTC_18 0111-0177 500 nM -1.06832155212211 0.153487437357539 no 2877 0.142687744961523 4228 721752
SGTC_884 0851-0618 334 µM -1.06846571175445 0.153454728515404 no 2878 0.142655244631819 4175 9642473
SGTC_649 1123-0311 367 µM -1.06877001934208 0.153385698349406 no 2879 0.142586655891405 4056 693629 YIL048W NEO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.06942317525854 0.153237603714117 no 2880 0.142439514558619 4164 5024745
SGTC_1164 k060-0068 93.7 µM -1.07098811658142 0.152883159143854 no 2881 0.142087386459182 4156 5963676
SGTC_465 cgp-37157 41 µM -1.07158196849844 0.152748799640315 no 2882 0.141953917940073 4110 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_300 r073-0011 5.04 µM -1.07378036867378 0.152252091518054 no 2883 0.141460565289348 4150 2735780
SGTC_706 4262-0057 46.9 µM -1.07583720870444 0.151788339633661 no 2884 0.141000034070677 4167 883298
SGTC_3214 9129694 49.47 µM -1.07770477957222 0.151368075799442 no 2885 0.140582762412861 4219 17158655
SGTC_1015 4130-4525 82 µM -1.07960770122377 0.150940653574626 no 2886 0.140158455287865 4176 1363237
SGTC_834 0312-0008 75.7 µM -1.07963128486325 0.150935361411143 no 2887 0.140153202150083 4162 6385573 YIL048W NEO1
SGTC_1283 0922-0125 16.4 µM -1.08273420643675 0.150240143499687 no 2888 0.139463208179306 4171 3360884
SGTC_233 rapamycin 362 pM -1.08289787909361 0.150203531552368 no 2889 0.139426876698176 4158 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.08579254910823 0.149557005240085 no 2890 0.138785391791616 4149 16623 A steroid.
SGTC_2268 7933382 153.85 µM -1.08613517970731 0.14948060159088 no 2891 0.138709595027158 4208 935025 YOR257W CDC31
SGTC_254 nsc-64875 3.808 µM -1.08698845202063 0.1492904425134 no 2892 0.1385209566336 4184 56993
SGTC_890 0929-0006 47.2 µM -1.08886479072741 0.148872852615181 no 2893 0.138106757446005 4151 1378169
SGTC_2089 5281248 129.67 µM -1.08970473490678 0.148686171387221 no 2894 0.137921614860344 4158 2737878
SGTC_779 1360-0071 233 µM -1.09015346403688 0.14858650355296 no 2895 0.137822774287238 4242 7566
SGTC_15 0266-0086 27.098 µM -1.09047088873861 0.148516026903513 no 2896 0.137752885042087 4238 1712902 YIL048W NEO1
SGTC_1784 st039334 36.3 µM -1.09076349102393 0.148451081286686 no 2897 0.137688482517179 4244 3496984
SGTC_2326 6164455 177.58 µM -1.09228597661618 0.148113458949859 no 2898 0.137353711121029 4147 2888790
SGTC_1344 1488-0097 29.1 µM -1.09311818203352 0.147929128665271 no 2899 0.137170956961067 4222 747966
SGTC_1189 1431-2119 7.28 µM -1.09965032932524 0.146487617911428 no 2900 0.135742252114631 4183 3107275
SGTC_2214 7179297 48.276 µM -1.10039933889361 0.146322931520053 no 2901 0.135579083206223 4234 769744
SGTC_2301 7769476 200 µM -1.10044977932822 0.14631184553976 no 2902 0.135568099779346 4214 977820
SGTC_2761 levamisole 97.89 µM -1.10065771055708 0.146266151620443 no 2903 0.135522829099045 4203 26879 An alkaline phosphatase inhibitor.
SGTC_517 1365-0151 113 µM -1.10133457457004 0.146117473772897 no 2904 0.135375534360503 4239 768657
SGTC_2478 5763493 32.33 µM -1.10183600985385 0.146007395538597 no 2905 0.135266486055978 4119 1365576 YLR208W SEC13
SGTC_1373 2887-0003 58.5 µM -1.10193732577048 0.145985160797884 no 2906 0.135244459961236 4145 776948
SGTC_2162 5663267 200 µM -1.10404168877245 0.145523852696366 no 2907 0.1347875270084 4199 6456493
SGTC_423 5-fluorouracil 457 µM -1.10618659916671 0.145054665853718 no 2908 0.134322880959831 4132 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1969 st069479 40.1 µM -1.10712906533709 0.144848829125175 no 2909 0.134119065348017 4194 3895485
SGTC_1434 4073-0095 163 µM -1.10905601024563 0.144428592436632 no 2910 0.133703010106038 4157 24133745
SGTC_13 0199-0087 65 µM -1.10910331246806 0.144418286900501 no 2911 0.133692808043602 4279 4589825
SGTC_2031 5180455 200 µM -1.10935312254846 0.14436387004874 no 2912 0.133638938309602 4165 29949
SGTC_1995 st072814 61.1 µM -1.10946008241542 0.144340574897502 no 2913 0.133615877753014 4170 5769371
SGTC_3145 9085516 49.47 µM -1.1112763205242 0.143945397023429 no 2914 0.133224714345336 4222 25236195
SGTC_363 0455-0021 3.06 µM -1.11173822320922 0.143845012542175 no 2915 0.133125360120628 4159 4597466
SGTC_2460 5552655 174.22 µM -1.11266368402294 0.143644025942153 no 2916 0.132926449061632 4238 5401989
SGTC_641 4092-0595 30 µM -1.11725843547933 0.142648969740251 no 2917 0.131941920861676 4244 786260
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.11750484781215 0.142595737780281 no 2918 0.131889263982781 4206 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2887 9044784 58.44 µM -1.11888077411637 0.142298746123151 no 2919 0.131595503026019 4176 6465546
SGTC_1220 1838-0075 193 µM -1.11989064363015 0.142081033777383 no 2920 0.131380182938071 4112 5529645
SGTC_8 0354-0001 70 µM -1.12222377303613 0.141578909469604 no 2921 0.130883653570477 4199 4993152
SGTC_74 000s-0487 160.283 µM -1.12552303968814 0.140870912375378 no 2922 0.130183729845037 4102 677548
SGTC_3123 9126162 49.47 µM -1.12562160791608 0.140849797412941 no 2923 0.130162858985268 4280 25239884
SGTC_876 0720-0963 56.8 µM -1.12805787106889 0.140328591468707 no 2924 0.129647739809133 4236 765861
SGTC_105 0111-0055 734.78 µM -1.12860769123379 0.140211146174895 no 2925 0.129531682363491 4229 5179370
SGTC_2618 avocadyne 43.43 µM -1.12923127818122 0.140078024623629 no 2926 0.129400141168068 4135 3015189
SGTC_3007 9078383 71.4286 µM -1.13014066697555 0.139884044885366 no 2927 0.129208478096052 4206 6496995
SGTC_2375 9072683 200 µM -1.13040216167651 0.139828299835223 no 2928 0.129153401837068 4303 16798029
SGTC_2152 5568786 200 µM -1.13379249712548 0.139106920184161 no 2929 0.128440799474888 4224 5399883
SGTC_3152 9099253 49.47 µM -1.13380115178941 0.139105081932817 no 2930 0.128438983881762 4136 25236131
SGTC_1331 1472-0049 76.2 µM -1.14042496020312 0.137703031659978 no 2931 0.127054649483802 4178 24051409
SGTC_1154 4088-0362 150 µM -1.14044860369997 0.137698044415981 no 2932 0.127049726811457 4237 6618304
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.1414749523203 0.137481670249345 no 2933 0.126836164778169 4267 688664
SGTC_1075 aripiprazole 15.2 µM -1.14253216126554 0.137259032948708 no 2934 0.126616442788689 4297 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1391 3442-0225 151 µM -1.14362951602566 0.137028201936947 no 2935 0.126388657748166 4204 5227075
SGTC_1590 st077108 57.8 µM -1.14459194308565 0.136825971716801 no 2936 0.12618911568053 4252 5489485
SGTC_1581 himbacine 57.9 µM -1.1468057016787 0.136361579779996 no 2937 0.125730966109276 4239 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3209 9113616 49.47 µM -1.14706595730044 0.136307055491765 no 2938 0.125677181095298 4294 16649353
SGTC_2224 6650123 117.647 µM -1.14889856225717 0.135923541919452 no 2939 0.125298905285852 4250 2908370
SGTC_626 0214-0009 33 µM -1.15007678146338 0.135677363757538 no 2940 0.125056124247163 4293 3437874
SGTC_3207 9114163 49.47 µM -1.1515780200687 0.135364136379304 no 2941 0.124747258895339 4269 849233
SGTC_194 1486-1323 56.904 µM -1.15224326903934 0.135225493466469 no 2942 0.12461056094239 4325 5178754
SGTC_3111 9122088 49.47 µM -1.1526477590414 0.135141242301483 no 2943 0.124527495965384 4090 16876704
SGTC_87 0100-0052 35.5 µM -1.15467894129914 0.134718711864743 no 2944 0.124110963146057 4285 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_164 4100-3994 89.624 µM -1.15485730638542 0.134681651363199 no 2945 0.124074432583023 4232 4615967
SGTC_1777 st045864 34.765 µM -1.1549103836183 0.134670624385021 no 2946 0.124063563403732 4235 4691462
SGTC_2993 9054257 71.4286 µM -1.15821450453653 0.133985401456991 no 2947 0.123388255319145 4169 6470217 YGL055W OLE1
SGTC_3284 9108171 64.8615 µM -1.15848247509382 0.133929933777981 no 2948 0.123333599648646 4229 8687505
SGTC_3285 9112818 20.8695 µM -1.15946658912168 0.133726365753441 no 2949 0.123133023840672 4226 17017947 YPR165W RHO1
SGTC_3056 9094900 49.47 µM -1.15983532928395 0.133650145149744 no 2950 0.123057928499351 4231 25236784
SGTC_1833 st055984 71 µM -1.15984822135798 0.133647480828235 no 2951 0.123055303560235 4246 676288
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.16238499672336 0.133123932348616 no 2952 0.122539557412571 4300 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_963 1269-2853 151 µM -1.16490415711767 0.132605417889749 no 2953 0.12202889529275 4233 3668223
SGTC_584 0986-0246 15.4 µM -1.16502748510294 0.132580069274999 no 2954 0.122003933755298 4351 53315 YDR232W HEM1
SGTC_2400 5203494 178.7 µM -1.167423744244 0.132088208937584 no 2955 0.121519643431291 4158 6777674
SGTC_758 0868-0029 16 µM -1.17150168821024 0.131254058720604 no 2956 0.120698589817994 4269 762687
SGTC_1620 st003704 16.5 µM -1.17485670889335 0.130570516881424 no 2957 0.120026023889507 4250 2834414
SGTC_2666 tannic acid 100 µM -1.17496304486963 0.13054889262739 no 2958 0.120004750466943 4252 16134267 A thiamine antagonist.
SGTC_1539 benzyladenosine 56 µM -1.17596881006671 0.130344484875761 no 2959 0.119803669965921 4256 92208 A nucleotide analog.
SGTC_601 0986-0029 62.9 µM -1.17972250165468 0.12958355504517 no 2960 0.11905530067703 4210 24747981
SGTC_2317 5986382 200 µM -1.17998358875529 0.129530743454427 no 2961 0.119003371078117 4292 877883
SGTC_3113 9123498 49.47 µM -1.18101460523602 0.129322339530005 no 2962 0.11879846066093 4381 8897275
SGTC_2644 guaiazulene 100 µM -1.18140291686954 0.129243908656944 no 2963 0.118721349918876 4282 3515 A coloring agent.
SGTC_2641 levomentholum 100 µM -1.18173001424574 0.129177867379629 no 2964 0.118656422518693 4257 16666
SGTC_1903 st060211 78.3 µM -1.18209232602383 0.129104743591917 no 2965 0.118584534503151 4295 688960
SGTC_301 4119-0100 24.5 µM -1.18630175780421 0.128257275951473 no 2966 0.117751576357717 4294 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2449 5812982 45.77 µM -1.18715661758235 0.12808564351757 no 2967 0.117582924622541 4203 776185
SGTC_380 3970-0968 6 µM -1.18777738463558 0.127961110523554 no 2968 0.117460563287498 4150 2891601
SGTC_2552 juarezic acid 87.02 µM -1.18807103748489 0.127902229711266 no 2969 0.117402711879756 4223 1549512
SGTC_2150 5556613 200 µM -1.19065143791328 0.127385638922804 no 2970 0.116895224737256 4292 743190
SGTC_1657 st012939 43.4 µM -1.19072789565149 0.127370354410961 no 2971 0.116880211554403 4287 24207257
SGTC_747 3448-8087 38.7 µM -1.19186626159069 0.127142936845188 no 2972 0.116656844533745 4343 5168703
SGTC_1294 1000-1494 117 µM -1.19222673735152 0.127070981573658 no 2973 0.116586176116543 4271 712797 YDL207W GLE1
SGTC_1563 conessine 56.1 µM -1.19380178308261 0.126756916061629 no 2974 0.1162777570128 4360 441082 An anti-amoebic, histamine inhibitor.
SGTC_3185 9108267 49.47 µM -1.19478972230268 0.126560196164517 no 2975 0.116084598436695 4281 4910486
SGTC_508 roscovitine 141 µM -1.19705853361487 0.126109232392382 no 2976 0.115641870420992 4341 160355 A CDKinase inhibitor.
SGTC_225 nsc-122657 1.016 µM -1.19867940749093 0.125787743693171 no 2977 0.115326314096195 4285 275685
SGTC_2408 sulbentine 18.36 µM -1.19938145469184 0.125648675247613 no 2978 0.115189827675449 4188 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1272 0839-0021 27 µM -1.20078021664254 0.125371914532995 no 2979 0.114918233948151 4299 5027250
SGTC_1407 3909-7909 12.3 µM -1.20199574041534 0.125131755351476 no 2980 0.114682589213728 4296 4411780
SGTC_1941 st076221 61.8 µM -1.20256597456349 0.125019201150031 no 2981 0.114572160641652 4166 2828568
SGTC_2371 9071574 200 µM -1.20602211242385 0.124338533460245 no 2982 0.113904482229552 4287 45596039
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.20659829762127 0.124225309434799 no 2983 0.113793441346416 4290 3256 An antibiotic and ribosome inhibitor.
SGTC_1254 0550-0035 264 µM -1.20924220235974 0.123706690298354 no 2984 0.11328490428007 4298 15121435
SGTC_103 0844-0104 51.839 µM -1.21166481808042 0.123232811076732 no 2985 0.1128203558377 4153 5375804
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.21393220770152 0.122790448841451 no 2986 0.112386806347758 4297 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2154 5570129 200 µM -1.21410383323447 0.122757010510269 no 2987 0.112354038212416 4343 673366
SGTC_2537 larixol 68.93 µM -1.21507398961402 0.122568112042842 no 2988 0.11216893646719 4276 6708759
SGTC_353 1988-1175 58.3 µM -1.21546356873313 0.122492314785825 no 2989 0.112094667786218 4134 2788357
SGTC_1432 4049-0298 68.4 µM -1.22142384190589 0.12133677216826 no 2990 0.110962792313868 4324 741646
SGTC_703 3875-0075 71.8 µM -1.22643810781823 0.120370589845958 no 2991 0.110016926432841 4359 2850814
SGTC_1768 st044301 37.178 µM -1.22813528089279 0.120044798019045 no 2992 0.109698094387321 4311 3931349
SGTC_3236 9132701 49.47 µM -1.22959787956646 0.119764534411255 no 2993 0.109423862234078 4303 24282524
SGTC_3257 9139206 32.98 µM -1.23154783148555 0.119391602099339 no 2994 0.109059019364613 4310 4910041
SGTC_3316 9136639 10.545 µM -1.23420887758351 0.11888399480095 no 2995 0.108562540111641 4304 4903665
SGTC_1462 k081-0014 26.5 µM -1.23649098732772 0.118449887093545 no 2996 0.108138056892684 3790 3270634
SGTC_3325 9138760 55.175 µM -1.23659956245905 0.11842926166114 no 2997 0.108117891220809 4252 43844959
SGTC_1483 3453-0561 55.9 µM -1.24511689653386 0.116819173365859 no 2998 0.106544392042634 4353 4546991
SGTC_2529 gangaleoidin 93.61 µM -1.24695911573605 0.116472977135639 no 2999 0.106206244471705 4337 4565183
SGTC_85 0868-0259 160.055 µM -1.25140114320222 0.115641210488231 no 3000 0.105394080206004 4243 83173
SGTC_2465 5809242 33.21 µM -1.25143374544095 0.115635121379434 no 3001 0.10538813598424 4375 2731748
SGTC_420 mitomycin C 81.9 mM -1.25311562104262 0.115321306949423 no 3002 0.105081815933798 4314 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1023 4482-3888 16 µM -1.25692157524183 0.114613405170227 no 3003 0.104391017563592 4357 3303168
SGTC_623 k072-0108 16.9 µM -1.25985302083775 0.114070272930704 no 3004 0.103861194378638 4305 5382803
SGTC_3179 9107801 49.47 µM -1.25991134923358 0.114059484600337 no 3005 0.103850672056216 4329 4818259
SGTC_3334 9142812 21.919 µM -1.26987977493996 0.112226404101588 no 3006 0.102063729254293 4351 45283678
SGTC_866 0495-0101 262 µM -1.27033551694566 0.112143104536893 no 3007 0.101982570949429 4326 635694
SGTC_63 0099-0242 26.702 µM -1.27447454504751 0.111388604512182 no 3008 0.10124764414499 4359 3898502 YLR359W ADE13
SGTC_1588 farnesol 29.9 µM -1.27763642310117 0.110814681324217 no 3009 0.100688825842456 4366 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3054 9094397 49.47 µM -1.2780238930188 0.110744496339671 no 3010 0.100620500911028 4343 2598354
SGTC_335 4077-0256 27.6 µM -1.27908370078727 0.110552689089046 no 3011 0.10043379132181 4289 3121989
SGTC_7 0192-1582 4.227 µM -1.2795390545224 0.11047035095633 no 3012 0.100353647945974 4393 252616
SGTC_2683 piperine 63.03 µM -1.28098497132433 0.110209188353384 no 3013 0.1000994724453 4355 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3080 9117754 49.47 µM -1.28342618493146 0.109769260013941 no 3014 0.0996714024900638 4344 9550191
SGTC_1135 dihydrocapsaicin 536.708 nM -1.28368573625733 0.10972256080323 no 3015 0.099625968614382 4261 107982 A Capsaicinoid.
SGTC_142 0335-0849 62.6745 µM -1.28550314048182 0.10939596780764 no 3016 0.0993082600073956 4328 3889043 YPR107C YTH1
SGTC_1697 st025554 27.742 µM -1.29001724196377 0.1085877927078 no 3017 0.0985223358393826 4373 1269519
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.29150094178364 0.108323100919992 no 3018 0.0982650143751586 4433 4213774
SGTC_3114 9122766 49.47 µM -1.29508122463028 0.107686291917387 no 3019 0.097646105532221 4369 17176985
SGTC_1631 benzylvanillin 81.9 µM -1.29515384036915 0.107673404044513 no 3020 0.0976335823883425 4413 75506
SGTC_2299 7976368 114.88 µM -1.29543199968741 0.107624046489218 no 3021 0.0975856225657326 4383 2979718
SGTC_2977 9011197 71.43 µM -1.29634590679979 0.107461994414367 no 3022 0.0974281696698819 4410 2704722
SGTC_669 0108-0021 26.2 µM -1.29899748594678 0.106992817515335 no 3023 0.09697239597763 4385 17201
SGTC_2674 ligustilide 100 µM -1.29899928110841 0.106992500376357 no 3024 0.0969720879426328 4414 5319022 A signalling regulator.
SGTC_2437 5741531 144.16 µM -1.30121764276563 0.106601115522712 no 3025 0.0965919839758452 4385 2262990
SGTC_1098 clofazimine 15.1 µM -1.3073414215377 0.105526065671667 no 3026 0.0955483911855573 4424 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2642 cholecalciferol 100 µM -1.30914125120775 0.105211595520765 no 3027 0.095243254087515 4362 9821465 A vitamin D precursor, similar to steriods.
SGTC_1765 st044815 90.4 µM -1.31071325227544 0.104937487333851 no 3028 0.0949773298384536 4405 645695
SGTC_1251 0490-5699 265 µM -1.31441908309893 0.104293352241386 no 3029 0.0943526060181381 4399 3883818
SGTC_847 0342-0274 5.54 µM -1.31449626558851 0.104279967170845 no 3030 0.0943396269931685 4367 18097
SGTC_3100 9120536 49.47 µM -1.31559074794735 0.104090294854509 no 3031 0.0941557202884077 4259 16421196
SGTC_1112 tnp00069 1.16933 µM -1.31560709667783 0.104087463538843 no 3032 0.0941529752050209 4375 145826
SGTC_2938 9059746 27.26 µM -1.31575589760376 0.104061696374306 no 3033 0.0941279930464839 4381 6471769
SGTC_361 000s-0510 1.45 µM -1.31823648158394 0.103632826189304 no 3034 0.0937122483087445 4284 660
SGTC_982 1491-0518 27.5 µM -1.31890652454265 0.103517202225008 no 3035 0.0936001823176401 4313 3091256
SGTC_1731 st035964 63 µM -1.31916623005531 0.103472412103852 no 3036 0.0935567726865054 4294 6739575
SGTC_29 0299-0004 12.984 µM -1.32483433516462 0.102498363294569 no 3037 0.0926130520003607 4286 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1917 st066507 28.5 µM -1.32597652148065 0.102302891295249 no 3038 0.0924237371963712 4331 3156428
SGTC_457 grayanotoxin iii 135 µM -1.32782883182454 0.101986466371289 no 3039 0.0921173299179124 4226 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_125 0133-0007 11.75 µM -1.32902589838367 0.101782354102878 no 3040 0.0919197128437571 4467 26541
SGTC_2735 sertaconazole 140 nM -1.33042181406664 0.10154471176344 no 3041 0.0916896656116719 4535 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1111 tnp00062 510.699 nM -1.33092939759102 0.10145840039935 no 3042 0.0916061215674485 4413 676306
SGTC_832 4083-0019 164 µM -1.33250010721205 0.10119164972204 no 3043 0.0913479531275881 4470 1990758
SGTC_2873 9040596 71.43 µM -1.33262582442455 0.101170321513388 no 3044 0.0913273130545816 4353 6463863
SGTC_2117 5521686 200 µM -1.33566532429912 0.100655660171437 no 3045 0.09082934405455 4372 803312
SGTC_99 0109-0120 622.8 µM -1.34033310531093 0.0998690135465693 no 3046 0.0900685365962109 4403 759414
SGTC_970 1315-0089 19.5 µM -1.3418069516702 0.0996215660084032 no 3047 0.0898292988140344 4358 6811083 YLR033W RSC58
SGTC_1713 st033146 12.748 µM -1.34758266288943 0.0986561859768341 no 3048 0.0888963249287134 4392 674619
SGTC_1574 spiramycin 23.7 µM -1.34870368429731 0.0984696092590967 no 3049 0.0887160808326693 4363 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1241 0364-0022 50.8 µM -1.3491523578928 0.0983950069002536 no 3050 0.088644016895934 4390 4563895
SGTC_2855 9016525 58.44 µM -1.34948456351454 0.09833979670837 no 3051 0.0885906876206015 4343 43811474
SGTC_2442 5158906 48.48 µM -1.35080010826081 0.0981213854168988 no 3052 0.0883797367053846 4414 1893835
SGTC_720 r052-1644 49.9 µM -1.35295513415687 0.0977643688390698 no 3053 0.0880349820243042 4417 1422863 YOR257W CDC31
SGTC_3329 9141233 27.5565 µM -1.35328080442684 0.097710498973263 no 3054 0.0879829695916878 4364 4909101 YNL103W MET4
SGTC_431 k089-0097 107 µM -1.35903768991651 0.0967618291261401 no 3055 0.0870673229136383 4144 5499420
SGTC_2776 terbinafine 19.92 µM -1.36360556191556 0.0960139215195341 no 3056 0.0863458703323284 4421 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2572 astragaloside iv 100 µM -1.36480597489756 0.0958180824874251 no 3057 0.0861570201985662 4414 45006101 An anti-inflammatory agent.
SGTC_542 3381-0244 89.3 µM -1.3663272555233 0.0955703184731394 no 3058 0.0859181349665207 4430 1112843
SGTC_1356 1502-0781 85.8 µM -1.36675415269288 0.095500876472181 no 3059 0.0858511888617714 4411 567702
SGTC_14 0354-0009 295 µM -1.36866472734145 0.0951905443764587 no 3060 0.0855520504499777 4498 1713507
SGTC_278 4092-0821 23.9 µM -1.36986985457349 0.0949951794710917 no 3061 0.0853637656914676 4411 877900
SGTC_2100 5377183 190 µM -1.37028948019481 0.0949272227344209 no 3062 0.0852982778000502 4443 2844202
SGTC_1504 k297-0033 30 µM -1.37043969331372 0.0949029050114871 no 3063 0.0852748442913024 4299 4388117
SGTC_1936 st074407 74.3 µM -1.37055581026188 0.0948841101997859 no 3064 0.0852567331501803 4439 809813
SGTC_2250 alverine citrate 130 µM -1.37146043128816 0.0947377811849522 no 3065 0.0851157351138315 4285 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1898 st060199 18.6 µM -1.37379900917365 0.0943602700532772 no 3066 0.0847520444156334 4398 688866
SGTC_868 0527-0199 213 µM -1.37606687780367 0.0939952340281811 no 3067 0.0844004644801125 4385 2849450
SGTC_95 0471-0001 561.058 µM -1.37791594702511 0.093698379957832 no 3068 0.0841146203714969 4416 4015405
SGTC_1679 SEC14.276 6.7 µM -1.3808534953903 0.0932282029926273 no 3069 0.0836620056270555 4401 1005053 YMR079W SEC14
SGTC_1966 st070145 16.1 µM -1.38367161294665 0.0927787824904817 no 3070 0.0832295147244853 4402 3748532
SGTC_903 1134-0042 114 µM -1.38831577611752 0.092041651415879 no 3071 0.0825204551763856 4427 701009
SGTC_2399 5884133 200 µM -1.39312365821755 0.0912831122537132 no 3072 0.0817912000379545 4390 722445
SGTC_1443 4112-3303 14 µM -1.39362652570888 0.0912040434136731 no 3073 0.081715207047746 4473 704433
SGTC_158 k038-0087 26.446 µM -1.39511811008253 0.0909698114906276 no 3074 0.0814901129232347 4346 X158
SGTC_2049 5262831 67.185 µM -1.4019907068128 0.0898963317370903 no 3075 0.0804590109086412 4399 763417
SGTC_1249 0481-0015 10.2 µM -1.40368635371758 0.0896329303836602 no 3076 0.0802061339063651 4374 4227577
SGTC_1640 st009078 66.4 µM -1.40487540325206 0.0894485663215258 no 3077 0.080029165948414 4411 690618
SGTC_2021 4019055 173 µM -1.40669667816504 0.0891667217881123 no 3078 0.0797586755932492 4226 44827708 YER133W GLC7
SGTC_1300 1094-0077 113 µM -1.4168420937159 0.0876087904754315 no 3079 0.0782645498331949 4418 5532636
SGTC_2824 7998404 51.95 µM -1.41693776783587 0.0875941960412801 no 3080 0.078250561540238 4410 837851
SGTC_721 1187-1332 279 µM -1.41797142751121 0.087436633973577 no 3081 0.0780995534202275 4430 25730
SGTC_1383 3049-0032 20.7 µM -1.42642163302202 0.0861564836811905 no 3082 0.076873336462283 4499 712864
SGTC_261 5-fluorouridine 15.376 µM -1.4298310630438 0.0856439659572263 no 3083 0.0763827556871655 4473 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_224 benfluorex 43.875 µM -1.43177339862132 0.0853530096018642 no 3084 0.0761043413144076 4463 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1448 4255-0083 152 µM -1.43354402561701 0.0850884204345427 no 3085 0.0758512133600643 4476 5399660
SGTC_126 0417-1624 672.48 µM -1.4367053508022 0.0846175450529734 no 3086 0.0754008669648706 4505 41912 YDL195W SEC31
SGTC_2862 9027634 71.43 µM -1.43746827550386 0.0845042016906709 no 3087 0.0752924904321702 4419 5012562
SGTC_23 0213-0011 39.996 µM -1.44000025557342 0.0841288560994847 no 3088 0.074933663380927 4453 627608
SGTC_2832 7992762 51.95 µM -1.44033562711728 0.084079233988972 no 3089 0.0748862332061133 4398 2985177
SGTC_2036 5160441 105 µM -1.44240017096198 0.0837742446684101 no 3090 0.0745947578296164 4427 134534 YIL048W NEO1
SGTC_2719 novobiocin 32.65 µM -1.44706893934319 0.0830876061058445 no 3091 0.0739388081534838 4504 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_172 1112-0046 2.638 µM -1.44947818066298 0.0827349372841869 no 3092 0.073602044704602 4444 2802135 YIL048W NEO1
SGTC_3304 9125678 46.087 µM -1.45061527372941 0.0825688794811394 no 3093 0.0734435099068029 4417 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2147 5545932 89.7195 µM -1.45233660644279 0.0823179785266435 no 3094 0.0732040168312702 4522 797404
SGTC_795 0685-0265 78 µM -1.45422785283168 0.0820429734206776 no 3095 0.0729415726625661 4466 302754
SGTC_950 1165-0508 94.1 µM -1.4596263063266 0.0812617953007236 no 3096 0.0721964026671526 4453 6148369
SGTC_109 0132-0036 33.701 µM -1.46089515898198 0.0810790042886638 no 3097 0.0720221076805181 4361 67274 A color developer.
SGTC_2432 5630864 12.22 µM -1.47142101291645 0.0795745953226552 no 3098 0.0705886470851629 4480 5714970
SGTC_468 gf-109203x 121 µM -1.47447811173565 0.0791416417463914 no 3099 0.0701764533941968 4549 2396 A protein kinase C inhibitor.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.47975699805748 0.0783982361761941 no 3100 0.06946905420249 4489 688667
SGTC_1270 0831-1170 17.3 µM -1.48328169818219 0.0779048217093775 no 3101 0.0689997914100622 4500 6764716
SGTC_583 1488-1091 88.9 µM -1.48349479359635 0.0778750666989992 no 3102 0.0689714993516369 4586 4303273
SGTC_463 ikarugamyin 104 µM -1.48418360579167 0.0777789452383043 no 3103 0.0688801089220921 4640 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_787 4152-0075 138 µM -1.48587884351134 0.0775427639942325 no 3104 0.0686555852826996 4513 9566539
SGTC_3295 9122362 53.5725 µM -1.49095743291299 0.0768384720649406 no 3105 0.0679863355245481 4470 4730473
SGTC_2062 5245942 200 µM -1.50134369252802 0.0754132771241429 no 3106 0.0666333447617813 4524 1376160
SGTC_2566 crystal violet carbinol 226 nM -1.50147269259085 0.0753957033712481 no 3107 0.0666166722547246 4453 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1463 k081-0032 34.1 µM -1.50183722721688 0.0753460594817642 no 3108 0.0665695757302786 4015 977755
SGTC_811 0416-0114 265 µM -1.50704174313722 0.0746400007487517 no 3109 0.0658999789007744 4517 6612453
SGTC_2092 5303694 80.6725 µM -1.51569446249341 0.0734773410586056 no 3110 0.0647983142553799 4513 1963699
SGTC_1824 st053723 68.6 µM -1.5159104608134 0.0734484957186318 no 3111 0.0647709974103015 4526 675225
SGTC_1675 st018485 24.5 µM -1.52044389445774 0.0728450780047751 no 3112 0.0641997247992783 4507 3323024
SGTC_2082 5219693 150 µM -1.52280790595273 0.0725319281090544 no 3113 0.0639033857237862 4464 2834649
SGTC_1647 st011722 22.4 µM -1.52376907701414 0.0724049013923646 no 3114 0.0637832033945237 4489 2854783
SGTC_2087 5276107 200 µM -1.52807407819592 0.0718380502809209 no 3115 0.0632470732955956 4489 144405
SGTC_1916 st067606 49.2 µM -1.53033445023923 0.0715417868436939 no 3116 0.0629669825588337 4400 19590279
SGTC_1741 st038134 10.228 µM -1.53285527813165 0.0712124926390168 no 3117 0.0626557585108239 4535 1272587
SGTC_1269 0831-0796 3.05 µM -1.53572116774926 0.0708395381506193 no 3118 0.0623033905940466 4544 927758
SGTC_3355 9151058 44.0485 µM -1.539841836615 0.0703059244407778 no 3119 0.0617994556233466 4538 17015728
SGTC_1984 st072354 53.1 µM -1.54100200352258 0.0701562454933297 no 3120 0.0616581491844725 4401 5762938
SGTC_965 1291-5240 308 µM -1.54160618255278 0.0700783944498721 no 3121 0.0615846611280223 4511 2834598
SGTC_178 4092-0806 87.505 µM -1.54526995579074 0.0696077243485693 no 3122 0.0611404897218573 4401 2169044
SGTC_2264 7948757 110.76 µM -1.55523373710011 0.0683400267080054 no 3123 0.0599452060651397 4496 2971411
SGTC_36 0335-0881 14.2 µM -1.55543503098143 0.0683146008002315 no 3124 0.0599212482427844 4420 23828853
SGTC_1157 4092-0394 27.6 µM -1.55688025650887 0.0681322652334567 no 3125 0.0597494589047737 4572 3659885
SGTC_3341 9147222 25.867 µM -1.55850558790007 0.0679276558344666 no 3126 0.0595567222043668 4529 1939759
SGTC_3276 9139060 49.47 µM -1.55928622518909 0.0678295519497873 no 3127 0.0594643252605358 4606 4870619
SGTC_2468 5987765 72.9 µM -1.55999515289446 0.0677405547634027 no 3128 0.0593805133178383 4564 26772094
SGTC_980 1473-0395 201 µM -1.56086225794148 0.0676318230151454 no 3129 0.0592781270326069 4446 768876
SGTC_1349 flufenamic acid 69 µM -1.56156323340003 0.0675440219035924 no 3130 0.0591954582746686 4469 3371 A non-steroidal anti-inflammatory.
SGTC_2695 st077686 51.995 µM -1.56312194576218 0.0673491001336918 no 3131 0.0590119573365985 4486 2876092
SGTC_739 1486-1183 203 µM -1.56555630590465 0.0670455461195977 no 3132 0.0587262629675744 4519 4346692
SGTC_2553 4-methylesculetin 85.09 µM -1.56625253195218 0.0669589246691058 no 3133 0.0586447544471345 4531 5319502
SGTC_1883 5-benzylidenerhodanine 20 µM -1.57458262573018 0.0659292325388844 no 3134 0.0576764079130426 4518 1273210
SGTC_2359 9039622 200 µM -1.57759380359638 0.065560051830606 no 3135 0.0573294784106604 4492 6463596
SGTC_2297 7971671 152.32 µM -1.58121991290274 0.065117608245739 no 3136 0.0569138819222815 4533 909016
SGTC_2142 5622915 118.518 µM -1.58852684949332 0.0642330873448521 no 3137 0.0560836273173514 4554 5322196
SGTC_3348 9149464 3.537 µM -1.59473560027533 0.0634888674773829 no 3138 0.0553856867557028 4494 1951442
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.59508600570107 0.0634470665819502 no 3139 0.0553465022234582 4619 688664
SGTC_1954 st077032 68.9 µM -1.59887998741341 0.0629958417865635 no 3140 0.0549236357848059 4485 698907
SGTC_2865 9030313 51.95 µM -1.60060150596927 0.0627919248321594 no 3141 0.0547326042548689 4526 42562754
SGTC_3021 9087658 49.47 µM -1.60352062506048 0.0624473259348243 no 3142 0.054409879643602 4569 25237042
SGTC_661 1304-0007 33.6 µM -1.60556878645269 0.0622064241958275 no 3143 0.0541843441212783 4565 3117130
SGTC_2364 9055074 200 µM -1.60658360113998 0.0620873320561784 no 3144 0.0540728711150325 4540 6470630
SGTC_2234 tolnaftate 200 µM -1.61120553581646 0.0615471801405996 no 3145 0.0535674658198709 4657 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1956 st077085 54 µM -1.61323647683624 0.0613109937172231 no 3146 0.0533465707092676 4583 24208685
SGTC_664 1222-0054 14.9 µM -1.62063837544799 0.0604561858788195 no 3147 0.0525476084994494 4528 6813991
SGTC_1033 k072-0102 21.3 µM -1.62579106547902 0.0598666535286324 no 3148 0.0519970548240648 4505 5965931
SGTC_1653 st012112 65 µM -1.62771627330893 0.0596475446915477 no 3149 0.0517925304462932 4532 720429
SGTC_2732 terfenadine 20 µM -1.62865275931163 0.0595411901912413 no 3150 0.0516932743150986 4637 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1439 4092-1168 46 µM -1.63110778603621 0.0592630841000713 no 3151 0.051433789040135 4578 2886240
SGTC_480 am 92016 50 µM -1.63337499331135 0.0590071598889961 no 3152 0.0511950765341712 4565 2129 K+ channel blocker.
SGTC_928 2764-0428 58.7 µM -1.63627524051611 0.0586810425078118 no 3153 0.0508909977802107 4573 662578
SGTC_2583 asiatic acid 100 µM -1.63639292959926 0.0586678389262989 no 3154 0.0508786889967842 4563 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_174 3553-0389 74.3 µM -1.6413985622366 0.0581084111268336 no 3155 0.0503573540752708 4582 738071
SGTC_221 trifluoperazine 10.304 µM -1.64443144097458 0.0577715022289362 no 3156 0.0500435575419625 4557 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_849 0386-0493 241 µM -1.64642900052403 0.0575504424915903 no 3157 0.0498377332333275 4596 726119
SGTC_809 3998-0021 90 µM -1.6464632652022 0.0575466564065353 no 3158 0.0498342085730185 4524 715485
SGTC_1756 st041558 35.5 µM -1.65672078593305 0.0564220297360646 no 3159 0.0487879692914158 4640 3955792
SGTC_2191 5911152 200 µM -1.65875141339384 0.0562014610716949 no 3160 0.0485829472695033 4595 2875902
SGTC_1265 0819-1001 68.8 µM -1.65910121027567 0.0561635345412287 no 3161 0.0485476997249034 4515 3106768
SGTC_1694 st024011 44.9 µM -1.66136063797092 0.0559190433282212 no 3162 0.0483205191222206 4607 2787533
SGTC_1187 1391-0724 117 µM -1.66209475332603 0.0558397861468314 no 3163 0.0482468887052124 4619 6997986
SGTC_1776 st049249 45.9 µM -1.66442014114478 0.0555893155729077 no 3164 0.0480142489121635 4588 1822314
SGTC_954 1189-0853 2.85 µM -1.66465644427996 0.0555639127681487 no 3165 0.0479906586723588 4514 2828194
SGTC_530 4358-1714 28 µM -1.66523182029657 0.0555020976354484 no 3166 0.0479332574396759 4560 1564641
SGTC_1431 4049-0260 9.09 µM -1.66848023180775 0.0551541246346079 no 3167 0.0476102164775298 4602 3854841
SGTC_2143 5623677 140.463 µM -1.67485104629438 0.0544766828868885 no 3168 0.0469817302589157 4561 5375313
SGTC_1182 1222-0449 220 µM -1.67750333323597 0.0541965989757915 no 3169 0.046722049102993 4591 658318
SGTC_83 0170-0301 39.027 µM -1.68071791788471 0.0538586647913389 no 3170 0.0464088592892627 4604 3089716
SGTC_60 0986-0278 202 µM -1.68430923206296 0.0534831023462721 no 3171 0.0460609610689728 4537 3110598
SGTC_1235 benzylparaben 21.5 µM -1.68539712880741 0.0533697457296796 no 3172 0.0459559886166846 4624 7180
SGTC_1688 st021091 57.6 µM -1.68948372219054 0.0529456312035958 no 3173 0.0455633843514554 4622 3656366
SGTC_598 3937-0236 20.2 µM -1.69288920605452 0.0525942492865923 no 3174 0.0452382791424791 4633 1379313
SGTC_316 k060-0003 58.6 µM -1.69764295790797 0.0521068492866679 no 3175 0.0447875849085436 4626 6152314
SGTC_170 4197-0004 226 µM -1.69788725377617 0.0520818989990409 no 3176 0.0447645217065643 4595 218692
SGTC_333 3486-0131 40.1 µM -1.700365594704 0.0518293186542429 no 3177 0.0445310895974593 4604 6744690
SGTC_3167 9103034 49.47 µM -1.70579028046481 0.0512798589328815 no 3178 0.0440235667047221 4656 5127859
SGTC_3070 9117005 49.47 µM -1.70858574044514 0.0509985250565867 no 3179 0.0437638559361429 4676 8779016
SGTC_2003 4023581 200 µM -1.71156472567985 0.0507000748797132 no 3180 0.0434884567797097 4594 16641307
SGTC_1016 4226-1401 38 µM -1.71164134047133 0.0506924175989907 no 3181 0.0434813924428138 4603 2901613
SGTC_1642 st009582 77.7 µM -1.71345912450024 0.0505110088309831 no 3182 0.0433140535498731 4589 6739311
SGTC_1450 4112-4260 37.6 µM -1.718504987868 0.0500101580047479 no 3183 0.0428522727253752 4584 1633175
SGTC_782 0083-0095 30.5 µM -1.71979744595977 0.0498825081845773 no 3184 0.042734633523254 4572 3591729 An indicator and reagent.
SGTC_2675 theaflavin digallate 100 µM -1.73148797049853 0.0487396632767877 no 3185 0.0416823842936798 4546 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2322 7413319 38.22 µM -1.73616162804557 0.0482886715423765 no 3186 0.0412676299839649 4535 1840400
SGTC_1011 4112-3381 17.4 µM -1.73786999021039 0.0481246560357121 no 3187 0.041116862298736 4628 2877139
SGTC_3349 9149703 23.001 µM -1.7429630494 0.0476383286379235 no 3188 0.0406700347258718 4616 4910494
SGTC_655 k060-0012 42 µM -1.74736954647898 0.0472207430750817 no 3189 0.0402866282359674 4612 5994525
SGTC_139 0099-0334 718.624 µM -1.74782091468922 0.0471781349458906 no 3190 0.0402475212790931 4595 97690
SGTC_2184 6075246 200 µM -1.74954996658959 0.047015201464981 no 3191 0.0400979998320855 4592 2267320
SGTC_2541 muurolladie-3-one 83.07 µM -1.75021948391625 0.046952232252174 no 3192 0.0400402240164062 4536 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1386 3228-0095 33.8 µM -1.7526183893927 0.0467271663501001 no 3193 0.0398337662898285 4612 870181
SGTC_2240 6690706 185.951 µM -1.75622195816549 0.0463907061688142 no 3194 0.0395252583816731 4507 805876
SGTC_2265 7929201 200 µM -1.75904285207089 0.0461286826926484 no 3195 0.0392851151785238 4585 1265108
SGTC_1726 st035556 14.5795 µM -1.77200724510985 0.0449397111684593 no 3196 0.0381966772810577 4637 5919439
SGTC_1130 3454-2858 15.9 µM -1.77630000715403 0.0445515005389757 no 3197 0.037841741026358 4574 715628 YIL048W NEO1
SGTC_2244 6635614 200 µM -1.78280214774516 0.0439686370486951 no 3198 0.0373092580176604 4563 836499
SGTC_877 0771-0151 33.1 µM -1.78416381456672 0.0438473570024956 no 3199 0.0371985251508343 4627 6166523
SGTC_2726 cimetidine 79.27 µM -1.78552785232638 0.0437261364807085 no 3200 0.0370878688694746 4650 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_597 k018-0003 82.8 µM -1.78931226322575 0.043391235353388 no 3201 0.0367822700916572 4661 6786234
SGTC_520 3584-0023 682 µM -1.80919917052442 0.0416652317270187 no 3202 0.0352100332316513 4601 1340790
SGTC_1094 duloxetine 25.4 µM -1.8128417940359 0.041355193537305 no 3203 0.0349281128829796 4640 60834 A selective serotonin reuptake inhibitor.
SGTC_690 glyoxal 20.3 µM -1.81328678819229 0.0413174468131179 no 3204 0.0348937999762055 4442 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1754 st042065 16.137 µM -1.81460839448441 0.0412055058852348 no 3205 0.034792055771635 4389 1126236 YIL048W NEO1
SGTC_2788 5282734 71.43 µM -1.82257233848344 0.0405361494501291 no 3206 0.0341840941625548 4638 743706
SGTC_3141 9094609 49.47 µM -1.82667162455045 0.0401950677513584 no 3207 0.0338745785555132 4583 25236309 YDL196W YDL196W
SGTC_2085 5307070 144.047 µM -1.83112519660016 0.0398271537294781 no 3208 0.0335409292467781 4580 2840351
SGTC_2805 7950783 58.44 µM -1.84145337591375 0.0389844628910125 no 3209 0.0327775735289986 4628 1178958 YDL195W SEC31
SGTC_1025 k007-0731 70 µM -1.84399925558039 0.0387789868419522 no 3210 0.0325916243340982 4615 6256118
SGTC_1763 st044482 94.5 µM -1.85236043931079 0.0381103604337663 no 3211 0.0319870410585355 4627 88505
SGTC_1712 st032288 53.4 µM -1.85430583881118 0.037956146984469 no 3212 0.0318477086338836 4435 2883011
SGTC_754 3474-0146 171 µM -1.85754269249926 0.0377006874621844 no 3213 0.0316169915656341 4632 24762078
SGTC_533 1222-0222 6.71 µM -1.85929542650116 0.0375629447084289 no 3214 0.0314926374564343 4668 3982874
SGTC_166 k072-0058 166.424 µM -1.86569790287991 0.0370632789889117 no 3215 0.0310418216253446 4523 5846229
SGTC_846 0335-0850 148 µM -1.88126528508151 0.0358709971186802 no 3216 0.0299679204138533 4650 6819598
SGTC_1658 st012944 20 µM -1.88991525472005 0.0352222073159948 no 3217 0.0293846475035619 4519 24207260
SGTC_714 4296-0578 26.1 µM -1.89132805806908 0.0351171603851643 no 3218 0.0292902827379892 4687 1589775
SGTC_1197 1601-0112 267 µM -1.89786641400477 0.0346343530692383 no 3219 0.0288568408375818 4635 7350313
SGTC_3250 9135583 49.47 µM -1.90488519090992 0.0341221515758312 no 3220 0.0283974983392175 4660 7699353
SGTC_1003 4049-0218 100 µM -1.91765522916549 0.0332062248658445 no 3221 0.0275773710741059 4661 295161
SGTC_2922 7999257 32.47 µM -1.92189056749749 0.0329069560121125 no 3222 0.0273097644780697 4641 2988377
SGTC_3298 9116858 71.43 µM -1.92974354534856 0.0323579476680371 no 3223 0.0268193107969323 4693 2506942
SGTC_2753 fluvastatin 17.09 µM -1.93313030978241 0.0321235199507868 no 3224 0.0266100735482183 4641 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2734 clemastine 41.6 µM -1.93457910489005 0.0320236651990975 no 3225 0.0265209830914643 4735 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_931 2812-0076 566 µM -1.93595432955416 0.0319291183622104 no 3226 0.0264366473766499 4612 3450959
SGTC_1303 1160-0052 261 µM -1.95510368787703 0.030636387057568 no 3227 0.025285416538266 4643 3562476
SGTC_339 3091-4833 71.4 µM -1.95714824791408 0.0305009610999139 no 3228 0.0251650206402724 4500 3240077
SGTC_1067 clotrimazole 1.36 µM -1.96222891256873 0.0301665781163187 no 3229 0.0248679196173361 4711 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1945 st075991 56.6 µM -1.96254469296584 0.0301458957901945 no 3230 0.0248495512958415 4661 1084980
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.96500626981995 0.0299850752029206 no 3231 0.0247067559383972 4678 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2047 4141938 200 µM -1.96926713636198 0.0297083846307175 no 3232 0.0244612114698559 4693 3807862
SGTC_122 0236-0016 402.397 µM -1.97108049158118 0.0295912740025209 no 3233 0.024357334880523 4662 6808838
SGTC_1480 1070-0044 41.2 µM -1.97738025881863 0.0291873946167048 no 3234 0.0239993318554153 4719 3124987
SGTC_901 1112-0062 60.1 µM -1.9896086129951 0.0284164994700031 no 3235 0.0233170333134825 4700 1908457
SGTC_1764 st044502 93.5 µM -1.99082165888938 0.0283409593866409 no 3236 0.0232502486645159 4695 8407
SGTC_433 pimozide 108 µM -1.99313880754423 0.0281971279197421 no 3237 0.0231231247663854 4624 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1900 st060200 72.8 µM -1.99657089441506 0.0279852063043404 no 3238 0.0229359086292137 4683 688945
SGTC_3188 9110789 49.47 µM -1.9978218419552 0.027908294442269 no 3239 0.0228679892385636 4657 849217
SGTC_2617 dihydrotanshinone i 20.83 µM -2.0010943083315 0.0277079261854038 no 3240 0.0226911138030896 4635 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_783 0848-0141 92.7 µM -2.00171383211436 0.0276701289442249 no 3241 0.0226577589434042 4645 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3067 9117431 49.47 µM -2.00551065006873 0.0274394220583528 no 3242 0.0224542416694411 4681 17150885
SGTC_2251 lansoprazole 556 µM -2.00667578681699 0.027368947049416 no 3243 0.0223920979115385 4674 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2939 9044578 71.43 µM -2.00745174429584 0.0273220959133283 no 3244 0.0223507919520683 4628 2653634
SGTC_1198 1612-1005 86.7 µM -2.01997345444513 0.0265752573934968 no 3245 0.0216930705519798 4713 6998509
SGTC_1819 st053448 58.6 µM -2.02409102931465 0.026333428163916 no 3246 0.0214803932292654 4662 2857616
SGTC_1429 4049-0205 9.46 µM -2.02658102625273 0.0261880826883953 no 3247 0.0213526392962782 4723 22774478
SGTC_848 0368-0089 85.6 µM -2.0266156304992 0.0261860675133444 no 3248 0.0213508683970085 4688 762535
SGTC_2372 9071633 200 µM -2.03149179729542 0.0259033979757379 no 3249 0.0211025653992547 4713 21321366
SGTC_2779 methotrexate 400 µM -2.03184518863695 0.0258830116100788 no 3250 0.0210846654279543 4669 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2897 9048598 12.99 µM -2.03328717767739 0.0257999655450504 no 3251 0.0210117589270119 4672 6467404
SGTC_2206 7254556 146.969 µM -2.03856982745195 0.0254976331690274 no 3252 0.0207464895592147 4715 4398905
SGTC_2033 5192550 145 µM -2.04092720874726 0.025363677933347 no 3253 0.0206290314384073 4689 182073
SGTC_3279 9140807 49.47 µM -2.05061425730057 0.0248193965259297 no 3254 0.0201522634161084 4731 45595718
SGTC_2347 9049783 174.81 µM -2.05515445152491 0.0245676902854494 no 3255 0.0199320444807857 4665 6467988 YPL169C MEX67
SGTC_2499 avocadenofuran 51.48 µM -2.05575710091445 0.0245344412920904 no 3256 0.0199029674693872 4656 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_390 dec-rvkr-cmk 16.7 µM -2.0602040195393 0.0242902643261429 no 3257 0.0196895204112076 4720 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3172 9105863 49.47 µM -2.06762446307555 0.0238873579903371 no 3258 0.0193376749466802 4773 2348785
SGTC_831 k061-1017 217 µM -2.09189709910208 0.0226084631043374 no 3259 0.0182238608270588 4729 1240153
SGTC_855 0428-0020 25 µM -2.09775238460142 0.0223087476154147 no 3260 0.0179635123593876 4715 6812414
SGTC_1285 0929-0069 65.5 µM -2.10122373676331 0.0221326467079885 no 3261 0.0178106653338042 4718 1206237
SGTC_227 fluconazole 33.516 µM -2.10629409391545 0.0218775378984499 no 3262 0.0175894070137724 4699 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_535 2293-4129 48.2 µM -2.10700824327669 0.0218418066353694 no 3263 0.017558432519617 4687 396118 YIL048W NEO1
SGTC_1492 4158-0558 28.5 µM -2.10823551156398 0.0217805174561929 no 3264 0.0175053114963876 4710 3967268
SGTC_154 3389-1638 511.116 µM -2.11507887918623 0.0214414203159718 no 3265 0.0172116125082216 4709 5238686
SGTC_200 k038-0079 37.545 µM -2.12008853976512 0.0211960243350896 no 3266 0.0169992896207948 4722 3436683
SGTC_293 4049-0273 38.5 µM -2.12221982384628 0.0210923469625166 no 3267 0.0169096412945798 4628 1380311
SGTC_3219 9131112 49.47 µM -2.13406163536205 0.0205240796228988 no 3268 0.0164188679016391 4588 17612988 YMR079W SEC14
SGTC_1800 st050079 29.0735 µM -2.13538734243437 0.0204612762632999 no 3269 0.0163646918672291 4567 3645560
SGTC_693 4161-2696 114 µM -2.13823014976092 0.0203271514374307 no 3270 0.0162490342562415 4734 805759
SGTC_2261 9010538 184.68 µM -2.15397699485826 0.019597632943375 no 3271 0.0156209880369567 4690 6457250
SGTC_2703 st077852 53.4 µM -2.1599160184804 0.0193283245156038 no 3272 0.0153895857393727 4716 6281836
SGTC_2713 st079149 53.4 µM -2.16002591420336 0.0193233710141235 no 3273 0.0153853317546563 4724 3103253
SGTC_2942 9052777 62.25 µM -2.18318746725939 0.0183031685243811 no 3274 0.0145110036603747 4710 6469503
SGTC_2701 st077767 14.721 µM -2.18508828928691 0.0182215187385149 no 3275 0.0144411868640091 4704 5721188
SGTC_921 1561-0023 372 µM -2.18574155190553 0.0181935296101546 no 3276 0.0144172595280997 4704 24050882
SGTC_1569 carminic acid 40.6 µM -2.19192095311443 0.0179305800298883 no 3277 0.0141926074184283 4740 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_357 1325-0123 420 µM -2.19358048157284 0.0178605173195916 no 3278 0.0141327914396223 4717 1098503
SGTC_582 0987-0078 156 µM -2.20010236669683 0.0175874311296815 no 3279 0.0138998165054928 4743 1625765
SGTC_347 4534-1311 26.2 µM -2.21062318914924 0.0171544134165838 no 3280 0.013530970784025 4723 2862016
SGTC_68 0986-0284 82.829 µM -2.21314776540915 0.01705187243602 no 3281 0.0134437299651331 4664 423278 YIL048W NEO1
SGTC_120 rhodamine 6G 52.259 µM -2.21403486482588 0.0170159656332778 no 3282 0.0134131903286264 4719 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_119 0121-0043 24.815 µM -2.22988900507792 0.0163850608927721 no 3283 0.0128774062512402 4720 1092378
SGTC_2765 myclobutanil 7.74 µM -2.25036296160826 0.0156000358192575 no 3284 0.0122129570830362 4717 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_62 0180-0423 3.232 µM -2.25296611841674 0.0155025749932123 no 3285 0.0121306426749519 4697 30102 YGL099W LSG1
SGTC_990 3985-0011 41.3 µM -2.27965933018445 0.0145329873850269 no 3286 0.0113139505847362 4720 5399565 YGL099W LSG1
SGTC_3098 9119039 49.47 µM -2.29683448745517 0.0139371121505284 no 3287 0.0108141066858348 4733 17161528
SGTC_962 1254-0300 21.5 µM -2.29730592499452 0.0139210575886995 no 3288 0.010800662020993 4729 7340576
SGTC_1194 1488-0194 225 µM -2.30019608009431 0.0138229829475923 no 3289 0.0107185569057573 4747 1391452
SGTC_1090 efavirenz 20.7 µM -2.30148446852957 0.013779455110601 no 3290 0.0106821311455919 4749 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_555 4296-0685 37 µM -2.30713049692076 0.0135900971257128 no 3291 0.010523773137924 4733 2908540 YHR072W ERG7
SGTC_1316 1272-0050 65.9 µM -2.30747069303055 0.0135787596227699 no 3292 0.0105142971054366 4739 7340392
SGTC_2571 chrysanthemic acid 100 µM -2.30863503716248 0.0135400180127966 no 3293 0.0104819209914667 4712 2743 An insecticide.
SGTC_482 fipronil 114 µM -2.31186579716301 0.0134330191247328 no 3294 0.0103925400442641 4790 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.31477684657736 0.0133372347317544 no 3295 0.0103125738356759 4720 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1022 4477-0945 21.3 µM -2.32332295350568 0.0130594362669876 no 3296 0.0100809048195422 4704 4648966
SGTC_3264 9137442 49.47 µM -2.32668715608052 0.0129514598953058 no 3297 0.00999096097467158 4708 17015726
SGTC_2011 4012611 177 µM -2.34039938720966 0.0125193039454687 no 3298 0.00963156395215767 4714 2049887
SGTC_792 4534-1957 155 µM -2.34984828886171 0.0122288277087812 no 3299 0.00939053210175842 4732 1717904
SGTC_532 1548-0774 215 µM -2.35822517150652 0.0119762095826719 no 3300 0.00918127546900589 4758 5932993
SGTC_1802 st050112 57.9 µM -2.37805121023897 0.011396285572606 no 3301 0.00870220431672641 4762 4662563
SGTC_2800 7887935 81.82 µM -2.38086228195314 0.0113160674310017 no 3302 0.00863608394592084 4730 2961002
SGTC_821 1114-0266 29.2 µM -2.38432521011352 0.0112179225563111 no 3303 0.00855523705555245 4759 3123235
SGTC_1826 st055655 41.6 µM -2.39901931344697 0.0108096552884914 no 3304 0.00821952380150311 4739 676168
SGTC_3326 9140064 16.379 µM -2.40509905412448 0.0106445535090609 no 3305 0.00808404137012824 4728 1868434
SGTC_2682 pyrogallin 40.03 µM -2.41600936291383 0.0103537747087392 no 3306 0.00784582892250723 4767 822798 An ATP competetive kinase inhibitor.
SGTC_217 ketoconazole 989 nM -2.43857565696574 0.00977424198589034 no 3307 0.00737263587004564 4625 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3037 9091026 49.47 µM -2.44170323886658 0.00969619989675076 no 3308 0.00730907877396987 4660 25236398 YIL048W NEO1
SGTC_551 k048-0028 34.9 µM -2.46510188546728 0.00912941589575591 no 3309 0.00684871483136562 4727 6836383
SGTC_1427 4048-4900 550 nM -2.48871218892451 0.00858711917115239 no 3310 0.0064103353287078 4766 24132586
SGTC_2838 9002687 71.43 µM -2.51112830283442 0.0080986149140996 no 3311 0.00601729740574647 4734 6457060
SGTC_660 4031-1742 102 µM -2.51116497003271 0.00809783627633019 no 3312 0.00601667239389812 4686 6738706
SGTC_1937 st074714 47.2 µM -2.52215232858253 0.00786745990790665 no 3313 0.00583195933566511 4738 17250970
SGTC_2137 5261020 140 µM -2.52713626290843 0.00776487426450553 no 3314 0.00574984377742997 4758 763655
SGTC_553 k007-0256 45.7 µM -2.55301855784341 0.00725083895253346 no 3315 0.00533969029823479 4781 6287000
SGTC_1947 st076332 61.6 µM -2.63430888794422 0.00582615486202303 no 3316 0.00421543753329773 4718 24208416
SGTC_1745 st081495 74 µM -2.66721641400038 0.00532401110313098 no 3317 0.00382412024488899 4694 13842402 YBL026W LSM2
SGTC_3200 9114385 49.47 µM -2.674173377042 0.00522291826756011 no 3318 0.00374568553676768 4744 17018030 YLR208W SEC13
SGTC_3000 9075062 71.4286 µM -2.67568543254168 0.00520117359099596 no 3319 0.00372883026192156 4769 17057871
SGTC_2404 5161160 200 µM -2.67929557757432 0.00514958199810658 no 3320 0.00368886181402507 4758 2831543
SGTC_3170 9103054 49.47 µM -2.68298827558911 0.00509728236532239 no 3321 0.00364837741839232 4761 16432970
SGTC_2304 7443016 91.4 µM -2.69026853989287 0.00499555531784007 no 3322 0.00356972711051595 4755 939854
SGTC_1572 epiandrosterone 68.9 µM -2.69280830281118 0.00496049503691244 no 3323 0.00354264970528842 4771 441302 A steroid.
SGTC_1417 3966-0327 90.4 µM -2.69376973701056 0.00494728017651655 no 3324 0.00353244769321871 4800 651118
SGTC_1046 2001-0062 216 µM -2.69663328483911 0.00490810650097219 no 3325 0.00350221800033904 4768 739778
SGTC_2774 tamoxifen 10.92 µM -2.69866440383125 0.0048804883528695 no 3326 0.00348091708490373 4774 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1108 betulinic acid 729.144 nM -2.70191213854792 0.00483661499262634 no 3327 0.00344709889298473 4750 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2133 5320837 200 µM -2.70858334193653 0.00474759553566255 no 3328 0.00337855693685423 4764 2841355
SGTC_991 3996-0057 64.7 µM -2.73366804476131 0.00442580387177317 no 3329 0.00313165769080739 4775 715343
SGTC_1051 3253-3903 78 µM -2.7388486631452 0.00436182587743979 no 3330 0.00308273733721952 4774 5509239
SGTC_2634 4'-methoxyflavone 100 µM -2.75474115845574 0.00417068682811778 no 3331 0.0029369292210131 4753 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2784 7567673 72.73 µM -2.78139604028545 0.00386687939217616 no 3332 0.00270628314752197 4741 3471247
SGTC_2592 piperlongumine 83.33 µM -2.87656274067865 0.00293739287458151 no 3333 0.00201016131878341 4768 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_197 4544-0043 41.561 µM -2.89344488043901 0.00279533623458281 no 3334 0.00190520581789719 4790 896523
SGTC_2758 dehydroepiandrosterone 69.35 µM -2.92312215246404 0.00256056452704697 no 3335 0.00173270268339583 4759 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3134 9127454 49.47 µM -2.93575383324171 0.00246616086201333 no 3336 0.0016636912854613 4787 24262820
SGTC_374 0880-0231 82.3 µM -2.95434890871063 0.00233291104416151 no 3337 0.0015666476923723 4725 6833587
SGTC_209 4077-0173 175.592 µM -2.97288118540068 0.00220663060346132 no 3338 0.00147509314487436 4760 15993494
SGTC_3009 9080819 71.4286 µM -2.9853952476106 0.00212489761271562 no 3339 0.00141606060213112 4800 17027216
SGTC_153 4077-0274 519.67 µM -3.03080384519692 0.00185086122610567 no 3340 0.00121951822070226 4785 3121976
SGTC_956 1185-0240 191 µM -3.07410598018348 0.0016198755060697 no 3341 0.00105567207204351 4782 1416193
SGTC_2757 clomiphene 4.22 µM -3.12918786281507 0.00136407337832629 no 3342 0.000876450993823081 4776 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2367 9070478 135.38 µM -3.1614315864011 0.00123202916001096 no 3343 0.000784978464131692 4787 572802
SGTC_2498 4'-Methoxychalcone 54.63 µM -3.19563092637977 0.00110484348967647 no 3344 0.000697627316858404 4793 641818 YHR062C RPP1
SGTC_151 3013-0144 2.285 µM -3.19816568405146 0.00109591337825008 no 3345 0.000691523966456626 4672 906558 YHR107C CDC12
SGTC_44 0929-0055 61.211 µM -3.20277203728219 0.00107985407233939 no 3346 0.000680558390128473 4691 1379590
SGTC_191 3914-0123 66.505 µM -3.24961827188357 0.000928359194885376 yes 3347 0.000577800067720172 4808 3144412
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -3.26852891522304 0.000872938924127368 yes 3348 0.000540540652729113 4774 676296 Flavone; oxidizing agent.
SGTC_2699 st077704 54.6 µM -3.31781860337078 0.000742474645490018 yes 3349 0.000453616911298743 4796 645852
SGTC_2305 7443522 69.23 µM -3.35093711990109 0.000665174582366389 yes 3350 0.000402692939908342 4776 5415886
SGTC_2624 nerol 100 µM -3.4818714660174 0.000426735600427652 yes 3351 0.000248961316882051 4783 637566 A natural product oil.
SGTC_1818 st052136 56.3 µM -3.5173947922392 0.00037735549973815 yes 3352 0.000217902536241414 4728 674169
SGTC_385 1494-0393 12.4 µM -3.83005773818172 0.000121959382578101 yes 3353 6.40565975850869e-05 4805 3090647
SGTC_2366 9070441 60.58 µM -4.05501891784397 5.13390458636949e-05 yes 3354 2.50651227417825e-05 4800 6837235
SGTC_2419 paclitaxel 166.5 µM -5.02221206817105 7.50224757344169e-07 yes 3355 2.55398691788821e-07 4809 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_40 0327-0103 19.753 µM -8.70769796708874 3.60585502001759e-17 yes 3356 1.55054151521153e-18 4808 409036