SGTCid condition conc unit HST1|YOL068C.score HST1|YOL068C.strain.pval HST1|YOL068C.strain.significant HST1|YOL068C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1886 st057356 49.9 µM 7.95827349557136 1.12116898548203e-14 yes 1 8.72282008989324e-16 2 24207747 SGTC_2774 tamoxifen 10.92 µM 5.86124963282757 9.36377819895178e-09 yes 2 2.29698368164666e-09 2 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2483 5729050 27.16 µM 5.62295426532228 3.43253612515524e-08 yes 3 9.3859556246565e-09 8 2865180 SGTC_2518 prenyletin 46.28 µM 5.54594398056718 5.1667570717821e-08 yes 4 1.46186215082622e-08 1 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2330 7979373 200 µM 5.43186311105522 9.37741097058977e-08 yes 5 2.78843487613382e-08 16 1863007 SGTC_2937 9044753 11.33 µM 5.26205097037871 2.22876234124718e-07 yes 6 7.12286293018692e-08 13 6465530 YGL099W LSG1 SGTC_3032 9089427 49.47 µM 5.24531569557601 2.42388876763988e-07 yes 7 7.80074754238572e-08 3 17173707 SGTC_1676 st018489 23.4 µM 5.21223027531066 2.85925405210503e-07 yes 8 9.32918691294453e-08 11 3696235 SGTC_2572 astragaloside iv 100 µM 4.81958784458201 1.8851007327317e-06 yes 9 7.19275506995279e-07 10 45006101 An anti-inflammatory agent. SGTC_1744 st037937 38.9 µM 4.72576533850176 2.89904778547512e-06 yes 10 1.14625133750578e-06 9 1016152 SGTC_1707 st032323 6.317 µM 4.5818317823406 5.52625836013931e-06 yes 11 2.30460301839413e-06 43 3132057 YMR211W DML1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 4.53798744900197 6.70186893135893e-06 yes 12 2.83968198486745e-06 57 6708739 YPR165W RHO1 SGTC_3076 9116187 49.47 µM 4.45828403448869 9.47503910493278e-06 yes 13 4.13091898241162e-06 12 27241210 SGTC_85 0868-0259 160.055 µM 4.44239473958601 1.01454185226267e-05 yes 14 4.44815788195873e-06 6 83173 SGTC_1664 st014217 9.02 µM 4.13320405578349 3.67085583694598e-05 yes 15 1.78870422787842e-05 8 3982782 SGTC_3170 9103054 49.47 µM 4.07163305437698 4.69492010215538e-05 yes 16 2.33423414331992e-05 10 16432970 SGTC_1748 st037455 53.6035 µM 4.06113737855808 4.89440830582191e-05 yes 17 2.44171118069532e-05 29 580690 SGTC_55 0767-0285 6.563 µM 4.05325305037603 5.04949864520126e-05 yes 18 2.52551574621825e-05 40 3116166 SGTC_2237 6667747 47.222 µM 3.97914763512739 6.75199437071567e-05 yes 19 3.45813921093311e-05 15 729940 YDL015C TSC13 SGTC_143 4032-1194 15.74 µM 3.95444800453879 7.43063357246813e-05 yes 20 3.83557757400981e-05 67 1806963 SGTC_2161 5662504 8.5105 µM 3.92280546537451 8.39407497607204e-05 yes 21 4.37619096011023e-05 23 2859334 SGTC_2570 licareol 100 µM 3.89994887298499 9.16182614863829e-05 yes 22 4.81065016915294e-05 34 443158 SGTC_49 0717-0965 32.132 µM 3.88368099894428 9.74796269663723e-05 yes 23 5.14434383700333e-05 21 5889349 YGL099W LSG1 SGTC_2981 9013952 38.96 µM 3.87809496809176 9.95722916836808e-05 yes 24 5.26388113429799e-05 47 2996344 SGTC_810 3825-7150 143 µM 3.80561321266574 0.000130846145803129 yes 25 7.0726646153856e-05 12 22330411 YGL099W LSG1 SGTC_2919 7978188 46.38 µM 3.80328487635353 0.000131989219932236 yes 26 7.13949966866192e-05 25 2980291 SGTC_2913 7966556 36.57 µM 3.80182824780972 0.000132709090989803 yes 27 7.18161426835188e-05 14 2976516 SGTC_1519 esterone 74 µM 3.73797366519548 0.000168137481920625 yes 28 9.27546861223783e-05 21 698 A steroid. SGTC_1406 3909-7906 11.9 µM 3.70884631607621 0.000187080436207747 yes 29 0.000104102873245257 12 X1406 SGTC_1909 st060837 51.5 µM 3.70609324866179 0.000188970504726861 yes 30 0.0001052404159238 64 678937 SGTC_2238 6671620 73.2395 µM 3.68592619674875 0.000203369786911791 yes 31 0.000113936193084248 36 729941 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 3.65217382061174 0.000229783744467748 yes 32 0.00013001488665173 23 390807 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 3.5797239561643 0.000297648717354233 yes 33 0.000171978679068923 14 17037758 SGTC_1827 berberine 7.24 µM 3.5506807451544 0.000329762139248209 yes 34 0.000192118099989561 27 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1407 3909-7909 12.3 µM 3.53473768699856 0.000348732162518095 yes 35 0.000204090072435998 25 4411780 SGTC_1605 st000082 49.1 µM 3.53415235983115 0.000349447550829041 yes 36 0.000204542594738625 27 1114022 SGTC_1100 amiodarone 5.07 µM 3.52367178214692 0.000362490019303066 yes 37 0.000212805553783225 27 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2412 st077135 33.4 µM 3.51153868616991 0.000378153176527877 yes 38 0.000222760306921782 39 13258915 SGTC_862 0452-0056 10.2 µM 3.50003862566767 0.000393577111268117 yes 39 0.000232595373362157 43 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2338 7999974 200 µM 3.48434501972539 0.000415568744509837 yes 40 0.000246671541027277 36 315925 SGTC_2772 vinpocetine 57.06 µM 3.45982572454507 0.000452220352507839 yes 41 0.000270262548668869 40 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3339 9145883 14.936 µM 3.44587579611041 0.000474387730483648 yes 42 0.00028460595712693 24 2030670 SGTC_136 0097-0015 404.482 µM 3.40478338971368 0.000545670870508789 yes 43 0.000331082774710292 38 4861337 SGTC_2593 nobiletin 86.24 µM 3.4025636275438 0.00054979013266944 yes 44 0.000333784045436764 46 72344 An anti-infammatory. SGTC_1415 3966-0071 78.1 µM 3.39846212403644 0.000557477132147347 yes 45 0.000338829228082277 22 2893185 SGTC_2249 haloperidol 116.36 µM 3.39710265492263 0.000560046884660898 yes 46 0.000340517067467523 151 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 3.38526179309819 0.000582896786646679 yes 47 0.000355551996002684 67 368090 SGTC_2742 clothiapine 36.27 µM 3.35477050579535 0.000645761568235354 yes 48 0.000397154254788774 34 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_430 0958-0115 16.4 µM 3.2985715658842 0.000778293194954068 yes 49 0.000485890526278803 63 6833180 SGTC_1492 4158-0558 28.5 µM 3.2681558561713 0.000860057845070797 yes 50 0.000541253682054853 30 3967268 SGTC_1070 indatraline 8.81 µM 3.2582528386909 0.000888338709829283 yes 51 0.000560502398330125 51 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2707 st078556 66.6 µM 3.24197249197995 0.000936695524867988 yes 52 0.00059352739812838 26 17250899 SGTC_230 MPP+ 141.667 µM 3.18822448639116 0.00111402357586082 no 53 0.000715746774996468 47 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_706 4262-0057 46.9 µM 3.17241070494812 0.00117177182110782 no 54 0.000755895212042107 73 883298 SGTC_584 0986-0246 15.4 µM 3.14833779622883 0.00126495829027112 no 55 0.000821009118304326 42 53315 YDR232W HEM1 SGTC_2185 6113692 200 µM 3.14031943826618 0.00129747154955623 no 56 0.000843818524061318 39 874150 SGTC_364 0083-0097 67.7 µM 3.11358298119487 0.00141148310437422 no 57 0.000924152633227787 61 5207356 SGTC_2015 5119600 184 µM 3.10182303886513 0.0014644690416729 no 58 0.000961664475366312 65 2828786 SGTC_2927 9011802 47.9 µM 3.08332430674799 0.00155150007821673 no 59 0.00102350971223657 66 43912568 SGTC_171 k064-0041 9.68 µM 3.06770842381626 0.00162861095400328 no 60 0.00107853488496909 52 53325 SGTC_3081 9117243 49.47 µM 2.99129350672888 0.00205871358351568 no 61 0.00138899173033633 54 45595589 SGTC_785 1270-0111 65.3 µM 2.97980855197022 0.00213160159379809 no 62 0.00144214292917925 72 6741994 SGTC_3222 9128301 49.47 µM 2.97072566428445 0.00219089379044663 no 63 0.00148548521446163 66 4911358 SGTC_3118 9124250 49.47 µM 2.95997464735834 0.00226300495012317 no 64 0.00153832179967242 42 1504786 SGTC_604 1000-0114 314 µM 2.95862117557127 0.00227223397623902 no 65 0.00154509360866848 71 1572745 SGTC_2827 7993847 71.43 µM 2.94848011780283 0.00234247554433839 no 66 0.00159670340152968 64 2985692 SGTC_2576 guaiol 23.12 µM 2.9217740019839 0.00253695643428963 no 67 0.00174021992733405 90 227829 SGTC_978 1416-0512 87.4 µM 2.91793799633573 0.00256605933600374 no 68 0.0017617720316828 75 6814003 SGTC_1663 st014140 55.4 µM 2.88667299953084 0.00281474317807616 no 69 0.00194669319996303 70 4207120 SGTC_2605 digitonin 300 nM 2.87354170937781 0.00292552325025439 no 70 0.00202948739192037 96 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2415 st077333 57.7 µM 2.86149558728345 0.00303058881249498 no 71 0.0021082368665084 128 2766255 SGTC_3 0833-0587 95.581 µM 2.85663528491691 0.00307393378073765 no 72 0.00214078750143127 68 5382644 SGTC_2141 5621638 7.665 µM 2.83885848503482 0.00323726565309808 no 73 0.00226376155993225 71 2856238 SGTC_2186 6124449 200 µM 2.82923767399337 0.00332887965776907 no 74 0.0023329516866797 75 3834182 YLR033W RSC58 SGTC_198 3454-2873 16.191 µM 2.80581840887843 0.00356170608128893 no 75 0.00250944838061058 72 710957 SGTC_2246 7293507 91.5585 µM 2.80124804461845 0.00360881222375353 no 76 0.00254526873706702 92 887656 SGTC_609 0986-0026 86.3 µM 2.78526907991607 0.0037779315275001 no 77 0.00267416598562856 101 2848610 SGTC_10 0279-0212 42.575 µM 2.77529291456927 0.0038870878683584 no 78 0.00275760051328399 220 39851 YBR002C RER2 SGTC_975 1335-0046 28.5 µM 2.75821532461706 0.00408051985912026 no 79 0.00290589506475623 116 16486740 SGTC_2184 6075246 200 µM 2.75456196327473 0.00412300224695493 no 80 0.00293853801443919 86 2267320 SGTC_312 4092-0653 6.84 µM 2.75218901226454 0.00415080722115683 no 81 0.00295991712565851 167 1148278 SGTC_1967 st070177 51.4 µM 2.73648713309734 0.00433905927569891 no 82 0.00310495117080058 83 5729214 SGTC_425 3825-7017 13.1 µM 2.7272049455894 0.00445389983866331 no 83 0.00319366766242693 112 3397440 SGTC_1081 sertraline 6 µM 2.71672362179331 0.00458683348815774 no 84 0.00329658193010956 93 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_595 3909-8003 73.7 µM 2.71659097035125 0.00458853834874324 no 85 0.00329790330528121 69 699517 SGTC_2083 5306046 65.942 µM 2.70569571642181 0.00473051189720418 no 86 0.00340807349126808 116 539837 SGTC_229 benomyl 22.8748 µM 2.69884361426386 0.00482179450224837 no 87 0.003479043252793 83 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3242 9133940 49.47 µM 2.69875184473976 0.00482302762455947 no 88 0.00348000268572752 79 17248444 SGTC_1267 0828-0272 9.49 µM 2.6937266907501 0.00489098212359916 no 89 0.00353290390283486 82 745334 SGTC_344 k064-0035 6.43 µM 2.67472201935074 0.00515575973686197 no 90 0.00373956179692312 91 5088750 SGTC_3340 9146634 11.102 µM 2.67238492427584 0.00518918622372975 no 91 0.00376571006083758 85 4907387 SGTC_25 0118-0223 35.662 µM 2.66902854319796 0.00523752847406206 no 92 0.00380354926562888 85 5333628 SGTC_2628 lathosterol 100 µM 2.66268969403177 0.0053299214893392 no 93 0.00387594314683501 106 6710616 SGTC_2171 5739187 198.077 µM 2.63831623442609 0.00569882523891819 no 94 0.00416594221604975 79 2262761 SGTC_2078 5212016 200 µM 2.6280993186003 0.00586008840509229 no 95 0.00429317212005113 64 1899708 SGTC_893 0958-0369 48.9 µM 2.62681037727183 0.00588071787363788 no 96 0.00430946745506369 103 6819948 SGTC_1690 st023502 41.2 µM 2.5916395095991 0.00646905478523252 no 97 0.00477599020035371 75 24207482 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.58158292340754 0.00664658696551493 no 98 0.00491741805061825 110 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1940 st075990 51.1 µM 2.53990444136448 0.00742909125026272 no 99 0.00554413799990661 132 1084979 SGTC_2407 paclitaxel 400 µM 2.53972995655686 0.00743253093947619 no 100 0.0055469044458602 138 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1404 3909-7820 48.3 µM 2.52567085855359 0.00771433685129515 no 101 0.00577388069705536 84 23741373 SGTC_3276 9139060 49.47 µM 2.50455179478946 0.00815532981634434 no 102 0.00613033261251733 55 4870619 SGTC_816 0325-0417 81.3 µM 2.49262333855936 0.00841407595449587 no 103 0.00634016409416604 89 68101 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.46492084039682 0.00904295680923938 no 104 0.00685217621004645 124 5393153 SGTC_4 0960-0234 25.671 µM 2.45288524562198 0.00932876565999167 no 105 0.00708577699365567 99 6821112 SGTC_2382 9035899 200 µM 2.45099003093171 0.00937448416295395 no 106 0.00712319494343883 110 6462679 SGTC_1094 duloxetine 25.4 µM 2.45020967820976 0.00939336560066401 no 107 0.0071386523425455 133 60834 A selective serotonin reuptake inhibitor. SGTC_1808 st050063 61.5 µM 2.44608534689011 0.00949371154267216 no 108 0.00722084048716336 99 4011993 SGTC_3337 9144342 33.5465 µM 2.4448161261043 0.00952478000374307 no 109 0.00724630041058757 125 17682949 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.4414395364436 0.00960786661788313 no 110 0.00731441888979237 104 7104 SGTC_1732 st034308 51.822 µM 2.4182123453793 0.0101967683263207 no 111 0.00779848599734078 138 830119 SGTC_3300 9124615 50.48 µM 2.41786146992118 0.0102059006473629 no 112 0.00780600957357973 145 24824903 SGTC_1277 0873-0036 22 µM 2.41738169034117 0.010218399533864 no 113 0.00781630748655592 145 5965735 SGTC_1855 st056195 39.6 µM 2.40991290116294 0.0104146999043647 no 114 0.00797816464731757 116 4028379 SGTC_2598 perillyl alcohol 100 µM 2.40979473136973 0.0104178319652499 no 115 0.00798074902898058 157 10819 An apoptosis inducer. SGTC_1383 3049-0032 20.7 µM 2.38973255875213 0.0109616194928852 no 116 0.00843032275468077 130 712864 SGTC_2638 epoxomicin 18 µM 2.38937320668341 0.0109715807882062 no 117 0.00843857415237286 132 9915668 A protesome inhibitor. SGTC_1846 st056244 14.8 µM 2.38652744036957 0.0110507443929889 no 118 0.00850416901272452 160 5393182 SGTC_972 1319-0219 195 µM 2.3770613019435 0.0113176593774575 no 119 0.00872559381405115 139 23903702 SGTC_1667 st014849 34.6 µM 2.37124502499199 0.0114844240297059 no 120 0.00886413699009715 101 5348460 SGTC_3283 9109332 35.8195 µM 2.36907149090167 0.0115472893453942 no 121 0.00891640304041169 104 17027281 SGTC_301 4119-0100 24.5 µM 2.36453943136562 0.0116793323371477 no 122 0.00902625274597801 207 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_746 1095-0025 46.6 µM 2.36111785628304 0.0117798874450251 no 123 0.0091099696047987 129 6749286 SGTC_866 0495-0101 262 µM 2.34700093561718 0.0122027480809437 no 124 0.00946260362959008 130 635694 SGTC_221 trifluoperazine 10.304 µM 2.33556933373424 0.0125547510469444 no 125 0.00975684920890659 375 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1873 rapamycin 2 nM 2.33436809405713 0.0125922451615608 no 126 0.00978822798217732 215 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1674 st016616 23.6 µM 2.33186447466558 0.0126707018898638 no 127 0.00985391094339112 158 625830 SGTC_2437 5741531 144.16 µM 2.32359373848137 0.012932899104606 no 128 0.0100736391736642 158 2262990 SGTC_2077 5212015 200 µM 2.31337443258586 0.0132633385341914 no 129 0.0103510307728836 189 780900 SGTC_227 fluconazole 33.516 µM 2.30602036051841 0.0135056209961158 no 130 0.0105547473427656 223 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2014 4013930 200 µM 2.28787692797944 0.0141197616014408 no 131 0.011072344632922 185 64556 SGTC_2843 9000894 45.46 µM 2.28619254388725 0.0141779786872854 no 132 0.0111214983896331 71 2242070 SGTC_845 0330-0138 4.51 µM 2.27992583451771 0.0143963934851757 no 133 0.0113060437711003 146 9039800 SGTC_1092 toremifene 6.32 µM 2.27857106508044 0.0144439905253401 no 134 0.0113462877983478 165 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3255 9139072 49.47 µM 2.27797422028329 0.0144650023915752 no 135 0.0113640568010871 135 17646060 SGTC_2711 st079103 59.1 µM 2.27596395384807 0.0145359673143366 no 136 0.0114240835697304 112 54693780 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.27165139466686 0.0146892175668155 no 137 0.0115537870355843 154 688662 SGTC_1721 st082152 9.2685 µM 2.26817001408382 0.0148139432164255 no 138 0.0116594231678383 156 5296051 SGTC_156 3474-0145 5.642 µM 2.26623431868118 0.0148836855721074 no 139 0.0117185202294148 194 2265471 SGTC_968 1309-0633 340 µM 2.25080256854737 0.0154498505209901 no 140 0.0121990223971997 136 3761976 SGTC_2823 7987624 58.44 µM 2.24538053697584 0.0156531178021205 no 141 0.0123718568939921 205 2239440 SGTC_2788 5282734 71.43 µM 2.23834630799431 0.0159202409171044 no 142 0.0125992402373637 208 743706 SGTC_1709 st033179 39.1045 µM 2.23486354313124 0.0160539383569305 no 143 0.0127131543140911 163 573381 SGTC_1494 4358-1428 177 µM 2.22485319724311 0.0164435886998735 no 144 0.0130455474133634 161 1564571 SGTC_2566 crystal violet carbinol 226 nM 2.22270175167721 0.0165283822270569 no 145 0.0131179588572145 176 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2480 5767542 37.17 µM 2.21123188685332 0.0169867795428784 no 146 0.0135098916635136 132 2867358 SGTC_619 1652-1634 108 µM 2.20330611155142 0.0173098487544683 no 147 0.0137865902581853 153 5400454 SGTC_1476 4112-3294 3.34 µM 2.19689725663467 0.0175749096309062 no 148 0.0140138924157443 140 704369 SGTC_2399 5884133 200 µM 2.18284007477554 0.0181684489548219 no 149 0.014523794664762 237 722445 SGTC_3178 9107506 49.47 µM 2.18069878578519 0.0182603437922245 no 150 0.014602851459929 161 8897194 SGTC_2842 9000675 19.48 µM 2.15527056934161 0.0193822315754711 no 151 0.0155703337187777 179 2989072 SGTC_2523 spermine 47.74 µM 2.1552575122339 0.0193828223672776 no 152 0.0155708443092479 170 1103 A DNA binding polyamine. SGTC_1456 k015-0012 13 µM 2.14945881425304 0.0196467113076161 no 153 0.0157990237659336 209 2989616 SGTC_1010 4112-3296 15.2 µM 2.12896018053153 0.0206041533164785 no 154 0.0166287775039054 188 704384 SGTC_3319 9138450 16.7555 µM 2.12494554953152 0.0207962237547797 no 155 0.0167955783070732 180 2029690 SGTC_3033 9090887 49.47 µM 2.11494381785563 0.0212813357720329 no 156 0.017217367996848 210 19325384 SGTC_3251 9135047 49.47 µM 2.10997409286496 0.0215259188399169 no 157 0.0174302937215643 120 17682963 SGTC_2414 st077232 92.9 µM 2.10864913455413 0.0215915258529678 no 158 0.0174874391989718 201 729801 SGTC_115 0527-0192 112.043 µM 2.10854901193052 0.0215964904128953 no 159 0.0174917639826096 310 4233931 SGTC_2369 9071472 200 µM 2.10592419631084 0.0217269859024074 no 160 0.0176054687505198 197 17296037 SGTC_1186 1319-0216 26 µM 2.1058137498837 0.021732491436145 no 161 0.0176102669943572 201 4565136 SGTC_3195 9113082 49.47 µM 2.10481467075073 0.0217823471040057 no 162 0.0176537218081645 144 17018038 SGTC_389 tpck 16.7 µM 2.09568993019331 0.0222421729344189 no 163 0.0180548528588224 201 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_602 3130-1533 38.1 µM 2.09518110544874 0.0222680535924165 no 164 0.0180774481186634 215 720941 SGTC_416 estradiol valerate 100 µM 2.09474238912974 0.0222903886765621 no 165 0.0180969494383339 185 13791 A steroid. SGTC_2778 tioconazole 65.09 nM 2.09406115507361 0.0223251078161294 no 166 0.0181272664223073 262 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3345 9148410 3.559 µM 2.0820393451094 0.0229453454351173 no 167 0.0186694380200321 135 4903596 SGTC_183 3914-0051 30.55 µM 2.0780832391078 0.0231525998171465 no 168 0.0188508465635459 194 1596232 SGTC_361 000s-0510 1.45 µM 2.07166209881359 0.0234923480148909 no 169 0.0191484821415123 227 660 SGTC_2101 5377231 179.231 µM 2.04934713104072 0.0247058387318475 no 170 0.0202140915242748 165 2844213 SGTC_526 4469-0568 170 µM 2.04814905455378 0.0247724510205563 no 171 0.0202726982759545 223 2901964 SGTC_1974 st069448 26.9 µM 2.03826478575508 0.0253277792738057 no 172 0.0207617297702771 184 6323587 YNR016C ACC1 SGTC_1265 0819-1001 68.8 µM 2.03707709018553 0.0253952041492148 no 173 0.0208211586583201 201 3106768 SGTC_1625 st003711 30.1 µM 2.03220018806732 0.025673641575678 no 174 0.0210666969398085 214 24207034 YER133W GLC7 SGTC_2667 digitoxin 100 µM 2.02850972683035 0.0258860360849902 no 175 0.0212541257956197 107 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2068 5226020 147 µM 2.01083895998163 0.0269235056988568 no 176 0.0221712347329242 264 1810509 SGTC_1222 0366-0074 1.18 µM 2.00635246372371 0.0271923689608294 no 177 0.0224093281195754 202 286520 SGTC_471 1-acyl-paf 4 µM 1.99938622712756 0.0276142730553878 no 178 0.0227832904843468 217 16759367 SGTC_3332 9141069 11.198 µM 1.99443459801115 0.0279174702205925 no 179 0.0230522903383684 185 17332883 SGTC_994 3910-0338 138 µM 1.98348405108407 0.0285978473313037 no 180 0.0236566934146727 260 3479481 SGTC_1436 4092-1007 8.32 µM 1.98022783427093 0.0288028023313518 no 181 0.0238389667832272 208 2881121 SGTC_2404 5161160 200 µM 1.97760015105089 0.0289690847786273 no 182 0.0239869161120898 254 2831543 SGTC_2938 9059746 27.26 µM 1.97747110098958 0.0289772717073914 no 183 0.0239942019925667 231 6471769 SGTC_2354 9060492 162 µM 1.975313152148 0.0291144570084507 no 184 0.024116310804806 244 6471895 SGTC_3027 9089541 49.47 µM 1.96389150670898 0.0298495700021687 no 185 0.0247713375100991 240 9943819 SGTC_1917 st066507 28.5 µM 1.95507453562371 0.0304275158867646 no 186 0.0252871366804633 291 3156428 SGTC_407 eburnamonine 100 µM 1.95294487448777 0.0305684951349659 no 187 0.0254130637832951 201 3195 SGTC_1315 1237-0019 3.69 µM 1.95147595914196 0.030666049282883 no 188 0.0255002266597201 197 825140 SGTC_634 1611-4317 11.2 µM 1.94045786637434 0.0314060352536508 no 189 0.0261620349669122 256 2843522 SGTC_288 1315-0019 35.1 µM 1.93812624225171 0.0315645073142979 no 190 0.0263039112750138 247 6811474 SGTC_348 k064-0012 10.7 µM 1.93293796795171 0.031919507914455 no 191 0.026621919961407 203 5066323 SGTC_1475 4092-1048 11.7 µM 1.92283897541504 0.032619975152874 no 192 0.0272501377987786 278 2881759 SGTC_2771 fluoxetine 41.05 µM 1.92102461198538 0.0327471532195544 no 193 0.0273643023551114 216 3386 A selective serotonin reuptake inhibitor. SGTC_3343 9148379 18.9835 µM 1.91948820944895 0.0328551669916781 no 194 0.0274612885198752 214 1955036 SGTC_2115 tiliquinol 12.7705 µM 1.91415077711902 0.0332326892828513 no 195 0.0278004465401873 198 71208 A bioactive hydroxyquinoline. SGTC_1213 1315-0166 115 µM 1.91279851141162 0.0333289017024196 no 196 0.0278869259050418 219 768401 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.91136696170438 0.033431004937849 no 197 0.0279787196672661 236 165521 SGTC_1923 st058458 19.1 µM 1.90833110807136 0.0336483851372516 no 198 0.0281742173922301 296 3534982 SGTC_679 0422-0091 41.4 µM 1.8978772083795 0.0344058457970152 no 199 0.0288561296877224 302 627384 YHR062C RPP1 SGTC_24 0417-1663 219 µM 1.89483644610878 0.0346287830851983 no 200 0.0290570365379206 234 4329390 SGTC_1505 k297-0037 20.6 µM 1.8933283577965 0.0347397898195562 no 201 0.0291571081197976 256 4089396 SGTC_3034 9090421 49.47 µM 1.8904206253582 0.034954645800917 no 202 0.0293508635423203 198 17173761 SGTC_3316 9136639 10.545 µM 1.88764004114429 0.0351611256523196 no 203 0.029537145388295 228 4903665 SGTC_2776 terbinafine 19.92 µM 1.88405650436749 0.0354287057255115 no 204 0.0297786664059503 273 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_196 k015-0023 18.111 µM 1.88026638343529 0.0357135259126673 no 205 0.0300358911887731 263 5211998 SGTC_1435 4092-0789 56.7 µM 1.87834360218217 0.035858735070608 no 206 0.0301670876908294 233 2248285 SGTC_338 4055-0136 114 µM 1.86615644190009 0.0367904012891718 no 207 0.0310097405990476 271 2900563 SGTC_942 3253-1115 227 µM 1.8642865710926 0.036935082708734 no 208 0.0311407358164776 271 46497897 SGTC_646 4092-0839 27.3 µM 1.86410724461297 0.0369489825214387 no 209 0.0311533226897553 255 877796 SGTC_490 phenamil 164 µM 1.84442198131838 0.0385010089573752 no 210 0.03256083314203 154 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_458 nppb 133 µM 1.84094378106774 0.0387806841845979 no 211 0.0328148988289781 227 4549 A chloride channel blocker. SGTC_1327 1436-0082 2.18 µM 1.82437166401159 0.040136024880621 no 212 0.0340479514247747 270 15992205 SGTC_1231 0242-0792 125 µM 1.82348882505248 0.0402092936186355 no 213 0.0341146940347121 265 3707635 SGTC_1444 4112-3581 28 µM 1.82334681890038 0.0402210891573895 no 214 0.0341254397336241 255 2877249 SGTC_2180 6301957 200 µM 1.82234418080675 0.0403044518648698 no 215 0.0342013892305199 214 845462 SGTC_100 0086-0128 49.5915 µM 1.82023087371587 0.0404806189248709 no 216 0.0343619266583542 354 93297 SGTC_2122 5258151 111.688 µM 1.80231705859514 0.0419991670565188 no 217 0.0357477680814752 294 2173356 SGTC_145 3737-0113 38.366 µM 1.79487130465483 0.0426437599561764 no 218 0.0363371033995667 395 6849351 SGTC_2716 st080858 38.6235 µM 1.79217806209323 0.0428788797048592 no 219 0.0365522238060937 243 5296050 SGTC_2724 maprotiline 69.64 µM 1.79062545362653 0.0430148975862099 no 220 0.0366767098032385 253 4011 A tricyclic antidepressant. SGTC_683 panaxydol 45 µM 1.78930444920329 0.0431308998367351 no 221 0.03678289896157 300 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3349 9149703 23.001 µM 1.78521467773586 0.0434916406419594 no 222 0.0371132510412999 264 4910494 SGTC_1637 st007924 17.4 µM 1.78285522073633 0.0437008633491883 no 223 0.037304937001632 282 683336 SGTC_2536 dehydroabietamide 32.04 µM 1.7802033235428 0.0439369864632199 no 224 0.0375213458456445 317 3983547 SGTC_1023 4482-3888 16 µM 1.77976323738784 0.0439762707980169 no 225 0.0375573581893136 278 3303168 SGTC_1547 harmine 94.2 µM 1.7764184393534 0.0442757711037329 no 226 0.0378319870399617 368 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3162 9099653 49.47 µM 1.7715817333603 0.0447117652252714 no 227 0.0382320070594213 227 25237511 SGTC_912 3474-0017 2.18 µM 1.76830453067218 0.0450091415845578 no 228 0.0385050034501742 311 3360550 SGTC_512 prima-1 270 µM 1.75487289703812 0.0462446108763123 no 229 0.0396405255235952 300 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2744 captopril 92.04 µM 1.75255783201807 0.0464602813356719 no 230 0.0398389673900326 212 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_112 phenothiazine 287.218 µM 1.75234280751904 0.0464803538340261 no 231 0.0398574396912712 279 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2038 4100038 30.985 µM 1.7501045148257 0.0466897116555319 no 232 0.0400501404294772 328 3596803 SGTC_2852 9023854 51.95 µM 1.74671895802968 0.0470078153573776 no 233 0.0403430501118345 310 19798528 SGTC_3089 9117425 49.47 µM 1.74483581006094 0.0471855049161221 no 234 0.0405067267133487 309 9401657 SGTC_3132 9126706 49.47 µM 1.7374467542054 0.0478879263017538 no 235 0.0411541723636649 294 850858 SGTC_2974 9094440 9.66 µM 1.73064262307182 0.0485421231652774 no 236 0.041757762311684 368 25236134 SGTC_3280 9140961 49.47 µM 1.7264874373037 0.0489451335109799 no 237 0.0421298787386212 263 4901226 SGTC_2011 4012611 177 µM 1.72397575685062 0.0491900342007696 no 238 0.0423561098889988 325 2049887 SGTC_330 1488-0319 80.1 µM 1.72188609211091 0.0493945312931293 no 239 0.0425450774301102 294 6846614 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.72001212855779 0.0495784963047682 no 240 0.0427151184748491 311 521171 SGTC_1895 st058434 18.3 µM 1.71897215986385 0.0496808246043189 no 241 0.0428097206839378 315 5393175 SGTC_1716 st033144 30.6155 µM 1.7163048993922 0.0499440416293417 no 242 0.0430531260361685 318 674617 SGTC_2692 st077426 47.7 µM 1.70967798352386 0.0506028303799348 no 243 0.0436627180866701 331 25238571 SGTC_318 1488-0629 67.2 µM 1.70893113493929 0.0506775073881414 no 244 0.0437318532128455 285 3662576 SGTC_3101 9120531 49.47 µM 1.70709085454631 0.050861890693248 no 245 0.0439025833534353 338 24824904 SGTC_2021 4019055 173 µM 1.70681083612072 0.0508899933527441 no 246 0.0439286088393544 512 44827708 YER133W GLC7 SGTC_2595 hexamethylquercetagetin 100 µM 1.70565108624443 0.0510065175396402 no 247 0.0440365308847293 298 386331 SGTC_2648 atorvastatin 78.68 µM 1.70365660375899 0.0512074068275271 no 248 0.0442226299808953 279 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_738 1315-0003 72.4 µM 1.70071719283986 0.0515046186637115 no 249 0.04449805254199 336 6251474 SGTC_1971 st069429 63.5 µM 1.69965250048753 0.0516126104245069 no 250 0.0445981544217573 277 1246522 YGL099W LSG1 SGTC_3326 9140064 16.379 µM 1.69923853161074 0.0516546478691321 no 251 0.0446371245240178 306 1868434 SGTC_2442 5158906 48.48 µM 1.69774604269375 0.0518064321867157 no 252 0.0447778518326396 336 1893835 SGTC_264 promethazine 12.5 mM 1.69554727577895 0.0520306896738511 no 253 0.0449858249631286 455 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2693 st077581 40.7 µM 1.69033590932273 0.0525652897685023 no 254 0.0454818544312729 428 25238761 SGTC_556 4058-0063 51.5 µM 1.68079293315199 0.0535555341706591 no 255 0.0464015708915923 346 6615692 SGTC_692 k241-0027 77.8 µM 1.67969032270842 0.0536708947681399 no 256 0.0465087918109552 317 3600480 SGTC_2200 6600604 21.907 µM 1.67757496760625 0.0538927647127839 no 257 0.0467150515000251 372 2904777 SGTC_1723 st034307 2.5525 µM 1.67011168108913 0.0546813604154298 no 258 0.0474486347288682 337 867466 SGTC_610 4215-0184 155 µM 1.66818537077894 0.0548863749806478 no 259 0.0476394670300156 350 5605015 SGTC_2044 5102272 200 µM 1.66019701307333 0.055743055380296 no 260 0.0484374126773836 289 592666 SGTC_1041 0206-0046 107 µM 1.65433373708057 0.0563785277146436 no 261 0.0490298608971136 337 50494 SGTC_934 2950-0684 338 µM 1.65157186384009 0.0566798362030307 no 262 0.0493109298367116 364 1121253 SGTC_378 3970-0959 8.33 µM 1.65099442275204 0.0567429925940645 no 263 0.0493698568671525 338 6615653 SGTC_1105 epirubicin 18.1 µM 1.64804924053961 0.0570659784284845 no 264 0.0496712835820224 350 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2625 euphol 100 µM 1.64589512695437 0.0573031261417603 no 265 0.0498926762049132 397 6708538 A triterpene alcohol. SGTC_3307 9126885 69.2785 µM 1.64541206971798 0.057356412518717 no 266 0.0499424310948532 386 24824909 SGTC_922 1866-0035 480 µM 1.63898554873451 0.058069042043741 no 267 0.0506081346991696 437 3156169 SGTC_2832 7992762 51.95 µM 1.63815115651343 0.058162074961007 no 268 0.0506950828499921 316 2985177 SGTC_1515 3460-0031 42.1 µM 1.6321791556958 0.0588313627040372 no 269 0.0513208752619147 292 2876596 SGTC_673 1082-0474 110 µM 1.62657480583033 0.0594649305133521 no 270 0.0519137168913945 445 3098046 SGTC_2131 toluylene red 5.2905 µM 1.62564168450543 0.0595709366838985 no 271 0.0520129510944512 377 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1379 2144-0755 36.5 µM 1.62384659169409 0.0597752825755375 no 272 0.0522042767415502 391 5392327 SGTC_850 0388-0143 75.9 µM 1.62221759489847 0.0599611956996321 no 273 0.0523783828097879 341 67273 SGTC_1765 st044815 90.4 µM 1.62018496343183 0.0601938092937551 no 274 0.0525962752341772 372 645695 SGTC_96 0929-0093 37.281 µM 1.61285354753163 0.0610386870826977 no 275 0.053388164660757 344 6991579 SGTC_1797 st048695 56.8 µM 1.61256437840559 0.0610722001987232 no 276 0.05341959136864 381 592262 YIL048W NEO1 SGTC_708 3448-5400 146 µM 1.61056519474096 0.0613042881915874 no 277 0.0536372625127632 396 3462195 SGTC_1084 voriconazole 435 nM 1.61029173373971 0.0613360881615579 no 278 0.0536670914977937 366 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1749 st037932 54.2 µM 1.60515177583629 0.0619361992315658 no 279 0.0542302036198075 365 594497 SGTC_2108 5365811 200 µM 1.60382489830739 0.0620918593277423 no 280 0.0543763273761372 377 780283 SGTC_402 epigallocatechin gallate 10 µM 1.60274870730475 0.0622183346456044 no 281 0.054495072632212 388 65064 An antioxidant. SGTC_1986 st071812 45 µM 1.60016188474077 0.0625231632830564 no 282 0.0547813376343597 317 11838594 SGTC_3287 9117173 37.0625 µM 1.59595199614839 0.0630217401588248 no 283 0.0552497556464401 279 2789709 SGTC_113 0099-0221 2.5 µM 1.59584507274035 0.0630344433002535 no 284 0.0552616936652681 342 89219 SGTC_2935 9038016 29.96 µM 1.59282584483927 0.0633939695660784 no 285 0.0555996327615237 400 6463195 SGTC_1594 piperine 70.1 µM 1.59233376649238 0.0634527166804008 no 286 0.0556548648561681 392 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2958 9077254 16.72 µM 1.59159068682625 0.063541510055146 no 287 0.0557383520203576 347 16457351 SGTC_1366 1683-0113 21.9 µM 1.58603825580098 0.0642080546445829 no 288 0.056365315846973 352 708623 SGTC_3185 9108267 49.47 µM 1.58592705452484 0.0642214591615357 no 289 0.0563779289075919 393 4910486 SGTC_140 0062-0056 502.533 µM 1.5852721487538 0.0643004474900368 no 290 0.0564522570620778 426 3758964 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.58515144601034 0.0643150137108328 no 291 0.05646596457545 404 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1606 st000094 49.2 µM 1.58409145102765 0.0644430424343894 no 292 0.0565864547756839 378 1242210 SGTC_1764 st044502 93.5 µM 1.58269182939224 0.0646123953162256 no 293 0.056745860753132 388 8407 SGTC_1144 3486-0183 12.5 µM 1.5825310161762 0.0646318756820856 no 294 0.0567641987557666 404 6744069 SGTC_744 1594-0068 283 µM 1.58122159356746 0.0647906645184409 no 295 0.056913689849074 439 668392 SGTC_1490 4089-0339 670 nM 1.57992235861512 0.0649485171609369 no 296 0.0570623240943376 302 742542 SGTC_3126 9127922 49.47 µM 1.57875231758041 0.0650909285172891 no 297 0.0571964397376893 394 45595682 SGTC_1215 3852-0577 11.2 µM 1.57839754003736 0.0651341580555904 no 298 0.0572371550003223 409 2884876 SGTC_2482 5981709 142.65 µM 1.57477434055567 0.0655769203975228 no 299 0.0576542706059194 420 877755 SGTC_1649 st011737 51.3 µM 1.5744202549601 0.0656203152572013 no 300 0.0576951620900234 373 1761035 SGTC_405 ebelactone b 50 µM 1.56807496665482 0.0664017403126163 no 301 0.0584318189702256 402 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_888 0916-0002 6.97 µM 1.56578864884407 0.0666850604608705 no 302 0.0586990522538072 368 2802138 YIL048W NEO1 SGTC_1434 4073-0095 163 µM 1.55831385592809 0.0676178674182558 no 303 0.0595794329787838 378 24133745 SGTC_2879 9041815 71.43 µM 1.55677131547595 0.0678116156931532 no 304 0.0597623949155718 256 4942971 SGTC_2629 bisabolol 100 µM 1.55462408032482 0.0680820291602292 no 305 0.0600178126536487 419 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2378 9074213 121.43 µM 1.55379474981827 0.0681866940153073 no 306 0.0601166916467975 422 657714 SGTC_1249 0481-0015 10.2 µM 1.55162451402453 0.0684611742614027 no 307 0.0603760470267304 344 4227577 SGTC_2869 9037858 32.47 µM 1.54547913380627 0.0692430351222501 no 308 0.0611152061243441 328 27187042 SGTC_2182 6325192 200 µM 1.5449226990116 0.0693141671507246 no 309 0.06118248111395 358 736248 SGTC_2585 alliin 100 µM 1.54232369743489 0.069647157082148 no 310 0.0614974765683456 435 87310 A garlic compound which reacts with lipids. SGTC_148 3253-0744 288.01 µM 1.54194109767798 0.0696962804448007 no 311 0.0615439539013307 376 6893655 SGTC_1206 3978-0017 132 µM 1.54193172015078 0.069697484794128 no 312 0.0615450934059524 381 3873677 SGTC_291 SEC14.278 35.5 µM 1.53655943432623 0.0703900809224718 no 313 0.0622006164139387 410 1068044 SGTC_884 0851-0618 334 µM 1.53635336363544 0.0704167525997551 no 314 0.0622258690766817 430 9642473 SGTC_2 0422-0095 29 µM 1.53426719662791 0.0706872023281487 no 315 0.0624819661533297 295 6790840 SGTC_722 3534-0461 190 µM 1.53376175775351 0.0707528471612665 no 316 0.0625441371365491 418 658262 SGTC_2699 st077704 54.6 µM 1.53362775596824 0.0707702587506765 no 317 0.0625606279717944 405 645852 SGTC_781 4335-2806 94.4 µM 1.53120911477834 0.071085092394261 no 318 0.0628588594133488 453 845254 SGTC_2998 9066762 71.4286 µM 1.53000965589583 0.0712416239476145 no 319 0.0630071694322025 469 4945196 SGTC_424 splitomicin 100 mM 1.5208089018419 0.0724511524021154 no 320 0.0641538999393687 397 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.51955759505179 0.0726168569321153 no 321 0.0643111011709099 455 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2676 harmalol 100 µM 1.5189821898269 0.0726931524310237 no 322 0.0643834895309351 416 5459187 A monoamine oxidase inhibitor SGTC_1460 k062-0059 9.15 µM 1.51879131810266 0.0727184745028836 no 323 0.0644075159635837 388 1373085 SGTC_3224 9130643 49.47 µM 1.51682594699444 0.0729796042111523 no 324 0.0646553170912074 413 17644395 SGTC_1019 4262-0212 3.4 µM 1.51172900843386 0.0736601546501209 no 325 0.0653014079117096 502 4677213 SGTC_2756 carbadox 75.1 µM 1.51119814123281 0.0737313148452812 no 326 0.0653689879272088 457 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_569 4130-2812 160 µM 1.51033535004151 0.0738470799419362 no 327 0.0654789379728092 306 743552 SGTC_2143 5623677 140.463 µM 1.50972398946141 0.0739291933616786 no 328 0.0655569336666145 344 5375313 SGTC_2424 5537928 59.2 µM 1.50558592080018 0.0744868234660533 no 329 0.0660867524840641 468 5382802 SGTC_1126 isoteolin 1.0172 µM 1.50486681166525 0.074584054448728 no 330 0.0661791612109098 428 133323 SGTC_2219 9098279 200 µM 1.49908329012467 0.0753695720722297 no 331 0.0669260129793789 412 902349 SGTC_403 arphamenine a 50 µM 1.49873609616213 0.0754169278181214 no 332 0.0669710542832506 444 5487158 An arginine aminopeptidase inhibitor. SGTC_159 3970-0959 50 µM 1.49679883805209 0.0756815777693332 no 333 0.0672228043698165 646 6615653 SGTC_1405 3909-7894 12 µM 1.49484662573736 0.0759489857220085 no 334 0.0674772373264342 415 7104060 SGTC_2196 6573537 42.6665 µM 1.49460288519654 0.0759824229980357 no 335 0.0675090563623631 368 2903087 SGTC_924 2046-0044 21.3 µM 1.49226092837596 0.076304273217002 no 336 0.0678153776236977 423 3623589 SGTC_1151 3909-8316 15.3 µM 1.49202684050604 0.0763365003673398 no 337 0.0678460545670334 438 800431 SGTC_1852 st056254 31.4 µM 1.490783140488 0.0765078957160338 no 338 0.0680092197734821 409 442583 SGTC_1461 k072-0203 53.8 µM 1.48946336618359 0.0766900949060438 no 339 0.0681826965816167 400 5418714 SGTC_2159 5658611 73.75 µM 1.48880749366862 0.0767807629117361 no 340 0.0682690342303767 385 793844 SGTC_2896 9052656 71.43 µM 1.48768417002768 0.0769362408006003 no 341 0.0684171021091617 575 6469436 SGTC_377 3970-0964 33.1 µM 1.48702510948211 0.0770275719148554 no 342 0.0685040896571401 532 16481235 SGTC_2752 diclazuril 33.15 µM 1.48187222134082 0.0777444902631675 no 343 0.0691871488479962 610 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1999 st074831 12.5 µM 1.47744149939597 0.0783649742341018 no 344 0.0697786644407543 456 17112523 SGTC_2059 5238311 157 µM 1.47458586748047 0.0787668659646032 no 345 0.0701619583586182 414 703021 SGTC_861 0443-0273 110 µM 1.47253263756578 0.0790567941827709 no 346 0.0704385501211344 419 6149169 SGTC_202 3594-0513 34.79 µM 1.4687839664 0.0795882124938025 no 347 0.0709456971338355 387 708429 SGTC_2993 9054257 71.4286 µM 1.46791921001245 0.0797111846954739 no 348 0.0710630847178579 470 6470217 YGL055W OLE1 SGTC_3246 9135460 32.98 µM 1.46525231801497 0.0800913337713931 no 349 0.0714260451891155 353 41446951 SGTC_2694 st077685 81.9 µM 1.46364775500109 0.080320713822736 no 350 0.071645108629035 442 2838096 SGTC_1932 st074806 40.9 µM 1.46339772043063 0.0803565021365318 no 351 0.0716792910415554 478 17251235 SGTC_1802 st050112 57.9 µM 1.46160327597088 0.0806137008118826 no 352 0.0719249780803125 447 4662563 SGTC_1591 genipin 88.4 µM 1.45322133139328 0.0818233300738135 no 353 0.0730811556705678 391 442424 A DNA cross-linking agent. SGTC_2859 9028643 45.46 µM 1.44709313170757 0.0827163343643042 no 354 0.0739354207057158 401 17151580 SGTC_1145 3546-0597 10.2 µM 1.44645150760778 0.0828102546588112 no 355 0.0740253019266208 474 875334 SGTC_2265 7929201 200 µM 1.44343213749787 0.0832533045057669 no 356 0.0744493882216273 463 1265108 SGTC_341 1486-1430 230 µM 1.44294066527527 0.0833255894391146 no 357 0.0745185932417794 441 2054753 YPL210C SRP72 SGTC_925 2064-1272 59.6 µM 1.43923222302946 0.0838725429070064 no 358 0.0750423692887143 438 6815817 SGTC_2347 9049783 174.81 µM 1.43888116399295 0.0839244595418418 no 359 0.0750920975691053 495 6467988 YPL169C MEX67 SGTC_2022 5136654 200 µM 1.43782456734629 0.0840808607670344 no 360 0.0752419184337076 457 1713771 SGTC_3249 9135183 49.47 µM 1.43444767806718 0.0845821873013087 no 361 0.0757222750233801 476 4902779 SGTC_2445 5742597 35.57 µM 1.43433509512944 0.0845989396874749 no 362 0.0757383298947666 453 1774255 SGTC_1794 st048918 76.9 µM 1.42186354882552 0.0864701573227374 no 363 0.0775329334204905 366 672303 SGTC_660 4031-1742 102 µM 1.42122674512797 0.0865665264617964 no 364 0.0776254259262621 521 6738706 SGTC_2473 5854593 8.94 µM 1.42110057926914 0.0865856289904158 no 365 0.0776437608157004 422 2872951 SGTC_2307 7538926 6.34 µM 1.42063088962708 0.0866567714907193 no 366 0.0777120467563945 496 96582 SGTC_1303 1160-0052 261 µM 1.41920602921327 0.0868728581733292 no 367 0.0779194793568314 459 3562476 SGTC_2102 5377816 72.7585 µM 1.41851326976678 0.0869780636851888 no 368 0.078020483643122 487 1379702 SGTC_2279 7948423 32.93 µM 1.41816738752301 0.0870306264990801 no 369 0.0780709504186338 415 1247112 SGTC_1994 st072947 40.9 µM 1.41559600466418 0.0874221368305338 no 370 0.0784469108809916 468 5286565 YDL195W SEC31 SGTC_2986 9022445 71.43 µM 1.41557439835737 0.0874254320962803 no 371 0.0784500757320302 470 6459286 SGTC_1450 4112-4260 37.6 µM 1.4134485671797 0.0877501047478245 no 372 0.0787619370000457 476 1633175 SGTC_2928 9011484 9.79 µM 1.41287257884391 0.0878382286201422 no 373 0.0788465965135109 432 2994751 SGTC_1552 6-methylflavone 10.6 µM 1.41237766936529 0.0879140004680506 no 374 0.078919394003811 414 689013 SGTC_3157 9099274 49.47 µM 1.40758824521531 0.0886497929811857 no 375 0.0796265150803571 437 17217662 SGTC_945 3381-0768 11.3 µM 1.4044543578078 0.0891337241643191 no 376 0.0800917969589965 507 1126236 YIL048W NEO1 SGTC_1578 josamycin 24.2 µM 1.40313369909908 0.0893382464974528 no 377 0.0802884869054529 426 5282165 A P450 substrate. SGTC_558 k064-0027 21.3 µM 1.40269370079261 0.0894064638168165 no 378 0.0803540982704495 475 5088526 SGTC_320 4092-0846 5.34 µM 1.40173096719087 0.0895558611207039 no 379 0.0804977998132275 472 1359356 SGTC_1491 4138-0063 26.5 µM 1.40054857757006 0.0897395986283619 no 380 0.0806745536415559 429 23883227 SGTC_1410 3909-8106 77.9 µM 1.39870539929468 0.0900265781292882 no 381 0.0809506722276599 456 1039210 SGTC_3333 9141820 12.094 µM 1.39834706702295 0.0900824488959322 no 382 0.0810044351658619 432 1939433 SGTC_1048 3161-0300 24.5 µM 1.39750467704547 0.0902138948574329 no 383 0.0811309305965315 518 2165101 SGTC_1910 st062352 60.4 µM 1.39549895724989 0.0905274393755398 no 384 0.0814327145088155 485 2245730 SGTC_3329 9141233 27.5565 µM 1.39548975172347 0.0905288802938601 no 385 0.0814341015366679 442 4909101 YNL103W MET4 SGTC_1062 mesoridazine 14.2 µM 1.39499362320878 0.0906065632543582 no 386 0.0815088812614102 502 4078 A neuroleptic. SGTC_1342 1486-1464 234 µM 1.39435380986349 0.0907068171788974 no 387 0.0816053945380802 495 3253938 SGTC_2221 6807166 181.081 µM 1.39234907715287 0.0910214767593642 no 388 0.0819083583971271 386 674925 SGTC_685 1278-0033 54.9 µM 1.39056595866835 0.0913020318442697 no 389 0.0821785425155641 516 3590572 SGTC_1685 st024049 53.0905 µM 1.38852911878084 0.0916232912068005 no 390 0.0824879921223652 436 1941139 SGTC_1324 1418-0026 34.4 µM 1.38595284377849 0.0920308313981588 no 391 0.0828806516087683 503 1372513 SGTC_675 1309-0189 238 µM 1.38573105976126 0.0920659779964271 no 392 0.0829145201475503 478 4246530 SGTC_997 3996-0078 137 µM 1.38417205370555 0.0923133175989679 no 393 0.0831528891505903 510 735687 SGTC_1152 3909-8331 15.9 µM 1.38213934305913 0.0926365496090686 no 394 0.0834644601551117 464 16001939 SGTC_485 niflumic acid 177 µM 1.381277271903 0.092773884596138 no 395 0.0835968618422867 462 4488 A COX2 inhibitor. SGTC_473 2-arachidonoylglycerol 10 µM 1.37776941368839 0.0933342680532132 no 396 0.0841372461341784 493 5282280 An endocannabinoid. SGTC_1220 1838-0075 193 µM 1.37639884842016 0.0935538951333537 no 397 0.0843490921612122 506 5529645 SGTC_2647 atorvastatin 60.16 µM 1.36808912040252 0.0948936696463029 no 398 0.0856420908812683 478 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2067 5224629 34.075 µM 1.36456298816806 0.095466439097681 no 399 0.0861952221436435 500 2835000 SGTC_829 1635-0120 117 µM 1.36430174353634 0.0955089755580109 no 400 0.0862363086963577 536 285054 SGTC_565 1418-0001 44.5 µM 1.36297249110884 0.0957256236039762 no 401 0.0864455902338472 542 2862145 SGTC_1121 fusaric acid 630.51 nM 1.36267558499006 0.0957740641710152 no 402 0.0864923878741619 511 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2063 5246145 200 µM 1.36195780533109 0.0958912452170375 no 403 0.0866056008443127 526 711240 SGTC_2130 NSC 7 2.4545 µM 1.35226175448279 0.0974845188671746 no 404 0.0881457972743902 544 21448 SGTC_851 0394-0702 453 µM 1.34946847565869 0.0979470983132587 no 405 0.0885932696681827 554 762646 SGTC_665 3914-0008 307 µM 1.34818923720679 0.0981594821470875 no 406 0.0887987626951013 498 1069549 SGTC_3071 9117417 49.47 µM 1.34698134645467 0.0983603300659811 no 407 0.0889931202238116 414 45595590 YGL055W OLE1 SGTC_2323 6148992 148.28 µM 1.34598418197101 0.0985263650992099 no 408 0.0891538089825194 455 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1068 loratadine 26.9 µM 1.33564391752386 0.100260202305869 no 409 0.0908328441222335 497 3957 A H1 histamine antagonist. SGTC_748 act1.228 77.9 µM 1.33257322517277 0.100779354126073 no 410 0.0913359483041672 583 4421505 YNR035C ARC35 SGTC_2137 5261020 140 µM 1.32968484092708 0.101269470376714 no 411 0.091811065748181 503 763655 SGTC_1493 4348-0038 111 µM 1.32254687293548 0.10248812257474 no 412 0.0929930558975088 576 800424 SGTC_525 k781-2675 26.7 µM 1.32161304710774 0.102648338317784 no 413 0.0931485182699582 568 3651118 YDL195W SEC31 SGTC_1 0258-0098 57.368 µM 1.31978235585886 0.102962956657227 no 414 0.0934538470817984 463 6790032 YDR047W HEM12 SGTC_77 0828-0286 12.516 µM 1.31933429144824 0.103040066562577 no 415 0.0935286892434047 557 745345 SGTC_1675 st018485 24.5 µM 1.3189677556163 0.103103176944803 no 416 0.0935899462382197 536 3323024 SGTC_2541 muurolladie-3-one 83.07 µM 1.31828582859219 0.103220666283418 no 417 0.0937039915478151 526 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_605 1315-0399 119 µM 1.31315862007743 0.104107148468776 no 418 0.0945647521527486 585 24020461 SGTC_1403 3909-7815 62.9 µM 1.30850101456564 0.104917210295601 no 419 0.0953517153369731 479 6615483 SGTC_2191 5911152 200 µM 1.3078022140107 0.1050391399635 no 420 0.095470201540834 519 2875902 SGTC_1522 st012842 45.6 µM 1.30765504732657 0.105064831296476 no 421 0.0954951684229609 500 3491067 YOR116C RPO31 SGTC_756 0508-1999 28.3 µM 1.30232510710296 0.105998362340655 no 422 0.0964026361927443 524 6753853 SGTC_1049 3226-0134 66 µM 1.29696091658716 0.106943929032256 no 423 0.0973223173806367 578 5702385 SGTC_1964 st076914 61 µM 1.29686959696866 0.106960078803336 no 424 0.0973380295026848 519 24208661 SGTC_372 0155-0182 15.9 µM 1.29618309797859 0.107081541698728 no 425 0.0974562056103113 600 771486 SGTC_2302 7771753 200 µM 1.2921662535504 0.107794239908395 no 426 0.0981497878228959 589 2203047 SGTC_2128 5255449 168.493 µM 1.290470237731 0.108096183222795 no 427 0.0984437194809801 585 736008 SGTC_2847 9005661 71.43 µM 1.28862531217432 0.108425327989888 no 428 0.098764189598789 408 2991449 SGTC_445 e6 berbamine 66 µM 1.28847500255463 0.10845217577859 no 429 0.0987903325084169 688 6610268 A calcium/calmodulin antagonist. SGTC_2745 rifampicin 24.3 µM 1.28099731884719 0.109793857334057 no 430 0.100097303919081 402 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_414 piperonyl butoxide 100 µM 1.28026500275212 0.109925890685585 no 431 0.100225975804563 542 5794 A potent inhibitor of cytochrome P450. SGTC_1843 st055809 45.5 µM 1.27533249412951 0.110818169062764 no 432 0.101095790568108 530 16413835 SGTC_834 0312-0008 75.7 µM 1.27404100812461 0.111052650483722 no 433 0.101324441638083 594 6385573 YIL048W NEO1 SGTC_3289 9119912 71.43 µM 1.27334219482128 0.111179674654459 no 434 0.101448319977111 545 17014829 SGTC_1583 clindamycin 39.6 µM 1.26908406759958 0.111955928338076 no 435 0.102205541045456 534 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2258 7960471 200 µM 1.2673203702537 0.11227858154513 no 436 0.102520379845143 454 2974708 SGTC_2829 7992743 58.44 µM 1.26661269397484 0.112408231443343 no 437 0.102646905632315 582 16462845 SGTC_1281 0884-0031 11.8 µM 1.26629859502493 0.112465810230267 no 438 0.102703099890429 594 1548255 SGTC_518 1021-0119 62.6 µM 1.26536594132561 0.112636903021166 no 439 0.102870089198358 563 1097762 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.2652907341732 0.112650707663907 no 440 0.102883563440914 592 5282309 SGTC_630 4356-0227 183 µM 1.26414644331383 0.112860896943414 no 441 0.103088734759893 547 779312 SGTC_954 1189-0853 2.85 µM 1.26124043783093 0.11339594504001 no 442 0.103611116719868 592 2828194 SGTC_1241 0364-0022 50.8 µM 1.25962648857864 0.113693882440682 no 443 0.103902067664915 613 4563895 SGTC_1575 cyproterone acetate 48 µM 1.2587888918093 0.113848723787427 no 444 0.104053296821981 565 9880 An androgen receptor antagonist and liver toxin. SGTC_2748 diazoxide 86.69 µM 1.25519025967125 0.114515690446453 no 445 0.104704850297362 511 3019 A potassium channel activatior. SGTC_2506 ethyl hematommate 54.16 µM 1.25426842549853 0.114686988786923 no 446 0.104872228171697 491 3940691 An allergen. SGTC_1123 mangostin 811.285 nM 1.2542311825772 0.114693913222318 no 447 0.104878994455919 570 5281650 An antioxidant. SGTC_1488 4013-0813 75.9 µM 1.25382347892926 0.114769735472668 no 448 0.104953086618236 517 2910057 SGTC_81 0411-0046 9.971 µM 1.2516100716588 0.115181993891397 no 449 0.105355991408678 529 12925265 SGTC_1558 st069300 45.6 µM 1.25104054106305 0.115288241967783 no 450 0.10545984337336 495 24208000 SGTC_3292 9120825 59.784 µM 1.24926582610436 0.115619768433084 no 451 0.105783931395383 590 24824900 SGTC_1332 1480-0653 17.5 µM 1.24624336626619 0.11618593826273 no 452 0.106337531286378 577 5749438 SGTC_716 1683-5115 658 µM 1.24614032879121 0.116205273952671 no 453 0.106356440648757 672 723597 SGTC_1082 camptothecin 424.86 nM 1.24590315567555 0.11624978979436 no 454 0.106399975713411 514 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1279 0874-0590 65.2 µM 1.24551855301444 0.116322002916149 no 455 0.106470600025999 595 3523074 SGTC_2379 9035213 200 µM 1.24502105041041 0.116415461372724 no 456 0.106562006272974 634 646551 SGTC_1668 st014914 51.6 µM 1.24346032230362 0.116708997908465 no 457 0.106849126720672 560 2839556 SGTC_2743 auranofin 4.32 µM 1.23935604370084 0.11748342031555 no 458 0.107606836153674 557 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1290 0986-0249 10.2 µM 1.23603418086956 0.118112870044123 no 459 0.108222929269506 543 53329 SGTC_1734 st037168 69.4 µM 1.23424356880126 0.11845315533955 no 460 0.108556078421947 581 708907 SGTC_811 0416-0114 265 µM 1.23137549615411 0.118999642424981 no 461 0.109091228648579 571 6612453 SGTC_2260 7964312 200 µM 1.2273187784179 0.1197756519916 no 462 0.109851400183526 546 231951 SGTC_1166 k206-0078 225 µM 1.2263913281605 0.119953563979268 no 463 0.110025723895811 630 5404595 SGTC_1773 st048542 73.5835 µM 1.22386126591492 0.120439850628381 no 464 0.110502283862286 621 3237138 SGTC_88 0180-0332 8.668 µM 1.22239009913382 0.120723251493537 no 465 0.110780070794093 608 3101745 SGTC_535 2293-4129 48.2 µM 1.21964373441151 0.121253557809168 no 466 0.11129997982855 688 396118 YIL048W NEO1 SGTC_1684 st024538 14.6195 µM 1.21555887393368 0.122045346441953 no 467 0.112076504322618 611 6732859 SGTC_454 lyso-paf C-16 6.67 µM 1.21511001321803 0.122132572231993 no 468 0.112162067515025 569 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2810 7959871 45.46 µM 1.2110737550305 0.122918893271339 no 469 0.112933569448418 659 2974535 SGTC_1619 st003326 88.7 µM 1.20950249004171 0.123225956059007 no 470 0.113234927513909 573 2849032 SGTC_2740 felodipine 17.08 µM 1.20845479675235 0.123430998872996 no 471 0.113436186580574 533 3333 L-type calcium channel blocker SGTC_1872 amphotericin b 148 nM 1.20810832256137 0.123498859485476 no 472 0.11350279943953 614 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1472 k841-0093 193 µM 1.20757185805541 0.123603983245875 no 473 0.113605994710886 656 X1472 SGTC_3257 9139206 32.98 µM 1.20554869916517 0.124000998298713 no 474 0.113995774940913 547 4910041 SGTC_729 4092-0585 94.1 µM 1.20291645776908 0.124518871384425 no 475 0.114504325454675 578 2169061 SGTC_3099 9120367 49.47 µM 1.20189141644712 0.124720948815894 no 476 0.114702800242222 615 24824940 SGTC_3328 9140624 29.0385 µM 1.19928815262525 0.125235188057735 no 477 0.115207960099848 647 4904392 SGTC_770 0389-1121 67.2 µM 1.1989010232151 0.125311786453735 no 478 0.115283216923886 672 6753108 SGTC_1829 berberine 14.4 µM 1.19651692309602 0.125784231424964 no 479 0.115747449283113 603 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_577 r071-0003 38.6 µM 1.19557009129943 0.125972204515663 no 480 0.115932184383217 766 4568517 YMR134W ERG29 SGTC_576 1073-0113 22.7 µM 1.19424273514403 0.126236052172358 no 481 0.116191515378474 801 5439563 SGTC_1015 4130-4525 82 µM 1.19236914130804 0.126609134367014 no 482 0.116558267316236 623 1363237 SGTC_1792 st045773 43.6 µM 1.19151668767076 0.126779134424169 no 483 0.116725404736035 620 2919270 SGTC_1806 st050005 60.3 µM 1.19123971320395 0.126834404085004 no 484 0.116779746647765 615 5194765 SGTC_2314 7727897 200 µM 1.18975685266535 0.12713059103166 no 485 0.117070986371765 596 900724 SGTC_2738 aclarubicin 5.55 µM 1.18724750903218 0.127632903617591 no 486 0.117565003088068 534 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2282 7944268 200 µM 1.18672127043975 0.127738419195461 no 487 0.117668791072639 656 2970414 SGTC_3233 9132340 49.47 µM 1.18383233993819 0.128318755776377 no 488 0.11823971883967 615 17682950 SGTC_97 0535-0701 19.132 µM 1.18364673605837 0.128356102895564 no 489 0.118276465838021 591 2832013 YGL099W LSG1 SGTC_223 busulfan 5 mM 1.18338932694903 0.128407911116714 no 490 0.118327442641056 530 2478 A DNA alkylator. SGTC_2796 7949634 45.45 µM 1.18217944226285 0.128651616671565 no 491 0.118567253943498 614 2971588 SGTC_1200 1643-0193 18.4 µM 1.17973801031621 0.129144368044583 no 492 0.119052215594514 670 5403974 SGTC_62 0180-0423 3.232 µM 1.17944409833259 0.129203776079049 no 493 0.119110692054951 618 30102 YGL099W LSG1 SGTC_401 neomycin 50 µM 1.17872574114773 0.129349056378195 no 494 0.119253701084006 604 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1069 diphenylcyclopropenone 8.49 µM 1.17569738796343 0.129962753834236 no 495 0.11985791139092 717 65057 A dermal irritant. YDR527W RBA50 SGTC_3299 9121982 43.1275 µM 1.17542541724523 0.130017967324046 no 496 0.119912279816278 651 17594604 YPL160W CDC60 SGTC_707 0865-0008 204 µM 1.17518076314498 0.130067649065696 no 497 0.119961202353201 660 723043 SGTC_880 0833-0487 87.2 µM 1.17242450909396 0.130628267593095 no 498 0.12051333210765 621 76075 SGTC_237 nikkomycin 200 µM 1.17046618828673 0.13102760132222 no 499 0.120906706605085 665 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1926 methyl fluorone black 53.6 µM 1.16832061812819 0.131466085615922 no 500 0.121338730835576 581 72721 Reacts with homocysteine. SGTC_2670 beta-carotene 100 µM 1.16641389075099 0.131856607496088 no 501 0.121723572506275 555 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1521 st012942 49.4 µM 1.1663274126344 0.131874338258648 no 502 0.121741047005181 708 24207259 SGTC_783 0848-0141 92.7 µM 1.16498019974394 0.132150772124776 no 503 0.122013503870118 629 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2888 9058547 12.99 µM 1.16481596622866 0.132184498409373 no 504 0.122046747294482 549 16476514 SGTC_2853 9015042 58.44 µM 1.16352978158767 0.132448828937104 no 505 0.122307311088886 605 6457456 SGTC_606 k015-0008 38.6 µM 1.15989446788101 0.133197910035716 no 506 0.123045887686294 705 1970475 SGTC_3271 9137798 49.47 µM 1.15545019890479 0.134117635757351 no 507 0.123953057633689 577 6498326 SGTC_847 0342-0274 5.54 µM 1.15220506463156 0.134791954516455 no 508 0.124618408498012 681 18097 SGTC_1347 1493-0251 600 nM 1.15204770897812 0.134824711073192 no 509 0.124650734515903 696 3986378 SGTC_2315 7733312 200 µM 1.14872430500028 0.135517816424249 no 510 0.125334840233979 615 726316 SGTC_712 r015-0009 80.6 µM 1.14735890388973 0.135803281062829 no 511 0.125616659297717 602 6813872 YLR060W FRS1 SGTC_220 paclitaxel 373.376 µM 1.14523526983577 0.136248087425607 no 512 0.126055855874809 593 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_255 tunicamycin 200.472 nM 1.14462878789718 0.136375301073762 no 513 0.126181480933299 666 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_188 3229-0966 278.469 µM 1.14326155167168 0.136662386032703 no 514 0.126465006653446 777 5722370 SGTC_784 4579-0127 173 µM 1.14212740167643 0.136900842136408 no 515 0.126700533497901 706 1948547 SGTC_2002 4023503 131 µM 1.14080091774571 0.137180097225311 no 516 0.126976389316962 787 4736863 YCR052W RSC6 SGTC_2908 7930301 100 µM 1.14077275026903 0.137186031336964 no 517 0.126982251559228 751 2223178 SGTC_453 enantio-paf c16 10 µM 1.14034813315381 0.137275507715331 no 518 0.12707064610479 813 13871343 A lipid and platelet activating factor SGTC_2340 7987427 183.45 µM 1.13907596287678 0.137543821168001 no 519 0.127335736083666 660 2239331 SGTC_1565 sinapyl alcohol 95.1 µM 1.13842911377943 0.137680385322408 no 520 0.127470671441528 628 5280507 A phenol propionate derived from cinnamic acid. SGTC_1506 4226-2149 212 µM 1.13731402782878 0.137916021829188 no 521 0.127703516301078 719 991114 SGTC_813 k007-0158 173 µM 1.13600497706907 0.13819299724073 no 522 0.127977240662002 757 6523916 SGTC_2634 4'-methoxyflavone 100 µM 1.1331906095979 0.138789758450324 no 523 0.12856710837778 622 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3244 9134489 49.47 µM 1.13221672050351 0.138996670984129 no 524 0.12877166608296 659 16584271 SGTC_1487 3970-0795 2.82 µM 1.1322066413354 0.138998813502157 no 525 0.128773784312362 711 3765103 SGTC_769 0302-0231 76 µM 1.12881130060552 0.13972183715659 no 526 0.129488722244591 782 571869 YER009W NTF2 SGTC_1190 1486-1332 13 µM 1.12789485200287 0.139917428500602 no 527 0.12968216412924 665 4150046 SGTC_2787 5284540 71.43 µM 1.12579327562687 0.140366655894798 no 528 0.130126515551839 668 736958 SGTC_1439 4092-1168 46 µM 1.12454175213321 0.140634643035749 no 529 0.130391634185528 704 2886240 SGTC_562 3772-2733 112 µM 1.12408861526611 0.140731758230032 no 530 0.130487717278381 778 2876874 YIL048W NEO1 SGTC_3096 9117468 49.47 µM 1.11977900174182 0.141657658602902 no 531 0.131403974780692 563 41316311 SGTC_2365 9042475 200 µM 1.11955132214367 0.141706689002286 no 532 0.13145250447184 677 6464479 SGTC_858 0438-0351 2.77 µM 1.11680893420914 0.142298160467673 no 533 0.132038014010572 736 2799119 SGTC_3024 9090631 49.47 µM 1.11661317354927 0.142340445423927 no 534 0.132079878270093 653 25236383 SGTC_1330 1469-0054 61.8 µM 1.11618425172924 0.142433123685135 no 535 0.132171637042142 706 7102664 SGTC_1933 st074711 15.9 µM 1.11358424136429 0.142995788256916 no 536 0.132728795009811 719 17250958 SGTC_2995 9067767 71.4286 µM 1.11297355092788 0.143128164430687 no 537 0.132859894525988 617 11673567 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.11208817020868 0.14332023075234 no 538 0.133050121271945 548 88881 An O-methylated flavonoid and antioxidant. SGTC_1661 st013063 9.66 µM 1.11187349092564 0.143366827499779 no 539 0.133096273996267 750 721395 SGTC_185 k048-0037 25.491 µM 1.1110459472678 0.14354654391032 no 540 0.133274286177972 724 6827589 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.11034567445087 0.143698739840052 no 541 0.133425049149273 692 756377 SGTC_2096 5468907 200 µM 1.10846923545709 0.144107098100411 no 542 0.133829609190027 675 759785 SGTC_257 daunorubicin 18.5 µM 1.10550024744559 0.144754818424766 no 543 0.134471443622797 697 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1221 2958-7315 257 µM 1.10100960186003 0.145738226855159 no 544 0.135446239106082 683 4562705 SGTC_1867 st057372 64 µM 1.10063677061021 0.145820074764976 no 545 0.135527387664409 685 688837 SGTC_2263 7948595 193.29 µM 1.0961649396333 0.146804186452324 no 546 0.136503299878546 651 2971371 SGTC_421 streptovitacin 30 mM 1.09505496977374 0.147049145104885 no 547 0.136746277423397 744 91467 include heat shock SGTC_2524 avocatin b 10.57 µM 1.08831065541712 0.148543434028088 no 548 0.138228994075609 664 6710748 SGTC_721 1187-1332 279 µM 1.08712499353133 0.148807178239756 no 549 0.138490786756374 640 25730 SGTC_1320 1313-0481 95.3 µM 1.08683655044693 0.148871388176773 no 550 0.138554525694759 747 6813365 YLR208W SEC13 SGTC_2188 6126565 140.678 µM 1.08113621688708 0.150144130217864 no 551 0.139818262633747 679 874518 SGTC_3213 9129884 49.47 µM 1.08045085581559 0.15029764123539 no 552 0.139970729903284 628 17190742 SGTC_350 k064-0020 19.8 µM 1.07753270308219 0.150952435875726 no 553 0.140621174396261 770 2790705 SGTC_1821 st053465 65.6 µM 1.07543157756086 0.151425074442007 no 554 0.1410907752279 703 675086 SGTC_755 1995-0008 37.3 µM 1.07465948611889 0.15159899984889 no 555 0.141263604287991 757 689533 SGTC_2891 9063876 19.48 µM 1.07412183652356 0.151720192045246 no 556 0.141384039368918 664 6472478 SGTC_2703 st077852 53.4 µM 1.07103546127241 0.15241714075393 no 557 0.142076742600978 688 6281836 SGTC_2206 7254556 146.969 µM 1.0710165070491 0.152421427449123 no 558 0.142081003754527 682 4398905 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.07010661754224 0.152627302562046 no 559 0.142285660387479 749 2333 A French combination drug. SGTC_2466 5983409 37.09 µM 1.06569497401063 0.153628112651779 no 560 0.143280775187856 712 2879657 SGTC_178 4092-0806 87.505 µM 1.06553973362849 0.153663408907787 no 561 0.143315877467051 797 2169044 SGTC_642 0335-0876 158 µM 1.06323838019857 0.154187286259874 no 562 0.143836930663229 751 6812350 SGTC_870 0573-2213 57.6 µM 1.06251504370471 0.154352189431271 no 563 0.144000966110189 720 3916321 SGTC_117 lucigenin 22.078 µM 1.0560784703107 0.15582470613128 no 564 0.14546618286161 779 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1009 4106-0057 9.87 µM 1.05293917283773 0.1565462431611 no 565 0.146184435523938 798 2928005 SGTC_2766 oltipraz 83.91 µM 1.05264071449697 0.156614955235106 no 566 0.146252844804464 721 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.05193800437503 0.156776813893416 no 567 0.146413997040467 747 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_412 gemfibrozil 100 µM 1.05126513561671 0.156931902179753 no 568 0.146568417453634 708 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1559 coumarin 343 70.1 µM 1.05111897860665 0.156965602979651 no 569 0.146601974288072 706 108770 A hepatotoxic, DNA x-linker. SGTC_3146 9095609 49.47 µM 1.05088973433431 0.157018471582407 no 570 0.146654617879705 759 17173999 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.05072196234601 0.157057170791686 no 571 0.146693153031045 797 4174840 SGTC_1817 st052116 64.4 µM 1.05011151501132 0.157198032866117 no 572 0.1468334225672 742 4361398 SGTC_2290 7904846 200 µM 1.0498172040887 0.15726597543486 no 573 0.146901081924033 742 2962154 SGTC_2017 5132927 60.65 µM 1.04954822021339 0.15732808806155 no 574 0.146962937113767 740 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_902 1120-0002 2.07 µM 1.04834737954758 0.157605577822678 no 575 0.147239293938716 767 3280475 SGTC_3270 9137563 49.47 µM 1.04739663889348 0.15782550252155 no 576 0.14745834063089 704 17015724 SGTC_1995 st072814 61.1 µM 1.04699202151742 0.157919159454928 no 577 0.147551628992168 735 5769371 SGTC_1848 st056003 16.4 µM 1.04696019145418 0.157926528719456 no 578 0.147558969391244 785 146492 SGTC_2531 methyl deoxycholate 70.07 µM 1.04667719706721 0.157992057225931 no 579 0.147624242088813 698 16667744 Haematoxylin. SGTC_359 0081-0058 15.9 µM 1.04497254558837 0.158387153803534 no 580 0.148017829273332 692 3494159 SGTC_3001 9076041 71.4286 µM 1.04346648897245 0.158736759781328 no 581 0.148366146723271 730 16004211 SGTC_392 N-ethylmaleimide 8.33 µM 1.04315036245582 0.158810207481258 no 582 0.14843932932666 727 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1224 0823-0416 294 µM 1.04256144570442 0.158947093678701 no 583 0.14857572664494 777 3598164 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.04214119924156 0.159044821874809 no 584 0.1486731099396 743 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3059 1327-0034 3 µM 1.04100695904366 0.159308785587457 no 585 0.148936159239515 751 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1944 st076371 56.9 µM 1.03971212776135 0.159610473012831 no 586 0.149236832200132 738 24208455 SGTC_438 sphingosine 6.67 µM 1.0394225954727 0.159677983305138 no 587 0.149304119946188 657 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3232 9132874 49.47 µM 1.03936442605715 0.159691548931298 no 588 0.149317641050434 736 3784940 SGTC_640 3381-0960 37.1 µM 1.03918252891298 0.159733973832479 no 589 0.149359927139647 805 1745025 SGTC_1556 plumbagin 1.48 µM 1.03559232978556 0.160572845364956 no 590 0.150196185923805 699 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2358 9037157 4 µM 1.03405824595241 0.160932169186466 no 591 0.150554467218058 770 2388925 SGTC_1227 3909-8010 46.6 µM 1.03255361368691 0.161285104104124 no 592 0.150906422703696 759 15982272 SGTC_1775 st081588 35.1725 µM 1.03234877452332 0.161333191334516 no 593 0.150954379898407 800 1426443 YGL099W LSG1 SGTC_75 0159-0059 199.013 µM 1.03086213762328 0.161682468498848 no 594 0.151302737066297 740 5377270 SGTC_1377 2944-0135 198 µM 1.03081909452722 0.161692588573561 no 595 0.151312831126244 788 1894137 SGTC_213 1246-0773 967 nM 1.03075433458439 0.161707815381113 no 596 0.15132801885962 795 6251622 SGTC_2680 butyl paraben 22.24 µM 1.0302583227731 0.16182447211356 no 597 0.151444378944169 762 7184 An antifungal and steroid mimetic. SGTC_2866 9034245 58.44 µM 1.02820764595617 0.162307351463739 no 598 0.151926081288968 745 6462273 SGTC_949 1165-0505 146 µM 1.02758053626938 0.162455206050847 no 599 0.152073591854042 822 6244267 SGTC_1217 1183-1422 255 µM 1.02317150412035 0.163497203775151 no 600 0.153113381797243 828 2849664 SGTC_790 1575-0012 79.1 µM 1.02162041923863 0.163864805385892 no 601 0.153480294740791 807 378741 YLR208W SEC13 SGTC_2434 5670830 169.91 µM 1.02114578888005 0.163977398188525 no 602 0.153592685986942 766 1549830 SGTC_2118 5526350 200 µM 1.02105473297263 0.163999004397767 no 603 0.153614254020281 810 743594 SGTC_1306 1185-0270 9.02 µM 1.02099912856215 0.16401219940365 no 604 0.153627425791471 829 1548076 SGTC_2199 6590217 200 µM 1.019809885247 0.164294573425285 no 605 0.153909317026344 711 703109 SGTC_801 0866-0028 10.1 µM 1.01674397828108 0.165023995540213 no 606 0.154637619349852 812 6849771 SGTC_1770 st043884 66.3 µM 1.01612447877071 0.16517163738422 no 607 0.154785056813051 787 670149 SGTC_1669 st015249 58.4 µM 1.01579087596859 0.16525117847533 no 608 0.15486449089628 818 722793 SGTC_909 3448-9333 149 µM 1.01544109095025 0.165334604518332 no 609 0.15494780703616 742 3344074 SGTC_3057 9095946 49.47 µM 1.0136602708769 0.165759764375864 no 610 0.155372443821651 810 24540043 SGTC_2084 5306078 60.6385 µM 1.01352248239073 0.165792689965766 no 611 0.155405331482191 766 679340 SGTC_3062 9077494 49.47 µM 1.01306460167049 0.165902134357373 no 612 0.155514652457204 759 16459633 SGTC_2949 9072542 2.23 µM 1.01180160871196 0.166204261718457 no 613 0.155816460326145 790 16457352 SGTC_826 1683-5028 118 µM 1.0106171935876 0.166487914763078 no 614 0.156099841701754 783 722377 SGTC_3201 9113999 49.47 µM 1.01026392617524 0.166572578491336 no 615 0.156184429642882 751 16649224 SGTC_54 0159-0055 9 µM 1.00715513632425 0.167318826091689 no 616 0.15693011432195 794 3319099 SGTC_1697 st025554 27.742 µM 1.00551138896292 0.167714267900835 no 617 0.157325334112186 758 1269519 SGTC_203 k066-0004 30.888 µM 1.00374909991064 0.168138895638187 no 618 0.157749782045827 940 6795412 SGTC_962 1254-0300 21.5 µM 1.00269594061299 0.168392986800693 no 619 0.158003794560208 795 7340576 SGTC_2474 5321570 43.32 µM 1.00215980688925 0.168522432253453 no 620 0.158133208261585 803 2841384 SGTC_1039 k821-0043 94 µM 1.00067608829157 0.168880998349247 no 621 0.158491715659553 824 15992768 SGTC_214 4373-3496 70 µM 1.00001794340282 0.169040207185555 no 622 0.158650912192229 972 3779166 SGTC_633 0437-0093 97.7 µM 0.999551967283344 0.169152987615397 no 623 0.158763689018307 795 2831118 SGTC_1093 fluphenazine 7.97 µM 0.99851660961941 0.169403748636285 no 624 0.159014457198375 816 6602611 An atypical antipsychotic. SGTC_1433 4060-0023 7.6 µM 0.998371449617722 0.169438925083064 no 625 0.159049636321747 811 3840627 SGTC_797 k781-0471 270 µM 0.996022082044259 0.170008896235972 no 626 0.15961970806819 819 23738129 SGTC_1295 1013-0063 9.78 µM 0.995584375878773 0.170115222125898 no 627 0.159726064632301 839 6826038 SGTC_947 3447-0010 211 µM 0.993687981912735 0.17057637897195 no 628 0.160187397736224 788 748350 SGTC_2113 5491891 107.031 µM 0.99203240867744 0.170979627835431 no 629 0.160590858149707 813 789979 SGTC_2489 cantharidin 73.42 µM 0.989132296025226 0.171687478344273 no 630 0.161299209071141 797 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3230 9131665 49.47 µM 0.986896484974635 0.1722344642121 no 631 0.161846693801368 713 15943720 SGTC_2921 7974240 10.71 µM 0.984205783278372 0.172894210629916 no 632 0.162507171415684 804 2979074 YDR527W RBA50 SGTC_2346 9031566 143.75 µM 0.981912483294532 0.173457785604169 no 633 0.163071482648138 825 4771086 SGTC_3008 9078912 71.4286 µM 0.981684595983735 0.173513852362181 no 634 0.163127628260479 793 16648731 SGTC_1567 st069303 68.4 µM 0.979921431011778 0.173948030831431 no 635 0.163562451646201 821 5581319 SGTC_2250 alverine citrate 130 µM 0.979125589313996 0.174144232522149 no 636 0.163758964649993 868 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2906 7926292 26.41 µM 0.978614042988285 0.174270420095147 no 637 0.1638853589717 811 2966319 SGTC_2882 9058044 58.44 µM 0.978150173607023 0.174384897001124 no 638 0.164000027854835 788 18076804 SGTC_175 3793-3120 23.7 µM 0.977234412172683 0.174611035178959 no 639 0.164226557595883 769 5322297 SGTC_2800 7887935 81.82 µM 0.972772568794243 0.175715505227236 no 640 0.165333174488624 788 2961002 SGTC_1924 st058459 75.1 µM 0.970963633363413 0.176164541348246 no 641 0.165783194228299 811 688683 SGTC_1948 st076329 66.6 µM 0.969336342618201 0.176569107400571 no 642 0.166188701072628 783 24208413 SGTC_2991 9074669 71.4286 µM 0.968648014421897 0.176740411610476 no 643 0.16636041919315 870 17333109 SGTC_2373 9071805 200 µM 0.966720660676782 0.177220630811191 no 644 0.166841847917976 847 10149009 SGTC_2898 9056270 58.44 µM 0.96548216870328 0.177529647790762 no 645 0.167151681480709 782 19154699 SGTC_1130 3454-2858 15.9 µM 0.964762359487027 0.177709404053684 no 646 0.16733192650521 803 715628 YIL048W NEO1 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.963290865745834 0.178077233911705 no 647 0.167700787962786 823 140250 A respiratory chain inhibitor. SGTC_2012 4023501 200 µM 0.963207880952168 0.178097991940434 no 648 0.167721605466787 764 3477460 SGTC_1789 tunicamycin 25 nM 0.96314791672696 0.178112992494575 no 649 0.167736649083646 839 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2463 5473429 200 µM 0.961369385270473 0.178558269163433 no 650 0.16818323592711 815 5399405 SGTC_2318 6029776 164 µM 0.961219844644058 0.178595740377553 no 651 0.168220820208049 832 818325 SGTC_910 3454-3003 490 µM 0.959423372412135 0.179046279293775 no 652 0.168672752697974 858 820824 SGTC_1381 2324-0066 62.1 µM 0.958445464348377 0.179291830062575 no 653 0.168919089451229 797 10885928 SGTC_3327 9140648 26.9345 µM 0.95699004874304 0.179657673940579 no 654 0.169286138903794 842 8029710 SGTC_1047 2043-3044 82 µM 0.955783564075938 0.179961300053086 no 655 0.169590796885606 856 669592 SGTC_3294 9122953 26.2835 µM 0.952863988036196 0.180697378245157 no 656 0.1703294941588 867 16459826 SGTC_3165 9101544 49.47 µM 0.952372791536101 0.180821403068859 no 657 0.170453976618393 855 5002184 SGTC_1518 st038567 90.8 µM 0.943455692900201 0.183082198892837 no 658 0.172723933993872 861 77966 SGTC_2220 6782180 200 µM 0.940347652470937 0.183874322181689 no 659 0.173519632028519 780 833803 SGTC_2663 amphotericin b 100 µM 0.940026482878627 0.183956297805591 no 660 0.173601988325004 836 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.938038633786004 0.184464184439689 no 661 0.174112278150565 930 16486 A toxic proline analog. SGTC_2361 9034121 116 µM 0.93613368293566 0.184951708511911 no 662 0.174602181292064 840 6496917 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.935940370524674 0.185001226649758 no 663 0.174651945021738 900 3256 An antibiotic and ribosome inhibitor. SGTC_279 1273-0055 2.93 µM 0.935890535707664 0.185013993473498 no 664 0.174664775282151 934 2847562 SGTC_3010 9080089 71.4286 µM 0.934510462743553 0.185367761898112 no 665 0.17502032074285 884 17027233 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.932990153926924 0.185757964213686 no 666 0.175412526031145 929 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_667 1498-1044 59 µM 0.93086979327129 0.186303025909994 no 667 0.175960460763379 907 6739982 SGTC_973 1325-0077 65.9 µM 0.9296034070411 0.186629036381693 no 668 0.176288231380923 950 2835149 SGTC_217 ketoconazole 989 nM 0.929242805856789 0.186721931842976 no 669 0.17638163409521 870 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2324 6149169 200 µM 0.926981551885685 0.187305111995705 no 670 0.176968056361986 843 2888231 SGTC_266 formosanin C 406 nM 0.924765904582785 0.187877621104952 no 671 0.177543844762587 886 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2976 9009005 19.48 µM 0.923521522232838 0.188199634900182 no 672 0.177867744895718 897 2993148 SGTC_235 0330-0087 5 mM 0.922919418778854 0.188355565804627 no 673 0.178024600039284 918 46494818 YHR062C RPP1 SGTC_283 0987-0079 11.7 µM 0.92230304275284 0.188515275501154 no 674 0.178185263670444 925 411556 SGTC_1868 st057644 42.7 µM 0.922060880802465 0.188578045124482 no 675 0.178248410232088 953 688665 SGTC_2305 7443522 69.23 µM 0.917401667164501 0.189788245169555 no 676 0.179466099726296 921 5415886 SGTC_2653 dihydrofissinolide 100 µM 0.916870455992955 0.189926526433427 no 677 0.179605263548466 891 6857746 SGTC_600 1495-0418 41.6 µM 0.915487107329587 0.190286920880031 no 678 0.179967983872627 861 5377768 SGTC_2053 5265679 138 µM 0.909962188497364 0.19173047530425 no 679 0.18142122550443 895 764595 SGTC_2809 7964133 12.99 µM 0.907913326859355 0.192267503292287 no 680 0.181962007986774 885 1253665 SGTC_1291 0993-0025 5.79 µM 0.906767437309524 0.192568253648682 no 681 0.182264896467217 924 4353356 SGTC_1201 1889-3372 45.9 µM 0.905913592434808 0.192792540765973 no 682 0.182490794661201 879 5392199 SGTC_791 1348-1292 225 µM 0.905181657812589 0.19298493160658 no 683 0.182684578713803 967 5437054 SGTC_3199 9111318 49.47 µM 0.905036182696733 0.193023184066094 no 684 0.18272310941799 878 8548020 SGTC_256 clotrimazole 625 nM 0.902946077498523 0.193573285026906 no 685 0.183277257047018 890 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_342 k048-0088 23.3 µM 0.897026453560816 0.19513646960168 no 686 0.184852400694886 894 6820570 SGTC_3353 9151644 39.2805 µM 0.893633421981729 0.19603591056948 no 687 0.185759029032254 911 4909158 SGTC_5 0352-0601 109.883 µM 0.893573814687595 0.196051733998998 no 688 0.185774980896528 876 762456 SGTC_1264 0783-0040 158 µM 0.891233564873675 0.196673591883937 no 689 0.186401940561454 881 2855798 SGTC_2439 5492030 7.2 µM 0.885362520787745 0.198238912575013 no 690 0.187980569868866 923 5722370 SGTC_3115 9123671 49.47 µM 0.884653737084202 0.198428393837668 no 691 0.188171707198982 993 3286988 SGTC_2409 alverine citrate 63.97 µM 0.883061528704484 0.198854441922752 no 692 0.188601514312868 912 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1296 1068-0102 11.9 µM 0.881669474095941 0.199227383657652 no 693 0.188977786611693 923 767053 SGTC_1299 1079-1439 3.74 µM 0.881605660557943 0.199244489868945 no 694 0.188995046486441 908 323161 SGTC_1959 st077091 55.8 µM 0.881234738062311 0.19934393892579 no 695 0.189095390439585 978 821356 YKL052C ASK1 SGTC_1132 3456-3614 2.5 µM 0.881069025125421 0.199388378337444 no 696 0.189140230598529 1022 3125502 SGTC_1353 1498-1206 8.11 µM 0.879830796822188 0.199720624070743 no 697 0.18947548923354 958 6756808 SGTC_1169 aniline yellow 25.8 µM 0.878217108700166 0.200154114017348 no 698 0.189912954575628 906 6051 A DNA damaging agent. SGTC_1401 3807-4679 7.6 µM 0.876831982109799 0.200526655432661 no 699 0.190288952491301 895 3291456 SGTC_2049 5262831 67.185 µM 0.876340151769861 0.200659037443091 no 700 0.190422571658462 929 763417 SGTC_3141 9094609 49.47 µM 0.876175171746162 0.200703455535995 no 701 0.190467405897856 860 25236309 YDL196W YDL196W SGTC_2910 7948405 25.97 µM 0.874991701268896 0.201022258025093 no 702 0.190789210571985 911 2971328 SGTC_1030 k029-0042 36.7 µM 0.874877640493424 0.20105299968147 no 703 0.190820243149865 954 6080581 SGTC_3111 9122088 49.47 µM 0.874580779726009 0.201133022804597 no 704 0.190901024740647 840 16876704 SGTC_2964 9083345 53.42 µM 0.873714551832008 0.201366636251939 no 705 0.191136862101758 881 17741579 SGTC_530 4358-1714 28 µM 0.872932947598095 0.201577567018274 no 706 0.191349813250876 972 1564641 SGTC_1657 st012939 43.4 µM 0.872313200203448 0.201744911692553 no 707 0.191518769181512 913 24207257 SGTC_1000 4048-0884 8.67 µM 0.871936304236816 0.201846722106345 no 708 0.191621563478268 898 13040088 SGTC_849 0386-0493 241 µM 0.867672207644113 0.203000718336432 no 709 0.192786902324913 937 726119 SGTC_92 0063-0024 660.874 µM 0.864199056527866 0.203943565348037 no 710 0.193739275210969 1044 3594437 SGTC_1178 0988-0033 191 µM 0.862134796939823 0.204505178610798 no 711 0.194306672496276 952 5392207 SGTC_1098 clofazimine 15.1 µM 0.859244025045821 0.205293202194657 no 712 0.195102949469981 980 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_889 0919-1524 82.7 µM 0.858454781434953 0.20550866284106 no 713 0.19532069462025 906 3905452 SGTC_664 1222-0054 14.9 µM 0.8561086792349 0.206149932521347 no 714 0.195968834161899 974 6813991 SGTC_1260 0700-1617 7.75 µM 0.852703741460124 0.207082725409585 no 715 0.196911807768974 955 2853078 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.852492921148406 0.207140562235929 no 716 0.196970283141109 1032 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2016 5121758 140 µM 0.851349237611607 0.20745448893187 no 717 0.197287690563915 1038 2795203 SGTC_763 3453-1109 128 µM 0.850545977983849 0.207675141583883 no 718 0.197510804714763 1001 1560353 SGTC_1116 jasmonic acid  1.58368 µM 0.84948713711505 0.207966213270424 no 719 0.197805142326739 970 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1807 st050092 58.9 µM 0.849459397222004 0.207973842107185 no 720 0.197812857049964 926 5008496 SGTC_613 3914-0030 117 µM 0.849179917819974 0.208050711849085 no 721 0.197890593022688 765 1145395 SGTC_1061 3448-9325 110 µM 0.849015729039302 0.20809587916539 no 722 0.197936270017579 963 723482 SGTC_687 k029-0044 34.9 µM 0.848866835787873 0.208136843779823 no 723 0.197977697331999 1025 5829338 SGTC_1560 lithocholic acid 53.1 µM 0.848486722843847 0.20824144485004 no 724 0.198083481805665 928 9903 A bile acid which acts as a detergent. SGTC_116 0155-0182 31.788 µM 0.846395145412397 0.208817568519533 no 725 0.198666172881695 1018 771486 SGTC_650 1328-0195 38 µM 0.845475387390045 0.209071212295314 no 726 0.198922734492943 991 2780821 SGTC_2208 7283366 200 µM 0.842892351104429 0.2097845116555 no 727 0.199644325874541 1004 898663 SGTC_1660 st012960 28.1 µM 0.842523390349156 0.209886515944446 no 728 0.199747526351174 943 24207266 SGTC_362 0310-0100 9.03 µM 0.84079304152004 0.210365283530353 no 729 0.200231943036622 957 790235 SGTC_799 1310-0557 151 µM 0.836927416122134 0.211437170875395 no 730 0.201316684330876 975 5354492 SGTC_2902 5787006 60.46 µM 0.836338357481175 0.211600789504254 no 731 0.201482290071626 943 591003 SGTC_1097 itavastatin 7.23 µM 0.83625150346765 0.211624920594318 no 732 0.201506714787496 1034 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1380 2291-0730 164 µM 0.83615424387916 0.211651944629774 no 733 0.201534067820472 939 2999191 SGTC_2960 9079389 5.97 µM 0.83479961589905 0.212028544342657 no 734 0.201915271085057 995 16457355 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.833887140864523 0.212282441990786 no 735 0.202172292072661 1027 23847180 SGTC_1836 st055642 81 µM 0.833362535565392 0.212428494673882 no 736 0.202320148607807 1028 8571 SGTC_2189 6047310 154.431 µM 0.833073022133577 0.2125091217645 no 737 0.202401773741441 956 711535 SGTC_2900 5328528 85.29 µM 0.831265506141225 0.21301290402641 no 738 0.20291182814038 1080 795359 SGTC_561 1550-0330 72.9 µM 0.829780418368136 0.213427341587891 no 739 0.203331472000227 968 6812934 SGTC_2717 st081029 62.2815 µM 0.829722028989773 0.213443645677313 no 740 0.203347981763446 983 5292846 SGTC_41 0478-0632 82.643 µM 0.828395682157708 0.21381419752814 no 741 0.203723225526673 1057 3750424 SGTC_2435 5706476 10.6 µM 0.82824484624231 0.213856361444444 no 742 0.203765925437396 1037 5725375 SGTC_211 3455-0679 143.504 µM 0.827609562003294 0.214033998747903 no 743 0.203945825637467 1021 748649 SGTC_1540 guanosine 70.6 µM 0.827537609035778 0.214054123550478 no 744 0.203966207290267 952 6802 Guanosine is a purine nucleoside SGTC_1706 st031321 9.9705 µM 0.827497885568816 0.214065234431753 no 745 0.203977460020383 1034 6103185 SGTC_2557 derrustone 83.84 µM 0.826309945816582 0.214397663067542 no 746 0.20431414650692 1040 629853 An antioxidant. SGTC_2673 kobusone 100 µM 0.823817795661353 0.215096031794755 no 747 0.205021547246155 1036 6710676 An epoxy ketone and protein crosslinker. SGTC_1393 3470-5649 58.2 µM 0.823769320775556 0.215109628866754 no 748 0.205035321337636 897 4108395 SGTC_2387 9077560 195.08 µM 0.8235353688785 0.215175258745012 no 749 0.205101806273895 977 5303272 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.821814728656133 0.215658302149611 no 750 0.205591174894984 999 2724 A muscle relaxant with antifungal properties. SGTC_135 0933-0004 26.348 µM 0.820925849306911 0.215908087509653 no 751 0.205844253059437 943 21230617 YGL099W LSG1 SGTC_1820 st053765 18.6 µM 0.81927500687146 0.21637243781649 no 752 0.206314764407117 1018 3690829 SGTC_2696 st077691 74.316 µM 0.818406658678966 0.21661691931074 no 753 0.206562510419904 936 757133 SGTC_2453 5731132 22.18 µM 0.817892103478061 0.216761866546436 no 754 0.206709399845687 1045 1362040 SGTC_2645 abamectin 100 µM 0.817766189838703 0.216797344232718 no 755 0.206745353670823 997 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.813311189394307 0.218054753610743 no 756 0.208019831658562 998 4330530 SGTC_2655 perillic acid 100 µM 0.812611731572348 0.218252554446834 no 757 0.208220351617304 1006 5702197 An apoptosis inducer. SGTC_918 glabranin 770.725 nM 0.812245806445735 0.218356076196455 no 758 0.208325300138218 1018 124049 Also referred to as licorice root. SGTC_105 0111-0055 734.78 µM 0.811987268109426 0.218429234822547 no 759 0.208399468585183 921 5179370 SGTC_2467 5474540 200 µM 0.808449878211613 0.21943162749009 no 760 0.209415824256126 1033 5413519 SGTC_804 1595-0054 20.9 µM 0.80821896669222 0.219497152813905 no 761 0.209482270536081 982 761523 Stimulates phospholipase C. SGTC_2953 9074162 66.49 µM 0.805784271528418 0.220188725357322 no 762 0.210183624297533 967 16451992 SGTC_2148 5546263 113.568 µM 0.805779714957785 0.220190020816716 no 763 0.210184938183907 1027 792097 SGTC_886 0866-0150 153 µM 0.805365818262348 0.220307712271313 no 764 0.210304305345894 1087 271463 SGTC_1618 st003135 44.5 µM 0.803109656521893 0.220949885243067 no 765 0.210955678400268 1020 1270615 SGTC_2741 miltefosine 3.04 µM 0.803074213073992 0.220959982078785 no 766 0.210965920652585 936 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2881 9058953 51.95 µM 0.802403342388591 0.221151143963421 no 767 0.21115984014525 1071 17122249 SGTC_1390 3413-2614 145 µM 0.801839096104354 0.221311996889347 no 768 0.211323020011645 1091 3421432 SGTC_1751 st044839 27.194 µM 0.801716616165996 0.221346921784571 no 769 0.211358450930374 1051 5291326 SGTC_308 4092-1169 104 µM 0.800744368865547 0.221624267830411 no 770 0.21163982542357 1051 2268590 YDL196W YDL196W SGTC_177 1327-0068 8.361 µM 0.800288262919241 0.221754446322454 no 771 0.211771900879961 1023 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3180 9109287 49.47 µM 0.797757254153386 0.222477622013186 no 772 0.212505685762349 991 18891271 SGTC_1256 0570-0116 285 µM 0.794956725848637 0.223279371632401 no 773 0.21331933753612 1026 410638 SGTC_1018 4259-0013 28.1 µM 0.794645909488806 0.223368455004532 no 774 0.213409752443003 1037 6801262 SGTC_1011 4112-3381 17.4 µM 0.793896065971972 0.223583451596369 no 775 0.213627970057759 1032 2877139 SGTC_3264 9137442 49.47 µM 0.793882980485455 0.223587204537047 no 776 0.213631779317573 1009 17015726 SGTC_1735 st034310 56.75 µM 0.792878160652439 0.223875495623156 no 777 0.213924406276502 1010 871153 SGTC_3068 9116768 49.47 µM 0.79109528057177 0.22438753819288 no 778 0.214444196489254 1038 41904888 SGTC_1360 1598-0022 39.8 µM 0.790584671197114 0.224534307391455 no 779 0.214593197396335 1088 761525 SGTC_2591 skatole 100 µM 0.790547320238046 0.224545045662284 no 780 0.214604099140146 1034 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1787 fluconazole 80 µM 0.789447489926441 0.224861373632836 no 781 0.214925254400252 1011 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_940 3232-1287 54.8 µM 0.788270652594881 0.225200129610655 no 782 0.215269204992397 1055 1585493 YIL048W NEO1 SGTC_2215 7188065 200 µM 0.787978040968397 0.225284403553204 no 783 0.21535477524405 1060 940217 SGTC_1897 st060201 15 µM 0.787592776916299 0.225395389195803 no 784 0.215467470518293 1009 611878 SGTC_3215 9129942 49.47 µM 0.785303974967446 0.226055377858058 no 785 0.216137682901973 1008 17682944 SGTC_1720 st037298 9.481 µM 0.784125783294379 0.226395541343489 no 786 0.216483153930304 1025 597396 SGTC_1308 1187-1617 41.4 µM 0.781753289446919 0.227081396070453 no 787 0.217179788619409 1093 2882570 SGTC_2600 tangeritin 87.95 µM 0.779995744996559 0.22759023195429 no 788 0.217696689856726 1047 68077 A bioactive flavone. SGTC_2861 9024595 19.48 µM 0.779982807692937 0.227593979879433 no 789 0.217700497402101 1019 16482810 SGTC_1071 trifluoperazine 6.31 µM 0.777108746957721 0.228427453603044 no 790 0.218547306909465 1088 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2737 bleomycin 30.5 nM 0.77687988282831 0.228493897531386 no 791 0.218614820565521 1117 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1065 prochlorperazine maleate 2.48 µM 0.776430783054434 0.228624311914408 no 792 0.218747337412845 1133 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_877 0771-0151 33.1 µM 0.776109592579119 0.228717608264262 no 793 0.218842140131916 1076 6166523 SGTC_1399 3562-5772 25 µM 0.77444020090972 0.229202861385423 no 794 0.219335259074078 998 23847490 SGTC_2514 salinomycin 42.74 µM 0.773960848225007 0.229342304616334 no 795 0.219476972211749 1135 23682228 A polyether potassium ionophore. SGTC_3091 9116372 49.47 µM 0.773657157588817 0.229430672530723 no 796 0.219566780818826 1043 17169793 SGTC_2714 st079313 56.9 µM 0.771881337688252 0.229947782550048 no 797 0.220092355749733 1056 2939799 SGTC_820 1582-0060 59.9 µM 0.770497327582909 0.230351251404636 no 798 0.220502469835419 1049 3848840 SGTC_2493 resveratrol 26.09 µM 0.770186439479399 0.230441936419106 no 799 0.220594653340239 1024 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1286 0929-0070 131 µM 0.766560341910659 0.231501129564088 no 800 0.221671481066884 1111 1420408 SGTC_3277 9138724 49.47 µM 0.763632016903776 0.232358478659174 no 801 0.222543281995799 981 15943418 SGTC_710 3448-4187 58 µM 0.763441061659715 0.2324144474285 no 802 0.222600199704578 1118 3946412 SGTC_674 0498-0004 451 µM 0.762531123939195 0.232681252132438 no 803 0.222871537282771 1059 4231473 SGTC_717 1532-0246 73.2 µM 0.762093171151211 0.23280972582752 no 804 0.223002199130769 1076 9561992 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.76197016530489 0.232845816749706 no 805 0.223038905387371 1092 6708514 SGTC_959 1222-0044 107 µM 0.761846116502761 0.232882216831544 no 806 0.223075926357512 1092 6083612 SGTC_147 4466-0538 29.23 µM 0.760810460137949 0.233186236501019 no 807 0.22338514287653 1211 6742687 YHR072W ERG7 SGTC_806 3966-4455 5.86 µM 0.760702796203685 0.233217854171113 no 808 0.223417302148259 992 714982 SGTC_992 3909-8734 162 µM 0.759047177792782 0.233704359195745 no 809 0.223912167792916 1119 4288319 SGTC_1832 st054113 55 µM 0.757835540409546 0.2340607562044 no 810 0.224274721538262 1084 1251267 SGTC_1243 0416-0003 5.65 µM 0.755702864162276 0.234688802713649 no 811 0.224913683226771 1090 2141977 SGTC_1941 st076221 61.8 µM 0.753416372862286 0.235363179619547 no 812 0.225599873532043 1124 2828568 SGTC_68 0986-0284 82.829 µM 0.753383063754304 0.235373011693796 no 813 0.225609878550087 980 423278 YIL048W NEO1 SGTC_1471 k673-0312 37 µM 0.749474102216952 0.236528419309429 no 814 0.226785751113556 1141 24099884 SGTC_3117 9124945 49.47 µM 0.74917442194657 0.236617127185022 no 815 0.226876041787925 1043 17592065 SGTC_2789 5281112 71.43 µM 0.748184617665473 0.236910247583162 no 816 0.227174403982014 1102 765948 SGTC_2461 5755302 26.15 µM 0.74804260311315 0.236952320107215 no 817 0.227217230351095 1106 2788904 SGTC_3015 9080845 49.47 µM 0.747878556165865 0.237000924950661 no 818 0.227266706544014 1158 5296973 SGTC_1088 bifonazole 369 nM 0.747222569160895 0.237195339590838 no 819 0.227464611425012 1067 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1338 1486-1223 76 µM 0.744791740775276 0.237916526592233 no 820 0.228198814307919 1132 3444526 SGTC_449 xestospongin c 11.1929 µM 0.744685496892546 0.237948074812158 no 821 0.228230934372292 1088 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_529 4076-0302 30.3 µM 0.743182512046784 0.238394619043022 no 822 0.228685594801233 1070 5816522 SGTC_79 0052-0007 94.094 µM 0.741366545980506 0.238934763165232 no 823 0.229235611445406 1125 2801472 SGTC_899 1083-0020 478 µM 0.740940819597377 0.239061488730375 no 824 0.229364661960737 1119 767123 SGTC_3194 9111903 49.47 µM 0.740300010640471 0.239252306972208 no 825 0.229558987255656 1123 17087251 SGTC_35 0133-0054 64.071 µM 0.739992733276422 0.239343836649459 no 826 0.22965220181678 1104 99677 SGTC_3104 9120930 49.47 µM 0.739386529124071 0.239524464666237 no 827 0.229836159895574 1083 17014836 SGTC_2940 9060638 45.86 µM 0.739255894646854 0.23956339899855 no 828 0.229875812899737 1102 4027022 SGTC_262 fenpropimorph 62.5 µM 0.738943510921832 0.239656515929448 no 829 0.229970649897002 1055 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3168 9103419 49.47 µM 0.738069394383115 0.239917181979171 no 830 0.230236140452696 1085 16649256 SGTC_901 1112-0062 60.1 µM 0.73695889994591 0.240248560018714 no 831 0.230573671844513 1157 1908457 SGTC_3153 9100258 49.47 µM 0.736936001796582 0.240255395583926 no 832 0.230580634575538 1075 25236848 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.735808483032081 0.24059211401427 no 833 0.23092362897422 1168 688669 SGTC_1822 st052468 42 µM 0.735629232670484 0.240645668401168 no 834 0.23097818367291 1130 2873678 SGTC_1419 3993-2473 62.6 µM 0.735519946526459 0.240678322857776 no 835 0.231011448350306 1156 704026 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.733340623025764 0.241330003185664 no 836 0.231675352137974 1083 689007 SGTC_189 3970-0742 2.116 µM 0.732304586810484 0.241640143681526 no 837 0.231991340170145 1155 2891807 SGTC_2849 9019321 12.99 µM 0.732187527853168 0.241675199225909 no 838 0.23202705789424 1094 16489627 SGTC_170 4197-0004 226 µM 0.73118487727212 0.241975575187859 no 839 0.232333117983027 1106 218692 SGTC_2270 7924575 90.91 µM 0.730950274055986 0.242045887286733 no 840 0.23240476325833 1133 1262135 SGTC_507 nimesulide 162 µM 0.729765939900626 0.242401008971381 no 841 0.232766633593944 1133 4495 A COX2 inhibitor. SGTC_2920 7982904 15.77 µM 0.727823961945166 0.242983919967753 no 842 0.233360677154059 1093 6456808 SGTC_520 3584-0023 682 µM 0.727817456353565 0.242985873982732 no 843 0.23336266860209 1081 1340790 SGTC_544 k015-0020 52.4 µM 0.72737590087772 0.243118519144385 no 844 0.233497856637588 1125 3008304 SGTC_1908 st060353 56.5 µM 0.726563498689189 0.243362670509839 no 845 0.233746697728901 1163 4227716 SGTC_501 nsc-95397 161 µM 0.726004639407565 0.243530701475059 no 846 0.233917963213711 1140 262093 SGTC_2612 dictamnine 15.46 µM 0.725303735762093 0.243741529150742 no 847 0.234132857213378 1091 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3065 9113888 49.47 µM 0.72457779736274 0.243959990960447 no 848 0.234355541955933 1177 16648368 SGTC_575 k072-0246 11.9 µM 0.723210740735381 0.244371675659776 no 849 0.234775210506231 1155 6796779 SGTC_1892 st058411 7.36 µM 0.72224172072813 0.244663719507629 no 850 0.235072938442753 1147 3934738 SGTC_1288 0973-0013 65.5 µM 0.721962764867762 0.244747826222506 no 851 0.23515868528013 1174 4315430 SGTC_3202 9113761 49.47 µM 0.720774270695025 0.245106338069684 no 852 0.235524204021221 1176 4798415 SGTC_468 gf-109203x 121 µM 0.720637530633455 0.24514760411614 no 853 0.235566278221445 1069 2396 A protein kinase C inhibitor. SGTC_601 0986-0029 62.9 µM 0.719418480063862 0.245515659892951 no 854 0.235941556897394 1149 24747981 SGTC_2000 st075254 36.4 µM 0.719089976972595 0.245614892307964 no 855 0.236042741276687 1115 17234175 SGTC_1441 4106-0040 13 µM 0.718177343448803 0.245890688661362 no 856 0.23632397292007 1166 2904180 SGTC_2475 5812728 15.03 µM 0.717911924280936 0.245970929084415 no 857 0.236405797505932 1182 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_144 4161-2749 112.381 µM 0.717899920730008 0.245974558280232 no 858 0.236409498381852 1064 797501 YMR168C CEP3 SGTC_3259 9138485 49.47 µM 0.717370272219717 0.2461347226737 no 859 0.23657282875745 1274 17646153 SGTC_1841 st054148 70 µM 0.716533982784698 0.246387728359743 no 860 0.2368308459043 1116 675442 SGTC_1219 1469-0211 33.1 µM 0.716456146506718 0.246411283540374 no 861 0.236854868298772 1139 6822282 SGTC_1275 0867-0008 21.1 µM 0.715790064191768 0.246612905847942 no 862 0.23706049421261 1153 3422836 SGTC_3060 1327-0027 12.5 µM 0.715274995629883 0.246768877039841 no 863 0.237219567986668 1107 16000455 YPR107C YTH1 SGTC_955 1216-0110 33 µM 0.714372605945517 0.247042262677125 no 864 0.237498403309402 1138 3619719 SGTC_1809 st050081 57.6 µM 0.713970420170721 0.247164160017633 no 865 0.237622735270813 1213 5036894 SGTC_346 4513-0042 7.16 µM 0.712537083429867 0.247598847443739 no 866 0.238066128203376 1156 2827372 SGTC_854 0422-0053 192 µM 0.712354596686195 0.247654219412046 no 867 0.238122611754294 1176 3596728 SGTC_2120 5538279 151.968 µM 0.71205981985473 0.247743677539869 no 868 0.238213866999981 1165 2058197 SGTC_3164 9100705 49.47 µM 0.711359865914463 0.247956166903419 no 869 0.238430631289499 1161 17174235 SGTC_3022 9087993 49.47 µM 0.7108247852688 0.248118670226739 no 870 0.238596409827338 1180 17173644 SGTC_3190 9110366 49.47 µM 0.710604780398949 0.248185501907528 no 871 0.238664589972535 1093 17123768 SGTC_3066 9117245 49.47 µM 0.709888512959775 0.248403151567443 no 872 0.238886637161516 1209 17176980 SGTC_1259 0671-0132 43 µM 0.709716301590534 0.248455495994646 no 873 0.23894004055812 1120 X1259 SGTC_757 1066-0008 322 µM 0.708077560290958 0.248953892817412 no 874 0.239448546910431 1161 6842497 SGTC_1882 5615643 20 µM 0.707784206188461 0.249043167865813 no 875 0.239539637893187 1129 2253075 SGTC_2345 9052315 157.45 µM 0.705224710130037 0.249822809116755 no 876 0.240335203026242 1169 6469265 SGTC_2675 theaflavin digallate 100 µM 0.704625435267955 0.250005539659962 no 877 0.24052168268062 1161 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3302 9125395 16.351 µM 0.704159151250647 0.25014776775627 no 878 0.240666833326253 1154 17599668 SGTC_1349 flufenamic acid 69 µM 0.702272456999458 0.250723693790209 no 879 0.24125463327185 1158 3371 A non-steroidal anti-inflammatory. SGTC_3252 9135871 49.47 µM 0.701994004505821 0.250808752700641 no 880 0.241341451221519 1223 17682838 SGTC_2126 5251174 33.877 µM 0.701835443676325 0.250857195118604 no 881 0.241390896057737 1221 790722 SGTC_624 k048-0052 28 µM 0.699496652359805 0.251572301555693 no 882 0.242120852189492 1149 6835531 SGTC_277 nystatin 15.5 µM 0.698408154500863 0.251905486424638 no 883 0.242460989069247 1193 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_510 ag-490 170 µM 0.696813319040069 0.25239407952084 no 884 0.242959814847437 1289 5328779 SGTC_734 2023-0417 80 µM 0.696729982176854 0.252419624291257 no 885 0.242985895847622 1156 3935732 SGTC_2333 9017922 200 µM 0.696254473428551 0.252565405323569 no 886 0.243134739438684 1205 3163164 SGTC_218 alverine citrate 93.75 µM 0.695653355644834 0.252749758916492 no 887 0.243322971661508 1181 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2484 5809818 12.04 µM 0.695218204158705 0.252883257392842 no 888 0.243459282821728 1188 2870548 SGTC_1251 0490-5699 265 µM 0.695211456598805 0.252885327743361 no 889 0.243461396818963 1241 3883818 SGTC_1125 tnp00248 1.32998 µM 0.694790088857411 0.253014633474542 no 890 0.243593430146668 1290 24207736 SGTC_1289 0976-0073 69.1 µM 0.694346875139798 0.253150680642935 no 891 0.243732350512423 1222 3391136 SGTC_988 1497-1057 103 µM 0.692006676754613 0.253869656304612 no 892 0.244466568016387 1200 3533044 SGTC_559 1550-0661 158 µM 0.690382510276382 0.254369275884027 no 893 0.24497683620781 1210 5830875 SGTC_368 fentichlor 4.58 µM 0.690024743985523 0.254479399739624 no 894 0.245089313448358 1174 7329 A pesticide. SGTC_1147 3809-1045 12.3 µM 0.689928482002044 0.254509034355015 no 895 0.245119581751754 1156 325925 SGTC_775 4577-0580 57.3 µM 0.688171195031536 0.255050339407743 no 896 0.245672490493489 1265 2006902 SGTC_2505 galangin 7.89 µM 0.687448610557369 0.255273094981265 no 897 0.24590003698062 1132 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_974 1326-0144 138 µM 0.687309671045435 0.255315938377266 no 898 0.245943802885955 1232 5411856 SGTC_2926 9010726 65.15 µM 0.686401898041484 0.255595951790245 no 899 0.246229853957289 1210 2994293 SGTC_1139 k015-0024 46.9 µM 0.685500724064995 0.255874088226856 no 900 0.246514001943297 1200 2766652 SGTC_2034 5197015 53.07 µM 0.684708005066189 0.256118881870173 no 901 0.246764098298519 1203 780676 SGTC_1026 k007-1105 30.6 µM 0.684666818686465 0.256131603665882 no 902 0.246777095975571 1214 7066794 SGTC_2488 5268135 45.7 µM 0.684524081035158 0.256175695530105 no 903 0.24682214423471 1210 1270356 YLR208W SEC13 SGTC_1485 3909-9022 254 µM 0.682632818017007 0.256760282801356 no 904 0.247419445601197 1235 714516 SGTC_2032 5185112 25.99 µM 0.681604621877565 0.257078388214869 no 905 0.247744495821411 1151 5718189 SGTC_3209 9113616 49.47 µM 0.680636365154858 0.257378136735131 no 906 0.248050805356738 1241 16649353 SGTC_1497 4476-2978 41.3 µM 0.68062470867365 0.257381746401684 no 907 0.248054494133326 1247 1528379 SGTC_1361 1608-0041 5.61 µM 0.680216240709992 0.257508253426935 no 908 0.248183775212041 1213 X1361 SGTC_2712 st079126 47.7 µM 0.679008907623936 0.257882366510727 no 909 0.248566108975549 1197 3152970 SGTC_2223 6903751 107.57 µM 0.678285256300509 0.258106737517347 no 910 0.248795422507661 1191 5598863 SGTC_1374 2889-5571 141 µM 0.674205632459323 0.259373532624206 no 911 0.250090294610916 1227 2853281 SGTC_106 0092-0003 11.579 µM 0.673250055295309 0.259670719802996 no 912 0.250394110642926 1194 1072148 SGTC_1727 st034309 9.9045 µM 0.673108475169254 0.259714766564803 no 913 0.250439141236838 1260 870305 SGTC_2301 7769476 200 µM 0.672575965938579 0.259880469162342 no 914 0.250608548111782 1232 977820 SGTC_163 TUB2.036 7.546 µM 0.671781619206893 0.260127749887463 no 915 0.250861365980628 1255 15992207 YJR013W GPI14 SGTC_2753 fluvastatin 17.09 µM 0.66776708912553 0.261379328946065 no 916 0.252141138769602 1243 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1012 4112-3522 18 µM 0.667179668250592 0.261562723660449 no 917 0.25232868824121 1235 3112398 SGTC_1875 nocodazole 6 µM 0.667047762385281 0.261603914181609 no 918 0.252370812746233 1235 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3291 9121177 71.43 µM 0.666952916308281 0.261633534022447 no 919 0.252401104395589 1196 17015612 SGTC_2532 xanthone 78.9 µM 0.666371064979029 0.261815280238182 no 920 0.252586976220197 1167 7020 An insecticide. SGTC_1258 0671-0043 57.1 µM 0.665437899523236 0.262106897566358 no 921 0.252885225480063 1228 4298767 SGTC_2163 5671233 125 µM 0.662664555595751 0.262974558272986 no 922 0.253772707566076 1304 701023 SGTC_2423 st077119 87.2 µM 0.662414672596016 0.263052808019538 no 923 0.253852751439526 1211 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2520 obtusaquinone 4.71 µM 0.661250569161711 0.26341749858968 no 924 0.254225817948304 1303 5967872 SGTC_2491 paeonol 100 µM 0.660135121572901 0.263767188238207 no 925 0.254583560982791 1196 11092 Increases levels of cortical cytochrome oxidase. SGTC_585 0kpi-0023 191 µM 0.660127061019124 0.263769716060181 no 926 0.254586147098952 1211 64601 SGTC_657 3534-0529 86.7 µM 0.658340487778964 0.264330297247616 no 927 0.255159683542279 1294 1049549 SGTC_124 0136-0217 7.121 µM 0.658220278098913 0.26436803775129 no 928 0.255198298221192 1367 3976905 SGTC_2982 9019404 25.97 µM 0.657524440753539 0.26458655367242 no 929 0.255421880474154 1139 22333232 SGTC_1140 3229-1848 2.98 µM 0.657114363890898 0.264715374375697 no 930 0.255553691816611 1258 2849525 SGTC_161 4065-0411 162.148 µM 0.656779850774552 0.26482048125412 no 931 0.255661240950634 1262 1906281 YLR208W SEC13 SGTC_286 k060-0067 22.9 µM 0.654728389548171 0.265465531571655 no 932 0.256321321746406 1223 5985051 SGTC_1466 k213-0079 57.5 µM 0.65372235479685 0.265782154749351 no 933 0.256645349093874 1237 3657981 SGTC_2438 5259590 200 µM 0.653442452134118 0.265870280832047 no 934 0.256735539079383 1263 1201127 SGTC_2747 doxorubicin 7.63 µM 0.65342659084434 0.26587527513042 no 935 0.256740650383934 1156 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1870 st057514 26.5 µM 0.65309557450292 0.265979514221998 no 936 0.256847332569595 1262 5393161 SGTC_1628 st004252 77.7 µM 0.651007364667396 0.266637581319944 no 937 0.257520866411734 1266 692968 SGTC_2732 terfenadine 20 µM 0.650995190333331 0.266641420285564 no 938 0.25752479582495 1265 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2939 9044578 71.43 µM 0.648436052923077 0.267449019822747 no 939 0.258351479104223 1248 2653634 SGTC_1400 3771-8998 51.5 µM 0.647258112975263 0.267821162263621 no 940 0.258732453014809 1226 670767 SGTC_2757 clomiphene 4.22 µM 0.645884622867351 0.268255413347512 no 941 0.259177039435164 1326 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2336 9001819 198.65 µM 0.643572368449629 0.268987269199399 no 942 0.259926386454241 1352 2989602 SGTC_72 0744-0168 198.391 µM 0.641813896548701 0.269544516500467 no 943 0.260497012813088 1234 677577 SGTC_1831 st055328 12 µM 0.639368581428561 0.270320379912632 no 944 0.261291591506865 1299 1103068 SGTC_3106 9121286 49.47 µM 0.638841242384196 0.270487843252471 no 945 0.261463107686723 1305 15943471 SGTC_622 1348-1566 26.3 µM 0.638684317423013 0.270537686811232 no 946 0.261514158437875 1316 7340407 SGTC_1481 3346-2004 36 µM 0.638361052537612 0.270640378832578 no 947 0.261619338937714 1279 2770522 SGTC_2546 rhodinyl acetate 100 µM 0.637683100145054 0.270855808151378 no 948 0.261839994388451 1279 6708682 SGTC_3063 1327-0034 4 µM 0.636621384303612 0.271193355812168 no 949 0.262185746316082 1203 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_386 1509-0011 3.07 µM 0.635359268803161 0.271594888501884 no 950 0.262597063288711 1311 3107280 SGTC_3121 9125696 49.47 µM 0.635230440235434 0.271635891000492 no 951 0.262639066424557 1337 1235365 SGTC_2980 9014342 25.29 µM 0.634770441627758 0.271782320723985 no 952 0.262789071952179 1289 2996599 SGTC_860 0443-0016 25.1 µM 0.634623679479336 0.271829047262107 no 953 0.262836940301741 1293 5337942 SGTC_1871 st057448 67.3 µM 0.634301353785174 0.271931684234931 no 954 0.262942086592794 1383 691747 SGTC_212 3807-4682 38.772 µM 0.632835177500428 0.272398796434976 no 955 0.263420641122264 1369 3125501 YBL034C STU1 SGTC_1700 st030840 7.9285 µM 0.632642989759854 0.272460055465092 no 956 0.263483403436506 1318 5499307 SGTC_319 1348-1596 45.5 µM 0.631716056480654 0.272755607566725 no 957 0.263786217074022 1358 5380505 SGTC_1928 4'-methoxychalcone 40.3 µM 0.63166034414454 0.272773376476816 no 958 0.263804423016893 1347 641818 SGTC_2761 levamisole 97.89 µM 0.62868575990614 0.273722924364722 no 959 0.264777401300757 1350 26879 An alkaline phosphatase inhibitor. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.628243460838486 0.273864254745028 no 960 0.264922231766346 1285 688664 SGTC_2448 5185112 27.17 µM 0.627978440259745 0.273948955586413 no 961 0.265009031821799 1282 5718189 SGTC_2156 5649887 115 µM 0.627741817103381 0.274024591523394 no 962 0.265086543306332 1341 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1609 st001574 46.4 µM 0.627375178891508 0.274141806792071 no 963 0.265206667024008 1278 3960012 SGTC_1511 0906-3109 28.5 µM 0.625942945881325 0.274599932939384 no 964 0.265676182225208 1334 2882180 SGTC_2385 9074692 200 µM 0.625556351915489 0.274723656844174 no 965 0.26580298781313 1272 17046906 SGTC_1793 st048256 72.231 µM 0.623138934680228 0.275497939628907 no 966 0.266596613021019 1242 672022 SGTC_2165 5727197 32.143 µM 0.622471404333939 0.275711934159069 no 967 0.266815970597517 1426 1361712 SGTC_21 0849-0113 22.993 µM 0.618598770563526 0.276955018988951 no 968 0.268090355995441 1285 1560156 SGTC_2831 7999036 19.48 µM 0.618360439669944 0.277031610862254 no 969 0.268168884601878 1377 2988270 SGTC_2876 9059903 25.97 µM 0.618059227996597 0.277128425422283 no 970 0.268268148606731 1300 6916095 SGTC_78 0336-0123 156.75 µM 0.617933188284451 0.277168941644241 no 971 0.268309690352459 1256 6765896 SGTC_878 0828-0289 13.7 µM 0.617524867867412 0.277300218591933 no 972 0.268444291923425 1325 745350 YLR208W SEC13 SGTC_2243 6634756 200 µM 0.617335889744025 0.277360986245194 no 973 0.268506599472326 1381 885676 SGTC_393 acivicin 6.25 µM 0.616161603703241 0.277738734589324 no 974 0.268893933538183 1278 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2266 7929956 200 µM 0.613979733837552 0.278441272344283 no 975 0.26961435968275 1313 2967153 SGTC_457 grayanotoxin iii 135 µM 0.613010686588856 0.278753572195428 no 976 0.269934636804624 1281 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_125 0133-0007 11.75 µM 0.612818122981056 0.278815650962729 no 977 0.269998303141621 1389 26541 SGTC_278 4092-0821 23.9 µM 0.612300602638303 0.278982522802023 no 978 0.270169445515758 1338 877900 SGTC_2177 5811945 192 µM 0.612214915690224 0.279010156815557 no 979 0.270197787158582 1373 5343475 SGTC_941 3237-0776 460 µM 0.611234980718338 0.279326280167509 no 980 0.270522014178722 1374 760008 SGTC_483 fpl-64176 144 µM 0.610224519380488 0.279652433342551 no 981 0.270856544760929 1343 3423 SGTC_961 1252-1571 372 µM 0.609346865616987 0.279935869262917 no 982 0.271147274562908 1381 6813498 SGTC_1463 k081-0032 34.1 µM 0.607890624405107 0.280406465532889 no 983 0.271630009107433 1219 977755 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.607333311133891 0.280586667167476 no 984 0.271814868004342 1449 16725076 SGTC_2035 5154463 94.595 µM 0.607290012079434 0.280600669826296 no 985 0.271829232772276 1343 2769623 SGTC_460 trequinsin 123 µM 0.606411906953128 0.280884716779403 no 986 0.272120631848396 1366 5537 A vasodilator. SGTC_1990 st072050 59.8 µM 0.604256864673137 0.281582412306626 no 987 0.272836439942972 1319 17233948 SGTC_1996 st072960 66.8 µM 0.603839192217882 0.281717730511251 no 988 0.272975279913306 1316 1719405 SGTC_1563 conessine 56.1 µM 0.602599208800531 0.282119646951133 no 989 0.273387673421098 1398 441082 An anti-amoebic, histamine inhibitor. SGTC_3038 9091290 49.47 µM 0.6016137651867 0.282439256025672 no 990 0.273715631974664 1375 25236843 SGTC_2978 9011784 42.97 µM 0.600371028128296 0.282842561226036 no 991 0.274129495812872 1414 2994934 SGTC_1612 st002233 45.4 µM 0.600038065944268 0.282950664338073 no 992 0.274240433385768 1342 1035021 SGTC_875 0709-0210 25.7 µM 0.599574883874147 0.283101079033993 no 993 0.274394794966039 1361 6251364 SGTC_618 k072-0232 33.2 µM 0.598431286286992 0.283472617499659 no 994 0.274776097622795 1348 5872756 YGL099W LSG1 SGTC_2642 cholecalciferol 100 µM 0.598120544147665 0.283573613531546 no 995 0.274879751564081 1355 9821465 A vitamin D precursor, similar to steriods. SGTC_3310 9130229 44.1445 µM 0.598020030205292 0.283606285817218 no 996 0.274913284022584 1385 7761258 SGTC_869 0564-0080 44.1 µM 0.596405230930862 0.284131427060211 no 997 0.275452273405783 1324 6843321 SGTC_435 c-PAF 6.7 µM 0.596399512012992 0.284133287708576 no 998 0.275454183195569 1312 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_478 N-arachidonylglycine 10 µM 0.594941019578746 0.284607997961378 no 999 0.27594144836896 1297 5283389 SGTC_1752 st044819 83.042 µM 0.594350981413709 0.284800151171994 no 1000 0.276138693395571 1284 441209 YML126C ERG13 SGTC_739 1486-1183 203 µM 0.594245026231123 0.28483466334022 no 1001 0.276174120691935 1354 4346692 SGTC_514 4466-0038 2.65 nM 0.592005944072354 0.285564452840464 no 1002 0.276923304022854 1305 5722064 SGTC_3100 9120536 49.47 µM 0.591756958920012 0.28564566012983 no 1003 0.277006674387342 1278 16421196 SGTC_141 0443-0274 32.331 µM 0.590467640806354 0.286066350962259 no 1004 0.277438587011868 1415 1627241 SGTC_2720 fluspirilene 36.88 µM 0.588456067919839 0.286723293217476 no 1005 0.278113106753352 1352 3396 An atypical antipsychotic. SGTC_408 cantharidin 100 µM 0.586425275007334 0.287387237032915 no 1006 0.278794881742914 1355 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1636 st007707 68.9 µM 0.585834196640371 0.287580619694996 no 1007 0.27899347047889 1406 403051 SGTC_1758 st042942 75.2445 µM 0.582759939488385 0.288587412763607 no 1008 0.280027458272558 1325 669317 SGTC_1442 4112-3290 3 µM 0.582563128701089 0.288651923136843 no 1009 0.280093716326783 1334 704353 SGTC_2285 7945142 200 µM 0.579294732144693 0.289724225388352 no 1010 0.281195159698436 1369 2970608 SGTC_2715 st079500 56.4 µM 0.578643191509355 0.289938207435034 no 1011 0.281414977426082 1325 28246688 SGTC_1408 3909-7976 48.8 µM 0.578065007689336 0.290128159331624 no 1012 0.281610115342273 1391 24152374 SGTC_3221 9128209 49.47 µM 0.577962576580243 0.290161817310536 no 1013 0.281644692800062 1391 16460723 SGTC_1704 st028805 70.8 µM 0.577807391483787 0.290212813280039 no 1014 0.281697082212274 1367 2876101 SGTC_928 2764-0428 58.7 µM 0.577485687252923 0.290318543112835 no 1015 0.281805702292092 1430 662578 SGTC_3150 9097574 49.47 µM 0.57681205232595 0.290539995283976 no 1016 0.282033213467083 1390 17217476 SGTC_205 1486-1330 71.903 µM 0.576393409718144 0.290677660556293 no 1017 0.282174648955163 1388 4118834 SGTC_491 tetrandrine 80.3 µM 0.575865775260368 0.29085120985137 no 1018 0.282352955197489 1427 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1114 scopoletin 1.73284 µM 0.575308820162407 0.291034455809588 no 1019 0.282541228701109 1410 5280460 A coumarin with genotoxic properties. SGTC_16 erodoxin 22.806 µM 0.57255871241838 0.291940069103439 no 1020 0.283471760864289 1399 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_539 4859-0462 2.54 µM 0.572213628024448 0.292053798349828 no 1021 0.283588627977728 1396 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_527 4476-4215 268 µM 0.568250454935371 0.293361414851706 no 1022 0.284932457948311 1407 4418754 SGTC_1185 1319-0113 81.3 µM 0.566785898656954 0.293845318759953 no 1023 0.2854298261298 1421 4672763 SGTC_1842 st055362 61.2 µM 0.566661441228317 0.293886457744236 no 1024 0.28547211133754 1425 676032 SGTC_1195 1502-0147 41.1 µM 0.566638745846104 0.293893959913633 no 1025 0.285479822560382 1372 817940 SGTC_63 0099-0242 26.702 µM 0.566438166894199 0.293960266999536 no 1026 0.285547977695035 1382 3898502 YLR359W ADE13 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.565515538181462 0.29426535725351 no 1027 0.285861579309324 1448 6710655 SGTC_2033 5192550 145 µM 0.56541103299137 0.294299923727118 no 1028 0.285897110958981 1358 182073 SGTC_43 0570-0105 72.5 µM 0.565093511898988 0.294404959530173 no 1029 0.286005080660579 1430 1114046 YDL195W SEC31 SGTC_1176 0848-0131 83.3 µM 0.564510577049769 0.294597839097641 no 1030 0.28620335194408 1444 6769040 SGTC_1426 4048-4480 71.7 µM 0.563795193461749 0.294834622509383 no 1031 0.28644676166039 1433 14224343 SGTC_3020 9089140 49.47 µM 0.563595152826519 0.294900849259342 no 1032 0.286514843183993 1403 17217859 SGTC_367 0335-0881 7.1 µM 0.562175029546404 0.295371201451892 no 1033 0.286998386336052 1446 23828853 SGTC_1949 st076024 69.1 µM 0.561134469159669 0.295716059399124 no 1034 0.287352935877918 1369 2921930 SGTC_1738 st035555 74 µM 0.556516615406071 0.297248715883842 no 1035 0.28892886954959 1402 5331140 SGTC_1161 k007-0610 110 µM 0.55627619061086 0.297328611727672 no 1036 0.289011030515772 1452 5843850 SGTC_2619 obliquin 87.91 µM 0.556047235375946 0.297404705227698 no 1037 0.289089282175791 1410 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1351 1496-0003 46.5 µM 0.553888362382319 0.298122645748518 no 1038 0.28982762504255 1405 3891978 SGTC_2132 5317594 122.667 µM 0.553441457305089 0.29827136412837 no 1039 0.289980578742624 1445 794577 SGTC_1510 1123-0200 71.5 µM 0.552498039587253 0.298585419861495 no 1040 0.290303588593623 1514 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1141 3253-0389 52.6 µM 0.551506385767304 0.298915695010668 no 1041 0.290643295189402 1391 5402031 SGTC_2320 7373003 200 µM 0.551263354080215 0.298996663214043 no 1042 0.290726577874207 1355 5415828 SGTC_991 3996-0057 64.7 µM 0.550231473722692 0.299340554348547 no 1043 0.291080309351159 1420 715343 SGTC_998 3996-0085 177 µM 0.548605762054141 0.299882713190158 no 1044 0.291638015344485 1498 715391 SGTC_2697 mebhydrolin 72.4 µM 0.548426885482263 0.299942393901095 no 1045 0.291699409976972 1499 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1672 st016598 6.51 µM 0.547814545768385 0.300146736741416 no 1046 0.291909624913163 1366 4665860 YNL267W PIK1 SGTC_1779 st039427 55 µM 0.547298049106527 0.300319144890667 no 1047 0.292086991966876 1561 1124498 SGTC_2111 5486399 200 µM 0.545779811472414 0.30082619615876 no 1048 0.292608651160141 1410 689674 SGTC_2780 5215298 71.43 µM 0.545415770461445 0.300947833618071 no 1049 0.292733798219035 1452 2834131 SGTC_1270 0831-1170 17.3 µM 0.545371924597536 0.300962485385368 no 1050 0.292748872870662 1378 6764716 SGTC_2202 7226349 200 µM 0.545124065433068 0.301045317370435 no 1051 0.292834096137083 1390 844334 SGTC_1146 3579-1023 7 µM 0.544744967630105 0.301172027832533 no 1052 0.292964466438806 1527 X1146 SGTC_207 4185-0010 4.486 µM 0.544587040199326 0.301224820924283 no 1053 0.293018785031043 1469 3761753 SGTC_807 1315-0151 48 µM 0.543589849045569 0.301558265205177 no 1054 0.293361873314551 1482 4011080 SGTC_1786 berberine 21.6 µM 0.5434624335877 0.301600882795385 no 1055 0.293405724607421 1381 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_505 gw-5074 63.9 µM 0.542811780641988 0.301818553724113 no 1056 0.293629700603633 1477 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2087 5276107 200 µM 0.539927689114979 0.302784253262432 no 1057 0.29462345079735 1410 144405 SGTC_607 4491-0986 66.8 µM 0.539872127563643 0.30280287088533 no 1058 0.294642610455883 1498 698981 YDR232W HEM1 SGTC_1699 st031318 29.054 µM 0.539472403462061 0.302936825964084 no 1059 0.294780466908875 1475 5340658 SGTC_905 2-aminofluorene 215 µM 0.53837228736036 0.303305632475617 no 1060 0.295160027325228 1437 1539 An established DNA mutagen. YPR165W RHO1 SGTC_694 1315-0438 43.2 µM 0.535828639948237 0.304159140579778 no 1061 0.296038493268474 1460 6793154 SGTC_2729 fluphenazine 10.66 µM 0.535090018813453 0.304407181527515 no 1062 0.296293805752001 1362 3372 An atypical antipsychotic. SGTC_1143 3454-2408 5.08 µM 0.532699832746012 0.305210461119489 no 1063 0.29712069097243 1403 X1143 SGTC_2739 tacrine 100.86 µM 0.532246887371713 0.305362790284394 no 1064 0.297277506330934 1422 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_833 3852-0053 558 µM 0.532089542773967 0.305415714425868 no 1065 0.297331989849903 1506 3123681 SGTC_1028 k015-0029 4.8 µM 0.531794410813732 0.305514995441129 no 1066 0.297434197130096 1432 4588309 SGTC_1006 4099-6547 255 µM 0.531518585270232 0.305607794798324 no 1067 0.297529732899459 1466 3146833 SGTC_842 0271-0008 11.1 µM 0.531360696088095 0.305660921005351 no 1068 0.297584426178273 1495 1221709 SGTC_442 cape 100 µM 0.531261111209185 0.305694431211832 no 1069 0.297618925034244 1524 5281787 SGTC_1103 duloxetine 36.1 µM 0.530179997349891 0.306058329561779 no 1070 0.297993569100387 1553 60835 A selective serotonin reuptake inhibitor. SGTC_3148 9097893 49.47 µM 0.530086469504396 0.306089819642811 no 1071 0.298025989895736 1330 17174100 SGTC_1722 st034304 3.6505 µM 0.52894506387717 0.306474237230332 no 1072 0.298421779885754 1422 4036148 YLR033W RSC58 SGTC_2497 7-hydroxyflavone 100 µM 0.525134682863877 0.307759088477757 no 1073 0.299744783614384 1476 5281894 SGTC_3131 9127911 49.47 µM 0.524769618097607 0.307882311617162 no 1074 0.29987167720452 1485 45595681 SGTC_2344 7990960 76.95 µM 0.521620013290918 0.308946320844051 no 1075 0.300967463020216 1462 140813 SGTC_828 2074-0507 139 µM 0.521324963241792 0.309046077925396 no 1076 0.301070206940963 1529 X828 SGTC_411 enrofloxacin 100 µM 0.519208307774197 0.309762136441757 no 1077 0.301807743130038 1592 71188 A bacterial gyrase inhibitor. SGTC_3322 9139058 2.11 µM 0.517130867070107 0.310465631376129 no 1078 0.302532403767463 1513 4908926 YPR165W RHO1 SGTC_519 k048-0011 62.8 µM 0.516934278012538 0.310532239362974 no 1079 0.302601019076449 1483 6836379 SGTC_3338 9144300 39.5675 µM 0.516624772241464 0.310637118197612 no 1080 0.302709059739227 1480 4901274 SGTC_3007 9078383 71.4286 µM 0.5153101095358 0.31108277502574 no 1081 0.303168167808801 1459 6496995 SGTC_3320 9137005 35.139 µM 0.5152173923487 0.311114215646272 no 1082 0.303200558366815 1454 4908713 SGTC_1796 st049173 110.4 µM 0.514405989771305 0.311389423001297 no 1083 0.303484086182956 1435 94134 SGTC_1705 st027868 56.3335 µM 0.514223149999348 0.311451452216771 no 1084 0.303547992098595 1525 292948 SGTC_649 1123-0311 367 µM 0.508509363022189 0.313392570030292 no 1085 0.305548087260351 1445 693629 YIL048W NEO1 SGTC_1622 st003707 19.4 µM 0.504552607519868 0.314739819743838 no 1086 0.306936551862937 1498 10140899 SGTC_2811 7967822 32.47 µM 0.503624649746927 0.315056141568692 no 1087 0.307262583686772 1544 2232244 SGTC_1811 st050069 61.5 µM 0.503523496570484 0.315090630822819 no 1088 0.307298132401771 1487 3877702 SGTC_2561 acetosyringone 100 µM 0.503181001365817 0.315207420183392 no 1089 0.307418510472143 1432 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1943 st076331 65.2 µM 0.502209668902506 0.315538740734206 no 1090 0.307760021147876 1509 24208415 SGTC_331 k048-0133 24.5 µM 0.495755995696991 0.31774383898346 no 1091 0.310033287429683 1461 6813582 SGTC_2476 5806916 10.51 µM 0.494331309698152 0.31823150319461 no 1092 0.310536108313374 1523 2870194 SGTC_2785 7756463 72.73 µM 0.494117992917689 0.31830454781171 no 1093 0.310611425681113 1437 2201551 SGTC_753 1322-0200 289 µM 0.493472236124719 0.318525712984276 no 1094 0.310839476295563 1481 5403907 SGTC_2080 5212524 12.4 µM 0.492956159519085 0.318702510508079 no 1095 0.311021782287724 1563 260183 SGTC_1891 st059073 26.2 µM 0.490915337854511 0.319402059229633 no 1096 0.311743164223273 1627 688754 SGTC_2176 5809774 33.9695 µM 0.48996460110442 0.319728170661195 no 1097 0.312079474093169 1529 2870539 SGTC_2819 7996655 46.38 µM 0.489808073254819 0.31978187452269 no 1098 0.31213485866683 1535 6456960 SGTC_566 0958-0068 16.5 µM 0.489019628547816 0.320052443079092 no 1099 0.31241390023708 1511 6815365 SGTC_3067 9117431 49.47 µM 0.488304153367695 0.320298053732488 no 1100 0.312667210009899 1499 17150885 SGTC_1931 st074438 57.1 µM 0.487917026292655 0.320430980815333 no 1101 0.312804306980012 1456 2787313 SGTC_1835 st008666 49.2 µM 0.486733837614951 0.320837392808699 no 1102 0.313223481239043 1438 690455 SGTC_1102 cgs 12066b 26.1 µM 0.486568991282564 0.320894032727134 no 1103 0.313281901361168 1492 6438352 A 5-HT1B full agonist. SGTC_511 blebbistatin 171 µM 0.486220915832937 0.321013642438817 no 1104 0.313405271698337 1566 3476986 A myosin inhibitor. SGTC_720 r052-1644 49.9 µM 0.486139691113832 0.321041556489697 no 1105 0.313434063637165 1485 1422863 YOR257W CDC31 SGTC_2010 4012422 159 µM 0.486113781745918 0.321050460831924 no 1106 0.313443248037817 1552 952393 SGTC_2031 5180455 200 µM 0.485502513831611 0.321260566765045 no 1107 0.313659964966248 1470 29949 SGTC_2618 avocadyne 43.43 µM 0.484800231201075 0.321502027045824 no 1108 0.313909029355537 1533 3015189 SGTC_936 3005-4620 401 µM 0.484364094283914 0.321652018531497 no 1109 0.314063747919284 1606 777207 SGTC_1331 1472-0049 76.2 µM 0.482663859323588 0.322237022352476 no 1110 0.314667214234988 1461 24051409 SGTC_931 2812-0076 566 µM 0.481240204654187 0.322727201560207 no 1111 0.315172894749946 1503 3450959 SGTC_2363 9053361 176 µM 0.481232743097091 0.322729771465039 no 1112 0.315175546000175 1620 6469797 YMR079W SEC14 SGTC_2985 9022375 71.43 µM 0.481022560889132 0.322802165767748 no 1113 0.315250232127877 1512 4939335 SGTC_980 1473-0395 201 µM 0.48077693373608 0.322886777092909 no 1114 0.315337522828017 1468 768876 SGTC_735 3076-0345 636 µM 0.477390605758218 0.324054200299326 no 1115 0.316542001229495 1602 2888990 SGTC_2368 9071271 200 µM 0.4764989010981 0.324361900588999 no 1116 0.316859495023444 1475 27209959 SGTC_1447 4239-0816 81.9 µM 0.476415224803964 0.324390780905791 no 1117 0.316889295116415 1463 1341554 SGTC_3051 9093778 49.47 µM 0.476287462350177 0.324434879305293 no 1118 0.316934798144495 1512 17217378 SGTC_2408 sulbentine 18.36 µM 0.47557086145447 0.324682266389118 no 1119 0.317190069270992 1597 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_768 0384-0033 77.3 µM 0.474893102405506 0.324916315564435 no 1120 0.317431584027172 1481 3965305 YMR134W ERG29 SGTC_2273 7815444 169.05 µM 0.474490075763056 0.325055524727162 no 1121 0.317575236655102 1637 2824616 SGTC_3137 9097352 49.47 µM 0.474487942631651 0.325056261595651 no 1122 0.317575997049983 1591 44120435 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.473124543040182 0.325527373960642 no 1123 0.318062163856424 1489 16623 A steroid. SGTC_1850 st056238 17 µM 0.471670730310912 0.326030035134193 no 1124 0.318580916147303 1500 5393177 SGTC_2311 7694451 200 µM 0.471476468376212 0.326097225898398 no 1125 0.318650260038965 1585 2163142 SGTC_625 k213-0058 121 µM 0.470367833268363 0.326480785450533 no 1126 0.319046120784212 1593 3655420 SGTC_1885 st057546 99.9 µM 0.469506774687922 0.326778816477608 no 1127 0.319353721771625 1592 702008 SGTC_139 0099-0334 718.624 µM 0.467735224178629 0.327392336031602 no 1128 0.319986974109189 1539 97690 SGTC_1079 idarubicin 2.36 µM 0.467638854667356 0.327425723906578 no 1129 0.320021437091158 1531 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_316 k060-0003 58.6 µM 0.467598407429932 0.32743973753936 no 1130 0.320035902008438 1566 6152314 SGTC_1988 st071872 53.4 µM 0.467583468324814 0.3274449135077 no 1131 0.320041244665486 1562 16414116 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.467583322947339 0.327444963876958 no 1132 0.320041296656868 1528 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_168 3970-0862 530.542 µM 0.466966209627307 0.327658804803475 no 1133 0.320262026885459 1544 3135186 SGTC_321 4534-3890 65.3 µM 0.466017862348573 0.32798753447539 no 1134 0.320601357464152 1589 699746 SGTC_439 amiodarone 34.4 µM 0.465631445511393 0.328121518034067 no 1135 0.320739665291465 1595 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1317 1273-0028 910 nM 0.463763335220976 0.328769565621198 no 1136 0.321408657343375 1520 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_579 4491-1009 110 µM 0.46357300786692 0.328835619144142 no 1137 0.321476848363379 1680 1271041 SGTC_1245 0418-0076 17.2 µM 0.460586129883903 0.329872920875598 no 1138 0.322547782293334 1573 6790114 SGTC_3142 9086498 49.47 µM 0.460124455088889 0.330033371254137 no 1139 0.322713445805908 1530 25236367 SGTC_1184 1269-1718 139 µM 0.459327020000059 0.330310585346336 no 1140 0.322999673608705 1659 5403821 SGTC_873 0591-4978 488 µM 0.458918607544277 0.330452598739616 no 1141 0.323146307972488 1684 3305145 SGTC_3144 9087057 49.47 µM 0.458675317771205 0.330537207194269 no 1142 0.323233670579442 1669 17249618 SGTC_1913 st060213 96.1 µM 0.458425936909731 0.330623942925637 no 1143 0.323323230545958 1656 688959 SGTC_492 tmb-8 126 µM 0.456228196850312 0.331388719213058 no 1144 0.32411294556914 1538 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1766 st045414 44.774 µM 0.455946116317697 0.331486929475164 no 1145 0.32421436313645 1541 253960 SGTC_1662 st014054 52 µM 0.455123848834508 0.331773279439598 no 1146 0.324510070737486 1516 2838777 SGTC_752 1896-0090 130 µM 0.454684184050507 0.331926430544276 no 1147 0.324668230426143 1543 772567 SGTC_1218 1348-1416 30.7 µM 0.453269897766282 0.332419267856558 no 1148 0.325177202990407 1547 6787668 SGTC_2899 9053889 58.44 µM 0.453086485728232 0.332483202826416 no 1149 0.325243233138356 1578 6470052 SGTC_3087 9117406 49.47 µM 0.450826283935476 0.333271478381089 no 1150 0.326057378060864 1537 42546093 SGTC_349 k015-0014 24 µM 0.449471958336809 0.333744170889549 no 1151 0.326545616155874 1507 2196908 SGTC_788 1182-0090 188 µM 0.449396020058059 0.333770683014988 no 1152 0.326573000922601 1707 5715185 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.449309733586168 0.333800808984326 no 1153 0.326604118576002 1620 688751 SGTC_1482 3346-2049 8.48 µM 0.446458119778834 0.334797020227507 no 1154 0.327633179098839 1594 3826804 SGTC_2325 6158266 200 µM 0.446037696126455 0.334943993831308 no 1155 0.327785008231642 1544 3623240 SGTC_2299 7976368 114.88 µM 0.441791141611154 0.336429937646296 no 1156 0.329320174678654 1671 2979718 SGTC_2807 7945238 51.95 µM 0.441234560539587 0.336624885241449 no 1157 0.329521597744012 1605 17148797 SGTC_2037 5169046 200 µM 0.440867527201237 0.336753466046982 no 1158 0.329654451791022 1597 5718022 SGTC_3064 1327-0027 10 µM 0.440348770217664 0.336935231923338 no 1159 0.329842261491968 1510 16000455 YPR107C YTH1 SGTC_2965 9082772 38.63 µM 0.439674757183833 0.337171454439557 no 1160 0.330086343855596 1711 16459634 SGTC_2555 cholic acid 100 µM 0.439060084196198 0.337386935933364 no 1161 0.330309000302766 1598 6708657 Influences liver metabolism. SGTC_3155 9099265 49.47 µM 0.438459255829678 0.337597615574187 no 1162 0.33052669981867 1599 25236499 SGTC_398 bronopol 33.3 µM 0.436977671677474 0.338117348457241 no 1163 0.331063770567184 1607 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1162 k048-0130 20.1 µM 0.436386683246195 0.338324750649408 no 1164 0.331278099570981 1560 6797406 SGTC_2052 5265182 7.135 µM 0.434878799449996 0.338854151371232 no 1165 0.33182520194194 1670 1239884 SGTC_1007 4101-0031 70 µM 0.434653790951959 0.33893317660729 no 1166 0.331906872107937 1680 1146276 SGTC_2079 5212404 121 µM 0.433950291734912 0.339180298286723 no 1167 0.332162269078534 1675 758462 SGTC_2056 5235370 200 µM 0.432215533237662 0.339789971078822 no 1168 0.332792385405553 1535 5511916 SGTC_1495 4469-0029 237 µM 0.431744214770053 0.339955686268073 no 1169 0.332963664125544 1554 793680 SGTC_251 melphalan 456.522 µM 0.431696413005385 0.339972495057587 no 1170 0.332981037395378 1669 460612 A DNA alkylator. SGTC_2462 5162487 171.77 µM 0.430804087803502 0.340286326492754 no 1171 0.333305413510863 1608 2259986 SGTC_2175 5807670 165.306 µM 0.429367714506877 0.340791732401171 no 1172 0.333827822678685 1592 241186 SGTC_2773 thioridazine 9.09 µM 0.428639900874706 0.341047931931303 no 1173 0.334092651677693 1593 5452 An antipsychotic. SGTC_2211 7117706 200 µM 0.425855109119749 0.342028889555549 no 1174 0.335106713715097 1649 822771 SGTC_3136 9095672 49.47 µM 0.423677113366465 0.342796844268403 no 1175 0.335900654224965 1677 17217380 SGTC_126 0417-1624 672.48 µM 0.423065192311444 0.343012722891498 no 1176 0.336123848630769 1650 41912 YDL195W SEC31 SGTC_3049 9092223 49.47 µM 0.422384755247852 0.343252833349083 no 1177 0.336372101678944 1602 8623917 SGTC_1423 4048-0112 5.59 µM 0.416650856130991 0.345278698806054 no 1178 0.338466902586786 1680 X1423 SGTC_865 0488-0499 301 µM 0.416567328569748 0.345308243200378 no 1179 0.338497455393397 1617 9634651 SGTC_2870 9038528 12.99 µM 0.415645901823338 0.345634222038884 no 1180 0.338834566429487 1578 6463316 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.413130440019716 0.346524714845292 no 1181 0.339755524174491 1580 6708630 An antioxidant. SGTC_2705 st078069 42.8 µM 0.412368823885598 0.34679450044385 no 1182 0.340034555201948 1582 1530061 SGTC_2470 5664817 21.68 µM 0.411734130623555 0.347019385798455 no 1183 0.340267152837141 1620 2859561 SGTC_2129 girgensonine 121.053 µM 0.408461432713391 0.348179826285578 no 1184 0.341467469843695 1689 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_339 3091-4833 71.4 µM 0.407251035394046 0.348609372692007 no 1185 0.341911810721141 1652 3240077 SGTC_2162 5663267 200 µM 0.40701178755402 0.348694300085468 no 1186 0.341999665347378 1709 6456493 SGTC_705 1124-0212 310 µM 0.406977419580329 0.348706500536132 no 1187 0.342012286375185 1729 9554485 SGTC_45 0kpi-0036 14.9 µM 0.404021859848393 0.349756292869302 no 1188 0.343098322228727 1641 2795021 SGTC_2218 6965428 192.983 µM 0.403821928245872 0.349827348660784 no 1189 0.343171835087324 1677 675684 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.400871662732077 0.350876484805478 no 1190 0.344257307029203 1753 688664 SGTC_2045 5106652 78.05 µM 0.397324337641717 0.352139446112774 no 1191 0.345564151254894 1698 673349 SGTC_578 3460-0051 92 µM 0.393647513409428 0.353450236598852 no 1192 0.34692064851353 1742 2876744 SGTC_1861 st057647 17.4 µM 0.393079185198152 0.353653001666224 no 1193 0.347130498553809 1770 688668 SGTC_2293 7624732 200 µM 0.39176823756852 0.354120872773021 no 1194 0.347614732794333 1565 894453 SGTC_540 1187-0821 17.3 µM 0.391463707414334 0.354229589727245 no 1195 0.347727254938503 1590 847520 SGTC_1236 0330-0013 258 µM 0.390469688962164 0.354584535945998 no 1196 0.34809463236233 1636 4617066 SGTC_2814 7977482 42.97 µM 0.389607521980267 0.354892502665103 no 1197 0.348413394555893 1752 6456762 SGTC_47 0149-0135 24.25 µM 0.389502391039751 0.354930062010533 no 1198 0.348452271118295 1531 5239155 SGTC_2973 9094665 17.96 µM 0.389027918862046 0.355099590675297 no 1199 0.348627746851282 1755 25237061 YIL048W NEO1 SGTC_3017 9080681 49.47 µM 0.388847863107854 0.355163932014138 no 1200 0.348694345991815 1618 16451914 SGTC_2026 5148700 152 µM 0.388306329238179 0.355357469256749 no 1201 0.348894676989893 1636 79838 SGTC_3315 9136395 68.55 µM 0.38769604175916 0.355575622869304 no 1202 0.349120492675669 1772 16876844 SGTC_1687 st020778 55.3625 µM 0.387199785916818 0.355753049573294 no 1203 0.349304154309853 1665 4259299 SGTC_1635 st007035 42.4 µM 0.387074129788531 0.355797980458393 no 1204 0.349350664572468 1635 3716403 SGTC_2851 9015922 71.43 µM 0.382362067501475 0.357484314589558 no 1205 0.351096411208757 1743 2996893 SGTC_2261 9010538 184.68 µM 0.382253427295027 0.357523227301772 no 1206 0.351136697990698 1582 6457250 SGTC_2511 berberine 10.47 µM 0.378892052881668 0.35872793336088 no 1207 0.352384012940588 1647 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_470 aa-861 153 µM 0.377660224976653 0.359169769519446 no 1208 0.35284150953502 1627 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1470 k295-0292 231 µM 0.376415935594621 0.359616266706841 no 1209 0.353303850400414 1737 5045612 SGTC_2623 humulene 100 µM 0.375769700368083 0.359848235554205 no 1210 0.353544057655432 1617 6187145 An anti-inflammatory. SGTC_3125 9127534 49.47 µM 0.375207737422404 0.360049996488923 no 1211 0.353752988117923 1649 1639235 SGTC_1587 estradiol valerate 56.1 µM 0.37468847720175 0.36023646057529 no 1212 0.353946081431405 1794 13791 A steroid. SGTC_1888 azatryptophan 97.5 µM 0.372727431697921 0.360940963082426 no 1213 0.354675658889225 1637 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1680 diphenhydramine 100 µM 0.372474643901889 0.36103181109663 no 1214 0.354769743649754 1656 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_281 1672-3440 14.9 µM 0.371049564984006 0.361544108908336 no 1215 0.355300307513494 1719 6833000 SGTC_1611 st001856 99.4 µM 0.368267449338059 0.362544959079259 no 1216 0.356336910641563 1629 647478 SGTC_1631 benzylvanillin 81.9 µM 0.368256427435387 0.362548926019522 no 1217 0.356341019468144 1701 75506 SGTC_677 0929-0063 136 µM 0.36478723396963 0.363798269562504 no 1218 0.357635117617556 1649 1539583 SGTC_2799 7812892 81.82 µM 0.362961809667465 0.364456233494 no 1219 0.358316706555509 1786 20205235 SGTC_780 0109-0199 192 µM 0.362927839916332 0.364468481492802 no 1220 0.35832939469235 1810 610414 SGTC_2767 sibutramine 71.45 µM 0.362605156124185 0.364584833980305 no 1221 0.358449929017577 1805 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1167 k781-0610 148 µM 0.361821909390799 0.364867306937989 no 1222 0.358742559272102 1688 4525169 SGTC_1209 2323-2347 50.3 µM 0.361698785466394 0.364911717475523 no 1223 0.358788567376127 1765 5412760 SGTC_776 4476-4378 112 µM 0.359762375501852 0.365610414474883 no 1224 0.359512420901577 1671 2892008 SGTC_751 0833-0568 350 µM 0.359128249595752 0.36583931737509 no 1225 0.359749574614974 1715 6954252 SGTC_42 0133-0086 60.653 µM 0.359068423621166 0.365860915457616 no 1226 0.359771951434563 1579 162923 Model of phenazepam hydroxylation. SGTC_306 1672-3436 11.6 µM 0.359024855390475 0.365876644516018 no 1227 0.35978824764273 1734 6797378 SGTC_2402 5553605 200 µM 0.358353790631654 0.366118941638645 no 1228 0.360039284075342 1753 6758546 SGTC_500 h-89 112 µM 0.357413348732993 0.366458590898638 no 1229 0.3603911924983 1826 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2816 7982706 58.44 µM 0.356129652412658 0.366922378486278 no 1230 0.360871735828037 1676 2981853 SGTC_1340 1486-1359 257 µM 0.355697685911392 0.367078487708102 no 1231 0.361033489111361 1712 4309068 SGTC_74 000s-0487 160.283 µM 0.355592727794321 0.367116422048059 no 1232 0.361072795265298 1639 677548 SGTC_817 1391-0715 46 µM 0.351025254980017 0.368768466405502 no 1233 0.362784700874911 1659 1353946 SGTC_2398 5228213 48.84 µM 0.350658013081995 0.368901402810573 no 1234 0.362922464215453 1872 80771 YMR134W ERG29 SGTC_1615 st002656 86.5 µM 0.347904960076907 0.369898467839278 no 1235 0.363955780052339 1682 1584458 SGTC_2840 9008771 71.43 µM 0.347867206739511 0.369912146951567 no 1236 0.363969957081398 1857 2992978 SGTC_2074 5212007 75.395 µM 0.347205316321125 0.370151995476085 no 1237 0.364218538575365 1852 758611 SGTC_659 k018-0002 107 µM 0.346083884795138 0.370558482649605 no 1238 0.364639837020145 1828 6797879 YHR007C ERG11 SGTC_524 r073-0010 27.8 µM 0.345478973502257 0.370777805910273 no 1239 0.364867157511728 1671 2772106 SGTC_617 3770-0098 35 µM 0.343107952628804 0.37163787347683 no 1240 0.365758624275748 1728 5962639 SGTC_1659 st012954 42.1 µM 0.343104835152037 0.371639004737868 no 1241 0.365759796876813 1752 24207262 SGTC_2417 cerulenin 830 nM 0.34227940706069 0.371938572693958 no 1242 0.366070315738954 1708 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2751 anetholtrithion 17.25 µM 0.342266805174786 0.371943146826655 no 1243 0.36607505713921 1828 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2657 nystatin 74.44 µM 0.339611136907321 0.3729074825511 no 1244 0.367074695045407 1770 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_594 1487-1584 10.8 µM 0.339105769541092 0.373091083791805 no 1245 0.367265026109826 1653 5013332 SGTC_557 1315-0110 16.2 µM 0.337706201485037 0.373599700736087 no 1246 0.367792300472639 1670 6833801 SGTC_1942 st076330 65.2 µM 0.336924414455965 0.373883905845899 no 1247 0.368086940097182 1761 24208414 SGTC_1776 st049249 45.9 µM 0.334760652783377 0.374670861002243 no 1248 0.368902822060017 1666 1822314 SGTC_1610 st001799 48.1 µM 0.334394736216321 0.374803995734427 no 1249 0.369040855461219 1656 621897 SGTC_1646 st011709 75.6 µM 0.334064059172402 0.374924321788874 no 1250 0.369165610112475 1828 5757843 SGTC_1194 1488-0194 225 µM 0.330785942638017 0.376117812700113 no 1251 0.370403089932221 1734 1391452 SGTC_1688 st021091 57.6 µM 0.330148612609526 0.376349988729174 no 1252 0.37064383649187 1863 3656366 SGTC_3009 9080819 71.4286 µM 0.328849848160689 0.376823260320385 no 1253 0.371134591579557 1712 17027216 SGTC_3013 9080133 71.4286 µM 0.328465102516211 0.376963497756356 no 1254 0.37128001302479 1785 17050193 SGTC_3061 glucosamine 200 µM 0.327800158398738 0.377205904083839 no 1255 0.371531383775061 1858 91431 and experimental redox chemotherapeutic SGTC_385 1494-0393 12.4 µM 0.327380922964072 0.377358761841684 no 1256 0.371689896732089 1776 3090647 SGTC_3218 9131285 49.47 µM 0.326265603573415 0.377765512813211 no 1257 0.372111704966398 1861 17156417 SGTC_1183 1254-0324 198 µM 0.325063290495771 0.378204141757182 no 1258 0.37256658571428 1822 5799357 SGTC_3207 9114163 49.47 µM 0.324616579227258 0.378367151404023 no 1259 0.372735638908127 1904 849233 SGTC_1352 1496-0991 99 µM 0.323426805522805 0.378801417906721 no 1260 0.373186015808745 1706 3000039 SGTC_1252 0493-0875 34.8 µM 0.323353489318084 0.378828183277985 no 1261 0.373213774598315 1710 3960963 SGTC_3227 9130768 49.47 µM 0.322986893913178 0.378962024099353 no 1262 0.373352583860513 1793 17720899 SGTC_582 0987-0078 156 µM 0.322497795604016 0.379140612271534 no 1263 0.373537803740134 1775 1625765 SGTC_375 3970-0961 9.27 µM 0.321775949154175 0.379404232661699 no 1264 0.373811217925505 1769 2898222 SGTC_397 arbidol 50 µM 0.321704461924938 0.379430343056331 no 1265 0.373838298642059 1838 131410 A RNA synthesis inhibitor. SGTC_2248 tofa 1.1 µM 0.320697033996784 0.379798360084644 no 1266 0.374219997598037 1775 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_465 cgp-37157 41 µM 0.320180605676768 0.379987055438427 no 1267 0.374415712190462 1839 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1906 st060206 94.7 µM 0.320140292814473 0.380001786371489 no 1268 0.374430991211169 1862 5133468 SGTC_265 mycophenolic acid 32.932 µM 0.319952590954005 0.380070377778529 no 1269 0.374502134888628 1858 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1059 3448-6867 171 µM 0.316253639710832 0.381422843090093 no 1270 0.375904998367878 1912 3934407 SGTC_71 0417-1750 47.813 µM 0.315744252948361 0.381609206519271 no 1271 0.376098317308244 1909 6811472 SGTC_3174 9107204 49.47 µM 0.314689151097634 0.381995311664499 no 1272 0.376498841121127 1828 3938802 SGTC_2641 levomentholum 100 µM 0.31466762508263 0.382003190141669 no 1273 0.37650701392815 1813 16666 SGTC_2201 6605497 169.863 µM 0.313736540730753 0.3823440118234 no 1274 0.37686057273817 1842 670741 SGTC_995 3931-2021 34.6 µM 0.313646920653271 0.382376821898929 no 1275 0.376894609446177 1786 730143 SGTC_1355 1499-0035 1.68 µM 0.312389491276472 0.382837258055562 no 1276 0.377372267901052 1726 1548538 SGTC_2941 9056145 11.23 µM 0.31209589051108 0.382944790479222 no 1277 0.377483824783601 1828 2119517 SGTC_2589 lobaric acid 100 µM 0.311564377811859 0.383139482020703 no 1278 0.37768580495487 1693 73157 A novel microtubule depolymerizer. SGTC_1799 st045822 46.1415 µM 0.311208737006086 0.383269768692321 no 1279 0.377820970720253 1875 3674992 SGTC_2356 9061756 188.97 µM 0.311151809503317 0.383290624935051 no 1280 0.377842608123793 1890 20104043 SGTC_3021 9087658 49.47 µM 0.311098116563087 0.383310296457349 no 1281 0.377863016463396 1861 25237042 SGTC_2616 abietic acid 100 µM 0.309460382174096 0.383910458736031 no 1282 0.378485672249035 1944 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2287 7945887 168.79 µM 0.309221266412281 0.38399810816202 no 1283 0.378576608924073 1892 1245853 SGTC_1978 st071761 42 µM 0.309174639462576 0.384015200262893 no 1284 0.378594342122028 1721 5147680 SGTC_3267 9137951 49.47 µM 0.308973864723449 0.384088801093769 no 1285 0.378670703847669 1790 16643986 SGTC_1034 k072-0165 12.7 µM 0.308435199302633 0.384286287928865 no 1286 0.378875600732012 1909 5835461 SGTC_56 0957-0365 83.25 µM 0.306577823124233 0.384967473818196 no 1287 0.379582367925237 1857 6752360 SGTC_2158 5657123 3.6195 µM 0.304416051101512 0.385760742931585 no 1288 0.380405470350272 1836 2858827 SGTC_1579 chlormadinone acetate 49.4 µM 0.304327414939419 0.385793278476627 no 1289 0.380439230473335 1893 45114258 A steroidal progestin. SGTC_1054 3429-0080 167 µM 0.303399169593085 0.386134056349785 no 1290 0.380792839219003 1842 1162877 SGTC_1074 carmofur 3.8 µM 0.302861093858434 0.386331635216491 no 1291 0.380997861126331 1786 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_892 0929-0076 29 µM 0.301458619273663 0.386846755681557 no 1292 0.381532400086523 1762 5751038 SGTC_730 1436-0052 41.2 µM 0.300660412849976 0.387140021187962 no 1293 0.381836729364617 1796 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3025 9087895 49.47 µM 0.299470771126495 0.38757722174501 no 1294 0.382290435269465 1880 17173641 SGTC_2384 9036245 200 µM 0.299358835747669 0.387618366024666 no 1295 0.382333133547146 1862 6462766 SGTC_2516 gossypol 71.55 µM 0.297137151175208 0.388435254988558 no 1296 0.383180900984826 1893 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2430 5571206 200 µM 0.295131719990142 0.389173054066528 no 1297 0.383946629649606 1932 1731771 SGTC_2192 5915882 198.485 µM 0.294071851026788 0.3895631419998 no 1298 0.384351499993787 1809 2876149 SGTC_3135 9127742 49.47 µM 0.294045073298225 0.389572999065732 no 1299 0.384361730732578 1750 3643468 SGTC_1033 k072-0102 21.3 µM 0.293856963319533 0.389642245643809 no 1300 0.38443360258097 1904 5965931 SGTC_376 3970-0862 59.1 µM 0.291125844125219 0.390648012100607 no 1301 0.385477537405018 1900 3135186 SGTC_1096 rimcazole 32.2 µM 0.290922657331858 0.390722867344126 no 1302 0.385555236190645 1789 18528119 A dopamine reuptake inhibitor. SGTC_2581 avocatin a 64 µM 0.290319691738824 0.390945027345999 no 1303 0.385785837723449 1784 6710728 A skin care supplement. SGTC_551 k048-0028 34.9 µM 0.286911575309538 0.392201399937039 no 1304 0.387090013566123 1887 6836383 SGTC_3042 9091578 49.47 µM 0.286507699942814 0.392350359876188 no 1305 0.387244648424376 1865 25236497 SGTC_233 rapamycin 362 pM 0.286301307388859 0.39242648901187 no 1306 0.387323678434274 1898 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_181 1447-1644 8.07 µM 0.286222029847001 0.392455732104817 no 1307 0.387354035930475 1925 534600 SGTC_2886 9058944 51.95 µM 0.286067527312004 0.392512725172553 no 1308 0.387413201072581 1791 4949929 SGTC_1392 3455-1037 33.9 µM 0.285234780527908 0.392819949404082 no 1309 0.387732137808996 1890 981132 SGTC_2948 9070189 9.45 µM 0.28515873774094 0.392848007105081 no 1310 0.387761265492326 1934 6473636 YDL196W YDL196W SGTC_61 0978-8327 98.565 µM 0.284331595818487 0.393153235704989 no 1311 0.388078137467052 1933 6150059 YHR072W ERG7 SGTC_867 0518-0118 155 µM 0.283755009917933 0.39336604399515 no 1312 0.388299067373824 1956 6848158 SGTC_732 3970-1727 52.7 µM 0.283404940828899 0.393495264237328 no 1313 0.388433220676135 1939 1275699 SGTC_852 0418-0143 439 µM 0.283069235294815 0.393619193511488 no 1314 0.388561882086453 1908 5369229 SGTC_370 0180-0345 38.7 µM 0.282759421762328 0.393733574039875 no 1315 0.388680631061639 1767 3989527 SGTC_907 3448-6986 75.5 µM 0.281504420177411 0.394197003684292 no 1316 0.38916176914785 1897 590582 SGTC_3129 9127257 49.47 µM 0.27724556180684 0.395770769329638 no 1317 0.39079577848952 1696 837894 SGTC_3169 9102970 49.47 µM 0.276223424076019 0.396148731461294 no 1318 0.391188233522287 1862 17027839 SGTC_2802 7925815 54.55 µM 0.275009099165641 0.396597886708008 no 1319 0.391654623814359 1784 1262923 SGTC_2046 4110841 106 µM 0.274895033657422 0.396640084389013 no 1320 0.391698441392476 1946 44119630 YMR134W ERG29 SGTC_1107 amlodipine 47 µM 0.274798398806373 0.396675834676084 no 1321 0.391735564163693 1848 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2390 9097792 176.6 µM 0.273894836148994 0.397010151764844 no 1322 0.392082720029232 1748 4497149 SGTC_2090 5301565 104.445 µM 0.273810976953626 0.397041183408088 no 1323 0.392114943751769 1831 2056344 SGTC_1020 4335-0961 93.3 µM 0.272123793441271 0.397665654811215 no 1324 0.392763417561654 1741 669075 SGTC_2057 5236571 38.335 µM 0.271164251553265 0.398020923859434 no 1325 0.393132353184266 1929 54684039 YBR257W POP4 SGTC_2268 7933382 153.85 µM 0.268827591989237 0.398886421985321 no 1326 0.394031179670848 1946 935025 YOR257W CDC31 SGTC_3237 9133362 49.47 µM 0.268092749772939 0.399158710374422 no 1327 0.394313963236314 1903 43845137 SGTC_204 PMA1.184 62.41 µM 0.265713157069352 0.400040780604161 no 1328 0.395230064834404 1855 2252213 YGL008C PMA1 SGTC_645 0845-0943 5.41 µM 0.264404490093738 0.400526096579764 no 1329 0.395734126005897 1846 1885106 SGTC_1947 st076332 61.6 µM 0.264249802279499 0.400583472346778 no 1330 0.395793718881495 1945 24208416 SGTC_1136 pergolide 1.05886 µM 0.264075436453527 0.40064814952174 no 1331 0.39586089555462 1820 47811 A dopamine receptor agonist. SGTC_396 dithiazanine 1.25 µM 0.263883785181072 0.400719241495866 no 1332 0.395934735236296 1790 10578 An antihelmenthic. SGTC_2614 arthonioic acid 13.39 µM 0.263677976050789 0.400795588910462 no 1333 0.396014033836447 1827 6710684 SGTC_1530 rhein 70.4 µM 0.262749313807191 0.40114013461739 no 1334 0.396371902416706 1899 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_758 0868-0029 16 µM 0.261602161319787 0.401565849170539 no 1335 0.396814088771276 1959 762687 SGTC_254 nsc-64875 3.808 µM 0.261597668466932 0.401567516722821 no 1336 0.396815820867021 1959 56993 SGTC_300 r073-0011 5.04 µM 0.261589294377157 0.401570624826839 no 1337 0.396819049272257 1966 2735780 SGTC_728 3030-5151 22.5 µM 0.259798366099137 0.402235483579389 no 1338 0.397509655678432 1859 3125388 SGTC_537 1334-0398 209 µM 0.259496051415793 0.402347741925068 no 1339 0.397626264111893 1983 5846986 SGTC_3254 9136651 49.47 µM 0.258887737059861 0.402573651360655 no 1340 0.397860930062132 1831 16454030 SGTC_704 1310-0270 142 µM 0.257992089670248 0.40290632673943 no 1341 0.398206506078809 1790 5718033 SGTC_1548 st061468 90.8 µM 0.257869084496188 0.402952020743271 no 1342 0.398253972559504 1952 390799 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.257531576360557 0.4030774051862 no 1343 0.398384221343909 1823 688667 SGTC_23 0213-0011 39.996 µM 0.257383528707114 0.403132408109739 no 1344 0.398441358434307 1958 627608 SGTC_17 0960-0276 49.807 µM 0.255243612675272 0.403927647008784 no 1345 0.399267474133238 1889 6821114 SGTC_1966 st070145 16.1 µM 0.254421669962685 0.404233204404597 no 1346 0.399584905714444 1822 3748532 SGTC_658 3253-0951 102 µM 0.253852324726163 0.40444489289651 no 1347 0.399804823910293 1877 1184878 SGTC_1191 1487-1166 10.6 µM 0.253635039442579 0.404525689208517 no 1348 0.399888762016624 1924 3955771 SGTC_818 4072-2707 53.5 µM 0.253272892444114 0.404660360581875 no 1349 0.400028671016134 1819 882871 SGTC_1620 st003704 16.5 µM 0.252950561030866 0.404780235259893 no 1350 0.400153208773205 1973 2834414 SGTC_1976 st070609 63.5 µM 0.252198019861671 0.405060139216763 no 1351 0.400444004271065 1897 682556 SGTC_568 1193-0097 7.48 µM 0.252094758531709 0.405098550549589 no 1352 0.400483910623682 1920 3646150 SGTC_1952 st077036 64.1 µM 0.251856710743126 0.405187103471131 no 1353 0.400575910480898 1985 2937007 SGTC_1398 3558-0053 112 µM 0.249440938779694 0.406086035803857 no 1354 0.401509860562365 1861 4532369 SGTC_3183 9108214 49.47 µM 0.24708984359821 0.406961376975166 no 1355 0.4024193468597 1972 4974831 SGTC_1462 k081-0014 26.5 µM 0.245870089277957 0.407415689727611 no 1356 0.402891399243591 1834 3270634 SGTC_1029 k015-0030 64.7 µM 0.244759286871069 0.407829530368647 no 1357 0.403321409771812 1908 2208316 SGTC_2472 5377652 49.4 µM 0.243740830776006 0.408209056863584 no 1358 0.403715774232096 1849 1610903 SGTC_225 nsc-122657 1.016 µM 0.243697568333212 0.408225180472698 no 1359 0.403732528396177 1923 275685 SGTC_1208 2323-2347 50.3 µM 0.242228133780969 0.408772920527794 no 1360 0.404301698223606 2018 5412760 SGTC_1160 4092-0570 10.5 µM 0.24222775072564 0.40877306333712 no 1361 0.404301846622476 1805 4994975 SGTC_2794 7785382 27.27 µM 0.240381474072906 0.409461526011547 no 1362 0.405017269385517 2050 2205081 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.239800500642066 0.409678224507525 no 1363 0.405242459418819 1994 1241132 A phosphatase inhibitor. SGTC_1429 4049-0205 9.46 µM 0.239629171756085 0.409742134098916 no 1364 0.405308873884105 1941 22774478 SGTC_2351 9026858 72.31 µM 0.23920425536478 0.409900647973238 no 1365 0.405473601566635 1827 1409300 SGTC_3298 9116858 71.43 µM 0.238862446874259 0.410028169365651 no 1366 0.405606122895059 1959 2506942 SGTC_515 4092-1064 102 µM 0.237272371662576 0.410621517101604 no 1367 0.406222747191631 2020 717353 SGTC_636 0kpi-0074 126 µM 0.23637999494459 0.410954603469551 no 1368 0.406568909058136 1877 616434 SGTC_795 0685-0265 78 µM 0.234690603644815 0.411585357236591 no 1369 0.407224440639611 1891 302754 SGTC_3014 9081533 49.47 µM 0.234285829871874 0.411736518206041 no 1370 0.407381542977102 2008 21367265 SGTC_3090 9117696 49.47 µM 0.233659412008983 0.411970476993587 no 1371 0.407624700024137 1993 7923821 SGTC_1180 1193-0155 285 µM 0.233652215417682 0.411973165007245 no 1372 0.407627493736844 1881 2921347 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.233150985259116 0.412160390672097 no 1373 0.407822082553028 1860 229346 A bile salt which induces apoptosis. SGTC_2212 7123476 200 µM 0.232318841998839 0.412471267207991 no 1374 0.408145189470833 1965 1085715 SGTC_1701 st028638 40.4 µM 0.232306189557934 0.412475994398979 no 1375 0.408150102678729 1968 3490878 SGTC_1812 st052057 4.327 µM 0.230825715841766 0.413029214832431 no 1376 0.4087251011483 1871 3645418 SGTC_2088 5278280 127.392 µM 0.227116179643216 0.414416143270856 no 1377 0.410166701614087 1928 791502 SGTC_832 4083-0019 164 µM 0.226042797616577 0.414817661334149 no 1378 0.410584066975311 1977 1990758 SGTC_2288 7946289 167.31 µM 0.221923572919289 0.416359354871138 no 1379 0.412186689759067 2002 1246052 SGTC_1654 st012436 41.8 µM 0.221873871545373 0.416377964408925 no 1380 0.412206035543213 2016 4323132 SGTC_467 ro 31-8220 72.8 µM 0.221667665668977 0.416455175464332 no 1381 0.412286301485328 2017 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_373 0844-0104 25.9 µM 0.220994554329212 0.416707235498958 no 1382 0.412548336587531 2027 5375804 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.219956469460499 0.417096034292269 no 1383 0.412952528388653 2098 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_979 1426-2828 121 µM 0.219547392345373 0.41724927015685 no 1384 0.413111833242835 1979 747872 SGTC_672 1441-0018 53.7 µM 0.21946454794004 0.417280304306728 no 1385 0.413144096668135 1880 251141 SGTC_767 0929-0023 86 µM 0.216262770717326 0.418480107651245 no 1386 0.414391463519578 1983 1204563 SGTC_3046 9092212 49.47 µM 0.216198872730804 0.418504059931009 no 1387 0.414416366100101 1950 25236637 SGTC_836 0330-0104 1.35 µM 0.215779913883666 0.418661114920446 no 1388 0.414579652946665 1982 46494820 SGTC_876 0720-0963 56.8 µM 0.214136022398735 0.419277485098045 no 1389 0.415220492719995 2063 765861 SGTC_466 geldanamycin 89.2 µM 0.213705134543178 0.419439077518531 no 1390 0.415388503528351 2049 5288382 HSP90 inhibitor. SGTC_1970 st070122 35.8 µM 0.212651732456972 0.419834183623591 no 1391 0.415799308749591 2012 102928 SGTC_268 camptothecin 39.6153 µM 0.212508837551678 0.419887786342901 no 1392 0.415855041932292 1973 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3348 9149464 3.537 µM 0.211706172464158 0.420188909565972 no 1393 0.416168136160775 2031 1951442 SGTC_1036 k216-0215 33.5 µM 0.211315607134115 0.420335448720861 no 1394 0.416320502582061 1874 622330 SGTC_2426 5582046 32.21 µM 0.211163803907392 0.420392407900814 no 1395 0.416379727092295 1973 2251934 SGTC_1293 1000-1278 195 µM 0.210833363433468 0.420516400608803 no 1396 0.416508651699754 1990 678847 SGTC_798 1287-0182 476 µM 0.210563575515106 0.420617640226705 no 1397 0.416613918776016 2054 1649755 SGTC_3272 9137413 49.47 µM 0.21034178987953 0.420700870618172 no 1398 0.416700460582477 2004 17614870 SGTC_2144 5628481 200 µM 0.210093138055178 0.420794187407811 no 1399 0.416797490503531 1922 2818399 SGTC_253 dyclonine 31.25 µM 0.209760223016223 0.420919134390627 no 1400 0.416927409892846 1968 3180 An oral anasthetic. SGTC_1417 3966-0327 90.4 µM 0.209348000554555 0.42107385743208 no 1401 0.417088291406864 1944 651118 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.209150845253102 0.421147861756826 no 1402 0.417165241768137 1847 23665772 A membrane-active detergent. SGTC_2396 5342950 42.78 µM 0.208919227739221 0.421234805395812 no 1403 0.417255646897407 1910 1886677 SGTC_1302 1159-0335 255 µM 0.208004320289442 0.4215782771395 no 1404 0.417612797014765 1917 649284 SGTC_506 n9-isopropylolomoucine 153 µM 0.207315837204172 0.421836784708198 no 1405 0.417881603260528 2089 6610355 SGTC_2094 5332512 191.667 µM 0.206071063075726 0.422304250589807 no 1406 0.418367700985235 2024 755774 SGTC_1756 st041558 35.5 µM 0.206010898868563 0.42232684759931 no 1407 0.418391198922324 2087 3955792 SGTC_1763 st044482 94.5 µM 0.205989764425785 0.422334785522499 no 1408 0.418399453331203 1995 88505 SGTC_2296 7971656 126.45 µM 0.203973718350353 0.423092140448293 no 1409 0.41918701842905 1910 666570 SGTC_428 3448-4153 16.5 µM 0.202999921947006 0.423458062214997 no 1410 0.419567546609524 1827 3834874 SGTC_3075 9116269 49.47 µM 0.200955926764436 0.424226345077412 no 1411 0.420366518171658 1965 17015205 YNL244C SUI1 SGTC_186 3455-3465 67.277 µM 0.200893177627887 0.424249935363408 no 1412 0.420391051215732 1982 755278 SGTC_2508 celastrol 40.54 µM 0.199063685200807 0.424937844661334 no 1413 0.421106463853159 2058 122724 Celastrol is a natural product and antioxidant. SGTC_2521 angolensin 13.4 µM 0.198462246214058 0.425164042382856 no 1414 0.421341710185803 1974 821428 A flavenoid. SGTC_1737 st035557 69.7 µM 0.195931118866659 0.426116253908678 no 1415 0.422332039985603 1889 5716916 SGTC_814 3342-0569 96 µM 0.195911116439966 0.426123780556234 no 1416 0.422339868106749 2006 4346283 SGTC_2846 9008642 19.48 µM 0.195758138293744 0.426181345091029 no 1417 0.422399738429828 1915 2992898 SGTC_184 1494-0393 24.714 µM 0.195432782222736 0.4263037793809 no 1418 0.42252707743424 1893 3090647 SGTC_1316 1272-0050 65.9 µM 0.194761852353863 0.426556278478716 no 1419 0.422789693878624 1966 7340392 SGTC_1957 st077035 62.4 µM 0.193978115895338 0.426851269550354 no 1420 0.423096508710097 2079 705593 SGTC_313 3474-0040 5.03 µM 0.193944505463165 0.426863921118755 no 1421 0.42310966746714 1937 1043375 YIL048W NEO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.192663333276896 0.427346233244003 no 1422 0.423611320598118 2031 616764 SGTC_1282 0886-0010 32.4 µM 0.191238726222578 0.427882670595613 no 1423 0.424169282168518 2077 2836211 YNL267W PIK1 SGTC_2405 ticlatone 3.52 µM 0.187716755861114 0.429209442625517 no 1424 0.425549347246634 1983 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_287 k060-0039 29.6 µM 0.187668134516989 0.429227764551777 no 1425 0.42556840568293 2073 5861974 SGTC_1969 st069479 40.1 µM 0.186644347696114 0.429613592330744 no 1426 0.425969746625353 2073 3895485 SGTC_3200 9114385 49.47 µM 0.185829901181788 0.429920575451125 no 1427 0.426289077588143 1926 17018030 YLR208W SEC13 SGTC_2760 etidronate 98.04 µM 0.18477090052229 0.430319799842486 no 1428 0.426704366425076 1968 3305 A chelator and antioxidant. SGTC_1531 st059297 52.4 µM 0.184372996340684 0.43046982106737 no 1429 0.426860426227852 2006 7566702 SGTC_1037 k284-1091 78.7 µM 0.184121353828685 0.430564702653245 no 1430 0.426959127460051 1993 3334711 SGTC_844 0330-0132 15.3 µM 0.18161386365816 0.431510367705089 no 1431 0.42794288408315 2073 2828079 SGTC_2872 9044037 25.97 µM 0.181369641289576 0.431602493848185 no 1432 0.428038723207065 2029 6465195 SGTC_3269 9137823 49.47 µM 0.180280822844925 0.432013265732328 no 1433 0.428466055078693 1925 17682936 SGTC_1975 st070967 30.8 µM 0.180111828491028 0.432077027801487 no 1434 0.428532388337545 2117 261391 SGTC_2004 4023728 41.89 µM 0.179748681882043 0.43221405007419 no 1435 0.428674936603005 2105 360084 YDR527W RBA50 SGTC_335 4077-0256 27.6 µM 0.179209910588056 0.432417353971186 no 1436 0.428886441089635 2068 3121989 SGTC_1819 st053448 58.6 µM 0.179064844522416 0.432472097320427 no 1437 0.428943392908635 1996 2857616 SGTC_3204 9114183 49.47 µM 0.177919671495535 0.432904294859363 no 1438 0.429393030852871 1910 17027248 SGTC_571 k831-0106 44.2 µM 0.177893903601971 0.432914020795651 no 1439 0.429403149351901 2120 4783639 SGTC_1983 st071813 46.9 µM 0.176183757183744 0.433559595830805 no 1440 0.430074790535908 1984 11838595 SGTC_2944 9067346 25.62 µM 0.176178974852636 0.433561401395548 no 1441 0.43007666902849 2007 6473075 SGTC_789 1309-1135 70.6 µM 0.175502419297259 0.43381684828305 no 1442 0.430342434979742 2093 3092424 SGTC_2170 morpholine 200 µM 0.170834289138417 0.43558014066543 no 1443 0.432177033273108 2062 121171 Reacts with secondary amines. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.170680137665689 0.435638390337359 no 1444 0.432237640743606 2079 66535 A nucleotide analog. SGTC_1876 myriocin 605 nM 0.170136318740558 0.43584389594356 no 1445 0.432451465825389 2124 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1076 itraconazole 331 nM 0.169847893903709 0.435952896832442 no 1446 0.432564880107338 2105 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1830 st055982 50.3 µM 0.169547822717207 0.436066304248043 no 1447 0.432682879858591 2139 455313 An antimicrobial agent. SGTC_2962 9082311 13.18 µM 0.167566596847826 0.436815210425959 no 1448 0.433462125713629 1990 16459453 SGTC_1925 st057770 10.1 µM 0.166983190303815 0.437035782213812 no 1449 0.433691637705981 1847 5989122 SGTC_2804 7954240 19.48 µM 0.166958958314783 0.437044944161823 no 1450 0.433701171048742 2090 828705 SGTC_3261 9137475 49.47 µM 0.165920893775322 0.437437460849342 no 1451 0.434109602272481 2129 17027690 SGTC_1898 st060199 18.6 µM 0.165593112911477 0.437561415336111 no 1452 0.434238583782053 1948 688866 SGTC_1240 0356-0016 42.1 µM 0.16444869708764 0.437994238650585 no 1453 0.434688965305049 2019 4305613 SGTC_1223 0764-0573 147 µM 0.164444054500141 0.437995994649918 no 1454 0.4346907925549 2047 1609797 SGTC_1914 st062367 72.6 µM 0.16363039755031 0.438303768810396 no 1455 0.435011056720842 1990 978205 SGTC_2646 retinol 96.75 µM 0.162517510421772 0.438724790275547 no 1456 0.435449170126349 2062 445354 A vitamin A analog and teratogen. SGTC_1210 3013-0140 750 nM 0.16184224799274 0.438980285755328 no 1457 0.435715041249184 2145 905973 SGTC_250 brefeldin a 552.239 µM 0.161822131668902 0.438987897453094 no 1458 0.435722962097056 2023 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2915 7971052 15.16 µM 0.161684586715277 0.439039942885591 no 1459 0.435777121423415 2118 5741558 SGTC_336 4111-0029 111 µM 0.160286360783123 0.439569075196759 no 1460 0.436327751241458 2000 3131175 SGTC_1035 k081-0041 55.2 µM 0.159534234999606 0.439853747780174 no 1461 0.436623994035256 2151 731709 SGTC_1550 gossypolone 36.6 µM 0.159012550661601 0.440051218704315 no 1462 0.436829492823524 2133 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3160 9100216 49.47 µM 0.15826859322579 0.440332851493034 no 1463 0.437122577583989 2150 17191039 SGTC_2241 6772625 37.8075 µM 0.156397964301889 0.441041130511307 no 1464 0.437859670841287 2180 2285411 SGTC_3253 9135987 49.47 µM 0.155318415320555 0.441449967738153 no 1465 0.438285149229311 2067 4182430 SGTC_3172 9105863 49.47 µM 0.153531800024096 0.442126715729192 no 1466 0.438989457393095 2126 2348785 SGTC_593 1203-0218 61.7 µM 0.15348647442626 0.442143886716156 no 1467 0.439007327885535 2141 3666956 SGTC_102 gallobenzophenone 83.616 µM 0.152956997573661 0.442344479872055 no 1468 0.439216093561155 2134 70837 SGTC_2984 9022109 38.96 µM 0.15159618391712 0.442860094012222 no 1469 0.439752721706613 2181 6459207 SGTC_2782 7736369 71.43 µM 0.151438842383727 0.442919717191547 no 1470 0.439814775491178 2009 2950836 YOL077C BRX1 SGTC_2895 9054447 58.44 µM 0.151203073856286 0.443009062004299 no 1471 0.439907762794102 2027 2697450 SGTC_2160 5660466 132.927 µM 0.149869312183142 0.443514547289326 no 1472 0.440433861777473 2151 2859134 SGTC_2924 9010168 62.78 µM 0.149795447759178 0.443542544024643 no 1473 0.440463000498227 2029 2993929 SGTC_2257 7960413 200 µM 0.149144712428267 0.443789203541921 no 1474 0.440719722501196 2068 2974689 YIL048W NEO1 SGTC_678 1218-2179 85.9 µM 0.148783738850479 0.443926039025071 no 1475 0.440862141164818 2145 6820081 YOR116C RPO31 SGTC_1747 st037496 66.6 µM 0.147101378584587 0.444563864984654 no 1476 0.4415260008819 2061 723305 SGTC_2133 5320837 200 µM 0.14687356007882 0.444650247902078 no 1477 0.441615910784908 2124 2841355 SGTC_1106 tegaserod maleate 11.7 µM 0.145621991811158 0.445124857180203 no 1478 0.442109903047845 2053 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2142 5622915 118.518 µM 0.145471058912336 0.445182098024032 no 1479 0.442169482153106 2023 5322196 SGTC_2834 9001755 58.44 µM 0.145299343707486 0.445247221884119 no 1480 0.442237266436243 2004 2989575 SGTC_298 1391-0729 10 µM 0.145232182561963 0.445272693490381 no 1481 0.442263778643664 2040 3237558 SGTC_819 1013-0258 27.7 µM 0.143131534717198 0.446069500907567 no 1482 0.443093150119766 2046 5753198 SGTC_380 3970-0968 6 µM 0.142817787787445 0.446188528627256 no 1483 0.443217044234905 2058 2891601 SGTC_1333 1482-0047 286 µM 0.142483005091393 0.44631554213681 no 1484 0.443349251191432 2185 3811116 SGTC_26 0302-0163 425.158 µM 0.142373840357261 0.446356959435463 no 1485 0.443392362123195 2060 3100915 SGTC_2967 9089538 49.85 µM 0.141829901233417 0.446563339642405 no 1486 0.443607182520956 2179 728216 SGTC_2992 9074591 71.4286 µM 0.141773947890733 0.446584570160778 no 1487 0.443629281374932 2180 17741321 SGTC_969 1313-0238 134 µM 0.140898212083992 0.446916872725697 no 1488 0.443975177303973 2053 5212874 SGTC_3176 9106582 49.47 µM 0.140631429554323 0.447018112179674 no 1489 0.444080558891284 2148 17018027 SGTC_1778 st046819 58.9 µM 0.140593862839997 0.447032368389315 no 1490 0.444095398411542 2045 671715 SGTC_1192 1488-0095 21.4 µM 0.139957172235373 0.447273996794009 no 1491 0.444346914427783 2052 915875 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.139520004372617 0.447439916302278 no 1492 0.444519624666423 2145 165506 SGTC_3043 9092303 49.47 µM 0.139063245704396 0.447613280987643 no 1493 0.444700085822531 2047 25236084 SGTC_2431 5490079 200 µM 0.138252842725352 0.447920897478719 no 1494 0.445020296786919 2051 5722345 SGTC_2114 5491910 81.25 µM 0.137399473356253 0.448244857204717 no 1495 0.445357523650456 2131 2849228 SGTC_2588 indole-3-carbinol 100 µM 0.13609809903317 0.448738956872605 no 1496 0.445871865149014 2166 3712 Induces cell cycle arrest. SGTC_2210 7115885 190.385 µM 0.136022890524852 0.448767514122325 no 1497 0.445901592561651 2114 2927039 SGTC_2734 clemastine 41.6 µM 0.13421128225765 0.449455475593898 no 1498 0.446617752338565 2181 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2312 7706453 155.7 µM 0.133923970979227 0.449564596578938 no 1499 0.446731347466899 2053 976098 SGTC_1052 3253-3998 198 µM 0.133641524044432 0.449671873801415 no 1500 0.446843023625649 2152 5450317 SGTC_2679 rapamycin 1 nM 0.13363806898227 0.449673186104235 no 1501 0.446844389742251 2089 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_87 0100-0052 35.5 µM 0.133633855237188 0.44967478657099 no 1502 0.446846055839646 2143 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1798 st045719 60.953 µM 0.133405063136276 0.449761687728901 no 1503 0.446936520698612 2165 3980186 SGTC_713 1488-1073 324 µM 0.133361353111459 0.44977829020118 no 1504 0.446953804045033 2184 3312542 SGTC_3052 9092717 49.47 µM 0.132566703837914 0.450080138833381 no 1505 0.447268033220063 2071 25237534 SGTC_1458 k015-0034 6.33 µM 0.132372063806342 0.450154077530378 no 1506 0.447345005030539 1994 3598957 SGTC_528 3492-0019 172 µM 0.131204506594995 0.450597638446136 no 1507 0.447806765515838 2174 2869262 SGTC_1171 0368-0077 21.4 µM 0.131086621825371 0.45064242690799 no 1508 0.44785339203712 2063 3239779 SGTC_173 1273-0061 2.693 µM 0.130976495357387 0.450684268293163 no 1509 0.447896950597394 2020 2847414 YPL266W DIM1 SGTC_1742 st038235 28.8875 µM 0.130557393705803 0.450843506534701 no 1510 0.448062724521711 2051 564103 YBR002C RER2 SGTC_754 3474-0146 171 µM 0.130541563644122 0.45084952134336 no 1511 0.448068986215075 1967 24762078 SGTC_1613 st002381 52.1 µM 0.130142064901925 0.451001319083329 no 1512 0.448227015060562 2216 551167 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.128768066195824 0.451523452642241 no 1513 0.448770587300303 2068 5711223 A potent inhibitor of glutathione S-transferases. SGTC_895 0964-0006 13.7 µM 0.127464435499094 0.452018923195034 no 1514 0.449286409950187 2178 6738897 SGTC_2651 TUB2.036 5 µM 0.127326379560586 0.452071398466836 no 1515 0.449341041176273 2175 15992207 YFL037W TUB2 SGTC_2151 5563267 85.4165 µM 0.126917805991191 0.452226702803148 no 1516 0.44950272673301 2053 5310824 SGTC_596 1155-0152 116 µM 0.126238299557668 0.452485008560253 no 1517 0.449771647596275 2115 280313 SGTC_1571 st070080 73.4 µM 0.125965699141516 0.45258863981138 no 1518 0.449879538185672 2146 4315245 SGTC_943 3253-1379 105 µM 0.125656868805033 0.452706048061239 no 1519 0.450001772434551 2136 668464 SGTC_2093 5331342 194.4 µM 0.125098790851482 0.452918223436746 no 1520 0.45022267026926 2178 33839 SGTC_2957 9076800 11.52 µM 0.124279897527793 0.453229582394369 no 1521 0.450546831671389 2080 16459615 SGTC_2072 5231554 129 µM 0.121714692359342 0.454205107876453 no 1522 0.451562488467116 2212 789545 SGTC_2065 5221596 34.26 µM 0.121662054448704 0.454225128534805 no 1523 0.451583333048551 2131 788581 SGTC_67 0335-0847 266 µM 0.121251004267925 0.45438147413236 no 1524 0.451746113263599 2195 4552207 YOR254C SEC63 SGTC_2109 5483026 200 µM 0.120560118597434 0.454644272882069 no 1525 0.45201972955395 2079 759335 SGTC_868 0527-0199 213 µM 0.118832707425377 0.455301431318371 no 1526 0.452703947747371 2074 2849450 SGTC_2828 7998861 71.43 µM 0.117053062831319 0.455978588816202 no 1527 0.453409002195826 2204 2988188 SGTC_57 miconazole 162.5 nM 0.115981199190573 0.45638649641138 no 1528 0.453833721050414 2175 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1729 st035615 45.989 µM 0.115568106886681 0.456543714792771 no 1529 0.453997420257184 2047 17385451 SGTC_1865 st057639 52.2 µM 0.114562772919622 0.456926362204842 no 1530 0.454395844139041 2215 688818 SGTC_723 4182-0001 115 µM 0.112810546368439 0.457593385056146 no 1531 0.455090378464307 2065 744821 YLR208W SEC13 SGTC_2727 riluzole 51.77 µM 0.112800453734594 0.457597227382864 no 1532 0.455094379305998 2232 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3128 9127691 49.47 µM 0.112724450350631 0.457626162457877 no 1533 0.455124508109658 2126 41316314 SGTC_3231 9132313 49.47 µM 0.112321621104107 0.457779526408065 no 1534 0.45528419955865 2119 4905967 SGTC_489 paxilline 115 µM 0.112013601220228 0.457896799062833 no 1535 0.455406311114035 2087 105008 A toxic potassium channel blocker. SGTC_2791 5663188 71.43 µM 0.111554032227235 0.458071777941502 no 1536 0.455588510702434 2166 54690634 SGTC_2076 5212012 200 µM 0.11148702765612 0.458097290317675 no 1537 0.455615075950421 2212 604802 SGTC_309 k408-0051 1.48 µM 0.110982573952173 0.458289369504531 no 1538 0.455815082664272 2140 3640463 SGTC_2695 st077686 51.995 µM 0.110945172025032 0.458303611302413 no 1539 0.455829912294283 2103 2876092 SGTC_351 caspofungin 25 nM 0.108919230427899 0.459075122993423 no 1540 0.456633276856441 2133 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3334 9142812 21.919 µM 0.108298723462103 0.459311453167421 no 1541 0.456879367595698 2181 45283678 SGTC_635 k038-0028 24.7 µM 0.107227144844651 0.459719615129896 no 1542 0.457304390550233 2147 4035102 SGTC_2575 plumbagin 510 nM 0.106857108710742 0.459860570971255 no 1543 0.457451170292733 2106 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2893 9048488 25.97 µM 0.106750704355857 0.459901103935129 no 1544 0.457493378067259 2100 6467338 SGTC_2317 5986382 200 µM 0.106051511184918 0.46016746025635 no 1545 0.457770741285969 2181 877883 SGTC_1449 4112-4002 201 µM 0.1054000842426 0.460415636211018 no 1546 0.458029174610832 2056 2059539 SGTC_3305 9127027 53.8275 µM 0.104354217941229 0.460814115051113 no 1547 0.458444126519508 2143 41905295 SGTC_3286 9117135 37.221 µM 0.104083417695546 0.460917297352954 no 1548 0.4585515750698 2104 3438150 SGTC_2806 7952793 58.44 µM 0.102837288298576 0.461392140550118 no 1549 0.459046055178074 2158 2972490 SGTC_3107 9121808 49.47 µM 0.101543929261051 0.461885039019743 no 1550 0.459559343621831 2227 662681 SGTC_743 1275-0778 158 µM 0.101085190602491 0.462059878192728 no 1551 0.459741417005843 2204 2849257 YMR203W TOM40 SGTC_2860 9025725 38.96 µM 0.098564986570631 0.463020534030419 no 1552 0.460741835637348 2062 40546248 SGTC_1056 3448-1962 115 µM 0.0983889888881758 0.463087629261337 no 1553 0.460811708925612 2146 715507 SGTC_3303 9125618 40.5795 µM 0.097194307872746 0.463543102683493 no 1554 0.461286044152138 2176 22695467 SGTC_1979 st071809 45.3 µM 0.0970116623721272 0.463612740703635 no 1555 0.461358566451328 2200 4976333 SGTC_2988 9073640 71.4286 µM 0.0962625254144841 0.463898378951897 no 1556 0.461656036606282 2181 9102229 SGTC_1759 st043059 70 µM 0.0949080998290505 0.464414854692856 no 1557 0.462193911415416 2156 669426 SGTC_352 k048-0007 5.11 µM 0.0947448902534263 0.464477094578047 no 1558 0.462258730530686 2229 6811911 SGTC_3166 9102297 49.47 µM 0.0945397779740709 0.464555315269547 no 1559 0.462340192836893 2134 25237072 SGTC_543 3844-1095 191 µM 0.0937641732816267 0.464851108726697 no 1560 0.462648245920694 2191 4230703 SGTC_295 k015-0027 31 µM 0.0932819608134201 0.46503502057973 no 1561 0.462839781387646 2180 3887424 SGTC_2377 9073351 62.6 µM 0.092879748315264 0.465188426819848 no 1562 0.462999547346741 2095 7337946 YHR072W ERG7 SGTC_2669 eugenol 100 µM 0.0924626616858019 0.465347511606249 no 1563 0.463165227878764 2239 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2865 9030313 51.95 µM 0.0923375236336057 0.465395242724611 no 1564 0.46321493807775 2204 42562754 SGTC_427 1354-0053 47.3 µM 0.0906426159909742 0.466041776189844 no 1565 0.463888284312371 2186 6813657 SGTC_132 0417-1715 25.805 µM 0.0903624972670637 0.466148637962497 no 1566 0.463999578789374 2259 6769098 SGTC_2684 capsaicin 100 µM 0.0894494035635028 0.466496988638707 no 1567 0.464362381213634 2194 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_440 fluspirilene 35.1 µM 0.0892416115389291 0.466576266126081 no 1568 0.46444494802933 2194 3396 An atypical antipsychotic. SGTC_1902 st060212 70.5 µM 0.0892215625515708 0.466583915350982 no 1569 0.464452914638677 2259 688944 SGTC_1080 nisoldipine 24.4 µM 0.0885679253986269 0.466833302151209 no 1570 0.464712649850721 2240 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1246 0422-0085 105 µM 0.0884018127996157 0.466896682343477 no 1571 0.464778660266561 2242 264295 SGTC_1104 tacrolimus 29.8 µM 0.0883182519932535 0.466928565251413 no 1572 0.464811866323778 2247 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_60 0986-0278 202 µM 0.0878147375872454 0.467120687358432 no 1573 0.465011962058583 2012 3110598 SGTC_232 clozapine 119 µM 0.0877236218989532 0.467155454488432 no 1574 0.465048172218893 2256 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3347 9188721 44.724 µM 0.0875769772067539 0.467211410417721 no 1575 0.465106450691871 2163 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2528 xanthyletin 44.79 µM 0.0866118149634497 0.467579708190554 no 1576 0.465490037106279 2183 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2596 sinensetin 100 µM 0.0844141403073215 0.468418425358526 no 1577 0.466363582537014 2185 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2110 5483698 200 µM 0.0839678402169334 0.468588767883639 no 1578 0.466541000615248 2163 2848765 YHR062C RPP1 SGTC_2643 anethole 100 µM 0.0805109575667245 0.4699083732494 no 1579 0.46791544082451 2237 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2253 7938677 135.83 µM 0.080402726364507 0.469949694057601 no 1580 0.467958479300877 2264 2301972 SGTC_1402 3909-7673 35.9 µM 0.0781812540059288 0.470797884777281 no 1581 0.468841936752954 2257 5328014 SGTC_1411 3909-8223 150 µM 0.075751964788108 0.471725574552346 no 1582 0.469808216401407 2294 X1411 SGTC_345 1362-0200 395 µM 0.0739205356041532 0.472425057015741 no 1583 0.470536807750753 2167 1419823 SGTC_1137 ixabepilone 100 µM 0.0730360552761499 0.472762899453802 no 1584 0.470888713075969 2286 154225 A novel microtubule stabilizer. SGTC_3023 9089636 49.47 µM 0.0728323028396978 0.472840728978824 no 1585 0.470969782629999 2299 17249241 SGTC_3197 9113331 49.47 µM 0.072809394051543 0.472849479761664 no 1586 0.470978897714038 2245 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2946 9065502 71.43 µM 0.0726940355817857 0.47289354501167 no 1587 0.471024797454781 2290 16489101 SGTC_154 3389-1638 511.116 µM 0.0712795807177596 0.473433872910083 no 1588 0.471587623056626 2040 5238686 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0687366460758983 0.474405407256751 no 1589 0.472599623911519 2282 77254 SGTC_99 0109-0120 622.8 µM 0.0684289429576252 0.474522976418556 no 1590 0.472722091336908 2272 759414 SGTC_549 1661-1316 519 µM 0.0676107779472878 0.474835596867769 no 1591 0.473047737736451 2282 2857282 SGTC_3119 9125183 49.47 µM 0.067140224531553 0.475015402127764 no 1592 0.4732350357888 2284 22695334 SGTC_1388 3346-4487 254 µM 0.0654673755087042 0.475654662863452 no 1593 0.473900940582092 2232 3345614 SGTC_2360 9040895 200 µM 0.0652467406139482 0.475738980759584 no 1594 0.473988773378623 2213 4914414 SGTC_2850 9015429 58.44 µM 0.0649395214180472 0.475856389546462 no 1595 0.474111076723367 2242 6457570 SGTC_1677 st019204 53.9 µM 0.0641790584696737 0.476147021762516 no 1596 0.474413825966442 2131 3945625 SGTC_655 k060-0012 42 µM 0.0615787249619704 0.477140906991884 no 1597 0.475449159901921 2232 5994525 SGTC_2943 9068529 45.32 µM 0.0611509515782939 0.477304421977365 no 1598 0.475619495775615 2303 3270634 SGTC_121 0557-0495 61.343 µM 0.0599040085893536 0.477781083584705 no 1599 0.476116043619121 2283 3104427 SGTC_174 3553-0389 74.3 µM 0.0599016836739969 0.477781972346408 no 1600 0.476116969463537 2262 738071 SGTC_3301 9125354 19.7965 µM 0.0579245461509607 0.478537826128415 no 1601 0.476904365471937 2283 41905162 SGTC_3341 9147222 25.867 µM 0.0575587315124861 0.478677684518348 no 1602 0.47705006131262 2236 1939759 SGTC_1321 1326-2144 215 µM 0.0573592484015589 0.478753952083577 no 1603 0.477129512296228 2306 3513030 SGTC_661 1304-0007 33.6 µM 0.0566370999829151 0.479030054632405 no 1604 0.477417140225591 2261 3117130 SGTC_2123 5259487 200 µM 0.055919680596776 0.479304359071843 no 1605 0.477702896255449 2291 2173474 SGTC_2560 caryophyllene 100 µM 0.0548327450824193 0.479719966191434 no 1606 0.478135856416167 2321 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2374 9071832 200 µM 0.0545600627026714 0.479824234123118 no 1607 0.478244478342724 2309 17381698 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0538473104907029 0.480096781884007 no 1608 0.47852840792483 2212 2374 Ca(2+)-ATPase inhibitor. SGTC_3216 9129716 49.47 µM 0.0527330984780869 0.480522861575949 no 1609 0.47897228346632 2284 8056934 SGTC_1889 st059080 5.18 µM 0.0525747208028519 0.480583427729973 no 1610 0.479035379491737 2304 176925 Isolated from Daphnopsis sellowiana. SGTC_1694 st024011 44.9 µM 0.0516287497019581 0.480945191482222 no 1611 0.479412255466551 2317 2787533 SGTC_1844 rapamycin 4 nM 0.0505902903730251 0.481342343177461 no 1612 0.479826000039443 2256 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_123 0083-0120 66.675 µM 0.0496267513607546 0.481710858679073 no 1613 0.48020991419466 2284 16001701 SGTC_863 0466-0191 129 µM 0.0494753196110476 0.481768776753501 no 1614 0.480270252602068 2319 765160 YPR165W RHO1 SGTC_1014 4130-3005 69.3 µM 0.0491951110216129 0.481875949096825 no 1615 0.480381903695306 2313 743608 SGTC_1292 0kpi-0043 232 µM 0.0488309484505964 0.482015233564425 no 1616 0.480527009144559 2265 3333905 SGTC_2912 7964298 10.93 µM 0.0480141084561581 0.482327665514241 no 1617 0.480852499326722 2279 2975850 SGTC_1368 1852-0141 284 µM 0.0476697620638021 0.482459377331714 no 1618 0.48098971653631 2277 2838987 SGTC_904 1141-0088 396 µM 0.0464900729572053 0.482910620519421 no 1619 0.481459823082663 2204 1378119 SGTC_2105 5350118 200 µM 0.0459457158160491 0.483118850127902 no 1620 0.481676758338434 2286 2133313 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0454620879454208 0.483303853204395 no 1621 0.481869496536704 2275 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1880 MG-132 525 µM 0.0454554771024155 0.483306382087565 no 1622 0.481872131157858 2313 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3212 9128307 49.47 µM 0.0436934038137147 0.483980461575025 no 1623 0.482574398595643 2163 27243542 SGTC_1021 4476-0760 85.3 µM 0.0430209154200183 0.484237733557165 no 1624 0.482842430596409 2310 746768 SGTC_1984 st072354 53.1 µM 0.0428400138604209 0.484306941679503 no 1625 0.482914533402771 2256 5762938 SGTC_2594 a-mangostin 100 µM 0.0428078110568952 0.484319261664744 no 1626 0.482927368688012 2308 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0412928664563241 0.484898858199565 no 1627 0.48353120998244 2338 4000243 SGTC_2539 epi(13)torulosol 80 µM 0.0396147635745359 0.485540913996904 no 1628 0.484200128524104 2298 6708597 SGTC_1859 st055998 20 µM 0.0386386095443651 0.485914415812014 no 1629 0.484589259649505 2340 676301 SGTC_1982 st072467 71.9 µM 0.0382237595718388 0.486073151917145 no 1630 0.484754638668515 2259 3163533 SGTC_3082 9117008 49.47 µM 0.037973060087812 0.486169079377003 no 1631 0.484854580733385 2297 41448529 SGTC_1815 st051655 58.2 µM 0.0379333475561699 0.486184275023474 no 1632 0.48487041233493 2345 5984156 SGTC_1263 0774-1208 64.8 µM 0.0370652683504326 0.486516442772214 no 1633 0.485216482414874 2334 906585 SGTC_315 k915-0449 187 µM 0.036935499338115 0.486566099281659 no 1634 0.485268217335126 2275 20970215 YNL149C PGA2 SGTC_1354 1498-1681 81 µM 0.0369232747476445 0.486570777069337 no 1635 0.485273090916746 2274 5754243 SGTC_2999 9069765 71.4286 µM 0.0356395749158556 0.487062000024945 no 1636 0.48578487606691 2331 2097066 SGTC_1501 4491-0275 38.4 µM 0.0355400371845892 0.487100090147222 no 1637 0.48582456073545 2350 5104718 SGTC_1109 tnp00067 928.257 nM 0.035197527439009 0.487231159312741 no 1638 0.485961116914499 2298 676295 SGTC_2845 9003024 42.97 µM 0.0328552862770757 0.488127507538397 no 1639 0.48689499495473 2318 2990173 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.032318132083066 0.488333078767328 no 1640 0.487109174722983 2310 676296 Flavone; oxidizing agent. SGTC_2149 5554786 194.827 µM 0.0318957784122341 0.488494717519946 no 1641 0.487277582633735 2320 745063 YPR165W RHO1 SGTC_631 k072-0230 41.5 µM 0.0316275543483181 0.488597370394098 no 1642 0.487384534592771 2324 5773147 SGTC_2166 5933061 31.504 µM 0.0289977094209589 0.489603885562595 no 1643 0.48843320872237 2325 2877375 SGTC_2681 menadione 3.18 µM 0.0289852238822897 0.489608664290249 no 1644 0.488438187638796 2322 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1149 3909-7961 23.3 µM 0.0289084235870125 0.48963805894545 no 1645 0.488468813689965 2278 735261 SGTC_1193 1488-0126 41.5 µM 0.0286107018638991 0.489752009915422 no 1646 0.488587538363189 2356 1384710 SGTC_2607 solasodine 47.35 µM 0.0273726333889773 0.490225881092661 no 1647 0.489081262729674 2319 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2403 6032726 181.2 µM 0.0269053506213176 0.490404737371098 no 1648 0.489267612942479 2328 2881040 SGTC_420 mitomycin C 81.9 mM 0.0266572734680234 0.490499691704772 no 1649 0.489366545921834 2362 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2167 5876490 200 µM 0.0257851927504285 0.490833494691201 no 1650 0.489714336198299 2329 686534 SGTC_3011 9081274 71.4286 µM 0.0251198402620615 0.491088173437311 no 1651 0.489979687467129 2331 6625322 SGTC_1397 3532-0190 20.1 µM 0.0243739679984741 0.491373677266772 no 1652 0.490277156341665 2354 5322280 SGTC_2736 butenafine 14.65 µM 0.0238267664968545 0.491583137028526 no 1653 0.490495394765173 2350 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_164 4100-3994 89.624 µM 0.0231410683156082 0.491845614317714 no 1654 0.490768873334566 2366 4615967 SGTC_2329 6138490 200 µM 0.0209352898909821 0.492689984024103 no 1655 0.491648637762512 2304 720019 SGTC_2469 5655019 90.81 µM 0.0208392622250271 0.492726744087031 no 1656 0.491686938902646 2365 2788239 SGTC_2890 9046729 58.44 µM 0.0201336597535877 0.492996855527968 no 1657 0.491968374491058 2336 903329 SGTC_2522 biochanin a 4.94 µM 0.0186839998441936 0.493551809281425 no 1658 0.492546596151417 2364 5280373 A possible chelator. SGTC_2551 apiole 73.87 µM 0.0180786210140375 0.493783562050776 no 1659 0.492788066562179 2367 10659 A possible DNA adduct former. SGTC_2665 lovastatin 100 µM 0.0178643063497977 0.493865607080025 no 1660 0.49287355193702 2373 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2183 6420625 130.508 µM 0.0170625332398831 0.494172548211025 no 1661 0.49319336435081 2368 2897619 SGTC_1573 oleylamine 1.06 µM 0.0166166788162341 0.494343235236468 no 1662 0.493371209312092 2358 5356789 An amine of the fatty acid oleic acid. SGTC_7 0192-1582 4.227 µM 0.0157784552980247 0.494664136208641 no 1663 0.493705568239867 2377 252616 SGTC_2592 piperlongumine 83.33 µM 0.0149456429485835 0.494982969018111 no 1664 0.494037773086853 2361 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0144790260750118 0.495161609436157 no 1665 0.494223906139182 2369 5357218 A potent inhibitor of glutathione S-transferases. SGTC_8 0354-0001 70 µM 0.0136524537800329 0.495478058174832 no 1666 0.494553628147527 2381 4993152 SGTC_953 1188-0045 9.7 µM 0.0134874574823896 0.495541226463261 no 1667 0.494619446086433 2367 6144426 SGTC_1365 1672-3266 55.4 µM 0.0129908486584475 0.495731352182021 no 1668 0.494817546979244 2380 6415873 SGTC_469 w7 172 µM 0.0106189073097316 0.496639457922041 no 1669 0.495763748516762 2391 45115570 A P450 inhibitor. SGTC_2283 7944793 200 µM 0.00932382041805668 0.497135293953822 no 1670 0.496280387713676 2381 2970533 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0066878670736682 0.498144506000612 no 1671 0.497331946947877 2331 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1205 4161-2785 76 µM 0.00582261985159958 0.498475781050043 no 1672 0.497677123883873 2383 3498106 SGTC_222 nsc-310342 10.666 µM 0.00567033363933588 0.498534086608199 no 1673 0.497737876289518 2394 432556 SGTC_946 3434-1334 87.4 µM 0.00484874259387286 0.498848648256531 no 1674 0.498065639152093 2393 4047976 SGTC_1711 st032263 62.8 µM 0.00444426348888854 0.499003510995978 no 1675 0.498227001225598 2392 3958979 SGTC_452 diindolylmethane 8 µM 0.00404864793703973 0.499154980296104 no 1676 0.498384827571986 2395 3071 Inhibits expression of several cancer promoting factors. SGTC_2754 granisetron 64.02 µM 0.00304627473013448 0.499538759354774 no 1677 0.498784714092031 2398 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_911 3456-4043 236 µM 0.00209694064739844 0.499902231700616 no 1678 0.49916344232934 2402 914281 SGTC_647 0140-0236 81 µM 0.00158622914586598 0.499902231700616 no 1679 0.499367186392682 2399 990837 SGTC_1755 st041960 45.185 µM 0.00126024932629445 0.499777423506097 no 1680 0.499497233392978 2402 2257073 SGTC_2204 7233102 200 µM 0.000293593500427725 0.499407319272598 no 1681 0.499882873141111 2402 2172480 SGTC_90 0870-0863 4.608 µM 0 0.499294910997539 no 1682 0.5 2402 1738164 SGTC_2934 9036370 36.88 µM 0 0.499294910997539 no 1683 0.5 2406 6462800 SGTC_857 0438-0306 1.35 µM -0.000831067825712682 0.498976720019754 no 1684 0.499668451944607 2413 4686136 SGTC_2533 agelasine 13.65 µM -0.000962330807237566 0.498926463410133 no 1685 0.499616085612516 2407 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1329 1447-1697 50.6 µM -0.00114617379525604 0.498856075541519 no 1686 0.499542742912502 2414 2840515 SGTC_1135 dihydrocapsaicin 536.708 nM -0.00171220354301252 0.498639360261348 no 1687 0.499316929947792 2409 107982 A Capsaicinoid. SGTC_1128 3448-9350 235 µM -0.00249288221678129 0.49834046321966 no 1688 0.499005484913728 2413 619386 SGTC_1524 corynanthine 62.1 µM -0.00350498059910672 0.497952964341194 no 1689 0.498601717909987 2449 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2746 daunorubicin 9.88 µM -0.00357657780636992 0.497925552215741 no 1690 0.498573154935906 2413 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2450 5739737 12.93 µM -0.00466050050214793 0.497510556505022 no 1691 0.498140736032481 2417 2262825 SGTC_1344 1488-0097 29.1 µM -0.0047406763526175 0.497479860105578 no 1692 0.498108750849237 2419 747966 SGTC_2098 5376439 882.5 nM -0.00495643369314123 0.497397254589242 no 1693 0.498022677135699 2425 2844116 SGTC_474 dl-dihydrosphingosine 5 µM -0.00511654168229358 0.497335955225982 no 1694 0.497958804099578 2428 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2636 apigenin dimethyl ether 100 µM -0.00567912730095485 0.497120562733806 no 1695 0.497734368182584 2427 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.00693109373765254 0.496641235827028 no 1696 0.497234915797778 2415 97141 SGTC_614 0462-0418 107 µM -0.00759898636542657 0.496385528908727 no 1697 0.496968472226389 2401 5188303 SGTC_3127 9126946 49.47 µM -0.0082700922513346 0.496128593270137 no 1698 0.496700748146571 2434 27243249 SGTC_2820 7989630 71.43 µM -0.00829936315631753 0.49611738681999 no 1699 0.496689071145731 2421 2984098 SGTC_1468 k284-1086 134 µM -0.00947482139389476 0.495667361880804 no 1700 0.49622014970108 2425 15996457 SGTC_750 4073-0104 132 µM -0.00976926230921487 0.495554635828892 no 1701 0.496102690208845 2428 22330957 SGTC_1122 capsaicin 818.572 nM -0.0100072114455338 0.49546353778829 no 1702 0.49600776687879 2441 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1568 digitonin 820 nM -0.0101118671344484 0.495423470778219 no 1703 0.495966017412074 2429 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3047 9092122 49.47 µM -0.0101624144016902 0.495404118976526 no 1704 0.495945853006105 2429 17173831 SGTC_3203 9113543 49.47 µM -0.0111691286822112 0.495018705099713 no 1705 0.49554425497556 2462 17018012 SGTC_1309 pyrazolanthrone 13.4 µM -0.0117165548822397 0.494809128543068 no 1706 0.495325877819167 2424 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2889 9059656 51.95 µM -0.0117771888397171 0.494785915535809 no 1707 0.495301690038786 2434 3949838 SGTC_38 0929-0051 58.268 µM -0.0131581520428222 0.494257234727335 no 1708 0.494750808290125 2442 1379719 SGTC_3040 9091894 49.47 µM -0.0132234292939645 0.494232244564571 no 1709 0.494724768700204 2436 25236966 SGTC_1314 1222-0010 41.1 µM -0.014125440175557 0.493886929094349 no 1710 0.494364952077009 2443 3526027 SGTC_210 3551-0445 56.827 µM -0.0155677631537426 0.493334776381886 no 1711 0.493789611921069 2430 2865180 YOR207C RET1 SGTC_1455 4262-0120 131 µM -0.016045996665121 0.493151700924025 no 1712 0.493598848188651 2468 1529587 SGTC_3077 9117319 49.47 µM -0.0167245967482079 0.492891924413956 no 1713 0.493328162268256 2430 17154678 SGTC_146 3448-8650 53.125 µM -0.0167817937314214 0.492870028837133 no 1714 0.49330534717532 2470 2891488 YIL048W NEO1 SGTC_3192 9110362 49.47 µM -0.0181570361935204 0.492343578898205 no 1715 0.492756788565678 2431 16649480 SGTC_2357 9067248 200 µM -0.0181685921350381 0.492339155279142 no 1716 0.492752179172371 2448 9150235 SGTC_682 0kpi-0099 17 µM -0.0184816999266105 0.492219297850944 no 1717 0.492627288208138 2466 1714895 YML126C ERG13 SGTC_2277 7947813 106.88 µM -0.0205489646212186 0.491427968610878 no 1718 0.491802726094923 2563 1246798 SGTC_3018 9082602 49.47 µM -0.0207043418767072 0.491368493001341 no 1719 0.491740752723319 2433 17332089 SGTC_1043 0916-0009 19.3 µM -0.0211349457110899 0.491203666630938 no 1720 0.491569004234394 2436 3101130 SGTC_2933 9026794 32.47 µM -0.0216578942688321 0.491003494605199 no 1721 0.491360425696412 2462 17586027 SGTC_727 3032-0951 202 µM -0.0231803522020358 0.490420747712398 no 1722 0.490753205534145 2467 3652836 SGTC_1089 terbinafine 2.25 µM -0.0237407582439542 0.49020624776807 no 1723 0.490529697390398 2451 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_128 0906-2981 13.371 µM -0.0244163046568735 0.489947680686364 no 1724 0.490260271483648 2454 6740226 SGTC_2544 sphondin 68.51 µM -0.0250054480980409 0.489722188003276 no 1725 0.490025309007359 2445 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_796 1234-0020 70.7 µM -0.0251916168314572 0.489650933222388 no 1726 0.489951061817602 2453 46495034 SGTC_1602 st001878 87.6 µM -0.02533389729787 0.489596476591352 no 1727 0.489894318233885 2536 595405 YLR310C CDC25 SGTC_2213 7173844 200 µM -0.0284299271254284 0.488411547430225 no 1728 0.488659627724489 2449 892728 SGTC_1503 4585-0012 61.3 µM -0.0307049421517367 0.48754090606665 no 1729 0.487752424877605 2496 2922052 SGTC_1372 2752-0194 270 µM -0.0314560148247983 0.487253485661625 no 1730 0.48745293492771 2467 823334 SGTC_1058 3448-5425 97.3 µM -0.031620563925912 0.487190516909275 no 1731 0.487387321973675 2459 7279705 SGTC_1645 Cervolide 78 µM -0.03166669529555 0.487172863665648 no 1732 0.487368927431586 2491 23173 A fragrance. SGTC_195 4234-0266 16.654 µM -0.0323623003422141 0.486906677250808 no 1733 0.487091563349143 2475 2303354 SGTC_280 3448-3607 3.04 µM -0.0330954412028467 0.486626133363607 no 1734 0.486799239076634 2460 626179 SGTC_2856 9022925 19.48 µM -0.0338175427538856 0.486349820250705 no 1735 0.486511323425833 2507 4944862 SGTC_429 1112-0049 25.5 µM -0.0352534864905991 0.485800374084243 no 1736 0.485938806329039 2487 2836170 SGTC_1714 st033236 13.627 µM -0.0361030026195936 0.485475329835678 no 1737 0.485600114073068 2495 2916566 SGTC_3086 9117350 49.47 µM -0.0364229291618902 0.48535292113288 no 1738 0.485472565740044 2485 2679265 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.0376999260324789 0.484864336803938 no 1739 0.484963467486886 2482 364106 SGTC_129 0088-0017 176.636 µM -0.0378208960681668 0.484818054330471 no 1740 0.484915241818528 2468 182446 SGTC_1712 st032288 53.4 µM -0.0378982177643916 0.484788471579859 no 1741 0.484884417023936 2480 2883011 SGTC_2713 st079149 53.4 µM -0.0389862647303691 0.484372201227217 no 1742 0.484450669723125 2502 3103253 SGTC_3265 9137266 49.47 µM -0.0396205566185259 0.484129538550456 no 1743 0.484197819246909 2474 17224265 SGTC_1901 st060216 58.6 µM -0.0409048974923079 0.483638203058212 no 1744 0.483685856541381 2469 688792 SGTC_1156 4092-0367 4.88 µM -0.0409938112502367 0.483604189257108 no 1745 0.483650414811731 2493 1357585 SGTC_1445 4239-0156 97.7 µM -0.0410574131723506 0.483579858527292 no 1746 0.483625062659983 2539 4008346 SGTC_1262 0737-0114 49.6 µM -0.0411385157540026 0.483548833059915 no 1747 0.483592734724285 2476 765919 SGTC_1230 0170-0365 3.77 µM -0.0418422944415495 0.483279609548015 no 1748 0.483312209215345 2533 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_695 3505-6186 243 µM -0.0420554444885261 0.483198072623625 no 1749 0.48322724943478 2516 1819379 SGTC_938 3126-1755 342 µM -0.0421491608704162 0.483162223238216 no 1750 0.48318989512956 2476 1777771 SGTC_259 usnic acid 108.925 µM -0.0447301083493528 0.48217498630947 no 1751 0.482161217358397 2543 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2252 omeprazole 400 µM -0.0466831197697028 0.481428013202699 no 1752 0.481382892074597 2559 4594 A proton pump inhibitor. SGTC_2983 9022671 12.99 µM -0.0495421883929886 0.480334616473636 no 1753 0.480243608491648 2589 6405161 SGTC_1022 4477-0945 21.3 µM -0.0512519382764377 0.479680825124112 no 1754 0.479562382717054 2500 4648966 SGTC_1516 st013856 110 µM -0.0513258913928169 0.47965254740863 no 1755 0.479532918471294 2634 5281404 A mutagen and neurotoxin. SGTC_800 3448-7362 155 µM -0.0531924860444482 0.478938845282179 no 1756 0.478789271204645 2498 15991913 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0537247063899108 0.478735360350097 no 1757 0.478577249185947 2483 2346 DNA damaging agent; causes G2/M arrest. SGTC_933 2914-0560 114 µM -0.0542893824381281 0.478519472621514 no 1758 0.478352304333068 2498 463887 SGTC_2205 7238770 200 µM -0.0556767375648998 0.477989083983113 no 1759 0.477799665742039 2551 279867 SGTC_404 fumagillin 50 µM -0.0559931607377958 0.477868120197029 no 1760 0.477673627777893 2521 12015870 A methionine aminopeptidase binder. SGTC_1915 st067105 30.6 µM -0.056527387731709 0.477663897942117 no 1761 0.477460839073204 2493 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2335 9018011 154.17 µM -0.056784800979707 0.477565497079437 no 1762 0.477358310730977 2581 6458208 SGTC_2069 5228469 200 µM -0.0579328547766415 0.477126649520008 no 1763 0.47690105636676 2577 2835210 SGTC_1803 st050068 52.4 µM -0.0586896531875459 0.476837375829319 no 1764 0.476599650346648 2493 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3297 9117502 71.43 µM -0.0591480416968984 0.476662170319352 no 1765 0.476417096926924 2496 7453720 SGTC_2885 9057732 51.95 µM -0.0592230965915351 0.47663348322487 no 1766 0.476387206753599 2583 6471414 SGTC_3293 9120939 62.045 µM -0.0604446074225255 0.476166620788512 no 1767 0.475900765997948 2552 934087 SGTC_1212 0520-0165 585 µM -0.0611239097766475 0.475907004989035 no 1768 0.475630263750623 2651 5403258 SGTC_19 0279-0214 38.434 µM -0.0617644285718787 0.475662220858013 no 1769 0.475375215633404 2528 3566274 YBR002C RER2 SGTC_950 1165-0508 94.1 µM -0.0623155377115042 0.475451613353149 no 1770 0.475155777609915 2561 6148369 SGTC_3226 9131256 49.47 µM -0.063096258236756 0.475153271133407 no 1771 0.474844926929286 2505 17178073 SGTC_1232 0279-0259 161 µM -0.0633884175652071 0.475041629809591 no 1772 0.474728605073774 2540 1560000 SGTC_513 4245-1575 41.7 µM -0.0646029196591796 0.47457755954791 no 1773 0.474245080008253 2652 719745 SGTC_1085 doxorubicin 7.67 µM -0.0651066900825128 0.474385075215888 no 1774 0.474044526910488 2521 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0660274944765461 0.474033262942242 no 1775 0.473677967892689 2590 5377381 SGTC_2395 5646831 180.19 µM -0.0674162772086482 0.473502688301223 no 1776 0.473125155664917 2602 6808628 SGTC_3084 9116877 49.47 µM -0.0694292826080275 0.472733717484329 no 1777 0.472323960500594 2516 27241325 SGTC_2916 7875993 68.79 µM -0.0697630163924816 0.472606240464288 no 1778 0.472191142035363 2536 1299250 SGTC_1375 2910-0797 186 µM -0.0705250258872591 0.472315184576871 no 1779 0.471887891180502 2576 742508 SGTC_996 3970-0799 1.8 µM -0.0713158869359441 0.472013124232343 no 1780 0.471573175738366 2524 6615648 YGL040C HEM2 SGTC_2019 4016004 108 µM -0.0715556116409001 0.471921567290431 no 1781 0.471477783126323 2584 45595336 SGTC_258 haloperidol 50.781 µM -0.0722666163523634 0.471650025312002 no 1782 0.47119486575016 2543 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2048 5246248 200 µM -0.0739639879890801 0.471001830448671 no 1783 0.470519520081682 2557 677046 SGTC_2100 5377183 190 µM -0.0744591894563408 0.470812736556957 no 1784 0.470322506540958 2606 2844202 SGTC_1437 4092-1038 11.6 µM -0.0751371618039475 0.47055386183794 no 1785 0.470052790267866 2542 3977136 SGTC_83 0170-0301 39.027 µM -0.0758111331085789 0.470296527197411 no 1786 0.469784679338669 2532 3089716 SGTC_332 4112-0506 40.9 µM -0.0760562131101011 0.470202954214845 no 1787 0.469687188033428 2542 2790355 SGTC_1305 1181-0477 144 µM -0.0767745386323136 0.469928702813548 no 1788 0.46940145308412 2614 6252086 SGTC_2001 4023502 57.655 µM -0.0782585136069042 0.469362177401984 no 1789 0.468811208777754 2616 108941 YCR052W RSC6 SGTC_2008 4012253 172 µM -0.081152024918955 0.468257723833418 no 1790 0.467660526091247 2573 603940 SGTC_472 calcifediol 10 µM -0.08242346816169 0.467772490562305 no 1791 0.467154987323211 2624 5283731 A vitamin D metabolite. SGTC_637 1181-0519 7.26 µM -0.0827448416148964 0.467649849232951 no 1792 0.46702721432427 2552 6252091 YGR060W ERG25 SGTC_508 roscovitine 141 µM -0.0827960905855407 0.467630292076967 no 1793 0.467006838858384 2550 160355 A CDKinase inhibitor. SGTC_2217 6934799 96.0675 µM -0.0848715488719077 0.46683834114405 no 1794 0.466181755432843 2567 675606 SGTC_2808 7946468 45.46 µM -0.0858532052133706 0.466463807405982 no 1795 0.465791555463915 2617 2970879 SGTC_2040 5100729 123 µM -0.086030967158975 0.466395988623276 no 1796 0.465720900122134 2556 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1736 st036774 51 µM -0.0864728381013 0.466227412626042 no 1797 0.465545273615787 2665 1272247 SGTC_2425 5628681 7.85 µM -0.0866969949757683 0.466141897960348 no 1798 0.465456182543557 2622 5714958 SGTC_153 4077-0274 519.67 µM -0.0870456014819355 0.466008909523658 no 1799 0.465317632449918 2579 3121976 SGTC_1643 st009866 20.2 µM -0.0880274139173885 0.465634382453619 no 1800 0.464927443778751 2572 3156273 YOR207C RET1 SGTC_1922 5578187 25 µM -0.0887295654456799 0.465366554875881 no 1801 0.464648417685766 2708 1350412 SGTC_2127 5253358 187.912 µM -0.0900681426655264 0.464856013641034 no 1802 0.464116532384055 2564 20612 SGTC_1271 0832-2808 169 µM -0.0902608198121251 0.464782530185696 no 1803 0.464039977140281 2637 3663794 SGTC_2281 7943571 200 µM -0.0914567466938453 0.464326453030207 no 1804 0.463564836642356 2611 1244024 SGTC_2193 5925765 200 µM -0.0916527921060637 0.46425169385638 no 1805 0.463486952944979 2648 877370 SGTC_2844 9010103 25.97 µM -0.0922706039564561 0.464016108222902 no 1806 0.46324152167812 2727 2480525 SGTC_2691 st077356 60.2 µM -0.0926547417808786 0.463869634136858 no 1807 0.463088926549817 2684 2839272 SGTC_1774 st048371 48.465 µM -0.0928184956159333 0.463807195292371 no 1808 0.46302387853284 2575 4242727 SGTC_2286 7945697 125 µM -0.0933231737775199 0.463614768642166 no 1809 0.462823411203315 2631 1245733 SGTC_2391 6285546 200 µM -0.0945004391773152 0.463165927148284 no 1810 0.462355816797433 2554 846083 SGTC_1919 st067113 52.3 µM -0.0950391140894275 0.462960568793069 no 1811 0.462141879481275 2679 1268243 SGTC_1784 st039334 36.3 µM -0.0956902443529399 0.4627123524084 no 1812 0.461883294611082 2800 3496984 SGTC_2457 5731572 11.68 µM -0.0964099835841596 0.462437998600266 no 1813 0.46159748165397 2647 2865357 SGTC_2024 5144227 134 µM -0.0964273991839225 0.462431360255541 no 1814 0.461590566055366 2665 3475211 SGTC_737 1950-0117 57.9 µM -0.0984412713391548 0.461663798955105 no 1815 0.460790952010134 2586 5393513 SGTC_1459 k035-0031 35.7 µM -0.098823228474462 0.461518236957415 no 1816 0.460639312555909 2569 3877128 YMR208W ERG12 SGTC_1440 4100-1550 40 µM -0.0998714424100334 0.461118794291694 no 1817 0.460223194313689 2590 742806 SGTC_3262 9137218 49.47 µM -0.0999830700953417 0.461076258656839 no 1818 0.460178883097442 2543 17650664 SGTC_3069 9117009 49.47 µM -0.100156154733299 0.461010305782998 no 1819 0.460110177188007 2585 41904981 SGTC_2465 5809242 33.21 µM -0.101131175699897 0.460638799919606 no 1820 0.459723165138245 2594 2731748 SGTC_165 k038-0023 64.381 µM -0.101326975877547 0.460564199589899 no 1821 0.459645451369957 2604 46368543 SGTC_456 gingerol 170 µM -0.101916361236683 0.460339650765034 no 1822 0.459411531598296 2718 442793 A herb. SGTC_2735 sertaconazole 140 nM -0.101948506015229 0.460327404349078 no 1823 0.459398774135922 2582 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3181 9108277 49.47 µM -0.102354840976044 0.460172603390536 no 1824 0.459237513514324 2598 17097298 SGTC_1269 0831-0796 3.05 µM -0.103173748674199 0.459860643440886 no 1825 0.458912537113827 2651 927758 SGTC_1879 gemcitabine 100 µM -0.103256925664976 0.459828958843772 no 1826 0.458879530580548 2591 60750 A nucleoside analog which inhibits DNA replication. SGTC_2970 9090938 41.86 µM -0.103477365801623 0.459744987854099 no 1827 0.458792056261799 2628 17217104 SGTC_493 zm226600 134 µM -0.103568829095172 0.45971014779613 no 1828 0.45875576268859 2753 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2327 6189656 200 µM -0.103979585092577 0.459553687067861 no 1829 0.458592774738095 2676 5349088 SGTC_937 3122-0005 46.7 µM -0.105186756605035 0.459093900707483 no 1830 0.45811380956077 2628 759535 SGTC_2370 9071495 200 µM -0.105650786490545 0.458917175961497 no 1831 0.457929714205635 2649 21791103 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.105926978234398 0.458811992804512 no 1832 0.457820144473639 2595 5106787 A p450 inhibitor. SGTC_3238 9133470 49.47 µM -0.106217999565868 0.45870116515911 no 1833 0.457704695072874 2646 3534688 SGTC_1153 4055-0057 267 µM -0.107461507087067 0.45822764503853 no 1834 0.457211430668092 2594 882706 SGTC_762 1165-0429 115 µM -0.11062687224216 0.457022562225794 no 1835 0.455956118654079 2617 5967793 SGTC_2644 guaiazulene 100 µM -0.111113660386352 0.456837272403077 no 1836 0.45576310819968 2674 3515 A coloring agent. SGTC_84 0443-0269 128.823 µM -0.111428434069565 0.456717462728124 no 1837 0.455638306664827 2597 6150058 SGTC_1740 st038286 13.222 µM -0.112413525225705 0.456342541191321 no 1838 0.455247765860936 2742 716786 SGTC_46 0329-0187a 2.197 µM -0.11307953173322 0.45608908392524 no 1839 0.45498375110369 2662 46494817 SGTC_1845 st056753 3.01 µM -0.113882556456703 0.455783506398667 no 1840 0.454665446763745 2567 5375839 SGTC_3188 9110789 49.47 µM -0.114032678003798 0.45572638306998 no 1841 0.454605944546496 2704 849217 SGTC_2797 7859098 81.82 µM -0.114856990328721 0.455412737150238 no 1842 0.454279238076659 2648 972681 SGTC_2686 alizarin 95.37 µM -0.116049029125386 0.454959222701686 no 1843 0.453806842318811 2668 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1743 st037606 46.3785 µM -0.116466519770142 0.454800401083003 no 1844 0.453641409421077 2647 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2880 9042983 58.44 µM -0.117051078893324 0.454578035488979 no 1845 0.453409788269018 2739 6464714 SGTC_2996 9066192 71.4286 µM -0.117151184918044 0.454539956702018 no 1846 0.453370124624998 2645 6472854 SGTC_516 3992-2719 87.3 µM -0.117629921111023 0.454357858624475 no 1847 0.453180447954802 2581 5350887 YDR037W KRS1 SGTC_1670 st016595 4.04 µM -0.117970310088823 0.454228389854387 no 1848 0.453045591347682 2600 597879 SGTC_2662 daunorubicin 22.37 µM -0.120290683264552 0.45334595376694 no 1849 0.452126442100075 2582 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2350 9023895 38.85 µM -0.121566282336317 0.452860942274247 no 1850 0.451621259090683 2734 2997209 SGTC_2487 5918373 44.05 µM -0.122321498368887 0.452573825225259 no 1851 0.451322203304646 2602 2876279 SGTC_2262 9014885 67.46 µM -0.124111242844829 0.451893501781381 no 1852 0.450613598242598 2671 6457424 SGTC_1708 st033234 31.827 µM -0.124486991805495 0.451750688747076 no 1853 0.450464849649186 2727 674664 SGTC_433 pimozide 108 µM -0.124853283653647 0.45161147614087 no 1854 0.450319851561402 2614 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1769 st044406 64.4 µM -0.125002266654894 0.451554855474023 no 1855 0.450260877942584 2635 670903 SGTC_2255 7941087 197.44 µM -0.125327339857863 0.451431315530205 no 1856 0.450132204370893 2700 935561 SGTC_2977 9011197 71.43 µM -0.126478050053771 0.450994040605364 no 1857 0.449676761512561 2854 2704722 SGTC_3035 9091303 49.47 µM -0.127847765634918 0.450473620235895 no 1858 0.44913472434193 2629 25237002 SGTC_2502 avocadyne acetate 18.59 µM -0.128496903304529 0.450227011513392 no 1859 0.448877874357621 2605 3952079 SGTC_1325 1431-0015 227 µM -0.129010719205737 0.450031825427101 no 1860 0.448674583506763 2632 1103340 SGTC_1930 st074634 34.3 µM -0.130872582295739 0.449324650797631 no 1861 0.447938052131737 2640 684253 YOR116C RPO31 SGTC_1750 st081859 2.357 µM -0.133122208148213 0.448470410637957 no 1862 0.447048365948884 2657 5291695 SGTC_2386 9075165 157.42 µM -0.133253870430166 0.448420422481046 no 1863 0.446996304115628 2626 16452277 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.135108517751778 0.447716356782285 no 1864 0.446263037869841 2705 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1691 st019933 84.6 µM -0.135390409437505 0.447609358743204 no 1865 0.446151603237848 2624 6176082 SGTC_103 0844-0104 51.839 µM -0.135990879786528 0.447381450054689 no 1866 0.445914245430166 2788 5375804 SGTC_1693 xanthone 101.9 µM -0.136406174954804 0.447223834815927 no 1867 0.445750096199594 2689 7020 An insecticide. SGTC_1175 0741-0056 27.6 µM -0.136872502047347 0.447046861579337 no 1868 0.445565787216217 2798 765927 SGTC_1973 st070275 50.2 µM -0.138440576493606 0.446451847786054 no 1869 0.444946115168284 2597 17118334 SGTC_1283 0922-0125 16.4 µM -0.139341074588597 0.446110203624835 no 1870 0.444590316813203 2755 3360884 SGTC_1119 parthenolide 318.541 nM -0.13984793715901 0.44591792025569 no 1871 0.444390068523353 2837 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_247 mechlorethamine 29.705 µM -0.140182594076867 0.445790971785814 no 1872 0.444257862008543 2646 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3229 9132204 49.47 µM -0.140391016857983 0.445711911673222 no 1873 0.444175527535588 2636 17682924 SGTC_1718 roemerine 11.9335 µM -0.141819632827189 0.445170059224113 no 1874 0.443611238029776 2717 235224 An aporphine alkaloid with mutagenic activity. SGTC_843 0310-0051 143 µM -0.141859402327121 0.445154976714359 no 1875 0.443595531091746 2668 2065037 SGTC_1129 3453-1384 223 µM -0.142388052491249 0.444954494661442 no 1876 0.443386749482024 2883 1084452 SGTC_632 0781-2353 4.65 µM -0.143595538046311 0.444496628114556 no 1877 0.442909932132124 2743 6811515 YHR007C ERG11 SGTC_1656 st012921 11 µM -0.144456759053888 0.44417010685914 no 1878 0.442569899758584 2767 6732821 SGTC_285 1486-1325 46 µM -0.144721197944916 0.444069855728961 no 1879 0.442465500907924 2753 22310230 SGTC_499 genistein 192 µM -0.145937330729855 0.443608855168999 no 1880 0.441985430698115 2719 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2545 solidagenone 89.61 µM -0.148623995894266 0.442590689926286 no 1881 0.440925168658913 2640 6708572 An anti ulcer agent SGTC_2639 lactacystin 53 µM -0.148658456805336 0.442577632725936 no 1882 0.440911571783343 2769 3870 A proteasome inhibitor. SGTC_11 0438-0307 1.3 µM -0.149453937909854 0.442276243198644 no 1883 0.440597726649299 2771 4011476 SGTC_1713 st033146 12.748 µM -0.150068633606897 0.442043371984448 no 1884 0.440355233229819 2763 674619 SGTC_2515 chrysin 20.77 µM -0.150186009364036 0.441998907647227 no 1885 0.440308931804362 2778 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_835 0312-0010 67.2 µM -0.151620221371161 0.441455657994688 no 1886 0.439743241727223 2669 1626196 SGTC_2441 5730946 39.09 µM -0.153356923273139 0.440797978964745 no 1887 0.439058406615399 2799 1774275 SGTC_3095 9117207 49.47 µM -0.154399659000917 0.440403179257328 no 1888 0.438647311256567 2815 17015229 SGTC_546 peri-Naphthalide 147 µM -0.156113398210171 0.439754453649375 no 1889 0.437971818802249 2781 223824 A penicillin ester. SGTC_2961 9083290 32.55 µM -0.156190658249543 0.439725211125896 no 1890 0.437941370001612 2664 17741490 SGTC_1072 oxiconazole 14.9 nM -0.157786500130803 0.439121267043422 no 1891 0.437312518364703 2692 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_702 1488-0190 94 µM -0.158542794865771 0.43883509778059 no 1892 0.437014550817977 2775 949357 SGTC_1828 st055811 49 µM -0.161443985322292 0.437737633725202 no 1893 0.435871862868292 2814 5877589 SGTC_2569 tetrandrine 100 µM -0.162515918648411 0.437332262827998 no 1894 0.435449796821125 2757 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2451 5856223 45.7 µM -0.163779768664261 0.436854399702648 no 1895 0.434952259434939 2736 2179896 SGTC_236 1509-0011 5.31 µM -0.164300634546259 0.436657486488465 no 1896 0.43474724109334 2781 3107280 SGTC_2825 7998094 58.44 µM -0.167546563915249 0.435430719253009 no 1897 0.433470006292888 2789 2987815 SGTC_1617 st002906 78 µM -0.167802967969811 0.435333840167266 no 1898 0.433369143753981 2690 5150859 SGTC_653 0203-0016 55.2 µM -0.168592426216487 0.435035577576222 no 1899 0.433058619144623 2778 295302 SGTC_2764 methyldopa 94.69 µM -0.168631276874896 0.4350209004912 no 1900 0.4330433387362 2834 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3205 9113483 49.47 µM -0.170582272822939 0.434283964618241 no 1901 0.43227611892384 2888 17018033 SGTC_2225 6654152 15.4 µM -0.170925502509862 0.434154342444157 no 1902 0.432141171819604 2699 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_381 3461-2219 42.7 µM -0.171121971362647 0.434080148318225 no 1903 0.432063930015479 2809 2883159 SGTC_652 0437-0092 114 µM -0.171769995586308 0.433835446151469 no 1904 0.431809177469767 2714 3091274 SGTC_3182 9108849 49.47 µM -0.172739623116966 0.433469349878012 no 1905 0.431428048592736 2789 17133045 SGTC_2884 9058502 51.95 µM -0.173709260315442 0.433103307030539 no 1906 0.431046979747662 2810 6471554 SGTC_1753 st043925 64 µM -0.175194556018343 0.432542711923435 no 1907 0.430463380923709 2788 670181 SGTC_1307 1187-1599 12.2 µM -0.1753696522647 0.432476634276796 no 1908 0.430394592507654 2714 1538471 SGTC_1182 1222-0449 220 µM -0.17545874906968 0.432443011738309 no 1909 0.430359590694288 2777 658318 SGTC_1278 0874-0585 172 µM -0.176861689563431 0.4319136475217 no 1910 0.429808515735355 2778 766306 SGTC_3050 9093513 49.47 µM -0.178106281222194 0.431444134526043 no 1911 0.429319754601199 2746 25236664 SGTC_3351 9150312 21.596 µM -0.179162907519328 0.431045606054308 no 1912 0.428904893969965 2688 4904905 SGTC_2173 5763948 167 µM -0.179194007875716 0.431033876972897 no 1913 0.428892684299664 2712 2867177 SGTC_446 go6976 132 µM -0.179573215195216 0.430890868924261 no 1914 0.428743817001371 2857 3501 A protein kinase C inhibitor. SGTC_638 3970-0837 4.09 µM -0.180251506046042 0.430635092013718 no 1915 0.428477562293512 2750 4118451 YLR208W SEC13 SGTC_989 1501-0895 10.3 µM -0.180323383206946 0.430607989535619 no 1916 0.428449349705869 2739 2830112 SGTC_2955 9076254 12.21 µM -0.180871153533395 0.430401454376172 no 1917 0.428234355763048 2798 16459619 SGTC_564 3555-0129 330 µM -0.182744720948214 0.429695175657282 no 1918 0.427499162164959 2716 563260 SGTC_1248 0469-0687 58.6 µM -0.185036950012869 0.428831380225992 no 1919 0.426600027021707 2835 4017482 SGTC_718 1130-0073 349 µM -0.185601100582914 0.428618839830631 no 1920 0.426378795211345 2880 6740020 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.186269375674168 0.428367097924995 no 1921 0.426116760915737 2860 6708760 SGTC_2136 5328288 199.296 µM -0.186563259615797 0.428256399887367 no 1922 0.426001537743651 2779 262395 SGTC_2195 6536160 144.242 µM -0.187205037528124 0.428014679348739 no 1923 0.425749937644067 2727 3834386 SGTC_2708 st078559 56 µM -0.188948239495775 0.427358252789295 no 1924 0.425066692412274 2772 17250902 SGTC_2460 5552655 174.22 µM -0.189259366622946 0.427241114704277 no 1925 0.424944770236653 2846 5401989 SGTC_2294 7971431 200 µM -0.191007344959777 0.426583127587422 no 1926 0.424259919329612 2871 5741572 SGTC_2381 9035592 200 µM -0.191122007084312 0.426539972729936 no 1927 0.424215003136983 2798 4749657 SGTC_2306 7482397 179.52 µM -0.191209997391727 0.426506856818183 no 1928 0.424180535669361 2896 891448 SGTC_1112 tnp00069 1.16933 µM -0.19142070005967 0.426427559156507 no 1929 0.424098001806611 2861 145826 SGTC_1590 st077108 57.8 µM -0.193119474580066 0.425788336603269 no 1930 0.423432700615226 2759 5489485 SGTC_2710 st078562 53.7235 µM -0.194449899424372 0.425287854383311 no 1931 0.422911810689011 2713 17250908 SGTC_1607 st000305 50.6 µM -0.194695659658482 0.42519541689157 no 1932 0.422815604991302 2901 5457690 SGTC_3016 9080866 49.47 µM -0.195100402678488 0.425043190367319 no 1933 0.422657173671452 2780 17066299 SGTC_2568 diosmetin 100 µM -0.195386273026895 0.424935679373322 no 1934 0.422545281028802 2802 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_542 3381-0244 89.3 µM -0.195386625224016 0.424935546921394 no 1935 0.42254514317902 2936 1112843 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.196653010284046 0.424459348243553 no 1936 0.422049542148364 2785 279621 SGTC_926 2268-1401 59.4 µM -0.196933434579223 0.424353915201663 no 1937 0.421939814488819 2745 2931578 SGTC_919 tnp00227 403.569 nM -0.197889365121888 0.423994548171936 no 1938 0.421565812522063 2795 1269246 A methoxyflavone. YNL221C POP1 SGTC_2650 prasterone 100 µM -0.19925826093858 0.423480043461461 no 1939 0.421030363690429 2759 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_70 0141-0289 43.283 µM -0.199562269367757 0.423365798405059 no 1940 0.420911469414012 2859 352408 SGTC_2081 5214970 32.255 µM -0.203610011540568 0.421845291973854 no 1941 0.419329134478695 2836 2063512 SGTC_2674 ligustilide 100 µM -0.203819012769144 0.421766813522707 no 1942 0.41924746733246 2862 5319022 A signalling regulator. SGTC_1382 3002-2117 298 µM -0.205098774044755 0.421286340280738 no 1943 0.4187474771226 2894 1497314 SGTC_2452 5863136 48.41 µM -0.207639304637746 0.420332872032458 no 1944 0.417755306240931 2737 2184096 SGTC_86 0417-1630 471.922 µM -0.20804428782868 0.420180923744617 no 1945 0.417597193565185 2775 3634867 SGTC_1420 4'-methoxyflavone 42 µM -0.210768127732176 0.419159258616469 no 1946 0.416534105113626 2800 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2271 7849410 118.62 µM -0.210990521263367 0.419075866624661 no 1947 0.416447333902668 2755 972430 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.211131219165585 0.419023110320349 no 1948 0.416392439950864 2773 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_390 dec-rvkr-cmk 16.7 µM -0.212058486854618 0.418675457046485 no 1949 0.416030702912418 2828 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_840 0245-0196 390 µM -0.212608269019236 0.418469361460369 no 1950 0.415816260579393 2913 3827528 SGTC_1238 0333-0287 48.8 µM -0.21269613703057 0.418436424652131 no 1951 0.415781990015023 2778 7226 SGTC_2855 9016525 58.44 µM -0.212750707936526 0.418415969356235 no 1952 0.41576070641717 2747 43811474 SGTC_369 0957-0393 4.5 µM -0.212940754737497 0.418344734153445 no 1953 0.41568658680452 2856 6997992 SGTC_2877 9040724 71.43 µM -0.21297140378138 0.418333246229435 no 1954 0.415674633738836 2986 6463895 SGTC_1228 0124-0032 52.5 µM -0.213051164150574 0.418303350645903 no 1955 0.415643527720457 2856 X1228 SGTC_1554 st069299 38.7 µM -0.213623514406237 0.418088837598844 no 1956 0.415420330409521 2861 24207999 SGTC_3317 9138495 8.753 µM -0.213844859804041 0.418005885354212 no 1957 0.415334020477299 2793 17020139 SGTC_2923 7992654 58.14 µM -0.214679184898098 0.417693243318883 no 1958 0.415008726129023 2831 2985126 SGTC_3189 9110682 49.47 µM -0.21481918557985 0.417640786727698 no 1959 0.414954147076703 2890 17122418 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.215099897438812 0.417535611747185 no 1960 0.414844716932662 2780 2724278 An inhibitor of dopamine biosynthesis. SGTC_27 0485-0001 32.618 µM -0.215472754445743 0.417395921647529 no 1961 0.414699375984792 2752 2054479 SGTC_14 0354-0009 295 µM -0.216435972795018 0.417035102195534 no 1962 0.414323964239504 2752 1713507 SGTC_608 k048-0125 159 µM -0.217322917635506 0.416702916409957 no 1963 0.413978349086157 2892 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1086 cerivastatin 2.18 µM -0.219273521077261 0.415972570099324 no 1964 0.413218493558119 2776 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1051 3253-3903 78 µM -0.220531053620352 0.415501877514558 no 1965 0.4127287951652 2750 5509239 SGTC_1343 1487-0095 224 µM -0.220808406761599 0.415398080933838 no 1966 0.412620808745986 2847 4560101 YGL055W OLE1 SGTC_1313 1220-0047 237 µM -0.220953072651868 0.415343943544002 no 1967 0.412564486240696 2838 3528706 SGTC_1443 4112-3303 14 µM -0.221424499721545 0.415167535567212 no 1968 0.412380958903805 2805 704433 SGTC_2795 7780010 54.55 µM -0.221495108643903 0.415141115184995 no 1969 0.412353472382238 2927 953673 SGTC_394 menadione 8.33 µM -0.222616010253256 0.41472174871844 no 1970 0.411917187368907 2846 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_725 1497-0963 19 µM -0.222777532117085 0.414661326031367 no 1971 0.411854327681843 2926 3549977 SGTC_69 0096-0274 206.684 µM -0.224478381216745 0.414025189045714 no 1972 0.411192543497988 3095 6741392 SGTC_3112 9123419 49.47 µM -0.224980564455271 0.413837409826411 no 1973 0.410997197006949 2781 17015854 SGTC_1484 3473-2379 286 µM -0.225083386381865 0.413798964493784 no 1974 0.410957202568911 2798 671917 SGTC_2259 7964009 200 µM -0.227394778455638 0.412934948895914 no 1975 0.410058390070639 2957 313134 SGTC_317 4495-0002 170 µM -0.227621356367155 0.412850275004464 no 1976 0.409970307879361 2858 15991618 SGTC_114 0364-0001 490.298 µM -0.227900812611308 0.4127458456622 no 1977 0.409861675486719 2864 4003655 SGTC_431 k089-0097 107 µM -0.229194492420713 0.412262494090527 no 1978 0.409358876536969 2925 5499420 SGTC_1090 efavirenz 20.7 µM -0.229664452179291 0.412086938118377 no 1979 0.409176259806477 2857 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_654 1124-0271 80.9 µM -0.230480585661072 0.411782108927759 no 1980 0.408859173917371 2834 5403748 SGTC_2871 9038510 12.99 µM -0.232023935801089 0.41120580699483 no 1981 0.408259711479333 2964 4945164 SGTC_1312 1218-2183 165 µM -0.232462759946757 0.411041980719945 no 1982 0.408089304132895 2795 6744073 SGTC_3356 9151811 4.48 µM -0.233846649607766 0.410525434751934 no 1983 0.407552016144792 2816 1859254 YPR165W RHO1 SGTC_2239 6685329 187.64 µM -0.233893620484263 0.410507905279221 no 1984 0.40753378299039 2957 805680 SGTC_1346 1488-2224 62.4 µM -0.234739215442734 0.410192360903516 no 1985 0.407205574246834 2877 3722427 SGTC_2187 6125751 200 µM -0.236013589584054 0.409716922084495 no 1986 0.406711062530058 2855 874498 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.236284584648381 0.409615837331374 no 1987 0.406605923993519 2787 5355888 SGTC_228 caffeine 993.056 µM -0.240990277273509 0.407861515140984 no 1988 0.404781326050428 2960 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1695 st026914 34.495 µM -0.241344549831743 0.407729513596238 no 1989 0.404644042684165 2803 3289191 SGTC_2155 5570423 76 µM -0.242636952659436 0.407248054710128 no 1990 0.404143326189843 2847 797402 SGTC_1301 naphtanilide LB 4.81 µM -0.243041103145195 0.407097525232167 no 1991 0.403986778081897 2964 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3256 9138902 49.47 µM -0.24549732878768 0.406182977807188 no 1992 0.403035688111177 2825 17228773 SGTC_2863 9028737 58.44 µM -0.247131785805803 0.405574689687629 no 1993 0.402403117494786 2949 6460917 SGTC_179 1273-0063 6.77 µM -0.247602332448654 0.405399610771143 no 1994 0.402221052940891 2845 3108139 SGTC_1644 st010134 20.9 µM -0.249047511825823 0.404862013285836 no 1995 0.401662014923239 2898 3818134 SGTC_1951 sophoraflavanone G 9.2 µM -0.249859443940852 0.404560058423459 no 1996 0.401348023818482 2832 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_108 0509-0257 621.132 µM -0.251199866489846 0.40406168416119 no 1997 0.400829793890148 2941 536624 SGTC_2790 5423970 71.43 µM -0.251957842596367 0.403779934580653 no 1998 0.400536824730076 3029 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_234 nsc-17383 10.7 µM -0.252077595788416 0.403735425323781 no 1999 0.400490543434663 3002 408974 SGTC_629 3448-6466 76.7 µM -0.252803716605295 0.403465571149048 no 2000 0.400209947769472 2888 573744 SGTC_305 1682-2595 20.8 µM -0.253193965967809 0.403320558587666 no 2001 0.400059164548915 2916 226033 SGTC_1650 st011916 45.8 µM -0.25633867895249 0.402152503073523 no 2002 0.398844666616412 2964 242528 SGTC_2224 6650123 117.647 µM -0.256365138413095 0.402142678802031 no 2003 0.398834452026422 2858 2908370 SGTC_9 0092-0002 10.449 µM -0.257287227897213 0.40180035003401 no 2004 0.398478525663856 2900 759368 SGTC_2025 5147754 141 µM -0.257385479016082 0.401763878417991 no 2005 0.398440605723455 2945 315777 YLR208W SEC13 SGTC_1874 staurosporine 7.6 µM -0.258979142354992 0.401172417302049 no 2006 0.39782566680266 2987 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1266 0828-0227 32.9 µM -0.259665966672119 0.400917583840917 no 2007 0.397560723489729 2982 3913820 SGTC_395 anisomycin 6.25 µM -0.260304216064157 0.400680810992391 no 2008 0.39731456036356 2921 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1053 3366-3204 134 µM -0.26149534075677 0.40023903436416 no 2009 0.396855271050066 2920 3632071 YPR165W RHO1 SGTC_399 oxolinic acid 75 µM -0.261774694588152 0.400135443184049 no 2010 0.396747574859399 2860 4628 A DNA gyrase inhibitor. SGTC_967 1306-0166 352 µM -0.262923415828295 0.399709543395939 no 2011 0.396304803933157 3024 4437607 SGTC_603 3794-0023 45.9 µM -0.263204500874253 0.399605346476053 no 2012 0.396196480942436 2973 3802260 SGTC_3110 9122132 49.47 µM -0.265806123421694 0.398641277348136 no 2013 0.395194263506028 3038 918317 SGTC_534 k292-0788 63.4 µM -0.266040070438173 0.398554615080374 no 2014 0.395104174459924 3031 4146317 SGTC_1257 0669-0121 16 µM -0.266179920428913 0.398502812075087 no 2015 0.395050323267078 2973 4307855 SGTC_1570 verbenone 133 µM -0.266458835277355 0.398399502233195 no 2016 0.394942929194458 3067 29025 A natural terpanoid with antifungal properties. SGTC_1757 st041620 31.8375 µM -0.267181603227507 0.398131822699318 no 2017 0.394664669968031 2946 5289815 SGTC_2334 9017922 200 µM -0.26745244277187 0.398031528706089 no 2018 0.394560412986572 3027 3163164 SGTC_1920 st075728 45.7 µM -0.267805362462732 0.397900849905465 no 2019 0.394424571403881 3083 3400306 SGTC_1287 0971-0001 34.6 µM -0.26881184160043 0.397528234629387 no 2020 0.394037240184138 2903 4665869 SGTC_3239 9133757 49.47 µM -0.269048615293828 0.397440590649545 no 2021 0.393946135926822 2860 17036923 SGTC_2478 5763493 32.33 µM -0.271035459441195 0.396705346268474 no 2022 0.393181879961148 2870 1365576 YLR208W SEC13 SGTC_935 2996-0153 430 µM -0.271254796560463 0.396624201617264 no 2023 0.393097535298704 3057 23738523 SGTC_778 3456-2434 196 µM -0.271555272074159 0.396513046757834 no 2024 0.392981997541073 3036 5539063 SGTC_1972 st070201 17.4 µM -0.272154433771981 0.396291424079031 no 2025 0.392751638202725 3027 2829099 SGTC_1790 st045711 43.5 µM -0.272218618258656 0.396267684998096 no 2026 0.392726963457622 3048 585119 SGTC_1581 himbacine 57.9 µM -0.274536258228631 0.395410747999598 no 2027 0.391836271767825 2883 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3045 9092950 49.47 µM -0.274541103736389 0.395408956922884 no 2028 0.391834410183778 3011 44120432 SGTC_1810 st050138 53 µM -0.275309339984447 0.395125016701622 no 2029 0.391539294683595 3001 3444541 SGTC_987 1497-1013 404 µM -0.276556875018089 0.394664046266949 no 2030 0.39106019112224 2878 1676435 SGTC_699 0375-0592 111 µM -0.277152321767614 0.394444077657102 no 2031 0.390831573878106 2997 762578 SGTC_2119 5528445 120.635 µM -0.277283130643522 0.394395759040455 no 2032 0.390781355858047 3028 791935 SGTC_1539 benzyladenosine 56 µM -0.277642937478491 0.394262860781666 no 2033 0.390643234057009 2890 92208 A nucleotide analog. SGTC_990 3985-0011 41.3 µM -0.278057069201227 0.394109912318877 no 2034 0.390484275226337 2941 5399565 YGL099W LSG1 SGTC_3241 9133421 49.47 µM -0.278726667210642 0.393862648777468 no 2035 0.39022729786835 2935 17018221 SGTC_1131 3454-3128 32.3 µM -0.279120048054141 0.393717404340043 no 2036 0.39007634909179 3050 710982 SGTC_1063 disulfiram 1.84 µM -0.280370947721042 0.393255644362537 no 2037 0.389596461957269 2896 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_597 k018-0003 82.8 µM -0.280446834752726 0.393227636072798 no 2038 0.389567354549546 3020 6786234 SGTC_357 1325-0123 420 µM -0.281472341611236 0.392849197546976 no 2039 0.389174069546828 3034 1098503 SGTC_871 0574-0004 149 µM -0.281641402747455 0.392786819333225 no 2040 0.389109244974645 2899 9551173 SGTC_1247 0448-0043 5.84 µM -0.28170060726951 0.392764975387449 no 2041 0.389086544402832 3021 3089013 YGL099W LSG1 SGTC_3225 9130819 49.47 µM -0.282023306413507 0.392645919093497 no 2042 0.388962819716223 3033 4547121 SGTC_48 0382-0018 55 µM -0.282989661045448 0.392289453317818 no 2043 0.388592381247372 3174 762596 SGTC_3314 9135860 59.4275 µM -0.285608130733559 0.391324015621883 no 2044 0.38758913766659 3060 25252478 SGTC_859 0439-0102 54.6 µM -0.28756346062447 0.390603515620308 no 2045 0.38684045904726 3044 610143 SGTC_1064 honokiol 6.76 µM -0.287855634043958 0.390495887735776 no 2046 0.386728624491324 2984 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1857 st056007 79.3 µM -0.28791027694615 0.39047575986809 no 2047 0.386707709995528 2983 619834 SGTC_1719 st032227 49.2 µM -0.289532845887787 0.389878215990421 no 2048 0.386086824154042 2927 3125804 SGTC_187 1488-2104 32.728 µM -0.289620751040246 0.389845850554133 no 2049 0.386053195028415 2978 2852859 SGTC_176 1486-1328 72.834 µM -0.289633053570709 0.389841320996996 no 2050 0.386048488622386 2985 22310231 SGTC_1477 0139-0234 16 µM -0.289718435741805 0.389809885321864 no 2051 0.386015825628304 2919 620880 SGTC_1614 st002383 48.6 µM -0.289915961785094 0.389737163715578 no 2052 0.385940265034497 2975 1947235 SGTC_2567 aureobasidin a 60 nM -0.290762851100318 0.389425414934859 no 2053 0.385616349443099 3163 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_986 1493-0483 84 µM -0.29090955257331 0.389371419818314 no 2054 0.385560247618066 3025 40079 SGTC_2359 9039622 200 µM -0.291094357528463 0.389303403329446 no 2055 0.385489577602921 2890 6463596 SGTC_2584 androsterone 48.74 µM -0.292137277847244 0.388919625637376 no 2056 0.385090832812728 3054 2754130 A steroid. SGTC_1936 st074407 74.3 µM -0.294976436476794 0.387875411554411 no 2057 0.384005940103328 2927 809813 SGTC_3039 9090270 49.47 µM -0.2952172825368 0.387786867967176 no 2058 0.383913950242684 3040 17173750 SGTC_3105 9121040 49.47 µM -0.295322807988893 0.387748074891616 no 2059 0.383873647422654 2871 41448907 SGTC_598 3937-0236 20.2 µM -0.29722570021043 0.387048729725323 no 2060 0.38314710102765 2996 1379313 SGTC_548 1436-0017 110 µM -0.297937317129341 0.386787292473913 no 2061 0.382875502818545 3066 9677137 SGTC_2687 chenodiol 100 µM -0.299452023244482 0.386230983606835 no 2062 0.382297586637624 3027 5702181 A cholesterol synthesis inhibitor. SGTC_2617 dihydrotanshinone i 20.83 µM -0.299616561177952 0.386170567519126 no 2063 0.38223482511354 2937 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_37 0566-0070 1.56 µM -0.299947715233732 0.386048980630077 no 2064 0.382108518740218 3033 1626686 SGTC_3306 9127676 59.7925 µM -0.300169633151191 0.385967507264399 no 2065 0.382023883440556 3013 41905287 SGTC_3352 9151559 45.5865 µM -0.300368896628272 0.385894355374051 no 2066 0.381947892919922 3016 17159339 SGTC_2905 7799065 20.05 µM -0.303283551036177 0.384824817546684 no 2067 0.38083689030237 3116 1296806 SGTC_747 3448-8087 38.7 µM -0.304001412569606 0.384561531037929 no 2068 0.380563407492088 2990 5168703 SGTC_2172 5754775 163.918 µM -0.304780320276118 0.384275915150803 no 2069 0.380266735505549 2929 2263357 SGTC_1196 1588-0294 184 µM -0.305094465888502 0.384160739583638 no 2070 0.380147102990642 2992 6144269 SGTC_2152 5568786 200 µM -0.306107588672087 0.383789366944674 no 2071 0.37976136508463 2953 5399883 SGTC_3217 9129673 49.47 µM -0.306573015377298 0.383618794800986 no 2072 0.379584197888304 3134 17248312 SGTC_3147 9097027 49.47 µM -0.306730105758631 0.383561228540841 no 2073 0.379524406287695 2969 25236841 SGTC_2749 bexarotene 57.39 µM -0.307306685811187 0.383349961019811 no 2074 0.379304973605983 3043 82146 An retinoic acid receptor inhibitor. SGTC_245 methotrexate 289.6 µM -0.307378333805634 0.383323710548696 no 2075 0.37927770879433 3038 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_82 0054-0107 293.755 µM -0.30811173618613 0.38305503660148 no 2076 0.378998655594318 3013 3104697 SGTC_1553 gossypol 38.6 µM -0.308349978288763 0.382967771308503 no 2077 0.378908020116067 2920 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1640 st009078 66.4 µM -0.308710743793776 0.382835638436107 no 2078 0.378770785203634 3075 690618 SGTC_2066 5222451 176 µM -0.308957170251368 0.382745390870546 no 2079 0.378677053558496 2941 2281147 SGTC_1155 4088-0394 48.2 µM -0.309474045865104 0.382556118708532 no 2080 0.378480476096204 2924 2326248 SGTC_1480 1070-0044 41.2 µM -0.309998508588936 0.382364096930053 no 2081 0.378281045251904 3024 3124987 SGTC_2023 5144124 124 µM -0.310038245436128 0.382349549238079 no 2082 0.378265936341424 2948 2830192 SGTC_1682 st012968 530 nM -0.310157177240929 0.382306009200261 no 2083 0.378220716704808 2953 24207270 SGTC_2564 betulinic acid 100 µM -0.310644634179901 0.382127570440651 no 2084 0.378035395779616 3240 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2837 9008476 45.46 µM -0.31216578806833 0.381570897104067 no 2085 0.377457265500343 3141 2992805 SGTC_2606 farnesol 9.78 µM -0.312585975518539 0.381417170666541 no 2086 0.37729761723781 3129 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3324 9138759 60.749 µM -0.312799591775166 0.381339025893045 no 2087 0.377216462774872 3085 45595710 SGTC_3031 9088762 49.47 µM -0.313655648291334 0.381025913170082 no 2088 0.37689129474432 2904 205253 SGTC_2537 larixol 68.93 µM -0.314289977848141 0.380793949910642 no 2089 0.376650404692451 2974 6708759 SGTC_2240 6690706 185.951 µM -0.31448334597892 0.38072324707305 no 2090 0.376576981653814 2867 805876 SGTC_822 1487-0950 154 µM -0.315554284671352 0.380331742810852 no 2091 0.376170420717632 3114 1958375 SGTC_1837 st055472 66.5 µM -0.317087495030891 0.379771458787313 no 2092 0.375588606597057 3135 676091 SGTC_509 pifithrin 175 µM -0.318245774903631 0.379348353564068 no 2093 0.375149256454557 3060 4817 A p53 inhibitor. SGTC_314 1671-0008 2.74 µM -0.319615495307696 0.378848198203373 no 2094 0.374629913255262 2958 3913060 SGTC_956 1185-0240 191 µM -0.320213223871763 0.378630000276949 no 2095 0.374403349678111 2982 1416193 SGTC_874 0599-0792 117 µM -0.320417917442737 0.378555286765879 no 2096 0.374325772404541 3131 765305 SGTC_1904 st060225 78 µM -0.322371037361614 0.377842623244974 no 2097 0.373585811427853 2977 66595 SGTC_162 k030-0015 37.8 µM -0.323836504204445 0.377308169590862 no 2098 0.37303090888601 3054 1809920 YMR134W ERG29 SGTC_3275 9138069 49.47 µM -0.324560125432971 0.377044352535743 no 2099 0.372757004999943 3078 17617007 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.324704338620695 0.376991782299966 no 2100 0.372702425350194 3014 688788 SGTC_1899 st063254 59.6 µM -0.325013866291082 0.376878957443875 no 2101 0.372585288578999 2946 3093813 SGTC_2103 5378138 10 µM -0.325866687113822 0.37656815310125 no 2102 0.372262610481901 2993 244142 SGTC_1120 ficusin 1.78878 µM -0.326616625267551 0.376294909693578 no 2103 0.371978933734032 3118 6199 A DNA cross-linker. SGTC_3313 9133968 57.047 µM -0.327510623030745 0.375969258506737 no 2104 0.371640854799247 2947 1494643 SGTC_29 0299-0004 12.984 µM -0.327519922650043 0.375965871454043 no 2105 0.371637338525609 3024 16871 A napthoquinone isolated from Swertia calycina. SGTC_1261 0712-0010 12.7 µM -0.328399891790285 0.37564541752882 no 2106 0.371304662398121 3169 2840123 SGTC_293 4049-0273 38.5 µM -0.328673706021427 0.375545721465844 no 2107 0.371201165345231 3024 1380311 SGTC_2723 salbutamol 83.58 µM -0.33008312501404 0.375032682066905 no 2108 0.370668576803573 3085 9884233 β2-adrenoceptor agonist SGTC_1274 0865-0114 173 µM -0.331726020367321 0.374434934493635 no 2109 0.370048075396629 3029 870624 SGTC_993 3909-8757 62.7 µM -0.332750903543802 0.374062195858061 no 2110 0.369661160740864 3014 4288324 YLR208W SEC13 SGTC_2433 5607874 27.82 µM -0.333581446068346 0.373760223090633 no 2111 0.369347710469794 2986 2252428 SGTC_764 1951-2361 146 µM -0.334651924282467 0.373371127618384 no 2112 0.368943835559747 3006 5438930 SGTC_2862 9027634 71.43 µM -0.335073404082559 0.373217964301323 no 2113 0.368784857403494 2963 5012562 SGTC_1428 4049-0204 61.7 µM -0.33713171347095 0.372470274786686 no 2114 0.368008805747639 3107 X1428 SGTC_2006 4011487 200 µM -0.3380616224247 0.372132638827389 no 2115 0.367658375260509 3157 45595294 SGTC_1962 st076595 64.5 µM -0.340215607432053 0.371350937145287 no 2116 0.366847082729659 3005 279619 SGTC_623 k072-0108 16.9 µM -0.340977298827829 0.371074638844677 no 2117 0.366560335826913 3067 5382803 SGTC_2909 7941780 10.49 µM -0.34191461399142 0.370734725437381 no 2118 0.366207575684245 3172 1243215 SGTC_2145 5634607 200 µM -0.342002034673473 0.370703027832637 no 2119 0.366174680521756 2999 308662 SGTC_2073 5212005 126 µM -0.34254175584228 0.370507351382838 no 2120 0.365971612890373 2979 691789 SGTC_1838 st055369 84.5 µM -0.343046606952093 0.370324347427003 no 2121 0.365781698938296 2995 676036 SGTC_726 3448-4391 34.2 µM -0.345219006372679 0.369537207618334 no 2122 0.36496486553725 3189 1356692 SGTC_290 2043-6722 48.1 µM -0.345633290355718 0.369387159316202 no 2123 0.364809162040545 3113 773758 YLR208W SEC13 SGTC_166 k072-0058 166.424 µM -0.345638896991525 0.36938512880159 no 2124 0.364807055008857 3138 5846229 SGTC_2763 lisinopril 49.32 µM -0.345805283721723 0.369324871385456 no 2125 0.364744527014717 3041 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_536 3852-0578 10.6 µM -0.347692134706428 0.368641768014555 no 2126 0.364035702081418 3168 2869208 SGTC_59 0330-0160 1.33 µM -0.3484384734631 0.368371682723245 no 2127 0.363755456495029 3054 4293482 SGTC_80 0159-0065 512.242 µM -0.349229196447995 0.368085606598063 no 2128 0.363458624406806 3076 1548079 SGTC_3094 9117742 49.47 µM -0.349727433834701 0.367905386557176 no 2129 0.363271631524252 2961 17149698 SGTC_948 3448-0295 75.3 µM -0.349821881581554 0.367871226647519 no 2130 0.363236188124565 3012 678569 SGTC_2730 imipramine 71.33 µM -0.350047548803981 0.367789611442227 no 2131 0.363151506743152 3053 3696 A tricyclic antidepressant. SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.355081172153122 0.365970700116543 no 2132 0.361264390624352 3138 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1564 D-Arginine 115 µM -0.355490321062391 0.365822984877713 no 2133 0.361111147355536 3067 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2779 methotrexate 400 µM -0.35556318439171 0.36579668107874 no 2134 0.361083859348146 3119 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_444 curcumin 90.4 µM -0.356148782327394 0.365585302043117 no 2135 0.360864573054854 3158 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2563 tomatine 8.54 µM -0.356286307728189 0.365535666412946 no 2136 0.360813081148893 3240 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_329 k048-0121 21.3 µM -0.356674762724999 0.365395477505847 no 2137 0.360667650461169 3100 6832902 SGTC_3151 9099821 49.47 µM -0.357167404889584 0.365217714521505 no 2138 0.360483242920008 3148 17174189 SGTC_759 3486-0358 89.3 µM -0.357499229460015 0.365097996617982 no 2139 0.360359051468343 3216 875103 SGTC_976 1348-1067 47.6 µM -0.35785758275536 0.364968722268637 no 2140 0.36022494769887 3028 5310671 YGL099W LSG1 SGTC_688 0527-0193 473 µM -0.358792292986709 0.364631601986539 no 2141 0.359875239313415 3039 4007154 SGTC_2911 7942208 15.64 µM -0.359009762474865 0.364553182649545 no 2142 0.359793893038029 3111 1243384 SGTC_2477 5967686 25.23 µM -0.361349267648818 0.363709917889336 no 2143 0.358919183960141 2997 776118 SGTC_1457 k015-0032 57.3 µM -0.361757872664586 0.363562705501775 no 2144 0.358766487821221 3022 4302660 SGTC_157 1348-1695 65.819 µM -0.362119464054186 0.363432448002628 no 2145 0.358631379548315 3070 5380510 SGTC_1319 1306-0155 43.7 µM -0.362588167576126 0.363263628573869 no 2146 0.358456275259221 3051 3122360 SGTC_1150 3909-7983 10.9 µM -0.363951912660531 0.362772580808353 no 2147 0.357946959197028 3070 23965914 SGTC_916 4466-0038 42 nM -0.364289848620197 0.36265093404287 no 2148 0.35782078974461 3267 5722064 YGL116W CDC20 SGTC_2762 leflunomide 42.06 µM -0.364506505565241 0.362572951361091 no 2149 0.357739908363261 3032 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2635 hydroquinidine 100 µM -0.364939349599136 0.362417172190156 no 2150 0.357578340135344 3011 442912 An experimental heart treatment. SGTC_2661 dactinomycin 12.96 µM -0.366427095004313 0.361881911254273 no 2151 0.357023202330773 3075 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_383 2324-0395 7.37 µM -0.36667065510409 0.361794308916876 no 2152 0.35693234902747 3175 3146421 SGTC_981 1488-1094 54.9 µM -0.367184538105417 0.361609502110128 no 2153 0.356740685927641 2995 3449522 SGTC_671 0560-0003 407 µM -0.367510536165842 0.361492280752086 no 2154 0.356619117075304 3072 3238678 SGTC_890 0929-0006 47.2 µM -0.368600247389987 0.361100540223047 no 2155 0.356212855573061 3057 1378169 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.368837356942594 0.361015320935048 no 2156 0.356124478996027 3099 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2319 6033012 152.6 µM -0.369062332288759 0.360934469166952 no 2157 0.356040632282347 3050 847246 SGTC_3193 9111931 49.47 µM -0.369126451758036 0.360911427013252 no 2158 0.356016736686155 3026 17087244 SGTC_2529 gangaleoidin 93.61 µM -0.369430924199841 0.360802017827243 no 2159 0.355903275742525 3026 4565183 SGTC_2366 9070441 60.58 µM -0.36998444938924 0.360603143162445 no 2160 0.355697038570023 3050 6837235 SGTC_3278 9139605 49.47 µM -0.37042603082086 0.360444515516632 no 2161 0.355532540646692 3227 7958859 SGTC_2989 9073649 71.4286 µM -0.371087168636172 0.360207062355548 no 2162 0.355286303880744 3143 21367202 SGTC_1362 1611-0397 101 µM -0.371168884240034 0.36017771725703 no 2163 0.35525587359257 3074 27816 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.371384664663894 0.360100231760125 no 2164 0.355175522991088 3041 688803 SGTC_1963 st076565 50.3 µM -0.372573325233966 0.359673493765431 no 2165 0.354733014518864 3067 4914280 SGTC_152 4469-0003 551.229 µM -0.374270028178044 0.3590646678854 no 2166 0.354101714199358 3133 697280 SGTC_805 3852-0218 479 µM -0.374391865894259 0.35902096275417 no 2167 0.354056396865662 3031 6615355 SGTC_1118 chelidonine 707.474 nM -0.37459622823952 0.358947658866325 no 2168 0.353980389276692 3172 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_841 0251-0215 91.2 µM -0.375223179468491 0.35872280659568 no 2169 0.353747246378492 3122 3888614 SGTC_1508 1080-0625 72.9 µM -0.37537899468395 0.35866693200226 no 2170 0.353689312241175 3029 767111 SGTC_20 0481-0013 4.944 µM -0.375483467676521 0.358629470179082 no 2171 0.353650469712142 3104 182045 SGTC_903 1134-0042 114 µM -0.376069880214819 0.358419220199676 no 2172 0.353432472792564 3076 701009 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.377062253232906 0.358063516575634 no 2173 0.353063670948008 3286 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1073 triclabendazole 3.09 µM -0.377968556868914 0.357738771040252 no 2174 0.352726976146705 3148 50248 An antihelmetic and likely tubulin inhibitor. SGTC_777 1315-0167 517 µM -0.379301224420427 0.357261438382796 no 2175 0.352232095258583 3134 4221767 SGTC_1588 farnesol 29.9 µM -0.379501520939678 0.357189715790029 no 2176 0.352157737529015 3068 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2419 paclitaxel 166.5 µM -0.380883431640995 0.356695015957978 no 2177 0.351644873568456 3042 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2932 9016711 44.54 µM -0.381129851551625 0.35660682723483 no 2178 0.351553448888018 3211 7117328 SGTC_1665 st014639 11.4 µM -0.38215500042408 0.356240029422665 no 2179 0.351173198830968 3112 981133 YIL048W NEO1 SGTC_2722 naftopidil 47.16 µM -0.383863879816113 0.355628888853261 no 2180 0.350539669463777 3192 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2922 7999257 32.47 µM -0.384567994275303 0.355377186673823 no 2181 0.350278755311936 3127 2988377 SGTC_3342 9147791 14.508 µM -0.385584111859965 0.355014062885697 no 2182 0.349902350948118 3079 1838168 SGTC_2954 9074818 52.69 µM -0.388620034150445 0.35392991911695 no 2183 0.348778622198899 3240 16648742 SGTC_1432 4049-0298 68.4 µM -0.389081581858173 0.353765201415374 no 2184 0.348607898849302 3186 741646 SGTC_1655 st012546 55.1 µM -0.390092810930398 0.353404408485 no 2185 0.348233959314736 3161 720985 YLR208W SEC13 SGTC_2388 9080168 200 µM -0.391483079380531 0.352908594432832 no 2186 0.347720096708547 3077 15943073 SGTC_3196 9111891 49.47 µM -0.392971606344937 0.352378015029448 no 2187 0.347170226349358 3117 18891510 SGTC_1496 4469-0713 57.4 µM -0.39306236227935 0.352345674721694 no 2188 0.347136710978824 3209 746691 SGTC_531 3788-1495 174 µM -0.393178209202153 0.352304394948757 no 2189 0.347093931463443 3037 2896655 SGTC_3184 9108758 49.47 µM -0.393944176622297 0.352031501323983 no 2190 0.346811126954948 3063 902885 SGTC_360 0957-0399 1.01 µM -0.395447376744118 0.351496173073638 no 2191 0.346256375303692 3230 6752301 YPR165W RHO1 SGTC_2775 cyproheptadine 69.59 µM -0.397075188512685 0.350916799435331 no 2192 0.345656007910221 3209 2913 A selective serotonin reuptake inhibitor. SGTC_3161 9100388 49.47 µM -0.397680900540207 0.350701301710583 no 2193 0.345432708957282 3116 25236368 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.397742038739485 0.350679552881877 no 2194 0.345410173022791 3180 4213774 SGTC_2355 9061122 103.12 µM -0.3984260365351 0.350436266190699 no 2195 0.345158084402197 3187 5302957 SGTC_697 0508-1955 564 µM -0.399878768997054 0.349919756910349 no 2196 0.344622905230538 3266 6243113 SGTC_963 1269-2853 151 µM -0.400468152274309 0.349710284738706 no 2197 0.344405868033721 3096 3668223 SGTC_3108 9121785 49.47 µM -0.400886185381586 0.349561739698785 no 2198 0.34425196065305 3160 17140271 SGTC_670 4204-0025 119 µM -0.401733783797231 0.349260622449282 no 2199 0.343939979260433 3200 719039 SGTC_1938 st074717 56.4 µM -0.402047623425195 0.349149152046315 no 2200 0.343824489079706 3117 17250979 SGTC_2666 tannic acid 100 µM -0.402964359095945 0.348823617961125 no 2201 0.343487222020426 3199 16134267 A thiamine antagonist. SGTC_1235 benzylparaben 21.5 µM -0.403315642719356 0.348698906138825 no 2202 0.343358017771994 3180 7180 SGTC_2455 5377712 9.75 µM -0.40332755022619 0.348694679052293 no 2203 0.34335363843939 3166 2243908 SGTC_1358 1509-0022 2.48 µM -0.404235831185395 0.348372300687613 no 2204 0.343019653677675 3175 3258434 SGTC_1555 citronellol 128 µM -0.40457038203735 0.348253585324662 no 2205 0.342896666584249 3190 8842 A terpine precursor. SGTC_2107 5363541 170.161 µM -0.406296036312564 0.347641473272636 no 2206 0.342262548704668 3223 244052 SGTC_2276 7947513 42.08 µM -0.406689203422035 0.347502067248362 no 2207 0.342118135585854 3168 2105100 SGTC_690 glyoxal 20.3 µM -0.406925978082261 0.347418123546137 no 2208 0.342031177681374 3174 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1469 k284-2957 126 µM -0.407851077243283 0.34709021997705 no 2209 0.341691505947136 3161 23884841 SGTC_563 tetrahydrosecaminediol 614 µM -0.40872653382011 0.346780017733765 no 2210 0.341370179646994 3262 334274 A psychoactive constituent of the cannabis plant. SGTC_2930 9013230 14.89 µM -0.409332293127067 0.346565437944241 no 2211 0.341147909916306 3222 2995857 SGTC_2857 9024691 58.44 µM -0.410125222539959 0.346284630764725 no 2212 0.340857045620076 3200 16478292 SGTC_119 0121-0043 24.815 µM -0.41213500057523 0.345573268821537 no 2213 0.340120237940791 3193 1092378 SGTC_681 1642-0006 26.6 µM -0.412198361669474 0.345550850979256 no 2214 0.340097018943374 3228 4446530 SGTC_3296 9122258 64.045 µM -0.412433226022676 0.345467758149839 no 2215 0.340010956989134 3213 4730474 SGTC_696 1560-0013 611 µM -0.413193315239644 0.345198896697252 no 2216 0.339732492688766 3313 1650269 SGTC_149 3970-0822 46.1 µM -0.413308461179351 0.345158173676871 no 2217 0.339690315746379 3261 3114250 YBL034C STU1 SGTC_244 nsc-207895 1.295 µM -0.414719529698511 0.344659274709205 no 2218 0.339173616945156 3087 42640 SGTC_951 1171-0579 82.7 µM -0.41473997449413 0.344652048207023 no 2219 0.339166132780268 3148 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_651 3253-0966 34.4 µM -0.415056520984722 0.344540167607734 no 2220 0.339050263657071 3146 781462 SGTC_2841 9004761 38.96 µM -0.415258160840227 0.344468906846845 no 2221 0.338976463056518 3148 2991039 SGTC_1050 3232-1156 69.3 µM -0.415372457837535 0.344428516038515 no 2222 0.33893463286502 3171 700529 SGTC_1326 1431-2094 10.8 µM -0.416033962349751 0.344194785332556 no 2223 0.338692575758181 3068 616278 SGTC_91 0417-1751 58.384 µM -0.416420691983171 0.344058168937372 no 2224 0.338551094862526 3226 6795624 SGTC_2198 6589944 200 µM -0.4169828337781 0.343859622609786 no 2225 0.338345481937085 3195 5290268 SGTC_2304 7443016 91.4 µM -0.417121261225514 0.343810737169862 no 2226 0.338294857135609 3109 939854 SGTC_2701 st077767 14.721 µM -0.418152609162154 0.343446600485125 no 2227 0.337917771230165 3167 5721188 SGTC_1980 st071811 45.7 µM -0.418328513216767 0.343384508758584 no 2228 0.337853472647764 3284 4974850 SGTC_484 loperamide 105 µM -0.418723052308582 0.343245257226867 no 2229 0.337709273145454 3152 3955 An opioid-receptor agonist. SGTC_272 doxorubicin 8.13 µM -0.418855611517382 0.343198475578979 no 2230 0.337660829623751 3206 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1108 betulinic acid 729.144 nM -0.41944771008844 0.342989546624655 no 2231 0.337444481125886 3186 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_977 1348-1378 135 µM -0.423997274076562 0.341385784841291 no 2232 0.335783900643939 3109 X977 SGTC_3055 9094636 49.47 µM -0.424855250022776 0.34108366036317 no 2233 0.335471099182722 3329 25236176 SGTC_2490 carminic acid 95.39 µM -0.426141573014096 0.34063089022331 no 2234 0.33500234429979 3243 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2050 5263056 171 µM -0.426360696374272 0.340553784314005 no 2235 0.334922518136624 3286 763468 YGL055W OLE1 SGTC_3149 9097855 49.47 µM -0.426679435920153 0.34044163700258 no 2236 0.334806415328141 3271 25236625 YMR079W SEC14 SGTC_920 mycophenolic acid 780.421 nM -0.426756418679317 0.340414553022858 no 2237 0.334778376259067 3148 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2036 5160441 105 µM -0.428173746136524 0.339916057817397 no 2238 0.334262314469811 3190 134534 YIL048W NEO1 SGTC_1138 3761-0006 1.03 µM -0.428525034451333 0.339792547709933 no 2239 0.334134455589453 3242 12061087 SGTC_749 1000-0129 128 µM -0.429008739614244 0.339622509063347 no 2240 0.333958432268674 3319 708470 SGTC_274 sirtinol 40.1 µM -0.42936871893206 0.339495985396176 no 2241 0.333827457256399 3192 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3312 9133330 71.43 µM -0.430463034778261 0.339111472050984 no 2242 0.333429425319899 3287 17617324 SGTC_2587 piperic acid 92.2 µM -0.430524170424073 0.339089995555933 no 2243 0.333407194175803 3177 5370536 SGTC_914 3820-6779 408 µM -0.431545839357623 0.338731168329767 no 2244 0.333035764843978 3117 2893481 SGTC_3138 9097216 49.47 µM -0.431815679900863 0.338636420228082 no 2245 0.332937691213384 3233 25237486 SGTC_570 0987-0065 62.6 µM -0.431877140791498 0.338614841122801 no 2246 0.332915354830834 3164 3104428 SGTC_1373 2887-0003 58.5 µM -0.432502701320131 0.338395235072162 no 2247 0.332688044658393 3199 776948 SGTC_3219 9131112 49.47 µM -0.433205037081688 0.338148742189143 no 2248 0.332432909918703 3256 17612988 YMR079W SEC14 SGTC_1421 4029-0249 71.4 µM -0.4354523069643 0.337360503233234 no 2249 0.331617075047032 3313 2894095 SGTC_2406 ethylparaben 405.7 µM -0.436026806487359 0.33715910955089 no 2250 0.331408640255451 3038 8434 A possible steroid mimic. SGTC_1391 3442-0225 151 µM -0.436166987562255 0.337109975452933 no 2251 0.331357788929731 3133 5227075 SGTC_1911 st060208 74.3 µM -0.436662055188672 0.336936474260111 no 2252 0.331178225769511 3250 688783 SGTC_2112 5488546 200 µM -0.437126316043742 0.336773801112359 no 2253 0.331009871622812 3157 600757 SGTC_550 4123-0385 25.7 µM -0.438129754404383 0.336422308990408 no 2254 0.330646113180891 3169 5731123 SGTC_226 1,3-diallylurea 8.28947 mM -0.438153942368429 0.336413838006686 no 2255 0.330637346726089 3243 74537 YKL182W FAS1 SGTC_591 4299-0174 154 µM -0.438346365745512 0.336346451444496 no 2256 0.330567609943896 3195 5509088 SGTC_2267 7931562 200 µM -0.438893678499266 0.336154811562734 no 2257 0.33036928871272 3113 934880 SGTC_2620 irigenin 100 µM -0.439800191539782 0.335837492476199 no 2258 0.330040914454138 3329 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_432 NS 1619 61.3 µM -0.443736336811427 0.334461029382687 no 2259 0.328616610509377 3312 4552 A K+/calcium channel activator. SGTC_1634 st006576 41 µM -0.444169302495537 0.334309757385956 no 2260 0.328460092218014 3353 3915356 SGTC_1101 ebselen 5.29 µM -0.444460963802099 0.334207870275248 no 2261 0.328354672814292 3324 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_89 0302-0250 142.109 µM -0.445112412600297 0.333980341404583 no 2262 0.328119259522851 3270 4203518 YLR208W SEC13 SGTC_2254 7938975 95.19 µM -0.445321227113404 0.333907422518305 no 2263 0.32804381490733 3361 2969277 SGTC_1280 0880-0253 10.1 µM -0.448066958287664 0.332949186156261 no 2264 0.327052436710098 3194 6836607 SGTC_2835 9006588 71.43 µM -0.448251282946806 0.332884897419519 no 2265 0.326985927740375 3352 2345538 SGTC_31 0508-1974 57.237 µM -0.448568426967009 0.332774295457025 no 2266 0.326871507068876 3279 6810525 SGTC_2630 antimycin a 100 µM -0.450800431574676 0.331996310059738 no 2267 0.326066695120122 3163 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_923 1900-2434 73.3 µM -0.450991705381066 0.331929673465373 no 2268 0.325997763584399 3184 5910570 SGTC_2269 7935389 174.42 µM -0.453810442517179 0.330948289957395 no 2269 0.324982633467551 3253 97605 SGTC_2446 5162541 200 µM -0.454476182669923 0.330716672197234 no 2270 0.324743065345391 3167 1549321 SGTC_1866 st057638 64 µM -0.456910792684186 0.3298701990073 no 2271 0.323867583112342 3217 688802 SGTC_839 0122-0028 230 µM -0.458676741534611 0.329256752510444 no 2272 0.323233159293735 3210 759448 SGTC_2755 lomerizine 42.69 µM -0.458923109598892 0.329171206880258 no 2273 0.323144691427476 3216 3949 A calcium channel blocker. SGTC_711 k292-0785 179 µM -0.459668777851067 0.328912345287437 no 2274 0.322876991717892 3212 4146315 SGTC_1328 1441-0025 69.2 µM -0.460547477735481 0.328607406558132 no 2275 0.322561650555561 3227 4562601 SGTC_2264 7948757 110.76 µM -0.461003646668012 0.328449145411245 no 2276 0.322397994401118 3132 2971411 SGTC_1422 4031-0024 15.5 µM -0.462279387981148 0.328006709052285 no 2277 0.321940489462763 3253 782427 SGTC_3159 9100096 49.47 µM -0.462919392914309 0.327784841517804 no 2278 0.321711073166744 3188 25236875 SGTC_2656 pseudo-anisatin 100 µM -0.463217425999382 0.327681544510378 no 2279 0.321604263355055 3245 6708809 A neurotoxin. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.464839897467398 0.327119434220605 no 2280 0.321023056954379 3231 91467 include heat shock SGTC_32 0928-0142 34.1 µM -0.465218950468708 0.326988166559942 no 2281 0.320887334595537 3293 2244242 SGTC_864 0469-0573 172 µM -0.465902756181453 0.326751415885823 no 2282 0.320642554110606 3223 689425 SGTC_2499 avocadenofuran 51.48 µM -0.465962042887407 0.326730892626483 no 2283 0.32062133504573 3182 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3003 9075612 71.4286 µM -0.467847306612087 0.326078545188489 no 2284 0.319946893937277 3270 6501993 SGTC_1958 st076513 41.9 µM -0.467909079212917 0.32605717934427 no 2285 0.319924805232566 3203 732122 YGL099W LSG1 SGTC_182 3448-4371 550.524 µM -0.468394519027336 0.325889295796891 no 2286 0.319751243434725 3342 3491403 SGTC_2918 7977171 22.06 µM -0.46853621196464 0.325840299644149 no 2287 0.319700590667186 3257 2236483 SGTC_480 am 92016 50 µM -0.469529006348766 0.325497084614612 no 2288 0.319345778260545 3273 2129 K+ channel blocker. SGTC_482 fipronil 114 µM -0.470659917807254 0.325106301889698 no 2289 0.318941806001184 3298 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2348 9022543 33.42 µM -0.4708489484025 0.325041001737199 no 2290 0.318874303444156 3316 3162678 YDL140C RPO21 SGTC_3191 9110352 49.47 µM -0.473173015984408 0.324238598044386 no 2291 0.318044873785976 3305 17122424 SGTC_2310 7668677 200 µM -0.474384345175111 0.323820699635449 no 2292 0.317612927241614 3419 2197143 SGTC_333 3486-0131 40.1 µM -0.474673905600649 0.323720836574706 no 2293 0.317509709937172 3375 6744690 SGTC_944 3370-0224 231 µM -0.474758755956219 0.323691575945901 no 2294 0.317479466692242 3257 4580514 SGTC_2994 9053520 71.4286 µM -0.475163184112737 0.323552123953657 no 2295 0.317335332953456 3337 4647384 SGTC_1214 0358-0031 63.7 µM -0.475334919573615 0.323492914867254 no 2296 0.317274136703654 3412 4301366 SGTC_2610 ononetin 44.17 µM -0.476673218884533 0.32303166377296 no 2297 0.316797418099685 3294 259632 SGTC_224 benfluorex 43.875 µM -0.476691427997751 0.323025389791371 no 2298 0.316790933885456 3339 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1233 0325-0408 14.2 µM -0.478846147825797 0.322283333262122 no 2299 0.316024042030444 3346 12874 SGTC_1816 st051957 91.6 µM -0.482568975898665 0.321002910114774 no 2300 0.314700905924173 3293 674121 SGTC_2526 patulin 37.61 µM -0.482707615325823 0.320955267668807 no 2301 0.314651677650947 3364 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_111 0083-0039 52.457 µM -0.486009951807483 0.319821316221823 no 2302 0.313480055027003 3272 759313 SGTC_1188 1403-0014 4.57 µM -0.4872919827797 0.31938154689882 no 2303 0.313025714203467 3274 9614867 SGTC_2685 mycophenolic acid 18.85 µM -0.487364386850649 0.319356718026253 no 2304 0.313000063278985 3283 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_160 3453-0671 289.699 µM -0.489322670792119 0.318685488972284 no 2305 0.312306636624563 3265 5322268 SGTC_2858 9025781 8.96 µM -0.490113256125229 0.318414673168628 no 2306 0.312026879111207 3369 4894980 YPL153C RAD53 SGTC_1987 st072290 61.9 µM -0.490948293203027 0.318128735707619 no 2307 0.311731509540979 3279 54697379 SGTC_2833 9001315 45.46 µM -0.491523996043397 0.317931663832239 no 2308 0.311527942252353 3201 2989378 SGTC_260 nsc-65238 3.989 µM -0.492188451502398 0.317704274664896 no 2309 0.311293063830376 3336 3246252 SGTC_1525 8-methoxypsoralen 92.5 µM -0.492448222188412 0.317615394931884 no 2310 0.31120125834428 3450 4114 Related to psoralen; DNA damaging agent. SGTC_1211 1056-0033 32.3 µM -0.492544541716825 0.317582442175458 no 2311 0.311167221070598 3374 6741922 SGTC_289 k017-0060 526 µM -0.493052657991831 0.317408629788226 no 2312 0.310987690314245 3267 5512909 SGTC_1813 st051246 8.6015 µM -0.493628058899204 0.317211849809568 no 2313 0.310784440439985 3325 5291959 SGTC_2728 chlorpromazine 9.18 µM -0.493690872917252 0.317190371320963 no 2314 0.310762256027578 3298 2726 A thorazine and dopamine antagonist. SGTC_879 0831-1030 162 µM -0.49579439037932 0.316471455097266 no 2315 0.310019741529734 3349 1549252 SGTC_803 4488-1585 147 µM -0.495953723300947 0.316417028304987 no 2316 0.309963530568043 3355 747204 SGTC_2139 5578692 56.4705 µM -0.496107336581713 0.316364559058533 no 2317 0.309909341640265 3326 650991 YMR113W FOL3 SGTC_1862 st057513 3.81 µM -0.496562736446175 0.316209031163141 no 2318 0.309748718145892 3232 5393163 SGTC_1731 st035964 63 µM -0.496822641581971 0.316120283083469 no 2319 0.309657063620209 3258 6739575 SGTC_2234 tolnaftate 200 µM -0.497587505944938 0.315859171407779 no 2320 0.309387405881475 3302 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3116 9124943 49.47 µM -0.498657794016429 0.315493947494216 no 2321 0.30901024137061 3282 41905195 YPL160W CDC60 SGTC_1322 1348-1070 12 µM -0.49920034017476 0.315308878434279 no 2322 0.308819127483706 3369 6758089 SGTC_1526 st051518 75 µM -0.500343422974911 0.314919110744404 no 2323 0.308416641786477 3269 673993 SGTC_2968 9090663 33.37 µM -0.500365987119392 0.314911418908288 no 2324 0.30840869914285 3266 25236811 SGTC_2440 5628896 157.78 µM -0.500456821783595 0.314880455313529 no 2325 0.308376725987456 3265 5522048 SGTC_2731 amoxapine 43.43 µM -0.50165380332967 0.31447255151552 no 2326 0.30795553284566 3362 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2297 7971671 152.32 µM -0.50176368318274 0.314435118324461 no 2327 0.307916881052881 3406 909016 SGTC_1929 genistein trimethyl ether 50.5 µM -0.502305047386035 0.31425071756586 no 2328 0.307726479655424 3437 136420 SGTC_2235 salicylic acid 500 µM -0.502451877599475 0.314200711898984 no 2329 0.307674847413803 3353 338 A COX inhibitor and kinase inhibitor. SGTC_201 4262-0159 12.803 µM -0.502749128938024 0.314099488056863 no 2330 0.307570331863217 3293 1341029 SGTC_2626 ethyl orsellinate 100 µM -0.503257603858159 0.313926368069906 no 2331 0.307391584906075 3267 75653 A natural product. SGTC_3247 9135149 49.47 µM -0.505235925415694 0.313253200621549 no 2332 0.306696570195708 3310 8934436 YOR116C RPO31 SGTC_2153 5569715 200 µM -0.506157958708901 0.312939670788055 no 2333 0.306372882847739 3343 2054701 SGTC_1438 4092-1045 4 µM -0.506460523673704 0.312836815521834 no 2334 0.306266697837301 3299 1351342 SGTC_441 propafenone 146 µM -0.506599801618365 0.31278947366044 no 2335 0.306217823786272 3273 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_612 0302-0167 22.4 µM -0.507080425563006 0.312626128853277 no 2336 0.306049194429082 3333 235821 SGTC_3282 9108498 15.4605 µM -0.50756789832234 0.312460493994739 no 2337 0.305878204105547 3346 16459645 SGTC_1703 st026983 48.3 µM -0.508528955064334 0.312134054426986 no 2338 0.305541219149591 3409 1104023 SGTC_1916 st067606 49.2 µM -0.508538583046454 0.312130784861701 no 2339 0.305537844026373 3322 19590279 SGTC_3078 9116413 49.47 µM -0.508763102129836 0.312054544649834 no 2340 0.305459142753195 3275 17177322 SGTC_3208 9114115 49.47 µM -0.50951109631727 0.311800605472036 no 2341 0.305197011232877 3324 650895 SGTC_2464 5717415 7.67 µM -0.511997968495339 0.3109569720844 no 2342 0.304326215676354 3284 5285744 SGTC_326 k292-0812 17.5 µM -0.512433327190827 0.310809385264092 no 2343 0.304173885663482 3347 3579357 SGTC_686 1319-0111 510 µM -0.512761179759675 0.310698263162251 no 2344 0.304059193980153 3440 4562600 SGTC_1624 st003710 6.25 µM -0.513288824346364 0.310519459964059 no 2345 0.303874650138818 3384 24207033 SGTC_2543 pimpinellin 60.67 µM -0.51414498782122 0.310229426645211 no 2346 0.303575313073347 3252 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2322 7413319 38.22 µM -0.516470482042555 0.309442239809266 no 2347 0.302762925011882 3401 1840400 SGTC_1730 st033808 45.1 µM -0.516651122410236 0.309381129018195 no 2348 0.302699860886595 3262 1045166 SGTC_216 k038-0035 28.382 µM -0.519716425196681 0.308344939284407 no 2349 0.30163061852798 3371 4444231 YPR107C YTH1 SGTC_958 1222-0007 33 µM -0.51999624881729 0.308250424028079 no 2350 0.301533094807329 3455 7312461 SGTC_1418 3966-3099 2.4 µM -0.520007636268171 0.308246577989176 no 2351 0.301529126369967 3399 740335 SGTC_2793 7325131 81.82 µM -0.520360790859159 0.308127312729852 no 2352 0.301406066430321 3304 4176441 SGTC_2003 4023581 200 µM -0.520457856885776 0.308094535719554 no 2353 0.301372246848856 3405 16641307 SGTC_1907 st060210 83.7 µM -0.521273911284199 0.307819033077653 no 2354 0.301087986133333 3453 688793 SGTC_1158 4092-0494 91.8 µM -0.521998224531395 0.307574593269847 no 2355 0.300835783385758 3435 1148199 SGTC_2135 5326629 150.42 µM -0.522302650179213 0.307471881789146 no 2356 0.300729812138634 3307 5020077 SGTC_831 k061-1017 217 µM -0.523512429231004 0.307063858464632 no 2357 0.300308851937522 3387 1240153 SGTC_2979 9012552 45.46 µM -0.525158320243897 0.306509130739486 no 2358 0.299736568288658 3441 17100905 SGTC_2298 7976326 193.81 µM -0.525331797649802 0.306450688059957 no 2359 0.299676278204675 3337 2235818 SGTC_3236 9132701 49.47 µM -0.525924897611901 0.306250916228555 no 2360 0.299470194621264 3376 24282524 SGTC_3344 9148862 3.898 µM -0.526764013048003 0.305968378229685 no 2361 0.299178738202591 3457 4905352 SGTC_1825 st052143 62.6 µM -0.527033704072208 0.305877595244406 no 2362 0.29908509168808 3448 674173 SGTC_3250 9135583 49.47 µM -0.528408342270728 0.305415052013938 no 2363 0.298607974318726 3424 7699353 SGTC_94 0334-0113 514.748 µM -0.528478826850481 0.305391343469315 no 2364 0.29858351945517 3366 6795178 SGTC_2280 7785178 200 µM -0.528682461870796 0.305322852364536 no 2365 0.298512872713261 3328 2954328 SGTC_1370 2001-0092 44.6 µM -0.52885944599646 0.305263330622649 no 2366 0.298451478097015 3503 790957 SGTC_2931 9014674 55.67 µM -0.529134663917482 0.305170781985704 no 2367 0.298356018246429 3293 2996810 SGTC_2556 citropten 84.59 µM -0.530058895734823 0.304860078013702 no 2368 0.298035548463357 3336 2775 A potential DNA crosslinker. SGTC_1849 st056239 19.2 µM -0.530067757690516 0.304857099522971 no 2369 0.298032476412486 3299 5393181 SGTC_3240 9133527 49.47 µM -0.530376873347315 0.304753214282946 no 2370 0.29792532862074 3358 17617455 SGTC_3266 9136860 49.47 µM -0.531023346026435 0.304536003549574 no 2371 0.297701300610731 3374 4871271 YPR165W RHO1 SGTC_1032 k061-1018 98.7 µM -0.532942964127919 0.303891430330069 no 2372 0.297036531447239 3478 4005393 SGTC_1225 1216-0074 20.6 µM -0.53332754817637 0.303762367122939 no 2373 0.29690343058303 3351 4241466 SGTC_2316 5844804 197.44 µM -0.535129471675987 0.30315798263813 no 2374 0.296280165885668 3397 776813 SGTC_2582 agaric acid 100 µM -0.53642411267459 0.30272407844025 no 2375 0.295832735149584 3410 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_572 0960-0087 17.7 µM -0.536437757334972 0.30271950685854 no 2376 0.295828021178564 3362 6796365 SGTC_2583 asiatic acid 100 µM -0.537885313737497 0.302234685426437 no 2377 0.295328114058541 3478 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_900 1112-0045 141 µM -0.537918377654823 0.302223615597169 no 2378 0.295316700125043 3371 56211 YIL048W NEO1 SGTC_2942 9052777 62.25 µM -0.540158244461818 0.301474130285707 no 2379 0.294543953008164 3432 6469503 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.540636073808456 0.301314351379226 no 2380 0.294379224194439 3378 4620898 SGTC_1454 4239-0054 42.6 µM -0.542022562217062 0.300850946620854 no 2381 0.293901481543794 3527 1340767 SGTC_2125 5246583 200 µM -0.542830416891601 0.30058108639645 no 2382 0.293623284296867 3505 835267 SGTC_745 0469-0705 296 µM -0.54299514208369 0.300526074103532 no 2383 0.293566573596844 3542 3486736 SGTC_641 4092-0595 30 µM -0.54374919089322 0.300274306972694 no 2384 0.293307038512182 3441 786260 SGTC_1339 1486-1321 22.7 µM -0.543963756757731 0.300202683637623 no 2385 0.293233206804311 3374 3469382 SGTC_2704 st078022 71.1 µM -0.544218077261743 0.30011779997744 no 2386 0.293145706759953 3472 54697681 SGTC_1008 4106-0037 6 µM -0.54890482175382 0.298555469133873 no 2387 0.291535384501963 3430 2905394 SGTC_1284 0929-0043 16 µM -0.549072324155311 0.298499700574573 no 2388 0.291477908648043 3389 1239883 SGTC_2013 4024628 200 µM -0.54912853407132 0.298480987003304 no 2389 0.291458622270714 3477 5230760 SGTC_328 k915-0120 63.5 µM -0.549730967784959 0.29828045651804 no 2390 0.291251956558489 3436 6624543 SGTC_302 1094-0063 18.9 µM -0.549913899353563 0.298219576723714 no 2391 0.291189215175077 3351 5440289 SGTC_134 0269-0018 6.916 µM -0.550304423200736 0.298089628966885 no 2392 0.291055295463449 3382 4378915 SGTC_1017 4239-0030 168 µM -0.550470872629316 0.298034250358649 no 2393 0.2909982248282 3355 1149593 SGTC_3330 9141424 71.43 µM -0.553055589964658 0.297174903557526 no 2394 0.290112672655499 3445 27261020 SGTC_366 0181-0206 4.31 µM -0.553838447120983 0.296914848938663 no 2395 0.289844706711983 3523 274874 SGTC_1187 1391-0724 117 µM -0.553867613928412 0.296905162129788 no 2396 0.289834725383381 3436 6997986 SGTC_1569 carminic acid 40.6 µM -0.554227575701467 0.296785624411533 no 2397 0.289711554223201 3467 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_522 1273-0010 11.6 µM -0.556235055138826 0.296119376062669 no 2398 0.289025088944474 3518 5705015 SGTC_2552 juarezic acid 87.02 µM -0.556698072973017 0.295965805758468 no 2399 0.288866866880529 3482 1549512 SGTC_2725 haloperidol 53.21 µM -0.557388781428502 0.295736784709968 no 2400 0.288630914364593 3409 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2682 pyrogallin 40.03 µM -0.557698779126734 0.295634023977455 no 2401 0.288525045753958 3419 822798 An ATP competetive kinase inhibitor. SGTC_1272 0839-0021 27 µM -0.558655097605178 0.295317118675503 no 2402 0.288198564775749 3422 5027250 SGTC_263 alizarin 107.927 µM -0.559048875033207 0.295186673964576 no 2403 0.288064182366327 3442 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2140 5586273 200 µM -0.559470330825006 0.295047089775293 no 2404 0.287920387075184 3450 854421 SGTC_589 1227-0070 34.1 µM -0.562929294116725 0.293902647762412 no 2405 0.286741515807326 3481 2841384 SGTC_2232 chlorophetanol 41.5365 µM -0.563390121619368 0.293750332230967 no 2406 0.286584631156904 3489 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_296 1222-0039 74.9 µM -0.565392149181838 0.293089034252464 no 2407 0.285903531657424 3413 5984176 SGTC_1673 st016611 27.3 µM -0.566881769933886 0.292597439947603 no 2408 0.285397255283756 3492 5226799 SGTC_1285 0929-0069 65.5 µM -0.567282219770542 0.292465351636577 no 2409 0.285261227524826 3415 1206237 SGTC_1478 0453-0656 35.7 µM -0.568085371250334 0.292200515833023 no 2410 0.284988500239452 3491 5258496 SGTC_2058 5236698 133 µM -0.568252276083295 0.292145493676275 no 2411 0.28493183973784 3390 766665 SGTC_1174 0739-0097 51.1 µM -0.569370623753624 0.291776941556592 no 2412 0.28455232410874 3423 728447 SGTC_194 1486-1323 56.904 µM -0.569584682893099 0.291706422952826 no 2413 0.284479709843298 3441 5178754 SGTC_423 5-fluorouracil 457 µM -0.570935170693936 0.291261708056263 no 2414 0.28402179448328 3397 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1124 fisetin 1.16336 µM -0.571775447287148 0.290985165242358 no 2415 0.283737056580522 3418 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2883 9059145 45.46 µM -0.572474964938795 0.290755041118081 no 2416 0.283500120866427 3395 16476510 SGTC_199 4063-0024 41.6 µM -0.572939667024664 0.290602212607489 no 2417 0.283342772671683 3494 306215 SGTC_3123 9126162 49.47 µM -0.573183123056752 0.290522161213488 no 2418 0.283260355142776 3459 25239884 SGTC_2894 9048625 32.47 µM -0.575200317733258 0.289859279658675 no 2419 0.282577913963993 3544 4092861 SGTC_1148 3909-7663 27.7 µM -0.575662072037643 0.289707639854897 no 2420 0.28242180818128 3532 4084526 SGTC_3177 9107506 49.47 µM -0.576452396896064 0.289448184129283 no 2421 0.282154718481866 3466 8897194 SGTC_347 4534-1311 26.2 µM -0.578135826284061 0.288895895288724 no 2422 0.281586210452664 3471 2862016 SGTC_353 1988-1175 58.3 µM -0.578704143178443 0.288709557521735 no 2423 0.281394409947881 3360 2788357 SGTC_1795 st049545 62.3 µM -0.58024694967148 0.288203993074064 no 2424 0.280874048385932 3471 5291882 SGTC_2400 5203494 178.7 µM -0.580684571849801 0.28806066410923 no 2425 0.280726530837173 3477 6777674 SGTC_1629 st005085 44.9 µM -0.580965658073344 0.287968621171133 no 2426 0.280631799578652 3421 24207091 SGTC_2786 7743617 45.45 µM -0.581290672657886 0.287862211007451 no 2427 0.280522282933478 3382 583674 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.582050985537403 0.287613356220424 no 2428 0.280266169356469 3446 688761 SGTC_2179 6298986 200 µM -0.582101714608654 0.287596755922422 no 2429 0.280249085154555 3481 738374 SGTC_1045 1348-1485 165 µM -0.5825669890011 0.287444523258904 no 2430 0.280092416650336 3493 6810614 SGTC_3026 9090633 49.47 µM -0.582829059896977 0.287358793326246 no 2431 0.280004190091951 3439 25236842 SGTC_2485 5633444 17.78 µM -0.583283088016453 0.287210298031176 no 2432 0.279851372744346 3460 5724239 SGTC_2447 5741742 33.78 µM -0.583765777517182 0.287052468534424 no 2433 0.279688952891009 3486 1776504 SGTC_1159 4092-0538 61.2 µM -0.584290477703599 0.286880949017081 no 2434 0.279512448799352 3516 717301 SGTC_2147 5545932 89.7195 µM -0.584441051181792 0.286831736943585 no 2435 0.279461807320276 3472 797404 SGTC_2181 6316240 54.2555 µM -0.58549018512781 0.286488958598157 no 2436 0.279109082100738 3475 12779990 SGTC_2443 5493264 126.67 µM -0.586739009886757 0.286081189817487 no 2437 0.278689501996815 3509 5340055 SGTC_496 calpeptin 138 µM -0.586761124580834 0.286073971368517 no 2438 0.278682074670648 3465 73364 A calpain inhibitor. SGTC_587 k089-0003 57 µM -0.588892289724167 0.285378744913069 no 2439 0.277966765147223 3481 9659696 SGTC_1653 st012112 65 µM -0.589106796520167 0.285308813327039 no 2440 0.277894817217759 3527 720429 SGTC_1024 4507-0395 26 µM -0.591320130323213 0.284587719148083 no 2441 0.277152972064097 3562 4201836 SGTC_409 arachidonic acid 100 µM -0.592703492139036 0.284137468500072 no 2442 0.276689801980976 3502 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_856 0433-0016 11.3 µM -0.593275237737331 0.28395147875255 no 2443 0.276498483898011 3493 3911780 SGTC_1311 1190-0148 100 µM -0.593930689482568 0.283738330967107 no 2444 0.276279235812046 3539 1961333 SGTC_3139 9095020 49.47 µM -0.595556810377128 0.283209860247155 no 2445 0.275735668270784 3370 25236292 SGTC_3092 9117248 49.47 µM -0.595978096667072 0.283073024065098 no 2446 0.275594929615923 3527 17141857 SGTC_2091 4-phenylthiadiazole 200 µM -0.596189074869958 0.283004509071508 no 2447 0.275524461632609 3459 270010 SGTC_1234 0326-0494 15.5 µM -0.596821441491913 0.282799196246695 no 2448 0.275313300496867 3567 1547813 SGTC_400 oxethazaine 37.5 µM -0.596975508029494 0.2827491857323 no 2449 0.275261866357454 3479 4621 A local anesthetic. SGTC_1864 st057645 30.4 µM -0.598558079274854 0.282235723945383 no 2450 0.274733808950176 3558 688666 SGTC_191 3914-0123 66.505 µM -0.599473339044974 0.281938974861269 no 2451 0.274428641860605 3395 3144412 SGTC_2768 sulfasalazine 50.2 µM -0.601461552443552 0.281294866952201 no 2452 0.273766306172212 3576 5384001 An antioxidant and salicylic acid derivative. SGTC_621 3584-0052 32.1 µM -0.603622529766763 0.280595596548543 no 2453 0.2730473152371 3556 2273927 SGTC_3214 9129694 49.47 µM -0.604485863776429 0.280316465724954 no 2454 0.272760332415139 3510 17158655 SGTC_2029 5175081 200 µM -0.605049590377881 0.280134275762753 no 2455 0.272573023568402 3513 1380876 SGTC_2061 5245884 80.95 µM -0.605809639539675 0.279888727478247 no 2456 0.272320583956337 3500 573863 SGTC_2055 5235184 200 µM -0.606371845859137 0.279707163261074 no 2457 0.272133929820517 3532 2836034 SGTC_2990 9074105 71.4286 µM -0.60675959287713 0.27958197388993 no 2458 0.272005233749184 3505 6502001 SGTC_1016 4226-1401 38 µM -0.607585734697265 0.279315333578347 no 2459 0.271731132220368 3520 2901613 SGTC_2492 derrusnin 100 µM -0.608075415034184 0.279157345793318 no 2460 0.271568728512168 3487 1715307 Part of coumarin class of compounds. SGTC_2082 5219693 150 µM -0.608678170929133 0.27896293559551 no 2461 0.271368889402081 3530 2834649 SGTC_2698 st077697 67.5 µM -0.608742058636818 0.278942333400112 no 2462 0.271347712216726 3455 3154499 SGTC_3248 9135562 49.47 µM -0.610108040424066 0.278502015463657 no 2463 0.27089512038773 3563 17650701 SGTC_1111 tnp00062 510.699 nM -0.611911933390921 0.277921058208011 no 2464 0.270298012897615 3574 676306 SGTC_1066 ketoconazole 628 nM -0.613485832845502 0.277414655741902 no 2465 0.269777573739674 3574 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1782 st039423 80.636 µM -0.614051802483805 0.277232665231594 no 2466 0.269590548082441 3459 2068169 SGTC_2117 5521686 200 µM -0.615075384333117 0.276903675503884 no 2467 0.269252468740848 3522 803312 SGTC_2517 totarol 10 µM -0.616398486016678 0.276478700493434 no 2468 0.268815776167379 3502 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3140 9094243 49.47 µM -0.616996080868451 0.276286860298035 no 2469 0.268618655373679 3588 19291112 SGTC_2677 mitomycin C 100 µM -0.617246360339268 0.276206534866918 no 2470 0.268536120547359 3543 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1376 2910-0861 41.3 µM -0.617728222193517 0.276051916984723 no 2471 0.268377252550829 3547 1112859 SGTC_1335 1486-0900 202 µM -0.619516844190129 0.275478363121146 no 2472 0.267787964430146 3564 X1335 SGTC_2867 9039098 71.43 µM -0.620480634119128 0.275169549740277 no 2473 0.267470700003513 3531 6463460 SGTC_1527 coumarin 137 µM -0.621464443398351 0.27485449775083 no 2474 0.267147041146251 3577 323 A hepatotoxic, DNA x-linker. SGTC_2887 9044784 58.44 µM -0.622308918248586 0.274584207658469 no 2475 0.266869379053181 3562 6465546 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.622317524236366 0.274581453824945 no 2476 0.266866550167707 3545 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2897 9048598 12.99 µM -0.624078502554084 0.274018244453003 no 2477 0.266288015598336 3509 6467404 SGTC_3186 9110464 49.47 µM -0.62493107877664 0.273745772350631 no 2478 0.266008146791229 3575 17018021 SGTC_676 falcarinol 140 µM -0.627956971037532 0.272779820269976 no 2479 0.26501606409585 3625 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1237 0330-0133 46.1 µM -0.62872766649427 0.272534062525528 no 2480 0.264763681111035 3515 X1237 YHR072W ERG7 SGTC_1623 st003709 20.3 µM -0.628891286822504 0.272481901769813 no 2481 0.264710115383103 3563 16192618 SGTC_150 3970-0969 77.2 µM -0.629282386998148 0.27235724248207 no 2482 0.264582100047055 3568 6615640 SGTC_2086 5274770 176.623 µM -0.629773939924373 0.2722006050713 no 2483 0.264421249086844 3541 689278 SGTC_554 4483-2211 187 µM -0.630405636277836 0.2719993755589 no 2484 0.264214612070133 3514 747107 SGTC_2875 9039966 71.43 µM -0.631043885331444 0.27179613382246 no 2485 0.264005915126758 3558 6463691 SGTC_1134 3477-0009 42.5 µM -0.631512126310761 0.271647076921066 no 2486 0.263852861466974 3631 3973534 SGTC_2733 amorolfine 100 µM -0.632889732350414 0.271208774584023 no 2487 0.263402826659529 3570 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3325 9138760 55.175 µM -0.636028474103765 0.270211463819337 no 2488 0.262378931591406 3536 43844959 SGTC_2972 9093619 59.92 µM -0.6371232648252 0.269864034509776 no 2489 0.262022277806765 3549 25236256 SGTC_3080 9117754 49.47 µM -0.637474799209653 0.269752523336061 no 2490 0.261907809960587 3637 9550191 SGTC_1626 st003712 1.76 µM -0.637739874731288 0.269668453275417 no 2491 0.26182151211102 3555 24207035 SGTC_2854 9024559 71.43 µM -0.637903467567996 0.269616575518845 no 2492 0.261768260190936 3546 3163529 SGTC_231 b-estradiol 524 µM -0.637946289587375 0.269602996836214 no 2493 0.261754321899488 3519 450 A steroid. SGTC_284 0988-0104 32.6 µM -0.638769784807859 0.269341936626782 no 2494 0.261486353595739 3589 4666532 SGTC_410 α-linolenic acid 100 µM -0.639940076276152 0.268971155053747 no 2495 0.261105779007721 3614 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1696 st025591 34.7925 µM -0.640317609916286 0.268851596361517 no 2496 0.260983067188523 3593 2787147 SGTC_3073 9114972 49.47 µM -0.640656249303708 0.268744377549571 no 2497 0.260873022614979 3522 41905075 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.641339570896279 0.268528092092002 no 2498 0.260651042479805 3611 551469 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.642311019533419 0.268220759143852 no 2499 0.260335630395928 3606 279621 SGTC_487 nimodipine 119 µM -0.642498864170624 0.268161351985527 no 2500 0.260274663280065 3500 4497 L-type voltage-gated calcium channels inhibitor SGTC_93 0109-0045 59.227 µM -0.642637743604827 0.268117434667312 no 2501 0.260229593109071 3652 88733 SGTC_1934 st074720 32.6 µM -0.642664879969199 0.268108853860235 no 2502 0.260220787087124 3582 17250992 SGTC_2945 9067681 61.76 µM -0.645913611412279 0.267082570283246 no 2503 0.259167652025618 3661 16456930 SGTC_2420 aureobasidin a 50 nM -0.646718268642303 0.26682868358329 no 2504 0.258907148683836 3649 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2203 7227154 166.4 µM -0.648966794896613 0.266119872193392 no 2505 0.258179919514379 3601 896304 SGTC_120 rhodamine 6G 52.259 µM -0.649129848067206 0.266068509430888 no 2506 0.258127225284905 3613 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2362 9071156 126 µM -0.65168500901077 0.265264274204239 no 2507 0.257302197643461 3612 653133 SGTC_50 0929-0078 56.389 µM -0.652562873304514 0.264988252115115 no 2508 0.257019063539842 3507 1377751 SGTC_3122 9126309 49.47 µM -0.654465484547432 0.264390525736148 no 2509 0.256405978563933 3640 17591206 SGTC_413 propylparaben 100 µM -0.65570401083777 0.264001798115273 no 2510 0.256007293858226 3573 7175 A pharmaceutical preservative. SGTC_2174 5790901 200 µM -0.656695759062375 0.263690735135653 no 2511 0.255688280949502 3600 786020 SGTC_2765 myclobutanil 7.74 µM -0.657228210172632 0.263523808391618 no 2512 0.255517094550219 3618 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_15 0266-0086 27.098 µM -0.657486058744548 0.263442990641831 no 2513 0.255434216127605 3683 1712902 YIL048W NEO1 SGTC_693 4161-2696 114 µM -0.658253936320076 0.263202388927943 no 2514 0.255187485960253 3611 805759 SGTC_1446 4239-0190 62 µM -0.659695920238829 0.262750870677335 no 2515 0.254724492649915 3618 1340085 SGTC_2929 9013348 24.6 µM -0.662058858701687 0.262011837962483 no 2516 0.253966750535962 3611 2995952 SGTC_2947 9072639 7.68 µM -0.664764607145641 0.261166898622568 no 2517 0.253100531699701 3630 16488146 SGTC_3133 9127736 49.47 µM -0.66620122659763 0.260718847165469 no 2518 0.252641244513499 3633 27243420 SGTC_3290 9121031 71.43 µM -0.667984871591777 0.260163116655889 no 2519 0.252071624711534 3593 17014854 SGTC_2047 4141938 200 µM -0.668453416631664 0.260017233341684 no 2520 0.25192210394603 3598 3807862 SGTC_2070 5230947 200 µM -0.670110230167921 0.259501716532972 no 2521 0.251393761944466 3694 2835538 SGTC_1168 k815-0004 80.5 µM -0.672702931369392 0.258696059278468 no 2522 0.250568151157076 3620 642433 SGTC_1638 st008370 60.6 µM -0.673365190360969 0.258490476391952 no 2523 0.250357494258132 3634 24207134 SGTC_1164 k060-0068 93.7 µM -0.674490759476595 0.258141263893465 no 2524 0.249999679274407 3660 5963676 SGTC_1791 st048313 56.1 µM -0.674490759476595 0.258141263893465 no 2525 0.249999679274407 3581 1204976 SGTC_2963 9082507 9 µM -0.674490759476595 0.258141263893465 no 2526 0.249999679274407 3641 16459611 SGTC_3335 9143315 29.6265 µM -0.674819944310124 0.258039179179953 no 2527 0.249895083731544 3620 4899691 SGTC_1297 1068-0111 14.1 µM -0.675123223277852 0.257945146763645 no 2528 0.249798740107979 3605 767057 SGTC_2421 5690543 90.72 µM -0.675663886025096 0.257777557006489 no 2529 0.249627034929055 3644 3397993 SGTC_2565 isoliquiritigenin 100 µM -0.677911837489705 0.257081363764693 no 2530 0.248913796998581 3603 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_668 1682-0499 62.6 µM -0.679098655484291 0.256714199636886 no 2531 0.248537677164249 3667 682214 SGTC_1394 3474-0001 65.7 µM -0.681070341969014 0.256104825982965 no 2532 0.24791349112975 3594 5017666 YIL048W NEO1 SGTC_2427 5545055 42.75 µM -0.681140921414336 0.256083026542681 no 2533 0.247891162984862 3658 5372858 SGTC_1369 1866-0067 208 µM -0.68225256311456 0.255739808296386 no 2534 0.247539631448753 3660 3531355 SGTC_2168 5727979 200 µM -0.683712160715006 0.255289523976002 no 2535 0.247078471461524 3595 695210 SGTC_1851 st056236 18.9 µM -0.683748598949512 0.255278288124003 no 2536 0.247066964680999 3657 5393171 SGTC_1935 st074532 41.6 µM -0.686466311000784 0.254441001731275 no 2537 0.246209550718471 3714 2829742 SGTC_684 1140-0066 328 µM -0.687692855055758 0.254063593723572 no 2538 0.245823110168697 3669 6813534 SGTC_1854 st056233 32.9 µM -0.687747241640591 0.254046865755781 no 2539 0.245805982425545 3607 5393174 SGTC_462 ag-879 158 µM -0.688940049974178 0.25368013278071 no 2540 0.245430497359995 3659 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3354 9151612 71.43 µM -0.691176714053253 0.252993212981173 no 2541 0.244727247775373 3661 27261949 SGTC_2095 5432005 200 µM -0.692295588722019 0.252649954057815 no 2542 0.244375859894451 3670 783734 SGTC_782 0083-0095 30.5 µM -0.694308759438423 0.252032952855752 no 2543 0.243744299448159 3670 3591729 An indicator and reagent. SGTC_3288 9119690 36.221 µM -0.694690394744198 0.251916078091882 no 2544 0.243624674419657 3652 17595618 YKL019W RAM2 SGTC_209 4077-0173 175.592 µM -0.694727176594444 0.251904815262836 no 2545 0.24361314668499 3594 15993494 SGTC_477 mead ethanolamide 10 µM -0.695797528634095 0.251577183309279 no 2546 0.243277818585155 3546 16061185 SGTC_2815 7968870 71.43 µM -0.696169257053779 0.251463450904796 no 2547 0.243161419048424 3673 2977326 YHR190W ERG9 SGTC_2337 9009472 200 µM -0.696564937138833 0.251342420213832 no 2548 0.243037552605097 3685 5742383 SGTC_1163 k060-0048 49.9 µM -0.696863417571698 0.251251141349745 no 2549 0.242944136802691 3685 6809982 SGTC_1226 3909-7979 35.4 µM -0.697062004757655 0.251190420740061 no 2550 0.242881995480383 3686 6615510 SGTC_2874 9043904 71.43 µM -0.697632837032629 0.251015924588646 no 2551 0.242703420213686 3645 4463428 SGTC_1474 0330-0125 5.35 µM -0.69849706654838 0.250751862751601 no 2552 0.242433195877403 3678 X1474 SGTC_1950 st077106 7.18 µM -0.699535114707629 0.250434885879433 no 2553 0.242108838100843 3667 13831864 SGTC_1197 1601-0112 267 µM -0.700439034912269 0.250159039196203 no 2554 0.241826582912689 3676 7350313 SGTC_1412 3909-8563 178 µM -0.700980697170311 0.249993818961748 no 2555 0.241657530809643 3742 23767530 SGTC_2868 9035608 32.47 µM -0.702400428439908 0.249561041140334 no 2556 0.241214739095998 3671 6462614 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.702732870805325 0.249459760012493 no 2557 0.241111119338212 3612 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_44 0929-0055 61.211 µM -0.702886967471309 0.24941282068634 no 2558 0.241063096788716 3628 1379590 SGTC_1945 st075991 56.6 µM -0.704316046125509 0.248977733317848 no 2559 0.240617987830782 3604 1084980 SGTC_2394 5221648 200 µM -0.704370833291656 0.248961061240085 no 2560 0.240600932418346 3751 788586 SGTC_1514 1189-1591 158 µM -0.705739895823172 0.248544639924142 no 2561 0.240174952845095 3703 767698 YMR146C TIF34 SGTC_1334 1486-0610 236 µM -0.707025092694528 0.248154065580644 no 2562 0.239775442159971 3718 3742339 SGTC_76 0433-0009 400.328 µM -0.708880572706064 0.247590758833668 no 2563 0.239199295932006 3730 2841569 SGTC_2413 inermin 26.06 µM -0.709527033012527 0.247394659972937 no 2564 0.238998740988854 3752 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1268 0828-0275 2.46 µM -0.710121981644185 0.247214260170729 no 2565 0.238814248064502 3744 745337 SGTC_464 bw-b 70c 158 µM -0.710443056936746 0.247116933234826 no 2566 0.238714715339165 3713 5353454 SGTC_1242 0402-0103 60.1 µM -0.71173099004795 0.246726730632229 no 2567 0.238315686765246 3656 432868 SGTC_2611 pyromycin 23.93 µM -0.712532130100363 0.246484177319574 no 2568 0.238067661267857 3685 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2289 7946404 165.07 µM -0.712861632328758 0.246384454256517 no 2569 0.237965691522086 3737 1246120 YPR165W RHO1 SGTC_1600 coumarin 106 71.1 µM -0.71347100634819 0.246200085653069 no 2570 0.237777174068931 3770 100336 A hepatotoxic, DNA x-linker. SGTC_1386 3228-0095 33.8 µM -0.713525990146494 0.246183453719389 no 2571 0.237760168175119 3676 870181 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.714634680763925 0.245848216822118 no 2572 0.237417404555822 3718 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_275 trichlorophene 5.69 µM -0.714874558293536 0.245775716851713 no 2573 0.237343279553966 3747 62616 SGTC_2603 homopterocarpin 100 µM -0.715274829371151 0.245654765506417 no 2574 0.237219619343479 3736 101795 A weak amylase inhibitor. SGTC_481 bay k-8644 50 µM -0.715740472483558 0.245514100691837 no 2575 0.237075807565009 3675 2303 A calcium channel antagonist. SGTC_2914 7968218 45.32 µM -0.715856752086867 0.245478980867832 no 2576 0.237039902610161 3661 2977111 SGTC_698 k064-0052 127 µM -0.717397572425715 0.245013863251535 no 2577 0.236564408538187 3756 5088751 SGTC_779 1360-0071 233 µM -0.717469789578981 0.244992075156871 no 2578 0.236542135352466 3749 7566 SGTC_387 norethindrone acetate 66.7 µM -0.717941465463194 0.244849795011332 no 2579 0.236396689649404 3706 541197 SGTC_2640 pentamidine 10.38 µM -0.718322836938888 0.24473478754497 no 2580 0.236279126165937 3727 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_966 1300-0360 30.2 µM -0.718819047222586 0.244585192509854 no 2581 0.236126210103645 3704 70588 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.719111932038762 0.244496918155451 no 2582 0.236035978008093 3684 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3058 9093861 49.47 µM -0.719611737642849 0.244346318317917 no 2583 0.235882041540675 3713 17217477 SGTC_1087 pterostilbene 9.05 µM -0.720454618862809 0.244092457315097 no 2584 0.235622565697047 3722 5281727 Similar to reservatol, lowers cholesterol. SGTC_355 1311-2252 105 µM -0.720796416887699 0.243989554310422 no 2585 0.235517390143974 3708 5338538 SGTC_898 1000-0849 28.3 µM -0.724883041228847 0.242761034369589 no 2586 0.234261892802163 3671 6751807 SGTC_2342 7990637 118.86 µM -0.724921427042425 0.242749510730199 no 2587 0.23425011745885 3785 2033102 YER133W GLC7 SGTC_1652 st011932 78 µM -0.726100450822429 0.242395705347761 no 2588 0.233888596344291 3666 1551076 SGTC_3145 9085516 49.47 µM -0.726484664454624 0.242280469627766 no 2589 0.233770852699901 3747 25236195 SGTC_271 rotenone 740 µM -0.72654832556903 0.242261378861794 no 2590 0.233751346696494 3737 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2242 6630449 61.2675 µM -0.726587864339889 0.24224952234155 no 2591 0.233739232323484 3764 691249 YDR170C SEC7 SGTC_567 1080-0542 68.4 µM -0.726876801463803 0.242162888101871 no 2592 0.233650714792426 3647 5950415 SGTC_303 1348-1668 34.2 µM -0.727369595901422 0.242015168517926 no 2593 0.233499787303778 3733 5380509 SGTC_3000 9075062 71.4286 µM -0.727609259085886 0.241943344980732 no 2594 0.233426405531426 3700 17057871 SGTC_1804 st050076 49.1 µM -0.728519911035285 0.241670541430839 no 2595 0.23314769235781 3745 3895976 SGTC_2393 9031399 185.94 µM -0.730315116484651 0.241133242031965 no 2596 0.232598795143714 3748 1526623 YDL150W RPC53 SGTC_1172 0370-0043 85 µM -0.731103969687712 0.240897346265366 no 2597 0.232357824892808 3747 376585 SGTC_2652 actinonin 100 µM -0.731165705575616 0.240878890290124 no 2598 0.232338972349944 3710 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_691 1548-0686 185 µM -0.733072584835886 0.240309206744787 no 2599 0.231757080000089 3732 46495133 SGTC_2284 7945075 39.21 µM -0.734817320214682 0.239788607724257 no 2600 0.231225378634229 3814 1245402 SGTC_894 0960-0238 55.9 µM -0.735099208083572 0.239704555009255 no 2601 0.23113953829896 3704 6741907 YDL195W SEC31 SGTC_1921 5740136 50 µM -0.736386408766237 0.239320944709312 no 2602 0.230747786755522 3698 1774243 SGTC_2558 carylophyllene oxide 100 µM -0.736540820323142 0.239274949664845 no 2603 0.230700817482436 3811 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1937 st074714 47.2 µM -0.739336345612952 0.238443073717666 no 2604 0.229851392228095 3695 17250970 SGTC_294 k038-0071 157 µM -0.740547053577986 0.238083290391301 no 2605 0.22948406056933 3747 24152826 SGTC_2116 5511452 16.8835 µM -0.740969104728412 0.237957940384131 no 2606 0.229356086621098 3755 870744 SGTC_2534 helenine 20.12 µM -0.742226455103946 0.237584719439043 no 2607 0.228975071252136 3759 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1788 fluconazole 20 µM -0.744255911694955 0.236982991496191 no 2608 0.228360834152925 3770 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2803 7707263 71.43 µM -0.745853849790453 0.236509797565474 no 2609 0.227877853103063 3745 2199229 SGTC_815 1582-0027 36.9 µM -0.747210732397762 0.236108395445605 no 2610 0.227468183352323 3787 3128206 SGTC_2917 7979103 53.79 µM -0.750390940949504 0.235169077132645 no 2611 0.226509642683629 3791 2980565 SGTC_643 k048-0106 28.4 µM -0.750723417211347 0.235070994993407 no 2612 0.226409563481896 3777 6763920 SGTC_1981 st071826 47 µM -0.752082784520365 0.234670210086968 no 2613 0.226000638066976 3760 11838600 SGTC_2411 st077133 39.94 µM -0.752310234564232 0.234603187468331 no 2614 0.225932257252289 3870 1403142 YNL221C POP1 SGTC_3028 9087778 49.47 µM -0.753774471191989 0.234171974960601 no 2615 0.225492327813375 3732 17217395 SGTC_1378 2093-0007 380 nM -0.754874165034109 0.23384840778882 no 2616 0.22516224421482 3812 3618014 SGTC_451 chloral hydrate 100 µM -0.756427329001405 0.233391836711537 no 2617 0.224696513875092 3849 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1396 3511-0007 98.6 µM -0.75818158156714 0.232876748537133 no 2618 0.224171142943318 3747 X1396 SGTC_2770 toltrazuril 17.5 µM -0.758280382371771 0.23284775718712 no 2619 0.224141574428567 3726 68591 Kills coccidiodes. SGTC_3179 9107801 49.47 µM -0.758872956295684 0.232673918927056 no 2620 0.223964278932426 3775 4818259 SGTC_3005 9076496 71.4286 µM -0.759055281844189 0.232620446182029 no 2621 0.223909743969561 3787 21368410 SGTC_583 1488-1091 88.9 µM -0.759165312746434 0.232588179438712 no 2622 0.22387683653849 3863 4303273 SGTC_172 1112-0046 2.638 µM -0.759468655768574 0.232499236485108 no 2623 0.223786128627453 3735 2802135 YIL048W NEO1 SGTC_1031 k035-0009 16 µM -0.7607123364387 0.232134775721662 no 2624 0.223414452368864 3837 5180959 SGTC_2817 7995342 71.43 µM -0.761643941056598 0.231861977329263 no 2625 0.223136270844182 3762 18879975 SGTC_1198 1612-1005 86.7 µM -0.762055116338161 0.231741631187929 no 2626 0.223013554725332 3821 6998509 SGTC_1946 st076057 65.1 µM -0.763016421833371 0.231460404286487 no 2627 0.222726801127574 3660 953009 SGTC_3223 9129970 49.47 µM -0.763897896260975 0.231202699037707 no 2628 0.222464045605034 3829 17248386 SGTC_1523 st012844 44.7 µM -0.764060401459327 0.231155206982788 no 2629 0.222415624324986 3887 4274103 SGTC_1465 k213-0056 144 µM -0.764741458804632 0.230956227572552 no 2630 0.222212756719232 3676 24048857 YMR208W ERG12 SGTC_3235 9132602 49.47 µM -0.766990065164297 0.230299948655669 no 2631 0.221543711195939 3782 4912240 SGTC_2769 toremifene 3.73 µM -0.767105319550904 0.23026633859607 no 2632 0.22150944970096 3788 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2313 7726885 200 µM -0.767665976739442 0.230102880947814 no 2633 0.221342827206475 3794 726423 SGTC_1253 0550-0034 176 µM -0.77220574205081 0.228781721889157 no 2634 0.219996290598349 3799 5969915 SGTC_846 0335-0850 148 µM -0.772676433294313 0.228644985749596 no 2635 0.219856948619483 3805 6819598 SGTC_269 exalamide 29 µM -0.773018849408917 0.22854554246958 no 2636 0.219755612649366 3749 3316 A derivative of salicylamide. SGTC_1992 st073643 23.3 µM -0.77322976770437 0.228484300415391 no 2637 0.219693206008056 3764 3161292 SGTC_2207 7258803 200 µM -0.775769356670397 0.227747631773341 no 2638 0.218942590088287 3745 3666799 SGTC_337 1315-0038 354 µM -0.776062367466372 0.227662723072027 no 2639 0.218856081109675 3769 1626437 SGTC_2602 kawain 100 µM -0.777320480018873 0.227298349679901 no 2640 0.218484857516004 3746 5369129 SGTC_2226 7298446 200 µM -0.778082089593054 0.227077932791104 no 2641 0.218260310330035 3773 3283010 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.780114364925528 0.226490363617232 no 2642 0.21766178091418 3856 6708561 SGTC_2075 5212009 200 µM -0.780368782221306 0.226416867279965 no 2643 0.217586918734046 3683 780898 SGTC_1754 st042065 16.137 µM -0.781606878699331 0.226059396974484 no 2644 0.217222821547873 3716 1126236 YIL048W NEO1 SGTC_766 1391-0721 126 µM -0.783342287629344 0.225558877131945 no 2645 0.216713068422495 3792 1020919 YIL115C NUP159 SGTC_3355 9151058 44.0485 µM -0.784738072916155 0.225156765695097 no 2646 0.216303577637956 3812 17015728 SGTC_1824 st053723 68.6 µM -0.785407431827238 0.224964074416784 no 2647 0.216107362391755 3795 675225 SGTC_1633 st005664 67.9 µM -0.785513414246317 0.224933573367384 no 2648 0.216076304260472 3822 2063822 SGTC_3281 9140613 49.47 µM -0.787373060918363 0.224398760733829 no 2649 0.215531755920951 3803 16013766 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.788525354486654 0.224067737058163 no 2650 0.215194736987461 3815 442882 SGTC_1165 k072-0275 30.3 µM -0.788927137713824 0.223952380543762 no 2651 0.215077296745414 3804 6153523 YGL055W OLE1 SGTC_1572 epiandrosterone 68.9 µM -0.789171694209016 0.223882182128719 no 2652 0.215005831709504 3734 441302 A steroid. SGTC_3323 9138564 53.9225 µM -0.790453586249201 0.223514427648635 no 2653 0.214631458996649 3809 43912313 YNL103W MET4 SGTC_3102 9121669 49.47 µM -0.790482205076327 0.223506221284576 no 2654 0.214623105280296 3825 41905072 SGTC_1115 galangin 695.678 nM -0.791107573823498 0.223326941441429 no 2655 0.21444060993758 3846 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1177 0983-0204 23.6 µM -0.795083706046486 0.222188985459088 no 2656 0.213282406065625 3872 766818 SGTC_3234 9132280 49.47 µM -0.795150243310547 0.222169970905653 no 2657 0.213263055568361 3856 17612295 SGTC_3308 9128332 17.569 µM -0.795880729799765 0.221961278665041 no 2658 0.213050681381812 3827 17332805 YDL196W YDL196W SGTC_1371 2421-0008 32.7 µM -0.798200042071898 0.221299418145563 no 2659 0.212377206511595 3820 2827552 SGTC_3109 9122853 49.47 µM -0.798252213977808 0.22128454287777 no 2660 0.212362071311848 3888 1234709 SGTC_1385 3091-4834 14.1 µM -0.799227148394583 0.221006674529866 no 2661 0.212079356370052 3816 4072814 SGTC_1453 4237-0541 195 µM -0.799352936231492 0.220970837993795 no 2662 0.212042896003077 3764 739892 SGTC_2608 thymoquinone 42.66 µM -0.800555905489087 0.220628284106561 no 2663 0.211694393271516 3802 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_418 lividomycin a 100 µM -0.801255221403789 0.220429288928294 no 2664 0.211491954153169 3813 72394 An antibiotic. SGTC_1728 st035614 33.7865 µM -0.8013582628717 0.220399976464146 no 2665 0.211462135124746 3833 15945546 SGTC_2496 diffractaic acid 79.83 µM -0.801557736643796 0.220343238010726 no 2666 0.211404416681484 3837 94870 An apoptosis inducer which activates caspases. SGTC_450 aminopyrene 156 nM -0.803076338353983 0.219911560540005 no 2667 0.210965306492665 3755 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_34 0469-0683 81.75 µM -0.804550147205238 0.219493080327182 no 2668 0.21053966009286 3816 3690923 SGTC_736 0958-0254 92.6 µM -0.80535655302549 0.219264299434361 no 2669 0.210306977881191 3912 6812352 SGTC_2341 7987486 176.74 µM -0.805775985980021 0.219145358657618 no 2670 0.210186013437606 3859 1258686 SGTC_324 1315-0088 19.6 µM -0.805927923083075 0.219102282220107 no 2671 0.210142204869389 3801 6787421 SGTC_891 0929-0073 133 µM -0.807398633467519 0.218685565597143 no 2672 0.209718426997533 3906 5603632 SGTC_1989 st071868 50.2 µM -0.807828829308691 0.218563758576305 no 2673 0.209594563263267 3839 16414057 SGTC_1239 0337-0584 35.4 µM -0.808446011800686 0.218389075798075 no 2674 0.209416936738726 3908 914301 YML130C ERO1 SGTC_2353 9059630 146.67 µM -0.809711328073858 0.218031201558749 no 2675 0.209053052902699 3895 4779114 SGTC_1189 1431-2119 7.28 µM -0.810475655842406 0.217815187707211 no 2676 0.208833425510386 3865 3107275 SGTC_2821 7996764 71.43 µM -0.811860888804184 0.21742400876161 no 2677 0.208435729442764 3881 2987135 SGTC_1486 3970-0793 4.53 µM -0.811954162852544 0.217397683483287 no 2678 0.208408966813928 3891 2844330 SGTC_960 1222-0186 7.7 µM -0.812208100321162 0.217326022557507 no 2679 0.208336116150898 3916 3126296 SGTC_2903 5923464 63.88 µM -0.812976374838541 0.217109299261235 no 2680 0.208115801776707 3864 2876576 SGTC_3083 9117465 49.47 µM -0.813691201186604 0.21690776539847 no 2681 0.207910938015735 3807 16420915 SGTC_3260 9137109 49.47 µM -0.816225775189131 0.216194054859423 no 2682 0.207185508754772 3753 17478346 SGTC_3263 9137018 49.47 µM -0.818026093983145 0.215687930235248 no 2683 0.206671143790136 3873 43844957 SGTC_590 k048-0076 22.4 µM -0.820883445494926 0.214886053349404 no 2684 0.205856330719981 3852 6832814 SGTC_2824 7998404 51.95 µM -0.822717052389319 0.21437238993 no 2685 0.205334457918284 3833 837851 SGTC_455 paf C-16 10 µM -0.823405869722145 0.214179610519226 no 2686 0.205138613121446 3840 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2658 polymyxin b sulfate 77.05 µM -0.824374329607402 0.213908738182874 no 2687 0.204863448079931 3878 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2138 5575593 77.673 µM -0.825829573931493 0.213502090449292 no 2688 0.204450387646958 3843 762213 SGTC_2190 6049624 200 µM -0.826270487728658 0.213378972222042 no 2689 0.204325335412889 3762 2265554 SGTC_1733 st037357 54.9 µM -0.826369388116214 0.213351361531967 no 2690 0.204297291480231 3795 1272339 YGL099W LSG1 SGTC_1046 2001-0062 216 µM -0.827779404008012 0.21295794444468 no 2691 0.203897720402383 3776 739778 SGTC_2278 7948257 134.34 µM -0.829731085883304 0.212414092933557 no 2692 0.203345420848563 3875 1247028 SGTC_1452 4194-0072 190 µM -0.831554489418993 0.211906721202895 no 2693 0.202830229793939 3889 1343545 SGTC_190 3970-0790 3.722 µM -0.832913566186387 0.21152901242286 no 2694 0.202446739003766 3790 2832352 SGTC_1574 spiramycin 23.7 µM -0.834948151387967 0.210964306610468 no 2695 0.201873450939355 3854 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1860 st056228 74.6 µM -0.835073624323454 0.210929510143104 no 2696 0.20183812809311 3863 688679 SGTC_2601 securinine 100 µM -0.835733474683591 0.210746574185185 no 2697 0.201652429480294 3838 442872 A GABA receptor antagonist. SGTC_2952 9073731 13.78 µM -0.837207699493245 0.210338198625899 no 2698 0.201237915170953 3943 16457353 SGTC_1127 asiatic acid 681.4 nM -0.838180025371441 0.210069108739126 no 2699 0.20096480180596 3867 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1840 st055363 71 µM -0.838362048781827 0.210018756488218 no 2700 0.200913698580903 3921 676033 SGTC_1761 st044296 37 µM -0.839042582479377 0.209830566590738 no 2701 0.20072270725486 3890 1826700 SGTC_2718 lomofungin 53.02 µM -0.840094843120264 0.20953977721223 no 2702 0.200427605637831 3847 5351222 A RNA synthesis inhibitor. SGTC_1780 st038448 24.544 µM -0.840879658071685 0.209323050141055 no 2703 0.200207677684167 3953 728868 YDL195W SEC31 SGTC_497 capsazepine 133 µM -0.842122777643553 0.208980032115805 no 2704 0.199859616395457 3873 2733484 A calcium channel blocker. SGTC_701 4424-0219 185 µM -0.844127414805856 0.208427584036392 no 2705 0.199299104866493 3921 2911779 SGTC_1300 1094-0077 113 µM -0.844435879148523 0.208342652396947 no 2706 0.19921294004684 3846 5532636 SGTC_1641 st009299 47.1 µM -0.845069068601285 0.208168375904485 no 2707 0.199036138524307 3813 4046054 SGTC_599 1935-0052 86.5 µM -0.84663123894377 0.207738778596567 no 2708 0.198600348045311 3906 9557311 SGTC_270 tamoxifen 5.46 µM -0.846917289613688 0.207660171342889 no 2709 0.198520612370352 3926 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2700 st077718 96.8 µM -0.8470478190873 0.207624307441823 no 2710 0.198484234130283 3891 904970 SGTC_2839 9003951 25.97 µM -0.84742058258598 0.207521908171041 no 2711 0.19838036801296 3947 2990634 SGTC_611 3453-1652 23.7 µM -0.847670370854178 0.20745330727604 no 2712 0.198310785837814 3873 1560575 SGTC_3053 9095903 49.47 µM -0.848101636047235 0.207334897807741 no 2713 0.19819068528582 3975 17174018 SGTC_504 lovastatin 124 µM -0.848795864938123 0.207144372196128 no 2714 0.197997445749505 3925 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1414 3917-0015 5.4 µM -0.849099354951651 0.207061114312925 no 2715 0.197913004658016 3844 6618702 SGTC_2873 9040596 71.43 µM -0.849109200156453 0.207058413761866 no 2716 0.19791026575647 3877 6463863 SGTC_628 1636-0253 16 µM -0.849542791998155 0.206939499687552 no 2717 0.197789664732427 3913 4456143 SGTC_2028 5153890 36.43 µM -0.849780461590691 0.206874335125088 no 2718 0.197723577176449 3872 2830968 YPR165W RHO1 SGTC_2456 5770359 74.46 µM -0.850094903046272 0.206788139818708 no 2719 0.197636162574262 3929 3118787 SGTC_356 1634-0012 32.5 µM -0.850391355668991 0.206706895121123 no 2720 0.197553770257164 3873 735457 SGTC_1207 2099-0101 141 µM -0.850693371796437 0.20662414514924 no 2721 0.197469853046325 3936 5837381 SGTC_1877 wortmannin 25 µM -0.853398259832547 0.205883902840613 no 2722 0.196719243093751 3922 312145 A covalent inhibitor of PI 3-kinase. SGTC_340 k038-0059 454 µM -0.854985293189857 0.205450315301652 no 2723 0.196279644781914 3897 23733424 SGTC_1833 st055984 71 µM -0.855360937198484 0.20534776640467 no 2724 0.196175680973134 3933 676288 SGTC_952 1185-0122 232 µM -0.855548608766677 0.20529654441564 no 2725 0.196123753214819 3843 678600 SGTC_3258 9138477 49.47 µM -0.855786032491461 0.205231754237705 no 2726 0.196058071235699 3940 4970355 SGTC_118 0083-0097 135.343 µM -0.856035348078418 0.205163731986741 no 2727 0.195989113801215 3948 5207356 SGTC_495 decylubiquinone 155 µM -0.856519948492212 0.205031553914111 no 2728 0.195855121757761 3956 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_731 3966-0296 387 µM -0.858810541991935 0.204407464311835 no 2729 0.195222525240326 3920 660956 SGTC_983 1491-0821 12.2 µM -0.860986634944844 0.203815619935188 no 2730 0.194622702038272 3937 46495113 SGTC_1179 1021-1431 9.29 µM -0.862422512292662 0.203425656165335 no 2731 0.194227528347329 3957 2840958 SGTC_2291 7917025 104.35 µM -0.863076040497589 0.203248314748176 no 2732 0.194047830107765 3863 2964612 SGTC_2371 9071574 200 µM -0.864460320741503 0.202872981304805 no 2733 0.193667534328798 3921 45596039 SGTC_3175 9106517 49.47 µM -0.866018358640981 0.202451030874439 no 2734 0.193240047090603 3958 41468073 SGTC_1356 1502-0781 85.8 µM -0.866382466729707 0.202352498208752 no 2735 0.193140227879725 3879 567702 SGTC_2597 laccaic acid a 100 µM -0.866655024471119 0.202278759101691 no 2736 0.193065527544143 3946 5491415 A textile dye. SGTC_971 1315-0384 26.7 µM -0.868134772536948 0.201878701399343 no 2737 0.192660278575467 3959 6769120 SGTC_246 cycloheximide 667 µM -0.868820938055868 0.201693353796458 no 2738 0.192472539434874 3787 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2690 usnic acid 100 µM -0.869721195229785 0.201450330223218 no 2739 0.192226393193558 3921 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2309 7664088 163.95 µM -0.871625155680076 0.200936936258574 no 2740 0.191706451340514 3948 704922 SGTC_574 1315-0397 40 µM -0.872428606336817 0.200720525307612 no 2741 0.191487300164601 3925 6794277 SGTC_2097 5376186 200 µM -0.872769393837939 0.200628775823366 no 2742 0.191394392506398 3883 742755 SGTC_3336 9143619 71.43 µM -0.872797467151853 0.200621218828301 no 2743 0.191386740212561 3944 45595730 SGTC_310 1273-0058 1.06 µM -0.873906769744543 0.20032274486367 no 2744 0.191084513845862 3856 2734232 SGTC_1717 st033143 58.0435 µM -0.874039333841453 0.200287094423744 no 2745 0.191048416718139 3957 674616 SGTC_939 1165-0479 45.3 µM -0.874152041374191 0.200256787004802 no 2746 0.191017729810916 3895 1377347 SGTC_1702 st027038 51 µM -0.875179868470514 0.19998052816058 no 2747 0.190738022586864 3967 5521182 SGTC_787 4152-0075 138 µM -0.876239894326371 0.199695855109034 no 2748 0.190449816403971 3961 9566539 SGTC_1801 st050089 28.441 µM -0.876935857277445 0.199509084873019 no 2749 0.190260739328657 3976 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2245 6637752 200 µM -0.878633089058714 0.199054052867151 no 2750 0.189800124358888 4013 681890 SGTC_3243 9134147 49.47 µM -0.87999909605789 0.198688277598722 no 2751 0.18942989962216 3992 24282180 SGTC_3158 9100007 49.47 µM -0.880133650854148 0.198652269844096 no 2752 0.189393455704409 3963 19297233 SGTC_3030 9087619 49.47 µM -0.88072401214922 0.198494331768543 no 2753 0.189233608447673 3970 25236973 SGTC_917 harmaline 728.087 nM -0.881078865340175 0.198399435126287 no 2754 0.189137567758179 3936 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1416 3966-0321 25.3 µM -0.882754616569493 0.197951667231504 no 2755 0.188684432932045 3962 582530 YLR208W SEC13 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.883100586216209 0.197859298737921 no 2756 0.188590963735247 3926 15053 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.884040040566822 0.197608610479533 no 2757 0.18833729925801 4001 688798 SGTC_98 0074-0023 107.663 µM -0.884145525759093 0.197580474326645 no 2758 0.188308830080034 3954 3563821 SGTC_1250 0485-0349 40.2 µM -0.886416451415857 0.196975335874833 no 2759 0.187696578662197 3965 6842794 YDL195W SEC31 SGTC_932 2857-0803 154 µM -0.887135667941396 0.196783918864343 no 2760 0.187502931445551 4041 674898 SGTC_1678 st019265 80.2 µM -0.887150053781272 0.196780091271906 no 2761 0.18749905935475 3970 5367020 SGTC_3163 9099914 49.47 µM -0.888699725049468 0.196368039464469 no 2762 0.187082239450846 3946 16268368 SGTC_1998 st075797 76.8 µM -0.88958023796851 0.196134147544662 no 2763 0.186845660707136 3889 24208315 SGTC_2321 7390090 138.78 µM -0.890105396373476 0.195994729425473 no 2764 0.186704647819821 3983 649046 SGTC_1887 st057648 70.8 µM -0.890674228811355 0.19584378464844 no 2765 0.18655198215085 3977 688672 SGTC_297 0986-0032 24 µM -0.891414655893803 0.195647411407658 no 2766 0.186353379019 3916 2847425 SGTC_3048 9093155 49.47 µM -0.893470839507345 0.19510270551035 no 2767 0.185802540701867 3882 25236002 SGTC_812 4251-0442 148 µM -0.893640141523406 0.195057896636181 no 2768 0.185757230828832 3957 5723007 SGTC_1630 st005209 31.3 µM -0.894224536817952 0.194903273809382 no 2769 0.185600883253083 3889 3367314 SGTC_1341 1486-1360 280 µM -0.895288965701161 0.194621832392394 no 2770 0.185316318648243 3942 3976547 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.896129886010069 0.194399662939315 no 2771 0.185091698516707 3961 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2624 nerol 100 µM -0.896509567456903 0.194299402479172 no 2772 0.184990336387447 3872 637566 A natural product oil. SGTC_1203 3992-3522 103 µM -0.896894071154539 0.194197900728269 no 2773 0.18488772203659 4102 5322312 SGTC_2099 5377090 177.372 µM -0.897374471244409 0.194071129522369 no 2774 0.184759565072844 3998 2243829 SGTC_110 0850-0284 111.64 µM -0.897664653780032 0.193994578634209 no 2775 0.184682179455437 3768 3906265 SGTC_2627 acetyl isogambogic acid 100 µM -0.89909585126713 0.193617294331568 no 2776 0.184300803866355 3996 6857789 A caspase activator and apoptosis inducer. SGTC_808 0711-0032 135 µM -0.899315866152212 0.193559334941089 no 2777 0.184242219312147 3898 4252555 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.899481628968492 0.19351567437797 no 2778 0.184198088405762 4032 1273210 SGTC_2247 cerulenin 830 nM -0.899899684337076 0.193405588713268 no 2779 0.184086819069944 3987 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2621 lithochol-11-enic acid 100 µM -0.900899582842555 0.193142442510266 no 2780 0.183820856525598 3892 6708711 SGTC_1805 st050013 60.3 µM -0.901002833514967 0.193115282185725 no 2781 0.183793406566683 3909 4037144 SGTC_964 1287-0107 19.4 µM -0.90118647529203 0.193066980560161 no 2782 0.183744590344732 4001 51516812 YPR165W RHO1 SGTC_666 0272-0154 136 µM -0.902152439846314 0.19281303315924 no 2783 0.183487947683428 3983 6870312 SGTC_1117 retinoic acid 1.10837 µM -0.902312623389323 0.192770941415675 no 2784 0.183445410865818 4001 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1771 st048882 4.1505 µM -0.904575226349439 0.19217699266609 no 2785 0.182845232344391 3999 4580403 SGTC_1216 1165-0504 9.65 µM -0.907014659191329 0.191537880588595 no 2786 0.182199522637579 4011 6304004 SGTC_2432 5630864 12.22 µM -0.909494503500422 0.190889517381608 no 2787 0.181544578930688 4033 5714970 SGTC_1025 k007-0731 70 µM -0.911917076761554 0.190257429720584 no 2788 0.180906185668256 3952 6256118 SGTC_825 1988-2224 89.6 µM -0.913449394229296 0.189858288521963 no 2789 0.180503118725388 3961 1180859 SGTC_1113 artemisinin 1.17947 µM -0.91408262479846 0.189693493779408 no 2790 0.180336715833383 4018 2240 An anti-malaria and mitochondrial poison. SGTC_1529 apigenin 74 µM -0.917379077626427 0.188837032152302 no 2791 0.179472016230694 4002 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1367 1812-0510 76.9 µM -0.918689498120412 0.188497230686224 no 2792 0.179129002207199 4029 1142582 YDR527W RBA50 SGTC_1075 aripiprazole 15.2 µM -0.919849107555378 0.188196850297638 no 2793 0.178825808479679 4020 60795 An atypical antipschotic. YIL048W NEO1 SGTC_447 ml7 120 µM -0.920147378414567 0.188119635243801 no 2794 0.178747874264178 4010 4216 Selective myosin light chain kinase inhibitor. SGTC_2244 6635614 200 µM -0.921119558433504 0.187868097289203 no 2795 0.178494004991209 3917 836499 SGTC_3079 9117512 49.47 µM -0.923832318041501 0.187167307805902 no 2796 0.177786812994726 4027 7185044 SGTC_1384 3089-0840 101 µM -0.92513001222916 0.186832645777523 no 2797 0.177449141669764 3993 1069836 SGTC_1671 st016596 74.5 µM -0.925855257542377 0.186645773868112 no 2798 0.177260603002784 4051 2829167 SGTC_985 1493-0307 8.71 µM -0.927954626249257 0.186105488114395 no 2799 0.176715553283786 4021 3278274 SGTC_1746 st038117 42 µM -0.930009152746339 0.185577682406564 no 2800 0.176183172787366 4079 2898218 SGTC_1044 1222-0021 1.78 µM -0.93030221774318 0.185502470088046 no 2801 0.176107314945758 3977 4306703 SGTC_443 clozapine 122 µM -0.932417390746935 0.18496019242818 no 2802 0.175560430359453 3898 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.932484888532832 0.184942903911263 no 2803 0.175542996335462 4022 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1878 temozolomide 1 mM -0.933234205546301 0.184751045369852 no 2804 0.175349528719434 3902 5394 DNA alkylating agent. SGTC_897 1000-0139 31.4 µM -0.933599532048136 0.184657550391258 no 2805 0.175255253401088 3951 6151020 SGTC_2449 5812982 45.77 µM -0.934003640286378 0.184554164600086 no 2806 0.175151007606178 3959 776185 SGTC_2436 5633522 8.09 µM -0.934130901447136 0.184521613956376 no 2807 0.17511818682155 3992 5724242 SGTC_1467 k284-1082 293 µM -0.934162550932124 0.184513519259287 no 2808 0.175110024992516 3971 3334705 SGTC_742 0kpi-0133 140 µM -0.934691557102505 0.184378252925325 no 2809 0.174973639606135 4071 2728852 SGTC_3113 9123498 49.47 µM -0.936797858422652 0.183840285920121 no 2810 0.174431273566051 4094 8897275 SGTC_3103 9120822 49.47 µM -0.93682600055672 0.183833104808111 no 2811 0.174424034291092 4043 17141819 SGTC_560 2332-1943 155 µM -0.941590558786492 0.182619837939537 no 2812 0.173201152642898 3983 21177716 SGTC_2549 cedrol 20.94 µM -0.943763630905103 0.182068142073647 no 2813 0.172645224770176 3963 6708665 A sedative which affects the nervous system. SGTC_580 1123-0028 41 µM -0.94444188038003 0.181896162833481 no 2814 0.17247194427594 4079 1677248 YPR107C YTH1 SGTC_304 1310-0298 97 µM -0.944644068584148 0.181844914970002 no 2815 0.172420310309592 3869 1550234 SGTC_2726 cimetidine 79.27 µM -0.945437388136908 0.181643922574566 no 2816 0.172217810978713 4008 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_929 2805-0021 398 µM -0.946471861006328 0.181382041414196 no 2817 0.171953983959725 4097 3098024 SGTC_2157 5649910 96.377 µM -0.947767047441868 0.181054492964566 no 2818 0.171624029792126 4017 2858091 SGTC_130 0136-0219 337.655 µM -0.951154249904425 0.180199633755749 no 2819 0.17076303945165 3877 234244 SGTC_2060 5238662 140 µM -0.951196887290065 0.180188889140396 no 2820 0.170752219135941 4013 790130 SGTC_1520 flindersine 88 µM -0.953517032042798 0.17960481937017 no 2821 0.170164085371394 4160 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_261 5-fluorouridine 15.376 µM -0.95376901569772 0.179541457085578 no 2822 0.170100288242859 4022 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_627 1391-0720 175 µM -0.954823646710021 0.179276418435123 no 2823 0.169833443513265 4011 997839 SGTC_2027 5150920 200 µM -0.955413765796728 0.17912822339326 no 2824 0.169684247651323 3976 786715 SGTC_1142 3253-1408 9.78 µM -0.955670160984425 0.179063859570951 no 2825 0.169619451176513 4020 256655 SGTC_3331 9141060 1.957 µM -0.957164881892112 0.178688924036025 no 2826 0.16924201971029 3995 4906567 YPR165W RHO1 SGTC_1777 st045864 34.765 µM -0.959651615410033 0.178066248403465 no 2827 0.168615291137705 4014 4691462 SGTC_2444 5485484 36.41 µM -0.960278647758444 0.177909456335651 no 2828 0.168457496713969 4118 6790631 SGTC_1692 fluoroquinolonic acid 71 µM -0.960650854866629 0.17781642558277 no 2829 0.168363874691474 4088 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_122 0236-0016 402.397 µM -0.962601289160417 0.177329429025732 no 2830 0.167873825172466 4039 6808838 SGTC_292 k038-0015 474 µM -0.965093589824636 0.176708362813153 no 2831 0.167248968668629 4047 46368540 SGTC_2389 9091542 195.52 µM -0.96550714103342 0.176605441548237 no 2832 0.167145430490279 4035 3626624 YOL127W RPL25 SGTC_2292 7671323 168.05 µM -0.966208216917417 0.176431050101353 no 2833 0.166970001022409 4117 937504 SGTC_792 4534-1957 155 µM -0.96640157670675 0.176382971351633 no 2834 0.166921637709102 3989 1717904 SGTC_1507 4075-3230 155 µM -0.968398648428742 0.175886886147751 no 2835 0.166422657110281 3922 659771 SGTC_741 4582-0002 126 µM -0.968624407071943 0.175830861922557 no 2836 0.166366310580508 4017 2912688 SGTC_3173 9105693 49.47 µM -0.970267065442295 0.175423560496187 no 2837 0.165956694591646 4075 17096658 SGTC_930 2810-3379 265 µM -0.971579385208581 0.175098597524674 no 2838 0.165629921123764 4094 1015764 SGTC_2428 5615643 7.78 µM -0.973683872929323 0.174578271857224 no 2839 0.165106763570729 4110 2253075 SGTC_521 r062-0005 13.8 µM -0.977721051136318 0.173582848419678 no 2840 0.164106153613477 3977 2832033 SGTC_2020 4017018 200 µM -0.980030681753627 0.173015003695154 no 2841 0.163535486893556 4148 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1170 0310-0127 64.8 µM -0.980602003774774 0.172874721506219 no 2842 0.163394522911549 4077 774975 SGTC_896 0964-0007 44.5 µM -0.980691232852228 0.17285281877893 no 2843 0.163372514283981 4007 6756758 SGTC_1310 1188-0297 994 nM -0.981818901763221 0.172576166532236 no 2844 0.16309453722695 3947 1588352 SGTC_215 1287-0124 461.5 µM -0.982796239542563 0.172336623707577 no 2845 0.162853866503345 4092 5560863 SGTC_2364 9055074 200 µM -0.983548713418633 0.172152339010991 no 2846 0.162668726245824 4106 6470630 SGTC_322 k048-0136 19.3 µM -0.990291048756649 0.170506721948897 no 2847 0.161015940250649 4153 6823282 SGTC_1509 1326-1131 80 µM -0.992205615393562 0.170041271681467 no 2848 0.160548616902239 4019 768313 SGTC_2154 5570129 200 µM -0.993503130618928 0.169726296193873 no 2849 0.160232412795603 4115 673366 SGTC_158 k038-0087 26.446 µM -0.99397933458981 0.169610790263663 no 2850 0.160116464203576 3999 X158 SGTC_1504 k297-0033 30 µM -0.99490449429693 0.169386531801416 no 2851 0.159891358410139 3978 4388117 SGTC_2328 6201408 200 µM -0.994920322583944 0.169382696685443 no 2852 0.159887508942846 4084 2890418 SGTC_2907 7721985 69.9 µM -0.995893685141055 0.169146962823904 no 2853 0.159650901940851 4121 3267881 SGTC_1997 st073024 93.8 µM -0.996021322246161 0.169116066655614 no 2854 0.159619892648488 4086 686268 SGTC_2671 danthron 100 µM -0.996964692944158 0.168887824286862 no 2855 0.159390824026085 4072 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_970 1315-0089 19.5 µM -0.997266181403362 0.168814922875401 no 2856 0.159317662212922 4025 6811083 YLR033W RSC58 SGTC_883 0850-0245 24.6 µM -0.997386074214248 0.168785937816445 no 2857 0.159288574092289 4151 6823229 YPR165W RHO1 SGTC_2519 cryptotanshinone 88.04 µM -0.999368837376295 0.168307052554932 no 2858 0.158808025005287 4072 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2274 7947094 46.08 µM -0.999787913063678 0.168205947625794 no 2859 0.158706578203127 4042 2971028 SGTC_2164 5685496 200 µM -1.0017567117501 0.167731484329876 no 2860 0.158230554481527 3996 759046 SGTC_2231 micatex 6.853 µM -1.00201098495222 0.167670269608867 no 2861 0.158169143717363 4111 20737 An antifungal of unknown mechanism. SGTC_73 0327-0325 16.231 µM -1.00437741823858 0.167101255423958 no 2862 0.157598365157504 3970 53298 SGTC_3120 9124077 49.47 µM -1.00450624973573 0.16707031337992 no 2863 0.157567330173182 4196 18774327 YGL155W CDC43 SGTC_2326 6164455 177.58 µM -1.00553596288315 0.166823135293311 no 2864 0.157319420787281 4061 2888790 SGTC_517 1365-0151 113 µM -1.00589214886356 0.166737689370035 no 2865 0.157233726677113 4152 768657 SGTC_131 0141-0277 33.849 µM -1.00675892125857 0.166529876195562 no 2866 0.157025319791838 4070 1547771 SGTC_2878 9043973 25.97 µM -1.00762042417963 0.16632349214835 no 2867 0.156818360028273 4149 6465167 SGTC_2678 equilin 100 µM -1.00781206783993 0.166277603925706 no 2868 0.156772345684811 4112 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_662 k832-1615 104 µM -1.00993400157023 0.165770062872743 no 2869 0.156263455544488 4118 5878478 SGTC_2892 9047358 58.44 µM -1.0129279830135 0.165055643892193 no 2870 0.155547280568995 4110 6466771 SGTC_773 4358-1457 44.6 µM -1.01640739418796 0.164227900642934 no 2871 0.154717712988008 4106 1186886 SGTC_921 1561-0023 372 µM -1.02014439884617 0.163341880107423 no 2872 0.153829991314134 4081 24050882 SGTC_1060 3448-7350 82 µM -1.02045224471903 0.163269030466751 no 2873 0.153757013434307 4073 570178 SGTC_733 4069-0007 56.1 µM -1.02219101121639 0.162857959563532 no 2874 0.153345252151981 4107 5717425 YNL287W SEC21 SGTC_2092 5303694 80.6725 µM -1.0227403230505 0.162728233887187 no 2875 0.153215320347585 4103 1963699 SGTC_1157 4092-0394 27.6 µM -1.02577967472497 0.162011674648686 no 2876 0.152497724359696 4212 3659885 SGTC_448 monastrol 171 µM -1.02607219652274 0.16194281813233 no 2877 0.152428777321986 4028 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2792 7535235 81.82 µM -1.02767686211606 0.161565436124297 no 2878 0.152050927627109 4130 1281891 SGTC_2950 9072895 21.46 µM -1.02848071235109 0.161376603965561 no 2879 0.151861879532987 4088 17332245 SGTC_3220 9131269 49.47 µM -1.03130946447136 0.160713247797806 no 2880 0.151197860716638 4135 17722206 SGTC_1557 sumaresinolic acid 42.3 µM -1.03137237496913 0.160698515249094 no 2881 0.151183115150062 4093 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_502 l-744,832 89.3 µM -1.03232836262394 0.160474748037451 no 2882 0.150959159312863 4143 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_838 0109-0203 71.4 µM -1.03379501266777 0.160131846439199 no 2883 0.150616001840468 4129 759422 SGTC_774 k060-0086 136 µM -1.03393209080923 0.160099822176359 no 2884 0.150583955734291 4130 5911235 SGTC_2150 5556613 200 µM -1.03423726563635 0.160028542122226 no 2885 0.15051262832167 4129 743190 SGTC_2308 7584454 197.62 µM -1.03447048692487 0.159974082335086 no 2886 0.150458133524341 4195 893577 SGTC_547 1120-0019 610 nM -1.03544883910613 0.159745758209789 no 2887 0.150229673687452 4083 3676939 SGTC_3088 9117578 49.47 µM -1.03725669786814 0.159324408272545 no 2888 0.149808120326979 4170 678341 SGTC_3152 9099253 49.47 µM -1.03765516474766 0.159231637260925 no 2889 0.149715312735192 4059 25236131 SGTC_957 1187-1561 14.1 µM -1.04076683136827 0.158508396526314 no 2890 0.148991888730357 4096 1538454 SGTC_882 0843-0131 351 µM -1.04280763110121 0.158035227770823 no 2891 0.14851869816214 4136 5425421 SGTC_1961 st076550 68.7 µM -1.04384880372652 0.157794184708503 no 2892 0.148277673932234 4165 1579337 SGTC_1863 st057641 20.1 µM -1.0443106909804 0.157687330024897 no 2893 0.148170834077322 4153 3921635 SGTC_724 3910-0327 137 µM -1.04566731657335 0.157373758214388 no 2894 0.147857328804643 4201 2885483 SGTC_95 0471-0001 561.058 µM -1.045930595061 0.157312951282529 no 2895 0.147796538756152 4135 4015405 SGTC_197 4544-0043 41.561 µM -1.04719737750883 0.157020590551427 no 2896 0.147504277287109 4123 896523 SGTC_3198 9112019 49.47 µM -1.04730288525622 0.15699625655113 no 2897 0.147479952899967 4181 45595555 SGTC_906 1165-0455 526 µM -1.04736843116106 0.156981140483411 no 2898 0.147464842908513 4118 3252859 SGTC_872 0588-0139 234 µM -1.04866264013045 0.156682868646834 no 2899 0.147166707389407 4099 2047100 SGTC_476 mead acid 10 µM -1.05214478276133 0.155882204569555 no 2900 0.146366564260873 4176 5312531 An omega 9 fatty acid. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.05239320054562 0.155825188055359 no 2901 0.146309593487157 4116 6312947 SGTC_3171 9103192 49.47 µM -1.05731348311843 0.154698724876538 no 2902 0.145184270880007 4208 13018434 SGTC_1244 0416-0015 52.5 µM -1.05740501248956 0.154677820994161 no 2903 0.145163392439035 4121 96201 SGTC_307 1501-1223 22.3 µM -1.05746677033784 0.1546637175184 no 2904 0.145149306216429 4189 2830329 SGTC_3274 9138298 49.47 µM -1.06066461819636 0.15393459469438 no 2905 0.144421172458639 4121 17015756 SGTC_3318 9139014 38.6185 µM -1.06140479018575 0.153766157046577 no 2906 0.144252990458833 4150 16643984 SGTC_3295 9122362 53.5725 µM -1.06405059825404 0.15316506013098 no 2907 0.143652889303037 4181 4730473 SGTC_2295 7971645 200 µM -1.06435145519257 0.153096807663482 no 2908 0.14358475816019 4216 2978226 YKL099C UTP11 SGTC_982 1491-0518 27.5 µM -1.06454374765962 0.153053194716026 no 2909 0.143541223622288 4086 3091256 SGTC_2959 9079155 11 µM -1.06513276831943 0.152919652973181 no 2910 0.143407926255893 4200 16189457 SGTC_3245 9134821 49.47 µM -1.07068827423356 0.151663919733889 no 2911 0.142154808439104 4180 17014901 SGTC_1991 st073000 8.92 µM -1.07157235139532 0.151464722149779 no 2912 0.141956078712473 4232 4301969 YIL048W NEO1 SGTC_2071 5230951 39.92 µM -1.07342595121745 0.151047639618927 no 2913 0.141540023010328 4204 1799272 SGTC_885 0865-0106 16.8 µM -1.07356855206293 0.1510155843821 no 2914 0.14150804934104 4097 2793380 SGTC_1004 4084-0029 199 µM -1.07520604375381 0.150647817184587 no 2915 0.141141245084695 4195 716894 YLR208W SEC13 SGTC_3304 9125678 46.087 µM -1.07539065793859 0.150606391797565 no 2916 0.141099931294177 4103 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1781 st038725 66.3 µM -1.07610631780522 0.150445877329966 no 2917 0.140939855234854 4151 4270275 YIL048W NEO1 SGTC_66 0109-0187 42.4 µM -1.07795002957291 0.150032878690578 no 2918 0.140528028493708 4061 759417 SGTC_1985 st071382 65.5 µM -1.07945137204939 0.149697131015586 no 2919 0.140193280211717 4149 6123237 SGTC_3156 9099931 49.47 µM -1.08234217190636 0.149052069531577 no 2920 0.139550256809135 4202 18111053 SGTC_2064 5220758 200 µM -1.08274908249558 0.148961419617319 no 2921 0.13945990577803 4236 788518 SGTC_1768 st044301 37.178 µM -1.08458894644546 0.148552001946651 no 2922 0.139051876418067 4175 3931349 SGTC_2801 7907800 81.82 µM -1.08527580078513 0.148399352009784 no 2923 0.13889976023539 4200 6620925 SGTC_1389 3405-0187 19 µM -1.0863411961028 0.1481627808789 no 2924 0.138664033642865 4134 799890 SGTC_1956 st077085 54 µM -1.0880853525482 0.147776035767172 no 2925 0.138278714688847 4229 24208685 SGTC_2303 7774051 200 µM -1.09275540685399 0.146743839732615 no 2926 0.137250602764853 4238 2953184 SGTC_1648 st011736 69.8 µM -1.09276900581378 0.146740841111218 no 2927 0.13724761659927 4180 2855514 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.09551174122759 0.146136897957665 no 2928 0.136646252256935 4194 1377 SGTC_249 wiskostatin 11.211 µM -1.09930784318115 0.145303764505397 no 2929 0.13581690622161 4158 2775510 A n-wasp and actin depolymerizer. SGTC_3285 9112818 20.8695 µM -1.09953036724971 0.145255026320889 no 2930 0.135768397890831 4167 17017947 YPR165W RHO1 SGTC_2784 7567673 72.73 µM -1.09968536370228 0.145221084826804 no 2931 0.135734617010623 4162 3471247 SGTC_1013 4112-3890 241 µM -1.09980651180204 0.145194559242039 no 2932 0.135708217257327 4131 705171 SGTC_700 3453-2283 142 µM -1.10102318586315 0.144928347154401 no 2933 0.13544328310971 4245 565664 SGTC_1181 1222-0449 220 µM -1.10462550354345 0.14414207658639 no 2934 0.134660947721759 4265 658318 SGTC_2468 5987765 72.9 µM -1.10513977374159 0.144030062927369 no 2935 0.13454951428295 4235 26772094 SGTC_1498 4478-3555 97.6 µM -1.10831420122593 0.143339937725828 no 2936 0.133863072221959 4181 3437919 SGTC_3012 9080433 71.4286 µM -1.1083556435071 0.143330942903844 no 2937 0.133854126638336 4213 17688859 SGTC_887 0885-0007 9.62 µM -1.10966977739516 0.14304591495033 no 2938 0.133570675438219 4270 5719458 SGTC_1387 3342-1166 1.8 µM -1.11001048566788 0.142972079876635 no 2939 0.133497254033169 4169 3418228 SGTC_689 0833-0039 98 µM -1.11093503375382 0.14277185034057 no 2940 0.133298157128873 4158 5374726 SGTC_1681 tripelennamine 100 µM -1.11094873199731 0.142768885135434 no 2941 0.133295208815863 4148 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_248 streptozotocin 5.23457 mM -1.11403734186824 0.142101368636082 no 2942 0.132631583589937 4238 5300 DNA alkylating agent. SGTC_1199 1638-0010 4.46 µM -1.11415386350879 0.142076227165833 no 2943 0.132606592134785 4184 3111136 SGTC_323 4013-0906 34.3 µM -1.11457505099493 0.141985374115385 no 2944 0.132516283284394 4227 2910086 SGTC_1977 st070720 65.3 µM -1.1156215732628 0.141759802337615 no 2945 0.132292076857723 4237 682188 SGTC_2228 7354201 200 µM -1.1173750846603 0.141382387484417 no 2946 0.131916991804625 4276 753451 SGTC_1005 4092-0690 4.4 µM -1.11924803477013 0.140980018212214 no 2947 0.131517169105475 4229 1529343 SGTC_3056 9094900 49.47 µM -1.11974126580382 0.140874185824105 no 2948 0.131412017304908 4195 25236784 SGTC_2664 lyso-paf C-16 73.48 µM -1.12088692870361 0.140628569423877 no 2949 0.131167997755468 4188 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_715 0868-0130 184 µM -1.12190071199063 0.140411468961262 no 2950 0.130952328961832 4273 2876258 SGTC_2372 9071633 200 µM -1.12207527709179 0.140374109035189 no 2951 0.130915217321284 4250 21321366 SGTC_1826 st055655 41.6 µM -1.12443741707485 0.139869234191787 no 2952 0.130413753042238 4239 676168 SGTC_2352 9027995 87.8 µM -1.12848241588831 0.139007540891068 no 2953 0.129558119470099 4178 2997347 SGTC_2376 9072922 81.32 µM -1.12897422924789 0.138903018396914 no 2954 0.129454352579113 4232 17087968 SGTC_1698 5-fluorocytosine 1.055 µM -1.12901626774397 0.138894086660773 no 2955 0.129445485618281 4224 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1561 5-methoxyflavone 52.9 µM -1.13117797288555 0.138435325634738 no 2956 0.128990095535372 4163 94525 SGTC_358 0075-0058 9.45 µM -1.13176869683676 0.138310140973381 no 2957 0.128865845700277 4042 1069125 SGTC_853 0419-0306 21 µM -1.13206754352908 0.138246839573405 no 2958 0.128803019457826 4249 762713 SGTC_3114 9122766 49.47 µM -1.13295599642676 0.138058765048518 no 2959 0.128616366387586 4234 17176985 SGTC_824 1304-0008 100 µM -1.13411796471749 0.137813054136838 no 2960 0.128372534479119 4246 768245 SGTC_765 1319-0117 244 µM -1.13430948802901 0.137772583097114 no 2961 0.12833237531702 4200 3487746 YGL099W LSG1 SGTC_1562 morin hydrate 59.1 µM -1.14043135498013 0.136483234852947 no 2962 0.127053318052087 4274 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1814 st052110 31.539 µM -1.14219229602365 0.136113890155205 no 2963 0.126687048774743 4176 674163 SGTC_1273 0849-0096 14.1 µM -1.14376192000467 0.135785249993043 no 2964 0.126361193112116 4261 5286025 SGTC_2178 5812956 200 µM -1.14453934887851 0.135622677152397 no 2965 0.126200014475077 4198 5403383 SGTC_2030 5175110 200 µM -1.14704595198474 0.135099414580272 no 2966 0.125681314869371 4243 2831986 SGTC_459 nigericin 15.3 µM -1.14838883143433 0.134819653825354 no 2967 0.125404041111008 4313 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3309 9129340 25.759 µM -1.14881383074144 0.13473119699799 no 2968 0.125316377534064 4254 17158987 SGTC_1055 3448-0672 86 µM -1.14915622076912 0.134659962946987 no 2969 0.125245784696196 4233 748378 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.15271559081956 0.133920968976826 no 2970 0.124513570005239 4338 688801 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.15300673725578 0.133860644902429 no 2971 0.124453809595691 4250 5024745 SGTC_2495 cafestol 54.53 µM -1.15349434973025 0.133759655892281 no 2972 0.124353767701245 4257 16667697 An anti-infammatory. SGTC_463 ikarugamyin 104 µM -1.15375669138724 0.133705344206933 no 2973 0.124299967175708 4385 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_881 0833-0569 170 µM -1.15468507327565 0.133513266288891 no 2974 0.124109707144475 4252 5418700 SGTC_2007 4011539 71.82 µM -1.15541768924342 0.133361825462837 no 2975 0.123959710747485 4189 45595301 SGTC_1348 1493-0373 93.8 µM -1.15757276580084 0.132917029611792 no 2976 0.123519214267737 4265 3010129 SGTC_837 0091-0265 12.5 µM -1.15991977126308 0.132433783789266 no 2977 0.12304073608669 4218 759367 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.16050409320165 0.132313661023425 no 2978 0.122921814100073 4232 803109 SGTC_1499 4480-0877 67.3 µM -1.16118193616992 0.132174406663876 no 2979 0.122783959587548 4221 2861909 SGTC_2331 7980721 200 µM -1.16188972252171 0.132029108683907 no 2980 0.122640131173812 4203 2981221 SGTC_3054 9094397 49.47 µM -1.16611078040209 0.131164875947652 no 2981 0.121784829282616 4252 2598354 SGTC_1912 st060209 90.8 µM -1.16614691222325 0.131157495110661 no 2982 0.12177752612231 4250 688787 SGTC_1409 3909-8004 61.9 µM -1.16763305866106 0.13085416071553 no 2983 0.12147740469622 4298 2119279 SGTC_761 k216-0224 480 µM -1.16826684546527 0.130724947338721 no 2984 0.121349572229286 4301 1340404 SGTC_1350 1495-0454 146 µM -1.16966084569788 0.130441055764195 no 2985 0.121068740399823 4303 1069057 SGTC_552 k242-0005 476 µM -1.17100432508213 0.130167856664339 no 2986 0.12079851933097 4335 4088318 SGTC_2719 novobiocin 32.65 µM -1.17117395118342 0.130133391045285 no 2987 0.120764431747629 4293 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1903 st060211 78.3 µM -1.17217798727682 0.129929514468305 no 2988 0.120562802128996 4289 688960 SGTC_107 0358-0022 2.6945 µM -1.17425798743805 0.129507859650398 no 2989 0.120145852858072 4289 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2458 5808907 16.39 µM -1.1748709639679 0.12938377894055 no 2990 0.120023171885516 4406 2731747 SGTC_343 4130-2827 29.8 µM -1.17568410636965 0.129219307163444 no 2991 0.11986056605003 4257 1118244 SGTC_3006 9075424 71.4286 µM -1.17589289222396 0.129177100093757 no 2992 0.119818839764607 4213 7465181 SGTC_2783 7738165 71.43 µM -1.17792371053546 0.128767058914945 no 2993 0.119413510774757 4267 17201110 SGTC_1038 k292-0204 154 µM -1.18108119809186 0.128131327659025 no 2994 0.118785234170148 4220 4454212 SGTC_2721 ifenprodil 61.44 µM -1.18111236069735 0.128125064236235 no 2995 0.118779045096021 4280 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2758 dehydroepiandrosterone 69.35 µM -1.18285794643639 0.127774555664587 no 2996 0.118432725335732 4285 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3036 9090181 49.47 µM -1.18743483353591 0.126858696333984 no 2997 0.117528073452307 4320 25236586 SGTC_3097 9117246 49.47 µM -1.19622620650777 0.125112339516661 no 2998 0.115804148356988 4295 16423892 SGTC_714 4296-0578 26.1 µM -1.1968500623765 0.124989055173717 no 2999 0.115682500666727 4335 1589775 SGTC_3228 9131799 49.47 µM -1.20128201162158 0.124115670663292 no 3000 0.114820912905562 4310 17015818 SGTC_2349 9023730 187.07 µM -1.20237511528479 0.123900915612604 no 3001 0.114609113025378 4315 4126287 SGTC_180 1486-1293 102.781 µM -1.20292832741265 0.123792328757246 no 3002 0.114502028614121 4207 4140536 SGTC_2124 5246320 200 µM -1.20318098327393 0.123742758545824 no 3003 0.11445314610984 4304 579342 SGTC_626 0214-0009 33 µM -1.2045140756677 0.123481440508594 no 3004 0.114195472503224 4343 3437874 SGTC_555 4296-0685 37 µM -1.20478010954341 0.12342933779733 no 3005 0.114144100270236 4262 2908540 YHR072W ERG7 SGTC_2683 piperine 63.03 µM -1.20554173448613 0.123280258782755 no 3006 0.11399711839417 4276 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_927 2425-1185 123 µM -1.20698349143893 0.122998397602161 no 3007 0.113719250856913 4225 730375 SGTC_1057 3448-5381 134 µM -1.20813363275427 0.122773870998584 no 3008 0.113497932377313 4279 5497911 SGTC_3284 9108171 64.8615 µM -1.20863498738621 0.122676088299855 no 3009 0.11340155429151 4279 8687505 SGTC_1621 st003705 32.4 µM -1.20943711268317 0.122519757838182 no 3010 0.11324747887189 4299 24207032 SGTC_2540 epiandrosterone 100 µM -1.2110201388416 0.122211643734748 no 3011 0.112943843229946 4324 441302 A steroid. SGTC_1853 st056710 91.2 µM -1.21207020769629 0.122007562723966 no 3012 0.112742753414404 4356 269167 SGTC_2041 5107442 45.335 µM -1.21527798094068 0.121385614366201 no 3013 0.1121300435325 4332 793005 SGTC_719 2810-4230 27.3 µM -1.21684309719455 0.121082967799261 no 3014 0.111831959545562 4304 721079 SGTC_2706 st078239 82.5 µM -1.21787511195452 0.120883697721727 no 3015 0.111635717633837 4277 15434492 SGTC_772 k072-0172 35.3 µM -1.21811412073809 0.120837580830584 no 3016 0.111590304274157 4351 5861980 SGTC_2300 7976697 71.57 µM -1.21848476753064 0.120766088797079 no 3017 0.111519904907324 4197 2236109 SGTC_1359 1582-0056 520 nM -1.22094242895888 0.120292797092079 no 3018 0.11105390916543 4372 3661189 SGTC_1883 5-benzylidenerhodanine 20 µM -1.22096917342429 0.120287653891825 no 3019 0.111048845844977 4282 1273210 SGTC_2513 baicalein 25.65 µM -1.22154752695811 0.120176469223571 no 3020 0.11093939113824 4295 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1596 piperlongumine 63 µM -1.22260955260536 0.119972490387892 no 3021 0.110738601684996 4339 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1395 3486-0190 4.35 µM -1.22297250962385 0.119902834733865 no 3022 0.110670039788378 4290 6748079 SGTC_2997 9067075 71.4286 µM -1.22319872313206 0.119859436167195 no 3023 0.110627323874752 4293 27209819 SGTC_2969 9091408 28.7 µM -1.22696030300044 0.119139408038825 no 3024 0.109918755768932 4267 4286311 SGTC_200 k038-0079 37.545 µM -1.22721771359025 0.11909024729229 no 3025 0.109870386716975 4283 3436683 SGTC_680 0417-1641 114 µM -1.23099500376343 0.118370500075756 no 3026 0.109162366466209 4313 2835990 SGTC_1204 4049-0315 18.3 µM -1.23142203466804 0.118289324964347 no 3027 0.109082529977769 4358 588402 SGTC_1318 1280-3875 124 µM -1.23301832044179 0.117986232554506 no 3028 0.108784464538561 4309 373245 SGTC_1154 4088-0362 150 µM -1.23561788045738 0.11749382148623 no 3029 0.108300317571015 4318 6618304 SGTC_848 0368-0089 85.6 µM -1.23584719685054 0.117450454103635 no 3030 0.108257683799664 4307 762535 SGTC_1534 6-azauridine 81.6 µM -1.23654340089262 0.117318860274309 no 3031 0.108128321777107 4337 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2586 curcumin 80 µM -1.24211261405948 0.116269946761469 no 3032 0.107097507566578 4222 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2622 2-methoxyxanthone 59.94 µM -1.24536610306174 0.115660268079559 no 3033 0.106498603666911 4301 71034 A hepatoprotective. SGTC_2121 5257820 149.641 µM -1.2457009513965 0.115597649219114 no 3034 0.106437102122744 4367 791256 SGTC_1413 3910-0535 34.4 µM -1.2480451986964 0.115159933906489 no 3035 0.106007252681956 4347 2876951 SGTC_793 0488-0545 106 µM -1.24927203841435 0.114931330022923 no 3036 0.105782795685572 4348 292548 SGTC_104 0074-0074 590.992 µM -1.25060991437155 0.114682404258123 no 3037 0.105538415826242 4147 3943124 SGTC_669 0108-0021 26.2 µM -1.25541692443558 0.11379117618035 no 3038 0.104663724317687 4345 17201 SGTC_1856 st057054 55.7 µM -1.25657550283176 0.113577113927647 no 3039 0.104453694971065 4337 1266018 SGTC_2383 9036125 200 µM -1.25773181161253 0.11336375743742 no 3040 0.104244381714482 4255 79580 SGTC_2951 9072950 58.06 µM -1.25883143662685 0.113161125294959 no 3041 0.104045611455968 4272 16488155 SGTC_2236 dapsone 200 µM -1.26342672834051 0.112317129939507 no 3042 0.103217931773381 4329 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_821 1114-0266 29.2 µM -1.26445507548659 0.112128875835824 no 3043 0.103033367776277 4352 3123235 SGTC_3041 9091929 49.47 µM -1.27043216993529 0.111039145253073 no 3044 0.101965365071768 4337 25236887 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.27157707244826 0.110831277697407 no 3045 0.101761713633256 4316 6857784 SGTC_3187 9109394 49.47 µM -1.27290862041677 0.110589873802493 no 3046 0.101525234963427 4348 17098090 SGTC_311 1315-0136 58 µM -1.27509109503414 0.110195016099574 no 3047 0.101138500456386 4356 6759207 SGTC_3321 9137793 26.8275 µM -1.27521910010213 0.110171888599127 no 3048 0.101115851334947 4314 4904192 SGTC_3044 9093193 49.47 µM -1.27739788015991 0.109778768240777 no 3049 0.100730906398119 4370 25236277 SGTC_417 st075190 100 µM -1.2785795103175 0.109565986637124 no 3050 0.100522584555395 4340 222757 SGTC_1027 k015-0025 8.67 µM -1.27890513646618 0.109507401716636 no 3051 0.100465231825394 4337 3598955 SGTC_3143 9086658 49.47 µM -1.27907281532252 0.10947724260699 no 3052 0.10043570776174 4369 25236626 SGTC_1686 st019653 115.5 µM -1.27980320538265 0.109345942532751 no 3053 0.100307178140896 4341 97252 SGTC_553 k007-0256 45.7 µM -1.28043597938179 0.109232282095407 no 3054 0.100195923490769 4402 6287000 SGTC_1427 4048-4900 550 nM -1.28524463428631 0.108371312419593 no 3055 0.0993534053948544 4346 24132586 SGTC_1202 1988-0068 29.6 µM -1.28587445057181 0.108258909113598 no 3056 0.0992434408520639 4332 2850480 SGTC_1710 st031758 61.5 µM -1.2878077948622 0.107914389363983 no 3057 0.0989064391076328 4391 5394341 SGTC_2194 5927483 104.545 µM -1.28999532262407 0.107525527337377 no 3058 0.0985261410551686 4394 760979 SGTC_794 k038-0031 316 µM -1.29136727141226 0.107282161109909 no 3059 0.0982881769377934 4343 6624242 SGTC_1091 telmisartan 47.6 µM -1.29360195771114 0.106886606907692 no 3060 0.0979014729520509 4394 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1364 1653-0028 37.6 µM -1.29401328961065 0.106813913260753 no 3061 0.0978304152097737 4349 5718652 SGTC_2009 4012297 12.05 µM -1.29840827393756 0.106039424834573 no 3062 0.097073538734999 4336 45595307 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.30081644413108 0.105616779447231 no 3063 0.0966606459438329 4359 5379071 SGTC_3085 9117376 49.47 µM -1.30252228495273 0.105318134118949 no 3064 0.096368952499571 4443 16480349 SGTC_1965 Pectolinarigenin 58.4 µM -1.30289115933277 0.105253634881587 no 3065 0.0963059612877739 4355 5320438 An anti-inflammatory. SGTC_2904 7225135 42.03 µM -1.30738981268809 0.104469325133582 no 3066 0.0955401777114268 4440 4446116 SGTC_382 3229-0966 23.2 µM -1.31259795201401 0.103566620517873 no 3067 0.0946592300411914 4417 5722370 SGTC_1357 1503-1303 39.5 µM -1.31818144147641 0.102605159753276 no 3068 0.0937214582749517 4357 292895 SGTC_1002 4049-0206 172 µM -1.31923043575713 0.102425252303596 no 3069 0.0935460430319022 4336 4662749 SGTC_33 0986-0033 35.816 µM -1.31944904594873 0.10238778852766 no 3070 0.0935095170810889 4339 2848082 SGTC_2062 5245942 200 µM -1.32008336382695 0.102279140290894 no 3071 0.0934035932484881 4422 1376160 SGTC_282 k297-0036 65.7 µM -1.32560462523254 0.101336978759022 no 3072 0.0924853466952617 4393 5061378 SGTC_620 0109-0052 432 µM -1.32984797291075 0.100617192216504 no 3073 0.0917841830817559 4432 493037 SGTC_2936 9038235 15.59 µM -1.33083536243131 0.100450240411082 no 3074 0.0916215947174546 4308 4749415 SGTC_908 3448-7491 47.7 µM -1.33229610149054 0.100203623600761 no 3075 0.0913814538550542 4402 1203031 SGTC_488 nitrendipine 139 µM -1.33306991639036 0.100073159528725 no 3076 0.091254430345685 4422 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1881 5652484 16 µM -1.33359917495346 0.0999839987520597 no 3077 0.0911676267487533 4373 2255129 SGTC_913 3487-1245 167 µM -1.33726964468053 0.0993672541491658 no 3078 0.0905673178830301 4344 4016153 SGTC_1067 clotrimazole 1.36 µM -1.34010192640337 0.0988932536946906 no 3079 0.090106104943785 4430 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_127 0180-0333 59.125 µM -1.34121066720139 0.0987081500993273 no 3080 0.0899260319861927 4305 771601 SGTC_419 nsc-638432 893 µM -1.34302284442392 0.0984061543654466 no 3081 0.0896322884178939 4371 368090 SGTC_3124 9127567 49.47 µM -1.3434068500843 0.0983422475520343 no 3082 0.0895701350067667 4363 17592030 SGTC_133 0724-0033 378.92 µM -1.34597917070364 0.0979149415733372 no 3083 0.0891546170715689 4231 280309 SGTC_3167 9103034 49.47 µM -1.34695557942007 0.0977531003666125 no 3084 0.0889972697551313 4484 5127859 SGTC_965 1291-5240 308 µM -1.34748344886134 0.0976656869277382 no 3085 0.0889122902382636 4397 2834598 SGTC_167 3672-0051 66.205 µM -1.34990705147939 0.097265081927459 no 3086 0.0885228997657194 4309 3237971 SGTC_2925 9010536 32.5 µM -1.35000787407755 0.0972484427990814 no 3087 0.088506728573357 4319 2994177 SGTC_486 niguldipine 82 µM -1.35051938479861 0.0971640584589153 no 3088 0.0884247199760901 4470 1236 A calcium channel blocker. SGTC_3350 9150499 3.57 µM -1.35096093214186 0.0970912592574513 no 3089 0.0883539738887296 4400 4910996 YPR165W RHO1 SGTC_3070 9117005 49.47 µM -1.35180283483773 0.0969525632492636 no 3090 0.0882191985225715 4505 8779016 SGTC_2781 5567276 71.43 µM -1.35209272594758 0.0969048399382584 no 3091 0.0881728270043907 4412 2853274 SGTC_616 4092-0450 108 µM -1.35222897853652 0.0968824153210058 no 3092 0.0881510380662333 4401 787165 SGTC_22 0964-0034 14.468 µM -1.35313378788357 0.0967335973484622 no 3093 0.0880064466005061 4412 138402 SGTC_52 0329-0193 875 nM -1.35912552338292 0.095752345191297 no 3094 0.0870534081187472 4451 3739292 SGTC_273 hydroxyurea 18.1 mM -1.36076466078633 0.0954851876060117 no 3095 0.0867940365546453 4470 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2256 7954252 200 µM -1.36378005629995 0.0949951519245629 no 3096 0.0863183994947831 4416 2972920 SGTC_2216 7189485 200 µM -1.36735829417387 0.0944160545860405 no 3097 0.0857565139983155 4416 731273 SGTC_2649 anisomycin 9.56 µM -1.36878564248472 0.094185782138514 no 3098 0.0855331450771982 4449 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_18 0111-0177 500 nM -1.37275438251212 0.0935476877731001 no 3099 0.084914358281474 4499 721752 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.37396937481095 0.0933529809434615 no 3100 0.0847255951203023 4443 5357218 A potent inhibitor of glutathione S-transferases. SGTC_276 colchicine 750 µM -1.37899921172614 0.0925501163715479 no 3101 0.0839474984702895 4459 2833 A microtubule depolymerizer. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.3832210163332 0.0918801827999516 no 3102 0.0832985537639603 4431 115019 SGTC_1884 5633444 25 µM -1.38340407157175 0.0918512162874131 no 3103 0.083270501407766 4374 5724239 SGTC_503 tyrphostin 8 294 µM -1.38494198603405 0.0916081250298235 no 3104 0.0830351036657764 4464 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1229 0139-0193 12.2 µM -1.38509221317615 0.0915844048801695 no 3105 0.0830121363141264 4482 3090752 SGTC_3093 9117344 49.47 µM -1.38818938109214 0.0910963905070671 no 3106 0.0825396924740462 4440 24824913 SGTC_1337 1486-1011 40.3 µM -1.3895215238295 0.0908870816956896 no 3107 0.0823371102584476 4403 X1337 SGTC_2134 5324836 1.464 µM -1.38998368361722 0.0908145496966475 no 3108 0.0822669160352199 4405 699272 SGTC_2375 9072683 200 µM -1.39834017736722 0.0895104698892206 no 3109 0.0810054691300497 4475 16798029 SGTC_2987 9018338 71.43 µM -1.39894901022551 0.0894160050817437 no 3110 0.080914137067037 4445 5055682 SGTC_740 k014-0057 261 µM -1.40419167009211 0.0886056352251271 no 3111 0.0801308908353481 4433 4012779 SGTC_1294 1000-1494 117 µM -1.40440090633313 0.0885734070018794 no 3112 0.0800997505792819 4431 712797 YDL207W GLE1 SGTC_644 1498-1197 63.3 µM -1.40845938898345 0.0879500135468276 no 3113 0.0794975420923246 4466 6741615 SGTC_1254 0550-0035 264 µM -1.41111226807269 0.0875442964618394 no 3114 0.0791057565934783 4443 15121435 SGTC_1451 4152-0210 104 µM -1.41241963176188 0.0873448697632883 no 3115 0.0789132196737108 4474 659563 SGTC_334 1502-1024 68.5 µM -1.41330513792089 0.0872099864487443 no 3116 0.0787830119756792 4453 3296216 SGTC_1597 7-benzyloxygramine 47.5 µM -1.41363589465574 0.0871596443730477 no 3117 0.0787344182128272 4346 260807 SGTC_1431 4049-0260 9.09 µM -1.41566116003883 0.0868518666193965 no 3118 0.0784373676307642 4466 3854841 SGTC_786 4544-0069 423 µM -1.41762251599365 0.0865545758116689 no 3119 0.0781505014303833 4427 748821 YLR208W SEC13 SGTC_1479 0549-0158 134 µM -1.42777093352853 0.0850284795789734 no 3120 0.0766789008164837 4507 5440202 SGTC_592 k241-0073 46.5 µM -1.42990489042511 0.0847101618313356 no 3121 0.0763721591217109 4484 4230158 SGTC_586 0957-0265 8.15 µM -1.43280845086354 0.0842784803429551 no 3122 0.0759562927959913 4349 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1500 4488-1866 171 µM -1.43723300714666 0.0836238453896227 no 3123 0.0753258985809055 4504 2900003 SGTC_2956 9076196 2.52 µM -1.4375234527999 0.0835810065248957 no 3124 0.0752846568816958 4445 16423868 SGTC_771 0250-0039 27.3 µM -1.43978772589864 0.0832476060199641 no 3125 0.0749637324110089 4403 3005115 SGTC_1173 0443-0020 122 µM -1.44480187813655 0.082512862664234 no 3126 0.0742567717011886 4454 5331295 SGTC_1968 st069590 43.6 µM -1.44528290149535 0.082442633866055 no 3127 0.0741892193037552 4430 6384066 SGTC_615 k087-0205 167 µM -1.44592229456524 0.0823493529708118 no 3128 0.0740994989683722 4487 9642773 SGTC_588 3970-1144 52.9 µM -1.44899422241942 0.0819022980947372 no 3129 0.0736695980320989 4354 1888707 SGTC_2104 5389443 200 µM -1.44907933797672 0.0818899373964296 no 3130 0.0736577137404004 4489 2244536 SGTC_3002 9075603 71.4286 µM -1.45021215529572 0.0817255606183857 no 3131 0.0734996832262673 4417 20105405 SGTC_581 0958-0271 211 µM -1.45368371202047 0.0812233715051986 no 3132 0.0730170079998457 4471 4591145 SGTC_2525 harmine 47.85 µM -1.45435141307199 0.081127050612039 no 3133 0.0729244515712774 4447 5280953 A monoamine oxidase inhibitor SGTC_2401 5128683 200 µM -1.45614254621332 0.0808690919628056 no 3134 0.0726766090700487 4469 708373 SGTC_1473 k844-0725 134 µM -1.45931920724678 0.0804131135908244 no 3135 0.0722386356516291 4506 54682906 SGTC_709 3807-1509 243 µM -1.46223731226681 0.0799959626604009 no 3136 0.071838095095206 4542 1886677 YPL242C IQG1 SGTC_2229 7354935 190 µM -1.46349946369573 0.0798160424600743 no 3137 0.0716653801345667 4438 318112 SGTC_1512 0259-0544 12.2 µM -1.46765058816506 0.0792264564079898 no 3138 0.0710995795196598 4435 18476 SGTC_325 2810-4341 181 µM -1.47094326995644 0.0787611450481811 no 3139 0.070653229740307 4474 774970 SGTC_1689 st020265 53.493 µM -1.47331519193763 0.0784272377703818 no 3140 0.0703330330794839 4473 5758320 YPR016C TIF6 SGTC_1642 st009582 77.7 µM -1.47433714673466 0.0782837033686172 no 3141 0.0701954191339163 4463 6739311 SGTC_2222 6885208 172.143 µM -1.4755943384239 0.0781074031295735 no 3142 0.0700264129563853 4489 609514 SGTC_2864 9034755 47.6 µM -1.47691043606568 0.0779231651696941 no 3143 0.0698498235497139 4424 4930451 SGTC_2798 7813637 45.45 µM -1.47815001559479 0.0777499405770251 no 3144 0.0696838146715096 4473 956368 SGTC_2481 5478948 45.16 µM -1.47913891011484 0.0776119576022238 no 3145 0.0695515963556818 4478 77792 SGTC_2227 7312221 64.1025 µM -1.48341299014771 0.0770177219425837 no 3146 0.0689823591000154 4591 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3311 9131146 2.8755 µM -1.48952332889118 0.0761742008180319 no 3147 0.0681748074262375 4429 4900406 YPR165W RHO1 SGTC_252 miconazole 1.30953 nM -1.49258814736633 0.0757537651145902 no 3148 0.0677725139108462 4409 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_12 0849-0099 9.267 µM -1.49714209391519 0.0751323165239999 no 3149 0.0671781444116145 4436 6071388 SGTC_2654 protoveratrine a 100 µM -1.50442876348115 0.0741460473205766 no 3150 0.0662355013881464 4504 5702278 A heart drug and vasodilator. SGTC_2848 9016370 25.97 µM -1.5047847709736 0.0740981154040069 no 3151 0.0661897101627141 4467 7894410 SGTC_2504 purpurogallin 52.29 µM -1.5049399242719 0.0740772333774673 no 3152 0.0661697613470796 4432 5281571 An antioxidant. SGTC_1604 st002052 72.4 µM -1.51462196457722 0.0727830047715375 no 3153 0.0649340832714744 4549 6254834 YHR062C RPP1 SGTC_374 0880-0231 82.3 µM -1.51465749539397 0.0727782873473361 no 3154 0.064929581841545 4368 6833587 SGTC_1647 st011722 22.4 µM -1.5275436323792 0.0710827861350019 no 3155 0.0633129430484012 4491 2854783 SGTC_2580 diallyl disulphide 81.36 µM -1.53358535424914 0.0702983629669781 no 3156 0.0625658468153711 4497 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2275 7947463 200 µM -1.53632216800065 0.0699452285874021 no 3157 0.0622296926016973 4464 1225414 SGTC_1336 1486-0901 104 µM -1.53726780455807 0.0698235297735679 no 3158 0.0621138710789704 4518 5006114 SGTC_2051 5263410 176 µM -1.54056920796862 0.0693999326266649 no 3159 0.0617108334471914 4484 227584 SGTC_2813 7971799 71.43 µM -1.54117190594198 0.0693228156296332 no 3160 0.0616374765413862 4503 2234054 SGTC_639 0833-0042 114 µM -1.54589996943707 0.0687201340785572 no 3161 0.0610643639754188 4536 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3154 9100113 49.47 µM -1.54624072348299 0.0686768550794032 no 3162 0.0610232208990481 4505 25237525 SGTC_802 4112-3352 742 µM -1.55772521136723 0.067230474590039 no 3163 0.0596492007095723 4554 704594 SGTC_1683 st010134 710 nM -1.56903274240384 0.0658295020739309 no 3164 0.058320154944411 4497 3818134 SGTC_1927 st060202 13.8 µM -1.57008286285355 0.0657005518554046 no 3165 0.0581979174489227 4460 688887 SGTC_3206 9114350 49.47 µM -1.58166506571482 0.0642912667754897 no 3166 0.0568630258807216 4401 17087243 SGTC_1425 4048-4433 7.33 µM -1.58319596770145 0.0641067627692503 no 3167 0.0566884026268901 4610 23734946 SGTC_1448 4255-0083 152 µM -1.58467370056342 0.0639290573916472 no 3168 0.0565202451055814 4574 5399660 SGTC_1298 1079-1278 263 µM -1.58904009573402 0.0634062125740451 no 3169 0.0560256703522876 4519 2840950 SGTC_1954 st077032 68.9 µM -1.60355161763745 0.0616924492295719 no 3170 0.0544064613374755 4489 698907 SGTC_2343 7990716 14.84 µM -1.60407839706816 0.0616309253244226 no 3171 0.0543483865209464 4551 6456862 SGTC_53 0973-0023 39.979 µM -1.60804785718538 0.0611688615086054 no 3172 0.0539123489143079 4462 674768 SGTC_1489 4065-0444 182 µM -1.61102397797905 0.0608242062656877 no 3173 0.0535872481744086 4552 2877968 SGTC_2380 9035439 200 µM -1.61166897010051 0.0607497123379456 no 3174 0.0535169967301598 4598 6462575 SGTC_1785 bathophenanthroline 24 µM -1.61533345394614 0.0603278330319562 no 3175 0.0531192513491589 4484 72812 An iron chelator. SGTC_1760 st045453 10.4495 µM -1.61974605770016 0.059822872171308 no 3176 0.0526434190107316 4558 3323419 YIL048W NEO1 SGTC_2702 st077768 96.8 µM -1.62648643978584 0.0590579285176841 no 3177 0.0519231078588436 4513 6484119 SGTC_2830 7992007 71.43 µM -1.62707205862073 0.0589918325038309 no 3178 0.0518608972681868 4460 1952075 SGTC_2571 chrysanthemic acid 100 µM -1.63001165371389 0.058660930761478 no 3179 0.0515495169975416 4551 2743 An insecticide. SGTC_299 1273-0059 1.44 µM -1.63093497212477 0.0585572967117962 no 3180 0.0514520207332304 4334 2848077 SGTC_855 0428-0020 25 µM -1.63170490980589 0.0584709882051995 no 3181 0.0513708326311041 4583 6812414 SGTC_64 000l-0018 272.079 µM -1.63696631794001 0.0578838656175198 no 3182 0.0508187537586973 4483 6811119 SGTC_2397 5161689 200 µM -1.63945044321085 0.0576082764772132 no 3183 0.0505597417507131 4565 2259942 SGTC_1762 st045503 25.4615 µM -1.63974470432172 0.0575756995900151 no 3184 0.0505291298490573 4593 4645554 SGTC_538 2922-0838 53.3 µM -1.63987750414509 0.0575610024105056 no 3185 0.0505153195565751 4582 777039 SGTC_406 estrone 100 µM -1.6413952612671 0.057393239187312 no 3186 0.0503576964620554 4563 5870 A steroid. SGTC_1464 k208-0027 110 µM -1.64169455487215 0.057360202629222 no 3187 0.0503266603423254 4550 X1464 SGTC_2233 sulbentine 40.3845 µM -1.6439972830596 0.057106523591539 no 3188 0.0500883817958058 4583 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2054 5233173 129 µM -1.64690063471578 0.0567879368055423 no 3189 0.0497892357144487 4556 6889 SGTC_1847 st056231 15 µM -1.65897234283015 0.055478286467454 no 3190 0.0485606827699233 4541 5393180 SGTC_2429 5902844 64.44 µM -1.65910399616515 0.055464136074487 no 3191 0.0485474190847585 4559 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3098 9119039 49.47 µM -1.66129579868508 0.0552289746410926 no 3192 0.048327026700749 4554 17161528 SGTC_648 0375-0473 33.3 µM -1.66169405269321 0.0551863301041492 no 3193 0.0482870671065926 4570 1713139 SGTC_1345 1488-0192 31.4 µM -1.66527109934126 0.0548044694531632 no 3194 0.0479293408495181 4613 658348 SGTC_1276 0871-0068 94.2 µM -1.6693608238414 0.0543704412617524 no 3195 0.0475229463600663 4589 3414906 SGTC_169 k015-0017 16.025 µM -1.67108633187069 0.0541881367264874 no 3196 0.0473523133543743 4540 1840002 SGTC_1627 st003713 25.6 µM -1.67137587315802 0.0541575933646177 no 3197 0.0473237291955571 4576 16195070 YER133W GLC7 SGTC_208 k072-0098 12.366 µM -1.67269027040349 0.0540191104551569 no 3198 0.0471941428045734 4579 5948901 SGTC_36 0335-0881 14.2 µM -1.67670160328796 0.0535982149893803 no 3199 0.0468004234759836 4482 23828853 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.68004865653953 0.0532490119964174 no 3200 0.0464739246385953 4587 75037 A free radical scavenger. SGTC_354 2783-3500 4.88 µM -1.68012808962637 0.053240746586106 no 3201 0.0464661983548554 4559 6740761 SGTC_2214 7179297 48.276 µM -1.68130343438589 0.0531185649004019 no 3202 0.0463519955758584 4643 769744 SGTC_1040 k898-0338 155 µM -1.68149183908147 0.0530990001863926 no 3203 0.0463337101425572 4563 20969351 SGTC_13 0199-0087 65 µM -1.68917301676917 0.0523062091021482 no 3204 0.045593139184362 4678 4589825 SGTC_1839 st053978 48 µM -1.69116605138781 0.0521020469955715 no 3205 0.0454025464373007 4605 3788398 SGTC_984 1492-0255 2.91 µM -1.6914581832798 0.0520721749076692 no 3206 0.0453746639577218 4545 1585198 SGTC_2553 4-methylesculetin 85.09 µM -1.69301753781184 0.0519129524278503 no 3207 0.0452260645093084 4574 5319502 SGTC_1818 st052136 56.3 µM -1.69375263895922 0.0518380270592501 no 3208 0.0451561486097201 4235 674169 SGTC_827 3253-0474 693 µM -1.6944419292391 0.0517678490740894 no 3209 0.0450906688431122 4595 5402065 SGTC_1546 5-methoxyflavanone 78.7 µM -1.69680078110569 0.0515282610139474 no 3210 0.044867165517441 4607 147795 SGTC_2197 6588183 93.1375 µM -1.69780228635896 0.0514268053717881 no 3211 0.0447725421273837 4611 884136 SGTC_2838 9002687 71.43 µM -1.70124113637357 0.0510796478891655 no 3212 0.0444488581148459 4566 6457060 SGTC_2750 bromebric acid 70.15 µM -1.70366977979911 0.0508355980206934 no 3213 0.0442213984877538 4573 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1939 st074455 53.6 µM -1.71605296784745 0.0496056361750816 no 3214 0.0430761741470496 4540 1644229 SGTC_1651 st011928 86.1 µM -1.72438803695946 0.0487912099880958 no 3215 0.0423189078761697 4600 720198 SGTC_1424 4048-1941 275 µM -1.72835549822683 0.0484073181538749 no 3216 0.0419622543785502 4662 X1424 SGTC_1739 st037196 92.5 µM -1.72944127190959 0.0483026807061225 no 3217 0.0418650743876746 4591 612214 SGTC_151 3013-0144 2.285 µM -1.73005470106743 0.048243643759654 no 3218 0.0418102512549452 4364 906558 YHR107C CDC12 SGTC_1603 st002045 67.8 µM -1.74545496125063 0.0467803355190542 no 3219 0.0404528528859974 4597 5887985 SGTC_51 1013-0126 23.419 µM -1.74650210236937 0.0466821449156489 no 3220 0.0403618710366139 4587 1627850 SGTC_2416 tofa 880 nM -1.74698622411392 0.0466368046692413 no 3221 0.0403198638667679 4562 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_192 3455-0609 60.9 µM -1.76077672841907 0.0453600340409249 no 3222 0.0391381000731352 4658 3769639 SGTC_809 3998-0021 90 µM -1.76732834212993 0.0447633936319093 no 3223 0.0385866279794829 4567 715485 SGTC_1955 wogonin 32.4 µM -1.77101655793628 0.0444303064001041 no 3224 0.0382789741582432 4590 5281703 A flavanone. SGTC_2604 4'-hydroxychalcone 11.32 µM -1.77214437528602 0.0443288515073634 no 3225 0.0381852971858411 4583 5282362 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.77781999735653 0.0438211210231685 no 3226 0.0377167115254377 4595 61125 An anti-inflammatory. SGTC_2659 sanguinarine 24.21 µM -1.77876063510303 0.0437374282894902 no 3227 0.0376395067416669 4589 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_656 4090-1979 187 µM -1.77923948315766 0.0436948726058227 no 3228 0.0376002538852843 4644 22330961 SGTC_3210 9128157 49.47 µM -1.78104669316269 0.0435345650234394 no 3229 0.0374524115274783 4561 17590849 SGTC_1725 st036284 20.55 µM -1.78279634517755 0.0433798156841098 no 3230 0.037309730467074 4604 707914 SGTC_2418 pentamidine 31.67 µM -1.78570280600755 0.0431237333779984 no 3231 0.0370736954027306 4564 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1483 3453-0561 55.9 µM -1.79228858338111 0.0425479913852154 no 3232 0.0365433755580416 4651 4546991 SGTC_1632 st005650 90 µM -1.79481837056818 0.0423284913845327 no 3233 0.0363413214581173 4629 2759605 SGTC_1993 st073995 70.8 µM -1.80133694882787 0.0417671185707208 no 3234 0.0358248937271416 4624 3098394 SGTC_3037 9091026 49.47 µM -1.80168848276117 0.0417370170244918 no 3235 0.035797215566135 4505 25236398 YIL048W NEO1 SGTC_2759 disulfiram 3.38 µM -1.81057676513744 0.0409817419239111 no 3236 0.0351031957686745 4532 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_545 4218-0007 221 µM -1.81132664168082 0.0409185320915768 no 3237 0.03504515201683 4631 2840508 SGTC_40 0327-0103 19.753 µM -1.81350110126373 0.040735686010157 no 3238 0.0348772844558173 4481 409036 SGTC_1323 1348-1351 11.2 µM -1.81557912287127 0.0405615693173121 no 3239 0.0347174792611719 4635 6989654 SGTC_479 n-linoleoylglycine 10 µM -1.8210232570678 0.0401082705565366 no 3240 0.0343016608223154 4660 6433346 An anti-infammatory. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.82137138362443 0.0400794248231305 no 3241 0.0342752110454859 4648 6708784 An antioxidant flavonoid SGTC_1658 st012944 20 µM -1.82176660937949 0.0400466968880745 no 3242 0.0342452031115629 4491 24207260 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.82195369171841 0.0400312125097107 no 3243 0.0342310062190843 4647 94937 An inhibitor of serotonin biosynthesis. SGTC_1363 1636-0063 10.4 µM -1.82277600007995 0.039963209601161 no 3244 0.0341686620482443 4651 6072185 SGTC_415 dibenzyl ketone 100 µM -1.83278895890037 0.0391426699648573 no 3245 0.0334169808735563 4623 7593 SGTC_1783 st039459 87.517 µM -1.84428300576343 0.0382177204152872 no 3246 0.0325709534233562 4672 729761 SGTC_1001 4048-4355 44.4 µM -1.84634679780703 0.0380535454635669 no 3247 0.0324209334084773 4629 21824233 SGTC_475 α-linolenic acid 10 µM -1.84907174322335 0.0378376574193885 no 3248 0.0322237269651548 4642 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_58 0957-0393 9 µM -1.85205682920294 0.0376023076315958 no 3249 0.0320088314126923 4178 6997992 SGTC_3004 9076122 71.4286 µM -1.85227319090948 0.0375852958251728 no 3250 0.0319933016953881 4628 44782551 SGTC_6 0844-0013 19.835 µM -1.85675659945685 0.0372341922478717 no 3251 0.0316728954735106 4725 1584900 SGTC_1834 st055981 52.8 µM -1.86049727443668 0.0369433082140008 no 3252 0.0314076018561992 4622 471719 YDL150W RPC53 SGTC_703 3875-0075 71.8 µM -1.88007244667092 0.0354512485889666 no 3253 0.0300491025228742 4682 2850814 SGTC_1608 st001473 40.5 µM -1.88354111355389 0.0351920847059131 no 3254 0.0298135367941338 4637 7292267 SGTC_2018 5133068 143 µM -1.89012287934623 0.0347045965389952 no 3255 0.0293707639186317 4620 785362 SGTC_1800 st050079 29.0735 µM -1.89767893011812 0.0341517983387981 no 3256 0.0288691948860068 4492 3645560 SGTC_2826 7992541 19.48 µM -1.90944350652462 0.033305532027748 no 3257 0.0281024514544694 4642 2985066 SGTC_823 0417-1665 178 µM -1.9159348666726 0.0328460284121872 no 3258 0.027686693381539 4681 3429856 SGTC_101 0490-5701 117.494 µM -1.91925574891146 0.0326129814670687 no 3259 0.0274759876388015 4553 4661669 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.92372185066591 0.0323017191873234 no 3260 0.0271947288177668 4637 6728940 SGTC_1430 4049-0248 69.1 µM -1.92742310880739 0.032045623714227 no 3261 0.0269634610044128 4667 22774488 SGTC_1304 1165-0502 251 µM -1.93401200132999 0.0315938779295648 no 3262 0.0265558261450045 4663 767425 SGTC_533 1222-0222 6.71 µM -1.93750846971936 0.0313562996414141 no 3263 0.0263416095288904 4689 3982874 SGTC_541 4513-1321 94 µM -1.94256377226842 0.0310154152340061 no 3264 0.0260344438368591 4650 747515 SGTC_155 k072-0202 43.6 µM -1.95156577217543 0.0304159944429202 no 3265 0.0254948901345347 4659 5857737 SGTC_327 1273-0057 3.96 µM -1.96394971018119 0.0296070926503791 no 3266 0.0247679621081883 4619 3108138 SGTC_422 cantharidin 155 µM -1.96520139437133 0.0295263371897408 no 3267 0.0246954663263443 4610 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2805 7950783 58.44 µM -1.96932439037 0.0292616240824693 no 3268 0.0244579260442156 4659 1178958 YDL195W SEC31 SGTC_1545 lovastatin 49.4 µM -1.99538399551087 0.0276337267107058 no 3269 0.0230005075615498 4709 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2818 7996756 12.99 µM -2.00044508710242 0.0273264878004097 no 3270 0.0227261119587037 4682 2241621 SGTC_2689 tacrolimus 100 µM -2.00236149154608 0.0272108965245302 no 3271 0.0226229334701341 4661 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1133 3473-0247 50 µM -2.02432403912647 0.0259150705494801 no 3272 0.0214684108884588 4655 711311 SGTC_2272 7805186 180 µM -2.03480127215831 0.0253153259501641 no 3273 0.0209354365136014 4692 2956062 YPR165W RHO1 SGTC_2688 kanamycin b 96.69 µM -2.03928526863825 0.0250622265887186 no 3274 0.0207107825088954 4624 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_219 mitoxanthrone 164.414 µM -2.04021037067772 0.0250102739868322 no 3275 0.0206646886356413 4677 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3019 9081971 49.47 µM -2.04146231682508 0.0249401100154115 no 3276 0.0206024478987104 4672 16451803 SGTC_1513 0337-0559 19 µM -2.04475679036425 0.0247562630211815 no 3277 0.0204394208325933 4668 775073 SGTC_1905 st060207 84.5 µM -2.05668268400281 0.0241002219034979 no 3278 0.0198583794426728 4691 1948547 SGTC_2709 st078560 56 µM -2.06291825660669 0.0237630593165306 no 3279 0.0195601976262767 4668 17250903 SGTC_1042 0350-0096 82 µM -2.06677816997429 0.0235563445049869 no 3280 0.0193775306963628 4686 3122515 SGTC_830 4076-0286 57.8 µM -2.07065968118536 0.0233500004278674 no 3281 0.0191953052980257 4727 6866659 SGTC_3130 9127414 49.47 µM -2.08100992335833 0.0228071971572466 no 3282 0.0187164988834044 4715 1494646 SGTC_523 1934-0222 13.7 µM -2.10490569413808 0.0215945142439887 no 3283 0.0176497589728745 4691 1361595 SGTC_2471 5466956 24.79 µM -2.10644560575683 0.0215182705228616 no 3284 0.0175828316606678 4724 724419 SGTC_1666 st014829 29 µM -2.12778731451932 0.0204848190331286 no 3285 0.0166773608053449 4736 3858230 SGTC_2971 9092186 9.93 µM -2.13142704504461 0.02031283477789 no 3286 0.0165269883917459 4659 25236400 SGTC_1077 5-fluorocytosine 377 nM -2.14668347107357 0.0196051973387255 no 3287 0.0159092447720397 4745 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2836 9010338 19.48 µM -2.1522405889277 0.0193526963939333 no 3288 0.0156892051793196 4659 2994051 SGTC_3268 9137683 49.47 µM -2.15732175392794 0.0191242451944789 no 3289 0.0154903015798584 4745 1953228 SGTC_1726 st035556 14.5795 µM -2.16925193058742 0.0185968557359218 no 3290 0.0150317812497282 4713 5919439 SGTC_3273 9137859 49.47 µM -2.17192659156005 0.0184803329731671 no 3291 0.0149306001867081 4747 2377234 SGTC_2089 5281248 129.67 µM -2.17763420856145 0.0182337558905752 no 3292 0.0147166403084086 4713 2737878 SGTC_3279 9140807 49.47 µM -2.18281226640668 0.0180124873619993 no 3293 0.0145248189893276 4751 45595718 SGTC_2005 4024620 188 µM -2.20799897134006 0.0169685821192923 no 3294 0.0136221724358416 4694 236743 SGTC_1616 st002734 56.1 µM -2.22714060160067 0.016210222698959 no 3295 0.0129689392060348 4718 4026101 SGTC_2498 4'-Methoxychalcone 54.63 µM -2.25096863039727 0.0153069252243562 no 3296 0.0121937621459629 4725 641818 YHR062C RPP1 SGTC_1715 st032160 10.2275 µM -2.25144513043752 0.0152893115978284 no 3297 0.0121786792240651 4659 5289825 SGTC_3346 9158254 43.5805 µM -2.25297283992577 0.0152329577712531 no 3298 0.0121304307581623 4717 17639500 SGTC_2777 climbazole 1.536 µM -2.25508225429088 0.0151554394575028 no 3299 0.0120640831462631 4529 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_999 SEC7.066 22.7 µM -2.25585711463931 0.0151270495572611 no 3300 0.012039790525357 4720 740511 YDR170C SEC7 SGTC_2367 9070478 135.38 µM -2.2653409861305 0.0147832582968208 no 3301 0.0117458813669942 4704 572802 SGTC_206 4546-0025 72.014 µM -2.27948983815799 0.0142828601516856 no 3302 0.0113189816775194 4734 6620745 YIL048W NEO1 SGTC_39 0986-0283 58.349 µM -2.28404208109405 0.0141249955386493 no 3303 0.0111845289733842 4738 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_379 3970-0972 5.9 µM -2.28850967643016 0.0139715305054293 no 3304 0.0110539286266184 4741 2898042 YBL034C STU1 SGTC_760 0568-0725 82.9 µM -2.29376071260871 0.0137929932622411 no 3305 0.0109021236251095 4733 3916171 SGTC_1078 idebenone 36.1 µM -2.30346790046131 0.0134681226219297 no 3306 0.0106262656015814 4760 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2822 7994718 71.43 µM -2.3158397595013 0.0130636650676808 no 3307 0.0102835097319845 4742 1018011 SGTC_109 0132-0036 33.701 µM -2.35132371778116 0.0119613498522494 no 3308 0.0093533756056641 4722 67274 A color developer. SGTC_2479 5617353 43.85 µM -2.36401956562971 0.0115870311493916 no 3309 0.00903892890926126 4733 2731746 SGTC_1502 4534-4282 27.7 µM -2.38239550215498 0.0110632734899991 no 3310 0.00860020648228952 4764 3278949 SGTC_2459 5811157 9.22 µM -2.38576441226253 0.0109695184452012 no 3311 0.00852183268749567 4733 2870684 YBR192W RIM2 SGTC_2812 7970281 58.44 µM -2.38734361565296 0.0109258085032997 no 3312 0.00848531058082115 4745 2233435 SGTC_142 0335-0849 62.6745 µM -2.40052812507014 0.0105667584330539 no 3313 0.00818571630453059 4708 3889043 YPR107C YTH1 SGTC_2085 5307070 144.047 µM -2.40781097876261 0.010372868242537 no 3314 0.0080242438660512 4720 2840351 SGTC_3029 9088683 49.47 µM -2.41163033571759 0.0102724314006799 no 3315 0.00794068721007401 4752 25236615 SGTC_1772 st048439 82.2 µM -2.41496287019631 0.010185490301813 no 3316 0.0078684068931536 4757 2927068 YDL195W SEC31 SGTC_1724 st037281 8.293 µM -2.49159486002705 0.00835587640695091 no 3317 0.00635855017038862 4727 574124 YDL195W SEC31 SGTC_573 3702-0553 84.7 µM -2.51533263689202 0.00785098231162358 no 3318 0.00594600620730947 4750 1222756 SGTC_384 k007-0144 5.16 µM -2.55517130065629 0.00706376973096069 no 3319 0.00530677754843779 4757 6824886 SGTC_3134 9127454 49.47 µM -2.57570258860588 0.00668594271202031 no 3320 0.00500183256456344 4764 24262820 SGTC_663 1486-0733 13.9 µM -2.59259006530333 0.00638867537482355 no 3321 0.00476281180317127 4769 722445 YPR165W RHO1 SGTC_3074 9116018 49.47 µM -2.59424838886466 0.00636012458174175 no 3322 0.00473989860812707 4762 17027303 SGTC_2106 5357045 167.29 µM -2.63182979374111 0.00574267501230153 no 3323 0.004246319871493 4781 668842 SGTC_426 0988-0037 14.6 µM -2.65007683999275 0.0054625363113585 no 3324 0.00402367329923355 4754 5383008 SGTC_2251 lansoprazole 556 µM -2.65076673235601 0.00545218716945057 no 3325 0.00401546431367534 4765 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2043 5101342 149 µM -2.66492232419212 0.00524365003459248 no 3326 0.0038503053649252 4778 678451 SGTC_2339 9000433 200 µM -2.67915448938399 0.0050411683855788 no 3327 0.00369041657720807 4751 2988954 SGTC_1741 st038134 10.228 µM -2.6962707132862 0.00480689789116258 no 3328 0.00350603267984264 4772 1272587 SGTC_193 1273-0060 1.558 µM -2.70483517427959 0.00469335973401712 no 3329 0.00341691443550801 4720 2847393 YHR072W ERG7 SGTC_1900 st060200 72.8 µM -2.75277793874935 0.00410086927243517 no 3330 0.00295459815242952 4776 688945 SGTC_2507 purpurin 79.67 µM -2.77365126170112 0.00386452289971852 no 3331 0.00277155321826188 4767 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1679 SEC14.276 6.7 µM -2.81782321609794 0.00340418271337046 no 3332 0.00241752115419924 4748 1005053 YMR079W SEC14 SGTC_65 0798-0905 34.986 µM -2.82041265813041 0.00337879265532977 no 3333 0.00239809640206332 4751 3602145 SGTC_1960 st011366 51.8 µM -2.90410600358723 0.00264451688051833 no 3334 0.00184151718834683 4798 3972846 SGTC_2146 5545642 200 µM -2.95978590512559 0.00223933402629291 no 3335 0.00153926450464075 4781 825326 SGTC_2966 9084041 48.03 µM -3.0307553588586 0.00180466324227126 no 3336 0.00121971405841551 4771 17741380 SGTC_137 0438-0332 85.389 µM -3.03555524457544 0.00177823874981635 no 3337 0.00120046617342872 4758 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1255 0566-0045 221 µM -3.07225102614008 0.00158756754280016 no 3338 0.00106225490255397 4788 2788469 SGTC_391 gliotoxin 8.33 µM -3.11207016864337 0.00140189779569456 no 3339 0.000928901677855684 4800 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1003 4049-0218 100 µM -3.15686258874244 0.00121688576724784 no 3340 0.000797382392751736 4789 295161 SGTC_2332 7982454 138.89 µM -3.15956775147159 0.00120646226805828 no 3341 0.000790016796375898 4769 2981748 SGTC_1953 st076800 12.1 µM -3.17084765550503 0.00116387367108899 no 3342 0.00075997416580123 4781 297591 SGTC_2975 9084847 53.72 µM -3.19089999443151 0.00109154746804397 no 3343 0.000709151818939554 4783 27211724 SGTC_532 1548-0774 215 µM -3.36367647412628 0.000619083781324548 yes 3344 0.000384558231439946 4799 5932993 SGTC_2486 5283202 22.39 µM -3.41096926578069 0.000527699930072308 yes 3345 0.000323661938298203 4795 1377751 SGTC_2512 diallyl trisulfide 49.23 µM -3.45220287710646 0.000458381463620052 yes 3346 0.000278014741881812 4805 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_138 0850-0259 40.9225 µM -3.73712732514198 0.000166391770583781 yes 3347 9.30673399242903e-05 4786 6813004 SGTC_1896 st058441 89 µM -3.93765429529431 7.8164515796945e-05 yes 3348 4.11410114226827e-05 4805 688759 SGTC_3072 9116419 49.47 µM -3.95621878894211 7.27547598464752e-05 yes 3349 3.80727138936137e-05 4804 17170162 SGTC_3211 9128781 49.47 µM -4.08952854934407 4.30865004759327e-05 yes 3350 2.16125432566045e-05 4783 17194361 SGTC_1767 st044992 70.3 µM -4.29927303060437 1.83089465817805e-05 yes 3351 8.56796320816084e-06 4809 9600693 SGTC_1745 st081495 74 µM -4.81990162110274 1.85053055011856e-06 yes 3352 7.18145155991646e-07 4797 13842402 YBL026W LSM2 SGTC_1893 st059353 36.1 µM -5.00209161441909 7.8406919056008e-07 yes 3353 2.83558134058732e-07 4810 3112488 SGTC_371 0195-0006 7.36 µM -5.33735805704657 1.49472534742264e-07 yes 3354 4.71553407956323e-08 4724 3928593 SGTC_365 0121-0052 13.6 µM -5.42630991867818 9.46856630839493e-08 yes 3355 2.87655153194727e-08 4806 3101739 SGTC_363 0455-0021 3.06 µM -11.554496476377 6.95249012581617e-29 yes 3356 3.50284442504795e-31 4810 4597466