SGTCid condition conc unit SKM1|YOL113W.score SKM1|YOL113W.strain.pval SKM1|YOL113W.strain.significant SKM1|YOL113W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_530 4358-1714 28 µM 10.5976837275941 1.05750042770657e-24 yes 1 1.52725862070526e-26 1 1564641
SGTC_2849 9019321 12.99 µM 7.19078180343273 2.44114049016309e-12 yes 2 3.22106822659477e-13 6 16489627
SGTC_533 1222-0222 6.71 µM 7.0508797963032 6.26041498471425e-12 yes 3 8.88950174901776e-13 2 3982874
SGTC_2415 st077333 57.7 µM 6.39572599259015 4.06409976420012e-10 yes 4 7.98931596858021e-11 10 2766255
SGTC_2765 myclobutanil 7.74 µM 6.25499949343239 9.46558389087544e-10 yes 5 1.9875860067369e-10 11 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2003 4023581 200 µM 5.3073172108608 1.76208624638692e-07 yes 6 5.56252380840066e-08 18 16641307
SGTC_1871 st057448 67.3 µM 5.28181992152152 2.0055531635007e-07 yes 7 6.39534447205673e-08 5 691747
SGTC_1765 st044815 90.4 µM 5.27644932877041 2.06082390912809e-07 yes 8 6.58554550695933e-08 7 645695
SGTC_519 k048-0011 62.8 µM 4.71386504424179 3.07980034926702e-06 yes 9 1.21530838755112e-06 8 6836379
SGTC_2479 5617353 43.85 µM 4.66056149349959 3.92117882838004e-06 yes 10 1.5767396291434e-06 18 2731746
SGTC_1035 k081-0041 55.2 µM 4.55916034126063 6.16479435269616e-06 yes 11 2.56792744747623e-06 14 731709
SGTC_3110 9122132 49.47 µM 4.49462125635083 8.18299777678628e-06 yes 12 3.48469404753244e-06 14 918317
SGTC_203 k066-0004 30.888 µM 4.27797656162715 2.06063957409845e-05 yes 13 9.4299936872064e-06 15 6795412
SGTC_2774 tamoxifen 10.92 µM 4.18186527044182 3.06295553813751e-05 yes 14 1.44563645401159e-05 12 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2154 5570129 200 µM 4.15477689448277 3.41990737552783e-05 yes 15 1.62802547665591e-05 11 673366
SGTC_331 k048-0133 24.5 µM 3.98693534163268 6.67351511534232e-05 yes 16 3.34661283184074e-05 9 6813582
SGTC_1022 4477-0945 21.3 µM 3.97679483409274 6.94304117943738e-05 yes 17 3.49251901590917e-05 21 4648966
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 3.91853691713401 8.70107767051964e-05 yes 18 4.45440430834066e-05 20 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2858 9025781 8.96 µM 3.89449762763602 9.54205743699904e-05 yes 19 4.92012274345083e-05 103 4894980 YPL153C RAD53
SGTC_518 1021-0119 62.6 µM 3.84566659094173 0.000114908796638714 yes 20 6.01125742514746e-05 50 1097762
SGTC_2766 oltipraz 83.91 µM 3.64135692257554 0.000244440528031893 yes 21 0.000135602417110443 38 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_42 0133-0086 60.653 µM 3.54260630094657 0.000347473057213069 yes 22 0.000198096853465897 41 162923 Model of phenazepam hydroxylation.
SGTC_1443 4112-3303 14 µM 3.50933958894091 0.000390430799752126 yes 23 0.000224610471291916 13 704433
SGTC_94 0334-0113 514.748 µM 3.49491314242673 0.00041055060423844 yes 24 0.000237108025656281 34 6795178
SGTC_2299 7976368 114.88 µM 3.4504613608893 0.000478753550894801 yes 25 0.000279814635477837 47 2979718
SGTC_525 k781-2675 26.7 µM 3.40872292485513 0.00055220698356315 yes 26 0.000326338669690365 71 3651118 YDL195W SEC31
SGTC_3225 9130819 49.47 µM 3.39980813528606 0.000569189250313248 yes 27 0.000337165762183387 43 4547121
SGTC_1550 gossypolone 36.6 µM 3.38434735245033 0.000599790500390309 yes 28 0.000356738395867294 29 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_941 3237-0776 460 µM 3.38426306029028 0.000599961427138759 yes 29 0.000356847941888286 40 760008
SGTC_3349 9149703 23.001 µM 3.38291348586939 0.000602704214855417 yes 30 0.000358606109323899 27 4910494
SGTC_2936 9038235 15.59 µM 3.35078988165121 0.000671509117775349 yes 31 0.000402907100396122 46 4749415
SGTC_1128 3448-9350 235 µM 3.34957858644078 0.000674240068264797 yes 32 0.000404672964907722 42 619386
SGTC_2150 5556613 200 µM 3.34765919945117 0.000678588449552681 yes 33 0.000407485819754303 33 743190
SGTC_2962 9082311 13.18 µM 3.33228852535513 0.000714355161544321 yes 34 0.000430674527543664 43 16459453
SGTC_1346 1488-2224 62.4 µM 3.30325396885554 0.000786700126825977 yes 35 0.000477848953600486 33 3722427
SGTC_1488 4013-0813 75.9 µM 3.26249879141124 0.000899663357161598 yes 36 0.000552173218596249 12 2910057
SGTC_926 2268-1401 59.4 µM 3.21264293813332 0.00105806403391006 no 37 0.000657598428143782 50 2931578
SGTC_3216 9129716 49.47 µM 3.21159760519715 0.00106164347141751 no 38 0.000659995611110468 56 8056934
SGTC_1471 k673-0312 37 µM 3.19564732335919 0.00111765583931096 no 39 0.000697587676047186 28 24099884
SGTC_2270 7924575 90.91 µM 3.17915880239398 0.00117839380812951 no 40 0.000738515732234489 42 1262135
SGTC_1855 st056195 39.6 µM 3.1774736610661 0.00118476854324021 no 41 0.000742820917718475 49 4028379
SGTC_1124 fisetin 1.16336 µM 3.1659006607574 0.00122940813771881 no 42 0.00077301791238511 67 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2695 st077686 51.995 µM 3.15037987133529 0.00129169196762687 no 43 0.000815291488993545 62 2876092
SGTC_1624 st003710 6.25 µM 3.14491962893268 0.00131428070709271 no 44 0.000830662318441987 81 24207033
SGTC_2772 vinpocetine 57.06 µM 3.14408462453179 0.00131776673652312 no 45 0.000833036260544809 53 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_74 000s-0487 160.283 µM 3.14105790936997 0.00133047382286569 no 46 0.0008416937170751 47 677548
SGTC_2702 st077768 96.8 µM 3.11173869051004 0.00145948979321728 no 47 0.000929945249144033 49 6484119
SGTC_1863 st057641 20.1 µM 3.06996393979485 0.00166308649562886 no 48 0.00107042308703648 51 3921635
SGTC_2779 methotrexate 400 µM 3.05825030273242 0.00172464632526117 no 49 0.00111316765843912 62 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2153 5569715 200 µM 3.05761098514363 0.00172806513881445 no 50 0.0011155450241664 35 2054701
SGTC_2778 tioconazole 65.09 nM 3.05430131025603 0.00174586277600093 no 51 0.0011279269340458 118 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_818 4072-2707 53.5 µM 3.04790228232461 0.00178074708773716 no 52 0.00115222425097765 43 882871
SGTC_2073 5212005 126 µM 3.04736833856124 0.00178368635540598 no 53 0.00115427316845512 23 691789
SGTC_2378 9074213 121.43 µM 3.01836456638797 0.00195013545331992 no 54 0.0012707148441388 69 657714
SGTC_2618 avocadyne 43.43 µM 3.01248791059196 0.00198553304013393 no 55 0.0012955787838392 64 3015189
SGTC_445 e6 berbamine 66 µM 2.9928622119367 0.0021080152280378 no 56 0.0013818724747054 190 6610268 A calcium/calmodulin antagonist.
SGTC_2212 7123476 200 µM 2.9891357767252 0.00213203147164132 no 57 0.00139883889172151 16 1085715
SGTC_2512 diallyl trisulfide 49.23 µM 2.97741406666949 0.00220920251774352 no 58 0.00145345560965354 37 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3326 9140064 16.379 µM 2.96349905035241 0.0023040945550994 no 59 0.00152081500196758 57 1868434
SGTC_581 0958-0271 211 µM 2.94574884790391 0.00243049251865998 no 60 0.00161086938998797 125 4591145
SGTC_2254 7938975 95.19 µM 2.92958703429405 0.00255100081502742 no 61 0.00169706373671457 105 2969277
SGTC_2722 naftopidil 47.16 µM 2.92188181216163 0.00261033330800398 no 62 0.00173961769117616 46 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.90356021809633 0.00275645266407984 no 63 0.00184473005705301 78 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_204 PMA1.184 62.41 µM 2.90338750995493 0.00275786449480084 no 64 0.00184574779693047 83 2252213 YGL008C PMA1
SGTC_2198 6589944 200 µM 2.89170695859437 0.00285487723210091 no 65 0.00191577571436673 43 5290268
SGTC_1675 st018485 24.5 µM 2.89156876499875 0.00285604319347585 no 66 0.00191661847886596 89 3323024
SGTC_1978 st071761 42 µM 2.88960033130625 0.00287269787275948 no 67 0.00192865946769114 48 5147680
SGTC_1881 5652484 16 µM 2.88462572759134 0.00291517841745419 no 68 0.00195939622359416 84 2255129
SGTC_16 erodoxin 22.806 µM 2.88415541146317 0.00291922383210501 no 69 0.00196232508027981 122 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2909 7941780 10.49 µM 2.87884977506612 0.00296521198376897 no 70 0.00199564203574996 61 1243215
SGTC_2452 5863136 48.41 µM 2.86390793715327 0.00309825383796963 no 71 0.00209224805618365 76 2184096
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.83817232083694 0.00334005291585058 no 72 0.00226863399445154 45 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3212 9128307 49.47 µM 2.81154087996009 0.00360800281526469 no 73 0.00246524124603177 111 27243542
SGTC_2726 cimetidine 79.27 µM 2.81007105837372 0.00362333808141504 no 74 0.0024765281520275 36 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2517 totarol 10 µM 2.79283081267193 0.00380762930618692 no 75 0.00261245058781905 77 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1530 rhein 70.4 µM 2.79094641466804 0.0038282737655256 no 76 0.00262770860595188 75 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2202 7226349 200 µM 2.79060075143128 0.00383207153868999 no 77 0.00263051617191197 49 844334
SGTC_805 3852-0218 479 µM 2.74804666095277 0.00432622080537153 no 78 0.00299757382805373 141 6615355
SGTC_3355 9151058 44.0485 µM 2.73956757912422 0.0044312305616311 no 79 0.0030760032953781 57 17015728
SGTC_1711 st032263 62.8 µM 2.72731393717504 0.0045870101424117 no 80 0.00319261285298909 73 3958979
SGTC_2721 ifenprodil 61.44 µM 2.7179876861599 0.00470883084121072 no 81 0.00328401412350292 85 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2729 fluphenazine 10.66 µM 2.7079885814846 0.00484263854613781 no 82 0.0033846175674759 87 3372 An atypical antipsychotic.
SGTC_1839 st053978 48 µM 2.70010295196386 0.00495054337042677 no 83 0.00346590109643541 85 3788398
SGTC_2347 9049783 174.81 µM 2.69800400345718 0.00497962343518281 no 84 0.00348783008784296 117 6467988 YPL169C MEX67
SGTC_246 cycloheximide 667 µM 2.68264874924229 0.00519703299452994 no 85 0.003652083056453 67 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1757 st041620 31.8375 µM 2.6757114274597 0.0052979965629872 no 86 0.00372854108555704 99 5289815
SGTC_2911 7942208 15.64 µM 2.64060063016962 0.00583621828281185 no 87 0.0041379605592898 67 1243384
SGTC_1484 3473-2379 286 µM 2.60694687570114 0.00639707742946428 no 88 0.00456767661824376 86 671917
SGTC_1356 1502-0781 85.8 µM 2.59974361777344 0.00652314469661726 no 89 0.00466467161651771 90 567702
SGTC_93 0109-0045 59.227 µM 2.59155233406672 0.0066691696487357 no 90 0.00477720041829138 129 88733
SGTC_1911 st060208 74.3 µM 2.5886371602059 0.00672183095118653 no 91 0.0048178282291696 116 688783
SGTC_1642 st009582 77.7 µM 2.57838620718935 0.00690993937969501 no 92 0.00496314935572693 92 6739311
SGTC_3250 9135583 49.47 µM 2.57738542566733 0.00692855078423008 no 93 0.00497754391859814 67 7699353
SGTC_1515 3460-0031 42.1 µM 2.56086478162511 0.00724224292887409 no 94 0.00522059929079783 73 2876596
SGTC_95 0471-0001 561.058 µM 2.54011424769781 0.00765395122049165 no 95 0.00554081315634246 118 4015405
SGTC_1926 methyl fluorone black 53.6 µM 2.52623904343234 0.00794061410545503 no 96 0.00576455023825438 149 72721 Reacts with homocysteine.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.51774055958253 0.00812081890221246 no 97 0.00590551421512681 159 91467 include heat shock
SGTC_2441 5730946 39.09 µM 2.48550844767624 0.0088373523546373 no 98 0.00646832583791543 122 1774275
SGTC_1439 4092-1168 46 µM 2.48507069851857 0.0088474534834151 no 99 0.00647628541146296 88 2886240
SGTC_1285 0929-0069 65.5 µM 2.47383222868691 0.009110270531341 no 100 0.00668362267395903 119 1206237
SGTC_3242 9133940 49.47 µM 2.47125851339175 0.00917141136701669 no 101 0.00673192251870533 108 17248444
SGTC_1120 ficusin 1.78878 µM 2.45372711644129 0.00959752276970295 no 102 0.00706921132190603 119 6199 A DNA cross-linker.
SGTC_442 cape 100 µM 2.44964896261866 0.00969909085600464 no 103 0.0071497773834409 90 5281787
SGTC_1969 st069479 40.1 µM 2.44929261748294 0.00970801023340021 no 104 0.00715685549866623 91 3895485
SGTC_2370 9071495 200 µM 2.42818444582675 0.0102492991189747 no 105 0.00758731189172061 150 21791103
SGTC_1821 st053465 65.6 µM 2.42489663282245 0.0103359374445634 no 106 0.00765637302185179 92 675086
SGTC_2930 9013230 14.89 µM 2.40881727598513 0.0107689091509104 no 107 0.00800215428706777 172 2995857
SGTC_100 0086-0128 49.5915 µM 2.37793436477956 0.0116449437211373 no 108 0.00870496226996033 191 93297
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.35976885868062 0.0121886116300792 no 109 0.00914316238772007 95 616764
SGTC_125 0133-0007 11.75 µM 2.34427263047078 0.0126696448936526 no 110 0.00953211516903813 123 26541
SGTC_1130 3454-2858 15.9 µM 2.32536787148059 0.0132786592436011 no 111 0.0100261489596369 216 715628 YIL048W NEO1
SGTC_92 0063-0024 660.874 µM 2.3212150030706 0.0134157809029815 no 112 0.0101376214272628 131 3594437
SGTC_145 3737-0113 38.366 µM 2.31641483578722 0.0135757972165477 no 113 0.010267814744378 234 6849351
SGTC_3294 9122953 26.2835 µM 2.31449221914231 0.0136403492504259 no 114 0.0103203687853848 145 16459826
SGTC_1125 tnp00248 1.32998 µM 2.31315422185415 0.0136854287799104 no 115 0.0103570807259303 212 24207736
SGTC_1487 3970-0795 2.82 µM 2.31142297607708 0.0137439482721394 no 116 0.0104047515357858 131 3765103
SGTC_2077 5212015 200 µM 2.30376810631924 0.0140052922648084 no 117 0.0106178321851325 190 780900
SGTC_2147 5545932 89.7195 µM 2.29468939947283 0.0143207901291521 no 118 0.0108754653681983 118 797404
SGTC_350 k064-0020 19.8 µM 2.2804741490031 0.0148270819505602 no 119 0.0112897911447224 171 2790705
SGTC_1960 st011366 51.8 µM 2.27989534300698 0.0148480188577466 no 120 0.0113069481685385 107 3972846
SGTC_3249 9135183 49.47 µM 2.2737899721686 0.0150704187135179 no 121 0.0114893087327977 151 4902779
SGTC_344 k064-0035 6.43 µM 2.26451494714103 0.0154137552134371 no 122 0.0117712307454784 152 5088750
SGTC_341 1486-1430 230 µM 2.26017829072384 0.0155765770413513 no 123 0.0119050938274359 167 2054753 YPL210C SRP72
SGTC_1625 st003711 30.1 µM 2.24912723147152 0.0159981818197843 no 124 0.012252201237556 168 24207034 YER133W GLC7
SGTC_3219 9131112 49.47 µM 2.24745295278412 0.0160629022509649 no 125 0.0123055470503104 163 17612988 YMR079W SEC14
SGTC_2433 5607874 27.82 µM 2.2264379361343 0.0168945253876302 no 126 0.0129924309076741 169 2252428
SGTC_1395 3486-0190 4.35 µM 2.22257487501974 0.0170513376441046 no 127 0.0131222399844469 157 6748079
SGTC_1048 3161-0300 24.5 µM 2.21848876969925 0.0172185561417242 no 128 0.0132607622348237 171 2165101
SGTC_1910 st062352 60.4 µM 2.21742445347383 0.0172623411912049 no 129 0.0132970501117465 196 2245730
SGTC_909 3448-9333 149 µM 2.21120770282099 0.0175199977949364 no 130 0.0135107286122734 138 3344074
SGTC_1368 1852-0141 284 µM 2.20728927185963 0.0176840804409789 no 131 0.0136469281633742 182 2838987
SGTC_1697 st025554 27.742 µM 2.20052622894705 0.0179703652111993 no 132 0.013884790558416 142 1269519
SGTC_260 nsc-65238 3.989 µM 2.18710708172453 0.018550120895537 no 133 0.0143673538946067 148 3246252
SGTC_1266 0828-0227 32.9 µM 2.18306224389447 0.0187279661706601 no 134 0.0145156132713381 170 3913820
SGTC_250 brefeldin a 552.239 µM 2.18168953351898 0.0187886509974492 no 135 0.0145662269537483 119 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1127 asiatic acid 681.4 nM 2.17795834591616 0.0189544455910934 no 136 0.0147045690108653 186 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1747 st037496 66.6 µM 2.17571436034597 0.0190547546417153 no 137 0.0147883128690798 196 723305
SGTC_715 0868-0130 184 µM 2.17148584396853 0.0192450017996095 no 138 0.0149472330408651 134 2876258
SGTC_349 k015-0014 24 µM 2.16270294209527 0.0196453208456168 no 139 0.0152820173377313 176 2196908
SGTC_2906 7926292 26.41 µM 2.15905915934685 0.0198134654041291 no 140 0.0154227887910279 201 2966319
SGTC_2703 st077852 53.4 µM 2.15514410517955 0.0199954876128943 no 141 0.0155752796294091 180 6281836
SGTC_2822 7994718 71.43 µM 2.15485346584695 0.0200090566607563 no 142 0.0155866514075967 145 1018011
SGTC_408 cantharidin 100 µM 2.15319611492031 0.0200865825915986 no 143 0.0156516344444217 193 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2582 agaric acid 100 µM 2.15130085039184 0.0201755495148829 no 144 0.0157262305980176 611 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1196 1588-0294 184 µM 2.1434220643455 0.0205489831802456 no 145 0.0160396114745057 169 6144269
SGTC_593 1203-0218 61.7 µM 2.14074690803072 0.0206771030091937 no 146 0.016147226755779 175 3666956
SGTC_1460 k062-0059 9.15 µM 2.13655649617249 0.020879151750716 no 147 0.0163170406052072 188 1373085
SGTC_209 4077-0173 175.592 µM 2.13493356023524 0.0209578524686016 no 148 0.0163832187678993 98 15993494
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.13038306453416 0.0211798588417997 no 149 0.0165700004091622 220 676296 Flavone; oxidizing agent.
SGTC_1981 st071826 47 µM 2.12957014727304 0.0212197275794144 no 150 0.0166035589273952 143 11838600
SGTC_1493 4348-0038 111 µM 2.12848855100132 0.0212728718167425 no 151 0.0166482991044082 217 800424
SGTC_3041 9091929 49.47 µM 2.1270412959886 0.0213441587374828 no 152 0.0167083260729167 194 25236887
SGTC_3200 9114385 49.47 µM 2.12270323969312 0.0215590480705593 no 153 0.016889363685551 188 17018030 YLR208W SEC13
SGTC_2131 toluylene red 5.2905 µM 2.12253523789889 0.0215674068266268 no 154 0.0168964084162149 214 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1117 retinoic acid 1.10837 µM 2.11924831774737 0.0217314959401453 no 155 0.0170347434267831 182 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1809 st050081 57.6 µM 2.11456467457349 0.0219671332188188 no 156 0.0172335335545864 179 5036894
SGTC_2017 5132927 60.65 µM 2.10671056187828 0.0223671202006893 no 157 0.0175713380636635 213 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2495 cafestol 54.53 µM 2.10414490133908 0.0224991057825435 no 158 0.0176829045481287 198 16667697 An anti-infammatory.
SGTC_3087 9117406 49.47 µM 2.08782512099001 0.0233541091605364 no 159 0.0184068063183496 182 42546093
SGTC_205 1486-1330 71.903 µM 2.08757353868927 0.0233675008117926 no 160 0.0184181605147817 136 4118834
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.08597199014554 0.0234529023548942 no 161 0.0184905801755546 180 279621
SGTC_491 tetrandrine 80.3 µM 2.08494655849573 0.0235077206148419 no 162 0.0185370758992952 143 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1968 st069590 43.6 µM 2.0820346379139 0.0236639761132114 no 163 0.0186696529839143 173 6384066
SGTC_2132 5317594 122.667 µM 2.07695441042695 0.0239386754305534 no 164 0.0189028835746658 159 794577
SGTC_1504 k297-0033 30 µM 2.07208152236701 0.0242046766198999 no 165 0.019128919604352 162 4388117
SGTC_1 0258-0098 57.368 µM 2.06964364895961 0.0243386841971698 no 166 0.0192428636773985 156 6790032 YDR047W HEM12
SGTC_262 fenpropimorph 62.5 µM 2.0664121476834 0.0245172764024196 no 167 0.0193947899414231 188 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1663 st014140 55.4 µM 2.05674670568525 0.0250580236804686 no 168 0.0198552984691884 224 4207120
SGTC_1915 st067105 30.6 µM 2.04357115287349 0.0258112215068279 no 169 0.0204979657546141 240 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1326 1431-2094 10.8 µM 2.04146753304443 0.0259332142221294 no 170 0.0206021889059514 242 616278
SGTC_2801 7907800 81.82 µM 2.03715927881446 0.0261845636340125 no 171 0.0208170415412541 235 6620925
SGTC_2935 9038016 29.96 µM 2.02532630438876 0.0268854154684942 no 172 0.0214169346100625 217 6463195
SGTC_259 usnic acid 108.925 µM 2.02177441687716 0.0270988203472814 no 173 0.0215998309414485 218 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_574 1315-0397 40 µM 2.02079112511842 0.0271581477887553 no 174 0.0216506959611437 274 6794277
SGTC_202 3594-0513 34.79 µM 2.01306302244047 0.0276282100918616 no 175 0.0220539998535495 150 708429
SGTC_3141 9094609 49.47 µM 2.00513865445626 0.0281172324835772 no 176 0.0224741130406562 231 25236309 YDL196W YDL196W
SGTC_1880 MG-132 525 µM 2.00285778017201 0.0282593164295267 no 177 0.0225962779440872 183 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3340 9146634 11.102 µM 2.00099185175261 0.0283759958582554 no 178 0.022696634001769 207 4907387
SGTC_2928 9011484 9.79 µM 1.99989321613238 0.0284448825793432 no 179 0.0227558979280811 217 2994751
SGTC_1651 st011928 86.1 µM 1.98769009395969 0.029219441897666 no 180 0.0234229875877348 196 720198
SGTC_1605 st000082 49.1 µM 1.97221294726889 0.030226931637237 no 181 0.0242926511340191 212 1114022
SGTC_348 k064-0012 10.7 µM 1.97051565405345 0.0303391487727397 no 182 0.0243896513538866 188 5066323
SGTC_944 3370-0224 231 µM 1.96270484397478 0.0308600219670617 no 183 0.0248402399777906 236 4580514
SGTC_3258 9138477 49.47 µM 1.95818567694406 0.0311647536136109 no 184 0.0251041145928375 215 4970355
SGTC_2194 5927483 104.545 µM 1.95644406102267 0.031282854977529 no 185 0.0252064330141392 233 760979
SGTC_692 k241-0027 77.8 µM 1.95251196401507 0.0315508574220728 no 186 0.0254387259628458 218 3600480
SGTC_1313 1220-0047 237 µM 1.95116066685681 0.0316433956677713 no 187 0.0255189681537374 284 3528706
SGTC_2636 apigenin dimethyl ether 100 µM 1.95055429103003 0.0316849937662834 no 188 0.0255550445579334 286 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_264 promethazine 12.5 mM 1.9480776838292 0.0318553613767765 no 189 0.0257028343013717 347 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2482 5981709 142.65 µM 1.94686490576564 0.0319390648534988 no 190 0.0257754665009019 271 877755
SGTC_511 blebbistatin 171 µM 1.94061746041872 0.0323731335810617 no 191 0.0261523473193514 224 3476986 A myosin inhibitor.
SGTC_232 clozapine 119 µM 1.94034315504143 0.0323923031636268 no 192 0.0261690000060144 273 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_220 paclitaxel 373.376 µM 1.93282524019419 0.0329213424691932 no 193 0.0266288649581481 172 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2437 5741531 144.16 µM 1.92246411963889 0.0336621105988795 no 194 0.0272736920977661 258 2262990
SGTC_786 4544-0069 423 µM 1.91966297438665 0.0338647172937758 no 195 0.0274502419705433 273 748821 YLR208W SEC13
SGTC_3207 9114163 49.47 µM 1.91721412886483 0.0340426629973074 no 196 0.0276053669134165 307 849233
SGTC_2678 equilin 100 µM 1.91127447380103 0.034477464624375 no 197 0.0279846588164385 246 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3178 9107506 49.47 µM 1.91109041344889 0.0344910109753249 no 198 0.0279964814525537 235 8897194
SGTC_1015 4130-4525 82 µM 1.91098545872542 0.034498737320406 no 199 0.0280032248072029 243 1363237
SGTC_2724 maprotiline 69.64 µM 1.90190852727625 0.0351723431652798 no 200 0.0285915570992213 214 4011 A tricyclic antidepressant.
SGTC_729 4092-0585 94.1 µM 1.89925701822515 0.0353711377180621 no 201 0.0287653455925286 242 2169061
SGTC_2859 9028643 45.46 µM 1.89907413454004 0.0353848831627764 no 202 0.028777364690441 206 17151580
SGTC_2240 6690706 185.951 µM 1.89864731854326 0.0354169794776593 no 203 0.0288054312399032 214 805876
SGTC_599 1935-0052 86.5 µM 1.89789367468185 0.0354737113505785 no 204 0.0288550448906898 260 9557311
SGTC_1248 0469-0687 58.6 µM 1.88848577401955 0.036188198360445 no 205 0.0294803829771412 260 4017482
SGTC_1338 1486-1223 76 µM 1.88633515401945 0.0363531719181128 no 206 0.0296249024534246 257 3444526
SGTC_726 3448-4391 34.2 µM 1.87858536301871 0.0369527694827931 no 207 0.0301505656379691 285 1356692
SGTC_1897 st060201 15 µM 1.87831423262371 0.036973892214627 no 208 0.0301690953318622 228 611878
SGTC_160 3453-0671 289.699 µM 1.87498357267635 0.0372341774398973 no 209 0.0303974917570798 281 5322268
SGTC_2892 9047358 58.44 µM 1.86614851586625 0.0379318808710516 no 210 0.031010294899556 190 6466771
SGTC_309 k408-0051 1.48 µM 1.86038746026015 0.0383925499017749 no 211 0.0314153637643524 347 3640463
SGTC_2068 5226020 147 µM 1.85332262944161 0.0389636870877818 no 212 0.0319180647730283 317 1810509
SGTC_3099 9120367 49.47 µM 1.85295186574024 0.0389938505296127 no 213 0.0319446290565213 240 24824940
SGTC_326 k292-0812 17.5 µM 1.84383761861713 0.0397413367154882 no 214 0.032603404258033 209 3579357
SGTC_3272 9137413 49.47 µM 1.84258604067476 0.0398448860754239 no 215 0.0326947367939543 247 17614870
SGTC_1250 0485-0349 40.2 µM 1.84024787875094 0.0400389215500955 no 216 0.0328659268192731 291 6842794 YDL195W SEC31
SGTC_2449 5812982 45.77 µM 1.8370654675255 0.0403042511497156 no 217 0.03310011564231 211 776185
SGTC_728 3030-5151 22.5 µM 1.83326936530555 0.0406226121882314 no 218 0.0333812614021347 245 3125388
SGTC_1710 st031758 61.5 µM 1.83276120043443 0.0406653840393997 no 219 0.0334190457493846 231 5394341
SGTC_144 4161-2749 112.381 µM 1.8312227661593 0.0407950957452416 no 220 0.0335336499959882 225 797501 YMR168C CEP3
SGTC_485 niflumic acid 177 µM 1.82558631669077 0.0412731986779763 no 221 0.0339562992313514 238 4488 A COX2 inhibitor.
SGTC_3192 9110362 49.47 µM 1.81847240653212 0.0418830981639812 no 222 0.0344959802100255 252 16649480
SGTC_1995 st072814 61.1 µM 1.81274666558083 0.0423792679565564 no 223 0.0349354517035521 270 5769371
SGTC_2691 st077356 60.2 µM 1.80935931141181 0.0426750340274521 no 224 0.0351976000385731 295 2839272
SGTC_1437 4092-1038 11.6 µM 1.80901335231445 0.0427053350603355 no 225 0.0352244645043574 288 3977136
SGTC_669 0108-0021 26.2 µM 1.80549964947397 0.0430140711988397 no 226 0.0354982651588509 428 17201
SGTC_2463 5473429 200 µM 1.80035772432472 0.0434691210089155 no 227 0.0359020858122035 249 5399405
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.79379910717668 0.044055176067158 no 228 0.0364226197590716 250 229346 A bile salt which induces apoptosis.
SGTC_1389 3405-0187 19 µM 1.78756202936099 0.0446183935999793 no 229 0.0369233480634931 278 799890
SGTC_207 4185-0010 4.486 µM 1.78477936847301 0.0448715361062807 no 230 0.0371485555621581 376 3761753
SGTC_537 1334-0398 209 µM 1.78470661564416 0.0448781700101043 no 231 0.0371544586494462 300 5846986
SGTC_347 4534-1311 26.2 µM 1.78275063935518 0.045056820186803 no 232 0.0373134520403358 277 2862016
SGTC_2266 7929956 200 µM 1.77677652148609 0.0456060155446045 no 233 0.0378025081457857 320 2967153
SGTC_986 1493-0483 84 µM 1.77220148153066 0.0460302233448242 no 234 0.0381805588949612 262 40079
SGTC_2929 9013348 24.6 µM 1.77162632520683 0.046083776680037 no 235 0.038228303397355 305 2995952
SGTC_215 1287-0124 461.5 µM 1.77094417877665 0.0461473568280372 no 236 0.0382849923939366 198 5560863
SGTC_1312 1218-2183 165 µM 1.76845619273376 0.0463798493809834 no 237 0.0384923347843909 284 6744073
SGTC_444 curcumin 90.4 µM 1.76208570445317 0.0469794344539166 no 238 0.0390274091203585 306 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2580 diallyl disulphide 81.36 µM 1.76155031401268 0.0470301068098292 no 239 0.0390726525029838 293 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2682 pyrogallin 40.03 µM 1.75707949376209 0.0474549632566594 no 240 0.0394521302351175 341 822798 An ATP competetive kinase inhibitor.
SGTC_106 0092-0003 11.579 µM 1.75039942925283 0.0480954851918326 no 241 0.0400247072213111 222 1072148
SGTC_1182 1222-0449 220 µM 1.74433413202709 0.0486830350999419 no 242 0.0405504216257681 284 658318
SGTC_2949 9072542 2.23 µM 1.74054966529602 0.0490525367816607 no 243 0.0408812735983557 366 16457352
SGTC_2904 7225135 42.03 µM 1.74050848945722 0.0490565693277563 no 244 0.0408848853482125 286 4446116
SGTC_3093 9117344 49.47 µM 1.73999798962731 0.0491065870058743 no 245 0.0409296854819387 292 24824913
SGTC_1534 6-azauridine 81.6 µM 1.73674844902685 0.049425925586374 no 246 0.0412157909588447 364 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2334 9017922 200 µM 1.73582817761863 0.0495166630016771 no 247 0.0412971101156507 293 3163164
SGTC_2071 5230951 39.92 µM 1.73378903863605 0.0497181928048705 no 248 0.0414777606276727 318 1799272
SGTC_1029 k015-0030 64.7 µM 1.73006880985662 0.050087551691533 no 249 0.0418089910144425 323 2208316
SGTC_450 aminopyrene 156 nM 1.72872507258898 0.0502214997773587 no 250 0.0419291558876282 341 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_927 2425-1185 123 µM 1.7272922528329 0.0503646422861715 no 251 0.0420575949162854 307 730375
SGTC_2189 6047310 154.431 µM 1.72527792669431 0.0505664284391665 no 252 0.0422386989597506 302 711535
SGTC_9 0092-0002 10.449 µM 1.72443149370316 0.050651412233274 no 253 0.042314988106113 319 759368
SGTC_2502 avocadyne acetate 18.59 µM 1.72001313040336 0.0510968742264317 no 254 0.0427150274221103 385 3952079
SGTC_570 0987-0065 62.6 µM 1.71852507510084 0.0512476007391178 no 255 0.042850442390501 221 3104428
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.71653412936706 0.0514498185037843 no 256 0.0430321634496796 319 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3254 9136651 49.47 µM 1.71308770722232 0.0518013666613421 no 257 0.0433482025992199 342 16454030
SGTC_324 1315-0088 19.6 µM 1.70991137893587 0.0521270522794871 no 258 0.0436411309716975 247 6787421
SGTC_785 1270-0111 65.3 µM 1.70457596610648 0.0526777786269242 no 259 0.0441367684659723 349 6741994
SGTC_679 0422-0091 41.4 µM 1.70309550444317 0.0528314087935009 no 260 0.0442750985561757 369 627384 YHR062C RPP1
SGTC_2803 7707263 71.43 µM 1.70213918850639 0.0529308362234645 no 261 0.0443646395866382 297 2199229
SGTC_2016 5121758 140 µM 1.69614484938481 0.0535574479116756 no 262 0.0449292259229745 383 2795203
SGTC_2622 2-methoxyxanthone 59.94 µM 1.6933027773722 0.0538565874623461 no 263 0.045198924874367 316 71034 A hepatoprotective.
SGTC_3129 9127257 49.47 µM 1.69296503427206 0.0538922240659032 no 264 0.0452310614822196 300 837894
SGTC_2192 5915882 198.485 µM 1.69104465820853 0.0540952055093185 no 265 0.0454141368411405 266 2876149
SGTC_3263 9137018 49.47 µM 1.68645970284686 0.0545822768715704 no 266 0.045853645216791 337 43844957
SGTC_554 4483-2211 187 µM 1.68508531952914 0.0547289547177586 no 267 0.045986055796213 332 747107
SGTC_744 1594-0068 283 µM 1.68202531903937 0.0550566453181758 no 268 0.0462819651827595 396 668392
SGTC_2440 5628896 157.78 µM 1.67947856598569 0.0553305533874065 no 269 0.0465294063704718 311 5522048
SGTC_402 epigallocatechin gallate 10 µM 1.67900320649678 0.0553817981683391 no 270 0.0465757094209268 354 65064 An antioxidant.
SGTC_2059 5238311 157 µM 1.67777450560519 0.0555144284146979 no 271 0.0466955640650443 318 703021
SGTC_2471 5466956 24.79 µM 1.67535113026624 0.0557767508580584 no 272 0.0469326794986512 280 724419
SGTC_2508 celastrol 40.54 µM 1.67429932803084 0.0558909089551994 no 273 0.0470358932570901 286 122724 Celastrol is a natural product and antioxidant.
SGTC_3156 9099931 49.47 µM 1.6724493181418 0.0560921482290868 no 274 0.0472178769665143 320 18111053
SGTC_3115 9123671 49.47 µM 1.67028967826575 0.0563277906400763 no 275 0.0474310321749161 287 3286988
SGTC_2733 amorolfine 100 µM 1.67020266957449 0.0563373006516126 no 276 0.0474396360125461 193 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1708 st033234 31.827 µM 1.66622173822372 0.0567737699481947 no 277 0.0478346288944044 345 674664
SGTC_1703 st026983 48.3 µM 1.66421939215402 0.056994311658622 no 278 0.0480342970575969 335 1104023
SGTC_1473 k844-0725 134 µM 1.66351570832645 0.0570719765405019 no 279 0.0481046245670659 362 54682906
SGTC_2872 9044037 25.97 µM 1.66212509435738 0.057225702203803 no 280 0.0482438474883046 244 6465195
SGTC_1878 temozolomide 1 mM 1.66149087849812 0.0572959198209307 no 281 0.048307449682709 287 5394 DNA alkylating agent.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.65918903542275 0.0575513395890603 no 282 0.0485388531703184 222 279621
SGTC_654 1124-0271 80.9 µM 1.6573733049933 0.0577534499348732 no 283 0.0487220125303331 375 5403748
SGTC_529 4076-0302 30.3 µM 1.65654297780062 0.057846060050852 no 284 0.0488059545406384 358 5816522
SGTC_3222 9128301 49.47 µM 1.65486233895704 0.0580338664993525 no 285 0.0489762126012092 334 4911358
SGTC_17 0960-0276 49.807 µM 1.6541781649637 0.0581104580352409 no 286 0.0490456589941326 393 6821114
SGTC_1354 1498-1681 81 µM 1.65262999890812 0.0582840644895846 no 287 0.0492030944279664 365 5754243
SGTC_2734 clemastine 41.6 µM 1.64622507394027 0.0590066253776068 no 288 0.0498587143989158 180 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_256 clotrimazole 625 nM 1.64443220911523 0.0592101382178635 no 289 0.0500434782643073 348 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_277 nystatin 15.5 µM 1.64312765177354 0.0593585676584807 no 290 0.0501782623884429 361 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1609 st001574 46.4 µM 1.64300682127073 0.0593723302144653 no 291 0.0501907609711732 344 3960012
SGTC_299 1273-0059 1.44 µM 1.63944138928638 0.0597795588798983 no 292 0.0505606838621784 322 2848077
SGTC_630 4356-0227 183 µM 1.6386689082675 0.0598680761570813 no 293 0.0506411163406589 320 779312
SGTC_661 1304-0007 33.6 µM 1.63791690356001 0.0599543456770004 no 294 0.0507195146425508 337 3117130
SGTC_811 0416-0114 265 µM 1.63083718270661 0.060771307148743 no 295 0.0514623396948951 346 6612453
SGTC_2813 7971799 71.43 µM 1.63070896780458 0.060786182315153 no 296 0.0514758717163266 331 2234054
SGTC_1216 1165-0504 9.65 µM 1.62895252483197 0.0609902471567038 no 297 0.0516615347815251 366 6304004
SGTC_3306 9127676 59.7925 µM 1.62675281008473 0.0612465665020706 no 298 0.0518948038567504 356 41905287
SGTC_2877 9040724 71.43 µM 1.61662248364072 0.0624378703710425 no 299 0.0529798978003985 329 6463895
SGTC_321 4534-3890 65.3 µM 1.61563132700189 0.0625553919053086 no 300 0.0530870232987476 327 699746
SGTC_1360 1598-0022 39.8 µM 1.61111590733093 0.0630929691340632 no 301 0.0535772309239266 447 761525
SGTC_2516 gossypol 71.55 µM 1.60482795890213 0.0638475576902765 no 302 0.0542658356007119 373 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_361 000s-0510 1.45 µM 1.60216636807494 0.0641690699712117 no 303 0.0545594125057271 405 660
SGTC_1105 epirubicin 18.1 µM 1.60118657821583 0.0642877420950835 no 304 0.0546678003436342 371 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.59851224089343 0.0646125259596383 no 305 0.0549645116885645 433 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3288 9119690 36.221 µM 1.59360553932599 0.0652117309780154 no 306 0.0555122065147186 329 17595618 YKL019W RAM2
SGTC_3235 9132602 49.47 µM 1.59229656747126 0.0653723085636852 no 307 0.05565904192648 404 4912240
SGTC_2564 betulinic acid 100 µM 1.58657878415269 0.0660773336271919 no 308 0.0563040378269065 431 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2594 a-mangostin 100 µM 1.58042194924103 0.0668430667489956 no 309 0.0570051341274331 413 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2600 tangeritin 87.95 µM 1.57777637396877 0.0671742015195734 no 310 0.0573084966808506 359 68077 A bioactive flavone.
SGTC_2944 9067346 25.62 µM 1.5756874152801 0.0674365621354536 no 311 0.0575489295665226 418 6473075
SGTC_1843 st055809 45.5 µM 1.57446227327984 0.0675908006088226 no 312 0.0576903084228994 356 16413835
SGTC_1963 st076565 50.3 µM 1.56789522586973 0.0684222052828131 no 313 0.0584527930749382 384 4914280
SGTC_1463 k081-0032 34.1 µM 1.56761250853326 0.0684581743726525 no 314 0.0584857955633487 290 977755
SGTC_3345 9148410 3.559 µM 1.5626898701654 0.0690868044571878 no 315 0.0590627790963737 321 4903596
SGTC_934 2950-0684 338 µM 1.5582846959966 0.0696531165959684 no 316 0.0595828875858023 419 1121253
SGTC_965 1291-5240 308 µM 1.55298729370102 0.0703388551864068 no 317 0.0602130851091696 409 2834598
SGTC_1852 st056254 31.4 µM 1.54584430124116 0.0712717062821536 no 318 0.0610710874840251 370 442583
SGTC_2280 7785178 200 µM 1.54548895169677 0.0713183605642685 no 319 0.06111401962495 354 2954328
SGTC_91 0417-1751 58.384 µM 1.54387364826572 0.0715307312885095 no 320 0.0613094725502728 500 6795624
SGTC_3327 9140648 26.9345 µM 1.54148401236795 0.0718457962573781 no 321 0.0615995155241083 373 8029710
SGTC_429 1112-0049 25.5 µM 1.54075085546736 0.0719426734268668 no 322 0.0616887171936868 382 2836170
SGTC_1608 st001473 40.5 µM 1.54029257729335 0.0720032797939856 no 323 0.0617445261445398 402 7292267
SGTC_2900 5328528 85.29 µM 1.53760161729146 0.0723599439013957 no 324 0.0620730258963762 456 795359
SGTC_2275 7947463 200 µM 1.53720801671324 0.0724122256328883 no 325 0.0621211889075854 371 1225414
SGTC_1943 st076331 65.2 µM 1.53647699876469 0.0725094030982541 no 326 0.0622107174123166 390 24208415
SGTC_865 0488-0499 301 µM 1.53533780806602 0.0726610398815522 no 327 0.062350435836318 423 9634651
SGTC_55 0767-0285 6.563 µM 1.53462643133841 0.07275585378406 no 328 0.0624378081614957 456 3116166
SGTC_2762 leflunomide 42.06 µM 1.53238076283466 0.0730557831634896 no 329 0.0627142508818984 448 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1763 st044482 94.5 µM 1.53162895900445 0.0731564045121053 no 330 0.0628070110641742 412 88505
SGTC_1640 st009078 66.4 µM 1.52909692216422 0.0734960721499733 no 331 0.0631202091314952 339 690618
SGTC_1013 4112-3890 241 µM 1.52736128994138 0.0737295994927637 no 332 0.0633355983163137 433 705171
SGTC_2895 9054447 58.44 µM 1.52572402323579 0.0739504113504851 no 333 0.0635393045370906 356 2697450
SGTC_837 0091-0265 12.5 µM 1.52523875777544 0.0740159542168962 no 334 0.0635997783741101 419 759367
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.52237944131956 0.0744030522057336 no 335 0.0639570165451167 420 165521
SGTC_251 melphalan 456.522 µM 1.5153132087705 0.075366316488101 no 336 0.0648465524260194 474 460612 A DNA alkylator.
SGTC_3016 9080866 49.47 µM 1.51262719003504 0.0757349559740094 no 337 0.0651871917869858 432 17066299
SGTC_2715 st079500 56.4 µM 1.50752921231934 0.0764383969681926 no 338 0.0658375309266571 376 28246688
SGTC_1850 st056238 17 µM 1.50720195004291 0.0764837232568912 no 339 0.0658794502916913 463 5393177
SGTC_2160 5660466 132.927 µM 1.50335589420194 0.0770179406167445 no 340 0.0663736468728401 400 2859134
SGTC_2889 9059656 51.95 µM 1.50258422702574 0.0771254659936297 no 341 0.0664731466430416 446 3949838
SGTC_2325 6158266 200 µM 1.50243685142213 0.0771460145203056 no 342 0.0664921625713936 417 3623240
SGTC_1481 3346-2004 36 µM 1.50206793834387 0.0771974701763401 no 343 0.0665397820266203 425 2770522
SGTC_851 0394-0702 453 µM 1.50171086714747 0.0772472989677555 no 344 0.0665858980641878 448 762646
SGTC_1857 st056007 79.3 µM 1.50127918719561 0.0773075719301572 no 345 0.0666416829115436 367 619834
SGTC_1900 st060200 72.8 µM 1.50078376046698 0.077376789504675 no 346 0.0667057501547011 419 688945
SGTC_2134 5324836 1.464 µM 1.49933120574375 0.0775800016724514 no 347 0.0668938653495247 342 699272
SGTC_290 2043-6722 48.1 µM 1.49917056066005 0.0776025007561148 no 348 0.0669146951014414 415 773758 YLR208W SEC13
SGTC_2728 chlorpromazine 9.18 µM 1.49769827127367 0.0778089324794322 no 349 0.0671058306020453 302 2726 A thorazine and dopamine antagonist.
SGTC_2156 5649887 115 µM 1.49752038653465 0.0778339021375213 no 350 0.0671289525067633 477 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3197 9113331 49.47 µM 1.49540998100673 0.078130603725775 no 351 0.067403738633742 454 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1428 4049-0204 61.7 µM 1.49457178369132 0.0782486835146025 no 352 0.0675131173330636 430 X1428
SGTC_2317 5986382 200 µM 1.49456468997584 0.0782496834083499 no 353 0.0675140435966894 399 877883
SGTC_1898 st060199 18.6 µM 1.49313784519276 0.0784510011897975 no 354 0.0677005539229998 400 688866
SGTC_2405 ticlatone 3.52 µM 1.49267558567859 0.0785163069053386 no 355 0.067761063563509 429 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_126 0417-1624 672.48 µM 1.49123203503896 0.0787205098197818 no 356 0.067950292874775 529 41912 YDL195W SEC31
SGTC_1185 1319-0113 81.3 µM 1.49112805350358 0.0787352344450387 no 357 0.0679639391395881 379 4672763
SGTC_483 fpl-64176 144 µM 1.49088054890718 0.0787702914910101 no 358 0.0679964295086849 340 3423
SGTC_660 4031-1742 102 µM 1.48746826979807 0.0792548198244839 no 359 0.0684455887821986 485 6738706
SGTC_22 0964-0034 14.468 µM 1.48713634053332 0.0793020724494879 no 360 0.0684894026019524 479 138402
SGTC_478 N-arachidonylglycine 10 µM 1.48555094726575 0.0795280593328379 no 361 0.0686989690059713 274 5283389
SGTC_979 1426-2828 121 µM 1.48392145251683 0.0797608400743495 no 362 0.068914879962452 479 747872
SGTC_1662 st014054 52 µM 1.48389810856088 0.0797641786052436 no 363 0.0689179768743504 366 2838777
SGTC_2692 st077426 47.7 µM 1.48135333158355 0.080128753507433 no 364 0.0692562219033253 446 25238571
SGTC_2676 harmalol 100 µM 1.47654162166215 0.0808215387510796 no 365 0.0698992751855116 439 5459187 A monoamine oxidase inhibitor
SGTC_2344 7990960 76.95 µM 1.47519888035748 0.0810156700810665 no 366 0.0700795411984144 405 140813
SGTC_2087 5276107 200 µM 1.47113294185787 0.0816056632024039 no 367 0.0706275839186768 412 144405
SGTC_2427 5545055 42.75 µM 1.46959376422897 0.0818298508341315 no 368 0.0708359050796591 467 5372858
SGTC_3182 9108849 49.47 µM 1.46937751051028 0.0818613862440734 no 369 0.0708652118861296 479 17133045
SGTC_286 k060-0067 22.9 µM 1.4675848575405 0.0821231543620671 no 370 0.0711085118339552 424 5985051
SGTC_247 mechlorethamine 29.705 µM 1.46543077942568 0.0824385322557881 no 371 0.0714017124937934 368 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_392 N-ethylmaleimide 8.33 µM 1.46478592759179 0.0825331219329515 no 372 0.0714896662183106 411 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2819 7996655 46.38 µM 1.45866285744937 0.0834353551195732 no 373 0.0723289618862331 389 6456960
SGTC_2020 4017018 200 µM 1.45728901581734 0.0836388048644588 no 374 0.0725183087980895 445 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_933 2914-0560 114 µM 1.45672825156192 0.0837219544730377 no 375 0.072595704016212 491 463887
SGTC_1771 st048882 4.1505 µM 1.45544845084437 0.0839119547109806 no 376 0.072772575706376 422 4580403
SGTC_272 doxorubicin 8.13 µM 1.45495070338147 0.0839859380934658 no 377 0.0728414547117142 499 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1045 1348-1485 165 µM 1.45441559451791 0.0840655293598022 no 378 0.0729155595006088 519 6810614
SGTC_1431 4049-0260 9.09 µM 1.45414801342946 0.0841053501900228 no 379 0.0729526372240237 448 3854841
SGTC_2870 9038528 12.99 µM 1.45165441349719 0.0844771233614385 no 380 0.0732988603665799 408 6463316
SGTC_1574 spiramycin 23.7 µM 1.45141123777068 0.0845134445358305 no 381 0.0733326911802399 464 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1856 st057054 55.7 µM 1.44827108991983 0.0849835157076786 no 382 0.0737706248164677 459 1266018
SGTC_2002 4023503 131 µM 1.44480609527005 0.0855044869350638 no 383 0.0742561792650427 571 4736863 YCR052W RSC6
SGTC_1929 genistein trimethyl ether 50.5 µM 1.44463465883552 0.0855303248202916 no 384 0.0742802661027473 442 136420
SGTC_2959 9079155 11 µM 1.43425452761183 0.0871056732930562 no 385 0.0757498208040436 405 16189457
SGTC_2097 5376186 200 µM 1.42741499801674 0.0881554595236998 no 386 0.0767301551516006 476 742755
SGTC_743 1275-0778 158 µM 1.42688463072899 0.0882372569204366 no 387 0.0768065758013945 492 2849257 YMR203W TOM40
SGTC_1290 0986-0249 10.2 µM 1.42618390542538 0.0883454149923034 no 388 0.076907632064844 412 53329
SGTC_1993 st073995 70.8 µM 1.42579282794541 0.0884058213674053 no 389 0.0769640758822512 456 3098394
SGTC_1553 gossypol 38.6 µM 1.42497660075124 0.0885319961025241 no 390 0.0770819825598696 315 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2713 st079149 53.4 µM 1.42321259667208 0.0888051390754135 no 391 0.0773372675261577 489 3103253
SGTC_2322 7413319 38.22 µM 1.42134695183138 0.0890947026180091 no 392 0.0776079601014467 638 1840400
SGTC_166 k072-0058 166.424 µM 1.4213229214489 0.0890984369108721 no 393 0.077611451435566 469 5846229
SGTC_253 dyclonine 31.25 µM 1.4207440765378 0.0891884239228822 no 394 0.0776955868824912 513 3180 An oral anasthetic.
SGTC_1459 k035-0031 35.7 µM 1.41660579215446 0.0898337309498177 no 395 0.078299107066847 419 3877128 YMR208W ERG12
SGTC_544 k015-0020 52.4 µM 1.41578871847554 0.0899615512822009 no 396 0.0784186868075265 448 3008304
SGTC_2184 6075246 200 µM 1.41536651981769 0.0900276515956513 no 397 0.078480530334271 472 2267320
SGTC_2291 7917025 104.35 µM 1.41416258288901 0.0902163406745083 no 398 0.0786570856797032 500 2964612
SGTC_1403 3909-7815 62.9 µM 1.4101861520404 0.0908416409723794 no 399 0.079242361851282 416 6615483
SGTC_3266 9136860 49.47 µM 1.40732106675365 0.0912941696236084 no 400 0.0796661026034925 493 4871271 YPR165W RHO1
SGTC_1854 st056233 32.9 µM 1.4059420703203 0.0915125714131413 no 401 0.0798706636917403 459 5393174
SGTC_2181 6316240 54.2555 µM 1.4043328672389 0.0917679220162783 no 402 0.0801098757122513 437 12779990
SGTC_1769 st044406 64.4 µM 1.3993412088596 0.0925633630656465 no 403 0.0808553438562633 527 670903
SGTC_3229 9132204 49.47 µM 1.39518254142737 0.0932299491259003 no 404 0.0814804001729261 410 17682924
SGTC_244 nsc-207895 1.295 µM 1.3910600839366 0.0938942254010712 no 405 0.0821036038406929 373 42640
SGTC_2478 5763493 32.33 µM 1.38941393144039 0.0941604535221633 no 406 0.0823534581853806 491 1365576 YLR208W SEC13
SGTC_597 k018-0003 82.8 µM 1.38583566935403 0.0947410769857156 no 407 0.0828985439660487 527 6786234
SGTC_2385 9074692 200 µM 1.38191484829664 0.0953803103149683 no 408 0.0834989241240388 497 17046906
SGTC_414 piperonyl butoxide 100 µM 1.38027568224803 0.0956484918025859 no 409 0.0837508896778762 461 5794 A potent inhibitor of cytochrome P450.
SGTC_85 0868-0259 160.055 µM 1.37951404384019 0.0957732909411168 no 410 0.0838681596211537 476 83173
SGTC_1610 st001799 48.1 µM 1.37722784697866 0.0961486177354785 no 411 0.0842209074331478 414 621897
SGTC_2674 ligustilide 100 µM 1.37606320287475 0.096340233529438 no 412 0.0844010333052326 437 5319022 A signalling regulator.
SGTC_1316 1272-0050 65.9 µM 1.37509906548302 0.0964990726984144 no 413 0.0845503670322452 484 7340392
SGTC_3123 9126162 49.47 µM 1.37360941624262 0.096744866770682 no 414 0.0847814860303958 484 25239884
SGTC_208 k072-0098 12.366 µM 1.37258937294062 0.0969134402602687 no 415 0.0849400187317592 588 5948901
SGTC_306 1672-3436 11.6 µM 1.3697662813908 0.0973811116719243 no 416 0.0853799353917724 508 6797378
SGTC_2309 7664088 163.95 µM 1.36876148880464 0.0975479637751297 no 417 0.085536921312958 558 704922
SGTC_710 3448-4187 58 µM 1.36516345967885 0.0981471585764028 no 418 0.0861008400973352 607 3946412
SGTC_1370 2001-0092 44.6 µM 1.36474544498816 0.0982169467584985 no 419 0.0861665354194133 582 790957
SGTC_254 nsc-64875 3.808 µM 1.36462102299357 0.0982377262161533 no 420 0.0861860968592425 486 56993
SGTC_2614 arthonioic acid 13.39 µM 1.36103001706895 0.0988388410008758 no 421 0.0867521018368232 457 6710684
SGTC_1160 4092-0570 10.5 µM 1.36083563489323 0.0988714561337747 no 422 0.0867828189087495 534 4994975
SGTC_2552 juarezic acid 87.02 µM 1.35896286635673 0.0991860890178691 no 423 0.0870791779572071 581 1549512
SGTC_737 1950-0117 57.9 µM 1.35839150300211 0.0992822260427817 no 424 0.0871697445115326 490 5393513
SGTC_2673 kobusone 100 µM 1.35616895102479 0.0996568383757743 no 425 0.0875227092591386 476 6710676 An epoxy ketone and protein crosslinker.
SGTC_1054 3429-0080 167 µM 1.35612416789837 0.0996643971961583 no 426 0.0875298322389275 540 1162877
SGTC_2183 6420625 130.508 µM 1.3540288789911 0.100018523686117 no 427 0.0878635822202147 605 2897619
SGTC_892 0929-0076 29 µM 1.35391533949764 0.100037739298381 no 428 0.0878816945329272 560 5751038
SGTC_1661 st013063 9.66 µM 1.35296413707163 0.100198828274236 no 429 0.0880335438708519 558 721395
SGTC_545 4218-0007 221 µM 1.35253828591247 0.100271008773762 no 430 0.0881015898367926 499 2840508
SGTC_3056 9094900 49.47 µM 1.3512472424833 0.100490068704574 no 431 0.0883081229040448 493 25236784
SGTC_665 3914-0008 307 µM 1.34989840330198 0.100719307979068 no 432 0.088524286971335 496 1069549
SGTC_1938 st074717 56.4 µM 1.34526665342107 0.101509390939215 no 433 0.0892695691280526 451 17250979
SGTC_1965 Pectolinarigenin 58.4 µM 1.34235835092961 0.1020077900416 no 434 0.0897399160639971 504 5320438 An anti-inflammatory.
SGTC_3353 9151644 39.2805 µM 1.34149421840963 0.10215621999221 no 435 0.0898800228027268 531 4909158
SGTC_3128 9127691 49.47 µM 1.34062731208167 0.102305284208781 no 436 0.0900207425681047 442 41316314
SGTC_1086 cerivastatin 2.18 µM 1.33346460892219 0.103542965026302 no 437 0.0911896910909765 491 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1169 aniline yellow 25.8 µM 1.33345592352939 0.103544472387959 no 438 0.0911911153418202 479 6051 A DNA damaging agent.
SGTC_1146 3579-1023 7 µM 1.33317008820234 0.10359408838151 no 439 0.0912379964858856 584 X1146
SGTC_393 acivicin 6.25 µM 1.32830926896614 0.104440484015338 no 440 0.0920379794634737 479 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_376 3970-0862 59.1 µM 1.3273798610565 0.104602887227257 no 441 0.0921915290611827 538 3135186
SGTC_2716 st080858 38.6235 µM 1.32550744613689 0.104930625270263 no 442 0.0925014506952593 506 5296050
SGTC_1438 4092-1045 4 µM 1.32512858152486 0.104997030146258 no 443 0.0925642539230133 530 1351342
SGTC_1214 0358-0031 63.7 µM 1.32436496427969 0.105130964345712 no 444 0.0926909322676888 536 4301366
SGTC_1611 st001856 99.4 µM 1.32308904941208 0.10535502849874 no 445 0.0929028829605972 502 647478
SGTC_1474 0330-0125 5.35 µM 1.32185767714169 0.105571597887465 no 446 0.0931077739562663 516 X1474
SGTC_631 k072-0230 41.5 µM 1.32184227536096 0.105574308735025 no 447 0.0931103388086361 579 5773147
SGTC_1384 3089-0840 101 µM 1.32085902644208 0.105747473303469 no 448 0.0932741869509412 482 1069836
SGTC_2419 paclitaxel 166.5 µM 1.31863777501239 0.106139423949545 no 449 0.0936451193086621 596 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2259 7964009 200 µM 1.31692435357386 0.106442481741967 no 450 0.0939319911533702 496 313134
SGTC_496 calpeptin 138 µM 1.31452741305454 0.106867483151881 no 451 0.0943343896011213 458 73364 A calpain inhibitor.
SGTC_1953 st076800 12.1 µM 1.31325328421019 0.107093896621344 no 452 0.0945488072099462 569 297591
SGTC_2430 5571206 200 µM 1.31019891367342 0.107638068340891 no 453 0.0950642765751566 603 1731771
SGTC_3296 9122258 64.045 µM 1.30452307290316 0.108654570860377 no 454 0.0960276489509093 549 4730474
SGTC_539 4859-0462 2.54 µM 1.30317594871551 0.108896841699143 no 455 0.096257349641045 540 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1249 0481-0015 10.2 µM 1.30254626964875 0.109010218156487 no 456 0.0963648558082373 479 4227577
SGTC_2211 7117706 200 µM 1.3023579378834 0.109044144587878 no 457 0.0963970271433889 508 822771
SGTC_283 0987-0079 11.7 µM 1.29822104672747 0.109791286794989 no 458 0.0971056939258758 585 411556
SGTC_2424 5537928 59.2 µM 1.29715838779696 0.109983799829473 no 459 0.0972883475635438 607 5382802
SGTC_3122 9126309 49.47 µM 1.29686644437748 0.110036731164692 no 460 0.0973385719593088 510 17591206
SGTC_1090 efavirenz 20.7 µM 1.29456740725468 0.110454201051658 no 461 0.0977347509525965 541 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_783 0848-0141 92.7 µM 1.29292795453869 0.110752593307774 no 462 0.0980179890186193 519 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1436 4092-1007 8.32 µM 1.29168040098049 0.110980043777659 no 463 0.0982339237571174 518 2881121
SGTC_342 k048-0088 23.3 µM 1.29032669640859 0.111227225679172 no 464 0.0984686257694424 548 6820570
SGTC_1181 1222-0449 220 µM 1.28501854048325 0.112200279711151 no 465 0.0993929025971199 552 658318
SGTC_2529 gangaleoidin 93.61 µM 1.28145283702578 0.112857326483576 no 466 0.10001732778652 549 4565183
SGTC_3121 9125696 49.47 µM 1.28024207286878 0.113081055641121 no 467 0.100230006657158 507 1235365
SGTC_771 0250-0039 27.3 µM 1.27805059799729 0.113486808404728 no 468 0.100615793105534 554 3005115
SGTC_3068 9116768 49.47 µM 1.27726304839971 0.113632876924699 no 469 0.100754697287072 516 41904888
SGTC_1787 fluconazole 80 µM 1.27715558479459 0.113652818818467 no 470 0.100773662034953 621 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1186 1319-0216 26 µM 1.27154753805 0.114696961807727 no 471 0.101766963390023 605 4565136
SGTC_2760 etidronate 98.04 µM 1.26970564280412 0.115041382445642 no 472 0.102094751021256 543 3305 A chelator and antioxidant.
SGTC_1205 4161-2785 76 µM 1.26880979185654 0.115209165466957 no 473 0.102254455956301 498 3498106
SGTC_3299 9121982 43.1275 µM 1.26818477276102 0.115326327641755 no 474 0.10236598678031 576 17594604 YPL160W CDC60
SGTC_2950 9072895 21.46 µM 1.26723830060537 0.115503908576711 no 475 0.102535047302676 590 17332245
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.26697850066775 0.115552687259505 no 476 0.102581488711052 624 23847180
SGTC_3317 9138495 8.753 µM 1.26588977734082 0.115757259452811 no 477 0.10277627340432 598 17020139
SGTC_624 k048-0052 28 µM 1.26298280139156 0.116304743037714 no 478 0.103297680306835 554 6835531
SGTC_2072 5231554 129 µM 1.26277271559974 0.116344380486162 no 479 0.103335436417374 564 789545
SGTC_1425 4048-4433 7.33 µM 1.26175454257607 0.11653661769497 no 480 0.103518561953011 614 23734946
SGTC_1939 st074455 53.6 µM 1.260386566826 0.116795254279283 no 481 0.103764972592956 591 1644229
SGTC_3350 9150499 3.57 µM 1.25872071833844 0.117110757361341 no 482 0.104065612648401 634 4910996 YPR165W RHO1
SGTC_307 1501-1223 22.3 µM 1.25775589095001 0.117293766583932 no 483 0.104240026143219 575 2830329
SGTC_1381 2324-0066 62.1 µM 1.25657373735896 0.117518274429584 no 484 0.104454014786924 561 10885928
SGTC_908 3448-7491 47.7 µM 1.25455771040552 0.117901848242915 no 485 0.104819681727174 671 1203031
SGTC_1164 k060-0068 93.7 µM 1.25279332250298 0.118238270761749 no 486 0.105140466209322 624 5963676
SGTC_3191 9110352 49.47 µM 1.25093305546949 0.118593709401984 no 487 0.105479451307894 544 17122424
SGTC_2534 helenine 20.12 µM 1.24813410499668 0.11912992249857 no 488 0.105990975234035 526 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_981 1488-1094 54.9 µM 1.24645017514768 0.119453347278853 no 489 0.106299585198196 520 3449522
SGTC_2115 tiliquinol 12.7705 µM 1.24198581341872 0.120313793860063 no 490 0.107120898171386 553 71208 A bioactive hydroxyquinoline.
SGTC_2144 5628481 200 µM 1.24090223703831 0.12052329570721 no 491 0.107320933135537 533 2818399
SGTC_72 0744-0168 198.391 µM 1.23709299071204 0.12126182503309 no 492 0.108026280841131 582 677577
SGTC_2686 alizarin 95.37 µM 1.23706747394434 0.121266782882025 no 493 0.10803101693875 551 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1052 3253-3998 198 µM 1.23633021309822 0.121410092523873 no 494 0.108167922482064 639 5450317
SGTC_2990 9074105 71.4286 µM 1.23493346026495 0.121681921385547 no 495 0.108427634633673 543 6502001
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.23301542413981 0.122055896184765 no 496 0.108785004817838 482 1241132 A phosphatase inhibitor.
SGTC_468 gf-109203x 121 µM 1.23059557311759 0.122528864363967 no 497 0.109237080885058 437 2396 A protein kinase C inhibitor.
SGTC_3188 9110789 49.47 µM 1.22964604416491 0.122714803896696 no 498 0.109414839921708 615 849217
SGTC_2413 inermin 26.06 µM 1.22872488668375 0.122895376692408 no 499 0.109587486057459 620 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_875 0709-0210 25.7 µM 1.22684160414773 0.12326513271612 no 500 0.109941065169243 644 6251364
SGTC_1382 3002-2117 298 µM 1.22682844399743 0.123267719266185 no 501 0.109943538814131 637 1497314
SGTC_1067 clotrimazole 1.36 µM 1.22540014420143 0.123548669265913 no 502 0.110212246317656 633 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2992 9074591 71.4286 µM 1.22523625200814 0.123580935913286 no 503 0.110243109623891 586 17741321
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.2240819254663 0.123808363733663 no 504 0.110460661846349 632 5393153
SGTC_1021 4476-0760 85.3 µM 1.22222199487889 0.124175427206077 no 505 0.110811844204302 598 746768
SGTC_401 neomycin 50 µM 1.22220690215701 0.124178408915471 no 506 0.110814697201302 558 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_975 1335-0046 28.5 µM 1.21972183381952 0.124670040794845 no 507 0.111285170890853 591 16486740
SGTC_3023 9089636 49.47 µM 1.21935488088847 0.124742751804038 no 508 0.111354763484848 643 17249241
SGTC_2035 5154463 94.595 µM 1.21557867717495 0.12549272115258 no 509 0.112072730443684 618 2769623
SGTC_113 0099-0221 2.5 µM 1.21430536410478 0.125746314271691 no 510 0.11231556902338 586 89219
SGTC_1728 st035614 33.7865 µM 1.21343306495984 0.125920247628499 no 511 0.112482145524156 674 15945546
SGTC_20 0481-0013 4.944 µM 1.21278127946085 0.126050320814896 no 512 0.112606727319142 595 182045
SGTC_3112 9123419 49.47 µM 1.21215116959335 0.126176157344904 no 513 0.112727259707372 634 17015854
SGTC_481 bay k-8644 50 µM 1.208999353076 0.126806907374233 no 514 0.113331546958109 572 2303 A calcium channel antagonist.
SGTC_1097 itavastatin 7.23 µM 1.20586564844466 0.127436205921701 no 515 0.113934648878191 633 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_366 0181-0206 4.31 µM 1.20442420772822 0.127726398583693 no 516 0.1142128300913 641 274874
SGTC_1930 st074634 34.3 µM 1.19830359812368 0.128963721738977 no 517 0.115399423173899 631 684253 YOR116C RPO31
SGTC_2799 7812892 81.82 µM 1.19686409301867 0.129255930961991 no 518 0.115679765830102 664 20205235
SGTC_982 1491-0518 27.5 µM 1.1944855783154 0.129739757387803 no 519 0.116144039372402 574 3091256
SGTC_2875 9039966 71.43 µM 1.19401605596318 0.129835413480415 no 520 0.116235843739619 569 6463691
SGTC_3072 9116419 49.47 µM 1.1938400257501 0.129871288812514 no 521 0.116270275693651 547 17170162
SGTC_694 1315-0438 43.2 µM 1.19193851084985 0.13025925911546 no 522 0.116642678205606 537 6793154
SGTC_1892 st058411 7.36 µM 1.19001916017416 0.130651680938471 no 523 0.11701943069905 692 3934738
SGTC_2224 6650123 117.647 µM 1.18638812796705 0.131396299444149 no 524 0.117734528976734 590 2908370
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.18429041166408 0.131827812532947 no 525 0.118149061529279 879 16725076
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.18313228052752 0.13206646561421 no 526 0.118378363115959 632 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.18280032006924 0.132134926748362 no 527 0.118444146855942 607 6708760
SGTC_614 0462-0418 107 µM 1.18095309922198 0.132516331173702 no 528 0.118810677741222 561 5188303
SGTC_962 1254-0300 21.5 µM 1.1800213442317 0.132709002562139 no 529 0.118995862928157 631 7340576
SGTC_1770 st043884 66.3 µM 1.17946767571772 0.132823583321801 no 530 0.119106000371948 642 670149
SGTC_369 0957-0393 4.5 µM 1.17898333102923 0.132923873481968 no 531 0.119202406705118 573 6997992
SGTC_431 k089-0097 107 µM 1.17639236223704 0.133461254184947 no 532 0.119719061208315 703 5499420
SGTC_3283 9109332 35.8195 µM 1.16990690879192 0.134812916518883 no 533 0.121019216652875 543 17027281
SGTC_2679 rapamycin 1 nM 1.16973882890855 0.134848071213889 no 534 0.121053043610843 736 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1450 4112-4260 37.6 µM 1.16698786010777 0.135424343138569 no 535 0.121607636077291 672 1633175
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.16456232867774 0.13593384072126 no 536 0.122098099985771 621 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2044 5102272 200 µM 1.16099643588099 0.136685258489203 no 537 0.122821674435354 598 592666
SGTC_1087 pterostilbene 9.05 µM 1.15950232015713 0.137000946637822 no 538 0.123125745673867 682 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3277 9138724 49.47 µM 1.15726068073088 0.137475511119494 no 539 0.123582936310522 542 15943418
SGTC_2311 7694451 200 µM 1.1556905194735 0.137808588474834 no 540 0.123903883695323 648 2163142
SGTC_1629 st005085 44.9 µM 1.15237012695936 0.138514753403576 no 541 0.124584505574081 647 24207091
SGTC_1337 1486-1011 40.3 µM 1.15186679653131 0.138622014101946 no 542 0.124687907114988 648 X1337
SGTC_549 1661-1316 519 µM 1.15127415729941 0.138748379199775 no 543 0.124809732655543 677 2857282
SGTC_1401 3807-4679 7.6 µM 1.14852564221457 0.139335454982954 no 544 0.125375816812403 622 3291456
SGTC_565 1418-0001 44.5 µM 1.14355877268091 0.14040064690202 no 545 0.126403333786937 707 2862145
SGTC_880 0833-0487 87.2 µM 1.1399836889074 0.141170770957463 no 546 0.127146548322041 655 76075
SGTC_798 1287-0182 476 µM 1.13975539080017 0.141220046731188 no 547 0.127194111669168 739 1649755
SGTC_1477 0139-0234 16 µM 1.13694708206791 0.141827144948291 no 548 0.127780204095792 675 620880
SGTC_2398 5228213 48.84 µM 1.13463195807492 0.142328954042437 no 549 0.128264778573552 772 80771 YMR134W ERG29
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.13452910786407 0.142351274923923 no 550 0.128286335531526 725 165506
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.13360558714699 0.142551806442647 no 551 0.128480014180147 715 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2075 5212009 200 µM 1.1273090097728 0.143924123569755 no 552 0.129805927189677 596 780898
SGTC_2196 6573537 42.6665 µM 1.12483230026025 0.144466347741552 no 553 0.130330052146949 671 2903087
SGTC_1947 st076332 61.6 µM 1.12265053379898 0.144945139221594 no 554 0.130792972151932 630 24208416
SGTC_606 k015-0008 38.6 µM 1.12230398894676 0.145021287143568 no 555 0.130866605360021 757 1970475
SGTC_502 l-744,832 89.3 µM 1.11808481052367 0.145950546620232 no 556 0.131765386548789 706 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2095 5432005 200 µM 1.1178431925959 0.146003882988776 no 557 0.131816985295347 650 783734
SGTC_2890 9046729 58.44 µM 1.11519154634582 0.146590085696927 no 558 0.132384173950442 622 903329
SGTC_2971 9092186 9.93 µM 1.11480310071598 0.146676092313041 no 559 0.132467403726048 628 25236400
SGTC_2172 5754775 163.918 µM 1.11427544855014 0.146792975186357 no 560 0.132580518144834 633 2263357
SGTC_2141 5621638 7.665 µM 1.11319156475875 0.147033267674621 no 561 0.132813082338656 689 2856238
SGTC_2731 amoxapine 43.43 µM 1.11302955650058 0.147069206871634 no 562 0.132847867858969 587 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_730 1436-0052 41.2 µM 1.11255617802034 0.147174252812244 no 563 0.132949545021893 655 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_735 3076-0345 636 µM 1.1117639815668 0.147350159149893 no 564 0.133119821057639 753 2888990
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.11063857100743 0.147600297476337 no 565 0.133361976666346 640 17037758
SGTC_2046 4110841 106 µM 1.10956772924419 0.147838571053261 no 566 0.1335926718502 695 44119630 YMR134W ERG29
SGTC_3206 9114350 49.47 µM 1.10789722884472 0.148210788974105 no 567 0.133953101264943 652 17087243
SGTC_2475 5812728 15.03 µM 1.10666791544657 0.14848510253779 no 568 0.13421876602499 718 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2109 5483026 200 µM 1.10490783736785 0.148878443588202 no 569 0.134599763036658 725 759335
SGTC_1467 k284-1082 293 µM 1.10406015170729 0.149068131993501 no 570 0.134783522733763 746 3334705
SGTC_2416 tofa 880 nM 1.10142839067313 0.149658074950632 no 571 0.13535512737237 632 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2473 5854593 8.94 µM 1.10034338415008 0.149901745950414 no 572 0.135591268089563 674 2872951
SGTC_2338 7999974 200 µM 1.09934392998355 0.150126437572651 no 573 0.135809038803209 776 315925
SGTC_2100 5377183 190 µM 1.09807318253395 0.150412443851761 no 574 0.13608626722236 760 2844202
SGTC_913 3487-1245 167 µM 1.09734019895665 0.150577580957147 no 575 0.136246352199087 689 4016153
SGTC_2244 6635614 200 µM 1.09504308049576 0.151095890870844 no 576 0.13674888164095 558 836499
SGTC_1397 3532-0190 20.1 µM 1.09456684973046 0.151203493501473 no 577 0.13685322271076 627 5322280
SGTC_2732 terfenadine 20 µM 1.0942224908111 0.15128133191186 no 578 0.136928704853198 661 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1738 st035555 74 µM 1.09382167145368 0.151371966120892 no 579 0.137016598731352 713 5331140
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.09295064557847 0.151569049003073 no 580 0.137207734978776 763 6708784 An antioxidant flavonoid
SGTC_3146 9095609 49.47 µM 1.09049664596995 0.152125220729727 no 581 0.137747214983449 724 17173999
SGTC_1819 st053448 58.6 µM 1.08948762725397 0.152354296287353 no 582 0.137969454035829 709 2857616
SGTC_504 lovastatin 124 µM 1.08948577164709 0.152354717772989 no 583 0.137969862963343 639 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.08735401664267 0.152839439354364 no 584 0.138440192426213 691 115019
SGTC_44 0929-0055 61.211 µM 1.08699815700864 0.152920454738935 no 585 0.138518812095423 653 1379590
SGTC_2180 6301957 200 µM 1.08407160690765 0.1535877960549 no 586 0.139166525362166 738 845462
SGTC_505 gw-5074 63.9 µM 1.08320492473792 0.153785795180003 no 587 0.139358737154664 728 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1774 st048371 48.465 µM 1.07818337016913 0.154936325893819 no 588 0.14047596589921 737 4242727
SGTC_2553 4-methylesculetin 85.09 µM 1.07647523011215 0.155328984743439 no 589 0.140857386477915 725 5319502
SGTC_1155 4088-0394 48.2 µM 1.07149232685565 0.156478179185039 no 590 0.14197405950351 719 2326248
SGTC_1039 k821-0043 94 µM 1.07069686340727 0.156662151812255 no 591 0.142152876792664 754 15992768
SGTC_3307 9126885 69.2785 µM 1.06774238647844 0.157346701173365 no 592 0.142818366464053 751 24824909
SGTC_2810 7959871 45.46 µM 1.06760224705184 0.157379220111127 no 593 0.142849984800203 782 2974535
SGTC_795 0685-0265 78 µM 1.06508564731806 0.157963941534987 no 594 0.143418586821169 755 302754
SGTC_38 0929-0051 58.268 µM 1.06432851666617 0.158140136436307 no 595 0.143589951980602 799 1379719
SGTC_420 mitomycin C 81.9 mM 1.06413867690116 0.158184335025362 no 596 0.143632941023506 733 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_953 1188-0045 9.7 µM 1.06246624552222 0.158574061613896 no 597 0.144012036913937 751 6144426
SGTC_1080 nisoldipine 24.4 µM 1.06221243988681 0.15863326091025 no 598 0.144069626847436 754 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3138 9097216 49.47 µM 1.06118535649335 0.158872972557369 no 599 0.144302836443897 745 25237486
SGTC_2956 9076196 2.52 µM 1.06035959821653 0.159065868880792 no 600 0.144490517579123 734 16423868
SGTC_627 1391-0720 175 µM 1.05839300348381 0.159525881079641 no 601 0.144938153926003 714 997839
SGTC_2396 5342950 42.78 µM 1.05591992021676 0.16010560239202 no 602 0.145502401175888 771 1886677
SGTC_1588 farnesol 29.9 µM 1.05565328256645 0.1601681877117 no 603 0.145563324093236 751 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2231 micatex 6.853 µM 1.05310888805125 0.160766213599434 no 604 0.146145544888777 719 20737 An antifungal of unknown mechanism.
SGTC_1519 esterone 74 µM 1.05230164080654 0.160956250532962 no 605 0.146330589563202 740 698 A steroid.
SGTC_2842 9000675 19.48 µM 1.05145071402487 0.161156728895142 no 606 0.146525817115012 683 2989072
SGTC_1906 st060206 94.7 µM 1.05062352371003 0.161351771046006 no 607 0.14671576633106 803 5133468
SGTC_3168 9103419 49.47 µM 1.04848136800873 0.161857582492118 no 608 0.147208441098768 676 16649256
SGTC_62 0180-0423 3.232 µM 1.04834995051626 0.161888646734827 no 609 0.14723870189408 744 30102 YGL099W LSG1
SGTC_2049 5262831 67.185 µM 1.04516585219854 0.162642485521155 no 610 0.147973161413044 751 763417
SGTC_2506 ethyl hematommate 54.16 µM 1.04458239926346 0.162780865809207 no 611 0.148108008883013 684 3940691 An allergen.
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.0441452133057 0.162884605436676 no 612 0.14820910505127 844 65057 A dermal irritant. YDR527W RBA50
SGTC_1775 st081588 35.1725 µM 1.04378894825157 0.162969175167525 no 613 0.148291522965773 794 1426443 YGL099W LSG1
SGTC_1077 5-fluorocytosine 377 nM 1.04310037390458 0.163132708930275 no 614 0.148450903778066 734 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2332 7982454 138.89 µM 1.04304415318868 0.163146065842109 no 615 0.148463921958723 769 2981748
SGTC_1923 st058458 19.1 µM 1.04286790018386 0.163187944619307 no 616 0.14850473914889 814 3534982
SGTC_2055 5235184 200 µM 1.04264543659472 0.163240813282408 no 617 0.148556268634302 741 2836034
SGTC_629 3448-6466 76.7 µM 1.04217313169726 0.163353093838924 no 618 0.148665708765862 769 573744
SGTC_2735 sertaconazole 140 nM 1.03914653773122 0.164073793411789 no 619 0.149368295048046 726 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_371 0195-0006 7.36 µM 1.03896827149122 0.164116306807147 no 620 0.149409746358029 676 3928593
SGTC_1335 1486-0900 202 µM 1.0386474091415 0.164192844895264 no 621 0.149484374137486 774 X1335
SGTC_2007 4011539 71.82 µM 1.03308769625179 0.165522726401955 no 622 0.150781430338401 761 45595301
SGTC_1604 st002052 72.4 µM 1.03223970207366 0.165726177007825 no 623 0.150979920211432 760 6254834 YHR062C RPP1
SGTC_105 0111-0055 734.78 µM 1.03220222449056 0.165735172351777 no 624 0.150988696594562 677 5179370
SGTC_1153 4055-0057 267 µM 1.03213414750932 0.165751512949898 no 625 0.15100463951748 781 882706
SGTC_580 1123-0028 41 µM 1.03188160478939 0.16581214017562 no 626 0.15106379218938 853 1677248 YPR107C YTH1
SGTC_867 0518-0118 155 µM 1.03136196428355 0.165936933910198 no 627 0.151185555240457 776 6848158
SGTC_900 1112-0045 141 µM 1.02793169010928 0.166762250298022 no 628 0.151990980711358 640 56211 YIL048W NEO1
SGTC_609 0986-0026 86.3 µM 1.0267745581282 0.167041250067302 no 629 0.152263316015132 789 2848610
SGTC_2952 9073731 13.78 µM 1.02556552314286 0.167333085698317 no 630 0.152548212750192 806 16457353
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.02392137819162 0.167730474645446 no 631 0.152936205884421 773 5379071
SGTC_1465 k213-0056 144 µM 1.02170340079827 0.168267520646786 no 632 0.153460650516859 759 24048857 YMR208W ERG12
SGTC_3120 9124077 49.47 µM 1.02109018043684 0.168416196631673 no 633 0.153605857488774 811 18774327 YGL155W CDC43
SGTC_918 glabranin 770.725 nM 1.01910809337617 0.168897333532651 no 634 0.154075826137891 783 124049 Also referred to as licorice root.
SGTC_1472 k841-0093 193 µM 1.01472728952812 0.169963870383928 no 635 0.155117920953426 821 X1472
SGTC_1761 st044296 37 µM 1.01380568563026 0.170188789679929 no 636 0.15533774088828 767 1826700
SGTC_2876 9059903 25.97 µM 1.01050120099574 0.170996822864555 no 637 0.156127612161228 835 6916095
SGTC_1440 4100-1550 40 µM 1.00935492110884 0.171277690748773 no 638 0.156402224718196 789 742806
SGTC_1803 st050068 52.4 µM 1.00861789239135 0.171458437332252 no 639 0.156578961503931 934 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_681 1642-0006 26.6 µM 1.00435791825667 0.172505527185843 no 640 0.157603062973873 775 4446530
SGTC_1147 3809-1045 12.3 µM 1.00379223629696 0.172644876327335 no 641 0.157739383660252 767 325925
SGTC_1082 camptothecin 424.86 nM 1.00068602858069 0.173411332807414 no 642 0.158489312038714 703 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1734 st037168 69.4 µM 0.999043887598071 0.173817404817241 no 643 0.158886715740938 777 708907
SGTC_2267 7931562 200 µM 0.999022938710526 0.17382258900517 no 644 0.158891789658079 718 934880
SGTC_675 1309-0189 238 µM 0.99840558062242 0.173975409781465 no 645 0.159041364309047 769 4246530
SGTC_2567 aureobasidin a 60 nM 0.997838603537606 0.174115834477683 no 646 0.159178813798408 777 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_49 0717-0965 32.132 µM 0.996247350599052 0.174510328964581 no 647 0.159564988983415 822 5889349 YGL099W LSG1
SGTC_2421 5690543 90.72 µM 0.994647524354848 0.174907520694939 no 648 0.159953862433821 805 3397993
SGTC_3315 9136395 68.55 µM 0.994641424805078 0.174909036138071 no 649 0.159955346250509 862 16876844
SGTC_587 k089-0003 57 µM 0.993058661789988 0.175302557790818 no 650 0.160340683858425 696 9659696
SGTC_141 0443-0274 32.331 µM 0.992418084628862 0.17546198365934 no 651 0.160496810317186 914 1627241
SGTC_1005 4092-0690 4.4 µM 0.992196971673339 0.175517035244948 no 652 0.16055072474036 748 1529343
SGTC_3273 9137859 49.47 µM 0.991327672540061 0.17573357505593 no 653 0.16076280239595 815 2377234
SGTC_2976 9009005 19.48 µM 0.988259907671375 0.176499097865553 no 654 0.161512687578579 835 2993148
SGTC_1172 0370-0043 85 µM 0.987762600797625 0.176623393035712 no 655 0.161634463863967 804 376585
SGTC_1762 st045503 25.4615 µM 0.984578927770747 0.177420420227115 no 656 0.162415472272507 825 4645554
SGTC_137 0438-0332 85.389 µM 0.983069689444855 0.177799047582771 no 657 0.162786570470147 882 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3180 9109287 49.47 µM 0.97934500331956 0.178735650493855 no 658 0.163704770608574 770 18891271
SGTC_2507 purpurin 79.67 µM 0.978353804003456 0.178985418055907 no 659 0.163949683849192 818 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_317 4495-0002 170 µM 0.971857949804344 0.180627708756761 no 660 0.165560610870057 779 15991618
SGTC_3252 9135871 49.47 µM 0.971638345324165 0.18068339408904 no 661 0.165615249565884 823 17682838
SGTC_1165 k072-0275 30.3 µM 0.969795629548009 0.181151077431536 no 662 0.166074185880133 817 6153523 YGL055W OLE1
SGTC_2148 5546263 113.568 µM 0.969111245031675 0.181324967935022 no 663 0.166244843853904 822 792097
SGTC_343 4130-2827 29.8 µM 0.968592881700713 0.181456744809368 no 664 0.166374178178234 841 1118244
SGTC_138 0850-0259 40.9225 µM 0.967797718496902 0.181659005456045 no 665 0.166572701736987 903 6813004
SGTC_107 0358-0022 2.6945 µM 0.967308991177623 0.181783389911252 no 666 0.16669479514895 715 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_598 3937-0236 20.2 µM 0.966734177682672 0.181929752052532 no 667 0.166838468413468 898 1379313
SGTC_2666 tannic acid 100 µM 0.966453016760453 0.182001369609118 no 668 0.166908773001327 869 16134267 A thiamine antagonist.
SGTC_2056 5235370 200 µM 0.965457971315469 0.182254970020451 no 669 0.167157738633931 787 5511916
SGTC_2942 9052777 62.25 µM 0.961414301803283 0.183287822924937 no 670 0.16817194803937 905 6469503
SGTC_123 0083-0120 66.675 µM 0.959168857480816 0.183862937771855 no 671 0.16873684321752 818 16001701
SGTC_170 4197-0004 226 µM 0.959016338902549 0.183902042342116 no 672 0.168775257086822 778 218692
SGTC_1937 st074714 47.2 µM 0.95680862114686 0.184468663887323 no 673 0.169331930013135 825 17250970
SGTC_2585 alliin 100 µM 0.955922925289797 0.184696286945345 no 674 0.16955558784175 849 87310 A garlic compound which reacts with lipids.
SGTC_2367 9070478 135.38 µM 0.955727679232146 0.184746488491315 no 675 0.169604917281582 835 572802
SGTC_717 1532-0246 73.2 µM 0.954305987766756 0.185112288633009 no 676 0.169964388997456 832 9561992
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.951469834716837 0.185843371529976 no 677 0.170682962214732 896 6708561
SGTC_642 0335-0876 158 µM 0.951263426966741 0.185896647631031 no 678 0.170735333885729 851 6812350
SGTC_925 2064-1272 59.6 µM 0.950168275384387 0.186179476658392 no 679 0.17101337784031 797 6815817
SGTC_2484 5809818 12.04 µM 0.949082034617029 0.186460267702355 no 680 0.171289445414963 826 2870548
SGTC_2998 9066762 71.4286 µM 0.945633412945838 0.187353466411027 no 681 0.172167797922421 873 4945196
SGTC_817 1391-0715 46 µM 0.944643935384358 0.187610230268108 no 682 0.172420344322344 819 1353946
SGTC_441 propafenone 146 µM 0.944508557255034 0.187645377030923 no 683 0.172454915528555 830 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1649 st011737 51.3 µM 0.944335143504662 0.1876904045139 no 684 0.172499206263455 845 1761035
SGTC_154 3389-1638 511.116 µM 0.944224986415956 0.187719010651132 no 685 0.172527344699497 754 5238686
SGTC_701 4424-0219 185 µM 0.94279706403689 0.188090064270814 no 686 0.172892356876666 937 2911779
SGTC_2285 7945142 200 µM 0.94036671882565 0.18872264313461 no 687 0.173514743697712 811 2970608
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.93638504008 0.189761838597409 no 688 0.174537488778549 865 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.934849753662495 0.190163477887 no 689 0.174932867356745 882 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2261 9010538 184.68 µM 0.934367683478604 0.190289697749372 no 690 0.175057130874061 752 6457250
SGTC_1951 sophoraflavanone G 9.2 µM 0.934128089441481 0.190352449511516 no 691 0.175118911998558 865 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2372 9071633 200 µM 0.933542397638575 0.190505900790672 no 692 0.175269995254926 942 21321366
SGTC_985 1493-0307 8.71 µM 0.93294448201448 0.190662633034975 no 693 0.175424316965488 843 3278274
SGTC_1194 1488-0194 225 µM 0.929482175626748 0.191571766207232 no 694 0.176319629180103 889 1391452
SGTC_1789 tunicamycin 25 nM 0.927441384185785 0.192108879454009 no 695 0.176848706073449 877 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2030 5175110 200 µM 0.927334628555477 0.192137001666732 no 696 0.176876410150913 867 2831986
SGTC_1305 1181-0477 144 µM 0.920035208816362 0.194065828340045 no 697 0.17877718018197 889 6252086
SGTC_3208 9114115 49.47 µM 0.919484106653242 0.194211931068595 no 698 0.178921207466399 787 650895
SGTC_1901 st060216 58.6 µM 0.918177177235448 0.19455867891656 no 699 0.179263057550497 902 688792
SGTC_887 0885-0007 9.62 µM 0.917796211472961 0.194659825685303 no 700 0.179362783028321 906 5719458
SGTC_1190 1486-1332 13 µM 0.917259866240994 0.194802280066188 no 701 0.179503241329657 891 4150046
SGTC_2 0422-0095 29 µM 0.914613013029703 0.195506217787362 no 702 0.180197412369328 780 6790840
SGTC_890 0929-0006 47.2 µM 0.913536046422665 0.19579308155075 no 703 0.180480342224981 874 1378169
SGTC_2271 7849410 118.62 µM 0.911958194347668 0.196213823545912 no 704 0.180895362573469 891 972430
SGTC_503 tyrphostin 8 294 µM 0.911001403774491 0.196469223246303 no 705 0.181147317013841 895 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1107 amlodipine 47 µM 0.910545701368768 0.196590936393574 no 706 0.181267395695778 856 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2826 7992541 19.48 µM 0.909206391194434 0.196948915879951 no 707 0.18162059560413 894 2985066
SGTC_3094 9117742 49.47 µM 0.909192224229723 0.196952704625805 no 708 0.181624333985024 967 17149698
SGTC_3198 9112019 49.47 µM 0.909175729414418 0.196957115976573 no 709 0.181628686700173 887 45595555
SGTC_1317 1273-0028 910 nM 0.908400468168408 0.197164518242769 no 710 0.181833339241823 913 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.908379501849353 0.197170129105453 no 711 0.181838875908186 833 6857784
SGTC_3245 9134821 49.47 µM 0.905643629766977 0.197903113031013 no 712 0.182562253935859 933 17014901
SGTC_2318 6029776 164 µM 0.903410872345482 0.198502522571331 no 713 0.183153935899861 898 818325
SGTC_3043 9092303 49.47 µM 0.902573872457446 0.198727506810266 no 714 0.183376049238459 861 25236084
SGTC_922 1866-0035 480 µM 0.90124281678973 0.199085608971766 no 715 0.183729615093914 989 3156169
SGTC_548 1436-0017 110 µM 0.900471477776011 0.199293304897283 no 716 0.183934698682585 988 9677137
SGTC_1956 st077085 54 µM 0.899057615586393 0.19967434955659 no 717 0.184310986270134 932 24208685
SGTC_97 0535-0701 19.132 µM 0.8965671212323 0.200346618489863 no 718 0.184974974483109 846 2832013 YGL099W LSG1
SGTC_833 3852-0053 558 µM 0.893022059443022 0.201305892907482 no 719 0.185922679747862 974 3123681
SGTC_177 1327-0068 8.361 µM 0.89188017120481 0.201615466972055 no 720 0.186228581959044 924 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2323 6148992 148.28 µM 0.89000878026097 0.202123430688174 no 721 0.186730585744731 822 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2814 7977482 42.97 µM 0.889875294598492 0.202159692798674 no 722 0.18676642547731 966 6456762
SGTC_1862 st057513 3.81 µM 0.888171412160391 0.202622903640567 no 723 0.187224276976194 935 5393163
SGTC_1444 4112-3581 28 µM 0.88813743779029 0.202632146226267 no 724 0.18723341330594 954 2877249
SGTC_826 1683-5028 118 µM 0.887924331215411 0.20269012672831 no 725 0.187290727851034 907 722377
SGTC_252 miconazole 1.30953 nM 0.88567478951147 0.203302770308053 no 726 0.187896398575206 909 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1772 st048439 82.2 µM 0.885041162087027 0.203475532618388 no 727 0.188067215644489 897 2927068 YDL195W SEC31
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.880956331092433 0.204591386769038 no 728 0.189170728146038 1004 5024745
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.88092300757085 0.204600504709537 no 729 0.189179746822754 981 23665772 A membrane-active detergent.
SGTC_2006 4011487 200 µM 0.880821603541013 0.204628252241224 no 730 0.189207192434447 962 45595294
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.879882248764837 0.204885397516623 no 731 0.189461550996411 922 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.879588438319373 0.204965866588748 no 732 0.189541152194549 930 6312947
SGTC_48 0382-0018 55 µM 0.879105639120066 0.205098136869051 no 733 0.189672000239553 920 762596
SGTC_2698 st077697 67.5 µM 0.877649892842655 0.205497267960904 no 734 0.190066872235027 879 3154499
SGTC_2312 7706453 155.7 µM 0.874927511273579 0.206244916928542 no 735 0.190806674398281 912 976098
SGTC_2960 9079389 5.97 µM 0.874830048777014 0.206271712961816 no 736 0.190833192369974 948 16457355
SGTC_684 1140-0066 328 µM 0.87300860776735 0.206772873772955 no 737 0.191329192985803 966 6813534
SGTC_3285 9112818 20.8695 µM 0.870348191973842 0.207506168473785 no 738 0.192055074996905 987 17017947 YPR165W RHO1
SGTC_1218 1348-1416 30.7 µM 0.869920393456249 0.207624226550233 no 739 0.19217195490168 959 6787668
SGTC_69 0096-0274 206.684 µM 0.869733941559624 0.207675693450405 no 740 0.192222909504455 1013 6741392
SGTC_1788 fluconazole 20 µM 0.869516328756035 0.207735771324206 no 741 0.192282390382395 878 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_885 0865-0106 16.8 µM 0.868680118335639 0.207966725229008 no 742 0.192511059459215 972 2793380
SGTC_2925 9010536 32.5 µM 0.866293071094688 0.208626839982383 no 743 0.193164732526344 990 2994177
SGTC_2469 5655019 90.81 µM 0.865734338415811 0.208781530286877 no 744 0.193317932294017 1019 2788239
SGTC_3060 1327-0027 12.5 µM 0.865714138031763 0.208787124215524 no 745 0.193323472456641 921 16000455 YPR107C YTH1
SGTC_1682 st012968 530 nM 0.864601953518026 0.209095248732184 no 746 0.19362864997125 855 24207270
SGTC_1554 st069299 38.7 µM 0.864462743858552 0.209133834838227 no 747 0.193666869037741 960 24207999
SGTC_473 2-arachidonoylglycerol 10 µM 0.863900276717132 0.209289782056229 no 748 0.193821337406004 904 5282280 An endocannabinoid.
SGTC_685 1278-0033 54.9 µM 0.861964214105531 0.209827089439605 no 749 0.194353605343703 967 3590572
SGTC_1632 st005650 90 µM 0.859306762441878 0.210565919774342 no 750 0.195085647124594 922 2759605
SGTC_2792 7535235 81.82 µM 0.859101806971003 0.210622965269338 no 751 0.195142175244128 882 1281891
SGTC_1667 st014849 34.6 µM 0.857936472774491 0.210947486404812 no 752 0.195463771560757 974 5348460
SGTC_2319 6033012 152.6 µM 0.855966665844342 0.211496702403354 no 753 0.196008108941445 881 847246
SGTC_3090 9117696 49.47 µM 0.85507818924277 0.211744698681908 no 754 0.196253931620325 937 7923821
SGTC_54 0159-0055 9 µM 0.851410586557307 0.212770218831593 no 755 0.197270656491884 970 3319099
SGTC_197 4544-0043 41.561 µM 0.851091213006162 0.212859657796603 no 756 0.197359343095074 1017 896523
SGTC_1732 st034308 51.822 µM 0.85086415759817 0.212923256871173 no 757 0.197422408605334 914 830119
SGTC_1783 st039459 87.517 µM 0.843832558039359 0.214898317514732 no 758 0.199381489592698 1037 729761
SGTC_1333 1482-0047 286 µM 0.843210097968764 0.215073667527535 no 759 0.199555475939485 1012 3811116
SGTC_1265 0819-1001 68.8 µM 0.842584134793352 0.215250088128345 no 760 0.199730533569103 952 3106768
SGTC_751 0833-0568 350 µM 0.842113833330156 0.215382692483482 no 761 0.199862119414955 972 6954252
SGTC_167 3672-0051 66.205 µM 0.841978333116797 0.215420906384776 no 762 0.199900040749799 937 3237971
SGTC_2178 5812956 200 µM 0.840838586058894 0.215742494600989 no 763 0.200219183658075 1011 5403383
SGTC_2070 5230947 200 µM 0.839498668254017 0.21612091816119 no 764 0.200594768103993 1069 2835538
SGTC_658 3253-0951 102 µM 0.838581341277829 0.216380213898271 no 765 0.200852142385044 1041 1184878
SGTC_1522 st012842 45.6 µM 0.838266099890858 0.216469362989586 no 766 0.200940635340648 876 3491067 YOR116C RPO31
SGTC_1645 Cervolide 78 µM 0.837201168689174 0.21677067869993 no 767 0.201239750338723 937 23173 A fragrance.
SGTC_628 1636-0253 16 µM 0.835981664095915 0.217116027701131 no 768 0.201582609184242 992 4456143
SGTC_2982 9019404 25.97 µM 0.83440707152314 0.21756240319394 no 769 0.202025816859624 929 22333232
SGTC_3223 9129970 49.47 µM 0.833812527404439 0.217731085987355 no 770 0.202193317438687 1028 17248386
SGTC_1838 st055369 84.5 µM 0.833293494548916 0.217878406551799 no 771 0.202339612176501 1016 676036
SGTC_2868 9035608 32.47 µM 0.833095510955372 0.217934616700919 no 772 0.202395432559698 1012 6462614
SGTC_1562 morin hydrate 59.1 µM 0.831576232415846 0.21836623808224 no 773 0.202824091157041 972 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.831504411227139 0.218386654396404 no 774 0.202844368646014 948 4620898
SGTC_1283 0922-0125 16.4 µM 0.831502724933148 0.218387133765478 no 775 0.202844844756943 1038 3360884
SGTC_600 1495-0418 41.6 µM 0.830832849116017 0.218577609795798 no 776 0.203034031363371 965 5377768
SGTC_1104 tacrolimus 29.8 µM 0.82946109258894 0.218967960628234 no 777 0.203421772048912 1024 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1411 3909-8223 150 µM 0.827146629964424 0.219627478679217 no 778 0.204076978622452 1063 X1411
SGTC_178 4092-0806 87.505 µM 0.825708013748444 0.220037994026128 no 779 0.204484872627755 996 2169044
SGTC_3026 9090633 49.47 µM 0.825208025967861 0.220180770713055 no 780 0.204626748800109 1035 25236842
SGTC_2400 5203494 178.7 µM 0.823413440301358 0.220693670597293 no 781 0.20513646126848 944 6777674
SGTC_2098 5376439 882.5 nM 0.822311270880496 0.221009014017238 no 782 0.205449881831248 1055 2844116
SGTC_2368 9071271 200 µM 0.821840577659982 0.221143763335741 no 783 0.205583818035175 984 27209959
SGTC_2753 fluvastatin 17.09 µM 0.821770963181871 0.221163696448925 no 784 0.205603631300298 983 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1014 4130-3005 69.3 µM 0.820891808144603 0.221415518404676 no 785 0.205853948796033 1009 743608
SGTC_963 1269-2853 151 µM 0.819530637434661 0.221805730393827 no 786 0.206241864726119 990 3668223
SGTC_563 tetrahydrosecaminediol 614 µM 0.819064963244813 0.221939317115288 no 787 0.206374675219081 1058 334274 A psychoactive constituent of the cannabis plant.
SGTC_1613 st002381 52.1 µM 0.818992370573157 0.221960145721084 no 788 0.206395383247335 1057 551167
SGTC_1986 st071812 45 µM 0.81822841103036 0.222179411994189 no 789 0.206613387551424 975 11838594
SGTC_2470 5664817 21.68 µM 0.817814987231434 0.222298121503103 no 790 0.206731419451631 1015 2859561
SGTC_2969 9091408 28.7 µM 0.817299056094767 0.222446315465318 no 791 0.206878773034136 942 4286311
SGTC_1802 st050112 57.9 µM 0.816186746171907 0.222766002449558 no 792 0.207196668024716 1057 4662563
SGTC_990 3985-0011 41.3 µM 0.815444602022171 0.222979446298491 no 793 0.20740893129565 949 5399565 YGL099W LSG1
SGTC_289 k017-0060 526 µM 0.814821331948664 0.22315879140792 no 794 0.207587294244741 1037 5512909
SGTC_2401 5128683 200 µM 0.814720029341417 0.223187948851059 no 795 0.207616292857253 990 708373
SGTC_2113 5491891 107.031 µM 0.812813731065195 0.223737033775434 no 796 0.208162430869375 1048 789979
SGTC_1659 st012954 42.1 µM 0.810631583463433 0.224366515236834 no 797 0.208788636857969 984 24207262
SGTC_1065 prochlorperazine maleate 2.48 µM 0.810596238520053 0.224376719416023 no 798 0.208798788843936 1067 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1922 5578187 25 µM 0.806772677203283 0.225482146219137 no 799 0.209898731722643 1013 1350412
SGTC_2974 9094440 9.66 µM 0.805291339092441 0.225911241818126 no 800 0.210325789247553 1037 25236134
SGTC_3132 9126706 49.47 µM 0.804635470209885 0.226101373130526 no 801 0.210515033649918 981 850858
SGTC_198 3454-2873 16.191 µM 0.80440888711017 0.226167078829929 no 802 0.210580435154357 1036 710957
SGTC_1046 2001-0062 216 µM 0.804147883739578 0.226242779262566 no 803 0.210655786586132 982 739778
SGTC_3165 9101544 49.47 µM 0.802746493596469 0.226649477857258 no 804 0.211060637031255 1034 5002184
SGTC_1202 1988-0068 29.6 µM 0.802137117398177 0.226826454069612 no 805 0.211236823134972 1015 2850480
SGTC_828 2074-0507 139 µM 0.801996748774297 0.226867231240796 no 806 0.211277419469254 1066 X828
SGTC_2459 5811157 9.22 µM 0.794802487806927 0.228962697721352 no 807 0.213364201810453 1067 2870684 YBR192W RIM2
SGTC_2439 5492030 7.2 µM 0.794569109786061 0.229030854923861 no 808 0.213432096529262 1018 5722370
SGTC_422 cantharidin 155 µM 0.792129301201805 0.229744073280319 no 809 0.214142643290615 1031 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_886 0866-0150 153 µM 0.792023553930181 0.229775014005399 no 810 0.214173471216088 1100 271463
SGTC_1921 5740136 50 µM 0.791845903442007 0.229826998233775 no 811 0.214225266506657 1075 1774243
SGTC_3351 9150312 21.596 µM 0.789723917586203 0.230448444266466 no 812 0.214844510063044 1042 4904905
SGTC_2140 5586273 200 µM 0.789645395148513 0.230471458402721 no 813 0.214867444623265 1071 854421
SGTC_2806 7952793 58.44 µM 0.788958472183054 0.230672843380394 no 814 0.215068139322141 1046 2972490
SGTC_183 3914-0051 30.55 µM 0.788886655388575 0.230693903561149 no 815 0.215089127942769 1059 1596232
SGTC_839 0122-0028 230 µM 0.78716974856278 0.231197703918188 no 816 0.215591251786746 1073 759448
SGTC_1615 st002656 86.5 µM 0.786610066535091 0.231362066721422 no 817 0.215755082296005 1060 1584458
SGTC_2993 9054257 71.4286 µM 0.785833186760698 0.231590322337615 no 818 0.215982610645086 1114 6470217 YGL055W OLE1
SGTC_748 act1.228 77.9 µM 0.785629677092281 0.23165013640244 no 819 0.216042236425569 1039 4421505 YNR035C ARC35
SGTC_2093 5331342 194.4 µM 0.785443739144004 0.231704793442076 no 820 0.21609672224713 1071 33839
SGTC_3332 9141069 11.198 µM 0.785018221256819 0.2318299027871 no 821 0.216221442668458 1031 17332883
SGTC_1024 4507-0395 26 µM 0.783552009470432 0.232261281554948 no 822 0.216651512329813 1031 4201836
SGTC_957 1187-1561 14.1 µM 0.782951582500983 0.232438063872729 no 823 0.216827772437904 1081 1538454
SGTC_1299 1079-1439 3.74 µM 0.782911883193621 0.232449755084553 no 824 0.216839429406435 1064 323161
SGTC_2351 9026858 72.31 µM 0.781915660065451 0.232743243971354 no 825 0.217132070538327 1027 1409300
SGTC_1156 4092-0367 4.88 µM 0.779536636437378 0.233444940402659 no 826 0.217831832454629 1076 1357585
SGTC_2687 chenodiol 100 µM 0.778842563191999 0.23364987921611 no 827 0.218036230794945 1035 5702181 A cholesterol synthesis inhibitor.
SGTC_1217 1183-1422 255 µM 0.775911860337827 0.234516325913973 no 828 0.218900514619686 1119 2849664
SGTC_1298 1079-1278 263 µM 0.775314552445409 0.234693134604915 no 829 0.219076906171647 1107 2840950
SGTC_1242 0402-0103 60.1 µM 0.772033402135911 0.235665698940383 no 830 0.220047322243094 1046 432868
SGTC_3035 9091303 49.47 µM 0.771313687654594 0.235879326073918 no 831 0.220260510584669 1089 25237002
SGTC_2780 5215298 71.43 µM 0.768657476998318 0.236668671190027 no 832 0.221048337385204 1106 2834131
SGTC_3278 9139605 49.47 µM 0.766443410824157 0.237327733213542 no 833 0.221706255542568 1093 7958859
SGTC_3152 9099253 49.47 µM 0.766273832536989 0.237378253173928 no 834 0.221756692459673 1123 25236131
SGTC_1371 2421-0008 32.7 µM 0.76449629384768 0.237908164266368 no 835 0.222285772217993 1042 2827552
SGTC_678 1218-2179 85.9 µM 0.764080365840669 0.238032252254054 no 836 0.222409676001314 1071 6820081 YOR116C RPO31
SGTC_2926 9010726 65.15 µM 0.763950772079235 0.238070922512439 no 837 0.222448289665851 1097 2994293
SGTC_2569 tetrandrine 100 µM 0.761077796657832 0.238929090509361 no 838 0.223305300713702 1006 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1718 roemerine 11.9335 µM 0.760874206413974 0.238989967757599 no 839 0.223366103073091 1062 235224 An aporphine alkaloid with mutagenic activity.
SGTC_790 1575-0012 79.1 µM 0.759757986194251 0.239323888908718 no 840 0.223699630337617 1137 378741 YLR208W SEC13
SGTC_3275 9138069 49.47 µM 0.759081386570949 0.239526420030887 no 841 0.223901936464186 1087 17617007
SGTC_1683 st010134 710 nM 0.758040436023228 0.239838197413423 no 842 0.224213387981184 1148 3818134
SGTC_3058 9093861 49.47 µM 0.755770475530245 0.240518845337437 no 843 0.224893410658738 1097 17217477
SGTC_151 3013-0144 2.285 µM 0.754983697564437 0.240755006035748 no 844 0.225129381977173 1074 906558 YHR107C CDC12
SGTC_2357 9067248 200 µM 0.753772451327249 0.241118822430678 no 845 0.225492934346946 1083 9150235
SGTC_2640 pentamidine 10.38 µM 0.752552345483588 0.241485601913492 no 846 0.225859481632346 1132 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3147 9097027 49.47 µM 0.751412676557837 0.241828474556952 no 847 0.226202168010004 1114 25236841
SGTC_424 splitomicin 100 mM 0.751100275044519 0.24192250755154 no 848 0.226296155113962 1043 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2381 9035592 200 µM 0.750503089157526 0.242102315955885 no 849 0.22647588198418 1041 4749657
SGTC_261 5-fluorouridine 15.376 µM 0.75041311474737 0.242129412887937 no 850 0.226502967336679 1104 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_323 4013-0906 34.3 µM 0.750328513161428 0.242154893225893 no 851 0.226528436954918 1137 2910086
SGTC_1966 st070145 16.1 µM 0.749825917753283 0.242306295069028 no 852 0.226679778479709 1098 3748532
SGTC_1612 st002233 45.4 µM 0.748894705486289 0.242586948980067 no 853 0.226960335858453 1159 1035021
SGTC_1301 naphtanilide LB 4.81 µM 0.748044951456696 0.242843206085011 no 854 0.22721652214 1168 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3074 9116018 49.47 µM 0.747563828827514 0.242988361337934 no 855 0.227361644600844 1145 17027303
SGTC_1447 4239-0816 81.9 µM 0.747446109492133 0.243023884542666 no 856 0.227397160586833 1086 1341554
SGTC_1256 0570-0116 285 µM 0.746333713239509 0.243359701936567 no 857 0.227732925391172 1115 410638
SGTC_1977 st070720 65.3 µM 0.745168933887756 0.243711601661008 no 858 0.228084800347165 1082 682188
SGTC_1081 sertraline 6 µM 0.744409721203436 0.243941120576477 no 859 0.228314319811891 1125 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_398 bronopol 33.3 µM 0.744109152962555 0.244032018101665 no 860 0.228405221196164 1085 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2541 muurolladie-3-one 83.07 µM 0.742905350884212 0.244396253682172 no 861 0.228769492943807 1116 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_896 0964-0007 44.5 µM 0.742439807814369 0.244537192022075 no 862 0.228910454161251 1133 6756758
SGTC_423 5-fluorouracil 457 µM 0.742256307937089 0.244592756735354 no 863 0.228966029254923 1106 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_793 0488-0545 106 µM 0.737691844361461 0.245977085679752 no 864 0.230350864611443 1103 292548
SGTC_1475 4092-1048 11.7 µM 0.737397876082699 0.246066385433212 no 865 0.230440213349765 1153 2881759
SGTC_2759 disulfiram 3.38 µM 0.736802831893439 0.246247197265367 no 866 0.230621130404407 1117 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1358 1509-0022 2.48 µM 0.735749568346505 0.246567419505616 no 867 0.230941558816115 1151 3258434
SGTC_2790 5423970 71.43 µM 0.73571800250079 0.246577019867136 no 868 0.23095116574954 1146 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2296 7971656 126.45 µM 0.735167328166224 0.24674453286599 no 869 0.231118797077917 1147 666570
SGTC_480 am 92016 50 µM 0.734703682998425 0.246885619164361 no 870 0.231259988404837 1074 2129 K+ channel blocker.
SGTC_2375 9072683 200 µM 0.734518800880215 0.246941890462737 no 871 0.231316302961154 1207 16798029
SGTC_68 0986-0284 82.829 µM 0.734398484747174 0.246978513942738 no 872 0.231352955013974 1035 423278 YIL048W NEO1
SGTC_2085 5307070 144.047 µM 0.733788006234359 0.247164384569013 no 873 0.231538975742276 1109 2840351
SGTC_1140 3229-1848 2.98 µM 0.733438110101452 0.247270950149314 no 874 0.231645631214338 1147 2849525
SGTC_3140 9094243 49.47 µM 0.732889170720025 0.247438186521387 no 875 0.23181301428439 1197 19291112
SGTC_1159 4092-0538 61.2 µM 0.731234506036446 0.247942651601247 no 876 0.232317963471901 1189 717301
SGTC_619 1652-1634 108 µM 0.729982272518442 0.248324790234183 no 877 0.232700510340229 1098 5400454
SGTC_3011 9081274 71.4286 µM 0.72929237699808 0.248535456701527 no 878 0.232911417136287 1159 6625322
SGTC_2143 5623677 140.463 µM 0.728114899155321 0.2488952311193 no 879 0.233271627048915 1123 5375313
SGTC_792 4534-1957 155 µM 0.726331918764084 0.249440542056349 no 880 0.233817658229437 1108 1717904
SGTC_263 alizarin 107.927 µM 0.724505880818709 0.249999679274407 no 881 0.234377609046067 1168 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.724334983291388 0.250052042521911 no 882 0.234430052373363 1167 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1174 0739-0097 51.1 µM 0.722939168048829 0.250479940074721 no 883 0.234858629213847 1145 728447
SGTC_1516 st013856 110 µM 0.721665955290828 0.250870591061194 no 884 0.235249939045678 1102 5281404 A mutagen and neurotoxin.
SGTC_96 0929-0093 37.281 µM 0.720702721757467 0.251166347434509 no 885 0.235546218737108 1108 6991579
SGTC_1162 k048-0130 20.1 µM 0.720372456889961 0.251267796163657 no 886 0.235647851831786 1131 6797406
SGTC_2352 9027995 87.8 µM 0.719752689932722 0.251458230825823 no 887 0.235838639273213 1111 2997347
SGTC_814 3342-0569 96 µM 0.719240779229513 0.2516155821931 no 888 0.23599628872176 1186 4346283
SGTC_3291 9121177 71.43 µM 0.719072952874772 0.251667180060488 no 889 0.236047985631632 1091 17015612
SGTC_2893 9048488 25.97 µM 0.718484450809888 0.251848157957148 no 890 0.236229315977694 1135 6467338
SGTC_651 3253-0966 34.4 µM 0.717404929519447 0.252180314053655 no 891 0.236562139413468 1190 781462
SGTC_440 fluspirilene 35.1 µM 0.717375309819719 0.252189430944871 no 892 0.236571274994987 1179 3396 An atypical antipsychotic.
SGTC_1962 st076595 64.5 µM 0.716276389462874 0.252527799508667 no 893 0.236910351335745 1186 279619
SGTC_2626 ethyl orsellinate 100 µM 0.715909776462763 0.252640736504946 no 894 0.237023530672138 1168 75653 A natural product.
SGTC_513 4245-1575 41.7 µM 0.715861184121141 0.252655707619024 no 895 0.237038534140447 1178 719745
SGTC_2218 6965428 192.983 µM 0.71470628608273 0.253011664755605 no 896 0.237395276332372 1157 675684
SGTC_140 0062-0056 502.533 µM 0.713645898737266 0.25333872447147 no 897 0.237723084059578 1169 3758964
SGTC_1058 3448-5425 97.3 µM 0.711916094068442 0.25387273198469 no 898 0.238258367715282 1113 7279705
SGTC_917 harmaline 728.087 nM 0.711110354405992 0.254121673193305 no 899 0.238507927027234 1138 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_573 3702-0553 84.7 µM 0.710500026510595 0.254310325198881 no 900 0.238697057251658 1153 1222756
SGTC_547 1120-0019 610 nM 0.710373108651255 0.254349564656053 no 901 0.238736397239682 1126 3676939
SGTC_2988 9073640 71.4286 µM 0.710199491943792 0.25440324723228 no 902 0.238790217941792 1185 9102229
SGTC_2304 7443016 91.4 µM 0.709637729205012 0.254576985892289 no 903 0.238964408320434 1105 939854
SGTC_2834 9001755 58.44 µM 0.70948704318237 0.254623599744457 no 904 0.239011144586012 1079 2989575
SGTC_482 fipronil 114 µM 0.708144358228109 0.255039148892861 no 905 0.239427807762876 1201 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1982 st072467 71.9 µM 0.706886585614258 0.255428740015519 no 906 0.239818480426212 1145 3163533
SGTC_1364 1653-0028 37.6 µM 0.70661565076133 0.255512701927794 no 907 0.239902680120513 1148 5718652
SGTC_288 1315-0019 35.1 µM 0.706206306734987 0.255639583778396 no 908 0.240029924459936 1202 6811474
SGTC_1693 xanthone 101.9 µM 0.705439407969662 0.25587738321248 no 909 0.240268413488236 1194 7020 An insecticide.
SGTC_3066 9117245 49.47 µM 0.705416935612795 0.255884353165776 no 910 0.240275403854716 1217 17176980
SGTC_584 0986-0246 15.4 µM 0.705304462569405 0.25591923892887 no 911 0.240310391961139 1280 53315 YDR232W HEM1
SGTC_3073 9114972 49.47 µM 0.70280339564058 0.256695635583718 no 912 0.241089140395115 1102 41905075
SGTC_3302 9125395 16.351 µM 0.701587890401679 0.25707340257868 no 913 0.241468102866041 1159 17599668
SGTC_1122 capsaicin 818.572 nM 0.699463516071482 0.257734330688519 no 914 0.242131202890819 1200 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3135 9127742 49.47 µM 0.699086160046837 0.257851824599529 no 915 0.242249093590164 1154 3643468
SGTC_1243 0416-0003 5.65 µM 0.69812373174931 0.258151612934103 no 916 0.242549908927461 1181 2141977
SGTC_964 1287-0107 19.4 µM 0.695614269146383 0.258934138504689 no 917 0.243335213817019 1190 51516812 YPR165W RHO1
SGTC_2034 5197015 53.07 µM 0.695384444354882 0.259005866040158 no 918 0.243407203227431 1185 780676
SGTC_1829 berberine 14.4 µM 0.692970757057792 0.259759789834638 no 919 0.24416395169765 1198 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_103 0844-0104 51.839 µM 0.692872958631594 0.259790361375605 no 920 0.244194640553924 1253 5375804
SGTC_855 0428-0020 25 µM 0.691569417972058 0.260198022111118 no 921 0.244603886278256 1193 6812414
SGTC_2575 plumbagin 510 nM 0.691416564930315 0.260245845953631 no 922 0.244651898573835 1175 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_668 1682-0499 62.6 µM 0.690449063121726 0.2605486577839 no 923 0.244955915890929 1227 682214
SGTC_1457 k015-0032 57.3 µM 0.689928570799653 0.26071163815989 no 924 0.245119553829598 1184 4302660
SGTC_2294 7971431 200 µM 0.689126909869226 0.26096276270391 no 925 0.245371703524581 1138 5741572
SGTC_1539 benzyladenosine 56 µM 0.688804287116439 0.261063861085288 no 926 0.245473218706127 1187 92208 A nucleotide analog.
SGTC_2404 5161160 200 µM 0.688315832456701 0.261216963538134 no 927 0.245626956826141 1186 2831543
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.6881042711994 0.261283290145013 no 928 0.245693560485228 1242 1377
SGTC_1737 st035557 69.7 µM 0.687635773431902 0.261430199750489 no 929 0.245841087338402 1106 5716916
SGTC_2730 imipramine 71.33 µM 0.686354938350305 0.261832055146809 no 930 0.246244656417531 1233 3696 A tricyclic antidepressant.
SGTC_1076 itraconazole 331 nM 0.686025726975188 0.261935394675531 no 931 0.246348442605719 1228 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_754 3474-0146 171 µM 0.685563889825961 0.262080400705776 no 932 0.246494079506134 1168 24762078
SGTC_1668 st014914 51.6 µM 0.684962728830783 0.262269212769339 no 933 0.246683720226143 1221 2839556
SGTC_464 bw-b 70c 158 µM 0.683474948345892 0.262736792850371 no 934 0.24715338744039 1233 5353454
SGTC_1466 k213-0079 57.5 µM 0.683462017534673 0.262740858617872 no 935 0.247157471574809 1177 3657981
SGTC_3051 9093778 49.47 µM 0.68338355007117 0.262765531423188 no 936 0.247182255919147 1225 17217378
SGTC_2423 st077119 87.2 µM 0.682310345601675 0.263103101849864 no 937 0.24752136632905 1186 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2355 9061122 103.12 µM 0.680947433733918 0.26353211728028 no 938 0.247952376299384 1195 5302957
SGTC_3025 9087895 49.47 µM 0.678384357808368 0.264339884467055 no 939 0.248764012169859 1234 17173641
SGTC_334 1502-1024 68.5 µM 0.678178032603771 0.264404963742443 no 940 0.248829409560751 1251 3296216
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.6748871988015 0.265444062584171 no 941 0.249873717075082 1255 364106
SGTC_104 0074-0074 590.992 µM 0.673929697863848 0.265746787446552 no 942 0.250178005119917 1099 3943124
SGTC_409 arachidonic acid 100 µM 0.673783640601276 0.265792980499292 no 943 0.250224438510042 1257 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1347 1493-0251 600 nM 0.672525343398316 0.266191106534174 no 944 0.250624655792349 1252 3986378
SGTC_1745 st081495 74 µM 0.671895091233563 0.266390632139785 no 945 0.250825242812921 1187 13842402 YBL026W LSM2
SGTC_2237 6667747 47.222 µM 0.671054287278403 0.26665693211679 no 946 0.251092973304224 1184 729940 YDL015C TSC13
SGTC_1452 4194-0072 190 µM 0.669395532573885 0.267182688347096 no 947 0.251621600320794 1273 1343545
SGTC_269 exalamide 29 µM 0.66679404645702 0.268008303657652 no 948 0.252451848054758 1224 3316 A derivative of salicylamide.
SGTC_2923 7992654 58.14 µM 0.665303780353531 0.268481836895287 no 949 0.252928106573653 1267 2985126
SGTC_948 3448-0295 75.3 µM 0.665080980786117 0.268552667761933 no 950 0.252999349360766 1265 678569
SGTC_2107 5363541 170.161 µM 0.663896741992219 0.268929310179074 no 951 0.253378200816111 1227 244052
SGTC_364 0083-0097 67.7 µM 0.661298201665114 0.269756693911933 no 952 0.25421054726398 1291 5207356
SGTC_2379 9035213 200 µM 0.660749477608651 0.269931572319525 no 953 0.254386493925085 1271 646551
SGTC_1176 0848-0131 83.3 µM 0.659419939624267 0.270355531371608 no 954 0.254813070671166 1303 6769040
SGTC_1279 0874-0590 65.2 µM 0.658482296789698 0.270654724094227 no 955 0.255114134488829 1271 3523074
SGTC_712 r015-0009 80.6 µM 0.658451254327852 0.270664632269429 no 956 0.255124104963809 1223 6813872 YLR060W FRS1
SGTC_3213 9129884 49.47 µM 0.657204295546713 0.27106278798535 no 957 0.255524781969248 1191 17190742
SGTC_3354 9151612 71.43 µM 0.65702808269626 0.271119076548508 no 958 0.25558142977566 1247 27261949
SGTC_148 3253-0744 288.01 µM 0.653515482016982 0.2722423390998 no 959 0.256712005865073 1234 6893655
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.65226376712245 0.272643171748965 no 960 0.257115514869841 1331 688664
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.650460920814948 0.273221005721581 no 961 0.257697268425504 1247 688667
SGTC_2833 9001315 45.46 µM 0.649314647463068 0.273588715396832 no 962 0.258067510025298 1285 2989378
SGTC_753 1322-0200 289 µM 0.64784438077312 0.2740607161631 no 963 0.258542803667242 1289 5403907
SGTC_1284 0929-0043 16 µM 0.647715712522462 0.27410204176247 no 964 0.258584419860957 1254 1239883
SGTC_1805 st050013 60.3 µM 0.647696787291291 0.274108120417719 no 965 0.258590541291316 1229 4037144
SGTC_1268 0828-0275 2.46 µM 0.646757977001071 0.274409743450943 no 966 0.258894296829839 1309 745337
SGTC_1638 st008370 60.6 µM 0.643821697320339 0.275354173954712 no 967 0.259845531139383 1273 24207134
SGTC_1342 1486-1464 234 µM 0.64251891518858 0.275773714921698 no 968 0.260268155928463 1295 3253938
SGTC_2119 5528445 120.635 µM 0.642351476176919 0.275827658856113 no 969 0.260322499110014 1317 791935
SGTC_2785 7756463 72.73 µM 0.640789887897195 0.276331006277423 no 970 0.260829601860794 1263 2201551
SGTC_1462 k081-0014 26.5 µM 0.640199395608812 0.276521457252534 no 971 0.261021487840754 1094 3270634
SGTC_2968 9090663 33.37 µM 0.64006696075951 0.276564180185186 no 972 0.261064533743179 1261 25236811
SGTC_1684 st024538 14.6195 µM 0.639903523832443 0.27661690871961 no 973 0.26111766142247 1268 6732859
SGTC_1455 4262-0120 131 µM 0.639893065600983 0.276620282954796 no 974 0.26112106122014 1357 1529587
SGTC_2110 5483698 200 µM 0.639145433299536 0.276861550678868 no 975 0.261364163023464 1282 2848765 YHR062C RPP1
SGTC_762 1165-0429 115 µM 0.637835928153995 0.277284388044283 no 976 0.261790244608933 1307 5967793
SGTC_626 0214-0009 33 µM 0.636883265774249 0.277592199717286 no 977 0.2621004418592 1347 3437874
SGTC_536 3852-0578 10.6 µM 0.635824904232672 0.277934359152772 no 978 0.262445276656533 1318 2869208
SGTC_2845 9003024 42.97 µM 0.635793862783125 0.277944397700067 no 979 0.262455394070296 1357 2990173
SGTC_3321 9137793 26.8275 µM 0.635051319078888 0.278184582904041 no 980 0.262697472617432 1284 4904192
SGTC_320 4092-0846 5.34 µM 0.634962133321902 0.278213437978471 no 981 0.262726555973299 1275 1359356
SGTC_2894 9048625 32.47 µM 0.633954932962217 0.278539407889049 no 982 0.263055116957863 1365 4092861
SGTC_3189 9110682 49.47 µM 0.633573962920351 0.278662753350699 no 983 0.263179448722894 1323 17122418
SGTC_1628 st004252 77.7 µM 0.633258842110284 0.278764799108814 no 984 0.263282312893314 1309 692968
SGTC_397 arbidol 50 µM 0.632560467440324 0.278991018994717 no 985 0.263510354905113 1354 131410 A RNA synthesis inhibitor.
SGTC_1263 0774-1208 64.8 µM 0.632213555255573 0.279103425147651 no 986 0.263623670463147 1330 906585
SGTC_2474 5321570 43.32 µM 0.631985072035201 0.279177470086683 no 987 0.263698315905468 1332 2841384
SGTC_3005 9076496 71.4286 µM 0.629624308451494 0.279943085212836 no 988 0.264470207753101 1305 21368410
SGTC_6 0844-0013 19.835 µM 0.629241225494179 0.280067418120171 no 989 0.264595571592365 1390 1584900
SGTC_77 0828-0286 12.516 µM 0.627726927068284 0.280559158695882 no 990 0.265091421272917 1267 745345
SGTC_936 3005-4620 401 µM 0.62753652897964 0.280621016531664 no 991 0.265153799591509 1364 777207
SGTC_404 fumagillin 50 µM 0.627238965635204 0.280717704162853 no 992 0.265251302372114 1309 12015870 A methionine aminopeptidase binder.
SGTC_968 1309-0633 340 µM 0.627143233273612 0.280748814024737 no 993 0.26528267492902 1285 3761976
SGTC_716 1683-5115 658 µM 0.627032121093209 0.280784923911318 no 994 0.265319089984976 1316 723597
SGTC_704 1310-0270 142 µM 0.626132977404631 0.281077215480836 no 995 0.26561386177213 1274 5718033
SGTC_1367 1812-0510 76.9 µM 0.62404236683728 0.281757394035959 no 996 0.266299880890518 1309 1142582 YDR527W RBA50
SGTC_462 ag-879 158 µM 0.622821528657681 0.282154959399175 no 997 0.26670090464609 1306 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1149 3909-7961 23.3 µM 0.622496751253965 0.282260768461492 no 998 0.266807639664324 1278 735261
SGTC_687 k029-0044 34.9 µM 0.622469902990633 0.282269516197716 no 999 0.26681646405768 1334 5829338
SGTC_184 1494-0393 24.714 µM 0.621663965968992 0.282532168368093 no 1000 0.267081425262205 1286 3090647
SGTC_3264 9137442 49.47 µM 0.621614729639709 0.28254821813037 no 1001 0.267097616585157 1368 17015726
SGTC_3049 9092223 49.47 µM 0.621295071115524 0.282652429151565 no 1002 0.267202748057207 1285 8623917
SGTC_2827 7993847 71.43 µM 0.620094779038719 0.283043897982622 no 1003 0.267597694646344 1298 2985692
SGTC_1964 st076914 61 µM 0.620083475927099 0.283047585668435 no 1004 0.267601415243778 1308 24208661
SGTC_2630 antimycin a 100 µM 0.619793405569525 0.283142230182714 no 1005 0.267696905397078 1291 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_823 0417-1665 178 µM 0.619558633008931 0.28321884318049 no 1006 0.267774204279605 1328 3429856
SGTC_891 0929-0073 133 µM 0.618104669465983 0.283693534408543 no 1007 0.268253172232176 1359 5603632
SGTC_1177 0983-0204 23.6 µM 0.617066190106687 0.284032811124567 no 1008 0.268595534118607 1335 766818
SGTC_3257 9139206 32.98 µM 0.61681925345207 0.28411351519698 no 1009 0.268676975551649 1292 4910041
SGTC_673 1082-0474 110 µM 0.615937457940153 0.284401793917645 no 1010 0.268967899093901 1336 3098046
SGTC_2727 riluzole 51.77 µM 0.61592664497277 0.284405329786342 no 1011 0.268971467508539 1317 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3032 9089427 49.47 µM 0.61555584254772 0.284526595860696 no 1012 0.269093851331663 1284 17173707
SGTC_1478 0453-0656 35.7 µM 0.615315975885448 0.284605054261976 no 1013 0.269173034517894 1325 5258496
SGTC_1902 st060212 70.5 µM 0.615100681154707 0.284675484183837 no 1014 0.269244116134883 1328 688944
SGTC_1332 1480-0653 17.5 µM 0.613901591086806 0.285067897756058 no 1015 0.269640179367864 1272 5749438
SGTC_1042 0350-0096 82 µM 0.612585838231782 0.285498786846908 no 1016 0.270075112277782 1311 3122515
SGTC_1657 st012939 43.4 µM 0.61188624654583 0.285728018695741 no 1017 0.270306510892292 1356 24207257
SGTC_734 2023-0417 80 µM 0.609067370410619 0.286652552334058 no 1018 0.271239892233459 1328 3935732
SGTC_578 3460-0051 92 µM 0.609020444706674 0.286667955000924 no 1019 0.271255443775649 1373 2876744
SGTC_385 1494-0393 12.4 µM 0.607692483954357 0.287104001052354 no 1020 0.271695724442292 1349 3090647
SGTC_3092 9117248 49.47 µM 0.607377955236008 0.287207324940067 no 1021 0.271800057402851 1372 17141857
SGTC_3328 9140624 29.0385 µM 0.607311088520022 0.287229293180564 no 1022 0.271822240466676 1345 4904392
SGTC_1026 k007-1105 30.6 µM 0.607293846501375 0.287234957963567 no 1023 0.271827960660399 1333 7066794
SGTC_2818 7996756 12.99 µM 0.60560916999722 0.287788705206166 no 1024 0.272387155808731 1310 2241621
SGTC_2438 5259590 200 µM 0.605366589477022 0.287868482087151 no 1025 0.272467722666926 1334 1201127
SGTC_1712 st032288 53.4 µM 0.604849759651675 0.288038485508051 no 1026 0.272639413807909 1305 2883011
SGTC_1239 0337-0584 35.4 µM 0.604655513707255 0.288102392048109 no 1027 0.272703956293668 1394 914301 YML130C ERO1
SGTC_3015 9080845 49.47 µM 0.601587540000935 0.28911263573065 no 1028 0.273724362451877 1405 5296973
SGTC_2593 nobiletin 86.24 µM 0.599828564700472 0.2896925936808 no 1029 0.274310247147549 1285 72344 An anti-infammatory.
SGTC_1778 st046819 58.9 µM 0.599804945973917 0.289700384808068 no 1030 0.27431811835356 1355 671715
SGTC_1917 st066507 28.5 µM 0.59932849564088 0.289857572837663 no 1031 0.274476924589816 1351 3156428
SGTC_2053 5265679 138 µM 0.598036660844519 0.290283969452474 no 1032 0.274907735735501 1309 764595
SGTC_2047 4141938 200 µM 0.597138945851978 0.290580451634768 no 1033 0.27520730884458 1351 3807862
SGTC_2808 7946468 45.46 µM 0.59687743860379 0.290666844482733 no 1034 0.275294605667981 1371 2970879
SGTC_2125 5246583 200 µM 0.595892912184823 0.290992205287756 no 1035 0.275623384254428 1389 835267
SGTC_1066 ketoconazole 628 nM 0.595276611433504 0.291195963485852 no 1036 0.27582929358507 1402 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2486 5283202 22.39 µM 0.595176064676553 0.291229212059067 no 1037 0.275862893956869 1299 1377751
SGTC_1321 1326-2144 215 µM 0.591933005374511 0.292302568718024 no 1038 0.276947725595584 1349 3513030
SGTC_3150 9097574 49.47 µM 0.591575865988133 0.292420883664314 no 1039 0.277067319389624 1359 17217476
SGTC_2104 5389443 200 µM 0.590302255869919 0.292842992843163 no 1040 0.277494013631512 1430 2244536
SGTC_136 0097-0015 404.482 µM 0.586086109995688 0.294242352747442 no 1041 0.278908824973167 1352 4861337
SGTC_1720 st037298 9.481 µM 0.585381440166841 0.294476537137442 no 1042 0.279145632761125 1365 597396
SGTC_2754 granisetron 64.02 µM 0.585314710044767 0.294498718155956 no 1043 0.279168062814731 1407 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_853 0419-0306 21 µM 0.584937345000842 0.294624168385118 no 1044 0.279294923337126 1312 762713
SGTC_1798 st045719 60.953 µM 0.584724919760365 0.294694797308395 no 1045 0.279366347616286 1299 3980186
SGTC_340 k038-0059 454 µM 0.583632913573483 0.295057999860681 no 1046 0.279733655623451 1382 23733424
SGTC_2208 7283366 200 µM 0.583356019561536 0.295150127895378 no 1047 0.279826829125925 1397 898663
SGTC_2106 5357045 167.29 µM 0.583052191612128 0.295251232613805 no 1048 0.279929083087192 1425 668842
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.582249730572098 0.29551834391176 no 1049 0.280199240198479 1365 3256 An antibiotic and ribosome inhibitor.
SGTC_1987 st072290 61.9 µM 0.581296223061854 0.295835877700598 no 1050 0.280520412853605 1400 54697379
SGTC_1273 0849-0096 14.1 µM 0.580778326288843 0.29600841155274 no 1051 0.280694932137438 1359 5286025
SGTC_2043 5101342 149 µM 0.580473182331057 0.296110089845487 no 1052 0.28079778320429 1342 678451
SGTC_695 3505-6186 243 µM 0.580396730286501 0.296135567261125 no 1053 0.280823554795596 1390 1819379
SGTC_2981 9013952 38.96 µM 0.580200552098636 0.296200947658042 no 1054 0.280889690686425 1259 2996344
SGTC_229 benomyl 22.8748 µM 0.579664024598064 0.296379790239805 no 1055 0.281070604101901 1351 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_176 1486-1328 72.834 µM 0.57961402756205 0.296396458447236 no 1056 0.281087465628438 1343 22310231
SGTC_2624 nerol 100 µM 0.579411763824305 0.296463894308497 no 1057 0.281155684166413 1374 637566 A natural product oil.
SGTC_13 0199-0087 65 µM 0.578884759224253 0.296639633609427 no 1058 0.281333467286681 1385 4589825
SGTC_3300 9124615 50.48 µM 0.577026193576599 0.297259786748887 no 1059 0.281960880538058 1446 24824903
SGTC_2251 lansoprazole 556 µM 0.576357554596803 0.29748303833869 no 1060 0.282186763945177 1291 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_761 k216-0224 480 µM 0.57617426747975 0.297544249365058 no 1061 0.282248698244494 1446 1340404
SGTC_2777 climbazole 1.536 µM 0.575079915597737 0.297909841464986 no 1062 0.282618625262524 1385 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2675 theaflavin digallate 100 µM 0.566041359329023 0.300937166847965 no 1063 0.28568283256574 1395 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_377 3970-0964 33.1 µM 0.565821720252174 0.301010903938127 no 1064 0.285757489831551 1417 16481235
SGTC_1102 cgs 12066b 26.1 µM 0.565459635168327 0.301132480687796 no 1065 0.285880586011105 1383 6438352 A 5-HT1B full agonist.
SGTC_406 estrone 100 µM 0.563727791160666 0.301714285020388 no 1066 0.286469700398791 1480 5870 A steroid.
SGTC_709 3807-1509 243 µM 0.563395042405852 0.301826128158225 no 1067 0.286582956138356 1428 1886677 YPL242C IQG1
SGTC_3114 9122766 49.47 µM 0.562688343672028 0.302063724731246 no 1068 0.286823561463137 1338 17176985
SGTC_2062 5245942 200 µM 0.560958403540012 0.302645695634076 no 1069 0.287412947105948 1441 1376160
SGTC_2297 7971671 152.32 µM 0.56035370585501 0.302849241026735 no 1070 0.287619100905388 1465 909016
SGTC_1220 1838-0075 193 µM 0.556933998684056 0.304001489461809 no 1071 0.288786262226668 1366 5529645
SGTC_3171 9103192 49.47 µM 0.556820704965786 0.304039696482441 no 1072 0.288824968008766 1436 13018434
SGTC_758 0868-0029 16 µM 0.555400779781823 0.304518731533657 no 1073 0.289310279673248 1420 762687
SGTC_1161 k007-0610 110 µM 0.554646382273023 0.304773376437487 no 1074 0.289568278565606 1456 5843850
SGTC_994 3910-0338 138 µM 0.550130824852448 0.306299565580328 no 1075 0.291114822823326 1503 3479481
SGTC_3322 9139058 2.11 µM 0.550130317966993 0.30629973708931 no 1076 0.291114996644093 1465 4908926 YPR165W RHO1
SGTC_1572 epiandrosterone 68.9 µM 0.54987068803694 0.306387590650737 no 1077 0.291204035108377 1385 441302 A steroid.
SGTC_3265 9137266 49.47 µM 0.549866085682916 0.306389148095457 no 1078 0.291205613571651 1413 17224265
SGTC_2838 9002687 71.43 µM 0.549084580627608 0.306653661489459 no 1079 0.291473703236992 1397 6457060
SGTC_1357 1503-1303 39.5 µM 0.548204050222982 0.306951812352829 no 1080 0.291775900686551 1428 292895
SGTC_2886 9058944 51.95 µM 0.545639932030972 0.307820759239346 no 1081 0.292656734836623 1335 4949929
SGTC_1864 st057645 30.4 µM 0.545447874371776 0.30788588861735 no 1082 0.292722760798458 1432 688666
SGTC_969 1313-0238 134 µM 0.543683012741375 0.308484660472029 no 1083 0.293329812027295 1443 5212874
SGTC_3163 9099914 49.47 µM 0.541216440285261 0.309322358498388 no 1084 0.294179203544753 1451 16268368
SGTC_456 gingerol 170 µM 0.537757349789833 0.310498806427523 no 1085 0.295372290168276 1474 442793 A herb.
SGTC_2190 6049624 200 µM 0.536768511620155 0.310835470781892 no 1086 0.295713762411747 1425 2265554
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.536762596986908 0.310837484981797 no 1087 0.295715805438332 1401 688803
SGTC_3007 9078383 71.4286 µM 0.53597394195995 0.311106108404943 no 1088 0.295988279925631 1434 6496995
SGTC_816 0325-0417 81.3 µM 0.535403757159975 0.311300381487434 no 1089 0.296185346320969 1408 68101
SGTC_3078 9116413 49.47 µM 0.534473927658685 0.311617305281433 no 1090 0.296506841611748 1357 17177322
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.533788197198244 0.311851119629473 no 1091 0.296744040289468 1401 75037 A free radical scavenger.
SGTC_2642 cholecalciferol 100 µM 0.533399742381221 0.311983605201021 no 1092 0.296878447901274 1459 9821465 A vitamin D precursor, similar to steriods.
SGTC_2040 5100729 123 µM 0.53225848458901 0.312372980825516 no 1093 0.297273490757392 1465 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_47 0149-0135 24.25 µM 0.532194036098569 0.31239497569092 no 1094 0.297295806566982 1331 5239155
SGTC_2761 levamisole 97.89 µM 0.531468779447896 0.312642536051776 no 1095 0.297546985287846 1526 26879 An alkaline phosphatase inhibitor.
SGTC_1669 st015249 58.4 µM 0.531192121843726 0.312736993121835 no 1096 0.297642825859229 1485 722793
SGTC_2019 4016004 108 µM 0.530868613235801 0.312847461767453 no 1097 0.297754914563512 1392 45595336
SGTC_2361 9034121 116 µM 0.530299434312994 0.313041860375458 no 1098 0.29795216942189 1442 6496917
SGTC_2380 9035439 200 µM 0.530211065965503 0.313072046556493 no 1099 0.297982799730521 1514 6462575
SGTC_1578 josamycin 24.2 µM 0.529949040376223 0.313161560538909 no 1100 0.298073631690094 1377 5282165 A P450 substrate.
SGTC_2656 pseudo-anisatin 100 µM 0.5287242603278 0.313580119602694 no 1101 0.298498372588266 1444 6708809 A neurotoxin.
SGTC_1899 st063254 59.6 µM 0.528320347548218 0.313718206335383 no 1102 0.298638505663924 1356 3093813
SGTC_231 b-estradiol 524 µM 0.527028925524415 0.314159883268713 no 1103 0.299086750857544 1384 450 A steroid.
SGTC_452 diindolylmethane 8 µM 0.526441069089122 0.314361023227864 no 1104 0.299290893573675 1447 3071 Inhibits expression of several cancer promoting factors.
SGTC_1743 st037606 46.3785 µM 0.526328829007097 0.314399433373137 no 1105 0.299329877954557 1471 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1936 st074407 74.3 µM 0.525347907084888 0.314735204225636 no 1106 0.29967067983393 1440 809813
SGTC_2861 9024595 19.48 µM 0.524137547635296 0.315149723024717 no 1107 0.300091437316946 1425 16482810
SGTC_2290 7904846 200 µM 0.523607900016809 0.315331187785707 no 1108 0.300275642830825 1436 2962154
SGTC_622 1348-1566 26.3 µM 0.522825591242909 0.31559929933325 no 1109 0.30054781452098 1521 7340407
SGTC_2977 9011197 71.43 µM 0.522174634863104 0.315822468023641 no 1110 0.300774372503345 1505 2704722
SGTC_3106 9121286 49.47 µM 0.522128834758607 0.315838172295582 no 1111 0.300790315611135 1482 15943471
SGTC_2621 lithochol-11-enic acid 100 µM 0.52178570902854 0.315955836306919 no 1112 0.300909770488686 1520 6708711
SGTC_1685 st024049 53.0905 µM 0.521134827571348 0.31617908654754 no 1113 0.301136425385074 1433 1941139
SGTC_2654 protoveratrine a 100 µM 0.520185408193733 0.316504854520665 no 1114 0.301467177294677 1441 5702278 A heart drug and vasodilator.
SGTC_460 trequinsin 123 µM 0.52004479341897 0.316553114849432 no 1115 0.301516177557639 1476 5537 A vasodilator.
SGTC_1224 0823-0416 294 µM 0.519871082817734 0.316612738293309 no 1116 0.301576715725534 1523 3598164
SGTC_2670 beta-carotene 100 µM 0.519524877638923 0.316731582011611 no 1117 0.301697384581876 1410 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_976 1348-1067 47.6 µM 0.51701527067263 0.31759363329739 no 1118 0.302572749433478 1467 5310671 YGL099W LSG1
SGTC_304 1310-0298 97 µM 0.516340362505979 0.317825633713572 no 1119 0.302808355241146 1393 1550234
SGTC_1227 3909-8010 46.6 µM 0.516322890998639 0.317831640513462 no 1120 0.302814455515184 1476 15982272
SGTC_1469 k284-2957 126 µM 0.515164423512716 0.318230034885293 no 1121 0.303219063614883 1499 23884841
SGTC_2684 capsaicin 100 µM 0.513620139467568 0.318761437781889 no 1122 0.303758798121812 1439 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1485 3909-9022 254 µM 0.511397650094757 0.319526871931937 no 1123 0.304536320026717 1457 714516
SGTC_3021 9087658 49.47 µM 0.510122716496403 0.319966311693667 no 1124 0.304982745650707 1470 25237042
SGTC_3022 9087993 49.47 µM 0.509029514007072 0.320343314302158 no 1125 0.305365768349219 1522 17173644
SGTC_273 hydroxyurea 18.1 mM 0.508392994145319 0.320562910480501 no 1126 0.305588882495319 1491 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2649 anisomycin 9.56 µM 0.508198401859416 0.320630056391242 no 1127 0.305657105767127 1435 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1760 st045453 10.4495 µM 0.507666083889234 0.320813767733776 no 1128 0.305843768771506 1496 3323419 YIL048W NEO1
SGTC_1252 0493-0875 34.8 µM 0.504015407381657 0.322074854492399 no 1129 0.307125274989029 1454 3960963
SGTC_690 glyoxal 20.3 µM 0.502398824625681 0.322633941773002 no 1130 0.307693502834725 1381 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1816 st051957 91.6 µM 0.501035311538086 0.323105818163327 no 1131 0.308173135821905 1485 674121
SGTC_2435 5706476 10.6 µM 0.500946929095203 0.323136414863451 no 1132 0.308204236784031 1531 5725375
SGTC_373 0844-0104 25.9 µM 0.499981353845356 0.323470760704858 no 1133 0.308544103421116 1544 5375804
SGTC_1287 0971-0001 34.6 µM 0.499518341618086 0.32363113667467 no 1134 0.308707134356017 1503 4665869
SGTC_2587 piperic acid 92.2 µM 0.497184852361237 0.324439897685797 no 1135 0.309529351150598 1446 5370536
SGTC_2783 7738165 71.43 µM 0.492290260735289 0.326138996792758 no 1136 0.311257082058589 1399 17201110
SGTC_2723 salbutamol 83.58 µM 0.49215838358502 0.326184826546323 no 1137 0.311303690882803 1520 9884233 β2-adrenoceptor agonist
SGTC_1016 4226-1401 38 µM 0.491927199962204 0.326265173473484 no 1138 0.311385404503941 1482 2901613
SGTC_3053 9095903 49.47 µM 0.491670911576907 0.326354254883527 no 1139 0.311476002457451 1541 17174018
SGTC_2149 5554786 194.827 µM 0.488254495162199 0.327542686605064 no 1140 0.312684794491064 1503 745063 YPR165W RHO1
SGTC_1195 1502-0147 41.1 µM 0.488249571476141 0.32754440061965 no 1141 0.312686538042157 1463 817940
SGTC_1281 0884-0031 11.8 µM 0.487853415191388 0.327682320924944 no 1142 0.312826836658314 1472 1548255
SGTC_2515 chrysin 20.77 µM 0.487753144977947 0.327717233348372 no 1143 0.312862351622096 1564 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_143 4032-1194 15.74 µM 0.487325893643278 0.32786601204729 no 1144 0.313013700332589 1505 1806963
SGTC_455 paf C-16 10 µM 0.48590577813048 0.328360725032384 no 1145 0.313516985735762 1498 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1721 st082152 9.2685 µM 0.485754422392213 0.328413469253332 no 1146 0.313570646332816 1444 5296051
SGTC_36 0335-0881 14.2 µM 0.485270097207805 0.328582269143974 no 1147 0.313742382078285 1522 23828853
SGTC_3151 9099821 49.47 µM 0.484463336528888 0.328863523834856 no 1148 0.314028539088599 1463 17174189
SGTC_1406 3909-7906 11.9 µM 0.484183868656227 0.328960975156805 no 1149 0.314127692090267 1531 X1406
SGTC_1989 st071868 50.2 µM 0.48362717958293 0.329155129022415 no 1150 0.314325240970019 1615 16414057
SGTC_848 0368-0089 85.6 µM 0.483437798000845 0.329221189267613 no 1151 0.314392457793414 1512 762535
SGTC_2012 4023501 200 µM 0.483229318239411 0.329293917522158 no 1152 0.314466460211556 1462 3477460
SGTC_947 3447-0010 211 µM 0.482929840021098 0.32939840193156 no 1153 0.314572776681548 1478 748350
SGTC_3202 9113761 49.47 µM 0.482928591067003 0.329398837704778 no 1154 0.314573220099556 1665 4798415
SGTC_836 0330-0104 1.35 µM 0.481165885700041 0.330014094845915 no 1155 0.315199302282761 1528 46494820
SGTC_313 3474-0040 5.03 µM 0.480120931748017 0.330379044355752 no 1156 0.31557070259403 1468 1043375 YIL048W NEO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.479466463386511 0.330607699237467 no 1157 0.315803410420065 1504 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_610 4215-0184 155 µM 0.47843942227772 0.330966649179246 no 1158 0.3161687402939 1546 5605015
SGTC_2207 7258803 200 µM 0.477075482488721 0.331443585156851 no 1159 0.316654186271464 1545 3666799
SGTC_1131 3454-3128 32.3 µM 0.476645083933283 0.33159414167521 no 1160 0.316807436987707 1612 710982
SGTC_2330 7979373 200 µM 0.475696655035671 0.331926004963986 no 1161 0.317145252158156 1416 1863007
SGTC_3153 9100258 49.47 µM 0.47559953804735 0.331959994468322 no 1162 0.317179852280831 1468 25236848
SGTC_778 3456-2434 196 µM 0.475019166976908 0.332163144545343 no 1163 0.317386655899573 1664 5539063
SGTC_2581 avocatin a 64 µM 0.474533355707614 0.332333233335418 no 1164 0.317559808869615 1510 6710728 A skin care supplement.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.474421784867838 0.332372300603107 no 1165 0.3175995806135 1642 6728940
SGTC_115 0527-0192 112.043 µM 0.474237014736278 0.332437003092556 no 1166 0.317665450395712 1524 4233931
SGTC_1945 st075991 56.6 µM 0.472380518044843 0.333087384796078 no 1167 0.318327603796708 1466 1084980
SGTC_3059 1327-0034 3 µM 0.472347087102978 0.333099101181965 no 1168 0.318339532881998 1483 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2781 5567276 71.43 µM 0.471720288408963 0.333318802539219 no 1169 0.318563226867075 1573 2853274
SGTC_2874 9043904 71.43 µM 0.471099503812092 0.333536452255454 no 1170 0.318784839722725 1508 4463428
SGTC_192 3455-0609 60.9 µM 0.468846003236351 0.334327009652778 no 1171 0.319589857374643 1523 3769639
SGTC_1191 1487-1166 10.6 µM 0.468611013320992 0.334409489579299 no 1172 0.319673851835763 1608 3955771
SGTC_1331 1472-0049 76.2 µM 0.465494570187206 0.335504095462154 no 1173 0.320788662213381 1494 24051409
SGTC_1189 1431-2119 7.28 µM 0.464605401069076 0.33581666002181 no 1174 0.32110703186939 1540 3107275
SGTC_2277 7947813 106.88 µM 0.461556744496166 0.336889198308879 no 1175 0.322199609986253 1636 1246798
SGTC_1591 genipin 88.4 µM 0.461061905058077 0.337063411683308 no 1176 0.322377095972425 1585 442424 A DNA cross-linking agent.
SGTC_682 0kpi-0099 17 µM 0.459537545101846 0.337600298013356 no 1177 0.322924098472069 1516 1714895 YML126C ERG13
SGTC_2099 5377090 177.372 µM 0.458825750318119 0.33785110862348 no 1178 0.323179650801901 1507 2243829
SGTC_3174 9107204 49.47 µM 0.457439425786476 0.338339805633684 no 1179 0.323677615890604 1598 3938802
SGTC_1379 2144-0755 36.5 µM 0.457323469287637 0.338380694130555 no 1180 0.323719281567041 1611 5392327
SGTC_3028 9087778 49.47 µM 0.455334638385351 0.339082290550197 no 1181 0.324434255076578 1474 17217395
SGTC_2712 st079126 47.7 µM 0.454171018104952 0.339493037962388 no 1182 0.324852870523252 1511 3152970
SGTC_121 0557-0495 61.343 µM 0.453617558640949 0.339688471104571 no 1183 0.325052056701782 1585 3104427
SGTC_1696 st025591 34.7925 µM 0.452888414732814 0.339946006318542 no 1184 0.32531454681873 1559 2787147
SGTC_1724 st037281 8.293 µM 0.452498317735177 0.340083820111913 no 1185 0.325455016439052 1521 574124 YDL195W SEC31
SGTC_2627 acetyl isogambogic acid 100 µM 0.452267831425067 0.340165256552107 no 1186 0.325538023668889 1484 6857789 A caspase activator and apoptosis inducer.
SGTC_2298 7976326 193.81 µM 0.449447890607097 0.341162213169971 no 1187 0.326554295329173 1515 2235818
SGTC_1942 st076330 65.2 µM 0.449127372503501 0.341275598911702 no 1188 0.326669887766805 1573 24208414
SGTC_3062 9077494 49.47 µM 0.448683903784784 0.341432503008462 no 1189 0.326829848855622 1580 16459633
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.448683592322111 0.341432613217007 no 1190 0.326829961212747 1531 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.44830831887445 0.341565410508837 no 1191 0.326965348857321 1515 16623 A steroid.
SGTC_1106 tegaserod maleate 11.7 µM 0.443785080333805 0.343167579022241 no 1192 0.328598988088623 1602 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1441 4106-0040 13 µM 0.443590140142703 0.343236692113281 no 1193 0.328669467802149 1543 2904180
SGTC_316 k060-0003 58.6 µM 0.440817073528883 0.344220407714159 no 1194 0.329672716049033 1618 6152314
SGTC_1957 st077035 62.4 µM 0.440556796636576 0.344312792404272 no 1195 0.32976694288387 1595 705593
SGTC_943 3253-1379 105 µM 0.439855852820421 0.344561637002446 no 1196 0.330020756037784 1645 668464
SGTC_1101 ebselen 5.29 µM 0.439337158471046 0.344745823882082 no 1197 0.330208626689142 1698 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3127 9126946 49.47 µM 0.438330618646015 0.345103348271889 no 1198 0.330573316680511 1508 27243249
SGTC_487 nimodipine 119 µM 0.437077674265644 0.345548589133132 no 1199 0.331027508908795 1629 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1547 harmine 94.2 µM 0.436256103358935 0.345840655075964 no 1200 0.331325463383562 1571 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.434135870636848 0.346594814918986 no 1201 0.332094889303012 1652 6710655
SGTC_60 0986-0278 202 µM 0.433331127813244 0.346881218757903 no 1202 0.332387113651296 1411 3110598
SGTC_1464 k208-0027 110 µM 0.429248531223847 0.348335539017664 no 1203 0.333871184147693 1669 X1464
SGTC_2247 cerulenin 830 nM 0.427617451370748 0.348917194770552 no 1204 0.334464829162943 1656 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1800 st050079 29.0735 µM 0.425213945732692 0.349774950634146 no 1205 0.335340359435848 1579 3645560
SGTC_1203 3992-3522 103 µM 0.421037627865686 0.351267205429938 no 1206 0.336863802763102 1819 5322312
SGTC_213 1246-0773 967 nM 0.42102490621015 0.351271754568216 no 1207 0.336868447494315 1613 6251622
SGTC_3081 9117243 49.47 µM 0.420746820053692 0.351371200751965 no 1208 0.3369699841619 1713 45595589
SGTC_640 3381-0960 37.1 µM 0.420086208210744 0.351607482450065 no 1209 0.337211238776885 1676 1745025
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.418996666935476 0.351997305007121 no 1210 0.337609284131608 1616 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_959 1222-0044 107 µM 0.418899315287056 0.352032143637634 no 1211 0.337644858750156 1717 6083612
SGTC_2064 5220758 200 µM 0.418887177902095 0.352036487255386 no 1212 0.337649294142363 1613 788518
SGTC_2714 st079313 56.9 µM 0.418398739384702 0.352211301238536 no 1213 0.337827804048948 1595 2939799
SGTC_3067 9117431 49.47 µM 0.417768517013749 0.352436906340435 no 1214 0.33805818568475 1604 17150885
SGTC_2572 astragaloside iv 100 µM 0.416418672026272 0.352920294400268 no 1215 0.338551833782957 1623 45006101 An anti-inflammatory agent.
SGTC_2485 5633444 17.78 µM 0.4160574770243 0.353049680933009 no 1216 0.338683972516073 1551 5724239
SGTC_1230 0170-0365 3.77 µM 0.414683720932545 0.353541940126236 no 1217 0.339186725505401 1669 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_893 0958-0369 48.9 µM 0.41430593953419 0.353677353851783 no 1218 0.339325032276479 1740 6819948
SGTC_2038 4100038 30.985 µM 0.411970425751531 0.354514916813038 no 1219 0.340180550060199 1635 3596803
SGTC_2461 5755302 26.15 µM 0.410610527349889 0.355002928736446 no 1220 0.340679071574222 1723 2788904
SGTC_596 1155-0152 116 µM 0.410181560283597 0.355156916883782 no 1221 0.340836383268558 1594 280313
SGTC_15 0266-0086 27.098 µM 0.410124776537843 0.355177302562088 no 1222 0.340857209197089 1671 1712902 YIL048W NEO1
SGTC_2954 9074818 52.69 µM 0.410029888656067 0.355211368760651 no 1223 0.340892011228533 1664 16648742
SGTC_1842 st055362 61.2 µM 0.409593436936687 0.355368076491403 no 1224 0.341052106073612 1664 676032
SGTC_1063 disulfiram 1.84 µM 0.409296153223339 0.355474830037034 no 1225 0.341161169094698 1609 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3143 9086658 49.47 µM 0.405737228736048 0.356753705733418 no 1226 0.342467842456416 1603 25236626
SGTC_78 0336-0123 156.75 µM 0.401953875945287 0.358114995800526 no 1227 0.343858985789411 1565 6765896
SGTC_45 0kpi-0036 14.9 µM 0.401573391065719 0.358251998474337 no 1228 0.343999007976788 1647 2795021
SGTC_471 1-acyl-paf 4 µM 0.401525448468156 0.358269262647465 no 1229 0.344016652843613 1558 16759367
SGTC_1893 st059353 36.1 µM 0.399963634008342 0.358831831744559 no 1230 0.34459165099593 1580 3112488
SGTC_1073 triclabendazole 3.09 µM 0.398833357153888 0.359239151185664 no 1231 0.34500799827962 1658 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1314 1222-0010 41.1 µM 0.397725397374044 0.35963858353229 no 1232 0.345416307083123 1646 3526027
SGTC_2468 5987765 72.9 µM 0.396740232734844 0.359993875653113 no 1233 0.345779514203704 1665 26772094
SGTC_2213 7173844 200 µM 0.396391010614191 0.360119849011988 no 1234 0.345908298319949 1612 892728
SGTC_3096 9117468 49.47 µM 0.396364567113997 0.360129388478322 no 1235 0.34591805072747 1614 41316311
SGTC_1344 1488-0097 29.1 µM 0.395786849855387 0.360337821131586 no 1236 0.346131139328965 1651 747966
SGTC_2528 xanthyletin 44.79 µM 0.394763626070049 0.360707088422602 no 1237 0.346508670700688 1635 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1552 6-methylflavone 10.6 µM 0.3931828829489 0.36127781199659 no 1238 0.347092205600733 1725 689013
SGTC_2151 5563267 85.4165 µM 0.391555788619636 0.361865593183936 no 1239 0.347693230046341 1643 5310824
SGTC_813 k007-0158 173 µM 0.391461760729849 0.361899570352383 no 1240 0.347727974270408 1728 6523916
SGTC_2408 sulbentine 18.36 µM 0.39108349139281 0.362036269739212 no 1241 0.347867761405448 1704 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_776 4476-4378 112 µM 0.391042937006538 0.362050926372636 no 1242 0.347882749260233 1623 2892008
SGTC_405 ebelactone b 50 µM 0.38703261515084 0.363501280108484 no 1243 0.349366031265709 1624 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1831 st055328 12 µM 0.383838478426256 0.364657858784154 no 1244 0.35054908343131 1757 1103068
SGTC_2241 6772625 37.8075 µM 0.383526589267166 0.364770858309349 no 1245 0.350664679643053 1597 2285411
SGTC_648 0375-0473 33.3 µM 0.379969744267883 0.366060355778477 no 1246 0.351983937172738 1683 1713139
SGTC_2260 7964312 200 µM 0.379202417762103 0.366338741168094 no 1247 0.352268778150607 1762 231951
SGTC_2102 5377816 72.7585 µM 0.377976736734357 0.366783563072142 no 1248 0.352723937824348 1786 1379702
SGTC_923 1900-2434 73.3 µM 0.376259539453721 0.367407066031617 no 1249 0.353361977882924 1607 5910570
SGTC_878 0828-0289 13.7 µM 0.376068875649091 0.367476316397533 no 1250 0.353432846195463 1646 745350 YLR208W SEC13
SGTC_2864 9034755 47.6 µM 0.375638795425409 0.367632540226624 no 1251 0.353592722459347 1673 4930451
SGTC_3224 9130643 49.47 µM 0.372069764928617 0.368929810146401 no 1252 0.354920453483131 1727 17644395
SGTC_2024 5144227 134 µM 0.368627121441841 0.370182557560651 no 1253 0.356202838563055 1743 3475211
SGTC_1679 SEC14.276 6.7 µM 0.366438936776088 0.370979535947639 no 1254 0.357018784900457 1830 1005053 YMR079W SEC14
SGTC_2051 5263410 176 µM 0.365704774246682 0.371247056109349 no 1255 0.357292691611963 1717 227584
SGTC_1468 k284-1086 134 µM 0.365110046428192 0.371463813532033 no 1256 0.35751463093375 1679 15996457
SGTC_2688 kanamycin b 96.69 µM 0.364325443077215 0.371749836283876 no 1257 0.357807501346123 1681 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3013 9080133 71.4286 µM 0.362334671807394 0.372475878214914 no 1258 0.358550975775848 1737 17050193
SGTC_1003 4049-0218 100 µM 0.361315630188729 0.372847702232301 no 1259 0.358931755320344 1746 295161
SGTC_589 1227-0070 34.1 µM 0.360629633590659 0.373098072809119 no 1260 0.359188166800357 1715 2841384
SGTC_510 ag-490 170 µM 0.360331273150244 0.373206983194447 no 1261 0.359299707625888 1783 5328779
SGTC_2203 7227154 166.4 µM 0.357812111393551 0.374126954859365 no 1262 0.360241963141042 1700 896304
SGTC_2881 9058953 51.95 µM 0.357465758385343 0.374253495582635 no 1263 0.360371577966126 1626 17122249
SGTC_506 n9-isopropylolomoucine 153 µM 0.357051539419702 0.374404849050856 no 1264 0.360526611172085 1864 6610355
SGTC_236 1509-0011 5.31 µM 0.355989042472976 0.374793168393768 no 1265 0.360924385605311 1737 3107280
SGTC_1410 3909-8106 77.9 µM 0.355258561161955 0.375060216989242 no 1266 0.361197948333807 1759 1039210
SGTC_2025 5147754 141 µM 0.35156213425879 0.376412468973242 no 1267 0.362583333477215 1791 315777 YLR208W SEC13
SGTC_2840 9008771 71.43 µM 0.351024197801016 0.37660938748294 no 1268 0.362785097428666 1851 2992978
SGTC_2445 5742597 35.57 µM 0.350614784619049 0.37675927992964 no 1269 0.36293868166293 1650 1774255
SGTC_2662 daunorubicin 22.37 µM 0.350513881325834 0.376796225027951 no 1270 0.362976537165811 1696 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3173 9105693 49.47 µM 0.349114991929287 0.3773085355823 no 1271 0.363501490954831 1769 17096658
SGTC_3279 9140807 49.47 µM 0.349027966921896 0.37734041360361 no 1272 0.363534156848818 1692 45595718
SGTC_772 k072-0172 35.3 µM 0.347164855224061 0.378023087868716 no 1273 0.36423373611686 1603 5861980
SGTC_2775 cyproheptadine 69.59 µM 0.345703922241373 0.378558664020452 no 1274 0.364782618146158 1792 2913 A selective serotonin reuptake inhibitor.
SGTC_222 nsc-310342 10.666 µM 0.345396782988817 0.378671290594805 no 1275 0.364898047671828 1818 432556
SGTC_1219 1469-0211 33.1 µM 0.343449714436159 0.379385511191166 no 1276 0.365630082325977 1822 6822282
SGTC_784 4579-0127 173 µM 0.342406940859032 0.37976818924167 no 1277 0.366022332898506 1841 1948547
SGTC_1514 1189-1591 158 µM 0.342295267428686 0.379809178253047 no 1278 0.366064348379214 1786 767698 YMR146C TIF34
SGTC_2796 7949634 45.45 µM 0.341184645099426 0.380216898434743 no 1279 0.366482290985156 1674 2971588
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.340609689074313 0.380428022674818 no 1280 0.366698717177242 1799 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1119 parthenolide 318.541 nM 0.338100142144194 0.381349946305445 no 1281 0.367643861714366 1793 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_738 1315-0003 72.4 µM 0.335488078895351 0.382310246548766 no 1282 0.368628467932934 1811 6251474
SGTC_1423 4048-0112 5.59 µM 0.334552897740758 0.382654233409729 no 1283 0.368981190680051 1817 X1423
SGTC_1785 bathophenanthroline 24 µM 0.334384855396114 0.382716054099403 no 1284 0.36904458300206 1673 72812 An iron chelator.
SGTC_415 dibenzyl ketone 100 µM 0.333427979329128 0.383068133823005 no 1285 0.369405622933854 1841 7593
SGTC_2171 5739187 198.077 µM 0.332995347284682 0.383227351242405 no 1286 0.369568897630595 1663 2262761
SGTC_1307 1187-1599 12.2 µM 0.329849323479804 0.384385743902622 no 1287 0.370756908165687 1719 1538471
SGTC_1031 k035-0009 16 µM 0.329660099682487 0.384455450755585 no 1288 0.370828402828998 1856 5180959
SGTC_2383 9036125 200 µM 0.329174079446228 0.384634509525372 no 1289 0.371012056894637 1758 79580
SGTC_2411 st077133 39.94 µM 0.329105162831461 0.384659901663739 no 1290 0.371038101022209 1876 1403142 YNL221C POP1
SGTC_633 0437-0093 97.7 µM 0.328616605072081 0.384839923616181 no 1291 0.37122274775003 1715 2831118
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.326327326481491 0.385683798675051 no 1292 0.372088357653021 1815 140250 A respiratory chain inhibitor.
SGTC_1635 st007035 42.4 µM 0.324900202915925 0.386210139905574 no 1293 0.372628301654882 1714 3716403
SGTC_2561 acetosyringone 100 µM 0.3244529787802 0.386375124981108 no 1294 0.372797557916296 1720 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1740 st038286 13.222 µM 0.32332010948147 0.386793142703228 no 1295 0.373226413002724 1775 716786
SGTC_3241 9133421 49.47 µM 0.322309527606264 0.387166148439994 no 1296 0.373609107985836 1760 17018221
SGTC_457 grayanotoxin iii 135 µM 0.320878901319126 0.3876943706742 no 1297 0.374151081731947 1784 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_282 k297-0036 65.7 µM 0.318717889531283 0.388492663080072 no 1298 0.374970223851181 1789 5061378
SGTC_2817 7995342 71.43 µM 0.317956989158809 0.388773857179691 no 1299 0.375258781392249 1654 18879975
SGTC_2489 cantharidin 73.42 µM 0.317698842680698 0.388869269601593 no 1300 0.37535669458919 1685 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_131 0141-0277 33.849 µM 0.317340536549586 0.389001712714926 no 1301 0.375492610966129 1838 1547771
SGTC_2851 9015922 71.43 µM 0.317109334933794 0.389087180176706 no 1302 0.375580320952305 1835 2996893
SGTC_2612 dictamnine 15.46 µM 0.315790469137031 0.389574823019684 no 1303 0.376080776376715 1757 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1567 st069303 68.4 µM 0.315407956822159 0.389716287257992 no 1304 0.376225963131564 1747 5581319
SGTC_1154 4088-0362 150 µM 0.314884525161906 0.389909891265244 no 1305 0.376424665756052 1714 6618304
SGTC_500 h-89 112 µM 0.313023758860021 0.390598362055544 no 1306 0.377131305801836 1887 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1315 1237-0019 3.69 µM 0.311814134094694 0.391046099111759 no 1307 0.377590890886193 1842 825140
SGTC_1908 st060353 56.5 µM 0.307983552106762 0.392464921817849 no 1308 0.379047423973805 1941 4227716
SGTC_1768 st044301 37.178 µM 0.307167256181031 0.392767458069308 no 1309 0.379358033652136 1738 3931349
SGTC_2664 lyso-paf C-16 73.48 µM 0.306572815450965 0.392987810955054 no 1310 0.379584273985921 1782 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1836 st055642 81 µM 0.306121171893802 0.393155253371521 no 1311 0.379756194199941 1697 8571
SGTC_302 1094-0063 18.9 µM 0.304231133307788 0.393856180749706 no 1312 0.380475903667634 1774 5440289
SGTC_2152 5568786 200 µM 0.30327872689536 0.394209514473608 no 1313 0.380838728350835 1792 5399883
SGTC_2680 butyl paraben 22.24 µM 0.302763944708493 0.394400530043004 no 1314 0.381034881232734 1803 7184 An antifungal and steroid mimetic.
SGTC_2345 9052315 157.45 µM 0.302484815789729 0.394504114507765 no 1315 0.381141253453054 1770 6469265
SGTC_2924 9010168 62.78 µM 0.30213434351356 0.394634184984709 no 1316 0.381274826370466 1774 2993929
SGTC_2903 5923464 63.88 µM 0.298458785392723 0.39599899671834 no 1317 0.382676513960434 1904 2876576
SGTC_1827 berberine 7.24 µM 0.298274798517979 0.396067348569565 no 1318 0.382746718608204 1647 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1158 4092-0494 91.8 µM 0.295916223038961 0.396943851029427 no 1319 0.383647030715771 1873 1148199
SGTC_2908 7930301 100 µM 0.295661633191612 0.397038493864798 no 1320 0.383744250062083 1739 2223178
SGTC_1489 4065-0444 182 µM 0.294465065534284 0.397483394611018 no 1321 0.384201277155286 1921 2877968
SGTC_2000 st075254 36.4 µM 0.2937671309523 0.397742958174271 no 1322 0.384467926554756 1776 17234175
SGTC_2009 4012297 12.05 µM 0.291136835596971 0.398721577324863 no 1323 0.385473334388799 1773 45595307
SGTC_2719 novobiocin 32.65 µM 0.289108726053273 0.399476584542853 no 1324 0.386249088090232 1891 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2958 9077254 16.72 µM 0.289103508240591 0.39947852747162 no 1325 0.386251084496265 1788 16457351
SGTC_2709 st078560 56 µM 0.28815473522007 0.399831858300459 no 1326 0.386614147956267 1913 17250903
SGTC_3217 9129673 49.47 µM 0.287693559980322 0.400003633375739 no 1327 0.386790660051393 1806 17248312
SGTC_3172 9105863 49.47 µM 0.28769058974031 0.400004739771088 no 1328 0.386791796969133 1847 2348785
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.287528992624952 0.400064934869412 no 1329 0.386853652904939 1747 688664
SGTC_3012 9080433 71.4286 µM 0.286829734976307 0.400325436442199 no 1330 0.387121346955227 1949 17688859
SGTC_3161 9100388 49.47 µM 0.286789390422031 0.400340467764167 no 1331 0.387136793541528 1844 25236368
SGTC_954 1189-0853 2.85 µM 0.286344162294764 0.400506357876635 no 1332 0.387307268428759 1858 2828194
SGTC_1208 2323-2347 50.3 µM 0.285464356966312 0.400834222362365 no 1333 0.387644203916056 1929 5412760
SGTC_2776 terbinafine 19.92 µM 0.284482561143881 0.401200176663993 no 1334 0.388020298197439 1832 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1672 st016598 6.51 µM 0.284260405209525 0.401282995044297 no 1335 0.388105413550984 1772 4665860 YNL267W PIK1
SGTC_1037 k284-1091 78.7 µM 0.283512348986054 0.401561898443652 no 1336 0.388392058359418 1762 3334711
SGTC_2142 5622915 118.518 µM 0.281399065195864 0.402350080383204 no 1337 0.389202167514288 1801 5322196
SGTC_2281 7943571 200 µM 0.279351141647875 0.40311426419963 no 1338 0.389987681185372 1985 1244024
SGTC_1348 1493-0373 93.8 µM 0.27929358456242 0.403135747019963 no 1339 0.390009764630117 1842 3010129
SGTC_308 4092-1169 104 µM 0.278484364680377 0.403437814176326 no 1340 0.390320282852396 1837 2268590 YDL196W YDL196W
SGTC_1309 pyrazolanthrone 13.4 µM 0.277437005266058 0.403828860038486 no 1341 0.390722285142565 1909 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_801 0866-0028 10.1 µM 0.277034322952518 0.403979232558679 no 1342 0.390876875629528 1821 6849771
SGTC_1614 st002383 48.6 µM 0.276560869398866 0.404156051132971 no 1343 0.391058657384644 1846 1947235
SGTC_1914 st062367 72.6 µM 0.276210411132191 0.404286947823857 no 1344 0.391193230624141 1783 978205
SGTC_3006 9075424 71.4286 µM 0.275549319854026 0.404533895573496 no 1345 0.391447119968818 1768 7465181
SGTC_1257 0669-0121 16 µM 0.274913024390286 0.404771616879159 no 1346 0.391691530269503 1916 4307855
SGTC_1865 st057639 52.2 µM 0.274905647944462 0.404774372940906 no 1347 0.391694363920039 1870 688818
SGTC_2146 5545642 200 µM 0.274122956710814 0.405066836715296 no 1348 0.391995066200169 1887 825326
SGTC_1767 st044992 70.3 µM 0.273369460598207 0.405348441416208 no 1349 0.392284612962092 1767 9600693
SGTC_438 sphingosine 6.67 µM 0.273352823601749 0.405354659727608 no 1350 0.392291006752225 1664 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_910 3454-3003 490 µM 0.27019374186214 0.406535842187527 no 1351 0.393505603491317 1961 820824
SGTC_2844 9010103 25.97 µM 0.267964022158569 0.407370048579493 no 1352 0.394363506213248 1829 2480525
SGTC_2105 5350118 200 µM 0.267540905445465 0.407528397052562 no 1353 0.394526361798399 1806 2133313
SGTC_2187 6125751 200 µM 0.265678947939312 0.408225400859474 no 1354 0.395243238987869 1865 874498
SGTC_1814 st052110 31.539 µM 0.265431165765424 0.408318177404186 no 1355 0.395338665051939 1936 674163
SGTC_1958 st076513 41.9 µM 0.263489498671637 0.409045369161743 no 1356 0.396086658259235 1823 732122 YGL099W LSG1
SGTC_750 4073-0104 132 µM 0.262215653212158 0.40952261912318 no 1357 0.396577592991557 1904 22330957
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.261961321186288 0.409617921450654 no 1358 0.39667563116018 1970 6708630 An antioxidant.
SGTC_1237 0330-0133 46.1 µM 0.260914455339353 0.410010255206366 no 1359 0.397079238555335 1838 X1237 YHR072W ERG7
SGTC_2210 7115885 190.385 µM 0.259103632274988 0.410689109609842 no 1360 0.397777641164591 1875 2927039
SGTC_3167 9103034 49.47 µM 0.258859951019545 0.41078048307026 no 1361 0.39787164980727 1856 5127859
SGTC_2177 5811945 192 µM 0.258389702454551 0.410956826437119 no 1362 0.398053081543547 1926 5343475
SGTC_50 0929-0078 56.389 µM 0.257593895199809 0.411255295400996 no 1363 0.398360170839709 1912 1377751
SGTC_258 haloperidol 50.781 µM 0.257298777079676 0.411365993058286 no 1364 0.398474068216438 1803 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_877 0771-0151 33.1 µM 0.256927988070945 0.411505084572932 no 1365 0.398617182143657 1872 6166523
SGTC_970 1315-0089 19.5 µM 0.255015013795558 0.41222286172051 no 1366 0.3993557515953 1837 6811083 YLR033W RSC58
SGTC_1671 st016596 74.5 µM 0.254931966217103 0.412254029109048 no 1367 0.399387823147219 1856 2829167
SGTC_1529 apigenin 74 µM 0.254228082284381 0.412518215836471 no 1368 0.399659678308014 1974 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2592 piperlongumine 83.33 µM 0.252237117652597 0.41326569309973 no 1369 0.400428894817934 1789 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1654 st012436 41.8 µM 0.252185517508178 0.413285069778512 no 1370 0.40044883587277 1965 4323132
SGTC_1867 st057372 64 µM 0.251516654073724 0.413536257783505 no 1371 0.400707343931923 1910 688837
SGTC_2337 9009472 200 µM 0.250767444518059 0.413817661352162 no 1372 0.400996956484875 1960 5742383
SGTC_721 1187-1332 279 µM 0.250485410102178 0.413923605126774 no 1373 0.401105993102385 1826 25730
SGTC_2560 caryophyllene 100 µM 0.249980553313768 0.414113265826964 no 1374 0.401301193748898 1836 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2273 7815444 169.05 µM 0.248868972749007 0.414530926379357 no 1375 0.401731068236164 1998 2824616
SGTC_706 4262-0057 46.9 µM 0.248399271840652 0.414707438876524 no 1376 0.401912748458527 1829 883298
SGTC_2710 st078562 53.7235 µM 0.248263853031713 0.414758332146707 no 1377 0.401965132366706 1882 17250908
SGTC_1933 st074711 15.9 µM 0.247757809770818 0.414948526629684 no 1378 0.402160900101898 1987 17250958
SGTC_3282 9108498 15.4605 µM 0.247624966399458 0.41499845862373 no 1379 0.402212295915902 1838 16459645
SGTC_58 0957-0393 9 µM 0.246626314645764 0.415373866938415 no 1380 0.402598718678358 1847 6997992
SGTC_899 1083-0020 478 µM 0.246253911797719 0.41551387860447 no 1381 0.402742842281976 1965 767123
SGTC_1402 3909-7673 35.9 µM 0.243882766399847 0.416405604990272 no 1382 0.403660808333301 1869 5328014
SGTC_346 4513-0042 7.16 µM 0.240931839688893 0.417515972802821 no 1383 0.404803972194683 1841 2827372
SGTC_465 cgp-37157 41 µM 0.240111666660571 0.417824702835844 no 1384 0.4051218450293 2000 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3037 9091026 49.47 µM 0.239113841929593 0.418200372911676 no 1385 0.405508654377877 1934 25236398 YIL048W NEO1
SGTC_374 0880-0231 82.3 µM 0.239039903056372 0.418228213061527 no 1386 0.40553732065175 1945 6833587
SGTC_2058 5236698 133 µM 0.238152569338428 0.418562352099499 no 1387 0.405881381490175 1861 766665
SGTC_1092 toremifene 6.32 µM 0.238022749152998 0.41861124280308 no 1388 0.405931724959408 1994 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1023 4482-3888 16 µM 0.237191484433298 0.418924329565086 no 1389 0.406254121141488 1979 3303168
SGTC_2532 xanthone 78.9 µM 0.236720978205277 0.419101563360904 no 1390 0.406436629601152 1959 7020 An insecticide.
SGTC_3276 9139060 49.47 µM 0.236672193155126 0.419119941017522 no 1391 0.406455554391977 1906 4870619
SGTC_883 0850-0245 24.6 µM 0.236307171473109 0.419257452738186 no 1392 0.406597161238499 1963 6823229 YPR165W RHO1
SGTC_996 3970-0799 1.8 µM 0.236231136586772 0.419286097999102 no 1393 0.406626659819948 2004 6615648 YGL040C HEM2
SGTC_768 0384-0033 77.3 µM 0.23420842384832 0.420048288151478 no 1394 0.407411587795385 1826 3965305 YMR134W ERG29
SGTC_2706 st078239 82.5 µM 0.233334948760747 0.420377520281971 no 1395 0.407750661141776 1946 15434492
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.233318370950378 0.420383769365782 no 1396 0.40775709713308 1913 97141
SGTC_327 1273-0057 3.96 µM 0.232446916512621 0.420712296443672 no 1397 0.408095456266844 1987 3108138
SGTC_2114 5491910 81.25 µM 0.231097786031052 0.421221010085302 no 1398 0.408619417531835 1964 2849228
SGTC_2546 rhodinyl acetate 100 µM 0.2304015424785 0.421483592612163 no 1399 0.408889881335016 2026 6708682
SGTC_2434 5670830 169.91 µM 0.230119636141867 0.421589921205922 no 1400 0.408999403436654 1890 1549830
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.229935062732258 0.421659541153314 no 1401 0.409071115031159 1886 15053
SGTC_1422 4031-0024 15.5 µM 0.229481507534086 0.421830629763808 no 1402 0.409247346005458 1992 782427
SGTC_1008 4106-0037 6 µM 0.225404712157441 0.423369123823421 no 1403 0.410832223095948 1904 2905394
SGTC_524 r073-0010 27.8 µM 0.225200257168863 0.423446311678263 no 1404 0.410911744697855 1842 2772106
SGTC_1394 3474-0001 65.7 µM 0.224661893660535 0.423649574002008 no 1405 0.411121155620567 1896 5017666 YIL048W NEO1
SGTC_3343 9148379 18.9835 µM 0.224166311752587 0.423836701841118 no 1406 0.411313947884409 2016 1955036
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.223057015026401 0.424255625768789 no 1407 0.411745566275362 1928 521171
SGTC_1845 st056753 3.01 µM 0.221742998322307 0.424751972540854 no 1408 0.412256977713172 1820 5375839
SGTC_1511 0906-3109 28.5 µM 0.221381582888474 0.424888511842262 no 1409 0.4123976657058 1970 2882180
SGTC_950 1165-0508 94.1 µM 0.22066297431849 0.425160022058413 no 1410 0.412677431505372 1861 6148369
SGTC_1349 flufenamic acid 69 µM 0.220450771370203 0.425240205003484 no 1411 0.412760053995241 1905 3371 A non-steroidal anti-inflammatory.
SGTC_3098 9119039 49.47 µM 0.220130361735455 0.425361280754936 no 1412 0.412884814730064 1945 17161528
SGTC_2987 9018338 71.43 µM 0.218425356769342 0.426005682742978 no 1413 0.413548855311416 1946 5055682
SGTC_2907 7721985 69.9 µM 0.218417942250639 0.426008485472992 no 1414 0.413551743552003 1859 3267881
SGTC_863 0466-0191 129 µM 0.215945552255056 0.426943270440394 no 1415 0.414515094560104 2028 765160 YPR165W RHO1
SGTC_1295 1013-0063 9.78 µM 0.215845556761166 0.426981086368315 no 1416 0.41455406802959 2049 6826038
SGTC_2122 5258151 111.688 µM 0.214910894311015 0.427334585980362 no 1417 0.414918395457413 1918 2173356
SGTC_884 0851-0618 334 µM 0.214137692096862 0.427627063671945 no 1418 0.415219841705246 2024 9642473
SGTC_755 1995-0008 37.3 µM 0.213579541299266 0.427838219013779 no 1419 0.415437477472469 2028 689533
SGTC_1027 k015-0025 8.67 µM 0.21304436126443 0.428040703643016 no 1420 0.415646180780607 1870 3598955
SGTC_693 4161-2696 114 µM 0.212976141502626 0.42806651585879 no 1421 0.415672786044008 2004 805759
SGTC_850 0388-0143 75.9 µM 0.212645431998172 0.42819165031192 no 1422 0.415801766076687 1913 67273
SGTC_2397 5161689 200 µM 0.212639200447869 0.428194008286412 no 1423 0.415804196531088 1976 2259942
SGTC_2265 7929201 200 µM 0.212453622770592 0.428264230739638 no 1424 0.415876577761455 1862 1265108
SGTC_2979 9012552 45.46 µM 0.212013327496922 0.428430847223833 no 1425 0.41604831841548 2082 17100905
SGTC_551 k048-0028 34.9 µM 0.211922369250596 0.428465269223427 no 1426 0.416083799398087 2002 6836383
SGTC_2450 5739737 12.93 µM 0.210138768645574 0.429140359993179 no 1427 0.41677968396998 1933 2262825
SGTC_2249 haloperidol 116.36 µM 0.20915484853238 0.429512861477444 no 1428 0.417163679243524 1937 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3055 9094636 49.47 µM 0.208720400995033 0.429677358599478 no 1429 0.417333256597538 1987 25236176
SGTC_1112 tnp00069 1.16933 µM 0.207942705156986 0.429971852076474 no 1430 0.417636852005086 2021 145826
SGTC_1559 coumarin 343 70.1 µM 0.206308575988017 0.430590781664609 no 1431 0.418274939981488 2021 108770 A hepatotoxic, DNA x-linker.
SGTC_591 4299-0174 154 µM 0.203408507361818 0.431689607235195 no 1432 0.419407875446392 1978 5509088
SGTC_1413 3910-0535 34.4 µM 0.202990563220492 0.431848008559597 no 1433 0.419571204063088 2040 2876951
SGTC_799 1310-0557 151 µM 0.202342733899653 0.432093558286939 no 1434 0.419824397009649 1969 5354492
SGTC_3313 9133968 57.047 µM 0.201962224972503 0.432237796571981 no 1435 0.419973127858244 1985 1494643
SGTC_18 0111-0177 500 nM 0.201720598882775 0.432329393680148 no 1436 0.420067579023787 1954 721752
SGTC_3268 9137683 49.47 µM 0.201547948630147 0.432394845230866 no 1437 0.420135070489938 1923 1953228
SGTC_195 4234-0266 16.654 µM 0.201399229071943 0.432451226164923 no 1438 0.420193208986459 1941 2303354
SGTC_311 1315-0136 58 µM 0.201192849754605 0.432529468715415 no 1439 0.420273891126618 2035 6759207
SGTC_2941 9056145 11.23 µM 0.199906348256231 0.433017266844887 no 1440 0.420776912733994 2084 2119517
SGTC_1383 3049-0032 20.7 µM 0.196930690522437 0.434145926145394 no 1441 0.421940888185732 2045 712864
SGTC_2782 7736369 71.43 µM 0.196034458637469 0.434485970244208 no 1442 0.42229159756922 1934 2950836 YOL077C BRX1
SGTC_2235 salicylic acid 500 µM 0.195503898583122 0.43468729571039 no 1443 0.422499242970806 2068 338 A COX inhibitor and kinase inhibitor.
SGTC_1386 3228-0095 33.8 µM 0.194288266979261 0.435148641103985 no 1444 0.422975086093289 2035 870181
SGTC_128 0906-2981 13.371 µM 0.194189802607548 0.435186013276147 no 1445 0.423013633616119 2071 6740226
SGTC_2446 5162541 200 µM 0.19398973893151 0.435261949267727 no 1446 0.423091958217043 1921 1549321
SGTC_2835 9006588 71.43 µM 0.193385680906459 0.435491239471911 no 1447 0.423328464375827 1906 2345538
SGTC_919 tnp00227 403.569 nM 0.193135490553412 0.43558621385245 no 1448 0.42342642921963 1940 1269246 A methoxyflavone. YNL221C POP1
SGTC_3304 9125678 46.087 µM 0.192435041002715 0.435852130188644 no 1449 0.423700723271228 1933 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1328 1441-0025 69.2 µM 0.192274436476433 0.435913105648199 no 1450 0.423763620762448 1955 4562601
SGTC_2350 9023895 38.85 µM 0.190663746667043 0.436524707613387 no 1451 0.424394521774429 2001 2997209
SGTC_1715 st032160 10.2275 µM 0.190468553132553 0.436598835731195 no 1452 0.424470991528227 2049 5289825
SGTC_2278 7948257 134.34 µM 0.188464581101192 0.437360007053523 no 1453 0.425256239080393 2124 1247028
SGTC_1480 1070-0044 41.2 µM 0.187735998555486 0.437636803147596 no 1454 0.425541804605935 2072 3124987
SGTC_3244 9134489 49.47 µM 0.18723945565408 0.437825462461888 no 1455 0.425736445349835 1934 16584271
SGTC_1949 st076024 69.1 µM 0.186568544449938 0.438080394696753 no 1456 0.425999465774813 1888 2921930
SGTC_3148 9097893 49.47 µM 0.186451543234543 0.438124855347805 no 1457 0.426045337677638 1888 17174100
SGTC_1116 jasmonic acid 1.58368 µM 0.186101969291685 0.438257698662106 no 1458 0.426182398810801 2039 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2197 6588183 93.1375 µM 0.184085490049555 0.439024126224852 no 1459 0.426973194609883 1999 884136
SGTC_3030 9087619 49.47 µM 0.183823398293967 0.439123759449456 no 1460 0.427075999867915 1969 25236973
SGTC_88 0180-0332 8.668 µM 0.183544132283011 0.43922992564877 no 1461 0.427185547162794 2021 3101745
SGTC_2837 9008476 45.46 µM 0.183032862612756 0.439424302040671 no 1462 0.427386116759261 2005 2992805
SGTC_664 1222-0054 14.9 µM 0.181798983002861 0.439893463017862 no 1463 0.427870241334215 2009 6813991
SGTC_99 0109-0120 622.8 µM 0.181635915267082 0.439955472980338 no 1464 0.427934230675142 2071 759414
SGTC_3033 9090887 49.47 µM 0.180167258651528 0.440514026977296 no 1465 0.428510630801159 1957 19325384
SGTC_1513 0337-0559 19 µM 0.179931392577587 0.44060374174297 no 1466 0.428603214838639 1915 775073
SGTC_724 3910-0327 137 µM 0.179596581904528 0.440731096623815 no 1467 0.428734644147745 1955 2885483
SGTC_65 0798-0905 34.986 µM 0.177636690718179 0.441476720230166 no 1468 0.429504153874829 2102 3602145
SGTC_637 1181-0519 7.26 µM 0.177179284387822 0.441650766457263 no 1469 0.429683783444241 2045 6252091 YGR060W ERG25
SGTC_1834 st055981 52.8 µM 0.17681051451478 0.44179109411318 no 1470 0.429828614895803 2099 471719 YDL150W RPC53
SGTC_662 k832-1615 104 µM 0.176065995554823 0.442074427466011 no 1471 0.43012104758974 2024 5878478
SGTC_2704 st078022 71.1 µM 0.174604223370279 0.442630804036403 no 1472 0.430695314899199 2109 54697681
SGTC_2127 5253358 187.912 µM 0.17446265891071 0.442684692022796 no 1473 0.430750937280573 1975 20612
SGTC_3018 9082602 49.47 µM 0.173879674446048 0.442906622297118 no 1474 0.430980013364861 2005 17332089
SGTC_1497 4476-2978 41.3 µM 0.173587853471605 0.443017719311986 no 1475 0.431094689308127 2052 1528379
SGTC_1700 st030840 7.9285 µM 0.172458514842928 0.443447703647122 no 1476 0.431538536508599 2118 5499307
SGTC_1812 st052057 4.327 µM 0.172085368640874 0.443589789976203 no 1477 0.431685207651223 2031 3645418
SGTC_390 dec-rvkr-cmk 16.7 µM 0.171654656180385 0.443753805357703 no 1478 0.4318545178505 2023 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1934 st074720 32.6 µM 0.171557169264428 0.443790929730824 no 1479 0.431892841046229 2029 17250992
SGTC_3010 9080089 71.4286 µM 0.171233835313466 0.443914063324613 no 1480 0.432019951820734 2096 17027233
SGTC_3232 9132874 49.47 µM 0.170549897551613 0.44417454162555 no 1481 0.432288848269028 1966 3784940
SGTC_2957 9076800 11.52 µM 0.169426486100748 0.444602446155769 no 1482 0.432730595876931 1959 16459615
SGTC_2310 7668677 200 µM 0.168995716188412 0.444766542460707 no 1483 0.432900005461882 2050 2197143
SGTC_194 1486-1323 56.904 µM 0.168754940621567 0.444858266968663 no 1484 0.432994701036435 1964 5178754
SGTC_1352 1496-0991 99 µM 0.168384843195781 0.444999262961493 no 1485 0.433140265617016 1995 3000039
SGTC_1327 1436-0082 2.18 µM 0.168247745198254 0.445051494944153 no 1486 0.433194190512771 1988 15992205
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.167476465314517 0.445345357088749 no 1487 0.433497581973461 2055 5377381
SGTC_1109 tnp00067 928.257 nM 0.167100216145061 0.445488721130835 no 1488 0.433645597973342 1975 676295
SGTC_2457 5731572 11.68 µM 0.167064041463751 0.445502505320676 no 1489 0.433659829542977 2125 2865357
SGTC_2504 purpurogallin 52.29 µM 0.16661570746139 0.445673346317426 no 1490 0.433836216849487 1954 5281571 An antioxidant.
SGTC_1558 st069300 45.6 µM 0.165597550863694 0.446061359859326 no 1491 0.434236837404597 2117 24208000
SGTC_2961 9083290 32.55 µM 0.165322526483924 0.446166178923834 no 1492 0.434345064602198 2122 17741490
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.165221749207055 0.44620458875147 no 1493 0.434384723563352 1933 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2384 9036245 200 µM 0.16456252813754 0.446455853933158 no 1494 0.434644163620122 2087 6462766
SGTC_211 3455-0679 143.504 µM 0.16403965566846 0.446655164505033 no 1495 0.434849962961001 2013 748649
SGTC_1707 st032323 6.317 µM 0.163921901608915 0.446700052318776 no 1496 0.434896312661332 2042 3132057 YMR211W DML1
SGTC_2168 5727979 200 µM 0.16333118202566 0.446925244749115 no 1497 0.435128841918975 2108 695210
SGTC_3002 9075603 71.4286 µM 0.162494300653011 0.447244307553962 no 1498 0.435458308026712 2135 20105405
SGTC_1709 st033179 39.1045 µM 0.162092905308462 0.447397352512453 no 1499 0.435616346529478 2105 573381
SGTC_1660 st012960 28.1 µM 0.161987744623151 0.44743744972097 no 1500 0.435657752390839 2026 24207266
SGTC_2607 solasodine 47.35 µM 0.160133138477242 0.44814468906543 no 1501 0.436388098633357 1984 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_888 0916-0002 6.97 µM 0.15948636634686 0.448391369373564 no 1502 0.436642849458121 2098 2802138 YIL048W NEO1
SGTC_806 3966-4455 5.86 µM 0.159328616032173 0.448451538720236 no 1503 0.436704988195695 1959 714982
SGTC_3116 9124943 49.47 µM 0.157867766762293 0.449008794058603 no 1504 0.437280498955388 1914 41905195 YPL160W CDC60
SGTC_2518 prenyletin 46.28 µM 0.157348104586986 0.44920704862767 no 1505 0.437485255208544 2118 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3295 9122362 53.5725 µM 0.154445176027433 0.450314767052698 no 1506 0.438629367812946 1981 4730473
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.153882184254843 0.450529642221261 no 1507 0.438851315841373 2036 6708514
SGTC_10 0279-0212 42.575 µM 0.153580842604764 0.450644660233242 no 1508 0.438970121548452 2110 39851 YBR002C RER2
SGTC_782 0083-0095 30.5 µM 0.15213120884635 0.451198023495703 no 1509 0.439541724792881 2174 3591729 An indicator and reagent.
SGTC_175 3793-3120 23.7 µM 0.150288126375692 0.451901713289317 no 1510 0.440268650187526 2020 5322297
SGTC_2793 7325131 81.82 µM 0.149535130451698 0.452189251117096 no 1511 0.440565695445308 2052 4176441
SGTC_3324 9138759 60.749 µM 0.145391958139168 0.45377180093177 no 1512 0.442200706837672 2086 45595710
SGTC_2797 7859098 81.82 µM 0.141779301045851 0.45515231231586 no 1513 0.443627167130957 2048 972681
SGTC_3301 9125354 19.7965 µM 0.141716403066129 0.455176352484652 no 1514 0.443652008969858 2093 41905162
SGTC_2227 7312221 64.1025 µM 0.141385734305917 0.455302739731636 no 1515 0.443782611718083 2146 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1072 oxiconazole 14.9 nM 0.141100464723828 0.455411778272957 no 1516 0.443895288264396 2152 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2939 9044578 71.43 µM 0.140425081566639 0.455669943231478 no 1517 0.444162070983007 2088 2653634
SGTC_774 k060-0086 136 µM 0.139742937487956 0.45593071155082 no 1518 0.444431550013266 2171 5911235
SGTC_2677 mitomycin C 100 µM 0.139657071091808 0.455963537687928 no 1519 0.444465473105727 2098 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_742 0kpi-0133 140 µM 0.138491396199572 0.45640919688875 no 1520 0.44492603446649 2140 2728852
SGTC_820 1582-0060 59.9 µM 0.135596642032071 0.457516151272833 no 1521 0.446070080102524 2050 3848840
SGTC_2694 st077685 81.9 µM 0.134648566644451 0.45787876751298 no 1522 0.446444870298807 2079 2838096
SGTC_2301 7769476 200 µM 0.133567785719875 0.45829218321023 no 1523 0.446872179576456 2105 977820
SGTC_2920 7982904 15.77 µM 0.131893755006302 0.45893261519193 no 1524 0.447534164129359 2072 6456808
SGTC_19 0279-0214 38.434 µM 0.131348542482659 0.459141219606398 no 1525 0.447749796519759 2172 3566274 YBR002C RER2
SGTC_921 1561-0023 372 µM 0.130354672823001 0.459521514170551 no 1526 0.448142913184901 2200 24050882
SGTC_2179 6298986 200 µM 0.128966842903072 0.460052615696602 no 1527 0.448691942605393 2170 738374
SGTC_301 4119-0100 24.5 µM 0.128935267035835 0.460064700136507 no 1528 0.448704435254667 2075 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_832 4083-0019 164 µM 0.128621466837651 0.460184797008601 no 1529 0.448828589660676 2147 1990758
SGTC_1173 0443-0020 122 µM 0.127708432385786 0.460534252022447 no 1530 0.44918985833082 2065 5331295
SGTC_747 3448-8087 38.7 µM 0.127090092284696 0.460770932982618 no 1531 0.449434546542957 2072 5168703
SGTC_1882 5615643 20 µM 0.125513278780859 0.461374549846107 no 1532 0.450058606611137 2211 2253075
SGTC_1759 st043059 70 µM 0.125402593634875 0.461416924367104 no 1533 0.450102417450793 2062 669426
SGTC_2922 7999257 32.47 µM 0.12472342114854 0.461676947227755 no 1534 0.450371257393829 2181 2988377
SGTC_534 k292-0788 63.4 µM 0.122883255802808 0.462381541073646 no 1535 0.451099772530248 2229 4146317
SGTC_298 1391-0729 10 µM 0.122356914245187 0.462583097503388 no 1536 0.45130817975227 2100 3237558
SGTC_945 3381-0768 11.3 µM 0.121464574552305 0.462924830622667 no 1537 0.451661536159933 2187 1126236 YIL048W NEO1
SGTC_1233 0325-0408 14.2 µM 0.121334794958767 0.462974533695242 no 1538 0.451712930605392 2157 12874
SGTC_929 2805-0021 398 µM 0.119679987939906 0.463608343166554 no 1539 0.452368326855523 2087 3098024
SGTC_2784 7567673 72.73 µM 0.11929519334138 0.463755737069258 no 1540 0.452520745732484 2200 3471247
SGTC_1433 4060-0023 7.6 µM 0.118766060965168 0.463958427051953 no 1541 0.452730348875854 2166 3840627
SGTC_1199 1638-0010 4.46 µM 0.1168437078244 0.464694883932158 no 1542 0.453491953555771 2062 3111136
SGTC_1716 st033144 30.6155 µM 0.116670115326201 0.46476139351685 no 1543 0.453560736510658 2203 674617
SGTC_866 0495-0101 262 µM 0.116663416946895 0.464763959928747 no 1544 0.453563390652827 1984 635694
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.116406499515188 0.464862396181286 no 1545 0.45366519227325 2072 688669
SGTC_639 0833-0042 114 µM 0.115442832616478 0.465231638033008 no 1546 0.454047065183916 2084 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3181 9108277 49.47 µM 0.112394171966423 0.466399968776678 no 1547 0.455255438073148 2154 17097298
SGTC_2669 eugenol 100 µM 0.111671083249099 0.466677119157979 no 1548 0.45554210405518 2209 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_174 3553-0389 74.3 µM 0.111652878189733 0.466684097126542 no 1549 0.45554932168638 2154 738071
SGTC_1690 st023502 41.2 µM 0.11130581608185 0.466817127403389 no 1550 0.455686921750103 2216 24207482
SGTC_1270 0831-1170 17.3 µM 0.11079381722077 0.467013385353001 no 1551 0.455889924154989 2195 6764716
SGTC_844 0330-0132 15.3 µM 0.109704026658316 0.46743114742009 no 1552 0.456322053441474 2203 2828079
SGTC_1258 0671-0043 57.1 µM 0.109627611860252 0.467460441743026 no 1553 0.456352355769435 2093 4298767
SGTC_117 lucigenin 22.078 µM 0.109328864041374 0.467574971185429 no 1554 0.456470826807148 1981 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_585 0kpi-0023 191 µM 0.108718771827735 0.467808867483778 no 1555 0.456712776172619 2204 64601
SGTC_522 1273-0010 11.6 µM 0.107904447571965 0.468121079279934 no 1556 0.457035744536048 2133 5705015
SGTC_296 1222-0039 74.9 µM 0.107300925827238 0.468352482087974 no 1557 0.457275125040225 2119 5984176
SGTC_2667 digitoxin 100 µM 0.107040047703744 0.468452511509152 no 1558 0.457378604387116 2234 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1575 cyproterone acetate 48 µM 0.106208033788013 0.468771546820957 no 1559 0.457708648480407 2099 9880 An androgen receptor antagonist and liver toxin.
SGTC_3045 9092950 49.47 µM 0.105585235453493 0.469010371660295 no 1560 0.457955719832054 2230 44120432
SGTC_998 3996-0085 177 µM 0.104469570894689 0.469438224021154 no 1561 0.458398357513697 2181 715391
SGTC_2340 7987427 183.45 µM 0.1031729015725 0.469935535210483 no 1562 0.458912873264623 2159 2239331
SGTC_3233 9132340 49.47 µM 0.103051321118613 0.469982167341772 no 1563 0.458961119684615 2119 17682950
SGTC_1061 3448-9325 110 µM 0.102580632397536 0.470162703676593 no 1564 0.459147907422612 2240 723482
SGTC_2862 9027634 71.43 µM 0.102149401379685 0.470328111085867 no 1565 0.459319044714616 2181 5012562
SGTC_1727 st034309 9.9045 µM 0.102008250114209 0.470382253632146 no 1566 0.459375063301414 2232 870305
SGTC_2769 toremifene 3.73 µM 0.101500775165268 0.47057691446802 no 1567 0.459576471122627 2183 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2133 5320837 200 µM 0.100665554051506 0.470897309786537 no 1568 0.459907978157799 2213 2841355
SGTC_162 k030-0015 37.8 µM 0.100655241635292 0.470901265803111 no 1569 0.459912071426466 2201 1809920 YMR134W ERG29
SGTC_1818 st052136 56.3 µM 0.100250599977012 0.471056495422474 no 1570 0.460072687671167 2150 674169
SGTC_2951 9072950 58.06 µM 0.100206169811672 0.471073540099179 no 1571 0.460090323935232 2245 16488155
SGTC_952 1185-0122 232 µM 0.0991602706146214 0.47147479205396 no 1572 0.460505509398367 2224 678600
SGTC_615 k087-0205 167 µM 0.0977426568878057 0.472018695849984 no 1573 0.461068321203905 2172 9642773
SGTC_2086 5274770 176.623 µM 0.0974263760566289 0.472140052243611 no 1574 0.461193899648384 2141 689278
SGTC_1503 4585-0012 61.3 µM 0.0962510367590626 0.472591050422086 no 1575 0.461660598732753 2191 2922052
SGTC_396 dithiazanine 1.25 µM 0.0952369773768902 0.472980190946023 no 1576 0.462063299877943 2094 10578 An antihelmenthic.
SGTC_1735 st034310 56.75 µM 0.0951897497427297 0.47299831496013 no 1577 0.462082055768482 2159 871153
SGTC_1741 st038134 10.228 µM 0.0939450947242041 0.473475982150831 no 1578 0.462576385902317 2192 1272587
SGTC_1817 st052116 64.4 µM 0.0936119088660598 0.473603856976082 no 1579 0.462708724626139 2221 4361398
SGTC_3211 9128781 49.47 µM 0.0935611667407353 0.47362333175233 no 1580 0.462728879349815 1997 17194361
SGTC_1378 2093-0007 380 nM 0.092309589019558 0.474103705850372 no 1581 0.463226034982455 2147 3618014
SGTC_847 0342-0274 5.54 µM 0.0912364854690001 0.474515608924369 no 1582 0.463652342312271 2226 18097
SGTC_3095 9117207 49.47 µM 0.0905401107879077 0.47478292193665 no 1583 0.463929010512685 2236 17015229
SGTC_2359 9039622 200 µM 0.0894109237831704 0.475216399996422 no 1584 0.464377671159918 2189 6463596
SGTC_2972 9093619 59.92 µM 0.0888647824532355 0.47542606607012 no 1585 0.464594686157476 2071 25236256
SGTC_56 0957-0365 83.25 µM 0.0864289985869578 0.476361256318726 no 1586 0.465562697817636 2253 6752360
SGTC_1136 pergolide 1.05886 µM 0.0858717882092904 0.476575209104558 no 1587 0.465784169198525 2114 47811 A dopamine receptor agonist.
SGTC_1622 st003707 19.4 µM 0.0851521327539911 0.476851546120294 no 1588 0.466070222413784 2180 10140899
SGTC_1870 st057514 26.5 µM 0.0827760888931369 0.477763990032847 no 1589 0.467014791081991 2230 5393161
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0826208289069126 0.477823616791295 no 1590 0.46707651941247 2232 5282309
SGTC_3203 9113543 49.47 µM 0.0823581426466217 0.47792450115938 no 1591 0.467180960128502 2177 17018012
SGTC_1461 k072-0203 53.8 µM 0.0818184208560925 0.478131785148775 no 1592 0.467395553730431 2249 5418714
SGTC_856 0433-0016 11.3 µM 0.0800798236823612 0.478799545688495 no 1593 0.468086884786791 2167 3911780
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0781403851434429 0.479544515534942 no 1594 0.468858191343671 2246 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0779367135406464 0.479622753297255 no 1595 0.468939197516863 2262 2346 DNA damaging agent; causes G2/M arrest.
SGTC_458 nppb 133 µM 0.0776761975632455 0.479722828220934 no 1596 0.46904281423975 2266 4549 A chloride channel blocker.
SGTC_2200 6600604 21.907 µM 0.076973854253789 0.479992633582376 no 1597 0.469322172262779 2255 2904777
SGTC_980 1473-0395 201 µM 0.0766055548411881 0.480134119567268 no 1598 0.469468669908824 2231 768876
SGTC_2948 9070189 9.45 µM 0.0764313506866099 0.48020104274733 no 1599 0.469537964152738 2274 6473636 YDL196W YDL196W
SGTC_226 1,3-diallylurea 8.28947 mM 0.0757106962747199 0.480477899027862 no 1600 0.469824633012127 2214 74537 YKL182W FAS1
SGTC_1523 st012844 44.7 µM 0.0755097842030396 0.480555085792891 no 1601 0.469904556547434 2150 4274103
SGTC_1676 st018489 23.4 µM 0.0741154683081212 0.48109077653772 no 1602 0.470459253591291 2112 3696235
SGTC_1207 2099-0101 141 µM 0.0738429456821297 0.481195482690517 no 1603 0.470567677285242 2278 5837381
SGTC_2418 pentamidine 31.67 µM 0.0737300887931144 0.481238843913292 no 1604 0.470612578272766 2285 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1603 st002045 67.8 µM 0.0723761117102888 0.48175907833573 no 1605 0.471151297510732 2284 5887985
SGTC_3256 9138902 49.47 µM 0.0714292990219204 0.482122887752525 no 1606 0.471528045955314 2291 17228773
SGTC_3082 9117008 49.47 µM 0.0712247563007222 0.482201484533449 no 1607 0.471609439384882 2164 41448529
SGTC_2167 5876490 200 µM 0.0708630832671675 0.482340461280776 no 1608 0.471753362383329 2237 686534
SGTC_2406 ethylparaben 405.7 µM 0.070447223657015 0.482500262453346 no 1609 0.471918852770899 1968 8434 A possible steroid mimic.
SGTC_368 fentichlor 4.58 µM 0.0699274333145124 0.482700004738827 no 1610 0.472125708971305 2189 7329 A pesticide.
SGTC_3077 9117319 49.47 µM 0.0687482680340198 0.48315314416056 no 1611 0.472594998363039 2299 17154678
SGTC_379 3970-0972 5.9 µM 0.0678449511424811 0.483500293025686 no 1612 0.472954530168025 2195 2898042 YBL034C STU1
SGTC_2371 9071574 200 µM 0.0676472833683821 0.483576259343935 no 1613 0.473033207447025 2283 45596039
SGTC_881 0833-0569 170 µM 0.0657270013243271 0.484314279532896 no 1614 0.473797587470586 2133 5418700
SGTC_663 1486-0733 13.9 µM 0.0650598380569161 0.484570702470492 no 1615 0.474063178619812 2231 722445 YPR165W RHO1
SGTC_3335 9143315 29.6265 µM 0.0631401878249734 0.485308551623694 no 1616 0.474827436434189 2186 4899691
SGTC_40 0327-0103 19.753 µM 0.0623900406765801 0.485596896832147 no 1617 0.475126112949401 2258 409036
SGTC_1078 idebenone 36.1 µM 0.05931581348038 0.486778660277479 no 1618 0.476350282977715 2238 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1820 st053765 18.6 µM 0.0585420826707547 0.487076108776575 no 1619 0.476658421414906 2237 3690829
SGTC_2750 bromebric acid 70.15 µM 0.0578082540285734 0.487358224167994 no 1620 0.476950681706033 2252 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0572077354502192 0.48758909413223 no 1621 0.477189858127863 2173 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1118 chelidonine 707.474 nM 0.0570233091623635 0.487659997840266 no 1622 0.477263313661144 2308 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2608 thymoquinone 42.66 µM 0.0570024118438505 0.487668031954777 no 1623 0.477271636946768 2322 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3154 9100113 49.47 µM 0.056693066806643 0.487786962316434 no 1624 0.47739484851064 2243 25237525
SGTC_683 panaxydol 45 µM 0.0566275727995787 0.487812142190735 no 1625 0.477420934931723 2284 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1992 st073643 23.3 µM 0.0561169647259793 0.4880084526057 no 1626 0.477624314668535 2313 3161292
SGTC_1540 guanosine 70.6 µM 0.0554287231132683 0.488273061307711 no 1627 0.477898456635444 2302 6802 Guanosine is a purine nucleoside
SGTC_2641 levomentholum 100 µM 0.0552895670502411 0.488326563361232 no 1628 0.477953886870689 2286 16666
SGTC_1545 lovastatin 49.4 µM 0.0550987562131766 0.488399925735042 no 1629 0.478029893519664 2267 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1222 0366-0074 1.18 µM 0.0546317084268165 0.488579496507119 no 1630 0.478215938400526 2301 286520
SGTC_904 1141-0088 396 µM 0.053388716552303 0.489057413841201 no 1631 0.478711097639421 2161 1378119
SGTC_3204 9114183 49.47 µM 0.0531623218769138 0.489144461930155 no 1632 0.478801287963696 2293 17027248
SGTC_1954 st077032 68.9 µM 0.0530976187341791 0.489169340194034 no 1633 0.478827064376569 2105 698907
SGTC_2286 7945697 125 µM 0.0516246571225815 0.489735702991339 no 1634 0.479413885995114 2257 1245733
SGTC_1844 rapamycin 4 nM 0.0515324568773255 0.489771155252778 no 1635 0.479450619676506 2252 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_528 3492-0019 172 µM 0.0498238801288333 0.490428140822682 no 1636 0.480131368361059 2319 2869262
SGTC_625 k213-0058 121 µM 0.0491491086279355 0.490687612649665 no 1637 0.480400233821568 2258 3655420
SGTC_2328 6201408 200 µM 0.0490722551078772 0.490717165606927 no 1638 0.480430856988452 2268 2890418
SGTC_1602 st001878 87.6 µM 0.048117264912288 0.491084398066111 no 1639 0.48081139336609 2287 595405 YLR310C CDC25
SGTC_889 0919-1524 82.7 µM 0.0477306209855115 0.49123308050283 no 1640 0.480965464944927 2176 3905452
SGTC_2402 5553605 200 µM 0.047165975368839 0.491450214988293 no 1641 0.481190472524869 2287 6758546
SGTC_1808 st050063 61.5 µM 0.0470120029086797 0.491509425543886 no 1642 0.48125183058461 2317 4011993
SGTC_858 0438-0351 2.77 µM 0.0468165103240623 0.491584603053017 no 1643 0.481329735062973 2234 2799119
SGTC_3330 9141424 71.43 µM 0.0467674228131596 0.491603479912237 no 1644 0.481349296719776 2309 27261020
SGTC_2137 5261020 140 µM 0.0457675825322474 0.491987977757952 no 1645 0.481747748557281 2327 763655
SGTC_2233 sulbentine 40.3845 µM 0.0453080195922237 0.49216470946423 no 1646 0.481930897647132 2307 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1526 st051518 75 µM 0.0450435171844845 0.492266428465641 no 1647 0.482036311218993 2167 673993
SGTC_1801 st050089 28.441 µM 0.0450239168038094 0.492273966153035 no 1648 0.482044122714543 2318 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2865 9030313 51.95 µM 0.0443961031004976 0.492515404920597 no 1649 0.48229433393165 2318 42562754
SGTC_375 3970-0961 9.27 µM 0.0442365174663521 0.492576777323324 no 1650 0.482357936901652 2284 2898222
SGTC_2023 5144124 124 µM 0.0441561981458502 0.49260766607051 no 1651 0.482389948394939 2303 2830192
SGTC_2238 6671620 73.2395 µM 0.0428620274224605 0.493105376864832 no 1652 0.482905759321358 2335 729941
SGTC_1916 st067606 49.2 µM 0.0428610916655313 0.493105736741208 no 1653 0.48290613229161 2295 19590279
SGTC_971 1315-0384 26.7 µM 0.042641876391974 0.493190043402524 no 1654 0.482993506649479 2284 6769120
SGTC_914 3820-6779 408 µM 0.0421659820039871 0.493373065756478 no 1655 0.483183190428824 2334 2893481
SGTC_399 oxolinic acid 75 µM 0.041310192746722 0.49370219387061 no 1656 0.483524303685587 2244 4628 A DNA gyrase inhibitor.
SGTC_3145 9085516 49.47 µM 0.0387332864982182 0.494693271601086 no 1657 0.484551517262894 2217 25236195
SGTC_1145 3546-0597 10.2 µM 0.0386927754634648 0.494708852416108 no 1658 0.484567666721356 2245 875334
SGTC_797 k781-0471 270 µM 0.0382219344625095 0.494889941601342 no 1659 0.484755366250106 2270 23738129
SGTC_2199 6590217 200 µM 0.0379711131103049 0.49498640991601 no 1660 0.484855356905257 2311 703109
SGTC_120 rhodamine 6G 52.259 µM 0.0376417756459409 0.495113076730104 no 1661 0.484986649680013 2342 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2269 7935389 174.42 µM 0.0370121802711139 0.49535522740223 no 1662 0.485237646971837 2341 97605
SGTC_1408 3909-7976 48.8 µM 0.0354807988142849 0.495944223843009 no 1663 0.485848178530389 2320 24152374
SGTC_421 streptovitacin 30 mM 0.0334102461161268 0.49674060891502 no 1664 0.486673719503089 2251 91467 include heat shock
SGTC_760 0568-0725 82.9 µM 0.0323853695141897 0.497134806458225 no 1665 0.487082364902618 2350 3916171
SGTC_2737 bleomycin 30.5 nM 0.0319973218412132 0.497284061703861 no 1666 0.487237093333235 2341 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3319 9138450 16.7555 µM 0.0316182164994409 0.497429877817115 no 1667 0.487388257993318 2252 2029690
SGTC_430 0958-0115 16.4 µM 0.0311283089462346 0.497618312532023 no 1668 0.487583606665113 2218 6833180
SGTC_412 gemfibrozil 100 µM 0.0309201234076482 0.497698387767374 no 1669 0.487666620718263 2353 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2598 perillyl alcohol 100 µM 0.0302522704800874 0.497955267316649 no 1670 0.487932930885435 2319 10819 An apoptosis inducer.
SGTC_2428 5615643 7.78 µM 0.0297317251500493 0.498155487815063 no 1671 0.488140505044565 2323 2253075
SGTC_2173 5763948 167 µM 0.0291278434854026 0.498387763050614 no 1672 0.488381314662636 2360 2867177
SGTC_1984 st072354 53.1 µM 0.0283822311830082 0.498674553879846 no 1673 0.488678647977202 2303 5762938
SGTC_1144 3486-0183 12.5 µM 0.0277973192468622 0.498899533727536 no 1674 0.488911902034501 2278 6744069
SGTC_2525 harmine 47.85 µM 0.0272827684231599 0.499097450250403 no 1675 0.489117100279755 2336 5280953 A monoamine oxidase inhibitor
SGTC_2555 cholic acid 100 µM 0.0264472629386537 0.499418819034766 no 1676 0.489450298472236 2312 6708657 Influences liver metabolism.
SGTC_61 0978-8327 98.565 µM 0.0255673756327855 0.499757259244225 no 1677 0.489801204016289 2362 6150059 YHR072W ERG7
SGTC_79 0052-0007 94.094 µM 0.0249362910377759 0.5 no 1678 0.490052890082329 2364 2801472
SGTC_362 0310-0100 9.03 µM 0.0249338628668201 0.499999066026815 no 1679 0.490053858481286 2334 790235
SGTC_809 3998-0021 90 µM 0.0243906150215916 0.499790110847758 no 1680 0.490270517114091 2367 715485
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0241759814875823 0.499707554088382 no 1681 0.490356118263133 2342 688761
SGTC_550 4123-0385 25.7 µM 0.0240817159624288 0.499671295749214 no 1682 0.490393713821002 2326 5731123
SGTC_787 4152-0075 138 µM 0.0236266578973137 0.499496262028961 no 1683 0.490575204078306 2301 9566539
SGTC_2258 7960471 200 µM 0.0235488592596878 0.499466337537945 no 1684 0.49060623261114 2267 2974708
SGTC_2896 9052656 71.43 µM 0.0233928728282159 0.499406338879963 no 1685 0.490668445055556 2364 6469436
SGTC_2773 thioridazine 9.09 µM 0.0207158590461316 0.498376654896194 no 1686 0.491736159022729 2374 5452 An antipsychotic.
SGTC_1201 1889-3372 45.9 µM 0.019719435478364 0.497993393897046 no 1687 0.49213359326209 2320 5392199
SGTC_1171 0368-0077 21.4 µM 0.0191776956826161 0.497785021684438 no 1688 0.492349675298925 2361 3239779
SGTC_1004 4084-0029 199 µM 0.0191553856303291 0.497776440464842 no 1689 0.492358574087397 2362 716894 YLR208W SEC13
SGTC_235 0330-0087 5 mM 0.0176889295835835 0.497212393071641 no 1690 0.492943506090059 2371 46494818 YHR062C RPP1
SGTC_2739 tacrine 100.86 µM 0.0175658474092963 0.497165051843137 no 1691 0.492992601145196 2348 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_147 4466-0538 29.23 µM 0.016971642627697 0.496936502795227 no 1692 0.493229619209146 2322 6742687 YHR072W ERG7
SGTC_1888 azatryptophan 97.5 µM 0.0168285391681943 0.496881461043881 no 1693 0.493286701077319 2292 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1903 st060211 78.3 µM 0.0165645949634569 0.496779940584898 no 1694 0.493391984903659 2371 688960
SGTC_1296 1068-0102 11.9 µM 0.0160060704316125 0.496565116837238 no 1695 0.493614774405968 2370 767053
SGTC_2028 5153890 36.43 µM 0.0145280752728368 0.495996644612777 no 1696 0.494204340398316 2376 2830968 YPR165W RHO1
SGTC_2873 9040596 71.43 µM 0.0141988423809124 0.495870014848643 no 1697 0.494335671770293 2281 6463863
SGTC_2966 9084041 48.03 µM 0.0118817522440165 0.494978826663895 no 1698 0.495259978194451 2387 17741380
SGTC_191 3914-0123 66.505 µM 0.0112289276100231 0.494727744691404 no 1699 0.495520400150899 2384 3144412
SGTC_3293 9120939 62.045 µM 0.0103108800292884 0.494374659247617 no 1700 0.495886626893327 2385 934087
SGTC_3243 9134147 49.47 µM 0.00967817525126336 0.494131320544541 no 1701 0.496139026969573 2389 24282180
SGTC_1260 0700-1617 7.75 µM 0.00810443366145648 0.493526068086793 no 1702 0.496766834147158 2376 2853078
SGTC_1121 fusaric acid 630.51 nM 0.00748736375399881 0.493288750346363 no 1703 0.497013001938636 2388 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_576 1073-0113 22.7 µM 0.00646503937687226 0.492895581829261 no 1704 0.497420840414859 2392 5439563
SGTC_688 0527-0193 473 µM 0.00576927219354889 0.492628005562252 no 1705 0.497698406162757 2394 4007154
SGTC_2513 baicalein 25.65 µM 0.00497270360898013 0.492321667444059 no 1706 0.498016186458361 2394 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_29 0299-0004 12.984 µM 0.00486356223672198 0.492279695057141 no 1707 0.49805972703969 2393 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1846 st056244 14.8 µM 0.00433747578695215 0.492077379731643 no 1708 0.49826960294423 2367 5393182
SGTC_118 0083-0097 135.343 µM 0.00379513763869242 0.491868816678251 no 1709 0.498485962770448 2396 5207356
SGTC_2145 5634607 200 µM 0.00319272941326826 0.49163715551873 no 1710 0.498726287411102 2397 308662
SGTC_2242 6630449 61.2675 µM 0.00212468199743792 0.491226435867993 no 1711 0.499152375156549 2387 691249 YDR170C SEC7
SGTC_1286 0929-0070 131 µM 0.00163520535774765 0.49103820978394 no 1712 0.499347647736376 2400 1420408
SGTC_1944 st076371 56.9 µM -0.000315679776798501 0.490288025747245 no 1713 0.499874061992059 2406 24208455
SGTC_1098 clofazimine 15.1 µM -0.000442184433604331 0.490239381409222 no 1714 0.499823593939449 2406 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2568 diosmetin 100 µM -0.000902435012678537 0.490062404294905 no 1715 0.499639980566994 2407 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_466 geldanamycin 89.2 µM -0.000993769897367155 0.490027284126684 no 1716 0.499603543236205 2408 5288382 HSP90 inhibitor.
SGTC_2887 9044784 58.44 µM -0.00244548982878501 0.48946907809577 no 1717 0.499024391683431 2407 6465546
SGTC_2451 5856223 45.7 µM -0.00313558811978896 0.489203733095947 no 1718 0.498749083374909 2412 2179896
SGTC_1705 st027868 56.3335 µM -0.00366331261475054 0.48900082455794 no 1719 0.498538552980384 2418 292948
SGTC_1108 betulinic acid 729.144 nM -0.0047438900574703 0.488585354604353 no 1720 0.498107468780911 2418 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2483 5729050 27.16 µM -0.00496408313942778 0.488500694329035 no 1721 0.498019625485696 2414 2865180
SGTC_2522 biochanin a 4.94 µM -0.00519107103319397 0.488413422113335 no 1722 0.497929071585256 2417 5280373 A possible chelator.
SGTC_2634 4'-methoxyflavone 100 µM -0.00581724102635961 0.488172675410659 no 1723 0.497679269688339 2417 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3270 9137563 49.47 µM -0.00728745667547057 0.487607431354945 no 1724 0.49709275114814 2471 17015724
SGTC_116 0155-0182 31.788 µM -0.00892358762548761 0.486978428259584 no 1725 0.496440050850094 2422 771486
SGTC_3318 9139014 38.6185 µM -0.00937850099438229 0.486803544574229 no 1726 0.496258574273616 2422 16643984
SGTC_2995 9067767 71.4286 µM -0.00957630917359792 0.486727501383354 no 1727 0.496179663771645 2433 11673567
SGTC_1271 0832-2808 169 µM -0.0128544451920269 0.485467363347053 no 1728 0.494871959545652 2431 3663794
SGTC_2409 alverine citrate 63.97 µM -0.0130672959494265 0.485385546933103 no 1729 0.494787051511173 2536 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2376 9072922 81.32 µM -0.0134295267841401 0.485246312631865 no 1730 0.49464255499833 2487 17087968
SGTC_932 2857-0803 154 µM -0.0142119580616086 0.484945567830589 no 1731 0.494330439898632 2488 674898
SGTC_1204 4049-0315 18.3 µM -0.0167806113719931 0.483958310121754 no 1732 0.493305818802075 2511 588402
SGTC_486 niguldipine 82 µM -0.0175132264780561 0.483676748460304 no 1733 0.493013590630698 2426 1236 A calcium channel blocker.
SGTC_383 2324-0395 7.37 µM -0.0184224820720633 0.483327310933185 no 1734 0.492650908692579 2461 3146421
SGTC_3334 9142812 21.919 µM -0.0188718634955986 0.483154613124023 no 1735 0.492471662610381 2499 45283678
SGTC_561 1550-0330 72.9 µM -0.019995539195855 0.482722797134215 no 1736 0.49202346553067 2459 6812934
SGTC_1990 st072050 59.8 µM -0.0205221721204858 0.482520424942006 no 1737 0.491813412502745 2440 17233948
SGTC_2363 9053361 176 µM -0.0205349872503819 0.482515500455972 no 1738 0.491808301082748 2451 6469797 YMR079W SEC14
SGTC_1733 st037357 54.9 µM -0.0206975166119161 0.482453045326124 no 1739 0.491743475026665 2454 1272339 YGL099W LSG1
SGTC_1482 3346-2049 8.48 µM -0.0209595858119653 0.482352340947217 no 1740 0.491638947218706 2485 3826804
SGTC_2934 9036370 36.88 µM -0.0214406696717138 0.482167479536418 no 1741 0.491447065653474 2469 6462800
SGTC_1225 1216-0074 20.6 µM -0.0221330729068028 0.48190142322702 no 1742 0.491170902284128 2472 4241466
SGTC_2651 TUB2.036 5 µM -0.0222538823751949 0.48185500294741 no 1743 0.491122718147363 2461 15992207 YFL037W TUB2
SGTC_172 1112-0046 2.638 µM -0.0226430394135536 0.481705473474853 no 1744 0.490967506065229 2452 2802135 YIL048W NEO1
SGTC_2756 carbadox 75.1 µM -0.02295951430874 0.481583873243021 no 1745 0.490841283665046 2464 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1424 4048-1941 275 µM -0.0232384233761186 0.48147670847777 no 1746 0.490730044726456 2487 X1424
SGTC_512 prima-1 270 µM -0.0232436311186388 0.481474707528262 no 1747 0.490727967698803 2472 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1374 2889-5571 141 µM -0.02402194615754 0.48117566401444 no 1748 0.490417551627289 2481 2853281
SGTC_24 0417-1663 219 µM -0.0252651353022017 0.480698029025441 no 1749 0.489921741523481 2466 4329390
SGTC_2327 6189656 200 µM -0.025349725554788 0.48066553033252 no 1750 0.489888005700279 2470 5349088
SGTC_2343 7990716 14.84 µM -0.0258668720608116 0.480466850840098 no 1751 0.489681761733097 2456 6456862
SGTC_616 4092-0450 108 µM -0.0264633755771248 0.480237689671264 no 1752 0.489443872708539 2475 787165
SGTC_1167 k781-0610 148 µM -0.0297678799506779 0.478968305242201 no 1753 0.488126087747388 2479 4525169
SGTC_169 k015-0017 16.025 µM -0.0303400526048042 0.478748533506711 no 1754 0.487897926952429 2466 1840002
SGTC_1752 st044819 83.042 µM -0.0303780388340023 0.478733943209521 no 1755 0.487882779621571 2481 441209 YML126C ERG13
SGTC_319 1348-1596 45.5 µM -0.0305906630319626 0.478652275976568 no 1756 0.487797994243823 2486 5380505
SGTC_509 pifithrin 175 µM -0.0307741052078049 0.478581818042135 no 1757 0.487724845843349 2459 4817 A p53 inhibitor.
SGTC_3069 9117009 49.47 µM -0.0338617483669511 0.477395993612644 no 1758 0.48649369803225 2462 41904981
SGTC_2074 5212007 75.395 µM -0.0345703607348484 0.477123875425815 no 1759 0.486211168036959 2458 758611
SGTC_2899 9053889 58.44 µM -0.0347318069820551 0.477061879039505 no 1760 0.486146798958508 2476 6470052
SGTC_1777 st045864 34.765 µM -0.035989314592187 0.476579007233684 no 1761 0.485645439578091 2472 4691462
SGTC_2477 5967686 25.23 µM -0.0383613497246391 0.47566826089417 no 1762 0.484699788368024 2491 776118
SGTC_1311 1190-0148 100 µM -0.0387653727602703 0.475513148199724 no 1763 0.484538726302828 2503 1961333
SGTC_2282 7944268 200 µM -0.0388196784513219 0.475492299418292 no 1764 0.484517077761746 2505 2970414
SGTC_2521 angolensin 13.4 µM -0.0391387701209241 0.475369796626518 no 1765 0.484389875275124 2532 821428 A flavenoid.
SGTC_2854 9024559 71.43 µM -0.0401201670503438 0.474993042223791 no 1766 0.483998661881752 2508 3163529
SGTC_3040 9091894 49.47 µM -0.0403049846507114 0.474922093969155 no 1767 0.483924989916666 2505 25236966
SGTC_1049 3226-0134 66 µM -0.0404912304994201 0.474850598239364 no 1768 0.483850749178603 2466 5702385
SGTC_1325 1431-0015 227 µM -0.0408851029676395 0.474699401837164 no 1769 0.483693746813582 2482 1103340
SGTC_2749 bexarotene 57.39 µM -0.0426934201380526 0.474005287572456 no 1770 0.482972962379106 2507 82146 An retinoic acid receptor inhibitor.
SGTC_3314 9135860 59.4275 µM -0.0427437665074414 0.473985963468397 no 1771 0.482952895401944 2485 25252478
SGTC_1151 3909-8316 15.3 µM -0.0430021435250449 0.473886793341595 no 1772 0.482849912574996 2568 800431
SGTC_1303 1160-0052 261 µM -0.043245854981763 0.473793253625363 no 1773 0.482752776134253 2481 3562476
SGTC_265 mycophenolic acid 32.932 µM -0.0443793696303181 0.473358214615071 no 1774 0.482301003047182 2512 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2386 9075165 157.42 µM -0.0448204215051743 0.473188948985852 no 1775 0.482125223720626 2495 16452277
SGTC_360 0957-0399 1.01 µM -0.0461549738572383 0.472676807904951 no 1776 0.481593364928797 2523 6752301 YPR165W RHO1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0463967694929213 0.472584022439398 no 1777 0.481497005656582 2535 688751
SGTC_171 k064-0041 9.68 µM -0.0480464728401154 0.471951013367448 no 1778 0.480839602689848 2493 53325
SGTC_1353 1498-1206 8.11 µM -0.0487592373067343 0.471677539732051 no 1779 0.48055558371409 2480 6756808
SGTC_1166 k206-0078 225 µM -0.0510432436701788 0.470801302230294 no 1780 0.47964553098677 2497 5404595
SGTC_1448 4255-0083 152 µM -0.0535827928538686 0.469827194267735 no 1781 0.478633783064257 2547 5399660
SGTC_765 1319-0117 244 µM -0.0555994917463646 0.469053767016604 no 1782 0.477830434703957 2512 3487746 YGL099W LSG1
SGTC_1188 1403-0014 4.57 µM -0.0557065520727858 0.469012711386627 no 1783 0.477787789905368 2519 9614867
SGTC_702 1488-0190 94 µM -0.0559889491742144 0.468904418969418 no 1784 0.477675305317069 2498 949357
SGTC_355 1311-2252 105 µM -0.0567002878309547 0.46863164811639 no 1785 0.477391972365155 2523 5338538
SGTC_1755 st041960 45.185 µM -0.0569877204897455 0.468521432982312 no 1786 0.477277488437253 2566 2257073
SGTC_1596 piperlongumine 63 µM -0.0570757257179104 0.468487688140952 no 1787 0.477242436482532 2515 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2883 9059145 45.46 µM -0.0573956760890881 0.468365007856033 no 1788 0.477115003653645 2498 16476510
SGTC_353 1988-1175 58.3 µM -0.0576344351628546 0.468273461141933 no 1789 0.477019909978726 2458 2788357
SGTC_2558 carylophyllene oxide 100 µM -0.0580941081336576 0.468097214767699 no 1790 0.476836833748509 2490 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2914 7968218 45.32 µM -0.0581507414826158 0.468075501017949 no 1791 0.476814278441678 2551 2977111
SGTC_1996 st072960 66.8 µM -0.0585217692776528 0.467933247882338 no 1792 0.476666511416279 2483 1719405
SGTC_670 4204-0025 119 µM -0.0586199619935737 0.467895601193982 no 1793 0.476627405325475 2591 719039
SGTC_2250 alverine citrate 130 µM -0.0587371740105149 0.467850662958848 no 1794 0.476580724929761 2486 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1399 3562-5772 25 µM -0.0627616069076104 0.466307977010448 no 1795 0.474978169408216 2515 23847490
SGTC_3158 9100007 49.47 µM -0.0637666628529356 0.465922786964122 no 1796 0.474578011701808 2536 19297233
SGTC_1905 st060207 84.5 µM -0.0640851337581279 0.465800738886232 no 1797 0.474451219527445 2513 1948547
SGTC_2720 fluspirilene 36.88 µM -0.0660987976570601 0.465029114414072 no 1798 0.47364958404526 2586 3396 An atypical antipsychotic.
SGTC_2455 5377712 9.75 µM -0.0661122195785406 0.465023971648534 no 1799 0.473644241160099 2587 2243908
SGTC_46 0329-0187a 2.197 µM -0.0679816198114346 0.464307746633915 no 1800 0.472900132848421 2548 46494817
SGTC_1616 st002734 56.1 µM -0.068104205652533 0.464260784223958 no 1801 0.472851341252884 2555 4026101
SGTC_1229 0139-0193 12.2 µM -0.0685365236047005 0.464095167991363 no 1802 0.472679273391686 2530 3090752
SGTC_2565 isoliquiritigenin 100 µM -0.070915355155982 0.463183975961335 no 1803 0.471732561248303 2653 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1385 3091-4834 14.1 µM -0.0711278138829914 0.463102604702055 no 1804 0.471648015974473 2594 4072814
SGTC_1677 st019204 53.9 µM -0.0715731052132766 0.462932064043065 no 1805 0.47147082204894 2652 3945625
SGTC_983 1491-0821 12.2 µM -0.0725968088340613 0.462540025052891 no 1806 0.471063483101433 2601 46495113
SGTC_1974 st069448 26.9 µM -0.0732849924353768 0.462276497713443 no 1807 0.470789666943599 2551 6323587 YNR016C ACC1
SGTC_1476 4112-3294 3.34 µM -0.0753038938569202 0.461503492260929 no 1808 0.46998646171591 2649 704369
SGTC_2165 5727197 32.143 µM -0.075910081970296 0.461271420663364 no 1809 0.469745317876549 2888 1361712
SGTC_3185 9108267 49.47 µM -0.0774948997319871 0.460664755355744 no 1810 0.469114924249221 2593 4910486
SGTC_495 decylubiquinone 155 µM -0.0775562818334319 0.460641260233238 no 1811 0.469090509812084 2595 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2537 larixol 68.93 µM -0.0776329594104822 0.460611910680603 no 1812 0.469060011836002 2529 6708759
SGTC_1581 himbacine 57.9 µM -0.0777799831540323 0.460555635622928 no 1813 0.469001534666535 2525 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3227 9130768 49.47 µM -0.0777835186084997 0.460554282396096 no 1814 0.469000128484409 2560 17720899
SGTC_1280 0880-0253 10.1 µM -0.0784849980816102 0.460285793909035 no 1815 0.468721131603298 2581 6836607
SGTC_86 0417-1630 471.922 µM -0.0792352345063897 0.459998663932766 no 1816 0.468422759798951 2532 3634867
SGTC_566 0958-0068 16.5 µM -0.0806658000331818 0.459451216797313 no 1817 0.467853867885203 2596 6815365
SGTC_829 1635-0120 117 µM -0.080713495157181 0.459432966201787 no 1818 0.467834902125594 2634 285054
SGTC_1434 4073-0095 163 µM -0.0812574397226956 0.459224831227812 no 1819 0.467618610098556 2571 24133745
SGTC_1729 st035615 45.989 µM -0.0817279110907089 0.459044819052873 no 1820 0.467431541379234 2690 17385451
SGTC_214 4373-3496 70 µM -0.0858068421535433 0.457484490729797 no 1821 0.465809983645264 2590 3779166
SGTC_359 0081-0058 15.9 µM -0.0866699338691488 0.457154412284257 no 1822 0.46546693787922 2754 3494159
SGTC_3119 9125183 49.47 µM -0.0869750802365126 0.457037719998563 no 1823 0.465345660059611 2530 22695334
SGTC_3284 9108171 64.8615 µM -0.0874635572113913 0.45685092721156 no 1824 0.465151525759497 2631 8687505
SGTC_1791 st048313 56.1 µM -0.0885657884309301 0.456429470906141 no 1825 0.464713499040388 2577 1204976
SGTC_1269 0831-0796 3.05 µM -0.0888304419179837 0.45632828355474 no 1826 0.464608332082716 2607 927758
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0888426431944043 0.456323618599074 no 1827 0.464603483647233 2546 368090
SGTC_2989 9073649 71.4286 µM -0.0888670463608582 0.456314288471199 no 1828 0.464593786548204 2542 21367202
SGTC_542 3381-0244 89.3 µM -0.0896533907852583 0.456013656226474 no 1829 0.464281327741057 2660 1112843
SGTC_1883 5-benzylidenerhodanine 20 µM -0.089764260484874 0.455971270961148 no 1830 0.464237274749447 2617 1273210
SGTC_2263 7948595 193.29 µM -0.0903963152917735 0.455729647252031 no 1831 0.463986142339096 2567 2971371
SGTC_1416 3966-0321 25.3 µM -0.0908973245344077 0.455538131642312 no 1832 0.46378708805285 2599 582530 YLR208W SEC13
SGTC_2884 9058502 51.95 µM -0.0913595153241328 0.455361463920952 no 1833 0.463603464632087 2630 6471554
SGTC_2991 9074669 71.4286 µM -0.0917259237021462 0.455221414321867 no 1834 0.463457900039298 2651 17333109
SGTC_2836 9010338 19.48 µM -0.0918706528871598 0.455166097074402 no 1835 0.463400404215842 2589 2994051
SGTC_2092 5303694 80.6725 µM -0.0935526323389149 0.454523288187816 no 1836 0.462732269215461 2601 1963699
SGTC_1341 1486-1360 280 µM -0.0935754762410391 0.45451455865723 no 1837 0.462723195620283 2561 3976547
SGTC_75 0159-0059 199.013 µM -0.0938121217073366 0.454424128647522 no 1838 0.46262920121156 2637 5377270
SGTC_869 0564-0080 44.1 µM -0.0939309385228301 0.454378725728051 no 1839 0.462582008546672 2617 6843321
SGTC_35 0133-0054 64.071 µM -0.0962064274534139 0.453509319388697 no 1840 0.461678313063635 2601 99677
SGTC_1192 1488-0095 21.4 µM -0.0964030427710863 0.453434208081956 no 1841 0.461600237799852 2649 915875
SGTC_674 0498-0004 451 µM -0.0965601824639091 0.453374178515819 no 1842 0.461537839234252 2595 4231473
SGTC_2362 9071156 126 µM -0.0966116967306405 0.453354499575381 no 1843 0.461517383651549 2676 653133
SGTC_467 ro 31-8220 72.8 µM -0.0976472770055297 0.452958922409529 no 1844 0.461106191118691 2658 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2467 5474540 200 µM -0.097836014315133 0.452886832417173 no 1845 0.461031254632599 2576 5413519
SGTC_26 0302-0163 425.158 µM -0.0985388076916012 0.45261840754548 no 1846 0.460752228904116 2596 3100915
SGTC_89 0302-0250 142.109 µM -0.0987122691160147 0.45255215902346 no 1847 0.460683363550303 2562 4203518 YLR208W SEC13
SGTC_2943 9068529 45.32 µM -0.10038426019592 0.451913658886409 no 1848 0.460019632593642 2574 3270634
SGTC_1505 k297-0037 20.6 µM -0.100721140882123 0.45178502585237 no 1849 0.459885914358927 2602 4089396
SGTC_245 methotrexate 289.6 µM -0.100871232160209 0.451727717290493 no 1850 0.459826340006095 2641 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2852 9023854 51.95 µM -0.100886664727837 0.451721824811523 no 1851 0.459820214549847 2691 19798528
SGTC_1091 telmisartan 47.6 µM -0.101631350269949 0.451437500869513 no 1852 0.459524647182374 2686 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2602 kawain 100 µM -0.10255602430223 0.451084491281687 no 1853 0.459157673128039 2543 5369129
SGTC_852 0418-0143 439 µM -0.10272876783818 0.451018547863105 no 1854 0.459089120497571 2607 5369229
SGTC_2597 laccaic acid a 100 µM -0.103516108108558 0.450718004365244 no 1855 0.458776682874995 2671 5491415 A textile dye.
SGTC_2219 9098279 200 µM -0.103580941588312 0.450693257388593 no 1856 0.458750956352822 2594 902349
SGTC_719 2810-4230 27.3 µM -0.103895288022974 0.450573273892409 no 1857 0.458626223242494 2592 721079
SGTC_5 0352-0601 109.883 µM -0.104413025822122 0.45037566740572 no 1858 0.458420793036427 2575 762456
SGTC_1308 1187-1617 41.4 µM -0.106305665386647 0.449653403219457 no 1859 0.45766991836765 2572 2882570
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.107372280711156 0.449246437571297 no 1860 0.457246822071953 2568 2333 A French combination drug.
SGTC_562 3772-2733 112 µM -0.107544910536996 0.449180575900686 no 1861 0.457178349219124 2623 2876874 YIL048W NEO1
SGTC_3246 9135460 32.98 µM -0.107851984704328 0.449063424533749 no 1862 0.457056552759112 2595 41446951
SGTC_1941 st076221 61.8 µM -0.108600238663659 0.448777977994148 no 1863 0.456759785724343 2764 2828568
SGTC_333 3486-0131 40.1 µM -0.108618347820083 0.448771069977763 no 1864 0.456752603700845 2742 6744690
SGTC_699 0375-0592 111 µM -0.108823569280493 0.448692786179486 no 1865 0.456671214627299 2597 762578
SGTC_924 2046-0044 21.3 µM -0.109652584869706 0.448376570176665 no 1866 0.4563424526816 2601 3623589
SGTC_1429 4049-0205 9.46 µM -0.112858972262699 0.447153850604562 no 1867 0.455071181919569 2588 22774478
SGTC_2848 9016370 25.97 µM -0.112952131879476 0.447118332688508 no 1868 0.455034252741727 2609 7894410
SGTC_1247 0448-0043 5.84 µM -0.114060059245449 0.446695958315297 no 1869 0.454595091819903 2704 3089013 YGL099W LSG1
SGTC_3134 9127454 49.47 µM -0.114122481727406 0.446672162831004 no 1870 0.454570350405009 2583 24262820
SGTC_1132 3456-3614 2.5 µM -0.115333548725544 0.446210541530244 no 1871 0.454090373871391 2836 3125502
SGTC_1699 st031318 29.054 µM -0.116169034646362 0.445892122576574 no 1872 0.453759288668094 2706 5340658
SGTC_2163 5671233 125 µM -0.116747409434617 0.445671713801079 no 1873 0.453530109916106 2651 701023
SGTC_1010 4112-3296 15.2 µM -0.117208778751018 0.445495905851827 no 1874 0.453347305217313 2648 704384
SGTC_1691 st019933 84.6 µM -0.117516436353572 0.445378676761889 no 1875 0.453225409981051 2599 6176082
SGTC_1034 k072-0165 12.7 µM -0.118531484981389 0.444991939076838 no 1876 0.452823274762617 2687 5835461
SGTC_1435 4092-0789 56.7 µM -0.119404538601617 0.444659343935311 no 1877 0.452477432868856 2627 2248285
SGTC_335 4077-0256 27.6 µM -0.120685033891042 0.444171601925636 no 1878 0.451970256783829 2721 3121989
SGTC_1983 st071813 46.9 µM -0.120725158318752 0.444156319850879 no 1879 0.451954365640585 2677 11838595
SGTC_993 3909-8757 62.7 µM -0.120822329075897 0.444119311049641 no 1880 0.451915881811411 2669 4288324 YLR208W SEC13
SGTC_714 4296-0578 26.1 µM -0.121464513510297 0.44387473866089 no 1881 0.45166156033319 2654 1589775
SGTC_312 4092-0653 6.84 µM -0.12241609907925 0.443512371890236 no 1882 0.45128474458976 2721 1148278
SGTC_2130 NSC 7 2.4545 µM -0.122501781167262 0.44347974619558 no 1883 0.451250817725174 2697 21448
SGTC_2054 5233173 129 µM -0.125508031078822 0.4423352820748 no 1884 0.450060683716512 2731 6889
SGTC_1670 st016595 4.04 µM -0.125899405229133 0.442186323107255 no 1885 0.449905776744411 2620 597879
SGTC_872 0588-0139 234 µM -0.126313482972762 0.442028731937633 no 1886 0.44974189193738 2647 2047100
SGTC_1719 st032227 49.2 µM -0.126322887490767 0.442025152839426 no 1887 0.449738169891304 2663 3125804
SGTC_1840 st055363 71 µM -0.127426830919658 0.44160505561086 no 1888 0.449301290665621 2676 676033
SGTC_439 amiodarone 34.4 µM -0.127924581195218 0.441415662005819 no 1889 0.449104328942647 2703 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3130 9127414 49.47 µM -0.129430151463324 0.440842875363218 no 1890 0.44850864545637 2615 1494646
SGTC_2420 aureobasidin a 50 nM -0.129552720987771 0.440796249834365 no 1891 0.448460155540038 2931 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1278 0874-0585 172 µM -0.129739992380704 0.440725013256714 no 1892 0.448386070306104 2694 766306
SGTC_1502 4534-4282 27.7 µM -0.130222829285144 0.440541354716826 no 1893 0.448195066606345 2652 3278949
SGTC_1678 st019265 80.2 µM -0.133431349315856 0.439321244289069 no 1894 0.446926126949613 2705 5367020
SGTC_1895 st058434 18.3 µM -0.134079901489044 0.439074687672416 no 1895 0.446669696207078 2673 5393175
SGTC_2811 7967822 32.47 µM -0.134150422881176 0.439047879354418 no 1896 0.446641814128808 2744 2232244
SGTC_515 4092-1064 102 µM -0.134799700123909 0.43880107334619 no 1897 0.446385121470179 2757 717353
SGTC_3176 9106582 49.47 µM -0.134971479939616 0.438735779653402 no 1898 0.446317211835482 2639 17018027
SGTC_98 0074-0023 107.663 µM -0.135144555044664 0.43866999530589 no 1899 0.446248791727003 2718 3563821
SGTC_293 4049-0273 38.5 µM -0.138490965898674 0.437398388762569 no 1900 0.444926204493327 2676 1380311
SGTC_2307 7538926 6.34 µM -0.139169033960806 0.437140807221295 no 1901 0.444658288832362 2721 96582
SGTC_2938 9059746 27.26 µM -0.13968371452976 0.436945310389755 no 1902 0.444454947084042 2761 6471769
SGTC_1587 estradiol valerate 56.1 µM -0.141276055211235 0.436340571673308 no 1903 0.443825932524462 2679 13791 A steroid.
SGTC_3352 9151559 45.5865 µM -0.141493041351634 0.436258176221522 no 1904 0.443740228468494 2725 17159339
SGTC_1175 0741-0056 27.6 µM -0.142702732357475 0.435798874924091 no 1905 0.443262479348454 2817 765927
SGTC_1557 sumaresinolic acid 42.3 µM -0.143363355219554 0.43554808297046 no 1906 0.443001611136806 2652 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2369 9071472 200 µM -0.143832331658958 0.435370061385411 no 1907 0.442816435674799 2800 17296037
SGTC_2108 5365811 200 µM -0.145436561493694 0.43476120138757 no 1908 0.442183099814205 2756 780283
SGTC_1931 st074438 57.1 µM -0.145905987923206 0.434583067218398 no 1909 0.441997802250682 2617 2787313
SGTC_1694 st024011 44.9 µM -0.146112977480759 0.434504524701085 no 1910 0.441916100908826 2689 2787533
SGTC_1828 st055811 49 µM -0.147012952031381 0.434163058017277 no 1911 0.44156089857971 2768 5877589
SGTC_2391 6285546 200 µM -0.147283222457492 0.434060522089474 no 1912 0.441454237298204 2642 846083
SGTC_2589 lobaric acid 100 µM -0.147463986155452 0.433991945942602 no 1913 0.441382901903902 2714 73157 A novel microtubule depolymerizer.
SGTC_582 0987-0078 156 µM -0.147995432726224 0.433790343091594 no 1914 0.441173186353815 2679 1625765
SGTC_1234 0326-0494 15.5 µM -0.148886654434164 0.433452299178226 no 1915 0.440821536027855 2794 1547813
SGTC_2497 7-hydroxyflavone 100 µM -0.149435802538503 0.433244029355588 no 1916 0.440604881273089 2849 5281894
SGTC_1766 st045414 44.774 µM -0.150075423766005 0.433001470085473 no 1917 0.440352554681344 2668 253960
SGTC_1782 st039423 80.636 µM -0.150248352586536 0.432935895778709 no 1918 0.440284339493408 2711 2068169
SGTC_489 paxilline 115 µM -0.150497218939325 0.432841529333814 no 1919 0.440186172357594 2733 105008 A toxic potassium channel blocker.
SGTC_3240 9133527 49.47 µM -0.150808774691948 0.432723397393546 no 1920 0.440063282117077 2684 17617455
SGTC_2595 hexamethylquercetagetin 100 µM -0.151365396068454 0.43251235940912 no 1921 0.439843742423093 2768 386331
SGTC_2292 7671323 168.05 µM -0.151706122458905 0.432383185560194 no 1922 0.439709364023204 2810 937504
SGTC_3194 9111903 49.47 µM -0.151786487802048 0.432352719056087 no 1923 0.439677669907987 2837 17087251
SGTC_967 1306-0166 352 µM -0.15475819379514 0.431226429141527 no 1924 0.438505975282663 2745 4437607
SGTC_1340 1486-1359 257 µM -0.155339954885617 0.431006004217425 no 1925 0.438276659226186 2723 4309068
SGTC_102 gallobenzophenone 83.616 µM -0.156143245688546 0.430701678677869 no 1926 0.437960055628296 2832 70837
SGTC_1891 st059073 26.2 µM -0.157264152602225 0.430277093548524 no 1927 0.437518335374365 2856 688754
SGTC_2201 6605497 169.863 µM -0.157651680817422 0.430130321567672 no 1928 0.437365638671084 2729 670741
SGTC_2866 9034245 58.44 µM -0.158519877588713 0.429801536813019 no 1929 0.437023579319933 2795 6462273
SGTC_989 1501-0895 10.3 µM -0.158687360967067 0.429738116714408 no 1930 0.436957598240592 2701 2830112
SGTC_2690 usnic acid 100 µM -0.160197844400307 0.429166231562178 no 1931 0.436362613692625 2852 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1282 0886-0010 32.4 µM -0.162544872560948 0.428277916998899 no 1932 0.435438397443666 2802 2836211 YNL267W PIK1
SGTC_1495 4469-0029 237 µM -0.163226977327431 0.428019818625961 no 1933 0.435169863104538 2694 793680
SGTC_280 3448-3607 3.04 µM -0.164606169941671 0.427498046689507 no 1934 0.434626987278256 2731 626179
SGTC_454 lyso-paf C-16 6.67 µM -0.165964503638796 0.426984289948468 no 1935 0.434092442354261 2764 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3149 9097855 49.47 µM -0.167199539319752 0.426517275141797 no 1936 0.433606523443268 2834 25236625 YMR079W SEC14
SGTC_1904 st060225 78 µM -0.167332664145704 0.426466941629581 no 1937 0.433554152091452 2696 66595
SGTC_2821 7996764 71.43 µM -0.169802082377212 0.425533490854503 no 1938 0.432582894606328 2881 2987135
SGTC_1323 1348-1351 11.2 µM -0.170238252502942 0.425368659865613 no 1939 0.432411384808649 2722 6989654
SGTC_490 phenamil 164 µM -0.170926295464365 0.425108671332207 no 1940 0.432140860064024 2806 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1935 st074532 41.6 µM -0.17140938109899 0.424926148804387 no 1941 0.431950939447284 2843 2829742
SGTC_1665 st014639 11.4 µM -0.171643892316398 0.424837550064791 no 1942 0.431858749214193 2731 981133 YIL048W NEO1
SGTC_2751 anetholtrithion 17.25 µM -0.172441463185782 0.42453625486482 no 1943 0.431545238732251 2846 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2480 5767542 37.17 µM -0.17258835363787 0.424480769440887 no 1944 0.431487503485216 2760 2867358
SGTC_3097 9117246 49.47 µM -0.173191604079962 0.42425291732931 no 1945 0.431250411445958 2694 16423892
SGTC_1033 k072-0102 21.3 µM -0.173396663927351 0.424175470483851 no 1946 0.431169823594512 2828 5965931
SGTC_2081 5214970 32.255 µM -0.173612907231607 0.424093803050873 no 1947 0.431084843785099 2767 2063512
SGTC_3311 9131146 2.8755 µM -0.175733104424423 0.423293252882423 no 1948 0.430251813219787 2785 4900406 YPR165W RHO1
SGTC_1053 3366-3204 134 µM -0.177015783608865 0.422809088657428 no 1949 0.429747995915745 2765 3632071 YPR165W RHO1
SGTC_2305 7443522 69.23 µM -0.178160728428611 0.422377012537131 no 1950 0.429298375214136 2733 5415886
SGTC_517 1365-0151 113 µM -0.17818179078152 0.422369064957676 no 1951 0.429290104869407 2880 768657
SGTC_577 r071-0003 38.6 µM -0.178845323966221 0.422118706341394 no 1952 0.429029577799471 2732 4568517 YMR134W ERG29
SGTC_2005 4024620 188 µM -0.179174192068908 0.421994632323134 no 1953 0.428900463767534 2720 236743
SGTC_966 1300-0360 30.2 µM -0.179896600471843 0.421722112221462 no 1954 0.428616872046877 2737 70588
SGTC_3348 9149464 3.537 µM -0.180965082267395 0.421319108746198 no 1955 0.428197491886009 2694 1951442
SGTC_1510 1123-0200 71.5 µM -0.181000424537067 0.421305779969305 no 1956 0.428183621393024 2932 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2915 7971052 15.16 µM -0.181108658613881 0.421264961763584 no 1957 0.428141144197651 2711 5741558
SGTC_2699 st077704 54.6 µM -0.181574516279141 0.42108928300751 no 1958 0.427958324717175 2784 645852
SGTC_838 0109-0203 71.4 µM -0.182975930826626 0.420560892911979 no 1959 0.427408452094821 2731 759422
SGTC_1366 1683-0113 21.9 µM -0.183722462073213 0.420279478727146 no 1960 0.427115593332193 2722 708623
SGTC_708 3448-5400 146 µM -0.18506651731533 0.419772923295894 no 1961 0.426588431621346 2762 3462195
SGTC_1494 4358-1428 177 µM -0.186171489945555 0.419356574223687 no 1962 0.426155140405854 2857 1564571
SGTC_3220 9131269 49.47 µM -0.187291544944229 0.418934634309517 no 1963 0.425716025924968 2684 17722206
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.190766477690676 0.417626175375295 no 1964 0.424354276624786 2782 2374 Ca(2+)-ATPase inhibitor.
SGTC_2705 st078069 42.8 µM -0.191057469018168 0.417516646011666 no 1965 0.424240284286638 2823 1530061
SGTC_413 propylparaben 100 µM -0.191449952548319 0.417368925041354 no 1966 0.424086543643898 2728 7175 A pharmaceutical preservative.
SGTC_718 1130-0073 349 µM -0.192359885404721 0.417026493998569 no 1967 0.423730156188379 2899 6740020
SGTC_825 1988-2224 89.6 µM -0.192854301800833 0.416840458815472 no 1968 0.42353653748472 2740 1180859
SGTC_2157 5649910 96.377 µM -0.193208431559189 0.416707221047682 no 1969 0.423397867860136 2771 2858091
SGTC_2544 sphondin 68.51 µM -0.194467330952834 0.416233650348339 no 1970 0.422904986763206 2982 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2693 st077581 40.7 µM -0.194685647960349 0.416151536567651 no 1971 0.4228195240969 2816 25238761
SGTC_1786 berberine 21.6 µM -0.195160158904684 0.415973075294975 no 1972 0.422633783943656 2749 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2809 7964133 12.99 µM -0.195486007146081 0.415850535377622 no 1973 0.422506245522072 2805 1253665
SGTC_2091 4-phenylthiadiazole 200 µM -0.197018432219072 0.41527435479302 no 1974 0.421906556826143 2778 270010
SGTC_276 colchicine 750 µM -0.198402952612579 0.414753941875232 no 1975 0.421364903756559 2870 2833 A microtubule depolymerizer.
SGTC_1075 aripiprazole 15.2 µM -0.198427010113688 0.41474490047175 no 1976 0.421355493275648 2749 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1012 4112-3522 18 µM -0.198619801681486 0.414672446267425 no 1977 0.421280081356629 2897 3112398
SGTC_337 1315-0038 354 µM -0.198989143915425 0.414533649563001 no 1978 0.421135618340711 2770 1626437
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.199155417390572 0.414471168421783 no 1979 0.421070586275923 2907 551469
SGTC_538 2922-0838 53.3 µM -0.200168456409036 0.414090542167941 no 1980 0.420674418022873 2859 777039
SGTC_1664 st014217 9.02 µM -0.200892463257037 0.41381856255887 no 1981 0.420391330515245 2779 3982782
SGTC_2655 perillic acid 100 µM -0.203736526055612 0.412750566379914 no 1982 0.419279698567321 2763 5702197 An apoptosis inducer.
SGTC_1961 st076550 68.7 µM -0.20397801022329 0.412659914401431 no 1983 0.419185341470761 2895 1579337
SGTC_2867 9039098 71.43 µM -0.204022256232044 0.412643305170399 no 1984 0.419168053367205 2744 6463460
SGTC_656 4090-1979 187 µM -0.205536666402837 0.412074914744129 no 1985 0.418576426953778 2880 22330961
SGTC_2917 7979103 53.79 µM -0.205899613603033 0.411938720268741 no 1986 0.41843466364112 2925 2980565
SGTC_791 1348-1292 225 µM -0.206980306138943 0.411533257617402 no 1987 0.418012619443074 2838 5437054
SGTC_71 0417-1750 47.813 µM -0.207368410236439 0.411387668725958 no 1988 0.41786107567982 2988 6811472
SGTC_1430 4049-0248 69.1 µM -0.208151328543285 0.411094010942276 no 1989 0.417555405181866 2888 22774488
SGTC_930 2810-3379 265 µM -0.209049546393644 0.410757167855099 no 1990 0.417204780279675 2985 1015764
SGTC_124 0136-0217 7.121 µM -0.209754939633267 0.410492682560788 no 1991 0.416929471795035 2885 3976905
SGTC_1376 2910-0861 41.3 µM -0.209893258162051 0.410440825170258 no 1992 0.416875492119605 2775 1112859
SGTC_3239 9133757 49.47 µM -0.213115347542255 0.409233267437518 no 1993 0.415618497004467 2768 17036923
SGTC_1815 st051655 58.2 µM -0.213391818963047 0.409129692868667 no 1994 0.415510680540542 2856 5984156
SGTC_1168 k815-0004 80.5 µM -0.214262367651991 0.408803600429603 no 1995 0.415171231405188 2776 642433
SGTC_773 4358-1457 44.6 µM -0.214416002744378 0.408746057934909 no 1996 0.415111331729949 2916 1186886
SGTC_3079 9117512 49.47 µM -0.215394096831545 0.408379768702234 no 1997 0.414730036023076 2738 7185044
SGTC_3310 9130229 44.1445 µM -0.216086306143983 0.408120589613939 no 1998 0.414460236840239 2957 7761258
SGTC_559 1550-0661 158 µM -0.21667419627731 0.407900501585081 no 1999 0.414231129339518 2866 5830875
SGTC_248 streptozotocin 5.23457 mM -0.217258062299932 0.407681948820258 no 2000 0.414003618963591 2872 5300 DNA alkylating agent.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.217717534783393 0.407509979247953 no 2001 0.413824600304076 2805 77254
SGTC_2129 girgensonine 121.053 µM -0.218369274166182 0.407266079346186 no 2002 0.413570701761337 2862 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_652 0437-0092 114 µM -0.218644735649457 0.407163004421146 no 2003 0.413463400906072 2796 3091274
SGTC_3190 9110366 49.47 µM -0.219666359884698 0.406780779066187 no 2004 0.413065502832632 2879 17123768
SGTC_2033 5192550 145 µM -0.220263970347882 0.406557233225069 no 2005 0.412832789291952 2831 182073
SGTC_322 k048-0136 19.3 µM -0.220753916317661 0.406373983736952 no 2006 0.412642023876948 2886 6823282
SGTC_2601 securinine 100 µM -0.221560897361103 0.406072201574634 no 2007 0.412327862648815 2807 442872 A GABA receptor antagonist.
SGTC_2417 cerulenin 830 nM -0.221671556047241 0.40603082351457 no 2008 0.412284787115871 2782 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1725 st036284 20.55 µM -0.221944077025876 0.405928925557412 no 2009 0.412178708793977 3038 707914
SGTC_3070 9117005 49.47 µM -0.222903181406399 0.405570358837453 no 2010 0.411805430138259 2794 8779016
SGTC_2287 7945887 168.79 µM -0.223105476552762 0.405494739734283 no 2011 0.411726708052256 2905 1245853
SGTC_769 0302-0231 76 µM -0.223999499934374 0.405160590865893 no 2012 0.411378846171567 2889 571869 YER009W NTF2
SGTC_2831 7999036 19.48 µM -0.224503728307523 0.40497216167981 no 2013 0.411182683092314 3091 2988270
SGTC_493 zm226600 134 µM -0.22460667969925 0.404933691646884 no 2014 0.411142634004447 2989 5240098 A potassium channel opener. YCR052W RSC6
SGTC_7 0192-1582 4.227 µM -0.224868445286979 0.404835881364354 no 2015 0.411040808828849 2832 252616
SGTC_90 0870-0863 4.608 µM -0.225320090562702 0.404667135378782 no 2016 0.410865135738351 2789 1738164
SGTC_426 0988-0037 14.6 µM -0.225473748844007 0.404609728837228 no 2017 0.410805372497858 2892 5383008
SGTC_2326 6164455 177.58 µM -0.226015484035794 0.404407353636163 no 2018 0.410594688694911 2883 2888790
SGTC_1041 0206-0046 107 µM -0.226282251815766 0.404307706991879 no 2019 0.41049095070933 2888 50494
SGTC_2195 6536160 144.242 µM -0.227131992166802 0.403990342098755 no 2020 0.410160553956988 2799 3834386
SGTC_1264 0783-0040 158 µM -0.227222870980633 0.40395640400239 no 2021 0.41012522215104 2765 2855798
SGTC_2994 9053520 71.4286 µM -0.227648929091406 0.40379730504186 no 2022 0.409959589289331 2952 4647384
SGTC_1583 clindamycin 39.6 µM -0.227764385393355 0.403754193996946 no 2023 0.409914707666241 2799 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3052 9092717 49.47 µM -0.227942910621479 0.403687535501653 no 2024 0.40984531142201 2986 25237534
SGTC_1391 3442-0225 151 µM -0.228202268939148 0.403590700194294 no 2025 0.40974449880843 2816 5227075
SGTC_1350 1495-0454 146 µM -0.228658864834591 0.403420237650572 no 2026 0.409567034423362 2976 1069057
SGTC_602 3130-1533 38.1 µM -0.23002963310647 0.402908594279336 no 2027 0.409034371588296 2933 720941
SGTC_1051 3253-3903 78 µM -0.231949652609109 0.402192220861166 no 2028 0.408288559380431 2772 5509239
SGTC_2980 9014342 25.29 µM -0.231958115931971 0.402189063858305 no 2029 0.408285272621229 2988 2996599
SGTC_2011 4012611 177 µM -0.23361498163344 0.401571140183116 no 2030 0.40764194794603 2817 2049887
SGTC_497 capsazepine 133 µM -0.233874807647515 0.401474261036917 no 2031 0.407541085733138 2825 2733484 A calcium channel blocker.
SGTC_1343 1487-0095 224 µM -0.233905766560174 0.401462718050526 no 2032 0.40752906815935 2876 4560101 YGL055W OLE1
SGTC_3111 9122088 49.47 µM -0.23487116656294 0.401102813233116 no 2033 0.407154364684456 2870 16876704
SGTC_1822 st052468 42 µM -0.235145420232925 0.401000585705774 no 2034 0.407047933300457 2867 2873678
SGTC_135 0933-0004 26.348 µM -0.235685924562315 0.400799133606827 no 2035 0.406838196412031 2936 21230617 YGL099W LSG1
SGTC_2443 5493264 126.67 µM -0.237463669302971 0.400136734294831 no 2036 0.406148550451284 3003 5340055
SGTC_605 1315-0399 119 µM -0.240633299960557 0.398956422834636 no 2037 0.40491966938591 2966 24020461
SGTC_1985 st071382 65.5 µM -0.241122444730085 0.398774356398306 no 2038 0.404730108763493 2853 6123237
SGTC_2970 9090938 41.86 µM -0.243157251653414 0.398017209975031 no 2039 0.403941790680716 3077 17217104
SGTC_1062 mesoridazine 14.2 µM -0.243780475947424 0.397785386480933 no 2040 0.40370042107696 2816 4078 A neuroleptic.
SGTC_1244 0416-0015 52.5 µM -0.243895966757963 0.397742430814876 no 2041 0.403655696467759 2860 96201
SGTC_1235 benzylparaben 21.5 µM -0.244316469124816 0.397586039591887 no 2042 0.403492864687474 2930 7180
SGTC_2067 5224629 34.075 µM -0.245575182439737 0.397118003442179 no 2043 0.403005551274035 2986 2835000
SGTC_2321 7390090 138.78 µM -0.245619376525336 0.397101573134963 no 2044 0.402988444176721 2920 649046
SGTC_705 1124-0212 310 µM -0.245663148973399 0.397085299762547 no 2045 0.40297150047421 2954 9554485
SGTC_1486 3970-0793 4.53 µM -0.245757740702571 0.397050133814216 no 2046 0.40293488596099 2952 2844330
SGTC_297 0986-0032 24 µM -0.24636530434715 0.396824282533828 no 2047 0.402699730871822 2816 2847425
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.246561410434199 0.396751390870249 no 2048 0.402623836301447 2828 66535 A nucleotide analog.
SGTC_864 0469-0573 172 µM -0.246564082586629 0.396750397669302 no 2049 0.402622802183153 2826 689425
SGTC_372 0155-0182 15.9 µM -0.24773514041596 0.3963151967316 no 2050 0.402169670536099 2838 771486
SGTC_1573 oleylamine 1.06 µM -0.248023826433877 0.396207931995097 no 2051 0.402057985916955 2818 5356789 An amine of the fatty acid oleic acid.
SGTC_1636 st007707 68.9 µM -0.249011356281261 0.395841062946186 no 2052 0.401675998505567 3018 403051
SGTC_857 0438-0306 1.35 µM -0.250147756952694 0.395419002305334 no 2053 0.401236542469852 2946 4686136
SGTC_1726 st035556 14.5795 µM -0.250152474763829 0.39541725035962 no 2054 0.401234718311185 3057 5919439
SGTC_1784 st039334 36.3 µM -0.250311358293449 0.39535825064826 no 2055 0.401173286679565 3084 3496984
SGTC_1369 1866-0067 208 µM -0.250867113407849 0.395151895764721 no 2056 0.400958425589269 2972 3531355
SGTC_1246 0422-0085 105 µM -0.250941898343113 0.395124129956396 no 2057 0.400929515189166 2982 264295
SGTC_808 0711-0032 135 µM -0.251842981621921 0.394789621784074 no 2058 0.400581216630799 2857 4252555
SGTC_221 trifluoperazine 10.304 µM -0.252053036638484 0.394711654423704 no 2059 0.400500034752755 2864 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3144 9087057 49.47 µM -0.252137847780624 0.394680175766305 no 2060 0.400467258234968 2865 17249618
SGTC_1417 3966-0327 90.4 µM -0.25270291093187 0.394470463463832 no 2061 0.400248899141055 2895 651118
SGTC_1407 3909-7909 12.3 µM -0.253039117409131 0.394345701414203 no 2062 0.400118992626317 2858 4411780
SGTC_268 camptothecin 39.6153 µM -0.253173870348973 0.394295699313142 no 2063 0.400066928662085 2877 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_216 k038-0035 28.382 µM -0.254185456131469 0.393920390898734 no 2064 0.399676143011534 2930 4444231 YPR107C YTH1
SGTC_3080 9117754 49.47 µM -0.254953256169693 0.393635595159848 no 2065 0.399379601267566 3068 9550191
SGTC_2711 st079103 59.1 µM -0.255179013354198 0.393551867136261 no 2066 0.399292419770821 2909 54693780
SGTC_2412 st077135 33.4 µM -0.2557942080766 0.393323730891381 no 2067 0.399054873224825 3132 13258915
SGTC_1085 doxorubicin 7.67 µM -0.258485064632258 0.392326296276624 no 2068 0.398016287036625 2955 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_158 k038-0087 26.446 µM -0.259123726194623 0.392089663644138 no 2069 0.397769889490894 2836 X158
SGTC_882 0843-0131 351 µM -0.260583088428852 0.391549100358197 no 2070 0.397207016347153 2852 5425421
SGTC_3175 9106517 49.47 µM -0.262942145463954 0.39067572369067 no 2071 0.396297585761359 2954 41468073
SGTC_146 3448-8650 53.125 µM -0.264394096401522 0.390138452127054 no 2072 0.395738130058817 2903 2891488 YIL048W NEO1
SGTC_3329 9141233 27.5565 µM -0.264476469535145 0.39010797752592 no 2073 0.39570639703839 3039 4909101 YNL103W MET4
SGTC_1071 trifluoperazine 6.31 µM -0.267021472692216 0.389166766839427 no 2074 0.394726314170034 3026 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3039 9090270 49.47 µM -0.267220806160366 0.389093075332507 no 2075 0.394649578722845 2987 17173750
SGTC_1351 1496-0003 46.5 µM -0.267356144409675 0.389043044465011 no 2076 0.394597481215873 3007 3891978
SGTC_237 nikkomycin 200 µM -0.267871664653674 0.388852487518338 no 2077 0.394399052597781 3021 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_403 arphamenine a 50 µM -0.270033960434947 0.388053508089245 no 2078 0.393567063550568 2880 5487158 An arginine aminopeptidase inhibitor.
SGTC_2188 6126565 140.678 µM -0.270273519720217 0.387965018781201 no 2079 0.393474917864681 2993 874518
SGTC_731 3966-0296 387 µM -0.271004788518286 0.38769493596696 no 2080 0.393193674664736 2887 660956
SGTC_2425 5628681 7.85 µM -0.271276249650734 0.387594689819121 no 2081 0.393089285921737 2962 5714958
SGTC_2563 tomatine 8.54 µM -0.271320738815628 0.38757826141402 no 2082 0.39307217861436 3007 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2584 androsterone 48.74 µM -0.271537545602579 0.387498204583157 no 2083 0.392988813398231 3020 2754130 A steroid.
SGTC_3170 9103054 49.47 µM -0.272386445824223 0.387184790616728 no 2084 0.392662446752262 2942 16432970
SGTC_2465 5809242 33.21 µM -0.273907795189843 0.386623292509378 no 2085 0.392077740456049 2867 2731748
SGTC_3281 9140613 49.47 µM -0.274976742604082 0.386228908315859 no 2086 0.391667053253016 2930 16013766
SGTC_76 0433-0009 400.328 µM -0.276600401567931 0.385630090288532 no 2087 0.391043478158532 3008 2841569
SGTC_523 1934-0222 13.7 µM -0.277446191374606 0.385318264293986 no 2088 0.390718758779844 2896 1361595
SGTC_3113 9123498 49.47 µM -0.278626332455701 0.384883293503001 no 2089 0.390265801143845 2887 8897275
SGTC_1689 st020265 53.493 µM -0.278915674250652 0.384776671366975 no 2090 0.390154769693434 3027 5758320 YPR016C TIF6
SGTC_1056 3448-1962 115 µM -0.279347767924982 0.384617461543772 no 2091 0.389988975602188 2987 715507
SGTC_300 r073-0011 5.04 µM -0.284407569318353 0.382754574911454 no 2092 0.388049029467639 2975 2735780
SGTC_2118 5526350 200 µM -0.285651202015426 0.382297114976738 no 2093 0.38757264153714 3012 743594
SGTC_3267 9137951 49.47 µM -0.285865603655413 0.38221826569836 no 2094 0.387490529582958 2856 16643986
SGTC_854 0422-0053 192 µM -0.285901831586536 0.382204942839335 no 2095 0.387476655436849 2926 3596728
SGTC_2324 6149169 200 µM -0.286361672439271 0.382035848016411 no 2096 0.38730056350015 2980 2888231
SGTC_2026 5148700 152 µM -0.286530749643226 0.381973679814149 no 2097 0.387235822727148 2896 79838
SGTC_2531 methyl deoxycholate 70.07 µM -0.290659210406476 0.380456629097465 no 2098 0.385655985334848 2907 16667744 Haematoxylin.
SGTC_558 k064-0027 21.3 µM -0.290678616612662 0.380449502381349 no 2099 0.385648563619722 3023 5088526
SGTC_733 4069-0007 56.1 µM -0.291279709595639 0.380228777688503 no 2100 0.385418702188901 2941 5717425 YNL287W SEC21
SGTC_803 4488-1585 147 µM -0.291575292128486 0.380120252434236 no 2101 0.385305684475051 3046 747204
SGTC_2117 5521686 200 µM -0.292798709453833 0.379671166419747 no 2102 0.384838007376986 2880 803312
SGTC_514 4466-0038 2.65 nM -0.293680212749921 0.379347689061094 no 2103 0.384501137919957 2961 5722064
SGTC_2652 actinonin 100 µM -0.293787227164822 0.379308424684839 no 2104 0.384460247931121 2908 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1064 honokiol 6.76 µM -0.294646806356992 0.378993083946468 no 2105 0.384131851151828 3003 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1940 st075990 51.1 µM -0.295584887563594 0.378649036257471 no 2106 0.383773558085973 3183 1084979
SGTC_2248 tofa 1.1 µM -0.296036302029386 0.378483511169882 no 2107 0.383601179107631 2875 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2880 9042983 58.44 µM -0.296408821327149 0.378346932225771 no 2108 0.383458944707611 3067 6464714
SGTC_2013 4024628 200 µM -0.296647131776368 0.378259567032103 no 2109 0.383367961834945 3082 5230760
SGTC_1698 5-fluorocytosine 1.055 µM -0.297385778145202 0.377988817025669 no 2110 0.383086000108862 3064 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2616 abietic acid 100 µM -0.297828137872185 0.377826699236378 no 2111 0.382917168820655 3078 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2588 indole-3-carbinol 100 µM -0.298335063764156 0.377640945433661 no 2112 0.382723722519627 3074 3712 Induces cell cycle arrest.
SGTC_230 MPP+ 141.667 µM -0.298573588814958 0.377553552039779 no 2113 0.382632709887468 2976 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3105 9121040 49.47 µM -0.298850587716159 0.377452070046688 no 2114 0.382527025143679 2890 41448907
SGTC_1750 st081859 2.357 µM -0.298977186516765 0.377405691817933 no 2115 0.382478726197315 2956 5291695
SGTC_1418 3966-3099 2.4 µM -0.299728088837517 0.377130642480599 no 2116 0.382192285643868 3027 740335
SGTC_2984 9022109 38.96 µM -0.299997814885545 0.377031859257985 no 2117 0.382089411187349 3040 6459207
SGTC_1123 mangostin 811.285 nM -0.303061818137609 0.37591027927154 no 2118 0.380921375650506 3004 5281650 An antioxidant.
SGTC_2671 danthron 100 µM -0.304920018552812 0.375230593656964 no 2119 0.380213534378376 2992 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1111 tnp00062 510.699 nM -0.305013322635902 0.375196475429368 no 2120 0.380178002758481 3089 676306
SGTC_720 r052-1644 49.9 µM -0.306521949781763 0.374644955908275 no 2121 0.379603635049909 3067 1422863 YOR257W CDC31
SGTC_2815 7968870 71.43 µM -0.30841078156622 0.373954803744663 no 2122 0.378884889527306 2941 2977326 YHR190W ERG9
SGTC_604 1000-0114 314 µM -0.308438812569781 0.373944564652101 no 2123 0.37887422620846 3092 1572745
SGTC_1007 4101-0031 70 µM -0.308851299824531 0.373793902661527 no 2124 0.378717321937112 3101 1146276
SGTC_1150 3909-7983 10.9 µM -0.308935587978463 0.373763118576608 no 2125 0.378685262383644 2983 23965914
SGTC_677 0929-0063 136 µM -0.309122697488312 0.373694784508709 no 2126 0.378614097035288 2982 1539583
SGTC_3255 9139072 49.47 µM -0.30995811457766 0.373389731175994 no 2127 0.378296404222825 3023 17646060
SGTC_314 1671-0008 2.74 µM -0.310819827371323 0.373075159055758 no 2128 0.377968797847881 2935 3913060
SGTC_1955 wogonin 32.4 µM -0.312942598717996 0.372300593133168 no 2129 0.377162136364625 3179 5281703 A flavanone.
SGTC_156 3474-0145 5.642 µM -0.31365213530561 0.372041809352337 no 2130 0.376892628953037 2939 2265471
SGTC_2824 7998404 51.95 µM -0.313948742215306 0.371933647333823 no 2131 0.376779984792131 2938 837851
SGTC_861 0443-0273 110 µM -0.314785736672799 0.371628479668022 no 2132 0.376462171045597 3052 6149169
SGTC_2644 guaiazulene 100 µM -0.316003549774933 0.37118460984968 no 2133 0.375999906881871 3040 3515 A coloring agent.
SGTC_3137 9097352 49.47 µM -0.316063112985944 0.37116290457622 no 2134 0.375977302109475 3260 44120435
SGTC_659 k018-0002 107 µM -0.316171791314821 0.371123302447581 no 2135 0.375936058806294 3090 6797879 YHR007C ERG11
SGTC_2349 9023730 187.07 µM -0.316316705385343 0.37107049822266 no 2136 0.375881066284788 3115 4126287
SGTC_82 0054-0107 293.755 µM -0.316441520446457 0.371025019680928 no 2137 0.375833703029399 3022 3104697
SGTC_2339 9000433 200 µM -0.317116138501971 0.370779242035129 no 2138 0.375577739819358 3013 2988954
SGTC_1980 st071811 45.7 µM -0.319245734758674 0.370003731310576 no 2139 0.37477008930547 3110 4974850
SGTC_1304 1165-0502 251 µM -0.319477119456638 0.369919502352098 no 2140 0.374682369536596 2985 767425
SGTC_1739 st037196 92.5 µM -0.319983604915548 0.369735152639227 no 2141 0.374490379530467 3158 612214
SGTC_3287 9117173 37.0625 µM -0.320020636854938 0.369721674991039 no 2142 0.374476343304523 3031 2789709
SGTC_3195 9113082 49.47 µM -0.321733558249417 0.369098438250361 no 2143 0.373827276328036 3066 17018038
SGTC_1096 rimcazole 32.2 µM -0.321754257865595 0.369090908912536 no 2144 0.373819434930673 2949 18528119 A dopamine reuptake inhibitor.
SGTC_161 4065-0411 162.148 µM -0.322891562523901 0.368677299717855 no 2145 0.373388683241703 3092 1906281 YLR208W SEC13
SGTC_3337 9144342 33.5465 µM -0.323338122232002 0.36851493869902 no 2146 0.37321959292766 3060 17682949
SGTC_583 1488-1091 88.9 µM -0.323382476538886 0.368498813557664 no 2147 0.373202799453965 3057 4303273
SGTC_997 3996-0078 137 µM -0.323760037985335 0.368361559339499 no 2148 0.373059856502522 3038 735687
SGTC_284 0988-0104 32.6 µM -0.326268744736221 0.367450001144052 no 2149 0.372110516778486 3055 4666532
SGTC_1302 1159-0335 255 µM -0.328085163970978 0.366790456546968 no 2150 0.37142363557748 2995 649284
SGTC_1653 st012112 65 µM -0.330713244478466 0.365836892672709 no 2151 0.370430548545196 3154 720429
SGTC_3312 9133330 71.43 µM -0.330831884489521 0.365793865227048 no 2152 0.370385737707968 3134 17617324
SGTC_2718 lomofungin 53.02 µM -0.330911492636802 0.365764994503613 no 2153 0.370355670357836 3141 5351222 A RNA synthesis inhibitor.
SGTC_901 1112-0062 60.1 µM -0.333603319251392 0.364789223998679 no 2154 0.369339456610403 2993 1908457
SGTC_206 4546-0025 72.014 µM -0.334271473687159 0.364547157477534 no 2155 0.369087357149448 3075 6620745 YIL048W NEO1
SGTC_2683 piperine 63.03 µM -0.334495730380394 0.364465923334169 no 2156 0.369002756104686 3005 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_11 0438-0307 1.3 µM -0.335200485305707 0.364210674434754 no 2157 0.36873692798337 3094 4011476
SGTC_1927 st060202 13.8 µM -0.335271264916148 0.364185042724792 no 2158 0.368710233928094 3044 688887
SGTC_1001 4048-4355 44.4 µM -0.335685448921916 0.364035064757435 no 2159 0.368554039911608 2983 21824233
SGTC_1093 fluphenazine 7.97 µM -0.335942412677506 0.363942027443916 no 2160 0.368457146549658 2997 6602611 An atypical antipsychotic.
SGTC_1126 isoteolin 1.0172 µM -0.338494014601347 0.36301862036776 no 2161 0.367495468419252 2982 133323
SGTC_1420 4'-methoxyflavone 42 µM -0.339781562655721 0.362552967376889 no 2162 0.367010516795339 3097 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2103 5378138 10 µM -0.339928965091897 0.362499670952273 no 2163 0.366955011569639 3028 244142
SGTC_634 1611-4317 11.2 µM -0.340249556462678 0.362383763657639 no 2164 0.366834300669185 3088 2843522
SGTC_2128 5255449 168.493 µM -0.340496651082967 0.362294437143534 no 2165 0.366741272170747 3001 736008
SGTC_1861 st057647 17.4 µM -0.342878639777236 0.361433715961249 no 2166 0.365844880869259 3193 688668
SGTC_1084 voriconazole 435 nM -0.343180775547702 0.361324590518547 no 2167 0.365731233175149 3126 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2743 auranofin 4.32 µM -0.343786842875242 0.361105725052355 no 2168 0.365503297839957 3033 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_764 1951-2361 146 µM -0.345496765973113 0.360488476040007 no 2169 0.364860470574774 3018 5438930
SGTC_907 3448-6986 75.5 µM -0.345675396495063 0.360424014828345 no 2170 0.364793338217978 3193 590582
SGTC_1658 st012944 20 µM -0.347068193594889 0.359921541554037 no 2171 0.364270043933286 3086 24207260
SGTC_1851 st056236 18.9 µM -0.347896523576568 0.359622823282415 no 2172 0.363958948087506 3189 5393171
SGTC_2800 7887935 81.82 µM -0.348216653361231 0.359507398757614 no 2173 0.363838740966984 3173 2961002
SGTC_199 4063-0024 41.6 µM -0.34858565938616 0.359374367542037 no 2174 0.363700197689371 3131 306215
SGTC_469 w7 172 µM -0.35025115093606 0.358774149609052 no 2175 0.363075111002942 3051 45115570 A P450 inhibitor.
SGTC_2276 7947513 42.08 µM -0.351415527770181 0.358354732769072 no 2176 0.362638317426747 3096 2105100
SGTC_1456 k015-0012 13 µM -0.352745523000804 0.357875868019925 no 2177 0.36213961394745 3227 2989616
SGTC_3118 9124250 49.47 µM -0.35442150498532 0.35727274918142 no 2178 0.361511510269201 3056 1504786
SGTC_1619 st003326 88.7 µM -0.354540082403159 0.357230091396702 no 2179 0.361467085409671 3171 2849032
SGTC_1876 myriocin 605 nM -0.355822471789916 0.356768870682271 no 2180 0.360986759495043 3220 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_974 1326-0144 138 µM -0.35614906349337 0.356651443004483 no 2181 0.360864467778841 3060 5411856
SGTC_1620 st003704 16.5 µM -0.357363169530114 0.35621502431968 no 2182 0.360409972619706 3164 2834414
SGTC_488 nitrendipine 139 µM -0.357408082086383 0.356198883803136 no 2183 0.360393163583197 3037 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1830 st055982 50.3 µM -0.357671312730229 0.356104290081058 no 2184 0.360294651937923 3154 455313 An antimicrobial agent.
SGTC_1198 1612-1005 86.7 µM -0.357922501825593 0.356014031828538 no 2185 0.360200655378985 3214 6998509
SGTC_2214 7179297 48.276 µM -0.358354629574687 0.355858776870634 no 2186 0.360038970200159 3055 769744
SGTC_2745 rifampicin 24.3 µM -0.358551256483237 0.355788140620415 no 2187 0.35996540844372 3074 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_796 1234-0020 70.7 µM -0.358884476397429 0.355668446005074 no 2188 0.35984075656474 3030 46495034
SGTC_1060 3448-7350 82 µM -0.359954711522581 0.355284107352822 no 2189 0.359440500762055 3163 570178
SGTC_1206 3978-0017 132 µM -0.360656762023046 0.355032069620279 no 2190 0.359178025542371 3280 3873677
SGTC_1971 st069429 63.5 µM -0.361587378536739 0.354698073930071 no 2191 0.358830198919649 3166 1246522 YGL099W LSG1
SGTC_763 3453-1109 128 µM -0.362021274700901 0.354542387951784 no 2192 0.358668066156212 3200 1560353
SGTC_641 4092-0595 30 µM -0.363438943143087 0.354033884837879 no 2193 0.358138507631537 3124 786260
SGTC_1330 1469-0054 61.8 µM -0.364067573066031 0.353808484959696 no 2194 0.357903775273797 3177 7102664
SGTC_556 4058-0063 51.5 µM -0.364727995534677 0.353571740816251 no 2195 0.357657229341835 3096 6615692
SGTC_645 0845-0943 5.41 µM -0.366862333549099 0.352807024229795 no 2196 0.356860854433555 3099 1885106
SGTC_2170 morpholine 200 µM -0.368641987399262 0.352169842387073 no 2197 0.356197297482035 3160 121171 Reacts with secondary amines.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.368740433627227 0.352134607090633 no 2198 0.35616060377198 3185 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2736 butenafine 14.65 µM -0.369001357437813 0.352041224912441 no 2199 0.356063356488689 3059 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_411 enrofloxacin 100 µM -0.369342864944619 0.351919016069022 no 2200 0.355936089506812 3220 71188 A bacterial gyrase inhibitor.
SGTC_2623 humulene 100 µM -0.370107377350305 0.351645489914303 no 2201 0.355651242742784 3120 6187145 An anti-inflammatory.
SGTC_1868 st057644 42.7 µM -0.370315119349515 0.351571177540412 no 2202 0.355573854860987 3013 688665
SGTC_2985 9022375 71.43 µM -0.372072120105359 0.350942899582617 no 2203 0.354919576739936 3240 4939335
SGTC_1641 st009299 47.1 µM -0.372257179680906 0.350876748645663 no 2204 0.354850688463827 3140 4046054
SGTC_1988 st071872 53.4 µM -0.372324964839431 0.350852519461894 no 2205 0.354825456681191 3188 16414116
SGTC_332 4112-0506 40.9 µM -0.373983490713173 0.350259883764071 no 2206 0.354208299471571 3064 2790355
SGTC_1458 k015-0034 6.33 µM -0.374243570483197 0.350166983316197 no 2207 0.354111555367596 3106 3598957
SGTC_1847 st056231 15 µM -0.374405062803386 0.350109302799386 no 2208 0.354051488421566 3049 5393180
SGTC_2490 carminic acid 95.39 µM -0.37485489071992 0.349948655147027 no 2209 0.353884194420212 3057 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3108 9121785 49.47 µM -0.375196670252473 0.349826612911994 no 2210 0.353757103189309 3075 17140271
SGTC_2029 5175081 200 µM -0.376034622020865 0.349527463744643 no 2211 0.353445578551851 3053 1380876
SGTC_1773 st048542 73.5835 µM -0.376721203741577 0.349282423377685 no 2212 0.353190401776655 3045 3237138
SGTC_2967 9089538 49.85 µM -0.379271679293012 0.348372711805986 no 2213 0.352243064018205 3273 728216
SGTC_2653 dihydrofissinolide 100 µM -0.379666672532625 0.348231902194464 no 2214 0.352096431191685 3159 6857746
SGTC_1618 st003135 44.5 µM -0.379678781602552 0.348227585809351 no 2215 0.352091936304681 3153 1270615
SGTC_155 k072-0202 43.6 µM -0.380081197331443 0.348084152347803 no 2216 0.351942571336241 3156 5857737
SGTC_225 nsc-122657 1.016 µM -0.380564250632005 0.347912005850938 no 2217 0.351763306226172 3175 275685
SGTC_3230 9131665 49.47 µM -0.381689064816378 0.347511275493393 no 2218 0.351346006058804 3050 15943720
SGTC_2004 4023728 41.89 µM -0.381735563581166 0.347494713339496 no 2219 0.351328759113053 3235 360084 YDR527W RBA50
SGTC_3228 9131799 49.47 µM -0.383174234913431 0.346982424448409 no 2220 0.350795290200177 3137 17015818
SGTC_1920 st075728 45.7 µM -0.383249490941363 0.34695563461229 no 2221 0.350767392847269 3242 3400306
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.384029651899953 0.346677955983156 no 2222 0.350478235197489 3159 4213774
SGTC_1491 4138-0063 26.5 µM -0.38652895596874 0.345788946801876 no 2223 0.349552480981648 3174 23883227
SGTC_736 0958-0254 92.6 µM -0.387926942709749 0.345292049336292 no 2224 0.349035049510385 3194 6812352
SGTC_152 4469-0003 551.229 µM -0.387971753088493 0.345276126434074 no 2225 0.349018468652352 3185 697280
SGTC_3248 9135562 49.47 µM -0.388017925142112 0.345259719961325 no 2226 0.349001384245216 3134 17650701
SGTC_218 alverine citrate 93.75 µM -0.388719116278077 0.345010599088194 no 2227 0.348741969813015 3217 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_553 k007-0256 45.7 µM -0.390302032980497 0.344448463721182 no 2228 0.348156610088014 3137 6287000
SGTC_2217 6934799 96.0675 µM -0.39080624947525 0.344269475232295 no 2229 0.347970227605833 3173 675606
SGTC_1137 ixabepilone 100 µM -0.391140818628289 0.344150727980537 no 2230 0.34784657514388 3059 154225 A novel microtubule stabilizer.
SGTC_2755 lomerizine 42.69 µM -0.392022811159001 0.343837759675569 no 2231 0.347520679614538 3124 3949 A calcium channel blocker.
SGTC_2084 5306078 60.6385 µM -0.392391731834281 0.343706882714515 no 2232 0.347384397127939 3104 679340
SGTC_3003 9075612 71.4286 µM -0.392557510392616 0.34364807781267 no 2233 0.347323163518441 3159 6501993
SGTC_1753 st043925 64 µM -0.39330991586746 0.343381232422966 no 2234 0.347045297688994 3191 670181
SGTC_165 k038-0023 64.381 µM -0.394400846872943 0.342994465454825 no 2235 0.346642559321754 3099 46368543
SGTC_752 1896-0090 130 µM -0.394750160015916 0.342870658462018 no 2236 0.346513640189473 3091 772567
SGTC_1706 st031321 9.9705 µM -0.395392820669772 0.342642924446145 no 2237 0.346276503306082 3196 6103185
SGTC_410 α-linolenic acid 100 µM -0.396014482427622 0.342422686030816 no 2238 0.34604717218324 3233 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_903 1134-0042 114 µM -0.396297568489025 0.342322413829556 no 2239 0.345942760391055 3110 701009
SGTC_564 3555-0129 330 µM -0.396853875071927 0.342125396297574 no 2240 0.345737609686185 3154 563260
SGTC_2356 9061756 188.97 µM -0.397958930436919 0.341734165348475 no 2241 0.345330229765441 3158 20104043
SGTC_1860 st056228 74.6 µM -0.398069769499042 0.341694933543295 no 2242 0.34528937869548 3222 688679
SGTC_532 1548-0774 215 µM -0.398261675572078 0.341627011879445 no 2243 0.345218653665323 3306 5932993
SGTC_1032 k061-1018 98.7 µM -0.398325736193008 0.341604339929325 no 2244 0.345195045978646 3292 4005393
SGTC_572 0960-0087 17.7 µM -0.399234906511756 0.341282633472035 no 2245 0.344860062567555 3133 6796365
SGTC_3133 9127736 49.47 µM -0.399710342304551 0.341114448228236 no 2246 0.344684936848255 3295 27243420
SGTC_1832 st054113 55 µM -0.400078283780187 0.340984310723903 no 2247 0.344549429262365 3231 1251267
SGTC_2021 4019055 173 µM -0.400198727537958 0.34094171498728 no 2248 0.344505075880586 3265 44827708 YER133W GLC7
SGTC_2082 5219693 150 µM -0.401389545657662 0.340520683426437 no 2249 0.344066672567567 3091 2834649
SGTC_2315 7733312 200 µM -0.401738611832582 0.340397303487627 no 2250 0.343938202476225 3091 726316
SGTC_2947 9072639 7.68 µM -0.40463629490708 0.339373757169741 no 2251 0.342872437754159 3192 16488146
SGTC_1723 st034307 2.5525 µM -0.405083927355671 0.339215745695614 no 2252 0.342707910197568 3170 867466
SGTC_1320 1313-0481 95.3 µM -0.405359185327312 0.339118595377181 no 2253 0.342606753786243 3281 6813365 YLR208W SEC13
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.405945508262502 0.33891169258418 no 2254 0.342391319642937 3185 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_862 0452-0056 10.2 µM -0.409160960768427 0.33777788264256 no 2255 0.341210770879422 3199 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_898 1000-0849 28.3 µM -0.410280218366982 0.33738356249669 no 2256 0.340800200719067 3207 6751807
SGTC_330 1488-0319 80.1 µM -0.411407519506866 0.336986589015769 no 2257 0.340386870529642 3188 6846614
SGTC_255 tunicamycin 200.472 nM -0.414011622670532 0.336070261514094 no 2258 0.33943279746398 3184 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2387 9077560 195.08 µM -0.414266029569537 0.33598079333996 no 2259 0.33933964468493 3131 5303272
SGTC_3089 9117425 49.47 µM -0.416492871177729 0.335198069205674 no 2260 0.338524691399375 3205 9401657
SGTC_2912 7964298 10.93 µM -0.416689321126403 0.335129052265017 no 2261 0.338452833174452 3220 2975850
SGTC_2295 7971645 200 µM -0.417346795218146 0.334898108479809 no 2262 0.33821238254619 3143 2978226 YKL099C UTP11
SGTC_2018 5133068 143 µM -0.417960357346855 0.334682645476387 no 2263 0.337988050853559 3104 785362
SGTC_2855 9016525 58.44 µM -0.419405447206245 0.334175392201074 no 2264 0.337459921894911 3117 43811474
SGTC_1512 0259-0544 12.2 µM -0.41957547152324 0.334115730406536 no 2265 0.337397805074582 3159 18476
SGTC_2234 tolnaftate 200 µM -0.420003710611671 0.33396547922762 no 2266 0.33724137150137 3179 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_358 0075-0058 9.45 µM -0.420152499368139 0.333913281706173 no 2267 0.337187026305507 3369 1069125
SGTC_164 4100-3994 89.624 µM -0.421457281356682 0.333455680650972 no 2268 0.336710599416601 3280 4615967
SGTC_2353 9059630 146.67 µM -0.423455117376268 0.332755498291812 no 2269 0.335981619200277 3233 4779114
SGTC_1776 st049249 45.9 µM -0.42701229441383 0.331510257151503 no 2270 0.334685186461065 3203 1822314
SGTC_1796 st049173 110.4 µM -0.428166505032613 0.331106608081724 no 2271 0.334264950226495 3252 94134
SGTC_2193 5925765 200 µM -0.428657458688581 0.330934971843048 no 2272 0.334086261956043 3231 877370
SGTC_2639 lactacystin 53 µM -0.429750096442862 0.330553115827731 no 2273 0.333688718800831 3304 3870 A proteasome inhibitor.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.429831734091823 0.330524592103974 no 2274 0.33365902340857 3177 260807
SGTC_1400 3771-8998 51.5 µM -0.430135325989459 0.33041852748394 no 2275 0.333548602124787 3151 670767
SGTC_3221 9128209 49.47 µM -0.430649240437392 0.330239014409753 no 2276 0.333361715993648 3174 16460723
SGTC_2257 7960413 200 µM -0.430863248506952 0.330164271762057 no 2277 0.33328390367806 3134 2974689 YIL048W NEO1
SGTC_1797 st048695 56.8 µM -0.430882991629229 0.33015737678762 no 2278 0.333276725534191 3252 592262 YIL048W NEO1
SGTC_698 k064-0052 127 µM -0.432417358137134 0.329621700046105 no 2279 0.332719052223263 3269 5088751
SGTC_2885 9057732 51.95 µM -0.433871441835527 0.329114373944786 no 2280 0.332190899452578 3307 6471414
SGTC_2232 chlorophetanol 41.5365 µM -0.434104656168637 0.329033035305217 no 2281 0.332106222236754 3264 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2268 7933382 153.85 µM -0.435384825345664 0.328586692334282 no 2282 0.331641561549524 3256 935025 YOR257W CDC31
SGTC_2135 5326629 150.42 µM -0.436078794863119 0.328344835498492 no 2283 0.331389780871832 3176 5020077
SGTC_1254 0550-0035 264 µM -0.436216727241722 0.32829677294825 no 2284 0.331339746380895 3278 15121435
SGTC_902 1120-0002 2.07 µM -0.437828208137974 0.327735463006565 no 2285 0.330755410528542 3203 3280475
SGTC_196 k015-0023 18.111 µM -0.439278839805452 0.327230512608246 no 2286 0.330229752338557 3177 5211998
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.43964082715344 0.327104557660806 no 2287 0.33009863295269 3296 5282362
SGTC_557 1315-0110 16.2 µM -0.439681302844928 0.327090475205471 no 2288 0.330083973107675 3146 6833801
SGTC_804 1595-0054 20.9 µM -0.440558882814852 0.326785204832428 no 2289 0.329766187591472 3174 761523 Stimulates phospholipase C.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.441227878550859 0.326552569324289 no 2290 0.329524016212852 3325 1273210
SGTC_2685 mycophenolic acid 18.85 µM -0.442335064357391 0.326167706486588 no 2291 0.329123380424161 3192 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2932 9016711 44.54 µM -0.44283008857318 0.325995693652571 no 2292 0.328944319076364 3299 7117328
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.444046530019872 0.325573157438389 no 2293 0.328504471751103 3176 641818 YHR062C RPP1
SGTC_876 0720-0963 56.8 µM -0.444053205357662 0.325570839348462 no 2294 0.328502058702008 3354 765861
SGTC_727 3032-0951 202 µM -0.444210976327101 0.325516053479138 no 2295 0.328445028600231 3210 3652836
SGTC_1959 st077091 55.8 µM -0.44594969916586 0.3249125329728 no 2296 0.327816790500543 3138 821356 YKL052C ASK1
SGTC_33 0986-0033 35.816 µM -0.447621724400366 0.324332596641552 no 2297 0.327213110942945 3251 2848082
SGTC_2360 9040895 200 µM -0.448123742043959 0.324158556570478 no 2298 0.327031947118109 3221 4914414
SGTC_1375 2910-0797 186 µM -0.44929670902601 0.323752060790426 no 2299 0.326608815752544 3207 742508
SGTC_827 3253-0474 693 µM -0.450603766301487 0.32329934312065 no 2300 0.326137575838208 3302 5402065
SGTC_339 3091-4833 71.4 µM -0.450822760231512 0.323223517055019 no 2301 0.326058647979447 3235 3240077
SGTC_2830 7992007 71.43 µM -0.451061603028438 0.323140826744244 no 2302 0.325972575250751 3133 1952075
SGTC_2293 7624732 200 µM -0.451193436517014 0.323095188113414 no 2303 0.325925069863388 3204 894453
SGTC_1454 4239-0054 42.6 µM -0.451239307442818 0.323079308962007 no 2304 0.325908541219795 3366 1340767
SGTC_575 k072-0246 11.9 µM -0.453289903658615 0.322369783219959 no 2305 0.325170001003269 3257 6796779
SGTC_1050 3232-1156 69.3 µM -0.45397414915563 0.322133171535455 no 2306 0.32492371654296 3223 700529
SGTC_2953 9074162 66.49 µM -0.454553636837882 0.321932841397695 no 2307 0.324715197990024 3290 16451992
SGTC_2088 5278280 127.392 µM -0.455343726655632 0.321659789016726 no 2308 0.324430986419624 3305 791502
SGTC_2159 5658611 73.75 µM -0.455888881204222 0.321471441579826 no 2309 0.324234942702945 3313 793844
SGTC_305 1682-2595 20.8 µM -0.456818647596988 0.321150319084747 no 2310 0.323900700655603 3267 226033
SGTC_472 calcifediol 10 µM -0.458981658192015 0.320403776596393 no 2311 0.323123668788943 3261 5283731 A vitamin D metabolite.
SGTC_1754 st042065 16.137 µM -0.45906484386064 0.320375080337721 no 2312 0.323093800857586 3298 1126236 YIL048W NEO1
SGTC_3346 9158254 43.5805 µM -0.459130772486961 0.320352337941293 no 2313 0.323070129901727 3267 17639500
SGTC_2931 9014674 55.67 µM -0.460719741185811 0.319804419804644 no 2314 0.32249984490473 3165 2996810
SGTC_1300 1094-0077 113 µM -0.463217303493731 0.318943989270215 no 2315 0.321604307255896 3213 5532636
SGTC_3057 9095946 49.47 µM -0.464128656227807 0.318630263335825 no 2316 0.321277785970184 3257 24540043
SGTC_2279 7948423 32.93 µM -0.464827725212616 0.318389702461323 no 2317 0.321027415704707 3375 1247112
SGTC_3205 9113483 49.47 µM -0.465705022869775 0.318087918560645 no 2318 0.320713328276517 3346 17018033
SGTC_407 eburnamonine 100 µM -0.466003300701154 0.317985340687581 no 2319 0.320606568974559 3215 3195
SGTC_960 1222-0186 7.7 µM -0.466066856660747 0.317963485570324 no 2320 0.320583823006747 3326 3126296
SGTC_1178 0988-0033 191 µM -0.46672602883106 0.317736852091424 no 2321 0.320347952396723 3317 5392207
SGTC_671 0560-0003 407 µM -0.466746196672512 0.317729919154861 no 2322 0.320340736911111 3217 3238678
SGTC_2841 9004761 38.96 µM -0.467676803509363 0.317410081474045 no 2323 0.320007865909701 3225 2991039
SGTC_2308 7584454 197.62 µM -0.468387174677287 0.317166027680189 no 2324 0.319753869004136 3401 893577
SGTC_594 1487-1584 10.8 µM -0.469925071190216 0.316637943270269 no 2325 0.319204275722291 3220 5013332
SGTC_775 4577-0580 57.3 µM -0.470806264773305 0.316335526399842 no 2326 0.318889545182445 3417 2006902
SGTC_157 1348-1695 65.819 µM -0.472583443226873 0.315725990126189 no 2327 0.318255198518213 3314 5380510
SGTC_484 loperamide 105 µM -0.472702097687259 0.315685311864132 no 2328 0.318212864903392 3244 3955 An opioid-receptor agonist.
SGTC_2176 5809774 33.9695 µM -0.472833822976935 0.315640155150044 no 2329 0.318165870650785 3308 2870539
SGTC_1006 4099-6547 255 µM -0.473543148968175 0.315397038610721 no 2330 0.317912862174836 3347 3146833
SGTC_3126 9127922 49.47 µM -0.473959616640045 0.315254334439325 no 2331 0.317764352498762 3400 45595682
SGTC_1749 st037932 54.2 µM -0.474868737583219 0.314942916590908 no 2332 0.317440267711542 3333 594497
SGTC_227 fluconazole 33.516 µM -0.477519925750986 0.314035508180967 no 2333 0.316495967720036 3279 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_650 1328-0195 38 µM -0.478307319966112 0.313766226929694 no 2334 0.3162157435856 3328 2780821
SGTC_1427 4048-4900 550 nM -0.479938714198082 0.313208621516283 no 2335 0.315635485932816 3355 24132586
SGTC_2063 5246145 200 µM -0.480017765286921 0.313181612935303 no 2336 0.315607380405774 3350 711240
SGTC_2389 9091542 195.52 µM -0.480671930523027 0.312958149428721 no 2337 0.315374841896926 3274 3626624 YOL127W RPL25
SGTC_3305 9127027 53.8275 µM -0.48102509115061 0.312837537950798 no 2338 0.31524933298007 3227 41905295
SGTC_2606 farnesol 9.78 µM -0.481532594808026 0.312664250295325 no 2339 0.315069009794954 3389 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1886 st057356 49.9 µM -0.482134394732584 0.312458818735946 no 2340 0.314855238925975 3229 24207747
SGTC_1792 st045773 43.6 µM -0.482540318947578 0.312320284581193 no 2341 0.314711081883478 3242 2919270
SGTC_1163 k060-0048 49.9 µM -0.482624780438079 0.312291462826541 no 2342 0.314681090377584 3274 6809982
SGTC_1932 st074806 40.9 µM -0.483472866417687 0.312002124496744 no 2343 0.314380010566529 3448 17251235
SGTC_1912 st060209 90.8 µM -0.483866610356275 0.311867831749206 no 2344 0.314240269099703 3269 688787
SGTC_916 4466-0038 42 nM -0.48431832724634 0.311713797189705 no 2345 0.314079985565566 3443 5722064 YGL116W CDC20
SGTC_2804 7954240 19.48 µM -0.485438821171606 0.311331853215111 no 2346 0.313682550055266 3348 828705
SGTC_2174 5790901 200 µM -0.485485312810869 0.311316009943447 no 2347 0.31366606429073 3324 786020
SGTC_3169 9102970 49.47 µM -0.485673211838962 0.311251981876325 no 2348 0.313599439776616 3347 17027839
SGTC_579 4491-1009 110 µM -0.486851545940838 0.310850585543002 no 2349 0.313181769289233 3412 1271041
SGTC_540 1187-0821 17.3 µM -0.487639460557708 0.310582310032059 no 2350 0.312902619899215 3253 847520
SGTC_394 menadione 8.33 µM -0.488083706454236 0.310431094000337 no 2351 0.312745275783236 3346 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2488 5268135 45.7 µM -0.488122316230182 0.310417953203445 no 2352 0.312731602487707 3352 1270356 YLR208W SEC13
SGTC_2591 skatole 100 µM -0.48914224088879 0.31007091057751 no 2353 0.312370498951389 3343 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_187 1488-2104 32.728 µM -0.492967135885322 0.308770948632555 no 2354 0.311017904362357 3320 2852859
SGTC_2764 methyldopa 94.69 µM -0.493570520034489 0.308566095327245 no 2355 0.310804762397754 3426 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3164 9100705 49.47 µM -0.49501597641474 0.308075594753682 no 2356 0.310294421526147 3405 17174235
SGTC_318 1488-0629 67.2 µM -0.495738159312808 0.307830657795216 no 2357 0.310039580312672 3353 3662576
SGTC_2186 6124449 200 µM -0.496174226077836 0.307682801984968 no 2358 0.309885746858513 3360 3834182 YLR033W RSC58
SGTC_555 4296-0685 37 µM -0.496653170055792 0.307520443917961 no 2359 0.309716825746334 3327 2908540 YHR072W ERG7
SGTC_2697 mebhydrolin 72.4 µM -0.497155328132131 0.307350256946993 no 2360 0.309539760284384 3414 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2320 7373003 200 µM -0.497753648002739 0.307147533818787 no 2361 0.309328845015544 3332 5415828
SGTC_389 tpck 16.7 µM -0.499743680119351 0.306473694051807 no 2362 0.308627785850445 3334 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_274 sirtinol 40.1 µM -0.500608077417493 0.30618120619433 no 2363 0.308323488305947 3306 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2659 sanguinarine 24.21 µM -0.501735854354479 0.305799783722098 no 2364 0.307926670035422 3254 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_21 0849-0113 22.993 µM -0.502018841775397 0.30570410832095 no 2365 0.30782713362853 3304 1560156
SGTC_2444 5485484 36.41 µM -0.50311679430538 0.30533302642793 no 2366 0.307441079877418 3380 6790631
SGTC_1780 st038448 24.544 µM -0.503332232844022 0.305260236771258 no 2367 0.307365354020339 3411 728868 YDL195W SEC31
SGTC_1377 2944-0135 198 µM -0.503349880308686 0.305254274609629 no 2368 0.307359151364973 3339 1894137
SGTC_2747 doxorubicin 7.63 µM -0.503378938019553 0.305244457631087 no 2369 0.307348938405147 3268 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_938 3126-1755 342 µM -0.504647363246247 0.304816064159275 no 2370 0.306903268649372 3402 1777771
SGTC_363 0455-0021 3.06 µM -0.504668303035101 0.304808994271189 no 2371 0.306895913704751 3332 4597466
SGTC_2432 5630864 12.22 µM -0.504757133294127 0.304779003375655 no 2372 0.306864713603209 3391 5714970
SGTC_3046 9092212 49.47 µM -0.504975430874549 0.304705307261961 no 2373 0.306788046273876 3341 25236637
SGTC_2940 9060638 45.86 µM -0.50500859782433 0.304694110967753 no 2374 0.306776398595361 3336 4027022
SGTC_139 0099-0334 718.624 µM -0.50589587672376 0.3043946567669 no 2375 0.306464873523283 3358 97690
SGTC_499 genistein 192 µM -0.505930302563179 0.304383040780856 no 2376 0.306452789370971 3372 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3088 9117578 49.47 µM -0.506262862619076 0.30427083834261 no 2377 0.306336065035125 3408 678341
SGTC_603 3794-0023 45.9 µM -0.50716500919957 0.303966555909723 no 2378 0.306019522081092 3370 3802260
SGTC_295 k015-0027 31 µM -0.508687485540872 0.303453352178102 no 2379 0.305485647834029 3352 3887424
SGTC_2078 5212016 200 µM -0.508818575243893 0.303409181927641 no 2380 0.305439698999341 3339 1899708
SGTC_2031 5180455 200 µM -0.508921032998903 0.303374661119396 no 2381 0.305403788209785 3316 29949
SGTC_66 0109-0187 42.4 µM -0.509753625793099 0.303094203036581 no 2382 0.30511203920266 3412 759417
SGTC_1380 2291-0730 164 µM -0.509910647115742 0.303041323556536 no 2383 0.305057031200334 3318 2999191
SGTC_1804 st050076 49.1 µM -0.510970943779942 0.302684359534829 no 2384 0.304685701425342 3385 3895976
SGTC_80 0159-0065 512.242 µM -0.511276398740323 0.302581558720448 no 2385 0.304578764401517 3364 1548079
SGTC_672 1441-0018 53.7 µM -0.51216390672009 0.302282956885994 no 2386 0.30426815064564 3277 251141
SGTC_617 3770-0098 35 µM -0.51220400071755 0.302269470392587 no 2387 0.304254121711806 3310 5962639
SGTC_1213 1315-0166 115 µM -0.515734770749721 0.301082879086098 no 2388 0.303019833068971 3336 768401
SGTC_830 4076-0286 57.8 µM -0.515843521536608 0.301046364388495 no 2389 0.302981851494853 3395 6866659
SGTC_1442 4112-3290 3 µM -0.515924610649057 0.301019138809493 no 2390 0.30295353223919 3321 704353
SGTC_3139 9095020 49.47 µM -0.516376382800546 0.300867477135425 no 2391 0.302795778728486 3270 25236292
SGTC_1038 k292-0204 154 µM -0.516726124969862 0.300750090997576 no 2392 0.30267367815377 3330 4454212
SGTC_635 k038-0028 24.7 µM -0.517186432836592 0.300595626514138 no 2393 0.30251301096029 3336 4035102
SGTC_2832 7992762 51.95 µM -0.517428541725857 0.300514396950976 no 2394 0.302428519917403 3176 2985177
SGTC_1135 dihydrocapsaicin 536.708 nM -0.517786515019545 0.300394312076477 no 2395 0.302303613965275 3332 107982 A Capsaicinoid.
SGTC_1874 staurosporine 7.6 µM -0.519500763058951 0.299819555235628 no 2396 0.301705790460667 3402 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_931 2812-0076 566 µM -0.51988119352168 0.299692071216753 no 2397 0.301573191993988 3285 3450959
SGTC_3339 9145883 14.936 µM -0.520030156830688 0.29964215960909 no 2398 0.301521278199666 3386 2030670
SGTC_492 tmb-8 126 µM -0.522271329481806 0.298891687907337 no 2399 0.300740714165849 3326 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_459 nigericin 15.3 µM -0.52340255399466 0.298513214351269 no 2400 0.300347073625427 3444 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1449 4112-4002 201 µM -0.523859965362623 0.298360240248679 no 2401 0.300187970950649 3354 2059539
SGTC_655 k060-0012 42 µM -0.524603009679909 0.29811181675154 no 2402 0.299929597037059 3304 5994525
SGTC_291 SEC14.278 35.5 µM -0.52472905929131 0.298069683682841 no 2403 0.299885776621687 3423 1068044
SGTC_3019 9081971 49.47 µM -0.524961281730451 0.297992068620865 no 2404 0.29980505342799 3469 16451803
SGTC_676 falcarinol 140 µM -0.525372668154887 0.297854594695339 no 2405 0.299662074928731 3477 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2986 9022445 71.43 µM -0.526224952825584 0.297569876877259 no 2406 0.29936595935145 3411 6459286
SGTC_2252 omeprazole 400 µM -0.526783002901125 0.297383519642027 no 2407 0.299172143800687 3274 4594 A proton pump inhibitor.
SGTC_2094 5332512 191.667 µM -0.527316186084927 0.297205516362552 no 2408 0.298987017949541 3432 755774
SGTC_2789 5281112 71.43 µM -0.527583534813903 0.297116280288169 no 2409 0.29889421172668 3338 765948
SGTC_59 0330-0160 1.33 µM -0.52841401488408 0.296839159523844 no 2410 0.298606006152617 3413 4293482
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.52848167596092 0.296816587085197 no 2411 0.298582530965812 3380 688788
SGTC_1133 3473-0247 50 µM -0.528505086194955 0.296808777370694 no 2412 0.298574408919604 3301 711311
SGTC_2239 6685329 187.64 µM -0.528508295141527 0.296807706865165 no 2413 0.298573295601857 3408 805680
SGTC_1057 3448-5381 134 µM -0.53026094126164 0.296223287882501 no 2414 0.297965511738291 3396 5497911
SGTC_3042 9091578 49.47 µM -0.530946793519979 0.295994734564938 no 2415 0.297727825029157 3398 25236497
SGTC_531 3788-1495 174 µM -0.530968808918577 0.295987399497522 no 2416 0.297720196877889 3317 2896655
SGTC_835 0312-0010 67.2 µM -0.532253532980861 0.295559501081989 no 2417 0.297275205264501 3353 1626196
SGTC_2700 st077718 96.8 µM -0.534361367496554 0.294858069062717 no 2418 0.296545770951772 3362 904970
SGTC_83 0170-0301 39.027 µM -0.53668742812726 0.29408490890432 no 2419 0.295741770754186 3383 3089716
SGTC_2284 7945075 39.21 µM -0.53709846580144 0.293948381418376 no 2420 0.295599800250074 3417 1245402
SGTC_2066 5222451 176 µM -0.537447564524887 0.293832450176232 no 2421 0.295479247782445 3377 2281147
SGTC_2771 fluoxetine 41.05 µM -0.538198177265022 0.293583252899699 no 2422 0.295220119149759 3473 3386 A selective serotonin reuptake inhibitor.
SGTC_2635 hydroquinidine 100 µM -0.539250252630191 0.293234137295003 no 2423 0.294857094922135 3390 442912 An experimental heart treatment.
SGTC_1018 4259-0013 28.1 µM -0.539772769426606 0.293060819404495 no 2424 0.294676874214549 3420 6801262
SGTC_972 1319-0219 195 µM -0.541233420093169 0.29257657643758 no 2425 0.294173352477258 3388 23903702
SGTC_384 k007-0144 5.16 µM -0.541516549001853 0.29248275501478 no 2426 0.294075797086295 3382 6824886
SGTC_1388 3346-4487 254 µM -0.541527141452044 0.292479245228675 no 2427 0.294072147623367 3420 3345614
SGTC_905 2-aminofluorene 215 µM -0.542626578450109 0.292115055606425 no 2428 0.293693467715484 3463 1539 An established DNA mutagen. YPR165W RHO1
SGTC_233 rapamycin 362 pM -0.542788409078198 0.292061466870533 no 2429 0.293637747331688 3445 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2333 9017922 200 µM -0.543424057197983 0.291851022096454 no 2430 0.293418932817417 3447 3163164
SGTC_955 1216-0110 33 µM -0.543847488801826 0.291710875305928 no 2431 0.293273213318481 3401 3619719
SGTC_1020 4335-0961 93.3 µM -0.546247800903485 0.290917016893089 no 2432 0.292447806085146 3275 669075
SGTC_2223 6903751 107.57 µM -0.546321092092622 0.290892793093641 no 2433 0.292422620079285 3409 5598863
SGTC_3292 9120825 59.784 µM -0.546420679810786 0.290859879421378 no 2434 0.292388399070775 3492 24824900
SGTC_1324 1418-0026 34.4 µM -0.547128455848397 0.290626010093232 no 2435 0.292145241918682 3425 1372513
SGTC_621 3584-0052 32.1 µM -0.547498744491573 0.290503691257725 no 2436 0.292018066397033 3463 2273927
SGTC_1129 3453-1384 223 µM -0.549026948207125 0.289999129083996 no 2437 0.29149347817968 3491 1084452
SGTC_1849 st056239 19.2 µM -0.549353272301103 0.28989144094941 no 2438 0.291381517513373 3333 5393181
SGTC_647 0140-0236 81 µM -0.549374096605146 0.289884569490201 no 2439 0.291374373447916 3408 990837
SGTC_2366 9070441 60.58 µM -0.549477478085452 0.289850457518437 no 2440 0.291338908211623 3363 6837235
SGTC_2089 5281248 129.67 µM -0.54951284669735 0.289838787648787 no 2441 0.29132677539672 3452 2737878
SGTC_2853 9015042 58.44 µM -0.549564665372417 0.289821690480595 no 2442 0.291308999993656 3331 6457456
SGTC_1687 st020778 55.3625 µM -0.549960464878899 0.289691115127378 no 2443 0.291173245262591 3433 4259299
SGTC_1180 1193-0155 285 µM -0.550426598190582 0.289537371871948 no 2444 0.291013404726439 3447 2921347
SGTC_2022 5136654 200 µM -0.551472264940879 0.289192622412091 no 2445 0.29065498712305 3420 1713771
SGTC_2869 9037858 32.47 µM -0.553588158424724 0.288495617189773 no 2446 0.289930365968338 3421 27187042
SGTC_780 0109-0199 192 µM -0.554109796136897 0.288323904075772 no 2447 0.289751853147679 3497 610414
SGTC_3218 9131285 49.47 µM -0.554466747753454 0.288206430239585 no 2448 0.289629728287721 3518 17156417
SGTC_2878 9043973 25.97 µM -0.556347897424923 0.287587711633222 no 2449 0.288986524816831 3491 6465167
SGTC_2514 salinomycin 42.74 µM -0.557133507668992 0.287329506877908 no 2450 0.288718107709604 3480 23682228 A polyether potassium ionophore.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.557358556184651 0.287255560903007 no 2451 0.288641237692997 3500 688801
SGTC_303 1348-1668 34.2 µM -0.557581409578819 0.287182345072568 no 2452 0.288565126966737 3427 5380509
SGTC_3237 9133362 49.47 µM -0.557761738858551 0.287123106500644 no 2453 0.288503546348313 3432 43845137
SGTC_956 1185-0240 191 µM -0.557975191158737 0.287052994420333 no 2454 0.288430662559199 3393 1416193
SGTC_568 1193-0097 7.48 µM -0.559150891134693 0.286666960927664 no 2455 0.288029372676706 3387 3646150
SGTC_2447 5741742 33.78 µM -0.560890241677405 0.286096308326685 no 2456 0.287436181382547 3452 1776504
SGTC_2807 7945238 51.95 µM -0.560936941375441 0.286080994358616 no 2457 0.287420262800059 3449 17148797
SGTC_601 0986-0029 62.9 µM -0.562963967625106 0.285416658738716 no 2458 0.286729710101486 3465 24747981
SGTC_3008 9078912 71.4286 µM -0.564144918574385 0.285029953997597 no 2459 0.286327755197135 3437 16648731
SGTC_310 1273-0058 1.06 µM -0.565786374534583 0.284492871278962 no 2460 0.285769505020542 3486 2734232
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.565935419248156 0.284444127950366 no 2461 0.285718841378145 3464 16486 A toxic proline analog.
SGTC_3184 9108758 49.47 µM -0.567340493974004 0.28398481092358 no 2462 0.285241435087825 3452 902885
SGTC_543 3844-1095 191 µM -0.567536262890389 0.283920842508552 no 2463 0.285174948298266 3442 4230703
SGTC_552 k242-0005 476 µM -0.568964988777975 0.283454208527018 no 2464 0.284689950010422 3505 4088318
SGTC_1040 k898-0338 155 µM -0.570482106021845 0.282959107964963 no 2465 0.284175377641142 3531 20969351
SGTC_906 1165-0455 526 µM -0.573711837486782 0.281906492694714 no 2466 0.283081408279432 3466 3252859
SGTC_2399 5884133 200 µM -0.573863727922193 0.281857035932547 no 2467 0.283030010000009 3415 722445
SGTC_427 1354-0053 47.3 µM -0.574556958944642 0.281631367369761 no 2468 0.282795484106122 3549 6813657
SGTC_3342 9147791 14.508 µM -0.574782710400239 0.281557896961799 no 2469 0.282719130642474 3454 1838168
SGTC_1590 st077108 57.8 µM -0.575425327159053 0.281348809112935 no 2470 0.282501839599863 3479 5489485
SGTC_3117 9124945 49.47 µM -0.576709507127434 0.280931200873493 no 2471 0.2820678544906 3359 17592065
SGTC_122 0236-0016 402.397 µM -0.577457738007017 0.280688018533583 no 2472 0.281815140016536 3525 6808838
SGTC_2617 dihydrotanshinone i 20.83 µM -0.577561285522501 0.280654372602748 no 2473 0.281780175510189 3442 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2746 daunorubicin 9.88 µM -0.578074494880053 0.28048764311851 no 2474 0.281606912874501 3391 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2136 5328288 199.296 µM -0.579136781633714 0.280142683880161 no 2475 0.281248441656814 3411 262395
SGTC_39 0986-0283 58.349 µM -0.581587495761561 0.279347642002294 no 2476 0.280422283740986 3550 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3274 9138298 49.47 µM -0.584212737235716 0.278497199223851 no 2477 0.27953859653093 3469 17015756
SGTC_1564 D-Arginine 115 µM -0.584754317382544 0.278321912273042 no 2478 0.279356462649972 3435 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2770 toltrazuril 17.5 µM -0.585915417408101 0.277946293862349 no 2479 0.278966178091952 3506 68591 Kills coccidiodes.
SGTC_977 1348-1378 135 µM -0.58607460536723 0.277894815498588 no 2480 0.278912690375615 3472 X977
SGTC_43 0570-0105 72.5 µM -0.586338323083769 0.277809544438233 no 2481 0.27882409127282 3508 1114046 YDL195W SEC31
SGTC_516 3992-2719 87.3 µM -0.588550811704904 0.277094657163458 no 2482 0.278081319366665 3364 5350887 YDR037W KRS1
SGTC_2481 5478948 45.16 µM -0.590968167033363 0.276314605064579 no 2483 0.277270875109917 3521 77792
SGTC_951 1171-0579 82.7 µM -0.594239164582984 0.275260810788314 no 2484 0.276176080664448 3512 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1692 fluoroquinolonic acid 71 µM -0.594268289057373 0.275251436854065 no 2485 0.276166342315548 3518 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.594321190571951 0.275234410500011 no 2486 0.276148654070148 3489 5355888
SGTC_1238 0333-0287 48.8 µM -0.59526277800308 0.274931447327648 no 2487 0.275833916274295 3474 7226
SGTC_521 r062-0005 13.8 µM -0.59584407548803 0.274744492358887 no 2488 0.27563969809479 3463 2832033
SGTC_1887 st057648 70.8 µM -0.596933508203755 0.274394281529438 no 2489 0.275275887264745 3520 688672
SGTC_2331 7980721 200 µM -0.597527425972111 0.274203452597896 no 2490 0.275077650873331 3458 2981221
SGTC_1866 st057638 64 µM -0.600707711768541 0.273182726478116 no 2491 0.27401734085889 3472 688802
SGTC_3344 9148862 3.898 µM -0.60174919893317 0.272848866483424 no 2492 0.273670547690101 3574 4905352
SGTC_3309 9129340 25.759 µM -0.606050502468176 0.271472184533324 no 2493 0.272240608975192 3503 17158987
SGTC_3160 9100216 49.47 µM -0.606139712189321 0.271443668597898 no 2494 0.272210991166006 3486 17191039
SGTC_1976 st070609 63.5 µM -0.606928169652738 0.271191702640492 no 2495 0.271949291325935 3498 682556
SGTC_2898 9056270 58.44 µM -0.607278141566018 0.271079900113615 no 2496 0.271833170965134 3472 19154699
SGTC_354 2783-3500 4.88 µM -0.608007604548385 0.270846938746632 no 2497 0.271591215145728 3470 6740761
SGTC_451 chloral hydrate 100 µM -0.608044177164573 0.270835261543455 no 2498 0.271579087186178 3569 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3000 9075062 71.4286 µM -0.608562851929679 0.270669681891205 no 2499 0.271407116865671 3472 17057871
SGTC_3071 9117417 49.47 µM -0.609998315103044 0.27021169409579 no 2500 0.270931461845899 3446 45595590 YGL055W OLE1
SGTC_1594 piperine 70.1 µM -0.611310516514198 0.269793372569663 no 2501 0.270497015050796 3512 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_179 1273-0063 6.77 µM -0.611983003397052 0.269579113747973 no 2502 0.270274501460047 3476 3108139
SGTC_477 mead ethanolamide 10 µM -0.613108612866807 0.269220677925077 no 2503 0.269902262814409 3432 16061185
SGTC_2556 citropten 84.59 µM -0.613655417384512 0.269046641391111 no 2504 0.269721527415412 3467 2775 A potential DNA crosslinker.
SGTC_119 0121-0043 24.815 µM -0.614945711376596 0.268636191529782 no 2505 0.269295286717987 3612 1092378
SGTC_2206 7254556 146.969 µM -0.615516217907248 0.268454810530633 no 2506 0.269106931148248 3520 4398905
SGTC_3199 9111318 49.47 µM -0.616063782143893 0.268280781499586 no 2507 0.268926212285547 3504 8548020
SGTC_111 0083-0039 52.457 µM -0.616301093100378 0.26820537602525 no 2508 0.268847908777789 3466 759313
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.617416259404237 0.267851175182762 no 2509 0.268480100085282 3532 4330530
SGTC_1139 k015-0024 46.9 µM -0.617686260441775 0.267765452481051 no 2510 0.268391085299589 3545 2766652
SGTC_1479 0549-0158 134 µM -0.619348956834035 0.267237867404848 no 2511 0.267843249681032 3567 5440202
SGTC_2978 9011784 42.97 µM -0.620828022091428 0.266768991061988 no 2512 0.267356391862028 3566 2994934
SGTC_1972 st070201 17.4 µM -0.620837777491284 0.266765899897453 no 2513 0.267353182199868 3553 2829099
SGTC_831 k061-1017 217 µM -0.623417347491023 0.265949154998274 no 2514 0.266505150563529 3582 1240153
SGTC_2161 5662504 8.5105 µM -0.62579120264047 0.265198664649572 no 2515 0.265725951437038 3519 2859334
SGTC_1626 st003712 1.76 µM -0.625884717645099 0.265169122068338 no 2516 0.265695279541175 3538 24207035
SGTC_149 3970-0822 46.1 µM -0.627666813952155 0.264606454721926 no 2517 0.265111114757362 3606 3114250 YBL034C STU1
SGTC_638 3970-0837 4.09 µM -0.627710962118952 0.264592523383801 no 2518 0.265096651431412 3531 4118451 YLR208W SEC13
SGTC_2740 felodipine 17.08 µM -0.628608388086986 0.264309413717853 no 2519 0.264802733733858 3527 3333 L-type calcium channel blocker
SGTC_2316 5844804 197.44 µM -0.629904841275089 0.263900696033115 no 2520 0.264378422605727 3588 776813
SGTC_1275 0867-0008 21.1 µM -0.629945313912289 0.263887941884465 no 2521 0.264365182046515 3524 3422836
SGTC_1223 0764-0573 147 µM -0.631372000078433 0.263438550905915 no 2522 0.263898659704231 3586 1609797
SGTC_1398 3558-0053 112 µM -0.632346387515967 0.263131853893253 no 2523 0.263580279134628 3488 4532369
SGTC_1627 st003713 25.6 µM -0.63253638073388 0.263072073118856 no 2524 0.263518221795019 3574 16195070 YER133W GLC7
SGTC_1646 st011709 75.6 µM -0.633196481011193 0.262864428582415 no 2525 0.263302671718745 3555 5757843
SGTC_2628 lathosterol 100 µM -0.633381996826986 0.262806086863736 no 2526 0.263242109334724 3618 6710616
SGTC_3036 9090181 49.47 µM -0.633929656925021 0.262633895275039 no 2527 0.263063365008208 3584 25236586
SGTC_1070 indatraline 8.81 µM -0.635321452075009 0.262196556371909 no 2528 0.262609392660036 3551 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1569 carminic acid 40.6 µM -0.635789587913104 0.262049539594549 no 2529 0.262456787404531 3585 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1179 1021-1431 9.29 µM -0.636881163230066 0.261706897564459 no 2530 0.262101126678766 3540 2840958
SGTC_2243 6634756 200 µM -0.637304103948383 0.261574199631071 no 2531 0.261963389141016 3635 885676
SGTC_2526 patulin 37.61 µM -0.637532480152023 0.261502560806591 no 2532 0.26188903014128 3611 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1011 4112-3381 17.4 µM -0.638274186392125 0.261269966124584 no 2533 0.261647606223345 3631 2877139
SGTC_2429 5902844 64.44 µM -0.638865199000423 0.261084704192096 no 2534 0.261455314582371 3568 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2448 5185112 27.17 µM -0.639280434219047 0.260954582768555 no 2535 0.26132025722176 3560 5718189
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.640268951638655 0.260644947308145 no 2536 0.260998881189173 3617 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2536 dehydroabietamide 32.04 µM -0.641996747588593 0.260104200508105 no 2537 0.260437647382731 3607 3983547
SGTC_3193 9111931 49.47 µM -0.64261047830883 0.25991226103533 no 2538 0.260238441125286 3601 17087244
SGTC_357 1325-0123 420 µM -0.643166892009031 0.25973831017623 no 2539 0.260057906857108 3570 1098503
SGTC_802 4112-3352 742 µM -0.644592644263178 0.259292853565628 no 2540 0.25959560146695 3613 704594
SGTC_1415 3966-0071 78.1 µM -0.646161581618487 0.25880311738631 no 2541 0.259087358597182 3589 2893185
SGTC_2511 berberine 10.47 µM -0.647357962879989 0.258429994710686 no 2542 0.258700147895046 3594 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_271 rotenone 740 µM -0.652989180763075 0.256677502911822 no 2543 0.256881626762342 3637 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1197 1601-0112 267 µM -0.653122389955283 0.256636121916181 no 2544 0.256838689445544 3588 7350313
SGTC_3338 9144300 39.5675 µM -0.653469008747429 0.256528462216295 no 2545 0.256726981322781 3563 4901274
SGTC_740 k014-0057 261 µM -0.655502619907221 0.255897297395919 no 2546 0.256072100076483 3589 4012779
SGTC_788 1182-0090 188 µM -0.657324106270154 0.255332657790469 no 2547 0.255486269712626 3671 5715185
SGTC_520 3584-0023 682 µM -0.657466523352408 0.255288537615299 no 2548 0.255440494757156 3546 1340790
SGTC_2658 polymyxin b sulfate 77.05 µM -0.658319173095545 0.255024473918622 no 2549 0.255166530186117 3588 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_700 3453-2283 142 µM -0.658771437405399 0.254884466706553 no 2550 0.255021275701898 3672 565664
SGTC_3187 9109394 49.47 µM -0.660022668132567 0.254497333603746 no 2551 0.254619641342505 3575 17098090
SGTC_2897 9048598 12.99 µM -0.660085476465701 0.254477908713013 no 2552 0.254599489141058 3588 6467404
SGTC_270 tamoxifen 5.46 µM -0.663523871332623 0.253415694217377 no 2553 0.253497548074384 3711 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1806 st050005 60.3 µM -0.664715684718846 0.253048054949203 no 2554 0.253116179927218 3588 5194765
SGTC_1253 0550-0034 176 µM -0.665967294128113 0.252662272654042 no 2555 0.252716002782368 3594 5969915
SGTC_2138 5575593 77.673 µM -0.667932910786427 0.252057038437129 no 2556 0.252088209179915 3620 762213
SGTC_546 peri-Naphthalide 147 µM -0.669529225819897 0.251566079514844 no 2557 0.251578971972083 3575 223824 A penicillin ester.
SGTC_1924 st058459 75.1 µM -0.673024795315167 0.25049275729201 no 2558 0.250465758243921 3601 688683
SGTC_400 oxethazaine 37.5 µM -0.675152291853869 0.249840694713782 no 2559 0.249789506833968 3616 4621 A local anesthetic.
SGTC_2798 7813637 45.45 µM -0.675968332491476 0.24959082336756 no 2560 0.249530375571365 3630 956368
SGTC_163 TUB2.036 7.546 µM -0.676298085443163 0.249489890808388 no 2561 0.24942570404263 3663 15992207 YJR013W GPI14
SGTC_234 nsc-17383 10.7 µM -0.676958656015945 0.249287765071136 no 2562 0.249216093249164 3667 408974
SGTC_2571 chrysanthemic acid 100 µM -0.677087222360681 0.249248435617889 no 2563 0.249175307753944 3588 2743 An insecticide.
SGTC_2403 6032726 181.2 µM -0.678651932008499 0.248770043212951 no 2564 0.248679214764916 3642 2881040
SGTC_2052 5265182 7.135 µM -0.679521328275627 0.248504446506527 no 2565 0.24840379918707 3639 1239884
SGTC_1419 3993-2473 62.6 µM -0.679907647066503 0.248386476332336 no 2566 0.248281469655382 3679 704026
SGTC_2996 9066192 71.4286 µM -0.680424145902338 0.248228799721469 no 2567 0.248117968235914 3646 6472854
SGTC_3075 9116269 49.47 µM -0.680477657751301 0.248212466692097 no 2568 0.24810103195946 3653 17015205 YNL244C SUI1
SGTC_365 0121-0052 13.6 µM -0.680708087074184 0.248142140986966 no 2569 0.248028109088033 3656 3101739
SGTC_3341 9147222 25.867 µM -0.683983147356233 0.247143761394486 no 2570 0.246992903820736 3623 1939759
SGTC_1138 3761-0006 1.03 µM -0.685722787714342 0.246614318989221 no 2571 0.246443967037266 3628 12061087
SGTC_87 0100-0052 35.5 µM -0.686158532798232 0.246481799470413 no 2572 0.246306571820007 3721 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1885 st057546 99.9 µM -0.686837426684329 0.246275409190173 no 2573 0.246092590963764 3701 702008
SGTC_1896 st058441 89 µM -0.686918101133378 0.24625088954134 no 2574 0.246067169779717 3628 688759
SGTC_756 0508-1999 28.3 µM -0.687173974958402 0.246173129633696 no 2575 0.245986551147791 3636 6753853
SGTC_2155 5570423 76 µM -0.68751409602865 0.246069787425403 no 2576 0.245879410525796 3625 797402
SGTC_173 1273-0061 2.693 µM -0.687544516851889 0.24606054551229 no 2577 0.245869828964607 3621 2847414 YPL266W DIM1
SGTC_2540 epiandrosterone 100 µM -0.687794815674726 0.245984511247816 no 2578 0.245791000656216 3728 441302 A steroid.
SGTC_2963 9082507 9 µM -0.689299776242217 0.245527609306803 no 2579 0.245317319369987 3664 16459611
SGTC_2394 5221648 200 µM -0.689398116935627 0.245497769216833 no 2580 0.245286384055511 3722 788586
SGTC_3047 9092122 49.47 µM -0.690765742682099 0.245082984604322 no 2581 0.244856383554142 3627 17173831
SGTC_725 1497-0963 19 µM -0.691218306540168 0.244945810424154 no 2582 0.244714180591812 3686 3549977
SGTC_1807 st050092 58.9 µM -0.694302398836609 0.244012108921351 no 2583 0.243746293471437 3636 5008496
SGTC_588 3970-1144 52.9 µM -0.695049478740026 0.243786221497622 no 2584 0.243512147139525 3595 1888707
SGTC_281 1672-3440 14.9 µM -0.695532622191584 0.243640198143006 no 2585 0.243360787268975 3674 6833000
SGTC_3107 9121808 49.47 µM -0.695762989697672 0.243570589416577 no 2586 0.243288635311393 3611 662681
SGTC_2663 amphotericin b 100 µM -0.698651009069144 0.242698846512211 no 2587 0.24238507876341 3658 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2825 7998094 58.44 µM -0.70117714824304 0.241937723400575 no 2588 0.241596234536468 3660 2987815
SGTC_14 0354-0009 295 µM -0.701558654740785 0.241822888535097 no 2589 0.24147722175677 3710 1713507
SGTC_1606 st000094 49.2 µM -0.701777065462077 0.241757159416463 no 2590 0.241409101821492 3698 1242210
SGTC_2274 7947094 46.08 µM -0.703031767407703 0.241379753901055 no 2591 0.24101797620379 3673 2971028
SGTC_2079 5212404 121 µM -0.70307348447169 0.241367211202164 no 2592 0.241004977752449 3671 758462
SGTC_2823 7987624 58.44 µM -0.703734718219848 0.241168451222003 no 2593 0.24079899752146 3701 2239440
SGTC_463 ikarugamyin 104 µM -0.704631075491474 0.240899157669334 no 2594 0.24051992721405 3727 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2036 5160441 105 µM -0.705884711718052 0.240522800952103 no 2595 0.24012991787922 3694 134534 YIL048W NEO1
SGTC_1859 st055998 20 µM -0.705888861673271 0.2405215556174 no 2596 0.240128627390587 3682 676301
SGTC_1555 citronellol 128 µM -0.706877721609601 0.240224914797211 no 2597 0.239821234879371 3650 8842 A terpine precursor.
SGTC_1991 st073000 8.92 µM -0.708005784025404 0.239886759240777 no 2598 0.239470832802153 3741 4301969 YIL048W NEO1
SGTC_2057 5236571 38.335 µM -0.708056949550626 0.239871427677385 no 2599 0.239454946245972 3678 54684039 YBR257W POP4
SGTC_1094 duloxetine 25.4 µM -0.708259315295953 0.239810794756155 no 2600 0.239392118664259 3688 60834 A selective serotonin reuptake inhibitor.
SGTC_912 3474-0017 2.18 µM -0.70844478212037 0.239755232441637 no 2601 0.239334545522182 3719 3360550
SGTC_1492 4158-0558 28.5 µM -0.709709697835797 0.239376475259814 no 2602 0.238942088537386 3695 3967268
SGTC_2965 9082772 38.63 µM -0.711225220790165 0.238923108740813 no 2603 0.23847234106533 3696 16459634
SGTC_378 3970-0959 8.33 µM -0.711768311709297 0.238760758223969 no 2604 0.238304129184362 3702 6615653
SGTC_470 aa-861 153 µM -0.713225523780142 0.238325440526364 no 2605 0.237853107308743 3689 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_432 NS 1619 61.3 µM -0.71418405469983 0.238039332654415 no 2606 0.237556687712535 3734 4552 A K+/calcium channel activator.
SGTC_2921 7974240 10.71 µM -0.718557799798172 0.236736224322227 no 2607 0.236206711367543 3726 2979074 YDR527W RBA50
SGTC_987 1497-1013 404 µM -0.71927059767443 0.236524226618887 no 2608 0.235987104157721 3695 1676435
SGTC_946 3434-1334 87.4 µM -0.720515034883545 0.236154361255279 no 2609 0.235603973042468 3698 4047976
SGTC_81 0411-0046 9.971 µM -0.721122483338304 0.235973934261222 no 2610 0.235417079541488 3619 12925265
SGTC_1877 wortmannin 25 µM -0.721970377916253 0.235722215985112 no 2611 0.235156344914232 3707 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2856 9022925 19.48 µM -0.722040771265699 0.235701324653929 no 2612 0.235134705546577 3702 4944862
SGTC_2787 5284540 71.43 µM -0.722077939741522 0.235690294209333 no 2613 0.235123280162103 3736 736958
SGTC_114 0364-0001 490.298 µM -0.722917980465356 0.235441072259223 no 2614 0.23486513807127 3739 4003655
SGTC_1617 st002906 78 µM -0.723693234594312 0.235211200193338 no 2615 0.234627043765518 3738 5150859
SGTC_1631 benzylvanillin 81.9 µM -0.725681458094529 0.234622235160882 no 2616 0.234017035614645 3740 75506
SGTC_1372 2752-0194 270 µM -0.726153710043631 0.234482461454996 no 2617 0.233872272903567 3694 823334
SGTC_2975 9084847 53.72 µM -0.726774997437345 0.234298647509027 no 2618 0.233681900914125 3770 27211724
SGTC_2182 6325192 200 µM -0.727185073505549 0.234177366205314 no 2619 0.233556294395546 3658 736248
SGTC_352 k048-0007 5.11 µM -0.728636529010592 0.233748372988138 no 2620 0.233112013732475 3734 6811911
SGTC_257 daunorubicin 18.5 µM -0.728854019487594 0.233684128896274 no 2621 0.233045481821678 3767 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1872 amphotericin b 148 nM -0.730978316541157 0.233057151891441 no 2622 0.232396198741192 3739 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_479 n-linoleoylglycine 10 µM -0.734571233151778 0.231998847391915 no 2623 0.231300331466535 3759 6433346 An anti-infammatory.
SGTC_1571 st070080 73.4 µM -0.736711059803157 0.231369828507317 no 2624 0.230649039825125 3785 4315245
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.737255039720208 0.23121007309208 no 2625 0.230483634036066 3747 6708739 YPR165W RHO1
SGTC_1999 st074831 12.5 µM -0.737477944878304 0.231144628334054 no 2626 0.230415875315058 3720 17112523
SGTC_3280 9140961 49.47 µM -0.738172730277165 0.230940706290683 no 2627 0.23020474588405 3754 4901226
SGTC_2523 spermine 47.74 µM -0.739708805606105 0.230490219297501 no 2628 0.229738351941311 3708 1103 A DNA binding polyamine.
SGTC_2364 9055074 200 µM -0.740257244962479 0.230329496778195 no 2629 0.229571959228671 3753 6470630
SGTC_1756 st041558 35.5 µM -0.740409256979471 0.230284960095576 no 2630 0.229525851786056 3789 3955792
SGTC_2426 5582046 32.21 µM -0.740988141051429 0.230115401969307 no 2631 0.229350315388389 3730 2251934
SGTC_739 1486-1183 203 µM -0.741289166236277 0.230027257754373 no 2632 0.229259064553219 3705 4346692
SGTC_2050 5263056 171 µM -0.741353810357986 0.230008331552454 no 2633 0.229239471406097 3763 763468 YGL055W OLE1
SGTC_2665 lovastatin 100 µM -0.743491658940621 0.229382913486016 no 2634 0.228592034795574 3764 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1318 1280-3875 124 µM -0.744544827126152 0.22907516463144 no 2635 0.228273466113868 3753 373245
SGTC_2910 7948405 25.97 µM -0.744666497254357 0.229039626035896 no 2636 0.22823667868478 3681 2971328
SGTC_2973 9094665 17.96 µM -0.745068713749464 0.228922164742636 no 2637 0.228115090709441 3786 25237061 YIL048W NEO1
SGTC_2696 st077691 74.316 µM -0.747250259246108 0.228285666348966 no 2638 0.227456255634675 3735 757133
SGTC_2139 5578692 56.4705 µM -0.747890049609169 0.228099186796689 no 2639 0.22726323994942 3685 650991 YMR113W FOL3
SGTC_2566 crystal violet carbinol 226 nM -0.748458818471793 0.227933479815535 no 2640 0.227091727971931 3739 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2303 7774051 200 µM -0.750187180396737 0.227430349007494 no 2641 0.22657098930954 3721 2953184
SGTC_2741 miltefosine 3.04 µM -0.751544910325878 0.227035549306394 no 2642 0.226162391656436 3706 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1764 st044502 93.5 µM -0.751651013329341 0.227004713041441 no 2643 0.226130478381304 3788 8407
SGTC_1928 4'-methoxychalcone 40.3 µM -0.752912090707885 0.22663839237897 no 2644 0.225751371047286 3808 641818
SGTC_949 1165-0505 146 µM -0.753076650842157 0.226590615193896 no 2645 0.225701927217849 3800 6244267
SGTC_928 2764-0428 58.7 µM -0.754501475622251 0.226177179793622 no 2646 0.225274079822898 3808 662578
SGTC_507 nimesulide 162 µM -0.755304520427537 0.225944351617853 no 2647 0.225033143495532 3785 4495 A COX2 inhibitor.
SGTC_770 0389-1121 67.2 µM -0.756567451004924 0.225578462244594 no 2648 0.224654523903728 3868 6753108
SGTC_846 0335-0850 148 µM -0.756833423038043 0.225501449040701 no 2649 0.224574833047293 3774 6819598
SGTC_23 0213-0011 39.996 µM -0.757968215707333 0.225173032803781 no 2650 0.22423500536025 3786 627608
SGTC_1297 1068-0111 14.1 µM -0.758700525159059 0.224961241699722 no 2651 0.224015861344139 3720 767057
SGTC_419 nsc-638432 893 µM -0.759289784310809 0.224790904159083 no 2652 0.223839613587895 3745 368090
SGTC_2300 7976697 71.57 µM -0.759296458740372 0.224788975196191 no 2653 0.223837617713621 3702 2236109
SGTC_1644 st010134 20.9 µM -0.759789404108612 0.224646536036182 no 2654 0.223690238775077 3762 3818134
SGTC_1047 2043-3044 82 µM -0.760087743587482 0.224560354147456 no 2655 0.223601069174911 3776 669592
SGTC_3085 9117376 49.47 µM -0.760137392435509 0.224546013811728 no 2656 0.223586231773771 3866 16480349
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.760933290878078 0.224316201249476 no 2657 0.223348456489074 3767 688662
SGTC_3259 9138485 49.47 µM -0.761259721905678 0.224221984192663 no 2658 0.223250976589598 3860 17646153
SGTC_1790 st045711 43.5 µM -0.762093748098213 0.223981363156116 no 2659 0.223002026971736 3759 585119
SGTC_1240 0356-0016 42.1 µM -0.763978152737147 0.223438242859617 no 2660 0.222440131026039 3774 4305613
SGTC_653 0203-0016 55.2 µM -0.76569948196243 0.222942779391789 no 2661 0.221927567690949 3814 295302
SGTC_1674 st016616 23.6 µM -0.766247487192504 0.222785174252064 no 2662 0.221764528826773 3776 625830
SGTC_2871 9038510 12.99 µM -0.766549494757185 0.222698344661335 no 2663 0.221674706802229 3755 4945164
SGTC_3261 9137475 49.47 µM -0.767386123226546 0.222457908038099 no 2664 0.221425988302681 3679 17027690
SGTC_134 0269-0018 6.916 µM -0.768815998379464 0.222047322614168 no 2665 0.221001275056704 3728 4378915
SGTC_2493 resveratrol 26.09 µM -0.768895273388802 0.222024571638607 no 2666 0.220977741792684 3682 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1036 k216-0215 33.5 µM -0.769603856141475 0.221821276017678 no 2667 0.220767458451731 3780 622330
SGTC_2955 9076254 12.21 µM -0.770418380442382 0.221587716697944 no 2668 0.22052587688721 3738 16459619
SGTC_3100 9120536 49.47 µM -0.771249154535614 0.221349642708358 no 2669 0.220279631877386 3646 16421196
SGTC_3271 9137798 49.47 µM -0.77269360069601 0.220936057860516 no 2670 0.219851867392653 3696 6498326
SGTC_186 3455-3465 67.277 µM -0.772856901309802 0.220889328231114 no 2671 0.219803536863685 3736 755278
SGTC_821 1114-0266 29.2 µM -0.774328552095331 0.2204684602657 no 2672 0.219368261604716 3808 3123235
SGTC_2341 7987486 176.74 µM -0.77539897196064 0.220162626669498 no 2673 0.219051971207271 3803 1258686
SGTC_1470 k295-0292 231 µM -0.776473212485242 0.219855946224365 no 2674 0.218734815691315 3842 5045612
SGTC_958 1222-0007 33 µM -0.776807784869863 0.219760480647651 no 2675 0.218636091552359 3863 7312461
SGTC_1345 1488-0192 31.4 µM -0.778346488718942 0.219321739413251 no 2676 0.218182388002659 3800 658348
SGTC_1068 loratadine 26.9 µM -0.78016960176953 0.218802554762513 no 2677 0.217645526233582 3841 3957 A H1 histamine antagonist.
SGTC_1563 conessine 56.1 µM -0.780421296540502 0.218730932929213 no 2678 0.217571468268473 3859 441082 An anti-amoebic, histamine inhibitor.
SGTC_2487 5918373 44.05 µM -0.780622198972651 0.218673774161326 no 2679 0.217512365737735 3809 2876279
SGTC_779 1360-0071 233 µM -0.781714815342303 0.218363064351746 no 2680 0.217191096420054 3882 7566
SGTC_1873 rapamycin 2 nM -0.78247629857998 0.218146670087733 no 2681 0.216967354580068 3782 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_101 0490-5701 117.494 µM -0.784147756830583 0.217672117574318 no 2682 0.216476707896296 3670 4661669
SGTC_2570 licareol 100 µM -0.784211544665483 0.217654019041663 no 2683 0.216457996082072 3831 443158
SGTC_1319 1306-0155 43.7 µM -0.785257748586477 0.217357303368171 no 2684 0.216151231446175 3846 3122360
SGTC_1421 4029-0249 71.4 µM -0.786032085515898 0.217137842846673 no 2685 0.215924345017611 3878 2894095
SGTC_2638 epoxomicin 18 µM -0.786048279395508 0.217133254587247 no 2686 0.215919601565085 3820 9915668 A protesome inhibitor.
SGTC_2373 9071805 200 µM -0.786099301405458 0.217118798737726 no 2687 0.215904656777656 3782 10149009
SGTC_2228 7354201 200 µM -0.787552757436382 0.216707230804044 no 2688 0.215479178752451 3827 753451
SGTC_2342 7990637 118.86 µM -0.788010766826694 0.216577632108776 no 2689 0.215345204036143 3886 2033102 YER133W GLC7
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.789174873130995 0.216248437559967 no 2690 0.21500490284614 3786 390807
SGTC_315 k915-0449 187 µM -0.790327586193645 0.215922750519918 no 2691 0.214668240135223 3847 20970215 YNL149C PGA2
SGTC_2460 5552655 174.22 µM -0.791762385229171 0.215517760353617 no 2692 0.214249619366526 3820 5401989
SGTC_1393 3470-5649 58.2 µM -0.7926971845006 0.215254138632705 no 2693 0.213977135539903 3786 4108395
SGTC_2701 st077767 14.721 µM -0.794098375240255 0.214859341056308 no 2694 0.213569081710559 3819 5721188
SGTC_3320 9137005 35.139 µM -0.795904189482747 0.214351158197855 no 2695 0.213043862998498 3850 4908713
SGTC_2358 9037157 4 µM -0.797675857087078 0.213853264732498 no 2696 0.212529308857629 3847 2388925
SGTC_1875 nocodazole 6 µM -0.800227842109731 0.213137262842193 no 2697 0.21178940066444 3794 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2605 digitonin 300 nM -0.800796749386406 0.212977837244299 no 2698 0.211624660584859 3845 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1276 0871-0068 94.2 µM -0.801252611255602 0.21285014073358 no 2699 0.211492709532329 3827 3414906
SGTC_2625 euphol 100 µM -0.802697468812811 0.212445701104288 no 2700 0.211074808151901 3842 6708538 A triterpene alcohol.
SGTC_815 1582-0027 36.9 µM -0.802726656375348 0.212437535649912 no 2701 0.211066371117968 3887 3128206
SGTC_142 0335-0849 62.6745 µM -0.803718721840174 0.212160106441006 no 2702 0.210779719614022 3853 3889043 YPR107C YTH1
SGTC_2015 5119600 184 µM -0.80714997749999 0.21120219704919 no 2703 0.209790040658281 3864 2828786
SGTC_2306 7482397 179.52 µM -0.808707347248949 0.210768261017515 no 2704 0.209341750503878 3818 891448
SGTC_697 0508-1955 564 µM -0.808800820236865 0.210742232919029 no 2705 0.209314862173489 3805 6243113
SGTC_391 gliotoxin 8.33 µM -0.811478173436142 0.209997509071373 no 2706 0.208545561154319 3942 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1059 3448-6867 171 µM -0.811762683460111 0.20991846168861 no 2707 0.208463909172415 3787 3934407
SGTC_201 4262-0159 12.803 µM -0.813673180250312 0.209388108344955 no 2708 0.207916101214599 3867 1341029
SGTC_1088 bifonazole 369 nM -0.814174093453247 0.209249185564461 no 2709 0.20777261220295 3789 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1019 4262-0212 3.4 µM -0.815735388136764 0.208816525861233 no 2710 0.207325747219165 3895 4677213
SGTC_159 3970-0959 50 µM -0.816015275570184 0.208739020336869 no 2711 0.207245699520847 3925 6615653
SGTC_1228 0124-0032 52.5 µM -0.817003523282215 0.208465493616984 no 2712 0.206963207292323 3937 X1228
SGTC_1652 st011932 78 µM -0.818931820451965 0.207932389449003 no 2713 0.20641265691914 3778 1551076
SGTC_294 k038-0071 157 µM -0.820015196919448 0.207633228678103 no 2714 0.206103721938223 3864 24152826
SGTC_501 nsc-95397 161 µM -0.820355306393285 0.207539364205251 no 2715 0.206006793099355 3881 262093
SGTC_1113 artemisinin 1.17947 µM -0.820983713334314 0.207366000485256 no 2716 0.205827772623223 3870 2240 An anti-malaria and mitochondrial poison.
SGTC_382 3229-0966 23.2 µM -0.821010578371877 0.207358590918294 no 2717 0.205820121373229 3873 5722370
SGTC_1841 st054148 70 µM -0.821905064221669 0.207111974790449 no 2718 0.205565465258949 3912 675442
SGTC_3086 9117350 49.47 µM -0.823572130636372 0.206652815985893 no 2719 0.205091358392777 3774 2679265
SGTC_873 0591-4978 488 µM -0.824485035925921 0.206401630838763 no 2720 0.204832007474262 3914 3305145
SGTC_920 mycophenolic acid 780.421 nM -0.826860464607084 0.205748881959628 no 2721 0.204158077072423 3911 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1426 4048-4480 71.7 µM -0.827487098457917 0.2055768923916 no 2722 0.203980515820739 3839 14224343
SGTC_37 0566-0070 1.56 µM -0.82885357671163 0.205202136951856 no 2723 0.203593633533388 3875 1626686
SGTC_1310 1188-0297 994 nM -0.828958887123777 0.205173272521999 no 2724 0.203563835839892 3788 1588352
SGTC_2916 7875993 68.79 µM -0.830553857606817 0.204736403640167 no 2725 0.203112855329594 3798 1299250
SGTC_2226 7298446 200 µM -0.830633654290528 0.204714561548026 no 2726 0.203090308365676 3849 3283010
SGTC_181 1447-1644 8.07 µM -0.830786685099954 0.204672677557136 no 2727 0.203047072903449 3881 534600
SGTC_1396 3511-0007 98.6 µM -0.831286954651318 0.204535791128825 no 2728 0.20290577118922 3881 X1396
SGTC_132 0417-1715 25.805 µM -0.835534451367775 0.203375764920785 no 2729 0.201708428903399 3841 6769098
SGTC_1392 3455-1037 33.9 µM -0.836224673383802 0.203187631092456 no 2730 0.2015142601881 3888 981132
SGTC_2083 5306046 65.942 µM -0.837049936216353 0.202962825598438 no 2731 0.201282249743868 3912 539837
SGTC_3109 9122853 49.47 µM -0.837093550367753 0.202950949031628 no 2732 0.201269992726907 3942 1234709
SGTC_1607 st000305 50.6 µM -0.837355493754925 0.202879627977162 no 2733 0.20119638739874 3887 5457690
SGTC_800 3448-7362 155 µM -0.837513416468843 0.20283663655263 no 2734 0.201152019376323 3956 15991913
SGTC_217 ketoconazole 989 nM -0.839302178066985 0.202350060622634 no 2735 0.200649880652036 3781 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3124 9127567 49.47 µM -0.840935254631075 0.201906444026244 no 2736 0.200192103415476 3858 17592030
SGTC_978 1416-0512 87.4 µM -0.840937271736396 0.201905896450532 no 2737 0.200191538377286 3955 6814003
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.841092713986492 0.201863701823422 no 2738 0.200147998264857 3889 2724 A muscle relaxant with antifungal properties.
SGTC_1339 1486-1321 22.7 µM -0.841165979271577 0.201843815873451 no 2739 0.200127478284274 3907 3469382
SGTC_2752 diclazuril 33.15 µM -0.841219752830739 0.20182922119029 no 2740 0.200112418308273 3888 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_425 3825-7017 13.1 µM -0.843579533028936 0.201189375650978 no 2741 0.199452202622972 3990 3397440
SGTC_12 0849-0099 9.267 µM -0.843873294770351 0.201109808478802 no 2742 0.199370106288328 3789 6071388
SGTC_356 1634-0012 32.5 µM -0.846152037417081 0.200493238276666 no 2743 0.198733967155899 3866 735457
SGTC_1030 k029-0042 36.7 µM -0.847440658366972 0.200145073071813 no 2744 0.198374775066175 3893 6080581
SGTC_1074 carmofur 3.8 µM -0.848894165850832 0.199752794533099 no 2745 0.197970092759446 3938 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3226 9131256 49.47 µM -0.849082150614261 0.199702094236437 no 2746 0.197917790899475 3790 17178073
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.854630744245994 0.198209103948549 no 2747 0.196377800923466 3706 88881 An O-methylated flavonoid and antioxidant.
SGTC_2611 pyromycin 23.93 µM -0.855226439380317 0.198049218515388 no 2748 0.196212900956231 3913 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1681 tripelennamine 100 µM -0.855831197693909 0.197886980206593 no 2749 0.196045578039314 3876 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1630 st005209 31.3 µM -0.85588246821007 0.197873229575274 no 2750 0.196031396630607 3850 3367314
SGTC_3210 9128157 49.47 µM -0.857345554739634 0.197481076531689 no 2751 0.195626969648891 3975 17590849
SGTC_1525 8-methoxypsoralen 92.5 µM -0.859471714559972 0.196912037407964 no 2752 0.195040159433075 3954 4114 Related to psoralen; DNA damaging agent.
SGTC_2519 cryptotanshinone 88.04 µM -0.860776278591041 0.196563379669828 no 2753 0.194680636131481 3882 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1236 0330-0013 258 µM -0.862348357191538 0.196143723305212 no 2754 0.194247924902218 3934 4617066
SGTC_2466 5983409 37.09 µM -0.864303273306295 0.195622629501994 no 2755 0.193710656247216 3936 2879657
SGTC_1404 3909-7820 48.3 µM -0.86477426746539 0.19549720913954 no 2756 0.193581348718013 3864 23741373
SGTC_224 benfluorex 43.875 µM -0.865059911222793 0.195421169265814 no 2757 0.193502953250672 3915 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3196 9111891 49.47 µM -0.865292149808614 0.195359359372948 no 2758 0.193439229208804 3913 18891510
SGTC_2220 6782180 200 µM -0.868591345613285 0.194482567502855 no 2759 0.192535344896242 3823 833803
SGTC_2888 9058547 12.99 µM -0.868842919981353 0.194415807711314 no 2760 0.192466526893281 3841 16476514
SGTC_2060 5238662 140 µM -0.869053130851087 0.194360035169443 no 2761 0.192409035382438 3922 790130
SGTC_3083 9117465 49.47 µM -0.869204130394679 0.19431997841838 no 2762 0.192367744323227 3904 16420915
SGTC_3251 9135047 49.47 µM -0.869766906884477 0.194170730875969 no 2763 0.192213899957268 3934 17682963
SGTC_611 3453-1652 23.7 µM -0.870104300513561 0.194081288040584 no 2764 0.192121703862286 3902 1560575
SGTC_1329 1447-1697 50.6 µM -0.870345936245764 0.194017245990405 no 2765 0.192055691175921 3946 2840515
SGTC_1293 1000-1278 195 µM -0.871966721140096 0.193588013355262 no 2766 0.191613266343642 3984 678847
SGTC_592 k241-0073 46.5 µM -0.872044132230888 0.193567527069217 no 2767 0.191592151109085 3926 4230158
SGTC_2393 9031399 185.94 µM -0.872593292681843 0.193422233686962 no 2768 0.191442398875106 3981 1526623 YDL150W RPC53
SGTC_168 3970-0862 530.542 µM -0.873404625282487 0.193207698267512 no 2769 0.191221285417882 3916 3135186
SGTC_435 c-PAF 6.7 µM -0.876312358531564 0.192440019002695 no 2770 0.190430124171634 3949 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_180 1486-1293 102.781 µM -0.877483039508975 0.192131471357328 no 2771 0.190112163545865 3851 4140536
SGTC_3303 9125618 40.5795 µM -0.877876764295208 0.192027768308378 no 2772 0.190005300014425 3975 22695467
SGTC_3009 9080819 71.4286 µM -0.878648751378446 0.191824534319823 no 2773 0.189795876927826 3954 17027216
SGTC_781 4335-2806 94.4 µM -0.879337415422735 0.191643347206382 no 2774 0.189609177386264 4042 845254
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.879830481907328 0.191513686110828 no 2775 0.189475574545342 3995 61125 An anti-inflammatory.
SGTC_2221 6807166 181.081 µM -0.881084828251024 0.191184074529428 no 2776 0.189135954158327 3871 674925
SGTC_1292 0kpi-0043 232 µM -0.882676335399731 0.190766366266235 no 2777 0.188705585794705 3970 3333905
SGTC_351 caspofungin 25 nM -0.883276272628163 0.190609051708751 no 2778 0.188543510190785 3951 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1390 3413-2614 145 µM -0.883421740375452 0.190570919393239 no 2779 0.188504224390924 3988 3421432
SGTC_1251 0490-5699 265 µM -0.884161779616161 0.190377001082532 no 2780 0.188304443596606 3996 3883818
SGTC_1089 terbinafine 2.25 µM -0.884229730155201 0.190359201544392 no 2781 0.188286106237249 3951 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_745 0469-0705 296 µM -0.884747359885422 0.190223642793509 no 2782 0.188146453114783 4034 3486736
SGTC_3323 9138564 53.9225 µM -0.885808527979491 0.189945925723696 no 2783 0.18786035680731 3972 43912313 YNL103W MET4
SGTC_1043 0916-0009 19.3 µM -0.885869104725937 0.18993007977763 no 2784 0.187844033118403 3974 3101130
SGTC_2828 7998861 71.43 µM -0.886500778564264 0.189764892031992 no 2785 0.187673867401056 3896 2988188
SGTC_8 0354-0001 70 µM -0.886917311819555 0.189656013619685 no 2786 0.187561710218524 3948 4993152
SGTC_2491 paeonol 100 µM -0.888270419910142 0.189302587394773 no 2787 0.187197653553087 3811 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1446 4239-0190 62 µM -0.889724385142582 0.188923269930431 no 2788 0.186806948473345 3971 1340085
SGTC_3236 9132701 49.47 µM -0.890471488120629 0.188728544360473 no 2789 0.186606385691392 3958 24282524
SGTC_1913 st060213 96.1 µM -0.891790980461072 0.188384933045536 no 2790 0.186252488530657 4006 688959
SGTC_894 0960-0238 55.9 µM -0.892728790540827 0.188140951029019 no 2791 0.186001214257928 3917 6741907 YDL195W SEC31
SGTC_2096 5468907 200 µM -0.892997757957401 0.188071012081083 no 2792 0.185929186663811 4006 759785
SGTC_2395 5646831 180.19 µM -0.893351629995683 0.187979020038663 no 2793 0.185834448556198 3987 6808628
SGTC_2222 6885208 172.143 µM -0.893558936873561 0.187925141760606 no 2794 0.185778962569777 3889 609514
SGTC_2757 clomiphene 4.22 µM -0.893683926742871 0.187892661971386 no 2795 0.185745513816204 4034 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3029 9088683 49.47 µM -0.894268774579279 0.187740729839144 no 2796 0.185589051324622 3983 25236615
SGTC_2436 5633522 8.09 µM -0.896000556803571 0.187291291587397 no 2797 0.185126232924973 3938 5724242
SGTC_2499 avocadenofuran 51.48 µM -0.896410467821732 0.187185007471601 no 2798 0.185016789317918 3946 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3076 9116187 49.47 µM -0.897760493072546 0.186835228851463 no 2799 0.184656625546749 3960 27241210
SGTC_2999 9069765 71.4286 µM -0.899763251772874 0.18631707896029 no 2800 0.184123127269128 3979 2097066
SGTC_1979 st071809 45.3 µM -0.899978451247103 0.186261455986267 no 2801 0.184065859207659 4064 4976333
SGTC_3166 9102297 49.47 µM -0.900044358179494 0.186244422967795 no 2802 0.184048322525088 3993 25237072
SGTC_1655 st012546 55.1 µM -0.900810131093181 0.186046587022536 no 2803 0.183844640002621 3955 720985 YLR208W SEC13
SGTC_571 k831-0106 44.2 µM -0.901367496801506 0.185902674624908 no 2804 0.183696478556492 3862 4783639
SGTC_2549 cedrol 20.94 µM -0.903152674506409 0.185442204719923 no 2805 0.183222435547025 3898 6708665 A sedative which affects the nervous system.
SGTC_2829 7992743 58.44 µM -0.905963719016847 0.184718558658808 no 2806 0.182477528049376 4010 16462845
SGTC_1152 3909-8331 15.9 µM -0.909720940726333 0.183754084193112 no 2807 0.181484848828321 3952 16001939
SGTC_1548 st061468 90.8 µM -0.91001365414571 0.183679076949408 no 2808 0.181407654479216 3967 390799
SGTC_1496 4469-0713 57.4 µM -0.910453503062081 0.183566402397304 no 2809 0.181291696233259 3933 746691
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.911023622220394 0.183420421091242 no 2810 0.181141463674021 3988 7104
SGTC_3131 9127911 49.47 µM -0.912273355048647 0.183100675256182 no 2811 0.180812418501958 4041 45595681
SGTC_2236 dapsone 200 µM -0.913027783030836 0.182907822252615 no 2812 0.18061396481559 3982 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2905 7799065 20.05 µM -0.913037244338593 0.182905404481482 no 2813 0.180611476868532 3897 1296806
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.913060402699246 0.182899486608284 no 2814 0.180605387232858 3986 689007
SGTC_1946 st076057 65.1 µM -0.914539701226092 0.182521715210948 no 2815 0.180216663275581 3887 953009
SGTC_3048 9093155 49.47 µM -0.918267941674962 0.181571790953618 no 2816 0.179239303270944 3930 25236002
SGTC_1736 st036774 51 µM -0.9183436987392 0.181552520821619 no 2817 0.179219478139963 4073 1272247
SGTC_3290 9121031 71.43 µM -0.919748011695186 0.181195541110514 no 2818 0.178852228338333 4010 17014854
SGTC_387 norethindrone acetate 66.7 µM -0.921722836507697 0.180694280324126 no 2819 0.178336582818502 4003 541197
SGTC_51 1013-0126 23.419 µM -0.922267438664389 0.180556199532777 no 2820 0.178194546968797 3982 1627850
SGTC_2802 7925815 54.55 µM -0.922376345337801 0.180528594805087 no 2821 0.178166151944224 3965 1262923
SGTC_1114 scopoletin 1.73284 µM -0.922958426278586 0.180381098818005 no 2822 0.178014435478192 4022 5280460 A coumarin with genotoxic properties.
SGTC_3183 9108214 49.47 µM -0.924287853098184 0.18004451329045 no 2823 0.177668232664693 3939 4974831
SGTC_1952 st077036 64.1 µM -0.924805321624722 0.179913606811109 no 2824 0.177533590991889 4009 2937007
SGTC_1183 1254-0324 198 µM -0.927403743959104 0.179257175566941 no 2825 0.176858473748775 4084 5799357
SGTC_3061 glucosamine 200 µM -0.928220516007972 0.179051148553056 no 2826 0.176646597190111 3875 91431 and experimental redox chemotherapeutic
SGTC_1387 3342-1166 1.8 µM -0.929285875088752 0.178782640594367 no 2827 0.176370476681026 3986 3418228
SGTC_1262 0737-0114 49.6 µM -0.930374562377028 0.1785085151208 no 2828 0.176088592221487 4082 765919
SGTC_1334 1486-0610 236 µM -0.931457689192939 0.178236052614794 no 2829 0.175808430677204 4096 3742339
SGTC_988 1497-1057 103 µM -0.931462158783654 0.178234928824463 no 2830 0.175807275158297 3926 3533044
SGTC_961 1252-1571 372 µM -0.931724250073973 0.178169038953225 no 2831 0.175739525365829 4020 6813498
SGTC_2805 7950783 58.44 µM -0.935478623091265 0.17722687359382 no 2832 0.174770847470087 4035 1178958 YDL195W SEC31
SGTC_2913 7966556 36.57 µM -0.93598130208195 0.177100964853611 no 2833 0.174641407404382 3869 2976516
SGTC_2037 5169046 200 µM -0.937382558518104 0.176750282937234 no 2834 0.174280904683213 4078 5718022
SGTC_2204 7233102 200 µM -0.93849528271155 0.17647212274584 no 2835 0.173994970039241 3911 2172480
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.939795269206058 0.176147501418834 no 2836 0.173661292962774 4068 688798
SGTC_1322 1348-1070 12 µM -0.940459113313181 0.175981877923442 no 2837 0.173491056361731 3985 6758089
SGTC_1742 st038235 28.8875 µM -0.941714687324209 0.175668892538517 no 2838 0.173169366696381 4073 564103 YBR002C RER2
SGTC_2891 9063876 19.48 µM -0.943856502456315 0.175135802401741 no 2839 0.172621491209364 4014 6472478
SGTC_1451 4152-0210 104 µM -0.945071579399582 0.174833830772778 no 2840 0.172311166878421 4037 659563
SGTC_2302 7771753 200 µM -0.945739696082896 0.174667930921319 no 2841 0.17214068510525 4035 2203047
SGTC_1170 0310-0127 64.8 µM -0.948172172712865 0.174064768125398 no 2842 0.171520905538643 4040 774975
SGTC_859 0439-0102 54.6 µM -0.949574049110203 0.173717757620401 no 2843 0.171164364884447 4034 610143
SGTC_1373 2887-0003 58.5 µM -0.952860812727648 0.17290590238677 no 2844 0.170330298680691 4007 776948
SGTC_1884 5633444 25 µM -0.95508865831338 0.17235698489837 no 2845 0.169766431999543 4047 5724239
SGTC_649 1123-0311 367 µM -0.958246092087716 0.171580933248361 no 2846 0.168969340020977 3947 693629 YIL048W NEO1
SGTC_1294 1000-1494 117 µM -0.958765103607862 0.171453581695779 no 2847 0.168838546349446 4028 712797 YDL207W GLE1
SGTC_935 2996-0153 430 µM -0.958952003669709 0.171407736214885 no 2848 0.168791462471462 4072 23738523
SGTC_1500 4488-1866 171 µM -0.95992716879348 0.171168661080621 no 2849 0.168545935668526 4102 2900003
SGTC_608 k048-0125 159 µM -0.961146951509738 0.170869914918099 no 2850 0.168239142512856 4091 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2262 9014885 67.46 µM -0.961704747059838 0.170733412249114 no 2851 0.168098968565631 3991 6457424
SGTC_1193 1488-0126 41.5 µM -0.964593299678375 0.170027648112444 no 2852 0.167374278366018 4018 1384710
SGTC_1267 0828-0272 9.49 µM -0.964605135678321 0.170024760058129 no 2853 0.167371313056637 4134 745334
SGTC_2166 5933061 31.504 µM -0.964872913078842 0.169959429184151 no 2854 0.167304235010155 4145 2877375
SGTC_2742 clothiapine 36.27 µM -0.96506739825934 0.169911989837114 no 2855 0.167255527475523 4011 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_345 1362-0200 395 µM -0.965412706057228 0.169827782351822 no 2856 0.167169069931372 4041 1419823
SGTC_1560 lithocholic acid 53.1 µM -0.967910049040145 0.169219571849967 no 2857 0.16654464758336 3915 9903 A bile acid which acts as a detergent.
SGTC_2629 bisabolol 100 µM -0.968732640969128 0.169019541867773 no 2858 0.166339301124551 4090 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1212 0520-0165 585 µM -0.969382121953595 0.168861714672651 no 2859 0.166177284504976 4213 5403258
SGTC_2453 5731132 22.18 µM -0.97009014307167 0.168689769835294 no 2860 0.166000780899598 4096 1362040
SGTC_937 3122-0005 46.7 µM -0.971059815809744 0.168454464853642 no 2861 0.165759246428515 4094 759535
SGTC_417 st075190 100 µM -0.971793880492532 0.168276473973022 no 2862 0.165576550431444 4060 222757
SGTC_3262 9137218 49.47 µM -0.972653867558925 0.168068104250944 no 2863 0.165362680253771 3920 17650664
SGTC_380 3970-0968 6 µM -0.973413613129149 0.167884160638757 no 2864 0.165173887903209 3952 2891601
SGTC_1241 0364-0022 50.8 µM -0.975127519167906 0.167469679358799 no 2865 0.164748504805047 4089 4563895
SGTC_2997 9067075 71.4286 µM -0.977303994137673 0.166944284106755 no 2866 0.16420933814984 4084 27209819
SGTC_266 formosanin C 406 nM -0.981239638784951 0.165996932377902 no 2867 0.163237290557619 3961 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1680 diphenhydramine 100 µM -0.981640709922512 0.165900585694646 no 2868 0.163138442107477 4063 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_285 1486-1325 46 µM -0.981653530807736 0.165897506413926 no 2869 0.163135282899261 4112 22310230
SGTC_1009 4106-0057 9.87 µM -0.982539217299749 0.165684874383757 no 2870 0.162917136179426 4066 2928005
SGTC_1445 4239-0156 97.7 µM -0.983747412383181 0.16539510008126 no 2871 0.16261986079355 4163 4008346
SGTC_1432 4049-0298 68.4 µM -0.984906001206918 0.165117531538978 no 2872 0.16233512265538 4092 741646
SGTC_3001 9076041 71.4286 µM -0.987835046890647 0.164417152009609 no 2873 0.161616720156407 4060 16004211
SGTC_190 3970-0790 3.722 µM -0.988942888842546 0.164152752770716 no 2874 0.161345542462208 3971 2832352
SGTC_3159 9100096 49.47 µM -0.989064945117144 0.164123639509548 no 2875 0.161315683671324 4017 25236875
SGTC_911 3456-4043 236 µM -0.98937661904904 0.164049313221477 no 2876 0.161239454810641 4103 914281
SGTC_2162 5663267 200 µM -0.990249086333554 0.163841368149512 no 2877 0.161026192720043 4069 6456493
SGTC_223 busulfan 5 mM -0.990395648592151 0.16380645308519 no 2878 0.160990385749492 4079 2478 A DNA alkylator.
SGTC_2539 epi(13)torulosol 80 µM -0.993064844744095 0.163171423836971 no 2879 0.160339177384438 4118 6708597
SGTC_53 0973-0023 39.979 µM -0.99335945103881 0.163101432129956 no 2880 0.160267407413812 3943 674768
SGTC_1508 1080-0625 72.9 µM -0.995822841739758 0.162516950792659 no 2881 0.159668114967353 3947 767111
SGTC_63 0099-0242 26.702 µM -0.997107754836346 0.162212624831197 no 2882 0.159356104640268 4121 3898502 YLR359W ADE13
SGTC_612 0302-0167 22.4 µM -0.998027646423392 0.16199498064614 no 2883 0.159132976409762 4093 235821
SGTC_292 k038-0015 474 µM -0.99840877575372 0.161904862099859 no 2884 0.159040589949357 4088 46368540
SGTC_52 0329-0193 875 nM -1.00213819598536 0.161024759480871 no 2885 0.158138426230104 4200 3739292
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.00378281136772 0.160637642029098 no 2886 0.157741655579587 4065 442882
SGTC_1259 0671-0132 43 µM -1.00435120482324 0.160503992309809 no 2887 0.157604680354483 4009 X1259
SGTC_219 mitoxanthrone 164.414 µM -1.00481583769497 0.160394794409323 no 2888 0.157492768112337 4044 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_897 1000-0139 31.4 µM -1.00685942902385 0.159915086543063 no 2889 0.157001165451209 4045 6151020
SGTC_112 phenothiazine 287.218 µM -1.00759866876476 0.159741790485248 no 2890 0.156823584144571 4022 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3247 9135149 49.47 µM -1.00827182140164 0.159584093803205 no 2891 0.15666199340455 4093 8934436 YOR116C RPO31
SGTC_3102 9121669 49.47 µM -1.01037766511975 0.159091424672329 no 2892 0.156157192181737 4129 41905072
SGTC_1499 4480-0877 67.3 µM -1.01127008471207 0.158882941071119 no 2893 0.155943589976448 4036 2861909
SGTC_991 3996-0057 64.7 µM -1.01397995763927 0.158250968945499 no 2894 0.155296157968999 4173 715343
SGTC_3186 9110464 49.47 µM -1.01597671351723 0.157786360502329 no 2895 0.154820237840673 4119 17018021
SGTC_1361 1608-0041 5.61 µM -1.01618173110917 0.157738707438839 no 2896 0.154771427179112 4076 X1361
SGTC_644 1498-1197 63.3 µM -1.01634707461966 0.157700282868657 no 2897 0.154732069543869 4144 6741615
SGTC_999 SEC7.066 22.7 µM -1.01770178288185 0.157385690595206 no 2898 0.154409849869797 4071 740511 YDR170C SEC7
SGTC_127 0180-0333 59.125 µM -1.01815531698978 0.15728046249301 no 2899 0.154302075197729 3978 771601
SGTC_1501 4491-0275 38.4 µM -1.01843812060035 0.15721487036812 no 2900 0.154234896912132 4076 5104718
SGTC_3038 9091290 49.47 µM -1.02029233890011 0.156785257421409 no 2901 0.153794917814208 4141 25236843
SGTC_1909 st060837 51.5 µM -1.02192496668849 0.156407626071032 no 2902 0.153408207385418 4099 678937
SGTC_1907 st060210 83.7 µM -1.02419979334904 0.155882451933006 no 2903 0.152870458177349 4155 688793
SGTC_623 k072-0108 16.9 µM -1.0306413128073 0.154401654612898 no 2904 0.151354527559666 4085 5382803
SGTC_1758 st042942 75.2445 µM -1.03090095310852 0.154342163291643 no 2905 0.151293634809726 4066 669317
SGTC_2191 5911152 200 µM -1.03150875072319 0.154202958042919 no 2906 0.151151153376168 4125 2875902
SGTC_150 3970-0969 77.2 µM -1.03199722300271 0.154091142347844 no 2907 0.151036709209326 4207 6615640
SGTC_1141 3253-0389 52.6 µM -1.03237391775292 0.154004950173956 no 2908 0.15094849278878 4127 5402031
SGTC_1232 0279-0259 161 µM -1.03509718231955 0.153382784382315 no 2909 0.150311764165156 4123 1560000
SGTC_686 1319-0111 510 µM -1.0375906991604 0.152814569772685 no 2910 0.149730324922268 4190 4562600
SGTC_2458 5808907 16.39 µM -1.03946258241199 0.152388929514668 no 2911 0.149294825715031 4275 2731747
SGTC_2879 9041815 71.43 µM -1.04007197209535 0.152250532706501 no 2912 0.149153232054518 4139 4942971
SGTC_1994 st072947 40.9 µM -1.04013938155033 0.152235228658736 no 2913 0.149137574761013 4178 5286565 YDL195W SEC31
SGTC_1412 3909-8563 178 µM -1.04161894113472 0.1518995797341 no 2914 0.14879419173965 4214 23767530
SGTC_1647 st011722 22.4 µM -1.04311313069972 0.151561111221248 no 2915 0.148447949986266 4112 2854783
SGTC_1666 st014829 29 µM -1.04329913032244 0.151519013120013 no 2916 0.148404886881317 4115 3858230
SGTC_3142 9086498 49.47 µM -1.04374085654588 0.151419066465431 no 2917 0.148302650789394 4039 25236367
SGTC_200 k038-0079 37.545 µM -1.04375838884721 0.151415100445025 no 2918 0.148298593967837 4100 3436683
SGTC_2786 7743617 45.45 µM -1.04429455045473 0.15129384750678 no 2919 0.148174566698504 4100 583674
SGTC_2937 9044753 11.33 µM -1.04633814661045 0.150832280614885 no 2920 0.147702469588955 4081 6465530 YGL099W LSG1
SGTC_845 0330-0138 4.51 µM -1.04820668974393 0.150411072475301 no 2921 0.147271694527304 4105 9039800
SGTC_2820 7989630 71.43 µM -1.05049844305786 0.149895535049876 no 2922 0.146744503202678 4153 2984098
SGTC_110 0850-0284 111.64 µM -1.05053081476947 0.149888261377752 no 2923 0.146737065545402 3944 3906265
SGTC_667 1498-1044 59 µM -1.0537496316304 0.149166193520734 no 2924 0.145998779662443 4160 6739982
SGTC_1409 3909-8004 61.9 µM -1.05612997142741 0.14863371539684 no 2925 0.145454419533615 4161 2119279
SGTC_1231 0242-0792 125 µM -1.0574149676753 0.148346792626614 no 2926 0.145161121718679 4137 3707635
SGTC_1722 st034304 3.6505 µM -1.05790786411655 0.148236833704915 no 2927 0.145048724777172 4141 4036148 YLR033W RSC58
SGTC_995 3931-2021 34.6 µM -1.05891867584914 0.148011505090921 no 2928 0.144818409041908 4147 730143
SGTC_689 0833-0039 98 µM -1.06053803844173 0.147650997299241 no 2929 0.144449947156627 4105 5374726
SGTC_108 0509-0257 621.132 µM -1.06121028265343 0.147501512988163 no 2930 0.144297173697984 4113 536624
SGTC_1143 3454-2408 5.08 µM -1.0654653912202 0.146557673764047 no 2931 0.143332689504951 4148 X1143
SGTC_1948 st076329 66.6 µM -1.06555931816008 0.146536885358266 no 2932 0.143311448777974 4027 24208413
SGTC_185 k048-0037 25.491 µM -1.06708898378671 0.146198610271677 no 2933 0.142965827940581 4206 6827589
SGTC_1637 st007924 17.4 µM -1.06806371585416 0.14598332873969 no 2934 0.142745885809414 4086 683336
SGTC_3065 9113888 49.47 µM -1.06841108781274 0.145906658888017 no 2935 0.142667558836388 4237 16648368
SGTC_2388 9080168 200 µM -1.07220306710548 0.145071476023353 no 2936 0.14181441655345 4150 15943073
SGTC_843 0310-0051 143 µM -1.0730567429459 0.144883898663544 no 2937 0.141622828874273 4201 2065037
SGTC_2738 aclarubicin 5.55 µM -1.07352469163275 0.144781146076876 no 2938 0.14151788311559 4134 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.07476490851022 0.144509055595938 no 2939 0.141239997521933 4231 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1744 st037937 38.9 µM -1.07607324578198 0.144222393889686 no 2940 0.140947249942514 4246 1016152
SGTC_2812 7970281 58.44 µM -1.07758673743735 0.143891260611772 no 2941 0.140609111744564 4210 2233435
SGTC_722 3534-0461 190 µM -1.07772016681327 0.143862092532216 no 2942 0.140579327924237 4226 658262
SGTC_824 1304-0008 100 µM -1.07854777405105 0.14368126409783 no 2943 0.140394686862491 4194 768245
SGTC_3179 9107801 49.47 µM -1.08054961565957 0.143244505216973 no 2944 0.139948752557805 4166 4818259
SGTC_759 3486-0358 89.3 µM -1.0809324522676 0.143161080731553 no 2945 0.139863580862505 4171 875103
SGTC_1713 st033146 12.748 µM -1.08316367081504 0.142675525736439 no 2946 0.139367890904046 4176 674619
SGTC_325 2810-4341 181 µM -1.08382187483686 0.1425325011289 no 2947 0.139221892144943 4167 774970
SGTC_279 1273-0055 2.93 µM -1.08610861626244 0.142036356891933 no 2948 0.138715470385756 4190 2847562
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.09016608849385 0.141158905479236 no 2949 0.137819994225154 4185 5106787 A p450 inhibitor.
SGTC_109 0132-0036 33.701 µM -1.09180428356445 0.140805680222195 no 2950 0.137459567924975 3989 67274 A color developer.
SGTC_1950 st077106 7.18 µM -1.09505635185638 0.140106252178494 no 2951 0.136745974695364 4136 13831864
SGTC_2027 5150920 200 µM -1.09589611940427 0.139926026003192 no 2952 0.136562118757217 4137 786715
SGTC_2918 7977171 22.06 µM -1.10047012923604 0.1389471446548 no 2953 0.13556366875054 4178 2236483
SGTC_1226 3909-7979 35.4 µM -1.10086393213838 0.138863085636346 no 2954 0.135477940874431 4181 6615510
SGTC_2348 9022543 33.42 µM -1.10141000353733 0.138746581528569 no 2955 0.135359126797455 4231 3162678 YDL140C RPO21
SGTC_2725 haloperidol 53.21 µM -1.10147817437012 0.138732041985231 no 2956 0.135344299220897 4126 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1000 4048-0884 8.67 µM -1.10149931488444 0.138727533326034 no 2957 0.135339701254817 4239 13040088
SGTC_636 0kpi-0074 126 µM -1.10219361584021 0.138579514510857 no 2958 0.135188753440756 4201 616434
SGTC_73 0327-0325 16.231 µM -1.10367825385386 0.138263363988093 no 2959 0.134866366047148 4057 53298
SGTC_1546 5-methoxyflavanone 78.7 µM -1.10393183714134 0.138209413167197 no 2960 0.13481135351605 4196 147795
SGTC_2382 9035899 200 µM -1.10577535822826 0.137817628429755 no 2961 0.134411881618762 4194 6462679
SGTC_2185 6113692 200 µM -1.10915873662614 0.137100566614987 no 2962 0.13368085493693 4215 874150
SGTC_940 3232-1287 54.8 µM -1.11328031792217 0.136230501894454 no 2963 0.132794028408108 4180 1585493 YIL048W NEO1
SGTC_3260 9137109 49.47 µM -1.11422290700142 0.136032053622968 no 2964 0.132591785280189 4152 17478346
SGTC_3157 9099274 49.47 µM -1.11592956348168 0.135673245928148 no 2965 0.132226143009888 4241 17217662
SGTC_973 1325-0077 65.9 µM -1.11958945884773 0.134905976422651 no 2966 0.131444374806845 4210 2835149
SGTC_2927 9011802 47.9 µM -1.12340936664346 0.134108341741412 no 2967 0.130631836775286 4225 43912568
SGTC_1277 0873-0036 22 µM -1.12350723341646 0.134087948843233 no 2968 0.130611065120937 4284 5965735
SGTC_2767 sibutramine 71.45 µM -1.12951277208678 0.132840625443789 no 2969 0.129340792381256 4248 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1643 st009866 20.2 µM -1.13019033162352 0.132700402579837 no 2970 0.129198016429099 4169 3156273 YOR207C RET1
SGTC_3162 9099653 49.47 µM -1.13155272256093 0.132418760595787 no 2971 0.128911262986829 4187 25237511
SGTC_2090 5301565 104.445 µM -1.13323493010886 0.132071572814334 no 2972 0.128557804572865 4227 2056344
SGTC_1414 3917-0015 5.4 µM -1.1357633877461 0.131550910696316 no 2973 0.128027801852795 4219 6618702
SGTC_2014 4013930 200 µM -1.1358814275377 0.131526638506196 no 2974 0.128003096078816 4199 64556
SGTC_822 1487-0950 154 µM -1.13666283035637 0.131366038809743 no 2975 0.127839631701882 4239 1958375
SGTC_789 1309-1135 70.6 µM -1.14002713885366 0.130676127935675 no 2976 0.127137497415619 4207 3092424
SGTC_1306 1185-0270 9.02 µM -1.14049111625405 0.130581178088243 no 2977 0.127040875858442 4264 1548076
SGTC_1336 1486-0901 104 µM -1.1483584015681 0.128978450977147 no 2978 0.125410319447484 4263 5006114
SGTC_1200 1643-0193 18.4 µM -1.15145881790052 0.128350595725897 no 2979 0.124771764088877 4265 5403974
SGTC_1025 k007-0731 70 µM -1.15168687756466 0.128304496032257 no 2980 0.124724883264251 4207 6256118
SGTC_2863 9028737 58.44 µM -1.15382144060376 0.12787357549552 no 2981 0.124286691035393 4225 6460917
SGTC_329 k048-0121 21.3 µM -1.15457092676822 0.127722509827276 no 2982 0.124133089023786 4253 6832902
SGTC_2919 7978188 46.38 µM -1.15637051834816 0.127360292625426 no 2983 0.123764817598585 4267 2980291
SGTC_2763 lisinopril 49.32 µM -1.15785949384136 0.127061136059916 no 2984 0.12346068995198 4144 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1570 verbenone 133 µM -1.16029853512643 0.126572154891706 no 2985 0.122963640363794 4271 29025 A natural terpanoid with antifungal properties.
SGTC_939 1165-0479 45.3 µM -1.16439871810731 0.125753103350794 no 2986 0.122131233426159 4251 1377347
SGTC_1561 5-methoxyflavone 52.9 µM -1.1663969822355 0.125355273492459 no 2987 0.121726989045156 4204 94525
SGTC_812 4251-0442 148 µM -1.16675540158382 0.125284009627969 no 2988 0.121654581165545 4281 5723007
SGTC_749 1000-0129 128 µM -1.16730669799579 0.125174451589493 no 2989 0.12154326735294 4307 708470
SGTC_711 k292-0785 179 µM -1.1678195533511 0.12507259294864 no 2990 0.121439779577761 4171 4146315
SGTC_2603 homopterocarpin 100 µM -1.16790293991248 0.125056036945365 no 2991 0.121422959072674 4243 101795 A weak amylase inhibitor.
SGTC_2456 5770359 74.46 µM -1.16830055893766 0.12497711263971 no 2992 0.121342774996446 4274 3118787
SGTC_1211 1056-0033 32.3 µM -1.1683580212777 0.124965709687196 no 2993 0.121331190188509 4312 6741922
SGTC_834 0312-0008 75.7 µM -1.16881592902252 0.124874867444407 no 2994 0.121238900589899 4269 6385573 YIL048W NEO1
SGTC_1634 st006576 41 µM -1.1704151867933 0.124557959947879 no 2995 0.1209169635054 4234 3915356
SGTC_794 k038-0031 316 µM -1.1713815338981 0.124366742195084 no 2996 0.120722725723678 4253 6624242
SGTC_3024 9090631 49.47 µM -1.17277778713824 0.12409081870487 no 2997 0.120442464025551 4232 25236383
SGTC_129 0088-0017 176.636 µM -1.17279180881219 0.124088049956587 no 2998 0.120439651863368 4146 182446
SGTC_841 0251-0215 91.2 µM -1.17321924755461 0.124003667774225 no 2999 0.120353947694391 4298 3888614
SGTC_249 wiskostatin 11.211 µM -1.17532938745578 0.123587686099959 no 3000 0.119931480845791 4247 2775510 A n-wasp and actin depolymerizer.
SGTC_2289 7946404 165.07 µM -1.18205864665097 0.122267647128646 no 3001 0.118591215691097 4266 1246120 YPR165W RHO1
SGTC_1731 st035964 63 µM -1.18352114684048 0.121982071259689 no 3002 0.118301335344146 4194 6739575
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.18356287047869 0.121973930950371 no 3003 0.118293072709876 4249 756377
SGTC_210 3551-0445 56.827 µM -1.1843850051271 0.12181360976139 no 3004 0.118130346593019 4313 2865180 YOR207C RET1
SGTC_1527 coumarin 137 µM -1.18568589963093 0.121560230098667 no 3005 0.117873182501306 4346 323 A hepatotoxic, DNA x-linker.
SGTC_2586 curcumin 80 µM -1.18570075276165 0.121557339244258 no 3006 0.117870248586035 4181 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_328 k915-0120 63.5 µM -1.18646165759837 0.121409309510048 no 3007 0.117720017382591 4265 6624543
SGTC_212 3807-4682 38.772 µM -1.18678940068983 0.121345588012342 no 3008 0.117655350355813 4338 3125501 YBL034C STU1
SGTC_1556 plumbagin 1.48 µM -1.18780108020763 0.121149040419691 no 3009 0.11745589436632 4199 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_632 0781-2353 4.65 µM -1.1879238324309 0.121125207542556 no 3010 0.117431709653346 4347 6811515 YHR007C ERG11
SGTC_1794 st048918 76.9 µM -1.18814972033528 0.121081359044065 no 3011 0.117387214304895 4198 672303
SGTC_3234 9132280 49.47 µM -1.19127888516343 0.120475086073199 no 3012 0.116772060088301 4302 17612295
SGTC_2245 6637752 200 µM -1.19288795883094 0.120164163132689 no 3013 0.116456627813097 4325 681890
SGTC_607 4491-0986 66.8 µM -1.19407211154949 0.119935709558114 no 3014 0.116224880644523 4299 698981 YDR232W HEM1
SGTC_618 k072-0232 33.2 µM -1.19546979998253 0.119666453622689 no 3015 0.115951764343656 4325 5872756 YGL099W LSG1
SGTC_713 1488-1073 324 µM -1.19679258069838 0.119412021115986 no 3016 0.11569370540876 4294 3312542
SGTC_1799 st045822 46.1415 µM -1.19946325575478 0.118899489441345 no 3017 0.11517393203777 4269 3674992
SGTC_2596 sinensetin 100 µM -1.20032039784395 0.118735324336669 no 3018 0.115007465388373 4292 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_840 0245-0196 390 µM -1.20112003939508 0.118582316520576 no 3019 0.114852320332594 4372 3827528
SGTC_3298 9116858 71.43 µM -1.20286667967073 0.118248589437101 no 3020 0.114513958144449 4353 2506942
SGTC_2255 7941087 197.44 µM -1.20418976060505 0.117996233429385 no 3021 0.11425812134264 4403 935561
SGTC_1656 st012921 11 µM -1.2052569470997 0.117792962843169 no 3022 0.114052062179206 4189 6732821
SGTC_2551 apiole 73.87 µM -1.20633515167546 0.11758784537952 no 3023 0.113844144560086 4191 10659 A possible DNA adduct former.
SGTC_1621 st003705 32.4 µM -1.20646800722054 0.11756258847024 no 3024 0.113818543814067 4294 24207032
SGTC_1837 st055472 66.5 µM -1.20659486353621 0.117538475647326 no 3025 0.113794102925563 4356 676091
SGTC_2476 5806916 10.51 µM -1.20711936880321 0.117438814959354 no 3026 0.113693088342586 4180 2870194
SGTC_767 0929-0023 86 µM -1.21075935310216 0.116748833744167 no 3027 0.112993823764873 4314 1204563
SGTC_766 1391-0721 126 µM -1.22042534836789 0.114930548951862 no 3028 0.111151836492061 4329 1020919 YIL115C NUP159
SGTC_2657 nystatin 74.44 µM -1.22070738177097 0.114877799357751 no 3029 0.111098415923161 4339 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1055 3448-0672 86 µM -1.22291014374421 0.114466402322757 no 3030 0.110681818420442 4286 748378
SGTC_1520 flindersine 88 µM -1.22888485215756 0.11335582402128 no 3031 0.109557490815521 4364 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_757 1066-0008 322 µM -1.23056592777249 0.113044735848301 no 3032 0.109242627579161 4347 6842497
SGTC_1673 st016611 27.3 µM -1.23074947108186 0.11301080752684 no 3033 0.109208289567957 4312 5226799
SGTC_2492 derrusnin 100 µM -1.23192077209837 0.112794461527838 no 3034 0.108989340574656 4338 1715307 Part of coumarin class of compounds.
SGTC_130 0136-0219 337.655 µM -1.23231788579142 0.112721179522344 no 3035 0.108915180563626 4144 234244
SGTC_868 0527-0199 213 µM -1.2331233609309 0.112572644316188 no 3036 0.108764871476944 4273 2849450
SGTC_707 0865-0008 204 µM -1.23381469330347 0.112445269358836 no 3037 0.108635981484713 4347 723043
SGTC_620 0109-0052 432 µM -1.2379126255511 0.111692357141576 no 3038 0.10787423017358 4352 493037
SGTC_1751 st044839 27.194 µM -1.23893662975421 0.111504781552924 no 3039 0.107684483550182 4350 5291326
SGTC_657 3534-0529 86.7 µM -1.24184795386728 0.110972721278957 no 3040 0.107146332966374 4360 1049549
SGTC_874 0599-0792 117 µM -1.24203085219269 0.110939356431809 no 3041 0.107112589556787 4327 765305
SGTC_1100 amiodarone 5.07 µM -1.24688026799378 0.110057331526777 no 3042 0.106220701429221 4376 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1781 st038725 66.3 µM -1.24815274022035 0.109826726370259 no 3043 0.105987563625125 4315 4270275 YIL048W NEO1
SGTC_1245 0418-0076 17.2 µM -1.25193747805836 0.109142883443963 no 3044 0.105296323466814 4348 6790114
SGTC_3297 9117502 71.43 µM -1.25609559093092 0.108395110979074 no 3045 0.104540657255839 4362 7453720
SGTC_453 enantio-paf c16 10 µM -1.25909668848523 0.10785770513409 no 3046 0.103997705204979 4047 13871343 A lipid and platelet activating factor
SGTC_1079 idarubicin 2.36 µM -1.25992044587791 0.107710531310045 no 3047 0.103849031110023 4346 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2661 dactinomycin 12.96 µM -1.26188678202386 0.107359807502294 no 3048 0.103494764464438 4296 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1565 sinapyl alcohol 95.1 µM -1.26638015429248 0.106561442900797 no 3049 0.102688506280947 4345 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1648 st011736 69.8 µM -1.26734505310116 0.106390563907936 no 3050 0.102515968834061 4328 2855514
SGTC_2175 5807670 165.306 µM -1.26974044162674 0.105967207517055 no 3051 0.102088551037213 4301 241186
SGTC_228 caffeine 993.056 µM -1.27295828710082 0.105400409673794 no 3052 0.101516422067938 4341 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.27416732248606 0.105188015507315 no 3053 0.101302061710054 4405 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2354 9060492 162 µM -1.28079830156284 0.104028641437178 no 3054 0.100132260388089 4380 6471895
SGTC_1221 2958-7315 257 µM -1.28116251885637 0.103965230446727 no 3055 0.100068294066836 4370 4562705
SGTC_443 clozapine 122 µM -1.28121214533336 0.10395659254385 no 3056 0.100059580637141 4320 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2205 7238770 200 µM -1.28160505309566 0.103888222037367 no 3057 0.0999906133457314 4412 279867
SGTC_1288 0973-0013 65.5 µM -1.28295350770116 0.103653823340105 no 3058 0.0997541824621543 4392 4315430
SGTC_2256 7954252 200 µM -1.28301941065738 0.103642377427327 no 3059 0.0997426378639531 4354 2972920
SGTC_2964 9083345 53.42 µM -1.28314041609246 0.10362136379809 no 3060 0.0997214431905033 4328 17741579
SGTC_696 1560-0013 611 µM -1.28479524019388 0.103334299610196 no 3061 0.0994319230547987 4399 1650269
SGTC_3125 9127534 49.47 µM -1.28693192231036 0.102964501552173 no 3062 0.0990590088018624 4248 1639235
SGTC_1134 3477-0009 42.5 µM -1.29003698403754 0.102428820015339 no 3063 0.098518908690886 4410 3973534
SGTC_448 monastrol 171 µM -1.29029701223541 0.102384052390583 no 3064 0.0984737769356656 4284 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2681 menadione 3.18 µM -1.29152446409798 0.102172920854435 no 3065 0.0982609388139674 4391 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3269 9137823 49.47 µM -1.29176707253085 0.102131227778249 no 3066 0.098218910823781 4283 17682936
SGTC_1997 st073024 93.8 µM -1.29377834965413 0.101786059601122 no 3067 0.0978709965454959 4389 686268
SGTC_2431 5490079 200 µM -1.29514848140727 0.101551409282123 no 3068 0.0976345065423739 4398 5722345
SGTC_2744 captopril 92.04 µM -1.296216567131 0.101368761144345 no 3069 0.0974504416853764 4422 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_188 3229-0966 278.469 µM -1.29900072249017 0.100893781489229 no 3070 0.0969718406138756 4403 5722370
SGTC_1103 duloxetine 36.1 µM -1.2994492313801 0.100817417434279 no 3071 0.0968949028214319 4442 60835 A selective serotonin reuptake inhibitor.
SGTC_386 1509-0011 3.07 µM -1.29967295584824 0.100779341400505 no 3072 0.0968565415961185 4374 3107280
SGTC_2377 9073351 62.6 µM -1.30247337361087 0.100303620610644 no 3073 0.0963773071680236 4355 7337946 YHR072W ERG7
SGTC_57 miconazole 162.5 nM -1.30247630472805 0.100303123547398 no 3074 0.0963768064815849 4216 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_879 0831-1030 162 µM -1.30410343681247 0.10002746948234 no 3075 0.096099158630791 4370 1549252
SGTC_1746 st038117 42 µM -1.30431373831127 0.0999918825031939 no 3076 0.0960633165136703 4409 2898218
SGTC_703 3875-0075 71.8 µM -1.30550415415728 0.0997906159718466 no 3077 0.0958606167667729 4416 2850814
SGTC_1362 1611-0397 101 µM -1.30589584475168 0.099724456631449 no 3078 0.0957939899297198 4337 27816
SGTC_666 0272-0154 136 µM -1.30948919920976 0.0991190083602032 no 3079 0.0951843470044016 4368 6870312
SGTC_680 0417-1641 114 µM -1.31013306674233 0.0990108070172638 no 3080 0.0950754119484945 4378 2835990
SGTC_3044 9093193 49.47 µM -1.31046372184594 0.0989552743235973 no 3081 0.0950195045693223 4391 25236277
SGTC_2124 5246320 200 µM -1.3105235232874 0.0989452332554531 no 3082 0.0950093958892813 4391 579342
SGTC_1779 st039427 55 µM -1.31224222961328 0.098656969271219 no 3083 0.0947192087038517 4364 1124498
SGTC_2902 5787006 60.46 µM -1.3130251875743 0.0985258543861458 no 3084 0.0945872304898252 4331 591003
SGTC_2533 agelasine 13.65 µM -1.31589083818866 0.0980470577515777 no 3085 0.0941053421264823 4437 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1879 gemcitabine 100 µM -1.31719670363135 0.0978294384111558 no 3086 0.0938863492847859 4341 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1714 st033236 13.627 µM -1.31723653308878 0.0978228064962862 no 3087 0.0938796758250123 4399 2916566
SGTC_1017 4239-0030 168 µM -1.31891835413133 0.097543070869218 no 3088 0.0935982046852556 4390 1149593
SGTC_1925 st057770 10.1 µM -1.31958031035763 0.0974331293901536 no 3089 0.0934875901491108 4375 5989122
SGTC_2610 ononetin 44.17 µM -1.32051813822941 0.0972775252170349 no 3090 0.0933310421066686 4352 259632
SGTC_1002 4049-0206 172 µM -1.32243818214708 0.0969595209196564 no 3091 0.093011140760176 4343 4662749
SGTC_27 0485-0001 32.618 µM -1.32279027591393 0.0969012888357971 no 3092 0.0929525659470254 4373 2054479
SGTC_2225 6654152 15.4 µM -1.3245282356431 0.0966142273054905 no 3093 0.0926638360081944 4299 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_560 2332-1943 155 µM -1.32475738731568 0.0965764246251638 no 3094 0.0926258162381248 4374 21177716
SGTC_2472 5377652 49.4 µM -1.32501041609152 0.0965346956125853 no 3095 0.0925838482973023 4442 1610903
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.32675608261928 0.0962471645791972 no 3096 0.0922946912104351 4277 4000243
SGTC_84 0443-0269 128.823 µM -1.32739491897546 0.0961420984923109 no 3097 0.0921890397977544 4308 6150058
SGTC_3333 9141820 12.094 µM -1.32925239621186 0.0958370879308444 no 3098 0.091882356924183 4379 1939433
SGTC_1795 st049545 62.3 µM -1.32935948891734 0.095819524296786 no 3099 0.0918646982134356 4336 5291882
SGTC_2116 5511452 16.8835 µM -1.34661963283998 0.0930196421508077 no 3100 0.0890513838779542 4412 870744
SGTC_2983 9022671 12.99 µM -1.34672295232246 0.0930030660748477 no 3101 0.0890347386154551 4388 6405161
SGTC_64 000l-0018 272.079 µM -1.34678812290441 0.092992611546273 no 3102 0.0890242405143054 4317 6811119
SGTC_1483 3453-0561 55.9 µM -1.34914016865315 0.0926158825041733 no 3103 0.0886459741005003 4436 4546991
SGTC_1363 1636-0063 10.4 µM -1.34978876502015 0.0925121951574594 no 3104 0.088541874837057 4405 6072185
SGTC_984 1492-0255 2.91 µM -1.35045741512213 0.0924053918676765 no 3105 0.0884346523268584 4367 1585198
SGTC_2847 9005661 71.43 µM -1.35595667688881 0.0915304552955292 no 3106 0.0875564763547011 4447 2991449
SGTC_2748 diazoxide 86.69 µM -1.35741460409644 0.0912995309053586 no 3107 0.0873247552385958 4487 3019 A potassium channel activatior.
SGTC_1210 3013-0140 750 nM -1.3583039881335 0.0911588716361277 no 3108 0.0871836226644905 4428 905973
SGTC_2583 asiatic acid 100 µM -1.35908625482079 0.0910352862508368 no 3109 0.0870596289361353 4420 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2505 galangin 7.89 µM -1.3607646553562 0.0907705457673162 no 3110 0.0867940374129323 4306 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_370 0180-0345 38.7 µM -1.36156752049785 0.0906441089988645 no 3111 0.0866672056271721 4252 3989527
SGTC_1600 coumarin 106 71.1 µM -1.36398515854268 0.0902641641755883 no 3112 0.0862861183862265 4480 100336 A hepatotoxic, DNA x-linker.
SGTC_2524 avocatin b 10.57 µM -1.36428054434292 0.0902178239179022 no 3113 0.0862396433854154 4419 6710748
SGTC_2010 4012422 159 µM -1.37707590650103 0.0882274052685403 no 3114 0.0842443904311842 4369 952393
SGTC_25 0118-0223 35.662 µM -1.38572428139111 0.0869007412454321 no 3115 0.0829155554333889 4418 5333628
SGTC_446 go6976 132 µM -1.3857717914239 0.0868934945781406 no 3116 0.08290829925308 4448 3501 A protein kinase C inhibitor.
SGTC_2794 7785382 27.27 µM -1.38793689383301 0.0865637321297584 no 3117 0.0825781310916503 4420 2205081
SGTC_1531 st059297 52.4 µM -1.38834922939474 0.0865010363037252 no 3118 0.0825153641591867 4452 7566702
SGTC_2707 st078556 66.6 µM -1.39133517533947 0.0860480344337912 no 3119 0.0820619059950635 4362 17250899
SGTC_2795 7780010 54.55 µM -1.39539763833233 0.0854345660745552 no 3120 0.0814479815545674 4389 953673
SGTC_2646 retinol 96.75 µM -1.39892608860431 0.0849044016920486 no 3121 0.0809175741700041 4429 445354 A vitamin A analog and teratogen.
SGTC_2288 7946289 167.31 µM -1.4107043653601 0.0831525213827722 no 3122 0.0791659016366373 4464 1246052
SGTC_3017 9080681 49.47 µM -1.41185308927833 0.0829831277742691 no 3123 0.0789966113917564 4469 16451914
SGTC_3050 9093513 49.47 µM -1.4171297810369 0.0822083473922073 no 3124 0.0782224934533107 4402 25236664
SGTC_1833 st055984 71 µM -1.42233495616962 0.08144941850113 no 3125 0.0774645178180813 4464 676288
SGTC_133 0724-0033 378.92 µM -1.42386703924512 0.0812270462080036 no 3126 0.0772424823982616 4312 280309
SGTC_70 0141-0289 43.283 µM -1.42659676284196 0.0808319794520816 no 3127 0.0768480789216677 4407 352408
SGTC_2643 anethole 100 µM -1.42674214477239 0.0808109794138287 no 3128 0.0768271164686694 4449 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_819 1013-0258 27.7 µM -1.42763303727601 0.0806823822853182 no 3129 0.0766987546397627 4449 5753198
SGTC_428 3448-4153 16.5 µM -1.42768382657483 0.0806750556917787 no 3130 0.0766914417182994 4405 3834874
SGTC_2945 9067681 61.76 µM -1.43156288551763 0.0801169667363447 no 3131 0.0761344788834892 4500 16456930
SGTC_2557 derrustone 83.84 µM -1.4333927992675 0.0798547082178501 no 3132 0.075872807529417 4427 629853 An antioxidant.
SGTC_1157 4092-0394 27.6 µM -1.43505625898933 0.0796168692929697 no 3133 0.0756355333207441 4516 3659885
SGTC_1998 st075797 76.8 µM -1.43692941688849 0.0793496900410898 no 3134 0.0753690251484354 4438 24208315
SGTC_2576 guaiol 23.12 µM -1.43991267748968 0.0789255724559157 no 3135 0.0749460529502546 4356 227829
SGTC_2645 abamectin 100 µM -1.44217569920589 0.078604995233629 no 3136 0.0746264070690068 4411 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_732 3970-1727 52.7 µM -1.44376138980704 0.0783809567139768 no 3137 0.0744030531102998 4539 1275699
SGTC_2620 irigenin 100 µM -1.44470268943925 0.0782481918924497 no 3138 0.0742707070815484 4458 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3356 9151811 4.48 µM -1.44497311639459 0.0782100813030654 no 3139 0.0742327185157884 4479 1859254 YPR165W RHO1
SGTC_1853 st056710 91.2 µM -1.44863258095772 0.0776957455177411 no 3140 0.0737201087030572 4498 269167
SGTC_2648 atorvastatin 78.68 µM -1.44899524246207 0.0776449138084651 no 3141 0.0736694555995824 4466 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3063 1327-0034 4 µM -1.45286969067885 0.0771034343572381 no 3142 0.0731299688721578 4347 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_723 4182-0001 115 µM -1.45506761134572 0.0767975388860817 no 3143 0.0728252723375017 4475 744821 YLR208W SEC13
SGTC_1813 st051246 8.6015 µM -1.45926608618988 0.0762157823805204 no 3144 0.0722459429041727 4416 5291959
SGTC_1518 st038567 90.8 µM -1.46072507383711 0.07601440677494 no 3145 0.0720454525569175 4414 77966
SGTC_2816 7982706 58.44 µM -1.46155446342478 0.0759001116766158 no 3146 0.0719316702787987 4466 2981853
SGTC_870 0573-2213 57.6 µM -1.46985654206376 0.0747632341808582 no 3147 0.0708003058357979 4461 3916321
SGTC_3054 9094397 49.47 µM -1.47017177254476 0.0747203243177802 no 3148 0.0707576188232897 4471 2598354
SGTC_1848 st056003 16.4 µM -1.47251415809858 0.0744020621132955 no 3149 0.07044104330143 4482 146492
SGTC_34 0469-0683 81.75 µM -1.47772515852001 0.0736977519952312 no 3150 0.0697406787901182 4453 3690923
SGTC_2708 st078559 56 µM -1.47907624289707 0.0735159763595197 no 3151 0.069559969423341 4440 17250902
SGTC_2650 prasterone 100 µM -1.47960330159617 0.0734451586235019 no 3152 0.0694895724460873 4497 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1701 st028638 40.4 µM -1.48032038120157 0.0733488927028793 no 3153 0.0693938833047474 4496 3490878
SGTC_2048 5246248 200 µM -1.48108250039506 0.0732466861727185 no 3154 0.0692922952372226 4494 677046
SGTC_842 0271-0008 11.1 µM -1.48453319107716 0.0727852828485489 no 3155 0.0688337622681293 4505 1221709
SGTC_1184 1269-1718 139 µM -1.48583023894558 0.0726124268747353 no 3156 0.0686620147846639 4542 5403821
SGTC_3231 9132313 49.47 µM -1.48623934505708 0.0725579710804986 no 3157 0.068607911963191 4440 4905967
SGTC_416 estradiol valerate 100 µM -1.49066692545658 0.0719706189045413 no 3158 0.0680244818806362 4484 13791 A steroid.
SGTC_2619 obliquin 87.91 µM -1.5007760253651 0.0706432404542457 no 3159 0.0667067508148973 4471 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1695 st026914 34.495 µM -1.50271285890667 0.070391085342811 no 3160 0.0664565526654378 4482 3289191
SGTC_1825 st052143 62.6 µM -1.51319918199386 0.0690378772800121 no 3161 0.0651145359839506 4538 674173
SGTC_1623 st003709 20.3 µM -1.5136001479481 0.0689865353882464 no 3162 0.0650636417963743 4479 16192618
SGTC_2101 5377231 179.231 µM -1.5160430995311 0.068674362033255 no 3163 0.0647542273077232 4524 2844213
SGTC_3101 9120531 49.47 µM -1.52045425369744 0.06811344222108 no 3164 0.0641984238976046 4480 24824904
SGTC_849 0386-0493 241 µM -1.5217161661852 0.0679536305050643 no 3165 0.0640401075640434 4525 726119
SGTC_1187 1391-0724 117 µM -1.52334159128647 0.067748209489469 no 3166 0.0638366333712832 4560 6997986
SGTC_2032 5185112 25.99 µM -1.5306023225923 0.0668364514718849 no 3167 0.0629338536823817 4399 5718189
SGTC_3104 9120930 49.47 µM -1.53157395006779 0.0667151640925731 no 3168 0.062813802454056 4541 17014836
SGTC_3308 9128332 17.569 µM -1.53263364417585 0.0665830776898881 no 3169 0.0626830735067099 4476 17332805 YDL196W YDL196W
SGTC_1688 st021091 57.6 µM -1.5342664350293 0.0663799535352771 no 3170 0.0624820597967146 4542 3656366
SGTC_3336 9143619 71.43 µM -1.53979774362758 0.0656954065151857 no 3171 0.0618048310595689 4517 45595730
SGTC_418 lividomycin a 100 µM -1.5416684487757 0.0654651332184951 no 3172 0.0615770913952116 4538 72394 An antibiotic.
SGTC_3215 9129942 49.47 µM -1.54328831732143 0.0652662426409395 no 3173 0.0613804184609543 4492 17682944
SGTC_2041 5107442 45.335 µM -1.54362920227319 0.0652244478990695 no 3174 0.0613390931967348 4531 793005
SGTC_1793 st048256 72.231 µM -1.54480063486559 0.0650809808238437 no 3175 0.0611972468501664 4489 672022
SGTC_1889 st059080 5.18 µM -1.54968679247004 0.0644852057307512 no 3176 0.0606083548494891 4487 176925 Isolated from Daphnopsis sellowiana.
SGTC_1115 galangin 695.678 nM -1.55223358996498 0.0641763560004163 no 3177 0.0603031707944342 4584 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3177 9107506 49.47 µM -1.55427029388266 0.0639301936898249 no 3178 0.0600599781348715 4491 8897194
SGTC_3347 9188721 44.724 µM -1.55858576168441 0.0634110396657935 no 3179 0.0595472275804042 4524 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3316 9136639 10.545 µM -1.56338191723427 0.0628379151367524 no 3180 0.0589813954079514 4513 4903665
SGTC_2126 5251174 33.877 µM -1.56413979113246 0.062747722181806 no 3181 0.0588923715404974 4504 790722
SGTC_1521 st012942 49.4 µM -1.57280293291611 0.0617238939839834 no 3182 0.057882228166495 4446 24207259
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.57681148941825 0.0612545897322738 no 3183 0.0574194535887089 4532 803109
SGTC_2933 9026794 32.47 µM -1.58190952735944 0.0606617669396655 no 3184 0.0568351128294022 4477 17586027
SGTC_2791 5663188 71.43 µM -1.59190659941556 0.0595122998609234 no 3185 0.0557028462524009 4547 54690634
SGTC_2335 9018011 154.17 µM -1.59356830057987 0.0593229024059432 no 3186 0.0555163795832024 4521 6458208
SGTC_1524 corynanthine 62.1 µM -1.59675709587043 0.0589607736859245 no 3187 0.0551599315082718 4597 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_447 ml7 120 µM -1.59712904028636 0.0589186478021405 no 3188 0.0551184730335185 4597 4216 Selective myosin light chain kinase inhibitor.
SGTC_2496 diffractaic acid 79.83 µM -1.59768209245524 0.0588560535852905 no 3189 0.0550568730532728 4535 94870 An apoptosis inducer which activates caspases.
SGTC_278 4092-0821 23.9 µM -1.60050420633185 0.0585374600551924 no 3190 0.0547433872676748 4540 877900
SGTC_1509 1326-1131 80 µM -1.60202516449696 0.0583663187493612 no 3191 0.0545750224585216 4534 768313
SGTC_807 1315-0151 48 µM -1.60663913504796 0.0578495489734185 no 3192 0.0540667761976263 4540 4011080
SGTC_2365 9042475 200 µM -1.6149093132741 0.0569322886067914 no 3193 0.0531651675544335 4579 6464479
SGTC_3214 9129694 49.47 µM -1.61751824123486 0.0566453161135227 no 3194 0.0528832307043316 4547 17158655
SGTC_2545 solidagenone 89.61 µM -1.61911792523861 0.0564699211317515 no 3195 0.0527109463523066 4504 6708572 An anti ulcer agent
SGTC_2346 9031566 143.75 µM -1.62140566561989 0.0562198292838623 no 3196 0.0524653332471284 4541 4771086
SGTC_2272 7805186 180 µM -1.62490635162297 0.0558388317745067 no 3197 0.0520912573102985 4559 2956062 YPR165W RHO1
SGTC_590 k048-0076 22.4 µM -1.62520090122486 0.055806867578686 no 3198 0.0520598792401905 4576 6832814
SGTC_449 xestospongin c 11.1929 µM -1.6297774692839 0.0553120760866319 no 3199 0.0515742686510958 4583 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1970 st070122 35.8 µM -1.63051244538186 0.0552329386689996 no 3200 0.0514966185235594 4578 102928
SGTC_1453 4237-0541 195 µM -1.63761896881761 0.0544723597396366 no 3201 0.0507506017768015 4564 739892
SGTC_3064 1327-0027 10 µM -1.63981617535137 0.0542388866847464 no 3202 0.0505216969667671 4539 16000455 YPR107C YTH1
SGTC_2164 5685496 200 µM -1.63982946114332 0.0542374773614597 no 3203 0.0505203153598991 4496 759046
SGTC_1810 st050138 53 µM -1.64581977873087 0.0536049858618664 no 3204 0.049900434467672 4573 3444541
SGTC_569 4130-2812 160 µM -1.64767246513315 0.0534105562339346 no 3205 0.0497099506411751 4447 743552
SGTC_2216 7189485 200 µM -1.64870401995175 0.0533025424706236 no 3206 0.0496041431018422 4590 731273
SGTC_1973 st070275 50.2 µM -1.6524255478259 0.0529143009334116 no 3207 0.0492239155132548 4553 17118334
SGTC_2001 4023502 57.655 µM -1.6582923765347 0.0523068136969339 no 3208 0.0486292335016067 4550 108941 YCR052W RSC6
SGTC_189 3970-0742 2.116 µM -1.66348173681579 0.0517741033034182 no 3209 0.048108021828745 4552 2891807
SGTC_2788 5282734 71.43 µM -1.66565333750751 0.0515524628309285 no 3210 0.0478912405111447 4589 743706
SGTC_1702 st027038 51 µM -1.6663598681278 0.051480514952024 no 3211 0.0478208795172645 4602 5521182
SGTC_2120 5538279 151.968 µM -1.6698814396865 0.0511230941863575 no 3212 0.0474714115989298 4572 2058197
SGTC_395 anisomycin 6.25 µM -1.67148814990033 0.0509606790148171 no 3213 0.047312648707595 4583 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2543 pimpinellin 60.67 µM -1.67607879185569 0.0504988939759773 no 3214 0.0468613801436024 4450 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1579 chlormadinone acetate 49.4 µM -1.67641415483233 0.0504652900041001 no 3215 0.0468285491231749 4591 45114258 A steroidal progestin.
SGTC_508 roscovitine 141 µM -1.68137335267663 0.0499704462598254 no 3216 0.0463452090486393 4642 160355 A CDKinase inhibitor.
SGTC_3325 9138760 55.175 µM -1.6813989917024 0.0499678980113427 no 3217 0.0463427206301306 4523 43844959
SGTC_1289 0976-0073 69.1 µM -1.68271771867105 0.0498369701550519 no 3218 0.0462148749929345 4629 3391136
SGTC_1261 0712-0010 12.7 µM -1.68415283944862 0.0496947974074373 no 3219 0.0460760674007944 4568 2840123
SGTC_3004 9076122 71.4286 µM -1.69116279180083 0.0490049890075016 no 3220 0.0454028576257541 4575 44782551
SGTC_1359 1582-0056 520 nM -1.69139153167448 0.04898260958856 no 3221 0.0453810242960683 4625 3661189
SGTC_2857 9024691 58.44 µM -1.70010622934783 0.0481360467930287 no 3222 0.0445554728884701 4595 16478292
SGTC_1824 st053723 68.6 µM -1.71539796427158 0.0466789073534826 no 3223 0.043136144196338 4602 675225
SGTC_1405 3909-7894 12 µM -1.71570862021648 0.0466496760845691 no 3224 0.0431076931215311 4588 7104060
SGTC_2850 9015429 58.44 µM -1.7184083386628 0.0463962632540998 no 3225 0.042861080218036 4575 6457570
SGTC_2061 5245884 80.95 µM -1.72054689245324 0.0461963103401812 no 3226 0.0426665387613734 4575 573863
SGTC_810 3825-7150 143 µM -1.72898017961758 0.0454145416187179 no 3227 0.0419063212415397 4604 22330411 YGL099W LSG1
SGTC_2689 tacrolimus 100 µM -1.7305345028487 0.0452716232495414 no 3228 0.0417674111436259 4583 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_586 0957-0265 8.15 µM -1.74865400938317 0.0436321078239783 no 3229 0.0401754221670674 4530 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2121 5257820 149.641 µM -1.75114074304099 0.04341088643023 no 3230 0.0399608348069351 4617 791256
SGTC_2158 5657123 3.6195 µM -1.75470967182783 0.0430949755545791 no 3231 0.0396544904111659 4616 2858827
SGTC_287 k060-0039 29.6 µM -1.76083345932853 0.0425572453690203 no 3232 0.0391332974445959 4647 5861974
SGTC_860 0443-0016 25.1 µM -1.76685362651469 0.0420339157064637 no 3233 0.0386263725059731 4617 5337942
SGTC_2882 9058044 58.44 µM -1.76980349533324 0.0417793935206409 no 3234 0.0383799407092817 4622 18076804
SGTC_41 0478-0632 82.643 µM -1.77171439997363 0.0416151829633703 no 3235 0.0382209890368581 4582 3750424
SGTC_1506 4226-2149 212 µM -1.77808669598118 0.0410713652573731 no 3236 0.0376948085674423 4617 991114
SGTC_2112 5488546 200 µM -1.79080149822421 0.040003495537954 no 3237 0.036662577383193 4593 600757
SGTC_1255 0566-0045 221 µM -1.79219372256292 0.0398879508594845 no 3238 0.0365509699345328 4627 2788469
SGTC_777 1315-0167 517 µM -1.79562253297196 0.0396045405227939 no 3239 0.0362772848747608 4644 4221767
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.79720335445714 0.0394744294724093 no 3240 0.0361516711043874 4650 4174840
SGTC_1730 st033808 45.1 µM -1.8143265310466 0.0380872527081351 no 3241 0.0348137346421725 4560 1045166
SGTC_3201 9113999 49.47 µM -1.81464283096829 0.0380620076610534 no 3242 0.0347894079295789 4599 16649224
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.82304156619311 0.0373966520558978 no 3243 0.0341485478271656 4616 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_992 3909-8734 162 µM -1.82452041439223 0.0372804858301607 no 3244 0.0340367164754256 4642 4288319
SGTC_193 1273-0060 1.558 µM -1.82604409953058 0.0371611061014697 no 3245 0.0339218097005529 4518 2847393 YHR072W ERG7
SGTC_3091 9116372 49.47 µM -1.82880064885879 0.0369459261465936 no 3246 0.0337147388777821 4658 17169793
SGTC_2076 5212012 200 µM -1.82896238586049 0.0369333324408966 no 3247 0.0337026216377236 4620 604802
SGTC_2264 7948757 110.76 µM -1.83015615921107 0.0368404873918953 no 3248 0.0336132956472193 4593 2971411
SGTC_942 3253-1115 227 µM -1.83918355724345 0.0361445487617279 no 3249 0.0329440961523717 4646 46497897
SGTC_3155 9099265 49.47 µM -1.84434946185372 0.0357511665426341 no 3250 0.0325661137282927 4629 25236499
SGTC_2414 st077232 92.9 µM -1.84520679571308 0.0356862215145295 no 3251 0.0325037311664649 4577 729801
SGTC_2229 7354935 190 µM -1.84658160275977 0.0355822785664489 no 3252 0.0324039012772544 4628 318112
SGTC_1568 digitonin 820 nM -1.85226157458105 0.0351554692054616 no 3253 0.0319941353183775 4613 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2946 9065502 71.43 µM -1.85330392370821 0.0350776020904664 no 3254 0.0319194045544629 4549 16489101
SGTC_1975 st070967 30.8 µM -1.85366249755849 0.0350508481126681 no 3255 0.0318937301101972 4630 261391
SGTC_1044 1222-0021 1.78 µM -1.85692466012843 0.0348082193930421 no 3256 0.0316609367864858 4579 4306703
SGTC_474 dl-dihydrosphingosine 5 µM -1.87274371529751 0.0336511322215989 no 3257 0.0305518918109209 4620 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1704 st028805 70.8 µM -1.87893722120125 0.0332068157648182 no 3258 0.0301265328830695 4677 2876101
SGTC_2008 4012253 172 µM -1.90329415536786 0.0315060983673682 no 3259 0.028501086533609 4641 603940
SGTC_1142 3253-1408 9.78 µM -1.90695270192686 0.031256972131645 no 3260 0.0282633563076041 4655 256655
SGTC_338 4055-0136 114 µM -1.92314676929907 0.0301737366243782 no 3261 0.0272308100652442 4652 2900563
SGTC_2045 5106652 78.05 µM -1.92494471485441 0.0300554132400132 no 3262 0.02711813752297 4660 673349
SGTC_1490 4089-0339 670 nM -1.92509514669188 0.0300455307370013 no 3263 0.0271087280148814 4677 742542
SGTC_2390 9097792 176.6 µM -1.92961403165024 0.0297499199012865 no 3264 0.0268273394598999 4687 4497149
SGTC_2336 9001819 198.65 µM -1.94357076744377 0.0288521142916924 no 3265 0.0259736169154033 4643 2989602
SGTC_1498 4478-3555 97.6 µM -1.94400978377447 0.0288242427970893 no 3266 0.0259471356429452 4682 3437919
SGTC_1355 1499-0035 1.68 µM -1.95418803968947 0.0281843127561518 no 3267 0.0253394916238818 4680 1548538
SGTC_3027 9089541 49.47 µM -1.96369296046569 0.0275974394861121 no 3268 0.0247828547327841 4666 9943819
SGTC_1209 2323-2347 50.3 µM -1.96631134719607 0.0274375707390722 no 3269 0.0246313284327894 4677 5412760
SGTC_3136 9095672 49.47 µM -1.9690063582365 0.0272738308022364 no 3270 0.0244761804738385 4558 17217380
SGTC_541 4513-1321 94 µM -1.97969746966891 0.0266322836060027 no 3271 0.0238687665375061 4660 747515
SGTC_1967 st070177 51.4 µM -1.97980850361418 0.0266256874489825 no 3272 0.0238625252500006 4690 5729214
SGTC_3103 9120822 49.47 µM -1.98043397506209 0.0265885557639254 no 3273 0.023827392732181 4671 17141819
SGTC_746 1095-0025 46.6 µM -1.98219571165883 0.0264842011166374 no 3274 0.0237286702310807 4680 6749286
SGTC_691 1548-0686 185 µM -1.99162819020971 0.0259312828742554 no 3275 0.0232059339876337 4667 46495133
SGTC_67 0335-0847 266 µM -1.99574813819037 0.0256928256454681 no 3276 0.0229806722197264 4648 4552207 YOR254C SEC63
SGTC_367 0335-0881 7.1 µM -1.99645395729401 0.0256521584853368 no 3277 0.0229422663306241 4612 23828853
SGTC_2520 obtusaquinone 4.71 µM -2.00727244048206 0.025035543368599 no 3278 0.022360330982388 4693 5967872
SGTC_1148 3909-7663 27.7 µM -2.00937230204869 0.0249173101563071 no 3279 0.0222488326815651 4692 4084526
SGTC_2314 7727897 200 µM -2.01129557627602 0.0248094308915534 no 3280 0.0221471227451561 4651 900724
SGTC_1811 st050069 61.5 µM -2.01877829420874 0.0243934341805547 no 3281 0.0217551340320584 4685 3877702
SGTC_643 k048-0106 28.4 µM -2.03766199800007 0.023369575144951 no 3282 0.0207918735705995 4719 6763920
SGTC_3331 9141060 1.957 µM -2.05642603472605 0.0223882678243772 no 3283 0.0198707344820943 4673 4906567 YPR165W RHO1
SGTC_1365 1672-3266 55.4 µM -2.06655920286924 0.0218729403118418 no 3284 0.0193878542005651 4703 6415873
SGTC_1650 st011916 45.8 µM -2.07021573870673 0.0216894614392369 no 3285 0.0192160730280289 4691 242528
SGTC_4 0960-0234 25.671 µM -2.07071067747777 0.021664726437843 no 3286 0.0191929209020242 4649 6821112
SGTC_2768 sulfasalazine 50.2 µM -2.07183777469407 0.0216084876843931 no 3287 0.0191402862886337 4677 5384001 An antioxidant and salicylic acid derivative.
SGTC_2283 7944793 200 µM -2.09587204023797 0.0204382961939882 no 3288 0.0180467717940079 4674 2970533
SGTC_1291 0993-0025 5.79 µM -2.13518182765068 0.0186401931900103 no 3289 0.0163730803470525 4689 4353356
SGTC_3031 9088762 49.47 µM -2.14249821487488 0.018320838369246 no 3290 0.0160767060839982 4717 205253
SGTC_2069 5228469 200 µM -2.14946358968519 0.018021147970853 no 3291 0.0157988346785057 4702 2835210
SGTC_1507 4075-3230 155 µM -2.1596815249486 0.0175890822305112 no 3292 0.0153986661926576 4684 659771
SGTC_153 4077-0274 519.67 µM -2.16094184429055 0.0175364071904781 no 3293 0.0153499160152795 4701 3121976
SGTC_336 4111-0029 111 µM -2.17122742950749 0.0171115337061327 no 3294 0.0149569924454149 4729 3131175
SGTC_567 1080-0542 68.4 µM -2.17265838843012 0.0170531269749229 no 3295 0.0149030189091199 4649 5950415
SGTC_595 3909-8003 73.7 µM -2.18453866891048 0.0165747626785535 no 3296 0.0144613445239139 4755 699517
SGTC_1272 0839-0021 27 µM -2.19278714713861 0.0162494298326027 no 3297 0.0141613591996614 4762 5027250
SGTC_381 3461-2219 42.7 µM -2.21584450055554 0.0153688799627473 no 3298 0.013351076791741 4708 2883159
SGTC_3014 9081533 49.47 µM -2.22109206804951 0.0151743016274173 no 3299 0.0131723630860577 4726 21367265
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.22951624115494 0.0148663618393469 no 3300 0.0128897879552635 4737 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2253 7938677 135.83 µM -2.2404327230981 0.0144753225651335 no 3301 0.0125314219350117 4741 2301972
SGTC_32 0928-0142 34.1 µM -2.28172244824723 0.0130753167617488 no 3302 0.011252865942135 4750 2244242
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -2.28216424211018 0.0130609931652275 no 3303 0.0112398226735222 4742 94937 An inhibitor of serotonin biosynthesis.
SGTC_2860 9025725 38.96 µM -2.29258758757302 0.0127269663356538 no 3304 0.0109358798319717 4750 40546248
SGTC_1748 st037455 53.6035 µM -2.29733767861674 0.0125772130056182 no 3305 0.0107997569803791 4716 580690
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.30682750648951 0.0122825952903126 no 3306 0.0105322190846691 4748 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1717 st033143 58.0435 µM -2.31057704831791 0.0121678470969787 no 3307 0.0104281141026065 4723 674616
SGTC_1274 0865-0114 173 µM -2.31474989540563 0.0120412378999007 no 3308 0.0103133117138894 4750 870624
SGTC_2717 st081029 62.2815 µM -2.31621481335924 0.0119970622253533 no 3309 0.0102732713875168 4731 5292846
SGTC_2246 7293507 91.5585 µM -2.31666459740708 0.0119835268889494 no 3310 0.0102610047568325 4736 887656
SGTC_1633 st005664 67.9 µM -2.32088707497139 0.0118571044251668 no 3311 0.0101464696524777 4720 2063822
SGTC_182 3448-4371 550.524 µM -2.32290494490639 0.0117970983979748 no 3312 0.0100921297169399 4696 3491403
SGTC_2215 7188065 200 µM -2.3269847303658 0.0116765810917291 no 3313 0.00998303898320521 4760 940217
SGTC_3238 9133470 49.47 µM -2.35133750692689 0.0109791942447926 no 3314 0.0093530289539179 4753 3534688
SGTC_2843 9000894 45.46 µM -2.35705063907642 0.0108209358903555 no 3315 0.00921036734320785 4761 2242070
SGTC_2464 5717415 7.67 µM -2.36049153151817 0.0107265816148702 no 3316 0.00912536750532183 4724 5285744
SGTC_3 0833-0587 95.581 µM -2.3731938382375 0.0103844421324547 no 3317 0.00881750319208668 4663 5382644
SGTC_476 mead acid 10 µM -2.37594771156531 0.0103115334709336 no 3318 0.00875197152894606 4785 5312531 An omega 9 fatty acid.
SGTC_871 0574-0004 149 µM -2.39825992949522 0.00973709753855174 no 3319 0.00823658544850161 4722 9551173
SGTC_275 trichlorophene 5.69 µM -2.40236041492801 0.00963462600268267 no 3320 0.00814482503445216 4764 62616
SGTC_741 4582-0002 126 µM -2.44947504453661 0.00852317916093551 no 3321 0.00715323116199211 4771 2912688
SGTC_646 4092-0839 27.3 µM -2.45470947280399 0.00840692817484956 no 3322 0.00704992449947188 4755 877796
SGTC_2462 5162487 171.77 µM -2.45531764951123 0.00839351189912204 no 3323 0.00703800731742545 4746 2259986
SGTC_3289 9119912 71.43 µM -2.48588083392641 0.00774304871806472 no 3324 0.00646156156894265 4748 17014829
SGTC_3084 9116877 49.47 µM -2.49959373606438 0.00746591391738654 no 3325 0.00621679005946385 4746 27241325
SGTC_1826 st055655 41.6 µM -2.50281414509845 0.00740211138038865 no 3326 0.00616051132072348 4753 676168
SGTC_527 4476-4215 268 µM -2.51126489043261 0.00723696510021084 no 3327 0.00601496948973611 4758 4418754
SGTC_31 0508-1974 57.237 µM -2.56413690598629 0.00627556985292338 no 3328 0.00517163685599074 4752 6810525
SGTC_1028 k015-0029 4.8 µM -2.61354832456082 0.00548115875581829 no 3329 0.00448037053139126 4760 4588309
SGTC_1215 3852-0577 11.2 µM -2.67178519759501 0.00466055137617365 no 3330 0.00377244639774641 4788 2884876
SGTC_2111 5486399 200 µM -2.68543792875546 0.00448480625973989 no 3331 0.00362174138978978 4757 689674
SGTC_2647 atorvastatin 60.16 µM -2.70757207795241 0.004212434390621 no 3332 0.00338886756881396 4779 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1835 st008666 49.2 µM -2.71130813346709 0.00416794870832659 no 3333 0.00335091572947525 4764 690455
SGTC_3034 9090421 49.47 µM -2.74435896325675 0.0037923483481645 no 3334 0.00303146002773841 4762 17173761
SGTC_475 α-linolenic acid 10 µM -2.77038631516636 0.00351823558507707 no 3335 0.0027994920913631 4781 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2839 9003951 25.97 µM -2.77572622465686 0.00346424734751829 no 3336 0.0027539283224441 4783 2990634
SGTC_2846 9008642 19.48 µM -2.78521713584825 0.00337012510925869 no 3337 0.00267459444447067 4773 2992898
SGTC_895 0964-0006 13.7 µM -2.84023203186177 0.002868422874689 no 3338 0.00225403651040041 4775 6738897
SGTC_3286 9117135 37.221 µM -2.86273196277038 0.00268342365065242 no 3339 0.00210002850214947 4756 3438150
SGTC_1919 st067113 52.3 µM -2.93532753748018 0.00215766529870563 no 3340 0.00166597886742356 4764 1268243
SGTC_1686 st019653 115.5 µM -2.94949327865927 0.00206668747583451 no 3341 0.00159147748180302 4805 97252
SGTC_3253 9135987 49.47 µM -2.95407919681172 0.00203798950310481 no 3342 0.00156801757560378 4797 4182430
SGTC_2374 9071832 200 µM -2.96168953061965 0.00199116240540005 no 3343 0.00152978061791815 4785 17381698
SGTC_2407 paclitaxel 400 µM -2.97837091811423 0.00189192005389121 no 3344 0.00144892531008119 4775 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2080 5212524 12.4 µM -3.05693537468152 0.0014822761079183 no 3345 0.00111806240408978 4778 260183
SGTC_2123 5259487 200 µM -3.09785483958583 0.00130262029930469 no 3346 0.000974634411567914 4793 2173474
SGTC_433 pimozide 108 µM -3.10372235103524 0.00127855804220197 no 3347 0.000955512884971654 4767 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2442 5158906 48.48 µM -3.18490981126383 0.000984806230374214 yes 3348 0.000723995638696719 4793 1893835
SGTC_3020 9089140 49.47 µM -3.20981644663435 0.000907975857091281 yes 3349 0.000664098790785732 4796 17217859
SGTC_2329 6138490 200 µM -3.29661324263149 0.000681259462103176 yes 3350 0.000489290776811787 4776 720019
SGTC_2065 5221596 34.26 µM -3.34476775680233 0.000579253414715321 yes 3351 0.000411757484158018 4795 788581
SGTC_3209 9113616 49.47 µM -3.42968114294347 0.000433025896505164 yes 3352 0.000302145460896521 4793 16649353
SGTC_535 2293-4129 48.2 µM -3.60883365087943 0.000229590629012135 yes 3353 0.000153788374700632 4795 396118 YIL048W NEO1
SGTC_2313 7726885 200 µM -3.61423718301938 0.000225140298971262 yes 3354 0.000150616603395644 4794 726423
SGTC_526 4469-0568 170 µM -4.70976457914511 2.49786639613304e-06 yes 3355 1.24001541890669e-06 4803 2901964