SGTCid condition conc unit NDJ1|YOL104C.score NDJ1|YOL104C.strain.pval NDJ1|YOL104C.strain.significant NDJ1|YOL104C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2540 epiandrosterone 100 µM 5.16310323673547 5.62601569462306e-08 yes 1 1.21444546380825e-07 30 441302 A steroid.
SGTC_1035 k081-0041 55.2 µM 5.01780799882957 1.24310617605064e-07 yes 2 2.613218523094e-07 11 731709
SGTC_464 bw-b 70c 158 µM 5.00965148832267 1.29887952607349e-07 yes 3 2.72643452316398e-07 5 5353454
SGTC_2795 7780010 54.55 µM 4.94292677510057 1.85535385876935e-07 yes 4 3.84791974939187e-07 9 953673
SGTC_1031 k035-0009 16 µM 4.81131942294737 3.70074239340193e-07 yes 5 7.49685826784289e-07 12 5180959
SGTC_2835 9006588 71.43 µM 4.57717316462641 1.21201792411643e-06 yes 6 2.35650657982146e-06 26 2345538
SGTC_1787 fluconazole 80 µM 4.55763924513543 1.33486148796289e-06 yes 7 2.58658966084766e-06 15 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_61 0978-8327 98.565 µM 4.46537890645381 2.0954034373323e-06 yes 8 3.99635848258233e-06 20 6150059 YHR072W ERG7
SGTC_2800 7887935 81.82 µM 4.45876874626632 2.16351246978582e-06 yes 9 4.12158984474138e-06 14 2961002
SGTC_1616 st002734 56.1 µM 4.18090544926755 7.98609029957942e-06 yes 10 1.45175293856461e-05 24 4026101
SGTC_2581 avocatin a 64 µM 4.08337540493038 1.2406725336899e-05 yes 11 2.21931160249543e-05 48 6710728 A skin care supplement.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 4.01314705131031 1.6940770196844e-05 yes 12 2.99572810494907e-05 46 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2290 7904846 200 µM 3.96488656887026 2.09260373875962e-05 yes 13 3.67154285259199e-05 20 2962154
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 3.82823956816281 3.75974301995673e-05 yes 14 6.4531550044556e-05 16 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_519 k048-0011 62.8 µM 3.8268291360434 3.78219356971531e-05 yes 15 6.49022747202329e-05 26 6836379
SGTC_1939 st074455 53.6 µM 3.76799076754043 4.84016725428414e-05 yes 16 8.22833937166523e-05 34 1644229
SGTC_3108 9121785 49.47 µM 3.71155222010614 6.11281508659453e-05 yes 17 0.000102996079409726 18 17140271
SGTC_948 3448-0295 75.3 µM 3.66930210217516 7.26541401252858e-05 yes 18 0.000121606764943916 37 678569
SGTC_1029 k015-0030 64.7 µM 3.6601300382721 7.54131940665964e-05 yes 19 0.000126043641767618 41 2208316
SGTC_788 1182-0090 188 µM 3.61474670848766 9.05777513206461e-05 yes 20 0.000150320703649485 94 5715185
SGTC_175 3793-3120 23.7 µM 3.54997799542883 0.000117244340724641 yes 21 0.000192631676227229 24 5322297
SGTC_2658 polymyxin b sulfate 77.05 µM 3.52242013845107 0.000130690348313487 yes 22 0.000213812929566992 58 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2789 5281112 71.43 µM 3.51022311903503 0.000137091754005656 yes 23 0.000223865414913614 58 765948
SGTC_3173 9105693 49.47 µM 3.4637274070977 0.000164289357466301 yes 24 0.000266373038998922 39 17096658
SGTC_953 1188-0045 9.7 µM 3.41304425045408 0.000199644948070951 yes 25 0.000321207550493288 46 6144426
SGTC_2600 tangeritin 87.95 µM 3.38853905240612 0.000219180425739528 yes 26 0.000351330111085297 56 68077 A bioactive flavone.
SGTC_3281 9140613 49.47 µM 3.31780590487385 0.000286039407297162 yes 27 0.000453637533357239 39 16013766
SGTC_2768 sulfasalazine 50.2 µM 3.30273482562564 0.000302546983161692 yes 28 0.000478734416608306 39 5384001 An antioxidant and salicylic acid derivative.
SGTC_310 1273-0058 1.06 µM 3.30234430598023 0.000302986281183844 yes 29 0.000479401497485181 312 2734232
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 3.29377677640812 0.000312774601489444 yes 30 0.000494254836865216 50 688664
SGTC_931 2812-0076 566 µM 3.26608585601066 0.000346459973325771 yes 31 0.000545225912705679 53 3450959
SGTC_227 fluconazole 33.516 µM 3.25295300268207 0.000363587849435201 yes 32 0.000571061927272672 124 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2150 5556613 200 µM 3.22325421802721 0.00040526225653281 yes 33 0.000633715075193729 40 743190
SGTC_3175 9106517 49.47 µM 3.19590917072057 0.00044751175831767 yes 34 0.000696954923633643 40 41468073
SGTC_3132 9126706 49.47 µM 3.18889203944291 0.000458993367610613 yes 35 0.000714096026854736 56 850858
SGTC_2035 5154463 94.595 µM 3.16007663762109 0.000509062784353024 yes 36 0.000788638224997571 44 2769623
SGTC_2896 9052656 71.43 µM 3.14998927939626 0.000527753212012036 yes 37 0.000816382269471583 186 6469436
SGTC_1637 st007924 17.4 µM 3.13278895495301 0.000561093702805163 yes 38 0.000865769481090357 58 683336
SGTC_2582 agaric acid 100 µM 3.12377203980548 0.000579339780440074 yes 39 0.000892743640513096 412 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2891 9063876 19.48 µM 3.0917447629598 0.00064867301814996 yes 40 0.000994919306114263 22 6472478
SGTC_55 0767-0285 6.563 µM 3.05748848067441 0.00073124994949697 yes 41 0.00111600109999166 82 3116166
SGTC_176 1486-1328 72.834 µM 3.0395169278574 0.000778347151732932 yes 42 0.0011847894285832 110 22310231
SGTC_2452 5863136 48.41 µM 3.03718105683871 0.000784669689754699 yes 43 0.00119400985390058 65 2184096
SGTC_2440 5628896 157.78 µM 3.02316327799839 0.000823615767182061 yes 44 0.001250736184773 49 5522048
SGTC_3128 9127691 49.47 µM 3.00443273869131 0.000878433377345443 yes 45 0.00133038291552826 50 41316314
SGTC_1301 naphtanilide LB 4.81 µM 2.98389030753869 0.000942396782996809 yes 46 0.00142304392120147 43 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2855 9016525 58.44 µM 2.97985918228948 0.000955440023308911 yes 47 0.00144190459771768 69 43811474
SGTC_579 4491-1009 110 µM 2.97298692949495 0.000978058925368984 yes 48 0.00147458504894622 74 1271041
SGTC_520 3584-0023 682 µM 2.96845633204363 0.000993238417557333 yes 49 0.00149649812969768 70 1340790
SGTC_62 0180-0423 3.232 µM 2.95878968292404 0.00102635137085542 no 50 0.00154424903899807 62 30102 YGL099W LSG1
SGTC_234 nsc-17383 10.7 µM 2.95307176690175 0.00104641166959339 no 51 0.00157314403606784 61 408974
SGTC_2701 st077767 14.721 µM 2.92652473225971 0.00114434234970809 no 52 0.0017138612525605 103 5721188
SGTC_2307 7538926 6.34 µM 2.90850350458067 0.00121553131798579 no 53 0.00181581553023974 99 96582
SGTC_120 rhodamine 6G 52.259 µM 2.90209886658875 0.00124179227824823 no 54 0.00185335768346672 103 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2845 9003024 42.97 µM 2.8710957168977 0.00137640548592851 no 55 0.00204525822333918 108 2990173
SGTC_2218 6965428 192.983 µM 2.8245697538162 0.0016035526401202 no 56 0.00236720709308945 36 675684
SGTC_2988 9073640 71.4286 µM 2.81705671197896 0.00164328212186199 no 57 0.00242329834609362 68 9102229
SGTC_2235 salicylic acid 500 µM 2.80256534938989 0.00172245612373373 no 58 0.00253489720780554 24 338 A COX inhibitor and kinase inhibitor.
SGTC_1156 4092-0367 4.88 µM 2.79309092330281 0.00177608085628565 no 59 0.00261035076425349 79 1357585
SGTC_1605 st000082 49.1 µM 2.78066402718331 0.00184871841104204 no 60 0.00271239234858538 78 1114022
SGTC_670 4204-0025 119 µM 2.76695217307565 0.00193199284016814 no 61 0.00282915277746574 91 719039
SGTC_1286 0929-0070 131 µM 2.76662617805736 0.00193401349244179 no 62 0.00283198307665081 93 1420408
SGTC_1129 3453-1384 223 µM 2.76356972719798 0.00195305223484245 no 63 0.00285864377160583 118 1084452
SGTC_3111 9122088 49.47 µM 2.71003965574652 0.00231528853917148 no 64 0.00336375820690894 35 16876704
SGTC_233 rapamycin 362 pM 2.67874167898589 0.00255426627314428 no 65 0.00369496904061611 61 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1455 4262-0120 131 µM 2.67234937818597 0.00260573449291194 no 66 0.00376610902588446 104 1529587
SGTC_584 0986-0246 15.4 µM 2.65345644475407 0.00276337590627327 no 67 0.00398360260613454 83 53315 YDR232W HEM1
SGTC_2856 9022925 19.48 µM 2.64836194148262 0.00280733241355023 no 68 0.00404414389890165 109 4944862
SGTC_1238 0333-0287 48.8 µM 2.64615338007259 0.00282658362462116 no 69 0.00407064464171915 105 7226
SGTC_1722 st034304 3.6505 µM 2.63375798650267 0.00293685625172694 no 70 0.00422228275870828 130 4036148 YLR033W RSC58
SGTC_2443 5493264 126.67 µM 2.63138916030772 0.00295836604998775 no 71 0.00425183001467088 98 5340055
SGTC_523 1934-0222 13.7 µM 2.61365586089749 0.00312395356289261 no 72 0.00447896075327741 114 1361595
SGTC_3295 9122362 53.5725 µM 2.59438623258046 0.00331330555660756 no 73 0.00473799844285788 86 4730473
SGTC_3317 9138495 8.753 µM 2.58865641761576 0.003371566543655 no 74 0.00481755883744076 108 17020139
SGTC_271 rotenone 740 µM 2.56144215927345 0.00366104726706023 no 75 0.00521192984774734 122 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2313 7726885 200 µM 2.55249689580009 0.00376095753204083 no 76 0.00534769313020276 118 726423
SGTC_1357 1503-1303 39.5 µM 2.54895423837822 0.00380119685892524 no 77 0.00540232384657692 140 292895
SGTC_622 1348-1566 26.3 µM 2.54115361763939 0.00389116385270942 no 78 0.00552436815920526 112 7340407
SGTC_3302 9125395 16.351 µM 2.5372034880609 0.00393744567538406 no 79 0.00558709910058398 95 17599668
SGTC_1768 st044301 37.178 µM 2.51016847889554 0.00426765875640999 no 80 0.00603367859811149 114 3931349
SGTC_2336 9001819 198.65 µM 2.49233700762967 0.00449879612991489 no 81 0.00634527808976701 172 2989602
SGTC_2247 cerulenin 830 nM 2.49110022752104 0.00451523474120246 no 82 0.00636740949296178 107 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_692 k241-0027 77.8 µM 2.48126309906971 0.00464790595970027 no 83 0.00654588508435563 94 3600480
SGTC_2994 9053520 71.4286 µM 2.47928671515586 0.00467497687452926 no 84 0.00658227183247345 102 4647384
SGTC_533 1222-0222 6.71 µM 2.4719051530578 0.00477733159727628 no 85 0.00671975837740992 131 3982874
SGTC_686 1319-0111 510 µM 2.45723021136873 0.00498677171883337 no 86 0.00700064658072187 120 4562600
SGTC_2193 5925765 200 µM 2.45395421429863 0.00503462867299602 no 87 0.00706474852585757 75 877370
SGTC_2149 5554786 194.827 µM 2.45272501743143 0.00505269047910382 no 88 0.00708893371505037 160 745063 YPR165W RHO1
SGTC_1631 benzylvanillin 81.9 µM 2.43969063722298 0.00524779692399521 no 89 0.00734992216597771 137 75506
SGTC_2858 9025781 8.96 µM 2.43209491665315 0.00536455977472596 no 90 0.00750588641393547 251 4894980 YPL153C RAD53
SGTC_1055 3448-0672 86 µM 2.42577538129557 0.00546345923927757 no 91 0.00763786076665419 145 748378
SGTC_2834 9001755 58.44 µM 2.425036362115 0.0054751299202567 no 92 0.00765342676017084 134 2989575
SGTC_1016 4226-1401 38 µM 2.42184765101385 0.00552574084267388 no 93 0.00772091140056984 138 2901613
SGTC_1039 k821-0043 94 µM 2.41468260234303 0.00564098287274377 no 94 0.00787446333711973 135 15992768
SGTC_1120 ficusin 1.78878 µM 2.4107303557732 0.00570545949134003 no 95 0.00796030700061851 123 6199 A DNA cross-linker.
SGTC_3201 9113999 49.47 µM 2.39397944233213 0.00598605235277054 no 96 0.00833334145543971 149 16649224
SGTC_1204 4049-0315 18.3 µM 2.39270205439253 0.00600794351671694 no 97 0.00836240819119302 144 588402
SGTC_2773 thioridazine 9.09 µM 2.36636181518524 0.00647544504173295 no 98 0.0089819394622218 114 5452 An antipsychotic.
SGTC_985 1493-0307 8.71 µM 2.35808281755511 0.00662889020672127 no 99 0.00918479713056284 94 3278274
SGTC_2952 9073731 13.78 µM 2.35766273865644 0.00663676105064046 no 100 0.00919519625931769 191 16457353
SGTC_867 0518-0118 155 µM 2.33883111011536 0.00699819649237354 no 101 0.00967208797978659 140 6848158
SGTC_3044 9093193 49.47 µM 2.33677881795454 0.00703861735888975 no 102 0.00972534389063254 167 25236277
SGTC_2001 4023502 57.655 µM 2.33243861670071 0.00712477892000489 no 103 0.0098388142924776 156 108941 YCR052W RSC6
SGTC_3030 9087619 49.47 µM 2.32706275634939 0.00723278948653299 no 104 0.00998096269120413 136 25236973
SGTC_705 1124-0212 310 µM 2.31182615861821 0.00754680485549843 no 105 0.0103936326304709 141 9554485
SGTC_937 3122-0005 46.7 µM 2.31026397791838 0.007579669180964 no 106 0.0104367719670723 161 759535
SGTC_1665 st014639 11.4 µM 2.30971000542486 0.00759135359327681 no 107 0.0104521072555057 167 981133 YIL048W NEO1
SGTC_2095 5432005 200 µM 2.30839883189183 0.00761907214172174 no 108 0.010488481955026 116 783734
SGTC_3127 9126946 49.47 µM 2.29563392326252 0.00789361672138832 no 109 0.0108484107160514 121 27243249
SGTC_3265 9137266 49.47 µM 2.29016658543482 0.00801384395213526 no 110 0.0110058308229995 101 17224265
SGTC_1646 st011709 75.6 µM 2.27250182678723 0.00841336704044904 no 111 0.0115281088935134 113 5757843
SGTC_3008 9078912 71.4286 µM 2.25281634869182 0.0088790946704935 no 112 0.0121353654707899 141 16648731
SGTC_2729 fluphenazine 10.66 µM 2.25217988575925 0.00889452218535091 no 113 0.0121554532942094 159 3372 An atypical antipsychotic.
SGTC_1105 epirubicin 18.1 µM 2.24383010598449 0.00909910220811517 no 114 0.0124216672829984 143 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2837 9008476 45.46 µM 2.240215565403 0.00918893322674791 no 115 0.0125384658148671 194 2992805
SGTC_715 0868-0130 184 µM 2.23420448393852 0.00934004425535042 no 116 0.0127348107734291 118 2876258
SGTC_3085 9117376 49.47 µM 2.23319994133653 0.00936550808627264 no 117 0.0127678811013088 142 16480349
SGTC_2325 6158266 200 µM 2.23249721657861 0.00938335731416711 no 118 0.0127910594929681 164 3623240
SGTC_522 1273-0010 11.6 µM 2.22981883465343 0.00945166141279922 no 119 0.0128797362416097 163 5705015
SGTC_3320 9137005 35.139 µM 2.22176510846604 0.00965967371304843 no 120 0.0131495919348514 146 4908713
SGTC_2572 astragaloside iv 100 µM 2.21612601314604 0.00980769168352617 no 121 0.0133414365775875 190 45006101 An anti-inflammatory agent.
SGTC_539 4859-0462 2.54 µM 2.20832098403528 0.0100158289923136 no 122 0.0136109527801687 166 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2184 6075246 200 µM 2.18906985684775 0.0105457580651603 no 123 0.0142958815111237 157 2267320
SGTC_885 0865-0106 16.8 µM 2.18722032667895 0.0105979339357949 no 124 0.0143632218508326 199 2793380
SGTC_1400 3771-8998 51.5 µM 2.18602776459999 0.0106316956320938 no 125 0.0144067870484413 105 670767
SGTC_1511 0906-3109 28.5 µM 2.18395731645588 0.0106905330128936 no 126 0.0144826923322524 257 2882180
SGTC_3027 9089541 49.47 µM 2.1554018317061 0.0115314023207917 no 127 0.0155652015799208 191 9943819
SGTC_2755 lomerizine 42.69 µM 2.1538652409846 0.0115782352916007 no 128 0.0156253707689563 196 3949 A calcium channel blocker.
SGTC_1260 0700-1617 7.75 µM 2.14143503332255 0.0119631989830303 no 129 0.0161194861515444 222 2853078
SGTC_2690 usnic acid 100 µM 2.13344845181467 0.0122163596354078 no 130 0.0164439780114238 218 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_292 k038-0015 474 µM 2.12726895416332 0.0124154122442959 no 131 0.0166988713699927 165 46368540
SGTC_1338 1486-1223 76 µM 2.1224353893116 0.0125730620069806 no 132 0.0169005965047225 192 3444526
SGTC_189 3970-0742 2.116 µM 2.12124429493743 0.0126121753890927 no 133 0.016950624728497 124 2891807
SGTC_2019 4016004 108 µM 2.11363313591758 0.0128646073725195 no 134 0.0172733067096729 192 45595336
SGTC_967 1306-0166 352 µM 2.08981585462772 0.0136829635058203 no 135 0.018317172290863 216 4437607
SGTC_3279 9140807 49.47 µM 2.08253681991519 0.0139418667367589 no 136 0.0186467316708374 155 45595718
SGTC_2627 acetyl isogambogic acid 100 µM 2.08015387043792 0.0140275369494355 no 137 0.0187557109002004 223 6857789 A caspase activator and apoptosis inducer.
SGTC_830 4076-0286 57.8 µM 2.07873368583338 0.0140788099690651 no 138 0.0188209174993833 365 6866659
SGTC_2850 9015429 58.44 µM 2.02909449032336 0.0159752635762932 no 139 0.0212243334949496 204 6457570
SGTC_299 1273-0059 1.44 µM 2.02315559740607 0.0162161960315606 no 140 0.0215285539747109 189 2848077
SGTC_1886 st057356 49.9 µM 2.01614303332167 0.0165046874305438 no 141 0.0218925106313841 200 24207747
SGTC_475 α-linolenic acid 10 µM 2.00110755070405 0.0171380721166753 no 142 0.0226904004075573 231 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1232 0279-0259 161 µM 1.99545659270837 0.0173814374066231 no 143 0.0229965519440856 224 1560000
SGTC_2692 st077426 47.7 µM 1.99398670113236 0.0174452216271634 no 144 0.0230767539422922 226 25238571
SGTC_660 4031-1742 102 µM 1.98021755430558 0.0180524832232238 no 145 0.0238395440893546 269 6738706
SGTC_2052 5265182 7.135 µM 1.9684652860201 0.0185849610009816 no 146 0.0245072632514122 244 1239884
SGTC_1615 st002656 86.5 µM 1.95894828437216 0.0190259062017226 no 147 0.0250594217839119 209 1584458
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.94562000022058 0.0196583694362311 no 148 0.0258502013678185 109 279621
SGTC_1235 benzylparaben 21.5 µM 1.94492935182423 0.0196916233848738 no 149 0.0258917409018376 223 7180
SGTC_1895 st058434 18.3 µM 1.94406659284284 0.0197332313469723 no 150 0.0259437105959401 227 5393175
SGTC_932 2857-0803 154 µM 1.93877588588319 0.0199900197643587 no 151 0.0262643168152044 240 674898
SGTC_208 k072-0098 12.366 µM 1.93542667114337 0.0201540373317253 no 152 0.0264689795161725 315 5948901
SGTC_3292 9120825 59.784 µM 1.93216147067553 0.0203150377846549 no 153 0.0266697895525059 229 24824900
SGTC_435 c-PAF 6.7 µM 1.93033797215104 0.0204054243325228 no 154 0.0267824875106031 274 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1442 4112-3290 3 µM 1.92597762792019 0.0206229391334786 no 155 0.0270535836874794 249 704353
SGTC_105 0111-0055 734.78 µM 1.91993218543535 0.0209277613904302 no 156 0.0274332329173916 184 5179370
SGTC_1270 0831-1170 17.3 µM 1.91937636441052 0.0209559773510345 no 157 0.0274683599705339 236 6764716
SGTC_525 k781-2675 26.7 µM 1.91501877910109 0.0211783055374083 no 158 0.0277450543777034 288 3651118 YDL195W SEC31
SGTC_1830 st055982 50.3 µM 1.91264424605625 0.0213002941258285 no 159 0.0278968056247281 254 455313 An antimicrobial agent.
SGTC_2736 butenafine 14.65 µM 1.91128036325145 0.021370630144524 no 160 0.0279842805916313 285 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2466 5983409 37.09 µM 1.91066153049943 0.0214026083203964 no 161 0.0280240457684414 232 2879657
SGTC_1296 1068-0102 11.9 µM 1.89529905395022 0.0222095277631274 no 162 0.0290263967230813 241 767053
SGTC_2196 6573537 42.6665 µM 1.88813803039461 0.0225943474510216 no 163 0.0295037112501319 205 2903087
SGTC_97 0535-0701 19.132 µM 1.88682660877714 0.0226654262647561 no 164 0.0295918254702735 224 2832013 YGL099W LSG1
SGTC_302 1094-0063 18.9 µM 1.8852347332204 0.0227519587897404 no 165 0.0296990767067104 189 5440289
SGTC_2402 5553605 200 µM 1.88509278645987 0.0227596883541696 no 166 0.0297086558899324 274 6758546
SGTC_718 1130-0073 349 µM 1.87158788985451 0.0235052722017452 no 167 0.0306318200521121 276 6740020
SGTC_328 k915-0120 63.5 µM 1.86478199731259 0.0238887353492114 no 168 0.031105983859504 258 6624543
SGTC_572 0960-0087 17.7 µM 1.86199428471087 0.0240473139159802 no 169 0.0313019479180825 329 6796365
SGTC_2539 epi(13)torulosol 80 µM 1.85880870819287 0.0242296067897453 no 170 0.0315271288465084 269 6708597
SGTC_2431 5490079 200 µM 1.85008186319862 0.0247349494109993 no 171 0.0321508757812037 270 5722345
SGTC_2570 licareol 100 µM 1.84783150017174 0.0248666850669323 no 172 0.0323133612214441 280 443158
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.84599834638858 0.0249744318181776 no 173 0.0324462227674833 293 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2062 5245942 200 µM 1.84265922022148 0.0251717005812126 no 174 0.0326893907953655 291 1376160
SGTC_641 4092-0595 30 µM 1.83641459295294 0.0255441255011918 no 175 0.033148181470602 276 786260
SGTC_449 xestospongin c 11.1929 µM 1.83153175437573 0.0258385389226391 no 176 0.033510606275943 322 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_727 3032-0951 202 µM 1.83080701173601 0.0258824787467435 no 177 0.0335646767070085 258 3652836
SGTC_3054 9094397 49.47 µM 1.83050771136269 0.0259006430148088 no 178 0.0335870273692258 307 2598354
SGTC_1395 3486-0190 4.35 µM 1.82808146041473 0.0260482840138286 no 179 0.0337686634676913 278 6748079
SGTC_591 4299-0174 154 µM 1.82447183516506 0.0262692372662389 no 180 0.0340403852746703 241 5509088
SGTC_2233 sulbentine 40.3845 µM 1.82445930276822 0.0262700071232942 no 181 0.034041331798814 345 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1604 st002052 72.4 µM 1.81688822619908 0.0267385534819671 no 182 0.0346171149226737 277 6254834 YHR062C RPP1
SGTC_136 0097-0015 404.482 µM 1.80781862613993 0.0273090054088236 no 183 0.0353173669250286 302 4861337
SGTC_704 1310-0270 142 µM 1.80759128860072 0.0273234337000454 no 184 0.0353350675285311 335 5718033
SGTC_1330 1469-0054 61.8 µM 1.80691693849479 0.0273662696676028 no 185 0.0353876155378689 256 7102664
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.80465817930645 0.0275101584047518 no 186 0.0355640939403367 286 6312947
SGTC_868 0527-0199 213 µM 1.80007475596754 0.0278040731249161 no 187 0.0359244175145306 302 2849450
SGTC_3166 9102297 49.47 µM 1.7898910141225 0.0284664838460631 no 188 0.0367357168499833 318 25237072
SGTC_2678 equilin 100 µM 1.78720464305912 0.0286433935823326 no 189 0.0369522095817045 296 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1049 3226-0134 66 µM 1.78510431510344 0.0287823457887105 no 190 0.0371221990933108 325 5702385
SGTC_2607 solasodine 47.35 µM 1.77525155842721 0.0294416799962157 no 191 0.037928180003442 343 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2931 9014674 55.67 µM 1.77419099384387 0.0295133933172208 no 192 0.0380157817061152 308 2996810
SGTC_1715 st032160 10.2275 µM 1.77186036047169 0.0296714957548543 no 193 0.0382088699427755 281 5289825
SGTC_3316 9136639 10.545 µM 1.76862255045423 0.0298923038852115 no 194 0.0384784424649784 273 4903665
SGTC_2569 tetrandrine 100 µM 1.7662378108766 0.0300558055398866 no 195 0.0386779800179122 259 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3349 9149703 23.001 µM 1.76158192401465 0.0303771580601541 no 196 0.0390699801016085 277 4910494
SGTC_576 1073-0113 22.7 µM 1.75336872071951 0.0309509780911703 no 197 0.0397693682502413 461 5439563
SGTC_2958 9077254 16.72 µM 1.74971451004577 0.0312091497995141 no 198 0.0400837943253022 301 16457351
SGTC_2725 haloperidol 53.21 µM 1.73518654132755 0.0322532356444555 no 199 0.0413538847826251 329 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1740 st038286 13.222 µM 1.73466395543509 0.0322913232306379 no 200 0.0414001721017576 322 716786
SGTC_881 0833-0569 170 µM 1.73437664138716 0.0323122793265144 no 201 0.0414256384270351 334 5418700
SGTC_3293 9120939 62.045 µM 1.73251541990528 0.0324483049908108 no 202 0.0415909170125866 290 934087
SGTC_2665 lovastatin 100 µM 1.73064194280076 0.0325857030984825 no 203 0.041757823014583 291 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1437 4092-1038 11.6 µM 1.7273690410092 0.0328268842082992 no 204 0.0420507035004225 325 3977136
SGTC_1705 st027868 56.3335 µM 1.72721330344632 0.0328383971357258 no 205 0.0420646812447436 273 292948
SGTC_892 0929-0076 29 µM 1.72271798193141 0.0331721518678778 no 206 0.0424697684507959 382 5751038
SGTC_308 4092-1169 104 µM 1.72260096441137 0.0331808770021918 no 207 0.0424803552440528 350 2268590 YDL196W YDL196W
SGTC_278 4092-0821 23.9 µM 1.71729059699785 0.0335788259267451 no 208 0.0429630446176928 302 877900
SGTC_3167 9103034 49.47 µM 1.71221091672204 0.0339631555741578 no 209 0.0434289031804353 225 5127859
SGTC_2584 androsterone 48.74 µM 1.69475282191694 0.0353117130581286 no 210 0.0450611603209946 497 2754130 A steroid.
SGTC_2421 5690543 90.72 µM 1.6946311554077 0.0353212631322398 no 211 0.0450727065024312 322 3397993
SGTC_1698 5-fluorocytosine 1.055 µM 1.69419903184567 0.0353551993039393 no 212 0.0451137343808532 298 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_203 k066-0004 30.888 µM 1.68750167705317 0.035884593298411 no 213 0.0457534638617246 411 6795412
SGTC_863 0466-0191 129 µM 1.68571913749666 0.0360265836191446 no 214 0.0459249545075259 388 765160 YPR165W RHO1
SGTC_2505 galangin 7.89 µM 1.67738641491352 0.0366964521953632 no 215 0.0467334720748989 249 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1161 k007-0610 110 µM 1.67508761579168 0.0368830353663508 no 216 0.046958521207187 455 5843850
SGTC_1256 0570-0116 285 µM 1.6748335325202 0.0369037056816016 no 217 0.0469834488430721 310 410638
SGTC_2654 protoveratrine a 100 µM 1.66314016739642 0.0378652857571569 no 218 0.0481421905536715 311 5702278 A heart drug and vasodilator.
SGTC_401 neomycin 50 µM 1.66091337862921 0.038050698790737 no 219 0.048365422454629 296 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3203 9113543 49.47 µM 1.65921179887493 0.038192879055565 no 220 0.0485365604369188 359 17018012
SGTC_184 1494-0393 24.714 µM 1.65230310523537 0.0387746112966218 no 221 0.0492363883074197 383 3090647
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.6518846350414 0.0388100782889925 no 222 0.0492790354411751 362 688801
SGTC_1614 st002383 48.6 µM 1.64776746885976 0.0391604350535062 no 223 0.0497001984983192 347 1947235
SGTC_1391 3442-0225 151 µM 1.64447047406813 0.0394428505581436 no 224 0.0500395291719534 282 5227075
SGTC_596 1155-0152 116 µM 1.63319269218991 0.0404214382545545 no 225 0.0512142382294147 425 280313
SGTC_199 4063-0024 41.6 µM 1.63294372890769 0.0404432615265744 no 226 0.0512404160106256 316 306215
SGTC_2975 9084847 53.72 µM 1.62448600801213 0.0411903369740458 no 227 0.0521360621041078 372 27211724
SGTC_2437 5741531 144.16 µM 1.6238182443881 0.0412497943844401 no 228 0.0522073025478603 381 2262990
SGTC_1464 k208-0027 110 µM 1.62301069627963 0.0413217910770423 no 229 0.0522935591733607 366 X1464
SGTC_2254 7938975 95.19 µM 1.61645554052581 0.0419099901888293 no 230 0.0529979292134251 445 2969277
SGTC_2903 5923464 63.88 µM 1.61449562497356 0.0420871654217173 no 231 0.0532099825246109 300 2876576
SGTC_3250 9135583 49.47 µM 1.60970841333934 0.0425224760667991 no 232 0.0537307636934368 310 7699353
SGTC_93 0109-0045 59.227 µM 1.60918483136282 0.0425703065086897 no 233 0.0537879660948979 468 88733
SGTC_2089 5281248 129.67 µM 1.60864102657984 0.0426200303989247 no 234 0.0538474289246619 369 2737878
SGTC_1991 st073000 8.92 µM 1.60411377529307 0.0430358139547734 no 235 0.0543444880053856 440 4301969 YIL048W NEO1
SGTC_2560 caryophyllene 100 µM 1.60308734107363 0.0431305361058856 no 236 0.0544576862108333 411 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2210 7115885 190.385 µM 1.59776965475867 0.0436239661678616 no 237 0.0550471251904547 360 2927039
SGTC_1366 1683-0113 21.9 µM 1.58843658033265 0.0445009919848836 no 238 0.0560938256094942 351 708623
SGTC_2368 9071271 200 µM 1.58715952747101 0.044622093428543 no 239 0.0562382592967535 378 27209959
SGTC_849 0386-0493 241 µM 1.58523166839038 0.044805412755606 no 240 0.0564568538908241 358 726119
SGTC_1737 st035557 69.7 µM 1.57731127237694 0.0455649324417562 no 241 0.0573619599618584 319 5716916
SGTC_2025 5147754 141 µM 1.56959440920725 0.0463148571909444 no 242 0.0582547500081244 343 315777 YLR208W SEC13
SGTC_1574 spiramycin 23.7 µM 1.56929928712378 0.0463437327296821 no 243 0.0582891091760516 406 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_706 4262-0057 46.9 µM 1.56679883872618 0.0465889637323818 no 244 0.058580859467101 389 883298
SGTC_3313 9133968 57.047 µM 1.56419591155362 0.0468453504575617 no 245 0.0588857835346934 401 1494643
SGTC_942 3253-1115 227 µM 1.56096224506185 0.0471654395677291 no 246 0.0592663296308118 386 46497897
SGTC_632 0781-2353 4.65 µM 1.56029401939671 0.0472318029316296 no 247 0.0593452080246907 417 6811515 YHR007C ERG11
SGTC_1289 0976-0073 69.1 µM 1.55339275745457 0.0479215731607618 no 248 0.0601646660591752 395 3391136
SGTC_2366 9070441 60.58 µM 1.54729618222118 0.0485376030081358 no 249 0.0608959209656482 409 6837235
SGTC_943 3253-1379 105 µM 1.54719670462174 0.0485477070005355 no 250 0.0609079101888119 387 668464
SGTC_322 k048-0136 19.3 µM 1.54603507640479 0.0486658187150277 no 251 0.0610480483951652 376 6823282
SGTC_2610 ononetin 44.17 µM 1.53796409222361 0.0494928129982134 no 252 0.0620286973552289 457 259632
SGTC_3193 9111931 49.47 µM 1.53511873612132 0.0497870229924957 no 253 0.0623773324054324 403 17087244
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.53382845448655 0.049920897176475 no 254 0.0625359304133129 415 165521
SGTC_964 1287-0107 19.4 µM 1.52213861206927 0.0511469095543409 no 255 0.0639871764495711 445 51516812 YPR165W RHO1
SGTC_124 0136-0217 7.121 µM 1.52018978824971 0.0513536099018028 no 256 0.0642316415873364 487 3976905
SGTC_2329 6138490 200 µM 1.51705592264386 0.0516873934973595 no 257 0.0646262827299067 391 720019
SGTC_3275 9138069 49.47 µM 1.51403833601382 0.0520104200025305 no 258 0.0650080583560813 376 17617007
SGTC_1304 1165-0502 251 µM 1.51064466606743 0.0523756194478819 no 259 0.0654395037147838 480 767425
SGTC_2727 riluzole 51.77 µM 1.51060171476645 0.0523802545344157 no 260 0.0654449784132183 359 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1038 k292-0204 154 µM 1.50832810062931 0.0526260766789811 no 261 0.0657352873234253 392 4454212
SGTC_2473 5854593 8.94 µM 1.50730813091994 0.0527366524192595 no 262 0.0658658472065468 374 2872951
SGTC_2464 5717415 7.67 µM 1.50276759918838 0.0532311336997085 no 263 0.0664494919440992 438 5285744
SGTC_3351 9150312 21.596 µM 1.50042269238665 0.0534879383737035 no 264 0.0667524725207653 436 4904905
SGTC_2831 7999036 19.48 µM 1.5001143034428 0.0535217847960448 no 265 0.0667923982308674 450 2988270
SGTC_3234 9132280 49.47 µM 1.49783305347609 0.0537726847386051 no 266 0.0670883153746701 447 17612295
SGTC_1402 3909-7673 35.9 µM 1.49308909950464 0.0542974236410629 no 267 0.0677069327504222 407 5328014
SGTC_1015 4130-4525 82 µM 1.49176559587765 0.0544445397351994 no 268 0.0678803030252878 440 1363237
SGTC_192 3455-0609 60.9 µM 1.49117955068216 0.0545097831271207 no 269 0.0679571805200596 414 3769639
SGTC_504 lovastatin 124 µM 1.49104661484555 0.0545245912429755 no 270 0.0679746284137368 345 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2959 9079155 11 µM 1.48863873382668 0.0547933633118653 no 271 0.0682912630552463 373 16189457
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.48841464427196 0.0548184297712773 no 272 0.0683207884693386 488 676296 Flavone; oxidizing agent.
SGTC_3006 9075424 71.4286 µM 1.48645021336091 0.0550385574661125 no 273 0.0685800382280167 414 7465181
SGTC_122 0236-0016 402.397 µM 1.48628006676862 0.0550576563552357 no 274 0.0686025284621501 504 6808838
SGTC_1982 st072467 71.9 µM 1.48307266163231 0.0554186669721711 no 275 0.0690275532749397 495 3163533
SGTC_324 1315-0088 19.6 µM 1.48252574666876 0.0554804112832899 no 276 0.0691002290471901 362 6787421
SGTC_767 0929-0023 86 µM 1.48157717505827 0.0555876296481724 no 277 0.0692264180153213 544 1204563
SGTC_595 3909-8003 73.7 µM 1.48026133820381 0.0557366312345556 no 278 0.0694017583340552 431 699517
SGTC_2027 5150920 200 µM 1.47941510496384 0.0558326226602913 no 279 0.0695147027654564 404 786715
SGTC_1904 st060225 78 µM 1.47672813995568 0.0561382800266886 no 280 0.0698742629404906 414 66595
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.47248910227831 0.0566231755433232 no 281 0.0704444238469335 443 5282309
SGTC_1935 st074532 41.6 µM 1.47236571093022 0.0566373393152804 no 282 0.0704610736973105 518 2829742
SGTC_3016 9080866 49.47 µM 1.47043960599793 0.0568587939335254 no 283 0.0707213656323179 456 17066299
SGTC_1078 idebenone 36.1 µM 1.46276600320338 0.0577478461930683 no 284 0.0717657093094445 506 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_492 tmb-8 126 µM 1.45909635082912 0.0581768523264996 no 285 0.0722692952414502 273 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2347 9049783 174.81 µM 1.45615656964325 0.0585223349731867 no 286 0.0726746711694991 482 6467988 YPL169C MEX67
SGTC_2860 9025725 38.96 µM 1.45053965457767 0.0591869113930195 no 287 0.0734540447014891 394 40546248
SGTC_1071 trifluoperazine 6.31 µM 1.44381355558761 0.0599904939453677 no 288 0.0743957139306724 479 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_490 phenamil 164 µM 1.44330164456016 0.0600520013287477 no 289 0.0744677583628091 329 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_557 1315-0110 16.2 µM 1.44308136257594 0.0600784839487744 no 290 0.074498776406294 451 6833801
SGTC_2691 st077356 60.2 µM 1.44173332480063 0.0602407462646578 no 291 0.0746888093396043 462 2839272
SGTC_3157 9099274 49.47 µM 1.43871293644677 0.060605553488563 no 292 0.0751159362735446 416 17217662
SGTC_697 0508-1955 564 µM 1.4371393068009 0.0607963024806913 no 293 0.0753392071926014 500 6243113
SGTC_2986 9022445 71.43 µM 1.43508559697368 0.0610459506328453 no 294 0.0756313536592828 453 6459286
SGTC_465 cgp-37157 41 µM 1.43260758322012 0.0613482429068979 no 295 0.0759850067020828 318 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_56 0957-0365 83.25 µM 1.42815212230946 0.0618947036247077 no 296 0.0766240389147075 473 6752360
SGTC_2071 5230951 39.92 µM 1.4252168013158 0.0622567906159783 no 297 0.0770472705606629 486 1799272
SGTC_2934 9036370 36.88 µM 1.41747284867294 0.0632199771809155 no 298 0.0781723635561139 494 6462800
SGTC_2793 7325131 81.82 µM 1.41741345185192 0.0632274094951689 no 299 0.0781810410228164 418 4176441
SGTC_344 k064-0035 6.43 µM 1.4171467027699 0.0632607961518417 no 300 0.0782200202360426 460 5088750
SGTC_2293 7624732 200 µM 1.41390679547059 0.0636674037368986 no 301 0.0786946352194528 440 894453
SGTC_649 1123-0311 367 µM 1.40684239690692 0.0645610321681006 no 302 0.0797370637915591 541 693629 YIL048W NEO1
SGTC_247 mechlorethamine 29.705 µM 1.3988080783283 0.0655891610142659 no 303 0.0809352715855437 409 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3083 9117465 49.47 µM 1.39880247802639 0.0655898820707902 no 304 0.0809361115076465 491 16420915
SGTC_755 1995-0008 37.3 µM 1.39870818405049 0.0656020236404151 no 305 0.0809502545180031 483 689533
SGTC_3249 9135183 49.47 µM 1.39755997752259 0.0657500099359967 no 306 0.081122621966809 498 4902779
SGTC_2888 9058547 12.99 µM 1.3919711134081 0.0664740272549948 no 307 0.0819655727553429 395 16476514
SGTC_2463 5473429 200 µM 1.38730848320531 0.0670827639887952 no 308 0.0826738587184163 452 5399405
SGTC_2979 9012552 45.46 µM 1.38509342056253 0.0673734611794009 no 309 0.0830119517432221 419 17100905
SGTC_1166 k206-0078 225 µM 1.37714913326132 0.0684240552696313 no 310 0.084233072334143 533 5404595
SGTC_2268 7933382 153.85 µM 1.37618266538716 0.0685527237061209 no 311 0.0843825437327992 570 935025 YOR257W CDC31
SGTC_2360 9040895 200 µM 1.37447178447834 0.0687809553481124 no 312 0.084647631973919 459 4914414
SGTC_2460 5552655 174.22 µM 1.37266089420484 0.0690231660268236 no 313 0.0849288958278739 498 5401989
SGTC_734 2023-0417 80 µM 1.37057020560216 0.0693036173454487 no 314 0.0852544880625592 508 3935732
SGTC_3071 9117417 49.47 µM 1.36952344224808 0.0694443627354519 no 315 0.0854178560943553 395 45595590 YGL055W OLE1
SGTC_2751 anetholtrithion 17.25 µM 1.36309826956233 0.070313103958863 no 316 0.0864257710411359 509 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1140 3229-1848 2.98 µM 1.3594990908438 0.070803383963686 no 317 0.0869942451922571 481 2849525
SGTC_24 0417-1663 219 µM 1.35811422416429 0.070992728671353 no 318 0.0872137211998878 492 4329390
SGTC_956 1185-0240 191 µM 1.35296559885088 0.0717000819856765 no 319 0.0880333103633649 490 1416193
SGTC_2771 fluoxetine 41.05 µM 1.35227412837354 0.0717954913019134 no 320 0.0881438187806015 476 3386 A selective serotonin reuptake inhibitor.
SGTC_2327 6189656 200 µM 1.34744426219025 0.0724646353674356 no 321 0.0889185966617283 486 5349088
SGTC_1963 st076565 50.3 µM 1.34732863810037 0.0724807126317711 no 322 0.0889372063192719 514 4914280
SGTC_1999 st074831 12.5 µM 1.3458144786055 0.07269150530905 no 323 0.0891811774346608 533 17112523
SGTC_1246 0422-0085 105 µM 1.34342048056829 0.0730257415647853 no 324 0.0895679294277148 571 264295
SGTC_345 1362-0200 395 µM 1.34330653593196 0.0730416791347429 no 325 0.0895863683061478 483 1419823
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.33826933795945 0.0737489011610955 no 326 0.0904043266515801 532 4213774
SGTC_1785 bathophenanthroline 24 µM 1.33771567593132 0.0738269534286826 no 327 0.0904945694633106 536 72812 An iron chelator.
SGTC_1058 3448-5425 97.3 µM 1.3297480375474 0.0749571908472472 no 328 0.0918006508282564 512 7279705
SGTC_1677 st019204 53.9 µM 1.32971925598751 0.0749612974024778 no 329 0.0918053939740337 494 3945625
SGTC_1506 4226-2149 212 µM 1.32732551960985 0.0753034368817828 no 330 0.0922005127996892 576 991114
SGTC_2405 ticlatone 3.52 µM 1.32595791344754 0.0754994440189132 no 331 0.0924268191395841 506 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2943 9068529 45.32 µM 1.32414954627503 0.0757592182299386 no 332 0.0927266916678977 566 3270634
SGTC_2987 9018338 71.43 µM 1.32276164939825 0.0759590527001997 no 333 0.0929573272756546 534 5055682
SGTC_2700 st077718 96.8 µM 1.32068066782962 0.0762594317486077 no 334 0.0933039313597023 483 904970
SGTC_551 k048-0028 34.9 µM 1.31383545434443 0.0772538822269974 no 335 0.0944507917908616 581 6836383
SGTC_688 0527-0193 473 µM 1.31289041535123 0.077391944881748 no 336 0.094609938517183 503 4007154
SGTC_2147 5545932 89.7195 µM 1.30972931544385 0.0778551183181835 no 337 0.0951437113292183 523 797404
SGTC_1623 st003709 20.3 µM 1.30845802953831 0.0780419828036089 no 338 0.095359000603251 617 16192618
SGTC_841 0251-0215 91.2 µM 1.30715300276114 0.07823416054375 no 339 0.0955803766272267 603 3888614
SGTC_2285 7945142 200 µM 1.30414559334859 0.0786783968145433 no 340 0.0960919730177951 530 2970608
SGTC_1416 3966-0321 25.3 µM 1.30170768236361 0.0790399110352955 no 341 0.096508166197024 566 582530 YLR208W SEC13
SGTC_1769 st044406 64.4 µM 1.30091597851234 0.0791575818344247 no 342 0.0966436080801654 592 670903
SGTC_2172 5754775 163.918 µM 1.29808329683689 0.0795796893007592 no 343 0.0971293566642511 513 2263357
SGTC_1951 sophoraflavanone G 9.2 µM 1.29798612788825 0.0795941989286236 no 344 0.0971460509353375 597 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_979 1426-2828 121 µM 1.29405706603491 0.0801825793037532 no 345 0.0978228550421695 582 747872
SGTC_2252 omeprazole 400 µM 1.29366678793277 0.0802412028100133 no 346 0.0978902709961222 436 4594 A proton pump inhibitor.
SGTC_2203 7227154 166.4 µM 1.29293704172113 0.0803509045784265 no 347 0.0980164174265813 500 896304
SGTC_450 aminopyrene 156 nM 1.29102235929116 0.080639274946613 no 348 0.0983479621957222 564 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1860 st056228 74.6 µM 1.28769892061426 0.0811416729558412 no 349 0.0989253947310834 534 688679
SGTC_1848 st056003 16.4 µM 1.28676383943815 0.0812834523075525 no 350 0.0990883071131194 587 146492
SGTC_1752 st044819 83.042 µM 1.28529632508377 0.0815063372076683 no 351 0.0993443769409898 547 441209 YML126C ERG13
SGTC_995 3931-2021 34.6 µM 1.28217230352285 0.0819823455188855 no 352 0.0998911048464548 532 730143
SGTC_371 0195-0006 7.36 µM 1.27694931914329 0.0827828475834459 no 353 0.100810070266585 479 3928593
SGTC_935 2996-0153 430 µM 1.27530464760676 0.0830361322803428 no 354 0.101100716684071 558 23738523
SGTC_2683 piperine 63.03 µM 1.27396843459329 0.0832423421557329 no 355 0.101337301586723 544 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2936 9038235 15.59 µM 1.26708357885949 0.084310947793381 no 356 0.102562703265533 549 4749415
SGTC_1726 st035556 14.5795 µM 1.26673348085321 0.0843655606562411 no 357 0.10262530205821 615 5919439
SGTC_2669 eugenol 100 µM 1.26583514772183 0.0845058158396165 no 358 0.102786054326654 503 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2240 6690706 185.951 µM 1.26528641642946 0.0845915743140474 no 359 0.102884337054216 480 805876
SGTC_578 3460-0051 92 µM 1.26365017552068 0.0848476817764865 no 360 0.103177807887532 635 2876744
SGTC_2030 5175110 200 µM 1.2634434729205 0.0848800765657289 no 361 0.103214924595784 577 2831986
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.26332034410475 0.0848993779332415 no 362 0.103237038921781 554 689007
SGTC_277 nystatin 15.5 µM 1.25640354952988 0.0859889290579261 no 363 0.104484847687364 601 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_732 3970-1727 52.7 µM 1.25581005398223 0.0860829031654815 no 364 0.104592422769123 545 1275699
SGTC_1482 3346-2049 8.48 µM 1.2534093455697 0.0864638155124368 no 365 0.105028386040539 559 3826804
SGTC_3300 9124615 50.48 µM 1.25276904596044 0.0865656222609908 no 366 0.105144884892267 572 24824903
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.25123943025687 0.0868091917122203 no 367 0.10542356819591 559 803109
SGTC_1185 1319-0113 81.3 µM 1.25010673108192 0.0869898876172109 no 368 0.105630280632746 523 4672763
SGTC_1962 st076595 64.5 µM 1.24303136231443 0.0881249619316862 no 369 0.106928138346819 593 279619
SGTC_1171 0368-0077 21.4 µM 1.24096402656767 0.0884586920678138 no 370 0.107309519167516 550 3239779
SGTC_1696 st025591 34.7925 µM 1.24088722694202 0.0884711079515398 no 371 0.107323705982728 600 2787147
SGTC_3273 9137859 49.47 µM 1.24024359805537 0.0885752118612056 no 372 0.107442653516331 560 2377234
SGTC_1513 0337-0559 19 µM 1.23906596675663 0.0887659242962306 no 373 0.107660534688868 533 775073
SGTC_3004 9076122 71.4286 µM 1.23710628000593 0.0890839648624919 no 374 0.108023814310766 595 44782551
SGTC_3017 9080681 49.47 µM 1.23694640412015 0.0891099487339682 no 375 0.108053490415934 585 16451914
SGTC_3036 9090181 49.47 µM 1.23471330670574 0.0894734733016716 no 376 0.108468610873114 582 25236586
SGTC_1700 st030840 7.9285 µM 1.23447823752248 0.089511804142479 no 377 0.108512375591454 643 5499307
SGTC_1478 0453-0656 35.7 µM 1.23378938277773 0.0896242004738377 no 378 0.10864069836714 575 5258496
SGTC_1735 st034310 56.75 µM 1.23334334248343 0.0896970341684229 no 379 0.108723846835021 596 871153
SGTC_40 0327-0103 19.753 µM 1.22928154018017 0.0903623097852783 no 380 0.109483132994963 586 409036
SGTC_820 1582-0060 59.9 µM 1.22348288334183 0.0913184014134411 no 381 0.110573682627735 617 3848840
SGTC_2864 9034755 47.6 µM 1.22294936172764 0.0914067446416455 no 382 0.110674411473918 591 4930451
SGTC_695 3505-6186 243 µM 1.22145531494894 0.0916544736042675 no 383 0.11095683728799 619 1819379
SGTC_1237 0330-0133 46.1 µM 1.21802540922372 0.0922250699996119 no 384 0.111607158546635 559 X1237 YHR072W ERG7
SGTC_1298 1079-1278 263 µM 1.21794394676474 0.0922386539239294 no 385 0.111622637177474 641 2840950
SGTC_1242 0402-0103 60.1 µM 1.21485373307138 0.0927550435371499 no 386 0.112210941349015 567 432868
SGTC_1663 st014140 55.4 µM 1.21402487307931 0.0928939129753416 no 387 0.112369113076103 696 4207120
SGTC_1822 st052468 42 µM 1.21264667532936 0.0931251601394674 no 388 0.112632467725343 567 2873678
SGTC_2621 lithochol-11-enic acid 100 µM 1.20596861214876 0.0942516965447422 no 389 0.113914796576728 652 6708711
SGTC_1766 st045414 44.774 µM 1.2038048035995 0.0946188614272179 no 390 0.114332516317404 645 253960
SGTC_861 0443-0273 110 µM 1.20206249484333 0.0949152697244873 no 391 0.114669657986532 634 6149169
SGTC_3134 9127454 49.47 µM 1.19999593319013 0.0952677274190582 no 392 0.115070459941401 615 24262820
SGTC_2008 4012253 172 µM 1.19637428541147 0.095887731908277 no 393 0.11577526574962 634 603940
SGTC_552 k242-0005 476 µM 1.19229626573607 0.0965894109857779 no 394 0.116572549120847 612 4088318
SGTC_65 0798-0905 34.986 µM 1.18928026102192 0.09711077708444 no 395 0.117164700063621 733 3602145
SGTC_1319 1306-0155 43.7 µM 1.18374071265393 0.098073754663511 no 396 0.118257858764258 698 3122360
SGTC_865 0488-0499 301 µM 1.17785848874458 0.0991039413472781 no 397 0.11942651327122 686 9634651
SGTC_2187 6125751 200 µM 1.17674412859278 0.0992999939290018 no 398 0.119648824418597 646 874498
SGTC_311 1315-0136 58 µM 1.17397388392186 0.0997885993851968 no 399 0.120202743224415 659 6759207
SGTC_3186 9110464 49.47 µM 1.17096354309757 0.100321540741282 no 400 0.120806715773391 638 17018021
SGTC_1964 st076914 61 µM 1.17056322684918 0.100392567674891 no 401 0.120887192889589 645 24208661
SGTC_1352 1496-0991 99 µM 1.16796234924655 0.100854927594935 no 402 0.121410976186388 642 3000039
SGTC_597 k018-0003 82.8 µM 1.16678966635519 0.101063903389503 no 403 0.121647660581633 715 6786234
SGTC_2401 5128683 200 µM 1.16607388799069 0.101191612367611 no 404 0.121792286495063 592 708373
SGTC_2243 6634756 200 µM 1.1569746746902 0.102825351745553 no 405 0.123641353707549 607 885676
SGTC_2985 9022375 71.43 µM 1.15528805902315 0.103130272914564 no 406 0.123986242103332 659 4939335
SGTC_1570 verbenone 133 µM 1.15363395216375 0.103429954157388 no 407 0.124325136274149 704 29025 A natural terpanoid with antifungal properties.
SGTC_2385 9074692 200 µM 1.1458274437969 0.104852823486549 no 408 0.125933278694907 654 17046906
SGTC_512 prima-1 270 µM 1.14139058527431 0.10566780617993 no 409 0.126853710391378 694 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2897 9048598 12.99 µM 1.1411873968943 0.10570523812991 no 410 0.12689597392884 628 6467404
SGTC_994 3910-0338 138 µM 1.13850939854257 0.106199482772047 no 411 0.127453918310012 694 3479481
SGTC_1369 1866-0067 208 µM 1.1330523921612 0.107211776014731 no 412 0.128596126117939 737 3531355
SGTC_1167 k781-0610 148 µM 1.13281171931605 0.10725658129251 no 413 0.12864666446866 720 4525169
SGTC_517 1365-0151 113 µM 1.12538772009088 0.108645320404778 no 414 0.130212386219955 671 768657
SGTC_2118 5526350 200 µM 1.12496344998274 0.108725073561488 no 415 0.130302261391084 699 743594
SGTC_751 0833-0568 350 µM 1.12133038000954 0.109409732561388 no 416 0.1310736292714 690 6954252
SGTC_3149 9097855 49.47 µM 1.1162350376037 0.110375168580415 no 417 0.132160770182744 662 25236625 YMR079W SEC14
SGTC_3254 9136651 49.47 µM 1.11502074926157 0.110606143520493 no 418 0.132420765115402 725 16454030
SGTC_997 3996-0078 137 µM 1.11482526329238 0.11064336008819 no 419 0.132462654122003 704 735687
SGTC_1862 st057513 3.81 µM 1.11292583108413 0.111005440819631 no 420 0.1328701425026 675 5393163
SGTC_879 0831-1030 162 µM 1.11241416149216 0.111103123170063 no 421 0.132980059256617 732 1549252
SGTC_974 1326-0144 138 µM 1.11175068126932 0.111229879181801 no 422 0.133122681126457 723 5411856
SGTC_1093 fluphenazine 7.97 µM 1.10935948493966 0.111687569363297 no 423 0.133637566500962 722 6602611 An atypical antipsychotic.
SGTC_1523 st012844 44.7 µM 1.10858598426048 0.111835910306813 no 424 0.133804413589849 691 4274103
SGTC_2082 5219693 150 µM 1.10772583833757 0.11200103336898 no 425 0.133990118473126 697 2834649
SGTC_2016 5121758 140 µM 1.106623207998 0.112212961253471 no 426 0.134228434488359 752 2795203
SGTC_1460 k062-0059 9.15 µM 1.10218502945801 0.113068886746846 no 427 0.135190619498971 696 1373085
SGTC_1871 st057448 67.3 µM 1.0978343676955 0.113912446434487 no 428 0.136138410680911 745 691747
SGTC_1125 tnp00248 1.32998 µM 1.09732233623404 0.114012019547508 no 429 0.136250255058695 837 24207736
SGTC_2523 spermine 47.74 µM 1.0911728637596 0.11521273432353 no 430 0.137598413002163 696 1103 A DNA binding polyamine.
SGTC_1695 st026914 34.495 µM 1.08635537159033 0.116159633104689 no 431 0.138660899049641 724 3289191
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.08306746286217 0.116809048664913 no 432 0.139389239881106 813 551469
SGTC_972 1319-0219 195 µM 1.08150092332524 0.117119369373205 no 433 0.139737175095221 715 23903702
SGTC_374 0880-0231 82.3 µM 1.07956086719875 0.117504490154769 no 434 0.140168887729329 729 6833587
SGTC_274 sirtinol 40.1 µM 1.07954645290745 0.117507354889123 no 435 0.140172098668852 731 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1081 sertraline 6 µM 1.07719357061723 0.117975635914601 no 436 0.140696898504942 748 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_334 1502-1024 68.5 µM 1.07600225216436 0.118213240147718 no 437 0.140963124581898 741 3296216
SGTC_1276 0871-0068 94.2 µM 1.07579426348465 0.118254757421897 no 438 0.141009639198104 715 3414906
SGTC_1908 st060353 56.5 µM 1.07302520894692 0.118808479608832 no 439 0.141629902826201 788 4227716
SGTC_1575 cyproterone acetate 48 µM 1.06839915816402 0.119737622341931 no 440 0.142670248304656 695 9880 An androgen receptor antagonist and liver toxin.
SGTC_1659 st012954 42.1 µM 1.06712561518388 0.119994310676109 no 441 0.142957558158224 714 24207262
SGTC_1617 st002906 78 µM 1.06573567302457 0.120274902177783 no 442 0.143271573464793 751 5150859
SGTC_1399 3562-5772 25 µM 1.06555275673442 0.120311862389632 no 443 0.143312932515912 648 23847490
SGTC_3136 9095672 49.47 µM 1.06399656979661 0.120626630378349 no 444 0.143665126732825 651 17217380
SGTC_2859 9028643 45.46 µM 1.06238720400544 0.120952764180365 no 445 0.144029970216046 707 17151580
SGTC_3356 9151811 4.48 µM 1.05918369103582 0.121603793291983 no 446 0.144758065502175 730 1859254 YPR165W RHO1
SGTC_25 0118-0223 35.662 µM 1.05810997020175 0.121822548656696 no 447 0.145002654740891 750 5333628
SGTC_257 daunorubicin 18.5 µM 1.05714081089418 0.122020238360057 no 448 0.145223664031712 737 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_95 0471-0001 561.058 µM 1.05683153897098 0.122083371227883 no 449 0.145294238785152 713 4015405
SGTC_2485 5633444 17.78 µM 1.05596386171185 0.122260615962455 no 450 0.145492362814223 719 5724239
SGTC_365 0121-0052 13.6 µM 1.0552376341922 0.122409104865895 no 451 0.145658328051667 816 3101739
SGTC_2929 9013348 24.6 µM 1.05323955582298 0.122818297135032 no 452 0.146115606801126 705 2995952
SGTC_1201 1889-3372 45.9 µM 1.05315103173126 0.122836448405571 no 453 0.146135888643902 726 5392199
SGTC_92 0063-0024 660.874 µM 1.05267615991744 0.122933849793943 no 454 0.146244719277071 826 3594437
SGTC_2556 citropten 84.59 µM 1.05262199422586 0.122944963207705 no 455 0.146257136371899 801 2775 A potential DNA crosslinker.
SGTC_3199 9111318 49.47 µM 1.05138259993167 0.123199447675185 no 456 0.146541452038759 761 8548020
SGTC_2746 daunorubicin 9.88 µM 1.05000408306911 0.123482931512361 no 457 0.14685811775324 631 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_787 4152-0075 138 µM 1.04879246350777 0.123732470913839 no 458 0.147136823437267 727 9566539
SGTC_952 1185-0122 232 µM 1.04676487145459 0.124150853492786 no 459 0.147604017910929 734 678600
SGTC_252 miconazole 1.30953 nM 1.04654095869511 0.124197117283059 no 460 0.147655672384969 734 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_843 0310-0051 143 µM 1.04518190219919 0.124478177819405 no 461 0.147969453103443 756 2065037
SGTC_1901 st060216 58.6 µM 1.04321660707849 0.124885397947557 no 462 0.148423991841084 763 688792
SGTC_160 3453-0671 289.699 µM 1.04259591265459 0.125014202484449 no 463 0.148567741545663 814 5322268
SGTC_1638 st008370 60.6 µM 1.04189918224837 0.125158896275136 no 464 0.148729211653987 744 24207134
SGTC_1374 2889-5571 141 µM 1.03807373181191 0.125955432100025 no 465 0.149617864892603 797 2853281
SGTC_2617 dihydrotanshinone i 20.83 µM 1.03757609056803 0.126059310283799 no 466 0.14973372698417 785 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1912 st060209 90.8 µM 1.03392307726966 0.126823672844009 no 467 0.150586062778646 716 688787
SGTC_3335 9143315 29.6265 µM 1.03290699660501 0.127036851642361 no 468 0.150823712105312 752 4899691
SGTC_412 gemfibrozil 100 µM 1.03056623745465 0.127528903226694 no 469 0.151372137820028 724 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2173 5763948 167 µM 1.02979029404662 0.127692306562419 no 470 0.151554228977778 791 2867177
SGTC_2044 5102272 200 µM 1.02731303995325 0.128214957014826 no 471 0.152136542046042 713 592666
SGTC_1573 oleylamine 1.06 µM 1.02627526900204 0.128434346598147 no 472 0.152380925549574 756 5356789 An amine of the fatty acid oleic acid.
SGTC_1672 st016598 6.51 µM 1.02489246730622 0.128727082035793 no 473 0.152706964635621 759 4665860 YNL267W PIK1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.02335263658113 0.129053604489408 no 474 0.153070572409185 834 66535 A nucleotide analog.
SGTC_3208 9114115 49.47 µM 1.02212104169912 0.129315178294217 no 475 0.153361807673541 677 650895
SGTC_3148 9097893 49.47 µM 1.02189309064695 0.12936363223062 no 476 0.153415751495324 714 17174100
SGTC_78 0336-0123 156.75 µM 1.01982079166538 0.129804703238331 no 477 0.153906730278927 720 6765896
SGTC_2666 tannic acid 100 µM 1.01898472248269 0.129982947844835 no 478 0.154105109774673 816 16134267 A thiamine antagonist.
SGTC_1257 0669-0121 16 µM 1.01610105493293 0.130599026955877 no 479 0.154790633378644 862 4307855
SGTC_253 dyclonine 31.25 µM 1.01569853823746 0.130685182666056 no 480 0.154886482168507 848 3180 An oral anasthetic.
SGTC_263 alizarin 107.927 µM 1.0148241614101 0.130872471895983 no 481 0.155094827114207 854 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1006 4099-6547 255 µM 1.01440767523874 0.130961747334785 no 482 0.155194131724231 784 3146833
SGTC_3078 9116413 49.47 µM 1.01319531137966 0.131221861763122 no 483 0.155483439783644 725 17177322
SGTC_2204 7233102 200 µM 1.01283009082136 0.131300290252262 no 484 0.155570662564143 746 2172480
SGTC_2605 digitonin 300 nM 1.00879779856493 0.132168347795479 no 485 0.156535808537368 894 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2351 9026858 72.31 µM 1.00751852903262 0.132444569302884 no 486 0.15684282904407 740 1409300
SGTC_3009 9080819 71.4286 µM 1.00622678683184 0.132723887304959 no 487 0.157153244730292 799 17027216
SGTC_804 1595-0054 20.9 µM 1.00562458297916 0.132854242544706 no 488 0.157298096977612 750 761523 Stimulates phospholipase C.
SGTC_2034 5197015 53.07 µM 1.00492253013095 0.133006322724503 no 489 0.157467077370334 793 780676
SGTC_1240 0356-0016 42.1 µM 1.00027240875073 0.134016667388904 no 490 0.158589347966581 783 4305613
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.00017962167138 0.13403688101087 no 491 0.15861179464896 783 6710655
SGTC_872 0588-0139 234 µM 0.999391414209776 0.134208676117633 no 492 0.158802558686202 813 2047100
SGTC_2908 7930301 100 µM 0.999173629919186 0.134256170321113 no 493 0.158855293918016 875 2223178
SGTC_1063 disulfiram 1.84 µM 0.999115266417904 0.134268900142336 no 494 0.158869428259028 774 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_854 0422-0053 192 µM 0.997950813069207 0.134523055484202 no 495 0.159151605215171 789 3596728
SGTC_1191 1487-1166 10.6 µM 0.997785854648192 0.134559086245631 no 496 0.159191605409375 895 3955771
SGTC_1479 0549-0158 134 µM 0.997435532193685 0.134635626800204 no 497 0.15927657572333 853 5440202
SGTC_352 k048-0007 5.11 µM 0.997076858817612 0.134714022867049 no 498 0.159363602309961 853 6811911
SGTC_563 tetrahydrosecaminediol 614 µM 0.996558519057771 0.134827372920198 no 499 0.15948942449099 841 334274 A psychoactive constituent of the cannabis plant.
SGTC_1091 telmisartan 47.6 µM 0.996444713757508 0.13485226851456 no 500 0.159517058378472 826 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2826 7992541 19.48 µM 0.996427172359601 0.134856106081418 no 501 0.159521318010825 769 2985066
SGTC_2839 9003951 25.97 µM 0.995394185875851 0.135082226731636 no 502 0.159772292628851 786 2990634
SGTC_1899 st063254 59.6 µM 0.994969804270963 0.135175199135569 no 503 0.159875475300343 714 3093813
SGTC_1160 4092-0570 10.5 µM 0.992458870542842 0.135726185554876 no 504 0.160486866696812 810 4994975
SGTC_1405 3909-7894 12 µM 0.986607831701754 0.13701606981268 no 505 0.161917464692626 817 7104060
SGTC_583 1488-1091 88.9 µM 0.985644157256641 0.137229316351596 no 506 0.162153880642301 969 4303273
SGTC_3106 9121286 49.47 µM 0.984849728077179 0.137405281862975 no 507 0.162348944999398 769 15943471
SGTC_1219 1469-0211 33.1 µM 0.983638872684555 0.137673781750059 no 508 0.162646552458953 804 6822282
SGTC_1165 k072-0275 30.3 µM 0.9834939599957 0.137705939240131 no 509 0.162682193272684 799 6153523 YGL055W OLE1
SGTC_2298 7976326 193.81 µM 0.981861862474619 0.138068471019705 no 510 0.163083953239846 745 2235818
SGTC_1403 3909-7815 62.9 µM 0.981717606839072 0.138100545268306 no 511 0.163119494450893 787 6615483
SGTC_1530 rhein 70.4 µM 0.97988180678272 0.138509166574393 no 512 0.163572232224876 869 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1135 dihydrocapsaicin 536.708 nM 0.979313452981156 0.138635840374095 no 513 0.163712562650236 783 107982 A Capsaicinoid.
SGTC_3170 9103054 49.47 µM 0.978991354363155 0.138707664233365 no 514 0.163792125678631 764 16432970
SGTC_1970 st070122 35.8 µM 0.974321959481008 0.13975172663263 no 515 0.16494835231106 798 102928
SGTC_1258 0671-0043 57.1 µM 0.973288622929675 0.139983497634412 no 516 0.165204937648256 816 4298767
SGTC_1271 0832-2808 169 µM 0.972935794674359 0.140062694616542 no 517 0.165292606721163 878 3663794
SGTC_1397 3532-0190 20.1 µM 0.972166267027734 0.140235530893525 no 518 0.16548391967565 758 5322280
SGTC_1699 st031318 29.054 µM 0.969787767790514 0.140770658510735 no 519 0.16607614564339 846 5340658
SGTC_1100 amiodarone 5.07 µM 0.969501605043248 0.140835134207784 no 520 0.166147489893459 882 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2123 5259487 200 µM 0.966194771167668 0.141581654706496 no 521 0.166973364420689 874 2173474
SGTC_2197 6588183 93.1375 µM 0.963037686045943 0.142296866591258 no 522 0.167764305641257 813 884136
SGTC_2951 9072950 58.06 µM 0.962024595643336 0.142526891139393 no 523 0.168018624570883 943 16488155
SGTC_1445 4239-0156 97.7 µM 0.960289910674001 0.142921339080788 no 524 0.168454663238503 925 4008346
SGTC_10 0279-0212 42.575 µM 0.958042757226982 0.143433412509746 no 525 0.169020599229362 950 39851 YBR002C RER2
SGTC_737 1950-0117 57.9 µM 0.957104536189755 0.143647577130458 no 526 0.169257247130658 845 5393513
SGTC_2733 amorolfine 100 µM 0.953081003789694 0.144568461941574 no 527 0.170274515058124 803 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3347 9188721 44.724 µM 0.952843229547575 0.144623006638749 no 528 0.170334753741664 812 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.952640732183033 0.144669469855218 no 529 0.17038606600102 873 6728940
SGTC_730 1436-0052 41.2 µM 0.951555421721285 0.144918666738307 no 530 0.170661249309816 828 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2146 5545642 200 µM 0.948011778450551 0.145734329906095 no 531 0.171561729009957 856 825326
SGTC_2070 5230947 200 µM 0.947937210761307 0.145751526718777 no 532 0.171580710056651 911 2835538
SGTC_1024 4507-0395 26 µM 0.945725175664609 0.146262287054107 no 533 0.172144389101718 806 4201836
SGTC_3190 9110366 49.47 µM 0.94230346667854 0.147054726937712 no 534 0.173018646906396 776 17123768
SGTC_750 4073-0104 132 µM 0.942257027280961 0.147065501687084 no 535 0.173030531746173 733 22330957
SGTC_315 k915-0449 187 µM 0.939138785088124 0.147790199412864 no 536 0.173829746643229 953 20970215 YNL149C PGA2
SGTC_117 lucigenin 22.078 µM 0.938269671270871 0.147992611944952 no 537 0.174052920867397 893 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_769 0302-0231 76 µM 0.934961791192568 0.148764698152375 no 538 0.174903995394197 939 571869 YER009W NTF2
SGTC_2047 4141938 200 µM 0.934016413840651 0.148985850704337 no 539 0.17514771311721 815 3807862
SGTC_125 0133-0007 11.75 µM 0.933999520358879 0.14898980460063 no 540 0.175152070204925 985 26541
SGTC_2056 5235370 200 µM 0.932389591317781 0.149366927966249 no 541 0.175567611001626 815 5511916
SGTC_2399 5884133 200 µM 0.931186887624652 0.149649074934578 no 542 0.175878449716589 834 722445
SGTC_677 0929-0063 136 µM 0.93029312164008 0.149858977171252 no 543 0.176109669098 809 1539583
SGTC_152 4469-0003 551.229 µM 0.928678613272514 0.150238644309898 no 544 0.176527833740295 886 697280
SGTC_1521 st012942 49.4 µM 0.926239756152824 0.150813379584214 no 545 0.177160698011374 934 24207259
SGTC_128 0906-2981 13.371 µM 0.926002288609511 0.150869418716036 no 546 0.177222395445689 821 6740226
SGTC_2814 7977482 42.97 µM 0.922717182508347 0.151646081517342 no 547 0.178077304564978 926 6456762
SGTC_711 k292-0785 179 µM 0.92178520339345 0.151866902507944 no 548 0.178320313505628 920 4146315
SGTC_2638 epoxomicin 18 µM 0.920892750734595 0.152078558329305 no 549 0.178553211874987 928 9915668 A protesome inhibitor.
SGTC_1373 2887-0003 58.5 µM 0.918317263847861 0.152690463798636 no 550 0.179226395822427 848 776948
SGTC_768 0384-0033 77.3 µM 0.918281253225255 0.152699031061214 no 551 0.179235819624931 886 3965305 YMR134W ERG29
SGTC_3244 9134489 49.47 µM 0.917554652435487 0.152871964282265 no 552 0.179426034049463 878 16584271
SGTC_2400 5203494 178.7 µM 0.917157619346654 0.152966514225977 no 553 0.179530025631106 818 6777674
SGTC_665 3914-0008 307 µM 0.916280115210833 0.153175621638345 no 554 0.179759997361347 859 1069549
SGTC_177 1327-0068 8.361 µM 0.916108008054892 0.153216656626761 no 555 0.179805124010838 899 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_807 1315-0151 48 µM 0.91575853323487 0.153300003262777 no 556 0.179896778513431 971 4011080
SGTC_193 1273-0060 1.558 µM 0.915273991012105 0.153415611961676 no 557 0.180023904806598 782 2847393 YHR072W ERG7
SGTC_1430 4049-0248 69.1 µM 0.910875534129347 0.154467696868451 no 558 0.181180478986866 987 22774488
SGTC_2926 9010726 65.15 µM 0.906004852197449 0.155638287416008 no 559 0.182466642101045 881 2994293
SGTC_353 1988-1175 58.3 µM 0.904463310989894 0.15600998796736 no 560 0.182874890192445 855 2788357
SGTC_1439 4092-1168 46 µM 0.903169895778616 0.156322310734851 no 561 0.183217866262246 918 2886240
SGTC_57 miconazole 162.5 nM 0.90016799379507 0.157048770244971 no 562 0.184015428055103 868 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1966 st070145 16.1 µM 0.899741574698004 0.157152143386182 no 563 0.184128896504239 889 3748532
SGTC_2231 micatex 6.853 µM 0.898802678378649 0.157379909694151 no 564 0.184378886609488 927 20737 An antifungal of unknown mechanism.
SGTC_343 4130-2827 29.8 µM 0.89722031950881 0.157764263974218 no 565 0.184800682315882 905 1118244
SGTC_17 0960-0276 49.807 µM 0.897218828727576 0.15776462637479 no 566 0.184801079983118 968 6821114
SGTC_1838 st055369 84.5 µM 0.89689205411004 0.15784407665076 no 567 0.184888260242642 922 676036
SGTC_1949 st076024 69.1 µM 0.896723219602915 0.157885136485616 no 568 0.184933313644096 959 2921930
SGTC_648 0375-0473 33.3 µM 0.895968662129901 0.158068727369288 no 569 0.185134750283688 934 1713139
SGTC_573 3702-0553 84.7 µM 0.892903098400223 0.158816048299456 no 570 0.185954533858977 881 1222756
SGTC_2595 hexamethylquercetagetin 100 µM 0.892890646415909 0.158819088550208 no 571 0.185957868313308 860 386331
SGTC_2694 st077685 81.9 µM 0.892800628302765 0.158841068321377 no 572 0.185981974914416 889 2838096
SGTC_3077 9117319 49.47 µM 0.889712993164224 0.159596184828878 no 573 0.186810007727814 900 17154678
SGTC_346 4513-0042 7.16 µM 0.889275621767848 0.159703338667754 no 574 0.186927484909355 921 2827372
SGTC_2137 5261020 140 µM 0.889113782286396 0.159743000473472 no 575 0.186970966291346 904 763655
SGTC_605 1315-0399 119 µM 0.888928978394575 0.159788298019894 no 576 0.187020625168928 966 24020461
SGTC_235 0330-0087 5 mM 0.885903688011514 0.160531025916633 no 577 0.18783471431153 964 46494818 YHR062C RPP1
SGTC_288 1315-0019 35.1 µM 0.885045966552954 0.16074201164643 no 578 0.188065920067304 949 6811474
SGTC_1348 1493-0373 93.8 µM 0.88366926805827 0.161081035795507 no 579 0.188437387341242 924 3010129
SGTC_167 3672-0051 66.205 µM 0.882963655132222 0.161254979936158 no 580 0.1886279544292 874 3237971
SGTC_1495 4469-0029 237 µM 0.882522112470247 0.161363889110343 no 581 0.188747263649232 1000 793680
SGTC_1000 4048-0884 8.67 µM 0.88246641583254 0.161377630430163 no 582 0.188762316737707 889 13040088
SGTC_799 1310-0557 151 µM 0.879951009863381 0.161999019890275 no 583 0.189442924725731 925 5354492
SGTC_2857 9024691 58.44 µM 0.873517442820731 0.163595407214664 no 584 0.191190551520782 916 16478292
SGTC_1441 4106-0040 13 µM 0.872243296583167 0.163912774041174 no 585 0.191537832085285 968 2904180
SGTC_3274 9138298 49.47 µM 0.87132393318233 0.164142018834395 no 586 0.191788653100425 989 17015756
SGTC_3139 9095020 49.47 µM 0.871116965025121 0.164193655351614 no 587 0.19184514593918 775 25236292
SGTC_2160 5660466 132.927 µM 0.867764700854045 0.165031479202279 no 588 0.192761578920482 908 2859134
SGTC_3119 9125183 49.47 µM 0.864761325147838 0.165784452753349 no 589 0.193584901220101 823 22695334
SGTC_232 clozapine 119 µM 0.863677252350174 0.166056784301224 no 590 0.193882606588608 941 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_764 1951-2361 146 µM 0.863619276353079 0.16607135667597 no 591 0.193898535668873 895 5438930
SGTC_3056 9094900 49.47 µM 0.856887716504619 0.167768963185097 no 592 0.195753470991803 959 25236784
SGTC_1104 tacrolimus 29.8 µM 0.855303448228082 0.168170112434907 no 593 0.19619158954376 985 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2511 berberine 10.47 µM 0.854869673631599 0.168280055118753 no 594 0.196311650548638 928 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2017 5132927 60.65 µM 0.852201688225921 0.168957287865883 no 595 0.197051079901443 988 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3152 9099253 49.47 µM 0.851589564088287 0.16911291404563 no 596 0.197220966897135 1021 25236131
SGTC_1285 0929-0069 65.5 µM 0.85076526877366 0.169322627926345 no 597 0.197449879164708 960 1206237
SGTC_3058 9093861 49.47 µM 0.848874828842785 0.169804216127578 no 598 0.197975473251324 952 17217477
SGTC_3242 9133940 49.47 µM 0.846609838508231 0.170382376214172 no 599 0.198606314122192 1009 17248444
SGTC_3100 9120536 49.47 µM 0.84600618389529 0.170536677284147 no 600 0.1987746472701 873 16421196
SGTC_491 tetrandrine 80.3 µM 0.845965336817595 0.170547121498604 no 601 0.198786040858712 945 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1293 1000-1278 195 µM 0.84512720816717 0.170761513541418 no 602 0.199019909318229 990 678847
SGTC_453 enantio-paf c16 10 µM 0.843596610134157 0.171153483123347 no 603 0.199447429600529 1037 13871343 A lipid and platelet activating factor
SGTC_1978 st071761 42 µM 0.842746470016433 0.171371443147633 no 604 0.199685125830877 931 5147680
SGTC_2088 5278280 127.392 µM 0.841935441552888 0.171579540969117 no 605 0.199912045362022 997 791502
SGTC_1231 0242-0792 125 µM 0.841591142456537 0.171667931787703 no 606 0.200008424473403 973 3707635
SGTC_890 0929-0006 47.2 µM 0.840752568329673 0.171883337953695 no 607 0.200243282078459 951 1378169
SGTC_2476 5806916 10.51 µM 0.83782648634538 0.172636317429208 no 608 0.201064080463129 951 2870194
SGTC_410 α-linolenic acid 100 µM 0.836953609346838 0.172861344737634 no 609 0.201309322361067 1003 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1930 st074634 34.3 µM 0.836369600679833 0.173012006237861 no 610 0.201473504426208 1020 684253 YOR116C RPO31
SGTC_1163 k060-0048 49.9 µM 0.836320456649556 0.173024688140844 no 611 0.201487323922131 1035 6809982
SGTC_2920 7982904 15.77 µM 0.835239432595606 0.173303802467462 no 612 0.201791455814308 929 6456808
SGTC_817 1391-0715 46 µM 0.834098834545685 0.17359860908882 no 613 0.202112645920228 931 1353946
SGTC_2915 7971052 15.16 µM 0.830497993584414 0.174531398976592 no 614 0.2031286408861 858 5741558
SGTC_1026 k007-1105 30.6 µM 0.829105450489751 0.174892986140369 no 615 0.203522369908274 1002 7066794
SGTC_1 0258-0098 57.368 µM 0.82867053530616 0.175006013392579 no 616 0.203645431483754 886 6790032 YDR047W HEM12
SGTC_2426 5582046 32.21 µM 0.828287970862634 0.175105473858846 no 617 0.20375371680938 993 2251934
SGTC_1502 4534-4282 27.7 µM 0.826808970715017 0.175490326766976 no 618 0.20417267233276 967 3278949
SGTC_2486 5283202 22.39 µM 0.826495020114065 0.175572089266353 no 619 0.20426167090759 930 1377751
SGTC_2904 7225135 42.03 µM 0.81711621188301 0.178025748504316 no 620 0.206931009550432 1068 4446116
SGTC_2087 5276107 200 µM 0.81710828297499 0.178027831948964 no 621 0.206933274926044 1019 144405
SGTC_800 3448-7362 155 µM 0.816566821917747 0.178170145684745 no 622 0.207088010984475 1162 15991913
SGTC_2499 avocadenofuran 51.48 µM 0.816563105192076 0.178171122809964 no 623 0.207089073368413 1006 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1567 st069303 68.4 µM 0.814854415338414 0.178620694160992 no 624 0.207577824400847 1017 5581319
SGTC_2504 purpurogallin 52.29 µM 0.814472510892355 0.178721274175793 no 625 0.207687156892544 958 5281571 An antioxidant.
SGTC_180 1486-1293 102.781 µM 0.814057183312919 0.178830697119263 no 626 0.207806096444899 1026 4140536
SGTC_1524 corynanthine 62.1 µM 0.813209026519057 0.179054284975906 no 627 0.208049112511555 983 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3229 9132204 49.47 µM 0.812667890663542 0.179197029007743 no 628 0.20820424776829 1023 17682924
SGTC_1418 3966-3099 2.4 µM 0.811705676416641 0.179451024331802 no 629 0.208480268203539 1036 740335
SGTC_3031 9088762 49.47 µM 0.810748368978537 0.179703948881131 no 630 0.20875509509239 1058 205253
SGTC_183 3914-0051 30.55 µM 0.804852745155388 0.181266530032033 no 631 0.21045233007212 1036 1596232
SGTC_3213 9129884 49.47 µM 0.804465115374697 0.181369565014603 no 632 0.210564204177302 995 17190742
SGTC_283 0987-0079 11.7 µM 0.804233899228778 0.181431041504168 no 633 0.210630952246482 1078 411556
SGTC_296 1222-0039 74.9 µM 0.803883998943779 0.181524098917508 no 634 0.210731985962397 1007 5984176
SGTC_2711 st079103 59.1 µM 0.802081862557634 0.182003857506971 no 635 0.211252802969702 1023 54693780
SGTC_3089 9117425 49.47 µM 0.799768189178214 0.182620956884994 no 636 0.211922558446866 1010 9401657
SGTC_724 3910-0327 137 µM 0.798685486171933 0.182910181992793 no 637 0.212236402324441 1056 2885483
SGTC_1155 4088-0394 48.2 µM 0.796788204292818 0.183417696484073 no 638 0.212787023431201 1014 2326248
SGTC_2014 4013930 200 µM 0.794866016138075 0.183932767594869 no 639 0.213345722223982 1068 64556
SGTC_2507 purpurin 79.67 µM 0.793236505577021 0.184370117292136 no 640 0.213820021118872 1071 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1859 st055998 20 µM 0.792783675920649 0.184491768516871 no 641 0.213951934431176 1070 676301
SGTC_2151 5563267 85.4165 µM 0.79126767816568 0.184899399654569 no 642 0.214393902739935 1041 5310824
SGTC_1959 st077091 55.8 µM 0.789373414251035 0.185409527347931 no 643 0.214946894850219 1103 821356 YKL052C ASK1
SGTC_1721 st082152 9.2685 µM 0.788521218506609 0.185639309418012 no 644 0.215195946117703 1040 5296051
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.787301328463098 0.185968542200368 no 645 0.21555274610362 1037 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1386 3228-0095 33.8 µM 0.786511539885425 0.186181889023379 no 646 0.215783930553278 1034 870181
SGTC_2883 9059145 45.46 µM 0.784669496841742 0.186680072146155 no 647 0.216323685786963 1070 16476510
SGTC_2467 5474540 200 µM 0.783376767927288 0.187030184819499 no 648 0.216702947311108 1069 5413519
SGTC_13 0199-0087 65 µM 0.782574189227794 0.187247753250044 no 649 0.216938601652083 1097 4589825
SGTC_44 0929-0055 61.211 µM 0.78033601503573 0.187855318845511 no 650 0.217596559630607 1027 1379590
SGTC_747 3448-8087 38.7 µM 0.778287381552377 0.188412498293186 no 651 0.218199806366097 1075 5168703
SGTC_3287 9117173 37.0625 µM 0.776569475696102 0.188880512593626 no 652 0.218706408140398 1059 2789709
SGTC_1025 k007-0731 70 µM 0.776536137341326 0.188889602142374 no 653 0.218716246144599 1090 6256118
SGTC_2606 farnesol 9.78 µM 0.776449743141013 0.188913158376993 no 654 0.218741741884388 1074 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1404 3909-7820 48.3 µM 0.775616766552732 0.189140370538019 no 655 0.218987648827774 1063 23741373
SGTC_839 0122-0028 230 µM 0.774930915231413 0.189327577409103 no 656 0.219190241529127 1082 759448
SGTC_658 3253-0951 102 µM 0.768446171276501 0.191103256346066 no 657 0.221111079412583 1119 1184878
SGTC_3329 9141233 27.5565 µM 0.768137871811413 0.191187929677133 no 658 0.221202639619029 1078 4909101 YNL103W MET4
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.765972951892467 0.191783164718657 no 659 0.221846198185188 1078 364106
SGTC_1824 st053723 68.6 µM 0.764728657049074 0.192125790938039 no 660 0.22221656902398 1101 675225
SGTC_593 1203-0218 61.7 µM 0.763634171627284 0.192427475352066 no 661 0.222542639788334 1138 3666956
SGTC_1917 st066507 28.5 µM 0.763623832612662 0.192430326582611 no 662 0.222545721303482 1066 3156428
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.762494896889881 0.192741812989385 no 663 0.222882343854902 1116 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3069 9117009 49.47 µM 0.762182731143994 0.192827997465082 no 664 0.222975475638214 978 41904981
SGTC_1339 1486-1321 22.7 µM 0.760332158479588 0.193339397279094 no 665 0.223528031964737 1072 3469382
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.758733866326747 0.193781745580112 no 666 0.22400588687766 1070 4620898
SGTC_565 1418-0001 44.5 µM 0.755906032501602 0.194565895588528 no 667 0.224852768426124 1127 2862145
SGTC_2741 miltefosine 3.04 µM 0.755670236809899 0.194631368147462 no 668 0.224923466570812 991 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_838 0109-0203 71.4 µM 0.755547831621644 0.194665361250078 no 669 0.224960172038127 1127 759422
SGTC_2276 7947513 42.08 µM 0.754104334665854 0.195066506713443 no 670 0.225393287397648 1045 2105100
SGTC_3011 9081274 71.4286 µM 0.754007077984501 0.195093552244265 no 671 0.225422485833628 1120 6625322
SGTC_454 lyso-paf C-16 6.67 µM 0.753859463884017 0.195134605724513 no 672 0.225466806683463 1088 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3303 9125618 40.5795 µM 0.753319380767058 0.195284854896917 no 673 0.225629007633819 1138 22695467
SGTC_2244 6635614 200 µM 0.752910572066465 0.195398630727607 no 674 0.225751827367662 958 836499
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.750972216721035 0.195938643605514 no 675 0.226334688288923 1106 6708739 YPR165W RHO1
SGTC_803 4488-1585 147 µM 0.750643993614271 0.196030173935973 no 676 0.226433468633175 1089 747204
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.750252154894721 0.196139478468052 no 677 0.226551426279824 1125 23847180
SGTC_1995 st072814 61.1 µM 0.749981224257975 0.196215076953367 no 678 0.226633006495418 1063 5769371
SGTC_846 0335-0850 148 µM 0.747682971408644 0.196857074811505 no 679 0.227325702403131 1105 6819598
SGTC_1028 k015-0029 4.8 µM 0.747416704258204 0.196931536453763 no 680 0.227406032649345 1140 4588309
SGTC_415 dibenzyl ketone 100 µM 0.747204140873696 0.196990992068415 no 681 0.227470172460889 1101 7593
SGTC_2302 7771753 200 µM 0.746130003015148 0.197291602837229 no 682 0.227794443340313 1131 2203047
SGTC_2066 5222451 176 µM 0.745775217136913 0.197390954986069 no 683 0.227901606578646 1158 2281147
SGTC_1839 st053978 48 µM 0.745705174612883 0.197410572857962 no 684 0.227922766307453 1165 3788398
SGTC_139 0099-0334 718.624 µM 0.745044728263009 0.197595612051694 no 685 0.228122340377076 1185 97690
SGTC_3043 9092303 49.47 µM 0.744689040217386 0.197695309638482 no 686 0.228229863099562 1088 25236084
SGTC_2728 chlorpromazine 9.18 µM 0.743728936624409 0.197964573632573 no 687 0.228520239823621 1099 2726 A thorazine and dopamine antagonist.
SGTC_2756 carbadox 75.1 µM 0.743473674574322 0.198036199914281 no 688 0.228597476982946 1102 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_969 1313-0238 134 µM 0.743159366134695 0.198124416050946 no 689 0.228692600529412 1141 5212874
SGTC_2731 amoxapine 43.43 µM 0.741075329404385 0.198709937231107 no 690 0.229323883578488 1148 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.740829245294848 0.198779144678268 no 691 0.229398490232997 1150 94937 An inhibitor of serotonin biosynthesis.
SGTC_2178 5812956 200 µM 0.739858939402711 0.199052170170882 no 692 0.229692795671945 1133 5403383
SGTC_2263 7948595 193.29 µM 0.739703998651232 0.199095788441702 no 693 0.22973981063673 1048 2971371
SGTC_1132 3456-3614 2.5 µM 0.736862525971799 0.199896728652132 no 694 0.23060297745419 1196 3125502
SGTC_1001 4048-4355 44.4 µM 0.73636036292208 0.200038477092251 no 695 0.230755709968537 1131 21824233
SGTC_1572 epiandrosterone 68.9 µM 0.736275322980424 0.200062487785425 no 696 0.230781580396313 1110 441302 A steroid.
SGTC_3087 9117406 49.47 µM 0.733767006841524 0.200771479930509 no 697 0.231545376012915 1135 42546093
SGTC_2117 5521686 200 µM 0.733339401782166 0.200892495606382 no 698 0.231675724472473 1137 803312
SGTC_1353 1498-1206 8.11 µM 0.729909706070495 0.201864709522505 no 699 0.232722689510195 1186 6756808
SGTC_1870 st057514 26.5 µM 0.728360139741222 0.202304886515433 no 700 0.233196578424033 1151 5393161
SGTC_408 cantharidin 100 µM 0.72770281181284 0.202491783417895 no 701 0.233397764366512 1105 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2323 6148992 148.28 µM 0.727412649101635 0.202574317705735 no 702 0.233486604027081 1097 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1076 itraconazole 331 nM 0.727313643601502 0.202602483569298 no 703 0.233516921017607 1175 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3171 9103192 49.47 µM 0.726347688482617 0.202877408888121 no 704 0.233812825708503 1200 13018434
SGTC_250 brefeldin a 552.239 µM 0.726184927367707 0.202923755071487 no 705 0.233862705386458 1059 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_945 3381-0768 11.3 µM 0.726174259834626 0.202926792869436 no 706 0.23386597475841 1166 1126236 YIL048W NEO1
SGTC_1664 st014217 9.02 µM 0.724764002232936 0.203328631634106 no 707 0.234298411632742 1219 3982782
SGTC_452 diindolylmethane 8 µM 0.723477585370336 0.20369559701363 no 708 0.234693260066277 1081 3071 Inhibits expression of several cancer promoting factors.
SGTC_1154 4088-0362 150 µM 0.720763429303123 0.204471135901572 no 709 0.235527539709343 1192 6618304
SGTC_207 4185-0010 4.486 µM 0.720643241383277 0.20450551880195 no 710 0.235564520970691 1214 3761753
SGTC_825 1988-2224 89.6 µM 0.719771302846269 0.204755062655655 no 711 0.235832908282486 1139 1180859
SGTC_1097 itavastatin 7.23 µM 0.717185419856834 0.205496191923575 no 712 0.236629847223428 1201 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1789 tunicamycin 25 nM 0.715917472317871 0.205860174385513 no 713 0.237021154532442 1174 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2435 5706476 10.6 µM 0.715037124820013 0.206113115538288 no 714 0.23729305179455 1187 5725375
SGTC_1786 berberine 21.6 µM 0.713240020852236 0.206630030541548 no 715 0.237848622671197 1156 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2315 7733312 200 µM 0.713093778587298 0.206672129096087 no 716 0.237893864521419 1155 726316
SGTC_733 4069-0007 56.1 µM 0.713063721593894 0.206680782189565 no 717 0.237903163607964 1189 5717425 YNL287W SEC21
SGTC_1898 st060199 18.6 µM 0.711904749103863 0.207014601819892 no 718 0.238261880563753 1200 688866
SGTC_644 1498-1197 63.3 µM 0.711303257287491 0.207187975590365 no 719 0.2384481667749 1206 6741615
SGTC_482 fipronil 114 µM 0.702332533626095 0.209783869778428 no 720 0.241235904369193 1208 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_496 calpeptin 138 µM 0.700878900173743 0.210206306480089 no 721 0.241689296626679 1156 73364 A calpain inhibitor.
SGTC_1923 st058458 19.1 µM 0.700355843927423 0.210358432662842 no 722 0.241852552396959 1229 3534982
SGTC_2713 st079149 53.4 µM 0.700151781702861 0.210417799840145 no 723 0.241916260307197 1192 3103253
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.700009379066401 0.210459234414562 no 724 0.241960723582312 1208 688669
SGTC_924 2046-0044 21.3 µM 0.698112929370712 0.211011496542347 no 725 0.242553286452538 1211 3623589
SGTC_3222 9128301 49.47 µM 0.697178184067935 0.211284014511641 no 726 0.242845644977826 1222 4911358
SGTC_1423 4048-0112 5.59 µM 0.697111174218789 0.211303558646809 no 727 0.242866610844642 1199 X1423
SGTC_1681 tripelennamine 100 µM 0.695722890330412 0.211708704608276 no 728 0.243301193750804 1195 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3327 9140648 26.9345 µM 0.69401388370341 0.212208071578874 no 729 0.243836751072265 1181 8029710
SGTC_1940 st075990 51.1 µM 0.693072181527574 0.212483528308127 no 730 0.2441321271965 1297 1084979
SGTC_3140 9094243 49.47 µM 0.692268967776373 0.212718640847825 no 731 0.244384217169531 1245 19291112
SGTC_2973 9094665 17.96 µM 0.690864431663301 0.213130134158526 no 732 0.244825370071769 1223 25237061 YIL048W NEO1
SGTC_2261 9010538 184.68 µM 0.690168991157078 0.213334052259857 no 733 0.245043960602841 1141 6457250
SGTC_1547 harmine 94.2 µM 0.688838985984436 0.213724354986957 no 734 0.245462299416594 1252 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.68864272535283 0.213781984740394 no 735 0.245524063561205 1237 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_141 0443-0274 32.331 µM 0.688127057134956 0.213933448103482 no 736 0.245686386557053 1297 1627241
SGTC_957 1187-1561 14.1 µM 0.686377069677476 0.214447924340948 no 737 0.246237680202957 1191 1538454
SGTC_1837 st055472 66.5 µM 0.686133154619248 0.214519689650604 no 738 0.24631457271266 1265 676091
SGTC_466 geldanamycin 89.2 µM 0.685125553169532 0.214816296648125 no 739 0.246632348359967 1115 5288382 HSP90 inhibitor.
SGTC_2730 imipramine 71.33 µM 0.684926632789296 0.214874880862207 no 740 0.246695109477693 1236 3696 A tricyclic antidepressant.
SGTC_1611 st001856 99.4 µM 0.684536018677684 0.214989947965023 no 741 0.246818376524606 1181 647478
SGTC_1606 st000094 49.2 µM 0.684220988293827 0.215082775675439 no 742 0.246917815444717 1246 1242210
SGTC_3002 9075603 71.4286 µM 0.68378426081806 0.215211501465582 no 743 0.24705570334561 1207 20105405
SGTC_2870 9038528 12.99 µM 0.681883720926877 0.215772207650125 no 744 0.247656239913238 1211 6463316
SGTC_540 1187-0821 17.3 µM 0.681751992746035 0.215811102068703 no 745 0.247697892531699 1210 847520
SGTC_1683 st010134 710 nM 0.675631029585365 0.217622870612722 no 746 0.24963746777907 1244 3818134
SGTC_394 menadione 8.33 µM 0.675225116687692 0.217743327936701 no 747 0.249766375720967 1194 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2646 retinol 96.75 µM 0.67463339499098 0.217918994131515 no 748 0.249954355260776 1240 445354 A vitamin A analog and teratogen.
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.67348303220254 0.218260739554997 no 749 0.250320019977442 1208 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1359 1582-0056 520 nM 0.672957681908703 0.218416911284703 no 750 0.250487106855056 1261 3661189
SGTC_2418 pentamidine 31.67 µM 0.670340045447156 0.219196018938203 no 751 0.251320522330397 1221 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1936 st074407 74.3 µM 0.667166769919852 0.220142644668307 no 752 0.252332807195499 1270 809813
SGTC_154 3389-1638 511.116 µM 0.664851135701258 0.220834903128063 no 753 0.253072856098669 1163 5238686
SGTC_1790 st045711 43.5 µM 0.663646492728651 0.221195523248256 no 754 0.253458296547429 1260 585119
SGTC_1968 st069590 43.6 µM 0.663629914314345 0.221200488486485 no 755 0.253463603167655 1198 6384066
SGTC_387 norethindrone acetate 66.7 µM 0.663584525136312 0.221214082880162 no 756 0.25347813218583 1242 541197
SGTC_1179 1021-1431 9.29 µM 0.663317466046063 0.221294078725946 no 757 0.253563626322708 1242 2840958
SGTC_2601 securinine 100 µM 0.662176692139011 0.221635976493592 no 758 0.253928994944935 1226 442872 A GABA receptor antagonist.
SGTC_765 1319-0117 244 µM 0.66168222273408 0.2217842660935 no 759 0.254087450070885 1230 3487746 YGL099W LSG1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.658380009404593 0.22277603999805 no 760 0.255146988768889 1296 688751
SGTC_1036 k216-0215 33.5 µM 0.657787651651686 0.222954213381084 no 761 0.255337295103112 1252 622330
SGTC_2340 7987427 183.45 µM 0.657633071441844 0.223000722416279 no 762 0.255386969176042 1237 2239331
SGTC_1755 st041960 45.185 µM 0.657614002260445 0.223006460203866 no 763 0.255393097373176 1268 2257073
SGTC_21 0849-0113 22.993 µM 0.656244837256472 0.22341865237548 no 764 0.255833301981605 1230 1560156
SGTC_2656 pseudo-anisatin 100 µM 0.655336366515402 0.223692389899257 no 765 0.256125605723034 1275 6708809 A neurotoxin.
SGTC_2766 oltipraz 83.91 µM 0.653933269496177 0.224115541104452 no 766 0.256577399249866 1268 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1241 0364-0022 50.8 µM 0.653924237613172 0.224118266445126 no 767 0.256580308836244 1272 4563895
SGTC_914 3820-6779 408 µM 0.65389154452006 0.224128131634682 no 768 0.256590840934149 1242 2893481
SGTC_2576 guaiol 23.12 µM 0.653102579769406 0.224366277703409 no 769 0.256845074625999 1263 227829
SGTC_1177 0983-0204 23.6 µM 0.652880586256053 0.224433311501343 no 770 0.256916632791621 1284 766818
SGTC_304 1310-0298 97 µM 0.652761716351562 0.224469210470673 no 771 0.256954953996462 1203 1550234
SGTC_1977 st070720 65.3 µM 0.652752512616 0.224471990154713 no 772 0.256957921214964 1254 682188
SGTC_2807 7945238 51.95 µM 0.651245680496043 0.224927342289142 no 773 0.257443953374556 1290 17148797
SGTC_457 grayanotoxin iii 135 µM 0.650593643861873 0.225124544522783 no 774 0.257654417244887 1227 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1960 st011366 51.8 µM 0.650473000172891 0.225161042786467 no 775 0.25769336831115 1273 3972846
SGTC_1780 st038448 24.544 µM 0.649682003497687 0.225400425563636 no 776 0.257948825499933 1335 728868 YDL195W SEC31
SGTC_655 k060-0012 42 µM 0.649422146623629 0.225479098616082 no 777 0.25803277651805 1229 5994525
SGTC_2655 perillic acid 100 µM 0.648065385354705 0.22589011766784 no 778 0.258471330497363 1250 5702197 An apoptosis inducer.
SGTC_2928 9011484 9.79 µM 0.647391477844036 0.226094429477561 no 779 0.258689305038508 1263 2994751
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.64639122209522 0.226397874333697 no 780 0.259013011858093 1295 1273210
SGTC_38 0929-0051 58.268 µM 0.644340406241864 0.227020743382358 no 781 0.259677359664853 1278 1379719
SGTC_414 piperonyl butoxide 100 µM 0.643752182872992 0.227199575384101 no 782 0.259868072801824 1247 5794 A potent inhibitor of cytochrome P450.
SGTC_3112 9123419 49.47 µM 0.643066070895253 0.227408267816729 no 783 0.260090614535318 1311 17015854
SGTC_920 mycophenolic acid 780.421 nM 0.642320465464526 0.227635178563734 no 784 0.260332564435761 1277 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3210 9128157 49.47 µM 0.641277775049874 0.227952715112214 no 785 0.260671113143105 1276 17590849
SGTC_2365 9042475 200 µM 0.639139032786102 0.228604817770936 no 786 0.261366244730569 1297 6464479
SGTC_389 tpck 16.7 µM 0.635437550114444 0.229735871873051 no 787 0.262571542208366 1266 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1199 1638-0010 4.46 µM 0.635054490989977 0.229853101101669 no 788 0.262696438291807 1278 3111136
SGTC_2717 st081029 62.2815 µM 0.634658303535636 0.229974383272922 no 789 0.262825646821584 1267 5292846
SGTC_1080 nisoldipine 24.4 µM 0.633679408753585 0.230274199195419 no 790 0.263145032864085 1266 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.62735807903606 0.232215550937853 no 791 0.265212270219359 1307 6708561
SGTC_330 1488-0319 80.1 µM 0.627066119100914 0.232305434638758 no 792 0.265307947468625 1292 6846614
SGTC_2202 7226349 200 µM 0.624622556123472 0.233058476063018 no 793 0.266109406004717 1262 844334
SGTC_1817 st052116 64.4 µM 0.623539370881569 0.233392718184867 no 794 0.266465069195591 1325 4361398
SGTC_1833 st055984 71 µM 0.623412138798098 0.23343199606412 no 795 0.266506861545473 1311 676288
SGTC_2012 4023501 200 µM 0.623407492576597 0.233433430470847 no 796 0.266508387768199 1275 3477460
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.623207766645633 0.233495095567162 no 797 0.266573999291907 1266 6708514
SGTC_2881 9058953 51.95 µM 0.622456325627444 0.233727182835619 no 798 0.266820926674108 1267 17122249
SGTC_1294 1000-1494 117 µM 0.620645823986843 0.234286892473913 no 799 0.267416341142781 1285 712797 YDL207W GLE1
SGTC_1745 st081495 74 µM 0.620563517601343 0.234312354795552 no 800 0.267443424924297 1269 13842402 YBL026W LSM2
SGTC_3147 9097027 49.47 µM 0.617703498180059 0.235198081700977 no 801 0.268385402812234 1369 25236841
SGTC_1937 st074714 47.2 µM 0.61637449405858 0.235610292808435 no 802 0.2688236915973 1274 17250970
SGTC_2262 9014885 67.46 µM 0.616155310021366 0.235678314376519 no 803 0.268896010242341 1269 6457424
SGTC_729 4092-0585 94.1 µM 0.614702475960196 0.236129460570653 no 804 0.269375612199402 1285 2169061
SGTC_424 splitomicin 100 mM 0.614174414318533 0.236293556497842 no 805 0.26955003935021 1279 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1697 st025554 27.742 µM 0.612512290014306 0.236810473700036 no 806 0.270099434599061 1282 1269519
SGTC_2809 7964133 12.99 µM 0.611783035433085 0.237037466469298 no 807 0.270340657634381 1341 1253665
SGTC_2761 levamisole 97.89 µM 0.611295452105221 0.237189301667297 no 808 0.270502000635742 1388 26879 An alkaline phosphatase inhibitor.
SGTC_2269 7935389 174.42 µM 0.608980767620474 0.237910831069223 no 809 0.271268593416479 1307 97605
SGTC_2781 5567276 71.43 µM 0.608349705576384 0.238107753200802 no 810 0.271477780493203 1353 2853274
SGTC_623 k072-0108 16.9 µM 0.606502081130872 0.238684815397104 no 811 0.272090700405429 1325 5382803
SGTC_3038 9091290 49.47 µM 0.60468153740365 0.239254167260778 no 812 0.272695308908551 1367 25236843
SGTC_147 4466-0538 29.23 µM 0.604089526611557 0.239439470848018 no 813 0.272892061171028 1382 6742687 YHR072W ERG7
SGTC_853 0419-0306 21 µM 0.602649838499581 0.239890430331346 no 814 0.273370828963945 1282 762713
SGTC_2802 7925815 54.55 µM 0.602084352551534 0.24006768647619 no 815 0.273558994831097 1326 1262923
SGTC_1873 rapamycin 2 nM 0.601835478002907 0.240145720839201 no 816 0.273641828329038 1340 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2812 7970281 58.44 µM 0.600663887224593 0.24051325761376 no 817 0.274031938263938 1414 2233435
SGTC_2775 cyproheptadine 69.59 µM 0.599746466352727 0.240801273090455 no 818 0.274337607824261 1339 2913 A selective serotonin reuptake inhibitor.
SGTC_982 1491-0518 27.5 µM 0.597070153045793 0.24164254718287 no 819 0.275230272062694 1313 3091256
SGTC_653 0203-0016 55.2 µM 0.59668911301236 0.241762453184948 no 820 0.275357481298775 1376 295302
SGTC_1863 st057641 20.1 µM 0.594780396148669 0.242363575547846 no 821 0.275995136637622 1337 3921635
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.590919086604019 0.243582110646621 no 822 0.277287318353186 1373 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2567 aureobasidin a 60 nM 0.589995990467086 0.243873906538469 no 823 0.277596668803411 1425 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2796 7949634 45.45 µM 0.589188661354204 0.244129262371661 no 824 0.277867361252302 1327 2971588
SGTC_2352 9027995 87.8 µM 0.589068589509815 0.244167253057519 no 825 0.27790763160224 1362 2997347
SGTC_1868 st057644 42.7 µM 0.588585160815264 0.244320241961707 no 826 0.278069795370913 1340 688665
SGTC_500 h-89 112 µM 0.587706634578818 0.244598398144537 no 827 0.278364610777324 1454 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3050 9093513 49.47 µM 0.584611506316265 0.245579725263334 no 828 0.279404484540249 1352 25236664
SGTC_679 0422-0091 41.4 µM 0.583763177211106 0.2458490613605 no 829 0.279689827743616 1348 627384 YHR062C RPP1
SGTC_1053 3366-3204 134 µM 0.583360034030286 0.245977110885841 no 830 0.279825478168972 1309 3632071 YPR165W RHO1
SGTC_2265 7929201 200 µM 0.582617088548286 0.246213184816037 no 831 0.280075549521396 1333 1265108
SGTC_1248 0469-0687 58.6 µM 0.582610613424356 0.246215242846738 no 832 0.280077729488451 1408 4017482
SGTC_2134 5324836 1.464 µM 0.582260919596603 0.246326402007156 no 833 0.280195472425226 1391 699272
SGTC_3163 9099914 49.47 µM 0.580495251955145 0.246888075391305 no 834 0.280790343860156 1395 16268368
SGTC_26 0302-0163 425.158 µM 0.579777641771241 0.24711654884305 no 835 0.281032288467898 1372 3100915
SGTC_1723 st034307 2.5525 µM 0.579447569198491 0.247221675640162 no 836 0.28114360732004 1385 867466
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.579366350669405 0.247247547083247 no 837 0.281171001995435 1342 688803
SGTC_712 r015-0009 80.6 µM 0.579155397230267 0.247314751195374 no 838 0.281242161743832 1382 6813872 YLR060W FRS1
SGTC_2083 5306046 65.942 µM 0.577364388688417 0.247885711703989 no 839 0.281846662727501 1356 539837
SGTC_3245 9134821 49.47 µM 0.575833768644686 0.248374219256049 no 840 0.282363773102236 1318 17014901
SGTC_1164 k060-0068 93.7 µM 0.575093154120862 0.248610775388447 no 841 0.282614148813053 1391 5963676
SGTC_1483 3453-0561 55.9 µM 0.574619738173625 0.248762049758468 no 842 0.282774249974874 1391 4546991
SGTC_2409 alverine citrate 63.97 µM 0.574072781027317 0.248936884338527 no 843 0.282959275742844 1498 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_305 1682-2595 20.8 µM 0.574001740512694 0.248959597201252 no 844 0.282983311735984 1382 226033
SGTC_2603 homopterocarpin 100 µM 0.57390143920279 0.248991667116327 no 845 0.283017249555331 1380 101795 A weak amylase inhibitor.
SGTC_2798 7813637 45.45 µM 0.571095463167175 0.249889728237129 no 846 0.283967466886583 1419 956368
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.570409119625635 0.250109655977464 no 847 0.284200122814114 1414 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1709 st033179 39.1045 µM 0.570034330238597 0.250229794532341 no 848 0.284327206941648 1363 573381
SGTC_2984 9022109 38.96 µM 0.569985750526183 0.250245368975477 no 849 0.28434368140897 1405 6459207
SGTC_1891 st059073 26.2 µM 0.569071632045995 0.250538527170532 no 850 0.284653764460401 1441 688754
SGTC_1225 1216-0074 20.6 µM 0.569056844823093 0.25054327093446 no 851 0.284658781840494 1356 4241466
SGTC_507 nimesulide 162 µM 0.567265549919987 0.251118272982236 no 852 0.285266889446588 1433 4495 A COX2 inhibitor.
SGTC_1629 st005085 44.9 µM 0.565667442373646 0.25163185086566 no 853 0.285809935795579 1362 24207091
SGTC_2370 9071495 200 µM 0.565595844486156 0.251654872990676 no 854 0.285834276680847 1349 21791103
SGTC_2375 9072683 200 µM 0.565553724261282 0.251668417165354 no 855 0.285848596608002 1476 16798029
SGTC_603 3794-0023 45.9 µM 0.565079914393565 0.251820801932774 no 856 0.286009704781683 1421 3802260
SGTC_1253 0550-0034 176 µM 0.564707005628796 0.25194076955253 no 857 0.286136534190205 1389 5969915
SGTC_614 0462-0418 107 µM 0.564551430077325 0.251990828320138 no 858 0.286189454641361 1298 5188303
SGTC_99 0109-0120 622.8 µM 0.563848224770161 0.252217160637385 no 859 0.286428714353502 1451 759414
SGTC_756 0508-1999 28.3 µM 0.561205108695487 0.253068826724115 no 860 0.287328860354807 1339 6753853
SGTC_1667 st014849 34.6 µM 0.561065650813501 0.253113804888575 no 861 0.28737639161688 1419 5348460
SGTC_3282 9108498 15.4605 µM 0.56067648924111 0.253239340095955 no 862 0.287509048755481 1375 16459645
SGTC_2662 daunorubicin 22.37 µM 0.559819281045546 0.253515972577859 no 863 0.287801355405872 1356 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1065 prochlorperazine maleate 2.48 µM 0.558461267159884 0.253954546507679 no 864 0.288264723159945 1414 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3039 9090270 49.47 µM 0.5578609512086 0.254148546847609 no 865 0.288469668978945 1413 17173750
SGTC_910 3454-3003 490 µM 0.557856946482885 0.254149841290631 no 866 0.288471036409205 1349 820824
SGTC_1484 3473-2379 286 µM 0.556375093752091 0.25462905615101 no 867 0.288977230767454 1479 671917
SGTC_2232 chlorophetanol 41.5365 µM 0.555138428780295 0.255029341965937 no 868 0.289399989705559 1472 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.555138361738355 0.255029363675106 no 869 0.289400012631993 1431 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1730 st033808 45.1 µM 0.553925721676927 0.255422192516484 no 870 0.289814840501719 1454 1045166
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.553532846260069 0.255549530376541 no 871 0.289949297705182 1404 5106787 A p450 inhibitor.
SGTC_777 1315-0167 517 µM 0.552999034667199 0.255722601264911 no 872 0.290132035591789 1350 4221767
SGTC_1813 st051246 8.6015 µM 0.552294997960969 0.255950955607196 no 873 0.290373128551597 1405 5291959
SGTC_1059 3448-6867 171 µM 0.551288317538892 0.256277657192853 no 874 0.290718022821691 1395 3934407
SGTC_2023 5144124 124 µM 0.548574855060606 0.25715934829586 no 875 0.291648622918649 1393 2830192
SGTC_2968 9090663 33.37 µM 0.54714658889134 0.257624070627981 no 876 0.292139013530482 1419 25236811
SGTC_781 4335-2806 94.4 µM 0.546801168393182 0.257736527327949 no 877 0.292257670148794 1533 845254
SGTC_3059 1327-0034 3 µM 0.546696820846266 0.257770504210343 no 878 0.292293519352677 1364 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2964 9083345 53.42 µM 0.54624397172845 0.257917984549815 no 879 0.292449121982152 1376 17741579
SGTC_2200 6600604 21.907 µM 0.544903152816492 0.258354908471438 no 880 0.292910063876705 1367 2904777
SGTC_467 ro 31-8220 72.8 µM 0.544081256632679 0.258622923902316 no 881 0.293192778970972 1405 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2991 9074669 71.4286 µM 0.54289808248134 0.259009002546278 no 882 0.293599988139085 1497 17333109
SGTC_2380 9035439 200 µM 0.542814987727331 0.259036128188565 no 883 0.293628596426023 1502 6462575
SGTC_1749 st037932 54.2 µM 0.540868490111449 0.259671967359339 no 884 0.294299115441514 1418 594497
SGTC_3284 9108171 64.8615 µM 0.539511385383467 0.260115752750456 no 885 0.294767021553789 1443 8687505
SGTC_3305 9127027 53.8275 µM 0.539504655532602 0.260117954445756 no 886 0.29476934274382 1420 41905295
SGTC_2625 euphol 100 µM 0.539434366785647 0.260140950240277 no 887 0.294793586509625 1516 6708538 A triterpene alcohol.
SGTC_896 0964-0007 44.5 µM 0.53926198604518 0.2601973510735 no 888 0.294853047405005 1410 6756758
SGTC_2544 sphondin 68.51 µM 0.539129858198233 0.260240585927054 no 889 0.294898627236933 1464 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1743 st037606 46.3785 µM 0.537732727935753 0.260697981106215 no 890 0.295380790549643 1462 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_60 0986-0278 202 µM 0.537592038850547 0.260744063085404 no 891 0.295429363822243 1248 3110598
SGTC_293 4049-0273 38.5 µM 0.537520327756881 0.260767553294284 no 892 0.295454123677465 1373 1380311
SGTC_981 1488-1094 54.9 µM 0.536533254249354 0.261090996897331 no 893 0.295795029774177 1387 3449522
SGTC_298 1391-0729 10 µM 0.53573052683191 0.261354186058313 no 894 0.29607240132517 1410 3237558
SGTC_1350 1495-0454 146 µM 0.53481769541699 0.261653640370303 no 895 0.296387962786445 1485 1069057
SGTC_2345 9052315 157.45 µM 0.534699607530047 0.261692391955655 no 896 0.296428796465607 1448 6469265
SGTC_1794 st048918 76.9 µM 0.53420645863952 0.261854254951934 no 897 0.296599350570119 1397 672303
SGTC_2889 9059656 51.95 µM 0.533076632115708 0.262225283914352 no 898 0.296990267139802 1503 3949838
SGTC_1850 st056238 17 µM 0.531798905669322 0.26264520670609 no 899 0.297432640394341 1419 5393177
SGTC_2326 6164455 177.58 µM 0.529418121560921 0.26342856449464 no 900 0.2982577149638 1436 2888790
SGTC_1331 1472-0049 76.2 µM 0.527666116309623 0.264005793804561 no 901 0.298865547407334 1392 24051409
SGTC_2125 5246583 200 µM 0.524646552374058 0.265002153414542 no 902 0.299914459344677 1546 835267
SGTC_541 4513-1321 94 µM 0.524593660559863 0.265019623033885 no 903 0.299932847319789 1389 747515
SGTC_2456 5770359 74.46 µM 0.52329598055492 0.265448416520143 no 904 0.30038414883576 1524 3118787
SGTC_906 1165-0455 526 µM 0.521846124329332 0.265927909736628 no 905 0.300888736115068 1407 3252859
SGTC_2648 atorvastatin 78.68 µM 0.521639320943404 0.265996339035846 no 906 0.300960740156371 1503 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2824 7998404 51.95 µM 0.520603253580404 0.26633929823201 no 907 0.30132159117382 1473 837851
SGTC_47 0149-0135 24.25 µM 0.519366322704885 0.266749040141718 no 908 0.301752655712417 1345 5239155
SGTC_1534 6-azauridine 81.6 µM 0.517836363854954 0.267256289958737 no 909 0.302286222279594 1451 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3090 9117696 49.47 µM 0.517526389262065 0.267359119674855 no 910 0.302394376134491 1540 7923821
SGTC_2788 5282734 71.43 µM 0.515727559147565 0.267956250021834 no 911 0.303022351820337 1592 743706
SGTC_1987 st072290 61.9 µM 0.515599573901765 0.267998760919365 no 912 0.303067053988243 1480 54697379
SGTC_2225 6654152 15.4 µM 0.514988028339685 0.26820193550247 no 913 0.303280692858135 1495 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_161 4065-0411 162.148 µM 0.514766768952919 0.268275463887355 no 914 0.303358004751727 1514 1906281 YLR208W SEC13
SGTC_1750 st081859 2.357 µM 0.514561632754536 0.26834364331143 no 915 0.303429690788721 1481 5291695
SGTC_2770 toltrazuril 17.5 µM 0.514136025108543 0.268485126802048 no 916 0.303578445989258 1465 68591 Kills coccidiodes.
SGTC_3240 9133527 49.47 µM 0.513718417804465 0.2686239872058 no 917 0.303724436612313 1442 17617455
SGTC_2677 mitomycin C 100 µM 0.511519998562541 0.269355587646537 no 918 0.304493494271953 1466 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1661 st013063 9.66 µM 0.510923725491461 0.269554190338678 no 919 0.304702233611594 1483 721395
SGTC_430 0958-0115 16.4 µM 0.510888727667319 0.269565849461997 no 920 0.304714487395416 1471 6833180
SGTC_1075 aripiprazole 15.2 µM 0.509046506827053 0.270179920687999 no 921 0.305359812984067 1451 60795 An atypical antipschotic. YIL048W NEO1
SGTC_627 1391-0720 175 µM 0.5084274906662 0.270386415530592 no 922 0.305576788858224 1452 997839
SGTC_2412 st077135 33.4 µM 0.50719956486904 0.270796267123056 no 923 0.30600740015166 1543 13258915
SGTC_1014 4130-3005 69.3 µM 0.5070701570876 0.27083947833143 no 924 0.306052796746454 1447 743608
SGTC_1972 st070201 17.4 µM 0.506891874741745 0.270899015129524 no 925 0.306115343547723 1547 2829099
SGTC_3198 9112019 49.47 µM 0.506471796918453 0.271039324544524 no 926 0.30626274181252 1512 45595555
SGTC_702 1488-0190 94 µM 0.500628055543806 0.272994933287265 no 927 0.308316456875004 1564 949357
SGTC_1928 4'-methoxychalcone 40.3 µM 0.498303078677139 0.273774927696709 no 928 0.309135219117528 1641 641818
SGTC_398 bronopol 33.3 µM 0.497834610503346 0.273932224960388 no 929 0.309300309540231 1509 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_837 0091-0265 12.5 µM 0.495364019305278 0.2747625121155 no 930 0.310171594064858 1442 759367
SGTC_3161 9100388 49.47 µM 0.493963018156173 0.275233894712464 no 931 0.310666148770522 1562 25236368
SGTC_2312 7706453 155.7 µM 0.491452987523158 0.276079417056615 no 932 0.311553047599848 1482 976098
SGTC_1727 st034309 9.9045 µM 0.491408494025269 0.276094416515317 no 933 0.311568778901195 1615 870305
SGTC_261 5-fluorouridine 15.376 µM 0.489776023608734 0.276645024453779 no 934 0.312146199383358 1556 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_543 3844-1095 191 µM 0.486762133027105 0.277662976550044 no 935 0.313213454059674 1574 4230703
SGTC_1632 st005650 90 µM 0.486573811356236 0.277726643539305 no 936 0.313280193102011 1511 2759605
SGTC_2022 5136654 200 µM 0.486276501526634 0.27782717129224 no 937 0.313385568747289 1515 1713771
SGTC_2697 mebhydrolin 72.4 µM 0.484635037585794 0.278382510136217 no 938 0.313967627561743 1626 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1472 k841-0093 193 µM 0.484554877727509 0.278409643607341 no 939 0.313996063910128 1557 X1472
SGTC_1845 st056753 3.01 µM 0.484553588941484 0.278410079861632 no 940 0.313996521110183 1430 5375839
SGTC_1434 4073-0095 163 µM 0.484480850055983 0.278434702526869 no 941 0.314022325873934 1512 24133745
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.482345047703001 0.279158160454248 no 942 0.314780425603241 1504 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1131 3454-3128 32.3 µM 0.480438930723453 0.279804588037595 no 943 0.315457658809401 1602 710982
SGTC_1322 1348-1070 12 µM 0.480369950784162 0.279827995034429 no 944 0.315482178659085 1483 6758089
SGTC_3095 9117207 49.47 µM 0.479766756790124 0.280032717607642 no 945 0.315696626705845 1545 17015229
SGTC_3101 9120531 49.47 µM 0.479197603598434 0.280225953364424 no 946 0.315899029451622 1566 24824904
SGTC_1641 st009299 47.1 µM 0.478934522749428 0.280315294950199 no 947 0.315992605149689 1492 4046054
SGTC_2289 7946404 165.07 µM 0.47838198525319 0.280502980174705 no 948 0.316189176582796 1496 1246120 YPR165W RHO1
SGTC_1610 st001799 48.1 µM 0.476602400854411 0.281107880182878 no 949 0.31682263673699 1464 621897
SGTC_1915 st067105 30.6 µM 0.476234783497079 0.281232915786652 no 950 0.316953560701658 1458 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3045 9092950 49.47 µM 0.474564553207602 0.281801339650527 no 951 0.317548688249259 1631 44120432
SGTC_98 0074-0023 107.663 µM 0.473658746246228 0.282109841289977 no 952 0.317871637996078 1463 3563821
SGTC_1456 k015-0012 13 µM 0.473336193921732 0.282219736086236 no 953 0.317986671900494 1689 2989616
SGTC_2479 5617353 43.85 µM 0.47296764336137 0.282345327870104 no 954 0.318118131950264 1594 2731746
SGTC_1324 1418-0026 34.4 µM 0.472591377243155 0.282473576633427 no 955 0.318252367740707 1540 1372513
SGTC_546 peri-Naphthalide 147 µM 0.472146237767718 0.282625336762946 no 956 0.318411205448658 1606 223824 A penicillin ester.
SGTC_1210 3013-0140 750 nM 0.47191795718676 0.282703179007984 no 957 0.318492675037306 1651 905973
SGTC_1268 0828-0275 2.46 µM 0.471905925511088 0.282707282019644 no 958 0.318496969188194 1572 745337
SGTC_1381 2324-0066 62.1 µM 0.470494634798694 0.283188755231049 no 959 0.319000833250343 1548 10885928
SGTC_2407 paclitaxel 400 µM 0.469679446800049 0.283467042315972 no 960 0.31929202712815 1662 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2708 st078559 56 µM 0.469635310205403 0.283482113309272 no 961 0.319307796375751 1481 17250902
SGTC_3251 9135047 49.47 µM 0.467869858520924 0.284085263591541 no 962 0.319938829730512 1612 17682963
SGTC_2512 diallyl trisulfide 49.23 µM 0.467470380362254 0.284221826731996 no 963 0.320081689409593 1500 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_145 3737-0113 38.366 µM 0.467370063568338 0.284256125342521 no 964 0.320117568466504 1603 6849351
SGTC_630 4356-0227 183 µM 0.466305637784859 0.284620177513605 no 965 0.32049837193174 1534 779312
SGTC_2320 7373003 200 µM 0.465578295874757 0.284869069088914 no 966 0.320758690764877 1458 5415828
SGTC_1222 0366-0074 1.18 µM 0.465275578423387 0.284972687583868 no 967 0.320867060647369 1648 286520
SGTC_2744 captopril 92.04 µM 0.464882908746849 0.285107122997635 no 968 0.321007655286632 1628 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_822 1487-0950 154 µM 0.464366279358718 0.285284043621028 no 969 0.321192672565132 1556 1958375
SGTC_2028 5153890 36.43 µM 0.462141168934984 0.286046633657865 no 970 0.321990044405743 1522 2830968 YPR165W RHO1
SGTC_3035 9091303 49.47 µM 0.461036785526312 0.286425487389838 no 971 0.322386106772974 1540 25237002
SGTC_2363 9053361 176 µM 0.460301764774758 0.286677764845976 no 972 0.322649817320497 1643 6469797 YMR079W SEC14
SGTC_2815 7968870 71.43 µM 0.45970828869846 0.286881537488827 no 973 0.322862809627271 1496 2977326 YHR190W ERG9
SGTC_3221 9128209 49.47 µM 0.459284406166841 0.287027121439791 no 974 0.32301497218118 1561 16460723
SGTC_476 mead acid 10 µM 0.459161012725897 0.287069507926959 no 975 0.323059272712697 1561 5312531 An omega 9 fatty acid.
SGTC_998 3996-0085 177 µM 0.457906640772988 0.287500561365098 no 976 0.323509757843384 1676 715391
SGTC_1493 4348-0038 111 µM 0.456759608618469 0.287894996157343 no 977 0.323921920380983 1590 800424
SGTC_231 b-estradiol 524 µM 0.456568905442766 0.287960598830248 no 978 0.323990466617904 1493 450 A steroid.
SGTC_1831 st055328 12 µM 0.455910827582067 0.288187034488733 no 979 0.324227051558018 1632 1103068
SGTC_2840 9008771 71.43 µM 0.455594232285492 0.288296000550325 no 980 0.324340895726541 1682 2992978
SGTC_272 doxorubicin 8.13 µM 0.45496475773047 0.28851271138453 no 981 0.324567296593615 1537 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1919 st067113 52.3 µM 0.454616661599435 0.288632584293257 no 982 0.32469252293716 1528 1268243
SGTC_2045 5106652 78.05 µM 0.453479222567718 0.28902444453261 no 983 0.325101850698688 1611 673349
SGTC_1525 8-methoxypsoralen 92.5 µM 0.453128595765595 0.289145289759688 no 984 0.325228072622995 1727 4114 Related to psoralen; DNA damaging agent.
SGTC_1835 st008666 49.2 µM 0.451099608230953 0.289845056248853 no 985 0.325958880019765 1493 690455
SGTC_318 1488-0629 67.2 µM 0.447803402324902 0.290983557264991 no 986 0.327147543867582 1519 3662576
SGTC_1236 0330-0013 258 µM 0.44489794972773 0.291988822375172 no 987 0.328196752188474 1549 4617066
SGTC_395 anisomycin 6.25 µM 0.444469394471748 0.292137236061833 no 988 0.32835162579746 1539 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2863 9028737 58.44 µM 0.44395054734934 0.292316965840149 no 989 0.328539169047671 1654 6460917
SGTC_638 3970-0837 4.09 µM 0.443320474918331 0.292535293425115 no 990 0.328766974048336 1535 4118451 YLR208W SEC13
SGTC_2153 5569715 200 µM 0.442600452909866 0.292784882346228 no 991 0.329027378561539 1584 2054701
SGTC_3318 9139014 38.6185 µM 0.442276111608139 0.292897344528365 no 992 0.32914470756785 1565 16643984
SGTC_2557 derrustone 83.84 µM 0.441171032197221 0.293280670480597 no 993 0.329544591384006 1512 629853 An antioxidant.
SGTC_2999 9069765 71.4286 µM 0.440761230533935 0.293422880079993 no 994 0.329692931718501 1622 2097066
SGTC_2183 6420625 130.508 µM 0.438513216002549 0.294203554993692 no 995 0.330507145960571 1544 2897619
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.437949066486327 0.294399619449745 no 996 0.330711602923999 1543 688667
SGTC_276 colchicine 750 µM 0.437591403432318 0.294523952862366 no 997 0.330841252005365 1605 2833 A microtubule depolymerizer.
SGTC_1316 1272-0050 65.9 µM 0.436092892383135 0.295045139341694 no 998 0.331384666907349 1570 7340392
SGTC_1073 triclabendazole 3.09 µM 0.436078566371443 0.29505012401953 no 999 0.331389863758891 1597 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2061 5245884 80.95 µM 0.435632585023779 0.29520532082241 no 1000 0.33155166255248 1565 573863
SGTC_1867 st057372 64 µM 0.435368650237833 0.295297185040686 no 1001 0.331647430985373 1563 688837
SGTC_2640 pentamidine 10.38 µM 0.435317299237366 0.295315059618974 no 1002 0.331666064915763 1685 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1658 st012944 20 µM 0.435184756926641 0.295361198078662 no 1003 0.331714162966841 1618 24207260
SGTC_378 3970-0959 8.33 µM 0.434127038230155 0.295729512581765 no 1004 0.332098096040121 1595 6615653
SGTC_2266 7929956 200 µM 0.434011644660083 0.295769707226255 no 1005 0.332139992528073 1558 2967153
SGTC_2551 apiole 73.87 µM 0.433431490570653 0.295971828321346 no 1006 0.33235066359572 1567 10659 A possible DNA adduct former.
SGTC_1117 retinoic acid 1.10837 µM 0.432893048145675 0.296159474121238 no 1007 0.332546235332986 1691 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2176 5809774 33.9695 µM 0.43243659726968 0.296318588811701 no 1008 0.332712062008504 1670 2870539
SGTC_463 ikarugamyin 104 µM 0.431398035658368 0.296680768073525 no 1009 0.333089488986754 1619 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2624 nerol 100 µM 0.429094625625923 0.297484762470375 no 1010 0.333927181631521 1668 637566 A natural product oil.
SGTC_3268 9137683 49.47 µM 0.428618871909093 0.297650945943705 no 1011 0.334100304700391 1585 1953228
SGTC_198 3454-2873 16.191 µM 0.428268991762522 0.297773188092452 no 1012 0.33422764589028 1601 710957
SGTC_2882 9058044 58.44 µM 0.427168170987244 0.298157945360041 no 1013 0.334628421291227 1502 18076804
SGTC_3343 9148379 18.9835 µM 0.426972089314115 0.298226503294044 no 1014 0.334699828461588 1718 1955036
SGTC_2192 5915882 198.485 µM 0.425929070956257 0.298591304497949 no 1015 0.335079765456808 1568 2876149
SGTC_3283 9109332 35.8195 µM 0.425674536323454 0.298680360133196 no 1016 0.335172509621494 1540 17027281
SGTC_759 3486-0358 89.3 µM 0.421788231268834 0.300041583185367 no 1017 0.336589798287799 1751 875103
SGTC_1477 0139-0234 16 µM 0.420752460740245 0.300404846853579 no 1018 0.336967924478824 1631 620880
SGTC_409 arachidonic acid 100 µM 0.419140230476297 0.300970680487962 no 1019 0.337556825231175 1600 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_798 1287-0182 476 µM 0.419131429620925 0.300973770583424 no 1020 0.337560041020893 1724 1649755
SGTC_2919 7978188 46.38 µM 0.418072833023987 0.301345561981855 no 1021 0.337946933530249 1728 2980291
SGTC_760 0568-0725 82.9 µM 0.417566418373211 0.30152349376944 no 1022 0.33813207692652 1723 3916171
SGTC_2029 5175081 200 µM 0.417031055385239 0.301711648111333 no 1023 0.338327846307353 1581 1380876
SGTC_1670 st016595 4.04 µM 0.416373308411591 0.301942886781819 no 1024 0.338568428410506 1599 597879
SGTC_2158 5657123 3.6195 µM 0.415932648947054 0.302097850313594 no 1025 0.338729643945631 1613 2858827
SGTC_72 0744-0168 198.391 µM 0.415734188939724 0.302167652971639 no 1026 0.338802260313902 1659 677577
SGTC_1501 4491-0275 38.4 µM 0.415496628095447 0.302251217754314 no 1027 0.338889191527537 1686 5104718
SGTC_372 0155-0182 15.9 µM 0.415425024704631 0.302276407111374 no 1028 0.338915395212494 1680 771486
SGTC_2322 7413319 38.22 µM 0.414792224507635 0.302499060826863 no 1029 0.339147006063193 1630 1840400
SGTC_1313 1220-0047 237 µM 0.414502735305476 0.302600943465629 no 1030 0.339252982120665 1675 3528706
SGTC_3150 9097574 49.47 µM 0.414021691325869 0.302770275764835 no 1031 0.339429110572311 1729 17217476
SGTC_1337 1486-1011 40.3 µM 0.413564723773503 0.302931172214163 no 1032 0.339596456222875 1583 X1337
SGTC_2295 7971645 200 µM 0.412816351747553 0.303194753638301 no 1033 0.339870585128002 1666 2978226 YKL099C UTP11
SGTC_229 benomyl 22.8748 µM 0.408876139099011 0.304584209772023 no 1034 0.341315280239755 1592 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3350 9150499 3.57 µM 0.406206580917005 0.305527195442361 no 1035 0.342295409539928 1591 4910996 YPR165W RHO1
SGTC_1180 1193-0155 285 µM 0.404579998316602 0.306102397647657 no 1036 0.342893131707821 1582 2921347
SGTC_1678 st019265 80.2 µM 0.404557434258669 0.306110380256734 no 1037 0.342901426118095 1772 5367020
SGTC_1207 2099-0101 141 µM 0.404396345675846 0.306167372112524 no 1038 0.342960643499652 1728 5837381
SGTC_1473 k844-0725 134 µM 0.40393426043033 0.306330880212911 no 1039 0.343130530931381 1670 54682906
SGTC_1328 1441-0025 69.2 µM 0.403751884697976 0.306395424182982 no 1040 0.343197590806211 1528 4562601
SGTC_312 4092-0653 6.84 µM 0.40366458145029 0.306426323502308 no 1041 0.343229694110474 1684 1148278
SGTC_2138 5575593 77.673 µM 0.401513330051729 0.307188152298482 no 1042 0.344021112977884 1590 762213
SGTC_349 k015-0014 24 µM 0.400947659271712 0.307388613346524 no 1043 0.344229329966183 1583 2196908
SGTC_984 1492-0255 2.91 µM 0.39944340164393 0.307921968430025 no 1044 0.344783259753612 1661 1585198
SGTC_2614 arthonioic acid 13.39 µM 0.399107233264768 0.308041217066682 no 1045 0.34490709638847 1542 6710684
SGTC_736 0958-0254 92.6 µM 0.398074545981675 0.308407667814914 no 1046 0.345287618305841 1674 6812352
SGTC_45 0kpi-0036 14.9 µM 0.396861827427889 0.308838246760557 no 1047 0.345734677402243 1658 2795021
SGTC_103 0844-0104 51.839 µM 0.396129140306715 0.30909851670091 no 1048 0.346004881036957 1721 5375804
SGTC_960 1222-0186 7.7 µM 0.395123401003407 0.309455938110872 no 1049 0.346375909779759 1696 3126296
SGTC_1310 1188-0297 994 nM 0.393529042333117 0.310022913545131 no 1050 0.346964389013648 1642 1588352
SGTC_1934 st074720 32.6 µM 0.393501824833786 0.310032596382715 no 1051 0.346974438227349 1564 17250992
SGTC_927 2425-1185 123 µM 0.393423810250571 0.310060351408927 no 1052 0.347003243278118 1580 730375
SGTC_1421 4029-0249 71.4 µM 0.393345823785916 0.310088097513183 no 1053 0.347032038830413 1753 2894095
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.390237235270373 0.311194953589087 no 1054 0.348180565075266 1523 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3109 9122853 49.47 µM 0.388848056288522 0.311690143350395 no 1055 0.348694274535524 1694 1234709
SGTC_2337 9009472 200 µM 0.388653212471985 0.311759625066068 no 1056 0.348766348742045 1732 5742383
SGTC_1453 4237-0541 195 µM 0.386914000381222 0.312380128403582 no 1057 0.349409938026285 1777 739892
SGTC_2726 cimetidine 79.27 µM 0.384313408967276 0.313308941277903 no 1058 0.350373085391518 1673 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_66 0109-0187 42.4 µM 0.38368538796773 0.313533419716844 no 1059 0.350605821979056 1567 759417
SGTC_1066 ketoconazole 628 nM 0.381957333808376 0.314151447913771 no 1060 0.351246506106472 1731 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2191 5911152 200 µM 0.380654079103737 0.314617894222847 no 1061 0.351729973763387 1660 2875902
SGTC_2709 st078560 56 µM 0.376878699927871 0.315970804382215 no 1062 0.353131875629867 1778 17250903
SGTC_1051 3253-3903 78 µM 0.376235808288197 0.316201431578311 no 1063 0.353370798302995 1627 5509239
SGTC_1621 st003705 32.4 µM 0.375684417344176 0.316399291333443 no 1064 0.353575761928646 1759 24207032
SGTC_2296 7971656 126.45 µM 0.375031978473717 0.316633478773983 no 1065 0.353818342040232 1633 666570
SGTC_3266 9136860 49.47 µM 0.374334610865206 0.316883874297675 no 1066 0.354077692520036 1641 4871271 YPR165W RHO1
SGTC_2445 5742597 35.57 µM 0.373845110403312 0.317059683550201 no 1067 0.35425977781881 1613 1774255
SGTC_566 0958-0068 16.5 µM 0.373723690034266 0.317103299351072 no 1068 0.354304949154813 1705 6815365
SGTC_1518 st038567 90.8 µM 0.372431166737208 0.317567748188968 no 1069 0.354785926252066 1660 77966
SGTC_1011 4112-3381 17.4 µM 0.371814672310625 0.317789377447229 no 1070 0.355015419360785 1711 2877139
SGTC_151 3013-0144 2.285 µM 0.371584550518672 0.317872122789511 no 1071 0.355101096827881 1755 906558 YHR107C CDC12
SGTC_911 3456-4043 236 µM 0.370991494318245 0.318085411080493 no 1072 0.355321933463745 1741 914281
SGTC_2939 9044578 71.43 µM 0.36847830055275 0.318989931709667 no 1073 0.356258311174519 1628 2653634
SGTC_1791 st048313 56.1 µM 0.368187059257986 0.319094821887856 no 1074 0.356366879434283 1788 1204976
SGTC_2754 granisetron 64.02 µM 0.367106596044003 0.319484075826299 no 1075 0.356769753676739 1795 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_255 tunicamycin 200.472 nM 0.36600448415368 0.319881334071095 no 1076 0.357180864762414 1792 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2331 7980721 200 µM 0.363608845057271 0.320745558948232 no 1077 0.35807506043876 1777 2981221
SGTC_2998 9066762 71.4286 µM 0.362416900375658 0.321175914624398 no 1078 0.358520256014217 1785 4945196
SGTC_1647 st011722 22.4 µM 0.361709586647324 0.321431406280374 no 1079 0.358784531182883 1695 2854783
SGTC_426 0988-0037 14.6 µM 0.361452712715914 0.32152421367772 no 1080 0.358880524293625 1831 5383008
SGTC_2156 5649887 115 µM 0.361349983422453 0.321561332428984 no 1081 0.358918916455034 1778 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3231 9132313 49.47 µM 0.356670058052369 0.323254194898132 no 1082 0.360669411686987 1710 4905967
SGTC_314 1671-0008 2.74 µM 0.355761699450229 0.323583200073547 no 1083 0.361009517164525 1702 3913060
SGTC_2752 diclazuril 33.15 µM 0.355511193264345 0.323673957055533 no 1084 0.361103330445845 1787 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1148 3909-7663 27.7 µM 0.354989419874792 0.323863026286493 no 1085 0.361298758722488 1773 4084526
SGTC_2007 4011539 71.82 µM 0.354574411606332 0.324013440685356 no 1086 0.361454224371523 1635 45595301
SGTC_633 0437-0093 97.7 µM 0.353078121187102 0.324555990304604 no 1087 0.36201493734563 1672 2831118
SGTC_202 3594-0513 34.79 µM 0.35287063785647 0.32463125246397 no 1088 0.362092712109838 1710 708429
SGTC_3196 9111891 49.47 µM 0.352418725097899 0.324795203331436 no 1089 0.362262130523032 1684 18891510
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.352129534472661 0.324900137532713 no 1090 0.362370559894418 1640 4330530
SGTC_1088 bifonazole 369 nM 0.351315950844466 0.325195424749784 no 1091 0.36267566481539 1692 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1344 1488-0097 29.1 µM 0.350663111858444 0.32543244970303 no 1092 0.362920551391517 1731 747966
SGTC_1447 4239-0816 81.9 µM 0.349266946725819 0.325939589525133 no 1093 0.363444455254989 1642 1341554
SGTC_950 1165-0508 94.1 µM 0.347922469908616 0.326428258752037 no 1094 0.363949204871871 1654 6148369
SGTC_2488 5268135 45.7 µM 0.346510900606098 0.326941634449106 no 1095 0.364479396776651 1788 1270356 YLR208W SEC13
SGTC_610 4215-0184 155 µM 0.346469413707904 0.326956727841486 no 1096 0.364494983374355 1723 5605015
SGTC_489 paxilline 115 µM 0.345512318859204 0.327305008086042 no 1097 0.364854625373705 1680 105008 A toxic potassium channel blocker.
SGTC_2890 9046729 58.44 µM 0.344522740603998 0.327665266963395 no 1098 0.365226598544613 1647 903329
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.34276758026594 0.328304632854276 no 1099 0.365886658615844 1733 97141
SGTC_687 k029-0044 34.9 µM 0.341579518065589 0.328737703241095 no 1100 0.366333676633494 1845 5829338
SGTC_209 4077-0173 175.592 µM 0.33935634340038 0.329548708815057 no 1101 0.367170651097879 1733 15993494
SGTC_2068 5226020 147 µM 0.338976297956201 0.329687428337881 no 1102 0.367313792848224 1682 1810509
SGTC_1704 st028805 70.8 µM 0.338293015248084 0.329936890733661 no 1103 0.367571193397548 1708 2876101
SGTC_3130 9127414 49.47 µM 0.33816819398781 0.329982470398235 no 1104 0.367618221450335 1719 1494646
SGTC_2905 7799065 20.05 µM 0.337235299574659 0.330323205510635 no 1105 0.367969764516569 1826 1296806
SGTC_2096 5468907 200 µM 0.336937862596943 0.330431872511907 no 1106 0.368081871109903 1845 759785
SGTC_1379 2144-0755 36.5 µM 0.335590409891714 0.330924336124899 no 1107 0.368589878410659 1853 5392327
SGTC_1107 amlodipine 47 µM 0.333589481436902 0.331656170298059 no 1108 0.369344678311413 1696 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_351 caspofungin 25 nM 0.333575708062403 0.331661210103974 no 1109 0.36934987571992 1785 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1475 4092-1048 11.7 µM 0.333133740556557 0.331822946300011 no 1110 0.369516665653296 1713 2881759
SGTC_3291 9121177 71.43 µM 0.333088387167888 0.331839544960575 no 1111 0.369533782529214 1691 17015612
SGTC_16 erodoxin 22.806 µM 0.332104114146385 0.332199855404234 no 1112 0.369905321818607 1741 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1118 chelidonine 707.474 nM 0.331096199906171 0.332568980946159 no 1113 0.370285910974725 1875 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1481 3346-2004 36 µM 0.327786551600899 0.333782204569325 no 1114 0.371536528164719 1748 2770522
SGTC_1818 st052136 56.3 µM 0.327492035480008 0.333890250345305 no 1115 0.371647882959329 1680 674169
SGTC_2518 prenyletin 46.28 µM 0.327426613298944 0.33391425290575 no 1116 0.37167262015536 1839 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2707 st078556 66.6 µM 0.325729385219315 0.334537181382593 no 1117 0.372314554751058 1878 17250899
SGTC_359 0081-0058 15.9 µM 0.325495449954958 0.334623077711823 no 1118 0.37240306285967 1873 3494159
SGTC_2055 5235184 200 µM 0.323484579910535 0.33536178538137 no 1119 0.373164141884959 1752 2836034
SGTC_2101 5377231 179.231 µM 0.321887965186375 0.335948767229534 no 1120 0.373768785383512 1832 2844213
SGTC_3216 9129716 49.47 µM 0.321546910258557 0.336074205120157 no 1121 0.373897984396323 1683 8056934
SGTC_2583 asiatic acid 100 µM 0.317458092900841 0.337579464886506 no 1122 0.375448016574292 1771 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3026 9090633 49.47 µM 0.31593497190054 0.338140854182325 no 1123 0.376025933326747 1713 25236842
SGTC_797 k781-0471 270 µM 0.315007832904822 0.338482753859537 no 1124 0.376377853309293 1810 23738129
SGTC_2378 9074213 121.43 µM 0.314308111250473 0.338740877385022 no 1125 0.376643519141215 1729 657714
SGTC_2470 5664817 21.68 µM 0.313831156085647 0.338916866985358 no 1126 0.376824639917902 1767 2859561
SGTC_2663 amphotericin b 100 µM 0.31376980280181 0.338939508018631 no 1127 0.376847940417264 1774 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_664 1222-0054 14.9 µM 0.31339959744979 0.339076136223898 no 1128 0.37698854500896 1755 6813991
SGTC_1851 st056236 18.9 µM 0.312606462623338 0.339368922263232 no 1129 0.37728983379374 1885 5393171
SGTC_3336 9143619 71.43 µM 0.310997643951864 0.339963116098016 no 1130 0.377901206369391 1862 45595730
SGTC_2447 5741742 33.78 µM 0.310518716402576 0.340140077939326 no 1131 0.378083264396542 1817 1776504
SGTC_862 0452-0056 10.2 µM 0.309837980701963 0.340391667697039 no 1132 0.37834208373189 1816 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1169 aniline yellow 25.8 µM 0.308928068093802 0.34072806877024 no 1133 0.378688122587297 1836 6051 A DNA damaging agent.
SGTC_2127 5253358 187.912 µM 0.308233320962616 0.340985006984854 no 1134 0.378952399737914 1728 20612
SGTC_130 0136-0219 337.655 µM 0.306246603238533 0.341720161212078 no 1135 0.379708445791531 1914 234244
SGTC_1317 1273-0028 910 nM 0.305733473921181 0.341910134520217 no 1136 0.37990379219273 1766 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_460 trequinsin 123 µM 0.305063090146874 0.342158387675276 no 1137 0.380159050943695 1797 5537 A vasodilator.
SGTC_1010 4112-3296 15.2 µM 0.30433715948935 0.342427287626299 no 1138 0.380435518882639 1927 704384
SGTC_2175 5807670 165.306 µM 0.304324771899442 0.342431876943259 no 1139 0.380440237179765 1878 241186
SGTC_900 1112-0045 141 µM 0.303674220931191 0.342672923782972 no 1140 0.380688049887768 1862 56211 YIL048W NEO1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.301547655409363 0.343461320808799 no 1141 0.381498458136878 1887 1241132 A phosphatase inhibitor.
SGTC_683 panaxydol 45 µM 0.30071723044151 0.343769375503412 no 1142 0.381815064310116 1868 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2011 4012611 177 µM 0.300523860067537 0.343841123136495 no 1143 0.3818887996722 1721 2049887
SGTC_1986 st071812 45 µM 0.300481077451623 0.343856997845263 no 1144 0.381905113979148 1780 11838594
SGTC_3185 9108267 49.47 µM 0.300467827581881 0.343861914333127 no 1145 0.381910166598236 1711 4910486
SGTC_743 1275-0778 158 µM 0.299155036747379 0.344349168412291 no 1146 0.382410877309719 1883 2849257 YMR203W TOM40
SGTC_923 1900-2434 73.3 µM 0.298501189762818 0.344591946049735 no 1147 0.382660334092644 1739 5910570
SGTC_2900 5328528 85.29 µM 0.298010120947955 0.344774325201956 no 1148 0.382847719502305 1732 795359
SGTC_2645 abamectin 100 µM 0.29720192878995 0.345074560040253 no 1149 0.383156174703703 1871 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1888 azatryptophan 97.5 µM 0.296725459457803 0.345251609079353 no 1150 0.38333805906374 1766 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_938 3126-1755 342 µM 0.296515314228662 0.345329706741188 no 1151 0.383418286736096 1915 1777771
SGTC_1612 st002233 45.4 µM 0.296331431414472 0.345398049731062 no 1152 0.383488492241523 1794 1035021
SGTC_903 1134-0042 114 µM 0.296256039587156 0.345426071767067 no 1153 0.383517277556367 1769 701009
SGTC_1674 st016616 23.6 µM 0.295391730985886 0.345747383089862 no 1154 0.383847324677397 1674 625830
SGTC_1190 1486-1332 13 µM 0.294965184585913 0.34590599495757 no 1155 0.384010237862526 1754 4150046
SGTC_671 0560-0003 407 µM 0.294884196743931 0.345936113454161 no 1156 0.384041172305558 1854 3238678
SGTC_1874 staurosporine 7.6 µM 0.294035205645081 0.346251902638467 no 1157 0.384365500803123 1863 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_926 2268-1401 59.4 µM 0.293604233589702 0.34641224714919 no 1158 0.384530170181655 1771 2931578
SGTC_29 0299-0004 12.984 µM 0.292172033052822 0.346945299475278 no 1159 0.385077546775424 1856 16871 A napthoquinone isolated from Swertia calycina.
SGTC_15 0266-0086 27.098 µM 0.290403309890541 0.347604020692555 no 1160 0.38575385591714 1899 1712902 YIL048W NEO1
SGTC_137 0438-0332 85.389 µM 0.289678842903416 0.347873965179378 no 1161 0.386030971788828 1836 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_382 3229-0966 23.2 µM 0.289308256724418 0.348012079552415 no 1162 0.386172747204163 1884 5722370
SGTC_1685 st024049 53.0905 µM 0.286635026004437 0.349008966697164 no 1163 0.387195896186391 1830 1941139
SGTC_69 0096-0274 206.684 µM 0.286170212445157 0.349182409159699 no 1164 0.38737387857514 1877 6741392
SGTC_812 4251-0442 148 µM 0.28467976677939 0.349738772571184 no 1165 0.387944746642865 1920 5723007
SGTC_3192 9110362 49.47 µM 0.283538951031311 0.350164842020035 no 1166 0.388381863779771 1827 16649480
SGTC_1590 st077108 57.8 µM 0.282050171045643 0.350721152125508 no 1167 0.388952520171045 1929 5489485
SGTC_2861 9024595 19.48 µM 0.281144744492495 0.351059638143975 no 1168 0.389299691719363 1923 16482810
SGTC_2643 anethole 100 µM 0.280988913052192 0.351117906333447 no 1169 0.389359451752597 1823 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_146 3448-8650 53.125 µM 0.28065300487958 0.351243520368597 no 1170 0.38948827858058 1837 2891488 YIL048W NEO1
SGTC_3097 9117246 49.47 µM 0.280646746747985 0.351245860773036 no 1171 0.389490678801934 1783 16423892
SGTC_763 3453-1109 128 µM 0.280492919653502 0.351303390517664 no 1172 0.389549678419313 1939 1560353
SGTC_1836 st055642 81 µM 0.280072574623014 0.351460612590227 no 1173 0.389710912645054 1741 8571
SGTC_1128 3448-9350 235 µM 0.279727963102108 0.351589526944158 no 1174 0.389843111483126 1763 619386
SGTC_1820 st053765 18.6 µM 0.279632997443628 0.351625055270595 no 1175 0.389879544164708 1762 3690829
SGTC_2140 5586273 200 µM 0.279284277465188 0.35175552867549 no 1176 0.390013335601181 1817 854421
SGTC_1234 0326-0494 15.5 µM 0.276974844539474 0.352620041948375 no 1177 0.390899710965 1905 1547813
SGTC_2451 5856223 45.7 µM 0.27673386907605 0.352710292683115 no 1178 0.390992231665985 1776 2179896
SGTC_976 1348-1067 47.6 µM 0.276632464871784 0.352748273318514 no 1179 0.391031166885673 1805 5310671 YGL099W LSG1
SGTC_1879 gemcitabine 100 µM 0.27558829981223 0.353139447460619 no 1180 0.391432148594424 1857 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2515 chrysin 20.77 µM 0.273302416527419 0.353996346251261 no 1181 0.392310378951315 1909 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_503 tyrphostin 8 294 µM 0.273276991940918 0.354005881220704 no 1182 0.39232015010471 1928 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_631 k072-0230 41.5 µM 0.273106189075588 0.354069939703643 no 1183 0.392385794662518 1878 5773147
SGTC_739 1486-1183 203 µM 0.271360530703377 0.354724873845764 no 1184 0.393056877714167 1965 4346692
SGTC_1967 st070177 51.4 µM 0.270168931545081 0.355172183543542 no 1185 0.393515146626495 1894 5729214
SGTC_2128 5255449 168.493 µM 0.26989602733364 0.35527465609625 no 1186 0.393620121765812 1810 736008
SGTC_2065 5221596 34.26 µM 0.269362433033897 0.355475045162237 no 1187 0.393825396101383 1861 788581
SGTC_1249 0481-0015 10.2 µM 0.269356421899436 0.355477302845887 no 1188 0.393827708759838 1779 4227577
SGTC_2084 5306078 60.6385 µM 0.267145528605248 0.356308021503435 no 1189 0.394678557103626 1884 679340
SGTC_1882 5615643 20 µM 0.267067567208418 0.356337327112123 no 1190 0.394708569253766 1922 2253075
SGTC_775 4577-0580 57.3 µM 0.267062229462168 0.35633933359647 no 1191 0.394710624104378 1890 2006902
SGTC_391 gliotoxin 8.33 µM 0.266509566593566 0.356547103726618 no 1192 0.394923396338889 1882 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1343 1487-0095 224 µM 0.264352809018382 0.357358329972377 no 1193 0.395754035667045 1961 4560101 YGL055W OLE1
SGTC_94 0334-0113 514.748 µM 0.263985781393573 0.357496445253773 no 1194 0.395895437521805 1741 6795178
SGTC_3064 1327-0027 10 µM 0.262541814414834 0.358040002015723 no 1195 0.396451876172655 1851 16000455 YPR107C YTH1
SGTC_1388 3346-4487 254 µM 0.261044745515745 0.358603852080886 no 1196 0.397029000622311 1898 3345614
SGTC_1444 4112-3581 28 µM 0.26063268058627 0.358759104742902 no 1197 0.397187892503092 1864 2877249
SGTC_618 k072-0232 33.2 µM 0.25912776690477 0.359326305365042 no 1198 0.397768330702504 1856 5872756 YGL099W LSG1
SGTC_1660 st012960 28.1 µM 0.258214188916374 0.35967078346473 no 1199 0.398120803991079 1847 24207266
SGTC_961 1252-1571 372 µM 0.257853679123741 0.35980675041409 no 1200 0.398259917446546 1959 6813498
SGTC_1389 3405-0187 19 µM 0.257702678562137 0.35986370583472 no 1201 0.398318189360516 1795 799890
SGTC_2716 st080858 38.6235 µM 0.257054837387376 0.360108098284065 no 1202 0.398568220408871 1947 5296050
SGTC_1106 tegaserod maleate 11.7 µM 0.256540379015266 0.360302213974861 no 1203 0.39876680270282 1874 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2791 5663188 71.43 µM 0.256414906025719 0.360349562971526 no 1204 0.398815239586756 1937 54690634
SGTC_1920 st075728 45.7 µM 0.255856940957232 0.360560144865465 no 1205 0.39903065213276 1995 3400306
SGTC_2246 7293507 91.5585 µM 0.254764791797387 0.360972455831166 no 1206 0.399452385102799 1996 887656
SGTC_1662 st014054 52 µM 0.254607569104224 0.361031824265438 no 1207 0.399513106258652 1941 2838777
SGTC_2879 9041815 71.43 µM 0.251288326195106 0.362285973979514 no 1208 0.400795600005759 1979 4942971
SGTC_1815 st051655 58.2 µM 0.251259129688708 0.36229701223297 no 1209 0.40080688576043 1984 5984156
SGTC_474 dl-dihydrosphingosine 5 µM 0.251105006308438 0.362355283188614 no 1210 0.400866462707341 1939 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1761 st044296 37 µM 0.249323460473532 0.363029081090903 no 1211 0.401555292685534 1839 1826700
SGTC_39 0986-0283 58.349 µM 0.249093789848065 0.363115975658938 no 1212 0.401644116537279 1982 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2489 cantharidin 73.42 µM 0.247113350407768 0.363865555522688 no 1213 0.402410250975598 1785 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2914 7968218 45.32 µM 0.246012880803639 0.364282299613446 no 1214 0.40283613071943 1962 2977111
SGTC_1489 4065-0444 182 µM 0.245193987334878 0.364592515970473 no 1215 0.403153115866384 1991 2877968
SGTC_3307 9126885 69.2785 µM 0.243818020394043 0.365113964665235 no 1216 0.403685881594106 1799 24824909
SGTC_1153 4055-0057 267 µM 0.243716904402348 0.365152294336093 no 1217 0.403725040131562 1821 882706
SGTC_2058 5236698 133 µM 0.243326597965292 0.365300259009942 no 1218 0.403876200634522 1854 766665
SGTC_220 paclitaxel 373.376 µM 0.24318873106762 0.365352528969187 no 1219 0.403929598086575 1947 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2072 5231554 129 µM 0.243037514719723 0.365409863028284 no 1220 0.403988167994588 2043 789545
SGTC_2005 4024620 188 µM 0.242964596670812 0.3654375111651 no 1221 0.404016411764606 1870 236743
SGTC_2107 5363541 170.161 µM 0.242546621142373 0.365596007288839 no 1222 0.404178318296244 1932 244052
SGTC_2827 7993847 71.43 µM 0.240932044211002 0.366208469437016 no 1223 0.404803892936279 1890 2985692
SGTC_3073 9114972 49.47 µM 0.239483710878245 0.366758160126274 no 1224 0.405365262934138 1997 41905075
SGTC_2524 avocatin b 10.57 µM 0.23848693234798 0.367136629623554 no 1225 0.405751724740898 1990 6710748
SGTC_898 1000-0849 28.3 µM 0.23733445723426 0.367574376934136 no 1226 0.406198666300345 2010 6751807
SGTC_495 decylubiquinone 155 µM 0.235538019083092 0.368257065290614 no 1227 0.406895586888888 1851 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_529 4076-0302 30.3 µM 0.232563412923753 0.36938839920081 no 1228 0.408050220295016 1865 5816522
SGTC_3288 9119690 36.221 µM 0.23197461007529 0.369612473494917 no 1229 0.408278867085094 1829 17595618 YKL019W RAM2
SGTC_333 3486-0131 40.1 µM 0.231918944904941 0.369633659675803 no 1230 0.408300484872272 1999 6744690
SGTC_451 chloral hydrate 100 µM 0.231673764841709 0.369726979993059 no 1231 0.408395704832105 1909 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_317 4495-0002 170 µM 0.23108157846249 0.369952409325944 no 1232 0.408625713053756 1864 15991618
SGTC_874 0599-0792 117 µM 0.230127009558107 0.370315881936464 no 1233 0.408996538734952 2040 765305
SGTC_2198 6589944 200 µM 0.228759184839496 0.370836912398037 no 1234 0.40952804569129 1947 5290268
SGTC_1176 0848-0131 83.3 µM 0.226516021856513 0.3716918883624 no 1235 0.410400049702227 2034 6769040
SGTC_282 k297-0036 65.7 µM 0.22640233041492 0.371735238467612 no 1236 0.41044425778821 1958 5061378
SGTC_882 0843-0131 351 µM 0.222688980535685 0.373152015491964 no 1237 0.411888789143204 2034 5425421
SGTC_975 1335-0046 28.5 µM 0.221651900907162 0.373548006350671 no 1238 0.412292438093173 1825 16486740
SGTC_1613 st002381 52.1 µM 0.221534333701185 0.373592905783923 no 1239 0.412338203104177 2057 551167
SGTC_513 4245-1575 41.7 µM 0.220772483804156 0.373883901172447 no 1240 0.412634794843906 1992 719745
SGTC_1092 toremifene 6.32 µM 0.220331895724528 0.374052220556738 no 1241 0.412806340629786 2037 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_609 0986-0026 86.3 µM 0.218833882782078 0.374624691077522 no 1242 0.413389725929226 1944 2848610
SGTC_2154 5570129 200 µM 0.21801003604484 0.374939644694751 no 1243 0.413710645931444 2001 673366
SGTC_42 0133-0086 60.653 µM 0.215148241349397 0.376034345371919 no 1244 0.414825871651364 1900 162923 Model of phenazepam hydroxylation.
SGTC_589 1227-0070 34.1 µM 0.214425616167421 0.376310923925048 no 1245 0.415107583687536 1958 2841384
SGTC_178 4092-0806 87.505 µM 0.213285481901798 0.376747429612724 no 1246 0.415552148399687 1999 2169044
SGTC_1221 2958-7315 257 µM 0.213235064190913 0.376766735910046 no 1247 0.415571809931256 1960 4562705
SGTC_323 4013-0906 34.3 µM 0.212236614096325 0.377149132726741 no 1248 0.415961221705642 2048 2910086
SGTC_1652 st011932 78 µM 0.210719413547463 0.37773043658012 no 1249 0.416553112454249 2012 1551076
SGTC_2393 9031399 185.94 µM 0.208763803882545 0.378480122071463 no 1250 0.41731631451182 2000 1526623 YDL150W RPC53
SGTC_1019 4262-0212 3.4 µM 0.208736520604328 0.378490584394505 no 1251 0.417326964376082 2063 4677213
SGTC_165 k038-0023 64.381 µM 0.208306038784899 0.378655673111419 no 1252 0.417495008399469 1928 46368543
SGTC_3321 9137793 26.8275 µM 0.206137362767567 0.379487691252121 no 1253 0.418341807089823 2036 4904192
SGTC_2388 9080168 200 µM 0.206019971529984 0.379532744667917 no 1254 0.418387655454215 1850 15943073
SGTC_31 0508-1974 57.237 µM 0.205113583267067 0.3798806611569 no 1255 0.418741692070825 2011 6810525
SGTC_2670 beta-carotene 100 µM 0.204958820829822 0.379940076335771 no 1256 0.418802149098241 2017 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.20487836228339 0.379970966468459 no 1257 0.418833580509536 1882 2374 Ca(2+)-ATPase inhibitor.
SGTC_905 2-aminofluorene 215 µM 0.20436656474611 0.380167476800848 no 1258 0.419033528121465 2001 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2674 ligustilide 100 µM 0.204198166356273 0.380232141994433 no 1259 0.419099322102694 1964 5319022 A signalling regulator.
SGTC_2171 5739187 198.077 µM 0.203710148455901 0.380419560384905 no 1260 0.419290005585316 1906 2262761
SGTC_1772 st048439 82.2 µM 0.203473748022984 0.380510357701428 no 1261 0.41938238126533 1917 2927068 YDL195W SEC31
SGTC_1844 rapamycin 4 nM 0.202175211333911 0.38100922044796 no 1262 0.419889875728231 1943 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2779 methotrexate 400 µM 0.202113732447431 0.381032843888213 no 1263 0.419913906233581 2053 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2820 7989630 71.43 µM 0.201123574193949 0.381413376087478 no 1264 0.420300974535916 2090 2984098
SGTC_1945 st075991 56.6 µM 0.200505119243416 0.381651115510491 no 1265 0.420542777356512 1894 1084980
SGTC_814 3342-0569 96 µM 0.200203201923144 0.381767191360522 no 1266 0.42066083154863 1993 4346283
SGTC_1433 4060-0023 7.6 µM 0.199937763520119 0.38186925122224 no 1267 0.420764627833104 2015 3840627
SGTC_537 1334-0398 209 µM 0.199294133592325 0.382116758090593 no 1268 0.421016333924134 2073 5846986
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.199083620109337 0.382197721178311 no 1269 0.421098667011785 2068 5024745
SGTC_1212 0520-0165 585 µM 0.198926059846796 0.382258321928215 no 1270 0.421160292034874 2080 5403258
SGTC_2774 tamoxifen 10.92 µM 0.198482036081934 0.382429117640522 no 1271 0.421333969146506 2022 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_264 promethazine 12.5 mM 0.197599984695191 0.382768470445728 no 1272 0.421679023389476 2091 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_639 0833-0042 114 µM 0.19680859662183 0.383073018859471 no 1273 0.421988661779905 1914 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_919 tnp00227 403.569 nM 0.195992496145367 0.383387153012159 no 1274 0.42230801965297 1934 1269246 A methoxyflavone. YNL221C POP1
SGTC_2349 9023730 187.07 µM 0.195872283097575 0.383433432014365 no 1275 0.422355065955758 2040 4126287
SGTC_2143 5623677 140.463 µM 0.195709635716398 0.383496049815845 no 1276 0.422418721025215 2048 5375313
SGTC_1384 3089-0840 101 µM 0.195096237349871 0.383732230122011 no 1277 0.422658804070764 2055 1069836
SGTC_916 4466-0038 42 nM 0.193714997030141 0.38426421507415 no 1278 0.423199524173727 2108 5722064 YGL116W CDC20
SGTC_2333 9017922 200 µM 0.191702684159416 0.385039647816619 no 1279 0.423987551665427 2058 3163164
SGTC_205 1486-1330 71.903 µM 0.190965340695646 0.385323894028824 no 1280 0.424276373759173 1977 4118834
SGTC_472 calcifediol 10 µM 0.1908479813662 0.385369141787121 no 1281 0.424322347905854 1981 5283731 A vitamin D metabolite.
SGTC_577 r071-0003 38.6 µM 0.189036285703923 0.386067836644127 no 1282 0.425032188793929 2007 4568517 YMR134W ERG29
SGTC_1486 3970-0793 4.53 µM 0.188264245046446 0.386365692742759 no 1283 0.425334756234088 2097 2844330
SGTC_2174 5790901 200 µM 0.18819830384402 0.38639113620579 no 1284 0.425360601034417 1960 786020
SGTC_1588 farnesol 29.9 µM 0.187956710884874 0.386484359205168 no 1285 0.425455293005418 1928 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2642 cholecalciferol 100 µM 0.187844358326846 0.386527714697801 no 1286 0.425499330874627 2050 9821465 A vitamin D precursor, similar to steriods.
SGTC_1406 3909-7906 11.9 µM 0.187839922567938 0.386529426432559 no 1287 0.425501069540103 2030 X1406
SGTC_2387 9077560 195.08 µM 0.187065682958786 0.386828235000949 no 1288 0.425804567098089 1937 5303272
SGTC_1275 0867-0008 21.1 µM 0.186659933750638 0.386984855888512 no 1289 0.425963636064695 1993 3422836
SGTC_1719 st032227 49.2 µM 0.186395328898067 0.387087004381805 no 1290 0.426067377621556 1915 3125804
SGTC_2275 7947463 200 µM 0.186215533637342 0.387156417303132 no 1291 0.42613787146449 2098 1225414
SGTC_672 1441-0018 53.7 µM 0.184796760513495 0.38770428445083 no 1292 0.426694224417464 1952 251141
SGTC_213 1246-0773 967 nM 0.184157180424915 0.387951335069518 no 1293 0.426945074987523 2018 6251622
SGTC_2067 5224629 34.075 µM 0.183751508844317 0.388108057357769 no 1294 0.427104199306519 1912 2835000
SGTC_582 0987-0078 156 µM 0.183473060055793 0.388215640468892 no 1295 0.42721342746454 2072 1625765
SGTC_3000 9075062 71.4286 µM 0.181695378806005 0.388902677720098 no 1296 0.42791089639345 1958 17057871
SGTC_971 1315-0384 26.7 µM 0.181534989727507 0.38896468192738 no 1297 0.427973835772895 1916 6769120
SGTC_2877 9040724 71.43 µM 0.180714407055409 0.389281952095776 no 1298 0.428295874891696 2127 6463895
SGTC_2529 gangaleoidin 93.61 µM 0.180522283317875 0.38935624551093 no 1299 0.428371281099464 2004 4565183
SGTC_369 0957-0393 4.5 µM 0.180502046363764 0.389364071288711 no 1300 0.428379224007745 1913 6997992
SGTC_1205 4161-2785 76 µM 0.179629329919218 0.389701599755723 no 1301 0.428721788626347 1882 3498106
SGTC_3057 9095946 49.47 µM 0.179547774654895 0.389733146012059 no 1302 0.428753804003479 2071 24540043
SGTC_1254 0550-0035 264 µM 0.178257902040979 0.390232175968769 no 1303 0.429260219276558 2032 15121435
SGTC_236 1509-0011 5.31 µM 0.177858896567898 0.39038658113435 no 1304 0.429416895937521 2048 3107280
SGTC_790 1575-0012 79.1 µM 0.17745664342601 0.390542260569092 no 1305 0.429574859109209 2106 378741 YLR208W SEC13
SGTC_2119 5528445 120.635 µM 0.177037630644127 0.390704444957087 no 1306 0.429739415713666 2072 791935
SGTC_1910 st062352 60.4 µM 0.176807687247291 0.390793455644778 no 1307 0.429829725319255 1996 2245730
SGTC_2872 9044037 25.97 µM 0.174952278332118 0.391511890187711 no 1308 0.430558565759937 2040 6465195
SGTC_532 1548-0774 215 µM 0.174162053242291 0.391817986509842 no 1309 0.430869053423036 2106 5932993
SGTC_779 1360-0071 233 µM 0.173820630128827 0.391950258622724 no 1310 0.431003215349742 2134 7566
SGTC_2348 9022543 33.42 µM 0.17351321328795 0.392069366913145 no 1311 0.4311240213527 2005 3162678 YDL140C RPO21
SGTC_604 1000-0114 314 µM 0.172485165164125 0.39246775634849 no 1312 0.431528061530218 2087 1572745
SGTC_2086 5274770 176.623 µM 0.172436336783765 0.392486681140299 no 1313 0.431547253689405 1984 689278
SGTC_1783 st039459 87.517 µM 0.171868539831975 0.392706765238282 no 1314 0.431770440045118 2107 729761
SGTC_3331 9141060 1.957 µM 0.170063593493152 0.393406609082365 no 1315 0.432480062289433 1953 4906567 YPR165W RHO1
SGTC_1712 st032288 53.4 µM 0.169951391191975 0.393450125424422 no 1316 0.432524182311522 2021 2883011
SGTC_1157 4092-0394 27.6 µM 0.169561463308328 0.393601364712183 no 1317 0.432677515713216 2082 3659885
SGTC_341 1486-1430 230 µM 0.169031913057963 0.393806784297318 no 1318 0.432885769784994 1995 2054753 YPL210C SRP72
SGTC_1360 1598-0022 39.8 µM 0.169015742814861 0.393813057414959 no 1319 0.432892129284289 2061 761525
SGTC_3007 9078383 71.4286 µM 0.166281894101062 0.394874027252214 no 1320 0.4339675570485 1990 6496995
SGTC_1957 st077035 62.4 µM 0.164579860262522 0.395534958164119 no 1321 0.434637342106795 2142 705593
SGTC_860 0443-0016 25.1 µM 0.164314171887235 0.39563815699456 no 1322 0.434741912885877 2148 5337942
SGTC_1855 st056195 39.6 µM 0.1636896182568 0.395880775277864 no 1323 0.434987745369591 2130 4028379
SGTC_2358 9037157 4 µM 0.163018742519713 0.396141433098692 no 1324 0.435251838836975 2036 2388925
SGTC_3330 9141424 71.43 µM 0.16261871811885 0.39629687816082 no 1325 0.435409324124008 2114 27261020
SGTC_1519 esterone 74 µM 0.161802243064418 0.396614202490372 no 1326 0.435730793305267 1901 698 A steroid.
SGTC_2461 5755302 26.15 µM 0.159975783135418 0.397324306715875 no 1327 0.43645007538382 2131 2788904
SGTC_2953 9074162 66.49 µM 0.159623413719231 0.397461342680865 no 1328 0.436588866995132 2154 16451992
SGTC_3029 9088683 49.47 µM 0.158910900221621 0.397738476821182 no 1329 0.436869536345809 2045 25236615
SGTC_1458 k015-0034 6.33 µM 0.158865135638177 0.397756278850896 no 1330 0.436887564763442 1943 3598957
SGTC_3237 9133362 49.47 µM 0.158785546989271 0.397787238658499 no 1331 0.436918918084709 2128 43845137
SGTC_68 0986-0284 82.829 µM 0.158779477726293 0.397789599614732 no 1332 0.43692130903931 1818 423278 YIL048W NEO1
SGTC_2785 7756463 72.73 µM 0.158221311766764 0.398006743354214 no 1333 0.437141205456219 2035 2201551
SGTC_260 nsc-65238 3.989 µM 0.157738733489676 0.398194506628644 no 1334 0.437331338822456 2090 3246252
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.157694309740452 0.398211792364877 no 1335 0.437348842279994 2114 140250 A respiratory chain inhibitor.
SGTC_580 1123-0028 41 µM 0.15760588941058 0.398246198216122 no 1336 0.437383681250719 2117 1677248 YPR107C YTH1
SGTC_955 1216-0110 33 µM 0.157572879809521 0.398259043015032 no 1337 0.437396687666015 2028 3619719
SGTC_169 k015-0017 16.025 µM 0.156396218485179 0.398716981045407 no 1338 0.437860358855293 2105 1840002
SGTC_2816 7982706 58.44 µM 0.156216772111761 0.398786831016619 no 1339 0.437931078402325 1997 2981853
SGTC_3184 9108758 49.47 µM 0.15612447661079 0.398822758544935 no 1340 0.437967452693229 2074 902885
SGTC_592 k241-0073 46.5 µM 0.155092130275439 0.399224674541242 no 1341 0.438374343124038 2137 4230158
SGTC_3248 9135562 49.47 µM 0.154862234584179 0.399314192743548 no 1342 0.438464963418705 2011 17650701
SGTC_1072 oxiconazole 14.9 nM 0.151284392227604 0.400708034619434 no 1343 0.439875690386198 2122 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_884 0851-0618 334 µM 0.15009237738291 0.401172696967715 no 1344 0.440345866914081 2138 9642473
SGTC_1827 berberine 7.24 µM 0.149654314174446 0.40134349467287 no 1345 0.440518677075754 1907 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_104 0074-0074 590.992 µM 0.149460348538704 0.401419126507753 no 1346 0.440595197583162 2150 3943124
SGTC_2688 kanamycin b 96.69 µM 0.148202851215099 0.401909544224798 no 1347 0.441091340861899 2054 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_362 0310-0100 9.03 µM 0.147210470465325 0.402296676902954 no 1348 0.441482948201003 2041 790235
SGTC_876 0720-0963 56.8 µM 0.147165317913817 0.40231429342108 no 1349 0.441500767393716 2169 765861
SGTC_3094 9117742 49.47 µM 0.146676318600172 0.402505091914863 no 1350 0.441693755715757 2166 17149698
SGTC_2130 NSC 7 2.4545 µM 0.146402938133748 0.402611770045048 no 1351 0.441801654003937 2127 21448
SGTC_1804 st050076 49.1 µM 0.145479889471188 0.402972014294277 no 1352 0.442165996350876 2091 3895976
SGTC_2526 patulin 37.61 µM 0.145340035585601 0.403026603180199 no 1353 0.442221203234046 2062 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2306 7482397 179.52 µM 0.144030507339711 0.403537840277606 no 1354 0.442738189710608 2132 891448
SGTC_2424 5537928 59.2 µM 0.143690666649948 0.40367054035488 no 1355 0.442872370823499 2033 5382802
SGTC_3261 9137475 49.47 µM 0.143006310427165 0.403937799565982 no 1356 0.443142598710435 2172 17027690
SGTC_990 3985-0011 41.3 µM 0.142845890260893 0.404000454378626 no 1357 0.443205946748916 2073 5399565 YGL099W LSG1
SGTC_3247 9135149 49.47 µM 0.140888359727956 0.404765199010272 no 1358 0.443979069006097 2156 8934436 YOR116C RPO31
SGTC_2091 4-phenylthiadiazole 200 µM 0.13841984061026 0.405730089036536 no 1359 0.444954308705506 2070 270010
SGTC_3238 9133470 49.47 µM 0.136524961185182 0.406471144977556 no 1360 0.445703146559735 2176 3534688
SGTC_2534 helenine 20.12 µM 0.136280258740494 0.406566868536536 no 1361 0.445799864759115 2077 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1803 st050068 52.4 µM 0.135840190732976 0.406739029926287 no 1362 0.445973808956659 2167 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2634 4'-methoxyflavone 100 µM 0.134749526581031 0.407165792190815 no 1363 0.446404956850379 2036 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2545 solidagenone 89.61 µM 0.13360392748002 0.407614168460729 no 1364 0.446857889178163 2165 6708572 An anti ulcer agent
SGTC_2703 st077852 53.4 µM 0.133342247360037 0.40771660450162 no 1365 0.446961358666772 2081 6281836
SGTC_2108 5365811 200 µM 0.132685950854075 0.407973542915667 no 1366 0.447220877104617 2126 780283
SGTC_2000 st075254 36.4 µM 0.130374335166352 0.408878849098082 no 1367 0.448135135417611 2163 17234175
SGTC_1012 4112-3522 18 µM 0.130057473097536 0.409002980914044 no 1368 0.44826047791091 2170 3112398
SGTC_2032 5185112 25.99 µM 0.126930436346431 0.41022849599847 no 1369 0.449497728373987 2156 5718189
SGTC_858 0438-0351 2.77 µM 0.126916447796502 0.410233980222376 no 1370 0.449503264227845 2068 2799119
SGTC_1312 1218-2183 165 µM 0.126892797673068 0.410243252315019 no 1371 0.449512623592498 2197 6744073
SGTC_3103 9120822 49.47 µM 0.126224074528665 0.410505447718802 no 1372 0.44977727752808 2170 17141819
SGTC_2575 plumbagin 510 nM 0.125304358355545 0.410866118702925 no 1373 0.450141300956009 2045 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_483 fpl-64176 144 µM 0.124101691304228 0.41133786387166 no 1374 0.450617379523141 2173 3423
SGTC_716 1683-5115 658 µM 0.123467390543493 0.411586719517172 no 1375 0.450868497629562 2205 723597
SGTC_2304 7443016 91.4 µM 0.121789925792703 0.412245011565501 no 1376 0.45153269630392 2148 939854
SGTC_1250 0485-0349 40.2 µM 0.121734458886898 0.41226678282237 no 1377 0.451554660968399 2101 6842794 YDL195W SEC31
SGTC_2436 5633522 8.09 µM 0.120778688998763 0.412641973408845 no 1378 0.451933165116533 2204 5724242
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.12013068421824 0.412896395229995 no 1379 0.452189812952587 2226 688664
SGTC_1145 3546-0597 10.2 µM 0.119671990280196 0.413076511315273 no 1380 0.452371494693275 2103 875334
SGTC_80 0159-0065 512.242 µM 0.118458673453069 0.413553034503733 no 1381 0.452852119144062 2200 1548079
SGTC_2995 9067767 71.4286 µM 0.117589823274279 0.41389434869385 no 1382 0.453196334424936 2102 11673567
SGTC_1446 4239-0190 62 µM 0.116357721086358 0.414378472230644 no 1383 0.453684520706784 2030 1340085
SGTC_2495 cafestol 54.53 µM 0.115358105083334 0.414771341810776 no 1384 0.454080642255741 2132 16667697 An anti-infammatory.
SGTC_819 1013-0258 27.7 µM 0.11514493058886 0.414855134800221 no 1385 0.454165123627876 2115 5753198
SGTC_3041 9091929 49.47 µM 0.113543652766501 0.415484676346976 no 1386 0.454799778461047 2159 25236887
SGTC_1779 st039427 55 µM 0.113353719689091 0.415559362865825 no 1387 0.454875064743711 2233 1124498
SGTC_89 0302-0250 142.109 µM 0.113118227434437 0.41565196864817 no 1388 0.45496841216968 2226 4203518 YLR208W SEC13
SGTC_530 4358-1714 28 µM 0.1130649253283 0.415672930001658 no 1389 0.454989541084215 2144 1564641
SGTC_3076 9116187 49.47 µM 0.112791681343683 0.415780388504349 no 1390 0.455097856791179 2190 27241210
SGTC_1193 1488-0126 41.5 µM 0.110365568015937 0.41673477998579 no 1391 0.456059729509136 2194 1384710
SGTC_2111 5486399 200 µM 0.109409445961706 0.417111037237792 no 1392 0.456438870966457 2195 689674
SGTC_268 camptothecin 39.6153 µM 0.109064042515199 0.417246980570517 no 1393 0.456575847315021 2221 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2190 6049624 200 µM 0.107679634219443 0.417791952894972 no 1394 0.457124912552584 2187 2265554
SGTC_2923 7992654 58.14 µM 0.106684387320652 0.418183829465088 no 1395 0.457519684511957 2120 2985126
SGTC_3179 9107801 49.47 µM 0.106643190005112 0.418200052583138 no 1396 0.457536026634544 2181 4818259
SGTC_3086 9117350 49.47 µM 0.105945188910822 0.418474940026607 no 1397 0.457812920116313 2224 2679265
SGTC_1792 st045773 43.6 µM 0.104799268206959 0.418926313876919 no 1398 0.458267545369607 2099 2919270
SGTC_1149 3909-7961 23.3 µM 0.104482997656788 0.419050910476702 no 1399 0.45839303016488 2059 735261
SGTC_1814 st052110 31.539 µM 0.104202433918339 0.419161446969237 no 1400 0.458504351250971 2214 674163
SGTC_2121 5257820 149.641 µM 0.103747270484682 0.419340785813116 no 1401 0.458684956304524 2241 791256
SGTC_2434 5670830 169.91 µM 0.101602135896696 0.420186214808268 no 1402 0.459536242012365 2138 1549830
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.100675023089439 0.420551717804329 no 1403 0.459904219651851 2228 3256 An antibiotic and ribosome inhibitor.
SGTC_2565 isoliquiritigenin 100 µM 0.100481343957569 0.420628082117712 no 1404 0.459981096618642 1974 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_836 0330-0104 1.35 µM 0.100170926280547 0.420750480638454 no 1405 0.460104313680669 2232 46494820
SGTC_2291 7917025 104.35 µM 0.100165642621948 0.420752564065527 no 1406 0.460106411007085 2148 2964612
SGTC_1754 st042065 16.137 µM 0.0989225937522214 0.421242778736794 no 1407 0.460599864834983 2149 1126236 YIL048W NEO1
SGTC_2444 5485484 36.41 µM 0.0987434558501486 0.421313434497582 no 1408 0.460670982331798 2190 6790631
SGTC_3001 9076041 71.4286 µM 0.0973878746472409 0.421848186250297 no 1409 0.461209186792798 2219 16004211
SGTC_294 k038-0071 157 µM 0.0963944953214662 0.422240147621432 no 1410 0.461603631931837 2146 24152826
SGTC_3319 9138450 16.7555 µM 0.0956736477048971 0.422524623392533 no 1411 0.46188988547674 2104 2029690
SGTC_1459 k035-0031 35.7 µM 0.094685650458588 0.42291459289607 no 1412 0.462282258020142 2189 3877128 YMR208W ERG12
SGTC_2212 7123476 200 µM 0.094144393897811 0.423128262745571 no 1413 0.462497227864021 2193 1085715
SGTC_418 lividomycin a 100 µM 0.0940595906736838 0.423161742251128 no 1414 0.46253090999425 2254 72394 An antibiotic.
SGTC_776 4476-4378 112 µM 0.0928704390947205 0.423631266308395 no 1415 0.463003245205509 2090 2892008
SGTC_1223 0764-0573 147 µM 0.0923723927611115 0.423827946952783 no 1416 0.463201086507708 2225 1609797
SGTC_478 N-arachidonylglycine 10 µM 0.0922754225199712 0.423866243127651 no 1417 0.463239607515658 2248 5283389
SGTC_1948 st076329 66.6 µM 0.0914688616935462 0.424184803674377 no 1418 0.463560023630402 2253 24208413
SGTC_3063 1327-0034 4 µM 0.0903916085744816 0.424610354515173 no 1419 0.463988012391833 2227 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_555 4296-0685 37 µM 0.0895435775975969 0.424945416831533 no 1420 0.464324961369612 2255 2908540 YHR072W ERG7
SGTC_1762 st045503 25.4615 µM 0.0884939731610376 0.425360197148219 no 1421 0.464742037134284 2160 4645554
SGTC_2248 tofa 1.1 µM 0.0881637777307495 0.425490700141176 no 1422 0.464873253178772 2125 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1202 1988-0068 29.6 µM 0.0864752290533296 0.426158191796857 no 1423 0.46554432332361 2122 2850480
SGTC_1897 st060201 15 µM 0.0863692838042848 0.426200079553171 no 1424 0.465586431818759 2074 611878
SGTC_2819 7996655 46.38 µM 0.0857332026393693 0.426451585552561 no 1425 0.46583925370019 2237 6456960
SGTC_2474 5321570 43.32 µM 0.0856280358338665 0.426493171310208 no 1426 0.465881055466529 2234 2841384
SGTC_1653 st012112 65 µM 0.0843672867503434 0.426991768590658 no 1427 0.466382207960452 2235 720429
SGTC_3081 9117243 49.47 µM 0.084231328397365 0.427045543976806 no 1428 0.466436255114582 2233 45595589
SGTC_1048 3161-0300 24.5 µM 0.0838317508523299 0.427203596077149 no 1429 0.466595101667771 2244 2165101
SGTC_2508 celastrol 40.54 µM 0.083424289551119 0.427364778615469 no 1430 0.466757087779074 2251 122724 Celastrol is a natural product and antioxidant.
SGTC_2477 5967686 25.23 µM 0.0826535307852346 0.42766970661079 no 1431 0.467063517720087 2212 776118
SGTC_951 1171-0579 82.7 µM 0.0780190419543183 0.429504110296443 no 1432 0.468906452935789 2260 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1561 5-methoxyflavone 52.9 µM 0.0775505381323845 0.42968963692398 no 1433 0.469092794336765 2273 94525
SGTC_1516 st013856 110 µM 0.0775419528751372 0.429693036814624 no 1434 0.469096209076286 2199 5281404 A mutagen and neurotoxin.
SGTC_1707 st032323 6.317 µM 0.0768854271327492 0.429953046283152 no 1435 0.469357345345806 2204 3132057 YMR211W DML1
SGTC_1903 st060211 78.3 µM 0.0764903056612139 0.430109544248767 no 1436 0.469514513171267 2257 688960
SGTC_1876 myriocin 605 nM 0.0763970299159136 0.430146490096515 no 1437 0.469551616242869 2276 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_300 r073-0011 5.04 µM 0.0762063308185851 0.430222026532087 no 1438 0.469627473036709 2288 2735780
SGTC_1027 k015-0025 8.67 µM 0.0751529583635504 0.43063931618947 no 1439 0.470046506120027 2284 3598955
SGTC_904 1141-0088 396 µM 0.0744170913790938 0.430930873197396 no 1440 0.470339254778258 2112 1378119
SGTC_1809 st050081 57.6 µM 0.0742745081063111 0.430987370310023 no 1441 0.470395980287977 2238 5036894
SGTC_690 glyoxal 20.3 µM 0.0740754065059957 0.43106626457439 no 1442 0.470475192125537 2208 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1137 ixabepilone 100 µM 0.0729057409543607 0.43152980149398 no 1443 0.470940562741407 2287 154225 A novel microtubule stabilizer.
SGTC_3309 9129340 25.759 µM 0.0720719396796221 0.431860293454648 no 1444 0.471272328514192 2222 17158987
SGTC_3205 9113483 49.47 µM 0.0706673063801926 0.432417152576466 no 1445 0.471831270745175 2256 17018033
SGTC_134 0269-0018 6.916 µM 0.0700828309352218 0.432648904265024 no 1446 0.472063866013469 2195 4378915
SGTC_2661 dactinomycin 12.96 µM 0.0693034314878296 0.432957981750442 no 1447 0.472374047187532 2298 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_611 3453-1652 23.7 µM 0.0692204121788292 0.432990906184598 no 1448 0.47240708775352 2276 1560575
SGTC_3159 9100096 49.47 µM 0.0675376738396267 0.433658359415032 no 1449 0.47307683554565 2280 25236875
SGTC_2962 9082311 13.18 µM 0.0673002256740757 0.433752557812574 no 1450 0.473171348617974 2223 16459453
SGTC_1323 1348-1351 11.2 µM 0.0667279300357055 0.43397960947795 no 1451 0.473399149453327 2163 6989654
SGTC_1490 4089-0339 670 nM 0.064754681637587 0.434762639509968 no 1452 0.474184662245068 2301 742542
SGTC_3142 9086498 49.47 µM 0.0642789069759603 0.434951476174996 no 1453 0.474374074255393 2300 25236367
SGTC_1321 1326-2144 215 µM 0.0627067774555959 0.435575565298262 no 1454 0.475000000194149 2293 3513030
SGTC_2105 5350118 200 µM 0.0622556034120282 0.43575469781226 no 1455 0.47517964160101 2236 2133313
SGTC_731 3966-0296 387 µM 0.0619218829082445 0.435887205479757 no 1456 0.475312520447415 2286 660956
SGTC_2803 7707263 71.43 µM 0.0613692401157345 0.436106654648737 no 1457 0.475532574501041 2249 2199229
SGTC_606 k015-0008 38.6 µM 0.0609636300890089 0.43626773103296 no 1458 0.475694087070043 2287 1970475
SGTC_1287 0971-0001 34.6 µM 0.0606294037370558 0.436400467383532 no 1459 0.47582717789876 2271 4665869
SGTC_106 0092-0003 11.579 µM 0.059911519258378 0.436685595865341 no 1460 0.476113052667685 2302 1072148
SGTC_1349 flufenamic acid 69 µM 0.0569295979888282 0.437870302207992 no 1461 0.477300638377288 2286 3371 A non-steroidal anti-inflammatory.
SGTC_880 0833-0487 87.2 µM 0.0563410167195425 0.438104209550727 no 1462 0.477535072046225 2309 76075
SGTC_794 k038-0031 316 µM 0.0559394756740213 0.438263797887908 no 1463 0.477695011504057 2289 6624242
SGTC_1545 lovastatin 49.4 µM 0.0557464106718308 0.438340533152786 no 1464 0.477771913296055 2266 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_425 3825-7017 13.1 µM 0.0546098161713785 0.438792328839434 no 1465 0.478224659128295 2240 3397440
SGTC_1733 st037357 54.9 µM 0.0544609815515599 0.438851496437519 no 1466 0.478283947320494 2317 1272339 YGL099W LSG1
SGTC_86 0417-1630 471.922 µM 0.05107976093728 0.440196029831912 no 1467 0.479630981684359 2298 3634867
SGTC_652 0437-0092 114 µM 0.0484051412050907 0.44126007476923 no 1468 0.480696681010362 2304 3091274
SGTC_598 3937-0236 20.2 µM 0.0480231492385954 0.441412077563499 no 1469 0.480848896732166 2293 1379313
SGTC_2714 st079313 56.9 µM 0.0476381716284639 0.441565277140621 no 1470 0.481002304994935 2300 2939799
SGTC_3241 9133421 49.47 µM 0.0463441981161352 0.442080270241589 no 1471 0.481517956065394 2316 17018221
SGTC_1563 conessine 56.1 µM 0.0457986005456584 0.442297443946232 no 1472 0.481735387122418 2316 441082 An anti-amoebic, histamine inhibitor.
SGTC_2126 5251174 33.877 µM 0.0451941028139328 0.442538082957669 no 1473 0.481976297361056 2317 790722
SGTC_3269 9137823 49.47 µM 0.0446183956614257 0.442767280701573 no 1474 0.482205739821954 2284 17682936
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0424316297804684 0.443638039262953 no 1475 0.483077307064458 2294 521171
SGTC_2659 sanguinarine 24.21 µM 0.0411104011429052 0.444164277677094 no 1476 0.483603941350899 2336 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_262 fenpropimorph 62.5 µM 0.0392071086987296 0.444922521879539 no 1477 0.48436263303695 2329 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_661 1304-0007 33.6 µM 0.0391167212928959 0.444958535951079 no 1478 0.484398664754022 2307 3117130
SGTC_949 1165-0505 146 µM 0.0386837120764828 0.445131070983682 no 1479 0.484571279784634 2300 6244267
SGTC_2377 9073351 62.6 µM 0.0385434585513942 0.445186958044059 no 1480 0.484627191148009 2315 7337946 YHR072W ERG7
SGTC_1206 3978-0017 132 µM 0.0379960223588594 0.445405106288075 no 1481 0.484845426718815 2255 3873677
SGTC_1195 1502-0147 41.1 µM 0.0370068628835104 0.445799319040766 no 1482 0.485239766850272 2336 817940
SGTC_297 0986-0032 24 µM 0.0366647118608004 0.445935690028692 no 1483 0.485376172784533 2332 2847425
SGTC_90 0870-0863 4.608 µM 0.0365310064291992 0.445988982684757 no 1484 0.485429477823849 2331 1738164
SGTC_2245 6637752 200 µM 0.0355310946075931 0.44638756098909 no 1485 0.485828126055697 2331 681890
SGTC_2847 9005661 71.43 µM 0.035499941744277 0.446399979811789 no 1486 0.485840546414336 2349 2991449
SGTC_1364 1653-0028 37.6 µM 0.0349936297823714 0.44660182411006 no 1487 0.486042410230572 2304 5718652
SGTC_678 1218-2179 85.9 µM 0.0339937817921202 0.447000460092068 no 1488 0.486441054624019 2356 6820081 YOR116C RPO31
SGTC_2990 9074105 71.4286 µM 0.0336933970506158 0.447120232943378 no 1489 0.4865608221875 2354 6502001
SGTC_1008 4106-0037 6 µM 0.031745423214498 0.447897067999793 no 1490 0.487337535318884 2352 2905394
SGTC_115 0527-0192 112.043 µM 0.0312618678040386 0.44808993678188 no 1491 0.487530350308931 2253 4233931
SGTC_645 0845-0943 5.41 µM 0.0310348230864139 0.448180499074855 no 1492 0.487620884116655 2326 1885106
SGTC_2144 5628481 200 µM 0.0297436343928765 0.448695572219793 no 1493 0.488135756044379 2353 2818399
SGTC_2513 baicalein 25.65 µM 0.0292534623820526 0.44889113135432 no 1494 0.488331221320249 2328 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1297 1068-0111 14.1 µM 0.0290730640011015 0.448963106261007 no 1495 0.48840315926366 2326 767057
SGTC_2763 lisinopril 49.32 µM 0.0289782150223981 0.449000949549373 no 1496 0.4884409825953 2364 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_824 1304-0008 100 µM 0.0284114201191712 0.449227101684626 no 1497 0.488667007970526 2332 768245
SGTC_1744 st037937 38.9 µM 0.0279969170173059 0.449392499577459 no 1498 0.488832305024111 2327 1016152
SGTC_1724 st037281 8.293 µM 0.0279736979699721 0.449401764862572 no 1499 0.488841564457203 2343 574124 YDL195W SEC31
SGTC_1739 st037196 92.5 µM 0.0269062047349189 0.449827765070765 no 1500 0.489267272323764 2350 612214
SGTC_211 3455-0679 143.504 µM 0.0262295675069757 0.450097817926839 no 1501 0.48953711626551 2279 748649
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0258622610498483 0.450244423385447 no 1502 0.489683600645129 2356 6708784 An antioxidant flavonoid
SGTC_2862 9027634 71.43 µM 0.0251297049900531 0.45053683359209 no 1503 0.489975753251989 2342 5012562
SGTC_390 dec-rvkr-cmk 16.7 µM 0.024858412305623 0.450645130760704 no 1504 0.49008394957328 2335 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_553 k007-0256 45.7 µM 0.0219839397636799 0.451792813941819 no 1505 0.491230383327439 2335 6287000
SGTC_2382 9035899 200 µM 0.0216651826129351 0.451920108278864 no 1506 0.491357518749877 2365 6462679
SGTC_2215 7188065 200 µM 0.0212558592973359 0.452083577083198 no 1507 0.491520777526617 2366 940217
SGTC_2830 7992007 71.43 µM 0.0211260133425604 0.452135434520628 no 1508 0.491572566938407 2362 1952075
SGTC_1061 3448-9325 110 µM 0.0204168938885838 0.452418654629712 no 1509 0.491855403642534 2376 723482
SGTC_49 0717-0965 32.132 µM 0.0186884192662605 0.453109103179364 no 1510 0.492544833364886 2361 5889349 YGL099W LSG1
SGTC_1492 4158-0558 28.5 µM 0.0167033375205196 0.453902229632332 no 1511 0.493336642288472 2380 3967268
SGTC_1627 st003713 25.6 µM 0.014078012815901 0.454951442861162 no 1512 0.494383870974835 2361 16195070 YER133W GLC7
SGTC_2956 9076196 2.52 µM 0.0140018906714395 0.454981869864959 no 1513 0.494414236323768 2386 16423868
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0131371917865761 0.455327519668736 no 1514 0.494759169499854 2386 16486 A toxic proline analog.
SGTC_3235 9132602 49.47 µM 0.0125608585121744 0.455557918646095 no 1515 0.494989074228308 2357 4912240
SGTC_2049 5262831 67.185 µM 0.0122294713999551 0.455690403024158 no 1516 0.495121268402393 2373 763417
SGTC_1626 st003712 1.76 µM 0.0121268096078736 0.455731446911128 no 1517 0.495162221494889 2369 24207035
SGTC_19 0279-0214 38.434 µM 0.011133542866379 0.456128576409245 no 1518 0.49555845077941 2387 3566274 YBR002C RER2
SGTC_2732 terfenadine 20 µM 0.0110755817496516 0.456151751873013 no 1519 0.49558157249386 2391 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2414 st077232 92.9 µM 0.00975912635801449 0.456678170022519 no 1520 0.496106733675575 2375 729801
SGTC_1931 st074438 57.1 µM 0.00938004360230507 0.456829770038715 no 1521 0.496257958889162 2393 2787313
SGTC_487 nimodipine 119 µM 0.00781877843885697 0.45745420582607 no 1522 0.496880790480941 2397 4497 L-type voltage-gated calcium channels inhibitor
SGTC_370 0180-0345 38.7 µM 0.00699049537305106 0.457785524513948 no 1523 0.497211218548 2363 3989527
SGTC_1522 st012842 45.6 µM 0.00650419910025979 0.457980059912911 no 1524 0.497405218273973 2398 3491067 YOR116C RPO31
SGTC_2868 9035608 32.47 µM 0.00638714616043614 0.458026886659158 no 1525 0.497451914670637 2398 6462614
SGTC_2737 bleomycin 30.5 nM 0.00611376600487322 0.45813625399912 no 1526 0.497560975442549 2395 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2753 fluvastatin 17.09 µM 0.00610399927576284 0.458140161295263 no 1527 0.49756487173103 2383 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_100 0086-0128 49.5915 µM 0.00473132226285922 0.458689357123334 no 1528 0.498112482549286 2393 93297
SGTC_3129 9127257 49.47 µM 0.00457736571852915 0.458750958701168 no 1529 0.498173901658841 2393 837894
SGTC_2921 7974240 10.71 µM 0.00421638438166621 0.45889539957323 no 1530 0.498317910983732 2393 2979074 YDR527W RBA50
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.00290508290456845 0.459420141277391 no 1531 0.49884104123147 2399 641818 YHR062C RPP1
SGTC_2832 7992762 51.95 µM 0.00188390287755957 0.459828834497362 no 1532 0.499248431934535 2399 2985177
SGTC_405 ebelactone b 50 µM 0.00175755921428726 0.459879402291025 no 1533 0.499298835680096 2396 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_708 3448-5400 146 µM 0.00171063750160577 0.459898182404801 no 1534 0.499317554707007 2403 3462195
SGTC_428 3448-4153 16.5 µM 0.00108602369656017 0.460148188570252 no 1535 0.499566739315092 2403 3834874
SGTC_1280 0880-0253 10.1 µM 0.000814239662723629 0.460256977008827 no 1536 0.499675165408053 2403 6836607
SGTC_2186 6124449 200 µM 0 0.460582914818521 no 1537 0.5 2405 3834182 YLR033W RSC58
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.000478210483905495 0.460774353467671 no 1538 0.49980922162631 2406 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2442 5158906 48.48 µM -0.00255088325694589 0.46160419655308 no 1539 0.498982345920083 2413 1893835
SGTC_907 3448-6986 75.5 µM -0.00263459047492147 0.461637714234912 no 1540 0.498948951683911 2411 590582
SGTC_2384 9036245 200 µM -0.00264987304009393 0.461643833642917 no 1541 0.498942854843793 2437 6462766
SGTC_722 3534-0461 190 µM -0.00289268253837514 0.461741060055765 no 1542 0.498845988241051 2415 658262
SGTC_2981 9013952 38.96 µM -0.0032657234734119 0.461890438533154 no 1543 0.498697167146131 2417 2996344
SGTC_1816 st051957 91.6 µM -0.00332126860325342 0.461912681182331 no 1544 0.498675007965552 2413 674121
SGTC_402 epigallocatechin gallate 10 µM -0.00350389392350974 0.461985813022331 no 1545 0.498602151428166 2415 65064 An antioxidant.
SGTC_505 gw-5074 63.9 µM -0.00402516545443491 0.462194561928181 no 1546 0.498394195650811 2419 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2053 5265679 138 µM -0.00468043949416098 0.462456988376065 no 1547 0.498132781612295 2418 764595
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.00534417469988867 0.462722820041465 no 1548 0.497867992906794 2434 61125 An anti-inflammatory.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.00591929980983585 0.462953176068389 no 1549 0.497638554825588 2425 75037 A free radical scavenger.
SGTC_2696 st077691 74.316 µM -0.00598245361837401 0.462978471949847 no 1550 0.497613360547304 2431 757133
SGTC_1778 st046819 58.9 µM -0.00601212938327519 0.462990358452245 no 1551 0.497601521842888 2416 671715
SGTC_1084 voriconazole 435 nM -0.00613531370489962 0.463039699765587 no 1552 0.497552379315185 2422 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2201 6605497 169.863 µM -0.00640122416451547 0.463146211777961 no 1553 0.497446298474398 2426 670741
SGTC_1609 st001574 46.4 µM -0.0103379383722428 0.464723391025386 no 1554 0.495875832751592 2422 3960012
SGTC_2389 9091542 195.52 µM -0.0103716854594412 0.464736913668125 no 1555 0.495862370333423 2440 3626624 YOL127W RPL25
SGTC_301 4119-0100 24.5 µM -0.0105146429114505 0.464794197953908 no 1556 0.495805341671415 2430 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_210 3551-0445 56.827 µM -0.0116962893912809 0.465267721737264 no 1557 0.495333962026393 2418 2865180 YOR207C RET1
SGTC_1302 1159-0335 255 µM -0.0123308045903805 0.465522012743049 no 1558 0.495080845356391 2428 649284
SGTC_1825 st052143 62.6 µM -0.0131081764681352 0.465833574778143 no 1559 0.494770743940529 2429 674173
SGTC_2970 9090938 41.86 µM -0.013503072851871 0.465991852906488 no 1560 0.494613217022574 2435 17217104
SGTC_376 3970-0862 59.1 µM -0.0144098076732024 0.466355300937171 no 1561 0.494251517405666 2444 3135186
SGTC_791 1348-1292 225 µM -0.0145518204930629 0.466412226721765 no 1562 0.494194868427298 2489 5437054
SGTC_2664 lyso-paf C-16 73.48 µM -0.0151574388480027 0.466654996307189 no 1563 0.493953288318424 2438 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2673 kobusone 100 µM -0.015701210050943 0.466872984272413 no 1564 0.493736380817854 2435 6710676 An epoxy ketone and protein crosslinker.
SGTC_528 3492-0019 172 µM -0.0162019235372761 0.467073719973011 no 1565 0.493536650452435 2428 2869262
SGTC_246 cycloheximide 667 µM -0.016382284965373 0.467146028802751 no 1566 0.493464706201922 2424 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1731 st035964 63 µM -0.0187550791395686 0.468097407482679 no 1567 0.492518244583167 2478 6739575
SGTC_1325 1431-0015 227 µM -0.0203916558425619 0.468753704163934 no 1568 0.491865470070449 2436 1103340
SGTC_2619 obliquin 87.91 µM -0.020559365178214 0.468820963449786 no 1569 0.491798577749374 2447 6708593 A bioactive alkalod. YER133W GLC7
SGTC_133 0724-0033 378.92 µM -0.0211103846285274 0.469041954270196 no 1570 0.491578800503051 2433 280309
SGTC_3280 9140961 49.47 µM -0.0224850366868493 0.469593311061475 no 1571 0.491030523988881 2448 4901226
SGTC_91 0417-1751 58.384 µM -0.0262270619214922 0.471094485767857 no 1572 0.489538115505737 2452 6795624
SGTC_752 1896-0090 130 µM -0.0271712205102531 0.471473316191767 no 1573 0.48916158496697 2458 772567
SGTC_2950 9072895 21.46 µM -0.0278550118264156 0.471747694026752 no 1574 0.488888894934126 2471 17332245
SGTC_3232 9132874 49.47 µM -0.0291169708594984 0.472254102326436 no 1575 0.488385650373829 2468 3784940
SGTC_2780 5215298 71.43 µM -0.0294118196774847 0.472372427945986 no 1576 0.488268073072099 2461 2834131
SGTC_2972 9093619 59.92 µM -0.0310419698187326 0.473026666338888 no 1577 0.487618034356001 2465 25236256
SGTC_2867 9039098 71.43 µM -0.0311355013780633 0.473064206171157 no 1578 0.487580738690109 2464 6463460
SGTC_796 1234-0020 70.7 µM -0.0312373437474118 0.473105081902685 no 1579 0.487540129216104 2458 46495034
SGTC_1432 4049-0298 68.4 µM -0.031285579006061 0.473124441836701 no 1580 0.487520895532658 2479 741646
SGTC_559 1550-0661 158 µM -0.0315859340075413 0.473244995182665 no 1581 0.48740113041486 2498 5830875
SGTC_1505 k297-0037 20.6 µM -0.0319061294795325 0.473373514587363 no 1582 0.487273455256032 2466 4089396
SGTC_2167 5876490 200 µM -0.0322037464386154 0.473492973960278 no 1583 0.48715478425215 2566 686534
SGTC_1812 st052057 4.327 µM -0.0324657933461718 0.4735981579753 no 1584 0.487050297298362 2458 3645418
SGTC_3048 9093155 49.47 µM -0.0349576851654622 0.474598478948659 no 1585 0.48605674128976 2462 25236002
SGTC_1805 st050013 60.3 µM -0.0356412258351669 0.474872901168713 no 1586 0.485784217863566 2497 4037144
SGTC_2843 9000894 45.46 µM -0.0362969697190843 0.4751361749723 no 1587 0.485522783081572 2462 2242070
SGTC_634 1611-4317 11.2 µM -0.0391820160071826 0.476294616068238 no 1588 0.484372635886328 2471 2843522
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0395503035256295 0.476442510262881 no 1589 0.484225824225402 2472 688662
SGTC_2294 7971431 200 µM -0.0408210605735202 0.476952836326409 no 1590 0.483719274720729 2519 5741572
SGTC_2949 9072542 2.23 µM -0.0415839351700662 0.477259218992171 no 1591 0.483415190020529 2520 16457352
SGTC_320 4092-0846 5.34 µM -0.0418826609303701 0.477379195718094 no 1592 0.48329611942084 2555 1359356
SGTC_2811 7967822 32.47 µM -0.0441992626184738 0.478309677340129 no 1593 0.482372784912944 2531 2232244
SGTC_2142 5622915 118.518 µM -0.0446255889189564 0.478480927745672 no 1594 0.482202872982926 2505 5322196
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0447943717546178 0.478548726982548 no 1595 0.48213560564038 2505 115019
SGTC_1507 4075-3230 155 µM -0.0451023458963479 0.47867244028242 no 1596 0.482012865786141 2458 659771
SGTC_493 zm226600 134 µM -0.045307848316634 0.478754991806586 no 1597 0.481930965906109 2582 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1633 st005664 67.9 µM -0.0467615896112009 0.479338994011192 no 1598 0.481351621287456 2491 2063822
SGTC_662 k832-1615 104 µM -0.0471412430972329 0.479491517136715 no 1599 0.481200328310624 2527 5878478
SGTC_2094 5332512 191.667 µM -0.0473550321710766 0.479577406720925 no 1600 0.481115133956596 2534 755774
SGTC_156 3474-0145 5.642 µM -0.0479251438030195 0.479806453224487 no 1601 0.48088795027701 2474 2265471
SGTC_2136 5328288 199.296 µM -0.0484570696084483 0.480020164308456 no 1602 0.480675988856415 2499 262395
SGTC_3256 9138902 49.47 µM -0.0498746775361128 0.48058974253795 no 1603 0.480111128290979 2479 17228773
SGTC_373 0844-0104 25.9 µM -0.0505366336793681 0.480855722392367 no 1604 0.479847378616776 2509 5375804
SGTC_1013 4112-3890 241 µM -0.0517642378683781 0.481349007123006 no 1605 0.479358275687948 2493 705171
SGTC_1771 st048882 4.1505 µM -0.052194689949826 0.481521981270693 no 1606 0.47918678198724 2494 4580403
SGTC_1410 3909-8106 77.9 µM -0.0523840077018593 0.481598058383957 no 1607 0.479111358312949 2527 1039210
SGTC_1079 idarubicin 2.36 µM -0.0545864335680684 0.482483149122005 no 1608 0.478233973544102 2494 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_562 3772-2733 112 µM -0.0550809489643269 0.482681892465156 no 1609 0.478036986812269 2518 2876874 YIL048W NEO1
SGTC_1591 genipin 88.4 µM -0.0557626831737011 0.482955885188309 no 1610 0.477765431589303 2645 442424 A DNA cross-linking agent.
SGTC_1554 st069299 38.7 µM -0.055884432801503 0.4830048178833 no 1611 0.477716936136531 2552 24207999
SGTC_2110 5483698 200 µM -0.056822813449852 0.483381973312956 no 1612 0.477343170395621 2542 2848765 YHR062C RPP1
SGTC_1600 coumarin 106 71.1 µM -0.0583180511484544 0.4839829721936 no 1613 0.476747644623776 2659 100336 A hepatotoxic, DNA x-linker.
SGTC_2281 7943571 200 µM -0.0583606664466007 0.48400010161303 no 1614 0.476730672486315 2528 1244024
SGTC_1342 1486-1464 234 µM -0.0584400748312884 0.484032020265317 no 1615 0.476699047101085 2496 3253938
SGTC_1186 1319-0216 26 µM -0.058590963666111 0.484092671173242 no 1616 0.47663895413455 2578 4565136
SGTC_2719 novobiocin 32.65 µM -0.0605339627993477 0.484873706753573 no 1617 0.475865183517071 2520 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1375 2910-0797 186 µM -0.0605702243554577 0.484888283525643 no 1618 0.475850743745583 2552 742508
SGTC_1546 5-methoxyflavanone 78.7 µM -0.0606655966987593 0.484926622321689 no 1619 0.475812765525685 2524 147795
SGTC_1807 st050092 58.9 µM -0.0607684472192524 0.484967967431646 no 1620 0.475771809667186 2521 5008496
SGTC_3067 9117431 49.47 µM -0.0611700083300887 0.485129393420662 no 1621 0.475611907437362 2535 17150885
SGTC_361 000s-0510 1.45 µM -0.061217172285808 0.485148353306014 no 1622 0.475593126937507 2565 660
SGTC_925 2064-1272 59.6 µM -0.0619262354799735 0.485433400359198 no 1623 0.475310787348573 2548 6815817
SGTC_1130 3454-2858 15.9 µM -0.062274387267943 0.485573361903319 no 1624 0.47517216243885 2606 715628 YIL048W NEO1
SGTC_249 wiskostatin 11.211 µM -0.0622756841041316 0.485573883251657 no 1625 0.475171646078305 2498 2775510 A n-wasp and actin depolymerizer.
SGTC_2033 5192550 145 µM -0.0622776450049356 0.485574671564355 no 1626 0.475170865307599 2536 182073
SGTC_2413 inermin 26.06 µM -0.0634502610380215 0.486046091480339 no 1627 0.47470398266335 2689 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1124 fisetin 1.16336 µM -0.0635707625036535 0.486094537090833 no 1628 0.474656006389715 2594 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_41 0478-0632 82.643 µM -0.0636376897109421 0.486121444150312 no 1629 0.474629360250019 2497 3750424
SGTC_2015 5119600 184 µM -0.0657400921775649 0.486966714423694 no 1630 0.4737923762465 2571 2828786
SGTC_2969 9091408 28.7 µM -0.0661154824139769 0.487117646224596 no 1631 0.473642942318838 2568 4286311
SGTC_832 4083-0019 164 µM -0.0663312304824872 0.487204392110162 no 1632 0.473557059819448 2607 1990758
SGTC_1272 0839-0021 27 µM -0.0663716357153169 0.487220637920729 no 1633 0.473540975907533 2593 5027250
SGTC_3155 9099265 49.47 µM -0.0665842816355743 0.487306137228414 no 1634 0.47345632970543 2584 25236499
SGTC_2982 9019404 25.97 µM -0.0679351118123468 0.487849283823104 no 1635 0.47291864406071 2539 22333232
SGTC_547 1120-0019 610 nM -0.0685590598465683 0.488100170734689 no 1636 0.472670303829826 2516 3676939
SGTC_1578 josamycin 24.2 µM -0.0705635170509486 0.488906186015664 no 1637 0.471872573589296 2537 5282165 A P450 substrate.
SGTC_1174 0739-0097 51.1 µM -0.0709500000276281 0.489061600575006 no 1638 0.471718774671069 2562 728447
SGTC_3353 9151644 39.2805 µM -0.0723645836924757 0.489630454355548 no 1639 0.47115588449661 2597 4909158
SGTC_2874 9043904 71.43 µM -0.0724753550197779 0.489675000302793 no 1640 0.471111808863072 2605 4463428
SGTC_818 4072-2707 53.5 µM -0.0727669353215151 0.489792257982156 no 1641 0.470995791484702 2551 882871
SGTC_1004 4084-0029 199 µM -0.0741114783106988 0.490332971026929 no 1642 0.470460841004293 2574 716894 YLR208W SEC13
SGTC_1902 st060212 70.5 µM -0.0749135634488974 0.490655541120698 no 1643 0.470141742405599 2549 688944
SGTC_806 3966-4455 5.86 µM -0.0750553549575455 0.490712565260364 no 1644 0.470085334582229 2564 714982
SGTC_2274 7947094 46.08 µM -0.0751096241043219 0.490734390675482 no 1645 0.470063745264503 2539 2971028
SGTC_1355 1499-0035 1.68 µM -0.0755415902152417 0.490908115409315 no 1646 0.469891903922011 2555 1548538
SGTC_1067 clotrimazole 1.36 µM -0.0787039942473364 0.49217999661372 no 1647 0.468634034194041 2561 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3332 9141069 11.198 µM -0.0804263270350788 0.492872732598982 no 1648 0.467949094388398 2549 17332883
SGTC_2718 lomofungin 53.02 µM -0.0804870310997162 0.49289714866239 no 1649 0.467924955226743 2602 5351222 A RNA synthesis inhibitor.
SGTC_526 4469-0568 170 µM -0.0807993691509718 0.493022776017441 no 1650 0.467800754887769 2545 2901964
SGTC_1981 st071826 47 µM -0.0825738812825555 0.493736525917111 no 1651 0.46709518502465 2617 11838600
SGTC_1449 4112-4002 201 µM -0.0843618969301916 0.494455727520075 no 1652 0.466384350549198 2589 2059539
SGTC_2612 dictamnine 15.46 µM -0.0844267856615558 0.49448182836032 no 1653 0.466358555715126 2641 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.085796746002552 0.495032886482707 no 1654 0.465813996627859 2541 368090
SGTC_2739 tacrine 100.86 µM -0.0862335234513422 0.495208579568339 no 1655 0.465640391046556 2633 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2983 9022671 12.99 µM -0.0863804143675273 0.495267666433613 no 1656 0.465582007899872 2761 6405161
SGTC_1992 st073643 23.3 µM -0.0864695551150812 0.495303523346521 no 1657 0.465546578450366 2552 3161292
SGTC_439 amiodarone 34.4 µM -0.088285564204617 0.496034021817665 no 1658 0.464824856123663 2647 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1954 st077032 68.9 µM -0.0888364155669606 0.496255607193159 no 1659 0.464605958326178 2653 698907
SGTC_2361 9034121 116 µM -0.0890231949315625 0.496330741294336 no 1660 0.46453173820695 2606 6496917
SGTC_206 4546-0025 72.014 µM -0.0892224466232581 0.49641089267285 no 1661 0.464452563346132 2584 6620745 YIL048W NEO1
SGTC_802 4112-3352 742 µM -0.0898101919788996 0.496647321110651 no 1662 0.464219024447593 2710 704594
SGTC_1284 0929-0043 16 µM -0.0899049806081417 0.496685451218201 no 1663 0.464181361615167 2629 1239883
SGTC_2258 7960471 200 µM -0.0905573351334289 0.496947871136113 no 1664 0.463922167105381 2631 2974708
SGTC_3348 9149464 3.537 µM -0.0916174381448963 0.497374317093244 no 1665 0.463500998042602 2547 1951442
SGTC_1159 4092-0538 61.2 µM -0.0919321714438469 0.497500924957849 no 1666 0.463375965284785 2564 717301
SGTC_3278 9139605 49.47 µM -0.0921179569026943 0.497575661052628 no 1667 0.463302160783699 2779 7958859
SGTC_3118 9124250 49.47 µM -0.0921643099252202 0.497594307540836 no 1668 0.463283746936012 2640 1504786
SGTC_407 eburnamonine 100 µM -0.092677921666758 0.497800919119553 no 1669 0.463079718732267 2568 3195
SGTC_3308 9128332 17.569 µM -0.0932652904295247 0.498037201796163 no 1670 0.46284640304178 2658 17332805 YDL196W YDL196W
SGTC_1341 1486-1360 280 µM -0.0933236423262494 0.498060675235848 no 1671 0.46282322509163 2559 3976547
SGTC_1428 4049-0204 61.7 µM -0.0938111188979245 0.498256774547085 no 1672 0.462629599518099 2661 X1428
SGTC_443 clozapine 122 µM -0.094401356438401 0.498494212517482 no 1673 0.462395169168467 2558 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_469 w7 172 µM -0.0945360043884207 0.498548378136694 no 1674 0.462341691567384 2557 45115570 A P450 inhibitor.
SGTC_1552 6-methylflavone 10.6 µM -0.0945783858132039 0.498565427166168 no 1675 0.462324859243027 2580 689013
SGTC_2343 7990716 14.84 µM -0.0946931658961743 0.498611600450368 no 1676 0.462279273205422 2597 6456862
SGTC_1675 st018485 24.5 µM -0.09660826369127 0.499382000790434 no 1677 0.461518746859494 2650 3323024
SGTC_309 k408-0051 1.48 µM -0.096633610700735 0.499392197338355 no 1678 0.461508681956538 2596 3640463
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0996554113563488 0.499392197338355 no 1679 0.460308950416954 2573 1377
SGTC_3219 9131112 49.47 µM -0.0997542949193055 0.499352418644496 no 1680 0.46026969717793 2589 17612988 YMR079W SEC14
SGTC_2954 9074818 52.69 µM -0.100505552270716 0.499050204487798 no 1681 0.459971487542408 2660 16648742
SGTC_3162 9099653 49.47 µM -0.101208659394573 0.498767360589265 no 1682 0.459692411407456 2587 25237511
SGTC_1843 st055809 45.5 µM -0.101391852838528 0.498693666156906 no 1683 0.459619701819492 2699 16413835
SGTC_2784 7567673 72.73 µM -0.101495393129598 0.498652014342139 no 1684 0.459578607212972 2575 3471247
SGTC_107 0358-0022 2.6945 µM -0.101510068964904 0.498646110601234 no 1685 0.459572782484704 2669 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2432 5630864 12.22 µM -0.102980878190019 0.498054440611 no 1686 0.458989073624923 2706 5714970
SGTC_2453 5731132 22.18 µM -0.104898465658581 0.497283049464017 no 1687 0.458228188239774 2674 1362040
SGTC_1261 0712-0010 12.7 µM -0.105038207424627 0.497226835670236 no 1688 0.458172745627025 2634 2840123
SGTC_3025 9087895 49.47 µM -0.105983190045867 0.496846699867687 no 1689 0.457797844731167 2634 17173641
SGTC_1994 st072947 40.9 µM -0.107203100227808 0.496355973924114 no 1690 0.457313927989847 2717 5286565 YDL195W SEC31
SGTC_3204 9114183 49.47 µM -0.107401618769014 0.496276117564655 no 1691 0.457235185172178 2582 17027248
SGTC_2585 alliin 100 µM -0.108523617872035 0.495824783458576 no 1692 0.456790173399126 2700 87310 A garlic compound which reacts with lipids.
SGTC_691 1548-0686 185 µM -0.108780543419276 0.495721433605993 no 1693 0.456688278164877 2610 46495133
SGTC_2242 6630449 61.2675 µM -0.108870306525809 0.495685325921775 no 1694 0.456652679290085 2780 691249 YDR170C SEC7
SGTC_719 2810-4230 27.3 µM -0.109062276125769 0.495608105254177 no 1695 0.456576547823838 2597 721079
SGTC_1108 betulinic acid 729.144 nM -0.109397774887288 0.49547314970827 no 1696 0.456443499270023 2609 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1122 capsaicin 818.572 nM -0.109679629104811 0.495359773266921 no 1697 0.456331728276424 2730 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3042 9091578 49.47 µM -0.110961013131228 0.494844338756525 no 1698 0.455823631387313 2580 25236497
SGTC_1178 0988-0033 191 µM -0.112751461260838 0.49412414869638 no 1699 0.455113800577759 2727 5392207
SGTC_922 1866-0035 480 µM -0.113591091434837 0.493786422212488 no 1700 0.454780974822769 2614 3156169
SGTC_887 0885-0007 9.62 µM -0.114225513516167 0.493531240018911 no 1701 0.454529513705092 2758 5719458
SGTC_3074 9116018 49.47 µM -0.114408557732937 0.493457615035037 no 1702 0.454456965225788 2587 17027303
SGTC_144 4161-2749 112.381 µM -0.114722288531901 0.493331425143391 no 1703 0.454332623437036 2598 797501 YMR168C CEP3
SGTC_1370 2001-0092 44.6 µM -0.114761800008084 0.493315532747258 no 1704 0.454316964062268 2670 790957
SGTC_1952 st077036 64.1 µM -0.114911760510224 0.493255215388576 no 1705 0.454257531654484 2594 2937007
SGTC_2006 4011487 200 µM -0.115281485974546 0.493106504468684 no 1706 0.454111006284599 2698 45595294
SGTC_2635 hydroquinidine 100 µM -0.115731913967389 0.492925334686661 no 1707 0.453932506251696 2626 442912 An experimental heart treatment.
SGTC_2671 danthron 100 µM -0.116146598009273 0.492758543017568 no 1708 0.453768179408708 2648 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1770 st043884 66.3 µM -0.116434922889814 0.492642575498886 no 1709 0.453653929572667 2612 670149
SGTC_76 0433-0009 400.328 µM -0.116873276895118 0.492466265768825 no 1710 0.453480237473864 2773 2841569
SGTC_3137 9097352 49.47 µM -0.11845419257086 0.491830420436861 no 1711 0.452853894259493 2846 44120435
SGTC_1281 0884-0031 11.8 µM -0.118977779531872 0.491619837910895 no 1712 0.452646480042106 2618 1548255
SGTC_2339 9000433 200 µM -0.119252999245166 0.491509147656288 no 1713 0.452537459430485 2676 2988954
SGTC_1401 3807-4679 7.6 µM -0.119700194846794 0.491329292043422 no 1714 0.452360323002297 2609 3291456
SGTC_1924 st058459 75.1 µM -0.119750330287824 0.491309128402285 no 1715 0.452340464692259 2611 688683
SGTC_157 1348-1695 65.819 µM -0.12224726524854 0.49030493181602 no 1716 0.451351597439156 2626 5380510
SGTC_1666 st014829 29 µM -0.122269455319509 0.49029600786343 no 1717 0.451342810795092 2593 3858230
SGTC_170 4197-0004 226 µM -0.122925048380703 0.490032356956522 no 1718 0.451083225154688 2740 218692
SGTC_2300 7976697 71.57 µM -0.124146963898769 0.489540967594103 no 1719 0.450599456969229 2656 2236109
SGTC_1283 0922-0125 16.4 µM -0.124875144467415 0.489248139641484 no 1720 0.450311198080649 2714 3360884
SGTC_1043 0916-0009 19.3 µM -0.1254741783127 0.489007250632254 no 1721 0.450074083092947 2614 3101130
SGTC_1550 gossypolone 36.6 µM -0.1263894620492 0.488639196076893 no 1722 0.449711821663302 2643 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_625 k213-0058 121 µM -0.126610879288676 0.488550161058479 no 1723 0.44962419290798 2685 3655420
SGTC_329 k048-0121 21.3 µM -0.128828653965911 0.487658394561557 no 1724 0.448746615934731 2711 6832902
SGTC_2455 5377712 9.75 µM -0.128922759937125 0.487620555913458 no 1725 0.448709383566633 2696 2243908
SGTC_1378 2093-0007 380 nM -0.129506066888442 0.48738601913555 no 1726 0.44847861234864 2717 3618014
SGTC_73 0327-0325 16.231 µM -0.130523481997152 0.486976946103399 no 1727 0.448076138554827 2814 53298
SGTC_3333 9141820 12.094 µM -0.131497947476775 0.486585154709307 no 1728 0.44769070507642 2681 1939433
SGTC_1955 wogonin 32.4 µM -0.13199644504461 0.486384734882995 no 1729 0.447493551794858 2900 5281703 A flavanone.
SGTC_3099 9120367 49.47 µM -0.132658971414513 0.48611837297658 no 1730 0.447231546032216 2632 24824940
SGTC_3246 9135460 32.98 µM -0.133316989231737 0.485853829817072 no 1731 0.446971346034727 2634 41446951
SGTC_720 r052-1644 49.9 µM -0.133749352733287 0.485680009931928 no 1732 0.446800388946585 2763 1422863 YOR257W CDC31
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.134887439751321 0.485222486358779 no 1733 0.446350435207459 2653 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1413 3910-0535 34.4 µM -0.13501654016687 0.485170587780619 no 1734 0.446299398457381 2766 2876951
SGTC_2185 6113692 200 µM -0.135220552542725 0.485088574984387 no 1735 0.446218748876139 2749 874150
SGTC_1900 st060200 72.8 µM -0.135443859940414 0.484998806329484 no 1736 0.446130474193298 2627 688945
SGTC_2341 7987486 176.74 µM -0.135717713771911 0.484888719254535 no 1737 0.446022221863266 2726 1258686
SGTC_2152 5568786 200 µM -0.136059974693296 0.484751134690573 no 1738 0.445886934389837 2622 5399883
SGTC_2257 7960413 200 µM -0.13629767978517 0.484655581315674 no 1739 0.445792979015959 2666 2974689 YIL048W NEO1
SGTC_1424 4048-1941 275 µM -0.137863140291601 0.484026315274201 no 1740 0.44517429098295 2752 X1424
SGTC_2354 9060492 162 µM -0.138676530256214 0.483699373616956 no 1741 0.444852882507971 2774 6471895
SGTC_560 2332-1943 155 µM -0.138818471092173 0.483642321691487 no 1742 0.444796798744239 2647 21177716
SGTC_2885 9057732 51.95 µM -0.13905507575296 0.483547221182638 no 1743 0.444703313799792 2780 6471414
SGTC_2622 2-methoxyxanthone 59.94 µM -0.139662514187941 0.483303072623198 no 1744 0.444463322698829 2734 71034 A hepatoprotective.
SGTC_3158 9100007 49.47 µM -0.139693228316295 0.483290727817173 no 1745 0.444451188482367 2678 19297233
SGTC_2977 9011197 71.43 µM -0.139786158398459 0.483253376900773 no 1746 0.444414474954965 2877 2704722
SGTC_2369 9071472 200 µM -0.141682517579844 0.482491215438795 no 1747 0.443665392286275 2797 17296037
SGTC_2286 7945697 125 µM -0.142834408939412 0.482028292425424 no 1748 0.443210480643531 2738 1245733
SGTC_2851 9015922 71.43 µM -0.144406210772441 0.481396654669074 no 1749 0.44258985636401 2807 2996893
SGTC_2420 aureobasidin a 50 nM -0.144958885989637 0.481174569917344 no 1750 0.4423716665364 2960 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2367 9070478 135.38 µM -0.145498694955605 0.480957660926964 no 1751 0.442158573030469 2662 572802
SGTC_1841 st054148 70 µM -0.14740933342519 0.480189963457381 no 1752 0.441404469496703 2740 675442
SGTC_321 4534-3890 65.3 µM -0.148170930845349 0.479883972766291 no 1753 0.441103936192343 2782 699746
SGTC_1217 1183-1422 255 µM -0.14839238582343 0.479794999941705 no 1754 0.441016554390044 2785 2849664
SGTC_2010 4012422 159 µM -0.149486208149797 0.479355555437024 no 1755 0.440584995696495 2743 952393
SGTC_1564 D-Arginine 115 µM -0.149597449484515 0.479310865486704 no 1756 0.440541110277882 2709 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3065 9113888 49.47 µM -0.149993500270071 0.479151758670242 no 1757 0.440384871640121 2841 16648368
SGTC_1914 st062367 72.6 µM -0.150161272608357 0.479084359923761 no 1758 0.440318689688885 2701 978205
SGTC_721 1187-1332 279 µM -0.150433479159961 0.478975008364729 no 1759 0.440211314625332 2643 25730
SGTC_850 0388-0143 75.9 µM -0.152403028745328 0.478183843188331 no 1760 0.439434534195163 2694 67273
SGTC_2048 5246248 200 µM -0.152490007743509 0.478148905811597 no 1761 0.439400235470031 2706 677046
SGTC_2362 9071156 126 µM -0.152550132179555 0.478124755366308 no 1762 0.439376526661917 2840 653133
SGTC_384 k007-0144 5.16 µM -0.152999225358099 0.477944368691138 no 1763 0.439199443086584 2743 6824886
SGTC_2335 9018011 154.17 µM -0.153361032969907 0.477799045181172 no 1764 0.439056786250734 2794 6458208
SGTC_1054 3429-0080 167 µM -0.154438946171215 0.477366108541519 no 1765 0.438631823701287 2805 1162877
SGTC_908 3448-7491 47.7 µM -0.154943829973994 0.477163334488091 no 1766 0.438432799774432 2705 1203031
SGTC_999 SEC7.066 22.7 µM -0.15570586304476 0.476857294024313 no 1767 0.438132437750395 2704 740511 YDR170C SEC7
SGTC_2406 ethylparaben 405.7 µM -0.155960887820706 0.476754876442204 no 1768 0.438031925446712 2669 8434 A possible steroid mimic.
SGTC_657 3534-0529 86.7 µM -0.156175435804196 0.476668715470519 no 1769 0.437947369260248 2831 1049549
SGTC_2749 bexarotene 57.39 µM -0.156289793252217 0.476622790763492 no 1770 0.437902300640877 2790 82146 An retinoic acid receptor inhibitor.
SGTC_870 0573-2213 57.6 µM -0.156773278214701 0.476428631901019 no 1771 0.437711766649803 2664 3916321
SGTC_2205 7238770 200 µM -0.156875633164443 0.476387528710883 no 1772 0.437671431988417 2776 279867
SGTC_3263 9137018 49.47 µM -0.157260094300837 0.476233140973301 no 1773 0.437519934505255 2711 43844957
SGTC_701 4424-0219 185 µM -0.159139540215813 0.475478465228609 no 1774 0.436779468282535 2777 2911779
SGTC_3138 9097216 49.47 µM -0.16016563463906 0.475066482566936 no 1775 0.436375299729409 2635 25237486
SGTC_1372 2752-0194 270 µM -0.160645988832297 0.474873626800318 no 1776 0.436186115711791 2680 823334
SGTC_1020 4335-0961 93.3 µM -0.161148918046136 0.474671713775195 no 1777 0.435988056330051 2661 669075
SGTC_1842 st055362 61.2 µM -0.162141951894256 0.47427305561347 no 1778 0.435597035217959 2707 676032
SGTC_135 0933-0004 26.348 µM -0.163267461299049 0.473821245674864 no 1779 0.435153926115331 2791 21230617 YGL099W LSG1
SGTC_847 0342-0274 5.54 µM -0.163301560911155 0.473807557690207 no 1780 0.43514050248569 2817 18097
SGTC_2965 9082772 38.63 µM -0.163514473922678 0.473722092607563 no 1781 0.435056688988355 2796 16459634
SGTC_2735 sertaconazole 140 nM -0.16356766239671 0.473700742493127 no 1782 0.435035751728383 2686 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3206 9114350 49.47 µM -0.164620626793263 0.473278093047601 no 1783 0.434621297443867 2799 17087243
SGTC_1853 st056710 91.2 µM -0.164847515509177 0.473187026094439 no 1784 0.434532001821358 2882 269167
SGTC_1335 1486-0900 202 µM -0.164971889152052 0.473137106494796 no 1785 0.434483054035019 2678 X1335
SGTC_2852 9023854 51.95 µM -0.165351128605064 0.472984894523709 no 1786 0.434333808907294 2849 19798528
SGTC_354 2783-3500 4.88 µM -0.166835708215106 0.472389080142631 no 1787 0.433749660667457 2730 6740761
SGTC_709 3807-1509 243 µM -0.170822117011527 0.470789502446068 no 1788 0.43218181890937 2687 1886677 YPL242C IQG1
SGTC_992 3909-8734 162 µM -0.171039830937141 0.470702156366278 no 1789 0.432096223239252 2755 4288319
SGTC_1109 tnp00067 928.257 nM -0.171069213677464 0.470690368219555 no 1790 0.432084671464538 2732 676295
SGTC_1197 1601-0112 267 µM -0.171684741412673 0.470443428784202 no 1791 0.43184269113907 2707 7350313
SGTC_1539 benzyladenosine 56 µM -0.171943466254936 0.470339636090703 no 1792 0.431740987149323 2698 92208 A nucleotide analog.
SGTC_1916 st067606 49.2 µM -0.173070921729851 0.469887358181407 no 1793 0.43129784055415 2825 19590279
SGTC_3272 9137413 49.47 µM -0.173488665800365 0.469719790296421 no 1794 0.431133668089368 2707 17614870
SGTC_2777 climbazole 1.536 µM -0.173907386342391 0.469551836105076 no 1795 0.430969123813065 2740 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2680 butyl paraben 22.24 µM -0.17460940034155 0.469270261437258 no 1796 0.430693280830879 2705 7184 An antifungal and steroid mimetic.
SGTC_1602 st001878 87.6 µM -0.174922869903362 0.469144535156289 no 1797 0.430570119869904 2908 595405 YLR310C CDC25
SGTC_2398 5228213 48.84 µM -0.175285592543975 0.468999058305406 no 1798 0.430427615996325 2828 80771 YMR134W ERG29
SGTC_1429 4049-0205 9.46 µM -0.176296439929549 0.468593660532428 no 1799 0.430030529378212 2705 22774478
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.176479030533646 0.468520436495032 no 1800 0.429958810668387 2734 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_265 mycophenolic acid 32.932 µM -0.177546789918059 0.46809225594512 no 1801 0.429539457967429 2964 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1252 0493-0875 34.8 µM -0.179221148377884 0.46742089854023 no 1802 0.42888202928176 2706 3960963
SGTC_549 1661-1316 519 µM -0.179941022605697 0.467132283289166 no 1803 0.428599434706025 2803 2857282
SGTC_1021 4476-0760 85.3 µM -0.179956134167019 0.467126224877883 no 1804 0.428593502887551 2742 746768
SGTC_3165 9101544 49.47 µM -0.180215791978584 0.467022126050117 no 1805 0.428491580599419 2833 5002184
SGTC_2317 5986382 200 µM -0.18066815520457 0.466840775521192 no 1806 0.428314027936028 2789 877883
SGTC_3110 9122132 49.47 µM -0.180978469869126 0.466716375645904 no 1807 0.428192237752459 2869 918317
SGTC_829 1635-0120 117 µM -0.181869103014314 0.466359354053055 no 1808 0.427842726153444 2872 285054
SGTC_1784 st039334 36.3 µM -0.18192255302765 0.466337928795393 no 1809 0.427821752536591 2975 3496984
SGTC_2695 st077686 51.995 µM -0.182542095740422 0.466089594321995 no 1810 0.427578660824738 2786 2876092
SGTC_77 0828-0286 12.516 µM -0.182594577970931 0.466068558206416 no 1811 0.427558069486496 2687 745345
SGTC_3239 9133757 49.47 µM -0.183009606400891 0.46590220836866 no 1812 0.427395240549863 2726 17036923
SGTC_1802 st050112 57.9 µM -0.183785035621779 0.465591420284773 no 1813 0.427091048007682 2704 4662563
SGTC_172 1112-0046 2.638 µM -0.184147145440354 0.465446295689395 no 1814 0.426949011058064 2785 2802135 YIL048W NEO1
SGTC_1579 chlormadinone acetate 49.4 µM -0.184863402277749 0.465159251343445 no 1815 0.426668088464908 2900 45114258 A steroidal progestin.
SGTC_1200 1643-0193 18.4 µM -0.185454945165636 0.464922200543784 no 1816 0.426436107880401 2723 5403974
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.185869636109154 0.464756027584676 no 1817 0.426273497059326 2714 91467 include heat shock
SGTC_1279 0874-0590 65.2 µM -0.187386379760038 0.464148297939745 no 1818 0.425678850418348 2799 3523074
SGTC_59 0330-0160 1.33 µM -0.187968949507621 0.463914895740847 no 1819 0.425450495993514 2748 4293482
SGTC_219 mitoxanthrone 164.414 µM -0.189929182606528 0.463129634711436 no 1820 0.424682312129478 2813 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3053 9095903 49.47 µM -0.190048575626617 0.463081810986332 no 1821 0.424635533132477 2751 17174018
SGTC_2075 5212009 200 µM -0.192281148619692 0.462187636982851 no 1822 0.423760992049364 2858 780898
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.192915311317899 0.46193368136916 no 1823 0.423512646789499 2757 65057 A dermal irritant. YDR527W RBA50
SGTC_2925 9010536 32.5 µM -0.193513017622609 0.461694339219232 no 1824 0.423278606073586 2824 2994177
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.194860944690731 0.461154633935926 no 1825 0.422750904834572 2899 5393153
SGTC_2054 5233173 129 µM -0.195214720871983 0.461012995001793 no 1826 0.422612427586193 2909 6889
SGTC_728 3030-5151 22.5 µM -0.19578450472265 0.46078488496887 no 1827 0.422389419399138 2744 3125388
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.19653356285365 0.460485023044003 no 1828 0.422096282757789 2784 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1893 st059353 36.1 µM -0.196673292972441 0.460429088955911 no 1829 0.422041605500499 2803 3112488
SGTC_138 0850-0259 40.9225 µM -0.198327588910921 0.459766932664999 no 1830 0.421394383778895 2818 6813004
SGTC_325 2810-4341 181 µM -0.198418652456614 0.459730486364184 no 1831 0.421358762503383 2871 774970
SGTC_2226 7298446 200 µM -0.198590393697901 0.459661751405392 no 1832 0.421291584331224 2849 3283010
SGTC_3020 9089140 49.47 µM -0.199756057871009 0.459195256645957 no 1833 0.420835684674291 2838 17217859
SGTC_1126 isoteolin 1.0172 µM -0.199854187549324 0.459155988043855 no 1834 0.420797310285637 2769 133323
SGTC_542 3381-0244 89.3 µM -0.20065372160447 0.458836052988874 no 1835 0.420484674232338 2943 1112843
SGTC_3354 9151612 71.43 µM -0.201029338504273 0.458685758372604 no 1836 0.420337816759849 2889 27261949
SGTC_1718 roemerine 11.9335 µM -0.20105205851647 0.458676667662226 no 1837 0.420328934118907 2886 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3339 9145883 14.936 µM -0.201120615345531 0.458649236897864 no 1838 0.420302131311613 2908 2030670
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.202059271189509 0.458273684438079 no 1839 0.419935193978999 2959 688798
SGTC_212 3807-4682 38.772 µM -0.203859580621788 0.457553492320287 no 1840 0.419231615863364 2841 3125501 YBL034C STU1
SGTC_2598 perillyl alcohol 100 µM -0.205063153194009 0.457072095179738 no 1841 0.418761392068783 2930 10819 An apoptosis inducer.
SGTC_3123 9126162 49.47 µM -0.205901950948489 0.456736635503417 no 1842 0.418433750733179 2751 25239884
SGTC_694 1315-0438 43.2 µM -0.206437378898159 0.456522518361837 no 1843 0.418224637723278 2822 6793154
SGTC_754 3474-0146 171 µM -0.2074844148139 0.456103846203298 no 1844 0.417815781512877 2752 24762078
SGTC_2810 7959871 45.46 µM -0.209940215768492 0.455122051375521 no 1845 0.41685716697475 2883 2974535
SGTC_2301 7769476 200 µM -0.21015300219406 0.455036995158433 no 1846 0.416774129613519 2861 977820
SGTC_1980 st071811 45.7 µM -0.211039244028899 0.454682763675805 no 1847 0.41642832430082 2931 4974850
SGTC_63 0099-0242 26.702 µM -0.211654262256997 0.454436961622575 no 1848 0.416188386522373 2917 3898502 YLR359W ADE13
SGTC_2589 lobaric acid 100 µM -0.21354708636228 0.453680573519676 no 1849 0.415450133193839 2813 73157 A novel microtubule depolymerizer.
SGTC_2681 menadione 3.18 µM -0.213634535777939 0.453645632051649 no 1850 0.415416032713559 2840 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.214087448515061 0.453464671056249 no 1851 0.415239431763072 2773 23665772 A membrane-active detergent.
SGTC_1259 0671-0132 43 µM -0.214292918984034 0.453382578645038 no 1852 0.415159319810143 2815 X1259
SGTC_1494 4358-1428 177 µM -0.215591630001358 0.452863745838545 no 1853 0.414653040336883 2917 1564571
SGTC_2937 9044753 11.33 µM -0.216578247309369 0.452469647662955 no 1854 0.414268519757676 2771 6465530 YGL099W LSG1
SGTC_2179 6298986 200 µM -0.216840854147314 0.452364758861084 no 1855 0.414166186169392 2920 738374
SGTC_508 roscovitine 141 µM -0.217251802613953 0.452200627035899 no 1856 0.414006057972165 2790 160355 A CDKinase inhibitor.
SGTC_251 melphalan 456.522 µM -0.219390520971097 0.451346560595586 no 1857 0.413172926674059 2862 460612 A DNA alkylator.
SGTC_1332 1480-0653 17.5 µM -0.220588365129316 0.450868316862115 no 1858 0.412706480599581 2868 5749438
SGTC_3122 9126309 49.47 µM -0.220665365083943 0.450837576776155 no 1859 0.412676500668544 2794 17591206
SGTC_1569 carminic acid 40.6 µM -0.221295565088019 0.450585998086838 no 1860 0.412431151468056 2919 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3080 9117754 49.47 µM -0.221953423718061 0.450323399128783 no 1861 0.412175070723884 3007 9550191
SGTC_486 niguldipine 82 µM -0.222039809977757 0.450288917737634 no 1862 0.412141446429615 2784 1236 A calcium channel blocker.
SGTC_2944 9067346 25.62 µM -0.222054412830851 0.450283088992543 no 1863 0.412135762596019 2958 6473075
SGTC_2255 7941087 197.44 µM -0.2223693726751 0.450157375031699 no 1864 0.412013176016448 2950 935561
SGTC_1702 st027038 51 µM -0.222544432360208 0.450087503376659 no 1865 0.411945044159363 2847 5521182
SGTC_2817 7995342 71.43 µM -0.22286450136942 0.449959758083261 no 1866 0.411820482674379 2766 18879975
SGTC_2522 biochanin a 4.94 µM -0.223885323879196 0.449552364178555 no 1867 0.411423267866075 2922 5280373 A possible chelator.
SGTC_958 1222-0007 33 µM -0.224466379984934 0.449320497715629 no 1868 0.41119721218014 2969 7312461
SGTC_835 0312-0010 67.2 µM -0.224614045747372 0.449261575458053 no 1869 0.411139768575925 2790 1626196
SGTC_166 k072-0058 166.424 µM -0.225044497507086 0.449089821047417 no 1870 0.410972328987523 2850 5846229
SGTC_2199 6590217 200 µM -0.225193394171025 0.449030412058983 no 1871 0.410914414085262 2863 703109
SGTC_303 1348-1668 34.2 µM -0.225831347193954 0.448775885099684 no 1872 0.410666297637126 2830 5380509
SGTC_2836 9010338 19.48 µM -0.226263243216624 0.44860358158014 no 1873 0.410498342376088 2822 2994051
SGTC_629 3448-6466 76.7 µM -0.226328184870327 0.448577674155334 no 1874 0.410473089354309 2844 573744
SGTC_2740 felodipine 17.08 µM -0.226930929107398 0.448337229545221 no 1875 0.410238725713343 2908 3333 L-type calcium channel blocker
SGTC_921 1561-0023 372 µM -0.227358957195222 0.448166493604666 no 1876 0.410072316005657 2777 24050882
SGTC_3131 9127911 49.47 µM -0.228093147483961 0.447873655131291 no 1877 0.409786913606295 3052 45595681
SGTC_368 fentichlor 4.58 µM -0.228696093531019 0.447633185853812 no 1878 0.409552565622808 2886 7329 A pesticide.
SGTC_1751 st044839 27.194 µM -0.228964144529132 0.447526286891421 no 1879 0.409448392192835 2770 5291326
SGTC_2043 5101342 149 µM -0.229632070164697 0.447259934186823 no 1880 0.409188842161889 2840 678451
SGTC_2236 dapsone 200 µM -0.230680475831598 0.446841903193074 no 1881 0.408781521254444 2838 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_871 0574-0004 149 µM -0.230755448601549 0.446812011543253 no 1882 0.408752397007434 2809 9551173
SGTC_1347 1493-0251 600 nM -0.231253843320736 0.446613309215202 no 1883 0.408558801250942 2939 3986378
SGTC_568 1193-0097 7.48 µM -0.2312732238443 0.446605582768208 no 1884 0.408551273557512 2916 3646150
SGTC_2221 6807166 181.081 µM -0.231693923473578 0.446437867150953 no 1885 0.408387875671184 2879 674925
SGTC_431 k089-0097 107 µM -0.232530150048406 0.446104526530492 no 1886 0.408063136263135 2934 5499420
SGTC_1885 st057546 99.9 µM -0.234385070221336 0.445365245696306 no 1887 0.407343024055335 2966 702008
SGTC_2993 9054257 71.4286 µM -0.237492990003653 0.444127007261416 no 1888 0.406137178416385 2803 6470217 YGL055W OLE1
SGTC_2992 9074591 71.4286 µM -0.237723822730688 0.444035061896493 no 1889 0.406047652700696 2937 17741321
SGTC_2224 6650123 117.647 µM -0.238075179666014 0.443895115074193 no 1890 0.40591139254171 2829 2908370
SGTC_417 st075190 100 µM -0.238524387034565 0.443716204239069 no 1891 0.405737201490565 2965 222757
SGTC_2555 cholic acid 100 µM -0.23883339626027 0.44359313834138 no 1892 0.405617386502191 2989 6708657 Influences liver metabolism.
SGTC_1933 st074711 15.9 µM -0.239277182008887 0.443416405915831 no 1893 0.405445328844249 2783 17250958
SGTC_2238 6671620 73.2395 µM -0.240605482640932 0.442887493294766 no 1894 0.404930450236381 2762 729941
SGTC_2946 9065502 71.43 µM -0.242700975506254 0.442053301619943 no 1895 0.404118525850042 2847 16489101
SGTC_2682 pyrogallin 40.03 µM -0.242831741453176 0.442001253674347 no 1896 0.40406787263146 2873 822798 An ATP competetive kinase inhibitor.
SGTC_1136 pergolide 1.05886 µM -0.243848166686797 0.441596726552546 no 1897 0.403674207220687 2844 47811 A dopamine receptor agonist.
SGTC_1119 parthenolide 318.541 nM -0.244472998491176 0.441348079920809 no 1898 0.403432255850341 3044 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_43 0570-0105 72.5 µM -0.244815184281851 0.441211919714215 no 1899 0.403299768134085 2848 1114046 YDL195W SEC31
SGTC_1150 3909-7983 10.9 µM -0.245059476726378 0.441114716801867 no 1900 0.403205189616136 2867 23965914
SGTC_1214 0358-0031 63.7 µM -0.245503840664015 0.440937915401838 no 1901 0.403033167367831 3111 4301366
SGTC_2063 5246145 200 µM -0.246221610158665 0.440652357583415 no 1902 0.402755343960571 2964 711240
SGTC_2561 acetosyringone 100 µM -0.246511498862161 0.440537036839011 no 1903 0.402643152117316 2809 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1247 0448-0043 5.84 µM -0.247410871368696 0.440179289229178 no 1904 0.402295130767873 2971 3089013 YGL099W LSG1
SGTC_3093 9117344 49.47 µM -0.248496952985626 0.43974733857665 no 1905 0.401874963663053 2990 24824913
SGTC_2278 7948257 134.34 µM -0.249465070076607 0.439362364591098 no 1906 0.401500528484564 3002 1247028
SGTC_2439 5492030 7.2 µM -0.249746516337806 0.439250457580671 no 1907 0.401391691472013 2971 5722370
SGTC_1064 honokiol 6.76 µM -0.249817326026244 0.439222303412012 no 1908 0.401364310131008 2925 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_941 3237-0776 460 µM -0.249834166836736 0.439215607494755 no 1909 0.401357798042946 3024 760008
SGTC_58 0957-0393 9 µM -0.249839053639035 0.439213664502223 no 1910 0.401355908395143 2900 6997992
SGTC_585 0kpi-0023 191 µM -0.251145306005741 0.438694351240988 no 1911 0.40085088449174 2987 64601
SGTC_8 0354-0001 70 µM -0.251660512551871 0.438489554864419 no 1912 0.400651740602341 2858 4993152
SGTC_291 SEC14.278 35.5 µM -0.252278789772947 0.438243809285304 no 1913 0.400412790671883 2956 1068044
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.252527694029971 0.438144884457393 no 1914 0.40031660541619 2913 688761
SGTC_2427 5545055 42.75 µM -0.25325399583428 0.437856244251126 no 1915 0.400035971734961 2873 5372858
SGTC_2549 cedrol 20.94 µM -0.255310461489784 0.437039162349461 no 1916 0.399241660265581 3035 6708665 A sedative which affects the nervous system.
SGTC_3314 9135860 59.4275 µM -0.258415840719294 0.435805832464463 no 1917 0.39804299627506 3010 25252478
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.25854446029871 0.435754763393336 no 1918 0.397993370293281 2963 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3153 9100258 49.47 µM -0.260131688060625 0.435124634818565 no 1919 0.397381097772967 2889 25236848
SGTC_1116 jasmonic acid 1.58368 µM -0.260166496464236 0.435110817740866 no 1920 0.397367673271133 3023 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3019 9081971 49.47 µM -0.263044690078862 0.433968604250346 no 1921 0.396258066955008 3033 16451803
SGTC_497 capsazepine 133 µM -0.26426862329585 0.43348305180802 no 1922 0.395786468028347 2874 2733484 A calcium channel blocker.
SGTC_833 3852-0053 558 µM -0.264545130067611 0.433373371348296 no 1923 0.395679947121183 3037 3123681
SGTC_2036 5160441 105 µM -0.264628150117854 0.433340441230964 no 1924 0.395647966166186 2917 134534 YIL048W NEO1
SGTC_1033 k072-0102 21.3 µM -0.265402687312744 0.433033241381467 no 1925 0.395349633098082 3059 5965931
SGTC_2841 9004761 38.96 µM -0.266307333853311 0.432674488317115 no 1926 0.395001262692951 2897 2991039
SGTC_810 3825-7150 143 µM -0.266670414518468 0.432530518055046 no 1927 0.394861467516038 3061 22330411 YGL099W LSG1
SGTC_2910 7948405 25.97 µM -0.266677838925717 0.432527574191455 no 1928 0.394858609073893 3042 2971328
SGTC_3342 9147791 14.508 µM -0.267346716469384 0.432262371875133 no 1929 0.394601110374089 2871 1838168
SGTC_2955 9076254 12.21 µM -0.268944333288284 0.431629058742549 no 1930 0.393986260170654 3002 16459619
SGTC_2706 st078239 82.5 µM -0.271491819289266 0.430619570953996 no 1931 0.393006395391546 2880 15434492
SGTC_699 0375-0592 111 µM -0.27165795206978 0.430553753480368 no 1932 0.392942517561235 2983 762578
SGTC_3164 9100705 49.47 µM -0.271751137168474 0.430516836819622 no 1933 0.392906689278203 3039 17174235
SGTC_1767 st044992 70.3 µM -0.272063875984757 0.43039294513369 no 1934 0.392786452493265 2935 9600693
SGTC_3323 9138564 53.9225 µM -0.272259402012373 0.430315490850563 no 1935 0.392711284990716 3050 43912313 YNL103W MET4
SGTC_600 1495-0418 41.6 µM -0.27331847867143 0.429896002458352 no 1936 0.392304205998089 2888 5377768
SGTC_3075 9116269 49.47 µM -0.274043681999126 0.429608803162038 no 1937 0.392025526366776 3095 17015205 YNL244C SUI1
SGTC_2194 5927483 104.545 µM -0.2743036099001 0.429505874042856 no 1938 0.391925655286328 2875 760979
SGTC_110 0850-0284 111.64 µM -0.274306908460617 0.429504567873232 no 1939 0.391924387939066 2819 3906265
SGTC_717 1532-0246 73.2 µM -0.275381453861445 0.42907910870642 no 1940 0.391511595569867 2971 9561992
SGTC_1861 st057647 17.4 µM -0.275821962222986 0.428904716105983 no 1941 0.391342407195446 3066 688668
SGTC_1834 st055981 52.8 µM -0.278377380265653 0.427893327956218 no 1942 0.390361340731557 3050 471719 YDL150W RPC53
SGTC_3176 9106582 49.47 µM -0.279417950227422 0.42748162452518 no 1943 0.389962048581934 2970 17018027
SGTC_813 k007-0158 173 µM -0.279753724782401 0.427348791529416 no 1944 0.389833228423676 2960 6523916
SGTC_929 2805-0021 398 µM -0.279840606665958 0.427314422246372 no 1945 0.389799898094269 2975 3098024
SGTC_485 niflumic acid 177 µM -0.279958905670991 0.427267625667431 no 1946 0.389754516578072 3010 4488 A COX2 inhibitor.
SGTC_1828 st055811 49 µM -0.28073923484139 0.426958969657455 no 1947 0.389455206679472 3056 5877589
SGTC_1728 st035614 33.7865 µM -0.281481872829083 0.426665263764271 no 1948 0.389170414827547 2993 15945546
SGTC_3264 9137442 49.47 µM -0.282012524093688 0.426455421395194 no 1949 0.388966953537192 3139 17015726
SGTC_2074 5212007 75.395 µM -0.282383195142665 0.42630885444071 no 1950 0.388824849612437 2983 758611
SGTC_1921 5740136 50 µM -0.283853631041391 0.42572753017503 no 1951 0.388261276241036 3109 1774243
SGTC_187 1488-2104 32.728 µM -0.284108332663084 0.42562685242965 no 1952 0.388163680718733 2968 2852859
SGTC_2506 ethyl hematommate 54.16 µM -0.284207849495929 0.425587517010982 no 1953 0.388125550185429 2968 3940691 An allergen.
SGTC_2630 antimycin a 100 µM -0.284798132011368 0.42535421483608 no 1954 0.387899401713367 2851 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_27 0485-0001 32.618 µM -0.285930899062535 0.42490657534053 no 1955 0.38746552362136 2887 2054479
SGTC_1738 st035555 74 µM -0.286485670287659 0.424687379747368 no 1956 0.387253083602211 3019 5331140
SGTC_275 trichlorophene 5.69 µM -0.286711145153655 0.424598299051376 no 1957 0.387166751558524 3011 62616
SGTC_1162 k048-0130 20.1 µM -0.286715915963797 0.424596414239475 no 1958 0.387164924923893 2918 6797406
SGTC_1115 galangin 695.678 nM -0.286920904250782 0.424515430804955 no 1959 0.387086441934487 3056 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1451 4152-0210 104 µM -0.286987135937859 0.424489265749418 no 1960 0.387061085077983 3080 659563
SGTC_1642 st009582 77.7 µM -0.28807475349524 0.424059646376544 no 1961 0.386644758808143 3057 6739311
SGTC_2651 TUB2.036 5 µM -0.288652396649996 0.423831508441347 no 1962 0.386423697300696 3043 15992207 YFL037W TUB2
SGTC_676 falcarinol 140 µM -0.289423058874575 0.423527178127205 no 1963 0.386128825638807 3106 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_946 3434-1334 87.4 µM -0.291273666788185 0.422796569751931 no 1964 0.38542101279328 3071 4047976
SGTC_2790 5423970 71.43 µM -0.291562041859471 0.422682744929944 no 1965 0.385310750584613 3104 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1913 st060213 96.1 µM -0.292986491927057 0.422120593647016 no 1966 0.38476623837445 3099 688959
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.293866096580501 0.42177354171592 no 1967 0.384430112911692 2877 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1942 st076330 65.2 µM -0.294055427708356 0.421698848212582 no 1968 0.384357774701695 3079 24208414
SGTC_851 0394-0702 453 µM -0.295357779977549 0.42118513038975 no 1969 0.38386029101907 3059 762646
SGTC_1989 st071868 50.2 µM -0.296784329395597 0.420622576499497 no 1970 0.383315585036459 3074 16414057
SGTC_3202 9113761 49.47 µM -0.297790372947704 0.420225944747927 no 1971 0.382931581337271 3083 4798415
SGTC_2566 crystal violet carbinol 226 nM -0.298092666937143 0.420106781425699 no 1972 0.382816219118421 3087 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2886 9058944 51.95 µM -0.298457505316531 0.419962973059184 no 1973 0.382677002391191 2969 4949929
SGTC_470 aa-861 153 µM -0.298735810730658 0.419853280580658 no 1974 0.38257081550655 2959 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2884 9058502 51.95 µM -0.300101339419097 0.419315155680221 no 1975 0.382049928778948 3042 6471554
SGTC_1701 st028638 40.4 µM -0.300904565253117 0.418998692411205 no 1976 0.381743634497941 3053 3490878
SGTC_2093 5331342 194.4 µM -0.302599394799365 0.418331118013704 no 1977 0.381097587869546 3086 33839
SGTC_1318 1280-3875 124 µM -0.30265701385035 0.418308426636987 no 1978 0.38107563006117 3001 373245
SGTC_635 k038-0028 24.7 µM -0.303060804250939 0.418149414641229 no 1979 0.380921761977752 2981 4035102
SGTC_3352 9151559 45.5865 µM -0.303354028208311 0.418033951912048 no 1980 0.380810038064075 3021 17159339
SGTC_2260 7964312 200 µM -0.305208476248902 0.417303890348618 no 1981 0.380103688551663 3113 231951
SGTC_51 1013-0126 23.419 µM -0.306255582720468 0.41689178981766 no 1982 0.379705027609669 3226 1627850
SGTC_707 0865-0008 204 µM -0.306388860945074 0.416839343214002 no 1983 0.379654294250202 2962 723043
SGTC_1793 st048256 72.231 µM -0.306608216432067 0.416753027382841 no 1984 0.379570799443899 2914 672022
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.307793320795978 0.416286761317184 no 1985 0.379119802132447 2903 5355888
SGTC_2021 4019055 173 µM -0.307991130583543 0.416208946720004 no 1986 0.379044540644622 3102 44827708 YER133W GLC7
SGTC_783 0848-0141 92.7 µM -0.308309953023802 0.416083534967438 no 1987 0.378923246636329 2916 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2280 7785178 200 µM -0.308793539465848 0.415893328084867 no 1988 0.378739291951201 2956 2954328
SGTC_2397 5161689 200 µM -0.308977925634275 0.415820809487072 no 1989 0.378669159292883 3149 2259942
SGTC_1299 1079-1439 3.74 µM -0.310578785729324 0.415191316134008 no 1990 0.378060428343879 2980 323161
SGTC_1414 3917-0015 5.4 µM -0.31111251297481 0.414981491155584 no 1991 0.377857544446884 3059 6618702
SGTC_119 0121-0043 24.815 µM -0.311373354370569 0.414878955011171 no 1992 0.377758403957796 2967 1092378
SGTC_197 4544-0043 41.561 µM -0.313329899851159 0.414110026883733 no 1993 0.37701501809506 2942 896523
SGTC_2532 xanthone 78.9 µM -0.313592584317018 0.414006816112079 no 1994 0.376915246247856 3061 7020 An insecticide.
SGTC_2259 7964009 200 µM -0.314628084420993 0.41360001797671 no 1995 0.376522026521138 3109 313134
SGTC_2927 9011802 47.9 µM -0.315198038830402 0.413376149862511 no 1996 0.376305647259147 3064 43912568
SGTC_1956 st077085 54 µM -0.315465371124921 0.413271156114043 no 1997 0.376204169783871 2987 24208685
SGTC_989 1501-0895 10.3 µM -0.317936232895751 0.412301029008348 no 1998 0.375266653804112 3073 2830112
SGTC_2031 5180455 200 µM -0.318077798108077 0.41224546284667 no 1999 0.375212962142592 2964 29949
SGTC_3113 9123498 49.47 µM -0.318266346275255 0.412171458004417 no 2000 0.375141454936098 3002 8897275
SGTC_1139 k015-0024 46.9 µM -0.318917105754484 0.41191605999672 no 2001 0.374894686296127 3103 2766652
SGTC_2213 7173844 200 µM -0.318960480940254 0.411899038233507 no 2002 0.374878240201984 2997 892728
SGTC_286 k060-0067 22.9 µM -0.320046006109999 0.411473098681513 no 2003 0.374466727684965 2997 5985051
SGTC_2699 st077704 54.6 µM -0.320928895106139 0.411126746630832 no 2004 0.374132138048498 3036 645852
SGTC_185 k048-0037 25.491 µM -0.325370080917999 0.409385551925523 no 2005 0.372450498312889 3115 6827589
SGTC_2099 5377090 177.372 µM -0.325815604046254 0.409210979799834 no 2006 0.37228193603711 3064 2243829
SGTC_616 4092-0450 108 µM -0.325830738661086 0.409205049824641 no 2007 0.372276210332656 3028 787165
SGTC_2003 4023581 200 µM -0.325874150928567 0.409188040344892 no 2008 0.372259786826335 3121 16641307
SGTC_181 1447-1644 8.07 µM -0.326249716269393 0.409040896198528 no 2009 0.372117714575695 3076 534600
SGTC_2876 9059903 25.97 µM -0.326335232871801 0.409007393120489 no 2010 0.372085367015007 2949 6916095
SGTC_332 4112-0506 40.9 µM -0.327394252954716 0.408592553029691 no 2011 0.371684856326349 2976 2790355
SGTC_316 k060-0003 58.6 µM -0.328401357727099 0.408198144221576 no 2012 0.371304108274524 3113 6152314
SGTC_1141 3253-0389 52.6 µM -0.329673378276089 0.407700120344122 no 2013 0.370823385615887 3087 5402031
SGTC_1465 k213-0056 144 µM -0.330805181273855 0.407257120046221 no 2014 0.37039582347284 2965 24048857 YMR208W ERG12
SGTC_3084 9116877 49.47 µM -0.332897489518267 0.40643847997897 no 2015 0.369605832270776 3064 27241325
SGTC_1760 st045453 10.4495 µM -0.332959008775127 0.4064144160193 no 2016 0.369582612801897 3123 3323419 YIL048W NEO1
SGTC_962 1254-0300 21.5 µM -0.333307829989209 0.406277977305468 no 2017 0.369450964756995 2947 7340576
SGTC_3355 9151058 44.0485 µM -0.333387235070584 0.406246920212914 no 2018 0.369420998752932 3043 17015728
SGTC_3156 9099931 49.47 µM -0.334112536505175 0.405963266022862 no 2019 0.369147320188705 2958 18111053
SGTC_681 1642-0006 26.6 µM -0.335084732310114 0.405583132702788 no 2020 0.368780584813923 3096 4446530
SGTC_2249 haloperidol 116.36 µM -0.335811590297475 0.40529898581258 no 2021 0.368506474719372 2971 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_32 0928-0142 34.1 µM -0.336169265802526 0.405159179861998 no 2022 0.368371613958789 3089 2244242
SGTC_3015 9080845 49.47 µM -0.336799607894003 0.404912825179318 no 2023 0.368133984339898 3127 5296973
SGTC_2710 st078562 53.7235 µM -0.336904142344162 0.404871973938043 no 2024 0.368094581276788 2952 17250908
SGTC_2866 9034245 58.44 µM -0.338221886702057 0.404357098848772 no 2025 0.367597991770167 3064 6462273
SGTC_2702 st077768 96.8 µM -0.338826987977697 0.404120726344158 no 2026 0.36737003456887 3080 6484119
SGTC_965 1291-5240 308 µM -0.339818693722845 0.403733409114802 no 2027 0.366996534618842 3131 2834598
SGTC_891 0929-0073 133 µM -0.340534980759456 0.403453717160349 no 2028 0.366726842155989 3127 5603632
SGTC_1407 3909-7909 12.3 µM -0.340966599106607 0.403285204952305 no 2029 0.36656436333651 3016 4411780
SGTC_2026 5148700 152 µM -0.341510941554229 0.403072708667802 no 2030 0.366359484645091 2982 79838
SGTC_745 0469-0705 296 µM -0.342317222848764 0.402758011290511 no 2031 0.366056087849451 3231 3486736
SGTC_1133 3473-0247 50 µM -0.34242358847367 0.402716500722249 no 2032 0.366016069616679 3050 711311
SGTC_3218 9131285 49.47 µM -0.343384292832474 0.402341623092846 no 2033 0.365654687244993 3186 17156417
SGTC_2747 doxorubicin 7.63 µM -0.344085271678755 0.402068149918815 no 2034 0.365391079453933 3039 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1710 st031758 61.5 µM -0.344891345969432 0.4017537350754 no 2035 0.365088028409199 3180 5394341
SGTC_1864 st057645 30.4 µM -0.34521300124495 0.401628288950515 no 2036 0.364967122653826 3084 688666
SGTC_1045 1348-1485 165 µM -0.345586495676075 0.401482638182733 no 2037 0.364826748124084 3011 6810614
SGTC_1288 0973-0013 65.5 µM -0.345797105666541 0.40140051312062 no 2038 0.364747600236965 3123 4315430
SGTC_2829 7992743 58.44 µM -0.345899097644809 0.401360744029347 no 2039 0.364709273406799 3164 16462845
SGTC_1435 4092-0789 56.7 µM -0.345955734155924 0.401338660551632 no 2040 0.364687990964489 3114 2248285
SGTC_2536 dehydroabietamide 32.04 µM -0.347055358433895 0.400909962073082 no 2041 0.364274865138234 3155 3983547
SGTC_643 k048-0106 28.4 µM -0.347453086465768 0.400754933550588 no 2042 0.364125478602228 3103 6763920
SGTC_2571 chrysanthemic acid 100 µM -0.34847232613688 0.400357720358402 no 2043 0.363742746751972 3043 2743 An insecticide.
SGTC_3049 9092223 49.47 µM -0.349010081917483 0.400148190253748 no 2044 0.363540870325469 3112 8623917
SGTC_1467 k284-1082 293 µM -0.349709371282406 0.399875763514843 no 2045 0.363278409990419 3112 3334705
SGTC_3124 9127567 49.47 µM -0.349770085897142 0.399852112821704 no 2046 0.363255625342625 3206 17592030
SGTC_2206 7254556 146.969 µM -0.349842284387492 0.399823989192589 no 2047 0.363228531718734 3064 4398905
SGTC_355 1311-2252 105 µM -0.350245664588475 0.399666869224458 no 2048 0.363077169522869 3033 5338538
SGTC_3315 9136395 68.55 µM -0.350385933337305 0.399612237176997 no 2049 0.363024540848908 3230 16876844
SGTC_1218 1348-1416 30.7 µM -0.350558528062983 0.399545017464815 no 2050 0.3629597870549 3003 6787668
SGTC_1775 st081588 35.1725 µM -0.350767724662049 0.399463546573126 no 2051 0.362881306284925 3041 1426443 YGL099W LSG1
SGTC_575 k072-0246 11.9 µM -0.351543812265799 0.399161340213795 no 2052 0.362590204884026 3039 6796779
SGTC_1345 1488-0192 31.4 µM -0.353041548185187 0.398578296979062 no 2053 0.362028646257995 3176 658348
SGTC_1983 st071813 46.9 µM -0.354101806836057 0.398165692956952 no 2054 0.36163129402351 3090 11838595
SGTC_2602 kawain 100 µM -0.355548052800403 0.397603064013131 no 2055 0.361089526214341 3091 5369129
SGTC_2922 7999257 32.47 µM -0.356205735965942 0.397347277770414 no 2056 0.360843248314348 3062 2988377
SGTC_1973 st070275 50.2 µM -0.358676626159503 0.396386694030184 no 2057 0.35991850804065 3089 17118334
SGTC_590 k048-0076 22.4 µM -0.35901351367374 0.396255774143886 no 2058 0.359792489926519 3152 6832814
SGTC_306 1672-3436 11.6 µM -0.359083289202352 0.396228659717321 no 2059 0.359766391188936 3139 6797378
SGTC_2417 cerulenin 830 nM -0.359500679679493 0.396066474321402 no 2060 0.359610284718834 3154 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2873 9040596 71.43 µM -0.359549144535834 0.39604764349982 no 2061 0.359592160097488 3150 6463863
SGTC_1636 st007707 68.9 µM -0.360776619832412 0.395570793982329 no 2062 0.359133221009298 3246 403051
SGTC_3070 9117005 49.47 µM -0.362122969028824 0.395047944081263 no 2063 0.358630070004474 3121 8779016
SGTC_515 4092-1064 102 µM -0.362149975123122 0.39503745829069 no 2064 0.358619979926019 3251 717353
SGTC_1351 1496-0003 46.5 µM -0.362556838274411 0.394879492714583 no 2065 0.358467978735008 3173 3891978
SGTC_445 e6 berbamine 66 µM -0.362779753334269 0.394792952742954 no 2066 0.358384708753347 3128 6610268 A calcium/calmodulin antagonist.
SGTC_703 3875-0075 71.8 µM -0.363915655114661 0.394352054230501 no 2067 0.357960496987768 3048 2850814
SGTC_741 4582-0002 126 µM -0.364046987967803 0.394301086304421 no 2068 0.357911460962904 3031 2912688
SGTC_878 0828-0289 13.7 µM -0.368972184133704 0.392391019765191 no 2069 0.356074229023818 3067 745350 YLR208W SEC13
SGTC_1488 4013-0813 75.9 µM -0.368975908018272 0.392389576559638 no 2070 0.356072841170878 3063 2910057
SGTC_2273 7815444 169.05 µM -0.371618017977851 0.391365991003121 no 2071 0.355088635983125 3215 2824616
SGTC_2782 7736369 71.43 µM -0.373128508735596 0.390781145799384 no 2072 0.354526400740545 3084 2950836 YOL077C BRX1
SGTC_3154 9100113 49.47 µM -0.373924018422925 0.390473232502819 no 2073 0.354230423211908 3070 25237525
SGTC_164 4100-3994 89.624 µM -0.374746090764894 0.390155109913224 no 2074 0.353924655263883 3185 4615967
SGTC_1187 1391-0724 117 µM -0.376794298653359 0.389362822131225 no 2075 0.353163239013787 3115 6997986
SGTC_3115 9123671 49.47 µM -0.376801891649658 0.389359885861594 no 2076 0.353160417427197 3183 3286988
SGTC_54 0159-0055 9 µM -0.376843544017704 0.389343778685289 no 2077 0.353144939390849 3296 3319099
SGTC_217 ketoconazole 989 nM -0.377153863502513 0.389223782595229 no 2078 0.353029632197322 3142 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1998 st075797 76.8 µM -0.37823966609755 0.388804001534543 no 2079 0.352626280567111 3188 24208315
SGTC_1679 SEC14.276 6.7 µM -0.379311102113603 0.388389901947449 no 2080 0.352228428148589 3182 1005053 YMR079W SEC14
SGTC_448 monastrol 171 µM -0.37950540793634 0.388314818211362 no 2081 0.352156294583069 3118 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_669 0108-0021 26.2 µM -0.384220102659404 0.386494249496332 no 2082 0.350407659970853 3387 17201
SGTC_3105 9121040 49.47 µM -0.384322508951979 0.386454733086895 no 2083 0.35036971346566 3129 41448907
SGTC_2804 7954240 19.48 µM -0.385881290545332 0.385853378036285 no 2084 0.349792293751777 3201 828705
SGTC_3028 9087778 49.47 µM -0.385949672107216 0.385827003701774 no 2085 0.349766971100249 3083 17217395
SGTC_484 loperamide 105 µM -0.386704776566271 0.385535799820547 no 2086 0.349487389785255 3101 3955 An opioid-receptor agonist.
SGTC_1425 4048-4433 7.33 µM -0.387287419151653 0.385311149452907 no 2087 0.34927171915108 3170 23734946
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.38961043407162 0.384415844382515 no 2088 0.348412317710978 3122 688788
SGTC_2568 diosmetin 100 µM -0.390504884867809 0.384071281276232 no 2089 0.348081621935952 3251 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_656 4090-1979 187 µM -0.391260160125524 0.383780403125209 no 2090 0.347802471973842 3221 22330961
SGTC_866 0495-0101 262 µM -0.391316996084665 0.383758516615007 no 2091 0.347781468721485 3077 635694
SGTC_1255 0566-0045 221 µM -0.391766614289702 0.383585389769661 no 2092 0.347615332550961 3239 2788469
SGTC_230 MPP+ 141.667 µM -0.39195782927748 0.383511768903152 no 2093 0.347544686525516 3141 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_936 3005-4620 401 µM -0.392521978605441 0.383294586793582 no 2094 0.347336287555652 3280 777207
SGTC_477 mead ethanolamide 10 µM -0.392538720651615 0.383288142122245 no 2095 0.347330103682992 3122 16061185
SGTC_488 nitrendipine 139 µM -0.392953210586476 0.383128598963899 no 2096 0.34717701988731 3131 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_748 act1.228 77.9 µM -0.393070003982439 0.38308364707852 no 2097 0.347133889019469 3083 4421505 YNR035C ARC35
SGTC_1269 0831-0796 3.05 µM -0.393739197560033 0.382826115685824 no 2098 0.3468867993678 3223 927758
SGTC_1480 1070-0044 41.2 µM -0.394823941402755 0.382408774657797 no 2099 0.346486412361219 3172 3124987
SGTC_983 1491-0821 12.2 µM -0.395440584041123 0.382171590298571 no 2100 0.346258881390367 3210 46495113
SGTC_893 0958-0369 48.9 µM -0.396200104772893 0.38187951032472 no 2101 0.345978707011142 3208 6819948
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.396733827679419 0.381674302978227 no 2102 0.345781876062466 3249 16725076
SGTC_1753 st043925 64 µM -0.397998071948159 0.381188355394641 no 2103 0.345315803484689 3197 670181
SGTC_636 0kpi-0074 126 µM -0.39977026421847 0.380507479231456 no 2104 0.344662867104899 3160 616434
SGTC_1098 clofazimine 15.1 µM -0.40003444068924 0.380406014285027 no 2105 0.344565574999585 3222 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3298 9116858 71.43 µM -0.400518623825028 0.380220070502609 no 2106 0.344387284538832 3236 2506942
SGTC_612 0302-0167 22.4 µM -0.402092996572076 0.37961564612786 no 2107 0.343807793372192 3167 235821
SGTC_3092 9117248 49.47 µM -0.40414156666493 0.37882961096368 no 2108 0.343054310066561 3162 17141857
SGTC_2591 skatole 100 µM -0.404871658153412 0.378549596179029 no 2109 0.342785926144217 3222 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3341 9147222 25.867 µM -0.405958987610422 0.378132686765 no 2110 0.342386367494137 3235 1939759
SGTC_1508 1080-0625 72.9 µM -0.406201779482412 0.378039613623598 no 2111 0.342297173348259 3106 767111
SGTC_3258 9138477 49.47 µM -0.408341611773219 0.377219625463901 no 2112 0.341511446723102 3157 4970355
SGTC_1608 st001473 40.5 µM -0.411306663772973 0.376084326545658 no 2113 0.340423841952405 3127 7292267
SGTC_3013 9080133 71.4286 µM -0.411371924097576 0.376059350812777 no 2114 0.340399918823575 3344 17050193
SGTC_383 2324-0395 7.37 µM -0.411495076332483 0.376012220721843 no 2115 0.340354775428713 3244 3146421
SGTC_3322 9139058 2.11 µM -0.411600481276655 0.375971883948944 no 2116 0.340316139400175 3294 4908926 YPR165W RHO1
SGTC_2906 7926292 26.41 µM -0.411637171669343 0.375957843445069 no 2117 0.340302690983514 3241 2966319
SGTC_2748 diazoxide 86.69 µM -0.412070612612884 0.375791988772136 no 2118 0.340143833860434 3164 3019 A potassium channel activatior.
SGTC_1262 0737-0114 49.6 µM -0.412814588800269 0.375507362373558 no 2119 0.339871230996191 3292 765919
SGTC_2020 4017018 200 µM -0.413134929555522 0.375384828990574 no 2120 0.339753879616793 3234 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1520 flindersine 88 µM -0.413559080230202 0.375222606670826 no 2121 0.339598523137253 3354 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_617 3770-0098 35 µM -0.415272912236373 0.3745673527871 no 2122 0.338971064257816 3161 5962639
SGTC_2594 a-mangostin 100 µM -0.416065681149406 0.374264373723282 no 2123 0.338680970917701 3266 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_856 0433-0016 11.3 µM -0.416508297596627 0.374095249089844 no 2124 0.338519048451224 3221 3911780
SGTC_514 4466-0038 2.65 nM -0.417235246305183 0.373817533120302 no 2125 0.338253173435056 3133 5722064
SGTC_556 4058-0063 51.5 µM -0.417607964430949 0.373675169130554 no 2126 0.338116886360594 3182 6615692
SGTC_462 ag-879 158 µM -0.419444132091033 0.372974075641468 no 2127 0.337445788338752 3225 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_447 ml7 120 µM -0.420973725529736 0.372390360559222 no 2128 0.33688713403247 3233 4216 Selective myosin light chain kinase inhibitor.
SGTC_977 1348-1378 135 µM -0.422383026905768 0.371852809993683 no 2129 0.336372732344239 3106 X977
SGTC_1431 4049-0260 9.09 µM -0.422834035088407 0.371680834400329 no 2130 0.336208176834705 3168 3854841
SGTC_2346 9031566 143.75 µM -0.422883434713823 0.37166199920227 no 2131 0.336190154720814 3192 4771086
SGTC_2833 9001315 45.46 µM -0.424722251205048 0.370961110116097 no 2132 0.335519580521857 3088 2989378
SGTC_2353 9059630 146.67 µM -0.424757939334287 0.370947511341716 no 2133 0.335506571052405 3235 4779114
SGTC_801 0866-0028 10.1 µM -0.425708529773381 0.370585353212693 no 2134 0.335160122929339 3110 6849771
SGTC_3117 9124945 49.47 µM -0.426350238487815 0.370340938352935 no 2135 0.334926327752458 3097 17592065
SGTC_1693 xanthone 101.9 µM -0.426440901343235 0.370306410782563 no 2136 0.334893301505212 3171 7020 An insecticide.
SGTC_3145 9085516 49.47 µM -0.42795752484656 0.369728982916968 no 2137 0.3343410223866 3233 25236195
SGTC_1691 st019933 84.6 µM -0.428873462380069 0.36938039785223 no 2138 0.334007656819093 3238 6176082
SGTC_1138 3761-0006 1.03 µM -0.429562431882274 0.369118262407396 no 2139 0.333756985039153 3245 12061087
SGTC_155 k072-0202 43.6 µM -0.431911522265868 0.368224951152013 no 2140 0.332902860025389 3237 5857737
SGTC_307 1501-1223 22.3 µM -0.43226318915717 0.368091280545738 no 2141 0.332775069025363 3234 2830329
SGTC_939 1165-0479 45.3 µM -0.433718785379758 0.367538170064636 no 2142 0.332246331748086 3276 1377347
SGTC_2801 7907800 81.82 µM -0.435054117031605 0.36703100030834 no 2143 0.331761573368514 3236 6620925
SGTC_446 go6976 132 µM -0.436133138431656 0.366621348658491 no 2144 0.331370067571888 3270 3501 A protein kinase C inhibitor.
SGTC_2170 morpholine 200 µM -0.43685309328575 0.366348101464911 no 2145 0.331108945805448 3277 121171 Reacts with secondary amines.
SGTC_342 k048-0088 23.3 µM -0.437660177124443 0.366041866420749 no 2146 0.330816320691697 3148 6820570
SGTC_1305 1181-0477 144 µM -0.439262497307879 0.365434144660865 no 2147 0.330235672424905 3297 6252086
SGTC_988 1497-1057 103 µM -0.440286641715263 0.365045887948702 no 2148 0.329864757243826 3319 3533044
SGTC_1385 3091-4834 14.1 µM -0.440637042434757 0.364913081552244 no 2149 0.329737890717762 3261 4072814
SGTC_782 0083-0095 30.5 µM -0.440867640481101 0.364825690755929 no 2150 0.329654410784104 3146 3591729 An indicator and reagent.
SGTC_544 k015-0020 52.4 µM -0.44160629341713 0.364545807368293 no 2151 0.329387064546438 3222 3008304
SGTC_244 nsc-207895 1.295 µM -0.441751925204078 0.364490634463446 no 2152 0.329334365219854 3159 42640
SGTC_2808 7946468 45.46 µM -0.441803205475588 0.364471207494325 no 2153 0.329315809392824 3221 2970879
SGTC_2620 irigenin 100 µM -0.44206382980295 0.36437247820428 no 2154 0.329221508669582 3338 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2328 6201408 200 µM -0.44248821162549 0.364211733819102 no 2155 0.329067979435894 3273 2890418
SGTC_918 glabranin 770.725 nM -0.443300727953014 0.363904041212718 no 2156 0.328774114665048 3217 124049 Also referred to as licorice root.
SGTC_574 1315-0397 40 µM -0.443593694063372 0.36379311909754 no 2157 0.328668182844217 3213 6794277
SGTC_2608 thymoquinone 42.66 µM -0.444929545636404 0.363287487032511 no 2158 0.328185335057035 3270 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3228 9131799 49.47 µM -0.445357555757046 0.363125531608299 no 2159 0.328030690096557 3236 17015818
SGTC_2854 9024559 71.43 µM -0.445461995678706 0.363086016134806 no 2160 0.327992959229057 3258 3163529
SGTC_1184 1269-1718 139 µM -0.445665400104612 0.363009061028588 no 2161 0.327919480629307 3320 5403821
SGTC_780 0109-0199 192 µM -0.447361627164884 0.362367533837802 no 2162 0.327306988618255 3338 610414
SGTC_4 0960-0234 25.671 µM -0.44808792791315 0.362092958863992 no 2163 0.327044870065233 3279 6821112
SGTC_550 4123-0385 25.7 µM -0.449809319622494 0.361442477482715 no 2164 0.326423968654281 3193 5731123
SGTC_1448 4255-0083 152 µM -0.450595689840839 0.361145456130345 no 2165 0.32614048683379 3335 5399660
SGTC_815 1582-0027 36.9 µM -0.452085555856996 0.360582945701442 no 2166 0.3256036744328 3289 3128206
SGTC_2869 9037858 32.47 µM -0.454108125458342 0.359819791645913 no 2167 0.324875502625281 3184 27187042
SGTC_2480 5767542 37.17 µM -0.456753713633139 0.358822404236076 no 2168 0.323924039181614 3200 2867358
SGTC_1266 0828-0227 32.9 µM -0.457000129546267 0.358729554237843 no 2169 0.323835476194636 3250 3913820
SGTC_1947 st076332 61.6 µM -0.459095970541219 0.357940175203895 no 2170 0.323082625072358 3317 24208416
SGTC_2318 6029776 164 µM -0.459162918510916 0.357914969860782 no 2171 0.323058588481479 3359 818325
SGTC_149 3970-0822 46.1 µM -0.459343839710953 0.357846857661623 no 2172 0.322993635333469 3340 3114250 YBL034C STU1
SGTC_667 1498-1044 59 µM -0.460009199285253 0.357596405760391 no 2173 0.322754808723171 3234 6739982
SGTC_3125 9127534 49.47 µM -0.460316644165031 0.357480699332326 no 2174 0.322644478011532 3253 1639235
SGTC_1044 1222-0021 1.78 µM -0.461169353980408 0.357159851827048 no 2175 0.32233855340615 3258 4306703
SGTC_2686 alizarin 95.37 µM -0.461228034192404 0.357137776045952 no 2176 0.322317505272048 3228 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2805 7950783 58.44 µM -0.461834394058436 0.356909688531242 no 2177 0.322100042086993 3289 1178958 YDL195W SEC31
SGTC_1291 0993-0025 5.79 µM -0.462219323447159 0.356764920539715 no 2178 0.321962023693233 3342 4353356
SGTC_2484 5809818 12.04 µM -0.462445866191209 0.356679729780413 no 2179 0.321880807114854 3236 2870548
SGTC_2462 5162487 171.77 µM -0.464446894600926 0.355927559569224 no 2180 0.321163799404421 3315 2259986
SGTC_1420 4'-methoxyflavone 42 µM -0.466451658927819 0.355174547007089 no 2181 0.320446120966179 3306 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_996 3970-0799 1.8 µM -0.468367613592053 0.354455420469852 no 2182 0.319760862041002 3267 6615648 YGL040C HEM2
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.468585014246679 0.354373854913172 no 2183 0.319683145476287 3251 6708630 An antioxidant.
SGTC_567 1080-0542 68.4 µM -0.46958185385635 0.35399994079612 no 2184 0.319326895849301 3311 5950415
SGTC_3324 9138759 60.749 µM -0.471120003631952 0.353423257719189 no 2185 0.318777520491009 3333 45595710
SGTC_1474 0330-0125 5.35 µM -0.473269557155477 0.352617910806216 no 2186 0.318010439187312 3340 X1474
SGTC_458 nppb 133 µM -0.473959649876013 0.352359502017615 no 2187 0.3177643406482 3403 4549 A chloride channel blocker.
SGTC_228 caffeine 993.056 µM -0.475286292735118 0.351862925221585 no 2188 0.317291463894476 3327 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1440 4100-1550 40 µM -0.476125984498148 0.351548749968377 no 2189 0.316992312986617 3280 742806
SGTC_1371 2421-0008 32.7 µM -0.476620094844121 0.351363923252427 no 2190 0.316816335743338 3222 2827552
SGTC_521 r062-0005 13.8 µM -0.477070514927757 0.35119546991517 no 2191 0.316655954876484 3274 2832033
SGTC_2687 chenodiol 100 µM -0.47797221625416 0.350858329037743 no 2192 0.316334990078071 3338 5702181 A cholesterol synthesis inhibitor.
SGTC_757 1066-0008 322 µM -0.478929322943167 0.350500600850658 no 2193 0.315994454796931 3334 6842497
SGTC_2100 5377183 190 µM -0.480992425597949 0.349729946762162 no 2194 0.315260941018673 3301 2844202
SGTC_2490 carminic acid 95.39 µM -0.481985800084597 0.349359100832948 no 2195 0.314908016829682 3338 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_118 0083-0097 135.343 µM -0.483630984497527 0.348745237969309 no 2196 0.314323890562425 3378 5207356
SGTC_1086 cerivastatin 2.18 µM -0.484080760482995 0.348577483188041 no 2197 0.314164277447331 3320 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2078 5212016 200 µM -0.485472775563843 0.348058485387864 no 2198 0.31367050991584 3298 1899708
SGTC_894 0960-0238 55.9 µM -0.486320492280091 0.347742562661612 no 2199 0.313369976125879 3369 6741907 YDL195W SEC31
SGTC_710 3448-4187 58 µM -0.487336041394896 0.34736423217756 no 2200 0.313010105246649 3336 3946412
SGTC_1356 1502-0781 85.8 µM -0.488642353259554 0.346877805139542 no 2201 0.312547461293135 3244 567702
SGTC_2558 carylophyllene oxide 100 µM -0.492239592912473 0.345539618681902 no 2202 0.311274989030661 3364 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1703 st026983 48.3 µM -0.492427089699884 0.345469921907865 no 2203 0.311208726332447 3385 1104023
SGTC_1303 1160-0052 261 µM -0.493046644252265 0.345239656809803 no 2204 0.310989814862654 3341 3562476
SGTC_153 4077-0274 519.67 µM -0.4955590900073 0.344306463208486 no 2205 0.310102761121594 3495 3121976
SGTC_2734 clemastine 41.6 µM -0.498889476891402 0.343070923469971 no 2206 0.308928623893952 3296 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1603 st002045 67.8 µM -0.49894563503475 0.343050103701019 no 2207 0.308908841866877 3381 5887985
SGTC_1997 st073024 93.8 µM -0.502291693120707 0.341810466009644 no 2208 0.307731175816931 3383 686268
SGTC_1309 pyrazolanthrone 13.4 µM -0.50261305421943 0.341691498566814 no 2209 0.307618174702747 3373 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_223 busulfan 5 mM -0.503173099629504 0.341484208096432 no 2210 0.307421287969848 3357 2478 A DNA alkylator.
SGTC_659 k018-0002 107 µM -0.505430217609325 0.340649262680749 no 2211 0.306628349778832 3395 6797879 YHR007C ERG11
SGTC_3253 9135987 49.47 µM -0.505924029195469 0.340466697454165 no 2212 0.306454991431758 3371 4182430
SGTC_3088 9117578 49.47 µM -0.506215784393572 0.340358851298198 no 2213 0.306352587697751 3407 678341
SGTC_2616 abietic acid 100 µM -0.506218878344124 0.340357707701544 no 2214 0.306351501826953 3418 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2745 rifampicin 24.3 µM -0.507103816856491 0.340030673980348 no 2215 0.306040988523098 3310 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2764 methyldopa 94.69 µM -0.507939447942771 0.33972197252746 no 2216 0.305747904430629 3455 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.508032618393203 0.339687559863707 no 2217 0.305715234105497 3288 15053
SGTC_1233 0325-0408 14.2 µM -0.509328021439618 0.339209239109639 no 2218 0.305261159851605 3389 12874
SGTC_1734 st037168 69.4 µM -0.509378264496704 0.339190692338266 no 2219 0.305243554313378 3329 708907
SGTC_2195 6536160 144.242 µM -0.509689696306109 0.339075738789036 no 2220 0.305134436361 3261 3834386
SGTC_2228 7354201 200 µM -0.509818207852669 0.339028307863936 no 2221 0.305089414162089 3327 753451
SGTC_2419 paclitaxel 166.5 µM -0.511286298442776 0.338486647538856 no 2222 0.304575298884407 3326 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3079 9117512 49.47 µM -0.511638014715881 0.338356929380279 no 2223 0.304452187500916 3386 7185044
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.51173598768861 0.338320798915287 no 2224 0.30441789792753 3269 4000243
SGTC_2157 5649910 96.377 µM -0.514192974519223 0.33741519903999 no 2225 0.303558539570267 3291 2858091
SGTC_1866 st057638 64 µM -0.515580634875062 0.3369041485347 no 2226 0.303073669185303 3318 688802
SGTC_419 nsc-638432 893 µM -0.515623401018755 0.336888403304005 no 2227 0.303058731525905 3332 368090
SGTC_2271 7849410 118.62 µM -0.51697843290471 0.33638966872725 no 2228 0.302585607125272 3415 972430
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.517813489063278 0.336082460249802 no 2229 0.302294202975737 3385 17037758
SGTC_1144 3486-0183 12.5 µM -0.51832287834575 0.33589511496393 no 2230 0.302116506543019 3347 6744069
SGTC_2229 7354935 190 µM -0.518874353974301 0.335692336948712 no 2231 0.301924181506024 3354 318112
SGTC_594 1487-1584 10.8 µM -0.519465022159758 0.335475200854942 no 2232 0.301718249244434 3290 5013332
SGTC_2471 5466956 24.79 µM -0.520652810785959 0.33503872312741 no 2233 0.301304326501299 3280 724419
SGTC_1622 st003707 19.4 µM -0.521362824129538 0.334777920202046 no 2234 0.301057021934202 3404 10140899
SGTC_663 1486-0733 13.9 µM -0.524516406279979 0.333620507077148 no 2235 0.299959705885537 3321 722445 YPR165W RHO1
SGTC_1676 st018489 23.4 µM -0.526108285627853 0.333036862865363 no 2236 0.299406486060059 3341 3696235
SGTC_1181 1222-0449 220 µM -0.526294799126728 0.332968506268206 no 2237 0.299341698017972 3464 658318
SGTC_3271 9137798 49.47 µM -0.526547260464028 0.332875988841557 no 2238 0.299254012212596 3379 6498326
SGTC_509 pifithrin 175 µM -0.526795646075334 0.33278497494131 no 2239 0.29916775337824 3450 4817 A p53 inhibitor.
SGTC_1880 MG-132 525 µM -0.528767635765549 0.332062744950639 no 2240 0.298483325738395 3407 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_385 1494-0393 12.4 µM -0.529846408634733 0.331667914152985 no 2241 0.298109212730509 3344 3090647
SGTC_1801 st050089 28.441 µM -0.532087210875343 0.330848378499192 no 2242 0.297332797347856 3414 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_327 1273-0057 3.96 µM -0.532316686199801 0.330764497425577 no 2243 0.29725333863805 3364 3108138
SGTC_809 3998-0021 90 µM -0.532884293025702 0.330557054242379 no 2244 0.297056839354053 3409 715485
SGTC_2024 5144227 134 µM -0.533246372916919 0.330424752141942 no 2245 0.296931522292316 3413 3475211
SGTC_74 000s-0487 160.283 µM -0.534015568533459 0.330143762428165 no 2246 0.296665381421622 3410 677548
SGTC_1461 k072-0203 53.8 µM -0.536745017973393 0.329147459302684 no 2247 0.295721877601539 3345 5418714
SGTC_1887 st057648 70.8 µM -0.538854154991922 0.328378412320774 no 2248 0.294993746377836 3445 688672
SGTC_673 1082-0474 110 µM -0.539205252152212 0.32825046349597 no 2249 0.294872618364527 3370 3098046
SGTC_700 3453-2283 142 µM -0.543830143101369 0.326566919718017 no 2250 0.293279181998504 3482 565664
SGTC_516 3992-2719 87.3 µM -0.544412948766927 0.32635501740803 no 2251 0.293078668589165 3261 5350887 YDR037W KRS1
SGTC_2469 5655019 90.81 µM -0.54523589310179 0.326055898512307 no 2252 0.292795644169169 3460 2788239
SGTC_2491 paeonol 100 µM -0.54614830939972 0.325724389678474 no 2253 0.29248199725981 3424 11092 Increases levels of cortical cytochrome oxidase.
SGTC_102 gallobenzophenone 83.616 µM -0.547934957806609 0.325075644683204 no 2254 0.291868282141081 3496 70837
SGTC_2114 5491910 81.25 µM -0.54952699222334 0.324498011836592 no 2255 0.291321922994985 3458 2849228
SGTC_2675 theaflavin digallate 100 µM -0.549616105966388 0.324465691435385 no 2256 0.291291354784733 3434 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2148 5546263 113.568 µM -0.55022906223508 0.324243415964625 no 2257 0.291081136251264 3343 792097
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.55050486723584 0.324143421607899 no 2258 0.290986569715994 3343 2724 A muscle relaxant with antifungal properties.
SGTC_2472 5377652 49.4 µM -0.552268523062087 0.323504300322327 no 2259 0.290382196544657 3418 1610903
SGTC_2772 vinpocetine 57.06 µM -0.552608773501635 0.323381058703713 no 2260 0.290265666496161 3501 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3285 9112818 20.8695 µM -0.552677203567823 0.323356275088473 no 2261 0.290242232996162 3444 17017947 YPR165W RHO1
SGTC_1040 k898-0338 155 µM -0.552971284880463 0.323249775301379 no 2262 0.29014153655637 3503 20969351
SGTC_608 k048-0125 159 µM -0.554535929164405 0.32268339243715 no 2263 0.289606061852755 3472 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2842 9000675 19.48 µM -0.554660136031684 0.322638448606847 no 2264 0.289563573905677 3376 2989072
SGTC_364 0083-0097 67.7 µM -0.554899432858264 0.322551867173657 no 2265 0.289481724921407 3472 5207356
SGTC_2760 etidronate 98.04 µM -0.555623040674419 0.322290112804204 no 2266 0.289234288544391 3378 3305 A chelator and antioxidant.
SGTC_2846 9008642 19.48 µM -0.556284399733069 0.322050953043873 no 2267 0.2890082250107 3453 2992898
SGTC_2996 9066192 71.4286 µM -0.557224204399356 0.321711228907116 no 2268 0.288687127189125 3401 6472854
SGTC_1263 0774-1208 64.8 µM -0.558093492355514 0.321397128062259 no 2269 0.288390272076095 3517 906585
SGTC_502 l-744,832 89.3 µM -0.558583951725151 0.321219966123031 no 2270 0.288222847520302 3445 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1408 3909-7976 48.8 µM -0.55912943528167 0.321022976325976 no 2271 0.288036693626568 3444 24152374
SGTC_2742 clothiapine 36.27 µM -0.560597725984525 0.320492984683612 no 2272 0.287535901044906 3416 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_113 0099-0221 2.5 µM -0.563010387869621 0.319622909247472 no 2273 0.286713905204089 3522 89219
SGTC_1634 st006576 41 µM -0.563572236421437 0.319420432670437 no 2274 0.286522643008307 3496 3915356
SGTC_1282 0886-0010 32.4 µM -0.563756420551851 0.319354068894727 no 2275 0.28645995697339 3519 2836211 YNL267W PIK1
SGTC_3304 9125678 46.087 µM -0.567537868423822 0.317992848898027 no 2276 0.285174403059586 3419 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_413 propylparaben 100 µM -0.567577919288732 0.317978444767853 no 2277 0.285160801958463 3396 7175 A pharmaceutical preservative.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.568115059207827 0.317785291205204 no 2278 0.284978421441231 3455 442882
SGTC_2961 9083290 32.55 µM -0.56827094029805 0.317729246210322 no 2279 0.284925503983509 3462 17741490
SGTC_2853 9015042 58.44 µM -0.568317907891304 0.317712360448809 no 2280 0.284909560661653 3373 6457456
SGTC_1295 1013-0063 9.78 µM -0.569885795601661 0.317148892147207 no 2281 0.284377579794996 3500 6826038
SGTC_1946 st076057 65.1 µM -0.570419332897572 0.316957245781505 no 2282 0.284196660063263 3396 953009
SGTC_1711 st032263 62.8 µM -0.570857936687999 0.316799736256847 no 2283 0.284047973020385 3425 3958979
SGTC_2182 6325192 200 µM -0.572364826656382 0.31625884148737 no 2284 0.283537419842943 3446 736248
SGTC_440 fluspirilene 35.1 µM -0.572777125805854 0.316110916045347 no 2285 0.283397804390166 3570 3396 An atypical antipsychotic.
SGTC_3230 9131665 49.47 µM -0.574369107180433 0.315540018449496 no 2286 0.282859026718454 3419 15943720
SGTC_1307 1187-1599 12.2 µM -0.574520803692045 0.315485641773484 no 2287 0.282807713424833 3373 1538471
SGTC_2122 5258151 111.688 µM -0.574839839318423 0.315371294259394 no 2288 0.282699810119405 3403 2173356
SGTC_2069 5228469 200 µM -0.575302195514962 0.315205609723183 no 2289 0.282543468464896 3446 2835210
SGTC_3297 9117502 71.43 µM -0.575398022507987 0.31517127493583 no 2290 0.282511070616851 3472 7453720
SGTC_438 sphingosine 6.67 µM -0.577488631530031 0.314422608050762 no 2291 0.281804708096103 3317 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2776 terbinafine 19.92 µM -0.57838069771677 0.314103382640685 no 2292 0.281503561391526 3478 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2267 7931562 200 µM -0.581221144818863 0.313087857203183 no 2293 0.280545709237272 3370 934880
SGTC_844 0330-0132 15.3 µM -0.581247659140217 0.313078384381046 no 2294 0.280536775545094 3512 2828079
SGTC_335 4077-0256 27.6 µM -0.581583774555345 0.31295831048291 no 2295 0.28042353730212 3500 3121989
SGTC_356 1634-0012 32.5 µM -0.582699107650663 0.312560010982627 no 2296 0.280047937025699 3505 735457
SGTC_1394 3474-0001 65.7 µM -0.582702043179981 0.312558962956667 no 2297 0.280046948776838 3409 5017666 YIL048W NEO1
SGTC_1594 piperine 70.1 µM -0.584687384022299 0.31185051540851 no 2298 0.279378969275444 3479 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_7 0192-1582 4.227 µM -0.584959262144147 0.311753552715382 no 2299 0.279287554585266 3520 252616
SGTC_1742 st038235 28.8875 µM -0.58501078171879 0.311735180229544 no 2300 0.279270233586717 3454 564103 YBR002C RER2
SGTC_1290 0986-0249 10.2 µM -0.585667895804285 0.311500886738685 no 2301 0.279049356134307 3458 53329
SGTC_1230 0170-0365 3.77 µM -0.586251586140912 0.311292836416312 no 2302 0.278853230068541 3576 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_6 0844-0013 19.835 µM -0.586443458774711 0.311224458578407 no 2303 0.278788773506287 3572 1584900
SGTC_173 1273-0061 2.693 µM -0.586753431175288 0.311114007173549 no 2304 0.278684658526901 3452 2847414 YPL266W DIM1
SGTC_196 k015-0023 18.111 µM -0.586949036728653 0.311044316468355 no 2305 0.278618967362727 3472 5211998
SGTC_2593 nobiletin 86.24 µM -0.587126226461372 0.310981192833627 no 2306 0.278559467383096 3425 72344 An anti-infammatory.
SGTC_3195 9113082 49.47 µM -0.587381864841124 0.310890131759466 no 2307 0.278473635402205 3492 17018038
SGTC_224 benfluorex 43.875 µM -0.589006103450339 0.310311831617868 no 2308 0.27792858964452 3504 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2960 9079389 5.97 µM -0.592672458885784 0.309008172950389 no 2309 0.276700188214854 3507 16457355
SGTC_1030 k029-0042 36.7 µM -0.592899360565124 0.308927571498476 no 2310 0.27662425298858 3449 6080581
SGTC_713 1488-1073 324 µM -0.593638252349252 0.308665161453375 no 2311 0.276377045260298 3491 3312542
SGTC_1469 k284-2957 126 µM -0.59393548104994 0.308559631185881 no 2312 0.276277633350702 3494 23884841
SGTC_1984 st072354 53.1 µM -0.59528201299087 0.308081746737445 no 2313 0.275827488567997 3432 5762938
SGTC_1175 0741-0056 27.6 µM -0.595496999326988 0.308005478129819 no 2314 0.275755652146783 3569 765927
SGTC_1941 st076221 61.8 µM -0.595753319664032 0.307914556697598 no 2315 0.275670016230445 3497 2828568
SGTC_2429 5902844 64.44 µM -0.596201305595449 0.307755676347746 no 2316 0.275520376768823 3485 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2282 7944268 200 µM -0.596259429918876 0.307735064919815 no 2317 0.275500964595409 3570 2970414
SGTC_1958 st076513 41.9 µM -0.597118922240299 0.307430351767898 no 2318 0.27521399268106 3428 732122 YGL099W LSG1
SGTC_2976 9009005 19.48 µM -0.597754619360265 0.307205065490351 no 2319 0.275001837428117 3553 2993148
SGTC_2628 lathosterol 100 µM -0.598284633258402 0.307017288155487 no 2320 0.274825014124085 3568 6710616
SGTC_1215 3852-0577 11.2 µM -0.598357035002995 0.306991641045201 no 2321 0.274800863796319 3554 2884876
SGTC_1226 3909-7979 35.4 µM -0.599957801501733 0.306424837670772 no 2322 0.274267179505912 3528 6615510
SGTC_256 clotrimazole 625 nM -0.601948464245019 0.305720624552715 no 2323 0.273604221315845 3503 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3168 9103419 49.47 µM -0.603353380582753 0.305224055890835 no 2324 0.273136814323922 3482 16649256
SGTC_1183 1254-0324 198 µM -0.603531519177989 0.305161118256257 no 2325 0.273077576992409 3542 5799357
SGTC_864 0469-0573 172 µM -0.603932480118435 0.305019476979578 no 2326 0.272944266716069 3457 689425
SGTC_3227 9130768 49.47 µM -0.604654722421022 0.304764415292528 no 2327 0.272704219231421 3520 17720899
SGTC_1985 st071382 65.5 µM -0.605355633697546 0.304516977406118 no 2328 0.272471361625563 3560 6123237
SGTC_2168 5727979 200 µM -0.60547373039427 0.304475295342418 no 2329 0.272432137117762 3475 695210
SGTC_280 3448-3607 3.04 µM -0.606287872181729 0.304188014252749 no 2330 0.272161805285292 3528 626179
SGTC_588 3970-1144 52.9 µM -0.610302931070693 0.302773015565509 no 2331 0.270830577836639 3493 1888707
SGTC_3120 9124077 49.47 µM -0.611139499754827 0.302478561096377 no 2332 0.270553615958399 3546 18774327 YGL155W CDC43
SGTC_1529 apigenin 74 µM -0.611713097863139 0.30227674093073 no 2333 0.270363797261427 3611 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_9 0092-0002 10.449 µM -0.611876156871813 0.302219379743105 no 2334 0.270309848901856 3534 759368
SGTC_444 curcumin 90.4 µM -0.611919838276016 0.302204014250811 no 2335 0.27029539774652 3516 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.612509173644339 0.301996742287352 no 2336 0.270100465203662 3542 616764
SGTC_1926 methyl fluorone black 53.6 µM -0.613269260968654 0.301729510400765 no 2337 0.269849157479092 3422 72721 Reacts with homocysteine.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.613967293100732 0.301484189603787 no 2338 0.269618470229483 3525 756377
SGTC_1244 0416-0015 52.5 µM -0.614939244262333 0.301142750570391 no 2339 0.269297422246862 3533 96201
SGTC_2893 9048488 25.97 µM -0.615115111219763 0.301080988468747 no 2340 0.269239351616368 3481 6467338
SGTC_1620 st003704 16.5 µM -0.615648550635444 0.300893686674626 no 2341 0.26906325028695 3535 2834414
SGTC_140 0062-0056 502.533 µM -0.615840971094713 0.300826136704601 no 2342 0.268999741801233 3511 3758964
SGTC_2933 9026794 32.47 µM -0.617184062897312 0.300354829612343 no 2343 0.268556663224271 3492 17586027
SGTC_2145 5634607 200 µM -0.617296621462972 0.300315346613541 no 2344 0.268519547440553 3498 308662
SGTC_88 0180-0332 8.668 µM -0.617636908243528 0.300195995975916 no 2345 0.268407354777948 3570 3101745
SGTC_3337 9144342 33.5465 µM -0.618703760248837 0.299821952251129 no 2346 0.268055766193999 3526 17682949
SGTC_1172 0370-0043 85 µM -0.619576248919699 0.299516210241155 no 2347 0.267768403849479 3578 376585
SGTC_875 0709-0210 25.7 µM -0.61972633422753 0.299463630817331 no 2348 0.267718987493803 3572 6251364
SGTC_1334 1486-0610 236 µM -0.620487125282278 0.299197167087144 no 2349 0.267468563857919 3548 3742339
SGTC_1776 st049249 45.9 µM -0.620592294846849 0.299160340374859 no 2350 0.267433955311811 3516 1822314
SGTC_1101 ebselen 5.29 µM -0.620733432853054 0.299110922002433 no 2351 0.267387514044294 3606 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1714 st033236 13.627 µM -0.62084206482575 0.299072887888159 no 2352 0.267351771613381 3621 2916566
SGTC_613 3914-0030 117 µM -0.621457771096039 0.298857358946084 no 2353 0.26714923557001 3352 1145395
SGTC_319 1348-1596 45.5 µM -0.622267199219038 0.298574124790201 no 2354 0.266883092784563 3598 5380505
SGTC_1398 3558-0053 112 µM -0.622730602697433 0.298412026154967 no 2355 0.266730784426294 3462 4532369
SGTC_3018 9082602 49.47 µM -0.623154733726222 0.298263700143667 no 2356 0.266591422391231 3553 17332089
SGTC_2794 7785382 27.27 µM -0.62396869299622 0.297979138478123 no 2357 0.266324072789251 3553 2205081
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.624310828124523 0.297859564355337 no 2358 0.266211737055014 3521 77254
SGTC_2264 7948757 110.76 µM -0.624883719709407 0.297659391279706 no 2359 0.266023689088026 3538 2971411
SGTC_3096 9117468 49.47 µM -0.624887951928485 0.297657912735676 no 2360 0.266022300139822 3473 41316311
SGTC_2759 disulfiram 3.38 µM -0.625011195139041 0.297614858657194 no 2361 0.265981855253883 3514 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2978 9011784 42.97 µM -0.625991587879578 0.297272467191011 no 2362 0.265660229474437 3587 2994934
SGTC_535 2293-4129 48.2 µM -0.628702634598909 0.296326602118659 no 2363 0.264771876493836 3578 396118 YIL048W NEO1
SGTC_2465 5809242 33.21 µM -0.629099587535668 0.296188223938912 no 2364 0.264641930246161 3549 2731748
SGTC_459 nigericin 15.3 µM -0.630580250123315 0.295672325229046 no 2365 0.264157507866723 3615 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1618 st003135 44.5 µM -0.630984016643201 0.295531714891534 no 2366 0.264025487632206 3521 1270615
SGTC_913 3487-1245 167 µM -0.631230301454336 0.295445962131977 no 2367 0.263944975975539 3515 4016153
SGTC_1668 st014914 51.6 µM -0.632446141465939 0.295022792284617 no 2368 0.2635476956484 3573 2839556
SGTC_386 1509-0011 3.07 µM -0.633419524201985 0.29468421041821 no 2369 0.263229859237524 3605 3107280
SGTC_2647 atorvastatin 60.16 µM -0.633616096675639 0.294615856321552 no 2370 0.263165696653095 3552 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.634924096661635 0.294161212193503 no 2371 0.26273896017827 3624 165506
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.635225233524892 0.294056586784615 no 2372 0.262640764087468 3516 390807
SGTC_2528 xanthyletin 44.79 µM -0.635732039917471 0.293880543481231 no 2373 0.26247554473936 3584 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2219 9098279 200 µM -0.635923423343423 0.293814077580866 no 2374 0.262413167410161 3567 902349
SGTC_823 0417-1665 178 µM -0.636390551478098 0.293651877005775 no 2375 0.262260948877467 3578 3429856
SGTC_1032 k061-1018 98.7 µM -0.638134957490775 0.293046534842588 no 2376 0.261692916246943 3657 4005393
SGTC_186 3455-3465 67.277 µM -0.639234116971133 0.292665403069588 no 2377 0.261335320365547 3544 755278
SGTC_3301 9125354 19.7965 µM -0.639534381831446 0.292561326769948 no 2378 0.261237677137249 3559 41905162
SGTC_2821 7996764 71.43 µM -0.639676469469625 0.292512083061 no 2379 0.261191478146456 3669 2987135
SGTC_698 k064-0052 127 µM -0.639735831739047 0.292491510854717 no 2380 0.261172178084293 3633 5088751
SGTC_2403 6032726 181.2 µM -0.640184526508666 0.2923360358371 no 2381 0.261026320630254 3567 2881040
SGTC_108 0509-0257 621.132 µM -0.640653453106217 0.292173591471399 no 2382 0.260873931172211 3560 536624
SGTC_2932 9016711 44.54 µM -0.642156908450262 0.291653051693417 no 2383 0.260385654396192 3583 7117328
SGTC_2433 5607874 27.82 µM -0.643079528330936 0.291333828170483 no 2384 0.260086248645829 3584 2252428
SGTC_2446 5162541 200 µM -0.643930478671287 0.29103954670572 no 2385 0.259810258302612 3553 1549321
SGTC_1687 st020778 55.3625 µM -0.64468706995018 0.290778013814575 no 2386 0.259564998580342 3589 4259299
SGTC_1565 sinapyl alcohol 95.1 µM -0.646286610025139 0.290225458638555 no 2387 0.2590468789366 3568 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3174 9107204 49.47 µM -0.64682861659306 0.290038336123957 no 2388 0.258871434708235 3624 3938802
SGTC_3126 9127922 49.47 µM -0.647279886545333 0.289882582705575 no 2389 0.25872540828537 3624 45595682
SGTC_2311 7694451 200 µM -0.647431282142453 0.289830338111799 no 2390 0.258676427744241 3524 2163142
SGTC_3326 9140064 16.379 µM -0.647671758315587 0.289747362085033 no 2391 0.258598637113834 3572 1868434
SGTC_726 3448-4391 34.2 µM -0.64774906865279 0.289720688610193 no 2392 0.258573630889886 3678 1356692
SGTC_1336 1486-0901 104 µM -0.649823262858874 0.289005484388216 no 2393 0.257903195295924 3560 5006114
SGTC_148 3253-0744 288.01 µM -0.650905431162547 0.288632671252427 no 2394 0.257553767641567 3589 6893655
SGTC_2689 tacrolimus 100 µM -0.651703947320427 0.288357723223747 no 2395 0.2572960878348 3584 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_393 acivicin 6.25 µM -0.651849030820104 0.288307780797469 no 2396 0.257249284024937 3521 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3220 9131269 49.47 µM -0.652479075880277 0.288090946270796 no 2397 0.257046083393744 3634 17722206
SGTC_2667 digitoxin 100 µM -0.653595742170955 0.287706826742444 no 2398 0.256686144057201 3562 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_237 nikkomycin 200 µM -0.655382467309735 0.287092719069952 no 2399 0.256110768432172 3645 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3243 9134147 49.47 µM -0.655423981251055 0.28707845787156 no 2400 0.256097407778696 3645 24282180
SGTC_481 bay k-8644 50 µM -0.656004164559863 0.286879183813033 no 2401 0.25591072233348 3554 2303 A calcium channel antagonist.
SGTC_840 0245-0196 390 µM -0.656034206192482 0.286868867276363 no 2402 0.255901057778621 3662 3827528
SGTC_3121 9125696 49.47 µM -0.658369633499017 0.28606740145998 no 2403 0.25515032158995 3651 1235365
SGTC_204 PMA1.184 62.41 µM -0.658824477008345 0.285911433329739 no 2404 0.255004243718506 3637 2252213 YGL008C PMA1
SGTC_531 3788-1495 174 µM -0.661395771310562 0.285030484673675 no 2405 0.254179268544309 3593 2896655
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.661633955048541 0.284948946314849 no 2406 0.25410292046366 3579 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_116 0155-0182 31.788 µM -0.662156685840541 0.28477003687393 no 2407 0.253935405053787 3595 771486
SGTC_2705 st078069 42.8 µM -0.662984562511037 0.284486798169294 no 2408 0.253670220575205 3577 1530061
SGTC_273 hydroxyurea 18.1 mM -0.664415407410122 0.283997585461746 no 2409 0.253212237160352 3659 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1877 wortmannin 25 µM -0.667520394532527 0.282937362153383 no 2410 0.252219893511336 3626 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.670299182552311 0.281990136582682 no 2411 0.251333544063114 3575 279621
SGTC_1450 4112-4260 37.6 µM -0.670472363681343 0.281931153676992 no 2412 0.25127835907515 3618 1633175
SGTC_3060 1327-0027 12.5 µM -0.672735610235882 0.281160872584402 no 2413 0.250557754186818 3559 16000455 YPR107C YTH1
SGTC_2482 5981709 142.65 µM -0.675203040835239 0.280322258626008 no 2414 0.24977338748141 3620 877755
SGTC_2386 9075165 157.42 µM -0.676786214065255 0.279784818947035 no 2415 0.249270803110938 3612 16452277
SGTC_337 1315-0038 354 µM -0.679485436245403 0.278869668535737 no 2416 0.248415166185869 3643 1626437
SGTC_1555 citronellol 128 µM -0.679833859938624 0.27875164440209 no 2417 0.248304832189738 3612 8842 A terpine precursor.
SGTC_2935 9038016 29.96 µM -0.6801262559327 0.278652617712924 no 2418 0.248212260436646 3638 6463195
SGTC_744 1594-0068 283 µM -0.680210224200913 0.278624183076459 no 2419 0.248185679719931 3669 668392
SGTC_2381 9035592 200 µM -0.680347649378421 0.27857764908166 no 2420 0.248142180136756 3603 4749657
SGTC_216 k038-0035 28.382 µM -0.680751332279773 0.27844097857095 no 2421 0.248014424758182 3581 4444231 YPR107C YTH1
SGTC_1002 4049-0206 172 µM -0.681266475335058 0.2782666196748 no 2422 0.247851446055043 3678 4662749
SGTC_3032 9089427 49.47 µM -0.681956767097365 0.278033062217695 no 2423 0.247633144233615 3620 17173707
SGTC_2899 9053889 58.44 µM -0.682496718928062 0.277850438366749 no 2424 0.24746245838419 3613 6470052
SGTC_1383 3049-0032 20.7 µM -0.684039929045417 0.277328813091603 no 2425 0.246974976255695 3676 712864
SGTC_1050 3232-1156 69.3 µM -0.685117270430157 0.276964941635165 no 2426 0.246634961465957 3623 700529
SGTC_114 0364-0001 490.298 µM -0.685161709300039 0.276949937452362 no 2427 0.246620941703466 3651 4003655
SGTC_3160 9100216 49.47 µM -0.68516198675663 0.27694984377415 no 2428 0.246620854171629 3599 17191039
SGTC_471 1-acyl-paf 4 µM -0.685912407650647 0.276696534478738 no 2429 0.246384172738925 3613 16759367
SGTC_2359 9039622 200 µM -0.686967061543971 0.276340721424615 no 2430 0.246051742637554 3631 6463596
SGTC_1392 3455-1037 33.9 µM -0.68721369976663 0.276257544436435 no 2431 0.245974036251142 3664 981132
SGTC_1216 1165-0504 9.65 µM -0.687869274949302 0.276036516105767 no 2432 0.245767553309751 3651 6304004
SGTC_403 arphamenine a 50 µM -0.689529305716248 0.275477222428057 no 2433 0.245245118888881 3618 5487158 An arginine aminopeptidase inhibitor.
SGTC_1788 fluconazole 20 µM -0.692548231134737 0.274461524003923 no 2434 0.244296553995376 3645 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1340 1486-1359 257 µM -0.693462313111608 0.274154351793098 no 2435 0.244009734364952 3625 4309068
SGTC_3215 9129942 49.47 µM -0.693478516009036 0.274148908430851 no 2436 0.244004651876784 3604 17682944
SGTC_159 3970-0959 50 µM -0.693797247311368 0.274041841528284 no 2437 0.243904684575579 3739 6615653
SGTC_1645 Cervolide 78 µM -0.696154657238025 0.273250592286715 no 2438 0.243165990129063 3615 23173 A fragrance.
SGTC_886 0866-0150 153 µM -0.697785049784306 0.272704024495508 no 2439 0.242655815022885 3694 271463
SGTC_1005 4092-0690 4.4 µM -0.700811438968631 0.271690907383354 no 2440 0.241710349187026 3672 1529343
SGTC_3062 9077494 49.47 µM -0.701501297694738 0.271460232073406 no 2441 0.241495112528058 3643 16459633
SGTC_2051 5263410 176 µM -0.70155319156803 0.271442883720235 no 2442 0.241478925794928 3727 227584
SGTC_2305 7443522 69.23 µM -0.70155446893549 0.271442456697564 no 2443 0.241478527365996 3638 5415886
SGTC_1649 st011737 51.3 µM -0.701566609269973 0.271438398212532 no 2444 0.241474740642208 3682 1761035
SGTC_1763 st044482 94.5 µM -0.702921656437542 0.270985599239738 no 2445 0.241052287066966 3691 88505
SGTC_2757 clomiphene 4.22 µM -0.703016328293317 0.270953978032278 no 2446 0.241022786911688 3723 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1504 k297-0033 30 µM -0.703534889230865 0.270780806921746 no 2447 0.240861235938298 3600 4388117
SGTC_179 1273-0063 6.77 µM -0.705868524231504 0.270002184360334 no 2448 0.240134951648561 3668 3108139
SGTC_2525 harmine 47.85 µM -0.706656766204578 0.269739439013979 no 2449 0.239889901443797 3683 5280953 A monoamine oxidase inhibitor
SGTC_2097 5376186 200 µM -0.706750768674386 0.269708113641331 no 2450 0.23986068687794 3652 742755
SGTC_1457 k015-0032 57.3 µM -0.710358851484368 0.268507135406159 no 2451 0.238740816672092 3688 4302660
SGTC_2383 9036125 200 µM -0.71139350314027 0.268163240281531 no 2452 0.238420211920917 3649 79580
SGTC_1417 3966-0327 90.4 µM -0.712365860996456 0.26784025238767 no 2453 0.23811912499665 3751 651118
SGTC_3102 9121669 49.47 µM -0.712527435376682 0.267786601254779 no 2454 0.238069114298361 3720 41905072
SGTC_279 1273-0055 2.93 µM -0.715681727084075 0.266740297491025 no 2455 0.237093948175905 3736 2847562
SGTC_934 2950-0684 338 µM -0.715988463887638 0.266638660787824 no 2456 0.236999236092813 3708 1121253
SGTC_2848 9016370 25.97 µM -0.716791225875378 0.266372759714164 no 2457 0.236751463214079 3700 7894410
SGTC_3262 9137218 49.47 µM -0.719341079601492 0.265529055489793 no 2458 0.235965395365604 3559 17650664
SGTC_218 alverine citrate 93.75 µM -0.721387146203102 0.264853027753135 no 2459 0.235335676387486 3722 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2124 5246320 200 µM -0.721645345106363 0.264767780120232 no 2460 0.235256276349246 3723 579342
SGTC_766 1391-0721 126 µM -0.72213572053443 0.264605914889263 no 2461 0.235105519273905 3700 1020919 YIL115C NUP159
SGTC_1990 st072050 59.8 µM -0.723023355666621 0.264313048546346 no 2462 0.23483276763649 3710 17233948
SGTC_2502 avocadyne acetate 18.59 µM -0.72317674629901 0.26426245556881 no 2463 0.234785651645966 3680 3952079
SGTC_82 0054-0107 293.755 µM -0.72324502667698 0.264239936173328 no 2464 0.234764680092826 3707 3104697
SGTC_35 0133-0054 64.071 µM -0.72345175245451 0.264171762375707 no 2465 0.234701192900597 3679 99677
SGTC_680 0417-1641 114 µM -0.724910494402901 0.263690954862938 no 2466 0.234253471153633 3705 2835990
SGTC_1773 st048542 73.5835 µM -0.725413422426684 0.263525291198134 no 2467 0.234099220547115 3677 3237138
SGTC_3091 9116372 49.47 µM -0.726255426150254 0.263248055506519 no 2468 0.233841099646137 3730 17169793
SGTC_2292 7671323 168.05 µM -0.728234289925607 0.262597087555179 no 2469 0.233235089362092 3739 937504
SGTC_2441 5730946 39.09 µM -0.729592385105971 0.262150805097859 no 2470 0.232819689118324 3762 1774275
SGTC_1929 genistein trimethyl ether 50.5 µM -0.729680374330666 0.262121904448099 no 2471 0.232792790062038 3714 136420
SGTC_3146 9095609 49.47 µM -0.73006068710834 0.261997006954259 no 2472 0.232676545068004 3786 17173999
SGTC_1800 st050079 29.0735 µM -0.730465571360227 0.261864073546726 no 2473 0.232552825114364 3666 3645560
SGTC_749 1000-0129 128 µM -0.731021672014032 0.261681548494075 no 2474 0.232382957796296 3757 708470
SGTC_2239 6685329 187.64 µM -0.731750037268409 0.261442581018085 no 2475 0.232160574719097 3759 805680
SGTC_2693 st077581 40.7 µM -0.732092270140053 0.261330337427226 no 2476 0.232056125752573 3777 25238761
SGTC_696 1560-0013 611 µM -0.732208180863062 0.261292327299852 no 2477 0.232020755902806 3761 1650269
SGTC_2552 juarezic acid 87.02 µM -0.73300266963807 0.261031870331546 no 2478 0.231778400572193 3767 1549512
SGTC_738 1315-0003 72.4 µM -0.733451528876477 0.260884779999577 no 2479 0.231641540393423 3726 6251474
SGTC_2457 5731572 11.68 µM -0.735934085196017 0.260072021575028 no 2480 0.230885406347003 3760 2865357
SGTC_1229 0139-0193 12.2 µM -0.736648837861621 0.259838262607338 no 2481 0.230667963627007 3752 3090752
SGTC_1782 st039423 80.636 µM -0.737526370651275 0.259551414918178 no 2482 0.230401156318803 3749 2068169
SGTC_1412 3909-8563 178 µM -0.737844299861601 0.25944753066735 no 2483 0.230304534905456 3805 23767530
SGTC_3061 glucosamine 200 µM -0.737936674743782 0.259417350945543 no 2484 0.230276465635422 3653 91431 and experimental redox chemotherapeutic
SGTC_3114 9122766 49.47 µM -0.738108582983731 0.259361191773815 no 2485 0.230224234247693 3727 17176985
SGTC_2629 bisabolol 100 µM -0.738377268703938 0.259273429811209 no 2486 0.230142611946232 3746 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1411 3909-8223 150 µM -0.739101039372934 0.259037097883705 no 2487 0.229922822884805 3732 X1411
SGTC_1875 nocodazole 6 µM -0.739253470433675 0.258987338966302 no 2488 0.229876548785588 3709 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_162 k030-0015 37.8 µM -0.739774745909259 0.258817213486703 no 2489 0.229718342537485 3792 1809920 YMR134W ERG29
SGTC_3211 9128781 49.47 µM -0.74016319210235 0.258690476298363 no 2490 0.229600489419355 3783 17194361
SGTC_254 nsc-64875 3.808 µM -0.740849414465736 0.258466663093573 no 2491 0.229392374924266 3764 56993
SGTC_3310 9130229 44.1445 µM -0.74106625012426 0.258395962441246 no 2492 0.229326635951401 3799 7761258
SGTC_163 TUB2.036 7.546 µM -0.741105901261135 0.258383035018375 no 2493 0.229314615892836 3788 15992207 YJR013W GPI14
SGTC_379 3970-0972 5.9 µM -0.742091053674555 0.258061954326785 no 2494 0.229016084928269 3745 2898042 YBL034C STU1
SGTC_1382 3002-2117 298 µM -0.742178346256297 0.25803351392773 no 2495 0.228989643157255 3778 1497314
SGTC_3024 9090631 49.47 µM -0.742457751451 0.257942493122117 no 2496 0.228905020126432 3677 25236383
SGTC_3107 9121808 49.47 µM -0.743834347969394 0.257494287642281 no 2497 0.228488348749305 3667 662681
SGTC_400 oxethazaine 37.5 µM -0.743884840507553 0.257477855493082 no 2498 0.228473073657963 3759 4621 A local anesthetic.
SGTC_808 0711-0032 135 µM -0.744188631592769 0.257379002078723 no 2499 0.228381182355987 3703 4252555
SGTC_1635 st007035 42.4 µM -0.744476738711355 0.257285270440305 no 2500 0.228294054361136 3737 3716403
SGTC_1889 st059080 5.18 µM -0.74522637704721 0.257041469215654 no 2501 0.22806743984524 3722 176925 Isolated from Daphnopsis sellowiana.
SGTC_1974 st069448 26.9 µM -0.746357816588459 0.25667372432581 no 2502 0.227725647098891 3713 6323587 YNR016C ACC1
SGTC_1708 st033234 31.827 µM -0.747299650901538 0.256367814731584 no 2503 0.227441351584065 3844 674664
SGTC_2060 5238662 140 µM -0.74805182812978 0.256123642659192 no 2504 0.227214448286976 3735 790130
SGTC_3177 9107506 49.47 µM -0.74925215511499 0.255734243379342 no 2505 0.226852619612646 3672 8897194
SGTC_2159 5658611 73.75 µM -0.749311130484186 0.255715119090323 no 2506 0.226834850355063 3744 793844
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.749340593167944 0.255705565332693 no 2507 0.226825973553138 3796 5379071
SGTC_2636 apigenin dimethyl ether 100 µM -0.749739005278182 0.255576391984806 no 2508 0.226705955349169 3753 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1669 st015249 58.4 µM -0.751197809243097 0.255103708971117 no 2509 0.226266809235888 3830 722793
SGTC_1358 1509-0022 2.48 µM -0.753791914275197 0.25426429552012 no 2510 0.225487089968615 3792 3258434
SGTC_432 NS 1619 61.3 µM -0.754560186513551 0.254015972396749 no 2511 0.225256459933726 3821 4552 A K+/calcium channel activator.
SGTC_2765 myclobutanil 7.74 µM -0.755017246458635 0.253868300579587 no 2512 0.225119317093379 3782 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_758 0868-0029 16 µM -0.755409555067266 0.253741585263697 no 2513 0.225001640912695 3820 762687
SGTC_795 0685-0265 78 µM -0.75548460701704 0.253717347338668 no 2514 0.224979132438752 3809 302754
SGTC_259 usnic acid 108.925 µM -0.758230877084106 0.252831279996334 no 2515 0.224156389798518 3832 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_87 0100-0052 35.5 µM -0.758281652294248 0.252814913034899 no 2516 0.224141194388171 3835 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2106 5357045 167.29 µM -0.758349397537386 0.252793076794826 no 2517 0.224120921296073 3799 668842
SGTC_3135 9127742 49.47 µM -0.759400864391462 0.25245428614002 no 2518 0.223806398301807 3837 3643468
SGTC_3169 9102970 49.47 µM -0.760687390740037 0.252040083241438 no 2519 0.22342190398347 3836 17027839
SGTC_2898 9056270 58.44 µM -0.761373446790787 0.251819351106249 no 2520 0.223217021381779 3722 19154699
SGTC_901 1112-0062 60.1 µM -0.762870657405879 0.251337992173457 no 2521 0.222770268554546 3775 1908457
SGTC_1657 st012939 43.4 µM -0.765266042710614 0.250568879473054 no 2522 0.222056570113806 3782 24207257
SGTC_1583 clindamycin 39.6 µM -0.765559131528826 0.250474859912388 no 2523 0.22196933482406 3754 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_792 4534-1957 155 µM -0.765707827490794 0.250427167087733 no 2524 0.221925084271816 3756 1717904
SGTC_1103 duloxetine 36.1 µM -0.767871449022268 0.249733750800473 no 2525 0.221281780563195 3882 60835 A selective serotonin reuptake inhibitor.
SGTC_2057 5236571 38.335 µM -0.76821958358981 0.249622272902548 no 2526 0.221178370363475 3764 54684039 YBR257W POP4
SGTC_2394 5221648 200 µM -0.768470120246035 0.249542063675588 no 2527 0.221103967844233 3862 788586
SGTC_1684 st024538 14.6195 µM -0.769262368367188 0.249288515845278 no 2528 0.220868786138249 3763 6732859
SGTC_3200 9114385 49.47 µM -0.77147091652378 0.248582424933155 no 2529 0.220213927339355 3798 17018030 YLR208W SEC13
SGTC_1909 st060837 51.5 µM -0.771731919837827 0.248499050490545 no 2530 0.220136610622155 3813 678937
SGTC_2521 angolensin 13.4 µM -0.771783467310566 0.248482586018095 no 2531 0.220121342613805 3838 821428 A flavenoid.
SGTC_1393 3470-5649 58.2 µM -0.772586095775044 0.248226298230887 no 2532 0.219883687930387 3752 4108395
SGTC_628 1636-0253 16 µM -0.773541409912211 0.247921440115373 no 2533 0.219601015738317 3812 4456143
SGTC_347 4534-1311 26.2 µM -0.774038763648545 0.247762804624507 no 2534 0.219453934153804 3788 2862016
SGTC_620 0109-0052 432 µM -0.774662191869882 0.247564033102892 no 2535 0.219269648731215 3755 493037
SGTC_1090 efavirenz 20.7 µM -0.775115403682043 0.247419586238914 no 2536 0.219135735142496 3854 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2330 7979373 200 µM -0.776741478164396 0.246901697605461 no 2537 0.218655655003408 3771 1863007
SGTC_859 0439-0102 54.6 µM -0.777657599057308 0.246610177876462 no 2538 0.218385447491434 3779 610143
SGTC_221 trifluoperazine 10.304 µM -0.778828915883999 0.246237720716302 no 2539 0.218040250912715 3787 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_96 0929-0093 37.281 µM -0.779676673364761 0.245968337726167 no 2540 0.217790606239105 3773 6991579
SGTC_1168 k815-0004 80.5 µM -0.780608326467206 0.24567247857949 no 2541 0.21751644652623 3779 642433
SGTC_2037 5169046 200 µM -0.781407842669634 0.245418733756666 no 2542 0.217281329954728 3866 5718022
SGTC_331 k048-0133 24.5 µM -0.784340510046139 0.244489191424242 no 2543 0.216420167648744 3784 6813582
SGTC_1961 st076550 68.7 µM -0.784391041239227 0.244473191626397 no 2544 0.216405346761853 3806 1579337
SGTC_420 mitomycin C 81.9 mM -0.78443562410928 0.244459075727002 no 2545 0.216392271016239 3791 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1361 1608-0041 5.61 µM -0.784998057228369 0.244281034976332 no 2546 0.216227353832803 3764 X1361
SGTC_266 formosanin C 406 nM -0.785741408419306 0.244045831070213 no 2547 0.21600949936771 3751 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1426 4048-4480 71.7 µM -0.787202616944607 0.243583846051437 no 2548 0.215581632774516 3785 14224343
SGTC_2912 7964298 10.93 µM -0.787555615253986 0.243472310726483 no 2549 0.215478342647449 3867 2975850
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.788902222744823 0.243047082566228 no 2550 0.215084578246747 3841 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_714 4296-0578 26.1 µM -0.79044923352599 0.242559067788873 no 2551 0.214632729554969 3855 1589775
SGTC_675 1309-0189 238 µM -0.791252047857878 0.24230602400374 no 2552 0.21439846230491 3850 4246530
SGTC_1182 1222-0449 220 µM -0.791646109991037 0.242181869599342 no 2553 0.214283526444483 3821 658318
SGTC_285 1486-1325 46 µM -0.794235019128619 0.241367058275219 no 2554 0.213529312648227 3842 22310230
SGTC_991 3996-0057 64.7 µM -0.794871011234052 0.241167119634701 no 2555 0.213344269253431 3873 715343
SGTC_637 1181-0519 7.26 µM -0.794951820868643 0.24114172172875 no 2556 0.213320764196527 3833 6252091 YGR060W ERG25
SGTC_2588 indole-3-carbinol 100 µM -0.796673797200784 0.240600862313689 no 2557 0.212820252810164 3864 3712 Induces cell cycle arrest.
SGTC_174 3553-0389 74.3 µM -0.797089454526216 0.240470406588028 no 2558 0.212699540213604 3821 738071
SGTC_2743 auranofin 4.32 µM -0.79799502819053 0.240186322079441 no 2559 0.21243668765348 3776 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_150 3970-0969 77.2 µM -0.798792898419841 0.239936176507758 no 2560 0.212205254527029 3921 6615640
SGTC_2163 5671233 125 µM -0.799107959755444 0.239837438688068 no 2561 0.212113907301791 3831 701023
SGTC_1243 0416-0003 5.65 µM -0.799299955475609 0.239777279564792 no 2562 0.212058252349469 3846 2141977
SGTC_1643 st009866 20.2 µM -0.799415590546886 0.239741050935746 no 2563 0.212024736637699 3797 3156273 YOR207C RET1
SGTC_993 3909-8757 62.7 µM -0.799541827450476 0.239701504148269 no 2564 0.21198815162409 3802 4288324 YLR208W SEC13
SGTC_902 1120-0002 2.07 µM -0.800407585984156 0.239430380134375 no 2565 0.211737343618097 3823 3280475
SGTC_1377 2944-0135 198 µM -0.801024149511062 0.239237397062172 no 2566 0.211558832680851 3893 1894137
SGTC_1354 1498-1681 81 µM -0.803992849844449 0.238309391027009 no 2567 0.210700552216259 3888 5754243
SGTC_287 k060-0039 29.6 µM -0.80522636897799 0.237924377583592 no 2568 0.210344531265312 3859 5861974
SGTC_20 0481-0013 4.944 µM -0.805579042806343 0.237814361624409 no 2569 0.210242806749263 3863 182045
SGTC_1741 st038134 10.228 µM -0.807451052025107 0.237230859108072 no 2570 0.209703332131178 3893 1272587
SGTC_1251 0490-5699 265 µM -0.810120623418218 0.236400119730685 no 2571 0.20893542614638 3859 3883818
SGTC_1265 0819-1001 68.8 µM -0.810464284923889 0.236293292759865 no 2572 0.208836691914659 3814 3106768
SGTC_626 0214-0009 33 µM -0.811063230142188 0.236107174551928 no 2573 0.208664680185877 3906 3437874
SGTC_2865 9030313 51.95 µM -0.812361617746638 0.235703986754545 no 2574 0.208292081704428 3796 42562754
SGTC_468 gf-109203x 121 µM -0.812444979216353 0.235678113527819 no 2575 0.208268172867996 3796 2396 A protein kinase C inhibitor.
SGTC_2712 st079126 47.7 µM -0.812688578086665 0.235602515767036 no 2576 0.208198315750356 3839 3152970
SGTC_377 3970-0964 33.1 µM -0.813331313996082 0.235403115209166 no 2577 0.208014064042853 3829 16481235
SGTC_3 0833-0587 95.581 µM -0.815038428514371 0.234873957366489 no 2578 0.207525156825663 3785 5382644
SGTC_3022 9087993 49.47 µM -0.815334013536714 0.23478240107636 no 2579 0.207440572100455 3881 17173644
SGTC_1121 fusaric acid 630.51 nM -0.816249130822184 0.234499072253701 no 2580 0.207178831026329 3866 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1781 st038725 66.3 µM -0.816564803819517 0.234401380853744 no 2581 0.207088587834597 3852 4270275 YIL048W NEO1
SGTC_313 3474-0040 5.03 µM -0.816667692200585 0.234369544828148 no 2582 0.207059179587749 3843 1043375 YIL048W NEO1
SGTC_538 2922-0838 53.3 µM -0.816758628921048 0.234341408912723 no 2583 0.207033189501727 3843 777039
SGTC_2423 st077119 87.2 µM -0.817977216171758 0.233964557176189 no 2584 0.206685098563851 3796 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1840 st055363 71 µM -0.818629754247066 0.233762895938307 no 2585 0.206498842827788 3895 676033
SGTC_1856 st057054 55.7 µM -0.819553508943867 0.233477582355056 no 2586 0.206235343066682 3848 1266018
SGTC_1514 1189-1591 158 µM -0.821402300087114 0.232907139877858 no 2587 0.205708576926776 3900 767698 YMR146C TIF34
SGTC_873 0591-4978 488 µM -0.825308990439176 0.23170428525924 no 2588 0.204598094476309 3917 3305145
SGTC_1082 camptothecin 424.86 nM -0.825825975652976 0.231545367296079 no 2589 0.204451408380218 3800 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.828156661800481 0.230829684126049 no 2590 0.203790891908607 3938 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1151 3909-8316 15.3 µM -0.829283517125636 0.230484104491996 no 2591 0.203471997802775 3921 800431
SGTC_473 2-arachidonoylglycerol 10 µM -0.830310505571074 0.23016940368823 no 2592 0.203181624928001 3741 5282280 An endocannabinoid.
SGTC_855 0428-0020 25 µM -0.830483948726783 0.230116279113438 no 2593 0.203132609671742 3881 6812414
SGTC_2050 5263056 171 µM -0.830500454524788 0.230111223846254 no 2594 0.203127945480128 3904 763468 YGL055W OLE1
SGTC_326 k292-0812 17.5 µM -0.83129705826438 0.229867320134924 no 2595 0.202902918017226 3830 3579357
SGTC_2181 6316240 54.2555 µM -0.833255397399028 0.229268332567435 no 2596 0.202350352742511 3901 12779990
SGTC_3180 9109287 49.47 µM -0.834674905405482 0.228834702273644 no 2597 0.201950387311627 3930 18891271
SGTC_2241 6772625 37.8075 µM -0.836445038344862 0.228294608866337 no 2598 0.201452292161229 3792 2285411
SGTC_36 0335-0881 14.2 µM -0.837221738195026 0.22805785274947 no 2599 0.201233970304298 3804 23828853
SGTC_258 haloperidol 50.781 µM -0.837355952302137 0.228016955175757 no 2600 0.201196258562464 3922 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2723 salbutamol 83.58 µM -0.838544608491896 0.227654929281845 no 2601 0.200862452621592 3874 9884233 β2-adrenoceptor agonist
SGTC_877 0771-0151 33.1 µM -0.83981803951535 0.227267443029745 no 2602 0.200505208654528 3924 6166523
SGTC_2940 9060638 45.86 µM -0.839913506016755 0.227238408966758 no 2603 0.200478442194189 3906 4027022
SGTC_441 propafenone 146 µM -0.841175976160953 0.226854652750987 no 2604 0.200124678475437 3868 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2411 st077133 39.94 µM -0.841230870525704 0.226837974671177 no 2605 0.200109304739965 4008 1403142 YNL221C POP1
SGTC_3276 9139060 49.47 µM -0.841291020596419 0.226819700589951 no 2606 0.200092459904731 3962 4870619
SGTC_3270 9137563 49.47 µM -0.843090246590838 0.226273465205279 no 2607 0.199588986573375 3885 17015724
SGTC_2844 9010103 25.97 µM -0.843447672927731 0.226165041028348 no 2608 0.199489059616658 3963 2480525
SGTC_3012 9080433 71.4286 µM -0.845485102006964 0.225547554146856 no 2609 0.198920023609176 3862 17688859
SGTC_3072 9116419 49.47 µM -0.846716959446955 0.225174676463326 no 2610 0.198576451712882 3929 17170162
SGTC_3207 9114163 49.47 µM -0.847385718743208 0.224972392382852 no 2611 0.198390081017728 3911 849233
SGTC_2256 7954252 200 µM -0.847485243815369 0.224942297177826 no 2612 0.198362354268783 3923 2972920
SGTC_399 oxolinic acid 75 µM -0.848571088812006 0.224614098787863 no 2613 0.198060000023015 3867 4628 A DNA gyrase inhibitor.
SGTC_367 0335-0881 7.1 µM -0.84875018182129 0.224559993746876 no 2614 0.198010158207271 3898 23828853
SGTC_2395 5646831 180.19 µM -0.849127367028976 0.224446068087685 no 2615 0.197905211856172 3921 6808628
SGTC_1906 st060206 94.7 µM -0.849199078310369 0.22442441200223 no 2616 0.197885263026986 3921 5133468
SGTC_2652 actinonin 100 µM -0.84944599187044 0.224349855663246 no 2617 0.197816585268534 3884 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2428 5615643 7.78 µM -0.849747751528653 0.224258757463519 no 2618 0.197732671902462 3944 2253075
SGTC_3051 9093778 49.47 µM -0.849861648993796 0.224224378427039 no 2619 0.19770100487275 3933 17217378
SGTC_2120 5538279 151.968 µM -0.850404307547102 0.224060622395453 no 2620 0.19755017104839 3887 2058197
SGTC_2875 9039966 71.43 µM -0.850525064937897 0.224024191134695 no 2621 0.197516615578958 3943 6463691
SGTC_1644 st010134 20.9 µM -0.850736894524295 0.223960292460573 no 2622 0.197457761740965 3870 3818134
SGTC_2941 9056145 11.23 µM -0.852376831483112 0.223465953874753 no 2623 0.19700248749723 3764 2119517
SGTC_142 0335-0849 62.6745 µM -0.854728223207443 0.222758240363426 no 2624 0.196350811109577 3918 3889043 YPR107C YTH1
SGTC_1758 st042942 75.2445 µM -0.855900168560523 0.222405989916356 no 2625 0.196026500863719 3835 669317
SGTC_499 genistein 192 µM -0.856384428298646 0.222260529264526 no 2626 0.19589258749907 3915 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2849 9019321 12.99 µM -0.85715275350476 0.222029853205223 no 2627 0.195680234848225 3928 16489627
SGTC_1056 3448-1962 115 µM -0.858247744310661 0.22170133789563 no 2628 0.195377838719956 3905 715507
SGTC_357 1325-0123 420 µM -0.85921450059766 0.221411526040636 no 2629 0.195111092339796 3958 1098503
SGTC_2650 prasterone 100 µM -0.860098012301265 0.221146858586962 no 2630 0.194867508411657 3873 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_742 0kpi-0133 140 µM -0.860105177728026 0.221144712830152 no 2631 0.194865533661848 3980 2728852
SGTC_1671 st016596 74.5 µM -0.860641475845333 0.220984146950855 no 2632 0.194717767575115 3967 2829167
SGTC_1192 1488-0095 21.4 µM -0.86129562047702 0.220788388578509 no 2633 0.19453762357745 3973 915875
SGTC_1113 artemisinin 1.17947 µM -0.861480323541627 0.220733132591062 no 2634 0.194486776821364 3943 2240 An anti-malaria and mitochondrial poison.
SGTC_848 0368-0089 85.6 µM -0.862735834226289 0.220357742482142 no 2635 0.194141362727642 3932 762535
SGTC_2738 aclarubicin 5.55 µM -0.864036021677585 0.21996938030345 no 2636 0.193784051372503 3863 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1368 1852-0141 284 µM -0.864120924978438 0.219944033604076 no 2637 0.193760732602062 3926 2838987
SGTC_3260 9137109 49.47 µM -0.865140860352189 0.219639677108671 no 2638 0.19348074013183 3829 17478346
SGTC_3346 9158254 43.5805 µM -0.866846336204903 0.219131290814346 no 2639 0.193013104969773 3941 17639500
SGTC_1943 st076331 65.2 µM -0.866936343234518 0.219104479374858 no 2640 0.19298844456422 3956 24208415
SGTC_1624 st003710 6.25 µM -0.867179461489513 0.219032068345296 no 2641 0.192921843887784 3949 24207033
SGTC_2767 sibutramine 71.45 µM -0.867759393954203 0.218859395198507 no 2642 0.192763031823755 3908 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_869 0564-0080 44.1 µM -0.869222664132641 0.2184240591843 no 2643 0.192362676617243 3950 6843321
SGTC_2475 5812728 15.03 µM -0.869937667944582 0.218211520648957 no 2644 0.192167234452511 3903 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3290 9121031 71.43 µM -0.87203365460577 0.217589165074033 no 2645 0.191595008981947 3938 17014854
SGTC_3005 9076496 71.4286 µM -0.882148346278319 0.214600273361377 no 2646 0.188848295334549 3943 21368410
SGTC_912 3474-0017 2.18 µM -0.882842164490609 0.214396128443165 no 2647 0.188660777771856 3996 3360550
SGTC_1673 st016611 27.3 µM -0.882896891889833 0.214380030587585 no 2648 0.188645991537324 3988 5226799
SGTC_684 1140-0066 328 µM -0.885031414352729 0.213752717519318 no 2649 0.188069844245394 4016 6813534
SGTC_785 1270-0111 65.3 µM -0.885665061676561 0.213566701423183 no 2650 0.187899020338784 3891 6741994
SGTC_2496 diffractaic acid 79.83 µM -0.887458959848186 0.213040589152043 no 2651 0.187415926161281 3935 94870 An apoptosis inducer which activates caspases.
SGTC_2115 tiliquinol 12.7705 µM -0.888411265285557 0.212761605693725 no 2652 0.187159783925772 3942 71208 A bioactive hydroxyquinoline.
SGTC_3236 9132701 49.47 µM -0.88858726147389 0.212710069939955 no 2653 0.187112469826468 3956 24282524
SGTC_2283 7944793 200 µM -0.888753960118354 0.212661263443866 no 2654 0.187067662063837 3989 2970533
SGTC_2350 9023895 38.85 µM -0.888789231811343 0.212650937337064 no 2655 0.187058182059859 3987 2997209
SGTC_1152 3909-8331 15.9 µM -0.889340476717436 0.212489593459793 no 2656 0.186910062098871 3927 16001939
SGTC_2208 7283366 200 µM -0.889795208371649 0.212356551891059 no 2657 0.18678792997201 3912 898663
SGTC_2324 6149169 200 µM -0.890587345745551 0.21212491127795 no 2658 0.186575295194342 3876 2888231
SGTC_1716 st033144 30.6155 µM -0.890590071361542 0.212124114495364 no 2659 0.186574563811478 3947 674617
SGTC_2277 7947813 106.88 µM -0.892109324758576 0.211680261717764 no 2660 0.186167168656197 4048 1246798
SGTC_3286 9117135 37.221 µM -0.892892770480062 0.211451589147209 no 2661 0.185957299518215 3935 3438150
SGTC_11 0438-0307 1.3 µM -0.893147181429759 0.21137736266566 no 2662 0.185889179576558 3941 4011476
SGTC_1096 rimcazole 32.2 µM -0.893873715098708 0.211165474547029 no 2663 0.185694731371875 3890 18528119 A dopamine reuptake inhibitor.
SGTC_1419 3993-2473 62.6 µM -0.894482661952209 0.210987975663288 no 2664 0.18553185114232 4022 704026
SGTC_1306 1185-0270 9.02 µM -0.895014861226151 0.210832919199852 no 2665 0.185389571876702 3989 1548076
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.896777795963306 0.210319765054836 no 2666 0.184918749224225 4006 4174840
SGTC_1907 st060210 83.7 µM -0.897776132869957 0.210029495185562 no 2667 0.184652455670843 4017 688793
SGTC_2685 mycophenolic acid 18.85 µM -0.898105014095738 0.209933923412723 no 2668 0.184564783064086 3937 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.899615568506657 0.209495289803299 no 2669 0.184162434592097 3928 2333 A French combination drug.
SGTC_1969 st069479 40.1 µM -0.900862738772341 0.209133544153479 no 2670 0.183830652413764 3981 3895485
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.901922923076935 0.208826323774499 no 2671 0.183548906687449 4048 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2310 7668677 200 µM -0.901932390195031 0.208823581589926 no 2672 0.183546391998143 3973 2197143
SGTC_2165 5727197 32.143 µM -0.902454914177332 0.208672263557259 no 2673 0.183407630633921 4152 1361712
SGTC_1060 3448-7350 82 µM -0.902614089956501 0.208626180594101 no 2674 0.183365372944987 3935 570178
SGTC_2135 5326629 150.42 µM -0.902693715109265 0.208603130575746 no 2675 0.183344236485961 3941 5020077
SGTC_168 3970-0862 530.542 µM -0.907091788870095 0.207332302210819 no 2676 0.18217912994079 3961 3135186
SGTC_2355 9061122 103.12 µM -0.907141499719422 0.207317964416737 no 2677 0.182165987399844 4001 5302957
SGTC_3267 9137951 49.47 µM -0.907369300369021 0.207252268777772 no 2678 0.182105769106122 4001 16643986
SGTC_2564 betulinic acid 100 µM -0.90832013416107 0.206978189911544 no 2679 0.181854553961885 4049 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1680 diphenhydramine 100 µM -0.908509670102191 0.206923581621379 no 2680 0.181804503520792 3992 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2909 7941780 10.49 µM -0.916848757488066 0.204529409891067 no 2681 0.179610949446366 3943 1243215
SGTC_350 k064-0020 19.8 µM -0.919175035898714 0.203864482138011 no 2682 0.179002013227651 3997 2790705
SGTC_2957 9076800 11.52 µM -0.9193367110993 0.20381831791893 no 2683 0.178959740794537 3961 16459615
SGTC_2270 7924575 90.91 µM -0.919914071523506 0.203653511136883 no 2684 0.178808832435622 4006 1262135
SGTC_834 0312-0008 75.7 µM -0.921843586433751 0.203103310425216 no 2685 0.178305084284587 3991 6385573 YIL048W NEO1
SGTC_569 4130-2812 160 µM -0.921930723823168 0.203078484181468 no 2686 0.178282356013655 3809 743552
SGTC_986 1493-0483 84 µM -0.921995035018564 0.203060162492498 no 2687 0.178265582729039 3919 40079
SGTC_2592 piperlongumine 83.33 µM -0.922010865162489 0.203055652776323 no 2688 0.178261454152381 4019 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_284 0988-0104 32.6 µM -0.922227043875068 0.202994073431174 no 2689 0.17820507974859 3980 4666532
SGTC_668 1682-0499 62.6 µM -0.924234607918759 0.202422743877186 no 2690 0.177682090341054 3990 682214
SGTC_2092 5303694 80.6725 µM -0.925377004921724 0.202098060569399 no 2691 0.177384917912679 3999 1963699
SGTC_571 k831-0106 44.2 µM -0.926468249291494 0.20178820667506 no 2692 0.177101345064073 3887 4783639
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.92748239110127 0.201500500894425 no 2693 0.176838065127201 4043 6708760
SGTC_2762 leflunomide 42.06 µM -0.928646305851422 0.201170608561905 no 2694 0.176536207905904 3970 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_121 0557-0495 61.343 µM -0.928675278124759 0.201162400984904 no 2695 0.176528698207435 4119 3104427
SGTC_1245 0418-0076 17.2 µM -0.936626667572266 0.198917443212346 no 2696 0.174475314765771 4074 6790114
SGTC_3217 9129673 49.47 µM -0.941168630850324 0.197641890436181 no 2697 0.173309224702942 4057 17248312
SGTC_85 0868-0259 160.055 µM -0.941355727933826 0.197589452833205 no 2698 0.173261296607953 3959 83173
SGTC_2797 7859098 81.82 µM -0.942231054176717 0.197344237332104 no 2699 0.173037179048459 4014 972681
SGTC_1559 coumarin 343 70.1 µM -0.942248566679034 0.19733933322637 no 2700 0.173032697052021 4059 108770 A hepatotoxic, DNA x-linker.
SGTC_3223 9129970 49.47 µM -0.942391923627353 0.197299191099075 no 2701 0.172996010311112 4048 17248386
SGTC_2828 7998861 71.43 µM -0.94276126362945 0.197195793035044 no 2702 0.172901514662838 3978 2988188
SGTC_1468 k284-1086 134 µM -0.942804800868545 0.197183606788593 no 2703 0.172890377826679 4009 15996457
SGTC_2894 9048625 32.47 µM -0.944267043220171 0.196774584024268 no 2704 0.172516601398639 3994 4092861
SGTC_1878 temozolomide 1 mM -0.944435294066023 0.196727553383364 no 2705 0.172473626426727 3915 5394 DNA alkylating agent.
SGTC_1273 0849-0096 14.1 µM -0.945280892030642 0.196491289093925 no 2706 0.172257745480009 4047 5286025
SGTC_3344 9148862 3.898 µM -0.945828378522104 0.196338410379583 no 2707 0.172118064309837 4077 4905352
SGTC_2930 9013230 14.89 µM -0.945965068410626 0.196300252699111 no 2708 0.172083201664089 4049 2995857
SGTC_735 3076-0345 636 µM -0.94859865712627 0.195565950997041 no 2709 0.171412387128283 4095 2888990
SGTC_81 0411-0046 9.971 µM -0.949413937899402 0.195338971543384 no 2710 0.171205062141103 3968 12925265
SGTC_1333 1482-0047 286 µM -0.949998238701118 0.195176396908089 no 2711 0.171056573782788 4030 3811116
SGTC_225 nsc-122657 1.016 µM -0.95000606811484 0.195174219026825 no 2712 0.171054584653395 4036 275685
SGTC_1147 3809-1045 12.3 µM -0.95213328622196 0.194583045289161 no 2713 0.170514694858361 4006 325925
SGTC_1796 st049173 110.4 µM -0.952136549344295 0.194582139274921 no 2714 0.170513867514168 3975 94134
SGTC_2 0422-0095 29 µM -0.954784927290823 0.193847657158057 no 2715 0.169843235624797 3920 6790840
SGTC_2303 7774051 200 µM -0.954972238432789 0.193795773696125 no 2716 0.169795868140518 4058 2953184
SGTC_2948 9070189 9.45 µM -0.955094356611071 0.193761952643929 no 2717 0.169764991299621 3987 6473636 YDL196W YDL196W
SGTC_2478 5763493 32.33 µM -0.955382698180362 0.193682109728186 no 2718 0.169692100171941 3972 1365576 YLR208W SEC13
SGTC_1311 1190-0148 100 µM -0.957827920857026 0.19300582465534 no 2719 0.169074768732543 4100 1961333
SGTC_84 0443-0269 128.823 µM -0.95944149434323 0.192560342897614 no 2720 0.168668189931889 3912 6150058
SGTC_1950 st077106 7.18 µM -0.959611207784516 0.192513524295543 no 2721 0.168625463085968 4013 13831864
SGTC_2546 rhodinyl acetate 100 µM -0.95986973485117 0.192442218182329 no 2722 0.16856039000405 3985 6708682
SGTC_1557 sumaresinolic acid 42.3 µM -0.961010976171778 0.192127637656497 no 2723 0.168273324493045 4015 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_191 3914-0123 66.505 µM -0.962136069600231 0.191817816433901 no 2724 0.167990628807899 4006 3144412
SGTC_2913 7966556 36.57 µM -0.962296102694307 0.191773772379055 no 2725 0.167950443068141 3908 2976516
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.962809489993914 0.191632520540026 no 2726 0.167821568698197 4068 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_480 am 92016 50 µM -0.962992952620134 0.191582058643118 no 2727 0.167775529965349 4011 2129 K+ channel blocker.
SGTC_963 1269-2853 151 µM -0.963071102822944 0.191560565688529 no 2728 0.167755921158868 4037 3668223
SGTC_1003 4049-0218 100 µM -0.967791398953539 0.190265124900531 no 2729 0.166574280111085 4085 295161
SGTC_3334 9142812 21.919 µM -0.969223834591725 0.189873073293745 no 2730 0.166216760764323 4057 45283678
SGTC_1976 st070609 63.5 µM -0.970047851581672 0.189647768523845 no 2731 0.166011320402939 3961 682556
SGTC_2090 5301565 104.445 µM -0.970168382474373 0.189614826460625 no 2732 0.165981283921873 4063 2056344
SGTC_2139 5578692 56.4705 µM -0.970772239915111 0.189449840362325 no 2733 0.16583085460805 4013 650991 YMR113W FOL3
SGTC_2918 7977171 22.06 µM -0.971415862585235 0.189274086893151 no 2734 0.165670616276989 4012 2236483
SGTC_2543 pimpinellin 60.67 µM -0.9726946035461 0.18892520018794 no 2735 0.165352554057157 3888 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_421 streptovitacin 30 mM -0.977816550110045 0.18753172421457 no 2736 0.164082532025135 4141 91467 include heat shock
SGTC_1725 st036284 20.55 µM -0.979361926370016 0.187112539808609 no 2737 0.163700591192727 4162 707914
SGTC_3340 9146634 11.102 µM -0.980171171795961 0.186893262797006 no 2738 0.163500816047358 4095 4907387
SGTC_2018 5133068 143 µM -0.980560996434161 0.186787690821115 no 2739 0.163404638144672 4030 785362
SGTC_1454 4239-0054 42.6 µM -0.981020841899087 0.186663203326612 no 2740 0.163291231890622 4182 1340767
SGTC_3257 9139206 32.98 µM -0.981403615176277 0.186559619684414 no 2741 0.163196872047104 4066 4910041
SGTC_1765 st044815 90.4 µM -0.981599636376086 0.186506587472571 no 2742 0.163148563352271 4110 645695
SGTC_1757 st041620 31.8375 µM -0.98254402946999 0.186251219164849 no 2743 0.162915951448572 4134 5289815
SGTC_67 0335-0847 266 µM -0.983624909552204 0.185959210177877 no 2744 0.162649986425672 4218 4552207 YOR254C SEC63
SGTC_1905 st060207 84.5 µM -0.985608923762307 0.185423951022746 no 2745 0.162162528648541 4027 1948547
SGTC_2103 5378138 10 µM -0.986626152366716 0.185149888295127 no 2746 0.161912972303867 4138 244142
SGTC_1267 0828-0272 9.49 µM -0.988288537182958 0.184702548835204 no 2747 0.161505678848285 4166 745334
SGTC_2038 4100038 30.985 µM -0.989754462228646 0.184308633750257 no 2748 0.161147073866251 4070 3596803
SGTC_621 3584-0052 32.1 µM -0.989999199912228 0.184242920182009 no 2749 0.16108725504464 4087 2273927
SGTC_2553 4-methylesculetin 85.09 µM -0.990162513493963 0.18419907759642 no 2750 0.161047345975997 4108 5319502
SGTC_831 k061-1017 217 µM -0.991381690053178 0.183871986977864 no 2751 0.160749618741992 4111 1240153
SGTC_442 cape 100 µM -0.991752504936512 0.183772573529303 no 2752 0.160659135760464 4049 5281787
SGTC_2813 7971799 71.43 µM -0.991794688332405 0.183761266512357 no 2753 0.160648844647388 4126 2234054
SGTC_1476 4112-3294 3.34 µM -0.992766594446696 0.183500872693908 no 2754 0.160411856473635 4096 704369
SGTC_746 1095-0025 46.6 µM -0.995526220478375 0.182762766044544 no 2755 0.159740199081677 4090 6749286
SGTC_1146 3579-1023 7 µM -0.995722800850339 0.182710258253583 no 2756 0.15969242426041 4119 X1146
SGTC_1500 4488-1866 171 µM -0.997586854075309 0.182212826705113 no 2757 0.159239869129365 4139 2900003
SGTC_1047 2043-3044 82 µM -0.998125157682445 0.182069335459693 no 2758 0.159109336152773 4093 669592
SGTC_1487 3970-0795 2.82 µM -0.998203365116671 0.182048494214531 no 2759 0.159090377503939 4126 3765103
SGTC_2587 piperic acid 92.2 µM -0.998577010219078 0.181948943331922 no 2760 0.158999820782897 4086 5370536
SGTC_2155 5570423 76 µM -0.999245719187106 0.181770863097205 no 2761 0.158837836639594 4031 797402
SGTC_1292 0kpi-0043 232 µM -1.000970800184 0.181311969866378 no 2762 0.158420462730572 4106 3333905
SGTC_245 methotrexate 289.6 µM -1.00176159236528 0.181101851917521 no 2763 0.158229375593032 4067 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.00279279672516 0.180828084355905 no 2764 0.15798042253438 4144 5377381
SGTC_75 0159-0059 199.013 µM -1.00281375202869 0.180822523762946 no 2765 0.157975366178562 4202 5377270
SGTC_973 1325-0077 65.9 µM -1.00296810479989 0.180781568797657 no 2766 0.157938125299241 4104 2835149
SGTC_2938 9059746 27.26 µM -1.00439728102207 0.180402636661481 no 2767 0.15759358003179 4089 6471769
SGTC_2098 5376439 882.5 nM -1.0056512185537 0.180070578081858 no 2768 0.157291688284394 4139 2844116
SGTC_2902 5787006 60.46 µM -1.00593109106623 0.179996516701048 no 2769 0.157224359507916 4052 591003
SGTC_1810 st050138 53 µM -1.00636534349829 0.179881640338356 no 2770 0.157119929156555 4103 3444541
SGTC_2679 rapamycin 1 nM -1.00691181386437 0.179737143494256 no 2771 0.156988577131385 4027 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1510 1123-0200 71.5 µM -1.00968638562806 0.179004621095964 no 2772 0.156322783586545 4161 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_586 0957-0265 8.15 µM -1.01021988161034 0.17886398696383 no 2773 0.156194977988928 3982 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_959 1222-0044 107 µM -1.01127539080327 0.17858595062528 no 2774 0.155942320530384 4103 6083612
SGTC_171 k064-0041 9.68 µM -1.01155199788616 0.17851313336684 no 2775 0.155876153608926 4124 53325
SGTC_3188 9110789 49.47 µM -1.01238135566212 0.17829491572068 no 2776 0.155677874668877 4093 849217
SGTC_1062 mesoridazine 14.2 µM -1.01255157211705 0.178250149776069 no 2777 0.155637200704657 4115 4078 A neuroleptic.
SGTC_2189 6047310 154.431 µM -1.01346257575247 0.178010681503491 no 2778 0.155419631563667 4082 711535
SGTC_773 4358-1457 44.6 µM -1.01372970034791 0.177940503065695 no 2779 0.155355873982294 4102 1186886
SGTC_1158 4092-0494 91.8 µM -1.01560041873575 0.177449520741268 no 2780 0.154909852694985 4200 1148199
SGTC_1656 st012921 11 µM -1.015793387813 0.177398923443452 no 2781 0.154863892701018 4016 6732821
SGTC_1087 pterostilbene 9.05 µM -1.01716249649909 0.177040199035242 no 2782 0.154538066869665 4157 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2250 alverine citrate 130 µM -1.01900733314479 0.176557553074415 no 2783 0.154099742573455 3996 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1694 st024011 44.9 µM -1.01988459929922 0.17632833501893 no 2784 0.153891597176737 4124 2787533
SGTC_2980 9014342 25.29 µM -1.01998748226917 0.176301465399764 no 2785 0.15386719874563 4175 2996599
SGTC_1042 0350-0096 82 µM -1.02131257652658 0.17595562633962 no 2786 0.153553184892827 4096 3122515
SGTC_158 k038-0087 26.446 µM -1.02390669750231 0.175279826079901 no 2787 0.152939673247781 4029 X158
SGTC_3214 9129694 49.47 µM -1.02536252110599 0.174901288213575 no 2788 0.152596082761968 4169 17158655
SGTC_1308 1187-1617 41.4 µM -1.02766921336052 0.174302573725665 no 2789 0.152052727198445 4125 2882570
SGTC_3098 9119039 49.47 µM -1.02780349994229 0.174267759073338 no 2790 0.152021134796606 4114 17161528
SGTC_188 3229-0966 278.469 µM -1.02833918698657 0.174128922767379 no 2791 0.151895151889256 4167 5722370
SGTC_1074 carmofur 3.8 µM -1.02851187405354 0.174084181709589 no 2792 0.15185455412384 4160 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_123 0083-0120 66.675 µM -1.02954355979433 0.173817037108905 no 2793 0.151612160770591 4088 16001701
SGTC_2040 5100729 123 µM -1.03009154668053 0.173675247525574 no 2794 0.151483516535433 4145 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_70 0141-0289 43.283 µM -1.03210052767455 0.173156060739307 no 2795 0.151012513347312 4106 352408
SGTC_2284 7945075 39.21 µM -1.03283061661569 0.172967626879677 no 2796 0.150841586571473 4127 1245402
SGTC_1362 1611-0397 101 µM -1.03494633739161 0.172422303648755 no 2797 0.150346986443398 4097 27816
SGTC_1826 st055655 41.6 µM -1.03605412962855 0.172137210094486 no 2798 0.150088445145326 4151 676168
SGTC_624 k048-0052 28 µM -1.03753414434832 0.171756793753305 no 2799 0.149743495743505 4113 6835531
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.04003894947194 0.171114194317007 no 2800 0.149160902668565 3960 88881 An O-methylated flavonoid and antioxidant.
SGTC_2164 5685496 200 µM -1.04137156537929 0.170772943580228 no 2801 0.148851567030831 4063 759046
SGTC_786 4544-0069 423 µM -1.04176824734716 0.170671447092563 no 2802 0.14875956943876 4136 748821 YLR208W SEC13
SGTC_581 0958-0271 211 µM -1.04293911310876 0.170372090381734 no 2803 0.148488246546569 4130 4591145
SGTC_2945 9067681 61.76 µM -1.04610673450175 0.169563907522665 no 2804 0.147755878142444 4210 16456930
SGTC_793 0488-0545 106 µM -1.04643349095389 0.16948067947369 no 2805 0.147680468436593 4159 292548
SGTC_1607 st000305 50.6 µM -1.04662264149512 0.169432512970826 no 2806 0.147636827562837 4156 5457690
SGTC_2133 5320837 200 µM -1.04689530904657 0.169363094623528 no 2807 0.147573932819793 4186 2841355
SGTC_2649 anisomycin 9.56 µM -1.0515589896028 0.168178596661579 no 2808 0.146500965819986 4162 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1470 k295-0292 231 µM -1.0516158466091 0.168164188882845 no 2809 0.146487917193576 4229 5045612
SGTC_22 0964-0034 14.468 µM -1.05421588644355 0.167506177618942 no 2810 0.145892044149405 4155 138402
SGTC_3141 9094609 49.47 µM -1.05531290252751 0.167229045919645 no 2811 0.145641121021114 4104 25236309 YDL196W YDL196W
SGTC_3277 9138724 49.47 µM -1.05659426518654 0.166905718446391 no 2812 0.145348399459055 4111 15943418
SGTC_682 0kpi-0099 17 µM -1.05829888717008 0.166476214989891 no 2813 0.144959600068544 4174 1714895 YML126C ERG13
SGTC_1224 0823-0416 294 µM -1.06039342508831 0.165949444651496 no 2814 0.144482826063892 4222 3598164
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.06077958353405 0.165852444633392 no 2815 0.144395041351455 4185 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1774 st048371 48.465 µM -1.06229757510507 0.165471492158066 no 2816 0.1440503074544 4140 4242727
SGTC_2059 5238311 157 µM -1.06276692037851 0.165353820752204 no 2817 0.143943832182704 4138 703021
SGTC_1329 1447-1697 50.6 µM -1.0631270711183 0.165263562661768 no 2818 0.143862164695024 4163 2840515
SGTC_281 1672-3440 14.9 µM -1.06375682683247 0.165105814967713 no 2819 0.143719436930899 4198 6833000
SGTC_1527 coumarin 137 µM -1.06423785752098 0.164985387133953 no 2820 0.143610480578478 4237 323 A hepatotoxic, DNA x-linker.
SGTC_666 0272-0154 136 µM -1.06491427976473 0.164816138542011 no 2821 0.143457361200046 4165 6870312
SGTC_2379 9035213 200 µM -1.06653497613484 0.164411079450322 no 2822 0.143090938280458 4163 646551
SGTC_3338 9144300 39.5675 µM -1.07174367124238 0.163113649069959 no 2823 0.141917589874349 4161 4901274
SGTC_3194 9111903 49.47 µM -1.0728158521069 0.162847408360239 no 2824 0.141676873450868 4209 17087251
SGTC_339 3091-4833 71.4 µM -1.07365001572403 0.162640466937628 no 2825 0.141489785922645 4031 3240077
SGTC_1996 st072960 66.8 µM -1.07417968813718 0.162509153305957 no 2826 0.141371077098229 4200 1719405
SGTC_1315 1237-0019 3.69 µM -1.07458466580608 0.162408799899037 no 2827 0.141280360089776 4181 825140
SGTC_987 1497-1013 404 µM -1.07582052349244 0.162102803947939 no 2828 0.141003765832312 4177 1676435
SGTC_2129 girgensonine 121.053 µM -1.07788456272249 0.161592589586656 no 2829 0.140542637709267 4181 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2002 4023503 131 µM -1.07982308958741 0.161114355261833 no 2830 0.140110483574096 4179 4736863 YCR052W RSC6
SGTC_816 0325-0417 81.3 µM -1.07985610744232 0.161106217768364 no 2831 0.140103130759629 4193 68101
SGTC_111 0083-0039 52.457 µM -1.08173711547747 0.160643072346887 no 2832 0.139684678028621 4045 759313
SGTC_1211 1056-0033 32.3 µM -1.08293806802662 0.160347826787497 no 2833 0.139417956684698 4223 6741922
SGTC_2611 pyromycin 23.93 µM -1.08382604901221 0.160129751216959 no 2834 0.139220966587337 4145 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_404 fumagillin 50 µM -1.08610280323058 0.15957149893516 no 2835 0.138716756146973 4176 12015870 A methionine aminopeptidase binder.
SGTC_968 1309-0633 340 µM -1.08645467655404 0.159485334591796 no 2836 0.138638941323067 4217 3761976
SGTC_215 1287-0124 461.5 µM -1.08776821116424 0.159163954287687 no 2837 0.1383487231989 4202 5560863
SGTC_1277 0873-0036 22 µM -1.08966923314337 0.158699586186318 no 2838 0.137929436818868 4253 5965735
SGTC_2644 guaiazulene 100 µM -1.09053618919944 0.158488107545924 no 2839 0.13773851045911 4193 3515 A coloring agent.
SGTC_101 0490-5701 117.494 µM -1.09438678989762 0.157551056069245 no 2840 0.136892687580907 3965 4661669
SGTC_71 0417-1750 47.813 µM -1.09491515358991 0.157422762314859 no 2841 0.136776904789046 4191 6811472
SGTC_845 0330-0138 4.51 µM -1.09503280658006 0.157394203948825 no 2842 0.136751132058203 4146 9039800
SGTC_1829 berberine 14.4 µM -1.09518169976205 0.157358067412062 no 2843 0.136718520699033 4171 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3187 9109394 49.47 µM -1.09624527314491 0.157100095630098 no 2844 0.136485725966834 4194 17098090
SGTC_1046 2001-0062 216 µM -1.09961465114964 0.156284683801879 no 2845 0.135750027825112 4107 739778
SGTC_944 3370-0224 231 µM -1.10213508460716 0.155676548195097 no 2846 0.13520147424585 4223 4580514
SGTC_1471 k673-0312 37 µM -1.10256134876821 0.155573852758913 no 2847 0.135108851483657 4148 24099884
SGTC_1462 k081-0014 26.5 µM -1.10815647686746 0.154230019776539 no 2848 0.133897121799536 3743 3270634
SGTC_1077 5-fluorocytosine 377 nM -1.11082396345403 0.153592055700528 no 2849 0.133322064771165 4262 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1911 st060208 74.3 µM -1.11185017219252 0.15334709064821 no 2850 0.133101287826469 4240 688783
SGTC_2076 5212012 200 µM -1.11241873525581 0.153211481133612 no 2851 0.13297907644448 4166 604802
SGTC_2963 9082507 9 µM -1.11252850314443 0.1531853092526 no 2852 0.13295549097734 4241 16459611
SGTC_2450 5739737 12.93 µM -1.11281936023962 0.153115974725636 no 2853 0.132893009391097 4231 2262825
SGTC_2237 6667747 47.222 µM -1.11381362729824 0.152879118402025 no 2854 0.132679574780923 4209 729940 YDL015C TSC13
SGTC_1526 st051518 75 µM -1.1140068832931 0.152833108781356 no 2855 0.132638116852212 4198 673993
SGTC_1278 0874-0585 172 µM -1.11581368878894 0.152403395973319 no 2856 0.132250946542725 4287 766306
SGTC_1944 st076371 56.9 µM -1.1228208101808 0.150744482986532 no 2857 0.130756802635923 4179 24208455
SGTC_14 0354-0009 295 µM -1.1245294841963 0.150341790252926 no 2858 0.130394234832871 4301 1713507
SGTC_2497 7-hydroxyflavone 100 µM -1.12528965736698 0.15016286660185 no 2859 0.13023315550466 4238 5281894
SGTC_2376 9072922 81.32 µM -1.13042117221377 0.148958764663163 no 2860 0.129149398454618 4233 17087968
SGTC_3197 9113331 49.47 µM -1.13108416414722 0.14880366651479 no 2861 0.129009834423976 4243 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_336 4111-0029 111 µM -1.13615067744153 0.147621987585484 no 2862 0.127946754364458 4232 3131175
SGTC_1832 st054113 55 µM -1.13618806471063 0.147613291061864 no 2863 0.127938932278269 4237 1251267
SGTC_195 4234-0266 16.654 µM -1.13871784267693 0.147025645282113 no 2864 0.127410429135582 4233 2303354
SGTC_789 1309-1135 70.6 µM -1.14079197131278 0.146545014861245 no 2865 0.126978251236751 4209 3092424
SGTC_2046 4110841 106 µM -1.14083161749404 0.146535838076481 no 2866 0.126970000270425 4223 44119630 YMR134W ERG29
SGTC_1798 st045719 60.953 µM -1.14209745413871 0.146243041351573 no 2867 0.126706756784603 4165 3980186
SGTC_1114 scopoletin 1.73284 µM -1.1441793175083 0.145762347034318 no 2868 0.126274639320018 4265 5280460 A coumarin with genotoxic properties.
SGTC_640 3381-0960 37.1 µM -1.14557016239018 0.145441798691089 no 2869 0.125986524501264 4302 1745025
SGTC_1650 st011916 45.8 µM -1.14592339533535 0.145360464567207 no 2870 0.12591342501284 4163 242528
SGTC_778 3456-2434 196 µM -1.14606809258095 0.145327155945122 no 2871 0.125883489307015 4192 5539063
SGTC_2724 maprotiline 69.64 µM -1.14772888957387 0.144945216018579 no 2872 0.125540250542665 4165 4011 A tricyclic antidepressant.
SGTC_980 1473-0395 201 µM -1.15382450143586 0.143549180367398 no 2873 0.124286063468775 4125 768876
SGTC_1452 4194-0072 190 µM -1.15468689854327 0.143352406876704 no 2874 0.124109333279949 4308 1343545
SGTC_2373 9071805 200 µM -1.15519643745022 0.143236230819832 no 2875 0.124004996644095 4271 10149009
SGTC_53 0973-0023 39.979 µM -1.1561348783409 0.143022430561542 no 2876 0.12381299579508 4135 674768
SGTC_3225 9130819 49.47 µM -1.15651452974947 0.142935997787339 no 2877 0.123735379953995 4191 4547121
SGTC_2618 avocadyne 43.43 µM -1.15712798364543 0.142796411330744 no 2878 0.123610037593889 4167 3015189
SGTC_1094 duloxetine 25.4 µM -1.15951083443317 0.142255087265892 no 2879 0.123124011418733 4257 60834 A selective serotonin reuptake inhibitor.
SGTC_392 N-ethylmaleimide 8.33 µM -1.16115895369291 0.141881489178628 no 2880 0.122788631811233 4188 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_771 0250-0039 27.3 µM -1.16166243777303 0.141767491269984 no 2881 0.122686304545808 4210 3005115
SGTC_1463 k081-0032 34.1 µM -1.16321694457817 0.141415914315057 no 2882 0.122370746674785 3852 977755
SGTC_1651 st011928 86.1 µM -1.16374568754577 0.141296465295975 no 2883 0.12226354418063 4268 720198
SGTC_1466 k213-0079 57.5 µM -1.16461355695613 0.141100552074233 no 2884 0.122087726836979 4186 3657981
SGTC_2404 5161160 200 µM -1.16671747541019 0.140626377450484 no 2885 0.121662241579162 4200 2831543
SGTC_1512 0259-0544 12.2 µM -1.17107727103744 0.1396472262495 no 2886 0.120783859487483 4236 18476
SGTC_1422 4031-0024 15.5 µM -1.17108316364786 0.139645905993563 no 2887 0.120782675312727 4184 782427
SGTC_2207 7258803 200 µM -1.17114026468384 0.139633112785468 no 2888 0.120771200752818 4253 3666799
SGTC_3259 9138485 49.47 µM -1.17206719928732 0.139425549088321 no 2889 0.120585038830629 4271 17646153
SGTC_2715 st079500 56.4 µM -1.17267350394533 0.139289896002577 no 2890 0.120463380329629 4234 28246688
SGTC_2081 5214970 32.255 µM -1.17267405502452 0.139289772746363 no 2891 0.12046326979177 4216 2063512
SGTC_406 estrone 100 µM -1.17358916465941 0.139085198641833 no 2892 0.120279811661129 4249 5870 A steroid.
SGTC_1203 3992-3522 103 µM -1.174816490405 0.138811149393774 no 2893 0.1200340706352 4378 5322312
SGTC_1070 indatraline 8.81 µM -1.17614092687121 0.138515829111838 no 2894 0.119769282838802 4302 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_646 4092-0839 27.3 µM -1.17766426085048 0.13817668878762 no 2895 0.119465240104295 4286 877796
SGTC_366 0181-0206 4.31 µM -1.17785941076254 0.13813328344629 no 2896 0.119426329452451 4288 274874
SGTC_2967 9089538 49.85 µM -1.17796276208376 0.138110299759802 no 2897 0.119405726007897 4270 728216
SGTC_3143 9086658 49.47 µM -1.17933446491222 0.137805501899318 no 2898 0.119132509812106 4307 25236626
SGTC_1085 doxorubicin 7.67 µM -1.18125855610683 0.137378735062562 no 2899 0.118750012881138 4291 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1568 digitonin 820 nM -1.18372154928063 0.136833757092812 no 2900 0.118261652884593 4260 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3212 9128307 49.47 µM -1.1843033989037 0.136705229322064 no 2901 0.118146491931979 4188 27243542
SGTC_2924 9010168 62.78 µM -1.18434080126285 0.136696970146014 no 2902 0.118139091888841 4314 2993929
SGTC_127 0180-0333 59.125 µM -1.18500596687528 0.136550145487435 no 2903 0.118007543861525 4187 771601
SGTC_647 0140-0236 81 µM -1.1856186421999 0.136415002673875 no 2904 0.117886468401325 4282 990837
SGTC_1938 st074717 56.4 µM -1.18638088890811 0.136246995439176 no 2905 0.117735957724801 4158 17250979
SGTC_1655 st012546 55.1 µM -1.18887121731517 0.135699087942733 no 2906 0.117245173965029 4259 720985 YLR208W SEC13
SGTC_1746 st038117 42 µM -1.19349011967448 0.134686864160812 no 2907 0.116338739694985 4324 2898218
SGTC_1883 5-benzylidenerhodanine 20 µM -1.19407874776209 0.134558240640762 no 2908 0.116223582813004 4258 1273210
SGTC_2287 7945887 168.79 µM -1.1964060522809 0.134050517711624 no 2909 0.115769070327489 4296 1245853
SGTC_18 0111-0177 500 nM -1.19775439635507 0.133756966977504 no 2910 0.11550632283282 4355 721752
SGTC_2104 5389443 200 µM -1.19916319175137 0.133450727654675 no 2911 0.115232248309667 4306 2244536
SGTC_1821 st053465 65.6 µM -1.20214025450291 0.132805170833223 no 2912 0.114654596206795 4300 675086
SGTC_396 dithiazanine 1.25 µM -1.20504118266767 0.132178195163729 no 2913 0.114093701983903 4265 10578 An antihelmenthic.
SGTC_2272 7805186 180 µM -1.20786643951951 0.131569538735779 no 2914 0.113549320216194 4312 2956062 YPR165W RHO1
SGTC_3233 9132340 49.47 µM -1.20834957665522 0.131465648563963 no 2915 0.113456413166297 4294 17682950
SGTC_1630 st005209 31.3 µM -1.21055531215163 0.130992063358125 no 2916 0.113032939960462 4283 3367314
SGTC_1365 1672-3266 55.4 µM -1.21216845993855 0.130646457580215 no 2917 0.112723951044891 4311 6415873
SGTC_2481 5478948 45.16 µM -1.21353500980611 0.130354177348909 no 2918 0.112462668770063 4315 77792
SGTC_3226 9131256 49.47 µM -1.21442168774075 0.13016477515445 no 2919 0.112293368888775 4250 17178073
SGTC_2492 derrusnin 100 µM -1.2153699018274 0.12996243910743 no 2920 0.11211252107041 4319 1715307 Part of coumarin class of compounds.
SGTC_1228 0124-0032 52.5 µM -1.21592215516098 0.129844696105796 no 2921 0.112007288725075 4359 X1228
SGTC_2989 9073649 71.4286 µM -1.21615799049305 0.129794437418602 no 2922 0.111962371625705 4276 21367202
SGTC_411 enrofloxacin 100 µM -1.21843480487871 0.129309920006288 no 2923 0.111529392786488 4364 71188 A bacterial gyrase inhibitor.
SGTC_2799 7812892 81.82 µM -1.21981512307065 0.129016792527256 no 2924 0.111267483556856 4323 20205235
SGTC_1143 3454-2408 5.08 µM -1.22000054577308 0.128977450878917 no 2925 0.111232334000315 4301 X1143
SGTC_381 3461-2219 42.7 µM -1.22166964758528 0.128623687419784 no 2926 0.110916289419932 4298 2883159
SGTC_363 0455-0021 3.06 µM -1.22232802096825 0.128484331586267 no 2927 0.110791803437093 4270 4597466
SGTC_2750 bromebric acid 70.15 µM -1.22464832325161 0.127994036137797 no 2928 0.110353876241985 4320 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1023 4482-3888 16 µM -1.22491078452718 0.127938658249005 no 2929 0.110304418305519 4331 3303168
SGTC_2966 9084041 48.03 µM -1.22610029482909 0.127687886809253 no 2930 0.110080467463411 4225 17741380
SGTC_888 0916-0002 6.97 µM -1.22718022677417 0.127460512668981 no 2931 0.109877429772579 4344 2802138 YIL048W NEO1
SGTC_1142 3253-1408 9.78 µM -1.22804693194088 0.12727823611011 no 2932 0.109714675295436 4329 256655
SGTC_510 ag-490 170 µM -1.23034493279948 0.126795822137033 no 2933 0.109283982488447 4441 5328779
SGTC_423 5-fluorouracil 457 µM -1.23048581779754 0.126766287949899 no 2934 0.109257617302908 4240 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_928 2764-0428 58.7 µM -1.23138313474074 0.126578292847377 no 2935 0.10908980086036 4328 662578
SGTC_2684 capsaicin 100 µM -1.23181348037788 0.126488200914532 no 2936 0.109009383267548 4342 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1852 st056254 31.4 µM -1.23671141548249 0.125465975581838 no 2937 0.108097119576824 4262 442583
SGTC_1571 st070080 73.4 µM -1.24031100767187 0.124718406597511 no 2938 0.107430191251578 4328 4315245
SGTC_1052 3253-3998 198 µM -1.24105971067808 0.124563306671263 no 2939 0.107291845806347 4264 5450317
SGTC_1689 st020265 53.493 µM -1.24400453325697 0.123954571083759 no 2940 0.106748947253305 4335 5758320 YPR016C TIF6
SGTC_821 1114-0266 29.2 µM -1.24517767617725 0.123712647060224 no 2941 0.106533223283644 4344 3123235
SGTC_1436 4092-1007 8.32 µM -1.24890163142045 0.122946888812914 no 2942 0.105850527424955 4309 2881121
SGTC_2041 5107442 45.335 µM -1.24997449999518 0.122726892401714 no 2943 0.105654431293643 4362 793005
SGTC_3252 9135871 49.47 µM -1.25278696217753 0.12215149575606 no 2944 0.105141623867838 4337 17682838
SGTC_842 0271-0008 11.1 µM -1.25337446063187 0.122031540039311 no 2945 0.105034730747976 4363 1221709
SGTC_1975 st070967 30.8 µM -1.25670394920791 0.121353286404309 no 2946 0.104430428780044 4319 261391
SGTC_1692 fluoroquinolonic acid 71 µM -1.25698571029465 0.121296010444077 no 2947 0.1043794050149 4338 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.2577852299924 0.12113358882202 no 2948 0.104234719352814 4307 6857784
SGTC_1089 terbinafine 2.25 µM -1.25788885424588 0.121112548863572 no 2949 0.104215977561421 4342 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1017 4239-0030 168 µM -1.26019305106862 0.12064536673495 no 2950 0.103799864510352 4353 1149593
SGTC_3182 9108849 49.47 µM -1.26077594073189 0.120527385621342 no 2951 0.103694792197751 4353 17133045
SGTC_1491 4138-0063 26.5 µM -1.26215306760376 0.120248967900648 no 2952 0.103446856408879 4326 23883227
SGTC_524 r073-0010 27.8 µM -1.26437549722628 0.119800609117492 no 2953 0.103047641629285 4260 2772106
SGTC_3296 9122258 64.045 µM -1.26613763002564 0.119445950616317 no 2954 0.102731906194625 4317 4730474
SGTC_1747 st037496 66.6 µM -1.26789610942151 0.119092766546738 no 2955 0.102417526835841 4304 723305
SGTC_2396 5342950 42.78 µM -1.26925682130089 0.118819979056281 no 2956 0.102174740526246 4318 1886677
SGTC_654 1124-0271 80.9 µM -1.27159686858404 0.118351892886386 no 2957 0.101758194968767 4325 5403748
SGTC_1496 4469-0713 57.4 µM -1.2723156093689 0.118208383206029 no 2958 0.10163050235586 4320 746691
SGTC_558 k064-0027 21.3 µM -1.27322013695933 0.118027952736747 no 2959 0.101469968434811 4347 5088526
SGTC_2220 6782180 200 µM -1.27350011256103 0.117972144157999 no 2960 0.101420316322793 4271 833803
SGTC_1756 st041558 35.5 µM -1.27487931977603 0.117697494140133 no 2961 0.101175979930925 4428 3955792
SGTC_2009 4012297 12.05 µM -1.28022557142217 0.1166371402008 no 2962 0.100232907525723 4323 45595307
SGTC_1387 3342-1166 1.8 µM -1.28200834760463 0.116285062243788 no 2963 0.0999198589723522 4320 3418228
SGTC_852 0418-0143 439 µM -1.28344747546415 0.116001401478525 no 2964 0.0996676750603278 4342 5369229
SGTC_2907 7721985 69.9 µM -1.28457020022141 0.115780447019984 no 2965 0.0994712588397922 4358 3267881
SGTC_2073 5212005 126 µM -1.28469877141287 0.115755163041467 no 2966 0.0994487838897797 4245 691789
SGTC_2878 9043973 25.97 µM -1.28565899128338 0.115566456418012 no 2967 0.0992810495522914 4376 6465167
SGTC_23 0213-0011 39.996 µM -1.28802439115793 0.115102530284021 no 2968 0.0988687363676925 4355 627608
SGTC_46 0329-0187a 2.197 µM -1.29243070743343 0.114241853221585 no 2969 0.0981040140781359 4391 46494817
SGTC_1300 1094-0077 113 µM -1.29524220156601 0.113695090358031 no 2970 0.0976183454073351 4322 5532636
SGTC_1314 1222-0010 41.1 µM -1.29718056871947 0.113319216071455 no 2971 0.0972845324527261 4373 3526027
SGTC_784 4579-0127 173 µM -1.29769896155595 0.113218843436391 no 2972 0.097195400326892 4388 1948547
SGTC_3294 9122953 26.2835 µM -1.29822750223861 0.113116571266702 no 2973 0.0971045850990539 4332 16459826
SGTC_1819 st053448 58.6 µM -1.29844180241328 0.113075123154739 no 2974 0.0970677812383181 4274 2857616
SGTC_2563 tomatine 8.54 µM -1.30028347587335 0.112719369124205 no 2975 0.0967519146749736 4330 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1007 4101-0031 70 µM -1.30194821738582 0.112398481220707 no 2976 0.0964670439541455 4356 1146276
SGTC_2721 ifenprodil 61.44 µM -1.30256756364511 0.112279265625446 no 2977 0.0963612188074663 4366 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1953 st076800 12.1 µM -1.30272729901727 0.112248533437097 no 2978 0.0963339393260168 4354 297591
SGTC_1706 st031321 9.9705 µM -1.30563679185011 0.111689815028423 no 2979 0.0958380511890788 4384 6103185
SGTC_3010 9080089 71.4286 µM -1.30655084105675 0.111514698864974 no 2980 0.0956826507335484 4383 17027233
SGTC_214 4373-3496 70 µM -1.30783208283256 0.11126956574822 no 2981 0.0954651348707733 4467 3779166
SGTC_1531 st059297 52.4 µM -1.30854158194104 0.111133987164876 no 2982 0.0953448401993937 4392 7566702
SGTC_2947 9072639 7.68 µM -1.30923208142285 0.111002152855722 no 2983 0.0952278740777484 4343 16488146
SGTC_3311 9131146 2.8755 µM -1.30976456799657 0.110900563844498 no 2984 0.0951377464972515 4322 4900406 YPR165W RHO1
SGTC_340 k038-0059 454 µM -1.31306772953362 0.110271866991616 no 2985 0.0945800633488078 4329 23733424
SGTC_2541 muurolladie-3-one 83.07 µM -1.31454367449552 0.109991775412625 no 2986 0.0943316553534041 4321 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3003 9075612 71.4286 µM -1.31456257755257 0.109988191474059 no 2987 0.0943284770098575 4395 6501993
SGTC_2297 7971671 152.32 µM -1.31458940747323 0.109983104780007 no 2988 0.0943239659859686 4366 909016
SGTC_527 4476-4215 268 µM -1.31725540560928 0.109478498683776 no 2989 0.0938765138402591 4383 4418754
SGTC_2997 9067075 71.4286 µM -1.31784749779105 0.109366656587538 no 2990 0.0937773520363582 4338 27209819
SGTC_1597 7-benzyloxygramine 47.5 µM -1.31840138722903 0.109262105045982 no 2991 0.0936846583325998 4280 260807
SGTC_1380 2291-0730 164 µM -1.31977151250278 0.109003790309198 no 2992 0.093455657772614 4387 2999191
SGTC_1764 st044502 93.5 µM -1.32016147625019 0.108930349327469 no 2993 0.0933905554987239 4397 8407
SGTC_2064 5220758 200 µM -1.3206458662076 0.108839174814512 no 2994 0.0933097359540333 4419 788518
SGTC_3299 9121982 43.1275 µM -1.3219124766848 0.108601025847254 no 2995 0.0930986486337313 4397 17594604 YPL160W CDC60
SGTC_338 4055-0136 114 µM -1.3238578534736 0.108235985075075 no 2996 0.0927751289481029 4365 2900563
SGTC_1922 5578187 25 µM -1.32464276873641 0.108088949758042 no 2997 0.0926448317722902 4392 1350412
SGTC_725 1497-0963 19 µM -1.32632839804752 0.10777367309265 no 2998 0.0923654721859302 4485 3549977
SGTC_1346 1488-2224 62.4 µM -1.32778015747077 0.107502670368734 no 2999 0.0921253719464215 4405 3722427
SGTC_3345 9148410 3.559 µM -1.32807395726671 0.107447885998917 no 3000 0.0920768379308615 4330 4903596
SGTC_360 0957-0399 1.01 µM -1.33412636803086 0.106323776705161 no 3001 0.0910812227996969 4405 6752301 YPR165W RHO1
SGTC_1759 st043059 70 µM -1.33813042529821 0.1055847894155 no 3002 0.0904269621048319 4394 669426
SGTC_3144 9087057 49.47 µM -1.33824893847377 0.1055629734038 no 3003 0.0904076504306022 4307 17249618
SGTC_2722 naftopidil 47.16 µM -1.33835413816925 0.105543610880602 no 3004 0.0903905107484445 4320 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_131 0141-0277 33.849 µM -1.34011359088707 0.105220155536894 no 3005 0.0901042090967778 4363 1547771
SGTC_554 4483-2211 187 µM -1.34066241514508 0.105119407364023 no 3006 0.0900150413175578 4453 747107
SGTC_1971 st069429 63.5 µM -1.3443698982957 0.104440649637907 no 3007 0.0894144013855969 4400 1246522 YGL099W LSG1
SGTC_201 4262-0159 12.803 µM -1.34589233401751 0.104162847225051 no 3008 0.0891686207371964 4443 1341029
SGTC_2077 5212015 200 µM -1.34732368727951 0.103902153765243 no 3009 0.0889380032169159 4310 780900
SGTC_2013 4024628 200 µM -1.35038365003802 0.103346428217303 no 3010 0.0884464763008463 4429 5230760
SGTC_1556 plumbagin 1.48 µM -1.35098837213794 0.103236859337402 no 3011 0.0883495787597776 4325 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2871 9038510 12.99 µM -1.35220177598895 0.10301725861225 no 3012 0.0881553878619544 4386 4945164
SGTC_2493 resveratrol 26.09 µM -1.35231615301414 0.102996576275043 no 3013 0.0881370995979343 4330 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2131 toluylene red 5.2905 µM -1.3582167671164 0.101933680055665 no 3014 0.0871974558598434 4373 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_143 4032-1194 15.74 µM -1.35847937154908 0.101886562525163 no 3015 0.0871558119318217 4439 1806963
SGTC_126 0417-1624 672.48 µM -1.35879588174139 0.101829794078206 no 3016 0.0871056393441964 4459 41912 YDL195W SEC31
SGTC_1327 1436-0082 2.18 µM -1.35911227580621 0.101773069473798 no 3017 0.0870555067262289 4424 15992205
SGTC_2112 5488546 200 µM -1.36035467268045 0.101550549272373 no 3018 0.0868588574699676 4376 600757
SGTC_828 2074-0507 139 µM -1.36209912460885 0.101238706535607 no 3019 0.0865833022774625 4467 X828
SGTC_954 1189-0853 2.85 µM -1.36216344747886 0.101227221366564 no 3020 0.0865731542850754 4330 2828194
SGTC_1515 3460-0031 42.1 µM -1.36352198608563 0.100984869271752 no 3021 0.0863590300799333 4382 2876596
SGTC_2783 7738165 71.43 µM -1.36595331145868 0.100552197208037 no 3022 0.0859768090464695 4392 17201110
SGTC_2676 harmalol 100 µM -1.36680552914241 0.100400859415714 no 3023 0.0858431346288079 4372 5459187 A monoamine oxidase inhibitor
SGTC_190 3970-0790 3.722 µM -1.36892690257751 0.100024865452178 no 3024 0.0855110626853732 4378 2832352
SGTC_2214 7179297 48.276 µM -1.36938160487775 0.0999444076278541 no 3025 0.0854400106352554 4487 769744
SGTC_2180 6301957 200 µM -1.37070190461596 0.0997110535509898 no 3026 0.0852339504289254 4437 845462
SGTC_1037 k284-1091 78.7 µM -1.37304961539675 0.0992970951764178 no 3027 0.0848684614536105 4387 3334711
SGTC_1173 0443-0020 122 µM -1.3778169142549 0.0984603737339581 no 3028 0.084129911217126 4413 5331295
SGTC_269 exalamide 29 µM -1.38050664907684 0.0979905751423794 no 3029 0.083715351921695 4368 3316 A derivative of salicylamide.
SGTC_2085 5307070 144.047 µM -1.38286011757961 0.0975808592743177 no 3030 0.0833538806139989 4366 2840351
SGTC_895 0964-0006 13.7 µM -1.38419230947938 0.0973494952250767 no 3031 0.0831497887814205 4413 6738897
SGTC_455 paf C-16 10 µM -1.38467482911577 0.0972657945705151 no 3032 0.0830759595355273 4391 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2586 curcumin 80 µM -1.38564034176413 0.0970984697091194 no 3033 0.0829283766525679 4323 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_889 0919-1524 82.7 µM -1.38776729569412 0.0967306107517543 no 3034 0.0826039582477204 4438 3905452
SGTC_2880 9042983 58.44 µM -1.388816179165 0.0965495825043307 no 3035 0.0824443270641803 4379 6464714
SGTC_3066 9117245 49.47 µM -1.39298922260037 0.0958318159604655 no 3036 0.0818115248771991 4472 17176980
SGTC_2911 7942208 15.64 µM -1.3931566718064 0.0958030967026732 no 3037 0.0817862094138793 4441 1243384
SGTC_674 0498-0004 451 µM -1.39817443185278 0.0949454343732322 no 3038 0.0810303463690602 4423 4231473
SGTC_689 0833-0039 98 µM -1.39943442182553 0.0947309614025824 no 3039 0.0808413753510224 4400 5374726
SGTC_2416 tofa 880 nM -1.3997712011206 0.0946736960229902 no 3040 0.0807909221970619 4383 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3312 9133330 71.43 µM -1.4040893862727 0.0939416987782559 no 3041 0.0801461168833916 4447 17617324
SGTC_380 3970-0968 6 µM -1.40530821591392 0.0937358466605607 no 3042 0.0799648231535084 4330 2891601
SGTC_534 k292-0788 63.4 µM -1.40592970642516 0.0936310093824482 no 3043 0.079872499553783 4480 4146317
SGTC_1367 1812-0510 76.9 µM -1.4059606814343 0.093625786571651 no 3044 0.0798679002669953 4494 1142582 YDR527W RBA50
SGTC_2823 7987624 58.44 µM -1.40788985388236 0.0933009254518509 no 3045 0.079581843959486 4401 2239440
SGTC_1896 st058441 89 µM -1.41226848606152 0.0925666814751679 no 3046 0.0789354609058995 4453 688759
SGTC_2391 6285546 200 µM -1.41342495589185 0.0923734708715095 no 3047 0.0787654060633766 4442 846083
SGTC_2177 5811945 192 µM -1.41699735734554 0.0917785172093824 no 3048 0.0782418500534399 4458 5343475
SGTC_1415 3966-0071 78.1 µM -1.4213645011212 0.0910550678102945 no 3049 0.0776054104697929 4350 2893185
SGTC_883 0850-0245 24.6 µM -1.42748740432142 0.0900478983430289 no 3050 0.0767197266105626 4502 6823229 YPR165W RHO1
SGTC_3191 9110352 49.47 µM -1.42975962723136 0.0896762490227816 no 3051 0.0763930100516765 4412 17122424
SGTC_599 1935-0052 86.5 µM -1.42999071377092 0.0896385160294763 no 3052 0.0763598421617181 4446 9557311
SGTC_3151 9099821 49.47 µM -1.43237741722851 0.0892494932382672 no 3053 0.0760179189491178 4392 17174189
SGTC_375 3970-0961 9.27 µM -1.43271962103602 0.0891938185577159 no 3054 0.0759689899460678 4422 2898222
SGTC_358 0075-0058 9.45 µM -1.43334915959241 0.089091463601019 no 3055 0.0758790398702646 4421 1069125
SGTC_1596 piperlongumine 63 µM -1.43438740213135 0.0889228495878657 no 3056 0.0757308703408719 4492 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_33 0986-0033 35.816 µM -1.43482308748509 0.0888521636568755 no 3057 0.0756687585594396 4427 2848082
SGTC_2786 7743617 45.45 µM -1.43550945377138 0.0887408919368952 no 3058 0.0755709881659966 4387 583674
SGTC_1548 st061468 90.8 µM -1.43734730319559 0.0884434560883488 no 3059 0.0753096671105081 4497 390799
SGTC_1057 3448-5381 134 µM -1.43752913715216 0.0884140686784938 no 3060 0.0752838499064414 4426 5497911
SGTC_2641 levomentholum 100 µM -1.43930950273434 0.0881267160943282 no 3061 0.0750314258231084 4460 16666
SGTC_651 3253-0966 34.4 µM -1.43950508599798 0.088095191274748 no 3062 0.075003735002324 4476 781462
SGTC_2520 obtusaquinone 4.71 µM -1.44352652784589 0.0874488630282623 no 3063 0.0744361025783726 4493 5967872
SGTC_1497 4476-2978 41.3 µM -1.44522299815476 0.087177269376531 no 3064 0.0741976292551581 4499 1528379
SGTC_1009 4106-0057 9.87 µM -1.44647171568958 0.0869777607704027 no 3065 0.0740224698266286 4464 2928005
SGTC_506 n9-isopropylolomoucine 153 µM -1.44749862702207 0.0868139460484624 no 3066 0.0738786603504302 4454 6610355
SGTC_2223 6903751 107.57 µM -1.44806548082643 0.0867236193270514 no 3067 0.0737993692041906 4447 5598863
SGTC_3116 9124943 49.47 µM -1.45008410834421 0.0864025264978992 no 3068 0.0735175330506692 4440 41905195 YPL160W CDC60
SGTC_2216 7189485 200 µM -1.4541746650763 0.0857545895510526 no 3069 0.0729489435567326 4479 731273
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.45616502113453 0.0854406392141175 no 3070 0.0726735032753618 4466 5282362
SGTC_2319 6033012 152.6 µM -1.45835319131559 0.0850964808420437 no 3071 0.0723716078815045 4422 847246
SGTC_1018 4259-0013 28.1 µM -1.45862138501481 0.0850543705467474 no 3072 0.0723346721888904 4509 6801262
SGTC_548 1436-0017 110 µM -1.45925915387605 0.0849542943306396 no 3073 0.0722468965446016 4498 9677137
SGTC_723 4182-0001 115 µM -1.46284825690546 0.0843927517171987 no 3074 0.0717544525643161 4479 744821 YLR208W SEC13
SGTC_1797 st048695 56.8 µM -1.46659197165003 0.0838099913814245 no 3075 0.0712435426540686 4427 592262 YIL048W NEO1
SGTC_2166 5933061 31.504 µM -1.46705364263464 0.0837383358517643 no 3076 0.0711807317062815 4514 2877375
SGTC_129 0088-0017 176.636 µM -1.47106544991084 0.0831176033530212 no 3077 0.0706367087857542 4337 182446
SGTC_761 k216-0224 480 µM -1.47130779659395 0.0830802170481799 no 3078 0.0706039478866024 4488 1340404
SGTC_1239 0337-0584 35.4 µM -1.47271183404566 0.0828638680342972 no 3079 0.0704143771237287 4533 914301 YML130C ERO1
SGTC_2537 larixol 68.93 µM -1.47276624432552 0.0828554924593639 no 3080 0.0704070386239477 4457 6708759
SGTC_2161 5662504 8.5105 µM -1.47338860182466 0.0827597359787088 no 3081 0.0703231409722682 4449 2859334
SGTC_2217 6934799 96.0675 µM -1.47410574958146 0.0826494982763493 no 3082 0.0702265603601116 4452 675606
SGTC_416 estradiol valerate 100 µM -1.47690078368895 0.0822209089752456 no 3083 0.0698511174233725 4478 13791 A steroid.
SGTC_2430 5571206 200 µM -1.47713713922953 0.0821847432252491 no 3084 0.0698194399388043 4451 1731771
SGTC_602 3130-1533 38.1 µM -1.47811280650919 0.0820355791068385 no 3085 0.0696887934182485 4528 720941
SGTC_1227 3909-8010 46.6 µM -1.48386121714364 0.0811608764592402 no 3086 0.0689228712707998 4472 15982272
SGTC_1196 1588-0294 184 µM -1.48742953915004 0.0806214565980654 no 3087 0.0684507000147068 4520 6144269
SGTC_1170 0310-0127 64.8 µM -1.48875904038558 0.08042117102719 no 3088 0.0682754158616887 4488 774975
SGTC_2364 9055074 200 µM -1.48935498686376 0.0803315155062023 no 3089 0.0681969575869715 4472 6470630
SGTC_740 k014-0057 261 µM -1.49555882387739 0.0794026773635826 no 3090 0.067384330041655 4480 4012779
SGTC_1499 4480-0877 67.3 µM -1.49608291692627 0.0793245840879273 no 3091 0.0673160245146653 4479 2861909
SGTC_2887 9044784 58.44 µM -1.49617790097106 0.0793104370724971 no 3092 0.0673036508883814 4418 6465546
SGTC_1558 st069300 45.6 µM -1.49893188343878 0.0789010862705114 no 3093 0.066945652012976 4433 24208000
SGTC_2109 5483026 200 µM -1.49959225583915 0.0788031671192472 no 3094 0.0668600274637867 4503 759335
SGTC_3082 9117008 49.47 µM -1.50482949754718 0.0780298538830929 no 3095 0.066183958971371 4523 41448529
SGTC_3289 9119912 71.43 µM -1.50863184815717 0.0774720290103093 no 3096 0.0656964453127197 4495 17014829
SGTC_3055 9094636 49.47 µM -1.51201455125473 0.076978318829108 no 3097 0.0652650804006304 4517 25236176
SGTC_1717 st033143 58.0435 µM -1.51215831164449 0.0769573899010163 no 3098 0.0652467967594872 4525 674616
SGTC_774 k060-0086 136 µM -1.51307937697809 0.0768234019623006 no 3099 0.0651297487018318 4499 5911235
SGTC_1979 st071809 45.3 µM -1.51554367057165 0.0764657917523984 no 3100 0.0648173898886492 4546 4976333
SGTC_1194 1488-0194 225 µM -1.52009199882544 0.0758090810233748 no 3101 0.0642439276282647 4491 1391452
SGTC_1208 2323-2347 50.3 µM -1.52259788035311 0.0754491090919025 no 3102 0.0639296702088878 4517 5412760
SGTC_805 3852-0218 479 µM -1.52547645560261 0.0750372087548545 no 3103 0.0635701508502615 4482 6615355
SGTC_3183 9108214 49.47 µM -1.52727205792798 0.0747811427962094 no 3104 0.0633466873118755 4508 4974831
SGTC_64 000l-0018 272.079 µM -1.52793402874142 0.07468690933186 no 3105 0.0632644591842594 4418 6811119
SGTC_545 4218-0007 221 µM -1.52997227580005 0.0743973279884522 no 3106 0.0630117957610754 4511 2840508
SGTC_1748 st037455 53.6035 µM -1.53202522512878 0.0741065251818466 no 3107 0.0627581050502883 4515 580690
SGTC_1363 1636-0063 10.4 µM -1.53656286663289 0.0734668442008111 no 3108 0.0622001958741103 4523 6072185
SGTC_1648 st011736 69.8 µM -1.54969670784165 0.0716391336793893 no 3109 0.0606071643470371 4502 2855514
SGTC_2698 st077697 67.5 µM -1.55020643753052 0.0715689091499911 no 3110 0.0605459876036951 4496 3154499
SGTC_2519 cryptotanshinone 88.04 µM -1.55213471587602 0.071303731528194 no 3111 0.0603149964439123 4517 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_427 1354-0053 47.3 µM -1.55389002154772 0.0710629975605761 no 3112 0.060105326157536 4547 6813657
SGTC_479 n-linoleoylglycine 10 µM -1.55577747722757 0.0708048366370608 no 3113 0.0598805078209663 4555 6433346 An anti-infammatory.
SGTC_270 tamoxifen 5.46 µM -1.55673353348689 0.0706743451637704 no 3114 0.0597668817836266 4524 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1811 st050069 61.5 µM -1.55831108303548 0.0704594306738204 no 3115 0.0595797614794642 4525 3877702
SGTC_2234 tolnaftate 200 µM -1.55886088756964 0.0703846472701067 no 3116 0.0595146546682541 4635 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2917 7979103 53.79 µM -1.55938827239088 0.0703129707149139 no 3117 0.0594522551691233 4519 2980565
SGTC_2299 7976368 114.88 µM -1.56131777073007 0.0700512120199091 no 3118 0.0592243963475292 4519 2979718
SGTC_2344 7990960 76.95 µM -1.56464040423172 0.0696022163559869 no 3119 0.0588336247313699 4512 140813
SGTC_1112 tnp00069 1.16933 µM -1.56544404602923 0.0694939517479783 no 3120 0.0587394137672267 4493 145826
SGTC_2253 7938677 135.83 µM -1.56649351435071 0.0693527653185533 no 3121 0.0586165628730448 4571 2301972
SGTC_2438 5259590 200 µM -1.573522093593 0.0684128891438983 no 3122 0.0577989883199904 4546 1201127
SGTC_1736 st036774 51 µM -1.57404536593094 0.0683433110635822 no 3123 0.0577384809049132 4558 1272247
SGTC_1619 st003326 88.7 µM -1.57404731954083 0.0683430513998095 no 3124 0.0577382550970023 4504 2849032
SGTC_2971 9092186 9.93 µM -1.5741907794498 0.0683239855273843 no 3125 0.0577216751874704 4508 25236400
SGTC_1654 st012436 41.8 µM -1.57640570350957 0.0680301419460405 no 3126 0.0574661673990571 4531 4323132
SGTC_1688 st021091 57.6 µM -1.58325060107716 0.067128226330112 no 3127 0.0566821786538484 4572 3656366
SGTC_2483 5729050 27.16 µM -1.58568700238278 0.0668094355576828 no 3128 0.0564051645272546 4515 2865180
SGTC_1553 gossypol 38.6 µM -1.58836710932021 0.0664601114722541 no 3129 0.0561016751958359 4473 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3068 9116768 49.47 µM -1.59512818414839 0.0655851589935321 no 3130 0.0553417870414923 4508 41904888
SGTC_422 cantharidin 155 µM -1.59676700824801 0.0653744291451161 no 3131 0.0551588263139486 4449 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2806 7952793 58.44 µM -1.59698059254526 0.0653470039214694 no 3132 0.0551350166846271 4559 2972490
SGTC_1320 1313-0481 95.3 µM -1.59787651796162 0.0652320601306884 no 3133 0.0550352305050073 4495 6813365 YLR208W SEC13
SGTC_2514 salinomycin 42.74 µM -1.60269688837558 0.0646163156667158 no 3134 0.0545007954241889 4575 23682228 A polyether potassium ionophore.
SGTC_79 0052-0007 94.094 µM -1.60761243455325 0.0639930723622612 no 3135 0.0539600435874684 4527 2801472
SGTC_3181 9108277 49.47 µM -1.60821327226381 0.0639172136873192 no 3136 0.0538942386755817 4527 17097298
SGTC_642 0335-0876 158 µM -1.60842157076453 0.0638909313221141 no 3137 0.0538714402573888 4588 6812350
SGTC_933 2914-0560 114 µM -1.60871721290893 0.0638536426773342 no 3138 0.0538390951270311 4558 463887
SGTC_1198 1612-1005 86.7 µM -1.61124336857429 0.0635357144945252 no 3139 0.0535633443301296 4601 6998509
SGTC_770 0389-1121 67.2 µM -1.61271420275595 0.0633511715550861 no 3140 0.0534033067285478 4582 6753108
SGTC_2639 lactacystin 53 µM -1.61631283600901 0.0629014168600138 no 3141 0.0530133464897894 4563 3870 A proteasome inhibitor.
SGTC_397 arbidol 50 µM -1.62173038018244 0.0622290321428864 no 3142 0.0524305454532428 4570 131410 A RNA synthesis inhibitor.
SGTC_194 1486-1323 56.904 µM -1.62427916207889 0.0619146420336473 no 3143 0.0521581212282741 4642 5178754
SGTC_1022 4477-0945 21.3 µM -1.62755097834925 0.061512884838562 no 3144 0.0518100654197725 4514 4648966
SGTC_3046 9092212 49.47 µM -1.62829434372553 0.0614218890015116 no 3145 0.0517312441334334 4625 25236637
SGTC_1806 st050005 60.3 µM -1.63321201014273 0.0608225604206004 no 3146 0.0512122074465456 4601 5194765
SGTC_1729 st035615 45.989 µM -1.63567831094979 0.0605237127834938 no 3147 0.0509534655420678 4553 17385451
SGTC_1732 st034308 51.822 µM -1.64054371140274 0.0599375302117171 no 3148 0.0504460838376478 4450 830119
SGTC_857 0438-0306 1.35 µM -1.64462660145584 0.0594490636530307 no 3149 0.050023418791966 4603 4686136
SGTC_1264 0783-0040 158 µM -1.64572888963186 0.0593177250945931 no 3150 0.0499097941837736 4477 2855798
SGTC_182 3448-4371 550.524 µM -1.64683253252601 0.0591864531539827 no 3151 0.0497962362458662 4506 3491403
SGTC_3033 9090887 49.47 µM -1.65593091315289 0.0581129171421944 no 3152 0.0488679052460443 4589 19325384
SGTC_3224 9130643 49.47 µM -1.65597607792606 0.0581076264831028 no 3153 0.04886333170429 4568 17644395
SGTC_940 3232-1287 54.8 µM -1.65662000087377 0.0580322376854995 no 3154 0.0487981630251791 4550 1585493 YIL048W NEO1
SGTC_561 1550-0330 72.9 µM -1.6566328676655 0.058030732059193 no 3155 0.0487968615405913 4533 6812934
SGTC_811 0416-0114 265 µM -1.65706029624404 0.0579807333300151 no 3156 0.0487536426194526 4579 6612453
SGTC_2597 laccaic acid a 100 µM -1.65845676805606 0.0578176161339543 no 3157 0.0486126533007208 4538 5491415 A textile dye.
SGTC_909 3448-9333 149 µM -1.6642793763125 0.0571413817915876 no 3158 0.0480283059340643 4497 3344074
SGTC_2372 9071633 200 µM -1.68042823347685 0.0552984142391026 no 3159 0.0464370133225703 4621 21321366
SGTC_2102 5377816 72.7585 µM -1.68171819434186 0.0551532475158736 no 3160 0.0463117491136716 4613 1379702
SGTC_1625 st003711 30.1 µM -1.68804545586327 0.0544455592571824 no 3161 0.0457012517627658 4592 24207034 YER133W GLC7
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.6919042546813 0.0540175005996485 no 3162 0.0453321153198896 4582 7104
SGTC_2415 st077333 57.7 µM -1.69276378490751 0.053922516190706 no 3163 0.0452502193077131 4577 2766255
SGTC_1686 st019653 115.5 µM -1.6937917709702 0.0538090898746874 no 3164 0.0451524291807538 4576 97252
SGTC_83 0170-0301 39.027 µM -1.69559757672914 0.0536102977370686 no 3165 0.0449810585097205 4608 3089716
SGTC_2720 fluspirilene 36.88 µM -1.69705855179003 0.0534498924126867 no 3166 0.044842795667871 4573 3396 An atypical antipsychotic.
SGTC_1503 4585-0012 61.3 µM -1.69974539709096 0.0531558877631475 no 3167 0.0445894131097575 4608 2922052
SGTC_1134 3477-0009 42.5 µM -1.69979715352018 0.0531502369936648 no 3168 0.0445845435724038 4595 3973534
SGTC_2449 5812982 45.77 µM -1.7016263034404 0.0529508359871581 no 3169 0.0444127217278802 4520 776185
SGTC_3037 9091026 49.47 µM -1.71050128690701 0.0519917578188458 no 3170 0.0435866078322956 4479 25236398 YIL048W NEO1
SGTC_1498 4478-3555 97.6 µM -1.71086622179092 0.0519526183966026 no 3171 0.0435529057049549 4610 3437919
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.71181356294126 0.0518511249176126 no 3172 0.0434655158939597 4610 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2792 7535235 81.82 µM -1.71206198411835 0.0518245363870721 no 3173 0.0434426231133892 4557 1281891
SGTC_3172 9105863 49.47 µM -1.71528469059168 0.0514805911489692 no 3174 0.0431465220114925 4702 2348785
SGTC_1376 2910-0861 41.3 µM -1.71616744461398 0.0513866961167166 no 3175 0.0430656999350322 4536 1112859
SGTC_429 1112-0049 25.5 µM -1.71809210592118 0.0511824498139642 no 3176 0.0428899082437293 4561 2836170
SGTC_2942 9052777 62.25 µM -1.7211579479052 0.05085843524605 no 3177 0.0426110831623807 4598 6469503
SGTC_5 0352-0601 109.883 µM -1.72164908422316 0.0508066814283358 no 3178 0.0425665529371821 4514 762456
SGTC_2974 9094440 9.66 µM -1.72305514138084 0.0506587490614468 no 3179 0.0424392769376886 4569 25236134
SGTC_826 1683-5028 118 µM -1.7236787949594 0.0505932439053557 no 3180 0.0423829225728514 4634 722377
SGTC_2080 5212524 12.4 µM -1.72721125030658 0.0502234865748758 no 3181 0.0420648655430769 4564 260183
SGTC_619 1652-1634 108 µM -1.72959378373766 0.049975315178463 no 3182 0.0418514387309007 4585 5400454
SGTC_1220 1838-0075 193 µM -1.7302279857017 0.0499094199820617 no 3183 0.041794775068834 4530 5529645
SGTC_2314 7727897 200 µM -1.73650079828429 0.049261384789613 no 3184 0.0412376616707896 4568 900724
SGTC_3306 9127676 59.7925 µM -1.73814053551055 0.0490930983526099 no 3185 0.0410930269462149 4554 41905287
SGTC_536 3852-0578 10.6 µM -1.7441529620428 0.0484799677317505 no 3186 0.0405662104825495 4613 2869208
SGTC_685 1278-0033 54.9 µM -1.74902299334635 0.0479878372499218 no 3187 0.0401435224669375 4643 3590572
SGTC_753 1322-0200 289 µM -1.75028938445052 0.047860522092234 no 3188 0.0400341958706056 4654 5403907
SGTC_762 1165-0429 115 µM -1.76099611068501 0.0467949107250686 no 3189 0.0391195306428701 4619 5967793
SGTC_1427 4048-4900 550 nM -1.7614130705768 0.0467538000199322 no 3190 0.0390842571873998 4596 24132586
SGTC_1102 cgs 12066b 26.1 µM -1.76363193004641 0.046535515790949 no 3191 0.0388969841383356 4626 6438352 A 5-HT1B full agonist.
SGTC_587 k089-0003 57 µM -1.76384138830665 0.0465149522834437 no 3192 0.0388793435490963 4550 9659696
SGTC_1562 morin hydrate 59.1 µM -1.76497679687162 0.0464036107417322 no 3193 0.0387838327145715 4609 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1390 3413-2614 145 µM -1.78113044851203 0.0448425943981114 no 3194 0.0374455712844586 4619 3421432
SGTC_1988 st071872 53.4 µM -1.78604385088217 0.0443762618853579 no 3195 0.0370460791692183 4660 16414116
SGTC_1965 Pectolinarigenin 58.4 µM -1.78911637517253 0.0440866390456327 no 3196 0.0367980377494869 4619 5320438 An anti-inflammatory.
SGTC_2132 5317594 122.667 µM -1.79099426536558 0.0439103767087043 no 3197 0.0366471076286512 4569 794577
SGTC_1640 st009078 66.4 µM -1.79183737670178 0.0438314257729944 no 3198 0.0365795098426536 4608 690618
SGTC_37 0566-0070 1.56 µM -1.79476713757358 0.0435579659831041 no 3199 0.0363454043466114 4554 1626686
SGTC_1068 loratadine 26.9 µM -1.79927013488025 0.0431403487473904 no 3200 0.0359879799424229 4654 3957 A H1 histamine antagonist.
SGTC_1326 1431-2094 10.8 µM -1.80006859292798 0.0430666367816141 no 3201 0.0359249040247073 4635 616278
SGTC_2227 7312221 64.1025 µM -1.80052468654804 0.0430245768592439 no 3202 0.0358889145838372 4713 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_570 0987-0065 62.6 µM -1.80475390229226 0.0426361467614893 no 3203 0.0355566004253615 4538 3104428
SGTC_1628 st004252 77.7 µM -1.8057209492945 0.0425477283027332 no 3204 0.0354809693254118 4622 692968
SGTC_1485 3909-9022 254 µM -1.80660774967854 0.0424667772895007 no 3205 0.0354117301637127 4678 714516
SGTC_615 k087-0205 167 µM -1.80854567880289 0.0422903081744044 no 3206 0.0352608070912821 4641 9642773
SGTC_1857 st056007 79.3 µM -1.81273972324128 0.0419104269176607 no 3207 0.0349359873298059 4622 619834
SGTC_2425 5628681 7.85 µM -1.81397692265781 0.041798895114549 no 3208 0.0348406393658697 4652 5714958
SGTC_456 gingerol 170 µM -1.82119978802742 0.0411525528616583 no 3209 0.0342882463499604 4627 442793 A herb.
SGTC_2279 7948423 32.93 µM -1.82231022383601 0.0410539074048129 no 3210 0.0342039638903161 4565 1247112
SGTC_3014 9081533 49.47 µM -1.82270576116651 0.0410188162367431 no 3211 0.0341739836364213 4637 21367265
SGTC_248 streptozotocin 5.23457 mM -1.8247306266999 0.0408395556396051 no 3212 0.0340208445740796 4666 5300 DNA alkylating agent.
SGTC_2657 nystatin 74.44 µM -1.82845580368083 0.0405114275919046 no 3213 0.0337405864438416 4650 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2374 9071832 200 µM -1.83352402079576 0.0400684395550723 no 3214 0.0333623398543132 4591 17381698
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.83526302171448 0.039917351988742 no 3215 0.0332333636387286 4618 229346 A bile salt which induces apoptosis.
SGTC_650 1328-0195 38 µM -1.8374592828432 0.0397271988471914 no 3216 0.0330710610362465 4639 2780821
SGTC_2895 9054447 58.44 µM -1.83801033126365 0.0396796046159033 no 3217 0.0330304414825405 4696 2697450
SGTC_3255 9139072 49.47 µM -1.84062437104985 0.0394544604171663 no 3218 0.0328383118909276 4653 17646060
SGTC_2408 sulbentine 18.36 µM -1.84352627274314 0.0392057413437398 no 3219 0.0326261046989352 4507 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2533 agelasine 13.65 µM -1.84940496994461 0.0387057951392144 no 3220 0.0321996791696057 4654 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_607 4491-0986 66.8 µM -1.85296391178072 0.0384056618276865 no 3221 0.0319437657012367 4635 698981 YDR232W HEM1
SGTC_12 0849-0099 9.267 µM -1.85359857207164 0.0383523393888909 no 3222 0.0318983060244916 4634 6071388
SGTC_966 1300-0360 30.2 µM -1.85695603581203 0.0380712577274988 no 3223 0.0316587046014905 4634 70588
SGTC_222 nsc-310342 10.666 µM -1.86188787742359 0.0376614208183429 no 3224 0.0313094480697103 4665 432556
SGTC_2079 5212404 121 µM -1.86387180420184 0.0374975752369953 no 3225 0.0311698545732457 4606 758462
SGTC_1509 1326-1131 80 µM -1.8647812006197 0.0374226661709634 no 3226 0.0311060397182181 4635 768313
SGTC_2448 5185112 27.17 µM -1.86603194686029 0.037319839033636 no 3227 0.0310184480019435 4639 5718189
SGTC_1127 asiatic acid 681.4 nM -1.86638016187265 0.0372912524725459 no 3228 0.0309940983123624 4605 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_295 k015-0027 31 µM -1.86940186592649 0.0370439374240283 no 3229 0.0307834625912354 4692 3887424
SGTC_2487 5918373 44.05 µM -1.87177911950998 0.036850311842486 no 3230 0.0306185840971128 4673 2876279
SGTC_1409 3909-8004 61.9 µM -1.87606689914918 0.0365031680426443 no 3231 0.0303230471151003 4679 2119279
SGTC_3104 9120930 49.47 µM -1.87656045386675 0.0364633815560944 no 3232 0.03028918087282 4662 17014836
SGTC_2838 9002687 71.43 µM -1.88177416973743 0.036045256477762 no 3233 0.0299333421720872 4638 6457060
SGTC_1682 st012968 530 nM -1.88826421836897 0.0355302680292729 no 3234 0.0294952441982629 4610 24207270
SGTC_2458 5808907 16.39 µM -1.88895156787355 0.0354760815564 no 3235 0.0294491593357782 4726 2731747
SGTC_2113 5491891 107.031 µM -1.89442275135045 0.0350471785825253 no 3236 0.0290844594598451 4649 789979
SGTC_348 k064-0012 10.7 µM -1.89459048670311 0.0350340968174941 no 3237 0.0290733380589501 4637 5066323
SGTC_2371 9071574 200 µM -1.89721844828292 0.0348296634608105 no 3238 0.0288995565006633 4671 45596039
SGTC_3023 9089636 49.47 µM -1.90033224448422 0.0345887050306174 no 3239 0.0286947662033571 4715 17249241
SGTC_2517 totarol 10 µM -1.90234220373636 0.0344338945144022 no 3240 0.0285632158076682 4663 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2390 9097792 176.6 µM -1.90409244323684 0.0342995522083269 no 3241 0.0284490728558384 4679 4497149
SGTC_2342 7990637 118.86 µM -1.91212634398993 0.0336884136787122 no 3242 0.0279299953019795 4642 2033102 YER133W GLC7
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.91955344356891 0.0331314329110426 no 3243 0.0274571647654777 4640 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_200 k038-0079 37.545 µM -1.93765220559052 0.031805866486907 no 3244 0.0263328343243893 4679 3436683
SGTC_3328 9140624 29.0385 µM -1.94152688600608 0.0315278520455294 no 3245 0.0260972007714573 4663 4904392
SGTC_2778 tioconazole 65.09 nM -1.94266885980908 0.0314462979214024 no 3246 0.0260280905257231 4568 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1188 1403-0014 4.57 µM -1.96294854622026 0.0300268383348045 no 3247 0.0248260765330535 4700 9614867
SGTC_601 0986-0029 62.9 µM -1.96406582354038 0.0299502051945409 no 3248 0.024761229482849 4641 24747981
SGTC_1777 st045864 34.765 µM -1.97457694871347 0.0292371662737058 no 3249 0.024158088560704 4693 4691462
SGTC_564 3555-0129 330 µM -1.97645418044915 0.0291113171444642 no 3250 0.0240516801619246 4641 563260
SGTC_1872 amphotericin b 148 nM -1.98037512862914 0.0288499092376633 no 3251 0.0238306962621752 4698 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1443 4112-3303 14 µM -1.9948484253723 0.0279018196410205 no 3252 0.0230297069864787 4718 704433
SGTC_2004 4023728 41.89 µM -1.99518312042685 0.0278802058314727 no 3253 0.0230114556675773 4627 360084 YDR527W RBA50
SGTC_2321 7390090 138.78 µM -2.01816339914338 0.0264292010913765 no 3254 0.0217871233125999 4679 649046
SGTC_970 1315-0089 19.5 µM -2.01932256802124 0.0263577136582035 no 3255 0.0217268518602386 4671 6811083 YLR033W RSC58
SGTC_1274 0865-0114 173 µM -2.0196269091166 0.0263389713620195 no 3256 0.0217110508881075 4684 870624
SGTC_2211 7117706 200 µM -2.02952900078456 0.0257352193012846 no 3257 0.0212022191070734 4682 822771
SGTC_1540 guanosine 70.6 µM -2.03068561097586 0.0256654598202197 no 3258 0.0211434484582149 4666 6802 Guanosine is a purine nucleoside
SGTC_3133 9127736 49.47 µM -2.03322450273455 0.0255128847619573 no 3259 0.021014923311441 4677 27243420
SGTC_52 0329-0193 875 nM -2.03488811822434 0.0254133220343068 no 3260 0.0209310659053099 4696 3739292
SGTC_899 1083-0020 478 µM -2.03968784545858 0.0251278941132647 no 3261 0.020690713140012 4720 767123
SGTC_1581 himbacine 57.9 µM -2.04271346904617 0.0249493521708033 no 3262 0.0205404053527468 4702 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2653 dihydrofissinolide 100 µM -2.04496874011649 0.0248169616873029 no 3263 0.0204289700293876 4755 6857746
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.04901313113194 0.024581020787106 no 3264 0.0202304154619037 4635 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1881 5652484 16 µM -2.05221802241003 0.0243953939126498 no 3265 0.0200742393703284 4672 2255129
SGTC_2516 gossypol 71.55 µM -2.05280821048837 0.0243613389330176 no 3266 0.0200455909664721 4705 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2704 st078022 71.1 µM -2.05782149093218 0.0240736694414271 no 3267 0.0198036361416237 4716 54697681
SGTC_2531 methyl deoxycholate 70.07 µM -2.06364192391056 0.023743269849656 no 3268 0.0195258397621291 4636 16667744 Haematoxylin.
SGTC_1925 st057770 10.1 µM -2.09158031193201 0.0222099419758652 no 3269 0.0182380376186907 4683 5989122
SGTC_3047 9092122 49.47 µM -2.0938390543537 0.0220897128526092 no 3270 0.0181371599317028 4678 17173831
SGTC_518 1021-0119 62.6 µM -2.1026490095428 0.0216260103153601 no 3271 0.0177482312090905 4681 1097762
SGTC_1034 k072-0165 12.7 µM -2.12169211623893 0.0206517455333406 no 3272 0.016931800550737 4703 5835461
SGTC_1111 tnp00062 510.699 nM -2.12526294917477 0.0204732594710419 no 3273 0.016782339014337 4689 676306
SGTC_109 0132-0036 33.701 µM -2.12985511647785 0.0202456454847789 no 3274 0.0165917883302711 4676 67274 A color developer.
SGTC_511 blebbistatin 171 µM -2.13285461341304 0.0200981345963271 no 3275 0.0164683272607277 4722 3476986 A myosin inhibitor.
SGTC_501 nsc-95397 161 µM -2.17424137811228 0.0181540920841449 no 3276 0.0148435061814544 4712 262093
SGTC_433 pimozide 108 µM -2.17873031178129 0.0179532062453726 no 3277 0.0146758542908105 4662 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2596 sinensetin 100 µM -2.19733655117484 0.0171406416386427 no 3278 0.0139982095262755 4688 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1892 st058411 7.36 µM -2.20021333244274 0.0170178563763023 no 3279 0.0138958814076532 4712 3934738
SGTC_2825 7998094 58.44 µM -2.20033390309896 0.0170127267018414 no 3280 0.0138916067867862 4684 2987815
SGTC_827 3253-0474 693 µM -2.21057916927248 0.0165816434992352 no 3281 0.0135324962866666 4732 5402065
SGTC_1846 st056244 14.8 µM -2.21079672551582 0.0165725918356102 no 3282 0.0135249583515957 4717 5393182
SGTC_3209 9113616 49.47 µM -2.2172937941856 0.016304216485009 no 3283 0.013301510847901 4714 16649353
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.21739283134933 0.0163001545156819 no 3284 0.0132981295793302 4706 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_917 harmaline 728.087 nM -2.22459888325269 0.0160069178968206 no 3285 0.0130540888411906 4668 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2116 5511452 16.8835 µM -2.22582419017398 0.015957508840022 no 3286 0.0130129799198572 4736 870744
SGTC_3021 9087658 49.47 µM -2.23248409541489 0.0156912365945441 no 3287 0.0127914926221215 4747 25237042
SGTC_289 k017-0060 526 µM -2.24008519675388 0.0153920004464029 no 3288 0.0125426961905559 4735 5512909
SGTC_1799 st045822 46.1415 µM -2.24686806859068 0.0151291259589997 no 3289 0.0123242299791723 4720 3674992
SGTC_2251 lansoprazole 556 µM -2.27010352189559 0.014257658195856 no 3290 0.0116006513513593 4724 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2822 7994718 71.43 µM -2.27198139753576 0.0141891541225576 no 3291 0.0115438169619957 4735 1018011
SGTC_1993 st073995 70.8 µM -2.29622963189677 0.013329746606662 no 3292 0.0108313775592406 4733 3098394
SGTC_2818 7996756 12.99 µM -2.31023362329239 0.0128541921868793 no 3293 0.0104376117478784 4732 2241621
SGTC_2468 5987765 72.9 µM -2.31516893489539 0.0126901295358137 no 3294 0.0103018443151764 4752 26772094
SGTC_1713 st033146 12.748 µM -2.3161775041413 0.0126568259592879 no 3295 0.0102742894686056 4717 674619
SGTC_1690 st023502 41.2 µM -2.32705166279564 0.0123025320267891 no 3296 0.0099812578706062 4755 24207482
SGTC_1932 st074806 40.9 µM -2.34848216690068 0.0116293858305401 no 3297 0.00942505091558491 4748 17251235
SGTC_3189 9110682 49.47 µM -2.37723111630941 0.0107767258057387 no 3298 0.00872157753727741 4737 17122418
SGTC_1396 3511-0007 98.6 µM -2.39144723581493 0.0103755811882601 no 3299 0.00839104799535517 4750 X1396
SGTC_2316 5844804 197.44 µM -2.39407330575531 0.010302921511739 no 3300 0.00833120911300611 4740 776813
SGTC_2459 5811157 9.22 µM -2.39991631204043 0.0101428437504569 no 3301 0.00819941026536527 4737 2870684 YBR192W RIM2
SGTC_3034 9090421 49.47 µM -2.40042761685509 0.0101289396051714 no 3302 0.00818796455856503 4735 17173761
SGTC_897 1000-0139 31.4 µM -2.41181144715818 0.00982365174899887 no 3303 0.00793674407867128 4739 6151020
SGTC_132 0417-1715 25.805 µM -2.41934617923621 0.00962603550929124 no 3304 0.00777421759644128 4727 6769098
SGTC_2188 6126565 140.678 µM -2.42464457521852 0.00948916137398223 no 3305 0.00766169030712993 4721 874518
SGTC_2892 9047358 58.44 µM -2.43547337800338 0.00921470345978914 no 3306 0.00743615946859233 4756 6466771
SGTC_1438 4092-1045 4 µM -2.44225549652068 0.00904637007121687 no 3307 0.00729790639447601 4782 1351342
SGTC_693 4161-2696 114 µM -2.44625852259712 0.00894828330408413 no 3308 0.00721737279381297 4766 805759
SGTC_947 3447-0010 211 µM -2.44955607356618 0.00886818406633584 no 3309 0.00715162185167736 4717 748350
SGTC_2141 5621638 7.665 µM -2.46462150446913 0.0085101771977632 no 3310 0.00685790256655574 4757 2856238
SGTC_226 1,3-diallylurea 8.28947 mM -2.47578584481974 0.00825311707662977 no 3311 0.0066471647160401 4764 74537 YKL182W FAS1
SGTC_2916 7875993 68.79 µM -2.49679222959581 0.00778787932220021 no 3312 0.00626611804939013 4715 1299250
SGTC_112 phenothiazine 287.218 µM -2.50567751831627 0.00759814215022599 no 3313 0.00611085154169649 4743 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3178 9107506 49.47 µM -2.51745439182385 0.00735293694026597 no 3314 0.00591031361636375 4755 8897194
SGTC_1587 estradiol valerate 56.1 µM -2.51856986355385 0.00733007744248195 no 3315 0.0058916252375527 4787 13791 A steroid.
SGTC_1884 5633444 25 µM -2.52924650020121 0.00711442975864784 no 3316 0.00571538573861642 4723 5724239
SGTC_1560 lithocholic acid 53.1 µM -2.53419843954822 0.00701632424963168 no 3317 0.00563524436639473 4745 9903 A bile acid which acts as a detergent.
SGTC_2787 5284540 71.43 µM -2.53888891569528 0.00692450186054133 no 3318 0.00556025630540456 4757 736958
SGTC_34 0469-0683 81.75 µM -2.56453001594043 0.00644105652919573 no 3319 0.00516578213813408 4767 3690923
SGTC_3052 9092717 49.47 µM -2.59362936853477 0.00592879248044087 no 3320 0.00474844013873893 4760 25237534
SGTC_2288 7946289 167.31 µM -2.60221133866368 0.0057847788626411 no 3321 0.0046312376850782 4753 1246052
SGTC_978 1416-0512 87.4 µM -2.62455214114787 0.00542433488497816 no 3322 0.00433815035124229 4774 6814003
SGTC_1213 1315-0166 115 µM -2.6376716656285 0.00522209705766274 no 3323 0.00417386812567294 4757 768401
SGTC_1865 st057639 52.2 µM -2.64101034699117 0.00517171412223859 no 3324 0.00413295974410432 4777 688818
SGTC_2623 humulene 100 µM -2.70609464796391 0.00427225429822793 no 3325 0.00340398196951064 4752 6187145 An anti-inflammatory.
SGTC_3040 9091894 49.47 µM -2.76206105416188 0.00361354732216932 no 3326 0.00287188682858845 4757 25236966
SGTC_1795 st049545 62.3 µM -2.76778111966218 0.00355164475575009 no 3327 0.00282196732636271 4780 5291882
SGTC_2357 9067248 200 µM -2.79802683362738 0.00323988082274132 no 3328 0.00257079204777204 4747 9150235
SGTC_1854 st056233 32.9 µM -2.80639535290064 0.00315808325713556 no 3329 0.00250495911604167 4779 5393174
SGTC_2356 9061756 188.97 µM -2.81282671620742 0.00309648857981994 no 3330 0.0024554053589183 4779 20104043
SGTC_772 k072-0172 35.3 µM -2.82279782617026 0.00300312961696725 no 3331 0.00238032909825496 4790 5861980
SGTC_1041 0206-0046 107 µM -2.84745371259101 0.00278307223080913 no 3332 0.00220352512725305 4777 50494
SGTC_1808 st050063 61.5 µM -2.85157052617497 0.00274778063634466 no 3333 0.00217519172000864 4778 4011993
SGTC_1720 st037298 9.481 µM -2.88012124513086 0.00251393845390166 no 3334 0.0019876113285177 4766 597396
SGTC_290 2043-6722 48.1 µM -2.90435570968605 0.00232973323161859 no 3335 0.00184004894354745 4798 773758 YLR208W SEC13
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.9151907512652 0.00225140174912164 no 3336 0.00177735601770665 4788 16623 A steroid.
SGTC_1847 st056231 15 µM -2.9165189342501 0.00224196571059564 no 3337 0.00176980619261295 4778 5393180
SGTC_2334 9017922 200 µM -2.92438344401931 0.0021868230723108 no 3338 0.00172569653382615 4774 3163164
SGTC_2332 7982454 138.89 µM -2.9388495803925 0.00208859285948431 no 3339 0.00164716456627197 4757 2981748
SGTC_1123 mangostin 811.285 nM -2.96047186770197 0.00194921950393838 no 3340 0.00153584086851915 4783 5281650 An antioxidant.
SGTC_1927 st060202 13.8 µM -2.97275564795118 0.00187385663585183 no 3341 0.00147569655445122 4772 688887
SGTC_1849 st056239 19.2 µM -3.01382033771729 0.00164074609567817 no 3342 0.00128990264828594 4782 5393181
SGTC_50 0929-0078 56.389 µM -3.06123083286667 0.00140466121906688 no 3343 0.00110214542062063 4752 1377751
SGTC_2626 ethyl orsellinate 100 µM -3.23806005929902 0.000772290428894511 yes 3344 0.000601727359305276 4777 75653 A natural product.
SGTC_2769 toremifene 3.73 µM -3.27350480903342 0.000682584693365484 yes 3345 0.000531112915522778 4795 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_930 2810-3379 265 µM -3.29039004011724 0.000643322198696963 yes 3346 0.000500242981231545 4788 1015764
SGTC_1209 2323-2347 50.3 µM -3.41707843560153 0.000408913008680912 yes 3347 0.000316485201598052 4802 5412760
SGTC_2222 6885208 172.143 µM -3.42717069677131 0.000394155546103295 yes 3348 0.000304952774241458 4810 609514
SGTC_2580 diallyl disulphide 81.36 µM -3.46572556080531 0.000342211708587106 yes 3349 0.000264401375937659 4794 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1189 1431-2119 7.28 µM -3.72466926525896 0.000127665236607302 yes 3350 9.77857271005906e-05 4805 3107275
SGTC_2308 7584454 197.62 µM -3.78958330707457 9.87041645278771e-05 yes 3351 7.54500998446886e-05 4793 893577
SGTC_2309 7664088 163.95 µM -3.82788068761495 8.46421420343203e-05 yes 3352 6.4625690158376e-05 4793 704922
SGTC_2162 5663267 200 µM -3.83660349113915 8.17142306288795e-05 yes 3353 6.23738198709464e-05 4807 6456493
SGTC_2338 7999974 200 µM -3.85068649529194 7.71873844462796e-05 yes 3354 5.88935987286719e-05 4796 315925
SGTC_3325 9138760 55.175 µM -3.9010777050841 6.28493672696942e-05 yes 3355 4.78827013374244e-05 4802 43844959
SGTC_48 0382-0018 55 µM -4.62713431456411 2.47535646638647e-06 yes 3356 1.8538004038374e-06 4808 762596