SGTCid condition conc unit HMI1|YOL095C.score HMI1|YOL095C.strain.pval HMI1|YOL095C.strain.significant HMI1|YOL095C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_236 1509-0011 5.31 µM 15.0787613538272 7.09611618414204e-42 yes 1 1.11710577494333e-51 101 3107280
SGTC_173 1273-0061 2.693 µM 11.2278407472127 4.00987994870915e-24 yes 2 1.4883197403986e-29 32 2847414 YPL266W DIM1
SGTC_310 1273-0058 1.06 µM 8.1383927684212 1.43268208365513e-13 yes 3 2.00279794205992e-16 84 2734232
SGTC_275 trichlorophene 5.69 µM 8.08729970787464 2.01000268252712e-13 yes 4 3.05010150091828e-16 73 62616
SGTC_10 0279-0212 42.575 µM 7.28113741793865 3.20267849083609e-11 yes 5 1.655086405105e-13 11 39851 YBR002C RER2
SGTC_908 3448-7491 47.7 µM 6.85344910154305 3.83792345884947e-10 yes 6 3.60451547189778e-12 30 1203031
SGTC_161 4065-0411 162.148 µM 6.36951355378705 5.36645751570133e-09 yes 7 9.48143314812662e-11 23 1906281 YLR208W SEC13
SGTC_876 0720-0963 56.8 µM 6.28879387062279 8.1856777427797e-09 yes 8 1.59970975588985e-10 2 765861
SGTC_63 0099-0242 26.702 µM 6.20207049678828 1.28116594126488e-08 yes 9 2.78625519443337e-10 25 3898502 YLR359W ADE13
SGTC_2454 5-benzylidenerhodanine 10.36 µM 5.71228043494738 1.44121536491851e-07 yes 10 5.57360959127559e-09 14 1273210
SGTC_988 1497-1057 103 µM 5.48430987130535 4.17275910984071e-07 yes 11 2.07543318142925e-08 1 3533044
SGTC_1319 1306-0155 43.7 µM 5.45625431348227 4.74281377022955e-07 yes 12 2.43141663940048e-08 4 3122360
SGTC_820 1582-0060 59.9 µM 5.45561470668583 4.75664614123426e-07 yes 13 2.44018570573955e-08 9 3848840
SGTC_119 0121-0043 24.815 µM 5.24727880316499 1.20772794521737e-06 yes 14 7.71811052127103e-08 47 1092378
SGTC_1627 st003713 25.6 µM 5.18812239795115 1.56395074782167e-06 yes 15 1.06212486021917e-07 39 16195070 YER133W GLC7
SGTC_832 4083-0019 164 µM 5.11836657019795 2.11390760720458e-06 yes 16 1.54096577497609e-07 34 1990758
SGTC_1318 1280-3875 124 µM 5.02307365664492 3.17123349865008e-06 yes 17 2.5425515651455e-07 9 373245
SGTC_1742 st038235 28.8875 µM 4.9750973248705 3.87937092752084e-06 yes 18 3.26074329792778e-07 76 564103 YBR002C RER2
SGTC_1373 2887-0003 58.5 µM 4.81980174411068 7.35926644750353e-06 yes 19 7.18504768203743e-07 8 776948
SGTC_1597 7-benzyloxygramine 47.5 µM 4.69798952279912 1.20041449963805e-05 yes 20 1.31367452988844e-06 77 260807
SGTC_28 pentachloropyridine N-oxide 1.606 µM 4.68776988339528 1.250070798296e-05 yes 21 1.38099166795298e-06 37 140250 A respiratory chain inhibitor.
SGTC_68 0986-0284 82.829 µM 4.67606524782503 1.30934247400832e-05 yes 22 1.46215798613807e-06 43 423278 YIL048W NEO1
SGTC_748 act1.228 77.9 µM 4.66046650629404 1.39249796150893e-05 yes 23 1.57746749652613e-06 56 4421505 YNR035C ARC35
SGTC_767 0929-0023 86 µM 4.62199112738054 1.61960201136824e-05 yes 24 1.90037136873974e-06 47 1204563
SGTC_2250 alverine citrate 130 µM 4.53693268703193 2.25277679208837e-05 yes 25 2.85391573791168e-06 123 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3018 9082602 49.47 µM 4.53035885264091 2.31043688949614e-05 yes 26 2.94417918047892e-06 43 17332089
SGTC_147 4466-0538 29.23 µM 4.36360285977374 4.33839860502583e-05 yes 27 6.39688717896734e-06 9 6742687 YHR072W ERG7
SGTC_19 0279-0214 38.434 µM 4.18985514193397 8.17820631477685e-05 yes 28 1.39566296125062e-05 36 3566274 YBR002C RER2
SGTC_831 k061-1017 217 µM 4.11993301071036 0.000104869786620305 yes 29 1.89491284237975e-05 56 1240153
SGTC_1615 st002656 86.5 µM 4.09551154631736 0.000114284995858385 yes 30 2.10618615641602e-05 13 1584458
SGTC_721 1187-1332 279 µM 4.079556911537 0.000120858402758428 yes 31 2.25608112795391e-05 15 25730
SGTC_1165 k072-0275 30.3 µM 3.93369909981888 0.000199727442307521 yes 32 4.18242444342109e-05 44 6153523 YGL055W OLE1
SGTC_2232 chlorophetanol 41.5365 µM 3.91351562168927 0.0002138338608963 yes 33 4.54810064364253e-05 127 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1183 1254-0324 198 µM 3.88673506873767 0.000233989682579034 yes 34 5.08007680770536e-05 23 5799357
SGTC_830 4076-0286 57.8 µM 3.86442465722394 0.000252120246899948 yes 35 5.56756764636318e-05 65 6866659
SGTC_2045 5106652 78.05 µM 3.79846390964321 0.000313673770387748 yes 36 7.27978120092451e-05 16 673349
SGTC_3152 9099253 49.47 µM 3.77863407663564 0.00033475036457921 yes 37 7.88454712635865e-05 141 25236131
SGTC_144 4161-2749 112.381 µM 3.75789554117116 0.00035819597868518 yes 38 8.56741897446182e-05 28 797501 YMR168C CEP3
SGTC_734 2023-0417 80 µM 3.73808623636594 0.000382007504898046 yes 39 9.27131747076094e-05 23 3935732
SGTC_3323 9138564 53.9225 µM 3.68692941266408 0.000450466516953543 yes 40 0.000113488141518283 29 43912313 YNL103W MET4
SGTC_2472 5377652 49.4 µM 3.67931278227178 0.000461581610825109 yes 41 0.000116931649367849 72 1610903
SGTC_1805 st050013 60.3 µM 3.67431059339492 0.000469019079308084 yes 42 0.000119246241057055 10 4037144
SGTC_1434 4073-0095 163 µM 3.6284967317768 0.000542489739726959 yes 43 0.000142538179195342 17 24133745
SGTC_782 0083-0095 30.5 µM 3.6264878091286 0.000545942909983859 yes 44 0.000143651188338015 41 3591729 An indicator and reagent.
SGTC_609 0986-0026 86.3 µM 3.5399278364009 0.000715545813800752 yes 45 0.000200118227852187 45 2848610
SGTC_1623 st003709 20.3 µM 3.48984921105136 0.000834639782167337 yes 46 0.000241646580752334 94 16192618
SGTC_1624 st003710 6.25 µM 3.47825042601391 0.000864706970680601 yes 47 0.000252349087263134 60 24207033
SGTC_1912 st060209 90.8 µM 3.4779323354322 0.00086554540728696 yes 48 0.000252648730679803 52 688787
SGTC_1626 st003712 1.76 µM 3.46102975416621 0.000911188257788426 yes 49 0.000269056666622465 41 24207035
SGTC_967 1306-0166 352 µM 3.45326858058134 0.000932878302116299 yes 50 0.000276918639742624 55 4437607
SGTC_625 k213-0058 121 µM 3.43560945123924 0.000984008647862369 yes 51 0.000295611295921325 158 3655420
SGTC_211 3455-0679 143.504 µM 3.42494450281679 0.00101612122564528 no 52 0.00030746250882774 35 748649
SGTC_2439 5492030 7.2 µM 3.39960521893188 0.00109631205372061 no 53 0.000337416049084532 27 5722370
SGTC_2852 9023854 51.95 µM 3.34365811823157 0.00129430066957537 no 54 0.000413407807994013 44 19798528
SGTC_1025 k007-0731 70 µM 3.32564499670235 0.00136469032081351 no 55 0.000441071022070766 38 6256118
SGTC_3003 9075612 71.4286 µM 3.3159826554824 0.00140387264532849 no 56 0.000456607481782104 41 6501993
SGTC_1300 1094-0077 113 µM 3.29396857277416 0.00149700827921775 no 57 0.000493917712338245 28 5532636
SGTC_1824 st053723 68.6 µM 3.26824630748763 0.00161295324761343 no 58 0.000541080722227052 58 675225
SGTC_802 4112-3352 742 µM 3.25748788740415 0.00166382993010692 no 59 0.000562015276946283 48 704594
SGTC_944 3370-0224 231 µM 3.2555051387887 0.00167336434310269 no 60 0.000565954240458951 53 4580514
SGTC_204 PMA1.184 62.41 µM 3.24387994019693 0.00173027431426837 no 61 0.000589567179219645 57 2252213 YGL008C PMA1
SGTC_1883 5-benzylidenerhodanine 20 µM 3.20741969049544 0.00192037488668998 no 62 0.000669657245997015 114 1273210
SGTC_118 0083-0097 135.343 µM 3.20195924208789 0.00195042472763343 no 63 0.000682481547001885 235 5207356
SGTC_1921 5740136 50 µM 3.18398271084454 0.00205239485660377 no 64 0.000726318441790077 94 1774243
SGTC_2176 5809774 33.9695 µM 3.1829710204381 0.00205827485553008 no 65 0.000728861016568473 37 2870539
SGTC_2347 9049783 174.81 µM 3.1647055476466 0.00216709788874157 no 66 0.000776199837024065 64 6467988 YPL169C MEX67
SGTC_2585 alliin 100 µM 3.156116753507 0.00222004994162796 no 67 0.000799424235819111 64 87310 A garlic compound which reacts with lipids.
SGTC_157 1348-1695 65.819 µM 3.14925004033367 0.00226322538121194 no 68 0.000818450370962626 123 5380510
SGTC_646 4092-0839 27.3 µM 3.14906098623216 0.00226442477265015 no 69 0.000818980043923476 53 877796
SGTC_1882 5615643 20 µM 3.14068618869927 0.00231813711842737 no 70 0.000842762655030616 48 2253075
SGTC_2316 5844804 197.44 µM 3.13830270614006 0.00233363323676588 no 71 0.000849646441281996 80 776813
SGTC_2380 9035439 200 µM 3.13767626436658 0.00233772155752646 no 72 0.000851464243933486 70 6462575
SGTC_2041 5107442 45.335 µM 3.12342425445247 0.00243250323842451 no 73 0.000893799351336518 65 793005
SGTC_2183 6420625 130.508 µM 3.12071083614426 0.0024509377041173 no 74 0.000902075483745611 104 2897619
SGTC_1622 st003707 19.4 µM 3.09194876144313 0.00265425562676925 no 75 0.000994235844072647 84 10140899
SGTC_177 1327-0068 8.361 µM 3.04259282984189 0.00303890547194436 no 76 0.00117274730507167 89 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1371 2421-0008 32.7 µM 3.0322374952823 0.0031257173887545 no 77 0.00121374065543706 87 2827552
SGTC_2204 7233102 200 µM 3.02899855792372 0.00315332513627358 no 78 0.001226829271009 27 2172480
SGTC_527 4476-4215 268 µM 3.02584837347192 0.0031803867196556 no 79 0.00123968300958677 86 4418754
SGTC_2940 9060638 45.86 µM 3.0117599809206 0.00330398771544824 no 80 0.00129868939975731 77 4027022
SGTC_2595 hexamethylquercetagetin 100 µM 3.00852399410394 0.0033329808429894 no 81 0.00131260035665499 69 386331
SGTC_192 3455-0609 60.9 µM 3.00188057771051 0.00339322104014046 no 82 0.00134158706736135 54 3769639
SGTC_148 3253-0744 288.01 µM 2.99159902951483 0.0034883808868949 no 83 0.00138760255474449 68 6893655
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.96941205463855 0.00370194183505439 no 84 0.0014918510251847 51 66535 A nucleotide analog.
SGTC_3056 9094900 49.47 µM 2.96744302009086 0.0037214500175125 no 85 0.00150143967732646 69 25236784
SGTC_2688 kanamycin b 96.69 µM 2.96472683285378 0.00374851191972968 no 86 0.00151475903435933 543 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1509 1326-1131 80 µM 2.90387935473427 0.00440285699657216 no 87 0.00184285078115408 45 768313
SGTC_3354 9151612 71.43 µM 2.89957663454324 0.00445277850069806 no 88 0.00186833494458546 58 27261949
SGTC_442 cape 100 µM 2.89414472894559 0.0045165228552236 no 89 0.00190096438430313 45 5281787
SGTC_3101 9120531 49.47 µM 2.87129556532886 0.00479367460582358 no 90 0.00204396551628776 97 24824904
SGTC_2245 6637752 200 µM 2.86796318652306 0.00483533765603924 no 91 0.00206561799895561 46 681890
SGTC_2769 toremifene 3.73 µM 2.86711771069536 0.00484595941914351 no 92 0.00207114456773075 71 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3183 9108214 49.47 µM 2.86175927133984 0.00491376274671391 no 93 0.00210648381612658 12 4974831
SGTC_1807 st050092 58.9 µM 2.86058652026374 0.00492871449465333 no 94 0.00211429076582178 58 5008496
SGTC_2094 5332512 191.667 µM 2.83566406912448 0.0052561894427766 no 95 0.00228652596702019 84 755774
SGTC_601 0986-0029 62.9 µM 2.82134188866438 0.0054530136482573 no 96 0.00239116026998193 106 24747981
SGTC_3113 9123498 49.47 µM 2.80401552029503 0.00569985921826003 no 97 0.00252352377555964 56 8897275
SGTC_1812 st052057 4.327 µM 2.80358053188365 0.00570618205065109 no 98 0.00252693045901931 89 3645418
SGTC_1166 k206-0078 225 µM 2.7973968755455 0.00579674115471772 no 99 0.00257581048737591 79 5404595
SGTC_672 1441-0018 53.7 µM 2.74381031702812 0.0066364589742521 no 100 0.0030365309115999 68 251141
SGTC_751 0833-0568 350 µM 2.74315862911442 0.00664730088390199 no 101 0.0030425640892334 85 6954252
SGTC_1822 st052468 42 µM 2.74113071739891 0.00668113879451532 no 102 0.00306140716871703 56 2873678
SGTC_2682 pyrogallin 40.03 µM 2.72279628705173 0.00699404507893174 no 103 0.00323659797772892 103 822798 An ATP competetive kinase inhibitor.
SGTC_1441 4106-0040 13 µM 2.71946625803324 0.00705224522161876 no 104 0.00326936829098767 61 2904180
SGTC_1641 st009299 47.1 µM 2.71801302417252 0.00707777759766595 no 105 0.0032837626444937 40 4046054
SGTC_3090 9117696 49.47 µM 2.71575235576643 0.00711765822499573 no 106 0.00330626798987721 64 7923821
SGTC_3002 9075603 71.4286 µM 2.71058958460856 0.00720947926981809 no 107 0.00335818512723619 94 20105405
SGTC_2194 5927483 104.545 µM 2.7095581594837 0.00722794809436631 no 108 0.00336864460252017 87 760979
SGTC_1111 tnp00062 510.699 nM 2.70036106909281 0.0073944856661521 no 109 0.00346321295913862 67 676306
SGTC_1804 st050076 49.1 µM 2.68752562325514 0.00763255511647082 no 110 0.00359917896155555 93 3895976
SGTC_744 1594-0068 283 µM 2.64900392946438 0.00838804193034515 no 111 0.00403646964937398 119 668392
SGTC_3206 9114350 49.47 µM 2.6363781523909 0.00864955812343854 no 112 0.00418981445923385 82 17087243
SGTC_1485 3909-9022 254 µM 2.62019444024515 0.0089952087394269 no 113 0.00439398223837845 78 714516
SGTC_1090 efavirenz 20.7 µM 2.60111458424786 0.00941820533284621 no 114 0.00464607057844996 100 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_116 0155-0182 31.788 µM 2.59060545195544 0.00965854108158375 no 115 0.00479036317478903 220 771486
SGTC_2743 auranofin 4.32 µM 2.58861272775061 0.00970471276337744 no 116 0.00481817003388938 115 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2107 5363541 170.161 µM 2.58777623725388 0.00972415175369356 no 117 0.00482988540152306 79 244052
SGTC_2032 5185112 25.99 µM 2.58743097626123 0.00973218509936159 no 118 0.00483472831217193 79 5718189
SGTC_386 1509-0011 3.07 µM 2.58202575492755 0.00985870888120494 no 119 0.00491111272840872 250 3107280
SGTC_1998 st075797 76.8 µM 2.57207064825178 0.0100954975704228 no 120 0.00505461300698264 102 24208315
SGTC_1073 triclabendazole 3.09 µM 2.56341785278005 0.0103053259154086 no 121 0.00518236123665966 142 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_797 k781-0471 270 µM 2.56162632375002 0.0103492421834099 no 122 0.00520916727640401 99 23738129
SGTC_1860 st056228 74.6 µM 2.55129399879412 0.0106057190403707 no 123 0.00536618746966303 99 688679
SGTC_2954 9074818 52.69 µM 2.55096051398374 0.0106140884829379 no 124 0.00537132480059885 119 16648742
SGTC_2737 bleomycin 30.5 nM 2.53385545573615 0.0110511597574823 no 125 0.00564076282431298 193 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.5330747318825 0.0110714771787204 no 126 0.00565334222261582 88 756377
SGTC_3298 9116858 71.43 µM 2.52843335708546 0.0111929354521342 no 127 0.0057286417753507 89 2506942
SGTC_2279 7948423 32.93 µM 2.52710720943822 0.0112278509678797 no 128 0.00575031947511824 80 1247112
SGTC_441 propafenone 146 µM 2.50453879658208 0.0118367248964198 no 129 0.00613055787236876 56 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2555 cholic acid 100 µM 2.50393124490993 0.0118535045460959 no 130 0.00614109497125175 84 6708657 Influences liver metabolism.
SGTC_2333 9017922 200 µM 2.49835708362206 0.0120084200366012 no 131 0.00623852206571215 129 3163164
SGTC_2995 9067767 71.4286 µM 2.49637614757599 0.0120638949204213 no 132 0.0062734737646913 111 11673567
SGTC_503 tyrphostin 8 294 µM 2.49533482831694 0.0120931454197354 no 133 0.00629191627054672 142 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1629 st005085 44.9 µM 2.49495040201883 0.012103959424368 no 134 0.00629873685559321 145 24207091
SGTC_1891 st059073 26.2 µM 2.49376479765377 0.01213736357376 no 135 0.00631981337909839 115 688754
SGTC_735 3076-0345 636 µM 2.49344505341304 0.01214638596936 no 136 0.00632550816017723 155 2888990
SGTC_673 1082-0474 110 µM 2.49225551291194 0.0121800029383839 no 137 0.00634673428837755 200 3098046
SGTC_619 1652-1634 108 µM 2.49091400649583 0.0122180112558566 no 138 0.00637074771226345 110 5400454
SGTC_400 oxethazaine 37.5 µM 2.48714589149011 0.0123253219357859 no 139 0.00643862894860286 102 4621 A local anesthetic.
SGTC_3165 9101544 49.47 µM 2.48421862558344 0.0124092490207577 no 140 0.0064918034667423 98 5002184
SGTC_66 0109-0187 42.4 µM 2.47442307002642 0.0126937049122907 no 141 0.00667257792344021 132 759417
SGTC_413 propylparaben 100 µM 2.46986739529927 0.0128279094860295 no 142 0.00675815725403114 117 7175 A pharmaceutical preservative.
SGTC_2052 5265182 7.135 µM 2.46667293533198 0.0129227448039864 no 143 0.00681874290944581 130 1239884
SGTC_1297 1068-0111 14.1 µM 2.45119094854898 0.0133910023123848 no 144 0.00711921990610398 104 767057
SGTC_70 0141-0289 43.283 µM 2.44293802421532 0.0136465495026357 no 145 0.00728411940713817 384 352408
SGTC_3122 9126309 49.47 µM 2.43650615808283 0.0138486159720758 no 146 0.00741495847257522 86 17591206
SGTC_33 0986-0033 35.816 µM 2.43325838247052 0.0139516263734154 no 147 0.00748180928202385 101 2848082
SGTC_264 promethazine 12.5 mM 2.42350535039528 0.0142649451465211 no 148 0.00768576341468371 207 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_892 0929-0076 29 µM 2.42163517780195 0.0143257124863412 no 149 0.00772542665553331 179 5751038
SGTC_2144 5628481 200 µM 2.41992632130175 0.014381432981941 no 150 0.00776182604683168 116 2818399
SGTC_1178 0988-0033 191 µM 2.40888004370236 0.0147461389961584 no 151 0.00800077822421133 175 5392207
SGTC_3137 9097352 49.47 µM 2.40018858226321 0.0150386638127992 no 152 0.00819331366897762 182 44120435
SGTC_1154 4088-0362 150 µM 2.38845144083753 0.0154416011504743 no 153 0.0084597720459288 169 6618304
SGTC_614 0462-0418 107 µM 2.36343806308986 0.0163313274045936 no 154 0.00905312646639832 165 5188303
SGTC_2411 st077133 39.94 µM 2.36061092095584 0.0164345976519965 no 155 0.00912243061543759 173 1403142 YNL221C POP1
SGTC_2978 9011784 42.97 µM 2.35771042901388 0.0165411277681982 no 156 0.0091940151575778 192 2994934
SGTC_596 1155-0152 116 µM 2.35740005234729 0.0165525623028556 no 157 0.00920170434216225 185 280313
SGTC_1224 0823-0416 294 µM 2.35481627371954 0.0166480137067013 no 158 0.00926593290949045 125 3598164
SGTC_593 1203-0218 61.7 µM 2.34186523585337 0.0171335858440901 no 159 0.00959382090601315 124 3666956
SGTC_120 rhodamine 6G 52.259 µM 2.33087720990218 0.017555000183262 no 160 0.00987991766164237 183 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.32998807884764 0.0175894839270976 no 161 0.00990339059769944 156 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1289 0976-0073 69.1 µM 2.32673289317867 0.0177162256349264 no 162 0.00998974300966064 121 3391136
SGTC_1613 st002381 52.1 µM 2.32260141008245 0.0178782076912545 no 163 0.0101002874528377 135 551167
SGTC_2078 5212016 200 µM 2.31842510221653 0.0180432292963072 no 164 0.0102131145594331 109 1899708
SGTC_2828 7998861 71.43 µM 2.30001028600577 0.0187864403301434 no 165 0.0107238186530486 110 2988188
SGTC_818 4072-2707 53.5 µM 2.29813756511689 0.0188634611991747 no 166 0.0107769804113313 125 882871
SGTC_2646 retinol 96.75 µM 2.29570662225808 0.0189638410602892 no 167 0.010846330778156 121 445354 A vitamin A analog and teratogen.
SGTC_886 0866-0150 153 µM 2.29215003845833 0.0191115199002312 no 168 0.01094849340016 168 271463
SGTC_2426 5582046 32.21 µM 2.28933982583439 0.0192288978934366 no 169 0.0110298077185274 170 2251934
SGTC_218 alverine citrate 93.75 µM 2.28241641682884 0.0195206944461174 no 170 0.0112323835050417 126 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1131 3454-3128 32.3 µM 2.27509755339236 0.0198332386821472 no 171 0.0114500392041957 205 710982
SGTC_2973 9094665 17.96 µM 2.26625837359416 0.020216358637323 no 172 0.011717784237044 191 25237061 YIL048W NEO1
SGTC_1483 3453-0561 55.9 µM 2.26196274327166 0.020404800120574 no 173 0.0118498526290607 164 4546991
SGTC_3048 9093155 49.47 µM 2.25975330908349 0.0205023023365224 no 174 0.011918282848661 98 25236002
SGTC_206 4546-0025 72.014 µM 2.25705060156054 0.0206221092035833 no 175 0.0120024565346704 227 6620745 YIL048W NEO1
SGTC_1825 st052143 62.6 µM 2.2522524439761 0.0208362651711068 no 176 0.0121531617821866 122 674173
SGTC_2345 9052315 157.45 µM 2.2454408157873 0.0211435198655483 no 177 0.0123699238275521 168 6469265
SGTC_2148 5546263 113.568 µM 2.22990217506667 0.0218587970277069 no 178 0.0128769689858825 155 792097
SGTC_2375 9072683 200 µM 2.22575913107313 0.0220529252299589 no 179 0.013015159829243 187 16798029
SGTC_2254 7938975 95.19 µM 2.22436034645099 0.0221187950262767 no 180 0.013062104767096 210 2969277
SGTC_3033 9090887 49.47 µM 2.20742238711818 0.0229296820000976 no 181 0.0136422818831428 190 19325384
SGTC_3187 9109394 49.47 µM 2.20023773291611 0.0232811276348459 no 182 0.0138950162401955 188 17098090
SGTC_1335 1486-0900 202 µM 2.19625134700914 0.023478074501024 no 183 0.0140369790026858 195 X1335
SGTC_700 3453-2283 142 µM 2.19004362593271 0.0237875560218555 no 184 0.0142605365283851 204 565664
SGTC_681 1642-0006 26.6 µM 2.18602907991662 0.0239895189436175 no 185 0.0144067389363255 102 4446530
SGTC_195 4234-0266 16.654 µM 2.18333482737982 0.024125867270641 no 186 0.0145055807847039 217 2303354
SGTC_1762 st045503 25.4615 µM 2.18302090483969 0.0241417962448305 no 187 0.0145171352844871 185 4645554
SGTC_778 3456-2434 196 µM 2.17275842216864 0.0246674182884259 no 188 0.0148992520630111 260 5539063
SGTC_2497 7-hydroxyflavone 100 µM 2.1714525649606 0.0247349850013721 no 189 0.0149484895646659 170 5281894
SGTC_2972 9093619 59.92 µM 2.17074528873892 0.024771645143496 no 190 0.0149752158500954 184 25236256
SGTC_1488 4013-0813 75.9 µM 2.16155427853329 0.025252200021354 no 191 0.0153262744474696 123 2910057
SGTC_1596 piperlongumine 63 µM 2.16121024104806 0.0252703387483421 no 192 0.0153395513446219 168 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.15478601954697 0.0256110538602877 no 193 0.0155892913817614 107 88881 An O-methylated flavonoid and antioxidant.
SGTC_2669 eugenol 100 µM 2.15324102377928 0.0256935655297476 no 194 0.0156498705546938 104 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1843 st055809 45.5 µM 2.14628069399815 0.0260680514742343 no 195 0.015925295465775 174 16413835
SGTC_2963 9082507 9 µM 2.14594899315138 0.0260860113105255 no 196 0.0159385241897112 167 16459611
SGTC_946 3434-1334 87.4 µM 2.14514705955344 0.0261294745053386 no 197 0.0159705454224389 177 4047976
SGTC_907 3448-6986 75.5 µM 2.13443901581627 0.0267156548918385 no 198 0.0164034303477876 211 590582
SGTC_968 1309-0633 340 µM 2.13043877614219 0.0269374357124691 no 199 0.0165677026723346 166 3761976
SGTC_3226 9131256 49.47 µM 2.12219200830599 0.0273995042046827 no 200 0.0169108086926021 53 17178073
SGTC_720 r052-1644 49.9 µM 2.10830313680546 0.0281926335086699 no 201 0.0175023884013369 160 1422863 YOR257W CDC31
SGTC_2598 perillyl alcohol 100 µM 2.10648512861344 0.0282978523487858 no 202 0.0175811167817979 228 10819 An apoptosis inducer.
SGTC_3327 9140648 26.9345 µM 2.09902218599524 0.0287332071515125 no 203 0.0179074725186074 161 8029710
SGTC_2533 agelasine 13.65 µM 2.09835019088429 0.0287726802030717 no 204 0.0179371109162166 238 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2750 bromebric acid 70.15 µM 2.09228225531929 0.0291311569323539 no 205 0.0182066370487332 231 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1240 0356-0016 42.1 µM 2.09221385374698 0.0291352189599845 no 206 0.018209694881191 209 4305613
SGTC_1354 1498-1681 81 µM 2.08823999258527 0.029372015759621 no 207 0.0183880957114839 205 5754243
SGTC_1900 st060200 72.8 µM 2.07752832622511 0.0300182792959023 no 208 0.0188764118186571 179 688945
SGTC_1620 st003704 16.5 µM 2.07346115673921 0.0302667312349836 no 209 0.0190646912345351 159 2834414
SGTC_2506 ethyl hematommate 54.16 µM 2.07053144551864 0.0304467530511005 no 210 0.0192013022311518 169 3940691 An allergen.
SGTC_633 0437-0093 97.7 µM 2.06973684200343 0.0304957316510943 no 211 0.0192384973349355 164 2831118
SGTC_761 k216-0224 480 µM 2.06627246783583 0.0307100355681671 no 212 0.0194013797823113 207 1340404
SGTC_502 l-744,832 89.3 µM 2.06455214226535 0.0308169162512317 no 213 0.0194826977268038 204 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2097 5376186 200 µM 2.06227677661223 0.0309587533647002 no 214 0.0195906963629694 222 742755
SGTC_365 0121-0052 13.6 µM 2.0441705617807 0.0321067819243975 no 215 0.020468350147533 312 3101739
SGTC_546 peri-Naphthalide 147 µM 2.03840200386779 0.0324798385674166 no 216 0.020754873033237 204 223824 A penicillin ester.
SGTC_1922 5578187 25 µM 2.03609346487063 0.0326301318789378 no 217 0.0208704854238148 237 1350412
SGTC_1987 st072290 61.9 µM 2.0328661518727 0.0328412012459968 no 218 0.0210330237722973 193 54697379
SGTC_2112 5488546 200 µM 2.03085943816515 0.0329730088120129 no 219 0.0211346277286109 222 600757
SGTC_1935 st074532 41.6 µM 2.03054827490978 0.0329934860280755 no 220 0.0211504196754164 258 2829742
SGTC_2508 celastrol 40.54 µM 2.02963218467976 0.0330538334890111 no 221 0.0211969704325991 165 122724 Celastrol is a natural product and antioxidant.
SGTC_141 0443-0274 32.331 µM 2.02516368247439 0.0333495013305341 no 222 0.0214252797622278 335 1627241
SGTC_1487 3970-0795 2.82 µM 2.02514587946337 0.0333506836456772 no 223 0.0214261935135004 205 3765103
SGTC_1361 1608-0041 5.61 µM 2.0170155623916 0.0338942443217109 no 224 0.0218469446460145 201 X1361
SGTC_2994 9053520 71.4286 µM 2.01471169158532 0.034049590262185 no 225 0.0219674332299879 207 4647384
SGTC_2821 7996764 71.43 µM 2.01370069419341 0.0341179446209995 no 226 0.0220204835524004 275 2987135
SGTC_2885 9057732 51.95 µM 2.01223949967378 0.0342169365040452 no 227 0.0220973482711278 215 6471414
SGTC_961 1252-1571 372 µM 2.01010038103859 0.034362281580974 no 228 0.0222102828782634 229 6813498
SGTC_1185 1319-0113 81.3 µM 2.00860612365269 0.0344641114456622 no 229 0.022289460692286 183 4672763
SGTC_2360 9040895 200 µM 2.00554184419653 0.0346737099411574 no 230 0.0224525760058979 201 4914414
SGTC_1769 st044406 64.4 µM 2.0046170297359 0.0347371730500705 no 231 0.0225020023189102 229 670903
SGTC_2156 5649887 115 µM 2.0017216647495 0.0349364773373736 no 232 0.0226573375028344 234 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.98679911981757 0.0359786172723099 no 233 0.0234723311055702 278 2724 A muscle relaxant with antifungal properties.
SGTC_1062 mesoridazine 14.2 µM 1.98564148991386 0.0360605154019864 no 234 0.0235365730340431 246 4078 A neuroleptic.
SGTC_269 exalamide 29 µM 1.98261094848528 0.0362756384659446 no 235 0.0237054517390859 179 3316 A derivative of salicylamide.
SGTC_2553 4-methylesculetin 85.09 µM 1.97200865947723 0.0370365232050403 no 236 0.0243043089948807 241 5319502
SGTC_2526 patulin 37.61 µM 1.97162157353921 0.0370645478166532 no 237 0.0243264112752745 338 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_40 0327-0103 19.753 µM 1.97089001922364 0.0371175589033626 no 238 0.0243682284985091 255 409036
SGTC_2708 st078559 56 µM 1.97023248017724 0.0371652594349555 no 239 0.0244058663355158 134 17250902
SGTC_1356 1502-0781 85.8 µM 1.96938242694282 0.0372269999486258 no 240 0.0244545960904463 221 567702
SGTC_800 3448-7362 155 µM 1.96843045349987 0.037296242515574 no 241 0.0245092653969989 512 15991913
SGTC_123 0083-0120 66.675 µM 1.96326838087567 0.0376735444195054 no 242 0.0248074987163326 262 16001701
SGTC_1458 k015-0034 6.33 µM 1.95921031517414 0.0379723358289267 no 243 0.0250440808038199 206 3598957
SGTC_261 5-fluorouridine 15.376 µM 1.9580289372662 0.0380596819710112 no 244 0.0251133086349978 234 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_573 3702-0553 84.7 µM 1.94866071739873 0.0387581465833177 no 245 0.0256679779628484 206 1222756
SGTC_1770 st043884 66.3 µM 1.94547588923467 0.038997962200784 no 246 0.0258588644173872 220 670149
SGTC_2063 5246145 200 µM 1.94281015964797 0.039199617624414 no 247 0.026019549960275 257 711240
SGTC_1468 k284-1086 134 µM 1.94082691368243 0.0393501948768005 no 248 0.02613963767888 304 15996457
SGTC_563 tetrahydrosecaminediol 614 µM 1.93765110500134 0.0395922969621209 no 249 0.0263329015070667 245 334274 A psychoactive constituent of the cannabis plant.
SGTC_2570 licareol 100 µM 1.93048214701978 0.0401432645557614 no 250 0.0267735625947525 255 443158
SGTC_1177 0983-0204 23.6 µM 1.92738850289336 0.0403829416495523 no 251 0.0269656156785287 225 766818
SGTC_2884 9058502 51.95 µM 1.92335125381988 0.0406974699543081 no 252 0.0272179759051817 259 6471554
SGTC_3040 9091894 49.47 µM 1.92067764027194 0.0409068541605313 no 253 0.0273861801067842 180 25236966
SGTC_2008 4012253 172 µM 1.92010223184219 0.040952031387472 no 254 0.027422493725853 282 603940
SGTC_3 0833-0587 95.581 µM 1.9175388967478 0.041153779291465 no 255 0.0275847521837311 216 5382644
SGTC_3126 9127922 49.47 µM 1.91752736518962 0.0411546887030383 no 256 0.0275854839327304 276 45595682
SGTC_2866 9034245 58.44 µM 1.91192358081133 0.0415985507427754 no 257 0.0279429983063096 183 6462273
SGTC_1828 st055811 49 µM 1.91051336562987 0.0417108590880488 no 258 0.0280335735786087 186 5877589
SGTC_979 1426-2828 121 µM 1.90623690686995 0.0420529349244778 no 259 0.0283097379406617 287 747872
SGTC_3144 9087057 49.47 µM 1.89375016863483 0.0430647658027997 no 260 0.029129089396429 239 17249618
SGTC_1424 4048-1941 275 µM 1.89302223932215 0.0431243531979503 no 261 0.0291774560118007 278 X1424
SGTC_2692 st077426 47.7 µM 1.89243789317918 0.0431722352266414 no 262 0.029216330626901 264 25238571
SGTC_2308 7584454 197.62 µM 1.88979931025002 0.0433889788611746 no 263 0.0293924029282947 291 893577
SGTC_582 0987-0078 156 µM 1.88017712473133 0.044186836890552 no 264 0.030041971059809 387 1625765
SGTC_668 1682-0499 62.6 µM 1.87782872473608 0.044383347701945 no 265 0.0302022996783643 287 682214
SGTC_54 0159-0055 9 µM 1.87716668451493 0.0444388733677555 no 266 0.0302476260495547 246 3319099
SGTC_1313 1220-0047 237 µM 1.87511627710717 0.0446111973194228 no 267 0.0303883643679397 322 3528706
SGTC_37 0566-0070 1.56 µM 1.86972167987237 0.0450671514431951 no 268 0.0307612386470699 292 1626686
SGTC_152 4469-0003 551.229 µM 1.86835879964319 0.0451829342481882 no 269 0.0308560378978188 233 697280
SGTC_1259 0671-0132 43 µM 1.86693919504786 0.0453037904094619 no 270 0.0309550397882195 283 X1259
SGTC_1857 st056007 79.3 µM 1.86475423640441 0.045490311976347 no 271 0.0311079303154447 205 619834
SGTC_3210 9128157 49.47 µM 1.85897822069102 0.0459863634274971 no 272 0.0315151127674647 306 17590849
SGTC_1414 3917-0015 5.4 µM 1.85760562216103 0.0461048806883555 no 273 0.0316125197781422 217 6618702
SGTC_2746 daunorubicin 9.88 µM 1.85063741107736 0.0467103413059379 no 274 0.0321108669223753 131 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_999 SEC7.066 22.7 µM 1.84834679747981 0.0469107578015767 no 275 0.0322760949460088 305 740511 YDR170C SEC7
SGTC_3128 9127691 49.47 µM 1.84660844995622 0.047063313769805 no 276 0.0324019543229205 229 41316314
SGTC_2870 9038528 12.99 µM 1.84465139747411 0.047235538828072 no 277 0.0325441325979075 245 6463316
SGTC_1247 0448-0043 5.84 µM 1.84458423935785 0.0472414578476076 no 278 0.0325490206985069 335 3089013 YGL099W LSG1
SGTC_910 3454-3003 490 µM 1.84198540824062 0.047470964309317 no 279 0.032738642149836 301 820824
SGTC_599 1935-0052 86.5 µM 1.84193158246075 0.0474757271657605 no 280 0.0327425791082534 278 9557311
SGTC_1106 tegaserod maleate 11.7 µM 1.84150000740398 0.0475139295872146 no 281 0.0327741597518961 299 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1866 st057638 64 µM 1.84087525433536 0.0475692754801351 no 282 0.032819920744625 241 688802
SGTC_404 fumagillin 50 µM 1.83772105350008 0.0478494901425123 no 283 0.0330517599490553 289 12015870 A methionine aminopeptidase binder.
SGTC_127 0180-0333 59.125 µM 1.83743205341498 0.0478752304448572 no 284 0.0330730692717619 368 771601
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.82853750676231 0.0486728738586715 no 285 0.0337344609880018 293 5106787 A p450 inhibitor.
SGTC_1011 4112-3381 17.4 µM 1.8283388375569 0.0486908106345422 no 286 0.0337493572387429 295 2877139
SGTC_2359 9039622 200 µM 1.82768320633296 0.048750041550598 no 287 0.0337985549858923 267 6463596
SGTC_3107 9121808 49.47 µM 1.82714702228415 0.0487985241868009 no 288 0.0338388334111259 175 662681
SGTC_438 sphingosine 6.67 µM 1.82664074254793 0.0488443381896127 no 289 0.0338769016465259 228 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_87 0100-0052 35.5 µM 1.82622250261434 0.0488822112607898 no 290 0.0339083765501989 509 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1302 1159-0335 255 µM 1.82545895894014 0.048951413299332 no 291 0.0339658995383619 254 649284
SGTC_1980 st071811 45.7 µM 1.82382177752467 0.049100059348707 no 292 0.0340895102102441 262 4974850
SGTC_1723 st034307 2.5525 µM 1.82364464370207 0.0491161636066528 no 293 0.0341029063363004 282 867466
SGTC_26 0302-0163 425.158 µM 1.82155381491783 0.0493065718858276 no 294 0.0342613570718396 230 3100915
SGTC_1213 1315-0166 115 µM 1.82056909864047 0.0493964522739508 no 295 0.0343361918482408 237 768401
SGTC_2318 6029776 164 µM 1.81564305797074 0.0498480441241524 no 296 0.0347125720384269 301 818325
SGTC_3013 9080133 71.4286 µM 1.8151971015509 0.049889088946999 no 297 0.0347468124881864 312 17050193
SGTC_948 3448-0295 75.3 µM 1.8138132514255 0.0500166270151028 no 298 0.0348532408363345 311 678569
SGTC_1228 0124-0032 52.5 µM 1.81182112972677 0.0502006808294716 no 299 0.0350069195720423 291 X1228
SGTC_1911 st060208 74.3 µM 1.80695043809681 0.0506529621885201 no 300 0.0353850036054218 300 688783
SGTC_2307 7538926 6.34 µM 1.80615699368143 0.0507269460952744 no 301 0.0354469102086387 336 96582
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.80584022975129 0.0507565064463807 no 302 0.0354716497488032 322 6708561
SGTC_2773 thioridazine 9.09 µM 1.80392038798072 0.0509359593393748 no 303 0.0356218941634962 264 5452 An antipsychotic.
SGTC_41 0478-0632 82.643 µM 1.80390688414056 0.0509372233669186 no 304 0.0356229528016961 327 3750424
SGTC_1881 5652484 16 µM 1.79839592998854 0.0514551644487336 no 305 0.0360571436436844 303 2255129
SGTC_940 3232-1287 54.8 µM 1.79760216254422 0.0515301097035466 no 306 0.0361200377064296 281 1585493 YIL048W NEO1
SGTC_2154 5570129 200 µM 1.79593985703406 0.0516873410622474 no 307 0.0362520413429851 305 673366
SGTC_1086 cerivastatin 2.18 µM 1.79509417004423 0.0517674777209658 no 308 0.0363193487414266 234 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1486 3970-0793 4.53 µM 1.79061605647469 0.0521934676335595 no 309 0.0366774643083477 235 2844330
SGTC_2103 5378138 10 µM 1.78477703852558 0.0527530928361582 no 310 0.0371487445997385 307 244142
SGTC_1415 3966-0071 78.1 µM 1.77215188189724 0.0539793898442091 no 311 0.0381846743105156 257 2893185
SGTC_2408 sulbentine 18.36 µM 1.7676508140337 0.0544220017926228 no 312 0.0385596487367127 314 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1058 3448-5425 97.3 µM 1.76239172500237 0.0549427849093364 no 313 0.0390015678953533 290 7279705
SGTC_187 1488-2104 32.728 µM 1.75606550931325 0.0555744498375011 no 314 0.0395386117704813 321 2852859
SGTC_2025 5147754 141 µM 1.75456342937367 0.0557252696188756 no 315 0.0396670057205496 264 315777 YLR208W SEC13
SGTC_2463 5473429 200 µM 1.75337213349838 0.0558451139276104 no 316 0.0397690755380938 271 5399405
SGTC_254 nsc-64875 3.808 µM 1.75271363637888 0.0559114459209947 no 317 0.0398255869146505 271 56993
SGTC_1705 st027868 56.3335 µM 1.75237118621996 0.055945966304372 no 318 0.0398550013381988 260 292948
SGTC_2261 9010538 184.68 µM 1.75085821213296 0.0560986815764392 no 319 0.0399851682057126 245 6457250
SGTC_3093 9117344 49.47 µM 1.74677014305555 0.0565129640152757 no 320 0.0403386087980484 290 24824913
SGTC_2059 5238311 157 µM 1.74170983090107 0.057029107811804 no 321 0.0407796157021128 302 703021
SGTC_630 4356-0227 183 µM 1.73998043737472 0.057206351673454 no 322 0.0409312265296693 268 779312
SGTC_3112 9123419 49.47 µM 1.7380635365145 0.0574033192830787 no 323 0.041099809505504 329 17015854
SGTC_3295 9122362 53.5725 µM 1.73221257560227 0.0580078249884008 no 324 0.0416178603968697 294 4730473
SGTC_2960 9079389 5.97 µM 1.7320216973561 0.0580276299691012 no 325 0.0416348496734014 321 16457355
SGTC_1831 st055328 12 µM 1.73138538223075 0.0580936905922378 no 326 0.0416915260137814 310 1103068
SGTC_1625 st003711 30.1 µM 1.72997682200373 0.0582401339328693 no 327 0.0418172082063216 299 24207034 YER133W GLC7
SGTC_1245 0418-0076 17.2 µM 1.72736934893933 0.0585119894193338 no 328 0.0420506758668282 329 6790114
SGTC_1515 3460-0031 42.1 µM 1.72326894407589 0.0589415124476659 no 329 0.0424199505507353 257 2876596
SGTC_117 lucigenin 22.078 µM 1.72289472713632 0.0589808350523537 no 330 0.0424537820281564 406 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_520 3584-0023 682 µM 1.71105196044578 0.06023593349957 no 331 0.043535760619535 324 1340790
SGTC_2729 fluphenazine 10.66 µM 1.71087593422137 0.0602547452526208 no 332 0.0435520090390107 330 3372 An atypical antipsychotic.
SGTC_997 3996-0078 137 µM 1.71065955665721 0.0602778756148296 no 333 0.0435719888676206 339 735687
SGTC_2044 5102272 200 µM 1.7087889551553 0.060478129319923 no 334 0.0437450246743641 265 592666
SGTC_2129 girgensonine 121.053 µM 1.70722082201386 0.0606464036173017 no 335 0.04389050813717 361 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2430 5571206 200 µM 1.70615033460614 0.0607614863925484 no 336 0.0439900464945808 378 1731771
SGTC_1764 st044502 93.5 µM 1.70249435609268 0.0611558104601454 no 337 0.0443313677919308 337 8407
SGTC_2543 pimpinellin 60.67 µM 1.70204303415729 0.0612046272018769 no 338 0.0443736507041612 315 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2102 5377816 72.7585 µM 1.6999143913886 0.0614352801143938 no 339 0.0445735147553591 330 1379702
SGTC_1351 1496-0003 46.5 µM 1.69939693764843 0.0614914522016679 no 340 0.0446222092963458 316 3891978
SGTC_1155 4088-0394 48.2 µM 1.69530677387225 0.0619368718533817 no 341 0.0450086202338662 337 2326248
SGTC_1461 k072-0203 53.8 µM 1.69503578590754 0.0619664712041983 no 342 0.0450343161750193 311 5418714
SGTC_2376 9072922 81.32 µM 1.69419524576855 0.062058351566381 no 343 0.0451140939818937 366 17087968
SGTC_878 0828-0289 13.7 µM 1.68876513798284 0.0626544863599052 no 344 0.0456322235779138 407 745350 YLR208W SEC13
SGTC_3043 9092303 49.47 µM 1.67993529383556 0.063633373373675 no 345 0.0464849529683848 320 25236084
SGTC_1092 toremifene 6.32 µM 1.67892315088327 0.0637463367737186 no 346 0.0465835109859036 387 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_449 xestospongin c 11.1929 µM 1.67391282132597 0.0643078293129886 no 347 0.0470738670066101 365 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_396 dithiazanine 1.25 µM 1.67212561986133 0.0645090430351409 no 348 0.0472497767950255 278 10578 An antihelmenthic.
SGTC_2514 salinomycin 42.74 µM 1.66686019436756 0.0651046995400268 no 349 0.047771103795401 406 23682228 A polyether potassium ionophore.
SGTC_566 0958-0068 16.5 µM 1.6665062878025 0.0651448881529418 no 350 0.0478063084357078 280 6815365
SGTC_791 1348-1292 225 µM 1.66602548785962 0.065199517252097 no 351 0.0478541689938239 426 5437054
SGTC_1896 st058441 89 µM 1.6591171014655 0.0659883871582661 no 352 0.0485460989229441 307 688759
SGTC_2922 7999257 32.47 µM 1.65867044814658 0.066039644016819 no 353 0.0485911087085541 296 2988377
SGTC_1614 st002383 48.6 µM 1.65250606624511 0.0667502082218471 no 354 0.0492157147616119 344 1947235
SGTC_2433 5607874 27.82 µM 1.64946852712627 0.0671025121920918 no 355 0.0495258429024271 357 2252428
SGTC_163 TUB2.036 7.546 µM 1.64916149003624 0.0671382032539524 no 356 0.0495572775285939 538 15992207 YJR013W GPI14
SGTC_2231 micatex 6.853 µM 1.64222817197024 0.0679480706726902 no 357 0.0502713631871118 282 20737 An antifungal of unknown mechanism.
SGTC_314 1671-0008 2.74 µM 1.64170930246509 0.0680089808973398 no 358 0.0503251314420016 405 3913060
SGTC_417 st075190 100 µM 1.63236127799945 0.0691135834315659 no 359 0.0513017006540222 357 222757
SGTC_1913 st060213 96.1 µM 1.6243287772416 0.0700737373708353 no 360 0.0521528293340354 402 688959
SGTC_2642 cholecalciferol 100 µM 1.62262612589 0.0702785733832328 no 361 0.0523346760441738 313 9821465 A vitamin D precursor, similar to steriods.
SGTC_2983 9022671 12.99 µM 1.61971100485219 0.0706303431723566 no 362 0.0526471855554995 343 6405161
SGTC_333 3486-0131 40.1 µM 1.61360937502266 0.0713710099702009 no 363 0.0533060910288205 342 6744690
SGTC_530 4358-1714 28 µM 1.61238033690499 0.0715209196689444 no 364 0.0534396005091739 427 1564641
SGTC_2075 5212009 200 µM 1.61106860735095 0.071681181931942 no 365 0.0535823848677287 305 780898
SGTC_3189 9110682 49.47 µM 1.60963447989944 0.0718567134073329 no 366 0.0537388381503528 362 17122418
SGTC_849 0386-0493 241 µM 1.60890890647529 0.0719456461838929 no 367 0.053818130851431 342 726119
SGTC_355 1311-2252 105 µM 1.60840165686052 0.0720078693476251 no 368 0.0538736195180842 389 5338538
SGTC_3027 9089541 49.47 µM 1.60653088548 0.0722377093718352 no 369 0.054078657229233 391 9943819
SGTC_448 monastrol 171 µM 1.60331203448403 0.0726344877027667 no 370 0.0544328904252335 345 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_639 0833-0042 114 µM 1.6003186062038 0.0730049746876939 no 371 0.0547639606402169 401 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2748 diazoxide 86.69 µM 1.59717350187912 0.0733957904472709 no 372 0.0551135188067344 296 3019 A potassium channel activatior.
SGTC_2037 5169046 200 µM 1.59059221688318 0.0742187666685195 no 373 0.0558506886041 341 5718022
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.58980204651266 0.0743180478771773 no 374 0.0559397162214439 458 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2525 harmine 47.85 µM 1.58761540898844 0.0745933172722639 no 375 0.0561866658358203 296 5280953 A monoamine oxidase inhibitor
SGTC_440 fluspirilene 35.1 µM 1.58276302939032 0.0752069478605144 no 376 0.0567377430990955 395 3396 An atypical antipsychotic.
SGTC_2201 6605497 169.863 µM 1.58257741597805 0.0752304966797055 no 377 0.0567589071712468 335 670741
SGTC_539 4859-0462 2.54 µM 1.58195564372676 0.0753094220355444 no 378 0.0568298483932784 360 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1447 4239-0816 81.9 µM 1.57956675559326 0.0756132454227248 no 379 0.0571030587835137 364 1341554
SGTC_3115 9123671 49.47 µM 1.57907581531728 0.0756757996720008 no 380 0.0571593341052127 341 3286988
SGTC_2438 5259590 200 µM 1.57894780695102 0.0756921166213113 no 381 0.0571740145737769 384 1201127
SGTC_2523 spermine 47.74 µM 1.57789668381713 0.0758262023858064 no 382 0.0572946734869833 358 1103 A DNA binding polyamine.
SGTC_1036 k216-0215 33.5 µM 1.57533875283076 0.0761532587090062 no 383 0.0575891367227583 456 622330
SGTC_100 0086-0128 49.5915 µM 1.57332283557302 0.0764117690258888 no 384 0.0578220421729236 450 93297
SGTC_84 0443-0269 128.823 µM 1.57256743866435 0.0765088088149871 no 385 0.0579095061149771 401 6150058
SGTC_784 4579-0127 173 µM 1.55987462768613 0.0781534060568683 no 386 0.0593947556969639 402 1948547
SGTC_170 4197-0004 226 µM 1.55131133509395 0.0792780017831292 no 387 0.0604135458593542 329 218692
SGTC_3231 9132313 49.47 µM 1.53604981798555 0.0813125675864524 no 388 0.0622630812452145 392 4905967
SGTC_2938 9059746 27.26 µM 1.53541970355762 0.0813974092589645 no 389 0.062340383435965 370 6471769
SGTC_838 0109-0203 71.4 µM 1.53497264854392 0.0814576434003321 no 390 0.0623952733429955 396 759422
SGTC_3238 9133470 49.47 µM 1.53408471396565 0.0815773793135268 no 391 0.062504406683465 359 3534688
SGTC_2944 9067346 25.62 µM 1.53341947606536 0.0816671720197341 no 392 0.0625862665195544 435 6473075
SGTC_1066 ketoconazole 628 nM 1.52775994466176 0.0824341018760943 no 393 0.0632860753545682 458 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.52158218584645 0.0832774337307447 no 394 0.0640569019796001 415 94937 An inhibitor of serotonin biosynthesis.
SGTC_853 0419-0306 21 µM 1.51246051761036 0.0845344774115 no 395 0.0652083747530397 389 762713
SGTC_1695 st026914 34.495 µM 1.51203400207294 0.0845936013420412 no 396 0.0652626063867199 417 3289191
SGTC_786 4544-0069 423 µM 1.50663516189635 0.0853446762346833 no 397 0.065952099704777 438 748821 YLR208W SEC13
SGTC_571 k831-0106 44.2 µM 1.50259850388058 0.0859095030529508 no 398 0.0664713047189182 386 4783639
SGTC_1671 st016596 74.5 µM 1.50227616580205 0.0859547263330716 no 399 0.0665129006947497 440 2829167
SGTC_363 0455-0021 3.06 µM 1.49446932070421 0.087055455888329 no 400 0.0675264974160754 459 4597466
SGTC_1539 benzyladenosine 56 µM 1.49014177092576 0.0876701386010341 no 401 0.068093481534213 393 92208 A nucleotide analog.
SGTC_710 3448-4187 58 µM 1.49010072431265 0.0876759843011673 no 402 0.0680988768931441 531 3946412
SGTC_292 k038-0015 474 µM 1.4887397408348 0.0878699750261729 no 403 0.0682779578737376 391 46368540
SGTC_2638 epoxomicin 18 µM 1.48533974364533 0.0883559995297297 no 404 0.0687269244015707 451 9915668 A protesome inhibitor.
SGTC_1473 k844-0725 134 µM 1.48517883343965 0.0883790509517868 no 405 0.0687482287322795 470 54682906
SGTC_3255 9139072 49.47 µM 1.48235978702108 0.0887836247788084 no 406 0.0691222939417083 413 17646060
SGTC_929 2805-0021 398 µM 1.47895913678528 0.0892735004304907 no 407 0.0695756182394509 416 3098024
SGTC_2283 7944793 200 µM 1.47695750709439 0.0895627808915714 no 408 0.069843514076437 457 2970533
SGTC_1402 3909-7673 35.9 µM 1.47616697926305 0.0896772217387227 no 409 0.069949535833867 411 5328014
SGTC_376 3970-0862 59.1 µM 1.47526659611922 0.0898076981933024 no 410 0.0700704416515121 448 3135186
SGTC_2825 7998094 58.44 µM 1.47494517604725 0.0898543100278699 no 411 0.0701136417030096 423 2987815
SGTC_795 0685-0265 78 µM 1.47416213297158 0.0899679409652006 no 412 0.0702189713539497 468 302754
SGTC_1516 st013856 110 µM 1.47320180771643 0.090107443868008 no 413 0.0703483138988003 398 5281404 A mutagen and neurotoxin.
SGTC_2095 5432005 200 µM 1.46851874919586 0.09079003774512 no 414 0.0709816835735659 391 783734
SGTC_1521 st012942 49.4 µM 1.46638142689729 0.0911028420346838 no 415 0.0712722016698895 469 24207259
SGTC_1755 st041960 45.185 µM 1.46343658180155 0.0915351383381237 no 416 0.0716739774535758 425 2257073
SGTC_1334 1486-0610 236 µM 1.4549149005868 0.0927946632862767 no 417 0.0728464110771224 464 3742339
SGTC_750 4073-0104 132 µM 1.45214238022685 0.0932071990133964 no 418 0.0732310100381366 344 22330957
SGTC_2177 5811945 192 µM 1.45037959671916 0.093470195282907 no 419 0.0734763467886937 443 5343475
SGTC_2987 9018338 71.43 µM 1.44467247839392 0.0943254211188273 no 420 0.0742749519378 458 5055682
SGTC_2171 5739187 198.077 µM 1.44261514381418 0.0946351287241128 no 421 0.0745644574861071 387 2262761
SGTC_1792 st045773 43.6 µM 1.44073107239276 0.0949194105315269 no 422 0.0748303364852536 446 2919270
SGTC_1497 4476-2978 41.3 µM 1.43810144192118 0.0953172386443688 no 423 0.0752026367921317 504 1528379
SGTC_3341 9147222 25.867 µM 1.43738033878718 0.0954265461237693 no 424 0.07530497613948 433 1939759
SGTC_2943 9068529 45.32 µM 1.43265911428293 0.0961444872494367 no 425 0.0759776395803016 505 3270634
SGTC_2800 7887935 81.82 µM 1.43042847482468 0.096485071276787 no 426 0.0762970402850997 435 2961002
SGTC_2907 7721985 69.9 µM 1.42879435553594 0.0967351379122077 no 427 0.0765316741929701 457 3267881
SGTC_59 0330-0160 1.33 µM 1.41153380223488 0.099405609846339 no 428 0.0790436379635624 628 4293482
SGTC_1230 0170-0365 3.77 µM 1.41071624145847 0.0995334226169996 no 429 0.0791641500228501 634 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2295 7971645 200 µM 1.41008029959888 0.0996329251409844 no 430 0.0792579868118678 481 2978226 YKL099C UTP11
SGTC_1328 1441-0025 69.2 µM 1.40883047635799 0.0998286902562939 no 431 0.0794426505793985 424 4562601
SGTC_270 tamoxifen 5.46 µM 1.39880371267873 0.101409401544759 no 432 0.0809359263363869 515 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2603 homopterocarpin 100 µM 1.39670340863933 0.101742809831494 no 433 0.0812513893764151 525 101795 A weak amylase inhibitor.
SGTC_975 1335-0046 28.5 µM 1.39483201216567 0.102040552348982 no 434 0.0815332515098762 487 16486740
SGTC_1294 1000-1494 117 µM 1.39306032899459 0.102323014057721 no 435 0.0818007740820464 476 712797 YDL207W GLE1
SGTC_1797 st048695 56.8 µM 1.38808482812406 0.103119304496155 no 436 0.0825556079659942 496 592262 YIL048W NEO1
SGTC_1471 k673-0312 37 µM 1.38656826579715 0.103362911185494 no 437 0.0827867252967503 471 24099884
SGTC_1564 D-Arginine 115 µM 1.37607655922092 0.105059652253164 no 438 0.0843989659524314 497 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2805 7950783 58.44 µM 1.37094697566688 0.105896518649039 no 439 0.0851957430058384 565 1178958 YDL195W SEC31
SGTC_1970 st070122 35.8 µM 1.36997085350533 0.106056312314245 no 440 0.0853480000888076 506 102928
SGTC_2996 9066192 71.4286 µM 1.36944117018894 0.106143095695196 no 441 0.0854307062011668 516 6472854
SGTC_1756 st041558 35.5 µM 1.36513646936293 0.106850281514449 no 442 0.0861050807720438 545 3955792
SGTC_3065 9113888 49.47 µM 1.36504172532212 0.106865884418522 no 443 0.0861199680391868 454 16648368
SGTC_321 4534-3890 65.3 µM 1.36403682576652 0.107031477298832 no 444 0.0862779878889632 492 699746
SGTC_1223 0764-0573 147 µM 1.36145712413417 0.107457421933749 no 445 0.0866846371593614 546 1609797
SGTC_2203 7227154 166.4 µM 1.35749359539348 0.108114234022609 no 446 0.087312213548119 453 896304
SGTC_5 0352-0601 109.883 µM 1.35686814678758 0.108218143051226 no 447 0.0874115547773713 443 762456
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.35560622580801 0.108428011327754 no 448 0.0876122449513083 446 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.35350068923717 0.108778831752642 no 449 0.0879478649967624 518 5377381
SGTC_2348 9022543 33.42 µM 1.35250733038302 0.108944626353183 no 450 0.0881065376917183 524 3162678 YDL140C RPO21
SGTC_629 3448-6466 76.7 µM 1.35147296550077 0.109117457955278 no 451 0.0882719871401538 532 573744
SGTC_1722 st034304 3.6505 µM 1.34461861718149 0.110267728576343 no 452 0.0893742140323495 532 4036148 YLR033W RSC58
SGTC_2221 6807166 181.081 µM 1.34096381510405 0.110884606275765 no 453 0.089966100600239 423 674925
SGTC_46 0329-0187a 2.197 µM 1.33642936996097 0.111653386371237 no 454 0.0907044859681942 622 46494817
SGTC_2644 guaiazulene 100 µM 1.33520859275141 0.111861009663909 no 455 0.0909040426533194 490 3515 A coloring agent.
SGTC_538 2922-0838 53.3 µM 1.33443289569345 0.111993079469669 no 456 0.0910310125890017 609 777039
SGTC_712 r015-0009 80.6 µM 1.33405095121114 0.112058150099236 no 457 0.0910935794637187 458 6813872 YLR060W FRS1
SGTC_351 caspofungin 25 nM 1.32971857857849 0.112798134869029 no 458 0.0918055056119241 673 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.32814109001741 0.113068440107839 no 459 0.0920657506488947 489 6708514
SGTC_3039 9090270 49.47 µM 1.32483821394188 0.113635889707238 no 460 0.0926124086167562 481 17173750
SGTC_2331 7980721 200 µM 1.32375089123949 0.113823140291295 no 461 0.0927928953347057 539 2981221
SGTC_2187 6125751 200 µM 1.32018439959181 0.114438878061239 no 462 0.0933867296174082 542 874498
SGTC_2469 5655019 90.81 µM 1.31698233274499 0.114993716569459 no 463 0.093922273324362 562 2788239
SGTC_3084 9116877 49.47 µM 1.31532104139299 0.115282329603984 no 464 0.0942010147106628 439 27241325
SGTC_1923 st058458 19.1 µM 1.31500603578218 0.115337112959984 no 465 0.0942539369870487 592 3534982
SGTC_2480 5767542 37.17 µM 1.31395665698936 0.115519746342415 no 466 0.0944303952781464 529 2867358
SGTC_1834 st055981 52.8 µM 1.31387211517666 0.115534468897868 no 467 0.094444622002561 538 471719 YDL150W RPC53
SGTC_2678 equilin 100 µM 1.31386828468453 0.115535135991461 no 468 0.0944452666364765 541 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_74 000s-0487 160.283 µM 1.31252395311104 0.11576942507707 no 469 0.0946717047538528 530 677548
SGTC_3218 9131285 49.47 µM 1.31062156698901 0.116101547779406 no 470 0.0949928245511709 616 17156417
SGTC_15 0266-0086 27.098 µM 1.3092900186911 0.116334414351725 no 471 0.0952180646880298 643 1712902 YIL048W NEO1
SGTC_3237 9133362 49.47 µM 1.3085163349354 0.116469871419623 no 472 0.0953491188813568 514 43845137
SGTC_1768 st044301 37.178 µM 1.30682932891922 0.116765621392643 no 473 0.0956353409811224 554 3931349
SGTC_1851 st056236 18.9 µM 1.29933498456902 0.11808589436176 no 474 0.0969144966110469 546 5393171
SGTC_1070 indatraline 8.81 µM 1.29882582673828 0.118175973809394 no 475 0.097001854607081 567 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2397 5161689 200 µM 1.29557072069626 0.11875301076477 no 476 0.0975617109497362 581 2259942
SGTC_1445 4239-0156 97.7 µM 1.29386292846205 0.119056548170399 no 477 0.0978563857703257 622 4008346
SGTC_645 0845-0943 5.41 µM 1.28345736627075 0.120917836921151 no 478 0.0996659434667845 548 1885106
SGTC_3205 9113483 49.47 µM 1.28226138871939 0.121133071517775 no 479 0.0998754838705069 597 17018033
SGTC_2848 9016370 25.97 µM 1.28159670334149 0.121252808338023 no 480 0.0999920786210554 630 7894410
SGTC_856 0433-0016 11.3 µM 1.28021266226535 0.121502397367257 no 481 0.100235176931133 589 3911780
SGTC_2775 cyproheptadine 69.59 µM 1.27787305905457 0.121925127102293 no 482 0.100647094361721 565 2913 A selective serotonin reuptake inhibitor.
SGTC_1871 st057448 67.3 µM 1.27699153834049 0.122084671758971 no 483 0.100802617317857 588 691747
SGTC_1339 1486-1321 22.7 µM 1.27692282443781 0.122097114305958 no 484 0.100814747578281 575 3469382
SGTC_1898 st060199 18.6 µM 1.27520903998271 0.122407730336019 no 485 0.101117631231132 525 688866
SGTC_532 1548-0774 215 µM 1.27409242610243 0.122610409914066 no 486 0.1013153311495 584 5932993
SGTC_2312 7706453 155.7 µM 1.27113744736932 0.123147911576975 no 487 0.101839877626805 556 976098
SGTC_3274 9138298 49.47 µM 1.27045805702966 0.123271723760218 no 488 0.101960757086938 591 17015756
SGTC_650 1328-0195 38 µM 1.27041669844073 0.123279263770363 no 489 0.10196811911918 585 2780821
SGTC_1426 4048-4480 71.7 µM 1.26945030275066 0.123455537634968 no 490 0.102140252442142 585 14224343
SGTC_2233 sulbentine 40.3845 µM 1.26672894544567 0.123952870823617 no 491 0.102626113187699 627 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1610 st001799 48.1 µM 1.26617608107212 0.124054078955272 no 492 0.102725024459712 499 621897
SGTC_745 0469-0705 296 µM 1.26405378386656 0.124443126631578 no 493 0.103105361592844 648 3486736
SGTC_485 niflumic acid 177 µM 1.26369146320798 0.124509630394866 no 494 0.10317039519436 536 4488 A COX2 inhibitor.
SGTC_953 1188-0045 9.7 µM 1.26070773107949 0.12505823774515 no 495 0.103707083754263 584 6144426
SGTC_168 3970-0862 530.542 µM 1.25622248835646 0.125886094788166 no 496 0.104517657748676 755 3135186
SGTC_283 0987-0079 11.7 µM 1.25521735971393 0.126072137933705 no 497 0.104699932658705 615 411556
SGTC_665 3914-0008 307 µM 1.25340126131296 0.126408772482165 no 498 0.10502985634221 577 1069549
SGTC_1973 st070275 50.2 µM 1.23443193952523 0.129962406887204 no 499 0.108520996758711 546 17118334
SGTC_1786 berberine 21.6 µM 1.23385362266151 0.130071821990716 no 500 0.108628726877291 595 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2211 7117706 200 µM 1.23367937867169 0.130104800710881 no 501 0.108661200499509 559 822771
SGTC_2745 rifampicin 24.3 µM 1.23320069916571 0.130195428955749 no 502 0.108750447301736 448 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.23264894023607 0.130299947489346 no 503 0.108853384687388 586 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3314 9135860 59.4275 µM 1.23225545914381 0.130374519234348 no 504 0.108926836183711 614 25252478
SGTC_2292 7671323 168.05 µM 1.23088375506221 0.130634712646478 no 505 0.109183172100633 590 937504
SGTC_2760 etidronate 98.04 µM 1.220202986325 0.132672989466641 no 506 0.111193967542614 584 3305 A chelator and antioxidant.
SGTC_3044 9093193 49.47 µM 1.21180717506994 0.134290515262424 no 507 0.112793100556226 614 25236277
SGTC_1830 st055982 50.3 µM 1.20791965189423 0.135044048957989 no 508 0.113539084843432 607 455313 An antimicrobial agent.
SGTC_3017 9080681 49.47 µM 1.20764230475627 0.135097918829387 no 509 0.11359243964365 603 16451914
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.20763174346525 0.135099970468211 no 510 0.11359447173077 564 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2499 avocadenofuran 51.48 µM 1.20730141471741 0.135164150991554 no 511 0.113658043027754 611 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3193 9111931 49.47 µM 1.20584816436858 0.135446755458664 no 512 0.113938020205599 621 17087244
SGTC_2117 5521686 200 µM 1.20567196250246 0.135481047832972 no 513 0.113971999899446 610 803312
SGTC_1136 pergolide 1.05886 µM 1.20479968696723 0.135650897558615 no 514 0.114140320439711 710 47811 A dopamine receptor agonist.
SGTC_757 1066-0008 322 µM 1.20442255363452 0.135724378210633 no 515 0.114213149589665 652 6842497
SGTC_3149 9097855 49.47 µM 1.20298083542129 0.136005533859914 no 516 0.114491868422444 598 25236625 YMR079W SEC14
SGTC_462 ag-879 158 µM 1.20258296944631 0.136083193558304 no 517 0.114568870663005 660 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1115 galangin 695.678 nM 1.19971439467041 0.136644010687162 no 518 0.115125140298177 676 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2488 5268135 45.7 µM 1.19824941046027 0.136931029388667 no 519 0.115409967431903 714 1270356 YLR208W SEC13
SGTC_2942 9052777 62.25 µM 1.19519784077073 0.1375302130257 no 520 0.116004870990454 683 6469503
SGTC_1507 4075-3230 155 µM 1.19223789843377 0.138113113064494 no 521 0.116583988559435 560 659771
SGTC_1435 4092-0789 56.7 µM 1.19032430305855 0.138490851877105 no 522 0.11695947612158 639 2248285
SGTC_519 k048-0011 62.8 µM 1.18797652945225 0.138955257257883 no 523 0.117421328338055 613 6836379
SGTC_3336 9143619 71.43 µM 1.18513645749846 0.139518458158361 no 524 0.117981749241364 682 45595730
SGTC_2976 9009005 19.48 µM 1.18452731338493 0.139639456497714 no 525 0.118102195426163 624 2993148
SGTC_1160 4092-0570 10.5 µM 1.18020570266996 0.14049993535544 no 526 0.118959205745094 665 4994975
SGTC_1280 0880-0253 10.1 µM 1.18006489020448 0.140528033046653 no 527 0.118987203680759 655 6836607
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.17177981317561 0.142187952479425 no 528 0.120642734710472 673 2333 A French combination drug.
SGTC_278 4092-0821 23.9 µM 1.16703864961258 0.143143792641739 no 529 0.12159738081228 647 877900
SGTC_1676 st018489 23.4 µM 1.16671769857126 0.143208654327097 no 530 0.121662196503597 648 3696235
SGTC_2558 carylophyllene oxide 100 µM 1.16639765316486 0.143273352755204 no 531 0.121726853475716 695 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2020 4017018 200 µM 1.16311046938442 0.143939012348707 no 532 0.122392342469309 636 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1272 0839-0021 27 µM 1.16305967979565 0.14394931365379 no 533 0.122402644792369 673 5027250
SGTC_93 0109-0045 59.227 µM 1.16299315049045 0.143962808090232 no 534 0.122416140730703 751 88733
SGTC_707 0865-0008 204 µM 1.16091891296223 0.144383962975951 no 535 0.122837438354411 671 723043
SGTC_1633 st005664 67.9 µM 1.15741913514395 0.145096441451765 no 536 0.123550579951434 671 2063822
SGTC_2252 omeprazole 400 µM 1.15622727374723 0.145339617674144 no 537 0.123794103363639 550 4594 A proton pump inhibitor.
SGTC_1109 tnp00067 928.257 nM 1.15407971741107 0.145778476651801 no 538 0.124233743982899 664 676295
SGTC_2556 citropten 84.59 µM 1.15182089471382 0.146241033406058 no 539 0.124697339925176 695 2775 A potential DNA crosslinker.
SGTC_2680 butyl paraben 22.24 µM 1.15107844004554 0.146393286644659 no 540 0.12484998342286 633 7184 An antifungal and steroid mimetic.
SGTC_607 4491-0986 66.8 µM 1.14945632494746 0.14672629968355 no 541 0.125183933051567 684 698981 YDR232W HEM1
SGTC_1901 st060216 58.6 µM 1.14858731252194 0.146904913006964 no 542 0.125363095572253 672 688792
SGTC_616 4092-0450 108 µM 1.14723912186137 0.147182303218485 no 543 0.125641403411041 696 787165
SGTC_2900 5328528 85.29 µM 1.14218860811219 0.148224566204072 no 544 0.126687815077648 709 795359
SGTC_578 3460-0051 92 µM 1.13716223675256 0.149266738208842 no 545 0.127735235154811 756 2876744
SGTC_1298 1079-1278 263 µM 1.13627818696108 0.149450542546239 no 546 0.127920078455444 709 2840950
SGTC_3046 9092212 49.47 µM 1.13380542069147 0.149965461660837 no 547 0.128438088349306 666 25236637
SGTC_1167 k781-0610 148 µM 1.13227441872728 0.150284863770139 no 548 0.128759540738554 722 4525169
SGTC_124 0136-0217 7.121 µM 1.13041017455025 0.150674399512025 no 549 0.129151714415137 779 3976905
SGTC_3094 9117742 49.47 µM 1.12712895885105 0.151361644679471 no 550 0.129843980567641 712 17149698
SGTC_2212 7123476 200 µM 1.12183911967494 0.15247397556461 no 551 0.130965424905392 587 1085715
SGTC_1983 st071813 46.9 µM 1.12146538718601 0.152552767511046 no 552 0.131044908437007 691 11838595
SGTC_1419 3993-2473 62.6 µM 1.12136304963399 0.152574347479959 no 553 0.131066678880034 708 704026
SGTC_565 1418-0001 44.5 µM 1.12131834474984 0.152583775056028 no 554 0.131076189810835 734 2862145
SGTC_2751 anetholtrithion 17.25 µM 1.12061347973914 0.152732471389686 no 555 0.131226212342543 676 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.11660469805513 0.153579979901588 no 556 0.132081690997682 667 107982 A Capsaicinoid.
SGTC_2139 5578692 56.4705 µM 1.1149206608953 0.153936934362474 no 557 0.132442211049798 635 650991 YMR113W FOL3
SGTC_493 zm226600 134 µM 1.11487963637869 0.153945636908347 no 558 0.132451002064562 698 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1344 1488-0097 29.1 µM 1.11438166380503 0.154051297974051 no 559 0.132557743106122 665 747966
SGTC_620 0109-0052 432 µM 1.11232899141595 0.154487345527475 no 560 0.13299836154973 718 493037
SGTC_537 1334-0398 209 µM 1.1105790239715 0.154859733367663 no 561 0.133374797891804 727 5846986
SGTC_327 1273-0057 3.96 µM 1.10930557248031 0.155131092464735 no 562 0.133649190987075 662 3108138
SGTC_1681 tripelennamine 100 µM 1.10912424772887 0.15516975637585 no 563 0.133688292933215 616 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1725 st036284 20.55 µM 1.10855054439698 0.15529212914773 no 564 0.133812061534529 762 707914
SGTC_3168 9103419 49.47 µM 1.10565411842481 0.155910918457278 no 565 0.134438128032406 603 16649256
SGTC_758 0868-0029 16 µM 1.10520925375101 0.156006102661334 no 566 0.134534464024093 703 762687
SGTC_1484 3473-2379 286 µM 1.1034873605759 0.1563748835775 no 567 0.134907788723907 808 671917
SGTC_179 1273-0063 6.77 µM 1.10217355984385 0.156656648460775 no 568 0.135193112190742 638 3108139
SGTC_1776 st049249 45.9 µM 1.09899336550991 0.157340073021768 no 569 0.135885479883128 708 1822314
SGTC_1634 st006576 41 µM 1.09885139559456 0.157370628024312 no 570 0.13591644500404 705 3915356
SGTC_3310 9130229 44.1445 µM 1.09738538887813 0.15768637251482 no 571 0.136236478910364 692 7761258
SGTC_2540 epiandrosterone 100 µM 1.09624313742806 0.157932675741466 no 572 0.136486193160287 841 441302 A steroid.
SGTC_1255 0566-0045 221 µM 1.09305054688537 0.158622431784115 no 573 0.137185803585729 710 2788469
SGTC_1352 1496-0991 99 µM 1.09194500286601 0.15886174323535 no 574 0.137428637711585 709 3000039
SGTC_3160 9100216 49.47 µM 1.0896846341406 0.15935176980126 no 575 0.137926043542893 718 17191039
SGTC_394 menadione 8.33 µM 1.08965954584036 0.159357214255216 no 576 0.137931571235324 741 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2370 9071495 200 µM 1.08956339520198 0.159378081193789 no 577 0.137952757455951 676 21791103
SGTC_2925 9010536 32.5 µM 1.08750492387491 0.15982524676463 no 578 0.138406861844924 781 2994177
SGTC_2667 digitoxin 100 µM 1.08614769054342 0.160120529630663 no 579 0.138706827912839 631 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1689 st020265 53.493 µM 1.08432420673438 0.160517812196205 no 580 0.139110538030738 727 5758320 YPR016C TIF6
SGTC_1938 st074717 56.4 µM 1.08247347162675 0.16092168989549 no 581 0.139521098475136 655 17250979
SGTC_2868 9035608 32.47 µM 1.07959735069829 0.16155064823963 no 582 0.140160760857899 712 6462614
SGTC_676 falcarinol 140 µM 1.07846531722566 0.161798643507203 no 583 0.140413075778827 751 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_987 1497-1013 404 µM 1.07788146323391 0.161926645674875 no 584 0.140543329399334 706 1676435
SGTC_691 1548-0686 185 µM 1.07675189463103 0.162174475688223 no 585 0.140795560802685 736 46495133
SGTC_2932 9016711 44.54 µM 1.07666508341832 0.162193532487634 no 586 0.140814958350828 774 7117328
SGTC_3335 9143315 29.6265 µM 1.07655606112824 0.162217467128549 no 587 0.140839321425727 705 4899691
SGTC_233 rapamycin 362 pM 1.07652208177771 0.162224927390091 no 588 0.140846915333242 763 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2056 5235370 200 µM 1.07594193180637 0.162352335405338 no 589 0.140976613563222 689 5511916
SGTC_533 1222-0222 6.71 µM 1.07329456757388 0.162934555406865 no 590 0.141569485913835 789 3982874
SGTC_332 4112-0506 40.9 µM 1.07177947671102 0.163268370861602 no 591 0.141909546685174 729 2790355
SGTC_1791 st048313 56.1 µM 1.07104174226594 0.163431074441539 no 592 0.142075330571808 671 1204976
SGTC_3140 9094243 49.47 µM 1.07090193573329 0.163461919927216 no 593 0.142106762703883 756 19291112
SGTC_2178 5812956 200 µM 1.06949015269206 0.163773613175899 no 594 0.142424431857916 711 5403383
SGTC_3096 9117468 49.47 µM 1.06669261802148 0.164392391290101 no 595 0.143055330830262 627 41316311
SGTC_1192 1488-0095 21.4 µM 1.06585624022205 0.164577681043519 no 596 0.143244316523658 712 915875
SGTC_1578 josamycin 24.2 µM 1.06495100078807 0.164778378740455 no 597 0.143449051943524 666 5282165 A P450 substrate.
SGTC_1730 st033808 45.1 µM 1.06134716228266 0.165578945280159 no 598 0.144266079938967 817 1045166
SGTC_583 1488-1091 88.9 µM 1.06111542594383 0.165630509759169 no 599 0.144318724124281 870 4303273
SGTC_1172 0370-0043 85 µM 1.06061683946369 0.165741487216768 no 600 0.144432033288285 732 376585
SGTC_1501 4491-0275 38.4 µM 1.05849283320605 0.166214795877502 no 601 0.144915408212318 761 5104718
SGTC_492 tmb-8 126 µM 1.05812303673675 0.166297289615083 no 602 0.144999676566238 580 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1520 flindersine 88 µM 1.05640382086498 0.166681157300129 no 603 0.145391880553344 765 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2693 st077581 40.7 µM 1.05375771445931 0.167273098127507 no 604 0.145996928886482 839 25238761
SGTC_476 mead acid 10 µM 1.05347266105362 0.167336946055196 no 605 0.146062208875103 682 5312531 An omega 9 fatty acid.
SGTC_2264 7948757 110.76 µM 1.05144913748233 0.167790638089224 no 606 0.146526178982271 710 2971411
SGTC_186 3455-3465 67.277 µM 1.0504839149087 0.16800732833571 no 607 0.146747841242307 673 755278
SGTC_1007 4101-0031 70 µM 1.04820962544238 0.168518612873292 no 608 0.147271018392836 783 1146276
SGTC_972 1319-0219 195 µM 1.0465351012943 0.168895702519079 no 609 0.147657023792277 743 23903702
SGTC_454 lyso-paf C-16 6.67 µM 1.04525027983447 0.169185401434703 no 610 0.147953655331244 739 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_656 4090-1979 187 µM 1.04329986296429 0.169625786834143 no 611 0.148404717274737 809 22330961
SGTC_3105 9121040 49.47 µM 1.04142901848706 0.17004889586786 no 612 0.148838240281001 529 41448907
SGTC_890 0929-0006 47.2 µM 1.04092518398909 0.170162958284151 no 613 0.148955136254827 731 1378169
SGTC_1666 st014829 29 µM 1.03892492859125 0.170616276962914 no 614 0.149419825814642 788 3858230
SGTC_85 0868-0259 160.055 µM 1.03855353820103 0.170700530339505 no 615 0.149506211816217 733 83173
SGTC_2427 5545055 42.75 µM 1.03738025021085 0.170966876599789 no 616 0.149779339439074 825 5372858
SGTC_1237 0330-0133 46.1 µM 1.03434876734876 0.17165627889267 no 617 0.150486573042744 739 X1237 YHR072W ERG7
SGTC_2917 7979103 53.79 µM 1.03387114585153 0.171765058533798 no 618 0.150598202876112 822 2980565
SGTC_2290 7904846 200 µM 1.03191922552997 0.172210071397668 no 619 0.151054979367059 757 2962154
SGTC_801 0866-0028 10.1 µM 1.03158612757091 0.172286086895522 no 620 0.151133020910443 800 6849771
SGTC_134 0269-0018 6.916 µM 1.02650514533244 0.173448258868013 no 621 0.152326769780388 761 4378915
SGTC_1267 0828-0272 9.49 µM 1.02551528375308 0.173675249115679 no 622 0.152560058797878 814 745334
SGTC_14 0354-0009 295 µM 1.02430073793057 0.173954020947076 no 623 0.152846624756524 806 1713507
SGTC_688 0527-0193 473 µM 1.01855282205422 0.175277183034391 no 624 0.154207655790572 765 4007154
SGTC_1077 5-fluorocytosine 377 nM 1.01762199042169 0.175492058059582 no 625 0.154428816338686 765 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1399 3562-5772 25 µM 1.01757450843952 0.175503023368596 no 626 0.154440103418413 701 23847490
SGTC_1374 2889-5571 141 µM 1.01530516829048 0.176027602479077 no 627 0.154980190768761 812 2853281
SGTC_467 ro 31-8220 72.8 µM 1.01326456999285 0.176500152541574 no 628 0.155466902928651 802 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1675 st018485 24.5 µM 1.00813900007633 0.177690637593558 no 629 0.156693868570126 790 3323024
SGTC_2796 7949634 45.45 µM 1.00785286206173 0.177757246111376 no 630 0.156762551990147 745 2971588
SGTC_2017 5132927 60.65 µM 1.0072625277536 0.177894716600559 no 631 0.15690431606244 782 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1063 disulfiram 1.84 µM 1.00592506755574 0.178206417418353 no 632 0.157225808380958 768 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_182 3448-4371 550.524 µM 1.00405630206195 0.178642517321287 no 633 0.157675738220318 855 3491403
SGTC_1336 1486-0901 104 µM 0.996616334650447 0.1803853828375 no 634 0.159475387069518 805 5006114
SGTC_932 2857-0803 154 µM 0.995411802864116 0.180668553134784 no 635 0.15976801023748 858 674898
SGTC_1108 betulinic acid 729.144 nM 0.994648041744904 0.18084824810254 no 636 0.159953736570519 816 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2180 6301957 200 µM 0.993348734846454 0.181154201645427 no 637 0.160270017651255 840 845462
SGTC_1190 1486-1332 13 µM 0.992626709849577 0.181324360128156 no 638 0.160445951650098 809 4150046
SGTC_1759 st043059 70 µM 0.988066996402948 0.182401250940248 no 639 0.161559918948882 821 669426
SGTC_3265 9137266 49.47 µM 0.982465024604571 0.18372975485568 no 640 0.162935402737411 798 17224265
SGTC_2626 ethyl orsellinate 100 µM 0.98189347777681 0.183865634875635 no 641 0.163076164642096 781 75653 A natural product.
SGTC_1233 0325-0408 14.2 µM 0.980570517196459 0.184180396655678 no 642 0.16340228963303 821 12874
SGTC_1806 st050005 60.3 µM 0.980095125391062 0.184293584813 no 643 0.163519582572722 791 5194765
SGTC_558 k064-0027 21.3 µM 0.979907734505407 0.184338213436552 no 644 0.163565832356933 846 5088526
SGTC_823 0417-1665 178 µM 0.978171493471839 0.184752032705268 no 645 0.163994756426183 838 3429856
SGTC_1220 1838-0075 193 µM 0.977450266214523 0.184924101133234 no 646 0.164173144022879 842 5529645
SGTC_3158 9100007 49.47 µM 0.976345846023439 0.185187783618212 no 647 0.16444655397385 743 19297233
SGTC_1765 st044815 90.4 µM 0.973654039339869 0.185831435257399 no 648 0.165114172461766 815 645695
SGTC_1204 4049-0315 18.3 µM 0.973167515609428 0.185947918310156 no 649 0.165235026421674 808 588402
SGTC_1117 retinoic acid 1.10837 µM 0.971755344903513 0.186286275227083 no 650 0.165586138032646 892 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_613 3914-0030 117 µM 0.968540401396382 0.187057999230622 no 651 0.16638727590572 613 1145395
SGTC_1475 4092-1048 11.7 µM 0.967659062154167 0.18726990325394 no 652 0.166607334871386 866 2881759
SGTC_1978 st071761 42 µM 0.963564388124213 0.188256347960388 no 653 0.167632184122697 804 5147680
SGTC_2854 9024559 71.43 µM 0.962725680346718 0.188458795280675 no 654 0.167842602881229 798 3163529
SGTC_1382 3002-2117 298 µM 0.961992249823213 0.188635940771576 no 655 0.168026748518281 906 1497314
SGTC_526 4469-0568 170 µM 0.95906131071578 0.189344874793115 no 656 0.168763929742502 817 2901964
SGTC_210 3551-0445 56.827 µM 0.957027353143441 0.189837810015641 no 657 0.169276724508494 846 2865180 YOR207C RET1
SGTC_819 1013-0258 27.7 µM 0.9552708851994 0.190264129184667 no 658 0.169720363481743 834 5753198
SGTC_1867 st057372 64 µM 0.954983682250447 0.190333893234068 no 659 0.169792974487697 834 688837
SGTC_463 ikarugamyin 104 µM 0.954697559089368 0.190403410615165 no 660 0.169865332306206 839 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1188 1403-0014 4.57 µM 0.951779533680207 0.191113273341731 no 661 0.170604401839815 893 9614867
SGTC_2874 9043904 71.43 µM 0.951637939942544 0.191147759824979 no 662 0.170640316610896 766 4463428
SGTC_3016 9080866 49.47 µM 0.950695443071395 0.191377410995849 no 663 0.17087950106418 868 17066299
SGTC_508 roscovitine 141 µM 0.949756266666074 0.191606421209744 no 664 0.171118056138262 880 160355 A CDKinase inhibitor.
SGTC_3272 9137413 49.47 µM 0.94740727521441 0.192179937403964 no 665 0.171715642672917 822 17614870
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.946362539337677 0.192435351136227 no 666 0.171981852635701 1064 16725076
SGTC_1248 0469-0687 58.6 µM 0.946342036069243 0.192440365786302 no 667 0.1719870797243 871 4017482
SGTC_1052 3253-3998 198 µM 0.945842820662519 0.192562487587181 no 668 0.172114380640614 899 5450317
SGTC_1702 st027038 51 µM 0.943926921579793 0.193031608723239 no 669 0.17260349681021 863 5521182
SGTC_2320 7373003 200 µM 0.943556216050713 0.193122459046718 no 670 0.172698237674205 841 5415828
SGTC_621 3584-0052 32.1 µM 0.93940329398876 0.19414201604074 no 671 0.173761861220435 901 2273927
SGTC_699 0375-0592 111 µM 0.937921927009117 0.19450648875729 no 672 0.174142266908386 913 762578
SGTC_914 3820-6779 408 µM 0.937731655604877 0.194553332934287 no 673 0.174191165735835 853 2893481
SGTC_1120 ficusin 1.78878 µM 0.93690768902934 0.194756269953956 no 674 0.174403021851535 882 6199 A DNA cross-linker.
SGTC_1193 1488-0126 41.5 µM 0.935916632492395 0.195000530536602 no 675 0.174658056440114 882 1384710
SGTC_21 0849-0113 22.993 µM 0.933925291218429 0.195491888904285 no 676 0.175171215851954 869 1560156
SGTC_2341 7987486 176.74 µM 0.932241460322893 0.195907956031074 no 677 0.175605876640253 903 1258686
SGTC_1646 st011709 75.6 µM 0.931985880207353 0.195971155674193 no 678 0.17567191127964 838 5757843
SGTC_3047 9092122 49.47 µM 0.929784648608498 0.196515986295117 no 679 0.176241298113915 830 17173831
SGTC_926 2268-1401 59.4 µM 0.929029489193704 0.196703108345367 no 680 0.176436901992404 874 2931578
SGTC_91 0417-1751 58.384 µM 0.928737691141036 0.196775442307074 no 681 0.176512521256501 992 6795624
SGTC_2643 anethole 100 µM 0.924526819917747 0.197821069794407 no 682 0.177606047173215 927 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1251 0490-5699 265 µM 0.921027959145718 0.198692441928412 no 683 0.178517914985162 963 3883818
SGTC_358 0075-0058 9.45 µM 0.919987742975771 0.198951947744931 no 684 0.178789582224954 947 1069125
SGTC_1265 0819-1001 68.8 µM 0.916532244926275 0.199815466258314 no 685 0.179693901573437 856 3106768
SGTC_220 paclitaxel 373.376 µM 0.916454561294334 0.199834905037287 no 686 0.17971426470452 820 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2192 5915882 198.485 µM 0.915624819350371 0.200042602350739 no 687 0.179931854549721 874 2876149
SGTC_3240 9133527 49.47 µM 0.911584312167919 0.201055857425887 no 688 0.18099379189838 869 17617455
SGTC_2902 5787006 60.46 µM 0.908818475655222 0.20175122947169 no 689 0.181722976209823 867 591003
SGTC_2701 st077767 14.721 µM 0.908358846269827 0.201866926473342 no 690 0.181844330619336 922 5721188
SGTC_112 phenothiazine 287.218 µM 0.907829672257151 0.202000178293109 no 691 0.181984109422694 944 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2561 acetosyringone 100 µM 0.906304990890692 0.202384404038992 no 692 0.182387222295772 1003 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2565 isoliquiritigenin 100 µM 0.904263740335434 0.202899490947231 no 693 0.18292778436137 731 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_307 1501-1223 22.3 µM 0.902920837250243 0.203238784249238 no 694 0.183283955368213 891 2830329
SGTC_3225 9130819 49.47 µM 0.90044357259319 0.203865569278101 no 695 0.183942120782505 923 4547121
SGTC_2774 tamoxifen 10.92 µM 0.899391784819691 0.204132035351839 no 696 0.184222006727404 909 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3077 9117319 49.47 µM 0.89765769748297 0.20457181188233 no 697 0.18468403431869 890 17154678
SGTC_338 4055-0136 114 µM 0.89644092123128 0.204880731048816 no 698 0.185008660057793 919 2900563
SGTC_704 1310-0270 142 µM 0.896210165579478 0.20493934732899 no 699 0.185070263705989 941 5718033
SGTC_3154 9100113 49.47 µM 0.893047223553976 0.205743798634712 no 700 0.185915942005941 915 25237525
SGTC_648 0375-0473 33.3 µM 0.892434650677781 0.205899814543348 no 701 0.186080002658167 936 1713139
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.892066351143257 0.205993650358519 no 702 0.18617868465699 956 6708739 YPR165W RHO1
SGTC_2106 5357045 167.29 µM 0.890504907913196 0.206391758428618 no 703 0.186597417131036 925 668842
SGTC_330 1488-0319 80.1 µM 0.889952633108716 0.206532676367992 no 704 0.186745660245126 902 6846614
SGTC_249 wiskostatin 11.211 µM 0.888964846970989 0.206784861067515 no 705 0.187010986242237 938 2775510 A n-wasp and actin depolymerizer.
SGTC_1988 st071872 53.4 µM 0.888584568179516 0.206881995937792 no 706 0.187113193825026 949 16414116
SGTC_983 1491-0821 12.2 µM 0.88345599088961 0.208194627975313 no 707 0.188494975247646 942 46495113
SGTC_1802 st050112 57.9 µM 0.882265643627706 0.208499992237138 no 708 0.188816585431402 969 4662563
SGTC_265 mycophenolic acid 32.932 µM 0.881898636303977 0.208594195246997 no 709 0.188915812298792 976 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.881758696113168 0.20863012153801 no 710 0.188953656043131 956 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1870 st057514 26.5 µM 0.879904690073419 0.20910643734278 no 711 0.189455471884599 911 5393161
SGTC_2384 9036245 200 µM 0.878982853824905 0.209343505988036 no 712 0.189705286321009 960 6462766
SGTC_357 1325-0123 420 µM 0.87867875148012 0.209421746676578 no 713 0.189787741427485 936 1098503
SGTC_2125 5246583 200 µM 0.874812776937181 0.210417899144217 no 714 0.19083789199458 1010 835267
SGTC_2460 5552655 174.22 µM 0.87273528032792 0.210954358377573 no 715 0.191403691504282 917 5401989
SGTC_3300 9124615 50.48 µM 0.872724734162525 0.210957083693348 no 716 0.191406566338353 934 24824903
SGTC_2165 5727197 32.143 µM 0.87235826059258 0.211051799770353 no 717 0.191506481709296 888 1361712
SGTC_552 k242-0005 476 µM 0.868980113964866 0.211926064060812 no 718 0.192429003906845 926 4088318
SGTC_1051 3253-3903 78 µM 0.868609049724847 0.212022224438258 no 719 0.192530501456207 1000 5509239
SGTC_1057 3448-5381 134 µM 0.867813568002603 0.212228457519807 no 720 0.19274820056902 971 5497911
SGTC_2151 5563267 85.4165 µM 0.866762254340626 0.212501196272646 no 721 0.19303614371843 963 5310824
SGTC_1448 4255-0083 152 µM 0.862243802799311 0.213675731611098 no 722 0.194276685077793 1012 5399660
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.861766629326206 0.213799989430628 no 723 0.194407975924773 1023 16486 A toxic proline analog.
SGTC_1194 1488-0194 225 µM 0.859977574881551 0.214266240629946 no 724 0.194900702083247 966 1391452
SGTC_1902 st060212 70.5 µM 0.858223253688411 0.214724013740694 no 725 0.195384599022607 1011 688944
SGTC_2840 9008771 71.43 µM 0.856110766398888 0.215276000309971 no 726 0.19596825697795 931 2992978
SGTC_2717 st081029 62.2815 µM 0.852548934076399 0.216208558699922 no 727 0.196954745772167 952 5292846
SGTC_2270 7924575 90.91 µM 0.849199421618897 0.217087657860599 no 728 0.197885167527456 992 1262135
SGTC_1002 4049-0206 172 µM 0.847702963960212 0.217481078455099 no 729 0.198301707637965 1015 4662749
SGTC_2982 9019404 25.97 µM 0.847030582151035 0.217657982398667 no 730 0.19848903779112 912 22333232
SGTC_569 4130-2812 160 µM 0.846754526957178 0.217730636674822 no 731 0.198565979552494 875 743552
SGTC_154 3389-1638 511.116 µM 0.846235229792219 0.217867347105332 no 732 0.198710766157026 870 5238686
SGTC_1783 st039459 87.517 µM 0.844750453105081 0.218258503169745 no 733 0.199125091711816 1035 729761
SGTC_1531 st059297 52.4 µM 0.843077146118899 0.218699811063298 no 734 0.199592649691249 987 7566702
SGTC_1746 st038117 42 µM 0.84122402261216 0.219189141476122 no 735 0.200111222530331 940 2898218
SGTC_2468 5987765 72.9 µM 0.840839996651938 0.219290624930742 no 736 0.200218788485881 1031 26772094
SGTC_1698 5-fluorocytosine 1.055 µM 0.83933072495137 0.219689729561092 no 737 0.200641873115096 1009 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3307 9126885 69.2785 µM 0.836140838192279 0.220534618868732 no 738 0.201537838175326 973 24824909
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.83426457172237 0.221032444545305 no 739 0.20206595567925 1035 3256 An antibiotic and ribosome inhibitor.
SGTC_3075 9116269 49.47 µM 0.834151602548128 0.221062438922246 no 740 0.20209777981181 988 17015205 YNL244C SUI1
SGTC_214 4373-3496 70 µM 0.833914374998114 0.221125432645897 no 741 0.202164618077757 1120 3779166
SGTC_2999 9069765 71.4286 µM 0.833760908016568 0.221166189946002 no 742 0.202207864058586 1027 2097066
SGTC_653 0203-0016 55.2 µM 0.831967090965668 0.221642905098213 no 743 0.202713760134185 1013 295302
SGTC_1273 0849-0096 14.1 µM 0.831827581627534 0.221680004941047 no 744 0.20275313652491 973 5286025
SGTC_1353 1498-1206 8.11 µM 0.831627823440955 0.221733132991271 no 745 0.202809526057485 1025 6756808
SGTC_1904 st060225 78 µM 0.828606545442629 0.222537564131855 no 746 0.203663541501286 971 66595
SGTC_903 1134-0042 114 µM 0.828517666128145 0.222561253885545 no 747 0.203688697171264 973 701009
SGTC_2809 7964133 12.99 µM 0.826016344828898 0.223228541536235 no 748 0.204397410013349 978 1253665
SGTC_2019 4016004 108 µM 0.825805885022011 0.223284738648216 no 749 0.204457107598811 969 45595336
SGTC_2624 nerol 100 µM 0.825735476887013 0.223303540870659 no 750 0.204477081403878 979 637566 A natural product oil.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.824645978793687 0.223594601985447 no 751 0.204786304801922 1031 4213774
SGTC_378 3970-0959 8.33 µM 0.824064683961799 0.223749984030845 no 752 0.204951402711642 999 6615653
SGTC_2193 5925765 200 µM 0.823822462228487 0.223814748821372 no 753 0.205020221274683 997 877370
SGTC_2284 7945075 39.21 µM 0.823496502786001 0.223901920057871 no 754 0.205112852561751 1081 1245402
SGTC_499 genistein 192 µM 0.816695308172779 0.225725157072369 no 755 0.207051286626048 1027 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2109 5483026 200 µM 0.816579388908844 0.225756304865526 no 756 0.207084418876281 1019 759335
SGTC_1861 st057647 17.4 µM 0.814750321684601 0.226248101478178 no 757 0.20760762120153 1027 688668
SGTC_1275 0867-0008 21.1 µM 0.810864003990768 0.22729505493355 no 758 0.208721886889681 1028 3422836
SGTC_3321 9137793 26.8275 µM 0.810242426879936 0.227462757387125 no 759 0.208900428766751 1045 4904192
SGTC_605 1315-0399 119 µM 0.808745320500726 0.22786696491661 no 760 0.209330826917531 1054 24020461
SGTC_253 dyclonine 31.25 µM 0.808252350989142 0.228000151398495 no 761 0.209472663222267 1080 3180 An oral anasthetic.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.807164583322689 0.228294190447049 no 762 0.209785833740364 1070 6728940
SGTC_3011 9081274 71.4286 µM 0.806211251263275 0.22855206480169 no 763 0.210060526170116 1032 6625322
SGTC_1261 0712-0010 12.7 µM 0.80479365508941 0.228935824004063 no 764 0.210469381843591 1061 2840123
SGTC_777 1315-0167 517 µM 0.803956491190254 0.229162623386164 no 765 0.210711051489994 949 4221767
SGTC_1750 st081859 2.357 µM 0.803329975387238 0.229332437665751 no 766 0.210892018407093 1110 5291695
SGTC_865 0488-0499 301 µM 0.799861711720171 0.230273769945991 no 767 0.211895461745847 1087 9634651
SGTC_2015 5119600 184 µM 0.799727958650963 0.230310115506662 no 768 0.211934215239487 1042 2828786
SGTC_1662 st014054 52 µM 0.797923104588685 0.230800873411483 no 769 0.212457557317058 1061 2838777
SGTC_208 k072-0098 12.366 µM 0.795622294755828 0.231427332618329 no 770 0.213125802041211 1104 5948901
SGTC_224 benfluorex 43.875 µM 0.794731042095121 0.231670255380195 no 771 0.21338498557741 1045 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1657 st012939 43.4 µM 0.793827123637404 0.231916775445186 no 772 0.213648040009839 1021 24207257
SGTC_2831 7999036 19.48 µM 0.792625445012029 0.232244727872921 no 773 0.213998039671634 1058 2988270
SGTC_133 0724-0033 378.92 µM 0.79251773521922 0.232274135756248 no 774 0.214029427403468 983 280309
SGTC_429 1112-0049 25.5 µM 0.790630839945896 0.23278964858667 no 775 0.214579722420936 965 2836170
SGTC_306 1672-3436 11.6 µM 0.790438225141406 0.232842308020366 no 776 0.214635942917928 1081 6797378
SGTC_482 fipronil 114 µM 0.790194919738162 0.232908835340114 no 777 0.214706971245775 1054 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.789849248098489 0.233003370950327 no 778 0.214807906909853 1088 4174840
SGTC_885 0865-0106 16.8 µM 0.788617613592514 0.233340376261922 no 779 0.215167766587672 1076 2793380
SGTC_1191 1487-1166 10.6 µM 0.786109783491961 0.234027415172697 no 780 0.215901586558198 1133 3955771
SGTC_2740 felodipine 17.08 µM 0.785262531666332 0.234259779143312 no 781 0.21614982954488 1010 3333 L-type calcium channel blocker
SGTC_2396 5342950 42.78 µM 0.784428473945459 0.234488649240311 no 782 0.216394368062716 1065 1886677
SGTC_952 1185-0122 232 µM 0.7840089385626 0.234603818837492 no 783 0.216517432714559 1078 678600
SGTC_2033 5192550 145 µM 0.783802371328983 0.234660536547893 no 784 0.216578041107091 1062 182073
SGTC_2403 6032726 181.2 µM 0.782698179413657 0.234963845995472 no 785 0.216902185799723 1042 2881040
SGTC_711 k292-0785 179 µM 0.782045654940496 0.235143189115905 no 786 0.217093871527561 1111 4146315
SGTC_3145 9085516 49.47 µM 0.780670746507423 0.235521323246298 no 787 0.217498085159833 1052 25236195
SGTC_1031 k035-0009 16 µM 0.779714383705325 0.235784544607473 no 788 0.217779505260683 1128 5180959
SGTC_98 0074-0023 107.663 µM 0.779532681255794 0.235834573211506 no 789 0.217832996906917 1088 3563821
SGTC_55 0767-0285 6.563 µM 0.779031252121613 0.235972663341027 no 790 0.21798065265835 1074 3116166
SGTC_2113 5491891 107.031 µM 0.777473073895675 0.236402059135756 no 791 0.218439857241752 1125 789979
SGTC_1439 4092-1168 46 µM 0.777388607665405 0.236425348245904 no 792 0.218464765861628 1075 2886240
SGTC_2294 7971431 200 µM 0.774773774184205 0.237146936993041 no 793 0.219236674379004 997 5741572
SGTC_2329 6138490 200 µM 0.773905703011628 0.237386756929538 no 794 0.219493278406119 947 720019
SGTC_104 0074-0074 590.992 µM 0.773868146174093 0.237397135671098 no 795 0.219504384194341 949 3943124
SGTC_2790 5423970 71.43 µM 0.773023339235777 0.237630661852851 no 796 0.219754284090493 1099 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1955 wogonin 32.4 µM 0.772024531617655 0.237906920281073 no 797 0.220049949079741 1059 5281703 A flavanone.
SGTC_2703 st077852 53.4 µM 0.771828090918179 0.237961274181239 no 798 0.220108125897382 1037 6281836
SGTC_3223 9129970 49.47 µM 0.770859594892442 0.238229350408388 no 799 0.220395079393525 1108 17248386
SGTC_324 1315-0088 19.6 µM 0.769821457535703 0.238516886732934 no 800 0.220702904741038 1019 6787421
SGTC_511 blebbistatin 171 µM 0.769760222734115 0.23853385306929 no 801 0.220721069586883 1082 3476986 A myosin inhibitor.
SGTC_2863 9028737 58.44 µM 0.767914042031938 0.239045684739872 no 802 0.221269127213477 1074 6460917
SGTC_2406 ethylparaben 405.7 µM 0.766475047693176 0.239445044812081 no 803 0.221696846654579 993 8434 A possible steroid mimic.
SGTC_1119 parthenolide 318.541 nM 0.7664264620627 0.239458535001583 no 804 0.22171129624262 1135 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1432 4049-0298 68.4 µM 0.763780242829603 0.240193905486106 no 805 0.222499106264367 1096 741646
SGTC_392 N-ethylmaleimide 8.33 µM 0.762703712980622 0.240493419322954 no 806 0.222820057864206 1059 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2791 5663188 71.43 µM 0.759534052034289 0.241376467206501 no 807 0.223766576082177 1062 54690634
SGTC_289 k017-0060 526 µM 0.758848371334098 0.241567725082713 no 808 0.223971633059421 1109 5512909
SGTC_2955 9076254 12.21 µM 0.758693536202652 0.24161092484858 no 809 0.224017952218059 1058 16459619
SGTC_825 1988-2224 89.6 µM 0.757438893042059 0.241961131131212 no 810 0.224393481227216 1070 1180859
SGTC_918 glabranin 770.725 nM 0.757069056846091 0.242064415361402 no 811 0.224504245565637 1092 124049 Also referred to as licorice root.
SGTC_1693 xanthone 101.9 µM 0.755371886726599 0.2425386908537 no 812 0.225012938326895 1114 7020 An insecticide.
SGTC_2970 9090938 41.86 µM 0.754018394182584 0.242917285806122 no 813 0.225419088370474 1135 17217104
SGTC_2467 5474540 200 µM 0.752510417051758 0.24333946901276 no 814 0.225872083863671 1117 5413519
SGTC_2243 6634756 200 µM 0.750064571324123 0.244025066383012 no 815 0.226607908004979 1093 885676
SGTC_3283 9109332 35.8195 µM 0.749214247447577 0.24426366535213 no 816 0.226864041593796 994 17027281
SGTC_770 0389-1121 67.2 µM 0.748946566388728 0.244338802073612 no 817 0.226944705960919 1155 6753108
SGTC_2589 lobaric acid 100 µM 0.748077336958366 0.244582876262339 no 818 0.227206755479731 1126 73157 A novel microtubule depolymerizer.
SGTC_3257 9139206 32.98 µM 0.74784417367029 0.244648369385177 no 819 0.227277076997392 1088 4910041
SGTC_1182 1222-0449 220 µM 0.747800021479401 0.244660772336051 no 820 0.227290394578785 1079 658318
SGTC_1481 3346-2004 36 µM 0.745851988974589 0.245208338042113 no 821 0.227878415205151 1155 2770522
SGTC_3194 9111903 49.47 µM 0.744759580241913 0.245515687546319 no 822 0.228208536937388 1117 17087251
SGTC_1687 st020778 55.3625 µM 0.744356454457909 0.245629159356486 no 823 0.228330427885315 1160 4259299
SGTC_2754 granisetron 64.02 µM 0.744303711665993 0.245644007476252 no 824 0.2283463781424 1111 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2344 7990960 76.95 µM 0.743850226829368 0.24577169214814 no 825 0.22848354498685 1075 140813
SGTC_626 0214-0009 33 µM 0.743150875691209 0.245968673564083 no 826 0.228695170418998 1128 3437874
SGTC_1443 4112-3303 14 µM 0.742914022355827 0.246035405609152 no 827 0.228766867781885 1143 704433
SGTC_2531 methyl deoxycholate 70.07 µM 0.74260330161186 0.246122964092042 no 828 0.228860944521628 1100 16667744 Haematoxylin.
SGTC_2742 clothiapine 36.27 µM 0.74253024074757 0.246143554453476 no 829 0.228883068269878 1072 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1946 st076057 65.1 µM 0.742164933005895 0.246246521080897 no 830 0.22899370604972 1030 953009
SGTC_34 0469-0683 81.75 µM 0.741957192474446 0.246305085687649 no 831 0.229056636113536 1115 3690923
SGTC_1665 st014639 11.4 µM 0.741553833885929 0.246418818746977 no 832 0.229178851726861 1195 981133 YIL048W NEO1
SGTC_2137 5261020 140 µM 0.738897491751757 0.24716851708284 no 833 0.229984622769393 1130 763655
SGTC_2834 9001755 58.44 µM 0.73879923035781 0.247196272732049 no 834 0.230014459620064 1025 2989575
SGTC_2281 7943571 200 µM 0.73860072700338 0.247252348560373 no 835 0.230074741323717 1192 1244024
SGTC_883 0850-0245 24.6 µM 0.736657594352955 0.247801629108311 no 836 0.230665300428682 1137 6823229 YPR165W RHO1
SGTC_1817 st052116 64.4 µM 0.736435816518479 0.247864362182465 no 837 0.230732757207325 1123 4361398
SGTC_2336 9001819 198.65 µM 0.734246272153611 0.248484161255555 no 838 0.231399328365521 1170 2989602
SGTC_901 1112-0062 60.1 µM 0.732169642711967 0.24907275946669 no 839 0.232032515384333 1163 1908457
SGTC_2114 5491910 81.25 µM 0.730476014557014 0.249553348691107 no 840 0.232549634484272 1152 2849228
SGTC_3083 9117465 49.47 µM 0.730356390334157 0.24958731225309 no 841 0.232586183816114 1150 16420915
SGTC_679 0422-0091 41.4 µM 0.730031978707532 0.2496794311606 no 842 0.232685318845418 1188 627384 YHR062C RPP1
SGTC_2664 lyso-paf C-16 73.48 µM 0.729469566737411 0.249839174677303 no 843 0.232857238628357 1160 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2770 toltrazuril 17.5 µM 0.727705195179232 0.250340666177703 no 844 0.233397034724422 1141 68591 Kills coccidiodes.
SGTC_3304 9125678 46.087 µM 0.727678493198623 0.250348259841809 no 845 0.23340520932208 1108 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2489 cantharidin 73.42 µM 0.726655822267974 0.250639184803618 no 846 0.233718411354061 1167 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_927 2425-1185 123 µM 0.722966594468189 0.251690166657978 no 847 0.234850203924735 1161 730375
SGTC_2622 2-methoxyxanthone 59.94 µM 0.722460154363246 0.251834622042991 no 848 0.235005807286204 1171 71034 A hepatoprotective.
SGTC_2127 5253358 187.912 µM 0.720712886250207 0.252333343114517 no 849 0.235543091180258 1113 20612
SGTC_2588 indole-3-carbinol 100 µM 0.720032287740887 0.25252774650611 no 850 0.235752558073059 1149 3712 Induces cell cycle arrest.
SGTC_282 k297-0036 65.7 µM 0.719856127124529 0.252578077161309 no 851 0.23580679151928 1140 5061378
SGTC_2898 9056270 58.44 µM 0.719423083374017 0.252701824071951 no 852 0.235940139171677 1095 19154699
SGTC_518 1021-0119 62.6 µM 0.719312684606056 0.252733376814232 no 853 0.235974141036277 1098 1097762
SGTC_697 0508-1955 564 µM 0.719064001497506 0.252804459790262 no 854 0.236050743172063 1159 6243113
SGTC_1242 0402-0103 60.1 µM 0.717283154292446 0.25331380024262 no 855 0.236599699695872 1142 432868
SGTC_1944 st076371 56.9 µM 0.715652235530357 0.253780732467583 no 856 0.237103055471084 1143 24208455
SGTC_1152 3909-8331 15.9 µM 0.714197735079193 0.254197536996205 no 857 0.237552458610048 1154 16001939
SGTC_852 0418-0143 439 µM 0.713962937000051 0.254264854834503 no 858 0.237625048961261 1206 5369229
SGTC_2980 9014342 25.29 µM 0.7137193547929 0.254334701004907 no 859 0.2377003678814 1166 2996599
SGTC_1846 st056244 14.8 µM 0.713129733104461 0.254503814165947 no 860 0.237882741110199 1164 5393182
SGTC_1263 0774-1208 64.8 µM 0.712975429449043 0.254548080707073 no 861 0.237930480742745 1206 906585
SGTC_522 1273-0010 11.6 µM 0.712464718446096 0.254694621939383 no 862 0.238088525835232 1227 5705015
SGTC_1397 3532-0190 20.1 µM 0.71170368066588 0.254913072803037 no 863 0.238324143989291 1097 5322280
SGTC_3053 9095903 49.47 µM 0.711363417526864 0.255010774798524 no 864 0.238429531140668 1221 17174018
SGTC_3190 9110366 49.47 µM 0.709535020267747 0.255536109834514 no 865 0.238996263633748 1098 17123768
SGTC_23 0213-0011 39.996 µM 0.708795238645636 0.255748824397602 no 866 0.239225776456944 1180 627608
SGTC_3285 9112818 20.8695 µM 0.70843287322405 0.255853051572083 no 867 0.239338242088591 1224 17017947 YPR165W RHO1
SGTC_2079 5212404 121 µM 0.706085473896449 0.256528770680689 no 868 0.240067492306803 1180 758462
SGTC_190 3970-0790 3.722 µM 0.705472741229362 0.256705303926973 no 869 0.240258044877761 1158 2832352
SGTC_814 3342-0569 96 µM 0.704624928072937 0.256949670030118 no 870 0.240521840540645 1208 4346283
SGTC_3045 9092950 49.47 µM 0.704212492891469 0.257068590412159 no 871 0.240650226066893 1202 44120432
SGTC_760 0568-0725 82.9 µM 0.701464206485774 0.25786175375002 no 872 0.241506682376333 1197 3916171
SGTC_2349 9023730 187.07 µM 0.701222998741002 0.257931427565046 no 873 0.241581929570399 1170 4126287
SGTC_1146 3579-1023 7 µM 0.698721056163174 0.258654699254621 no 874 0.242363186174616 1223 X1146
SGTC_2167 5876490 200 µM 0.698063230585181 0.258845040315142 no 875 0.242568825848586 1207 686534
SGTC_31 0508-1974 57.237 µM 0.697163657234505 0.259105448082863 no 876 0.24285019001243 1165 6810525
SGTC_44 0929-0055 61.211 µM 0.697116962563775 0.259118968915506 no 877 0.242864799763714 1160 1379590
SGTC_2545 solidagenone 89.61 µM 0.696696149167588 0.259240835410418 no 878 0.242996484615978 1028 6708572 An anti ulcer agent
SGTC_250 brefeldin a 552.239 µM 0.693652588559394 0.26012312392824 no 879 0.243950052796015 1100 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_848 0368-0089 85.6 µM 0.68925577874986 0.261400429503265 no 880 0.245331160466569 1189 762535
SGTC_1916 st067606 49.2 µM 0.688482769254349 0.261625326920353 no 881 0.245574408673045 1228 19590279
SGTC_1972 st070201 17.4 µM 0.688037201160836 0.261755004470429 no 882 0.245714677481416 1194 2829099
SGTC_2199 6590217 200 µM 0.68665786078591 0.262156654816169 no 883 0.246149178715743 1157 703109
SGTC_1141 3253-0389 52.6 µM 0.686273022340795 0.262268772305821 no 884 0.246270478821213 1191 5402031
SGTC_2714 st079313 56.9 µM 0.686178396999446 0.262296343884287 no 885 0.246300309397681 1205 2939799
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.685895662474406 0.262378734858321 no 886 0.246389452809824 1180 689007
SGTC_1132 3456-3614 2.5 µM 0.685682152214839 0.262440962140669 no 887 0.246456781950443 1263 3125502
SGTC_395 anisomycin 6.25 µM 0.682520299813645 0.263363363479319 no 888 0.247455005590269 1178 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_138 0850-0259 40.9225 µM 0.681777171017363 0.263580395056887 no 889 0.24768993084107 1256 6813004
SGTC_2191 5911152 200 µM 0.676683935404505 0.265070332216843 no 890 0.24930325560641 1222 2875902
SGTC_2709 st078560 56 µM 0.676162123432717 0.265223220460299 no 891 0.249468858831835 1244 17250903
SGTC_284 0988-0104 32.6 µM 0.674630193329493 0.265672326690093 no 892 0.249955372576309 1244 4666532
SGTC_2172 5754775 163.918 µM 0.674492929324572 0.265712586323165 no 893 0.249998989748527 1166 2263357
SGTC_595 3909-8003 73.7 µM 0.673561751638971 0.265985783060935 no 894 0.250294988469375 1267 699517
SGTC_149 3970-0822 46.1 µM 0.673533373383439 0.265994111145918 no 895 0.25030401214284 1282 3114250 YBL034C STU1
SGTC_1654 st012436 41.8 µM 0.673071538424455 0.266129663086627 no 896 0.250450889944375 1202 4323132
SGTC_2764 methyldopa 94.69 µM 0.673026954759472 0.266142750569702 no 897 0.250465071345959 1249 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_799 1310-0557 151 µM 0.672313214591873 0.266352312525946 no 898 0.250692159416672 1251 5354492
SGTC_3148 9097893 49.47 µM 0.671879250615225 0.266479769923758 no 899 0.250830285417367 1169 17174100
SGTC_862 0452-0056 10.2 µM 0.670827629861821 0.26678876412933 no 900 0.251165171877151 1193 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_142 0335-0849 62.6745 µM 0.669832337973656 0.267081374095984 no 901 0.251482338211239 1266 3889043 YPR107C YTH1
SGTC_3061 glucosamine 200 µM 0.669722923548545 0.267113551177016 no 902 0.251517217847374 1188 91431 and experimental redox chemotherapeutic
SGTC_3207 9114163 49.47 µM 0.667509283873875 0.267764968240497 no 903 0.25222344078144 1291 849233
SGTC_1793 st048256 72.231 µM 0.665805806919027 0.268266801985558 no 904 0.252767616369582 1174 672022
SGTC_1164 k060-0068 93.7 µM 0.663993311637764 0.268801270901993 no 905 0.253347295925896 1274 5963676
SGTC_661 1304-0007 33.6 µM 0.663924001088474 0.268821719820486 no 906 0.253369476969647 1247 3117130
SGTC_686 1319-0111 510 µM 0.663153160670108 0.269049196045102 no 907 0.253616233242737 1299 4562600
SGTC_72 0744-0168 198.391 µM 0.663019870770531 0.269088539899313 no 908 0.253658913909766 1185 677577
SGTC_882 0843-0131 351 µM 0.661641922114331 0.2694954451061 no 909 0.254100366886066 1269 5425421
SGTC_755 1995-0008 37.3 µM 0.658353546429483 0.270467739660788 no 910 0.255155488926026 1247 689533
SGTC_2122 5258151 111.688 µM 0.657230532111337 0.270800189378743 no 911 0.255516348163387 1235 2173356
SGTC_2819 7996655 46.38 µM 0.655971979559554 0.271173005173785 no 912 0.255921076632591 1161 6456960
SGTC_3215 9129942 49.47 µM 0.655558624662163 0.271295507382544 no 913 0.256054077272119 1200 17682944
SGTC_1104 tacrolimus 29.8 µM 0.652584324372087 0.272177785991579 no 914 0.257012147040749 1303 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2377 9073351 62.6 µM 0.651467138341005 0.272509549413129 no 915 0.257372491710794 1228 7337946 YHR072W ERG7
SGTC_1126 isoteolin 1.0172 µM 0.650425625127887 0.272819021519247 no 916 0.257708664671676 1245 133323
SGTC_1262 0737-0114 49.6 µM 0.650062217107953 0.272927044498606 no 917 0.257826016806025 1300 765919
SGTC_3253 9135987 49.47 µM 0.650048428464021 0.272931143588549 no 918 0.257830469996747 1259 4182430
SGTC_3015 9080845 49.47 µM 0.649522598923714 0.273087485042204 no 919 0.25800032207759 1309 5296973
SGTC_1865 st057639 52.2 µM 0.648631924218605 0.273352404746174 no 920 0.258288157847198 1269 688818
SGTC_341 1486-1430 230 µM 0.645677123768825 0.274232182444881 no 921 0.259244239350845 1235 2054753 YPL210C SRP72
SGTC_1163 k060-0048 49.9 µM 0.64560828719512 0.274252694861436 no 922 0.259266534506359 1276 6809982
SGTC_188 3229-0966 278.469 µM 0.645346822247727 0.274330614967963 no 923 0.259351228192784 1377 5722370
SGTC_38 0929-0051 58.268 µM 0.644567914997468 0.274562804668269 no 924 0.259603616404442 1277 1379719
SGTC_2641 levomentholum 100 µM 0.64302190028418 0.275023953590044 no 925 0.260104944723061 1234 16666
SGTC_2423 st077119 87.2 µM 0.643001677602389 0.275029988186493 no 926 0.260111505665268 1237 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2997 9067075 71.4286 µM 0.641687460655255 0.275422299951863 no 927 0.260538066264401 1281 27209819
SGTC_2195 6536160 144.242 µM 0.640730495106149 0.275708140405329 no 928 0.260848898819651 1183 3834386
SGTC_2785 7756463 72.73 µM 0.640250959702873 0.275851429868449 no 929 0.261004728715412 1266 2201551
SGTC_1581 himbacine 57.9 µM 0.636079561363797 0.277099422167588 no 930 0.262362283188976 1278 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2583 asiatic acid 100 µM 0.635917918971981 0.277147837633284 no 931 0.262414961336137 1304 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2062 5245942 200 µM 0.634747841503283 0.277498425040945 no 932 0.262796442981034 1345 1376160
SGTC_2572 astragaloside iv 100 µM 0.634113916232264 0.277688456980316 no 933 0.263003240731592 1319 45006101 An anti-inflammatory agent.
SGTC_3246 9135460 32.98 µM 0.633341509595254 0.277920087387868 no 934 0.263255325947343 1244 41446951
SGTC_1046 2001-0062 216 µM 0.630959870689762 0.278634889770627 no 935 0.264033381730876 1260 739778
SGTC_3332 9141069 11.198 µM 0.628441030728293 0.27939184312753 no 936 0.264857532693519 1255 17332883
SGTC_2645 abamectin 100 µM 0.627923980904998 0.279547348690897 no 937 0.265026870245118 1271 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1996 st072960 66.8 µM 0.62726994556187 0.279744113576125 no 938 0.2652411503099 1289 1719405
SGTC_1465 k213-0056 144 µM 0.627051023879598 0.279809990620641 no 939 0.265312894751271 1250 24048857 YMR208W ERG12
SGTC_2532 xanthone 78.9 µM 0.626715556640941 0.279910952690984 no 940 0.265422852307237 1265 7020 An insecticide.
SGTC_1014 4130-3005 69.3 µM 0.626262524179109 0.280047325169883 no 941 0.26557138142011 1290 743608
SGTC_2707 st078556 66.6 µM 0.625833772601601 0.280176418237762 no 942 0.265711988734102 1292 17250899
SGTC_2288 7946289 167.31 µM 0.625016437295061 0.280422590054911 no 943 0.265980134997741 1358 1246052
SGTC_714 4296-0578 26.1 µM 0.624648474529737 0.280533450301055 no 944 0.266100898658201 1297 1589775
SGTC_548 1436-0017 110 µM 0.623933820117792 0.280748822787787 no 945 0.266335524204056 1365 9677137
SGTC_796 1234-0020 70.7 µM 0.620719601668829 0.281718466063114 no 946 0.267392064996702 1258 46495034
SGTC_2845 9003024 42.97 µM 0.620220374219072 0.281869214288263 no 947 0.267556354766952 1392 2990173
SGTC_822 1487-0950 154 µM 0.619329780870197 0.282138237017638 no 948 0.267849564685424 1325 1958375
SGTC_2611 pyromycin 23.93 µM 0.618211370946708 0.282476251588734 no 949 0.268218007739834 1298 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3069 9117009 49.47 µM 0.618200379167416 0.282479574576123 no 950 0.268221630078549 1214 41904981
SGTC_1386 3228-0095 33.8 µM 0.613570036575798 0.283881068973157 no 951 0.26974974435608 1354 870181
SGTC_2277 7947813 106.88 µM 0.613251622656166 0.283977567455247 no 952 0.269854987908568 1392 1246798
SGTC_2010 4012422 159 µM 0.610838514296907 0.284709393509671 no 953 0.270653246586871 1333 952393
SGTC_3278 9139605 49.47 µM 0.610748101482847 0.284736830591349 no 954 0.270683178140818 1355 7958859
SGTC_2639 lactacystin 53 µM 0.60826941108031 0.285489516299941 no 955 0.271504402608801 1357 3870 A proteasome inhibitor.
SGTC_995 3931-2021 34.6 µM 0.607846461168026 0.285618044938252 no 956 0.271644655617506 1343 730143
SGTC_1717 st033143 58.0435 µM 0.606577852306825 0.286003722726671 no 957 0.272065551004989 1388 674616
SGTC_3195 9113082 49.47 µM 0.605815027976124 0.286235752864989 no 958 0.272318794677894 1311 17018038
SGTC_3259 9138485 49.47 µM 0.605801530218828 0.286239859315518 no 959 0.272323276739752 1435 17646153
SGTC_3317 9138495 8.753 µM 0.605317662342297 0.28638708591126 no 960 0.2724839739858 1320 17020139
SGTC_3270 9137563 49.47 µM 0.604337782373527 0.286685344270919 no 961 0.272809545856395 1343 17015724
SGTC_3164 9100705 49.47 µM 0.598682155998233 0.288409690096551 no 962 0.274692429327451 1378 17174235
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.598348634376485 0.288511530089879 no 963 0.27480366585586 1362 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3004 9076122 71.4286 µM 0.597235604364011 0.288851513600351 no 964 0.275175045575007 1352 44782551
SGTC_2628 lathosterol 100 µM 0.595538716799365 0.289370203447017 no 965 0.275741713563786 1381 6710616
SGTC_2657 nystatin 74.44 µM 0.595502265739825 0.289381350289801 no 966 0.27575389252126 1351 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_477 mead ethanolamide 10 µM 0.594292795134745 0.289751324357212 no 967 0.27615814835038 1254 16061185
SGTC_1735 st034310 56.75 µM 0.593115507016575 0.290111666910334 no 968 0.276551926621602 1442 871153
SGTC_2024 5144227 134 µM 0.592264838420353 0.290372168887441 no 969 0.276836628687567 1360 3475211
SGTC_1710 st031758 61.5 µM 0.592199317532653 0.290392238024352 no 970 0.2768585631941 1409 5394341
SGTC_2812 7970281 58.44 µM 0.592169432998164 0.290401391913512 no 971 0.276868567958355 1433 2233435
SGTC_671 0560-0003 407 µM 0.5918260085131 0.290506595473179 no 972 0.276983552541608 1313 3238678
SGTC_2739 tacrine 100.86 µM 0.589302235139693 0.291280266773304 no 973 0.277829272878522 1359 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1418 3966-3099 2.4 µM 0.588118634397169 0.29164343457324 no 974 0.278226333111101 1387 740335
SGTC_81 0411-0046 9.971 µM 0.588054782511105 0.291663032440049 no 975 0.27824776124227 1258 12925265
SGTC_1546 5-methoxyflavanone 78.7 µM 0.587833784781576 0.291730867345352 no 976 0.278321932347205 1408 147795
SGTC_2369 9071472 200 µM 0.586440289566687 0.292158767756011 no 977 0.278789838092459 1408 17296037
SGTC_2936 9038235 15.59 µM 0.585885418502533 0.292329233209311 no 978 0.278976258388854 1350 4749415
SGTC_1849 st056239 19.2 µM 0.585526010458537 0.292439673908156 no 979 0.279097041229419 1260 5393181
SGTC_427 1354-0053 47.3 µM 0.582408578926483 0.293398426574535 no 980 0.280145752170917 1438 6813657
SGTC_1587 estradiol valerate 56.1 µM 0.581875131699877 0.293562631785523 no 981 0.280325396156729 1364 13791 A steroid.
SGTC_2713 st079149 53.4 µM 0.58037536174104 0.294024517374358 no 982 0.280830758226941 1385 3103253
SGTC_1421 4029-0249 71.4 µM 0.57868781780091 0.294544633211036 no 983 0.281399918697946 1457 2894095
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.578174293538218 0.294702990102751 no 984 0.281573226201578 1338 688662
SGTC_1096 rimcazole 32.2 µM 0.575722190694904 0.295459692621394 no 985 0.282401486853137 1327 18528119 A dopamine reuptake inhibitor.
SGTC_3233 9132340 49.47 µM 0.575442194384449 0.295546154425706 no 986 0.28249613728691 1331 17682950
SGTC_3071 9117417 49.47 µM 0.573634790622328 0.296104553605227 no 987 0.28310748191825 1344 45595590 YGL055W OLE1
SGTC_1984 st072354 53.1 µM 0.573141245093633 0.296257119094432 no 988 0.283274531332409 1336 5762938
SGTC_991 3996-0057 64.7 µM 0.570691109548875 0.297015041627356 no 989 0.284104523171181 1390 715343
SGTC_3085 9117376 49.47 µM 0.570299097519877 0.29713638849995 no 990 0.284237426452618 1438 16480349
SGTC_3124 9127567 49.47 µM 0.569937674677986 0.297248286602885 no 991 0.284359985453771 1416 17592030
SGTC_2215 7188065 200 µM 0.569503030228832 0.297382879937554 no 992 0.284507407444592 1412 940217
SGTC_101 0490-5701 117.494 µM 0.56796901716207 0.297858129487991 no 993 0.285028003058849 1321 4661669
SGTC_3221 9128209 49.47 µM 0.56746369235639 0.298014758966014 no 994 0.285199593748925 1409 16460723
SGTC_1512 0259-0544 12.2 µM 0.567340312358921 0.298053007286842 no 995 0.285241496771137 1374 18476
SGTC_1493 4348-0038 111 µM 0.567002519744632 0.298157735869361 no 996 0.285356234843152 1427 800424
SGTC_1388 3346-4487 254 µM 0.563309381437079 0.299303841253291 no 997 0.28661211549637 1438 3345614
SGTC_2453 5731132 22.18 µM 0.562876200546233 0.299438402745142 no 998 0.286759593659516 1494 1362040
SGTC_1296 1068-0102 11.9 µM 0.56167622900129 0.299811300015183 no 999 0.287168316501291 1411 767053
SGTC_2658 polymyxin b sulfate 77.05 µM 0.561620737430425 0.299828549388918 no 1000 0.28718722417943 1371 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2608 thymoquinone 42.66 µM 0.559571380670576 0.300465899695083 no 1001 0.287885915206598 1314 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1574 spiramycin 23.7 µM 0.559340796178871 0.300537649797867 no 1002 0.287964579021266 1350 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2705 st078069 42.8 µM 0.556685083877119 0.301364574818583 no 1003 0.288871304947605 1366 1530061
SGTC_2727 riluzole 51.77 µM 0.556563871657316 0.301402341824716 no 1004 0.288912721845272 1409 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1142 3253-1408 9.78 µM 0.556265983372101 0.301495166176405 no 1005 0.289014518904184 1401 256655
SGTC_2882 9058044 58.44 µM 0.554492332462785 0.302048115973638 no 1006 0.28962097584729 1321 18076804
SGTC_2302 7771753 200 µM 0.554341419165807 0.30209518541219 no 1007 0.289672604557117 1344 2203047
SGTC_3277 9138724 49.47 µM 0.553971824505485 0.302210474868043 no 1008 0.289799064243742 1365 15943418
SGTC_1012 4112-3522 18 µM 0.553259411005863 0.302432757162751 no 1009 0.290042895113142 1423 3112398
SGTC_2077 5212015 200 µM 0.551261092684502 0.30305664939307 no 1010 0.290727352867148 1309 780900
SGTC_131 0141-0277 33.849 µM 0.551226597477173 0.303067424148627 no 1011 0.290739174687128 1468 1547771
SGTC_3180 9109287 49.47 µM 0.549505583321755 0.303605209187902 no 1012 0.291329266998919 1396 18891271
SGTC_2076 5212012 200 µM 0.548196988832436 0.304014405637847 no 1013 0.29177832474106 1363 604802
SGTC_2152 5568786 200 µM 0.547425454925548 0.304255778823482 no 1014 0.292043235630235 1395 5399883
SGTC_1338 1486-1223 76 µM 0.547107645383691 0.304355229859994 no 1015 0.292152390031335 1488 3444526
SGTC_1460 k062-0059 9.15 µM 0.546673223387126 0.30449119543444 no 1016 0.292301626679937 1377 1373085
SGTC_8 0354-0001 70 µM 0.546541931750181 0.304532292462869 no 1017 0.292346736169204 1449 4993152
SGTC_2814 7977482 42.97 µM 0.546381814103473 0.304582415975154 no 1018 0.292401754147709 1510 6456762
SGTC_1147 3809-1045 12.3 µM 0.543041060439054 0.305629047281254 no 1019 0.293550765977296 1374 325925
SGTC_1945 st075991 56.6 µM 0.542589239533275 0.30577072139877 no 1020 0.293706324683531 1351 1084980
SGTC_894 0960-0238 55.9 µM 0.541273310051543 0.306183513206519 no 1021 0.29415960701865 1418 6741907 YDL195W SEC31
SGTC_13 0199-0087 65 µM 0.540119544270865 0.30654563872814 no 1022 0.294557296529693 1443 4589825
SGTC_1367 1812-0510 76.9 µM 0.539866173396185 0.306625188037212 no 1023 0.294644663705063 1434 1142582 YDR527W RBA50
SGTC_418 lividomycin a 100 µM 0.539233034901518 0.306824010492916 no 1024 0.294863034334984 1404 72394 An antibiotic.
SGTC_930 2810-3379 265 µM 0.538110703694218 0.307176592230523 no 1025 0.295250311635154 1569 1015764
SGTC_277 nystatin 15.5 µM 0.53764337246142 0.307323457524683 no 1026 0.295411640333838 1401 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_368 fentichlor 4.58 µM 0.536798374094297 0.307589088376271 no 1027 0.295703447445428 1387 7329 A pesticide.
SGTC_2676 harmalol 100 µM 0.536429430924135 0.307705099772447 no 1028 0.295830897791268 1480 5459187 A monoamine oxidase inhibitor
SGTC_1773 st048542 73.5835 µM 0.53439794550773 0.308344229239667 no 1029 0.296533120057193 1350 3237138
SGTC_2108 5365811 200 µM 0.534317041514737 0.308369694647649 no 1030 0.296561101895872 1504 780283
SGTC_2358 9037157 4 µM 0.534170471742152 0.308415831419328 no 1031 0.296611798293171 1474 2388925
SGTC_3034 9090421 49.47 µM 0.533993910635852 0.308471412786485 no 1032 0.296672873536435 1408 17173761
SGTC_1699 st031318 29.054 µM 0.532032749980155 0.309089080338229 no 1033 0.297351656540718 1487 5340658
SGTC_2239 6685329 187.64 µM 0.531718682659968 0.309188046057805 no 1034 0.297460425167218 1428 805680
SGTC_3338 9144300 39.5675 µM 0.531182387900936 0.309357069849773 no 1035 0.297646198177934 1453 4901274
SGTC_3344 9148862 3.898 µM 0.530028429046929 0.309720899345979 no 1036 0.298046110036207 1507 4905352
SGTC_2240 6690706 185.951 µM 0.529236395148717 0.309970726168529 no 1037 0.29832073609708 1359 805876
SGTC_298 1391-0729 10 µM 0.527444723117922 0.310536186952887 no 1038 0.298942396554578 1423 3237558
SGTC_2459 5811157 9.22 µM 0.525948581359154 0.311008720213319 no 1039 0.299461966598135 1408 2870684 YBR192W RIM2
SGTC_1530 rhein 70.4 µM 0.52429159409003 0.311532417884144 no 1040 0.300037871280493 1465 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1886 st057356 49.9 µM 0.52330223751956 0.311845290095261 no 1041 0.300381972079806 1391 24207747
SGTC_1477 0139-0234 16 µM 0.522586116963069 0.312071839435879 no 1042 0.300631151866987 1483 620880
SGTC_1906 st060206 94.7 µM 0.522261428101138 0.312174580274826 no 1043 0.300744160649882 1458 5133468
SGTC_2625 euphol 100 µM 0.520488760516187 0.312735760422655 no 1044 0.301361479816561 1560 6708538 A triterpene alcohol.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.520022884716231 0.312883316631297 no 1045 0.301523812442156 1431 4620898
SGTC_2126 5251174 33.877 µM 0.517704404538315 0.313618091228898 no 1046 0.302332262347035 1598 790722
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.513332770822644 0.315005564593012 no 1047 0.303859282100412 1467 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_193 1273-0060 1.558 µM 0.511240101735726 0.31567066457766 no 1048 0.304591470780982 1396 2847393 YHR072W ERG7
SGTC_3095 9117207 49.47 µM 0.510585307467502 0.315878896577558 no 1049 0.304820733055029 1470 17015229
SGTC_1701 st028638 40.4 µM 0.50983853377753 0.316116450409539 no 1050 0.305082293532543 1538 3490878
SGTC_2428 5615643 7.78 µM 0.508561560372833 0.316522840308079 no 1051 0.305529789310045 1494 2253075
SGTC_2829 7992743 58.44 µM 0.507758392714377 0.316778557647049 no 1052 0.305811396075272 1540 16462845
SGTC_884 0851-0618 334 µM 0.505300964476224 0.317561511855257 no 1053 0.306673732753604 1512 9642473
SGTC_3179 9107801 49.47 µM 0.504960242290683 0.317670132930687 no 1054 0.30679338031584 1445 4818259
SGTC_1401 3807-4679 7.6 µM 0.504595954553028 0.317786283986182 no 1055 0.306921325898977 1488 3291456
SGTC_1621 st003705 32.4 µM 0.501685535480687 0.318714897579282 no 1056 0.30794437039381 1571 24207032
SGTC_3239 9133757 49.47 µM 0.499860304073678 0.31929784734206 no 1057 0.30858672253545 1537 17036923
SGTC_713 1488-1073 324 µM 0.499533990476352 0.319402113836364 no 1058 0.308701623630806 1483 3312542
SGTC_1745 st081495 74 µM 0.498878163653995 0.319611712387558 no 1059 0.308932609113585 1481 13842402 YBL026W LSM2
SGTC_175 3793-3120 23.7 µM 0.498071830362337 0.319869490942615 no 1060 0.309216707314247 1470 5322297
SGTC_762 1165-0429 115 µM 0.49604801747671 0.320516871423823 no 1061 0.309930266676863 1580 5967793
SGTC_900 1112-0045 141 µM 0.494383479955564 0.321049736003924 no 1062 0.310517689374886 1410 56211 YIL048W NEO1
SGTC_2224 6650123 117.647 µM 0.494273256984291 0.321085034459578 no 1063 0.310556604637322 1477 2908370
SGTC_850 0388-0143 75.9 µM 0.491620270584246 0.321935129655731 no 1064 0.311493905401173 1468 67273
SGTC_2258 7960471 200 µM 0.491290177210026 0.322040966656089 no 1065 0.311610613147058 1446 2974708
SGTC_2067 5224629 34.075 µM 0.491099082942779 0.322102243323295 no 1066 0.311678185048359 1467 2835000
SGTC_2606 farnesol 9.78 µM 0.489313383088842 0.32267508294629 no 1067 0.312309923826402 1572 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1032 k061-1018 98.7 µM 0.488545163227488 0.322921651965973 no 1068 0.312581871997578 1645 4005393
SGTC_2839 9003951 25.97 µM 0.488332080977443 0.322990056966554 no 1069 0.312657320743457 1519 2990634
SGTC_446 go6976 132 µM 0.486600615210395 0.323546124808903 no 1070 0.313270693749897 1562 3501 A protein kinase C inhibitor.
SGTC_2446 5162541 200 µM 0.486575479952532 0.323554200013655 no 1071 0.313279601743747 1450 1549321
SGTC_258 haloperidol 50.781 µM 0.485832706788636 0.323792868256786 no 1072 0.313542891441824 1437 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2121 5257820 149.641 µM 0.484722196913614 0.32414983300497 no 1073 0.31393670943668 1556 791256
SGTC_1097 itavastatin 7.23 µM 0.482498213771799 0.324865201059464 no 1074 0.314726033504429 1510 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.481787679390303 0.325093888430642 no 1075 0.314978391293162 1592 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1003 4049-0218 100 µM 0.479517839673109 0.32582488356473 no 1076 0.315785140028162 1575 295161
SGTC_1256 0570-0116 285 µM 0.479451819022385 0.325846155360981 no 1077 0.315808618318968 1476 410638
SGTC_1284 0929-0043 16 µM 0.478938843790498 0.326011454845938 no 1078 0.3159910680956 1499 1239883
SGTC_2260 7964312 200 µM 0.478836708933383 0.326044370536329 no 1079 0.316027399728223 1604 231951
SGTC_2851 9015922 71.43 µM 0.477892740828477 0.326348653644419 no 1080 0.316363274172223 1574 2996893
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.47548973826938 0.327123770130657 no 1081 0.317218972858901 1584 6710655
SGTC_780 0109-0199 192 µM 0.474898326264123 0.327314651526609 no 1082 0.317429722243811 1644 610414
SGTC_1727 st034309 9.9045 µM 0.472860991945276 0.327972557626175 no 1083 0.318156178226454 1643 870305
SGTC_2086 5274770 176.623 µM 0.472682656899194 0.328030171917504 no 1084 0.318219800837653 1522 689278
SGTC_1181 1222-0449 220 µM 0.47256041573861 0.328069666450816 no 1085 0.318263414555383 1586 658318
SGTC_746 1095-0025 46.6 µM 0.472068665095665 0.328228564122249 no 1086 0.318438888876039 1620 6749286
SGTC_1085 doxorubicin 7.67 µM 0.46754529705172 0.329691639155889 no 1087 0.320054895988762 1635 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_225 nsc-122657 1.016 µM 0.46750651704841 0.3297041937918 no 1088 0.320068765263806 1536 275685
SGTC_2296 7971656 126.45 µM 0.466271900695777 0.330103988650632 no 1089 0.320510444631158 1511 666570
SGTC_945 3381-0768 11.3 µM 0.463268356051081 0.331077409561555 no 1090 0.321586012395908 1549 1126236 YIL048W NEO1
SGTC_1162 k048-0130 20.1 µM 0.462180067451817 0.331430396209288 no 1091 0.3219760980063 1524 6797406
SGTC_738 1315-0003 72.4 µM 0.461301927911039 0.331715330180589 no 1092 0.322291000982187 1606 6251474
SGTC_279 1273-0055 2.93 µM 0.461154566428559 0.331763154784702 no 1093 0.322343857675455 1593 2847562
SGTC_2061 5245884 80.95 µM 0.460678024949651 0.33191783002771 no 1094 0.322514811640836 1521 573863
SGTC_1737 st035557 69.7 µM 0.460381202901013 0.332014186642872 no 1095 0.322621312227919 1488 5716916
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.459850400702431 0.332186527356764 no 1096 0.322811801832981 1507 688667
SGTC_1839 st053978 48 µM 0.459454065834422 0.332315232404215 no 1097 0.322954065316224 1554 3788398
SGTC_58 0957-0393 9 µM 0.459273727531696 0.332373801676806 no 1098 0.323018805909824 1503 6997992
SGTC_2293 7624732 200 µM 0.458970327680341 0.332472347431928 no 1099 0.323127737113349 1462 894453
SGTC_1059 3448-6867 171 µM 0.458953130190442 0.332477933607599 no 1100 0.323133912070661 1578 3934407
SGTC_1909 st060837 51.5 µM 0.455485375587992 0.333605105891219 no 1101 0.324380043185902 1505 678937
SGTC_2567 aureobasidin a 60 nM 0.455108993810135 0.333727537107477 no 1102 0.324515413987785 1616 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1285 0929-0069 65.5 µM 0.453995634796133 0.334089799319965 no 1103 0.324915984329609 1563 1206237
SGTC_398 bronopol 33.3 µM 0.451371166780666 0.334944354101719 no 1104 0.325861030327808 1590 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_145 3737-0113 38.366 µM 0.448341435536525 0.335931930432363 no 1105 0.326953400421088 1669 6849351
SGTC_2593 nobiletin 86.24 µM 0.448325071769454 0.335937267478098 no 1106 0.326959304418679 1514 72344 An anti-infammatory.
SGTC_1618 st003135 44.5 µM 0.44823949763728 0.33596517803637 no 1107 0.326990180011839 1544 1270615
SGTC_2053 5265679 138 µM 0.44462695378842 0.337144256086314 no 1108 0.328294682731402 1498 764595
SGTC_1340 1486-1359 257 µM 0.443335064490451 0.337566298030731 no 1109 0.328761698414946 1581 4309068
SGTC_478 N-arachidonylglycine 10 µM 0.442109871510854 0.337966740085931 no 1110 0.329204850700021 1556 5283389
SGTC_1016 4226-1401 38 µM 0.437377752755636 0.339515104711906 no 1111 0.33091870780269 1546 2901613
SGTC_1969 st069479 40.1 µM 0.434275513855294 0.340531641412765 no 1112 0.332044191381969 1651 3895485
SGTC_3315 9136395 68.55 µM 0.433990558880852 0.340625073261079 no 1113 0.332147648468185 1664 16876844
SGTC_1128 3448-9350 235 µM 0.433588946858632 0.340756771558828 no 1114 0.332293481330929 1566 619386
SGTC_2013 4024628 200 µM 0.431102244756652 0.341572653024261 no 1115 0.333197014259332 1613 5230760
SGTC_3162 9099653 49.47 µM 0.430336925999458 0.341823901674985 no 1116 0.333475284906042 1603 25237511
SGTC_2321 7390090 138.78 µM 0.430209619540929 0.341865702271789 no 1117 0.333521582554039 1496 649046
SGTC_2694 st077685 81.9 µM 0.429746800393244 0.34201768353024 no 1118 0.333689917748546 1525 2838096
SGTC_1442 4112-3290 3 µM 0.429701882028987 0.34203243525456 no 1119 0.333706257104554 1568 704353
SGTC_579 4491-1009 110 µM 0.427577663279639 0.342730328904751 no 1120 0.334479315548487 1748 1271041
SGTC_2210 7115885 190.385 µM 0.423139957227784 0.344190029542654 no 1121 0.336096575491336 1596 2927039
SGTC_2140 5586273 200 µM 0.422725219595861 0.344326568852268 no 1122 0.336247876544541 1588 854421
SGTC_1647 st011722 22.4 µM 0.421256313799121 0.344810322949098 no 1123 0.336783963477328 1612 2854783
SGTC_407 eburnamonine 100 µM 0.421040399315271 0.344881451386494 no 1124 0.336862790898226 1545 3195
SGTC_2915 7971052 15.16 µM 0.420880692505495 0.344934066927908 no 1125 0.336921102278175 1536 5741558
SGTC_1490 4089-0339 670 nM 0.420846468758349 0.344945342360066 no 1126 0.336933598397649 1680 742542
SGTC_312 4092-0653 6.84 µM 0.419875093727115 0.345265431129535 no 1127 0.337288351643935 1665 1148278
SGTC_1094 duloxetine 25.4 µM 0.419631726334016 0.345345643223837 no 1128 0.337377253872414 1598 60834 A selective serotonin reuptake inhibitor.
SGTC_1017 4239-0030 168 µM 0.419114118889134 0.345516265907888 no 1129 0.337566366312648 1516 1149593
SGTC_651 3253-0966 34.4 µM 0.418880253065952 0.34559336708807 no 1130 0.337651824711096 1572 781462
SGTC_2234 tolnaftate 200 µM 0.418795089971327 0.345621445355975 no 1131 0.337682946779027 1621 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1018 4259-0013 28.1 µM 0.418031342802176 0.345873290704126 no 1132 0.337962100734368 1621 6801262
SGTC_2536 dehydroabietamide 32.04 µM 0.414477551626087 0.347046047543704 no 1133 0.339262201950383 1728 3983547
SGTC_1788 fluconazole 20 µM 0.413842388432316 0.347255807222088 no 1134 0.339494769141289 1578 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3280 9140961 49.47 µM 0.413495751678984 0.347370302133725 no 1135 0.339621717175612 1593 4901226
SGTC_2441 5730946 39.09 µM 0.412380086156636 0.347738903518709 no 1136 0.340030428438569 1705 1774275
SGTC_1348 1493-0373 93.8 µM 0.411495571517969 0.348031237995876 no 1137 0.340354593915277 1638 3010129
SGTC_2908 7930301 100 µM 0.410181902686952 0.348465575774594 no 1138 0.340836257690645 1521 2223178
SGTC_2605 digitonin 300 nM 0.408700574326331 0.348955585169745 no 1139 0.341379706128749 1694 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1526 st051518 75 µM 0.4064349822461 0.349705508800102 no 1140 0.342211510222901 1604 673993
SGTC_3163 9099914 49.47 µM 0.40632348790752 0.349742429221856 no 1141 0.342252464786183 1673 16268368
SGTC_1138 3761-0006 1.03 µM 0.405237825493586 0.350102011528712 no 1142 0.342651351740619 1636 12061087
SGTC_61 0978-8327 98.565 µM 0.404061999243353 0.350491608656212 no 1143 0.343083564088707 1642 6150059 YHR072W ERG7
SGTC_1630 st005209 31.3 µM 0.403319786417384 0.350737613760666 no 1144 0.343356493803918 1692 3367314
SGTC_1271 0832-2808 169 µM 0.403188771400799 0.350781044954858 no 1145 0.34340467970196 1746 3663794
SGTC_938 3126-1755 342 µM 0.401575043659747 0.351316151978229 no 1146 0.343998399759615 1672 1777771
SGTC_2400 5203494 178.7 µM 0.401514890908469 0.351336104147507 no 1147 0.344020538509641 1579 6777674
SGTC_604 1000-0114 314 µM 0.40048318060259 0.35167837764172 no 1148 0.34440033460271 1719 1572745
SGTC_1609 st001574 46.4 µM 0.40042744025551 0.351696873123126 no 1149 0.344420858367806 1588 3960012
SGTC_433 pimozide 108 µM 0.398643323891855 0.352289054849437 no 1150 0.345078017126966 1522 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1999 st074831 12.5 µM 0.395842779237975 0.353219330422273 no 1151 0.346110507878096 1610 17112523
SGTC_1462 k081-0014 26.5 µM 0.394387461758506 0.353703099888136 no 1152 0.346647499647745 1531 3270634
SGTC_2903 5923464 63.88 µM 0.392737187779605 0.354251961786331 no 1153 0.347256800599979 1666 2876576
SGTC_2893 9048488 25.97 µM 0.391725299050172 0.3545886540668 no 1154 0.3476305975177 1570 6467338
SGTC_1186 1319-0216 26 µM 0.391379181722921 0.354703846020891 no 1155 0.347758489075195 1800 4565136
SGTC_1287 0971-0001 34.6 µM 0.390143320417777 0.355115263690157 no 1156 0.348215285418945 1673 4665869
SGTC_1961 st076550 68.7 µM 0.389484603518553 0.355334619309831 no 1157 0.348458848955702 1654 1579337
SGTC_2105 5350118 200 µM 0.388645546091469 0.355614098530634 no 1158 0.348769184706002 1602 2133313
SGTC_1554 st069299 38.7 µM 0.388520311946929 0.35565581907367 no 1159 0.348815512786214 1679 24207999
SGTC_194 1486-1323 56.904 µM 0.38758203786975 0.355968450981448 no 1160 0.349162681780958 1601 5178754
SGTC_980 1473-0395 201 µM 0.387347534019185 0.356046602550501 no 1161 0.349249469835589 1601 768876
SGTC_1409 3909-8004 61.9 µM 0.382701330860591 0.357596255646423 no 1162 0.350970613782055 1668 2119279
SGTC_1975 st070967 30.8 µM 0.381205250321113 0.358095746541794 no 1163 0.351525476774426 1763 261391
SGTC_2899 9053889 58.44 µM 0.380481332196006 0.35833752570828 no 1164 0.351794075607875 1752 6470052
SGTC_3212 9128307 49.47 µM 0.380477697201946 0.358338739892076 no 1165 0.351795424504055 1524 27243542
SGTC_474 dl-dihydrosphingosine 5 µM 0.37969658408454 0.35859968546095 no 1166 0.352085328060528 1712 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1292 0kpi-0043 232 µM 0.378456503436566 0.359014093370613 no 1167 0.352545750122153 1641 3333905
SGTC_1748 st037455 53.6035 µM 0.378103474646156 0.359132098264665 no 1168 0.352676863601154 1704 580690
SGTC_559 1550-0661 158 µM 0.377049607969098 0.359484448104039 no 1169 0.353068369519957 1712 5830875
SGTC_1332 1480-0653 17.5 µM 0.375521659197298 0.359995514749612 no 1170 0.353636270678613 1772 5749438
SGTC_237 nikkomycin 200 µM 0.372862480481516 0.36088555054675 no 1171 0.354625398890858 1751 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.372805687184158 0.360904567688138 no 1172 0.354646534878311 1706 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3116 9124943 49.47 µM 0.372584669466421 0.360978578376982 no 1173 0.354728792289081 1582 41905195 YPL160W CDC60
SGTC_2518 prenyletin 46.28 µM 0.371848404308672 0.361225163985696 no 1174 0.355002861095916 1757 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2587 piperic acid 92.2 µM 0.370885454028616 0.361547756674134 no 1175 0.355361424862822 1630 5370536
SGTC_723 4182-0001 115 µM 0.370417544440308 0.361704544050176 no 1176 0.355535701739859 1639 744821 YLR208W SEC13
SGTC_1960 st011366 51.8 µM 0.369770675784517 0.361921335353508 no 1177 0.355776683174421 1659 3972846
SGTC_2823 7987624 58.44 µM 0.367408361958343 0.362713416210322 no 1178 0.356657217579525 1672 2239440
SGTC_2429 5902844 64.44 µM 0.366600255743118 0.362984508320159 no 1179 0.356958608712488 1804 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_469 w7 172 µM 0.366427015686779 0.363042633401524 no 1180 0.357023231919289 1724 45115570 A P450 inhibitor.
SGTC_592 k241-0073 46.5 µM 0.365558235121234 0.363334172095807 no 1181 0.357347372307293 1755 4230158
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.364886798923879 0.36355954174338 no 1182 0.357597954430358 1576 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3227 9130768 49.47 µM 0.364743119771527 0.363607774234372 no 1183 0.357651583925206 1718 17720899
SGTC_732 3970-1727 52.7 µM 0.364295319316415 0.363758112841251 no 1184 0.357818747370703 1823 1275699
SGTC_2670 beta-carotene 100 µM 0.36382974020456 0.363914442463316 no 1185 0.357992576487405 1712 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2043 5101342 149 µM 0.363542269556794 0.364010979107334 no 1186 0.358099921543483 1698 678451
SGTC_1365 1672-3266 55.4 µM 0.363466167336349 0.364036536737094 no 1187 0.358128340921886 1775 6415873
SGTC_2361 9034121 116 µM 0.363246790649434 0.364110214031115 no 1188 0.358210268673701 1666 6496917
SGTC_362 0310-0100 9.03 µM 0.363032693481375 0.364182123050598 no 1189 0.358290231047564 1668 790235
SGTC_2028 5153890 36.43 µM 0.362058964803191 0.364509230522063 no 1190 0.358653983803063 1662 2830968 YPR165W RHO1
SGTC_6 0844-0013 19.835 µM 0.361489518739218 0.364700571922106 no 1191 0.358866769432589 1752 1584900
SGTC_3184 9108758 49.47 µM 0.359215073055028 0.365465151485218 no 1192 0.359717100731572 1680 902885
SGTC_1927 st060202 13.8 µM 0.357854289397209 0.365922849621771 no 1193 0.360226180068433 1810 688887
SGTC_200 k038-0079 37.545 µM 0.3556033696041 0.366680362867913 no 1194 0.361068809907709 1723 3436683
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.355016247390865 0.366878035584357 no 1195 0.361288709693209 1671 279621
SGTC_2475 5812728 15.03 µM 0.354256893971007 0.367133747575187 no 1196 0.361573184644491 1655 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2071 5230951 39.92 µM 0.354066900721583 0.367197736957828 no 1197 0.361644373386132 1729 1799272
SGTC_466 geldanamycin 89.2 µM 0.353778963738199 0.367294720643801 no 1198 0.361752269881492 1781 5288382 HSP90 inhibitor.
SGTC_88 0180-0332 8.668 µM 0.352774488090429 0.367633117003038 no 1199 0.362128755612808 1709 3101745
SGTC_2948 9070189 9.45 µM 0.352319590287977 0.36778640070372 no 1200 0.362299298966039 1816 6473636 YDL196W YDL196W
SGTC_1028 k015-0029 4.8 µM 0.352079698396084 0.36786724386382 no 1201 0.362389246589679 1661 4588309
SGTC_2924 9010168 62.78 µM 0.352030770983856 0.367883733037437 no 1202 0.362407592888211 1689 2993929
SGTC_1327 1436-0082 2.18 µM 0.350453519173264 0.368415417666444 no 1203 0.362999183643968 1719 15992205
SGTC_129 0088-0017 176.636 µM 0.349618745089109 0.368696918400673 no 1204 0.363312420591422 1809 182446
SGTC_3173 9105693 49.47 µM 0.348985758360579 0.368910419819312 no 1205 0.363550000702534 1770 17096658
SGTC_22 0964-0034 14.468 µM 0.347684158818608 0.369349566119588 no 1206 0.364038697370986 1686 138402
SGTC_517 1365-0151 113 µM 0.347168785702719 0.369523494870925 no 1207 0.36423225978538 1727 768657
SGTC_2620 irigenin 100 µM 0.347047215806291 0.36956452632255 no 1208 0.36427792372234 1801 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2324 6149169 200 µM 0.346981921896028 0.369586564496034 no 1209 0.364302450136977 1780 2888231
SGTC_1278 0874-0585 172 µM 0.346736811775759 0.369669298535377 no 1210 0.364394526045958 1750 766306
SGTC_1321 1326-2144 215 µM 0.345143122518528 0.37020737661477 no 1211 0.36499338795653 1803 3513030
SGTC_1534 6-azauridine 81.6 µM 0.344966202589991 0.37026712586557 no 1212 0.365059889646115 1718 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_219 mitoxanthrone 164.414 µM 0.342176487258499 0.371209679191012 no 1213 0.366109039428585 1788 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_191 3914-0123 66.505 µM 0.340874166268359 0.371649955765224 no 1214 0.366599156830695 1677 3144412
SGTC_891 0929-0073 133 µM 0.339304800618344 0.372180735410508 no 1215 0.367190063284206 1788 5603632
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.337252590476036 0.372875185714043 no 1216 0.367963247770652 1743 97141
SGTC_2038 4100038 30.985 µM 0.3363991101427 0.373164117960451 no 1217 0.368284960213774 1738 3596803
SGTC_3030 9087619 49.47 µM 0.334270086000097 0.373885175993635 no 1218 0.369087880675423 1692 25236973
SGTC_364 0083-0097 67.7 µM 0.333066172806086 0.374293113008834 no 1219 0.369542166572054 1728 5207356
SGTC_1573 oleylamine 1.06 µM 0.332694296014895 0.374419149168877 no 1220 0.369682527818269 1676 5356789 An amine of the fatty acid oleic acid.
SGTC_2849 9019321 12.99 µM 0.332116560522525 0.374614981397579 no 1221 0.369900622853305 1754 16489627
SGTC_1041 0206-0046 107 µM 0.330880961339633 0.375033915025395 no 1222 0.370367201686978 1724 50494
SGTC_2697 mebhydrolin 72.4 µM 0.33003627542556 0.375320393233614 no 1223 0.370686276261061 1866 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3119 9125183 49.47 µM 0.329723481489998 0.375426495858783 no 1224 0.370804454704763 1827 22695334
SGTC_3262 9137218 49.47 µM 0.329634185428202 0.375456787646705 no 1225 0.370838194391281 1738 17650664
SGTC_2486 5283202 22.39 µM 0.329120870753209 0.375630933610836 no 1226 0.371032164823783 1661 1377751
SGTC_3313 9133968 57.047 µM 0.328170742277608 0.375953338865301 no 1227 0.371391284112232 1754 1494643
SGTC_1714 st033236 13.627 µM 0.327731039436138 0.376102571706748 no 1228 0.371557516162378 1839 2916566
SGTC_1561 5-methoxyflavone 52.9 µM 0.327723128428872 0.376105256830921 no 1229 0.371560507181164 1826 94525
SGTC_1195 1502-0147 41.1 µM 0.327688327845964 0.376117068784402 no 1230 0.371573664788309 1712 817940
SGTC_1943 st076331 65.2 µM 0.32768644017954 0.376117709496183 no 1231 0.371574378492519 1861 24208415
SGTC_2363 9053361 176 µM 0.326879425787931 0.376391657594786 no 1232 0.371879541439101 1851 6469797 YMR079W SEC14
SGTC_2861 9024595 19.48 µM 0.326201503251227 0.376621832470736 no 1233 0.372135952058363 1781 16482810
SGTC_1670 st016595 4.04 µM 0.325848759153212 0.376741616947216 no 1234 0.37226939288432 1797 597879
SGTC_1720 st037298 9.481 µM 0.322196571793985 0.37798251849373 no 1235 0.373651890721666 1709 597396
SGTC_366 0181-0206 4.31 µM 0.321352316891383 0.378269550247145 no 1236 0.373971706938993 1915 274874
SGTC_567 1080-0542 68.4 µM 0.320661409842655 0.378504496440197 no 1237 0.374233497302311 1849 5950415
SGTC_2093 5331342 194.4 µM 0.319793753688717 0.378799610614708 no 1238 0.374562341503749 1854 33839
SGTC_939 1165-0479 45.3 µM 0.318262516637691 0.379320599587039 no 1239 0.375142907289839 1873 1377347
SGTC_2305 7443522 69.23 µM 0.317559920802838 0.37955972463171 no 1240 0.375409390033145 1820 5415886
SGTC_1113 artemisinin 1.17947 µM 0.317014935776728 0.37974523934606 no 1241 0.375616134613254 1895 2240 An anti-malaria and mitochondrial poison.
SGTC_227 fluconazole 33.516 µM 0.314179014982806 0.380711042120375 no 1242 0.376692539972926 1726 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2880 9042983 58.44 µM 0.312870169402439 0.381157034551625 no 1243 0.377189650981673 1751 6464714
SGTC_1863 st057641 20.1 µM 0.312474043557797 0.381292046585159 no 1244 0.377340143216659 1892 3921635
SGTC_2524 avocatin b 10.57 µM 0.311809593677351 0.381518544249344 no 1245 0.377592616300296 1863 6710748
SGTC_1235 benzylparaben 21.5 µM 0.309794066504395 0.382205845061083 no 1246 0.37835878201919 1780 7180
SGTC_180 1486-1293 102.781 µM 0.309273653403185 0.382383367893519 no 1247 0.378556685367755 1930 4140536
SGTC_1778 st046819 58.9 µM 0.308787863582038 0.382549102376144 no 1248 0.378741450879427 1750 671715
SGTC_391 gliotoxin 8.33 µM 0.305991224637298 0.383503635252879 no 1249 0.379805663630624 1816 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2721 ifenprodil 61.44 µM 0.303024263082816 0.384517075085786 no 1250 0.380935685554845 1857 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_166 k072-0058 166.424 µM 0.302437335578915 0.384717648625304 no 1251 0.381159348407244 1890 5846229
SGTC_1854 st056233 32.9 µM 0.302335980267579 0.384752288386126 no 1252 0.38119797631053 1914 5393174
SGTC_2003 4023581 200 µM 0.302037846825494 0.38485418547906 no 1253 0.381311605926535 1761 16641307
SGTC_1429 4049-0205 9.46 µM 0.301930078873135 0.384891020745089 no 1254 0.381352682773795 1806 22774478
SGTC_1379 2144-0755 36.5 µM 0.300609536887212 0.385342468469148 no 1255 0.38185612913714 1910 5392327
SGTC_3350 9150499 3.57 µM 0.300586492029981 0.385350348091875 no 1256 0.381864916586677 1772 4910996 YPR165W RHO1
SGTC_385 1494-0393 12.4 µM 0.299833390038379 0.385607878842967 no 1257 0.382152122408111 1819 3090647
SGTC_560 2332-1943 155 µM 0.298465012666277 0.386075938168043 no 1258 0.382674137860835 1783 21177716
SGTC_834 0312-0008 75.7 µM 0.29761366556454 0.386367228827586 no 1259 0.382999021679048 1771 6385573 YIL048W NEO1
SGTC_3188 9110789 49.47 µM 0.296332384825122 0.386805743111022 no 1260 0.38348812822441 1883 849217
SGTC_577 r071-0003 38.6 µM 0.292302500994565 0.388185897980645 no 1261 0.385027673380363 1747 4568517 YMR134W ERG29
SGTC_311 1315-0136 58 µM 0.2920385403548 0.388276348742601 no 1262 0.385128578398289 1871 6759207
SGTC_3334 9142812 21.919 µM 0.291416897969807 0.388489389386499 no 1263 0.385366246199319 1858 45283678
SGTC_1738 st035555 74 µM 0.290665964224966 0.38874678370589 no 1264 0.385653402397796 1813 5331140
SGTC_1910 st062352 60.4 µM 0.290504980004083 0.388801969934967 no 1265 0.385714970742928 1715 2245730
SGTC_159 3970-0959 50 µM 0.289221603692375 0.38924199818088 no 1266 0.386205900309049 1880 6615653
SGTC_1030 k029-0042 36.7 µM 0.288726324708962 0.389411851357358 no 1267 0.386395408014953 1809 6080581
SGTC_2339 9000433 200 µM 0.288242020484861 0.389577961234073 no 1268 0.386580742676163 1719 2988954
SGTC_2835 9006588 71.43 µM 0.286794697478247 0.39007449380737 no 1269 0.387134761636226 1759 2345538
SGTC_464 bw-b 70c 158 µM 0.285181976969821 0.390627980548061 no 1270 0.387752363793381 1898 5353454
SGTC_3204 9114183 49.47 µM 0.28512320649288 0.390648154807737 no 1271 0.387774875716885 1722 17027248
SGTC_1942 st076330 65.2 µM 0.28244827251119 0.391566695570897 no 1272 0.388799902477328 1854 24208414
SGTC_2691 st077356 60.2 µM 0.280790378565389 0.392136300767985 no 1273 0.38943559183177 1888 2839272
SGTC_2065 5221596 34.26 µM 0.280766120309357 0.392144636933951 no 1274 0.389444895421038 1835 788581
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.280478295348643 0.392243549578968 no 1275 0.389555287631277 1868 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2091 4-phenylthiadiazole 200 µM 0.278983498392949 0.392757356691278 no 1276 0.390128744286689 1806 270010
SGTC_1743 st037606 46.3785 µM 0.275127323325183 0.394083702320163 no 1277 0.391609210165961 1812 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1897 st060201 15 µM 0.275082075576396 0.394099272776928 no 1278 0.391626591086559 1769 611878
SGTC_1089 terbinafine 2.25 µM 0.27462754997573 0.39425569151819 no 1279 0.39180119902589 1931 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_666 0272-0154 136 µM 0.27295716672968 0.39483067729525 no 1280 0.392443070828435 1853 6870312
SGTC_2956 9076196 2.52 µM 0.272353282993244 0.3950386049498 no 1281 0.392675195059475 1913 16423868
SGTC_2843 9000894 45.46 µM 0.271844664645583 0.39521375427184 no 1282 0.392870730268048 1821 2242070
SGTC_2313 7726885 200 µM 0.27109629739423 0.395471502722894 no 1283 0.393158484619371 1826 726423
SGTC_1572 epiandrosterone 68.9 µM 0.268840153427533 0.396248827485867 no 1284 0.39402634623626 1872 441302 A steroid.
SGTC_1692 fluoroquinolonic acid 71 µM 0.268448723738899 0.396383731535962 no 1285 0.394176969601074 1878 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3089 9117425 49.47 µM 0.268100980804653 0.396503589598282 no 1286 0.394310795444143 1772 9401657
SGTC_3291 9121177 71.43 µM 0.267939220987292 0.396559347388533 no 1287 0.394373051555488 1798 17015612
SGTC_1252 0493-0875 34.8 µM 0.267411611854776 0.3967412262824 no 1288 0.394576129957643 1795 3960963
SGTC_3355 9151058 44.0485 µM 0.266979851244917 0.396890080723026 no 1289 0.39474233728531 1913 17015728
SGTC_3351 9150312 21.596 µM 0.266256729196153 0.397139419017905 no 1290 0.395020747830877 1911 4904905
SGTC_1848 st056003 16.4 µM 0.265474837103506 0.397409069006135 no 1291 0.395321845856387 2024 146492
SGTC_3224 9130643 49.47 µM 0.263420010307773 0.398117947588654 no 1292 0.396113434543357 1890 17644395
SGTC_1821 st053465 65.6 µM 0.262884310080439 0.39830280998896 no 1293 0.396319874923193 1828 675086
SGTC_1438 4092-1045 4 µM 0.262701288640114 0.398365973274542 no 1294 0.396390411736213 1837 1351342
SGTC_2799 7812892 81.82 µM 0.261754910110702 0.398692624329371 no 1295 0.396755201890981 1941 20205235
SGTC_288 1315-0019 35.1 µM 0.261329323903274 0.398839542384323 no 1296 0.396919277417673 1863 6811474
SGTC_2047 4141938 200 µM 0.259765701069875 0.399379448844719 no 1297 0.397522254750658 1849 3807862
SGTC_2789 5281112 71.43 µM 0.257030418214204 0.400324382487427 no 1298 0.398577645681132 1785 765948
SGTC_383 2324-0395 7.37 µM 0.256902191785684 0.400368694089164 no 1299 0.39862713927771 1910 3146421
SGTC_3228 9131799 49.47 µM 0.255602572597376 0.400817879770239 no 1300 0.399128865866672 1870 17015818
SGTC_2185 6113692 200 µM 0.254953790042085 0.401042166758731 no 1301 0.399379395094145 1866 874150
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.253809878783151 0.401437701337074 no 1302 0.399821220570855 1840 15053
SGTC_1153 4055-0057 267 µM 0.253328663831647 0.401604123082767 no 1303 0.400007123904122 1803 882706
SGTC_343 4130-2827 29.8 µM 0.253101437856916 0.401682712347997 no 1304 0.400094913898904 1804 1118244
SGTC_1651 st011928 86.1 µM 0.253092518582609 0.401685797284255 no 1305 0.400098360012197 1893 720198
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.252008571661869 0.402060750828861 no 1306 0.400517219179305 1829 5355888
SGTC_581 0958-0271 211 µM 0.250667357665824 0.402524821678473 no 1307 0.401035649929269 1817 4591145
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.248794671738379 0.403173015819491 no 1308 0.401759806440018 1861 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1976 st070609 63.5 µM 0.24749031177795 0.403624652238893 no 1309 0.40226439421049 1908 682556
SGTC_212 3807-4682 38.772 µM 0.246521521597206 0.403960180390447 no 1310 0.402639273292253 1956 3125501 YBL034C STU1
SGTC_2278 7948257 134.34 µM 0.245427244750884 0.404339254241077 no 1311 0.403062817853998 2034 1247028
SGTC_1303 1160-0052 261 µM 0.241008218572632 0.405870981268473 no 1312 0.40477437337585 1980 3562476
SGTC_2447 5741742 33.78 µM 0.240883803706977 0.40591412704911 no 1313 0.404822587675392 1917 1776504
SGTC_1400 3771-8998 51.5 µM 0.240403821008978 0.40608059075843 no 1314 0.405008608158699 1924 670767
SGTC_733 4069-0007 56.1 µM 0.237183766512899 0.407197781615436 no 1315 0.406257114743747 1919 5717425 YNL287W SEC21
SGTC_556 4058-0063 51.5 µM 0.236729420727481 0.407355476912557 no 1316 0.406433354583824 1879 6615692
SGTC_715 0868-0130 184 µM 0.236614439286868 0.407395387296329 no 1317 0.406477958666489 2030 2876258
SGTC_1407 3909-7909 12.3 µM 0.23655179823342 0.407417130587984 no 1318 0.406502259157337 1888 4411780
SGTC_788 1182-0090 188 µM 0.236496465363572 0.407436337378488 no 1319 0.406523724866894 1994 5715185
SGTC_3127 9126946 49.47 µM 0.235795953137808 0.407679513911354 no 1320 0.406795504278345 1808 27243249
SGTC_1229 0139-0193 12.2 µM 0.235737558184279 0.407699786803116 no 1321 0.406818161937766 2016 3090752
SGTC_600 1495-0418 41.6 µM 0.235466214896292 0.407793991902671 no 1322 0.406923449164056 1894 5377768
SGTC_2005 4024620 188 µM 0.235197744546101 0.407887204821343 no 1323 0.407027628247439 1893 236743
SGTC_574 1315-0397 40 µM 0.233532316211009 0.408465557920611 no 1324 0.407674039232634 1946 6794277
SGTC_359 0081-0058 15.9 µM 0.231529477310616 0.409161347573842 no 1325 0.408451743943401 1993 3494159
SGTC_78 0336-0123 156.75 µM 0.230007713533586 0.409690202439608 no 1326 0.409042887932361 1815 6765896
SGTC_1523 st012844 44.7 µM 0.228300669557751 0.410283642837259 no 1327 0.409706252035439 1902 4274103
SGTC_1061 3448-9325 110 µM 0.227675233730939 0.410501122189605 no 1328 0.409949363715846 2035 723482
SGTC_1372 2752-0194 270 µM 0.227628006959621 0.410517545212869 no 1329 0.409967722529317 1894 823334
SGTC_3305 9127027 53.8275 µM 0.22730100765974 0.410631262923563 no 1330 0.410094844807221 1906 41905295
SGTC_1513 0337-0559 19 µM 0.224316217582224 0.411669603598677 no 1331 0.411255628957467 1847 775073
SGTC_1751 st044839 27.194 µM 0.224117466507339 0.411738766640228 no 1332 0.411332950919603 2022 5291326
SGTC_2351 9026858 72.31 µM 0.223918130123796 0.411808136116721 no 1333 0.411410504049262 1853 1409300
SGTC_2050 5263056 171 µM 0.223418004748226 0.411982192917235 no 1334 0.411605096343854 2034 763468 YGL055W OLE1
SGTC_2353 9059630 146.67 µM 0.222449946544414 0.41231915183697 no 1335 0.411981816968598 1984 4779114
SGTC_871 0574-0004 149 µM 0.221798668317209 0.412545883281311 no 1336 0.412235308085666 1898 9551173
SGTC_2735 sertaconazole 140 nM 0.221603143765258 0.412613957530124 no 1337 0.412311417485472 2012 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_460 trequinsin 123 µM 0.221059408955142 0.412803279224221 no 1338 0.412523087671021 2005 5537 A vasodilator.
SGTC_839 0122-0028 230 µM 0.219865963711473 0.413218893070039 no 1339 0.412987772355761 1934 759448
SGTC_2247 cerulenin 830 nM 0.219815432392917 0.413236492604905 no 1340 0.413007450130517 1995 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_90 0870-0863 4.608 µM 0.218062469986953 0.4138471389517 no 1341 0.413690219173716 1869 1738164
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.217982536126192 0.413874988977189 no 1342 0.413721359203189 2022 16623 A steroid.
SGTC_931 2812-0076 566 µM 0.21757928378691 0.414015494084161 no 1343 0.413878463471775 1863 3450959
SGTC_690 glyoxal 20.3 µM 0.217538695788111 0.414029636759934 no 1344 0.413894277033937 1951 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2319 6033012 152.6 µM 0.217282471267254 0.414118919426082 no 1345 0.413994108345575 1872 847246
SGTC_752 1896-0090 130 µM 0.216500997854459 0.414391254988569 no 1346 0.41429862371459 1908 772567
SGTC_2890 9046729 58.44 µM 0.216091424463694 0.414534003611529 no 1347 0.414458242046868 1850 903329
SGTC_923 1900-2434 73.3 µM 0.215693115418923 0.414672837098968 no 1348 0.414613484005427 1861 5910570
SGTC_421 streptovitacin 30 mM 0.215336674194526 0.414797086293992 no 1349 0.414752419184202 1872 91467 include heat shock
SGTC_3068 9116768 49.47 µM 0.215310444317381 0.414806229908622 no 1350 0.414762643598913 1921 41904888
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.214155181399215 0.415208994968338 no 1351 0.415213022646024 1801 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3023 9089636 49.47 µM 0.213666674633202 0.415379332348077 no 1352 0.415403500481143 2085 17249241
SGTC_2935 9038016 29.96 µM 0.213436320173363 0.415459660143859 no 1353 0.415493326852153 2051 6463195
SGTC_1037 k284-1091 78.7 µM 0.213320314754747 0.415500114180569 no 1354 0.415538564660964 1877 3334711
SGTC_3330 9141424 71.43 µM 0.212745096156521 0.415700720743283 no 1355 0.415762895097105 2020 27261020
SGTC_792 4534-1957 155 µM 0.212265243159331 0.415868085517181 no 1356 0.415950054754455 1935 1717904
SGTC_3342 9147791 14.508 µM 0.21170214633564 0.416064503817382 no 1357 0.41616970676027 1961 1838168
SGTC_1862 st057513 3.81 µM 0.209724705347778 0.416754436584907 no 1358 0.416941271123637 1927 5393163
SGTC_3261 9137475 49.47 µM 0.208648725254547 0.417129955892712 no 1359 0.41736123517666 2043 17027690
SGTC_89 0302-0250 142.109 µM 0.206882431980443 0.41774655973396 no 1360 0.4180508384795 2059 4203518 YLR208W SEC13
SGTC_3250 9135583 49.47 µM 0.206739268964513 0.417796546084078 no 1361 0.418106743827955 2053 7699353
SGTC_1316 1272-0050 65.9 µM 0.205785887351358 0.418129459655966 no 1362 0.41847908276554 1941 7340392
SGTC_872 0588-0139 234 µM 0.204662880190631 0.418521680409592 no 1363 0.418917761890754 1954 2047100
SGTC_2386 9075165 157.42 µM 0.204392738148639 0.41861604214799 no 1364 0.419023302262853 1973 16452277
SGTC_1479 0549-0158 134 µM 0.203251891213691 0.419014596314061 no 1365 0.419469077930342 1933 5440202
SGTC_3159 9100096 49.47 µM 0.202649603523844 0.419225038695344 no 1366 0.41970445815188 2005 25236875
SGTC_3041 9091929 49.47 µM 0.202505689637208 0.419275326362012 no 1367 0.419760705434207 2004 25236887
SGTC_1206 3978-0017 132 µM 0.202289685438096 0.419350806939724 no 1368 0.419845131559982 1987 3873677
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.201659801996797 0.419570930551089 no 1369 0.420091345132647 1936 65057 A dermal irritant. YDR527W RBA50
SGTC_1480 1070-0044 41.2 µM 0.199858340808597 0.420200620881705 no 1370 0.42079568613727 2049 3124987
SGTC_785 1270-0111 65.3 µM 0.199649520285663 0.420273626131367 no 1371 0.420877347893295 2084 6741994
SGTC_2196 6573537 42.6665 µM 0.199458328634884 0.420340470598127 no 1372 0.420952118654317 2060 2903087
SGTC_331 k048-0133 24.5 µM 0.19844434750802 0.420695017259647 no 1373 0.421348711501115 1933 6813582
SGTC_291 SEC14.278 35.5 µM 0.198027353488081 0.420840841261513 no 1374 0.421511831254539 2041 1068044
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.197670166112009 0.42096575934667 no 1375 0.421651566552328 1975 7104
SGTC_947 3447-0010 211 µM 0.197330794411498 0.421084454180575 no 1376 0.421784341319231 2027 748350
SGTC_963 1269-2853 151 µM 0.19628717096116 0.421449505095956 no 1377 0.422192701082654 1912 3668223
SGTC_447 ml7 120 µM 0.195001604000618 0.421899278657066 no 1378 0.422695845958332 2083 4216 Selective myosin light chain kinase inhibitor.
SGTC_353 1988-1175 58.3 µM 0.194460993136409 0.422088449387736 no 1379 0.422907467827474 1896 2788357
SGTC_2372 9071633 200 µM 0.19333203237674 0.422483553625493 no 1380 0.423349470661414 2108 21321366
SGTC_1369 1866-0067 208 µM 0.192255475104247 0.422860390796888 no 1381 0.423771046725847 2064 3531355
SGTC_73 0327-0325 16.231 µM 0.190684738659537 0.423410336572906 no 1382 0.424386298041871 2100 53298
SGTC_859 0439-0102 54.6 µM 0.190373251465398 0.423519412142601 no 1383 0.424508328301166 2093 610143
SGTC_3130 9127414 49.47 µM 0.19014930948593 0.423597835036655 no 1384 0.424596065747065 2119 1494646
SGTC_1364 1653-0028 37.6 µM 0.189784147942885 0.423725718510579 no 1385 0.424739139123673 1973 5718652
SGTC_2412 st077135 33.4 µM 0.188152006410179 0.424297409930947 no 1386 0.425378746905697 2042 13258915
SGTC_2088 5278280 127.392 µM 0.18794777835096 0.424368956283517 no 1387 0.425458794180155 1987 791502
SGTC_2602 kawain 100 µM 0.187806544625747 0.424418435555234 no 1388 0.42551415259602 2104 5369129
SGTC_247 mechlorethamine 29.705 µM 0.185968949315429 0.425062319813647 no 1389 0.426234555695208 1978 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3036 9090181 49.47 µM 0.185912883808284 0.425081968040682 no 1390 0.426256539262478 1980 25236586
SGTC_1932 st074806 40.9 µM 0.185857122919223 0.425101509698513 no 1391 0.426278403614744 2019 17251235
SGTC_1454 4239-0054 42.6 µM 0.185481921581985 0.425233005501035 no 1392 0.426425529363759 2069 1340767
SGTC_698 k064-0052 127 µM 0.185278066818835 0.425304453419407 no 1393 0.426505470166014 2049 5088751
SGTC_507 nimesulide 162 µM 0.184987719563026 0.425406219843614 no 1394 0.426619333853573 2082 4495 A COX2 inhibitor.
SGTC_2803 7707263 71.43 µM 0.184677651599612 0.425514903843764 no 1395 0.426740938041894 1943 2199229
SGTC_1635 st007035 42.4 µM 0.184332952305066 0.425635733346992 no 1396 0.426876132312527 2045 3716403
SGTC_2872 9044037 25.97 µM 0.183853695372547 0.425803741745735 no 1397 0.427064115612467 2023 6465195
SGTC_1201 1889-3372 45.9 µM 0.183725459451671 0.425848698439447 no 1398 0.427114417563337 1973 5392199
SGTC_3006 9075424 71.4286 µM 0.18236661726526 0.426325137733729 no 1399 0.427647511019653 1938 7465181
SGTC_657 3534-0529 86.7 µM 0.180637546429606 0.426931542556335 no 1400 0.428326041429474 2079 1049549
SGTC_3088 9117578 49.47 µM 0.180528118857945 0.426969925877753 no 1401 0.428368990683119 2095 678341
SGTC_618 k072-0232 33.2 µM 0.180123267785655 0.427111939322182 no 1402 0.428527898149298 2002 5872756 YGL099W LSG1
SGTC_2026 5148700 152 µM 0.179700445879173 0.427260266651296 no 1403 0.428693871690782 1965 79838
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.177920681397084 0.427884726448736 no 1404 0.429392634287142 2077 91467 include heat shock
SGTC_1703 st026983 48.3 µM 0.176904428551809 0.428241376699605 no 1405 0.429791730003372 2107 1104023
SGTC_2783 7738165 71.43 µM 0.176188402586103 0.42849269863633 no 1406 0.430072965830251 1910 17201110
SGTC_2677 mitomycin C 100 µM 0.17585634911219 0.42860925778189 no 1407 0.430203399594712 2009 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1590 st077108 57.8 µM 0.175329525802958 0.428794198826575 no 1408 0.430410356426922 2097 5489485
SGTC_285 1486-1325 46 µM 0.173486209490475 0.429441416848598 no 1409 0.431134633378794 2084 22310230
SGTC_2205 7238770 200 µM 0.172089322727398 0.429932012723003 no 1410 0.431683653384231 2107 279867
SGTC_590 k048-0076 22.4 µM 0.171500460017197 0.430138857668872 no 1411 0.431915134379726 2103 6832814
SGTC_1798 st045719 60.953 µM 0.170514536812693 0.430485217676472 no 1412 0.432302751523992 2087 3980186
SGTC_2722 naftopidil 47.16 µM 0.169999711683831 0.43066609972596 no 1413 0.432505181696364 2078 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_920 mycophenolic acid 780.421 nM 0.169770083054152 0.430746783653725 no 1414 0.432595477805914 1971 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1721 st082152 9.2685 µM 0.168491264958884 0.431196170945585 no 1415 0.433098407494114 2074 5296051
SGTC_2755 lomerizine 42.69 µM 0.167622457158106 0.431501528073642 no 1416 0.433440151456911 1984 3949 A calcium channel blocker.
SGTC_2933 9026794 32.47 µM 0.16595998522449 0.432085945792529 no 1417 0.434094220286185 2047 17586027
SGTC_137 0438-0332 85.389 µM 0.165707788545459 0.432174614866858 no 1418 0.434193458214256 2088 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_962 1254-0300 21.5 µM 0.165651013806889 0.432194576598278 no 1419 0.43421579931619 2003 7340576
SGTC_3052 9092717 49.47 µM 0.16561655740742 0.432206691390902 no 1420 0.434229358158894 2003 25237534
SGTC_2069 5228469 200 µM 0.164626678962592 0.432554757603917 no 1421 0.434618915474126 2008 2835210
SGTC_1827 berberine 7.24 µM 0.163874816587132 0.432819166359827 no 1422 0.434914846257092 1875 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1637 st007924 17.4 µM 0.163522984508172 0.432942906101254 no 1423 0.435053338845393 2042 683336
SGTC_56 0957-0365 83.25 µM 0.162825635571281 0.433188183934308 no 1424 0.435327861676699 2113 6752360
SGTC_2390 9097792 176.6 µM 0.161833720954467 0.433537113375709 no 1425 0.435718398786583 1944 4497149
SGTC_2580 diallyl disulphide 81.36 µM 0.161026893879719 0.433820972116077 no 1426 0.436036109394997 1996 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1045 1348-1485 165 µM 0.160942387754026 0.433850705126407 no 1427 0.436069388424846 2122 6810614
SGTC_2267 7931562 200 µM 0.16024407976769 0.434096415218116 no 1428 0.43634440368848 1872 934880
SGTC_588 3970-1144 52.9 µM 0.159973226998567 0.434191725668437 no 1429 0.436451082169361 2118 1888707
SGTC_1075 aripiprazole 15.2 µM 0.159169203439235 0.434474676237617 no 1430 0.436767783300627 2012 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2391 6285546 200 µM 0.159102920693762 0.434498003845551 no 1431 0.436793893576215 1946 846083
SGTC_1563 conessine 56.1 µM 0.158162242453897 0.434829091522843 no 1432 0.437164477683705 2117 441082 An anti-amoebic, histamine inhibitor.
SGTC_2807 7945238 51.95 µM 0.156894261126103 0.435275451364201 no 1433 0.437664091401577 2033 17148797
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.156182278845495 0.435526122402725 no 1434 0.437944672374134 2031 6708760
SGTC_2173 5763948 167 µM 0.154766590235458 0.436024627603169 no 1435 0.438502665463309 2132 2867177
SGTC_2847 9005661 71.43 µM 0.154177016324291 0.436232263779762 no 1436 0.43873508190624 2154 2991449
SGTC_2483 5729050 27.16 µM 0.154015869529363 0.436289019528628 no 1437 0.438798611403905 2129 2865180
SGTC_2004 4023728 41.89 µM 0.152194144306848 0.43693072039312 no 1438 0.439516906165102 2147 360084 YDR527W RBA50
SGTC_189 3970-0742 2.116 µM 0.150503571713323 0.437526371403112 no 1439 0.440183666507966 2153 2891807
SGTC_456 gingerol 170 µM 0.150319941493537 0.437591079645469 no 1440 0.440256100354055 2082 442793 A herb.
SGTC_382 3229-0966 23.2 µM 0.149257057476988 0.437965655074008 no 1441 0.440675399403149 2133 5722370
SGTC_965 1291-5240 308 µM 0.148694971787085 0.43816376455076 no 1442 0.440897164530934 2110 2834598
SGTC_1985 st071382 65.5 µM 0.148134925395566 0.43836117068204 no 1443 0.441118143509598 2163 6123237
SGTC_95 0471-0001 561.058 µM 0.147302550375179 0.438654596007848 no 1444 0.441446609765444 1949 4015405
SGTC_3282 9108498 15.4605 µM 0.147211010981055 0.438686867149377 no 1445 0.441482734890321 2021 16459645
SGTC_280 3448-3607 3.04 µM 0.146504689231974 0.438935886302514 no 1446 0.441761494194743 2149 626179
SGTC_1719 st032227 49.2 µM 0.145159954233071 0.439410049682429 no 1447 0.442292291436367 2028 3125804
SGTC_18 0111-0177 500 nM 0.14413162855144 0.439772703527214 no 1448 0.442698264750189 2104 721752
SGTC_2213 7173844 200 µM 0.144016928311108 0.439813157355753 no 1449 0.442743551065059 2110 892728
SGTC_3292 9120825 59.784 µM 0.143416241037802 0.440025025055099 no 1450 0.442980728534924 2179 24824900
SGTC_420 mitomycin C 81.9 mM 0.142524937070676 0.440339427457617 no 1451 0.443332691747981 2022 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_484 loperamide 105 µM 0.142477180288918 0.440356274454206 no 1452 0.443351551483883 2154 3955 An opioid-receptor agonist.
SGTC_1661 st013063 9.66 µM 0.141631761438657 0.440654527817163 no 1453 0.443685438909329 2114 721395
SGTC_3254 9136651 49.47 µM 0.14070404330802 0.440981854092614 no 1454 0.444051875389426 2139 16454030
SGTC_2099 5377090 177.372 µM 0.1393836684393 0.441447790710585 no 1455 0.444573488539597 2040 2243829
SGTC_2793 7325131 81.82 µM 0.137919430248257 0.44196458886157 no 1456 0.445152047021131 2078 4176441
SGTC_1838 st055369 84.5 µM 0.137828639288331 0.441996636500304 no 1457 0.445187924743717 2169 676036
SGTC_1962 st076595 64.5 µM 0.137091598657892 0.442256813129562 no 1458 0.445479196535193 2104 279619
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.136174441601658 0.442580605943282 no 1459 0.445841689791449 2164 165521
SGTC_2856 9022925 19.48 µM 0.133624486045938 0.443481042294837 no 1460 0.446849760382515 2093 4944862
SGTC_223 busulfan 5 mM 0.133148318030059 0.443649218490065 no 1461 0.447038041519983 2135 2478 A DNA alkylator.
SGTC_1405 3909-7894 12 µM 0.132672208836272 0.443817384057824 no 1462 0.447226311334039 2167 7104060
SGTC_1238 0333-0287 48.8 µM 0.128818284473573 0.445178990706703 no 1463 0.44875071857933 2100 7226
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.127569753559854 0.445620241125364 no 1464 0.449244734339451 2216 688664
SGTC_3024 9090631 49.47 µM 0.127567619232938 0.445620995487827 no 1465 0.449245578912469 2213 25236383
SGTC_1159 4092-0538 61.2 µM 0.127292472044505 0.445718245925756 no 1466 0.449354459139183 2181 717301
SGTC_2130 NSC 7 2.4545 µM 0.126552596692467 0.445979770149107 no 1467 0.44964725876622 2167 21448
SGTC_783 0848-0141 92.7 µM 0.124855556282265 0.446579712728812 no 1468 0.450318951952985 2190 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2216 7189485 200 µM 0.124677196095419 0.446642774257919 no 1469 0.45038955569658 2172 731273
SGTC_2844 9010103 25.97 µM 0.124495680938055 0.446706952652612 no 1470 0.450461409944798 2065 2480525
SGTC_2975 9084847 53.72 µM 0.123654803749244 0.44700428015772 no 1471 0.450794299152249 2035 27211724
SGTC_516 3992-2719 87.3 µM 0.122260031239395 0.447497526263273 no 1472 0.451346542462877 2148 5350887 YDR037W KRS1
SGTC_1286 0929-0070 131 µM 0.120377074144594 0.448163542208468 no 1473 0.45209222575485 2134 1420408
SGTC_2734 clemastine 41.6 µM 0.118868920922239 0.448697092729327 no 1474 0.452689602329206 2210 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2492 derrusnin 100 µM 0.11779245599112 0.44907797850534 no 1475 0.453116053589804 2097 1715307 Part of coumarin class of compounds.
SGTC_273 hydroxyurea 18.1 mM 0.117068799734974 0.449334056327109 no 1476 0.453402766947903 2186 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1811 st050069 61.5 µM 0.116692926253273 0.449467073754702 no 1477 0.453551698005005 2224 3877702
SGTC_1219 1469-0211 33.1 µM 0.116374416968871 0.449579795079025 no 1478 0.453677904957453 2208 6822282
SGTC_647 0140-0236 81 µM 0.114671837102432 0.450182411627311 no 1479 0.454352618688916 2130 990837
SGTC_1836 st055642 81 µM 0.110950953594191 0.45149979100371 no 1480 0.455827619934277 2120 8571
SGTC_3050 9093513 49.47 µM 0.110117182777213 0.451795061481723 no 1481 0.456158220571506 2176 25236664
SGTC_3166 9102297 49.47 µM 0.109991759549122 0.451839481006926 no 1482 0.456207955094314 2091 25237072
SGTC_2362 9071156 126 µM 0.109334129347925 0.452072395259578 no 1483 0.456468738770656 2188 653133
SGTC_3230 9131665 49.47 µM 0.107572638013711 0.452696347351035 no 1484 0.457167351357209 2157 15943720
SGTC_1993 st073995 70.8 µM 0.1073809193383 0.452764264650615 no 1485 0.457243395568723 2139 3098394
SGTC_1653 st012112 65 µM 0.106762969677643 0.452983185804301 no 1486 0.457488512716219 2207 720429
SGTC_422 cantharidin 155 µM 0.106440354489487 0.453097484435933 no 1487 0.457616488332807 2189 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_727 3032-0951 202 µM 0.105940410896456 0.453274616034922 no 1488 0.457814815601012 2139 3652836
SGTC_2263 7948595 193.29 µM 0.105075825956351 0.453580963139367 no 1489 0.458157820595488 2179 2971371
SGTC_2309 7664088 163.95 µM 0.105032244522598 0.453596406017222 no 1490 0.458175111394653 2245 704922
SGTC_3293 9120939 62.045 µM 0.104555517844636 0.453765336469492 no 1491 0.458364256392093 2173 934087
SGTC_246 cycloheximide 667 µM 0.103932311507725 0.453986185323442 no 1492 0.458611532539238 2120 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2619 obliquin 87.91 µM 0.102385482553985 0.454534404443326 no 1493 0.459225353178605 2181 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1929 genistein trimethyl ether 50.5 µM 0.0998660442604854 0.455427515710742 no 1494 0.460225337151012 2249 136420
SGTC_2451 5856223 45.7 µM 0.0994323592110478 0.45558127481969 no 1495 0.460397495563442 2149 2179896
SGTC_2699 st077704 54.6 µM 0.0989702546063645 0.455745117145964 no 1496 0.460580943754644 2148 645852
SGTC_2274 7947094 46.08 µM 0.0982705745735388 0.455993207770247 no 1497 0.460858721575357 2256 2971028
SGTC_36 0335-0881 14.2 µM 0.0965861388797782 0.456590540545851 no 1498 0.461527532297931 2182 23828853
SGTC_2207 7258803 200 µM 0.0915436269837494 0.458379291829205 no 1499 0.463530321210735 2224 3666799
SGTC_381 3461-2219 42.7 µM 0.0898664338273326 0.458974438211034 no 1500 0.464196677558537 2244 2883159
SGTC_1056 3448-1962 115 µM 0.0896800840415136 0.459040569510142 no 1501 0.464270721396516 2168 715507
SGTC_1211 1056-0033 32.3 µM 0.0891220803272364 0.459238599103963 no 1502 0.464492444826861 2249 6741922
SGTC_2244 6635614 200 µM 0.0877890111469266 0.459711732056257 no 1503 0.46502218593849 2091 836499
SGTC_1393 3470-5649 58.2 µM 0.0875961472880766 0.459780188043247 no 1504 0.465098832214245 2177 4108395
SGTC_377 3970-0964 33.1 µM 0.0874809200464732 0.459821087900596 no 1505 0.465144625439564 2210 16481235
SGTC_1801 st050089 28.441 µM 0.0865805684721066 0.460140681892094 no 1506 0.465502456001357 2254 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3322 9139058 2.11 µM 0.0859929302952732 0.460349287233723 no 1507 0.465736018608021 2209 4908926 YPR165W RHO1
SGTC_2445 5742597 35.57 µM 0.085895917027305 0.46038372696958 no 1508 0.465774578628342 2164 1774255
SGTC_57 miconazole 162.5 nM 0.0851584745225416 0.460645528951714 no 1509 0.466067701570619 2248 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0851234148824845 0.460657976019969 no 1510 0.466081637740213 2255 551469
SGTC_1022 4477-0945 21.3 µM 0.0849914955659386 0.46070481109416 no 1511 0.46613407590061 2222 4648966
SGTC_2335 9018011 154.17 µM 0.0832869267402501 0.461310029850226 no 1512 0.466811697563422 2217 6458208
SGTC_1384 3089-0840 101 µM 0.082820081657985 0.461475802064453 no 1513 0.466997300564256 2246 1069836
SGTC_3076 9116187 49.47 µM 0.0817397402551513 0.461859446561869 no 1514 0.46742683796206 2239 27241210
SGTC_951 1171-0579 82.7 µM 0.0813283294075455 0.462005553717604 no 1515 0.46759042249942 2252 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1430 4049-0248 69.1 µM 0.0809479829593906 0.462140633321791 no 1516 0.467741660128695 2255 22774488
SGTC_296 1222-0039 74.9 µM 0.080455922330943 0.462315394565586 no 1517 0.467937325711467 2177 5984176
SGTC_451 chloral hydrate 100 µM 0.0789635249813646 0.462845481768965 no 1518 0.468530817643429 2168 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1971 st069429 63.5 µM 0.0788539828956388 0.462884392823281 no 1519 0.468574382770414 2272 1246522 YGL099W LSG1
SGTC_2744 captopril 92.04 µM 0.0786668709150186 0.46295085873316 no 1520 0.468648798484279 2266 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2977 9011197 71.43 µM 0.078465555214402 0.463022371242909 no 1521 0.468728864337867 2251 2704722
SGTC_1604 st002052 72.4 µM 0.0784200053968569 0.46303855187439 no 1522 0.468746980264031 2188 6254834 YHR062C RPP1
SGTC_3001 9076041 71.4286 µM 0.0773414011172972 0.463421721567478 no 1523 0.469175978096861 2252 16004211
SGTC_1503 4585-0012 61.3 µM 0.0769306060714568 0.463567663745241 no 1524 0.469339374782171 2232 2922052
SGTC_1380 2291-0730 164 µM 0.0768269173834387 0.463604501754276 no 1525 0.46938061852119 2176 2999191
SGTC_1168 k815-0004 80.5 µM 0.0763095349948906 0.463788319491383 no 1526 0.469586420068088 2239 642433
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0760326876699443 0.463886682122016 no 1527 0.469696546228924 2242 688751
SGTC_812 4251-0442 148 µM 0.0759571570468956 0.463913518202003 no 1528 0.469726591702797 2267 5723007
SGTC_2808 7946468 45.46 µM 0.0756955261967411 0.46400647708354 no 1529 0.469830667680606 2220 2970879
SGTC_2110 5483698 200 µM 0.0755782408329944 0.464048149857203 no 1530 0.469877324120686 2185 2848765 YHR062C RPP1
SGTC_1015 4130-4525 82 µM 0.0749743562707384 0.464262722886639 no 1531 0.470117557592258 2102 1363237
SGTC_1688 st021091 57.6 µM 0.0738293114669508 0.46466961014963 no 1532 0.470573101743505 2285 3656366
SGTC_2537 larixol 68.93 µM 0.0735439172102205 0.464771029668753 no 1533 0.47068664889543 2252 6708759
SGTC_3086 9117350 49.47 µM 0.0735118012524003 0.464782442743279 no 1534 0.470699426721478 2284 2679265
SGTC_2928 9011484 9.79 µM 0.0731208872980072 0.464921364478851 no 1535 0.470854960244041 2206 2994751
SGTC_1777 st045864 34.765 µM 0.0726806531598014 0.465077818579888 no 1536 0.471030122183659 2283 4691462
SGTC_1939 st074455 53.6 µM 0.0723768168334345 0.465185801632638 no 1537 0.471151016943115 2289 1644229
SGTC_1311 1190-0148 100 µM 0.0699824814634133 0.466036834516536 no 1538 0.472103801606879 2262 1961333
SGTC_3217 9129673 49.47 µM 0.0694910757573914 0.466211517112401 no 1539 0.472299367998219 2243 17248312
SGTC_3290 9121031 71.43 µM 0.0688300891780899 0.466446491782389 no 1540 0.472562433587927 2226 17014854
SGTC_17 0960-0276 49.807 µM 0.0662390848874816 0.467367682073091 no 1541 0.473593739923565 2304 6821114
SGTC_1907 st060210 83.7 µM 0.0650882896039 0.467776885352702 no 1542 0.474051852102011 2248 688793
SGTC_234 nsc-17383 10.7 µM 0.0641373638562405 0.468115044130022 no 1543 0.474430425511269 2283 408974
SGTC_716 1683-5115 658 µM 0.063699130265056 0.468270892170406 no 1544 0.474604898645127 2315 723597
SGTC_102 gallobenzophenone 83.616 µM 0.0634357882442432 0.468364546249974 no 1545 0.474709744864547 2297 70837
SGTC_1067 clotrimazole 1.36 µM 0.0622234280694025 0.468795728490351 no 1546 0.475192452867654 2224 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1127 asiatic acid 681.4 nM 0.0608430496283828 0.46928671184268 no 1547 0.47574210258135 2254 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2382 9035899 200 µM 0.0603282812915486 0.46946982050082 no 1548 0.475947088874133 2293 6462679
SGTC_821 1114-0266 29.2 µM 0.0601800691030596 0.469522542376224 no 1549 0.476006109745662 2238 3123235
SGTC_372 0155-0182 15.9 µM 0.0598036295993459 0.469656451419281 no 1550 0.476156017375531 2223 771486
SGTC_1116 jasmonic acid 1.58368 µM 0.0590517250647413 0.46992393311976 no 1551 0.476455454657387 2291 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1930 st074634 34.3 µM 0.0589453996513111 0.469961758304676 no 1552 0.476497798600057 2306 684253 YOR116C RPO31
SGTC_1463 k081-0032 34.1 µM 0.0580901823364862 0.470266011042947 no 1553 0.476838397274544 2271 977755
SGTC_2946 9065502 71.43 µM 0.057139224436037 0.470604344897705 no 1554 0.477217145433157 2318 16489101
SGTC_2661 dactinomycin 12.96 µM 0.0568113746877041 0.470720992920327 no 1555 0.477347726441666 2317 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2415 st077333 57.7 µM 0.0564159562801407 0.47086168502408 no 1556 0.477505222962909 2333 2766255
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0560604080805072 0.470988194188464 no 1557 0.477646842042872 2277 688664
SGTC_840 0245-0196 390 µM 0.0560034652532835 0.471008455537906 no 1558 0.477669523311449 2269 3827528
SGTC_3117 9124945 49.47 µM 0.0550909485733629 0.471333156665874 no 1559 0.478033003593486 2263 17592065
SGTC_2832 7992762 51.95 µM 0.0544888065684271 0.47154742751496 no 1560 0.478272863203157 2226 2985177
SGTC_2827 7993847 71.43 µM 0.0540007904947953 0.471721092958931 no 1561 0.478467267219283 2258 2985692
SGTC_1050 3232-1156 69.3 µM 0.0534212688033855 0.471927328581469 no 1562 0.478698129676254 2235 700529
SGTC_2404 5161160 200 µM 0.0534070686097267 0.471932382129434 no 1563 0.478703786658243 2283 2831543
SGTC_1732 st034308 51.822 µM 0.0528766660673845 0.472121144382432 no 1564 0.478915088081051 2285 830119
SGTC_3271 9137798 49.47 µM 0.0519035840025628 0.472467465842726 no 1565 0.479302759253084 2309 6498326
SGTC_2340 7987427 183.45 µM 0.0509088183100663 0.47282152605541 no 1566 0.479699089314061 2301 2239331
SGTC_774 k060-0086 136 µM 0.0503174057910704 0.473032033702854 no 1567 0.47993472676154 2308 5911235
SGTC_64 000l-0018 272.079 µM 0.0498903774919178 0.473184035040492 no 1568 0.480104872702437 2296 6811119
SGTC_2461 5755302 26.15 µM 0.0496576148110964 0.473266888897361 no 1569 0.480197616621479 2310 2788904
SGTC_2998 9066762 71.4286 µM 0.0492554895270225 0.473410031536947 no 1570 0.480357845322623 2279 4945196
SGTC_399 oxolinic acid 75 µM 0.0485444807558346 0.473663134364562 no 1571 0.480641157844989 2215 4628 A DNA gyrase inhibitor.
SGTC_2521 angolensin 13.4 µM 0.048376169417895 0.473723050903622 no 1572 0.480708225556621 2264 821428 A flavenoid.
SGTC_2491 paeonol 100 µM 0.0468015970493285 0.474283605786338 no 1573 0.481335678084395 2250 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3157 9099274 49.47 µM 0.0457496168065432 0.474658143950822 no 1574 0.481754908345178 2317 17217662
SGTC_3352 9151559 45.5865 µM 0.0454978048068331 0.474747800304091 no 1575 0.481855262299409 2285 17159339
SGTC_675 1309-0189 238 µM 0.0451612305189814 0.474867637825522 no 1576 0.481989398133062 2289 4246530
SGTC_1519 esterone 74 µM 0.0446522034244125 0.47504888161133 no 1577 0.48219226590469 2271 698 A steroid.
SGTC_2647 atorvastatin 60.16 µM 0.0446362411898772 0.475054565195662 no 1578 0.482198627572036 2290 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_356 1634-0012 32.5 µM 0.0445548753145249 0.475083536770545 no 1579 0.482231055598007 2337 735457
SGTC_2926 9010726 65.15 µM 0.0445537747226725 0.475083928654153 no 1580 0.482231494235047 2282 2994293
SGTC_2957 9076800 11.52 µM 0.044362028931251 0.47515220322561 no 1581 0.482307914178686 2288 16459615
SGTC_3192 9110362 49.47 µM 0.0441076654428642 0.475242775090952 no 1582 0.482409291296583 2335 16649480
SGTC_1758 st042942 75.2445 µM 0.0432139001123371 0.47556103053864 no 1583 0.482765512376283 2324 669317
SGTC_150 3970-0969 77.2 µM 0.040450015125603 0.476545303265714 no 1584 0.483867178273938 2235 6615640
SGTC_904 1141-0088 396 µM 0.0397446369086098 0.47679652520991 no 1585 0.484148357332445 2277 1378119
SGTC_684 1140-0066 328 µM 0.038753348695251 0.477149590168552 no 1586 0.48454351960893 2278 6813534
SGTC_654 1124-0271 80.9 µM 0.0386000107095229 0.477204205833016 no 1587 0.484604646877768 2312 5403748
SGTC_1231 0242-0792 125 µM 0.0372367506221408 0.477689788212457 no 1588 0.485148118080858 2321 3707635
SGTC_2276 7947513 42.08 µM 0.0367316867924818 0.477869696371341 no 1589 0.485349471638607 2165 2105100
SGTC_2478 5763493 32.33 µM 0.0364562203221925 0.477967821843282 no 1590 0.485459293303416 2313 1365576 YLR208W SEC13
SGTC_3248 9135562 49.47 µM 0.0345493908206722 0.478647100683704 no 1591 0.486219528827847 2330 17650701
SGTC_1673 st016611 27.3 µM 0.0328004091024275 0.479270203254162 no 1592 0.486916875986507 2311 5226799
SGTC_2991 9074669 71.4286 µM 0.0327354469981972 0.479293348022877 no 1593 0.486942778206683 2336 17333109
SGTC_1835 st008666 49.2 µM 0.0323972744405341 0.479413833633261 no 1594 0.487077618015019 2307 690455
SGTC_863 0466-0191 129 µM 0.0308343368296206 0.479970708203293 no 1595 0.48770082830062 2356 765160 YPR165W RHO1
SGTC_841 0251-0215 91.2 µM 0.0304081803090035 0.480122554572935 no 1596 0.487870760465377 2288 3888614
SGTC_2241 6772625 37.8075 µM 0.028374173541682 0.480847343004891 no 1597 0.4886818612169 2363 2285411
SGTC_1752 st044819 83.042 µM 0.0283021568604482 0.480873006266067 no 1598 0.488710580182211 2332 441209 YML126C ERG13
SGTC_1389 3405-0187 19 µM 0.0275381545273688 0.481145264597072 no 1599 0.489015254232592 2336 799890
SGTC_906 1165-0455 526 µM 0.0260367512329522 0.481680327153067 no 1600 0.489614012567107 2375 3252859
SGTC_1905 st060207 84.5 µM 0.0256288951798946 0.481825682582865 no 1601 0.489776669307559 2327 1948547
SGTC_1696 st025591 34.7925 µM 0.0253037607642311 0.481941558658853 no 1602 0.489906337118409 2371 2787147
SGTC_2297 7971671 152.32 µM 0.0234214745540766 0.482612424546595 no 1603 0.490657037743255 2352 909016
SGTC_472 calcifediol 10 µM 0.0219855032109827 0.483124252499418 no 1604 0.49122975975292 2297 5283731 A vitamin D metabolite.
SGTC_3049 9092223 49.47 µM 0.0219758732934939 0.483127685017164 no 1605 0.491233600606196 2342 8623917
SGTC_497 capsazepine 133 µM 0.0215227395663848 0.48328920282191 no 1606 0.491414332056105 2359 2733484 A calcium channel blocker.
SGTC_308 4092-1169 104 µM 0.019397654398104 0.484046717554179 no 1607 0.49226194078832 2364 2268590 YDL196W YDL196W
SGTC_1729 st035615 45.989 µM 0.0185686896292899 0.484342228780127 no 1608 0.492592590292166 2235 17385451
SGTC_2120 5538279 151.968 µM 0.0182536118146931 0.484454550692849 no 1609 0.492718266851379 2367 2058197
SGTC_2147 5545932 89.7195 µM 0.0173784019231459 0.484766560218866 no 1610 0.493067369661427 2358 797404
SGTC_2610 ononetin 44.17 µM 0.0164649973403836 0.485092195973727 no 1611 0.493431713188429 2350 259632
SGTC_205 1486-1330 71.903 µM 0.0136206523011293 0.486106289548397 no 1612 0.49456631392249 2375 4118834
SGTC_274 sirtinol 40.1 µM 0.0131990537654862 0.486256609766086 no 1613 0.494734492280522 2368 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2416 tofa 880 nM 0.0130467045802191 0.486310930082066 no 1614 0.494795265578742 2361 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2513 baicalein 25.65 µM 0.0126354517645064 0.486457564116474 no 1615 0.494959318187564 2378 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_183 3914-0051 30.55 µM 0.0114289621212331 0.486887753896827 no 1616 0.495440603047914 2374 1596232
SGTC_667 1498-1044 59 µM 0.0111551388746911 0.486985391326005 no 1617 0.4955498357536 2363 6739982
SGTC_2522 biochanin a 4.94 µM 0.0103901256309808 0.487258176980022 no 1618 0.495855014165711 2381 5280373 A possible chelator.
SGTC_1476 4112-3294 3.34 µM 0.0100753584829952 0.487370417248916 no 1619 0.495980581514817 2381 704369
SGTC_2338 7999974 200 µM 0.00932481247235041 0.487638052394276 no 1620 0.496279991958479 2385 315925
SGTC_3028 9087778 49.47 µM 0.00913435082694401 0.487705969480931 no 1621 0.496355971925259 2396 17217395
SGTC_2765 myclobutanil 7.74 µM 0.00869131871929928 0.487863952533289 no 1622 0.496532709143108 2372 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3082 9117008 49.47 µM 0.00704628628082745 0.488450579409826 no 1623 0.497188961744197 2387 41448529
SGTC_3125 9127534 49.47 µM 0.00690130509632038 0.488502281649161 no 1624 0.497246799462057 2397 1639235
SGTC_753 1322-0200 289 µM 0.00639779688913247 0.488681840939548 no 1625 0.497447665731458 2389 5403907
SGTC_1398 3558-0053 112 µM 0.00599728192534007 0.488824672788955 no 1626 0.49760744501483 2391 4532369
SGTC_970 1315-0089 19.5 µM 0.00593069797488282 0.488848418130553 no 1627 0.497634007695448 2390 6811083 YLR033W RSC58
SGTC_1708 st033234 31.827 µM 0.0043184051313756 0.489423410066127 no 1628 0.498277210963801 2392 674664
SGTC_3176 9106582 49.47 µM 0.00400036205103419 0.489536836391334 no 1629 0.498404090697459 2397 17018027
SGTC_226 1,3-diallylurea 8.28947 mM 0.00333975164361752 0.489772438019722 no 1630 0.498667634340176 2381 74537 YKL182W FAS1
SGTC_1529 apigenin 74 µM 0.00225984804341503 0.49015758499281 no 1631 0.499098451835554 2403 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_32 0928-0142 34.1 µM 0.00155396905315562 0.490409341294858 no 1632 0.49938005629177 2404 2244242
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.000756189682026594 0.490693879055641 no 1633 0.499698323992587 2404 5393153
SGTC_561 1550-0330 72.9 µM 0.000479591696900247 0.490792532219762 no 1634 0.499808670602112 2404 6812934
SGTC_1258 0671-0043 57.1 µM 0 0.490963587719849 no 1635 0.5 2405 4298767
SGTC_1690 st023502 41.2 µM 0 0.490963587719849 no 1636 0.5 2405 24207482
SGTC_989 1501-0895 10.3 µM -0.00155707424428097 0.49151895915749 no 1637 0.49937881750124 2408 2830112
SGTC_996 3970-0799 1.8 µM -0.00192591540612489 0.491650518497012 no 1638 0.499231671390995 2373 6615648 YGL040C HEM2
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.00371772278816053 0.492289638232733 no 1639 0.49851684660955 2413 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2846 9008642 19.48 µM -0.0040774052634571 0.492417935805152 no 1640 0.498373355153302 2416 2992898
SGTC_3320 9137005 35.139 µM -0.00444848159092081 0.492550298349555 no 1641 0.498225318462988 2414 4908713
SGTC_2330 7979373 200 µM -0.00453611301816587 0.492581556509805 no 1642 0.498190358934336 2408 1863007
SGTC_2417 cerulenin 830 nM -0.00540323134954975 0.492890860341778 no 1643 0.497844433052476 2409 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3114 9122766 49.47 µM -0.00585571700093541 0.493052265103595 no 1644 0.49766392025674 2423 17176985
SGTC_2927 9011802 47.9 µM -0.00615526311079667 0.493159115900421 no 1645 0.497544420803981 2424 43912568
SGTC_1947 st076332 61.6 µM -0.0077327849438415 0.493721840073678 no 1646 0.496915095884816 2419 24208416
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.00833605856285374 0.493937039601925 no 1647 0.496674432302966 2419 17037758
SGTC_1033 k072-0102 21.3 µM -0.00842525008973189 0.493968856119564 no 1648 0.496638851281397 2420 5965931
SGTC_2455 5377712 9.75 µM -0.00987929394105771 0.494487549801586 no 1649 0.496058796057048 2441 2243908
SGTC_1098 clofazimine 15.1 µM -0.0102395044160835 0.494616047330199 no 1650 0.495915100140081 2457 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2266 7929956 200 µM -0.0108433631432225 0.494831462506718 no 1651 0.495674208750613 2420 2967153
SGTC_529 4076-0302 30.3 µM -0.0108797667875289 0.494844448866901 no 1652 0.495659686654377 2426 5816522
SGTC_2636 apigenin dimethyl ether 100 µM -0.0114979291362371 0.495064968241306 no 1653 0.495413090997428 2448 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1169 aniline yellow 25.8 µM -0.0115524512908013 0.495084418207459 no 1654 0.495391341249314 2436 6051 A DNA damaging agent.
SGTC_1071 trifluoperazine 6.31 µM -0.0117193679992987 0.495143963328278 no 1655 0.495324755624879 2448 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3037 9091026 49.47 µM -0.0121299053644764 0.495290417051234 no 1656 0.495160986557521 2428 25236398 YIL048W NEO1
SGTC_2512 diallyl trisulfide 49.23 µM -0.0123834230947519 0.495380856434459 no 1657 0.495059855212908 2421 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2696 st077691 74.316 µM -0.0126600367374459 0.495479535275701 no 1658 0.494949510986834 2449 757133
SGTC_1317 1273-0028 910 nM -0.012986385071384 0.495595956770223 no 1659 0.494819327542645 2436 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1449 4112-4002 201 µM -0.0135079635259579 0.495782025426608 no 1660 0.494611266103832 2444 2059539
SGTC_2906 7926292 26.41 µM -0.0142769331845998 0.49605635044293 no 1661 0.494304521204541 2439 2966319
SGTC_2206 7254556 146.969 µM -0.0147916517890488 0.496239974068781 no 1662 0.494099199880748 2429 4398905
SGTC_3131 9127911 49.47 µM -0.0161475670296473 0.496723694651759 no 1663 0.493558332725071 2459 45595681
SGTC_1557 sumaresinolic acid 42.3 µM -0.0162785080826074 0.496770407928357 no 1664 0.493506101668089 2432 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_807 1315-0151 48 µM -0.017597522905046 0.497240969391602 no 1665 0.492979966403639 2433 4011080
SGTC_110 0850-0284 111.64 µM -0.0181188187684663 0.497426943941765 no 1666 0.492772032604647 2432 3906265
SGTC_2256 7954252 200 µM -0.0183819708940759 0.49752082481375 no 1667 0.492667067578036 2470 2972920
SGTC_624 k048-0052 28 µM -0.0197908047039876 0.498023435715959 no 1668 0.492105126615782 2456 6835531
SGTC_412 gemfibrozil 100 µM -0.0207191795207273 0.498354641417282 no 1669 0.491734834629278 2443 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_877 0771-0151 33.1 µM -0.0207385984333887 0.49836156929431 no 1670 0.491727089268196 2485 6166523
SGTC_2862 9027634 71.43 µM -0.0210892938437899 0.498486683214528 no 1671 0.491587212636046 2442 5012562
SGTC_2002 4023503 131 µM -0.0215625897395866 0.498655536256662 no 1672 0.49139843782571 2435 4736863 YCR052W RSC6
SGTC_71 0417-1750 47.813 µM -0.0216778842636349 0.498696668768297 no 1673 0.491352452714167 2444 6811472
SGTC_1277 0873-0036 22 µM -0.0224906278712277 0.498986623808287 no 1674 0.491028293992964 2468 5965735
SGTC_1991 st073000 8.92 µM -0.0227743784529329 0.499087855019856 no 1675 0.490915122877756 2464 4301969 YIL048W NEO1
SGTC_2011 4012611 177 µM -0.0230211943709901 0.499175909422729 no 1676 0.490816683382538 2452 2049887
SGTC_2937 9044753 11.33 µM -0.0247433564173607 0.499790311317504 no 1677 0.490129836117485 2456 6465530 YGL099W LSG1
SGTC_1677 st019204 53.9 µM -0.02517210393604 0.499943272253586 no 1678 0.489958843868805 2512 3945625
SGTC_1266 0828-0227 32.9 µM -0.0254901181913832 0.499943272253586 no 1679 0.4898320152344 2472 3913820
SGTC_631 k072-0230 41.5 µM -0.0254921631307485 0.499942542696348 no 1680 0.48983119968664 2478 5773147
SGTC_2881 9058953 51.95 µM -0.0256393606296067 0.499890028181127 no 1681 0.48977249556871 2451 17122249
SGTC_322 k048-0136 19.3 µM -0.0261430372391376 0.499710335385784 no 1682 0.489571625014135 2498 6823282
SGTC_439 amiodarone 34.4 µM -0.0263894164705955 0.499622436598476 no 1683 0.489473367822328 2505 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_861 0443-0273 110 µM -0.026442147104219 0.499603624305853 no 1684 0.489452338681385 2514 6149169
SGTC_2407 paclitaxel 400 µM -0.0266637786354699 0.499524554581101 no 1685 0.489363951657643 2649 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_115 0527-0192 112.043 µM -0.0267132428617982 0.499506907623567 no 1686 0.489344225312953 2483 4233931
SGTC_1171 0368-0077 21.4 µM -0.0268864990114042 0.499445096416682 no 1687 0.489275130927015 2449 3239779
SGTC_811 0416-0114 265 µM -0.0278142424430745 0.499114113096865 no 1688 0.488905153265461 2496 6612453
SGTC_2817 7995342 71.43 µM -0.0286566538021064 0.498813573514152 no 1689 0.488569213705792 2464 18879975
SGTC_1029 k015-0030 64.7 µM -0.0288347801677648 0.498750025040809 no 1690 0.488498180921206 2547 2208316
SGTC_2655 perillic acid 100 µM -0.0288665382845998 0.498738694998519 no 1691 0.488485516537419 2462 5702197 An apoptosis inducer.
SGTC_1816 st051957 91.6 µM -0.0289114546569244 0.498722670611891 no 1692 0.488467604973241 2456 674121
SGTC_1363 1636-0063 10.4 µM -0.0291646421612556 0.498632343355175 no 1693 0.488366640349241 2460 6072185
SGTC_1198 1612-1005 86.7 µM -0.029701209170089 0.498440917771354 no 1694 0.488152673785097 2493 6998509
SGTC_2990 9074105 71.4286 µM -0.0297309753665034 0.498430298396678 no 1695 0.488140804032748 2465 6502001
SGTC_162 k030-0015 37.8 µM -0.0305294506168518 0.498145435169272 no 1696 0.487822403063724 2480 1809920 YMR134W ERG29
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0319170293030255 0.497650406326836 no 1697 0.487269109069123 2551 61125 An anti-inflammatory.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0320839349604037 0.497590861741828 no 1698 0.487202557429825 2510 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2985 9022375 71.43 µM -0.0338888468965008 0.496946952389549 no 1699 0.486482893484158 2605 4939335
SGTC_2592 piperlongumine 83.33 µM -0.0341486322243233 0.496854273578962 no 1700 0.486379314085602 2505 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1329 1447-1697 50.6 µM -0.0342360758927212 0.496823077955285 no 1701 0.486344449495488 2536 2840515
SGTC_2058 5236698 133 µM -0.0343120685939833 0.496795967492341 no 1702 0.486314150595428 2480 766665
SGTC_3242 9133940 49.47 µM -0.0343734190521266 0.496774080673284 no 1703 0.486289689732876 2567 17248444
SGTC_2242 6630449 61.2675 µM -0.0360136976876815 0.496188913927134 no 1704 0.485635718432243 2621 691249 YDR170C SEC7
SGTC_2695 st077686 51.995 µM -0.0360326573894113 0.496182150129768 no 1705 0.48562815951168 2489 2876092
SGTC_1200 1643-0193 18.4 µM -0.0378061370208015 0.4955494735193 no 1706 0.484921125618525 2448 5403974
SGTC_1652 st011932 78 µM -0.0383562339572035 0.49535323243654 no 1707 0.484701827763019 2472 1551076
SGTC_2853 9015042 58.44 µM -0.0383982135649856 0.495338256714869 no 1708 0.484685092650931 2479 6457456
SGTC_3064 1327-0027 10 µM -0.039701808067779 0.494873218383005 no 1709 0.484165430092709 2484 16000455 YPR107C YTH1
SGTC_2487 5918373 44.05 µM -0.0397033840282229 0.494872656186184 no 1710 0.484164801870783 2477 2876279
SGTC_1617 st002906 78 µM -0.0398688162690893 0.494813641132429 no 1711 0.484098856169933 2486 5150859
SGTC_3299 9121982 43.1275 µM -0.0399165819405765 0.494796601586984 no 1712 0.484079815580915 2505 17594604 YPL160W CDC60
SGTC_42 0133-0086 60.653 µM -0.0400954967214305 0.494732777036804 no 1713 0.48400849600607 2483 162923 Model of phenazepam hydroxylation.
SGTC_202 3594-0513 34.79 µM -0.0425226513622224 0.493866948355182 no 1714 0.483041027451636 2469 708429
SGTC_1020 4335-0961 93.3 µM -0.0432227786806505 0.493617200066484 no 1715 0.4827619736464 2478 669075
SGTC_452 diindolylmethane 8 µM -0.0435342106923583 0.493506107339318 no 1716 0.482637847089003 2525 3071 Inhibits expression of several cancer promoting factors.
SGTC_2202 7226349 200 µM -0.0449078586970166 0.493016111484101 no 1717 0.482090376415757 2479 844334
SGTC_1990 st072050 59.8 µM -0.0466461728073899 0.492396050283268 no 1718 0.481397615740217 2479 17233948
SGTC_262 fenpropimorph 62.5 µM -0.0480806567618087 0.491884379866645 no 1719 0.480825981021017 2488 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_776 4476-4378 112 µM -0.0500859518145296 0.491169127682451 no 1720 0.480026947257855 2575 2892008
SGTC_669 0108-0021 26.2 µM -0.0503753367332966 0.491065911648367 no 1721 0.479911644931308 2480 17201
SGTC_328 k915-0120 63.5 µM -0.0508151162862934 0.490909054928228 no 1722 0.479736422692246 2583 6624543
SGTC_1417 3966-0327 90.4 µM -0.0517460788205026 0.490577012031045 no 1723 0.479365510403984 2497 651118
SGTC_1611 st001856 99.4 µM -0.0529241173704319 0.490156854851504 no 1724 0.478896184219291 2501 647478
SGTC_415 dibenzyl ketone 100 µM -0.0531830442239398 0.490064507898314 no 1725 0.478793032621877 2595 7593
SGTC_207 4185-0010 4.486 µM -0.0539466425394574 0.489792171641637 no 1726 0.478488837686036 2496 3761753
SGTC_50 0929-0078 56.389 µM -0.0540361056778088 0.489760265049169 no 1727 0.478453199040043 2602 1377751
SGTC_3222 9128301 49.47 µM -0.05445315859179 0.489611526027123 no 1728 0.478287063605691 2529 4911358
SGTC_781 4335-2806 94.4 µM -0.0544809610031513 0.489601610541554 no 1729 0.47827598848855 2644 845254
SGTC_2089 5281248 129.67 µM -0.0546750436561724 0.489532392849114 no 1730 0.47819867594597 2504 2737878
SGTC_881 0833-0569 170 µM -0.0553919735347879 0.489276709523119 no 1731 0.47791309510653 2503 5418700
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0557648424807179 0.489143732601651 no 1732 0.477764571488761 2494 6708784 An antioxidant flavonoid
SGTC_67 0335-0847 266 µM -0.0564294785463509 0.488906705250778 no 1733 0.477499836939283 2716 4552207 YOR254C SEC63
SGTC_615 k087-0205 167 µM -0.0573057830241646 0.488594197172041 no 1734 0.477150806869215 2526 9642773
SGTC_1527 coumarin 137 µM -0.0577432955267882 0.488438173884562 no 1735 0.476976553182793 2708 323 A hepatotoxic, DNA x-linker.
SGTC_658 3253-0951 102 µM -0.059905162334944 0.487667247339788 no 1736 0.476115584166351 2548 1184878
SGTC_982 1491-0518 27.5 µM -0.0623651037229248 0.486790082942005 no 1737 0.475136042018942 2566 3091256
SGTC_51 1013-0126 23.419 µM -0.0633385321073364 0.486442995854428 no 1738 0.474748466580768 2507 1627850
SGTC_323 4013-0906 34.3 µM -0.0649771592017917 0.485858747843832 no 1739 0.474096093065878 2616 2910086
SGTC_2815 7968870 71.43 µM -0.0658100320803331 0.48556180085194 no 1740 0.473764534553968 2537 2977326 YHR190W ERG9
SGTC_1410 3909-8106 77.9 µM -0.0658247894510655 0.485556539428206 no 1741 0.47375865995281 2558 1039210
SGTC_826 1683-5028 118 µM -0.066982875725085 0.485143656542814 no 1742 0.473297667885797 2583 722377
SGTC_3339 9145883 14.936 µM -0.0681959865426161 0.484711173301183 no 1743 0.472814810905308 2544 2030670
SGTC_1700 st030840 7.9285 µM -0.0693060568747688 0.484315440522465 no 1744 0.472373002322017 2623 5499307
SGTC_1954 st077032 68.9 µM -0.0693605956066158 0.48429599821792 no 1745 0.472351296749253 2607 698907
SGTC_3118 9124250 49.47 µM -0.0694836822232621 0.484252119676605 no 1746 0.472302310479124 2597 1504786
SGTC_2516 gossypol 71.55 µM -0.0712972862733833 0.48360561929494 no 1747 0.471580577487589 2582 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2306 7482397 179.52 µM -0.0721796458025824 0.483291097667577 no 1748 0.471229471606608 2571 891448
SGTC_763 3453-1109 128 µM -0.078409054208698 0.481070899806338 no 1749 0.468751335744829 2540 1560353
SGTC_510 ag-490 170 µM -0.0787775725505135 0.480939575412278 no 1750 0.468604771554553 2541 5328779
SGTC_2920 7982904 15.77 µM -0.0788741189780543 0.480905170678901 no 1751 0.468566374578169 2620 6456808
SGTC_1378 2093-0007 380 nM -0.0795971777928488 0.480647510109245 no 1752 0.468278819945669 2615 3618014
SGTC_1853 st056710 91.2 µM -0.0802210087039734 0.480425215698478 no 1753 0.468030740739477 2702 269167
SGTC_2855 9016525 58.44 µM -0.0819854946572006 0.479796496191715 no 1754 0.467329124104017 2545 43811474
SGTC_1065 prochlorperazine maleate 2.48 µM -0.0823283526968128 0.479674335211827 no 1755 0.467192804376438 2547 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3146 9095609 49.47 µM -0.0829861745478728 0.479439957374488 no 1756 0.466931266402477 2612 17173999
SGTC_2413 inermin 26.06 µM -0.0851649643553345 0.478663719316614 no 1757 0.466065121873558 2774 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1130 3454-2858 15.9 µM -0.0857483762895059 0.478455880596342 no 1758 0.465833222499531 2667 715628 YIL048W NEO1
SGTC_1420 4'-methoxyflavone 42 µM -0.0861427488237409 0.478315389900338 no 1759 0.465676470627623 2550 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2448 5185112 27.17 µM -0.0866705457204206 0.478127372523343 no 1760 0.465466694700941 2652 5718189
SGTC_62 0180-0423 3.232 µM -0.0870934792720543 0.477976714184274 no 1761 0.465298604239453 2589 30102 YGL099W LSG1
SGTC_2961 9083290 32.55 µM -0.0883386183509567 0.477533186299394 no 1762 0.464803772956126 2542 17741490
SGTC_2629 bisabolol 100 µM -0.0894007813767011 0.477154857829725 no 1763 0.464381701255358 2645 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2262 9014885 67.46 µM -0.0894229975029146 0.477146944957031 no 1764 0.464372873659966 2615 6457424
SGTC_3111 9122088 49.47 µM -0.0920495633848531 0.476211487021893 no 1765 0.463329330413795 2660 16876704
SGTC_3202 9113761 49.47 µM -0.0928375979391667 0.475930851897251 no 1766 0.463016290571884 2742 4798415
SGTC_941 3237-0776 460 µM -0.0949761621355299 0.475169326274591 no 1767 0.462166880586674 2670 760008
SGTC_572 0960-0087 17.7 µM -0.0961149630708405 0.474763845193399 no 1768 0.461714633757647 2567 6796365
SGTC_2886 9058944 51.95 µM -0.0966009433461393 0.474590815151578 no 1769 0.461521653659198 2555 4949929
SGTC_640 3381-0960 37.1 µM -0.0966767850295438 0.47456381265659 no 1770 0.461491538159299 2630 1745025
SGTC_880 0833-0487 87.2 µM -0.0967435795179968 0.474540031400428 no 1771 0.461465015336345 2571 76075
SGTC_475 α-linolenic acid 10 µM -0.0969402620382975 0.474470005829539 no 1772 0.461386917438283 2771 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2618 avocadyne 43.43 µM -0.0972479453500925 0.474360461838486 no 1773 0.461264746783629 2611 3015189
SGTC_905 2-aminofluorene 215 µM -0.0980909417084045 0.474060341166368 no 1774 0.460930040154084 2583 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2822 7994718 71.43 µM -0.0981157012661918 0.474051526575231 no 1775 0.460920209937925 2566 1018011
SGTC_2761 levamisole 97.89 µM -0.0988466586822991 0.473791305910137 no 1776 0.460630010797889 2607 26879 An alkaline phosphatase inhibitor.
SGTC_2298 7976326 193.81 µM -0.0995822072577442 0.473529462081795 no 1777 0.460338010075969 2627 2235818
SGTC_1125 tnp00248 1.32998 µM -0.100769559396898 0.473106807406086 no 1778 0.459866695943981 2704 24207736
SGTC_2782 7736369 71.43 µM -0.101074835853565 0.472998144835913 no 1779 0.459745526903512 2618 2950836 YOL077C BRX1
SGTC_1772 st048439 82.2 µM -0.101553093663259 0.472827913927209 no 1780 0.459555706356668 2645 2927068 YDL195W SEC31
SGTC_419 nsc-638432 893 µM -0.101615458906563 0.472805716030565 no 1781 0.459530954267262 2643 368090
SGTC_2479 5617353 43.85 µM -0.101774043763114 0.472749270704077 no 1782 0.459468014362584 2681 2731746
SGTC_140 0062-0056 502.533 µM -0.10386394665924 0.47200546023943 no 1783 0.458638659357369 2571 3758964
SGTC_1814 st052110 31.539 µM -0.104261830693532 0.471863861624711 no 1784 0.458480783737092 2619 674163
SGTC_708 3448-5400 146 µM -0.10582032428802 0.471309260729313 no 1785 0.457862455439752 2597 3462195
SGTC_1232 0279-0259 161 µM -0.105864327159244 0.471293602800954 no 1786 0.457844998887687 2599 1560000
SGTC_851 0394-0702 453 µM -0.105922836673342 0.471272782915112 no 1787 0.457821787474244 2593 762646
SGTC_1875 nocodazole 6 µM -0.106007313935168 0.471242722866426 no 1788 0.457788274603202 2572 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1093 fluphenazine 7.97 µM -0.10624624059068 0.471157705054948 no 1789 0.457693491927941 2615 6602611 An atypical antipsychotic.
SGTC_2402 5553605 200 µM -0.106311504997931 0.471134482101906 no 1790 0.457667601827072 2708 6758546
SGTC_230 MPP+ 141.667 µM -0.106568048966927 0.471043197331755 no 1791 0.457565833714397 2636 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_543 3844-1095 191 µM -0.107055066885081 0.470869908347043 no 1792 0.45737264683298 2693 4230703
SGTC_2949 9072542 2.23 µM -0.107414931082446 0.470741866289057 no 1793 0.457229904873695 2673 16457352
SGTC_3138 9097216 49.47 µM -0.108166666389482 0.470474403676357 no 1794 0.456931743073737 2566 25237486
SGTC_2029 5175081 200 µM -0.108894103858512 0.470215598757939 no 1795 0.456643241637309 2589 1380876
SGTC_528 3492-0019 172 µM -0.110513793739693 0.469639397042892 no 1796 0.456000955526974 2579 2869262
SGTC_992 3909-8734 162 µM -0.113019258456949 0.468748208209647 no 1797 0.455007643498743 2646 4288319
SGTC_643 k048-0106 28.4 µM -0.114147387984575 0.468346985626586 no 1798 0.454560478753763 2724 6763920
SGTC_297 0986-0032 24 µM -0.115612812347503 0.467825851207077 no 1799 0.453979704109013 2599 2847425
SGTC_2357 9067248 200 µM -0.115731494274496 0.467783647924925 no 1800 0.453932672567396 2681 9150235
SGTC_1868 st057644 42.7 µM -0.115851737240547 0.467740889906715 no 1801 0.45388502307249 2588 688665
SGTC_86 0417-1630 471.922 µM -0.116336819212419 0.467568400076968 no 1802 0.453692803099817 2605 3634867
SGTC_1682 st012968 530 nM -0.118081949026616 0.466947901643755 no 1803 0.453001362984833 2635 24207270
SGTC_3020 9089140 49.47 µM -0.119524822106143 0.466434934216624 no 1804 0.452429787899226 2664 17217859
SGTC_724 3910-0327 137 µM -0.11967650828493 0.466381010265646 no 1805 0.452369705131146 2660 2885483
SGTC_2236 dapsone 200 µM -0.119741488010693 0.466357910369907 no 1806 0.452343967049934 2637 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2711 st079103 59.1 µM -0.119751201980741 0.466354457122605 no 1807 0.452340119421629 2724 54693780
SGTC_1023 4482-3888 16 µM -0.12000830779295 0.466263058755468 no 1808 0.452238283428665 2776 3303168
SGTC_696 1560-0013 611 µM -0.120324483044779 0.466150664273983 no 1809 0.452113055170719 2765 1650269
SGTC_2090 5301565 104.445 µM -0.121039483249774 0.465896504832775 no 1810 0.451829880985245 2653 2056344
SGTC_1967 st070177 51.4 µM -0.121216843328975 0.465833461211555 no 1811 0.451759641721913 2741 5729214
SGTC_2728 chlorpromazine 9.18 µM -0.124803867773941 0.464558619718852 no 1812 0.450339412647785 2614 2726 A thorazine and dopamine antagonist.
SGTC_3051 9093778 49.47 µM -0.124819427363517 0.464553090567187 no 1813 0.450333253430935 2613 17217378
SGTC_2401 5128683 200 µM -0.1261041780109 0.464096573887095 no 1814 0.449824730150551 2670 708373
SGTC_1246 0422-0085 105 µM -0.12639805659885 0.463992155203443 no 1815 0.449708420212605 2669 264295
SGTC_1026 k007-1105 30.6 µM -0.127434073252936 0.463624065551474 no 1816 0.44929842475645 2627 7066794
SGTC_281 1672-3440 14.9 µM -0.127914849365843 0.463453259635765 no 1817 0.449108179745394 2723 6833000
SGTC_109 0132-0036 33.701 µM -0.127932977848668 0.463446819239177 no 1818 0.449101006461596 2605 67274 A color developer.
SGTC_584 0986-0246 15.4 µM -0.128997652069491 0.463068595719277 no 1819 0.448679753342013 2629 53315 YDR232W HEM1
SGTC_11 0438-0307 1.3 µM -0.129522659866824 0.462882099952431 no 1820 0.448472047994666 2731 4011476
SGTC_2749 bexarotene 57.39 µM -0.130002808410611 0.462711546444359 no 1821 0.448282102379348 2727 82146 An retinoic acid receptor inhibitor.
SGTC_3232 9132874 49.47 µM -0.130180009184179 0.462648604708363 no 1822 0.448212005170127 2645 3784940
SGTC_3356 9151811 4.48 µM -0.131381731259595 0.462221777639505 no 1823 0.447736669865467 2633 1859254 YPR165W RHO1
SGTC_2218 6965428 192.983 µM -0.131684124031721 0.462114380751063 no 1824 0.447617071670417 2642 675684
SGTC_2285 7945142 200 µM -0.133209918769673 0.461572526466769 no 1825 0.447013683357579 2739 2970608
SGTC_942 3253-1115 227 µM -0.133724560715633 0.461389778113131 no 1826 0.446810191475574 2780 46497897
SGTC_1958 st076513 41.9 µM -0.133926748143661 0.461317983979312 no 1827 0.446730249430069 2640 732122 YGL099W LSG1
SGTC_125 0133-0007 11.75 µM -0.134017878935659 0.461285625028827 no 1828 0.446694218313099 2750 26541
SGTC_1632 st005650 90 µM -0.134118152812268 0.461250019825082 no 1829 0.446654572729453 2759 2759605
SGTC_316 k060-0003 58.6 µM -0.134505414803003 0.461112513927497 no 1830 0.446501464802804 2782 6152314
SGTC_345 1362-0200 395 µM -0.134672600732359 0.461053152317579 no 1831 0.446435368625862 2668 1419823
SGTC_1640 st009078 66.4 µM -0.135539261436531 0.460745446731802 no 1832 0.446092762253652 2752 690618
SGTC_16 erodoxin 22.806 µM -0.13581531297776 0.460647440290434 no 1833 0.445983642613931 2647 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_549 1661-1316 519 µM -0.136320753404394 0.46046800022672 no 1834 0.445783859093466 2699 2857282
SGTC_48 0382-0018 55 µM -0.136918862731057 0.460255671508289 no 1835 0.445547464474245 2863 762596
SGTC_933 2914-0560 114 µM -0.137756654817741 0.459958274515322 no 1836 0.445216371054239 2810 463887
SGTC_3191 9110352 49.47 µM -0.139094196174247 0.45948352448034 no 1837 0.444687857213593 2616 17122424
SGTC_2493 resveratrol 26.09 µM -0.139146421225455 0.459464988766846 no 1838 0.444667223083106 2625 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_741 4582-0002 126 µM -0.139685232578575 0.459273759009843 no 1839 0.444454347349753 2658 2912688
SGTC_1243 0416-0003 5.65 µM -0.140148651333383 0.459109294406181 no 1840 0.444271270837343 2724 2141977
SGTC_1210 3013-0140 750 nM -0.140195917927702 0.459092520161331 no 1841 0.444252598537632 2809 905973
SGTC_215 1287-0124 461.5 µM -0.140300467925132 0.459055417106829 no 1842 0.444211297315552 2728 5560863
SGTC_3264 9137442 49.47 µM -0.141540277943841 0.458615456440859 no 1843 0.443721571553863 2861 17015726
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.143911568063245 0.457774118854545 no 1844 0.442785150393501 2770 23847180
SGTC_921 1561-0023 372 µM -0.145202908132402 0.457316028620896 no 1845 0.442275334956145 2640 24050882
SGTC_2289 7946404 165.07 µM -0.145900304601064 0.457068657601196 no 1846 0.442000045563138 2688 1246120 YPR165W RHO1
SGTC_874 0599-0792 117 µM -0.146683781489829 0.456790773146713 no 1847 0.441690810309837 2659 765305
SGTC_3178 9107506 49.47 µM -0.146771720741837 0.456759584071318 no 1848 0.441656103246938 2788 8897194
SGTC_2325 6158266 200 µM -0.148321734327815 0.45620989062804 no 1849 0.441044431776426 2752 3623240
SGTC_2650 prasterone 100 µM -0.148951183094174 0.455986688153494 no 1850 0.440796076691902 2662 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2811 7967822 32.47 µM -0.149971802581253 0.455624806126226 no 1851 0.44039343095216 2786 2232244
SGTC_1341 1486-1360 280 µM -0.150002743945502 0.455613835790561 no 1852 0.440381225200194 2657 3976547
SGTC_317 4495-0002 170 µM -0.151524621384812 0.455074292390521 no 1853 0.439780945005372 2719 15991618
SGTC_1306 1185-0270 9.02 µM -0.153017396244688 0.454545147071374 no 1854 0.439192278313644 2764 1548076
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.153286934911296 0.454449612013857 no 1855 0.43908600167146 3049 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_531 3788-1495 174 µM -0.15451129254666 0.454015684977276 no 1856 0.43860330398808 2640 2896655
SGTC_3080 9117754 49.47 µM -0.154886563323923 0.45388269547608 no 1857 0.438455373362169 2853 9550191
SGTC_2945 9067681 61.76 µM -0.156441403630498 0.453331742104053 no 1858 0.4378425517699 2631 16456930
SGTC_978 1416-0512 87.4 µM -0.156651050079721 0.453257461311498 no 1859 0.437759933516529 2723 6814003
SGTC_2175 5807670 165.306 µM -0.156703279752454 0.453238955831571 no 1860 0.437739351074654 2722 241186
SGTC_1413 3910-0535 34.4 µM -0.15713836953206 0.453084803250244 no 1861 0.437567899341751 2799 2876951
SGTC_2529 gangaleoidin 93.61 µM -0.159205604513066 0.452352477587563 no 1862 0.436753444209872 2703 4565183
SGTC_2591 skatole 100 µM -0.160466596577549 0.451905845891003 no 1863 0.436256766345553 2817 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2368 9071271 200 µM -0.161211666227969 0.451641977697632 no 1864 0.435963346490513 2716 27209959
SGTC_158 k038-0087 26.446 µM -0.161586769193724 0.451509142165491 no 1865 0.43581563851724 2685 X158
SGTC_1709 st033179 39.1045 µM -0.161748208947791 0.451451973038495 no 1866 0.435752069556632 2696 573381
SGTC_1239 0337-0584 35.4 µM -0.164853698043534 0.450352453036469 no 1867 0.43452956863445 2851 914301 YML130C ERO1
SGTC_3120 9124077 49.47 µM -0.168473531794721 0.449071307100971 no 1868 0.433105382302637 2674 18774327 YGL155W CDC43
SGTC_1087 pterostilbene 9.05 µM -0.16852309320664 0.449053769782409 no 1869 0.433085888859269 2826 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2515 chrysin 20.77 µM -0.169109997668563 0.448846101062572 no 1870 0.432855060594862 2814 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_641 4092-0595 30 µM -0.169365484248824 0.448755704742581 no 1871 0.432754585423837 2751 786260
SGTC_2801 7907800 81.82 µM -0.172134949090477 0.447775983750456 no 1872 0.431665718711556 2798 6620925
SGTC_113 0099-0221 2.5 µM -0.172199817678858 0.447753039747523 no 1873 0.431640220605708 2761 89219
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.172465991529196 0.447658895956609 no 1874 0.431535597772667 2788 688761
SGTC_815 1582-0027 36.9 µM -0.172663534131297 0.447589028454161 no 1875 0.431457954381576 2801 3128206
SGTC_2544 sphondin 68.51 µM -0.17334623992503 0.447347579409642 no 1876 0.43118963979748 2942 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_534 k292-0788 63.4 µM -0.173521604605131 0.447285562231796 no 1877 0.431120723720079 2712 4146317
SGTC_465 cgp-37157 41 µM -0.173677990649925 0.447230257876887 no 1878 0.431059267772574 2788 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1819 st053448 58.6 µM -0.175176128619287 0.446700508572401 no 1879 0.430470620445483 2737 2857616
SGTC_3074 9116018 49.47 µM -0.175448291540198 0.446604280541203 no 1880 0.430363698922081 2678 17027303
SGTC_2971 9092186 9.93 µM -0.176237693202849 0.446325191377425 no 1881 0.43005360465702 2689 25236400
SGTC_986 1493-0483 84 µM -0.176602260464928 0.44619630934038 no 1882 0.429910409200731 2717 40079
SGTC_379 3970-0972 5.9 µM -0.176803680621152 0.446125105602834 no 1883 0.429831298942669 2781 2898042 YBL034C STU1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.176887741149919 0.446095390004978 no 1884 0.429798283963137 2734 77254
SGTC_3275 9138069 49.47 µM -0.177123041016498 0.446012212550027 no 1885 0.4297058719725 2802 17617007
SGTC_2393 9031399 185.94 µM -0.179561573547985 0.44515034271743 no 1886 0.42874838706985 2864 1526623 YDL150W RPC53
SGTC_2674 ligustilide 100 µM -0.180223886196858 0.44491630091069 no 1887 0.428488403489716 2808 5319022 A signalling regulator.
SGTC_209 4077-0173 175.592 µM -0.180716702345062 0.44474216663525 no 1888 0.428294974034513 2822 15993494
SGTC_1571 st070080 73.4 µM -0.180721069457387 0.444740623584203 no 1889 0.428293260027684 2860 4315245
SGTC_3133 9127736 49.47 µM -0.180932593184725 0.44466588597625 no 1890 0.428210242690168 2700 27243420
SGTC_2895 9054447 58.44 µM -0.182367948329088 0.444158784521652 no 1891 0.427646988759247 2740 2697450
SGTC_506 n9-isopropylolomoucine 153 µM -0.182489128042998 0.444115976704861 no 1892 0.427599442835339 2816 6610355
SGTC_2763 lisinopril 49.32 µM -0.188223469793641 0.442091023323529 no 1893 0.425350737528519 2734 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1877 wortmannin 25 µM -0.18935023184629 0.441693308839578 no 1894 0.424909164005339 2859 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2225 6654152 15.4 µM -0.191443610942178 0.440954562776376 no 1895 0.424089027637535 2736 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2442 5158906 48.48 µM -0.191793841291645 0.440830987716549 no 1896 0.423951847673059 2898 1893835
SGTC_1565 sinapyl alcohol 95.1 µM -0.191943438896686 0.440778205545499 no 1897 0.423893255346923 2809 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1174 0739-0097 51.1 µM -0.192342064116715 0.440637564686234 no 1898 0.423737135537869 2810 728447
SGTC_2000 st075254 36.4 µM -0.192567151916006 0.440558153696086 no 1899 0.423648986180215 2757 17234175
SGTC_958 1222-0007 33 µM -0.196760398283552 0.439079216572489 no 1900 0.422007521415254 2925 7312461
SGTC_2663 amphotericin b 100 µM -0.197078935614034 0.438966904521524 no 1901 0.421882883549284 2758 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2767 sibutramine 71.45 µM -0.19803008012418 0.438631572819835 no 1902 0.421510764605035 2908 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2272 7805186 180 µM -0.20082933444083 0.437644935385303 no 1903 0.420416012318378 2806 2956062 YPR165W RHO1
SGTC_111 0083-0039 52.457 µM -0.200895014998596 0.437621789958037 no 1904 0.420390332854096 2738 759313
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.206094221005908 0.435790305127069 no 1905 0.418358656423016 2763 23665772 A membrane-active detergent.
SGTC_1254 0550-0035 264 µM -0.206345025915806 0.435701990466172 no 1906 0.418260704812816 2910 15121435
SGTC_2418 pentamidine 31.67 µM -0.207025599980699 0.435462359539995 no 1907 0.41799493284052 2731 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_313 3474-0040 5.03 µM -0.207923478624446 0.435146251683961 no 1908 0.417644358244599 2773 1043375 YIL048W NEO1
SGTC_773 4358-1457 44.6 µM -0.210812830778792 0.434129306360537 no 1909 0.416516663013873 2893 1186886
SGTC_689 0833-0039 98 µM -0.21198220822293 0.433717852152687 no 1910 0.41606045734143 2832 5374726
SGTC_1450 4112-4260 37.6 µM -0.212166954791166 0.433652854247426 no 1911 0.415988393051532 2894 1633175
SGTC_2135 5326629 150.42 µM -0.213836608554874 0.433065514926858 no 1912 0.415337237840493 2834 5020077
SGTC_3021 9087658 49.47 µM -0.213879612833201 0.433050389124705 no 1913 0.415320469486356 2803 25237042
SGTC_2564 betulinic acid 100 µM -0.214607171042327 0.43279450152759 no 1914 0.415036801259876 3065 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2035 5154463 94.595 µM -0.21520788172377 0.4325832483764 no 1915 0.414802623085783 2911 2769623
SGTC_3091 9116372 49.47 µM -0.21565086701482 0.432427475175937 no 1916 0.414629951210689 2946 17169793
SGTC_487 nimodipine 119 µM -0.215983388282769 0.432310552905836 no 1917 0.414500348102326 2870 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1766 st045414 44.774 µM -0.218404808035911 0.43145930435887 no 1918 0.413556859845952 2779 253960
SGTC_2683 piperine 63.03 µM -0.218841757219972 0.43130572893443 no 1919 0.413386658811483 2815 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_742 0kpi-0133 140 µM -0.219244963568247 0.431164022385521 no 1920 0.413229615768823 2958 2728852
SGTC_652 0437-0092 114 µM -0.221552969051237 0.43035304676046 no 1921 0.412330948901435 2805 3091274
SGTC_2030 5175110 200 µM -0.221828419517696 0.430256279878642 no 1922 0.41222372749676 2933 2831986
SGTC_1767 st044992 70.3 µM -0.222573781194083 0.429994452273751 no 1923 0.411933622083037 2863 9600693
SGTC_2600 tangeritin 87.95 µM -0.222960827230804 0.429858504458111 no 1924 0.41178299720887 2789 68077 A bioactive flavone.
SGTC_644 1498-1197 63.3 µM -0.223408918328099 0.429701125284712 no 1925 0.411608631953288 2914 6741615
SGTC_2179 6298986 200 µM -0.223550280150806 0.42965147830703 no 1926 0.411553627584072 2932 738374
SGTC_1391 3442-0225 151 µM -0.223769341764443 0.429574544973047 no 1927 0.411468393394411 2807 5227075
SGTC_602 3130-1533 38.1 µM -0.226480988555484 0.428622450644549 no 1928 0.410413672023909 2926 720941
SGTC_2702 st077768 96.8 µM -0.226569323144276 0.428591442179698 no 1929 0.410379324278066 2889 6484119
SGTC_2373 9071805 200 µM -0.226724732171996 0.428536889360543 no 1930 0.410318897185429 2923 10149009
SGTC_122 0236-0016 402.397 µM -0.228027924999513 0.428079486866787 no 1931 0.409812265664684 2844 6808838
SGTC_319 1348-1596 45.5 µM -0.229423589989219 0.427589735092504 no 1932 0.409269851457423 3015 5380505
SGTC_3308 9128332 17.569 µM -0.230728993981444 0.427131757686662 no 1933 0.408762673626247 2973 17332805 YDL196W YDL196W
SGTC_2794 7785382 27.27 µM -0.234783690459097 0.425709869545252 no 1934 0.407188313540667 2821 2205081
SGTC_2607 solasodine 47.35 µM -0.235051485439869 0.425615993835582 no 1935 0.407084386406763 2849 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2616 abietic acid 100 µM -0.235266990851755 0.425540451330738 no 1936 0.407000756804313 2924 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1908 st060353 56.5 µM -0.235400537208547 0.425493639834651 no 1937 0.406948934578069 3036 4227716
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.235581324708081 0.425430270753941 no 1938 0.406878783176774 2836 641818 YHR062C RPP1
SGTC_1035 k081-0041 55.2 µM -0.235742694174715 0.425373709649633 no 1939 0.406816169124249 2920 731709
SGTC_636 0kpi-0074 126 µM -0.235930352597531 0.425307936017545 no 1940 0.406743357512621 2909 616434
SGTC_1799 st045822 46.1415 µM -0.236195031680346 0.425215170442967 no 1941 0.406640667306276 2969 3674992
SGTC_3136 9095672 49.47 µM -0.236948439525043 0.424951136326367 no 1942 0.406348395252647 2724 17217380
SGTC_1631 benzylvanillin 81.9 µM -0.237181569595328 0.424869441984394 no 1943 0.406257966878104 2967 75506
SGTC_2434 5670830 169.91 µM -0.237753257228316 0.424669122655055 no 1944 0.406036237235465 2923 1549830
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.238497717704736 0.424408292894844 no 1945 0.405747542649188 2798 6312947
SGTC_2421 5690543 90.72 µM -0.238614098210134 0.424367520717968 no 1946 0.405702416041316 2916 3397993
SGTC_1105 epirubicin 18.1 µM -0.239880606063309 0.423923870972134 no 1947 0.40521140803876 2816 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_912 3474-0017 2.18 µM -0.240647546747481 0.423655263294121 no 1948 0.404914147944438 2999 3360550
SGTC_2551 apiole 73.87 µM -0.24067751091199 0.423644769584188 no 1949 0.404902535185621 2811 10659 A possible DNA adduct former.
SGTC_2104 5389443 200 µM -0.241127355480948 0.423487236632883 no 1950 0.404728205789897 3019 2244536
SGTC_2979 9012552 45.46 µM -0.241319267032912 0.42342003404378 no 1951 0.404653839576221 2935 17100905
SGTC_718 1130-0073 349 µM -0.243059562994339 0.422810728182736 no 1952 0.403979628007287 2999 6740020
SGTC_973 1325-0077 65.9 µM -0.243919858992675 0.422509592687862 no 1953 0.403646444193099 2887 2835149
SGTC_1322 1348-1070 12 µM -0.246095968864803 0.421748076085849 no 1954 0.402803971759614 2840 6758089
SGTC_2023 5144124 124 µM -0.246097058807135 0.421747694740125 no 1955 0.402803549905401 2848 2830192
SGTC_2984 9022109 38.96 µM -0.246546438330536 0.421590473449155 no 1956 0.402629630491855 2923 6459207
SGTC_1612 st002233 45.4 µM -0.247458222731608 0.421271512209387 no 1957 0.402276809819185 2847 1035021
SGTC_2941 9056145 11.23 µM -0.248336042338013 0.420964481369267 no 1958 0.401937207237905 2822 2119517
SGTC_2757 clomiphene 4.22 µM -0.248896750145455 0.4207683903767 no 1959 0.401720324609181 3064 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2909 7941780 10.49 µM -0.251903589186543 0.419717173761668 no 1960 0.400557792631573 2955 1243215
SGTC_1790 st045711 43.5 µM -0.253245061478269 0.419248367860793 no 1961 0.40003942354201 3013 585119
SGTC_501 nsc-95397 161 µM -0.254345498395355 0.418863882419087 no 1962 0.399614326288385 3020 262093
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.254747720182756 0.418723368081717 no 1963 0.399458978232899 2796 6708630 An antioxidant.
SGTC_2235 salicylic acid 500 µM -0.255768096858586 0.418366950725429 no 1964 0.399064954850216 2854 338 A COX inhibitor and kinase inhibitor.
SGTC_1550 gossypolone 36.6 µM -0.256338347951596 0.418167791312691 no 1965 0.398844794398685 2853 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2652 actinonin 100 µM -0.256603772835716 0.418075099187897 no 1966 0.39874233110337 2839 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1771 st048882 4.1505 µM -0.258872579925863 0.417282968750676 no 1967 0.397866777615293 2845 4580403
SGTC_2871 9038510 12.99 µM -0.259202150223913 0.417167930543783 no 1968 0.397739636074137 3047 4945164
SGTC_2879 9041815 71.43 µM -0.259586271717021 0.417033859910841 no 1969 0.397591463494424 2979 4942971
SGTC_603 3794-0023 45.9 µM -0.259683198969039 0.417000030737107 no 1970 0.397554076717397 2968 3802260
SGTC_1176 0848-0131 83.3 µM -0.259708407357133 0.416991232703907 no 1971 0.397544353492804 2959 6769040
SGTC_216 k038-0035 28.382 µM -0.260355666538804 0.416765345647656 no 1972 0.397294718474438 2947 4444231 YPR107C YTH1
SGTC_1782 st039423 80.636 µM -0.261919287587963 0.416219770870323 no 1973 0.396691834613117 2913 2068169
SGTC_1606 st000094 49.2 µM -0.262563584063539 0.41599501143356 no 1974 0.396443485579253 3001 1242210
SGTC_1638 st008370 60.6 µM -0.26294902463242 0.415860565647029 no 1975 0.396294934623156 2827 24207134
SGTC_1221 2958-7315 257 µM -0.26345804037707 0.41568303061071 no 1976 0.396098780173851 2958 4562705
SGTC_3079 9117512 49.47 µM -0.263788608292368 0.415567744006773 no 1977 0.395971406514694 2852 7185044
SGTC_2198 6589944 200 µM -0.264249147248094 0.415407141709355 no 1978 0.395793971234962 2897 5290268
SGTC_2929 9013348 24.6 µM -0.264308436916984 0.415386466836327 no 1979 0.395771129829916 2981 2995952
SGTC_387 norethindrone acetate 66.7 µM -0.264714738700318 0.415244791835683 no 1980 0.395614611290992 2921 541197
SGTC_43 0570-0105 72.5 µM -0.264900030921462 0.415180185204401 no 1981 0.395543237256362 2877 1114046 YDL195W SEC31
SGTC_1761 st044296 37 µM -0.265181137447148 0.415082174969331 no 1982 0.395434962514764 2856 1826700
SGTC_2158 5657123 3.6195 µM -0.266618024105251 0.414581274608297 no 1983 0.394881638306023 2846 2858827
SGTC_964 1287-0107 19.4 µM -0.269301243165653 0.413646273701802 no 1984 0.393848937800315 3040 51516812 YPR165W RHO1
SGTC_515 4092-1064 102 µM -0.26990115457548 0.413437293897516 no 1985 0.393618149453329 3128 717353
SGTC_2228 7354201 200 µM -0.271722903483242 0.412802836166445 no 1986 0.39291754461402 2907 753451
SGTC_486 niguldipine 82 µM -0.272377330290142 0.412574975442777 no 1987 0.392665950893642 2871 1236 A calcium channel blocker.
SGTC_772 k072-0172 35.3 µM -0.272755574283729 0.412443290492156 no 1988 0.392520555817707 2913 5861980
SGTC_3196 9111891 49.47 µM -0.272965427120976 0.412370234862672 no 1989 0.392439895917783 2848 18891510
SGTC_3235 9132602 49.47 µM -0.274165406990287 0.411952546769799 no 1990 0.391978755563574 2990 4912240
SGTC_3182 9108849 49.47 µM -0.27438898401447 0.411874735254853 no 1991 0.39189285387753 2988 17133045
SGTC_2342 7990637 118.86 µM -0.275007188536864 0.411659599571339 no 1992 0.391655357759581 3008 2033102 YER133W GLC7
SGTC_1489 4065-0444 182 µM -0.275609686523063 0.411449955325609 no 1993 0.391423934481162 3020 2877968
SGTC_2958 9077254 16.72 µM -0.275678000278504 0.411426186573968 no 1994 0.391397697160601 3087 16457351
SGTC_480 am 92016 50 µM -0.277870034906429 0.410663673875161 no 1995 0.390556063532214 2959 2129 K+ channel blocker.
SGTC_2617 dihydrotanshinone i 20.83 µM -0.278051315221135 0.410600629476378 no 1996 0.390486483688026 2904 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_739 1486-1183 203 µM -0.278213105055011 0.410544365291134 no 1997 0.390424387731541 3025 4346692
SGTC_1249 0481-0015 10.2 µM -0.278547538218643 0.410428068335542 no 1998 0.390296039040284 2864 4227577
SGTC_232 clozapine 119 µM -0.27856747773372 0.410421134747658 no 1999 0.390288387034792 2880 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1376 2910-0861 41.3 µM -0.280362504563831 0.409797063208097 no 2000 0.389599700472724 2874 1112859
SGTC_2354 9060492 162 µM -0.280749329053102 0.409662606975127 no 2001 0.389451335284296 3041 6471895
SGTC_1451 4152-0210 104 µM -0.281146014056824 0.409524734361549 no 2002 0.38929920486298 3072 659563
SGTC_2186 6124449 200 µM -0.28230506001622 0.409121958251398 no 2003 0.388854802989698 3061 3834182 YLR033W RSC58
SGTC_1478 0453-0656 35.7 µM -0.282547622988789 0.409037678144378 no 2004 0.388761817774634 2953 5258496
SGTC_824 1304-0008 100 µM -0.283292953425366 0.40877873448938 no 2005 0.388476139244011 2920 768245
SGTC_105 0111-0055 734.78 µM -0.283872298206011 0.408577485278003 no 2006 0.388254123193797 2996 5179370
SGTC_3302 9125395 16.351 µM -0.284750168685268 0.408272582007131 no 2007 0.387917775958952 2948 17599668
SGTC_2143 5623677 140.463 µM -0.286944053019586 0.407510842023444 no 2008 0.387077579354308 2906 5375313
SGTC_2864 9034755 47.6 µM -0.287151149784187 0.4074389538361 no 2009 0.386998294315247 2886 4930451
SGTC_2064 5220758 200 µM -0.287757730065005 0.407228413412276 no 2010 0.386766097927564 3078 788518
SGTC_1064 honokiol 6.76 µM -0.289265468850028 0.406705202432967 no 2011 0.386189117570604 2988 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3244 9134489 49.47 µM -0.289792980038522 0.406522186353509 no 2012 0.385987309329349 2985 16584271
SGTC_425 3825-7017 13.1 µM -0.289818120277565 0.406513464644152 no 2013 0.385977692279493 3156 3397440
SGTC_2018 5133068 143 µM -0.290201617356323 0.406380426710647 no 2014 0.385830999479721 2874 785362
SGTC_361 000s-0510 1.45 µM -0.29090196461634 0.406137499036943 no 2015 0.385563149358678 3007 660
SGTC_2164 5685496 200 µM -0.29314574379085 0.405359448811042 no 2016 0.384705376643287 3022 759046
SGTC_896 0964-0007 44.5 µM -0.293196845616945 0.405341733144497 no 2017 0.384685847517234 3023 6756758
SGTC_3014 9081533 49.47 µM -0.293350187566119 0.405288574665568 no 2018 0.384627247957842 3074 21367265
SGTC_1496 4469-0713 57.4 µM -0.294447116682555 0.40490835736738 no 2019 0.384208133917942 3033 746691
SGTC_1667 st014849 34.6 µM -0.294992868446374 0.404719222439622 no 2020 0.383999663792902 2894 5348460
SGTC_705 1124-0212 310 µM -0.295057475751388 0.404696833699775 no 2021 0.38397498685731 3067 9554485
SGTC_867 0518-0118 155 µM -0.295243230145613 0.40463246490286 no 2022 0.383904040082877 3016 6848158
SGTC_271 rotenone 740 µM -0.29678387276871 0.40409869122772 no 2023 0.383315759355586 3048 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_627 1391-0720 175 µM -0.297341026511728 0.40390570268653 no 2024 0.383103081282779 3015 997839
SGTC_1511 0906-3109 28.5 µM -0.297539942947937 0.403836807093619 no 2025 0.383027158951391 2918 2882180
SGTC_300 r073-0011 5.04 µM -0.298971010708025 0.40334123846672 no 2026 0.382481082299306 3021 2735780
SGTC_1331 1472-0049 76.2 µM -0.299573596657166 0.403132613603247 no 2027 0.38225121324757 2915 24051409
SGTC_2876 9059903 25.97 µM -0.299625487379685 0.403114649496205 no 2028 0.382231420382134 2900 6916095
SGTC_3029 9088683 49.47 µM -0.299855106955055 0.403035159694457 no 2029 0.382143839453787 3075 25236615
SGTC_325 2810-4341 181 µM -0.300094128608898 0.402952419333797 no 2030 0.382052678813451 3042 774970
SGTC_1161 k007-0610 110 µM -0.301293414227083 0.402537337161042 no 2031 0.381595381214333 3031 5843850
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.301946664346292 0.402311288347229 no 2032 0.381346360965576 3092 5282362
SGTC_1583 clindamycin 39.6 µM -0.30670740247653 0.400664887073521 no 2033 0.379533047412583 2937 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1668 st014914 51.6 µM -0.310216709610123 0.399452393987725 no 2034 0.378198082241239 3014 2839556
SGTC_2006 4011487 200 µM -0.310792565249847 0.399253523611202 no 2035 0.377979161031285 3116 45595294
SGTC_3243 9134147 49.47 µM -0.311400655859696 0.399043549343465 no 2036 0.377748027684554 3014 24282180
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.311466286922504 0.399020888620202 no 2037 0.377723084137207 3079 521171
SGTC_2072 5231554 129 µM -0.313876878814328 0.398188809452488 no 2038 0.376807275818636 3066 789545
SGTC_3008 9078912 71.4286 µM -0.314904796013311 0.397834137321623 no 2039 0.376416970022387 2985 16648731
SGTC_1217 1183-1422 255 µM -0.315958392533371 0.397470692417477 no 2040 0.376017044743317 3102 2849664
SGTC_2859 9028643 45.46 µM -0.31632996767894 0.397342536388846 no 2041 0.375876033586994 3027 17151580
SGTC_1 0258-0098 57.368 µM -0.319145133669578 0.39637194840632 no 2042 0.374808229995324 3019 6790032 YDR047W HEM12
SGTC_1360 1598-0022 39.8 µM -0.321208352289488 0.395661017408263 no 2043 0.37402625152115 3086 761525
SGTC_2159 5658611 73.75 µM -0.321843149874759 0.395442352516041 no 2044 0.37378576158764 3085 793844
SGTC_1547 harmine 94.2 µM -0.32271408084634 0.395142401748841 no 2045 0.373455893642771 3000 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2747 doxorubicin 7.63 µM -0.323126197152107 0.395000489522356 no 2046 0.373299835545327 3000 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2476 5806916 10.51 µM -0.327157335857465 0.393613104300516 no 2047 0.371774443935636 2963 2870194
SGTC_3121 9125696 49.47 µM -0.329015148131864 0.392974159687175 no 2048 0.371072119170633 2999 1235365
SGTC_2280 7785178 200 µM -0.329452185160787 0.392823894359572 no 2049 0.370906964574425 2984 2954328
SGTC_1076 itraconazole 331 nM -0.329817917309697 0.392698157881327 no 2050 0.37076877408932 3007 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2965 9082772 38.63 µM -0.33322057716275 0.391528882561965 no 2051 0.369483893268953 3192 16459634
SGTC_1679 SEC14.276 6.7 µM -0.333406642087607 0.391464972162129 no 2052 0.3694136750255 3108 1005053 YMR079W SEC14
SGTC_2964 9083345 53.42 µM -0.334139282249542 0.391213350187534 no 2053 0.369137229462781 3047 17741579
SGTC_3170 9103054 49.47 µM -0.337568550173743 0.390036190354108 no 2054 0.367844172813937 3057 16432970
SGTC_606 k015-0008 38.6 µM -0.338875722274505 0.389587743958105 no 2055 0.367351677139276 3149 1970475
SGTC_260 nsc-65238 3.989 µM -0.340131297600505 0.389157137034335 no 2056 0.366878826641743 3135 3246252
SGTC_1619 st003326 88.7 µM -0.340228285710647 0.389123880048836 no 2057 0.366842309246967 3151 2849032
SGTC_2034 5197015 53.07 µM -0.341069770383822 0.388835371135463 no 2058 0.366525528982869 3154 780676
SGTC_854 0422-0053 192 µM -0.341591210093753 0.388656622628975 no 2059 0.366329276528327 3027 3596728
SGTC_3198 9112019 49.47 µM -0.342665739862951 0.388288350315358 no 2060 0.365924969767631 2986 45595555
SGTC_3062 9077494 49.47 µM -0.343252417738827 0.388087321260655 no 2061 0.365704286853167 3127 16459633
SGTC_2352 9027995 87.8 µM -0.344105643660746 0.387795011280713 no 2062 0.365383419383721 3055 2997347
SGTC_1781 st038725 66.3 µM -0.346780903356106 0.38687889657169 no 2063 0.364377962413828 3011 4270275 YIL048W NEO1
SGTC_1616 st002734 56.1 µM -0.347485267895751 0.38663779884595 no 2064 0.364113392168674 3004 4026101
SGTC_2723 salbutamol 83.58 µM -0.347574926868873 0.386607112512708 no 2065 0.364079719510838 3116 9884233 β2-adrenoceptor agonist
SGTC_771 0250-0039 27.3 µM -0.347816496035809 0.386524437513436 no 2066 0.363989000117897 3026 3005115
SGTC_804 1595-0054 20.9 µM -0.34895419089828 0.386135140399809 no 2067 0.363561850352888 3022 761523 Stimulates phospholipase C.
SGTC_1899 st063254 59.6 µM -0.349335506309717 0.386004687288114 no 2068 0.363418722646555 2984 3093813
SGTC_2656 pseudo-anisatin 100 µM -0.349805446890287 0.385843932050074 no 2069 0.363242355485918 3033 6708809 A neurotoxin.
SGTC_3241 9133421 49.47 µM -0.350629216086961 0.385562187963743 no 2070 0.362933267573728 3074 17018221
SGTC_1832 st054113 55 µM -0.350836813153294 0.385491195500259 no 2071 0.362855388782355 3151 1251267
SGTC_793 0488-0545 106 µM -0.35113838894163 0.38538807174437 no 2072 0.362742264543805 3001 292548
SGTC_541 4513-1321 94 µM -0.35115127662488 0.385383664985197 no 2073 0.362737430505587 3024 747515
SGTC_2153 5569715 200 µM -0.351482968081563 0.385270252923261 no 2074 0.362613023960518 3062 2054701
SGTC_3312 9133330 71.43 µM -0.353283121734022 0.384654915094395 no 2075 0.361938098844094 3170 17617324
SGTC_3073 9114972 49.47 µM -0.353583116888933 0.384552397394864 no 2076 0.361825664403351 3127 41905075
SGTC_1203 3992-3522 103 µM -0.355136982735304 0.384021522332659 no 2077 0.361243485930196 3340 5322312
SGTC_82 0054-0107 293.755 µM -0.356157680425717 0.383672921387353 no 2078 0.360861241375501 3091 3104697
SGTC_2916 7875993 68.79 µM -0.356831255889675 0.383442925333825 no 2079 0.360609067877587 3138 1299250
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.357703116623569 0.383145284673087 no 2080 0.360282750251463 3096 1241132 A phosphatase inhibitor.
SGTC_1628 st004252 77.7 µM -0.35773137696706 0.383135638153141 no 2081 0.360272174749568 3172 692968
SGTC_397 arbidol 50 µM -0.358970003112878 0.382712910890335 no 2082 0.359808764884601 3178 131410 A RNA synthesis inhibitor.
SGTC_143 4032-1194 15.74 µM -0.359193573740226 0.382636623962435 no 2083 0.359725141853837 2972 1806963
SGTC_1100 amiodarone 5.07 µM -0.359662508871158 0.382476628380281 no 2084 0.35954976595815 3132 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1395 3486-0190 4.35 µM -0.360193499522981 0.3822954843449 no 2085 0.359351217778622 3210 6748079
SGTC_803 4488-1585 147 µM -0.36110692854117 0.381983934211572 no 2086 0.35900975700148 3165 747204
SGTC_512 prima-1 270 µM -0.362822679911603 0.381398936637281 no 2087 0.35836867429172 3182 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2759 disulfiram 3.38 µM -0.363221797952016 0.381262893299312 no 2088 0.358219602784981 3011 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2383 9036125 200 µM -0.364841016704383 0.380711117210898 no 2089 0.35761504273732 3045 79580
SGTC_897 1000-0139 31.4 µM -0.366181028499266 0.380254668959061 no 2090 0.357114998812998 3195 6151020
SGTC_1212 0520-0165 585 µM -0.366743154317453 0.380063241623695 no 2091 0.356905306784407 3437 5403258
SGTC_136 0097-0015 404.482 µM -0.367002870265096 0.379974807408192 no 2092 0.356808438507507 3140 4861337
SGTC_2481 5478948 45.16 µM -0.371678442882323 0.378383835703973 no 2093 0.35506613854124 3197 77792
SGTC_299 1273-0059 1.44 µM -0.372400196984793 0.378138425005858 no 2094 0.354797453639803 3162 2848077
SGTC_3325 9138760 55.175 µM -0.373139526980219 0.377887089124647 no 2095 0.35452230068931 3073 43844959
SGTC_749 1000-0129 128 µM -0.373776311150654 0.377670655208358 no 2096 0.354285372565557 3241 708470
SGTC_130 0136-0219 337.655 µM -0.374013236421079 0.3775901374648 no 2097 0.354197234228638 3012 234244
SGTC_3324 9138759 60.749 µM -0.374141017192505 0.377546714083791 no 2098 0.354149701871116 3187 45595710
SGTC_1864 st057645 30.4 µM -0.374477601335187 0.377432341048336 no 2099 0.354024508951609 3145 688666
SGTC_3032 9089427 49.47 µM -0.374536037048702 0.377412485384899 no 2100 0.354002775317413 3151 17173707
SGTC_2818 7996756 12.99 µM -0.374808665007805 0.377319854382534 no 2101 0.353901384770875 2979 2241621
SGTC_12 0849-0099 9.267 µM -0.375281383353387 0.377159255253637 no 2102 0.353725605015592 3127 6071388
SGTC_523 1934-0222 13.7 µM -0.37548453977507 0.377090242362825 no 2103 0.353650071119234 3065 1361595
SGTC_1444 4112-3581 28 µM -0.380418623486684 0.375415328687729 no 2104 0.351817346206833 3098 2877249
SGTC_3256 9138902 49.47 µM -0.380446079663708 0.375406015005634 no 2105 0.351807157415262 3082 17228773
SGTC_2712 st079126 47.7 µM -0.382169505449277 0.37482154020833 no 2106 0.351167819668819 3057 3152970
SGTC_1579 chlormadinone acetate 49.4 µM -0.383893008288272 0.374237326681602 no 2107 0.350528874321353 3202 45114258 A steroidal progestin.
SGTC_1924 st058459 75.1 µM -0.383990905569796 0.374204151218673 no 2108 0.350492594034401 3151 688683
SGTC_550 4123-0385 25.7 µM -0.385713157909407 0.373620666333428 no 2109 0.349854558466228 3080 5731123
SGTC_2387 9077560 195.08 µM -0.387193797591824 0.37311926924314 no 2110 0.349306370772512 3082 5303272
SGTC_2594 a-mangostin 100 µM -0.387731209758984 0.372937335517773 no 2111 0.349107478527165 3217 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1253 0550-0034 176 µM -0.387820225610555 0.372907203122124 no 2112 0.349074538421771 3196 5969915
SGTC_3108 9121785 49.47 µM -0.38831880254224 0.372738446241491 no 2113 0.348890062234667 3125 17140271
SGTC_2888 9058547 12.99 µM -0.393419108375153 0.371013517540692 no 2114 0.347004979363328 3085 16476514
SGTC_536 3852-0578 10.6 µM -0.394415435526082 0.370676859802187 no 2115 0.346637174810101 3244 2869208
SGTC_969 1313-0238 134 µM -0.394435288761415 0.370670152423112 no 2116 0.346629847248747 3087 5212874
SGTC_2 0422-0095 29 µM -0.399146098807591 0.369079729301672 no 2117 0.344892778374131 3153 6790840
SGTC_2083 5306046 65.942 µM -0.402326151805671 0.368007371077872 no 2118 0.343722005326906 3143 539837
SGTC_2346 9031566 143.75 µM -0.402586027952369 0.367919782533686 no 2119 0.343626394967999 3160 4771086
SGTC_114 0364-0001 490.298 µM -0.402610212177659 0.36791163184204 no 2120 0.343617497921063 3171 4003655
SGTC_554 4483-2211 187 µM -0.405640265185014 0.366890899469852 no 2121 0.342503469497556 3191 747107
SGTC_1122 capsaicin 818.572 nM -0.405718029387708 0.366864715430116 no 2122 0.342474896706966 3228 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2787 5284540 71.43 µM -0.408920201575695 0.365787048959423 no 2123 0.341299111638598 3149 736958
SGTC_167 3672-0051 66.205 µM -0.409126430206906 0.365717680479259 no 2124 0.341223440498868 3072 3237971
SGTC_2546 rhodinyl acetate 100 µM -0.409893111246776 0.365459832893441 no 2125 0.340942179465928 3249 6708682
SGTC_2762 leflunomide 42.06 µM -0.410962578590665 0.365100254803063 no 2126 0.340549987310037 3120 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_39 0986-0283 58.349 µM -0.411824464023021 0.364810556521849 no 2127 0.340234044416967 3306 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3297 9117502 71.43 µM -0.413570176049506 0.364224021649768 no 2128 0.339594459363596 3223 7453720
SGTC_1440 4100-1550 40 µM -0.414279690864097 0.363985725342453 no 2129 0.339334642788707 3168 742806
SGTC_509 pifithrin 175 µM -0.416193438701275 0.363343240042384 no 2130 0.338634230283268 3250 4817 A p53 inhibitor.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.417246761473878 0.362989781317099 no 2131 0.338248962513071 3249 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2883 9059145 45.46 µM -0.417372304411796 0.362947661221325 no 2132 0.338203054683658 3083 16476510
SGTC_2327 6189656 200 µM -0.419718985862399 0.362160646992761 no 2133 0.337345376879407 3238 5349088
SGTC_1739 st037196 92.5 µM -0.42053777301227 0.361886184542628 no 2134 0.337046320631438 3295 612214
SGTC_1312 1218-2183 165 µM -0.420923673674348 0.361756852900293 no 2135 0.336905408815602 3226 6744073
SGTC_2145 5634607 200 µM -0.421523713603137 0.3615557854937 no 2136 0.336686349409144 3131 308662
SGTC_3167 9103034 49.47 µM -0.423368696036552 0.360937789913735 no 2137 0.336013140303904 3219 5127859
SGTC_2133 5320837 200 µM -0.423925857497665 0.36075123429466 no 2138 0.335809942883071 3276 2841355
SGTC_272 doxorubicin 8.13 µM -0.424012821069394 0.360722119075335 no 2139 0.33577823149754 3220 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_594 1487-1584 10.8 µM -0.424063532260696 0.360705141448681 no 2140 0.335759740131898 3150 5013332
SGTC_829 1635-0120 117 µM -0.424263146325993 0.360638315217289 no 2141 0.335686956577756 3271 285054
SGTC_709 3807-1509 243 µM -0.424322731973901 0.360618368127523 no 2142 0.335665231571573 3214 1886677 YPL242C IQG1
SGTC_1301 naphtanilide LB 4.81 µM -0.426783705008273 0.359794856475748 no 2143 0.334768438108638 3271 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2576 guaiol 23.12 µM -0.427391750130661 0.35959148733004 no 2144 0.334547007649857 3200 227829
SGTC_835 0312-0010 67.2 µM -0.427451976112654 0.359571346076025 no 2145 0.33452507841666 3122 1626196
SGTC_121 0557-0495 61.343 µM -0.430470127581536 0.358562492420707 no 2146 0.333426846088687 3192 3104427
SGTC_2150 5556613 200 µM -0.43240541098263 0.357916118965683 no 2147 0.332723393049891 3172 743190
SGTC_1933 st074711 15.9 µM -0.433010110604605 0.357714236187441 no 2148 0.332503712313654 3228 17250958
SGTC_203 k066-0004 30.888 µM -0.433118929371333 0.357677910580399 no 2149 0.332464185754286 3264 6795412
SGTC_1989 st071868 50.2 µM -0.434070779183963 0.357360221455577 no 2150 0.332118522015315 3271 16414057
SGTC_290 2043-6722 48.1 µM -0.435616024622741 0.356844691314436 no 2151 0.331557671151212 3257 773758 YLR208W SEC13
SGTC_706 4262-0057 46.9 µM -0.435771296080438 0.356792903546378 no 2152 0.331501335819025 3163 883298
SGTC_1039 k821-0043 94 µM -0.436297064272692 0.356617563419255 no 2153 0.331310605789385 3287 15992768
SGTC_576 1073-0113 22.7 µM -0.437384015568079 0.356255168627829 no 2154 0.330916437212475 3355 5439563
SGTC_409 arachidonic acid 100 µM -0.43897252705483 0.355725784760529 no 2155 0.330340721509288 3190 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1004 4084-0029 199 µM -0.439857597015242 0.355430948863211 no 2156 0.330020124364184 3290 716894 YLR208W SEC13
SGTC_3081 9117243 49.47 µM -0.440353779265586 0.35526569767804 no 2157 0.329840447821443 3323 45595589
SGTC_1796 st049173 110.4 µM -0.444517529310445 0.35388005514621 no 2158 0.32833422909873 3279 94134
SGTC_909 3448-9333 149 µM -0.445723712410684 0.353479013218189 no 2159 0.32789841689516 3164 3344074
SGTC_2049 5262831 67.185 µM -0.447249781753045 0.352971845860611 no 2160 0.327347360677231 3247 763417
SGTC_2725 haloperidol 53.21 µM -0.448994401327059 0.352392366347738 no 2161 0.326717847703604 3162 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.449047172124598 0.352374843732072 no 2162 0.326698814032121 3233 688788
SGTC_1148 3909-7663 27.7 µM -0.45026608306364 0.351970189955862 no 2163 0.326259295913337 3308 4084526
SGTC_2601 securinine 100 µM -0.450786763889283 0.351797385512238 no 2164 0.326071620928255 3170 442872 A GABA receptor antagonist.
SGTC_350 k064-0020 19.8 µM -0.452827682182113 0.35112033750702 no 2165 0.325336414308978 3346 2790705
SGTC_2912 7964298 10.93 µM -0.45301603744667 0.351057876879657 no 2166 0.325268596675308 3279 2975850
SGTC_3284 9108171 64.8615 µM -0.454152108494297 0.350681228906133 no 2167 0.324859675133752 3248 8687505
SGTC_2226 7298446 200 µM -0.455059258033366 0.35038058188901 no 2168 0.324533303868226 3292 3283010
SGTC_2904 7225135 42.03 µM -0.455176033862954 0.350341886910414 no 2169 0.32449130042733 3320 4446116
SGTC_1847 st056231 15 µM -0.456038569277575 0.350056124274452 no 2170 0.324181121708379 3189 5393180
SGTC_1491 4138-0063 26.5 µM -0.45624869591573 0.349986521038869 no 2171 0.324105575964925 3281 23883227
SGTC_868 0527-0199 213 µM -0.456319304866843 0.349963133362754 no 2172 0.324080191919472 3203 2849450
SGTC_2804 7954240 19.48 µM -0.456446013264743 0.349921165394782 no 2173 0.324034642072351 3298 828705
SGTC_126 0417-1624 672.48 µM -0.457410844336681 0.349601657162029 no 2174 0.323687885618089 3353 41912 YDL195W SEC31
SGTC_3106 9121286 49.47 µM -0.458597697799793 0.349208771302878 no 2175 0.323261545085259 3378 15943471
SGTC_1820 st053765 18.6 µM -0.460916137463947 0.348441761108172 no 2176 0.322429386726004 3268 3690829
SGTC_966 1300-0360 30.2 µM -0.462614734581913 0.347880206491824 no 2177 0.321820272582507 3198 70588
SGTC_2860 9025725 38.96 µM -0.463578708757642 0.347561665785385 no 2178 0.321474805744787 3167 40546248
SGTC_2649 anisomycin 9.56 µM -0.464404996346911 0.34728870859739 no 2179 0.32117880555106 3286 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1226 3909-7979 35.4 µM -0.465489445341759 0.34693059012893 no 2180 0.320790496802293 3322 6615510
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.465768578990557 0.346838433704937 no 2181 0.320690579089933 3238 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2704 st078022 71.1 µM -0.466651978933829 0.346546837523057 no 2182 0.320374445946701 3358 54697681
SGTC_1760 st045453 10.4495 µM -0.468821268472293 0.345831175756233 no 2183 0.319598698097846 3337 3323419 YIL048W NEO1
SGTC_347 4534-1311 26.2 µM -0.469308003904274 0.345670674309716 no 2184 0.31942474749673 3263 2862016
SGTC_1540 guanosine 70.6 µM -0.469398729130497 0.345640760650663 no 2185 0.3193923283038 3294 6802 Guanosine is a purine nucleoside
SGTC_1744 st037937 38.9 µM -0.46951935717734 0.345600989012773 no 2186 0.319349225959494 3378 1016152
SGTC_766 1391-0721 126 µM -0.469950135165653 0.345458973383823 no 2187 0.319195321972954 3349 1020919 YIL115C NUP159
SGTC_2163 5671233 125 µM -0.470109605663586 0.345406405871752 no 2188 0.319138355872296 3414 701023
SGTC_488 nitrendipine 139 µM -0.470965399239858 0.345124354875567 no 2189 0.318832722005972 3299 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_542 3381-0244 89.3 µM -0.471592126648007 0.34491785366889 no 2190 0.318608973806914 3372 1112843
SGTC_1179 1021-1431 9.29 µM -0.472629088145205 0.344576285360025 no 2191 0.318238913013865 3286 2840958
SGTC_248 streptozotocin 5.23457 mM -0.473911222956458 0.344154133740591 no 2192 0.317781607868366 3315 5300 DNA alkylating agent.
SGTC_2458 5808907 16.39 µM -0.474875500144725 0.343836766784158 no 2193 0.31743785750742 3373 2731747
SGTC_2571 chrysanthemic acid 100 µM -0.475072031864403 0.343772096927602 no 2194 0.317367816193422 3244 2743 An insecticide.
SGTC_935 2996-0153 430 µM -0.475101202964324 0.343762498404317 no 2195 0.317357420555265 3351 23738523
SGTC_99 0109-0120 622.8 µM -0.475314786123216 0.343692223597509 no 2196 0.31728131080309 3415 759414
SGTC_2962 9082311 13.18 µM -0.476317842138182 0.343362262517377 no 2197 0.316923978029758 3198 16459453
SGTC_564 3555-0129 330 µM -0.476341951165363 0.343354333181251 no 2198 0.31691539143083 3305 563260
SGTC_2081 5214970 32.255 µM -0.476587046281616 0.343273726561123 no 2199 0.316828104685669 3316 2063512
SGTC_3252 9135871 49.47 µM -0.477458085730582 0.342987317749725 no 2200 0.316517980304824 3356 17682838
SGTC_1936 st074407 74.3 µM -0.480852768220283 0.341871965133719 no 2201 0.315310571754451 3231 809813
SGTC_432 NS 1619 61.3 µM -0.481817286020517 0.341555315468873 no 2202 0.314967874293319 3365 4552 A K+/calcium channel activator.
SGTC_3177 9107506 49.47 µM -0.482002313598778 0.34149458394574 no 2203 0.314902151366703 3314 8897194
SGTC_1510 1123-0200 71.5 µM -0.486562429457762 0.339999119386821 no 2204 0.313284226912416 3444 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3035 9091303 49.47 µM -0.488198844131162 0.339463078026604 no 2205 0.312704501600012 3334 25237002
SGTC_2364 9055074 200 µM -0.489027092043965 0.339191892013686 no 2206 0.312411258297067 3326 6470630
SGTC_1404 3909-7820 48.3 µM -0.489670348143426 0.338981333710327 no 2207 0.312183593740582 3362 23741373
SGTC_2989 9073649 71.4286 µM -0.489740118283753 0.338958498733078 no 2208 0.312158904637188 3376 21367202
SGTC_680 0417-1641 114 µM -0.490125208001763 0.338832473874603 no 2209 0.312022650636519 3202 2835990
SGTC_1333 1482-0047 286 µM -0.490492919878375 0.33871215294152 no 2210 0.311892569333742 3371 3811116
SGTC_1931 st074438 57.1 µM -0.491924911082286 0.338243740522752 no 2211 0.311386213572536 3329 2787313
SGTC_2073 5212005 126 µM -0.492198211583417 0.338154370799549 no 2212 0.311289614310585 3271 691789
SGTC_1995 st072814 61.1 µM -0.49234041550697 0.338107873484018 no 2213 0.311239356848435 3270 5769371
SGTC_3328 9140624 29.0385 µM -0.49448509130548 0.337406915101088 no 2214 0.310481816405294 3381 4904392
SGTC_1184 1269-1718 139 µM -0.495087439582277 0.337210147004483 no 2215 0.310269199805658 3396 5403821
SGTC_2614 arthonioic acid 13.39 µM -0.495157930481128 0.33718712277036 no 2216 0.310244322105226 3324 6710684
SGTC_1887 st057648 70.8 µM -0.495623549439536 0.337035054345642 no 2217 0.310080017331234 3370 688672
SGTC_540 1187-0821 17.3 µM -0.497846360864489 0.336309464513387 no 2218 0.309296168185898 3267 847520
SGTC_1189 1431-2119 7.28 µM -0.499120440509723 0.335893842645645 no 2219 0.308847269187008 3383 3107275
SGTC_1257 0669-0121 16 µM -0.499472746545961 0.335778951075269 no 2220 0.308723190847325 3313 4307855
SGTC_1474 0330-0125 5.35 µM -0.50086221115783 0.335325978344651 no 2221 0.308234049533215 3392 X1474
SGTC_843 0310-0051 143 µM -0.501790351719832 0.335023532937783 no 2222 0.30790750033903 3321 2065037
SGTC_2640 pentamidine 10.38 µM -0.503434650481516 0.334487981704444 no 2223 0.307329357475371 3363 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1956 st077085 54 µM -0.50453107921135 0.334131059774742 no 2224 0.306944113963283 3305 24208685
SGTC_2466 5983409 37.09 µM -0.505206838796553 0.333911153507818 no 2225 0.306706783746926 3304 2879657
SGTC_199 4063-0024 41.6 µM -0.50601727189078 0.333647496877205 no 2226 0.306422262349842 3382 306215
SGTC_1645 Cervolide 78 µM -0.506662936078818 0.333437502969339 no 2227 0.306195670396107 3348 23173 A fragrance.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.508036802330416 0.332990844508156 no 2228 0.305713767039401 3524 5282309
SGTC_1691 st019933 84.6 µM -0.509145252374085 0.332630648255258 no 2229 0.305325207281983 3358 6176082
SGTC_1370 2001-0092 44.6 µM -0.510793294202477 0.332095394627017 no 2230 0.304747902615881 3473 790957
SGTC_731 3966-0296 387 µM -0.511594966383328 0.331835149984975 no 2231 0.304467254535955 3334 660956
SGTC_2869 9037858 32.47 µM -0.511700478580698 0.33180090388811 no 2232 0.304430325566187 3336 27187042
SGTC_687 k029-0044 34.9 µM -0.514080123372347 0.331028916266621 no 2233 0.303597986765065 3399 5829338
SGTC_2395 5646831 180.19 µM -0.514875138945998 0.330771162709735 no 2234 0.303320137283204 3438 6808628
SGTC_2473 5854593 8.94 µM -0.515081107798704 0.330704398222655 no 2235 0.303248171901867 3245 2872951
SGTC_2993 9054257 71.4286 µM -0.515191049375051 0.330668763034143 no 2236 0.303209761512583 3332 6470217 YGL055W OLE1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.516390758807812 0.330280002932476 no 2237 0.302790759400158 3431 688801
SGTC_2974 9094440 9.66 µM -0.517080647584825 0.330056530678496 no 2238 0.302549931167783 3441 25236134
SGTC_1270 0831-1170 17.3 µM -0.517136460031943 0.330038454278598 no 2239 0.30253045176286 3404 6764716
SGTC_2741 miltefosine 3.04 µM -0.518647388749918 0.329549249243979 no 2240 0.302003328107971 3294 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1997 st073024 93.8 µM -0.518886729941164 0.329471782630438 no 2241 0.301919866065572 3400 686268
SGTC_1779 st039427 55 µM -0.519374731877022 0.329313855655124 no 2242 0.301749724220074 3463 1124498
SGTC_1091 telmisartan 47.6 µM -0.519603485897608 0.329239836857572 no 2243 0.30166998398592 3422 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1008 4106-0037 6 µM -0.520480177445732 0.328956224476959 no 2244 0.301364470198557 3382 2905394
SGTC_3347 9188721 44.724 µM -0.520547568182402 0.328934427441356 no 2245 0.301340991309225 3376 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_402 epigallocatechin gallate 10 µM -0.521275183386089 0.328699122743844 no 2246 0.301087543109427 3321 65064 An antioxidant.
SGTC_2310 7668677 200 µM -0.525108024705719 0.327460736476177 no 2247 0.299754048953628 3488 2197143
SGTC_181 1447-1644 8.07 µM -0.52732836386304 0.326744214047559 no 2248 0.298982790326524 3382 534600
SGTC_960 1222-0186 7.7 µM -0.527765872414815 0.326603101517217 no 2249 0.298830923388057 3417 3126296
SGTC_2715 st079500 56.4 µM -0.528641908796712 0.326320622277434 no 2250 0.298526941114014 3347 28246688
SGTC_2118 5526350 200 µM -0.52935196344881 0.326091737160048 no 2251 0.298280657317759 3380 743594
SGTC_1459 k035-0031 35.7 µM -0.529501042602108 0.326043690021926 no 2252 0.298228960684941 3316 3877128 YMR208W ERG12
SGTC_1925 st057770 10.1 µM -0.529798833709521 0.325947722738016 no 2253 0.298125706971728 3307 5989122
SGTC_2471 5466956 24.79 µM -0.530046455028178 0.325867932137853 no 2254 0.298039861134373 3300 724419
SGTC_3092 9117248 49.47 µM -0.530330385685016 0.325776451455218 no 2255 0.297941441371497 3410 17141857
SGTC_2222 6885208 172.143 µM -0.530345642535367 0.325771536090332 no 2256 0.29793615326169 3370 609514
SGTC_3055 9094636 49.47 µM -0.530635173384541 0.325678262437302 no 2257 0.297835808358929 3488 25236176
SGTC_2197 6588183 93.1375 µM -0.531231785105909 0.32548609572947 no 2258 0.297629084725857 3365 884136
SGTC_83 0170-0301 39.027 µM -0.531281012708236 0.325470241748504 no 2259 0.297612030478661 3374 3089716
SGTC_2388 9080168 200 µM -0.531291946878419 0.325466720390406 no 2260 0.297608242541561 3311 15943073
SGTC_1291 0993-0025 5.79 µM -0.535322681834527 0.324169682697227 no 2261 0.296213372337611 3464 4353356
SGTC_2432 5630864 12.22 µM -0.535913570060662 0.323979721342834 no 2262 0.296009142719293 3428 5714970
SGTC_164 4100-3994 89.624 µM -0.536900595763406 0.323662510195205 no 2263 0.295668139731549 3485 4615967
SGTC_887 0885-0007 9.62 µM -0.537605944848275 0.323435902963192 no 2264 0.295424562576725 3439 5719458
SGTC_1157 4092-0394 27.6 µM -0.538927864800044 0.323011386632584 no 2265 0.294968314699427 3518 3659885
SGTC_740 k014-0057 261 µM -0.539524491586203 0.322819863624757 no 2266 0.294762501123106 3403 4012779
SGTC_2967 9089538 49.85 µM -0.539805412211785 0.322729701634662 no 2267 0.294665617112844 3473 728216
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.54045037107523 0.322522740336757 no 2268 0.294443239049379 3385 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_443 clozapine 122 µM -0.540713332408113 0.322438374266925 no 2269 0.294352593748875 3388 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1919 st067113 52.3 µM -0.541559792399433 0.322166866015386 no 2270 0.294060898382192 3423 1268243
SGTC_481 bay k-8644 50 µM -0.541785886829526 0.32209436061646 no 2271 0.293983007455137 3365 2303 A calcium channel antagonist.
SGTC_2255 7941087 197.44 µM -0.542040473515816 0.322012726243714 no 2272 0.293895312189915 3468 935561
SGTC_1874 staurosporine 7.6 µM -0.542095388029858 0.321995118782178 no 2273 0.293876397850533 3437 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_326 k292-0812 17.5 µM -0.542208808101906 0.321958753713208 no 2274 0.293837334082231 3395 3579357
SGTC_3005 9076496 71.4286 µM -0.542526508961873 0.321856900628811 no 2275 0.293727925386395 3427 21368410
SGTC_198 3454-2873 16.191 µM -0.542868474085432 0.321747283515344 no 2276 0.293610181721084 3358 710957
SGTC_2736 butenafine 14.65 µM -0.543774055539982 0.32145707382763 no 2277 0.293298482192952 3345 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_169 k015-0017 16.025 µM -0.543922709117497 0.321409445549508 no 2278 0.293247330553152 3524 1840002
SGTC_3058 9093861 49.47 µM -0.544408589719919 0.32125379096345 no 2279 0.293080168076663 3480 17217477
SGTC_20 0481-0013 4.944 µM -0.54633025699174 0.320638481854662 no 2280 0.292419470696572 3421 182045
SGTC_2581 avocatin a 64 µM -0.547196418729034 0.320361301735294 no 2281 0.292121898156985 3350 6710728 A skin care supplement.
SGTC_2116 5511452 16.8835 µM -0.54796933448256 0.320114045810018 no 2282 0.29185647961009 3457 870744
SGTC_585 0kpi-0023 191 µM -0.549348809023802 0.319672950117494 no 2283 0.291383048713005 3405 64601
SGTC_1349 flufenamic acid 69 µM -0.549979242897037 0.31947144974708 no 2284 0.291166805349889 3393 3371 A non-steroidal anti-inflammatory.
SGTC_2303 7774051 200 µM -0.55106226133723 0.319125417950659 no 2285 0.290795497256906 3472 2953184
SGTC_2326 6164455 177.58 µM -0.557966782204728 0.31692309033491 no 2286 0.288433533652067 3399 2888790
SGTC_266 formosanin C 406 nM -0.558555257999354 0.316735683037823 no 2287 0.288232641226459 3408 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2160 5660466 132.927 µM -0.558569981713636 0.316730994694166 no 2288 0.288227615727336 3449 2859134
SGTC_1728 st035614 33.7865 µM -0.560618094661667 0.316079119115812 no 2289 0.287528956759074 3393 15945546
SGTC_479 n-linoleoylglycine 10 µM -0.561164271821044 0.315905377682721 no 2290 0.28734277835245 3423 6433346 An anti-infammatory.
SGTC_1293 1000-1278 195 µM -0.564756636449322 0.31476364484266 no 2291 0.286119652789359 3512 678847
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.565484025851267 0.314532679363998 no 2292 0.285872293245807 3362 803109
SGTC_305 1682-2595 20.8 µM -0.566978285439441 0.314058439924657 no 2293 0.285364467358567 3455 226033
SGTC_3139 9095020 49.47 µM -0.567011799728714 0.314047806869928 no 2294 0.285353082415817 3340 25236292
SGTC_798 1287-0182 476 µM -0.568511977052892 0.313572004895098 no 2295 0.284843687685037 3516 1649755
SGTC_2710 st078562 53.7235 µM -0.569458441045772 0.313271980181923 no 2296 0.284522533194902 3425 17250908
SGTC_3109 9122853 49.47 µM -0.569942593548867 0.31311855382627 no 2297 0.284358317288142 3442 1234709
SGTC_1948 st076329 66.6 µM -0.57075781747057 0.312860285118155 no 2298 0.284081910238798 3408 24208413
SGTC_1145 3546-0597 10.2 µM -0.571790150517213 0.312533366474744 no 2299 0.283732075430043 3404 875334
SGTC_1809 st050081 57.6 µM -0.572183291102713 0.312408905695578 no 2300 0.283598903056616 3553 5036894
SGTC_1920 st075728 45.7 µM -0.574610428390244 0.311640994783844 no 2301 0.282777398820895 3521 3400306
SGTC_2111 5486399 200 µM -0.57634291033593 0.31109336305652 no 2302 0.282191712126903 3481 689674
SGTC_1308 1187-1617 41.4 µM -0.578885063142153 0.310290553893538 no 2303 0.281333364745427 3482 2882570
SGTC_132 0417-1715 25.805 µM -0.579714743140916 0.310028737115482 no 2304 0.2810534997461 3548 6769098
SGTC_937 3122-0005 46.7 µM -0.580274183894164 0.309852252342893 no 2305 0.280864866940254 3499 759535
SGTC_2867 9039098 71.43 µM -0.581781300094032 0.309377025878181 no 2306 0.280357000709294 3475 6463460
SGTC_1888 azatryptophan 97.5 µM -0.582272721869901 0.309222138772065 no 2307 0.280191498174209 3464 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_65 0798-0905 34.986 µM -0.583132405532874 0.308951263824237 no 2308 0.279902085156353 3657 3602145
SGTC_2287 7945887 168.79 µM -0.583990294628415 0.308681057854169 no 2309 0.279613420875829 3476 1245853
SGTC_858 0438-0351 2.77 µM -0.584481827959842 0.308526288176385 no 2310 0.279448093876715 3463 2799119
SGTC_557 1315-0110 16.2 µM -0.584597375023738 0.308489910673465 no 2311 0.279409236570544 3479 6833801
SGTC_496 calpeptin 138 µM -0.585057526772466 0.308345060465239 no 2312 0.279254518244722 3461 73364 A calpain inhibitor.
SGTC_2842 9000675 19.48 µM -0.585646846709377 0.308159593244371 no 2313 0.279056430103603 3433 2989072
SGTC_3031 9088762 49.47 µM -0.586976480043148 0.307741318994954 no 2314 0.278609751544196 3438 205253
SGTC_2560 caryophyllene 100 µM -0.587013493214109 0.307729679012401 no 2315 0.278597322279716 3479 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_251 melphalan 456.522 µM -0.587886349721129 0.307455237312914 no 2316 0.278304289665088 3516 460612 A DNA alkylator.
SGTC_729 4092-0585 94.1 µM -0.590217082889733 0.306722941441155 no 2317 0.277522560363906 3429 2169061
SGTC_3172 9105863 49.47 µM -0.590310709368808 0.30669354090882 no 2318 0.277491180419596 3474 2348785
SGTC_2314 7727897 200 µM -0.590598508254109 0.306603174258724 no 2319 0.277394732317334 3435 900724
SGTC_2505 galangin 7.89 µM -0.591894600874067 0.306196356832348 no 2320 0.276960584739452 3430 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_747 3448-8087 38.7 µM -0.592298378806899 0.306069667826986 no 2321 0.276825400661321 3460 5168703
SGTC_1952 st077036 64.1 µM -0.593060095215518 0.305830735516522 no 2322 0.276570467491579 3530 2937007
SGTC_3169 9102970 49.47 µM -0.594068181613259 0.305514649838782 no 2323 0.276233255629672 3549 17027839
SGTC_1433 4060-0023 7.6 µM -0.595268950567889 0.305138337608707 no 2324 0.275831853596201 3515 3840627
SGTC_1893 st059353 36.1 µM -0.595943644326078 0.304926983834982 no 2325 0.275606437745849 3479 3112488
SGTC_622 1348-1566 26.3 µM -0.596060756431316 0.304890304059773 no 2326 0.275567319703744 3502 7340407
SGTC_2630 antimycin a 100 µM -0.599721901344488 0.303744615424985 no 2327 0.27434579479472 3475 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_719 2810-4230 27.3 µM -0.600122540843554 0.303619359287359 no 2328 0.274212285627344 3485 721079
SGTC_936 3005-4620 401 µM -0.60027355207245 0.303572153044436 no 2329 0.274161970950721 3551 777207
SGTC_2304 7443016 91.4 µM -0.600577027697749 0.303477296209589 no 2330 0.274060871216696 3486 939854
SGTC_1495 4469-0029 237 µM -0.601382884768139 0.303225475184497 no 2331 0.273792497790932 3518 793680
SGTC_2016 5121758 140 µM -0.602216976789584 0.302964929503501 no 2332 0.2735148582648 3518 2795203
SGTC_1644 st010134 20.9 µM -0.602218239472507 0.302964535154658 no 2333 0.27351443806829 3510 3818134
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.603704874230797 0.30250040330884 no 2334 0.273019936470713 3495 75037 A free radical scavenger.
SGTC_635 k038-0028 24.7 µM -0.604486620627344 0.302256467685891 no 2335 0.272760080894273 3488 4035102
SGTC_174 3553-0389 74.3 µM -0.60648234207433 0.301634124786018 no 2336 0.272097252234801 3541 738071
SGTC_764 1951-2361 146 µM -0.607075900909718 0.301449141507557 no 2337 0.271900271220805 3427 5438930
SGTC_2951 9072950 58.06 µM -0.607639703220073 0.301273479181206 no 2338 0.271713231054836 3559 16488155
SGTC_2820 7989630 71.43 µM -0.60790645748972 0.301190383360023 no 2339 0.271624758242236 3443 2984098
SGTC_2635 hydroquinidine 100 µM -0.608501316869899 0.301005117696721 no 2340 0.27142751641702 3514 442912 An experimental heart treatment.
SGTC_683 panaxydol 45 µM -0.608736832030293 0.300931782001636 no 2341 0.271349444675802 3531 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1856 st057054 55.7 µM -0.609670182822415 0.300641230596578 no 2342 0.271040155061701 3618 1266018
SGTC_424 splitomicin 100 mM -0.610106210193556 0.300505539012718 no 2343 0.270895726547328 3503 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2654 protoveratrine a 100 µM -0.610603432809431 0.300350837251313 no 2344 0.27073107477033 3504 5702278 A heart drug and vasodilator.
SGTC_1706 st031321 9.9705 µM -0.611796940577195 0.299979646000716 no 2345 0.270336057079955 3539 6103185
SGTC_1276 0871-0068 94.2 µM -0.612747769187646 0.29968407871541 no 2346 0.270021565736515 3486 3414906
SGTC_2084 5306078 60.6385 µM -0.614485752117789 0.299144163916748 no 2347 0.269447192680792 3459 679340
SGTC_899 1083-0020 478 µM -0.616060909780469 0.298655213507373 no 2348 0.268927160125368 3590 767123
SGTC_1006 4099-6547 255 µM -0.618928192807292 0.29776610387752 no 2349 0.267981832392878 3553 3146833
SGTC_2123 5259487 200 µM -0.619526091976505 0.297580854855139 no 2350 0.267784919304223 3532 2173474
SGTC_525 k781-2675 26.7 µM -0.620330415944882 0.297331731594249 no 2351 0.267520136981716 3581 3651118 YDL195W SEC31
SGTC_756 0508-1999 28.3 µM -0.621714994735891 0.296903109350076 no 2352 0.267064645020718 3458 6753853
SGTC_1107 amlodipine 47 µM -0.622301262336832 0.296721704498882 no 2353 0.266871895650658 3482 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1494 4358-1428 177 µM -0.622421413623981 0.29668453315909 no 2354 0.266832401746934 3586 1564571
SGTC_1502 4534-4282 27.7 µM -0.622703647649776 0.296597226487566 no 2355 0.266739642627632 3523 3278949
SGTC_1499 4480-0877 67.3 µM -0.622872943262387 0.296544861991766 no 2356 0.266684009702228 3500 2861909
SGTC_3134 9127454 49.47 µM -0.62526044492889 0.295806840022994 no 2357 0.265900068145318 3644 24262820
SGTC_775 4577-0580 57.3 µM -0.62631805021246 0.295480184092996 no 2358 0.265553174646796 3630 2006902
SGTC_92 0063-0024 660.874 µM -0.626355466685122 0.295468630540142 no 2359 0.265540906286038 3608 3594437
SGTC_1643 st009866 20.2 µM -0.62659723421148 0.295393981962463 no 2360 0.265461640880458 3553 3156273 YOR207C RET1
SGTC_3260 9137109 49.47 µM -0.627190283938322 0.295210907613634 no 2361 0.265267255668843 3459 17478346
SGTC_1492 4158-0558 28.5 µM -0.627290565876441 0.295179955760206 no 2362 0.265234393181944 3552 3967268
SGTC_426 0988-0037 14.6 µM -0.627922242260294 0.294985024250638 no 2363 0.265027439756593 3587 5383008
SGTC_2268 7933382 153.85 µM -0.627989689945383 0.294964213808079 no 2364 0.265005347009239 3597 935025 YOR257W CDC31
SGTC_1815 st051655 58.2 µM -0.629790303614417 0.294408899155518 no 2365 0.264415895249497 3538 5984156
SGTC_1214 0358-0031 63.7 µM -0.630326707758443 0.294243563866118 no 2366 0.264240426234205 3612 4301366
SGTC_642 0335-0876 158 µM -0.631786647282941 0.293793785602297 no 2367 0.263763149995284 3587 6812350
SGTC_3150 9097574 49.47 µM -0.632452126110606 0.293588870441086 no 2368 0.263545740898064 3545 17217476
SGTC_401 neomycin 50 µM -0.634252369028964 0.293034869059871 no 2369 0.26295806785702 3516 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1845 st056753 3.01 µM -0.635163761689312 0.292754584835282 no 2370 0.262660807580293 3518 5375839
SGTC_623 k072-0108 16.9 µM -0.635268801786522 0.292722289436987 no 2371 0.262626558703847 3541 5382803
SGTC_1180 1193-0155 285 µM -0.635519988180972 0.292645066928014 no 2372 0.262544667325277 3574 2921347
SGTC_754 3474-0146 171 µM -0.635728619372411 0.29258093440715 no 2373 0.262476659661812 3506 24762078
SGTC_730 1436-0052 41.2 µM -0.637509213205305 0.292033851793662 no 2374 0.261896605334127 3589 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1427 4048-4900 550 nM -0.63780926251571 0.291941709365005 no 2375 0.261798924668717 3584 24132586
SGTC_1914 st062367 72.6 µM -0.638151779685812 0.291836541992478 no 2376 0.261687441494082 3555 978205
SGTC_2686 alizarin 95.37 µM -0.640244980850901 0.291194223825324 no 2377 0.261006671906101 3526 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1915 st067105 30.6 µM -0.640378926810345 0.291153143746803 no 2378 0.260963139823464 3587 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_597 k018-0003 82.8 µM -0.640458476730827 0.291128747748459 no 2379 0.260937288076874 3641 6786234
SGTC_2419 paclitaxel 166.5 µM -0.641377187609747 0.290847070983462 no 2380 0.260638825342781 3529 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2968 9090663 33.37 µM -0.641846255252806 0.290703303983959 no 2381 0.260486506549739 3516 25236811
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.643071241434407 0.290328008373056 no 2382 0.260088937093699 3538 688803
SGTC_2248 tofa 1.1 µM -0.644495429425385 0.289891969310642 no 2383 0.259627110249272 3540 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3171 9103192 49.47 µM -0.644753897010006 0.289812868061061 no 2384 0.259543341394661 3626 13018434
SGTC_2100 5377183 190 µM -0.644957370753363 0.289750604214598 no 2385 0.259477405759404 3610 2844202
SGTC_864 0469-0573 172 µM -0.645545111698975 0.28957078820073 no 2386 0.259286996993945 3523 689425
SGTC_1197 1601-0112 267 µM -0.646545691168252 0.289264787161143 no 2387 0.258963008276474 3571 7350313
SGTC_2066 5222451 176 µM -0.647138652644266 0.289083517167477 no 2388 0.258771105572602 3605 2281147
SGTC_879 0831-1030 162 µM -0.647662705950748 0.288923357081267 no 2389 0.258601565206011 3617 1549252
SGTC_25 0118-0223 35.662 µM -0.650323493898406 0.288110817479182 no 2390 0.257741642203726 3631 5333628
SGTC_1149 3909-7961 23.3 µM -0.652430092849282 0.287468279426984 no 2391 0.257061878290636 3563 735261
SGTC_2214 7179297 48.276 µM -0.653123660204876 0.287256881411754 no 2392 0.256838280023992 3613 769744
SGTC_1686 st019653 115.5 µM -0.654537582471813 0.286826148601008 no 2393 0.256382761196524 3616 97252
SGTC_1187 1391-0724 117 µM -0.65522816047761 0.286615884420802 no 2394 0.256160433010813 3635 6997986
SGTC_638 3970-0837 4.09 µM -0.657750603961302 0.285848483663754 no 2395 0.255349199851753 3593 4118451 YLR208W SEC13
SGTC_1780 st038448 24.544 µM -0.660560339196992 0.284994832387323 no 2396 0.254447155356287 3642 728868 YDL195W SEC31
SGTC_1375 2910-0797 186 µM -0.660941636371274 0.284879080764999 no 2397 0.254324871554723 3595 742508
SGTC_3216 9129716 49.47 µM -0.662054410729556 0.284541400532302 no 2398 0.253968175790277 3580 8056934
SGTC_974 1326-0144 138 µM -0.662094669260814 0.284529187344685 no 2399 0.253955275987062 3639 5411856
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.662317976793218 0.284461447323616 no 2400 0.253883729117807 3632 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1359 1582-0056 520 nM -0.66286217632144 0.284296397447294 no 2401 0.253709414011966 3642 3661189
SGTC_2174 5790901 200 µM -0.665145635812175 0.283604348141298 no 2402 0.252978674066887 3622 786020
SGTC_108 0509-0257 621.132 µM -0.667845284929076 0.282787206631487 no 2403 0.25211617826155 3613 536624
SGTC_2910 7948405 25.97 µM -0.667999786859488 0.282740475554511 no 2404 0.252066864272216 3582 2971328
SGTC_2966 9084041 48.03 µM -0.668365877839402 0.282629761488063 no 2405 0.25195003552115 3544 17741380
SGTC_455 paf C-16 10 µM -0.672311264270101 0.281437912999924 no 2406 0.250692780092694 3601 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1269 0831-0796 3.05 µM -0.672697788197347 0.281321279850291 no 2407 0.250569787507807 3627 927758
SGTC_2157 5649910 96.377 µM -0.676185568956219 0.28026990251015 no 2408 0.249461416862474 3613 2858091
SGTC_1663 st014140 55.4 µM -0.677877648286149 0.279760518635016 no 2409 0.248924636540474 3706 4207120
SGTC_2265 7929201 200 µM -0.678739221279915 0.279501323238064 no 2410 0.24865155510072 3641 1265108
SGTC_1134 3477-0009 42.5 µM -0.68071597246753 0.278907078989936 no 2411 0.248025613837502 3687 3973534
SGTC_490 phenamil 164 µM -0.681869190311574 0.278560686681396 no 2412 0.247660834328719 3583 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1979 st071809 45.3 µM -0.684278213915239 0.277837764474721 no 2413 0.246899750660255 3708 4976333
SGTC_2259 7964009 200 µM -0.685213372682383 0.277557380335023 no 2414 0.246604643257851 3660 313134
SGTC_1594 piperine 70.1 µM -0.685673699929927 0.277419413437613 no 2415 0.2464594475291 3656 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1408 3909-7976 48.8 µM -0.688001301046963 0.276722310685257 no 2416 0.245725981029761 3695 24152374
SGTC_1084 voriconazole 435 nM -0.688391266434024 0.276605602356589 no 2417 0.245603211066733 3661 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2653 dihydrofissinolide 100 µM -0.688576734642599 0.276550104141768 no 2418 0.245544833023824 3683 6857746
SGTC_342 k048-0088 23.3 µM -0.68914414742341 0.276380349397565 no 2419 0.245366280259949 3642 6820570
SGTC_2930 9013230 14.89 µM -0.689842395974702 0.276171522257315 no 2420 0.245146652063542 3644 2995857
SGTC_335 4077-0256 27.6 µM -0.691110526907918 0.275792456965804 no 2421 0.244748042679847 3685 3121989
SGTC_2841 9004761 38.96 µM -0.692933032687611 0.275248128034751 no 2422 0.244175789246816 3589 2991039
SGTC_2648 atorvastatin 78.68 µM -0.693118348432943 0.275192809301922 no 2423 0.244117641899269 3675 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3072 9116419 49.47 µM -0.695117222076476 0.274596472318676 no 2424 0.243490921345643 3643 17170162
SGTC_911 3456-4043 236 µM -0.695351629499975 0.274526581808311 no 2425 0.243417482961796 3742 914281
SGTC_1347 1493-0251 600 nM -0.695441873709207 0.274499677091676 no 2426 0.243389213204766 3699 3986378
SGTC_320 4092-0846 5.34 µM -0.695991787502902 0.274335758134805 no 2427 0.243216986435691 3642 1359356
SGTC_1139 k015-0024 46.9 µM -0.696122817022196 0.274296707830269 no 2428 0.243175959196429 3653 2766652
SGTC_1144 3486-0183 12.5 µM -0.696970470351535 0.274044150773288 no 2429 0.242910637090901 3687 6744069
SGTC_1121 fusaric acid 630.51 nM -0.699461505711811 0.273302616152461 no 2430 0.242131830869671 3678 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3078 9116413 49.47 µM -0.699657104304785 0.273244432219574 no 2431 0.242070735601476 3621 17177322
SGTC_1879 gemcitabine 100 µM -0.699837242612109 0.273190852624663 no 2432 0.242014476752571 3683 60750 A nucleoside analog which inhibits DNA replication.
SGTC_875 0709-0210 25.7 µM -0.700586851698142 0.272967947907815 no 2433 0.24178044311592 3685 6251364
SGTC_3066 9117245 49.47 µM -0.701007217489527 0.272842986874146 no 2434 0.241649255499462 3737 17176980
SGTC_2425 5628681 7.85 µM -0.704354285071371 0.271849026458188 no 2435 0.240606083860574 3706 5714958
SGTC_2772 vinpocetine 57.06 µM -0.706977790126574 0.271071200006604 no 2436 0.239790139999799 3701 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2919 7978188 46.38 µM -0.707387760480117 0.270949750843244 no 2437 0.239662770466417 3665 2980291
SGTC_344 k064-0035 6.43 µM -0.707397010188081 0.270947011033216 no 2438 0.239659897194409 3664 5088750
SGTC_77 0828-0286 12.516 µM -0.708091333055023 0.270741388579149 no 2439 0.239444270719267 3658 745345
SGTC_3135 9127742 49.47 µM -0.708415013394067 0.270645557868444 no 2440 0.239343785905748 3716 3643468
SGTC_695 3505-6186 243 µM -0.711180426876879 0.269827504506782 no 2441 0.238486218012751 3693 1819379
SGTC_3067 9117431 49.47 µM -0.711263952705655 0.269802815510378 no 2442 0.238460342453221 3713 17150885
SGTC_3214 9129694 49.47 µM -0.712749392040355 0.269363930693198 no 2443 0.238000423389082 3668 17158655
SGTC_1079 idarubicin 2.36 µM -0.713572265407958 0.269120960404768 no 2444 0.237745856254545 3667 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_35 0133-0054 64.071 µM -0.713608257277597 0.269110335575609 no 2445 0.237734725087609 3663 99677
SGTC_998 3996-0085 177 µM -0.7140607509346 0.268976777040302 no 2446 0.237594807252485 3732 715391
SGTC_2132 5317594 122.667 µM -0.715755772934002 0.268476768407303 no 2447 0.237071082902896 3682 794577
SGTC_943 3253-1379 105 µM -0.716144340350767 0.268362212135779 no 2448 0.23695111359919 3691 668464
SGTC_1852 st056254 31.4 µM -0.71651124509967 0.268254064957137 no 2449 0.236837863234414 3660 442583
SGTC_2092 5303694 80.6725 µM -0.716555653450139 0.268240976840983 no 2450 0.236824157985386 3700 1963699
SGTC_414 piperonyl butoxide 100 µM -0.71865184145636 0.267623549933306 no 2451 0.236177731456167 3685 5794 A potent inhibitor of cytochrome P450.
SGTC_1608 st001473 40.5 µM -0.720152713791098 0.267181912274196 no 2452 0.235715487230898 3672 7292267
SGTC_2552 juarezic acid 87.02 µM -0.720603382981877 0.26704937292028 no 2453 0.23557678592186 3755 1549512
SGTC_1829 berberine 14.4 µM -0.720616361174699 0.267045556596332 no 2454 0.23557279232359 3712 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.721037152024772 0.266921835170902 no 2455 0.235443328462947 3694 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2462 5162487 171.77 µM -0.721353763618119 0.266828763747479 no 2456 0.235345943113239 3657 2259986
SGTC_2681 menadione 3.18 µM -0.721982928442453 0.266643862583165 no 2457 0.235152486721322 3733 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2541 muurolladie-3-one 83.07 µM -0.722969026832145 0.266354194917486 no 2458 0.234849456720074 3732 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_816 0325-0417 81.3 µM -0.724768943263417 0.265825878059882 no 2459 0.234296895758765 3728 68101
SGTC_1940 st075990 51.1 µM -0.725343853118318 0.265657240783124 no 2460 0.234120554458297 3798 1084979
SGTC_1288 0973-0013 65.5 µM -0.726006589219536 0.265462908926785 no 2461 0.233917365562327 3748 4315430
SGTC_1403 3909-7815 62.9 µM -0.726109254896655 0.26543281107238 no 2462 0.23388589793639 3671 6615483
SGTC_1323 1348-1351 11.2 µM -0.727556420133291 0.265008739005157 no 2463 0.233442583036956 3682 6989654
SGTC_1514 1189-1591 158 µM -0.728096956554833 0.264850430514144 no 2464 0.233277118377058 3734 767698 YMR146C TIF34
SGTC_1833 st055984 71 µM -0.72835127122953 0.264775965259986 no 2465 0.233199292136037 3757 676288
SGTC_873 0591-4978 488 µM -0.728372774031666 0.264769669565507 no 2466 0.233192712436328 3749 3305145
SGTC_1794 st048918 76.9 µM -0.729638219732396 0.264399300338028 no 2467 0.2328056768667 3641 672303
SGTC_1150 3909-7983 10.9 µM -0.731459955586817 0.263866580204019 no 2468 0.232249127704125 3728 23965914
SGTC_411 enrofloxacin 100 µM -0.731517546963456 0.263849748003858 no 2469 0.232231545339048 3775 71188 A bacterial gyrase inhibitor.
SGTC_196 k015-0023 18.111 µM -0.733765897087802 0.263193052081806 no 2470 0.231545714250398 3713 5211998
SGTC_2833 9001315 45.46 µM -0.733845930508333 0.263169691396995 no 2471 0.231521321884479 3727 2989378
SGTC_2733 amorolfine 100 µM -0.733854409271713 0.263167216621445 no 2472 0.231518737834204 3746 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_924 2046-0044 21.3 µM -0.733958599582251 0.263136806596926 no 2473 0.231486985341777 3731 3623589
SGTC_3161 9100388 49.47 µM -0.73424683868626 0.263052687608462 no 2474 0.231399155755096 3743 25236368
SGTC_575 k072-0246 11.9 µM -0.734840809311247 0.262879388037061 no 2475 0.231218225068562 3757 6796779
SGTC_428 3448-4153 16.5 µM -0.737843866515939 0.262004097000399 no 2476 0.230304666587496 3710 3834874
SGTC_1763 st044482 94.5 µM -0.739071075652874 0.261646836975181 no 2477 0.229931919702832 3768 88505
SGTC_1508 1080-0625 72.9 µM -0.740279947044284 0.261295159943921 no 2478 0.229565073029425 3663 767111
SGTC_2563 tomatine 8.54 µM -0.740578360733563 0.261208384752633 no 2479 0.229474566269607 3691 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1320 1313-0481 95.3 µM -0.743266532547854 0.26042736407221 no 2480 0.228660164766359 3740 6813365 YLR208W SEC13
SGTC_1074 carmofur 3.8 µM -0.743935582044567 0.260233165715255 no 2481 0.228457723817031 3774 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1524 corynanthine 62.1 µM -0.744239700461181 0.260144916957701 no 2482 0.228365736987453 3847 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_103 0844-0104 51.839 µM -0.744554891491239 0.260053471442414 no 2483 0.228270422988113 3752 5375804
SGTC_1394 3474-0001 65.7 µM -0.745473965602198 0.259786917629898 no 2484 0.227992622006479 3727 5017666 YIL048W NEO1
SGTC_1774 st048371 48.465 µM -0.745517505986455 0.259774293359601 no 2485 0.227979466131809 3740 4242727
SGTC_2343 7990716 14.84 µM -0.745743767056962 0.259708695431979 no 2486 0.22791110745823 3733 6456862
SGTC_2323 6148992 148.28 µM -0.745925064049946 0.259656139723355 no 2487 0.227856341789739 3737 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_435 c-PAF 6.7 µM -0.748039798546407 0.259043510656754 no 2488 0.227218076151154 3776 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1872 amphotericin b 148 nM -0.748259256900233 0.258979977395891 no 2489 0.227151897356412 3773 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2992 9074591 71.4286 µM -0.748567121977146 0.258890863946923 no 2490 0.227059077374492 3734 17741321
SGTC_813 k007-0158 173 µM -0.749148984409797 0.258722483605404 no 2491 0.226883706797388 3780 6523916
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.749856991929797 0.25851767566117 no 2492 0.226670419769338 3800 279621
SGTC_1315 1237-0019 3.69 µM -0.75286744307658 0.257647769882234 no 2493 0.225764786956021 3742 825140
SGTC_3201 9113999 49.47 µM -0.753003042889879 0.257608622501064 no 2494 0.225724042746781 3794 16649224
SGTC_178 4092-0806 87.505 µM -0.754491832340894 0.257179015326381 no 2495 0.225276973969565 3723 2169044
SGTC_3054 9094397 49.47 µM -0.754704995500119 0.257117535165452 no 2496 0.22521300424223 3776 2598354
SGTC_1669 st015249 58.4 µM -0.755423000220966 0.256910505690655 no 2497 0.224997608546648 3836 722793
SGTC_902 1120-0002 2.07 µM -0.756528865182157 0.25659181035908 no 2498 0.224666086365911 3751 3280475
SGTC_1498 4478-3555 97.6 µM -0.756560913769224 0.2565825774605 no 2499 0.224656482799996 3736 3437919
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.756718498269741 0.256537181355102 no 2500 0.224609264974997 3755 6857784
SGTC_685 1278-0033 54.9 µM -0.756844006267057 0.256501028671474 no 2501 0.224571662419448 3793 3590572
SGTC_598 3937-0236 20.2 µM -0.760013731685089 0.25558886732627 no 2502 0.223623188437257 3841 1379313
SGTC_2237 6667747 47.222 µM -0.760094560392197 0.255565629181229 no 2503 0.223599031961229 3739 729940 YDL015C TSC13
SGTC_855 0428-0020 25 µM -0.761537123030126 0.25515108004087 no 2504 0.223168157196678 3793 6812414
SGTC_847 0342-0274 5.54 µM -0.764123324143149 0.254408764882214 no 2505 0.222396877019942 3781 18097
SGTC_1506 4226-2149 212 µM -0.764298335385107 0.254358572469581 no 2506 0.222344738575087 3816 991114
SGTC_2101 5377231 179.231 µM -0.765665276734762 0.253966718692373 no 2507 0.221937746471365 3818 2844213
SGTC_1452 4194-0072 190 µM -0.765816812266634 0.253923298323611 no 2508 0.221892654603175 3772 1343545
SGTC_1813 st051246 8.6015 µM -0.768072116316959 0.253277533517793 no 2509 0.221222170797002 3708 5291959
SGTC_2520 obtusaquinone 4.71 µM -0.768602492968284 0.253125795427487 no 2510 0.221064662557348 3808 5967872
SGTC_2381 9035592 200 µM -0.769233377208142 0.252945364907555 no 2511 0.220877389742762 3809 4749657
SGTC_860 0443-0016 25.1 µM -0.76938382937528 0.252902346150978 no 2512 0.220832742667113 3808 5337942
SGTC_956 1185-0240 191 µM -0.769414940265483 0.252893451101154 no 2513 0.220823511073538 3804 1416193
SGTC_1903 st060211 78.3 µM -0.770988841108243 0.252443665244265 no 2514 0.220356772930613 3826 688960
SGTC_836 0330-0104 1.35 µM -0.77240464111404 0.252039421573103 no 2515 0.219937402954443 3796 46494820
SGTC_1225 1216-0074 20.6 µM -0.772416681779532 0.252035985149655 no 2516 0.219933838389312 3792 4241466
SGTC_2355 9061122 103.12 µM -0.773174976133625 0.25181961664943 no 2517 0.219709416794919 3824 5302957
SGTC_1038 k292-0204 154 µM -0.773531026497447 0.251718056588856 no 2518 0.219604087011292 3757 4454212
SGTC_787 4152-0075 138 µM -0.774335055986807 0.251488794239238 no 2519 0.219366339026162 3801 9566539
SGTC_354 2783-3500 4.88 µM -0.778466431461921 0.250312509023905 no 2520 0.218147044391498 3815 6740761
SGTC_1199 1638-0010 4.46 µM -0.77919958047371 0.250104072003394 no 2521 0.217931078604002 3785 3111136
SGTC_1326 1431-2094 10.8 µM -0.779934198682238 0.249895309671323 no 2522 0.217714803741483 3785 616278
SGTC_632 0781-2353 4.65 µM -0.78180046189193 0.249365374956639 no 2523 0.21716592478158 3864 6811515 YHR007C ERG11
SGTC_790 1575-0012 79.1 µM -0.78295722009554 0.2490372078479 no 2524 0.216826117091743 3909 378741 YLR208W SEC13
SGTC_3019 9081971 49.47 µM -0.783376575139573 0.248918295479585 no 2525 0.216703003899938 3813 16451803
SGTC_1129 3453-1384 223 µM -0.783866195533932 0.248779496908088 no 2526 0.216559313553731 3957 1084452
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.785437033333427 0.248334470981938 no 2527 0.216098687414796 3817 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_692 k241-0027 77.8 µM -0.786110843666465 0.248143707407706 no 2528 0.215901276032843 3836 3600480
SGTC_3123 9126162 49.47 µM -0.786370817285294 0.248070126741255 no 2529 0.215825137513536 3894 25239884
SGTC_2802 7925815 54.55 µM -0.786856601711554 0.247932665754443 no 2530 0.215682907457838 3818 1262923
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.786962628718138 0.247902669010364 no 2531 0.215651871640481 3829 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3346 9158254 43.5805 µM -0.787607922325284 0.247720146855327 no 2532 0.215463039622562 3830 17639500
SGTC_726 3448-4391 34.2 µM -0.787622901244199 0.247715910900568 no 2533 0.215458657486656 3873 1356692
SGTC_1307 1187-1599 12.2 µM -0.788379188494194 0.247502087370733 no 2534 0.215237470176739 3818 1538471
SGTC_2014 4013930 200 µM -0.790377750145348 0.246937513142386 no 2535 0.214653596153138 3780 64556
SGTC_2528 xanthyletin 44.79 µM -0.790853211125888 0.246803301594158 no 2536 0.214514827266549 3881 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3234 9132280 49.47 µM -0.791727177091082 0.246556703277868 no 2537 0.214259886099083 3850 17612295
SGTC_2435 5706476 10.6 µM -0.795090291508886 0.245608999136936 no 2538 0.213280490822923 3835 5725375
SGTC_1222 0366-0074 1.18 µM -0.796633162791475 0.245174883445198 no 2539 0.212832055746125 3884 286520
SGTC_1926 methyl fluorone black 53.6 µM -0.796664568025946 0.24516605128193 no 2540 0.212822933543039 3635 72721 Reacts with homocysteine.
SGTC_1937 st074714 47.2 µM -0.796816565805888 0.24512330702952 no 2541 0.212778786338131 3791 17250970
SGTC_2838 9002687 71.43 µM -0.797620363388564 0.244897332706772 no 2542 0.212545415144536 3822 6457060
SGTC_1137 ixabepilone 100 µM -0.79823890241571 0.244723517102041 no 2543 0.212365932969248 3809 154225 A novel microtubule stabilizer.
SGTC_2356 9061756 188.97 µM -0.798763358652331 0.244576191744821 no 2544 0.212213820310698 3842 20104043
SGTC_2190 6049624 200 µM -0.801020732098131 0.243942617109475 no 2545 0.211559821866554 3727 2265554
SGTC_2816 7982706 58.44 µM -0.803222490405568 0.243325506000436 no 2546 0.210923074227573 3903 2981853
SGTC_1482 3346-2049 8.48 µM -0.805038534088373 0.242817139012311 no 2547 0.210398721767908 3848 3826804
SGTC_1603 st002045 67.8 µM -0.805473503452827 0.242695462966517 no 2548 0.210273245274412 3839 5887985
SGTC_1215 3852-0577 11.2 µM -0.805765689899464 0.242613746801491 no 2549 0.210188982337386 3919 2884876
SGTC_2181 6316240 54.2555 µM -0.806219689945734 0.242486805580329 no 2550 0.210058093727451 3861 12779990
SGTC_1133 3473-0247 50 µM -0.806420405197909 0.242430695825017 no 2551 0.210000242613781 3857 711311
SGTC_139 0099-0334 718.624 µM -0.812737572639758 0.240668337281813 no 2552 0.208184267198414 3888 97690
SGTC_2786 7743617 45.45 µM -0.813788379786219 0.240375861856526 no 2553 0.207883096570062 3808 583674
SGTC_949 1165-0505 146 µM -0.81473480173146 0.240112606198959 no 2554 0.207612064003454 3894 6244267
SGTC_728 3030-5151 22.5 µM -0.817212424982449 0.239424178196886 no 2555 0.206903521586815 3887 3125388
SGTC_2087 5276107 200 µM -0.817730731484628 0.239280298926665 no 2556 0.206755479242542 3827 144405
SGTC_1140 3229-1848 2.98 µM -0.818967429102971 0.238937188803818 no 2557 0.206402498418699 3882 2849525
SGTC_2969 9091408 28.7 µM -0.819812229155675 0.238702961722042 no 2558 0.206161579223817 3815 4286311
SGTC_2082 5219693 150 µM -0.819950541260172 0.238664625636744 no 2559 0.206122151410778 3857 2834649
SGTC_2182 6325192 200 µM -0.821094805092367 0.23834759831272 no 2560 0.205796134423485 3783 736248
SGTC_468 gf-109203x 121 µM -0.821309762215603 0.238288068488724 no 2561 0.20573492424736 3814 2396 A protein kinase C inhibitor.
SGTC_2873 9040596 71.43 µM -0.821719863810543 0.238174518313364 no 2562 0.205618175625526 3816 6463863
SGTC_3070 9117005 49.47 µM -0.821732290911073 0.238171077922894 no 2563 0.205614638465304 3891 8779016
SGTC_504 lovastatin 124 µM -0.821748373583496 0.238166625543156 no 2564 0.205610060863097 3874 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2788 5282734 71.43 µM -0.822024955792837 0.238090062754658 no 2565 0.205531346887599 3926 743706
SGTC_1600 coumarin 106 71.1 µM -0.822675334135662 0.237910079828459 no 2566 0.205346322833263 3956 100336 A hepatotoxic, DNA x-linker.
SGTC_544 k015-0020 52.4 µM -0.822718707196935 0.237898079606623 no 2567 0.20533398728973 3870 3008304
SGTC_828 2074-0507 139 µM -0.82426619016065 0.237470147703037 no 2568 0.20489416246424 3951 X828
SGTC_1711 st032263 62.8 µM -0.825817046820402 0.237041707138907 no 2569 0.20445394125906 3877 3958979
SGTC_893 0958-0369 48.9 µM -0.825957415050722 0.237002949905256 no 2570 0.20441412458409 3865 6819948
SGTC_1968 st069590 43.6 µM -0.826155101746887 0.236948372311086 no 2571 0.204358056853758 3871 6384066
SGTC_2889 9059656 51.95 µM -0.827739333731016 0.236511245154689 no 2572 0.20390906910599 3959 3949838
SGTC_971 1315-0384 26.7 µM -0.828171871863518 0.236391974801735 no 2573 0.203786585558549 3908 6769120
SGTC_1080 nisoldipine 24.4 µM -0.82836719042365 0.236338127482114 no 2574 0.203731290799802 3855 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2282 7944268 200 µM -0.828969246747223 0.236172189239678 no 2575 0.203560904713909 3872 2970414
SGTC_3289 9119912 71.43 µM -0.829220495552741 0.236102959244807 no 2576 0.203489824712828 3889 17014829
SGTC_2040 5100729 123 µM -0.829369250532944 0.236061976034999 no 2577 0.203447747892733 3882 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_794 k038-0031 316 µM -0.829423714022813 0.236046971879812 no 2578 0.203432343653123 3872 6624242
SGTC_1895 st058434 18.3 µM -0.830671287998955 0.235703421448435 no 2579 0.203079675286145 3899 5393175
SGTC_348 k064-0012 10.7 µM -0.831454025903709 0.235488016012332 no 2580 0.202858594806426 3788 5066323
SGTC_1775 st081588 35.1725 µM -0.83163571799662 0.235438030823031 no 2581 0.202807297333692 3896 1426443 YGL099W LSG1
SGTC_2557 derrustone 83.84 µM -0.832121614865374 0.235304384834493 no 2582 0.202670151230655 3833 629853 An antioxidant.
SGTC_184 1494-0393 24.714 µM -0.833421108758547 0.234947164761065 no 2583 0.202303636933915 3865 3090647
SGTC_3236 9132701 49.47 µM -0.833824006189576 0.234836472491947 no 2584 0.202190082740664 3879 24282524
SGTC_390 dec-rvkr-cmk 16.7 µM -0.833903386122236 0.234814667003765 no 2585 0.202167714486387 3918 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3185 9108267 49.47 µM -0.834302265854731 0.234705112585834 no 2586 0.202055337670509 3850 4910486
SGTC_2124 5246320 200 µM -0.834337149161017 0.234695533046201 no 2587 0.202045511737024 3898 579342
SGTC_2269 7935389 174.42 µM -0.835565732185822 0.234358281516578 no 2588 0.201699626766191 3835 97605
SGTC_1740 st038286 13.222 µM -0.83566148072561 0.234332009384703 no 2589 0.201672685429294 3927 716786
SGTC_3197 9113331 49.47 µM -0.836621999300062 0.234068546016122 no 2590 0.201402537884789 3875 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2405 ticlatone 3.52 µM -0.837719376148022 0.233767744290954 no 2591 0.201094164295919 3766 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_659 k018-0002 107 µM -0.840097745342462 0.233116546033756 no 2592 0.200426792083613 3873 6797879 YHR007C ERG11
SGTC_916 4466-0038 42 nM -0.840228258803779 0.233080840579066 no 2593 0.200390208452432 3974 5722064 YGL116W CDC20
SGTC_2036 5160441 105 µM -0.842652102297461 0.23241828537866 no 2594 0.199711521223627 3874 134534 YIL048W NEO1
SGTC_1591 genipin 88.4 µM -0.844287105333368 0.23197195121419 no 2595 0.199254494946453 3941 442424 A DNA cross-linking agent.
SGTC_1655 st012546 55.1 µM -0.844777210155269 0.231838252128381 no 2596 0.199117620580033 3868 720985 YLR208W SEC13
SGTC_2875 9039966 71.43 µM -0.8455422299491 0.231629642903304 no 2597 0.198904082390276 3935 6463691
SGTC_2914 7968218 45.32 µM -0.846083087069119 0.231482222565957 no 2598 0.198753197523068 3876 2977111
SGTC_2431 5490079 200 µM -0.846676209780039 0.231320616456602 no 2599 0.198587811294457 3963 5722345
SGTC_2170 morpholine 200 µM -0.847035151752964 0.23122284734188 no 2600 0.198487764308684 3937 121171 Reacts with secondary amines.
SGTC_2055 5235184 200 µM -0.848377507140989 0.230857419108941 no 2601 0.19811388257125 3950 2836034
SGTC_76 0433-0009 400.328 µM -0.848752373843551 0.230755427111285 no 2602 0.198009548211573 4008 2841569
SGTC_2934 9036370 36.88 µM -0.849613318683682 0.230521280531999 no 2603 0.19777005234875 3926 6462800
SGTC_2584 androsterone 48.74 µM -0.854142719519935 0.229291632918912 no 2604 0.196512958210992 3894 2754130 A steroid.
SGTC_662 k832-1615 104 µM -0.854348931811746 0.229235737798517 no 2605 0.196455841331722 3954 5878478
SGTC_1009 4106-0057 9.87 µM -0.857335044544746 0.228427190330466 no 2606 0.195629873073674 3861 2928005
SGTC_2299 7976368 114.88 µM -0.857531493147272 0.228374054327544 no 2607 0.195575608782286 3964 2979718
SGTC_959 1222-0044 107 µM -0.857664014297761 0.228338213535777 no 2608 0.195539008104022 3876 6083612
SGTC_2031 5180455 200 µM -0.858059033400186 0.228231398045624 no 2609 0.19542993346688 3874 29949
SGTC_1250 0485-0349 40.2 µM -0.858264265252651 0.228175913234873 no 2610 0.195373278419233 3927 6842794 YDL195W SEC31
SGTC_470 aa-861 153 µM -0.859906838049 0.227732113986379 no 2611 0.194920199414051 3923 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2719 novobiocin 32.65 µM -0.860046523878298 0.227694395338315 no 2612 0.194881698678547 3913 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_985 1493-0307 8.71 µM -0.861472824866452 0.227309459936579 no 2613 0.194488840967989 3944 3278274
SGTC_1208 2323-2347 50.3 µM -0.862722037434398 0.226972619245104 no 2614 0.194145156447202 3928 5412760
SGTC_1885 st057546 99.9 µM -0.86390410379465 0.226654143385724 no 2615 0.193820286135506 3989 702008
SGTC_1588 farnesol 29.9 µM -0.865267500691007 0.226287126320955 no 2616 0.193445992083035 3910 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2311 7694451 200 µM -0.867472539159703 0.225694256309819 no 2617 0.19284157581599 3892 2163142
SGTC_2950 9072895 21.46 µM -0.867690729338267 0.225635639204513 no 2618 0.192781831169908 3882 17332245
SGTC_2716 st080858 38.6235 µM -0.867837373626469 0.225596247846374 no 2619 0.19274168351268 3914 5296050
SGTC_373 0844-0104 25.9 µM -0.868004735382569 0.225551296150023 no 2620 0.192695870156793 3984 5375804
SGTC_389 tpck 16.7 µM -0.868300531812264 0.225471860581305 no 2621 0.192614915561263 3936 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2700 st077718 96.8 µM -0.868364248394502 0.225454751687539 no 2622 0.192597480106845 3918 904970
SGTC_3199 9111318 49.47 µM -0.86920437669652 0.225229232905997 no 2623 0.192367676976034 3891 8548020
SGTC_2484 5809818 12.04 µM -0.870061086367853 0.22499939476135 no 2624 0.192133511037417 3914 2870548
SGTC_1366 1683-0113 21.9 µM -0.87054127614828 0.2248706275586 no 2625 0.192002336236345 3931 708623
SGTC_1123 mangostin 811.285 nM -0.872569070807928 0.224327317159583 no 2626 0.191449002499264 3959 5281650 An antioxidant.
SGTC_637 1181-0519 7.26 µM -0.873842990138202 0.223986375306961 no 2627 0.191101882486244 3953 6252091 YGR060W ERG25
SGTC_1244 0416-0015 52.5 µM -0.874912439513612 0.223700383659964 no 2628 0.190810775033024 3916 96201
SGTC_2366 9070441 60.58 µM -0.875368805553878 0.223578405698383 no 2629 0.190686633648041 3948 6837235
SGTC_1981 st071826 47 µM -0.876178201385994 0.223362162653458 no 2630 0.190466582517957 3961 11838600
SGTC_2012 4023501 200 µM -0.87640972942907 0.22330032813074 no 2631 0.190403665485586 3964 3477460
SGTC_2060 5238662 140 µM -0.877488625690904 0.22301231428229 no 2632 0.190110647103853 3935 790130
SGTC_1808 st050063 61.5 µM -0.878701910969716 0.222688677860467 no 2633 0.189781461127599 3902 4011993
SGTC_660 4031-1742 102 µM -0.879389160569925 0.222505477062629 no 2634 0.189595153637619 3872 6738706
SGTC_96 0929-0093 37.281 µM -0.881637044640645 0.221906857053133 no 2635 0.188986557800542 3921 6991579
SGTC_1941 st076221 61.8 µM -0.882585335480731 0.221654599720967 no 2636 0.188730177310259 3875 2828568
SGTC_375 3970-0961 9.27 µM -0.885825274534671 0.220793972425115 no 2637 0.187855844005287 3911 2898222
SGTC_1678 st019265 80.2 µM -0.886196640717594 0.220695448546549 no 2638 0.18775578677263 3969 5367020
SGTC_1343 1487-0095 224 µM -0.887973613557096 0.220224364257001 no 2639 0.187277472509391 3954 4560101 YGL055W OLE1
SGTC_495 decylubiquinone 155 µM -0.891424818073424 0.219311082262766 no 2640 0.186350654151394 4005 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2315 7733312 200 µM -0.892190818951474 0.219108673298117 no 2641 0.186145331185004 3902 726316
SGTC_197 4544-0043 41.561 µM -0.892579662605521 0.219005965914251 no 2642 0.186041157130447 3947 896523
SGTC_153 4077-0274 519.67 µM -0.893547789249661 0.218750369697796 no 2643 0.185781945986015 3963 3121976
SGTC_2286 7945697 125 µM -0.894018561946002 0.218626142524089 no 2644 0.185655979906315 3987 1245733
SGTC_53 0973-0023 39.979 µM -0.896240105650385 0.218040471386392 no 2645 0.185062270040076 3859 674768
SGTC_1241 0364-0022 50.8 µM -0.896533468838104 0.217963198975558 no 2646 0.184983956679636 3987 4563895
SGTC_2138 5575593 77.673 µM -0.897325678318167 0.217754608430986 no 2647 0.184772579105843 3937 762213
SGTC_2134 5324836 1.464 µM -0.897533233706433 0.217699977672325 no 2648 0.184717223945406 3937 699272
SGTC_1992 st073643 23.3 µM -0.898210485225651 0.21752177296559 no 2649 0.184536672229895 3911 3161292
SGTC_2596 sinensetin 100 µM -0.899621284314946 0.217150820921882 no 2650 0.184160913177542 3999 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_846 0335-0850 148 µM -0.900326632066586 0.216965495639813 no 2651 0.183973226146697 3956 6819598
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.900561181134705 0.216903889740662 no 2652 0.183910841034296 4004 5024745
SGTC_3012 9080433 71.4286 µM -0.900974317058643 0.216795401391175 no 2653 0.18380098762338 3944 17688859
SGTC_244 nsc-207895 1.295 µM -0.90108295581639 0.216766878365129 no 2654 0.183772107216747 3778 42640
SGTC_1264 0783-0040 158 µM -0.902469438485252 0.216403048973191 no 2655 0.18340377449605 3870 2855798
SGTC_702 1488-0190 94 µM -0.902552276374944 0.216381322529352 no 2656 0.183381782378311 4005 949357
SGTC_2753 fluvastatin 17.09 µM -0.903008329213928 0.216261733130661 no 2657 0.183260737181235 4025 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_928 2764-0428 58.7 µM -0.905167080935425 0.215696169514183 no 2658 0.18268843933331 4015 662578
SGTC_2378 9074213 121.43 µM -0.905213245640374 0.215684084360713 no 2659 0.182676212996317 3944 657714
SGTC_1953 st076800 12.1 µM -0.906351622845874 0.21538620031866 no 2660 0.182374884936397 3996 297591
SGTC_555 4296-0685 37 µM -0.907282839205091 0.215142702526893 no 2661 0.182128623342725 3926 2908540 YHR072W ERG7
SGTC_3057 9095946 49.47 µM -0.907695786845469 0.215034774662167 no 2662 0.182019485265391 3999 24540043
SGTC_1974 st069448 26.9 µM -0.914786613150323 0.213186428951166 no 2663 0.180151831956108 3965 6323587 YNR016C ACC1
SGTC_957 1187-1561 14.1 µM -0.917632621387627 0.21244718168923 no 2664 0.17940561673838 3951 1538454
SGTC_2291 7917025 104.35 µM -0.92010542273837 0.211806092098079 no 2665 0.178758835432808 3933 2964612
SGTC_1034 k072-0165 12.7 µM -0.920249726329375 0.211768715456499 no 2666 0.178721137041092 4047 5835461
SGTC_2891 9063876 19.48 µM -0.921623671061041 0.211413037982928 no 2667 0.178362453499171 3983 6472478
SGTC_450 aminopyrene 156 nM -0.92287430253087 0.211089587385679 no 2668 0.178036356872319 3889 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1350 1495-0454 146 µM -0.923794024875745 0.210851904946208 no 2669 0.177796783362979 4055 1069057
SGTC_259 usnic acid 108.925 µM -0.923834841844326 0.210841360317821 no 2670 0.17778615588611 4077 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.924348766494258 0.210708619829571 no 2671 0.177652380082258 4016 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_69 0096-0274 206.684 µM -0.925058519470897 0.210525379893467 no 2672 0.177467734163337 4160 6741392
SGTC_1736 st036774 51 µM -0.925114410320521 0.21051095428908 no 2673 0.177453199016186 4076 1272247
SGTC_1295 1013-0063 9.78 µM -0.925931031483436 0.210300247964588 no 2674 0.177240911703898 4010 6826038
SGTC_3245 9134821 49.47 µM -0.927727925624931 0.209837045813399 no 2675 0.176774359470248 3995 17014901
SGTC_52 0329-0193 875 nM -0.929884511776191 0.209281915071297 no 2676 0.176215441505334 4116 3739292
SGTC_3098 9119039 49.47 µM -0.930336888869528 0.209165577641049 no 2677 0.176098341933108 4001 17161528
SGTC_201 4262-0159 12.803 µM -0.931492352341358 0.208868600968106 no 2678 0.175799469373429 4036 1341029
SGTC_2878 9043973 25.97 µM -0.93183921251506 0.208779499634221 no 2679 0.175709813147727 4079 6465167
SGTC_1196 1588-0294 184 µM -0.932608535922752 0.208581956026468 no 2680 0.175511062259022 4017 6144269
SGTC_3267 9137951 49.47 µM -0.932842707358683 0.20852184835918 no 2681 0.175450593527133 4037 16643986
SGTC_1467 k284-1082 293 µM -0.936813213447517 0.207504245254742 no 2682 0.174427323619948 3974 3334705
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.937156693342517 0.207416352759466 no 2683 0.174338981266654 4055 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_276 colchicine 750 µM -0.937840903772872 0.207241336895208 no 2684 0.174163088420174 4098 2833 A microtubule depolymerizer.
SGTC_3143 9086658 49.47 µM -0.9384666670297 0.207081347864972 no 2685 0.174002319618594 4079 25236626
SGTC_1042 0350-0096 82 µM -0.939651253428743 0.206778684560849 no 2686 0.173698238483731 4007 3122515
SGTC_2275 7947463 200 µM -0.943126791851181 0.205892192845246 no 2687 0.172808026648732 4010 1225414
SGTC_1456 k015-0012 13 µM -0.94436139315911 0.20557783151401 no 2688 0.172492501505171 4009 2989616
SGTC_500 h-89 112 µM -0.94507398365103 0.205396517365503 no 2689 0.172310553198144 4058 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2146 5545642 200 µM -0.945792071312258 0.205213900607693 no 2690 0.172127325192053 3967 825326
SGTC_1664 st014217 9.02 µM -0.946206244549645 0.205108616159015 no 2691 0.172021700877445 4063 3982782
SGTC_3151 9099821 49.47 µM -0.947131070940893 0.204873637593445 no 2692 0.17178599689075 4005 17174189
SGTC_1227 3909-8010 46.6 µM -0.949471407138182 0.204279723837275 no 2693 0.171190453830305 4015 15982272
SGTC_1114 scopoletin 1.73284 µM -0.949640805042522 0.204236775074353 no 2694 0.171147398610281 4060 5280460 A coumarin with genotoxic properties.
SGTC_3102 9121669 49.47 µM -0.952399417479718 0.20353811975652 no 2695 0.170447227392032 4055 41905072
SGTC_2142 5622915 118.518 µM -0.953000493428133 0.203386078624351 no 2696 0.170294910348774 4041 5322196
SGTC_810 3825-7150 143 µM -0.95408068556752 0.203113016243449 no 2697 0.17002140098842 4101 22330411 YGL099W LSG1
SGTC_2679 rapamycin 1 nM -0.95443115845908 0.20302446705225 no 2698 0.169932720255873 3982 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_24 0417-1663 219 µM -0.955493868824058 0.202756107520327 no 2699 0.169664002220777 4039 4329390
SGTC_155 k072-0202 43.6 µM -0.955536198037427 0.202745422782633 no 2700 0.16965330445998 3932 5857737
SGTC_3099 9120367 49.47 µM -0.957372036433188 0.202282344342262 no 2701 0.169189753760409 4058 24824940
SGTC_1053 3366-3204 134 µM -0.957766887103854 0.202182828528626 no 2702 0.169090160004228 4066 3632071 YPR165W RHO1
SGTC_7 0192-1582 4.227 µM -0.958264911911982 0.202057351099307 no 2703 0.168964596187973 4071 252616
SGTC_1951 sophoraflavanone G 9.2 µM -0.959037122161652 0.201862884782085 no 2704 0.168770022210893 4012 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2698 st077697 67.5 µM -0.959794117012648 0.201672358978389 no 2705 0.168579421875497 4019 3154499
SGTC_2217 6934799 96.0675 µM -0.959870557917031 0.201653125781656 no 2706 0.168560182858365 4001 675606
SGTC_1552 6-methylflavone 10.6 µM -0.959958978024596 0.201630879883689 no 2707 0.168537930618073 3941 689013
SGTC_717 1532-0246 73.2 µM -0.960855229108489 0.201405472186952 no 2708 0.168312482250705 4026 9561992
SGTC_2771 fluoxetine 41.05 µM -0.961893964816999 0.201144418556397 no 2709 0.16805143524404 4041 3386 A selective serotonin reuptake inhibitor.
SGTC_1965 Pectolinarigenin 58.4 µM -0.962217263604936 0.201063208974097 no 2710 0.16797023949454 4017 5320438 An anti-inflammatory.
SGTC_3333 9141820 12.094 µM -0.963307657133182 0.200789457535207 no 2711 0.167696575890187 4031 1939433
SGTC_895 0964-0006 13.7 µM -0.964829383848916 0.200407790827329 no 2712 0.167315137871486 4031 6738897
SGTC_3209 9113616 49.47 µM -0.97076325519126 0.198923675022698 no 2713 0.165833092182048 4114 16649353
SGTC_2798 7813637 45.45 µM -0.970907469286645 0.198887688395527 no 2714 0.165797179166302 4079 956368
SGTC_2238 6671620 73.2395 µM -0.97364204690077 0.198206055376558 no 2715 0.165117150731742 3985 729941
SGTC_634 1611-4317 11.2 µM -0.974374256102175 0.19802378127567 no 2716 0.164935373525904 4057 2843522
SGTC_1747 st037496 66.6 µM -0.974712387730026 0.197939641917046 no 2717 0.164851473210345 4055 723305
SGTC_1934 st074720 32.6 µM -0.977374845267643 0.197277881076701 no 2718 0.164191805826751 4010 17250992
SGTC_1949 st076024 69.1 µM -0.979363353346438 0.196784506299416 no 2719 0.163700238781423 3993 2921930
SGTC_1570 verbenone 133 µM -0.981233268117483 0.196321238434191 no 2720 0.16323886099352 4084 29025 A natural terpanoid with antifungal properties.
SGTC_352 k048-0007 5.11 µM -0.982466083494149 0.196016172685385 no 2721 0.162935142024915 4052 6811911
SGTC_1234 0326-0494 15.5 µM -0.982631062092684 0.195975369811181 no 2722 0.16289452544411 4152 1547813
SGTC_1453 4237-0541 195 µM -0.985392149553879 0.195293256512367 no 2723 0.162215742147848 4065 739892
SGTC_2227 7312221 64.1025 µM -0.988812226419401 0.194450345948009 no 2724 0.161377510581352 4153 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_165 k038-0023 64.381 µM -0.991681225412597 0.193744964663845 no 2725 0.160676526179083 4090 46368543
SGTC_221 trifluoperazine 10.304 µM -0.992114443964274 0.193638587892388 no 2726 0.160570850671638 4055 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.992630109869779 0.19351201262119 no 2727 0.16044512288021 4140 165506
SGTC_160 3453-0671 289.699 µM -0.997919195553563 0.192216669933982 no 2728 0.159159271526593 4132 5322268
SGTC_2837 9008476 45.46 µM -0.998497327892621 0.192075402621248 no 2729 0.159019129777678 4118 2992805
SGTC_2253 7938677 135.83 µM -1.00310143234613 0.190952653230793 no 2730 0.157905961841748 4167 2301972
SGTC_2857 9024691 58.44 µM -1.00371977237339 0.190802173071126 no 2731 0.157756851950314 4192 16478292
SGTC_171 k064-0041 9.68 µM -1.00384358785129 0.190772049896261 no 2732 0.157727005526961 4117 53325
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.00423408364026 0.190677064954997 no 2733 0.157632898599634 4080 390807
SGTC_3042 9091578 49.47 µM -1.00494440515342 0.190504359432976 no 2734 0.157461810368498 4076 25236497
SGTC_2001 4023502 57.655 µM -1.00667963275272 0.190082865277939 no 2735 0.157044376378312 4133 108941 YCR052W RSC6
SGTC_1964 st076914 61 µM -1.00866708256681 0.189600810018 no 2736 0.156567161786899 4136 24208661
SGTC_1345 1488-0192 31.4 µM -1.01062088756318 0.18912764911003 no 2737 0.156098957359108 4153 658348
SGTC_3331 9141060 1.957 µM -1.01290941917363 0.188574351726801 no 2738 0.155551714448408 4062 4906567 YPR165W RHO1
SGTC_2444 5485484 36.41 µM -1.01394087552077 0.188325303547689 no 2739 0.155305482686207 4192 6790631
SGTC_570 0987-0065 62.6 µM -1.01485065730137 0.188105802551887 no 2740 0.15508851100329 3879 3104428
SGTC_2673 kobusone 100 µM -1.0164748477839 0.187714330550124 no 2741 0.154701659517063 4171 6710676 An epoxy ketone and protein crosslinker.
SGTC_2768 sulfasalazine 50.2 µM -1.0205685974452 0.186729865721876 no 2742 0.153729436849744 4041 5384001 An antioxidant and salicylic acid derivative.
SGTC_1081 sertraline 6 µM -1.02216050663151 0.186347908063819 no 2743 0.153352469711089 4104 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_301 4119-0100 24.5 µM -1.02245578348206 0.186277113524067 no 2744 0.153282614974942 4126 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1977 st070720 65.3 µM -1.02288029895922 0.186175362392096 no 2745 0.153182222729195 4141 682188
SGTC_1411 3909-8223 150 µM -1.02335405992677 0.186061848402911 no 2746 0.153070236042835 4138 X1411
SGTC_2662 daunorubicin 22.37 µM -1.02797519410816 0.18495686769578 no 2747 0.151980748198466 4000 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_75 0159-0059 199.013 µM -1.0283409288692 0.184869589643785 no 2748 0.151894742346378 4229 5377270
SGTC_235 0330-0087 5 mM -1.02862091713078 0.184802791228455 no 2749 0.151828922418887 4148 46494818 YHR062C RPP1
SGTC_2496 diffractaic acid 79.83 µM -1.03085177685912 0.184271098265457 no 2750 0.151305166733827 4152 94870 An apoptosis inducer which activates caspases.
SGTC_315 k915-0449 187 µM -1.03162770401428 0.184086390663389 no 2751 0.151123278497774 4137 20970215 YNL149C PGA2
SGTC_228 caffeine 993.056 µM -1.03197358733218 0.184004091120917 no 2752 0.151042245482502 4126 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_844 0330-0132 15.3 µM -1.03477943381333 0.183337314448899 no 2753 0.150385964823692 4176 2828079
SGTC_1357 1503-1303 39.5 µM -1.03485685689397 0.183318937141838 no 2754 0.150367882730802 4081 292895
SGTC_3229 9132204 49.47 µM -1.03586806913482 0.18307901913457 no 2755 0.150131848017721 4175 17682924
SGTC_318 1488-0629 67.2 µM -1.0360644718447 0.183032443784474 no 2756 0.150086032831927 4163 3662576
SGTC_3103 9120822 49.47 µM -1.03756916005907 0.182675864185412 no 2757 0.14973534098526 4155 17141819
SGTC_1040 k898-0338 155 µM -1.03885939910614 0.182370450225919 no 2758 0.149435065656882 4146 20969351
SGTC_1713 st033146 12.748 µM -1.0389001090358 0.182360818926695 no 2759 0.149425597843985 4139 674619
SGTC_2824 7998404 51.95 µM -1.04465424525068 0.18100268320624 no 2760 0.148091399421414 4103 837851
SGTC_2436 5633522 8.09 µM -1.04665436954878 0.180532086638514 no 2761 0.147629508102146 4136 5724242
SGTC_430 0958-0115 16.4 µM -1.04692819498908 0.180467719761727 no 2762 0.147566348411151 4097 6833180
SGTC_410 α-linolenic acid 100 µM -1.04819948159555 0.180169072918308 no 2763 0.147273354678563 4208 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3303 9125618 40.5795 µM -1.04925794930269 0.179920657662958 no 2764 0.147029707035906 4160 22695467
SGTC_1704 st028805 70.8 µM -1.05019891711428 0.179699999547547 no 2765 0.146813333659206 4177 2876101
SGTC_842 0271-0008 11.1 µM -1.05376964979896 0.178864206099145 no 2766 0.145994196005835 4193 1221709
SGTC_1383 3049-0032 20.7 µM -1.05699406515517 0.178111580250005 no 2767 0.145257148011367 4207 712864
SGTC_1680 diphenhydramine 100 µM -1.05728099606307 0.178044703235746 no 2768 0.145191681873121 4140 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1569 carminic acid 40.6 µM -1.05824605341592 0.177819886692604 no 2769 0.144971640152656 4243 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1118 chelidonine 707.474 nM -1.05845988677037 0.177770097031534 no 2770 0.144922914630753 4145 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1878 temozolomide 1 mM -1.05881617685226 0.177687156815063 no 2771 0.144841752443698 4067 5394 DNA alkylating agent.
SGTC_1387 3342-1166 1.8 µM -1.05922719013505 0.177591508003655 no 2772 0.144748162444013 4119 3418228
SGTC_2806 7952793 58.44 µM -1.05940357750066 0.177550470046213 no 2773 0.144708010556804 4219 2972490
SGTC_1785 bathophenanthroline 24 µM -1.0601155850652 0.177384876534456 no 2774 0.144546009182259 4062 72812 An iron chelator.
SGTC_176 1486-1328 72.834 µM -1.06212090855175 0.176919017318214 no 2775 0.144090399634548 4227 22310231
SGTC_649 1123-0311 367 µM -1.0624080922072 0.176852364672416 no 2776 0.144025230858555 4049 693629 YIL048W NEO1
SGTC_2671 danthron 100 µM -1.0638873560256 0.176509292822583 no 2777 0.143689865768309 4139 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_505 gw-5074 63.9 µM -1.06470308267008 0.176320289142906 no 2778 0.143505157321668 4180 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1001 4048-4355 44.4 µM -1.06489658343876 0.176275473856647 no 2779 0.14346136565197 4142 21824233
SGTC_3269 9137823 49.47 µM -1.066208445655 0.175971833237743 no 2780 0.143164712581907 4068 17682936
SGTC_1795 st049545 62.3 µM -1.06663428422389 0.175873340863062 no 2781 0.143068506311913 4117 5291882
SGTC_1841 st054148 70 µM -1.06824263041522 0.175501660856368 no 2782 0.142705539729185 4190 675442
SGTC_2810 7959871 45.46 µM -1.06859137600998 0.17542113338521 no 2783 0.142626918109386 4131 2974535
SGTC_1957 st077035 62.4 µM -1.07339782107788 0.174313682915377 no 2784 0.141546330870562 4169 705593
SGTC_2007 4011539 71.82 µM -1.07382571135372 0.174215308738394 no 2785 0.141450401983853 4125 45595301
SGTC_2051 5263410 176 µM -1.07403834254936 0.174166436857072 no 2786 0.141402748503997 4160 227584
SGTC_954 1189-0853 2.85 µM -1.0743145183146 0.174102972684577 no 2787 0.141340870086042 4111 2828194
SGTC_1406 3909-7906 11.9 µM -1.0746109307224 0.174034874563413 no 2788 0.14127447798107 4176 X1406
SGTC_360 0957-0399 1.01 µM -1.08350860012024 0.171998600838014 no 2789 0.139291367826696 4188 6752301 YPR165W RHO1
SGTC_2332 7982454 138.89 µM -1.08411533298413 0.171860303304967 no 2790 0.139156832625759 4111 2981748
SGTC_3309 9129340 25.759 µM -1.08459657607609 0.171750660184386 no 2791 0.139050186077255 4200 17158987
SGTC_2865 9030313 51.95 µM -1.09007837680426 0.170504878642099 no 2792 0.13783931021818 4138 42562754
SGTC_3263 9137018 49.47 µM -1.09134391967706 0.170218098419831 no 2793 0.137560789476621 4154 43844957
SGTC_580 1123-0028 41 µM -1.09189048920932 0.17009433783506 no 2794 0.137440619292376 4224 1677248 YPR107C YTH1
SGTC_2046 4110841 106 µM -1.09328213789097 0.169779485089126 no 2795 0.137134971485455 4178 44119630 YMR134W ERG29
SGTC_617 3770-0098 35 µM -1.09503996923475 0.169382320123353 no 2796 0.136749563134569 4105 5962639
SGTC_1873 rapamycin 2 nM -1.09560610309735 0.16925453471094 no 2797 0.136625594851735 4149 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_252 miconazole 1.30953 nM -1.09908192601727 0.168471343105079 no 2798 0.135866166358453 4091 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_185 k048-0037 25.491 µM -1.0999044282821 0.168286353847899 no 2799 0.135686882547614 4243 6827589
SGTC_423 5-fluorouracil 457 µM -1.10070334710091 0.168106793891903 no 2800 0.13551289452055 4122 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1175 0741-0056 27.6 µM -1.10209100306495 0.167795206228319 no 2801 0.135211055189 4284 765927
SGTC_1423 4048-0112 5.59 µM -1.10537284449581 0.167059774242873 no 2802 0.134499032739838 4230 X1423
SGTC_3156 9099931 49.47 µM -1.10676871823618 0.166747602123146 no 2803 0.134196968100021 4230 18111053
SGTC_2367 9070478 135.38 µM -1.1083294549125 0.166399006169318 no 2804 0.133859779567567 4149 572802
SGTC_3100 9120536 49.47 µM -1.10846208177583 0.166369405206296 no 2805 0.133831153134509 4049 16421196
SGTC_3000 9075062 71.4286 µM -1.11091613296501 0.165822299610256 no 2806 0.13330222527459 4154 17057871
SGTC_1649 st011737 51.3 µM -1.11157549676524 0.165675499646543 no 2807 0.133160356391629 4210 1761035
SGTC_329 k048-0121 21.3 µM -1.11216589590511 0.165544125223928 no 2808 0.13303341416634 4211 6832902
SGTC_156 3474-0145 5.642 µM -1.11368025600067 0.165207461028794 no 2809 0.132708191247072 4024 2265471
SGTC_2074 5212007 75.395 µM -1.1144404449204 0.165038627189528 no 2810 0.132545140216737 4104 758611
SGTC_1390 3413-2614 145 µM -1.11523581974056 0.16486209838059 no 2811 0.132374690060024 4232 3421432
SGTC_222 nsc-310342 10.666 µM -1.11817134859183 0.164211633867985 no 2812 0.131746909290815 4212 432556
SGTC_229 benomyl 22.8748 µM -1.11845500037515 0.164148869636467 no 2813 0.13168635764442 4226 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2168 5727979 200 µM -1.11927912802407 0.163966601452046 no 2814 0.131510538627696 4115 695210
SGTC_2350 9023895 38.85 µM -1.12351159654994 0.163032597417234 no 2815 0.130610139124368 4229 2997209
SGTC_1697 st025554 27.742 µM -1.12374065551758 0.162982148452687 no 2816 0.130561531854629 4207 1269519
SGTC_2752 diclazuril 33.15 µM -1.12399474764161 0.162926197948864 no 2817 0.130507627080034 4167 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_79 0052-0007 94.094 µM -1.12484251462548 0.162739611953351 no 2818 0.130327887565632 4211 2801472
SGTC_1205 4161-2785 76 µM -1.12535730440663 0.162626379134549 no 2819 0.130218827892547 4277 3498106
SGTC_1982 st072467 71.9 µM -1.12592507706862 0.162501551690614 no 2820 0.130098616893892 4189 3163533
SGTC_2085 5307070 144.047 µM -1.12621949756051 0.162436846539319 no 2821 0.130036311309452 4160 2840351
SGTC_1464 k208-0027 110 µM -1.12671998341517 0.162326892634894 no 2822 0.129930445349261 4229 X1464
SGTC_370 0180-0345 38.7 µM -1.12963971514824 0.161686410128997 no 2823 0.12931403450491 4071 3989527
SGTC_2155 5570423 76 µM -1.13061573439711 0.161472674981516 no 2824 0.129108431027057 4182 797402
SGTC_1636 st007707 68.9 µM -1.13071342407571 0.161451292397043 no 2825 0.129087864678368 4254 403051
SGTC_1660 st012960 28.1 µM -1.13344074743376 0.160855073768659 no 2826 0.12851460532252 4241 24207266
SGTC_3087 9117406 49.47 µM -1.13514501795914 0.160483234831518 no 2827 0.128157281018719 4254 42546093
SGTC_1724 st037281 8.293 µM -1.13895132049424 0.159654802392911 no 2828 0.127361729261859 4198 574124 YDL195W SEC31
SGTC_2184 6075246 200 µM -1.14111609159896 0.159184895875353 no 2829 0.126910807877886 4232 2267320
SGTC_2220 6782180 200 µM -1.14558188113822 0.15821837260673 no 2830 0.125984098900547 4152 833803
SGTC_2477 5967686 25.23 µM -1.14610926715879 0.15810448612917 no 2831 0.125874971807113 4219 776118
SGTC_2959 9079155 11 µM -1.1505433802656 0.157149089259501 no 2832 0.124960068893956 4272 16189457
SGTC_1607 st000305 50.6 µM -1.15106089169357 0.157037831507848 no 2833 0.12485359282021 4260 5457690
SGTC_2897 9048598 12.99 µM -1.15290511462403 0.156641770653694 no 2834 0.124474666270822 4221 6467404
SGTC_2131 toluylene red 5.2905 µM -1.15378099810092 0.156453898539432 no 2835 0.124294983225511 4212 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_80 0159-0065 512.242 µM -1.15388929897481 0.156430678918849 no 2836 0.124272778460298 4159 1548079
SGTC_1602 st001878 87.6 µM -1.15640705643024 0.155891513392853 no 2837 0.123757348315558 4231 595405 YLR310C CDC25
SGTC_2687 chenodiol 100 µM -1.15650172954033 0.155871263533508 no 2838 0.123737996270592 4321 5702181 A cholesterol synthesis inhibitor.
SGTC_3025 9087895 49.47 µM -1.15767410627549 0.15562064475679 no 2839 0.123498527353439 4228 17173641
SGTC_535 2293-4129 48.2 µM -1.15804229119871 0.155541992799738 no 2840 0.123423389160904 4255 396118 YIL048W NEO1
SGTC_3318 9139014 38.6185 µM -1.15930577681623 0.155272285427402 no 2841 0.123165783936588 4251 16643984
SGTC_4 0960-0234 25.671 µM -1.15932096886899 0.155269044366115 no 2842 0.123162688805794 4256 6821112
SGTC_2724 maprotiline 69.64 µM -1.16286194575376 0.154514833061874 no 2843 0.122442759596493 4185 4011 A tricyclic antidepressant.
SGTC_521 r062-0005 13.8 µM -1.16312822441215 0.154458215031665 no 2844 0.122388741126107 4171 2832033
SGTC_3247 9135149 49.47 µM -1.16486801277916 0.154088626641678 no 2845 0.12203621157271 4271 8934436 YOR116C RPO31
SGTC_371 0195-0006 7.36 µM -1.1656986637367 0.153912375512726 no 2846 0.121868150317472 4075 3928593
SGTC_808 0711-0032 135 µM -1.16795152497227 0.15343502548098 no 2847 0.121413159384869 4237 4252555
SGTC_694 1315-0438 43.2 µM -1.17240442178673 0.152494406079516 no 2848 0.120517362532377 4272 6793154
SGTC_1685 st024049 53.0905 µM -1.17387342284095 0.152184938941993 no 2849 0.120222864615714 4277 1941139
SGTC_1005 4092-0690 4.4 µM -1.17458116063458 0.152035992294234 no 2850 0.120081162045423 4280 1529343
SGTC_1683 st010134 710 nM -1.17481171916064 0.151987491115784 no 2851 0.120035025270899 4241 3818134
SGTC_2826 7992541 19.48 µM -1.17536538688881 0.151871061420744 no 2852 0.119924282552784 4276 2985066
SGTC_1173 0443-0020 122 µM -1.17550918360023 0.151840832389871 no 2853 0.11989553261402 4252 5331295
SGTC_107 0358-0022 2.6945 µM -1.17565907916091 0.151809325511243 no 2854 0.119865568477069 4293 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3213 9129884 49.47 µM -1.17650075815202 0.151632491830169 no 2855 0.119697414820064 4255 17190742
SGTC_3026 9090633 49.47 µM -1.17731071928134 0.151462451279395 no 2856 0.119535755012097 4272 25236842
SGTC_3301 9125354 19.7965 µM -1.17732145150299 0.15146019904385 no 2857 0.119533614006828 4256 41905162
SGTC_2795 7780010 54.55 µM -1.17776672103161 0.151366775590146 no 2858 0.119444809605477 4233 953673
SGTC_2149 5554786 194.827 µM -1.17792192709806 0.151334220307519 no 2859 0.119413866304278 4300 745063 YPR165W RHO1
SGTC_2257 7960413 200 µM -1.17841089902098 0.151231686341723 no 2860 0.119316417369716 4286 2974689 YIL048W NEO1
SGTC_2424 5537928 59.2 µM -1.18143064844798 0.150599490294473 no 2861 0.118715844348148 4272 5382802
SGTC_737 1950-0117 57.9 µM -1.18157128875627 0.15057008966898 no 2862 0.118687925700955 4265 5393513
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.18242960806178 0.150390742291479 no 2863 0.118517640424031 4277 2374 Ca(2+)-ATPase inhibitor.
SGTC_2223 6903751 107.57 µM -1.18308652301203 0.150253574912516 no 2864 0.118387429228716 4227 5598863
SGTC_545 4218-0007 221 µM -1.18321557475343 0.150226638015821 no 2865 0.118361860970086 4253 2840508
SGTC_922 1866-0035 480 µM -1.18369577848184 0.150126433636029 no 2866 0.118266755332404 4193 3156169
SGTC_1726 st035556 14.5795 µM -1.18618928244926 0.14960682925798 no 2867 0.117773778890695 4346 5919439
SGTC_2666 tannic acid 100 µM -1.1901009745414 0.148794118914892 no 2868 0.117003353648045 4268 16134267 A thiamine antagonist.
SGTC_47 0149-0135 24.25 µM -1.1915845338013 0.148486661283116 no 2869 0.116712096176624 4286 5239155
SGTC_1078 idebenone 36.1 µM -1.19239412238701 0.148319058821039 no 2870 0.116553371929957 4322 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2162 5663267 200 µM -1.19286127232868 0.148222406212352 no 2871 0.116461854326731 4281 6456493
SGTC_3306 9127676 59.7925 µM -1.19435799483306 0.147913020459697 no 2872 0.116168980313618 4250 41905287
SGTC_1207 2099-0101 141 µM -1.19564937963721 0.147646427482278 no 2873 0.115916706514166 4275 5837381
SGTC_303 1348-1668 34.2 µM -1.1957634659746 0.147622891024552 no 2874 0.11589443830531 4292 5380509
SGTC_45 0kpi-0036 14.9 µM -1.19707243470176 0.147353025490617 no 2875 0.115639161512966 4313 2795021
SGTC_1043 0916-0009 19.3 µM -1.20179147095858 0.146382864028777 no 2876 0.114722165390344 4315 3101130
SGTC_827 3253-0474 693 µM -1.20267463517833 0.146201776501014 no 2877 0.114551126580831 4315 5402065
SGTC_3276 9139060 49.47 µM -1.20276619886517 0.146183010527863 no 2878 0.114533404204735 4395 4870619
SGTC_917 harmaline 728.087 nM -1.20324327328975 0.146085260323064 no 2879 0.114441096853937 4227 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3132 9126706 49.47 µM -1.20428228305885 0.145872524309289 no 2880 0.114240246029127 4349 850858
SGTC_925 2064-1272 59.6 µM -1.20502579079893 0.145720419844558 no 2881 0.114096672833526 4267 6815817
SGTC_334 1502-1024 68.5 µM -1.2072054355796 0.145275129609423 no 2882 0.113676518830276 4299 3296216
SGTC_172 1112-0046 2.638 µM -1.20908874043967 0.144891118096638 no 2883 0.113314377243736 4273 2802135 YIL048W NEO1
SGTC_1337 1486-1011 40.3 µM -1.20919122603449 0.144870240602188 no 2884 0.113294693876666 4260 X1337
SGTC_2189 6047310 154.431 µM -1.21453839134515 0.143783770940625 no 2885 0.112271099389235 4277 711535
SGTC_2096 5468907 200 µM -1.21458052815555 0.143775231215863 no 2886 0.112263059576098 4297 759785
SGTC_1917 st066507 28.5 µM -1.2151033958327 0.143669291863451 no 2887 0.112163329290253 4254 3156428
SGTC_2894 9048625 32.47 µM -1.21573571010694 0.143541247688938 no 2888 0.112042808090406 4316 4092861
SGTC_1716 st033144 30.6155 µM -1.21997341043225 0.142685098175922 no 2889 0.111237477400223 4322 674617
SGTC_1346 1488-2224 62.4 µM -1.2226600787064 0.142144098070282 no 2890 0.11072905557658 4307 3722427
SGTC_2534 helenine 20.12 µM -1.22303756980669 0.142068196073887 no 2891 0.110657753258448 4332 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2738 aclarubicin 5.55 µM -1.22368705253767 0.141937669037302 no 2892 0.110535152887288 4305 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2911 7942208 15.64 µM -1.22674873848938 0.14132345344391 no 2893 0.109958521496663 4338 1243384
SGTC_1143 3454-2408 5.08 µM -1.22755170615448 0.141162665932576 no 2894 0.109807650206269 4311 X1143
SGTC_1309 pyrazolanthrone 13.4 µM -1.2277859699126 0.141115779969647 no 2895 0.109763661904396 4274 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_722 3534-0461 190 µM -1.22921071445266 0.14083085649711 no 2896 0.109496406378122 4342 658262
SGTC_1966 st070145 16.1 µM -1.23018656153275 0.140635929870845 no 2897 0.109313625506801 4293 3748532
SGTC_2080 5212524 12.4 µM -1.2303909101685 0.140595134184391 no 2898 0.109275377791995 4260 260183
SGTC_1928 4'-methoxychalcone 40.3 µM -1.23057737104446 0.140557916577918 no 2899 0.109240486499683 4331 641818
SGTC_3129 9127257 49.47 µM -1.23095117633398 0.140483325154599 no 2900 0.109170562693461 4263 837894
SGTC_1021 4476-0760 85.3 µM -1.23097703822348 0.140478165507089 no 2901 0.109165726172816 4323 746768
SGTC_3219 9131112 49.47 µM -1.23977290480728 0.138730781916124 no 2902 0.107529701355572 4206 17612988 YMR079W SEC14
SGTC_1884 5633444 25 µM -1.2407795924716 0.138531742004004 no 2903 0.107343591041719 4298 5724239
SGTC_304 1310-0298 97 µM -1.24415017357112 0.13786673553597 no 2904 0.106722148986419 4097 1550234
SGTC_1342 1486-1464 234 µM -1.24576527549719 0.137548853395586 no 2905 0.106425290661531 4355 3253938
SGTC_1741 st038134 10.228 µM -1.24616650764372 0.137469961084448 no 2906 0.106351636094727 4379 1272587
SGTC_1151 3909-8316 15.3 µM -1.24784994886847 0.137139291048254 no 2907 0.106043006419189 4356 800431
SGTC_1048 3161-0300 24.5 µM -1.25079063233026 0.136562971657494 no 2908 0.105505436745042 4318 2165101
SGTC_2507 purpurin 79.67 µM -1.25124245815379 0.136474569190271 no 2909 0.105423016010935 4322 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2918 7977171 22.06 µM -1.25192850921323 0.136340413985874 no 2910 0.105297957661728 4316 2236483
SGTC_628 1636-0253 16 µM -1.25220039309778 0.136287272888142 no 2911 0.105248426408251 4325 4456143
SGTC_1202 1988-0068 29.6 µM -1.25370485761206 0.135993473791357 no 2912 0.104974650836582 4301 2850480
SGTC_2921 7974240 10.71 µM -1.25417774510344 0.13590121566791 no 2913 0.104888703514304 4419 2979074 YDR527W RBA50
SGTC_3155 9099265 49.47 µM -1.25488762674425 0.135762801571087 no 2914 0.104759778158221 4319 25236499
SGTC_405 ebelactone b 50 µM -1.25814141534701 0.135129607297134 no 2915 0.104170308839907 4267 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2706 st078239 82.5 µM -1.25860456671928 0.135039641947114 no 2916 0.104086598364965 4312 15434492
SGTC_2623 humulene 100 µM -1.26023883723081 0.134722519512515 no 2917 0.103791608253956 4330 6187145 An anti-inflammatory.
SGTC_1605 st000082 49.1 µM -1.26366524080991 0.134059302114536 no 2918 0.103175103056524 4304 1114022
SGTC_2208 7283366 200 µM -1.26566875283354 0.133672541731586 no 2919 0.10281584994288 4325 898663
SGTC_1650 st011916 45.8 µM -1.26667664207795 0.133478267891749 no 2920 0.102635467657142 4261 242528
SGTC_1959 st077091 55.8 µM -1.2711111579157 0.132625808365349 no 2921 0.101844553195616 4350 821356 YKL052C ASK1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.27416462142356 0.132041017244427 no 2922 0.101302540236988 4275 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1274 0865-0114 173 µM -1.27600313708856 0.131689768572173 no 2923 0.100977205072393 4342 870624
SGTC_1060 3448-7350 82 µM -1.27665640136779 0.131565117734502 no 2924 0.100861790064003 4276 570178
SGTC_2797 7859098 81.82 µM -1.28252826682066 0.130448349337745 no 2925 0.0998286978137425 4330 972681
SGTC_664 1222-0054 14.9 µM -1.28290853320731 0.130376253308099 no 2926 0.0997620614621444 4321 6813991
SGTC_1330 1469-0054 61.8 µM -1.28361431700407 0.130242514360586 no 2927 0.0996384688845555 4350 7102664
SGTC_1027 k015-0025 8.67 µM -1.28513891738186 0.129953941949582 no 2928 0.0993718720618971 4340 3598955
SGTC_3258 9138477 49.47 µM -1.28546545109278 0.129892194088854 no 2929 0.0993148411285997 4380 4970355
SGTC_1436 4092-1007 8.32 µM -1.28855353114884 0.12930923933666 no 2930 0.0987766736295713 4347 2881121
SGTC_3186 9110464 49.47 µM -1.2909894725785 0.128850673716756 no 2931 0.0983536639964088 4349 17018021
SGTC_2246 7293507 91.5585 µM -1.29694949582488 0.127733460434104 no 2932 0.0973242822937261 4428 887656
SGTC_1072 oxiconazole 14.9 nM -1.29710929766009 0.127703598366067 no 2933 0.0972967914400095 4364 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2474 5321570 43.32 µM -1.29850115643214 0.127443707794009 no 2934 0.0970575896041028 4352 2841384
SGTC_97 0535-0701 19.132 µM -1.29870717054108 0.127405271712012 no 2935 0.0970222211697376 4258 2832013 YGL099W LSG1
SGTC_1470 k295-0292 231 µM -1.29888865525985 0.127371418761812 no 2936 0.0969910717718839 4441 5045612
SGTC_837 0091-0265 12.5 µM -1.29916040832349 0.127320739454789 no 2937 0.0969444427608652 4347 759367
SGTC_1642 st009582 77.7 µM -1.30288899611425 0.126626810291532 no 2938 0.0963063306037716 4338 6739311
SGTC_3319 9138450 16.7555 µM -1.30386976854862 0.126444716675774 no 2939 0.0961389947242462 4293 2029690
SGTC_2659 sanguinarine 24.21 µM -1.30412448878855 0.126397454289444 no 2940 0.0960955702563992 4325 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1518 st038567 90.8 µM -1.30537871464021 0.126164916903314 no 2941 0.0958819613182002 4319 77966
SGTC_2057 5236571 38.335 µM -1.30551103273349 0.126140402116589 no 2942 0.0958594464223173 4330 54684039 YBR257W POP4
SGTC_1158 4092-0494 91.8 µM -1.30764504002145 0.125745489711928 no 2943 0.0954968663404376 4445 1148199
SGTC_2334 9017922 200 µM -1.31114084040735 0.125100433524142 no 2944 0.0949050925021536 4408 3163164
SGTC_2731 amoxapine 43.43 µM -1.31384865753985 0.124602369426143 no 2945 0.0944485697415794 4531 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2009 4012297 12.05 µM -1.31588476408616 0.124228771007332 no 2946 0.0941063616295868 4349 45595307
SGTC_2457 5731572 11.68 µM -1.31743642707922 0.123944588114284 no 2947 0.0938461887030679 4424 2865357
SGTC_2986 9022445 71.43 µM -1.31834546572825 0.123778311643359 no 2948 0.0936940137554264 4365 6459286
SGTC_2027 5150920 200 µM -1.31880597458181 0.123694137454767 no 2949 0.0936169931807375 4312 786715
SGTC_2665 lovastatin 100 µM -1.31929711813125 0.123604407874368 no 2950 0.0935349004533875 4399 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2732 terfenadine 20 µM -1.32050385625831 0.123384136198641 no 2951 0.0933334246887305 4451 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1712 st032288 53.4 µM -1.32184610008278 0.123139453243848 no 2952 0.0931097018743721 4200 2883011
SGTC_406 estrone 100 µM -1.32356090347312 0.122827349986535 no 2953 0.0928244584336464 4350 5870 A steroid.
SGTC_2465 5809242 33.21 µM -1.32403830558043 0.122740559089223 no 2954 0.0927451616232767 4433 2731748
SGTC_2684 capsaicin 100 µM -1.33219943637733 0.121263528795193 no 2955 0.0913973308622149 4420 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1068 loratadine 26.9 µM -1.33250063750506 0.121209256560609 no 2956 0.091347866057575 4438 3957 A H1 histamine antagonist.
SGTC_257 daunorubicin 18.5 µM -1.33331396632042 0.121062791427694 no 2957 0.0912143961521142 4416 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_489 paxilline 115 µM -1.33472971969934 0.120808138113722 no 2958 0.0909824114373752 4358 105008 A toxic potassium channel blocker.
SGTC_2813 7971799 71.43 µM -1.33490783479794 0.120776127049503 no 2959 0.0909532566000078 4404 2234054
SGTC_1715 st032160 10.2275 µM -1.33572202335778 0.120629876104125 no 2960 0.0908200740832805 4311 5289825
SGTC_547 1120-0019 610 nM -1.33942454387563 0.119966373166893 no 2961 0.0902162518367803 4346 3676939
SGTC_3097 9117246 49.47 µM -1.34123464840933 0.119642934871483 no 2962 0.0899221401040608 4418 16423892
SGTC_591 4299-0174 154 µM -1.34269405172488 0.119382609784927 no 2963 0.0896855307886794 4435 5509088
SGTC_611 3453-1652 23.7 µM -1.34443276048759 0.119072984889673 no 2964 0.0894042430064162 4412 1560575
SGTC_2119 5528445 120.635 µM -1.35116568690532 0.117879352214951 no 2965 0.0883211817628384 4435 791935
SGTC_3279 9140807 49.47 µM -1.35204965429895 0.117723270856115 no 2966 0.0881797156754827 4445 45595718
SGTC_2048 5246248 200 µM -1.35266380082792 0.11761491767849 no 2967 0.0880815299673176 4419 677046
SGTC_2464 5717415 7.67 µM -1.35476255442218 0.117245169853671 no 2968 0.0877466102487905 4360 5285744
SGTC_3010 9080089 71.4286 µM -1.35921641912742 0.116463239901723 no 2969 0.0870390099390682 4413 17027233
SGTC_2612 dictamnine 15.46 µM -1.36172333918145 0.116024750162436 no 2970 0.0866426063914075 4334 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_294 k038-0071 157 µM -1.3643454028673 0.115567375751966 no 2971 0.0862294412722507 4415 24152826
SGTC_1789 tunicamycin 25 nM -1.36465988791884 0.115512605334305 no 2972 0.086179986217126 4318 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1283 0922-0125 16.4 µM -1.36834465837245 0.114872242935502 no 2973 0.0856021091052857 4405 3360884
SGTC_1757 st041620 31.8375 µM -1.37042883706529 0.114511161447126 no 2974 0.0852765377232968 4451 5289815
SGTC_3200 9114385 49.47 µM -1.37127076066162 0.114365528515129 no 2975 0.085145283487109 4403 17018030 YLR208W SEC13
SGTC_1260 0700-1617 7.75 µM -1.37140681939234 0.114342005945282 no 2976 0.0851240864149805 4389 2853078
SGTC_135 0933-0004 26.348 µM -1.37620095524322 0.113515367912876 no 2977 0.0843797132250566 4354 21230617 YGL099W LSG1
SGTC_3353 9151644 39.2805 µM -1.37870366753113 0.113085529883271 no 2978 0.0839930691358106 4435 4909158
SGTC_1216 1165-0504 9.65 µM -1.38091758816107 0.112706260754938 no 2979 0.0836521507092097 4450 6304004
SGTC_759 3486-0358 89.3 µM -1.38187661643673 0.112542250852579 no 2980 0.0835047944652282 4418 875103
SGTC_2229 7354935 190 µM -1.38508232406029 0.111995258663317 no 2981 0.0830136480564481 4383 318112
SGTC_1236 0330-0013 258 µM -1.38626885918039 0.1117932820921 no 2982 0.0828324110190538 4438 4617066
SGTC_2022 5136654 200 µM -1.39121757150117 0.110953702670623 no 2983 0.0820797302143621 4434 1713771
SGTC_286 k060-0067 22.9 µM -1.39717226675213 0.109949451182586 no 2984 0.0811808871700246 4461 5985051
SGTC_1472 k841-0093 193 µM -1.405389136049 0.108574421447638 no 2985 0.0799527977460682 4540 X1472
SGTC_919 tnp00227 403.569 nM -1.40600311332989 0.108472175982057 no 2986 0.0798616001433908 4390 1269246 A methoxyflavone. YNL221C POP1
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.40613098817893 0.10845088973817 no 2987 0.0798426160538542 4418 442882
SGTC_2988 9073640 71.4286 µM -1.40795159830136 0.108148154122919 no 2988 0.0795727013607349 4465 9102229
SGTC_663 1486-0733 13.9 µM -1.41001758758561 0.107805353647626 no 2989 0.0792672448807583 4453 722445 YPR165W RHO1
SGTC_898 1000-0849 28.3 µM -1.41059363038529 0.107709913096198 no 2990 0.0791822354255516 4455 6751807
SGTC_309 k408-0051 1.48 µM -1.41103622535442 0.10763662395689 no 2991 0.0791169664279084 4369 3640463
SGTC_1088 bifonazole 369 nM -1.41119677048022 0.10761004823066 no 2992 0.0790933010852404 4424 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1102 cgs 12066b 26.1 µM -1.41945981467564 0.106248608554422 no 2993 0.0778825022949367 4457 6438352 A 5-HT1B full agonist.
SGTC_416 estradiol valerate 100 µM -1.42238393387626 0.105769816306523 no 2994 0.077457412287048 4449 13791 A steroid.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.42290586026533 0.105684520918702 no 2995 0.0773817235937235 4448 229346 A bile salt which induces apoptosis.
SGTC_2166 5933061 31.504 µM -1.42640807250923 0.105113460999435 no 2996 0.076875292447275 4501 2877375
SGTC_934 2950-0684 338 µM -1.42852645123465 0.104769130437927 no 2997 0.0765701933625222 4461 1121253
SGTC_337 1315-0038 354 µM -1.43295640899118 0.104051707337184 no 2998 0.0759351475574697 4432 1626437
SGTC_2756 carbadox 75.1 µM -1.43484173482664 0.103747465439229 no 2999 0.0756661010402977 4389 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_769 0302-0231 76 µM -1.43709521759861 0.103384660049044 no 3000 0.075345469967495 4369 571869 YER009W NTF2
SGTC_349 k015-0014 24 µM -1.43846298857486 0.103164901798867 no 3001 0.0751513658225781 4472 2196908
SGTC_2200 6600604 21.907 µM -1.44141452656988 0.102691837704375 no 3002 0.0747338043758009 4483 2904777
SGTC_2399 5884133 200 µM -1.44149016949271 0.102679734627554 no 3003 0.0747231262971521 4416 722445
SGTC_1281 0884-0031 11.8 µM -1.44256328672053 0.102508144575512 no 3004 0.0745717658642529 4466 1548255
SGTC_3007 9078383 71.4286 µM -1.44284487706542 0.102463153194323 no 3005 0.0745320870549885 4466 6496995
SGTC_2420 aureobasidin a 50 nM -1.44383541336764 0.102305003344658 no 3006 0.0743926389339989 4528 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_725 1497-0963 19 µM -1.44441543375145 0.102212479262536 no 3007 0.0743110759436082 4541 3549977
SGTC_1803 st050068 52.4 µM -1.44641393295657 0.101894147518811 no 3008 0.0740305681175264 4493 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1575 cyproterone acetate 48 µM -1.44929216095775 0.101436956666902 no 3009 0.0736280046656642 4448 9880 An androgen receptor antagonist and liver toxin.
SGTC_94 0334-0113 514.748 µM -1.45130110816737 0.101118732978364 no 3010 0.0733480164330933 4482 6795178
SGTC_1659 st012954 42.1 µM -1.45282156480056 0.10087837192807 no 3011 0.0731366514331782 4451 24207262
SGTC_27 0485-0001 32.618 µM -1.45474126587024 0.100575491770617 no 3012 0.0728704518883672 4460 2054479
SGTC_1385 3091-4834 14.1 µM -1.45708432271453 0.100206716451334 no 3013 0.0725465526773898 4455 4072814
SGTC_677 0929-0063 136 µM -1.45723546657557 0.100182961749737 no 3014 0.0725256967938212 4494 1539583
SGTC_2249 haloperidol 116.36 µM -1.4599056994914 0.0997639690985396 no 3015 0.0721579963075113 4424 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2251 lansoprazole 556 µM -1.46352131631807 0.0991986762340185 no 3016 0.0716623925922971 4438 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2830 7992007 71.43 µM -1.46469317513184 0.099015962533529 no 3017 0.0715023239055063 4365 1952075
SGTC_2098 5376439 882.5 nM -1.46474211427778 0.0990083374060204 no 3018 0.0714956450931266 4521 2844116
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.46505565496067 0.0989594953413557 no 3019 0.0714528669960072 4513 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2913 7966556 36.57 µM -1.46553227244497 0.0988852836164262 no 3020 0.0713878770535119 4373 2976516
SGTC_3174 9107204 49.47 µM -1.46567659847422 0.0988628193662043 no 3021 0.071368206198101 4478 3938802
SGTC_2495 cafestol 54.53 µM -1.46988058818426 0.0982101087362228 no 3022 0.0707970489275955 4470 16667697 An anti-infammatory.
SGTC_374 0880-0231 82.3 µM -1.4699110184913 0.0982053956678137 no 3023 0.0707929274831954 4345 6833587
SGTC_1837 st055472 66.5 µM -1.47221241816898 0.0978494331149791 no 3024 0.0704817625179425 4522 676091
SGTC_3203 9113543 49.47 µM -1.47360620473405 0.0976343134088507 no 3025 0.0702938248956487 4499 17018012
SGTC_9 0092-0002 10.449 µM -1.47430612203013 0.0975264177121055 no 3026 0.0701995937948156 4478 759368
SGTC_2685 mycophenolic acid 18.85 µM -1.47730605564335 0.0970649537573531 no 3027 0.0697968077394155 4480 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3104 9120930 49.47 µM -1.4800008007199 0.0966518035280483 no 3028 0.0694365164890924 4516 17014836
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.49096033924788 0.0949848266461162 no 3029 0.0679859539789592 4491 688798
SGTC_1500 4488-1866 171 µM -1.4928811713937 0.0946948571438528 no 3030 0.0677341472951002 4531 2900003
SGTC_870 0573-2213 57.6 µM -1.49514314801118 0.0943542255060155 no 3031 0.0674385435429549 4476 3916321
SGTC_1850 st056238 17 µM -1.49538282419241 0.0943181856219609 no 3032 0.0674072802538113 4500 5393177
SGTC_3268 9137683 49.47 µM -1.495706846678 0.0942694788045771 no 3033 0.0673650326681453 4556 1953228
SGTC_857 0438-0306 1.35 µM -1.49907156079543 0.0937647936610609 no 3034 0.0669275342370095 4535 4686136
SGTC_1170 0310-0127 64.8 µM -1.4996430050662 0.093679279265245 no 3035 0.0668534507753913 4494 774975
SGTC_765 1319-0117 244 µM -1.50322087523056 0.0931451735909108 no 3036 0.0663910480660862 4471 3487746 YGL099W LSG1
SGTC_380 3970-0968 6 µM -1.50508089149311 0.0928684003802929 no 3037 0.0661516405426612 4397 2891601
SGTC_553 k007-0256 45.7 µM -1.50560360299205 0.0927907296870236 no 3038 0.0660844815035166 4547 6287000
SGTC_3281 9140613 49.47 µM -1.50729045112302 0.0925404053700773 no 3039 0.0658681120563871 4478 16013766
SGTC_1525 8-methoxypsoralen 92.5 µM -1.51558847316638 0.0913162687919065 no 3040 0.0648117217699506 4527 4114 Related to psoralen; DNA damaging agent.
SGTC_1290 0986-0249 10.2 µM -1.51995670918704 0.0906767032531697 no 3041 0.0642609281222108 4367 53329
SGTC_2792 7535235 81.82 µM -1.52052535002348 0.0905936921415022 no 3042 0.0641894962537799 4476 1281891
SGTC_2634 4'-methoxyflavone 100 µM -1.52833535772376 0.089459276541591 no 3043 0.0632146477206145 4497 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.52888287961555 0.0893801462480061 no 3044 0.063146740592371 4412 4330530
SGTC_2905 7799065 20.05 µM -1.52911712183777 0.0893463084295878 no 3045 0.0631177057466161 4396 1296806
SGTC_587 k089-0003 57 µM -1.52923649900271 0.0893290672850413 no 3046 0.063102912680829 4427 9659696
SGTC_3022 9087993 49.47 µM -1.53137129822859 0.0890211649260784 no 3047 0.0628388267376857 4588 17173644
SGTC_682 0kpi-0099 17 µM -1.53360583105247 0.0886997248852381 no 3048 0.0625633264687335 4511 1714895 YML126C ERG13
SGTC_2394 5221648 200 µM -1.53436589377294 0.0885905862657694 no 3049 0.0624698316385008 4536 788586
SGTC_146 3448-8650 53.125 µM -1.5365023080976 0.0882843508989008 no 3050 0.0622076160717562 4488 2891488 YIL048W NEO1
SGTC_586 0957-0265 8.15 µM -1.53848921950941 0.0880002541112423 no 3051 0.0619645212118968 4421 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.54331911965794 0.0873124985526114 no 3052 0.0613766834198231 4573 368090
SGTC_1749 st037932 54.2 µM -1.54514417176652 0.0870536668042159 no 3053 0.0611556973229615 4516 594497
SGTC_1268 0828-0275 2.46 µM -1.54714517348048 0.0867705406943623 no 3054 0.0609141215422634 4561 745337
SGTC_245 methotrexate 289.6 µM -1.55209049693068 0.0860737685182091 no 3055 0.060320285755064 4471 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3038 9091290 49.47 µM -1.55547715350677 0.0855990255025287 no 3056 0.0599162358054987 4512 25236843
SGTC_471 1-acyl-paf 4 µM -1.55710836204821 0.0853710627802853 no 3057 0.0597223800205564 4497 16759367
SGTC_3251 9135047 49.47 µM -1.55758016240391 0.0853052131594705 no 3058 0.0596664021286523 4570 17682963
SGTC_1784 st039334 36.3 µM -1.56184734153266 0.0847113664378293 no 3059 0.0591619780591251 4530 3496984
SGTC_2161 5662504 8.5105 µM -1.56233286293359 0.08464399523981 no 3060 0.0591047970346079 4512 2859334
SGTC_431 k089-0097 107 µM -1.56634807484101 0.0840883820026394 no 3061 0.0586335759907197 4249 5499420
SGTC_701 4424-0219 185 µM -1.56844081855635 0.0837998818954576 no 3062 0.0583891456597699 4550 2911779
SGTC_2219 9098279 200 µM -1.56925463085539 0.0836878928817705 no 3063 0.0582943096047637 4464 902349
SGTC_1892 st058411 7.36 µM -1.57339891949432 0.0831193393839496 no 3064 0.0578132385247533 4534 3934738
SGTC_1362 1611-0397 101 µM -1.57872159071362 0.082393391204121 no 3065 0.0571999651369418 4520 27816
SGTC_1734 st037168 69.4 µM -1.58497571638435 0.0815465161390746 no 3066 0.0564859258632616 4539 708907
SGTC_2953 9074162 66.49 µM -1.58700164841269 0.08127359569962 no 3067 0.0562561356422509 4520 16451992
SGTC_845 0330-0138 4.51 µM -1.58784852924574 0.0811597138521608 no 3068 0.0561602973517048 4495 9039800
SGTC_2690 usnic acid 100 µM -1.58867431313472 0.0810487849429257 no 3069 0.0560669705395109 4542 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1156 4092-0367 4.88 µM -1.58934922386746 0.0809582080827909 no 3070 0.0559907856814487 4584 1357585
SGTC_367 0335-0881 7.1 µM -1.59535079722712 0.0801561207675293 no 3071 0.0553169060990871 4477 23828853
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.60038034578185 0.079488579256135 no 3072 0.0547571162632862 4537 1377
SGTC_2892 9047358 58.44 µM -1.60305498333669 0.0791353086464423 no 3073 0.0544612577478756 4547 6466771
SGTC_128 0906-2981 13.371 µM -1.60450535974153 0.0789442383134485 no 3074 0.054301351998294 4535 6740226
SGTC_2414 st077232 92.9 µM -1.60793932336672 0.0784932466749208 no 3075 0.0539242342053841 4490 729801
SGTC_789 1309-1135 70.6 µM -1.61144000981556 0.0780355053257581 no 3076 0.053541926336171 4538 3092424
SGTC_1305 1181-0477 144 µM -1.61579901006077 0.0774683672946198 no 3077 0.0530688878347334 4587 6252086
SGTC_768 0384-0033 77.3 µM -1.61618336116233 0.077418510947507 no 3078 0.0530273375579575 4514 3965305 YMR134W ERG29
SGTC_3337 9144342 33.5465 µM -1.62135174894915 0.0767504552899607 no 3079 0.0524711112998762 4564 17682949
SGTC_3273 9137859 49.47 µM -1.62769010512325 0.0759371668293672 no 3080 0.051795306129775 4626 2377234
SGTC_3063 1327-0034 4 µM -1.63083540409799 0.0755360306502875 no 3081 0.051462527392958 4446 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2689 tacrolimus 100 µM -1.63227252911877 0.0753532849954664 no 3082 0.0513110438002131 4542 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2730 imipramine 71.33 µM -1.63281332503278 0.0752846044068618 no 3083 0.0512541318550327 4515 3696 A tricyclic antidepressant.
SGTC_2115 tiliquinol 12.7705 µM -1.63310997859167 0.0752469499488325 no 3084 0.0512229341484761 4537 71208 A bioactive hydroxyquinoline.
SGTC_2784 7567673 72.73 µM -1.63333093371362 0.0752189132810608 no 3085 0.0511997071215628 4482 3471247
SGTC_2136 5328288 199.296 µM -1.63422328836205 0.0751057647525179 no 3086 0.0511059871472652 4535 262395
SGTC_1325 1431-0015 227 µM -1.63530166987091 0.0749692016961426 no 3087 0.0509929118482849 4560 1103340
SGTC_1013 4112-3890 241 µM -1.64156233916308 0.0741801078927184 no 3088 0.0503403689541745 4539 705171
SGTC_1889 st059080 5.18 µM -1.64250590162008 0.0740617335511922 no 3089 0.0502426020552242 4539 176925 Isolated from Daphnopsis sellowiana.
SGTC_1466 k213-0079 57.5 µM -1.64352764774745 0.0739337135004269 no 3090 0.0501369049176313 4547 3657981
SGTC_703 3875-0075 71.8 µM -1.64851334692997 0.073311452972093 no 3091 0.049623687060273 4603 2850814
SGTC_1986 st071812 45 µM -1.6519565838942 0.0728840500061113 no 3092 0.0492717008908385 4518 11838594
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.6536987642138 0.0726685242313002 no 3093 0.0490943669385908 4572 688669
SGTC_60 0986-0278 202 µM -1.65667330909869 0.0723016707050139 no 3094 0.0487927710432066 4518 3110598
SGTC_2726 cimetidine 79.27 µM -1.65738876523173 0.072213644890177 no 3095 0.048720450671012 4576 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1684 st024538 14.6195 µM -1.65994726589877 0.0718995328988469 no 3096 0.0484625308306292 4559 6732859
SGTC_1218 1348-1416 30.7 µM -1.66322282911402 0.0714989164437551 no 3097 0.048133919749803 4552 6787668
SGTC_2575 plumbagin 510 nM -1.67841127442794 0.0696636524522452 no 3098 0.0466334190691708 4516 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_302 1094-0063 18.9 µM -1.67917483041079 0.0695723562117241 no 3099 0.0465589878921168 4583 5440289
SGTC_3208 9114115 49.47 µM -1.68026243643981 0.0694424733215359 no 3100 0.0464531330788584 4533 650895
SGTC_1455 4262-0120 131 µM -1.68070714478121 0.0693894196716668 no 3101 0.0464099060671537 4608 1529587
SGTC_1876 myriocin 605 nM -1.68154357312571 0.0692897184603894 no 3102 0.0463286901591437 4558 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_483 fpl-64176 144 µM -1.68334523752472 0.0690753372224108 no 3103 0.0461541389241817 4685 3423
SGTC_1124 fisetin 1.16336 µM -1.68469047118645 0.0689156005736711 no 3104 0.0460241529515923 4584 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_562 3772-2733 112 µM -1.68667895842218 0.0686800040097376 no 3105 0.045832550102216 4559 2876874 YIL048W NEO1
SGTC_1457 k015-0032 57.3 µM -1.6899981163767 0.068288133480901 no 3106 0.0455141575032065 4586 4302660
SGTC_3060 1327-0027 12.5 µM -1.69257860474013 0.067984666652445 no 3107 0.0452678532011125 4514 16000455 YPR107C YTH1
SGTC_2337 9009472 200 µM -1.69412113287664 0.067803762392886 no 3108 0.0451211336778351 4540 5742383
SGTC_2877 9040724 71.43 µM -1.69746295146983 0.0674131168477622 no 3109 0.0448045848698856 4549 6463895
SGTC_2621 lithochol-11-enic acid 100 µM -1.6990492836575 0.0672282907304675 no 3110 0.0446549490351038 4536 6708711
SGTC_213 1246-0773 967 nM -1.70247635193033 0.0668303351789375 no 3111 0.044333053922415 4614 6251622
SGTC_2568 diosmetin 100 µM -1.70306033950287 0.0667627039164313 no 3112 0.0442783885110041 4597 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1422 4031-0024 15.5 µM -1.71157021907721 0.0657831778448874 no 3113 0.0434879502251535 4541 782427
SGTC_3311 9131146 2.8755 µM -1.71455163962794 0.0654426501316643 no 3114 0.0432137308376697 4554 4900406 YPR165W RHO1
SGTC_2374 9071832 200 µM -1.71488974895287 0.0654041189062059 no 3115 0.043182721225201 4541 17381698
SGTC_3211 9128781 49.47 µM -1.71952874609772 0.0648772301295378 no 3116 0.0427590689963754 4507 17194361
SGTC_514 4466-0038 2.65 nM -1.72214502044537 0.0645815351691821 no 3117 0.0425216257061942 4400 5722064
SGTC_3316 9136639 10.545 µM -1.72583063991014 0.0641667587761428 no 3118 0.0421889429144602 4586 4903665
SGTC_1358 1509-0022 2.48 µM -1.72606440095047 0.0641405215092121 no 3119 0.042167913682917 4622 3258434
SGTC_1044 1222-0021 1.78 µM -1.72918999007934 0.0637905070792372 no 3120 0.0418875486405008 4526 4306703
SGTC_1392 3455-1037 33.9 µM -1.73850655152912 0.0627560168545354 no 3121 0.0410607983478573 4611 981132
SGTC_524 r073-0010 27.8 µM -1.74635450564478 0.0618947825955866 no 3122 0.0403746850488608 4556 2772106
SGTC_473 2-arachidonoylglycerol 10 µM -1.76111760305298 0.0602997079962314 no 3123 0.0391092501080162 4479 5282280 An endocannabinoid.
SGTC_287 k060-0039 29.6 µM -1.76302562429238 0.0600959256684446 no 3124 0.0389480839961313 4648 5861974
SGTC_3266 9136860 49.47 µM -1.76654529706156 0.0597214293719584 no 3125 0.038652204578611 4358 4871271 YPR165W RHO1
SGTC_29 0299-0004 12.984 µM -1.77035195273464 0.0593184586459741 no 3126 0.038334264228036 4547 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2054 5233173 129 µM -1.77517605340327 0.0588108480854426 no 3127 0.0379344112016017 4600 6889
SGTC_1810 st050138 53 µM -1.77587581800806 0.0587375000949176 no 3128 0.0378766937641828 4625 3444541
SGTC_3220 9131269 49.47 µM -1.77929906322142 0.0583797163245155 no 3129 0.0375953722370718 4616 17722206
SGTC_2850 9015429 58.44 µM -1.78649472592163 0.0576332363850077 no 3130 0.0370095952086784 4602 6457570
SGTC_608 k048-0125 159 µM -1.7894358041309 0.0573302977453834 no 3131 0.0367723287293028 4655 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2021 4019055 173 µM -1.79314685397994 0.0569498395860137 no 3132 0.0364747227140803 4406 44827708 YER133W GLC7
SGTC_2502 avocadyne acetate 18.59 µM -1.79629613828265 0.0566285356906099 no 3133 0.0362237158562453 4595 3952079
SGTC_568 1193-0097 7.48 µM -1.79889316847502 0.0563646511385234 no 3134 0.0360177907249552 4434 3646150
SGTC_984 1492-0255 2.91 µM -1.80860787408762 0.0553861240735859 no 3135 0.0352559721659881 4588 1585198
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.81461301430993 0.0547879886719042 no 3136 0.0347917005408494 4596 364106
SGTC_403 arphamenine a 50 µM -1.81812623352886 0.0544404328653751 no 3137 0.0345224206308012 4642 5487158 An arginine aminopeptidase inhibitor.
SGTC_1694 st024011 44.9 µM -1.83169872073064 0.053114089644092 no 3138 0.0334981596870012 4672 2787533
SGTC_2470 5664817 21.68 µM -1.8383314638735 0.0524753051022346 no 3139 0.0330067887297479 4692 2859561
SGTC_49 0717-0965 32.132 µM -1.84100401866204 0.0522196473928982 no 3140 0.0328104848980263 4678 5889349 YGL099W LSG1
SGTC_1504 k297-0033 30 µM -1.84664588217871 0.0516831930092448 no 3141 0.032399239905319 4564 4388117
SGTC_2539 epi(13)torulosol 80 µM -1.84955725660549 0.0514080848355981 no 3142 0.032188694112037 4604 6708597
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.85684327147496 0.0507247017852117 no 3143 0.0316667276898866 4611 115019
SGTC_2939 9044578 71.43 µM -1.86509553127005 0.0499594492912942 no 3144 0.0310840074221257 4588 2653634
SGTC_1842 st055362 61.2 µM -1.86563423638283 0.0499098157075581 no 3145 0.031046278131123 4632 676032
SGTC_384 k007-0144 5.16 µM -1.86796420494241 0.0496955968361082 no 3146 0.0308835302248247 4623 6824886
SGTC_3142 9086498 49.47 µM -1.87020666406458 0.0494901170539723 no 3147 0.0307275623315721 4527 25236367
SGTC_655 k060-0012 42 µM -1.87311252270972 0.0492248583830967 no 3148 0.0305264242326916 4660 5994525
SGTC_1428 4049-0204 61.7 µM -1.88037127685743 0.0485672084702575 no 3149 0.0300287476604017 4688 X1428
SGTC_2549 cedrol 20.94 µM -1.88210615837719 0.0484110713405188 no 3150 0.029910801691303 4622 6708665 A sedative which affects the nervous system.
SGTC_2766 oltipraz 83.91 µM -1.88538107579029 0.0481174272829699 no 3151 0.0296892035585606 4628 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_693 4161-2696 114 µM -1.8878408738213 0.0478978092362368 no 3152 0.0295236580470177 4672 805759
SGTC_1282 0886-0010 32.4 µM -1.8935586002598 0.0473904137958561 no 3153 0.029141811523946 4666 2836211 YNL267W PIK1
SGTC_340 k038-0059 454 µM -1.89460159140256 0.0472983241122661 no 3154 0.0290726019058878 4646 23733424
SGTC_1562 morin hydrate 59.1 µM -1.89464560391667 0.0472944412346473 no 3155 0.0290696843793427 4656 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3153 9100258 49.47 µM -1.89981078535874 0.0468405292604755 no 3156 0.0287289775207785 4577 25236848
SGTC_263 alizarin 107.927 µM -1.89981684893621 0.0468399984589949 no 3157 0.0287285795134403 4675 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1855 st056195 39.6 µM -1.90892012875007 0.0460485285155991 no 3158 0.0281361979783604 4609 4028379
SGTC_993 3909-8757 62.7 µM -1.92028505857874 0.0450755405977041 no 3159 0.0274109513102616 4643 4288324 YLR208W SEC13
SGTC_2398 5228213 48.84 µM -1.92216091403561 0.0449165450459721 no 3160 0.027292756634715 4620 80771 YMR134W ERG29
SGTC_2371 9071574 200 µM -1.92466104652846 0.0447053386121104 no 3161 0.0271358883853658 4680 45596039
SGTC_3110 9122132 49.47 µM -1.9399229529319 0.0434333276871642 no 3162 0.0261945270684719 4677 918317
SGTC_106 0092-0003 11.579 µM -1.9399759814306 0.0434289594810134 no 3163 0.0261913044668841 4629 1072148
SGTC_2271 7849410 118.62 µM -1.94450563062545 0.0430571381105249 no 3164 0.0259172535444031 4615 972430
SGTC_678 1218-2179 85.9 µM -1.94503025895688 0.0430142400803417 no 3165 0.0258856682896198 4699 6820081 YOR116C RPO31
SGTC_1672 st016598 6.51 µM -1.94843966527616 0.0427362990168684 no 3166 0.0256811887812642 4634 4665860 YNL267W PIK1
SGTC_3287 9117173 37.0625 µM -1.9489764122 0.0426926749824314 no 3167 0.0256491208438695 4692 2789709
SGTC_369 0957-0393 4.5 µM -1.95616716341715 0.0421117121394877 no 3168 0.0252227326608653 4656 6997992
SGTC_2519 cryptotanshinone 88.04 µM -1.95825920018963 0.0419438968344591 no 3169 0.0250998028356099 4675 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_994 3910-0338 138 µM -1.96164363302567 0.041673557161768 no 3170 0.0249019942815322 4686 3479481
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.96439260626351 0.0414550165921211 no 3171 0.0247422898108455 4619 676296 Flavone; oxidizing agent.
SGTC_2517 totarol 10 µM -1.96709035179287 0.0412414523868248 no 3172 0.0245863976848211 4677 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1963 st076565 50.3 µM -1.972456380142 0.0408193079807468 no 3173 0.0242787655568113 4699 4914280
SGTC_2128 5255449 168.493 µM -1.97559812016217 0.0405737795190754 no 3174 0.0241001558640124 4601 736008
SGTC_1299 1079-1439 3.74 µM -1.97698893184252 0.0404654704143001 no 3175 0.0240214406503431 4674 323161
SGTC_2651 TUB2.036 5 µM -1.98195979667598 0.0400802829123972 no 3176 0.0237418702314786 4555 15992207 YFL037W TUB2
SGTC_1416 3966-0321 25.3 µM -1.98499940288407 0.0398462181943258 no 3177 0.0235722689661178 4723 582530 YLR208W SEC13
SGTC_3009 9080819 71.4286 µM -1.99622514793664 0.0389913923791473 no 3178 0.0229547106572322 4697 17027216
SGTC_458 nppb 133 µM -2.001958724691 0.0385605833079245 no 3179 0.0226445854480505 4700 4549 A chloride channel blocker.
SGTC_1522 st012842 45.6 µM -2.00405172453925 0.0384042893248415 no 3180 0.022532259971046 4536 3491067 YOR116C RPO31
SGTC_2720 fluspirilene 36.88 µM -2.00758962636256 0.0381412723027837 no 3181 0.0223434589092447 4685 3396 An atypical antipsychotic.
SGTC_1469 k284-2957 126 µM -2.01006777750846 0.0379579163443926 no 3182 0.0222120079403341 4696 23884841
SGTC_513 4245-1575 41.7 µM -2.01165528154829 0.0378408368498902 no 3183 0.0221281438080542 4524 719745
SGTC_408 cantharidin 100 µM -2.02699997023248 0.0367242802451907 no 3184 0.0213312078597932 4685 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1880 MG-132 525 µM -2.02928420433238 0.0365603956504408 no 3185 0.0212146756117834 4661 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1377 2944-0135 198 µM -2.03020994054476 0.036494148415995 no 3186 0.0211676019185271 4679 1894137
SGTC_3175 9106517 49.47 µM -2.03156315858221 0.0363974866279819 no 3187 0.0210989497731348 4697 41468073
SGTC_1555 citronellol 128 µM -2.04756467895885 0.0352702912630471 no 3188 0.0203013366210363 4694 8842 A terpine precursor.
SGTC_809 3998-0021 90 µM -2.05276135952787 0.0349104406801128 no 3189 0.0200478638977051 4672 715485
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.0557240809449 0.0347066358571777 no 3190 0.0199045597053503 4698 616764
SGTC_2456 5770359 74.46 µM -2.06673166126061 0.033957969051046 no 3191 0.0193797230226517 4671 3118787
SGTC_295 k015-0027 31 µM -2.06958572073563 0.0337660372845164 no 3192 0.0192455781935433 4733 3887424
SGTC_293 4049-0273 38.5 µM -2.07065890684617 0.0336940982203386 no 3193 0.0191953415051722 4613 1380311
SGTC_2627 acetyl isogambogic acid 100 µM -2.07178495437488 0.0336187513312399 no 3194 0.0191427502152227 4684 6857789 A caspase activator and apoptosis inducer.
SGTC_3288 9119690 36.221 µM -2.08734147321 0.0325919411156113 no 3195 0.0184286391833396 4693 17595618 YKL019W RAM2
SGTC_2675 theaflavin digallate 100 µM -2.09215439332021 0.032279553024226 no 3196 0.0182123533631264 4659 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.10480302779814 0.0314703433135941 no 3197 0.0176542287557766 4683 5379071
SGTC_3141 9094609 49.47 µM -2.11183802285862 0.0310275774641226 no 3198 0.0173501723834523 4666 25236309 YDL196W YDL196W
SGTC_256 clotrimazole 625 nM -2.11652852808829 0.0307352419446898 no 3199 0.0171499407693721 4661 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2836 9010338 19.48 µM -2.11670299192407 0.0307244126337661 no 3200 0.0171425313816389 4653 2994051
SGTC_336 4111-0029 111 µM -2.11833744489658 0.0306231123056489 no 3201 0.0170732497807948 4720 3131175
SGTC_445 e6 berbamine 66 µM -2.12333208019112 0.030315266949999 no 3202 0.0168630171397665 4703 6610268 A calcium/calmodulin antagonist.
SGTC_589 1227-0070 34.1 µM -2.12435658422865 0.0302524394613728 no 3203 0.0168201687461741 4729 2841384
SGTC_1753 st043925 64 µM -2.12855856214137 0.0299958820457713 no 3204 0.0166453999776462 4713 670181
SGTC_1718 roemerine 11.9335 µM -2.14199328283332 0.029187685867172 no 3205 0.0160970112823502 4352 235224 An aporphine alkaloid with mutagenic activity.
SGTC_491 tetrandrine 80.3 µM -2.1453414909491 0.0289891071385442 no 3206 0.015962776710698 4725 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1437 4092-1038 11.6 µM -2.14909739931245 0.0287676856112593 no 3207 0.0158133399408995 4749 3977136
SGTC_869 0564-0080 44.1 µM -2.15082736397988 0.028666173251045 no 3208 0.0157449142014842 4708 6843321
SGTC_1019 4262-0212 3.4 µM -2.15168218300303 0.0286161235115456 no 3209 0.0157111971797869 4685 4677213
SGTC_2947 9072639 7.68 µM -2.15866723314004 0.0282098654455476 no 3210 0.0154379963090808 4657 16488146
SGTC_1010 4112-3296 15.2 µM -2.16664784659748 0.0277515923295399 no 3211 0.0151308580598897 4722 704384
SGTC_2188 6126565 140.678 µM -2.16991738394897 0.0275656444381053 no 3212 0.0150065525733834 4681 874518
SGTC_1381 2324-0066 62.1 µM -2.17216481359247 0.0274384299876833 no 3213 0.014921616832282 4721 10885928
SGTC_3326 9140064 16.379 µM -2.17317179760374 0.027381589257447 no 3214 0.0148836947777765 4682 1868434
SGTC_2450 5739737 12.93 µM -2.17322445828937 0.0273786194495796 no 3215 0.0148817139088713 4714 2262825
SGTC_1568 digitonin 820 nM -2.17451904925295 0.0273056952135837 no 3216 0.0148330881896968 4687 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_610 4215-0184 155 µM -2.17571648634708 0.0272383879480045 no 3217 0.0147882333345915 4724 5605015
SGTC_3296 9122258 64.045 µM -2.18066814050209 0.0269615260478025 no 3218 0.0146039855720116 4688 4730474
SGTC_889 0919-1524 82.7 µM -2.18398090792784 0.026777613815986 no 3219 0.0144818255034537 4736 3905452
SGTC_3249 9135183 49.47 µM -2.19652940630306 0.0260904424219013 no 3220 0.0140270363832149 4695 4902779
SGTC_2409 alverine citrate 63.97 µM -2.2008079307432 0.0258595427454039 no 3221 0.0138748119590908 4682 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2981 9013952 38.96 µM -2.20151727333427 0.025821427295319 no 3222 0.0138497126138409 4666 2996344
SGTC_1209 2323-2347 50.3 µM -2.20220685166116 0.0257844189256862 no 3223 0.0138253501504479 4719 5412760
SGTC_2068 5226020 147 µM -2.2272549404077 0.0244699212169023 no 3224 0.012965120076426 4728 1810509
SGTC_2780 5215298 71.43 µM -2.24014890887307 0.0238154887147376 no 3225 0.0125406286204397 4725 2834131
SGTC_2569 tetrandrine 100 µM -2.24339703062652 0.0236529704258989 no 3226 0.0124356116039637 4720 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_255 tunicamycin 200.472 nM -2.24770555455622 0.0234388353764091 no 3227 0.0122974857936938 4692 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_805 3852-0218 479 µM -2.26641300118402 0.0225278925415834 no 3228 0.0117130541560454 4734 6615355
SGTC_1545 lovastatin 49.4 µM -2.27129275166304 0.0222952470347221 no 3229 0.0115646308658039 4757 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_674 0498-0004 451 µM -2.27240222862057 0.0222426356934492 no 3230 0.0115311136187152 4719 4231473
SGTC_2301 7769476 200 µM -2.27304484230493 0.0222122109197735 no 3231 0.0115117388982817 4715 977820
SGTC_1000 4048-0884 8.67 µM -2.27887590449848 0.0219377388175772 no 3232 0.0113372215706964 4731 13040088
SGTC_1425 4048-4433 7.33 µM -2.27959089835382 0.0219042815043143 no 3233 0.0113159816374021 4770 23734946
SGTC_1355 1499-0035 1.68 µM -2.28216540075255 0.0217841673111692 no 3234 0.0112397884837153 4754 1548538
SGTC_806 3966-4455 5.86 µM -2.28701057326866 0.0215596228158105 no 3235 0.0110976029771213 4736 714982
SGTC_393 acivicin 6.25 µM -2.30133949599924 0.0209069789185978 no 3236 0.010686224468933 4645 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3343 9148379 18.9835 µM -2.3054203873706 0.0207241936945009 no 3237 0.0105715203890588 4751 1955036
SGTC_1412 3909-8563 178 µM -2.31030028373083 0.0205073990160143 no 3238 0.0104357676200954 4774 23767530
SGTC_3340 9146634 11.102 µM -2.31485705957195 0.02030669724529 no 3239 0.0103103780097893 4729 4907387
SGTC_817 1391-0715 46 µM -2.31683990890144 0.0202198845765746 no 3240 0.0102562270756024 4742 1353946
SGTC_3181 9108277 49.47 µM -2.31821695491357 0.0201597803775166 no 3241 0.0102187665132593 4738 17097298
SGTC_2718 lomofungin 53.02 µM -2.32016001716147 0.0200752289204124 no 3242 0.0101661113119188 4716 5351222 A RNA synthesis inhibitor.
SGTC_2566 crystal violet carbinol 226 nM -2.32611924011914 0.0198177895543771 no 3243 0.0100060952045617 4667 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1446 4239-0190 62 µM -2.33059488419847 0.0196262883130716 no 3244 0.00988736575148937 4749 1340085
SGTC_551 k048-0028 34.9 µM -2.33273170298424 0.0195354149592324 no 3245 0.00983111559029106 4710 6836383
SGTC_833 3852-0053 558 µM -2.33784348582358 0.019319473089433 no 3246 0.00969768442141115 4751 3123681
SGTC_981 1488-1094 54.9 µM -2.3462716965221 0.018967861967486 no 3247 0.00948113958203789 4720 3449522
SGTC_1101 ebselen 5.29 µM -2.34650699007362 0.018958124519695 no 3248 0.00947515537468063 4755 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_457 grayanotoxin iii 135 µM -2.36857696862719 0.0180634841309171 no 3249 0.0089283322453801 4584 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1648 st011736 69.8 µM -2.37056002137493 0.0179848898882253 no 3250 0.00888057993145847 4751 2855514
SGTC_1548 st061468 90.8 µM -2.38224098894459 0.0175278319952347 no 3251 0.00860381616889869 4771 390799
SGTC_1800 st050079 29.0735 µM -2.38731690920568 0.0173323314215578 no 3252 0.00848592707498889 4632 3645560
SGTC_1024 4507-0395 26 µM -2.41916481798007 0.0161477186294545 no 3253 0.00777809495377517 4755 4201836
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.42422230610859 0.015966133138453 no 3254 0.00767060557734461 4750 4000243
SGTC_2070 5230947 200 µM -2.42895323183214 0.0157978600429074 no 3255 0.00757124274727256 4780 2835538
SGTC_2141 5621638 7.665 µM -2.43557688621945 0.015564821928947 no 3256 0.00743403223760869 4752 2856238
SGTC_1505 k297-0037 20.6 µM -2.45288039480617 0.0149699120877177 no 3257 0.0070858725433604 4752 4089396
SGTC_888 0916-0002 6.97 µM -2.4543029713819 0.0149218839739784 no 3258 0.00705789979361877 4754 2802138 YIL048W NEO1
SGTC_217 ketoconazole 989 nM -2.455018903569 0.0148977632849305 no 3259 0.007043859000782 4630 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1559 coumarin 343 70.1 µM -2.47402473760203 0.014269578424229 no 3260 0.00668002228145011 4763 108770 A hepatotoxic, DNA x-linker.
SGTC_3348 9149464 3.537 µM -2.47955429495552 0.014091154105457 no 3261 0.00657733503764727 4744 1951442
SGTC_1658 st012944 20 µM -2.48259078908938 0.0139939946459148 no 3262 0.0065215412878906 4653 24207260
SGTC_3329 9141233 27.5565 µM -2.48509650195897 0.0139142541481762 no 3263 0.00647581598844099 4734 4909101 YNL103W MET4
SGTC_1567 st069303 68.4 µM -2.50398416675126 0.0133256923673467 no 3264 0.00614017648146662 4744 5581319
SGTC_231 b-estradiol 524 µM -2.52057589233477 0.0128265401380102 no 3265 0.00585814849532857 4776 450 A steroid.
SGTC_779 1360-0071 233 µM -2.5227721020087 0.0127616960425462 no 3266 0.00582169158778864 4762 7566
SGTC_268 camptothecin 39.6153 µM -2.53675711934838 0.0123553980389387 no 3267 0.00559422739719502 4727 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1396 3511-0007 98.6 µM -2.55633340866045 0.0118055050125711 no 3268 0.00528908545911463 4765 X1396
SGTC_976 1348-1067 47.6 µM -2.55944862925144 0.0117199870622073 no 3269 0.00524191745800514 4776 5310671 YGL099W LSG1
SGTC_2490 carminic acid 95.39 µM -2.56227578733494 0.0116428428229926 no 3270 0.0051994353513171 4744 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2923 7992654 58.14 µM -2.57485203039277 0.0113049952602815 no 3271 0.00501414891743838 4740 2985126
SGTC_1560 lithocholic acid 53.1 µM -2.593784879445 0.0108124579026258 no 3272 0.00474629303670559 4755 9903 A bile acid which acts as a detergent.
SGTC_1826 st055655 41.6 µM -2.6019298400867 0.010606380908693 no 3273 0.00463504073441595 4761 676168
SGTC_1112 tnp00069 1.16933 µM -2.61203299915891 0.0103555197518786 no 3274 0.0045002782989376 4760 145826
SGTC_2952 9073731 13.78 µM -2.63876449786941 0.00971657098605491 no 3275 0.00416043810659122 4745 16457353
SGTC_955 1216-0110 33 µM -2.64512290748341 0.00956975951086519 no 3276 0.00408306247911673 4744 3619719
SGTC_866 0495-0101 262 µM -2.64603006975673 0.00954897258819191 no 3277 0.00407212882528482 4770 635694
SGTC_1431 4049-0260 9.09 µM -2.66036855161225 0.00922562131699294 no 3278 0.00390275942138053 4796 3854841
SGTC_1674 st016616 23.6 µM -2.67631483194679 0.0088773048350696 no 3279 0.00372183425704596 4764 625830
SGTC_1324 1418-0026 34.4 µM -2.71946911435062 0.00799184027682965 no 3280 0.00326934005499036 4784 1372513
SGTC_2776 terbinafine 19.92 µM -2.72095122469368 0.0079628602777656 no 3281 0.00325471826870306 4770 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1840 st055363 71 µM -2.72713372603166 0.00784296692783061 no 3282 0.00319435708743058 4778 676033
SGTC_1314 1222-0010 41.1 µM -2.73060125422878 0.00777642084077545 no 3283 0.00316094548923163 4774 3526027
SGTC_1950 st077106 7.18 µM -2.74333357829782 0.00753631441301119 no 3284 0.00304094339040213 4747 13831864
SGTC_1656 st012921 11 µM -2.75368334616254 0.00734597420138461 no 3285 0.00294643763784348 4743 6732821
SGTC_1279 0874-0590 65.2 µM -2.76410610480927 0.00715858663614029 no 3286 0.00285394876300246 4799 3523074
SGTC_2779 methotrexate 400 µM -2.7665744295512 0.00711483176972319 no 3287 0.00283243259365906 4764 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_346 4513-0042 7.16 µM -2.79341863450926 0.00665400023788405 no 3288 0.00260770738499784 4754 2827372
SGTC_2482 5981709 142.65 µM -2.80423286415301 0.00647593998435424 no 3289 0.00252182316738653 4760 877755
SGTC_1103 duloxetine 36.1 µM -2.81621590477186 0.00628356971092351 no 3290 0.00242964992872698 4791 60835 A selective serotonin reuptake inhibitor.
SGTC_459 nigericin 15.3 µM -2.87440737992661 0.00541953587454767 no 3291 0.00202393237616483 4788 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2887 9044784 58.44 µM -2.87667278551711 0.00538814595342707 no 3292 0.0020094605067033 4748 6465546
SGTC_1558 st069300 45.6 µM -2.8778389148781 0.00537205092647643 no 3293 0.00200204771904727 4788 24208000
SGTC_743 1275-0778 158 µM -2.90205302850431 0.00504736538701969 no 3294 0.00185362889785998 4788 2849257 YMR203W TOM40
SGTC_2931 9014674 55.67 µM -2.94010724114784 0.00457233090613151 no 3295 0.00164049333769308 4761 2996810
SGTC_1994 st072947 40.9 µM -2.95012077524273 0.00445415561773175 no 3296 0.00158824865429305 4795 5286565 YDL195W SEC31
SGTC_2781 5567276 71.43 µM -2.95276963898701 0.00442335469324929 no 3297 0.00157468443532953 4764 2853274
SGTC_3294 9122953 26.2835 µM -2.97099765495832 0.00421651018648196 no 3298 0.00148417023668041 4778 16459826
SGTC_2778 tioconazole 65.09 nM -2.97827122218114 0.00413641702712362 no 3299 0.00144939672726156 4724 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2300 7976697 71.57 µM -3.01699127420852 0.00373252743073168 no 3300 0.00127648580316224 4746 2236109
SGTC_950 1165-0508 94.1 µM -3.01921429059809 0.00371045082529797 no 3301 0.00126715602516017 4765 6148369
SGTC_1304 1165-0502 251 µM -3.03430907532886 0.00356361797737947 no 3302 0.0012054364968484 4802 767425
SGTC_2440 5628896 157.78 µM -3.03686642256956 0.00353926500499053 no 3303 0.00119525682291331 4789 5522048
SGTC_1731 st035964 63 µM -3.05094852907869 0.00340782213755481 no 3304 0.00114059838359177 4754 6739575
SGTC_2273 7815444 169.05 µM -3.10934188696079 0.00290834664276635 no 3305 0.000937523060158591 4773 2824616
SGTC_1310 1188-0297 994 nM -3.1375450490173 0.00269160495388888 no 3306 0.000851845456179714 4778 1588352
SGTC_612 0302-0167 22.4 µM -3.13886150516203 0.00268185382863921 no 3307 0.000848027936672917 4788 235821
SGTC_2511 berberine 10.47 µM -3.13933117583333 0.0026783826579946 no 3308 0.00084666977730046 4783 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2437 5741531 144.16 µM -3.1478412909564 0.00261618616086277 no 3309 0.000822404854163353 4791 2262990
SGTC_339 3091-4833 71.4 µM -3.15565691767447 0.00256021798442104 no 3310 0.000800685507176674 4710 3240077
SGTC_2317 5986382 200 µM -3.16005593420845 0.00252919448867658 no 3311 0.000788694267245233 4791 877883
SGTC_1733 st037357 54.9 µM -3.16420484639767 0.00250024665551811 no 3312 0.000777536508870336 4773 1272339 YGL099W LSG1
SGTC_444 curcumin 90.4 µM -3.16964703101732 0.00246272968086258 no 3313 0.000763121088355819 4747 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3059 1327-0034 3 µM -3.17627215041876 0.00241774548761667 no 3314 0.000745904636301629 4752 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2389 9091542 195.52 µM -3.2139682305337 0.0021756475471998 no 3315 0.000654570785977331 4786 3626624 YOL127W RPL25
SGTC_1844 rapamycin 4 nM -3.22090734514163 0.00213355520450495 no 3316 0.000638927266545688 4712 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1818 st052136 56.3 µM -3.24381779766391 0.00199977330180424 no 3317 0.000589695813027825 4687 674169
SGTC_990 3985-0011 41.3 µM -3.2564841868684 0.00192912363454506 no 3318 0.000564006067517147 4791 5399565 YGL099W LSG1
SGTC_2858 9025781 8.96 µM -3.26930347346 0.00185993715556055 no 3319 0.000539063010075797 4719 4894980 YPL153C RAD53
SGTC_3349 9149703 23.001 µM -3.29244518816564 0.0017407254326454 no 3320 0.00049660127830453 4796 4910494
SGTC_2443 5493264 126.67 µM -3.37375900662766 0.00137492554446357 no 3321 0.000370746263729904 4804 5340055
SGTC_453 enantio-paf c16 10 µM -3.39813595204519 0.00127982326856946 no 3322 0.000339233474015903 4475 13871343 A lipid and platelet activating factor
SGTC_913 3487-1245 167 µM -3.40418517500979 0.00125717423260706 no 3323 0.000331808745671277 4784 4016153
SGTC_3286 9117135 37.221 µM -3.42904491308187 0.00116789421559946 no 3324 0.0003028546423723 4778 3438150
SGTC_2385 9074692 200 µM -3.44424977687329 0.00111618949416432 no 3325 0.000286323206799867 4799 17046906
SGTC_1859 st055998 20 µM -3.44506071588742 0.00111349169709923 no 3326 0.000285465566300545 4789 676301
SGTC_1368 1852-0141 284 µM -3.45173346720169 0.00109151890885469 no 3327 0.000278498822325723 4758 2838987
SGTC_2328 6201408 200 µM -3.53063853239092 0.000860170817294316 yes 3328 0.000207278930573684 4785 2890418
SGTC_1049 3226-0134 66 µM -3.55399077087388 0.000800907596722633 yes 3329 0.000189716264239629 4799 5702385
SGTC_1556 plumbagin 1.48 µM -3.57134669638628 0.000759322357064893 yes 3330 0.00017757520275818 4792 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1754 st042065 16.137 µM -3.59403153670339 0.000707966516549132 yes 3331 0.000162800200377491 4747 1126236 YIL048W NEO1
SGTC_736 0958-0254 92.6 µM -3.64934031254822 0.000595881302228845 yes 3332 0.000131457307479845 4804 6812352
SGTC_3147 9097027 49.47 µM -3.67601403738232 0.000547904575204082 yes 3333 0.000118453246314848 4801 25236841
SGTC_1553 gossypol 38.6 µM -3.68489543255148 0.00053274010371351 yes 3334 0.000114398277046775 4806 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3345 9148410 3.559 µM -3.74722716423772 0.000436760613738536 yes 3335 8.94000745953435e-05 4799 4903596
SGTC_2322 7413319 38.22 µM -3.75818555162772 0.000421643423260397 yes 3336 8.55749737341607e-05 4785 1840400
SGTC_1082 camptothecin 424.86 nM -3.80534019459858 0.000361967395233938 yes 3337 7.08047100981714e-05 4770 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2597 laccaic acid a 100 µM -3.86719797290095 0.000295547469824312 yes 3338 5.50465253126897e-05 4797 5491415 A textile dye.
SGTC_2485 5633444 17.78 µM -3.91984542844605 0.000248146702253829 yes 3339 4.43028896430709e-05 4803 5724239
SGTC_1787 fluconazole 80 µM -3.94947929424157 0.000224686391740556 yes 3340 3.9160692628327e-05 4662 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2504 purpurogallin 52.29 µM -4.02028626014302 0.000176747280198823 yes 3341 2.90637332942751e-05 4801 5281571 An antioxidant.
SGTC_2449 5812982 45.77 µM -4.1161477109418 0.000126948685012922 yes 3342 1.92628727568472e-05 4795 776185
SGTC_977 1348-1378 135 µM -4.17571882133064 0.000102989237283671 yes 3343 1.4852327626845e-05 4805 X977
SGTC_2452 5863136 48.41 µM -4.5785048496389 2.33287523132719e-05 yes 3344 2.34155654575086e-06 4801 2184096
SGTC_1707 st032323 6.317 µM -4.66551061432015 1.6654631265696e-05 yes 3345 1.53925801496689e-06 4801 3132057 YMR211W DML1
SGTC_2379 9035213 200 µM -4.72920864268024 1.29655894862364e-05 yes 3346 1.12698330307347e-06 4809 646551
SGTC_1055 3448-0672 86 µM -4.77680278564396 1.07315235398507e-05 yes 3347 8.90521462334684e-07 4807 748378
SGTC_2777 climbazole 1.536 µM -4.86877321215495 7.40999265795516e-06 yes 3348 5.61465948735294e-07 4772 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1054 3429-0080 167 µM -4.94886939904281 5.33883016994976e-06 yes 3349 3.73229055470348e-07 4810 1162877
SGTC_1047 2043-3044 82 µM -5.30964342924114 1.14716024572788e-06 yes 3350 5.49199575006826e-08 4808 669592
SGTC_670 4204-0025 119 µM -5.31571073321875 1.11691697247631e-06 yes 3351 5.31209065992226e-08 4808 719039
SGTC_2365 9042475 200 µM -6.04828254363868 3.59919660547307e-08 yes 3352 7.31990246257913e-10 4810 6464479
SGTC_2586 curcumin 80 µM -6.23148849919312 1.42848622395709e-08 yes 3353 2.31011959547205e-10 4809 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2582 agaric acid 100 µM -6.81535757018126 6.31162991559017e-10 yes 3354 4.70147962938341e-12 4793 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_151 3013-0144 2.285 µM -7.35033513605197 2.86657446210236e-11 yes 3355 9.88552515960839e-14 4803 906558 YHR107C CDC12
SGTC_2896 9052656 71.43 µM -7.83713443403574 1.41553331880523e-12 yes 3356 2.30472241277726e-15 4780 6469436