SGTCid condition conc unit ENB1|YOL158C.score ENB1|YOL158C.strain.pval ENB1|YOL158C.strain.significant ENB1|YOL158C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_114 0364-0001 490.298 µM 4.43671289531124 4.4522632613284e-06 yes 1 4.56714961482076e-06 33 4003655 SGTC_1727 st034309 9.9045 µM 3.89842427400819 4.60637260665618e-05 yes 2 4.84103342764943e-05 43 870305 SGTC_2576 guaiol 23.12 µM 3.86699543100507 5.23584081339658e-05 yes 3 5.50922457350515e-05 22 227829 SGTC_2693 st077581 40.7 µM 3.85043545322515 5.59933595220808e-05 yes 4 5.89540010414789e-05 38 25238761 SGTC_2504 purpurogallin 52.29 µM 3.8147807874042 6.46432891512574e-05 yes 5 6.81519378035416e-05 24 5281571 An antioxidant. SGTC_353 1988-1175 58.3 µM 3.79014210144833 7.13404737489791e-05 yes 6 7.52805632468503e-05 29 2788357 SGTC_2567 aureobasidin a 60 nM 3.51427811021146 0.000207028203653302 yes 7 0.000220475445720139 114 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1737 st035557 69.7 µM 3.39477946255119 0.000321365110953918 yes 8 0.00034341951262401 27 5716916 SGTC_74 000s-0487 160.283 µM 3.38938453900243 0.000327707060752721 yes 9 0.00035024850930968 38 677548 SGTC_539 4859-0462 2.54 µM 3.32530861937441 0.000412477620986213 yes 10 0.000441603559040811 49 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_219 mitoxanthrone 164.414 µM 3.32308266731388 0.000415759290497149 yes 11 0.000445142633354132 69 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_817 1391-0715 46 µM 3.31643606480061 0.000425702911387116 yes 12 0.000455867230380066 35 1353946 SGTC_2341 7987486 176.74 µM 3.31508219215474 0.000427755215478584 yes 13 0.000458080912667533 35 1258686 SGTC_2346 9031566 143.75 µM 3.24471687701344 0.000547959183013958 yes 14 0.000587837260815146 50 4771086 SGTC_1125 tnp00248 1.32998 µM 3.21265321650538 0.000612498240706586 yes 15 0.000657574897470899 77 24207736 SGTC_649 1123-0311 367 µM 3.14215094865422 0.000779827053695467 yes 16 0.000838557742034867 118 693629 YIL048W NEO1 SGTC_756 0508-1999 28.3 µM 3.06006176760713 0.00102719054657052 no 17 0.0011064567394092 65 6753853 SGTC_716 1683-5115 658 µM 3.01989966936556 0.00117279196086739 no 18 0.00126429216311699 62 723597 SGTC_2764 methyldopa 94.69 µM 3.00208004524746 0.00124325584746914 no 19 0.00134070829546109 70 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2506 ethyl hematommate 54.16 µM 2.93325414297289 0.00155330300785806 no 20 0.00167714598873927 64 3940691 An allergen. SGTC_2204 7233102 200 µM 2.88199084511418 0.00182838084786303 no 21 0.00197585607396287 34 2172480 SGTC_2789 5281112 71.43 µM 2.86562650278729 0.00192510109061007 no 22 0.00208092476207371 100 765948 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.8568050959887 0.00197914619855786 no 23 0.0021396425950979 98 23665772 A membrane-active detergent. SGTC_357 1325-0123 420 µM 2.82146201465791 0.0022097720956805 no 24 0.00239026493010085 46 1098503 SGTC_763 3453-1109 128 µM 2.8213399165109 0.00221060938534076 no 25 0.00239117497164446 71 1560353 SGTC_2351 9026858 72.31 µM 2.82082486385235 0.00221414453126669 no 26 0.00239501729706922 74 1409300 SGTC_1725 st036284 20.55 µM 2.81662471628524 0.00224316470875346 no 27 0.00242655982692917 94 707914 SGTC_1851 st056236 18.9 µM 2.77943514349565 0.00251554976685578 no 28 0.00272267630968697 76 5393171 SGTC_1246 0422-0085 105 µM 2.76273231363668 0.00264734560850099 no 29 0.00286598772955802 106 264295 SGTC_1689 st020265 53.493 µM 2.75216234947381 0.00273393956162869 no 30 0.00296015813850682 62 5758320 YPR016C TIF6 SGTC_2032 5185112 25.99 µM 2.72035045491729 0.00301019943031143 no 31 0.00326063806986357 70 5718189 SGTC_1712 st032288 53.4 µM 2.72011807196576 0.0030123068346939 no 32 0.00326293049649572 306 2883011 SGTC_1503 4585-0012 61.3 µM 2.66813213111552 0.0035185461143821 no 33 0.0038137127505206 90 2922052 SGTC_117 lucigenin 22.078 µM 2.66000838466712 0.00360421413857486 no 34 0.0039069353126659 186 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_136 0097-0015 404.482 µM 2.63411657007126 0.00388988446612377 no 35 0.00421782605040577 106 4861337 SGTC_1772 st048439 82.2 µM 2.6286302455979 0.00395296027096523 no 36 0.00428647595251556 115 2927068 YDL195W SEC31 SGTC_2129 girgensonine 121.053 µM 2.5930567356001 0.00438464493979414 no 37 0.00475635381441389 129 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1340 1486-1359 257 µM 2.57703829304458 0.00459242923310631 no 38 0.00498254551887281 96 4309068 SGTC_1848 st056003 16.4 µM 2.57299214213303 0.00464628535075254 no 39 0.00504117484036989 100 146492 SGTC_2119 5528445 120.635 µM 2.55962854558314 0.00482818764060912 no 40 0.00523920478498535 111 791935 SGTC_2309 7664088 163.95 µM 2.53505037499481 0.00517938123987307 no 41 0.00562155783903041 160 704922 SGTC_858 0438-0351 2.77 µM 2.51536720626203 0.00547683648287936 no 42 0.00594542314610526 116 2799119 SGTC_862 0452-0056 10.2 µM 2.50537357139308 0.00563359580895266 no 43 0.00611610604483982 105 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3199 9111318 49.47 µM 2.45660004822881 0.00645722987125413 no 44 0.00701293705250889 124 8548020 SGTC_730 1436-0052 41.2 µM 2.45014697717457 0.00657382327574154 no 45 0.0071398956218715 92 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_828 2074-0507 139 µM 2.44561701754618 0.00665677841405211 no 46 0.00723022573694165 129 X828 SGTC_2555 cholic acid 100 µM 2.43581170592393 0.00683951470474361 no 47 0.00742920836943989 95 6708657 Influences liver metabolism. SGTC_2201 6605497 169.863 µM 2.42786224439085 0.00699090229185558 no 48 0.00759405546357342 86 670741 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.41584640965558 0.00722534420481204 no 49 0.00784934087130618 122 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1968 st069590 43.6 µM 2.40412671116999 0.00746065971848527 no 50 0.00810557656728312 102 6384066 SGTC_2779 methotrexate 400 µM 2.40325018877539 0.0074785274713309 no 51 0.00812503274794747 154 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1421 4029-0249 71.4 µM 2.37188467240834 0.00814322123978664 no 52 0.00884880688202731 134 2894095 SGTC_1520 flindersine 88 µM 2.35662217250003 0.00848504292656125 no 53 0.00922100005549036 156 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2839 9003951 25.97 µM 2.35090132609787 0.00861637595050206 no 54 0.00936399975339534 100 2990634 SGTC_1451 4152-0210 104 µM 2.3427957945153 0.00880550578116547 no 55 0.00956992778425333 154 659563 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.32987009929821 0.00911463783527671 no 56 0.00990650889772234 116 2724278 An inhibitor of dopamine biosynthesis. SGTC_540 1187-0821 17.3 µM 2.31990187401448 0.00935948805157219 no 57 0.0101730930922712 147 847520 SGTC_1251 0490-5699 265 µM 2.31980904206731 0.00936179507239655 no 58 0.0101756048621461 170 3883818 SGTC_2292 7671323 168.05 µM 2.31893332674271 0.00938358247590148 no 59 0.0101993258762758 184 937504 SGTC_2115 tiliquinol 12.7705 µM 2.30428312337565 0.00975470631958127 no 60 0.0106033778480037 111 71208 A bioactive hydroxyquinoline. SGTC_934 2950-0684 338 µM 2.30256435566102 0.00979907618044874 no 61 0.0106516832985944 152 1121253 SGTC_159 3970-0959 50 µM 2.27765185943897 0.0104622639035245 no 62 0.0113736640404566 327 6615653 SGTC_212 3807-4682 38.772 µM 2.27716065900515 0.0104757239711203 no 63 0.0113883167333547 256 3125501 YBL034C STU1 SGTC_196 k015-0023 18.111 µM 2.26792358257948 0.0107316669314729 no 64 0.0116669323564553 150 5211998 SGTC_2084 5306078 60.6385 µM 2.2573322083779 0.0110318203165333 no 65 0.0119936621202555 155 679340 SGTC_98 0074-0023 107.663 µM 2.22762092934723 0.0119131120050745 no 66 0.0129529018998634 196 3563821 SGTC_2692 st077426 47.7 µM 2.22619328190676 0.0119569546277264 no 67 0.0130006188840184 165 25238571 SGTC_3125 9127534 49.47 µM 2.22192241898563 0.0120889480502094 no 68 0.0131442745144468 107 1639235 SGTC_797 k781-0471 270 µM 2.21919864506385 0.0121737859497182 no 69 0.0132366066100685 163 23738129 SGTC_1508 1080-0625 72.9 µM 2.20620934482153 0.0125855011313753 no 70 0.013684672640377 129 767111 SGTC_1649 st011737 51.3 µM 2.20112020872049 0.0127500650264847 no 71 0.013863757500839 140 1761035 SGTC_1248 0469-0687 58.6 µM 2.19201362222024 0.0130491875621169 no 72 0.0141892615164083 185 4017482 SGTC_2130 NSC 7 2.4545 µM 2.19169412796819 0.0130597911681755 no 73 0.0142008000140006 210 21448 SGTC_1058 3448-5425 97.3 µM 2.18364701062096 0.013329331766989 no 74 0.0144940981540902 185 7279705 SGTC_522 1273-0010 11.6 µM 2.18158721785318 0.0133990926259842 no 75 0.0145700055450338 175 5705015 SGTC_176 1486-1328 72.834 µM 2.18060418324207 0.0134324969326233 no 76 0.0146063527285933 252 22310231 SGTC_173 1273-0061 2.693 µM 2.17133770588583 0.0137509286097016 no 77 0.0149528270249629 330 2847414 YPL266W DIM1 SGTC_22 0964-0034 14.468 µM 2.16233381007573 0.0140665533953581 no 78 0.0152962277219559 226 138402 SGTC_2362 9071156 126 µM 2.15367496201514 0.0143759523019221 no 79 0.0156328355037436 170 653133 SGTC_188 3229-0966 278.469 µM 2.15298542667607 0.0144008408486826 no 80 0.0156599119450413 212 5722370 SGTC_2602 kawain 100 µM 2.15195894182551 0.0144379601943113 no 81 0.0157002941352894 208 5369129 SGTC_190 3970-0790 3.722 µM 2.14169446810212 0.0148136924005563 no 82 0.0161090380841185 144 2832352 SGTC_655 k060-0012 42 µM 2.14001363275868 0.0148760140394303 no 83 0.01617683251377 166 5994525 SGTC_108 0509-0257 621.132 µM 2.13900334887186 0.0149135814909016 no 84 0.0162176985772234 244 536624 SGTC_393 acivicin 6.25 µM 2.11160820306315 0.0159638191472487 no 85 0.0173600341934881 167 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_822 1487-0950 154 µM 2.10450267879128 0.0162463584618837 no 86 0.0176673105932783 185 1958375 SGTC_2269 7935389 174.42 µM 2.10349934805546 0.016286597334456 no 87 0.0177110711096652 188 97605 SGTC_2176 5809774 33.9695 µM 2.10266993067602 0.0163199257821782 no 88 0.0177473161504702 166 2870539 SGTC_227 fluconazole 33.516 µM 2.09182034312368 0.0167613018652543 no 89 0.0182272949318951 271 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2141 5621638 7.665 µM 2.08081267068599 0.0172195048765843 no 90 0.0187255279687062 171 2856238 SGTC_1370 2001-0092 44.6 µM 2.06776456054974 0.0177764644710167 no 91 0.0193310838510123 238 790957 SGTC_1169 aniline yellow 25.8 µM 2.05054028989451 0.0185351599762421 no 92 0.0201558681661351 161 6051 A DNA damaging agent. SGTC_1359 1582-0056 520 nM 2.04977633609385 0.0185694396804421 no 93 0.0201931309213285 230 3661189 SGTC_1315 1237-0019 3.69 µM 2.04923994919101 0.0185935403720102 no 94 0.0202193287210232 181 825140 SGTC_1698 5-fluorocytosine 1.055 µM 2.04056528702457 0.018987019297767 no 95 0.0206470277497721 161 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2263 7948595 193.29 µM 2.04022351770665 0.0190026657227691 no 96 0.0206640342021565 147 2971371 SGTC_1363 1636-0063 10.4 µM 2.03771124953225 0.0191180159143218 no 97 0.0207894092440721 225 6072185 SGTC_630 4356-0227 183 µM 2.00787260381441 0.0205341885130555 no 98 0.0223284155510067 182 779312 SGTC_218 alverine citrate 93.75 µM 2.00478388894936 0.0206857330991063 no 99 0.0224930778222617 177 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2973 9094665 17.96 µM 2.00369939234215 0.0207391669901964 no 100 0.0225511357078029 260 25237061 YIL048W NEO1 SGTC_887 0885-0007 9.62 µM 1.99510829793885 0.0211666006090791 no 101 0.023015534769098 246 5719458 SGTC_1417 3966-0327 90.4 µM 1.98238699102915 0.0218131976566819 no 102 0.0237179722290096 237 651118 SGTC_3004 9076122 71.4286 µM 1.97540464131615 0.0221751332780307 no 103 0.0241111232592535 238 44782551 SGTC_1161 k007-0610 110 µM 1.95866390950162 0.0230635908509463 no 104 0.0250760798433245 365 5843850 SGTC_3238 9133470 49.47 µM 1.95637272517261 0.023187488706929 no 105 0.0252106313724654 186 3534688 SGTC_2199 6590217 200 µM 1.95448558501252 0.0232899578989553 no 106 0.0253219089874463 134 703109 SGTC_731 3966-0296 387 µM 1.94549423676475 0.0237834246667627 no 107 0.0258577613438959 231 660956 SGTC_634 1611-4317 11.2 µM 1.94373940195324 0.023880752369051 no 108 0.0259634422826967 252 2843522 SGTC_2384 9036245 200 µM 1.92840833639497 0.0247453761134223 no 109 0.0269021778666501 231 6462766 SGTC_1342 1486-1464 234 µM 1.92778806542778 0.0247809030857119 no 110 0.026940746394399 233 3253938 SGTC_2754 granisetron 64.02 µM 1.92761400099204 0.0247908805779387 no 111 0.0269515780333564 265 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1793 st048256 72.231 µM 1.91510544209096 0.0255167527460805 no 112 0.0277395289705326 185 672022 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.9146384962628 0.025544190640626 no 113 0.0277693110666973 137 77254 SGTC_327 1273-0057 3.96 µM 1.91176940765272 0.0257133220223322 no 114 0.0279528886543679 247 3108138 SGTC_865 0488-0499 301 µM 1.9085532730659 0.0259040248504657 no 115 0.0281598723269617 230 9634651 SGTC_2843 9000894 45.46 µM 1.89692684747877 0.0266033198241796 no 116 0.0289187967598841 139 2242070 SGTC_435 c-PAF 6.7 µM 1.89496825267483 0.0267226617600199 no 117 0.0290483038828894 284 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_26 0302-0163 425.158 µM 1.89067642987176 0.0269857368070476 no 118 0.0293337753427777 204 3100915 SGTC_1832 st054113 55 µM 1.88190097354918 0.0275303761111371 no 119 0.0299247311222084 201 1251267 SGTC_1665 st014639 11.4 µM 1.87967066613758 0.027670248969365 no 120 0.0300764878935019 292 981133 YIL048W NEO1 SGTC_382 3229-0966 23.2 µM 1.86194429650015 0.0288031439191735 no 121 0.0313054711680135 263 5722370 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.8534349412578 0.0293605266315729 no 122 0.0319100215161695 261 3256 An antibiotic and ribosome inhibitor. SGTC_648 0375-0473 33.3 µM 1.84952006596288 0.0296199523498886 no 123 0.03219137653915 298 1713139 SGTC_973 1325-0077 65.9 µM 1.84781046135236 0.0297338374348909 no 124 0.0323148835019622 272 2835149 SGTC_2791 5663188 71.43 µM 1.84156402329555 0.030153036101533 no 125 0.0327694737828065 264 54690634 SGTC_841 0251-0215 91.2 µM 1.83634767521959 0.0305068486764871 no 126 0.0331531264739244 343 3888614 SGTC_2902 5787006 60.46 µM 1.81748807791722 0.0318148594518513 no 127 0.0345712060868762 286 591003 SGTC_1740 st038286 13.222 µM 1.81182519408491 0.0322165357928698 no 128 0.0350066054690321 296 716786 SGTC_3190 9110366 49.47 µM 1.80683167442275 0.0325741975320777 no 129 0.035394264210685 219 17123768 SGTC_398 bronopol 33.3 µM 1.80157653407325 0.0329541283086407 no 130 0.0358060279874828 297 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1132 3456-3614 2.5 µM 1.80126269218284 0.0329769332157006 no 131 0.0358307425955879 373 3125502 SGTC_882 0843-0131 351 µM 1.7907002533478 0.0337520555976343 no 132 0.0366707045243424 292 5425421 SGTC_2605 digitonin 300 nM 1.78943516834685 0.0338458907736014 no 133 0.036772379885352 338 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2946 9065502 71.43 µM 1.78900208730757 0.0338780629694801 no 134 0.036807239699305 162 16489101 SGTC_1338 1486-1223 76 µM 1.78621276055421 0.0340858763363664 no 135 0.0370324078740139 296 3444526 SGTC_938 3126-1755 342 µM 1.78467659961465 0.0342007718775641 no 136 0.0371568943415699 277 1777771 SGTC_2268 7933382 153.85 µM 1.78051157292427 0.0345138932739659 no 137 0.0374961385291589 359 935025 YOR257W CDC31 SGTC_2522 biochanin a 4.94 µM 1.77068337765177 0.0352621067793452 no 138 0.0383066840765535 265 5280373 A possible chelator. SGTC_2863 9028737 58.44 µM 1.76710621365334 0.0355377150678953 no 139 0.0386052210499421 231 6460917 SGTC_1735 st034310 56.75 µM 1.76403121153305 0.0357760427829587 no 140 0.0388633622523269 300 871153 SGTC_1450 4112-4260 37.6 µM 1.75194847351135 0.0367252295945064 no 141 0.039891334185628 314 1633175 SGTC_109 0132-0036 33.701 µM 1.75160171380656 0.0367527712240986 no 142 0.0399211588446245 191 67274 A color developer. SGTC_222 nsc-310342 10.666 µM 1.74501854921892 0.0372788557734984 no 143 0.040490820086452 160 432556 SGTC_1123 mangostin 811.285 nM 1.74453231863771 0.0373179549710218 no 144 0.0405331554937478 347 5281650 An antioxidant. SGTC_2782 7736369 71.43 µM 1.74437547048986 0.0373305747250558 no 145 0.0405468197023015 348 2950836 YOL077C BRX1 SGTC_545 4218-0007 221 µM 1.7402532975736 0.0376634899400676 no 146 0.0409072753473487 286 2840508 SGTC_528 3492-0019 172 µM 1.73664820018397 0.0379566281702289 no 147 0.0412246430742212 569 2869262 SGTC_3149 9097855 49.47 µM 1.72520592592354 0.0388993750361715 no 148 0.0422451840675417 286 25236625 YMR079W SEC14 SGTC_90 0870-0863 4.608 µM 1.71453936365771 0.0397952996391378 no 149 0.0432148570634666 348 1738164 SGTC_326 k292-0812 17.5 µM 1.7135411207408 0.0398799973390998 no 150 0.0433065175348437 257 3579357 SGTC_1271 0832-2808 169 µM 1.70016617622955 0.0410290142169927 no 151 0.0445498362448896 326 3663794 SGTC_718 1130-0073 349 µM 1.68940097260752 0.0419732100617905 no 152 0.0455713073736239 348 6740020 SGTC_2491 paeonol 100 µM 1.68935791793735 0.0419770213258287 no 153 0.045575430166101 271 11092 Increases levels of cortical cytochrome oxidase. SGTC_1718 roemerine 11.9335 µM 1.6842351050377 0.042432504001992 no 154 0.0460681206773066 395 235224 An aporphine alkaloid with mutagenic activity. SGTC_2847 9005661 71.43 µM 1.67859707786874 0.0429384078268198 no 155 0.0466152982287603 201 2991449 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.67101789990403 0.0436261602135353 no 156 0.0473590711310677 216 88881 An O-methylated flavonoid and antioxidant. SGTC_2212 7123476 200 µM 1.67070301117011 0.0436549251872839 no 157 0.0473901769060922 226 1085715 SGTC_1783 st039459 87.517 µM 1.67006960578519 0.0437128328990871 no 158 0.0474527964180795 387 729761 SGTC_75 0159-0059 199.013 µM 1.66981368850984 0.0437362471525025 no 159 0.0474781156223109 318 5377270 SGTC_2840 9008771 71.43 µM 1.66940019395556 0.0437740997679763 no 160 0.0475190476223825 261 2992978 SGTC_699 0375-0592 111 µM 1.66347059962783 0.0443198262996097 no 161 0.0481091356255915 316 762578 SGTC_1507 4075-3230 155 µM 1.6598557328289 0.044655199795887 no 162 0.0484717393152453 274 659771 SGTC_1383 3049-0032 20.7 µM 1.65866805301678 0.0447658332319065 no 163 0.0485913501585351 351 712864 SGTC_1483 3453-0561 55.9 µM 1.6583453554851 0.0447959308962634 no 164 0.048623889656728 376 4546991 SGTC_2518 prenyletin 46.28 µM 1.65518873011997 0.0450912060978283 no 165 0.0489431102847734 233 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3181 9108277 49.47 µM 1.6537751798574 0.0452239383594461 no 166 0.0490866003896398 328 17097298 SGTC_575 k072-0246 11.9 µM 1.6527140686829 0.0453237830286649 no 167 0.0491945348905556 351 6796779 SGTC_580 1123-0028 41 µM 1.65249302506171 0.0453446043056985 no 168 0.049217042924097 412 1677248 YPR107C YTH1 SGTC_1680 diphenhydramine 100 µM 1.64332208288872 0.0462152671550097 no 169 0.0501581558426396 359 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1426 4048-4480 71.7 µM 1.6425472178685 0.0462894415248549 no 170 0.0502383245473651 344 14224343 SGTC_946 3434-1334 87.4 µM 1.64143673789623 0.0463959094409036 no 171 0.0503533945123481 358 4047976 SGTC_318 1488-0629 67.2 µM 1.63718433030427 0.0468054304699018 no 172 0.0507959800796884 315 3662576 SGTC_1145 3546-0597 10.2 µM 1.63641495815235 0.0468798324144926 no 173 0.0508763853532542 386 875334 SGTC_1134 3477-0009 42.5 µM 1.63304808150342 0.0472065419224131 no 174 0.0512294423362832 404 3973534 SGTC_3061 glucosamine 200 µM 1.63039193810891 0.0474655701762143 no 175 0.051509343725101 307 91431 and experimental redox chemotherapeutic SGTC_2752 diclazuril 33.15 µM 1.62876113935879 0.0476251697611205 no 176 0.0516817971168113 526 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2906 7926292 26.41 µM 1.6262293106024 0.0478738007959124 no 177 0.0519504415519273 366 2966319 SGTC_2004 4023728 41.89 µM 1.62381448547436 0.0481119089894033 no 178 0.0522077037867436 391 360084 YDR527W RBA50 SGTC_2192 5915882 198.485 µM 1.62330435405853 0.0481623303486424 no 179 0.052262179624552 300 2876149 SGTC_3131 9127911 49.47 µM 1.61413004361815 0.0490763566360283 no 180 0.0532496109769357 358 45595681 SGTC_1346 1488-2224 62.4 µM 1.61189715357991 0.0493009005704344 no 181 0.0534921608549087 357 3722427 SGTC_1455 4262-0120 131 µM 1.6082166746172 0.0496728066312716 no 182 0.053893866224236 369 1529587 SGTC_1146 3579-1023 7 µM 1.60499109493423 0.0500005834262231 no 183 0.054247882217458 415 X1146 SGTC_2156 5649887 115 µM 1.60044545160363 0.0504654277526479 no 184 0.0547498994410875 411 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1418 3966-3099 2.4 µM 1.59437662942326 0.0510913943749414 no 185 0.0554258518399259 395 740335 SGTC_1281 0884-0031 11.8 µM 1.59246381968241 0.0512899661805949 no 186 0.0556402631551415 401 1548255 SGTC_2331 7980721 200 µM 1.59091138801711 0.0514515775103896 no 187 0.0558147596585364 386 2981221 SGTC_1402 3909-7673 35.9 µM 1.58854872338035 0.0516983126654663 no 188 0.0560811563026671 361 5328014 SGTC_167 3672-0051 66.205 µM 1.58648085638809 0.0519150328731903 no 189 0.0563151356962974 360 3237971 SGTC_848 0368-0089 85.6 µM 1.58072364189254 0.0525222147753554 no 190 0.0569706201259996 388 762535 SGTC_2361 9034121 116 µM 1.57723529734319 0.0528928450823412 no 191 0.0573706969955946 364 6496917 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.57671715262842 0.0529480735503335 no 192 0.0574303109124875 339 279621 SGTC_12 0849-0099 9.267 µM 1.57421087498968 0.0532158608448684 no 193 0.0577193530101663 369 6071388 SGTC_829 1635-0120 117 µM 1.57187704555955 0.0534661869410649 no 194 0.05798953448997 431 285054 SGTC_2808 7946468 45.46 µM 1.56890943342602 0.0537858389370526 no 195 0.0583345217381114 430 2970879 SGTC_13 0199-0087 65 µM 1.56740632931025 0.0539483200057342 no 196 0.0585098727404932 386 4589825 SGTC_55 0767-0285 6.563 µM 1.56409856710284 0.0543072476501503 no 197 0.0588972112194832 440 3116166 SGTC_2148 5546263 113.568 µM 1.55879938116333 0.0548862010783269 no 198 0.059521935368972 389 792097 SGTC_546 peri-Naphthalide 147 µM 1.54963278692073 0.0558991872509255 no 199 0.0606148394197017 387 223824 A penicillin ester. SGTC_751 0833-0568 350 µM 1.54933161550695 0.0559327178215684 no 200 0.0606510117152611 370 6954252 SGTC_2089 5281248 129.67 µM 1.54286378946164 0.0566566417973009 no 201 0.0614319141067864 407 2737878 SGTC_1119 parthenolide 318.541 nM 1.54091677594273 0.0568760045503664 no 202 0.0616685211716913 487 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_72 0744-0168 198.391 µM 1.53175399568146 0.0579173340373944 no 203 0.0627915761949214 400 677577 SGTC_1499 4480-0877 67.3 µM 1.52457872541837 0.0587432029889565 no 204 0.0636821035541703 339 2861909 SGTC_2220 6782180 200 µM 1.51993802501962 0.0592822479612154 no 205 0.0642632762491678 308 833803 SGTC_694 1315-0438 43.2 µM 1.51458759624832 0.0599085373218539 no 206 0.0649384376553073 351 6793154 SGTC_2717 st081029 62.2815 µM 1.51360277839703 0.0600243769303136 no 207 0.0650633080182154 366 5292846 SGTC_734 2023-0417 80 µM 1.51182220291764 0.0602342630306648 no 208 0.0652895497396005 427 3935732 SGTC_1231 0242-0792 125 µM 1.50916434086443 0.060548627923784 no 209 0.0656283952293466 406 3707635 SGTC_20 0481-0013 4.944 µM 1.50296189359537 0.0612872293283706 no 210 0.0664244354054768 434 182045 SGTC_2695 st077686 51.995 µM 1.5020184200332 0.0614001945361801 no 211 0.0665461758800328 387 2876092 SGTC_512 prima-1 270 µM 1.50064659238383 0.0615647381002971 no 212 0.0667234967823368 433 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3111 9122088 49.47 µM 1.49783144940739 0.0619034780169037 no 213 0.0670885238059431 298 16876704 SGTC_3173 9105693 49.47 µM 1.49675195739736 0.0620337560772974 no 214 0.0672289056479704 448 17096658 SGTC_3047 9092122 49.47 µM 1.49448109007856 0.0623085130903009 no 215 0.0675249604134695 420 17173831 SGTC_3202 9113761 49.47 µM 1.48813420204807 0.0630814707479814 no 216 0.0683577526302712 516 4798415 SGTC_2061 5245884 80.95 µM 1.48053790471394 0.0640163827044684 no 217 0.069364876420402 450 573863 SGTC_3117 9124945 49.47 µM 1.47918666027329 0.0641838096663235 no 218 0.0695452169012617 361 17592065 SGTC_2694 st077685 81.9 µM 1.47608519612434 0.064569386019653 no 219 0.0699605112562905 437 2838096 SGTC_2025 5147754 141 µM 1.47402449453065 0.0648265672644213 no 220 0.0702374981139345 395 315777 YLR208W SEC13 SGTC_2335 9018011 154.17 µM 1.47256862464676 0.0650087427770732 no 221 0.0704336950740554 494 6458208 SGTC_3340 9146634 11.102 µM 1.47199543894895 0.0650805754171344 no 222 0.0705110546242248 432 4907387 SGTC_2595 hexamethylquercetagetin 100 µM 1.47197205612053 0.0650835071015297 no 223 0.0705142118550284 414 386331 SGTC_1754 st042065 16.137 µM 1.46720401885117 0.0656834565565423 no 224 0.0711602820059408 600 1126236 YIL048W NEO1 SGTC_1422 4031-0024 15.5 µM 1.46144220129438 0.0664141615663094 no 225 0.0719470632250111 427 782427 SGTC_328 k915-0120 63.5 µM 1.45725008988273 0.0669497426288005 no 226 0.0725236792116576 421 6624543 SGTC_2167 5876490 200 µM 1.4560397270868 0.0671049976027497 no 227 0.0726908188742001 455 686534 SGTC_2380 9035439 200 µM 1.45069382490279 0.0677940567167421 no 228 0.0734325678645312 507 6462575 SGTC_1324 1418-0026 34.4 µM 1.44957860202494 0.0679384897298276 no 229 0.0735880333206062 472 1372513 SGTC_2046 4110841 106 µM 1.43977731273238 0.0692180986627773 no 230 0.0749652059185006 441 44119630 YMR134W ERG29 SGTC_2999 9069765 71.4286 µM 1.43591642947094 0.0697272249423471 no 231 0.075513061424985 478 2097066 SGTC_1216 1165-0504 9.65 µM 1.43396634231465 0.0699854719859813 no 232 0.0757909339846804 467 6304004 SGTC_3076 9116187 49.47 µM 1.43331568908873 0.070071800530604 no 233 0.0758838201788947 425 27241210 SGTC_198 3454-2873 16.191 µM 1.42993972482714 0.0705210386272368 no 234 0.076367159671111 447 710957 SGTC_2920 7982904 15.77 µM 1.427385668841 0.0708623742972331 no 235 0.0767343796831994 400 6456808 SGTC_863 0466-0191 129 µM 1.42565067305181 0.0710949700184085 no 236 0.0769846007554187 528 765160 YPR165W RHO1 SGTC_635 k038-0028 24.7 µM 1.42518359551441 0.0711576870736198 no 237 0.0770520685083707 476 4035102 SGTC_968 1309-0633 340 µM 1.42033098197532 0.0718117897357776 no 238 0.0777556727443115 456 3761976 SGTC_2965 9082772 38.63 µM 1.41861021923023 0.072044842360467 no 239 0.0780063424419813 499 16459634 SGTC_2387 9077560 195.08 µM 1.41730683401615 0.0722217527874351 no 240 0.0781966189874551 471 5303272 SGTC_1487 3970-0795 2.82 µM 1.4159568769702 0.0724053352791134 no 241 0.0783940652954968 478 3765103 SGTC_2398 5228213 48.84 µM 1.41568116783966 0.0724428732673288 no 242 0.078434437282482 569 80771 YMR134W ERG29 SGTC_371 0195-0006 7.36 µM 1.41252433967388 0.0728737409200402 no 243 0.0788978145895489 389 3928593 SGTC_1420 4'-methoxyflavone 42 µM 1.41131576243539 0.0730392149639759 no 244 0.0790757643957276 449 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_884 0851-0618 334 µM 1.41013538962908 0.0732011047822983 no 245 0.0792498546389468 500 9642473 SGTC_1403 3909-7815 62.9 µM 1.40513934544711 0.0738893608767972 no 246 0.0799899231193058 418 6615483 SGTC_890 0929-0006 47.2 µM 1.40377024915937 0.0740788284377905 no 247 0.0801936379365456 437 1378169 SGTC_2288 7946289 167.31 µM 1.40305343170378 0.0741781758449247 no 248 0.0803004531435528 537 1246052 SGTC_3081 9117243 49.47 µM 1.40227532649067 0.0742861325899544 no 249 0.0804165226913474 445 45595589 SGTC_1265 0819-1001 68.8 µM 1.40186252021917 0.0743434553112595 no 250 0.0804781522280395 465 3106768 SGTC_1230 0170-0365 3.77 µM 1.40117182897737 0.0744394409609283 no 251 0.0805813481345274 640 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1567 st069303 68.4 µM 1.39969446167268 0.0746450688985942 no 252 0.0808024164981845 512 5581319 SGTC_2954 9074818 52.69 µM 1.39908705338931 0.074729736898626 no 253 0.0808934397897769 471 16648742 SGTC_859 0439-0102 54.6 µM 1.39880849774482 0.0747685898942768 no 254 0.080935208682556 512 610143 SGTC_380 3970-0968 6 µM 1.39350850973861 0.0755107730059009 no 255 0.0817330367585235 462 2891601 SGTC_11 0438-0307 1.3 µM 1.39031407115396 0.0759608095875293 no 256 0.0822167634110421 458 4011476 SGTC_1849 st056239 19.2 µM 1.38979647620547 0.0760339208909107 no 257 0.0822953442294412 506 5393181 SGTC_2997 9067075 71.4286 µM 1.3895990743511 0.0760618183986477 no 258 0.0823253285031918 530 27209819 SGTC_2476 5806916 10.51 µM 1.38921197885587 0.0761165466846543 no 259 0.0823841500972992 452 2870194 SGTC_2802 7925815 54.55 µM 1.38839092995009 0.0762327273276076 no 260 0.0825090183782392 520 1262923 SGTC_2348 9022543 33.42 µM 1.38712037063233 0.07641278086531 no 261 0.0827025306918741 501 3162678 YDL140C RPO21 SGTC_1658 st012944 20 µM 1.38073055194056 0.0773232036052034 no 262 0.0836809118788937 518 24207260 SGTC_322 k048-0136 19.3 µM 1.38062905492609 0.0773377311140499 no 263 0.0836965225151202 458 6823282 SGTC_864 0469-0573 172 µM 1.37928704550344 0.0775300110984585 no 264 0.0839031345409642 475 689425 SGTC_927 2425-1185 123 µM 1.37205157022947 0.0785729527730998 no 265 0.0850236921651248 467 730375 SGTC_1558 st069300 45.6 µM 1.37051242174423 0.0787961753553153 no 266 0.08526350026227 404 24208000 SGTC_2770 toltrazuril 17.5 µM 1.36305223608592 0.0798849387334618 no 267 0.0864330242449325 513 68591 Kills coccidiodes. SGTC_1913 st060213 96.1 µM 1.36227232053017 0.079999415769068 no 268 0.0865559797937234 544 688959 SGTC_421 streptovitacin 30 mM 1.35993664160065 0.0803429917665559 no 269 0.0869249872484548 544 91467 include heat shock SGTC_2627 acetyl isogambogic acid 100 µM 1.35204582567323 0.081511970972799 no 270 0.0881803280267718 492 6857789 A caspase activator and apoptosis inducer. SGTC_1521 st012942 49.4 µM 1.35011746075997 0.0817995879208975 no 271 0.088489154183499 557 24207259 SGTC_1407 3909-7909 12.3 µM 1.34864392532577 0.0820198818246175 no 272 0.0887256823417479 524 4411780 SGTC_1490 4089-0339 670 nM 1.34632836371475 0.0823669615363463 no 273 0.089098321194658 475 742542 SGTC_1279 0874-0590 65.2 µM 1.34557901551475 0.0824795179258087 no 274 0.0892191614634028 526 3523074 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.34456267045359 0.0826323637545419 no 275 0.0893832525882633 543 688751 SGTC_736 0958-0254 92.6 µM 1.34069982455217 0.0832152335938258 no 276 0.0900089657784114 550 6812352 SGTC_2953 9074162 66.49 µM 1.33775730345943 0.0836613046787603 no 277 0.0904877821601075 488 16451992 SGTC_1612 st002233 45.4 µM 1.3345232120814 0.0841536459912659 no 278 0.0910162223925957 513 1035021 SGTC_451 chloral hydrate 100 µM 1.3333290981147 0.0843359804481306 no 279 0.0912119143463541 606 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2015 5119600 184 µM 1.33108903464738 0.0846788249375463 no 280 0.091579858293335 525 2828786 SGTC_1273 0849-0096 14.1 µM 1.3273674002168 0.085250734975107 no 281 0.0921935890323614 523 5286025 SGTC_3075 9116269 49.47 µM 1.32705034281682 0.0852995911907119 no 282 0.0922460150299584 533 17015205 YNL244C SUI1 SGTC_827 3253-0474 693 µM 1.3254055231193 0.0855533825349169 no 283 0.0925183430615246 553 5402065 SGTC_164 4100-3994 89.624 µM 1.3237006193161 0.0858170410686525 no 284 0.0928012463512022 586 4615967 SGTC_2289 7946404 165.07 µM 1.32322600943024 0.0858905462468649 no 285 0.0928801144700052 625 1246120 YPR165W RHO1 SGTC_386 1509-0011 3.07 µM 1.32198686610443 0.0860826805903207 no 286 0.0930862622259774 631 3107280 SGTC_3226 9131256 49.47 µM 1.32021458453226 0.0863580388253159 no 287 0.0933816919595826 377 17178073 SGTC_2027 5150920 200 µM 1.31724816478431 0.0868204025674486 no 288 0.0938777269904978 523 786715 SGTC_1400 3771-8998 51.5 µM 1.31333868553685 0.0874325790697251 no 289 0.0945344241671311 502 670767 SGTC_2638 epoxomicin 18 µM 1.31256691277001 0.0875538090853884 no 290 0.0946644624800233 579 9915668 A protesome inhibitor. SGTC_603 3794-0023 45.9 µM 1.30915338339179 0.0880915106737838 no 291 0.0952411996751011 513 3802260 SGTC_2523 spermine 47.74 µM 1.3080853108312 0.0882602588795004 no 292 0.0954221875719312 517 1103 A DNA binding polyamine. SGTC_14 0354-0009 295 µM 1.30215926688946 0.089200912459369 no 293 0.0964309732067737 561 1713507 SGTC_1103 duloxetine 36.1 µM 1.30026990603764 0.089502377541046 no 294 0.0967542392822168 610 60835 A selective serotonin reuptake inhibitor. SGTC_957 1187-1561 14.1 µM 1.29809516539754 0.0898503149059146 no 295 0.0971273177109625 563 1538454 SGTC_1030 k029-0042 36.7 µM 1.29725872792616 0.0899844041271734 no 296 0.0972710899717182 603 6080581 SGTC_1157 4092-0394 27.6 µM 1.29627808705371 0.0901417998804812 no 297 0.0974398476200528 612 3659885 SGTC_1525 8-methoxypsoralen 92.5 µM 1.29587614061864 0.0902063725313461 no 298 0.097509080255539 613 4114 Related to psoralen; DNA damaging agent. SGTC_3016 9080866 49.47 µM 1.29288216275761 0.0906884362457625 no 299 0.0980259088058769 581 17066299 SGTC_2682 pyrogallin 40.03 µM 1.29206304285479 0.0908206561616772 no 300 0.0981676565808529 600 822798 An ATP competetive kinase inhibitor. SGTC_2666 tannic acid 100 µM 1.29126253531593 0.0909500098725661 no 301 0.098306328528432 598 16134267 A thiamine antagonist. SGTC_1972 st070201 17.4 µM 1.28919781075645 0.0912842787379127 no 302 0.0986646629706375 567 2829099 SGTC_3073 9114972 49.47 µM 1.28868200214274 0.0913679276651369 no 303 0.0987543309944175 490 41905075 SGTC_151 3013-0144 2.285 µM 1.28804399742966 0.0914714717844129 no 304 0.098865324039115 579 906558 YHR107C CDC12 SGTC_1651 st011928 86.1 µM 1.28405869695944 0.0921202298574851 no 305 0.0995607091819515 560 720198 SGTC_2277 7947813 106.88 µM 1.28249421411366 0.092375837472176 no 306 0.0998346666588308 536 1246798 SGTC_3230 9131665 49.47 µM 1.28231623550797 0.0924049491077674 no 307 0.0998658674432962 412 15943720 SGTC_3052 9092717 49.47 µM 1.28146362450512 0.092544503295858 no 308 0.100015434375435 535 25237534 SGTC_577 r071-0003 38.6 µM 1.28108649056677 0.0926062817694746 no 309 0.100081644208164 700 4568517 YMR134W ERG29 SGTC_1334 1486-0610 236 µM 1.28072053401227 0.0926662584291575 no 310 0.100145922321471 574 3742339 SGTC_3136 9095672 49.47 µM 1.26354565408642 0.0955134612404531 no 311 0.103196575146078 501 17217380 SGTC_2908 7930301 100 µM 1.26245763987539 0.0956959741016005 no 312 0.103392079843125 626 2223178 SGTC_42 0133-0086 60.653 µM 1.26119752861804 0.0959076765349838 no 313 0.103618844420518 527 162923 Model of phenazepam hydroxylation. SGTC_1354 1498-1681 81 µM 1.25831680626878 0.0963929398535175 no 314 0.104138602757352 613 5754243 SGTC_361 000s-0510 1.45 µM 1.25615034829224 0.0967590708828609 no 315 0.104530732315429 592 660 SGTC_1779 st039427 55 µM 1.2548877856662 0.0969729142250881 no 316 0.104759749308421 672 1124498 SGTC_609 0986-0026 86.3 µM 1.25453999932307 0.0970318805567255 no 317 0.104822898265166 602 2848610 SGTC_2257 7960413 200 µM 1.25033956527482 0.0977461335371519 no 318 0.105587765541982 642 2974689 YIL048W NEO1 SGTC_2469 5655019 90.81 µM 1.25014327631861 0.0977796050531374 no 319 0.105623606721652 612 2788239 SGTC_2311 7694451 200 µM 1.24969645940267 0.0978558283398559 no 320 0.105705225597765 587 2163142 SGTC_2461 5755302 26.15 µM 1.2465337082575 0.0983966131881569 no 321 0.106284260995338 619 2788904 SGTC_1509 1326-1131 80 µM 1.24510396581285 0.0986417955333786 no 322 0.106546768277932 548 768313 SGTC_810 3825-7150 143 µM 1.24367148034921 0.0988878964496814 no 323 0.106810248264291 622 22330411 YGL099W LSG1 SGTC_1700 st030840 7.9285 µM 1.24320346851852 0.0989683981343612 no 324 0.106896432447401 638 5499307 SGTC_1444 4112-3581 28 µM 1.23986087139353 0.0995447452265463 no 325 0.107513429360286 587 2877249 SGTC_2436 5633522 8.09 µM 1.23715044565575 0.100013888113154 no 326 0.108015617333113 616 5724242 SGTC_139 0099-0334 718.624 µM 1.23388439963628 0.100581344721467 no 327 0.108622991738583 680 97690 SGTC_492 tmb-8 126 µM 1.23370545824925 0.100612502480251 no 328 0.108656339638842 415 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3090 9117696 49.47 µM 1.23329715395679 0.10068362388908 no 329 0.108732459669531 565 7923821 SGTC_2052 5265182 7.135 µM 1.23307994867843 0.10072147322125 no 330 0.108772968798522 637 1239884 SGTC_2738 aclarubicin 5.55 µM 1.23256463624346 0.100811311038121 no 331 0.10886911879705 487 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3249 9135183 49.47 µM 1.22708521134413 0.101770191274505 no 332 0.109895282805615 638 4902779 SGTC_96 0929-0093 37.281 µM 1.22463565070947 0.10220099681486 no 333 0.110356264645328 560 6991579 SGTC_3253 9135987 49.47 µM 1.22362412333766 0.10237928114586 no 334 0.110547027529893 545 4182430 SGTC_576 1073-0113 22.7 µM 1.22168662444243 0.102721401639969 no 335 0.110913078158577 777 5439563 SGTC_1903 st060211 78.3 µM 1.22117102511013 0.102812585172962 no 336 0.111010636176956 643 688960 SGTC_199 4063-0024 41.6 µM 1.21920514852542 0.10316078928666 no 337 0.11138316916255 610 306215 SGTC_2716 st080858 38.6235 µM 1.21680855504 0.103586441164478 no 338 0.11183853214476 608 5296050 SGTC_3127 9126946 49.47 µM 1.21496841885695 0.103914126206592 no 339 0.112189068346921 529 27243249 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.21427697048346 0.104037451041876 no 340 0.112320988365706 574 6708514 SGTC_3058 9093861 49.47 µM 1.21413415342638 0.104062936718703 no 341 0.112348249945678 597 17217477 SGTC_824 1304-0008 100 µM 1.2131109972373 0.104245651133755 no 342 0.112543692997418 646 768245 SGTC_501 nsc-95397 161 µM 1.2122031605247 0.104407966487217 no 343 0.112717310986043 594 262093 SGTC_1495 4469-0029 237 µM 1.20887463457511 0.105004652020008 no 344 0.113355506253007 742 793680 SGTC_3303 9125618 40.5795 µM 1.20712465408513 0.105319349100334 no 345 0.113692070774397 696 22695467 SGTC_3086 9117350 49.47 µM 1.20514786712304 0.105675652592109 no 346 0.114073111880925 529 2679265 SGTC_3323 9138564 53.9225 µM 1.20514697842424 0.105675812970262 no 347 0.114073283388886 677 43912313 YNL103W MET4 SGTC_1862 st057513 3.81 µM 1.20380771138991 0.105917702471879 no 348 0.114331954242302 594 5393163 SGTC_2121 5257820 149.641 µM 1.20124067816081 0.10638246095779 no 349 0.11482892714122 666 791256 SGTC_2685 mycophenolic acid 18.85 µM 1.20001612217696 0.106604683504976 no 350 0.115066539550052 571 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3251 9135047 49.47 µM 1.1978720763362 0.106994574223969 no 351 0.115483411031749 555 17682963 SGTC_2608 thymoquinone 42.66 µM 1.19779329117865 0.10700892072424 no 352 0.115498749815718 565 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_324 1315-0088 19.6 µM 1.19740526996696 0.107079598268572 no 353 0.115574315287663 536 6787421 SGTC_425 3825-7017 13.1 µM 1.19608575920941 0.107320197288045 no 354 0.115831547157 668 3397440 SGTC_790 1575-0012 79.1 µM 1.19502772015922 0.107513401023138 no 355 0.116038099952726 635 378741 YLR208W SEC13 SGTC_695 3505-6186 243 µM 1.19470826097985 0.107571785259253 no 356 0.116100516861507 638 1819379 SGTC_1398 3558-0053 112 µM 1.19264383471721 0.107949629921856 no 357 0.116504445375407 548 4532369 SGTC_1156 4092-0367 4.88 µM 1.1907442340814 0.108298150589975 no 358 0.116877003530071 641 1357585 SGTC_1882 5615643 20 µM 1.18794479104266 0.108813240679345 no 359 0.117427580728165 580 2253075 SGTC_449 xestospongin c 11.1929 µM 1.18694080965049 0.108998399065695 no 360 0.117625484329135 656 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1081 sertraline 6 µM 1.18557767543588 0.109250156217512 no 361 0.117894561414142 662 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_784 4579-0127 173 µM 1.18518337055113 0.109323058197974 no 362 0.117972476719381 660 1948547 SGTC_2021 4019055 173 µM 1.18334699037129 0.109663042021515 no 363 0.118335828382378 771 44827708 YER133W GLC7 SGTC_282 k297-0036 65.7 µM 1.18322418952241 0.109685804177557 no 364 0.118360154315836 589 5061378 SGTC_939 1165-0479 45.3 µM 1.1806083912438 0.110171469948106 no 365 0.118879164299954 642 1377347 SGTC_1284 0929-0043 16 µM 1.17916360715822 0.110440378099408 no 366 0.119166517230372 651 1239883 SGTC_1037 k284-1091 78.7 µM 1.1738984627562 0.111424326248829 no 367 0.120217849138745 587 3334711 SGTC_996 3970-0799 1.8 µM 1.17355936222594 0.111487911597075 no 368 0.120285783251234 826 6615648 YGL040C HEM2 SGTC_941 3237-0776 460 µM 1.17261995673273 0.111664196802958 no 369 0.120474121403081 606 760008 SGTC_764 1951-2361 146 µM 1.17088925210571 0.111989496087196 no 370 0.120821647927128 641 5438930 SGTC_1694 st024011 44.9 µM 1.17025290339383 0.112109272935512 no 371 0.120949604361717 688 2787533 SGTC_2708 st078559 56 µM 1.16939685392871 0.112270547414355 no 372 0.121121888402646 530 17250902 SGTC_1886 st057356 49.9 µM 1.16913976754116 0.112319013272512 no 373 0.121173661954832 614 24207747 SGTC_2265 7929201 200 µM 1.16901679705097 0.112342200922078 no 374 0.121198431970138 631 1265108 SGTC_3352 9151559 45.5865 µM 1.16860598460571 0.112419689632602 no 375 0.121281207973795 616 17159339 SGTC_1616 st002734 56.1 µM 1.16640308321937 0.112835859095104 no 376 0.121725756271055 680 4026101 SGTC_1188 1403-0014 4.57 µM 1.16340128780814 0.11340472348557 no 377 0.122333363646299 714 9614867 SGTC_1924 st058459 75.1 µM 1.15591367014413 0.114832593622234 no 378 0.123858235255813 630 688683 SGTC_97 0535-0701 19.132 µM 1.15527384965269 0.114955196296454 no 379 0.123989150570115 623 2832013 YGL099W LSG1 SGTC_2477 5967686 25.23 µM 1.15224976931531 0.115535931734526 no 380 0.124609225757097 650 776118 SGTC_2045 5106652 78.05 µM 1.14938620477524 0.116087760777359 no 381 0.125198382949643 651 673349 SGTC_616 4092-0450 108 µM 1.14927226809782 0.116109755810011 no 382 0.125221864744944 691 787165 SGTC_1619 st003326 88.7 µM 1.14602736134128 0.116737414533106 no 383 0.12589191549209 629 2849032 SGTC_1039 k821-0043 94 µM 1.13957553289609 0.117992522347315 no 384 0.127231591760797 679 15992768 SGTC_3026 9090633 49.47 µM 1.1385899752343 0.118185085329477 no 385 0.127437105800968 675 25236842 SGTC_2767 sibutramine 71.45 µM 1.13781889120767 0.118335898296331 no 386 0.127598057475186 683 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_936 3005-4620 401 µM 1.13753637092106 0.118391189250804 no 387 0.127657064507625 738 777207 SGTC_1176 0848-0131 83.3 µM 1.13637720903957 0.118618235511708 no 388 0.127899364990097 734 6769040 SGTC_2932 9016711 44.54 µM 1.13550234320831 0.118789800017445 no 389 0.128082450338249 721 7117328 SGTC_1935 st074532 41.6 µM 1.13523791468292 0.118841689933027 no 390 0.128137823763619 764 2829742 SGTC_584 0986-0246 15.4 µM 1.13211005245104 0.119456698375642 no 391 0.128794084575971 734 53315 YDR232W HEM1 SGTC_46 0329-0187a 2.197 µM 1.13103460493097 0.119668673534801 no 392 0.129020263336961 771 46494817 SGTC_1602 st001878 87.6 µM 1.13010270093594 0.119852570091372 no 393 0.129216475892199 674 595405 YLR310C CDC25 SGTC_1705 st027868 56.3335 µM 1.1298742113579 0.119897689304339 no 394 0.129264615973001 660 292948 SGTC_2827 7993847 71.43 µM 1.12545102771455 0.120773483660772 no 395 0.130198979141071 623 2985692 SGTC_1803 st050068 52.4 µM 1.12485715051958 0.120891413877903 no 396 0.130324786037594 844 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_565 1418-0001 44.5 µM 1.12328260858576 0.121204473502762 no 397 0.13065874383177 731 2862145 SGTC_312 4092-0653 6.84 µM 1.1224613665964 0.121367983694678 no 398 0.130833162498441 785 1148278 SGTC_1059 3448-6867 171 µM 1.12084123317921 0.121691008704043 no 399 0.13117772464028 694 3934407 SGTC_1800 st050079 29.0735 µM 1.1172069157499 0.122417821597616 no 400 0.131952932160055 822 3645560 SGTC_803 4488-1585 147 µM 1.11623089422493 0.122613530188929 no 401 0.132161656735216 695 747204 SGTC_762 1165-0429 115 µM 1.11420892760762 0.123019666320563 no 402 0.132594783165924 684 5967793 SGTC_2432 5630864 12.22 µM 1.11335283658492 0.123191906281132 no 403 0.132778461171128 673 5714970 SGTC_2163 5671233 125 µM 1.11261993538018 0.123339495465568 no 404 0.132935847430581 743 701023 SGTC_1351 1496-0003 46.5 µM 1.11205766313871 0.123452807908758 no 405 0.133056679148403 727 3891978 SGTC_310 1273-0058 1.06 µM 1.11064429981244 0.123737959245684 no 406 0.133360743227317 877 2734232 SGTC_2474 5321570 43.32 µM 1.10868373682646 0.124134273158949 no 407 0.133783320082409 678 2841384 SGTC_1489 4065-0444 182 µM 1.10681659402621 0.124512527628614 no 408 0.134186616134322 682 2877968 SGTC_2711 st079103 59.1 µM 1.10680411851188 0.124515057683452 no 409 0.134189313605556 668 54693780 SGTC_143 4032-1194 15.74 µM 1.10554763333889 0.124770059070782 no 410 0.134461183195866 779 1806963 SGTC_1004 4084-0029 199 µM 1.10284266416573 0.125320265567279 no 411 0.135047748416679 737 716894 YLR208W SEC13 SGTC_234 nsc-17383 10.7 µM 1.09899929318495 0.126104939184629 no 412 0.135884187100372 763 408974 SGTC_2407 paclitaxel 400 µM 1.09798854067034 0.126311864903428 no 413 0.136104746584813 734 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_323 4013-0906 34.3 µM 1.09641027811556 0.126635446766772 no 414 0.136449634019685 698 2910086 SGTC_491 tetrandrine 80.3 µM 1.09508005013181 0.126908623562354 no 415 0.136740783953837 668 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.09501022154302 0.126922974946458 no 416 0.136756079214954 689 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2435 5706476 10.6 µM 1.09495638803592 0.12693403974384 no 417 0.136767871710162 754 5725375 SGTC_2137 5261020 140 µM 1.09494440564321 0.126936502664659 no 418 0.136770496606957 697 763655 SGTC_1167 k781-0610 148 µM 1.09383015657657 0.127165676362527 no 419 0.137014737667506 762 4525169 SGTC_2746 daunorubicin 9.88 µM 1.09102680661671 0.127743529432102 no 420 0.137630543638455 576 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2670 beta-carotene 100 µM 1.08867453504468 0.128229808154269 no 421 0.138148717607982 640 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_875 0709-0210 25.7 µM 1.08754321028741 0.128464141073858 no 422 0.138398406470745 766 6251364 SGTC_2196 6573537 42.6665 µM 1.08288592823947 0.129431940340286 no 423 0.139429529288867 715 2903087 SGTC_149 3970-0822 46.1 µM 1.08196321164711 0.129624282088319 no 424 0.139634437501353 854 3114250 YBL034C STU1 SGTC_1086 cerivastatin 2.18 µM 1.08159833852325 0.129700395070992 no 425 0.139715521556328 695 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1642 st009582 77.7 µM 1.07622644138671 0.130824562637558 no 426 0.140912998530478 685 6739311 SGTC_1448 4255-0083 152 µM 1.0740572526644 0.131280408145981 no 427 0.141398511022538 752 5399660 SGTC_911 3456-4043 236 µM 1.0722824327425 0.131654193753113 no 428 0.141796597386001 757 914281 SGTC_669 0108-0021 26.2 µM 1.07124235415265 0.131873580294444 no 429 0.14203023604182 851 17201 SGTC_702 1488-0190 94 µM 1.07030366800106 0.132071796254877 no 430 0.142241321958367 728 949357 SGTC_262 fenpropimorph 62.5 µM 1.06981013786006 0.132176094016376 no 431 0.142352389057294 678 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2774 tamoxifen 10.92 µM 1.06529528669561 0.133132853814115 no 432 0.143371162514019 732 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1761 st044296 37 µM 1.06379292854423 0.133452278725409 no 433 0.143711257739844 725 1826700 SGTC_1530 rhein 70.4 µM 1.06326267947915 0.13356514375192 no 434 0.143831422355953 788 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_473 2-arachidonoylglycerol 10 µM 1.06213789524764 0.13380477453972 no 435 0.144086544397576 731 5282280 An endocannabinoid. SGTC_1977 st070720 65.3 µM 1.06170330427728 0.133897441511894 no 436 0.144185199413655 690 682188 SGTC_2966 9084041 48.03 µM 1.05846241295682 0.134589881184183 no 437 0.144922339062641 679 17741380 SGTC_2662 daunorubicin 22.37 µM 1.05510964986659 0.135308805487097 no 438 0.145687589578029 710 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_579 4491-1009 110 µM 1.05442162132861 0.135456662584916 no 439 0.145844963794355 952 1271041 SGTC_120 rhodamine 6G 52.259 µM 1.05258675720984 0.135851515473235 no 440 0.146265214584235 900 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_258 haloperidol 50.781 µM 1.0509562721423 0.136203047850854 no 441 0.146639336849325 728 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3068 9116768 49.47 µM 1.04874134549994 0.136681582163877 no 442 0.147148589770006 691 41904888 SGTC_1494 4358-1428 177 µM 1.04841303577992 0.136752611096188 no 443 0.147224175071232 792 1564571 SGTC_2858 9025781 8.96 µM 1.0482175994346 0.136794905207846 no 444 0.147269181875822 852 4894980 YPL153C RAD53 SGTC_2439 5492030 7.2 µM 1.04768870311938 0.136909407773156 no 445 0.147391027025729 738 5722370 SGTC_692 k241-0027 77.8 µM 1.0452804161756 0.137431614081013 no 446 0.147946693076128 731 3600480 SGTC_2377 9073351 62.6 µM 1.04441461360887 0.137619684242246 no 447 0.148146802673746 719 7337946 YHR072W ERG7 SGTC_2190 6049624 200 µM 1.04418587399106 0.137669400522704 no 448 0.148199700607778 687 2265554 SGTC_1257 0669-0121 16 µM 1.04198450255058 0.138148492582657 no 449 0.148709432026344 832 4307855 SGTC_2208 7283366 200 µM 1.03906222957255 0.138786231301232 no 450 0.149387897823253 783 898663 SGTC_3244 9134489 49.47 µM 1.03837148015075 0.138937268686077 no 451 0.149548570983787 743 16584271 SGTC_370 0180-0345 38.7 µM 1.03730148371836 0.139171452065196 no 452 0.14979768726545 681 3989527 SGTC_739 1486-1183 203 µM 1.03596957899991 0.13946333278254 no 453 0.150108167479265 805 4346692 SGTC_88 0180-0332 8.668 µM 1.03483800056296 0.139711639861159 no 454 0.150372286476997 770 3101745 SGTC_2914 7968218 45.32 µM 1.03377060771142 0.139946137749974 no 455 0.150621707703559 735 2977111 SGTC_851 0394-0702 453 µM 1.02852444800168 0.141102564869585 no 456 0.151851598340432 827 762646 SGTC_1350 1495-0454 146 µM 1.0272495026771 0.141384580976626 no 457 0.15215149688347 817 1069057 SGTC_3091 9116372 49.47 µM 1.02646303235008 0.141558737488299 no 458 0.152336690076167 728 17169793 SGTC_2583 asiatic acid 100 µM 1.02637859650432 0.141577443654356 no 459 0.15235658139997 749 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1320 1313-0481 95.3 µM 1.02324707232859 0.142272393721611 no 460 0.15309552081605 821 6813365 YLR208W SEC13 SGTC_2068 5226020 147 µM 1.02113088738319 0.14274332376645 no 461 0.153596215505169 806 1810509 SGTC_1377 2944-0135 198 µM 1.02066639192619 0.142846832199649 no 462 0.153706261259608 800 1894137 SGTC_465 cgp-37157 41 µM 1.02009044503939 0.142975246967501 no 463 0.153842783953298 667 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_710 3448-4187 58 µM 1.01847783167416 0.143335214742641 no 464 0.154225465335948 869 3946412 SGTC_846 0335-0850 148 µM 1.01747457979514 0.143559469307711 no 465 0.154463859527994 772 6819598 SGTC_2815 7968870 71.43 µM 1.01671064548723 0.143730388513008 no 466 0.154645550007519 793 2977326 YHR190W ERG9 SGTC_1637 st007924 17.4 µM 1.01670163841933 0.143732404532303 no 467 0.15464769304749 767 683336 SGTC_1804 st050076 49.1 µM 1.01517387232405 0.144074634984834 no 468 0.15501147643001 790 3895976 SGTC_417 st075190 100 µM 1.01400705900651 0.14433637925019 no 469 0.155289691991318 824 222757 SGTC_670 4204-0025 119 µM 1.01217163784282 0.144748756552837 no 470 0.155727997294902 834 719039 SGTC_2921 7974240 10.71 µM 1.01018560486616 0.145195865889164 no 471 0.156203187339247 765 2979074 YDR527W RBA50 SGTC_2644 guaiazulene 100 µM 1.00869704362678 0.145531589663796 no 472 0.15655997502828 801 3515 A coloring agent. SGTC_394 menadione 8.33 µM 1.00832630664339 0.145615285239607 no 473 0.156648918982099 805 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_140 0062-0056 502.533 µM 1.00780549557935 0.145732915384478 no 474 0.156773923561455 850 3758964 SGTC_3040 9091894 49.47 µM 1.00632853038603 0.146066849408672 no 475 0.157128780316177 727 25236966 SGTC_615 k087-0205 167 µM 1.00461450745993 0.146455024880681 no 476 0.157541254432423 750 9642773 SGTC_886 0866-0150 153 µM 1.00367918366924 0.146667139831227 no 477 0.157766636895027 847 271463 SGTC_2861 9024595 19.48 µM 1.00285065349026 0.146855207976568 no 478 0.15796646239405 725 16482810 SGTC_1297 1068-0111 14.1 µM 1.00226346402283 0.14698859207616 no 479 0.158108181742003 766 767057 SGTC_2452 5863136 48.41 µM 1.00102673999736 0.147269788073115 no 480 0.158406940452548 784 2184096 SGTC_3200 9114385 49.47 µM 1.0000893920915 0.147483154474071 no 481 0.158633624629099 732 17018030 YLR208W SEC13 SGTC_2886 9058944 51.95 µM 0.998880023642544 0.147758746148661 no 482 0.158926407179714 649 4949929 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.998682926647935 0.147803693400601 no 483 0.158974156995797 832 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2730 imipramine 71.33 µM 0.994833672538008 0.148683337094198 no 484 0.159908583129136 921 3696 A tricyclic antidepressant. SGTC_1994 st072947 40.9 µM 0.994696675445503 0.148714708459158 no 485 0.159941905944022 807 5286565 YDL195W SEC31 SGTC_1031 k035-0009 16 µM 0.99363500772257 0.148957972848481 no 486 0.160200297186557 874 5180959 SGTC_3008 9078912 71.4286 µM 0.992940947357293 0.149117149452406 no 487 0.16036936669142 782 16648731 SGTC_2793 7325131 81.82 µM 0.989746955341912 0.149851127206321 no 488 0.161148908929712 781 4176441 SGTC_249 wiskostatin 11.211 µM 0.988238049346406 0.150198709694701 no 489 0.16151803880247 828 2775510 A n-wasp and actin depolymerizer. SGTC_1397 3532-0190 20.1 µM 0.987391949563603 0.150393847096623 no 490 0.161725264707889 746 5322280 SGTC_3176 9106582 49.47 µM 0.98550754716087 0.150829056742619 no 491 0.162187413052457 693 17018027 SGTC_2318 6029776 164 µM 0.982119022302892 0.151613756332492 no 492 0.163020607564162 812 818325 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.981978819562111 0.151646282220157 no 493 0.163055141446841 770 17037758 SGTC_1641 st009299 47.1 µM 0.979377061958649 0.152250710267762 no 494 0.163696853277621 775 4046054 SGTC_3071 9117417 49.47 µM 0.978185236946362 0.152528122845742 no 495 0.163991358351026 721 45595590 YGL055W OLE1 SGTC_1158 4092-0494 91.8 µM 0.977692534957494 0.152642903487448 no 496 0.164113207493226 853 1148199 SGTC_1366 1683-0113 21.9 µM 0.975475071552865 0.153160196415695 no 497 0.164662330628229 803 708623 SGTC_766 1391-0721 126 µM 0.975342107340263 0.153191251368813 no 498 0.164695295105074 841 1020919 YIL115C NUP159 SGTC_1756 st041558 35.5 µM 0.972490390199154 0.153858299246812 no 499 0.165403321672088 916 3955792 SGTC_1770 st043884 66.3 µM 0.971356101668663 0.154124155343774 no 500 0.165685490325473 833 670149 SGTC_606 k015-0008 38.6 µM 0.970256594891364 0.154382149121369 no 501 0.165959303479708 910 1970475 SGTC_411 enrofloxacin 100 µM 0.969337494574369 0.154598030401937 no 502 0.166188413788642 872 71188 A bacterial gyrase inhibitor. SGTC_1561 5-methoxyflavone 52.9 µM 0.967704842898954 0.154982004694321 no 503 0.166595899390627 802 94525 SGTC_65 0798-0905 34.986 µM 0.965241320256948 0.155562578058615 no 504 0.167211977597293 915 3602145 SGTC_503 tyrphostin 8 294 µM 0.965176114700738 0.155577964383202 no 505 0.167228304140743 836 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_600 1495-0418 41.6 µM 0.965116263073186 0.155592088243736 no 506 0.167243291041089 809 5377768 SGTC_1550 gossypolone 36.6 µM 0.963799173111494 0.155903110836372 no 507 0.16757331066669 876 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_293 4049-0273 38.5 µM 0.963758585700572 0.155912701805781 no 508 0.167583487201337 783 1380311 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.963315490124345 0.156017432383561 no 509 0.167694611029544 862 165521 SGTC_1381 2324-0066 62.1 µM 0.961155175131124 0.156528710862494 no 510 0.168237075371938 792 10885928 SGTC_3132 9126706 49.47 µM 0.959981875684297 0.156806855622285 no 511 0.168532168387999 803 850858 SGTC_2619 obliquin 87.91 µM 0.959754095769487 0.156860891270355 no 512 0.168589495178844 899 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2994 9053520 71.4286 µM 0.958395313482511 0.157183486238754 no 513 0.168931728769154 834 4647384 SGTC_2740 felodipine 17.08 µM 0.958159269781967 0.157239570940806 no 514 0.168991226057794 780 3333 L-type calcium channel blocker SGTC_406 estrone 100 µM 0.954406972127706 0.158132895159153 no 515 0.169938839210351 872 5870 A steroid. SGTC_273 hydroxyurea 18.1 mM 0.954378950287173 0.158139578935379 no 516 0.16994592869556 918 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1191 1487-1166 10.6 µM 0.954080335404966 0.158210816145724 no 517 0.170021489605458 931 3955771 SGTC_279 1273-0055 2.93 µM 0.951891253094631 0.158733683971716 no 518 0.170576068005247 915 2847562 SGTC_2172 5754775 163.918 µM 0.950045828392722 0.159175347357267 no 519 0.171044483443721 767 2263357 SGTC_2593 nobiletin 86.24 µM 0.949715836073386 0.159254408797924 no 520 0.171128330472114 786 72344 An anti-infammatory. SGTC_27 0485-0001 32.618 µM 0.947482144731932 0.15979024539592 no 521 0.171696575225458 783 2054479 SGTC_1375 2910-0797 186 µM 0.946476442393055 0.160031886336949 no 522 0.171952816118967 840 742508 SGTC_223 busulfan 5 mM 0.945673145644416 0.160225066681432 no 523 0.172157661796208 774 2478 A DNA alkylator. SGTC_2181 6316240 54.2555 µM 0.945417801351602 0.160286504917069 no 524 0.172222808789221 801 12779990 SGTC_2539 epi(13)torulosol 80 µM 0.945378626672331 0.160295932075069 no 525 0.172232804970785 820 6708597 SGTC_2175 5807670 165.306 µM 0.945235308416025 0.160330423865074 no 526 0.172269378566854 846 241186 SGTC_182 3448-4371 550.524 µM 0.945123625979509 0.160357305360279 no 527 0.172297882406706 910 3491403 SGTC_988 1497-1057 103 µM 0.941888648763233 0.161137228983627 no 528 0.173124826149707 896 3533044 SGTC_2775 cyproheptadine 69.59 µM 0.936855470968584 0.162355595171055 no 529 0.174416453534893 872 2913 A selective serotonin reuptake inhibitor. SGTC_2467 5474540 200 µM 0.936041650689221 0.162553155892209 no 530 0.174625871704488 892 5413519 SGTC_1270 0831-1170 17.3 µM 0.934571296650459 0.162910491326698 no 531 0.175004638556328 928 6764716 SGTC_945 3381-0768 11.3 µM 0.932602429504676 0.163389778024467 no 532 0.175512639260642 912 1126236 YIL048W NEO1 SGTC_1615 st002656 86.5 µM 0.929820052342524 0.164068659878993 no 533 0.176232131091201 864 1584458 SGTC_3354 9151612 71.43 µM 0.9296603252008 0.164107687716238 no 534 0.176273491332014 901 27261949 SGTC_2856 9022925 19.48 µM 0.928359364206953 0.164425789645008 no 535 0.17661059493412 864 4944862 SGTC_352 k048-0007 5.11 µM 0.927288041690471 0.16468804186678 no 536 0.176888500734639 926 6811911 SGTC_3084 9116877 49.47 µM 0.926238926098486 0.164945120476735 no 537 0.177160913647627 828 27241325 SGTC_2400 5203494 178.7 µM 0.925740487480359 0.165067350467398 no 538 0.177290430815844 808 6777674 SGTC_1275 0867-0008 21.1 µM 0.925274270274305 0.165181731999963 no 539 0.177411629491211 887 3422836 SGTC_2420 aureobasidin a 50 nM 0.924798417449149 0.165298530420819 no 540 0.17753538698584 918 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1597 7-benzyloxygramine 47.5 µM 0.922938765030552 0.165755495849722 no 541 0.178019558753818 967 260807 SGTC_3322 9139058 2.11 µM 0.920266170846171 0.166413651300758 no 542 0.178716841333813 890 4908926 YPR165W RHO1 SGTC_2667 digitoxin 100 µM 0.918579760347543 0.166829815324118 no 543 0.179157711197152 856 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2641 levomentholum 100 µM 0.916777710064134 0.167275257737366 no 544 0.179629567575874 864 16666 SGTC_1938 st074717 56.4 µM 0.916504606369168 0.16734283210156 no 545 0.179701146274031 830 17250979 SGTC_1970 st070122 35.8 µM 0.915986778896218 0.167471007048789 no 546 0.179836914675448 873 102928 SGTC_431 k089-0097 107 µM 0.9142644035369 0.167897791968679 no 547 0.180288965068552 919 5499420 SGTC_3299 9121982 43.1275 µM 0.913081328240773 0.168191349763388 no 548 0.180599884841668 895 17594604 YPL160W CDC60 SGTC_2246 7293507 91.5585 µM 0.912650082742923 0.168298437261474 no 549 0.180713302499944 939 887656 SGTC_1201 1889-3372 45.9 µM 0.912128604019601 0.168427990170288 no 550 0.180850511153045 871 5392199 SGTC_1755 st041960 45.185 µM 0.909693583765866 0.169033779934106 no 551 0.181492064453279 901 2257073 SGTC_2010 4012422 159 µM 0.908732563151211 0.16927324943804 no 552 0.181745655549814 895 952393 SGTC_2933 9026794 32.47 µM 0.908528457270319 0.169324137073688 no 553 0.181799542893948 905 17586027 SGTC_935 2996-0153 430 µM 0.903902221374198 0.170480182249283 no 554 0.183023625588616 908 23738523 SGTC_2116 5511452 16.8835 µM 0.903585353286138 0.170559548604705 no 555 0.183107655314074 914 870744 SGTC_2191 5911152 200 µM 0.902374514557824 0.170863046811124 no 556 0.183428977282498 921 2875902 SGTC_683 panaxydol 45 µM 0.902322852649282 0.170876003613579 no 557 0.183442694689696 931 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2507 purpurin 79.67 µM 0.902186791694268 0.170910130698178 no 558 0.183478825015712 921 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2617 dihydrotanshinone i 20.83 µM 0.899363079633923 0.171619364085813 no 559 0.18422964903332 933 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2739 tacrine 100.86 µM 0.896620581574794 0.172309996227764 no 560 0.184960705883136 876 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_644 1498-1197 63.3 µM 0.896061509703091 0.172451002301823 no 561 0.18510995634786 962 6741615 SGTC_2252 omeprazole 400 µM 0.895952553633363 0.172478491177297 no 562 0.185139052092677 840 4594 A proton pump inhibitor. SGTC_191 3914-0123 66.505 µM 0.894719887655819 0.172789679053067 no 563 0.185468422358002 778 3144412 SGTC_2255 7941087 197.44 µM 0.892923796795048 0.173243744303383 no 564 0.185948991221829 987 935561 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.891420426793583 0.173624391126964 no 565 0.186351831617829 948 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2737 bleomycin 30.5 nM 0.891082741916802 0.173709964621363 no 566 0.186442391373448 955 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2859 9028643 45.46 µM 0.889972116981618 0.173991599818437 no 567 0.186740429090387 897 17151580 SGTC_2896 9052656 71.43 µM 0.887481131569299 0.17462432555264 no 568 0.187409960155955 948 6469436 SGTC_969 1313-0238 134 µM 0.886296182266432 0.174925822174171 no 569 0.18772897287694 953 5212874 SGTC_1687 st020778 55.3625 µM 0.886189541272942 0.174952971931818 no 570 0.187757699268128 1003 4259299 SGTC_654 1124-0271 80.9 µM 0.885972542634507 0.175008225925999 no 571 0.187816161605362 928 5403748 SGTC_3334 9142812 21.919 µM 0.885203414389962 0.175204156897023 no 572 0.188023465571409 886 45283678 SGTC_221 trifluoperazine 10.304 µM 0.883400305738864 0.175664033511994 no 573 0.188510012826696 1049 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1304 1165-0502 251 µM 0.881725817817751 0.176091790134328 no 574 0.18896254793192 948 767425 SGTC_1974 st069448 26.9 µM 0.88069792516913 0.176354696984643 no 575 0.189240670049436 933 6323587 YNR016C ACC1 SGTC_3096 9117468 49.47 µM 0.877319061339587 0.177220666828119 no 576 0.19015668087225 832 41316311 SGTC_2756 carbadox 75.1 µM 0.876657912564968 0.177390426446575 no 577 0.19033623665895 896 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2736 butenafine 14.65 µM 0.874178603782399 0.17802793919439 no 578 0.191010498097811 965 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_392 N-ethylmaleimide 8.33 µM 0.873049094597681 0.178318851936421 no 579 0.19131815934872 910 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3119 9125183 49.47 µM 0.872309038622855 0.1785096206998 no 580 0.191519904023104 801 22695334 SGTC_3089 9117425 49.47 µM 0.871896977270487 0.178615895973612 no 581 0.191632291429523 860 9401657 SGTC_1743 st037606 46.3785 µM 0.869831336387852 0.179149248386031 no 582 0.192196291877651 920 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_464 bw-b 70c 158 µM 0.868674498489566 0.179448383304889 no 583 0.192512596817599 983 5353454 SGTC_298 1391-0729 10 µM 0.868308637036692 0.179543053005837 no 584 0.192612697587885 934 3237558 SGTC_891 0929-0073 133 µM 0.868149150203461 0.179584331376184 no 585 0.192656343609235 961 5603632 SGTC_919 tnp00227 403.569 nM 0.864495973742487 0.18053147873325 no 586 0.193657745580867 964 1269246 A methoxyflavone. YNL221C POP1 SGTC_156 3474-0145 5.642 µM 0.864034637413358 0.180651310348733 no 587 0.193784431576132 946 2265471 SGTC_1907 st060210 83.7 µM 0.863360182240922 0.180826589091853 no 588 0.19396973230507 1024 688793 SGTC_2282 7944268 200 µM 0.862683976129716 0.181002429851504 no 589 0.194155622441558 962 2970414 SGTC_3157 9099274 49.47 µM 0.862383548072938 0.181080587581693 no 590 0.194238245395447 948 17217662 SGTC_61 0978-8327 98.565 µM 0.860621537057058 0.181539408335739 no 591 0.194723260084126 1027 6150059 YHR072W ERG7 SGTC_255 tunicamycin 200.472 nM 0.859814403700669 0.181749825474637 no 592 0.194945679060827 951 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_618 k072-0232 33.2 µM 0.855836369493776 0.182789114281793 no 593 0.196044147492871 933 5872756 YGL099W LSG1 SGTC_1491 4138-0063 26.5 µM 0.854197769932355 0.183218286325551 no 594 0.196497709310247 961 23883227 SGTC_3114 9122766 49.47 µM 0.853371987947113 0.183434808089158 no 595 0.196726525255447 867 17176985 SGTC_592 k241-0073 46.5 µM 0.851956084979668 0.183806431855423 no 596 0.197119233207295 1011 4230158 SGTC_3205 9113483 49.47 µM 0.851415187402369 0.183948521785903 no 597 0.197269379062825 961 17018033 SGTC_3216 9129716 49.47 µM 0.850719345201748 0.184131415127589 no 598 0.197462637167757 910 8056934 SGTC_2044 5102272 200 µM 0.850371567435865 0.184222866533524 no 599 0.197559269303183 897 592666 SGTC_516 3992-2719 87.3 µM 0.849013157091926 0.184580343965383 no 600 0.197936985578922 1000 5350887 YDR037W KRS1 SGTC_1220 1838-0075 193 µM 0.847924591518881 0.184867120538045 no 601 0.198239984079876 966 5529645 SGTC_834 0312-0008 75.7 µM 0.847684721986215 0.184930350050393 no 602 0.198306788567598 963 6385573 YIL048W NEO1 SGTC_667 1498-1044 59 µM 0.847176684113699 0.185064312995886 no 603 0.198448323712842 998 6739982 SGTC_2870 9038528 12.99 µM 0.845144832652116 0.185600688128911 no 604 0.199014989738304 884 6463316 SGTC_3242 9133940 49.47 µM 0.841314915398841 0.186614342475459 no 605 0.200085768478176 1017 17248444 SGTC_1481 3346-2004 36 µM 0.840748564871094 0.186764527402465 no 606 0.200244403715589 1019 2770522 SGTC_1617 st002906 78 µM 0.839387090991533 0.187125869255328 no 607 0.200626062735973 991 5150859 SGTC_1079 idarubicin 2.36 µM 0.838555567010002 0.187346772343243 no 608 0.200859376728163 963 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1989 st071868 50.2 µM 0.835409010479229 0.188184146493645 no 609 0.201743729137654 1031 16414057 SGTC_3270 9137563 49.47 µM 0.83492550833145 0.188313022420579 no 610 0.201879825753655 941 17015724 SGTC_674 0498-0004 451 µM 0.834896916818524 0.188320645100183 no 611 0.201887875439163 942 4231473 SGTC_1394 3474-0001 65.7 µM 0.834866178316972 0.188328840392966 no 612 0.201896529804515 882 5017666 YIL048W NEO1 SGTC_1005 4092-0690 4.4 µM 0.832995563441104 0.188827985185858 no 613 0.202423615708075 941 1529343 SGTC_331 k048-0133 24.5 µM 0.832252570266409 0.189026467479677 no 614 0.202633198091405 953 6813582 SGTC_1835 st008666 49.2 µM 0.826230750303751 0.190639866662076 no 615 0.204336603897543 900 690455 SGTC_2985 9022375 71.43 µM 0.82612553159182 0.1906681323691 no 616 0.204366442933296 1029 4939335 SGTC_2769 toremifene 3.73 µM 0.825970502609301 0.19070978367672 no 617 0.204410412419001 977 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1631 benzylvanillin 81.9 µM 0.825839611084203 0.190744954372174 no 618 0.20444754039712 976 75506 SGTC_1620 st003704 16.5 µM 0.825113986136495 0.190940002775285 no 619 0.204653440016955 1005 2834414 SGTC_2610 ononetin 44.17 µM 0.823555330707481 0.191359383705855 no 620 0.205096132979936 983 259632 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.822455353944497 0.191655689376101 no 621 0.20540889321905 1054 688788 SGTC_1464 k208-0027 110 µM 0.822357097176608 0.191682170906516 no 622 0.205436844683665 1010 X1464 SGTC_1574 spiramycin 23.7 µM 0.820213402405595 0.192260483327798 no 623 0.206047231463477 1049 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1026 k007-1105 30.6 µM 0.818022608482525 0.192852603198454 no 624 0.206672138893395 1014 7066794 SGTC_2517 totarol 10 µM 0.817980135384398 0.192864093670673 no 625 0.206684265103506 992 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1293 1000-1278 195 µM 0.81674257085199 0.193199082151224 no 626 0.207037778823098 1029 678847 SGTC_19 0279-0214 38.434 µM 0.813625003129798 0.194044529643779 no 627 0.207929904867703 1123 3566274 YBR002C RER2 SGTC_2704 st078022 71.1 µM 0.812560908068167 0.194333614849747 no 628 0.208234926098432 1037 54697681 SGTC_1771 st048882 4.1505 µM 0.81203568725027 0.19447639943071 no 629 0.20838557711002 1041 4580403 SGTC_1962 st076595 64.5 µM 0.812012887888084 0.194482599026438 no 630 0.20839211819013 1032 279619 SGTC_2396 5342950 42.78 µM 0.811156221032358 0.194715630789371 no 631 0.208637981522419 1018 1886677 SGTC_3349 9149703 23.001 µM 0.80933493552338 0.195211623667518 no 632 0.209161258189902 1049 4910494 SGTC_1773 st048542 73.5835 µM 0.805034405771739 0.1963858351696 no 633 0.210399912882305 985 3237138 SGTC_1217 1183-1422 255 µM 0.804540477243445 0.196520970362439 no 634 0.210542451202523 1083 2849664 SGTC_663 1486-0733 13.9 µM 0.802032582471297 0.19720798074585 no 635 0.211267055488429 1028 722445 YPR165W RHO1 SGTC_1506 4226-2149 212 µM 0.801949902137237 0.197230654834357 no 636 0.211290969110687 1072 991114 SGTC_106 0092-0003 11.579 µM 0.801463196119068 0.197364160078925 no 637 0.211431771167242 1007 1072148 SGTC_1186 1319-0216 26 µM 0.799509086873329 0.197900729415145 no 638 0.211997639893043 1092 4565136 SGTC_2862 9027634 71.43 µM 0.796422378565303 0.198750086785492 no 639 0.212893287640694 994 5012562 SGTC_2623 humulene 100 µM 0.794845023769921 0.199184968532512 no 640 0.213351828534627 939 6187145 An anti-inflammatory. SGTC_1704 st028805 70.8 µM 0.794408099622323 0.199305531209385 no 641 0.213478945211766 1029 2876101 SGTC_2841 9004761 38.96 µM 0.79363789813361 0.199518163755254 no 642 0.213703131500095 1023 2991039 SGTC_183 3914-0051 30.55 µM 0.792023850393146 0.199964202896934 no 643 0.214173384786247 1051 1596232 SGTC_2143 5623677 140.463 µM 0.791601684696279 0.200080966461942 no 644 0.214296482150087 1039 5375313 SGTC_571 k831-0106 44.2 µM 0.79022614050223 0.20046170189415 no 645 0.214697856181002 1012 4783639 SGTC_179 1273-0063 6.77 µM 0.789917203587937 0.200547272020296 no 646 0.214788061819575 1041 3108139 SGTC_2545 solidagenone 89.61 µM 0.786875083787562 0.20139105689077 no 647 0.215677497269325 877 6708572 An anti ulcer agent SGTC_206 4546-0025 72.014 µM 0.786856350530618 0.201396259468679 no 648 0.215682980985629 1108 6620745 YIL048W NEO1 SGTC_2479 5617353 43.85 µM 0.786520188497699 0.201489631681321 no 649 0.215781398180445 1042 2731746 SGTC_1633 st005664 67.9 µM 0.784489863363259 0.202054125109658 no 650 0.216376363758637 1110 2063822 SGTC_2700 st077718 96.8 µM 0.784467423488491 0.202060369374983 no 651 0.216382944830279 1014 904970 SGTC_1055 3448-0672 86 µM 0.78375960931428 0.202257389610689 no 652 0.216590589032526 1020 748378 SGTC_468 gf-109203x 121 µM 0.781230675778473 0.202962257009851 no 653 0.217333417389794 982 2396 A protein kinase C inhibitor. SGTC_3105 9121040 49.47 µM 0.780897390718109 0.203055259910095 no 654 0.217431423430232 885 41448907 SGTC_2790 5423970 71.43 µM 0.779872869650289 0.203341310899612 no 655 0.217732854542124 1080 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1486 3970-0793 4.53 µM 0.779685597911556 0.203393624010858 no 656 0.217787979046889 1094 2844330 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.779568888630158 0.203426230031327 no 657 0.217822337161212 939 6708630 An antioxidant. SGTC_835 0312-0010 67.2 µM 0.779536591771547 0.203435253618055 no 658 0.217831845604759 1037 1626196 SGTC_1194 1488-0194 225 µM 0.778799213817528 0.203641338422872 no 659 0.218049000463975 1062 1391452 SGTC_612 0302-0167 22.4 µM 0.777850678267794 0.203906621230701 no 660 0.218328523821992 1117 235821 SGTC_2891 9063876 19.48 µM 0.777559002149199 0.20398823747887 no 661 0.218414519157795 1026 6472478 SGTC_1280 0880-0253 10.1 µM 0.775554682569261 0.204549608553824 no 662 0.219005983297858 1052 6836607 SGTC_3224 9130643 49.47 µM 0.774048093977554 0.204972179401463 no 663 0.219451175452217 1077 17644395 SGTC_1923 st058458 19.1 µM 0.773342725283334 0.205170200797762 no 664 0.219659788231256 1123 3534982 SGTC_2729 fluphenazine 10.66 µM 0.77278388303524 0.205327167829901 no 665 0.219825146633825 1075 3372 An atypical antipsychotic. SGTC_1742 st038235 28.8875 µM 0.772587958297271 0.205382215851291 no 666 0.219883136617228 1034 564103 YBR002C RER2 SGTC_217 ketoconazole 989 nM 0.767651403956924 0.206772106193983 no 667 0.221347157204613 1053 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1019 4262-0212 3.4 µM 0.767376417290904 0.206849692269162 no 668 0.221428872832983 1176 4677213 SGTC_3042 9091578 49.47 µM 0.767051747958781 0.20694131823338 no 669 0.221525374469359 1052 25236497 SGTC_506 n9-isopropylolomoucine 153 µM 0.766744219400273 0.207028128991851 no 670 0.221616803510304 1084 6610355 SGTC_2057 5236571 38.335 µM 0.766695657848158 0.207041839168562 no 671 0.22163124295741 1099 54684039 YBR257W POP4 SGTC_2591 skatole 100 µM 0.75934752440529 0.209122590719032 no 672 0.223822347732617 1092 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3054 9094397 49.47 µM 0.756805968225747 0.209845132487404 no 673 0.2245830583484 1120 2598354 SGTC_1292 0kpi-0043 232 µM 0.755684593045343 0.210164395458312 no 674 0.224919161809626 1069 3333905 SGTC_410 α-linolenic acid 100 µM 0.755376941860622 0.210252035646048 no 675 0.225011422182426 1117 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1325 1431-0015 227 µM 0.752437093601692 0.211090588189449 no 676 0.225894123303487 1063 1103340 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.751847835763269 0.21125890165134 no 677 0.226071285585671 1126 6312947 SGTC_517 1365-0151 113 µM 0.751587915310252 0.211333169365688 no 678 0.226149456467075 1104 768657 SGTC_1 0258-0098 57.368 µM 0.749951774195624 0.211801019029365 no 679 0.226641875234395 1011 6790032 YDR047W HEM12 SGTC_2077 5212015 200 µM 0.745570604185592 0.213056781662634 no 680 0.227963422908914 1063 780900 SGTC_295 k015-0027 31 µM 0.744652389637799 0.213320516454002 no 681 0.228240944005842 1101 3887424 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.744101991708388 0.213478696069772 no 682 0.228407387234925 1115 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2536 dehydroabietamide 32.04 µM 0.743072372683259 0.213774783171483 no 683 0.228718932497401 1137 3983547 SGTC_2324 6149169 200 µM 0.741544949131145 0.214214463994738 no 684 0.229181544174221 1074 2888231 SGTC_1564 D-Arginine 115 µM 0.74111782381762 0.214337509426634 no 685 0.229311001694107 1108 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1719 st032227 49.2 µM 0.740863619827633 0.214410759527775 no 686 0.22938806790203 1171 3125804 SGTC_2105 5350118 200 µM 0.740513258954534 0.21451174155177 no 687 0.229494309472899 1147 2133313 SGTC_1818 st052136 56.3 µM 0.739002696875538 0.214947436600526 no 688 0.229952679872076 1053 674169 SGTC_2298 7976326 193.81 µM 0.738623177322418 0.215056983067611 no 689 0.230067923144331 1049 2235818 SGTC_1758 st042942 75.2445 µM 0.738237529640316 0.215168331587555 no 690 0.230185060354305 1124 669317 SGTC_1210 3013-0140 750 nM 0.737965063970207 0.215247021099014 no 691 0.230267839596193 1157 905973 SGTC_2174 5790901 200 µM 0.737792573374886 0.215296845917909 no 692 0.230320253484793 1127 786020 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.737236097727249 0.215457632462819 no 693 0.230489392537422 1157 676296 Flavone; oxidizing agent. SGTC_1965 Pectolinarigenin 58.4 µM 0.736765811038618 0.215593570097 no 694 0.230632388835701 1158 5320438 An anti-inflammatory. SGTC_1788 fluconazole 20 µM 0.736088319965621 0.215789488121073 no 695 0.230838475220158 1089 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1060 3448-7350 82 µM 0.736072956387945 0.215793932182933 no 696 0.230843149867552 1091 570178 SGTC_346 4513-0042 7.16 µM 0.734143750068014 0.21635239498849 no 697 0.231430565842339 1107 2827372 SGTC_1343 1487-0095 224 µM 0.732632794361839 0.216790367016606 no 698 0.231891211860481 1141 4560101 YGL055W OLE1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.731920985680998 0.216996872413434 no 699 0.232108398245886 1119 390807 SGTC_102 gallobenzophenone 83.616 µM 0.731806049308744 0.217030227678185 no 700 0.232143478136626 1142 70837 SGTC_2445 5742597 35.57 µM 0.731291475476342 0.217179596592188 no 701 0.232300568109051 1090 1774255 SGTC_299 1273-0059 1.44 µM 0.731216667350894 0.217201316608666 no 702 0.232323410583477 1099 2848077 SGTC_1118 chelidonine 707.474 nM 0.731085782530742 0.217239321119628 no 703 0.232363378942256 1179 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_466 geldanamycin 89.2 µM 0.730526884762044 0.217401649280803 no 704 0.232534092847402 1034 5288382 HSP90 inhibitor. SGTC_1368 1852-0141 284 µM 0.72967244331514 0.217649951474299 no 705 0.232795214570299 1114 2838987 SGTC_2248 tofa 1.1 µM 0.729230362201286 0.217778485236272 no 706 0.232930380775285 1078 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2796 7949634 45.45 µM 0.728553175976853 0.217975459988553 no 707 0.233137514823671 1118 2971588 SGTC_3261 9137475 49.47 µM 0.728093867910869 0.218109118450765 no 708 0.233278063662965 1009 17027690 SGTC_2086 5274770 176.623 µM 0.727712322258236 0.218220183992338 no 709 0.233394852853081 1131 689278 SGTC_1050 3232-1156 69.3 µM 0.727647539296604 0.21823904514128 no 710 0.233414685810239 1098 700529 SGTC_3018 9082602 49.47 µM 0.727436553123135 0.218300478940162 no 711 0.233479284579193 1155 17332089 SGTC_1406 3909-7906 11.9 µM 0.72654664469587 0.218559707212787 no 712 0.233751861710717 1167 X1406 SGTC_344 k064-0035 6.43 µM 0.724641709117416 0.21911520590511 no 713 0.23433593204461 1131 5088750 SGTC_2918 7977171 22.06 µM 0.724381847285701 0.219191047146353 no 714 0.234415670572496 1127 2236483 SGTC_1001 4048-4355 44.4 µM 0.724233007954337 0.219234493025387 no 715 0.234461348639694 1154 21824233 SGTC_3351 9150312 21.596 µM 0.722952765355491 0.219608397418232 no 716 0.234854452153365 1141 4904905 SGTC_2064 5220758 200 µM 0.721765118451333 0.219955585765529 no 717 0.235219449270482 1194 788518 SGTC_2389 9091542 195.52 µM 0.721112783854199 0.220146418605045 no 718 0.235420063136177 1116 3626624 YOL127W RPL25 SGTC_2237 6667747 47.222 µM 0.721041661050658 0.220167230486942 no 719 0.235441941392828 1095 729940 YDL015C TSC13 SGTC_2151 5563267 85.4165 µM 0.718182466875983 0.221004818935379 no 720 0.236322393600875 1147 5310824 SGTC_925 2064-1272 59.6 µM 0.718002346242166 0.221057645481949 no 721 0.236377920075553 1110 6815817 SGTC_1666 st014829 29 µM 0.717382569177194 0.221239471538632 no 722 0.23656903597891 1199 3858230 SGTC_1722 st034304 3.6505 µM 0.716686516843601 0.221443776675735 no 723 0.236783773626338 1185 4036148 YLR033W RSC58 SGTC_3177 9107506 49.47 µM 0.716454875545608 0.221511791895754 no 724 0.236855260563089 1115 8897194 SGTC_50 0929-0078 56.389 µM 0.715596250190127 0.22176400821882 no 725 0.237120344848887 1068 1377751 SGTC_624 k048-0052 28 µM 0.714997688129447 0.22193992942999 no 726 0.237305235910555 1121 6835531 SGTC_2776 terbinafine 19.92 µM 0.714608099024604 0.222054474956296 no 727 0.237425619410732 1184 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1679 SEC14.276 6.7 µM 0.7142221851681 0.222167973165208 no 728 0.237544900301822 1207 1005053 YMR079W SEC14 SGTC_432 NS 1619 61.3 µM 0.713423498434968 0.222402974020804 no 729 0.237791868289634 1135 4552 A K+/calcium channel activator. SGTC_343 4130-2827 29.8 µM 0.713246350700081 0.222455116125932 no 730 0.237846664561153 1191 1118244 SGTC_1035 k081-0041 55.2 µM 0.711841028618256 0.222869009078517 no 731 0.238281611466376 1200 731709 SGTC_2629 bisabolol 100 µM 0.711415891712643 0.222994306026117 no 732 0.238413277040489 1162 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1234 0326-0494 15.5 µM 0.710867925593579 0.223155862538632 no 733 0.238583041766187 1171 1547813 SGTC_916 4466-0038 42 nM 0.709817411122782 0.223465771327478 no 734 0.238908685318746 1229 5722064 YGL116W CDC20 SGTC_1424 4048-1941 275 µM 0.708735062573308 0.223785327311044 no 735 0.23924445101846 1220 X1424 SGTC_801 0866-0028 10.1 µM 0.708591319034791 0.223827786135394 no 736 0.239289062463287 1212 6849771 SGTC_2834 9001755 58.44 µM 0.707877118942007 0.224038813731499 no 737 0.239510785000278 1084 2989575 SGTC_1955 wogonin 32.4 µM 0.706154638349238 0.224548226782911 no 738 0.240045988161046 1196 5281703 A flavanone. SGTC_1967 st070177 51.4 µM 0.70614440420008 0.22455125543223 no 739 0.24004917002756 1208 5729214 SGTC_1714 st033236 13.627 µM 0.706119101924777 0.224558743376346 no 740 0.240057036775581 1205 2916566 SGTC_1244 0416-0015 52.5 µM 0.703580876100026 0.2253106243632 no 741 0.240846912166475 1177 96201 SGTC_1379 2144-0755 36.5 µM 0.703495441738651 0.225335956765711 no 742 0.240873523225281 1224 5392327 SGTC_1692 fluoroquinolonic acid 71 µM 0.702404024727104 0.225659718016999 no 743 0.241213618031138 1195 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1820 st053765 18.6 µM 0.701300308781955 0.225987395155068 no 744 0.241557810535557 1174 3690829 SGTC_1850 st056238 17 µM 0.699752845329501 0.22644726707814 no 745 0.242040833916644 1206 5393177 SGTC_989 1501-0895 10.3 µM 0.698723459620047 0.226753470199336 no 746 0.242362435014815 1184 2830112 SGTC_155 k072-0202 43.6 µM 0.696008571245048 0.227562165889357 no 747 0.243211730994115 1144 5857737 SGTC_3139 9095020 49.47 µM 0.694466016579605 0.228022375981185 no 748 0.243695002762468 1026 25236292 SGTC_994 3910-0338 138 µM 0.693870878867008 0.228200070883001 no 749 0.243881593821246 1250 3479481 SGTC_3310 9130229 44.1445 µM 0.693027877876586 0.228451905440061 no 750 0.2441460283161 1193 7761258 SGTC_552 k242-0005 476 µM 0.692151588446981 0.228713849880233 no 751 0.244421068611694 1209 4088318 SGTC_1106 tegaserod maleate 11.7 µM 0.691847379552431 0.228804824810976 no 752 0.244516589451392 1218 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1309 pyrazolanthrone 13.4 µM 0.691439218235094 0.228926919049552 no 753 0.244644782679294 1229 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2866 9034245 58.44 µM 0.691433904163758 0.228928508901064 no 754 0.244646451934394 1197 6462273 SGTC_2012 4023501 200 µM 0.690786292567417 0.229122306214819 no 755 0.244849925480511 1179 3477460 SGTC_1766 st045414 44.774 µM 0.690719341995872 0.229142346373017 no 756 0.244870965921525 1256 253960 SGTC_3283 9109332 35.8195 µM 0.69032418444364 0.229260647982797 no 757 0.244995171224101 1096 17027281 SGTC_57 miconazole 162.5 nM 0.689442619664308 0.229524692757279 no 758 0.245272385393554 1154 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1948 st076329 66.6 µM 0.688850336239134 0.229702188131209 no 759 0.245458727693398 1117 24208413 SGTC_574 1315-0397 40 µM 0.688682410896038 0.229752525947273 no 760 0.245511573660541 1250 6794277 SGTC_3039 9090270 49.47 µM 0.688261150337953 0.229878831486876 no 761 0.245644170906979 1201 17173750 SGTC_3317 9138495 8.753 µM 0.6878392582611 0.230005365322637 no 762 0.245777005469131 1207 17020139 SGTC_2003 4023581 200 µM 0.687702664935959 0.230046340732275 no 763 0.245820020736176 1219 16641307 SGTC_2150 5556613 200 µM 0.687601345160612 0.230076737383798 no 764 0.2458519304488 1214 743190 SGTC_385 1494-0393 12.4 µM 0.687182372489047 0.230202456015591 no 765 0.245983905562726 1212 3090647 SGTC_2367 9070478 135.38 µM 0.686189894460275 0.23050041624649 no 766 0.246296684727355 1176 572802 SGTC_1207 2099-0101 141 µM 0.686113122828428 0.230523473486558 no 767 0.246320888165985 1233 5837381 SGTC_1454 4239-0054 42.6 µM 0.685696167598957 0.230648722419069 no 768 0.246452361983369 1290 1340767 SGTC_2466 5983409 37.09 µM 0.68328596408843 0.23137346664348 no 769 0.2472130807985 1186 2879657 SGTC_3118 9124250 49.47 µM 0.683085995289323 0.231433653934957 no 770 0.247276252173693 1138 1504786 SGTC_150 3970-0969 77.2 µM 0.681955519176835 0.231774072623308 no 771 0.247633538790468 1238 6615640 SGTC_774 k060-0086 136 µM 0.678621157356978 0.232779767364994 no 772 0.248688966829702 1254 5911235 SGTC_1573 oleylamine 1.06 µM 0.678182197069237 0.232912344920779 no 773 0.248828089490098 1244 5356789 An amine of the fatty acid oleic acid. SGTC_3235 9132602 49.47 µM 0.676198782918501 0.233511910804274 no 774 0.249457222599821 1257 4912240 SGTC_2935 9038016 29.96 µM 0.675946103500247 0.233588354642939 no 775 0.249537432428128 1217 6463195 SGTC_604 1000-0114 314 µM 0.675629594164497 0.233684128706828 no 776 0.249637923571122 1258 1572745 SGTC_1731 st035964 63 µM 0.674923419577797 0.233897891880011 no 777 0.249862210187645 1212 6739575 SGTC_2315 7733312 200 µM 0.674700417406826 0.233965418442386 no 778 0.249933059652274 1208 726316 SGTC_3183 9108214 49.47 µM 0.674490759476595 0.234028914127159 no 779 0.249999679274407 1144 4974831 SGTC_1829 berberine 14.4 µM 0.673788571828948 0.234241643770337 no 780 0.250222870737912 1253 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1008 4106-0037 6 µM 0.672508892962207 0.234629601092931 no 781 0.250629890305377 1209 2905394 SGTC_2391 6285546 200 µM 0.670775959338066 0.235155536578181 no 782 0.251181632341765 1214 846083 SGTC_1183 1254-0324 198 µM 0.67041095806845 0.23526639533575 no 783 0.251297925531758 1252 5799357 SGTC_2358 9037157 4 µM 0.670176708850691 0.235337557073751 no 784 0.251372574756278 1250 2388925 SGTC_2429 5902844 64.44 µM 0.669192894391481 0.235636556276764 no 785 0.251686219168593 1253 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1000 4048-0884 8.67 µM 0.669132002311171 0.235655069376679 no 786 0.251705638623574 1236 13040088 SGTC_1203 3992-3522 103 µM 0.668851607287974 0.235740328598928 no 787 0.251795071275861 1384 5322312 SGTC_197 4544-0043 41.561 µM 0.667612265154169 0.236117376853551 no 788 0.252190563233226 1235 896523 SGTC_1185 1319-0113 81.3 µM 0.666509343930092 0.236453200608459 no 789 0.252542796616723 1259 4672763 SGTC_2488 5268135 45.7 µM 0.666183245830472 0.236552543152491 no 790 0.252646990250073 1242 1270356 YLR208W SEC13 SGTC_798 1287-0182 476 µM 0.665938554975119 0.236627100868415 no 791 0.25272518781459 1271 1649755 SGTC_2462 5162487 171.77 µM 0.665365333160556 0.236801813128472 no 792 0.252908426199807 1209 2259986 SGTC_163 TUB2.036 7.546 µM 0.665229634032945 0.236843183243237 no 793 0.25295181456116 1261 15992207 YJR013W GPI14 SGTC_873 0591-4978 488 µM 0.664966624061996 0.236923377480337 no 794 0.253035920371105 1323 3305145 SGTC_1885 st057546 99.9 µM 0.660648247340198 0.238242223867421 no 795 0.2544189600677 1300 702008 SGTC_2531 methyl deoxycholate 70.07 µM 0.660398396938172 0.238318651880553 no 796 0.25449910032234 1234 16667744 Haematoxylin. SGTC_245 methotrexate 289.6 µM 0.658300164584002 0.238961020498334 no 797 0.255172636128826 1264 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3219 9131112 49.47 µM 0.654547671067652 0.240112193859021 no 798 0.256379512499167 1208 17612988 YMR079W SEC14 SGTC_1971 st069429 63.5 µM 0.654444366605385 0.240143927844924 no 799 0.256412779286423 1256 1246522 YGL099W LSG1 SGTC_2919 7978188 46.38 µM 0.654220761507969 0.240212624681385 no 800 0.256484793783818 1245 2980291 SGTC_142 0335-0849 62.6745 µM 0.651960742188399 0.240907557475095 no 801 0.257213249051468 1297 3889043 YPR107C YTH1 SGTC_1135 dihydrocapsaicin 536.708 nM 0.651030676761359 0.241193860378198 no 802 0.257513342239036 1225 107982 A Capsaicinoid. SGTC_1296 1068-0102 11.9 µM 0.650637241426965 0.241315027583442 no 803 0.257640342070807 1235 767053 SGTC_1232 0279-0259 161 µM 0.650495731035895 0.241358616957639 no 804 0.257686029182548 1281 1560000 SGTC_2301 7769476 200 µM 0.650392415725769 0.241390443821866 no 805 0.257719387538548 1283 977820 SGTC_2715 st079500 56.4 µM 0.649928614836461 0.241533348390261 no 806 0.257869166775457 1228 28246688 SGTC_2421 5690543 90.72 µM 0.649437058987421 0.241684854846131 no 807 0.258027958451505 1295 3397993 SGTC_1480 1070-0044 41.2 µM 0.649142693513914 0.241775608331516 no 808 0.258123074232372 1273 3124987 SGTC_1399 3562-5772 25 µM 0.648722237168226 0.241905267961453 no 809 0.258258964193519 1231 23847490 SGTC_2158 5657123 3.6195 µM 0.648144290773456 0.242083555657877 no 810 0.258445814861629 1250 2858827 SGTC_3069 9117009 49.47 µM 0.648053198657137 0.242111662692802 no 811 0.25847527142461 1164 41904981 SGTC_538 2922-0838 53.3 µM 0.64791609446736 0.242153970372675 no 812 0.258519610243283 1306 777039 SGTC_2274 7947094 46.08 µM 0.647204898989773 0.242373495737266 no 813 0.258749670550864 1273 2971028 SGTC_3150 9097574 49.47 µM 0.646173699043059 0.24269198860571 no 814 0.25908343527174 1260 17217476 SGTC_376 3970-0862 59.1 µM 0.645247903216332 0.242978119624992 no 815 0.259383273757077 1258 3135186 SGTC_2088 5278280 127.392 µM 0.643987706891654 0.243367895189172 no 816 0.259791702789459 1300 791502 SGTC_2647 atorvastatin 60.16 µM 0.643452336729968 0.243533586041748 no 817 0.259965316386862 1280 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2551 apiole 73.87 µM 0.64261366342643 0.243793268137404 no 818 0.260237407496668 1178 10659 A possible DNA adduct former. SGTC_3012 9080433 71.4286 µM 0.641687605131796 0.244080181172562 no 819 0.260538019351291 1287 17688859 SGTC_1673 st016611 27.3 µM 0.640865531379873 0.244335030039414 no 820 0.260805026049573 1332 5226799 SGTC_1177 0983-0204 23.6 µM 0.640167997261218 0.244551383130401 no 821 0.261031693058684 1304 766818 SGTC_3003 9075612 71.4286 µM 0.639572523288797 0.244736161999316 no 822 0.261225275246169 1278 6501993 SGTC_1405 3909-7894 12 µM 0.639502508805846 0.244757892818248 no 823 0.261248041047525 1301 7104060 SGTC_3186 9110464 49.47 µM 0.637676875753283 0.24532489210037 no 824 0.261842020704345 1303 17018021 SGTC_3353 9151644 39.2805 µM 0.637173393615287 0.245481386087474 no 825 0.262005953128522 1286 4909158 SGTC_1094 duloxetine 25.4 µM 0.6368250652961 0.24558968603241 no 826 0.262119398672787 1284 60834 A selective serotonin reuptake inhibitor. SGTC_3305 9127027 53.8275 µM 0.636265163707398 0.245763820709182 no 827 0.26230180333751 1239 41905295 SGTC_1664 st014217 9.02 µM 0.635661322270369 0.245951695362896 no 828 0.262498595562471 1334 3982782 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.63481074354551 0.246216468670097 no 829 0.262775927747229 1443 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_64 000l-0018 272.079 µM 0.633757527463332 0.246544531839528 no 830 0.263119537630721 1265 6811119 SGTC_2831 7999036 19.48 µM 0.633755858517865 0.246545051880195 no 831 0.263120082303355 1337 2988270 SGTC_2382 9035899 200 µM 0.633049691375197 0.246765145121322 no 832 0.263350596827554 1303 6462679 SGTC_2938 9059746 27.26 µM 0.632985764639963 0.246785074550734 no 833 0.263371469555217 1268 6471769 SGTC_1430 4049-0248 69.1 µM 0.632087541772459 0.247065190412222 no 834 0.263664837720604 1341 22774488 SGTC_16 erodoxin 22.806 µM 0.631778875124051 0.247161489098563 no 835 0.263765689666711 1314 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3326 9140064 16.379 µM 0.630888197426326 0.247439477722534 no 836 0.264056814763592 1266 1868434 SGTC_383 2324-0395 7.37 µM 0.630035212180312 0.247705858740676 no 837 0.264335773178074 1316 3146421 SGTC_263 alizarin 107.927 µM 0.629437072794906 0.247892744576925 no 838 0.264531476816479 1300 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_107 0358-0022 2.6945 µM 0.627776701749398 0.248411913853192 no 839 0.265075115295719 1325 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_59 0330-0160 1.33 µM 0.627652312375837 0.248450831576859 no 840 0.26511586568817 1293 4293482 SGTC_1946 st076057 65.1 µM 0.627160069925333 0.248604871418346 no 841 0.265277157234962 1203 953009 SGTC_2320 7373003 200 µM 0.626359503594433 0.248855505176082 no 842 0.265539582654672 1281 5415828 SGTC_2157 5649910 96.377 µM 0.625195392397556 0.24922019399348 no 843 0.265921412805705 1271 2858091 SGTC_876 0720-0963 56.8 µM 0.624332494810243 0.249490702931896 no 844 0.266204623881005 1363 765861 SGTC_1344 1488-0097 29.1 µM 0.623597991329557 0.249721084593864 no 845 0.266445815055753 1312 747966 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.622578600127129 0.250041010193414 no 846 0.266780738772902 1333 4213774 SGTC_2303 7774051 200 µM 0.621457590269511 0.250393078681639 no 847 0.267149295041367 1346 2953184 SGTC_2295 7971645 200 µM 0.621329823601622 0.250433222226411 no 848 0.26719131741114 1341 2978226 YKL099C UTP11 SGTC_1498 4478-3555 97.6 µM 0.621196092366463 0.250475243456822 no 849 0.26723530509634 1290 3437919 SGTC_1983 st071813 46.9 µM 0.620648208038519 0.250647439501057 no 850 0.267415556666128 1302 11838595 SGTC_809 3998-0021 90 µM 0.619230581868652 0.25109327991187 no 851 0.267882233973832 1262 715485 SGTC_1524 corynanthine 62.1 µM 0.61760855900833 0.251603916809856 no 852 0.268416700629858 1362 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_671 0560-0003 407 µM 0.614437907708979 0.252603666986801 no 853 0.269462996222273 1269 3238678 SGTC_3240 9133527 49.47 µM 0.611245827709465 0.253612283813971 no 854 0.270518424216149 1284 17617455 SGTC_2179 6298986 200 µM 0.610845666587629 0.253738873692801 no 855 0.270650878860581 1335 738374 SGTC_2508 celastrol 40.54 µM 0.609490989762949 0.254167668163365 no 856 0.271099521614851 1270 122724 Celastrol is a natural product and antioxidant. SGTC_1382 3002-2117 298 µM 0.607034930813367 0.254946049980562 no 857 0.271913865455333 1378 1497314 SGTC_1717 st033143 58.0435 µM 0.607023865508341 0.254949559651737 no 858 0.27191753707783 1387 674616 SGTC_3153 9100258 49.47 µM 0.606943241850668 0.254975132464368 no 859 0.27194428987608 1281 25236848 SGTC_2097 5376186 200 µM 0.605901266335628 0.25530575474623 no 860 0.272290159255295 1304 742755 SGTC_193 1273-0060 1.558 µM 0.605652496161362 0.255384723472883 no 861 0.272372767387255 1220 2847393 YHR072W ERG7 SGTC_1138 3761-0006 1.03 µM 0.605269523477398 0.255506317918966 no 862 0.272499963947839 1319 12061087 SGTC_3142 9086498 49.47 µM 0.603163468208749 0.256175533990618 no 863 0.273199973862191 1272 25236367 SGTC_1236 0330-0013 258 µM 0.600064407390934 0.257161945016104 no 864 0.274231656037512 1317 4617066 SGTC_3287 9117173 37.0625 µM 0.598319561301071 0.25771818596474 no 865 0.274813363394674 1311 2789709 SGTC_749 1000-0129 128 µM 0.598113357356412 0.257783963136555 no 866 0.274882149082754 1429 708470 SGTC_377 3970-0964 33.1 µM 0.597682115430848 0.2579215535266 no 867 0.275026030555552 1369 16481235 SGTC_2221 6807166 181.081 µM 0.596451357287663 0.258314443922322 no 868 0.275436870092579 1315 674925 SGTC_1492 4158-0558 28.5 µM 0.596119823565165 0.258420331214334 no 869 0.275547591006105 1400 3967268 SGTC_2910 7948405 25.97 µM 0.596102541513189 0.258425851479618 no 870 0.275553363220018 1362 2971328 SGTC_3307 9126885 69.2785 µM 0.595613146551466 0.258582200287066 no 871 0.275716846060127 1311 24824909 SGTC_3292 9120825 59.784 µM 0.59444044678991 0.258957046201628 no 872 0.276108781386933 1366 24824900 SGTC_2564 betulinic acid 100 µM 0.593918952782082 0.259123828638139 no 873 0.276283160978842 1443 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3314 9135860 59.4275 µM 0.593091767029614 0.259388490228276 no 874 0.276559869981483 1341 25252478 SGTC_2211 7117706 200 µM 0.59298238919166 0.259423496582128 no 875 0.276596469067571 1340 822771 SGTC_2329 6138490 200 µM 0.59178821882034 0.259805849262771 no 876 0.276996206625799 1381 720019 SGTC_2310 7668677 200 µM 0.59148845756794 0.259901873261768 no 877 0.277096593336528 1395 2197143 SGTC_765 1319-0117 244 µM 0.590896465298141 0.260091562825403 no 878 0.27729489725013 1314 3487746 YGL099W LSG1 SGTC_892 0929-0076 29 µM 0.586590444530742 0.261473467296373 no 879 0.27873940088314 1337 5751038 SGTC_1855 st056195 39.6 µM 0.58577033337427 0.261737087200514 no 880 0.279014931185221 1387 4028379 SGTC_2650 prasterone 100 µM 0.585301781037574 0.261887761776741 no 881 0.27917240875441 1341 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1554 st069299 38.7 µM 0.584717729825433 0.262075640130139 no 882 0.279368765261646 1357 24207999 SGTC_2944 9067346 25.62 µM 0.584475473782034 0.26215358963413 no 883 0.279450230798422 1345 6473075 SGTC_1358 1509-0022 2.48 µM 0.583837972733836 0.262358771879303 no 884 0.279664663906277 1364 3258434 SGTC_1866 st057638 64 µM 0.581186026639413 0.263213193021188 no 885 0.280557542111295 1373 688802 SGTC_1012 4112-3522 18 µM 0.581176568264634 0.263216242923355 no 886 0.280560729099026 1370 3112398 SGTC_1668 st014914 51.6 µM 0.580819966264186 0.263331244262899 no 887 0.28068089848355 1361 2839556 SGTC_1785 bathophenanthroline 24 µM 0.580271883602179 0.263508046616137 no 888 0.280865642429732 1343 72812 An iron chelator. SGTC_2553 4-methylesculetin 85.09 µM 0.580025516868303 0.263587540160229 no 889 0.280948705186011 1352 5319502 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.579855699020647 0.26364234129852 no 890 0.28100596633066 1480 6728940 SGTC_2706 st078239 82.5 µM 0.579102081264956 0.263885607938909 no 891 0.281260147897865 1360 15434492 SGTC_1630 st005209 31.3 µM 0.578683247256512 0.264020856359194 no 892 0.281401460967882 1384 3367314 SGTC_2415 st077333 57.7 µM 0.577261006242125 0.264480384958185 no 893 0.281881575462899 1538 2766255 SGTC_2657 nystatin 74.44 µM 0.575778745139455 0.26495973891279 no 894 0.282382370943367 1382 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_208 k072-0098 12.366 µM 0.575538765557279 0.265037388309819 no 895 0.28246349047851 1362 5948901 SGTC_872 0588-0139 234 µM 0.574604153057322 0.265339907921147 no 896 0.282779521334898 1368 2047100 SGTC_2080 5212524 12.4 µM 0.574534523960473 0.265362452795968 no 897 0.282803072588309 1383 260183 SGTC_1200 1643-0193 18.4 µM 0.574466539435138 0.265384466120781 no 898 0.282826068493085 1363 5403974 SGTC_2376 9072922 81.32 µM 0.574401841749981 0.265405416030469 no 899 0.282847953451485 1403 17087968 SGTC_381 3461-2219 42.7 µM 0.572788255152733 0.265928186646713 no 900 0.28339403615433 1415 2883159 SGTC_1581 himbacine 57.9 µM 0.572280087126316 0.266092931144528 no 901 0.283566118983279 1352 5281825 An alkaloid muscarinic receptor antagonist. SGTC_169 k015-0017 16.025 µM 0.571871019374892 0.26622558556942 no 902 0.283704679480946 1453 1840002 SGTC_2748 diazoxide 86.69 µM 0.570546773320298 0.266655247817927 no 903 0.28415345382055 1386 3019 A potassium channel activatior. SGTC_2669 eugenol 100 µM 0.570510304041087 0.266667085526281 no 904 0.284165817712694 1391 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1097 itavastatin 7.23 µM 0.569660049892826 0.266943148179373 no 905 0.284454145560955 1390 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_214 4373-3496 70 µM 0.569042595249117 0.267143715345451 no 906 0.284663616833511 1438 3779166 SGTC_2519 cryptotanshinone 88.04 µM 0.568622732487171 0.267280142379203 no 907 0.284806097178842 1399 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_519 k048-0011 62.8 µM 0.56841604478553 0.267347314830107 no 908 0.284876249106432 1411 6836379 SGTC_2375 9072683 200 µM 0.566855029037151 0.267854911908841 no 909 0.285406339929269 1471 16798029 SGTC_2161 5662504 8.5105 µM 0.566419962261165 0.267996469469985 no 910 0.285554163868084 1352 2859334 SGTC_2709 st078560 56 µM 0.566222843927115 0.268060618206846 no 911 0.285621151347581 1466 17250903 SGTC_1678 st019265 80.2 µM 0.565961202910514 0.268145776666983 no 912 0.285710077366322 1465 5367020 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.56459309261632 0.268591288425303 no 913 0.286175282290738 1359 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1769 st044406 64.4 µM 0.564487893769149 0.268625560798809 no 914 0.286211068436337 1398 670903 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.564140887886028 0.26873862623979 no 915 0.286329126649129 1390 7104 SGTC_1453 4237-0541 195 µM 0.564137257404701 0.268739809291257 no 916 0.286330361932331 1377 739892 SGTC_2771 fluoxetine 41.05 µM 0.563780006566363 0.268856238089471 no 917 0.28645193007582 1431 3386 A selective serotonin reuptake inhibitor. SGTC_1764 st044502 93.5 µM 0.562785299810837 0.269180548505047 no 918 0.286790545743514 1361 8407 SGTC_2441 5730946 39.09 µM 0.56269470462933 0.269210095562567 no 919 0.286821395360623 1448 1774275 SGTC_3327 9140648 26.9345 µM 0.562104179545295 0.269402731518631 no 920 0.287022520440946 1407 8029710 SGTC_2976 9009005 19.48 µM 0.561045930848776 0.26974811699779 no 921 0.287383113048879 1489 2993148 SGTC_1891 st059073 26.2 µM 0.560815930666567 0.269823212536774 no 922 0.287461512726227 1461 688754 SGTC_358 0075-0058 9.45 µM 0.558991071093731 0.270419403730712 no 923 0.288083906969172 1476 1069125 SGTC_2642 cholecalciferol 100 µM 0.558359570533332 0.270625871501299 no 924 0.288299437209818 1415 9821465 A vitamin D precursor, similar to steriods. SGTC_956 1185-0240 191 µM 0.555974838155583 0.271406264048782 no 925 0.289114027962389 1415 1416193 SGTC_1306 1185-0270 9.02 µM 0.55541352722632 0.271590113313203 no 926 0.289305921060919 1420 1548076 SGTC_3027 9089541 49.47 µM 0.555109375343525 0.271689759756022 no 927 0.289409925233113 1386 9943819 SGTC_2186 6124449 200 µM 0.554913097973557 0.271754073939524 no 928 0.289477051239203 1413 3834182 YLR033W RSC58 SGTC_2369 9071472 200 µM 0.554629469974713 0.271847023677411 no 929 0.289574063696114 1458 17296037 SGTC_1982 st072467 71.9 µM 0.554600937666299 0.271856375077653 no 930 0.289583823765684 1395 3163533 SGTC_39 0986-0283 58.349 µM 0.554416608727938 0.271916792331446 no 931 0.289646881034738 1488 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1609 st001574 46.4 µM 0.554238784243482 0.27197508395815 no 932 0.289707719296101 1370 3960012 SGTC_788 1182-0090 188 µM 0.553854716224562 0.272101004301638 no 933 0.289839139155462 1547 5715185 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.551601038376027 0.272840477488774 no 934 0.29061086242506 1421 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2836 9010338 19.48 µM 0.549320930717531 0.273589635793091 no 935 0.29139261290286 1281 2994051 SGTC_2742 clothiapine 36.27 µM 0.545835967834868 0.274736627882 no 936 0.292589348395583 1441 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1941 st076221 61.8 µM 0.545798949944604 0.274748824148818 no 937 0.292602072579575 1402 2828568 SGTC_1071 trifluoperazine 6.31 µM 0.54561699601946 0.274808776303076 no 938 0.292664619460253 1492 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_189 3970-0742 2.116 µM 0.545434441434446 0.274868932849286 no 939 0.29272737905905 1438 2891807 SGTC_652 0437-0092 114 µM 0.544743926866695 0.275096534281027 no 940 0.292964824390477 1383 3091274 SGTC_3021 9087658 49.47 µM 0.544436788145979 0.275197800502034 no 941 0.293070468040656 1404 25237042 SGTC_2584 androsterone 48.74 µM 0.543036161720886 0.275659831369983 no 942 0.293552452366323 1441 2754130 A steroid. SGTC_3262 9137218 49.47 µM 0.542996311443048 0.275672982535746 no 943 0.293566171034246 1331 17650664 SGTC_1889 st059080 5.18 µM 0.542637520890005 0.275791402474851 no 944 0.293689699937274 1487 176925 Isolated from Daphnopsis sellowiana. SGTC_866 0495-0101 262 µM 0.542389709123942 0.275873208112646 no 945 0.293775033718447 1367 635694 SGTC_2385 9074692 200 µM 0.540408870340194 0.276527534923405 no 946 0.294457545929059 1397 17046906 SGTC_816 0325-0417 81.3 µM 0.53970781773108 0.276759294492658 no 947 0.294699273868772 1399 68101 SGTC_3152 9099253 49.47 µM 0.538846408743861 0.277044196186796 no 948 0.294996419080673 1420 25236131 SGTC_2757 clomiphene 4.22 µM 0.538022405977191 0.277316860443504 no 949 0.29528079002523 1543 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1105 epirubicin 18.1 µM 0.537822561168113 0.277383009280983 no 950 0.295349777314709 1373 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_535 2293-4129 48.2 µM 0.535164077423662 0.278263703292519 no 951 0.296268202028315 1518 396118 YIL048W NEO1 SGTC_2327 6189656 200 µM 0.534085650796496 0.278621349290488 no 952 0.296641138463752 1544 5349088 SGTC_2640 pentamidine 10.38 µM 0.532164220173931 0.279259120648009 no 953 0.297306130830323 1475 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2852 9023854 51.95 µM 0.531664354511048 0.279425154903639 no 954 0.297479242078847 1500 19798528 SGTC_1193 1488-0126 41.5 µM 0.531653041565447 0.279428913141016 no 955 0.297483160460322 1448 1384710 SGTC_1136 pergolide 1.05886 µM 0.528692144541764 0.280413386417194 no 956 0.298509513710529 1445 47811 A dopamine receptor agonist. SGTC_3133 9127736 49.47 µM 0.527925559439423 0.280668542885799 no 957 0.298775501937139 1486 27243420 SGTC_2569 tetrandrine 100 µM 0.527374985277649 0.280851869775779 no 958 0.298966605542405 1394 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2747 doxorubicin 7.63 µM 0.525014352619058 0.281638554672827 no 959 0.299786606757308 1399 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2625 euphol 100 µM 0.524921105409003 0.281669651268621 no 960 0.299819018476063 1547 6708538 A triterpene alcohol. SGTC_8 0354-0001 70 µM 0.524533896248112 0.281798797630252 no 961 0.299953625150295 1481 4993152 SGTC_43 0570-0105 72.5 µM 0.524519743424147 0.281803518580111 no 962 0.299958545656695 1490 1114046 YDL195W SEC31 SGTC_1739 st037196 92.5 µM 0.524338845690917 0.281863863896463 no 963 0.300021441513068 1516 612214 SGTC_175 3793-3120 23.7 µM 0.522336325229342 0.282532296374448 no 964 0.30071809081338 1434 5322297 SGTC_1274 0865-0114 173 µM 0.522187212320395 0.282582100076671 no 965 0.300769994332088 1464 870624 SGTC_2107 5363541 170.161 µM 0.521028764244094 0.282969165346247 no 966 0.301173366852187 1432 244052 SGTC_1371 2421-0008 32.7 µM 0.520862817878773 0.283024632840416 no 967 0.301231169457138 1471 2827552 SGTC_366 0181-0206 4.31 µM 0.519722459744321 0.283405938099281 no 968 0.301628515226564 1585 274874 SGTC_1115 galangin 695.678 nM 0.518537138618793 0.28380253862521 no 969 0.302041777550687 1485 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2634 4'-methoxyflavone 100 µM 0.517456614164988 0.284164306246036 no 970 0.302418723895871 1476 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1578 josamycin 24.2 µM 0.517367937654256 0.284194005589851 no 971 0.302449668504016 1392 5282165 A P450 substrate. SGTC_2183 6420625 130.508 µM 0.516828761533748 0.284374617221122 no 972 0.302637850277901 1433 2897619 SGTC_808 0711-0032 135 µM 0.515244744548683 0.284905543612212 no 973 0.303191002771272 1536 4252555 SGTC_541 4513-1321 94 µM 0.514975778996496 0.284995741673284 no 974 0.303284972762243 1406 747515 SGTC_2671 danthron 100 µM 0.513852060262015 0.28537272990392 no 975 0.303677713365233 1435 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2013 4024628 200 µM 0.512209333089268 0.2859242634947 no 976 0.30425225593078 1486 5230760 SGTC_2766 oltipraz 83.91 µM 0.511871282566106 0.286037824313738 no 977 0.304370548882084 1531 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_607 4491-0986 66.8 µM 0.511599343182178 0.286129192066945 no 978 0.304465722629141 1554 698981 YDR232W HEM1 SGTC_1202 1988-0068 29.6 µM 0.510859248826971 0.286377923398949 no 979 0.304724808988126 1408 2850480 SGTC_1331 1472-0049 76.2 µM 0.508151733801177 0.287288740011461 no 980 0.305673468403568 1427 24051409 SGTC_2125 5246583 200 µM 0.506547540086188 0.28782904174489 no 981 0.30623616248667 1575 835267 SGTC_2993 9054257 71.4286 µM 0.504073480332076 0.288663259022717 no 982 0.307104870987152 1444 6470217 YGL055W OLE1 SGTC_659 k018-0002 107 µM 0.502499650373349 0.289194523710166 no 983 0.307658049135268 1541 6797879 YHR007C ERG11 SGTC_1266 0828-0227 32.9 µM 0.502433149608574 0.289216981938367 no 984 0.307681432822983 1519 3913820 SGTC_1600 coumarin 106 71.1 µM 0.501633623495919 0.289487057128567 no 985 0.307962631619254 1527 100336 A hepatotoxic, DNA x-linker. SGTC_400 oxethazaine 37.5 µM 0.500579484825044 0.2898433198595 no 986 0.308333551776383 1467 4621 A local anesthetic. SGTC_2801 7907800 81.82 µM 0.499633064964391 0.290163352432982 no 987 0.308666735677661 1493 6620925 SGTC_1353 1498-1206 8.11 µM 0.499585420971998 0.290179467660607 no 988 0.308683512751688 1483 6756808 SGTC_2689 tacrolimus 100 µM 0.497777211904131 0.290791390723669 no 989 0.309320539729423 1489 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.497588686286177 0.290855225126573 no 990 0.309386989824017 1463 91467 include heat shock SGTC_1461 k072-0203 53.8 µM 0.497517259508546 0.290879411803641 no 991 0.309412167426831 1414 5418714 SGTC_1164 k060-0068 93.7 µM 0.497014411908874 0.291049713654496 no 992 0.309589444154459 1512 5963676 SGTC_1041 0206-0046 107 µM 0.496272254734103 0.29130114871153 no 993 0.309851169379963 1512 50494 SGTC_1776 st049249 45.9 µM 0.492493226292103 0.292583013501178 no 994 0.311185354649817 1450 1822314 SGTC_2486 5283202 22.39 µM 0.491961036716227 0.292763745122727 no 995 0.311373444063574 1452 1377751 SGTC_1893 st059353 36.1 µM 0.489492417307776 0.293602765623787 no 996 0.312246560780379 1452 3112488 SGTC_1440 4100-1550 40 µM 0.488846454936134 0.293822495310871 no 997 0.312475203209606 1513 742806 SGTC_2525 harmine 47.85 µM 0.486220177199896 0.294716628815628 no 998 0.313405533518402 1571 5280953 A monoamine oxidase inhibitor SGTC_857 0438-0306 1.35 µM 0.485960458651645 0.29480511983975 no 999 0.31349760065937 1509 4686136 SGTC_287 k060-0039 29.6 µM 0.485933082751085 0.29481444804069 no 1000 0.313507305768095 1572 5861974 SGTC_547 1120-0019 610 nM 0.485802330036196 0.294859003249964 no 1001 0.313553661067449 1516 3676939 SGTC_2241 6772625 37.8075 µM 0.484966359231664 0.295143941441368 no 1002 0.313850104422016 1454 2285411 SGTC_1129 3453-1384 223 µM 0.483777191162842 0.295549484192141 no 1003 0.31427200203156 1577 1084452 SGTC_1028 k015-0029 4.8 µM 0.481994941586533 0.296157765189005 no 1004 0.314904769838409 1489 4588309 SGTC_3034 9090421 49.47 µM 0.478878652827529 0.297222731022864 no 1005 0.316012479140299 1521 17173761 SGTC_2807 7945238 51.95 µM 0.478192230392961 0.29745754522107 no 1006 0.316256695999858 1555 17148797 SGTC_3282 9108498 15.4605 µM 0.476963125943175 0.297878213819543 no 1007 0.316694189694059 1487 16459645 SGTC_2960 9079389 5.97 µM 0.476872993862433 0.297909072754268 no 1008 0.316726281868288 1625 16457355 SGTC_665 3914-0008 307 µM 0.476825354404904 0.297925383883046 no 1009 0.316743244796285 1464 1069549 SGTC_929 2805-0021 398 µM 0.475869420008603 0.298252769364737 no 1010 0.317083704681858 1562 3098024 SGTC_791 1348-1292 225 µM 0.472855291282013 0.299286109894846 no 1011 0.318158211905693 1575 5437054 SGTC_2160 5660466 132.927 µM 0.471420043358268 0.299778729313126 no 1012 0.318670402747799 1571 2859134 SGTC_2951 9072950 58.06 µM 0.471079816921003 0.299895558875606 no 1013 0.318791868773839 1515 16488155 SGTC_334 1502-1024 68.5 µM 0.470731662916755 0.300015131997222 no 1014 0.318916185217235 1533 3296216 SGTC_2110 5483698 200 µM 0.470532368888415 0.300083589025264 no 1015 0.318987356932495 1525 2848765 YHR062C RPP1 SGTC_1341 1486-1360 280 µM 0.469848124016849 0.300318679277407 no 1016 0.319231764666238 1493 3976547 SGTC_843 0310-0051 143 µM 0.469188641386415 0.300545340551683 no 1017 0.319467401865556 1547 2065037 SGTC_2860 9025725 38.96 µM 0.468778108852532 0.300686477774608 no 1018 0.319614124496236 1479 40546248 SGTC_1067 clotrimazole 1.36 µM 0.466100270437686 0.301607826411197 no 1019 0.320571864859539 1525 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.465404932231792 0.301847274993028 no 1020 0.320820751382767 1559 688801 SGTC_2278 7948257 134.34 µM 0.465008291496358 0.30198390154444 no 1021 0.320962759438747 1636 1247028 SGTC_38 0929-0051 58.268 µM 0.461980952024015 0.303027610235803 no 1022 0.322047490087993 1656 1379719 SGTC_2 0422-0095 29 µM 0.460689392720511 0.303473380203514 no 1023 0.322510733142112 1479 6790840 SGTC_2349 9023730 187.07 µM 0.458637909775389 0.304182032355115 no 1024 0.323247104232697 1621 4126287 SGTC_2745 rifampicin 24.3 µM 0.453638883318309 0.305911945258073 no 1025 0.325044381173298 1658 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3201 9113999 49.47 µM 0.452773253430935 0.306211938218512 no 1026 0.325356012550881 1627 16649224 SGTC_2093 5331342 194.4 µM 0.452759448907646 0.306216723371825 no 1027 0.325360983243028 1615 33839 SGTC_1927 st060202 13.8 µM 0.452514846957978 0.306301516847061 no 1028 0.325449063945259 1627 688887 SGTC_2340 7987427 183.45 µM 0.450579102191958 0.306972925911701 no 1029 0.326146465546873 1584 2239331 SGTC_3030 9087619 49.47 µM 0.450066241344833 0.307150919290059 no 1030 0.326331338853033 1518 25236973 SGTC_3010 9080089 71.4286 µM 0.448760833339492 0.307604178914323 no 1031 0.326802097749109 1635 17027233 SGTC_3260 9137109 49.47 µM 0.447853246183441 0.307919481678331 no 1032 0.32712955628519 1619 17478346 SGTC_641 4092-0595 30 µM 0.446806249100375 0.308283392748456 no 1033 0.327507479448606 1593 786260 SGTC_1825 st052143 62.6 µM 0.446410393282085 0.308421031862229 no 1034 0.327650413309927 1614 674173 SGTC_1828 st055811 49 µM 0.446105650571871 0.308527009285962 no 1035 0.327760465664162 1638 5877589 SGTC_2038 4100038 30.985 µM 0.445642141143483 0.308688230059706 no 1036 0.32792788244896 1591 3596803 SGTC_2878 9043973 25.97 µM 0.445520050074748 0.30873070268364 no 1037 0.327971986755922 1639 6465167 SGTC_2915 7971052 15.16 µM 0.445405352882952 0.308770605481759 no 1038 0.3280134222765 1476 5741558 SGTC_288 1315-0019 35.1 µM 0.444955606437809 0.308927092657471 no 1039 0.328175918148607 1560 6811474 SGTC_691 1548-0686 185 µM 0.444835881103762 0.30896875637585 no 1040 0.32821918105451 1510 46495133 SGTC_2262 9014885 67.46 µM 0.44456502414024 0.309063022089695 no 1041 0.328317064074267 1606 6457424 SGTC_1644 st010134 20.9 µM 0.444400798043243 0.309120183436876 no 1042 0.328376418284368 1579 3818134 SGTC_712 r015-0009 80.6 µM 0.443565640354096 0.309410944038381 no 1043 0.328678326017207 1629 6813872 YLR060W FRS1 SGTC_1827 berberine 7.24 µM 0.44297975635094 0.30961499112461 no 1044 0.328890188613935 1440 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1016 4226-1401 38 µM 0.441835721072709 0.310013595919766 no 1045 0.329304043803251 1538 2901613 SGTC_3291 9121177 71.43 µM 0.441764241789404 0.310038508152736 no 1046 0.329329908410497 1531 17015612 SGTC_297 0986-0032 24 µM 0.438307870298786 0.311244174804309 no 1047 0.330581560733414 1550 2847425 SGTC_2899 9053889 58.44 µM 0.438228081471644 0.311272031086946 no 1048 0.330610477036051 1608 6470052 SGTC_1834 st055981 52.8 µM 0.438020236939258 0.311344599905545 no 1049 0.33068580680809 1658 471719 YDL150W RPC53 SGTC_3348 9149464 3.537 µM 0.437754698191089 0.311437323298561 no 1050 0.330782056860864 1552 1951442 SGTC_918 glabranin 770.725 nM 0.437729879441141 0.311445990361503 no 1051 0.330791053505818 1623 124049 Also referred to as licorice root. SGTC_1919 st067113 52.3 µM 0.436608335786656 0.311837758463552 no 1052 0.331197708151313 1553 1268243 SGTC_2820 7989630 71.43 µM 0.436045827351075 0.312034329368921 no 1053 0.331401740167908 1627 2984098 SGTC_1066 ketoconazole 628 nM 0.433617736912765 0.312883449405779 no 1054 0.33228302627667 1645 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2126 5251174 33.877 µM 0.427319706935875 0.315090537145282 no 1055 0.334573240458719 1768 790722 SGTC_2238 6671620 73.2395 µM 0.427089109867512 0.315171473860504 no 1056 0.334657212303071 1496 729941 SGTC_2412 st077135 33.4 µM 0.425674934853627 0.315668025724938 no 1057 0.335172364402168 1672 13258915 SGTC_1749 st037932 54.2 µM 0.425589694260843 0.315697966455284 no 1058 0.335203425550687 1570 594497 SGTC_1895 st058434 18.3 µM 0.424266397774916 0.316162928958577 no 1059 0.335685771081003 1705 5393175 SGTC_1877 wortmannin 25 µM 0.423718268921354 0.316355608500161 no 1060 0.335885645067549 1669 312145 A covalent inhibitor of PI 3-kinase. SGTC_3318 9139014 38.6185 µM 0.423559077169017 0.316411577305276 no 1061 0.335943702693514 1594 16643984 SGTC_3187 9109394 49.47 µM 0.420265516872513 0.317570472660589 no 1062 0.337145748854361 1539 17098090 SGTC_2659 sanguinarine 24.21 µM 0.419163261872002 0.317958720240471 no 1063 0.337548409727424 1593 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3094 9117742 49.47 µM 0.418956746537777 0.318031483470824 no 1064 0.337623871823326 1535 17149698 SGTC_796 1234-0020 70.7 µM 0.418295182433042 0.318264625027384 no 1065 0.337865655756613 1554 46495034 SGTC_1812 st052057 4.327 µM 0.417798314155308 0.318439773546849 no 1066 0.338047291790806 1555 3645418 SGTC_959 1222-0044 107 µM 0.416623758818994 0.318853971416899 no 1067 0.338476814155962 1723 6083612 SGTC_2071 5230951 39.92 µM 0.416458097602925 0.318912408791425 no 1068 0.338537411625131 1616 1799272 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.416299323426248 0.318968420972167 no 1069 0.338595493797383 1607 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2489 cantharidin 73.42 µM 0.416069826564804 0.319049389931092 no 1070 0.338679454261143 1555 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_697 0508-1955 564 µM 0.415948847197413 0.319092076227777 no 1071 0.338723717282483 1710 6243113 SGTC_2030 5175110 200 µM 0.415529233410832 0.319240151124276 no 1072 0.338877259677569 1660 2831986 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.414501598104293 0.319602908711771 no 1073 0.339253398451767 1570 688664 SGTC_2235 salicylic acid 500 µM 0.413675856272408 0.319894522586986 no 1074 0.339555755584896 1637 338 A COX inhibitor and kinase inhibitor. SGTC_15 0266-0086 27.098 µM 0.413273831290408 0.320036539552617 no 1075 0.339703000158308 1667 1712902 YIL048W NEO1 SGTC_2229 7354935 190 µM 0.411621251772023 0.320620596869481 no 1076 0.340308526203076 1645 318112 SGTC_3107 9121808 49.47 µM 0.409225558876597 0.32146807537158 no 1077 0.341187069647425 1655 662681 SGTC_2829 7992743 58.44 µM 0.40877242770559 0.321628475665728 no 1078 0.341353337991825 1798 16462845 SGTC_1526 st051518 75 µM 0.4082001390054 0.321831103107339 no 1079 0.341563373062134 1601 673993 SGTC_2955 9076254 12.21 µM 0.406793241321149 0.322329461628499 no 1080 0.342079925576634 1721 16459619 SGTC_3344 9148862 3.898 µM 0.405579589725901 0.322759624273027 no 1081 0.342525764021347 1694 4905352 SGTC_1909 st060837 51.5 µM 0.404127535054731 0.323274597468879 no 1082 0.343059468906597 1590 678937 SGTC_2927 9011802 47.9 µM 0.402356894099065 0.323903016167229 no 1083 0.34371069448804 1538 43912568 SGTC_1540 guanosine 70.6 µM 0.401698356603222 0.324136866138409 no 1084 0.343953017066341 1689 6802 Guanosine is a purine nucleoside SGTC_70 0141-0289 43.283 µM 0.401426969138099 0.324233257389326 no 1085 0.344052898392062 1705 352408 SGTC_518 1021-0119 62.6 µM 0.399529708359841 0.324907454218887 no 1086 0.34475146904299 1566 1097762 SGTC_836 0330-0104 1.35 µM 0.398170977009763 0.325390635943025 no 1087 0.345252079023917 1662 46494820 SGTC_622 1348-1566 26.3 µM 0.397597546551073 0.325594643090636 no 1088 0.345463434657917 1713 7340407 SGTC_2390 9097792 176.6 µM 0.396972018371188 0.325817244433416 no 1089 0.345694047485792 1563 4497149 SGTC_3254 9136651 49.47 µM 0.395922849686421 0.3261907425079 no 1090 0.346080971970851 1604 16454030 SGTC_1227 3909-8010 46.6 µM 0.395858384612305 0.326213697397891 no 1091 0.346104751387667 1643 15982272 SGTC_3277 9138724 49.47 µM 0.392912140155132 0.327263505218271 no 1092 0.347192187339878 1650 15943418 SGTC_3246 9135460 32.98 µM 0.392353711716795 0.327462639268444 no 1093 0.347398441176521 1689 41446951 SGTC_1516 st013856 110 µM 0.391837134024095 0.327646893178927 no 1094 0.347589277811117 1627 5281404 A mutagen and neurotoxin. SGTC_2819 7996655 46.38 µM 0.390156252475977 0.328246723530141 no 1095 0.348210504358371 1714 6456960 SGTC_553 k007-0256 45.7 µM 0.389531221067686 0.32846988197706 no 1096 0.348441609851198 1669 6287000 SGTC_638 3970-0837 4.09 µM 0.388573328111479 0.328812002591938 no 1097 0.348795900151054 1606 4118451 YLR208W SEC13 SGTC_2060 5238662 140 µM 0.38790142530564 0.329052064744391 no 1098 0.349044491658352 1630 790130 SGTC_1670 st016595 4.04 µM 0.386275190678286 0.32963338901579 no 1099 0.349646436171966 1659 597879 SGTC_2460 5552655 174.22 µM 0.384285298156146 0.330345269044762 no 1100 0.350383501700094 1599 5401989 SGTC_987 1497-1013 404 µM 0.383026379991958 0.330795961993067 no 1101 0.350850102251033 1674 1676435 SGTC_819 1013-0258 27.7 µM 0.381934472261565 0.331187063925122 no 1102 0.351254984970237 1635 5753198 SGTC_725 1497-0963 19 µM 0.380018237148274 0.331873870433016 no 1103 0.351965938810962 1795 3549977 SGTC_3055 9094636 49.47 µM 0.379697161730763 0.331989003891399 no 1104 0.352085113640204 1707 25236176 SGTC_1916 st067606 49.2 µM 0.379668868587879 0.331999150204303 no 1105 0.352095616014396 1758 19590279 SGTC_1162 k048-0130 20.1 µM 0.37918902590027 0.332171247194127 no 1106 0.352273750109796 1652 6797406 SGTC_2983 9022671 12.99 µM 0.377533036834743 0.332765444250867 no 1107 0.352888758903151 1815 6405161 SGTC_2898 9056270 58.44 µM 0.376587773021333 0.333104809528649 no 1108 0.353239987827341 1676 19154699 SGTC_3269 9137823 49.47 µM 0.374938574407136 0.333697226209333 no 1109 0.353853075009936 1635 17682936 SGTC_780 0109-0199 192 µM 0.374768196049165 0.333758452317978 no 1110 0.353916434552932 1795 610414 SGTC_3017 9080681 49.47 µM 0.374735397948141 0.333770238948023 no 1111 0.353928631828713 1641 16451914 SGTC_3231 9132313 49.47 µM 0.374219624832311 0.333955613528317 no 1112 0.354120462243379 1689 4905967 SGTC_1805 st050013 60.3 µM 0.37393391602825 0.334058317886926 no 1113 0.354226741260549 1711 4037144 SGTC_2284 7945075 39.21 µM 0.370142858841432 0.335422271363699 no 1114 0.355638024784924 1816 1245402 SGTC_1954 st077032 68.9 µM 0.369894265366069 0.335511786852391 no 1115 0.355730637230087 1592 698907 SGTC_2024 5144227 134 µM 0.369042674192333 0.33581850523703 no 1116 0.356047958437753 1742 3475211 SGTC_1064 honokiol 6.76 µM 0.367299534838794 0.336446674311949 no 1117 0.356697800510894 1684 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3257 9139206 32.98 µM 0.366361654388963 0.3367848441526 no 1118 0.357047614509679 1740 4910041 SGTC_3166 9102297 49.47 µM 0.36341822651515 0.337847006719922 no 1119 0.358146244197835 1635 25237072 SGTC_213 1246-0773 967 nM 0.362856252094865 0.338049947478874 no 1120 0.358356134172119 1710 6251622 SGTC_1789 tunicamycin 25 nM 0.361926836447571 0.338385682259671 no 1121 0.35870335246639 1770 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1990 st072050 59.8 µM 0.361518899627534 0.338533082740282 no 1122 0.358855789566657 1643 17233948 SGTC_296 1222-0039 74.9 µM 0.360779702162799 0.338800241192419 no 1123 0.359132068816444 1633 5984176 SGTC_2299 7976368 114.88 µM 0.360574288037837 0.338874495735339 no 1124 0.359208856601678 1792 2979718 SGTC_3093 9117344 49.47 µM 0.36021224595625 0.339005384495547 no 1125 0.359344208800468 1699 24824913 SGTC_1519 esterone 74 µM 0.359699746709987 0.339190701132464 no 1126 0.359535840737559 1599 698 A steroid. SGTC_80 0159-0065 512.242 µM 0.358780950653946 0.339523029625891 no 1127 0.359879482181752 1778 1548079 SGTC_2397 5161689 200 µM 0.358645629096306 0.339571985979285 no 1128 0.359930103748641 1748 2259942 SGTC_3293 9120939 62.045 µM 0.358444029625043 0.339644925239592 no 1129 0.360005523348136 1740 934087 SGTC_1746 st038117 42 µM 0.356789949060357 0.34024360284814 no 1130 0.36062453060444 1687 2898218 SGTC_779 1360-0071 233 µM 0.356125247698877 0.34048429831468 no 1131 0.360873385082538 1850 7566 SGTC_1575 cyproterone acetate 48 µM 0.355933871534805 0.340553609721896 no 1132 0.360945044449536 1621 9880 An androgen receptor antagonist and liver toxin. SGTC_1792 st045773 43.6 µM 0.355214657148183 0.340814138364522 no 1133 0.361214392498564 1690 2919270 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.355105258385809 0.340853773694026 no 1134 0.361255368712303 1732 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_457 grayanotoxin iii 135 µM 0.354857937532324 0.340943384870898 no 1135 0.36134801065581 1703 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2828 7998861 71.43 µM 0.354808642046158 0.340961247060001 no 1136 0.361366476830313 1822 2988188 SGTC_778 3456-2434 196 µM 0.354411399490182 0.341105200664391 no 1137 0.361515296364807 1844 5539063 SGTC_2048 5246248 200 µM 0.354088997608027 0.341222050351923 no 1138 0.361636093637716 1801 677046 SGTC_2798 7813637 45.45 µM 0.351322796320162 0.342225242952906 no 1139 0.362673097304851 1749 956368 SGTC_3126 9127922 49.47 µM 0.350076707123208 0.342677515122056 no 1140 0.363140565603266 1735 45595682 SGTC_1282 0886-0010 32.4 µM 0.349454415578791 0.342903462391985 no 1141 0.363374093649567 1836 2836211 YNL267W PIK1 SGTC_505 gw-5074 63.9 µM 0.348045690393674 0.343415162634324 no 1142 0.363902935033103 1782 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1033 k072-0102 21.3 µM 0.347452290337227 0.343630793132511 no 1143 0.364125777607271 1812 5965931 SGTC_564 3555-0129 330 µM 0.347025717559287 0.343785833158743 no 1144 0.364285999068282 1778 563260 SGTC_443 clozapine 122 µM 0.34686289633929 0.343845018281936 no 1145 0.364347161251594 1810 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1048 3161-0300 24.5 µM 0.343574459096986 0.345041174731471 no 1146 0.365583167669847 1663 2165101 SGTC_2890 9046729 58.44 µM 0.343244238232278 0.345161377144523 no 1147 0.365707363325469 1649 903329 SGTC_997 3996-0078 137 µM 0.342488161842973 0.345436652391548 no 1148 0.365991775710623 1707 735687 SGTC_2570 licareol 100 µM 0.342261577068755 0.345519164193024 no 1149 0.366077024195499 1670 443158 SGTC_2981 9013952 38.96 µM 0.341529212787705 0.345785907925916 no 1150 0.366352608409381 1599 2996344 SGTC_2970 9090938 41.86 µM 0.341499980848414 0.345796556453182 no 1151 0.366363609641525 1874 17217104 SGTC_3271 9137798 49.47 µM 0.341219132582101 0.345898869271419 no 1152 0.366469310481156 1824 6498326 SGTC_1179 1021-1431 9.29 µM 0.34121859207306 0.34589906618932 no 1153 0.36646951391842 1737 2840958 SGTC_656 4090-1979 187 µM 0.341172634886966 0.345915809433737 no 1154 0.36648681146144 1844 22330961 SGTC_1657 st012939 43.4 µM 0.340080898628002 0.346313642223107 no 1155 0.366897803043145 1807 24207257 SGTC_416 estradiol valerate 100 µM 0.339572952290039 0.346498797622804 no 1156 0.367089074966053 1741 13791 A steroid. SGTC_1884 5633444 25 µM 0.339483087781144 0.346531558641482 no 1157 0.367122917719822 1754 5724239 SGTC_115 0527-0192 112.043 µM 0.339281683699055 0.346604986712562 no 1158 0.367198769753105 1716 4233931 SGTC_1239 0337-0584 35.4 µM 0.338810725673914 0.346776711480922 no 1159 0.367376160385875 1852 914301 YML130C ERO1 SGTC_1534 6-azauridine 81.6 µM 0.336682683093039 0.347553048759 no 1160 0.368178059447433 1732 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1824 st053723 68.6 µM 0.336519734934542 0.347612520753477 no 1161 0.368239486073045 1665 675225 SGTC_3194 9111903 49.47 µM 0.335564492852318 0.347961235574253 no 1162 0.368599651728449 1772 17087251 SGTC_2646 retinol 96.75 µM 0.3352208872795 0.348086701589239 no 1163 0.368729233450841 1731 445354 A vitamin A analog and teratogen. SGTC_1098 clofazimine 15.1 µM 0.334218978983879 0.34845263875863 no 1164 0.369107161740966 1801 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3144 9087057 49.47 µM 0.333743133400138 0.348626486125733 no 1165 0.369286699076402 1899 17249618 SGTC_2200 6600604 21.907 µM 0.333471778557405 0.348725638248559 no 1166 0.369389094481949 1718 2904777 SGTC_2124 5246320 200 µM 0.332513045739779 0.34907603862044 no 1167 0.369750945252341 1747 579342 SGTC_1023 4482-3888 16 µM 0.328801531040202 0.35043374480987 no 1168 0.371152852883071 1840 3303168 SGTC_500 h-89 112 µM 0.326514135178694 0.351271449335652 no 1169 0.372017698242293 1870 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_745 0469-0705 296 µM 0.323051093925354 0.352541081189098 no 1170 0.373328273703872 1864 3486736 SGTC_141 0443-0274 32.331 µM 0.321600367085034 0.35307344116007 no 1171 0.373877732852871 1885 1627241 SGTC_1166 k206-0078 225 µM 0.321052565550939 0.353274537771036 no 1172 0.37408527805632 1710 5404595 SGTC_2557 derrustone 83.84 µM 0.320542549642583 0.353461800205412 no 1173 0.374278540260677 1682 629853 An antioxidant. SGTC_1219 1469-0211 33.1 µM 0.320336170581891 0.353537586446787 no 1174 0.374356753219821 1853 6822282 SGTC_2814 7977482 42.97 µM 0.319860140703578 0.353712415637185 no 1175 0.374537177405487 1852 6456762 SGTC_3002 9075603 71.4286 µM 0.319723918952126 0.353762450821086 no 1176 0.374588813042721 1766 20105405 SGTC_676 falcarinol 140 µM 0.319712612726119 0.353766603789017 no 1177 0.374593098833711 1870 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_52 0329-0193 875 nM 0.318503006844337 0.354211012908492 no 1178 0.375051707094309 1840 3739292 SGTC_1254 0550-0035 264 µM 0.316982731972572 0.354769843443817 no 1179 0.375628352511225 1835 15121435 SGTC_154 3389-1638 511.116 µM 0.314958725365843 0.355514323389258 no 1180 0.376396496235831 1634 5238686 SGTC_401 neomycin 50 µM 0.314054042822348 0.35584726667225 no 1181 0.376739996680004 1790 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1936 st074407 74.3 µM 0.313727916575871 0.355967315362322 no 1182 0.376863848054602 1692 809813 SGTC_2851 9015922 71.43 µM 0.313332440786376 0.356112911123116 no 1183 0.377014052967051 1841 2996893 SGTC_920 mycophenolic acid 780.421 nM 0.312552711579638 0.356400032540694 no 1184 0.37731025495239 1720 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_359 0081-0058 15.9 µM 0.310656609381923 0.357098577900345 no 1185 0.378030843411439 1892 3494159 SGTC_2443 5493264 126.67 µM 0.309304875558484 0.357596864628803 no 1186 0.378544811268548 1864 5340055 SGTC_728 3030-5151 22.5 µM 0.30921167839 0.357631228658072 no 1187 0.37858025542732 1789 3125388 SGTC_462 ag-879 158 µM 0.308422525198237 0.357922254587347 no 1188 0.378880422102268 1867 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3162 9099653 49.47 µM 0.308180783322223 0.358011421307548 no 1189 0.378972387007412 1850 25237511 SGTC_717 1532-0246 73.2 µM 0.308157711095088 0.358019931925427 no 1190 0.378981164641717 1757 9561992 SGTC_1634 st006576 41 µM 0.307850198169359 0.358133370493894 no 1191 0.379098161299268 1910 3915356 SGTC_974 1326-0144 138 µM 0.307601087766602 0.35822527411537 no 1192 0.379192946199047 1740 5411856 SGTC_3116 9124943 49.47 µM 0.307270929713701 0.358347091083043 no 1193 0.379318580397913 1668 41905195 YPL160W CDC60 SGTC_493 zm226600 134 µM 0.306449704587501 0.358650157424206 no 1194 0.379631134348398 1804 5240098 A potassium channel opener. YCR052W RSC6 SGTC_264 promethazine 12.5 mM 0.305010688011603 0.359181429178589 no 1195 0.380179006049781 1890 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1596 piperlongumine 63 µM 0.304765579309868 0.359271948249206 no 1196 0.380272349422187 1888 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2835 9006588 71.43 µM 0.303662264451471 0.359679502092079 no 1197 0.380692604897346 1729 2345538 SGTC_414 piperonyl butoxide 100 µM 0.302195899466471 0.360221410148235 no 1198 0.381251364979066 1734 5794 A potent inhibitor of cytochrome P450. SGTC_3195 9113082 49.47 µM 0.301236513191658 0.360576111895165 no 1199 0.381617074324705 1926 17018038 SGTC_1734 st037168 69.4 µM 0.299937360664316 0.361056622345612 no 1200 0.382112467914898 1733 708907 SGTC_467 ro 31-8220 72.8 µM 0.29980397368265 0.361105969889263 no 1201 0.382163342057858 1893 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2977 9011197 71.43 µM 0.299512863570651 0.361213676349577 no 1202 0.382274379278589 1838 2704722 SGTC_1501 4491-0275 38.4 µM 0.298060057959253 0.361751357380289 no 1203 0.382828662941402 1890 5104718 SGTC_351 caspofungin 25 nM 0.297014615368651 0.362138443017594 no 1204 0.383227675462799 1831 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3103 9120822 49.47 µM 0.296625064597278 0.362282714198041 no 1205 0.383376386438126 1896 17141819 SGTC_395 anisomycin 6.25 µM 0.29646194139752 0.362343133128266 no 1206 0.383438663812225 1782 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_226 1,3-diallylurea 8.28947 mM 0.295454425411085 0.362716381241765 no 1207 0.383823381184288 1820 74537 YKL182W FAS1 SGTC_2524 avocatin b 10.57 µM 0.294480086058763 0.36307746273718 no 1208 0.384195539090649 1885 6710748 SGTC_85 0868-0259 160.055 µM 0.294460018448594 0.363084900895553 no 1209 0.38420320522308 1806 83173 SGTC_134 0269-0018 6.916 µM 0.293035496362942 0.36361303880397 no 1210 0.384747509909288 1746 4378915 SGTC_3168 9103419 49.47 µM 0.29292417625724 0.363654321383138 no 1211 0.38479005450175 1883 16649256 SGTC_975 1335-0046 28.5 µM 0.292313393544943 0.363880855667373 no 1212 0.385023509619986 1699 16486740 SGTC_3259 9138485 49.47 µM 0.292194818925235 0.363924839536488 no 1213 0.385068836385106 1893 17646153 SGTC_1388 3346-4487 254 µM 0.291688682339177 0.364112605139994 no 1214 0.385262331647794 1848 3345614 SGTC_1479 0549-0158 134 µM 0.291270540792647 0.364267751120522 no 1215 0.385422208090115 1781 5440202 SGTC_446 go6976 132 µM 0.290458685505155 0.364569042962569 no 1216 0.385732676587016 1918 3501 A protein kinase C inhibitor. SGTC_1817 st052116 64.4 µM 0.288842001645271 0.365169268000874 no 1217 0.386351144329752 1871 4361398 SGTC_1128 3448-9350 235 µM 0.287938588825369 0.365504821448644 no 1218 0.386696873792026 1755 619386 SGTC_1088 bifonazole 369 nM 0.286777049320021 0.365936401821239 no 1219 0.387141518574209 1813 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1372 2752-0194 270 µM 0.286404753470375 0.366074767606993 no 1220 0.387284067192435 1778 823334 SGTC_1013 4112-3890 241 µM 0.286224256725988 0.366141856478295 no 1221 0.387353183189405 1770 705171 SGTC_2178 5812956 200 µM 0.285222126742781 0.366514412755772 no 1222 0.387736984713339 1815 5403383 SGTC_910 3454-3003 490 µM 0.284900040222267 0.366634179800487 no 1223 0.387860362583212 1918 820824 SGTC_205 1486-1330 71.903 µM 0.284416677741487 0.366813941262276 no 1224 0.388045539767043 1834 4118834 SGTC_1736 st036774 51 µM 0.281991559909305 0.367716277560134 no 1225 0.388974991007273 1998 1272247 SGTC_3024 9090631 49.47 µM 0.281788109133398 0.367792010683104 no 1226 0.389052994578764 1954 25236383 SGTC_2082 5219693 150 µM 0.28151960114488 0.36789196876508 no 1227 0.3891559481048 1766 2834649 SGTC_1703 st026983 48.3 µM 0.279597828387125 0.368607652308131 no 1228 0.389893036687929 1935 1104023 SGTC_1305 1181-0477 144 µM 0.276627275120591 0.369714806552062 no 1229 0.391033159575067 1932 6252086 SGTC_1054 3429-0080 167 µM 0.276123214534156 0.3699027823866 no 1230 0.391226715461795 1887 1162877 SGTC_1671 st016596 74.5 µM 0.274746756304464 0.370416253689208 no 1231 0.391755403298569 1819 2829167 SGTC_1875 nocodazole 6 µM 0.274456402829389 0.370524596114256 no 1232 0.391866951579512 1959 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_561 1550-0330 72.9 µM 0.27396284663155 0.370708785115549 no 1233 0.392056586874353 1788 6812934 SGTC_998 3996-0085 177 µM 0.272908822073343 0.371102233074686 no 1234 0.392461652411871 1923 715391 SGTC_3179 9107801 49.47 µM 0.272348763532526 0.371311347473051 no 1235 0.392676932419273 1780 4818259 SGTC_362 0310-0100 9.03 µM 0.270984755169526 0.371820799123467 no 1236 0.393201378672687 1808 790235 SGTC_1650 st011916 45.8 µM 0.270782116265607 0.37189650311834 no 1237 0.393279307671773 1946 242528 SGTC_2411 st077133 39.94 µM 0.26604688809454 0.373666944425887 no 1238 0.395101549179622 1979 1403142 YNL221C POP1 SGTC_2532 xanthone 78.9 µM 0.265975794057614 0.373693546009271 no 1239 0.395128925650415 1902 7020 An insecticide. SGTC_33 0986-0033 35.816 µM 0.265352585026323 0.373926760748418 no 1240 0.395368929438572 1892 2848082 SGTC_1980 st071811 45.7 µM 0.265059628784195 0.374036405591643 no 1241 0.395481763423385 1905 4974850 SGTC_3137 9097352 49.47 µM 0.264499317857246 0.374246141754706 no 1242 0.395697595185743 1918 44120435 SGTC_477 mead ethanolamide 10 µM 0.263877670803616 0.374478880878226 no 1243 0.395937091054042 1869 16061185 SGTC_2686 alizarin 95.37 µM 0.263575293263652 0.374592104878779 no 1244 0.396053599294439 1784 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1243 0416-0003 5.65 µM 0.26347446080692 0.374629863573588 no 1245 0.39609245283012 1816 2141977 SGTC_2884 9058502 51.95 µM 0.263236308282251 0.374719049238185 no 1246 0.396184223685131 1806 6471554 SGTC_1556 plumbagin 1.48 µM 0.262883424531876 0.374851212884219 no 1247 0.396320216207134 1925 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1409 3909-8004 61.9 µM 0.262820358340105 0.374874834273238 no 1248 0.396344521660562 1850 2119279 SGTC_3342 9147791 14.508 µM 0.259779231537652 0.376014441288712 no 1249 0.397517035965667 1871 1838168 SGTC_2236 dapsone 200 µM 0.259373479333803 0.376166571588532 no 1250 0.39767354506581 1969 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2825 7998094 58.44 µM 0.259368588464688 0.376168405459112 no 1251 0.397675431700814 1849 2987815 SGTC_1020 4335-0961 93.3 µM 0.259049165370674 0.376288181761167 no 1252 0.397798653179936 1758 669075 SGTC_165 k038-0023 64.381 µM 0.257778054695785 0.376764936927158 no 1253 0.398289101029047 1814 46368543 SGTC_1367 1812-0510 76.9 µM 0.257706240142722 0.376791878011164 no 1254 0.398316814901648 1884 1142582 YDR527W RBA50 SGTC_3170 9103054 49.47 µM 0.257356606810494 0.376923050816032 no 1255 0.398451748828532 1839 16432970 SGTC_2948 9070189 9.45 µM 0.256642588646714 0.377190974900446 no 1256 0.398727347426471 1975 6473636 YDL196W YDL196W SGTC_3297 9117502 71.43 µM 0.256493977162272 0.377246746460819 no 1257 0.398784715230332 1921 7453720 SGTC_485 niflumic acid 177 µM 0.254226497351135 0.378098013024396 no 1258 0.399660290498373 1906 4488 A COX2 inhibitor. SGTC_594 1487-1584 10.8 µM 0.253941014455426 0.378205232238454 no 1259 0.399770564071145 1782 5013332 SGTC_3155 9099265 49.47 µM 0.251719615858748 0.379039845911138 no 1260 0.400628896924475 1905 25236499 SGTC_478 N-arachidonylglycine 10 µM 0.248288310513885 0.3803301479165 no 1261 0.40195567137557 1964 5283389 SGTC_767 0929-0023 86 µM 0.247185211864104 0.38074523897545 no 1262 0.402382444744639 1854 1204563 SGTC_2291 7917025 104.35 µM 0.246680080897103 0.380935363349251 no 1263 0.40257791169771 1803 2964612 SGTC_1056 3448-1962 115 µM 0.245327707992904 0.381444519385849 no 1264 0.403101349636348 1893 715507 SGTC_3007 9078383 71.4286 µM 0.244504553622448 0.38175453002258 no 1265 0.403420037850013 1855 6496995 SGTC_937 3122-0005 46.7 µM 0.244097215325595 0.381907966988765 no 1266 0.403577764588996 1988 759535 SGTC_1635 st007035 42.4 µM 0.2436568676481 0.382073858859805 no 1267 0.403748290634485 1877 3716403 SGTC_49 0717-0965 32.132 µM 0.243570510244813 0.382106394764161 no 1268 0.403781734961911 1960 5889349 YGL099W LSG1 SGTC_1029 k015-0030 64.7 µM 0.243162068567766 0.38226029000322 no 1269 0.403939924989325 1911 2208316 SGTC_1932 st074806 40.9 µM 0.243024772320864 0.382312025530191 no 1270 0.403993103545619 1932 17251235 SGTC_596 1155-0152 116 µM 0.240912472328911 0.383108239858162 no 1271 0.404811477640741 1837 280313 SGTC_2540 epiandrosterone 100 µM 0.240506509856651 0.383261320823279 no 1272 0.404968808607221 1986 441302 A steroid. SGTC_1841 st054148 70 µM 0.240075903740564 0.383423714374866 no 1273 0.405135707019223 1838 675442 SGTC_746 1095-0025 46.6 µM 0.239988699718571 0.383456603933716 no 1274 0.405169508484981 1939 6749286 SGTC_2749 bexarotene 57.39 µM 0.237738235220246 0.384305670985861 no 1275 0.406042063151681 1820 82146 An retinoic acid receptor inhibitor. SGTC_888 0916-0002 6.97 µM 0.236064942102988 0.38493734007025 no 1276 0.40669113866647 1951 2802138 YIL048W NEO1 SGTC_1870 st057514 26.5 µM 0.235834089351329 0.385024511131486 no 1277 0.406780707323269 1865 5393161 SGTC_2401 5128683 200 µM 0.234664007785157 0.385466428599165 no 1278 0.407234762668098 1817 708373 SGTC_684 1140-0066 328 µM 0.234432667098618 0.385553819188716 no 1279 0.407324550230367 1868 6813534 SGTC_923 1900-2434 73.3 µM 0.233051819498821 0.38607556489315 no 1280 0.407860583626793 1833 5910570 SGTC_2123 5259487 200 µM 0.231956248274089 0.386489667171391 no 1281 0.40828599793174 1971 2173474 SGTC_2207 7258803 200 µM 0.23076858669448 0.386938723671628 no 1282 0.408747293378817 1972 3666799 SGTC_2598 perillyl alcohol 100 µM 0.230325201551228 0.387106407053008 no 1283 0.408919539486726 1947 10819 An apoptosis inducer. SGTC_529 4076-0302 30.3 µM 0.229440675854599 0.387440987852835 no 1284 0.409263212244301 1871 5816522 SGTC_2941 9056145 11.23 µM 0.229405523756425 0.387454286219057 no 1285 0.409276871649308 2025 2119517 SGTC_955 1216-0110 33 µM 0.2289056945666 0.38764339053936 no 1286 0.409471107224991 1849 3619719 SGTC_3332 9141069 11.198 µM 0.228264162889452 0.387886145337281 no 1287 0.409720441503066 1824 17332883 SGTC_2664 lyso-paf C-16 73.48 µM 0.226588997152496 0.388520232385474 no 1288 0.410371674391698 1925 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1198 1612-1005 86.7 µM 0.226489710213693 0.388557824019513 no 1289 0.41041028069097 1988 6998509 SGTC_1192 1488-0095 21.4 µM 0.22613009734708 0.388693987976326 no 1290 0.410550118250197 1919 915875 SGTC_1053 3366-3204 134 µM 0.224955918682086 0.389138674594367 no 1291 0.411006783561263 1832 3632071 YPR165W RHO1 SGTC_81 0411-0046 9.971 µM 0.224161552976849 0.389439600316453 no 1292 0.411315799256749 1943 12925265 SGTC_1415 3966-0071 78.1 µM 0.223695713771553 0.3896161027886 no 1293 0.41149704067832 1944 2893185 SGTC_874 0599-0792 117 µM 0.22201921746014 0.390251501019699 no 1294 0.412149461637331 2050 765305 SGTC_210 3551-0445 56.827 µM 0.221706460512048 0.390370069557543 no 1295 0.412271200255032 1969 2865180 YOR207C RET1 SGTC_839 0122-0028 230 µM 0.220090806277737 0.390982738538254 no 1296 0.412900217399158 1932 759448 SGTC_3236 9132701 49.47 µM 0.21865246799946 0.391528395693374 no 1297 0.413460389007339 1890 24282524 SGTC_41 0478-0632 82.643 µM 0.217620060734202 0.391920187967165 no 1298 0.413862576433682 2078 3750424 SGTC_885 0865-0106 16.8 µM 0.217131730212631 0.392105544641483 no 1299 0.414052843327779 1848 2793380 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.217107504829226 0.392114740560604 no 1300 0.414062282723703 1997 16725076 SGTC_2581 avocatin a 64 µM 0.216277289914561 0.392429925279428 no 1301 0.414385805087562 1913 6710728 A skin care supplement. SGTC_2876 9059903 25.97 µM 0.214215862420671 0.393212835158615 no 1302 0.415189363382382 2028 6916095 SGTC_2154 5570129 200 µM 0.213671420371001 0.393419681147855 no 1303 0.415401649934376 2008 673366 SGTC_1801 st050089 28.441 µM 0.213525337466745 0.393475186506499 no 1304 0.415458614170251 1946 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_314 1671-0008 2.74 µM 0.212714663258274 0.393783247917551 no 1305 0.41577476443786 1953 3913060 SGTC_2888 9058547 12.99 µM 0.208990462246025 0.395199319732913 no 1306 0.417227842122919 1905 16476514 SGTC_2296 7971656 126.45 µM 0.207315761471508 0.395836552318062 no 1307 0.417881632831142 1899 666570 SGTC_2333 9017922 200 µM 0.205565142320491 0.396502969970748 no 1308 0.418565304180924 2032 3163164 SGTC_2101 5377231 179.231 µM 0.204097834876058 0.397061770923514 no 1309 0.419138523122801 2009 2844213 SGTC_2505 galangin 7.89 µM 0.202398759886987 0.397709100966475 no 1310 0.419802498903635 1867 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1845 st056753 3.01 µM 0.201574566867157 0.398023211602993 no 1311 0.420124664885189 1860 5375839 SGTC_1685 st024049 53.0905 µM 0.201439973630354 0.398074513113582 no 1312 0.420177280663645 1986 1941139 SGTC_2308 7584454 197.62 µM 0.201342518689622 0.398111660104288 no 1313 0.420215379066987 2036 893577 SGTC_489 paxilline 115 µM 0.201083610626303 0.398210352817436 no 1314 0.420316598538665 1940 105008 A toxic potassium channel blocker. SGTC_148 3253-0744 288.01 µM 0.200348087556755 0.398490761082254 no 1315 0.42060417820567 2068 6893655 SGTC_257 daunorubicin 18.5 µM 0.199341527058504 0.398874583641319 no 1316 0.420997798531072 2061 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2417 cerulenin 830 nM 0.19911057975218 0.398962662485851 no 1317 0.421088122740804 2082 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1143 3454-2408 5.08 µM 0.198464960008989 0.399208916675325 no 1318 0.421340648651237 1994 X1143 SGTC_1759 st043059 70 µM 0.198106990804864 0.399345471639637 no 1319 0.42148067768125 1887 669426 SGTC_1096 rimcazole 32.2 µM 0.196812582651641 0.399839353823275 no 1320 0.421987102085414 1934 18528119 A dopamine reuptake inhibitor. SGTC_1901 st060216 58.6 µM 0.196519216417155 0.399951310187754 no 1321 0.422101896691889 1910 688792 SGTC_794 k038-0031 316 µM 0.194821418748008 0.400599396224872 no 1322 0.422766376915321 1985 6624242 SGTC_1675 st018485 24.5 µM 0.194553782919663 0.400701583622239 no 1323 0.42287114372707 1928 3323024 SGTC_2325 6158266 200 µM 0.194335347935504 0.400784990431973 no 1324 0.422956654770907 1948 3623240 SGTC_1930 st074634 34.3 µM 0.194060147993163 0.40089007870693 no 1325 0.423064392838111 1871 684253 YOR116C RPO31 SGTC_166 k072-0058 166.424 µM 0.193894823046513 0.400953213395444 no 1326 0.423129118693683 2108 5846229 SGTC_3264 9137442 49.47 µM 0.193053497565332 0.401274540840448 no 1327 0.423458535525555 2065 17015726 SGTC_2063 5246145 200 µM 0.193003184326802 0.401293759094316 no 1328 0.423478237123185 2007 711240 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.189421587269179 0.402662440153913 no 1329 0.424881203267662 1982 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2444 5485484 36.41 µM 0.18290637409518 0.405155231380707 no 1330 0.427435740733048 2032 6790631 SGTC_1871 st057448 67.3 µM 0.182845320853928 0.405178609391585 no 1331 0.427459693550833 2057 691747 SGTC_1618 st003135 44.5 µM 0.181273977880194 0.405780411459254 no 1332 0.428076265140958 2082 1270615 SGTC_1283 0922-0125 16.4 µM 0.178437395494296 0.406867345354951 no 1333 0.429189741582806 2062 3360884 SGTC_2925 9010536 32.5 µM 0.177611952711896 0.407183777285602 no 1334 0.429513868447 2013 2994177 SGTC_1252 0493-0875 34.8 µM 0.177278434259627 0.407311648151348 no 1335 0.429644844729466 1977 3960963 SGTC_2978 9011784 42.97 µM 0.176448414587032 0.407629920277461 no 1336 0.429970835968204 2122 2994934 SGTC_87 0100-0052 35.5 µM 0.175896547042358 0.407841568370574 no 1337 0.430187609059708 2014 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_161 4065-0411 162.148 µM 0.175705937377755 0.407914675809105 no 1338 0.430262485262708 2001 1906281 YLR208W SEC13 SGTC_285 1486-1325 46 µM 0.175346005436885 0.408052734750422 no 1339 0.430403882291249 2083 22310230 SGTC_2463 5473429 200 µM 0.175017430607455 0.408178776026085 no 1340 0.43053296866555 1983 5399405 SGTC_3218 9131285 49.47 µM 0.174843368388318 0.40824555012867 no 1341 0.430601355064546 2088 17156417 SGTC_2363 9053361 176 µM 0.169775512767489 0.410190851665906 no 1342 0.432593342656974 2109 6469797 YMR079W SEC14 SGTC_1317 1273-0028 910 nM 0.169539700548889 0.410281422653985 no 1343 0.432686073897003 2011 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1419 3993-2473 62.6 µM 0.168991615047676 0.410491950350677 no 1344 0.432901618383494 2028 704026 SGTC_2995 9067767 71.4286 µM 0.167473455022108 0.411075232428322 no 1345 0.433498766182123 1996 11673567 SGTC_232 clozapine 119 µM 0.167160969827937 0.411195314714856 no 1346 0.433621696912302 2035 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2379 9035213 200 µM 0.165312698693679 0.411905740960347 no 1347 0.434348932111166 2151 646551 SGTC_2806 7952793 58.44 µM 0.164394688933671 0.412258706991755 no 1348 0.434710222156289 2037 2972490 SGTC_1336 1486-0901 104 µM 0.163749364983582 0.412506870424155 no 1349 0.434964227187263 2034 5006114 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.163338522824649 0.412664880621835 no 1350 0.435125952168896 2083 616764 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.163011830933882 0.412790536667486 no 1351 0.435254559766569 2106 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_448 monastrol 171 µM 0.162971047494312 0.412806223897451 no 1352 0.435270615314707 2100 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2879 9041815 71.43 µM 0.160579873733119 0.413726224461965 no 1353 0.436212153799029 2133 4942971 SGTC_1330 1469-0054 61.8 µM 0.160443508016855 0.41377870529661 no 1354 0.436265859536098 2146 7102664 SGTC_2900 5328528 85.29 µM 0.159782288838175 0.414033199689143 no 1355 0.436526288140001 2072 795359 SGTC_2014 4013930 200 µM 0.15955834208391 0.414119401981177 no 1356 0.436614498329132 2164 64556 SGTC_2256 7954252 200 µM 0.158914746671729 0.414367159778388 no 1357 0.436868021088149 1998 2972920 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.156421771107776 0.415327173759996 no 1358 0.437850288766372 2120 4000243 SGTC_2083 5306046 65.942 µM 0.154818393648031 0.41594488213395 no 1359 0.438482245007467 2022 539837 SGTC_758 0868-0029 16 µM 0.154047306908091 0.41624202082895 no 1360 0.438786217605833 2173 762687 SGTC_629 3448-6466 76.7 µM 0.153837591242058 0.416322843163532 no 1361 0.438868896550295 2073 573744 SGTC_3355 9151058 44.0485 µM 0.153286165306468 0.416535374116136 no 1362 0.43908630511339 2144 17015728 SGTC_1294 1000-1494 117 µM 0.15310571184245 0.416604929913193 no 1363 0.43915745579434 1991 712797 YDL207W GLE1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.152119204379101 0.41698522536662 no 1364 0.439546458787047 2068 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_62 0180-0423 3.232 µM 0.151750751588145 0.417127282678319 no 1365 0.439691763344303 2087 30102 YGL099W LSG1 SGTC_1416 3966-0321 25.3 µM 0.150069991843824 0.417775438121056 no 1366 0.440354697438996 2056 582530 YLR208W SEC13 SGTC_2028 5153890 36.43 µM 0.149707481641307 0.417915263158158 no 1367 0.440497702606145 2039 2830968 YPR165W RHO1 SGTC_301 4119-0100 24.5 µM 0.149194018615096 0.418113330473887 no 1368 0.440700269812757 2029 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1908 st060353 56.5 µM 0.148735325605143 0.418290287933543 no 1369 0.440881242728651 2166 4227716 SGTC_3188 9110789 49.47 µM 0.148645193943835 0.418325061435306 no 1370 0.440916804761457 2136 849217 SGTC_1797 st048695 56.8 µM 0.148236633084873 0.418482695420112 no 1371 0.441078011074538 2144 592262 YIL048W NEO1 SGTC_2034 5197015 53.07 µM 0.148118929988981 0.418528110932988 no 1372 0.441124455128886 2127 780676 SGTC_1701 st028638 40.4 µM 0.148018191589898 0.418566981512812 no 1373 0.441164205785742 2140 3490878 SGTC_511 blebbistatin 171 µM 0.147863132053026 0.418626813817951 no 1374 0.441225392335986 2130 3476986 A myosin inhibitor. SGTC_2594 a-mangostin 100 µM 0.147497353198912 0.418767963137646 no 1375 0.441369734361628 2130 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1969 st069479 40.1 µM 0.14734155508311 0.418828086788539 no 1376 0.441431217087655 2142 3895485 SGTC_558 k064-0027 21.3 µM 0.145286638720121 0.4196212711902 no 1377 0.442242281775474 2094 5088526 SGTC_1510 1123-0200 71.5 µM 0.144990195573557 0.419735723362639 no 1378 0.44235930639485 2126 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1579 chlormadinone acetate 49.4 µM 0.1448811330833 0.419777832433803 no 1379 0.442402361435659 2152 45114258 A steroidal progestin. SGTC_53 0973-0023 39.979 µM 0.144521121041197 0.419916839745259 no 1380 0.442544489673662 2198 674768 SGTC_2055 5235184 200 µM 0.142776565647529 0.420590586083155 no 1381 0.443233322673369 2071 2836034 SGTC_329 k048-0121 21.3 µM 0.14161480683855 0.421039385901559 no 1382 0.443692135322793 2055 6832902 SGTC_439 amiodarone 34.4 µM 0.141411791001165 0.42111782363518 no 1383 0.443772320000926 2086 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3347 9188721 44.724 µM 0.141212661956833 0.421194762698913 no 1384 0.443850971758108 2076 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2037 5169046 200 µM 0.13934258607784 0.421917465157441 no 1385 0.444589719641853 2083 5718022 SGTC_3258 9138477 49.47 µM 0.139096348635443 0.422012644798793 no 1386 0.444687006772686 2165 4970355 SGTC_454 lyso-paf C-16 6.67 µM 0.135556768884735 0.423381320574215 no 1387 0.446085841662195 2019 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1408 3909-7976 48.8 µM 0.135448808512993 0.423423081039861 no 1388 0.446128518024669 2089 24152374 SGTC_1571 st070080 73.4 µM 0.135106330636827 0.423555561594568 no 1389 0.446263902475087 2126 4315245 SGTC_2588 indole-3-carbinol 100 µM 0.134734496156517 0.42369940793501 no 1390 0.446410898936139 2169 3712 Induces cell cycle arrest. SGTC_3278 9139605 49.47 µM 0.134133844822384 0.423931794883367 no 1391 0.446648368580538 2131 7958859 SGTC_3122 9126309 49.47 µM 0.133153224510537 0.42431124544807 no 1392 0.447036101392312 2199 17591206 SGTC_1920 st075728 45.7 µM 0.131435818610558 0.424975963696032 no 1393 0.447715277637356 2189 3400306 SGTC_3328 9140624 29.0385 µM 0.130697019904738 0.425261979888386 no 1394 0.448007494947385 2165 4904392 SGTC_184 1494-0393 24.714 µM 0.129671596541352 0.425659024206653 no 1395 0.44841312773666 2069 3090647 SGTC_2403 6032726 181.2 µM 0.128495414486121 0.426114535159399 no 1396 0.448878463426963 2084 2881040 SGTC_3050 9093513 49.47 µM 0.127841348361664 0.426367884122792 no 1397 0.449137263627201 2143 25236664 SGTC_747 3448-8087 38.7 µM 0.127452549213151 0.426518497770188 no 1398 0.449291113530215 2071 5168703 SGTC_1606 st000094 49.2 µM 0.125474874712354 0.427284777977893 no 1399 0.4500738074481 2198 1242210 SGTC_953 1188-0045 9.7 µM 0.124284086065594 0.42774629979089 no 1400 0.45054517354189 2120 6144426 SGTC_21 0849-0113 22.993 µM 0.122522295552655 0.428429309756086 no 1401 0.451242694857663 2127 1560156 SGTC_2065 5221596 34.26 µM 0.121302621374326 0.428902278101786 no 1402 0.451725671898046 2132 788581 SGTC_424 splitomicin 100 mM 0.121146248701412 0.428962924092535 no 1403 0.451787598873226 1987 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2187 6125751 200 µM 0.120810661445814 0.429093080508321 no 1404 0.451920502674493 2133 874498 SGTC_2616 abietic acid 100 µM 0.118331760962843 0.430054751838368 no 1405 0.452902396286444 2224 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1263 0774-1208 64.8 µM 0.116437072590305 0.430790062539403 no 1406 0.453653077760023 2206 906585 SGTC_1552 6-methylflavone 10.6 µM 0.116163771893194 0.430896147830216 no 1407 0.453761374084303 2209 689013 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.115291958192001 0.431234587169076 no 1408 0.454106856145936 2176 5282309 SGTC_2075 5212009 200 µM 0.1141287955086 0.431686207190744 no 1409 0.454567847920927 2190 780898 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.113975628975143 0.431745683675665 no 1410 0.454628556395094 2201 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1610 st001799 48.1 µM 0.111907775332811 0.432548808080943 no 1411 0.455448265754282 2030 621897 SGTC_2883 9059145 45.46 µM 0.11162267270493 0.432659559752492 no 1412 0.455561297073788 2161 16476510 SGTC_831 k061-1017 217 µM 0.109351136144787 0.433542154749985 no 1413 0.456461994477825 2175 1240153 SGTC_237 nikkomycin 200 µM 0.109326867674829 0.433551585949039 no 1414 0.456471618496637 2196 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_627 1391-0720 175 µM 0.107756221302953 0.434162049879294 no 1415 0.457094535473986 2129 997839 SGTC_47 0149-0135 24.25 µM 0.10745941932338 0.434277425743141 no 1416 0.45721225877011 2212 5239155 SGTC_3095 9117207 49.47 µM 0.105599211077014 0.435000671802373 no 1417 0.457950175360899 2214 17015229 SGTC_1497 4476-2978 41.3 µM 0.104434723979334 0.435453533431933 no 1418 0.458412183791393 2177 1528379 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.104040326372802 0.435606931376648 no 1419 0.458568673192579 2193 368090 SGTC_1268 0828-0275 2.46 µM 0.103810991883725 0.435696133735792 no 1420 0.458659671670675 2175 745337 SGTC_1780 st038448 24.544 µM 0.103679590010249 0.435747245521622 no 1421 0.458711812081469 2171 728868 YDL195W SEC31 SGTC_1434 4073-0095 163 µM 0.102790137473965 0.436093246753241 no 1422 0.459064766478364 2217 24133745 SGTC_551 k048-0028 34.9 µM 0.101200627419912 0.436711695303413 no 1423 0.459695599333891 2208 6836383 SGTC_1945 st075991 56.6 µM 0.101119559965648 0.436743241288894 no 1424 0.459727775511761 2049 1084980 SGTC_1502 4534-4282 27.7 µM 0.10107033816332 0.436762395290805 no 1425 0.4597473120806 2133 3278949 SGTC_340 k038-0059 454 µM 0.10088479242275 0.436834599250938 no 1426 0.459820957700003 2208 23733424 SGTC_651 3253-0966 34.4 µM 0.10054452251225 0.436967018616857 no 1427 0.459956019020065 2153 781462 SGTC_1070 indatraline 8.81 µM 0.0999593489967797 0.437194761125815 no 1428 0.460188299275051 2116 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2338 7999974 200 µM 0.0998986617838284 0.437218381053164 no 1429 0.460212389389793 2223 315925 SGTC_2451 5856223 45.7 µM 0.0994441678016353 0.437395280693994 no 1430 0.460392807850747 2148 2179896 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0988579912853777 0.437623452718845 no 1431 0.460625511778878 2137 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1291 0993-0025 5.79 µM 0.0987852774278759 0.437651758384949 no 1432 0.460654379111232 2211 4353356 SGTC_1090 efavirenz 20.7 µM 0.0978748469735556 0.438006192901003 no 1433 0.46101583663922 2161 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1778 st046819 58.9 µM 0.0969600737076026 0.438362368188534 no 1434 0.461379050783425 2221 671715 SGTC_490 phenamil 164 µM 0.0952951151678864 0.439010762877697 no 1435 0.46204021126484 2242 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2233 sulbentine 40.3845 µM 0.0946268035881079 0.439271073561339 no 1436 0.462305629587663 2195 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_6 0844-0013 19.835 µM 0.0934208462954654 0.43974086630507 no 1437 0.462784614994553 2244 1584900 SGTC_2424 5537928 59.2 µM 0.0930928657741723 0.439868649109398 no 1438 0.462914892555951 2155 5382802 SGTC_3336 9143619 71.43 µM 0.0927347650604649 0.440008174040188 no 1439 0.463057138739432 2248 45595730 SGTC_1445 4239-0156 97.7 µM 0.0921308120264172 0.440243506010736 no 1440 0.463297054047555 2236 4008346 SGTC_3302 9125395 16.351 µM 0.0895072783098899 0.441266017153946 no 1441 0.46433938477389 2154 17599668 SGTC_1979 st071809 45.3 µM 0.0882272817381722 0.441765032959806 no 1442 0.464848017085214 2218 4976333 SGTC_2743 auranofin 4.32 µM 0.087040585041121 0.442227757743235 no 1443 0.465319626153285 2216 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1153 4055-0057 267 µM 0.0866125488904893 0.442394679866362 no 1444 0.465489745407919 2116 882706 SGTC_2823 7987624 58.44 µM 0.086290836932393 0.442520145263068 no 1445 0.465617611187923 2185 2239440 SGTC_971 1315-0384 26.7 µM 0.0862817158256663 0.442523702514522 no 1446 0.465621236462223 2145 6769120 SGTC_1867 st057372 64 µM 0.0859082811161557 0.442669346838505 no 1447 0.465769664236102 2253 688837 SGTC_3108 9121785 49.47 µM 0.0856332606280106 0.442776613309906 no 1448 0.465878978703259 2267 17140271 SGTC_985 1493-0307 8.71 µM 0.08362547105862 0.443559839757479 no 1449 0.466677107444608 2268 3278274 SGTC_1264 0783-0040 158 µM 0.0820940634927586 0.444157380916557 no 1450 0.467285956918826 2196 2855798 SGTC_463 ikarugamyin 104 µM 0.0819983784357946 0.444194720574692 no 1451 0.467324001467892 2267 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_786 4544-0069 423 µM 0.0815304363070443 0.444377335099431 no 1452 0.467510060384652 2187 748821 YLR208W SEC13 SGTC_2350 9023895 38.85 µM 0.0791452160043052 0.445308350565204 no 1453 0.468458559557484 2210 2997209 SGTC_2062 5245942 200 µM 0.0790898703848405 0.445329957046613 no 1454 0.46848057026824 2266 1376160 SGTC_680 0417-1641 114 µM 0.0789744702580919 0.445375008843319 no 1455 0.468526464703643 2205 2835990 SGTC_1493 4348-0038 111 µM 0.0788464210134111 0.445424999636067 no 1456 0.4685773901614 2258 800424 SGTC_3288 9119690 36.221 µM 0.0785028025195071 0.445559153569271 no 1457 0.468714050508227 2182 17595618 YKL019W RAM2 SGTC_1662 st014054 52 µM 0.0774996687211906 0.445950828005835 no 1458 0.469113027402423 2275 2838777 SGTC_1160 4092-0570 10.5 µM 0.0755850591634557 0.446698535023864 no 1459 0.469874611758758 2221 4994975 SGTC_1302 1159-0335 255 µM 0.0746006586292883 0.447083044103663 no 1460 0.470266225037516 2236 649284 SGTC_1966 st070145 16.1 µM 0.0737304342308473 0.447422997164277 no 1461 0.470612440837118 2271 3748532 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0732282907285771 0.447619177057428 no 1462 0.470812227035753 2250 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1414 3917-0015 5.4 µM 0.0729585515622571 0.447724565375359 no 1463 0.470919550315022 2270 6618702 SGTC_2702 st077768 96.8 µM 0.0717888389810498 0.448181620001821 no 1464 0.471384977552822 2213 6484119 SGTC_3043 9092303 49.47 µM 0.0706666038797515 0.448620187905535 no 1465 0.4718315503034 2232 25236084 SGTC_687 k029-0044 34.9 µM 0.0696857168433934 0.449003568632566 no 1466 0.472221905225358 2283 5829338 SGTC_523 1934-0222 13.7 µM 0.0692805255355334 0.449161951999031 no 1467 0.472383163428823 2265 1361595 SGTC_705 1124-0212 310 µM 0.0690296583362292 0.449260016386609 no 1468 0.472483005930732 2291 9554485 SGTC_3029 9088683 49.47 µM 0.0690293416980977 0.449260140162919 no 1469 0.472483131950466 2223 25236615 SGTC_2226 7298446 200 µM 0.0682010834911788 0.449583929603839 no 1470 0.472812782240217 2298 3283010 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0669329759580461 0.450079733498082 no 1471 0.473317530437183 2230 4330530 SGTC_2135 5326629 150.42 µM 0.0664453728531545 0.450270397041775 no 1472 0.473511623839653 2226 5020077 SGTC_280 3448-3607 3.04 µM 0.0662709692253671 0.450338595487217 no 1473 0.473581047801181 2291 626179 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0658055601860389 0.450520595278899 no 1474 0.47376631472284 2284 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1900 st060200 72.8 µM 0.0656478607495073 0.450582266543294 no 1475 0.473829091950225 2273 688945 SGTC_1121 fusaric acid 630.51 nM 0.0648470643902508 0.450895451066459 no 1476 0.474147884158592 2167 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2360 9040895 200 µM 0.0640924071659286 0.451190618959191 no 1477 0.474448323810552 2217 4914414 SGTC_2022 5136654 200 µM 0.0624209785611335 0.451844458056943 no 1478 0.475113794529277 2239 1713771 SGTC_1446 4239-0190 62 µM 0.0608566478154686 0.452456520385923 no 1479 0.475736687723677 2173 1340085 SGTC_2249 haloperidol 116.36 µM 0.0608411912929345 0.452462568493607 no 1480 0.475742842579014 2282 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1951 sophoraflavanone G 9.2 µM 0.0605043713746114 0.452594368219712 no 1481 0.475876967188506 2291 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3284 9108171 64.8615 µM 0.0594984193150981 0.452988034548954 no 1482 0.476277562226222 2225 8687505 SGTC_2483 5729050 27.16 µM 0.0591878886640006 0.453109566055268 no 1483 0.476401228088524 2285 2865180 SGTC_507 nimesulide 162 µM 0.0590493682484173 0.453163779817441 no 1484 0.476456393253212 2291 4495 A COX2 inhibitor. SGTC_250 brefeldin a 552.239 µM 0.058513093274279 0.453373673953359 no 1485 0.476669966719802 2291 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2958 9077254 16.72 µM 0.0576873092078412 0.453696905300391 no 1486 0.476998851323419 2236 16457351 SGTC_3060 1327-0027 12.5 µM 0.0573435796971306 0.453831458186001 no 1487 0.477135752933156 2306 16000455 YPR107C YTH1 SGTC_2675 theaflavin digallate 100 µM 0.0572437494162166 0.453870537734093 no 1488 0.477175514140123 2301 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_889 0919-1524 82.7 µM 0.0561368271064675 0.45430388323698 no 1489 0.47761640319646 2159 3905452 SGTC_1104 tacrolimus 29.8 µM 0.056046228093536 0.454339353972478 no 1490 0.477652490159119 2306 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2658 polymyxin b sulfate 77.05 µM 0.0554670702364201 0.454566110677147 no 1491 0.47788318184568 2276 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_342 k048-0088 23.3 µM 0.0554434364377889 0.454575364293647 no 1492 0.477892595880645 2307 6820570 SGTC_1830 st055982 50.3 µM 0.0551608010949265 0.454686029710866 no 1493 0.478005178779269 2314 455313 An antimicrobial agent. SGTC_1205 4161-2785 76 µM 0.0548351585592283 0.45481353888598 no 1494 0.47813489502465 2131 3498106 SGTC_666 0272-0154 136 µM 0.054499631339266 0.454944923395829 no 1495 0.478268551151726 2247 6870312 SGTC_1091 telmisartan 47.6 µM 0.0530252715220682 0.455522305990302 no 1496 0.478855886135695 2285 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_726 3448-4391 34.2 µM 0.0523099852571214 0.455802457314961 no 1497 0.479140848563444 2271 1356692 SGTC_1247 0448-0043 5.84 µM 0.0520723746814422 0.455895525508713 no 1498 0.479235512451898 2249 3089013 YGL099W LSG1 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0519727766270087 0.455934537165094 no 1499 0.479275192596348 2332 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2251 lansoprazole 556 µM 0.0515034156930621 0.456118387306541 no 1500 0.479462190068113 2149 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3245 9134821 49.47 µM 0.0506999519203142 0.456433128358495 no 1501 0.479782307481802 2316 17014901 SGTC_742 0kpi-0133 140 µM 0.0506637495191592 0.456447310578668 no 1502 0.479796731613101 2304 2728852 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0499465177678415 0.456728296135729 no 1503 0.480082503860025 2304 803109 SGTC_949 1165-0505 146 µM 0.0496559142030137 0.456842150308851 no 1504 0.480198294230009 2260 6244267 SGTC_2213 7173844 200 µM 0.0477707417987419 0.457580818564234 no 1505 0.480949477293543 2310 892728 SGTC_412 gemfibrozil 100 µM 0.0442496858913874 0.458960866596934 no 1506 0.482352688599304 2330 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2437 5741531 144.16 µM 0.0440364785413409 0.459044447464132 no 1507 0.482437663193979 2316 2262990 SGTC_1997 st073024 93.8 µM 0.0439915363930003 0.459062065773326 no 1508 0.482455575158894 2330 686268 SGTC_675 1309-0189 238 µM 0.0433145453904237 0.459327470823612 no 1509 0.482725398279763 2290 4246530 SGTC_442 cape 100 µM 0.0409415724542476 0.460257904720726 no 1510 0.483671237594815 2327 5281787 SGTC_1223 0764-0573 147 µM 0.0407236110849163 0.460343377557565 no 1511 0.483758119141339 2332 1609797 SGTC_611 3453-1652 23.7 µM 0.040447001196503 0.460451851856881 no 1512 0.483868379674489 2334 1560575 SGTC_3147 9097027 49.47 µM 0.0402353596017341 0.460534850421058 no 1513 0.48395274377931 2289 25236841 SGTC_1080 nisoldipine 24.4 µM 0.0399094272667469 0.460662673249662 no 1514 0.484082667610193 2342 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2926 9010726 65.15 µM 0.0398919013580197 0.460669546605141 no 1515 0.484089653872687 2299 2994293 SGTC_672 1441-0018 53.7 µM 0.0381435965041606 0.461355259967162 no 1516 0.484786595800395 2333 251141 SGTC_1073 triclabendazole 3.09 µM 0.0373562467463489 0.461664108889805 no 1517 0.48510047916967 2279 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2639 lactacystin 53 µM 0.0359142009787747 0.46222983126984 no 1518 0.485675386214607 2314 3870 A proteasome inhibitor. SGTC_2934 9036370 36.88 µM 0.0354751130001525 0.462402103095792 no 1519 0.485850445414948 2317 6462800 SGTC_415 dibenzyl ketone 100 µM 0.0342515466427114 0.462882194364909 no 1520 0.486338281176872 2331 7593 SGTC_2645 abamectin 100 µM 0.0333727399108679 0.463227045553515 no 1521 0.486688673974762 2333 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1636 st007707 68.9 µM 0.0331244314489127 0.463324488911122 no 1522 0.48678767997943 2336 403051 SGTC_247 mechlorethamine 29.705 µM 0.0330960009840931 0.463335645980913 no 1523 0.486799015878498 2333 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2009 4012297 12.05 µM 0.0327463657660497 0.46347285694526 no 1524 0.486938424582633 2293 45595307 SGTC_559 1550-0661 158 µM 0.0308570366351829 0.464214380684382 no 1525 0.487691776695553 2311 5830875 SGTC_986 1493-0483 84 µM 0.0301614461556543 0.464487417424885 no 1526 0.487969148021517 2351 40079 SGTC_372 0155-0182 15.9 µM 0.0292696440168249 0.464837496619126 no 1527 0.488324768545121 2304 771486 SGTC_3049 9092223 49.47 µM 0.028298561995383 0.465218728280288 no 1528 0.488712013751683 2324 8623917 SGTC_960 1222-0186 7.7 µM 0.0279723078599044 0.465346817749376 no 1529 0.488842118813952 2331 3126296 SGTC_1456 k015-0012 13 µM 0.02779646631234 0.465415855760283 no 1530 0.488912242174711 2358 2989616 SGTC_1222 0366-0074 1.18 µM 0.0265352985507757 0.46591103939081 no 1531 0.489415189666021 2356 286520 SGTC_1691 st019933 84.6 µM 0.0253188795950981 0.466388702910786 no 1532 0.489900307509329 2365 6176082 SGTC_2217 6934799 96.0675 µM 0.024969668095475 0.466525840293551 no 1533 0.490039578707635 2353 675606 SGTC_815 1582-0027 36.9 µM 0.0237063143809153 0.46702199970826 no 1534 0.490543434637416 2339 3128206 SGTC_3065 9113888 49.47 µM 0.0235915341692045 0.467067080119936 no 1535 0.490589212513873 2349 16648368 SGTC_2312 7706453 155.7 µM 0.0234260265681249 0.467132084671081 no 1536 0.490655222250514 2355 976098 SGTC_2969 9091408 28.7 µM 0.0228514167694845 0.467357774465619 no 1537 0.49088439703242 2285 4286311 SGTC_404 fumagillin 50 µM 0.0226934802083297 0.467419809133942 no 1538 0.490947388268967 2306 12015870 A methionine aminopeptidase binder. SGTC_2565 isoliquiritigenin 100 µM 0.0212646728932951 0.467981054977644 no 1539 0.491517262205097 2300 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3175 9106517 49.47 µM 0.0207279499919219 0.468191900119717 no 1540 0.491731336468751 2346 41468073 SGTC_2266 7929956 200 µM 0.0206279801115307 0.46823117307344 no 1541 0.491771210155317 2371 2967153 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0205572704930959 0.468258951382532 no 1542 0.491799413231257 2367 65057 A dermal irritant. YDR527W RBA50 SGTC_2430 5571206 200 µM 0.0196421726626065 0.468618461918145 no 1543 0.492164410697092 2372 1731771 SGTC_363 0455-0021 3.06 µM 0.0189201451090188 0.468902139844087 no 1544 0.492452404471876 2371 4597466 SGTC_60 0986-0278 202 µM 0.0187591302950184 0.46896540322855 no 1545 0.492516628690257 2334 3110598 SGTC_3101 9120531 49.47 µM 0.0182509599613322 0.469165070579989 no 1546 0.492719324611598 2375 24824904 SGTC_881 0833-0569 170 µM 0.0179562628893277 0.469280864806741 no 1547 0.492836872468916 2360 5418700 SGTC_25 0118-0223 35.662 µM 0.0170455505791788 0.469638723993769 no 1548 0.493200138467034 2368 5333628 SGTC_86 0417-1630 471.922 µM 0.0167605427711421 0.469750721232182 no 1549 0.493313823889659 2369 3634867 SGTC_321 4534-3890 65.3 µM 0.0156010339569973 0.470206388716336 no 1550 0.493776340402696 2374 699746 SGTC_2472 5377652 49.4 µM 0.015352317339079 0.470304135271216 no 1551 0.493875552094491 2372 1610903 SGTC_3100 9120536 49.47 µM 0.0141022668458643 0.470795436736677 no 1552 0.494374195977259 2385 16421196 SGTC_1570 verbenone 133 µM 0.013744695102426 0.470935979686485 no 1553 0.494516832636555 2383 29025 A natural terpanoid with antifungal properties. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0134557414885653 0.471049555045623 no 1554 0.494632097789241 2372 6708760 SGTC_1042 0350-0096 82 µM 0.0124928489245997 0.47142804404886 no 1555 0.495016203999546 2382 3122515 SGTC_542 3381-0244 89.3 µM 0.0124264239752821 0.471454154991874 no 1556 0.495042701663435 2383 1112843 SGTC_71 0417-1750 47.813 µM 0.0124188825781612 0.47145711944285 no 1557 0.495045710013463 2384 6811472 SGTC_1314 1222-0010 41.1 µM 0.0119909616125864 0.471625333661531 no 1558 0.495216413063551 2365 3526027 SGTC_2568 diosmetin 100 µM 0.011593631480485 0.471781527264434 no 1559 0.495374913830678 2384 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_578 3460-0051 92 µM 0.0113361560030457 0.471882745220578 no 1560 0.495477624933922 2374 2876744 SGTC_153 4077-0274 519.67 µM 0.0107826114949535 0.472100359050517 no 1561 0.495698443734881 2391 3121976 SGTC_2352 9027995 87.8 µM 0.00947006277616668 0.472616391837278 no 1562 0.49622204802972 2354 2997347 SGTC_116 0155-0182 31.788 µM 0.00785922181646685 0.473249761918353 no 1563 0.496864656403378 2381 771486 SGTC_871 0574-0004 149 µM 0.00761843321685444 0.473344443964198 no 1564 0.4969607142797 2376 9551173 SGTC_2744 captopril 92.04 µM 0.00749850988483325 0.473391600356939 no 1565 0.497008555400608 2387 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2885 9057732 51.95 µM 0.00746992882369853 0.473402839090242 no 1566 0.497019957274979 2379 6471414 SGTC_2008 4012253 172 µM 0.00590394239656062 0.474018653232757 no 1567 0.497644681440006 2390 603940 SGTC_3045 9092950 49.47 µM 0.0057646695828619 0.474073424403716 no 1568 0.497700242308227 2392 44120432 SGTC_2648 atorvastatin 78.68 µM 0.00408083862113522 0.474735655243445 no 1569 0.498371985453156 2392 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2939 9044578 71.43 µM 0.00310550290623493 0.475119275312611 no 1570 0.498761085580173 2399 2653634 SGTC_2155 5570423 76 µM 0.00254066440788166 0.475341448755229 no 1571 0.498986422637821 2398 797402 SGTC_2215 7188065 200 µM 0.00223624457450519 0.475461192365348 no 1572 0.499107868233472 2400 940217 SGTC_2727 riluzole 51.77 µM 0.00219025262962262 0.475479283500226 no 1573 0.499126216319903 2400 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2041 5107442 45.335 µM 0.00203156921058751 0.475541702712609 no 1574 0.499189521703846 2401 793005 SGTC_922 1866-0035 480 µM 0.00183098905862177 0.47562060315126 no 1575 0.49926954145771 2396 3156169 SGTC_2809 7964133 12.99 µM 0.000668372035469317 0.476077950249373 no 1576 0.499733358155866 2403 1253665 SGTC_3232 9132874 49.47 µM -0.000629330533106602 0.47658847412412 no 1577 0.499748933458569 2407 3784940 SGTC_3064 1327-0027 10 µM -0.00195963446964566 0.477111863453315 no 1578 0.499218219456288 2398 16000455 YPR107C YTH1 SGTC_1713 st033146 12.748 µM -0.00283397019603961 0.477455880078122 no 1579 0.498869410980769 2412 674619 SGTC_2606 farnesol 9.78 µM -0.00334776516039075 0.477658045986133 no 1580 0.498664437427392 2411 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2239 6685329 187.64 µM -0.00457362712364318 0.478140416185526 no 1581 0.498175393126798 2451 805680 SGTC_623 k072-0108 16.9 µM -0.00506638073691887 0.478334321189511 no 1582 0.497978815162136 2421 5382803 SGTC_92 0063-0024 660.874 µM -0.00515915021369031 0.478370827769343 no 1583 0.497941805979255 2409 3594437 SGTC_708 3448-5400 146 µM -0.00626916161549297 0.478807652672081 no 1584 0.497498982751579 2414 3462195 SGTC_1999 st074831 12.5 µM -0.0066880387855927 0.478972500847485 no 1585 0.497331878446262 2426 17112523 SGTC_207 4185-0010 4.486 µM -0.00688624971200754 0.479050507570695 no 1586 0.497252805548688 2411 3761753 SGTC_3160 9100216 49.47 µM -0.0073065916878688 0.479215937531284 no 1587 0.497085117585892 2420 17191039 SGTC_1258 0671-0043 57.1 µM -0.00761445762760686 0.479337103650047 no 1588 0.496962300264338 2419 4298767 SGTC_1376 2910-0861 41.3 µM -0.00914921725388692 0.479941163875711 no 1589 0.496350041326815 2419 1112859 SGTC_1303 1160-0052 261 µM -0.00920245864247237 0.479962119786898 no 1590 0.496328801979996 2419 3562476 SGTC_2541 muurolladie-3-one 83.07 µM -0.00967131714253276 0.480146665763633 no 1591 0.496141762831067 2484 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1934 st074720 32.6 µM -0.0101273743378749 0.480326177140664 no 1592 0.495959831249737 2417 17250992 SGTC_440 fluspirilene 35.1 µM -0.0110854220475154 0.480703292932069 no 1593 0.495577647023978 2463 3396 An atypical antipsychotic. SGTC_1361 1608-0041 5.61 µM -0.0117542609701468 0.480966577885584 no 1594 0.495310836302266 2428 X1361 SGTC_1745 st081495 74 µM -0.0120598933290347 0.48108689124039 no 1595 0.495188915275717 2433 13842402 YBL026W LSM2 SGTC_1180 1193-0155 285 µM -0.0134428767565605 0.481631329365703 no 1596 0.494637229610611 2449 2921347 SGTC_2768 sulfasalazine 50.2 µM -0.0136920267602617 0.481729415746138 no 1597 0.494537842288048 2434 5384001 An antioxidant and salicylic acid derivative. SGTC_294 k038-0071 157 µM -0.013940617583262 0.481827283088358 no 1598 0.494438678363679 2440 24152826 SGTC_617 3770-0098 35 µM -0.0147890204485225 0.482161297730461 no 1599 0.494100249518925 2433 5962639 SGTC_2874 9043904 71.43 µM -0.0148636562319498 0.482190682303285 no 1600 0.494070477421728 2465 4463428 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0153297932906114 0.48237420554945 no 1601 0.493884536832418 2441 689007 SGTC_3189 9110682 49.47 µM -0.0155582126727456 0.482464138118504 no 1602 0.49379342155035 2444 17122418 SGTC_2882 9058044 58.44 µM -0.0162303264191475 0.482728765811688 no 1603 0.493525320831704 2452 18076804 SGTC_3148 9097893 49.47 µM -0.0163705587500625 0.482783979688613 no 1604 0.493469383657739 2434 17174100 SGTC_2133 5320837 200 µM -0.0165130728194559 0.482840092295981 no 1605 0.49341253645432 2446 2841355 SGTC_3313 9133968 57.047 µM -0.0182737559177062 0.483533360451681 no 1606 0.492710231857184 2441 1494643 SGTC_720 r052-1644 49.9 µM -0.0196265777036281 0.484066067336937 no 1607 0.492170630986487 2469 1422863 YOR257W CDC31 SGTC_112 phenothiazine 287.218 µM -0.0197014846558863 0.484095564633408 no 1608 0.492140753213181 2441 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2050 5263056 171 µM -0.0216478703240063 0.484862053775699 no 1609 0.491364423734475 2447 763468 YGL055W OLE1 SGTC_1002 4049-0206 172 µM -0.0216529061322629 0.484864036957142 no 1610 0.491362415208438 2456 4662749 SGTC_458 nppb 133 µM -0.0225356552815192 0.485211683363275 no 1611 0.491010335206929 2448 4549 A chloride channel blocker. SGTC_722 3534-0461 190 µM -0.0227700392808385 0.485303990936423 no 1612 0.490916853508179 2465 658262 SGTC_3215 9129942 49.47 µM -0.0228989947511341 0.48535477787294 no 1613 0.490865421129384 2456 17682944 SGTC_1672 st016598 6.51 µM -0.0233073398749875 0.485515599274467 no 1614 0.490702558465904 2486 4665860 YNL267W PIK1 SGTC_2322 7413319 38.22 µM -0.0233480950642964 0.485531650303991 no 1615 0.490686303921064 2479 1840400 SGTC_1141 3253-0389 52.6 µM -0.0240049927508257 0.48579036619764 no 1616 0.49042431310825 2425 5402031 SGTC_3329 9141233 27.5565 µM -0.026396300914134 0.486732220758186 no 1617 0.489470622283138 2477 4909101 YNL103W MET4 SGTC_1681 tripelennamine 100 µM -0.026726798562886 0.486862398426988 no 1618 0.48933881930083 2448 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_807 1315-0151 48 µM -0.0273601482639687 0.487111868512035 no 1619 0.48908624170914 2458 4011080 SGTC_732 3970-1727 52.7 µM -0.0277112890389553 0.487250181515389 no 1620 0.488946209905571 2461 1275699 SGTC_2468 5987765 72.9 µM -0.0277297242247603 0.487257443106827 no 1621 0.488938858155689 2506 26772094 SGTC_3309 9129340 25.759 µM -0.0286811557638937 0.487632216212353 no 1622 0.488559442853469 2489 17158987 SGTC_3135 9127742 49.47 µM -0.0294805265980172 0.487947100388043 no 1623 0.488240674857305 2504 3643468 SGTC_2620 irigenin 100 µM -0.0295735653348809 0.487983750235554 no 1624 0.488203573948142 2486 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2053 5265679 138 µM -0.0301355625568799 0.488205134498784 no 1625 0.487979469391657 2458 764595 SGTC_230 MPP+ 141.667 µM -0.0302071937761129 0.488233352026615 no 1626 0.487950905673622 2477 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3214 9129694 49.47 µM -0.0303746306539079 0.488299310295222 no 1627 0.487884138661558 2458 17158655 SGTC_2968 9090663 33.37 µM -0.0312584195109552 0.488647465757265 no 1628 0.487531725306851 2540 25236811 SGTC_1512 0259-0544 12.2 µM -0.0327684151993483 0.489242325949356 no 1629 0.486929632849666 2472 18476 SGTC_1690 st023502 41.2 µM -0.0328643628931905 0.489280125200104 no 1630 0.486891375863216 2457 24207482 SGTC_261 5-fluorouridine 15.376 µM -0.0336431066002934 0.489586920146235 no 1631 0.486580873806443 2490 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_856 0433-0016 11.3 µM -0.0344632696742549 0.489910039381252 no 1632 0.486253865746035 2505 3911780 SGTC_1089 terbinafine 2.25 µM -0.0346063899059712 0.489966425071757 no 1633 0.486196803072645 2473 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2794 7785382 27.27 µM -0.0346744080431188 0.489993222538854 no 1634 0.486169684037631 2451 2205081 SGTC_2546 rhodinyl acetate 100 µM -0.0348257572033693 0.490052850534034 no 1635 0.486109340903789 2476 6708682 SGTC_2780 5215298 71.43 µM -0.0350953454984402 0.490159062506043 no 1636 0.486001856440897 2468 2834131 SGTC_3145 9085516 49.47 µM -0.0351597173953652 0.490184423748124 no 1637 0.48597619160891 2524 25236195 SGTC_2173 5763948 167 µM -0.0352813483767454 0.490232344034441 no 1638 0.485927697955039 2473 2867177 SGTC_1868 st057644 42.7 µM -0.0363048218254135 0.490635578565327 no 1639 0.485519652607646 2474 688665 SGTC_126 0417-1624 672.48 µM -0.0374051379337275 0.491069098716488 no 1640 0.485080988030288 2482 41912 YDL195W SEC31 SGTC_2787 5284540 71.43 µM -0.0387746431729438 0.491608692988713 no 1641 0.484535030721739 2495 736958 SGTC_1876 myriocin 605 nM -0.0390574023585705 0.491720103954123 no 1642 0.484422311514306 2491 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2586 curcumin 80 µM -0.0394181269095699 0.49186223527051 no 1643 0.48427851397823 2508 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_602 3130-1533 38.1 µM -0.0394943685575075 0.49189227584769 no 1644 0.484248121627895 2526 720941 SGTC_2216 7189485 200 µM -0.0403798944356614 0.492241192256016 no 1645 0.483895129545193 2488 731273 SGTC_2368 9071271 200 µM -0.0409082935287022 0.492449395807964 no 1646 0.483684502851949 2503 27209959 SGTC_459 nigericin 15.3 µM -0.0419431886851497 0.492857178432305 no 1647 0.483271993540519 2516 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3124 9127567 49.47 µM -0.0425787431042932 0.493107611439251 no 1648 0.483018670332783 2486 17592030 SGTC_753 1322-0200 289 µM -0.0426539817211649 0.493137258544218 no 1649 0.482988681711751 2536 5403907 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.0428223271023656 0.493203593675117 no 1650 0.482921582929185 2467 4174840 SGTC_283 0987-0079 11.7 µM -0.0429099438924238 0.49323811843448 no 1651 0.482886660986545 2464 411556 SGTC_1151 3909-8316 15.3 µM -0.0430835449820675 0.493306524831554 no 1652 0.4828174681607 2569 800431 SGTC_335 4077-0256 27.6 µM -0.0439120909643043 0.493633010743906 no 1653 0.482487238701389 2563 3121989 SGTC_2904 7225135 42.03 µM -0.0447490117723273 0.493962801058922 no 1654 0.482153683527467 2512 4446116 SGTC_290 2043-6722 48.1 µM -0.0448511896118604 0.494003064727709 no 1655 0.482112961353387 2521 773758 YLR208W SEC13 SGTC_2330 7979373 200 µM -0.0448983821592945 0.494021661198506 no 1656 0.482094153197862 2503 1863007 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.045736934583275 0.494352099307394 no 1657 0.481759962529675 2467 6708561 SGTC_3106 9121286 49.47 µM -0.0468130038635912 0.494776138428007 no 1658 0.481331132406246 2638 15943471 SGTC_1007 4101-0031 70 µM -0.046815853811408 0.494777261495127 no 1659 0.481329996686763 2485 1146276 SGTC_488 nitrendipine 139 µM -0.047114020773592 0.494894759140625 no 1660 0.481211176392933 2480 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1604 st002052 72.4 µM -0.0476183258623755 0.495093489942593 no 1661 0.481010213335188 2601 6254834 YHR062C RPP1 SGTC_1152 3909-8331 15.9 µM -0.0480897417765654 0.495279261255576 no 1662 0.480822360812231 2500 16001939 SGTC_2409 alverine citrate 63.97 µM -0.0489178188393281 0.495605584816997 no 1663 0.480492394240692 2764 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2967 9089538 49.85 µM -0.0497694341593523 0.495941187256241 no 1664 0.480153062246358 2506 728216 SGTC_757 1066-0008 322 µM -0.0502037439618422 0.496112340099897 no 1665 0.479980014034059 2631 6842497 SGTC_1837 st055472 66.5 µM -0.0502173657894428 0.496117708202607 no 1666 0.479974586557013 2606 676091 SGTC_349 k015-0014 24 µM -0.0511257342123641 0.496475680428649 no 1667 0.479612664933795 2498 2196908 SGTC_2713 st079149 53.4 µM -0.0511739546034408 0.496494683329521 no 1668 0.479593452929711 2535 3103253 SGTC_992 3909-8734 162 µM -0.0523993219066353 0.496977583942815 no 1669 0.479105257208341 2528 4288319 SGTC_2869 9037858 32.47 µM -0.0533633903856453 0.497357513386148 no 1670 0.478721186935641 2493 27187042 SGTC_1861 st057647 17.4 µM -0.0549871768295121 0.497997436114815 no 1671 0.478074339872199 2547 688668 SGTC_3120 9124077 49.47 µM -0.0573091273697217 0.498912508907619 no 1672 0.477149474857428 2497 18774327 YGL155W CDC43 SGTC_793 0488-0545 106 µM -0.0584073810286693 0.499345329218648 no 1673 0.476712067800298 2503 292548 SGTC_281 1672-3440 14.9 µM -0.0594946523201909 0.499773822153971 no 1674 0.476279062382255 2544 6833000 SGTC_2857 9024691 58.44 µM -0.0595751110296023 0.499805530897413 no 1675 0.476247020835662 2585 16478292 SGTC_942 3253-1115 227 µM -0.0596467641516292 0.499833769363621 no 1676 0.476218486119377 2570 46497897 SGTC_3 0833-0587 95.581 µM -0.059702302805164 0.499855657124939 no 1677 0.476196368817775 2457 5382644 SGTC_1250 0485-0349 40.2 µM -0.0597262604844524 0.499865098836977 no 1678 0.476186828111843 2538 6842794 YDL195W SEC31 SGTC_2193 5925765 200 µM -0.060410864854886 0.499865098836977 no 1679 0.475914202780139 2562 877370 SGTC_2842 9000675 19.48 µM -0.06102648404798 0.499622483592639 no 1680 0.475669058569632 2571 2989072 SGTC_1496 4469-0713 57.4 µM -0.0611420748023254 0.499576929341722 no 1681 0.47562303048273 2504 746691 SGTC_2788 5282734 71.43 µM -0.0612286572638176 0.499542807246193 no 1682 0.475588553673084 2570 743706 SGTC_520 3584-0023 682 µM -0.0614815386964559 0.499443146847127 no 1683 0.4754878582877 2596 1340790 SGTC_869 0564-0080 44.1 µM -0.0615728467017579 0.49940716243311 no 1684 0.475451500546877 2573 6843321 SGTC_775 4577-0580 57.3 µM -0.0616189805561483 0.499388981118719 no 1685 0.475433130683031 2701 2006902 SGTC_3333 9141820 12.094 µM -0.0621265318801182 0.49918895564797 no 1686 0.475231034209748 2556 1939433 SGTC_1443 4112-3303 14 µM -0.0629839667591056 0.498851041906435 no 1687 0.47488963582129 2523 704433 SGTC_3212 9128307 49.47 µM -0.0643737549828392 0.498303330403814 no 1688 0.474336313580635 2562 27243542 SGTC_69 0096-0274 206.684 µM -0.0647866480972434 0.498140610996172 no 1689 0.474171936195184 2788 6741392 SGTC_3080 9117754 49.47 µM -0.0652043418346379 0.497975999998436 no 1690 0.474005652101934 2520 9550191 SGTC_1109 tnp00067 928.257 nM -0.0652885033431533 0.497942832412711 no 1691 0.473972147909045 2544 676295 SGTC_1463 k081-0032 34.1 µM -0.0655758205018437 0.497829602415697 no 1692 0.473857770056037 2521 977755 SGTC_146 3448-8650 53.125 µM -0.065597197933141 0.49782117770303 no 1693 0.473849260017892 2569 2891488 YIL048W NEO1 SGTC_3209 9113616 49.47 µM -0.0660374280819576 0.497647685961917 no 1694 0.473674013587847 2533 16649353 SGTC_1137 ixabepilone 100 µM -0.0664168698261514 0.497498150878029 no 1695 0.473522969839122 2520 154225 A novel microtubule stabilizer. SGTC_186 3455-3465 67.277 µM -0.0686016864093639 0.496637138891191 no 1696 0.472653338235473 2529 755278 SGTC_270 tamoxifen 5.46 µM -0.068883652222948 0.496526020347369 no 1697 0.472541115621721 2524 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2558 carylophyllene oxide 100 µM -0.0691261343846851 0.496430461940185 no 1698 0.472444609275075 2507 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2635 hydroquinidine 100 µM -0.070426138688703 0.49591815431341 no 1699 0.471927243615543 2546 442912 An experimental heart treatment. SGTC_2447 5741742 33.78 µM -0.0715521403154156 0.495474423330098 no 1700 0.471479164444154 2599 1776504 SGTC_2357 9067248 200 µM -0.0723032817679635 0.495178419079416 no 1701 0.471180276530649 2589 9150235 SGTC_3345 9148410 3.559 µM -0.0723155536463927 0.495173583090209 no 1702 0.471175393541909 2560 4903596 SGTC_673 1082-0474 110 µM -0.0726228750067517 0.495052476942592 no 1703 0.471053111579439 2537 3098046 SGTC_821 1114-0266 29.2 µM -0.0726564212498313 0.495039257399894 no 1704 0.471039763826054 2592 3123235 SGTC_3129 9127257 49.47 µM -0.0731128554713424 0.494859391258004 no 1705 0.47085815592568 2557 837894 SGTC_1655 st012546 55.1 µM -0.0757575541677836 0.493817221730669 no 1706 0.469805992950647 2613 720985 YLR208W SEC13 SGTC_3250 9135583 49.47 µM -0.0762199859747064 0.493635000063313 no 1707 0.469622041215735 2665 7699353 SGTC_1063 disulfiram 1.84 µM -0.0765672410582551 0.493498164757952 no 1708 0.469483910135558 2542 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2378 9074213 121.43 µM -0.0765723975411062 0.493496132859929 no 1709 0.469481859018138 2550 657714 SGTC_585 0kpi-0023 191 µM -0.0777425742488377 0.493035032382392 no 1710 0.469016413607295 2573 64601 SGTC_2096 5468907 200 µM -0.0778969374779668 0.492974207243117 no 1711 0.46895501777441 2620 759785 SGTC_487 nimodipine 119 µM -0.078128983224229 0.492882772466831 no 1712 0.468862726187498 2526 4497 L-type voltage-gated calcium channels inhibitor SGTC_548 1436-0017 110 µM -0.0785418653636655 0.492720082258587 no 1713 0.468698514657144 2550 9677137 SGTC_2040 5100729 123 µM -0.0787548524198132 0.492636158275365 no 1714 0.468613807501752 2543 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2122 5258151 111.688 µM -0.0789351597312842 0.492565111452966 no 1715 0.468542098529267 2587 2173356 SGTC_2873 9040596 71.43 µM -0.0814505855465774 0.491573979191837 no 1716 0.467541810631916 2668 6463863 SGTC_568 1193-0097 7.48 µM -0.0821824345536422 0.49128562432723 no 1717 0.467250820693073 2560 3646150 SGTC_2982 9019404 25.97 µM -0.0826635980031074 0.491096044221396 no 1718 0.467059515178174 2574 22333232 SGTC_2370 9071495 200 µM -0.0829418087068001 0.490986429132252 no 1719 0.466948905004251 2614 21791103 SGTC_1365 1672-3266 55.4 µM -0.0829631371340951 0.490978025754374 no 1720 0.46694042541757 2559 6415873 SGTC_1939 st074455 53.6 µM -0.083145681020897 0.490906103819529 no 1721 0.466867851683426 2573 1644229 SGTC_265 mycophenolic acid 32.932 µM -0.0837901886785151 0.490652171441905 no 1722 0.466611624443853 2739 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1384 3089-0840 101 µM -0.0841022624041217 0.49052921751127 no 1723 0.466487562940393 2535 1069836 SGTC_1101 ebselen 5.29 µM -0.0844457253038731 0.490393897600279 no 1724 0.466351026777633 2550 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0857543873266883 0.489878312066288 no 1725 0.465830833243277 2553 15053 SGTC_658 3253-0951 102 µM -0.0869873547320901 0.489392564090515 no 1726 0.465340781733359 2600 1184878 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0870306505404997 0.489375507269829 no 1727 0.465323574462647 2538 5355888 SGTC_2707 st078556 66.6 µM -0.0875985893307851 0.489151763862331 no 1728 0.465097861710792 2605 17250899 SGTC_3207 9114163 49.47 µM -0.0887309822506428 0.488705660112374 no 1729 0.464647854683009 2629 849233 SGTC_1389 3405-0187 19 µM -0.0888145623494527 0.488672734465706 no 1730 0.464614642173307 2605 799890 SGTC_56 0957-0365 83.25 µM -0.0889945874856211 0.488601815405204 no 1731 0.464543105806987 2542 6752360 SGTC_894 0960-0238 55.9 µM -0.0901348314448149 0.488152636426469 no 1732 0.464090035184776 2533 6741907 YDL195W SEC31 SGTC_554 4483-2211 187 µM -0.0901713382522906 0.488138255459356 no 1733 0.464075530141128 2652 747107 SGTC_685 1278-0033 54.9 µM -0.0905188786482109 0.488001351165077 no 1734 0.463937446271981 2573 3590572 SGTC_1587 estradiol valerate 56.1 µM -0.0910263701373542 0.487801440936473 no 1735 0.463735818847294 2579 13791 A steroid. SGTC_2520 obtusaquinone 4.71 µM -0.0934680199944798 0.486839673901962 no 1736 0.462765877397394 2662 5967872 SGTC_2726 cimetidine 79.27 µM -0.0953146132532934 0.486112350471782 no 1737 0.462032467900715 2579 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2515 chrysin 20.77 µM -0.096533898919741 0.485632131804722 no 1738 0.461548276095051 2669 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_842 0271-0008 11.1 µM -0.0971555575881297 0.485387297980836 no 1739 0.461301430461071 2696 1221709 SGTC_759 3486-0358 89.3 µM -0.0975708587607106 0.485223738981556 no 1740 0.461136532702534 2572 875103 SGTC_1178 0988-0033 191 µM -0.0983196984001995 0.484928828075084 no 1741 0.46083921845083 2703 5392207 SGTC_769 0302-0231 76 µM -0.0986915963044415 0.484782368865845 no 1742 0.460691570733886 2629 571869 YER009W NTF2 SGTC_2854 9024559 71.43 µM -0.0990273738521822 0.484650136180717 no 1743 0.460558267865709 2645 3163529 SGTC_2073 5212005 126 µM -0.0990413416220379 0.484644635564371 no 1744 0.460552722791037 2570 691789 SGTC_700 3453-2283 142 µM -0.0991761690981688 0.484591539606604 no 1745 0.460499197932052 2693 565664 SGTC_964 1287-0107 19.4 µM -0.099394034452535 0.484505743357355 no 1746 0.460412709564081 2669 51516812 YPR165W RHO1 SGTC_1240 0356-0016 42.1 µM -0.101259764974708 0.483771040988773 no 1747 0.459672127436311 2651 4305613 SGTC_3041 9091929 49.47 µM -0.102328200429065 0.483350328534826 no 1748 0.459248086042454 2684 25236887 SGTC_948 3448-0295 75.3 µM -0.102355732948292 0.483339487436224 no 1749 0.459237159528034 2595 678569 SGTC_1500 4488-1866 171 µM -0.102363495330826 0.483336430952636 no 1750 0.45923407896607 2717 2900003 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.103127089269683 0.483035766181423 no 1751 0.458931052757275 2580 688662 SGTC_1629 st005085 44.9 µM -0.105737829877868 0.482007862153358 no 1752 0.457895182340588 2598 24207091 SGTC_2166 5933061 31.504 µM -0.106370929142523 0.481758615283588 no 1753 0.457644028688732 3009 2877375 SGTC_3128 9127691 49.47 µM -0.10713896807911 0.481456253164575 no 1754 0.457339366506504 2755 41316314 SGTC_236 1509-0011 5.31 µM -0.107421477410631 0.481345037362719 no 1755 0.457227308290458 2657 3107280 SGTC_3067 9117431 49.47 µM -0.107852816633734 0.481175234314926 no 1756 0.457056222792001 2643 17150885 SGTC_180 1486-1293 102.781 µM -0.10849020459738 0.48092432340229 no 1757 0.456803425125783 2614 4140536 SGTC_785 1270-0111 65.3 µM -0.108819293741123 0.480794778791115 no 1758 0.456672910251066 2590 6741994 SGTC_2957 9076800 11.52 µM -0.108957630066722 0.480740323860418 no 1759 0.456618048248964 2645 16459615 SGTC_3255 9139072 49.47 µM -0.110275484887744 0.480221579562473 no 1760 0.456095449448119 2666 17646060 SGTC_3158 9100007 49.47 µM -0.110905642992107 0.479973543595281 no 1761 0.455845585375308 2631 19297233 SGTC_1787 fluconazole 80 µM -0.111218308143816 0.479850478617044 no 1762 0.455721616950243 2624 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1557 sumaresinolic acid 42.3 µM -0.111415340622888 0.479772927635117 no 1763 0.455643497870098 2587 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1878 temozolomide 1 mM -0.111561579117359 0.479715369402116 no 1764 0.455585518605465 2586 5394 DNA alkylating agent. SGTC_1767 st044992 70.3 µM -0.112531141488084 0.479333768618974 no 1765 0.455201139607321 2637 9600693 SGTC_348 k064-0012 10.7 µM -0.112936864755118 0.479174089479054 no 1766 0.455040304718868 2573 5066323 SGTC_883 0850-0245 24.6 µM -0.112963829379425 0.479163477220839 no 1767 0.455029615791584 2791 6823229 YPR165W RHO1 SGTC_1175 0741-0056 27.6 µM -0.113414061320187 0.478986285113333 no 1768 0.454851146158552 2737 765927 SGTC_1947 st076332 61.6 µM -0.113811673859749 0.478829805212232 no 1769 0.454693542162798 2650 24208416 SGTC_2405 ticlatone 3.52 µM -0.115164212924183 0.478297539784526 no 1770 0.454157481924085 2563 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.115308693032772 0.478240684720886 no 1771 0.454100224140721 2722 688798 SGTC_152 4469-0003 551.229 µM -0.115374761531868 0.478214685934961 no 1772 0.454074041367641 2614 697280 SGTC_18 0111-0177 500 nM -0.116356957958731 0.477828190272969 no 1773 0.453684823096682 2613 721752 SGTC_453 enantio-paf c16 10 µM -0.116374969584239 0.477821102866833 no 1774 0.453677685983639 2641 13871343 A lipid and platelet activating factor SGTC_2162 5663267 200 µM -0.116708685526247 0.47768979003691 no 1775 0.45354545363112 2620 6456493 SGTC_1560 lithocholic acid 53.1 µM -0.116944774419927 0.477596893627336 no 1776 0.453451908348577 2611 9903 A bile acid which acts as a detergent. SGTC_486 niguldipine 82 µM -0.11751484883787 0.47737258540731 no 1777 0.453226038950149 2586 1236 A calcium channel blocker. SGTC_950 1165-0508 94.1 µM -0.118076094582559 0.477151758023837 no 1778 0.453003682344588 2683 6148369 SGTC_3066 9117245 49.47 µM -0.118129272293161 0.477130835119422 no 1779 0.452982614947586 2669 17176980 SGTC_317 4495-0002 170 µM -0.119858840218705 0.476450366953394 no 1780 0.452297485048845 2662 15991618 SGTC_235 0330-0087 5 mM -0.120034020245231 0.47638144924099 no 1781 0.452228099260987 2624 46494818 YHR062C RPP1 SGTC_984 1492-0255 2.91 µM -0.120104502095181 0.476353721120001 no 1782 0.452200183027026 2759 1585198 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.120329164961309 0.476265337724375 no 1783 0.452111200829053 2721 6708739 YPR165W RHO1 SGTC_2020 4017018 200 µM -0.121100016426693 0.475962090147478 no 1784 0.451805908083031 2709 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_812 4251-0442 148 µM -0.121108032547216 0.475958936734548 no 1785 0.45180273347886 2596 5723007 SGTC_2344 7990960 76.95 µM -0.121228322878603 0.475911616633158 no 1786 0.451755095569878 2654 140813 SGTC_2423 st077119 87.2 µM -0.122066393844388 0.475581943715841 no 1787 0.451423218317212 2561 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_125 0133-0007 11.75 µM -0.124200984442826 0.474742333445885 no 1788 0.450578071401305 2730 26541 SGTC_899 1083-0020 478 µM -0.125044526955567 0.474410568938369 no 1789 0.450244149771845 2808 767123 SGTC_1401 3807-4679 7.6 µM -0.127230126483409 0.473551057736103 no 1790 0.449379130824034 2625 3291456 SGTC_2070 5230947 200 µM -0.127595926121982 0.473407214898708 no 1791 0.449234377631808 2650 2835538 SGTC_266 formosanin C 406 nM -0.130212913584865 0.472378243140153 no 1792 0.448198989001623 2654 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1514 1189-1591 158 µM -0.131486865115855 0.47187740516451 no 1793 0.447695088241473 2841 767698 YMR146C TIF34 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.132563290566632 0.471454256703204 no 1794 0.447269383005818 2634 1377 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.132983531059033 0.47128906669212 no 1795 0.447103202560391 2710 1273210 SGTC_1513 0337-0559 19 µM -0.133382774394146 0.471132134912511 no 1796 0.446945333859959 2659 775073 SGTC_1721 st082152 9.2685 µM -0.13360435741436 0.471045038540451 no 1797 0.446857719183178 2628 5296051 SGTC_1475 4092-1048 11.7 µM -0.133892477704279 0.470931790815626 no 1798 0.446743799324165 2683 2881759 SGTC_2307 7538926 6.34 µM -0.134236420225767 0.470796604845181 no 1799 0.446607813672402 2710 96582 SGTC_100 0086-0128 49.5915 µM -0.134245328582454 0.470793103476744 no 1800 0.446604291630348 2678 93297 SGTC_1085 doxorubicin 7.67 µM -0.134372504530086 0.47074311808995 no 1801 0.446554011319518 2690 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1922 5578187 25 µM -0.134638811346393 0.470638450034004 no 1802 0.446448726981982 2870 1350412 SGTC_2991 9074669 71.4286 µM -0.135602009605256 0.470259895828748 no 1803 0.446067958347127 2783 17333109 SGTC_867 0518-0118 155 µM -0.137117561071721 0.469664311442843 no 1804 0.44546893592302 2667 6848158 SGTC_1674 st016616 23.6 µM -0.137320075846561 0.469584731900771 no 1805 0.445388901261558 2614 625830 SGTC_3289 9119912 71.43 µM -0.138212391590004 0.469234104944324 no 1806 0.445036281007941 2757 17014829 SGTC_145 3737-0113 38.366 µM -0.138731129989072 0.469030282589423 no 1807 0.444831308892104 2767 6849351 SGTC_1653 st012112 65 µM -0.139329621912519 0.468795133618738 no 1808 0.444594841632846 2786 720429 SGTC_2998 9066762 71.4286 µM -0.140159081859532 0.468469254749647 no 1809 0.444267150328641 2788 4945196 SGTC_704 1310-0270 142 µM -0.140211275660218 0.468448749512859 no 1810 0.444246531611723 2728 5718033 SGTC_1529 apigenin 74 µM -0.140426562100524 0.468364171398748 no 1811 0.444161486130438 2854 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_447 ml7 120 µM -0.140691974313315 0.468259902680271 no 1812 0.444056642799733 2714 4216 Selective myosin light chain kinase inhibitor. SGTC_735 3076-0345 636 µM -0.141876113376104 0.467794733447406 no 1813 0.443588931100301 2769 2888990 SGTC_2334 9017922 200 µM -0.142297172772409 0.467629337868428 no 1814 0.443422639801907 2803 3163164 SGTC_1462 k081-0014 26.5 µM -0.142313517617716 0.467622917591831 no 1815 0.443416184843136 2676 3270634 SGTC_2917 7979103 53.79 µM -0.142809507860284 0.467428095989736 no 1816 0.443220313933373 2791 2980565 SGTC_2741 miltefosine 3.04 µM -0.143203137867807 0.467273486344236 no 1817 0.443064875852717 2689 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1988 st071872 53.4 µM -0.143465272665893 0.467170528007912 no 1818 0.442961367947909 2650 16414116 SGTC_1310 1188-0297 994 nM -0.14371005640533 0.467074386606888 no 1819 0.442864714886514 2703 1588352 SGTC_2316 5844804 197.44 µM -0.144323746589425 0.466833361757408 no 1820 0.442622413770894 2769 776813 SGTC_144 4161-2749 112.381 µM -0.144965068521469 0.466581497624284 no 1821 0.442369225842587 2652 797501 YMR168C CEP3 SGTC_1723 st034307 2.5525 µM -0.145227366288725 0.46647849018397 no 1822 0.442265679902221 2737 867466 SGTC_2475 5812728 15.03 µM -0.145478061447502 0.466380041323898 no 1823 0.442166717950256 2651 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_614 0462-0418 107 µM -0.145510116090689 0.466367453502323 no 1824 0.442154064635108 2684 5188303 SGTC_813 k007-0158 173 µM -0.146560600720058 0.465954948085556 no 1825 0.441739426926646 2744 6523916 SGTC_2428 5615643 7.78 µM -0.14663818782772 0.465924482542944 no 1826 0.441708804977311 2750 2253075 SGTC_1171 0368-0077 21.4 µM -0.147232955855486 0.465690946126786 no 1827 0.441474074516295 2674 3239779 SGTC_1468 k284-1086 134 µM -0.148129159374079 0.465339073024322 no 1828 0.441120418719338 2691 15996457 SGTC_2283 7944793 200 µM -0.148132198820661 0.465337879703504 no 1829 0.441119219386335 2715 2970533 SGTC_3164 9100705 49.47 µM -0.148512703916726 0.46518849160079 no 1830 0.440969080427665 2814 17174235 SGTC_2185 6113692 200 µM -0.150149087824026 0.464546095709154 no 1831 0.440323496222514 2779 874150 SGTC_2195 6536160 144.242 µM -0.150428718527999 0.464436330168734 no 1832 0.440213192474634 2667 3834386 SGTC_1485 3909-9022 254 µM -0.150662929076827 0.464344395825412 no 1833 0.440120808832098 2682 714516 SGTC_3213 9129884 49.47 µM -0.15127764964969 0.464103109475182 no 1834 0.439878349680599 2772 17190742 SGTC_1120 ficusin 1.78878 µM -0.152210157104752 0.463737112598285 no 1835 0.43951059154882 2821 6199 A DNA cross-linker. SGTC_983 1491-0821 12.2 µM -0.153611700017473 0.46318708330964 no 1836 0.438957955580237 2816 46495113 SGTC_2306 7482397 179.52 µM -0.154013796348018 0.463029295335361 no 1837 0.43879942873214 2802 891448 SGTC_1998 st075797 76.8 µM -0.154097886079407 0.46299629813544 no 1838 0.438766277518552 2635 24208315 SGTC_2118 5526350 200 µM -0.155456576477245 0.462463177183021 no 1839 0.438230692325397 2826 743594 SGTC_2585 alliin 100 µM -0.156734260443225 0.461961902911263 no 1840 0.437727142418605 2838 87310 A garlic compound which reacts with lipids. SGTC_1926 methyl fluorone black 53.6 µM -0.157786249522476 0.461549220920395 no 1841 0.437312617106119 2677 72721 Reacts with homocysteine. SGTC_1034 k072-0165 12.7 µM -0.15798370694412 0.461471765475966 no 1842 0.43723481872626 2852 5835461 SGTC_2777 climbazole 1.536 µM -0.158117654962991 0.461419223317703 no 1843 0.437182044482559 2704 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_127 0180-0333 59.125 µM -0.158216771368383 0.461380344565766 no 1844 0.437142994282314 2655 771601 SGTC_178 4092-0806 87.505 µM -0.159117993003745 0.46102685425114 no 1845 0.436787956227541 2677 2169044 SGTC_3044 9093193 49.47 µM -0.159412649702929 0.46091128636232 no 1846 0.436671886664928 2800 25236277 SGTC_3025 9087895 49.47 µM -0.16107629299719 0.460258847743743 no 1847 0.436016655929713 2787 17173641 SGTC_802 4112-3352 742 µM -0.161121973322807 0.460240934582107 no 1848 0.435998667069398 2836 704594 SGTC_2937 9044753 11.33 µM -0.161651332526263 0.460033356646571 no 1849 0.43579021568316 2686 6465530 YGL099W LSG1 SGTC_930 2810-3379 265 µM -0.161753898066655 0.4599931388189 no 1850 0.435749829423844 2895 1015764 SGTC_900 1112-0045 141 µM -0.162461110879706 0.459715838880372 no 1851 0.43547137520693 2721 56211 YIL048W NEO1 SGTC_861 0443-0273 110 µM -0.162878228347173 0.459552295241224 no 1852 0.435307156580552 2776 6149169 SGTC_782 0083-0095 30.5 µM -0.163558349384402 0.459285647711941 no 1853 0.435039417715493 2677 3591729 An indicator and reagent. SGTC_1663 st014140 55.4 µM -0.164942313746343 0.458743108797529 no 1854 0.434494693473164 2705 4207120 SGTC_2877 9040724 71.43 µM -0.165169988341487 0.458653863595886 no 1855 0.434405093314263 2882 6463895 SGTC_1744 st037937 38.9 µM -0.165204125923833 0.458640482328915 no 1856 0.434391658935728 2850 1016152 SGTC_660 4031-1742 102 µM -0.165488904686769 0.458528856431588 no 1857 0.434279591103052 2682 6738706 SGTC_1961 st076550 68.7 µM -0.165531724740817 0.458512072362355 no 1858 0.434262740757233 2814 1579337 SGTC_1214 0358-0031 63.7 µM -0.165613958521859 0.458479839600813 no 1859 0.43423038084232 3000 4301366 SGTC_1010 4112-3296 15.2 µM -0.166036722325194 0.458314135313355 no 1860 0.434064025506747 2854 704384 SGTC_1476 4112-3294 3.34 µM -0.166044007216009 0.458311280029091 no 1861 0.434061159042739 2809 704369 SGTC_3072 9116419 49.47 µM -0.168075462128278 0.457515143744053 no 1862 0.433261956552658 2782 17170162 SGTC_2426 5582046 32.21 µM -0.168622209215256 0.457300900088849 no 1863 0.43304690514152 2853 2251934 SGTC_1959 st077091 55.8 µM -0.168887350024682 0.457197008734196 no 1864 0.432942624742309 2679 821356 YKL052C ASK1 SGTC_1355 1499-0035 1.68 µM -0.169089498335812 0.45711780198756 no 1865 0.432863122552751 2719 1548538 SGTC_2681 menadione 3.18 µM -0.169216479331013 0.457068048539667 no 1866 0.432813184038661 2755 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_204 PMA1.184 62.41 µM -0.171095787046488 0.456331780919667 no 1867 0.432074224239406 2670 2252213 YGL008C PMA1 SGTC_967 1306-0166 352 µM -0.171948259250065 0.455997852057979 no 1868 0.431739103079417 2796 4437607 SGTC_428 3448-4153 16.5 µM -0.172313655493913 0.455854729207523 no 1869 0.431595474696102 2663 3834874 SGTC_1187 1391-0724 117 µM -0.174728122066043 0.45490914638586 no 1870 0.430646634737378 2753 6997986 SGTC_792 4534-1957 155 µM -0.174944802208816 0.454824299878919 no 1871 0.430561503005777 2779 1717904 SGTC_2138 5575593 77.673 µM -0.17588518900831 0.454456091935839 no 1872 0.430192070706828 2708 762213 SGTC_961 1252-1571 372 µM -0.176201472970839 0.454332259899841 no 1873 0.430067831814746 2851 6813498 SGTC_854 0422-0053 192 µM -0.177436594124157 0.453848725782594 no 1874 0.429582732683676 2730 3596728 SGTC_1996 st072960 66.8 µM -0.177535679342219 0.453809938142633 no 1875 0.429543821135673 2710 1719405 SGTC_2543 pimpinellin 60.67 µM -0.178213401310965 0.453544650706862 no 1876 0.429277692735308 2733 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1117 retinoic acid 1.10837 µM -0.180082952778909 0.452812941436927 no 1877 0.428543722764898 2883 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1757 st041620 31.8375 µM -0.181924471243414 0.452092360386683 no 1878 0.427820999838558 2799 5289815 SGTC_452 diindolylmethane 8 µM -0.182023432090329 0.452053641728954 no 1879 0.42778216846592 2834 3071 Inhibits expression of several cancer promoting factors. SGTC_3266 9136860 49.47 µM -0.183691981272473 0.451400886996848 no 1880 0.427127549942588 2724 4871271 YPR165W RHO1 SGTC_3237 9133362 49.47 µM -0.183773396257623 0.45136903990968 no 1881 0.427095613685031 2829 43845137 SGTC_325 2810-4341 181 µM -0.185715400542028 0.45060947963039 no 1882 0.426333975268805 2855 774970 SGTC_3252 9135871 49.47 µM -0.186514291416811 0.450297068308047 no 1883 0.426020736282921 2872 17682838 SGTC_1693 xanthone 101.9 µM -0.186610523121195 0.450259438366651 no 1884 0.425983007715225 2777 7020 An insecticide. SGTC_3057 9095946 49.47 µM -0.186693456413215 0.450227008925474 no 1885 0.425950493461872 2715 24540043 SGTC_537 1334-0398 209 µM -0.187271861200281 0.450000844303938 no 1886 0.425723742089077 2850 5846986 SGTC_67 0335-0847 266 µM -0.189307224599338 0.449205117423676 no 1887 0.424926016646977 3127 4552207 YOR254C SEC63 SGTC_928 2764-0428 58.7 µM -0.189350902884553 0.449188043591755 no 1888 0.424908901056152 2863 662578 SGTC_3115 9123671 49.47 µM -0.191243142410834 0.448448458336869 no 1889 0.424167552288836 2715 3286988 SGTC_917 harmaline 728.087 nM -0.191388711241621 0.448391569882624 no 1890 0.424110531859525 2857 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_814 3342-0569 96 µM -0.191687627278569 0.448274756505006 no 1891 0.423993449133014 2735 4346283 SGTC_1352 1496-0991 99 µM -0.192548715513615 0.44793827699585 no 1892 0.423656206139321 2739 3000039 SGTC_387 norethindrone acetate 66.7 µM -0.192654314439463 0.447897015650919 no 1893 0.423614852435335 2805 541197 SGTC_378 3970-0959 8.33 µM -0.193334901878821 0.4476310989044 no 1894 0.423348347091459 2871 6615653 SGTC_904 1141-0088 396 µM -0.195676910726027 0.446716217967229 no 1895 0.422431528802102 2792 1378119 SGTC_2457 5731572 11.68 µM -0.19726436542914 0.446096256526446 no 1896 0.421810331836255 2916 2865357 SGTC_1831 st055328 12 µM -0.197506190752887 0.446001826066361 no 1897 0.421715718669173 2907 1103068 SGTC_926 2268-1401 59.4 µM -0.197917224102079 0.44584132853164 no 1898 0.421554913926073 2748 2931578 SGTC_135 0933-0004 26.348 µM -0.198057305831959 0.445786632387149 no 1899 0.421500114044954 2863 21230617 YGL099W LSG1 SGTC_1385 3091-4834 14.1 µM -0.198240434956094 0.445715129564846 no 1900 0.421428476344473 2867 4072814 SGTC_3178 9107506 49.47 µM -0.198264398977679 0.445705772935906 no 1901 0.421419102127352 2890 8897194 SGTC_168 3970-0862 530.542 µM -0.198873873453663 0.445467816940683 no 1902 0.421180703620475 2837 3135186 SGTC_1196 1588-0294 184 µM -0.199003551389986 0.44541718955488 no 1903 0.421129983274866 2810 6144269 SGTC_581 0958-0271 211 µM -0.199079085314791 0.445387700868762 no 1904 0.42110044063515 2743 4591145 SGTC_1625 st003711 30.1 µM -0.199567241078006 0.445197130589216 no 1905 0.420909525093983 2956 24207034 YER133W GLC7 SGTC_1975 st070967 30.8 µM -0.199694619439169 0.445147405653888 no 1906 0.420859711043068 2851 261391 SGTC_2678 equilin 100 µM -0.200302072317795 0.444910284992544 no 1907 0.42062217095787 2864 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1092 toremifene 6.32 µM -0.201205763440766 0.444557563533826 no 1908 0.42026884253873 2751 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2580 diallyl disulphide 81.36 µM -0.20127288105601 0.444531368473376 no 1909 0.420242603210415 2785 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_706 4262-0057 46.9 µM -0.203035454533192 0.443843547915643 no 1910 0.419553660298006 2764 883298 SGTC_1667 st014849 34.6 µM -0.203092846464018 0.443821154319684 no 1911 0.419531231457405 2723 5348460 SGTC_2090 5301565 104.445 µM -0.203424949766509 0.443691575391238 no 1912 0.419401450193865 2788 2056344 SGTC_1084 voriconazole 435 nM -0.203790864924909 0.443548810839979 no 1913 0.419258465888669 2800 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_693 4161-2696 114 µM -0.20498737370229 0.443082035185673 no 1914 0.418790994943797 2880 805759 SGTC_228 caffeine 993.056 µM -0.206267227254306 0.442582832947795 no 1915 0.418291088461282 2899 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1987 st072290 61.9 µM -0.206649528083476 0.442433735539011 no 1916 0.418141788605332 2820 54697379 SGTC_3298 9116858 71.43 µM -0.206745822848763 0.442396181843694 no 1917 0.418104184491274 2913 2506942 SGTC_737 1950-0117 57.9 µM -0.208062325060508 0.44188281530385 no 1918 0.41759015181719 2834 5393513 SGTC_1763 st044482 94.5 µM -0.210699442133802 0.440854772919772 no 1919 0.416560904973238 2919 88505 SGTC_1846 st056244 14.8 µM -0.212686029188209 0.440080593121845 no 1920 0.415785932275612 2854 5393182 SGTC_256 clotrimazole 625 nM -0.2129750866733 0.439967965444427 no 1921 0.415673197423619 2792 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1872 amphotericin b 148 nM -0.213274861651695 0.439851166959579 no 1922 0.415556289989872 2912 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3104 9120930 49.47 µM -0.213796343417348 0.439647999438989 no 1923 0.415352938280608 2862 17014836 SGTC_2755 lomerizine 42.69 µM -0.214156371981992 0.439507742806904 no 1924 0.415212558440073 2817 3949 A calcium channel blocker. SGTC_1032 k061-1018 98.7 µM -0.215434886667801 0.439009732237343 no 1925 0.414714136442912 2990 4005393 SGTC_608 k048-0125 159 µM -0.216130122241897 0.438738962624591 no 1926 0.414443160201588 2890 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2916 7875993 68.79 µM -0.217892400020864 0.438052746613116 no 1927 0.413756474396893 2799 1299250 SGTC_2035 5154463 94.595 µM -0.218225942818105 0.437922888775651 no 1928 0.413626536353711 2922 2769623 SGTC_356 1634-0012 32.5 µM -0.220650657091003 0.436979079325776 no 1929 0.412682227185995 2861 735457 SGTC_566 0958-0068 16.5 µM -0.222067824101486 0.436427618934458 no 1930 0.412130542575451 2964 6815365 SGTC_337 1315-0038 354 µM -0.223064156697378 0.436039991195369 no 1931 0.411742787166748 2815 1626437 SGTC_2909 7941780 10.49 µM -0.2236291392748 0.435820209416464 no 1932 0.411522943984147 2866 1243215 SGTC_2971 9092186 9.93 µM -0.22525438310381 0.435188090075184 no 1933 0.410890692367624 2770 25236400 SGTC_2347 9049783 174.81 µM -0.227209715103775 0.434427806438949 no 1934 0.410130336839105 2975 6467988 YPL169C MEX67 SGTC_913 3487-1245 167 µM -0.227455893003858 0.434332103232624 no 1935 0.41003463133527 2773 4016153 SGTC_1287 0971-0001 34.6 µM -0.228582370897059 0.433894227048447 no 1936 0.409596763906832 2818 4665869 SGTC_752 1896-0090 130 µM -0.228604822735769 0.433885500557817 no 1937 0.409588037912163 2806 772567 SGTC_1077 5-fluorocytosine 377 nM -0.228710751343187 0.43384432908623 no 1938 0.409546868950002 2887 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1333 1482-0047 286 µM -0.229562639136389 0.433513250384607 no 1939 0.409215820597217 2928 3811116 SGTC_495 decylubiquinone 155 µM -0.229766070935929 0.433434195295411 no 1940 0.409136775430595 2880 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_450 aminopyrene 156 nM -0.231874740976848 0.432614908099789 no 1941 0.408317651839888 2906 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2892 9047358 58.44 µM -0.232052046904073 0.432546032106066 no 1942 0.408248794653272 2874 6466771 SGTC_3097 9117246 49.47 µM -0.232286388668183 0.432455003201876 no 1943 0.408157791808069 2822 16423892 SGTC_1950 st077106 7.18 µM -0.23332744015315 0.432050655284031 no 1944 0.407753576199977 2912 13831864 SGTC_1447 4239-0816 81.9 µM -0.23371603979428 0.431899740087266 no 1945 0.407602717313569 2824 1341554 SGTC_427 1354-0053 47.3 µM -0.234829230401896 0.431467480360595 no 1946 0.407170639724454 3061 6813657 SGTC_3316 9136639 10.545 µM -0.235846342169738 0.431072600447098 no 1947 0.406775953224486 2918 4903665 SGTC_1854 st056233 32.9 µM -0.237997273855483 0.430237757612382 no 1948 0.40594160430567 2835 5393174 SGTC_460 trequinsin 123 µM -0.239684167644139 0.429583240105022 no 1949 0.405287554808786 2901 5537 A vasodilator. SGTC_2868 9035608 32.47 µM -0.241895048936187 0.428725707871252 no 1950 0.404430743303788 2777 6462614 SGTC_1708 st033234 31.827 µM -0.24263305275068 0.428439533776221 no 1951 0.404144836898352 2963 674664 SGTC_1213 1315-0166 115 µM -0.243341752778167 0.428164758156624 no 1952 0.40387033110859 2949 768401 SGTC_2803 7707263 71.43 µM -0.243952949289926 0.427927814349943 no 1953 0.403633630055169 2862 2199229 SGTC_1245 0418-0076 17.2 µM -0.244976372765744 0.427531119897874 no 1954 0.403237362916797 3023 6790114 SGTC_664 1222-0054 14.9 µM -0.245229692623553 0.427432940575728 no 1955 0.403139293391759 2861 6813991 SGTC_3006 9075424 71.4286 µM -0.246038270524424 0.427119589670089 no 1956 0.402826303642051 2875 7465181 SGTC_686 1319-0111 510 µM -0.247268719619698 0.426642837890293 no 1957 0.402350132689357 3007 4562600 SGTC_2490 carminic acid 95.39 µM -0.247994133820797 0.426361817904896 no 1958 0.402069472797209 2803 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1915 st067105 30.6 µM -0.248023919449011 0.426350279975409 no 1959 0.402057949933265 2808 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2848 9016370 25.97 µM -0.248966682864578 0.425985118427524 no 1960 0.401693276649052 2926 7894410 SGTC_68 0986-0284 82.829 µM -0.249257228311979 0.425872593930254 no 1961 0.401580907088208 3031 423278 YIL048W NEO1 SGTC_2076 5212012 200 µM -0.250716214125367 0.425307639013257 no 1962 0.401016761965475 2802 604802 SGTC_496 calpeptin 138 µM -0.250889410583677 0.425240583276583 no 1963 0.400949805878406 2913 73364 A calpain inhibitor. SGTC_1613 st002381 52.1 µM -0.250980891745281 0.425205165776746 no 1964 0.400914441314174 2859 551167 SGTC_583 1488-1091 88.9 µM -0.251051480516457 0.425177837308184 no 1965 0.400887153834224 2911 4303273 SGTC_1313 1220-0047 237 µM -0.251491728178929 0.425007403383363 no 1966 0.400716978346138 2898 3528706 SGTC_2753 fluvastatin 17.09 µM -0.252218306969019 0.42472615220676 no 1967 0.400436164241807 2933 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1686 st019653 115.5 µM -0.255551300955736 0.423436477673663 no 1968 0.399148663046333 2985 97252 SGTC_2395 5646831 180.19 µM -0.257389870622843 0.422725408260887 no 1969 0.398438910808739 3040 6808628 SGTC_1921 5740136 50 µM -0.25817040408722 0.422423611820258 no 1970 0.398137698982744 3068 1774243 SGTC_426 0988-0037 14.6 µM -0.260155624370844 0.421656223910963 no 1971 0.3973718662811 3049 5383008 SGTC_1410 3909-8106 77.9 µM -0.260289912385128 0.421604325518273 no 1972 0.397320076628362 2933 1039210 SGTC_770 0389-1121 67.2 µM -0.260485204899689 0.421528853099575 no 1973 0.3972447631485 3052 6753108 SGTC_1795 st049545 62.3 µM -0.26076649442173 0.421420151488016 no 1974 0.39713629213144 2945 5291882 SGTC_1562 morin hydrate 59.1 µM -0.261116720935185 0.421284818214363 no 1975 0.397001248715381 3044 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2364 9055074 200 µM -0.261124164822282 0.421281941875067 no 1976 0.396998378569966 2955 6470630 SGTC_3048 9093155 49.47 µM -0.262137598499527 0.420890387480286 no 1977 0.39660768029288 2944 25236002 SGTC_905 2-aminofluorene 215 µM -0.262947384678707 0.42057757138781 no 1978 0.396295566638634 2874 1539 An established DNA mutagen. YPR165W RHO1 SGTC_951 1171-0579 82.7 µM -0.263366036697976 0.420415867992891 no 1979 0.396134232791181 2813 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1917 st066507 28.5 µM -0.263974400011092 0.420180912984901 no 1980 0.395899822556892 2877 3156428 SGTC_2893 9048488 25.97 µM -0.264346252261666 0.420037314530271 no 1981 0.395756561616989 2907 6467338 SGTC_1261 0712-0010 12.7 µM -0.264688126446684 0.419905302118324 no 1982 0.395624862542692 3041 2840123 SGTC_1326 1431-2094 10.8 µM -0.265470276085277 0.419603314224071 no 1983 0.395323602437766 2825 616278 SGTC_402 epigallocatechin gallate 10 µM -0.266168178234083 0.419333894238778 no 1984 0.395054844686177 2892 65064 An antioxidant. SGTC_2603 homopterocarpin 100 µM -0.266711793524389 0.419124061752017 no 1985 0.394845536418117 3008 101795 A weak amylase inhibitor. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.26756427624954 0.418795054487882 no 1986 0.394517366007172 3119 6710655 SGTC_3306 9127676 59.7925 µM -0.269551095829736 0.418028481940574 no 1987 0.393752813933948 2971 41905287 SGTC_2272 7805186 180 µM -0.269750112313633 0.417951712721686 no 1988 0.393676252506172 3018 2956062 YPR165W RHO1 SGTC_1702 st027038 51 µM -0.2711253438443 0.417421312354969 no 1989 0.393147314892024 2933 5521182 SGTC_2128 5255449 168.493 µM -0.271616344001392 0.417231979373161 no 1990 0.392958515536954 2889 736008 SGTC_2189 6047310 154.431 µM -0.272297553528347 0.416969332162666 no 1991 0.392696618590527 2856 711535 SGTC_194 1486-1323 56.904 µM -0.273890974985669 0.416355117331416 no 1992 0.392084203703051 2933 5178754 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.274577813187848 0.416090425276745 no 1993 0.391820306947794 3020 756377 SGTC_2273 7815444 169.05 µM -0.27503432534039 0.415914516766079 no 1994 0.391644933516816 3078 2824616 SGTC_499 genistein 192 µM -0.275757615275645 0.415635844874814 no 1995 0.391367119986286 2946 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1312 1218-2183 165 µM -0.277912650764369 0.41480579665056 no 1996 0.390539706202398 2892 6744073 SGTC_2114 5491910 81.25 µM -0.27834016796087 0.414641176277861 no 1997 0.390375622148011 3013 2849228 SGTC_1140 3229-1848 2.98 µM -0.278860704305154 0.414440758061423 no 1998 0.390175863062863 3009 2849525 SGTC_570 0987-0065 62.6 µM -0.279957223871195 0.414018646270964 no 1999 0.389755161734631 2832 3104428 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.282428432925976 0.413067704335318 no 2000 0.388807507850169 2858 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1165 k072-0275 30.3 µM -0.282656339862226 0.412980029431693 no 2001 0.388720143811943 3002 6153523 YGL055W OLE1 SGTC_202 3594-0513 34.79 µM -0.283737428513512 0.412564198068522 no 2002 0.388305804593204 2902 708429 SGTC_3140 9094243 49.47 µM -0.285840847151384 0.411755417910977 no 2003 0.387500010619755 2924 19291112 SGTC_2649 anisomycin 9.56 µM -0.286045010057602 0.411676935648607 no 2004 0.387421824039796 2973 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1963 st076565 50.3 µM -0.286324118617472 0.411569649245349 no 2005 0.387314943530916 2932 4914280 SGTC_524 r073-0010 27.8 µM -0.287208515580172 0.411229740030157 no 2006 0.386976333196163 2900 2772106 SGTC_374 0880-0231 82.3 µM -0.287293006288686 0.411197270345763 no 2007 0.386943988613828 2993 6833587 SGTC_800 3448-7362 155 µM -0.287381584900792 0.411163230337789 no 2008 0.386910079950542 2990 15991913 SGTC_2275 7947463 200 µM -0.287385036077822 0.411161904093318 no 2009 0.386908758827421 3043 1225414 SGTC_3070 9117005 49.47 µM -0.288864679618348 0.410593389184061 no 2010 0.386342466795249 2935 8779016 SGTC_3265 9137266 49.47 µM -0.289255898609558 0.410443104708301 no 2011 0.386192779110985 2994 17224265 SGTC_2950 9072895 21.46 µM -0.289499250525291 0.41034962913252 no 2012 0.386099676671872 3050 17332245 SGTC_2029 5175081 200 µM -0.292363998103517 0.409249615512221 no 2013 0.385004165815767 2903 1380876 SGTC_3077 9117319 49.47 µM -0.292640751760472 0.4091433845792 no 2014 0.384898380636228 2895 17154678 SGTC_2512 diallyl trisulfide 49.23 µM -0.293720776476301 0.408728884728254 no 2015 0.384485638451894 2954 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_320 4092-0846 5.34 µM -0.293850993652778 0.408678915905637 no 2016 0.384435883497827 3019 1359356 SGTC_1711 st032263 62.8 µM -0.299394736981479 0.406552977256065 no 2017 0.382319438696464 2975 3958979 SGTC_130 0136-0219 337.655 µM -0.299603736796794 0.406472882533192 no 2018 0.382239716747952 2886 234244 SGTC_418 lividomycin a 100 µM -0.299981249216861 0.40632821886696 no 2019 0.38209572915138 3056 72394 An antibiotic. SGTC_2651 TUB2.036 5 µM -0.300623826029592 0.406082011301652 no 2020 0.381850680441504 3063 15992207 YFL037W TUB2 SGTC_1484 3473-2379 286 µM -0.301246609531737 0.405843423111787 no 2021 0.381613225140552 2969 671917 SGTC_1796 st049173 110.4 µM -0.301515572933725 0.405740394113043 no 2022 0.381510688366935 3040 94134 SGTC_315 k915-0449 187 µM -0.302012300478136 0.405550135053911 no 2023 0.381321343054851 2977 20970215 YNL149C PGA2 SGTC_497 capsazepine 133 µM -0.303162081795258 0.405109825754095 no 2024 0.380883172181157 2947 2733484 A calcium channel blocker. SGTC_2988 9073640 71.4286 µM -0.303797172309074 0.404866668989577 no 2025 0.380641210580234 3153 9102229 SGTC_1472 k841-0093 193 µM -0.304155885516334 0.404729344881052 no 2026 0.380504565924765 3063 X1472 SGTC_855 0428-0020 25 µM -0.304555418956113 0.40457640761088 no 2027 0.380352389163993 2963 6812414 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.304913068950629 0.40443951525551 no 2028 0.380216180933485 2942 4620898 SGTC_2210 7115885 190.385 µM -0.305442049649455 0.40423706665148 no 2029 0.380014749965929 2967 2927039 SGTC_1332 1480-0653 17.5 µM -0.305518583149992 0.404207778290221 no 2030 0.379985609408929 3080 5749438 SGTC_653 0203-0016 55.2 µM -0.306054864281221 0.404002565645256 no 2031 0.379781436501994 2984 295302 SGTC_563 tetrahydrosecaminediol 614 µM -0.308082316822633 0.403226982443534 no 2032 0.379009848192215 3088 334274 A psychoactive constituent of the cannabis plant. SGTC_1808 st050063 61.5 µM -0.308144229945511 0.40320330412359 no 2033 0.378986293460308 3107 4011993 SGTC_893 0958-0369 48.9 µM -0.310078295548225 0.402463810917086 no 2034 0.378250708508397 3081 6819948 SGTC_1899 st063254 59.6 µM -0.310521145393013 0.402294535534326 no 2035 0.378082340979335 2917 3093813 SGTC_118 0083-0097 135.343 µM -0.312456570055827 0.401554952210507 no 2036 0.377346782006825 2983 5207356 SGTC_2773 thioridazine 9.09 µM -0.313281213540282 0.401239938346453 no 2037 0.377033510852774 2957 5452 An antipsychotic. SGTC_1295 1013-0063 9.78 µM -0.313334796288464 0.401219471951832 no 2038 0.377013158273129 3069 6826038 SGTC_2144 5628481 200 µM -0.313636829643412 0.401104112768049 no 2039 0.376898441959348 2966 2818399 SGTC_2643 anethole 100 µM -0.314844777316027 0.400642833263842 no 2040 0.376439755981915 3019 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1626 st003712 1.76 µM -0.314951067648138 0.400602250749837 no 2041 0.376399403397294 3120 24207035 SGTC_2449 5812982 45.77 µM -0.315051372230444 0.400563954627795 no 2042 0.376361324511036 3046 776185 SGTC_1590 st077108 57.8 µM -0.315328483198005 0.400458159092081 no 2043 0.376256130417932 3067 5489485 SGTC_2821 7996764 71.43 µM -0.315681113176522 0.400323542438258 no 2044 0.376122281844633 3192 2987135 SGTC_1814 st052110 31.539 µM -0.316288937749575 0.400091532935734 no 2045 0.375891603453573 3109 674163 SGTC_338 4055-0136 114 µM -0.317052715216114 0.399800045476605 no 2046 0.375601801517285 2954 2900563 SGTC_2928 9011484 9.79 µM -0.317505222517126 0.399627377255336 no 2047 0.375430138666224 3090 2994751 SGTC_84 0443-0269 128.823 µM -0.318643508841723 0.39919311559879 no 2048 0.374998428283268 3055 6150058 SGTC_3174 9107204 49.47 µM -0.321176660024266 0.398227154697511 no 2049 0.374038259265517 3098 3938802 SGTC_1738 st035555 74 µM -0.32188598559865 0.397956780615034 no 2050 0.373769535253421 3093 5331140 SGTC_3151 9099821 49.47 µM -0.323160083124486 0.397471255172916 no 2051 0.373287004702647 3089 17174189 SGTC_1729 st035615 45.989 µM -0.325790381362276 0.396469420006489 no 2052 0.372291478307268 3082 17385451 SGTC_2732 terfenadine 20 µM -0.325863727093878 0.396441493644372 no 2053 0.372263730296803 2962 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.329889645687973 0.394909445200917 no 2054 0.370741673752159 3001 115019 SGTC_1732 st034308 51.822 µM -0.331322767038854 0.394364466755858 no 2055 0.370200347979025 2894 830119 SGTC_628 1636-0253 16 µM -0.331616480445078 0.394252800743971 no 2056 0.37008943677793 3079 4456143 SGTC_1614 st002383 48.6 µM -0.333059908505571 0.393704154663723 no 2057 0.36954453082692 3071 1947235 SGTC_2783 7738165 71.43 µM -0.335600848598878 0.39273885808162 no 2058 0.368585941997301 3051 17201110 SGTC_1791 st048313 56.1 µM -0.336488476654087 0.392401805567438 no 2059 0.368251269903318 3104 1204976 SGTC_3263 9137018 49.47 µM -0.336492955517373 0.392400105045826 no 2060 0.368249581441834 3047 43844957 SGTC_2094 5332512 191.667 µM -0.336541295559153 0.392381751571995 no 2061 0.368231358163277 3145 755774 SGTC_1752 st044819 83.042 µM -0.337014303762288 0.392202175127454 no 2062 0.368053058694324 3014 441209 YML126C ERG13 SGTC_3350 9150499 3.57 µM -0.337521351239507 0.392009701246352 no 2063 0.367861959753978 2964 4910996 YPR165W RHO1 SGTC_1482 3346-2049 8.48 µM -0.338068755297142 0.391801937775943 no 2064 0.367655687706603 3078 3826804 SGTC_860 0443-0016 25.1 µM -0.340223124250073 0.390984561934817 no 2065 0.366844252579497 3004 5337942 SGTC_259 usnic acid 108.925 µM -0.341155705461914 0.390630886109081 no 2066 0.366493183492117 3213 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2286 7945697 125 µM -0.341264648493618 0.390589576014166 no 2067 0.366452179297279 3058 1245733 SGTC_1362 1611-0397 101 µM -0.342567781004597 0.390095537215552 no 2068 0.365961821989877 3025 27816 SGTC_2165 5727197 32.143 µM -0.342795459814481 0.390009238652629 no 2069 0.365876170893479 3366 1361712 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.343641812313022 0.389688487786013 no 2070 0.365557837938852 3023 688669 SGTC_1784 st039334 36.3 µM -0.3438133597371 0.389623483852172 no 2071 0.365493326220148 3246 3496984 SGTC_2098 5376439 882.5 nM -0.344002142143163 0.38955195268867 no 2072 0.365422337552333 3106 2844116 SGTC_2184 6075246 200 µM -0.345350238908712 0.389041256936897 no 2073 0.364915541005205 3060 2267320 SGTC_1182 1222-0449 220 µM -0.345450844539677 0.389003152459126 no 2074 0.364877729291946 3084 658318 SGTC_110 0850-0284 111.64 µM -0.34620327859896 0.388718201223283 no 2075 0.364594975470074 2928 3906265 SGTC_2231 micatex 6.853 µM -0.346350886583552 0.38866230822413 no 2076 0.364539515163729 3069 20737 An antifungal of unknown mechanism. SGTC_3083 9117465 49.47 µM -0.347505684892658 0.388225113813501 no 2077 0.364105724193026 3101 16420915 SGTC_2621 lithochol-11-enic acid 100 µM -0.348435639967515 0.387873145570303 no 2078 0.363756520317381 3131 6708711 SGTC_902 1120-0002 2.07 µM -0.348844755639308 0.387718333132549 no 2079 0.363602930672994 3014 3280475 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.349163856777973 0.387597595257186 no 2080 0.363483149375171 3201 23847180 SGTC_818 4072-2707 53.5 µM -0.349829954886337 0.387345599634277 no 2081 0.363233158510339 2955 882871 SGTC_2406 ethylparaben 405.7 µM -0.351176113538229 0.386836471154635 no 2082 0.362728114495038 2911 8434 A possible steroid mimic. SGTC_593 1203-0218 61.7 µM -0.352270137437527 0.38642284550065 no 2083 0.362317840723168 3165 3666956 SGTC_3248 9135562 49.47 µM -0.354771145428674 0.3854777563366 no 2084 0.36138052334445 3076 17650701 SGTC_185 k048-0037 25.491 µM -0.356006467808749 0.385011199015839 no 2085 0.360917860745344 3159 6827589 SGTC_1826 st055655 41.6 µM -0.360721561894777 0.383231934687124 no 2086 0.359153802199378 3111 676168 SGTC_73 0327-0325 16.231 µM -0.361467789075012 0.382950566672573 no 2087 0.358874890051723 3144 53298 SGTC_1438 4092-1045 4 µM -0.361925809216048 0.382777898875257 no 2088 0.358703736292171 3042 1351342 SGTC_940 3232-1287 54.8 µM -0.36236344760221 0.382612936504174 no 2089 0.358540225325762 3121 1585493 YIL048W NEO1 SGTC_3020 9089140 49.47 µM -0.363524013654265 0.382175578693595 no 2090 0.35810673889972 3135 17217859 SGTC_1133 3473-0247 50 µM -0.363567012476968 0.382159377527025 no 2091 0.358090681793078 3075 711311 SGTC_1285 0929-0069 65.5 µM -0.363729120213554 0.382098300164972 no 2092 0.358030147946111 3077 1206237 SGTC_1360 1598-0022 39.8 µM -0.364010470808847 0.381992302614637 no 2093 0.357925095216422 3151 761525 SGTC_1206 3978-0017 132 µM -0.364626127080248 0.381760387794045 no 2094 0.357695254542122 3286 3873677 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.364712927920894 0.381727693736917 no 2095 0.357662853653765 3233 5393153 SGTC_1944 st076371 56.9 µM -0.366334320393194 0.381117141843331 no 2096 0.357057811445206 3018 24208455 SGTC_133 0724-0033 378.92 µM -0.366932604304581 0.38089192656241 no 2097 0.356834645238473 2960 280309 SGTC_1149 3909-7961 23.3 µM -0.369223697838116 0.38002985141503 no 2098 0.355980496775256 3082 735261 SGTC_2388 9080168 200 µM -0.369657524624712 0.379866681343859 no 2099 0.355818841906535 3033 15943073 SGTC_1929 genistein trimethyl ether 50.5 µM -0.371030523404391 0.379350412831581 no 2100 0.355307398688816 3238 136420 SGTC_2533 agelasine 13.65 µM -0.37124368732144 0.379270279207352 no 2101 0.355228018285907 3260 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_587 k089-0003 57 µM -0.37346396054441 0.378435932193654 no 2102 0.354401581735351 3112 9659696 SGTC_2952 9073731 13.78 µM -0.373843285949149 0.378293443661373 no 2103 0.354260456545044 3083 16457353 SGTC_1021 4476-0760 85.3 µM -0.37478980820751 0.37793796739887 no 2104 0.353908397295904 3068 746768 SGTC_1327 1436-0082 2.18 µM -0.375166498158902 0.377796526302609 no 2105 0.353768322071845 3090 15992205 SGTC_1474 0330-0125 5.35 µM -0.375230723020649 0.377772412520872 no 2106 0.353744441508992 3117 X1474 SGTC_2402 5553605 200 µM -0.375535989722083 0.377657804002323 no 2107 0.35363094285738 3251 6758546 SGTC_2198 6589944 200 µM -0.376243805693269 0.377392104910402 no 2108 0.353367825811782 3104 5290268 SGTC_1442 4112-3290 3 µM -0.37710712642141 0.377068111186307 no 2109 0.353046997700097 3057 704353 SGTC_105 0111-0055 734.78 µM -0.37763520380795 0.376869972830891 no 2110 0.352850804517938 3148 5179370 SGTC_3056 9094900 49.47 µM -0.377982109897061 0.376739828865396 no 2111 0.352721942026413 3088 25236784 SGTC_2111 5486399 200 µM -0.378432928763473 0.376570722308071 no 2112 0.352554505115685 3081 689674 SGTC_2784 7567673 72.73 µM -0.378570401560006 0.376519159630999 no 2113 0.35250345255187 3136 3471247 SGTC_2986 9022445 71.43 µM -0.3792487588492 0.376264756710397 no 2114 0.352251573419313 3218 6459286 SGTC_470 aa-861 153 µM -0.381745357099133 0.375328926377944 no 2115 0.351325126619607 3087 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3082 9117008 49.47 µM -0.382408744407856 0.375080383907445 no 2116 0.351079102639706 3108 41448529 SGTC_825 1988-2224 89.6 µM -0.383169184929744 0.37479554360552 no 2117 0.350797162254133 3076 1180859 SGTC_160 3453-0671 289.699 µM -0.383870088594439 0.374533064662548 no 2118 0.35053736845256 3073 5322268 SGTC_83 0170-0301 39.027 µM -0.384077956344014 0.374455232172167 no 2119 0.350460334559207 3119 3089716 SGTC_2903 5923464 63.88 µM -0.384483559152316 0.374303375934278 no 2120 0.350310039565634 3173 2876576 SGTC_1716 st033144 30.6155 µM -0.385073741474012 0.374082448621162 no 2121 0.350091391012941 3246 674617 SGTC_305 1682-2595 20.8 µM -0.385663374086436 0.373861768377165 no 2122 0.349872995730316 3146 226033 SGTC_1386 3228-0095 33.8 µM -0.386295949374422 0.373625062059098 no 2123 0.349638750033973 3199 870181 SGTC_2697 mebhydrolin 72.4 µM -0.387929044185161 0.373014187209269 no 2124 0.349034271910305 3254 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3225 9130819 49.47 µM -0.387932456926237 0.373012910974208 no 2125 0.349033009109473 3207 4547121 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.388821295432051 0.372680566741025 no 2126 0.348704173256006 3175 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1583 clindamycin 39.6 µM -0.38998868376761 0.37224421436059 no 2127 0.348272457397644 3094 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1937 st074714 47.2 µM -0.390197094045554 0.372166330936288 no 2128 0.348195405140083 3058 17250970 SGTC_1518 st038567 90.8 µM -0.390361686179574 0.372104826153604 no 2129 0.348134557504433 3165 77966 SGTC_1328 1441-0025 69.2 µM -0.391835033959808 0.371554411109093 no 2130 0.347590053705917 3071 4562601 SGTC_1276 0871-0068 94.2 µM -0.392954194300975 0.371136489204141 no 2131 0.347176656601139 3168 3414906 SGTC_2267 7931562 200 µM -0.393787203850874 0.370825521609994 no 2132 0.346869076269117 3036 934880 SGTC_1228 0124-0032 52.5 µM -0.393796572338943 0.370822024775011 no 2133 0.346865617623177 3173 X1228 SGTC_2264 7948757 110.76 µM -0.394393472949938 0.370599250646126 no 2134 0.346645280967539 3031 2971411 SGTC_3281 9140613 49.47 µM -0.395341034856457 0.37024569248402 no 2135 0.346295609645763 3136 16013766 SGTC_1624 st003710 6.25 µM -0.395407649137015 0.370220841211957 no 2136 0.346271032425488 3205 24207033 SGTC_3330 9141424 71.43 µM -0.395501096127498 0.37018598058232 no 2137 0.346236556415659 3227 27261020 SGTC_2471 5466956 24.79 µM -0.397763629112803 0.369342263170921 no 2138 0.345402214802893 3079 724419 SGTC_246 cycloheximide 667 µM -0.397850063365486 0.36931004356441 no 2139 0.34537035578866 3069 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3193 9111931 49.47 µM -0.398190658144423 0.369183090916508 no 2140 0.345244825785622 3083 17087244 SGTC_1539 benzyladenosine 56 µM -0.398398661441866 0.369105567180367 no 2141 0.34516817222326 3094 92208 A nucleotide analog. SGTC_2470 5664817 21.68 µM -0.398540714394705 0.369052626484547 no 2142 0.345115826391301 3148 2859561 SGTC_3319 9138450 16.7555 µM -0.398660310843066 0.369008056868208 no 2143 0.345071757971261 3088 2029690 SGTC_303 1348-1668 34.2 µM -0.398719026825304 0.368986176020157 no 2144 0.345050123310353 3135 5380509 SGTC_2140 5586273 200 µM -0.399705719312515 0.36861854296495 no 2145 0.344686639556952 3179 854421 SGTC_2722 naftopidil 47.16 µM -0.400007354832373 0.368506180165417 no 2146 0.34457554982851 3217 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2006 4011487 200 µM -0.400375855693289 0.368368924493678 no 2147 0.344439852368432 3274 45595294 SGTC_1139 k015-0024 46.9 µM -0.401298435589965 0.368025364468356 no 2148 0.344100207621502 3232 2766652 SGTC_347 4534-1311 26.2 µM -0.402676024212357 0.367512560011161 no 2149 0.34359328700893 3105 2862016 SGTC_1964 st076914 61 µM -0.403002383209376 0.367391108129336 no 2150 0.343473235637747 3144 24208661 SGTC_1148 3909-7663 27.7 µM -0.403476795759504 0.367214582963761 no 2151 0.343298750829734 3221 4084526 SGTC_597 k018-0003 82.8 µM -0.40620353217816 0.366200531089067 no 2152 0.342296529494591 3247 6786234 SGTC_2056 5235370 200 µM -0.406323578252973 0.366155908303301 no 2153 0.342252431599365 3108 5511916 SGTC_2147 5545932 89.7195 µM -0.406655906262862 0.366032386830061 no 2154 0.342130364978244 3166 797404 SGTC_2493 resveratrol 26.09 µM -0.406751109350413 0.365997003788995 no 2155 0.342095399194766 3067 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1802 st050112 57.9 µM -0.406911043961508 0.365937565289527 no 2156 0.342036662141754 3149 4662563 SGTC_220 paclitaxel 373.376 µM -0.407367141774956 0.365768077631488 no 2157 0.341869178174503 3205 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_991 3996-0057 64.7 µM -0.409174837587053 0.36509658905866 no 2158 0.341205679381853 3184 715343 SGTC_2328 6201408 200 µM -0.409556406245455 0.364954903944094 no 2159 0.341065690618213 3221 2890418 SGTC_2850 9015429 58.44 µM -0.409591171046521 0.364941995899539 no 2160 0.341052937299437 3169 6457570 SGTC_1043 0916-0009 19.3 µM -0.409920015520523 0.364819904712304 no 2161 0.340932311093679 3298 3101130 SGTC_2718 lomofungin 53.02 µM -0.410147797169254 0.364735343492604 no 2162 0.3408487661235 3265 5351222 A RNA synthesis inhibitor. SGTC_3308 9128332 17.569 µM -0.4105588046597 0.364582778515923 no 2163 0.340698037958236 3259 17332805 YDL196W YDL196W SGTC_2656 pseudo-anisatin 100 µM -0.413341920217352 0.36355025821831 no 2164 0.339678060372135 3142 6708809 A neurotoxin. SGTC_1912 st060209 90.8 µM -0.41458517881363 0.363089335796678 no 2165 0.339222799948344 3171 688787 SGTC_413 propylparaben 100 µM -0.416272693601523 0.362464028222996 no 2166 0.338605235795715 3121 7175 A pharmaceutical preservative. SGTC_129 0088-0017 176.636 µM -0.417028984240103 0.362183904094766 no 2167 0.338328603760275 3245 182446 SGTC_291 SEC14.278 35.5 µM -0.417382661428351 0.362052930148736 no 2168 0.338199267495992 3244 1068044 SGTC_895 0964-0006 13.7 µM -0.41912568489612 0.361407688873046 no 2169 0.337562140121775 3262 6738897 SGTC_1131 3454-3128 32.3 µM -0.419831336872454 0.361146578977707 no 2170 0.3373043353748 3277 710982 SGTC_1155 4088-0394 48.2 µM -0.419987141742657 0.361088935767994 no 2171 0.337247423502374 3121 2326248 SGTC_1052 3253-3998 198 µM -0.421149369092731 0.360659045511947 no 2172 0.336823006629007 3092 5450317 SGTC_2845 9003024 42.97 µM -0.422851813327312 0.360029655122608 no 2173 0.336201690882924 3342 2990173 SGTC_225 nsc-122657 1.016 µM -0.422948194249505 0.359994034607161 no 2174 0.336166529530415 3236 275685 SGTC_1695 st026914 34.495 µM -0.423069811035649 0.359949089141843 no 2175 0.336122163763258 3131 3289191 SGTC_268 camptothecin 39.6153 µM -0.425232735308421 0.359150069195174 no 2176 0.335333511438472 3248 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3208 9114115 49.47 µM -0.42736812788228 0.358361823813479 no 2177 0.334555609038468 3211 650895 SGTC_3087 9117406 49.47 µM -0.42793982007982 0.358150895170241 no 2178 0.334347467520064 3251 42546093 SGTC_407 eburnamonine 100 µM -0.430772231253041 0.357106502772652 no 2179 0.333316996241775 3122 3195 SGTC_1238 0333-0287 48.8 µM -0.431478938067187 0.356846085863199 no 2180 0.333060081906171 3193 7226 SGTC_2104 5389443 200 µM -0.433584077965618 0.356070751039595 no 2181 0.332295249473214 3323 2244536 SGTC_1611 st001856 99.4 µM -0.434025336474051 0.35590830835415 no 2182 0.332135021266849 3201 647478 SGTC_229 benomyl 22.8748 µM -0.434492968307448 0.355736185273919 no 2183 0.33196524996311 3239 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_589 1227-0070 34.1 µM -0.436316557191169 0.355065251007416 no 2184 0.331303535291534 3286 2841384 SGTC_2481 5478948 45.16 µM -0.436939308920625 0.35483623115342 no 2185 0.331077681599552 3299 77792 SGTC_2245 6637752 200 µM -0.437353165071129 0.35468406262718 no 2186 0.330927622157543 3251 681890 SGTC_2302 7771753 200 µM -0.43747352380735 0.354639812926215 no 2187 0.330883986571937 3225 2203047 SGTC_2499 avocadenofuran 51.48 µM -0.438915201607553 0.354109934951508 no 2188 0.330361490691007 3137 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2931 9014674 55.67 µM -0.440085300453662 0.353680081338327 no 2189 0.329937663970557 3128 2996810 SGTC_621 3584-0052 32.1 µM -0.440438599971324 0.353550328017105 no 2190 0.329809736641708 3300 2273927 SGTC_2592 piperlongumine 83.33 µM -0.440620347902295 0.353483585621056 no 2191 0.329743934716959 3207 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1017 4239-0030 168 µM -0.4409869412761 0.353348977053438 no 2192 0.329611225446888 3197 1149593 SGTC_1391 3442-0225 151 µM -0.441248537035912 0.353252933528751 no 2193 0.329516539135239 3139 5227075 SGTC_1707 st032323 6.317 µM -0.44144237802178 0.353181771845265 no 2194 0.329446384160373 3215 3132057 YMR211W DML1 SGTC_2127 5253358 187.912 µM -0.441796939109202 0.353051620893363 no 2195 0.329318076862382 3115 20612 SGTC_45 0kpi-0036 14.9 µM -0.442140918856931 0.352925370527145 no 2196 0.329193617907922 3299 2795021 SGTC_2905 7799065 20.05 µM -0.443109856662857 0.352569829830129 no 2197 0.328843138047781 3320 1296806 SGTC_274 sirtinol 40.1 µM -0.443614262023229 0.352384794965132 no 2198 0.328660746318692 3209 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1960 st011366 51.8 µM -0.444023259127539 0.352234785080985 no 2199 0.328512883936495 3200 3972846 SGTC_2100 5377183 190 µM -0.444133734827993 0.352194269305952 no 2200 0.328472948893778 3240 2844202 SGTC_754 3474-0146 171 µM -0.446599030469363 0.351290585812253 no 2201 0.327582297880141 3152 24762078 SGTC_1428 4049-0204 61.7 µM -0.446687404709628 0.35125820674897 no 2202 0.327550388599008 3299 X1428 SGTC_3343 9148379 18.9835 µM -0.446724816684427 0.351244499859347 no 2203 0.327536880639201 3334 1955036 SGTC_399 oxolinic acid 75 µM -0.447174034766358 0.351079931770469 no 2204 0.327374703686266 3179 4628 A DNA gyrase inhibitor. SGTC_1688 st021091 57.6 µM -0.448131441773226 0.350729285226087 no 2205 0.327029168823011 3301 3656366 SGTC_111 0083-0039 52.457 µM -0.448634258114632 0.350545181613134 no 2206 0.326847758245698 3129 759313 SGTC_1547 harmine 94.2 µM -0.448813335779565 0.350479621722802 no 2207 0.326783158883554 3235 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_513 4245-1575 41.7 µM -0.448973024478294 0.350421163841498 no 2208 0.326725558155385 3224 719745 SGTC_2589 lobaric acid 100 µM -0.449328180928972 0.350291163000996 no 2209 0.326597465774511 3174 73157 A novel microtubule depolymerizer. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.449351364249275 0.350282677628949 no 2210 0.326589105080672 3366 94937 An inhibitor of serotonin biosynthesis. SGTC_1931 st074438 57.1 µM -0.449510020725828 0.350224609470031 no 2211 0.326531890496589 3248 2787313 SGTC_1786 berberine 21.6 µM -0.449674389068055 0.350164454464846 no 2212 0.326472620406896 3248 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3338 9144300 39.5675 µM -0.450355525794446 0.349915214284763 no 2213 0.326227053908597 3225 4901274 SGTC_1047 2043-3044 82 µM -0.450402881611596 0.349897888342004 no 2214 0.326209983774039 3205 669592 SGTC_976 1348-1067 47.6 µM -0.450832144199984 0.349740849478185 no 2215 0.326055266066458 3208 5310671 YGL099W LSG1 SGTC_341 1486-1430 230 µM -0.454624328961784 0.3483546584992 no 2216 0.324689764417353 3142 2054753 YPL210C SRP72 SGTC_252 miconazole 1.30953 nM -0.455236895079629 0.348130931073813 no 2217 0.324469409962641 3260 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1184 1269-1718 139 µM -0.456433728615577 0.347693964301351 no 2218 0.324039058111775 3339 5403821 SGTC_1233 0325-0408 14.2 µM -0.457227607290611 0.347404228842227 no 2219 0.323753728523047 3317 12874 SGTC_1022 4477-0945 21.3 µM -0.457334243489698 0.347365317481007 no 2220 0.323715410070235 3204 4648966 SGTC_2864 9034755 47.6 µM -0.457491186750154 0.347308052087713 no 2221 0.323659017770951 3310 4930451 SGTC_3123 9126162 49.47 µM -0.458155001576063 0.347065878165807 no 2222 0.323420542959246 3166 25239884 SGTC_1952 st077036 64.1 µM -0.458326109507449 0.34700346443205 no 2223 0.323359084358008 3282 2937007 SGTC_1298 1079-1278 263 µM -0.459914911702717 0.346424127574182 no 2224 0.32278864821172 3282 2840950 SGTC_2817 7995342 71.43 µM -0.460667133306338 0.346149964533923 no 2225 0.322518719335816 3131 18879975 SGTC_2103 5378138 10 µM -0.461627174886406 0.345800174227003 no 2226 0.322174351738462 3340 244142 SGTC_2120 5538279 151.968 µM -0.463878910845583 0.344980272863268 no 2227 0.32136725152036 3258 2058197 SGTC_844 0330-0132 15.3 µM -0.463919898626231 0.344965355134614 no 2228 0.321352567877741 3338 2828079 SGTC_1441 4106-0040 13 µM -0.464199751265958 0.344863507664582 no 2229 0.321252319700728 3271 2904180 SGTC_795 0685-0265 78 µM -0.466282435834676 0.344105904597902 no 2230 0.32050667464813 3337 302754 SGTC_3031 9088762 49.47 µM -0.4663632128905 0.3440765334914 no 2231 0.320477769320044 3167 205253 SGTC_483 fpl-64176 144 µM -0.466648246009775 0.343972900958349 no 2232 0.320375781535388 3313 3423 SGTC_977 1348-1378 135 µM -0.467884500212461 0.343523558557955 no 2233 0.319933594138195 3198 X977 SGTC_1436 4092-1007 8.32 µM -0.468444701422313 0.343320014468208 no 2234 0.319733303714372 3224 2881121 SGTC_1364 1653-0028 37.6 µM -0.470974883383838 0.342401262333161 no 2235 0.3188293355756 3277 5718652 SGTC_1288 0973-0013 65.5 µM -0.47440630041122 0.341156745876782 no 2236 0.317605100536147 3348 4315430 SGTC_1531 st059297 52.4 µM -0.475505257159448 0.340758537231221 no 2237 0.317213443507466 3331 7566702 SGTC_2812 7970281 58.44 µM -0.476979136018679 0.340224753526476 no 2238 0.316688489336059 3359 2233435 SGTC_677 0929-0063 136 µM -0.477802944794451 0.339926540201787 no 2239 0.316395232506352 3289 1539583 SGTC_1603 st002045 67.8 µM -0.478867027768934 0.339541497428943 no 2240 0.316016614460905 3352 5887985 SGTC_1449 4112-4002 201 µM -0.478973057888599 0.339503139163019 no 2241 0.315978897779874 3284 2059539 SGTC_2149 5554786 194.827 µM -0.479110861201977 0.339453288868476 no 2242 0.315929881706625 3253 745063 YPR165W RHO1 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.480722031182132 0.338870657383026 no 2243 0.315357035445402 3224 2724 A muscle relaxant with antifungal properties. SGTC_103 0844-0104 51.839 µM -0.481026530322048 0.338760587611159 no 2244 0.315248821559958 3355 5375804 SGTC_1563 conessine 56.1 µM -0.481412598263531 0.338621052298201 no 2245 0.315111642278285 3337 441082 An anti-amoebic, histamine inhibitor. SGTC_1190 1486-1332 13 µM -0.481475784034408 0.338598217373864 no 2246 0.31508919327214 3296 4150046 SGTC_1815 st051655 58.2 µM -0.483107489007845 0.338008735583837 no 2247 0.314509708425486 3329 5984156 SGTC_403 arphamenine a 50 µM -0.484226629331254 0.337604656104604 no 2248 0.314112520069728 3284 5487158 An arginine aminopeptidase inhibitor. SGTC_1107 amlodipine 47 µM -0.484235350849239 0.337601507826837 no 2249 0.314109425604997 3303 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1373 2887-0003 58.5 µM -0.48447703309174 0.337514270330643 no 2250 0.314023680000912 3275 776948 SGTC_3295 9122362 53.5725 µM -0.485498891002552 0.337145517588635 no 2251 0.313661249584032 3334 4730473 SGTC_1369 1866-0067 208 µM -0.486991235713409 0.336607263722682 no 2252 0.31313227094103 3382 3531355 SGTC_1523 st012844 44.7 µM -0.487722258357691 0.336343722954515 no 2253 0.312873291783196 3372 4274103 SGTC_2473 5854593 8.94 µM -0.487805355037028 0.336313770880221 no 2254 0.312843858990745 3172 2872951 SGTC_2023 5144124 124 µM -0.489695927086021 0.335632598025321 no 2255 0.312174542189464 3224 2830192 SGTC_2652 actinonin 100 µM -0.490242970086573 0.335435599097271 no 2256 0.311980988713088 3243 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1218 1348-1416 30.7 µM -0.491306773841651 0.335052635917873 no 2257 0.311604744793376 3290 6787668 SGTC_1660 st012960 28.1 µM -0.493981261125463 0.334090593950471 no 2258 0.310659706783793 3329 24207266 SGTC_595 3909-8003 73.7 µM -0.495045398500412 0.333708114753246 no 2259 0.310284037388852 3373 699517 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.495356823217726 0.33359621310622 no 2260 0.310174133414435 3309 2333 A French combination drug. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.497302652899096 0.332897369873371 no 2261 0.30948782062852 3311 5379071 SGTC_2622 2-methoxyxanthone 59.94 µM -0.49844242806252 0.3324882897239 no 2262 0.309086119162993 3267 71034 A hepatoprotective. SGTC_3022 9087993 49.47 µM -0.499594298544601 0.332075071009285 no 2263 0.308680386625442 3370 17173644 SGTC_1511 0906-3109 28.5 µM -0.499788390203035 0.332005463205779 no 2264 0.308612043139142 3350 2882180 SGTC_1647 st011722 22.4 µM -0.502535589800291 0.331020847637373 no 2265 0.307645412066964 3391 2854783 SGTC_2733 amorolfine 100 µM -0.503245367911255 0.33076664770733 no 2266 0.307395885738215 3343 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1661 st013063 9.66 µM -0.503658003268127 0.330618902338481 no 2267 0.307250862506043 3313 721395 SGTC_1750 st081859 2.357 µM -0.503957936208559 0.330511526979731 no 2268 0.307145468143687 3403 5291695 SGTC_721 1187-1332 279 µM -0.504959102488393 0.33015321260683 no 2269 0.306793780601895 3282 25730 SGTC_2496 diffractaic acid 79.83 µM -0.507335781505182 0.329303230493693 no 2270 0.305959618211304 3481 94870 An apoptosis inducer which activates caspases. SGTC_2544 sphondin 68.51 µM -0.509474230697251 0.328539200649984 no 2271 0.305209928300256 3433 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_122 0236-0016 402.397 µM -0.50996355049444 0.328364475985169 no 2272 0.305038498981967 3383 6808838 SGTC_760 0568-0725 82.9 µM -0.510164820283336 0.328292618139077 no 2273 0.304967998117596 3413 3916171 SGTC_2943 9068529 45.32 µM -0.51100611882915 0.327992324412987 no 2274 0.304673386107641 3390 3270634 SGTC_2596 sinensetin 100 µM -0.511628815373918 0.327770130220836 no 2275 0.304455407268078 3287 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3182 9108849 49.47 µM -0.512336839100445 0.327517563156902 no 2276 0.30420764347405 3400 17133045 SGTC_2033 5192550 145 µM -0.51243072310619 0.327484078666452 no 2277 0.304174796719769 3302 182073 SGTC_2431 5490079 200 µM -0.512673078118161 0.327397647205543 no 2278 0.30409001241992 3340 5722345 SGTC_1046 2001-0062 216 µM -0.513352097335531 0.32715553676514 no 2279 0.303852523748115 3326 739778 SGTC_1813 st051246 8.6015 µM -0.513476446698456 0.327111206750002 no 2280 0.303809041211256 3358 5291959 SGTC_1040 k898-0338 155 µM -0.514295186472023 0.326819390449716 no 2281 0.303522813288381 3445 20969351 SGTC_3001 9076041 71.4286 µM -0.517014365056276 0.325850977919623 no 2282 0.302573065522874 3351 16004211 SGTC_1163 k060-0048 49.9 µM -0.517194504254015 0.325786864248488 no 2283 0.302510194030446 3365 6809982 SGTC_1357 1503-1303 39.5 µM -0.517197311399581 0.325785865192941 no 2284 0.302509214337603 3347 292895 SGTC_1973 st070275 50.2 µM -0.517746800673601 0.325590327538997 no 2285 0.302317470165359 3361 17118334 SGTC_799 1310-0557 151 µM -0.518394276445466 0.325359982635992 no 2286 0.302091603626806 3433 5354492 SGTC_309 k408-0051 1.48 µM -0.518507246994787 0.325319799253068 no 2287 0.302052202554591 3362 3640463 SGTC_1036 k216-0215 33.5 µM -0.518737081022335 0.32523805404981 no 2288 0.301972049786106 3385 622330 SGTC_1942 st076330 65.2 µM -0.518981216976317 0.325151231282271 no 2289 0.30188691980182 3444 24208414 SGTC_2112 5488546 200 µM -0.519453606760628 0.324983260908509 no 2290 0.301722228543628 3292 600757 SGTC_852 0418-0143 439 µM -0.519895546498344 0.324826150036338 no 2291 0.301568189798759 3409 5369229 SGTC_1108 betulinic acid 729.144 nM -0.521306972611541 0.324324592661775 no 2292 0.30107647224664 3342 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_668 1682-0499 62.6 µM -0.522765967248157 0.323806466401852 no 2293 0.300568562769674 3362 682214 SGTC_24 0417-1663 219 µM -0.523600953019825 0.323510095093791 no 2294 0.300278059258172 3392 4329390 SGTC_1897 st060201 15 µM -0.523673863207705 0.323484221535088 no 2295 0.3002526987852 3350 611878 SGTC_2674 ligustilide 100 µM -0.523690804472735 0.323478209729067 no 2296 0.30024680621519 3372 5319022 A signalling regulator. SGTC_1311 1190-0148 100 µM -0.52389462667752 0.323405884648536 no 2297 0.30017591616203 3439 1961333 SGTC_1335 1486-0900 202 µM -0.524365653478585 0.323238769158087 no 2298 0.300012120407397 3399 X1335 SGTC_481 bay k-8644 50 µM -0.524569016582063 0.323166629029828 no 2299 0.29994141503624 3333 2303 A calcium channel antagonist. SGTC_1209 2323-2347 50.3 µM -0.524663141376896 0.323133241867255 no 2300 0.299908692240327 3398 5412760 SGTC_1774 st048371 48.465 µM -0.52557418749302 0.32281015685243 no 2301 0.29959204759473 3279 4242727 SGTC_484 loperamide 105 µM -0.528503103855215 0.321772379672656 no 2302 0.298575096677093 3352 3955 An opioid-receptor agonist. SGTC_375 3970-0961 9.27 µM -0.530643221418365 0.321014968218534 no 2303 0.297833019310971 3340 2898222 SGTC_2560 caryophyllene 100 µM -0.531145271608256 0.32083739470415 no 2304 0.297659057255519 3345 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2164 5685496 200 µM -0.531468835592661 0.320722972891842 no 2305 0.297546965839435 3437 759046 SGTC_2478 5763493 32.33 µM -0.533564907013004 0.319982152834259 no 2306 0.296821296579653 3349 1365576 YLR208W SEC13 SGTC_849 0386-0493 241 µM -0.537298636871174 0.318664308953042 no 2307 0.295530673438035 3340 726119 SGTC_631 k072-0230 41.5 µM -0.537406900761866 0.318626130608217 no 2308 0.295493288827134 3422 5773147 SGTC_1061 3448-9325 110 µM -0.538766911706526 0.318146698375956 no 2309 0.295023848740758 3429 723482 SGTC_598 3937-0236 20.2 µM -0.542708368303868 0.316758975070657 no 2310 0.293665305796576 3424 1379313 SGTC_1470 k295-0292 231 µM -0.543795288139061 0.316376740179947 no 2311 0.293291175810496 3448 5045612 SGTC_369 0957-0393 4.5 µM -0.548204045302524 0.31482833562524 no 2312 0.291775902375657 3395 6997992 SGTC_1256 0570-0116 285 µM -0.548236566616945 0.314816925819718 no 2313 0.291764738486159 3371 410638 SGTC_567 1080-0542 68.4 µM -0.548529033017614 0.314714324603778 no 2314 0.291664349810635 3426 5950415 SGTC_1726 st035556 14.5795 µM -0.549582108228441 0.314345009921094 no 2315 0.291303016670167 3506 5919439 SGTC_2959 9079155 11 µM -0.551333920990016 0.313731058817442 no 2316 0.290702394685561 3464 16189457 SGTC_101 0490-5701 117.494 µM -0.551444141988524 0.313692447306208 no 2317 0.290664623974521 3417 4661669 SGTC_1654 st012436 41.8 µM -0.551910978195893 0.31352893257278 no 2318 0.290504673240127 3427 4323132 SGTC_2676 harmalol 100 µM -0.552229012578366 0.313417558362681 no 2319 0.290395729639608 3459 5459187 A monoamine oxidase inhibitor SGTC_958 1222-0007 33 µM -0.552421847105302 0.313350036862261 no 2320 0.290329682929326 3514 7312461 SGTC_1269 0831-0796 3.05 µM -0.552674670222644 0.313261519682024 no 2321 0.290243100510495 3455 927758 SGTC_2582 agaric acid 100 µM -0.553407491249893 0.313005008801565 no 2322 0.289992205205609 3427 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_510 ag-490 170 µM -0.555983093491059 0.312104183888133 no 2323 0.289111206190894 3528 5328779 SGTC_2795 7780010 54.55 µM -0.556214811436841 0.312023194767131 no 2324 0.289032007535297 3443 953673 SGTC_727 3032-0951 202 µM -0.556483325548199 0.311929356163658 no 2325 0.288940245120351 3396 3652836 SGTC_391 gliotoxin 8.33 µM -0.557049495559133 0.311731534676192 no 2326 0.288746806269666 3510 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2761 levamisole 97.89 µM -0.557910659884871 0.311430745443564 no 2327 0.288452695998884 3504 26879 An alkaline phosphatase inhibitor. SGTC_2514 salinomycin 42.74 µM -0.557968289817469 0.311410620832942 no 2328 0.288433018902608 3482 23682228 A polyether potassium ionophore. SGTC_360 0957-0399 1.01 µM -0.56153261648651 0.310167040387599 no 2329 0.287217250895411 3466 6752301 YPR165W RHO1 SGTC_639 0833-0042 114 µM -0.563382895441013 0.309522338663478 no 2330 0.286587090931216 3388 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3221 9128209 49.47 µM -0.563550352238876 0.309464019749731 no 2331 0.286530091599545 3412 16460723 SGTC_2297 7971671 152.32 µM -0.564228099298935 0.309228034922017 no 2332 0.286299453439695 3507 909016 SGTC_2142 5622915 118.518 µM -0.564385102928985 0.309173379030706 no 2333 0.286246037487987 3430 5322196 SGTC_253 dyclonine 31.25 µM -0.566899038444829 0.30829880703921 no 2334 0.285391388751115 3503 3180 An oral anasthetic. SGTC_1978 st071761 42 µM -0.566928262036965 0.308288646837983 no 2335 0.285381460917821 3384 5147680 SGTC_1396 3511-0007 98.6 µM -0.567298997596114 0.308159765514453 no 2336 0.285255528983368 3436 X1396 SGTC_995 3931-2021 34.6 µM -0.567628505435969 0.308045236313277 no 2337 0.285143623562732 3434 730143 SGTC_2552 juarezic acid 87.02 µM -0.567727793790434 0.308010729672747 no 2338 0.285109907966934 3502 1549512 SGTC_681 1642-0006 26.6 µM -0.568366088798866 0.307788937384487 no 2339 0.284893205917997 3488 4446530 SGTC_688 0527-0193 473 µM -0.569672217702745 0.30733530765421 no 2340 0.284450018375659 3404 4007154 SGTC_2290 7904846 200 µM -0.572267411674564 0.306434849238013 no 2341 0.283570411958575 3456 2962154 SGTC_2492 derrusnin 100 µM -0.572566038864202 0.306331308910875 no 2342 0.283469279922734 3430 1715307 Part of coumarin class of compounds. SGTC_2924 9010168 62.78 µM -0.572659912914999 0.306298763997254 no 2343 0.283437492437852 3455 2993929 SGTC_2989 9073649 71.4286 µM -0.573988356856029 0.305838373674974 no 2344 0.282987840099501 3485 21367202 SGTC_588 3970-1144 52.9 µM -0.575485061678084 0.305320037628821 no 2345 0.282481645364455 3445 1888707 SGTC_3229 9132204 49.47 µM -0.576000360930217 0.30514167036752 no 2346 0.282307468816436 3460 17682924 SGTC_2399 5884133 200 µM -0.576074001944432 0.305116183819245 no 2347 0.282282581602418 3421 722445 SGTC_2563 tomatine 8.54 µM -0.576601355753058 0.304933698633787 no 2348 0.282104391568708 3538 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2000 st075254 36.4 µM -0.578508679870929 0.304274094586092 no 2349 0.28146036948318 3453 17234175 SGTC_1762 st045503 25.4615 µM -0.579322926698671 0.303992699772979 no 2350 0.281185649250806 3463 4645554 SGTC_2712 st079126 47.7 µM -0.583585057706135 0.30252165097467 no 2351 0.279749757816432 3458 3152970 SGTC_2786 7743617 45.45 µM -0.584188692620827 0.302313568254328 no 2352 0.279546684092618 3391 583674 SGTC_1093 fluphenazine 7.97 µM -0.584310649644092 0.302271535493568 no 2353 0.279505664232538 3489 6602611 An atypical antipsychotic. SGTC_275 trichlorophene 5.69 µM -0.584413018820838 0.302236255752357 no 2354 0.279471234939329 3498 62616 SGTC_2180 6301957 200 µM -0.584490154440958 0.302209673534655 no 2355 0.279445293677783 3486 845462 SGTC_2875 9039966 71.43 µM -0.585469658758864 0.301872211357578 no 2356 0.279115981114352 3456 6463691 SGTC_2765 myclobutanil 7.74 µM -0.585558311784046 0.301841676672374 no 2357 0.279086184990587 3503 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_772 k072-0172 35.3 µM -0.58592473108239 0.301715485916199 no 2358 0.278963048527087 3416 5861980 SGTC_1839 st053978 48 µM -0.586268383758146 0.301597157293495 no 2359 0.278847586886338 3532 3788398 SGTC_3078 9116413 49.47 µM -0.587446517845748 0.301191653398464 no 2360 0.278451929844788 3424 17177322 SGTC_2781 5567276 71.43 µM -0.58774487820867 0.301088999247711 no 2361 0.278351773827839 3511 2853274 SGTC_2516 gossypol 71.55 µM -0.587768687259136 0.301080808162487 no 2362 0.278343782169988 3539 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_177 1327-0068 8.361 µM -0.587941232785123 0.301021449909181 no 2363 0.278285869518914 3491 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_390 dec-rvkr-cmk 16.7 µM -0.590369171584199 0.300186762487871 no 2364 0.277471587044597 3475 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_610 4215-0184 155 µM -0.591454042934706 0.299814139251456 no 2365 0.277108119553823 3513 5605015 SGTC_405 ebelactone b 50 µM -0.591645765755661 0.299748309558673 no 2366 0.277043910353397 3456 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2510 benzyl isothiocyanate 8.31 µM -0.592311707455299 0.29951970357719 no 2367 0.276820938806456 3492 2346 DNA damaging agent; causes G2/M arrest. SGTC_1843 st055809 45.5 µM -0.592711753051403 0.299382413021431 no 2368 0.276687037244451 3511 16413835 SGTC_2824 7998404 51.95 µM -0.593565809459486 0.299089407276526 no 2369 0.276401277362835 3457 837851 SGTC_1656 st012921 11 µM -0.593759169371107 0.299023088324968 no 2370 0.276336600911423 3455 6732821 SGTC_51 1013-0126 23.419 µM -0.59453105788915 0.298758411086881 no 2371 0.276078487936694 3621 1627850 SGTC_2342 7990637 118.86 µM -0.596727111895512 0.298005976738185 no 2372 0.275344794170605 3514 2033102 YER133W GLC7 SGTC_2751 anetholtrithion 17.25 µM -0.599815970538059 0.296949104937129 no 2373 0.274314444279807 3491 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2250 alverine citrate 130 µM -0.60041347186851 0.296744864315718 no 2374 0.274115355843716 3475 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2628 lathosterol 100 µM -0.602792163188795 0.295932407655214 no 2375 0.273323480415892 3576 6710616 SGTC_1747 st037496 66.6 µM -0.60321066126305 0.295789572785778 no 2376 0.273184278098045 3501 723305 SGTC_2366 9070441 60.58 µM -0.603559253021199 0.295670621372137 no 2377 0.273068355089604 3487 6837235 SGTC_3110 9122132 49.47 µM -0.604394969978975 0.295385535777344 no 2378 0.272790539579351 3596 918317 SGTC_1608 st001473 40.5 µM -0.604464260535306 0.295361904578065 no 2379 0.272767511771759 3422 7292267 SGTC_573 3702-0553 84.7 µM -0.604933012180216 0.295202062014724 no 2380 0.272611753646173 3518 1222756 SGTC_2832 7992762 51.95 µM -0.605983022994498 0.294844156831944 no 2381 0.272263013361709 3347 2985177 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.606349824990425 0.29471917638674 no 2382 0.272141239616156 3528 16486 A toxic proline analog. SGTC_2696 st077691 74.316 µM -0.607117932205164 0.29445753839108 no 2383 0.271886325222543 3522 757133 SGTC_44 0929-0055 61.211 µM -0.608023361923487 0.29414926240462 no 2384 0.271585989760259 3440 1379590 SGTC_2759 disulfiram 3.38 µM -0.609478100464528 0.293654273164306 no 2385 0.271103792081679 3488 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2281 7943571 200 µM -0.610675245932952 0.293247221962317 no 2386 0.270707298488941 3588 1244024 SGTC_2480 5767542 37.17 µM -0.610784851428978 0.293209967176429 no 2387 0.270671011712491 3535 2867358 SGTC_2427 5545055 42.75 µM -0.610922248294033 0.293163269234826 no 2388 0.270625527558564 3531 5372858 SGTC_2636 apigenin dimethyl ether 100 µM -0.612002506826099 0.292796235141483 no 2389 0.270268049498508 3554 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1958 st076513 41.9 µM -0.612126475155151 0.292754128686419 no 2390 0.270227041131553 3458 732122 YGL099W LSG1 SGTC_3272 9137413 49.47 µM -0.613783219621811 0.292191677333663 no 2391 0.269679293659118 3500 17614870 SGTC_2972 9093619 59.92 µM -0.614957859790863 0.291793201350979 no 2392 0.269291275169731 3480 25236256 SGTC_2889 9059656 51.95 µM -0.616052702798007 0.291422023284492 no 2393 0.268929868324221 3560 3949838 SGTC_23 0213-0011 39.996 µM -0.616124508689968 0.291397687062166 no 2394 0.268906173765901 3578 627608 SGTC_679 0422-0091 41.4 µM -0.616473801164846 0.291279319504786 no 2395 0.268790928944459 3559 627384 YHR062C RPP1 SGTC_933 2914-0560 114 µM -0.61714122343488 0.291053207171398 no 2396 0.268570790060964 3573 463887 SGTC_2085 5307070 144.047 µM -0.619748145439895 0.290170808892806 no 2397 0.267711806422993 3500 2840351 SGTC_740 k014-0057 261 µM -0.619876659093412 0.290127341668967 no 2398 0.267669496869515 3513 4012779 SGTC_2240 6690706 185.951 µM -0.62009533487748 0.290053385886325 no 2399 0.267597511683923 3475 805876 SGTC_2763 lisinopril 49.32 µM -0.621053255463483 0.289729522939256 no 2400 0.267282291908817 3551 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_423 5-fluorouracil 457 µM -0.621862861342647 0.289455936032348 no 2401 0.267016023740855 3523 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1142 3253-1408 9.78 µM -0.622327308617992 0.289299041998069 no 2402 0.266863333949258 3560 256655 SGTC_36 0335-0881 14.2 µM -0.622656758821822 0.289187775297978 no 2403 0.266755051994861 3506 23828853 SGTC_1933 st074711 15.9 µM -0.623772924039991 0.288810957422265 no 2404 0.266388361834163 3551 17250958 SGTC_2679 rapamycin 1 nM -0.625477058507937 0.288236087123612 no 2405 0.26582900040919 3558 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_192 3455-0609 60.9 µM -0.625519620247993 0.288221736317557 no 2406 0.26581503765863 3608 3769639 SGTC_1262 0737-0114 49.6 µM -0.626676285453934 0.287831865427546 no 2407 0.265435725906853 3597 765919 SGTC_7 0192-1582 4.227 µM -0.627114009025968 0.287684389304714 no 2408 0.265292252414452 3596 252616 SGTC_1777 st045864 34.765 µM -0.629072098094741 0.287025115076392 no 2409 0.264650928125608 3570 4691462 SGTC_3154 9100113 49.47 µM -0.631371416881193 0.286251866003564 no 2410 0.263898850322302 3518 25237525 SGTC_3074 9116018 49.47 µM -0.631597929681275 0.286175744470925 no 2411 0.263824819873784 3587 17027303 SGTC_1981 st071826 47 µM -0.633640364679823 0.285489801585693 no 2412 0.263157775966591 3530 11838600 SGTC_978 1416-0512 87.4 µM -0.633813512865245 0.285431686533179 no 2413 0.263101266716647 3590 6814003 SGTC_711 k292-0785 179 µM -0.633822857878985 0.28542855015482 no 2414 0.263098217021505 3596 4146315 SGTC_2373 9071805 200 µM -0.634160656876444 0.285315188899504 no 2415 0.262987990258441 3594 10149009 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.634295490547316 0.285269946340968 no 2416 0.262943999446491 3587 66535 A nucleotide analog. SGTC_3294 9122953 26.2835 µM -0.635281991873927 0.284939036286753 no 2417 0.262622258167936 3583 16459826 SGTC_1504 k297-0033 30 µM -0.636123359599546 0.284656954300857 no 2418 0.262348010576783 3457 4388117 SGTC_474 dl-dihydrosphingosine 5 µM -0.638063770302226 0.284006909342698 no 2419 0.26171608463889 3617 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2487 5918373 44.05 µM -0.639183239349427 0.283632206310745 no 2420 0.261351867133193 3631 2876279 SGTC_590 k048-0076 22.4 µM -0.639691662909375 0.283462107578793 no 2421 0.261186538334061 3588 6832814 SGTC_1199 1638-0010 4.46 µM -0.640047072502111 0.283343230407785 no 2422 0.261070998429242 3537 3111136 SGTC_2865 9030313 51.95 µM -0.640821827580569 0.283084173714576 no 2423 0.260819224831696 3523 42562754 SGTC_1272 0839-0021 27 µM -0.642157297850859 0.28263789637369 no 2424 0.260385527991675 3571 5027250 SGTC_269 exalamide 29 µM -0.643230628984968 0.282279463976106 no 2425 0.260037230848822 3543 3316 A derivative of salicylamide. SGTC_1473 k844-0725 134 µM -0.646714833518601 0.281117444902836 no 2426 0.258908260498214 3654 54682906 SGTC_1045 1348-1485 165 µM -0.647244728240334 0.280940922038967 no 2427 0.258736783627968 3627 6810614 SGTC_2680 butyl paraben 22.24 µM -0.649147790322016 0.280307400498977 no 2428 0.258121427190003 3623 7184 An antifungal and steroid mimetic. SGTC_1992 st073643 23.3 µM -0.649740900757796 0.280110097989673 no 2429 0.257929799745589 3588 3161292 SGTC_657 3534-0529 86.7 µM -0.651137023593977 0.279645933401705 no 2430 0.257479019360822 3626 1049549 SGTC_3256 9138902 49.47 µM -0.652226232918035 0.279284066817692 no 2431 0.257127619673031 3604 17228773 SGTC_613 3914-0030 117 µM -0.652727905057891 0.27911747351195 no 2432 0.256965854603201 3402 1145395 SGTC_2607 solasodine 47.35 µM -0.653325402348267 0.278919122028656 no 2433 0.256773259648766 3602 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2285 7945142 200 µM -0.65502138721966 0.278356478928546 no 2434 0.256226992095971 3610 2970608 SGTC_2319 6033012 152.6 µM -0.656201030483737 0.277965458662548 no 2435 0.255847392972244 3557 847246 SGTC_1768 st044301 37.178 µM -0.657745221424933 0.277454006024631 no 2436 0.255350929477434 3601 3931349 SGTC_1605 st000082 49.1 µM -0.658171186387942 0.277313002840954 no 2437 0.255214068717261 3609 1114022 SGTC_2343 7990716 14.84 µM -0.658459288087627 0.277217655109545 no 2438 0.255121524594764 3595 6456862 SGTC_847 0342-0274 5.54 µM -0.660911771295644 0.276406651684074 no 2439 0.254334448313203 3613 18097 SGTC_2838 9002687 71.43 µM -0.663031907547585 0.275706490039745 no 2440 0.253655059466725 3603 6457060 SGTC_3143 9086658 49.47 µM -0.664511952877361 0.275218231660397 no 2441 0.253181350649829 3664 25236626 SGTC_1404 3909-7820 48.3 µM -0.664734536507739 0.275144839450525 no 2442 0.253110149972259 3595 23741373 SGTC_302 1094-0063 18.9 µM -0.66501886979468 0.275051100628028 no 2443 0.253019211964098 3571 5440289 SGTC_3028 9087778 49.47 µM -0.665632208766749 0.274848948994777 no 2444 0.252823106974518 3577 17217395 SGTC_3000 9075062 71.4286 µM -0.665986796815568 0.274732113017456 no 2445 0.252709769824311 3599 17057871 SGTC_2139 5578692 56.4705 µM -0.666467490544664 0.274573764609009 no 2446 0.252556168185898 3570 650991 YMR113W FOL3 SGTC_1949 st076024 69.1 µM -0.667604478655389 0.274199401342238 no 2447 0.252193049052533 3602 2921930 SGTC_2698 st077697 67.5 µM -0.668934060049685 0.273761945063753 no 2448 0.251768771032321 3575 3154499 SGTC_1522 st012842 45.6 µM -0.669356462026913 0.273623039473882 no 2449 0.251634058760268 3559 3491067 YOR116C RPO31 SGTC_2930 9013230 14.89 µM -0.669934589160662 0.273432980691485 no 2450 0.251449744415911 3605 2995857 SGTC_509 pifithrin 175 µM -0.670234995911291 0.273334248050142 no 2451 0.251353999067923 3658 4817 A p53 inhibitor. SGTC_1051 3253-3903 78 µM -0.671839138887707 0.272807324357652 no 2452 0.25084305457657 3612 5509239 SGTC_2887 9044784 58.44 µM -0.673741524313652 0.272183088785092 no 2453 0.250237828641848 3644 6465546 SGTC_1068 loratadine 26.9 µM -0.674731888090252 0.271858398913421 no 2454 0.249923060533655 3629 3957 A H1 histamine antagonist. SGTC_471 1-acyl-paf 4 µM -0.67481294673742 0.271831832443317 no 2455 0.24989730690616 3590 16759367 SGTC_3009 9080819 71.4286 µM -0.675170540534386 0.271714648710471 no 2456 0.249783710458663 3642 17027216 SGTC_2243 6634756 200 µM -0.67648687226147 0.27128350266166 no 2457 0.249365789065691 3683 885676 SGTC_1049 3226-0134 66 µM -0.67675955032777 0.271194233427097 no 2458 0.249279263161883 3673 5702385 SGTC_1902 st060212 70.5 µM -0.678216907627971 0.270717372837516 no 2459 0.24881708692895 3664 688944 SGTC_2677 mitomycin C 100 µM -0.680008664554466 0.270131668000184 no 2460 0.248249487325159 3648 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1208 2323-2347 50.3 µM -0.681357193743333 0.269691267686083 no 2461 0.247822750883979 3646 5412760 SGTC_3234 9132280 49.47 µM -0.68178668123491 0.269551081956134 no 2462 0.247686923624506 3656 17612295 SGTC_2797 7859098 81.82 µM -0.682559628867261 0.269298882053045 no 2463 0.247442575817944 3677 972681 SGTC_3280 9140961 49.47 µM -0.682596334504635 0.269286908560441 no 2464 0.247430975465666 3639 4901226 SGTC_1075 aripiprazole 15.2 µM -0.683019323579593 0.269148947482982 no 2465 0.247297316095708 3681 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3285 9112818 20.8695 µM -0.683055419430826 0.269137176191238 no 2466 0.247285912036353 3683 17017947 YPR165W RHO1 SGTC_1811 st050069 61.5 µM -0.683405874559789 0.269022901983938 no 2467 0.247175204481478 3633 3877702 SGTC_1345 1488-0192 31.4 µM -0.683501311324471 0.268991786782654 no 2468 0.247145060932442 3662 658348 SGTC_2074 5212007 75.395 µM -0.686056114784388 0.268159517507282 no 2469 0.246338861654214 3582 758611 SGTC_901 1112-0062 60.1 µM -0.687869514250676 0.267569560167145 no 2470 0.245767477955296 3662 1908457 SGTC_981 1488-1094 54.9 µM -0.688905544731042 0.267232799994422 no 2471 0.245441354961605 3636 3449522 SGTC_771 0250-0039 27.3 µM -0.692296226433883 0.266132161580728 no 2472 0.244375659695583 3656 3005115 SGTC_3268 9137683 49.47 µM -0.692548368799741 0.26605040623613 no 2473 0.244296510785325 3675 1953228 SGTC_908 3448-7491 47.7 µM -0.693289040412675 0.265810322392633 no 2474 0.244064089723359 3693 1203031 SGTC_63 0099-0242 26.702 µM -0.693299543880506 0.265806918552271 no 2475 0.244060794616984 3686 3898502 YLR359W ADE13 SGTC_2054 5233173 129 µM -0.694045717557454 0.265565163907357 no 2476 0.243826769375417 3677 6889 SGTC_2601 securinine 100 µM -0.694406799668105 0.26544821608248 no 2477 0.24371356534147 3643 442872 A GABA receptor antagonist. SGTC_2247 cerulenin 830 nM -0.695797149028508 0.264998151773583 no 2478 0.243277937466664 3710 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_422 cantharidin 155 µM -0.696994375592514 0.264610913369433 no 2479 0.242903156835466 3637 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1684 st024538 14.6195 µM -0.69770180715319 0.264382232677627 no 2480 0.242681848886323 3658 6732859 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.697987023041581 0.264290063718695 no 2481 0.242592654826108 3736 688664 SGTC_3197 9113331 49.47 µM -0.698688145830786 0.264063561900944 no 2482 0.242373471869358 3691 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2701 st077767 14.721 µM -0.698929786782991 0.263985521302414 no 2483 0.242297955651768 3677 5721188 SGTC_1505 k297-0037 20.6 µM -0.699581763115587 0.263775017045359 no 2484 0.242094267450407 3676 4089396 SGTC_2837 9008476 45.46 µM -0.700422545968125 0.263503679066866 no 2485 0.241831730097492 3687 2992805 SGTC_2438 5259590 200 µM -0.701922781217505 0.263019876308323 no 2486 0.241363660463819 3705 1201127 SGTC_1307 1187-1599 12.2 µM -0.702989499148692 0.262676152590691 no 2487 0.241031146788579 3675 1538471 SGTC_2655 perillic acid 100 µM -0.703952830308541 0.262365940334035 no 2488 0.240731074669203 3682 5702197 An apoptosis inducer. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.704479841448282 0.262196311438914 no 2489 0.240566999803237 3628 1241132 A phosphatase inhibitor. SGTC_1078 idebenone 36.1 µM -0.704571722319257 0.262166743527703 no 2490 0.240538400680747 3705 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_475 α-linolenic acid 10 µM -0.706385881655758 0.261583284391878 no 2491 0.239974099175853 3758 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1751 st044839 27.194 µM -0.707519853427591 0.261218921942603 no 2492 0.23962173971401 3678 5291326 SGTC_3102 9121669 49.47 µM -0.708352304539221 0.260951608775438 no 2493 0.239363251731953 3714 41905072 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.708476911252088 0.260911607704438 no 2494 0.239324572673886 3710 5282362 SGTC_1374 2889-5571 141 µM -0.709142292598116 0.260698061317552 no 2495 0.239118090050482 3703 2853281 SGTC_2630 antimycin a 100 µM -0.709648916406405 0.260535526648349 no 2496 0.238960938735275 3700 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2725 haloperidol 53.21 µM -0.709703285673336 0.260518087041556 no 2497 0.238944077108576 3654 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2259 7964009 200 µM -0.709844092401011 0.260472924357179 no 2498 0.238900411519965 3691 313134 SGTC_1329 1447-1697 50.6 µM -0.710589716562241 0.260233838313382 no 2499 0.238669258689029 3685 2840515 SGTC_527 4476-4215 268 µM -0.711553672439064 0.25992491141871 no 2500 0.238370601768109 3683 4418754 SGTC_1458 k015-0034 6.33 µM -0.712377743216616 0.259660964711764 no 2501 0.238115447001332 3708 3598957 SGTC_2131 toluylene red 5.2905 µM -0.712745767142128 0.259543132768592 no 2502 0.238001545131406 3699 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2354 9060492 162 µM -0.713489393537766 0.259305126712596 no 2503 0.237771487035923 3735 6471895 SGTC_2113 5491891 107.031 µM -0.716049512581941 0.258486594945291 no 2504 0.236980388377859 3717 789979 SGTC_2913 7966556 36.57 µM -0.717568882511543 0.258001449346554 no 2505 0.236511575027732 3626 2976516 SGTC_1435 4092-0789 56.7 µM -0.718102097791674 0.257831301954001 no 2506 0.23634716839763 3702 2248285 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.72244127832264 0.256448850649068 no 2507 0.235011608037094 3737 229346 A bile salt which induces apoptosis. SGTC_1465 k213-0056 144 µM -0.723429623118686 0.25613450753607 no 2508 0.234707988548503 3621 24048857 YMR208W ERG12 SGTC_3141 9094609 49.47 µM -0.723625825364444 0.256072129314319 no 2509 0.234647741036589 3670 25236309 YDL196W YDL196W SGTC_1553 gossypol 38.6 µM -0.726020176061738 0.255311536613109 no 2510 0.233913200981661 3619 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2513 baicalein 25.65 µM -0.728077881243395 0.254658827970162 no 2511 0.233282956449763 3711 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_619 1652-1634 108 µM -0.728491371591773 0.25452777344175 no 2512 0.233156424304604 3690 5400454 SGTC_147 4466-0538 29.23 µM -0.730142044360363 0.254004949935388 no 2513 0.232651681901779 3781 6742687 YHR072W ERG7 SGTC_2929 9013348 24.6 µM -0.73272829702259 0.253186931287435 no 2514 0.231862080793925 3756 2995952 SGTC_2159 5658611 73.75 µM -0.733219308355198 0.253031783517877 no 2515 0.231712340357309 3719 793844 SGTC_1478 0453-0656 35.7 µM -0.734996112262438 0.252470774497783 no 2516 0.231170930917698 3758 5258496 SGTC_2261 9010538 184.68 µM -0.735131498640751 0.252428054420894 no 2517 0.231129706331963 3671 6457250 SGTC_1984 st072354 53.1 µM -0.736802865674919 0.251900982045164 no 2518 0.230621120131244 3667 5762938 SGTC_66 0109-0187 42.4 µM -0.740029020021842 0.250885246249403 no 2519 0.229641192895686 3729 759417 SGTC_224 benfluorex 43.875 µM -0.740235501367162 0.250820310705327 no 2520 0.229578554799691 3717 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1126 isoteolin 1.0172 µM -0.740466179453646 0.250747776143275 no 2521 0.229508587711979 3715 133323 SGTC_1515 3460-0031 42.1 µM -0.740947102273369 0.250596590195416 no 2522 0.229362757196019 3690 2876596 SGTC_172 1112-0046 2.638 µM -0.741660418479061 0.250372436549577 no 2523 0.229146553579436 3706 2802135 YIL048W NEO1 SGTC_701 4424-0219 185 µM -0.742979036140239 0.249958351980887 no 2524 0.228747186342876 3752 2911779 SGTC_2880 9042983 58.44 µM -0.744575943765306 0.249457363217582 no 2525 0.228264057561706 3749 6464714 SGTC_76 0433-0009 400.328 µM -0.745399996360635 0.24919904676168 no 2526 0.228014973042461 3821 2841569 SGTC_1844 rapamycin 4 nM -0.747178878412864 0.248641904472789 no 2527 0.227477795944431 3698 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1928 4'-methoxychalcone 40.3 µM -0.747949034823318 0.24840089899351 no 2528 0.227245449594522 3791 641818 SGTC_853 0419-0306 21 µM -0.748299232042417 0.248291352774212 no 2529 0.227139843816705 3757 762713 SGTC_3113 9123498 49.47 µM -0.750526014082626 0.247595389570355 no 2530 0.226468981095679 3778 8897275 SGTC_4 0960-0234 25.671 µM -0.750614276501252 0.247567825333012 no 2531 0.226442413344939 3726 6821112 SGTC_1865 st057639 52.2 µM -0.750858100699937 0.24749168787654 no 2532 0.226369029301387 3749 688818 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.75133386171827 0.247343160993232 no 2533 0.226225877653653 3766 5377381 SGTC_1322 1348-1070 12 µM -0.751763503212987 0.247209073025973 no 2534 0.226096646863076 3722 6758089 SGTC_2323 6148992 148.28 µM -0.751820979111966 0.247191138166716 no 2535 0.226079361995856 3749 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1799 st045822 46.1415 µM -0.752506066498427 0.24697741613597 no 2536 0.22587339151177 3742 3674992 SGTC_2091 4-phenylthiadiazole 200 µM -0.752739958694834 0.246904473032959 no 2537 0.225803096483384 3762 270010 SGTC_211 3455-0679 143.504 µM -0.755072608472448 0.246177629413178 no 2538 0.225102708691031 3774 748649 SGTC_1588 farnesol 29.9 µM -0.75847390327651 0.245119860346357 no 2539 0.224083665066675 3777 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1044 1222-0021 1.78 µM -0.75967165005412 0.244747955717877 no 2540 0.22372543941968 3784 4306703 SGTC_3247 9135149 49.47 µM -0.759776864155454 0.2447153008865 no 2541 0.223693987238721 3749 8934436 YOR116C RPO31 SGTC_3085 9117376 49.47 µM -0.76134007067956 0.244230411899176 no 2542 0.223226986290774 3868 16480349 SGTC_1892 st058411 7.36 µM -0.761960836512547 0.244038001142933 no 2543 0.223041689338875 3746 3934738 SGTC_1413 3910-0535 34.4 µM -0.763356402207879 0.24360573439566 no 2544 0.222625436660243 3784 2876951 SGTC_1682 st012968 530 nM -0.764724506897877 0.243182375193561 no 2545 0.222217804928196 3782 24207270 SGTC_2305 7443522 69.23 µM -0.764876276361731 0.243135434744869 no 2546 0.222172610928352 3721 5415886 SGTC_1488 4013-0813 75.9 µM -0.766369500553912 0.242673860008011 no 2547 0.221728237540273 3743 2910057 SGTC_1836 st055642 81 µM -0.766629214799397 0.242593627465287 no 2548 0.221651000216886 3803 8571 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.767399237767419 0.242355831624992 no 2549 0.221422090794938 3801 364106 SGTC_1027 k015-0025 8.67 µM -0.767517011155934 0.242319472392274 no 2550 0.221387091503316 3766 3598955 SGTC_339 3091-4833 71.4 µM -0.767698471273331 0.242263457453393 no 2551 0.221333172308436 3711 3240077 SGTC_1267 0828-0272 9.49 µM -0.769556110772969 0.241690426427332 no 2552 0.220781624056952 3821 745334 SGTC_3204 9114183 49.47 µM -0.769739973879634 0.241633749724855 no 2553 0.220727076446484 3802 17027248 SGTC_367 0335-0881 7.1 µM -0.769991270234244 0.241556298065616 no 2554 0.220652535554087 3764 23828853 SGTC_2881 9058953 51.95 µM -0.770655860512849 0.241351530713595 no 2555 0.220455470678938 3765 17122249 SGTC_333 3486-0131 40.1 µM -0.770876839068478 0.241283465762474 no 2556 0.220389968281345 3835 6744690 SGTC_3138 9097216 49.47 µM -0.771149877401024 0.241199379971034 no 2557 0.220309049749906 3780 25237486 SGTC_2205 7238770 200 µM -0.77299872102951 0.24063042324651 no 2558 0.219761568779154 3821 279867 SGTC_2386 9075165 157.42 µM -0.774458171856859 0.240181813402355 no 2559 0.219329947266956 3761 16452277 SGTC_2182 6325192 200 µM -0.774787194818712 0.240080740457903 no 2560 0.219232708559658 3707 736248 SGTC_1838 st055369 84.5 µM -0.775015275046851 0.240010689838988 no 2561 0.219165316786612 3779 676036 SGTC_1221 2958-7315 257 µM -0.775894592433496 0.239740728122771 no 2562 0.218905612873522 3810 4562705 SGTC_2940 9060638 45.86 µM -0.776546189793773 0.239540786305557 no 2563 0.21871327968257 3810 4027022 SGTC_1559 coumarin 343 70.1 µM -0.776585437358487 0.239528746147997 no 2564 0.218701698013077 3795 108770 A hepatotoxic, DNA x-linker. SGTC_2947 9072639 7.68 µM -0.778422797720475 0.23896546053982 no 2565 0.218159901594448 3830 16488146 SGTC_2225 6654152 15.4 µM -0.778543070657192 0.238928613344604 no 2566 0.218124462794634 3712 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2792 7535235 81.82 µM -0.778989335325834 0.238791921451697 no 2567 0.217992998503093 3813 1281891 SGTC_438 sphingosine 6.67 µM -0.78028433773067 0.238395501536708 no 2568 0.217611764841523 3771 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2816 7982706 58.44 µM -0.781286701466255 0.238088910358286 no 2569 0.217316944941359 3852 2981853 SGTC_1393 3470-5649 58.2 µM -0.781923406302255 0.237894274886162 no 2570 0.217129794196847 3769 4108395 SGTC_2345 9052315 157.45 µM -0.782033387566563 0.237860663350236 no 2571 0.21709747613104 3845 6469265 SGTC_37 0566-0070 1.56 µM -0.78211868208205 0.237834598160994 no 2572 0.217072414196063 3813 1626686 SGTC_1457 k015-0032 57.3 µM -0.78272935351947 0.237648028564375 no 2573 0.216893030537182 3808 4302660 SGTC_2170 morpholine 200 µM -0.783772266200209 0.237329588323435 no 2574 0.216586874999507 3837 121171 Reacts with secondary amines. SGTC_1806 st050005 60.3 µM -0.784368679941486 0.237147586274289 no 2575 0.216411905296946 3813 5194765 SGTC_2418 pentamidine 31.67 µM -0.784972862450449 0.236963291716185 no 2576 0.21623473991266 3773 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2846 9008642 19.48 µM -0.785357641686167 0.236845963062539 no 2577 0.216121954277396 3870 2992898 SGTC_2049 5262831 67.185 µM -0.786021742022467 0.236643537695724 no 2578 0.21592737482782 3863 763417 SGTC_1204 4049-0315 18.3 µM -0.787731952781976 0.23612268434252 no 2579 0.215426755630455 3920 588402 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.789201576836315 0.235675607878878 no 2580 0.214997100263619 3871 5024745 SGTC_514 4466-0038 2.65 nM -0.789634369414239 0.235544036465228 no 2581 0.214870665095207 3735 5722064 SGTC_2785 7756463 72.73 µM -0.789988992851307 0.235436259130319 no 2582 0.214767098306632 3789 2201551 SGTC_1910 st062352 60.4 µM -0.791838100540169 0.234874718552853 no 2583 0.214227541666439 3772 2245730 SGTC_1378 2093-0007 380 nM -0.79226694598695 0.234744591766159 no 2584 0.214102520325 3891 3618014 SGTC_572 0960-0087 17.7 µM -0.793549440861432 0.234355675666172 no 2585 0.213728887964636 3837 6796365 SGTC_903 1134-0042 114 µM -0.794585550410728 0.234041736417509 no 2586 0.213427313183339 3819 701009 SGTC_2691 st077356 60.2 µM -0.794824684076509 0.233969312463633 no 2587 0.213357745090856 3876 2839272 SGTC_3011 9081274 71.4286 µM -0.794928450164073 0.233937889758876 no 2588 0.213327561866169 3820 6625322 SGTC_1348 1493-0373 93.8 µM -0.795987657667349 0.23361727168394 no 2589 0.213019604620393 3825 3010129 SGTC_2612 dictamnine 15.46 µM -0.797693823176402 0.233101334592166 no 2590 0.212524094598728 3825 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3279 9140807 49.47 µM -0.798699364335784 0.232797559823102 no 2591 0.212232377733281 3868 45595718 SGTC_2688 kanamycin b 96.69 µM -0.798708450150437 0.232794815994547 no 2592 0.212229742921184 3928 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_157 1348-1695 65.819 µM -0.800277965133781 0.232321107332815 no 2593 0.211774883385714 3800 5380510 SGTC_3032 9089427 49.47 µM -0.800497188036831 0.232254984514169 no 2594 0.211711396055358 3809 17173707 SGTC_3171 9103192 49.47 µM -0.801195987626397 0.232044279918548 no 2595 0.211509096848854 3858 13018434 SGTC_1696 st025591 34.7925 µM -0.801202899388104 0.232042196390644 no 2596 0.211507096491686 3833 2787147 SGTC_2618 avocadyne 43.43 µM -0.801272727856462 0.232021147411973 no 2597 0.211486887811335 3767 3015189 SGTC_2721 ifenprodil 61.44 µM -0.80218253868115 0.231746992713976 no 2598 0.21122368771948 3821 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2270 7924575 90.91 µM -0.803582287501527 0.231325556905684 no 2599 0.210819127969548 3871 1262135 SGTC_332 4112-0506 40.9 µM -0.803809298433583 0.231257248852794 no 2600 0.210753559418426 3808 2790355 SGTC_1760 st045453 10.4495 µM -0.804014721969697 0.231195446190735 no 2601 0.210694236359423 3901 3323419 YIL048W NEO1 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.808505140285112 0.229846786849447 no 2602 0.209399924077131 3789 97141 SGTC_480 am 92016 50 µM -0.808612133138598 0.22981470626155 no 2603 0.209369141773282 3783 2129 K+ channel blocker. SGTC_2665 lovastatin 100 µM -0.80965227804018 0.229502961355128 no 2604 0.209070026419066 3868 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2511 berberine 10.47 µM -0.810096903989548 0.22936977352715 no 2605 0.20894224177192 3828 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2019 4016004 108 µM -0.810824653557782 0.229151869461257 no 2606 0.208733187245146 3870 45595336 SGTC_476 mead acid 10 µM -0.811269286533751 0.229018793825049 no 2607 0.208605521939602 3853 5312531 An omega 9 fatty acid. SGTC_562 3772-2733 112 µM -0.81155061995105 0.228934615041004 no 2608 0.208524767825136 3876 2876874 YIL048W NEO1 SGTC_254 nsc-64875 3.808 µM -0.811637768046354 0.22890854266853 no 2609 0.208499756522825 3892 56993 SGTC_1074 carmofur 3.8 µM -0.8120434982842 0.228787181004971 no 2610 0.208383336171731 3880 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1765 st044815 90.4 µM -0.812859703189062 0.228543147981434 no 2611 0.208149250284391 3898 645695 SGTC_837 0091-0265 12.5 µM -0.81508524231079 0.227878488587179 no 2612 0.207511759213106 3829 759367 SGTC_1940 st075990 51.1 µM -0.815749170899822 0.227680416507088 no 2613 0.207321804926333 3930 1084979 SGTC_1697 st025554 27.742 µM -0.817134818934451 0.227267343776945 no 2614 0.206925693370266 3820 1269519 SGTC_3112 9123419 49.47 µM -0.818914664953979 0.226737377644225 no 2615 0.206417551176413 3891 17015854 SGTC_174 3553-0389 74.3 µM -0.819124136192832 0.226675051482264 no 2616 0.206357796256912 3875 738071 SGTC_3159 9100096 49.47 µM -0.820261776738409 0.226336726329616 no 2617 0.206033445706247 3815 25236875 SGTC_2146 5545642 200 µM -0.822772728550923 0.225590999883503 no 2618 0.205318623927158 3843 825326 SGTC_1724 st037281 8.293 µM -0.824137768045029 0.225186181520093 no 2619 0.204930641204485 3864 574124 YDL195W SEC31 SGTC_1437 4092-1038 11.6 µM -0.824359189741261 0.225120555146838 no 2620 0.204867748026497 3871 3977136 SGTC_79 0052-0007 94.094 µM -0.824426874950564 0.225100496335838 no 2621 0.204848524839379 3861 2801472 SGTC_508 roscovitine 141 µM -0.824782394646677 0.2249951531324 no 2622 0.204747571773464 3915 160355 A CDKinase inhibitor. SGTC_1527 coumarin 137 µM -0.825266613004449 0.224851720483018 no 2623 0.204610121156242 3988 323 A hepatotoxic, DNA x-linker. SGTC_2332 7982454 138.89 µM -0.8254128711463 0.224808406851058 no 2624 0.204568614999274 3827 2981748 SGTC_3037 9091026 49.47 µM -0.82893144833975 0.223767824357546 no 2625 0.203571599422542 3872 25236398 YIL048W NEO1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.831148557641613 0.223113546104966 no 2626 0.202944855707015 3919 279621 SGTC_2826 7992541 19.48 µM -0.831306148289675 0.223067081944155 no 2627 0.202900351094035 3911 2985066 SGTC_1241 0364-0022 50.8 µM -0.8319336862366 0.222882112789313 no 2628 0.202723188174122 3907 4563895 SGTC_1319 1306-0155 43.7 µM -0.832852590435289 0.222611420062991 no 2629 0.202463935241402 3913 3122360 SGTC_3267 9137951 49.47 µM -0.833074542307777 0.222546065128088 no 2630 0.202401345093592 3888 16643986 SGTC_1864 st057645 30.4 µM -0.834568898010329 0.222106328860779 no 2631 0.201980239957191 3911 688666 SGTC_1888 azatryptophan 97.5 µM -0.835046848808609 0.221965789519721 no 2632 0.201845665562584 3930 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1024 4507-0395 26 µM -0.835947430956487 0.221701115305425 no 2633 0.201592238741683 3959 4201836 SGTC_2734 clemastine 41.6 µM -0.836108518118495 0.221653792038025 no 2634 0.201546928382912 3887 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1277 0873-0036 22 µM -0.836351822764327 0.221582326331715 no 2635 0.201478503580877 3943 5965735 SGTC_3275 9138069 49.47 µM -0.837457634337209 0.221257683050421 no 2636 0.201167690567355 3988 17617007 SGTC_1632 st005650 90 µM -0.837582985192956 0.221220899821548 no 2637 0.20113247606546 3921 2759605 SGTC_2949 9072542 2.23 µM -0.837935455401807 0.221117488942643 no 2638 0.201033477306487 3964 16457352 SGTC_838 0109-0203 71.4 µM -0.838483777992075 0.220956672126905 no 2639 0.200879527354202 3888 759422 SGTC_336 4111-0029 111 µM -0.838994026891813 0.220807082049891 no 2640 0.200736330736376 3880 3131175 SGTC_1172 0370-0043 85 µM -0.839061965987523 0.22078716866672 no 2641 0.200717268883051 3940 376585 SGTC_2911 7942208 15.64 µM -0.840130924505996 0.220473985508251 no 2642 0.200417491403821 3925 1243384 SGTC_1676 st018489 23.4 µM -0.840556566913913 0.220349351822819 no 2643 0.200298199646483 3925 3696235 SGTC_536 3852-0578 10.6 µM -0.840843206057196 0.220265442881057 no 2644 0.200217889385139 3936 2869208 SGTC_1249 0481-0015 10.2 µM -0.842548146023315 0.219766728194736 no 2645 0.1997406010404 3839 4227577 SGTC_3156 9099931 49.47 µM -0.843349946701743 0.2195324164969 no 2646 0.199516378294748 3919 18111053 SGTC_3321 9137793 26.8275 µM -0.844772853839516 0.219116951191622 no 2647 0.199118836943605 3862 4904192 SGTC_723 4182-0001 115 µM -0.844929627015008 0.219071203687681 no 2648 0.199075065804489 3890 744821 YLR208W SEC13 SGTC_2218 6965428 192.983 µM -0.845551794889367 0.218889704929901 no 2649 0.198901413424762 3805 675684 SGTC_32 0928-0142 34.1 µM -0.847014173776404 0.218463440685084 no 2650 0.198493610610127 3854 2244242 SGTC_2416 tofa 880 nM -0.84843726329937 0.218049088106792 no 2651 0.198097248781131 3935 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1906 st060206 94.7 µM -0.848510552008483 0.218027761339468 no 2652 0.198076849206665 3920 5133468 SGTC_3185 9108267 49.47 µM -0.848594205190289 0.218003420015228 no 2653 0.198053566279299 3880 4910486 SGTC_533 1222-0222 6.71 µM -0.849388497246215 0.217772375736357 no 2654 0.19783257582122 3980 3982874 SGTC_419 nsc-638432 893 µM -0.850384727035081 0.217482791435189 no 2655 0.197555612309394 3876 368090 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.851977187655237 0.217020356578966 no 2656 0.197113376791785 3904 442882 SGTC_368 fentichlor 4.58 µM -0.852628706095347 0.216831325969883 no 2657 0.196932619173999 3950 7329 A pesticide. SGTC_2304 7443016 91.4 µM -0.85350028694426 0.216578595690848 no 2658 0.1966909642992 3847 939854 SGTC_1953 st076800 12.1 µM -0.854637271018473 0.216249163344642 no 2659 0.196375993731241 3947 297591 SGTC_993 3909-8757 62.7 µM -0.854692672904091 0.216233118492729 no 2660 0.196360653958374 3881 4288324 YLR208W SEC13 SGTC_3300 9124615 50.48 µM -0.855471371385798 0.216007673804502 no 2661 0.196145123391634 3972 24824903 SGTC_3243 9134147 49.47 µM -0.856620007288831 0.215675375467362 no 2662 0.195827462420035 3959 24282180 SGTC_121 0557-0495 61.343 µM -0.858400589434309 0.215160842451786 no 2663 0.195335651116379 4050 3104427 SGTC_276 colchicine 750 µM -0.859184467281952 0.214934552150516 no 2664 0.195119375767687 3990 2833 A microtubule depolymerizer. SGTC_2108 5365811 200 µM -0.859552539318923 0.214828344614668 no 2665 0.195017873308693 3958 780283 SGTC_2895 9054447 58.44 µM -0.862752818827029 0.213906186741221 no 2666 0.19413669251467 3958 2697450 SGTC_1130 3454-2858 15.9 µM -0.863121057482329 0.213800227129126 no 2667 0.194035455683648 3972 715628 YIL048W NEO1 SGTC_29 0299-0004 12.984 µM -0.863176533027434 0.213784266850626 no 2668 0.194020207035695 3803 16871 A napthoquinone isolated from Swertia calycina. SGTC_743 1275-0778 158 µM -0.863777021697398 0.213611551058684 no 2669 0.193855196526474 3918 2849257 YMR203W TOM40 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.864138475417985 0.213507626996585 no 2670 0.193755912570904 4001 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1569 carminic acid 40.6 µM -0.865289658406133 0.213176838825749 no 2671 0.193439912757821 3994 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1715 st032160 10.2275 µM -0.866235972472985 0.212905142961245 no 2672 0.193180385084029 3868 5289825 SGTC_3092 9117248 49.47 µM -0.866511819132374 0.212825982790098 no 2673 0.193104773860486 4002 17141857 SGTC_94 0334-0113 514.748 µM -0.86841896685455 0.212279155648104 no 2674 0.192582507675419 3946 6795178 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.86931913387326 0.212021340688417 no 2675 0.192336300079076 3983 165506 SGTC_482 fipronil 114 µM -0.869771170826832 0.211891942824263 no 2676 0.192212734624663 3988 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_93 0109-0045 59.227 µM -0.870336777796402 0.211730100053654 no 2677 0.192058192927977 4011 88733 SGTC_1260 0700-1617 7.75 µM -0.870352627836001 0.211725565765819 no 2678 0.192053863291801 3960 2853078 SGTC_35 0133-0054 64.071 µM -0.871032388205561 0.211531157329125 no 2679 0.191868234473608 3945 99677 SGTC_1242 0402-0103 60.1 µM -0.871176923152532 0.211489834456395 no 2680 0.19182877906525 3866 432868 SGTC_1991 st073000 8.92 µM -0.873834677606958 0.210730819352229 no 2681 0.191104146249255 4030 4301969 YIL048W NEO1 SGTC_1628 st004252 77.7 µM -0.874270804725135 0.210606420737521 no 2682 0.190985397355863 3972 692968 SGTC_1643 st009866 20.2 µM -0.875137565420359 0.210359318411235 no 2683 0.190749529744766 3912 3156273 YOR207C RET1 SGTC_3079 9117512 49.47 µM -0.875577477979437 0.210233970145094 no 2684 0.190629886776037 3951 7185044 SGTC_773 4358-1457 44.6 µM -0.876032034325297 0.210104495383737 no 2685 0.190506309539387 3898 1186886 SGTC_646 4092-0839 27.3 µM -0.876565484939403 0.209952608324409 no 2686 0.190361346587896 3988 877796 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.876974248426518 0.209836266563399 no 2687 0.190250312696424 4020 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2963 9082507 9 µM -0.87703945798552 0.209817710204573 no 2688 0.190232603270691 3994 16459611 SGTC_409 arachidonic acid 100 µM -0.879423592013157 0.209139931696546 no 2689 0.189585822528599 3940 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3146 9095609 49.47 µM -0.880038319315642 0.208965381935542 no 2690 0.189419275629682 3996 17173999 SGTC_2750 bromebric acid 70.15 µM -0.880861400205109 0.208731805284953 no 2691 0.189196420935245 4011 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_898 1000-0849 28.3 µM -0.881541366028347 0.208538958422513 no 2692 0.189012437438745 3931 6751807 SGTC_2058 5236698 133 µM -0.883254288402999 0.208053617976995 no 2693 0.188549447807622 3957 766665 SGTC_1956 st077085 54 µM -0.884273557205279 0.207765134433232 no 2694 0.188274279507644 3993 24208685 SGTC_2408 sulbentine 18.36 µM -0.88532816728421 0.207466897096544 no 2695 0.187989831195342 3946 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1235 benzylparaben 21.5 µM -0.886346465284534 0.207179168860793 no 2696 0.18771542884328 3967 7180 SGTC_2002 4023503 131 µM -0.887298959270216 0.206910247830246 no 2697 0.187458982875638 3939 4736863 YCR052W RSC6 SGTC_3023 9089636 49.47 µM -0.888356347417824 0.206611953756297 no 2698 0.187174549336438 4027 17249241 SGTC_319 1348-1596 45.5 µM -0.888401630281673 0.206599184941223 no 2699 0.187162374374627 4051 5380505 SGTC_187 1488-2104 32.728 µM -0.889307808949911 0.206343759890493 no 2700 0.186918837931404 3965 2852859 SGTC_271 rotenone 740 µM -0.893194470482841 0.205250349165242 no 2701 0.185876519376267 3978 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_979 1426-2828 121 µM -0.894260444585293 0.20495106777281 no 2702 0.185591279247273 4072 747872 SGTC_3180 9109287 49.47 µM -0.8962644014314 0.204389142477998 no 2703 0.185055783494435 4018 18891271 SGTC_1181 1222-0449 220 µM -0.897747457774974 0.20397387292612 no 2704 0.184660101056789 4000 658318 SGTC_1113 artemisinin 1.17947 µM -0.89974376726833 0.203415682244197 no 2705 0.184128312958504 3997 2240 An anti-malaria and mitochondrial poison. SGTC_1392 3455-1037 33.9 µM -0.899904650209524 0.203370737273397 no 2706 0.18408549760819 3985 981132 SGTC_1395 3486-0190 4.35 µM -0.900065978132039 0.203325673941081 no 2707 0.184042570060245 3940 6748079 SGTC_2117 5521686 200 µM -0.900530644347904 0.203195913169029 no 2708 0.183918962430436 3927 803312 SGTC_2194 5927483 104.545 µM -0.901410643007614 0.202950303864062 no 2709 0.183685012342134 3974 760979 SGTC_715 0868-0130 184 µM -0.901489740689109 0.202928236238319 no 2710 0.183663993089584 3999 2876258 SGTC_783 0848-0141 92.7 µM -0.904894557692894 0.201979678522597 no 2711 0.182760625250813 3924 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3233 9132340 49.47 µM -0.906045251916603 0.201659704317813 no 2712 0.182455950659106 3976 17682950 SGTC_2036 5160441 105 µM -0.906528192378794 0.20152550329286 no 2713 0.182328174876047 3958 134534 YIL048W NEO1 SGTC_3341 9147222 25.867 µM -0.907589410663061 0.20123079664411 no 2714 0.182047595553255 3989 1939759 SGTC_99 0109-0120 622.8 µM -0.90786016156361 0.201155648897089 no 2715 0.181976053993611 3954 759414 SGTC_2254 7938975 95.19 µM -0.909221713126432 0.20077800123925 no 2716 0.181616552504486 4057 2969277 SGTC_690 glyoxal 20.3 µM -0.911189605583823 0.20023292802592 no 2717 0.181097739925509 3796 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2502 avocadyne acetate 18.59 µM -0.911492572923386 0.200149090212631 no 2718 0.181017948568922 3913 3952079 SGTC_1863 st057641 20.1 µM -0.913289063853937 0.199652394758775 no 2719 0.180545266265596 3993 3921635 SGTC_2434 5670830 169.91 µM -0.913693143671258 0.199540776659765 no 2720 0.180439053862347 4032 1549830 SGTC_1840 st055363 71 µM -0.914850164460751 0.199221383088689 no 2721 0.180135147746455 4037 676033 SGTC_1706 st031321 9.9705 µM -0.915604009098008 0.199013451353255 no 2722 0.179937313914032 4009 6103185 SGTC_1225 1216-0074 20.6 µM -0.916920360655845 0.198650677951069 no 2723 0.179592186910001 4008 4241466 SGTC_1189 1431-2119 7.28 µM -0.919300051261604 0.197995871857602 no 2724 0.178969325514299 4006 3107275 SGTC_2313 7726885 200 µM -0.922411542114467 0.197141669645793 no 2725 0.178156975767128 4047 726423 SGTC_2687 chenodiol 100 µM -0.922983796358416 0.196984810960627 no 2726 0.178007824747766 4084 5702181 A cholesterol synthesis inhibitor. SGTC_2258 7960471 200 µM -0.92335007048181 0.19688445245651 no 2727 0.177912401246123 4024 2974708 SGTC_162 k030-0015 37.8 µM -0.924154833478012 0.196664057482547 no 2728 0.177702853842094 4075 1809920 YMR134W ERG29 SGTC_3098 9119039 49.47 µM -0.924504177813204 0.19656843145854 no 2729 0.177611938658985 3997 17161528 SGTC_1323 1348-1351 11.2 µM -0.925134213403699 0.196396043051036 no 2730 0.177448049145462 3950 6989654 SGTC_3038 9091290 49.47 µM -0.92743163376169 0.195768206617023 no 2731 0.176851236285234 4006 25236843 SGTC_2253 7938677 135.83 µM -0.928615120580316 0.195445260620265 no 2732 0.176544291445694 4087 2301972 SGTC_3121 9125696 49.47 µM -0.930303916708378 0.19498498817809 no 2733 0.176106875240688 4070 1235365 SGTC_2703 st077852 53.4 µM -0.930573614939326 0.194911544428393 no 2734 0.176037084106195 4061 6281836 SGTC_3325 9138760 55.175 µM -0.932530568333461 0.19437913434993 no 2735 0.175531198308206 3947 43844959 SGTC_2016 5121758 140 µM -0.934311455557172 0.193895395258015 no 2736 0.175071628424608 3937 2795203 SGTC_2772 vinpocetine 57.06 µM -0.934356030019612 0.193883296998925 no 2737 0.175060135486154 4028 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3223 9129970 49.47 µM -0.935141618490588 0.193670150585233 no 2738 0.174857660396926 4038 17248386 SGTC_3296 9122258 64.045 µM -0.935388211892142 0.193603274166288 no 2739 0.174794134854473 4016 4730474 SGTC_1112 tnp00069 1.16933 µM -0.937647140334646 0.192991305760191 no 2740 0.174212888548735 4033 145826 SGTC_921 1561-0023 372 µM -0.937976029302882 0.192902304762251 no 2741 0.174128364474736 3984 24050882 SGTC_396 dithiazanine 1.25 µM -0.938093398153277 0.192870549521737 no 2742 0.174098207131569 4006 10578 An antihelmenthic. SGTC_2936 9038235 15.59 µM -0.942439712019568 0.191696863190344 no 2743 0.172983781796972 3958 4749415 SGTC_170 4197-0004 226 µM -0.943995899275506 0.191277693276099 no 2744 0.172585871902782 4056 218692 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.944321760713729 0.191189991412129 no 2745 0.172502624596357 3999 641818 YHR062C RPP1 SGTC_3033 9090887 49.47 µM -0.946141026513639 0.190700810083278 no 2746 0.17203833032793 4053 19325384 SGTC_2975 9084847 53.72 µM -0.946831196481151 0.190515431844781 no 2747 0.171862401173547 4097 27211724 SGTC_3217 9129673 49.47 µM -0.948940097342516 0.189949671304656 no 2748 0.171325539741605 4071 17248312 SGTC_896 0964-0007 44.5 µM -0.94907876588123 0.189912506544688 no 2749 0.171290276592361 3970 6756758 SGTC_1411 3909-8223 150 µM -0.949093987960645 0.189908427125009 no 2750 0.171286405928788 4045 X1411 SGTC_3163 9099914 49.47 µM -0.949677427420286 0.189752109697396 no 2751 0.17113809135051 4020 16268368 SGTC_1062 mesoridazine 14.2 µM -0.950083625003082 0.189643326358437 no 2752 0.171034881463023 4030 4078 A neuroleptic. SGTC_3161 9100388 49.47 µM -0.951116905896131 0.189366777474248 no 2753 0.170772516799374 4090 25236368 SGTC_31 0508-1974 57.237 µM -0.951664033445296 0.189220443985655 no 2754 0.170633697718705 3964 6810525 SGTC_2314 7727897 200 µM -0.952764511000363 0.1889263236932 no 2755 0.170354699622679 4047 900724 SGTC_1471 k673-0312 37 µM -0.954765886937924 0.188392146255386 no 2756 0.169848051048277 3980 24099884 SGTC_504 lovastatin 124 µM -0.957646865049128 0.187624836143726 no 2757 0.169120429357327 4058 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.957673974642196 0.18761762504728 no 2758 0.169113592060999 4093 61125 An anti-inflammatory. SGTC_1460 k062-0059 9.15 µM -0.957833323309038 0.187575242088437 no 2759 0.16907340640503 3928 1373085 SGTC_1477 0139-0234 16 µM -0.958439770701203 0.187413995600526 no 2760 0.168920524367304 4056 620880 SGTC_1289 0976-0073 69.1 µM -0.958990802427794 0.187267557735467 no 2761 0.16878168934297 4087 3391136 SGTC_1006 4099-6547 255 µM -0.960855257980463 0.186772599543725 no 2762 0.168312474991201 4081 3146833 SGTC_2556 citropten 84.59 µM -0.960924845706229 0.186754141734832 no 2763 0.168294978596918 4083 2775 A potential DNA crosslinker. SGTC_811 0416-0114 265 µM -0.964700527743418 0.185754353425569 no 2764 0.167347415425849 4121 6612453 SGTC_2663 amphotericin b 100 µM -0.964716737223703 0.185750068378087 no 2765 0.167343354843627 4026 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_965 1291-5240 308 µM -0.966888313050706 0.185176557211635 no 2766 0.16679993480899 4069 2834598 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.966999890357996 0.185147119483741 no 2767 0.16677204423705 4038 5106787 A p450 inhibitor. SGTC_599 1935-0052 86.5 µM -0.968215962531304 0.184826468539313 no 2768 0.166468262240658 4049 9557311 SGTC_3324 9138759 60.749 µM -0.969280194405317 0.184546137862798 no 2769 0.166202704149195 4095 45595710 SGTC_1925 st057770 10.1 µM -0.969447348377074 0.184502131661988 no 2770 0.166161019047965 4040 5989122 SGTC_2450 5739737 12.93 µM -0.969642364992771 0.184450798383872 no 2771 0.166112394057018 4105 2262825 SGTC_2497 7-hydroxyflavone 100 µM -0.9707772215869 0.184152251892538 no 2772 0.165829613970732 4090 5281894 SGTC_2587 piperic acid 92.2 µM -0.971185973587374 0.184044795304788 no 2773 0.165727838669793 4058 5370536 SGTC_1308 1187-1617 41.4 µM -0.971781600762637 0.18388828111052 no 2774 0.165579605572267 4065 2882570 SGTC_990 3985-0011 41.3 µM -0.973004530812437 0.183567189147609 no 2775 0.165275525134394 4054 5399565 YGL099W LSG1 SGTC_2561 acetosyringone 100 µM -0.975204770424044 0.182990375708728 no 2776 0.16472934815075 4054 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3130 9127414 49.47 µM -0.975938065498875 0.182798387075065 no 2777 0.164547578569375 4070 1494646 SGTC_1710 st031758 61.5 µM -0.976627565914678 0.182617979341672 no 2778 0.164376783451338 4090 5394341 SGTC_1197 1601-0112 267 µM -0.977661115512249 0.1823477594932 no 2779 0.164120979764664 4033 7350313 SGTC_2942 9052777 62.25 µM -0.978471420019661 0.182136081517293 no 2780 0.163920609943348 4123 6469503 SGTC_924 2046-0044 21.3 µM -0.978804309767379 0.182049164385663 no 2781 0.163838339922177 4052 3623589 SGTC_2728 chlorpromazine 9.18 µM -0.979439271634676 0.181883448491086 no 2782 0.163681490434049 4094 2726 A thorazine and dopamine antagonist. SGTC_776 4476-4378 112 µM -0.985438488664259 0.180322399180505 no 2783 0.162204365917603 4134 2892008 SGTC_2339 9000433 200 µM -0.985887893766345 0.180205799456607 no 2784 0.16209406412082 4095 2988954 SGTC_2624 nerol 100 µM -0.986742142476227 0.179984292145985 no 2785 0.161884532389667 3980 637566 A natural product oil. SGTC_2811 7967822 32.47 µM -0.987172059444299 0.179872879066345 no 2786 0.161779148328794 4135 2232244 SGTC_1299 1079-1439 3.74 µM -0.990312785943765 0.179060273706471 no 2787 0.161010629479721 4039 323161 SGTC_662 k832-1615 104 µM -0.990653115487005 0.178972358590624 no 2788 0.16092749599032 4097 5878478 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.992668916441968 0.178452186909508 no 2789 0.160435663805595 4103 2374 Ca(2+)-ATPase inhibitor. SGTC_2690 usnic acid 100 µM -0.992890644996607 0.17839502868682 no 2790 0.16038162461543 4122 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1807 st050092 58.9 µM -0.99383846396787 0.178150825541531 no 2791 0.160150758392168 4104 5008496 SGTC_2723 salbutamol 83.58 µM -0.995486437394303 0.17772673135147 no 2792 0.159749868680675 4112 9884233 β2-adrenoceptor agonist SGTC_2353 9059630 146.67 µM -0.9981259806243 0.177048792096835 no 2793 0.159109136651685 4120 4779114 SGTC_1300 1094-0077 113 µM -0.998147476212815 0.177043277893659 no 2794 0.159103925657129 4060 5532636 SGTC_2066 5222451 176 µM -0.998452344750039 0.176965082503765 no 2795 0.159030030982069 4051 2281147 SGTC_713 1488-1073 324 µM -1.00071165905653 0.176386273833559 no 2796 0.158483114548011 4013 3312542 SGTC_2705 st078069 42.8 µM -1.00281098842954 0.175849526134344 no 2797 0.157976033007996 4145 1530061 SGTC_3220 9131269 49.47 µM -1.0029347091066 0.175817926065239 no 2798 0.157946182229741 4106 17722206 SGTC_2321 7390090 138.78 µM -1.0035139659687 0.175670023243802 no 2799 0.157806470959033 4135 649046 SGTC_1122 capsaicin 818.572 nM -1.00353340118445 0.17566506217827 no 2800 0.157801784776742 4161 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_292 k038-0015 474 µM -1.00459181373498 0.175395024089454 no 2801 0.157546720372716 4100 46368540 SGTC_3099 9120367 49.47 µM -1.00483298825606 0.175333528861777 no 2802 0.157488638199484 4122 24824940 SGTC_2456 5770359 74.46 µM -1.00513402387418 0.175256789299251 no 2803 0.157416159397441 4128 3118787 SGTC_2822 7994718 71.43 µM -1.01092688716 0.173784231109652 no 2804 0.156025712114514 4073 1018011 SGTC_2731 amoxapine 43.43 µM -1.011010340148 0.173763074850155 no 2805 0.156005740416876 4205 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1147 3809-1045 12.3 µM -1.01186447054072 0.173546637505951 no 2806 0.155801429584598 4072 325925 SGTC_2611 pyromycin 23.93 µM -1.01411754473557 0.172976530241783 no 2807 0.15526333360068 4080 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_952 1185-0122 232 µM -1.01522682265221 0.17269628264768 no 2808 0.154998858739179 4042 678600 SGTC_534 k292-0788 63.4 µM -1.01578538815626 0.172555276480738 no 2809 0.154865797823037 4154 4146317 SGTC_3241 9133421 49.47 µM -1.01600863490804 0.17249893985601 no 2810 0.154812637316211 4132 17018221 SGTC_455 paf C-16 10 µM -1.0162165006559 0.1724464951957 no 2811 0.154763150241427 4083 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1003 4049-0218 100 µM -1.01690497793838 0.172272864572885 no 2812 0.154599317519168 4143 295161 SGTC_48 0382-0018 55 µM -1.01746061450882 0.172132817098168 no 2813 0.154467179698083 4160 762596 SGTC_2372 9071633 200 µM -1.02015352357388 0.171455102707084 no 2814 0.153827827878404 4135 21321366 SGTC_2188 6126565 140.678 µM -1.0208671732789 0.171275787377759 no 2815 0.153658686822893 4017 874518 SGTC_1943 st076331 65.2 µM -1.02139406760551 0.171143474142948 no 2816 0.153533887428296 4126 24208415 SGTC_1215 3852-0577 11.2 µM -1.02476039032508 0.170299669688313 no 2817 0.152738130138474 4163 2884876 SGTC_906 1165-0455 526 µM -1.02519403100813 0.170191167153173 no 2818 0.152635822064129 4090 3252859 SGTC_1898 st060199 18.6 µM -1.02753464074047 0.16960628118634 no 2819 0.152084391268015 4087 688866 SGTC_1290 0986-0249 10.2 µM -1.02913407190007 0.169207348017939 no 2820 0.151708338671299 3987 53329 SGTC_1224 0823-0416 294 µM -1.03189052240876 0.168521243895142 no 2821 0.15106170316727 4190 3598164 SGTC_1880 MG-132 525 µM -1.03214872512226 0.16845706677646 no 2822 0.151001225497468 4081 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2945 9067681 61.76 µM -1.03255520567094 0.168356066571084 no 2823 0.150906050026174 4193 16456930 SGTC_1669 st015249 58.4 µM -1.03360685043378 0.1680949400308 no 2824 0.150659997773407 4197 722793 SGTC_200 k038-0079 37.545 µM -1.03388500690216 0.168025916553779 no 2825 0.150594962490553 4090 3436683 SGTC_642 0335-0876 158 µM -1.03510466103245 0.167723479362017 no 2826 0.150310018029391 4157 6812350 SGTC_1842 st055362 61.2 µM -1.03658315444181 0.167357328233665 no 2827 0.149965083698224 4102 676032 SGTC_3276 9139060 49.47 µM -1.03913852858951 0.166725701483793 no 2828 0.149370157206861 4208 4870619 SGTC_1237 0330-0133 46.1 µM -1.04080023602313 0.166315793990674 no 2829 0.148984135252161 4080 X1237 YHR072W ERG7 SGTC_2537 larixol 68.93 µM -1.04341250516252 0.165672720275428 no 2830 0.148378642149308 4128 6708759 SGTC_209 4077-0173 175.592 µM -1.04409842297174 0.16550413175784 no 2831 0.148219927720354 4114 15993494 SGTC_2381 9035592 200 µM -1.04665185571187 0.164877511357976 no 2832 0.147630088019506 4132 4749657 SGTC_1100 amiodarone 5.07 µM -1.04805487910928 0.164533859962442 no 2833 0.147306661581718 4230 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1833 st055984 71 µM -1.05075015269837 0.163874992982108 no 2834 0.146686677580806 4154 676288 SGTC_1790 st045711 43.5 µM -1.05132877719984 0.163733770194129 no 2835 0.146553807312277 4142 585119 SGTC_2153 5569715 200 µM -1.05426318086274 0.163018797521365 no 2836 0.145881220394244 4175 2054701 SGTC_3222 9128301 49.47 µM -1.05444706675382 0.162974061072961 no 2837 0.145839141574866 4161 4911358 SGTC_3228 9131799 49.47 µM -1.05860866978146 0.161963745249789 no 2838 0.1448890184278 4146 17015818 SGTC_833 3852-0053 558 µM -1.05926335214073 0.16180517966628 no 2839 0.144739930104874 4222 3123681 SGTC_2051 5263410 176 µM -1.05936638335384 0.161780234483468 no 2840 0.144716476611509 4148 227584 SGTC_89 0302-0250 142.109 µM -1.05966573039765 0.161707772930062 no 2841 0.144648349318463 4249 4203518 YLR208W SEC13 SGTC_2661 dactinomycin 12.96 µM -1.06013014000299 0.161595397317322 no 2842 0.144542698807087 4118 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3035 9091303 49.47 µM -1.06320240524257 0.160853267979632 no 2843 0.143845085944245 4217 25237002 SGTC_2894 9048625 32.47 µM -1.06400188997209 0.160660511710505 no 2844 0.14366392168341 4157 4092861 SGTC_1677 st019204 53.9 µM -1.06439659158122 0.160565404551426 no 2845 0.143574538593344 4182 3945625 SGTC_3286 9117135 37.221 µM -1.06670793795243 0.160009201771658 no 2846 0.143051870751395 4136 3438150 SGTC_707 0865-0008 204 µM -1.06750956850087 0.159816591879149 no 2847 0.14287089758581 4173 723043 SGTC_2922 7999257 32.47 µM -1.06823845617682 0.159641591817532 no 2848 0.142706480951852 4118 2988377 SGTC_2414 st077232 92.9 µM -1.07029078128755 0.159149518990714 no 2849 0.142244221318917 4107 729801 SGTC_1390 3413-2614 145 µM -1.07063374440177 0.159067385914795 no 2850 0.142167072239829 4191 3421432 SGTC_1640 st009078 66.4 µM -1.07067248428185 0.159058110203744 no 2851 0.142158359537632 4138 690618 SGTC_1914 st062367 72.6 µM -1.07080937451641 0.159025336630506 no 2852 0.142127575453881 4153 978205 SGTC_2294 7971431 200 µM -1.0719084074833 0.158762372042135 no 2853 0.14188058677806 4153 5741572 SGTC_3346 9158254 43.5805 µM -1.07684318508219 0.157585147895879 no 2854 0.140775164346067 4166 17639500 SGTC_1387 3342-1166 1.8 µM -1.07920908525228 0.157022785897342 no 2855 0.140247265238831 4144 3418228 SGTC_441 propafenone 146 µM -1.08061047055233 0.156690307292386 no 2856 0.139935211490707 4159 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2081 5214970 32.255 µM -1.08099686005983 0.156598717949906 no 2857 0.139849255181573 4136 2063512 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.0853396320067 0.155571736643214 no 2858 0.138885629425895 4231 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3339 9145883 14.936 µM -1.09057798871324 0.154338891536445 no 2859 0.137729309674239 4073 2030670 SGTC_1607 st000305 50.6 µM -1.09131592454713 0.154165739182987 no 2860 0.137566946488231 4203 5457690 SGTC_878 0828-0289 13.7 µM -1.09186746813513 0.154036406626363 no 2861 0.137445679318672 4122 745350 YLR208W SEC13 SGTC_201 4262-0159 12.803 µM -1.09197798642393 0.15401049960801 no 2862 0.137421388587059 4217 1341029 SGTC_868 0527-0199 213 µM -1.0929533158922 0.153781993856266 no 2863 0.137207148732072 4143 2849450 SGTC_2485 5633444 17.78 µM -1.09453561206017 0.153411762086845 no 2864 0.136860068714018 4198 5724239 SGTC_2600 tangeritin 87.95 µM -1.09514685539839 0.153268899237449 no 2865 0.136726152016212 4125 68077 A bioactive flavone. SGTC_1896 st058441 89 µM -1.09585212817522 0.153104168926798 no 2866 0.136571745853898 4200 688759 SGTC_3227 9130768 49.47 µM -1.09626695503961 0.153007332794175 no 2867 0.136480983059547 4240 17720899 SGTC_2177 5811945 192 µM -1.0963313976429 0.152992293120584 no 2868 0.136466886926878 4245 5343475 SGTC_124 0136-0217 7.121 µM -1.09822532081748 0.152550725250774 no 2869 0.136053056079603 4241 3976905 SGTC_556 4058-0063 51.5 µM -1.09856128403747 0.152472483877774 no 2870 0.135979736386737 4218 6615692 SGTC_3046 9092212 49.47 µM -1.09868759324269 0.152443075030249 no 2871 0.1359521780099 4248 25236637 SGTC_703 3875-0075 71.8 µM -1.09886107375355 0.152402689321041 no 2872 0.135914333943069 4243 2850814 SGTC_1822 st052468 42 µM -1.10045178108979 0.152032708826522 no 2873 0.13556766390746 4181 2873678 SGTC_1753 st043925 64 µM -1.10207164674927 0.151656559992812 no 2874 0.135215262352221 4241 670181 SGTC_2017 5132927 60.65 µM -1.10292751539388 0.15145806878578 no 2875 0.135029322039652 4184 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3109 9122853 49.47 µM -1.10361741050474 0.151298195596178 no 2876 0.134879567735303 4222 1234709 SGTC_1253 0550-0034 176 µM -1.10536373001582 0.150894013184412 no 2877 0.134501006630003 4220 5969915 SGTC_2433 5607874 27.82 µM -1.10585517708914 0.150780398380038 no 2878 0.134394604075306 4162 2252428 SGTC_591 4299-0174 154 µM -1.10708277794253 0.150496845325565 no 2879 0.134129070392102 4213 5509088 SGTC_2673 kobusone 100 µM -1.10790411768121 0.150307329523262 no 2880 0.133951613549449 4275 6710676 An epoxy ketone and protein crosslinker. SGTC_643 k048-0106 28.4 µM -1.11301995310536 0.149130483819534 no 2881 0.132849930044008 4222 6763920 SGTC_3304 9125678 46.087 µM -1.1131955812044 0.149090191929826 no 2882 0.132812220029267 4139 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1874 staurosporine 7.6 µM -1.11326292314146 0.149074744543103 no 2883 0.132797762649979 4222 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2872 9044037 25.97 µM -1.11539907132725 0.148585294036596 no 2884 0.132339723665199 4217 6465195 SGTC_260 nsc-65238 3.989 µM -1.11573957728259 0.148507374118668 no 2885 0.13226681214713 4203 3246252 SGTC_2810 7959871 45.46 µM -1.11588305629682 0.148474549182222 no 2886 0.132236097710216 4175 2974535 SGTC_2855 9016525 58.44 µM -1.12089313148904 0.147331393351451 no 2887 0.131166677450573 4171 43811474 SGTC_2336 9001819 198.65 µM -1.12479369562764 0.146445490613828 no 2888 0.130338233287821 4293 2989602 SGTC_525 k781-2675 26.7 µM -1.12684672622164 0.14598064221901 no 2889 0.12990364537332 4176 3651118 YDL195W SEC31 SGTC_3290 9121031 71.43 µM -1.12732830755516 0.145871746002014 no 2890 0.12980184910281 4229 17014854 SGTC_1887 st057648 70.8 µM -1.12810949195902 0.145695219016406 no 2891 0.129636840477071 4224 688672 SGTC_9 0092-0002 10.449 µM -1.12906906431557 0.145478577705309 no 2892 0.12943435010882 4211 759368 SGTC_931 2812-0076 566 µM -1.13133226422679 0.144968476677373 no 2893 0.12895763467599 4174 3450959 SGTC_3014 9081533 49.47 µM -1.13313475245021 0.144563077497336 no 2894 0.128578834630301 4272 21367265 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.13371418013236 0.144432920298837 no 2895 0.128457229784162 4190 688761 SGTC_3273 9137859 49.47 µM -1.1343106078915 0.144299026865869 no 2896 0.128332140526666 4320 2377234 SGTC_2818 7996756 12.99 µM -1.13736628357926 0.143614363851977 no 2897 0.127692598003117 4257 2241621 SGTC_2026 5148700 152 µM -1.1376566943048 0.14354940791374 no 2898 0.127631931512891 4205 79838 SGTC_1211 1056-0033 32.3 µM -1.13824504722869 0.143417872272476 no 2899 0.127509086640728 4284 6741922 SGTC_645 0845-0943 5.41 µM -1.13877767705177 0.143298864617289 no 2900 0.127397947373288 4240 1885106 SGTC_2455 5377712 9.75 µM -1.139513276258 0.143134616364887 no 2901 0.127244567039482 4218 2243908 SGTC_2996 9066192 71.4286 µM -1.14315558360708 0.142323218164162 no 2902 0.126486999919625 4268 6472854 SGTC_1741 st038134 10.228 µM -1.14411902801085 0.142109112751694 no 2903 0.126287138720966 4289 1272587 SGTC_777 1315-0167 517 µM -1.14499348229453 0.141914972357798 no 2904 0.126105928648058 4259 4221767 SGTC_1072 oxiconazole 14.9 nM -1.1452580032002 0.141856280618708 no 2905 0.126051148642188 4222 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1159 4092-0538 61.2 µM -1.1466032154494 0.141558060094563 no 2906 0.125772823475253 4270 717301 SGTC_113 0099-0221 2.5 µM -1.14738780487795 0.14138432048049 no 2907 0.125610689551309 4205 89219 SGTC_1546 5-methoxyflavanone 78.7 µM -1.14763098718427 0.141330499501745 no 2908 0.125560466005619 4245 147795 SGTC_502 l-744,832 89.3 µM -1.14912612870177 0.14099990076357 no 2909 0.125251987865507 4259 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1883 5-benzylidenerhodanine 20 µM -1.15428981273498 0.139862167104113 no 2910 0.124190685830538 4227 1273210 SGTC_2724 maprotiline 69.64 µM -1.1546644277439 0.13977987024444 no 2911 0.124113935966582 4179 4011 A tricyclic antidepressant. SGTC_95 0471-0001 561.058 µM -1.15645825413891 0.139386251864139 no 2912 0.123746882775064 4241 4015405 SGTC_456 gingerol 170 µM -1.16085473936169 0.138424724694685 no 2913 0.122850488826061 4291 442793 A herb. SGTC_433 pimozide 108 µM -1.16722718249457 0.137039089687244 no 2914 0.12155931813217 4164 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1794 st048918 76.9 µM -1.16808487395311 0.136853317949556 no 2915 0.121386265529977 4180 672303 SGTC_943 3253-1379 105 µM -1.16912402944179 0.136628472706745 no 2916 0.121176831890371 4273 668464 SGTC_2224 6650123 117.647 µM -1.17368163094975 0.135645314944984 no 2917 0.120261285282416 4269 2908370 SGTC_1259 0671-0132 43 µM -1.17537088430945 0.135282146265391 no 2918 0.119923183338818 4190 X1259 SGTC_1150 3909-7983 10.9 µM -1.17573669551573 0.135203589238358 no 2919 0.119850055035149 4243 23965914 SGTC_1195 1502-0147 41.1 µM -1.17701762570872 0.134928759260829 no 2920 0.119594235645247 4246 817940 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.17938458565217 0.134421925034207 no 2921 0.119122535111823 4252 688803 SGTC_444 curcumin 90.4 µM -1.18246044631763 0.133765249998412 no 2922 0.118511525518393 4202 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3315 9136395 68.55 µM -1.1828423793723 0.133683864104495 no 2923 0.118435810644129 4260 16876844 SGTC_3053 9095903 49.47 µM -1.18286298053018 0.133679475183565 no 2924 0.118431727617567 4387 17174018 SGTC_2337 9009472 200 µM -1.1841576055627 0.133403863823252 no 2925 0.118175340220629 4250 5742383 SGTC_1986 st071812 45 µM -1.1848335632404 0.133260115336719 no 2926 0.118041629716375 4213 11838594 SGTC_3301 9125354 19.7965 µM -1.18649816184969 0.13290657796598 no 2927 0.117712813479992 4272 41905162 SGTC_1853 st056710 91.2 µM -1.1877710318241 0.132636674334261 no 2928 0.11746181505324 4333 269167 SGTC_2425 5628681 7.85 µM -1.19004364538282 0.13215572110166 no 2929 0.117014619033445 4343 5714958 SGTC_2374 9071832 200 µM -1.19351876067309 0.131422609922036 no 2930 0.116333134609815 4205 17381698 SGTC_1255 0566-0045 221 µM -1.19810176270541 0.130460078772216 no 2931 0.115438701357502 4296 2788469 SGTC_350 k064-0020 19.8 µM -1.19942448630583 0.130183186671179 no 2932 0.115181465548799 4310 2790705 SGTC_2293 7624732 200 µM -1.20303383532362 0.129429694037869 no 2933 0.114481613701154 4181 894453 SGTC_557 1315-0110 16.2 µM -1.20305732569174 0.129424800074691 no 2934 0.114477068860796 4281 6833801 SGTC_2923 7992654 58.14 µM -1.20312592080342 0.129410509761789 no 2935 0.114463798035836 4286 2985126 SGTC_845 0330-0138 4.51 µM -1.20565616549661 0.12888415168826 no 2936 0.113975046629701 4238 9039800 SGTC_972 1319-0219 195 µM -1.20568918190955 0.128877293226715 no 2937 0.113968678900209 4273 23903702 SGTC_870 0573-2213 57.6 µM -1.2079443780344 0.128409423016943 no 2938 0.113534329007026 4277 3916321 SGTC_1622 st003707 19.4 µM -1.20851539493306 0.128291145333876 no 2939 0.113424538886523 4308 10140899 SGTC_2735 sertaconazole 140 nM -1.2089187365777 0.128207644695443 no 2940 0.1133470335375 4431 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1638 st008370 60.6 µM -1.21063206832219 0.12785336786049 no 2941 0.113018224087466 4244 24207134 SGTC_429 1112-0049 25.5 µM -1.21203636539123 0.127563499902011 no 2942 0.112749230278976 4282 2836170 SGTC_1621 st003705 32.4 µM -1.21692237425976 0.126558516476333 no 2943 0.111816875938304 4308 24207032 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.21769047368391 0.126401032230077 no 2944 0.111670809263091 4347 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_128 0906-2981 13.371 µM -1.2195328925563 0.126023835834411 no 2945 0.111320999696797 4293 6740226 SGTC_1873 rapamycin 2 nM -1.22056186887453 0.125813516522667 no 2946 0.111125975545447 4251 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1733 st037357 54.9 µM -1.22166589543554 0.125588129584111 no 2947 0.110916999167674 4205 1272339 YGL099W LSG1 SGTC_2059 5238311 157 µM -1.22327815257678 0.125259493800271 no 2948 0.110612328010167 4258 703021 SGTC_2800 7887935 81.82 µM -1.22427151841137 0.125057309434927 no 2949 0.11042490876261 4297 2961002 SGTC_682 0kpi-0099 17 µM -1.2247108645171 0.124967960019757 no 2950 0.110342089586508 4315 1714895 YML126C ERG13 SGTC_3019 9081971 49.47 µM -1.22514649960737 0.124879409350952 no 2951 0.110260013945231 4319 16451803 SGTC_2799 7812892 81.82 µM -1.22602623648635 0.124700720683144 no 2952 0.110094401006419 4331 20205235 SGTC_40 0327-0103 19.753 µM -1.22618884559751 0.124667711742533 no 2953 0.110063808935778 4155 409036 SGTC_2371 9071574 200 µM -1.22758776409523 0.124383989643825 no 2954 0.109800878691228 4309 45596039 SGTC_2099 5377090 177.372 µM -1.23020922854776 0.123853533082616 no 2955 0.109309382471776 4327 2243829 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.23247768926127 0.123395786950442 no 2956 0.108885347894847 4334 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_637 1181-0519 7.26 µM -1.23282600367134 0.123325606689018 no 2957 0.108820343704726 4308 6252091 YGR060W ERG25 SGTC_2219 9098279 200 µM -1.23311385070053 0.1232676308294 no 2958 0.108766645302986 4248 902349 SGTC_2355 9061122 103.12 µM -1.23401213132727 0.123086829091608 no 2959 0.108599191890301 4318 5302957 SGTC_1114 scopoletin 1.73284 µM -1.23590954444334 0.1227055378257 no 2960 0.108246094423196 4339 5280460 A coumarin with genotoxic properties. SGTC_3059 1327-0034 3 µM -1.23766784476332 0.12235294201679 no 2961 0.107919623368459 4169 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1316 1272-0050 65.9 µM -1.24159365130032 0.121568259482216 no 2962 0.107193262676781 4283 7340392 SGTC_1301 naphtanilide LB 4.81 µM -1.24175247864302 0.121536587999605 no 2963 0.107163950495165 4376 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1038 k292-0204 154 µM -1.24473989946881 0.120941951901603 no 2964 0.106613687233948 4265 4454212 SGTC_445 e6 berbamine 66 µM -1.24475596094466 0.120938760461238 no 2965 0.106610734338012 4340 6610268 A calcium/calmodulin antagonist. SGTC_724 3910-0327 137 µM -1.24513161850249 0.120864133618171 no 2966 0.106541686682333 4359 2885483 SGTC_1748 st037455 53.6035 µM -1.2462830844365 0.120635589272351 no 2967 0.10633024288504 4360 580690 SGTC_582 0987-0078 156 µM -1.24684770680004 0.120523633590159 no 2968 0.106226672031274 4382 1625765 SGTC_2805 7950783 58.44 µM -1.24717740090131 0.120458294310466 no 2969 0.106166228680635 4339 1178958 YDL195W SEC31 SGTC_1452 4194-0072 190 µM -1.24790702199325 0.1203137855927 no 2970 0.106032554407708 4385 1343545 SGTC_1433 4060-0023 7.6 µM -1.25156910781307 0.119590317895033 no 2971 0.105363458556304 4349 3840627 SGTC_2067 5224629 34.075 µM -1.25341005054228 0.119227789589346 no 2972 0.105028257826322 4322 2835000 SGTC_2762 leflunomide 42.06 µM -1.25546916713996 0.118823217140167 no 2973 0.104654247078031 4306 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_678 1218-2179 85.9 µM -1.25725948278442 0.11847224721453 no 2974 0.104329845201611 4358 6820081 YOR116C RPO31 SGTC_805 3852-0218 479 µM -1.25826677152976 0.118275102723982 no 2975 0.1041476470137 4294 6615355 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.25935762236411 0.118061865367116 no 2976 0.103950594418287 4319 688667 SGTC_2830 7992007 71.43 µM -1.26040571576942 0.117857242423702 no 2977 0.103761520399581 4208 1952075 SGTC_2087 5276107 200 µM -1.26559549794181 0.116847720813683 no 2978 0.102828969370493 4291 144405 SGTC_2109 5483026 200 µM -1.26619793117532 0.116730933156566 no 2979 0.102721114010153 4351 759335 SGTC_2534 helenine 20.12 µM -1.26656363320773 0.116660078570526 no 2980 0.102655681436003 4355 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_278 4092-0821 23.9 µM -1.26792469896944 0.116396640736199 no 2981 0.10241242140796 4337 877900 SGTC_3036 9090181 49.47 µM -1.26944138225272 0.116103580194895 no 2982 0.102141842335369 4393 25236586 SGTC_2683 piperine 63.03 µM -1.27074347534458 0.115852401888662 no 2983 0.101909961768624 4346 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.27313160182336 0.115392727290087 no 2984 0.101485673331577 4347 140250 A respiratory chain inhibitor. SGTC_1699 st031318 29.054 µM -1.27389430514899 0.115246193051987 no 2985 0.101350438468953 4402 5340658 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.27778454508969 0.114500839410527 no 2986 0.100662702595449 4322 6857784 SGTC_3311 9131146 2.8755 µM -1.28027947514964 0.114024630936917 no 2987 0.100223431757411 4303 4900406 YPR165W RHO1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.28175211286182 0.113744210964028 no 2988 0.0999648088030589 4388 6708784 An antioxidant flavonoid SGTC_17 0960-0276 49.807 µM -1.28179769955283 0.113735538187662 no 2989 0.099956810704591 4325 6821114 SGTC_389 tpck 16.7 µM -1.28420276874066 0.113278646838924 no 2990 0.0995355083438003 4395 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1976 st070609 63.5 µM -1.28450398964472 0.113221516249712 no 2991 0.0994828342601077 4300 682556 SGTC_640 3381-0960 37.1 µM -1.28500760535478 0.113126044687525 no 2992 0.099394813188029 4397 1745025 SGTC_3088 9117578 49.47 µM -1.28799539969763 0.112560823030156 no 2993 0.0988737822778014 4423 678341 SGTC_1985 st071382 65.5 µM -1.28951522649494 0.11227408217681 no 2994 0.0986095131360675 4346 6123237 SGTC_373 0844-0104 25.9 µM -1.29174265065113 0.111854784925122 no 2995 0.0982231409236216 4378 5375804 SGTC_2106 5357045 167.29 µM -1.29223757103827 0.111761771827024 no 2996 0.0981374420942471 4376 668842 SGTC_1993 st073995 70.8 µM -1.29323883908423 0.111573767248638 no 2997 0.097964233263083 4349 3098394 SGTC_2260 7964312 200 µM -1.29376655756902 0.111474770517067 no 2998 0.0978730337253747 4414 231951 SGTC_300 r073-0011 5.04 µM -1.2952701525351 0.111193050128453 no 2999 0.097613525912792 4359 2735780 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.3003744235788 0.11024049418095 no 3000 0.0967363357590883 4362 521171 SGTC_1683 st010134 710 nM -1.30136217642974 0.110056838232509 no 3001 0.0965672569649902 4347 3818134 SGTC_1226 3909-7979 35.4 µM -1.30243338863282 0.109857912657325 no 3002 0.0963841374973955 4360 6615510 SGTC_1429 4049-0205 9.46 µM -1.30405925562323 0.10955648020362 no 3003 0.0961066897713863 4407 22774478 SGTC_119 0121-0043 24.815 µM -1.30545037170397 0.109299041945897 no 3004 0.095869767859466 4379 1092378 SGTC_307 1501-1223 22.3 µM -1.30577184517971 0.109239612322139 no 3005 0.0958150786553146 4394 2830329 SGTC_2393 9031399 185.94 µM -1.31190867778596 0.108109567564398 no 3006 0.0947754746073279 4384 1526623 YDL150W RPC53 SGTC_1318 1280-3875 124 µM -1.3129803611709 0.107913092595088 no 3007 0.0945947829295358 4379 373245 SGTC_1995 st072814 61.1 µM -1.31423064219247 0.107684199934007 no 3008 0.0943842998159694 4348 5769371 SGTC_2446 5162541 200 µM -1.31433549696728 0.107665019768105 no 3009 0.0943666633662124 4353 1549321 SGTC_560 2332-1943 155 µM -1.31633355906261 0.107300001984081 no 3010 0.0940310559188892 4369 21177716 SGTC_2867 9039098 71.43 µM -1.31791394805849 0.107011919748156 no 3011 0.0937662279747253 4361 6463460 SGTC_2413 inermin 26.06 µM -1.31962484526919 0.106700677101268 no 3012 0.0934801517221516 4431 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3211 9128781 49.47 µM -1.32297177939912 0.106093700419602 no 3013 0.0929223814268252 4340 17194361 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.3231057944524 0.106069448431763 no 3014 0.0929000990122555 4358 16623 A steroid. SGTC_2152 5568786 200 µM -1.32324083872528 0.106045014243467 no 3015 0.0928776494677107 4403 5399883 SGTC_1102 cgs 12066b 26.1 µM -1.3255359806719 0.105630365295345 no 3016 0.092496721889593 4394 6438352 A 5-HT1B full agonist. SGTC_709 3807-1509 243 µM -1.32568256226589 0.105603923197594 no 3017 0.0924724328858722 4454 1886677 YPL242C IQG1 SGTC_1659 st012954 42.1 µM -1.32727859297912 0.105316322294367 no 3018 0.0922082712408004 4350 24207262 SGTC_2992 9074591 71.4286 µM -1.32790585697704 0.105203446081096 no 3019 0.0921046048022817 4342 17741321 SGTC_768 0384-0033 77.3 µM -1.33324594105618 0.104246040956201 no 3020 0.0912255537748587 4342 3965305 YMR134W ERG29 SGTC_2549 cedrol 20.94 µM -1.33367450430356 0.104169479985078 no 3021 0.0911552769756428 4331 6708665 A sedative which affects the nervous system. SGTC_1623 st003709 20.3 µM -1.33522383896813 0.103893038100825 no 3022 0.0909015483943374 4361 16192618 SGTC_1015 4130-4525 82 µM -1.33551512123332 0.103841125189337 no 3023 0.0908539047887394 4398 1363237 SGTC_2813 7971799 71.43 µM -1.3359603767713 0.103761807217764 no 3024 0.090781112344186 4406 2234054 SGTC_970 1315-0089 19.5 µM -1.33622645809798 0.103714428386068 no 3025 0.0907376327964512 4353 6811083 YLR033W RSC58 SGTC_1087 pterostilbene 9.05 µM -1.33642832445291 0.10367849423853 no 3026 0.0907046567349563 4389 5281727 Similar to reservatol, lowers cholesterol. SGTC_233 rapamycin 362 pM -1.3382591680904 0.103352998930666 no 3027 0.0904059836622795 4381 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3210 9128157 49.47 µM -1.34040039764159 0.102973263792734 no 3028 0.0900576032628931 4361 17590849 SGTC_138 0850-0259 40.9225 µM -1.34356513941759 0.102413872071512 no 3029 0.0895445243449915 4322 6813004 SGTC_804 1595-0054 20.9 µM -1.34548030224382 0.102076427782844 no 3030 0.0892350891012618 4370 761523 Stimulates phospholipase C. SGTC_3167 9103034 49.47 µM -1.35082046234724 0.101139786389296 no 3031 0.0883764758193356 4490 5127859 SGTC_2528 xanthyletin 44.79 µM -1.3524266141045 0.100859303235347 no 3032 0.0881194401554869 4429 65188 An natural product with antifungal activity of unknown mechanism. SGTC_158 k038-0087 26.446 µM -1.3559491763382 0.100246143090443 no 3033 0.0875576696680076 4314 X158 SGTC_531 3788-1495 174 µM -1.35713374799419 0.100040561401608 no 3034 0.0873693585151484 4396 2896655 SGTC_733 4069-0007 56.1 µM -1.36030194093844 0.0994922365054932 no 3035 0.0868671972138401 4418 5717425 YNL287W SEC21 SGTC_999 SEC7.066 22.7 µM -1.36112417289385 0.0993502910134097 no 3036 0.0867372258668236 4359 740511 YDR170C SEC7 SGTC_2710 st078562 53.7235 µM -1.36254894801216 0.0991046765077429 no 3037 0.0865123538561448 4364 17250908 SGTC_2079 5212404 121 µM -1.36284252992091 0.0990541216625873 no 3038 0.0864660720787196 4365 758462 SGTC_2526 patulin 37.61 µM -1.36333206739189 0.0989698651975374 no 3039 0.0863889400207024 4434 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2844 9010103 25.97 µM -1.36471281592602 0.0987325009541525 no 3040 0.086171664990438 4396 2480525 SGTC_3013 9080133 71.4286 µM -1.36498000699926 0.0986866163350359 no 3041 0.0861296669635432 4475 17050193 SGTC_286 k060-0067 22.9 µM -1.36701389443948 0.098337849132351 no 3042 0.0858104752142012 4437 5985051 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.37091656438935 0.097671156041832 no 3043 0.085200483531453 4417 551469 SGTC_2778 tioconazole 65.09 nM -1.37482729320698 0.0970064166160609 no 3044 0.0845924972014593 4308 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1116 jasmonic acid  1.58368 µM -1.37531689637647 0.0969234291299969 no 3045 0.0845166102275777 4454 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1572 epiandrosterone 68.9 µM -1.37929780260782 0.096250601650387 no 3046 0.0839014768857537 4358 441302 A steroid. SGTC_2962 9082311 13.18 µM -1.38041968476677 0.0960616097896207 no 3047 0.0837287313723269 4390 16459453 SGTC_755 1995-0008 37.3 µM -1.38089519529972 0.0959815878443334 no 3048 0.0836555937411247 4380 689533 SGTC_914 3820-6779 408 µM -1.38551838642862 0.0952061216594332 no 3049 0.0829470071755373 4362 2893481 SGTC_2482 5981709 142.65 µM -1.38559426904667 0.0951934321642322 no 3050 0.0829354145873417 4365 877755 SGTC_2871 9038510 12.99 µM -1.388912098535 0.094639824105291 no 3051 0.082429740547139 4402 4945164 SGTC_355 1311-2252 105 µM -1.3911501380068 0.0942677308161127 no 3052 0.0820899518544653 4404 5338538 SGTC_2365 9042475 200 µM -1.39432543411887 0.0937416636383699 no 3053 0.0816096768999388 4474 6464479 SGTC_761 k216-0224 480 µM -1.39436594529437 0.0937349659800352 no 3054 0.081603563155703 4435 1340404 SGTC_248 streptozotocin 5.23457 mM -1.39574969308752 0.0935064048875735 no 3055 0.0813949421424795 4456 5300 DNA alkylating agent. SGTC_1278 0874-0585 172 µM -1.39936326992554 0.0929114722896898 no 3056 0.0808520377125973 4492 766306 SGTC_2654 protoveratrine a 100 µM -1.40167234389846 0.0925327788870482 no 3057 0.0805065564316034 4454 5702278 A heart drug and vasodilator. SGTC_877 0771-0151 33.1 µM -1.40434527301832 0.0920958397953061 no 3058 0.0801080294931838 4452 6166523 SGTC_1555 citronellol 128 µM -1.40674305901096 0.0917051793160688 no 3059 0.0797517962881559 4405 8842 A terpine precursor. SGTC_1174 0739-0097 51.1 µM -1.40732076377294 0.0916112402790608 no 3060 0.0796661475042428 4466 728447 SGTC_2203 7227154 166.4 µM -1.40807446919361 0.091488789464654 no 3061 0.0795545100278884 4461 896304 SGTC_181 1447-1644 8.07 µM -1.41053927560074 0.0910891915057459 no 3062 0.0791902538764603 4395 534600 SGTC_689 0833-0039 98 µM -1.41095282803746 0.0910222727974853 no 3063 0.0791292618232272 4406 5374726 SGTC_543 3844-1095 191 µM -1.41151689690162 0.0909310571740202 no 3064 0.079046128476555 4450 4230703 SGTC_2145 5634607 200 µM -1.42124834098548 0.0893680453246677 no 3065 0.0776222878658554 4435 308662 SGTC_3239 9133757 49.47 µM -1.42356650631827 0.088998679061403 no 3066 0.0772859986324249 4512 17036923 SGTC_2465 5809242 33.21 µM -1.42625819103121 0.0885712250347084 no 3067 0.0768969140556337 4513 2731748 SGTC_2614 arthonioic acid 13.39 µM -1.42660257642389 0.0885166453199481 no 3068 0.0768472405845332 4314 6710684 SGTC_289 k017-0060 526 µM -1.42769225255517 0.0883441137148805 no 3069 0.0766902285507745 4442 5512909 SGTC_1591 genipin 88.4 µM -1.43341653525683 0.0874418856359662 no 3070 0.0758694178700648 4469 442424 A DNA cross-linking agent. SGTC_544 k015-0020 52.4 µM -1.43643040997762 0.0869696286759424 no 3071 0.0754399525496707 4477 3008304 SGTC_789 1309-1135 70.6 µM -1.43866194378602 0.0866211895495557 no 3072 0.0751231633342149 4438 3092424 SGTC_1809 st050081 57.6 µM -1.43939194946965 0.0865074308317456 no 3073 0.0750197520038655 4516 5036894 SGTC_479 n-linoleoylglycine 10 µM -1.44019219827392 0.0863828543101503 no 3074 0.0749065149354025 4490 6433346 An anti-infammatory. SGTC_1014 4130-3005 69.3 µM -1.44023115737391 0.0863767928860312 no 3075 0.0749010054622273 4481 743608 SGTC_2223 6903751 107.57 µM -1.44063719669467 0.0863136384739743 no 3076 0.0748436030590841 4441 5598863 SGTC_1816 st051957 91.6 µM -1.44251937455354 0.0860213398894662 no 3077 0.0745779549671942 4463 674121 SGTC_1709 st033179 39.1045 µM -1.44846227053399 0.0851032808317903 no 3078 0.073743905225154 4469 573381 SGTC_132 0417-1715 25.805 µM -1.4511388206035 0.08469221347901 no 3079 0.0733706042711589 4453 6769098 SGTC_1652 st011932 78 µM -1.4535104354441 0.0843292242462289 no 3080 0.0730410422106868 4400 1551076 SGTC_1648 st011736 69.8 µM -1.45392296108653 0.0842662042122582 no 3081 0.0729838330680121 4454 2855514 SGTC_1545 lovastatin 49.4 µM -1.45562116621829 0.0840071478341998 no 3082 0.0727486867642116 4486 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2136 5328288 199.296 µM -1.45566851691092 0.0839999331990456 no 3083 0.0727421385526921 4440 262395 SGTC_203 k066-0004 30.888 µM -1.4569971418455 0.0837976855683774 no 3084 0.0725585845903648 4528 6795412 SGTC_2300 7976697 71.57 µM -1.45846368065559 0.0835748691612423 no 3085 0.0723563895163859 4360 2236109 SGTC_1412 3909-8563 178 µM -1.46051686244751 0.083263670346189 no 3086 0.072074038312076 4557 23767530 SGTC_1011 4112-3381 17.4 µM -1.46192269493153 0.0830510926620213 no 3087 0.0718811975346321 4512 2877139 SGTC_2907 7721985 69.9 µM -1.46494951786948 0.0825947888773489 no 3088 0.0714673456691626 4469 3267881 SGTC_2529 gangaleoidin 93.61 µM -1.46552895404823 0.0825076525229586 no 3089 0.0713883293819339 4467 4565183 SGTC_823 0417-1665 178 µM -1.46606188446133 0.0824275708768833 no 3090 0.0713157141843202 4493 3429856 SGTC_2440 5628896 157.78 µM -1.46802569278054 0.0821329811675934 no 3091 0.0710486220155859 4446 5522048 SGTC_932 2857-0803 154 µM -1.46840356623774 0.0820763876950542 no 3092 0.0709973167317931 4479 674898 SGTC_2011 4012611 177 µM -1.47344586391254 0.0813240203456497 no 3093 0.0703154255512306 4447 2049887 SGTC_408 cantharidin 100 µM -1.47966302238057 0.0804035269841191 no 3094 0.0694815992579728 4469 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1339 1486-1321 22.7 µM -1.4801021494098 0.0803388100524191 no 3095 0.0694229940260837 4518 3469382 SGTC_231 b-estradiol 524 µM -1.48076398992209 0.0802413448050718 no 3096 0.0693347377279178 4477 450 A steroid. SGTC_2383 9036125 200 µM -1.48196097070058 0.0800652996921573 no 3097 0.0691753401157013 4430 79580 SGTC_2132 5317594 122.667 µM -1.48210072322921 0.0800447647373412 no 3098 0.0691567481979287 4424 794577 SGTC_3191 9110352 49.47 µM -1.48286491857204 0.0799325458266905 no 3099 0.0690551518814231 4438 17122424 SGTC_1879 gemcitabine 100 µM -1.48412701224701 0.0797474731579056 no 3100 0.0688876141355218 4442 60750 A nucleoside analog which inhibits DNA replication. SGTC_806 3966-4455 5.86 µM -1.48864713865644 0.079087303263711 no 3101 0.0682901558499558 4463 714982 SGTC_384 k007-0144 5.16 µM -1.49522711555598 0.0781336985103504 no 3102 0.0674275895665668 4435 6824886 SGTC_1810 st050138 53 µM -1.49588529940701 0.0780387929847467 no 3103 0.0673417738981489 4501 3444541 SGTC_104 0074-0074 590.992 µM -1.49802187338892 0.0777313166232726 no 3104 0.0670637837805082 4349 3943124 SGTC_2653 dihydrofissinolide 100 µM -1.50010261071813 0.0774327604913844 no 3105 0.0667939123980908 4554 6857746 SGTC_3335 9143315 29.6265 µM -1.50387507625025 0.0768936875350663 no 3106 0.0663067677865758 4498 4899691 SGTC_2134 5324836 1.464 µM -1.50459500175524 0.0767911374937781 no 3107 0.0662141160487775 4474 699272 SGTC_2168 5727979 200 µM -1.5051371438266 0.07671398054017 no 3108 0.0661444105905391 4403 695210 SGTC_469 w7 172 µM -1.50744568260231 0.0763860921624924 no 3109 0.0658482283694987 4596 45115570 A P450 inhibitor. SGTC_82 0054-0107 293.755 µM -1.50749727280003 0.0763787768589634 no 3110 0.0658416211822956 4466 3104697 SGTC_2849 9019321 12.99 µM -1.51094621531233 0.0758909372964238 no 3111 0.0654010773665714 4510 16489627 SGTC_954 1189-0853 2.85 µM -1.51153403179909 0.0758080301220425 no 3112 0.0653262223648718 4430 2828194 SGTC_1212 0520-0165 585 µM -1.51236983345144 0.0756902652693615 no 3113 0.0652199023549298 4549 5403258 SGTC_420 mitomycin C 81.9 mM -1.51390761214401 0.0754739556803494 no 3114 0.0650246366064754 4486 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_521 r062-0005 13.8 µM -1.514120542938 0.0754440412230317 no 3115 0.0649976346491264 4429 2832033 SGTC_2092 5303694 80.6725 µM -1.51654155988444 0.0751045498816242 no 3116 0.0646912348928693 4514 1963699 SGTC_354 2783-3500 4.88 µM -1.51735568234686 0.0749906502544321 no 3117 0.0645884533551121 4480 6740761 SGTC_2459 5811157 9.22 µM -1.51753830336389 0.0749651188009655 no 3118 0.0645654151981226 4457 2870684 YBR192W RIM2 SGTC_698 k064-0052 127 µM -1.52439808282406 0.074010877285238 no 3119 0.0637046493696738 4586 5088751 SGTC_555 4296-0685 37 µM -1.52717849299097 0.0736267572309872 no 3120 0.063358316389519 4498 2908540 YHR072W ERG7 SGTC_1423 4048-0112 5.59 µM -1.52838690161477 0.0734602887370228 no 3121 0.0632082524976931 4565 X1423 SGTC_2720 fluspirilene 36.88 µM -1.52857214157683 0.0734347958315703 no 3122 0.0631852733146383 4495 3396 An atypical antipsychotic. SGTC_1380 2291-0730 164 µM -1.53017720254743 0.0732141889868006 no 3123 0.06298643635522 4517 2999191 SGTC_3063 1327-0034 4 µM -1.53117582704064 0.073077189608251 no 3124 0.0628629716840876 4394 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_569 4130-2812 160 µM -1.53188977546528 0.0729793647191564 no 3125 0.0627748185149325 4383 743552 SGTC_2990 9074105 71.4286 µM -1.53303960459808 0.0728220263978659 no 3126 0.0626330484962189 4444 6502001 SGTC_2232 chlorophetanol 41.5365 µM -1.5337066146424 0.0727308743330753 no 3127 0.0625509228742721 4594 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3165 9101544 49.47 µM -1.53474984301526 0.072588484349086 no 3128 0.0624226437192495 4502 5002184 SGTC_2571 chrysanthemic acid 100 µM -1.53612669758191 0.0724008847838394 no 3129 0.0622536548060926 4494 2743 An insecticide. SGTC_2964 9083345 53.42 µM -1.55293968614403 0.0701399400522781 no 3130 0.0602187722360304 4489 17741579 SGTC_2760 etidronate 98.04 µM -1.5539726236718 0.0700028257636156 no 3131 0.0600954734569873 4476 3305 A chelator and antioxidant. SGTC_2575 plumbagin 510 nM -1.55415668191245 0.0699784151500918 no 3132 0.0600735237184199 4452 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3331 9141060 1.957 µM -1.55940567344766 0.0692850240387197 no 3133 0.059450197172604 4472 4906567 YPR165W RHO1 SGTC_10 0279-0212 42.575 µM -1.56765246188801 0.0682063304683729 no 3134 0.0584811307943982 4552 39851 YBR002C RER2 SGTC_379 3970-0972 5.9 µM -1.56866127260912 0.0680752710675591 no 3135 0.0583634435116151 4527 2898042 YBL034C STU1 SGTC_2495 cafestol 54.53 µM -1.57228965581366 0.0676054972273856 no 3136 0.0579416954568263 4513 16667697 An anti-infammatory. SGTC_2714 st079313 56.9 µM -1.5821371070865 0.0663431507080371 no 3137 0.0568091370846735 4530 2939799 SGTC_2984 9022109 38.96 µM -1.58328885124045 0.066196708566743 no 3138 0.0566778214184062 4551 6459207 SGTC_304 1310-0298 97 µM -1.58478308968201 0.0660070921843456 no 3139 0.0565078128935963 4276 1550234 SGTC_1904 st060225 78 µM -1.58665303387989 0.0657703925441023 no 3140 0.0562956244700128 4522 66595 SGTC_2464 5717415 7.67 µM -1.59848701994719 0.0642876602749185 no 3141 0.0549673159376065 4519 5285744 SGTC_54 0159-0055 9 µM -1.60066861404251 0.0640171768819599 no 3142 0.0547251681325238 4521 3319099 SGTC_826 1683-5028 118 µM -1.60231735952234 0.0638133460558372 no 3143 0.0545427244177741 4587 722377 SGTC_1337 1486-1011 40.3 µM -1.60263985086705 0.0637735362408052 no 3144 0.0545070950964588 4542 X1337 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.60330013059069 0.0636920885460082 no 3145 0.0544342038417738 4553 75037 A free radical scavenger. SGTC_3172 9105863 49.47 µM -1.60445396508174 0.0635499535338579 no 3146 0.0543070119663322 4635 2348785 SGTC_2394 5221648 200 µM -1.60497634547061 0.0634856853717931 no 3147 0.0542495052264248 4569 788586 SGTC_195 4234-0266 16.654 µM -1.60527751053758 0.0634486561993401 no 3148 0.0542163730881905 4570 2303354 SGTC_2031 5180455 200 µM -1.6071587338823 0.0632177343298633 no 3149 0.0540097759031986 4547 29949 SGTC_2853 9015042 58.44 µM -1.60852497358283 0.0630504377711407 no 3150 0.0538601255824326 4476 6457456 SGTC_34 0469-0683 81.75 µM -1.60868658392945 0.0630306713524753 no 3151 0.0538424454179069 4533 3690923 SGTC_2453 5731132 22.18 µM -1.60922927553672 0.0629643305380011 no 3152 0.0537831086056972 4582 1362040 SGTC_1565 sinapyl alcohol 95.1 µM -1.61104390400557 0.0627428979844964 no 3153 0.0535850767724349 4546 5280507 A phenol propionate derived from cinnamic acid. SGTC_1144 3486-0183 12.5 µM -1.61426575337149 0.0623512431706098 no 3154 0.0532348975205 4559 6744069 SGTC_5 0352-0601 109.883 µM -1.61434489019039 0.0623416471767507 no 3155 0.0532263191080214 4455 762456 SGTC_2484 5809818 12.04 µM -1.62005081153838 0.0616527873918635 no 3156 0.0526106812109549 4531 2870548 SGTC_216 k038-0035 28.382 µM -1.62068463529604 0.0615766358412356 no 3157 0.0525426452334999 4490 4444231 YPR107C YTH1 SGTC_912 3474-0017 2.18 µM -1.62104654078029 0.0615331872083876 no 3158 0.052503828868621 4564 3360550 SGTC_3356 9151811 4.48 µM -1.62249677571886 0.0613593191383176 no 3159 0.0523485114627662 4580 1859254 YPR165W RHO1 SGTC_1548 st061468 90.8 µM -1.62486926652814 0.0610757099864426 no 3160 0.0520952090124212 4611 390799 SGTC_1432 4049-0298 68.4 µM -1.62665574168589 0.0608628305705621 no 3161 0.0519051167402581 4587 741646 SGTC_1111 tnp00062 510.699 nM -1.6274892232352 0.0607637101813303 no 3162 0.0518166177937186 4556 676306 SGTC_909 3448-9333 149 µM -1.62787625503037 0.0607177260192727 no 3163 0.0517755636088982 4485 3344074 SGTC_2326 6164455 177.58 µM -1.6308503401364 0.0603652755320972 no 3164 0.0514609511971803 4490 2888790 SGTC_2804 7954240 19.48 µM -1.63237560952787 0.0601851423149619 no 3165 0.0513001920118937 4570 828705 SGTC_2359 9039622 200 µM -1.63513941198887 0.05985981161096 no 3166 0.0510099129014647 4520 6463596 SGTC_430 0958-0115 16.4 µM -1.63588489412973 0.0597722962669529 no 3167 0.0509318400267152 4490 6833180 SGTC_1782 st039423 80.636 µM -1.63639301465585 0.0597127032879686 no 3168 0.0508786801018017 4574 2068169 SGTC_2072 5231554 129 µM -1.63723846974689 0.0596136504903336 no 3169 0.0507903259066028 4622 789545 SGTC_345 1362-0200 395 µM -1.63810857933089 0.0595118436900987 no 3170 0.0506995228093523 4550 1419823 SGTC_1065 prochlorperazine maleate 2.48 µM -1.64102557141681 0.0591715362287284 no 3171 0.050396053578364 4593 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2317 5986382 200 µM -1.64146668332199 0.0591202075353657 no 3172 0.0503502887593688 4584 877883 SGTC_2572 astragaloside iv 100 µM -1.64597838974121 0.0585972192394835 no 3173 0.0498841041346556 4528 45006101 An anti-inflammatory agent. SGTC_880 0833-0487 87.2 µM -1.64636993413568 0.0585520039947359 no 3174 0.0498438096059004 4559 76075 SGTC_1798 st045719 60.953 µM -1.64640163238564 0.0585483447041993 no 3175 0.0498405486190438 4542 3980186 SGTC_1124 fisetin 1.16336 µM -1.6486042959732 0.0582945055841861 no 3176 0.049614364029569 4571 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2102 5377816 72.7585 µM -1.65008245514401 0.0581246450021178 no 3177 0.0494630363381591 4598 1379702 SGTC_2458 5808907 16.39 µM -1.65553268205224 0.057501698390967 no 3178 0.0489082463168692 4666 2731747 SGTC_251 melphalan 456.522 µM -1.65840327825408 0.0571757148024159 no 3179 0.0486180476793381 4603 460612 A DNA alkylator. SGTC_586 0957-0265 8.15 µM -1.658569644138 0.0571568670527336 no 3180 0.0486012714614658 4491 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_944 3370-0224 231 µM -1.66081750454229 0.0569026839619991 no 3181 0.0483750522328536 4534 4580514 SGTC_77 0828-0286 12.516 µM -1.66126105703953 0.0568526333352134 no 3182 0.0483305138256523 4469 745345 SGTC_2980 9014342 25.29 µM -1.66513372885572 0.0564171111506878 no 3183 0.0479430394473307 4587 2996599 SGTC_3051 9093778 49.47 µM -1.67095656964869 0.0557672264324605 no 3184 0.0473651282579795 4677 17217378 SGTC_1728 st035614 33.7865 µM -1.67655783868918 0.0551476595530798 no 3185 0.0468144885554089 4528 15945546 SGTC_2566 crystal violet carbinol 226 nM -1.67805135429817 0.0549833805774547 no 3186 0.0466685370561726 4524 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_787 4152-0075 138 µM -1.68413790974963 0.0543178868015944 no 3187 0.0460775097037273 4612 9566539 SGTC_2912 7964298 10.93 µM -1.68563839323274 0.0541548095366335 no 3188 0.0459327347845271 4565 2975850 SGTC_1229 0139-0193 12.2 µM -1.68568025358753 0.0541502655832255 no 3189 0.0459287011131121 4631 3090752 SGTC_397 arbidol 50 µM -1.68647419453273 0.0540641401870347 no 3190 0.0458522506955229 4593 131410 A RNA synthesis inhibitor. SGTC_2227 7312221 64.1025 µM -1.68823915406661 0.0538730687347413 no 3191 0.0456826649833543 4684 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2897 9048598 12.99 µM -1.68848026192557 0.0538470083778717 no 3192 0.0456595373858781 4563 6467404 SGTC_1170 0310-0127 64.8 µM -1.69129677246174 0.0535433221646084 no 3193 0.0453900680832113 4600 774975 SGTC_2419 paclitaxel 166.5 µM -1.69242228592862 0.0534223454125633 no 3194 0.0452827430571061 4527 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3320 9137005 35.139 µM -1.6979053412606 0.0528360895619433 no 3195 0.0447628145045529 4613 4908713 SGTC_1154 4088-0362 150 µM -1.69992400448852 0.0526215410768918 no 3196 0.0445726105279842 4603 6618304 SGTC_2597 laccaic acid a 100 µM -1.70359263926577 0.0522334000859944 no 3197 0.0442286087886593 4554 5491415 A textile dye. SGTC_1467 k284-1082 293 µM -1.70659760688618 0.0519171718189126 no 3198 0.043948435145043 4564 3334705 SGTC_661 1304-0007 33.6 µM -1.73648870453965 0.0488537659706666 no 3199 0.0412387299432304 4620 3117130 SGTC_272 doxorubicin 8.13 µM -1.73939791235413 0.0485634936223599 no 3200 0.0409823976041676 4631 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1775 st081588 35.1725 µM -1.7394536399202 0.0485579467767953 no 3201 0.0409775000527052 4576 1426443 YGL099W LSG1 SGTC_879 0831-1030 162 µM -1.7400197207994 0.0485016305963033 no 3202 0.0409277775998165 4608 1549252 SGTC_3312 9133330 71.43 µM -1.74208920869572 0.0482961933131235 no 3203 0.0407464177882428 4616 17617324 SGTC_748 act1.228 77.9 µM -1.74352713475059 0.0481538612262082 no 3204 0.0406207893565548 4585 4421505 YNR035C ARC35 SGTC_3134 9127454 49.47 µM -1.74444952439706 0.0480627359836708 no 3205 0.0405403678498567 4637 24262820 SGTC_2699 st077704 54.6 µM -1.74744128865319 0.0477681213047938 no 3206 0.0402804103660009 4594 645852 SGTC_982 1491-0518 27.5 µM -1.74869598979215 0.047644995503749 no 3207 0.0401717918049631 4578 3091256 SGTC_840 0245-0196 390 µM -1.75047233475687 0.0474711147777969 no 3208 0.0400184219267005 4673 3827528 SGTC_3184 9108758 49.47 µM -1.75441593504402 0.047086905520332 no 3209 0.0396796314175071 4658 902885 SGTC_277 nystatin 15.5 µM -1.75492152063286 0.0470378291437879 no 3210 0.0396363662590701 4626 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2202 7226349 200 µM -1.75516755401834 0.0470139619200163 no 3211 0.0396153259926973 4630 844334 SGTC_2974 9094440 9.66 µM -1.75561736977376 0.0469703512689288 no 3212 0.0395768821631476 4580 25236134 SGTC_1720 st037298 9.481 µM -1.75705349549172 0.0468313327331025 no 3213 0.0394543456731592 4589 597396 SGTC_1881 5652484 16 µM -1.75745978156823 0.0467920637467026 no 3214 0.0394197356416603 4594 2255129 SGTC_2833 9001315 45.46 µM -1.76179618246237 0.0463745787310821 no 3215 0.0390518699925004 4547 2989378 SGTC_1859 st055998 20 µM -1.76560802172697 0.0460100701035338 no 3216 0.0387308166483727 4550 676301 SGTC_3062 9077494 49.47 µM -1.76823213484114 0.0457604785502522 no 3217 0.0385110520313879 4543 16459633 SGTC_897 1000-0139 31.4 µM -1.76872755224907 0.0457134794497786 no 3218 0.0384696760039544 4582 6151020 SGTC_2234 tolnaftate 200 µM -1.77640401807192 0.0449901776115542 no 3219 0.0378331746560797 4717 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2078 5212016 200 µM -1.77888560420539 0.0447583345317883 no 3220 0.0376292593607939 4533 1899708 SGTC_515 4092-1064 102 µM -1.78270357550823 0.0444035188626836 no 3221 0.0373172845069587 4583 717353 SGTC_625 k213-0058 121 µM -1.7836381127065 0.0443170156692827 no 3222 0.0372412441776672 4669 3655420 SGTC_2719 novobiocin 32.65 µM -1.79082695453132 0.0436561296899683 no 3223 0.0366605341831941 4648 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_966 1300-0360 30.2 µM -1.79336050683041 0.043425118740528 no 3224 0.0364576490938861 4610 70588 SGTC_2287 7945887 168.79 µM -1.79390614714257 0.0433754962821314 no 3225 0.0364140750683528 4636 1245853 SGTC_550 4123-0385 25.7 µM -1.79751226504249 0.043048693232254 no 3226 0.0361271663833414 4643 5731123 SGTC_1286 0929-0070 131 µM -1.80386243687336 0.0424780489405772 no 3227 0.0356264374426489 4664 1420408 SGTC_605 1315-0399 119 µM -1.80491690644886 0.0423838863080546 no 3228 0.0355438428945136 4681 24020461 SGTC_3203 9113543 49.47 µM -1.80974345022257 0.0419550358242977 no 3229 0.0351677905320199 4622 17018012 SGTC_2442 5158906 48.48 µM -1.81047717307258 0.0418901513882546 no 3230 0.0351109105643869 4632 1893835 SGTC_532 1548-0774 215 µM -1.81198922412025 0.0417566942219032 no 3231 0.0349939307782214 4669 5932993 SGTC_123 0083-0120 66.675 µM -1.82581821485927 0.0405520262253293 no 3232 0.0339388243336025 4611 16001701 SGTC_1439 4092-1168 46 µM -1.83927069885572 0.0394073790540712 no 3233 0.0329376902630367 4661 2886240 SGTC_2206 7254556 146.969 µM -1.84550945875402 0.0388855290646401 no 3234 0.0324817319183172 4659 4398905 SGTC_91 0417-1751 58.384 µM -1.84790257628218 0.0386868527441377 no 3235 0.0323082188905767 4694 6795624 SGTC_2242 6630449 61.2675 µM -1.85310037983934 0.0382581801146403 no 3236 0.03193398620487 4640 691249 YDR170C SEC7 SGTC_1459 k035-0031 35.7 µM -1.8576226590682 0.0378883773421239 no 3237 0.0316113092238833 4422 3877128 YMR208W ERG12 SGTC_1347 1493-0251 600 nM -1.85884540848586 0.0377888912959657 no 3238 0.0315245269849078 4677 3986378 SGTC_650 1328-0195 38 µM -1.86333922054739 0.0374250932761434 no 3239 0.0312072776943953 4644 2780821 SGTC_306 1672-3436 11.6 µM -1.86528653787427 0.0372683383962359 no 3240 0.0310706255538445 4650 6797378 SGTC_472 calcifediol 10 µM -1.8735278513183 0.0366108587502199 no 3241 0.0304977652404833 4680 5283731 A vitamin D metabolite. SGTC_2001 4023502 57.655 µM -1.87602616156951 0.0364134319769233 no 3242 0.0303258438067778 4619 108941 YCR052W RSC6 SGTC_601 0986-0029 62.9 µM -1.88419405796551 0.035774043854061 no 3243 0.0297693655068199 4615 24747981 SGTC_530 4358-1714 28 µM -1.89027976373106 0.0353036560597803 no 3244 0.0293602768799521 4655 1564641 SGTC_1427 4048-4900 550 nM -1.89055059783642 0.0352828407135528 no 3245 0.0293421801153164 4644 24132586 SGTC_364 0083-0097 67.7 µM -1.89890390433068 0.0346457627542637 no 3246 0.0287885559549081 4653 5207356 SGTC_316 k060-0003 58.6 µM -1.90094137241216 0.0344918137414933 no 3247 0.0286548461145404 4692 6152314 SGTC_696 1560-0013 611 µM -1.90265403778487 0.03436284165684 no 3248 0.0285428515135665 4662 1650269 SGTC_549 1661-1316 519 µM -1.90794418737207 0.033966968044751 no 3249 0.0281992151617723 4683 2857282 SGTC_2171 5739187 198.077 µM -1.9165236535903 0.0333329270897036 no 3250 0.0276492376941252 4628 2262761 SGTC_744 1594-0068 283 µM -1.93906252689815 0.0317135689963659 no 3251 0.026246862476647 4665 668392 SGTC_284 0988-0104 32.6 µM -1.94076846446752 0.031593694852241 no 3252 0.0261431838621437 4646 4666532 SGTC_1082 camptothecin 424.86 nM -1.94452104288613 0.0313313233571976 no 3253 0.0259163251895647 4553 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2956 9076196 2.52 µM -1.95180503418183 0.0308271861981797 no 3254 0.0254806781906519 4655 16423868 SGTC_3005 9076496 71.4286 µM -1.95445548616863 0.0306454182905557 no 3255 0.0253236871324561 4650 21368410 SGTC_3015 9080845 49.47 µM -1.98235824027309 0.028785160434004 no 3256 0.0237195799617295 4699 5296973 SGTC_3196 9111891 49.47 µM -1.98871339354093 0.0283748589440668 no 3257 0.0233664233989727 4652 18891510 SGTC_1819 st053448 58.6 µM -1.99568476606062 0.0279303824000825 no 3258 0.0229841231490351 4653 2857616 SGTC_907 3448-6986 75.5 µM -2.00382852456597 0.0274185172413824 no 3259 0.0225442160706162 4683 590582 SGTC_2404 5161160 200 µM -2.01045985101442 0.0270075138311775 no 3260 0.0221912707126839 4656 2831543 SGTC_1349 flufenamic acid 69 µM -2.0109187751649 0.0269792614053005 no 3261 0.0221670184314729 4632 3371 A non-steroidal anti-inflammatory. SGTC_2214 7179297 48.276 µM -2.0167159959051 0.0266244903186819 no 3262 0.0218625798349862 4742 769744 SGTC_947 3447-0010 211 µM -2.01806413257569 0.0265425495957613 no 3263 0.0217922912761664 4643 748350 SGTC_3274 9138298 49.47 µM -2.01993186234529 0.0264293758747389 no 3264 0.0216952278733321 4657 17015756 SGTC_738 1315-0003 72.4 µM -2.02258903149074 0.0262690618542559 no 3265 0.021557767994884 4688 6251474 SGTC_3337 9144342 33.5465 µM -2.02475517257632 0.0261389750716203 no 3266 0.0214462550986428 4678 17682949 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.04231749978589 0.0251040382405631 no 3267 0.0205600236628317 4634 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2197 6588183 93.1375 µM -2.04828366640083 0.0247603656288425 no 3268 0.0202661062431458 4719 884136 SGTC_714 4296-0578 26.1 µM -2.04974092070467 0.0246770248862309 no 3269 0.020194859764846 4723 1589775 SGTC_1168 k815-0004 80.5 µM -2.05660655588404 0.0242875374130818 no 3270 0.0198620435532125 4688 642433 SGTC_3206 9114350 49.47 µM -2.05869552454892 0.0241700594882422 no 3271 0.0197617076173538 4587 17087243 SGTC_2271 7849410 118.62 µM -2.05986904222978 0.0241042736757502 no 3272 0.0197055309795316 4649 972430 SGTC_137 0438-0332 85.389 µM -2.06612134866406 0.0237563083707462 no 3273 0.0194085114519697 4643 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_171 k064-0041 9.68 µM -2.09831194705356 0.0220309368229524 no 3274 0.0179387989207613 4680 53325 SGTC_313 3474-0040 5.03 µM -2.09852853468657 0.0220196962062547 no 3275 0.0179292409737452 4705 1043375 YIL048W NEO1 SGTC_832 4083-0019 164 µM -2.1041422708012 0.0217300352105473 no 3276 0.0176830192452552 4732 1990758 SGTC_2684 capsaicin 100 µM -2.12346950928909 0.0207572761949539 no 3277 0.0168572639517722 4741 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_850 0388-0143 75.9 µM -2.14679625507798 0.0196325667735349 no 3278 0.0159047528082624 4733 67273 SGTC_3169 9102970 49.47 µM -2.14830221590227 0.0195617694127009 no 3279 0.0158448774916491 4755 17027839 SGTC_244 nsc-207895 1.295 µM -2.15449378448693 0.019272968871902 no 3280 0.0156007344414406 4632 42640 SGTC_1781 st038725 66.3 µM -2.16045591429973 0.0189983030399534 no 3281 0.0153686964616354 4701 4270275 YIL048W NEO1 SGTC_2356 9061756 188.97 µM -2.17242909051249 0.0184567631535732 no 3282 0.0149116563853178 4735 20104043 SGTC_2043 5101342 149 µM -2.17590280956853 0.0183021307192036 no 3283 0.0147812643427243 4726 678451 SGTC_2279 7948423 32.93 µM -2.18345324520979 0.0179698268330939 no 3284 0.0145012242540797 4678 1247112 SGTC_632 0781-2353 4.65 µM -2.18580405445375 0.0178674208625523 no 3285 0.0144149720100212 4741 6811515 YHR007C ERG11 SGTC_963 1269-2853 151 µM -2.189104585247 0.0177244834159996 no 3286 0.0142946196751142 4711 3668223 SGTC_1321 1326-2144 215 µM -2.18917306412849 0.0177215281345285 no 3287 0.0142921318161944 4712 3513030 SGTC_365 0121-0052 13.6 µM -2.20340616385564 0.0171163394229954 no 3288 0.0137830670731323 4686 3101739 SGTC_1821 st053465 65.6 µM -2.21037041234268 0.016826713932498 no 3289 0.0135397327502611 4737 675086 SGTC_1431 4049-0260 9.09 µM -2.2114528477377 0.0167820766752867 no 3290 0.0135022468332713 4751 3854841 SGTC_131 0141-0277 33.849 µM -2.21145705933052 0.0167819031964561 no 3291 0.0135021011563709 4683 1547771 SGTC_2244 6635614 200 µM -2.2216715173917 0.0163656498028401 no 3292 0.0131527563883063 4705 836499 SGTC_1730 st033808 45.1 µM -2.22584614461762 0.0161980906018772 no 3293 0.0130122443722891 4673 1045166 SGTC_1469 k284-2957 126 µM -2.22612275785456 0.0161870401384349 no 3294 0.0130029799790798 4744 23884841 SGTC_820 1582-0060 59.9 µM -2.24315245096545 0.0155190441501243 no 3295 0.0124434926588483 4739 3848840 SGTC_1009 4106-0057 9.87 µM -2.25106645154328 0.0152167557685917 no 3296 0.0121906644386726 4718 2928005 SGTC_1173 0443-0020 122 µM -2.26665882892439 0.0146359561651967 no 3297 0.0117055376605983 4730 5331295 SGTC_2961 9083290 32.55 µM -2.27729961535729 0.0142506377863677 no 3298 0.0113841699506082 4708 17741490 SGTC_1356 1502-0781 85.8 µM -2.28581416382676 0.0139486377301288 no 3299 0.0111325663553743 4751 567702 SGTC_2222 6885208 172.143 µM -2.2867537224699 0.0139156532827077 no 3300 0.0111051010187183 4765 609514 SGTC_729 4092-0585 94.1 µM -2.2875948568208 0.0138861812245471 no 3301 0.0110805628484697 4735 2169061 SGTC_215 1287-0124 461.5 µM -2.29127597786067 0.0137578327387963 no 3302 0.0109737285297027 4762 5560863 SGTC_2521 angolensin 13.4 µM -2.29348754985249 0.0136812156788648 no 3303 0.0109099756657053 4743 821428 A flavenoid. SGTC_647 0140-0236 81 µM -2.29396941255919 0.0136645710965085 no 3304 0.0108961278768855 4749 990837 SGTC_830 4076-0286 57.8 µM -2.29479361278576 0.0136361419344854 no 3305 0.0108724774345434 4760 6866659 SGTC_526 4469-0568 170 µM -2.31153202277128 0.0130697290008464 no 3306 0.0104017432406104 4716 2901964 SGTC_781 4335-2806 94.4 µM -2.3162367128191 0.0129142344030497 no 3307 0.010272673843574 4750 845254 SGTC_2018 5133068 143 µM -2.32523536365201 0.012621272481736 no 3308 0.0100296891814737 4721 785362 SGTC_1594 piperine 70.1 µM -2.33532833298037 0.0122995443174997 no 3309 0.00976313757272445 4736 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1911 st060208 74.3 µM -2.33764686260815 0.0122266494602712 no 3310 0.00970278740052696 4739 688783 SGTC_1018 4259-0013 28.1 µM -2.34701737779845 0.0119358405320516 no 3311 0.00946218606434143 4758 6801262 SGTC_1076 itraconazole 331 nM -2.35429926829254 0.011714011866805 no 3312 0.00927883183147058 4758 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2280 7785178 200 µM -2.35488870029918 0.0116962135293472 no 3313 0.0092641271708917 4737 2954328 SGTC_1466 k213-0079 57.5 µM -2.36381639786954 0.0114294915924911 no 3314 0.00904388709256878 4762 3657981 SGTC_2448 5185112 27.17 µM -2.37014285277055 0.0112436974140189 no 3315 0.0088906068065756 4740 5718189 SGTC_1057 3448-5381 134 µM -2.37101428251323 0.0112183122651678 no 3316 0.00886967278869766 4728 5497911 SGTC_1568 digitonin 820 nM -2.3886445034067 0.0107153312879596 no 3317 0.00845532831156658 4719 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1847 st056231 15 µM -2.41354014097028 0.010038561639904 no 3318 0.00789919378481662 4745 5393180 SGTC_1627 st003713 25.6 µM -2.42514391152818 0.00973607758488152 no 3319 0.00765115970709698 4737 16195070 YER133W GLC7 SGTC_2987 9018338 71.43 µM -2.43085702962861 0.00959009697590878 no 3320 0.00753157855806036 4749 5055682 SGTC_1957 st077035 62.4 µM -2.43345131308699 0.00952444237167238 no 3321 0.00747782329809086 4750 705593 SGTC_2069 5228469 200 µM -2.44663318042454 0.00919687940953999 no 3322 0.00720987562098675 4739 2835210 SGTC_1646 st011709 75.6 µM -2.46133015580598 0.00884333170961485 no 3323 0.0069211460106414 4743 5757843 SGTC_1905 st060207 84.5 µM -2.46731537728877 0.00870280101206066 no 3324 0.00680652004975406 4750 1948547 SGTC_2276 7947513 42.08 µM -2.53329160168672 0.00727880770401257 no 3325 0.0056498454158757 4720 2105100 SGTC_633 0437-0093 97.7 µM -2.53620230629106 0.00722101452253249 no 3326 0.00560309875704134 4731 2831118 SGTC_1645 Cervolide 78 µM -2.54179707750082 0.00711106364729261 no 3327 0.00551420902990676 4782 23173 A fragrance. SGTC_750 4073-0104 132 µM -2.54664151709011 0.00701705459146487 no 3328 0.00543825504067769 4550 22330957 SGTC_1860 st056228 74.6 µM -2.56038323841677 0.00675633128435394 no 3329 0.00522783957039679 4758 688679 SGTC_2979 9012552 45.46 µM -2.57705776422931 0.00645148547465805 no 3330 0.00498226485321205 4764 17100905 SGTC_2095 5432005 200 µM -2.60443851645789 0.00597725040286392 no 3331 0.00460124652058366 4766 783734 SGTC_741 4582-0002 126 µM -2.60515784526548 0.00596521958256882 no 3332 0.00459159714337263 4779 2912688 SGTC_2228 7354201 200 µM -2.61393848340352 0.00582008414037902 no 3333 0.00447525752197357 4787 753451 SGTC_1127 asiatic acid 681.4 nM -2.63850766402787 0.00543049005725315 no 3334 0.00416359090563679 4742 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_308 4092-1169 104 µM -2.66951541123658 0.00497198630757293 no 3335 0.00379803935611116 4752 2268590 YDL196W YDL196W SGTC_1025 k007-0731 70 µM -2.67137221211597 0.00494565807000111 no 3336 0.00377709147291551 4765 6256118 SGTC_1425 4048-4433 7.33 µM -2.67456002147674 0.00490074656029691 no 3337 0.00374136902169105 4791 23734946 SGTC_330 1488-0319 80.1 µM -2.7000322680861 0.00455473955691192 no 3338 0.00346663755406677 4791 6846614 SGTC_719 2810-4230 27.3 µM -2.71687248179577 0.00433813012383423 no 3339 0.00329509966421171 4783 721079 SGTC_311 1315-0136 58 µM -2.7302582350571 0.00417257200996645 no 3340 0.00316423659807662 4784 6759207 SGTC_2626 ethyl orsellinate 100 µM -2.73132421126181 0.0041596339634332 no 3341 0.0031540191413347 4741 75653 A natural product. SGTC_636 0kpi-0074 126 µM -2.76112166695445 0.00381219583633672 no 3342 0.00288016064636999 4789 616434 SGTC_2047 4141938 200 µM -2.78188746210193 0.0035856884871399 no 3343 0.002702188834372 4791 3807862 SGTC_1856 st057054 55.7 µM -2.79038644696239 0.00349652201000001 no 3344 0.00263225816859077 4768 1266018 SGTC_626 0214-0009 33 µM -2.82867498928549 0.00311902235474606 no 3345 0.0023370570081255 4787 3437874 SGTC_980 1473-0395 201 µM -2.87043481295137 0.00274947835085493 no 3346 0.00204953852508745 4769 768876 SGTC_962 1254-0300 21.5 µM -2.89607362560232 0.0025426546910403 no 3347 0.00188931867892519 4785 7340576 SGTC_2007 4011539 71.82 µM -3.44364780364201 0.000415126409113937 yes 3348 0.0002869613982091 4791 45595301 SGTC_3192 9110362 49.47 µM -3.46922272839641 0.000378891990290488 yes 3349 0.000260983267626596 4800 16649480 SGTC_3198 9112019 49.47 µM -3.68236933720588 0.000172897879616804 yes 3350 0.00011553815486893 4803 45595555 SGTC_620 0109-0052 432 µM -3.79473565110807 0.000112421371308779 yes 3351 7.39004227986542e-05 4804 493037 SGTC_2005 4024620 188 µM -4.04684972460074 4.10156473276533e-05 yes 3352 2.59557719058355e-05 4803 236743 SGTC_1857 st056007 79.3 µM -4.15787933067238 2.58210056322636e-05 yes 3353 1.60607806001762e-05 4803 619834 SGTC_58 0957-0393 9 µM -4.3226613614989 1.2720559660097e-05 yes 3354 7.70791288242031e-06 4653 6997992 SGTC_78 0336-0123 156.75 µM -4.36513266704359 1.05554155859946e-05 yes 3355 6.3522814386436e-06 4800 6765896 SGTC_1852 st056254 31.4 µM -4.92629455117999 7.6546169269251e-07 yes 3356 4.19018193158866e-07 4809 442583