SGTCid condition conc unit YOL092W|YOL092W.score YOL092W|YOL092W.strain.pval YOL092W|YOL092W.strain.significant YOL092W|YOL092W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1399 3562-5772 25 µM 5.7455342407544 5.71202226160618e-10 yes 1 4.58156057807569e-09 3 23847490 SGTC_762 1165-0429 115 µM 5.20489862432689 1.74459536843072e-08 yes 2 9.70512694625281e-08 5 5967793 SGTC_2054 5233173 129 µM 5.08786578866764 3.50628462317859e-08 yes 3 1.81057740072719e-07 23 6889 SGTC_1987 st072290 61.9 µM 4.89324876630689 1.08291258490299e-07 yes 4 4.95924526748653e-07 3 54697379 SGTC_2646 retinol 96.75 µM 4.45868694670207 1.15751834064885e-06 yes 5 4.12316280862428e-06 3 445354 A vitamin A analog and teratogen. SGTC_2052 5265182 7.135 µM 4.42697530799432 1.36498383335631e-06 yes 6 4.77818334508781e-06 17 1239884 SGTC_849 0386-0493 241 µM 4.32414956438345 2.3122669593279e-06 yes 7 7.65606959145533e-06 10 726119 SGTC_1131 3454-3128 32.3 µM 4.30677769909197 2.52476251357845e-06 yes 8 8.2824966821693e-06 29 710982 SGTC_180 1486-1293 102.781 µM 4.21205250967825 4.05442842699297e-06 yes 9 1.26530348006414e-05 37 4140536 SGTC_594 1487-1584 10.8 µM 3.93751793575619 1.51485880480002e-05 yes 10 4.11643899884209e-05 26 5013332 SGTC_2343 7990716 14.84 µM 3.86366210797742 2.12989873493147e-05 yes 11 5.58498528575723e-05 20 6456862 SGTC_2422 chlorphenesin carbamate 384.24 µM 3.8066226126973 2.76000548588591e-05 yes 12 7.04387321203265e-05 30 2724 A muscle relaxant with antifungal properties. SGTC_2419 paclitaxel 166.5 µM 3.79918033209791 2.85419319540173e-05 yes 13 7.25877164873432e-05 47 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_790 1575-0012 79.1 µM 3.7337855284798 3.82323106084061e-05 yes 14 9.43115663601853e-05 34 378741 YLR208W SEC13 SGTC_2571 chrysanthemic acid 100 µM 3.71928594782299 4.07669594150913e-05 yes 15 9.98933873001542e-05 29 2743 An insecticide. SGTC_1323 1348-1351 11.2 µM 3.66107253587973 5.26319438469306e-05 yes 16 0.000125580816452254 15 6989654 SGTC_2786 7743617 45.45 µM 3.62146927860312 6.24920090830735e-05 yes 17 0.000146467298061942 38 583674 SGTC_2105 5350118 200 µM 3.57782228948747 7.53652827474858e-05 yes 18 0.000173234438724384 36 2133313 SGTC_1767 st044992 70.3 µM 3.57173667377645 7.73469537676573e-05 yes 19 0.000177310938235948 31 9600693 SGTC_1673 st016611 27.3 µM 3.47775762319459 0.00011490406535212 yes 20 0.000252813451851145 65 5226799 SGTC_1735 st034310 56.75 µM 3.41717030445198 0.000147566187943442 yes 21 0.000316378417471162 45 871153 SGTC_3275 9138069 49.47 µM 3.36917943399219 0.000179409735587198 yes 22 0.000376961657840833 12 17617007 SGTC_1979 st071809 45.3 µM 3.31092805919037 0.000226684208095878 yes 23 0.000464935555244583 35 4976333 SGTC_182 3448-4371 550.524 µM 3.28089289582881 0.000255378380176199 yes 24 0.000517395152707881 48 3491403 SGTC_3150 9097574 49.47 µM 3.19493130507027 0.000357304398674758 yes 25 0.000699320635256072 25 17217476 SGTC_135 0933-0004 26.348 µM 3.19431218245712 0.00035815955265462 yes 26 0.000700822279854804 52 21230617 YGL099W LSG1 SGTC_2706 st078239 82.5 µM 3.18730251134075 0.000367975106242956 yes 27 0.000718032451153717 39 15434492 SGTC_3309 9129340 25.759 µM 3.18439956198638 0.000372112763775834 yes 28 0.00072527319385011 44 17158987 SGTC_3332 9141069 11.198 µM 3.18251024793048 0.000374828825613918 yes 29 0.000730021744134532 41 17332883 SGTC_2188 6126565 140.678 µM 3.17584395461415 0.000384560003585298 yes 30 0.000747006463331382 34 874518 SGTC_2971 9092186 9.93 µM 3.15848084903638 0.000411017859970128 yes 31 0.00079296864542726 61 25236400 SGTC_3065 9113888 49.47 µM 3.08224960204928 0.000548395474487652 yes 32 0.00102721246071862 52 16648368 SGTC_2675 theaflavin digallate 100 µM 3.05345110322861 0.000610537011986766 yes 33 0.00113112792890831 69 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1325 1431-0015 227 µM 3.02638782559237 0.000674800954253089 yes 34 0.001237473169349 53 1103340 SGTC_3076 9116187 49.47 µM 3.01350614252769 0.000707532161154527 yes 35 0.00129123906622299 46 27241210 SGTC_2790 5423970 71.43 µM 2.97826826440569 0.000804692377569366 yes 36 0.00144941071538809 121 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1 0258-0098 57.368 µM 2.97784339592417 0.000805935395745791 yes 37 0.00145142131487134 41 6790032 YDR047W HEM12 SGTC_3084 9116877 49.47 µM 2.97383698451476 0.000817743980525461 yes 38 0.00147050636878403 27 27241325 SGTC_45 0kpi-0036 14.9 µM 2.9664322597406 0.000839988857729339 yes 39 0.00150638360686441 64 2795021 SGTC_2013 4024628 200 µM 2.96134332957621 0.000855598055570914 yes 40 0.00153150142149824 93 5230760 SGTC_2537 larixol 68.93 µM 2.9541091882127 0.000878246688559084 yes 41 0.00156786519350053 76 6708759 SGTC_2768 sulfasalazine 50.2 µM 2.95147247210197 0.000886637863480308 yes 42 0.00158131367747288 65 5384001 An antioxidant and salicylic acid derivative. SGTC_2168 5727979 200 µM 2.9323757314311 0.000949646535527244 yes 43 0.00168189755923211 59 695210 SGTC_2679 rapamycin 1 nM 2.93122680309795 0.000953565460549945 yes 44 0.0016881309313161 230 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_742 0kpi-0133 140 µM 2.88549963734705 0.00112213668595866 no 45 0.00195396455990772 67 2728852 SGTC_1260 0700-1617 7.75 µM 2.88410445358713 0.00112768498149221 no 46 0.00196264265506806 100 2853078 SGTC_1054 3429-0080 167 µM 2.85795075762711 0.00123645422878541 no 47 0.002131932772719 80 1162877 SGTC_2522 biochanin a 4.94 µM 2.85429683313635 0.00125239213352912 no 48 0.00215661049619425 52 5280373 A possible chelator. SGTC_2461 5755302 26.15 µM 2.82878697800514 0.0013690034469607 no 49 0.00233623942268689 100 2788904 SGTC_1751 st044839 27.194 µM 2.82184913863029 0.00140239016147201 no 50 0.00238738162743106 43 5291326 SGTC_674 0498-0004 451 µM 2.81900131096309 0.00141630863486378 no 51 0.00240866606879109 73 4231473 SGTC_3326 9140064 16.379 µM 2.81117370175587 0.0014552175877024 no 52 0.00246805647584605 69 1868434 SGTC_1520 flindersine 88 µM 2.7911016029049 0.00155948980280401 no 53 0.0026264490077581 99 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_48 0382-0018 55 µM 2.78171434825442 0.00161055562371517 no 54 0.00270363050527954 56 762596 SGTC_277 nystatin 15.5 µM 2.76037153409907 0.00173237567572089 no 55 0.00288678300143869 90 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.75963875699802 0.0017367033338864 no 56 0.0028932653895452 90 6708760 SGTC_1078 idebenone 36.1 µM 2.75896699103891 0.00174067931246377 no 57 0.00289921958101705 123 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2429 5902844 64.44 µM 2.75443799566795 0.00176770196880036 no 58 0.00293965144595064 117 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1726 st035556 14.5795 µM 2.7277735723272 0.00193468337933038 no 59 0.0031881679987171 126 5919439 SGTC_907 3448-6986 75.5 µM 2.71068688868037 0.00204908998376966 no 60 0.00335719989463207 101 590582 SGTC_2408 sulbentine 18.36 µM 2.70990872814358 0.00205444355118818 no 61 0.00336508627580859 125 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2468 5987765 72.9 µM 2.67423176916749 0.0023139532147173 no 62 0.00374503335840368 71 26772094 SGTC_2917 7979103 53.79 µM 2.65267750393638 0.00248477456012142 no 63 0.00399280638830546 119 2980565 SGTC_1523 st012844 44.7 µM 2.64559413060569 0.00254335270969461 no 64 0.00407737974555789 103 4274103 SGTC_948 3448-0295 75.3 µM 2.6364031971858 0.00262121985331301 no 65 0.00418950519226884 120 678569 SGTC_130 0136-0219 337.655 µM 2.55784960658502 0.00337979169689491 no 66 0.00526608153941957 110 234244 SGTC_2039 Aminomethylbenzodioxan 200 µM 2.53169122656148 0.00367310653038425 no 67 0.00567569511592097 70 15053 SGTC_1016 4226-1401 38 µM 2.52307740169567 0.00377457684181925 no 68 0.00581663960544114 114 2901613 SGTC_2301 7769476 200 µM 2.50973170002538 0.00393675689090483 no 69 0.00604114612470418 91 977820 SGTC_996 3970-0799 1.8 µM 2.49965422854425 0.00406332758804818 no 70 0.00621572873194719 237 6615648 YGL040C HEM2 SGTC_1817 st052116 64.4 µM 2.49101632597754 0.00417470378341016 no 71 0.00636891332991283 96 4361398 SGTC_887 0885-0007 9.62 µM 2.46131536829004 0.00457879791323412 no 72 0.00692143131176142 147 5719458 SGTC_2472 5377652 49.4 µM 2.45870837936071 0.00461588174685286 no 73 0.00697189150915377 182 1610903 SGTC_94 0334-0113 514.748 µM 2.45064738082094 0.0047322491814152 no 74 0.0071299785925086 133 6795178 SGTC_2115 tiliquinol 12.7705 µM 2.44093968191983 0.00487585607147576 no 75 0.00732455065205727 89 71208 A bioactive hydroxyquinoline. SGTC_1256 0570-0116 285 µM 2.41457625187477 0.00528564061353544 no 76 0.00787676258894931 129 410638 SGTC_3048 9093155 49.47 µM 2.41195669671916 0.00532798575788301 no 77 0.00793358297112338 72 25236002 SGTC_1490 4089-0339 670 nM 2.39638430211938 0.00558599734219455 no 78 0.00827885994489422 70 742542 SGTC_1442 4112-3290 3 µM 2.37675018912136 0.00592708594779921 no 79 0.00873295614540435 130 704353 SGTC_53 0973-0023 39.979 µM 2.3764920955027 0.00593168998754425 no 80 0.0087390679362731 123 674768 SGTC_3234 9132280 49.47 µM 2.36729479809242 0.00609784115127747 no 81 0.00895932679156836 146 17612295 SGTC_319 1348-1596 45.5 µM 2.34837328004036 0.00645268491982677 no 82 0.0094278070095498 139 5380505 SGTC_2998 9066762 71.4286 µM 2.3287622401476 0.00683962099166299 no 83 0.00993583240594349 173 4945196 SGTC_2206 7254556 146.969 µM 2.31362935116463 0.00715206718343469 no 84 0.0103440311227146 74 4398905 SGTC_700 3453-2283 142 µM 2.30009535334905 0.00744209778612115 no 85 0.0107214092399313 182 565664 SGTC_1178 0988-0033 191 µM 2.29631635713408 0.00752490988228764 no 86 0.0108288997580142 197 5392207 SGTC_501 nsc-95397 161 µM 2.29508816696953 0.00755199838797638 no 87 0.0108640360392845 110 262093 SGTC_3192 9110362 49.47 µM 2.29465422150993 0.00756158984000791 no 88 0.0108764741282859 121 16649480 SGTC_1877 wortmannin 25 µM 2.2934434636876 0.00758840784367805 no 89 0.0109112433799399 244 312145 A covalent inhibitor of PI 3-kinase. SGTC_2141 5621638 7.665 µM 2.29164508076131 0.00762839620065817 no 90 0.0109630659404773 127 2856238 SGTC_616 4092-0450 108 µM 2.29057228430433 0.00765233886165836 no 91 0.0109940817234272 154 787165 SGTC_3269 9137823 49.47 µM 2.28942214227312 0.00767808118071258 no 92 0.0110274184204002 135 17682936 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.2745601081106 0.0080176423393251 no 93 0.0114661657281316 183 23847180 SGTC_2928 9011484 9.79 µM 2.26804709554673 0.00817056274283483 no 94 0.0116631681808713 147 2994751 SGTC_1198 1612-1005 86.7 µM 2.25189217284243 0.00856097842522558 no 95 0.0121645434451084 148 6998509 SGTC_1839 st053978 48 µM 2.2502028344533 0.00860273493780627 no 96 0.0122180362289927 155 3788398 SGTC_3182 9108849 49.47 µM 2.23874004206751 0.00889081668450938 no 97 0.0125864177627588 168 17133045 SGTC_706 4262-0057 46.9 µM 2.23021677746127 0.00911046856060416 no 98 0.0128665274837819 183 883298 SGTC_438 sphingosine 6.67 µM 2.2287778585105 0.00914801582189442 no 99 0.0129143444274098 133 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_209 4077-0173 175.592 µM 2.22607211314231 0.00921898675875279 no 100 0.0130046757566827 87 15993494 SGTC_543 3844-1095 191 µM 2.22134363684185 0.00934417078050905 no 101 0.0131638477090957 209 4230703 SGTC_3147 9097027 49.47 µM 2.20928890904309 0.00967006416844041 no 102 0.0135772760673139 167 25236841 SGTC_155 k072-0202 43.6 µM 2.19418207876853 0.0100924599144132 no 103 0.0141111612047235 144 5857737 SGTC_1820 st053765 18.6 µM 2.19395320881611 0.0100989811465578 no 104 0.0141193867863716 168 3690829 SGTC_534 k292-0788 63.4 µM 2.18317518622048 0.0104102738490709 no 105 0.0145114556833069 177 4146317 SGTC_1912 st060209 90.8 µM 2.18070365619522 0.0104828247444533 no 106 0.0146026712241339 181 688787 SGTC_19 0279-0214 38.434 µM 2.16043551871802 0.0110945935695301 no 107 0.01536948515073 275 3566274 YBR002C RER2 SGTC_689 0833-0039 98 µM 2.15698648591868 0.0112017328478877 no 108 0.0155033587154764 175 5374726 SGTC_1030 k029-0042 36.7 µM 2.14465631935301 0.0115921410794197 no 109 0.0159901678806742 218 6080581 SGTC_603 3794-0023 45.9 µM 2.12831050984437 0.0121278732931801 no 110 0.0166556736474016 148 3802260 SGTC_252 miconazole 1.30953 nM 2.12278405947306 0.0123137939071455 no 111 0.0168859756071967 201 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_208 k072-0098 12.366 µM 2.12040330282934 0.0123946451332582 no 112 0.0169860242057401 265 5948901 SGTC_2754 granisetron 64.02 µM 2.12030908477258 0.01239785424355 no 113 0.0169899940152946 210 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2534 helenine 20.12 µM 2.11513708762559 0.0125751223821468 no 114 0.0172091325271516 145 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_453 enantio-paf c16 10 µM 2.10668955719807 0.01286937737297 no 115 0.0175722489967605 427 13871343 A lipid and platelet activating factor SGTC_1161 k007-0610 110 µM 2.10402836405328 0.0129633005420712 no 116 0.0176879864341735 327 5843850 SGTC_1195 1502-0147 41.1 µM 2.10176072293075 0.0130438009433154 no 117 0.0177871206737136 225 817940 SGTC_2771 fluoxetine 41.05 µM 2.08476798671818 0.0136609044297696 no 118 0.0185451829746676 187 3386 A selective serotonin reuptake inhibitor. SGTC_493 zm226600 134 µM 2.06539052217301 0.014395201163736 no 119 0.0194430323133979 207 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1687 st020778 55.3625 µM 2.05423603325863 0.0148331145505721 no 120 0.0199764262252903 399 4259299 SGTC_875 0709-0210 25.7 µM 2.0525228480051 0.0149013771669866 no 121 0.0200594384543218 230 6251364 SGTC_1614 st002383 48.6 µM 2.04470948003476 0.0152161396691533 no 122 0.020441754225343 200 1947235 SGTC_304 1310-0298 97 µM 2.04085994416343 0.015373307649985 no 123 0.0206323751185087 270 1550234 SGTC_1833 st055984 71 µM 2.03053242187941 0.0158018603007059 no 124 0.0211512245048454 188 676288 SGTC_1935 st074532 41.6 µM 2.02425907094915 0.0160671507010214 no 125 0.0214717512561485 261 2829742 SGTC_696 1560-0013 611 µM 2.01752144113862 0.0163563169550525 no 126 0.0218205628980627 212 1650269 SGTC_1986 st071812 45 µM 2.01738160915919 0.0163623651788997 no 127 0.0218278524909277 152 11838594 SGTC_1734 st037168 69.4 µM 2.01436559849606 0.0164932851318616 no 128 0.0219855817005186 233 708907 SGTC_1477 0139-0234 16 µM 2.01405978671833 0.0165066098412132 no 129 0.0220016284274679 188 620880 SGTC_1701 st028638 40.4 µM 1.99943774769155 0.0171545585304385 no 130 0.0227805055665734 223 3490878 SGTC_349 k015-0014 24 µM 1.99316444619833 0.0174391410975982 no 131 0.0231217214533409 215 2196908 SGTC_2757 clomiphene 4.22 µM 1.99219028726743 0.0174836925464234 no 132 0.0231750917582827 259 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2447 5741742 33.78 µM 1.98738793943755 0.0177047423957892 no 133 0.0234397115800804 234 1776504 SGTC_3328 9140624 29.0385 µM 1.97806613042375 0.0181406333058961 no 134 0.0239606234236163 218 4904392 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.96727106789435 0.0186568118749062 no 135 0.0245759843331439 256 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2185 6113692 200 µM 1.96466846123088 0.0187831124691655 no 136 0.0247263112701749 202 874150 SGTC_1266 0828-0227 32.9 µM 1.96260139476904 0.0188839418172693 no 137 0.0248462542693353 230 3913820 SGTC_2453 5731132 22.18 µM 1.95038866564599 0.0194891092717944 no 138 0.0255649058824466 236 1362040 SGTC_2247 cerulenin 830 nM 1.94713172683223 0.0196532529066412 no 139 0.0257594721030863 225 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2016 5121758 140 µM 1.94494788086131 0.0197639708452167 no 140 0.0258906257312023 303 2795203 SGTC_550 4123-0385 25.7 µM 1.93692390740733 0.0201753324507735 no 141 0.0263773227731625 238 5731123 SGTC_1368 1852-0141 284 µM 1.93492769753273 0.0202787917805762 no 142 0.0264995843920219 246 2838987 SGTC_1949 st076024 69.1 µM 1.93039075387734 0.0205156057577887 no 143 0.0267792198535908 258 2921930 SGTC_3181 9108277 49.47 µM 1.92230248783076 0.0209436004580752 no 144 0.0272838535731413 227 17097298 SGTC_2395 5646831 180.19 µM 1.91829289803813 0.0211585565091027 no 145 0.0275369412231137 251 6808628 SGTC_2372 9071633 200 µM 1.91803349300228 0.0211725273843919 no 146 0.0275533822053922 221 21321366 SGTC_3040 9091894 49.47 µM 1.91128292413645 0.0215388485600696 no 147 0.0279841161310546 184 25236966 SGTC_1391 3442-0225 151 µM 1.91003740939596 0.0216070187467291 no 148 0.028064198416275 199 5227075 SGTC_2910 7948405 25.97 µM 1.90418003744853 0.0219300573073183 no 149 0.0284433703313139 219 2971328 SGTC_2686 alizarin 95.37 µM 1.90132595634252 0.0220889339141126 no 150 0.0286296656386607 244 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_651 3253-0966 34.4 µM 1.89991163210356 0.0221680236624951 no 151 0.0287223586343134 268 781462 SGTC_2180 6301957 200 µM 1.89937907178573 0.0221978665841774 no 152 0.0287573265669148 194 845462 SGTC_1043 0916-0009 19.3 µM 1.89741539302723 0.0223081977770379 no 153 0.0288865678113493 306 3101130 SGTC_444 curcumin 90.4 µM 1.88521693156292 0.0230039919925081 no 154 0.0297002778992147 265 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3266 9136860 49.47 µM 1.88180618042511 0.0232017782909855 no 155 0.0299311681821232 277 4871271 YPR165W RHO1 SGTC_1187 1391-0724 117 µM 1.87924901066575 0.0233510035224158 no 156 0.0301052501907626 282 6997986 SGTC_1171 0368-0077 21.4 µM 1.8779173346442 0.0234290336017014 no 157 0.0301962373036468 229 3239779 SGTC_2380 9035439 200 µM 1.87665047396803 0.0235034693211411 no 158 0.030283007345107 285 6462575 SGTC_3217 9129673 49.47 µM 1.87235215170696 0.0237575059497065 no 159 0.0305789500496061 281 17248312 SGTC_675 1309-0189 238 µM 1.87173778595535 0.023794003668043 no 160 0.0306214445965703 241 4246530 SGTC_3148 9097893 49.47 µM 1.86941064239456 0.0239326803543182 no 161 0.0307828525351293 281 17174100 SGTC_3114 9122766 49.47 µM 1.86775723678614 0.0240316205778766 no 162 0.0308979582799244 247 17176985 SGTC_425 3825-7017 13.1 µM 1.86108260095443 0.0244345334535246 no 163 0.0313662564323207 306 3397440 SGTC_591 4299-0174 154 µM 1.86107040730399 0.0244352746780166 no 164 0.0313671172900305 225 5509088 SGTC_2438 5259590 200 µM 1.84791086133235 0.0252462908360647 no 165 0.0323076195141469 260 1201127 SGTC_2769 toremifene 3.73 µM 1.84750710223933 0.0252715267209568 no 166 0.0323368398715644 255 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.84736694962833 0.0252802915261255 no 167 0.0323469879218187 244 279621 SGTC_1633 st005664 67.9 µM 1.84288798872151 0.0255617390861774 no 168 0.032672683177606 303 2063822 SGTC_2788 5282734 71.43 µM 1.84221375625017 0.0256043326468259 no 169 0.0327219445187293 318 743706 SGTC_1587 estradiol valerate 56.1 µM 1.84176512523286 0.0256327071068822 no 170 0.0327547566958154 264 13791 A steroid. SGTC_1887 st057648 70.8 µM 1.84153236403441 0.0256474388684322 no 171 0.0327717911745595 252 688672 SGTC_1611 st001856 99.4 µM 1.84093976629086 0.0256849771540744 no 172 0.0328151930305676 264 647478 SGTC_1646 st011709 75.6 µM 1.83976404102983 0.0257595899808112 no 173 0.0329014434155287 212 5757843 SGTC_1140 3229-1848 2.98 µM 1.82587559897861 0.0266547757769536 no 174 0.0339345012428352 219 2849525 SGTC_2280 7785178 200 µM 1.82098012972889 0.0269764464803243 no 175 0.0343049386961556 234 2954328 SGTC_2089 5281248 129.67 µM 1.81553807420162 0.0273378287093064 no 176 0.034720630177732 292 2737878 SGTC_1871 st057448 67.3 µM 1.81153655242315 0.0276061200081762 no 177 0.0350289181166518 298 691747 SGTC_1567 st069303 68.4 µM 1.80853985949499 0.0278084743910119 no 178 0.0352612594993646 307 5581319 SGTC_2121 5257820 149.641 µM 1.80577353184179 0.0279963686493284 no 179 0.0354768607178316 286 791256 SGTC_562 3772-2733 112 µM 1.80469263167137 0.0280700721691574 no 180 0.0355613967450499 359 2876874 YIL048W NEO1 SGTC_2132 5317594 122.667 µM 1.80222607977613 0.0282388645118226 no 181 0.035754921545972 232 794577 SGTC_1433 4060-0023 7.6 µM 1.79633832246397 0.0286451961776848 no 182 0.0362203632803594 271 3840627 SGTC_1989 st071868 50.2 µM 1.79425223156974 0.0287903251778151 no 183 0.0363864593763085 287 16414057 SGTC_2997 9067075 71.4286 µM 1.79246282726686 0.0289153003395866 no 184 0.036529429287956 327 27209819 SGTC_1159 4092-0538 61.2 µM 1.7905763471428 0.0290475433835847 no 185 0.0366806527436903 310 717301 SGTC_3133 9127736 49.47 µM 1.78789577887661 0.0292363164009954 no 186 0.0368964120301951 272 27243420 SGTC_1047 2043-3044 82 µM 1.78710968797735 0.0292918679286331 no 187 0.036959880988829 317 669592 SGTC_1763 st044482 94.5 µM 1.78613461431132 0.0293608962827536 no 188 0.0370387324008712 298 88505 SGTC_2507 purpurin 79.67 µM 1.78326238892382 0.0295650150041706 no 189 0.0372718003997576 320 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_220 paclitaxel 373.376 µM 1.78168585967998 0.0296775530390338 no 190 0.0374002370410704 220 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1971 st069429 63.5 µM 1.77895921006115 0.0298730295598144 no 191 0.0376232247969162 246 1246522 YGL099W LSG1 SGTC_2328 6201408 200 µM 1.77671777666951 0.0300345191273474 no 192 0.0378073429912766 287 2890418 SGTC_2067 5224629 34.075 µM 1.76477079557223 0.0309075255656731 no 193 0.0388011473857782 317 2835000 SGTC_1410 3909-8106 77.9 µM 1.76344579161641 0.0310056290508065 no 194 0.0389126661994861 239 1039210 SGTC_272 doxorubicin 8.13 µM 1.76097072322546 0.0311895736820815 no 195 0.0391216791763416 345 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_268 camptothecin 39.6153 µM 1.75949949078578 0.0312993413375558 no 196 0.0392463533299895 423 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1283 0922-0125 16.4 µM 1.75697447302609 0.0314884757799459 no 197 0.0394610801800003 316 3360884 SGTC_358 0075-0058 9.45 µM 1.75294746129481 0.0317920701367486 no 198 0.0398055128911152 412 1069125 SGTC_330 1488-0319 80.1 µM 1.74593566612689 0.0323264550126238 no 199 0.0404110657332678 284 6846614 SGTC_1357 1503-1303 39.5 µM 1.73878208739785 0.0328792624101582 no 200 0.041036550272354 342 292895 SGTC_1046 2001-0062 216 µM 1.72751039811913 0.0337660997170093 no 201 0.0420380196843077 318 739778 SGTC_2154 5570129 200 µM 1.72734269654392 0.0337794413293581 no 202 0.042053067702376 331 673366 SGTC_54 0159-0055 9 µM 1.72457761146498 0.0340000455394493 no 203 0.0423018105330134 310 3319099 SGTC_2088 5278280 127.392 µM 1.72323576975722 0.0341075266728722 no 204 0.0424229488288641 340 791502 SGTC_923 1900-2434 73.3 µM 1.71733664891524 0.0345833632119087 no 205 0.0429588397289866 319 5910570 SGTC_1893 st059353 36.1 µM 1.71497803644054 0.0347751340132742 no 206 0.0431746269201495 335 3112488 SGTC_1658 st012944 20 µM 1.71359668693822 0.0348878517203738 no 207 0.0433014112233151 342 24207260 SGTC_518 1021-0119 62.6 µM 1.71345754621433 0.034899222169847 no 208 0.0433141986155231 347 1097762 SGTC_143 4032-1194 15.74 µM 1.71085049704661 0.0351128308456374 no 209 0.0435543574681965 425 1806963 SGTC_2482 5981709 142.65 µM 1.70600818247171 0.0355124326077514 no 210 0.0440032780707032 359 877755 SGTC_525 k781-2675 26.7 µM 1.69414616792462 0.0365070907009241 no 211 0.0451187555969388 370 3651118 YDL195W SEC31 SGTC_1310 1188-0297 994 nM 1.69258097731769 0.0366400218046448 no 212 0.0452676272360236 339 1588352 SGTC_1502 4534-4282 27.7 µM 1.69178359872111 0.0367078949836289 no 213 0.0453436209526801 274 3278949 SGTC_2235 salicylic acid 500 µM 1.69168713028871 0.036716113383224 no 214 0.0453528217764949 247 338 A COX inhibitor and kinase inhibitor. SGTC_3146 9095609 49.47 µM 1.68952449912237 0.0369007489930048 no 215 0.0455594804910077 309 17173999 SGTC_1741 st038134 10.228 µM 1.68893256503448 0.0369514177468862 no 216 0.0456161768655548 379 1272587 SGTC_2231 micatex 6.853 µM 1.68873841438281 0.036968049160881 no 217 0.0456347852680681 267 20737 An antifungal of unknown mechanism. SGTC_2017 5132927 60.65 µM 1.68827369792584 0.0370078827499048 no 218 0.0456793508823865 354 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1852 st056254 31.4 µM 1.67832240593478 0.0378693193158385 no 219 0.0466420881391334 310 442583 SGTC_939 1165-0479 45.3 µM 1.67685371243556 0.0379978319843268 no 220 0.046785545706006 353 1377347 SGTC_282 k297-0036 65.7 µM 1.67649183603465 0.0380295512319914 no 221 0.0468209470009685 281 5061378 SGTC_2316 5844804 197.44 µM 1.66928817635515 0.0386654746855395 no 222 0.0475301411569696 443 776813 SGTC_106 0092-0003 11.579 µM 1.66884947889934 0.0387044801605831 no 223 0.047573607030524 254 1072148 SGTC_2978 9011784 42.97 µM 1.66560719077538 0.038993753503048 no 224 0.0478958389898257 414 2994934 SGTC_743 1275-0778 158 µM 1.66468514367926 0.0390763382496112 no 225 0.0479877942313158 363 2849257 YMR203W TOM40 SGTC_1832 st054113 55 µM 1.66419919797698 0.039119920082792 no 226 0.0480363141548515 290 1251267 SGTC_1415 3966-0071 78.1 µM 1.65981067680509 0.0395152974654121 no 227 0.048476272591994 315 2893185 SGTC_362 0310-0100 9.03 µM 1.65941050435606 0.0395515115477149 no 228 0.0485165505108301 359 790235 SGTC_1597 7-benzyloxygramine 47.5 µM 1.65654840588255 0.039811308176293 no 229 0.0488054054130774 514 260807 SGTC_420 mitomycin C 81.9 mM 1.64903747814925 0.0404996873139326 no 230 0.049569978447397 368 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_404 fumagillin 50 µM 1.64374316602222 0.0409906950696397 no 231 0.0501146327345951 374 12015870 A methionine aminopeptidase binder. SGTC_1901 st060216 58.6 µM 1.63447874196767 0.0418615099162652 no 232 0.0510791831598286 342 688792 SGTC_545 4218-0007 221 µM 1.63411423391561 0.041896076002077 no 233 0.0511174333148343 335 2840508 SGTC_1919 st067113 52.3 µM 1.63295274592304 0.0420063733947804 no 234 0.0512394677113354 385 1268243 SGTC_409 arachidonic acid 100 µM 1.63250629748466 0.0420488315857849 no 235 0.0512864364642593 352 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3094 9117742 49.47 µM 1.63062532078272 0.0422280980757099 no 236 0.0514847014921294 384 17149698 SGTC_809 3998-0021 90 µM 1.62954802734859 0.0423310477250797 no 237 0.0515985282198199 305 715485 SGTC_1920 st075728 45.7 µM 1.62936728658063 0.0423483397718966 no 238 0.0516176448591436 355 3400306 SGTC_384 k007-0144 5.16 µM 1.62365962291096 0.0428973560278441 no 239 0.0522242364579066 420 6824886 SGTC_3099 9120367 49.47 µM 1.62317538811921 0.0429441977201684 no 240 0.0522759587660298 348 24824940 SGTC_2541 muurolladie-3-one 83.07 µM 1.62233948197731 0.0430251550343027 no 241 0.052365339665257 358 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1753 st043925 64 µM 1.61980828110867 0.0432710534701178 no 242 0.0526367334258434 369 670181 SGTC_847 0342-0274 5.54 µM 1.61816669581555 0.0434311342612883 no 243 0.052813339044077 355 18097 SGTC_3270 9137563 49.47 µM 1.61775567546534 0.0434712900593752 no 244 0.0528576310853743 306 17015724 SGTC_1684 st024538 14.6195 µM 1.61549342132923 0.0436928441252514 no 245 0.0531019419246918 356 6732859 SGTC_260 nsc-65238 3.989 µM 1.60863758289419 0.0443698403876258 no 246 0.0538478056433963 329 3246252 SGTC_2284 7945075 39.21 µM 1.60505977311023 0.0447264821928183 no 247 0.0542403254794029 411 1245402 SGTC_924 2046-0044 21.3 µM 1.60321251452644 0.0449115215229774 no 248 0.0544438717349388 363 3623589 SGTC_568 1193-0097 7.48 µM 1.60253220439014 0.0449798230596432 no 249 0.0545189859913911 454 3646150 SGTC_183 3914-0051 30.55 µM 1.59839440628589 0.0453970509186918 no 250 0.0549776143708533 357 1596232 SGTC_355 1311-2252 105 µM 1.59441366761322 0.0458013741956074 no 251 0.0554217065900795 396 5338538 SGTC_2848 9016370 25.97 µM 1.59322418353605 0.0459227499967728 no 252 0.0555549539323395 425 7894410 SGTC_229 benomyl 22.8748 µM 1.58993736715394 0.0462594832055384 no 253 0.0559244618561864 407 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_950 1165-0508 94.1 µM 1.58663846601838 0.0465994452515975 no 254 0.0562972750998505 379 6148369 SGTC_793 0488-0545 106 µM 1.58213981102631 0.0470662736723182 no 255 0.0568088285156402 373 292548 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.57994027275925 0.047295882160731 no 256 0.0570602726162303 334 616764 SGTC_2471 5466956 24.79 µM 1.56865252088911 0.0484883632398561 no 257 0.0583644636818297 336 724419 SGTC_665 3914-0008 307 µM 1.56787480941566 0.048571401061858 no 258 0.0584551758621512 393 1069549 SGTC_2214 7179297 48.276 µM 1.56603740304133 0.0487680362949544 no 259 0.0586699305154634 318 769744 SGTC_2931 9014674 55.67 µM 1.56098030650528 0.0493125223920575 no 260 0.059264198771622 401 2996810 SGTC_102 gallobenzophenone 83.616 µM 1.56020326178146 0.0493966135864084 no 261 0.0593559275400036 422 70837 SGTC_2065 5221596 34.26 µM 1.5578312027376 0.049654024320961 no 262 0.059636633604702 390 788581 SGTC_988 1497-1057 103 µM 1.55656967392907 0.0497913580587756 no 263 0.0597863442744751 406 3533044 SGTC_1439 4092-1168 46 µM 1.55077312722557 0.0504262863097342 no 264 0.0604780313560024 370 2886240 SGTC_2478 5763493 32.33 µM 1.54798867787559 0.0507335679995552 no 265 0.0608125112404338 391 1365576 YLR208W SEC13 SGTC_419 nsc-638432 893 µM 1.54497456378815 0.0510678734106198 no 266 0.0611762080292545 405 368090 SGTC_1101 ebselen 5.29 µM 1.53960436719124 0.051667842077308 no 267 0.0618284101550667 408 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_529 4076-0302 30.3 µM 1.53798862835729 0.051849448025651 no 268 0.0620256976239839 404 5816522 SGTC_1468 k284-1086 134 µM 1.53728486694177 0.0519287078931117 no 269 0.0621117828246626 484 15996457 SGTC_1429 4049-0205 9.46 µM 1.5354207291041 0.0521391183732104 no 270 0.062340257561545 410 22774478 SGTC_851 0394-0702 453 µM 1.5339776272448 0.0523024699182902 no 271 0.0625175784367318 431 762646 SGTC_1388 3346-4487 254 µM 1.53284490168145 0.0524309729613403 no 272 0.0626570371362338 438 3345614 SGTC_3252 9135871 49.47 µM 1.53175986072063 0.0525543012985439 no 273 0.0627908522710305 390 17682838 SGTC_3346 9158254 43.5805 µM 1.53074216822752 0.0526701837946331 no 274 0.062916563792769 421 17639500 SGTC_558 k064-0027 21.3 µM 1.52990250874815 0.052765946627717 no 275 0.0630204311531634 403 5088526 SGTC_2386 9075165 157.42 µM 1.52808293720755 0.0529739420603237 no 276 0.0632459736535568 360 16452277 SGTC_1743 st037606 46.3785 µM 1.52295968213863 0.0535630760860223 no 277 0.0638843963239999 401 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1554 st069299 38.7 µM 1.52241616129671 0.0536258800638235 no 278 0.0639524189430515 406 24207999 SGTC_2245 6637752 200 µM 1.52194026078118 0.0536809183807213 no 279 0.0640120249917729 330 681890 SGTC_1780 st038448 24.544 µM 1.51855796004596 0.0540733744978257 no 280 0.0644368999291935 398 728868 YDL195W SEC31 SGTC_2687 chenodiol 100 µM 1.51469335573451 0.0545245694772272 no 281 0.0649250389095887 396 5702181 A cholesterol synthesis inhibitor. SGTC_226 1,3-diallylurea 8.28947 mM 1.51305926171518 0.0547162443844741 no 282 0.0651323031876535 351 74537 YKL182W FAS1 SGTC_1109 tnp00067 928.257 nM 1.50901600302819 0.0551927978538138 no 283 0.0656473466186714 395 676295 SGTC_1007 4101-0031 70 µM 1.50870850015424 0.0552291750202117 no 284 0.0656866461761247 426 1146276 SGTC_3044 9093193 49.47 µM 1.50847464709748 0.0552568521896247 no 285 0.0657165453292742 442 25236277 SGTC_347 4534-1311 26.2 µM 1.50607115788563 0.0555419472044235 no 286 0.0660244538629995 408 2862016 SGTC_551 k048-0028 34.9 µM 1.50331616435791 0.0558701635782223 no 287 0.0663787668731647 449 6836383 SGTC_1036 k216-0215 33.5 µM 1.50088394088449 0.0561611967589747 no 288 0.066692791251223 494 622330 SGTC_2875 9039966 71.43 µM 1.49932404561194 0.0563484778528349 no 289 0.066894793648146 349 6463691 SGTC_2101 5377231 179.231 µM 1.4958003471909 0.0567733451949116 no 290 0.0673528454345446 388 2844213 SGTC_2150 5556613 200 µM 1.49144168465737 0.0573023740466557 no 291 0.0679227854404355 455 743190 SGTC_2710 st078562 53.7235 µM 1.48555142240055 0.0580234536863674 no 292 0.0686989061259267 406 17250908 SGTC_1953 st076800 12.1 µM 1.47751340744571 0.0590189415210967 no 293 0.0697690335100227 473 297591 SGTC_2657 nystatin 74.44 µM 1.47735474220419 0.0590387258168976 no 294 0.0697902855380799 441 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_786 4544-0069 423 µM 1.47586967932315 0.0592241536892851 no 295 0.0699894402877892 455 748821 YLR208W SEC13 SGTC_1899 st063254 59.6 µM 1.47342437806314 0.0595304735891848 no 296 0.0703183204510047 372 3093813 SGTC_960 1222-0186 7.7 µM 1.47283571718013 0.0596043995466509 no 297 0.070397669438153 457 3126296 SGTC_2905 7799065 20.05 µM 1.46632075749635 0.0604273815287128 no 298 0.0712804615342976 391 1296806 SGTC_2536 dehydroabietamide 32.04 µM 1.46596192772299 0.0604729666613757 no 299 0.0713293296113279 481 3983547 SGTC_2795 7780010 54.55 µM 1.46232986981721 0.0609358930978026 no 300 0.0718254185248664 419 953673 SGTC_80 0159-0065 512.242 µM 1.45851504026842 0.0614250931748833 no 301 0.0723493162811156 298 1548079 SGTC_2208 7283366 200 µM 1.45531390047938 0.0618379584533637 no 302 0.0727911900579699 447 898663 SGTC_740 k014-0057 261 µM 1.454369330729 0.0619601967973334 no 303 0.0729219690713871 502 4012779 SGTC_3165 9101544 49.47 µM 1.44935511193443 0.0626122552637744 no 304 0.073619218764986 459 5002184 SGTC_2352 9027995 87.8 µM 1.44786454661944 0.0628071190383561 no 305 0.073827468307194 385 2997347 SGTC_2171 5739187 198.077 µM 1.44455439931783 0.0632415491773652 no 306 0.0742915446240327 385 2262761 SGTC_1494 4358-1428 177 µM 1.44229182807989 0.0635398370720458 no 307 0.0746100322797764 474 1564571 SGTC_2726 cimetidine 79.27 µM 1.43980428092398 0.0638690471886865 no 308 0.0749613898497117 372 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_701 4424-0219 185 µM 1.42926550764313 0.0652785176815495 no 309 0.076463967895839 521 2911779 SGTC_636 0kpi-0074 126 µM 1.4257606879816 0.065752566741635 no 310 0.0769687160105644 432 616434 SGTC_2215 7188065 200 µM 1.42570107852379 0.0657606523158668 no 311 0.0769773225424855 372 940217 SGTC_2502 avocadyne acetate 18.59 µM 1.42432910594024 0.0659469631551358 no 312 0.0771756128916208 527 3952079 SGTC_564 3555-0129 330 µM 1.42286815376795 0.0661458066315598 no 313 0.0773871898292355 359 563260 SGTC_848 0368-0089 85.6 µM 1.42215957693876 0.0662424148632733 no 314 0.0774899653430442 477 762535 SGTC_719 2810-4230 27.3 µM 1.41994119037395 0.0665455791186649 no 315 0.0778124014560507 407 721079 SGTC_997 3996-0078 137 µM 1.41900842326955 0.0666733711612877 no 316 0.077948280171478 485 735687 SGTC_528 3492-0019 172 µM 1.41735649481947 0.0669001564946274 no 317 0.0781893627393899 704 2869262 SGTC_775 4577-0580 57.3 µM 1.41560267111576 0.067141583154321 no 318 0.0784459344112877 462 2006902 SGTC_2773 thioridazine 9.09 µM 1.41557617518262 0.0671452356723981 no 319 0.0784498154623689 478 5452 An antipsychotic. SGTC_2224 6650123 117.647 µM 1.41434051158877 0.0673157451271038 no 320 0.0786309737925905 416 2908370 SGTC_476 mead acid 10 µM 1.41255241014031 0.0675630779777191 no 321 0.0788936851275017 387 5312531 An omega 9 fatty acid. SGTC_2618 avocadyne 43.43 µM 1.40669871183777 0.0683776840369837 no 322 0.0797583739452038 440 3015189 SGTC_1132 3456-3614 2.5 µM 1.40669844142602 0.0683777218420058 no 323 0.0797584140544473 583 3125502 SGTC_481 bay k-8644 50 µM 1.4058630678362 0.0684945885796789 no 324 0.0798823949830942 458 2303 A calcium channel antagonist. SGTC_2134 5324836 1.464 µM 1.40525798224908 0.0685793347664335 no 325 0.0799722889833477 400 699272 SGTC_207 4185-0010 4.486 µM 1.4033859232608 0.0688420410728442 no 326 0.0802508941768576 560 3761753 SGTC_3009 9080819 71.4286 µM 1.40050522727238 0.0692478041570343 no 327 0.0806810395846544 467 17027216 SGTC_2640 pentamidine 10.38 µM 1.39906312028766 0.0694516243197793 no 328 0.0808970278740252 530 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1564 D-Arginine 115 µM 1.38950855843471 0.0708137079399495 no 329 0.0823390801319161 486 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2584 androsterone 48.74 µM 1.38723313219335 0.071141095310345 no 330 0.0826853427633527 651 2754130 A steroid. SGTC_1333 1482-0047 286 µM 1.38704466976056 0.0711682632369096 no 331 0.0827140710718178 526 3811116 SGTC_2682 pyrogallin 40.03 µM 1.38662518741735 0.0712287625897914 no 332 0.0827780419114598 541 822798 An ATP competetive kinase inhibitor. SGTC_462 ag-879 158 µM 1.3771755691685 0.0726021100848813 no 333 0.0842289866197194 529 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1860 st056228 74.6 µM 1.37435419943364 0.0730160568688542 no 334 0.0846658738126573 474 688679 SGTC_877 0771-0151 33.1 µM 1.36979105287636 0.0736893742861688 no 335 0.0853760678933943 539 6166523 SGTC_3107 9121808 49.47 µM 1.36978685815405 0.0736899954167917 no 336 0.0853767227936858 389 662681 SGTC_813 k007-0158 173 µM 1.36696636348939 0.0741085449920894 no 337 0.0858179244506743 575 6523916 SGTC_2673 kobusone 100 µM 1.36603876952479 0.0742465921430145 no 338 0.0859633975179206 468 6710676 An epoxy ketone and protein crosslinker. SGTC_1727 st034309 9.9045 µM 1.36465860590842 0.0744523553565727 no 339 0.0861801877794841 582 870305 SGTC_1476 4112-3294 3.34 µM 1.36352020692548 0.074622402219316 no 340 0.0863593102406096 487 704369 SGTC_2032 5185112 25.99 µM 1.36119304886032 0.0749709405281188 no 341 0.086726345147162 459 5718189 SGTC_3058 9093861 49.47 µM 1.3608224553918 0.0750265587128517 no 342 0.086784901882005 501 17217477 SGTC_2204 7233102 200 µM 1.36041345870052 0.0750879769260822 no 343 0.0868495609220781 430 2172480 SGTC_1827 berberine 7.24 µM 1.36034612795733 0.0750980915232829 no 344 0.0868602088127819 459 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2964 9083345 53.42 µM 1.35851210528643 0.075374002886964 no 345 0.0871506220423511 463 17741579 SGTC_1337 1486-1011 40.3 µM 1.35848569066213 0.0753779823539609 no 346 0.0871548100270785 492 X1337 SGTC_1297 1068-0111 14.1 µM 1.35825550921649 0.07541266687193 no 347 0.0871913111862163 481 767057 SGTC_760 0568-0725 82.9 µM 1.35768169322163 0.0754991843612604 no 348 0.087282354092762 513 3916171 SGTC_909 3448-9333 149 µM 1.35748456152205 0.0755289244743771 no 349 0.0873136478154867 479 3344074 SGTC_2629 bisabolol 100 µM 1.35396333625904 0.0760616562518423 no 350 0.0878740375415244 536 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1031 k035-0009 16 µM 1.34754524888787 0.0770400107494611 no 351 0.0889023452592659 573 5180959 SGTC_1951 sophoraflavanone G 9.2 µM 1.34675139719516 0.0771616848320482 no 352 0.0890301564170654 566 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.34357733597574 0.0776496343069484 no 353 0.0895425512104333 620 368090 SGTC_3355 9151058 44.0485 µM 1.34291366130106 0.0777519567158725 no 354 0.0896499661557884 494 17015728 SGTC_2005 4024620 188 µM 1.34244221843928 0.077824703829847 no 355 0.0897263267942415 499 236743 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.34243814355808 0.0778253328392037 no 356 0.089726987022433 510 97141 SGTC_2339 9000433 200 µM 1.34196357865611 0.0778986143172475 no 357 0.0898039025893696 480 2988954 SGTC_2897 9048598 12.99 µM 1.34195571560669 0.0778998289563621 no 358 0.0898051774133553 494 6467404 SGTC_1778 st046819 58.9 µM 1.34075336237948 0.0780857308147486 no 359 0.0900002714055039 586 671715 SGTC_3314 9135860 59.4275 µM 1.33785343132545 0.0785354882357676 no 360 0.0904721101063699 532 25252478 SGTC_3054 9094397 49.47 µM 1.33610925495324 0.0788069409418418 no 361 0.0907567827043448 556 2598354 SGTC_890 0929-0006 47.2 µM 1.3355868909986 0.0788883765769805 no 362 0.0908421686071576 492 1378169 SGTC_2253 7938677 135.83 µM 1.33558080668946 0.0788893254856805 no 363 0.0908431635027728 503 2301972 SGTC_2152 5568786 200 µM 1.33465877142291 0.0790332260474398 no 364 0.0909940265633616 512 5399883 SGTC_1238 0333-0287 48.8 µM 1.33289966852672 0.079308317719168 no 365 0.0912823656879728 518 7226 SGTC_2792 7535235 81.82 µM 1.32935329256108 0.0798651091151116 no 366 0.0918657198733574 483 1281891 SGTC_2014 4013930 200 µM 1.32746493759512 0.0801627899815067 no 367 0.0921774654926777 584 64556 SGTC_2563 tomatine 8.54 µM 1.32731196759032 0.0801869408932803 no 368 0.0922027533231407 604 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2349 9023730 187.07 µM 1.32579727167864 0.08042637807326 no 369 0.0924534284885891 517 4126287 SGTC_1286 0929-0070 131 µM 1.32575873033691 0.0804324775767134 no 370 0.0924598134745398 552 1420408 SGTC_1923 st058458 19.1 µM 1.3240562259767 0.0807022625765486 no 371 0.0927421860092711 588 3534982 SGTC_2715 st079500 56.4 µM 1.32144723832469 0.0811170174005976 no 372 0.0931761420148125 485 28246688 SGTC_74 000s-0487 160.283 µM 1.31830040544971 0.0816194120132002 no 373 0.0937015526450164 523 677548 SGTC_3211 9128781 49.47 µM 1.31609616543276 0.0819727156009889 no 374 0.0940708839249841 540 17194361 SGTC_2486 5283202 22.39 µM 1.31561927654812 0.082049304485098 no 375 0.0941509301451787 517 1377751 SGTC_1360 1598-0022 39.8 µM 1.31427175867291 0.0822660087402909 no 376 0.0943773837826678 624 761525 SGTC_3167 9103034 49.47 µM 1.31199884581354 0.0826325088624821 no 377 0.0947602619920922 449 5127859 SGTC_2145 5634607 200 µM 1.310605986817 0.082857709532561 no 378 0.0949954577682216 467 308662 SGTC_2412 st077135 33.4 µM 1.30817437748575 0.0832519639833059 no 379 0.0954070853083379 549 13258915 SGTC_1338 1486-1223 76 µM 1.30634367213678 0.0835497189421184 no 380 0.09571785593182 582 3444526 SGTC_2553 4-methylesculetin 85.09 µM 1.30560819938791 0.0836695649287124 no 381 0.0958429152785533 538 5319502 SGTC_1303 1160-0052 261 µM 1.30504518878267 0.0837613952865327 no 382 0.095938730451309 534 3562476 SGTC_1997 st073024 93.8 µM 1.3007159193117 0.0844700555710806 no 383 0.0966778555855795 540 686268 SGTC_1216 1165-0504 9.65 µM 1.29856679558275 0.0848235130814383 no 384 0.0970463196692269 563 6304004 SGTC_2986 9022445 71.43 µM 1.29697344357425 0.0850862801283 no 385 0.0973201621778539 537 6459286 SGTC_1769 st044406 64.4 µM 1.29690026450448 0.0850983630631025 no 386 0.097332752750273 594 670903 SGTC_868 0527-0199 213 µM 1.29619683674255 0.0852145748716982 no 387 0.0974538395445144 572 2849450 SGTC_1398 3558-0053 112 µM 1.2944335854871 0.0855064004295455 no 388 0.0977578479937719 469 4532369 SGTC_2741 miltefosine 3.04 µM 1.28694631788743 0.0867539150474211 no 389 0.0990564998217807 444 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1085 doxorubicin 7.67 µM 1.28487229053477 0.0871018795614547 no 390 0.0994184576801374 604 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2317 5986382 200 µM 1.28097253165338 0.0877589721323609 no 391 0.100101657189655 573 877883 SGTC_250 brefeldin a 552.239 µM 1.27911845959032 0.088072669190334 no 392 0.100427672041181 468 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_521 r062-0005 13.8 µM 1.27817440548605 0.0882327179276282 no 393 0.100593969252818 551 2832033 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.27481619754688 0.0888038037152394 no 394 0.101187153108593 613 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2729 fluphenazine 10.66 µM 1.27384811080314 0.0889689433397929 no 395 0.101358625447794 562 3372 An atypical antipsychotic. SGTC_2707 st078556 66.6 µM 1.27159285555167 0.0893545390871194 no 396 0.101758908258116 546 17250899 SGTC_2008 4012253 172 µM 1.27120946064896 0.0894202140739293 no 397 0.101827070893995 581 603940 SGTC_953 1188-0045 9.7 µM 1.27035397269122 0.0895668873415534 no 398 0.101979285349322 576 6144426 SGTC_2021 4019055 173 µM 1.27016939749349 0.0895985561790755 no 399 0.102012147976157 733 44827708 YER133W GLC7 SGTC_192 3455-0609 60.9 µM 1.2685936828891 0.0898692514020398 no 400 0.102293009274756 553 3769639 SGTC_1652 st011932 78 µM 1.26430088832546 0.0906098024021866 no 401 0.103061025439026 551 1551076 SGTC_2747 doxorubicin 7.63 µM 1.26355929582488 0.0907381922394342 no 402 0.103194125574518 377 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1706 st031321 9.9705 µM 1.25894205410572 0.0915406007752964 no 403 0.104025631258396 577 6103185 SGTC_1596 piperlongumine 63 µM 1.25829428845771 0.091653592213446 no 404 0.104142672996029 641 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1504 k297-0033 30 µM 1.25665529809412 0.091939947009178 no 405 0.104439240779179 461 4388117 SGTC_3213 9129884 49.47 µM 1.25253562554942 0.0926626368512492 no 406 0.105187377651813 496 17190742 SGTC_2521 angolensin 13.4 µM 1.25046399315642 0.0930276348698212 no 407 0.105565050316034 543 821428 A flavenoid. SGTC_299 1273-0059 1.44 µM 1.24877032625222 0.093326828380753 no 408 0.105874545098541 565 2848077 SGTC_672 1441-0018 53.7 µM 1.24871292069219 0.0933369817603489 no 409 0.105885046668953 551 251141 SGTC_162 k030-0015 37.8 µM 1.2469375284705 0.0936514002074129 no 410 0.106210202416861 584 1809920 YMR134W ERG29 SGTC_3264 9137442 49.47 µM 1.24617995859509 0.0937858021246043 no 411 0.106349167528664 546 17015726 SGTC_283 0987-0079 11.7 µM 1.24616859165834 0.0937878198382186 no 412 0.1063512536263 624 411556 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.24527055504018 0.0939473291314877 no 413 0.106516157661946 599 4213774 SGTC_2911 7942208 15.64 µM 1.24471667022247 0.0940458099398933 no 414 0.106617958026067 521 1243384 SGTC_2123 5259487 200 µM 1.24324901955887 0.0943071267481247 no 415 0.106888042039111 618 2173474 SGTC_3025 9087895 49.47 µM 1.24301847786472 0.0943482235688834 no 416 0.106930512230093 640 17173641 SGTC_1349 flufenamic acid 69 µM 1.24189140735365 0.0945493275252239 no 417 0.107138315420275 544 3371 A non-steroidal anti-inflammatory. SGTC_1961 st076550 68.7 µM 1.24120576537577 0.0946718215838782 no 418 0.107264872777805 532 1579337 SGTC_3090 9117696 49.47 µM 1.23975487059086 0.0949314182308258 no 419 0.107533037531048 560 7923821 SGTC_601 0986-0029 62.9 µM 1.23857800471461 0.0951423700511295 no 420 0.107750908916665 624 24747981 SGTC_1449 4112-4002 201 µM 1.23662032888065 0.0954940455758528 no 421 0.10811403457932 569 2059539 SGTC_886 0866-0150 153 µM 1.23574512940137 0.0956515749010381 no 422 0.10827665836185 621 271463 SGTC_1166 k206-0078 225 µM 1.22608203536548 0.0974035849504259 no 423 0.110083902732271 631 5404595 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.22528981824179 0.0975482586895212 no 424 0.110233021633817 571 5355888 SGTC_329 k048-0121 21.3 µM 1.2204944996208 0.098427339095268 no 425 0.111138736699034 581 6832902 SGTC_1287 0971-0001 34.6 µM 1.21904924588985 0.0986934179851487 no 426 0.111412750911665 652 4665869 SGTC_3331 9141060 1.957 µM 1.21562549723854 0.0993258483256106 no 427 0.112063808363981 569 4906567 YPR165W RHO1 SGTC_684 1140-0066 328 µM 1.21477556498798 0.0994833047457362 no 428 0.112225851400395 659 6813534 SGTC_1625 st003711 30.1 µM 1.21373014239927 0.0996772273473255 no 429 0.112425395041698 591 24207034 YER133W GLC7 SGTC_1011 4112-3381 17.4 µM 1.21279037724424 0.0998517864330975 no 430 0.112604987697689 620 2877139 SGTC_2752 diclazuril 33.15 µM 1.21218269370432 0.0999647809803746 no 431 0.112721227338314 786 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2825 7998094 58.44 µM 1.21023722806635 0.10032715481042 no 432 0.11309393836266 589 2987815 SGTC_702 1488-0190 94 µM 1.20981640795621 0.100405665188255 no 433 0.113174674354436 612 949357 SGTC_1882 5615643 20 µM 1.20568621390528 0.101178595895315 no 434 0.113969251315694 565 2253075 SGTC_1846 st056244 14.8 µM 1.20170172573253 0.101928359586307 no 435 0.114739556147339 660 5393182 SGTC_193 1273-0060 1.558 µM 1.20000310842357 0.102249215858028 no 436 0.115069066610323 524 2847393 YHR072W ERG7 SGTC_597 k018-0003 82.8 µM 1.19721906536095 0.102776688775944 no 437 0.115610590307856 683 6786234 SGTC_1239 0337-0584 35.4 µM 1.19599283594488 0.103009640002558 no 438 0.115849677383291 677 914301 YML130C ERO1 SGTC_2098 5376439 882.5 nM 1.19261369030531 0.103653572736911 no 439 0.11651035084722 664 2844116 SGTC_1463 k081-0032 34.1 µM 1.19192464530534 0.103785235440807 no 440 0.116645396808141 507 977755 SGTC_2356 9061756 188.97 µM 1.19089536846995 0.103982135532943 no 441 0.116847331495685 585 20104043 SGTC_2751 anetholtrithion 17.25 µM 1.18372229643242 0.105361865987757 no 442 0.118261504955799 625 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2797 7859098 81.82 µM 1.18172465153921 0.105748457378313 no 443 0.118657486790185 637 972681 SGTC_810 3825-7150 143 µM 1.17828572482694 0.106416370977665 no 444 0.119341358429046 682 22330411 YGL099W LSG1 SGTC_857 0438-0306 1.35 µM 1.17828389325262 0.106416727518575 no 445 0.119341723399018 639 4686136 SGTC_1714 st033236 13.627 µM 1.17249710058639 0.107547515928202 no 446 0.120498767753769 655 2916566 SGTC_390 dec-rvkr-cmk 16.7 µM 1.1704769922529 0.107944294014795 no 447 0.120904533900163 670 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2793 7325131 81.82 µM 1.16994992003064 0.108047991699224 no 448 0.121010561484292 603 4176441 SGTC_1866 st057638 64 µM 1.16987912985847 0.108061924620178 no 449 0.121024806850122 640 688802 SGTC_1588 farnesol 29.9 µM 1.16653064562106 0.108722451644484 no 450 0.121699982826938 657 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1995 st072814 61.1 µM 1.16533351285325 0.108959302993021 no 451 0.1219420093448 628 5769371 SGTC_1698 5-fluorocytosine 1.055 µM 1.16123337129943 0.109773321387796 no 452 0.122773503532386 646 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1632 st005650 90 µM 1.15778030973724 0.110462251053209 no 453 0.123476850348301 633 2759605 SGTC_1209 2323-2347 50.3 µM 1.15749408700857 0.110519494932879 no 454 0.123535276863006 639 5412760 SGTC_2909 7941780 10.49 µM 1.15629773581627 0.110758992587299 no 455 0.12377969707944 671 1243215 SGTC_365 0121-0052 13.6 µM 1.15401843144128 0.111216315471878 no 456 0.124246306251585 719 3101739 SGTC_1234 0326-0494 15.5 µM 1.15158326901947 0.11170640200706 no 457 0.124746179910452 658 1547813 SGTC_2705 st078069 42.8 µM 1.1502065919534 0.11198414657786 no 458 0.125029395914931 607 1530061 SGTC_519 k048-0011 62.8 µM 1.14923998299694 0.112179454742846 no 459 0.125228519106392 639 6836379 SGTC_1962 st076595 64.5 µM 1.14766255159289 0.112498705272093 no 460 0.125553948152213 668 279619 SGTC_1865 st057639 52.2 µM 1.1420403728659 0.113641834809519 no 461 0.126718619221642 668 688818 SGTC_2085 5307070 144.047 µM 1.14181035983962 0.113688777890916 no 462 0.126766427587379 614 2840351 SGTC_2868 9035608 32.47 µM 1.13964656949796 0.114131059999917 no 463 0.127216787721686 658 6462614 SGTC_751 0833-0568 350 µM 1.13905117533655 0.11425297421548 no 464 0.1273409050342 671 6954252 SGTC_3330 9141424 71.43 µM 1.13433618140582 0.115221702618185 no 465 0.12832677886519 710 27261020 SGTC_1519 esterone 74 µM 1.13207663834213 0.115688005399433 no 466 0.12880110779756 673 698 A steroid. SGTC_348 k064-0012 10.7 µM 1.12989950005923 0.11613856877982 no 467 0.129259287327804 626 5066323 SGTC_3285 9112818 20.8695 µM 1.12772277410671 0.116590290500922 no 468 0.129718508246929 718 17017947 YPR165W RHO1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.12742315455366 0.116652566013451 no 469 0.129781806933916 681 229346 A bile salt which induces apoptosis. SGTC_2699 st077704 54.6 µM 1.12699032614608 0.116742570445518 no 470 0.129873285556614 674 645852 SGTC_1372 2752-0194 270 µM 1.1269605140715 0.116748771524295 no 471 0.12987958800485 624 823334 SGTC_2402 5553605 200 µM 1.12570284184958 0.117010587159697 no 472 0.130145660233581 710 6758546 SGTC_3059 1327-0034 3 µM 1.12396198537991 0.117373675701346 no 473 0.130514576617305 679 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1393 3470-5649 58.2 µM 1.12051325470843 0.118095328067962 no 474 0.131247553730882 575 4108395 SGTC_2166 5933061 31.504 µM 1.1164583830132 0.118947823351555 no 475 0.132112987371704 668 2877375 SGTC_1155 4088-0394 48.2 µM 1.11562834892404 0.119122864029494 no 476 0.132290626095772 681 2326248 SGTC_800 3448-7362 155 µM 1.11519775440507 0.119213741006491 no 477 0.132382844081711 927 15991913 SGTC_1322 1348-1070 12 µM 1.11258068144487 0.119767126847722 no 478 0.132944280606537 648 6758089 SGTC_897 1000-0139 31.4 µM 1.10992355149966 0.12033083347468 no 479 0.13351598539497 702 6151020 SGTC_955 1216-0110 33 µM 1.10913021514188 0.120499500476399 no 480 0.133687005959685 717 3619719 SGTC_1628 st004252 77.7 µM 1.10867044056887 0.120597326860261 no 481 0.13378618907695 715 692968 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.10522787500951 0.121331579634663 no 482 0.134530430617662 790 65057 A dermal irritant. YDR527W RBA50 SGTC_204 PMA1.184 62.41 µM 1.10405791343994 0.121581830871807 no 483 0.134784008168877 756 2252213 YGL008C PMA1 SGTC_2658 polymyxin b sulfate 77.05 µM 1.10050233729362 0.122344583587447 no 484 0.135556655907775 724 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1058 3448-5425 97.3 µM 1.09696984217768 0.12310570468852 no 485 0.136327287793437 675 7279705 SGTC_227 fluconazole 33.516 µM 1.0930600376452 0.123951984434837 no 486 0.137183720198161 757 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_317 4495-0002 170 µM 1.09305141169438 0.123953856017729 no 487 0.13718561374415 654 15991618 SGTC_2222 6885208 172.143 µM 1.09291337411602 0.12398380888718 no 488 0.137215917818376 686 609514 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.09118357294138 0.124359589122411 no 489 0.137596057325542 713 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2414 st077232 92.9 µM 1.09086423101028 0.124429049639789 no 490 0.137666314139778 663 729801 SGTC_35 0133-0054 64.071 µM 1.08967414130753 0.124688146657793 no 491 0.13792835540508 653 99677 SGTC_3105 9121040 49.47 µM 1.08940527529467 0.124746734242565 no 492 0.137987603062466 473 41448907 SGTC_916 4466-0038 42 nM 1.08908389042907 0.124816791252368 no 493 0.138058446614279 848 5722064 YGL116W CDC20 SGTC_2050 5263056 171 µM 1.08901583000766 0.124831630915232 no 494 0.138073452500344 782 763468 YGL055W OLE1 SGTC_1546 5-methoxyflavanone 78.7 µM 1.08774284525291 0.125109415364205 no 495 0.138354323731057 761 147795 SGTC_1473 k844-0725 134 µM 1.08607387886401 0.125474262580903 no 496 0.138723153932367 800 54682906 SGTC_407 eburnamonine 100 µM 1.08252190872483 0.126253217202191 no 497 0.139510342871885 654 3195 SGTC_3118 9124250 49.47 µM 1.07972451845706 0.126869058576843 no 498 0.14013243614276 651 1504786 SGTC_1770 st043884 66.3 µM 1.0794733876131 0.12692444678469 no 499 0.140188375523156 726 670149 SGTC_1213 1315-0166 115 µM 1.07837472175595 0.12716696111807 no 500 0.140433281601342 613 768401 SGTC_15 0266-0086 27.098 µM 1.0765375141698 0.127573217649254 no 501 0.140843466375968 820 1712902 YIL048W NEO1 SGTC_1972 st070201 17.4 µM 1.07501801635286 0.127909901015106 no 502 0.141183331130426 733 2829099 SGTC_1795 st049545 62.3 µM 1.07489897650363 0.127936303374191 no 503 0.141209980137367 717 5291882 SGTC_650 1328-0195 38 µM 1.07286413379293 0.128388205514997 no 504 0.14166604019165 752 2780821 SGTC_302 1094-0063 18.9 µM 1.07252329147827 0.128464008714673 no 505 0.14174252908283 658 5440289 SGTC_3043 9092303 49.47 µM 1.07070823725678 0.128868199261868 no 506 0.142150318919012 667 25236084 SGTC_766 1391-0721 126 µM 1.07047098584028 0.128921097388076 no 507 0.142203681022255 739 1020919 YIL115C NUP159 SGTC_1470 k295-0292 231 µM 1.06972789561893 0.129086875951971 no 508 0.142370903065478 764 5045612 SGTC_1207 2099-0101 141 µM 1.0679089586004 0.129493292405241 no 509 0.142780790521722 777 5837381 SGTC_622 1348-1566 26.3 µM 1.06659721402162 0.129786933323316 no 510 0.143076879547356 785 7340407 SGTC_569 4130-2812 160 µM 1.06580622213646 0.129964223699091 no 511 0.143255623817746 608 743552 SGTC_1409 3909-8004 61.9 µM 1.06518178039826 0.130104302423917 no 512 0.14339683842455 763 2119279 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.06501689135003 0.130141308811179 no 513 0.143434142999877 787 676296 Flavone; oxidizing agent. SGTC_101 0490-5701 117.494 µM 1.06478278263017 0.130193862823055 no 514 0.143487119120511 693 4661669 SGTC_2701 st077767 14.721 µM 1.06467095902162 0.130218970782889 no 515 0.143512428182633 775 5721188 SGTC_82 0054-0107 293.755 µM 1.06396932880528 0.130376585560516 no 516 0.143671297076156 740 3104697 SGTC_774 k060-0086 136 µM 1.05893486934405 0.131511401076814 no 517 0.144814721322854 831 5911235 SGTC_1330 1469-0054 61.8 µM 1.0582144510645 0.131674346239124 no 518 0.14497884221458 779 7102664 SGTC_2213 7173844 200 µM 1.0581415902595 0.131690833747073 no 519 0.144995447847083 763 892728 SGTC_998 3996-0085 177 µM 1.05687109039107 0.131978561325724 no 520 0.145285212005142 814 715391 SGTC_301 4119-0100 24.5 µM 1.05534966136634 0.132323686434287 no 521 0.145632718110743 780 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1966 st070145 16.1 µM 1.05467509661276 0.132476905412425 no 522 0.14578697257166 729 3748532 SGTC_2297 7971671 152.32 µM 1.0490264742297 0.13376471752843 no 523 0.147082966950051 735 909016 SGTC_1199 1638-0010 4.46 µM 1.04801598995908 0.133995999140034 no 524 0.147315619945776 765 3111136 SGTC_758 0868-0029 16 µM 1.04782243116674 0.13404033259333 no 525 0.147360212880566 774 762687 SGTC_3201 9113999 49.47 µM 1.04587188560327 0.134487655597023 no 526 0.147810093107088 724 16649224 SGTC_2125 5246583 200 µM 1.04533089084586 0.134611904475117 no 527 0.147935032645135 858 835267 SGTC_912 3474-0017 2.18 µM 1.04499099810842 0.134690007055214 no 528 0.148013565012037 775 3360550 SGTC_1065 prochlorperazine maleate 2.48 µM 1.03944324512003 0.135969199816834 no 529 0.149299320265897 777 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_337 1315-0038 354 µM 1.03916704377205 0.13603310255218 no 530 0.149363527378759 761 1626437 SGTC_116 0155-0182 31.788 µM 1.0387081472596 0.136139319613312 no 531 0.149470245451756 870 771486 SGTC_3008 9078912 71.4286 µM 1.03818243673474 0.136261071317608 no 532 0.149592563901007 735 16648731 SGTC_3153 9100258 49.47 µM 1.03626918796093 0.136704798217279 no 533 0.150038288286059 689 25236848 SGTC_2103 5378138 10 µM 1.03566451378559 0.136845241451771 no 534 0.150179341548893 855 244142 SGTC_1169 aniline yellow 25.8 µM 1.03509856241739 0.136976780144749 no 535 0.150311441937812 738 6051 A DNA damaging agent. SGTC_2614 arthonioic acid 13.39 µM 1.0323323356132 0.137620950952734 no 536 0.150958229035721 705 6710684 SGTC_2266 7929956 200 µM 1.03166813643627 0.137775930252268 no 537 0.151113804559031 769 2967153 SGTC_50 0929-0078 56.389 µM 1.03145970596717 0.137824588408115 no 538 0.151162647258003 726 1377751 SGTC_1448 4255-0083 152 µM 1.03096056545669 0.137941160564804 no 539 0.151279656384465 804 5399660 SGTC_880 0833-0487 87.2 µM 1.02855284895577 0.138504417112231 no 540 0.151844922211421 744 76075 SGTC_854 0422-0053 192 µM 1.02777346846996 0.138687079174422 no 541 0.152028199653724 751 3596728 SGTC_428 3448-4153 16.5 µM 1.02687783089883 0.138897190763622 no 542 0.152238997227717 680 3834874 SGTC_1885 st057546 99.9 µM 1.0264977173127 0.138986428777092 no 543 0.152328519522082 810 702008 SGTC_2564 betulinic acid 100 µM 1.02582161984037 0.139145250390221 no 544 0.152487836675419 834 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2750 bromebric acid 70.15 µM 1.02344717024729 0.139704009183696 no 545 0.153048233190653 827 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1651 st011928 86.1 µM 1.02179043957608 0.140094775707121 no 546 0.153440047617248 778 720198 SGTC_778 3456-2434 196 µM 1.01854697172204 0.1408619479255 no 547 0.154209045143283 883 5539063 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.01845919042513 0.14088275022964 no 548 0.154229892677168 791 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1376 2910-0861 41.3 µM 1.01747524577715 0.141116066830375 no 549 0.154463701195609 818 1112859 SGTC_1014 4130-3005 69.3 µM 1.01722112870418 0.141176366560739 no 550 0.154524123473604 794 743608 SGTC_3304 9125678 46.087 µM 1.01628326778219 0.141399063853417 no 551 0.154747257056584 769 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2949 9072542 2.23 µM 1.01426383637169 0.141879390500575 no 552 0.155228437600122 789 16457352 SGTC_1786 berberine 21.6 µM 1.01324712773847 0.142121634776578 no 553 0.155471067500338 752 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3060 1327-0027 12.5 µM 1.00808890493284 0.143354960948168 no 554 0.156705891776698 763 16000455 YPR107C YTH1 SGTC_1481 3346-2004 36 µM 1.00808407942973 0.143356118094703 no 555 0.156707049965352 816 2770522 SGTC_310 1273-0058 1.06 µM 1.00741878610134 0.143515714558322 no 556 0.156866783661688 937 2734232 SGTC_3082 9117008 49.47 µM 1.00590571366521 0.143879130226852 no 557 0.157230463753978 796 41448529 SGTC_1682 st012968 530 nM 1.00491054502541 0.144118491868902 no 558 0.157469963156942 705 24207270 SGTC_2634 4'-methoxyflavone 100 µM 1.00341958966989 0.14447760417993 no 559 0.157829228092366 734 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2281 7943571 200 µM 1.00144403362515 0.1449543657102 no 560 0.158306092351546 872 1244024 SGTC_2493 resveratrol 26.09 µM 0.997291746001611 0.145959887666105 no 561 0.159311459496587 747 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3144 9087057 49.47 µM 0.993482167142362 0.146886532076667 no 562 0.160237518351598 789 17249618 SGTC_850 0388-0143 75.9 µM 0.991656640989562 0.147331969717027 no 563 0.160682524447694 763 67273 SGTC_1220 1838-0075 193 µM 0.99125389527069 0.147430363480727 no 564 0.16078080980773 827 5529645 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.990901463294498 0.147516501339193 no 565 0.160866848887744 866 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3140 9094243 49.47 µM 0.989668765911286 0.147818049926178 no 566 0.161168023198675 873 19291112 SGTC_858 0438-0351 2.77 µM 0.987477100184518 0.14835520472053 no 567 0.161704401865607 853 2799119 SGTC_2732 terfenadine 20 µM 0.984585142004929 0.149065989699914 no 568 0.162413945428183 776 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1815 st051655 58.2 µM 0.980248144272199 0.150136193302184 no 569 0.163481822413053 825 5984156 SGTC_826 1683-5028 118 µM 0.978898981533899 0.150470156482015 no 570 0.163814947736657 814 722377 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.976959316976618 0.150951155284075 no 571 0.164294646858544 853 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3284 9108171 64.8615 µM 0.976877307688556 0.150971514503959 no 572 0.164314948653065 777 8687505 SGTC_166 k072-0058 166.424 µM 0.976012216907277 0.151186388972006 no 573 0.164529205117479 836 5846229 SGTC_1748 st037455 53.6035 µM 0.972507471825626 0.152058991503882 no 574 0.165399074778514 800 580690 SGTC_511 blebbistatin 171 µM 0.971279853441718 0.152365430257024 no 575 0.165704469196744 828 3476986 A myosin inhibitor. SGTC_1696 st025591 34.7925 µM 0.971025750544722 0.152428910725167 no 576 0.16576772784664 835 2787147 SGTC_1424 4048-1941 275 µM 0.970132668276084 0.152652161473767 no 577 0.16599018358804 922 X1424 SGTC_2770 toltrazuril 17.5 µM 0.969588011364179 0.152788420043551 no 578 0.166125945540657 880 68591 Kills coccidiodes. SGTC_1678 st019265 80.2 µM 0.969398744206893 0.152835788496072 no 579 0.166173139330343 859 5367020 SGTC_1385 3091-4834 14.1 µM 0.968117507994032 0.15315670336184 no 580 0.166492843465758 775 4072814 SGTC_315 k915-0449 187 µM 0.967357587541707 0.153347253626078 no 581 0.166682652264753 921 20970215 YNL149C PGA2 SGTC_1145 3546-0597 10.2 µM 0.966370574745785 0.153594981736769 no 582 0.16692939133741 848 875334 SGTC_2072 5231554 129 µM 0.965052353122862 0.153926252289624 no 583 0.167259295104806 906 789545 SGTC_1515 3460-0031 42.1 µM 0.96277573248198 0.154499482170725 no 584 0.167830040808509 780 2876596 SGTC_1804 st050076 49.1 µM 0.961946783977541 0.154708552951724 no 585 0.168038168107012 842 3895976 SGTC_2999 9069765 71.4286 µM 0.95924546513462 0.155391154643023 no 586 0.168717550662553 861 2097066 SGTC_2003 4023581 200 µM 0.957236658290476 0.155900050604631 no 587 0.16922390905386 819 16641307 SGTC_2867 9039098 71.43 µM 0.957055359803193 0.155946033386213 no 588 0.169269656775917 804 6463460 SGTC_3244 9134489 49.47 µM 0.953722090381312 0.156793044399276 no 589 0.170112167615471 827 16584271 SGTC_1861 st057647 17.4 µM 0.952368572948367 0.157137846899774 no 590 0.170455045974738 855 688668 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.951205221741622 0.157434603589356 no 591 0.170750104109196 783 1241132 A phosphatase inhibitor. SGTC_940 3232-1287 54.8 µM 0.949839779647447 0.157783380771715 no 592 0.171096834837935 864 1585493 YIL048W NEO1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.949337712192961 0.157911752221201 no 593 0.171224439455073 862 2333 A French combination drug. SGTC_934 2950-0684 338 µM 0.949187933992843 0.157950061637005 no 594 0.171262518611117 897 1121253 SGTC_2690 usnic acid 100 µM 0.948544903016924 0.158114601772057 no 595 0.171426062374771 914 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3126 9127922 49.47 µM 0.942796834521188 0.159590425809894 no 596 0.172892415586067 842 45595682 SGTC_467 ro 31-8220 72.8 µM 0.939429221665752 0.160459239565708 no 597 0.173755207866877 875 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2254 7938975 95.19 µM 0.937862917156744 0.160864382944383 no 598 0.174157431220628 937 2969277 SGTC_1164 k060-0068 93.7 µM 0.9356471241715 0.161438663879702 no 599 0.174727451582435 929 5963676 SGTC_3246 9135460 32.98 µM 0.933057453485423 0.162111537231973 no 600 0.175395152489843 799 41446951 SGTC_714 4296-0578 26.1 µM 0.932715128442496 0.162200619919325 no 601 0.175483535853132 854 1589775 SGTC_170 4197-0004 226 µM 0.932375486707472 0.162289035827339 no 602 0.175571254318819 805 218692 SGTC_1824 st053723 68.6 µM 0.932101907197791 0.16236027715499 no 603 0.175641931252527 897 675225 SGTC_338 4055-0136 114 µM 0.9277076037186 0.163507362230023 no 604 0.176779631580845 874 2900563 SGTC_3354 9151612 71.43 µM 0.927076071752972 0.163672648274268 no 605 0.176943519408027 903 27261949 SGTC_713 1488-1073 324 µM 0.924495424856483 0.164349188136824 no 606 0.177614216215307 892 3312542 SGTC_1162 k048-0130 20.1 µM 0.922477004417766 0.164879597023069 no 607 0.178139909835003 868 6797406 SGTC_2780 5215298 71.43 µM 0.922467358216756 0.16488213455063 no 608 0.178142424521554 928 2834131 SGTC_2611 pyromycin 23.93 µM 0.921914455401204 0.165027623318071 no 609 0.178286599209669 857 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2389 9091542 195.52 µM 0.921234324412013 0.165206704400933 no 610 0.178464050685618 883 3626624 YOL127W RPL25 SGTC_2893 9048488 25.97 µM 0.919955158015984 0.165543854385739 no 611 0.178798096452197 865 6467338 SGTC_1634 st006576 41 µM 0.919715777854935 0.165606997231008 no 612 0.178860652676588 892 3915356 SGTC_1125 tnp00248 1.32998 µM 0.919235612950487 0.165733700365947 no 613 0.178986173702782 1009 24207736 SGTC_3083 9117465 49.47 µM 0.916068644232089 0.166570951139666 no 614 0.179815446240071 899 16420915 SGTC_1284 0929-0043 16 µM 0.915179835355633 0.166806415087555 no 615 0.180048614377342 897 1239883 SGTC_3299 9121982 43.1275 µM 0.914179514764529 0.16707167751888 no 616 0.18031126318946 893 17594604 YPL160W CDC60 SGTC_1094 duloxetine 25.4 µM 0.91234711417314 0.167558293842904 no 617 0.18079301000041 882 60834 A selective serotonin reuptake inhibitor. SGTC_2426 5582046 32.21 µM 0.911289783231745 0.167839495953349 no 618 0.181071354081211 901 2251934 SGTC_75 0159-0059 199.013 µM 0.910956843380099 0.167928105727036 no 619 0.181159056586712 883 5377270 SGTC_2390 9097792 176.6 µM 0.91038421489712 0.168080577489603 no 620 0.181309959729544 856 4497149 SGTC_2593 nobiletin 86.24 µM 0.91014419362908 0.168144513592081 no 621 0.181373235250643 830 72344 An anti-infammatory. SGTC_62 0180-0423 3.232 µM 0.909175777506187 0.168402636112137 no 622 0.181628674009438 882 30102 YGL099W LSG1 SGTC_1438 4092-1045 4 µM 0.908824942720593 0.168496210783403 no 623 0.181721269093735 914 1351342 SGTC_1879 gemcitabine 100 µM 0.907709928442671 0.168793829362652 no 624 0.182015748501981 898 60750 A nucleoside analog which inhibits DNA replication. SGTC_1025 k007-0731 70 µM 0.903976294127186 0.169792865140601 no 625 0.1830039858276 894 6256118 SGTC_820 1582-0060 59.9 µM 0.903667971924105 0.169875534315031 no 626 0.183085743494663 902 3848840 SGTC_2157 5649910 96.377 µM 0.902702390087837 0.170134598765019 no 627 0.183341933808785 894 2858091 SGTC_2205 7238770 200 µM 0.899868656989767 0.170896346848361 no 628 0.184095075850046 930 279867 SGTC_2641 levomentholum 100 µM 0.898482813570445 0.171269674764303 no 629 0.184464101867776 883 16666 SGTC_2508 celastrol 40.54 µM 0.896788750673124 0.171726740636285 no 630 0.184915825901668 862 122724 Celastrol is a natural product and antioxidant. SGTC_77 0828-0286 12.516 µM 0.895756223199875 0.172005703043215 no 631 0.185191487551037 943 745345 SGTC_1661 st013063 9.66 µM 0.895636422824242 0.172038088747925 no 632 0.185223488076914 977 721395 SGTC_2692 st077426 47.7 µM 0.894874441207959 0.172244166782801 no 633 0.185427105477888 947 25238571 SGTC_2131 toluylene red 5.2905 µM 0.893108893554606 0.17272226440585 no 634 0.185899430377996 888 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1917 st066507 28.5 µM 0.89183662427774 0.173067309704852 no 635 0.186240253983493 921 3156428 SGTC_524 r073-0010 27.8 µM 0.888632034558569 0.173938353483982 no 636 0.187100434393047 884 2772106 SGTC_671 0560-0003 407 µM 0.887840492163852 0.174153932242781 no 637 0.187313279152664 897 3238678 SGTC_625 k213-0058 121 µM 0.887678795313387 0.174197991706978 no 638 0.187356777639965 1059 3655420 SGTC_2974 9094440 9.66 µM 0.887306643671736 0.174299423203118 no 639 0.1874569148366 937 25236134 SGTC_681 1642-0006 26.6 µM 0.887161795876732 0.174338912222821 no 640 0.187495898890483 935 4446530 SGTC_463 ikarugamyin 104 µM 0.883891613957609 0.175231955519945 no 641 0.188377362301344 937 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_648 0375-0473 33.3 µM 0.880456960019688 0.17617303169591 no 642 0.189305905658097 952 1713139 SGTC_2981 9013952 38.96 µM 0.879322065548739 0.176484688330012 no 643 0.189613337566236 886 2996344 SGTC_13 0199-0087 65 µM 0.876759062014566 0.177189804272729 no 644 0.190308759592678 997 4589825 SGTC_515 4092-1064 102 µM 0.876675214929013 0.177212901724834 no 645 0.190331536330088 1008 717353 SGTC_892 0929-0076 29 µM 0.876337281814275 0.177306011819982 no 646 0.190423351529466 962 5751038 SGTC_1371 2421-0008 32.7 µM 0.875445568962872 0.177551852108605 no 647 0.190665757220028 898 2827552 SGTC_2669 eugenol 100 µM 0.872937697685885 0.178244410957409 no 648 0.191348518631766 910 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3180 9109287 49.47 µM 0.871236333225597 0.178715217589835 no 649 0.191812562637867 880 18891271 SGTC_506 n9-isopropylolomoucine 153 µM 0.870120298839618 0.179024474789107 no 650 0.192117332835888 958 6610355 SGTC_679 0422-0091 41.4 µM 0.869424869760155 0.179217350899374 no 651 0.192307392552983 995 627384 YHR062C RPP1 SGTC_1405 3909-7894 12 µM 0.869339193000238 0.179241122247063 no 652 0.192330815835751 960 7104060 SGTC_2114 5491910 81.25 µM 0.866552607627455 0.180015351969531 no 653 0.193093595022933 950 2849228 SGTC_1311 1190-0148 100 µM 0.865649153112982 0.18026681944069 no 654 0.193341295894686 1063 1961333 SGTC_2941 9056145 11.23 µM 0.864348083505512 0.180629346195067 no 655 0.19369835171334 870 2119517 SGTC_2722 naftopidil 47.16 µM 0.862950575684829 0.181019253139639 no 656 0.194082320845774 968 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1529 apigenin 74 µM 0.862557380015312 0.181129050358457 no 657 0.194190435970253 966 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1616 st002734 56.1 µM 0.861385729610162 0.181456473077155 no 658 0.19451281649702 974 4026101 SGTC_1947 st076332 61.6 µM 0.861244009593144 0.181496102445645 no 659 0.194551832941647 962 24208416 SGTC_884 0851-0618 334 µM 0.861203457163946 0.181507443175498 no 660 0.194562998166144 979 9642473 SGTC_1316 1272-0050 65.9 µM 0.86117650419574 0.181514980979949 no 661 0.194570419292192 952 7340392 SGTC_1403 3909-7815 62.9 µM 0.860189191767251 0.181791232839648 no 662 0.194842380790724 922 6615483 SGTC_615 k087-0205 167 µM 0.858590156681475 0.182239203418106 no 663 0.195283335331404 923 9642773 SGTC_1790 st045711 43.5 µM 0.858331993016191 0.182311592743437 no 664 0.195354584097633 963 585119 SGTC_63 0099-0242 26.702 µM 0.854964930573181 0.183257364865697 no 665 0.196285281325 1011 3898502 YLR359W ADE13 SGTC_42 0133-0086 60.653 µM 0.854545762816361 0.183375318432567 no 666 0.196401332276013 930 162923 Model of phenazepam hydroxylation. SGTC_459 nigericin 15.3 µM 0.854262673845094 0.183455006279359 no 667 0.196479731922329 1036 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_361 000s-0510 1.45 µM 0.852216071179275 0.184031754614851 no 668 0.197047089167378 943 660 SGTC_21 0849-0113 22.993 µM 0.850931586175562 0.184394308287136 no 669 0.197403678787369 959 1560156 SGTC_2948 9070189 9.45 µM 0.850028759665483 0.184649402268165 no 670 0.197654548468077 881 6473636 YDL196W YDL196W SGTC_1489 4065-0444 182 µM 0.842815942548038 0.186695257704872 no 671 0.199665695159204 967 2877968 SGTC_2737 bleomycin 30.5 nM 0.841885498042229 0.186960188624786 no 672 0.199926024239337 1034 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_122 0236-0016 402.397 µM 0.83968854386739 0.187586662704255 no 673 0.200541519480946 1082 6808838 SGTC_586 0957-0265 8.15 µM 0.839226961154055 0.1877184503612 no 674 0.200670980272852 908 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_364 0083-0097 67.7 µM 0.838654285622633 0.18788203588467 no 675 0.200831669152597 967 5207356 SGTC_3188 9110789 49.47 µM 0.83642961157235 0.188518351752539 no 676 0.201456629895881 990 849217 SGTC_1612 st002233 45.4 µM 0.835935597231169 0.188659833084126 no 677 0.201595567555042 994 1035021 SGTC_2884 9058502 51.95 µM 0.835012266936373 0.188924442142282 no 678 0.201855400818303 987 6471554 SGTC_1024 4507-0395 26 µM 0.832954778017709 0.189514901614283 no 679 0.202435117034811 947 4201836 SGTC_2938 9059746 27.26 µM 0.832431560743231 0.189665235741875 no 680 0.202582696875582 934 6471769 SGTC_1548 st061468 90.8 µM 0.831767653085416 0.189856099489081 no 681 0.202770052707549 1019 390799 SGTC_1089 terbinafine 2.25 µM 0.830993874936196 0.190078698366874 no 682 0.20298854476757 987 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_830 4076-0286 57.8 µM 0.829446027454764 0.190524460972133 no 683 0.203426032810589 1087 6866659 SGTC_2448 5185112 27.17 µM 0.828539390286113 0.190785860070135 no 684 0.203682548373252 920 5718189 SGTC_3242 9133940 49.47 µM 0.827593994588351 0.191058668175776 no 685 0.203950235215758 1046 17248444 SGTC_1691 st019933 84.6 µM 0.826852841294773 0.191272706270359 no 686 0.20416023775994 1005 6176082 SGTC_2415 st077333 57.7 µM 0.826652890615953 0.19133047530969 no 687 0.204216914961774 1068 2766255 SGTC_2277 7947813 106.88 µM 0.826182458322613 0.19146643310575 no 688 0.204350298726527 958 1246798 SGTC_645 0845-0943 5.41 µM 0.826056499106063 0.191502846130139 no 689 0.204386021305261 970 1885106 SGTC_660 4031-1742 102 µM 0.825386255516102 0.191696675396811 no 690 0.204576167795772 972 6738706 SGTC_244 nsc-207895 1.295 µM 0.825358406854165 0.191704731613483 no 691 0.204584070670984 886 42640 SGTC_1749 st037932 54.2 µM 0.823274779218894 0.192308083034854 no 692 0.205175876266532 944 594497 SGTC_1864 st057645 30.4 µM 0.822933752207498 0.192406943947301 no 693 0.205272833775977 1043 688666 SGTC_354 2783-3500 4.88 µM 0.820798352900115 0.193026684794578 no 694 0.205880568476162 969 6740761 SGTC_2027 5150920 200 µM 0.820713033631032 0.193051471660275 no 695 0.20590487249788 1016 786715 SGTC_1867 st057372 64 µM 0.820222466282481 0.193194028487721 no 696 0.206044648390729 1043 688837 SGTC_817 1391-0715 46 µM 0.819947721447435 0.193273896255665 no 697 0.206122955193458 959 1353946 SGTC_3172 9105863 49.47 µM 0.819247035593023 0.19347767542415 no 698 0.206322742068988 1003 2348785 SGTC_1027 k015-0025 8.67 µM 0.819186406553599 0.193495314214322 no 699 0.206340034647564 1028 3598955 SGTC_3012 9080433 71.4286 µM 0.811892094764877 0.195624598987524 no 700 0.208426775456084 1068 17688859 SGTC_2496 diffractaic acid 79.83 µM 0.811044782792702 0.195872857000987 no 701 0.208669976853471 1026 94870 An apoptosis inducer which activates caspases. SGTC_646 4092-0839 27.3 µM 0.808835151030635 0.196521166404 no 702 0.209304987127886 1066 877796 SGTC_265 mycophenolic acid 32.932 µM 0.805846938118712 0.197399978000779 no 703 0.210165554886188 1081 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_510 ag-490 170 µM 0.805844337533289 0.197400743847551 no 704 0.2101663047261 1134 5328779 SGTC_1724 st037281 8.293 µM 0.804504487760984 0.19779555530401 no 705 0.210552839292924 1022 574124 YDL195W SEC31 SGTC_1146 3579-1023 7 µM 0.804305128097384 0.197854341057471 no 706 0.210610388391222 1083 X1146 SGTC_1493 4348-0038 111 µM 0.804291946342347 0.197858228371224 no 707 0.210614193890039 1102 800424 SGTC_2586 curcumin 80 µM 0.803723486375817 0.198025911724292 no 708 0.210778343480541 1082 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_891 0929-0073 133 µM 0.802939981268289 0.198257169337021 no 709 0.211004712863087 1054 5603632 SGTC_3351 9150312 21.596 µM 0.801336619410111 0.198730921862508 no 710 0.211468398292009 1020 4904905 SGTC_876 0720-0963 56.8 µM 0.80130184487434 0.19874120440764 no 711 0.211478461546285 1063 765861 SGTC_1057 3448-5381 134 µM 0.800671402612793 0.198927676635258 no 712 0.211660951158258 1059 5497911 SGTC_1708 st033234 31.827 µM 0.79999541040101 0.199127738734091 no 713 0.211856728153896 1092 674664 SGTC_1990 st072050 59.8 µM 0.792479117465868 0.201360366448352 no 714 0.214040681663101 1087 17233948 SGTC_2889 9059656 51.95 µM 0.789346057982969 0.202295418811049 no 715 0.214954887023737 1088 3949838 SGTC_1822 st052468 42 µM 0.788688038269535 0.202492132355136 no 716 0.215147180436955 1058 2873678 SGTC_2491 paeonol 100 µM 0.788339335252737 0.202596422697493 no 717 0.215249122552035 1033 11092 Increases levels of cortical cytochrome oxidase. SGTC_2163 5671233 125 µM 0.787057315493991 0.202980125974921 no 718 0.215624157480688 1099 701023 SGTC_99 0109-0120 622.8 µM 0.786582998188833 0.203122197120394 no 719 0.215763007590069 1050 759414 SGTC_1845 st056753 3.01 µM 0.784980474203958 0.203602636279749 no 720 0.216232508442018 1066 5375839 SGTC_2514 salinomycin 42.74 µM 0.784668317352308 0.203696300182336 no 721 0.216324031651006 1122 23682228 A polyether potassium ionophore. SGTC_554 4483-2211 187 µM 0.783016148334784 0.204192467720992 no 722 0.21680881464689 1020 747107 SGTC_2662 daunorubicin 22.37 µM 0.782721305688555 0.204281088372542 no 723 0.216895394015978 1031 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.781649223078746 0.20460351648044 no 724 0.217210375215928 1021 521171 SGTC_1488 4013-0813 75.9 µM 0.780939276364335 0.204817199016891 no 725 0.217419105105849 1026 2910057 SGTC_612 0302-0167 22.4 µM 0.780502466070134 0.20494873780921 no 726 0.217547588274922 1114 235821 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.779562034948815 0.205232104778197 no 727 0.217824354917695 1053 803109 SGTC_1268 0828-0275 2.46 µM 0.779482416821894 0.20525610567888 no 728 0.217847795664124 1098 745337 SGTC_1294 1000-1494 117 µM 0.775967018324396 0.206317484630649 no 729 0.218884229984924 1068 712797 YDL207W GLE1 SGTC_2873 9040596 71.43 µM 0.775128809970588 0.206571038264109 no 730 0.219131774611058 1098 6463863 SGTC_2082 5219693 150 µM 0.77503813426867 0.206598478247144 no 731 0.219158563138047 1099 2834649 SGTC_2858 9025781 8.96 µM 0.773287276341584 0.207128740284315 no 732 0.219676192081043 1143 4894980 YPL153C RAD53 SGTC_1017 4239-0030 168 µM 0.772676100968119 0.207314029280676 no 733 0.219857046982428 1078 1149593 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.771422691993836 0.207694329602049 no 734 0.220228214541654 1097 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2469 5655019 90.81 µM 0.770322448725776 0.208028496910866 no 735 0.220554321615096 1129 2788239 SGTC_480 am 92016 50 µM 0.770231824088588 0.208056035683402 no 736 0.220581194670935 1031 2129 K+ channel blocker. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.768287721610967 0.208647322407169 no 737 0.221158133821064 1072 442882 SGTC_1603 st002045 67.8 µM 0.767837407005263 0.208784423963897 no 738 0.22129189391803 1090 5887985 SGTC_1982 st072467 71.9 µM 0.767135031653992 0.20899837319151 no 739 0.22150061772066 1059 3163533 SGTC_1346 1488-2224 62.4 µM 0.766664671435218 0.209141720891996 no 740 0.221640456837436 1097 3722427 SGTC_2995 9067767 71.4286 µM 0.761844046143321 0.210614195794599 no 741 0.223076544262693 1055 11673567 SGTC_1353 1498-1206 8.11 µM 0.761384564761202 0.210754862631173 no 742 0.223213702011045 1130 6756808 SGTC_2899 9053889 58.44 µM 0.756917479642046 0.212125297410582 no 743 0.224549651243264 1082 6470052 SGTC_2616 abietic acid 100 µM 0.756235243522612 0.212335054902275 no 744 0.224754082829352 1123 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.755133454295058 0.212674062276585 no 745 0.225084455966848 1141 16486 A toxic proline analog. SGTC_2440 5628896 157.78 µM 0.754486339064883 0.212873319133634 no 746 0.225278622623862 1094 5522048 SGTC_2401 5128683 200 µM 0.754076402195331 0.212999601434418 no 747 0.225401673074846 1084 708373 SGTC_1363 1636-0063 10.4 µM 0.752105861946424 0.213607242107139 no 748 0.225993699512638 1151 6072185 SGTC_124 0136-0217 7.121 µM 0.752083803226229 0.213614049900001 no 749 0.226000331776118 1240 3976905 SGTC_935 2996-0153 430 µM 0.751710921265181 0.213729148376529 no 750 0.226112460614611 1118 23738523 SGTC_2872 9044037 25.97 µM 0.750484646025763 0.214107920688136 no 751 0.226481433844049 1119 6465195 SGTC_2970 9090938 41.86 µM 0.749849421260307 0.214304282617731 no 752 0.226672699832293 1141 17217104 SGTC_189 3970-0742 2.116 µM 0.749806491083335 0.214317557056333 no 753 0.226685629383586 1126 2891807 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.746927646494932 0.215208815321557 no 754 0.227553618337001 1132 165506 SGTC_2718 lomofungin 53.02 µM 0.7463145106324 0.215398912863466 no 755 0.227738723939996 1116 5351222 A RNA synthesis inhibitor. SGTC_2248 tofa 1.1 µM 0.746023499621593 0.215489172424196 no 756 0.227826609760471 1060 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2930 9013230 14.89 µM 0.74545344841196 0.215666042257018 no 757 0.227998821493069 1115 2995857 SGTC_3042 9091578 49.47 µM 0.745279602048103 0.215719998325275 no 758 0.22805135482072 1086 25236497 SGTC_3124 9127567 49.47 µM 0.745246219043293 0.215730360183489 no 759 0.22806144335941 1085 17592030 SGTC_2913 7966556 36.57 µM 0.743420420500344 0.216297514936506 no 760 0.228613592442286 1068 2976516 SGTC_2989 9073649 71.4286 µM 0.743355290873129 0.216317762332525 no 761 0.228633302484513 1140 21367202 SGTC_2934 9036370 36.88 µM 0.743048321381114 0.216413207295946 no 762 0.228726212864346 1136 6462800 SGTC_2071 5230951 39.92 µM 0.742412564635477 0.216610958434946 no 763 0.228918704599497 1183 1799272 SGTC_1246 0422-0085 105 µM 0.74153782200269 0.216883216539843 no 764 0.229183704001091 1135 264295 SGTC_2348 9022543 33.42 µM 0.741021853310922 0.217043901241352 no 765 0.229340095058958 1115 3162678 YDL140C RPO21 SGTC_693 4161-2696 114 µM 0.740902903072139 0.217080954879462 no 766 0.229376157578557 1106 805759 SGTC_1320 1313-0481 95.3 µM 0.74028509779551 0.217273463323134 no 767 0.229563510673433 1164 6813365 YLR208W SEC13 SGTC_2273 7815444 169.05 µM 0.738316833447163 0.217887432549328 no 768 0.230160969771686 1109 2824616 SGTC_2942 9052777 62.25 µM 0.738217359989957 0.217918488273499 no 769 0.230191187632293 1190 6469503 SGTC_2740 felodipine 17.08 µM 0.736635236840925 0.218412771919688 no 770 0.230672100274032 1086 3333 L-type calcium channel blocker SGTC_1068 loratadine 26.9 µM 0.73531051521507 0.218827134952178 no 771 0.231075202833195 1106 3957 A H1 histamine antagonist. SGTC_867 0518-0118 155 µM 0.734075728635576 0.219213773949108 no 772 0.231451292605062 1178 6848158 SGTC_1219 1469-0211 33.1 µM 0.733144010163221 0.219505775386409 no 773 0.231735300043817 1116 6822282 SGTC_2812 7970281 58.44 µM 0.732764945812829 0.219624638419567 no 774 0.23185090239688 1147 2233435 SGTC_2363 9053361 176 µM 0.728926215821395 0.220830427882302 no 775 0.233023398772005 1165 6469797 YMR079W SEC14 SGTC_801 0866-0028 10.1 µM 0.728304027425875 0.221026220807798 no 776 0.233213748755299 1186 6849771 SGTC_785 1270-0111 65.3 µM 0.727557193044821 0.221261369014542 no 777 0.233442346393026 1163 6741994 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.727097943155893 0.221406039416062 no 778 0.233582979335227 1189 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_632 0781-2353 4.65 µM 0.725490343878631 0.221912882412212 no 779 0.234075633303387 1184 6811515 YHR007C ERG11 SGTC_2823 7987624 58.44 µM 0.723893497801054 0.22241699046079 no 780 0.234565561081003 1154 2239440 SGTC_1265 0819-1001 68.8 µM 0.722998434264625 0.222699838322993 no 781 0.234840423072935 1157 3106768 SGTC_157 1348-1695 65.819 µM 0.721173592695318 0.223277138745198 no 782 0.235401358472089 1170 5380510 SGTC_2820 7989630 71.43 µM 0.720877122756486 0.22337100929018 no 783 0.235492559713445 1052 2984098 SGTC_1459 k035-0031 35.7 µM 0.720615451735677 0.223453880193755 no 784 0.235573072171359 1063 3877128 YMR208W ERG12 SGTC_2159 5658611 73.75 µM 0.717885303242314 0.224319557597486 no 785 0.236414005216994 1187 793844 SGTC_1777 st045864 34.765 µM 0.717829035689445 0.224337418953063 no 786 0.23643135395996 1181 4691462 SGTC_2034 5197015 53.07 µM 0.713171178538584 0.225818788113496 no 787 0.237869919303085 1155 780676 SGTC_815 1582-0027 36.9 µM 0.712560293187699 0.226013481562799 no 788 0.238058944813231 1190 3128206 SGTC_2865 9030313 51.95 µM 0.712446141225703 0.226049873113831 no 789 0.238094275843066 1124 42562754 SGTC_1124 fisetin 1.16336 µM 0.711373581963648 0.226391965836722 no 790 0.238426382616157 1125 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1225 1216-0074 20.6 µM 0.708220309031851 0.227399393600899 no 791 0.239404228062947 1167 4241466 SGTC_378 3970-0959 8.33 µM 0.707824698829531 0.227525963725842 no 792 0.23952706317694 1159 6615653 SGTC_963 1269-2853 151 µM 0.707197611299219 0.22772667314781 no 793 0.239721841396167 1170 3668223 SGTC_578 3460-0051 92 µM 0.707160427883907 0.227738577425291 no 794 0.239733393565274 1236 2876744 SGTC_485 niflumic acid 177 µM 0.705098892667904 0.228399126102037 no 795 0.240374347804147 1157 4488 A COX2 inhibitor. SGTC_228 caffeine 993.056 µM 0.704288819858368 0.228658980655512 no 796 0.240626463695835 1178 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3074 9116018 49.47 µM 0.703908442310722 0.228781055139019 no 797 0.240744896805823 1226 17027303 SGTC_1665 st014639 11.4 µM 0.703405387300879 0.22894255664729 no 798 0.240901575075055 1260 981133 YIL048W NEO1 SGTC_3340 9146634 11.102 µM 0.70302536875824 0.229064600756115 no 799 0.241019969966833 1181 4907387 SGTC_2719 novobiocin 32.65 µM 0.701816508304446 0.229453072565519 no 800 0.241396801139627 1181 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_993 3909-8757 62.7 µM 0.701788917165028 0.229461943388458 no 801 0.241405405702494 1131 4288324 YLR208W SEC13 SGTC_2417 cerulenin 830 nM 0.698051204046911 0.230665430039204 no 802 0.242572586285901 1228 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1556 plumbagin 1.48 µM 0.697810449151411 0.230743070151108 no 803 0.242647871754121 1128 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_79 0052-0007 94.094 µM 0.697484406719229 0.230848237576092 no 804 0.242749847299222 1222 2801472 SGTC_200 k038-0079 37.545 µM 0.697323236040262 0.230900234268665 no 805 0.242800264849914 1152 3436683 SGTC_237 nikkomycin 200 µM 0.695026982111953 0.231641758866627 no 806 0.2435191961541 1219 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_343 4130-2827 29.8 µM 0.694853911127565 0.231697702059521 no 807 0.243573429295076 1220 1118244 SGTC_1121 fusaric acid 630.51 nM 0.694574582495479 0.23178800768592 no 808 0.243660972855612 1180 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1950 st077106 7.18 µM 0.693649865894023 0.232087104051109 no 809 0.243950906728428 1172 13831864 SGTC_293 4049-0273 38.5 µM 0.693176910823271 0.232240162726453 no 810 0.24409926806989 1123 1380311 SGTC_2300 7976697 71.57 µM 0.692534766077727 0.232448064778011 no 811 0.244300780403814 1123 2236109 SGTC_2782 7736369 71.43 µM 0.689017489239384 0.233588659543753 no 812 0.245406130852431 1251 2950836 YOL077C BRX1 SGTC_3348 9149464 3.537 µM 0.688409779445788 0.233786043747113 no 813 0.245597383569307 1219 1951442 SGTC_2781 5567276 71.43 µM 0.686783071733183 0.234314853205614 no 814 0.246109719451287 1204 2853274 SGTC_113 0099-0221 2.5 µM 0.686281726392262 0.234477963698214 no 815 0.246267734972012 1231 89219 SGTC_2000 st075254 36.4 µM 0.685655473757127 0.234681800440587 no 816 0.246465195530036 1190 17234175 SGTC_385 1494-0393 12.4 µM 0.684437557026484 0.235078496246097 no 817 0.246849453510121 1225 3090647 SGTC_662 k832-1615 104 µM 0.683605400405982 0.235349756406557 no 818 0.247112186804722 1191 5878478 SGTC_721 1187-1332 279 µM 0.67881989821902 0.236913047364783 no 819 0.248625992167147 1162 25730 SGTC_3333 9141820 12.094 µM 0.676992907502137 0.237511376899881 no 820 0.249205227198416 1212 1939433 SGTC_1123 mangostin 811.285 nM 0.67697502028789 0.23751723896244 no 821 0.249210901763895 1195 5281650 An antioxidant. SGTC_505 gw-5074 63.9 µM 0.674844293898342 0.238216096167467 no 822 0.249887347789931 1230 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3254 9136651 49.47 µM 0.673544138969747 0.238643086953298 no 823 0.25030058889818 1225 16454030 SGTC_165 k038-0023 64.381 µM 0.673374641995266 0.238698783199056 no 824 0.250354488482607 1228 46368543 SGTC_83 0170-0301 39.027 µM 0.671918915055293 0.239177423856095 no 825 0.250817658985952 1189 3089716 SGTC_2305 7443522 69.23 µM 0.671762730648987 0.239228808172132 no 826 0.250867379311858 1209 5415886 SGTC_1464 k208-0027 110 µM 0.666429382931053 0.240987082222112 no 827 0.252568343357967 1272 X1464 SGTC_585 0kpi-0023 191 µM 0.666080599117927 0.241102312025155 no 828 0.252679792224665 1203 64601 SGTC_3228 9131799 49.47 µM 0.665264502344189 0.241372047824623 no 829 0.25294066541335 1226 17015818 SGTC_2170 morpholine 200 µM 0.664607588176833 0.241589289730207 no 830 0.253150757270752 1266 121171 Reacts with secondary amines. SGTC_1148 3909-7663 27.7 µM 0.663953743730277 0.241805621854856 no 831 0.253359958483474 1300 4084526 SGTC_3143 9086658 49.47 µM 0.661989072012458 0.242456288618034 no 832 0.253989112621038 1301 25236626 SGTC_44 0929-0055 61.211 µM 0.661178233764384 0.242725101063343 no 833 0.254249009146608 1211 1379590 SGTC_2076 5212012 200 µM 0.660986720849119 0.242788615760353 no 834 0.254310414787001 1157 604802 SGTC_3131 9127911 49.47 µM 0.660822780721923 0.24284299316803 no 835 0.254362985816838 1294 45595681 SGTC_2760 etidronate 98.04 µM 0.660034999068951 0.243104384879484 no 836 0.254615684866648 1247 3305 A chelator and antioxidant. SGTC_502 l-744,832 89.3 µM 0.659819352221814 0.24317596459554 no 837 0.254684881459822 1219 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_370 0180-0345 38.7 µM 0.65970074185233 0.243215339824227 no 838 0.254722945260681 1209 3989527 SGTC_3066 9117245 49.47 µM 0.659034243367559 0.243436662223009 no 839 0.254936889748227 1300 17176980 SGTC_1104 tacrolimus 29.8 µM 0.658798627362685 0.243514928634542 no 840 0.255012544436609 1300 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2816 7982706 58.44 µM 0.657883959180191 0.243818889879094 no 841 0.255306349405254 1256 2981853 SGTC_1547 harmine 94.2 µM 0.657419852033108 0.243973199591107 no 842 0.255455495136981 1282 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3263 9137018 49.47 µM 0.657041941800326 0.244098888835007 no 843 0.255576974199804 1204 43844957 SGTC_1514 1189-1591 158 µM 0.655964389168257 0.244457463956347 no 844 0.25592351858401 1303 767698 YMR146C TIF34 SGTC_1788 fluconazole 20 µM 0.655770895902889 0.244521882381624 no 845 0.255985772596517 1237 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_764 1951-2361 146 µM 0.653634781228969 0.245233652156163 no 846 0.256673565196988 1233 5438930 SGTC_2627 acetyl isogambogic acid 100 µM 0.653425135370389 0.245303567740461 no 847 0.256741119413428 1220 6857789 A caspase activator and apoptosis inducer. SGTC_2976 9009005 19.48 µM 0.653090974678286 0.245415030390715 no 848 0.256848815194697 1286 2993148 SGTC_855 0428-0020 25 µM 0.650512876721337 0.246275895089 no 849 0.257680493415675 1255 6812414 SGTC_2112 5488546 200 µM 0.649472654995897 0.246623698208815 no 850 0.258016457851927 1248 600757 SGTC_1136 pergolide 1.05886 µM 0.645740600308347 0.247873690701501 no 851 0.25922368110988 1269 47811 A dopamine receptor agonist. SGTC_156 3474-0145 5.642 µM 0.641879813880094 0.249170350016815 no 852 0.260475610924366 1223 2265471 SGTC_1607 st000305 50.6 µM 0.641307370390197 0.249362913908733 no 853 0.260661500777896 1306 5457690 SGTC_1876 myriocin 605 nM 0.640291473105719 0.249704845605169 no 854 0.260991561623165 1334 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2810 7959871 45.46 µM 0.639641147984999 0.249923863313443 no 855 0.261202962334992 1284 2974535 SGTC_2153 5569715 200 µM 0.639490961710428 0.249974457815339 no 856 0.261251795781196 1309 2054701 SGTC_2404 5161160 200 µM 0.638729465081844 0.250231073153904 no 857 0.261499470499391 1248 2831543 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.638172444462259 0.250418870929001 no 858 0.261680716260515 1325 364106 SGTC_1192 1488-0095 21.4 µM 0.637879637718017 0.250517619761495 no 859 0.261776016818488 1283 915875 SGTC_642 0335-0876 158 µM 0.637794663376229 0.250546281150316 no 860 0.261803676967152 1301 6812350 SGTC_2178 5812956 200 µM 0.636820760716843 0.250874897308175 no 861 0.262120800770042 1272 5403383 SGTC_724 3910-0327 137 µM 0.636293485031934 0.251052906862819 no 862 0.262292575259301 1275 2885483 SGTC_2126 5251174 33.877 µM 0.633563742015158 0.251975542227099 no 863 0.263182784787575 1345 790722 SGTC_2628 lathosterol 100 µM 0.633457686217773 0.25201142447062 no 864 0.263217402272535 1332 6710616 SGTC_2821 7996764 71.43 µM 0.630741748551382 0.252931235365018 no 865 0.26410469841274 1351 2987135 SGTC_2895 9054447 58.44 µM 0.629672048686317 0.25329399668908 no 866 0.264454586886985 1310 2697450 SGTC_107 0358-0022 2.6945 µM 0.628675217256345 0.253632292606256 no 867 0.264780853014357 1322 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.628571884662672 0.253667374286791 no 868 0.264814685807143 1168 6708630 An antioxidant. SGTC_3000 9075062 71.4286 µM 0.626060402644475 0.254520811930349 no 869 0.265637661642623 1285 17057871 SGTC_1032 k061-1018 98.7 µM 0.624667863075867 0.254994664336211 no 870 0.266094534735024 1433 4005393 SGTC_410 α-linolenic acid 100 µM 0.623139939132379 0.255515115810475 no 871 0.266596283016075 1333 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1981 st071826 47 µM 0.62224885684697 0.255818898100973 no 872 0.266889122336708 1272 11838600 SGTC_2549 cedrol 20.94 µM 0.621232253442565 0.256165702362106 no 873 0.267223410416391 1313 6708665 A sedative which affects the nervous system. SGTC_1296 1068-0102 11.9 µM 0.619546522083397 0.256741312900398 no 874 0.267778192107719 1293 767053 SGTC_1275 0867-0008 21.1 µM 0.617851946677072 0.257320621242576 no 875 0.268336468693114 1314 3422836 SGTC_27 0485-0001 32.618 µM 0.617802632511322 0.257337489973181 no 876 0.268352723969624 1255 2054479 SGTC_1937 st074714 47.2 µM 0.617764567332772 0.257350511193614 no 877 0.268365271615821 1269 17250970 SGTC_908 3448-7491 47.7 µM 0.616901733829036 0.257645758470413 no 878 0.268649771567397 1317 1203031 SGTC_1240 0356-0016 42.1 µM 0.61653931416022 0.257769824885532 no 879 0.268769316488258 1322 4305613 SGTC_3081 9117243 49.47 µM 0.616026982900031 0.257945263129222 no 880 0.268938355649062 1399 45595589 SGTC_1898 st060199 18.6 µM 0.615386664014492 0.258164615394699 no 881 0.269149698208377 1316 688866 SGTC_131 0141-0277 33.849 µM 0.614816829010593 0.258359903487106 no 882 0.269337847025698 1330 1547771 SGTC_2049 5262831 67.185 µM 0.613313331190596 0.258875534236947 no 883 0.269834590129796 1348 763417 SGTC_1288 0973-0013 65.5 µM 0.611353894690224 0.259548329246177 no 884 0.270482659245767 1364 4315430 SGTC_2523 spermine 47.74 µM 0.609655309945964 0.260132287543974 no 885 0.271045082189966 1307 1103 A DNA binding polyamine. SGTC_65 0798-0905 34.986 µM 0.60788452068079 0.260741789374997 no 886 0.271632033352743 1522 3602145 SGTC_2894 9048625 32.47 µM 0.607835240219314 0.260758762106824 no 887 0.271648377049984 1414 4092861 SGTC_2642 cholecalciferol 100 µM 0.607312725780909 0.260938756775745 no 888 0.271821697293864 1336 9821465 A vitamin D precursor, similar to steriods. SGTC_1715 st032160 10.2275 µM 0.606577923301587 0.261191988043805 no 889 0.272065527441483 1297 5289825 SGTC_2228 7354201 200 µM 0.606374422682026 0.261262141758464 no 890 0.272133074454251 1341 753451 SGTC_2693 st077581 40.7 µM 0.604402378463968 0.261942474835258 no 891 0.272788077420487 1339 25238761 SGTC_738 1315-0003 72.4 µM 0.602882647113073 0.262467384116774 no 892 0.27329338035482 1355 6251474 SGTC_703 3875-0075 71.8 µM 0.601812145470726 0.262837454199611 no 893 0.273649594786492 1392 2850814 SGTC_994 3910-0338 138 µM 0.598087566604654 0.264127108977458 no 894 0.274890752980735 1426 3479481 SGTC_720 r052-1644 49.9 µM 0.597457645136939 0.264345540821372 no 895 0.275100938500715 1320 1422863 YOR257W CDC31 SGTC_1812 st052057 4.327 µM 0.596327047270158 0.26473781795258 no 896 0.275478382817827 1311 3645418 SGTC_2367 9070478 135.38 µM 0.594895516801609 0.265234932279556 no 897 0.275956657119473 1361 572802 SGTC_990 3985-0011 41.3 µM 0.594351711988456 0.265423898480855 no 898 0.276138449127505 1353 5399565 YGL099W LSG1 SGTC_1091 telmisartan 47.6 µM 0.593626388823458 0.265676046599749 no 899 0.276381013531105 1398 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1654 st012436 41.8 µM 0.591978071908985 0.26624951144391 no 900 0.276932636147026 1332 4323132 SGTC_2916 7875993 68.79 µM 0.591421790511642 0.266443188248019 no 901 0.277118921812363 1396 1299250 SGTC_643 k048-0106 28.4 µM 0.590085459898338 0.266908740684589 no 902 0.277566678189755 1388 6763920 SGTC_870 0573-2213 57.6 µM 0.588605676121488 0.267424748534404 no 903 0.27806291267491 1338 3916321 SGTC_3248 9135562 49.47 µM 0.588412878730246 0.267492014958369 no 904 0.278127597700576 1387 17650701 SGTC_3257 9139206 32.98 µM 0.586821848533813 0.268047446091557 no 905 0.278661680735193 1329 4910041 SGTC_1713 st033146 12.748 µM 0.585834931100811 0.26839227205043 no 906 0.278993223674388 1424 674619 SGTC_2876 9059903 25.97 µM 0.585574942362907 0.268483148437369 no 907 0.279080595654957 1349 6916095 SGTC_3295 9122362 53.5725 µM 0.583313367741572 0.269274310561725 no 908 0.279841182595992 1359 4730473 SGTC_802 4112-3352 742 µM 0.582281903920949 0.269635533338185 no 909 0.280188406265401 1460 704594 SGTC_1401 3807-4679 7.6 µM 0.581707854566711 0.269836672823746 no 910 0.280381739985155 1370 3291456 SGTC_3175 9106517 49.47 µM 0.580782604629367 0.270161026501595 no 911 0.280693490220121 1327 41468073 SGTC_2240 6690706 185.951 µM 0.578750657632438 0.270874025271117 no 912 0.281378714639042 1289 805876 SGTC_1563 conessine 56.1 µM 0.578412259537491 0.270992858415542 no 913 0.281492909490156 1426 441082 An anti-amoebic, histamine inhibitor. SGTC_2601 securinine 100 µM 0.577469188723556 0.271324167876378 no 914 0.281811273392637 1331 442872 A GABA receptor antagonist. SGTC_783 0848-0141 92.7 µM 0.576055962597282 0.271821024835306 no 915 0.282288677959297 1365 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_146 3448-8650 53.125 µM 0.5753279928226 0.27207713838489 no 916 0.282534746558221 1417 2891488 YIL048W NEO1 SGTC_929 2805-0021 398 µM 0.574604452144017 0.272331812526856 no 917 0.282779420174243 1425 3098024 SGTC_333 3486-0131 40.1 µM 0.574134227546638 0.272497387141332 no 918 0.282938486592307 1455 6744690 SGTC_1370 2001-0092 44.6 µM 0.573430005948598 0.272745449796786 no 919 0.283176789258101 1528 790957 SGTC_537 1334-0398 209 µM 0.572700395568677 0.273002573791704 no 920 0.283423784792044 1389 5846986 SGTC_2227 7312221 64.1025 µM 0.571048112890058 0.273585303116373 no 921 0.283983514700654 1398 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2287 7945887 168.79 µM 0.570517868896144 0.273772440672464 no 922 0.284163253038391 1407 1245853 SGTC_1165 k072-0275 30.3 µM 0.568076017703795 0.274635052695397 no 923 0.284991675720746 1375 6153523 YGL055W OLE1 SGTC_3014 9081533 49.47 µM 0.566421172993523 0.275220406726638 no 924 0.28555375244337 1441 21367265 SGTC_2524 avocatin b 10.57 µM 0.563910048261247 0.276109816859073 no 925 0.286407675623324 1365 6710748 SGTC_487 nimodipine 119 µM 0.56214640071963 0.276735321940853 no 926 0.287008138247106 1316 4497 L-type voltage-gated calcium channels inhibitor SGTC_859 0439-0102 54.6 µM 0.56153483533495 0.276952385130033 no 927 0.28721649481705 1422 610143 SGTC_614 0462-0418 107 µM 0.561526064558412 0.276955498752079 no 928 0.287219483487404 1303 5188303 SGTC_2653 dihydrofissinolide 100 µM 0.559337206823477 0.277733077716499 no 929 0.287965803608748 1409 6857746 SGTC_1336 1486-0901 104 µM 0.558599307389017 0.27799545228247 no 930 0.288217606409033 1436 5006114 SGTC_1100 amiodarone 5.07 µM 0.556710277902532 0.278667684262301 no 931 0.288862696773816 1431 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3015 9080845 49.47 µM 0.555445346271853 0.279118266140936 no 932 0.289295041612278 1489 5296973 SGTC_2545 solidagenone 89.61 µM 0.554701037138667 0.279383562272038 no 933 0.289549583338654 1312 6708572 An anti ulcer agent SGTC_754 3474-0146 171 µM 0.554335916031175 0.279513748150008 no 934 0.289674487307449 1326 24762078 SGTC_29 0299-0004 12.984 µM 0.5519908497087 0.28035059547806 no 935 0.290477311223025 1322 16871 A napthoquinone isolated from Swertia calycina. SGTC_983 1491-0821 12.2 µM 0.549706205622635 0.281167045873738 no 936 0.291260449904034 1448 46495113 SGTC_1718 roemerine 11.9335 µM 0.549600318530201 0.28120491397489 no 937 0.29129677015534 1355 235224 An aporphine alkaloid with mutagenic activity. SGTC_1365 1672-3266 55.4 µM 0.549217067717129 0.281341995463623 no 938 0.291428246394665 1434 6415873 SGTC_2463 5473429 200 µM 0.548837886879017 0.281477652934945 no 939 0.291558353645129 1419 5399405 SGTC_1779 st039427 55 µM 0.548077821983212 0.281749672221461 no 940 0.291819234096007 1558 1124498 SGTC_2347 9049783 174.81 µM 0.5467875330932 0.282211743075301 no 941 0.292262354518877 1472 6467988 YPL169C MEX67 SGTC_1495 4469-0029 237 µM 0.545406864563985 0.282706583754177 no 942 0.292736860127514 1399 793680 SGTC_3187 9109394 49.47 µM 0.543943174732399 0.283231634672846 no 943 0.293240288666673 1335 17098090 SGTC_2684 capsaicin 100 µM 0.543892837931903 0.283249699672447 no 944 0.293257608884812 1407 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1720 st037298 9.481 µM 0.540258675757915 0.284555395159198 no 945 0.294509326388209 1427 597396 SGTC_488 nitrendipine 139 µM 0.540220865163163 0.284568994987377 no 946 0.294522362473579 1458 4507 Dihydropyridine L-type calcium channel blocker. SGTC_104 0074-0074 590.992 µM 0.539995858125755 0.284649932612769 no 947 0.294599944410095 1339 3943124 SGTC_1411 3909-8223 150 µM 0.535993618540734 0.286091417478414 no 948 0.295981480410561 1484 X1411 SGTC_2925 9010536 32.5 µM 0.533723267071932 0.286910667761151 no 949 0.296766504549151 1513 2994177 SGTC_2359 9039622 200 µM 0.532148899537638 0.287479425957461 no 950 0.297311435920983 1425 6463596 SGTC_154 3389-1638 511.116 µM 0.531969739736436 0.287544183249794 no 951 0.297373476958267 1320 5238686 SGTC_1295 1013-0063 9.78 µM 0.531726786632564 0.287632009640707 no 952 0.297457618349607 1490 6826038 SGTC_1469 k284-2957 126 µM 0.531139541122024 0.28784434844285 no 953 0.297661042626369 1474 23884841 SGTC_1575 cyproterone acetate 48 µM 0.530297131725498 0.288149079733838 no 954 0.297952967528433 1370 9880 An androgen receptor antagonist and liver toxin. SGTC_1630 st005209 31.3 µM 0.528996907395205 0.288619718517705 no 955 0.298403797616555 1453 3367314 SGTC_412 gemfibrozil 100 µM 0.52826011211082 0.288886575004364 no 956 0.298659406246299 1416 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3220 9131269 49.47 µM 0.527368957082159 0.289209493406956 no 957 0.298968698228763 1459 17722206 SGTC_2190 6049624 200 µM 0.526758778103052 0.289430695320771 no 958 0.299180556097179 1441 2265554 SGTC_1051 3253-3903 78 µM 0.526103112866985 0.289668475444482 no 959 0.299408282980667 1409 5509239 SGTC_2063 5246145 200 µM 0.525398988131855 0.289923931693853 no 960 0.299652928398809 1478 711240 SGTC_2104 5389443 200 µM 0.525020896084812 0.290061146960052 no 961 0.299784332379166 1527 2244536 SGTC_1482 3346-2049 8.48 µM 0.524722077746076 0.290169614141178 no 962 0.299888203639529 1471 3826804 SGTC_430 0958-0115 16.4 µM 0.52447121027028 0.290260690453486 no 963 0.299975419435439 1457 6833180 SGTC_3111 9122088 49.47 µM 0.523066084356942 0.290771062483031 no 964 0.30046413311955 1405 16876704 SGTC_1241 0364-0022 50.8 µM 0.522381452993521 0.291019887294748 no 965 0.300702383448029 1514 4563895 SGTC_263 alizarin 107.927 µM 0.522140322032204 0.291107548454557 no 966 0.300786316832446 1475 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_629 3448-6466 76.7 µM 0.521863981757457 0.291208024830148 no 967 0.300882518945924 1444 573744 SGTC_1903 st060211 78.3 µM 0.520286830980189 0.291781781099942 no 968 0.30143183655345 1518 688960 SGTC_1432 4049-0298 68.4 µM 0.519307884997108 0.292138179437256 no 969 0.301773027832746 1522 741646 SGTC_2814 7977482 42.97 µM 0.519289332889525 0.29214493553492 no 970 0.301779495460208 1560 6456762 SGTC_2221 6807166 181.081 µM 0.518546034095824 0.292415681514428 no 971 0.302038675194984 1469 674925 SGTC_2955 9076254 12.21 µM 0.517731723170439 0.292712427436721 no 972 0.302322730729494 1458 16459619 SGTC_2334 9017922 200 µM 0.517537242749399 0.292783319418637 no 973 0.302390588929347 1587 3163164 SGTC_3195 9113082 49.47 µM 0.51745087276308 0.2928148055528 no 974 0.302420727375921 1464 17018038 SGTC_2606 farnesol 9.78 µM 0.517393530912014 0.292835710363413 no 975 0.30244073731975 1534 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2681 menadione 3.18 µM 0.515228637474572 0.293625460283798 no 976 0.303196629822837 1450 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3219 9131112 49.47 µM 0.514746402674814 0.293801513014563 no 977 0.303365121527589 1423 17612988 YMR079W SEC14 SGTC_413 propylparaben 100 µM 0.514072312572017 0.294047689475641 no 978 0.303600717120295 1416 7175 A pharmaceutical preservative. SGTC_2975 9084847 53.72 µM 0.513729173617584 0.29417303979943 no 979 0.303720676112937 1466 27211724 SGTC_3290 9121031 71.43 µM 0.512827268818459 0.294502627670664 no 980 0.304036076577017 1429 17014854 SGTC_3297 9117502 71.43 µM 0.511459013887658 0.295002961468216 no 981 0.304514840462828 1457 7453720 SGTC_1451 4152-0210 104 µM 0.511389488548539 0.295028395454583 no 982 0.304539176916127 1558 659563 SGTC_789 1309-1135 70.6 µM 0.510044743970174 0.295520532890835 no 983 0.305010057626985 1430 3092424 SGTC_3120 9124077 49.47 µM 0.50894801953387 0.295922181429758 no 984 0.305394329912958 1476 18774327 YGL155W CDC43 SGTC_3122 9126309 49.47 µM 0.507948969514106 0.296288277122241 no 985 0.305744565609803 1489 17591206 SGTC_989 1501-0895 10.3 µM 0.507919107179872 0.296299223185916 no 986 0.305755037148062 1494 2830112 SGTC_2433 5607874 27.82 µM 0.506607167712456 0.296780298617996 no 987 0.306215239044746 1425 2252428 SGTC_342 k048-0088 23.3 µM 0.505532751085164 0.297174542851554 no 988 0.306592350639174 1433 6820570 SGTC_201 4262-0159 12.803 µM 0.505228101902312 0.297286373748257 no 989 0.306699317349822 1532 1341029 SGTC_1063 disulfiram 1.84 µM 0.504606359927195 0.297514663001376 no 990 0.306917670984396 1461 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_715 0868-0130 184 µM 0.502931809890247 0.298129916713409 no 991 0.30750610777169 1622 2876258 SGTC_1798 st045719 60.953 µM 0.50236662187891 0.298337705651497 no 992 0.30770482677416 1420 3980186 SGTC_1627 st003713 25.6 µM 0.501766264043557 0.298558496802457 no 993 0.30791597322419 1475 16195070 YER133W GLC7 SGTC_2485 5633444 17.78 µM 0.500737720793391 0.298936932590229 no 994 0.308277860732765 1429 5724239 SGTC_1457 k015-0032 57.3 µM 0.499503848155292 0.299391203236986 no 995 0.308712238248628 1474 4302660 SGTC_1644 st010134 20.9 µM 0.499437365091925 0.299415688963559 no 996 0.308735650823185 1458 3818134 SGTC_1222 0366-0074 1.18 µM 0.498951509547587 0.299594657223787 no 997 0.308906772568165 1574 286520 SGTC_2968 9090663 33.37 µM 0.497543674007772 0.300113516731577 no 998 0.309402856335958 1499 25236811 SGTC_2064 5220758 200 µM 0.496246900534424 0.300591803448826 no 999 0.30986011236175 1515 788518 SGTC_286 k060-0067 22.9 µM 0.4951191834366 0.301008016943797 no 1000 0.310257996633526 1473 5985051 SGTC_2288 7946289 167.31 µM 0.494962275360017 0.301065948556919 no 1001 0.310313374995455 1619 1246052 SGTC_1915 st067105 30.6 µM 0.493358786445056 0.301658256263219 no 1002 0.310879548839928 1438 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2355 9061122 103.12 µM 0.493119194357111 0.301746803411331 no 1003 0.310964184607171 1567 5302957 SGTC_755 1995-0008 37.3 µM 0.492837672333558 0.301850861727009 no 1004 0.311063644878108 1495 689533 SGTC_1444 4112-3581 28 µM 0.492349746540379 0.302031250761901 no 1005 0.311236059213919 1501 2877249 SGTC_1892 st058411 7.36 µM 0.492346795067411 0.302032342086113 no 1006 0.311237102277792 1567 3934738 SGTC_472 calcifediol 10 µM 0.492059793157655 0.302138471160764 no 1007 0.311338537287278 1506 5283731 A vitamin D metabolite. SGTC_559 1550-0661 158 µM 0.489531608401715 0.303074078926989 no 1008 0.312232691172165 1558 5830875 SGTC_2276 7947513 42.08 µM 0.489199978753024 0.303196901529477 no 1009 0.312350062289005 1343 2105100 SGTC_3260 9137109 49.47 µM 0.489099457962885 0.303234134878961 no 1010 0.312385642596201 1542 17478346 SGTC_1561 5-methoxyflavone 52.9 µM 0.488978350419184 0.303278996368807 no 1011 0.312428512107597 1481 94525 SGTC_127 0180-0333 59.125 µM 0.488296547487805 0.303531609849467 no 1012 0.312669903302522 1468 771601 SGTC_3250 9135583 49.47 µM 0.486180985625548 0.304316040012674 no 1013 0.313419425721404 1567 7699353 SGTC_1053 3366-3204 134 µM 0.485426811964639 0.304595898512584 no 1014 0.313686808536419 1464 3632071 YPR165W RHO1 SGTC_1617 st002906 78 µM 0.484875038246789 0.304800723000587 no 1015 0.313882495014687 1485 5150859 SGTC_555 4296-0685 37 µM 0.484632957856278 0.304890605227765 no 1016 0.313968365322456 1533 2908540 YHR072W ERG7 SGTC_1686 st019653 115.5 µM 0.484570503102193 0.304913796015708 no 1017 0.313990520792221 1585 97252 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.483315223639591 0.305380074229693 no 1018 0.314435966145305 1499 688662 SGTC_2234 tolnaftate 200 µM 0.482234810889307 0.305781650584761 no 1019 0.314819575217988 1517 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_560 2332-1943 155 µM 0.481607520834128 0.306014913960069 no 1020 0.315042391256312 1521 21177716 SGTC_309 k408-0051 1.48 µM 0.481352664102762 0.306109707183327 no 1021 0.315132936664651 1499 3640463 SGTC_2041 5107442 45.335 µM 0.481352600947379 0.306109730675398 no 1022 0.31513295910385 1581 793005 SGTC_831 k061-1017 217 µM 0.479500363983689 0.306799054662133 no 1023 0.31579135466765 1595 1240153 SGTC_1818 st052136 56.3 µM 0.477116569673942 0.307687207878706 no 1024 0.316639558126131 1453 674169 SGTC_185 k048-0037 25.491 µM 0.476363405668546 0.307968056249471 no 1025 0.316907750342141 1560 6827589 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.476194647306205 0.308031000224218 no 1026 0.316967856271414 1473 61125 An anti-inflammatory. SGTC_1712 st032288 53.4 µM 0.475542365135941 0.308274343372809 no 1027 0.317200222170444 1480 2883011 SGTC_2994 9053520 71.4286 µM 0.475212277844247 0.308397519259183 no 1028 0.317317838373158 1613 4647384 SGTC_1423 4048-0112 5.59 µM 0.474436547890644 0.308687076753734 no 1029 0.317594317906437 1592 X1423 SGTC_3319 9138450 16.7555 µM 0.473027088298182 0.309213491566904 no 1030 0.318096926702969 1499 2029690 SGTC_445 e6 berbamine 66 µM 0.473013872860965 0.309218429216863 no 1031 0.318101640873181 1529 6610268 A calcium/calmodulin antagonist. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.472540053895641 0.309395483742694 no 1032 0.318270679584546 1604 94937 An inhibitor of serotonin biosynthesis. SGTC_2207 7258803 200 µM 0.470583217858835 0.310127173862807 no 1033 0.31896919715677 1560 3666799 SGTC_1830 st055982 50.3 µM 0.470304890390536 0.310231305832479 no 1034 0.319068602018599 1582 455313 An antimicrobial agent. SGTC_31 0508-1974 57.237 µM 0.469571503104318 0.31050576434007 no 1035 0.319330594135473 1559 6810525 SGTC_567 1080-0542 68.4 µM 0.469514024093005 0.310527279405582 no 1036 0.319351131504864 1554 5950415 SGTC_1926 methyl fluorone black 53.6 µM 0.468088320085822 0.311061144350083 no 1037 0.319860715726778 1426 72721 Reacts with homocysteine. SGTC_2465 5809242 33.21 µM 0.466130374163812 0.311794959232436 no 1038 0.320561091475241 1595 2731748 SGTC_663 1486-0733 13.9 µM 0.465755217874904 0.31193564881693 no 1039 0.320695361492576 1523 722445 YPR165W RHO1 SGTC_251 melphalan 456.522 µM 0.464923423745896 0.312247682720302 no 1040 0.320993147779595 1619 460612 A DNA alkylator. SGTC_508 roscovitine 141 µM 0.464778815914213 0.312301943725138 no 1041 0.321044929834228 1595 160355 A CDKinase inhibitor. SGTC_1560 lithocholic acid 53.1 µM 0.464352410826155 0.312461966837368 no 1042 0.321197639828685 1543 9903 A bile acid which acts as a detergent. SGTC_2483 5729050 27.16 µM 0.464131076397199 0.31254504410878 no 1043 0.321276919050779 1668 2865180 SGTC_922 1866-0035 480 µM 0.463023674837094 0.3129608472562 no 1044 0.321673698684694 1582 3156169 SGTC_2449 5812982 45.77 µM 0.462936294734095 0.312993666560902 no 1045 0.321705015457789 1528 776185 SGTC_3245 9134821 49.47 µM 0.462767603066542 0.313057030065039 no 1046 0.321765477641006 1459 17014901 SGTC_968 1309-0633 340 µM 0.462617770759327 0.313113314297827 no 1047 0.321819184242221 1568 3761976 SGTC_1829 berberine 14.4 µM 0.461105577115391 0.313681610666724 no 1048 0.322361430315875 1624 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1759 st043059 70 µM 0.460206759392106 0.314019604416946 no 1049 0.322683909841101 1489 669426 SGTC_1909 st060837 51.5 µM 0.459070576412454 0.314447080942911 no 1050 0.323091742618797 1499 678937 SGTC_2921 7974240 10.71 µM 0.458499935819756 0.314661872218033 no 1051 0.323296654302907 1598 2979074 YDR527W RBA50 SGTC_1692 fluoroquinolonic acid 71 µM 0.458165153340945 0.314787914810154 no 1052 0.323416896510642 1577 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.457728880451468 0.314952200012097 no 1053 0.32357361821774 1548 17037758 SGTC_2592 piperlongumine 83.33 µM 0.456751964698335 0.31532020529072 no 1054 0.323924667792277 1471 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_345 1362-0200 395 µM 0.456527081830499 0.315404944891262 no 1055 0.324005500470505 1497 1419823 SGTC_247 mechlorethamine 29.705 µM 0.456334461788239 0.315477535043983 no 1056 0.324074743085476 1557 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_307 1501-1223 22.3 µM 0.454897902687768 0.316019136420595 no 1057 0.324591345918933 1544 2830329 SGTC_2575 plumbagin 510 nM 0.454885606782808 0.31602377384291 no 1058 0.324595769123681 1479 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_492 tmb-8 126 µM 0.452944324383245 0.316756294616146 no 1059 0.32529441640383 1545 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_982 1491-0518 27.5 µM 0.452093455580167 0.317077587090353 no 1060 0.325600829052524 1563 3091256 SGTC_2644 guaiazulene 100 µM 0.45169404372163 0.317228454673298 no 1061 0.325744704876268 1603 3515 A coloring agent. SGTC_2018 5133068 143 µM 0.451507429752977 0.317298953726515 no 1062 0.325811935711328 1525 785362 SGTC_3087 9117406 49.47 µM 0.451400891104778 0.317339204886026 no 1063 0.325850320599699 1535 42546093 SGTC_326 k292-0812 17.5 µM 0.450316350043438 0.317749076099859 no 1064 0.326241175687333 1630 3579357 SGTC_1808 st050063 61.5 µM 0.450021833705748 0.317860418707005 no 1065 0.326347348686978 1612 4011993 SGTC_981 1488-1094 54.9 µM 0.448749066475135 0.31834178068486 no 1066 0.326806342395178 1520 3449522 SGTC_3052 9092717 49.47 µM 0.447532521813559 0.318802166108713 no 1067 0.327245305869032 1545 25237534 SGTC_3171 9103192 49.47 µM 0.447482845322478 0.318820971477374 no 1068 0.327263235625551 1611 13018434 SGTC_1571 st070080 73.4 µM 0.445227683188365 0.319675168880073 no 1069 0.328077611429702 1659 4315245 SGTC_2831 7999036 19.48 µM 0.444908927018096 0.319795982847567 no 1070 0.328192785543833 1731 2988270 SGTC_1679 SEC14.276 6.7 µM 0.444891978157779 0.319802407287103 no 1071 0.328198910023828 1687 1005053 YMR079W SEC14 SGTC_535 2293-4129 48.2 µM 0.443806566786487 0.320213943313641 no 1072 0.328591220135246 1670 396118 YIL048W NEO1 SGTC_1251 0490-5699 265 µM 0.443795630993207 0.320218090769523 no 1073 0.328595173721011 1681 3883818 SGTC_2026 5148700 152 µM 0.443268983197345 0.320417851235157 no 1074 0.328785593883059 1539 79838 SGTC_2475 5812728 15.03 µM 0.441953202438471 0.320917161598276 no 1075 0.329261535227396 1522 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1345 1488-0192 31.4 µM 0.439766265869851 0.321747773388909 no 1076 0.330053201294195 1654 658348 SGTC_2898 9056270 58.44 µM 0.439393834539928 0.321889314035823 no 1077 0.330188096580908 1555 19154699 SGTC_2370 9071495 200 µM 0.438161393088 0.322357881377274 no 1078 0.330634646377126 1533 21791103 SGTC_753 1322-0200 289 µM 0.437241055925401 0.322707972637316 no 1079 0.33096826895287 1571 5403907 SGTC_1784 st039334 36.3 µM 0.437155049651504 0.322740696993808 no 1080 0.330999453124413 1675 3496984 SGTC_2649 anisomycin 9.56 µM 0.436718931558685 0.322906655827086 no 1081 0.331157598950181 1561 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3191 9110352 49.47 µM 0.435876671146311 0.323227266429627 no 1082 0.331463105983879 1604 17122424 SGTC_213 1246-0773 967 nM 0.435628718905296 0.323321675714673 no 1083 0.331553065289668 1594 6251622 SGTC_2844 9010103 25.97 µM 0.434315497265937 0.323821882228231 no 1084 0.332029675841851 1566 2480525 SGTC_40 0327-0103 19.753 µM 0.43413303705404 0.323891406587557 no 1085 0.332095918076213 1518 409036 SGTC_1324 1418-0026 34.4 µM 0.431621684138522 0.324848952069352 no 1086 0.33300819788023 1606 1372513 SGTC_1562 morin hydrate 59.1 µM 0.43095933165945 0.325101691578676 no 1087 0.333248970634612 1610 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2763 lisinopril 49.32 µM 0.430703997071467 0.325199143287361 no 1088 0.333341806059245 1576 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2074 5212007 75.395 µM 0.428462409955293 0.326055186280929 no 1089 0.334157247702196 1690 758611 SGTC_2310 7668677 200 µM 0.427155545538747 0.326554690370593 no 1090 0.334633018927599 1624 2197143 SGTC_1669 st015249 58.4 µM 0.425621539469396 0.327141408487995 no 1091 0.3351918212204 1662 722793 SGTC_2391 6285546 200 µM 0.423051625184134 0.328125292362642 no 1092 0.336128797811309 1557 846083 SGTC_1332 1480-0653 17.5 µM 0.422052269119024 0.328508215528598 no 1093 0.336493433045412 1672 5749438 SGTC_2060 5238662 140 µM 0.420761744409684 0.32900297230531 no 1094 0.336964534579987 1576 790130 SGTC_1800 st050079 29.0735 µM 0.418622447426604 0.329823788326439 no 1095 0.337746040811386 1595 3645560 SGTC_1262 0737-0114 49.6 µM 0.417946592754013 0.330083274257824 no 1096 0.337993082858353 1660 765919 SGTC_3134 9127454 49.47 µM 0.417047497899731 0.330428597179493 no 1097 0.338321833023994 1640 24262820 SGTC_628 1636-0253 16 µM 0.414447238933571 0.331428112588349 no 1098 0.33927329965669 1676 4456143 SGTC_259 usnic acid 108.925 µM 0.41365394954024 0.331733285253612 no 1099 0.339563778454272 1670 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2497 7-hydroxyflavone 100 µM 0.413455440973805 0.331809667537229 no 1100 0.339636481260034 1678 5281894 SGTC_2979 9012552 45.46 µM 0.412835583610758 0.332048221736507 no 1101 0.339863539429617 1639 17100905 SGTC_1466 k213-0079 57.5 µM 0.412165891652438 0.332306031468649 no 1102 0.340108917671625 1599 3657981 SGTC_1620 st003704 16.5 µM 0.411899531318028 0.332408593647034 no 1103 0.340206532168837 1628 2834414 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.410837244406839 0.332817752512832 no 1104 0.340595940613473 1599 75037 A free radical scavenger. SGTC_266 formosanin C 406 nM 0.410684678794756 0.332876532264055 no 1105 0.340651881410126 1626 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_583 1488-1091 88.9 µM 0.409881593888772 0.333186008670901 no 1106 0.340946404016725 1701 4303273 SGTC_383 2324-0395 7.37 µM 0.409549538477088 0.333314002596054 no 1107 0.341068210051183 1676 3146421 SGTC_1282 0886-0010 32.4 µM 0.408273443558257 0.333806066091377 no 1108 0.341536466894313 1741 2836211 YNL267W PIK1 SGTC_3203 9113543 49.47 µM 0.407331364558324 0.334169516237591 no 1109 0.341882314824631 1675 17018012 SGTC_11 0438-0307 1.3 µM 0.406417427264248 0.334522258094338 no 1110 0.342217958468622 1712 4011476 SGTC_2900 5328528 85.29 µM 0.405308424241963 0.33495048344882 no 1111 0.34262540747182 1564 795359 SGTC_1524 corynanthine 62.1 µM 0.404012704706538 0.33545107858069 no 1112 0.343101688353479 1651 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_285 1486-1325 46 µM 0.401828560882971 0.336295573469026 no 1113 0.343905100603961 1674 22310230 SGTC_865 0488-0499 301 µM 0.401113627115938 0.336572180993243 no 1114 0.344168234189796 1647 9634651 SGTC_1453 4237-0541 195 µM 0.400835283161902 0.336679896063811 no 1115 0.344270699960752 1750 739892 SGTC_1040 k898-0338 155 µM 0.400187371870315 0.336930680218263 no 1116 0.344509257510907 1804 20969351 SGTC_691 1548-0686 185 µM 0.398700318638472 0.337506541366561 no 1117 0.345057016528092 1585 46495133 SGTC_1087 pterostilbene 9.05 µM 0.396972513183672 0.338176111955357 no 1118 0.345693865041141 1736 5281727 Similar to reservatol, lowers cholesterol. SGTC_1277 0873-0036 22 µM 0.395655689296936 0.338686760301716 no 1119 0.346179524143458 1728 5965735 SGTC_321 4534-3890 65.3 µM 0.394955873776205 0.338958261071265 no 1120 0.346437726828547 1749 699746 SGTC_3300 9124615 50.48 µM 0.393095693049896 0.339680344163087 no 1121 0.347124402517769 1702 24824903 SGTC_770 0389-1121 67.2 µM 0.392364012547286 0.339964528663533 no 1122 0.347394636186949 1761 6753108 SGTC_1426 4048-4480 71.7 µM 0.390403325314045 0.340726507122002 no 1123 0.348119164661237 1712 14224343 SGTC_2292 7671323 168.05 µM 0.389840214555123 0.340945468228597 no 1124 0.348327352407027 1615 937504 SGTC_1670 st016595 4.04 µM 0.389645261613056 0.341021286609272 no 1125 0.34839943913658 1652 597879 SGTC_1217 1183-1422 255 µM 0.388362082844955 0.341520482687703 no 1126 0.348874049970391 1730 2849664 SGTC_547 1120-0019 610 nM 0.387327741281985 0.341923075372258 no 1127 0.349256795334816 1638 3676939 SGTC_761 k216-0224 480 µM 0.386382139033722 0.342291285760411 no 1128 0.3496068380138 1825 1340404 SGTC_821 1114-0266 29.2 µM 0.384509278388708 0.34302100599225 no 1129 0.350300510163997 1618 3123235 SGTC_1878 temozolomide 1 mM 0.383517885336783 0.343407518498981 no 1130 0.350667905799601 1788 5394 DNA alkylating agent. SGTC_2043 5101342 149 µM 0.383399511110519 0.343453679787249 no 1131 0.350711782884286 1664 678451 SGTC_2226 7298446 200 µM 0.382994095959072 0.343611793426632 no 1132 0.350862070842201 1734 3283010 SGTC_2161 5662504 8.5105 µM 0.382492865653708 0.343807313213623 no 1133 0.351047909870288 1632 2859334 SGTC_2487 5918373 44.05 µM 0.382188095682196 0.343926218234635 no 1134 0.351160925558432 1725 2876279 SGTC_1138 3761-0006 1.03 µM 0.376482789034452 0.346154963296689 no 1135 0.353279004142267 1683 12061087 SGTC_2338 7999974 200 µM 0.375551058123226 0.346519447784387 no 1136 0.353625340738434 1841 315925 SGTC_573 3702-0553 84.7 µM 0.375413404726084 0.346573308575627 no 1137 0.353676518593688 1665 1222756 SGTC_3032 9089427 49.47 µM 0.375015588515181 0.346728982869768 no 1138 0.353824436675443 1628 17173707 SGTC_69 0096-0274 206.684 µM 0.373297755323603 0.347401505943037 no 1139 0.354463423449809 1741 6741392 SGTC_484 loperamide 105 µM 0.373230320824989 0.347427916029407 no 1140 0.354488515603151 1673 3955 An opioid-receptor agonist. SGTC_2244 6635614 200 µM 0.37247336033411 0.3477244232738 no 1141 0.354770221401784 1658 836499 SGTC_2511 berberine 10.47 µM 0.370309106598761 0.348572691557179 no 1142 0.355576094642397 1658 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_136 0097-0015 404.482 µM 0.370178083017342 0.348624069952694 no 1143 0.355624902856685 1732 4861337 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.369996440184095 0.348695302314105 no 1144 0.355692571403759 1668 88881 An O-methylated flavonoid and antioxidant. SGTC_2118 5526350 200 µM 0.36940850948435 0.348925899541806 no 1145 0.355911628098802 1712 743594 SGTC_2279 7948423 32.93 µM 0.36940466843239 0.348927406256572 no 1146 0.355913059390226 1838 1247112 SGTC_2293 7624732 200 µM 0.369058764363702 0.349063102486786 no 1147 0.356041961968359 1596 894453 SGTC_3020 9089140 49.47 µM 0.36905823522309 0.349063310080477 no 1148 0.356042159167401 1665 17217859 SGTC_2040 5100729 123 µM 0.368908946401204 0.349121881226602 no 1149 0.356097797358317 1712 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1681 tripelennamine 100 µM 0.368429636791018 0.349309955182084 no 1150 0.356276451129157 1619 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1367 1812-0510 76.9 µM 0.368352342784052 0.349340287666045 no 1151 0.356305263992433 1703 1142582 YDR527W RBA50 SGTC_1313 1220-0047 237 µM 0.367813501259641 0.34955177194986 no 1152 0.356506150567871 1731 3528706 SGTC_2811 7967822 32.47 µM 0.367642329809134 0.349618963023002 no 1153 0.356569973671112 1749 2232244 SGTC_3051 9093778 49.47 µM 0.366536679252607 0.350053084839746 no 1154 0.356982323979107 1704 17217378 SGTC_3160 9100216 49.47 µM 0.365708970551422 0.350378204124603 no 1155 0.357291125814864 1694 17191039 SGTC_814 3342-0569 96 µM 0.3648356351495 0.350721364212153 no 1156 0.357617051432424 1695 4346283 SGTC_3004 9076122 71.4286 µM 0.364767410475081 0.350748176899252 no 1157 0.357642517011127 1764 44782551 SGTC_1060 3448-7350 82 µM 0.362579790067849 0.351608317658061 no 1158 0.358459404775423 1792 570178 SGTC_1653 st012112 65 µM 0.361480199260029 0.352040948293123 no 1159 0.358870252218635 1738 720429 SGTC_3347 9188721 44.724 µM 0.361241958067181 0.352134708832689 no 1160 0.358959289406709 1724 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1998 st075797 76.8 µM 0.361053950112926 0.352208706276284 no 1161 0.359029558482647 1795 24208315 SGTC_3061 glucosamine 200 µM 0.360582303723402 0.352394364677268 no 1162 0.359205860076238 1796 91431 and experimental redox chemotherapeutic SGTC_2242 6630449 61.2675 µM 0.360400826658723 0.352465810496506 no 1163 0.35927370426007 1723 691249 YDR170C SEC7 SGTC_93 0109-0045 59.227 µM 0.360230509864224 0.352532867357331 no 1164 0.359337380275976 1729 88733 SGTC_499 genistein 192 µM 0.359535923016122 0.352806386439333 no 1165 0.359597104577639 1745 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2936 9038235 15.59 µM 0.359365085069028 0.352873671820774 no 1166 0.359660995325671 1659 4749415 SGTC_1203 3992-3522 103 µM 0.359287984990338 0.352904039580206 no 1167 0.359689830846474 1902 5322312 SGTC_471 1-acyl-paf 4 µM 0.358749312352217 0.353116235162703 no 1168 0.359891317329461 1629 16759367 SGTC_2086 5274770 176.623 µM 0.358502711429559 0.353213392204008 no 1169 0.359983569562465 1675 689278 SGTC_1970 st070122 35.8 µM 0.357647778923118 0.353550296758699 no 1170 0.360303458871161 1741 102928 SGTC_1660 st012960 28.1 µM 0.356383594026387 0.354048686278644 no 1171 0.360776656987574 1694 24207266 SGTC_1680 diphenhydramine 100 µM 0.355971657939592 0.35421114114879 no 1172 0.360930895227291 1684 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2734 clemastine 41.6 µM 0.355651373391109 0.3543374698212 no 1173 0.361050832677713 1735 26987 Clemastine is a selective histamine H1 antagonist. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.354921537630768 0.354625396151255 no 1174 0.361324186426002 1679 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_771 0250-0039 27.3 µM 0.35474906053693 0.354693451954566 no 1175 0.361388796597976 1699 3005115 SGTC_139 0099-0334 718.624 µM 0.353796508303507 0.355069392352797 no 1176 0.361745695221802 1761 97690 SGTC_2730 imipramine 71.33 µM 0.352730350505448 0.355490336430212 no 1177 0.362145301805371 1775 3696 A tricyclic antidepressant. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.35156294812541 0.355951456485844 no 1178 0.362583028248967 1692 4620898 SGTC_1655 st012546 55.1 µM 0.348662452282343 0.357098053992196 no 1179 0.363671368043199 1717 720985 YLR208W SEC13 SGTC_838 0109-0203 71.4 µM 0.34851574123235 0.357156084871892 no 1180 0.363726447085863 1695 759422 SGTC_962 1254-0300 21.5 µM 0.347014636190815 0.357750029710401 no 1181 0.364290161565334 1713 7340576 SGTC_3031 9088762 49.47 µM 0.345304246971084 0.358427202362145 no 1182 0.364932827095113 1661 205253 SGTC_2841 9004761 38.96 µM 0.345268022515838 0.358441549074338 no 1183 0.364946442265754 1582 2991039 SGTC_1487 3970-0795 2.82 µM 0.343112645999558 0.359295545930603 no 1184 0.365756858923643 1749 3765103 SGTC_1792 st045773 43.6 µM 0.342187265987341 0.359662413326613 no 1185 0.366104983855974 1712 2919270 SGTC_544 k015-0020 52.4 µM 0.341970105567693 0.359748525443431 no 1186 0.366186694877315 1713 3008304 SGTC_957 1187-1561 14.1 µM 0.341047145179311 0.360114592677889 no 1187 0.366534045143079 1722 1538454 SGTC_2430 5571206 200 µM 0.340560874539156 0.360307510385251 no 1188 0.366717094003341 1869 1731771 SGTC_2546 rhodinyl acetate 100 µM 0.339976698852343 0.360539316906909 no 1189 0.366937037746732 1842 6708682 SGTC_103 0844-0104 51.839 µM 0.335486656748612 0.362322714171196 no 1190 0.368629004240802 1801 5375804 SGTC_334 1502-1024 68.5 µM 0.335125551150331 0.362466272007077 no 1191 0.368765189587581 1738 3296216 SGTC_435 c-PAF 6.7 µM 0.334378482916673 0.362763330990887 no 1192 0.369046987027376 1818 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_331 k048-0133 24.5 µM 0.333712657774129 0.36302815467441 no 1193 0.369298198553097 1700 6813582 SGTC_1744 st037937 38.9 µM 0.333264075257665 0.363206609742931 no 1194 0.369467477319582 1775 1016152 SGTC_2761 levamisole 97.89 µM 0.332951909173316 0.363330813162295 no 1195 0.36958529240985 1844 26879 An alkaline phosphatase inhibitor. SGTC_727 3032-0951 202 µM 0.332364478770967 0.363564576626586 no 1196 0.369807028633111 1760 3652836 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.3321352355717 0.36365581600281 no 1197 0.369893572371011 1705 115019 SGTC_757 1066-0008 322 µM 0.331986953282594 0.363714836849964 no 1198 0.369949555310742 1795 6842497 SGTC_223 busulfan 5 mM 0.331830065921248 0.363777286297923 no 1199 0.370008790035733 1792 2478 A DNA alkylator. SGTC_910 3454-3003 490 µM 0.331398340507761 0.363949154469376 no 1200 0.370171809114111 1821 820824 SGTC_2731 amoxapine 43.43 µM 0.331319719612888 0.363980456082412 no 1201 0.370201498795734 1830 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2832 7992762 51.95 µM 0.330234506110276 0.364412608585827 no 1202 0.370611387921069 1542 2985177 SGTC_2764 methyldopa 94.69 µM 0.330130141463725 0.364454177654154 no 1203 0.370650814582221 1848 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1010 4112-3296 15.2 µM 0.329952579227945 0.36452490542699 no 1204 0.370717896799284 1889 704384 SGTC_2713 st079149 53.4 µM 0.329643366759696 0.364648084005896 no 1205 0.370834725264748 1758 3103253 SGTC_3197 9113331 49.47 µM 0.328896747413749 0.364945566568996 no 1206 0.371116866432077 1846 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1175 0741-0056 27.6 µM 0.327690550431707 0.365426334699927 no 1207 0.371572824455656 1828 765927 SGTC_2120 5538279 151.968 µM 0.325432535989356 0.366326906225581 no 1208 0.372426867159489 1765 2058197 SGTC_1667 st014849 34.6 µM 0.325307108732411 0.366376952443869 no 1209 0.372474325613226 1770 5348460 SGTC_1797 st048695 56.8 µM 0.325283071394954 0.36638654374338 no 1210 0.372483420945708 1828 592262 YIL048W NEO1 SGTC_2202 7226349 200 µM 0.325249739774358 0.366399843755351 no 1211 0.372496033199485 1720 844334 SGTC_33 0986-0033 35.816 µM 0.324652911263444 0.366638017928372 no 1212 0.372721888513836 1774 2848082 SGTC_913 3487-1245 167 µM 0.324241998042 0.366802029426584 no 1213 0.372877414127671 1645 4016153 SGTC_2499 avocadenofuran 51.48 µM 0.323643883616495 0.367040803684314 no 1214 0.373103830129126 1655 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_305 1682-2595 20.8 µM 0.322176023831573 0.367627008297667 no 1215 0.373659673561158 1783 226033 SGTC_885 0865-0106 16.8 µM 0.321820368447185 0.367769089350807 no 1216 0.373794391369692 1677 2793380 SGTC_2351 9026858 72.31 µM 0.321153162371541 0.368035680843929 no 1217 0.374047162267744 1672 1409300 SGTC_1928 4'-methoxychalcone 40.3 µM 0.320902456194764 0.368135870431457 no 1218 0.374142156262857 1930 641818 SGTC_1384 3089-0840 101 µM 0.318922934237854 0.368927260328412 no 1219 0.374892476360689 1848 1069836 SGTC_3021 9087658 49.47 µM 0.318636479290511 0.36904182782268 no 1220 0.375001093855107 1842 25237042 SGTC_2624 nerol 100 µM 0.316847475181302 0.369757601888518 no 1221 0.3756796693533 1830 637566 A natural product oil. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.31662245888347 0.369847662111027 no 1222 0.375765046100238 1831 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3235 9132602 49.47 µM 0.315223538137193 0.370407724259148 no 1223 0.376295967531034 1778 4912240 SGTC_3212 9128307 49.47 µM 0.314261351279299 0.37079309826479 no 1224 0.376661274751541 1584 27243542 SGTC_1257 0669-0121 16 µM 0.313927531355357 0.370926829761212 no 1225 0.376788039817791 1863 4307855 SGTC_2612 dictamnine 15.46 µM 0.312372476380772 0.371550005101391 no 1226 0.377378732621078 1763 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2051 5263410 176 µM 0.311018818704252 0.372092746426241 no 1227 0.377893157690592 1830 227584 SGTC_1838 st055369 84.5 µM 0.310853728555306 0.372158955793845 no 1228 0.377955911072066 1732 676036 SGTC_3096 9117468 49.47 µM 0.310317458707241 0.372374052768078 no 1229 0.378159777952254 1830 41316311 SGTC_2399 5884133 200 µM 0.309392995559268 0.372744946906183 no 1230 0.378511298965876 1707 722445 SGTC_1492 4158-0558 28.5 µM 0.307396611286935 0.373546297439318 no 1231 0.379270753607346 1872 3967268 SGTC_160 3453-0671 289.699 µM 0.307235799520395 0.373610871289412 no 1232 0.379331949150944 1720 5322268 SGTC_587 k089-0003 57 µM 0.305838547803089 0.374172085901706 no 1233 0.379863788464157 1879 9659696 SGTC_1390 3413-2614 145 µM 0.304479589437203 0.374718175690709 no 1234 0.380381270155915 1762 3421432 SGTC_248 streptozotocin 5.23457 mM 0.303626400636747 0.375061153323053 no 1235 0.38070626788256 1877 5300 DNA alkylating agent. SGTC_1290 0986-0249 10.2 µM 0.303069043171034 0.375285261618 no 1236 0.380918622656636 1853 53329 SGTC_1352 1496-0991 99 µM 0.303034773179449 0.375299042640111 no 1237 0.380931680791849 1749 3000039 SGTC_844 0330-0132 15.3 µM 0.302702855499381 0.375432525224341 no 1238 0.381058160728223 1848 2828079 SGTC_1689 st020265 53.493 µM 0.302011582778938 0.375710572344047 no 1239 0.381321616610863 1884 5758320 YPR016C TIF6 SGTC_197 4544-0043 41.561 µM 0.301150058205056 0.376057189354389 no 1240 0.381650035377997 1780 896523 SGTC_2385 9074692 200 µM 0.299983911013008 0.376526524385138 no 1241 0.382094713969457 1751 17046906 SGTC_980 1473-0395 201 µM 0.298543730636908 0.377106400492605 no 1242 0.382644102345997 1741 768876 SGTC_974 1326-0144 138 µM 0.298308825134379 0.377201009485194 no 1243 0.382733734638227 1753 5411856 SGTC_752 1896-0090 130 µM 0.298248631164074 0.377225253998816 no 1244 0.382756703708797 1759 772567 SGTC_710 3448-4187 58 µM 0.297167052079285 0.377660967374273 no 1245 0.383169487443368 1773 3946412 SGTC_1301 naphtanilide LB 4.81 µM 0.295802251863082 0.3782109983582 no 1246 0.383690551590219 1880 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3070 9117005 49.47 µM 0.295397855326612 0.378374022519908 no 1247 0.383844985724056 1852 8779016 SGTC_2587 piperic acid 92.2 µM 0.295355980115055 0.378390904889371 no 1248 0.383860978414126 1750 5370536 SGTC_2819 7996655 46.38 µM 0.295095766577949 0.378495817527258 no 1249 0.383960361794137 1871 6456960 SGTC_2296 7971656 126.45 µM 0.29468419978915 0.378661770903445 no 1250 0.384117567114177 1757 666570 SGTC_2387 9077560 195.08 µM 0.29382097628585 0.379009915507104 no 1251 0.384447352727692 1764 5303272 SGTC_2007 4011539 71.82 µM 0.293399754956414 0.379179832930662 no 1252 0.384608306364811 1730 45595301 SGTC_1583 clindamycin 39.6 µM 0.292458196990561 0.379559734497559 no 1253 0.384968158659346 1708 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_845 0330-0138 4.51 µM 0.292139242317545 0.379688453314991 no 1254 0.38509008184175 1899 9039800 SGTC_1407 3909-7909 12.3 µM 0.291813364817908 0.379819979710655 no 1255 0.385214663068217 1773 4411780 SGTC_1348 1493-0373 93.8 µM 0.290353087147697 0.380409528348411 no 1256 0.385773064739788 1824 3010129 SGTC_1803 st050068 52.4 µM 0.289511840338774 0.380749285833862 no 1257 0.386094860194767 1822 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1841 st054148 70 µM 0.289295680317013 0.380836602052494 no 1258 0.386177558835986 1764 675442 SGTC_2061 5245884 80.95 µM 0.288937524567487 0.380981289736796 no 1259 0.386314593676433 1777 573863 SGTC_748 act1.228 77.9 µM 0.288148648471861 0.381300038409685 no 1260 0.386616477470475 1726 4421505 YNR035C ARC35 SGTC_61 0978-8327 98.565 µM 0.286773475008535 0.381855875428 no 1261 0.387142887072509 1924 6150059 YHR072W ERG7 SGTC_811 0416-0114 265 µM 0.286098799719891 0.382128664373792 no 1262 0.387401225417448 1794 6612453 SGTC_2302 7771753 200 µM 0.286073218205766 0.382139008804484 no 1263 0.387411021757489 1725 2203047 SGTC_3255 9139072 49.47 µM 0.285876322682098 0.382218630523008 no 1264 0.387486424521476 1820 17646060 SGTC_1191 1487-1166 10.6 µM 0.284529690526323 0.382763322564838 no 1265 0.388002242049434 1875 3955771 SGTC_2045 5106652 78.05 µM 0.284269159981231 0.382868729985134 no 1266 0.388102059203962 1895 673349 SGTC_1193 1488-0126 41.5 µM 0.282486482707691 0.383590211443246 no 1267 0.388785254973099 1779 1384710 SGTC_1096 rimcazole 32.2 µM 0.280950689307925 0.384212098474936 no 1268 0.389374110633434 1802 18528119 A dopamine reuptake inhibitor. SGTC_656 4090-1979 187 µM 0.280336665412891 0.384460817990191 no 1269 0.38960961156282 1934 22330961 SGTC_592 k241-0073 46.5 µM 0.280182074525057 0.384523444829862 no 1270 0.389668909291483 1922 4230158 SGTC_1924 st058459 75.1 µM 0.280038172001711 0.384581744378533 no 1271 0.389724109502419 1841 688683 SGTC_927 2425-1185 123 µM 0.27955773033489 0.384776405676437 no 1272 0.389908420370277 1755 730375 SGTC_2850 9015429 58.44 µM 0.279183185573383 0.384928180714397 no 1273 0.390052123396793 1771 6457570 SGTC_1269 0831-0796 3.05 µM 0.278331419354847 0.385273403606489 no 1274 0.390378979727875 1899 927758 SGTC_2892 9047358 58.44 µM 0.276967405664522 0.385826430940545 no 1275 0.390902566972259 1808 6466771 SGTC_58 0957-0393 9 µM 0.276206197173019 0.386135157213427 no 1276 0.391194848830871 1802 6997992 SGTC_3023 9089636 49.47 µM 0.275868718449556 0.386272052849602 no 1277 0.391324450490561 1952 17249241 SGTC_1185 1319-0113 81.3 µM 0.275423980879544 0.386452478829367 no 1278 0.391495261097687 1873 4672763 SGTC_2555 cholic acid 100 µM 0.274397866321057 0.386868857768915 no 1279 0.391889441269337 1843 6708657 Influences liver metabolism. SGTC_2260 7964312 200 µM 0.273152372192525 0.387374431966913 no 1280 0.392368044832103 1942 231951 SGTC_2683 piperine 63.03 µM 0.272717595785757 0.387550962566449 no 1281 0.392535153882931 1838 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2767 sibutramine 71.45 µM 0.272005382397953 0.387840190064336 no 1282 0.392808940388342 1937 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_654 1124-0271 80.9 µM 0.271541681141006 0.388028531071138 no 1283 0.392987223274045 1759 5403748 SGTC_889 0919-1524 82.7 µM 0.271466136319659 0.388059217520821 no 1284 0.393016270715938 1809 3905452 SGTC_731 3966-0296 387 µM 0.270612914166784 0.388405846461234 no 1285 0.393344381129118 1823 660956 SGTC_174 3553-0389 74.3 µM 0.270039365515074 0.388638905584054 no 1286 0.393564984438645 1878 738071 SGTC_3 0833-0587 95.581 µM 0.269818936732202 0.388728486577788 no 1287 0.393649776782513 1845 5382644 SGTC_1478 0453-0656 35.7 µM 0.268949500164909 0.389081878270233 no 1288 0.393984272102051 1892 5258496 SGTC_257 daunorubicin 18.5 µM 0.268420441691991 0.389296964619615 no 1289 0.394187853234308 1960 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_215 1287-0124 461.5 µM 0.267306722165697 0.389749853091273 no 1290 0.394616505742558 1968 5560863 SGTC_2186 6124449 200 µM 0.264980709884767 0.390696196616206 no 1291 0.395512161044639 1907 3834182 YLR033W RSC58 SGTC_2857 9024691 58.44 µM 0.264513096337232 0.390886524663283 no 1292 0.395692287331513 1829 16478292 SGTC_2383 9036125 200 µM 0.264454900446802 0.39091021338218 no 1293 0.395714706140984 1858 79580 SGTC_2144 5628481 200 µM 0.263708903404472 0.391213908348666 no 1294 0.396002117200811 1838 2818399 SGTC_173 1273-0061 2.693 µM 0.262660456237015 0.3916408426836 no 1295 0.396406149085241 1761 2847414 YPL266W DIM1 SGTC_1114 scopoletin 1.73284 µM 0.262561118260422 0.391681300515839 no 1296 0.396444435962018 1945 5280460 A coumarin with genotoxic properties. SGTC_1973 st070275 50.2 µM 0.262518484032712 0.391698664712155 no 1297 0.396460868366874 1956 17118334 SGTC_294 k038-0071 157 µM 0.262147118611256 0.391849924657887 no 1298 0.396604010597178 1838 24152826 SGTC_976 1348-1067 47.6 µM 0.260725067131357 0.392429287961063 no 1299 0.397152266846078 1832 5310671 YGL099W LSG1 SGTC_2664 lyso-paf C-16 73.48 µM 0.259760091968516 0.392822568006622 no 1300 0.397524418221075 1871 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1248 0469-0687 58.6 µM 0.259432800482506 0.392955982024727 no 1301 0.397650662338643 1891 4017482 SGTC_85 0868-0259 160.055 µM 0.258124151151172 0.393489553025851 no 1302 0.398155546535571 1863 83173 SGTC_2035 5154463 94.595 µM 0.258078372216436 0.393508221938148 no 1303 0.398173211396023 1951 2769623 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.257606584288153 0.393700634018081 no 1304 0.39835527382898 1830 689007 SGTC_2837 9008476 45.46 µM 0.257552599890729 0.393722652452199 no 1305 0.398376107759065 1878 2992805 SGTC_1005 4092-0690 4.4 µM 0.257366244324403 0.393798663279253 no 1306 0.398448029261779 1812 1529343 SGTC_1055 3448-0672 86 µM 0.255896394392645 0.394398328207594 no 1307 0.399015419406475 1869 748378 SGTC_986 1493-0483 84 µM 0.255260245804266 0.394657939895374 no 1308 0.399261051160061 1979 40079 SGTC_2330 7979373 200 µM 0.25503701273602 0.394749052213282 no 1309 0.39934725609519 1726 1863007 SGTC_1152 3909-8331 15.9 µM 0.254471267998273 0.394979986044147 no 1310 0.399565749231528 1844 16001939 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.253425942877918 0.395406778916983 no 1311 0.399969541158512 1856 5106787 A p450 inhibitor. SGTC_630 4356-0227 183 µM 0.251325485017851 0.3962647478969 no 1312 0.400781236579694 1886 779312 SGTC_2275 7947463 200 µM 0.24917358329432 0.397144251316668 no 1313 0.401613256284328 1984 1225414 SGTC_1172 0370-0043 85 µM 0.24906517861044 0.397188571260611 no 1314 0.401655182132184 1905 376585 SGTC_2127 5253358 187.912 µM 0.248774901271512 0.397307254175668 no 1315 0.401767453366374 1814 20612 SGTC_3193 9111931 49.47 µM 0.248609032648623 0.397375075560508 no 1316 0.401831610395937 1862 17087244 SGTC_2676 harmalol 100 µM 0.248396033582553 0.397462172481728 no 1317 0.401914001089767 1945 5459187 A monoamine oxidase inhibitor SGTC_3016 9080866 49.47 µM 0.247136380443564 0.397977358512081 no 1318 0.402401339628804 1844 17066299 SGTC_3179 9107801 49.47 µM 0.2463812997132 0.398286264634975 no 1319 0.402693540404233 1829 4818259 SGTC_3139 9095020 49.47 µM 0.246002869485526 0.398441105737472 no 1320 0.402840005611439 1939 25236292 SGTC_1230 0170-0365 3.77 µM 0.245568943221331 0.398618673657236 no 1321 0.403007966429276 1983 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2140 5586273 200 µM 0.244585193228646 0.399021313831433 no 1322 0.403388814997163 1906 854421 SGTC_2345 9052315 157.45 µM 0.244367780424565 0.399110313484757 no 1323 0.403472996478295 1856 6469265 SGTC_1875 nocodazole 6 µM 0.243855212147364 0.39932015811922 no 1324 0.403671478826675 2012 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_254 nsc-64875 3.808 µM 0.243009986688123 0.399666255589428 no 1325 0.403998830527628 1994 56993 SGTC_1147 3809-1045 12.3 µM 0.239641318429294 0.401046416964006 no 1326 0.40530416521988 1860 325925 SGTC_926 2268-1401 59.4 µM 0.239296326440489 0.401187832077031 no 1327 0.405437906875985 1997 2931578 SGTC_1996 st072960 66.8 µM 0.238361165407717 0.40157122749441 no 1328 0.405800492477858 2008 1719405 SGTC_2427 5545055 42.75 µM 0.237830625291743 0.401788779408744 no 1329 0.40600623226527 1891 5372858 SGTC_350 k064-0020 19.8 µM 0.237828278388095 0.401789741841681 no 1330 0.406007142435988 2023 2790705 SGTC_2906 7926292 26.41 µM 0.235768104211138 0.402634820080846 no 1331 0.406806309822068 1888 2966319 SGTC_10 0279-0212 42.575 µM 0.235768103195435 0.402634820497598 no 1332 0.406806310216168 1920 39851 YBR002C RER2 SGTC_538 2922-0838 53.3 µM 0.235567289115496 0.402717218333493 no 1333 0.406884229334037 2011 777039 SGTC_1958 st076513 41.9 µM 0.235357176190536 0.402803436288415 no 1334 0.406965760500493 1861 732122 YGL099W LSG1 SGTC_3239 9133757 49.47 µM 0.234226580984167 0.403267446940991 no 1335 0.407404540131552 1955 17036923 SGTC_1412 3909-8563 178 µM 0.234213582790211 0.403272782358438 no 1336 0.407409585357124 2005 23767530 SGTC_2327 6189656 200 µM 0.233870942356704 0.403413433753274 no 1337 0.407542586160728 1977 5349088 SGTC_3216 9129716 49.47 µM 0.233821110179827 0.403433890538962 no 1338 0.407561930123747 1856 8056934 SGTC_439 amiodarone 34.4 µM 0.233146905822294 0.403710686536351 no 1339 0.407823666375476 1952 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1120 ficusin 1.78878 µM 0.231897768702273 0.404223649737329 no 1340 0.408308708806897 1969 6199 A DNA cross-linker. SGTC_109 0132-0036 33.701 µM 0.231321991463959 0.404460150497966 no 1341 0.408532331613252 2018 67274 A color developer. SGTC_577 r071-0003 38.6 µM 0.230037768449805 0.404987771341394 no 1342 0.40903121079936 1900 4568517 YMR134W ERG29 SGTC_448 monastrol 171 µM 0.229571834135791 0.40517924242415 no 1343 0.409212247721832 1973 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_598 3937-0236 20.2 µM 0.229355724865574 0.405268058092451 no 1344 0.409296222694691 1948 1379313 SGTC_495 decylubiquinone 155 µM 0.228687115655307 0.405542871137373 no 1345 0.409556054831025 1865 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_421 streptovitacin 30 mM 0.228440373416166 0.405644299378238 no 1346 0.409651952818618 1855 91467 include heat shock SGTC_3030 9087619 49.47 µM 0.22815399051849 0.405762030633539 no 1347 0.409763264185389 1872 25236973 SGTC_2421 5690543 90.72 µM 0.227989518540345 0.405829648485081 no 1348 0.409827194478088 1904 3397993 SGTC_3308 9128332 17.569 µM 0.227923448312453 0.405856812121307 no 1349 0.409852876664677 2009 17332805 YDL196W YDL196W SGTC_2887 9044784 58.44 µM 0.227916962974842 0.405859478480596 no 1350 0.409855397603884 2015 6465546 SGTC_2047 4141938 200 µM 0.226604498589328 0.40639917026026 no 1351 0.410365646959139 1895 3807862 SGTC_795 0685-0265 78 µM 0.225773605665479 0.406740929509963 no 1352 0.41068875334282 1920 302754 SGTC_246 cycloheximide 667 µM 0.224565526778404 0.407237957908766 no 1353 0.411158642777902 1900 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1471 k673-0312 37 µM 0.224557418011771 0.407241294527095 no 1354 0.41116179716217 2007 24099884 SGTC_2258 7960471 200 µM 0.223120506915203 0.407832664847683 no 1355 0.411720859207985 1864 2974708 SGTC_951 1171-0579 82.7 µM 0.223040707988849 0.407865512795532 no 1356 0.41175191200974 1910 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2836 9010338 19.48 µM 0.222919256105586 0.407915507757749 no 1357 0.411799174624239 1767 2994051 SGTC_1641 st009299 47.1 µM 0.22266970395236 0.408018239156792 no 1358 0.411896291066912 2000 4046054 SGTC_2904 7225135 42.03 µM 0.221837484395555 0.408360878862562 no 1359 0.412220199028317 2039 4446116 SGTC_59 0330-0160 1.33 µM 0.22160402616563 0.40845701039664 no 1360 0.412311073997092 1954 4293482 SGTC_3267 9137951 49.47 µM 0.220696999471638 0.408830550711184 no 1361 0.412664183967846 1913 16643986 SGTC_2271 7849410 118.62 µM 0.219235409287837 0.409432650740381 no 1362 0.413233336862416 2071 972430 SGTC_1128 3448-9350 235 µM 0.219167689496744 0.4094605530042 no 1363 0.413259711827801 1854 619386 SGTC_2704 st078022 71.1 µM 0.217838731267061 0.410008209992555 no 1364 0.413777382979603 2031 54697681 SGTC_1158 4092-0494 91.8 µM 0.217392720078745 0.410192048361369 no 1365 0.413951152042768 1989 1148199 SGTC_1223 0764-0573 147 µM 0.21709659353844 0.410314117685481 no 1366 0.414066534313242 1931 1609797 SGTC_1228 0124-0032 52.5 µM 0.21611043941627 0.410720692868602 no 1367 0.414450831254931 1993 X1228 SGTC_2457 5731572 11.68 µM 0.215940815670597 0.410790635642273 no 1368 0.414516940635605 2050 2865357 SGTC_2839 9003951 25.97 µM 0.215456929937726 0.410990177004009 no 1369 0.414705544195494 2096 2990634 SGTC_2922 7999257 32.47 µM 0.215034533470273 0.411164380690774 no 1370 0.414870197234582 1956 2988377 SGTC_2650 prasterone 100 µM 0.213574601131998 0.411766617015726 no 1371 0.415439403872658 1974 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_73 0327-0325 16.231 µM 0.212933424425857 0.412031174447346 no 1372 0.415689445622928 2066 53298 SGTC_34 0469-0683 81.75 µM 0.212931858516635 0.412031820609835 no 1373 0.415690056327434 1973 3690923 SGTC_607 4491-0986 66.8 µM 0.210398440624131 0.413077530532666 no 1374 0.416678354809276 2045 698981 YDR232W HEM1 SGTC_1093 fluphenazine 7.97 µM 0.208078619908256 0.414035616121941 no 1375 0.417583790319885 1937 6602611 An atypical antipsychotic. SGTC_2918 7977171 22.06 µM 0.206904944866996 0.414520539083749 no 1376 0.41804204731794 1927 2236483 SGTC_2854 9024559 71.43 µM 0.205423931876019 0.41513262960531 no 1377 0.418620462013309 1885 3163529 SGTC_1629 st005085 44.9 µM 0.203768034435852 0.415817242362597 no 1378 0.419267386775095 1882 24207091 SGTC_2480 5767542 37.17 µM 0.203294698957319 0.41601298481863 no 1379 0.419452349319751 1982 2867358 SGTC_2688 kanamycin b 96.69 µM 0.202790381656866 0.416221562377345 no 1380 0.419649438034179 1950 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1927 st060202 13.8 µM 0.202511535665376 0.416336898747666 no 1381 0.419758420541466 2064 688887 SGTC_132 0417-1715 25.805 µM 0.20232621983916 0.416413553125829 no 1382 0.419830851680397 2082 6769098 SGTC_2139 5578692 56.4705 µM 0.201595288331942 0.416715927945584 no 1383 0.42011656448607 2079 650991 YMR113W FOL3 SGTC_17 0960-0276 49.807 µM 0.199325916119178 0.417655044651366 no 1384 0.421003903887006 2013 6821114 SGTC_1259 0671-0132 43 µM 0.198909636506332 0.417827361569543 no 1385 0.421166715648527 1915 X1259 SGTC_2777 climbazole 1.536 µM 0.198798883864229 0.417873209744956 no 1386 0.421210034556915 2036 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1253 0550-0034 176 µM 0.198585418533279 0.417961580951838 no 1387 0.421293530380585 1952 5969915 SGTC_904 1141-0088 396 µM 0.19644786635159 0.41884672081074 no 1388 0.422129817070502 1871 1378119 SGTC_68 0986-0284 82.829 µM 0.196364525631061 0.418881239756918 no 1389 0.422162430072437 1768 423278 YIL048W NEO1 SGTC_746 1095-0025 46.6 µM 0.195599038835205 0.419198326400423 no 1390 0.422462006323515 2005 6749286 SGTC_3136 9095672 49.47 µM 0.193758012249557 0.419961147089529 no 1391 0.423182682632219 2116 17217380 SGTC_1510 1123-0200 71.5 µM 0.193714539355695 0.419979163524703 no 1392 0.423199703365551 2048 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2200 6600604 21.907 µM 0.193594811177029 0.420028783240814 no 1393 0.423246580705183 1983 2904777 SGTC_2912 7964298 10.93 µM 0.191089882087381 0.421067207399235 no 1394 0.424227587250335 1935 2975850 SGTC_368 fentichlor 4.58 µM 0.190975944740523 0.421114453506898 no 1395 0.424272219799182 1928 7329 A pesticide. SGTC_3205 9113483 49.47 µM 0.190806820766088 0.421184585806435 no 1396 0.424338472334174 2046 17018033 SGTC_1969 st069479 40.1 µM 0.190775546115603 0.421197555046969 no 1397 0.424350724083264 2065 3895485 SGTC_938 3126-1755 342 µM 0.190411689082238 0.421348448685628 no 1398 0.42449326933751 2094 1777771 SGTC_2860 9025725 38.96 µM 0.190408466500247 0.421349785160858 no 1399 0.424494531865897 1861 40546248 SGTC_1801 st050089 28.441 µM 0.189869248639946 0.421573423349377 no 1400 0.42470579506501 2000 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3322 9139058 2.11 µM 0.189634345176139 0.421670856422684 no 1401 0.424797835982159 2031 4908926 YPR165W RHO1 SGTC_402 epigallocatechin gallate 10 µM 0.18918926306967 0.421855480374038 no 1402 0.424972241267546 1929 65064 An antioxidant. SGTC_3056 9094900 49.47 µM 0.187061893672332 0.422738168380389 no 1403 0.425806052585241 1903 25236784 SGTC_3110 9122132 49.47 µM 0.186927570865105 0.422793914664202 no 1404 0.425858710884833 2050 918317 SGTC_1934 st074720 32.6 µM 0.186011036495248 0.423174333461376 no 1405 0.42621805325098 1961 17250992 SGTC_483 fpl-64176 144 µM 0.184136869050322 0.42395245222478 no 1406 0.426953041823778 2081 3423 SGTC_1745 st081495 74 µM 0.183612439249067 0.424170238763672 no 1407 0.427158751963879 1974 13842402 YBL026W LSM2 SGTC_181 1447-1644 8.07 µM 0.183327452011178 0.424288598703145 no 1408 0.427270547904747 2081 534600 SGTC_1831 st055328 12 µM 0.182494263867976 0.424634674722192 no 1409 0.427597427772571 2078 1103068 SGTC_3278 9139605 49.47 µM 0.182020294832556 0.424831570148087 no 1410 0.427783399487756 2061 7958859 SGTC_678 1218-2179 85.9 µM 0.181403641805971 0.425087767186654 no 1411 0.42802538027752 2079 6820081 YOR116C RPO31 SGTC_690 glyoxal 20.3 µM 0.181313731757597 0.425125124206786 no 1412 0.428060664139364 2013 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2600 tangeritin 87.95 µM 0.181068059441526 0.425227202828522 no 1413 0.428157077519832 1970 68077 A bioactive flavone. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.18094407865755 0.425278719643451 no 1414 0.428205735043878 1961 688803 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.18089794229033 0.425297890671454 no 1415 0.42822384201079 2072 6728940 SGTC_303 1348-1668 34.2 µM 0.180248395513195 0.425567815337648 no 1416 0.428478783220614 2014 5380509 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.17904877873229 0.426066417877374 no 1417 0.428949700304996 2113 551469 SGTC_147 4466-0538 29.23 µM 0.178615137838281 0.426246683276606 no 1418 0.429119953682442 1991 6742687 YHR072W ERG7 SGTC_2558 carylophyllene oxide 100 µM 0.17860824883904 0.426249547172018 no 1419 0.429122658504763 2124 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3149 9097855 49.47 µM 0.176245020793584 0.42723221707146 no 1420 0.430050726420649 2082 25236625 YMR079W SEC14 SGTC_1279 0874-0590 65.2 µM 0.176114430089772 0.427286532104053 no 1421 0.430102022270637 2030 3523074 SGTC_1513 0337-0559 19 µM 0.174913674811931 0.427786012388421 no 1422 0.430573732489168 1929 775073 SGTC_2286 7945697 125 µM 0.173944376985736 0.428189297379609 no 1423 0.430954588205131 1936 1245733 SGTC_712 r015-0009 80.6 µM 0.173127479071215 0.428529233298564 no 1424 0.431275612952927 2055 6813872 YLR060W FRS1 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.171935691400632 0.429025267238061 no 1425 0.431744043356237 2032 5393153 SGTC_1435 4092-0789 56.7 µM 0.171868210584726 0.429053356789036 no 1426 0.431770569470056 2106 2248285 SGTC_2250 alverine citrate 130 µM 0.17163111398264 0.429152053421402 no 1427 0.431863772492712 1937 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_635 k038-0028 24.7 µM 0.170755630134682 0.42951653099842 no 1428 0.432207959299545 2029 4035102 SGTC_1960 st011366 51.8 µM 0.17073700589928 0.429524285211852 no 1429 0.432215281771908 2079 3972846 SGTC_1082 camptothecin 424.86 nM 0.167891005220203 0.430709537392176 no 1430 0.433334513240503 1828 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3086 9117350 49.47 µM 0.167430725351103 0.430901285576543 no 1431 0.433515575526013 2098 2679265 SGTC_2888 9058547 12.99 µM 0.166989719364011 0.431085019727873 no 1432 0.433689069051431 1989 16476514 SGTC_2225 6654152 15.4 µM 0.166314848026121 0.431366216911417 no 1433 0.433954590870587 2091 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2625 euphol 100 µM 0.165146000844472 0.431853320167513 no 1434 0.434414533310883 2133 6708538 A triterpene alcohol. SGTC_1023 4482-3888 16 µM 0.161263706542722 0.433471960160086 no 1435 0.435942853531326 2120 3303168 SGTC_1732 st034308 51.822 µM 0.161010334588726 0.433577637308805 no 1436 0.436042630509538 1904 830119 SGTC_2843 9000894 45.46 µM 0.160867955215139 0.433637023417427 no 1437 0.436098700789426 2109 2242070 SGTC_827 3253-0474 693 µM 0.157959342498689 0.434850525136501 no 1438 0.437244418205783 2133 5402065 SGTC_3128 9127691 49.47 µM 0.156752871791542 0.435354057343435 no 1439 0.437719808215864 2055 41316314 SGTC_2582 agaric acid 100 µM 0.156126619287867 0.435615471262349 no 1440 0.437966608243531 2045 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3356 9151811 4.48 µM 0.155970167541061 0.43568078264652 no 1441 0.438028268128111 2026 1859254 YPR165W RHO1 SGTC_322 k048-0136 19.3 µM 0.15559198900414 0.435838661974967 no 1442 0.438177319942462 2058 6823282 SGTC_3293 9120939 62.045 µM 0.155391840054722 0.435922222896913 no 1443 0.438256208361267 2070 934087 SGTC_458 nppb 133 µM 0.153666077685788 0.436642836061487 no 1444 0.438936516561372 2148 4549 A chloride channel blocker. SGTC_1373 2887-0003 58.5 µM 0.15170844770399 0.437460522851403 no 1445 0.439708446998289 2041 776948 SGTC_418 lividomycin a 100 µM 0.150817370811178 0.437832807422835 no 1446 0.440059891540379 2145 72394 An antibiotic. SGTC_399 oxolinic acid 75 µM 0.149401900389349 0.43842429229904 no 1447 0.440618256133811 2026 4628 A DNA gyrase inhibitor. SGTC_1015 4130-4525 82 µM 0.149118998332293 0.438542525568596 no 1448 0.44072986749776 1946 1363237 SGTC_516 3992-2719 87.3 µM 0.148670926321693 0.438729799543617 no 1449 0.44090665183591 2033 5350887 YDR037W KRS1 SGTC_580 1123-0028 41 µM 0.147268719193616 0.439315947591044 no 1450 0.441459960852999 2138 1677248 YPR107C YTH1 SGTC_617 3770-0098 35 µM 0.147066452580381 0.439400509721827 no 1451 0.441539784437874 2017 5962639 SGTC_611 3453-1652 23.7 µM 0.147056471547863 0.439404682589763 no 1452 0.44154372346777 2143 1560575 SGTC_2992 9074591 71.4286 µM 0.146678110878826 0.439562872498453 no 1453 0.4416930483503 2167 17741321 SGTC_1350 1495-0454 146 µM 0.146661043871061 0.43957000832086 no 1454 0.441699784258939 2126 1069057 SGTC_649 1123-0311 367 µM 0.146143644426901 0.4397863455653 no 1455 0.441903996495464 2135 693629 YIL048W NEO1 SGTC_2314 7727897 200 µM 0.14540149666123 0.440096686906179 no 1456 0.442196941528723 2033 900724 SGTC_479 n-linoleoylglycine 10 µM 0.144594577592785 0.440434155196755 no 1457 0.44251548934749 2032 6433346 An anti-infammatory. SGTC_805 3852-0218 479 µM 0.144582230102969 0.440439319479239 no 1458 0.442520364061081 1970 6615355 SGTC_3115 9123671 49.47 µM 0.144546197626056 0.440454389959741 no 1459 0.442534589512718 2176 3286988 SGTC_2358 9037157 4 µM 0.143859378708584 0.440741666475883 no 1460 0.442805756521194 2077 2388925 SGTC_374 0880-0231 82.3 µM 0.143673548674987 0.440819399178991 no 1461 0.442879129778358 2129 6833587 SGTC_2663 amphotericin b 100 µM 0.143640358965697 0.440833282674488 no 1462 0.442892234632062 2060 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2987 9018338 71.43 µM 0.14311557912915 0.441052811530859 no 1463 0.443099450616054 2172 5055682 SGTC_1326 1431-2094 10.8 µM 0.142976592355999 0.44111095629731 no 1464 0.443154333917881 2015 616278 SGTC_2635 hydroquinidine 100 µM 0.141823821053727 0.441593264078754 no 1465 0.443609583888266 2053 442912 An experimental heart treatment. SGTC_624 k048-0052 28 µM 0.140238051555705 0.442256875288516 no 1466 0.444235954080565 2046 6835531 SGTC_2784 7567673 72.73 µM 0.139379916608736 0.442616054432034 no 1467 0.444574970834795 2145 3471247 SGTC_3313 9133968 57.047 µM 0.139033166730898 0.442761202723298 no 1468 0.444711970151485 2143 1494643 SGTC_2264 7948757 110.76 µM 0.137506390618968 0.443400397015251 no 1469 0.445315270872513 2063 2971411 SGTC_1202 1988-0068 29.6 µM 0.136045273500438 0.444012240725411 no 1470 0.445892745286824 1997 2850480 SGTC_222 nsc-310342 10.666 µM 0.135408996452541 0.444278723940132 no 1471 0.446144255752335 2175 432556 SGTC_236 1509-0011 5.31 µM 0.134139815633987 0.444810352711134 no 1472 0.446646007904613 2134 3107280 SGTC_531 3788-1495 174 µM 0.134110744232894 0.444822531176098 no 1473 0.446657501863486 2020 2896655 SGTC_1836 st055642 81 µM 0.13292336563946 0.445319987032191 no 1474 0.447126993883014 2012 8571 SGTC_941 3237-0776 460 µM 0.132724206470896 0.44540343382288 no 1475 0.447205749116555 2154 760008 SGTC_2969 9091408 28.7 µM 0.132311683419182 0.445576286805676 no 1476 0.447368883295211 1934 4286311 SGTC_2374 9071832 200 µM 0.131669908619413 0.445845220063394 no 1477 0.447622693846534 2165 17381698 SGTC_2960 9079389 5.97 µM 0.131498216864305 0.445917171061873 no 1478 0.447690598531512 2168 16457355 SGTC_376 3970-0862 59.1 µM 0.129491873178861 0.446758102479029 no 1479 0.448484227538241 2177 3135186 SGTC_1081 sertraline 6 µM 0.12853740805564 0.447158237724899 no 1480 0.448861848197163 2181 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_340 k038-0059 454 µM 0.128324616879364 0.447247452365259 no 1481 0.448946042351608 2119 23733424 SGTC_677 0929-0063 136 µM 0.127938080762178 0.447409517981126 no 1482 0.449098987285874 2188 1539583 SGTC_3129 9127257 49.47 µM 0.126883523667669 0.447851713856754 no 1483 0.449516293720474 1947 837894 SGTC_846 0335-0850 148 µM 0.126689950703341 0.447932889744488 no 1484 0.44959289996119 2187 6819598 SGTC_2492 derrusnin 100 µM 0.125551251535622 0.448410453537291 no 1485 0.450043576565884 2085 1715307 Part of coumarin class of compounds. SGTC_3109 9122853 49.47 µM 0.125396934919396 0.448475178794897 no 1486 0.450104657271533 2125 1234709 SGTC_1907 st060210 83.7 µM 0.125325212336724 0.44850526197592 no 1487 0.450133046489549 2155 688793 SGTC_1555 citronellol 128 µM 0.124967525700284 0.448655293782395 no 1488 0.45027462974766 2197 8842 A terpine precursor. SGTC_382 3229-0966 23.2 µM 0.124786070559153 0.448731408024668 no 1489 0.450346457636525 2173 5722370 SGTC_1249 0481-0015 10.2 µM 0.124419374714262 0.448885230180679 no 1490 0.450491616867704 2114 4227577 SGTC_95 0471-0001 561.058 µM 0.122723584950145 0.449596682335039 no 1491 0.451162993475042 1998 4015405 SGTC_3159 9100096 49.47 µM 0.121427338723748 0.450140619275272 no 1492 0.451676281960539 2178 25236875 SGTC_3168 9103419 49.47 µM 0.120625992432034 0.45047693089843 no 1493 0.451993640092949 2199 16649256 SGTC_894 0960-0238 55.9 µM 0.120428240132025 0.450559929708287 no 1494 0.452071960900554 2178 6741907 YDL195W SEC31 SGTC_1731 st035964 63 µM 0.120214258950012 0.45064974239343 no 1495 0.452156711340725 1993 6739575 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.120209959297017 0.450651547079815 no 1496 0.45215841430481 2179 91467 include heat shock SGTC_1218 1348-1416 30.7 µM 0.119932874978767 0.450767849381503 no 1497 0.452268160979102 2149 6787668 SGTC_2651 TUB2.036 5 µM 0.119232895531687 0.4510616748571 no 1498 0.452545422834708 2185 15992207 YFL037W TUB2 SGTC_18 0111-0177 500 nM 0.117973283000836 0.451590481040498 no 1499 0.453044413551862 2160 721752 SGTC_1976 st070609 63.5 µM 0.117810137296293 0.451658978610928 no 1500 0.453109048543636 2185 682556 SGTC_834 0312-0008 75.7 µM 0.116771598338472 0.452095048236507 no 1501 0.453520525493978 2184 6385573 YIL048W NEO1 SGTC_70 0141-0289 43.283 µM 0.116327459429141 0.452281554330124 no 1502 0.453696511931881 2086 352408 SGTC_509 pifithrin 175 µM 0.115472892559215 0.452640439954141 no 1503 0.454035152667023 2210 4817 A p53 inhibitor. SGTC_3019 9081971 49.47 µM 0.114479041054763 0.453057868482122 no 1504 0.454429029988226 2187 16451803 SGTC_572 0960-0087 17.7 µM 0.113536019286694 0.453453995937162 no 1505 0.454802804212969 2152 6796365 SGTC_2232 chlorophetanol 41.5365 µM 0.113354154144906 0.453530395882101 no 1506 0.45487489253087 2202 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_673 1082-0474 110 µM 0.11271236183434 0.453800020906261 no 1507 0.455129300190267 2161 3098046 SGTC_2304 7443016 91.4 µM 0.112631134186299 0.453834147183834 no 1508 0.455161500294431 2169 939854 SGTC_2605 digitonin 300 nM 0.111440904062847 0.454334239076129 no 1509 0.455633362649378 2220 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_91 0417-1751 58.384 µM 0.110215081920978 0.454849361126924 no 1510 0.45611940074993 2221 6795624 SGTC_2321 7390090 138.78 µM 0.110181526813067 0.454863462919605 no 1511 0.456132706266556 2069 649046 SGTC_2369 9071472 200 µM 0.109702628580919 0.455064729782769 no 1512 0.456322607847513 2145 17296037 SGTC_1605 st000082 49.1 µM 0.108937689749205 0.455386235016181 no 1513 0.456625956213008 2178 1114022 SGTC_164 4100-3994 89.624 µM 0.108633408164239 0.455514133275576 no 1514 0.456746630835613 2215 4615967 SGTC_3335 9143315 29.6265 µM 0.10860735926111 0.455525082589575 no 1515 0.456756961720422 2093 4899691 SGTC_3162 9099653 49.47 µM 0.10853366387669 0.45555605965859 no 1516 0.456786189156482 2209 25237511 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.107484736111202 0.455996994462905 no 1517 0.457202216993327 2210 2346 DNA damaging agent; causes G2/M arrest. SGTC_2489 cantharidin 73.42 µM 0.107283961676229 0.456081399642113 no 1518 0.457281853915347 2213 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1395 3486-0190 4.35 µM 0.105698948021553 0.456747805558052 no 1519 0.457910607516916 2218 6748079 SGTC_2835 9006588 71.43 µM 0.104665989279836 0.457182170136762 no 1520 0.458320425154774 2045 2345538 SGTC_2805 7950783 58.44 µM 0.10420450662431 0.457376242581973 no 1521 0.458503528838095 2142 1178958 YDL195W SEC31 SGTC_3063 1327-0034 4 µM 0.103752312499968 0.457566418677902 no 1522 0.458682955628136 2201 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.103346054109025 0.45773728419352 no 1523 0.45884416268906 2197 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2744 captopril 92.04 µM 0.101209746170537 0.458635907550816 no 1524 0.459691980061445 2232 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2526 patulin 37.61 µM 0.100775934989899 0.458818413239249 no 1525 0.459864165332413 2161 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_457 grayanotoxin iii 135 µM 0.0997539524121618 0.459248398675727 no 1526 0.460269833140352 2150 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2037 5169046 200 µM 0.0968303925290713 0.460478708776312 no 1527 0.461430543794356 2162 5718022 SGTC_1854 st056233 32.9 µM 0.0964194560537808 0.460651672148014 no 1528 0.461593720208848 2245 5393174 SGTC_2097 5376186 200 µM 0.0952471660525451 0.461145130408732 no 1529 0.462059253578222 2221 742755 SGTC_3200 9114385 49.47 µM 0.094951450475763 0.461269617017942 no 1530 0.462176694759936 2122 17018030 YLR208W SEC13 SGTC_416 estradiol valerate 100 µM 0.0940243532252929 0.461659919255056 no 1531 0.462544905677074 2132 13791 A steroid. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0905197632471832 0.463135660583944 no 1532 0.463937094810895 2254 756377 SGTC_2425 5628681 7.85 µM 0.0901206817903254 0.463303741622814 no 1533 0.464095657199922 2198 5714958 SGTC_1512 0259-0544 12.2 µM 0.0900292720396649 0.46334224156817 no 1534 0.46413197677556 2141 18476 SGTC_105 0111-0055 734.78 µM 0.0897618175749205 0.463454889970929 no 1535 0.464238245411121 2169 5179370 SGTC_2639 lactacystin 53 µM 0.088797790701626 0.463860950022081 no 1536 0.464621306760597 2213 3870 A proteasome inhibitor. SGTC_1855 st056195 39.6 µM 0.0881771159048237 0.464122405878624 no 1537 0.464867952660473 2266 4028379 SGTC_2982 9019404 25.97 µM 0.0877516185488925 0.46430165326657 no 1538 0.465037046077947 2062 22333232 SGTC_3053 9095903 49.47 µM 0.086651092936529 0.464765300337466 no 1539 0.465474426152352 2255 17174018 SGTC_1306 1185-0270 9.02 µM 0.0859671428021633 0.465053469960076 no 1540 0.465746268373186 2229 1548076 SGTC_1992 st073643 23.3 µM 0.084557852263879 0.465647305848252 no 1541 0.466306454014032 2262 3161292 SGTC_921 1561-0023 372 µM 0.0836975063754733 0.466009869400494 no 1542 0.466648469907177 2281 24050882 SGTC_393 acivicin 6.25 µM 0.083278858398715 0.466186304593366 no 1543 0.466814905222455 2193 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0825304427625554 0.466501733755079 no 1544 0.467112455538438 2234 688751 SGTC_194 1486-1323 56.904 µM 0.0822625944668099 0.466614626903621 no 1545 0.467218949430319 2149 5178754 SGTC_1076 itraconazole 331 nM 0.0822395224414517 0.466624351465312 no 1546 0.467228122754335 2262 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2853 9015042 58.44 µM 0.0813945264716122 0.466980520069415 no 1547 0.467564100956188 2239 6457456 SGTC_3233 9132340 49.47 µM 0.0802807052859216 0.467450039744896 no 1548 0.468007001813868 2221 17682950 SGTC_2218 6965428 192.983 µM 0.0800312670112875 0.46755519407182 no 1549 0.468106194120929 2232 675684 SGTC_3320 9137005 35.139 µM 0.0788986374000454 0.468032698905489 no 1550 0.46855662353092 2108 4908713 SGTC_24 0417-1663 219 µM 0.0783724549264954 0.468254547639683 no 1551 0.468765891952399 2178 4329390 SGTC_647 0140-0236 81 µM 0.0779058799482256 0.468451272947121 no 1552 0.468951461053533 2202 990837 SGTC_2099 5377090 177.372 µM 0.0775515988544301 0.468600656138365 no 1553 0.46909237244048 2180 2243829 SGTC_3208 9114115 49.47 µM 0.0775029370717258 0.468621174802854 no 1554 0.469111727429189 2103 650895 SGTC_2106 5357045 167.29 µM 0.0768757071827178 0.468885659190257 no 1555 0.469361211601948 2232 668842 SGTC_1002 4049-0206 172 µM 0.0762284523305173 0.469158601910496 no 1556 0.469618673426316 2238 4662749 SGTC_1774 st048371 48.465 µM 0.076089566397785 0.46921717100353 no 1557 0.469673920442711 2239 4242727 SGTC_2306 7482397 179.52 µM 0.0760343791779226 0.469240443994864 no 1558 0.46969587336264 2249 891448 SGTC_2963 9082507 9 µM 0.0756878022118743 0.469386601296429 no 1559 0.469833740290283 2232 16459611 SGTC_2800 7887935 81.82 µM 0.0755385188667542 0.469449557851466 no 1560 0.469893125721825 2194 2961002 SGTC_1991 st073000 8.92 µM 0.0754180079787452 0.469500380892277 no 1561 0.469941065858877 2247 4301969 YIL048W NEO1 SGTC_1072 oxiconazole 14.9 nM 0.0751137065436772 0.469628716105884 no 1562 0.470062121194612 2287 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2957 9076800 11.52 µM 0.0736251279314253 0.47025655019655 no 1563 0.47065433809999 2206 16459615 SGTC_1026 k007-1105 30.6 µM 0.072747756579213 0.470626631661399 no 1564 0.471003422471323 2275 7066794 SGTC_469 w7 172 µM 0.0724158375836462 0.470766644081727 no 1565 0.471135490657807 2282 45115570 A P450 inhibitor. SGTC_2566 crystal violet carbinol 226 nM 0.0721032221501147 0.470898517041803 no 1566 0.471259880998631 2061 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_871 0574-0004 149 µM 0.0716237403612937 0.471100786709181 no 1567 0.471450673258484 2144 9551173 SGTC_1762 st045503 25.4615 µM 0.0709451058252576 0.471387081808008 no 1568 0.471720722267483 2210 4645554 SGTC_1267 0828-0272 9.49 µM 0.0704489956768208 0.471596384829904 no 1569 0.471918147589335 2259 745334 SGTC_784 4579-0127 173 µM 0.0699813641066593 0.471793680258823 no 1570 0.472104246277515 2284 1948547 SGTC_944 3370-0224 231 µM 0.067908308100708 0.472668392682036 no 1571 0.472929312557349 2244 4580514 SGTC_2946 9065502 71.43 µM 0.0660853556014149 0.473437684635632 no 1572 0.473654934950009 2304 16489101 SGTC_2908 7930301 100 µM 0.0658949716497477 0.473518033052939 no 1573 0.47373072196303 2290 2223178 SGTC_2147 5545932 89.7195 µM 0.0653728996822188 0.47373837046338 no 1574 0.473938550416388 2219 797404 SGTC_540 1187-0821 17.3 µM 0.0651327489921492 0.473839727354908 no 1575 0.474034152928827 2198 847520 SGTC_2406 ethylparaben 405.7 µM 0.0633563651543391 0.474589511875959 no 1576 0.474741366484617 2015 8434 A possible steroid mimic. SGTC_171 k064-0041 9.68 µM 0.0629169853568411 0.474774981373984 no 1577 0.474916304641166 2201 53325 SGTC_2261 9010538 184.68 µM 0.0622291666981481 0.475065331996813 no 1578 0.475190167914099 2146 6457250 SGTC_1071 trifluoperazine 6.31 µM 0.0611608464438002 0.475516330918484 no 1579 0.475615555670382 2260 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2519 cryptotanshinone 88.04 µM 0.0605961212709325 0.475754746339816 no 1580 0.475840431313411 2299 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1077 5-fluorocytosine 377 nM 0.0603950375767264 0.475839641864288 no 1581 0.475920505442403 2246 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2322 7413319 38.22 µM 0.0583355931684755 0.476709181152239 no 1582 0.47674065826428 2245 1840400 SGTC_1572 epiandrosterone 68.9 µM 0.0578817394814297 0.47690082246276 no 1583 0.476921414257962 2243 441302 A steroid. SGTC_1408 3909-7976 48.8 µM 0.0575581244672949 0.477037473302408 no 1584 0.477050303087784 2258 24152374 SGTC_984 1492-0255 2.91 µM 0.0557412933356126 0.47780470462493 no 1585 0.47777395164841 2247 1585198 SGTC_3301 9125354 19.7965 µM 0.0541321622005383 0.478484294910676 no 1586 0.478414934037134 2292 41905162 SGTC_3274 9138298 49.47 µM 0.0533060649676366 0.478833208029073 no 1587 0.478744023964485 2319 17015756 SGTC_128 0906-2981 13.371 µM 0.0520743831649951 0.479353455210312 no 1588 0.479234712268528 2311 6740226 SGTC_1179 1021-1431 9.29 µM 0.0510658393286598 0.479779477904897 no 1589 0.479636528363864 2253 2840958 SGTC_452 diindolylmethane 8 µM 0.0508477972690355 0.479871584903187 no 1590 0.479723401699399 2293 3071 Inhibits expression of several cancer promoting factors. SGTC_2257 7960413 200 µM 0.050535213309835 0.480003630889027 no 1591 0.479847944539126 2253 2974689 YIL048W NEO1 SGTC_1699 st031318 29.054 µM 0.050415577779857 0.480054169545225 no 1592 0.479895611449495 2289 5340658 SGTC_1455 4262-0120 131 µM 0.0497754219550094 0.480324601452306 no 1593 0.480150676418534 2287 1529587 SGTC_716 1683-5115 658 µM 0.0492658816764867 0.480539861692763 no 1594 0.48035370448198 2334 723597 SGTC_1702 st027038 51 µM 0.0478178580399558 0.481151624112794 no 1595 0.480930702089135 2243 5521182 SGTC_3018 9082602 49.47 µM 0.0475520629874208 0.481263922327023 no 1596 0.481036618485434 2264 17332089 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0474519211308405 0.481306232573872 no 1597 0.481076524258162 2319 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0471456983646684 0.481435613952439 no 1598 0.481198552890112 2271 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_55 0767-0285 6.563 µM 0.0468757306860339 0.481549678911262 no 1599 0.481306135466291 2331 3116166 SGTC_1666 st014829 29 µM 0.0458981439756617 0.481962734955046 no 1600 0.481695716756397 2312 3858230 SGTC_1404 3909-7820 48.3 µM 0.0454760938322339 0.482141068228483 no 1601 0.481863914769243 2320 23741373 SGTC_2128 5255449 168.493 µM 0.0454334122175031 0.482159103138345 no 1602 0.481880924688483 2322 736008 SGTC_2778 tioconazole 65.09 nM 0.0443866289462861 0.482601427683869 no 1603 0.482298109850103 2306 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_46 0329-0187a 2.197 µM 0.044368123747635 0.482609247360726 no 1604 0.482305485090454 2272 46494817 SGTC_2801 7907800 81.82 µM 0.0440817388199874 0.482730264885712 no 1605 0.482419624472134 2289 6620925 SGTC_1173 0443-0020 122 µM 0.0433273481058145 0.483049054951508 no 1606 0.482720295525718 2286 5331295 SGTC_2291 7917025 104.35 µM 0.0414692515304527 0.483834294305829 no 1607 0.483460902741387 2310 2964612 SGTC_3236 9132701 49.47 µM 0.0410486010407254 0.484012071768728 no 1608 0.483628575230667 2287 24282524 SGTC_2822 7994718 71.43 µM 0.040546207488397 0.484224400064896 no 1609 0.483828834530009 2335 1018011 SGTC_2851 9015922 71.43 µM 0.0398515478783028 0.484517993775552 no 1610 0.484105739790494 2321 2996893 SGTC_3152 9099253 49.47 µM 0.0392761307896359 0.48476119671389 no 1611 0.484335118399729 2301 25236131 SGTC_2320 7373003 200 µM 0.039203737530547 0.484791794493758 no 1612 0.484363976905268 2295 5415828 SGTC_177 1327-0068 8.361 µM 0.0370164200378623 0.485716328865505 no 1613 0.485235956707899 2357 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_991 3996-0057 64.7 µM 0.0365035026777838 0.485933139841406 no 1614 0.485440442919689 2313 715343 SGTC_1531 st059297 52.4 µM 0.03557699780628 0.486324785405598 no 1615 0.485809824899749 2321 7566702 SGTC_1785 bathophenanthroline 24 µM 0.0354491710227775 0.486378820480341 no 1616 0.485860788261122 2295 72812 An iron chelator. SGTC_3100 9120536 49.47 µM 0.0349496160864632 0.486589995266941 no 1617 0.486059958420659 2361 16421196 SGTC_965 1291-5240 308 µM 0.0349369276679029 0.486595359038719 no 1618 0.486065017277837 2341 2834598 SGTC_2353 9059630 146.67 µM 0.0347062733677284 0.486692863890971 no 1619 0.486156979259257 2312 4779114 SGTC_808 0711-0032 135 µM 0.0346722413873184 0.486707250350642 no 1620 0.486170547888803 2352 4252555 SGTC_1955 wogonin 32.4 µM 0.0344745320931206 0.486790829042749 no 1621 0.486249375359288 2324 5281703 A flavanone. SGTC_1416 3966-0321 25.3 µM 0.0343974663580258 0.486823407604531 no 1622 0.486280101915618 2329 582530 YLR208W SEC13 SGTC_1891 st059073 26.2 µM 0.0328053070550365 0.487496492106561 no 1623 0.48691492303712 2351 688754 SGTC_1196 1588-0294 184 µM 0.0321275627233772 0.487783019082693 no 1624 0.4871851614386 2286 6144269 SGTC_1215 3852-0577 11.2 µM 0.0317747913162006 0.487932161196362 no 1625 0.48732582504901 2342 2884876 SGTC_873 0591-4978 488 µM 0.0317082073474587 0.487960311269313 no 1626 0.487352374831209 2339 3305145 SGTC_3073 9114972 49.47 µM 0.0316907313873785 0.487967699687615 no 1627 0.487359343228576 2354 41905075 SGTC_2727 riluzole 51.77 µM 0.0301826821366519 0.488605282154933 no 1628 0.48796067994618 2361 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1945 st075991 56.6 µM 0.0299916919850361 0.488686032273806 no 1629 0.488036839513583 2271 1084980 SGTC_1896 st058441 89 µM 0.0298349165605223 0.488752316845466 no 1630 0.488099355882623 2245 688759 SGTC_2874 9043904 71.43 µM 0.0286120963404389 0.489269335146914 no 1631 0.488586982275195 2241 4463428 SGTC_3289 9119912 71.43 µM 0.0285929251950421 0.489277441008428 no 1632 0.488594627327795 2334 17014829 SGTC_2738 aclarubicin 5.55 µM 0.028168740631919 0.489456794034084 no 1633 0.488763784344138 2345 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1475 4092-1048 11.7 µM 0.0280630610644923 0.489501477629698 no 1634 0.488805927731192 2278 2881759 SGTC_2223 6903751 107.57 µM 0.0275832520600801 0.489704352852437 no 1635 0.488997269751787 2348 5598863 SGTC_866 0495-0101 262 µM 0.0275042074891139 0.489737775126896 no 1636 0.489028792013612 2336 635694 SGTC_2289 7946404 165.07 µM 0.0274418614092226 0.489764136859107 no 1637 0.489053655116191 2328 1246120 YPR165W RHO1 SGTC_2828 7998861 71.43 µM 0.0257734653909379 0.490469599363077 no 1638 0.489719013183478 2357 2988188 SGTC_2053 5265679 138 µM 0.0243987972556614 0.491050884833283 no 1639 0.490267253846106 2367 764595 SGTC_3142 9086498 49.47 µM 0.0224374637106898 0.491880277380571 no 1640 0.491049498073584 2364 25236367 SGTC_2455 5377712 9.75 µM 0.0224146660719424 0.491889918071293 no 1641 0.491058590728809 2274 2243908 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0221763802059026 0.4919906849447 no 1642 0.491153629411027 2359 140250 A respiratory chain inhibitor. SGTC_1112 tnp00069 1.16933 µM 0.022151852568741 0.492001057277266 no 1643 0.491163412119366 2355 145826 SGTC_2753 fluvastatin 17.09 µM 0.021192939476875 0.492406569952122 no 1644 0.491545873250134 2335 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2058 5236698 133 µM 0.0209610479203193 0.49250463526311 no 1645 0.491638364049982 2347 766665 SGTC_3251 9135047 49.47 µM 0.0201567485869086 0.492844771276326 no 1646 0.491959165248121 2374 17682963 SGTC_3108 9121785 49.47 µM 0.0195764858112826 0.493090166079899 no 1647 0.492190610921532 2374 17140271 SGTC_1440 4100-1550 40 µM 0.019048978930645 0.493313252534743 no 1648 0.49240101647462 2359 742806 SGTC_232 clozapine 119 µM 0.0174885231828933 0.493973192473962 no 1649 0.493023444310492 2383 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2407 paclitaxel 400 µM 0.0168846153702932 0.494228598593992 no 1650 0.493264333087473 2308 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_987 1497-1013 404 µM 0.0166419832950202 0.494331213797054 no 1651 0.493361115681337 2365 1676435 SGTC_796 1234-0020 70.7 µM 0.0161903160513523 0.494522236220689 no 1652 0.493541280562028 2384 46495034 SGTC_683 panaxydol 45 µM 0.0157222818816554 0.494720181989326 no 1653 0.493727975411197 2365 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1754 st042065 16.137 µM 0.0150437563659805 0.495007153193147 no 1654 0.493998635896464 2362 1126236 YIL048W NEO1 SGTC_539 4859-0462 2.54 µM 0.0148041127462887 0.495108507144572 no 1655 0.494094229222311 2372 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2470 5664817 21.68 µM 0.0127838114433215 0.495962977519996 no 1656 0.494900136019213 2384 2859561 SGTC_2716 st080858 38.6235 µM 0.0124469752136908 0.496105441632914 no 1657 0.495034503539552 2380 5296050 SGTC_937 3122-0005 46.7 µM 0.0124142095298407 0.496119299830757 no 1658 0.495047574146314 2377 759535 SGTC_291 SEC14.278 35.5 µM 0.0123304264272421 0.496154735792158 no 1659 0.495080996210187 2381 1068044 SGTC_2237 6667747 47.222 µM 0.01168967315775 0.496425742591431 no 1660 0.495336601341248 2303 729940 YDL015C TSC13 SGTC_2594 a-mangostin 100 µM 0.0113165135021486 0.496583571354599 no 1661 0.4954854606554 2383 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2148 5546263 113.568 µM 0.0111076358085773 0.496671916906523 no 1662 0.495568785561069 2375 792097 SGTC_829 1635-0120 117 µM 0.0100808940753473 0.497106183208715 no 1663 0.495978373245129 2385 285054 SGTC_2396 5342950 42.78 µM 0.00957382369801499 0.497320652828715 no 1664 0.496180655287489 2371 1886677 SGTC_2694 st077685 81.9 µM 0.00926364670868278 0.49745184514358 no 1665 0.496304392513799 2380 2838096 SGTC_2122 5258151 111.688 µM 0.00896080689900496 0.497579934394338 no 1666 0.496425203101889 2378 2173356 SGTC_3177 9107506 49.47 µM 0.00891853351097958 0.49759781438411 no 1667 0.496442067069829 2388 8897194 SGTC_804 1595-0054 20.9 µM 0.00763358574823498 0.498141299166478 no 1668 0.496954669470051 2383 761523 Stimulates phospholipase C. SGTC_2791 5663188 71.43 µM 0.00757744556357394 0.498165044448123 no 1669 0.496977065515593 2388 54690634 SGTC_2420 aureobasidin a 50 nM 0.00556895519094269 0.499014567369023 no 1670 0.49777831980027 2389 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_281 1672-3440 14.9 µM 0.00533314878384751 0.499114305803653 no 1671 0.497872391548199 2378 6833000 SGTC_853 0419-0306 21 µM 0.004981834002945 0.499262900621359 no 1672 0.49801254400329 2394 762713 SGTC_1106 tegaserod maleate 11.7 µM 0.00482082114527193 0.499331003900748 no 1673 0.498076778068282 2379 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2442 5158906 48.48 µM 0.00447252249179015 0.49947832313455 no 1674 0.498215727626583 2390 1893835 SGTC_2689 tacrolimus 100 µM 0.00386456872981327 0.499735468365256 no 1675 0.498458263975771 2394 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_375 3970-0961 9.27 µM 0.00383638458308728 0.499747389372225 no 1676 0.498469507740186 2389 2898222 SGTC_276 colchicine 750 µM 0.00373009013274843 0.499792348581042 no 1677 0.498511912787107 2383 2833 A microtubule depolymerizer. SGTC_792 4534-1957 155 µM 0.00344311438270486 0.499913730307545 no 1678 0.498626398810497 2378 1717904 SGTC_1503 4585-0012 61.3 µM 0.00303518958497674 0.499913730307545 no 1679 0.498789136404674 2394 2922052 SGTC_2736 butenafine 14.65 µM 0.00298556006795275 0.499892738580143 no 1680 0.498808935627655 2396 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2337 9009472 200 µM 0.000167663510564652 0.498700859074113 no 1681 0.499933111937069 2404 5742383 SGTC_450 aminopyrene 156 nM 0.000132230199963508 0.49868587197623 no 1682 0.499947247782642 2404 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_659 k018-0002 107 µM 0 0.498629943068373 no 1683 0.5 2405 6797879 YHR007C ERG11 SGTC_1176 0848-0131 83.3 µM 0 0.498629943068373 no 1684 0.5 2405 6769040 SGTC_1452 4194-0072 190 µM -0.000119967670591054 0.49857920081948 no 1685 0.499952139824035 2407 1343545 SGTC_1018 4259-0013 28.1 µM -0.000277002078755324 0.498512780634759 no 1686 0.499889492160439 2406 6801262 SGTC_2565 isoliquiritigenin 100 µM -0.00125636317086815 0.498098545385719 no 1687 0.499498783743459 2405 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2094 5332512 191.667 µM -0.0013664676688364 0.49805197518087 no 1688 0.499454858441751 2407 755774 SGTC_271 rotenone 740 µM -0.0024024129633133 0.497613809322483 no 1689 0.499041576815887 2425 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_6 0844-0013 19.835 µM -0.00472397454361414 0.496631887423515 no 1690 0.498115413832399 2415 1584900 SGTC_1417 3966-0327 90.4 µM -0.00511529504354142 0.496466377327543 no 1691 0.497959301429977 2416 651118 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.00600092625127273 0.49609179943042 no 1692 0.497605991165293 2413 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2665 lovastatin 100 µM -0.00611953316533042 0.49604163486669 no 1693 0.497558674721444 2418 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1343 1487-0095 224 µM -0.00640031042390498 0.495922880921917 no 1694 0.497446662996694 2410 4560101 YGL055W OLE1 SGTC_895 0964-0006 13.7 µM -0.00678727884076212 0.495759214322348 no 1695 0.497292288290991 2403 6738897 SGTC_2746 daunorubicin 9.88 µM -0.00719816831419558 0.495585431198488 no 1696 0.497128371116294 2418 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1245 0418-0076 17.2 µM -0.00745638319877716 0.495476221260297 no 1697 0.497025361046981 2431 6790114 SGTC_431 k089-0097 107 µM -0.00770178854303468 0.495372429329723 no 1698 0.496927461291412 2418 5499420 SGTC_2024 5144227 134 µM -0.00853165787930261 0.49502144609775 no 1699 0.496596402240928 2424 3475211 SGTC_2437 5741531 144.16 µM -0.00862132001300088 0.494983524805002 no 1700 0.496560633540385 2426 2262990 SGTC_2329 6138490 200 µM -0.00870020965256218 0.494950159619131 no 1701 0.496529162308019 2465 720019 SGTC_1518 st038567 90.8 µM -0.00892799457216058 0.494853821614321 no 1702 0.496438292802772 2419 77966 SGTC_888 0916-0002 6.97 µM -0.00932353135060409 0.494686536348197 no 1703 0.496280503029893 2436 2802138 YIL048W NEO1 SGTC_1622 st003707 19.4 µM -0.00959423572367438 0.49457204727098 no 1704 0.496172512441408 2466 10140899 SGTC_49 0717-0965 32.132 µM -0.00988252919667939 0.494450119722576 no 1705 0.496057505439797 2505 5889349 YGL099W LSG1 SGTC_788 1182-0090 188 µM -0.0107580207014438 0.494079852571305 no 1706 0.495708253473141 2459 5715185 SGTC_1559 coumarin 343 70.1 µM -0.0111201463946885 0.493926702074008 no 1707 0.495563794867548 2433 108770 A hepatotoxic, DNA x-linker. SGTC_517 1365-0151 113 µM -0.0125961543453971 0.493302477071978 no 1708 0.49497499434201 2465 768657 SGTC_1113 artemisinin 1.17947 µM -0.0142345987055258 0.492609574647303 no 1709 0.494321408502097 2434 2240 An anti-malaria and mitochondrial poison. SGTC_205 1486-1330 71.903 µM -0.0145864740264437 0.492460768486911 no 1710 0.494181045134812 2420 4118834 SGTC_278 4092-0821 23.9 µM -0.0146748661216076 0.492423388114442 no 1711 0.494145785564782 2440 877900 SGTC_2100 5377183 190 µM -0.0147462694835798 0.492393192201921 no 1712 0.494117302826745 2457 2844202 SGTC_1386 3228-0095 33.8 µM -0.0148965817605434 0.492329626481016 no 1713 0.494057343490392 2439 870181 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0155863704955594 0.492037923501653 no 1714 0.493782189566245 2458 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2756 carbadox 75.1 µM -0.015679029125463 0.491998739653563 no 1715 0.493745228637702 2443 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_566 0958-0068 16.5 µM -0.0168254000890755 0.49151396426914 no 1716 0.493287953211419 2440 6815365 SGTC_2878 9043973 25.97 µM -0.0177113562558038 0.491139321196083 no 1717 0.49293456054371 2498 6465167 SGTC_363 0455-0021 3.06 µM -0.018512059889121 0.490800735460681 no 1718 0.49261517840723 2447 4597466 SGTC_16 erodoxin 22.806 µM -0.0200930286558206 0.490132226316296 no 1719 0.491984580675445 2455 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1913 st060213 96.1 µM -0.0207952228583921 0.489835313829898 no 1720 0.491704504261544 2449 688959 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0217591231193984 0.489427751993444 no 1721 0.4913200507426 2464 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2622 2-methoxyxanthone 59.94 µM -0.0226364795755502 0.489056792690537 no 1722 0.490970122391365 2473 71034 A hepatoprotective. SGTC_2376 9072922 81.32 µM -0.022883833765774 0.488952209372488 no 1723 0.490871467902943 2524 17087968 SGTC_1454 4239-0054 42.6 µM -0.0235480299287515 0.488671385732954 no 1724 0.490606563374593 2515 1340767 SGTC_1480 1070-0044 41.2 µM -0.0237179997388774 0.488599523009871 no 1725 0.490538774164462 2522 3124987 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0242944886358559 0.488355788013358 no 1726 0.490308854633289 2438 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_664 1222-0054 14.9 µM -0.0248397270748217 0.488125269466083 no 1727 0.490091401600785 2462 6813991 SGTC_1750 st081859 2.357 µM -0.0254867261005246 0.487851733238122 no 1728 0.489833368043359 2462 5291695 SGTC_1126 isoteolin 1.0172 µM -0.0255904856200674 0.48780786664078 no 1729 0.489791987480861 2449 133323 SGTC_1711 st032263 62.8 µM -0.0261204460768141 0.487583816624201 no 1730 0.489580634507277 2479 3958979 SGTC_1304 1165-0502 251 µM -0.0277669602272276 0.48688774939613 no 1731 0.488924008857813 2475 767425 SGTC_883 0850-0245 24.6 µM -0.0278590231403472 0.48684883077058 no 1732 0.488887295272199 2579 6823229 YPR165W RHO1 SGTC_599 1935-0052 86.5 µM -0.0295811641120801 0.486120837325689 no 1733 0.488200543800345 2463 9557311 SGTC_2954 9074818 52.69 µM -0.0299932615388165 0.485946639872186 no 1734 0.488036213633786 2494 16648742 SGTC_2944 9067346 25.62 µM -0.0301312841042278 0.485888297035043 no 1735 0.487981175472559 2470 6473075 SGTC_2199 6590217 200 µM -0.0321961531377592 0.485015503196298 no 1736 0.487157811970878 2476 703109 SGTC_2165 5727197 32.143 µM -0.0332673423789542 0.484562753162942 no 1737 0.486730698171837 2643 1361712 SGTC_145 3737-0113 38.366 µM -0.0335529981409727 0.484442020918694 no 1738 0.486616801596784 2491 6849351 SGTC_840 0245-0196 390 µM -0.0338313717699189 0.484324367835964 no 1739 0.486505809601709 2543 3827528 SGTC_1569 carminic acid 40.6 µM -0.034450808925785 0.484062571042247 no 1740 0.486258833915246 2465 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0346833288352435 0.483964301393136 no 1741 0.486166127295833 2479 6857784 SGTC_231 b-estradiol 524 µM -0.0349483063645577 0.483852315401479 no 1742 0.4860604806051 2459 450 A steroid. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0357247071844177 0.483524196771997 no 1743 0.485750934819699 2468 16725076 SGTC_295 k015-0027 31 µM -0.0359037705451927 0.483448523485784 no 1744 0.485679544673627 2514 3887424 SGTC_1591 genipin 88.4 µM -0.0361671061142586 0.483337237325872 no 1745 0.48557455716954 2573 442424 A DNA cross-linking agent. SGTC_2950 9072895 21.46 µM -0.036170399686119 0.483335845463745 no 1746 0.485573244083628 2494 17332245 SGTC_1506 4226-2149 212 µM -0.0382958249427805 0.48243768472584 no 1747 0.484725909779639 2533 991114 SGTC_1328 1441-0025 69.2 µM -0.0388777797975594 0.482191777994795 no 1748 0.4844939161628 2468 4562601 SGTC_1967 st070177 51.4 µM -0.0390979203815924 0.48209875870632 no 1749 0.484406159499093 2512 5729214 SGTC_2772 vinpocetine 57.06 µM -0.0395040152393148 0.481927167942296 no 1750 0.48424427615965 2493 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2585 alliin 100 µM -0.0406533612711787 0.481441543098616 no 1751 0.483786121572874 2499 87310 A garlic compound which reacts with lipids. SGTC_972 1319-0219 195 µM -0.0408285320999941 0.481367531839138 no 1752 0.483716296495804 2502 23903702 SGTC_3312 9133330 71.43 µM -0.041067162411301 0.481266709408181 no 1753 0.48362117655395 2565 17617324 SGTC_1022 4477-0945 21.3 µM -0.0423103670266543 0.480741469128558 no 1754 0.483125640497941 2476 4648966 SGTC_1522 st012842 45.6 µM -0.0427448647972695 0.480557906435823 no 1755 0.482952457647784 2475 3491067 YOR116C RPO31 SGTC_1619 st003326 88.7 µM -0.0432403420792705 0.480348586703313 no 1756 0.48275497340877 2481 2849032 SGTC_280 3448-3607 3.04 µM -0.0462134746472026 0.4790926705452 no 1757 0.481570051367221 2482 626179 SGTC_2787 5284540 71.43 µM -0.0464120657483379 0.479008788581759 no 1758 0.481490909900309 2517 736958 SGTC_596 1155-0152 116 µM -0.046494544425356 0.47897395107339 no 1759 0.481458041151856 2490 280313 SGTC_2595 hexamethylquercetagetin 100 µM -0.0467805343616438 0.478853155318613 no 1760 0.481344071687527 2535 386331 SGTC_2270 7924575 90.91 µM -0.0469453176864311 0.478783555407839 no 1761 0.48127840479848 2525 1262135 SGTC_3102 9121669 49.47 µM -0.0478381620774886 0.478406453978756 no 1762 0.480922611209414 2517 41905072 SGTC_1317 1273-0028 910 nM -0.0492624684069759 0.477804924633955 no 1763 0.480355064528113 2506 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_818 4072-2707 53.5 µM -0.0500967462307589 0.477452606271846 no 1764 0.480022646308064 2498 882871 SGTC_1840 st055363 71 µM -0.0502959252437174 0.477368494892783 no 1765 0.479943285423269 2545 676033 SGTC_218 alverine citrate 93.75 µM -0.0516031005815584 0.476816512527091 no 1766 0.479422474363451 2565 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3349 9149703 23.001 µM -0.051970346732328 0.476661443049511 no 1767 0.479276160675778 2484 4910494 SGTC_999 SEC7.066 22.7 µM -0.0521687596336956 0.476577664784158 no 1768 0.479197112612312 2522 740511 YDR170C SEC7 SGTC_1758 st042942 75.2445 µM -0.0522697021518258 0.476535043007951 no 1769 0.479156897241955 2487 669317 SGTC_1052 3253-3998 198 µM -0.0540879796945901 0.475767343410311 no 1770 0.478432534521712 2497 5450317 SGTC_2004 4023728 41.89 µM -0.0546529214347561 0.475528836099404 no 1771 0.478207488259328 2518 360084 YDR527W RBA50 SGTC_3226 9131256 49.47 µM -0.0548558637551138 0.475443159972414 no 1772 0.478126647260681 2488 17178073 SGTC_2544 sphondin 68.51 µM -0.055289528164289 0.475260083748561 no 1773 0.477953902360246 2559 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_451 chloral hydrate 100 µM -0.0558618817062417 0.475018466376669 no 1774 0.47772591869004 2588 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2591 skatole 100 µM -0.0565516019116002 0.474727315225547 no 1775 0.477451194440955 2556 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2439 5492030 7.2 µM -0.057306913193343 0.474408491643176 no 1776 0.477150356736674 2532 5722370 SGTC_1843 st055809 45.5 µM -0.0577483140656039 0.474222179999442 no 1777 0.476974554410784 2616 16413835 SGTC_1342 1486-1464 234 µM -0.0580668784870102 0.474087720102161 no 1778 0.476847678498867 2494 3253938 SGTC_2323 6148992 148.28 µM -0.0590122657169834 0.473688707825568 no 1779 0.476471169254766 2557 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0592637154915276 0.473582584791377 no 1780 0.476371030569366 2527 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1427 4048-4900 550 nM -0.0596223533274673 0.473431226854191 no 1781 0.476228207328184 2553 24132586 SGTC_1229 0139-0193 12.2 µM -0.0609440285700438 0.472873466121627 no 1782 0.475701892431341 2514 3090752 SGTC_2980 9014342 25.29 µM -0.0622051777641873 0.472341297582146 no 1783 0.475199719609022 2657 2996599 SGTC_3186 9110464 49.47 µM -0.063763701899213 0.471683713712738 no 1784 0.474579190552398 2578 17018021 SGTC_96 0929-0093 37.281 µM -0.064031758243033 0.471570621154748 no 1785 0.474472469632655 2515 6991579 SGTC_2409 alverine citrate 63.97 µM -0.0642153936676515 0.471493146974911 no 1786 0.474399360159285 2803 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2022 5136654 200 µM -0.065964345462993 0.470755333984218 no 1787 0.473703105900692 2610 1713771 SGTC_2357 9067248 200 µM -0.0671370273129605 0.47026068235217 no 1788 0.473236308422981 2573 9150235 SGTC_900 1112-0045 141 µM -0.0713633381756097 0.468478358591499 no 1789 0.471554293542754 2547 56211 YIL048W NEO1 SGTC_3341 9147222 25.867 µM -0.071996140207792 0.468211546222203 no 1790 0.471302489774805 2608 1939759 SGTC_2312 7706453 155.7 µM -0.0729989044186268 0.467788773620498 no 1791 0.470903494666806 2559 976098 SGTC_1396 3511-0007 98.6 µM -0.0734617108146727 0.467593663340104 no 1792 0.470719356030058 2605 X1396 SGTC_2251 lansoprazole 556 µM -0.073927071149422 0.467397484218047 no 1793 0.470534207559804 2537 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2217 6934799 96.0675 µM -0.0747113472953962 0.46706687964278 no 1794 0.470222189536164 2549 675606 SGTC_359 0081-0058 15.9 µM -0.076233171105597 0.466425433479178 no 1795 0.469616796369273 2690 3494159 SGTC_2290 7904846 200 µM -0.0762799493453986 0.466405717903041 no 1796 0.469598188732633 2597 2962154 SGTC_111 0083-0039 52.457 µM -0.0767654636718498 0.466201093561149 no 1797 0.469405062816635 2528 759313 SGTC_2733 amorolfine 100 µM -0.076834404398633 0.466172038600284 no 1798 0.469377640437001 2570 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0793020800355684 0.46513216048606 no 1799 0.468396175942546 2547 688667 SGTC_1957 st077035 62.4 µM -0.0795088208530702 0.465045050648871 no 1800 0.468313957900167 2559 705593 SGTC_1807 st050092 58.9 µM -0.0814498142240607 0.464227299161708 no 1801 0.467542117326066 2560 5008496 SGTC_1212 0520-0165 585 µM -0.0823189973086586 0.463861156183667 no 1802 0.467196524010613 2788 5403258 SGTC_411 enrofloxacin 100 µM -0.0823342572543775 0.463854728210972 no 1803 0.46719045676884 2615 71188 A bacterial gyrase inhibitor. SGTC_1300 1094-0077 113 µM -0.0831276266455866 0.46352054891937 no 1804 0.466875029488742 2568 5532636 SGTC_1725 st036284 20.55 µM -0.083186345096523 0.463495816832084 no 1805 0.466851685070037 2636 707914 SGTC_1270 0831-1170 17.3 µM -0.0841084552910614 0.463107444534567 no 1806 0.466485101058691 2554 6764716 SGTC_225 nsc-122657 1.016 µM -0.086187128565261 0.462232083133555 no 1807 0.465658831274804 2670 275685 SGTC_1888 azatryptophan 97.5 µM -0.0862055192591075 0.462224339338496 no 1808 0.465651521654495 2671 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_930 2810-3379 265 µM -0.0882977118575553 0.461343471076095 no 1809 0.464820028763648 2646 1015764 SGTC_1243 0416-0003 5.65 µM -0.0883111599179505 0.461337809696691 no 1810 0.464814684640302 2624 2141977 SGTC_695 3505-6186 243 µM -0.0885579780348129 0.461233905324346 no 1811 0.46471660274224 2646 1819379 SGTC_289 k017-0060 526 µM -0.0885766138868905 0.461226060195146 no 1812 0.46470919721504 2573 5512909 SGTC_737 1950-0117 57.9 µM -0.0885899645058005 0.461220439998284 no 1813 0.464703891944801 2562 5393513 SGTC_1707 st032323 6.317 µM -0.0915274117626578 0.459984056030183 no 1814 0.463536763103895 2576 3132057 YMR211W DML1 SGTC_1530 rhein 70.4 µM -0.091650960501031 0.459932062237767 no 1815 0.463487680587119 2552 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_138 0850-0259 40.9225 µM -0.0930656591425531 0.459336754773748 no 1816 0.462925699515673 2571 6813004 SGTC_2093 5331342 194.4 µM -0.093125357351867 0.459311635666564 no 1817 0.462901986357174 2617 33839 SGTC_3292 9120825 59.784 µM -0.0940675985019479 0.458915192147298 no 1818 0.462527729434883 2567 24824900 SGTC_1307 1187-1599 12.2 µM -0.0942679347502347 0.458830906869443 no 1819 0.462448160410414 2580 1538471 SGTC_2804 7954240 19.48 µM -0.0945863719724628 0.458696938071319 no 1820 0.462321687445392 2664 828705 SGTC_191 3914-0123 66.505 µM -0.0965052352718446 0.457889758508256 no 1821 0.461559658094929 2574 3144412 SGTC_1190 1486-1332 13 µM -0.0968520346498034 0.457743894024753 no 1822 0.461421950228163 2564 4150046 SGTC_341 1486-1430 230 µM -0.0983053448104984 0.4571326911081 no 1823 0.460844917098268 2581 2054753 YPL210C SRP72 SGTC_2010 4012422 159 µM -0.0992577842166007 0.456732188883735 no 1824 0.460466798075933 2643 952393 SGTC_1525 8-methoxypsoralen 92.5 µM -0.0998759421647784 0.456472276014686 no 1825 0.460221408102033 2617 4114 Related to psoralen; DNA damaging agent. SGTC_300 r073-0011 5.04 µM -0.0999594758118763 0.456437154588912 no 1826 0.460188248935271 2588 2735780 SGTC_3199 9111318 49.47 µM -0.100231229981013 0.456322898867887 no 1827 0.460080376454964 2659 8548020 SGTC_3064 1327-0027 10 µM -0.10139565351087 0.455833372222005 no 1828 0.459618193344648 2593 16000455 YPR107C YTH1 SGTC_1946 st076057 65.1 µM -0.102383208227723 0.455418254189046 no 1829 0.45922625576041 2587 953009 SGTC_3132 9126706 49.47 µM -0.10357980112653 0.454915332337325 no 1830 0.458751408897074 2802 850858 SGTC_1029 k015-0030 64.7 µM -0.104060026950891 0.454713516161564 no 1831 0.458560856228711 2707 2208316 SGTC_2259 7964009 200 µM -0.104680130711469 0.454452933211804 no 1832 0.458314814361325 2767 313134 SGTC_2416 tofa 880 nM -0.104686755531763 0.454450149403958 no 1833 0.458312185882195 2634 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3038 9091290 49.47 µM -0.10548177177876 0.454116092857266 no 1834 0.457996766652962 2645 25236843 SGTC_533 1222-0222 6.71 µM -0.105831411991142 0.45396918838296 no 1835 0.457858056785787 2773 3982874 SGTC_1602 st001878 87.6 µM -0.105996771004404 0.453899713501097 no 1836 0.457792457059963 2790 595405 YLR310C CDC25 SGTC_3093 9117344 49.47 µM -0.106508209498021 0.453684843744231 no 1837 0.457589571111433 2745 24824913 SGTC_722 3534-0461 190 µM -0.106513287523003 0.453682710390371 no 1838 0.457587556731143 2643 658262 SGTC_470 aa-861 153 µM -0.107674101893845 0.45319507019359 no 1839 0.457127106873415 2618 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2940 9060638 45.86 µM -0.108180218848796 0.452982480322689 no 1840 0.45692636796529 2676 4027022 SGTC_3079 9117512 49.47 µM -0.109930370584506 0.452247449087436 no 1841 0.456232298130937 2572 7185044 SGTC_1221 2958-7315 257 µM -0.110499567619938 0.452008432041441 no 1842 0.456006596379989 2682 4562705 SGTC_1781 st038725 66.3 µM -0.110913899484149 0.451834456864717 no 1843 0.455842311708243 2594 4270275 YIL048W NEO1 SGTC_381 3461-2219 42.7 µM -0.110942627452924 0.451822394525405 no 1844 0.455830921203433 2649 2883159 SGTC_3287 9117173 37.0625 µM -0.11371505671094 0.45065851400059 no 1845 0.454731838209214 2606 2789709 SGTC_2110 5483698 200 µM -0.113847587252882 0.450602887518628 no 1846 0.454679307313015 2660 2848765 YHR062C RPP1 SGTC_1264 0783-0040 158 µM -0.114842829100946 0.450185189957839 no 1847 0.454284850451808 2597 2855798 SGTC_2698 st077697 67.5 µM -0.116364908127789 0.449546488586667 no 1848 0.453681672837508 2645 3154499 SGTC_1799 st045822 46.1415 µM -0.117010625293612 0.449275569348564 no 1849 0.453425816778636 2616 3674992 SGTC_2212 7123476 200 µM -0.118096841805009 0.448819886149388 no 1850 0.452995462908209 2640 1085715 SGTC_1019 4262-0212 3.4 µM -0.118583477097414 0.448615757617506 no 1851 0.45280267817071 2610 4677213 SGTC_1674 st016616 23.6 µM -0.119328312098348 0.448303348613654 no 1852 0.452507626967887 2596 625830 SGTC_2344 7990960 76.95 µM -0.120128967931446 0.447967562220754 no 1853 0.452190492729228 2652 140813 SGTC_1974 st069448 26.9 µM -0.1203556351208 0.44787250721495 no 1854 0.452100716954061 2696 6323587 YNR016C ACC1 SGTC_3316 9136639 10.545 µM -0.12059786794954 0.447770927921538 no 1855 0.45200477882388 2713 4903665 SGTC_833 3852-0053 558 µM -0.120996755709716 0.447603663524455 no 1856 0.451846802442094 2749 3123681 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.121817643580229 0.447259472447951 no 1857 0.451521720230701 2724 7104 SGTC_1675 st018485 24.5 µM -0.121894711811764 0.447227160450538 no 1858 0.45149120188028 2700 3323024 SGTC_1999 st074831 12.5 µM -0.12281733672818 0.446840363547766 no 1859 0.4511258727365 2659 17112523 SGTC_1383 3049-0032 20.7 µM -0.122921257640403 0.446796799398107 no 1860 0.451084726058917 2745 712864 SGTC_3259 9138485 49.47 µM -0.123288208607082 0.446642976915334 no 1861 0.450939438883054 2736 17646153 SGTC_571 k831-0106 44.2 µM -0.12330193788283 0.446637221884399 no 1862 0.450934003167883 2638 4783639 SGTC_532 1548-0774 215 µM -0.123426226716182 0.446585123065013 no 1863 0.450884794967898 2826 5932993 SGTC_666 0272-0154 136 µM -0.123766986327736 0.446442289755724 no 1864 0.450749885940698 2658 6870312 SGTC_491 tetrandrine 80.3 µM -0.125109516218819 0.445879620705008 no 1865 0.450218424819957 2718 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3095 9117207 49.47 µM -0.125171867131759 0.44585349139069 no 1866 0.450193744413093 2714 17015229 SGTC_2638 epoxomicin 18 µM -0.125226241700148 0.445830704904452 no 1867 0.450172221445679 2732 9915668 A protesome inhibitor. SGTC_1835 st008666 49.2 µM -0.125523058253461 0.445706322589272 no 1868 0.450054735778568 2643 690455 SGTC_3215 9129942 49.47 µM -0.125733052627972 0.445618326726461 no 1869 0.449971618633163 2673 17682944 SGTC_530 4358-1714 28 µM -0.126143556984916 0.44544631707324 no 1870 0.449809144668064 2739 1564641 SGTC_2572 astragaloside iv 100 µM -0.127840645311 0.444735311973357 no 1871 0.449137541821215 2813 45006101 An anti-inflammatory agent. SGTC_1312 1218-2183 165 µM -0.129110672562713 0.444203342785101 no 1872 0.448635038604924 2618 6744073 SGTC_1205 4161-2785 76 µM -0.129671833962953 0.443968324216481 no 1873 0.448413033812132 2790 3498106 SGTC_1516 st013856 110 µM -0.129702628684601 0.443955427727526 no 1874 0.448400851374479 2774 5281404 A mutagen and neurotoxin. SGTC_2667 digitoxin 100 µM -0.130041663502645 0.443813447620567 no 1875 0.44826673191585 2678 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2677 mitomycin C 100 µM -0.130457424728296 0.443639346077015 no 1876 0.448102268178129 2647 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1341 1486-1360 280 µM -0.131164079400467 0.443343456806772 no 1877 0.447822755451413 2615 3976547 SGTC_3024 9090631 49.47 µM -0.131466942161076 0.443216652275537 no 1878 0.447702967950299 2640 25236383 SGTC_812 4251-0442 148 µM -0.132240608670458 0.442892755029114 no 1879 0.447396991038474 2607 5723007 SGTC_1884 5633444 25 µM -0.132260986400056 0.44288422436105 no 1880 0.447388932284521 2777 5724239 SGTC_3119 9125183 49.47 µM -0.132311165482707 0.44286321815447 no 1881 0.447369088121225 2642 22695334 SGTC_2967 9089538 49.85 µM -0.132504801262727 0.442782158928171 no 1882 0.447292512826608 2815 728216 SGTC_2191 5911152 200 µM -0.13307726105602 0.442542531554938 no 1883 0.447066139114428 2658 2875902 SGTC_371 0195-0006 7.36 µM -0.13312764540726 0.442521442048758 no 1884 0.447046215932579 2611 3928593 SGTC_3035 9091303 49.47 µM -0.133497493299698 0.44236663886463 no 1885 0.446899973292556 2636 25237002 SGTC_2413 inermin 26.06 µM -0.133759969422718 0.44225678244398 no 1886 0.446796191218068 2928 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1500 4488-1866 171 µM -0.134478908922963 0.441955901188463 no 1887 0.446511943915329 2786 2900003 SGTC_2956 9076196 2.52 µM -0.135222057527369 0.441644923449306 no 1888 0.446218153938233 2715 16423868 SGTC_2398 5228213 48.84 µM -0.1378076880303 0.440563222779276 no 1889 0.445196204083571 2713 80771 YMR134W ERG29 SGTC_3017 9080681 49.47 µM -0.137839034107538 0.440550111825726 no 1890 0.445183817016395 2724 16451914 SGTC_176 1486-1328 72.834 µM -0.139716367865189 0.439765008970181 no 1891 0.44444204678589 2720 22310231 SGTC_396 dithiazanine 1.25 µM -0.140387873330049 0.439484242056462 no 1892 0.44417676932397 2675 10578 An antihelmenthic. SGTC_328 k915-0120 63.5 µM -0.140463502845339 0.439452622080407 no 1893 0.444146893535551 2778 6624543 SGTC_2458 5808907 16.39 µM -0.140494927929548 0.43943948366724 no 1894 0.444134479835619 2650 2731747 SGTC_433 pimozide 108 µM -0.143430540498435 0.438212438891577 no 1895 0.442975082247981 2645 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1738 st035555 74 µM -0.144646079046483 0.43770453402754 no 1896 0.44249515698188 2757 5331140 SGTC_2529 gangaleoidin 93.61 µM -0.145985175034029 0.437145120320368 no 1897 0.441966545825727 2681 4565183 SGTC_1362 1611-0397 101 µM -0.14614097525998 0.437080042174556 no 1898 0.441905050028264 2678 27816 SGTC_2735 sertaconazole 140 nM -0.147085817687782 0.436685415650425 no 1899 0.441532141984827 2658 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1883 5-benzylidenerhodanine 20 µM -0.147871504528445 0.436357310620069 no 1900 0.441222088518267 2759 1273210 SGTC_2195 6536160 144.242 µM -0.14800510955601 0.436301521135217 no 1901 0.441169367906901 2661 3834386 SGTC_1608 st001473 40.5 µM -0.148029366233412 0.43629139240424 no 1902 0.441159796321535 2658 7292267 SGTC_1965 Pectolinarigenin 58.4 µM -0.148451300171633 0.436115214396752 no 1903 0.440993308424112 2690 5320438 An anti-inflammatory. SGTC_3207 9114163 49.47 µM -0.148752056655966 0.435989641624304 no 1904 0.440874641436253 2881 849233 SGTC_22 0964-0034 14.468 µM -0.149602943553258 0.435634411700464 no 1905 0.440538942851516 2703 138402 SGTC_1335 1486-0900 202 µM -0.14973434615553 0.435579558107033 no 1906 0.440487104667311 2655 X1335 SGTC_1402 3909-7673 35.9 µM -0.151118621003221 0.435001772529161 no 1907 0.439941071876096 2642 5328014 SGTC_1850 st056238 17 µM -0.151643572542788 0.434782698053272 no 1908 0.439734032439497 2639 5393177 SGTC_3315 9136395 68.55 µM -0.151934741192884 0.434661195237585 no 1909 0.439619203430662 2687 16876844 SGTC_2815 7968870 71.43 µM -0.15239383823504 0.434469629517489 no 1910 0.439438158347007 2703 2977326 YHR190W ERG9 SGTC_513 4245-1575 41.7 µM -0.153473403103177 0.434019224192718 no 1911 0.43901248153024 2805 719745 SGTC_178 4092-0806 87.505 µM -0.153977138325821 0.433809090060205 no 1912 0.438813880784781 2667 2169044 SGTC_2877 9040724 71.43 µM -0.154491013215023 0.433594745420624 no 1913 0.438611298284861 2854 6463895 SGTC_2309 7664088 163.95 µM -0.15812852494547 0.432078048671902 no 1914 0.437177761862009 2744 704922 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.158633963336061 0.431867379764198 no 1915 0.436978634366596 2759 279621 SGTC_1940 st075990 51.1 µM -0.158872490000125 0.431767967544047 no 1916 0.436884667590492 2940 1084979 SGTC_339 3091-4833 71.4 µM -0.15932108508704 0.43158101552906 no 1917 0.436707954716478 2694 3240077 SGTC_198 3454-2873 16.191 µM -0.159321648602003 0.431580780693812 no 1918 0.436707732741713 2700 710957 SGTC_1794 st048918 76.9 µM -0.15947905003666 0.43151518727794 no 1919 0.436645731359362 2648 672303 SGTC_1033 k072-0102 21.3 µM -0.159732032164243 0.431409766771206 no 1920 0.436546083422352 2750 5965931 SGTC_3089 9117425 49.47 µM -0.160546460251471 0.431070418616515 no 1921 0.436225313124415 2766 9401657 SGTC_604 1000-0114 314 µM -0.160615217607836 0.431041771780358 no 1922 0.436198234298358 2805 1572745 SGTC_3262 9137218 49.47 µM -0.163220468586413 0.429956597314337 no 1923 0.435172425356439 2642 17650664 SGTC_3298 9116858 71.43 µM -0.163634469883609 0.429784200371955 no 1924 0.435009453700109 2816 2506942 SGTC_5 0352-0601 109.883 µM -0.16366506533976 0.429771460452159 no 1925 0.434997410233176 2728 762456 SGTC_3010 9080089 71.4286 µM -0.163990779616939 0.429635837862577 no 1926 0.434869201172885 2804 17027233 SGTC_1873 rapamycin 2 nM -0.164128661098759 0.429578428561119 no 1927 0.434814929730869 2704 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1527 coumarin 137 µM -0.164362202826088 0.429481192886464 no 1928 0.434723008323104 2933 323 A hepatotoxic, DNA x-linker. SGTC_144 4161-2749 112.381 µM -0.165000738574509 0.429215358807605 no 1929 0.434471700363212 2688 797501 YMR168C CEP3 SGTC_2446 5162541 200 µM -0.166444807552339 0.428614285118372 no 1930 0.433903457189163 2685 1549321 SGTC_1344 1488-0097 29.1 µM -0.166515176709316 0.42858499915125 no 1931 0.433875770307115 2792 747966 SGTC_1497 4476-2978 41.3 µM -0.16705265272758 0.428361327417447 no 1932 0.433664310031263 2780 1528379 SGTC_1118 chelidonine 707.474 nM -0.167074725468878 0.428352142292869 no 1933 0.433655626313502 2713 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_735 3076-0345 636 µM -0.168608170099766 0.427714125629649 no 1934 0.433052426883149 2838 2888990 SGTC_1472 k841-0093 193 µM -0.169097938388878 0.427510388638099 no 1935 0.432859803253406 2808 X1472 SGTC_153 4077-0274 519.67 µM -0.169294326345895 0.427428699327452 no 1936 0.432782569245648 2873 3121976 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.170054400535621 0.427112569087918 no 1937 0.432483677098874 2888 688798 SGTC_2742 clothiapine 36.27 µM -0.17013842041946 0.427077626386804 no 1938 0.432450639424589 2725 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1141 3253-0389 52.6 µM -0.170520110405609 0.426918894037917 no 1939 0.432300560074307 2688 5402031 SGTC_36 0335-0881 14.2 µM -0.170878261597087 0.426769961462503 no 1940 0.432159744989363 2698 23828853 SGTC_169 k015-0017 16.025 µM -0.171255950348872 0.426612915753097 no 1941 0.432011257615207 2826 1840002 SGTC_190 3970-0790 3.722 µM -0.172602364720869 0.426053161767205 no 1942 0.431481996509795 2678 2832352 SGTC_3324 9138759 60.749 µM -0.17289197051618 0.425932781411071 no 1943 0.431368171605184 2837 45595710 SGTC_2091 4-phenylthiadiazole 200 µM -0.173303323211131 0.425761806423825 no 1944 0.431206505836559 2735 270010 SGTC_466 geldanamycin 89.2 µM -0.175251489559997 0.424952258989021 no 1945 0.43044101374687 2740 5288382 HSP90 inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.175665988817915 0.424780057311863 no 1946 0.430278178365613 2733 688669 SGTC_2090 5301565 104.445 µM -0.175789328000034 0.424728819425099 no 1947 0.43022972704963 2748 2056344 SGTC_3268 9137683 49.47 µM -0.176341492133248 0.424499453554424 no 1948 0.430012833368442 2692 1953228 SGTC_819 1013-0258 27.7 µM -0.176386993458647 0.424480553699225 no 1949 0.429994961091308 2731 5753198 SGTC_57 miconazole 162.5 nM -0.177209357093357 0.424138999034517 no 1950 0.429671973043988 2678 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1635 st007035 42.4 µM -0.178764085262465 0.423493425155373 no 1951 0.429061473387254 2710 3716403 SGTC_2192 5915882 198.485 µM -0.180525806421986 0.422762149250638 no 1952 0.428369898300815 2725 2876149 SGTC_1127 asiatic acid 681.4 nM -0.1821042303457 0.422107184429174 no 1953 0.427750464454358 2718 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1723 st034307 2.5525 µM -0.182181012209436 0.422075329379462 no 1954 0.427720336846309 2808 867466 SGTC_1905 st060207 84.5 µM -0.182285731648075 0.422031884486854 no 1955 0.427679247793689 2706 1948547 SGTC_217 ketoconazole 989 nM -0.183280870200086 0.421619079354618 no 1956 0.427288821760738 2809 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_9 0092-0002 10.449 µM -0.184512531491394 0.421108278746246 no 1957 0.426805698611827 2765 759368 SGTC_3261 9137475 49.47 µM -0.184647350810076 0.421052373863815 no 1958 0.426752821948711 2700 17027690 SGTC_1194 1488-0194 225 µM -0.185005726622073 0.420903775621324 no 1959 0.426612271958614 2702 1391452 SGTC_3141 9094609 49.47 µM -0.186009640897596 0.420487569036899 no 1960 0.426218600464773 2718 25236309 YDL196W YDL196W SGTC_2953 9074162 66.49 µM -0.187117437676705 0.420028397616364 no 1961 0.425784278167702 2835 16451992 SGTC_718 1130-0073 349 µM -0.189489016142781 0.419045767141758 no 1962 0.424854781501961 2893 6740020 SGTC_234 nsc-17383 10.7 µM -0.189775695634538 0.418927019566573 no 1963 0.424742450926953 2854 408974 SGTC_3214 9129694 49.47 µM -0.191218804910913 0.418329371270036 no 1964 0.424177085629438 2856 17158655 SGTC_1200 1643-0193 18.4 µM -0.191505362588401 0.418210718856116 no 1965 0.424064839777357 2730 5403974 SGTC_313 3474-0040 5.03 µM -0.191780846162514 0.418096658815442 no 1966 0.42395693750534 2735 1043375 YIL048W NEO1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.191953142855759 0.418025325330121 no 1967 0.423889454692199 2754 641818 YHR062C RPP1 SGTC_1941 st076221 61.8 µM -0.19236318146739 0.417855573877402 no 1968 0.423728865354261 2916 2828568 SGTC_759 3486-0358 89.3 µM -0.192659524487206 0.417732900667877 no 1969 0.423612812144953 2789 875103 SGTC_2183 6420625 130.508 µM -0.193267116831194 0.417481408726969 no 1970 0.423374888881158 2744 2897619 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.193664032161733 0.417317137504608 no 1971 0.423219478384618 3031 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3155 9099265 49.47 µM -0.194266224408297 0.417067935954731 no 1972 0.422983715409517 2859 25236499 SGTC_2162 5663267 200 µM -0.194870243318823 0.41681801195386 no 1973 0.422747264986147 2837 6456493 SGTC_3075 9116269 49.47 µM -0.196310621564427 0.416222164641415 no 1974 0.422183524167956 2938 17015205 YNL244C SUI1 SGTC_2829 7992743 58.44 µM -0.19654310296152 0.416126011092353 no 1975 0.422092549606968 2951 16462845 SGTC_2130 NSC 7 2.4545 µM -0.196705039977369 0.416059037435547 no 1976 0.422029182911105 2872 21448 SGTC_2882 9058044 58.44 µM -0.197837014341201 0.415590945431856 no 1977 0.421586292616182 2855 18076804 SGTC_1086 cerivastatin 2.18 µM -0.198325235284979 0.415389094108834 no 1978 0.42139530445395 2745 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_860 0443-0016 25.1 µM -0.198574993320784 0.41528584213318 no 1979 0.421297608237434 2765 5337942 SGTC_3336 9143619 71.43 µM -0.198845636339536 0.415173962742432 no 1980 0.421191748048859 2754 45595730 SGTC_1978 st071761 42 µM -0.200402843493893 0.414530372719779 no 1981 0.420582767905838 2788 5147680 SGTC_2080 5212524 12.4 µM -0.200594526121309 0.414451166565744 no 1982 0.420507819299775 2757 260183 SGTC_608 k048-0125 159 µM -0.200968060182478 0.414296826652409 no 1983 0.420361774402158 2861 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2789 5281112 71.43 µM -0.201032289302396 0.414270289262577 no 1984 0.420336663110279 2823 765948 SGTC_2432 5630864 12.22 µM -0.201420188064209 0.41411003039443 no 1985 0.420185015444232 2909 5714970 SGTC_1631 benzylvanillin 81.9 µM -0.201528601026692 0.414065242555507 no 1986 0.420142633892688 2911 75506 SGTC_2179 6298986 200 µM -0.201539055845376 0.414060923493286 no 1987 0.420138546870984 2894 738374 SGTC_211 3455-0679 143.504 µM -0.202355110398263 0.413723829680506 no 1988 0.419819559556736 2820 748649 SGTC_256 clotrimazole 625 nM -0.202455136903721 0.413682515345554 no 1989 0.419780463846247 2753 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2431 5490079 200 µM -0.20277541826347 0.413550234725158 no 1990 0.419655286081374 2800 5722345 SGTC_1643 st009866 20.2 µM -0.203417779525413 0.41328496024658 no 1991 0.419404252129904 2854 3156273 YOR207C RET1 SGTC_3003 9075612 71.4286 µM -0.204063894236523 0.413018175643571 no 1992 0.419151784423473 2834 6501993 SGTC_2557 derrustone 83.84 µM -0.204173138469589 0.412973072016977 no 1993 0.419109100799722 2877 629853 An antioxidant. SGTC_709 3807-1509 243 µM -0.206114611943305 0.412171688731978 no 1994 0.418350692573357 2740 1886677 YPL242C IQG1 SGTC_356 1634-0012 32.5 µM -0.207411152321519 0.411636718561682 no 1995 0.417844386839697 2818 735457 SGTC_1119 parthenolide 318.541 nM -0.207437030468905 0.41162604255489 no 1996 0.417834282672099 2969 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2229 7354935 190 µM -0.207810577903544 0.411471943183771 no 1997 0.417688436472934 2838 318112 SGTC_2324 6149169 200 µM -0.209134560087765 0.410925871482221 no 1998 0.417171598063535 2849 2888231 SGTC_1038 k292-0204 154 µM -0.209370869930307 0.410828424455144 no 1999 0.41707936561996 2746 4454212 SGTC_1645 Cervolide 78 µM -0.209935719266126 0.410595519993794 no 2000 0.416858921721131 2858 23173 A fragrance. SGTC_2531 methyl deoxycholate 70.07 µM -0.209986357434449 0.410574641884223 no 2001 0.41683916042558 2781 16667744 Haematoxylin. SGTC_668 1682-0499 62.6 µM -0.210009227582639 0.410565212608452 no 2002 0.416830235531872 2824 682214 SGTC_403 arphamenine a 50 µM -0.210681022654837 0.410288257118878 no 2003 0.416568091981757 2776 5487158 An arginine aminopeptidase inhibitor. SGTC_71 0417-1750 47.813 µM -0.212357962540658 0.409597114255891 no 2004 0.415913889425919 2997 6811472 SGTC_767 0929-0023 86 µM -0.212985504066297 0.40933854807374 no 2005 0.415669134682182 2795 1204563 SGTC_1688 st021091 57.6 µM -0.213354423100223 0.4091865606178 no 2006 0.415525263555625 2831 3656366 SGTC_1315 1237-0019 3.69 µM -0.215464863121768 0.408317363513933 no 2007 0.414702451929229 2885 825140 SGTC_1090 efavirenz 20.7 µM -0.216045614170466 0.408078256715473 no 2008 0.414476096045087 2835 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_76 0433-0009 400.328 µM -0.21666329739221 0.407823981766194 no 2009 0.41423537649429 2919 2841569 SGTC_839 0122-0028 230 µM -0.216688960264667 0.407813418249195 no 2010 0.414225376020306 2797 759448 SGTC_1534 6-azauridine 81.6 µM -0.217062626068813 0.40765961511792 no 2011 0.414079769818081 2760 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2717 st081029 62.2815 µM -0.218432282909014 0.407095977840069 no 2012 0.413546157317496 2882 5292846 SGTC_1197 1601-0112 267 µM -0.218448103839841 0.407089468377186 no 2013 0.413539994480598 2790 7350313 SGTC_187 1488-2104 32.728 µM -0.219485668953528 0.406662622198892 no 2014 0.413135871117425 2856 2852859 SGTC_426 0988-0037 14.6 µM -0.220258051645595 0.406344941952748 no 2015 0.41283509392445 2837 5383008 SGTC_1378 2093-0007 380 nM -0.221169167490904 0.405970280150981 no 2016 0.412480357787419 2908 3618014 SGTC_842 0271-0008 11.1 µM -0.221879262836759 0.405678340081655 no 2017 0.41220393702432 2899 1221709 SGTC_2124 5246320 200 µM -0.222395504993571 0.405466131403594 no 2018 0.412003005354501 2894 579342 SGTC_1135 dihydrocapsaicin 536.708 nM -0.222900571315635 0.405258543598878 no 2019 0.411806445864474 2765 107982 A Capsaicinoid. SGTC_1189 1431-2119 7.28 µM -0.223072116559388 0.405188042680063 no 2020 0.411739689672634 2806 3107275 SGTC_1626 st003712 1.76 µM -0.223141773357605 0.405159416309967 no 2021 0.411712583718513 2961 24207035 SGTC_400 oxethazaine 37.5 µM -0.223502303619148 0.405011259807812 no 2022 0.411572295222001 2873 4621 A local anesthetic. SGTC_2621 lithochol-11-enic acid 100 µM -0.223647836846909 0.404951458159503 no 2023 0.411515668953238 2839 6708711 SGTC_773 4358-1457 44.6 µM -0.224223715581251 0.404714843277051 no 2024 0.411291615434644 2959 1186886 SGTC_943 3253-1379 105 µM -0.224722395263249 0.404509975792471 no 2025 0.411097620635448 2969 668464 SGTC_1484 3473-2379 286 µM -0.224808944369356 0.40447442237083 no 2026 0.411063953787361 2797 671917 SGTC_2766 oltipraz 83.91 µM -0.224837381703428 0.404462740798661 no 2027 0.411052892055172 2951 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1810 st050138 53 µM -0.225138634098902 0.404338996680816 no 2028 0.410935713357762 2862 3444541 SGTC_1420 4'-methoxyflavone 42 µM -0.225140831482757 0.404338094106282 no 2029 0.410934858666512 2839 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2610 ononetin 44.17 µM -0.225239658758911 0.404297501368838 no 2030 0.410896419389172 2866 259632 SGTC_97 0535-0701 19.132 µM -0.226270259369221 0.403874249545726 no 2031 0.410495614077601 2820 2832013 YGL099W LSG1 SGTC_1933 st074711 15.9 µM -0.226366251983684 0.403834832575984 no 2032 0.41045828686034 2752 17250958 SGTC_523 1934-0222 13.7 µM -0.226478665703828 0.403788673930752 no 2033 0.410414575243572 2812 1361595 SGTC_1035 k081-0041 55.2 µM -0.227063944196485 0.40354837206027 no 2034 0.41018701008 2852 731709 SGTC_1931 st074438 57.1 µM -0.228790933145062 0.402839522703928 no 2035 0.409515707100556 2750 2787313 SGTC_2567 aureobasidin a 60 nM -0.22884465099082 0.402817479111888 no 2036 0.40949483052079 3070 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2002 4023503 131 µM -0.229086939520687 0.402718057715445 no 2037 0.409400672157092 2869 4736863 YCR052W RSC6 SGTC_1636 st007707 68.9 µM -0.229322316630963 0.402621478395441 no 2038 0.409309204719432 2975 403051 SGTC_112 phenothiazine 287.218 µM -0.23361292019349 0.400862016306246 no 2039 0.407642748203689 2827 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2937 9044753 11.33 µM -0.235035772570405 0.400278984339407 no 2040 0.407090484150361 2798 6465530 YGL099W LSG1 SGTC_699 0375-0592 111 µM -0.235707656869206 0.4000037482932 no 2041 0.406829763982522 2897 762578 SGTC_2451 5856223 45.7 µM -0.235922780077511 0.399915633995796 no 2042 0.406746295593782 2860 2179896 SGTC_60 0986-0278 202 µM -0.236475833513855 0.399689127142476 no 2043 0.406531728812349 2824 3110598 SGTC_631 k072-0230 41.5 µM -0.23668949530097 0.399601629517043 no 2044 0.406448842485155 2930 5773147 SGTC_1462 k081-0014 26.5 µM -0.236825453362385 0.399545955327862 no 2045 0.406396102131766 2848 3270634 SGTC_2576 guaiol 23.12 µM -0.23761017562924 0.399224655186863 no 2046 0.406091728757738 2965 227829 SGTC_3137 9097352 49.47 µM -0.238055678677978 0.399042276816746 no 2047 0.405918954944925 3133 44120435 SGTC_3223 9129970 49.47 µM -0.238269610919572 0.398954705866062 no 2048 0.405835994819223 2813 17248386 SGTC_557 1315-0110 16.2 µM -0.238593747990068 0.398822033400043 no 2049 0.405710306760457 2829 6833801 SGTC_2896 9052656 71.43 µM -0.239378970307062 0.398500682731492 no 2050 0.405405867654508 2930 6469436 SGTC_3302 9125395 16.351 µM -0.239889221711778 0.398291900232218 no 2051 0.405208068378043 2873 17599668 SGTC_692 k241-0027 77.8 µM -0.241520987556318 0.397624416922501 no 2052 0.404575676073757 2997 3600480 SGTC_2861 9024595 19.48 µM -0.241571707738399 0.397603674328287 no 2053 0.404556023406886 2876 16482810 SGTC_1375 2910-0797 186 µM -0.242694478014837 0.397144578918435 no 2054 0.404121042746403 2905 742508 SGTC_1623 st003709 20.3 µM -0.243208172131514 0.396934579313216 no 2055 0.403922068228092 2823 16192618 SGTC_2294 7971431 200 µM -0.243771735307492 0.396704227472331 no 2056 0.40370380600104 2975 5741572 SGTC_344 k064-0035 6.43 µM -0.244447829116421 0.396427927217981 no 2057 0.403442001382967 2836 5088750 SGTC_520 3584-0023 682 µM -0.245156152865284 0.396138511291755 no 2058 0.403167762736086 2893 1340790 SGTC_500 h-89 112 µM -0.246345226537584 0.395652793208481 no 2059 0.402707501346175 3032 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2488 5268135 45.7 µM -0.246378327191261 0.395639274421143 no 2060 0.402694690816867 2975 1270356 YLR208W SEC13 SGTC_741 4582-0002 126 µM -0.246873403615448 0.395437093016018 no 2061 0.402503100094706 2828 2912688 SGTC_298 1391-0729 10 µM -0.248936994829085 0.394594658586873 no 2062 0.401704759067984 2853 3237558 SGTC_2965 9082772 38.63 µM -0.249441502119338 0.394388774809502 no 2063 0.401509642706488 3016 16459634 SGTC_956 1185-0240 191 µM -0.249788961217618 0.394246997792764 no 2064 0.401375278437712 2862 1416193 SGTC_230 MPP+ 141.667 µM -0.250939597320378 0.393777592998535 no 2065 0.400930404711671 2883 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1039 k821-0043 94 µM -0.2512255324961 0.393660968958857 no 2066 0.40081987267946 3012 15992768 SGTC_3113 9123498 49.47 µM -0.25139673634807 0.393591144812143 no 2067 0.400753695360801 2818 8897275 SGTC_2201 6605497 169.863 µM -0.251474325190239 0.393559501938661 no 2068 0.400723705025178 2885 670741 SGTC_707 0865-0008 204 µM -0.252353228681696 0.393201109940882 no 2069 0.400384024257064 2874 723043 SGTC_1700 st030840 7.9285 µM -0.25241675987909 0.393175207217945 no 2070 0.40035947348121 2954 5499307 SGTC_2219 9098279 200 µM -0.253183685594719 0.39286255622663 no 2071 0.400063136453516 2899 902349 SGTC_3047 9092122 49.47 µM -0.253395074996763 0.392776391695246 no 2072 0.39998146654233 2912 17173831 SGTC_221 trifluoperazine 10.304 µM -0.254163582849538 0.392463184158881 no 2073 0.399684591816544 2873 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2146 5545642 200 µM -0.254466523462372 0.392339738985275 no 2074 0.399567581725521 2869 825326 SGTC_152 4469-0003 551.229 µM -0.254543841393756 0.392308234460821 no 2075 0.399537719302865 2852 697280 SGTC_2630 antimycin a 100 µM -0.254763878363928 0.392218580466143 no 2076 0.399452737873955 2798 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_325 2810-4341 181 µM -0.255507156419837 0.391915774384142 no 2077 0.399165708491639 2966 774970 SGTC_2794 7785382 27.27 µM -0.25558249979862 0.391885083689608 no 2078 0.399136616412709 2883 2205081 SGTC_47 0149-0135 24.25 µM -0.255758638397148 0.391813337263705 no 2079 0.39906860680926 2836 5239155 SGTC_3243 9134147 49.47 µM -0.256207984074386 0.391630322238151 no 2080 0.398895121971499 2917 24282180 SGTC_1874 staurosporine 7.6 µM -0.257368425777187 0.391157794323537 no 2081 0.398447187338542 2981 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1483 3453-0561 55.9 µM -0.258631844396955 0.390643517196569 no 2082 0.397959655359636 2952 4546991 SGTC_137 0438-0332 85.389 µM -0.259063472914254 0.390467865709378 no 2083 0.39779313364669 2887 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1079 idarubicin 2.36 µM -0.261848152993634 0.389335177240506 no 2084 0.39671925656078 2937 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1659 st012954 42.1 µM -0.262084698216102 0.389239003949587 no 2085 0.396628071811006 3003 24207262 SGTC_1467 k284-1082 293 µM -0.262315093542926 0.389145337572617 no 2086 0.396539263190969 2973 3334705 SGTC_1553 gossypol 38.6 µM -0.2625055701087 0.38906790488578 no 2087 0.396465845784934 2842 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2158 5657123 3.6195 µM -0.262543513647209 0.389052480574099 no 2088 0.396451221242219 2833 2858827 SGTC_556 4058-0063 51.5 µM -0.262795193023571 0.38895017558866 no 2089 0.396354220383508 2911 6615692 SGTC_2272 7805186 180 µM -0.264468014978352 0.388270387265746 no 2090 0.395709653998389 3007 2956062 YPR165W RHO1 SGTC_669 0108-0021 26.2 µM -0.266303486388863 0.387524896426829 no 2091 0.395002744135825 2996 17201 SGTC_2029 5175081 200 µM -0.266966396051349 0.387255752308115 no 2092 0.39474751720376 2863 1380876 SGTC_2073 5212005 126 µM -0.270564869931986 0.385795705277706 no 2093 0.393362859010897 2827 691789 SGTC_1783 st039459 87.517 µM -0.270874239881607 0.385670256490026 no 2094 0.39324387909164 3105 729761 SGTC_3323 9138564 53.9225 µM -0.271509346630851 0.385412759680614 no 2095 0.392999656016338 3047 43912313 YNL103W MET4 SGTC_1857 st056007 79.3 µM -0.272529595095968 0.384999217313153 no 2096 0.392607419270782 2953 619834 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.272532672697337 0.384997970051338 no 2097 0.392606236245005 2878 66535 A nucleotide analog. SGTC_1848 st056003 16.4 µM -0.27336555121664 0.384660472524156 no 2098 0.392286115380024 2914 146492 SGTC_3230 9131665 49.47 µM -0.273953688547257 0.384422201207052 no 2099 0.392060105856971 2875 15943720 SGTC_316 k060-0003 58.6 µM -0.274680148467298 0.384127951717746 no 2100 0.391780991976158 3039 6152314 SGTC_1703 st026983 48.3 µM -0.275507909270142 0.383792752134749 no 2101 0.391463025071093 3044 1104023 SGTC_1895 st058434 18.3 µM -0.275759000717129 0.383691090479442 no 2102 0.391366587895422 3068 5393175 SGTC_959 1222-0044 107 µM -0.275852825879527 0.383653104695176 no 2103 0.391330553997966 3025 6083612 SGTC_2233 sulbentine 40.3845 µM -0.276854871021204 0.383247489397911 no 2104 0.39094577311559 2924 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3154 9100113 49.47 µM -0.278439655034946 0.38260625007983 no 2105 0.390337441120816 2916 25237525 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.279595264639321 0.382138867111704 no 2106 0.389894020268744 3022 5024745 SGTC_3062 9077494 49.47 µM -0.280764720035536 0.381666059038593 no 2107 0.38944543245962 3033 16459633 SGTC_2020 4017018 200 µM -0.281392711018009 0.381412236547186 no 2108 0.389204604062013 3006 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_89 0302-0250 142.109 µM -0.281793125391062 0.381250422983526 no 2109 0.389051071278378 2877 4203518 YLR208W SEC13 SGTC_779 1360-0071 233 µM -0.283178148585725 0.380690874205431 no 2110 0.388520138992501 3094 7566 SGTC_432 NS 1619 61.3 µM -0.283542041357034 0.380543903016991 no 2111 0.388380679493421 3082 4552 A K+/calcium channel activator. SGTC_3190 9110366 49.47 µM -0.283613481915289 0.380515051201002 no 2112 0.388353302060883 3010 17123768 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.284928043942433 0.379984274054787 no 2113 0.387849635080126 2954 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1805 st050013 60.3 µM -0.285199012426529 0.379874893903173 no 2114 0.387745838463435 2962 4037144 SGTC_2388 9080168 200 µM -0.285533417457551 0.379739919965621 no 2115 0.387617753035093 2899 15943073 SGTC_2551 apiole 73.87 µM -0.285846280450408 0.37961365417925 no 2116 0.387497929815043 2872 10659 A possible DNA adduct former. SGTC_2666 tannic acid 100 µM -0.288442052321757 0.37856654432906 no 2117 0.386504190891261 2998 16134267 A thiamine antagonist. SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.288509499396404 0.378539348658983 no 2118 0.386478380025908 2901 23665772 A membrane-active detergent. SGTC_3281 9140613 49.47 µM -0.290631485376784 0.3776840399721 no 2119 0.385666588575878 2955 16013766 SGTC_477 mead ethanolamide 10 µM -0.292897246104397 0.376771441724813 no 2120 0.384800346942384 2888 16061185 SGTC_2996 9066192 71.4286 µM -0.293128214548738 0.376678451314438 no 2121 0.384712075703747 2961 6472854 SGTC_1683 st010134 710 nM -0.293469850534746 0.376540918066844 no 2122 0.384581520637293 2907 3818134 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.293589130488565 0.376492902929355 no 2123 0.384535941277923 2983 688761 SGTC_1247 0448-0043 5.84 µM -0.294134378579229 0.376273442260494 no 2124 0.384327610937832 3044 3089013 YGL099W LSG1 SGTC_1474 0330-0125 5.35 µM -0.294215336351637 0.376240860416179 no 2125 0.384296681149798 2965 X1474 SGTC_570 0987-0065 62.6 µM -0.294527176342071 0.376115367157656 no 2126 0.384177550063793 2857 3104428 SGTC_2198 6589944 200 µM -0.294831214594879 0.375993026150032 no 2127 0.384061409980834 2951 5290268 SGTC_750 4073-0104 132 µM -0.294833209285867 0.375992223553661 no 2128 0.384060648059835 2994 22330957 SGTC_2137 5261020 140 µM -0.295193625491826 0.375847213037276 no 2129 0.383922985634523 2914 763655 SGTC_100 0086-0128 49.5915 µM -0.297039128849636 0.375104964963608 no 2130 0.383218318018615 2967 93297 SGTC_2973 9094665 17.96 µM -0.297582539611112 0.374886497067959 no 2131 0.383010901261165 3143 25237061 YIL048W NEO1 SGTC_2462 5162487 171.77 µM -0.297789635709471 0.374803248605771 no 2132 0.382931862696743 2894 2259986 SGTC_3196 9111891 49.47 µM -0.298256006724464 0.374615798212935 no 2133 0.382753889289002 2893 18891510 SGTC_698 k064-0052 127 µM -0.299598644043002 0.374076312107658 no 2134 0.382241659294439 2959 5088751 SGTC_3045 9092950 49.47 µM -0.302437988324356 0.372936246149501 no 2135 0.381159099640815 3081 44120432 SGTC_447 ml7 120 µM -0.303009160758104 0.372707040506157 no 2136 0.380941440160912 3007 4216 Selective myosin light chain kinase inhibitor. SGTC_3072 9116419 49.47 µM -0.304369858083922 0.3721611883048 no 2137 0.380423064432062 3002 17170162 SGTC_1618 st003135 44.5 µM -0.304640608895668 0.37205260552723 no 2138 0.380319943888536 2975 1270615 SGTC_2714 st079313 56.9 µM -0.304714906398854 0.372022810795903 no 2139 0.380291647772711 2936 2939799 SGTC_2048 5246248 200 µM -0.305555585348213 0.371685735756433 no 2140 0.379971520860009 3063 677046 SGTC_2539 epi(13)torulosol 80 µM -0.305840631121984 0.371571467335229 no 2141 0.379862995315978 3054 6708597 SGTC_2935 9038016 29.96 µM -0.305942178224365 0.371530762125585 no 2142 0.379824335549073 3100 6463195 SGTC_911 3456-4043 236 µM -0.306826065506788 0.37117651615774 no 2143 0.379487883591422 3034 914281 SGTC_961 1252-1571 372 µM -0.307627068348415 0.370855583007418 no 2144 0.379183060416072 3128 6813498 SGTC_427 1354-0053 47.3 µM -0.307670135161875 0.370838330220253 no 2145 0.379166673383146 3163 6813657 SGTC_2092 5303694 80.6725 µM -0.307737261168031 0.37081143971445 no 2146 0.379141132198699 2968 1963699 SGTC_3049 9092223 49.47 µM -0.308299132779735 0.37058638014514 no 2147 0.378927362935299 3044 8623917 SGTC_582 0987-0078 156 µM -0.308669543778139 0.370438034983235 no 2148 0.378786456884235 3063 1625765 SGTC_202 3594-0513 34.79 µM -0.309903736241447 0.369943894848723 no 2149 0.378317080742073 2954 708429 SGTC_2951 9072950 58.06 µM -0.311230760875921 0.369412826475769 no 2150 0.377812599836553 2963 16488155 SGTC_1153 4055-0057 267 µM -0.311292579147456 0.369388093188374 no 2151 0.377789104110613 2942 882706 SGTC_1984 st072354 53.1 µM -0.311394563773414 0.369347290656083 no 2152 0.37775034305068 2927 5762938 SGTC_1154 4088-0362 150 µM -0.311924011678088 0.369135490083971 no 2153 0.377549136806034 2928 6618304 SGTC_2107 5363541 170.161 µM -0.313859698144359 0.368361475763332 no 2154 0.376813800484403 3053 244052 SGTC_2176 5809774 33.9695 µM -0.314619216324639 0.368057916286227 no 2155 0.376525393539532 3079 2870539 SGTC_2216 7189485 200 µM -0.314918942022551 0.367938146449311 no 2156 0.376411599585426 3065 731273 SGTC_2712 st079126 47.7 µM -0.314936412799804 0.36793116555475 no 2157 0.376404966955742 2942 3152970 SGTC_1263 0774-1208 64.8 µM -0.315483008107125 0.36771278150279 no 2158 0.376197475209228 3139 906585 SGTC_449 xestospongin c 11.1929 µM -0.316830149845392 0.367174733695175 no 2159 0.375686242797877 3069 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2361 9034121 116 µM -0.318802189901817 0.366387572224083 no 2160 0.374938258781137 2989 6496917 SGTC_1108 betulinic acid 729.144 nM -0.319157828684271 0.366245674791929 no 2161 0.374803416892252 3018 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3001 9076041 71.4286 µM -0.319963649329605 0.365924225576311 no 2162 0.374497943370537 2946 16004211 SGTC_1369 1866-0067 208 µM -0.321244120094425 0.365413627727657 no 2163 0.374012699760113 3120 3531355 SGTC_1922 5578187 25 µM -0.321548100442306 0.365292448145802 no 2164 0.373897533504229 3168 1350412 SGTC_1044 1222-0021 1.78 µM -0.321931045985147 0.365139808798957 no 2165 0.373752466450054 3067 4306703 SGTC_3156 9099931 49.47 µM -0.322557348688693 0.364890215085794 no 2166 0.373515249624889 2936 18111053 SGTC_2006 4011487 200 µM -0.323900135150449 0.364355281816648 no 2167 0.373006820831676 3134 45595294 SGTC_2299 7976368 114.88 µM -0.32497360419966 0.363927827908855 no 2168 0.372600524583888 3128 2979718 SGTC_977 1348-1378 135 µM -0.325047435251782 0.363898434700163 no 2169 0.372572585545081 2952 X977 SGTC_1862 st057513 3.81 µM -0.326355177157894 0.363377936610959 no 2170 0.372077823007342 2969 5393163 SGTC_2961 9083290 32.55 µM -0.326830292303539 0.363188897067993 no 2171 0.371898123286963 3052 17741490 SGTC_3125 9127534 49.47 µM -0.328621327180065 0.362476577270201 no 2172 0.371220962922907 3051 1639235 SGTC_2241 6772625 37.8075 µM -0.329766690132999 0.362021299554468 no 2173 0.370788129077455 2951 2285411 SGTC_1938 st074717 56.4 µM -0.330040647855187 0.361912431230051 no 2174 0.370684624375157 2921 17250979 SGTC_3258 9138477 49.47 µM -0.330188856479308 0.361853539118163 no 2175 0.370628633177438 3022 4970355 SGTC_1177 0983-0204 23.6 µM -0.33035225642453 0.361788614381252 no 2176 0.370566906081374 3135 766818 SGTC_2984 9022109 38.96 µM -0.333552317974858 0.360517917558217 no 2177 0.369358702067707 3110 6459207 SGTC_2671 danthron 100 µM -0.333818831912838 0.360412158064877 no 2178 0.369258135992616 3056 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_794 k038-0031 316 µM -0.335050096088953 0.359923699938727 no 2179 0.368793648369937 3029 6624242 SGTC_985 1493-0307 8.71 µM -0.335284723947947 0.359830646003356 no 2180 0.368705158016213 3143 3278274 SGTC_942 3253-1115 227 µM -0.335439000892299 0.359769463947986 no 2181 0.36864697595947 3188 46497897 SGTC_680 0417-1641 114 µM -0.336001990177752 0.359546228146579 no 2182 0.36843468284688 2967 2835990 SGTC_514 4466-0038 2.65 nM -0.336020631038382 0.359538837515256 no 2183 0.368427654400761 3025 5722064 SGTC_2382 9035899 200 µM -0.336231634382235 0.359455183672368 no 2184 0.368348099683082 3012 6462679 SGTC_2702 st077768 96.8 µM -0.336536849297119 0.359334190870896 no 2185 0.368233034307322 3075 6484119 SGTC_1604 st002052 72.4 µM -0.336780625846318 0.359237563496984 no 2186 0.368141139554094 3125 6254834 YHR062C RPP1 SGTC_1182 1222-0449 220 µM -0.337925521051836 0.358783874093084 no 2187 0.367709657353955 3068 658318 SGTC_1130 3454-2858 15.9 µM -0.339702063550257 0.358080275320956 no 2188 0.367040453789734 3065 715628 YIL048W NEO1 SGTC_507 nimesulide 162 µM -0.340147427231233 0.357903964685949 no 2189 0.366872753524197 3197 4495 A COX2 inhibitor. SGTC_2476 5806916 10.51 µM -0.340806612522418 0.35764306195741 no 2190 0.366624586050486 2983 2870194 SGTC_504 lovastatin 124 µM -0.341619217708896 0.357321527821661 no 2191 0.366318736388089 3043 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1621 st003705 32.4 µM -0.343197082945236 0.356697482632925 no 2192 0.365725099519123 3163 24207032 SGTC_408 cantharidin 100 µM -0.343326411924221 0.356646350040565 no 2193 0.365676456586157 3039 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1102 cgs 12066b 26.1 µM -0.343558474892571 0.356554606133496 no 2194 0.3655891789848 3048 6438352 A 5-HT1B full agonist. SGTC_151 3013-0144 2.285 µM -0.343566162736158 0.356551566958998 no 2195 0.365586287748316 3191 906558 YHR107C CDC12 SGTC_618 k072-0232 33.2 µM -0.344503047082117 0.356181264111662 no 2196 0.365234002442796 3087 5872756 YGL099W LSG1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.344854876118198 0.356042238946398 no 2197 0.36510173776714 3041 688664 SGTC_919 tnp00227 403.569 nM -0.346014114977779 0.355584301469803 no 2198 0.364666053494665 3017 1269246 A methoxyflavone. YNL221C POP1 SGTC_56 0957-0365 83.25 µM -0.34613209190236 0.355537708375947 no 2199 0.364621723247657 3135 6752360 SGTC_1761 st044296 37 µM -0.347333393133294 0.355063396735997 no 2200 0.364170433213565 2986 1826700 SGTC_949 1165-0505 146 µM -0.348065143082799 0.354774588735856 no 2201 0.363895630643382 3018 6244267 SGTC_2943 9068529 45.32 µM -0.348619899776734 0.35455569226011 no 2202 0.363687343041141 3006 3270634 SGTC_1359 1582-0056 520 nM -0.348832886045721 0.354471664670313 no 2203 0.363607386430915 3114 3661189 SGTC_952 1185-0122 232 µM -0.349010049049813 0.354401775512134 no 2204 0.363540882663013 2980 678600 SGTC_2516 gossypol 71.55 µM -0.349196491371177 0.35432823104394 no 2205 0.363470900048905 3163 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2863 9028737 58.44 µM -0.350639864054117 0.353759058916431 no 2206 0.362929272914911 3090 6460917 SGTC_261 5-fluorouridine 15.376 µM -0.350864436706261 0.353670531437665 no 2207 0.362845026400041 3235 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3130 9127414 49.47 µM -0.351946117483824 0.35324423927498 no 2208 0.362439336134548 3083 1494646 SGTC_902 1120-0002 2.07 µM -0.353738071530462 0.35253843252373 no 2209 0.361767594007464 3019 3280475 SGTC_465 cgp-37157 41 µM -0.354274369475508 0.352327296455102 no 2210 0.361566636972565 3079 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_332 4112-0506 40.9 µM -0.354990116194528 0.352045583781253 no 2211 0.361298497894395 3037 2790355 SGTC_2990 9074105 71.4286 µM -0.355754536139368 0.351744803335997 no 2212 0.361012199671599 3105 6502001 SGTC_2081 5214970 32.255 µM -0.355922948920293 0.351678549513841 no 2213 0.360949134487762 3146 2063512 SGTC_269 exalamide 29 µM -0.356393937964185 0.351493285689472 no 2214 0.360772784273321 3043 3316 A derivative of salicylamide. SGTC_541 4513-1321 94 µM -0.35696309500962 0.351269454490377 no 2215 0.360559716974753 3039 747515 SGTC_2588 indole-3-carbinol 100 µM -0.358837932125617 0.350532506367367 no 2216 0.359858167086571 3156 3712 Induces cell cycle arrest. SGTC_1073 triclabendazole 3.09 µM -0.359377572906857 0.350320492143133 no 2217 0.359656324934701 3126 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1615 st002656 86.5 µM -0.359443758171454 0.350294492466514 no 2218 0.359631572315681 3073 1584458 SGTC_1004 4084-0029 199 µM -0.360966732999813 0.349696413544759 no 2219 0.359062158010202 3175 716894 YLR208W SEC13 SGTC_1609 st001574 46.4 µM -0.361592364397216 0.349450833288092 no 2220 0.358828335722609 3034 3960012 SGTC_2520 obtusaquinone 4.71 µM -0.363115378859441 0.348853265128591 no 2221 0.35825934844912 3209 5967872 SGTC_3253 9135987 49.47 µM -0.363608702052511 0.348659785693948 no 2222 0.358075113839987 3145 4182430 SGTC_2070 5230947 200 µM -0.363964862119954 0.348520125563375 no 2223 0.35794212418964 3147 2835538 SGTC_2384 9036245 200 µM -0.366675204587282 0.347457999734013 no 2224 0.356930652046809 3087 6462766 SGTC_879 0831-1030 162 µM -0.367841636607613 0.347001267504972 no 2225 0.356495660387391 3057 1549252 SGTC_2890 9046729 58.44 µM -0.370486308634178 0.345966534249456 no 2226 0.355510088040919 3052 903329 SGTC_1789 tunicamycin 25 nM -0.371216549476432 0.345681028182538 no 2227 0.35523812383628 3168 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.371624472952139 0.345521578403886 no 2228 0.355086232638568 2975 4000243 SGTC_3091 9116372 49.47 µM -0.372039127982911 0.345359525471803 no 2229 0.35493185852889 3216 17169793 SGTC_1710 st031758 61.5 µM -0.372404715050076 0.345216672490027 no 2230 0.354795771942572 3224 5394341 SGTC_2490 carminic acid 95.39 µM -0.37348937113538 0.344792973442874 no 2231 0.354392127289311 3045 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1948 st076329 66.6 µM -0.37431843855885 0.344469246130836 no 2232 0.354083707792154 3007 24208413 SGTC_1084 voriconazole 435 nM -0.37436902096995 0.344449498818104 no 2233 0.35406489383941 3180 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1552 6-methylflavone 10.6 µM -0.375342584060803 0.344069503620414 no 2234 0.353702849884268 3151 689013 SGTC_346 4513-0042 7.16 µM -0.375533701068274 0.343994926469288 no 2235 0.35363179373416 3018 2827372 SGTC_2697 mebhydrolin 72.4 µM -0.37560733301392 0.343966195633886 no 2236 0.353604419181806 3240 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3342 9147791 14.508 µM -0.375913452468446 0.343846758936779 no 2237 0.353490619590869 3057 1838168 SGTC_2174 5790901 200 µM -0.376512279497522 0.343613163433842 no 2238 0.353268044132251 3155 786020 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.376754463371056 0.343518707255301 no 2239 0.353178042089968 3132 6708739 YPR165W RHO1 SGTC_3085 9117376 49.47 µM -0.377465517807472 0.343241439382772 no 2240 0.352913842598769 3156 16480349 SGTC_640 3381-0960 37.1 µM -0.378046425193147 0.343014983527827 no 2241 0.352698053182631 3140 1745025 SGTC_1662 st014054 52 µM -0.378181947603968 0.342962160763809 no 2242 0.35264771754553 3099 2838777 SGTC_878 0828-0289 13.7 µM -0.378703833368725 0.342758773277254 no 2243 0.352453903209729 3085 745350 YLR208W SEC13 SGTC_2102 5377816 72.7585 µM -0.37886578057434 0.342695669042645 no 2244 0.352393768158196 3247 1379702 SGTC_1274 0865-0114 173 µM -0.379191053206597 0.342568936799823 no 2245 0.35227299743581 3114 870624 SGTC_2798 7813637 45.45 µM -0.381552886651673 0.341649254976099 no 2246 0.351396517923065 3201 956368 SGTC_1400 3771-8998 51.5 µM -0.383502404098665 0.34089083343278 no 2247 0.350673644026718 3068 670767 SGTC_2059 5238311 157 µM -0.383672470421766 0.340824702893775 no 2248 0.350610609646101 3029 703021 SGTC_2993 9054257 71.4286 µM -0.384193172813364 0.340622257426849 no 2249 0.350417639034732 3053 6470217 YGL055W OLE1 SGTC_3121 9125696 49.47 µM -0.384240276010717 0.34060394629471 no 2250 0.350400184646283 3121 1235365 SGTC_1285 0929-0069 65.5 µM -0.384737626166482 0.340410626843528 no 2251 0.350215907676194 3106 1206237 SGTC_2623 humulene 100 µM -0.385987451867043 0.33992500615111 no 2252 0.349752981011867 3147 6187145 An anti-inflammatory. SGTC_1134 3477-0009 42.5 µM -0.386515287883855 0.339719994773235 no 2253 0.349557541279452 3301 3973534 SGTC_1226 3909-7979 35.4 µM -0.387859360820065 0.339198171341658 no 2254 0.34906005688988 3198 6615510 SGTC_88 0180-0332 8.668 µM -0.389856116253358 0.33842351956979 no 2255 0.348321472760878 3072 3101745 SGTC_367 0335-0881 7.1 µM -0.390183032107558 0.338296755851216 no 2256 0.348200603842393 3252 23828853 SGTC_233 rapamycin 362 pM -0.39115666725397 0.337919331191192 no 2257 0.347840718096679 3155 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2939 9044578 71.43 µM -0.393522853123446 0.337002770967575 no 2258 0.346966674177047 3049 2653634 SGTC_1648 st011736 69.8 µM -0.394373130657606 0.336673645315578 no 2259 0.346652789157784 3237 2855514 SGTC_1163 k060-0048 49.9 µM -0.395643564028374 0.336182118710812 no 2260 0.346183997252667 3109 6809982 SGTC_186 3455-3465 67.277 µM -0.39789707968663 0.335310929789201 no 2261 0.345353026386997 3060 755278 SGTC_2779 methotrexate 400 µM -0.398960441595384 0.334900150628636 no 2262 0.344961176247814 3205 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2269 7935389 174.42 µM -0.399500615911765 0.334691555637343 no 2263 0.344762184999664 3092 97605 SGTC_3325 9138760 55.175 µM -0.402834125116699 0.333405410553642 no 2264 0.343535127516556 3114 43844959 SGTC_1356 1502-0781 85.8 µM -0.40324521162937 0.333246939034144 no 2265 0.343383921287672 3101 567702 SGTC_2648 atorvastatin 78.68 µM -0.405894334644463 0.332226432104997 no 2266 0.342410120455719 3215 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2513 baicalein 25.65 µM -0.406934436602686 0.331826098746193 no 2267 0.342028071358604 3153 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_898 1000-0849 28.3 µM -0.40812635042666 0.331367569302053 no 2268 0.341590457702998 3204 6751807 SGTC_117 lucigenin 22.078 µM -0.408510565024641 0.331219815701552 no 2269 0.341449437843832 3196 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1819 st053448 58.6 µM -0.408662945230861 0.331161223630704 no 2270 0.34139351524046 3112 2857616 SGTC_2033 5192550 145 µM -0.410112306522072 0.330604133137947 no 2271 0.340861782747883 3142 182073 SGTC_574 1315-0397 40 µM -0.410655681056947 0.33039537305883 no 2272 0.340662514324171 3148 6794277 SGTC_188 3229-0966 278.469 µM -0.411352980361554 0.330127553650526 no 2273 0.340406863151894 3253 5722370 SGTC_1098 clofazimine 15.1 µM -0.412379665492896 0.329733381824666 no 2274 0.340030582579402 3238 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3028 9087778 49.47 µM -0.41447712942002 0.328928697376739 no 2275 0.339262356522264 3131 17217395 SGTC_2540 epiandrosterone 100 µM -0.4146103519446 0.328877613756931 no 2276 0.33921358439159 3146 441302 A steroid. SGTC_1842 st055362 61.2 µM -0.415319443747031 0.32860576927513 no 2277 0.338954034611254 3122 676032 SGTC_1379 2144-0755 36.5 µM -0.415535862534112 0.328522818873114 no 2278 0.338874833782934 3310 5392327 SGTC_1826 st055655 41.6 µM -0.417132866672558 0.327910970205995 no 2279 0.338290612998471 3205 676168 SGTC_2015 5119600 184 µM -0.417488266670725 0.327774871106483 no 2280 0.338160652399655 3284 2828786 SGTC_1425 4048-4433 7.33 µM -0.417547395400561 0.327752230199542 no 2281 0.338139032420981 3236 23734946 SGTC_2927 9011802 47.9 µM -0.41761563382858 0.327726101896682 no 2282 0.338114082212632 3229 43912568 SGTC_51 1013-0126 23.419 µM -0.417700299372289 0.327693684869735 no 2283 0.338083126700136 3397 1627850 SGTC_947 3447-0010 211 µM -0.418819355287646 0.32726533909007 no 2284 0.337674079129759 3211 748350 SGTC_2109 5483026 200 µM -0.419405768485917 0.327040965977048 no 2285 0.33745980451416 3182 759335 SGTC_1911 st060208 74.3 µM -0.420628016806939 0.326573510933581 no 2286 0.337013366016219 3217 688783 SGTC_255 tunicamycin 200.472 nM -0.421058341799043 0.326408995709719 no 2287 0.336856240070079 3194 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_422 cantharidin 155 µM -0.422037722242095 0.326034699962892 no 2288 0.336498741903719 3091 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_224 benfluorex 43.875 µM -0.423803866697843 0.325360164917247 no 2289 0.335854428965517 3260 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1906 st060206 94.7 µM -0.42429741479563 0.325171768579208 no 2290 0.335674462181211 3265 5133468 SGTC_3166 9102297 49.47 µM -0.424559608295066 0.325071702694204 no 2291 0.335578871583743 3200 25237072 SGTC_3178 9107506 49.47 µM -0.425530048115473 0.32470144512238 no 2292 0.335225160909881 3272 8897194 SGTC_2765 myclobutanil 7.74 µM -0.425765791556045 0.324611526677211 no 2293 0.335139258018649 3250 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1904 st060225 78 µM -0.426330357733372 0.324396228574839 no 2294 0.334933569992758 3230 66595 SGTC_1374 2889-5571 141 µM -0.426978674437171 0.32414906448451 no 2295 0.334697430256684 3193 2853281 SGTC_1663 st014140 55.4 µM -0.427036824839307 0.324126899025485 no 2296 0.334676253028715 3223 4207120 SGTC_1539 benzyladenosine 56 µM -0.427583687356657 0.323918479405637 no 2297 0.33447712223562 3144 92208 A nucleotide analog. SGTC_2570 licareol 100 µM -0.428393086750078 0.323610103338622 no 2298 0.334182478515572 3196 443158 SGTC_3206 9114350 49.47 µM -0.429441090365121 0.323211000472759 no 2299 0.333801128050037 3237 17087243 SGTC_1755 st041960 45.185 µM -0.430054882284668 0.322977349399255 no 2300 0.333577859397651 3267 2257073 SGTC_3271 9137798 49.47 µM -0.430111429986839 0.322955826998805 no 2301 0.333557292964785 3245 6498326 SGTC_1160 4092-0570 10.5 µM -0.430876265501699 0.322664784196204 no 2302 0.33327917099216 3165 4994975 SGTC_1479 0549-0158 134 µM -0.431270832445075 0.322514682121833 no 2303 0.333135727944387 3202 5440202 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.431546937732336 0.322409662706842 no 2304 0.333035365616188 3217 77254 SGTC_2847 9005661 71.43 µM -0.432045247276515 0.322220161544897 no 2305 0.332854263874121 3232 2991449 SGTC_2373 9071805 200 µM -0.433587226615782 0.321634058085711 no 2306 0.332294106038032 3313 10149009 SGTC_3173 9105693 49.47 µM -0.436115432338994 0.320674052306794 no 2307 0.331376490461227 3337 17096658 SGTC_3277 9138724 49.47 µM -0.438389265787959 0.319811659349518 no 2308 0.330552063201706 3180 15943418 SGTC_781 4335-2806 94.4 µM -0.43995481125205 0.319218462863642 no 2309 0.329984918245202 3302 845254 SGTC_2849 9019321 12.99 µM -0.441586905450324 0.318600542978294 no 2310 0.329394080665986 3270 16489627 SGTC_1318 1280-3875 124 µM -0.442263879290504 0.318344384760143 no 2311 0.329149132883141 3232 373245 SGTC_1752 st044819 83.042 µM -0.443105271903509 0.31802613361815 no 2312 0.328844796072437 3166 441209 YML126C ERG13 SGTC_2133 5320837 200 µM -0.443450980988064 0.317895410385052 no 2313 0.328719783871579 3306 2841355 SGTC_2883 9059145 45.46 µM -0.444864009510046 0.317361336905885 no 2314 0.328209016611046 3131 16476510 SGTC_1664 st014217 9.02 µM -0.44496485095384 0.317323237017063 no 2315 0.3281725777265 3321 3982782 SGTC_661 1304-0007 33.6 µM -0.445613076883472 0.317078370687485 no 2316 0.32793838143542 3226 3117130 SGTC_2723 salbutamol 83.58 µM -0.447068150817859 0.316529010522916 no 2317 0.327412927032981 3256 9884233 β2-adrenoceptor agonist SGTC_3116 9124943 49.47 µM -0.44811512353101 0.316133978292557 no 2318 0.327035056949507 3206 41905195 YPL160W CDC60 SGTC_2481 5478948 45.16 µM -0.448658184224139 0.315929159206915 no 2319 0.326839126989454 3320 77792 SGTC_2977 9011197 71.43 µM -0.449605382094676 0.315572052226758 no 2320 0.326497503311764 3353 2704722 SGTC_595 3909-8003 73.7 µM -0.44965438470603 0.315553582230645 no 2321 0.326479833607664 3304 699517 SGTC_1813 st051246 8.6015 µM -0.451604573155155 0.314818894370188 no 2322 0.325776937452411 3265 5291959 SGTC_546 peri-Naphthalide 147 µM -0.453276834299294 0.31418949212872 no 2323 0.325174705877623 3210 223824 A penicillin ester. SGTC_2643 anethole 100 µM -0.45476182232012 0.313631027892584 no 2324 0.324640299475039 3269 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_366 0181-0206 4.31 µM -0.455083213325727 0.313510217483788 no 2325 0.324524687136809 3400 274874 SGTC_1728 st035614 33.7865 µM -0.456556251930215 0.312956760515965 no 2326 0.323995015000159 3249 15945546 SGTC_3183 9108214 49.47 µM -0.457984311433489 0.31242060540589 no 2327 0.323481856299507 3265 4974831 SGTC_478 N-arachidonylglycine 10 µM -0.458861399045355 0.312091505539258 no 2328 0.323166850020727 3255 5283389 SGTC_482 fipronil 114 µM -0.461242553882602 0.311198807706461 no 2329 0.322312297260399 3273 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1428 4049-0204 61.7 µM -0.461645047133392 0.311048021967171 no 2330 0.322167942396682 3328 X1428 SGTC_1314 1222-0010 41.1 µM -0.462990810333008 0.310544090116635 no 2331 0.321685477078098 3251 3526027 SGTC_685 1278-0033 54.9 µM -0.463194963303621 0.310467674413215 no 2332 0.321612313076152 3342 3590572 SGTC_1149 3909-7961 23.3 µM -0.463375392017301 0.310400145652479 no 2333 0.321547657092887 3249 735261 SGTC_1736 st036774 51 µM -0.463601202403303 0.310315640970921 no 2334 0.321466746365858 3414 1272247 SGTC_2602 kawain 100 µM -0.46373926242175 0.310263979909791 no 2335 0.321417281881178 3305 5369129 SGTC_2346 9031566 143.75 µM -0.463883182397894 0.310210130080346 no 2336 0.321365721247661 3248 4771086 SGTC_92 0063-0024 660.874 µM -0.467121125019926 0.308999682452881 no 2337 0.320206610479507 3289 3594437 SGTC_1550 gossypolone 36.6 µM -0.467787443620042 0.30875084754327 no 2338 0.319968300411363 3263 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3305 9127027 53.8275 µM -0.468831922917336 0.308360966191563 no 2339 0.319594889963263 3208 41905295 SGTC_777 1315-0167 517 µM -0.468834589177893 0.308359971210907 no 2340 0.319593936985677 3275 4221767 SGTC_1756 st041558 35.5 µM -0.469385341307221 0.308154474705053 no 2341 0.319397112139194 3394 3955792 SGTC_2239 6685329 187.64 µM -0.470624663594017 0.307692278990744 no 2342 0.318954395895207 3328 805680 SGTC_86 0417-1630 471.922 µM -0.470679508769179 0.307671831947823 no 2343 0.318934809817511 3317 3634867 SGTC_468 gf-109203x 121 µM -0.471038076128708 0.307538167779292 no 2344 0.31880677221422 3251 2396 A protein kinase C inhibitor. SGTC_2354 9060492 162 µM -0.471117926099225 0.307508405357754 no 2345 0.318778262247647 3341 6471895 SGTC_2181 6316240 54.2555 µM -0.471121601994552 0.307507035274467 no 2346 0.318776949816466 3298 12779990 SGTC_2350 9023895 38.85 µM -0.473270320400583 0.306706622952029 no 2347 0.318010166956993 3352 2997209 SGTC_380 3970-0968 6 µM -0.475153350794035 0.306005938088788 no 2348 0.317338837111458 3182 2891601 SGTC_1485 3909-9022 254 µM -0.476000694069423 0.305690868722139 no 2349 0.317036941715049 3310 714516 SGTC_1278 0874-0585 172 µM -0.476024729143884 0.30568193380792 no 2350 0.317028380161908 3280 766306 SGTC_2056 5235370 200 µM -0.476134778441623 0.305641025030139 no 2351 0.316989180664438 3213 5511916 SGTC_1242 0402-0103 60.1 µM -0.476595267965639 0.305469872939198 no 2352 0.316825176839788 3222 432868 SGTC_2988 9073640 71.4286 µM -0.476789084101444 0.30539784918345 no 2353 0.316756159780761 3416 9102229 SGTC_3283 9109332 35.8195 µM -0.476976565821094 0.30532818651832 no 2354 0.316689404447259 3227 17027281 SGTC_1097 itavastatin 7.23 µM -0.478488845488713 0.304766526047325 no 2355 0.316151155796664 3277 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2326 6164455 177.58 µM -0.478850339159188 0.304632335389987 no 2356 0.316022551052024 3273 2888790 SGTC_2366 9070441 60.58 µM -0.483351341959849 0.302963716522355 no 2357 0.314423145508044 3249 6837235 SGTC_2023 5144124 124 µM -0.48366633741993 0.302847094199406 no 2358 0.314311343525795 3216 2830192 SGTC_253 dyclonine 31.25 µM -0.485807240268545 0.302054990335152 no 2359 0.313551920206856 3342 3180 An oral anasthetic. SGTC_835 0312-0010 67.2 µM -0.485985928959495 0.301988920124461 no 2360 0.313488571223705 3221 1626196 SGTC_1067 clotrimazole 1.36 µM -0.486093800402934 0.301949037760131 no 2361 0.313450331140235 3263 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_360 0957-0399 1.01 µM -0.486755128287399 0.301704582529303 no 2362 0.313215936349635 3369 6752301 YPR165W RHO1 SGTC_843 0310-0051 143 µM -0.487883226164514 0.30128779453734 no 2363 0.312816278168384 3299 2065037 SGTC_1056 3448-1962 115 µM -0.488136131348927 0.301194391566943 no 2364 0.312726710053605 3330 715507 SGTC_747 3448-8087 38.7 µM -0.4886814839609 0.300993026285942 no 2365 0.312533607298796 3276 5168703 SGTC_2077 5212015 200 µM -0.489389924883842 0.30073153316236 no 2366 0.312282833793315 3257 780900 SGTC_717 1532-0246 73.2 µM -0.489661021973866 0.300631495453761 no 2367 0.312186893995142 3313 9561992 SGTC_1942 st076330 65.2 µM -0.490334599172008 0.300383003361894 no 2368 0.311948573797704 3403 24208414 SGTC_43 0570-0105 72.5 µM -0.490657676515528 0.30026384853192 no 2369 0.311834292837326 3288 1114046 YDL195W SEC31 SGTC_2991 9074669 71.4286 µM -0.491982423849895 0.299775489276312 no 2370 0.31136588435315 3404 17333109 SGTC_526 4469-0568 170 µM -0.493202745784815 0.299325944286539 no 2371 0.310934668977621 3270 2901964 SGTC_2748 diazoxide 86.69 µM -0.496494986971767 0.29811466898163 no 2372 0.309772611675947 3299 3019 A potassium channel activatior. SGTC_1465 k213-0056 144 µM -0.496552446716374 0.298093548338744 no 2373 0.309752347022177 3234 24048857 YMR208W ERG12 SGTC_1806 st050005 60.3 µM -0.497138218991053 0.297878273259422 no 2374 0.309545792394562 3285 5194765 SGTC_561 1550-0330 72.9 µM -0.497457705296728 0.297760889869951 no 2375 0.309433160690106 3265 6812934 SGTC_3286 9117135 37.221 µM -0.499327641419723 0.297074274798537 no 2376 0.308774292645071 3251 3438150 SGTC_1232 0279-0259 161 µM -0.500166180510544 0.296766609983822 no 2377 0.308479034761098 3307 1560000 SGTC_1600 coumarin 106 71.1 µM -0.500485948591494 0.296649323667514 no 2378 0.308366473866089 3418 100336 A hepatotoxic, DNA x-linker. SGTC_1657 st012939 43.4 µM -0.501634889707903 0.296228083932383 no 2379 0.307962186194631 3395 24207257 SGTC_1613 st002381 52.1 µM -0.502136457206886 0.296044278802972 no 2380 0.307785768396155 3370 551167 SGTC_2543 pimpinellin 60.67 µM -0.502680864795471 0.295844833699594 no 2381 0.307594332609191 3241 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1637 st007924 17.4 µM -0.502719442846944 0.29583070287435 no 2382 0.307580768988704 3304 683336 SGTC_2450 5739737 12.93 µM -0.504333357029033 0.295239817287443 no 2383 0.307013570310667 3371 2262825 SGTC_41 0478-0632 82.643 µM -0.504958635668941 0.295011036633297 no 2384 0.306793944543829 3411 3750424 SGTC_1340 1486-1359 257 µM -0.505060670597009 0.294973711241484 no 2385 0.306758111901378 3280 4309068 SGTC_3327 9140648 26.9345 µM -0.505128614896312 0.294948857747732 no 2386 0.306734252235594 3378 8029710 SGTC_12 0849-0099 9.267 µM -0.505364187953501 0.294862694437552 no 2387 0.306651533544363 3339 6071388 SGTC_798 1287-0182 476 µM -0.509368248199196 0.293399945383843 no 2388 0.305247064062034 3418 1649755 SGTC_1156 4092-0367 4.88 µM -0.511064797564984 0.292781183659141 no 2389 0.304652842285776 3324 1357585 SGTC_110 0850-0284 111.64 µM -0.511271969092033 0.292705666049576 no 2390 0.304580315062079 3280 3906265 SGTC_2647 atorvastatin 60.16 µM -0.511756076574594 0.292529235765957 no 2391 0.304410867228107 3352 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1508 1080-0625 72.9 µM -0.512573373254743 0.292231488730771 no 2392 0.30412489140974 3362 767111 SGTC_1041 0206-0046 107 µM -0.512720606817283 0.292177865479663 no 2393 0.304073386446087 3323 50494 SGTC_3161 9100388 49.47 µM -0.512898683678548 0.292113015052329 no 2394 0.304011097133617 3343 25236368 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.515316464981226 0.291233192905043 no 2395 0.303165947603726 3422 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2803 7707263 71.43 µM -0.516024115055291 0.290975915744249 no 2396 0.302918783314691 3269 2199229 SGTC_2755 lomerizine 42.69 µM -0.517612728003906 0.290398737996326 no 2397 0.30236424976773 3314 3949 A calcium channel blocker. SGTC_1461 k072-0203 53.8 µM -0.518087761647904 0.2902262520714 no 2398 0.30219851932113 3320 5418714 SGTC_1638 st008370 60.6 µM -0.518107661479167 0.29021902743953 no 2399 0.302191577528121 3390 24207134 SGTC_126 0417-1624 672.48 µM -0.518464999132749 0.290089310380151 no 2400 0.3020669371961 3465 41912 YDL195W SEC31 SGTC_2879 9041815 71.43 µM -0.519033695694888 0.289882924026668 no 2401 0.301868621928818 3354 4942971 SGTC_2711 st079103 59.1 µM -0.520170857956686 0.289470441766918 no 2402 0.301472247473598 3329 54693780 SGTC_576 1073-0113 22.7 µM -0.520926410482922 0.289196533121187 no 2403 0.301209018226732 3507 5439563 SGTC_1740 st038286 13.222 µM -0.521048806119964 0.289152172795142 no 2404 0.301166386184027 3447 716786 SGTC_2785 7756463 72.73 µM -0.521997312060571 0.288808510620279 no 2405 0.300836101044206 3278 2201551 SGTC_2796 7949634 45.45 µM -0.522610244166075 0.288586535702238 no 2406 0.30062275509792 3350 2971588 SGTC_2116 5511452 16.8835 µM -0.524700159369724 0.287830272487212 no 2407 0.299895823255536 3416 870744 SGTC_2 0422-0095 29 µM -0.525737375391646 0.287455290162065 no 2408 0.299535345749445 3324 6790840 SGTC_2745 rifampicin 24.3 µM -0.525788158907975 0.287436936448491 no 2409 0.299517701321378 3340 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1578 josamycin 24.2 µM -0.526002637867309 0.287359427540521 no 2410 0.299443187090752 3310 5282165 A P450 substrate. SGTC_869 0564-0080 44.1 µM -0.526572014004884 0.287153713040295 no 2411 0.299245415348603 3361 6843321 SGTC_2654 protoveratrine a 100 µM -0.527841137850576 0.286695432102955 no 2412 0.298804800961365 3342 5702278 A heart drug and vasodilator. SGTC_415 dibenzyl ketone 100 µM -0.528166014017174 0.286578175010614 no 2413 0.298692057874869 3369 7593 SGTC_1276 0871-0068 94.2 µM -0.528736762596754 0.286372230642839 no 2414 0.298494035541559 3359 3414906 SGTC_2966 9084041 48.03 µM -0.529466193117465 0.286109131055413 no 2415 0.298241045181624 3175 17741380 SGTC_728 3030-5151 22.5 µM -0.529741471048453 0.286009870425894 no 2416 0.298145595176822 3382 3125388 SGTC_2743 auranofin 4.32 µM -0.530075156039036 0.285889571132609 no 2417 0.298029911741001 3316 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1716 st033144 30.6155 µM -0.531677570854968 0.285312207883276 no 2418 0.297474664461193 3474 674617 SGTC_414 piperonyl butoxide 100 µM -0.531815917496319 0.285262386508431 no 2419 0.297426748599293 3309 5794 A potent inhibitor of cytochrome P450. SGTC_1606 st000094 49.2 µM -0.533297455007707 0.284729115446497 no 2420 0.296913844556902 3461 1242210 SGTC_1434 4073-0095 163 µM -0.535720001548086 0.283858160022833 no 2421 0.296076038986681 3436 24133745 SGTC_318 1488-0629 67.2 µM -0.535827244104435 0.283819633608695 no 2422 0.296038975661921 3420 3662576 SGTC_2078 5212016 200 µM -0.538248836549128 0.282950354383573 no 2423 0.295202634178825 3384 1899708 SGTC_3222 9128301 49.47 µM -0.538671477881017 0.282798769913224 no 2424 0.295056778782428 3327 4911358 SGTC_641 4092-0595 30 µM -0.539756469784993 0.282409805611113 no 2425 0.294682495338668 3432 786260 SGTC_2528 xanthyletin 44.79 µM -0.540485382118438 0.282148638683755 no 2426 0.29443116966251 3347 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1796 st049173 110.4 µM -0.541401062339661 0.281820718291615 no 2427 0.294115587566455 3421 94134 SGTC_441 propafenone 146 µM -0.541725302422958 0.281704646547183 no 2428 0.294003878221623 3360 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3345 9148410 3.559 µM -0.542506274663196 0.281425168079984 no 2429 0.293734893040292 3432 4903596 SGTC_1722 st034304 3.6505 µM -0.542521819890784 0.281419606428371 no 2430 0.293729540054994 3342 4036148 YLR033W RSC58 SGTC_212 3807-4682 38.772 µM -0.542735407023342 0.281343196242852 no 2431 0.293655996087554 3432 3125501 YBL034C STU1 SGTC_1321 1326-2144 215 µM -0.544450977302738 0.280729819403105 no 2432 0.293065587139038 3421 3513030 SGTC_1080 nisoldipine 24.4 µM -0.545715455558299 0.280278138285763 no 2433 0.292630773104255 3333 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1021 4476-0760 85.3 µM -0.547256317927842 0.279728206957692 no 2434 0.292101324813194 3338 746768 SGTC_90 0870-0863 4.608 µM -0.547343778331815 0.279697008187986 no 2435 0.292071286341192 3391 1738164 SGTC_1581 himbacine 57.9 µM -0.548060902202738 0.279441260332254 no 2436 0.291825042784622 3362 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2619 obliquin 87.91 µM -0.548933396355967 0.279130256014203 no 2437 0.291525579196048 3431 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3050 9093513 49.47 µM -0.549305942163051 0.278997511735091 no 2438 0.291397755075672 3450 25236664 SGTC_2136 5328288 199.296 µM -0.551469346869939 0.278227262030974 no 2439 0.290655987047256 3353 262395 SGTC_1129 3453-1384 223 µM -0.552785471764244 0.277759182156802 no 2440 0.290205158957814 3500 1084452 SGTC_279 1273-0055 2.93 µM -0.553996981769726 0.277328648767273 no 2441 0.289790455668748 3430 2847562 SGTC_1302 1159-0335 255 µM -0.555109117681586 0.276933717369602 no 2442 0.289410013347581 3392 649284 SGTC_423 5-fluorouracil 457 µM -0.556846588064914 0.276317274674809 no 2443 0.28881612506502 3351 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2920 7982904 15.77 µM -0.560639780664236 0.274973819295579 no 2444 0.28752156344511 3405 6456808 SGTC_694 1315-0438 43.2 µM -0.562004899628928 0.274491116510673 no 2445 0.287056340433127 3370 6793154 SGTC_3027 9089541 49.47 µM -0.56284489165698 0.274194305290587 no 2446 0.286770254289645 3476 9943819 SGTC_2932 9016711 44.54 µM -0.563244346882096 0.274053213405763 no 2447 0.286634254475082 3474 7117328 SGTC_446 go6976 132 µM -0.564339525151817 0.273666568758397 no 2448 0.286261543523109 3448 3501 A protein kinase C inhibitor. SGTC_1851 st056236 18.9 µM -0.564539288680997 0.273596072824174 no 2449 0.286193584844257 3513 5393171 SGTC_1421 4029-0249 71.4 µM -0.564888872175834 0.273472727512032 no 2450 0.286074676509739 3519 2894095 SGTC_639 0833-0042 114 µM -0.565150139316805 0.273380561283583 no 2451 0.285985823684102 3392 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1856 st057054 55.7 µM -0.565490575817631 0.273260489860396 no 2452 0.285870066294691 3549 1266018 SGTC_2661 dactinomycin 12.96 µM -0.565505279327843 0.273255304543831 no 2453 0.285865067215323 3434 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_734 2023-0417 80 µM -0.566907128324005 0.272761154674757 no 2454 0.2853886404424 3457 3935732 SGTC_1793 st048256 72.231 µM -0.568270012381923 0.272281165316175 no 2455 0.28492581897233 3441 672022 SGTC_1557 sumaresinolic acid 42.3 µM -0.569426589500473 0.271874163949286 no 2456 0.284533338259586 3416 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1908 st060353 56.5 µM -0.569571873878155 0.271823059547438 no 2457 0.284484054735613 3536 4227716 SGTC_1930 st074634 34.3 µM -0.570098724344269 0.271637777745655 no 2458 0.284305370162917 3420 684253 YOR116C RPO31 SGTC_2001 4023502 57.655 µM -0.572076042780109 0.270942959370415 no 2459 0.283635229364221 3444 108941 YCR052W RSC6 SGTC_1236 0330-0013 258 µM -0.574357886242545 0.270142236334205 no 2460 0.282862822522435 3408 4617066 SGTC_1281 0884-0031 11.8 µM -0.575761851871042 0.269650158794395 no 2461 0.282388080954493 3456 1548255 SGTC_2728 chlorpromazine 9.18 µM -0.575899833364733 0.269601821745518 no 2462 0.282341444129774 3450 2726 A thorazine and dopamine antagonist. SGTC_2589 lobaric acid 100 µM -0.577147869042496 0.269164812880651 no 2463 0.281919784811875 3408 73157 A novel microtubule depolymerizer. SGTC_2046 4110841 106 µM -0.577716675965075 0.268965758919699 no 2464 0.281727709317991 3500 44119630 YMR134W ERG29 SGTC_1445 4239-0156 97.7 µM -0.577947941071432 0.268884848840452 no 2465 0.28164963344567 3542 4008346 SGTC_633 0437-0093 97.7 µM -0.578604418147106 0.268655241316043 no 2466 0.281428061453221 3467 2831118 SGTC_125 0133-0007 11.75 µM -0.578691068813403 0.268624941991424 no 2467 0.281398821689132 3557 26541 SGTC_2866 9034245 58.44 µM -0.58059362594636 0.267960103846646 no 2468 0.280757184600754 3435 6462273 SGTC_769 0302-0231 76 µM -0.582158552405255 0.267413870640955 no 2469 0.280229944295685 3516 571869 YER009W NTF2 SGTC_306 1672-3436 11.6 µM -0.582442786781888 0.267314719728722 no 2470 0.280134234218054 3503 6797378 SGTC_1705 st027868 56.3335 µM -0.582579032105008 0.26726719916234 no 2471 0.280088362026099 3490 292948 SGTC_1511 0906-3109 28.5 µM -0.583359849764356 0.266994942538057 no 2472 0.279825540178438 3508 2882180 SGTC_2583 asiatic acid 100 µM -0.584442547851252 0.266617657717433 no 2473 0.279461303976737 3534 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3055 9094636 49.47 µM -0.584914888976095 0.266453146799346 no 2474 0.27930247336403 3552 25236176 SGTC_312 4092-0653 6.84 µM -0.585039641940277 0.266409705367153 no 2475 0.279260530942526 3481 1148278 SGTC_1139 k015-0024 46.9 µM -0.585250251304722 0.26633637518208 no 2476 0.279189730218602 3504 2766652 SGTC_1730 st033808 45.1 µM -0.587985222127029 0.265385038728122 no 2477 0.278271106010868 3408 1045166 SGTC_2397 5161689 200 µM -0.588457307536891 0.265221002514798 no 2478 0.278112690839309 3564 2259942 SGTC_1772 st048439 82.2 µM -0.589060634524377 0.265011438562848 no 2479 0.277910299689249 3470 2927068 YDL195W SEC31 SGTC_2696 st077691 74.316 µM -0.589312266418697 0.264924059791985 no 2480 0.277825908887543 3496 757133 SGTC_1771 st048882 4.1505 µM -0.589958228271627 0.264699817633311 no 2481 0.277609327360726 3378 4580403 SGTC_782 0083-0095 30.5 µM -0.590221624620268 0.264608408729622 no 2482 0.27752103811294 3512 3591729 An indicator and reagent. SGTC_1828 st055811 49 µM -0.590467924451139 0.264522947520946 no 2483 0.277438491956641 3495 5877589 SGTC_1037 k284-1091 78.7 µM -0.591941967167588 0.264011777326659 no 2484 0.276944724921974 3508 3334711 SGTC_1042 0350-0096 82 µM -0.592113911073861 0.263952183225471 no 2485 0.276887156094993 3478 3122515 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.592635766483465 0.263771355160809 no 2486 0.276712468703703 3553 688801 SGTC_1975 st070967 30.8 µM -0.593796888684667 0.263369241608505 no 2487 0.276323985142262 3534 261391 SGTC_1062 mesoridazine 14.2 µM -0.593987730558117 0.263303180246128 no 2488 0.276260159653206 3511 4078 A neuroleptic. SGTC_3007 9078383 71.4286 µM -0.59408127895898 0.26327080084836 no 2489 0.276228875805119 3461 6496995 SGTC_2278 7948257 134.34 µM -0.594649761594775 0.263074078791975 no 2490 0.27603880492781 3507 1247028 SGTC_548 1436-0017 110 µM -0.595043799202079 0.262937767112657 no 2491 0.275907097043677 3580 9677137 SGTC_1685 st024049 53.0905 µM -0.595614980243476 0.262740239319985 no 2492 0.275716233424643 3486 1941139 SGTC_1649 st011737 51.3 µM -0.596831684942175 0.262319727522704 no 2493 0.275309880638982 3469 1761035 SGTC_791 1348-1292 225 µM -0.598094377470022 0.261883686408907 no 2494 0.2748884808359 3536 5437054 SGTC_1693 xanthone 101.9 µM -0.598114548126689 0.261876723965385 no 2495 0.274881751840231 3496 7020 An insecticide. SGTC_1782 st039423 80.636 µM -0.598805052319756 0.261638435172426 no 2496 0.274651446399026 3425 2068169 SGTC_199 4063-0024 41.6 µM -0.599968863373216 0.261237063042294 no 2497 0.274263493337085 3529 306215 SGTC_203 k066-0004 30.888 µM -0.601182697516241 0.260818776397535 no 2498 0.273859153730356 3576 6795412 SGTC_768 0384-0033 77.3 µM -0.60128074851609 0.260785003117913 no 2499 0.273826504887178 3439 3965305 YMR134W ERG29 SGTC_1430 4049-0248 69.1 µM -0.601324272666172 0.260770012117423 no 2500 0.273812012911852 3553 22774488 SGTC_1377 2944-0135 198 µM -0.601651543313895 0.260657304660662 no 2501 0.273703055715655 3538 1894137 SGTC_613 3914-0030 117 µM -0.604359019499452 0.259725850175487 no 2502 0.272802487629691 3326 1145395 SGTC_589 1227-0070 34.1 µM -0.606907039922535 0.25885082505147 no 2503 0.2719563029408 3545 2841384 SGTC_686 1319-0111 510 µM -0.607396712769442 0.258682839592469 no 2504 0.271793834744302 3585 4562600 SGTC_1361 1608-0041 5.61 µM -0.607855549335644 0.258525483951817 no 2505 0.271641641541402 3523 X1361 SGTC_196 k015-0023 18.111 µM -0.608519110472763 0.25829800678996 no 2506 0.271421617562814 3517 5211998 SGTC_2441 5730946 39.09 µM -0.609312269364789 0.258026238038944 no 2507 0.271158738034127 3542 1774275 SGTC_881 0833-0569 170 µM -0.612114996694047 0.257067098057967 no 2508 0.270230838042779 3452 5418700 SGTC_405 ebelactone b 50 µM -0.612282904994263 0.25700969597058 no 2509 0.270175299031115 3493 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1507 4075-3230 155 µM -0.612650771862476 0.2568839582187 no 2510 0.270053639702452 3485 659771 SGTC_2817 7995342 71.43 µM -0.612818306973334 0.256826704938609 no 2511 0.269998242305594 3443 18879975 SGTC_3005 9076496 71.4286 µM -0.613091940449047 0.256733207993981 no 2512 0.26990777450399 3553 21368410 SGTC_287 k060-0039 29.6 µM -0.613160471987972 0.25670979444728 no 2513 0.269885119207711 3553 5861974 SGTC_2824 7998404 51.95 µM -0.613218910240191 0.256689830112832 no 2514 0.269865801322779 3504 837851 SGTC_1115 galangin 695.678 nM -0.613268671850458 0.256672830627904 no 2515 0.269849352213942 3592 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2945 9067681 61.76 µM -0.613394678108879 0.256629787184974 no 2516 0.2698077020556 3603 16456930 SGTC_1859 st055998 20 µM -0.613399650470543 0.256628088714965 no 2517 0.269806058555233 3576 676301 SGTC_2236 dapsone 200 µM -0.613985856006254 0.256427892398682 no 2518 0.269612336867099 3560 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.614546605614998 0.256236465770641 no 2519 0.269427092763704 3509 6708561 SGTC_3337 9144342 33.5465 µM -0.614681894205985 0.256190292609783 no 2520 0.269382409619827 3522 17682949 SGTC_3069 9117009 49.47 µM -0.61597979523247 0.255747547552747 no 2521 0.268953927485982 3419 41904981 SGTC_1458 k015-0034 6.33 µM -0.619097518372484 0.254685652230021 no 2522 0.267926059035369 3505 3598957 SGTC_134 0269-0018 6.916 µM -0.619669929662813 0.25449094033681 no 2523 0.267737558446356 3472 4378915 SGTC_3176 9106582 49.47 µM -0.620110035602861 0.254341286595379 no 2524 0.267592672749021 3470 17018027 SGTC_1746 st038117 42 µM -0.620520965038759 0.254201595695679 no 2525 0.267457427834905 3525 2898218 SGTC_2342 7990637 118.86 µM -0.622431817386638 0.253552551544718 no 2526 0.266828982153874 3562 2033102 YER133W GLC7 SGTC_1061 3448-9325 110 µM -0.623999310578055 0.253020784221911 no 2527 0.266314018916956 3546 723482 SGTC_2285 7945142 200 µM -0.624531966763352 0.252840215894052 no 2528 0.266139141749703 3566 2970608 SGTC_161 4065-0411 162.148 µM -0.624893613492518 0.252717657766295 no 2529 0.26602044210867 3525 1906281 YLR208W SEC13 SGTC_1709 st033179 39.1045 µM -0.625204905518486 0.252612189356238 no 2530 0.265918291361284 3543 573381 SGTC_1900 st060200 72.8 µM -0.626266735543765 0.252252606732214 no 2531 0.265570000507607 3558 688945 SGTC_389 tpck 16.7 µM -0.628190658974036 0.251601769314029 no 2532 0.264939524383066 3537 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1505 k297-0037 20.6 µM -0.631434317282476 0.250506495061429 no 2533 0.263878291724874 3507 4089396 SGTC_3225 9130819 49.47 µM -0.632913591925281 0.250007833917655 no 2534 0.263395035693909 3574 4547121 SGTC_2283 7944793 200 µM -0.632961999301779 0.249991524772301 no 2535 0.263379229394628 3538 2970533 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.63299217065741 0.249981359891769 no 2536 0.263369377887445 3581 5377381 SGTC_264 promethazine 12.5 mM -0.633895853138688 0.249677006438557 no 2537 0.263074396031408 3626 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1897 st060201 15 µM -0.633964821840569 0.249653786385078 no 2538 0.263051890065264 3536 611878 SGTC_2561 acetosyringone 100 µM -0.634183147254163 0.249580289189532 no 2539 0.262980652289987 3541 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_711 k292-0785 179 µM -0.63451524656422 0.249468513127398 no 2540 0.262872309946256 3597 4146315 SGTC_1558 st069300 45.6 µM -0.635071629200254 0.249281308717173 no 2541 0.262690849744323 3536 24208000 SGTC_1254 0550-0035 264 µM -0.635594175623778 0.249105557117245 no 2542 0.262520483356512 3589 15121435 SGTC_1012 4112-3522 18 µM -0.63655207693442 0.248783550884462 no 2543 0.262208324663585 3578 3112398 SGTC_1280 0880-0253 10.1 µM -0.637673708068545 0.248406787414557 no 2544 0.261843051929465 3537 6836607 SGTC_1847 st056231 15 µM -0.638758432914005 0.24804271048316 no 2545 0.261490046585128 3605 5393180 SGTC_3034 9090421 49.47 µM -0.63880470237774 0.248027186938621 no 2546 0.26147499440659 3521 17173761 SGTC_1105 epirubicin 18.1 µM -0.63906588538302 0.247939568975446 no 2547 0.261390035843761 3518 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2435 5706476 10.6 µM -0.640707327240014 0.247389299706917 no 2548 0.260856426352486 3583 5725375 SGTC_552 k242-0005 476 µM -0.640893155394592 0.247327044705375 no 2549 0.260796051580349 3605 4088318 SGTC_2495 cafestol 54.53 µM -0.642088580276786 0.246926761143433 no 2550 0.260407835102699 3604 16667697 An anti-infammatory. SGTC_2298 7976326 193.81 µM -0.642963990834309 0.246633853234937 no 2551 0.260123732792877 3487 2235818 SGTC_2194 5927483 104.545 µM -0.643369450369251 0.246498251625262 no 2552 0.259992200706386 3601 760979 SGTC_497 capsazepine 133 µM -0.64357038776582 0.246431065066293 no 2553 0.259927028825762 3535 2733484 A calcium channel blocker. SGTC_1180 1193-0155 285 µM -0.644389274520032 0.246157359002494 no 2554 0.25966151889605 3584 2921347 SGTC_872 0588-0139 234 µM -0.645076658147541 0.245927732685732 no 2555 0.259438754720649 3607 2047100 SGTC_3037 9091026 49.47 µM -0.6454480464703 0.24580371512175 no 2556 0.259318437962163 3598 25236398 YIL048W NEO1 SGTC_2096 5468907 200 µM -0.64548899895265 0.245790041930001 no 2557 0.259305172562884 3585 759785 SGTC_3104 9120930 49.47 µM -0.64624412042133 0.245537995591649 no 2558 0.259060635161413 3596 17014836 SGTC_1929 genistein trimethyl ether 50.5 µM -0.647007840870507 0.245283220358745 no 2559 0.258813434428307 3619 136420 SGTC_1334 1486-0610 236 µM -0.647408007529398 0.245149782523264 no 2560 0.258683957394291 3589 3742339 SGTC_2691 st077356 60.2 µM -0.648896141641973 0.244653898497047 no 2561 0.258202754404085 3628 2839272 SGTC_2474 5321570 43.32 µM -0.649797932279909 0.24435366202974 no 2562 0.257911377379884 3590 2841384 SGTC_2068 5226020 147 µM -0.651188082801155 0.243891223373628 no 2563 0.257462541115991 3600 1810509 SGTC_2759 disulfiram 3.38 µM -0.652130028984583 0.243578150138058 no 2564 0.257158646851787 3567 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1389 3405-0187 19 µM -0.652154217849842 0.243570113380676 no 2565 0.257150845404967 3527 799890 SGTC_1419 3993-2473 62.6 µM -0.653252998536185 0.243205194237938 no 2566 0.256796594010531 3623 704026 SGTC_1431 4049-0260 9.09 µM -0.653716470503588 0.243051357936226 no 2567 0.256647244955793 3591 3854841 SGTC_1590 st077108 57.8 µM -0.654550863735607 0.242774537609723 no 2568 0.256378484410915 3580 5489485 SGTC_3276 9139060 49.47 µM -0.655503972298495 0.242458540901571 no 2569 0.256071664857723 3658 4870619 SGTC_2117 5521686 200 µM -0.655944348799474 0.242312612336425 no 2570 0.255929965952607 3594 803312 SGTC_2891 9063876 19.48 µM -0.658773922617145 0.241376106452211 no 2571 0.255020477641813 3566 6472478 SGTC_780 0109-0199 192 µM -0.659940064345007 0.240990720729688 no 2572 0.254646146233941 3647 610414 SGTC_150 3970-0969 77.2 µM -0.661555176263138 0.240457512797986 no 2573 0.254128171104163 3632 6615640 SGTC_158 k038-0087 26.446 µM -0.661695349003038 0.240411266934116 no 2574 0.254083243024087 3576 X158 SGTC_1872 amphotericin b 148 nM -0.661870748039891 0.24035340601622 no 2575 0.254027030102429 3606 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_882 0843-0131 351 µM -0.662729418242149 0.240070256007944 no 2576 0.253751932578968 3638 5425421 SGTC_148 3253-0744 288.01 µM -0.663367746478671 0.239859882562803 no 2577 0.253547528794258 3602 6893655 SGTC_2518 prenyletin 46.28 µM -0.664542306507575 0.239473046430617 no 2578 0.253171640425006 3557 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2129 girgensonine 121.053 µM -0.666047281761968 0.23897788780412 no 2579 0.252690439663109 3654 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_133 0724-0033 378.92 µM -0.666844839980894 0.23871570672608 no 2580 0.252435623817593 3531 280309 SGTC_3026 9090633 49.47 µM -0.669693516492501 0.237780548342522 no 2581 0.251526592800424 3608 25236842 SGTC_605 1315-0399 119 µM -0.670693194166041 0.237452852886782 no 2582 0.251207999688423 3669 24020461 SGTC_115 0527-0192 112.043 µM -0.670795637819801 0.23741928575322 no 2583 0.251175363382126 3655 4233931 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.671650392654882 0.237139314637117 no 2584 0.250903144633166 3701 6710655 SGTC_1418 3966-3099 2.4 µM -0.672558211702109 0.236842161314537 no 2585 0.25061419730298 3632 740335 SGTC_893 0958-0369 48.9 µM -0.67300561696734 0.236695789019202 no 2586 0.250471858731251 3632 6819948 SGTC_3170 9103054 49.47 µM -0.674490759476595 0.236210269399934 no 2587 0.249999679274407 3598 16432970 SGTC_928 2764-0428 58.7 µM -0.674666831705932 0.236152744633785 no 2588 0.24994373100545 3644 662578 SGTC_1137 ixabepilone 100 µM -0.674957313930611 0.236057857712412 no 2589 0.249851442630616 3645 154225 A novel microtubule stabilizer. SGTC_3273 9137859 49.47 µM -0.67632941427741 0.235609940950402 no 2590 0.249415760730096 3702 2377234 SGTC_372 0155-0182 15.9 µM -0.679773368402685 0.234487743636836 no 2591 0.248323985938288 3631 771486 SGTC_1521 st012942 49.4 µM -0.680374207440966 0.234292266266435 no 2592 0.248133774106416 3680 24207259 SGTC_3164 9100705 49.47 µM -0.68050325919425 0.234250292253948 no 2593 0.24809292942791 3638 17174235 SGTC_776 4476-4378 112 µM -0.682609435929595 0.233565848083122 no 2594 0.247426834996456 3649 2892008 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.683017050630848 0.233433513751769 no 2595 0.247298034216522 3649 4330530 SGTC_1003 4049-0218 100 µM -0.683471682950266 0.233285963974652 no 2596 0.247154418796458 3673 295161 SGTC_730 1436-0052 41.2 µM -0.684819748926576 0.232848756962751 no 2597 0.246728835802117 3672 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1355 1499-0035 1.68 µM -0.685242701290799 0.232711678222857 no 2598 0.246595391105865 3660 1548538 SGTC_262 fenpropimorph 62.5 µM -0.686405474582957 0.232335054971921 no 2599 0.246228726592661 3613 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2506 ethyl hematommate 54.16 µM -0.689043487842886 0.231481858891316 no 2600 0.24539795060184 3657 3940691 An allergen. SGTC_920 mycophenolic acid 780.421 nM -0.689498049060802 0.231335019643324 no 2601 0.245254950268173 3670 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2926 9010726 65.15 µM -0.690223324851996 0.231100837685995 no 2602 0.245026878681623 3656 2994293 SGTC_424 splitomicin 100 mM -0.690415645082921 0.23103876222733 no 2603 0.244966420445031 3657 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2405 ticlatone 3.52 µM -0.690690295391279 0.230950129117229 no 2604 0.244880094650661 3582 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3006 9075424 71.4286 µM -0.691084504546084 0.230822946046743 no 2605 0.244756218735315 3661 7465181 SGTC_1186 1319-0216 26 µM -0.691266460268394 0.230764255158863 no 2606 0.244699052520957 3709 4565136 SGTC_1237 0330-0133 46.1 µM -0.692896161636298 0.230238957226702 no 2607 0.244187359331648 3619 X1237 YHR072W ERG7 SGTC_336 4111-0029 111 µM -0.693529611152367 0.230034959525225 no 2608 0.243988624841943 3613 3131175 SGTC_3101 9120531 49.47 µM -0.694307094123732 0.229784715237167 no 2609 0.243744821516816 3717 24824904 SGTC_1309 pyrazolanthrone 13.4 µM -0.69470646612338 0.229656230791466 no 2610 0.243619637480882 3680 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1932 st074806 40.9 µM -0.694986718643501 0.229566093045694 no 2611 0.243531812443311 3764 17251235 SGTC_2552 juarezic acid 87.02 µM -0.696891814217501 0.228953881894591 no 2612 0.24293525048022 3726 1549512 SGTC_2915 7971052 15.16 µM -0.698233547053399 0.228523260327341 no 2613 0.242515574977441 3543 5741558 SGTC_553 k007-0256 45.7 µM -0.69824184202245 0.228520599519757 no 2614 0.242512981647555 3702 6287000 SGTC_1690 st023502 41.2 µM -0.699835350177223 0.228009766991563 no 2615 0.242015067740519 3652 24207482 SGTC_369 0957-0393 4.5 µM -0.701585918965832 0.227449326495496 no 2616 0.241468717770428 3668 6997992 SGTC_2394 5221648 200 µM -0.705296648372084 0.22626391455291 no 2617 0.240312822904214 3753 788586 SGTC_81 0411-0046 9.971 µM -0.705984788411294 0.226044468890803 no 2618 0.240098798636795 3583 12925265 SGTC_1339 1486-1321 22.7 µM -0.706633103929922 0.225837833248972 no 2619 0.239897255631658 3720 3469382 SGTC_66 0109-0187 42.4 µM -0.707006811760701 0.225718771037457 no 2620 0.239781122348011 3679 759417 SGTC_1910 st062352 60.4 µM -0.707180749659286 0.225663367048862 no 2621 0.239727079944445 3643 2245730 SGTC_1000 4048-0884 8.67 µM -0.707658092554731 0.225511359790779 no 2622 0.239578803939633 3679 13040088 SGTC_936 3005-4620 401 µM -0.708332117855659 0.225296818812637 no 2623 0.239369518183671 3696 777207 SGTC_20 0481-0013 4.944 µM -0.709363237404898 0.224968839181457 no 2624 0.239049547505252 3685 182045 SGTC_1811 st050069 61.5 µM -0.711941708788123 0.224149861759387 no 2625 0.238250436492187 3674 3877702 SGTC_1647 st011722 22.4 µM -0.713280598923963 0.223725270504276 no 2626 0.237836070180003 3689 2854783 SGTC_2149 5554786 194.827 µM -0.71341298068295 0.223683314216515 no 2627 0.237795121502794 3732 745063 YPR165W RHO1 SGTC_861 0443-0273 110 µM -0.714400286034245 0.22337054466459 no 2628 0.237489847583064 3719 6149169 SGTC_2749 bexarotene 57.39 µM -0.714686387062724 0.223279956930398 no 2629 0.237401425621736 3717 82146 An retinoic acid receptor inhibitor. SGTC_25 0118-0223 35.662 µM -0.714910724139247 0.223208940050501 no 2630 0.237332104981213 3723 5333628 SGTC_2886 9058944 51.95 µM -0.716515951114094 0.222701159461797 no 2631 0.236836410849528 3570 4949929 SGTC_1650 st011916 45.8 µM -0.71998212644126 0.221606954836125 no 2632 0.235768000212243 3677 242528 SGTC_736 0958-0254 92.6 µM -0.720121030854763 0.221563169520083 no 2633 0.235725239901538 3759 6812352 SGTC_856 0433-0016 11.3 µM -0.721158169866893 0.221236399885311 no 2634 0.235406102422125 3724 3911780 SGTC_2721 ifenprodil 61.44 µM -0.721162940799927 0.221234897352763 no 2635 0.235404634912129 3703 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3247 9135149 49.47 µM -0.721313100102251 0.221187609955204 no 2636 0.235358449404032 3678 8934436 YOR116C RPO31 SGTC_1050 3232-1156 69.3 µM -0.725573265790195 0.219848431626348 no 2637 0.234050207549137 3699 700529 SGTC_634 1611-4317 11.2 µM -0.727405681346558 0.219273848230202 no 2638 0.233488737588283 3738 2843522 SGTC_688 0527-0193 473 µM -0.727791647720518 0.219152932400523 no 2639 0.233370569060497 3749 4007154 SGTC_2783 7738165 71.43 µM -0.729351348238472 0.218664698907461 no 2640 0.232893384988535 3701 17201110 SGTC_979 1426-2828 121 µM -0.729765093216446 0.21853528934876 no 2641 0.232766892408129 3812 747872 SGTC_2914 7968218 45.32 µM -0.729869229097922 0.218502725076983 no 2642 0.232735061380642 3691 2977111 SGTC_2267 7931562 200 µM -0.73035107774368 0.218352082844994 no 2643 0.23258780707006 3641 934880 SGTC_914 3820-6779 408 µM -0.730901071331956 0.218180209330802 no 2644 0.232419790794844 3705 2893481 SGTC_1993 st073995 70.8 µM -0.731132954122614 0.218107769111525 no 2645 0.232348973690335 3734 3098394 SGTC_1980 st071811 45.7 µM -0.731349511781849 0.218040128986365 no 2646 0.232282847728757 3788 4974850 SGTC_3329 9141233 27.5565 µM -0.73185301781421 0.217882909488038 no 2647 0.232129142456917 3722 4909101 YNL103W MET4 SGTC_852 0418-0143 439 µM -0.734893044693247 0.216935052710528 no 2648 0.231202317311626 3761 5369229 SGTC_816 0325-0417 81.3 µM -0.735103376816459 0.216869561062926 no 2649 0.231138268972215 3748 68101 SGTC_3352 9151559 45.5865 µM -0.735514786504089 0.216741492432815 no 2650 0.231013019031621 3724 17159339 SGTC_2959 9079155 11 µM -0.736077773298268 0.216566309923838 no 2651 0.230841684229459 3721 16189457 SGTC_2695 st077686 51.995 µM -0.736115250370956 0.216554651231086 no 2652 0.230830281283033 3766 2876092 SGTC_2880 9042983 58.44 µM -0.737512063801242 0.216120377441209 no 2653 0.230405504826007 3736 6464714 SGTC_2256 7954252 200 µM -0.738965634134666 0.215668993735148 no 2654 0.229963932760497 3700 2972920 SGTC_1397 3532-0190 20.1 µM -0.741058761688744 0.215019966638338 no 2655 0.229328906075609 3661 5322280 SGTC_98 0074-0023 107.663 µM -0.741222612242345 0.21496920854407 no 2656 0.229279237549193 3697 3563821 SGTC_2525 harmine 47.85 µM -0.745082012171722 0.213775646304532 no 2657 0.228111071287006 3748 5280953 A monoamine oxidase inhibitor SGTC_2193 5925765 200 µM -0.745448607655142 0.213662473651324 no 2658 0.228000284192896 3735 877370 SGTC_3163 9099914 49.47 µM -0.745524204265089 0.213639140365159 no 2659 0.227977442262118 3746 16268368 SGTC_2532 xanthone 78.9 µM -0.746925078483982 0.213207021977277 no 2660 0.227554393442308 3672 7020 An insecticide. SGTC_395 anisomycin 6.25 µM -0.747438425970205 0.21304880078544 no 2661 0.227399478818126 3742 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1863 st057641 20.1 µM -0.748615110611108 0.212686387967067 no 2662 0.227044610936759 3766 3921635 SGTC_2263 7948595 193.29 µM -0.752301779973214 0.211553246073089 no 2663 0.225934798839856 3748 2971371 SGTC_1273 0849-0096 14.1 µM -0.752512216772521 0.211488672619345 no 2664 0.225871542921909 3779 5286025 SGTC_2175 5807670 165.306 µM -0.752784985967306 0.211404989374901 no 2665 0.225789565201818 3710 241186 SGTC_2929 9013348 24.6 µM -0.753355749538743 0.211229946775634 no 2666 0.225618083076623 3790 2995952 SGTC_2460 5552655 174.22 µM -0.753389135168559 0.211219710651832 no 2667 0.225608054867734 3741 5401989 SGTC_3092 9117248 49.47 µM -0.754747373520309 0.210803517618005 no 2668 0.225200287931282 3828 17141857 SGTC_474 dl-dihydrosphingosine 5 µM -0.754900919017224 0.210756498300582 no 2669 0.225154217163681 3764 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3317 9138495 8.753 µM -0.756095996369937 0.210390747245454 no 2670 0.224795821108591 3731 17020139 SGTC_903 1134-0042 114 µM -0.757136887821447 0.210072488308312 no 2671 0.224483928159463 3761 701009 SGTC_954 1189-0853 2.85 µM -0.757170425819542 0.210062238565663 no 2672 0.224473882911288 3733 2828194 SGTC_522 1273-0010 11.6 µM -0.757792368900411 0.209872216175302 no 2673 0.22428764573459 3831 5705015 SGTC_2210 7115885 190.385 µM -0.758124653229883 0.209770734703344 no 2674 0.224188181121948 3795 2927039 SGTC_2452 5863136 48.41 µM -0.759063437447738 0.209484180747876 no 2675 0.223907304742638 3736 2184096 SGTC_705 1124-0212 310 µM -0.759600669339968 0.209320300047619 no 2676 0.223746659462002 3736 9554485 SGTC_1719 st032227 49.2 µM -0.759605660093837 0.209318777989508 no 2677 0.223745167413577 3792 3125804 SGTC_2319 6033012 152.6 µM -0.76006305973124 0.209179309921484 no 2678 0.223608446075642 3744 847246 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.76033039799173 0.209097819780931 no 2679 0.223528557993494 3768 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2142 5622915 118.518 µM -0.760832488882962 0.20894482279571 no 2680 0.223378563203841 3782 5322196 SGTC_2332 7982454 138.89 µM -0.761308533513852 0.20879982353801 no 2681 0.223236402389307 3741 2981748 SGTC_3189 9110682 49.47 µM -0.76197436836045 0.208597115244668 no 2682 0.223037651093986 3856 17122418 SGTC_1677 st019204 53.9 µM -0.762219826250517 0.208522416757324 no 2683 0.222964407493538 3801 3945625 SGTC_1143 3454-2408 5.08 µM -0.765478480949572 0.207532228607407 no 2684 0.22199333780269 3724 X1143 SGTC_1742 st038235 28.8875 µM -0.765889288829704 0.207407596387205 no 2685 0.221871089869918 3814 564103 YBR002C RER2 SGTC_946 3434-1334 87.4 µM -0.767512678322804 0.206915520328122 no 2686 0.221388379056394 3774 4047976 SGTC_1959 st077091 55.8 µM -0.769878149562299 0.206199745303823 no 2687 0.220686088238753 3790 821356 YKL052C ASK1 SGTC_1964 st076914 61 µM -0.770018623592756 0.20615728506903 no 2688 0.220644422722324 3826 24208661 SGTC_2670 beta-carotene 100 µM -0.770174448234713 0.206110190962637 no 2689 0.220598209386343 3704 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_687 k029-0044 34.9 µM -0.770478580960721 0.206018292818508 no 2690 0.220508027895878 3803 5829338 SGTC_2533 agelasine 13.65 µM -0.770608198911156 0.205979134248438 no 2691 0.220469599979311 3817 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2827 7993847 71.43 µM -0.770814474114244 0.205916826042041 no 2692 0.220408453352475 3829 2985692 SGTC_1066 ketoconazole 628 nM -0.771049447883867 0.205845862670563 no 2693 0.220338811388877 3839 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.771266297746508 0.205780385694297 no 2694 0.220274552216749 3757 2724278 An inhibitor of dopamine biosynthesis. SGTC_899 1083-0020 478 µM -0.772791127226579 0.205320318436275 no 2695 0.21982300265974 3835 767123 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.775069967258617 0.204633893271363 no 2696 0.21914915843162 3784 6312947 SGTC_1214 0358-0031 63.7 µM -0.777560070861379 0.203885395152965 no 2697 0.21841420403207 3926 4301366 SGTC_167 3672-0051 66.205 µM -0.778749437241435 0.203528461066813 no 2698 0.218063663961668 3745 3237971 SGTC_1001 4048-4355 44.4 µM -0.779135652926903 0.203412636250961 no 2699 0.217949905015299 3798 21824233 SGTC_2703 st077852 53.4 µM -0.782935092522958 0.202275294561598 no 2700 0.216832614371459 3803 6281836 SGTC_621 3584-0052 32.1 µM -0.78337307557691 0.202144431664855 no 2701 0.216704031125373 3791 2273927 SGTC_2436 5633522 8.09 µM -0.78547441625401 0.201517286837661 no 2702 0.216087732315355 3770 5724242 SGTC_1319 1306-0155 43.7 µM -0.786118856274934 0.201325187645521 no 2703 0.215898929146363 3848 3122360 SGTC_1174 0739-0097 51.1 µM -0.787385531507952 0.200947928296326 no 2704 0.215528106927262 3819 728447 SGTC_1142 3253-1408 9.78 µM -0.787480657587394 0.20091961361803 no 2705 0.215500273458993 3760 256655 SGTC_2809 7964133 12.99 µM -0.788707130250865 0.200554763300633 no 2706 0.215141599771936 3845 1253665 SGTC_2143 5623677 140.463 µM -0.788736829763855 0.200545933244627 no 2707 0.215132918648626 3771 5375313 SGTC_2840 9008771 71.43 µM -0.788827895546773 0.200518859644513 no 2708 0.215106301523951 3784 2992978 SGTC_1881 5652484 16 µM -0.790197864020441 0.200111836821767 no 2709 0.214706111637616 3764 2255129 SGTC_2019 4016004 108 µM -0.791372043525105 0.199763379181019 no 2710 0.214363459446555 3845 45595336 SGTC_1271 0832-2808 169 µM -0.794121461033208 0.198948872279595 no 2711 0.213562362480386 3866 3663794 SGTC_327 1273-0057 3.96 µM -0.795345820669734 0.198586804335832 no 2712 0.213206183305514 3733 3108138 SGTC_1988 st071872 53.4 µM -0.795447272834645 0.198556820716605 no 2713 0.21317668534756 3818 16414116 SGTC_1768 st044301 37.178 µM -0.79622601022098 0.198326760181258 no 2714 0.212950341034238 3831 3931349 SGTC_1074 carmofur 3.8 µM -0.796594773175505 0.198217873567243 no 2715 0.212843206995747 3850 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2155 5570423 76 µM -0.798637115727306 0.197615473794018 no 2716 0.212250429835948 3784 797402 SGTC_270 tamoxifen 5.46 µM -0.802188537146913 0.196570602029859 no 2717 0.211221953054363 3870 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2196 6573537 42.6665 µM -0.80239481637077 0.196510015182233 no 2718 0.211162305317625 3839 2903087 SGTC_3310 9130229 44.1445 µM -0.806764601678444 0.195229213672681 no 2719 0.209901058447204 3920 7761258 SGTC_3311 9131146 2.8755 µM -0.808998933160025 0.194576286795345 no 2720 0.209257879961539 3828 4900406 YPR165W RHO1 SGTC_527 4476-4215 268 µM -0.809650856367139 0.19438602943861 no 2721 0.209070435078975 3850 4418754 SGTC_159 3970-0959 50 µM -0.809953613889863 0.194297711168039 no 2722 0.208983418047327 3918 6615653 SGTC_3288 9119690 36.221 µM -0.810566135079404 0.194119105582787 no 2723 0.20880743556351 3849 17595618 YKL019W RAM2 SGTC_3318 9139014 38.6185 µM -0.813818783370797 0.193172339777007 no 2724 0.20787438646505 3830 16643984 SGTC_2958 9077254 16.72 µM -0.814230252798143 0.193052772328181 no 2725 0.207756528733986 3885 16457351 SGTC_335 4077-0256 27.6 µM -0.816095263179395 0.192511392356074 no 2726 0.207222826453885 3837 3121989 SGTC_1111 tnp00062 510.699 nM -0.81620931491687 0.19247831526792 no 2727 0.207190215071835 3929 676306 SGTC_314 1671-0008 2.74 µM -0.817142372106627 0.192207842135962 no 2728 0.20692353539295 3772 3913060 SGTC_971 1315-0384 26.7 µM -0.818057603601715 0.191942762289329 no 2729 0.206662147987595 3887 6769120 SGTC_1329 1447-1697 50.6 µM -0.818075503694606 0.191937580091017 no 2730 0.206657037724312 3869 2840515 SGTC_2818 7996756 12.99 µM -0.818499944146227 0.191814726792431 no 2731 0.20653588695688 3856 2241621 SGTC_1070 indatraline 8.81 µM -0.819145279167745 0.191628028348384 no 2732 0.206351765465023 3848 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_542 3381-0244 89.3 µM -0.81920263159533 0.191611441409597 no 2733 0.206335406866639 3905 1112843 SGTC_2265 7929201 200 µM -0.821302612683222 0.191004710046155 no 2734 0.20573695994075 3830 1265108 SGTC_3237 9133362 49.47 µM -0.821367660461142 0.190985935126905 no 2735 0.205718439263294 3799 43845137 SGTC_823 0417-1665 178 µM -0.821831749788962 0.19085201659608 no 2736 0.205586330509375 3890 3429856 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.822572607498967 0.190638352666615 no 2737 0.205375540624579 3829 16623 A steroid. SGTC_379 3970-0972 5.9 µM -0.824215135190356 0.19016517031325 no 2738 0.204908664340422 3862 2898042 YBL034C STU1 SGTC_2774 tamoxifen 10.92 µM -0.825427865334603 0.18981626835515 no 2739 0.204564360126955 3875 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2177 5811945 192 µM -0.825468814641071 0.189804494130979 no 2740 0.204552740288374 3891 5343475 SGTC_925 2064-1272 59.6 µM -0.82557728730637 0.189773306970496 no 2741 0.204521961815242 3851 6815817 SGTC_67 0335-0847 266 µM -0.826397371082625 0.189537625278132 no 2742 0.20428935712016 4048 4552207 YOR254C SEC63 SGTC_1211 1056-0033 32.3 µM -0.826970028364098 0.189373157661507 no 2743 0.204127024747266 3851 6741922 SGTC_2762 leflunomide 42.06 µM -0.827521866260503 0.189214752524929 no 2744 0.20397066680645 3844 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_623 k072-0108 16.9 µM -0.828640452458103 0.18889391260212 no 2745 0.203653945226746 3868 5382803 SGTC_2246 7293507 91.5585 µM -0.830042673623121 0.188492192505083 no 2746 0.203257328443925 3927 887656 SGTC_3296 9122258 64.045 µM -0.830159601150292 0.188458717939842 no 2747 0.203224276452002 3904 4730474 SGTC_1968 st069590 43.6 µM -0.830763896183914 0.188285775943575 no 2748 0.2030535110581 3874 6384066 SGTC_3036 9090181 49.47 µM -0.830804393647146 0.188274189556731 no 2749 0.203042070100887 3894 25236586 SGTC_2902 5787006 60.46 µM -0.832587920301481 0.187764356181146 no 2750 0.202538587010821 3835 591003 SGTC_2725 haloperidol 53.21 µM -0.834048603864461 0.187347445526254 no 2751 0.202126797807651 3830 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2428 5615643 7.78 µM -0.837989844662608 0.186225388483447 no 2752 0.201018203528699 3931 2253075 SGTC_1739 st037196 92.5 µM -0.838844590792026 0.185982595972115 no 2753 0.200778262244929 3938 612214 SGTC_455 paf C-16 10 µM -0.842757979722842 0.184873497405499 no 2754 0.199681906619146 3864 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1486 3970-0793 4.53 µM -0.844571245393683 0.184360993945249 no 2755 0.199175134631118 3936 2844330 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.845441121212852 0.184115445306961 no 2756 0.198932296717717 3940 4174840 SGTC_245 methotrexate 289.6 µM -0.848287246880602 0.183313464304602 no 2757 0.198139009115697 3896 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2443 5493264 126.67 µM -0.848440265639846 0.183270408487216 no 2758 0.198096413068576 3924 5340055 SGTC_2368 9071271 200 µM -0.848498616230297 0.183253991688335 no 2759 0.198080171389051 3909 27209959 SGTC_3241 9133421 49.47 µM -0.848672691876198 0.183205021371416 no 2760 0.198031722829289 3896 17018221 SGTC_1977 st070720 65.3 µM -0.849599355970592 0.182944473043848 no 2761 0.197773935070651 3927 682188 SGTC_1540 guanosine 70.6 µM -0.850031311193022 0.18282310009501 no 2762 0.197653839200093 3789 6802 Guanosine is a purine nucleoside SGTC_1668 st014914 51.6 µM -0.85270973901954 0.182071624543485 no 2763 0.196910144375634 3917 2839556 SGTC_3158 9100007 49.47 µM -0.853557112783916 0.181834283035589 no 2764 0.196675214982317 3931 19297233 SGTC_2515 chrysin 20.77 µM -0.853649574273195 0.18180839714801 no 2765 0.196649590855579 3935 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1157 4092-0394 27.6 µM -0.855902921565022 0.181178253829664 no 2766 0.196025739412677 4013 3659885 SGTC_274 sirtinol 40.1 µM -0.856115454404593 0.181118890198476 no 2767 0.195966960561467 3968 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.858292794521888 0.180511428240714 no 2768 0.195365403593932 3949 5357218 A potent inhibitor of glutathione S-transferases. SGTC_401 neomycin 50 µM -0.859443793014824 0.180190825031982 no 2769 0.195047858708855 3896 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1406 3909-7906 11.9 µM -0.859525274414276 0.180168142467845 no 2770 0.195025390993594 3925 X1406 SGTC_1747 st037496 66.6 µM -0.86068551744721 0.179845351738269 no 2771 0.19470563583311 3922 723305 SGTC_1107 amlodipine 47 µM -0.863206024760019 0.179145375102702 no 2772 0.194012100895304 3710 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_8 0354-0001 70 µM -0.863347266752929 0.179106201195494 no 2773 0.193973281777038 3909 4993152 SGTC_1694 st024011 44.9 µM -0.864069708399097 0.178905914037611 no 2774 0.193774799078424 3936 2787533 SGTC_1545 lovastatin 49.4 µM -0.86786325253094 0.177856520124946 no 2775 0.192734599025273 4014 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_172 1112-0046 2.638 µM -0.867921746932196 0.17784036949107 no 2776 0.192718586458842 3895 2802135 YIL048W NEO1 SGTC_2172 5754775 163.918 µM -0.868588318592326 0.17765639063686 no 2777 0.192536173027406 3909 2263357 SGTC_807 1315-0151 48 µM -0.868701864286765 0.177625063136018 no 2778 0.192505110733491 3917 4011080 SGTC_2182 6325192 200 µM -0.869833547588378 0.177313019822264 no 2779 0.192195687591346 3847 736248 SGTC_1721 st082152 9.2685 µM -0.871189670220199 0.176939547236138 no 2780 0.191825299586296 3873 5296051 SGTC_2303 7774051 200 µM -0.871414986810262 0.176877543835744 no 2781 0.191763802851995 3902 2953184 SGTC_1028 k015-0029 4.8 µM -0.871745812322886 0.176786531010765 no 2782 0.191673530940586 3886 4588309 SGTC_2156 5649887 115 µM -0.872695463758195 0.176525438568419 no 2783 0.191414545448723 3980 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_284 0988-0104 32.6 µM -0.874764726884815 0.175957370850736 no 2784 0.190850966667733 3921 4666532 SGTC_1983 st071813 46.9 µM -0.874909715051486 0.175917611189086 no 2785 0.190811516294234 3994 11838595 SGTC_1020 4335-0961 93.3 µM -0.877234750671222 0.175280801084894 no 2786 0.190179572299652 3878 669075 SGTC_2709 st078560 56 µM -0.877463230879004 0.175218301019488 no 2787 0.190117540916984 3916 17250903 SGTC_590 k048-0076 22.4 µM -0.877570890625431 0.17518885592301 no 2788 0.190088316074179 3957 6832814 SGTC_1331 1472-0049 76.2 µM -0.880644324282719 0.174349591243341 no 2789 0.189255180023178 3895 24051409 SGTC_149 3970-0822 46.1 µM -0.883157673564002 0.173665171047531 no 2790 0.188575543425596 3958 3114250 YBL034C STU1 SGTC_2160 5660466 132.927 µM -0.883783369812804 0.173495051299796 no 2791 0.188406582680627 3853 2859134 SGTC_1624 st003710 6.25 µM -0.8847509948127 0.173232173900825 no 2792 0.188145472661208 3976 24207033 SGTC_32 0928-0142 34.1 µM -0.885007900234882 0.173162422316341 no 2793 0.188076185220572 3905 2244242 SGTC_275 trichlorophene 5.69 µM -0.885175967753781 0.17311680051187 no 2794 0.188030865902114 3980 62616 SGTC_3209 9113616 49.47 µM -0.886259818430642 0.172822773948538 no 2795 0.187738768071147 3970 16649353 SGTC_3106 9121286 49.47 µM -0.887042080212292 0.172610760165017 no 2796 0.18752812271306 3979 15943471 SGTC_2617 dihydrotanshinone i 20.83 µM -0.888130158881961 0.172316137738346 no 2797 0.18723537077343 3955 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_120 rhodamine 6G 52.259 µM -0.888649313032818 0.172175677888049 no 2798 0.187095789901951 3984 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2211 7117706 200 µM -0.890254225390851 0.171741922748246 no 2799 0.186664696986489 3885 822771 SGTC_2962 9082311 13.18 µM -0.891931706436158 0.171289301380782 no 2800 0.186214769389108 3954 16459453 SGTC_210 3551-0445 56.827 µM -0.893007498865813 0.170999430612167 no 2801 0.185926578441196 3994 2865180 YOR207C RET1 SGTC_1757 st041620 31.8375 µM -0.893609578646689 0.170837338093187 no 2802 0.185765409787701 4047 5289815 SGTC_2581 avocatin a 64 µM -0.894444033892629 0.170612847844041 no 2803 0.185542180685618 3949 6710728 A skin care supplement. SGTC_1250 0485-0349 40.2 µM -0.894580197081633 0.17057623432167 no 2804 0.185505770826611 3971 6842794 YDL195W SEC31 SGTC_1565 sinapyl alcohol 95.1 µM -0.894857474068825 0.17050169163949 no 2805 0.185431641032659 4008 5280507 A phenol propionate derived from cinnamic acid. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.89740046627001 0.169819011033195 no 2806 0.184752631920948 4004 6708784 An antioxidant flavonoid SGTC_2113 5491891 107.031 µM -0.897547132509706 0.169779691186809 no 2807 0.184713517493655 3977 789979 SGTC_3194 9111903 49.47 µM -0.905969633746274 0.167531495209405 no 2808 0.18247596268377 4009 17087251 SGTC_1443 4112-3303 14 µM -0.907498738041402 0.16712540180254 no 2809 0.182071558261501 3995 704433 SGTC_2933 9026794 32.47 µM -0.91033449169101 0.166373975043018 no 2810 0.181323066856682 3961 17586027 SGTC_932 2857-0803 154 µM -0.910678695963676 0.166282915431067 no 2811 0.181232346149581 4068 674898 SGTC_841 0251-0215 91.2 µM -0.911329723259555 0.166110773487405 no 2812 0.181060834927505 4015 3888614 SGTC_658 3253-0951 102 µM -0.911419016203711 0.166087171998252 no 2813 0.181037318897469 3992 1184878 SGTC_3229 9132204 49.47 µM -0.913188615920668 0.165619886724873 no 2814 0.180571675094798 4028 17682924 SGTC_3039 9090270 49.47 µM -0.91399765301141 0.165406533691098 no 2815 0.180359039470183 3988 17173750 SGTC_2838 9002687 71.43 µM -0.914568244670028 0.165256168626229 no 2816 0.180209167914869 3964 6457060 SGTC_2187 6125751 200 µM -0.916455368236493 0.164759495035508 no 2817 0.179714053174145 3993 874498 SGTC_2057 5236571 38.335 µM -0.918088993045122 0.164330321693301 no 2818 0.179286138440088 3985 54684039 YBR257W POP4 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.918496352606628 0.164223416329332 no 2819 0.179179533805399 4058 688664 SGTC_2923 7992654 58.14 µM -0.919211714484825 0.16403578957932 no 2820 0.178992422504082 4007 2985126 SGTC_195 4234-0266 16.654 µM -0.920360639919365 0.163734737943272 no 2821 0.178692164976342 3988 2303354 SGTC_490 phenamil 164 µM -0.922526314247263 0.163168244563432 no 2822 0.178127055510994 3975 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1791 st048313 56.1 µM -0.92416707483795 0.162739906282777 no 2823 0.177699667590716 4004 1204976 SGTC_2336 9001819 198.65 µM -0.924337844106519 0.162695367178571 no 2824 0.177655222544882 4047 2989602 SGTC_3224 9130643 49.47 µM -0.925116720495148 0.162492325473868 no 2825 0.177452598241203 4034 17644395 SGTC_1886 st057356 49.9 µM -0.926028331529475 0.162254891313105 no 2826 0.177215628463438 3964 24207747 SGTC_896 0964-0007 44.5 µM -0.929241262905152 0.161419867337573 no 2827 0.176382033816927 3936 6756758 SGTC_1366 1683-0113 21.9 µM -0.931339581402929 0.160876040821392 no 2828 0.175838966711543 4010 708623 SGTC_1921 5740136 50 µM -0.936937109755187 0.159431173282373 no 2829 0.174395454455206 3919 1774243 SGTC_3321 9137793 26.8275 µM -0.938592691739787 0.159005457573935 no 2830 0.173969953230277 3979 4904192 SGTC_2167 5876490 200 µM -0.941060776962651 0.158372199212242 no 2831 0.173336857142892 4166 686534 SGTC_2375 9072683 200 µM -0.94211263640274 0.158102817898319 no 2832 0.173067487797041 4028 16798029 SGTC_863 0466-0191 129 µM -0.94335926896996 0.157783944845763 no 2833 0.172748584736798 4057 765160 YPR165W RHO1 SGTC_219 mitoxanthrone 164.414 µM -0.944258294023771 0.157554247791708 no 2834 0.172518836322876 3982 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3294 9122953 26.2835 µM -0.945654919346554 0.157197852016697 no 2835 0.17216231142192 4032 16459826 SGTC_2252 omeprazole 400 µM -0.94586001452238 0.157145559780734 no 2836 0.172109995172604 3973 4594 A proton pump inhibitor. SGTC_398 bronopol 33.3 µM -0.947396627638838 0.156754140091483 no 2837 0.171718354461629 3937 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_394 menadione 8.33 µM -0.948591844709672 0.156450127844373 no 2838 0.171414120193962 4013 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1168 k815-0004 80.5 µM -0.948667595226141 0.156430873236019 no 2839 0.171394850038376 4018 642433 SGTC_973 1325-0077 65.9 µM -0.94926391331046 0.156279352910663 no 2840 0.171243201182871 4038 2835149 SGTC_1422 4031-0024 15.5 µM -0.951169644815519 0.155795768033649 no 2841 0.170759132552715 3981 782427 SGTC_862 0452-0056 10.2 µM -0.952603461649497 0.155432583972812 no 2842 0.170395511327491 3994 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1880 MG-132 525 µM -0.952982217653632 0.155336738886611 no 2843 0.170299540278037 3992 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2335 9018011 154.17 µM -0.954581269415188 0.154932525145027 no 2844 0.169894746505608 4046 6458208 SGTC_931 2812-0076 566 µM -0.954937323082737 0.154842615337337 no 2845 0.16980469693705 4007 3450959 SGTC_3198 9112019 49.47 µM -0.955296153708975 0.154752039176272 no 2846 0.169713976019112 4093 45595555 SGTC_1594 piperine 70.1 µM -0.955834608728025 0.1546161878479 no 2847 0.169577900117536 4011 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_417 st075190 100 µM -0.9573178663036 0.154242372063299 no 2848 0.169203420108 4041 222757 SGTC_387 norethindrone acetate 66.7 µM -0.95832176020016 0.153989706646618 no 2849 0.168950267201433 4044 541197 SGTC_2517 totarol 10 µM -0.959308863684071 0.153741534308143 no 2850 0.168701585705924 4058 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2365 9042475 200 µM -0.959674939238649 0.153649564868521 no 2851 0.168609419930971 4120 6464479 SGTC_1787 fluconazole 80 µM -0.95999110032296 0.153570164800543 no 2852 0.16852984702977 3836 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_864 0469-0573 172 µM -0.960201881359378 0.153517244767247 no 2853 0.168476810088102 4013 689425 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.960771554534467 0.153374279418067 no 2854 0.168333522041319 3998 6708514 SGTC_836 0330-0104 1.35 µM -0.961697761579841 0.153142026553781 no 2855 0.168100723551007 4035 46494820 SGTC_995 3931-2021 34.6 µM -0.965688210341916 0.152144060416332 no 2856 0.167100110332894 4049 730143 SGTC_1064 honokiol 6.76 µM -0.967102814238356 0.151791323084207 no 2857 0.16674631939872 4064 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1151 3909-8316 15.3 µM -0.969867724592976 0.151103451496557 no 2858 0.166056214867629 4096 800431 SGTC_797 k781-0471 270 µM -0.970851866370825 0.150859111880567 no 2859 0.165811025125629 4028 23738129 SGTC_2776 terbinafine 19.92 µM -0.972342952552501 0.150489411103114 no 2860 0.165439981066646 4088 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1380 2291-0730 164 µM -0.972810398904773 0.150373636546218 no 2861 0.165323771710491 4101 2999191 SGTC_975 1335-0046 28.5 µM -0.972971155681947 0.15033383490422 no 2862 0.165283819030387 4073 16486740 SGTC_2274 7947094 46.08 µM -0.973112138912035 0.150298934757289 no 2863 0.165248785788084 4015 2971028 SGTC_1509 1326-1131 80 µM -0.973911807930236 0.150101080291111 no 2864 0.165050165162919 3990 768313 SGTC_1889 st059080 5.18 µM -0.974669667803978 0.149913730586011 no 2865 0.164862071743718 3984 176925 Isolated from Daphnopsis sellowiana. SGTC_2135 5326629 150.42 µM -0.974786871430818 0.149884770735941 no 2866 0.164832995348348 4022 5020077 SGTC_2393 9031399 185.94 µM -0.978201769140845 0.149042621500525 no 2867 0.163987270825167 4117 1526623 YDL150W RPC53 SGTC_2456 5770359 74.46 µM -0.978206604247967 0.149041431358144 no 2868 0.163986075374746 4094 3118787 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.978583028010944 0.14894879563225 no 2869 0.163893024275512 4106 688788 SGTC_2062 5245942 200 µM -0.979494834627735 0.14872456473894 no 2870 0.163667769797734 4126 1376160 SGTC_825 1988-2224 89.6 µM -0.979661637157712 0.148683569194674 no 2871 0.163626584334327 4050 1180859 SGTC_933 2914-0560 114 µM -0.980396033637975 0.14850316427902 no 2872 0.163445333435381 4119 463887 SGTC_2364 9055074 200 µM -0.982378555431528 0.148016887838502 no 2873 0.162956693496851 4104 6470630 SGTC_2025 5147754 141 µM -0.983324938752853 0.147785133495528 no 2874 0.162723769926299 4043 315777 YLR208W SEC13 SGTC_1244 0416-0015 52.5 µM -0.98353940207641 0.147732648599467 no 2875 0.162671016391114 4045 96201 SGTC_2881 9058953 51.95 µM -0.98546716303888 0.147261434483947 no 2876 0.162197326632027 4018 17122249 SGTC_235 0330-0087 5 mM -0.987227122307006 0.146832117773633 no 2877 0.161765654189814 4099 46494818 YHR062C RPP1 SGTC_3265 9137266 49.47 µM -0.991380772829449 0.145822226536488 no 2878 0.160749842596095 3973 17224265 SGTC_1498 4478-3555 97.6 µM -0.994436351416371 0.145082300447441 no 2879 0.160005238994219 4034 3437919 SGTC_179 1273-0063 6.77 µM -0.996434909248245 0.144599707336078 no 2880 0.159519439228853 4061 3108139 SGTC_84 0443-0269 128.823 µM -0.997390883282445 0.144369250424302 no 2881 0.159287407399673 3982 6150058 SGTC_1413 3910-0535 34.4 µM -0.998749391159857 0.144042180621004 no 2882 0.158958053882372 4098 2876951 SGTC_2268 7933382 153.85 µM -0.998841450333111 0.1440200348557 no 2883 0.158935751424779 4095 935025 YOR257W CDC31 SGTC_2852 9023854 51.95 µM -1.00113949104535 0.14346796196797 no 2884 0.158379687549812 4166 19798528 SGTC_2903 5923464 63.88 µM -1.00412891399269 0.142751934664355 no 2885 0.157658240165392 4112 2876576 SGTC_3041 9091929 49.47 µM -1.00777160399331 0.141882707238596 no 2886 0.156782060462254 4103 25236887 SGTC_87 0100-0052 35.5 µM -1.00807962416959 0.14180937141235 no 2887 0.156708119295485 4144 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_966 1300-0360 30.2 µM -1.01014060418695 0.141319337913264 no 2888 0.15621396552551 4082 70588 SGTC_296 1222-0039 74.9 µM -1.01185680582737 0.140912158260064 no 2889 0.1558032622247 4103 5984176 SGTC_593 1203-0218 61.7 µM -1.01301006786043 0.140638987090467 no 2890 0.155527676017184 4130 3666956 SGTC_2947 9072639 7.68 µM -1.01559844998622 0.140027190840619 no 2891 0.154910321644081 4121 16488146 SGTC_1579 chlormadinone acetate 49.4 µM -1.01760207855759 0.139554851835794 no 2892 0.154433549579268 4135 45114258 A steroidal progestin. SGTC_323 4013-0906 34.3 µM -1.01787763832819 0.139489975738971 no 2893 0.154368054905987 4102 2910086 SGTC_3202 9113761 49.47 µM -1.01801681414282 0.139457216839491 no 2894 0.15433498276796 4110 4798415 SGTC_3078 9116413 49.47 µM -1.01801821675138 0.139456886723187 no 2895 0.15433464949206 4043 17177322 SGTC_324 1315-0088 19.6 µM -1.01864519335983 0.139309375466386 no 2896 0.154185720300361 4075 6787421 SGTC_320 4092-0846 5.34 µM -1.02099813525465 0.138756736574546 no 2897 0.153627661096494 4079 1359356 SGTC_638 3970-0837 4.09 µM -1.02206576760662 0.138506473338858 no 2898 0.153374886940631 4081 4118451 YLR208W SEC13 SGTC_1775 st081588 35.1725 µM -1.02537610248818 0.137732455379632 no 2899 0.1525928798184 4115 1426443 YGL099W LSG1 SGTC_2069 5228469 200 µM -1.02552704987289 0.137697231573278 no 2900 0.152557284385875 4134 2835210 SGTC_697 0508-1955 564 µM -1.02588295436479 0.137614205044926 no 2901 0.152473379109104 4113 6243113 SGTC_749 1000-0129 128 µM -1.02597476695375 0.137592792258551 no 2902 0.15245173905669 4172 708470 SGTC_2203 7227154 166.4 µM -1.02653035291799 0.137463265481706 no 2903 0.152320831989942 4102 896304 SGTC_2220 6782180 200 µM -1.0293135249122 0.136815662715526 no 2904 0.151666184904116 4032 833803 SGTC_2307 7538926 6.34 µM -1.02991001030535 0.136677141246489 no 2905 0.151526125587174 4105 96582 SGTC_1075 aripiprazole 15.2 µM -1.03061015573848 0.136514669240793 no 2906 0.151361835839378 4157 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2859 9028643 45.46 µM -1.03318319889404 0.13591871761936 no 2907 0.150759086938858 3992 17151580 SGTC_3046 9092212 49.47 µM -1.03553542370724 0.135375471256242 no 2908 0.150209466032853 4184 25236637 SGTC_1308 1187-1617 41.4 µM -1.03646340128234 0.13516156472938 no 2909 0.149993002596967 4131 2882570 SGTC_1364 1653-0028 37.6 µM -1.03697897945205 0.135042819885304 no 2910 0.149872826879384 4118 5718652 SGTC_2678 equilin 100 µM -1.03839091085564 0.134717998710564 no 2911 0.149544049689704 4144 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3145 9085516 49.47 µM -1.03889036520276 0.134603225466293 no 2912 0.149427863907941 4160 25236195 SGTC_486 niguldipine 82 µM -1.04117326491049 0.134079475925624 no 2913 0.148897570681022 4179 1236 A calcium channel blocker. SGTC_708 3448-5400 146 µM -1.04415488159742 0.133397535653824 no 2914 0.148206868827913 4079 3462195 SGTC_2403 6032726 181.2 µM -1.04480787674468 0.133248504954729 no 2915 0.148055886848132 4201 2881040 SGTC_2333 9017922 200 µM -1.04559360132324 0.133069333812511 no 2916 0.147874352387977 4175 3163164 SGTC_1261 0712-0010 12.7 µM -1.04694888186862 0.13276067495741 no 2917 0.147561577577898 4176 2840123 SGTC_901 1112-0062 60.1 µM -1.04725836600432 0.132690260590421 no 2918 0.147490216306803 4166 1908457 SGTC_1568 digitonin 820 nM -1.04762839606604 0.13260610447996 no 2919 0.147404924627852 4148 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_772 k072-0172 35.3 µM -1.04973879077509 0.132126839331235 no 2920 0.146919111946336 4175 5861980 SGTC_1870 st057514 26.5 µM -1.052906942576 0.131409604900622 no 2921 0.146191821948528 4142 5393161 SGTC_391 gliotoxin 8.33 µM -1.05434390678437 0.13108517985949 no 2922 0.145862746784394 4235 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2445 5742597 35.57 µM -1.05470305263667 0.131004181593321 no 2923 0.145780577615079 4139 1774255 SGTC_967 1306-0166 352 µM -1.06006597802516 0.129798792106794 no 2924 0.144557292191579 4168 4437607 SGTC_249 wiskostatin 11.211 µM -1.06128231056156 0.129526476902593 no 2925 0.144280811179308 4099 2775510 A n-wasp and actin depolymerizer. SGTC_2164 5685496 200 µM -1.06299701117049 0.129143258647145 no 2926 0.143891653376071 4088 759046 SGTC_26 0302-0163 425.158 µM -1.06355367460719 0.129019019177361 no 2927 0.14376546888442 4213 3100915 SGTC_1574 spiramycin 23.7 µM -1.06456716604718 0.128793034975454 no 2928 0.143535922366077 4120 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1181 1222-0449 220 µM -1.06676081884522 0.128304843982704 no 2929 0.143039927786081 4230 658318 SGTC_163 TUB2.036 7.546 µM -1.06678675980676 0.12829907859521 no 2930 0.143034069356639 4132 15992207 YJR013W GPI14 SGTC_2197 6588183 93.1375 µM -1.07202280742986 0.127139046063199 no 2931 0.14185489407698 4115 884136 SGTC_1849 st056239 19.2 µM -1.07317443965458 0.126884887170647 no 2932 0.141596428347037 4176 5393181 SGTC_1327 1436-0082 2.18 µM -1.07554175412599 0.126363545254338 no 2933 0.141066124414469 4175 15992205 SGTC_78 0336-0123 156.75 µM -1.07683834465287 0.1260786370397 no 2934 0.140776245762691 3991 6765896 SGTC_3184 9108758 49.47 µM -1.07818980119057 0.125782149749302 no 2935 0.140474531205059 4193 902885 SGTC_1289 0976-0073 69.1 µM -1.08076611196473 0.125218297669302 no 2936 0.139900583144598 4229 3391136 SGTC_460 trequinsin 123 µM -1.08080039564377 0.125210806252353 no 2937 0.139892956220304 4243 5537 A vasodilator. SGTC_3204 9114183 49.47 µM -1.0817440048396 0.125004738558495 no 2938 0.139683146971158 4154 17027248 SGTC_2360 9040895 200 µM -1.08221198297468 0.124902628268605 no 2939 0.139579172556745 4201 4914414 SGTC_2084 5306078 60.6385 µM -1.0840938118846 0.124492611776739 no 2940 0.13916160313917 4104 679340 SGTC_1450 4112-4260 37.6 µM -1.08461177680591 0.124379921928815 no 2941 0.139046818404939 4174 1633175 SGTC_1103 duloxetine 36.1 µM -1.08551202990512 0.124184230206702 no 2942 0.138847469266723 4264 60835 A selective serotonin reuptake inhibitor. SGTC_1170 0310-0127 64.8 µM -1.08689510966367 0.123884004281526 no 2943 0.138541583908841 4195 774975 SGTC_1640 st009078 66.4 µM -1.08758928936835 0.123733509924467 no 2944 0.138388230589216 4156 690618 SGTC_1916 st067606 49.2 µM -1.08774506076604 0.123699757129864 no 2945 0.138353834562401 4119 19590279 SGTC_216 k038-0035 28.382 µM -1.08809292102578 0.123624405488801 no 2946 0.13827704425327 4110 4444231 YPR107C YTH1 SGTC_1717 st033143 58.0435 µM -1.0899145069441 0.123230348094818 no 2947 0.137875402820502 4254 674616 SGTC_3022 9087993 49.47 µM -1.09076025999918 0.123047688783682 no 2948 0.137689193561924 4243 17173644 SGTC_2924 9010168 62.78 µM -1.0938991407788 0.122371436829391 no 2949 0.136999607825927 4260 2993929 SGTC_1676 st018489 23.4 µM -1.09489101211289 0.122158287823692 no 2950 0.136782193563176 4212 3696235 SGTC_2655 perillic acid 100 µM -1.09858846026453 0.121366019221777 no 2951 0.13597380670419 4207 5702197 An apoptosis inducer. SGTC_1760 st045453 10.4495 µM -1.09867110170921 0.121348352647291 no 2952 0.135955775946229 4238 3323419 YIL048W NEO1 SGTC_352 k048-0007 5.11 µM -1.09875103420861 0.121331266894651 no 2953 0.135938337784937 4162 6811911 SGTC_906 1165-0455 526 µM -1.09932753540791 0.121208088554321 no 2954 0.135812613007111 4168 3252859 SGTC_297 0986-0032 24 µM -1.10580167573764 0.119830826723608 no 2955 0.134406184777718 4137 2847425 SGTC_168 3970-0862 530.542 µM -1.11020853906287 0.118899676745699 no 2956 0.133454586999858 4165 3135186 SGTC_837 0091-0265 12.5 µM -1.1122707880657 0.118465692686122 no 2957 0.133010869930259 4152 759367 SGTC_406 estrone 100 µM -1.11350582797062 0.11820632491632 no 2958 0.132745623359491 4199 5870 A steroid. SGTC_653 0203-0016 55.2 µM -1.11722572638362 0.117427544900873 no 2959 0.13194891169474 4270 295302 SGTC_442 cape 100 µM -1.11842333765977 0.117177593636887 no 2960 0.13169311578775 4218 5281787 SGTC_1387 3342-1166 1.8 µM -1.12274401506964 0.116278966429155 no 2961 0.130773114329943 4191 3418228 SGTC_2598 perillyl alcohol 100 µM -1.12484168140531 0.115844455352581 no 2962 0.130328064136889 4260 10819 An apoptosis inducer. SGTC_732 3970-1727 52.7 µM -1.12726148077731 0.115344651237568 no 2963 0.12981597159114 4293 1275699 SGTC_2952 9073731 13.78 µM -1.13276730275274 0.114213151825237 no 2964 0.128655992909386 4277 16457353 SGTC_2862 9027634 71.43 µM -1.13280271178956 0.114205900600924 no 2965 0.12864855620646 4184 5012562 SGTC_4 0960-0234 25.671 µM -1.1328360874939 0.114199066071897 no 2966 0.128641546822682 4233 6821112 SGTC_2138 5575593 77.673 µM -1.13450969038752 0.11385672652442 no 2967 0.128290405632655 4223 762213 SGTC_37 0566-0070 1.56 µM -1.13495056727155 0.113766665911477 no 2968 0.128198015433949 4162 1626686 SGTC_2708 st078559 56 µM -1.13520564041842 0.11371458375391 no 2969 0.128144583388331 4162 17250902 SGTC_2012 4023501 200 µM -1.13520986920578 0.113713720441425 no 2970 0.128143697683545 4249 3477460 SGTC_579 4491-1009 110 µM -1.13549232500595 0.113656067296494 no 2971 0.128084547926103 4339 1271041 SGTC_2826 7992541 19.48 µM -1.13680732652935 0.11338793158593 no 2972 0.127809419944366 4245 2985066 SGTC_958 1222-0007 33 µM -1.14771384976315 0.111181412061505 no 2973 0.12554335590384 4315 7312461 SGTC_964 1287-0107 19.4 µM -1.14785821427542 0.111152413035911 no 2974 0.125513550297269 4267 51516812 YPR165W RHO1 SGTC_3013 9080133 71.4286 µM -1.15083862546529 0.110554936688545 no 2975 0.124899315510683 4328 17050193 SGTC_588 3970-1144 52.9 µM -1.1550378366389 0.109717042243907 no 2976 0.124037466238404 4118 1888707 SGTC_1671 st016596 74.5 µM -1.15711944141774 0.109303381022518 no 2977 0.123611782351518 4313 2829167 SGTC_273 hydroxyurea 18.1 mM -1.15890789611283 0.108948871088871 no 2978 0.123246864993753 4321 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3185 9108267 49.47 µM -1.16048926119373 0.108636099905494 no 2979 0.122924831733046 4261 4910486 SGTC_2919 7978188 46.38 µM -1.16095717343193 0.108543677556779 no 2980 0.12282965809145 4272 2980291 SGTC_1299 1079-1439 3.74 µM -1.16771025943539 0.107216097818358 no 2981 0.121461828522791 4225 323161 SGTC_3135 9127742 49.47 µM -1.16847321088886 0.107066849555288 no 2982 0.121307969502856 4355 3643468 SGTC_3256 9138902 49.47 µM -1.16869307756502 0.107023867148599 no 2983 0.121263655995802 4357 17228773 SGTC_503 tyrphostin 8 294 µM -1.16920368046023 0.106924095850143 no 2984 0.121160789345788 4255 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1496 4469-0713 57.4 µM -1.17005401503821 0.106758090267931 no 2985 0.12098961620725 4233 746691 SGTC_1672 st016598 6.51 µM -1.17223387303527 0.106333379727008 no 2986 0.120551586169995 4252 4665860 YNL267W PIK1 SGTC_2295 7971645 200 µM -1.174322982007 0.105927496511632 no 2987 0.120132840674617 4312 2978226 YKL099C UTP11 SGTC_2466 5983409 37.09 µM -1.17591174906254 0.105619572767923 no 2988 0.119815071690701 4270 2879657 SGTC_729 4092-0585 94.1 µM -1.17626829561419 0.105550558416148 no 2989 0.119743840384936 4278 2169061 SGTC_1704 st028805 70.8 µM -1.17893339831361 0.105035724884914 no 2990 0.119212348687799 4302 2876101 SGTC_1291 0993-0025 5.79 µM -1.18154685716743 0.104532635223943 no 2991 0.118692775306958 4268 4353356 SGTC_1697 st025554 27.742 µM -1.18206818251271 0.10443248951962 no 2992 0.118589323975539 4261 1269519 SGTC_2512 diallyl trisulfide 49.23 µM -1.18235302051209 0.104377802005675 no 2993 0.118532827903719 4298 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1814 st052110 31.539 µM -1.18365753364206 0.104127606972127 no 2994 0.118274327844772 4213 674163 SGTC_725 1497-0963 19 µM -1.18788471000791 0.103319856501447 no 2995 0.117439417192562 4387 3549977 SGTC_1204 4049-0315 18.3 µM -1.18871261258767 0.103162190806972 no 2996 0.11727638786399 4327 588402 SGTC_1233 0325-0408 14.2 µM -1.18925192092111 0.103059578998688 no 2997 0.117170274339048 4295 12874 SGTC_2608 thymoquinone 42.66 µM -1.1921196976682 0.102515184856792 no 2998 0.116607157228755 4262 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1491 4138-0063 26.5 µM -1.19743216303816 0.101512241390951 no 2999 0.115569076844474 4269 23883227 SGTC_3002 9075603 71.4286 µM -1.19842305152774 0.101325964444679 no 3000 0.115376181417422 4220 20105405 SGTC_2255 7941087 197.44 µM -1.20021502031552 0.100989725194632 no 3001 0.115027921661523 4400 935561 SGTC_2580 diallyl disulphide 81.36 µM -1.20336832003863 0.100400026432019 no 3002 0.114416910787376 4266 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.20799791432553 0.0995388044196673 no 3003 0.113524032300549 4313 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_308 4092-1169 104 µM -1.20886077803571 0.0993788885616344 no 3004 0.113358168413959 4238 2268590 YDL196W YDL196W SGTC_1737 st035557 69.7 µM -1.20971676468855 0.0992204328931702 no 3005 0.113193797326817 4150 5716916 SGTC_799 1310-0557 151 µM -1.20993399955935 0.0991802489445166 no 3006 0.113152109804367 4337 5354492 SGTC_1122 capsaicin 818.572 nM -1.21289699008908 0.0986333448467197 no 3007 0.112584603284149 4350 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3098 9119039 49.47 µM -1.21556140511375 0.0981434392614987 no 3008 0.112076021953732 4299 17161528 SGTC_1656 st012921 11 µM -1.21939306291783 0.0974420416037122 no 3009 0.11134752081433 4200 6732821 SGTC_2262 9014885 67.46 µM -1.22500445525332 0.0964215032550375 no 3010 0.110286770938392 4304 6457424 SGTC_1381 2324-0066 62.1 µM -1.22590229537895 0.0962589455104818 no 3011 0.110117722462272 4334 10885928 SGTC_3071 9117417 49.47 µM -1.22818748597274 0.0958461110917021 no 3012 0.109688297633558 4255 45595590 YGL055W OLE1 SGTC_2484 5809818 12.04 µM -1.22866005674589 0.0957609008814905 no 3013 0.109599644045097 4269 2870548 SGTC_1766 st045414 44.774 µM -1.22872038847791 0.0957500263553682 no 3014 0.109588329604527 4311 253960 SGTC_609 0986-0026 86.3 µM -1.22931985729798 0.0956420241255672 no 3015 0.109475952501563 4274 2848610 SGTC_2799 7812892 81.82 µM -1.23338564707138 0.0949118831524435 no 3016 0.108715958674079 4335 20205235 SGTC_1460 k062-0059 9.15 µM -1.23465981627183 0.0946839131303121 no 3017 0.108478568500679 4197 1373085 SGTC_2864 9034755 47.6 µM -1.23585272792307 0.09447084746169 no 3018 0.108256655629538 4245 4930451 SGTC_1059 3448-6867 171 µM -1.23746902182185 0.0941827258532281 no 3019 0.107956504067074 4279 3934407 SGTC_726 3448-4391 34.2 µM -1.24116754937978 0.0935258636378804 no 3020 0.107271929943271 4415 1356692 SGTC_2775 cyproheptadine 69.59 µM -1.24247434597454 0.0932945860163209 no 3021 0.107030800006176 4328 2913 A selective serotonin reuptake inhibitor. SGTC_108 0509-0257 621.132 µM -1.24272630239549 0.0932500432526253 no 3022 0.106984354030432 4268 536624 SGTC_2813 7971799 71.43 µM -1.24486592966675 0.0928724168952099 no 3023 0.106590518218071 4328 2234054 SGTC_2802 7925815 54.55 µM -1.24502823927212 0.0928438168105117 no 3024 0.10656068505882 4290 1262923 SGTC_3138 9097216 49.47 µM -1.24838968973115 0.0922529689819793 no 3025 0.105944191453058 4268 25237486 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.24979488903764 0.0920068013090516 no 3026 0.105687241799269 4351 165521 SGTC_2833 9001315 45.46 µM -1.2517292158467 0.0916687353371923 no 3027 0.105334275232229 4279 2989378 SGTC_311 1315-0136 58 µM -1.25231624386741 0.0915663215942485 no 3028 0.105227326073333 4344 6759207 SGTC_443 clozapine 122 µM -1.2530186872694 0.0914438837837447 no 3029 0.105099452966383 4295 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_140 0062-0056 502.533 µM -1.25482843286728 0.0911289992847731 no 3030 0.104770524283349 4243 3758964 SGTC_619 1652-1634 108 µM -1.2559643961403 0.0909317599364925 no 3031 0.104564439493016 4303 5400454 SGTC_2459 5811157 9.22 µM -1.25617456224791 0.0908953031604581 no 3032 0.104526343679058 4288 2870684 YBR192W RIM2 SGTC_620 0109-0052 432 µM -1.25739715396809 0.0906834394767119 no 3033 0.104304929645991 4366 493037 SGTC_2075 5212009 200 µM -1.25788961928686 0.0905982034811499 no 3034 0.104215839202913 4254 780898 SGTC_1821 st053465 65.6 µM -1.25892162274706 0.0904197770342689 no 3035 0.104029321447444 4348 675086 SGTC_1272 0839-0021 27 µM -1.25937280630549 0.0903418524604638 no 3036 0.103947853482264 4348 5027250 SGTC_739 1486-1183 203 µM -1.26268104746096 0.089772004199461 no 3037 0.103351913932743 4340 4346692 SGTC_1414 3917-0015 5.4 µM -1.26540073624718 0.089305539466049 no 3038 0.102863855714309 4342 6618702 SGTC_606 k015-0008 38.6 µM -1.26728591718634 0.0889832642856319 no 3039 0.102526537098959 4414 1970475 SGTC_3103 9120822 49.47 µM -1.27584746019753 0.0875305406129843 no 3040 0.101004723377721 4350 17141819 SGTC_1184 1269-1718 139 µM -1.27641969894411 0.0874340778325845 no 3041 0.100903598181846 4391 5403821 SGTC_2907 7721985 69.9 µM -1.28026650499592 0.0867876770509436 no 3042 0.100225711728705 4351 3267881 SGTC_1963 st076565 50.3 µM -1.28291365977292 0.0863449390918178 no 3043 0.0997611633254588 4370 4914280 SGTC_1034 k072-0165 12.7 µM -1.28325812747234 0.0862874511120796 no 3044 0.0997008286438119 4378 5835461 SGTC_1441 4106-0040 13 µM -1.28358540128931 0.0862328591299315 no 3045 0.0996435302301633 4361 2904180 SGTC_1088 bifonazole 369 nM -1.28367046618554 0.0862186738318505 no 3046 0.0996286411870477 4334 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_23 0213-0011 39.996 µM -1.28687244158316 0.0856859855985352 no 3047 0.099069376087137 4353 627608 SGTC_3127 9126946 49.47 µM -1.28944765199867 0.0852593582084561 no 3048 0.09862125206894 4329 27243249 SGTC_2869 9037858 32.47 µM -1.28959802382083 0.0852344958254165 no 3049 0.0985951311121595 4326 27187042 SGTC_602 3130-1533 38.1 µM -1.29152349960121 0.0849166188156273 no 3050 0.098261105923728 4403 720941 SGTC_1499 4480-0877 67.3 µM -1.29201423351864 0.0848357457944463 no 3051 0.0981761077192568 4348 2861909 SGTC_803 4488-1585 147 µM -1.29381678736228 0.0845391802681328 no 3052 0.0978643563304232 4365 747204 SGTC_3174 9107204 49.47 µM -1.30018161405202 0.0834982260502378 no 3053 0.0967693653151384 4394 3938802 SGTC_38 0929-0051 58.268 µM -1.30048397615964 0.0834490160966697 no 3054 0.0967175723614207 4330 1379719 SGTC_3279 9140807 49.47 µM -1.30491504208219 0.082730350799708 no 3055 0.0959608893064196 4416 45595718 SGTC_2184 6075246 200 µM -1.30606405020903 0.0825447582326819 no 3056 0.0957653885245437 4353 2267320 SGTC_3334 9142812 21.919 µM -1.30643366312745 0.0824851234917537 no 3057 0.0957025621649216 4374 45283678 SGTC_1167 k781-0610 148 µM -1.30651266450221 0.0824723813205192 no 3058 0.0956891375405867 4395 4525169 SGTC_1354 1498-1681 81 µM -1.31434243226123 0.0812168525044252 no 3059 0.0943654969436232 4359 5754243 SGTC_2871 9038510 12.99 µM -1.31737737068584 0.0807340876019344 no 3060 0.0938560811725141 4360 4945164 SGTC_2842 9000675 19.48 µM -1.31792333788575 0.080647471542043 no 3061 0.0937646561556604 4401 2989072 SGTC_723 4182-0001 115 µM -1.32265120049045 0.0799003434128385 no 3062 0.0929756994703738 4397 744821 YLR208W SEC13 SGTC_2645 abamectin 100 µM -1.32369408439978 0.0797362468594525 no 3063 0.0928023319521132 4332 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1610 st001799 48.1 µM -1.33142119169044 0.0785283286897654 no 3064 0.0915252301464573 4342 621897 SGTC_464 bw-b 70c 158 µM -1.33178385403011 0.0784719791984669 no 3065 0.091465612534133 4394 5353454 SGTC_1183 1254-0324 198 µM -1.33221161393793 0.0784055544307606 no 3066 0.0913953306152621 4459 5799357 SGTC_2083 5306046 65.942 µM -1.33260507684848 0.0783444931268928 no 3067 0.0913307191238568 4378 539837 SGTC_1837 st055472 66.5 µM -1.33312907467455 0.0782632301737871 no 3068 0.0912447247657715 4447 676091 SGTC_3282 9108498 15.4605 µM -1.33569477024255 0.0778662579288717 no 3069 0.0908245297238677 4345 16459645 SGTC_3339 9145883 14.936 µM -1.33704608495757 0.0776577936931955 no 3070 0.0906037971651355 4309 2030670 SGTC_2700 st077718 96.8 µM -1.33935826352408 0.077302082306679 no 3071 0.0902270348311452 4373 904970 SGTC_600 1495-0418 41.6 µM -1.34047213399512 0.0771311640380141 no 3072 0.0900459489721378 4373 5377768 SGTC_1208 2323-2347 50.3 µM -1.34174213050414 0.0769366394834929 no 3073 0.0898398107796852 4406 5412760 SGTC_1382 3002-2117 298 µM -1.34599071702728 0.0762885962491331 no 3074 0.0891527551839547 4472 1497314 SGTC_2596 sinensetin 100 µM -1.34632337997536 0.0762380305635027 no 3075 0.0890991244724199 4403 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2036 5160441 105 µM -1.34960880104763 0.0757400066095058 no 3076 0.088570749795905 4368 134534 YIL048W NEO1 SGTC_2243 6634756 200 µM -1.35269662344228 0.0752741985434753 no 3077 0.0880762847990196 4445 885676 SGTC_3232 9132874 49.47 µM -1.35530371278154 0.0748826137072912 no 3078 0.0876604062960183 4373 3784940 SGTC_353 1988-1175 58.3 µM -1.35704909528978 0.0746213269444445 no 3079 0.0873828057024266 4230 2788357 SGTC_1868 st057644 42.7 µM -1.3660305895924 0.0732877726552014 no 3080 0.0859646811838343 4431 688665 SGTC_536 3852-0578 10.6 µM -1.36833222491382 0.0729489827735279 no 3081 0.0856040541355495 4443 2869208 SGTC_7 0192-1582 4.227 µM -1.36993096024212 0.0727143628976001 no 3082 0.0853542270359735 4466 252616 SGTC_2009 4012297 12.05 µM -1.37046423589293 0.0726362315224422 no 3083 0.0852710160645426 4383 45595307 SGTC_676 falcarinol 140 µM -1.37076193926891 0.0725926423275705 no 3084 0.0852245896321673 4439 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1570 verbenone 133 µM -1.37147288259235 0.0724886283339089 no 3085 0.085113795621134 4433 29025 A natural terpanoid with antifungal properties. SGTC_3307 9126885 69.2785 µM -1.37485957257117 0.0719947080740723 no 3086 0.0845874924268396 4388 24824909 SGTC_123 0083-0120 66.675 µM -1.37823243103977 0.0715053736809447 no 3087 0.0840657686328696 4404 16001701 SGTC_549 1661-1316 519 µM -1.38034436073355 0.0712002767413599 no 3088 0.0837403212656464 4437 2857282 SGTC_3231 9132313 49.47 µM -1.38390695281461 0.0706878783118567 no 3089 0.0831934737743694 4375 4905967 SGTC_1045 1348-1485 165 µM -1.38628188021466 0.0703478759630974 no 3090 0.0828304237768769 4395 6810614 SGTC_1773 st048542 73.5835 µM -1.38821251146336 0.0700724082699521 no 3091 0.0825361717838167 4403 3237138 SGTC_3117 9124945 49.47 µM -1.38892779231481 0.069970560997652 no 3092 0.0824273541694547 4332 17592065 SGTC_2282 7944268 200 µM -1.39097129416288 0.0696802187540496 no 3093 0.0821170658369833 4430 2970414 SGTC_1298 1079-1278 263 µM -1.40451969577098 0.0677786563519656 no 3094 0.080082075431112 4419 2840950 SGTC_214 4373-3496 70 µM -1.40681483738071 0.0674605338770696 no 3095 0.0797411508534275 4527 3779166 SGTC_626 0214-0009 33 µM -1.41166982283484 0.0667914027827213 no 3096 0.0790236014162098 4499 3437874 SGTC_206 4546-0025 72.014 µM -1.4139804934055 0.0664747471670209 no 3097 0.0786838149851179 4485 6620745 YIL048W NEO1 SGTC_1695 st026914 34.495 µM -1.41541105355852 0.0662792856791623 no 3098 0.0784740053021168 4442 3289191 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.41953778742662 0.06571793191557 no 3099 0.077871144179973 4440 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2845 9003024 42.97 µM -1.42107639170559 0.0655095835315028 no 3100 0.0776472762174798 4486 2990173 SGTC_2652 actinonin 100 µM -1.42216494629451 0.0653624877923741 no 3101 0.0774891861553759 4499 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3210 9128157 49.47 µM -1.42587637857824 0.0648628895096332 no 3102 0.0769520144597254 4407 17590849 SGTC_429 1112-0049 25.5 µM -1.43227568418608 0.0640084440350585 no 3103 0.0760324695740675 4416 2836170 SGTC_121 0557-0495 61.343 µM -1.43292098303843 0.0639227707545379 no 3104 0.0759402100020919 4500 3104427 SGTC_473 2-arachidonoylglycerol 10 µM -1.43947446565484 0.0630577397814616 no 3105 0.0750080697380951 4300 5282280 An endocannabinoid. SGTC_978 1416-0512 87.4 µM -1.44228678580841 0.062689333294134 no 3106 0.0746107432099344 4506 6814003 SGTC_584 0986-0246 15.4 µM -1.44248729096716 0.0626631318466499 no 3107 0.0745824771649555 4536 53315 YDR232W HEM1 SGTC_2079 5212404 121 µM -1.44415854757215 0.0624450687094036 no 3108 0.0743471910818308 4415 758462 SGTC_1902 st060212 70.5 µM -1.44518589887333 0.0623113153353301 no 3109 0.0742028380635745 4465 688944 SGTC_2377 9073351 62.6 µM -1.44555636238061 0.0622631386359032 no 3110 0.0741508368235762 4458 7337946 YHR072W ERG7 SGTC_1437 4092-1038 11.6 µM -1.44694938717035 0.0620822435539568 no 3111 0.0739555497524311 4527 3977136 SGTC_3112 9123419 49.47 µM -1.45691043552539 0.0608006489244817 no 3112 0.0725705525263616 4522 17015854 SGTC_1293 1000-1278 195 µM -1.4576858486577 0.060701758220664 no 3113 0.0724635771673062 4480 678847 SGTC_1573 oleylamine 1.06 µM -1.45905259941926 0.0605277588374211 no 3114 0.0722753155357339 4463 5356789 An amine of the fatty acid oleic acid. SGTC_2473 5854593 8.94 µM -1.46086257540395 0.0602979338322301 no 3115 0.0720265794596908 4403 2872951 SGTC_1206 3978-0017 132 µM -1.4615817905995 0.060206800018364 no 3116 0.0719279236652052 4513 3873677 SGTC_2556 citropten 84.59 µM -1.4627854787726 0.0600545185264621 no 3117 0.0717630438782267 4479 2775 A potential DNA crosslinker. SGTC_258 haloperidol 50.781 µM -1.46308945471941 0.0600161095364627 no 3118 0.071721451495985 4473 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_644 1498-1197 63.3 µM -1.47071146381347 0.0590593023341556 no 3119 0.07068458231307 4508 6741615 SGTC_373 0844-0104 25.9 µM -1.47181665753466 0.0589215638330936 no 3120 0.0705351970734898 4494 5375804 SGTC_2720 fluspirilene 36.88 µM -1.47317336887752 0.0587528238586205 no 3121 0.0703521470085161 4467 3396 An atypical antipsychotic. SGTC_512 prima-1 270 µM -1.47734702218163 0.0582361061049057 no 3122 0.0697913197047352 4486 322968 A re-activator of the apoptotic function of mutant p53. SGTC_14 0354-0009 295 µM -1.47939700353659 0.057983619618338 no 3123 0.0695171202586156 4577 1713507 SGTC_874 0599-0792 117 µM -1.48555797037129 0.0572299785799913 no 3124 0.0686980395622793 4489 765305 SGTC_565 1418-0001 44.5 µM -1.48623096155764 0.0571481240465833 no 3125 0.0686090203209491 4522 2862145 SGTC_2331 7980721 200 µM -1.49259994561134 0.0563780329803917 no 3126 0.0677709688029169 4450 2981221 SGTC_1501 4491-0275 38.4 µM -1.49347513472874 0.0562728537345629 no 3127 0.067656429163939 4495 5104718 SGTC_496 calpeptin 138 µM -1.49484926787088 0.0561080241470755 no 3128 0.0674768924734152 4486 73364 A calpain inhibitor. SGTC_1642 st009582 77.7 µM -1.49836861837327 0.0556876082099593 no 3129 0.0670187525360565 4482 6739311 SGTC_670 4204-0025 119 µM -1.50172649568096 0.0552888030092393 no 3130 0.0665838791087235 4501 719039 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.50329372396251 0.0551034416151923 no 3131 0.0663816589107201 4496 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2381 9035592 200 µM -1.50885501639419 0.0544496481804237 no 3132 0.0656679187975851 4513 4749657 SGTC_1925 st057770 10.1 µM -1.51117150026341 0.0541791357262531 no 3133 0.0653723807827846 4495 5989122 SGTC_610 4215-0184 155 µM -1.51435169555317 0.0538094950339902 no 3134 0.064968331818453 4514 5605015 SGTC_2111 5486399 200 µM -1.5246295258092 0.0526285233693147 no 3135 0.0636757643283851 4472 689674 SGTC_1013 4112-3890 241 µM -1.52638332517821 0.0524290734778089 no 3136 0.0634572139634009 4484 705171 SGTC_2659 sanguinarine 24.21 µM -1.53010319753592 0.0520080193277957 no 3137 0.0629955934573322 4472 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1255 0566-0045 221 µM -1.53602864838634 0.0513428675700553 no 3138 0.0622656771090797 4522 2788469 SGTC_1006 4099-6547 255 µM -1.54007007191371 0.0508930986188559 no 3139 0.0617716369803336 4519 3146833 SGTC_2095 5432005 200 µM -1.54280490245038 0.0505905235734051 no 3140 0.0614390598233972 4535 783734 SGTC_1825 st052143 62.6 µM -1.54874226528558 0.0499385606782417 no 3141 0.0607218446714985 4557 674173 SGTC_454 lyso-paf C-16 6.67 µM -1.55010303628815 0.0497900866414222 no 3142 0.0605583937074586 4533 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3218 9131285 49.47 µM -1.55789229633275 0.0489469637844882 no 3143 0.0596293908480522 4507 17156417 SGTC_3227 9130768 49.47 µM -1.56192380555404 0.0485150877660622 no 3144 0.0591529698299154 4607 17720899 SGTC_1258 0671-0043 57.1 µM -1.56311015296471 0.0483885820173248 no 3145 0.0590133439779586 4527 4298767 SGTC_64 000l-0018 272.079 µM -1.5659903435018 0.0480825515547464 no 3146 0.0586754389217419 4443 6811119 SGTC_1224 0823-0416 294 µM -1.57396497606308 0.0472432945166133 no 3147 0.0577477733663628 4558 3598164 SGTC_2325 6158266 200 µM -1.57493733784027 0.047141770375081 no 3148 0.0576354545686379 4505 3623240 SGTC_992 3909-8734 162 µM -1.57500775048045 0.0471344253986921 no 3149 0.0576273277868204 4545 4288319 SGTC_290 2043-6722 48.1 µM -1.5772083853045 0.0469053319065643 no 3150 0.0573737920974648 4554 773758 YLR208W SEC13 SGTC_1235 benzylparaben 21.5 µM -1.58188710877954 0.0464212287918408 no 3151 0.0568376721719216 4575 7180 SGTC_2620 irigenin 100 µM -1.58199559209515 0.0464100518822198 no 3152 0.0568252883784792 4516 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2680 butyl paraben 22.24 µM -1.5831203970402 0.0462942918158709 no 3153 0.0566970127161134 4614 7184 An antifungal and steroid mimetic. SGTC_2807 7945238 51.95 µM -1.58404652518114 0.0461991528363904 no 3154 0.0565915659923079 4500 17148797 SGTC_1994 st072947 40.9 µM -1.5863709826418 0.0459610582652881 no 3155 0.0563275894217847 4583 5286565 YDL195W SEC31 SGTC_3344 9148862 3.898 µM -1.59720006722019 0.044864798791224 no 3156 0.055110558875449 4567 4905352 SGTC_1292 0kpi-0043 232 µM -1.59902717044431 0.0446819284895244 no 3157 0.0549072827725712 4558 3333905 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.60074330887522 0.0445107115734728 no 3158 0.0547168922745752 4583 1273210 SGTC_1936 st074407 74.3 µM -1.60167399745436 0.0444180792604488 no 3159 0.0546138590332358 4573 809813 SGTC_1009 4106-0057 9.87 µM -1.60253971785939 0.0443320528010985 no 3160 0.0545181559684821 4545 2928005 SGTC_2685 mycophenolic acid 18.85 µM -1.60352799295536 0.0442340122918499 no 3161 0.0544090669910338 4552 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3077 9117319 49.47 µM -1.60817428441884 0.0437754230689668 no 3162 0.053898506771396 4506 17154678 SGTC_1358 1509-0022 2.48 µM -1.61140012611339 0.0434592940616881 no 3163 0.0535462698858955 4579 3258434 SGTC_733 4069-0007 56.1 µM -1.61253214043191 0.0433487956823895 no 3164 0.0534230958782071 4553 5717425 YNL287W SEC21 SGTC_2636 apigenin dimethyl ether 100 µM -1.61456719469144 0.0431507201433479 no 3165 0.0532022272153067 4519 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2151 5563267 85.4165 µM -1.6172577276243 0.042889968526985 no 3166 0.0529113300034308 4604 5310824 SGTC_1802 st050112 57.9 µM -1.61739374554858 0.042876820307072 no 3167 0.0528966574758665 4561 4662563 SGTC_1347 1493-0251 600 nM -1.61934061781489 0.0426889819661712 no 3168 0.0526869979409044 4589 3986378 SGTC_440 fluspirilene 35.1 µM -1.62253251923655 0.0423824605103704 no 3169 0.0523446880114308 4570 3396 An atypical antipsychotic. SGTC_3350 9150499 3.57 µM -1.6258058876441 0.0420699672596912 no 3170 0.0519954777443983 4558 4910996 YPR165W RHO1 SGTC_1150 3909-7983 10.9 µM -1.63360068635087 0.0413333386820954 no 3171 0.0511713618117922 4559 23965914 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.63661753584078 0.0410510595912596 no 3172 0.0508552046145751 4578 390807 SGTC_1436 4092-1007 8.32 µM -1.63852156469305 0.0408737104841361 no 3173 0.0506564696553976 4571 2881121 SGTC_3221 9128209 49.47 µM -1.63988917270009 0.0407467097935668 no 3174 0.0505141062487109 4586 16460723 SGTC_970 1315-0089 19.5 µM -1.6407559104651 0.0406663875081846 no 3175 0.0504240468923534 4543 6811083 YLR033W RSC58 SGTC_2560 caryophyllene 100 µM -1.64114785290777 0.0406301076520343 no 3176 0.0503833637042775 4588 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1392 3455-1037 33.9 µM -1.64304735972414 0.0404546532328442 no 3177 0.0501865674387148 4576 981132 SGTC_1985 st071382 65.5 µM -1.64515015110463 0.0402611397032475 no 3178 0.0499694252488778 4554 6123237 SGTC_141 0443-0274 32.331 µM -1.6547331089532 0.0393887485610904 no 3179 0.0489893239412358 4508 1627241 SGTC_1048 3161-0300 24.5 µM -1.65802428999512 0.0390927055055946 no 3180 0.0486562818725677 4576 2165101 SGTC_806 3966-4455 5.86 µM -1.67077805199651 0.0379625647809648 no 3181 0.0473827626338597 4562 714982 SGTC_2378 9074213 121.43 µM -1.67586404665489 0.0375193818356666 no 3182 0.04688241274295 4563 657714 SGTC_3338 9144300 39.5675 µM -1.68168453761467 0.0370173900821752 no 3183 0.0463150139664711 4568 4901274 SGTC_3029 9088683 49.47 µM -1.68386156394459 0.0368310475614792 no 3184 0.0461042129973395 4585 25236615 SGTC_1188 1403-0014 4.57 µM -1.68989492497622 0.0363186276299286 no 3185 0.0455240293541405 4614 9614867 SGTC_3306 9127676 59.7925 µM -1.69581996900524 0.0358211011745825 no 3186 0.0449599897748588 4544 41905287 SGTC_1210 3013-0140 750 nM -1.70814343299338 0.0348041792886695 no 3187 0.0438048657718957 4619 905973 SGTC_828 2074-0507 139 µM -1.72753096600837 0.0332524077404289 no 3188 0.0420361744086058 4624 X828 SGTC_1394 3474-0001 65.7 µM -1.73068843705812 0.0330051640856508 no 3189 0.0417536743384695 4596 5017666 YIL048W NEO1 SGTC_3169 9102970 49.47 µM -1.73795514936286 0.0324419009324661 no 3190 0.0411093584706249 4653 17027839 SGTC_2055 5235184 200 µM -1.74128012611464 0.0321868300119951 no 3191 0.0408172440436995 4599 2836034 SGTC_2424 5537928 59.2 µM -1.74307212609537 0.0320500472027223 no 3192 0.040660508414635 4605 5382802 SGTC_2870 9038528 12.99 µM -1.74463104007199 0.0319314464825444 no 3193 0.0405245570524844 4617 6463316 SGTC_3068 9116768 49.47 µM -1.74924891631985 0.0315822482810755 no 3194 0.0401240009499426 4569 41904888 SGTC_39 0986-0283 58.349 µM -1.75045934799759 0.0314912408058103 no 3195 0.0400195414762958 4617 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2985 9022375 71.43 µM -1.75451278879623 0.0311880561623622 no 3196 0.0396713402482735 4612 4939335 SGTC_1914 st062367 72.6 µM -1.75702029028425 0.0310017146122562 no 3197 0.0394571753962535 4576 978205 SGTC_581 0958-0271 211 µM -1.75816451854944 0.0309169894871159 no 3198 0.0393597602469768 4622 4591145 SGTC_2011 4012611 177 µM -1.75930314411156 0.0308328695414623 no 3199 0.0392630164320096 4586 2049887 SGTC_2972 9093619 59.92 µM -1.76467659916469 0.030438439693438 no 3200 0.03880906681114 4579 25236256 SGTC_3151 9099821 49.47 µM -1.77614280093588 0.029610749235236 no 3201 0.0378546915816356 4562 17174189 SGTC_3291 9121177 71.43 µM -1.7792675145413 0.0293884579321575 no 3202 0.037597957090252 4596 17015612 SGTC_1956 st077085 54 µM -1.77930687682361 0.0293856665715475 no 3203 0.0375947320737707 4628 24208685 SGTC_667 1498-1044 59 µM -1.78778707875353 0.0287894083431721 no 3204 0.0369051831624806 4612 6739982 SGTC_1116 jasmonic acid  1.58368 µM -1.79069865137926 0.0285870243371964 no 3205 0.0366708331295993 4659 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1305 1181-0477 144 µM -1.79866507377866 0.0280393174550939 no 3206 0.0360358384417966 4651 6252086 SGTC_52 0329-0193 875 nM -1.80018417794408 0.0279358745078344 no 3207 0.0359157806451992 4643 3739292 SGTC_765 1319-0117 244 µM -1.80359677051453 0.0277046537687165 no 3208 0.0356472713633888 4591 3487746 YGL099W LSG1 SGTC_756 0508-1999 28.3 µM -1.81112577242418 0.0272001622318933 no 3209 0.0350606924546145 4645 6753853 SGTC_2249 haloperidol 116.36 µM -1.81358467084912 0.0270370697041635 no 3210 0.0348708461063689 4552 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3088 9117578 49.47 µM -1.81390607340164 0.0270158123183525 no 3211 0.0348460937736873 4681 678341 SGTC_682 0kpi-0099 17 µM -1.82116902198396 0.02653915178963 no 3212 0.0342905839312204 4630 1714895 YML126C ERG13 SGTC_2467 5474540 200 µM -1.82253826014401 0.0264500817981449 no 3213 0.0341866769508051 4625 5413519 SGTC_1456 k015-0012 13 µM -1.82268674403641 0.0264404378383693 no 3214 0.0341754245694055 4625 2989616 SGTC_704 1310-0270 142 µM -1.82536958378887 0.0262666942253126 no 3215 0.0339726380261101 4612 5718033 SGTC_2108 5365811 200 µM -1.83020540010293 0.0259559322174068 no 3216 0.0336096153075933 4640 780283 SGTC_2087 5276107 200 µM -1.83239011826697 0.0258165485909461 no 3217 0.0334466596204259 4642 144405 SGTC_832 4083-0019 164 µM -1.84035309037974 0.0253138073220762 no 3218 0.0328582078382365 4670 1990758 SGTC_787 4152-0075 138 µM -1.84109357148949 0.0252674768209968 no 3219 0.0328039237877593 4675 9566539 SGTC_1133 3473-0247 50 µM -1.84237677462649 0.025187357475533 no 3220 0.0327100283227726 4604 711311 SGTC_2568 diosmetin 100 µM -1.84934992381131 0.0247556880129854 no 3221 0.0322036506329106 4634 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2855 9016525 58.44 µM -1.85071314764923 0.0246720276023357 no 3222 0.0321054157912549 4591 43811474 SGTC_2400 5203494 178.7 µM -1.85345326596809 0.0245045852836923 no 3223 0.0319087093433779 4554 6777674 SGTC_575 k072-0246 11.9 µM -1.86021685205788 0.0240953568814019 no 3224 0.0314274258742559 4704 6796779 SGTC_118 0083-0097 135.343 µM -1.86102132717809 0.0240470666683824 no 3225 0.0313705824880939 4624 5207356 SGTC_392 N-ethylmaleimide 8.33 µM -1.86891739420143 0.0235773909904986 no 3226 0.0308171539605277 4631 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1117 retinoic acid 1.10837 µM -1.87173309813918 0.0234117837548239 no 3227 0.030621769032088 4686 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2505 galangin 7.89 µM -1.87306065808067 0.0233340427320928 no 3228 0.0305300046229895 4607 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2311 7694451 200 µM -1.87328805939597 0.0233207480813384 no 3229 0.0305143089236335 4643 2163142 SGTC_945 3381-0768 11.3 µM -1.88332839631488 0.0227400784017217 no 3230 0.029827938720901 4643 1126236 YIL048W NEO1 SGTC_1351 1496-0003 46.5 µM -1.88509024159645 0.0226394515574053 no 3231 0.0297088276517472 4669 3891978 SGTC_1092 toremifene 6.32 µM -1.88873408037078 0.0224325262355709 no 3232 0.0294637347952309 4662 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1853 st056710 91.2 µM -1.89158011691915 0.0222720178021522 no 3233 0.0292734735644168 4661 269167 SGTC_2479 5617353 43.85 µM -1.89536482148789 0.0220600730773962 no 3234 0.0290220429351355 4647 2731746 SGTC_2739 tacrine 100.86 µM -1.91157629383334 0.0211713904437133 no 3235 0.0279652811943791 4691 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1231 0242-0792 125 µM -1.93558332399584 0.0199111117321573 no 3236 0.0264593772042171 4649 3707635 SGTC_905 2-aminofluorene 215 µM -1.93618763819601 0.0198802271541512 no 3237 0.0264223619733761 4681 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2028 5153890 36.43 µM -1.93950827052045 0.0197112446803295 no 3238 0.0262197392207878 4655 2830968 YPR165W RHO1 SGTC_2318 6029776 164 µM -1.94107441994689 0.0196319696005457 no 3239 0.0261246256377511 4656 818325 SGTC_288 1315-0019 35.1 µM -1.94290016052326 0.019539896490238 no 3240 0.0260141112727013 4694 6811474 SGTC_1943 st076331 65.2 µM -1.95079354311835 0.0191460379014954 no 3241 0.0255408051280768 4642 24208415 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.95527811962162 0.0189252910167987 no 3242 0.0252751261605945 4651 1377 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.95829419659553 0.0187780496712078 no 3243 0.025097750695877 4632 5282362 SGTC_1844 rapamycin 4 nM -1.95941541785051 0.0187235620653014 no 3244 0.0250320782585705 4504 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3238 9133470 49.47 µM -1.96286077929845 0.0185569702818213 no 3245 0.024831176575156 4690 3534688 SGTC_72 0744-0168 198.391 µM -1.96724927344765 0.0183466046176871 no 3246 0.0245772399919451 4581 677577 SGTC_129 0088-0017 176.636 µM -1.97547506206472 0.0179577653787861 no 3247 0.0241071309568526 4549 182446 SGTC_3057 9095946 49.47 µM -1.98584938445614 0.0174774028653126 no 3248 0.0235250251762846 4707 24540043 SGTC_3272 9137413 49.47 µM -1.98662960411047 0.0174417241169716 no 3249 0.0234817290414894 4638 17614870 SGTC_397 arbidol 50 µM -1.98967253421092 0.0173031673159117 no 3250 0.023313510084184 4691 131410 A RNA synthesis inhibitor. SGTC_2724 maprotiline 69.64 µM -1.99485138275113 0.0170695151732113 no 3251 0.023029545663728 4624 4011 A tricyclic antidepressant. SGTC_763 3453-1109 128 µM -1.99601626891379 0.0170173325547996 no 3252 0.022966075990458 4700 1560353 SGTC_2834 9001755 58.44 µM -1.99680919681299 0.0169818903556532 no 3253 0.0229229570678248 4552 2989575 SGTC_637 1181-0519 7.26 µM -2.00322490830045 0.0166974357255179 no 3254 0.0225765766350664 4694 6252091 YGR060W ERG25 SGTC_1049 3226-0134 66 µM -2.01021603514579 0.0163921198669888 no 3255 0.0222041644982376 4691 5702385 SGTC_119 0121-0043 24.815 µM -2.01211084659832 0.0163101978646681 no 3256 0.0221041267752681 4677 1092378 SGTC_357 1325-0123 420 µM -2.01464513935124 0.0162011762585959 no 3257 0.0219709221213443 4674 1098503 SGTC_1144 3486-0183 12.5 µM -2.01677435326359 0.0161100637347306 no 3258 0.0218595332649548 4699 6744069 SGTC_655 k060-0012 42 µM -2.02490691826626 0.0157660883580243 no 3259 0.0214384615435995 4708 5994525 SGTC_2066 5222451 176 µM -2.03339612276792 0.0154137675308423 no 3260 0.0210062593766655 4633 2281147 SGTC_2569 tetrandrine 100 µM -2.0333964086642 0.0154137557802819 no 3261 0.0210062449462178 4681 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3123 9126162 49.47 µM -2.03342024030658 0.0154127763082432 no 3262 0.0210050420875233 4678 25239884 SGTC_1447 4239-0816 81.9 µM -2.0392045908136 0.0151766166472918 no 3263 0.0207148064640007 4720 1341554 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.04440792902226 0.0149668408950471 no 3264 0.0204566323282468 4681 2374 Ca(2+)-ATPase inhibitor. SGTC_2313 7726885 200 µM -2.04995211076976 0.014746071416161 no 3265 0.020184552132615 4680 726423 SGTC_2371 9071574 200 µM -2.05097365450896 0.0147057005937381 no 3266 0.0201347562241395 4713 45596039 SGTC_627 1391-0720 175 µM -2.06371297592823 0.014210182429297 no 3267 0.0195224691599695 4700 997839 SGTC_1776 st049249 45.9 µM -2.06548374896863 0.0141424568059756 no 3268 0.0194386258105294 4715 1822314 SGTC_386 1509-0011 3.07 µM -2.06678822869184 0.0140927432814404 no 3269 0.0193770565765662 4701 3107280 SGTC_3080 9117754 49.47 µM -2.06878811101553 0.0140168205025937 no 3270 0.0192829872831542 4691 9550191 SGTC_2885 9057732 51.95 µM -2.07239999692964 0.0138805933701822 no 3271 0.0191140768295223 4695 6471414 SGTC_142 0335-0849 62.6745 µM -2.08433475602971 0.0134385458635137 no 3272 0.0185648639930423 4649 3889043 YPR107C YTH1 SGTC_292 k038-0015 474 µM -2.08512797718159 0.0134096016709662 no 3273 0.0185288426659647 4695 46368540 SGTC_822 1487-0950 154 µM -2.09039951918688 0.0132186102694944 no 3274 0.0182909630284375 4694 1958375 SGTC_1816 st051957 91.6 µM -2.0912900584445 0.0131865785936581 no 3275 0.0182510352293845 4708 674121 SGTC_1446 4239-0190 62 µM -2.10823458106135 0.0125897586376325 no 3276 0.0175053517201878 4712 1340085 SGTC_3011 9081274 71.4286 µM -2.10848543903659 0.0125811015082222 no 3277 0.0174945104794017 4711 6625322 SGTC_1252 0493-0875 34.8 µM -2.11917018716056 0.0122171228486722 no 3278 0.0170380434158536 4684 3960963 SGTC_377 3970-0964 33.1 µM -2.14469540706016 0.0113843343893795 no 3279 0.0159886041847361 4719 16481235 SGTC_3353 9151644 39.2805 µM -2.16031900327216 0.0108993101116311 no 3280 0.0153739914234353 4720 4909158 SGTC_3157 9099274 49.47 µM -2.17068910268017 0.0105873961831118 no 3281 0.0149773407475756 4722 17217662 SGTC_2983 9022671 12.99 µM -2.18379375481313 0.0102043750751166 no 3282 0.0144887033569487 4707 6405161 SGTC_2626 ethyl orsellinate 100 µM -2.18641588793794 0.0101292037923224 no 3283 0.0143925961369467 4671 75653 A natural product. SGTC_918 glabranin 770.725 nM -2.19379328484408 0.00992029474186533 no 3284 0.0141251369027064 4704 124049 Also referred to as licorice root. SGTC_2464 5717415 7.67 µM -2.19641240008593 0.00984703818823894 no 3285 0.0140312194569763 4689 5285744 SGTC_2856 9022925 19.48 µM -2.20599608094025 0.00958299503883247 no 3286 0.0136921370561251 4704 4944862 SGTC_2806 7952793 58.44 µM -2.2065846591227 0.00956698255959406 no 3287 0.0136715448493478 4703 2972490 SGTC_1809 st050081 57.6 µM -2.22672639304341 0.00903293232771651 no 3288 0.0129827826907301 4745 5036894 SGTC_2808 7946468 45.46 µM -2.22804163316081 0.00899898556632996 no 3289 0.0129388694226701 4701 2970879 SGTC_652 0437-0092 114 µM -2.23240705461536 0.00888711233948235 no 3290 0.0127940359921655 4712 3091274 SGTC_3033 9090887 49.47 µM -2.23299309655186 0.00887218693675343 no 3291 0.0127746998100646 4731 19325384 SGTC_1201 1889-3372 45.9 µM -2.24159786962728 0.00865555498602544 no 3292 0.0124936868971441 4671 5392199 SGTC_1765 st044815 90.4 µM -2.2436704546772 0.00860407451174124 no 3293 0.012426806218301 4732 645695 SGTC_2173 5763948 167 µM -2.24655077186997 0.00853297702976927 no 3294 0.0123343756514486 4725 2867177 SGTC_2189 6047310 154.431 µM -2.26206043791337 0.00815893049858661 no 3295 0.0118468347328682 4753 711535 SGTC_2830 7992007 71.43 µM -2.27364195250246 0.00788909116377682 no 3296 0.011493761449818 4670 1952075 SGTC_1526 st051518 75 µM -2.27505856835041 0.00785663006134421 no 3297 0.0114512083219501 4715 673993 SGTC_3303 9125618 40.5795 µM -2.292508691228 0.00746630248390041 no 3298 0.010938153303304 4719 22695467 SGTC_2411 st077133 39.94 µM -2.32032056299211 0.00687946576827082 no 3299 0.0101617712725439 4701 1403142 YNL221C POP1 SGTC_2656 pseudo-anisatin 100 µM -2.32610747121741 0.0067626106222294 no 3300 0.0100064090421698 4780 6708809 A neurotoxin. SGTC_1952 st077036 64.1 µM -2.34431050819717 0.00640639073298131 no 3301 0.00953114707569635 4745 2937007 SGTC_2362 9071156 126 µM -2.3450499262534 0.00639227850355934 no 3302 0.00951226595769663 4725 653133 SGTC_2308 7584454 197.62 µM -2.35274531017006 0.00624703265302101 no 3303 0.00931769663015895 4710 893577 SGTC_917 harmaline 728.087 nM -2.35446788723156 0.00621492315242211 no 3304 0.00927462318190953 4684 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3249 9135183 49.47 µM -2.36174442521504 0.00608089282820413 no 3305 0.00909458846883979 4724 4902779 SGTC_1008 4106-0037 6 µM -2.36958974266342 0.00593926132967699 no 3306 0.00890391640527374 4762 2905394 SGTC_1939 st074455 53.6 µM -2.38874972792571 0.00560559043174688 no 3307 0.00845290721429034 4701 1644229 SGTC_2119 5528445 120.635 µM -2.38992945192431 0.00558560054636697 no 3308 0.00842580472193514 4749 791935 SGTC_3280 9140961 49.47 µM -2.39099608482306 0.0055675814650768 no 3309 0.00840136602761508 4751 4901226 SGTC_2418 pentamidine 31.67 µM -2.40220613912742 0.00538130540652665 no 3310 0.00814826107880921 4715 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_657 3534-0529 86.7 µM -2.40481414685907 0.00533877113438951 no 3311 0.00809034620702779 4766 1049549 SGTC_3240 9133527 49.47 µM -2.40954243347838 0.00526241875342969 no 3312 0.00798626926512335 4760 17617455 SGTC_2030 5175110 200 µM -2.42943842350047 0.00495167531002452 no 3313 0.00756111671727896 4769 2831986 SGTC_2031 5180455 200 µM -2.44124259218519 0.00477513853495261 no 3314 0.00731840936017821 4758 29949 SGTC_2674 ligustilide 100 µM -2.47754822198226 0.00426682019755257 no 3315 0.0066144265625464 4791 5319022 A signalling regulator. SGTC_563 tetrahydrosecaminediol 614 µM -2.48840235321989 0.00412454424736824 no 3316 0.00641592346043165 4782 334274 A psychoactive constituent of the cannabis plant. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.50159733112031 0.00395731108987037 no 3317 0.00618172266703657 4734 5379071 SGTC_2504 purpurogallin 52.29 µM -2.50824131515917 0.0038754260213315 no 3318 0.00606668865644822 4730 5281571 An antioxidant. SGTC_969 1313-0238 134 µM -2.57039203410837 0.00317991678712501 no 3319 0.0050791742727076 4772 5212874 SGTC_2607 solasodine 47.35 µM -2.57955520835639 0.00308747828291954 no 3320 0.00494638220275017 4722 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2238 6671620 73.2395 µM -2.58070028947563 0.00307609837633561 no 3321 0.0049300070856038 4716 729941 SGTC_2341 7987486 176.74 µM -2.58204391475127 0.00306279349576623 no 3322 0.00491085431091557 4767 1258686 SGTC_175 3793-3120 23.7 µM -2.60802936529138 0.00281546940893158 no 3323 0.00455325708959363 4760 5322297 SGTC_1834 st055981 52.8 µM -2.62205587546731 0.00268959185113793 no 3324 0.00437005501505964 4748 471719 YDL150W RPC53 SGTC_1944 st076371 56.9 µM -2.6305788616036 0.00261560896264246 no 3325 0.00426197953195429 4761 24208455 SGTC_744 1594-0068 283 µM -2.63083837536324 0.00261338540626012 no 3326 0.00425872659817456 4775 668392 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.66183687531696 0.0023597516532536 no 3327 0.00388577655663699 4762 3256 An antibiotic and ribosome inhibitor. SGTC_489 paxilline 115 µM -2.67608244347065 0.00225084495507787 no 3328 0.00372441596801096 4763 105008 A toxic potassium channel blocker. SGTC_3067 9117431 49.47 µM -2.68743174333679 0.00216736175879159 no 3329 0.00360019083866864 4769 17150885 SGTC_184 1494-0393 24.714 µM -2.69402614579541 0.00212015398197576 no 3330 0.00352973133685159 4754 3090647 SGTC_2846 9008642 19.48 µM -2.72834197101177 0.00188921508063491 no 3331 0.00318267905940796 4771 2992898 SGTC_2477 5967686 25.23 µM -2.74058632576132 0.00181251331027649 no 3332 0.00306648344379074 4768 776118 SGTC_3343 9148379 18.9835 µM -2.77974520191371 0.00158583901066769 no 3333 0.00272007825893072 4795 1955036 SGTC_824 1304-0008 100 µM -2.80326866068159 0.00146241375589824 no 3334 0.00252937548818056 4783 768245 SGTC_745 0469-0705 296 µM -2.82956483777572 0.00133486312783975 no 3335 0.00233056771785174 4796 3486736 SGTC_475 α-linolenic acid 10 µM -2.85012883825025 0.00124229318992915 no 3336 0.00218507614222935 4786 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2044 5102272 200 µM -2.85180957738937 0.00123499313328306 no 3337 0.0021735566735431 4789 592666 SGTC_456 gingerol 170 µM -2.86439881846752 0.00118154933173102 no 3338 0.00208900804549304 4775 442793 A herb. SGTC_2379 9035213 200 µM -2.88549479425097 0.00109671916346536 no 3339 0.00195399462376983 4777 646551 SGTC_114 0364-0001 490.298 µM -2.91364222128649 0.000992221304757956 yes 3340 0.00178619535446821 4782 4003655 SGTC_2315 7733312 200 µM -2.93391171678284 0.000922719110281675 yes 3341 0.0016735969946194 4759 726316 SGTC_1729 st035615 45.989 µM -2.98651949310818 0.000762674547170013 yes 3342 0.00141086424101274 4775 17385451 SGTC_2603 homopterocarpin 100 µM -3.02929050726296 0.000651850037047826 yes 3343 0.00122564422276307 4770 101795 A weak amylase inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM -3.13572831554419 0.000437340406252581 yes 3344 0.00085713966324618 4789 5282309 SGTC_2423 st077119 87.2 µM -3.15281250012139 0.000409747015423896 yes 3345 0.000808528180672588 4742 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2340 7987427 183.45 µM -3.18114596019888 0.000367519142859874 yes 3346 0.000733468504948723 4786 2239331 SGTC_1227 3909-8010 46.6 µM -3.18968621209315 0.000355606694045748 yes 3347 0.000712136741042762 4800 15982272 SGTC_3097 9117246 49.47 µM -3.26592590035282 0.000264081737228427 yes 3348 0.000545533979368185 4805 16423892 SGTC_2444 5485484 36.41 µM -3.41781558962506 0.00014331777939954 yes 3349 0.000315629311649541 4799 6790631 SGTC_1954 st077032 68.9 µM -3.50319568488832 0.000100558141566966 yes 3350 0.000229855803182469 4791 698907 SGTC_2038 4100038 30.985 µM -3.53082236027603 8.95164678128584e-05 yes 3351 0.000207134934226507 4788 3596803 SGTC_1764 st044502 93.5 µM -3.67918375211887 4.72693479744857e-05 yes 3352 0.000116990820214724 4803 8407 SGTC_2434 5670830 169.91 µM -3.71365837773008 4.06139610063773e-05 yes 3353 0.000102142259245723 4804 1549830 SGTC_351 caspofungin 25 nM -3.72694879551169 3.82931295977648e-05 yes 3354 9.69059067491369e-05 4806 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1733 st037357 54.9 µM -3.78912416424804 2.90054985615352e-05 yes 3355 7.55896713882274e-05 4792 1272339 YGL099W LSG1 SGTC_2597 laccaic acid a 100 µM -4.16916877910762 4.85142597054144e-06 yes 3356 1.52856271469052e-05 4801 5491415 A textile dye.