SGTCid condition conc unit RRP6|YOR001W.score RRP6|YOR001W.strain.pval RRP6|YOR001W.strain.significant RRP6|YOR001W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3337 9144342 33.5465 µM 8.3905482451127 4.37331615482088e-22 yes 1 2.41940155181089e-17 8 17682949
SGTC_3148 9097893 49.47 µM 7.49317867616541 4.69939531867087e-18 yes 2 3.36126422050268e-14 7 17174100
SGTC_2932 9016711 44.54 µM 7.1892932294379 8.67043427281892e-17 yes 3 3.25637840363329e-13 10 7117328
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 6.53090546655255 3.22995515013522e-14 yes 4 3.26866266529524e-11 27 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 5.85719100945782 7.89783695030381e-12 yes 5 2.35380790139102e-09 18 91467 include heat shock
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 4.96377623911032 4.86999497211093e-09 yes 6 3.45677956374919e-07 19 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_582 0987-0078 156 µM 4.61314825012063 4.62950023635554e-08 yes 7 1.98307600210721e-06 42 1625765
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 4.40756467405827 1.61599882155285e-07 yes 8 5.22696954012756e-06 28 368090
SGTC_2603 homopterocarpin 100 µM 4.23826572757682 4.35140109798437e-07 yes 9 1.12626533176675e-05 25 101795 A weak amylase inhibitor.
SGTC_2933 9026794 32.47 µM 4.16491844149768 6.61111153873757e-07 yes 10 1.5573194336195e-05 12 17586027
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 4.15743826751033 6.89665837519336e-07 yes 11 1.60918102012658e-05 46 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 4.12810278697654 8.13527671556668e-07 yes 12 1.82884308210549e-05 32 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_101 0490-5701 117.494 µM 4.1193257812326 8.5456651436839e-07 yes 13 1.89991298026958e-05 11 4661669
SGTC_1792 st045773 43.6 µM 3.9074262349916 2.72501006173651e-06 yes 14 4.66422538180022e-05 27 2919270
SGTC_1137 ixabepilone 100 µM 3.78867513851913 5.09586576616533e-06 yes 15 7.57264025619685e-05 32 154225 A novel microtubule stabilizer.
SGTC_3240 9133527 49.47 µM 3.63774947266084 1.10150152580684e-05 yes 16 0.000137515375186546 17 17617455
SGTC_667 1498-1044 59 µM 3.56285833912635 1.59826137743871e-05 yes 17 0.000183419329889999 29 6739982
SGTC_2325 6158266 200 µM 3.44639392425481 2.8131754776068e-05 yes 18 0.000284060776740146 43 3623240
SGTC_2057 5236571 38.335 µM 3.24167031393972 7.30463935544093e-05 yes 19 0.000594157026751493 70 54684039 YBR257W POP4
SGTC_2881 9058953 51.95 µM 3.21586347277169 8.20884630637354e-05 yes 20 0.000650263436102252 51 17122249
SGTC_598 3937-0236 20.2 µM 3.20240430942845 8.72122278170874e-05 yes 21 0.000681427851955453 61 1379313
SGTC_3342 9147791 14.508 µM 3.16569419246362 0.000102758561974467 yes 22 0.000773566763355533 43 1838168
SGTC_1119 parthenolide 318.541 nM 3.0838327527024 0.000147283022011496 yes 23 0.00102176220172652 87 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_401 neomycin 50 µM 3.06708448665015 0.000158382803577274 yes 24 0.00108078875953468 36 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3046 9092212 49.47 µM 3.06537812051044 0.000159556609510077 yes 25 0.00108697480860317 27 25236637
SGTC_118 0083-0097 135.343 µM 3.06159743593322 0.000162186404865827 yes 26 0.00110079662378429 252 5207356
SGTC_2688 kanamycin b 96.69 µM 3.04201616805254 0.00017646831851755 yes 27 0.00117499635796217 527 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1374 2889-5571 141 µM 3.03721560264771 0.000180144938993182 yes 28 0.00119387301338342 94 2853281
SGTC_1497 4476-2978 41.3 µM 2.99749996174993 0.000213428063294934 yes 29 0.00136101946449308 64 1528379
SGTC_2489 cantharidin 73.42 µM 2.98387602443786 0.000226110442671877 yes 30 0.00142311034892221 102 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1958 st076513 41.9 µM 2.95414331557587 0.000256269489961554 yes 31 0.00156769181357433 95 732122 YGL099W LSG1
SGTC_1683 st010134 710 nM 2.88786490396054 0.000337490338060893 yes 32 0.0019393321059175 90 3818134
SGTC_364 0083-0097 67.7 µM 2.86006088627874 0.000378218175934901 yes 33 0.00211779839664433 83 5207356
SGTC_1380 2291-0730 164 µM 2.85594802484286 0.000384616466172855 yes 34 0.00214542684732093 74 2999191
SGTC_3095 9117207 49.47 µM 2.84900247379857 0.00039565012370404 yes 35 0.00219282697316299 34 17015229
SGTC_679 0422-0091 41.4 µM 2.77808438567477 0.000526389313239032 yes 36 0.00273402077657123 102 627384 YHR062C RPP1
SGTC_2112 5488546 200 µM 2.71578374088794 0.000673126742762079 yes 37 0.00330595459855408 85 600757
SGTC_1372 2752-0194 270 µM 2.68157315071394 0.000768932120099412 yes 38 0.00366384459482138 71 823334
SGTC_2853 9015042 58.44 µM 2.63274518699929 0.000927535688353256 yes 39 0.00423489324006537 96 6457456
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.62029319877749 0.000972532611712188 yes 40 0.00439270984403433 94 6312947
SGTC_2086 5274770 176.623 µM 2.58073993751281 0.00112908900474315 no 41 0.00492944096901894 117 689278
SGTC_2652 actinonin 100 µM 2.57851443701352 0.00113854906648942 no 42 0.00496130766763153 54 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3350 9150499 3.57 µM 2.57518166618704 0.00115285171048932 no 43 0.00500937248460347 153 4910996 YPR165W RHO1
SGTC_1098 clofazimine 15.1 µM 2.56907183418624 0.00117950031033644 no 44 0.00509856585806123 129 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1232 0279-0259 161 µM 2.55745816650028 0.00123171509621677 no 45 0.00527201197262758 113 1560000
SGTC_322 k048-0136 19.3 µM 2.54316428148135 0.00129888073694729 no 46 0.00549267830602472 86 6823282
SGTC_59 0330-0160 1.33 µM 2.50782258246439 0.00147956671673584 no 47 0.00607388218733136 278 4293482
SGTC_2428 5615643 7.78 µM 2.49087826659336 0.00157408495572854 no 48 0.00637138856695793 113 2253075
SGTC_1399 3562-5772 25 µM 2.47448535280595 0.00167073362013261 no 49 0.00667141459572174 85 23847490
SGTC_1053 3366-3204 134 µM 2.46629013688454 0.00172104966563663 no 50 0.006826035103859 132 3632071 YPR165W RHO1
SGTC_3245 9134821 49.47 µM 2.46134948019479 0.00175204627746017 no 51 0.00692077319357431 127 17014901
SGTC_1208 2323-2347 50.3 µM 2.45500997510829 0.00179256286942613 no 52 0.00704403395298385 99 5412760
SGTC_1761 st044296 37 µM 2.45265240857427 0.00180784650240488 no 53 0.00709036462049275 98 1826700
SGTC_1178 0988-0033 191 µM 2.43729175360515 0.00191036261635043 no 54 0.00739886738759622 168 5392207
SGTC_2461 5755302 26.15 µM 2.4190348292974 0.00203906213005822 no 55 0.00778087505373019 149 2788904
SGTC_2097 5376186 200 µM 2.40698232471561 0.00212828487440991 no 56 0.00804247416594306 139 742755
SGTC_3066 9117245 49.47 µM 2.39228629145701 0.00224186056527554 no 57 0.00837188798483569 125 17176980
SGTC_782 0083-0095 30.5 µM 2.37171414249654 0.0024100781754631 no 58 0.0088528916134333 166 3591729 An indicator and reagent.
SGTC_2420 aureobasidin a 50 nM 2.34602064035686 0.00263617634209941 no 59 0.00948752832312998 181 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_864 0469-0573 172 µM 2.33309426947809 0.00275702180528761 no 60 0.00982159908320047 125 689425
SGTC_1155 4088-0394 48.2 µM 2.30759303134337 0.00301019117154672 no 61 0.0105108912365563 154 2326248
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.29193044380541 0.00317588348870119 no 62 0.0109548285952067 135 4213774
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.27554401576762 0.003357976448575 no 63 0.011436657688942 141 16623 A steroid.
SGTC_1985 st071382 65.5 µM 2.26619863176771 0.00346597864503963 no 64 0.0117196121923809 152 6123237
SGTC_2591 skatole 100 µM 2.23995738745409 0.00378611839841387 no 65 0.0125468447165238 167 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_140 0062-0056 502.533 µM 2.23050166453912 0.00390782010564851 no 66 0.0128570785374445 176 3758964
SGTC_2502 avocadyne acetate 18.59 µM 2.22399752362186 0.00399355552089508 no 67 0.0130743054284791 198 3952079
SGTC_664 1222-0054 14.9 µM 2.22159595735651 0.00402563548860161 no 68 0.0131553116655923 184 6813991
SGTC_3026 9090633 49.47 µM 2.17279585357777 0.00472946171444403 no 69 0.0148978427654598 172 25236842
SGTC_812 4251-0442 148 µM 2.16739298843254 0.00481377163168013 no 70 0.0151024507247828 134 5723007
SGTC_861 0443-0273 110 µM 2.15211893975922 0.00505941193368119 no 71 0.0156939939025834 160 6149169
SGTC_691 1548-0686 185 µM 2.14198230551486 0.00522853278043493 no 72 0.016097452965194 224 46495133
SGTC_1161 k007-0610 110 µM 2.12938114713845 0.00544577296708432 no 73 0.0166113694816855 320 5843850
SGTC_132 0417-1715 25.805 µM 2.12649781223668 0.00549659458972168 no 74 0.0167309156125908 172 6769098
SGTC_1245 0418-0076 17.2 µM 2.12262076839711 0.00556559546372989 no 75 0.0168928215970084 201 6790114
SGTC_444 curcumin 90.4 µM 2.10204769249253 0.00594477040578246 no 76 0.0177745491154355 196 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1154 4088-0362 150 µM 2.09104497395546 0.00615681574835805 no 77 0.0182620163082562 249 6618304
SGTC_1757 st041620 31.8375 µM 2.08275156334373 0.00632104830669649 no 78 0.0186369373567843 196 5289815
SGTC_1522 st012842 45.6 µM 2.08034801142724 0.00636936458801131 no 79 0.018746812031756 198 3491067 YOR116C RPO31
SGTC_865 0488-0499 301 µM 2.02136636327983 0.00766200447203162 no 80 0.0216209270078991 196 9634651
SGTC_2295 7971645 200 µM 2.0143890720434 0.00782925200620487 no 81 0.0219843503918221 220 2978226 YKL099C UTP11
SGTC_1870 st057514 26.5 µM 2.00266140065287 0.00811761054482326 no 82 0.0226068222668912 225 5393161
SGTC_1671 st016596 74.5 µM 1.99636540537078 0.00827623329238561 no 83 0.0229470817577227 222 2829167
SGTC_2195 6536160 144.242 µM 1.98776563680979 0.00849729356635425 no 84 0.0234188079253241 183 3834386
SGTC_387 norethindrone acetate 66.7 µM 1.98388137196133 0.0085988273105013 no 85 0.0236345330095064 198 541197
SGTC_3269 9137823 49.47 µM 1.97069620970915 0.00895146494660467 no 86 0.0243793171756905 199 17682936
SGTC_449 xestospongin c 11.1929 µM 1.96065091696099 0.00922856750627759 no 87 0.0249598792044976 291 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_458 nppb 133 µM 1.96033858005916 0.00923730245490099 no 88 0.0249781147742302 189 4549 A chloride channel blocker.
SGTC_485 niflumic acid 177 µM 1.95724778681696 0.00932413173373296 no 89 0.0251591714807481 199 4488 A COX2 inhibitor.
SGTC_2775 cyproheptadine 69.59 µM 1.95473812147283 0.00939515993459555 no 90 0.0253069940479493 212 2913 A selective serotonin reuptake inhibitor.
SGTC_1806 st050005 60.3 µM 1.95167527348508 0.00948248512073871 no 91 0.0254883850334909 240 5194765
SGTC_3255 9139072 49.47 µM 1.95098450469864 0.00950227750547735 no 92 0.0255294445450275 215 17646060
SGTC_358 0075-0058 9.45 µM 1.9441231171053 0.00970084427661594 no 93 0.0259403030954286 344 1069125
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.93479639846948 0.00997656570465281 no 94 0.0265076426189099 229 7104
SGTC_194 1486-1323 56.904 µM 1.93235821505084 0.0100497629333118 no 95 0.0266576538379671 219 5178754
SGTC_1817 st052116 64.4 µM 1.92270284407969 0.0103442512298083 no 96 0.0272586897340431 222 4361398
SGTC_2505 galangin 7.89 µM 1.91084556522938 0.0107161678540442 no 97 0.0280122150855737 175 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2384 9036245 200 µM 1.8994336265791 0.0110850577231711 no 98 0.0287537428704245 242 6462766
SGTC_1052 3253-3998 198 µM 1.89316169943364 0.0112924623528284 no 99 0.0291681845460209 298 5450317
SGTC_2803 7707263 71.43 µM 1.88957578475697 0.0114125528957885 no 100 0.0294073591507197 234 2199229
SGTC_1092 toremifene 6.32 µM 1.88091006792597 0.0117073537547318 no 101 0.0299920767174613 303 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2171 5739187 198.077 µM 1.87881313638921 0.0117796751233257 no 102 0.0301350063589457 210 2262761
SGTC_700 3453-2283 142 µM 1.8643693328572 0.0122884424977536 no 103 0.0311349282113597 304 565664
SGTC_2193 5925765 200 µM 1.85965983498359 0.0124583947846382 no 104 0.0314668340015372 195 877370
SGTC_1615 st002656 86.5 µM 1.85609165690186 0.0125885118499093 no 105 0.0317202473710454 239 1584458
SGTC_726 3448-4391 34.2 µM 1.85401060996338 0.0126649410366163 no 106 0.0318688210419145 291 1356692
SGTC_1271 0832-2808 169 µM 1.83828474362952 0.0132555860285885 no 107 0.033010229002256 259 3663794
SGTC_1965 Pectolinarigenin 58.4 µM 1.83585576551704 0.013348905244368 no 108 0.033189495660561 242 5320438 An anti-inflammatory.
SGTC_3027 9089541 49.47 µM 1.82692221146336 0.0136970218470566 no 109 0.0338557330622497 284 9943819
SGTC_1014 4130-3005 69.3 µM 1.82517398064075 0.0137660544721485 no 110 0.0339873894672615 311 743608
SGTC_2139 5578692 56.4705 µM 1.81891647488339 0.0140156105982826 no 111 0.0344620869814867 232 650991 YMR113W FOL3
SGTC_2029 5175081 200 µM 1.81043820406582 0.0143599477840827 no 112 0.0351139296366225 315 1380876
SGTC_3282 9108498 15.4605 µM 1.8086113967182 0.0144350884645492 no 113 0.0352556983406714 296 16459645
SGTC_3248 9135562 49.47 µM 1.80189651859538 0.014714202445753 no 114 0.0357808440384733 280 17650701
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.79141401203943 0.0151592018867851 no 115 0.036613441012707 307 5106787 A p450 inhibitor.
SGTC_2841 9004761 38.96 µM 1.77831241681531 0.0157316013542904 no 116 0.0376762790753723 283 2991039
SGTC_2713 st079149 53.4 µM 1.77716911880487 0.0157824194685675 no 117 0.0377702093569783 306 3103253
SGTC_439 amiodarone 34.4 µM 1.7725834381979 0.0159876643478124 no 118 0.0381488790355377 376 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1737 st035557 69.7 µM 1.77101828203543 0.0160582390290053 no 119 0.0382788308109834 236 5716916
SGTC_98 0074-0023 107.663 µM 1.77055430214726 0.0160792116520319 no 120 0.0383174234147803 322 3563821
SGTC_2883 9059145 45.46 µM 1.7624234326482 0.0164505675068153 no 121 0.0389988912103889 249 16476510
SGTC_563 tetrahydrosecaminediol 614 µM 1.75757801201021 0.0166753421997635 no 122 0.0394096686617722 312 334274 A psychoactive constituent of the cannabis plant.
SGTC_1461 k072-0203 53.8 µM 1.75165516386914 0.0169536623863558 no 123 0.0399165604457067 288 5418714
SGTC_3097 9117246 49.47 µM 1.74791600819322 0.0171314062508783 no 124 0.0402392862240437 309 16423892
SGTC_2726 cimetidine 79.27 µM 1.7393125952705 0.0175464330738102 no 125 0.0409898965153134 221 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_930 2810-3379 265 µM 1.7311701071913 0.0179471004068325 no 126 0.041710714618907 344 1015764
SGTC_87 0100-0052 35.5 µM 1.72807668200041 0.0181013505144836 no 127 0.0419872387109469 556 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_552 k242-0005 476 µM 1.7275795834488 0.0181262428557111 no 128 0.0420318128905426 267 4088318
SGTC_2987 9018338 71.43 µM 1.72443180547902 0.0182845469745826 no 129 0.0423149599851941 328 5055682
SGTC_655 k060-0012 42 µM 1.71630004857703 0.0186989606057575 no 130 0.043053569721865 321 5994525
SGTC_1500 4488-1866 171 µM 1.71601724654939 0.0187135155517789 no 131 0.0430794429384601 336 2900003
SGTC_625 k213-0058 121 µM 1.69987341205591 0.01956052550204 no 132 0.0445773695189781 513 3655420
SGTC_1932 st074806 40.9 µM 1.6950758969559 0.0198184253394615 no 133 0.0450305119734554 362 17251235
SGTC_3114 9122766 49.47 µM 1.69350164634606 0.0199036786916567 no 134 0.0451800108792706 315 17176985
SGTC_708 3448-5400 146 µM 1.69159787133782 0.02000719292453 no 135 0.0453613363225189 355 3462195
SGTC_1594 piperine 70.1 µM 1.66788684006534 0.0213351641305714 no 136 0.0476690962806229 366 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_748 act1.228 77.9 µM 1.66538730422931 0.0214794006633249 no 137 0.0479177553334637 406 4421505 YNR035C ARC35
SGTC_2007 4011539 71.82 µM 1.65034464940008 0.0223649560828591 no 138 0.0494362325091148 377 45595301
SGTC_956 1185-0240 191 µM 1.64875968236532 0.0224600308282797 no 139 0.0495984388705792 341 1416193
SGTC_2140 5586273 200 µM 1.64056012422117 0.0229573433026484 no 140 0.0504443790870707 295 854421
SGTC_2113 5491891 107.031 µM 1.64018948178321 0.0229800405779454 no 141 0.0504828878008688 365 789979
SGTC_2094 5332512 191.667 µM 1.63398329437657 0.0233629096511239 no 142 0.0511311791993143 364 755774
SGTC_175 3793-3120 23.7 µM 1.62893829190985 0.0236780860132466 no 143 0.0516630414300068 340 5322297
SGTC_2030 5175110 200 µM 1.62791951058049 0.0237421643450241 no 144 0.0517709769068388 342 2831986
SGTC_108 0509-0257 621.132 µM 1.62604796556456 0.0238602589507158 no 145 0.0519697260108995 409 536624
SGTC_2290 7904846 200 µM 1.62122472225091 0.0241668837310118 no 146 0.0524847262843144 370 2962154
SGTC_1437 4092-1038 11.6 µM 1.61149646551218 0.0247954083632268 no 147 0.053535778484331 369 3977136
SGTC_2338 7999974 200 µM 1.60792757231764 0.0250293997297355 no 148 0.053925521160432 382 315925
SGTC_2831 7999036 19.48 µM 1.60399851111892 0.0252891431479164 no 149 0.0543571903942175 404 2988270
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.59865687074285 0.0256458886318634 no 150 0.0549484328683223 390 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2184 6075246 200 µM 1.59754261856886 0.0257208334516146 no 151 0.0550724027830681 363 2267320
SGTC_1956 st077085 54 µM 1.59703377838256 0.0257551190651406 no 152 0.0551290889765828 413 24208685
SGTC_2643 anethole 100 µM 1.59353391874994 0.0259919771250298 no 153 0.0555202327182788 391 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2555 cholic acid 100 µM 1.58511941203825 0.0265689062798504 no 154 0.0564696029290451 358 6708657 Influences liver metabolism.
SGTC_209 4077-0173 175.592 µM 1.58270853441544 0.026736163127152 no 155 0.056743956097925 262 15993494
SGTC_2651 TUB2.036 5 µM 1.58184468490609 0.0267963070662174 no 156 0.0568425156005588 598 15992207 YFL037W TUB2
SGTC_1610 st001799 48.1 µM 1.58168948950008 0.0268071242244786 no 157 0.0568602366455544 306 621897
SGTC_638 3970-0837 4.09 µM 1.57716583912168 0.027124029431807 no 158 0.0573786855202469 394 4118451 YLR208W SEC13
SGTC_2144 5628481 200 µM 1.57347227934287 0.0273850951522165 no 159 0.0578047510761451 345 2818399
SGTC_1273 0849-0096 14.1 µM 1.56740582596968 0.0278184257620354 no 160 0.0585099315290706 396 5286025
SGTC_2654 protoveratrine a 100 µM 1.5611504560511 0.0282712180566616 no 161 0.0592441277585623 364 5702278 A heart drug and vasodilator.
SGTC_253 dyclonine 31.25 µM 1.55822832543918 0.0284848279814902 no 162 0.0595895663086648 435 3180 An oral anasthetic.
SGTC_1304 1165-0502 251 µM 1.55653458674175 0.0286092550738806 no 163 0.0597905124158786 453 767425
SGTC_422 cantharidin 155 µM 1.55528676539863 0.0287012126718442 no 164 0.0599388939555349 440 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1248 0469-0687 58.6 µM 1.55456643356307 0.0287544089882125 no 165 0.0600246816110581 398 4017482
SGTC_2888 9058547 12.99 µM 1.55200831497287 0.0289439883126083 no 166 0.0603301170295118 301 16476514
SGTC_879 0831-1030 162 µM 1.54945698184894 0.0291340983155744 no 167 0.0606359524970667 471 1549252
SGTC_2374 9071832 200 µM 1.54771067278213 0.0292648198913006 no 168 0.0608459856615334 356 17381698
SGTC_1472 k841-0093 193 µM 1.5404306752365 0.0298150301003811 no 169 0.0617277044791106 436 X1472
SGTC_2885 9057732 51.95 µM 1.54008116782243 0.0298416597372326 no 170 0.0617702847957886 392 6471414
SGTC_2971 9092186 9.93 µM 1.53713266158669 0.0300670982752273 no 171 0.062130413076548 377 25236400
SGTC_1018 4259-0013 28.1 µM 1.53423546343545 0.0302899874922738 no 172 0.0624858680435549 386 6801262
SGTC_1116 jasmonic acid 1.58368 µM 1.53359880371318 0.0303391505059898 no 173 0.0625641914059026 416 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_501 nsc-95397 161 µM 1.53165396085468 0.0304897413949018 no 174 0.0628039245309812 360 262093
SGTC_249 wiskostatin 11.211 µM 1.52584282253466 0.0309433961285879 no 175 0.0635245065754252 386 2775510 A n-wasp and actin depolymerizer.
SGTC_2044 5102272 200 µM 1.524147019659 0.0310768294701838 no 176 0.0637359946160907 350 592666
SGTC_3315 9136395 68.55 µM 1.5225535767167 0.0312026421527096 no 177 0.0639352158365142 419 16876844
SGTC_2838 9002687 71.43 µM 1.52249605458207 0.0312071917666963 no 178 0.0639424166239315 381 6457060
SGTC_246 cycloheximide 667 µM 1.52191147390058 0.0312534592978102 no 179 0.0640156319039093 345 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1028 k015-0029 4.8 µM 1.51847046935335 0.0315269540224043 no 180 0.064447919261081 461 4588309
SGTC_399 oxolinic acid 75 µM 1.51532981733086 0.0317783003444053 no 181 0.064844450445364 386 4628 A DNA gyrase inhibitor.
SGTC_573 3702-0553 84.7 µM 1.51421577101044 0.0318678542688188 no 182 0.0649855615032107 399 1222756
SGTC_33 0986-0033 35.816 µM 1.51309144825297 0.0319584455260721 no 183 0.065128215778805 362 2848082
SGTC_1579 chlormadinone acetate 49.4 µM 1.50793839141701 0.0323763734629836 no 184 0.0657851478372054 425 45114258 A steroidal progestin.
SGTC_3051 9093778 49.47 µM 1.50586491036732 0.0325458063707395 no 185 0.0660509280081451 314 17217378
SGTC_2298 7976326 193.81 µM 1.50490433060985 0.0326245469383849 no 186 0.0661743373859646 345 2235818
SGTC_1324 1418-0026 34.4 µM 1.49332616336217 0.03358604983156 no 187 0.0676759150972281 446 1372513
SGTC_617 3770-0098 35 µM 1.48702631260232 0.0341189402226784 no 188 0.0685039307829926 407 5962639
SGTC_109 0132-0036 33.701 µM 1.48633899532513 0.0341774971438331 no 189 0.0685947385525165 292 67274 A color developer.
SGTC_500 h-89 112 µM 1.48553330411592 0.0342462442531419 no 190 0.0687013039580303 463 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2013 4024628 200 µM 1.47670629187299 0.0350068956691558 no 191 0.069877192428796 425 5230760
SGTC_3050 9093513 49.47 µM 1.46505271011793 0.0360323025502993 no 192 0.0714532686858617 426 25236664
SGTC_3155 9099265 49.47 µM 1.46149058779068 0.0363506008574874 no 193 0.0719404283473542 392 25236499
SGTC_2655 perillic acid 100 µM 1.45989027079572 0.0364943467025349 no 194 0.0721601167812692 385 5702197 An apoptosis inducer.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.45355558675235 0.0370679205872726 no 195 0.0730347789456865 435 75037 A free radical scavenger.
SGTC_104 0074-0074 590.992 µM 1.45050347156088 0.0373468930275351 no 196 0.0734590859053947 298 3943124
SGTC_3140 9094243 49.47 µM 1.44520285664369 0.0378354593382376 no 197 0.0742004571262857 457 19291112
SGTC_2511 berberine 10.47 µM 1.44477421967518 0.037875194401388 no 198 0.0742606573381019 426 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3033 9090887 49.47 µM 1.44403831282302 0.0379434930948434 no 199 0.074364099259725 491 19325384
SGTC_1581 himbacine 57.9 µM 1.43961854247099 0.038355803966528 no 200 0.0749876753248695 487 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2192 5915882 198.485 µM 1.43715969827554 0.0385867609538923 no 201 0.0753363107623691 391 2876149
SGTC_2966 9084041 48.03 µM 1.43297586346174 0.0389823485062093 no 202 0.0759323675812167 453 17741380
SGTC_2286 7945697 125 µM 1.43071530068897 0.0391974582628713 no 203 0.0762559131224735 473 1245733
SGTC_2062 5245942 200 µM 1.42757179892877 0.0394981911891828 no 204 0.0767075727775908 479 1376160
SGTC_1363 1636-0063 10.4 µM 1.42169745108847 0.040065208651353 no 205 0.0775570502029421 493 6072185
SGTC_2949 9072542 2.23 µM 1.41597862202658 0.040623550817573 no 206 0.0783908818453133 513 16457352
SGTC_672 1441-0018 53.7 µM 1.41513818251931 0.0407061345462065 no 207 0.0785139925118936 446 251141
SGTC_1494 4358-1428 177 µM 1.41417626836866 0.0408008218303765 no 208 0.078655077036892 490 1564571
SGTC_1484 3473-2379 286 µM 1.41315749663986 0.0409013007486176 no 209 0.0788047103131734 564 671917
SGTC_3356 9151811 4.48 µM 1.41133188476214 0.041081858388908 no 210 0.0790733885604654 469 1859254 YPR165W RHO1
SGTC_1490 4089-0339 670 nM 1.40899893071379 0.0413135336425042 no 211 0.0794177421575126 418 742542
SGTC_2321 7390090 138.78 µM 1.40616904326533 0.0415959773160503 no 212 0.0798369671174208 422 649046
SGTC_2278 7948257 134.34 µM 1.40545742841532 0.0416672473341008 no 213 0.0799426499945137 459 1247028
SGTC_1839 st053978 48 µM 1.40007241514011 0.0422097817634862 no 214 0.0807458172479744 469 3788398
SGTC_1711 st032263 62.8 µM 1.39823303727036 0.0423964016096972 no 215 0.0810215494481138 452 3958979
SGTC_2791 5663188 71.43 µM 1.39371474202747 0.0428576535492958 no 216 0.0817018813475903 457 54690634
SGTC_527 4476-4215 268 µM 1.39361482663976 0.0428678991021125 no 217 0.0817169743980977 499 4418754
SGTC_2204 7233102 200 µM 1.39350630114096 0.0428790297979776 no 218 0.0817333704587516 404 2172480
SGTC_887 0885-0007 9.62 µM 1.39196072368826 0.0430378024191102 no 219 0.0819671459270034 519 5719458
SGTC_2963 9082507 9 µM 1.38848717722482 0.0433963630086922 no 220 0.0824943733541872 458 16459611
SGTC_1187 1391-0724 117 µM 1.38795751754408 0.0434512490130783 no 221 0.0825749908361044 517 6997986
SGTC_130 0136-0219 337.655 µM 1.3843623061302 0.0438252856154147 no 222 0.0831237723485666 490 234244
SGTC_593 1203-0218 61.7 µM 1.38411908429874 0.0438506833055889 no 223 0.0831609971122968 500 3666956
SGTC_2199 6590217 200 µM 1.38252404948377 0.0440175342641816 no 224 0.0834054256843694 410 703109
SGTC_2812 7970281 58.44 µM 1.37949355244728 0.0443359540269182 no 225 0.0838713163964862 500 2233435
SGTC_2698 st077697 67.5 µM 1.37815198469658 0.0444775064946883 no 226 0.0840781841243293 467 3154499
SGTC_791 1348-1292 225 µM 1.37670949451005 0.0446301135662006 no 227 0.0843010410593635 587 5437054
SGTC_2292 7671323 168.05 µM 1.37340617788224 0.0449811741640602 no 228 0.0848130551404729 504 937504
SGTC_525 k781-2675 26.7 µM 1.36751410655046 0.04561287079854 no 229 0.0857321093612984 537 3651118 YDL195W SEC31
SGTC_2194 5927483 104.545 µM 1.36604846587156 0.0457711067028497 no 230 0.0859618759016947 532 760979
SGTC_2358 9037157 4 µM 1.36446650490798 0.0459423957604146 no 231 0.0862103945854472 505 2388925
SGTC_2774 tamoxifen 10.92 µM 1.36255847606865 0.0461496750719988 no 232 0.0865108515131014 485 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1479 0549-0158 134 µM 1.36110780274349 0.0463077715003912 no 233 0.0867398121006 556 5440202
SGTC_3314 9135860 59.4275 µM 1.36019789434311 0.0464071563220441 no 234 0.0868836543695266 510 25252478
SGTC_1802 st050112 57.9 µM 1.35498812807554 0.0469794946719727 no 235 0.0877106697556866 514 4662563
SGTC_3069 9117009 49.47 µM 1.3529859351954 0.0472009531340835 no 236 0.0880300618436851 386 41904981
SGTC_450 aminopyrene 156 nM 1.35170721468135 0.0473428271323077 no 237 0.0882344980858219 510 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2070 5230947 200 µM 1.34660195193519 0.0479126648080905 no 238 0.0890542325883114 533 2835538
SGTC_69 0096-0274 206.684 µM 1.34578919895704 0.048003886967333 no 239 0.0891852548766785 596 6741392
SGTC_307 1501-1223 22.3 µM 1.34471807681001 0.048124320349061 no 240 0.0893581473645357 514 2830329
SGTC_797 k781-0471 270 µM 1.33952048601522 0.0487121570391614 no 241 0.0902006449316153 520 23738129
SGTC_442 cape 100 µM 1.33897610405073 0.0487740561334489 no 242 0.0902892261293401 470 5281787
SGTC_2787 5284540 71.43 µM 1.33735382572228 0.0489588905861204 no 243 0.0905535844961463 511 736958
SGTC_2558 carylophyllene oxide 100 µM 1.33454098144819 0.0492806982980071 no 244 0.0910133126939555 555 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1670 st016595 4.04 µM 1.32719024540147 0.0501296481467487 no 245 0.0922228791724668 530 597879
SGTC_2242 6630449 61.2675 µM 1.32664486988895 0.0501930963275533 no 246 0.0923130928404218 452 691249 YDR170C SEC7
SGTC_1614 st002383 48.6 µM 1.32506925695902 0.0503767604780317 no 247 0.0925740908304606 530 1947235
SGTC_2396 5342950 42.78 µM 1.31910612506151 0.0510767171014086 no 248 0.0935668178800814 584 1886677
SGTC_1260 0700-1617 7.75 µM 1.31815840857414 0.0511886701558578 no 249 0.0937253126127625 576 2853078
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.31532189956735 0.0515249119172066 no 250 0.0942008705636814 510 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2630 antimycin a 100 µM 1.31511643849272 0.0515493354728849 no 251 0.0942353863686757 575 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_994 3910-0338 138 µM 1.31337445474258 0.0517567785243465 no 252 0.0945284005009461 572 3479481
SGTC_1830 st055982 50.3 µM 1.30976331142473 0.0521889225074724 no 253 0.0951379591080385 549 455313 An antimicrobial agent.
SGTC_3073 9114972 49.47 µM 1.30875887201267 0.0523096313764853 no 254 0.0953080212752361 474 41905075
SGTC_3283 9109332 35.8195 µM 1.30687424676734 0.0525367150187427 no 255 0.095627711911561 450 17027281
SGTC_3270 9137563 49.47 µM 1.30009209634263 0.0533603954240956 no 256 0.0967847031098024 482 17015724
SGTC_2235 salicylic acid 500 µM 1.29885984889091 0.0535111426082663 no 257 0.096996015505369 523 338 A COX inhibitor and kinase inhibitor.
SGTC_72 0744-0168 198.391 µM 1.29628538108636 0.0538271793342914 no 258 0.0974385916039757 536 677577
SGTC_2512 diallyl trisulfide 49.23 µM 1.29548607378016 0.0539256008778576 no 259 0.0975763011958301 504 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2736 butenafine 14.65 µM 1.29484681051862 0.0540044181275238 no 260 0.0976865400905758 595 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_657 3534-0529 86.7 µM 1.29037829500203 0.0545579081827843 no 261 0.0984596722105174 539 1049549
SGTC_2366 9070441 60.58 µM 1.28751199691209 0.0549152957360044 no 262 0.0989579454053379 571 6837235
SGTC_1254 0550-0035 264 µM 1.28716732150786 0.0549583963047726 no 263 0.0990179873195067 589 15121435
SGTC_277 nystatin 15.5 µM 1.28620995304934 0.0550782524534715 no 264 0.099184899197867 580 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2167 5876490 200 µM 1.28329435928194 0.0554445378101055 no 265 0.0996944840698097 555 686534
SGTC_3004 9076122 71.4286 µM 1.28098996183799 0.0557353972608369 no 266 0.100098595985233 563 44782551
SGTC_419 nsc-638432 893 µM 1.27877637988075 0.0560159265879342 no 267 0.100487906945936 569 368090
SGTC_3193 9111931 49.47 µM 1.27737235449741 0.0561944364682462 no 268 0.100735410053691 565 17087244
SGTC_929 2805-0021 398 µM 1.27148240377779 0.0569481857588868 no 269 0.101778541742302 544 3098024
SGTC_1153 4055-0057 267 µM 1.27104479689464 0.0570045034143889 no 270 0.101856356171656 585 882706
SGTC_2342 7990637 118.86 µM 1.26545182824978 0.057728156279908 no 271 0.102854703117814 595 2033102 YER133W GLC7
SGTC_610 4215-0184 155 µM 1.26383749298872 0.0579383668096727 no 272 0.103144180457773 603 5605015
SGTC_332 4112-0506 40.9 µM 1.26256742406112 0.0581041712226844 no 273 0.103372340593681 576 2790355
SGTC_3032 9089427 49.47 µM 1.25962613543064 0.0584895807863457 no 274 0.103902131392624 527 17173707
SGTC_2323 6148992 148.28 µM 1.25647420655684 0.0589048166174703 no 275 0.104472045965205 511 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2460 5552655 174.22 µM 1.25209432821221 0.0594856588417594 no 276 0.105267747087683 568 5401989
SGTC_1596 piperlongumine 63 µM 1.2512256811377 0.0596013870951872 no 277 0.105426075591935 652 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2508 celastrol 40.54 µM 1.24943716525832 0.0598402233599281 no 278 0.105752611083271 523 122724 Celastrol is a natural product and antioxidant.
SGTC_2760 etidronate 98.04 µM 1.249405294639 0.0598444861129686 no 279 0.105758436434667 560 3305 A chelator and antioxidant.
SGTC_2667 digitoxin 100 µM 1.24836733345547 0.0599834453652134 no 280 0.105948283085764 488 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2110 5483698 200 µM 1.24690354416838 0.0601798425574925 no 281 0.106216433528627 576 2848765 YHR062C RPP1
SGTC_2903 5923464 63.88 µM 1.24241827429161 0.0607847685345474 no 282 0.107041138311646 565 2876576
SGTC_184 1494-0393 24.714 µM 1.23924629851632 0.0612154342309596 no 283 0.107627149719799 612 3090647
SGTC_1181 1222-0449 220 µM 1.23759231394797 0.0614409429727272 no 284 0.107933632902259 595 658318
SGTC_1681 tripelennamine 100 µM 1.23517181803818 0.0617721289625496 no 285 0.108383282680352 514 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2426 5582046 32.21 µM 1.2346930307942 0.0618378041438108 no 286 0.108472385301943 613 2251934
SGTC_3203 9113543 49.47 µM 1.23419245510117 0.0619065263092197 no 287 0.108565599108672 571 17018012
SGTC_1097 itavastatin 7.23 µM 1.23346816410695 0.0620060670106467 no 288 0.108700573639367 606 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_35 0133-0054 64.071 µM 1.23108972650228 0.0623338188772316 no 289 0.109144653748423 558 99677
SGTC_56 0957-0365 83.25 µM 1.21971121414664 0.0639205194866692 no 290 0.111287184473366 616 6752360
SGTC_950 1165-0508 94.1 µM 1.21956630675372 0.0639409270827317 no 291 0.111314662783832 571 6148369
SGTC_380 3970-0968 6 µM 1.21304572394317 0.0648644878250465 no 292 0.112556169722224 584 2891601
SGTC_1201 1889-3372 45.9 µM 1.21303682315624 0.0648657555533887 no 293 0.112557871148003 577 5392199
SGTC_832 4083-0019 164 µM 1.2047614216891 0.0660527559110838 no 294 0.114147708433958 819 1990758
SGTC_1663 st014140 55.4 µM 1.20396195387132 0.0661683150031245 no 295 0.114302142032312 708 4207120
SGTC_1914 st062367 72.6 µM 1.19845703949629 0.0669682791877727 no 296 0.115369569069547 591 978205
SGTC_2234 tolnaftate 200 µM 1.19475888071482 0.0675098759923806 no 297 0.116090625034775 556 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1045 1348-1485 165 µM 1.19270935982555 0.0678114834420522 no 298 0.116491609344429 673 6810614
SGTC_26 0302-0163 425.158 µM 1.19268253103312 0.0678154384561035 no 299 0.116496864845299 624 3100915
SGTC_2776 terbinafine 19.92 µM 1.19229226706311 0.0678729900588672 no 300 0.116573332797485 592 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1298 1079-1278 263 µM 1.19204743977054 0.0679091135964791 no 301 0.11662132219118 661 2840950
SGTC_3065 9113888 49.47 µM 1.1907831661999 0.0680958897263636 no 302 0.116869359523008 579 16648368
SGTC_1074 carmofur 3.8 µM 1.19071494953882 0.0681059789081222 no 303 0.11688275354704 691 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2467 5474540 200 µM 1.18414828544053 0.0690825950660878 no 304 0.11817718457283 626 5413519
SGTC_2481 5478948 45.16 µM 1.1770242020124 0.0701542798766798 no 305 0.119592923261435 615 77792
SGTC_389 tpck 16.7 µM 1.17702311640599 0.0701544441547692 no 306 0.119593139907099 628 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2387 9077560 195.08 µM 1.17630355573868 0.0702633959202679 no 307 0.119736797697151 645 5303272
SGTC_495 decylubiquinone 155 µM 1.17538068305906 0.0704033224431974 no 308 0.119921224088053 617 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_740 k014-0057 261 µM 1.17368591230257 0.0706608424835458 no 309 0.12026042752701 712 4012779
SGTC_3108 9121785 49.47 µM 1.17006952212548 0.0712127719127083 no 310 0.120986496196779 625 17140271
SGTC_2238 6671620 73.2395 µM 1.16981052508342 0.0712524264092082 no 311 0.121038613566201 608 729941
SGTC_1545 lovastatin 49.4 µM 1.16946262223765 0.0713057197646716 no 312 0.121108646097953 678 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_313 3474-0040 5.03 µM 1.16386209314442 0.0721678513332654 no 313 0.122239951834288 691 1043375 YIL048W NEO1
SGTC_770 0389-1121 67.2 µM 1.1622213984494 0.0724219229518824 no 314 0.122572772392586 697 6753108
SGTC_2561 acetosyringone 100 µM 1.15864104443389 0.0729787415203287 no 315 0.123301265601509 735 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3246 9135460 32.98 µM 1.15665721662019 0.0732886751069704 no 316 0.123706217894263 569 41446951
SGTC_1202 1988-0068 29.6 µM 1.15251145637245 0.0739396171522064 no 317 0.124555482388699 687 2850480
SGTC_651 3253-0966 34.4 µM 1.15121312135356 0.0741443795950314 no 318 0.124822284196898 684 781462
SGTC_2172 5754775 163.918 µM 1.14889368606344 0.0745112590325662 no 319 0.125299910745961 612 2263357
SGTC_321 4534-3890 65.3 µM 1.14641234405956 0.0749052807907982 no 320 0.125812288754242 670 699746
SGTC_694 1315-0438 43.2 µM 1.14203612580517 0.0756040679428197 no 321 0.126719501862348 569 6793154
SGTC_3206 9114350 49.47 µM 1.13899530453323 0.0760925382231035 no 322 0.127352556318778 629 17087243
SGTC_512 prima-1 270 µM 1.13828244212519 0.0762073976093085 no 323 0.127501281570682 698 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1791 st048313 56.1 µM 1.13094023381323 0.0773980949290865 no 324 0.129040123785944 621 1204976
SGTC_1565 sinapyl alcohol 95.1 µM 1.13059822892124 0.0774539008833353 no 325 0.129112116648423 636 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1475 4092-1048 11.7 µM 1.12660746905961 0.0781073455424469 no 326 0.129954239902748 731 2881759
SGTC_3302 9125395 16.351 µM 1.12488296373903 0.0783910056301085 no 327 0.130319316019707 672 17599668
SGTC_2332 7982454 138.89 µM 1.12409131336854 0.078521483746217 no 328 0.13048714502816 699 2981748
SGTC_900 1112-0045 141 µM 1.12372402902055 0.0785820746429172 no 329 0.13056505964567 548 56211 YIL048W NEO1
SGTC_2515 chrysin 20.77 µM 1.11456260197117 0.0801049263597845 no 330 0.132518951932026 700 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2180 6301957 200 µM 1.10946533407347 0.0809618199867491 no 331 0.13361474556556 707 845462
SGTC_1762 st045503 25.4615 µM 1.10865950696346 0.0810979173307971 no 332 0.133788548302874 699 4645554
SGTC_2446 5162541 200 µM 1.10614699281192 0.0815233679879816 no 333 0.134331450795493 664 1549321
SGTC_1290 0986-0249 10.2 µM 1.10535695937218 0.081657493663275 no 334 0.134502472936829 638 53329
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.10451057585731 0.0818013705293962 no 335 0.134685859215778 693 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.10342779588125 0.0819857109410611 no 336 0.134920715685554 746 6708561
SGTC_1228 0124-0032 52.5 µM 1.09898116073168 0.0827460218583216 no 337 0.135888141682894 711 X1228
SGTC_386 1509-0011 3.07 µM 1.09873323799612 0.0827885687329282 no 338 0.135942220093546 794 3107280
SGTC_1821 st053465 65.6 µM 1.09867144523788 0.082799175763266 no 339 0.135955700998362 675 675086
SGTC_710 3448-4187 58 µM 1.09054918447532 0.0842023198880879 no 340 0.13773564993264 806 3946412
SGTC_2606 farnesol 9.78 µM 1.08908823135496 0.0844565866141179 no 341 0.138057489569494 732 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2477 5967686 25.23 µM 1.08257845526748 0.0855965643577573 no 342 0.13949778725556 716 776118
SGTC_2954 9074818 52.69 µM 1.08150013392172 0.0857865047640518 no 343 0.139737350573871 704 16648742
SGTC_1037 k284-1091 78.7 µM 1.080004831218 0.0860504159954507 no 344 0.140070014403985 674 3334711
SGTC_2906 7926292 26.41 µM 1.07903972377412 0.0862210734654838 no 345 0.140285009826088 717 2966319
SGTC_1750 st081859 2.357 µM 1.07850850844314 0.0863151148603805 no 346 0.14040344338638 880 5291695
SGTC_1698 5-fluorocytosine 1.055 µM 1.07524717416023 0.0868941526988787 no 347 0.141132040027759 731 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_800 3448-7362 155 µM 1.0690676402661 0.0879992568495673 no 348 0.142519595850925 958 15991913
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.06444643485595 0.0888325050042374 no 349 0.143563253886132 709 140250 A respiratory chain inhibitor.
SGTC_1849 st056239 19.2 µM 1.06230854493764 0.0892199689193774 no 350 0.144047818241433 734 5393181
SGTC_750 4073-0104 132 µM 1.05785715964668 0.090030755481224 no 351 0.145060284395337 626 22330957
SGTC_3059 1327-0034 3 µM 1.0537287667294 0.0907875928842102 no 352 0.146003557302372 733 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2696 st077691 74.316 µM 1.05325812401254 0.0908741723348477 no 353 0.146111352864644 669 757133
SGTC_2473 5854593 8.94 µM 1.05134375419168 0.0912269712802142 no 354 0.146550369199735 725 2872951
SGTC_3180 9109287 49.47 µM 1.0510995990145 0.091272039526747 no 355 0.146606424121482 699 18891271
SGTC_975 1335-0046 28.5 µM 1.05094994265367 0.0912996725343528 no 356 0.146640790429642 741 16486740
SGTC_1105 epirubicin 18.1 µM 1.05012305364413 0.0914524636664553 no 357 0.146830770368241 733 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2902 5787006 60.46 µM 1.04678251534478 0.0920716522157824 no 358 0.147599948153317 740 591003
SGTC_789 1309-1135 70.6 µM 1.04452047599278 0.0924926936542041 no 359 0.148122325396536 745 3092424
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.03980289737819 0.093375373767777 no 360 0.149215741372476 805 6708784 An antioxidant flavonoid
SGTC_640 3381-0960 37.1 µM 1.03974111477094 0.0933869747084268 no 361 0.149230096690151 803 1745025
SGTC_396 dithiazanine 1.25 µM 1.039272431553 0.0934750141872863 no 362 0.14933902624642 718 10578 An antihelmenthic.
SGTC_1847 st056231 15 µM 1.03565326718952 0.094156918879176 no 363 0.150181965896434 818 5393180
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.03286784827009 0.0946842273210816 no 364 0.15083287343329 816 676296 Flavone; oxidizing agent.
SGTC_882 0843-0131 351 µM 1.032218833578 0.0948074045349693 no 365 0.150984807088549 814 5425421
SGTC_2945 9067681 61.76 µM 1.0286237158467 0.0954918651290777 no 366 0.151828264589556 751 16456930
SGTC_378 3970-0959 8.33 µM 1.02757892602315 0.0956914590342526 no 367 0.152073970743237 775 6615653
SGTC_2405 ticlatone 3.52 µM 1.02197467361761 0.0967673216141738 no 368 0.153396443725733 747 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1514 1189-1591 158 µM 1.02153729218327 0.0968516590292471 no 369 0.153499975077731 806 767698 YMR146C TIF34
SGTC_1982 st072467 71.9 µM 1.01930489110639 0.0972829592401879 no 370 0.154029121336118 826 3163533
SGTC_303 1348-1668 34.2 µM 1.01669689809342 0.0977886066844813 no 371 0.154648820914961 771 5380509
SGTC_2066 5222451 176 µM 1.01397822223003 0.0983177619586157 no 372 0.155296572017538 837 2281147
SGTC_511 blebbistatin 171 µM 1.01386952798879 0.0983389614065618 no 373 0.155322506656031 776 3476986 A myosin inhibitor.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.01370405227332 0.0983712417959531 no 374 0.15536199494273 769 5355888
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.01033619160438 0.0990299186021391 no 375 0.15616712362633 823 165521
SGTC_1335 1486-0900 202 µM 1.0057119369652 0.0999395651006243 no 376 0.157277079679656 810 X1335
SGTC_350 k064-0020 19.8 µM 1.00311151941495 0.100453771493006 no 377 0.157903528648582 854 2790705
SGTC_2315 7733312 200 µM 1.00305353686912 0.100465258918536 no 378 0.15791751547923 735 726316
SGTC_1742 st038235 28.8875 µM 1.00266107145896 0.100543038849499 no 379 0.158012209275328 774 564103 YBR002C RER2
SGTC_559 1550-0661 158 µM 1.00133659834176 0.100805851044837 no 380 0.158332052402006 806 5830875
SGTC_2362 9071156 126 µM 1.00123558757575 0.100825914921821 no 381 0.158356462616028 801 653133
SGTC_2674 ligustilide 100 µM 0.99733889933139 0.101602142632889 no 382 0.15930001913986 765 5319022 A signalling regulator.
SGTC_1607 st000305 50.6 µM 0.997239672626313 0.10162196544005 no 383 0.159324094181548 812 5457690
SGTC_2576 guaiol 23.12 µM 0.996974890772889 0.101674875463727 no 384 0.159388348972833 856 227829
SGTC_269 exalamide 29 µM 0.996432071069207 0.101783407092718 no 385 0.159520128434403 793 3316 A derivative of salicylamide.
SGTC_196 k015-0023 18.111 µM 0.996353210581832 0.101799181509375 no 386 0.159539279198743 824 5211998
SGTC_2977 9011197 71.43 µM 0.995820781048596 0.101905729643753 no 387 0.159668615677631 728 2704722
SGTC_3107 9121808 49.47 µM 0.992559235872898 0.102560191679042 no 388 0.160462399307415 772 662681
SGTC_673 1082-0474 110 µM 0.991124975171 0.102848955862367 no 389 0.160812279535128 888 3098046
SGTC_1302 1159-0335 255 µM 0.987815844891184 0.103517446236917 no 390 0.161621423042221 792 649284
SGTC_54 0159-0055 9 µM 0.987550788707834 0.103571127366273 no 391 0.161686348779656 817 3319099
SGTC_898 1000-0849 28.3 µM 0.980485277964103 0.105009540892092 no 392 0.163423316600714 844 6751807
SGTC_665 3914-0008 307 µM 0.978689366286645 0.105377450904152 no 393 0.163866743903306 795 1069549
SGTC_1684 st024538 14.6195 µM 0.978000250888926 0.105518870164946 no 394 0.164037099998945 832 6732859
SGTC_3208 9114115 49.47 µM 0.976347361270274 0.105858633087795 no 395 0.164446178657694 715 650895
SGTC_1038 k292-0204 154 µM 0.97606281082984 0.1059172040944 no 396 0.164516669571159 758 4454212
SGTC_1987 st072290 61.9 µM 0.975948592871047 0.105940720961446 no 397 0.164544969985456 845 54697379
SGTC_1001 4048-4355 44.4 µM 0.972540712971633 0.106644121935769 no 398 0.165390810451039 816 21824233
SGTC_3030 9087619 49.47 µM 0.97146277923616 0.106867312246868 no 399 0.165658939675899 841 25236973
SGTC_760 0568-0725 82.9 µM 0.971357142163096 0.106889202926034 no 400 0.165685231346747 894 3916171
SGTC_2979 9012552 45.46 µM 0.969251960957142 0.107326124648428 no 401 0.166209745714449 789 17100905
SGTC_1413 3910-0535 34.4 µM 0.968370227957446 0.107509506766928 no 402 0.166429751377064 886 2876951
SGTC_3103 9120822 49.47 µM 0.968270361990983 0.107530291037769 no 403 0.166454681287914 873 17141819
SGTC_741 4582-0002 126 µM 0.968073841315195 0.107571199702626 no 404 0.166503746511351 816 2912688
SGTC_1573 oleylamine 1.06 µM 0.962872605105111 0.108657992560597 no 405 0.167805729460716 812 5356789 An amine of the fatty acid oleic acid.
SGTC_18 0111-0177 500 nM 0.961956920239334 0.108850138599872 no 406 0.168035622153974 932 721752
SGTC_819 1013-0258 27.7 µM 0.961445335514303 0.10895759513677 no 407 0.168164149301691 827 5753198
SGTC_1420 4'-methoxyflavone 42 µM 0.960920326240593 0.109067950712623 no 408 0.168296114887547 856 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2486 5283202 22.39 µM 0.958786541422959 0.109517293372095 no 409 0.168833145304998 785 1377751
SGTC_3130 9127414 49.47 µM 0.957746651816046 0.109736759493028 no 410 0.169095263064707 843 1494646
SGTC_375 3970-0961 9.27 µM 0.954921804671641 0.110334529669265 no 411 0.169808621061917 853 2898222
SGTC_1980 st071811 45.7 µM 0.95456225818959 0.110410781037509 no 412 0.169899555497452 843 4974850
SGTC_2176 5809774 33.9695 µM 0.952663331956304 0.110814125468942 no 413 0.170380338791636 891 2870539
SGTC_796 1234-0020 70.7 µM 0.952657877040113 0.11081528564773 no 414 0.170381721159135 811 46495034
SGTC_1408 3909-7976 48.8 µM 0.952206189359119 0.110911383034528 no 415 0.170496211338185 889 24152374
SGTC_830 4076-0286 57.8 µM 0.951141612395115 0.111138109865968 no 416 0.170766246623786 969 6866659
SGTC_1055 3448-0672 86 µM 0.94943668798733 0.11150190485507 no 417 0.171199279119789 819 748378
SGTC_2594 a-mangostin 100 µM 0.946987213619361 0.112026061565948 no 418 0.171822647239461 853 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_967 1306-0166 352 µM 0.946050193600787 0.11222703717856 no 419 0.172061492830703 861 4437607
SGTC_489 paxilline 115 µM 0.945713887120713 0.112299232271592 no 420 0.172147268718282 803 105008 A toxic potassium channel blocker.
SGTC_1721 st082152 9.2685 µM 0.944990042208341 0.112454733022354 no 421 0.172331979905666 811 5296051
SGTC_2531 methyl deoxycholate 70.07 µM 0.943951749154586 0.112678053911987 no 422 0.172597152834505 808 16667744 Haematoxylin.
SGTC_40 0327-0103 19.753 µM 0.942051683292537 0.113087548612154 no 423 0.173083089919378 823 409036
SGTC_417 st075190 100 µM 0.940836488935025 0.11334999865482 no 424 0.173394329286137 899 222757
SGTC_3164 9100705 49.47 µM 0.940214065112662 0.113484593963697 no 425 0.173553884305816 845 17174235
SGTC_42 0133-0086 60.653 µM 0.939318963051138 0.113678353996921 no 426 0.173783502673391 798 162923 Model of phenazepam hydroxylation.
SGTC_3279 9140807 49.47 µM 0.938455286450336 0.113865534896803 no 427 0.174005242632672 872 45595718
SGTC_3324 9138759 60.749 µM 0.931888088723645 0.115296002000856 no 428 0.175697181981358 867 45595710
SGTC_1669 st015249 58.4 µM 0.930722389477671 0.11555124372712 no 429 0.175998592484121 959 722793
SGTC_2119 5528445 120.635 µM 0.9305752121164 0.115583498230804 no 430 0.176036670849012 892 791935
SGTC_2058 5236698 133 µM 0.929547940039061 0.115808807127733 no 431 0.176302596375091 842 766665
SGTC_150 3970-0969 77.2 µM 0.928311931463324 0.116080310834338 no 432 0.176622893353068 913 6615640
SGTC_3286 9117135 37.221 µM 0.927962234557327 0.116157207770967 no 433 0.176713579901712 830 3438150
SGTC_1758 st042942 75.2445 µM 0.926873302180153 0.116396891146854 no 434 0.17699616016444 869 669317
SGTC_285 1486-1325 46 µM 0.925253665739802 0.116754035716262 no 435 0.177416987090252 903 22310230
SGTC_1469 k284-2957 126 µM 0.91874979231633 0.118196020785078 no 436 0.179113229604647 890 23884841
SGTC_2131 toluylene red 5.2905 µM 0.916319288089242 0.118738111282067 no 437 0.179749727191878 861 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_331 k048-0133 24.5 µM 0.911273532449842 0.119869099875371 no 438 0.18107563421968 850 6813582
SGTC_761 k216-0224 480 µM 0.909331810210737 0.120306347458881 no 439 0.181587502114346 978 1340404
SGTC_146 3448-8650 53.125 µM 0.90923516916967 0.120328138928885 no 440 0.181613001815717 982 2891488 YIL048W NEO1
SGTC_747 3448-8087 38.7 µM 0.908874523629923 0.120409484998859 no 441 0.181708181517318 891 5168703
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.907275048589163 0.120770724340991 no 442 0.182130682720424 976 688801
SGTC_731 3966-0296 387 µM 0.906070375937338 0.121043301238021 no 443 0.182449301998142 904 660956
SGTC_22 0964-0034 14.468 µM 0.90268501500617 0.121811610716513 no 444 0.183346545850274 926 138402
SGTC_1751 st044839 27.194 µM 0.902267565461306 0.121906587877994 no 445 0.183457375399064 910 5291326
SGTC_3271 9137798 49.47 µM 0.901988889290612 0.121970020586883 no 446 0.183531384955514 830 6498326
SGTC_1505 k297-0037 20.6 µM 0.901343075074652 0.122117110938154 no 447 0.183702968890354 895 4089396
SGTC_202 3594-0513 34.79 µM 0.899287047850197 0.122586220068976 no 448 0.184249892257748 882 708429
SGTC_2413 inermin 26.06 µM 0.899225553427008 0.122600270260685 no 449 0.184266265967923 930 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_913 3487-1245 167 µM 0.89527903605514 0.123504330840827 no 450 0.185318971989176 870 4016153
SGTC_2886 9058944 51.95 µM 0.893443997431613 0.123926284421401 no 451 0.185809725008651 780 4949929
SGTC_1648 st011736 69.8 µM 0.891438834976434 0.12438850916129 no 452 0.186346895726061 902 2855514
SGTC_2101 5377231 179.231 µM 0.890692381634197 0.124560887163137 no 453 0.186547111492227 922 2844213
SGTC_2506 ethyl hematommate 54.16 µM 0.890003323959097 0.124720158987175 no 454 0.186732050630591 833 3940691 An allergen.
SGTC_2983 9022671 12.99 µM 0.886243189132559 0.125591800451541 no 455 0.187743247549889 899 6405161
SGTC_2037 5169046 200 µM 0.886022070773361 0.125643190173722 no 456 0.187802817071896 923 5718022
SGTC_2847 9005661 71.43 µM 0.88582713370056 0.125688507316818 no 457 0.187855343008015 832 2991449
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.885255025418278 0.12582157152445 no 458 0.188009550375726 928 229346 A bile salt which induces apoptosis.
SGTC_1981 st071826 47 µM 0.884410458053566 0.12601818535621 no 459 0.188237339765214 868 11838600
SGTC_795 0685-0265 78 µM 0.884290208061625 0.126046196759707 no 460 0.188269786394149 956 302754
SGTC_2400 5203494 178.7 µM 0.88357560021503 0.126212749263735 no 461 0.188462677671148 860 6777674
SGTC_1756 st041558 35.5 µM 0.882955030025264 0.126357508952038 no 462 0.188630284573577 1009 3955792
SGTC_2673 kobusone 100 µM 0.882474777004188 0.126469616399366 no 463 0.188760056922921 972 6710676 An epoxy ketone and protein crosslinker.
SGTC_2540 epiandrosterone 100 µM 0.880977325654162 0.126819617454506 no 464 0.18916504631453 1099 441302 A steroid.
SGTC_3124 9127567 49.47 µM 0.876195905450449 0.127941696495829 no 465 0.190461771042264 914 17592030
SGTC_538 2922-0838 53.3 µM 0.874225747208516 0.128406043844793 no 466 0.190997663540545 1007 777039
SGTC_1402 3909-7673 35.9 µM 0.872635978415524 0.128781589007426 no 467 0.191430761777388 924 5328014
SGTC_2729 fluphenazine 10.66 µM 0.872375109884318 0.128843285709768 no 468 0.191501887216938 972 3372 An atypical antipsychotic.
SGTC_3117 9124945 49.47 µM 0.86966818002833 0.129484698347355 no 469 0.192240883149769 844 17592065
SGTC_2389 9091542 195.52 µM 0.869081234803832 0.12962406759142 no 470 0.192401349902577 930 3626624 YOL127W RPL25
SGTC_1440 4100-1550 40 µM 0.866093595889811 0.13033508823069 no 471 0.19321941842944 993 742806
SGTC_2835 9006588 71.43 µM 0.865816791175836 0.130401100587138 no 472 0.193295319783269 871 2345538
SGTC_3109 9122853 49.47 µM 0.865434628015463 0.130492276812814 no 473 0.193400140891867 1023 1234709
SGTC_120 rhodamine 6G 52.259 µM 0.865020588679453 0.130591107781522 no 474 0.19351374424714 1084 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_648 0375-0473 33.3 µM 0.864883097855042 0.130623938212015 no 475 0.193551477728662 976 1713139
SGTC_105 0111-0055 734.78 µM 0.863902741121878 0.13085819585088 no 476 0.193820660451456 846 5179370
SGTC_2347 9049783 174.81 µM 0.862146762979689 0.131278514753168 no 477 0.19430338051126 992 6467988 YPL169C MEX67
SGTC_1843 st055809 45.5 µM 0.861930141485966 0.131330430786409 no 478 0.194362980648796 898 16413835
SGTC_210 3551-0445 56.827 µM 0.860318119630016 0.131717217152159 no 479 0.194806853671199 953 2865180 YOR207C RET1
SGTC_1354 1498-1681 81 µM 0.860287847339843 0.131724488156152 no 480 0.194815195092598 992 5754243
SGTC_2999 9069765 71.4286 µM 0.856808718997303 0.132561974257405 no 481 0.195775303134763 994 2097066
SGTC_1127 asiatic acid 681.4 nM 0.856651763979405 0.132599842319077 no 482 0.195818684386809 907 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1804 st050076 49.1 µM 0.855170012610206 0.132957707256947 no 483 0.196228517379859 954 3895976
SGTC_1705 st027868 56.3335 µM 0.853764714760914 0.133297721357803 no 484 0.196617684458105 995 292948
SGTC_65 0798-0905 34.986 µM 0.852730404614022 0.133548356260233 no 485 0.196904412940715 1019 3602145
SGTC_1629 st005085 44.9 µM 0.851463379602908 0.133855824239177 no 486 0.19725599875269 950 24207091
SGTC_2821 7996764 71.43 µM 0.850850016801008 0.13400484315651 no 487 0.197426336669048 1021 2987135
SGTC_1474 0330-0125 5.35 µM 0.84794525242859 0.134712115114654 no 488 0.198234230581138 1006 X1474
SGTC_911 3456-4043 236 µM 0.847100342240165 0.134918319695693 no 489 0.198469597192819 1003 914281
SGTC_1183 1254-0324 198 µM 0.846626706098891 0.135034007637008 no 490 0.198601611716225 988 5799357
SGTC_232 clozapine 119 µM 0.845269361201619 0.135365922532814 no 491 0.198980231766465 957 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2923 7992654 58.14 µM 0.844210235540178 0.13562530122853 no 492 0.199275967951154 956 2985126
SGTC_957 1187-1561 14.1 µM 0.843370604824828 0.135831167657098 no 493 0.199510603274277 980 1538454
SGTC_3009 9080819 71.4286 µM 0.842427169369483 0.136062740837756 no 494 0.199774445195823 978 17027216
SGTC_2749 bexarotene 57.39 µM 0.842001131145052 0.136167403581106 no 495 0.199893660149623 943 82146 An retinoic acid receptor inhibitor.
SGTC_607 4491-0986 66.8 µM 0.840814693560631 0.136459160262479 no 496 0.200225877120397 1008 698981 YDR232W HEM1
SGTC_3016 9080866 49.47 µM 0.837218888000018 0.137346014713187 no 497 0.201234771203609 1026 17066299
SGTC_2361 9034121 116 µM 0.832992534573519 0.138393406489996 no 498 0.202424469823222 968 6496917
SGTC_1575 cyproterone acetate 48 µM 0.830572044757432 0.138995707396499 no 499 0.203107716325044 973 9880 An androgen receptor antagonist and liver toxin.
SGTC_487 nimodipine 119 µM 0.829929258806835 0.139155954021473 no 500 0.203289390560122 920 4497 L-type voltage-gated calcium channels inhibitor
SGTC_123 0083-0120 66.675 µM 0.829565364335511 0.139246728681105 no 501 0.203392283093287 982 16001701
SGTC_2773 thioridazine 9.09 µM 0.829467725299331 0.139271091910985 no 502 0.20341989618484 1060 5452 An antipsychotic.
SGTC_3327 9140648 26.9345 µM 0.826886271514425 0.139916277368918 no 503 0.204150762680776 1001 8029710
SGTC_571 k831-0106 44.2 µM 0.826799549441933 0.139937987116766 no 504 0.204175342734835 958 4783639
SGTC_3305 9127027 53.8275 µM 0.823613310931357 0.140737208036703 no 505 0.20507965511626 993 41905295
SGTC_1704 st028805 70.8 µM 0.823410258692627 0.14078824547079 no 506 0.205137365603753 982 2876101
SGTC_2658 polymyxin b sulfate 77.05 µM 0.82288769716449 0.140919649705092 no 507 0.205285929787299 1004 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1612 st002233 45.4 µM 0.819633784664546 0.141739755884345 no 508 0.206212453943871 1033 1035021
SGTC_2072 5231554 129 µM 0.819458988242807 0.141783902345318 no 509 0.206262295810141 1108 789545
SGTC_227 fluconazole 33.516 µM 0.814997958746916 0.14291372867938 no 510 0.207536739256322 1048 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3076 9116187 49.47 µM 0.81466046700509 0.142999450685373 no 511 0.207633344129167 975 27241210
SGTC_1013 4112-3890 241 µM 0.813178171399159 0.143376361176609 no 512 0.208057956361091 952 705171
SGTC_1578 josamycin 24.2 µM 0.813089547472089 0.143398917244478 no 513 0.208083359430469 941 5282165 A P450 substrate.
SGTC_2614 arthonioic acid 13.39 µM 0.812498487997426 0.143549411680507 no 514 0.208252826910555 1005 6710684
SGTC_2889 9059656 51.95 µM 0.810051802631082 0.144173515818575 no 515 0.208955201718967 1058 3949838
SGTC_935 2996-0153 430 µM 0.808552358234601 0.144556899119872 no 516 0.209386338941814 1030 23738523
SGTC_2850 9015429 58.44 µM 0.808211037351929 0.144644265143922 no 517 0.209484552475178 1012 6457570
SGTC_1863 st057641 20.1 µM 0.807041035265574 0.144944014007094 no 518 0.209821420875537 1078 3921635
SGTC_3253 9135987 49.47 µM 0.805703200302466 0.145287272974015 no 519 0.210207001892503 971 4182430
SGTC_1216 1165-0504 9.65 µM 0.804921555364517 0.145488078757095 no 520 0.210432474356091 1040 6304004
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.798917841845271 0.147036663205414 no 521 0.212169026336718 1060 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1361 1608-0041 5.61 µM 0.798483282034072 0.147149179981614 no 522 0.212295045471729 1039 X1361
SGTC_3146 9095609 49.47 µM 0.797261966890764 0.147465713461292 no 523 0.212649451995046 1020 17173999
SGTC_1908 st060353 56.5 µM 0.794797255854521 0.14810589158215 no 524 0.213365723760695 1082 4227716
SGTC_853 0419-0306 21 µM 0.794573065813939 0.148164214302438 no 525 0.213430945530194 975 762713
SGTC_2219 9098279 200 µM 0.794169663676815 0.148269197494526 no 526 0.213548333268125 1059 902349
SGTC_905 2-aminofluorene 215 µM 0.793547932994017 0.148431096922123 no 527 0.213729327032211 1122 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3239 9133757 49.47 µM 0.793321777993577 0.148490017273564 no 528 0.213795185804654 1063 17036923
SGTC_2727 riluzole 51.77 µM 0.792008188198423 0.14883255713978 no 529 0.214177950918939 1043 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1322 1348-1070 12 µM 0.791173047709511 0.149050607947008 no 530 0.214421508542993 1042 6758089
SGTC_608 k048-0125 159 µM 0.790876515208465 0.149128082341188 no 531 0.214508027036693 1081 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_722 3534-0461 190 µM 0.789317453969876 0.149535857226717 no 532 0.214963243912349 1076 658262
SGTC_2974 9094440 9.66 µM 0.785193880367899 0.150617968163355 no 533 0.216169951466423 1061 25236134
SGTC_1868 st057644 42.7 µM 0.784141426864214 0.15089498702234 no 534 0.216478564808531 1100 688665
SGTC_2388 9080168 200 µM 0.783730131154966 0.151003337277292 no 535 0.216599239238069 1012 15943073
SGTC_103 0844-0104 51.839 µM 0.78061810637111 0.15182483551817 no 536 0.217513569628236 1132 5375804
SGTC_2415 st077333 57.7 µM 0.777747265250128 0.152585295597895 no 537 0.218359011015081 1126 2766255
SGTC_2951 9072950 58.06 µM 0.777634244010619 0.152615285525276 no 538 0.218392333612666 1136 16488155
SGTC_2348 9022543 33.42 µM 0.777330531127246 0.152695894416398 no 539 0.218481893257524 1052 3162678 YDL140C RPO21
SGTC_516 3992-2719 87.3 µM 0.776565111877109 0.152899170741322 no 540 0.218707695870009 1073 5350887 YDR037W KRS1
SGTC_3242 9133940 49.47 µM 0.773733502273569 0.153652734959444 no 541 0.219544201878062 1135 17248444
SGTC_576 1073-0113 22.7 µM 0.7725111168231 0.153978801816568 no 542 0.219905882623815 1267 5439563
SGTC_1339 1486-1321 22.7 µM 0.772438846347224 0.153998094026552 no 543 0.219927276791742 1055 3469382
SGTC_377 3970-0964 33.1 µM 0.769808092403342 0.154701448179466 no 544 0.220706869334531 1126 16481235
SGTC_575 k072-0246 11.9 µM 0.767073915332238 0.155434699345971 no 545 0.221518784884726 1096 6796779
SGTC_1068 loratadine 26.9 µM 0.766395853566428 0.155616896125918 no 546 0.221720399625248 1052 3957 A H1 histamine antagonist.
SGTC_2360 9040895 200 µM 0.765678095254975 0.15580991287604 no 547 0.221933931909098 1036 4914414
SGTC_1466 k213-0079 57.5 µM 0.765518951102653 0.155852730667612 no 548 0.221981293014318 1074 3657981
SGTC_1220 1838-0075 193 µM 0.765418957259395 0.155879638015242 no 549 0.222011054011694 1048 5529645
SGTC_1185 1319-0113 81.3 µM 0.763672464104823 0.156350095781132 no 550 0.222531227031619 1074 4672763
SGTC_2391 6285546 200 µM 0.763486655819058 0.156400202463602 no 551 0.222586608775935 1091 846083
SGTC_3106 9121286 49.47 µM 0.762465764886588 0.156675693471371 no 552 0.222891034182863 1092 15943471
SGTC_2638 epoxomicin 18 µM 0.761572446598395 0.156917020429257 no 553 0.223157612437047 1085 9915668 A protesome inhibitor.
SGTC_2434 5670830 169.91 µM 0.760999936703141 0.157071810590012 no 554 0.223328552527659 1054 1549830
SGTC_148 3253-0744 288.01 µM 0.760855777531286 0.157110802893988 no 555 0.223371607335877 1111 6893655
SGTC_646 4092-0839 27.3 µM 0.757984759308954 0.157888684281387 no 556 0.22423005333464 1129 877796
SGTC_2620 irigenin 100 µM 0.754021803162019 0.158966566075625 no 557 0.225418064897959 1118 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_271 rotenone 740 µM 0.7534088479894 0.159133712916161 no 558 0.225602133747411 1168 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_924 2046-0044 21.3 µM 0.752573543197205 0.159361677585341 no 559 0.225853110486711 1143 3623589
SGTC_2451 5856223 45.7 µM 0.751434827136119 0.159672791084958 no 560 0.226195504767403 1089 2179896
SGTC_418 lividomycin a 100 µM 0.751143248999125 0.159752518269646 no 561 0.226283224938777 1149 72394 An antibiotic.
SGTC_1160 4092-0570 10.5 µM 0.749166761055973 0.160293642520144 no 562 0.226878350203572 1099 4994975
SGTC_2797 7859098 81.82 µM 0.748729205071608 0.160413598671516 no 563 0.227010218620572 1136 972681
SGTC_1933 st074711 15.9 µM 0.748294868635759 0.160532730178251 no 564 0.227141159479183 1144 17250958
SGTC_1947 st076332 61.6 µM 0.747148668123807 0.160847392004464 no 565 0.227486912729051 1111 24208416
SGTC_385 1494-0393 12.4 µM 0.744647859937439 0.161535325555279 no 566 0.228242313532746 1097 3090647
SGTC_283 0987-0079 11.7 µM 0.744043688615726 0.161701810990248 no 567 0.228425022390936 1153 411556
SGTC_1441 4106-0040 13 µM 0.743519181564486 0.161846434794236 no 568 0.228583706409704 1132 2904180
SGTC_301 4119-0100 24.5 µM 0.743042112523414 0.161978051550342 no 569 0.228728092316456 1127 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_530 4358-1714 28 µM 0.742720154659891 0.16206691466821 no 570 0.228825562444682 1121 1564641
SGTC_273 hydroxyurea 18.1 mM 0.741683800103105 0.162353172920986 no 571 0.229139468627249 1199 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1215 3852-0577 11.2 µM 0.7392263774425 0.163033268278581 no 572 0.229884773130935 1188 2884876
SGTC_753 1322-0200 289 µM 0.738491577077977 0.163236984505906 no 573 0.230107891852137 1154 5403907
SGTC_1521 st012942 49.4 µM 0.737628279260129 0.163476536620275 no 574 0.23037018295102 1165 24207259
SGTC_2948 9070189 9.45 µM 0.737495010283654 0.163513537082742 no 575 0.230410688231264 1043 6473636 YDL196W YDL196W
SGTC_1444 4112-3581 28 µM 0.737139289980853 0.163612324999934 no 576 0.230518824040516 1141 2877249
SGTC_2475 5812728 15.03 µM 0.736960645579711 0.163661951368708 no 577 0.230573141047544 1165 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1694 st024011 44.9 µM 0.736720255163357 0.163728745840084 no 578 0.230646243277913 1196 2787533
SGTC_1805 st050013 60.3 µM 0.736376497109131 0.163824292608145 no 579 0.230750801889284 1079 4037144
SGTC_583 1488-1091 88.9 µM 0.735287526358675 0.16412720838932 no 580 0.231082201633405 1252 4303273
SGTC_723 4182-0001 115 µM 0.732944740317558 0.164780124969424 no 581 0.231796066890324 1101 744821 YLR208W SEC13
SGTC_944 3370-0224 231 µM 0.729082254013865 0.165860238763741 no 582 0.232975674568517 1169 4580514
SGTC_1129 3453-1384 223 µM 0.728951789230663 0.165896801931615 no 583 0.233015576785561 1161 1084452
SGTC_302 1094-0063 18.9 µM 0.728462702269642 0.166033916465441 no 584 0.233165196171931 1097 5440289
SGTC_1625 st003711 30.1 µM 0.728462506393369 0.16603397139362 no 585 0.233165256104242 1173 24207034 YER133W GLC7
SGTC_633 0437-0093 97.7 µM 0.727950200054857 0.166177673963267 no 586 0.233322035858096 1180 2831118
SGTC_308 4092-1169 104 µM 0.726836793589329 0.166490262827544 no 587 0.233662970323622 1144 2268590 YDL196W YDL196W
SGTC_2345 9052315 157.45 µM 0.726229724505416 0.166660857272382 no 588 0.233848976293242 1129 6469265
SGTC_2146 5545642 200 µM 0.726148795996552 0.166683607772587 no 589 0.233873778985452 1182 825326
SGTC_1308 1187-1617 41.4 µM 0.725672657441735 0.166817499702943 no 590 0.234019733811641 1172 2882570
SGTC_2084 5306078 60.6385 µM 0.725028203690019 0.166998832972224 no 591 0.234217364068717 1105 679340
SGTC_1279 0874-0590 65.2 µM 0.724484042491991 0.167152045354868 no 592 0.234384310211956 1142 3523074
SGTC_404 fumagillin 50 µM 0.72201994712694 0.167846962454553 no 593 0.235141106906003 1131 12015870 A methionine aminopeptidase binder.
SGTC_2504 purpurogallin 52.29 µM 0.721887343524364 0.167884411607101 no 594 0.235181871633264 1081 5281571 An antioxidant.
SGTC_1722 st034304 3.6505 µM 0.721537695649384 0.167983182952097 no 595 0.235289378375111 1181 4036148 YLR033W RSC58
SGTC_3093 9117344 49.47 µM 0.721412069800329 0.168018679883904 no 596 0.235328011362254 1101 24824913
SGTC_1820 st053765 18.6 µM 0.718192360256727 0.168930090440864 no 597 0.236319343938743 1151 3690829
SGTC_2220 6782180 200 µM 0.71807331648693 0.168963849205254 no 598 0.236356040950148 1104 833803
SGTC_2757 clomiphene 4.22 µM 0.717619606270258 0.169092553343246 no 599 0.236495932628429 1212 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2221 6807166 181.081 µM 0.717014703268007 0.169264244288467 no 600 0.236682512166815 1122 674925
SGTC_1366 1683-0113 21.9 µM 0.716565642116311 0.16939177465193 no 601 0.236821075355927 1178 708623
SGTC_704 1310-0270 142 µM 0.714637573452374 0.169940033829154 no 602 0.237416510605078 1161 5718033
SGTC_2252 omeprazole 400 µM 0.713937251431464 0.170139456396676 no 603 0.237632990669526 1101 4594 A proton pump inhibitor.
SGTC_682 0kpi-0099 17 µM 0.713438190156749 0.170281659752937 no 604 0.237787324079735 1198 1714895 YML126C ERG13
SGTC_424 splitomicin 100 mM 0.712291828606023 0.170608594170268 no 605 0.23814204151512 1144 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1454 4239-0054 42.6 µM 0.712264162716447 0.170616489254394 no 606 0.238150605723704 1222 1340767
SGTC_1033 k072-0102 21.3 µM 0.712151164227464 0.170648738344518 no 607 0.238185587107743 1154 5965931
SGTC_729 4092-0585 94.1 µM 0.711520544184109 0.170828785165967 no 608 0.238380862308221 1165 2169061
SGTC_3331 9141060 1.957 µM 0.71023999422129 0.171194765821617 no 609 0.238777661753537 1174 4906567 YPR165W RHO1
SGTC_1436 4092-1007 8.32 µM 0.710188976659522 0.171209356997709 no 610 0.238793477864171 1154 2881121
SGTC_440 fluspirilene 35.1 µM 0.707342555500155 0.172024701702439 no 611 0.239676812931941 1200 3396 An atypical antipsychotic.
SGTC_3090 9117696 49.47 µM 0.70520224775566 0.172639413228945 no 612 0.240342191345661 1147 7923821
SGTC_1124 fisetin 1.16336 µM 0.703763743471801 0.173053347786002 no 613 0.240789958090867 1147 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.699575193316496 0.174262214494899 no 614 0.242096319501232 1233 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1049 3226-0134 66 µM 0.698730320929922 0.174506703791157 no 615 0.242360290635385 1233 5702385
SGTC_1325 1431-0015 227 µM 0.698577638504218 0.174550910285839 no 616 0.242408011221993 1143 1103340
SGTC_1285 0929-0069 65.5 µM 0.698324693327672 0.174624161734773 no 617 0.242487079932017 1185 1206237
SGTC_1051 3253-3903 78 µM 0.697997602690931 0.174718914212706 no 618 0.24258934664966 1189 5509239
SGTC_2936 9038235 15.59 µM 0.697012236462631 0.175004554924447 no 619 0.242897568022274 1207 4749415
SGTC_1666 st014829 29 µM 0.696924377352209 0.175030038147461 no 620 0.242925060531334 1221 3858230
SGTC_1340 1486-1359 257 µM 0.695743407365911 0.175372802774923 no 621 0.243294768120675 1164 4309068
SGTC_801 0866-0028 10.1 µM 0.693229682283163 0.176103801953831 no 622 0.244082711771882 1232 6849771
SGTC_1730 st033808 45.1 µM 0.689937328093845 0.177064141932963 no 623 0.245116800131684 1208 1045166
SGTC_1935 st074532 41.6 µM 0.688550174585082 0.17746974665547 no 624 0.245553192620166 1269 2829742
SGTC_902 1120-0002 2.07 µM 0.687822367816713 0.177682792300588 no 625 0.245782324302002 1204 3280475
SGTC_3311 9131146 2.8755 µM 0.687820821790278 0.177683245029486 no 626 0.245782811151737 1183 4900406 YPR165W RHO1
SGTC_546 peri-Naphthalide 147 µM 0.686969957114236 0.177932517444702 no 627 0.246050830276364 1168 223824 A penicillin ester.
SGTC_3278 9139605 49.47 µM 0.686475963499662 0.178077340751095 no 628 0.246206508287101 1230 7958859
SGTC_899 1083-0020 478 µM 0.685871027489912 0.178254790050599 no 629 0.24639722079678 1243 767123
SGTC_126 0417-1624 672.48 µM 0.685635688227604 0.178323853545251 no 630 0.246471435387712 1305 41912 YDL195W SEC31
SGTC_3191 9110352 49.47 µM 0.684619483360797 0.178622266185682 no 631 0.246792034601521 1196 17122424
SGTC_90 0870-0863 4.608 µM 0.684585336174129 0.178632299102198 no 632 0.246802811463625 1206 1738164
SGTC_2927 9011802 47.9 µM 0.684398436608156 0.178687219070394 no 633 0.246861801484209 1198 43912568
SGTC_3171 9103192 49.47 µM 0.683266914151876 0.179019941085468 no 634 0.247219098418857 1253 13018434
SGTC_353 1988-1175 58.3 µM 0.682452002068642 0.179259805730788 no 635 0.247476591581357 1133 2788357
SGTC_3272 9137413 49.47 µM 0.677674465274171 0.180670108853273 no 636 0.248989060034718 1189 17614870
SGTC_2445 5742597 35.57 µM 0.674492806142834 0.181613166024067 no 637 0.249999028892716 1189 1774255
SGTC_2382 9035899 200 µM 0.674354711202409 0.181654167579033 no 638 0.250042914182792 1262 6462679
SGTC_675 1309-0189 238 µM 0.673951341726086 0.181773964551426 no 639 0.250171124660197 1203 4246530
SGTC_867 0518-0118 155 µM 0.666195535977865 0.184086969897073 no 640 0.252643062938039 1276 6848158
SGTC_1004 4084-0029 199 µM 0.665450467701492 0.184310131327447 no 641 0.252881207330173 1253 716894 YLR208W SEC13
SGTC_330 1488-0319 80.1 µM 0.664841819989286 0.184492557196096 no 642 0.25307583559265 1243 6846614
SGTC_2127 5253358 187.912 µM 0.664760210336821 0.184517026042086 no 643 0.253101938033177 1196 20612
SGTC_2262 9014885 67.46 µM 0.664661476865972 0.184546631783553 no 644 0.253133519334644 1186 6457424
SGTC_1387 3342-1166 1.8 µM 0.658844188736386 0.186296187744607 no 645 0.254997914074988 1240 3418228
SGTC_1583 clindamycin 39.6 µM 0.657235019116758 0.186781956027726 no 646 0.255514905819425 1192 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3250 9135583 49.47 µM 0.655690242195915 0.187249022590702 no 647 0.256011724240104 1282 7699353
SGTC_2087 5276107 200 µM 0.654942506959169 0.187475361072867 no 648 0.256252385559609 1238 144405
SGTC_1609 st001574 46.4 µM 0.652754762499652 0.188138558983139 no 649 0.256957195866924 1247 3960012
SGTC_2142 5622915 118.518 µM 0.650129563010783 0.188936276457564 no 650 0.257804267296634 1245 5322196
SGTC_2206 7254556 146.969 µM 0.649524261490827 0.189120504201168 no 651 0.257999784948066 1254 4398905
SGTC_1797 st048695 56.8 µM 0.648982297685664 0.189285548504162 no 652 0.258174909206168 1245 592262 YIL048W NEO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.648449811359646 0.189447792958196 no 653 0.258347031015279 1303 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1902 st060212 70.5 µM 0.64842715764338 0.189454697267255 no 654 0.25835435496048 1282 688944
SGTC_1645 Cervolide 78 µM 0.647908508224324 0.189612811516416 no 655 0.258522063711867 1216 23173 A fragrance.
SGTC_1088 bifonazole 369 nM 0.646332038615043 0.190093908523773 no 656 0.259032171617971 1224 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3126 9127922 49.47 µM 0.646262321992588 0.190115201507269 no 657 0.259054742264121 1301 45595682
SGTC_1073 triclabendazole 3.09 µM 0.646244038990487 0.190120785779138 no 658 0.259060661525425 1312 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1667 st014849 34.6 µM 0.645913483625584 0.190221766398286 no 659 0.259167693406613 1293 5348460
SGTC_71 0417-1750 47.813 µM 0.645552734844614 0.190332008332903 no 660 0.259284527819508 1270 6811472
SGTC_1798 st045719 60.953 µM 0.64500086866953 0.190500730127631 no 661 0.259463311388838 1213 3980186
SGTC_2022 5136654 200 µM 0.644214498188355 0.190741305417772 no 662 0.259718175358481 1276 1713771
SGTC_2174 5790901 200 µM 0.643186750510734 0.191056006458259 no 663 0.260051464751349 1279 786020
SGTC_1064 honokiol 6.76 µM 0.642328705204888 0.191318987597418 no 664 0.260329889996158 1271 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_560 2332-1943 155 µM 0.640747764562359 0.191804108571175 no 665 0.260843287827519 1274 21177716
SGTC_2702 st077768 96.8 µM 0.640239424208814 0.191960255690026 no 666 0.26100847788074 1214 6484119
SGTC_2956 9076196 2.52 µM 0.640199297325612 0.191972584793813 no 667 0.261021519784837 1322 16423868
SGTC_2320 7373003 200 µM 0.63972576992771 0.192118114092957 no 668 0.261175449362901 1268 5415828
SGTC_1131 3454-3128 32.3 µM 0.639413516763916 0.192214115860089 no 669 0.261276979033938 1374 710982
SGTC_155 k072-0202 43.6 µM 0.639211541907164 0.19227622835377 no 670 0.261342662315635 1232 5857737
SGTC_918 glabranin 770.725 nM 0.638454935558125 0.192509013487917 no 671 0.261588790039261 1313 124049 Also referred to as licorice root.
SGTC_1378 2093-0007 380 nM 0.637943031627343 0.192666608682527 no 672 0.261755382331108 1293 3618014
SGTC_214 4373-3496 70 µM 0.637752954030667 0.19272514620556 no 673 0.261817254398697 1354 3779166
SGTC_379 3970-0972 5.9 µM 0.636917698746518 0.192982505588029 no 674 0.262089226827931 1292 2898042 YBL034C STU1
SGTC_1126 isoteolin 1.0172 µM 0.636685397194614 0.19305411977319 no 675 0.262164893642242 1270 133323
SGTC_765 1319-0117 244 µM 0.635934211095161 0.193285807325054 no 676 0.262409651599496 1253 3487746 YGL099W LSG1
SGTC_1964 st076914 61 µM 0.635489823500916 0.19342294918201 no 677 0.262554500874502 1290 24208661
SGTC_334 1502-1024 68.5 µM 0.634772497125073 0.193644447526754 no 678 0.262788401557134 1307 3296216
SGTC_2225 6654152 15.4 µM 0.633270760937946 0.194108659051052 no 679 0.26327842188388 1262 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1904 st060225 78 µM 0.63257800366517 0.194323030093079 no 680 0.263504627524558 1272 66595
SGTC_914 3820-6779 408 µM 0.63055436748113 0.194950061532612 no 681 0.264165971905524 1272 2893481
SGTC_1511 0906-3109 28.5 µM 0.628012007056308 0.195739563053331 no 682 0.264998037160185 1329 2882180
SGTC_2266 7929956 200 µM 0.627026999441406 0.196045967000068 no 683 0.265320768577127 1294 2967153
SGTC_3332 9141069 11.198 µM 0.626291450792519 0.196274961978341 no 684 0.265561896415544 1260 17332883
SGTC_2768 sulfasalazine 50.2 µM 0.624698240724135 0.196771524464649 no 685 0.266084564002115 1387 5384001 An antioxidant and salicylic acid derivative.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.623494616043436 0.197147167240013 no 686 0.266479769589644 1255 2333 A French combination drug.
SGTC_1772 st048439 82.2 µM 0.622318695876908 0.197514582370056 no 687 0.266866165037387 1282 2927068 YDL195W SEC31
SGTC_2200 6600604 21.907 µM 0.62202412794826 0.197606684637616 no 688 0.266963001389846 1268 2904777
SGTC_2998 9066762 71.4286 µM 0.621761815566501 0.197688723443096 no 689 0.267049248980512 1362 4945196
SGTC_2751 anetholtrithion 17.25 µM 0.62051667075256 0.198078426047418 no 690 0.267458840990216 1295 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_203 k066-0004 30.888 µM 0.617410135091382 0.199052722898731 no 691 0.268482119340021 1383 6795412
SGTC_1862 st057513 3.81 µM 0.616896954109778 0.199213948314454 no 692 0.268651347994373 1298 5393163
SGTC_2257 7960413 200 µM 0.616815824790015 0.199239443807666 no 693 0.268678106435665 1296 2974689 YIL048W NEO1
SGTC_3040 9091894 49.47 µM 0.615327710794191 0.199707443246393 no 694 0.269169160395981 1255 25236966
SGTC_52 0329-0193 875 nM 0.614068083811378 0.200104101807204 no 695 0.269585168850708 1383 3739292
SGTC_179 1273-0063 6.77 µM 0.612110996585962 0.200721330384067 no 696 0.270232161227752 1283 3108139
SGTC_1489 4065-0444 182 µM 0.61137257388988 0.200954511667994 no 697 0.270476477569028 1301 2877968
SGTC_1845 st056753 3.01 µM 0.607984067036883 0.202026626612182 no 698 0.27159902063611 1266 5375839
SGTC_62 0180-0423 3.232 µM 0.607634665169193 0.202137370832187 no 699 0.271714902133409 1295 30102 YGL099W LSG1
SGTC_492 tmb-8 126 µM 0.607420996536034 0.202205111793752 no 700 0.271785778908331 1250 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2817 7995342 71.43 µM 0.606349601766106 0.202544988809696 no 701 0.272141313715647 1279 18879975
SGTC_836 0330-0104 1.35 µM 0.606322656342263 0.202553541067692 no 702 0.272150258344261 1340 46494820
SGTC_949 1165-0505 146 µM 0.604164626822569 0.203239182781103 no 703 0.272867098037621 1326 6244267
SGTC_2626 ethyl orsellinate 100 µM 0.603910976338422 0.203319862616733 no 704 0.272951415408579 1314 75653 A natural product.
SGTC_2518 prenyletin 46.28 µM 0.602614478625038 0.203732544323153 no 705 0.273382593109544 1277 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2879 9041815 71.43 µM 0.602082416572914 0.203902046750971 no 706 0.273559639139495 1289 4942971
SGTC_3189 9110682 49.47 µM 0.601127229511005 0.20420655761933 no 707 0.273877624217965 1373 17122418
SGTC_2771 fluoxetine 41.05 µM 0.597218718120625 0.205455398184436 no 708 0.275180681834389 1373 3386 A selective serotonin reuptake inhibitor.
SGTC_1011 4112-3381 17.4 µM 0.596465552324568 0.205696568500504 no 709 0.27543212992489 1386 2877139
SGTC_1668 st014914 51.6 µM 0.595775434155685 0.205917697850039 no 710 0.27566262845258 1342 2839556
SGTC_2138 5575593 77.673 µM 0.594293321347701 0.206393076414793 no 711 0.276157972404695 1325 762213
SGTC_3230 9131665 49.47 µM 0.593246159568679 0.206729338806431 no 712 0.276508212498128 1303 15943720
SGTC_1096 rimcazole 32.2 µM 0.589974594188346 0.20778198469959 no 713 0.277603841180702 1299 18528119 A dopamine reuptake inhibitor.
SGTC_2659 sanguinarine 24.21 µM 0.589482656211955 0.207940542071374 no 714 0.277768771681656 1308 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_961 1252-1571 372 µM 0.587281331872132 0.208650929258672 no 715 0.278507388357801 1425 6813498
SGTC_2687 chenodiol 100 µM 0.587141816555374 0.208696000261656 no 716 0.278554232555034 1399 5702181 A cholesterol synthesis inhibitor.
SGTC_730 1436-0052 41.2 µM 0.587105695029702 0.208707670405764 no 717 0.278566361482282 1357 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1094 duloxetine 25.4 µM 0.584178475523807 0.209654674516294 no 718 0.279550120713657 1357 60834 A selective serotonin reuptake inhibitor.
SGTC_32 0928-0142 34.1 µM 0.583570659128827 0.209851629569777 no 719 0.279754602632648 1322 2244242
SGTC_1027 k015-0025 8.67 µM 0.58348580041082 0.209879135590879 no 720 0.279783156620378 1335 3598955
SGTC_3280 9140961 49.47 µM 0.582765597323873 0.210112666807738 no 721 0.28002555362565 1345 4901226
SGTC_2028 5153890 36.43 µM 0.580649304964745 0.210799773068118 no 722 0.280738417521902 1335 2830968 YPR165W RHO1
SGTC_507 nimesulide 162 µM 0.57947514491151 0.211181560690592 no 723 0.281134306438761 1415 4495 A COX2 inhibitor.
SGTC_2816 7982706 58.44 µM 0.579311536021795 0.211234791586717 no 724 0.281189491478944 1360 2981853
SGTC_632 0781-2353 4.65 µM 0.579299187469289 0.211238809563458 no 725 0.281193656840024 1404 6811515 YHR007C ERG11
SGTC_2327 6189656 200 µM 0.578962471128701 0.21134838771182 no 726 0.281307248042639 1446 5349088
SGTC_170 4197-0004 226 µM 0.578873278474915 0.211377419399708 no 727 0.281337340880338 1402 218692
SGTC_2866 9034245 58.44 µM 0.577691273912209 0.211762375511512 no 728 0.281736285771788 1364 6462273
SGTC_2280 7785178 200 µM 0.57704852287401 0.211971879225636 no 729 0.28195333863148 1386 2954328
SGTC_1697 st025554 27.742 µM 0.576662406348488 0.212097791579915 no 730 0.282083766397004 1342 1269519
SGTC_159 3970-0959 50 µM 0.575646434703025 0.21242930814256 no 731 0.282427094033489 1429 6615653
SGTC_3028 9087778 49.47 µM 0.57560463208107 0.212442955025907 no 732 0.282441224711131 1304 17217395
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.575546106968564 0.212462061993787 no 733 0.282461008718435 1403 5393153
SGTC_1943 st076331 65.2 µM 0.574297340608222 0.212869991794996 no 734 0.282883304241389 1401 24208415
SGTC_1390 3413-2614 145 µM 0.57320667615944 0.213226648734984 no 735 0.283252382286309 1370 3421432
SGTC_1391 3442-0225 151 µM 0.571471701602283 0.213794718285683 no 736 0.283839968708442 1374 5227075
SGTC_368 fentichlor 4.58 µM 0.56961440625782 0.214403814076834 no 737 0.28446962762736 1353 7329 A pesticide.
SGTC_831 k061-1017 217 µM 0.569371065805739 0.214483691726635 no 738 0.284552174144379 1435 1240153
SGTC_2403 6032726 181.2 µM 0.568674157066599 0.21471255101526 no 739 0.284788644429407 1389 2881040
SGTC_3082 9117008 49.47 µM 0.568589771323047 0.214740272250804 no 740 0.284817283983807 1379 41448529
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.568450892589769 0.214785899295914 no 741 0.284864420826226 1433 5377381
SGTC_3275 9138069 49.47 µM 0.567601139145668 0.215065198870662 no 742 0.285152916736699 1407 17617007
SGTC_1848 st056003 16.4 µM 0.566826538533207 0.215319980607671 no 743 0.285416019117782 1421 146492
SGTC_1597 7-benzyloxygramine 47.5 µM 0.565628960939093 0.215714232502526 no 744 0.285823018072774 1384 260807
SGTC_772 k072-0172 35.3 µM 0.565289712473241 0.21582599176435 no 745 0.285938362435147 1306 5861980
SGTC_2260 7964312 200 µM 0.56522336638039 0.215847852205252 no 746 0.285960922670549 1455 231951
SGTC_1801 st050089 28.441 µM 0.563855430973385 0.216298860514291 no 747 0.286426262021918 1392 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_414 piperonyl butoxide 100 µM 0.563612623528956 0.216378971101713 no 748 0.286508896925917 1355 5794 A potent inhibitor of cytochrome P450.
SGTC_972 1319-0219 195 µM 0.562652057810015 0.216696063313565 no 749 0.286835918068639 1348 23903702
SGTC_1426 4048-4480 71.7 µM 0.561900925573189 0.216944206603824 no 750 0.287091761520542 1435 14224343
SGTC_13 0199-0087 65 µM 0.561124284780348 0.217200949494827 no 751 0.287356407019358 1420 4589825
SGTC_1723 st034307 2.5525 µM 0.560183741302064 0.217512110401238 no 752 0.287677057875923 1404 867466
SGTC_903 1134-0042 114 µM 0.559779018593668 0.217646084347068 no 753 0.287815088289781 1380 701009
SGTC_1767 st044992 70.3 µM 0.558418955497263 0.218096650002105 no 754 0.288279165967562 1344 9600693
SGTC_2855 9016525 58.44 µM 0.557903104207509 0.218267683246523 no 755 0.288455275847372 1360 43811474
SGTC_3281 9140613 49.47 µM 0.557809393380919 0.218298761862866 no 756 0.288487273847255 1301 16013766
SGTC_1831 st055328 12 µM 0.557155366093402 0.218515736945564 no 757 0.288710641085956 1441 1103068
SGTC_1776 st049249 45.9 µM 0.557117081235783 0.218528441882818 no 758 0.288723718878113 1364 1822314
SGTC_2610 ononetin 44.17 µM 0.556530852381834 0.218723036683569 no 759 0.288924004656983 1376 259632
SGTC_3002 9075603 71.4286 µM 0.556161685861705 0.21884563023292 no 760 0.289050164373242 1368 20105405
SGTC_818 4072-2707 53.5 µM 0.554045947086535 0.219548991082323 no 761 0.289773700550101 1344 882871
SGTC_2796 7949634 45.45 µM 0.554001834584529 0.21956366974419 no 762 0.289788795095782 1374 2971588
SGTC_2735 sertaconazole 140 nM 0.552890750228513 0.219933574629709 no 763 0.290169110814535 1464 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1457 k015-0032 57.3 µM 0.55211557547469 0.220191859322493 no 764 0.290434585654021 1402 4302660
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.55110469690688 0.220528940636602 no 765 0.290780952917355 1345 6708514
SGTC_3007 9078383 71.4286 µM 0.550790473554319 0.220633779821299 no 766 0.290888657689202 1409 6496995
SGTC_183 3914-0051 30.55 µM 0.550131041897942 0.220853888984827 no 767 0.291114748394269 1489 1596232
SGTC_805 3852-0218 479 µM 0.547818102484176 0.221626909250009 no 768 0.291908403696419 1368 6615355
SGTC_2211 7117706 200 µM 0.547382924528126 0.221772525114081 no 769 0.292057841958052 1439 822771
SGTC_1449 4112-4002 201 µM 0.546930433665239 0.221923992032021 no 770 0.292213263152571 1331 2059539
SGTC_1626 st003712 1.76 µM 0.546514286919194 0.222063345243425 no 771 0.292356234857791 1435 24207035
SGTC_2874 9043904 71.43 µM 0.546402602678875 0.222100752948859 no 772 0.292394610719371 1394 4463428
SGTC_927 2425-1185 123 µM 0.546310075067879 0.222131747025181 no 773 0.292426405938584 1371 730375
SGTC_1347 1493-0251 600 nM 0.54272589180185 0.223334243328399 no 774 0.293659272260533 1458 3986378
SGTC_2580 diallyl disulphide 81.36 µM 0.542225309094663 0.223502483542493 no 775 0.293831651064719 1444 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2734 clemastine 41.6 µM 0.540791881213567 0.223984641103603 no 776 0.294325519719768 1424 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_490 phenamil 164 µM 0.535827833738451 0.225658941216987 no 777 0.296038771888658 1479 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2507 purpurin 79.67 µM 0.53518783868656 0.225875316266051 no 778 0.296259987441457 1370 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_219 mitoxanthrone 164.414 µM 0.534861074049145 0.225985836901933 no 779 0.296372963511601 1460 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_584 0986-0246 15.4 µM 0.53428178655348 0.226181842716448 no 780 0.296573295722373 1508 53315 YDR232W HEM1
SGTC_2241 6772625 37.8075 µM 0.534109115518407 0.226240285699662 no 781 0.296633021715946 1383 2285411
SGTC_3138 9097216 49.47 µM 0.533464348007537 0.226458591885367 no 782 0.296856092049862 1410 25237486
SGTC_711 k292-0785 179 µM 0.533330674925777 0.226503865965376 no 783 0.296902348556788 1412 4146315
SGTC_946 3434-1334 87.4 µM 0.533282075769306 0.226520327405376 no 784 0.296919166725885 1482 4047976
SGTC_1017 4239-0030 168 µM 0.52940201782396 0.22783675305678 no 785 0.298263299354386 1391 1149593
SGTC_2877 9040724 71.43 µM 0.529189157080438 0.227909096778809 no 786 0.298337118839419 1521 6463895
SGTC_2089 5281248 129.67 µM 0.528068943492565 0.228290030044973 no 787 0.298725742624542 1432 2737878
SGTC_3011 9081274 71.4286 µM 0.527759192404884 0.228395425308488 no 788 0.298833241873846 1427 6625322
SGTC_2000 st075254 36.4 µM 0.524547824412344 0.22948972854295 no 789 0.299948782786913 1416 17234175
SGTC_1674 st016616 23.6 µM 0.524529463192605 0.229495993733515 no 790 0.299955166384923 1393 625830
SGTC_1879 gemcitabine 100 µM 0.52421769371298 0.229602389923032 no 791 0.300063567861053 1455 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1432 4049-0298 68.4 µM 0.523687706300042 0.2297833197777 no 792 0.300247883828538 1514 741646
SGTC_187 1488-2104 32.728 µM 0.519777465036445 0.231120682880632 no 793 0.3016093438022 1529 2852859
SGTC_1406 3909-7906 11.9 µM 0.5185066393259 0.231556258377698 no 794 0.302052414486891 1472 X1406
SGTC_1662 st014054 52 µM 0.517951185198107 0.231746783888474 no 795 0.302246164140824 1437 2838777
SGTC_2598 perillyl alcohol 100 µM 0.517056761618123 0.232053762293381 no 796 0.302558267910373 1507 10819 An apoptosis inducer.
SGTC_1362 1611-0397 101 µM 0.516735095485479 0.232164217830776 no 797 0.302670546693731 1441 27816
SGTC_1416 3966-0321 25.3 µM 0.516094251300451 0.232384361729005 no 798 0.302894291410147 1447 582530 YLR208W SEC13
SGTC_2836 9010338 19.48 µM 0.515839216576605 0.23247200398556 no 799 0.302983354975956 1327 2994051
SGTC_432 NS 1619 61.3 µM 0.515614234639532 0.23254933391001 no 800 0.303061933195564 1467 4552 A K+/calcium channel activator.
SGTC_3223 9129970 49.47 µM 0.514576603350623 0.232906169569144 no 801 0.303424458970894 1512 17248386
SGTC_1111 tnp00062 510.699 nM 0.514508381455728 0.232929641352902 no 802 0.303448301001888 1578 676306
SGTC_1907 st060210 83.7 µM 0.514275203504866 0.233009876285759 no 803 0.303529797814197 1537 688793
SGTC_532 1548-0774 215 µM 0.51258898956167 0.233590547516749 no 804 0.304119428358782 1567 5932993
SGTC_2210 7115885 190.385 µM 0.512555338916708 0.233602143745192 no 805 0.304131200414667 1451 2927039
SGTC_286 k060-0067 22.9 µM 0.511269668628911 0.234045432988183 no 806 0.304581120372872 1439 5985051
SGTC_1864 st057645 30.4 µM 0.507859530200324 0.235223476257458 no 807 0.305775928910445 1488 688666
SGTC_408 cantharidin 100 µM 0.507522107563938 0.235340217737616 no 808 0.305894264283531 1472 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_642 0335-0876 158 µM 0.506570025337605 0.235669791509419 no 809 0.306228272297044 1497 6812350
SGTC_1376 2910-0861 41.3 µM 0.505399766004324 0.236075238194834 no 810 0.306639041588662 1510 1112859
SGTC_248 streptozotocin 5.23457 mM 0.502881338011889 0.236949071788104 no 811 0.307523851289805 1564 5300 DNA alkylating agent.
SGTC_2064 5220758 200 µM 0.502304233688868 0.237149563130726 no 812 0.307726765799303 1505 788518
SGTC_521 r062-0005 13.8 µM 0.501651325980567 0.237376501590189 no 813 0.307956404312815 1466 2832033
SGTC_474 dl-dihydrosphingosine 5 µM 0.501609376574937 0.2373910864915 no 814 0.307971161190036 1516 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_644 1498-1197 63.3 µM 0.501442934827326 0.237448959536966 no 815 0.308029714791994 1529 6741615
SGTC_1067 clotrimazole 1.36 µM 0.500493486455497 0.237779237925942 no 816 0.308363820695585 1475 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2306 7482397 179.52 µM 0.499891102074962 0.237988916015471 no 817 0.308575878953257 1604 891448
SGTC_188 3229-0966 278.469 µM 0.499593101815525 0.23809268147431 no 818 0.308680808037822 1589 5722370
SGTC_1314 1222-0010 41.1 µM 0.498961312532104 0.238312756236663 no 819 0.308903319477764 1489 3526027
SGTC_2115 tiliquinol 12.7705 µM 0.497667623396321 0.238763741797466 no 820 0.309359165905262 1506 71208 A bioactive hydroxyquinoline.
SGTC_3134 9127454 49.47 µM 0.49765375950918 0.238768577335017 no 821 0.309364052598263 1540 24262820
SGTC_906 1165-0455 526 µM 0.497052460529899 0.238978353882369 no 822 0.309576028729103 1450 3252859
SGTC_992 3909-8734 162 µM 0.495248994323437 0.239608137192191 no 823 0.31021218507174 1473 4288319
SGTC_2691 st077356 60.2 µM 0.495005654397995 0.239693182546622 no 824 0.310298064581729 1582 2839272
SGTC_2247 cerulenin 830 nM 0.493540844822386 0.240205469624048 no 825 0.310815243511523 1546 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2412 st077135 33.4 µM 0.492488840312549 0.240573754440722 no 826 0.311186904565833 1567 13258915
SGTC_814 3342-0569 96 µM 0.492034572344117 0.240732879158311 no 827 0.311347451757636 1521 4346283
SGTC_1699 st031318 29.054 µM 0.491834808441136 0.24080287222845 no 828 0.311418063593685 1549 5340658
SGTC_3215 9129942 49.47 µM 0.490597194290116 0.241236752902073 no 829 0.311855685614579 1504 17682944
SGTC_1072 oxiconazole 14.9 nM 0.487083940267077 0.242470735196662 no 830 0.313099423420798 1525 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_590 k048-0076 22.4 µM 0.485673349746496 0.242967146088061 no 831 0.313599390880126 1567 6832814
SGTC_1389 3405-0187 19 µM 0.48546798658124 0.243039462711914 no 832 0.313672208064629 1457 799890
SGTC_2054 5233173 129 µM 0.48357832826564 0.243705433415653 no 833 0.314342579080542 1540 6889
SGTC_2778 tioconazole 65.09 nM 0.483037126331274 0.243896350094001 no 834 0.314534687663482 1457 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3224 9130643 49.47 µM 0.481203138885411 0.244543914941606 no 835 0.315186065101214 1561 17644395
SGTC_2136 5328288 199.296 µM 0.481120542273932 0.244573100857581 no 836 0.315215414491278 1474 262395
SGTC_2642 cholecalciferol 100 µM 0.479262476023593 0.24523015318614 no 837 0.315875956675433 1541 9821465 A vitamin D precursor, similar to steriods.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.477211051913289 0.245956681945396 no 838 0.316605920990332 1527 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_272 doxorubicin 8.13 µM 0.476079374451377 0.246357968618404 no 839 0.31700891527765 1513 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2780 5215298 71.43 µM 0.474475127047216 0.24692742682013 no 840 0.317580565422726 1608 2834131
SGTC_3141 9094609 49.47 µM 0.473618248929938 0.24723188041601 no 841 0.317886079849247 1458 25236309 YDL196W YDL196W
SGTC_752 1896-0090 130 µM 0.473072478676772 0.247425900231573 no 842 0.318080735410834 1519 772567
SGTC_1949 st076024 69.1 µM 0.471323432041346 0.248048229328973 no 843 0.318704892481149 1468 2921930
SGTC_1349 flufenamic acid 69 µM 0.471081333730418 0.248134436190345 no 844 0.318791327206534 1494 3371 A non-steroidal anti-inflammatory.
SGTC_577 r071-0003 38.6 µM 0.469480913186333 0.248704718978276 no 845 0.319362962351768 1509 4568517 YMR134W ERG29
SGTC_733 4069-0007 56.1 µM 0.46920813208943 0.248801989483324 no 846 0.31946043667137 1556 5717425 YNL287W SEC21
SGTC_1204 4049-0315 18.3 µM 0.468797889659108 0.24894831519765 no 847 0.319607054270025 1642 588402
SGTC_1712 st032288 53.4 µM 0.46869918974945 0.248983526421865 no 848 0.319642333094152 1491 2883011
SGTC_3053 9095903 49.47 µM 0.468665176202535 0.248995661379548 no 849 0.319654491111989 1573 17174018
SGTC_145 3737-0113 38.366 µM 0.468588621521936 0.249022974819381 no 850 0.319681856011324 1599 6849351
SGTC_1856 st057054 55.7 µM 0.46686543865157 0.249638199441744 no 851 0.320298076877686 1638 1266018
SGTC_102 gallobenzophenone 83.616 µM 0.466115509608583 0.249906197062416 no 852 0.320566411115623 1608 70837
SGTC_421 streptovitacin 30 mM 0.465043084434119 0.250289708352329 no 853 0.320950301582475 1544 91467 include heat shock
SGTC_2871 9038510 12.99 µM 0.464831637996667 0.250365360784975 no 854 0.321026014577159 1661 4945164
SGTC_1680 diphenhydramine 100 µM 0.464493988688099 0.250486191881085 no 855 0.321146932683125 1526 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2277 7947813 106.88 µM 0.46421755512415 0.250585139327646 no 856 0.321245942483596 1632 1246798
SGTC_454 lyso-paf C-16 6.67 µM 0.463954692817772 0.250679248241411 no 857 0.321340103272804 1434 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_413 propylparaben 100 µM 0.463925214065775 0.250689803273735 no 858 0.321350663671777 1486 7175 A pharmaceutical preservative.
SGTC_1218 1348-1416 30.7 µM 0.463079490942614 0.250992719390709 no 859 0.321653695019036 1536 6787668
SGTC_1313 1220-0047 237 µM 0.463048803004585 0.251003714655625 no 860 0.321664693057594 1593 3528706
SGTC_467 ro 31-8220 72.8 µM 0.461308508432287 0.251627666369656 no 861 0.322288640716543 1585 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_363 0455-0021 3.06 µM 0.461295274097352 0.251632414442315 no 862 0.322293387543251 1546 4597466
SGTC_3254 9136651 49.47 µM 0.460168619862417 0.252036796798211 no 863 0.322697596566044 1506 16454030
SGTC_129 0088-0017 176.636 µM 0.46011621627506 0.252055614003351 no 864 0.322716402472511 1604 182446
SGTC_2536 dehydroabietamide 32.04 µM 0.458113560155019 0.252775287597101 no 865 0.323435428626877 1661 3983547
SGTC_3192 9110362 49.47 µM 0.456268142591158 0.253439412581437 no 866 0.324098584768384 1587 16649480
SGTC_529 4076-0302 30.3 µM 0.456203951668871 0.253462529966832 no 867 0.324121662025789 1528 5816522
SGTC_2900 5328528 85.29 µM 0.455421283883619 0.253744484975298 no 868 0.324403092996156 1481 795359
SGTC_2569 tetrandrine 100 µM 0.455386772201183 0.253756921552078 no 869 0.32441550498615 1482 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2926 9010726 65.15 µM 0.455095045977015 0.253862060350611 no 870 0.324520430960499 1499 2994293
SGTC_455 paf C-16 10 µM 0.45490646136739 0.253930038841593 no 871 0.324588267120512 1541 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_493 zm226600 134 µM 0.452879932909669 0.25466113753587 no 872 0.325317600765721 1565 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2820 7989630 71.43 µM 0.450020681735743 0.255694524496202 no 873 0.326347763999252 1579 2984098
SGTC_1631 benzylvanillin 81.9 µM 0.449640722327309 0.255832013579878 no 874 0.326484760044534 1578 75506
SGTC_2401 5128683 200 µM 0.449272061341509 0.255965451180352 no 875 0.326617704767132 1475 708373
SGTC_1688 st021091 57.6 µM 0.44877274103831 0.256146239071026 no 876 0.326797802322821 1657 3656366
SGTC_854 0422-0053 192 µM 0.448543396368953 0.256229299741693 no 877 0.326880537131139 1523 3596728
SGTC_553 k007-0256 45.7 µM 0.447861362545933 0.25647639164271 no 878 0.327126627301589 1573 6287000
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.447377061784243 0.256651922793534 no 879 0.327301417449856 1526 4330530
SGTC_1167 k781-0610 148 µM 0.446667299860577 0.25690928361106 no 880 0.327557647744859 1566 4525169
SGTC_296 1222-0039 74.9 µM 0.445329992017573 0.257394558205842 no 881 0.328040648303703 1508 5984176
SGTC_2543 pimpinellin 60.67 µM 0.443380049689798 0.258102994697673 no 882 0.328745431845666 1514 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_218 alverine citrate 93.75 µM 0.442331091084666 0.258484511253779 no 883 0.329124817804589 1607 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2369 9071472 200 µM 0.442092505013261 0.258571328110755 no 884 0.329211133889064 1621 17296037
SGTC_1084 voriconazole 435 nM 0.442062711598959 0.258582170418414 no 885 0.329221913241937 1601 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1659 st012954 42.1 µM 0.441768888192802 0.258689110138972 no 886 0.329328227095749 1588 24207262
SGTC_2497 7-hydroxyflavone 100 µM 0.441405950356661 0.25882123628793 no 887 0.329459567611455 1623 5281894
SGTC_1191 1487-1166 10.6 µM 0.439362433738754 0.259565822104188 no 888 0.330199471016008 1640 3955771
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.438382350406686 0.259923322141511 no 889 0.330554569278523 1608 279621
SGTC_31 0508-1974 57.237 µM 0.438046862172724 0.260045754808194 no 890 0.330676156554786 1610 6810525
SGTC_369 0957-0393 4.5 µM 0.436211390760494 0.260716115482805 no 891 0.331341682114936 1526 6997992
SGTC_1006 4099-6547 255 µM 0.435894553693604 0.260831922345776 no 892 0.331456618410503 1601 3146833
SGTC_338 4055-0136 114 µM 0.435156089648486 0.261101940424749 no 893 0.331724566351034 1533 2900563
SGTC_1530 rhein 70.4 µM 0.434976045508031 0.261167795027135 no 894 0.331789907518247 1577 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2186 6124449 200 µM 0.434307755502642 0.261412309555092 no 895 0.332032486384702 1619 3834182 YLR033W RSC58
SGTC_411 enrofloxacin 100 µM 0.433402333248603 0.261743773672213 no 896 0.332361252878419 1738 71188 A bacterial gyrase inhibitor.
SGTC_844 0330-0132 15.3 µM 0.432929899885815 0.261916811370365 no 897 0.332532848680407 1639 2828079
SGTC_3175 9106517 49.47 µM 0.43203574646116 0.262244472555318 no 898 0.332857716412053 1543 41468073
SGTC_3300 9124615 50.48 µM 0.428614428812854 0.263500145332296 no 899 0.33410192167493 1664 24824903
SGTC_1773 st048542 73.5835 µM 0.427724105845837 0.26382740910548 no 900 0.334425998713297 1501 3237138
SGTC_1134 3477-0009 42.5 µM 0.427462743589786 0.263923519641839 no 901 0.334521157867312 1770 3973534
SGTC_278 4092-0821 23.9 µM 0.427019845622473 0.264086426898251 no 902 0.334682436469786 1624 877900
SGTC_1421 4029-0249 71.4 µM 0.425866319382844 0.264510958631669 no 903 0.335102629161273 1701 2894095
SGTC_1743 st037606 46.3785 µM 0.425679388106266 0.264579787545891 no 904 0.335170741695232 1591 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1893 st059353 36.1 µM 0.423856115717159 0.26525160191903 no 905 0.335835375163596 1552 3112488
SGTC_6 0844-0013 19.835 µM 0.423573165261443 0.265355937195039 no 906 0.335938564573435 1659 1584900
SGTC_3309 9129340 25.759 µM 0.423545619757295 0.265366095448884 no 907 0.335948610824342 1649 17158987
SGTC_788 1182-0090 188 µM 0.422776175531488 0.265649931462306 no 908 0.336229285803886 1750 5715185
SGTC_2067 5224629 34.075 µM 0.422739671580536 0.265663401026445 no 909 0.336242603848263 1558 2835000
SGTC_3172 9105863 49.47 µM 0.42244715894233 0.265771347539324 no 910 0.336349331122297 1633 2348785
SGTC_1644 st010134 20.9 µM 0.421997216849652 0.265937433945025 no 911 0.336513524450398 1636 3818134
SGTC_907 3448-6986 75.5 µM 0.421899387277366 0.265973552577333 no 912 0.33654922864537 1681 590582
SGTC_1296 1068-0102 11.9 µM 0.42136483239986 0.266170953866748 no 913 0.336744347529483 1640 767053
SGTC_3352 9151559 45.5865 µM 0.420379246468717 0.266535106990697 no 914 0.337104213304579 1548 17159339
SGTC_1246 0422-0085 105 µM 0.420105500823522 0.266636294899374 no 915 0.337204192189306 1694 264295
SGTC_107 0358-0022 2.6945 µM 0.418864754481518 0.267095170335163 no 916 0.337657488443287 1682 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2051 5263410 176 µM 0.418683244917383 0.267162332926931 no 917 0.337723821209172 1615 227584
SGTC_3081 9117243 49.47 µM 0.416615073480495 0.267928204006907 no 918 0.33847999107532 1719 45595589
SGTC_2880 9042983 58.44 µM 0.41409253980234 0.268863825734418 no 919 0.339403168053348 1599 6464714
SGTC_423 5-fluorouracil 457 µM 0.413605465447978 0.269044673116431 no 920 0.339581534968525 1506 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1992 st073643 23.3 µM 0.412330526586014 0.269518338079471 no 921 0.340048588384763 1609 3161292
SGTC_2914 7968218 45.32 µM 0.410431258122621 0.270224727959172 no 922 0.340744810189396 1693 2977111
SGTC_1214 0358-0031 63.7 µM 0.409987392252709 0.270389947181306 no 923 0.340907598074785 1795 4301366
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.409818650215901 0.270452770903709 no 924 0.340969492020151 1680 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2994 9053520 71.4286 µM 0.408667719766061 0.270881464002062 no 925 0.341391763071514 1719 4647384
SGTC_520 3584-0023 682 µM 0.407659332849221 0.27125734167397 no 926 0.341761898854897 1586 1340790
SGTC_235 0330-0087 5 mM 0.407636996109401 0.271265670668175 no 927 0.34177009944243 1599 46494818 YHR062C RPP1
SGTC_96 0929-0093 37.281 µM 0.407494516602184 0.271318801877319 no 928 0.341822410340402 1581 6991579
SGTC_2677 mitomycin C 100 µM 0.405995283319519 0.271878186501933 no 929 0.342373033025934 1617 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1300 1094-0077 113 µM 0.40561477290829 0.272020251425219 no 930 0.34251283628477 1588 5532636
SGTC_1252 0493-0875 34.8 µM 0.404896112663673 0.272288666459548 no 931 0.342776937961761 1584 3960963
SGTC_43 0570-0105 72.5 µM 0.404810849789678 0.272320520331784 no 932 0.342808276463066 1649 1114046 YDL195W SEC31
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.404666686448255 0.272374383396731 no 933 0.342861266382867 1600 3256 An antibiotic and ribosome inhibitor.
SGTC_2343 7990716 14.84 µM 0.403060359438257 0.272974905491976 no 934 0.343451910695115 1661 6456862
SGTC_333 3486-0131 40.1 µM 0.402789665766954 0.273076168367092 no 935 0.343551482097497 1742 6744690
SGTC_1360 1598-0022 39.8 µM 0.401919800038075 0.273401699474435 no 936 0.343871525186526 1722 761525
SGTC_1446 4239-0190 62 µM 0.400653284308824 0.273876012770351 no 937 0.344337704734074 1612 1340085
SGTC_1351 1496-0003 46.5 µM 0.3992033393496 0.274419519772455 no 938 0.344871691438966 1694 3891978
SGTC_999 SEC7.066 22.7 µM 0.398609675142132 0.274642206309793 no 939 0.345090415754996 1679 740511 YDR170C SEC7
SGTC_2213 7173844 200 µM 0.398570981172904 0.274656723712524 no 940 0.345104673611607 1608 892728
SGTC_3335 9143315 29.6265 µM 0.398201013315246 0.274795549265252 no 941 0.345241009538555 1595 4899691
SGTC_2034 5197015 53.07 µM 0.396737766265109 0.275344952116498 no 942 0.345780423711619 1726 780676
SGTC_751 0833-0568 350 µM 0.394584489710688 0.276154420907351 no 943 0.34657478102716 1669 6954252
SGTC_2488 5268135 45.7 µM 0.394511339894515 0.27618194019558 no 944 0.346601778332331 1696 1270356 YLR208W SEC13
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.393373036395553 0.276610348417997 no 945 0.347021990805375 1717 688662
SGTC_1554 st069299 38.7 µM 0.392153430695619 0.277069716415002 no 946 0.347472425373755 1670 24207999
SGTC_820 1582-0060 59.9 µM 0.391186527099535 0.277434168575019 no 947 0.347829683135986 1597 3848840
SGTC_2380 9035439 200 µM 0.390551850944766 0.277673522542348 no 948 0.348064260857365 1726 6462575
SGTC_261 5-fluorouridine 15.376 µM 0.389462285491715 0.278084662941621 no 949 0.348467102241628 1716 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_346 4513-0042 7.16 µM 0.389374860374744 0.278117665103442 no 950 0.348499433052578 1608 2827372
SGTC_66 0109-0187 42.4 µM 0.388580391190468 0.278417657300405 no 951 0.34879328728806 1563 759417
SGTC_2307 7538926 6.34 µM 0.38799338517974 0.278639412484963 no 952 0.349010464390369 1631 96582
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.387758441302956 0.27872819209756 no 953 0.349097401437995 1755 16725076
SGTC_1020 4335-0961 93.3 µM 0.387207228265993 0.278936536217699 no 954 0.349301399675432 1570 669075
SGTC_2357 9067248 200 µM 0.38688724468982 0.279057516390935 no 955 0.349419842263175 1682 9150235
SGTC_983 1491-0821 12.2 µM 0.383841652813692 0.280210276676602 no 956 0.350547906971758 1761 46495113
SGTC_3036 9090181 49.47 µM 0.383456307278729 0.280356294688763 no 957 0.350690730331016 1670 25236586
SGTC_2120 5538279 151.968 µM 0.383218054290257 0.280446593722514 no 958 0.350779046292327 1664 2058197
SGTC_1140 3229-1848 2.98 µM 0.382371334705925 0.280767618417703 no 959 0.351092974751463 1740 2849525
SGTC_613 3914-0030 117 µM 0.381968733998214 0.280920322491419 no 960 0.351242278045051 1636 1145395
SGTC_695 3505-6186 243 µM 0.381881520686661 0.280953407275208 no 961 0.351274623872779 1700 1819379
SGTC_880 0833-0487 87.2 µM 0.38085452058382 0.281343146228221 no 962 0.351655600472705 1623 76075
SGTC_2439 5492030 7.2 µM 0.380017173274395 0.28166110634651 no 963 0.351966333669222 1753 5722370
SGTC_1716 st033144 30.6155 µM 0.378761473119264 0.28213824919728 no 964 0.352432499704624 1781 674617
SGTC_1619 st003326 88.7 µM 0.37818112061716 0.282358903827167 no 965 0.352648024696558 1743 2849032
SGTC_1959 st077091 55.8 µM 0.376881817288387 0.282853210039302 no 966 0.353130717242592 1645 821356 YKL052C ASK1
SGTC_2354 9060492 162 µM 0.376741304477579 0.282906691545731 no 967 0.353182932077838 1765 6471895
SGTC_2993 9054257 71.4286 µM 0.374558620315094 0.283738080285323 no 968 0.353994376189984 1625 6470217 YGL055W OLE1
SGTC_1165 k072-0275 30.3 µM 0.374415862344965 0.283792497818835 no 969 0.354047471669805 1694 6153523 YGL055W OLE1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.373999352296124 0.283951294735086 no 970 0.35420239903293 1796 6728940
SGTC_1936 st074407 74.3 µM 0.372361198568143 0.284576262663826 no 971 0.354811969601073 1620 809813
SGTC_951 1171-0579 82.7 µM 0.372124857847826 0.284666482612475 no 972 0.354899944674934 1592 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3338 9144300 39.5675 µM 0.372021202671576 0.284706055914238 no 973 0.354938531545345 1718 4901274
SGTC_1901 st060216 58.6 µM 0.370753664664274 0.285190186743278 no 974 0.355410507866458 1631 688792
SGTC_2438 5259590 200 µM 0.370600545730975 0.285248696426601 no 975 0.355467537765166 1803 1201127
SGTC_3096 9117468 49.47 µM 0.369797854494724 0.285555513697299 no 976 0.355766556983588 1690 41316311
SGTC_149 3970-0822 46.1 µM 0.36962139001688 0.285622985781933 no 977 0.355832305589024 1674 3114250 YBL034C STU1
SGTC_143 4032-1194 15.74 µM 0.369062409479721 0.285836764877246 no 978 0.356040603515018 1667 1806963
SGTC_3121 9125696 49.47 µM 0.367664228262565 0.286371824672924 no 979 0.356561808374812 1731 1235365
SGTC_724 3910-0327 137 µM 0.366391972078471 0.286859107870905 no 980 0.35703630462791 1628 2885483
SGTC_1327 1436-0082 2.18 µM 0.366294008759565 0.286896644807523 no 981 0.357072849869361 1695 15992205
SGTC_1398 3558-0053 112 µM 0.364246715907412 0.287681644992317 no 982 0.357836892614055 1670 4532369
SGTC_3019 9081971 49.47 µM 0.364138304439859 0.287723241837392 no 983 0.3578773673205 1784 16451803
SGTC_2161 5662504 8.5105 µM 0.361405171108627 0.288772866832173 no 984 0.358898291444523 1654 2859334
SGTC_743 1275-0778 158 µM 0.360383971674605 0.289165507550607 no 985 0.359280005626683 1792 2849257 YMR203W TOM40
SGTC_2002 4023503 131 µM 0.360181644129288 0.289243330201306 no 986 0.359355650336654 1870 4736863 YCR052W RSC6
SGTC_2910 7948405 25.97 µM 0.358117339846496 0.290037899973802 no 987 0.360127751570161 1812 2971328
SGTC_1991 st073000 8.92 µM 0.357990458290751 0.290086771215282 no 988 0.360175227089139 1761 4301969 YIL048W NEO1
SGTC_581 0958-0271 211 µM 0.357810724747826 0.290156006175363 no 989 0.360242482030009 1637 4591145
SGTC_2732 terfenadine 20 µM 0.357773897625348 0.290170193266376 no 990 0.360256262996431 1718 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3168 9103419 49.47 µM 0.356592849474346 0.29062534642927 no 991 0.360698315659267 1742 16649256
SGTC_402 epigallocatechin gallate 10 µM 0.356579621531183 0.290630446114068 no 992 0.360703267780881 1660 65064 An antioxidant.
SGTC_2008 4012253 172 µM 0.356515193480168 0.290655285249283 no 993 0.360727387929965 1672 603940
SGTC_3288 9119690 36.221 µM 0.353588673419998 0.291784600621153 no 994 0.361823581997304 1644 17595618 YKL019W RAM2
SGTC_1857 st056007 79.3 µM 0.353576671312678 0.291789236323255 no 995 0.361828079999573 1730 619834
SGTC_1343 1487-0095 224 µM 0.352968101523254 0.292024335702565 no 996 0.362056177315141 1813 4560101 YGL055W OLE1
SGTC_2563 tomatine 8.54 µM 0.352927902092624 0.292039868432987 no 997 0.36207124614184 1947 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_264 promethazine 12.5 mM 0.352596673765086 0.292167866980998 no 998 0.362195415794329 1703 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1746 st038117 42 µM 0.351731254646471 0.292502419221199 no 999 0.362519909334977 1690 2898218
SGTC_835 0312-0010 67.2 µM 0.347826853243195 0.294013985067348 no 1000 0.363985110720825 1697 1626196
SGTC_2212 7123476 200 µM 0.346900317540424 0.294373217337083 no 1001 0.364333104041176 1764 1085715
SGTC_2069 5228469 200 µM 0.346288588103696 0.294610505347298 no 1002 0.364562922039405 1674 2835210
SGTC_2124 5246320 200 µM 0.346131935081393 0.294671284772688 no 1003 0.364621782172489 1728 579342
SGTC_3161 9100388 49.47 µM 0.345957400498464 0.294739008831892 no 1004 0.364687364805133 1769 25236368
SGTC_1462 k081-0014 26.5 µM 0.345683019991819 0.29484549027276 no 1005 0.364790473271795 1619 3270634
SGTC_680 0417-1641 114 µM 0.345199458407484 0.295033193745385 no 1006 0.364972212947899 1689 2835990
SGTC_2830 7992007 71.43 µM 0.344898313257561 0.295150116674441 no 1007 0.365085409360089 1651 1952075
SGTC_669 0108-0021 26.2 µM 0.343938763989395 0.295522814495426 no 1008 0.365446169400744 1947 17201
SGTC_1337 1486-1011 40.3 µM 0.343875047405366 0.295547570267089 no 1009 0.365470129031475 1688 X1337
SGTC_2720 fluspirilene 36.88 µM 0.343703268115606 0.295614316336462 no 1010 0.365534726577766 1767 3396 An atypical antipsychotic.
SGTC_732 3970-1727 52.7 µM 0.342418790028216 0.296113628945188 no 1011 0.366017874917672 1855 1275699
SGTC_2524 avocatin b 10.57 µM 0.342161569908839 0.296213664099922 no 1012 0.366114652211092 1817 6710748
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.341315147576031 0.296542954533911 no 1013 0.366433172869321 1592 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2024 5144227 134 µM 0.341271823088148 0.296559813916288 no 1014 0.366449478962626 1784 3475211
SGTC_2313 7726885 200 µM 0.341040656778454 0.296649777882039 no 1015 0.366536487398817 1718 726423
SGTC_2680 butyl paraben 22.24 µM 0.340520114284816 0.296852405343787 no 1016 0.366732438931416 1732 7184 An antifungal and steroid mimetic.
SGTC_2318 6029776 164 µM 0.339917708633178 0.29708697806576 no 1017 0.366959250155124 1773 818325
SGTC_2130 NSC 7 2.4545 µM 0.339629698920187 0.297199157058077 no 1018 0.367067704856187 1825 21448
SGTC_2939 9044578 71.43 µM 0.339377919872103 0.297297240164329 no 1019 0.367162525007735 1673 2653634
SGTC_1916 st067606 49.2 µM 0.338827549511335 0.297511694059682 no 1020 0.36736982304641 1805 19590279
SGTC_3348 9149464 3.537 µM 0.337874341845132 0.297883282032376 no 1021 0.367728941949431 1700 1951442
SGTC_1770 st043884 66.3 µM 0.336992564843084 0.298227212565236 no 1022 0.368061252512387 1709 670149
SGTC_1190 1486-1332 13 µM 0.336177869537228 0.298545139012189 no 1023 0.368368370139236 1673 4150046
SGTC_2785 7756463 72.73 µM 0.334615493777144 0.299155270959986 no 1024 0.368957577851802 1660 2201551
SGTC_367 0335-0881 7.1 µM 0.333231648794588 0.299696156014477 no 1025 0.369479714871484 1810 23828853
SGTC_3075 9116269 49.47 µM 0.332895779210722 0.29982749965953 no 1026 0.369606477806058 1747 17015205 YNL244C SUI1
SGTC_139 0099-0334 718.624 µM 0.332298489221305 0.300061137548271 no 1027 0.369831940287707 1805 97690
SGTC_163 TUB2.036 7.546 µM 0.331462425124429 0.300388313339474 no 1028 0.370147609352971 1782 15992207 YJR013W GPI14
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.331406343813179 0.300410265327868 no 1029 0.370168786861823 1811 17037758
SGTC_1189 1431-2119 7.28 µM 0.331299405989847 0.300452126162513 no 1030 0.370209169973821 1736 3107275
SGTC_337 1315-0038 354 µM 0.330392935606704 0.30080706997442 no 1031 0.370551539349454 1720 1626437
SGTC_2189 6047310 154.431 µM 0.330083394885956 0.300928319192744 no 1032 0.370668474848582 1734 711535
SGTC_1931 st074438 57.1 µM 0.329688631993622 0.301082982485251 no 1033 0.370817622144697 1700 2787313
SGTC_871 0574-0004 149 µM 0.329004417515751 0.301351134200873 no 1034 0.371076174527632 1737 9551173
SGTC_1021 4476-0760 85.3 µM 0.328084407665948 0.301711866289644 no 1035 0.371423921490154 1662 746768
SGTC_2746 daunorubicin 9.88 µM 0.327105321695146 0.302095974993194 no 1036 0.371794113452054 1847 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_115 0527-0192 112.043 µM 0.326715048982649 0.302249145448931 no 1037 0.37194170845911 1739 4233931
SGTC_2621 lithochol-11-enic acid 100 µM 0.324782343222139 0.303008188147349 no 1038 0.372672904400641 1884 6708711
SGTC_1938 st074717 56.4 µM 0.323977562517757 0.303324505660695 no 1039 0.372977510690289 1705 17250979
SGTC_1106 tegaserod maleate 11.7 µM 0.323653101539229 0.303452076158338 no 1040 0.373100340355029 1770 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2269 7935389 174.42 µM 0.323031533058013 0.303696529316406 no 1041 0.37333568062335 1675 97605
SGTC_1415 3966-0071 78.1 µM 0.32178822562871 0.304185766204239 no 1042 0.373806567427078 1773 2893185
SGTC_2329 6138490 200 µM 0.320569498913276 0.304665671142783 no 1043 0.374268327483305 1758 720019
SGTC_2959 9079155 11 µM 0.3204623693516 0.304707872253236 no 1044 0.374308926148662 1772 16189457
SGTC_3231 9132313 49.47 µM 0.318608267114476 0.305438662500293 no 1045 0.375011791835951 1770 4905967
SGTC_2038 4100038 30.985 µM 0.317429958351725 0.305903493750775 no 1046 0.375458689118043 1771 3596803
SGTC_2533 agelasine 13.65 µM 0.317061219240753 0.306049022011915 no 1047 0.3755985752093 1921 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2296 7971656 126.45 µM 0.316950022031574 0.306092913619986 no 1048 0.375640762561649 1716 666570
SGTC_766 1391-0721 126 µM 0.316782342573489 0.306159105086989 no 1049 0.375704381649343 1846 1020919 YIL115C NUP159
SGTC_922 1866-0035 480 µM 0.315785354365448 0.306552796808974 no 1050 0.376082717628871 1772 3156169
SGTC_696 1560-0013 611 µM 0.31514781016672 0.306804668023557 no 1051 0.37632471466417 1815 1650269
SGTC_1002 4049-0206 172 µM 0.314229275639656 0.307167709001202 no 1052 0.376673454605362 1717 4662749
SGTC_2947 9072639 7.68 µM 0.314200382603778 0.307179131734826 no 1053 0.376684426056856 1687 16488146
SGTC_2695 st077686 51.995 µM 0.312807695562175 0.307729946077047 no 1054 0.37721338419044 1706 2876092
SGTC_84 0443-0269 128.823 µM 0.312658867123555 0.30778883409931 no 1055 0.377269924545793 1827 6150058
SGTC_849 0386-0493 241 µM 0.311761436230131 0.308144031963038 no 1056 0.377610916869371 1752 726119
SGTC_689 0833-0039 98 µM 0.311320423435046 0.308318648125467 no 1057 0.377778521274757 1864 5374726
SGTC_373 0844-0104 25.9 µM 0.310843130294776 0.308507678135642 no 1058 0.377959939748849 1872 5375804
SGTC_3054 9094397 49.47 µM 0.310007706594776 0.308838666481741 no 1059 0.378277547931042 1709 2598354
SGTC_1177 0983-0204 23.6 µM 0.30994909942021 0.308861892019707 no 1060 0.378299832072575 1909 766818
SGTC_282 k297-0036 65.7 µM 0.306573275464573 0.310200990695724 no 1061 0.379584098891738 1806 5061378
SGTC_1960 st011366 51.8 µM 0.306032656410725 0.310415674362019 no 1062 0.379789890815862 1756 3972846
SGTC_1383 3049-0032 20.7 µM 0.305927802181057 0.310457320203652 no 1063 0.379829808546925 1894 712864
SGTC_2800 7887935 81.82 µM 0.305368265154458 0.310679597328751 no 1064 0.380042844468697 1803 2961002
SGTC_3229 9132204 49.47 µM 0.304733762383078 0.310931738372213 no 1065 0.380284466595433 1820 17682924
SGTC_1752 st044819 83.042 µM 0.304141476847522 0.311167183106159 no 1066 0.380510054333046 1726 441209 YML126C ERG13
SGTC_2006 4011487 200 µM 0.303299699573343 0.311501938506031 no 1067 0.38083073755918 1871 45595294
SGTC_965 1291-5240 308 µM 0.30309966808515 0.31158150934646 no 1068 0.380906953545603 1864 2834598
SGTC_1166 k206-0078 225 µM 0.302924142030999 0.311651339380818 no 1069 0.380973836279589 1739 5404595
SGTC_939 1165-0479 45.3 µM 0.300525845478779 0.312606138304576 no 1070 0.381888042579866 1910 1377347
SGTC_357 1325-0123 420 µM 0.299903570073014 0.312854081743631 no 1071 0.382125355542157 1910 1098503
SGTC_291 SEC14.278 35.5 µM 0.298990558050699 0.313218021420456 no 1072 0.382473624904999 1874 1068044
SGTC_1411 3909-8223 150 µM 0.298784583948359 0.313300150823626 no 1073 0.382552207089954 1887 X1411
SGTC_537 1334-0398 209 µM 0.297645287503675 0.313754597139131 no 1074 0.382986952910908 1923 5846986
SGTC_2336 9001819 198.65 µM 0.297079838809422 0.31398025020269 no 1075 0.383202778100541 1861 2989602
SGTC_3241 9133421 49.47 µM 0.296864149773621 0.314066343353947 no 1076 0.383285113653257 1805 17018221
SGTC_8 0354-0001 70 µM 0.294052651307589 0.315189488630901 no 1077 0.38435883545888 1797 4993152
SGTC_2465 5809242 33.21 µM 0.293121696349098 0.315561766601272 no 1078 0.384714566739418 1843 2731748
SGTC_3128 9127691 49.47 µM 0.288901496694099 0.317251719001075 no 1079 0.386328379173806 1811 41316314
SGTC_1222 0366-0074 1.18 µM 0.288745993280916 0.31731406249889 no 1080 0.386387881747629 1921 286520
SGTC_2619 obliquin 87.91 µM 0.286778440124568 0.318103329377289 no 1081 0.387140986076605 1881 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2031 5180455 200 µM 0.285889736782093 0.318460096285257 no 1082 0.387481287346537 1791 29949
SGTC_465 cgp-37157 41 µM 0.285635673222429 0.318562120198157 no 1083 0.387578588979629 1890 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1986 st071812 45 µM 0.285212858174654 0.318731939883888 no 1084 0.387740534955666 1808 11838594
SGTC_2436 5633522 8.09 µM 0.284693420459762 0.318940619271763 no 1085 0.38793951593117 1939 5724242
SGTC_3074 9116018 49.47 µM 0.283586775133709 0.319385395360134 no 1086 0.388363536562002 1810 17027303
SGTC_211 3455-0679 143.504 µM 0.28205031621205 0.320003350517507 no 1087 0.388952464516374 1806 748649
SGTC_668 1682-0499 62.6 µM 0.280327200418019 0.320696972536433 no 1088 0.38961324205677 1812 682214
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.279373999972574 0.321080942597836 no 1089 0.389978911024811 1803 689007
SGTC_3147 9097027 49.47 µM 0.279253495195644 0.321129498202145 no 1090 0.390025146287849 1852 25236841
SGTC_755 1995-0008 37.3 µM 0.272544075716124 0.323837764138827 no 1091 0.392601852948752 1921 689533
SGTC_551 k048-0028 34.9 µM 0.271113559344067 0.324416408542233 no 1092 0.393151846576488 1915 6836383
SGTC_1040 k898-0338 155 µM 0.270963098279308 0.324477294778342 no 1093 0.393209707075436 2004 20969351
SGTC_973 1325-0077 65.9 µM 0.270494634535933 0.324666895418235 no 1094 0.393389872077424 1928 2835149
SGTC_19 0279-0214 38.434 µM 0.269305774996022 0.325148264692877 no 1095 0.393847194246959 1853 3566274 YBR002C RER2
SGTC_2165 5727197 32.143 µM 0.269101125875335 0.325231156606891 no 1096 0.39392593202944 1863 1361712
SGTC_17 0960-0276 49.807 µM 0.267552337186735 0.325858764449875 no 1097 0.394521961533789 1856 6821114
SGTC_671 0560-0003 407 µM 0.267343514952227 0.325943422247318 no 1098 0.394602342756937 1892 3238678
SGTC_661 1304-0007 33.6 µM 0.267071386039705 0.326053758421555 no 1099 0.39470709913551 1819 3117130
SGTC_556 4058-0063 51.5 µM 0.266566650270337 0.326258446652176 no 1100 0.394901417977636 1839 6615692
SGTC_562 3772-2733 112 µM 0.266420947691958 0.32631754394675 no 1101 0.394957517057072 1939 2876874 YIL048W NEO1
SGTC_2148 5546263 113.568 µM 0.266386046655298 0.326331700533409 no 1102 0.394970955138683 1839 792097
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.265593664866299 0.326653174362316 no 1103 0.395276082562778 1785 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_839 0122-0028 230 µM 0.265345090716424 0.326754048859839 no 1104 0.395371815811052 1870 759448
SGTC_2223 6903751 107.57 µM 0.264414152190519 0.327131947835769 no 1105 0.395730403801752 1899 5598863
SGTC_275 trichlorophene 5.69 µM 0.264402851587736 0.327136536216984 no 1106 0.395734757221158 1851 62616
SGTC_339 3091-4833 71.4 µM 0.264284043106386 0.327184777579176 no 1107 0.395780527526845 1878 3240077
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.264083951026727 0.327266030109656 no 1108 0.395857615134125 1941 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_631 k072-0230 41.5 µM 0.263952620055795 0.327319364874824 no 1109 0.3959082140055 1890 5773147
SGTC_2222 6885208 172.143 µM 0.263943078500346 0.327323239929262 no 1110 0.395911890220721 1869 609514
SGTC_2417 cerulenin 830 nM 0.263668474241391 0.327434771275686 no 1111 0.39601769500336 1828 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1952 st077036 64.1 µM 0.26320718754064 0.327622158926207 no 1112 0.396195445608547 1956 2937007
SGTC_2996 9066192 71.4286 µM 0.263033516987401 0.3276927200518 no 1113 0.39626237280698 1747 6472854
SGTC_2560 caryophyllene 100 µM 0.26168306274412 0.328241609921875 no 1114 0.396782899802472 1813 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2282 7944268 200 µM 0.26153264077164 0.328302771667468 no 1115 0.396840890732896 1908 2970414
SGTC_1357 1503-1303 39.5 µM 0.261205268018816 0.328435897708147 no 1116 0.396967107908111 1833 292895
SGTC_1796 st049173 110.4 µM 0.261157017965688 0.328455520421441 no 1117 0.396985711424218 1955 94134
SGTC_784 4579-0127 173 µM 0.260940954946271 0.328543396442286 no 1118 0.397069020566965 1980 1948547
SGTC_3015 9080845 49.47 µM 0.260652867187328 0.328660580741003 no 1119 0.397180108169428 1944 5296973
SGTC_366 0181-0206 4.31 µM 0.258520219343495 0.329528592771509 no 1120 0.398002723184796 1998 274874
SGTC_2851 9015922 71.43 µM 0.257322739810576 0.330016383950628 no 1121 0.398464819758782 1927 2996893
SGTC_901 1112-0062 60.1 µM 0.254763449131558 0.331059875031391 no 1122 0.399452903645007 1853 1908457
SGTC_2570 licareol 100 µM 0.252819103866197 0.331853515087377 no 1123 0.400204002210111 1821 443158
SGTC_1102 cgs 12066b 26.1 µM 0.252636487528186 0.331928094008112 no 1124 0.400274565725703 1877 6438352 A 5-HT1B full agonist.
SGTC_1459 k035-0031 35.7 µM 0.251777184252432 0.332279115332357 no 1125 0.400606646823773 1768 3877128 YMR208W ERG12
SGTC_2725 haloperidol 53.21 µM 0.251553944155247 0.332370331954033 no 1126 0.400692930596577 1905 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_10 0279-0212 42.575 µM 0.251301871295975 0.332473341670995 no 1127 0.400790364246987 1866 39851 YBR002C RER2
SGTC_592 k241-0073 46.5 µM 0.25004466517524 0.332987288463967 no 1128 0.401276403814309 1975 4230158
SGTC_1937 st074714 47.2 µM 0.249067120045219 0.33338712662017 no 1129 0.401654431266302 1732 17250970
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.249060092812652 0.33339000160399 no 1130 0.401657149108062 1893 97141
SGTC_2063 5246145 200 µM 0.247753334647675 0.333924792931474 no 1131 0.402162631456181 1919 711240
SGTC_2117 5521686 200 µM 0.246753144266713 0.334334349335852 no 1132 0.402549637375099 1810 803312
SGTC_3162 9099653 49.47 µM 0.245476062129063 0.334857573675885 no 1133 0.403043920449787 1962 25237511
SGTC_629 3448-6466 76.7 µM 0.245420160331443 0.334880484142548 no 1134 0.403065560280184 1882 573744
SGTC_2118 5526350 200 µM 0.244014156877598 0.335456914308392 no 1135 0.403609927836868 1912 743594
SGTC_2035 5154463 94.595 µM 0.240347237959001 0.336962090117459 no 1136 0.40503053871083 1979 2769623
SGTC_1263 0774-1208 64.8 µM 0.239893205200281 0.337148641257475 no 1137 0.405206524271408 2010 906585
SGTC_2784 7567673 72.73 µM 0.23869884324195 0.33763956702148 no 1138 0.405669556894965 1887 3471247
SGTC_2915 7971052 15.16 µM 0.238633376245309 0.337666484312214 no 1139 0.405694941093062 1973 5741558
SGTC_2587 piperic acid 92.2 µM 0.237951935537988 0.337946713515242 no 1140 0.40595918669942 1844 5370536
SGTC_443 clozapine 122 µM 0.237420899678211 0.338165153948103 no 1141 0.406165138793894 2023 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2337 9009472 200 µM 0.235929607981466 0.338778884691881 no 1142 0.406743646417855 1987 5742383
SGTC_1414 3917-0015 5.4 µM 0.234973517235955 0.339172582620157 no 1143 0.407114643998822 1962 6618702
SGTC_1233 0325-0408 14.2 µM 0.23312853844073 0.339932802093851 no 1144 0.407830797444942 1961 12874
SGTC_2020 4017018 200 µM 0.232520053795357 0.340183669852945 no 1145 0.408067056656022 1873 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1873 rapamycin 2 nM 0.232486225875225 0.340197618600165 no 1146 0.408080192164219 1868 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3290 9121031 71.43 µM 0.230260342306472 0.341115928642194 no 1147 0.408944737459425 1857 17014854
SGTC_985 1493-0307 8.71 µM 0.229667114211341 0.341360829888394 no 1148 0.409175225451481 2015 3278274
SGTC_2435 5706476 10.6 µM 0.229391476677887 0.341474643559684 no 1149 0.409282330094969 2021 5725375
SGTC_212 3807-4682 38.772 µM 0.22806578569654 0.3420222367353 no 1150 0.409797549120158 1991 3125501 YBL034C STU1
SGTC_39 0986-0283 58.349 µM 0.227918812086383 0.342082966508491 no 1151 0.409854678828621 2008 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_75 0159-0059 199.013 µM 0.227773530284491 0.342143001238311 no 1152 0.409911152799793 1980 5377270
SGTC_1970 st070122 35.8 µM 0.227185007156832 0.34238623717961 no 1153 0.410139942735106 1984 102928
SGTC_1606 st000094 49.2 µM 0.226460159179535 0.342685905885943 no 1154 0.410421771353583 2045 1242210
SGTC_1961 st076550 68.7 µM 0.22597885570152 0.342884942454862 no 1155 0.410608932843652 1912 1579337
SGTC_2521 angolensin 13.4 µM 0.22467554653853 0.343424127213319 no 1156 0.411115844654292 1927 821428 A flavenoid.
SGTC_2484 5809818 12.04 µM 0.222901195918704 0.344158696221317 no 1157 0.411806202797888 1892 2870548
SGTC_2448 5185112 27.17 µM 0.222460108406396 0.344341394857423 no 1158 0.411977862049923 1898 5718189
SGTC_1709 st033179 39.1045 µM 0.222319331483415 0.344399712368645 no 1159 0.412032652143488 1912 573381
SGTC_57 miconazole 162.5 nM 0.221312058361846 0.344817087916469 no 1160 0.412424730772659 1842 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_798 1287-0182 476 µM 0.220729728371832 0.345058469464407 no 1161 0.412651441214337 2036 1649755
SGTC_2267 7931562 200 µM 0.218180601139526 0.346115849025538 no 1162 0.413644199525803 1769 934880
SGTC_2181 6316240 54.2555 µM 0.217904958829286 0.346230257717852 no 1163 0.413751581699159 1859 12779990
SGTC_3020 9089140 49.47 µM 0.2171880102537 0.346527901643547 no 1164 0.414030914058878 1895 17217859
SGTC_2601 securinine 100 µM 0.216940176470527 0.346630812834086 no 1165 0.4141274834034 1887 442872 A GABA receptor antagonist.
SGTC_1259 0671-0132 43 µM 0.215212936002735 0.347348350947308 no 1166 0.414800652878197 1888 X1259
SGTC_519 k048-0011 62.8 µM 0.2148741179504 0.347489168593906 no 1167 0.414932732224124 1933 6836379
SGTC_342 k048-0088 23.3 µM 0.214844045931121 0.347501667974169 no 1168 0.414944455478252 1882 6820570
SGTC_2967 9089538 49.85 µM 0.214663030786425 0.347576910093301 no 1169 0.415015023890408 2065 728216
SGTC_2517 totarol 10 µM 0.213715978926124 0.347970666645804 no 1170 0.415384274921409 1864 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1713 st033146 12.748 µM 0.213258573230389 0.348160901355179 no 1171 0.415562642021013 2013 674619
SGTC_933 2914-0560 114 µM 0.213049505244826 0.348247865311966 no 1172 0.415644174677385 2081 463887
SGTC_2377 9073351 62.6 µM 0.212837201426475 0.348336183411957 no 1173 0.415726972965259 1858 7337946 YHR072W ERG7
SGTC_3228 9131799 49.47 µM 0.210616036061131 0.349260677492026 no 1174 0.416593449013125 1952 17015818
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.210146311519 0.349456301225338 no 1175 0.416776740513031 1926 5379071
SGTC_3313 9133968 57.047 µM 0.208749672044876 0.350038188447608 no 1176 0.417321830782451 1968 1494643
SGTC_1158 4092-0494 91.8 µM 0.208636521788351 0.350085346115083 no 1177 0.417365998833516 2010 1148199
SGTC_572 0960-0087 17.7 µM 0.204011154339842 0.352015033437703 no 1178 0.419172391159891 1907 6796365
SGTC_1075 aripiprazole 15.2 µM 0.201997476205167 0.352856328762322 no 1179 0.419959348605527 1921 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3299 9121982 43.1275 µM 0.201137183372016 0.35321597056717 no 1180 0.420295653972648 1920 17594604 YPL160W CDC60
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.198267176325255 0.35441671183062 no 1181 0.42141801569075 2006 16486 A toxic proline analog.
SGTC_2624 nerol 100 µM 0.198172896040778 0.354456181049055 no 1182 0.421454896375684 2003 637566 A natural product oil.
SGTC_2891 9063876 19.48 µM 0.197658288410522 0.354671642398893 no 1183 0.421656213398334 2111 6472478
SGTC_2704 st078022 71.1 µM 0.19752777297807 0.354726295372011 no 1184 0.421707274931562 2065 54697681
SGTC_91 0417-1751 58.384 µM 0.196766443117984 0.355045159691229 no 1185 0.422005156108689 2088 6795624
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.195906397519799 0.355405490817645 no 1186 0.422341714901079 2069 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2670 beta-carotene 100 µM 0.193869089828209 0.35625957185689 no 1187 0.423139193612587 2042 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1188 1403-0014 4.57 µM 0.193288536834 0.356503083838281 no 1188 0.423366501666317 1939 9614867
SGTC_2989 9073649 71.4286 µM 0.193196599935868 0.356541651985349 no 1189 0.42340250071718 2106 21367202
SGTC_1978 st071761 42 µM 0.193091642776066 0.356585684013128 no 1190 0.4234435987972 1909 5147680
SGTC_2978 9011784 42.97 µM 0.192478318837195 0.356843026213216 no 1191 0.423683774721336 2102 2994934
SGTC_89 0302-0250 142.109 µM 0.192284807464985 0.356924234424101 no 1192 0.423759559117358 2094 4203518 YLR208W SEC13
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.191811437834258 0.357122914158549 no 1193 0.423944955614738 2099 688664
SGTC_2717 st081029 62.2815 µM 0.191274794695111 0.357348197515638 no 1194 0.424155153710828 2089 5292846
SGTC_1317 1273-0028 910 nM 0.191188990721961 0.357384222727426 no 1195 0.424188764326532 1966 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3012 9080433 71.4286 µM 0.190408049096754 0.357712163226146 no 1196 0.42449469539438 2096 17688859
SGTC_3325 9138760 55.175 µM 0.19039318318912 0.357718406880463 no 1197 0.424500519501959 1919 43844959
SGTC_1242 0402-0103 60.1 µM 0.188397073457828 0.35855711451208 no 1198 0.425282696832607 1997 432868
SGTC_456 gingerol 170 µM 0.188116552348383 0.358675036177778 no 1199 0.425392642919716 2000 442793 A herb.
SGTC_478 N-arachidonylglycine 10 µM 0.187380093211469 0.358984682991875 no 1200 0.425681314742103 2067 5283389
SGTC_594 1487-1584 10.8 µM 0.18696854260213 0.359157761261588 no 1201 0.425842648677099 1913 5013332
SGTC_886 0866-0150 153 µM 0.18612643618324 0.359512000534409 no 1202 0.426172805528846 2108 271463
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.186041521512506 0.359547727324949 no 1203 0.426206100112192 1974 65057 A dermal irritant. YDR527W RBA50
SGTC_1871 st057448 67.3 µM 0.185398509847923 0.359818306304276 no 1204 0.426458238565115 2049 691747
SGTC_100 0086-0128 49.5915 µM 0.184604876649228 0.360152363628841 no 1205 0.426769480338434 1870 93297
SGTC_2545 solidagenone 89.61 µM 0.184568760959666 0.360167568044148 no 1206 0.426783645034902 2014 6708572 An anti ulcer agent
SGTC_1101 ebselen 5.29 µM 0.18437979018316 0.360247126829676 no 1207 0.426857761556251 2106 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2864 9034755 47.6 µM 0.18238188468089 0.361088636783887 no 1208 0.427641520655864 2123 4930451
SGTC_991 3996-0057 64.7 µM 0.182166880218036 0.361179235984985 no 1209 0.427725881914478 1992 715343
SGTC_767 0929-0023 86 µM 0.181311257589502 0.361539857831811 no 1210 0.428061635097985 2094 1204563
SGTC_2145 5634607 200 µM 0.179922981119426 0.362125240538536 no 1211 0.428606516644052 1951 308662
SGTC_974 1326-0144 138 µM 0.179227219657502 0.362418737796847 no 1212 0.428879645781259 1947 5411856
SGTC_1621 st003705 32.4 µM 0.178625122918366 0.362672789189824 no 1213 0.429116033254257 2109 24207032
SGTC_173 1273-0061 2.693 µM 0.177731783765759 0.363049840101037 no 1214 0.429466811397436 1919 2847414 YPL266W DIM1
SGTC_2984 9022109 38.96 µM 0.177281088021455 0.363240115293823 no 1215 0.429643802538077 2142 6459207
SGTC_1613 st002381 52.1 µM 0.176729318990444 0.363473107664946 no 1216 0.429860505065152 2131 551167
SGTC_3265 9137266 49.47 µM 0.176666186602259 0.363499769441472 no 1217 0.429885301114501 2144 17224265
SGTC_1407 3909-7909 12.3 µM 0.175746229131797 0.363888356555397 no 1218 0.430246657453455 1996 4411780
SGTC_1041 0206-0046 107 µM 0.172733760739555 0.365161791715241 no 1219 0.431430352710161 1995 50494
SGTC_190 3970-0790 3.722 µM 0.172567510888918 0.365232112563509 no 1220 0.431495695632205 2100 2832352
SGTC_1382 3002-2117 298 µM 0.172556306078566 0.365236852170005 no 1221 0.431500099643759 2101 1497314
SGTC_2236 dapsone 200 µM 0.171582224578974 0.365648964790075 no 1222 0.431882991460967 2113 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_199 4063-0024 41.6 µM 0.170976261971385 0.36590541263839 no 1223 0.432121215469391 2087 306215
SGTC_2133 5320837 200 µM 0.170148097123003 0.366255995014505 no 1224 0.432446834453463 2072 2841355
SGTC_1150 3909-7983 10.9 µM 0.169377015084336 0.366582513238784 no 1225 0.432750050796286 1973 23965914
SGTC_2862 9027634 71.43 µM 0.169275349700251 0.366625571123409 no 1226 0.432790032128905 1921 5012562
SGTC_3322 9139058 2.11 µM 0.168804706609315 0.366824922346975 no 1227 0.432975128058738 2061 4908926 YPR165W RHO1
SGTC_305 1682-2595 20.8 µM 0.168618868808423 0.366903647926919 no 1228 0.433048218959819 2025 226033
SGTC_2985 9022375 71.43 µM 0.168540853584356 0.366936698812114 no 1229 0.433078903405466 2014 4939335
SGTC_3 0833-0587 95.581 µM 0.168049278845171 0.367144975461946 no 1230 0.43327225569006 2027 5382644
SGTC_895 0964-0006 13.7 µM 0.167760126302804 0.367267505564951 no 1231 0.433385996225103 2104 6738897
SGTC_1066 ketoconazole 628 nM 0.167533474130295 0.367363560217567 no 1232 0.433475155582621 2073 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2265 7929201 200 µM 0.166302512618632 0.36788538359614 no 1233 0.433959444399071 2104 1265108
SGTC_2027 5150920 200 µM 0.166237008055676 0.367913158824342 no 1234 0.433985218198596 2071 786715
SGTC_619 1652-1634 108 µM 0.166104428688061 0.367969377207642 no 1235 0.434037384492686 1988 5400454
SGTC_948 3448-0295 75.3 µM 0.163150726122813 0.36922258382786 no 1236 0.435199880569556 2048 678569
SGTC_2783 7738165 71.43 µM 0.162288496857774 0.369588676213485 no 1237 0.435539336389114 1939 17201110
SGTC_1512 0259-0544 12.2 µM 0.162193499452316 0.369629018230723 no 1238 0.435576739353986 2004 18476
SGTC_1485 3909-9022 254 µM 0.162009890682931 0.369706994407863 no 1239 0.435649032565124 2110 714516
SGTC_3183 9108214 49.47 µM 0.161504402253583 0.369921696224914 no 1240 0.435848072188607 2104 4974831
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.160524316946976 0.370338094419738 no 1241 0.436234033923152 2037 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2440 5628896 157.78 µM 0.160466871235862 0.370362505474685 no 1242 0.436256658174423 2011 5522048
SGTC_2730 imipramine 71.33 µM 0.160400533508203 0.370390695764216 no 1243 0.43628278469102 2138 3696 A tricyclic antidepressant.
SGTC_14 0354-0009 295 µM 0.159779514878967 0.370654632046381 no 1244 0.436527380753044 2054 1713507
SGTC_1837 st055472 66.5 µM 0.158929981239721 0.371015787038909 no 1245 0.436862019642609 2073 676091
SGTC_142 0335-0849 62.6745 µM 0.158553313975247 0.371175952763793 no 1246 0.437010406715319 2077 3889043 YPR107C YTH1
SGTC_3118 9124250 49.47 µM 0.154281786428169 0.372993838703201 no 1247 0.438693778846825 2029 1504786
SGTC_697 0508-1955 564 µM 0.153490590315392 0.373330869675066 no 1248 0.439005705111611 2137 6243113
SGTC_2792 7535235 81.82 µM 0.152596300693032 0.373711932752638 no 1249 0.439358321226245 1982 1281891
SGTC_3273 9137859 49.47 µM 0.152479093884511 0.373761884556261 no 1250 0.439404539144334 2173 2377234
SGTC_3349 9149703 23.001 µM 0.152148835892385 0.373902647017866 no 1251 0.439534773535213 2128 4910494
SGTC_768 0384-0033 77.3 µM 0.150543478950471 0.374587121026834 no 1252 0.440167925166113 1952 3965305 YMR134W ERG29
SGTC_3115 9123671 49.47 µM 0.150415116290489 0.374641867950147 no 1253 0.44021855793613 2170 3286988
SGTC_1727 st034309 9.9045 µM 0.14929553412269 0.375119478939332 no 1254 0.4406602195179 2157 870305
SGTC_3077 9117319 49.47 µM 0.149011923085464 0.375240497142446 no 1255 0.44077211237253 2157 17154678
SGTC_2126 5251174 33.877 µM 0.148658035093913 0.375391520083619 no 1256 0.440911738173118 2145 790722
SGTC_976 1348-1067 47.6 µM 0.145140682856571 0.376893597308693 no 1257 0.44229989903883 2104 5310671 YGL099W LSG1
SGTC_1888 azatryptophan 97.5 µM 0.144629982604992 0.37711184628852 no 1258 0.442501511713097 2044 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_41 0478-0632 82.643 µM 0.142808004972667 0.377890792274066 no 1259 0.443220907415982 2190 3750424
SGTC_2050 5263056 171 µM 0.142793909147812 0.377896820570705 no 1260 0.443226473791093 2153 763468 YGL055W OLE1
SGTC_2700 st077718 96.8 µM 0.142143880602596 0.378174847571037 no 1261 0.443483179168067 2008 904970
SGTC_297 0986-0032 24 µM 0.142039996735157 0.378219286117259 no 1262 0.443524206563416 2054 2847425
SGTC_1865 st057639 52.2 µM 0.141585080028352 0.37841390543557 no 1263 0.443703876305698 2173 688818
SGTC_2456 5770359 74.46 µM 0.141583018727809 0.378414787357147 no 1264 0.443704690444475 2128 3118787
SGTC_3274 9138298 49.47 µM 0.141111078789979 0.37861672218135 no 1265 0.443891095810725 2179 17015756
SGTC_3184 9108758 49.47 µM 0.140640230029693 0.378818223142716 no 1266 0.444077082558335 2124 902885
SGTC_1291 0993-0025 5.79 µM 0.140554813172392 0.378854781042452 no 1267 0.444110823807799 2132 4353356
SGTC_1429 4049-0205 9.46 µM 0.140388258084983 0.37892606873221 no 1268 0.444176617334133 2152 22774478
SGTC_1341 1486-1360 280 µM 0.140263402693347 0.378979511124462 no 1269 0.444225939421361 2010 3976547
SGTC_2459 5811157 9.22 µM 0.1398572102671 0.379153391423836 no 1270 0.444386405090288 2180 2870684 YBR192W RIM2
SGTC_1732 st034308 51.822 µM 0.139810435934881 0.379173415856539 no 1271 0.444404883801299 1934 830119
SGTC_1975 st070967 30.8 µM 0.139774707585671 0.379188711641778 no 1272 0.444418998757439 2188 261391
SGTC_309 k408-0051 1.48 µM 0.139143377378914 0.37945902374583 no 1273 0.444668425703504 2076 3640463
SGTC_2487 5918373 44.05 µM 0.138627105023017 0.379680116166919 no 1274 0.44487241170034 2202 2876279
SGTC_3099 9120367 49.47 µM 0.136458515745977 0.38060923834487 no 1275 0.445729408680269 2151 24824940
SGTC_2762 leflunomide 42.06 µM 0.136115696269211 0.380756180996983 no 1276 0.44586490959298 2046 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_756 0508-1999 28.3 µM 0.135308222771794 0.381102356162494 no 1277 0.446184092018503 1962 6753853
SGTC_343 4130-2827 29.8 µM 0.13476558996751 0.381335043911309 no 1278 0.446398606409645 2032 1118244
SGTC_2904 7225135 42.03 µM 0.133966643372756 0.381677720291862 no 1279 0.446714475677115 2177 4446116
SGTC_841 0251-0215 91.2 µM 0.132460596282138 0.382323931338698 no 1280 0.447309993975597 2100 3888614
SGTC_1275 0867-0008 21.1 µM 0.132445928144519 0.382330226722861 no 1281 0.447315794609272 2092 3422836
SGTC_49 0717-0965 32.132 µM 0.132410084030122 0.382345610706534 no 1282 0.447329969501674 2121 5889349 YGL099W LSG1
SGTC_528 3492-0019 172 µM 0.132313148462466 0.382387215543354 no 1283 0.44736830392119 2173 2869262
SGTC_258 haloperidol 50.781 µM 0.132008947838252 0.382517787551401 no 1284 0.447488607169396 2000 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1338 1486-1223 76 µM 0.131398426296602 0.382779881951831 no 1285 0.447730066751966 2138 3444526
SGTC_250 brefeldin a 552.239 µM 0.130143898727144 0.383318613893203 no 1286 0.448226289639533 2089 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1451 4152-0210 104 µM 0.129504773261624 0.383593160478348 no 1287 0.448479124121391 2166 659563
SGTC_1651 st011928 86.1 µM 0.128571166197931 0.38399431137766 no 1288 0.448848491472131 2134 720198
SGTC_1787 fluconazole 80 µM 0.12827952685735 0.384119648041061 no 1289 0.44896388321882 2108 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2474 5321570 43.32 µM 0.126905500463514 0.384710320680946 no 1290 0.449507596551907 2165 2841384
SGTC_236 1509-0011 5.31 µM 0.125854477029715 0.385162320149704 no 1291 0.449923559062746 2154 3107280
SGTC_3031 9088762 49.47 µM 0.124473783663112 0.385756333412723 no 1292 0.450470078268606 2185 205253
SGTC_2308 7584454 197.62 µM 0.122247903508883 0.386714533684328 no 1293 0.451351344705677 2164 893577
SGTC_2335 9018011 154.17 µM 0.121836205818622 0.386891837830412 no 1294 0.451514369719293 2159 6458208
SGTC_2274 7947094 46.08 µM 0.121521099118726 0.387027559484348 no 1295 0.451639151932922 2220 2971028
SGTC_2214 7179297 48.276 µM 0.12108501481227 0.387215410973474 no 1296 0.451811849143168 2134 769744
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.120538423879656 0.387450902563344 no 1297 0.452028321834708 2201 1273210
SGTC_937 3122-0005 46.7 µM 0.119231342377244 0.38801420941222 no 1298 0.452546038064956 2196 759535
SGTC_141 0443-0274 32.331 µM 0.119058120232219 0.38808887987078 no 1299 0.45261465494561 2200 1627241
SGTC_3112 9123419 49.47 µM 0.118411202335524 0.388367781790906 no 1300 0.452870925022877 2221 17015854
SGTC_270 tamoxifen 5.46 µM 0.118101728968187 0.388501223596199 no 1301 0.452993526761522 2218 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_475 α-linolenic acid 10 µM 0.117387413365359 0.388809279524604 no 1302 0.453276528895806 2193 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1394 3474-0001 65.7 µM 0.115730135128523 0.389524266783955 no 1303 0.453933211169171 2115 5017666 YIL048W NEO1
SGTC_2973 9094665 17.96 µM 0.114917238580318 0.389875105619894 no 1304 0.454255360602877 2186 25237061 YIL048W NEO1
SGTC_1175 0741-0056 27.6 µM 0.11372944147788 0.390387909458217 no 1305 0.4547261365063 2186 765927
SGTC_2393 9031399 185.94 µM 0.113157379155274 0.390634952206659 no 1306 0.45495289253832 2173 1526623 YDL150W RPC53
SGTC_809 3998-0021 90 µM 0.112007702074609 0.39113156894025 no 1307 0.455408649815402 2222 715485
SGTC_2869 9037858 32.47 µM 0.111818984929597 0.391213104549373 no 1308 0.455483467065443 2236 27187042
SGTC_3058 9093861 49.47 µM 0.111002067997728 0.391566110196843 no 1309 0.455807353421626 2165 17217477
SGTC_1550 gossypolone 36.6 µM 0.110060911563921 0.391972912847829 no 1310 0.456180533912773 2213 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3167 9103034 49.47 µM 0.108889016247151 0.392479614453669 no 1311 0.456645259302952 2201 5127859
SGTC_1627 st003713 25.6 µM 0.107643189220781 0.393018482424546 no 1312 0.457139367983922 2111 16195070 YER133W GLC7
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.10630883978189 0.393595867166467 no 1313 0.457668659102936 2202 94937 An inhibitor of serotonin biosynthesis.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.105795540263567 0.393818038786319 no 1314 0.457872287643331 2206 4620898
SGTC_1807 st050092 58.9 µM 0.105471101363118 0.393958483628736 no 1315 0.458000999919161 2133 5008496
SGTC_3094 9117742 49.47 µM 0.105195905912514 0.394077622515615 no 1316 0.458110179653692 2238 17149698
SGTC_2191 5911152 200 µM 0.104463730267989 0.394394647623017 no 1317 0.458400674906887 2218 2875902
SGTC_3301 9125354 19.7965 µM 0.103354365301019 0.394875125383347 no 1318 0.458840864663832 2181 41905162
SGTC_1496 4469-0713 57.4 µM 0.102981215220563 0.395036776629666 no 1319 0.45898893988026 2223 746691
SGTC_2810 7959871 45.46 µM 0.102754063744684 0.395135189099801 no 1320 0.459079082013118 2176 2974535
SGTC_2718 lomofungin 53.02 µM 0.102238119004673 0.395358744942544 no 1321 0.459283835836954 2189 5351222 A RNA synthesis inhibitor.
SGTC_452 diindolylmethane 8 µM 0.101193968072475 0.395811274752513 no 1322 0.459698242460446 2171 3071 Inhibits expression of several cancer promoting factors.
SGTC_1735 st034310 56.75 µM 0.101135234610495 0.395836733720901 no 1323 0.459721554126949 2144 871153
SGTC_2961 9083290 32.55 µM 0.0993452799554764 0.396612831149029 no 1324 0.460432064001997 2241 17741490
SGTC_1211 1056-0033 32.3 µM 0.0989068145293312 0.396803005766537 no 1325 0.46060612911384 2235 6741922
SGTC_2137 5261020 140 µM 0.0982355879302654 0.397094182898982 no 1326 0.460872612017676 2201 763655
SGTC_2156 5649887 115 µM 0.0979900023219369 0.397200731926163 no 1327 0.46097011607596 2209 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0959557396470836 0.398083605249357 no 1328 0.461777862467519 2091 2374 Ca(2+)-ATPase inhibitor.
SGTC_3284 9108171 64.8615 µM 0.0947087875092663 0.398625042905324 no 1329 0.4622730689666 2147 8687505
SGTC_1920 st075728 45.7 µM 0.0937600876302223 0.399037107585701 no 1330 0.462649868710834 2250 3400306
SGTC_829 1635-0120 117 µM 0.0937441296697518 0.399044039837177 no 1331 0.462656207099178 2238 285054
SGTC_981 1488-1094 54.9 µM 0.0933265451830512 0.399225452818946 no 1332 0.462822072051511 2216 3449522
SGTC_247 mechlorethamine 29.705 µM 0.0928624654608202 0.399427090455585 no 1333 0.463006412537892 2161 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2367 9070478 135.38 µM 0.0927795774997276 0.399463107206755 no 1334 0.46303933790591 2201 572802
SGTC_2935 9038016 29.96 µM 0.0923353793390156 0.399656136233697 no 1335 0.463215789888495 2250 6463195
SGTC_2684 capsaicin 100 µM 0.0919690379181132 0.399815350596441 no 1336 0.463361319733959 2189 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_531 3788-1495 174 µM 0.0918913747750798 0.399849105644123 no 1337 0.463392172199897 2115 2896655
SGTC_1353 1498-1206 8.11 µM 0.0904748336654694 0.40046491374114 no 1338 0.463954945872846 2223 6756808
SGTC_1996 st072960 66.8 µM 0.0889891876674484 0.401111029472118 no 1339 0.464545251509413 2272 1719405
SGTC_3142 9086498 49.47 µM 0.0888300457300554 0.401180257262074 no 1340 0.464608489516464 2261 25236367
SGTC_1889 st059080 5.18 µM 0.0877372479143035 0.40165571519347 no 1341 0.46504275710447 2265 176925 Isolated from Daphnopsis sellowiana.
SGTC_3317 9138495 8.753 µM 0.0863039963455173 0.402279519455614 no 1342 0.465612380853736 2260 17020139
SGTC_2739 tacrine 100.86 µM 0.0851162430813698 0.402796662466157 no 1343 0.466084488528644 2190 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1827 berberine 7.24 µM 0.0850071432944207 0.402844172619837 no 1344 0.46612785587026 2148 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3169 9102970 49.47 µM 0.0840141434510163 0.403276664403231 no 1345 0.466522593339038 2270 17027839
SGTC_2525 harmine 47.85 µM 0.0836563255262913 0.403432537680433 no 1346 0.466664841273881 2215 5280953 A monoamine oxidase inhibitor
SGTC_2918 7977171 22.06 µM 0.0830151013088417 0.403711907274033 no 1347 0.466919765976622 2265 2236483
SGTC_320 4092-0846 5.34 µM 0.0826882938567056 0.403854310178409 no 1348 0.467049696572049 2246 1359356
SGTC_3005 9076496 71.4286 µM 0.0825467190384424 0.403916003871377 no 1349 0.467105984324357 2279 21368410
SGTC_1911 st060208 74.3 µM 0.0819627198796168 0.404170516926304 no 1350 0.467338179449704 2225 688783
SGTC_1724 st037281 8.293 µM 0.0806308561414675 0.404751108926808 no 1351 0.467867763218804 2220 574124 YDL195W SEC31
SGTC_3221 9128209 49.47 µM 0.0804464549107297 0.404831510496727 no 1352 0.467941090462465 2204 16460723
SGTC_3003 9075612 71.4286 µM 0.0793356102320671 0.405315939530884 no 1353 0.468382841342718 2199 6501993
SGTC_1515 3460-0031 42.1 µM 0.078212776910255 0.405805744151142 no 1354 0.468829399324042 2222 2876596
SGTC_1251 0490-5699 265 µM 0.0774361889218665 0.406144595267693 no 1355 0.469138276301681 2270 3883818
SGTC_1019 4262-0212 3.4 µM 0.0749277452545238 0.407239591649772 no 1356 0.470136100540153 2290 4677213
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.074397358024936 0.407471211698067 no 1357 0.470347105484994 2256 6710655
SGTC_1562 morin hydrate 59.1 µM 0.0743199163573094 0.407505033174965 no 1358 0.470377914946675 2210 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3044 9093193 49.47 µM 0.0737960270609901 0.407733851997402 no 1359 0.470586344176698 2177 25236277
SGTC_1781 st038725 66.3 µM 0.0723351745748102 0.408372073722138 no 1360 0.471167586370204 2131 4270275 YIL048W NEO1
SGTC_523 1934-0222 13.7 µM 0.0705650086288433 0.409145754915209 no 1361 0.471871980015446 2258 1361595
SGTC_2565 isoliquiritigenin 100 µM 0.0694112274831463 0.409650225421437 no 1362 0.472331146118048 2061 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3181 9108277 49.47 µM 0.0692356792642032 0.409726993926153 no 1363 0.472401011645067 2259 17097298
SGTC_3111 9122088 49.47 µM 0.0674712416233477 0.410498786991133 no 1364 0.473103277849982 2288 16876704
SGTC_1829 berberine 14.4 µM 0.0654644601552394 0.411377006395217 no 1365 0.473902101150211 2292 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1504 k297-0033 30 µM 0.0648717450257999 0.411636479027423 no 1366 0.474138058697905 2277 4388117
SGTC_2390 9097792 176.6 µM 0.0643283125890478 0.411874411162009 no 1367 0.474354404975298 2150 4497149
SGTC_3157 9099274 49.47 µM 0.0639108281474205 0.412057221242022 no 1368 0.474520615146305 2288 17217662
SGTC_1665 st014639 11.4 µM 0.0632853488024198 0.412331144829239 no 1369 0.474769641169023 2299 981133 YIL048W NEO1
SGTC_843 0310-0051 143 µM 0.0624491180542362 0.41269743197934 no 1370 0.475102590354719 2179 2065037
SGTC_3276 9139060 49.47 µM 0.0616355020189763 0.413053886378378 no 1371 0.475426552077343 2317 4870619
SGTC_1442 4112-3290 3 µM 0.0615655720187906 0.413084526853337 no 1372 0.475454397229957 2298 704353
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0612124837425002 0.413239243822128 no 1373 0.475594993894405 2290 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1195 1502-0147 41.1 µM 0.0611735100463251 0.413256322225044 no 1374 0.475610513066002 2284 817940
SGTC_180 1486-1293 102.781 µM 0.0608684857993523 0.413389990528505 no 1375 0.475731973790281 2307 4140536
SGTC_2807 7945238 51.95 µM 0.0598609954068273 0.413831566136258 no 1376 0.476133172657066 2258 17148797
SGTC_2679 rapamycin 1 nM 0.0598295519166676 0.413845349342607 no 1377 0.476145694351691 2249 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2737 bleomycin 30.5 nM 0.0595319331933 0.413975815314244 no 1378 0.476264215781101 2291 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_263 alizarin 107.927 µM 0.0594415167558687 0.414015452700199 no 1379 0.476300222955666 2305 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_781 4335-2806 94.4 µM 0.0570395810151393 0.415068749469815 no 1380 0.477256832679641 2290 845254
SGTC_2747 doxorubicin 7.63 µM 0.0566804653458773 0.415226281527635 no 1381 0.477399867695354 2316 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1048 3161-0300 24.5 µM 0.0539381114950823 0.416429708280198 no 1382 0.478492236132369 2304 2165101
SGTC_1915 st067105 30.6 µM 0.0538583605779504 0.416464717146187 no 1383 0.478524005965577 2303 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1850 st056238 17 µM 0.0533254810303451 0.416698656323059 no 1384 0.478736289077454 2306 5393177
SGTC_2705 st078069 42.8 µM 0.0523461440054274 0.417128671449406 no 1385 0.47912644304623 2268 1530061
SGTC_295 k015-0027 31 µM 0.0520344917793746 0.417265535020709 no 1386 0.479250605082186 2257 3887424
SGTC_790 1575-0012 79.1 µM 0.0515654445426774 0.41747153826004 no 1387 0.479437476975684 2318 378741 YLR208W SEC13
SGTC_1425 4048-4433 7.33 µM 0.0508027120083072 0.417806574983907 no 1388 0.479741364899807 2319 23734946
SGTC_2450 5739737 12.93 µM 0.0493426548296235 0.418448083691081 no 1389 0.480323113629625 2250 2262825
SGTC_622 1348-1566 26.3 µM 0.0493247193187761 0.418455965410553 no 1390 0.480330260161269 2273 7340407
SGTC_1164 k060-0068 93.7 µM 0.0489554449268563 0.418618249474553 no 1391 0.480477401566467 2325 5963676
SGTC_1293 1000-1278 195 µM 0.0484958740773651 0.418820235233207 no 1392 0.480660526292043 2283 678847
SGTC_262 fenpropimorph 62.5 µM 0.0484548522789338 0.418838265744946 no 1393 0.480676872405021 2310 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_635 k038-0028 24.7 µM 0.0483457158389023 0.418886235848362 no 1394 0.480720360577993 2271 4035102
SGTC_1518 st038567 90.8 µM 0.0482604916730704 0.418923696329695 no 1395 0.480754320460501 2312 77966
SGTC_1086 cerivastatin 2.18 µM 0.0475436343523228 0.419238821705245 no 1396 0.481039977225477 2338 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2827 7993847 71.43 µM 0.0471337079152654 0.419419045747627 no 1397 0.481203331075463 2278 2985692
SGTC_1786 berberine 21.6 µM 0.0468493940719774 0.419544054179959 no 1398 0.481316630724514 2331 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1944 st076371 56.9 µM 0.046516033828086 0.419690637903236 no 1399 0.481449477386143 2283 24208455
SGTC_1162 k048-0130 20.1 µM 0.0464262593613914 0.419730115048536 no 1400 0.481485253565196 2281 6797406
SGTC_205 1486-1330 71.903 µM 0.045378040756854 0.420191115122975 no 1401 0.48190299194572 2310 4118834
SGTC_1265 0819-1001 68.8 µM 0.0450865887545903 0.420319313399797 no 1402 0.482019145587936 2334 3106768
SGTC_1307 1187-1599 12.2 µM 0.0441479188520783 0.420732254771937 no 1403 0.482393248137442 2273 1538471
SGTC_1231 0242-0792 125 µM 0.0430883861460067 0.421198471119722 no 1404 0.482815538607562 2309 3707635
SGTC_2283 7944793 200 µM 0.0428661188634409 0.421296287375328 no 1405 0.482904128571364 2303 2970533
SGTC_2060 5238662 140 µM 0.0417486735292203 0.421788130573099 no 1406 0.483349525947751 2263 790130
SGTC_966 1300-0360 30.2 µM 0.0409018308578389 0.422160949421592 no 1407 0.483687078928522 2316 70588
SGTC_557 1315-0110 16.2 µM 0.0386215078579107 0.423165197749391 no 1408 0.484596077146587 2339 6833801
SGTC_2270 7924575 90.91 µM 0.0386085638796501 0.423170899675446 no 1409 0.484601237198227 2351 1262135
SGTC_969 1313-0238 134 µM 0.0370519918280362 0.423856699112438 no 1410 0.485221775345244 2313 5212874
SGTC_2304 7443016 91.4 µM 0.0365646483420264 0.424071461961052 no 1411 0.485416065603066 2337 939854
SGTC_1326 1431-2094 10.8 µM 0.035455278624579 0.424560423733945 no 1412 0.485858353211271 2339 616278
SGTC_2801 7907800 81.82 µM 0.0352401685797495 0.424655248320801 no 1413 0.485944116107467 2321 6620925
SGTC_2012 4023501 200 µM 0.0351963875982833 0.424674548341878 no 1414 0.485961571363579 2303 3477460
SGTC_3251 9135047 49.47 µM 0.0349399613257186 0.42478759265926 no 1415 0.486063807761921 2344 17682963
SGTC_1377 2944-0135 198 µM 0.0340229900483516 0.425191885685548 no 1416 0.486429408952139 2323 1894137
SGTC_144 4161-2749 112.381 µM 0.0332981186950803 0.425511537480891 no 1417 0.486718426996619 2331 797501 YMR168C CEP3
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0315778383892407 0.426270337626537 no 1418 0.487404358489019 2343 66535 A nucleotide analog.
SGTC_686 1319-0111 510 µM 0.0313744534474482 0.426360066994392 no 1419 0.487485457157244 2342 4562600
SGTC_3178 9107506 49.47 µM 0.0311680588718596 0.426451128049491 no 1420 0.487567756430028 2331 8897194
SGTC_721 1187-1332 279 µM 0.0304893439861801 0.426750603916642 no 1421 0.487838395849461 2335 25730
SGTC_1884 5633444 25 µM 0.0302287276599563 0.426865609384155 no 1422 0.487942318818228 2321 5724239
SGTC_1487 3970-0795 2.82 µM 0.029265361867333 0.427290779903161 no 1423 0.488326476144094 2295 3765103
SGTC_384 k007-0144 5.16 µM 0.0276493714612633 0.428004168304318 no 1424 0.488970901983852 2316 6824886
SGTC_1899 st063254 59.6 µM 0.0252954409809947 0.429043745229538 no 1425 0.489909655169644 2362 3093813
SGTC_774 k060-0086 136 µM 0.0243026864450139 0.42948232792914 no 1426 0.490305585145939 2358 5911235
SGTC_1082 camptothecin 424.86 nM 0.0240043384615752 0.429614150220247 no 1427 0.490424574056703 2372 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1213 1315-0166 115 µM 0.0237780191170214 0.429714152560473 no 1428 0.490514836647828 2286 768401
SGTC_3285 9112818 20.8695 µM 0.0222576439416003 0.430386068012599 no 1429 0.491121217871087 2363 17017947 YPR165W RHO1
SGTC_3017 9080681 49.47 µM 0.0209194096959988 0.430977654900993 no 1430 0.491654971656583 2320 16451914
SGTC_1115 galangin 695.678 nM 0.0208661711617147 0.431001193020732 no 1431 0.491676206123833 2376 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1159 4092-0538 61.2 µM 0.0206875950547597 0.431080147881226 no 1432 0.491747432307993 2369 717301
SGTC_2529 gangaleoidin 93.61 µM 0.0206523184119672 0.431095745267992 no 1433 0.491761502646236 2368 4565183
SGTC_2944 9067346 25.62 µM 0.0197223690569294 0.431506956291033 no 1434 0.492132423161124 2354 6473075
SGTC_2026 5148700 152 µM 0.0195546895106139 0.431581109830659 no 1435 0.492199304723219 2362 79838
SGTC_2268 7933382 153.85 µM 0.0181011178399747 0.432224028925258 no 1436 0.492779093095512 2383 935025 YOR257W CDC31
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0169730342593996 0.432723107476397 no 1437 0.493229064108378 2347 5282362
SGTC_1974 st069448 26.9 µM 0.0166070126854329 0.432885063188114 no 1438 0.493375065008324 2371 6323587 YNR016C ACC1
SGTC_3086 9117350 49.47 µM 0.0161098901573612 0.433105045957349 no 1439 0.493573361667508 2384 2679265
SGTC_863 0466-0191 129 µM 0.0154377903439278 0.433402491251975 no 1440 0.493841457339633 2380 765160 YPR165W RHO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0149029246054596 0.433639229036961 no 1441 0.494054813342242 2375 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3079 9117512 49.47 µM 0.0142825324436097 0.433913851629062 no 1442 0.494302287651117 2387 7185044
SGTC_3210 9128157 49.47 µM 0.0142351424128864 0.433934830597816 no 1443 0.494321191616218 2314 17590849
SGTC_1299 1079-1439 3.74 µM 0.0141903168254537 0.43395467449114 no 1444 0.494339072632199 2374 323161
SGTC_2763 lisinopril 49.32 µM 0.013848084457522 0.434106183233525 no 1445 0.494475590176721 2387 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2940 9060638 45.86 µM 0.0131239239681687 0.434426806202 no 1446 0.49476446213731 2356 4027022
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0127304042326394 0.434601055663183 no 1447 0.494921440679958 2372 521171
SGTC_3213 9129884 49.47 µM 0.0126408377897908 0.434640717214905 no 1448 0.494957169645947 2375 17190742
SGTC_480 am 92016 50 µM 0.011635236011664 0.435086059927854 no 1449 0.495358317143579 2359 2129 K+ channel blocker.
SGTC_2344 7990960 76.95 µM 0.0111514435039351 0.435300342573661 no 1450 0.495551309901545 2377 140813
SGTC_1081 sertraline 6 µM 0.0107162773070372 0.435493103760335 no 1451 0.49572490571818 2392 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_872 0588-0139 234 µM 0.00956992810417864 0.436000963775979 no 1452 0.496182209333384 2387 2047100
SGTC_1151 3909-8316 15.3 µM 0.00902917024565256 0.436240569081971 no 1453 0.496397931175793 2343 800431
SGTC_486 niguldipine 82 µM 0.00837674221378494 0.436529685651647 no 1454 0.49665820244116 2388 1236 A calcium channel blocker.
SGTC_1128 3448-9350 235 µM 0.00830520825468867 0.436561387233293 no 1455 0.496686739369221 2361 619386
SGTC_1276 0871-0068 94.2 µM 0.00685392733557033 0.43720463661317 no 1456 0.49726570000695 2392 3414906
SGTC_471 1-acyl-paf 4 µM 0.00674877654046105 0.437251248936146 no 1457 0.49730764813468 2387 16759367
SGTC_3212 9128307 49.47 µM 0.00600371865596497 0.437581550750416 no 1458 0.497604877177065 2380 27243542
SGTC_1608 st001473 40.5 µM 0.00572726160585744 0.437704121789088 no 1459 0.497715165685519 2396 7292267
SGTC_206 4546-0025 72.014 µM 0.0051234734280295 0.437971840358348 no 1460 0.497956038769373 2385 6620745 YIL048W NEO1
SGTC_2834 9001755 58.44 µM 0.00493371869091344 0.438055983129946 no 1461 0.498031738999688 2378 2989575
SGTC_2018 5133068 143 µM 0.00442334305780626 0.438282312422057 no 1462 0.498235347188045 2396 785362
SGTC_2731 amoxapine 43.43 µM 0.00440850736606974 0.438288891705382 no 1463 0.498241265715031 2397 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2714 st079313 56.9 µM 0.00400905938376662 0.438466043976853 no 1464 0.498400620991528 2399 2939799
SGTC_1438 4092-1045 4 µM 0.0022756292350043 0.439234950025099 no 1465 0.499092156067182 2400 1351342
SGTC_1342 1486-1464 234 µM 0.001316738484921 0.439660388566447 no 1466 0.499474697497928 2403 3253938
SGTC_1502 4534-4282 27.7 µM 0.000731446138338312 0.439920104073095 no 1467 0.4997081952356 2404 3278949
SGTC_1046 2001-0062 216 µM 0.000379136866317287 0.440076448986913 no 1468 0.499848746277591 2401 739778
SGTC_1403 3909-7815 62.9 µM -0.0001244837459606 0.440299957824108 no 1469 0.499950338170642 2406 6615483
SGTC_290 2043-6722 48.1 µM -0.000203215924962751 0.440334901200618 no 1470 0.499918928576039 2406 773758 YLR208W SEC13
SGTC_451 chloral hydrate 100 µM -0.000877974977022062 0.440634395741597 no 1471 0.499649738705531 2407 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_555 4296-0685 37 µM -0.00213871344480258 0.441194070500985 no 1472 0.499146777431659 2410 2908540 YHR072W ERG7
SGTC_2317 5986382 200 µM -0.00258927007533119 0.441394112913298 no 1473 0.498967031845797 2413 877883
SGTC_1026 k007-1105 30.6 µM -0.00329102375778845 0.441705713939332 no 1474 0.498687073847228 2406 7066794
SGTC_427 1354-0053 47.3 µM -0.00386188980540767 0.441959223302036 no 1475 0.498459332704007 2429 6813657
SGTC_775 4577-0580 57.3 µM -0.00601572274394673 0.44291590750729 no 1476 0.497600088325311 2426 2006902
SGTC_2822 7994718 71.43 µM -0.00638965003282259 0.443082031680283 no 1477 0.497450915790461 2418 1018011
SGTC_3243 9134147 49.47 µM -0.00686170146266455 0.443291763618475 no 1478 0.497262598651888 2420 24282180
SGTC_1005 4092-0690 4.4 µM -0.00834822016559831 0.443952325789393 no 1479 0.496669580694251 2429 1529343
SGTC_1463 k081-0032 34.1 µM -0.00927101809049374 0.444362466638418 no 1480 0.496301451884208 2407 977755
SGTC_936 3005-4620 401 µM -0.00978209704357402 0.444589643179703 no 1481 0.496097570135304 2422 777207
SGTC_178 4092-0806 87.505 µM -0.00979092028789365 0.444593565305466 no 1482 0.496094050338655 2425 2169044
SGTC_97 0535-0701 19.132 µM -0.0101345770329606 0.4447463324885 no 1483 0.495956957937592 2431 2832013 YGL099W LSG1
SGTC_1795 st049545 62.3 µM -0.0101729242026935 0.444763379627108 no 1484 0.49594166041885 2422 5291882
SGTC_2418 pentamidine 31.67 µM -0.0110279716295708 0.445143515305421 no 1485 0.495600565023808 2419 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_53 0973-0023 39.979 µM -0.0117916024450212 0.445483051783261 no 1486 0.495295940241474 2430 674768
SGTC_712 r015-0009 80.6 µM -0.0119770855382067 0.445565529980652 no 1487 0.495221948418808 2429 6813872 YLR060W FRS1
SGTC_1443 4112-3303 14 µM -0.0120289812676839 0.445588606717244 no 1488 0.495201246509494 2431 704433
SGTC_288 1315-0019 35.1 µM -0.0132188750181497 0.446117773207803 no 1489 0.494726585434595 2438 6811474
SGTC_2872 9044037 25.97 µM -0.0144271045596798 0.446655192153895 no 1490 0.494244617663568 2436 6465195
SGTC_783 0848-0141 92.7 µM -0.0145707915297109 0.446719110472033 no 1491 0.494187300880999 2428 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2104 5389443 200 µM -0.0149516076018829 0.446888520992154 no 1492 0.494035393800318 2443 2244536
SGTC_171 k064-0041 9.68 µM -0.015669309194506 0.447207825330585 no 1493 0.493749105852818 2430 53325
SGTC_2431 5490079 200 µM -0.0156815660099345 0.447213278666772 no 1494 0.493744216691638 2445 5722345
SGTC_1078 idebenone 36.1 µM -0.0162827686402638 0.447480779632568 no 1495 0.493504402176749 2458 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1930 st074634 34.3 µM -0.0168922266951559 0.447751978177325 no 1496 0.493261297041175 2430 684253 YOR116C RPO31
SGTC_859 0439-0102 54.6 µM -0.0195417700178143 0.448931262516156 no 1497 0.492204457870449 2441 610143
SGTC_3153 9100258 49.47 µM -0.0204997315140499 0.449357752907702 no 1498 0.491822363126492 2453 25236848
SGTC_2870 9038528 12.99 µM -0.0215883343655048 0.449842476640795 no 1499 0.49138816959615 2535 6463316
SGTC_3159 9100096 49.47 µM -0.0218771578120369 0.449971094058501 no 1500 0.491272972919771 2436 25236875
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0222324480376586 0.450129317338096 no 1501 0.491131267095765 2468 115019
SGTC_643 k048-0106 28.4 µM -0.0223700310875549 0.450190590057716 no 1502 0.49107639304751 2484 6763920
SGTC_725 1497-0963 19 µM -0.022911692410866 0.450431830879753 no 1503 0.490860356824735 2446 3549977
SGTC_94 0334-0113 514.748 µM -0.0231938038056883 0.450557482673338 no 1504 0.490747840563116 2447 6795178
SGTC_735 3076-0345 636 µM -0.0234547072978822 0.450673692924975 no 1505 0.490643783437745 2460 2888990
SGTC_3330 9141424 71.43 µM -0.024394925080015 0.451092514756835 no 1506 0.490268798161026 2455 27261020
SGTC_609 0986-0026 86.3 µM -0.0254532723358843 0.451564022716554 no 1507 0.48984670983626 2446 2848610
SGTC_595 3909-8003 73.7 µM -0.0256906200163978 0.451669773710598 no 1508 0.489752052765916 2467 699517
SGTC_2809 7964133 12.99 µM -0.0272077379775412 0.452345811024928 no 1509 0.489147021989262 2471 1253665
SGTC_2017 5132927 60.65 µM -0.027400717960855 0.4524318140675 no 1510 0.489070062807452 2475 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1738 st035555 74 µM -0.0277838494801112 0.452602566243097 no 1511 0.488917273619283 2477 5331140
SGTC_254 nsc-64875 3.808 µM -0.0281988672516182 0.452787539216697 no 1512 0.488751770334247 2458 56993
SGTC_2719 novobiocin 32.65 µM -0.0282389180081067 0.452805390338438 no 1513 0.488735798754521 2459 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2177 5811945 192 µM -0.0283759172887672 0.452866453347648 no 1514 0.488681165842456 2479 5343475
SGTC_614 0462-0418 107 µM -0.0286351328246717 0.452981993357994 no 1515 0.488577795811701 2453 5188303
SGTC_1685 st024049 53.0905 µM -0.0290339170239072 0.453159751007755 no 1516 0.488418770058044 2493 1941139
SGTC_311 1315-0136 58 µM -0.0299235914206304 0.453556356238316 no 1517 0.488063995519585 2477 6759207
SGTC_1452 4194-0072 190 µM -0.029982708076681 0.453582711317441 no 1518 0.48804042196338 2455 1343545
SGTC_1424 4048-1941 275 µM -0.0305892009647324 0.453853106598127 no 1519 0.487798577251422 2500 X1424
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0327676979386263 0.454824530619891 no 1520 0.486929918841712 2474 6857784
SGTC_3199 9111318 49.47 µM -0.0329180722048871 0.454891594765965 no 1521 0.486869960534961 2495 8548020
SGTC_361 000s-0510 1.45 µM -0.0335205274357643 0.455160291549477 no 1522 0.486629748251273 2492 660
SGTC_1157 4092-0394 27.6 µM -0.0336430888618787 0.455214956816892 no 1523 0.486580880879043 2556 3659885
SGTC_699 0375-0592 111 µM -0.0337624083776644 0.455268176931026 no 1524 0.486533306306411 2461 762578
SGTC_2629 bisabolol 100 µM -0.034256251881516 0.4554884546021 no 1525 0.48633640515909 2483 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_134 0269-0018 6.916 µM -0.0344077204613806 0.455556019532245 no 1526 0.486276013540333 2505 4378915
SGTC_1253 0550-0034 176 µM -0.03444860263357 0.455574255885228 no 1527 0.486259713576356 2510 5969915
SGTC_335 4077-0256 27.6 µM -0.0345181988391233 0.455605300952165 no 1528 0.486231965210176 2540 3121989
SGTC_543 3844-1095 191 µM -0.034601035051786 0.4556422523971 no 1529 0.48619893807176 2505 4230703
SGTC_268 camptothecin 39.6153 µM -0.0359667242383281 0.45625151191573 no 1530 0.485654445994455 2469 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1628 st004252 77.7 µM -0.037469797243776 0.456922179793948 no 1531 0.485055210768264 2497 692968
SGTC_2708 st078559 56 µM -0.0377228909652187 0.457035121780862 no 1532 0.484954312316579 2468 17250902
SGTC_2237 6667747 47.222 µM -0.0379882475365875 0.457153539738534 no 1533 0.484848526186445 2518 729940 YDL015C TSC13
SGTC_1917 st066507 28.5 µM -0.0383255963854551 0.457304090443489 no 1534 0.484714041405274 2452 3156428
SGTC_2628 lathosterol 100 µM -0.0390880318017597 0.457644369634482 no 1535 0.484410101458359 2518 6710616
SGTC_808 0711-0032 135 µM -0.0397848107707717 0.457955373147324 no 1536 0.484132342946509 2461 4252555
SGTC_3320 9137005 35.139 µM -0.0410932144225054 0.458539441429854 no 1537 0.483610792071221 2504 4908713
SGTC_848 0368-0089 85.6 µM -0.04125357348483 0.458611031518148 no 1538 0.483546872264226 2486 762535
SGTC_27 0485-0001 32.618 µM -0.0419085850357518 0.458903466293546 no 1539 0.483285786271697 2471 2054479
SGTC_1560 lithocholic acid 53.1 µM -0.0459724704129555 0.460718309095992 no 1540 0.481666096065112 2490 9903 A bile acid which acts as a detergent.
SGTC_1319 1306-0155 43.7 µM -0.0468597624757623 0.461114664604883 no 1541 0.481312498867793 2492 3122360
SGTC_526 4469-0568 170 µM -0.0471367488350559 0.461238403011431 no 1542 0.481202119270886 2486 2901964
SGTC_1226 3909-7979 35.4 µM -0.0476241873825163 0.461456166050042 no 1543 0.481007877576976 2554 6615510
SGTC_81 0411-0046 9.971 µM -0.0490501945696122 0.462093300493962 no 1544 0.480439647284388 2479 12925265
SGTC_1552 6-methylflavone 10.6 µM -0.0514718053723295 0.463175488758438 no 1545 0.479474784057313 2511 689013
SGTC_2375 9072683 200 µM -0.0515422562318278 0.463206976505393 no 1546 0.479446715488074 2487 16798029
SGTC_448 monastrol 171 µM -0.0526384632171923 0.463696951674685 no 1547 0.479009985110813 2506 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1840 st055363 71 µM -0.0537989766787544 0.464215730112941 no 1548 0.478547662416314 2552 676033
SGTC_2122 5258151 111.688 µM -0.0569535831215328 0.465626222757264 no 1549 0.477291085193669 2543 2173356
SGTC_484 loperamide 105 µM -0.0570126787749389 0.465652649876463 no 1550 0.477267547684034 2501 3955 An opioid-receptor agonist.
SGTC_125 0133-0007 11.75 µM -0.0570369521574999 0.465663504789323 no 1551 0.477257879737486 2573 26541
SGTC_1223 0764-0573 147 µM -0.0574472831609506 0.465847006242523 no 1552 0.477094449324799 2524 1609797
SGTC_1567 st069303 68.4 µM -0.0576556521375807 0.4659401923567 no 1553 0.477011459682076 2554 5581319
SGTC_2920 7982904 15.77 µM -0.0581835552451566 0.46617628786068 no 1554 0.476801209771514 2560 6456808
SGTC_870 0573-2213 57.6 µM -0.0592459180724547 0.466651447196885 no 1555 0.476378118258477 2506 3916321
SGTC_518 1021-0119 62.6 µM -0.0592677884618656 0.466661229591752 no 1556 0.476369408540425 2548 1097762
SGTC_225 nsc-122657 1.016 µM -0.0605126419979009 0.467218072485564 no 1557 0.475873673721864 2619 275685
SGTC_1179 1021-1431 9.29 µM -0.0624423375636478 0.468081382599258 no 1558 0.475105290110155 2588 2840958
SGTC_3220 9131269 49.47 µM -0.0635126274717117 0.468560275501666 no 1559 0.474679152138705 2506 17722206
SGTC_1450 4112-4260 37.6 µM -0.064043245631009 0.468797713385938 no 1560 0.47446789621486 2508 1633175
SGTC_1199 1638-0010 4.46 µM -0.0640654103014622 0.468807631744008 no 1561 0.474459071912134 2524 3111136
SGTC_591 4299-0174 154 µM -0.0643953290359329 0.468955267721836 no 1562 0.474327724599408 2560 5509088
SGTC_688 0527-0193 473 µM -0.0654139072741836 0.469411100130422 no 1563 0.473922225696157 2566 4007154
SGTC_221 trifluoperazine 10.304 µM -0.065951703522366 0.469651790008372 no 1564 0.47370813834667 2528 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2972 9093619 59.92 µM -0.0670843196943405 0.470158726788034 no 1565 0.473257288422004 2532 25236256
SGTC_1780 st038448 24.544 µM -0.0673630618459402 0.470283493755207 no 1566 0.47314633737146 2717 728868 YDL195W SEC31
SGTC_1979 st071809 45.3 µM -0.0676146872387509 0.470396125574342 no 1567 0.473046181715528 2647 4976333
SGTC_1922 5578187 25 µM -0.068418845736072 0.470756096473913 no 1568 0.472726110126836 2564 1350412
SGTC_912 3474-0017 2.18 µM -0.0686006927983948 0.470837501226036 no 1569 0.472653733697257 2616 3360550
SGTC_3204 9114183 49.47 µM -0.0688502917972827 0.470949237456871 no 1570 0.472554392983645 2526 17027248
SGTC_866 0495-0101 262 µM -0.0706356651957297 0.471748549190208 no 1571 0.471843862286037 2560 635694
SGTC_1008 4106-0037 6 µM -0.0713235533118453 0.472056547271202 no 1572 0.471570125065384 2518 2905394
SGTC_174 3553-0389 74.3 µM -0.072140473695862 0.472422340525019 no 1573 0.471245058382568 2610 738071
SGTC_2843 9000894 45.46 µM -0.0726284980193275 0.472640874780537 no 1574 0.471050874230205 2521 2242070
SGTC_2312 7706453 155.7 µM -0.0754441397227033 0.473901860407913 no 1575 0.469930670417695 2565 976098
SGTC_1455 4262-0120 131 µM -0.0756011018805494 0.473972163750781 no 1576 0.46986822990066 2729 1529587
SGTC_1524 corynanthine 62.1 µM -0.0761884039825929 0.474235223506843 no 1577 0.469634604077912 2720 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2581 avocatin a 64 µM -0.0765456382009028 0.474395238561221 no 1578 0.469492503210274 2590 6710728 A skin care supplement.
SGTC_1282 0886-0010 32.4 µM -0.0769614506634274 0.47458149762655 no 1579 0.469327105944127 2559 2836211 YNL267W PIK1
SGTC_1270 0831-1170 17.3 µM -0.0775487873616662 0.474844598727587 no 1580 0.469093490696141 2533 6764716
SGTC_165 k038-0023 64.381 µM -0.077634983745457 0.474883211855892 no 1581 0.469059206673222 2562 46368543
SGTC_3034 9090421 49.47 µM -0.0782897831694637 0.475176548012545 no 1582 0.4687987721841 2529 17173761
SGTC_920 mycophenolic acid 780.421 nM -0.0789619645280904 0.475477684899722 no 1583 0.468531438236463 2571 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2995 9067767 71.4286 µM -0.0792076651981314 0.475587762172852 no 1584 0.468433723902053 2611 11673567
SGTC_2190 6049624 200 µM -0.0792147224268526 0.475590923935768 no 1585 0.468430917293869 2531 2265554
SGTC_2376 9072922 81.32 µM -0.0805902137133328 0.47620719738647 no 1586 0.467883924607547 2674 17087968
SGTC_1256 0570-0116 285 µM -0.0808191121886151 0.476309758345837 no 1587 0.467792904230122 2577 410638
SGTC_881 0833-0569 170 µM -0.0812197411471492 0.476489269170341 no 1588 0.467633600107702 2556 5418700
SGTC_2287 7945887 168.79 µM -0.0820911009649977 0.476879717979568 no 1589 0.467287134820659 2592 1245853
SGTC_2406 ethylparaben 405.7 µM -0.0825262234512505 0.477074700941041 no 1590 0.467114133077576 2562 8434 A possible steroid mimic.
SGTC_1149 3909-7961 23.3 µM -0.0840016222527259 0.477735883238637 no 1591 0.466527570979002 2573 735261
SGTC_2098 5376439 882.5 nM -0.0842738616211988 0.477857890801826 no 1592 0.466419346931265 2647 2844116
SGTC_1527 coumarin 137 µM -0.084603395064037 0.478005578214242 no 1593 0.466288349938646 2788 323 A hepatotoxic, DNA x-linker.
SGTC_2741 miltefosine 3.04 µM -0.0848366050265737 0.478110098039179 no 1594 0.466195645912845 2577 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1032 k061-1018 98.7 µM -0.0851648011170554 0.478257191207552 no 1595 0.466065186760467 2758 4005393
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0869203947650177 0.479044074978628 no 1596 0.465367394097174 2628 688761
SGTC_2173 5763948 167 µM -0.0875517712889159 0.479327087669515 no 1597 0.465116467920853 2561 2867177
SGTC_117 lucigenin 22.078 µM -0.0882715324278875 0.479649731212595 no 1598 0.464830432222728 2583 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2756 carbadox 75.1 µM -0.0887976581139327 0.479885583256669 no 1599 0.464621359447305 2594 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_540 1187-0821 17.3 µM -0.0892858896945121 0.480104454402314 no 1600 0.464427353836203 2584 847520
SGTC_1835 st008666 49.2 µM -0.0906519379338941 0.480716876894799 no 1601 0.463884580642899 2580 690455
SGTC_1356 1502-0781 85.8 µM -0.0912745168570244 0.480996004724847 no 1602 0.463637233026554 2551 567702
SGTC_138 0850-0259 40.9225 µM -0.0913061951804939 0.481010207675144 no 1603 0.463624647755743 2570 6813004
SGTC_639 0833-0042 114 µM -0.0920160542304121 0.481328478685337 no 1604 0.463342642137335 2595 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1946 st076057 65.1 µM -0.092327994584968 0.481468343426506 no 1605 0.463218723447923 2571 953009
SGTC_2557 derrustone 83.84 µM -0.0924243979441986 0.481511568276616 no 1606 0.463180427816279 2680 629853 An antioxidant.
SGTC_1250 0485-0349 40.2 µM -0.0924881223711506 0.481540140831885 no 1607 0.463155113873439 2601 6842794 YDL195W SEC31
SGTC_2004 4023728 41.89 µM -0.0930166648794446 0.481777130676876 no 1608 0.462945160980538 2604 360084 YDR527W RBA50
SGTC_2646 retinol 96.75 µM -0.0936221098904798 0.482048610258976 no 1609 0.462704672800546 2641 445354 A vitamin A analog and teratogen.
SGTC_744 1594-0068 283 µM -0.0946407507067531 0.482505384222029 no 1610 0.46230009035142 2583 668392
SGTC_727 3032-0951 202 µM -0.0981415253419874 0.484075355938854 no 1611 0.46090995710468 2642 3652836
SGTC_1926 methyl fluorone black 53.6 µM -0.0988894729997829 0.484410816445918 no 1612 0.460613013632526 2572 72721 Reacts with homocysteine.
SGTC_1690 st023502 41.2 µM -0.0990551566044851 0.484485128369059 no 1613 0.460547238379091 2600 24207482
SGTC_1247 0448-0043 5.84 µM -0.099408632267309 0.484643670031778 no 1614 0.460406914578441 2665 3089013 YGL099W LSG1
SGTC_1163 k060-0048 49.9 µM -0.0995059861104524 0.484687335813841 no 1615 0.460368267630827 2574 6809982
SGTC_2385 9074692 200 µM -0.0996161191364466 0.484736733619866 no 1616 0.460324548130817 2608 17046906
SGTC_405 ebelactone b 50 µM -0.0998308018916198 0.48483302563657 no 1617 0.460239326911001 2608 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2819 7996655 46.38 µM -0.101108938330118 0.485406328436059 no 1618 0.459731991324653 2652 6456960
SGTC_2201 6605497 169.863 µM -0.102882168507052 0.486201753182953 no 1619 0.459028245031783 2634 670741
SGTC_3078 9116413 49.47 µM -0.102985076857482 0.486247916897361 no 1620 0.458987407457681 2568 17177322
SGTC_3353 9151644 39.2805 µM -0.104444337466566 0.486902546971566 no 1621 0.458408369424529 2681 4909158
SGTC_168 3970-0862 530.542 µM -0.10462795453778 0.486984920851362 no 1622 0.458335515965224 2652 3135186
SGTC_88 0180-0332 8.668 µM -0.104686397539745 0.487011139536851 no 1623 0.458312327919895 2565 3101745
SGTC_1622 st003707 19.4 µM -0.105356840866982 0.487311917648952 no 1624 0.458046330700843 2698 10140899
SGTC_60 0986-0278 202 µM -0.105739555298859 0.487483616428567 no 1625 0.457894497834538 2593 3110598
SGTC_1493 4348-0038 111 µM -0.105891655999146 0.487551854649227 no 1626 0.457834157197085 2593 800424
SGTC_1458 k015-0034 6.33 µM -0.105969934506724 0.487586973538796 no 1627 0.457803103313461 2621 3598957
SGTC_3043 9092303 49.47 µM -0.106512952236846 0.487830595786498 no 1628 0.457587689734359 2617 25236084
SGTC_1292 0kpi-0043 232 µM -0.106547179924757 0.487845952024297 no 1629 0.457574112125292 2636 3333905
SGTC_416 estradiol valerate 100 µM -0.106581024258093 0.487861136287945 no 1630 0.457560686635907 2649 13791 A steroid.
SGTC_446 go6976 132 µM -0.10665841059082 0.487895855740198 no 1631 0.457529988934786 2643 3501 A protein kinase C inhibitor.
SGTC_2813 7971799 71.43 µM -0.108041299329964 0.488516305313867 no 1632 0.456981465901611 2688 2234054
SGTC_7 0192-1582 4.227 µM -0.108072844414822 0.488530458723428 no 1633 0.456968954490844 2613 252616
SGTC_2476 5806916 10.51 µM -0.109499564139195 0.489170603339945 no 1634 0.456403133728888 2627 2870194
SGTC_2873 9040596 71.43 µM -0.110212790982438 0.489490626527047 no 1635 0.456120309168059 2712 6463863
SGTC_1819 st053448 58.6 µM -0.111780044146148 0.49019387277175 no 1636 0.455498905405355 2624 2857616
SGTC_2753 fluvastatin 17.09 µM -0.112059383273141 0.490319219022016 no 1637 0.455388160987443 2675 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_169 k015-0017 16.025 µM -0.112122636462322 0.490347602397357 no 1638 0.455363084646303 2658 1840002
SGTC_681 1642-0006 26.6 µM -0.112614972993376 0.490568528452143 no 1639 0.455167906917825 2596 4446530
SGTC_1838 st055369 84.5 µM -0.112787673116346 0.490646024826325 no 1640 0.455099445703638 2594 676036
SGTC_1759 st043059 70 µM -0.11344711962054 0.490941943953597 no 1641 0.454838042376465 2630 669426
SGTC_1171 0368-0077 21.4 µM -0.114373795069521 0.491357787422323 no 1642 0.45447074308249 2605 3239779
SGTC_78 0336-0123 156.75 µM -0.114471729521479 0.491401735838258 no 1643 0.454431927818175 2593 6765896
SGTC_779 1360-0071 233 µM -0.115325631385784 0.49178493154706 no 1644 0.454093511496786 2806 7566
SGTC_1808 st050063 61.5 µM -0.116307234439158 0.492225443593689 no 1645 0.453704526136719 2636 4011993
SGTC_3292 9120825 59.784 µM -0.116824208622981 0.492457448914129 no 1646 0.453499679699688 2622 24824900
SGTC_823 0417-1665 178 µM -0.117177948610857 0.492616200210335 no 1647 0.453359520491029 2697 3429856
SGTC_1719 st032227 49.2 µM -0.117620905924822 0.4928149920701 no 1648 0.453184019699219 2648 3125804
SGTC_3145 9085516 49.47 µM -0.119842005010529 0.493811810231554 no 1649 0.452304153261279 2689 25236195
SGTC_2692 st077426 47.7 µM -0.120078504328667 0.493917952328285 no 1650 0.452210480114784 2675 25238571
SGTC_2441 5730946 39.09 µM -0.120407996559068 0.494065830833188 no 1651 0.452079978576227 2736 1774275
SGTC_1419 3993-2473 62.6 µM -0.120526475274747 0.494119005141259 no 1652 0.452033054137625 2643 704026
SGTC_856 0433-0016 11.3 µM -0.122033545961382 0.494795400751247 no 1653 0.451436225486222 2694 3911780
SGTC_1070 indatraline 8.81 µM -0.12216880402733 0.494856107331961 no 1654 0.451382666067343 2639 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2852 9023854 51.95 µM -0.122169157869194 0.494856266143568 no 1655 0.451382525954385 2744 19798528
SGTC_1016 4226-1401 38 µM -0.12281632348224 0.495146728905252 no 1656 0.451126273925942 2595 2901613
SGTC_1953 st076800 12.1 µM -0.122967516205129 0.495214588041418 no 1657 0.451066410508737 2664 297591
SGTC_1729 st035615 45.989 µM -0.123166976233609 0.495304110982427 no 1658 0.450987437782972 2780 17385451
SGTC_1649 st011737 51.3 µM -0.123895843402062 0.49563124783974 no 1659 0.450698872038096 2666 1761035
SGTC_1731 st035964 63 µM -0.123983257772031 0.49567048216182 no 1660 0.450664265568551 2699 6739575
SGTC_565 1418-0001 44.5 µM -0.124115736591664 0.495729942907775 no 1661 0.450611819251818 2740 2862145
SGTC_2425 5628681 7.85 µM -0.124394584613051 0.495855099157365 no 1662 0.450501430449731 2709 5714958
SGTC_1967 st070177 51.4 µM -0.125760471970626 0.496468160412434 no 1663 0.449960766040102 2749 5729214
SGTC_1695 st026914 34.495 µM -0.127019214332241 0.497033138410714 no 1664 0.449462595443714 2618 3289191
SGTC_2649 anisomycin 9.56 µM -0.127374937881181 0.497192803648058 no 1665 0.449321825663042 2685 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1702 st027038 51 µM -0.127733818952813 0.497353886583715 no 1666 0.449179812825519 2697 5521182
SGTC_2666 tannic acid 100 µM -0.127808671589369 0.497387484071069 no 1667 0.449150193706792 2662 16134267 A thiamine antagonist.
SGTC_1508 1080-0625 72.9 µM -0.128301814125807 0.4976088307695 no 1668 0.44895506475387 2602 767111
SGTC_476 mead acid 10 µM -0.128602568762279 0.497743824653119 no 1669 0.448836066805611 2636 5312531 An omega 9 fatty acid.
SGTC_2868 9035608 32.47 µM -0.128725306438086 0.497798915601361 no 1670 0.448787505179994 2597 6462614
SGTC_3092 9117248 49.47 µM -0.130441921579734 0.498569424222341 no 1671 0.448108400638559 2635 17141857
SGTC_499 genistein 192 µM -0.131447864289772 0.499020947737927 no 1672 0.44771051344031 2683 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3127 9126946 49.47 µM -0.132162231257709 0.499341596500305 no 1673 0.447427987053293 2748 27243249
SGTC_403 arphamenine a 50 µM -0.132368105217381 0.499434004599022 no 1674 0.447346570503807 2632 5487158 An arginine aminopeptidase inhibitor.
SGTC_931 2812-0076 566 µM -0.133079465852064 0.499753304453893 no 1675 0.447065267282355 2637 3450959
SGTC_2015 5119600 184 µM -0.13362907279063 0.5 no 1676 0.446847946800391 2769 2828786
SGTC_2754 granisetron 64.02 µM -0.133629370314629 0.499999866453924 no 1677 0.446847829160525 2751 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.134294912959216 0.499701132231806 no 1678 0.446584687838023 2643 4174840
SGTC_1700 st030840 7.9285 µM -0.134952105913883 0.499406145999587 no 1679 0.446324870881331 2757 5499307
SGTC_1866 st057638 64 µM -0.135532541902788 0.499145613000605 no 1680 0.446095418450239 2667 688802
SGTC_2256 7954252 200 µM -0.136360652850275 0.498773909917487 no 1681 0.445768088776356 2727 2972920
SGTC_1471 k673-0312 37 µM -0.136595193386826 0.498668635023771 no 1682 0.445675388005374 2651 24099884
SGTC_1523 st012844 44.7 µM -0.137553903513593 0.498238313409931 no 1683 0.445296494386631 2781 4274103
SGTC_1775 st081588 35.1725 µM -0.137802320267768 0.49812681067897 no 1684 0.445198325274136 2647 1426443 YGL099W LSG1
SGTC_3132 9126706 49.47 µM -0.138056445692565 0.498012745742671 no 1685 0.445097903691528 2874 850858
SGTC_2175 5807670 165.306 µM -0.138155683150406 0.497968202764581 no 1686 0.44505868943506 2668 241186
SGTC_1184 1269-1718 139 µM -0.138727569889472 0.497711510499824 no 1687 0.444832715564725 2784 5403821
SGTC_771 0250-0039 27.3 µM -0.13999317672259 0.497143444398053 no 1688 0.444332690743 2637 3005115
SGTC_811 0416-0114 265 µM -0.140227406776556 0.497038311121477 no 1689 0.444240159181972 2738 6612453
SGTC_2352 9027995 87.8 µM -0.140483498166007 0.496923365702539 no 1690 0.444138994873818 2714 2997347
SGTC_2233 sulbentine 40.3845 µM -0.140690731417546 0.496830350216158 no 1691 0.444057133760231 2652 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2158 5657123 3.6195 µM -0.14095583527442 0.496711360084006 no 1692 0.44395241612628 2639 2858827
SGTC_1977 st070720 65.3 µM -0.142313514820204 0.496101979314186 no 1693 0.443416185947938 2768 682188
SGTC_1480 1070-0044 41.2 µM -0.142502849432812 0.496016999073288 no 1694 0.44334141440976 2756 3124987
SGTC_1286 0929-0070 131 µM -0.143328083324196 0.495646606334467 no 1695 0.443015538757246 2772 1420408
SGTC_857 0438-0306 1.35 µM -0.143372671412184 0.495626593804226 no 1696 0.442997932514524 2737 4686136
SGTC_612 0302-0167 22.4 µM -0.143798871543787 0.495435302400633 no 1697 0.442829646996158 2734 235821
SGTC_683 panaxydol 45 µM -0.14396122129081 0.495362435237907 no 1698 0.442765545758488 2717 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2607 solasodine 47.35 µM -0.144115158390607 0.495293344052296 no 1699 0.442704767505622 2699 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_114 0364-0001 490.298 µM -0.144130408482357 0.495286499401181 no 1700 0.442698746457819 2703 4003655
SGTC_64 000l-0018 272.079 µM -0.144239335293492 0.495237610160757 no 1701 0.442655740312198 2658 6811119
SGTC_502 l-744,832 89.3 µM -0.144344159400195 0.49519056239037 no 1702 0.442614354621598 2766 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_289 k017-0060 526 µM -0.144362930587388 0.49518213740308 no 1703 0.44260694362005 2680 5512909
SGTC_2566 crystal violet carbinol 226 nM -0.144865839190222 0.49495642001502 no 1704 0.442408399122147 2844 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2513 baicalein 25.65 µM -0.145869445495907 0.494505982441641 no 1705 0.442012226255661 2708 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_58 0957-0393 9 µM -0.146565817876027 0.494193441371877 no 1706 0.441737367817369 2661 6997992
SGTC_2047 4141938 200 µM -0.146572560276697 0.49419041531102 no 1707 0.441734706726214 2672 3807862
SGTC_457 grayanotoxin iii 135 µM -0.146906957869085 0.494040334551561 no 1708 0.441602729963746 2726 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1557 sumaresinolic acid 42.3 µM -0.147044733827887 0.493978499659939 no 1709 0.441548355784481 2661 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_491 tetrandrine 80.3 µM -0.147278088664984 0.493873768576189 no 1710 0.441456263291987 2760 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_928 2764-0428 58.7 µM -0.147813341603379 0.493633545377713 no 1711 0.441245039963348 2790 662578
SGTC_1047 2043-3044 82 µM -0.147977335592731 0.493559944818665 no 1712 0.441180327441039 2670 669592
SGTC_1509 1326-1131 80 µM -0.148855192735955 0.493165966019246 no 1713 0.440833949111722 2649 768313
SGTC_1547 harmine 94.2 µM -0.149284781840584 0.492973170540686 no 1714 0.440664461521531 2693 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_815 1582-0027 36.9 µM -0.150117778977099 0.492599334115807 no 1715 0.440335846668194 2746 3128206
SGTC_769 0302-0231 76 µM -0.153128990006286 0.491248005082786 no 1716 0.43914827737732 2752 571869 YER009W NTF2
SGTC_3289 9119912 71.43 µM -0.153356815125185 0.491145768815509 no 1717 0.439058449255815 2788 17014829
SGTC_1206 3978-0017 132 µM -0.153364619169665 0.491142266769543 no 1718 0.439055372290468 2959 3873677
SGTC_2526 patulin 37.61 µM -0.153937708747921 0.490885096100086 no 1719 0.438829425586147 2816 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1169 aniline yellow 25.8 µM -0.155972249696391 0.489972138825737 no 1720 0.438027447510854 2728 6051 A DNA damaging agent.
SGTC_2259 7964009 200 µM -0.15625483291548 0.489845339621823 no 1721 0.437916078530853 2859 313134
SGTC_3339 9145883 14.936 µM -0.157644190962483 0.489221929611828 no 1722 0.437368589790204 2789 2030670
SGTC_1957 st077035 62.4 µM -0.157740527194383 0.489178704152772 no 1723 0.437330632085175 2696 705593
SGTC_2857 9024691 58.44 µM -0.159179625365521 0.488533005300294 no 1724 0.436763677892733 2798 16478292
SGTC_786 4544-0069 423 µM -0.159577292527093 0.488354584042144 no 1725 0.436607033833675 2822 748821 YLR208W SEC13
SGTC_2683 piperine 63.03 µM -0.160040137179418 0.488146922547582 no 1726 0.436424728394237 2713 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2931 9014674 55.67 µM -0.160732501043192 0.487836290180004 no 1727 0.436152045054626 2729 2996810
SGTC_3196 9111891 49.47 µM -0.162197857196552 0.487178875681456 no 1728 0.435575023583412 2639 18891510
SGTC_821 1114-0266 29.2 µM -0.163291218674372 0.486688374738095 no 1729 0.435144573795549 2769 3123235
SGTC_658 3253-0951 102 µM -0.16395405361288 0.486391025232563 no 1730 0.434883657078897 2743 1184878
SGTC_2294 7971431 200 µM -0.16527942689483 0.485796482129374 no 1731 0.434362025536605 2820 5741572
SGTC_3052 9092717 49.47 µM -0.166889851254575 0.485074111888032 no 1732 0.433728359342047 2865 25237534
SGTC_1887 st057648 70.8 µM -0.166970593869415 0.485037895336109 no 1733 0.433696593387081 2849 688672
SGTC_2239 6685329 187.64 µM -0.168409982423255 0.484392288361396 no 1734 0.433130377713963 2841 805680
SGTC_828 2074-0507 139 µM -0.168580433291158 0.484315838943761 no 1735 0.433063336119578 2833 X828
SGTC_1428 4049-0204 61.7 µM -0.168823869302431 0.484206655746261 no 1736 0.432967591409713 2804 X1428
SGTC_1664 st014217 9.02 µM -0.170566373818676 0.483425162171115 no 1737 0.432282370103235 2711 3982782
SGTC_1227 3909-8010 46.6 µM -0.170638668664717 0.483392740104952 no 1738 0.43225394531194 2714 15982272
SGTC_1255 0566-0045 221 µM -0.171189112126037 0.483145886368616 no 1739 0.432037534194048 2835 2788469
SGTC_2482 5981709 142.65 µM -0.17127739271455 0.483106296356019 no 1740 0.432002827891471 2792 877755
SGTC_2469 5655019 90.81 µM -0.171701898058885 0.482915926465631 no 1741 0.431835946770967 2859 2788239
SGTC_1477 0139-0234 16 µM -0.171917694791431 0.482819153673143 no 1742 0.431751117634566 2692 620880
SGTC_2411 st077133 39.94 µM -0.172729907045087 0.482454930922356 no 1743 0.431431867346869 3025 1403142 YNL221C POP1
SGTC_2928 9011484 9.79 µM -0.173633525110418 0.482049736012497 no 1744 0.431076741488445 2820 2994751
SGTC_3249 9135183 49.47 µM -0.173990771313596 0.481889546936692 no 1745 0.430936357517356 2893 4902779
SGTC_978 1416-0512 87.4 µM -0.174365121981857 0.481721691362264 no 1746 0.430789261514189 2761 6814003
SGTC_893 0958-0369 48.9 µM -0.174555445215775 0.481636353324856 no 1747 0.430714480268466 2865 6819948
SGTC_1230 0170-0365 3.77 µM -0.175341798754222 0.481283773346585 no 1748 0.430405534913214 2795 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3113 9123498 49.47 µM -0.175826195504955 0.481066590016954 no 1749 0.430215244596034 2690 8897275
SGTC_2495 cafestol 54.53 µM -0.176449767536434 0.48078701457008 no 1750 0.429970304556767 2923 16667697 An anti-infammatory.
SGTC_959 1222-0044 107 µM -0.176794438178698 0.480632487232866 no 1751 0.429834928964632 2770 6083612
SGTC_157 1348-1695 65.819 µM -0.176916203365205 0.480577896535671 no 1752 0.42978710546928 2719 5380510
SGTC_2071 5230951 39.92 µM -0.176958259668939 0.480559041617368 no 1753 0.429770588019898 2736 1799272
SGTC_1288 0973-0013 65.5 µM -0.177318906922545 0.480397356005099 no 1754 0.429628950266396 2821 4315430
SGTC_970 1315-0089 19.5 µM -0.180209441893609 0.479101588229341 no 1755 0.428494073112243 2736 6811083 YLR033W RSC58
SGTC_678 1218-2179 85.9 µM -0.181194572512895 0.478660024069374 no 1756 0.42810742729975 2715 6820081 YOR116C RPO31
SGTC_837 0091-0265 12.5 µM -0.18124159775658 0.47863894663983 no 1757 0.428088972471561 2730 759367
SGTC_517 1365-0151 113 µM -0.181377385385092 0.478578084894709 no 1758 0.428035684160078 2892 768657
SGTC_630 4356-0227 183 µM -0.182486431421243 0.478081015159242 no 1759 0.427600500867108 2739 779312
SGTC_1060 3448-7350 82 µM -0.182800215185887 0.477940384759423 no 1760 0.427477389881307 2830 570178
SGTC_1673 st016611 27.3 µM -0.183327194923804 0.477704211197873 no 1761 0.427270648758655 2947 5226799
SGTC_2553 4-methylesculetin 85.09 µM -0.183688278231164 0.477542391027203 no 1762 0.427129002527827 2759 5319502
SGTC_649 1123-0311 367 µM -0.184137881830943 0.47734090549777 no 1763 0.426952644574854 2819 693629 YIL048W NEO1
SGTC_896 0964-0007 44.5 µM -0.186152872877832 0.476437978518551 no 1764 0.426162439951219 2687 6756758
SGTC_3347 9188721 44.724 µM -0.186608786948129 0.476233697891565 no 1765 0.425983688392618 2817 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1945 st075991 56.6 µM -0.186980467989848 0.476067164030924 no 1766 0.425837973573685 2794 1084980
SGTC_2802 7925815 54.55 µM -0.187301203275396 0.475923460072813 no 1767 0.425712239802586 2750 1262923
SGTC_2150 5556613 200 µM -0.18730164904492 0.475923260350019 no 1768 0.425712065058487 2771 743190
SGTC_554 4483-2211 187 µM -0.187687692788522 0.47575029939984 no 1769 0.425560739274372 2848 747107
SGTC_620 0109-0052 432 µM -0.188002671066661 0.475609181619768 no 1770 0.425437278654871 2822 493037
SGTC_3227 9130768 49.47 µM -0.188584863404594 0.475348353635322 no 1771 0.425209098595248 2750 17720899
SGTC_2183 6420625 130.508 µM -0.188672460897268 0.475309109994934 no 1772 0.425174768463145 2732 2897619
SGTC_2634 4'-methoxyflavone 100 µM -0.189541835858833 0.474919643419377 no 1773 0.424834084518783 2797 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2980 9014342 25.29 µM -0.189552585879967 0.474914827724925 no 1774 0.424829872234378 2919 2996599
SGTC_515 4092-1064 102 µM -0.191777921242725 0.47391802263372 no 1775 0.423958083117186 2948 717353
SGTC_1318 1280-3875 124 µM -0.192158671973085 0.473747487326948 no 1776 0.423808958776751 2811 373245
SGTC_1766 st045414 44.774 µM -0.193257663678807 0.473255284536353 no 1777 0.423378590367907 2739 253960
SGTC_2867 9039098 71.43 µM -0.194249035178573 0.472811316357167 no 1778 0.422990444745424 2717 6463460
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.194286925499305 0.472794348514274 no 1779 0.422975611260316 2741 688803
SGTC_2893 9048488 25.97 µM -0.194610958285599 0.472649243886347 no 1780 0.422848761807803 2763 6467338
SGTC_3049 9092223 49.47 µM -0.195129589464961 0.47241700401061 no 1781 0.42264574937192 2855 8623917
SGTC_2061 5245884 80.95 µM -0.195541900602024 0.472232380287452 no 1782 0.422484369395756 2731 573863
SGTC_15 0266-0086 27.098 µM -0.195803941242631 0.472115047436321 no 1783 0.422381812561382 2813 1712902 YIL048W NEO1
SGTC_319 1348-1596 45.5 µM -0.196051751492586 0.47200408869438 no 1784 0.422284830023932 2956 5380505
SGTC_2608 thymoquinone 42.66 µM -0.196661201861747 0.47173121236498 no 1785 0.422046336767317 2720 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1993 st073995 70.8 µM -0.197326687470157 0.471433261883775 no 1786 0.421785948161135 2772 3098394
SGTC_1003 4049-0218 100 µM -0.197680481321715 0.471274868190166 no 1787 0.421647531000001 2917 295161
SGTC_323 4013-0906 34.3 µM -0.197773679514287 0.471233144065375 no 1788 0.421611070051061 2862 2910086
SGTC_1753 st043925 64 µM -0.198156796486595 0.471061628821048 no 1789 0.421461194289226 2849 670181
SGTC_3166 9102297 49.47 µM -0.198541606535165 0.470889361017161 no 1790 0.421310667647465 2806 25237072
SGTC_2955 9076254 12.21 µM -0.199635895254246 0.470399510978401 no 1791 0.420882676242687 2840 16459619
SGTC_660 4031-1742 102 µM -0.199730959287266 0.470356958389444 no 1792 0.420845499795256 2743 6738706
SGTC_55 0767-0285 6.563 µM -0.200333508633001 0.470087252975616 no 1793 0.420609878798395 2874 3116166
SGTC_3022 9087993 49.47 µM -0.200579757476782 0.46997703416784 no 1794 0.420513593791192 2766 17173644
SGTC_1739 st037196 92.5 µM -0.201119253871198 0.469735568398099 no 1795 0.420302663586633 2900 612214
SGTC_674 0498-0004 451 µM -0.201925870299014 0.469374566833775 no 1796 0.419987338534518 2813 4231473
SGTC_1305 1181-0477 144 µM -0.202440101851976 0.469144435380389 no 1797 0.419786340298407 2905 6252086
SGTC_954 1189-0853 2.85 µM -0.202669349579804 0.46904184461846 no 1798 0.419696740734218 2716 2828194
SGTC_616 4092-0450 108 µM -0.203260952018978 0.468777105836823 no 1799 0.419465537094261 2820 787165
SGTC_433 pimozide 108 µM -0.204751430060652 0.468110186717216 no 1800 0.418883168077681 2731 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2402 5553605 200 µM -0.205019486396389 0.467990253501341 no 1801 0.418778450226176 2953 6758546
SGTC_2990 9074105 71.4286 µM -0.205052718498924 0.467975385064395 no 1802 0.418765468302314 2793 6502001
SGTC_1910 st062352 60.4 µM -0.206032984312521 0.467536822692351 no 1803 0.418382573122484 2740 2245730
SGTC_1789 tunicamycin 25 nM -0.207071093575833 0.467072424634863 no 1804 0.417977168404052 2883 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2769 toremifene 3.73 µM -0.208525449796857 0.466421894067987 no 1805 0.417409356650762 2950 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_587 k089-0003 57 µM -0.208915264242766 0.466247546033351 no 1806 0.41725719397053 2751 9659696
SGTC_1225 1216-0074 20.6 µM -0.209524434379663 0.465975102165332 no 1807 0.417019431398563 2804 4241466
SGTC_1755 st041960 45.185 µM -0.209607425886894 0.465937986463459 no 1808 0.41698704168768 2906 2257073
SGTC_1284 0929-0043 16 µM -0.209661128672674 0.465913969506156 no 1809 0.416966083003528 2841 1239883
SGTC_534 k292-0788 63.4 µM -0.209892020400885 0.465810711533763 no 1810 0.416875975156734 2807 4146317
SGTC_345 1362-0200 395 µM -0.210932104605346 0.465345600137297 no 1811 0.41647012591682 2798 1419823
SGTC_1867 st057372 64 µM -0.210933851538931 0.465344818972192 no 1812 0.416469444324029 2778 688837
SGTC_1132 3456-3614 2.5 µM -0.21114384166471 0.465250920005979 no 1813 0.41638751530284 3056 3125502
SGTC_1661 st013063 9.66 µM -0.21151346804407 0.465085642962042 no 1814 0.41624331197953 2791 721395
SGTC_1623 st003709 20.3 µM -0.211600688273668 0.465046643642006 no 1815 0.416209286162439 2768 16192618
SGTC_2585 alliin 100 µM -0.2118843454343 0.464919812586995 no 1816 0.41609863192685 2982 87310 A garlic compound which reacts with lipids.
SGTC_3123 9126162 49.47 µM -0.212809636504255 0.464506113895245 no 1817 0.41573772353329 2762 25239884
SGTC_468 gf-109203x 121 µM -0.213263546135111 0.464303184381585 no 1818 0.415560702724185 2872 2396 A protein kinase C inhibitor.
SGTC_431 k089-0097 107 µM -0.214260678121838 0.463857428965022 no 1819 0.415171890134846 2896 5499420
SGTC_1103 duloxetine 36.1 µM -0.21600149465221 0.463079327717406 no 1820 0.414493291251604 2953 60835 A selective serotonin reuptake inhibitor.
SGTC_122 0236-0016 402.397 µM -0.218062649923842 0.462158225941424 no 1821 0.413690149075875 2831 6808838
SGTC_220 paclitaxel 373.376 µM -0.218353446722298 0.462028289094496 no 1822 0.413576867241462 2891 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1170 0310-0127 64.8 µM -0.21984561920734 0.46136160512856 no 1823 0.412995694833403 2872 774975
SGTC_3120 9124077 49.47 µM -0.220049006644323 0.461270742536532 no 1824 0.412916494083159 2749 18774327 YGL155W CDC43
SGTC_2319 6033012 152.6 µM -0.220201695555887 0.461202530653243 no 1825 0.412857038087241 2807 847246
SGTC_426 0988-0037 14.6 µM -0.220299054039394 0.461159037550348 no 1826 0.412819128417226 2838 5383008
SGTC_3310 9130229 44.1445 µM -0.220861653450427 0.460907715777955 no 1827 0.412600078101148 2963 7761258
SGTC_1433 4060-0023 7.6 µM -0.221616564716872 0.460570509903535 no 1828 0.41230619317385 2915 3840627
SGTC_376 3970-0862 59.1 µM -0.221751561453573 0.460510212165328 no 1829 0.412253644484305 2911 3135186
SGTC_3268 9137683 49.47 µM -0.22256977340097 0.460144768516488 no 1830 0.41193518184483 2781 1953228
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.223082708192973 0.459915690057824 no 1831 0.411735568061636 2823 756377
SGTC_2243 6634756 200 µM -0.223728852315263 0.459627138796445 no 1832 0.411484147028329 3075 885676
SGTC_522 1273-0010 11.6 µM -0.223814157045707 0.459589045494809 no 1833 0.411450956832271 3032 5705015
SGTC_728 3030-5151 22.5 µM -0.224413571007231 0.459321384339506 no 1834 0.41121775591505 2788 3125388
SGTC_1412 3909-8563 178 µM -0.225151704418687 0.458991805012989 no 1835 0.410930629551284 2896 23767530
SGTC_2299 7976368 114.88 µM -0.225942477098927 0.458638753332742 no 1836 0.410623079992604 2948 2979718
SGTC_2997 9067075 71.4286 µM -0.227019113028729 0.458158126448718 no 1837 0.41020444005012 2909 27209819
SGTC_153 4077-0274 519.67 µM -0.227905649785024 0.457762408660383 no 1838 0.409859795204029 3094 3121976
SGTC_1506 4226-2149 212 µM -0.228207224237578 0.457627806308559 no 1839 0.409742572741319 2911 991114
SGTC_1207 2099-0101 141 µM -0.228957891465358 0.457292780582916 no 1840 0.409450822266181 2914 5837381
SGTC_2349 9023730 187.07 µM -0.229385162101941 0.457102101560967 no 1841 0.409284783832953 2949 4126287
SGTC_604 1000-0114 314 µM -0.230096122748085 0.456784841473415 no 1842 0.40900853883555 2967 1572745
SGTC_544 k015-0020 52.4 µM -0.230789234282559 0.456475572912108 no 1843 0.408739272640103 2852 3008304
SGTC_2814 7977482 42.97 µM -0.231102760427961 0.456335685202148 no 1844 0.408617485326642 2982 6456762
SGTC_176 1486-1328 72.834 µM -0.231433227277653 0.456188244822121 no 1845 0.408489127052493 2885 22310231
SGTC_445 e6 berbamine 66 µM -0.232133975393442 0.455875620530383 no 1846 0.408216978482686 2917 6610268 A calcium/calmodulin antagonist.
SGTC_1925 st057770 10.1 µM -0.234091570934925 0.455002425083284 no 1847 0.407456944787647 2809 5989122
SGTC_1763 st044482 94.5 µM -0.235038753322735 0.45458000733229 no 1848 0.407089327398523 2956 88505
SGTC_3151 9099821 49.47 µM -0.235272638040302 0.454475708956692 no 1849 0.406998565398322 2952 17174189
SGTC_1846 st056244 14.8 µM -0.23560405563599 0.454327922219184 no 1850 0.406869963052419 2893 5393182
SGTC_1790 st045711 43.5 µM -0.236793268812253 0.453797676870761 no 1851 0.406408586891234 2988 585119
SGTC_2899 9053889 58.44 µM -0.236873198941684 0.453762040636201 no 1852 0.406377581244297 2895 6470052
SGTC_2703 st077852 53.4 µM -0.236916835216021 0.453742585895372 no 1853 0.406360654571889 2984 6281836
SGTC_803 4488-1585 147 µM -0.237866740061376 0.45331910911949 no 1854 0.405992226383307 2953 747204
SGTC_1010 4112-3296 15.2 µM -0.237890052376513 0.453308716929053 no 1855 0.405983185560681 2975 704384
SGTC_265 mycophenolic acid 32.932 µM -0.239156162994228 0.452744356907867 no 1856 0.405492246630307 3062 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3319 9138450 16.7555 µM -0.240753073057839 0.452032681577945 no 1857 0.404873251077552 2861 2029690
SGTC_825 1988-2224 89.6 µM -0.2413180066568 0.451780951330607 no 1858 0.404654327963932 2825 1180859
SGTC_1825 st052143 62.6 µM -0.241329412615094 0.451775869118983 no 1859 0.404649908233188 3007 674173
SGTC_2912 7964298 10.93 µM -0.242428853775401 0.451286022674088 no 1860 0.404223939496531 2906 2975850
SGTC_2040 5100729 123 µM -0.242667415280453 0.451179743438164 no 1861 0.404131525926869 2836 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_415 dibenzyl ketone 100 µM -0.242709614285593 0.451160944130321 no 1862 0.404115179501281 2921 7593
SGTC_1486 3970-0793 4.53 µM -0.244092441716654 0.450544966799073 no 1863 0.403579613086103 2944 2844330
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.244375887422694 0.450418721214645 no 1864 0.403469857396531 3023 688751
SGTC_1571 st070080 73.4 µM -0.245086313951607 0.45010232215022 no 1865 0.403194799852771 2989 4315245
SGTC_1346 1488-2224 62.4 µM -0.245180133050518 0.450060540779647 no 1866 0.403158479263929 2906 3722427
SGTC_1465 k213-0056 144 µM -0.245299493570743 0.450007385599984 no 1867 0.403112271923088 2823 24048857 YMR208W ERG12
SGTC_510 ag-490 170 µM -0.247189946346537 0.449165624792466 no 1868 0.402380612790869 2902 5328779
SGTC_3173 9105693 49.47 µM -0.247538852576938 0.449010292410032 no 1869 0.40224561342323 3012 17096658
SGTC_1136 pergolide 1.05886 µM -0.24765932557754 0.448956659875812 no 1870 0.402199002520487 2850 47811 A dopamine receptor agonist.
SGTC_2929 9013348 24.6 µM -0.250270111544282 0.447794613051819 no 1871 0.401189234322538 2953 2995952
SGTC_3252 9135871 49.47 µM -0.250602281111085 0.447646798071306 no 1872 0.401060808959887 2989 17682838
SGTC_1107 amlodipine 47 µM -0.250846390632904 0.447538174317972 no 1873 0.400966436706622 2907 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_833 3852-0053 558 µM -0.252136816451443 0.446964026739423 no 1874 0.400467656803145 3010 3123681
SGTC_61 0978-8327 98.565 µM -0.252672497367323 0.446725719461131 no 1875 0.40026065115517 2884 6150059 YHR072W ERG7
SGTC_312 4092-0653 6.84 µM -0.252717987944984 0.446705483045442 no 1876 0.400243073311193 2947 1148278
SGTC_548 1436-0017 110 µM -0.253381325459851 0.446410414133287 no 1877 0.399986778517942 2984 9677137
SGTC_3336 9143619 71.43 µM -0.253625568102083 0.446301776437784 no 1878 0.399892420935631 2914 45595730
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.255259579152709 0.445575081974478 no 1879 0.39926130859066 2950 6708739 YPR165W RHO1
SGTC_392 N-ethylmaleimide 8.33 µM -0.256540213683321 0.445005672467355 no 1880 0.398766866525604 2904 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_164 4100-3994 89.624 µM -0.256901904687626 0.4448448740156 no 1881 0.398627250095349 2934 4615967
SGTC_2466 5983409 37.09 µM -0.257216504867524 0.444705018303741 no 1882 0.398505821753713 2892 2879657
SGTC_2346 9031566 143.75 µM -0.257318621763519 0.444659623651026 no 1883 0.398466409122146 2964 4771086
SGTC_147 4466-0538 29.23 µM -0.258717290427671 0.444037938158652 no 1884 0.397926688916892 3076 6742687 YHR072W ERG7
SGTC_95 0471-0001 561.058 µM -0.259325020149148 0.443767854990819 no 1885 0.397692238125963 2877 4015405
SGTC_3244 9134489 49.47 µM -0.259903729078124 0.443510693322259 no 1886 0.397469017356382 2933 16584271
SGTC_2116 5511452 16.8835 µM -0.260373873205654 0.443301792249077 no 1887 0.39728769713223 2992 870744
SGTC_228 caffeine 993.056 µM -0.261599939457178 0.44275708346342 no 1888 0.39681494534899 2991 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2088 5278280 127.392 µM -0.262402756114877 0.442400471815421 no 1889 0.396505474018892 2954 791502
SGTC_1891 st059073 26.2 µM -0.263226107995569 0.442034786884065 no 1890 0.396188154441856 3075 688754
SGTC_1287 0971-0001 34.6 µM -0.263878760460184 0.441744951765518 no 1891 0.395936671218335 2890 4665869
SGTC_758 0868-0029 16 µM -0.264022226377179 0.441681244451405 no 1892 0.395881396035787 2987 762687
SGTC_1392 3455-1037 33.9 µM -0.264505454934994 0.441466673628269 no 1893 0.395695231010084 3024 981132
SGTC_1328 1441-0025 69.2 µM -0.265039067876792 0.441229750290476 no 1894 0.395489682918552 2849 4562601
SGTC_374 0880-0231 82.3 µM -0.265370243919895 0.441082719199877 no 1895 0.395362128282093 2956 6833587
SGTC_356 1634-0012 32.5 µM -0.266391884256236 0.440629196299506 no 1896 0.394968707455834 2984 735457
SGTC_68 0986-0284 82.829 µM -0.266762034652638 0.440464899653181 no 1897 0.394826193600749 3059 423278 YIL048W NEO1
SGTC_2789 5281112 71.43 µM -0.268492805677618 0.439696808170567 no 1898 0.394160005942301 2924 765948
SGTC_1760 st045453 10.4495 µM -0.270012631157773 0.439022518339077 no 1899 0.393575268075481 3012 3323419 YIL048W NEO1
SGTC_677 0929-0063 136 µM -0.271626769928865 0.438306578978578 no 1900 0.392954506832696 2905 1539583
SGTC_2285 7945142 200 µM -0.272522186934166 0.43790951025846 no 1901 0.392610266962165 2997 2970608
SGTC_2121 5257820 149.641 µM -0.273493834104207 0.437478708337594 no 1902 0.392236815706825 3051 791256
SGTC_1558 st069300 45.6 µM -0.275536481338585 0.436573296377035 no 1903 0.391452051005239 2994 24208000
SGTC_3218 9131285 49.47 µM -0.276640429425899 0.436084104728966 no 1904 0.391028108771123 3063 17156417
SGTC_276 colchicine 750 µM -0.276914709143914 0.435962578506021 no 1905 0.390922798915881 3012 2833 A microtubule depolymerizer.
SGTC_410 α-linolenic acid 100 µM -0.277272959320086 0.435803856260111 no 1906 0.390785260602118 3006 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3261 9137475 49.47 µM -0.277363137156303 0.435763904722164 no 1907 0.39075064195416 2935 17027690
SGTC_234 nsc-17383 10.7 µM -0.278378993058813 0.435313894885349 no 1908 0.390360721773756 3047 408974
SGTC_2657 nystatin 74.44 µM -0.279686618008962 0.43473475885489 no 1909 0.389858973020263 2962 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2968 9090663 33.37 µM -0.279725298068128 0.434717629909739 no 1910 0.389844133885146 2973 25236811
SGTC_1934 st074720 32.6 µM -0.281862548993769 0.433771368340491 no 1911 0.389024453618305 2887 17250992
SGTC_2009 4012297 12.05 µM -0.281931740652419 0.433740740248788 no 1912 0.388997925405997 3014 45595307
SGTC_1405 3909-7894 12 µM -0.283040173831477 0.433250140190376 no 1913 0.388573020663542 2993 7104060
SGTC_3321 9137793 26.8275 µM -0.283349571287868 0.433113217101244 no 1914 0.388454440583628 2904 4904192
SGTC_135 0933-0004 26.348 µM -0.284062089151221 0.432797924622249 no 1915 0.388181399593338 3023 21230617 YGL099W LSG1
SGTC_1672 st016598 6.51 µM -0.284643112722736 0.432540850636538 no 1916 0.387958788876934 2946 4665860 YNL267W PIK1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.284911709266359 0.432422019690644 no 1917 0.387855892462919 3036 6708760
SGTC_106 0092-0003 11.579 µM -0.285207051594672 0.432291363083715 no 1918 0.387742759119103 2962 1072148
SGTC_580 1123-0028 41 µM -0.286525498836021 0.431708185199625 no 1919 0.387237833248569 2885 1677248 YPR107C YTH1
SGTC_706 4262-0057 46.9 µM -0.287299973156422 0.431365687663005 no 1920 0.386941321604983 2923 883298
SGTC_2890 9046729 58.44 µM -0.287642646037934 0.431214163107073 no 1921 0.386810148497863 2931 903329
SGTC_354 2783-3500 4.88 µM -0.287664469114957 0.431204513628456 no 1922 0.38680179519368 2939 6740761
SGTC_2805 7950783 58.44 µM -0.288363485821116 0.430895452168617 no 1923 0.386534257607768 3036 1178958 YDL195W SEC31
SGTC_762 1165-0429 115 µM -0.288722515453988 0.430736728160874 no 1924 0.386396865648404 3060 5967793
SGTC_1701 st028638 40.4 µM -0.288727209454305 0.430734653056502 no 1925 0.386395069462259 3030 3490878
SGTC_2859 9028643 45.46 µM -0.289027565842012 0.430601876717556 no 1926 0.386280141430759 2989 17151580
SGTC_2093 5331342 194.4 µM -0.289318557874646 0.430473247491904 no 1927 0.386168806080389 3061 33839
SGTC_2706 st078239 82.5 µM -0.289716641833504 0.430297291630836 no 1928 0.386016511880551 2921 15434492
SGTC_1409 3909-8004 61.9 µM -0.290078695630635 0.430137273366861 no 1929 0.385878016919278 2951 2119279
SGTC_45 0kpi-0036 14.9 µM -0.290499640297935 0.429951241312396 no 1930 0.385717012960564 3054 2795021
SGTC_2424 5537928 59.2 µM -0.291308878158932 0.429593650894389 no 1931 0.385407548984869 2938 5382802
SGTC_233 rapamycin 362 pM -0.292448718443584 0.429090070119193 no 1932 0.384971781752004 2942 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2689 tacrolimus 100 µM -0.292564857548361 0.429038766394257 no 1933 0.384927389275474 2985 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2919 7978188 46.38 µM -0.293058282820577 0.428820812234843 no 1934 0.384738801495825 3094 2980291
SGTC_2073 5212005 126 µM -0.294426466773521 0.428216576325205 no 1935 0.384216022574658 2869 691789
SGTC_3068 9116768 49.47 µM -0.294536542059635 0.428167970682411 no 1936 0.384173972282301 3034 41904888
SGTC_1168 k815-0004 80.5 µM -0.294693525523288 0.428098653809604 no 1937 0.384114004771462 2903 642433
SGTC_509 pifithrin 175 µM -0.29476335132349 0.428067822573586 no 1938 0.384087332283726 3010 4817 A p53 inhibitor.
SGTC_3137 9097352 49.47 µM -0.29520425276521 0.427873154875141 no 1939 0.383918926726744 3223 44120435
SGTC_25 0118-0223 35.662 µM -0.295209792858411 0.427870708913537 no 1940 0.383916810786661 3072 5333628
SGTC_336 4111-0029 111 µM -0.29601157714804 0.42751674891066 no 1941 0.383610620056198 2965 3131175
SGTC_885 0865-0106 16.8 µM -0.297522215904237 0.426850012914949 no 1942 0.383033924818718 2936 2793380
SGTC_2470 5664817 21.68 µM -0.298321476860232 0.426497335245753 no 1943 0.382728906991451 2906 2859561
SGTC_647 0140-0236 81 µM -0.298382208823125 0.426470539379204 no 1944 0.382705733136843 2978 990837
SGTC_1816 st051957 91.6 µM -0.29861286314796 0.42636877427316 no 1945 0.382617724827379 2953 674121
SGTC_890 0929-0006 47.2 µM -0.298955592069029 0.426217570707989 no 1946 0.38248696460636 2934 1378169
SGTC_1822 st052468 42 µM -0.300002931101283 0.425755577804233 no 1947 0.382087459925224 2991 2873678
SGTC_505 gw-5074 63.9 µM -0.301281964825285 0.425191520057215 no 1948 0.381599746186509 3033 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_166 k072-0058 166.424 µM -0.302331412495143 0.424728824744501 no 1949 0.381199717179312 3039 5846229
SGTC_541 4513-1321 94 µM -0.302338906500775 0.424725521053556 no 1950 0.381196861066213 2950 747515
SGTC_2962 9082311 13.18 µM -0.30380726525226 0.424078305517089 no 1951 0.380637365670764 2901 16459453
SGTC_300 r073-0011 5.04 µM -0.30499592572799 0.423554523777817 no 1952 0.380184627690037 3034 2735780
SGTC_570 0987-0065 62.6 µM -0.306069327671466 0.423081646577862 no 1953 0.379775930465088 2885 3104428
SGTC_2383 9036125 200 µM -0.306779189277017 0.422768984496809 no 1954 0.379505724753424 2944 79580
SGTC_1744 st037937 38.9 µM -0.307786255833606 0.422325500518363 no 1955 0.379122490251951 3141 1016152
SGTC_256 clotrimazole 625 nM -0.308318760170973 0.42209104024204 no 1956 0.3789198961813 3012 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1658 st012944 20 µM -0.309186279309507 0.421709132980331 no 1957 0.378589915222401 3031 24207260
SGTC_2878 9043973 25.97 µM -0.30925987824356 0.421676735963078 no 1958 0.37856192423575 3086 6465167
SGTC_2065 5221596 34.26 µM -0.309321249829477 0.421649721624861 no 1959 0.37853858401469 3083 788581
SGTC_2568 diosmetin 100 µM -0.309792678752534 0.421442221931641 no 1960 0.37835930971281 3126 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_917 harmaline 728.087 nM -0.310818821086638 0.42099064032421 no 1961 0.377969180366542 3053 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3267 9137951 49.47 µM -0.311346403942638 0.420758503676939 no 1962 0.377768646892344 2903 16643986
SGTC_1090 efavirenz 20.7 µM -0.311479972315814 0.420699737911864 no 1963 0.377717882971401 3002 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2178 5812956 200 µM -0.311909437855999 0.420510798943644 no 1964 0.377554674855501 2903 5403383
SGTC_2248 tofa 1.1 µM -0.312678511776212 0.420172498530586 no 1965 0.377262461334543 2899 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3023 9089636 49.47 µM -0.312763718444839 0.420135021425516 no 1966 0.377230090950901 3044 17249241
SGTC_2092 5303694 80.6725 µM -0.314523687503597 0.419361083117597 no 1967 0.376561664297835 2984 1963699
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.315835116687599 0.418784590761164 no 1968 0.376063831050539 2970 688669
SGTC_383 2324-0395 7.37 µM -0.315942906177333 0.418737215218512 no 1969 0.376022922107782 3095 3146421
SGTC_2386 9075165 157.42 µM -0.318185523753601 0.417751810230312 no 1970 0.375172106486762 2952 16452277
SGTC_3087 9117406 49.47 µM -0.318300296760509 0.417701392864132 no 1971 0.375128579613821 3079 42546093
SGTC_2701 st077767 14.721 µM -0.318493336876763 0.417616597455563 no 1972 0.375055374064941 2996 5721188
SGTC_2258 7960471 200 µM -0.319979628701699 0.416963852805589 no 1973 0.37449188664576 3041 2974708
SGTC_391 gliotoxin 8.33 µM -0.320269534392111 0.416836559613138 no 1974 0.374382007921109 3132 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2941 9056145 11.23 µM -0.320608692629705 0.416687651441387 no 1975 0.374253474671101 2990 2119517
SGTC_618 k072-0232 33.2 µM -0.320788475561976 0.416608722195009 no 1976 0.374185346699898 3051 5872756 YGL099W LSG1
SGTC_2824 7998404 51.95 µM -0.32299287302841 0.415641210323821 no 1977 0.373350319770683 2948 837851
SGTC_3263 9137018 49.47 µM -0.323185200423579 0.415556821831468 no 1978 0.373277494187879 3018 43844957
SGTC_533 1222-0222 6.71 µM -0.323198233192337 0.415551103516528 no 1979 0.373272559438519 3149 3982874
SGTC_908 3448-7491 47.7 µM -0.323237246052705 0.415533986169229 no 1980 0.37325778766806 2954 1203031
SGTC_2462 5162487 171.77 µM -0.32501527226101 0.414754027057917 no 1981 0.372584756534615 2948 2259986
SGTC_2744 captopril 92.04 µM -0.325308517848097 0.414625422466741 no 1982 0.372473792429273 3068 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2447 5741742 33.78 µM -0.325920409901734 0.414357103061096 no 1983 0.372242286624618 3068 1776504
SGTC_2707 st078556 66.6 µM -0.327044823294613 0.413864143355802 no 1984 0.37181699176302 3049 17250899
SGTC_2779 methotrexate 400 µM -0.327074595828816 0.413851092470772 no 1985 0.37180573280886 3070 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.327643353123576 0.41360179418939 no 1986 0.371590669315644 3096 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1962 st076595 64.5 µM -0.329560674625149 0.412761648977137 no 1987 0.37086597050991 2980 279619
SGTC_2005 4024620 188 µM -0.329928904226776 0.412600341189186 no 1988 0.370726841405639 2969 236743
SGTC_2992 9074591 71.4286 µM -0.330222350503049 0.412471803780339 no 1989 0.370615979971415 3098 17741321
SGTC_1676 st018489 23.4 µM -0.330485116067596 0.41235671331879 no 1990 0.370516718557484 2997 3696235
SGTC_483 fpl-64176 144 µM -0.330539491042178 0.41233289819776 no 1991 0.370496179130691 3002 3423
SGTC_2453 5731132 22.18 µM -0.33081436923202 0.412212512143641 no 1992 0.370392353184642 3140 1362040
SGTC_231 b-estradiol 524 µM -0.330935495519414 0.412159466118797 no 1993 0.370346604819585 2987 450 A steroid.
SGTC_2682 pyrogallin 40.03 µM -0.330981316466909 0.412139399719487 no 1994 0.370329299116784 3026 822798 An ATP competetive kinase inhibitor.
SGTC_2541 muurolladie-3-one 83.07 µM -0.331559470154033 0.411886228225622 no 1995 0.370110963993395 3150 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1611 st001856 99.4 µM -0.331628148461801 0.411856156667788 no 1996 0.370085030958467 3025 647478
SGTC_1638 st008370 60.6 µM -0.331972896785226 0.411705212619953 no 1997 0.369954862385904 2981 24207134
SGTC_739 1486-1183 203 µM -0.332451838004486 0.4114955354599 no 1998 0.369774050569124 3127 4346692
SGTC_2640 pentamidine 10.38 µM -0.332793130126134 0.411346135543319 no 1999 0.369645222157523 3092 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1148 3909-7663 27.7 µM -0.33313589787113 0.411196102614057 no 2000 0.369515851465102 3119 4084526
SGTC_477 mead ethanolamide 10 µM -0.333203332736675 0.411166587215558 no 2001 0.369490401289382 3002 16061185
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.334114790867697 0.410767702769541 no 2002 0.369146469651621 3042 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_709 3807-1509 243 µM -0.335421536107679 0.41019598856969 no 2003 0.368653562256482 3022 1886677 YPL242C IQG1
SGTC_200 k038-0079 37.545 µM -0.337995036350704 0.40907061532807 no 2004 0.367683464156248 2992 3436683
SGTC_2430 5571206 200 µM -0.337998257320457 0.40906920728849 no 2005 0.367682250517496 3158 1731771
SGTC_3326 9140064 16.379 µM -0.340918725177221 0.407793016432149 no 2006 0.366582383865398 2984 1868434
SGTC_2153 5569715 200 µM -0.342070180297952 0.407290119666528 no 2007 0.366149038972105 3038 2054701
SGTC_968 1309-0633 340 µM -0.343323587368436 0.406742869184952 no 2008 0.36567751892884 3105 3761976
SGTC_2837 9008476 45.46 µM -0.34360093717027 0.406621799957513 no 2009 0.365573209909507 3186 2992805
SGTC_316 k060-0003 58.6 µM -0.344678985448455 0.406151293279161 no 2010 0.365167859134635 3134 6152314
SGTC_2681 menadione 3.18 µM -0.345444814903338 0.40581713461362 no 2011 0.36487999543902 3096 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_659 k018-0002 107 µM -0.345528650025885 0.405780558526261 no 2012 0.364848487707257 3141 6797879 YHR007C ERG11
SGTC_189 3970-0742 2.116 µM -0.346220091151014 0.405478923863106 no 2013 0.364588658397156 3052 2891807
SGTC_2363 9053361 176 µM -0.346785111842972 0.405232480581565 no 2014 0.364376381448846 3180 6469797 YMR079W SEC14
SGTC_1306 1185-0270 9.02 µM -0.347275854354835 0.405018465461055 no 2015 0.364192044384292 3127 1548076
SGTC_266 formosanin C 406 nM -0.348778858234171 0.404363175362048 no 2016 0.36362766830614 3113 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2826 7992541 19.48 µM -0.349564126355358 0.404020915250242 no 2017 0.363332918673274 2990 2985066
SGTC_2288 7946289 167.31 µM -0.351865722290285 0.403018185843484 no 2018 0.362469483482903 3221 1246052
SGTC_1062 mesoridazine 14.2 µM -0.351934263651158 0.402988334376015 no 2019 0.362443781142976 3016 4078 A neuroleptic.
SGTC_2302 7771753 200 µM -0.352138036363782 0.402899589631248 no 2020 0.362367372030773 3099 2203047
SGTC_1587 estradiol valerate 56.1 µM -0.353256922594012 0.402412394440867 no 2021 0.361947918520789 3178 13791 A steroid.
SGTC_2483 5729050 27.16 µM -0.354110168743584 0.402040968369483 no 2022 0.361628160830813 3202 2865180
SGTC_280 3448-3607 3.04 µM -0.354546085508651 0.401851243817605 no 2023 0.361464836404471 3131 626179
SGTC_919 tnp00227 403.569 nM -0.355259423131885 0.401540826976834 no 2024 0.361197625487178 3030 1269246 A methoxyflavone. YNL221C POP1
SGTC_11 0438-0307 1.3 µM -0.355332404613448 0.401509071768949 no 2025 0.361170290988147 3135 4011476
SGTC_1803 st050068 52.4 µM -0.355743504319976 0.401330209005965 no 2026 0.361016330865945 3129 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1734 st037168 69.4 µM -0.356212486269681 0.401126187871887 no 2027 0.360840720875433 3114 708907
SGTC_1118 chelidonine 707.474 nM -0.356949451276416 0.400805640602814 no 2028 0.360564824080668 3138 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_29 0299-0004 12.984 µM -0.357067248865953 0.400754410032095 no 2029 0.360520731047411 3065 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1031 k035-0009 16 µM -0.35707649163492 0.400750390392771 no 2030 0.360517271447952 3199 5180959
SGTC_910 3454-3003 490 µM -0.357188737691769 0.400701575918216 no 2031 0.36047525828336 3166 820824
SGTC_2052 5265182 7.135 µM -0.358593870242061 0.400090631930925 no 2032 0.359949466533516 3177 1239884
SGTC_1747 st037496 66.6 µM -0.360159608839665 0.399410145299586 no 2033 0.359363889058933 3043 723305
SGTC_2842 9000675 19.48 µM -0.363185585289635 0.398095891161321 no 2034 0.35823312740667 3093 2989072
SGTC_3318 9139014 38.6185 µM -0.364473533659778 0.397536853942894 no 2035 0.357752216872471 3033 16643984
SGTC_2916 7875993 68.79 µM -0.364732982219319 0.397424265066676 no 2036 0.357655367961011 3169 1299250
SGTC_2244 6635614 200 µM -0.36498982716265 0.397312814458726 no 2037 0.357559499973831 2943 836499
SGTC_2365 9042475 200 µM -0.365132889247911 0.397250740342674 no 2038 0.357506105606103 3162 6464479
SGTC_698 k064-0052 127 µM -0.365214892422059 0.397215160638342 no 2039 0.357475501216893 3128 5088751
SGTC_1501 4491-0275 38.4 µM -0.366918032566366 0.396476392503203 no 2040 0.356840080068717 3155 5104718
SGTC_382 3229-0966 23.2 µM -0.367696729136689 0.396138742247468 no 2041 0.356549689865432 3216 5722370
SGTC_2129 girgensonine 121.053 µM -0.368151795251951 0.395941457289762 no 2042 0.356380025859668 3097 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1384 3089-0840 101 µM -0.368792521150186 0.395663728378103 no 2043 0.356141189809032 3172 1069836
SGTC_2722 naftopidil 47.16 µM -0.369557912396817 0.395332031492939 no 2044 0.355855957658499 3174 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_204 PMA1.184 62.41 µM -0.370155853860238 0.395072954900789 no 2045 0.355633183780092 3063 2252213 YGL008C PMA1
SGTC_191 3914-0123 66.505 µM -0.371100439493041 0.394663778571983 no 2046 0.355281361848762 3020 3144412
SGTC_1336 1486-0901 104 µM -0.372209576292058 0.394183470165234 no 2047 0.354868408333243 3107 5006114
SGTC_1488 4013-0813 75.9 µM -0.372841411513241 0.393909927670887 no 2048 0.354633239789418 3066 2910057
SGTC_2364 9055074 200 µM -0.373601874539829 0.393580767327586 no 2049 0.354350269546923 3142 6470630
SGTC_799 1310-0557 151 µM -0.373747944529407 0.393517550797832 no 2050 0.354295925727744 3216 5354492
SGTC_2224 6650123 117.647 µM -0.375172546275527 0.392901155563209 no 2051 0.35376607319187 3095 2908370
SGTC_1828 st055811 49 µM -0.375734172012345 0.392658225604469 no 2052 0.353557265326982 3193 5877589
SGTC_2341 7987486 176.74 µM -0.37647736363237 0.392336824014756 no 2053 0.35328102048402 3222 1258686
SGTC_623 k072-0108 16.9 µM -0.377633387255463 0.391837034579399 no 2054 0.352851479342927 3132 5382803
SGTC_822 1487-0950 154 µM -0.378922888915897 0.391279748481022 no 2055 0.352372563281224 3228 1958375
SGTC_1476 4112-3294 3.34 µM -0.379037989877003 0.391230015935024 no 2056 0.352329826580814 3196 704369
SGTC_654 1124-0271 80.9 µM -0.380854850123878 0.390445227415854 no 2057 0.351655478202397 3094 5403748
SGTC_1539 benzyladenosine 56 µM -0.380893649281299 0.390428473065193 no 2058 0.351641082533358 3064 92208 A nucleotide analog.
SGTC_1632 st005650 90 µM -0.380922002677153 0.390416229558487 no 2059 0.351630562694526 3169 2759605
SGTC_834 0312-0008 75.7 µM -0.381912294974088 0.389988671781694 no 2060 0.351263210127445 3076 6385573 YIL048W NEO1
SGTC_469 w7 172 µM -0.382196916279192 0.389865811393391 no 2061 0.351157654493938 3128 45115570 A P450 inhibitor.
SGTC_3085 9117376 49.47 µM -0.382411787952452 0.389773066604387 no 2062 0.351077974053751 3167 16480349
SGTC_641 4092-0595 30 µM -0.383184505583031 0.389439591370769 no 2063 0.350791482823281 3160 786260
SGTC_2395 5646831 180.19 µM -0.383824606176403 0.389163410183389 no 2064 0.350554224641882 3249 6808628
SGTC_207 4185-0010 4.486 µM -0.384485997177878 0.388878101735189 no 2065 0.350309136232875 3165 3761753
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.384490383004825 0.388876209992908 no 2066 0.350307511206452 3314 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1379 2144-0755 36.5 µM -0.384694812566225 0.388788036149297 no 2067 0.350231769480862 3267 5392327
SGTC_1219 1469-0211 33.1 µM -0.385746427833479 0.388334547754469 no 2068 0.349842237263985 3191 6822282
SGTC_3354 9151612 71.43 µM -0.386178830828242 0.38814812658717 no 2069 0.349682115284558 3188 27261949
SGTC_3163 9099914 49.47 µM -0.386231889713854 0.388125253174318 no 2070 0.349662469033728 3161 16268368
SGTC_70 0141-0289 43.283 µM -0.386551103585927 0.387987649908196 no 2071 0.349544281386475 3120 352408
SGTC_1091 telmisartan 47.6 µM -0.38661664812833 0.387959397414905 no 2072 0.349520015588496 3196 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2421 5690543 90.72 µM -0.386812787312433 0.387874856604274 no 2073 0.349447404920062 3185 3397993
SGTC_3264 9137442 49.47 µM -0.390520835011757 0.386277601050639 no 2074 0.348075725906359 3314 17015726
SGTC_3304 9125678 46.087 µM -0.390729440282788 0.386187800494844 no 2075 0.347998617579382 3086 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_124 0136-0217 7.121 µM -0.390848146061485 0.386136702662332 no 2076 0.347954742279815 3266 3976905
SGTC_2381 9035592 200 µM -0.392565705711714 0.385397587097762 no 2077 0.347320136517598 3135 4749657
SGTC_48 0382-0018 55 µM -0.393568130440939 0.38496640684546 no 2078 0.346949957135866 3342 762596
SGTC_3225 9130819 49.47 µM -0.394296670016143 0.384653124012412 no 2079 0.346681010755959 3218 4547121
SGTC_1919 st067113 52.3 µM -0.397527181642132 0.383264866000444 no 2080 0.345489373154929 3216 1268243
SGTC_955 1216-0110 33 µM -0.397627285511087 0.38322187188 no 2081 0.34545247225369 3094 3619719
SGTC_1630 st005209 31.3 µM -0.397668337729016 0.383204240569709 no 2082 0.345437339758361 3226 3367314
SGTC_3122 9126309 49.47 µM -0.398072996752783 0.383030458555017 no 2083 0.345288189279285 3193 17591206
SGTC_897 1000-0139 31.4 µM -0.398546593826597 0.382827100789533 no 2084 0.3451136599127 3249 6151020
SGTC_2839 9003951 25.97 µM -0.401149409254074 0.381710056209947 no 2085 0.344155062668077 3221 2990634
SGTC_1832 st054113 55 µM -0.403217809004034 0.380823067026356 no 2086 0.343393999767749 3235 1251267
SGTC_2653 dihydrofissinolide 100 µM -0.403404881338112 0.380742875838292 no 2087 0.343325198181521 3204 6857746
SGTC_860 0443-0016 25.1 µM -0.405219815732648 0.379965145110291 no 2088 0.342657970249855 3148 5337942
SGTC_1418 3966-3099 2.4 µM -0.407070242926697 0.379172704589012 no 2089 0.341978199055708 3209 740335
SGTC_1482 3346-2049 8.48 µM -0.408010991986848 0.3787700256701 no 2090 0.341632802501634 3212 3826804
SGTC_2419 paclitaxel 166.5 µM -0.408126598718752 0.378720550348168 no 2091 0.34159036656419 3115 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_372 0155-0182 15.9 µM -0.408201227266356 0.378688613199456 no 2092 0.341562973614045 3079 771486
SGTC_2595 hexamethylquercetagetin 100 µM -0.408338718682381 0.378629776171831 no 2093 0.341512508576687 3156 386331
SGTC_3236 9132701 49.47 µM -0.408536749257318 0.378545037422526 no 2094 0.34143982814291 3192 24282524
SGTC_1534 6-azauridine 81.6 µM -0.409191915740606 0.37826472847302 no 2095 0.34119941333277 3136 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2003 4023581 200 µM -0.40993293029671 0.377947767156578 no 2096 0.340927574047811 3242 16641307
SGTC_547 1120-0019 610 nM -0.410058063804666 0.377894250693324 no 2097 0.340881677287027 3119 3676939
SGTC_2045 5106652 78.05 µM -0.410760615929676 0.377593830306513 no 2098 0.340624037319838 3224 673349
SGTC_873 0591-4978 488 µM -0.411334863527961 0.377348329577922 no 2099 0.340413504407843 3313 3305145
SGTC_74 000s-0487 160.283 µM -0.411378040440205 0.377329872706977 no 2100 0.3403976767277 3214 677548
SGTC_2147 5545932 89.7195 µM -0.413818767742547 0.376286989732816 no 2101 0.339503419117806 3180 797404
SGTC_2090 5301565 104.445 µM -0.41462623568933 0.375942170161809 no 2102 0.339207769608147 3133 2056344
SGTC_3025 9087895 49.47 µM -0.41582729178749 0.375429456730147 no 2103 0.338768193305292 3256 17173641
SGTC_1439 4092-1168 46 µM -0.416233834607862 0.375255959275804 no 2104 0.338619451789077 3201 2886240
SGTC_998 3996-0085 177 µM -0.416573616632811 0.375110972217517 no 2105 0.338495155301513 3168 715391
SGTC_1205 4161-2785 76 µM -0.416802754110284 0.375013207821325 no 2106 0.338411343895781 3217 3498106
SGTC_3104 9120930 49.47 µM -0.416928481708205 0.374959567966559 no 2107 0.338365360027754 3231 17014836
SGTC_223 busulfan 5 mM -0.416935454705505 0.374956593109249 no 2108 0.338362809780047 3223 2478 A DNA alkylator.
SGTC_2303 7774051 200 µM -0.420111964329708 0.373602189827988 no 2109 0.337201831419589 3303 2953184
SGTC_38 0929-0051 58.268 µM -0.42048523760331 0.373443135291691 no 2110 0.33706550573079 3251 1379719
SGTC_1836 st055642 81 µM -0.421503022759443 0.373009559018327 no 2111 0.336693902191171 3157 8571
SGTC_1400 3771-8998 51.5 µM -0.424155080495944 0.371880539548166 no 2112 0.335726358923822 3136 670767
SGTC_1812 st052057 4.327 µM -0.424190362781222 0.371865526766233 no 2113 0.335713494299776 3125 3645418
SGTC_2496 diffractaic acid 79.83 µM -0.424280041983733 0.371827368711618 no 2114 0.335680796342766 3363 94870 An apoptosis inducer which activates caspases.
SGTC_185 k048-0037 25.491 µM -0.425182025725679 0.371443649188831 no 2115 0.335351993039717 3267 6827589
SGTC_1269 0831-0796 3.05 µM -0.425553199430875 0.371285782531635 no 2116 0.33521672438711 3274 927758
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.426791242525529 0.370759377883269 no 2117 0.334765692835581 3098 23665772 A membrane-active detergent.
SGTC_3110 9122132 49.47 µM -0.426861468899518 0.37072952550705 no 2118 0.334740115796555 3321 918317
SGTC_2861 9024595 19.48 µM -0.427082713808515 0.370635482079502 no 2119 0.334659541543685 3167 16482810
SGTC_941 3237-0776 460 µM -0.42720956859863 0.370581564056795 no 2120 0.334613346264966 3305 760008
SGTC_952 1185-0122 232 µM -0.42735292929698 0.370520633466303 no 2121 0.334561143228984 3145 678600
SGTC_428 3448-4153 16.5 µM -0.427768070939285 0.370344209951184 no 2122 0.334409992546113 3071 3834874
SGTC_2897 9048598 12.99 µM -0.428833533758263 0.369891543122013 no 2123 0.334022186553676 3158 6467404
SGTC_1470 k295-0292 231 µM -0.430162952944233 0.369326985962564 no 2124 0.333538554470088 3262 5045612
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.43073924483579 0.369082342692084 no 2125 0.333328989948734 3252 616764
SGTC_1 0258-0098 57.368 µM -0.430857329950973 0.369032220594237 no 2126 0.333286055540394 3194 6790032 YDR047W HEM12
SGTC_2539 epi(13)torulosol 80 µM -0.431171631643953 0.368898823777052 no 2127 0.333171789655953 3253 6708597
SGTC_1294 1000-1494 117 µM -0.431213281166835 0.368881147952865 no 2128 0.333156648934294 3186 712797 YDL207W GLE1
SGTC_1687 st020778 55.3625 µM -0.431645331745883 0.368697804473812 no 2129 0.332999602974547 3163 4259299
SGTC_3194 9111903 49.47 µM -0.432819784629736 0.368199568864723 no 2130 0.332572849452316 3335 17087251
SGTC_578 3460-0051 92 µM -0.434257158275315 0.367590096558855 no 2131 0.332050855259025 3302 2876744
SGTC_2103 5378138 10 µM -0.43443231644411 0.367515849095821 no 2132 0.331987267360485 3276 244142
SGTC_80 0159-0065 512.242 µM -0.434566953286137 0.367458781506879 no 2133 0.33193839326094 3262 1548079
SGTC_2091 4-phenylthiadiazole 200 µM -0.435003482651497 0.367273772953361 no 2134 0.331779949768514 3146 270010
SGTC_3098 9119039 49.47 µM -0.436163537658856 0.366782271782103 no 2135 0.331359040360646 3248 17161528
SGTC_1120 ficusin 1.78878 µM -0.437221176658967 0.366334353259193 no 2136 0.330975476676973 3282 6199 A DNA cross-linker.
SGTC_453 enantio-paf c16 10 µM -0.43757891145012 0.366182890900685 no 2137 0.330845780583877 3270 13871343 A lipid and platelet activating factor
SGTC_390 dec-rvkr-cmk 16.7 µM -0.438344993094204 0.365858607547471 no 2138 0.330568107390095 3232 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1854 st056233 32.9 µM -0.438790541667427 0.365670050312147 no 2139 0.330406657165455 3266 5393174
SGTC_602 3130-1533 38.1 µM -0.438887462775253 0.365629037360491 no 2140 0.330371540740877 3278 720941
SGTC_1495 4469-0029 237 µM -0.439069562908723 0.365551984368793 no 2141 0.330305566319105 3202 793680
SGTC_2096 5468907 200 µM -0.43930106038293 0.36545403745185 no 2142 0.33022170297997 3253 759785
SGTC_2128 5255449 168.493 µM -0.439829796444704 0.365230361369943 no 2143 0.330030192612808 3163 736008
SGTC_2254 7938975 95.19 µM -0.439951969716999 0.365178683803114 no 2144 0.329985947285266 3353 2969277
SGTC_2263 7948595 193.29 µM -0.439990677015391 0.365162311673811 no 2145 0.329971929845454 3157 2971371
SGTC_1841 st054148 70 µM -0.440530330905321 0.364934078439222 no 2146 0.329776524754978 3236 675442
SGTC_2969 9091408 28.7 µM -0.440690590472726 0.364866309838824 no 2147 0.329718504772662 3131 4286311
SGTC_2324 6149169 200 µM -0.440839850940501 0.364803196199545 no 2148 0.329664470562807 3202 2888231
SGTC_2600 tangeritin 87.95 µM -0.441893498874734 0.364357773582547 no 2149 0.329283137641131 3172 68077 A bioactive flavone.
SGTC_172 1112-0046 2.638 µM -0.442044459370137 0.36429397102636 no 2150 0.329228517027009 3156 2802135 YIL048W NEO1
SGTC_1113 artemisinin 1.17947 µM -0.443465456770103 0.363693579432389 no 2151 0.32871454968778 3280 2240 An anti-malaria and mitochondrial poison.
SGTC_2946 9065502 71.43 µM -0.44395576929769 0.363486492982988 no 2152 0.328537281299182 3190 16489101
SGTC_44 0929-0055 61.211 µM -0.444974632697504 0.363056297502417 no 2153 0.328169043197017 3139 1379590
SGTC_409 arachidonic acid 100 µM -0.444995864675231 0.363047334543453 no 2154 0.328161371299652 3199 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2911 7942208 15.64 µM -0.446203429440246 0.362537691514678 no 2155 0.327725152952121 3260 1243384
SGTC_344 k064-0035 6.43 µM -0.446213609474556 0.3625333961465 no 2156 0.327721476534421 3168 5088750
SGTC_714 4296-0578 26.1 µM -0.446314950428257 0.362490637243235 no 2157 0.327684879171972 3164 1589775
SGTC_3158 9100007 49.47 µM -0.447733299898694 0.361892371657285 no 2158 0.327172843013137 3185 19297233
SGTC_878 0828-0289 13.7 µM -0.447985077396228 0.36178620609776 no 2159 0.327081983155867 3203 745350 YLR208W SEC13
SGTC_932 2857-0803 154 µM -0.448120100703639 0.361729275982654 no 2160 0.32703326102712 3382 674898
SGTC_2942 9052777 62.25 µM -0.449288507874393 0.361236766344644 no 2161 0.326611773429442 3221 6469503
SGTC_1122 capsaicin 818.572 nM -0.449907358116451 0.360976000268846 no 2162 0.326388620880956 3304 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1077 5-fluorocytosine 377 nM -0.450268013716713 0.360824059937069 no 2163 0.326258599944514 3263 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2455 5377712 9.75 µM -0.450855246982304 0.360576711872367 no 2164 0.326046940055167 3250 2243908
SGTC_1714 st033236 13.627 µM -0.451077680592064 0.360483036010078 no 2165 0.325966781648246 3363 2916566
SGTC_1071 trifluoperazine 6.31 µM -0.451135205072556 0.360458811468392 no 2166 0.325946052858143 3317 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_340 k038-0059 454 µM -0.452631046709509 0.359829083896333 no 2167 0.325407219417231 3274 23733424
SGTC_1369 1866-0067 208 µM -0.452920930198531 0.359707091103662 no 2168 0.325302839478795 3339 3531355
SGTC_909 3448-9333 149 µM -0.453022636697005 0.359664292950025 no 2169 0.325266220708899 3178 3344074
SGTC_1498 4478-3555 97.6 µM -0.453152969632008 0.359609451347967 no 2170 0.325219297641224 3273 3437919
SGTC_245 methotrexate 289.6 µM -0.454572447070212 0.359012349863651 no 2171 0.324708430375386 3261 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1194 1488-0194 225 µM -0.454842404730375 0.358898831417595 no 2172 0.32461131039015 3159 1391452
SGTC_1135 dihydrocapsaicin 536.708 nM -0.455382288838513 0.358671845036874 no 2173 0.324417117424107 3165 107982 A Capsaicinoid.
SGTC_2249 haloperidol 116.36 µM -0.457495828295085 0.357783719080488 no 2174 0.323657350049019 3252 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_306 1672-3436 11.6 µM -0.458251174675814 0.357466502927178 no 2175 0.323385998881593 3296 6797378
SGTC_787 4152-0075 138 µM -0.4592230627834 0.357058492512787 no 2176 0.323036995278621 3225 9566539
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.460347174881152 0.356586780453008 no 2177 0.322633522507338 3177 279621
SGTC_1316 1272-0050 65.9 µM -0.461417753061665 0.356137736708808 no 2178 0.322249458492684 3277 7340392
SGTC_2895 9054447 58.44 µM -0.46187227841794 0.355947150687801 no 2179 0.322086457367918 3213 2697450
SGTC_420 mitomycin C 81.9 mM -0.462521731711439 0.355674892330195 no 2180 0.321853610890946 3196 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_197 4544-0043 41.561 µM -0.464716036757041 0.354755559410966 no 2181 0.321067411261365 3273 896523
SGTC_2100 5377183 190 µM -0.465060602240094 0.354611275824362 no 2182 0.320944029285029 3278 2844202
SGTC_962 1254-0300 21.5 µM -0.465643469051947 0.354367253267564 no 2183 0.320735361403522 3216 7340576
SGTC_2740 felodipine 17.08 µM -0.467072057907094 0.35376941436037 no 2184 0.320224162355958 3272 3333 L-type calcium channel blocker
SGTC_1654 st012436 41.8 µM -0.46709497365001 0.353759827464807 no 2185 0.320215965078356 3303 4323132
SGTC_1460 k062-0059 9.15 µM -0.467872701640952 0.353434516770761 no 2186 0.319937813081689 3173 1373085
SGTC_1813 st051246 8.6015 µM -0.468086892259853 0.353344943183096 no 2187 0.319861226240098 3291 5291959
SGTC_1929 genistein trimethyl ether 50.5 µM -0.47204458361254 0.351691320151934 no 2188 0.318447483062215 3393 136420
SGTC_2597 laccaic acid a 100 µM -0.474158614526589 0.350809170864711 no 2189 0.317693401488167 3313 5491415 A textile dye.
SGTC_1785 bathophenanthroline 24 µM -0.474253700220025 0.350769512067621 no 2190 0.317659501853151 3220 72812 An iron chelator.
SGTC_355 1311-2252 105 µM -0.474996471466062 0.350459769464816 no 2191 0.317394744149623 3239 5338538
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.475482499572331 0.35025714496031 no 2192 0.317221552007043 3221 442882
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.476094623082 0.350002012078457 no 2193 0.317003483742798 3261 6708630 An antioxidant.
SGTC_464 bw-b 70c 158 µM -0.476240443380977 0.349941244205028 no 2194 0.316951544805754 3344 5353454
SGTC_713 1488-1073 324 µM -0.476653637020274 0.349769074386806 no 2195 0.316804391209523 3310 3312542
SGTC_473 2-arachidonoylglycerol 10 µM -0.476807478767114 0.349704979388281 no 2196 0.316749609853925 3195 5282280 An endocannabinoid.
SGTC_736 0958-0254 92.6 µM -0.477179696030484 0.349549920446696 no 2197 0.316617084000547 3361 6812352
SGTC_2207 7258803 200 µM -0.477611412383803 0.349370106705139 no 2198 0.316463403313933 3324 3666799
SGTC_3258 9138477 49.47 µM -0.478492864307977 0.349003079050732 no 2199 0.316149725941919 3291 4970355
SGTC_86 0417-1630 471.922 µM -0.47868836020809 0.348921695659204 no 2200 0.316080173822835 3332 3634867
SGTC_824 1304-0008 100 µM -0.479206636974392 0.348705974796764 no 2201 0.315895816563405 3244 768245
SGTC_1799 st045822 46.1415 µM -0.482654598275647 0.347272087570484 no 2202 0.314670502627055 3354 3674992
SGTC_2289 7946404 165.07 µM -0.483942086238037 0.346737224808533 no 2203 0.314213485415176 3238 1246120 YPR165W RHO1
SGTC_2359 9039622 200 µM -0.485030291438492 0.346285388367568 no 2204 0.313827429194438 3248 6463596
SGTC_2828 7998861 71.43 µM -0.485202890309352 0.346213743229923 no 2205 0.313766216006887 3325 2988188
SGTC_561 1550-0330 72.9 µM -0.486619879712066 0.345625764552217 no 2206 0.313263866439449 3249 6812934
SGTC_1677 st019204 53.9 µM -0.488020255834316 0.34504504519727 no 2207 0.312767746793884 3309 3945625
SGTC_1633 st005664 67.9 µM -0.48905879117735 0.344614612384816 no 2208 0.312400037495821 3219 2063822
SGTC_535 2293-4129 48.2 µM -0.490171245841056 0.344153765941977 no 2209 0.312006363062675 3387 396118 YIL048W NEO1
SGTC_1156 4092-0367 4.88 µM -0.490765325529629 0.343907756686925 no 2210 0.311796218570475 3289 1357585
SGTC_3045 9092950 49.47 µM -0.492301357815281 0.343271989963678 no 2211 0.311253160199123 3409 44120432
SGTC_2930 9013230 14.89 µM -0.493044661482487 0.342964494187825 no 2212 0.310990515341722 3361 2995857
SGTC_3323 9138564 53.9225 µM -0.493731956747145 0.342680260927491 no 2213 0.310747746571256 3406 43912313 YNL103W MET4
SGTC_1355 1499-0035 1.68 µM -0.493845847588681 0.34263316958407 no 2214 0.310707525613953 3274 1548538
SGTC_1104 tacrolimus 29.8 µM -0.495404537664357 0.341988931759356 no 2215 0.310157296147933 3368 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1927 st060202 13.8 µM -0.496063880517224 0.341716550420073 no 2216 0.309924670869558 3399 688887
SGTC_1125 tnp00248 1.32998 µM -0.496683751001345 0.341460550656545 no 2217 0.309706041366155 3404 24207736
SGTC_2232 chlorophetanol 41.5365 µM -0.496704753244089 0.341451878235473 no 2218 0.309698635013446 3372 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_720 r052-1644 49.9 µM -0.496851797397027 0.341391161883693 no 2219 0.309646782674656 3356 1422863 YOR257W CDC31
SGTC_1274 0865-0114 173 µM -0.498003386042557 0.340915798740043 no 2220 0.309240827794963 3308 870624
SGTC_1717 st033143 58.0435 µM -0.49854401833953 0.340692718699596 no 2221 0.309050325833411 3425 674616
SGTC_2053 5265679 138 µM -0.500552630972165 0.339864397312882 no 2222 0.308343003409892 3269 764595
SGTC_2350 9023895 38.85 µM -0.502357489886833 0.339120759649853 no 2223 0.307708038028144 3384 2997209
SGTC_663 1486-0733 13.9 µM -0.503290779368832 0.338736471347038 no 2224 0.307379924127123 3276 722445 YPR165W RHO1
SGTC_177 1327-0068 8.361 µM -0.503781118581251 0.338534638050934 no 2225 0.307207598708988 3367 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_947 3447-0010 211 µM -0.505490475418982 0.337831395941542 no 2226 0.306607193249558 3369 748350
SGTC_1212 0520-0165 585 µM -0.507007989222819 0.337207553395914 no 2227 0.30607460645853 3587 5403258
SGTC_1112 tnp00069 1.16933 µM -0.507625920507488 0.336953652919077 no 2228 0.305857854539332 3362 145826
SGTC_3067 9117431 49.47 µM -0.507735460289899 0.336908652096663 no 2229 0.305819438332723 3294 17150885
SGTC_2083 5306046 65.942 µM -0.507872970994582 0.33685216364407 no 2230 0.305771215593794 3327 539837
SGTC_2077 5212015 200 µM -0.508601485007933 0.336552956510221 no 2231 0.305515793927758 3301 780900
SGTC_2407 paclitaxel 400 µM -0.509248025946718 0.336287503081046 no 2232 0.305289191792756 3425 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_466 geldanamycin 89.2 µM -0.509742369344105 0.336084593168032 no 2233 0.305115982751996 3290 5288382 HSP90 inhibitor.
SGTC_1637 st007924 17.4 µM -0.510275852714022 0.335865671300694 no 2234 0.304929108730135 3326 683336
SGTC_599 1935-0052 86.5 µM -0.510325874459743 0.33584514707821 no 2235 0.304911589208059 3267 9557311
SGTC_400 oxethazaine 37.5 µM -0.511004976050506 0.335566556081259 no 2236 0.304673786208281 3353 4621 A local anesthetic.
SGTC_3328 9140624 29.0385 µM -0.511838091402584 0.33522490674882 no 2237 0.304382164464844 3409 4904392
SGTC_1885 st057546 99.9 µM -0.513408436535537 0.334581300098771 no 2238 0.303832822689316 3460 702008
SGTC_1572 epiandrosterone 68.9 µM -0.515380129934733 0.33377388866778 no 2239 0.303143707352542 3346 441302 A steroid.
SGTC_1740 st038286 13.222 µM -0.515608056533798 0.333680601902713 no 2240 0.303064091117623 3442 716786
SGTC_1771 st048882 4.1505 µM -0.51733859239216 0.332972656560735 no 2241 0.30245990915686 3269 4580403
SGTC_1345 1488-0192 31.4 µM -0.520005196775753 0.331882939974868 no 2242 0.301529976511973 3415 658348
SGTC_50 0929-0078 56.389 µM -0.520239767852352 0.331787149590104 no 2243 0.301448235455138 3259 1377751
SGTC_2752 diclazuril 33.15 µM -0.520246256072426 0.331784500190815 no 2244 0.301445974644796 3382 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3010 9080089 71.4286 µM -0.52181328124861 0.331144867905297 no 2245 0.300900170779001 3389 17027233
SGTC_2765 myclobutanil 7.74 µM -0.522279659702888 0.330954595372349 no 2246 0.300737814586667 3414 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2808 7946468 45.46 µM -0.523769738218696 0.330346967646946 no 2247 0.300219351893068 3345 2970879
SGTC_1600 coumarin 106 71.1 µM -0.524120724940339 0.330203906449709 no 2248 0.300097287275966 3459 100336 A hepatotoxic, DNA x-linker.
SGTC_3256 9138902 49.47 µM -0.526319474780502 0.329308267672736 no 2249 0.299333127064821 3363 17228773
SGTC_93 0109-0045 59.227 µM -0.526335729275306 0.329301650204489 no 2250 0.299327481215914 3442 88733
SGTC_3042 9091578 49.47 µM -0.527371118208221 0.328880236853257 no 2251 0.298967947993697 3390 25236497
SGTC_3088 9117578 49.47 µM -0.52737442937094 0.328878889526402 no 2252 0.298966798524983 3441 678341
SGTC_1410 3909-8106 77.9 µM -0.527545995957727 0.328809081361148 no 2253 0.298907242004822 3404 1039210
SGTC_1249 0481-0015 10.2 µM -0.527864863665224 0.328679354192293 no 2254 0.298796566641639 3300 4227577
SGTC_1990 st072050 59.8 µM -0.528071539543539 0.328595281831112 no 2255 0.298724841738212 3309 17233948
SGTC_2777 climbazole 1.536 µM -0.528181374668666 0.328550606231877 no 2256 0.29868672768488 3398 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2423 st077119 87.2 µM -0.530701310586196 0.327526292805467 no 2257 0.297812888849858 3369 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2485 5633444 17.78 µM -0.53197551028372 0.327008844284709 no 2258 0.29737147859005 3382 5724239
SGTC_195 4234-0266 16.654 µM -0.532896889668588 0.326634882008042 no 2259 0.297052479207733 3337 2303354
SGTC_2025 5147754 141 µM -0.533937717100452 0.326212648539094 no 2260 0.296692312965769 3373 315777 YLR208W SEC13
SGTC_1375 2910-0797 186 µM -0.536781845245432 0.325060005109521 no 2261 0.295709156748294 3344 742508
SGTC_1034 k072-0165 12.7 µM -0.537548589238278 0.324749551514835 no 2262 0.295444365656441 3449 5835461
SGTC_1824 st053723 68.6 µM -0.537960558339466 0.324582796034224 no 2263 0.295302139303912 3373 675225
SGTC_2663 amphotericin b 100 µM -0.538297075863785 0.324446607679881 no 2264 0.295185984899622 3399 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1130 3454-2858 15.9 µM -0.538681842550241 0.324290921696874 no 2265 0.295053202306181 3343 715628 YIL048W NEO1
SGTC_1689 st020265 53.493 µM -0.539364568979195 0.324014749547994 no 2266 0.294817661851471 3443 5758320 YPR016C TIF6
SGTC_438 sphingosine 6.67 µM -0.540641516143561 0.323498467021437 no 2267 0.294377348226933 3267 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3018 9082602 49.47 µM -0.54121023648269 0.323268636937612 no 2268 0.294181341324843 3453 17332089
SGTC_407 eburnamonine 100 µM -0.542038249739661 0.322934142510679 no 2269 0.293896078142396 3359 3195
SGTC_2661 dactinomycin 12.96 µM -0.542586245994894 0.322712845910741 no 2270 0.293707355464595 3381 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_845 0330-0138 4.51 µM -0.54339192543543 0.322387603458994 no 2271 0.293429991992114 3396 9039800
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.543470934103872 0.322355715986747 no 2272 0.293402798975975 3401 688788
SGTC_3238 9133470 49.47 µM -0.543763214325843 0.322237764629284 no 2273 0.293302212812422 3464 3534688
SGTC_3047 9092122 49.47 µM -0.543814515883132 0.32221706343815 no 2274 0.293284559394581 3376 17173831
SGTC_2572 astragaloside iv 100 µM -0.545552772120703 0.321515968968777 no 2275 0.292686697985549 3449 45006101 An anti-inflammatory agent.
SGTC_889 0919-1524 82.7 µM -0.545956902720317 0.321353061070396 no 2276 0.292547781159146 3393 3905452
SGTC_1109 tnp00067 928.257 nM -0.547333983019651 0.320798208460895 no 2277 0.292074650491635 3383 676295
SGTC_1811 st050069 61.5 µM -0.54783535799567 0.320596293944368 no 2278 0.291902478961166 3444 3877702
SGTC_1510 1123-0200 71.5 µM -0.547860797323001 0.320586050392953 no 2279 0.29189374438863 3532 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2669 eugenol 100 µM -0.548186495412604 0.320454914931926 no 2280 0.291781926969813 3407 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1100 amiodarone 5.07 µM -0.549090477573709 0.320091063066763 no 2281 0.291471679901231 3454 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2986 9022445 71.43 µM -0.549104433312557 0.320085447251442 no 2282 0.291466891491926 3450 6459286
SGTC_2300 7976697 71.57 µM -0.550518070853644 0.319516810615007 no 2283 0.290982042890608 3317 2236109
SGTC_876 0720-0963 56.8 µM -0.551977203403536 0.318930318346765 no 2284 0.290481986026316 3487 765861
SGTC_2552 juarezic acid 87.02 µM -0.552636286596246 0.318665551051769 no 2285 0.29025624468163 3472 1549512
SGTC_1948 st076329 66.6 µM -0.553063339120455 0.318494044657502 no 2286 0.290110019610626 3376 24208413
SGTC_1815 st051655 58.2 µM -0.55580734778505 0.317392966230658 no 2287 0.289171280952645 3424 5984156
SGTC_9 0092-0002 10.449 µM -0.556253566837598 0.317214065839365 no 2288 0.289018762360093 3457 759368
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.556888073735584 0.316959749678278 no 2289 0.28880195177885 3520 1377
SGTC_244 nsc-207895 1.295 µM -0.557398911572767 0.316755064015914 no 2290 0.288627454487466 3360 42640
SGTC_1089 terbinafine 2.25 µM -0.557951295354023 0.316533794580844 no 2291 0.288438821406403 3455 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2293 7624732 200 µM -0.558037266408242 0.316499362891711 no 2292 0.288409468448586 3419 894453
SGTC_2328 6201408 200 µM -0.558600929357176 0.316273653438247 no 2293 0.288217052810351 3443 2890418
SGTC_1624 st003710 6.25 µM -0.558863439787752 0.316168558854598 no 2294 0.288127461220299 3461 24207033
SGTC_2924 9010168 62.78 µM -0.559921252556578 0.315745219980673 no 2295 0.287766575925119 3437 2993929
SGTC_1370 2001-0092 44.6 µM -0.560040723439795 0.315697422659303 no 2296 0.287725830449754 3550 790957
SGTC_1686 st019653 115.5 µM -0.560063584905897 0.315688276708089 no 2297 0.287718033870742 3474 97252
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.560693801370627 0.315436196958455 no 2298 0.287503146792911 3348 803109
SGTC_294 k038-0071 157 µM -0.561397303223273 0.315154905282841 no 2299 0.287263361021209 3439 24152826
SGTC_1371 2421-0008 32.7 µM -0.562426363796608 0.314743633610004 no 2300 0.286912780440366 3384 2827552
SGTC_1905 st060207 84.5 µM -0.562547802921631 0.314695114707548 no 2301 0.286871421909227 3393 1948547
SGTC_224 benfluorex 43.875 µM -0.563560413562201 0.314290668255942 no 2302 0.286526667074355 3471 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3038 9091290 49.47 µM -0.564090759557112 0.314078931843305 no 2303 0.286346183201466 3496 25236843
SGTC_1397 3532-0190 20.1 µM -0.564766375153756 0.313809286322735 no 2304 0.286116340327154 3372 5322280
SGTC_1193 1488-0126 41.5 µM -0.567849364911743 0.312580095243803 no 2305 0.285068628344154 3459 1384710
SGTC_435 c-PAF 6.7 µM -0.570664425427702 0.311459545366111 no 2306 0.284113568908077 3423 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1660 st012960 28.1 µM -0.570993749121798 0.31132857007919 no 2307 0.284001940041228 3436 24207266
SGTC_3035 9091303 49.47 µM -0.57141651412796 0.311160467264248 no 2308 0.283858668704174 3496 25237002
SGTC_397 arbidol 50 µM -0.572523441043351 0.310720509763824 no 2309 0.283483704894072 3512 131410 A RNA synthesis inhibitor.
SGTC_508 roscovitine 141 µM -0.57277667003379 0.310619899750929 no 2310 0.283397958708505 3468 160355 A CDKinase inhibitor.
SGTC_567 1080-0542 68.4 µM -0.573524622976252 0.310322814456234 no 2311 0.283144766052736 3461 5950415
SGTC_1058 3448-5425 97.3 µM -0.57355119724421 0.310312261489198 no 2312 0.283135772283979 3442 7279705
SGTC_112 phenothiazine 287.218 µM -0.573952511212585 0.310152913792464 no 2313 0.28299996865311 3490 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2958 9077254 16.72 µM -0.575660055998973 0.309475306412815 no 2314 0.282422489655517 3532 16457351
SGTC_2427 5545055 42.75 µM -0.576101635385483 0.309300179088037 no 2315 0.282273243065893 3464 5372858
SGTC_329 k048-0121 21.3 µM -0.576733831522508 0.309049529878581 no 2316 0.282059637226788 3480 6832902
SGTC_393 acivicin 6.25 µM -0.576879633880416 0.308991735670317 no 2317 0.282010384710699 3398 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2685 mycophenolic acid 18.85 µM -0.578524421792196 0.308340090359232 no 2318 0.281455057060046 3421 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1044 1222-0021 1.78 µM -0.579238622720139 0.308057320266509 no 2319 0.281214086714427 3452 4306703
SGTC_2493 resveratrol 26.09 µM -0.579441132404145 0.307977162314831 no 2320 0.281145778377229 3453 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_99 0109-0120 622.8 µM -0.579577455712842 0.307923207598694 no 2321 0.281099799813147 3541 759414
SGTC_2532 xanthone 78.9 µM -0.579935311932061 0.30778159324501 no 2322 0.280979120826842 3426 7020 An insecticide.
SGTC_1236 0330-0013 258 µM -0.580757051010859 0.307456515017859 no 2323 0.28070210253896 3418 4617066
SGTC_1642 st009582 77.7 µM -0.581134560916727 0.307307223566265 no 2324 0.280574883634837 3507 6739311
SGTC_341 1486-1430 230 µM -0.581254299293922 0.307259878056198 no 2325 0.280534538244095 3424 2054753 YPL210C SRP72
SGTC_1618 st003135 44.5 µM -0.581833984678144 0.307030711259859 no 2326 0.280339255167967 3445 1270615
SGTC_1198 1612-1005 86.7 µM -0.582676625083972 0.306697724969396 no 2327 0.280055505860158 3565 6998509
SGTC_2898 9056270 58.44 µM -0.582851074840336 0.3066288075587 no 2328 0.27999677934186 3439 19154699
SGTC_2884 9058502 51.95 µM -0.583145492154658 0.306512511759149 no 2329 0.279897680657785 3502 6471554
SGTC_1350 1495-0454 146 µM -0.583641077608775 0.306316797890261 no 2330 0.279730908693345 3536 1069057
SGTC_326 k292-0812 17.5 µM -0.583654039798109 0.306311679675268 no 2331 0.279726547368664 3473 3579357
SGTC_1310 1188-0297 994 nM -0.583707119476363 0.306290721171469 no 2332 0.279708688252182 3461 1588352
SGTC_653 0203-0016 55.2 µM -0.584240775599059 0.306080042352411 no 2333 0.279529165789604 3459 295302
SGTC_2592 piperlongumine 83.33 µM -0.586045307608275 0.305368117604234 no 2334 0.27892253415142 3435 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_92 0063-0024 660.874 µM -0.587100041159341 0.304952344053146 no 2335 0.278568259968627 3517 3594437
SGTC_2908 7930301 100 µM -0.588304227862511 0.304477964113572 no 2336 0.278164054145782 3424 2223178
SGTC_3190 9110366 49.47 µM -0.589453103172307 0.304025680033909 no 2337 0.277778681359893 3441 17123768
SGTC_1237 0330-0133 46.1 µM -0.589955540090344 0.303827977092704 no 2338 0.277610228497497 3460 X1237 YHR072W ERG7
SGTC_2055 5235184 200 µM -0.592191672536451 0.302948782143481 no 2339 0.27686112257414 3508 2836034
SGTC_287 k060-0039 29.6 µM -0.592447032825865 0.302848452934821 no 2340 0.276775639721247 3529 5861974
SGTC_940 3232-1287 54.8 µM -0.594032303465118 0.302225944720386 no 2341 0.276245253654574 3491 1585493 YIL048W NEO1
SGTC_1693 xanthone 101.9 µM -0.594979729845207 0.301854181220793 no 2342 0.275928510256742 3490 7020 An insecticide.
SGTC_1733 st037357 54.9 µM -0.595121816764755 0.301798445030825 no 2343 0.275881023173862 3467 1272339 YGL099W LSG1
SGTC_2059 5238311 157 µM -0.595472278789559 0.301660989679484 no 2344 0.275763911901254 3456 703021
SGTC_2398 5228213 48.84 µM -0.595519162772989 0.301642603361964 no 2345 0.275748246884367 3558 80771 YMR134W ERG29
SGTC_2111 5486399 200 µM -0.59582587269001 0.301522334509309 no 2346 0.275645778839224 3519 689674
SGTC_1951 sophoraflavanone G 9.2 µM -0.596748743120899 0.301160583462884 no 2347 0.275337572030805 3473 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2697 mebhydrolin 72.4 µM -0.597191778208676 0.300986990003767 no 2348 0.275189673906523 3536 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_127 0180-0333 59.125 µM -0.597516830233268 0.300859654285516 no 2349 0.275081186876512 3521 771601
SGTC_3100 9120536 49.47 µM -0.598727812682792 0.300385478654791 no 2350 0.274677203583676 3442 16421196
SGTC_3344 9148862 3.898 µM -0.599077664737331 0.300248552512185 no 2351 0.274560547566289 3568 4905352
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.600803904868104 0.299573344971701 no 2352 0.273985301493317 3547 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2858 9025781 8.96 µM -0.600939163822132 0.299520468398833 no 2353 0.273940253461917 3561 4894980 YPL153C RAD53
SGTC_3102 9121669 49.47 µM -0.602537166773982 0.298896084082097 no 2354 0.273408315450493 3466 41905072
SGTC_2203 7227154 166.4 µM -0.603015498396934 0.298709301631644 no 2355 0.273249189493498 3532 896304
SGTC_780 0109-0199 192 µM -0.603774939622498 0.298412858489866 no 2356 0.27299664145308 3578 610414
SGTC_2733 amorolfine 100 µM -0.603956439208021 0.298342031086741 no 2357 0.272936301892544 3510 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2143 5623677 140.463 µM -0.60435055838919 0.29818825853441 no 2358 0.272805299695883 3522 5375313
SGTC_2108 5365811 200 µM -0.604946396516024 0.297955850344365 no 2359 0.27260730690949 3519 780283
SGTC_503 tyrphostin 8 294 µM -0.605412691403676 0.297774028442497 no 2360 0.27245241019124 3517 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3287 9117173 37.0625 µM -0.605921216271696 0.29757579756047 no 2361 0.272283535097825 3462 2789709
SGTC_1277 0873-0036 22 µM -0.606924926771028 0.297184712529994 no 2362 0.27195036742648 3549 5965735
SGTC_2953 9074162 66.49 µM -0.607185108624131 0.297083373819688 no 2363 0.271864036802567 3499 16451992
SGTC_1117 retinoic acid 1.10837 µM -0.607371977946436 0.297010599494116 no 2364 0.271802040334753 3568 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_979 1426-2828 121 µM -0.607823896142302 0.296834638338285 no 2365 0.271652139343817 3567 747872
SGTC_2205 7238770 200 µM -0.612390707176211 0.295059165327915 no 2366 0.270139644323701 3552 279867
SGTC_481 bay k-8644 50 µM -0.612516402058028 0.295010367235737 no 2367 0.270098074721434 3473 2303 A calcium channel antagonist.
SGTC_2922 7999257 32.47 µM -0.612637237466545 0.294963459225554 no 2368 0.270058115253219 3534 2988377
SGTC_2693 st077581 40.7 µM -0.612762469410278 0.2949148481179 no 2369 0.270016705001387 3541 25238761
SGTC_1976 st070609 63.5 µM -0.612779497810881 0.294908238512705 no 2370 0.270011074492079 3507 682556
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.614843587575654 0.294107564429544 no 2371 0.26932901037446 3567 5024745
SGTC_746 1095-0025 46.6 µM -0.616259765971635 0.293558801228594 no 2372 0.268861544320761 3569 6749286
SGTC_2635 hydroquinidine 100 µM -0.616608634581169 0.293423688923257 no 2373 0.268746448929201 3529 442912 An experimental heart treatment.
SGTC_1297 1068-0111 14.1 µM -0.617265306483635 0.293169446559329 no 2374 0.268529873183875 3499 767057
SGTC_460 trequinsin 123 µM -0.617296103607434 0.293157525405732 no 2375 0.268519718195657 3569 5537 A vasodilator.
SGTC_794 k038-0031 316 µM -0.617327609521745 0.293145330121439 no 2376 0.2685093296919 3589 6624242
SGTC_293 4049-0273 38.5 µM -0.617689527352957 0.293005256131082 no 2377 0.268390008344986 3480 1380311
SGTC_1331 1472-0049 76.2 µM -0.621521111310407 0.291524216637733 no 2378 0.267128404256133 3516 24051409
SGTC_3298 9116858 71.43 µM -0.62160569276703 0.291491562405102 no 2379 0.267100588406499 3566 2506942
SGTC_868 0527-0199 213 µM -0.622093874017953 0.291303124368985 no 2380 0.266940071441667 3470 2849450
SGTC_624 k048-0052 28 µM -0.624224757828222 0.290481269350031 no 2381 0.266239994887891 3506 6835531
SGTC_2991 9074669 71.4286 µM -0.624536288375965 0.290361206934084 no 2382 0.266137723152282 3570 17333109
SGTC_2023 5144124 124 µM -0.624821952467143 0.290251133756209 no 2383 0.266043960550282 3529 2830192
SGTC_2151 5563267 85.4165 µM -0.625066769330962 0.290156815544318 no 2384 0.265963618417577 3536 5310824
SGTC_2623 humulene 100 µM -0.625207329978781 0.290102669601334 no 2385 0.26591749585055 3515 6187145 An anti-inflammatory.
SGTC_2617 dihydrotanshinone i 20.83 µM -0.625700840927971 0.289912599737174 no 2386 0.265755590792899 3563 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1679 SEC14.276 6.7 µM -0.625814292198276 0.289868913589001 no 2387 0.265718378148429 3543 1005053 YMR079W SEC14
SGTC_2333 9017922 200 µM -0.626041366371036 0.28978148447897 no 2388 0.26564390449943 3566 3163164
SGTC_754 3474-0146 171 µM -0.626202874673562 0.289719307362936 no 2389 0.26559094096954 3480 24762078
SGTC_1942 st076330 65.2 µM -0.627386582959742 0.289263797118614 no 2390 0.265202930229217 3612 24208414
SGTC_1989 st071868 50.2 µM -0.628462716863845 0.288849975596148 no 2391 0.26485043152941 3558 16414057
SGTC_394 menadione 8.33 µM -0.628990503717616 0.288647119887903 no 2392 0.264677636619275 3544 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1764 st044502 93.5 µM -0.630304187832512 0.288142494912219 no 2393 0.264247791780334 3567 8407
SGTC_1861 st057647 17.4 µM -0.630685169980576 0.287996226286258 no 2394 0.264123198806917 3609 688668
SGTC_802 4112-3352 742 µM -0.6332288945422 0.287020525867339 no 2395 0.263292089678241 3602 704594
SGTC_1281 0884-0031 11.8 µM -0.634804649821357 0.286416897313482 no 2396 0.262777915153635 3579 1548255
SGTC_1393 3470-5649 58.2 µM -0.63616988052778 0.285894402556964 no 2397 0.262332851151241 3504 4108395
SGTC_1703 st026983 48.3 µM -0.63651391169228 0.285762808068091 no 2398 0.262220758227088 3595 1104023
SGTC_2770 toltrazuril 17.5 µM -0.636746888932423 0.285673708898892 no 2399 0.262144863053055 3571 68591 Kills coccidiodes.
SGTC_2764 methyldopa 94.69 µM -0.64100811887662 0.284046392298261 no 2400 0.260758704036941 3618 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_23 0213-0011 39.996 µM -0.641233913247682 0.283960287786324 no 2401 0.26068535949362 3615 627608
SGTC_1983 st071813 46.9 µM -0.641455920175238 0.283875639758956 no 2402 0.260613255574389 3554 11838595
SGTC_3070 9117005 49.47 µM -0.64244776807303 0.28349761010696 no 2403 0.260291246371898 3614 8779016
SGTC_1180 1193-0155 285 µM -0.642521598806322 0.283469480154374 no 2404 0.260267284994293 3581 2921347
SGTC_2132 5317594 122.667 µM -0.643192249129021 0.283214019644127 no 2405 0.260049681011961 3573 794577
SGTC_2297 7971671 152.32 µM -0.643420102133363 0.28312725224586 no 2406 0.259975771557846 3613 909016
SGTC_2514 salinomycin 42.74 µM -0.643570688546723 0.283069915297408 no 2407 0.259926931277032 3629 23682228 A polyether potassium ionophore.
SGTC_1367 1812-0510 76.9 µM -0.644152404259653 0.282848474873922 no 2408 0.259738305605786 3562 1142582 YDR527W RBA50
SGTC_230 MPP+ 141.667 µM -0.646065382646683 0.28212085291326 no 2409 0.259118506559258 3569 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2218 6965428 192.983 µM -0.646092603181201 0.282110505795495 no 2410 0.259109692711723 3562 675684
SGTC_133 0724-0033 378.92 µM -0.646269043747211 0.282043441326047 no 2411 0.259052566062404 3498 280309
SGTC_1348 1493-0373 93.8 µM -0.646982346055577 0.281772395789498 no 2412 0.258821684610109 3570 3010129
SGTC_1344 1488-0097 29.1 µM -0.648733787367521 0.281107404133174 no 2413 0.258255230715882 3585 747966
SGTC_2330 7979373 200 µM -0.648978839810651 0.281014422493054 no 2414 0.258176026743909 3562 1863007
SGTC_1886 st057356 49.9 µM -0.64980963535294 0.280699299666457 no 2415 0.257907597128741 3550 24207747
SGTC_1152 3909-8331 15.9 µM -0.64996999397315 0.280638494926336 no 2416 0.257855802017667 3577 16001939
SGTC_2943 9068529 45.32 µM -0.650048470127609 0.280608740680847 no 2417 0.257830456540983 3623 3270634
SGTC_2197 6588183 93.1375 µM -0.650302964360865 0.280512259657291 no 2418 0.257748271326763 3577 884136
SGTC_167 3672-0051 66.205 µM -0.650912144649535 0.28028137923479 no 2419 0.257551600652173 3569 3237971
SGTC_921 1561-0023 372 µM -0.6519399205331 0.279892059098699 no 2420 0.257219965338083 3603 24050882
SGTC_2712 st079126 47.7 µM -0.652885324715914 0.279534172987009 no 2421 0.256915105271554 3574 3152970
SGTC_2546 rhodinyl acetate 100 µM -0.65323758511792 0.279400880401244 no 2422 0.256801561602488 3594 6708682
SGTC_3048 9093155 49.47 µM -0.653926463702317 0.279140303381933 no 2423 0.25657959170859 3587 25236002
SGTC_2404 5161160 200 µM -0.656057287488133 0.278335041126526 no 2424 0.255893632531004 3585 2831543
SGTC_2571 chrysanthemic acid 100 µM -0.656314181984745 0.278238034347074 no 2425 0.255810997219635 3553 2743 An insecticide.
SGTC_1329 1447-1697 50.6 µM -0.657386540823001 0.277833275504489 no 2426 0.255466201796851 3599 2840515
SGTC_705 1124-0212 310 µM -0.657670045726429 0.277726315437665 no 2427 0.255375087096547 3610 9554485
SGTC_1570 verbenone 133 µM -0.659032193173436 0.277212688249464 no 2428 0.254937548000886 3631 29025 A natural terpanoid with antifungal properties.
SGTC_719 2810-4230 27.3 µM -0.661047532699189 0.276453614233298 no 2429 0.254290915569859 3596 721079
SGTC_1556 plumbagin 1.48 µM -0.661651302273261 0.27622640408904 no 2430 0.254097360405782 3558 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2917 7979103 53.79 µM -0.661771260318561 0.276181272475849 no 2431 0.254058913715425 3621 2980565
SGTC_192 3455-0609 60.9 µM -0.661815266319927 0.276164717079531 no 2432 0.25404481050693 3664 3769639
SGTC_558 k064-0027 21.3 µM -0.662056238648211 0.276074070073016 no 2433 0.253967590073655 3613 5088526
SGTC_3154 9100113 49.47 µM -0.662417274622013 0.27593828584791 no 2434 0.253851917876216 3591 25237525
SGTC_2750 bromebric acid 70.15 µM -0.662893433523879 0.275759254513343 no 2435 0.253699403779642 3635 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2611 pyromycin 23.93 µM -0.663223268299089 0.275635273171758 no 2436 0.253593785641018 3597 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3216 9129716 49.47 µM -0.663458253183144 0.27554696160404 no 2437 0.253518553979589 3582 8056934
SGTC_2444 5485484 36.41 µM -0.665175967552627 0.274901836444802 no 2438 0.252968974931709 3664 6790631
SGTC_2155 5570423 76 µM -0.665207883381765 0.274889856804965 no 2439 0.25295876946615 3581 797402
SGTC_690 glyoxal 20.3 µM -0.665647532502649 0.274724860234888 no 2440 0.252818208488212 3540 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1809 st050081 57.6 µM -0.6667445383164 0.274313376356094 no 2441 0.252467662249453 3682 5036894
SGTC_888 0916-0002 6.97 µM -0.667087924709094 0.274184635621107 no 2442 0.252357986403907 3655 2802138 YIL048W NEO1
SGTC_621 3584-0052 32.1 µM -0.668949110235941 0.273487368781885 no 2443 0.25176397057873 3635 2273927
SGTC_3156 9099931 49.47 µM -0.670591882793226 0.272872657429298 no 2444 0.25124027748021 3644 18111053
SGTC_1076 itraconazole 331 nM -0.671406093286712 0.272568241061316 no 2445 0.250980932134485 3647 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_589 1227-0070 34.1 µM -0.672232349585242 0.272259493468322 no 2446 0.250717894812128 3634 2841384
SGTC_1239 0337-0584 35.4 µM -0.672945157515522 0.271993277887791 no 2447 0.250491090940783 3681 914301 YML130C ERO1
SGTC_3345 9148410 3.559 µM -0.673367494971945 0.271835606718508 no 2448 0.250356761352085 3596 4903596
SGTC_1456 k015-0012 13 µM -0.674020151869803 0.271592039909173 no 2449 0.250149250976752 3694 2989616
SGTC_2975 9084847 53.72 µM -0.674443303779881 0.271434180783238 no 2450 0.250014759814142 3636 27211724
SGTC_1769 st044406 64.4 µM -0.674751568131517 0.271319209873961 no 2451 0.249916807740584 3634 670903
SGTC_2586 curcumin 80 µM -0.676138928847289 0.270802077551951 no 2452 0.249476221265687 3646 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2788 5282734 71.43 µM -0.67737485912946 0.270341804986528 no 2453 0.2490840727181 3679 743706
SGTC_3080 9117754 49.47 µM -0.67805325694776 0.270089329326247 no 2454 0.248868963228443 3694 9550191
SGTC_463 ikarugamyin 104 µM -0.678492412298992 0.269925954165267 no 2455 0.248729766580175 3681 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_21 0849-0113 22.993 µM -0.679274190892943 0.26963523830634 no 2456 0.24848207316383 3610 1560156
SGTC_161 4065-0411 162.148 µM -0.67989541977511 0.269404337117404 no 2457 0.248285340988304 3647 1906281 YLR208W SEC13
SGTC_3000 9075062 71.4286 µM -0.680628117015306 0.269132132325148 no 2458 0.24805341553628 3629 17057871
SGTC_980 1473-0395 201 µM -0.680951165975879 0.269012160062237 no 2459 0.247951195461087 3600 768876
SGTC_693 4161-2696 114 µM -0.682912979963935 0.268284168645731 no 2460 0.247330915743775 3662 805759
SGTC_1473 k844-0725 134 µM -0.683597251028672 0.268030482147036 no 2461 0.247114760512569 3718 54682906
SGTC_997 3996-0078 137 µM -0.683708303845109 0.267989321844525 no 2462 0.247079689434002 3680 735687
SGTC_217 ketoconazole 989 nM -0.6841668399405 0.267819405026804 no 2463 0.246934909459238 3595 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1352 1496-0991 99 µM -0.684371913562495 0.267743429761409 no 2464 0.246870173409958 3643 3000039
SGTC_2934 9036370 36.88 µM -0.684871231932354 0.26755848871449 no 2465 0.246712590454583 3653 6462800
SGTC_2149 5554786 194.827 µM -0.685482859045316 0.267332037764758 no 2466 0.246519636714601 3691 745063 YPR165W RHO1
SGTC_702 1488-0190 94 µM -0.686041721712176 0.267125207083835 no 2467 0.246343399611175 3654 949357
SGTC_2068 5226020 147 µM -0.688749025890351 0.266124400008586 no 2468 0.245490609245294 3694 1810509
SGTC_1875 nocodazole 6 µM -0.691076078755782 0.265265680150906 no 2469 0.244758866094894 3646 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3316 9136639 10.545 µM -0.692059446211063 0.264903225075717 no 2470 0.244449998922688 3679 4903665
SGTC_121 0557-0495 61.343 µM -0.692551080531185 0.264722110172966 no 2471 0.244295659632645 3783 3104427
SGTC_1655 st012546 55.1 µM -0.693648751927323 0.264317962500905 no 2472 0.243951256111628 3630 720985 YLR208W SEC13
SGTC_982 1491-0518 27.5 µM -0.694430315267835 0.264030393100676 no 2473 0.243706193873122 3634 3091256
SGTC_2676 harmalol 100 µM -0.695400319176219 0.26367371049314 no 2474 0.243402230291109 3664 5459187 A monoamine oxidase inhibitor
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.697186405687099 0.263017587662006 no 2475 0.242843072686524 3532 88881 An O-methylated flavonoid and antioxidant.
SGTC_652 0437-0092 114 µM -0.697255325316108 0.262992286615383 no 2476 0.242821510438093 3661 3091274
SGTC_1564 D-Arginine 115 µM -0.698393157573413 0.262574757538 no 2477 0.242465677158413 3641 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1015 4130-4525 82 µM -0.698603423332505 0.262497637389689 no 2478 0.242399951868271 3678 1363237
SGTC_1647 st011722 22.4 µM -0.698830496483742 0.262414365740324 no 2479 0.242328983732214 3672 2854783
SGTC_3037 9091026 49.47 µM -0.699983293881186 0.261991823746573 no 2480 0.241968868804886 3696 25236398 YIL048W NEO1
SGTC_1602 st001878 87.6 µM -0.70113010081975 0.261571823839668 no 2481 0.241610913411144 3689 595405 YLR310C CDC25
SGTC_37 0566-0070 1.56 µM -0.701407188376659 0.261470396768958 no 2482 0.241524468602894 3695 1626686
SGTC_2226 7298446 200 µM -0.701908542969035 0.261286928760071 no 2483 0.241368100446901 3667 3283010
SGTC_3262 9137218 49.47 µM -0.703519030258829 0.260698027390519 no 2484 0.240866175723132 3541 17650664
SGTC_3234 9132280 49.47 µM -0.704868720928297 0.260205017257013 no 2485 0.240445968645073 3693 17612295
SGTC_977 1348-1378 135 µM -0.705725786313994 0.259892201134861 no 2486 0.240179340877929 3680 X977
SGTC_2198 6589944 200 µM -0.707759537599722 0.259150689243599 no 2487 0.239547298733498 3659 5290268
SGTC_2196 6573537 42.6665 µM -0.708193766750987 0.258992509786079 no 2488 0.239412468239981 3721 2903087
SGTC_429 1112-0049 25.5 µM -0.708314679566425 0.258948472983815 no 2489 0.239374931537149 3668 2836170
SGTC_942 3253-1115 227 µM -0.710187476393709 0.258266889798867 no 2490 0.238793942974846 3727 46497897
SGTC_2490 carminic acid 95.39 µM -0.710358221699515 0.258204795263145 no 2491 0.238741011893648 3625 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2409 alverine citrate 63.97 µM -0.710962893424998 0.257984957996887 no 2492 0.238553615157439 3821 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_16 erodoxin 22.806 µM -0.711969210580404 0.257619312009804 no 2493 0.238241921125687 3712 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.712187793199335 0.257539925463654 no 2494 0.23817424742533 3720 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_351 caspofungin 25 nM -0.712363197742817 0.257476229859134 no 2495 0.238119949378376 3736 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1133 3473-0247 50 µM -0.712635258513111 0.257377451147013 no 2496 0.238035743953151 3706 711311
SGTC_2339 9000433 200 µM -0.713673255719341 0.257000760333576 no 2497 0.237714623813562 3692 2988954
SGTC_3343 9148379 18.9835 µM -0.714114307883213 0.256840788675818 no 2498 0.237578249630896 3728 1955036
SGTC_1401 3807-4679 7.6 µM -0.714349267685171 0.25675558883218 no 2499 0.237505617137704 3689 3291456
SGTC_1056 3448-1962 115 µM -0.715139658349705 0.256469089702369 no 2500 0.237261375277265 3718 715507
SGTC_2331 7980721 200 µM -0.71610930202385 0.2561178429576 no 2501 0.236961930233595 3681 2981221
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.716288205470129 0.256053063841158 no 2502 0.236906704038323 3641 1241132 A phosphatase inhibitor.
SGTC_152 4469-0003 551.229 µM -0.716297411539301 0.256049730648463 no 2503 0.236903862383029 3669 697280
SGTC_1880 MG-132 525 µM -0.716853045743131 0.2558485970305 no 2504 0.236732388391478 3649 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3329 9141233 27.5565 µM -0.717235871669909 0.255710066149773 no 2505 0.236614284405615 3700 4909101 YNL103W MET4
SGTC_328 k915-0120 63.5 µM -0.717457276159759 0.255629965737655 no 2506 0.236545994653595 3705 6624543
SGTC_201 4262-0159 12.803 µM -0.71782585777971 0.255496648192041 no 2507 0.236432333812694 3694 1341029
SGTC_3232 9132874 49.47 µM -0.718732831070042 0.255168746816468 no 2508 0.236152775237161 3700 3784940
SGTC_2907 7721985 69.9 µM -0.719398786426581 0.254928121729581 no 2509 0.235947622189349 3675 3267881
SGTC_2014 4013930 200 µM -0.722558937493571 0.253787906668506 no 2510 0.234975451768934 3690 64556
SGTC_1272 0839-0021 27 µM -0.722865818063125 0.25367732379888 no 2511 0.234881162864334 3730 5027250
SGTC_2442 5158906 48.48 µM -0.723198706914219 0.253557397594729 no 2512 0.234778906576058 3716 1893835
SGTC_1050 3232-1156 69.3 µM -0.723813140840379 0.253336120492256 no 2513 0.23459023035177 3696 700529
SGTC_2793 7325131 81.82 µM -0.724644529529697 0.253036872796999 no 2514 0.234335066684273 3708 4176441
SGTC_1640 st009078 66.4 µM -0.724726624354307 0.25300733390973 no 2515 0.234309879083244 3712 690618
SGTC_20 0481-0013 4.944 µM -0.725001980506299 0.252908270094448 no 2516 0.234225407710343 3715 182045
SGTC_3119 9125183 49.47 µM -0.726306502303466 0.252439224945388 no 2517 0.233825447044116 3599 22695334
SGTC_2311 7694451 200 µM -0.727321511641417 0.252074592335257 no 2518 0.233514511624215 3691 2163142
SGTC_3139 9095020 49.47 µM -0.727710618274987 0.251934883128621 no 2519 0.233395374506465 3500 25236292
SGTC_764 1951-2361 146 µM -0.727772857917704 0.2519125397015 no 2520 0.233376321029791 3699 5438930
SGTC_2480 5767542 37.17 µM -0.72810008232145 0.251795086525353 no 2521 0.23327616173185 3716 2867358
SGTC_953 1188-0045 9.7 µM -0.729313264978365 0.251359881960504 no 2522 0.232905029948651 3722 6144426
SGTC_3303 9125618 40.5795 µM -0.729671991534732 0.251231272328957 no 2523 0.232795352679811 3750 22695467
SGTC_2845 9003024 42.97 µM -0.730297760421083 0.251007006757786 no 2524 0.23260409844574 3731 2990173
SGTC_3001 9076041 71.4286 µM -0.730788056149988 0.250831366643602 no 2525 0.232454310031116 3731 16004211
SGTC_1590 st077108 57.8 µM -0.730820464797061 0.250819759089424 no 2526 0.232444410877052 3689 5489485
SGTC_2355 9061122 103.12 µM -0.731660944476599 0.250518830336321 no 2527 0.232187769999269 3745 5302957
SGTC_852 0418-0143 439 µM -0.733112167389726 0.249999679274407 no 2528 0.231745009822933 3756 5369229
SGTC_2123 5259487 200 µM -0.734069547248472 0.249657505208095 no 2529 0.231453176182469 3705 2173474
SGTC_2846 9008642 19.48 µM -0.734076760734274 0.249654928003771 no 2530 0.231450978107263 3753 2992898
SGTC_2049 5262831 67.185 µM -0.734770973502222 0.249406968673744 no 2531 0.231239493811329 3767 763417
SGTC_252 miconazole 1.30953 nM -0.734933491710708 0.249348939237736 no 2532 0.231190000001286 3692 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_734 2023-0417 80 µM -0.735313657733058 0.249213223593591 no 2533 0.231074246124263 3702 3935732
SGTC_601 0986-0029 62.9 µM -0.735769573408358 0.249050517862996 no 2534 0.230935470474524 3718 24747981
SGTC_2464 5717415 7.67 µM -0.736369336480374 0.248836562439835 no 2535 0.230752980171785 3708 5285744
SGTC_229 benomyl 22.8748 µM -0.7388070508362 0.247967956738996 no 2536 0.230012084870098 3750 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2443 5493264 126.67 µM -0.742885572657009 0.246518324702362 no 2537 0.22877548057773 3776 5340055
SGTC_2245 6637752 200 µM -0.744601191092632 0.245909900584109 no 2538 0.228256423838459 3783 681890
SGTC_34 0469-0683 81.75 µM -0.745947580225182 0.245432984302574 no 2539 0.227849540685965 3737 3690923
SGTC_1720 st037298 9.481 µM -0.746374780878547 0.245281765754123 no 2540 0.227720524608668 3769 597396
SGTC_810 3825-7150 143 µM -0.748468279018304 0.244541443468799 no 2541 0.227088875765797 3777 22330411 YGL099W LSG1
SGTC_858 0438-0351 2.77 µM -0.748636155579097 0.244482129571345 no 2542 0.227038266979299 3773 2799119
SGTC_2622 2-methoxyxanthone 59.94 µM -0.749611984189796 0.244137504776834 no 2543 0.226744215462103 3775 71034 A hepatoprotective.
SGTC_3187 9109394 49.47 µM -0.749676008096653 0.244114903178715 no 2544 0.226724930319918 3709 17098090
SGTC_1039 k821-0043 94 µM -0.74985330751308 0.244052319164773 no 2545 0.226671529405657 3716 15992768
SGTC_1197 1601-0112 267 µM -0.75150922636566 0.243468222927291 no 2546 0.226173125119964 3762 7350313
SGTC_855 0428-0020 25 µM -0.751661622697151 0.2434145057784 no 2547 0.226127287474238 3779 6812414
SGTC_1009 4106-0057 9.87 µM -0.751815017712378 0.243360443077637 no 2548 0.226081154747371 3749 2928005
SGTC_2832 7992762 51.95 µM -0.752211106997103 0.243220874966969 no 2549 0.22596205762754 3721 2985177
SGTC_1950 st077106 7.18 µM -0.752333668409231 0.243177697348716 no 2550 0.22592521274185 3782 13831864
SGTC_208 k072-0098 12.366 µM -0.752831353424306 0.243002408622648 no 2551 0.225775631656681 3752 5948901
SGTC_160 3453-0671 289.699 µM -0.754773771019056 0.242318927679665 no 2552 0.225192367077765 3787 5322268
SGTC_1877 wortmannin 25 µM -0.756934020772613 0.241560023064665 no 2553 0.224544696015111 3760 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2549 cedrol 20.94 µM -0.757398620804769 0.241396975961505 no 2554 0.224405541082731 3703 6708665 A sedative which affects the nervous system.
SGTC_3207 9114163 49.47 µM -0.758008830472949 0.241182919357708 no 2555 0.224222848181343 3772 849233
SGTC_2322 7413319 38.22 µM -0.758590862259687 0.240978843502832 no 2556 0.224048670280607 3833 1840400
SGTC_2641 levomentholum 100 µM -0.758638110277516 0.240962281210899 no 2557 0.224034534288174 3738 16666
SGTC_2356 9061756 188.97 µM -0.758882385527494 0.240876662986255 no 2558 0.223961458392194 3780 20104043
SGTC_2471 5466956 24.79 µM -0.75914109638285 0.240786003145234 no 2559 0.2238840787981 3725 724419
SGTC_1023 4482-3888 16 µM -0.759366083039763 0.240707176345325 no 2560 0.223816798357998 3753 3303168
SGTC_615 k087-0205 167 µM -0.759831236954808 0.240544248583203 no 2561 0.223677734289447 3771 9642773
SGTC_3307 9126885 69.2785 µM -0.759963250764687 0.24049801952993 no 2562 0.223638275923346 3766 24824909
SGTC_1334 1486-0610 236 µM -0.761104789535841 0.240098473398572 no 2563 0.223297239980323 3841 3742339
SGTC_2168 5727979 200 µM -0.761848737991935 0.239838281389997 no 2564 0.223075143967356 3714 695210
SGTC_1381 2324-0066 62.1 µM -0.761957370967636 0.239800300459957 no 2565 0.223042723551627 3802 10885928
SGTC_1138 3761-0006 1.03 µM -0.761975783383673 0.239793863322895 no 2566 0.223037228817753 3734 12061087
SGTC_2010 4012422 159 µM -0.762384158040831 0.239651116309595 no 2567 0.222915379236876 3774 952393
SGTC_773 4358-1457 44.6 µM -0.762672860718286 0.239550228524945 no 2568 0.222829259900872 3760 1186886
SGTC_3089 9117425 49.47 µM -0.76276819446413 0.239516919031217 no 2569 0.222800826230648 3704 9401657
SGTC_2625 euphol 100 µM -0.766080472336611 0.238361184891449 no 2570 0.221814210723226 3772 6708538 A triterpene alcohol.
SGTC_2645 abamectin 100 µM -0.767631289445373 0.237821118700991 no 2571 0.221353133891431 3749 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2041 5107442 45.335 µM -0.768252039190803 0.237605133168511 no 2572 0.221168731132145 3781 793005
SGTC_2056 5235370 200 µM -0.768457662435324 0.237533611738951 no 2573 0.221107667134136 3779 5511916
SGTC_504 lovastatin 124 µM -0.768731616997241 0.237438341155677 no 2574 0.221026325754179 3792 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1483 3453-0561 55.9 µM -0.770529030412102 0.236813792334466 no 2575 0.220493070658598 3798 4546991
SGTC_2556 citropten 84.59 µM -0.770607868058237 0.236786419243752 no 2576 0.220469698062602 3821 2775 A potential DNA crosslinker.
SGTC_381 3461-2219 42.7 µM -0.770872700718499 0.23669447986811 no 2577 0.220391194867301 3760 2883159
SGTC_162 k030-0015 37.8 µM -0.771850320797755 0.236355259118321 no 2578 0.22010154197353 3851 1809920 YMR134W ERG29
SGTC_1745 st081495 74 µM -0.772774880676734 0.236034695941279 no 2579 0.219827810967717 3711 13842402 YBL026W LSM2
SGTC_2368 9071271 200 µM -0.774923560231368 0.235290632446682 no 2580 0.219192414696484 3798 27209959
SGTC_2305 7443522 69.23 µM -0.775150299152068 0.235212190919593 no 2581 0.219125426289707 3733 5415886
SGTC_813 k007-0158 173 µM -0.775249655498136 0.235177822617718 no 2582 0.21909607587115 3816 6523916
SGTC_1144 3486-0183 12.5 µM -0.778270260068013 0.234134291661193 no 2583 0.218204852067007 3811 6744069
SGTC_3297 9117502 71.43 µM -0.77893122016065 0.233906291576248 no 2584 0.218010115955609 3800 7453720
SGTC_1268 0828-0275 2.46 µM -0.779569793696365 0.23368613068647 no 2585 0.217822070706208 3866 745337
SGTC_1520 flindersine 88 µM -0.780191411037132 0.233471926172317 no 2586 0.217639108560176 3915 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2755 lomerizine 42.69 µM -0.780336127720491 0.233422073559338 no 2587 0.217596526475609 3808 3949 A calcium channel blocker.
SGTC_1186 1319-0216 26 µM -0.78063207509747 0.233320142748643 no 2588 0.217509460566558 3866 4565136
SGTC_447 ml7 120 µM -0.781395770007978 0.233057223501105 no 2589 0.217284879113481 3823 4216 Selective myosin light chain kinase inhibitor.
SGTC_2188 6126565 140.678 µM -0.78163166412254 0.232976044885052 no 2590 0.217215536290045 3741 874518
SGTC_1266 0828-0227 32.9 µM -0.782967089656599 0.232516779004704 no 2591 0.216823219146413 3843 3913820
SGTC_1388 3346-4487 254 µM -0.783097449693965 0.232471973900772 no 2592 0.216784944341696 3860 3345614
SGTC_1315 1237-0019 3.69 µM -0.784562807298885 0.231968656919367 no 2593 0.216354971869834 3800 825140
SGTC_1243 0416-0003 5.65 µM -0.78648967552638 0.231307746082646 no 2594 0.215790332663986 3826 2141977
SGTC_2353 9059630 146.67 µM -0.78679134073014 0.231204370867724 no 2595 0.215702011688582 3856 4779114
SGTC_136 0097-0015 404.482 µM -0.786997702549663 0.231133669250878 no 2596 0.215641605533469 3816 4861337
SGTC_883 0850-0245 24.6 µM -0.787230772471817 0.231053831681861 no 2597 0.215573393188611 3899 6823229 YPR165W RHO1
SGTC_3006 9075424 71.4286 µM -0.787705255756862 0.230891346090773 no 2598 0.215434565305124 3790 7465181
SGTC_2516 gossypol 71.55 µM -0.791342014575508 0.229648068167011 no 2599 0.214372218609936 3856 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1059 3448-6867 171 µM -0.791635040339394 0.229548056635211 no 2600 0.21428675463363 3762 3934407
SGTC_3186 9110464 49.47 µM -0.79164286616772 0.229545385965514 no 2601 0.21428447242211 3794 17018021
SGTC_198 3454-2873 16.191 µM -0.79251253823171 0.229248707105677 no 2602 0.214030941926378 3808 710957
SGTC_2309 7664088 163.95 µM -0.792714101996297 0.229179976593636 no 2603 0.21397220613297 3808 704922
SGTC_1909 st060837 51.5 µM -0.794888597088979 0.228439238461889 no 2604 0.213339153936304 3847 678937
SGTC_894 0960-0238 55.9 µM -0.795238238841027 0.228320259244767 no 2605 0.213237466108325 3779 6741907 YDL195W SEC31
SGTC_993 3909-8757 62.7 µM -0.796408143636212 0.227922406932523 no 2606 0.212897423195828 3800 4288324 YLR208W SEC13
SGTC_3071 9117417 49.47 µM -0.798087355717108 0.227352035553817 no 2607 0.212409899254467 3762 45595590 YGL055W OLE1
SGTC_1706 st031321 9.9705 µM -0.799058500493662 0.227022537986314 no 2608 0.212128245738296 3861 6103185
SGTC_2602 kawain 100 µM -0.799791831410322 0.226773906295605 no 2609 0.211915708286636 3783 5369129
SGTC_934 2950-0684 338 µM -0.799834487861523 0.226759448597422 no 2610 0.211903349226069 3886 1121253
SGTC_2865 9030313 51.95 µM -0.801950582092693 0.22604288663504 no 2611 0.211290772440793 3775 42562754
SGTC_707 0865-0008 204 µM -0.802402427977841 0.225890046415239 no 2612 0.211160104532832 3830 723043
SGTC_3209 9113616 49.47 µM -0.802721263315463 0.225782233174518 no 2613 0.211067930035218 3799 16649353
SGTC_215 1287-0124 461.5 µM -0.803345194035018 0.225571337049687 no 2614 0.21088762147374 3855 5560863
SGTC_637 1181-0519 7.26 µM -0.803907160342624 0.225381481106457 no 2615 0.210725297229421 3846 6252091 YGR060W ERG25
SGTC_995 3931-2021 34.6 µM -0.803975868972074 0.225358274639512 no 2616 0.210705455737649 3843 730143
SGTC_2761 levamisole 97.89 µM -0.807126693728503 0.224295532378788 no 2617 0.209796747190004 3801 26879 An alkaline phosphatase inhibitor.
SGTC_1844 rapamycin 4 nM -0.808370233998542 0.223876882795516 no 2618 0.209438740991283 3779 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2520 obtusaquinone 4.71 µM -0.811686825108734 0.22276249537125 no 2619 0.208485678037285 3859 5967872
SGTC_2782 7736369 71.43 µM -0.812013282000368 0.222652975747616 no 2620 0.208392005119271 3906 2950836 YOL077C BRX1
SGTC_1200 1643-0193 18.4 µM -0.814059380218502 0.221967250990192 no 2621 0.207805467199628 3825 5403974
SGTC_1853 st056710 91.2 µM -0.816344782944441 0.221202753883993 no 2622 0.207151483967383 3948 269167
SGTC_984 1492-0255 2.91 µM -0.816795449783559 0.221052177929431 no 2623 0.2070226664979 3836 1585198
SGTC_826 1683-5028 118 µM -0.81742163449741 0.220843055679004 no 2624 0.206843758145999 3925 722377
SGTC_2261 9010538 184.68 µM -0.818840305057486 0.220369692087718 no 2625 0.206438765955592 3850 6457250
SGTC_717 1532-0246 73.2 µM -0.822262976389726 0.219230056912279 no 2626 0.205463621688552 3866 9561992
SGTC_3179 9107801 49.47 µM -0.822787524550448 0.219055699780311 no 2627 0.205314416149061 3858 4818259
SGTC_3295 9122362 53.5725 µM -0.823367579440378 0.218862985374784 no 2628 0.205149496913792 3918 4730473
SGTC_2152 5568786 200 µM -0.824000196020987 0.21865291939161 no 2629 0.204969723290904 3834 5399883
SGTC_1814 st052110 31.539 µM -0.824127135838665 0.21861078187689 no 2630 0.204933661492054 3790 674163
SGTC_2141 5621638 7.665 µM -0.824632483114329 0.218443078833544 no 2631 0.204790136914058 3911 2856238
SGTC_182 3448-4371 550.524 µM -0.824689161557103 0.21842427431627 no 2632 0.204774043298064 3825 3491403
SGTC_986 1493-0483 84 µM -0.825370456379905 0.2181983103729 no 2633 0.204580651242094 3790 40079
SGTC_1696 st025591 34.7925 µM -0.82640428130736 0.217855680772993 no 2634 0.204287397806058 3867 2787147
SGTC_2250 alverine citrate 130 µM -0.826591569224418 0.217793643145898 no 2635 0.204234298749952 3783 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1912 st060209 90.8 µM -0.826710437398447 0.217754274299144 no 2636 0.204200602025891 3906 688787
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.828922217741464 0.217022487306629 no 2637 0.203574211185577 3911 5282309
SGTC_606 k015-0008 38.6 µM -0.829541370781411 0.216817889965428 no 2638 0.203399068452859 3921 1970475
SGTC_430 0958-0115 16.4 µM -0.830259813801051 0.216580622376037 no 2639 0.203195951819762 3844 6833180
SGTC_1604 st002052 72.4 µM -0.831015646085827 0.216331169102322 no 2640 0.202982395317288 3925 6254834 YHR062C RPP1
SGTC_1241 0364-0022 50.8 µM -0.832198242787942 0.215941201284228 no 2641 0.202648527790301 3908 4563895
SGTC_1080 nisoldipine 24.4 µM -0.832614496642715 0.215804036240532 no 2642 0.202531090254224 3859 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2429 5902844 64.44 µM -0.833302793401361 0.215577337739145 no 2643 0.202336990642696 3927 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1966 st070145 16.1 µM -0.834435022586392 0.215204725543698 no 2644 0.202017944266799 3836 3748532
SGTC_119 0121-0043 24.815 µM -0.835690196285754 0.214792090019207 no 2645 0.201664605981286 3924 1092378
SGTC_3195 9113082 49.47 µM -0.83573753798947 0.214776535541941 no 2646 0.201651286280181 3791 17018038
SGTC_1653 st012112 65 µM -0.837594565028989 0.214166911682887 no 2647 0.201129223157669 3862 720429
SGTC_77 0828-0286 12.516 µM -0.837907359000062 0.214064327009838 no 2648 0.201041367706567 3836 745345
SGTC_2848 9016370 25.97 µM -0.838266082743759 0.213946714309144 no 2649 0.200940640154731 3851 7894410
SGTC_904 1141-0088 396 µM -0.838443842918555 0.213888447040379 no 2650 0.200890737347726 3911 1378119
SGTC_1765 st044815 90.4 µM -0.839117958399256 0.213667565503646 no 2651 0.200701559759504 3931 645695
SGTC_1029 k015-0030 64.7 µM -0.839303255860817 0.213606873992394 no 2652 0.200649578322252 3972 2208316
SGTC_1928 4'-methoxychalcone 40.3 µM -0.839321167024828 0.213601007981342 no 2653 0.200644554137618 3940 641818
SGTC_1591 genipin 88.4 µM -0.842181777366559 0.212665346502333 no 2654 0.199843106102754 3936 442424 A DNA cross-linking agent.
SGTC_2378 9074213 121.43 µM -0.84310186974594 0.212364907941118 no 2655 0.199585736572638 3857 657714
SGTC_67 0335-0847 266 µM -0.84361770218835 0.21219658128443 no 2656 0.199441534501452 4071 4552207 YOR254C SEC63
SGTC_2656 pseudo-anisatin 100 µM -0.843718547161019 0.212163682627945 no 2657 0.199413350403177 3929 6708809 A neurotoxin.
SGTC_645 0845-0943 5.41 µM -0.843748088765237 0.212154045834831 no 2658 0.199405094585761 3894 1885106
SGTC_2433 5607874 27.82 µM -0.843806973662706 0.212134837703251 no 2659 0.199388638985614 3890 2252428
SGTC_1833 st055984 71 µM -0.845230914487336 0.211670660817462 no 2660 0.198990962488086 3921 676288
SGTC_46 0329-0187a 2.197 µM -0.845392714978139 0.211617954657964 no 2661 0.198945805299969 3965 46494817
SGTC_2229 7354935 190 µM -0.846031199434383 0.211410044715567 no 2662 0.198767669810831 3816 318112
SGTC_1896 st058441 89 µM -0.846719368039081 0.211186090118192 no 2663 0.198575780293926 3919 688759
SGTC_1793 st048256 72.231 µM -0.847171091042004 0.211039158955908 no 2664 0.198449882235414 3780 672022
SGTC_1491 4138-0063 26.5 µM -0.847813103614623 0.210830435769412 no 2665 0.198271032153903 3841 23883227
SGTC_2163 5671233 125 µM -0.849578468203234 0.210257126778866 no 2666 0.197779743583074 3894 701023
SGTC_1718 roemerine 11.9335 µM -0.850675010637592 0.209901481788514 no 2667 0.197474954202278 3735 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1447 4239-0816 81.9 µM -0.85137996357808 0.209673029060679 no 2668 0.197279159119031 3903 1341554
SGTC_971 1315-0384 26.7 µM -0.851816692641457 0.209531572502784 no 2669 0.197157920020234 3936 6769120
SGTC_2036 5160441 105 µM -0.852564950540808 0.209289342276882 no 2670 0.196950303117856 3890 134534 YIL048W NEO1
SGTC_2032 5185112 25.99 µM -0.852924922308184 0.209172868949385 no 2671 0.19685046998643 3805 5718189
SGTC_2584 androsterone 48.74 µM -0.853305970107292 0.209049617799055 no 2672 0.196744825103671 3892 2754130 A steroid.
SGTC_605 1315-0399 119 µM -0.854010678213495 0.208821790390615 no 2673 0.196549536423044 3988 24020461
SGTC_3211 9128781 49.47 µM -0.854344771846393 0.208713831298175 no 2674 0.196456993463494 3965 17194361
SGTC_2075 5212009 200 µM -0.858123289889382 0.207495131681348 no 2675 0.19541219414122 3787 780898
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.859029835830128 0.207203366827478 no 2676 0.195162027738126 3958 61125 An anti-inflammatory.
SGTC_2894 9048625 32.47 µM -0.860063297480191 0.206871051278611 no 2677 0.194877075786114 3915 4092861
SGTC_1503 4585-0012 61.3 µM -0.860347130046833 0.206779838528366 no 2678 0.194798860158339 3965 2922052
SGTC_2686 alizarin 95.37 µM -0.861359540549112 0.206454683142135 no 2679 0.194520026157535 3938 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_749 1000-0129 128 µM -0.862622876347464 0.20604936333879 no 2680 0.194172424212637 3976 708470
SGTC_2794 7785382 27.27 µM -0.863958225267709 0.205621452767786 no 2681 0.193805419730651 3841 2205081
SGTC_2043 5101342 149 µM -0.86470166948167 0.205383445947302 no 2682 0.193601276458167 3933 678451
SGTC_496 calpeptin 138 µM -0.866966847135105 0.204659279631726 no 2683 0.192980087447346 3948 73364 A calpain inhibitor.
SGTC_542 3381-0244 89.3 µM -0.868419385115101 0.204195710674952 no 2684 0.192582393230906 3967 1112843
SGTC_2690 usnic acid 100 µM -0.870131925313801 0.203649967557681 no 2685 0.192114156315131 3923 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.870647019414707 0.203485990429003 no 2686 0.191973457414364 4019 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3226 9131256 49.47 µM -0.871060355508679 0.20335446432877 no 2687 0.191860599521562 3836 17178073
SGTC_2432 5630864 12.22 µM -0.871706430832916 0.203148980809516 no 2688 0.191684275549791 3975 5714970
SGTC_2957 9076800 11.52 µM -0.872229085089735 0.202982841950445 no 2689 0.191541707739639 3904 16459615
SGTC_524 r073-0010 27.8 µM -0.872521359940623 0.202889970391006 no 2690 0.191462010350135 3856 2772106
SGTC_36 0335-0881 14.2 µM -0.873241585508197 0.202661224057303 no 2691 0.191265706271196 3850 23828853
SGTC_1641 st009299 47.1 µM -0.873269136157872 0.202652476929711 no 2692 0.191258199539922 3853 4046054
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.873984592911646 0.20242540371921 no 2693 0.191063322135081 3965 688664
SGTC_1303 1160-0052 261 µM -0.875093460734717 0.202073769634669 no 2694 0.190761527432152 3905 3562476
SGTC_274 sirtinol 40.1 µM -0.875277974877703 0.202015293680064 no 2695 0.190711337594829 4004 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1261 0712-0010 12.7 µM -0.876677498207677 0.201572088608872 no 2696 0.190330916064069 3942 2840123
SGTC_284 0988-0104 32.6 µM -0.878342948014229 0.201045428973841 no 2697 0.189878817659934 3925 4666532
SGTC_634 1611-4317 11.2 µM -0.879145658613837 0.200791885530718 no 2698 0.189661152060972 3932 2843522
SGTC_1784 st039334 36.3 µM -0.879447681869778 0.200696538446271 no 2699 0.18957929421398 4025 3496984
SGTC_2745 rifampicin 24.3 µM -0.880907129427678 0.200236181983089 no 2700 0.189184044175996 3938 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_181 1447-1644 8.07 µM -0.88158393303145 0.200022912007722 no 2701 0.189000923429463 3958 534600
SGTC_2699 st077704 54.6 µM -0.881834335440765 0.199944041442408 no 2702 0.188933200471979 3945 645852
SGTC_2618 avocadyne 43.43 µM -0.883833597373563 0.199314994349027 no 2703 0.188393023462182 3873 3015189
SGTC_806 3966-4455 5.86 µM -0.885255102903712 0.198868458086602 no 2704 0.188009529484836 3938 714982
SGTC_1646 st011709 75.6 µM -0.885385623283949 0.19882748808374 no 2705 0.187974341848553 3875 5757843
SGTC_371 0195-0006 7.36 µM -0.88591342201285 0.198661865351653 no 2706 0.187832091440498 3800 3928593
SGTC_2314 7727897 200 µM -0.886233906938806 0.198561338100706 no 2707 0.187745747948089 3960 900724
SGTC_347 4534-1311 26.2 µM -0.886263693290944 0.19855199650512 no 2708 0.187737724299092 3949 2862016
SGTC_1417 3966-0327 90.4 µM -0.886983872038927 0.198326214749451 no 2709 0.187543791822734 4022 651118
SGTC_1998 st075797 76.8 µM -0.889504616011609 0.197537162628116 no 2710 0.186865971761306 3888 24208315
SGTC_1139 k015-0024 46.9 µM -0.89062475845476 0.197187141637837 no 2711 0.186565256145611 3957 2766652
SGTC_3174 9107204 49.47 µM -0.894165272163935 0.196083275408679 no 2712 0.185616735040706 4013 3938802
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.894410180753203 0.196007056322892 no 2713 0.185551233659251 4005 23847180
SGTC_2449 5812982 45.77 µM -0.894868895363358 0.195864346084114 no 2714 0.185428587952523 3927 776185
SGTC_2114 5491910 81.25 µM -0.894895123513721 0.195856188176847 no 2715 0.185421576899993 4023 2849228
SGTC_2340 7987427 183.45 µM -0.894942447590231 0.195841469192089 no 2716 0.185408927107219 3987 2239331
SGTC_2182 6325192 200 µM -0.897385876031866 0.195082413509656 no 2717 0.1847565232739 3880 736248
SGTC_2648 atorvastatin 78.68 µM -0.898197646311823 0.194830631822416 no 2718 0.184540093996254 3972 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_656 4090-1979 187 µM -0.898989040862099 0.194585360306996 no 2719 0.184329249030078 4019 22330961
SGTC_2860 9025725 38.96 µM -0.900366988734649 0.194158750974214 no 2720 0.183962491184457 3970 40546248
SGTC_715 0868-0130 184 µM -0.902119844638182 0.193616895049215 no 2721 0.183496604109511 4000 2876258
SGTC_3150 9097574 49.47 µM -0.902680886566696 0.193443656582743 no 2722 0.183347641713839 4001 17217476
SGTC_670 4204-0025 119 µM -0.903594297370901 0.193161816072734 no 2723 0.183105283116969 3983 719039
SGTC_1333 1482-0047 286 µM -0.904681003127156 0.192826830669249 no 2724 0.182817203995545 3959 3811116
SGTC_2179 6298986 200 µM -0.905717649652398 0.192507607376357 no 2725 0.18254265909059 3941 738374
SGTC_945 3381-0768 11.3 µM -0.906385979025063 0.192301974469693 no 2726 0.182365795697666 4034 1126236 YIL048W NEO1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.907007895794111 0.192110742603445 no 2727 0.182201310913618 4029 688798
SGTC_569 4130-2812 160 µM -0.908006621519641 0.191803890112009 no 2728 0.181937361640042 3793 743552
SGTC_3182 9108849 49.47 µM -0.908637399439039 0.191610242083949 no 2729 0.18177077910761 4026 17133045
SGTC_3291 9121177 71.43 µM -0.909823861433248 0.19124632435796 no 2730 0.181457704247858 3999 17015612
SGTC_2772 vinpocetine 57.06 µM -0.91023896147722 0.191119102851825 no 2731 0.181348250458889 3981 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3170 9103054 49.47 µM -0.912142508821615 0.190536361015984 no 2732 0.180846851749826 4006 16432970
SGTC_1431 4049-0260 9.09 µM -0.917979615888644 0.188756232300577 no 2733 0.179314768867147 3973 3854841
SGTC_325 2810-4341 181 µM -0.919795432750476 0.188204563982491 no 2734 0.178839835264053 3999 774970
SGTC_348 k064-0012 10.7 µM -0.920295421701543 0.188052835829492 no 2735 0.178709200460447 3893 5066323
SGTC_2798 7813637 45.45 µM -0.920421907543484 0.188014464024739 no 2736 0.178676162348208 4014 956368
SGTC_1054 3429-0080 167 µM -0.921244979174221 0.187764888193881 no 2737 0.178461269917567 4042 1162877
SGTC_2882 9058044 58.44 µM -0.923993316085463 0.18693300733509 no 2738 0.177744897890886 4025 18076804
SGTC_1984 st072354 53.1 µM -0.924441090509129 0.186797689014761 no 2739 0.177628354654358 3873 5762938
SGTC_3188 9110789 49.47 µM -0.924800370954487 0.186689157600978 no 2740 0.177534878816289 3980 849217
SGTC_2246 7293507 91.5585 µM -0.927170580234588 0.185974143582237 no 2741 0.176918987559359 4050 887656
SGTC_1323 1348-1351 11.2 µM -0.928819211507311 0.185477808508115 no 2742 0.176491393246615 3957 6989654
SGTC_838 0109-0203 71.4 µM -0.928868140322083 0.185463090627912 no 2743 0.176478712907893 4009 759422
SGTC_1093 fluphenazine 7.97 µM -0.929322843345699 0.185326349769752 no 2744 0.176360900127263 4009 6602611 An atypical antipsychotic.
SGTC_1143 3454-2408 5.08 µM -0.929676683540369 0.185219984270802 no 2745 0.176269255170587 3947 X1143
SGTC_1065 prochlorperazine maleate 2.48 µM -0.929896658582224 0.185153878181273 no 2746 0.176212296613571 4051 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_79 0052-0007 94.094 µM -0.92995577005215 0.185136116718348 no 2747 0.176196992753836 3971 2801472
SGTC_260 nsc-65238 3.989 µM -0.932708839530849 0.184310063536509 no 2748 0.175485159822973 3996 3246252
SGTC_1007 4101-0031 70 µM -0.934020819724235 0.183917214554039 no 2749 0.175146576783649 3966 1146276
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.934518631957586 0.183768290159719 no 2750 0.175018214774364 3994 688667
SGTC_2107 5363541 170.161 µM -0.935406604767954 0.183502832769124 no 2751 0.174789397206916 3992 244052
SGTC_3021 9087658 49.47 µM -0.935995785045799 0.18332683067888 no 2752 0.174637678937067 3978 25237042
SGTC_259 usnic acid 108.925 µM -0.937276472595601 0.182944622213975 no 2753 0.174308180964624 4101 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_718 1130-0073 349 µM -0.937715575892538 0.182813690758405 no 2754 0.17419529854372 4058 6740020
SGTC_987 1497-1013 404 µM -0.939704717555837 0.182221303078279 no 2755 0.173684522319394 3962 1676435
SGTC_3039 9090270 49.47 µM -0.94036679731014 0.182024395054469 no 2756 0.173514723575633 4027 17173750
SGTC_1359 1582-0056 520 nM -0.941040210851715 0.181824252798904 no 2757 0.173342126551152 4085 3661189
SGTC_2711 st079103 59.1 µM -0.941280120014358 0.181752983727528 no 2758 0.173280663844146 3974 54693780
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.942090666869751 0.181512326375906 no 2759 0.173073111218815 4010 2724 A muscle relaxant with antifungal properties.
SGTC_2823 7987624 58.44 µM -0.942675618087441 0.181338774004562 no 2760 0.172923424147045 4034 2239440
SGTC_2588 indole-3-carbinol 100 µM -0.943072387454306 0.181221113496231 no 2761 0.172821939153013 4082 3712 Induces cell cycle arrest.
SGTC_237 nikkomycin 200 µM -0.943283150467537 0.181158631943404 no 2762 0.172768045988233 4050 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1000 4048-0884 8.67 µM -0.943755987167506 0.181018506681812 no 2763 0.17264717823939 4073 13040088
SGTC_1897 st060201 15 µM -0.947072357781332 0.180037609000971 no 2764 0.171800954565408 4073 611878
SGTC_1478 0453-0656 35.7 µM -0.94749591433743 0.179912572566882 no 2765 0.171693068588666 4027 5258496
SGTC_1365 1672-3266 55.4 µM -0.947716655039261 0.17984743021156 no 2766 0.171636859899919 4068 6415873
SGTC_2255 7941087 197.44 µM -0.947914208853612 0.179789143057385 no 2767 0.171586565414109 4119 935561
SGTC_2351 9026858 72.31 µM -0.949376796598599 0.179357983902589 no 2768 0.171214503644869 3944 1409300
SGTC_2479 5617353 43.85 µM -0.952757186758335 0.17836396220961 no 2769 0.170356555531527 4098 2731746
SGTC_1748 st037455 53.6035 µM -0.953933734812007 0.178018807854217 no 2770 0.170058593004707 4080 580690
SGTC_816 0325-0417 81.3 µM -0.954678287652012 0.177800602158137 no 2771 0.169870206579479 4061 68101
SGTC_804 1595-0054 20.9 µM -0.955880008457858 0.177448770584246 no 2772 0.169566430105004 3972 761523 Stimulates phospholipase C.
SGTC_2799 7812892 81.82 µM -0.955953899927529 0.177427151498775 no 2773 0.16954776286258 4072 20205235
SGTC_3333 9141820 12.094 µM -0.956314410442212 0.177321697574398 no 2774 0.169456705803924 4023 1939433
SGTC_1656 st012921 11 µM -0.956445830634236 0.177283265336997 no 2775 0.169423519748781 3956 6732821
SGTC_2208 7283366 200 µM -0.956589070483369 0.177241382576062 no 2776 0.169387353759956 4004 898663
SGTC_1939 st074455 53.6 µM -0.956653785416769 0.177222462237033 no 2777 0.169371015800957 4071 1644229
SGTC_807 1315-0151 48 µM -0.957488478097374 0.176978542197981 no 2778 0.169160379595924 4078 4011080
SGTC_314 1671-0008 2.74 µM -0.957508944161559 0.176972564119777 no 2779 0.169155217061199 3926 3913060
SGTC_2854 9024559 71.43 µM -0.959001418582013 0.176536960623843 no 2780 0.168779015273333 4091 3163529
SGTC_2856 9022925 19.48 µM -0.960306485433998 0.176156611393589 no 2781 0.168450493487976 4099 4944862
SGTC_1913 st060213 96.1 µM -0.960657715159099 0.176054337502358 no 2782 0.168362149422071 4097 688959
SGTC_2950 9072895 21.46 µM -0.960862143823925 0.175994827633717 no 2783 0.168310743636135 4004 17332245
SGTC_281 1672-3440 14.9 µM -0.961584818922156 0.175784556606339 no 2784 0.168129100146896 4087 6833000
SGTC_3029 9088683 49.47 µM -0.964265752784995 0.175005897565801 no 2785 0.167456353126218 4092 25236615
SGTC_550 4123-0385 25.7 µM -0.964965002367995 0.174803165648362 no 2786 0.16728117071379 4078 5731123
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.965735234133101 0.174580026628932 no 2787 0.167088341961169 4107 165506
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.9657572593311 0.174573648508105 no 2788 0.167082830026276 4070 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1834 st055981 52.8 µM -0.967418615059862 0.174092974874989 no 2789 0.166667403988298 4077 471719 YDL150W RPC53
SGTC_2605 digitonin 300 nM -0.967917741082421 0.173948729172446 no 2790 0.166542726634741 4100 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2818 7996756 12.99 µM -0.970647877902994 0.17316107425639 no 2791 0.165861827712278 4062 2241621
SGTC_2326 6164455 177.58 µM -0.97197538623526 0.172778905098011 no 2792 0.165531396882056 4040 2888790
SGTC_47 0149-0135 24.25 µM -0.972956699288281 0.172496746072933 no 2793 0.165287411604073 4082 5239155
SGTC_1794 st048918 76.9 µM -0.97596545055256 0.171633466437857 no 2794 0.164540792866175 3957 672303
SGTC_1754 st042065 16.137 µM -0.976281669034887 0.171542896678839 no 2795 0.164462450679611 3885 1126236 YIL048W NEO1
SGTC_1229 0139-0193 12.2 µM -0.977211046238732 0.171276885797382 no 2796 0.164232340225228 4131 3090752
SGTC_1404 3909-7820 48.3 µM -0.978735296384358 0.170841178775033 no 2797 0.163855393614617 4037 23741373
SGTC_3072 9116419 49.47 µM -0.97929002568521 0.170682785550452 no 2798 0.163718348685808 4104 17170162
SGTC_1258 0671-0043 57.1 µM -0.982651811875436 0.169724898349147 no 2799 0.162889417458368 4098 4298767
SGTC_2544 sphondin 68.51 µM -0.984324808046135 0.169249492203618 no 2800 0.162477917776439 4080 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1264 0783-0040 158 µM -0.986151744267946 0.168731319234233 no 2801 0.162029327530107 3958 2855798
SGTC_2921 7974240 10.71 µM -0.986560737419502 0.168615456534078 no 2802 0.161929012998969 4163 2979074 YDR527W RBA50
SGTC_2135 5326629 150.42 µM -0.987359001227193 0.168389465627922 no 2803 0.161733337884795 4034 5020077
SGTC_1435 4092-0789 56.7 µM -0.988250619556646 0.168137276173364 no 2804 0.161514961424942 4066 2248285
SGTC_3351 9150312 21.596 µM -0.988303681798805 0.168122275468725 no 2805 0.161501971407045 3995 4904905
SGTC_1768 st044301 37.178 µM -0.989468454558689 0.167793210950081 no 2806 0.161216998267474 4085 3931349
SGTC_1311 1190-0148 100 µM -0.99052411742774 0.167495329993726 no 2807 0.160959003500097 4144 1961333
SGTC_1467 k284-1082 293 µM -0.990921282449253 0.167383348477826 no 2808 0.160862009647789 4042 3334705
SGTC_1063 disulfiram 1.84 µM -0.99100257885959 0.167360432733059 no 2809 0.160842160510294 4081 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_662 k832-1615 104 µM -0.992577671223023 0.166916846477272 no 2810 0.160457905342246 4099 5878478
SGTC_2678 equilin 100 µM -0.994817888822116 0.166287251523279 no 2811 0.159912422087493 4093 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2964 9083345 53.42 µM -0.994926676175659 0.166256716818857 no 2812 0.159885963755196 4085 17741579
SGTC_684 1140-0066 328 µM -0.995187177478082 0.166183613386021 no 2813 0.159822618488716 4147 6813534
SGTC_1999 st074831 12.5 µM -0.995651332019028 0.166053411029293 no 2814 0.159709792209974 4038 17112523
SGTC_3101 9120531 49.47 µM -0.995781520952609 0.16601690290749 no 2815 0.159678155359468 4103 24824904
SGTC_2965 9082772 38.63 µM -0.995988549804288 0.165958857699164 no 2816 0.159627854300567 4101 16459634
SGTC_1574 spiramycin 23.7 µM -0.998133161022268 0.165358339327924 no 2817 0.159107395955821 4058 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_110 0850-0284 111.64 µM -0.998652477446533 0.165213135846164 no 2818 0.15898153462724 3891 3906265
SGTC_1973 st070275 50.2 µM -1.00161100790604 0.164387490661176 no 2819 0.158265751180023 4044 17118334
SGTC_2759 disulfiram 3.38 µM -1.00161976562731 0.164385050597529 no 2820 0.158263635491045 3994 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2721 ifenprodil 61.44 µM -1.00200879285797 0.164276684080219 no 2821 0.158169673073909 4078 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2647 atorvastatin 60.16 µM -1.00248460005098 0.164144207328152 no 2822 0.158054800327579 4065 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2786 7743617 45.45 µM -1.00274938737785 0.164070513860253 no 2823 0.157990897218701 4045 583674
SGTC_763 3453-1109 128 µM -1.00527258027276 0.163369356108033 no 2824 0.157382807252705 4117 1560353
SGTC_2790 5423970 71.43 µM -1.00529947085935 0.163361894112236 no 2825 0.157376334912432 4159 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_488 nitrendipine 139 µM -1.00689141292434 0.162920533149641 no 2826 0.156993479492832 4134 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_847 0342-0274 5.54 µM -1.00839049291482 0.16250562736014 no 2827 0.156633517596448 4102 18097
SGTC_2264 7948757 110.76 µM -1.00857978448649 0.162453285381807 no 2828 0.156588103213363 4052 2971411
SGTC_2528 xanthyletin 44.79 µM -1.00964857395113 0.162157954841132 no 2829 0.156331844457302 4139 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1430 4049-0248 69.1 µM -1.01119573623604 0.161731058881537 no 2830 0.15596137805774 4111 22774488
SGTC_874 0599-0792 117 µM -1.01234219330946 0.161415199148676 no 2831 0.155687233675732 4145 765305
SGTC_1423 4048-0112 5.59 µM -1.01293382965545 0.16125235522827 no 2832 0.155545884145353 4139 X1423
SGTC_851 0394-0702 453 µM -1.01542531512557 0.160567766979056 no 2833 0.15495156541557 4119 762646
SGTC_1852 st056254 31.4 µM -1.0160800465963 0.16038818114518 no 2834 0.154795634993365 4022 442583
SGTC_3308 9128332 17.569 µM -1.0172449160751 0.160068994527497 no 2835 0.154518466807099 4119 17332805 YDL196W YDL196W
SGTC_3013 9080133 71.4286 µM -1.0174427477781 0.160014827825032 no 2836 0.154471427483929 4197 17050193
SGTC_2370 9071495 200 µM -1.01762710670937 0.159964360784487 no 2837 0.154427600163648 4111 21791103
SGTC_279 1273-0055 2.93 µM -1.01843667212325 0.159742870828429 no 2838 0.154235240939809 4123 2847562
SGTC_2478 5763493 32.33 µM -1.02099776290923 0.159043501079021 no 2839 0.153627749301615 4042 1365576 YLR208W SEC13
SGTC_793 0488-0545 106 µM -1.02124326955159 0.158976564892782 no 2840 0.153569598369061 4131 292548
SGTC_1715 st032160 10.2275 µM -1.02141650603322 0.158929343922759 no 2841 0.153528574186807 4055 5289825
SGTC_1283 0922-0125 16.4 µM -1.0223046879097 0.158687386820007 no 2842 0.1533183575787 4111 3360884
SGTC_2976 9009005 19.48 µM -1.02234075472883 0.158677566659525 no 2843 0.153309825245108 4160 2993148
SGTC_1906 st060206 94.7 µM -1.02236406937808 0.158671218831932 no 2844 0.153304309861951 4146 5133468
SGTC_2960 9079389 5.97 µM -1.02270175749151 0.158579295912406 no 2845 0.153224440093358 4114 16457355
SGTC_1691 st019933 84.6 µM -1.02322777199497 0.158436177780151 no 2846 0.153100082429729 4101 6176082
SGTC_317 4495-0002 170 µM -1.02351422050669 0.158358276454814 no 2847 0.153032389876706 4140 15991618
SGTC_2170 morpholine 200 µM -1.02356663699335 0.158344024209217 no 2848 0.153020005135895 4161 121171 Reacts with secondary amines.
SGTC_2575 plumbagin 510 nM -1.02631913435214 0.157596791952499 no 2849 0.15237059047705 4025 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_685 1278-0033 54.9 µM -1.02806898083106 0.157122960224733 no 2850 0.15195869031511 4183 3590572
SGTC_2379 9035213 200 µM -1.02833699285985 0.157050469481567 no 2851 0.151895667762585 4118 646551
SGTC_2551 apiole 73.87 µM -1.02866720468683 0.156961185456931 no 2852 0.15181804291848 3997 10659 A possible DNA adduct former.
SGTC_1675 st018485 24.5 µM -1.03068409333673 0.156416575821208 no 2853 0.151344493234396 4168 3323024
SGTC_1513 0337-0559 19 µM -1.03340227528001 0.155684570756957 no 2854 0.150707841070873 4095 775073
SGTC_1238 0333-0287 48.8 µM -1.03343613633605 0.155675466261396 no 2855 0.150699921401938 4091 7226
SGTC_2217 6934799 96.0675 µM -1.03414151357111 0.155485885637016 no 2856 0.15053500568354 4093 675606
SGTC_216 k038-0035 28.382 µM -1.03493234466654 0.155273519205263 no 2857 0.150350254022269 4058 4444231 YPR107C YTH1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.03509830986526 0.155228975929544 no 2858 0.150311500904033 3974 4000243
SGTC_3177 9107506 49.47 µM -1.03682623856634 0.15476571952764 no 2859 0.149908422438451 4098 8897194
SGTC_226 1,3-diallylurea 8.28947 mM -1.03750298975512 0.154584532214028 no 2860 0.149750751540731 4069 74537 YKL182W FAS1
SGTC_1963 st076565 50.3 µM -1.03784789146234 0.154492245266059 no 2861 0.149670438197293 4141 4914280
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.03815506690052 0.154410083578788 no 2862 0.149598933941041 4096 15053
SGTC_692 k241-0027 77.8 µM -1.03818421435872 0.154402288869298 no 2863 0.149592150184048 4194 3600480
SGTC_759 3486-0358 89.3 µM -1.03886716630573 0.154219726065006 no 2864 0.149433259226573 4131 875103
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.04183709712965 0.153427482089782 no 2865 0.148743605822823 4124 364106
SGTC_2767 sibutramine 71.45 µM -1.04188271257186 0.153415334999572 no 2866 0.1487330299872 4169 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1145 3546-0597 10.2 µM -1.04189470851311 0.153412140665648 no 2867 0.148730248839214 4109 875334
SGTC_1710 st031758 61.5 µM -1.04209590494876 0.153358571727711 no 2868 0.148683608487645 4171 5394341
SGTC_2743 auranofin 4.32 µM -1.04303161560235 0.153109599814076 no 2869 0.148466825202024 4110 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2694 st077685 81.9 µM -1.04332883364487 0.1530305727594 no 2870 0.148398010666419 4082 2838096
SGTC_3247 9135149 49.47 µM -1.04350147238999 0.152984682405495 no 2871 0.14835804962125 4139 8934436 YOR116C RPO31
SGTC_2748 diazoxide 86.69 µM -1.04535816710767 0.152491717674914 no 2872 0.14792873166204 4186 3019 A potassium channel activatior.
SGTC_1114 scopoletin 1.73284 µM -1.04726321430686 0.151987011867829 no 2873 0.147489098562614 4177 5280460 A coumarin with genotoxic properties.
SGTC_2833 9001315 45.46 µM -1.04731499396862 0.15197330934394 no 2874 0.147477161456912 4103 2989378
SGTC_2875 9039966 71.43 µM -1.0482198694584 0.151733983358683 no 2875 0.147268659061799 4153 6463691
SGTC_1921 5740136 50 µM -1.04898528263513 0.151531738701776 no 2876 0.147092446046691 4102 1774243
SGTC_1635 st007035 42.4 µM -1.04975373626316 0.151328871033197 no 2877 0.146915675330183 4110 3716403
SGTC_3266 9136860 49.47 µM -1.04981604961471 0.151312428561192 no 2878 0.146901347368085 3986 4871271 YPR165W RHO1
SGTC_1035 k081-0041 55.2 µM -1.05134715183117 0.150908793641267 no 2879 0.146549589246442 4171 731709
SGTC_687 k029-0044 34.9 µM -1.05371266872672 0.150286597388334 no 2880 0.146007243490878 4227 5829338
SGTC_840 0245-0196 390 µM -1.05502151039097 0.149943071558115 no 2881 0.1457077435278 4230 3827528
SGTC_2033 5192550 145 µM -1.05531063341239 0.149867257395839 no 2882 0.145641639741625 4156 182073
SGTC_2074 5212007 75.395 µM -1.05640022444991 0.149581773372977 no 2883 0.145392701749223 4025 758611
SGTC_3312 9133330 71.43 µM -1.0590660241205 0.14888483749936 no 2884 0.144784855982599 4192 17617324
SGTC_2414 st077232 92.9 µM -1.06206937058966 0.148102258035165 no 2885 0.144102096923345 4101 729801
SGTC_2567 aureobasidin a 60 nM -1.06278544975175 0.147916077033977 no 2886 0.14393962971428 4308 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1826 st055655 41.6 µM -1.06299529508911 0.147861546821696 no 2887 0.14389204249295 4172 676168
SGTC_1042 0350-0096 82 µM -1.06301469993575 0.1478565049764 no 2888 0.143887642537059 4146 3122515
SGTC_482 fipronil 114 µM -1.06331588954281 0.147778263439464 no 2889 0.143819360875268 4253 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2099 5377090 177.372 µM -1.06397583279149 0.147606923608767 no 2890 0.143669823845237 4163 2243829
SGTC_3105 9121040 49.47 µM -1.06610085979123 0.147056111221902 no 2891 0.143189025500944 4033 41448907
SGTC_1777 st045864 34.765 µM -1.06921843531822 0.146250524900215 no 2892 0.142485626805086 4149 4691462
SGTC_514 4466-0038 2.65 nM -1.06947788199572 0.1461836173159 no 2893 0.142427195024801 3985 5722064
SGTC_1022 4477-0945 21.3 µM -1.0711721709218 0.145747190003502 no 2894 0.142046011072808 4113 4648966
SGTC_1368 1852-0141 284 µM -1.07126116908207 0.145724289444478 no 2895 0.142026007226146 4180 2838987
SGTC_497 capsazepine 133 µM -1.07307417376257 0.145258302726995 no 2896 0.14161891876062 4119 2733484 A calcium channel blocker.
SGTC_349 k015-0014 24 µM -1.07347971371314 0.14515420636658 no 2897 0.141527967918933 4159 2196908
SGTC_3135 9127742 49.47 µM -1.07390383919469 0.145045393081804 no 2898 0.141432891230651 4260 3643468
SGTC_2310 7668677 200 µM -1.07448731208533 0.14489578750092 no 2899 0.141302164202794 4186 2197143
SGTC_1445 4239-0156 97.7 µM -1.07491849182399 0.14478529748172 no 2900 0.141205611081704 4249 4008346
SGTC_1036 k216-0215 33.5 µM -1.07500397172942 0.144763399955016 no 2901 0.141186475070448 4145 622330
SGTC_588 3970-1144 52.9 µM -1.07664291002989 0.144343981794981 no 2902 0.140819913178571 4047 1888707
SGTC_73 0327-0325 16.231 µM -1.08226524481971 0.142911407501923 no 2903 0.139567342286996 4043 53298
SGTC_869 0564-0080 44.1 µM -1.08355974729079 0.142582933031887 no 2904 0.139280023185533 4173 6843321
SGTC_2716 st080858 38.6235 µM -1.08372645555488 0.142540668660011 no 2905 0.139243051008988 4151 5296050
SGTC_2085 5307070 144.047 µM -1.08406698731902 0.142454362372213 no 2906 0.139167549410788 4120 2840351
SGTC_1708 st033234 31.827 µM -1.08615221918652 0.141926640461976 no 2907 0.138705826288558 4275 674664
SGTC_1507 4075-3230 155 µM -1.08936064914586 0.141117252238119 no 2908 0.137997438616972 4109 659771
SGTC_988 1497-1057 103 µM -1.08946892602224 0.141089992018399 no 2909 0.137973575338926 4153 3533044
SGTC_916 4466-0038 42 nM -1.0902672594607 0.140889110628845 no 2910 0.137797716504715 4245 5722064 YGL116W CDC20
SGTC_2019 4016004 108 µM -1.09047819697986 0.140836065702353 no 2911 0.137751276228906 4211 45595336
SGTC_3176 9106582 49.47 µM -1.0933462938515 0.140116163601365 no 2912 0.137120892117195 4137 17018027
SGTC_3083 9117465 49.47 µM -1.09391480751632 0.139973762146866 no 2913 0.136996171904733 4186 16420915
SGTC_2076 5212012 200 µM -1.09422450991698 0.13989622920157 no 2914 0.136928262190096 4144 604802
SGTC_2665 lovastatin 100 µM -1.0994177541173 0.138600466007009 no 2915 0.135792945100769 4202 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2011 4012611 177 µM -1.09947096942235 0.13858723075065 no 2916 0.135781344944629 4187 2049887
SGTC_1636 st007707 68.9 µM -1.10019462301199 0.138407335278326 no 2917 0.135623666437971 4233 403051
SGTC_2715 st079500 56.4 µM -1.10039126038652 0.138358480044791 no 2918 0.135580842361344 4165 28246688
SGTC_877 0771-0151 33.1 µM -1.1012570804082 0.138143503906126 no 2919 0.135392392571195 4222 6166523
SGTC_827 3253-0474 693 µM -1.1041224109216 0.137433690104948 no 2920 0.134770020444668 4233 5402065
SGTC_2457 5731572 11.68 µM -1.10664182636848 0.136811628913225 no 2921 0.134224408008716 4243 2865357
SGTC_2913 7966556 36.57 µM -1.10669420124179 0.136798717646795 no 2922 0.134213081664265 4077 2976516
SGTC_3205 9113483 49.47 µM -1.11064910142237 0.135826175325914 no 2923 0.133359709423854 4237 17018033
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.11175841741409 0.135554237833867 no 2924 0.133121017556534 4232 551469
SGTC_1728 st035614 33.7865 µM -1.11644650427538 0.134409122129296 no 2925 0.132115528424552 4156 15945546
SGTC_2154 5570129 200 µM -1.11785776662666 0.134065710549707 no 2926 0.131813872541395 4258 673366
SGTC_352 k048-0007 5.11 µM -1.11837685243103 0.133939549822335 no 2927 0.131703038106919 4178 6811911
SGTC_3144 9087057 49.47 µM -1.11970021054738 0.133618284695171 no 2928 0.131420767649473 4109 17249618
SGTC_3024 9090631 49.47 µM -1.12039337011551 0.133450221385198 no 2929 0.131273084470686 4181 25236383
SGTC_2636 apigenin dimethyl ether 100 µM -1.12063295669935 0.13339216510488 no 2930 0.131222065299719 4207 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1605 st000082 49.1 µM -1.12133978820259 0.133220987949294 no 2931 0.131071627672739 4174 1114022
SGTC_1860 st056228 74.6 µM -1.12282830265836 0.13286100096177 no 2932 0.130755211268757 4195 688679
SGTC_1883 5-benzylidenerhodanine 20 µM -1.12604021758425 0.132086505028131 no 2933 0.130074248273299 4198 1273210
SGTC_2644 guaiazulene 100 µM -1.13105195265639 0.130884243708793 no 2934 0.129016612730106 4235 3515 A coloring agent.
SGTC_1176 0848-0131 83.3 µM -1.13149890253195 0.130777393712995 no 2935 0.128922582542477 4264 6769040
SGTC_1295 1013-0063 9.78 µM -1.13179540574732 0.130706543497804 no 2936 0.128860229847792 4245 6826038
SGTC_255 tunicamycin 200.472 nM -1.13312687401793 0.13038871283296 no 2937 0.128580488632097 4147 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1749 st037932 54.2 µM -1.13408243133934 0.13016094446084 no 2938 0.128379986180067 4256 594497
SGTC_472 calcifediol 10 µM -1.13722958698735 0.129412730091392 no 2939 0.127721160712018 4280 5283731 A vitamin D metabolite.
SGTC_1364 1653-0028 37.6 µM -1.13797688339398 0.129235504303307 no 2940 0.127565067582108 4218 5718652
SGTC_2452 5863136 48.41 µM -1.14036630403803 0.128669968213328 no 2941 0.127066862509401 4190 2184096
SGTC_193 1273-0060 1.558 µM -1.14201537753775 0.128280662920345 no 2942 0.126723813909648 4064 2847393 YHR072W ERG7
SGTC_2463 5473429 200 µM -1.14423149839298 0.12775878105861 no 2943 0.126263821717251 4219 5399405
SGTC_3014 9081533 49.47 µM -1.14464427426328 0.127661738318714 no 2944 0.126178272043235 4280 21367265
SGTC_2416 tofa 880 nM -1.14644454126809 0.127239098467676 no 2945 0.125805630934019 4231 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_395 anisomycin 6.25 µM -1.1502662123674 0.126345132608955 no 2946 0.125017121247151 4265 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2639 lactacystin 53 µM -1.15120457522032 0.126126301508379 no 2947 0.124824041709453 4288 3870 A proteasome inhibitor.
SGTC_3260 9137109 49.47 µM -1.15244097728197 0.125838369730234 no 2948 0.124569955272683 4190 17478346
SGTC_1174 0739-0097 51.1 µM -1.1536957384606 0.125546631541858 no 2949 0.124312465833341 4280 728447
SGTC_3055 9094636 49.47 µM -1.15544699908662 0.125140244355514 no 2950 0.12395371246653 4282 25236176
SGTC_1519 esterone 74 µM -1.1586704332136 0.124394636860453 no 2951 0.123295273555857 4207 698 A steroid.
SGTC_1422 4031-0024 15.5 µM -1.15937502949144 0.12423207239608 no 2952 0.123151675285562 4175 782427
SGTC_2166 5933061 31.504 µM -1.16006065837831 0.124074026803473 no 2953 0.123012055175493 4391 2877375
SGTC_3116 9124943 49.47 µM -1.16158516698536 0.123723113804623 no 2954 0.122702005045093 4232 41905195 YPL160W CDC60
SGTC_960 1222-0186 7.7 µM -1.16307741496358 0.123380300132688 no 2955 0.122399047264881 4265 3126296
SGTC_1707 st032323 6.317 µM -1.16352665629567 0.123277226505252 no 2956 0.122307944706415 4112 3132057 YMR211W DML1
SGTC_1568 digitonin 820 nM -1.16586881521521 0.122740820495871 no 2957 0.121833744533328 4241 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2095 5432005 200 µM -1.16776597124755 0.122307531615468 no 2958 0.121450588875034 4255 783734
SGTC_1652 st011932 78 µM -1.16918242900611 0.121984729585381 no 2959 0.121165069463831 4197 1551076
SGTC_2710 st078562 53.7235 µM -1.16932996239146 0.121951142071898 no 2960 0.121135357911634 4200 17250908
SGTC_5 0352-0601 109.883 µM -1.17024604184102 0.121742732420597 no 2961 0.120950984596098 4171 762456
SGTC_564 3555-0129 330 µM -1.17118254196434 0.121529935848448 no 2962 0.120762705548655 4137 563260
SGTC_701 4424-0219 185 µM -1.1715010880824 0.121457613719413 no 2963 0.120698710359774 4298 2911779
SGTC_3219 9131112 49.47 µM -1.17384379623417 0.120926658978271 no 2964 0.120228798994092 4160 17612988 YMR079W SEC14
SGTC_1182 1222-0449 220 µM -1.1744072220384 0.120799207352792 no 2965 0.120115976947159 4267 658318
SGTC_964 1287-0107 19.4 µM -1.17472150316278 0.120728155427734 no 2966 0.120053076791819 4285 51516812 YPR165W RHO1
SGTC_1121 fusaric acid 630.51 nM -1.17808456850936 0.119969683006338 no 2967 0.119381446694232 4224 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1941 st076221 61.8 µM -1.1855005142494 0.118309049850524 no 2968 0.117909805727804 4153 2828568
SGTC_2492 derrusnin 100 µM -1.18984243139103 0.11734435238643 no 2969 0.117054164387917 4291 1715307 Part of coumarin class of compounds.
SGTC_3143 9086658 49.47 µM -1.1898956324192 0.11733256670547 no 2970 0.117043707665836 4312 25236626
SGTC_2240 6690706 185.951 µM -1.19293700519897 0.116660201479229 no 2971 0.116447022585332 4162 805876
SGTC_989 1501-0895 10.3 µM -1.19315148361717 0.11661288944026 no 2972 0.116405025790498 4241 2830112
SGTC_2589 lobaric acid 100 µM -1.19326652224382 0.116587518545368 no 2973 0.116382504624893 4254 73157 A novel microtubule depolymerizer.
SGTC_817 1391-0715 46 µM -1.19429619779766 0.116360605739392 no 2974 0.116181062211054 4262 1353946
SGTC_3129 9127257 49.47 µM -1.19694257690454 0.115778852896947 no 2975 0.115664468688332 4231 837894
SGTC_137 0438-0332 85.389 µM -1.1982863863099 0.115484235664221 no 2976 0.115402772308614 4239 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1312 1218-2183 165 µM -1.19892029570446 0.115345442223395 no 2977 0.115279469582071 4346 6744073
SGTC_579 4491-1009 110 µM -1.19893375492541 0.115342496634531 no 2978 0.115276852623208 4397 1271041
SGTC_963 1269-2853 151 µM -1.19928250059965 0.115266191289229 no 2979 0.115209058585788 4258 3668223
SGTC_12 0849-0099 9.267 µM -1.20102628757748 0.114885190022615 no 2980 0.114870502188113 4203 6071388
SGTC_2795 7780010 54.55 µM -1.20139751733172 0.11480419555311 no 2981 0.114798519358956 4254 953673
SGTC_1427 4048-4900 550 nM -1.20335099994029 0.114378656341534 no 2982 0.114420260557797 4283 24132586
SGTC_4 0960-0234 25.671 µM -1.20497688567224 0.114025336842681 no 2983 0.114106112584364 4301 6821112
SGTC_597 k018-0003 82.8 µM -1.20725247101611 0.113532138521636 no 2984 0.113667464330201 4360 6786234
SGTC_1988 st071872 53.4 µM -1.20896855858576 0.113161210195772 no 2985 0.113337462458849 4321 16414116
SGTC_1057 3448-5381 134 µM -1.21232097430054 0.112439089630195 no 2986 0.112694769058668 4284 5497911
SGTC_1309 pyrazolanthrone 13.4 µM -1.21361986500251 0.112160191363198 no 2987 0.112446458863028 4264 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_24 0417-1663 219 µM -1.21467087893447 0.111934879484746 no 2988 0.112245821799225 4326 4329390
SGTC_2373 9071805 200 µM -1.21818085888537 0.111184770710198 no 2989 0.111577625915134 4313 10149009
SGTC_1997 st073024 93.8 µM -1.22126261366145 0.110529149988121 no 2990 0.11099330195864 4318 686268
SGTC_2021 4019055 173 µM -1.22169507753136 0.110437368669043 no 2991 0.110911479237416 4129 44827708 YER133W GLC7
SGTC_3165 9101544 49.47 µM -1.22461357957607 0.10981940671697 no 2992 0.110360424496578 4305 5002184
SGTC_1030 k029-0042 36.7 µM -1.22886205630924 0.108924278829942 no 2993 0.109561764921324 4285 6080581
SGTC_3293 9120939 62.045 µM -1.23189990679266 0.108287446516839 no 2994 0.108993238122862 4305 934087
SGTC_3057 9095946 49.47 µM -1.23790194970661 0.10703710933431 no 2995 0.107876209660947 4370 24540043
SGTC_1994 st072947 40.9 µM -1.24128018868165 0.106337955995727 no 2996 0.107251130342037 4366 5286565 YDL195W SEC31
SGTC_1881 5652484 16 µM -1.24464013756334 0.105645865126702 no 2997 0.106632029742679 4302 2255129
SGTC_1741 st038134 10.228 µM -1.24722633646305 0.105115375776539 no 2998 0.106157259363171 4380 1272587
SGTC_1396 3511-0007 98.6 µM -1.25182694790891 0.104176453743894 no 2999 0.105316464219493 4360 X1396
SGTC_2468 5987765 72.9 µM -1.25553526059416 0.103424074569059 no 3000 0.104642258093461 4378 26772094
SGTC_862 0452-0056 10.2 µM -1.25586172787904 0.103358027046795 no 3001 0.104583053338476 4290 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2981 9013952 38.96 µM -1.2563855613049 0.103252114416206 no 3002 0.104488106996345 4289 2996344
SGTC_3257 9139206 32.98 µM -1.25813532094929 0.102898905960961 no 3003 0.104171410673102 4335 4910041
SGTC_2766 oltipraz 83.91 µM -1.25877813257042 0.102769368019604 no 3004 0.104055240453845 4300 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2909 7941780 10.49 µM -1.25982262276012 0.10255913751252 no 3005 0.103866678435711 4309 1243215
SGTC_213 1246-0773 967 nM -1.26132762690385 0.102256766784879 no 3006 0.103595415761166 4353 6251622
SGTC_1588 farnesol 29.9 µM -1.2619556510032 0.102130782247022 no 3007 0.103482372543314 4347 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_742 0kpi-0133 140 µM -1.2649089845149 0.10153984389209 no 3008 0.102951978139448 4360 2728852
SGTC_996 3970-0799 1.8 µM -1.26840485777633 0.100843570742222 no 3009 0.102326703872686 4322 6615648 YGL040C HEM2
SGTC_131 0141-0277 33.849 µM -1.27059325671441 0.100409482770309 no 3010 0.101936693577142 4309 1547771
SGTC_958 1222-0007 33 µM -1.27255250075356 0.100022007885588 no 3011 0.101588441437712 4413 7312461
SGTC_2372 9071633 200 µM -1.27605282038365 0.0993324781064319 no 3012 0.100968423929867 4392 21321366
SGTC_1526 st051518 75 µM -1.27619468860662 0.0993046048742205 no 3013 0.100943352870481 4334 673993
SGTC_676 falcarinol 140 µM -1.27798772403915 0.0989528151098515 no 3014 0.100626877376097 4383 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2499 avocadenofuran 51.48 µM -1.27851669275784 0.0988492069293781 no 3015 0.100533651398051 4302 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2583 asiatic acid 100 µM -1.27885690402813 0.098782612297988 no 3016 0.100473725527143 4372 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1778 st046819 58.9 µM -1.27946363715002 0.0986639288626633 no 3017 0.100366918362964 4389 671715
SGTC_1782 st039423 80.636 µM -1.27948597352262 0.0986595616239652 no 3018 0.100362987928438 4380 2068169
SGTC_2892 9047358 58.44 µM -1.28035856486102 0.0984890620662547 no 3019 0.100209529713605 4346 6466771
SGTC_1682 st012968 530 nM -1.28432314725197 0.0977171208391402 no 3020 0.0995144554750392 4361 24207270
SGTC_1616 st002734 56.1 µM -1.28510202327313 0.097565989153183 no 3021 0.0993783173287378 4302 4026101
SGTC_1725 st036284 20.55 µM -1.28666605018762 0.09726302605459 no 3022 0.0991053555488019 4399 707914
SGTC_2079 5212404 121 µM -1.28789774403972 0.0970249245054313 no 3023 0.0988907804509658 4311 758462
SGTC_2399 5884133 200 µM -1.28806602716668 0.0969924265605395 no 3024 0.0988614900268914 4331 722445
SGTC_2616 abietic acid 100 µM -1.28906966576103 0.0967987751206644 no 3025 0.0986869340950312 4383 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2272 7805186 180 µM -1.29162457902445 0.0963070878110551 no 3026 0.0982435939248872 4380 2956062 YPR165W RHO1
SGTC_1878 temozolomide 1 mM -1.29324651688792 0.0959959034979814 no 3027 0.0979629059499698 4299 5394 DNA alkylating agent.
SGTC_574 1315-0397 40 µM -1.29389208494273 0.0958722510165423 no 3028 0.0978513494326036 4343 6794277
SGTC_1221 2958-7315 257 µM -1.29468310858265 0.0957208976554582 no 3029 0.0977147846436633 4385 4562705
SGTC_441 propafenone 146 µM -1.29615035214676 0.0954406228901849 no 3030 0.097461845209848 4348 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2371 9071574 200 µM -1.29621142274824 0.095428970213268 no 3031 0.0974513276143472 4370 45596039
SGTC_2231 micatex 6.853 µM -1.29697425541687 0.0952835048953799 no 3032 0.0973200225057744 4379 20737 An antifungal of unknown mechanism.
SGTC_2187 6125751 200 µM -1.29967826387865 0.0947691898607918 no 3033 0.0968556315827899 4378 874498
SGTC_1559 coumarin 343 70.1 µM -1.30440896093776 0.0938743146462078 no 3034 0.0960470907587673 4405 108770 A hepatotoxic, DNA x-linker.
SGTC_459 nigericin 15.3 µM -1.31222313311177 0.0924098428756946 no 3035 0.0947224293735322 4437 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2988 9073640 71.4286 µM -1.31440810385925 0.0920033929473835 no 3036 0.0943544523965539 4411 9102229
SGTC_470 aa-861 153 µM -1.3202198656507 0.0909287302445301 no 3037 0.0933808105980703 4334 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1692 fluoroquinolonic acid 71 µM -1.321064143996 0.0907733911890331 no 3038 0.0932399886842297 4389 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3277 9138724 49.47 µM -1.32107534501173 0.0907713316348739 no 3039 0.0932381214593703 4340 15943418
SGTC_2905 7799065 20.05 µM -1.32585616073872 0.0898954357509836 no 3040 0.0924436732097062 4269 1296806
SGTC_3306 9127676 59.7925 µM -1.32786658897374 0.0895289860779348 no 3041 0.0921110919995158 4344 41905287
SGTC_158 k038-0087 26.446 µM -1.32800865333076 0.0895031334629817 no 3042 0.092087624124203 4288 X158
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.3302123059098 0.0891028274719173 no 3043 0.0917241653728465 4435 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1108 betulinic acid 729.144 nM -1.33179228207171 0.0888166370523102 no 3044 0.0914642274011244 4379 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2472 5377652 49.4 µM -1.33224777416483 0.0887342583178497 no 3045 0.0913893912438882 4448 1610903
SGTC_757 1066-0008 322 µM -1.333619105878 0.0884865875210461 no 3046 0.0911643590783399 4417 6842497
SGTC_1563 conessine 56.1 µM -1.33614716536168 0.0880313551973516 no 3047 0.0907505881667338 4468 441082 An anti-amoebic, histamine inhibitor.
SGTC_586 0957-0265 8.15 µM -1.33875710433749 0.0875632130488184 no 3048 0.0903248797248244 4265 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2106 5357045 167.29 µM -1.34084212301528 0.0871905621676691 no 3049 0.0899858583354894 4409 668842
SGTC_566 0958-0068 16.5 µM -1.34280189359738 0.0868413774597708 no 3050 0.0896680650456923 4291 6815365
SGTC_3214 9129694 49.47 µM -1.34423865078678 0.0865860459017366 no 3051 0.0894356134352004 4423 17158655
SGTC_154 3389-1638 511.116 µM -1.34726389101474 0.0860502544569758 no 3052 0.0889476286068008 4393 5238686
SGTC_1024 4507-0395 26 µM -1.34809311716594 0.0859038266964687 no 3053 0.0888142174541686 4454 4201836
SGTC_412 gemfibrozil 100 µM -1.34949301219971 0.0856570514050274 no 3054 0.0885893316570618 4344 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_545 4218-0007 221 µM -1.35974998345357 0.0838651077889997 no 3055 0.0869545274885275 4399 2840508
SGTC_1874 staurosporine 7.6 µM -1.36090136056553 0.0836657272736302 no 3056 0.0867724317580522 4413 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1617 st002906 78 µM -1.36844942330546 0.0823674629311933 no 3057 0.0855857214988548 4396 5150859
SGTC_2925 9010536 32.5 µM -1.37080449230519 0.0819655127292137 no 3058 0.0852179550919762 4333 2994177
SGTC_1468 k284-1086 134 µM -1.37166635501506 0.0818187847580008 no 3059 0.0850836634068157 4409 15996457
SGTC_549 1661-1316 519 µM -1.37289053033622 0.0816107152269887 no 3060 0.0848931904645978 4431 2857282
SGTC_1972 st070201 17.4 µM -1.37445384305839 0.081345583858794 no 3061 0.0846504151686645 4436 2829099
SGTC_626 0214-0009 33 µM -1.37546501169038 0.0811744402092302 no 3062 0.0844936628778893 4475 3437874
SGTC_596 1155-0152 116 µM -1.37547645676363 0.081172504648768 no 3063 0.0844918898993016 4444 280313
SGTC_3334 9142812 21.919 µM -1.37708094160241 0.0809015029341834 no 3064 0.0842436121577543 4424 45283678
SGTC_3125 9127534 49.47 µM -1.37993653317014 0.0804208763764985 no 3065 0.0838030934526196 4328 1639235
SGTC_2125 5246583 200 µM -1.3833621401505 0.0798471601229215 no 3066 0.0832769265740716 4432 835267
SGTC_2876 9059903 25.97 µM -1.38369104177549 0.0797922393833398 no 3067 0.0832265388663546 4412 6916095
SGTC_1678 st019265 80.2 µM -1.38605103151729 0.0793990006831911 no 3068 0.0828656607270661 4413 5367020
SGTC_3201 9113999 49.47 µM -1.38670429960269 0.0792904080329022 no 3069 0.0827659744967072 4398 16649224
SGTC_186 3455-3465 67.277 µM -1.38835906752553 0.0790158393699875 no 3070 0.0825138670087712 4427 755278
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.39138063967634 0.0785163414932891 no 3071 0.0820550161316076 4391 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_113 0099-0221 2.5 µM -1.39367851089941 0.078138084116134 no 3072 0.0817073541180126 4399 89219
SGTC_3341 9147222 25.867 µM -1.39460271444257 0.0779863394192536 no 3073 0.08156783804566 4433 1939759
SGTC_2522 biochanin a 4.94 µM -1.40043787567985 0.077033424133747 no 3074 0.0806911173115602 4432 5280373 A possible chelator.
SGTC_943 3253-1379 105 µM -1.40237759746533 0.0767186240651642 no 3075 0.0804012597520896 4424 668464
SGTC_1386 3228-0095 33.8 µM -1.40252988962844 0.0766939498421649 no 3076 0.0803785356979316 4429 870181
SGTC_3259 9138485 49.47 µM -1.40339919684548 0.0765532210871565 no 3077 0.0802489161850841 4426 17646153
SGTC_1373 2887-0003 58.5 µM -1.40388791172603 0.0764741912404028 no 3078 0.0801761149357846 4391 776948
SGTC_2458 5808907 16.39 µM -1.40502147710752 0.0762911218890339 no 3079 0.0800074459426376 4559 2731747
SGTC_327 1273-0057 3.96 µM -1.4052021877235 0.0762619682033379 no 3080 0.0799805818974516 4338 3108138
SGTC_1995 st072814 61.1 µM -1.40605679901213 0.076124210304121 no 3081 0.0798536296397006 4423 5769371
SGTC_3041 9091929 49.47 µM -1.40863466309209 0.0757098224168412 no 3082 0.07947161184366 4428 25236887
SGTC_3340 9146634 11.102 µM -1.40875307379524 0.0756908294285815 no 3083 0.0794540976542377 4422 4907387
SGTC_3131 9127911 49.47 µM -1.41226836255995 0.0751286316343444 no 3084 0.0789354790812137 4445 45595681
SGTC_3346 9158254 43.5805 µM -1.41275182692873 0.0750515612260409 no 3085 0.0788643535251568 4464 17639500
SGTC_359 0081-0058 15.9 µM -1.41542415730588 0.0746266449039227 no 3086 0.0784720854345366 4476 3494159
SGTC_1141 3253-0389 52.6 µM -1.41591942263243 0.0745480968554491 no 3087 0.0783995487954587 4429 5402031
SGTC_1876 myriocin 605 nM -1.41595567127186 0.0745423503761532 no 3088 0.0783942418111563 4434 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_891 0929-0073 133 µM -1.41635134532038 0.0744796463472888 no 3089 0.0783363308397015 4474 5603632
SGTC_1262 0737-0114 49.6 µM -1.41872956295344 0.074103608850733 no 3090 0.0779889374493587 4470 765919
SGTC_2612 dictamnine 15.46 µM -1.41963996693754 0.0739600426545194 no 3091 0.0778562618239084 4377 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1971 st069429 63.5 µM -1.42188420853743 0.0736070446239638 no 3092 0.0775299341043108 4451 1246522 YGL099W LSG1
SGTC_1278 0874-0585 172 µM -1.42234628625299 0.0735345243329051 no 3093 0.0774628740413513 4508 766306
SGTC_479 n-linoleoylglycine 10 µM -1.42484645228262 0.0731430856632245 no 3094 0.0771007956122306 4484 6433346 An anti-infammatory.
SGTC_1529 apigenin 74 µM -1.42758948398542 0.0727154591314161 no 3095 0.0767050261034507 4448 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1210 3013-0140 750 nM -1.43156993946643 0.07209833185157 no 3096 0.0761334688759021 4474 905973
SGTC_2134 5324836 1.464 µM -1.43538422126648 0.071510742713501 no 3097 0.075588819900453 4435 699272
SGTC_1923 st058458 19.1 µM -1.43672085540661 0.0713057063437346 no 3098 0.0753986632902805 4458 3534982
SGTC_3202 9113761 49.47 µM -1.44233761519516 0.070449038956366 no 3099 0.0746035768066714 4388 4798415
SGTC_1800 st050079 29.0735 µM -1.44254370844611 0.0704177567961046 no 3100 0.0745745252322684 4279 3645560
SGTC_2825 7998094 58.44 µM -1.44342954052481 0.0702834210901735 no 3101 0.0744497537767238 4432 2987815
SGTC_156 3474-0145 5.642 µM -1.44351450710967 0.0702705463426308 no 3102 0.0744377944221072 4382 2265471
SGTC_1540 guanosine 70.6 µM -1.44630489215161 0.0698487342321132 no 3103 0.0740458521073188 4393 6802 Guanosine is a purine nucleoside
SGTC_1395 3486-0190 4.35 µM -1.45323040125308 0.0688102519091461 no 3104 0.0730798969628628 4445 6748079
SGTC_650 1328-0195 38 µM -1.46139313363645 0.0676015780689643 no 3105 0.0719537919844078 4478 2780821
SGTC_1546 5-methoxyflavanone 78.7 µM -1.46168602675096 0.0675585155651023 no 3106 0.0719136340417998 4498 147795
SGTC_1924 st058459 75.1 µM -1.46393288472661 0.0672288767343342 no 3107 0.0716061435952499 4434 688683
SGTC_1774 st048371 48.465 µM -1.46428344048829 0.067177558674912 no 3108 0.0715582599073091 4471 4242727
SGTC_257 daunorubicin 18.5 µM -1.46499727506583 0.0670731536622156 no 3109 0.0714608306007905 4508 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1209 2323-2347 50.3 µM -1.47238462450732 0.0660000407323843 no 3110 0.0704585213915286 4485 5412760
SGTC_1146 3579-1023 7 µM -1.47392201632358 0.0657783951465604 no 3111 0.0702512945879097 4489 X1146
SGTC_2276 7947513 42.08 µM -1.47468388814007 0.065668770201608 no 3112 0.0701487748628785 4410 2105100
SGTC_2216 7189485 200 µM -1.47597937817437 0.0654826887464851 no 3113 0.0699747141535412 4492 731273
SGTC_1085 doxorubicin 7.67 µM -1.47598094405788 0.0654824640739788 no 3114 0.0699745039643074 4487 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1142 3253-1408 9.78 µM -1.48014912257517 0.0648865309863996 no 3115 0.0694167273128823 4494 256655
SGTC_2082 5219693 150 µM -1.48592993628152 0.0640670157499884 no 3116 0.068648827137035 4438 2834649
SGTC_1453 4237-0541 195 µM -1.48810048240745 0.0637613952742588 no 3117 0.0683621981435243 4493 739892
SGTC_1620 st003704 16.5 µM -1.48863714659695 0.0636860062273621 no 3118 0.0682914721495723 4494 2834414
SGTC_1448 4255-0083 152 µM -1.4893495706565 0.0635860340952719 no 3119 0.0681976703346297 4509 5399660
SGTC_2709 st078560 56 µM -1.49088358686503 0.0633711852236965 no 3120 0.0679960306378657 4477 17250903
SGTC_251 melphalan 456.522 µM -1.49136222163234 0.0633042651282567 no 3121 0.0679332105095119 4527 460612 A DNA alkylator.
SGTC_1321 1326-2144 215 µM -1.49153779192683 0.0632797316462541 no 3122 0.0679101783976962 4456 3513030
SGTC_2001 4023502 57.655 µM -1.49197753495138 0.0632183162258854 no 3123 0.0678525173688927 4487 108941 YCR052W RSC6
SGTC_737 1950-0117 57.9 µM -1.4935114143743 0.0630044546925179 no 3124 0.0676516843261693 4495 5393513
SGTC_406 estrone 100 µM -1.50065535141599 0.0620158256555311 no 3125 0.0667223634409918 4487 5870 A steroid.
SGTC_222 nsc-310342 10.666 µM -1.50548358565092 0.0613545443063885 no 3126 0.0660998969026283 4519 432556
SGTC_2671 danthron 100 µM -1.50562421235326 0.061335366769419 no 3127 0.0660818346535333 4497 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1301 naphtanilide LB 4.81 µM -1.50645317126262 0.0612224151808858 no 3128 0.0659754399475484 4547 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2815 7968870 71.43 µM -1.51005968306773 0.0607328929373933 no 3129 0.0655140978901466 4426 2977326 YHR190W ERG9
SGTC_1358 1509-0022 2.48 µM -1.51108152052693 0.0605947539894491 no 3130 0.0653838411447609 4536 3258434
SGTC_2228 7354201 200 µM -1.51211282257209 0.0604555848961184 no 3131 0.0652525816915112 4594 753451
SGTC_1726 st035556 14.5795 µM -1.51737979583436 0.0597487296501972 no 3132 0.0645854110047245 4536 5919439
SGTC_3185 9108267 49.47 µM -1.5175635949439 0.0597241802745509 no 3133 0.0645622250971814 4491 4910486
SGTC_1332 1480-0653 17.5 µM -1.52190509688187 0.0591465966943307 no 3134 0.0640164309471266 4507 5749438
SGTC_83 0170-0301 39.027 µM -1.52345234791121 0.058941816024164 no 3135 0.0638227869400301 4535 3089716
SGTC_628 1636-0253 16 µM -1.53017314272659 0.0580587593895541 no 3136 0.0629869386753185 4499 4456143
SGTC_2863 9028737 58.44 µM -1.53099706945654 0.0579512214425096 no 3137 0.062885058463697 4498 6460917
SGTC_1643 st009866 20.2 µM -1.53329891442438 0.0576516168981849 no 3138 0.0626011109898065 4475 3156273 YOR207C RET1
SGTC_2394 5221648 200 µM -1.53707172650785 0.0571631895522889 no 3139 0.0621378728787967 4539 788586
SGTC_2109 5483026 200 µM -1.53713554307726 0.0571549559739068 no 3140 0.0621300603356315 4525 759335
SGTC_116 0155-0182 31.788 µM -1.53892557591301 0.0569243870169929 no 3141 0.0619112332420835 4387 771486
SGTC_2728 chlorpromazine 9.18 µM -1.53957246137141 0.0568412439674651 no 3142 0.0618323012230168 4611 2726 A thorazine and dopamine antagonist.
SGTC_1079 idarubicin 2.36 µM -1.5421926258851 0.056505456663803 no 3143 0.0615133957488761 4544 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_926 2268-1401 59.4 µM -1.54258432576643 0.0564553929337935 no 3144 0.0614658317424288 4490 2931578
SGTC_1173 0443-0020 122 µM -1.54357155044072 0.0563293693931271 no 3145 0.0613460807638139 4512 5331295
SGTC_2316 5844804 197.44 µM -1.54591263097987 0.0560314066830361 no 3146 0.061062834816901 4526 776813
SGTC_151 3013-0144 2.285 µM -1.55353669469497 0.0550696578208961 no 3147 0.0601474849149853 4276 906558 YHR107C CDC12
SGTC_1499 4480-0877 67.3 µM -1.55595424888397 0.0547674304698843 no 3148 0.0598594859998372 4515 2861909
SGTC_111 0083-0039 52.457 µM -1.55861945032587 0.0544357649644962 no 3149 0.0595432383387268 4498 759313
SGTC_1492 4158-0558 28.5 µM -1.55876416130354 0.0544178022773417 no 3150 0.0595261047654003 4528 3967268
SGTC_1882 5615643 20 µM -1.56033110792334 0.0542236004063115 no 3151 0.0593408278811958 4500 2253075
SGTC_1257 0669-0121 16 µM -1.56223061188644 0.0539889183411429 no 3152 0.0591168357819102 4512 4307855
SGTC_3198 9112019 49.47 µM -1.5662225558126 0.0534983379934001 no 3153 0.0586482619809114 4571 45595555
SGTC_1434 4073-0095 163 µM -1.56765996895651 0.0533225578982897 no 3154 0.0584802543363987 4530 24133745
SGTC_2650 prasterone 100 µM -1.57535143812071 0.052389739677713 no 3155 0.0575876734896681 4560 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1196 1588-0294 184 µM -1.57577143291632 0.0523391783060564 no 3156 0.0575392440987915 4565 6144269
SGTC_1872 amphotericin b 148 nM -1.57642264117909 0.0522608587563589 no 3157 0.0574642169478144 4544 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3133 9127736 49.47 µM -1.57723913604957 0.0521627920394425 no 3158 0.0573702555240542 4534 27243420
SGTC_85 0868-0259 160.055 µM -1.58066320123954 0.0517531287162536 no 3159 0.056977533290981 4483 83173
SGTC_785 1270-0111 65.3 µM -1.58089336848391 0.051725682947584 no 3160 0.0569512104334001 4452 6741994
SGTC_2564 betulinic acid 100 µM -1.58243879285112 0.0515417018625441 no 3161 0.05677471735781 4528 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1851 st056236 18.9 µM -1.59473666658537 0.0500961364300728 no 3162 0.055385567481006 4512 5393171
SGTC_1244 0416-0015 52.5 µM -1.59619125997242 0.0499273139277038 no 3163 0.0552230491737496 4524 96201
SGTC_666 0272-0154 136 µM -1.60032044731612 0.049450544957013 no 3164 0.0547637565268905 4547 6870312
SGTC_1657 st012939 43.4 µM -1.60195191355443 0.0492631752526799 no 3165 0.0545831216880938 4533 24207257
SGTC_2251 lansoprazole 556 µM -1.60558965044267 0.0488474317249328 no 3166 0.0541820504725999 4528 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2202 7226349 200 µM -1.60612108714898 0.0487869311920729 no 3167 0.0541236537447502 4567 844334
SGTC_2491 paeonol 100 µM -1.60660092638101 0.0487323561504797 no 3168 0.0540709695893148 4524 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3235 9132602 49.47 µM -1.60862587174715 0.0485025840278265 no 3169 0.0538490867888674 4532 4912240
SGTC_298 1391-0729 10 µM -1.60980212260461 0.0483695122026906 no 3170 0.0537205308496881 4509 3237558
SGTC_925 2064-1272 59.6 µM -1.61026997776588 0.0483166639692679 no 3171 0.053669465192356 4527 6815817
SGTC_1525 8-methoxypsoralen 92.5 µM -1.61188971422173 0.0481340575800198 no 3172 0.0534929704231776 4572 4114 Related to psoralen; DNA damaging agent.
SGTC_3237 9133362 49.47 µM -1.6121083164073 0.0481094550839988 no 3173 0.0534691856728922 4532 43845137
SGTC_63 0099-0242 26.702 µM -1.61498436394308 0.0477867076537371 no 3174 0.0531570405020833 4561 3898502 YLR359W ADE13
SGTC_3136 9095672 49.47 µM -1.61773242029512 0.0474799451782453 no 3175 0.0528601379706264 4412 17217380
SGTC_2215 7188065 200 µM -1.62000595516901 0.0472273473084703 no 3176 0.0526154988360069 4613 940217
SGTC_568 1193-0097 7.48 µM -1.6245318096483 0.0467277154650056 no 3177 0.0521311785820907 4341 3646150
SGTC_3233 9132340 49.47 µM -1.62499749261551 0.0466765478988514 no 3178 0.0520815465481648 4566 17682950
SGTC_1481 3346-2004 36 µM -1.63355509105634 0.0457442489244551 no 3179 0.0511761520379684 4633 2770522
SGTC_2016 5121758 140 µM -1.63397216763748 0.0456991962343234 no 3180 0.0511323474073633 4486 2795203
SGTC_2627 acetyl isogambogic acid 100 µM -1.63916645334639 0.045141091378228 no 3181 0.0505892991445548 4566 6857789 A caspase activator and apoptosis inducer.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.64182839734478 0.0448572092216833 no 3182 0.05031278609201 4593 77254
SGTC_365 0121-0052 13.6 µM -1.642395734155 0.0447968919742755 no 3183 0.0502540092096635 4547 3101739
SGTC_2523 spermine 47.74 µM -1.64334678436334 0.044695926184223 no 3184 0.0501556018691455 4563 1103 A DNA binding polyamine.
SGTC_2982 9019404 25.97 µM -1.65156255815167 0.0438313298956227 no 3185 0.0493118790233909 4519 22333232
SGTC_1788 fluconazole 20 µM -1.65207664329943 0.0437776812162281 no 3186 0.04925946383532 4564 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_792 4534-1957 155 µM -1.65471345215552 0.0435033423874586 no 3187 0.0489913185144814 4543 1717904
SGTC_318 1488-0629 67.2 µM -1.65599631475496 0.0433703735121538 no 3188 0.0488612825636964 4604 3662576
SGTC_2253 7938677 135.83 µM -1.66400794969679 0.042547373270142 no 3189 0.0480554203683738 4603 2301972
SGTC_2408 sulbentine 18.36 µM -1.66466757377359 0.0424801794978233 no 3190 0.0479895478391941 4430 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2397 5161689 200 µM -1.66959435272225 0.0419810147071431 no 3191 0.0474998242450826 4575 2259942
SGTC_1025 k007-0731 70 µM -1.67014010306376 0.0419260144322331 no 3192 0.047445823662731 4558 6256118
SGTC_1087 pterostilbene 9.05 µM -1.67388384398141 0.041550294199272 no 3193 0.0470767149808697 4574 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1940 st075990 51.1 µM -1.67646337821812 0.0412930041288952 no 3194 0.0468237318558151 4604 1084979
SGTC_370 0180-0345 38.7 µM -1.67777139400494 0.0411630332354059 no 3195 0.0466958679024936 4429 3989527
SGTC_1955 wogonin 32.4 µM -1.68041865368096 0.0409010034403021 no 3196 0.0464379446040347 4553 5281703 A flavanone.
SGTC_1012 4112-3522 18 µM -1.68208770981325 0.0407364943451646 no 3197 0.0462759166131366 4578 3112398
SGTC_585 0kpi-0023 191 µM -1.68785879837635 0.040171805575218 no 3198 0.0457191686841389 4514 64601
SGTC_82 0054-0107 293.755 µM -1.69676270332691 0.0393130663662901 no 3199 0.0448707663252236 4563 3104697
SGTC_1464 k208-0027 110 µM -1.70209656070963 0.0388058356539233 no 3200 0.0443686342742609 4574 X1464
SGTC_506 n9-isopropylolomoucine 153 µM -1.70418627478499 0.0386085702905836 no 3201 0.0441731462740077 4604 6610355
SGTC_539 4859-0462 2.54 µM -1.70643560503564 0.0383971513412589 no 3202 0.0439635030919142 4604 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1895 st058434 18.3 µM -1.71144629357632 0.0379295789187091 no 3203 0.0434993787430105 4590 5393175
SGTC_738 1315-0003 72.4 µM -1.71286451130693 0.0377980847473871 no 3204 0.0433687342538907 4595 6251474
SGTC_2284 7945075 39.21 µM -1.72377163749002 0.0367991866602618 no 3205 0.0423745383475848 4552 1245402
SGTC_2159 5658611 73.75 µM -1.73628041625653 0.0356802900822761 no 3206 0.0412571321188224 4584 793844
SGTC_703 3875-0075 71.8 µM -1.74198089780661 0.0351797178178005 no 3207 0.0407558934263886 4646 2850814
SGTC_3222 9128301 49.47 µM -1.74822889200947 0.0346377004678866 no 3208 0.0402122002844964 4560 4911358
SGTC_2952 9073731 13.78 µM -1.75021795525946 0.0344665942155622 no 3209 0.0400403558543397 4584 16457353
SGTC_1548 st061468 90.8 µM -1.75522279364957 0.0340391306698083 no 3210 0.0396106032624685 4653 390799
SGTC_850 0388-0143 75.9 µM -1.75525113819103 0.0340367222327859 no 3211 0.0396081801144379 4612 67273
SGTC_600 1495-0418 41.6 µM -1.75539475662845 0.0340245211211283 no 3212 0.0395959041629322 4603 5377768
SGTC_2046 4110841 106 µM -1.75647144337978 0.033933165653864 no 3213 0.039503971643504 4617 44119630 YMR134W ERG29
SGTC_3084 9116877 49.47 µM -1.76343537841927 0.0333471458588282 no 3214 0.0389135436577179 4573 27241325
SGTC_1061 3448-9325 110 µM -1.7639591348983 0.0333034104553882 no 3215 0.0388694297841668 4578 723482
SGTC_2887 9044784 58.44 µM -1.76404241733065 0.0332964604508859 no 3216 0.0388624189988062 4535 6465546
SGTC_1043 0916-0009 19.3 µM -1.76531855401591 0.0331901148341826 no 3217 0.0387551214741207 4621 3101130
SGTC_603 3794-0023 45.9 µM -1.76686199479129 0.0330618676912369 no 3218 0.0386256716016122 4658 3802260
SGTC_938 3126-1755 342 µM -1.76848657705727 0.0329273197237039 no 3219 0.0384897971234971 4606 1777771
SGTC_1516 st013856 110 µM -1.77357922197033 0.0325084684986458 no 3220 0.0380663885473592 4626 5281404 A mutagen and neurotoxin.
SGTC_1217 1183-1422 255 µM -1.77384705284316 0.0324865626091823 no 3221 0.0380442263495503 4635 2849664
SGTC_2675 theaflavin digallate 100 µM -1.77430140884963 0.0324494286793244 no 3222 0.0380066538329001 4570 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2102 5377816 72.7585 µM -1.77608472262688 0.0323040190457998 no 3223 0.0378594769532044 4641 1379702
SGTC_2534 helenine 20.12 µM -1.7800901606991 0.0319793792800727 no 3224 0.0375306032910107 4623 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2 0422-0095 29 µM -1.78036191826928 0.0319574513445667 no 3225 0.0375083749192447 4559 6790840
SGTC_425 3825-7017 13.1 µM -1.78308430977488 0.0317384679222763 no 3226 0.0372862900697495 4610 3397440
SGTC_1235 benzylparaben 21.5 µM -1.78552308362679 0.0315433522863214 no 3227 0.0370882552566038 4655 7180
SGTC_1900 st060200 72.8 µM -1.7856303935153 0.0315347897144333 no 3228 0.0370795611958015 4615 688945
SGTC_3056 9094900 49.47 µM -1.79303851913788 0.0309483014705123 no 3229 0.0364833825657722 4610 25236784
SGTC_1859 st055998 20 µM -1.80322782806743 0.0301564054546022 no 3230 0.0356762208995237 4563 676301
SGTC_1553 gossypol 38.6 µM -1.80830725258085 0.0297679589064718 no 3231 0.035279346863094 4602 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_846 0335-0850 148 µM -1.81155143028402 0.0295220411859913 no 3232 0.0350277677394261 4626 6819598
SGTC_2281 7943571 200 µM -1.81422014393843 0.0293210116092163 no 3233 0.0348219200415385 4690 1244024
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.81645162912194 0.0291537915927266 no 3234 0.0346505607629216 4625 641818 YHR062C RPP1
SGTC_76 0433-0009 400.328 µM -1.81732004189327 0.0290889301606614 no 3235 0.0345840614500999 4672 2841569
SGTC_1810 st050138 53 µM -1.82388741520849 0.0286022874776288 no 3236 0.0340845473181599 4642 3444541
SGTC_2164 5685496 200 µM -1.8286637568221 0.0282526294826033 no 3237 0.033724997548745 4587 759046
SGTC_3200 9114385 49.47 µM -1.82946837679759 0.0281940778940341 no 3238 0.0336647362384491 4601 17018030 YLR208W SEC13
SGTC_1289 0976-0073 69.1 µM -1.83628326763398 0.0277022031930139 no 3239 0.0331578865594089 4674 3391136
SGTC_1385 3091-4834 14.1 µM -1.84150492710119 0.0273301793613741 no 3240 0.0327737996100165 4635 4072814
SGTC_1842 st055362 61.2 µM -1.84232180858485 0.0272723582356789 no 3241 0.0327140457896776 4622 676032
SGTC_1855 st056195 39.6 µM -1.84437653480965 0.0271273700387847 no 3242 0.0325641422979815 4582 4028379
SGTC_1203 3992-3522 103 µM -1.84844076225904 0.0268424787898658 no 3243 0.0322693032430917 4637 5322312
SGTC_1954 st077032 68.9 µM -1.85288564194813 0.0265337692148522 no 3244 0.0319493757454568 4591 698907
SGTC_884 0851-0618 334 µM -1.85960979653011 0.0260723994089668 no 3245 0.0314703761463486 4663 9642473
SGTC_1267 0828-0272 9.49 µM -1.87032511934588 0.0253510555637303 no 3246 0.0307193416778695 4687 745334
SGTC_398 bronopol 33.3 µM -1.87065387897301 0.0253291908537974 no 3247 0.0306965356960528 4580 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2781 5567276 71.43 µM -1.87767922167742 0.0248657214107154 no 3248 0.0302125304328455 4616 2853274
SGTC_1531 st059297 52.4 µM -1.88361337192505 0.0244797996799688 no 3249 0.0298086458858132 4665 7566702
SGTC_2081 5214970 32.255 µM -1.88636529315832 0.0243025447247838 no 3250 0.029622873079151 4618 2063512
SGTC_2227 7312221 64.1025 µM -1.89358054434142 0.023842911367834 no 3251 0.0291403539752092 4727 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_362 0310-0100 9.03 µM -1.89928466092992 0.0234847338395527 no 3252 0.0287635292798285 4663 790235
SGTC_636 0kpi-0074 126 µM -1.89945400756753 0.0234741696578779 no 3253 0.0287524041415183 4682 616434
SGTC_2105 5350118 200 µM -1.90875883612865 0.0228998299703041 no 3254 0.0281466046554126 4630 2133313
SGTC_2849 9019321 12.99 µM -1.90897646230562 0.0228865399669983 no 3255 0.0281325640653184 4661 16489627
SGTC_1561 5-methoxyflavone 52.9 µM -1.91211238321364 0.0226957557407903 no 3256 0.0279308904313171 4645 94525
SGTC_842 0271-0008 11.1 µM -1.91497555544063 0.0225227374556582 no 3257 0.0277478105488 4672 1221709
SGTC_2519 cryptotanshinone 88.04 µM -1.92040987331242 0.0221974056082774 no 3258 0.0274030736985089 4668 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_716 1683-5115 658 µM -1.92142086376562 0.0221373210470559 no 3259 0.0273393351567445 4654 723597
SGTC_1903 st060211 78.3 µM -1.92169378358075 0.0221211245929892 no 3260 0.0273221499621175 4676 688960
SGTC_776 4476-4378 112 µM -1.93584967009708 0.0212946483868569 no 3261 0.0264430577339157 4693 2892008
SGTC_1603 st002045 67.8 µM -1.93737935395227 0.0212069232816951 no 3262 0.0263494942467208 4667 5887985
SGTC_2970 9090938 41.86 µM -1.9523024291276 0.0203670309491405 no 3263 0.0254511546190942 4679 17217104
SGTC_778 3456-2434 196 µM -1.98127289615491 0.0188168539444606 no 3264 0.0237803391010616 4597 5539063
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -2.01493914231379 0.0171426307103595 no 3265 0.0219555130307061 4694 390807
SGTC_2185 6113692 200 µM -2.02493647091975 0.0166706622509933 no 3266 0.0214369440180675 4681 874150
SGTC_304 1310-0298 97 µM -2.02740025044164 0.0165560710374825 no 3267 0.0213107481788006 4445 1550234
SGTC_2437 5741531 144.16 µM -2.03191980195687 0.0163476173018267 no 3268 0.0210808877585011 4692 2262990
SGTC_1818 st052136 56.3 µM -2.0320286586405 0.0163426243886048 no 3269 0.021075377376111 4393 674169
SGTC_2664 lyso-paf C-16 73.48 µM -2.05197552844024 0.0154494972491091 no 3270 0.0200860203663906 4687 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2829 7992743 58.44 µM -2.0563901358982 0.0152575955079432 no 3271 0.0198724631636385 4655 16462845
SGTC_1650 st011916 45.8 µM -2.05687026549819 0.0152368483819336 no 3272 0.0198493534351849 4688 242528
SGTC_2582 agaric acid 100 µM -2.06094344926316 0.0150618127291571 no 3273 0.0196542177366013 4383 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_990 3985-0011 41.3 µM -2.06101637609274 0.0150586946796196 no 3274 0.0196507388963705 4684 5399565 YGL099W LSG1
SGTC_3217 9129673 49.47 µM -2.07791925079126 0.0143508024567263 no 3275 0.018858398560822 4660 17248312
SGTC_745 0469-0705 296 µM -2.08144287756275 0.0142068978416214 no 3276 0.0186966937377244 4724 3486736
SGTC_2273 7815444 169.05 µM -2.08921021321838 0.0138940650115264 no 3277 0.0183444022344769 4644 2824616
SGTC_1192 1488-0095 21.4 µM -2.0926783040832 0.0137563154954421 no 3278 0.0181889406355633 4727 915875
SGTC_2275 7947463 200 µM -2.09367207853412 0.0137170614477754 no 3279 0.0181446009245988 4666 1225414
SGTC_1172 0370-0043 85 µM -2.11025117125473 0.0130763020259964 no 3280 0.0174183635063042 4716 376585
SGTC_1898 st060199 18.6 µM -2.11220006685032 0.0130027067220144 no 3281 0.0173346463997037 4715 688866
SGTC_1892 st058411 7.36 µM -2.11345640204887 0.0129554543359196 no 3282 0.0172808614162788 4695 3934738
SGTC_1330 1469-0054 61.8 µM -2.11563592533793 0.012873831831624 no 3283 0.0171878919730431 4675 7102664
SGTC_1569 carminic acid 40.6 µM -2.11644561500843 0.0128436226952604 no 3284 0.017153463003678 4731 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_360 0957-0399 1.01 µM -2.12407958238576 0.0125618044380935 no 3285 0.0168317447509803 4709 6752301 YPR165W RHO1
SGTC_3091 9116372 49.47 µM -2.13003847603793 0.01234555913747 no 3286 0.016584218475908 4717 17169793
SGTC_2157 5649910 96.377 µM -2.13957268465717 0.0120062741024117 no 3287 0.0161946580366445 4700 2858091
SGTC_1736 st036774 51 µM -2.14375018422843 0.0118601795676016 no 3288 0.0160264543975535 4716 1272247
SGTC_2844 9010103 25.97 µM -2.16170263469109 0.0112497698637528 no 3289 0.0153205522177968 4665 2480525
SGTC_1969 st069479 40.1 µM -2.1717366188005 0.0109206430607394 no 3290 0.0149377673927325 4718 3895485
SGTC_1123 mangostin 811.285 nM -2.17469928032291 0.010825080460168 no 3291 0.014826329434628 4714 5281650 An antioxidant.
SGTC_462 ag-879 158 µM -2.18667997975935 0.0104460204343688 no 3292 0.0143829470586708 4718 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2811 7967822 32.47 µM -2.19755266671925 0.0101120833225371 no 3293 0.0139904997184488 4712 2232244
SGTC_2334 9017922 200 µM -2.21923467568683 0.00947386460286796 no 3294 0.0132353815751001 4712 3163164
SGTC_2738 aclarubicin 5.55 µM -2.21953193356644 0.00946536522766147 no 3295 0.0132252785954174 4764 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1280 0880-0253 10.1 µM -2.22557559404644 0.00929400139472847 no 3296 0.013021311232917 4732 6836607
SGTC_1555 citronellol 128 µM -2.22597827216264 0.00928268080834607 no 3297 0.0130078184149795 4738 8842 A terpine precursor.
SGTC_2078 5212016 200 µM -2.22939963570841 0.00918698099223361 no 3298 0.0128936632282309 4678 1899708
SGTC_3149 9097855 49.47 µM -2.23183802407806 0.00911930435588392 no 3299 0.0128128351130308 4704 25236625 YMR079W SEC14
SGTC_2593 nobiletin 86.24 µM -2.25771044223369 0.00842768187737588 no 3300 0.0119818588941303 4712 72344 An anti-infammatory.
SGTC_777 1315-0167 517 µM -2.29330370528589 0.00755161237617934 no 3301 0.0109152630326206 4750 4221767
SGTC_923 1900-2434 73.3 µM -2.31152574999151 0.00713495211633631 no 3302 0.0104019162686138 4708 5910570
SGTC_3355 9151058 44.0485 µM -2.31311763709294 0.00709953441082813 no 3303 0.010358086134852 4744 17015728
SGTC_611 3453-1652 23.7 µM -2.32177346873591 0.00690965371187641 no 3304 0.0101225682825532 4729 1560575
SGTC_2537 larixol 68.93 µM -2.32804161036403 0.00677496457333751 no 3305 0.00995494713760194 4727 6708759
SGTC_513 4245-1575 41.7 µM -2.34469192166838 0.00642838484644688 no 3306 0.00952140355486872 4607 719745
SGTC_2301 7769476 200 µM -2.34679115965542 0.00638582174126017 no 3307 0.0094679325094493 4727 977820
SGTC_3296 9122258 64.045 µM -2.35874975859044 0.00614807930938771 no 3308 0.00916830803155081 4712 4730474
SGTC_1224 0823-0416 294 µM -2.36113664193854 0.00610157683119619 no 3309 0.0091095081198793 4759 3598164
SGTC_324 1315-0088 19.6 µM -2.36251962189254 0.00607477575305023 no 3310 0.00907559026371312 4756 6787421
SGTC_1147 3809-1045 12.3 µM -2.37306242776862 0.00587387036834137 no 3311 0.00882064098191886 4752 325925
SGTC_2291 7917025 104.35 µM -2.38288513187037 0.00569201379606468 no 3312 0.00858877668782025 4691 2964612
SGTC_315 k915-0449 187 µM -2.42568096219583 0.00495671026457755 no 3313 0.00763984796596802 4761 20970215 YNL149C PGA2
SGTC_3294 9122953 26.2835 µM -2.4313158473848 0.00486648413103795 no 3314 0.00752204684972778 4735 16459826
SGTC_1783 st039459 87.517 µM -2.44097898933635 0.00471516033239318 no 3315 0.00732375346550176 4770 729761
SGTC_1234 0326-0494 15.5 µM -2.45590969288241 0.00448959169364379 no 3316 0.00702642334814784 4775 1547813
SGTC_2048 5246248 200 µM -2.45857468859082 0.00445035894090733 no 3317 0.00697448792460204 4769 677046
SGTC_3008 9078912 71.4286 µM -2.48015629513762 0.00414375996117361 no 3318 0.00656624021967258 4760 16648731
SGTC_1779 st039427 55 µM -2.5073611527763 0.0037842710394665 no 3319 0.00608181797578919 4749 1124498
SGTC_536 3852-0578 10.6 µM -2.52376452616011 0.00358127596145001 no 3320 0.00580528355888214 4763 2869208
SGTC_1320 1313-0481 95.3 µM -2.55048407024279 0.00327147443428872 no 3321 0.00537867199893646 4742 6813365 YLR208W SEC13
SGTC_2742 clothiapine 36.27 µM -2.55865329467408 0.00318168862156846 no 3322 0.0052539240229416 4772 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_51 1013-0126 23.419 µM -2.58293875616159 0.00292771938830959 no 3323 0.00489813555923856 4758 1627850
SGTC_875 0709-0210 25.7 µM -2.61530114371718 0.00261770882992624 no 3324 0.00445744079533909 4768 6251364
SGTC_2724 maprotiline 69.64 µM -2.63427212836341 0.00245007929472335 no 3325 0.00421589398020959 4747 4011 A tricyclic antidepressant.
SGTC_1634 st006576 41 µM -2.65143610356568 0.0023068490651225 no 3326 0.00400751384409304 4756 3915356
SGTC_2080 5212524 12.4 µM -2.65196379953504 0.00230256822267188 no 3327 0.0040012560638873 4753 260183
SGTC_3160 9100216 49.47 µM -2.71771888943168 0.00182216082748165 no 3328 0.00328668298953684 4786 17191039
SGTC_2937 9044753 11.33 µM -2.74667649105448 0.00164109622429019 no 3329 0.00301012424877769 4753 6465530 YGL099W LSG1
SGTC_2160 5660466 132.927 µM -2.78634760941952 0.00141961605656243 no 3330 0.0026652837654193 4782 2859134
SGTC_2723 salbutamol 83.58 µM -2.89262356959729 0.000953966861576771 yes 3331 0.00191019434058662 4792 9884233 β2-adrenoceptor agonist
SGTC_2662 daunorubicin 22.37 µM -2.93347106609018 0.000815905869672004 yes 3332 0.00167597447537179 4707 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2596 sinensetin 100 µM -2.95490222861422 0.000751063089466459 yes 3333 0.00156384076124321 4759 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2279 7948423 32.93 µM -2.96354786423825 0.000726275473337242 yes 3334 0.00152057380933393 4771 1247112
SGTC_2162 5663267 200 µM -2.96571283330568 0.000720187536856986 yes 3335 0.00150991157722073 4791 6456493
SGTC_3197 9113331 49.47 µM -2.98143897896837 0.000677357642951091 yes 3336 0.00143448608014444 4753 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_892 0929-0076 29 µM -2.99194084696617 0.0006500779094686 yes 3337 0.00138604985583237 4790 5751038
SGTC_2271 7849410 118.62 µM -3.02562247428799 0.000569279416589022 yes 3338 0.001240609467062 4766 972430
SGTC_299 1273-0059 1.44 µM -3.06608608400356 0.000484514466662632 yes 3339 0.00108440431611612 4652 2848077
SGTC_292 k038-0015 474 µM -3.07191336628906 0.000473318646891404 yes 3340 0.00106345722616565 4796 46368540
SGTC_310 1273-0058 1.06 µM -3.07206944517971 0.000473022098259982 yes 3341 0.00106290131264455 4510 2734232
SGTC_627 1391-0720 175 µM -3.07852834915156 0.000460900104234081 yes 3342 0.00104012868135617 4788 997839
SGTC_2840 9008771 71.43 µM -3.19963025149175 0.000280687057876503 yes 3343 0.000688019972658528 4790 2992978
SGTC_2804 7954240 19.48 µM -3.3977825860544 0.000120063434157436 yes 3344 0.000339671929165211 4786 828705
SGTC_2806 7952793 58.44 µM -3.40899689988358 0.000114268868569687 yes 3345 0.000326011103286927 4784 2972490
SGTC_1968 st069590 43.6 µM -3.45828302909018 9.17773967136728e-05 yes 3346 0.000271814977083521 4795 6384066
SGTC_1240 0356-0016 42.1 µM -3.52666283537569 6.73857119283095e-05 yes 3347 0.000210416148967801 4790 4305613
SGTC_2938 9059746 27.26 µM -3.83316850833367 1.57440784898001e-05 yes 3348 6.32516168780294e-05 4793 6471769
SGTC_2896 9052656 71.43 µM -3.83708935306916 1.54426008022917e-05 yes 3349 6.22505906585927e-05 4609 6469436
SGTC_128 0906-2981 13.371 µM -4.14610548220085 3.17302065614152e-06 yes 3350 1.69089040373584e-05 4804 6740226
SGTC_3152 9099253 49.47 µM -6.16740014849907 5.65664068947955e-12 yes 3351 3.47109612322376e-10 4799 25236131