SGTCid condition conc unit STD1|YOR047C.score STD1|YOR047C.strain.pval STD1|YOR047C.strain.significant STD1|YOR047C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_457 grayanotoxin iii 135 µM 14.8726206321051 1.64856125729391e-52 yes 1 2.48159374586244e-50 1 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1233 0325-0408 14.2 µM 6.40316093675011 3.40206918517288e-11 yes 2 7.60963085884595e-11 3 12874
SGTC_899 1083-0020 478 µM 4.63311823638408 1.23290385782178e-06 yes 3 1.80099338946432e-06 13 767123
SGTC_3188 9110789 49.47 µM 4.57034394799575 1.68721709106941e-06 yes 4 2.43462196560992e-06 11 849217
SGTC_2863 9028737 58.44 µM 4.42573141468797 3.42329841522045e-06 yes 5 4.80580271700918e-06 2 6460917
SGTC_495 decylubiquinone 155 µM 4.35743557658634 4.74648073832778e-06 yes 6 6.57976075306406e-06 16 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_389 tpck 16.7 µM 4.31586763773344 5.77769655259588e-06 yes 7 7.94886115659792e-06 23 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1409 3909-8004 61.9 µM 4.25032241387657 7.84968591188319e-06 yes 8 1.06731511606163e-05 8 2119279
SGTC_1182 1222-0449 220 µM 3.91374891261772 3.53804765708892e-05 yes 9 4.5437065590807e-05 18 658318
SGTC_2698 st077697 67.5 µM 3.6124605903284 0.000123695288174156 yes 10 0.000151652606928784 23 3154499
SGTC_2985 9022375 71.43 µM 3.59871366577847 0.000130682819752808 yes 11 0.000159897525625736 44 4939335
SGTC_1069 diphenylcyclopropenone 8.49 µM 3.57530832614463 0.000143437808284104 yes 12 0.000174907693470193 42 65057 A dermal irritant. YDR527W RBA50
SGTC_2760 etidronate 98.04 µM 3.4623769291048 0.000223096819534471 yes 13 0.000267713362522371 44 3305 A chelator and antioxidant.
SGTC_2521 angolensin 13.4 µM 3.44037020016067 0.000242792653252624 yes 14 0.000290459502274175 19 821428 A flavenoid.
SGTC_432 NS 1619 61.3 µM 3.36485288369326 0.000323396653877262 yes 15 0.000382922408530956 48 4552 A K+/calcium channel activator.
SGTC_2862 9027634 71.43 µM 3.35487576913155 0.000335738331317543 yes 16 0.000397003166738237 51 5012562
SGTC_266 formosanin C 406 nM 3.33956688757283 0.000355529400270732 yes 17 0.000419545707573527 89 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2584 androsterone 48.74 µM 3.29138040120601 0.00042512367070941 yes 18 0.000498484995446275 176 2754130 A steroid.
SGTC_1773 st048542 73.5835 µM 3.2774350522531 0.000447506051069044 yes 19 0.000523774135011273 76 3237138
SGTC_1891 st059073 26.2 µM 3.27254817956866 0.000455604564771102 yes 20 0.000532913527785937 42 688754
SGTC_1275 0867-0008 21.1 µM 3.26445192264171 0.000469321164799325 yes 21 0.000548380373507072 30 3422836
SGTC_2876 9059903 25.97 µM 3.22644989312351 0.000538965492171943 yes 22 0.000626680876941217 34 6916095
SGTC_1286 0929-0070 131 µM 3.2244368902089 0.00054290870176669 yes 23 0.00063110336917771 46 1420408
SGTC_461 N-acetylfarnesylcysteine 136 µM 3.1827770341462 0.000630748725873561 yes 24 0.000729349478099663 8 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2965 9082772 38.63 µM 3.17289604303849 0.000653424221194332 yes 25 0.000754632776807376 73 16459634
SGTC_416 estradiol valerate 100 µM 3.16664464426128 0.000668156382773869 yes 26 0.000771043167372839 37 13791 A steroid.
SGTC_27 0485-0001 32.618 µM 3.16354346909744 0.000675577835903147 yes 27 0.000779305370631884 14 2054479
SGTC_993 3909-8757 62.7 µM 3.15914443445314 0.000686235704904391 yes 28 0.000791165251218428 56 4288324 YLR208W SEC13
SGTC_664 1222-0054 14.9 µM 3.14053647056621 0.000733056184760952 yes 29 0.0008431935444138 67 6813991
SGTC_397 arbidol 50 µM 3.13308913383351 0.000752606322422558 yes 30 0.000864884521647904 53 131410 A RNA synthesis inhibitor.
SGTC_1554 st069299 38.7 µM 3.13015398943776 0.000760442523991904 yes 31 0.00087357345123774 48 24207999
SGTC_1220 1838-0075 193 µM 3.07301440326531 0.000928773595271638 yes 32 0.00105954129772121 42 5529645
SGTC_2852 9023854 51.95 µM 3.04272908092792 0.00103127736872641 no 33 0.00117221648489593 60 19798528
SGTC_539 4859-0462 2.54 µM 2.98247479779787 0.00126669694197913 no 34 0.00142964094126191 64 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1232 0279-0259 161 µM 2.96994063196328 0.00132146242340872 no 35 0.0014892865294356 70 1560000
SGTC_322 k048-0136 19.3 µM 2.96493187540701 0.00134394601906846 no 36 0.0015137498196981 50 6823282
SGTC_1648 st011736 69.8 µM 2.96277906931213 0.00135371663814928 no 37 0.00152437653104793 48 2855514
SGTC_599 1935-0052 86.5 µM 2.95039221253159 0.00141120717262075 no 38 0.00158685380561758 58 9557311
SGTC_712 r015-0009 80.6 µM 2.94531150490123 0.00143542617373971 no 39 0.00161314831833285 63 6813872 YLR060W FRS1
SGTC_2418 pentamidine 31.67 µM 2.92829485213209 0.00151933169472929 no 40 0.00170413332423714 94 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_386 1509-0011 3.07 µM 2.91834576677259 0.00157043715070587 no 41 0.0017594695446445 209 3107280
SGTC_3204 9114183 49.47 µM 2.90366055542823 0.001648737971782 no 42 0.00184413902045681 82 17027248
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.89689018078708 0.00168602126359408 no 43 0.0018844082933788 30 88881 An O-methylated flavonoid and antioxidant.
SGTC_364 0083-0097 67.7 µM 2.87503663727965 0.00181166317248825 no 44 0.00201990309256803 82 5207356
SGTC_1654 st012436 41.8 µM 2.86474053058891 0.00187375972380036 no 45 0.00208675529834982 54 4323132
SGTC_2705 st078069 42.8 µM 2.83004128200805 0.00209754353696945 no 46 0.00232709992080877 52 1530061
SGTC_2536 dehydroabietamide 32.04 µM 2.81926685181604 0.00217180904473971 no 47 0.00240667420315851 111 3983547
SGTC_2356 9061756 188.97 µM 2.81247045283339 0.00221987285034537 no 48 0.00245812700192725 42 20104043
SGTC_2393 9031399 185.94 µM 2.8077572667058 0.0022537681256104 no 49 0.00249439070466424 91 1526623 YDL150W RPC53
SGTC_2954 9074818 52.69 µM 2.79527496500663 0.00234581268539718 no 50 0.00259277947831565 93 16648742
SGTC_2007 4011539 71.82 µM 2.78389878977876 0.00243265066612505 no 51 0.00268548955032322 124 45595301
SGTC_1142 3253-1408 9.78 µM 2.77149932682781 0.00253060334693941 no 52 0.00278993938425069 56 256655
SGTC_2858 9025781 8.96 µM 2.73818760761377 0.0028116593639826 no 53 0.00308894111635171 195 4894980 YPL153C RAD53
SGTC_1608 st001473 40.5 µM 2.73186045345487 0.00286812095807754 no 54 0.0031488904572076 99 7292267
SGTC_2032 5185112 25.99 µM 2.73023075423845 0.00288282853417999 no 55 0.00316450039709084 69 5718189
SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.70539377576353 0.00311554899509674 no 56 0.00341117319273715 69 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2667 digitoxin 100 µM 2.70292507889824 0.00313958065903548 no 57 0.0034366118427377 36 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1860 st056228 74.6 µM 2.66442477161419 0.00353658028393498 no 58 0.00385600567291437 88 688679
SGTC_2311 7694451 200 µM 2.65431688492544 0.00364801807163608 no 59 0.00397345793532917 97 2163142
SGTC_403 arphamenine a 50 µM 2.61563630219122 0.00410413580636761 no 60 0.00445306833153168 96 5487158 An arginine aminopeptidase inhibitor.
SGTC_305 1682-2595 20.8 µM 2.61128852609671 0.00415847030896465 no 61 0.00451008780871652 93 226033
SGTC_2289 7946404 165.07 µM 2.57924156516902 0.00457921976434503 no 62 0.00495087587151516 199 1246120 YPR165W RHO1
SGTC_1936 st074407 74.3 µM 2.5767571983505 0.00461337230612357 no 63 0.00498659890288849 151 809813
SGTC_1902 st060212 70.5 µM 2.56811670830667 0.00473392996880031 no 64 0.00511263616318881 107 688944
SGTC_620 0109-0052 432 µM 2.55108301622775 0.00497985386655025 no 65 0.00536943714658517 97 493037
SGTC_793 0488-0545 106 µM 2.54809886980074 0.00502409013478937 no 66 0.0054155884659975 105 292548
SGTC_1640 st009078 66.4 µM 2.53799235178216 0.00517651768052298 no 67 0.00557452104608735 83 690618
SGTC_2035 5154463 94.595 µM 2.53029479850774 0.00529535980504697 no 68 0.00569833633179003 123 2769623
SGTC_1311 1190-0148 100 µM 2.52597795375088 0.00536306403169424 no 69 0.00576883606453397 134 1961333
SGTC_268 camptothecin 39.6153 µM 2.51735371561947 0.0055006330659253 no 70 0.00591200290810644 223 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1372 2752-0194 270 µM 2.50731706587883 0.00566467272535234 no 71 0.00608257667444484 94 823334
SGTC_2351 9026858 72.31 µM 2.50472624403037 0.00570771641033611 no 72 0.00612731010442469 119 1409300
SGTC_1221 2958-7315 257 µM 2.49748942755877 0.00582949026056456 no 73 0.00625380973739813 104 4562705
SGTC_65 0798-0905 34.986 µM 2.4551092945509 0.00658998031232852 no 74 0.00704208801539418 237 3602145
SGTC_3218 9131285 49.47 µM 2.4452607580252 0.00677879743421839 no 75 0.0072373723266065 182 17156417
SGTC_1859 st055998 20 µM 2.42862807651303 0.00710854943987313 no 76 0.0075780354739984 117 676301
SGTC_910 3454-3003 490 µM 2.42602665506261 0.00716138416989501 no 77 0.00763257452963228 130 820824
SGTC_398 bronopol 33.3 µM 2.4127806673367 0.00743581719289479 no 78 0.00791567161118353 129 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_284 0988-0104 32.6 µM 2.40767439519888 0.00754405950283381 no 79 0.00802724618707173 100 4666532
SGTC_69 0096-0274 206.684 µM 2.39125358517516 0.00790161099455076 no 80 0.00839547551173817 196 6741392
SGTC_907 3448-6986 75.5 µM 2.38023118881195 0.00814989785934914 no 81 0.00865088966640176 156 590582
SGTC_556 4058-0063 51.5 µM 2.37822556645974 0.00819580573158823 no 82 0.00869809033714552 126 6615692
SGTC_3151 9099821 49.47 µM 2.37256869470958 0.00832651543969656 no 83 0.00883243897778058 131 17174189
SGTC_939 1165-0479 45.3 µM 2.3564606310357 0.00870879302389452 no 84 0.00922501161326117 180 1377347
SGTC_1216 1165-0504 9.65 µM 2.34983037115112 0.00887056037262253 no 85 0.00939098412515904 126 6304004
SGTC_1369 1866-0067 208 µM 2.34307964269607 0.00903796643689691 no 86 0.00956265002932502 169 3531355
SGTC_1941 st076221 61.8 µM 2.32733928215323 0.00943908566217063 no 87 0.0099736073015662 241 2828568
SGTC_1969 st069479 40.1 µM 2.32509972908219 0.00949740431960676 no 88 0.0100333140705694 110 3895485
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.32155107183158 0.00959045762707384 no 89 0.0101285605343659 104 61125 An anti-inflammatory.
SGTC_2367 9070478 135.38 µM 2.3180491300361 0.00968306622397983 no 90 0.0102233255534202 168 572802
SGTC_1396 3511-0007 98.6 µM 2.31797783109483 0.00968495980794494 no 91 0.0102252629589031 132 X1396
SGTC_520 3584-0023 682 µM 2.31634681415538 0.00972836541738636 no 92 0.0102696701014596 144 1340790
SGTC_3125 9127534 49.47 µM 2.31289559194489 0.00982077208223538 no 93 0.0103641901233345 93 1639235
SGTC_1120 ficusin 1.78878 µM 2.31282938247741 0.00982255231345567 no 94 0.0103660108186895 142 6199 A DNA cross-linker.
SGTC_2745 rifampicin 24.3 µM 2.30357150501421 0.010074268443857 no 95 0.0106233544718374 56 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_602 3130-1533 38.1 µM 2.29570968779778 0.010292427939276 no 96 0.0108462430798644 168 720941
SGTC_667 1498-1044 59 µM 2.28951575514558 0.0104671950731774 no 97 0.0110247017817246 155 6739982
SGTC_1950 st077106 7.18 µM 2.28278512142198 0.010660032353911 no 98 0.0112215144026848 168 13831864
SGTC_2533 agelasine 13.65 µM 2.28020077358559 0.0107348936724464 no 99 0.0112978917437858 197 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2717 st081029 62.2815 µM 2.2607028350057 0.011314595443938 no 100 0.0118888324047579 114 5292846
SGTC_792 4534-1957 155 µM 2.25203430776446 0.0115809394312089 no 101 0.0121600520246416 175 1717904
SGTC_3149 9097855 49.47 µM 2.24758512596155 0.0117197444622616 no 102 0.0123013284492681 153 25236625 YMR079W SEC14
SGTC_2879 9041815 71.43 µM 2.24124936080325 0.0119198981179078 no 103 0.0125049635574001 66 4942971
SGTC_2935 9038016 29.96 µM 2.23148574875586 0.0122341456828562 no 104 0.0128244852406564 164 6463195
SGTC_2 0422-0095 29 µM 2.22748883733518 0.0123648450115414 no 105 0.0129573105115576 84 6790840
SGTC_2347 9049783 174.81 µM 2.21851749550216 0.0126626199129545 no 106 0.0132597840149679 214 6467988 YPL169C MEX67
SGTC_3021 9087658 49.47 µM 2.21208982525215 0.012879763648848 no 107 0.013480229507776 91 25237042
SGTC_716 1683-5115 658 µM 2.20418236139014 0.0131513104085253 no 108 0.0137557608663726 172 723597
SGTC_2645 abamectin 100 µM 2.19740174404975 0.0133880867462626 no 109 0.0139958834192531 169 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1615 st002656 86.5 µM 2.19119438750485 0.0136080635795938 no 110 0.0142188642925842 155 1584458
SGTC_1451 4152-0210 104 µM 2.18455458488722 0.0138468113070331 no 111 0.0144607604554583 189 659563
SGTC_2461 5755302 26.15 µM 2.18302639327715 0.0139022691541489 no 112 0.0145169332043738 207 2788904
SGTC_1540 guanosine 70.6 µM 2.18128543920054 0.0139656813887027 no 113 0.014581155361794 129 6802 Guanosine is a purine nucleoside
SGTC_3060 1327-0027 12.5 µM 2.1773779002178 0.014108917475233 no 114 0.0147261915996668 161 16000455 YPR107C YTH1
SGTC_25 0118-0223 35.662 µM 2.1691444138175 0.0144148757146628 no 115 0.0150358608456637 170 5333628
SGTC_1511 0906-3109 28.5 µM 2.1601475810657 0.0147557147942272 no 116 0.0153806232952547 265 2882180
SGTC_513 4245-1575 41.7 µM 2.15701842466664 0.014875874664845 no 117 0.0155021144422407 347 719745
SGTC_362 0310-0100 9.03 µM 2.14632945484188 0.0152926986020746 no 118 0.0159233516045071 215 790235
SGTC_2445 5742597 35.57 µM 2.13714664042294 0.0156587607530938 no 119 0.0162930332270724 179 1774255
SGTC_2415 st077333 57.7 µM 2.13571400503453 0.0157165437147113 no 120 0.0163513660809383 272 2766255
SGTC_763 3453-1109 128 µM 2.13558000924375 0.0157219575539428 no 121 0.0163568311446913 186 1560353
SGTC_3042 9091578 49.47 µM 2.13169304911455 0.0158797003617705 no 122 0.0165160443084793 109 25236497
SGTC_2382 9035899 200 µM 2.1306596344622 0.0159218666415553 no 123 0.0165585964047149 179 6462679
SGTC_2033 5192550 145 µM 2.13026136005671 0.0159381429870068 no 124 0.016575020865809 168 182073
SGTC_96 0929-0093 37.281 µM 2.12612897910986 0.0161078651975344 no 125 0.0167462607933755 167 6991579
SGTC_1830 st055982 50.3 µM 2.11306285643085 0.0166547346940779 no 126 0.0172976941486944 190 455313 An antimicrobial agent.
SGTC_1419 3993-2473 62.6 µM 2.10343541423341 0.017067777807102 no 127 0.0177138627307849 185 704026
SGTC_1837 st055472 66.5 µM 2.10159961448787 0.0171475245770525 no 128 0.0177941818341179 199 676091
SGTC_1138 3761-0006 1.03 µM 2.09028360036686 0.0176461530785873 no 129 0.0182961657801917 136 12061087
SGTC_618 k072-0232 33.2 µM 2.08255119105925 0.0179939460594438 no 130 0.0186460760751359 161 5872756 YGL099W LSG1
SGTC_1641 st009299 47.1 µM 2.06856004537243 0.0186381123201545 no 131 0.0192936952577035 128 4046054
SGTC_3009 9080819 71.4286 µM 2.05841381283265 0.0191174438850849 no 132 0.0197752134559534 205 17027216
SGTC_1383 3049-0032 20.7 µM 2.05409190916772 0.0193247814736917 no 133 0.0199833984986156 205 712864
SGTC_1283 0922-0125 16.4 µM 2.05248576473051 0.0194023196285262 no 134 0.0200612385513201 197 3360884
SGTC_2296 7971656 126.45 µM 2.03434901180557 0.0202963864088633 no 135 0.0209582094198067 243 666570
SGTC_1414 3917-0015 5.4 µM 2.03348488908611 0.0203398417080537 no 136 0.0210017793517823 163 6618702
SGTC_2384 9036245 200 µM 2.0332135730131 0.0203535020010645 no 137 0.0210154751815645 191 6462766
SGTC_1727 st034309 9.9045 µM 2.0301860917863 0.0205064586386525 no 138 0.0211688135183265 288 870305
SGTC_1904 st060225 78 µM 2.02693078603973 0.020672011098798 no 139 0.0213347457818079 178 66595
SGTC_1828 st055811 49 µM 2.02571766702938 0.0207339945637197 no 140 0.0213968625976178 146 5877589
SGTC_1379 2144-0755 36.5 µM 2.02492669236962 0.020774493562984 no 141 0.0214374461354967 244 5392327
SGTC_807 1315-0151 48 µM 2.02261947543127 0.0208930091019655 no 142 0.0215561973528718 246 4011080
SGTC_2742 clothiapine 36.27 µM 2.00432823236037 0.0218529886260856 no 143 0.0225174557573674 158 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_953 1188-0045 9.7 µM 1.99700003841176 0.0222479130325667 no 144 0.0229125894092999 248 6144426
SGTC_1689 st020265 53.493 µM 1.99102046811494 0.0225746044326486 no 145 0.0232393185275804 201 5758320 YPR016C TIF6
SGTC_1153 4055-0057 267 µM 1.98574862021143 0.0228659755234564 no 146 0.0235306217031725 245 882706
SGTC_946 3434-1334 87.4 µM 1.98374199331289 0.0229777097444265 no 147 0.0236423048063538 218 4047976
SGTC_2552 juarezic acid 87.02 µM 1.98257759112638 0.0230427572981217 no 148 0.0237073162520102 266 1549512
SGTC_1603 st002045 67.8 µM 1.97618008855464 0.0234029168459253 no 149 0.0240671921042433 194 5887985
SGTC_450 aminopyrene 156 nM 1.97355326242793 0.0235521647735705 no 150 0.0242162812928462 262 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1003 4049-0218 100 µM 1.96607328780768 0.0239815453372029 no 151 0.0246450727512033 270 295161
SGTC_2378 9074213 121.43 µM 1.96294421809566 0.0241631080673699 no 152 0.0248263280151568 249 657714
SGTC_3014 9081533 49.47 µM 1.95842989207789 0.0244270830937976 no 153 0.0250897950345208 210 21367265
SGTC_695 3505-6186 243 µM 1.94979353746265 0.0249388415894408 no 154 0.0256003660729334 221 1819379
SGTC_2983 9022671 12.99 µM 1.94622487738062 0.0251529166960456 no 155 0.0258138664269557 215 6405161
SGTC_3353 9151644 39.2805 µM 1.94335164224718 0.0253263921965492 no 156 0.025986842907417 229 4909158
SGTC_634 1611-4317 11.2 µM 1.94152305695199 0.0254373166184453 no 157 0.0260974327569733 254 2843522
SGTC_2620 irigenin 100 µM 1.9411113819794 0.0254623454079283 no 158 0.0261223843919346 266 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1086 cerivastatin 2.18 µM 1.93495518840981 0.0258390931848229 no 159 0.0264978974516113 184 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2504 purpurogallin 52.29 µM 1.93488782199555 0.0258432415491648 no 160 0.0265020314597941 224 5281571 An antioxidant.
SGTC_936 3005-4620 401 µM 1.93230588672487 0.0260026553533289 no 161 0.0266608811374679 270 777207
SGTC_1217 1183-1422 255 µM 1.92724424502316 0.0263175585294249 no 162 0.0269745991800416 248 2849664
SGTC_2856 9022925 19.48 µM 1.92529900879029 0.0264394237664553 no 163 0.0270959807930222 258 4944862
SGTC_1338 1486-1223 76 µM 1.91405388246543 0.0271531862857426 no 164 0.0278066356542115 246 3444526
SGTC_185 k048-0037 25.491 µM 1.91174450709312 0.0273017419543773 no 165 0.0279544863213231 209 6827589
SGTC_2140 5586273 200 µM 1.90588462136377 0.0276817369037435 no 166 0.0283325883631339 187 854421
SGTC_532 1548-0774 215 µM 1.89885856164634 0.0281431551389186 no 167 0.0287915374811958 260 5932993
SGTC_1804 st050076 49.1 µM 1.89442574915262 0.0284375498313352 no 168 0.0290842606647668 249 3895976
SGTC_2941 9056145 11.23 µM 1.88630660669796 0.028983407691555 no 169 0.0296268247514307 173 2119517
SGTC_33 0986-0033 35.816 µM 1.88431895580533 0.0291183581038348 no 170 0.0297609224341883 200 2848082
SGTC_1194 1488-0194 225 µM 1.87850154010795 0.0295163310295917 no 171 0.0301562932866043 287 1391452
SGTC_2878 9043973 25.97 µM 1.87847400148605 0.0295182256473162 no 172 0.0301581752070449 214 6465167
SGTC_3025 9087895 49.47 µM 1.87478343667745 0.0297730460567584 no 173 0.0304112613744183 263 17173641
SGTC_359 0081-0058 15.9 µM 1.87196761119526 0.0299686939707038 no 174 0.0306055422862259 272 3494159
SGTC_2403 6032726 181.2 µM 1.8696265418405 0.0301321657209613 no 175 0.0307678484221856 278 2881040
SGTC_2946 9065502 71.43 µM 1.86919764583395 0.030162194567086 no 176 0.0307976608449581 140 16489101
SGTC_1871 st057448 67.3 µM 1.86886934201711 0.0301851972819787 no 177 0.0308204972923125 278 691747
SGTC_2707 st078556 66.6 µM 1.86109184606059 0.0307343968048128 no 178 0.0313656037514696 223 17250899
SGTC_2282 7944268 200 µM 1.8558351728546 0.0311102567378634 no 179 0.0317385277417223 301 2970414
SGTC_188 3229-0966 278.469 µM 1.84838015638972 0.031649814968377 no 180 0.0322736836542685 319 5722370
SGTC_2208 7283366 200 µM 1.84285710845255 0.0320545140330892 no 181 0.0326749380407628 253 898663
SGTC_1066 ketoconazole 628 nM 1.83887729690367 0.0323487740899975 no 182 0.0329666178806417 301 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_769 0302-0231 76 µM 1.833206870922 0.0327718823767794 no 183 0.0333859062432118 350 571869 YER009W NTF2
SGTC_2004 4023728 41.89 µM 1.8289435163773 0.0330929957529951 no 184 0.0337040351435062 301 360084 YDR527W RBA50
SGTC_159 3970-0959 50 µM 1.82872236395893 0.0331097233008411 no 185 0.0337206052233455 501 6615653
SGTC_2514 salinomycin 42.74 µM 1.82256343167152 0.0335783787237646 no 186 0.0341847691919693 352 23682228 A polyether potassium ionophore.
SGTC_1703 st026983 48.3 µM 1.8202652298922 0.0337546502015127 no 187 0.034359311847431 272 1104023
SGTC_411 enrofloxacin 100 µM 1.81712809917881 0.0339964956110968 no 188 0.0345987505655565 250 71188 A bacterial gyrase inhibitor.
SGTC_1362 1611-0397 101 µM 1.80573688907917 0.034886667922442 no 189 0.0354797238078363 273 27816
SGTC_2078 5212016 200 µM 1.79650084577709 0.0356223915448291 no 190 0.0362074491606365 233 1899708
SGTC_2221 6807166 181.081 µM 1.79479563543729 0.0357596060633079 no 191 0.0363431332325634 176 674925
SGTC_2483 5729050 27.16 µM 1.79469506310829 0.035767712404212 no 192 0.0363511487808686 369 2865180
SGTC_718 1130-0073 349 µM 1.79001734022049 0.0361464136628777 no 193 0.0367255619115433 307 6740020
SGTC_887 0885-0007 9.62 µM 1.78987892670433 0.0361576692286928 no 194 0.0367366886380412 316 5719458
SGTC_1717 st033143 58.0435 µM 1.78481496365697 0.0365714397538149 no 195 0.0371456676859625 331 674616
SGTC_1061 3448-9325 110 µM 1.7785558643369 0.0370882081827266 no 196 0.0376563027292809 236 723482
SGTC_1323 1348-1351 11.2 µM 1.77607101103735 0.0372950125705118 no 197 0.0378606067938472 249 6989654
SGTC_1675 st018485 24.5 µM 1.77478301687522 0.0374025773132476 no 198 0.0379668607932742 313 3323024
SGTC_2376 9072922 81.32 µM 1.77156338902679 0.0376725680024325 no 199 0.0382335307684661 326 17087968
SGTC_2955 9076254 12.21 µM 1.77073560540035 0.0377422405772565 no 200 0.038302339321638 264 16459619
SGTC_1583 clindamycin 39.6 µM 1.76789773272943 0.0379818963022473 no 201 0.0385390009600337 279 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3013 9080133 71.4286 µM 1.76596697242278 0.038145655813589 no 202 0.0387006950105742 335 17050193
SGTC_46 0329-0187a 2.197 µM 1.7656125000417 0.0381757832443732 no 203 0.0387304407293522 412 46494817
SGTC_990 3985-0011 41.3 µM 1.76305203703812 0.0383939797164383 no 204 0.0389458567738511 256 5399565 YGL099W LSG1
SGTC_408 cantharidin 100 µM 1.76271790008861 0.0384225289036271 no 205 0.038974040104962 337 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2123 5259487 200 µM 1.75473017058502 0.0391101799626319 no 206 0.0396527364009381 300 2173474
SGTC_983 1491-0821 12.2 µM 1.75004449764755 0.0395182026194021 no 207 0.0400553178755681 261 46495113
SGTC_1316 1272-0050 65.9 µM 1.74549710650334 0.0399174879081918 no 208 0.0404491878424249 265 7340392
SGTC_2932 9016711 44.54 µM 1.7431000709541 0.0401292765712367 no 209 0.0406580681167136 351 7117328
SGTC_1404 3909-7820 48.3 µM 1.73409685929202 0.0409329173567613 no 210 0.0414504493497624 282 23741373
SGTC_1921 5740136 50 µM 1.73255445436673 0.0410718958704452 no 211 0.0415874452316668 372 1774243
SGTC_2857 9024691 58.44 µM 1.73180257350468 0.0411397827547057 no 212 0.0416543598996276 296 16478292
SGTC_3257 9139206 32.98 µM 1.72820285381626 0.041466060899083 no 213 0.0419759311395631 217 4910041
SGTC_228 caffeine 993.056 µM 1.72533331358758 0.0417276549974331 no 214 0.0422337108117047 246 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2439 5492030 7.2 µM 1.72404824592132 0.0418452373456245 no 215 0.0423495669360925 286 5722370
SGTC_71 0417-1750 47.813 µM 1.71202885676215 0.042958036542997 no 216 0.04344567533926 360 6811472
SGTC_2750 bromebric acid 70.15 µM 1.70570932745105 0.0435526432366747 no 217 0.0440311060789119 379 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3026 9090633 49.47 µM 1.69992272267288 0.0441029162130165 no 218 0.0445727310972689 310 25236842
SGTC_606 k015-0008 38.6 µM 1.6924735550872 0.0448195271615024 no 219 0.0452778590751614 351 1970475
SGTC_3292 9120825 59.784 µM 1.68426368607891 0.045620146833329 no 220 0.0460653600524352 315 24824900
SGTC_171 k064-0041 9.68 µM 1.68330441521533 0.0457144397021128 no 221 0.0461580880686385 262 53325
SGTC_2909 7941780 10.49 µM 1.66488341087285 0.0475557328879809 no 222 0.0479680092385672 332 1243215
SGTC_2407 paclitaxel 400 µM 1.65563100857686 0.0485027291192629 no 223 0.0488982833025495 394 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1270 0831-1170 17.3 µM 1.65518926978897 0.0485483161623755 no 224 0.0489430555668044 357 6764716
SGTC_200 k038-0079 37.545 µM 1.65379898166486 0.0486920162598199 no 225 0.0490841814793776 336 3436683
SGTC_1791 st048313 56.1 µM 1.64921278934209 0.0491684568294899 no 226 0.0495520243697676 291 1204976
SGTC_2198 6589944 200 µM 1.6410800971411 0.0500224773425198 no 227 0.0503903948066311 266 5290268
SGTC_287 k060-0039 29.6 µM 1.64020774357482 0.0501147820552198 no 228 0.0504809899033411 323 5861974
SGTC_2201 6605497 169.863 µM 1.63238326414514 0.0509487829604818 no 229 0.0512993862450188 305 670741
SGTC_512 prima-1 270 µM 1.63015850228671 0.0511879239440554 no 230 0.051534000951352 361 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1206 3978-0017 132 µM 1.62810545786494 0.0514093984967704 no 231 0.0517512632357028 334 3873677
SGTC_758 0868-0029 16 µM 1.62712349484311 0.0515155980063413 no 232 0.0518554360027975 363 762687
SGTC_3058 9093861 49.47 µM 1.62616475154095 0.0516194545409918 no 233 0.0519573061916765 365 17217477
SGTC_3045 9092950 49.47 µM 1.62246583449399 0.0520217031692972 no 234 0.0523518213962943 379 44120432
SGTC_680 0417-1641 114 µM 1.62188657894761 0.0520849207889647 no 235 0.0524138178636415 329 2835990
SGTC_2149 5554786 194.827 µM 1.61777503411198 0.052535393826078 no 236 0.0528555443135929 405 745063 YPR165W RHO1
SGTC_1432 4049-0298 68.4 µM 1.61187285941888 0.0531874530964406 no 237 0.0534948046379576 325 741646
SGTC_3293 9120939 62.045 µM 1.61165324232421 0.0532118391666781 no 238 0.0535187089043974 340 934087
SGTC_3068 9116768 49.47 µM 1.61131197133222 0.0532497511555194 no 239 0.0535558714062469 346 41904888
SGTC_2482 5981709 142.65 µM 1.60819338172682 0.0535971896682185 no 240 0.0538964161084215 401 877755
SGTC_355 1311-2252 105 µM 1.6069899689517 0.0537317397514589 no 241 0.0540282842958616 391 5338538
SGTC_1930 st074634 34.3 µM 1.60578206867409 0.0538670604429633 no 242 0.0541609009100704 390 684253 YOR116C RPO31
SGTC_2073 5212005 126 µM 1.60570534492623 0.0538756648866509 no 243 0.0541693331826814 255 691789
SGTC_2425 5628681 7.85 µM 1.60402594607213 0.054064279493769 no 244 0.0543541667835055 439 5714958
SGTC_791 1348-1292 225 µM 1.60252151982837 0.0542336862536097 no 245 0.054520166346307 455 5437054
SGTC_2747 doxorubicin 7.63 µM 1.59941793351562 0.0545844942122216 no 246 0.0548638850696375 218 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1561 5-methoxyflavone 52.9 µM 1.59916304394683 0.0546133847214587 no 247 0.0548921897401028 272 94525
SGTC_1477 0139-0234 16 µM 1.58977813216893 0.055685562597905 no 248 0.055942412368231 352 620880
SGTC_2809 7964133 12.99 µM 1.58898481914336 0.055776950710294 no 249 0.0560319100433738 423 1253665
SGTC_3244 9134489 49.47 µM 1.58646964558991 0.0560674763677497 no 250 0.0563164062935181 366 16584271
SGTC_1145 3546-0597 10.2 µM 1.58142447132056 0.0566538373088436 no 251 0.0568905079027723 411 875334
SGTC_514 4466-0038 2.65 nM 1.58132201817226 0.0566657944909713 no 252 0.0569022138427365 512 5722064
SGTC_997 3996-0078 137 µM 1.56856109545172 0.0581707148469952 no 253 0.0583751217966411 402 735687
SGTC_2642 cholecalciferol 100 µM 1.56808031787425 0.0582280218474339 no 254 0.0584311946225009 342 9821465 A vitamin D precursor, similar to steriods.
SGTC_3012 9080433 71.4286 µM 1.56208441156998 0.0589464442226857 no 255 0.0591340523319752 390 17688859
SGTC_1355 1499-0035 1.68 µM 1.55251214004679 0.0601077743693671 no 256 0.0602698650933685 389 1548538
SGTC_1384 3089-0840 101 µM 1.55221700872417 0.0601438630336357 no 257 0.0603051538359034 350 1069836
SGTC_1471 k673-0312 37 µM 1.5517654051926 0.060199117958856 no 258 0.0603591832053791 380 24099884
SGTC_976 1348-1067 47.6 µM 1.549035628304 0.0605339601362039 no 259 0.0606865778084259 447 5310671 YGL099W LSG1
SGTC_2997 9067075 71.4286 µM 1.54849151663206 0.060600876256984 no 260 0.0607520013193061 440 27209819
SGTC_2834 9001755 58.44 µM 1.54204191817634 0.061398477998003 no 261 0.061531703799449 363 2989575
SGTC_516 3992-2719 87.3 µM 1.54203801467888 0.0613989632024327 no 262 0.0615321780548768 346 5350887 YDR037W KRS1
SGTC_2255 7941087 197.44 µM 1.54092771738473 0.0615370947001152 no 263 0.0616671895488503 449 935561
SGTC_2069 5228469 200 µM 1.53664817651888 0.0620717816914707 no 264 0.0621897440810626 366 2835210
SGTC_564 3555-0129 330 µM 1.53404480755858 0.0623988162743285 no 265 0.0625093149508811 305 563260
SGTC_1039 k821-0043 94 µM 1.53227759218267 0.062621577943789 no 266 0.0627269741130363 401 15992768
SGTC_3341 9147222 25.867 µM 1.5307306298189 0.0628170845690939 no 267 0.0629179902099835 382 1939759
SGTC_1445 4239-0156 97.7 µM 1.53035149647113 0.0628650723039769 no 268 0.0629648739765144 453 4008346
SGTC_41 0478-0632 82.643 µM 1.52947885201333 0.0629756333427246 no 269 0.0630728889107145 475 3750424
SGTC_1114 scopoletin 1.73284 µM 1.52745148537166 0.0632330783872479 no 270 0.0633243911312683 362 5280460 A coumarin with genotoxic properties.
SGTC_2417 cerulenin 830 nM 1.52123105580523 0.0640280953758191 no 271 0.0641009323249508 362 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1159 4092-0538 61.2 µM 1.51827226642486 0.0644089679151877 no 272 0.0644728880614615 451 717301
SGTC_1468 k284-1086 134 µM 1.51515624812734 0.0648119806483543 no 273 0.0648664199893881 492 15996457
SGTC_1177 0983-0204 23.6 µM 1.51399647739087 0.0649624795383032 no 274 0.0650133664612685 427 766818
SGTC_1425 4048-4433 7.33 µM 1.51290357935291 0.0651045487503858 no 275 0.0651520762964082 470 23734946
SGTC_3305 9127027 53.8275 µM 1.51142393889628 0.0652972758647222 no 276 0.0653402369935024 416 41905295
SGTC_2107 5363541 170.161 µM 1.51037278739834 0.0654344598407685 no 277 0.0654741641576352 423 244052
SGTC_2239 6685329 187.64 µM 1.5090909099461 0.0656020578624212 no 278 0.0656377761081688 431 805680
SGTC_2567 aureobasidin a 60 nM 1.50522213806553 0.0661098957737265 no 279 0.0661334876843623 469 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_442 cape 100 µM 1.50419765556062 0.0662448841210422 no 280 0.0662652406209318 380 5281787
SGTC_3065 9113888 49.47 µM 1.50177154150044 0.0665654062071956 no 281 0.0665780601775837 380 16648368
SGTC_593 1203-0218 61.7 µM 1.50063879338758 0.0667154678488128 no 282 0.0667245059160576 405 3666956
SGTC_1474 0330-0125 5.35 µM 1.49061261100043 0.0680551300083494 no 283 0.0680316157118453 413 X1474
SGTC_2157 5649910 96.377 µM 1.49009947256653 0.068124248338635 no 284 0.0680990414336974 446 2858091
SGTC_2309 7664088 163.95 µM 1.48687445675674 0.0685598902131185 no 285 0.0685239858618485 482 704922
SGTC_2625 euphol 100 µM 1.48298545235623 0.0690880794281815 no 286 0.0690391379670108 483 6708538 A triterpene alcohol.
SGTC_1314 1222-0010 41.1 µM 1.48139780077108 0.0693046072350642 no 287 0.069250300217257 406 3526027
SGTC_1620 st003704 16.5 µM 1.478110339998 0.0697546206747415 no 288 0.069689123458464 410 2834414
SGTC_134 0269-0018 6.916 µM 1.47688590024858 0.0699228052920369 no 289 0.0698531125423868 507 4378915
SGTC_1909 st060837 51.5 µM 1.47247378645611 0.0705314261035689 no 290 0.0704464903277865 459 678937
SGTC_2102 5377816 72.7585 µM 1.47128257796534 0.0706964412508044 no 291 0.0706073564457159 444 1379702
SGTC_942 3253-1115 227 µM 1.46947212406403 0.0709478068171164 no 292 0.0708523886665075 434 46497897
SGTC_1736 st036774 51 µM 1.46897152763984 0.0710174312292763 no 293 0.0709202560343784 459 1272247
SGTC_890 0929-0006 47.2 µM 1.46126228181332 0.0720962937274613 no 294 0.0719717383513334 409 1378169
SGTC_754 3474-0146 171 µM 1.45681826787549 0.0727238903650023 no 295 0.0725832759388305 417 24762078
SGTC_3215 9129942 49.47 µM 1.45445596867779 0.0730591996952394 no 296 0.0729099662550535 389 17682944
SGTC_1878 temozolomide 1 mM 1.45198934630807 0.0734105782104415 no 297 0.0732522837775455 410 5394 DNA alkylating agent.
SGTC_245 methotrexate 289.6 µM 1.45167881702315 0.0734549055809088 no 298 0.0732954659866083 502 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3219 9131112 49.47 µM 1.44824874724741 0.0739459032089698 no 299 0.0737737479332818 432 17612988 YMR079W SEC14
SGTC_447 ml7 120 µM 1.44604455992652 0.0742627428429358 no 300 0.0740823520030877 449 4216 Selective myosin light chain kinase inhibitor.
SGTC_2999 9069765 71.4286 µM 1.44265112487537 0.0747525555019331 no 301 0.0745593868868428 475 2097066
SGTC_1408 3909-7976 48.8 µM 1.4405927321637 0.0750508653382887 no 302 0.0748498874413076 499 24152374
SGTC_1987 st072290 61.9 µM 1.43648875354295 0.0756483373690582 no 303 0.0754316571386119 467 54697379
SGTC_2420 aureobasidin a 50 nM 1.43449409711486 0.0759400320824892 no 304 0.0757156561975403 508 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_237 nikkomycin 200 µM 1.4335688876406 0.0760756233513935 no 305 0.0758476636678769 478 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_275 trichlorophene 5.69 µM 1.43258313406993 0.0762202901827237 no 306 0.0759885022571976 645 62616
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.42902244892721 0.0767445921955777 no 307 0.0764988906380921 366 77254
SGTC_1659 st012954 42.1 µM 1.42647365327561 0.0771215769214083 no 308 0.0768658333480728 438 24207262
SGTC_2551 apiole 73.87 µM 1.42380349328709 0.0775180198357557 no 309 0.0772516821033405 304 10659 A possible DNA adduct former.
SGTC_385 1494-0393 12.4 µM 1.42049617601781 0.0780112056798471 no 310 0.0777316405370894 477 3090647
SGTC_1107 amlodipine 47 µM 1.41566716240957 0.0787355769622068 no 311 0.0784364885130989 480 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3306 9127676 59.7925 µM 1.41403303691319 0.0789818530159711 no 312 0.078676101304583 444 41905287
SGTC_133 0724-0033 378.92 µM 1.41208286775912 0.0792765225568935 no 313 0.0789627813099607 438 280309
SGTC_1427 4048-4900 550 nM 1.40598228417368 0.0802036920237627 no 314 0.0798646927289101 472 24132586
SGTC_1772 st048439 82.2 µM 1.40483433918595 0.0803790697590328 no 315 0.0800352726470006 498 2927068 YDL195W SEC31
SGTC_1166 k206-0078 225 µM 1.39718739458815 0.0815547361716821 no 316 0.0811786131658767 515 5404595
SGTC_1304 1165-0502 251 µM 1.39536466453647 0.0818368729899489 no 317 0.0814529506129858 550 767425
SGTC_2644 guaiazulene 100 µM 1.39506208366488 0.0818837800004595 no 318 0.081498559376327 442 3515 A coloring agent.
SGTC_2831 7999036 19.48 µM 1.39484805317967 0.0819169718928457 no 319 0.0815308323485385 517 2988270
SGTC_940 3232-1287 54.8 µM 1.39474148774911 0.0819335018624611 no 320 0.0815469046021847 486 1585493 YIL048W NEO1
SGTC_671 0560-0003 407 µM 1.39059427496836 0.0825787536640999 no 321 0.0821742466951759 463 3238678
SGTC_815 1582-0027 36.9 µM 1.38843257343571 0.0829165988540409 no 322 0.0825026816485133 493 3128206
SGTC_1496 4469-0713 57.4 µM 1.38235249070197 0.0838724092751082 no 323 0.0834317480673611 484 746691
SGTC_1118 chelidonine 707.474 nM 1.38072284958542 0.0841299953546115 no 324 0.0836820964544148 536 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1973 st070275 50.2 µM 1.37708496024475 0.0847071531681658 no 325 0.0842429910018284 440 17118334
SGTC_986 1493-0483 84 µM 1.37533868944321 0.084985254771015 no 326 0.0845132335573718 465 40079
SGTC_2375 9072683 200 µM 1.37320457977515 0.085326050065536 no 327 0.0848443781759084 555 16798029
SGTC_372 0155-0182 15.9 µM 1.37309970094671 0.0853428244864021 no 328 0.0848606770125871 527 771486
SGTC_1568 digitonin 820 nM 1.37274264665639 0.0853999506147695 no 329 0.0849161831190296 538 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_523 1934-0222 13.7 µM 1.3692941343046 0.0859531628325711 no 330 0.0854536754026405 511 1361595
SGTC_335 4077-0256 27.6 µM 1.36714260293814 0.0862996685565352 no 331 0.0857903059444739 581 3121989
SGTC_1880 MG-132 525 µM 1.36444530780224 0.0867355443965621 no 332 0.0862137281966342 458 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1813 st051246 8.6015 µM 1.35750098646432 0.0878652959004686 no 333 0.0873110401139374 455 5291959
SGTC_1455 4262-0120 131 µM 1.35421338013251 0.088403959379924 no 334 0.0878341557357445 522 1529587
SGTC_559 1550-0661 158 µM 1.35237123299558 0.0887068628095185 no 335 0.088128293617621 502 5830875
SGTC_1741 st038134 10.228 µM 1.34801763236118 0.0894257942282292 no 336 0.0888263557596543 549 1272587
SGTC_1277 0873-0036 22 µM 1.34780503276193 0.0894610125056596 no 337 0.0888605493964802 561 5965735
SGTC_974 1326-0144 138 µM 1.34031316799719 0.0907086767056203 no 338 0.0900717761041586 538 5411856
SGTC_2529 gangaleoidin 93.61 µM 1.34030949433791 0.0907092916533116 no 339 0.0900723730269374 494 4565183
SGTC_2297 7971671 152.32 µM 1.3386907041184 0.0909805682203848 no 340 0.0903356918799623 494 909016
SGTC_611 3453-1652 23.7 µM 1.33453356616339 0.0916799771044242 no 341 0.0910145269237742 551 1560575
SGTC_3240 9133527 49.47 µM 1.3339438729421 0.0917795105424364 no 342 0.091111125831647 523 17617455
SGTC_2607 solasodine 47.35 µM 1.33143465936002 0.0922039320245411 no 343 0.0915230156982108 533 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.33017862741198 0.0924169286735794 no 344 0.0917297121167091 491 2374 Ca(2+)-ATPase inhibitor.
SGTC_418 lividomycin a 100 µM 1.32649424506773 0.0930438226846886 no 345 0.0923380200556946 553 72394 An antibiotic.
SGTC_1375 2910-0797 186 µM 1.32369114478285 0.0935228687006766 no 346 0.0928028202936114 518 742508
SGTC_1088 bifonazole 369 nM 1.32266677193031 0.093698386323045 no 347 0.0929731091371429 515 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_748 act1.228 77.9 µM 1.31980939806323 0.0941892582944027 no 348 0.0934493315197729 591 4421505 YNR035C ARC35
SGTC_440 fluspirilene 35.1 µM 1.31973973440102 0.094201249549178 no 349 0.0934609644262847 548 3396 An atypical antipsychotic.
SGTC_934 2950-0684 338 µM 1.31869365850317 0.0943814467592196 no 350 0.0936357738470889 578 1121253
SGTC_1609 st001574 46.4 µM 1.31782414723713 0.0945314222679398 no 351 0.0937812612511983 538 3960012
SGTC_1679 SEC14.276 6.7 µM 1.31683611416858 0.0947020538847685 no 352 0.0939467822929882 606 1005053 YMR079W SEC14
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.31666399324126 0.0947318020757482 no 353 0.0939756390278927 520 689007
SGTC_1633 st005664 67.9 µM 1.31601509102655 0.0948440157716387 no 354 0.0940844887918542 555 2063822
SGTC_2136 5328288 199.296 µM 1.31422273215117 0.0951544745616982 no 355 0.0943856303742021 448 262395
SGTC_1259 0671-0132 43 µM 1.31096576943651 0.0957205353525936 no 356 0.0949346643411409 539 X1259
SGTC_565 1418-0001 44.5 µM 1.30992824720211 0.09590137620571 no 357 0.0951100551189995 577 2862145
SGTC_2976 9009005 19.48 µM 1.30959402123309 0.0959596855045084 no 358 0.0951666060504637 540 2993148
SGTC_306 1672-3436 11.6 µM 1.30954849870669 0.0959676294135967 no 359 0.0951743103635535 556 6797378
SGTC_64 000l-0018 272.079 µM 1.30649294267306 0.0965019455045441 no 360 0.0956924887214481 666 6811119
SGTC_1403 3909-7815 62.9 µM 1.30550364107659 0.096675409288153 no 361 0.0958607040644964 481 6615483
SGTC_259 usnic acid 108.925 µM 1.29656051051828 0.0982538971208472 no 362 0.0973912236042142 562 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2074 5212007 75.395 µM 1.293790536276 0.0987466136987832 no 363 0.0978688912387973 465 758611
SGTC_3073 9114972 49.47 µM 1.29326913535539 0.0988395611525223 no 364 0.0979589958213 484 41905075
SGTC_38 0929-0051 58.268 µM 1.29325217920331 0.0988425849127431 no 365 0.0979619270762016 596 1379719
SGTC_1674 st016616 23.6 µM 1.28768761746917 0.0998385627234387 no 366 0.098927362824969 544 625830
SGTC_1366 1683-0113 21.9 µM 1.28734209787648 0.0999006466926315 no 367 0.0989875382210333 529 708623
SGTC_1260 0700-1617 7.75 µM 1.28214631369182 0.100837642675118 no 368 0.0998956624665029 600 2853078
SGTC_722 3534-0461 190 µM 1.2795018412249 0.10131699435286 no 369 0.100360195825991 561 658262
SGTC_1486 3970-0793 4.53 µM 1.27190406094507 0.102703442461823 no 370 0.101703604408363 574 2844330
SGTC_2098 5376439 882.5 nM 1.27058935982713 0.102944742826499 no 371 0.101937387106595 599 2844116
SGTC_2592 piperlongumine 83.33 µM 1.26964476914391 0.103118367174391 no 372 0.102105597326319 522 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_180 1486-1293 102.781 µM 1.26963737848119 0.10311972648332 no 373 0.102106914231795 564 4140536
SGTC_1985 st071382 65.5 µM 1.26793651899961 0.103432898960335 no 374 0.102410310679737 567 6123237
SGTC_2218 6965428 192.983 µM 1.26727451111252 0.103554978291235 no 375 0.10252857558603 574 675684
SGTC_2651 TUB2.036 5 µM 1.26451082350652 0.104065752939899 no 376 0.10302336917916 753 15992207 YFL037W TUB2
SGTC_353 1988-1175 58.3 µM 1.26225621037143 0.104483793303078 no 377 0.103428304080244 533 2788357
SGTC_2499 avocadenofuran 51.48 µM 1.26194200430576 0.104542148456148 no 378 0.103484827972561 575 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2101 5377231 179.231 µM 1.26006996841034 0.10489031719446 no 379 0.103822061394036 568 2844213
SGTC_554 4483-2211 187 µM 1.25957168349021 0.104983131527816 no 380 0.103911957916487 551 747107
SGTC_7 0192-1582 4.227 µM 1.25648953151073 0.105558557972189 no 381 0.10446926952225 690 252616
SGTC_790 1575-0012 79.1 µM 1.25210222190228 0.106381581431591 no 382 0.105266309092173 592 378741 YLR208W SEC13
SGTC_988 1497-1057 103 µM 1.2488826703192 0.106988483995975 no 383 0.105853995449869 584 3533044
SGTC_2605 digitonin 300 nM 1.24462374466592 0.107795145686032 no 384 0.106635044005479 673 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_585 0kpi-0023 191 µM 1.2435878219956 0.107992015278575 no 385 0.106825650233911 545 64601
SGTC_2608 thymoquinone 42.66 µM 1.24323250089858 0.108059601070774 no 386 0.106891084687576 534 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_999 SEC7.066 22.7 µM 1.23738636135449 0.10917597322578 no 387 0.10797183985664 626 740511 YDR170C SEC7
SGTC_912 3474-0017 2.18 µM 1.23488925929621 0.109655334396596 no 388 0.108435860677022 614 3360550
SGTC_2749 bexarotene 57.39 µM 1.2321693680841 0.11017918100284 no 389 0.108942911634632 582 82146 An retinoic acid receptor inhibitor.
SGTC_1836 st055642 81 µM 1.23200549208152 0.110210800489761 no 390 0.108973516280087 599 8571
SGTC_2694 st077685 81.9 µM 1.2314980340006 0.110308754605925 no 391 0.10906832575758 588 2838096
SGTC_2158 5657123 3.6195 µM 1.23081404646712 0.110440882788497 no 392 0.109196210392866 590 2858827
SGTC_1527 coumarin 137 µM 1.23005566084626 0.110587515309395 no 393 0.109338131100613 547 323 A hepatotoxic, DNA x-linker.
SGTC_2076 5212012 200 µM 1.22934149092597 0.110725726331017 no 394 0.109471898584989 484 604802
SGTC_697 0508-1955 564 µM 1.22899831273748 0.110792184521718 no 395 0.109536219313925 653 6243113
SGTC_2320 7373003 200 µM 1.22851634848247 0.110885567583619 no 396 0.109626598060413 567 5415828
SGTC_584 0986-0246 15.4 µM 1.22435282161835 0.111694620552556 no 397 0.110409579297752 663 53315 YDR232W HEM1
SGTC_2570 licareol 100 µM 1.22353782778154 0.111853482415465 no 398 0.110563312854452 611 443158
SGTC_903 1134-0042 114 µM 1.22348422939808 0.1118639356871 no 399 0.110573428575535 590 701009
SGTC_1422 4031-0024 15.5 µM 1.221290845567 0.112292309913869 no 400 0.110987959126998 594 782427
SGTC_3064 1327-0027 10 µM 1.21623676718581 0.113283845560662 no 401 0.111947370719532 426 16000455 YPR107C YTH1
SGTC_941 3237-0776 460 µM 1.21622551880418 0.113286059270634 no 402 0.111949512583866 572 760008
SGTC_1207 2099-0101 141 µM 1.21462521669428 0.113601317332051 no 403 0.112254533336138 653 5837381
SGTC_1770 st043884 66.3 µM 1.21239356904525 0.114041993444027 no 404 0.112680880728627 617 670149
SGTC_2054 5233173 129 µM 1.21073169721639 0.114370947964214 no 405 0.112999125041559 662 6889
SGTC_2363 9053361 176 µM 1.20577599118129 0.115355900507378 no 406 0.113951937589417 640 6469797 YMR079W SEC14
SGTC_2785 7756463 72.73 µM 1.20489392448668 0.115531842448613 no 407 0.114122127165951 596 2201551
SGTC_1028 k015-0029 4.8 µM 1.20172653636591 0.116165198652153 no 408 0.11473474817537 642 4588309
SGTC_2791 5663188 71.43 µM 1.1994949053106 0.116612916501694 no 409 0.115167782293193 577 54690634
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.19945473077 0.1166209876597 no 410 0.11517558854576 653 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1650 st011916 45.8 µM 1.19410712909712 0.117698871143388 no 411 0.116218032445148 603 242528
SGTC_2899 9053889 58.44 µM 1.19200213811468 0.11812508944083 no 412 0.116630203451752 598 6470052
SGTC_427 1354-0053 47.3 µM 1.18648528050128 0.119247317875252 no 413 0.11771535550388 614 6813657
SGTC_1990 st072050 59.8 µM 1.18332975590871 0.119892581209168 no 414 0.11833924218781 644 17233948
SGTC_175 3793-3120 23.7 µM 1.17871293578608 0.120841089278444 no 415 0.119256251447229 598 5322297
SGTC_1977 st070720 65.3 µM 1.1768978311915 0.121215438067476 no 416 0.119618143920366 575 682188
SGTC_2885 9057732 51.95 µM 1.17657102906642 0.121282924579589 no 417 0.119683383372149 631 6471414
SGTC_3202 9113761 49.47 µM 1.17422953831496 0.121767228733669 no 418 0.12015154880352 701 4798415
SGTC_883 0850-0245 24.6 µM 1.17199699361632 0.122230262857128 no 419 0.120599131587109 670 6823229 YPR165W RHO1
SGTC_2228 7354201 200 µM 1.17173086669255 0.122285540444997 no 420 0.120652563184613 624 753451
SGTC_749 1000-0129 128 µM 1.16980675333548 0.122685722775345 no 421 0.121039372662888 686 708470
SGTC_3346 9158254 43.5805 µM 1.16944690763501 0.122760666312376 no 422 0.121111810106109 643 17639500
SGTC_3316 9136639 10.545 µM 1.16905832784429 0.122841630226153 no 423 0.121190066000738 617 4903665
SGTC_2520 obtusaquinone 4.71 µM 1.16563845124522 0.12355580585051 no 424 0.121880327326943 640 5967872
SGTC_209 4077-0173 175.592 µM 1.16462188927721 0.12376865486552 no 425 0.122086039694421 528 15993494
SGTC_3030 9087619 49.47 µM 1.15685841418893 0.12540264833783 no 426 0.123665105711303 616 25236973
SGTC_1874 staurosporine 7.6 µM 1.15591992236743 0.125601189947862 no 427 0.123856956449883 688 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_621 3584-0052 32.1 µM 1.15583722050995 0.125618696358593 no 428 0.123873872720094 688 2273927
SGTC_1503 4585-0012 61.3 µM 1.15543334886974 0.125704212763603 no 429 0.123956505968176 636 2922052
SGTC_3173 9105693 49.47 µM 1.15380496817716 0.126049420561366 no 430 0.124290068437746 682 17096658
SGTC_1771 st048882 4.1505 µM 1.15372491311848 0.126066408824797 no 431 0.124306483335615 655 4580403
SGTC_2641 levomentholum 100 µM 1.15343474735282 0.126127997480395 no 432 0.12436599311277 608 16666
SGTC_2398 5228213 48.84 µM 1.1527242191554 0.126278898024045 no 433 0.124511798673731 753 80771 YMR134W ERG29
SGTC_3081 9117243 49.47 µM 1.15114970325105 0.126613738730695 no 434 0.124835326543495 638 45595589
SGTC_3034 9090421 49.47 µM 1.15049557308402 0.126753029434646 no 435 0.124969908245454 614 17173761
SGTC_106 0092-0003 11.579 µM 1.14740941516833 0.127411636028838 no 436 0.125606225890275 583 1072148
SGTC_2469 5655019 90.81 µM 1.14684791553296 0.127531719219069 no 437 0.125722241008054 700 2788239
SGTC_1908 st060353 56.5 µM 1.14654599909346 0.12759632006353 no 438 0.125784652835557 720 4227716
SGTC_3225 9130819 49.47 µM 1.14636983698684 0.127634023851605 no 439 0.125821078850651 668 4547121
SGTC_1686 st019653 115.5 µM 1.14363382387726 0.128220604256867 no 440 0.12638776410249 659 97252
SGTC_1905 st060207 84.5 µM 1.14303457122672 0.128349328993026 no 441 0.126512118834583 668 1948547
SGTC_182 3448-4371 550.524 µM 1.13929758321077 0.129154091156523 no 442 0.127289528038256 716 3491403
SGTC_1367 1812-0510 76.9 µM 1.13860329933903 0.129303990015826 no 443 0.127434325844978 655 1142582 YDR527W RBA50
SGTC_2751 anetholtrithion 17.25 µM 1.13739621954555 0.129564890675963 no 444 0.127686343485293 661 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_645 0845-0943 5.41 µM 1.13728569885805 0.129588797051031 no 445 0.127709435617416 636 1885106
SGTC_1667 st014849 34.6 µM 1.13612196098076 0.129840706938251 no 446 0.127952762587893 708 5348460
SGTC_1634 st006576 41 µM 1.13246759518719 0.130633956731708 no 447 0.128718950261257 673 3915356
SGTC_982 1491-0518 27.5 µM 1.13091707743217 0.130971536547873 no 448 0.129044997381817 625 3091256
SGTC_3199 9111318 49.47 µM 1.13043508042207 0.131076599981822 no 449 0.129146469613612 682 8548020
SGTC_1143 3454-2408 5.08 µM 1.12993278331653 0.131186150273138 no 450 0.129252274361884 633 X1143
SGTC_923 1900-2434 73.3 µM 1.12776734494306 0.131659153217302 no 451 0.12970909388151 664 5910570
SGTC_3150 9097574 49.47 µM 1.12733617696709 0.13175347480661 no 452 0.129800186131727 659 17217476
SGTC_1574 spiramycin 23.7 µM 1.12647009496193 0.131943078324106 no 453 0.129983295888084 676 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_32 0928-0142 34.1 µM 1.12603041389949 0.132039405719218 no 454 0.130076323026093 656 2244242
SGTC_3165 9101544 49.47 µM 1.12468294456557 0.132334917651053 no 455 0.130361705759609 682 5002184
SGTC_2075 5212009 200 µM 1.12150068915489 0.133034622860873 no 456 0.13103739916817 603 780898
SGTC_669 0108-0021 26.2 µM 1.12142241968713 0.133051864555718 no 457 0.131054048682484 801 17201
SGTC_2237 6667747 47.222 µM 1.12077804702869 0.133193869509685 no 458 0.13119117545236 656 729940 YDL015C TSC13
SGTC_2746 daunorubicin 9.88 µM 1.1202625887303 0.133307539755108 no 459 0.131300939713215 546 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3315 9136395 68.55 µM 1.11874035003088 0.133643617427369 no 460 0.13162546293007 752 16876844
SGTC_2724 maprotiline 69.64 µM 1.11417238291149 0.134655621742483 no 461 0.132602620408981 706 4011 A tricyclic antidepressant.
SGTC_3328 9140624 29.0385 µM 1.11384836147653 0.134727605880052 no 462 0.132672122829812 713 4904392
SGTC_1244 0416-0015 52.5 µM 1.11366605274312 0.134768118933204 no 463 0.132711238982592 678 96201
SGTC_2921 7974240 10.71 µM 1.11120283409057 0.135316320380251 no 464 0.133240525814617 677 2979074 YDR527W RBA50
SGTC_1331 1472-0049 76.2 µM 1.10926833999209 0.13574792177147 no 465 0.133657219380293 673 24051409
SGTC_3048 9093155 49.47 µM 1.10919412420941 0.135764498676217 no 466 0.133673223422622 622 25236002
SGTC_2313 7726885 200 µM 1.108764873444 0.135860403716495 no 467 0.133765813778409 669 726423
SGTC_169 k015-0017 16.025 µM 1.10705811854487 0.136242193073221 no 468 0.13413440074289 631 1840002
SGTC_1746 st038117 42 µM 1.10667680081811 0.13632759146944 no 469 0.134216844525455 695 2898218
SGTC_2886 9058944 51.95 µM 1.10192075233736 0.137395814429812 no 470 0.135248062859742 535 4949929
SGTC_1510 1123-0200 71.5 µM 1.10078416948886 0.137651938245247 no 471 0.135495301591516 788 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_987 1497-1013 404 µM 1.10000307862225 0.137828142348777 no 472 0.135665390262958 677 1676435
SGTC_1935 st074532 41.6 µM 1.09947271870607 0.137947872441691 no 473 0.135780963637951 792 2829742
SGTC_800 3448-7362 155 µM 1.09931564153663 0.137983346623821 no 474 0.135815206046606 938 15991913
SGTC_2236 dapsone 200 µM 1.09930178534496 0.13798647619367 no 475 0.135818226943669 746 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1063 disulfiram 1.84 µM 1.09913671455618 0.138023762929842 no 476 0.135854218860908 688 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1235 benzylparaben 21.5 µM 1.09878016133374 0.138104325802486 no 477 0.135931983760242 674 7180
SGTC_617 3770-0098 35 µM 1.09736815637347 0.138423681926276 no 478 0.136240243884465 669 5962639
SGTC_1456 k015-0012 13 µM 1.09723356204769 0.13845414965985 no 479 0.136269652631236 792 2989616
SGTC_610 4215-0184 155 µM 1.09719316858088 0.138463294305212 no 480 0.136278479417056 749 5605015
SGTC_2640 pentamidine 10.38 µM 1.09429409534696 0.139120688232631 no 481 0.136913007073485 774 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_653 0203-0016 55.2 µM 1.09329436412649 0.139347879117778 no 482 0.137132288296588 722 295302
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.09130966186518 0.139799654221627 no 483 0.137568323875167 665 17037758
SGTC_330 1488-0319 80.1 µM 1.08990611494982 0.140119742094715 no 484 0.137877251344375 712 6846614
SGTC_612 0302-0167 22.4 µM 1.08826664650464 0.140494263392691 no 485 0.138238705156008 783 235821
SGTC_75 0159-0059 199.013 µM 1.08254747765667 0.141806071218543 no 486 0.13950466544112 686 5377270
SGTC_3216 9129716 49.47 µM 1.08166975458728 0.142008126702655 no 487 0.139699648577925 655 8056934
SGTC_576 1073-0113 22.7 µM 1.08155295785396 0.142035028479927 no 488 0.139725608528964 905 5439563
SGTC_1670 st016595 4.04 µM 1.08122495567594 0.142110595628128 no 489 0.139798529821736 729 597879
SGTC_1284 0929-0043 16 µM 1.07770229704036 0.142923882671231 no 490 0.140583316528411 737 1239883
SGTC_2710 st078562 53.7235 µM 1.07608814979613 0.143297594640015 no 491 0.140943917461033 720 17250908
SGTC_2094 5332512 191.667 µM 1.07423970534495 0.1437263616238 no 492 0.141357630454369 761 755774
SGTC_3133 9127736 49.47 µM 1.07188184706091 0.144274547980783 no 493 0.141886552345104 737 27243420
SGTC_1809 st050081 57.6 µM 1.07014703463942 0.144678779147664 no 494 0.142276565352593 734 5036894
SGTC_3111 9122088 49.47 µM 1.0699823573215 0.144717190455231 no 495 0.142313625053499 604 16876704
SGTC_3246 9135460 32.98 µM 1.06874737321955 0.145005471812236 no 496 0.142591759396298 654 41446951
SGTC_3143 9086658 49.47 µM 1.06700131272498 0.145413712538014 no 497 0.142985621580475 820 25236626
SGTC_1017 4239-0030 168 µM 1.06664322750064 0.145497530716474 no 498 0.143066486298002 750 1149593
SGTC_1811 st050069 61.5 µM 1.06508834512281 0.145861863920969 no 499 0.143417976460541 723 3877702
SGTC_583 1488-1091 88.9 µM 1.06282385553617 0.14639356499178 no 500 0.143930919532281 866 4303273
SGTC_2354 9060492 162 µM 1.06119405835897 0.146777044899439 no 501 0.144300859529762 808 6471895
SGTC_956 1185-0240 191 µM 1.06054285789664 0.146930456091073 no 502 0.144448851505002 714 1416193
SGTC_392 N-ethylmaleimide 8.33 µM 1.06051721739511 0.146936498734794 no 503 0.144454680663667 708 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_687 k029-0044 34.9 µM 1.05947694353406 0.147181798473163 no 504 0.144691312110118 797 5829338
SGTC_108 0509-0257 621.132 µM 1.05621753605251 0.147952153405267 no 505 0.145434420437843 778 536624
SGTC_636 0kpi-0074 126 µM 1.05315033607032 0.148679541165448 no 506 0.14613604803496 714 616434
SGTC_128 0906-2981 13.371 µM 1.05242296298136 0.148852388071667 no 507 0.146302768932178 672 6740226
SGTC_1866 st057638 64 µM 1.05050846890649 0.149307974174231 no 508 0.146742199657466 754 688802
SGTC_2988 9073640 71.4286 µM 1.04974691116361 0.14948945821378 no 509 0.146917244710003 709 9102229
SGTC_1111 tnp00062 510.699 nM 1.04294905329796 0.151115951840849 no 510 0.148485944539592 788 676306
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.03330843071491 0.15344273931749 no 511 0.150729791565531 740 279621
SGTC_1058 3448-5425 97.3 µM 1.03190815858212 0.153782661645986 no 512 0.151057571812271 736 7279705
SGTC_2891 9063876 19.48 µM 1.03102241306796 0.153997937513232 no 513 0.151265154723124 713 6472478
SGTC_821 1114-0266 29.2 µM 1.02948598476123 0.154371831169479 no 514 0.151625681177327 753 3123235
SGTC_839 0122-0028 230 µM 1.02871037748713 0.154560804915665 no 515 0.151807895982089 816 759448
SGTC_3006 9075424 71.4286 µM 1.02844572697212 0.154625320972983 no 516 0.151870104081476 723 7465181
SGTC_72 0744-0168 198.391 µM 1.02836527636513 0.154644936613414 no 517 0.151889017959646 745 677577
SGTC_1685 st024049 53.0905 µM 1.02680113895003 0.155026634743255 no 518 0.152257056487051 744 1941139
SGTC_713 1488-1073 324 µM 1.02679900547931 0.1550271558009 no 519 0.152257558892596 784 3312542
SGTC_2900 5328528 85.29 µM 1.02659458012817 0.155077087977356 no 520 0.152305703598999 813 795359
SGTC_189 3970-0742 2.116 µM 1.02607344199387 0.155204427276508 no 521 0.152428483810168 774 2891807
SGTC_122 0236-0016 402.397 µM 1.02607112570488 0.15520499341218 no 522 0.152429029674741 836 6808838
SGTC_945 3381-0768 11.3 µM 1.02443432026891 0.155605393984079 no 523 0.152815089218417 826 1126236 YIL048W NEO1
SGTC_968 1309-0633 340 µM 1.02285894163797 0.155991411034938 no 524 0.153187272409489 766 3761976
SGTC_641 4092-0595 30 µM 1.02070755997422 0.15651958550084 no 525 0.153696505840489 796 786260
SGTC_22 0964-0034 14.468 µM 1.01983667220079 0.156733727020617 no 526 0.153902963838707 806 138402
SGTC_2778 tioconazole 65.09 nM 1.01944867190018 0.156829193996652 no 527 0.153995004641939 766 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2571 chrysanthemic acid 100 µM 1.01770135210853 0.157259593857974 no 528 0.154409952259407 725 2743 An insecticide.
SGTC_3260 9137109 49.47 µM 1.01444235946806 0.158064422103177 no 529 0.155185860210708 668 17478346
SGTC_3179 9107801 49.47 µM 1.00915079986923 0.159376954385268 no 530 0.156451159084046 785 4818259
SGTC_3177 9107506 49.47 µM 1.00839861748695 0.159564105308255 no 531 0.156631568190384 763 8897194
SGTC_591 4299-0174 154 µM 1.00544525355366 0.16030032401035 no 532 0.157341249277296 795 5509088
SGTC_1035 k081-0041 55.2 µM 1.00467221033497 0.16049339532885 no 533 0.157527356857942 834 731709
SGTC_44 0929-0055 61.211 µM 1.00247079258732 0.161044042135784 no 534 0.158058133051593 738 1379590
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.00084126690215 0.161452433122531 no 535 0.158451777594591 866 91467 include heat shock
SGTC_1023 4482-3888 16 µM 1.00035124412053 0.161575374366844 no 536 0.158570278063387 800 3303168
SGTC_472 calcifediol 10 µM 0.999006986707172 0.161912946805777 no 537 0.15889565337805 750 5283731 A vitamin D metabolite.
SGTC_329 k048-0121 21.3 µM 0.998944599298549 0.161928624797673 no 538 0.158910764765863 775 6832902
SGTC_2736 butenafine 14.65 µM 0.995957848338698 0.162680353988676 no 539 0.159635313070802 827 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3164 9100705 49.47 µM 0.992424654216815 0.163572542621231 no 540 0.160495208622106 770 17174235
SGTC_3237 9133362 49.47 µM 0.992031696898832 0.163671966662894 no 541 0.16059103175158 816 43845137
SGTC_1565 sinapyl alcohol 95.1 µM 0.989670463875778 0.16427021968089 no 542 0.16116760809681 770 5280507 A phenol propionate derived from cinnamic acid.
SGTC_248 streptozotocin 5.23457 mM 0.988082199803468 0.164673426327772 no 543 0.161556196302225 858 5300 DNA alkylating agent.
SGTC_1191 1487-1166 10.6 µM 0.986719344182772 0.165019920118377 no 544 0.161890122105056 902 3955771
SGTC_1043 0916-0009 19.3 µM 0.98519573114218 0.1654078434732 no 545 0.162263968544993 932 3101130
SGTC_224 benfluorex 43.875 µM 0.984071992550546 0.165694333507057 no 546 0.162540058290551 775 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_755 1995-0008 37.3 µM 0.982148285018434 0.166185514832019 no 547 0.163013400350597 849 689533
SGTC_2366 9070441 60.58 µM 0.981809971188681 0.16627199384312 no 548 0.163096737458058 830 6837235
SGTC_2025 5147754 141 µM 0.977722129284062 0.167319215315861 no 549 0.164105886922257 823 315777 YLR208W SEC13
SGTC_141 0443-0274 32.331 µM 0.969940325850084 0.169324475016822 no 550 0.166038118942265 937 1627241
SGTC_68 0986-0284 82.829 µM 0.969719602998642 0.169381576211913 no 551 0.166093138253411 681 423278 YIL048W NEO1
SGTC_506 n9-isopropylolomoucine 153 µM 0.96846550276933 0.16970624760177 no 552 0.166405969820212 845 6610355
SGTC_2260 7964312 200 µM 0.968225880126156 0.16976832839748 no 553 0.166465786236515 787 231951
SGTC_1137 ixabepilone 100 µM 0.967751720941029 0.169891215211896 no 554 0.166584190343136 855 154225 A novel microtubule stabilizer.
SGTC_739 1486-1183 203 µM 0.963929879049689 0.17088379539518 no 555 0.167540541300943 864 4346692
SGTC_651 3253-0966 34.4 µM 0.962823794348166 0.171171750387984 no 556 0.167817978822749 862 781462
SGTC_700 3453-2283 142 µM 0.962778025338931 0.171183672445359 no 557 0.16782946536233 891 565664
SGTC_830 4076-0286 57.8 µM 0.960124274869003 0.171875837659494 no 558 0.168496336264818 961 6866659
SGTC_2781 5567276 71.43 µM 0.960083359418643 0.171886523413781 no 559 0.168506631380201 800 2853274
SGTC_1745 st081495 74 µM 0.958536047993875 0.172290941018346 no 560 0.168896261564621 888 13842402 YBL026W LSM2
SGTC_2523 spermine 47.74 µM 0.957242215482678 0.172629573023988 no 561 0.169222506912266 844 1103 A DNA binding polyamine.
SGTC_837 0091-0265 12.5 µM 0.954720248623665 0.173290860801277 no 562 0.169859593617732 868 759367
SGTC_2693 st077581 40.7 µM 0.950843891886789 0.174310424915663 no 563 0.170841813875732 929 25238761
SGTC_2279 7948423 32.93 µM 0.950770606617324 0.174329737135009 no 564 0.170860418383055 815 1247112
SGTC_2616 abietic acid 100 µM 0.950558621161913 0.174385607441596 no 565 0.170914241202384 903 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2928 9011484 9.79 µM 0.949112095170382 0.174767153462698 no 566 0.171281801708383 792 2994751
SGTC_1081 sertraline 6 µM 0.943898816507265 0.176146637196794 no 567 0.172610678436008 891 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1146 3579-1023 7 µM 0.942376152104911 0.176550845851965 no 568 0.173000046187869 936 X1146
SGTC_529 4076-0302 30.3 µM 0.942315355757462 0.17656699710627 no 569 0.173015604319231 841 5816522
SGTC_2022 5136654 200 µM 0.941634058232245 0.176748055594946 no 570 0.173190013193655 827 1713771
SGTC_2893 9048488 25.97 µM 0.939942436384339 0.177198120525286 no 571 0.173623544153067 836 6467338
SGTC_1199 1638-0010 4.46 µM 0.937300438301017 0.177902484697613 no 572 0.174302018785248 849 3111136
SGTC_2602 kawain 100 µM 0.9371671115362 0.177938076731974 no 573 0.174336302172001 933 5369129
SGTC_2248 tofa 1.1 µM 0.934872779351579 0.178551259914339 no 574 0.174926933412166 844 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2050 5263056 171 µM 0.932690321768637 0.179135777021939 no 575 0.175489941673466 928 763468 YGL055W OLE1
SGTC_2989 9073649 71.4286 µM 0.932462774411835 0.179196789151715 no 576 0.175548708077755 940 21367202
SGTC_727 3032-0951 202 µM 0.932430247480865 0.179205511644854 no 577 0.175557109505074 839 3652836
SGTC_2996 9066192 71.4286 µM 0.931701569373987 0.179400985559766 no 578 0.175745387603206 850 6472854
SGTC_3168 9103419 49.47 µM 0.928810530437673 0.180177850900871 no 579 0.176493643083427 815 16649256
SGTC_383 2324-0395 7.37 µM 0.927708589098373 0.180474513972087 no 580 0.176779375941554 896 3146421
SGTC_358 0075-0058 9.45 µM 0.926643825712283 0.180761458943246 no 581 0.177055746199545 943 1069125
SGTC_2810 7959871 45.46 µM 0.925948670111402 0.180948951892031 no 582 0.177236328169372 916 2974535
SGTC_3238 9133470 49.47 µM 0.92552678043255 0.181062800697933 no 583 0.177345979998153 885 3534688
SGTC_98 0074-0023 107.663 µM 0.92507434994499 0.181184940933892 no 584 0.177463617165016 910 3563821
SGTC_3186 9110464 49.47 µM 0.924885626471371 0.181235904849202 no 585 0.177512702009382 851 17018021
SGTC_127 0180-0333 59.125 µM 0.924553350552217 0.181325656265654 no 586 0.177599144047127 941 771601
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.922206841407321 0.181960266452794 no 587 0.178210347608468 919 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_626 0214-0009 33 µM 0.92167773692065 0.182103553704537 no 588 0.178348348287057 918 3437874
SGTC_1109 tnp00067 928.257 nM 0.919484937444169 0.182698139287274 no 589 0.17892099028917 875 676295
SGTC_1345 1488-0192 31.4 µM 0.91794510832876 0.183116393163064 no 590 0.17932380211923 920 658348
SGTC_3345 9148410 3.559 µM 0.916093023672259 0.183620253579566 no 591 0.179809053266033 889 4903596
SGTC_262 fenpropimorph 62.5 µM 0.915235619231468 0.183853803090257 no 592 0.180033974578929 835 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1209 2323-2347 50.3 µM 0.914881315858268 0.183950366246172 no 593 0.180126969883092 900 5412760
SGTC_16 erodoxin 22.806 µM 0.914574761324977 0.184033941235172 no 594 0.180207456702428 949 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3264 9137442 49.47 µM 0.911861728316261 0.184774616874273 no 595 0.180920755293454 862 17015726
SGTC_2840 9008771 71.43 µM 0.909102840530993 0.185529708530756 no 596 0.181647921679928 860 2992978
SGTC_2493 resveratrol 26.09 µM 0.908672089548614 0.18564777519231 no 597 0.181761620543919 838 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1123 mangostin 811.285 nM 0.908280827576717 0.185755058509871 no 598 0.181864934665184 848 5281650 An antioxidant.
SGTC_3063 1327-0034 4 µM 0.908128220144694 0.185796913612095 no 599 0.18190524115761 869 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2150 5556613 200 µM 0.908088877669789 0.18580770488229 no 600 0.181915633150759 932 743190
SGTC_1442 4112-3290 3 µM 0.906919617897178 0.186128599266593 no 601 0.182224653036959 928 704353
SGTC_2612 dictamnine 15.46 µM 0.903870569205638 0.186967001775395 no 602 0.183032018293163 865 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1944 st076371 56.9 µM 0.902606494632823 0.187315270748371 no 603 0.183367389199421 852 24208455
SGTC_2447 5741742 33.78 µM 0.902263274461198 0.187409901555958 no 604 0.183458514842415 922 1776504
SGTC_742 0kpi-0133 140 µM 0.902119456218608 0.187449563127124 no 605 0.183496707265022 935 2728852
SGTC_1630 st005209 31.3 µM 0.9015304926675 0.187612039058098 no 606 0.183653164329022 969 3367314
SGTC_1529 apigenin 74 µM 0.900759368524743 0.187824898680378 no 607 0.183858137632766 912 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1248 0469-0687 58.6 µM 0.900213080490428 0.187975785194854 no 608 0.184003433207813 912 4017482
SGTC_2046 4110841 106 µM 0.899291173222614 0.188230588596453 no 609 0.184248793854741 936 44119630 YMR134W ERG29
SGTC_2443 5493264 126.67 µM 0.89855493998605 0.188434227042982 no 610 0.184444884513631 921 5340055
SGTC_1424 4048-1941 275 µM 0.898400109627501 0.188477069634808 no 611 0.184486139029892 1005 X1424
SGTC_2156 5649887 115 µM 0.897070563849512 0.188845211033295 no 612 0.184840632429762 988 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_852 0418-0143 439 µM 0.896651879469116 0.18896123331969 no 613 0.184952352772314 983 5369229
SGTC_454 lyso-paf C-16 6.67 µM 0.896496625003967 0.189004267287037 no 614 0.184993791017582 950 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_527 4476-4215 268 µM 0.894999475038221 0.189419562215618 no 615 0.185393684301257 890 4418754
SGTC_851 0394-0702 453 µM 0.893255698313921 0.189903976404834 no 616 0.185860128288087 972 762646
SGTC_2741 miltefosine 3.04 µM 0.892788236845825 0.190033964668371 no 617 0.185985293463937 823 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2318 6029776 164 µM 0.891779709376446 0.190314594813323 no 618 0.186255509752942 915 818325
SGTC_1390 3413-2614 145 µM 0.891674305858263 0.190343938798386 no 619 0.186283764711138 952 3421432
SGTC_3235 9132602 49.47 µM 0.891299789411735 0.190448225395332 no 620 0.186384180816413 929 4912240
SGTC_1719 st032227 49.2 µM 0.891058501112551 0.190515432308573 no 621 0.186448893279547 922 3125804
SGTC_3307 9126885 69.2785 µM 0.886872115261603 0.191683798565805 no 622 0.187573877996189 913 24824909
SGTC_654 1124-0271 80.9 µM 0.884635781339124 0.19230972472007 no 623 0.188176550872458 929 5403748
SGTC_819 1013-0258 27.7 µM 0.88410648450216 0.192458052031007 no 624 0.188319366533755 921 5753198
SGTC_714 4296-0578 26.1 µM 0.883657344552063 0.192583971447642 no 625 0.188440606573206 940 1589775
SGTC_2777 climbazole 1.536 µM 0.882822031214973 0.192818291053112 no 626 0.188666217554804 948 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1485 3909-9022 254 µM 0.88129398611531 0.193247384183302 no 627 0.189079360135319 998 714516
SGTC_2460 5552655 174.22 µM 0.880912586924734 0.193354576404404 no 628 0.189182567120394 901 5401989
SGTC_2029 5175081 200 µM 0.880640340074449 0.193431113553592 no 629 0.189256258591596 980 1380876
SGTC_2464 5717415 7.67 µM 0.877877591998602 0.194208853977357 no 630 0.190005075400695 931 5285744
SGTC_2020 4017018 200 µM 0.876135023217689 0.194700382056551 no 631 0.19047831746441 931 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2774 tamoxifen 10.92 µM 0.873281650586574 0.195506868140033 no 632 0.191254789790568 952 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_211 3455-0679 143.504 µM 0.871015074073442 0.196148943926009 no 633 0.191872961249546 958 748649
SGTC_2539 epi(13)torulosol 80 µM 0.869998345631533 0.196437377745348 no 634 0.192150654150992 925 6708597
SGTC_2850 9015429 58.44 µM 0.869128069899886 0.196684468725042 no 635 0.192388542506073 912 6457570
SGTC_1339 1486-1321 22.7 µM 0.864961437320197 0.197870076129706 no 636 0.193529977411145 942 3469382
SGTC_3297 9117502 71.43 µM 0.86410074578919 0.198115521235698 no 637 0.193766274680153 969 7453720
SGTC_1849 st056239 19.2 µM 0.863818312174511 0.198196103429754 no 638 0.193843853307059 908 5393181
SGTC_1906 st060206 94.7 µM 0.861488388009769 0.198861617412706 no 639 0.194484556944823 1002 5133468
SGTC_2815 7968870 71.43 µM 0.859981545886255 0.199292744609955 no 640 0.194899607582653 959 2977326 YHR190W ERG9
SGTC_966 1300-0360 30.2 µM 0.859637982138813 0.199391121421162 no 641 0.194994315511902 919 70588
SGTC_1219 1469-0211 33.1 µM 0.858474159757383 0.199724590130619 no 642 0.195315346549524 956 6822282
SGTC_2388 9080168 200 µM 0.857905044472876 0.199887780168135 no 643 0.195472449258575 887 15943073
SGTC_1268 0828-0275 2.46 µM 0.857641584333124 0.199963352763166 no 644 0.195545202686255 1003 745337
SGTC_2524 avocatin b 10.57 µM 0.857590089875675 0.199978125770247 no 645 0.195559424588448 937 6710748
SGTC_1761 st044296 37 µM 0.85751083535083 0.200000864017054 no 646 0.195581314581097 989 1826700
SGTC_2113 5491891 107.031 µM 0.85733176757498 0.200052244564681 no 647 0.195630778336761 966 789979
SGTC_1730 st033808 45.1 µM 0.855643711239005 0.200536994398435 no 648 0.196097442032329 1022 1045166
SGTC_3117 9124945 49.47 µM 0.854948522969262 0.200736832668535 no 649 0.196289823158774 861 17592065
SGTC_3278 9139605 49.47 µM 0.85346716559244 0.201163061024652 no 650 0.196700144254871 934 7958859
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.852873424991065 0.201334049205422 no 651 0.19686475016809 897 521171
SGTC_1106 tegaserod maleate 11.7 µM 0.85262637363921 0.201405221862599 no 652 0.196933266112821 970 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.849976031479103 0.202169703189695 no 653 0.197669206077117 1016 5393153
SGTC_1169 aniline yellow 25.8 µM 0.849499526442601 0.202307333191702 no 654 0.197801696797813 946 6051 A DNA damaging agent.
SGTC_164 4100-3994 89.624 µM 0.848792904322947 0.202511531556252 no 655 0.197998269599006 1033 4615967
SGTC_998 3996-0085 177 µM 0.848071076185339 0.202720251300094 no 656 0.19819919427945 1032 715391
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.847914169084291 0.202765638672718 no 657 0.198242886481336 932 5282362
SGTC_2377 9073351 62.6 µM 0.847478068571919 0.202891818171563 no 658 0.198364353145896 936 7337946 YHR072W ERG7
SGTC_2541 muurolladie-3-one 83.07 µM 0.847274777346977 0.202950653628774 no 659 0.198420991003383 930 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1008 4106-0037 6 µM 0.847064003392153 0.203011665455516 no 660 0.198479723884972 980 2905394
SGTC_345 1362-0200 395 µM 0.845389103176919 0.203496880799173 no 661 0.198946813256629 939 1419823
SGTC_2258 7960471 200 µM 0.844938541628937 0.203627525584808 no 662 0.19907257701459 879 2974708
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.844068473632693 0.203879951924776 no 663 0.199315571739702 1024 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2247 cerulenin 830 nM 0.843925485900222 0.203921453724675 no 664 0.199355522785729 974 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.841315503868967 0.204679878164494 no 665 0.20008560368652 1051 1273210
SGTC_1626 st003712 1.76 µM 0.838910496382003 0.205380223174993 no 666 0.20075976860356 917 24207035
SGTC_369 0957-0393 4.5 µM 0.836768503983516 0.206005174122384 no 667 0.20136135225552 959 6997992
SGTC_3126 9127922 49.47 µM 0.836050824390621 0.206214817391585 no 668 0.201563155688016 975 45595682
SGTC_465 cgp-37157 41 µM 0.835754349963003 0.206301458214993 no 669 0.201646556318183 890 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_107 0358-0022 2.6945 µM 0.835089674914787 0.206495779301826 no 670 0.201833609835305 898 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_21 0849-0113 22.993 µM 0.834071064176495 0.206793785587638 no 671 0.202120469812872 986 1560156
SGTC_1947 st076332 61.6 µM 0.833415355440967 0.206985755345505 no 672 0.202305258747712 1001 24208416
SGTC_8 0354-0001 70 µM 0.832381141871851 0.207288752994985 no 673 0.202596921532153 1075 4993152
SGTC_1170 0310-0127 64.8 µM 0.83221541761962 0.207337330255876 no 674 0.202643681456991 999 774975
SGTC_557 1315-0110 16.2 µM 0.832112624626682 0.207367464424128 no 675 0.20267268825383 1045 6833801
SGTC_3324 9138759 60.749 µM 0.83100471449964 0.207692416932444 no 676 0.202985483024834 1004 45595710
SGTC_1759 st043059 70 µM 0.830193477748577 0.207930545145234 no 677 0.203214701127899 1010 669426
SGTC_2506 ethyl hematommate 54.16 µM 0.828003501489795 0.208574189229959 no 678 0.203834258454452 921 3940691 An allergen.
SGTC_3107 9121808 49.47 µM 0.827784574889624 0.208638597282079 no 679 0.203896255932746 985 662681
SGTC_2013 4024628 200 µM 0.823865645590383 0.209793525570263 no 680 0.205007951274987 959 5230760
SGTC_1553 gossypol 38.6 µM 0.823526407460204 0.209893677209833 no 681 0.205104353203128 937 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_183 3914-0051 30.55 µM 0.822409581326827 0.210223590887438 no 682 0.20542191404315 1007 1596232
SGTC_2252 omeprazole 400 µM 0.822111132595568 0.21031180504738 no 683 0.205506825037432 929 4594 A proton pump inhibitor.
SGTC_3090 9117696 49.47 µM 0.821295469911267 0.210553005874013 no 684 0.205738993721174 990 7923821
SGTC_1579 chlormadinone acetate 49.4 µM 0.820060909274432 0.210918388273617 no 685 0.206090692661596 1026 45114258 A steroidal progestin.
SGTC_99 0109-0120 622.8 µM 0.819788755376131 0.210998985329062 no 686 0.206168271199018 989 759414
SGTC_2854 9024559 71.43 µM 0.819003363343842 0.211231676574122 no 687 0.206392247333707 987 3163529
SGTC_2165 5727197 32.143 µM 0.81646450668504 0.211984901651 no 688 0.207117257812254 987 1361712
SGTC_1695 st026914 34.495 µM 0.816135857898947 0.212082519501628 no 689 0.207211218655341 986 3289191
SGTC_1134 3477-0009 42.5 µM 0.815267566194943 0.212340552768476 no 690 0.207459584921789 1035 3973534
SGTC_466 geldanamycin 89.2 µM 0.814057456723313 0.212700471050043 no 691 0.20780601813369 929 5288382 HSP90 inhibitor.
SGTC_3127 9126946 49.47 µM 0.813622318877552 0.212829979474808 no 692 0.20793067397248 895 27243249
SGTC_81 0411-0046 9.971 µM 0.812948231079246 0.213030696521524 no 693 0.208123869999621 934 12925265
SGTC_196 k015-0023 18.111 µM 0.81197221201925 0.213321512550166 no 694 0.208403788296131 1024 5211998
SGTC_2211 7117706 200 µM 0.811609967872645 0.213429506199201 no 695 0.208507734916397 988 822771
SGTC_1309 pyrazolanthrone 13.4 µM 0.810747254126466 0.213686830095518 no 696 0.208755415272109 1069 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_672 1441-0018 53.7 µM 0.810539689689425 0.213748767846357 no 697 0.208815031742118 989 251141
SGTC_101 0490-5701 117.494 µM 0.809339063636478 0.214107242798011 no 698 0.209160071261609 963 4661669
SGTC_2761 levamisole 97.89 µM 0.808628924820332 0.214319435889906 no 699 0.209364310976034 1015 26879 An alkaline phosphatase inhibitor.
SGTC_1912 st060209 90.8 µM 0.808565711165431 0.214338330378565 no 700 0.209382497247453 988 688787
SGTC_1218 1348-1416 30.7 µM 0.808535346413944 0.214347406712271 no 701 0.209391233374249 1047 6787668
SGTC_570 0987-0065 62.6 µM 0.807850759581991 0.214552096018346 no 702 0.209588250162729 927 3104428
SGTC_3091 9116372 49.47 µM 0.807719204604368 0.214591443554159 no 703 0.209626122767556 985 17169793
SGTC_2142 5622915 118.518 µM 0.807094543517982 0.214778334270146 no 704 0.209806007770083 1013 5322196
SGTC_412 gemfibrozil 100 µM 0.80679380627501 0.214868344772915 no 705 0.209892644074849 996 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2655 perillic acid 100 µM 0.80464280310846 0.215512777463333 no 706 0.210512917263161 1017 5702197 An apoptosis inducer.
SGTC_775 4577-0580 57.3 µM 0.803672925309343 0.215803715599627 no 707 0.210792947224138 1048 2006902
SGTC_2093 5331342 194.4 µM 0.803479051708179 0.215861899930053 no 708 0.210848949968047 1043 33839
SGTC_2466 5983409 37.09 µM 0.802745678904533 0.216082078157444 no 709 0.211060872521826 987 2879657
SGTC_2843 9000894 45.46 µM 0.802523912518383 0.216148683992998 no 710 0.211124980875091 925 2242070
SGTC_1934 st074720 32.6 µM 0.802483113306354 0.216160939018617 no 711 0.21113677637731 1098 17250992
SGTC_3084 9116877 49.47 µM 0.801785267535162 0.216370616088889 no 712 0.211338591077379 970 27241325
SGTC_1534 6-azauridine 81.6 µM 0.8013153161154 0.216511885569503 no 713 0.211474563128138 1104 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_191 3914-0123 66.505 µM 0.799636436995447 0.217016999749495 no 714 0.211960735030223 920 3144412
SGTC_3280 9140961 49.47 µM 0.798381066344832 0.217395140092405 no 715 0.212324693620259 990 4901226
SGTC_2243 6634756 200 µM 0.79796490060399 0.217520580651708 no 716 0.212445429458596 1008 885676
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.797189130515918 0.217754524543756 no 717 0.212670598881115 1011 140250 A respiratory chain inhibitor.
SGTC_1740 st038286 13.222 µM 0.794822099955684 0.218469230836875 no 718 0.213358496785345 1031 716786
SGTC_3355 9151058 44.0485 µM 0.794542375913515 0.218553780477543 no 719 0.213439874795375 1082 17015728
SGTC_3180 9109287 49.47 µM 0.793162965977613 0.218970997594489 no 720 0.213841440637353 1000 18891271
SGTC_348 k064-0012 10.7 µM 0.792376582102226 0.219209052590806 no 721 0.21407056491745 1001 5066323
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.791869543582972 0.219362622706429 no 722 0.214218373631479 1079 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.790668719374828 0.219726570772573 no 723 0.214568667163264 1096 6728940
SGTC_1708 st033234 31.827 µM 0.790116727502543 0.21989398574858 no 724 0.214729800863312 1105 674664
SGTC_1042 0350-0096 82 µM 0.789168740501481 0.220181673812677 no 725 0.215006694768545 1022 3122515
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.78879475620347 0.220295227140966 no 726 0.215115987421909 1098 551469
SGTC_2636 apigenin dimethyl ether 100 µM 0.788532337005847 0.220374925857362 no 727 0.215192695696638 1030 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2771 fluoxetine 41.05 µM 0.788492392320035 0.220387058813035 no 728 0.215204373398908 1021 3386 A selective serotonin reuptake inhibitor.
SGTC_3322 9139058 2.11 µM 0.787882908447566 0.220572233323697 no 729 0.215382599693918 1046 4908926 YPR165W RHO1
SGTC_711 k292-0785 179 µM 0.787332015497392 0.220739683307042 no 730 0.215543766390588 1102 4146315
SGTC_333 3486-0131 40.1 µM 0.787237013856726 0.22076856746101 no 731 0.215571566700672 1097 6744690
SGTC_409 arachidonic acid 100 µM 0.787015293037925 0.220835987540499 no 732 0.215636456905995 1087 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1578 josamycin 24.2 µM 0.784832903661275 0.221500229547111 no 733 0.216275772772893 992 5282165 A P450 substrate.
SGTC_848 0368-0089 85.6 µM 0.784685493516721 0.221545137112568 no 734 0.216318995081602 1067 762535
SGTC_2009 4012297 12.05 µM 0.783525389150921 0.221898737135616 no 735 0.216659325179982 1007 45595307
SGTC_501 nsc-95397 161 µM 0.783455666475743 0.221919998882181 no 736 0.216679788998027 1030 262093
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.782862707990089 0.222100867026683 no 737 0.216853869299257 1072 688798
SGTC_1737 st035557 69.7 µM 0.782775667560505 0.222127423758269 no 738 0.216879429366106 932 5716916
SGTC_846 0335-0850 148 µM 0.782599621643779 0.222181142315854 no 739 0.216931131876811 1057 6819598
SGTC_1980 st071811 45.7 µM 0.77989721093142 0.223006684368396 no 740 0.21772569013831 1067 4974850
SGTC_3175 9106517 49.47 µM 0.778700276893895 0.223372885546614 no 741 0.218078146484775 1041 41468073
SGTC_670 4204-0025 119 µM 0.777868906228483 0.223627444098765 no 742 0.218323150290879 1102 719039
SGTC_146 3448-8650 53.125 µM 0.777225188006846 0.223824658350055 no 743 0.218512962050276 1112 2891488 YIL048W NEO1
SGTC_1203 3992-3522 103 µM 0.775048002932846 0.224492408875414 no 744 0.219155647525045 1123 5322312
SGTC_428 3448-4153 16.5 µM 0.773472909342211 0.224976199672085 no 745 0.219621277731418 1040 3834874
SGTC_1332 1480-0653 17.5 µM 0.773091154407583 0.225093544795375 no 746 0.219734217853399 1079 5749438
SGTC_2807 7945238 51.95 µM 0.77233806421411 0.225325133859877 no 747 0.219957113235546 1065 17148797
SGTC_1785 bathophenanthroline 24 µM 0.771391570969943 0.225616389172755 no 748 0.220237434869414 1013 72812 An iron chelator.
SGTC_1240 0356-0016 42.1 µM 0.770203793174824 0.225982193904007 no 749 0.220589507098521 1041 4305613
SGTC_3148 9097893 49.47 µM 0.769763006630655 0.226118029975446 no 750 0.22072024374622 1053 17174100
SGTC_2940 9060638 45.86 µM 0.769752783199711 0.226121181051674 no 751 0.220723276527448 1049 4027022
SGTC_849 0386-0493 241 µM 0.769306176613606 0.226258858804565 no 752 0.220855785682755 1051 726119
SGTC_702 1488-0190 94 µM 0.768058173644568 0.226643838187504 no 753 0.221226312278307 1092 949357
SGTC_2821 7996764 71.43 µM 0.764292328248181 0.227807750541573 no 754 0.222346528074709 1158 2987135
SGTC_783 0848-0141 92.7 µM 0.764265691221709 0.227815995227819 no 755 0.222354463226514 1026 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_894 0960-0238 55.9 µM 0.763736115620727 0.227979944195218 no 756 0.222512256961381 1083 6741907 YDL195W SEC31
SGTC_3251 9135047 49.47 µM 0.763455576249399 0.228066822022775 no 757 0.222595873073801 1067 17682963
SGTC_468 gf-109203x 121 µM 0.762107557421637 0.228484537972842 no 758 0.222997906338957 1014 2396 A protein kinase C inhibitor.
SGTC_1919 st067113 52.3 µM 0.761385449667738 0.228708477042148 no 759 0.223213437815394 1050 1268243
SGTC_3061 glucosamine 200 µM 0.761305201252679 0.228733371177269 no 760 0.223237397320694 1065 91431 and experimental redox chemotherapeutic
SGTC_3299 9121982 43.1275 µM 0.760369501205241 0.229023750147551 no 761 0.223516874230561 1130 17594604 YPL160W CDC60
SGTC_1449 4112-4002 201 µM 0.758877907438866 0.229487068834142 no 762 0.223962797908039 1082 2059539
SGTC_2087 5276107 200 µM 0.758830271033802 0.229501874298814 no 763 0.223977047510139 1107 144405
SGTC_507 nimesulide 162 µM 0.758723394308932 0.229535093689371 no 764 0.224009019697886 1092 4495 A COX2 inhibitor.
SGTC_682 0kpi-0099 17 µM 0.758707438346917 0.229540053347671 no 765 0.224013793148672 1125 1714895 YML126C ERG13
SGTC_519 k048-0011 62.8 µM 0.758264027855946 0.229677904499177 no 766 0.224146468757404 1076 6836379
SGTC_2819 7996655 46.38 µM 0.756322399495407 0.230282079872766 no 767 0.224727960722987 988 6456960
SGTC_730 1436-0052 41.2 µM 0.756059334803773 0.230364005874071 no 768 0.224806810866187 1141 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3118 9124250 49.47 µM 0.755296365000562 0.230601709026044 no 769 0.225035589621852 993 1504786
SGTC_2581 avocatin a 64 µM 0.754658310270027 0.230800600091896 no 770 0.225227013482213 1089 6710728 A skin care supplement.
SGTC_1885 st057546 99.9 µM 0.754533051815753 0.230839656245768 no 771 0.225264603306476 1137 702008
SGTC_3261 9137475 49.47 µM 0.75373445249302 0.231088749894959 no 772 0.225504344970529 964 17027690
SGTC_3334 9142812 21.919 µM 0.752470126871155 0.231483416279331 no 773 0.225884194068166 1071 45283678
SGTC_2623 humulene 100 µM 0.749766025759261 0.232328776744283 no 774 0.226697816960677 1025 6187145 An anti-inflammatory.
SGTC_2303 7774051 200 µM 0.749548161231986 0.232396960586032 no 775 0.226763440996076 1099 2953184
SGTC_354 2783-3500 4.88 µM 0.748952848571047 0.232583329005018 no 776 0.226942812670917 1100 6740761
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.74716786728642 0.233142632533555 no 777 0.227481118830485 1149 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_227 fluconazole 33.516 µM 0.746497820403392 0.233352776675695 no 778 0.227683373874434 1125 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1040 k898-0338 155 µM 0.746298739382171 0.233415233911501 no 779 0.227743486395294 1163 20969351
SGTC_1264 0783-0040 158 µM 0.746250612677864 0.233430333984765 no 780 0.227758019595869 1054 2855798
SGTC_1605 st000082 49.1 µM 0.744289200604137 0.234046200938383 no 781 0.228350766627575 1119 1114022
SGTC_2083 5306046 65.942 µM 0.744263626048845 0.234054237073671 no 782 0.228358501087817 1135 539837
SGTC_2916 7875993 68.79 µM 0.743151358811779 0.234403885785368 no 783 0.228695024187506 1098 1299250
SGTC_1610 st001799 48.1 µM 0.742714698493218 0.234541231871109 no 784 0.228827214455705 1019 621897
SGTC_1246 0422-0085 105 µM 0.740317533859185 0.235296022698129 no 785 0.229553672113738 1137 264295
SGTC_1731 st035964 63 µM 0.736896665087255 0.23637546376842 no 786 0.23059259611895 1072 6739575
SGTC_916 4466-0038 42 nM 0.735811118173567 0.236718572577819 no 787 0.230922827024759 1188 5722064 YGL116W CDC20
SGTC_2767 sibutramine 71.45 µM 0.735599947326908 0.236785349159188 no 788 0.23098709732662 1150 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2126 5251174 33.877 µM 0.734533373331787 0.237122780116159 no 789 0.23131186395706 1184 790722
SGTC_3327 9140648 26.9345 µM 0.734341948775237 0.237183368865133 no 790 0.231370178755721 1122 8029710
SGTC_249 wiskostatin 11.211 µM 0.733916701472376 0.237317996454289 no 791 0.231499753698062 1151 2775510 A n-wasp and actin depolymerizer.
SGTC_2685 mycophenolic acid 18.85 µM 0.733714279288507 0.23738209534018 no 792 0.231561446941273 1111 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1795 st049545 62.3 µM 0.732889123699842 0.237643486937406 no 793 0.23181302862471 1121 5291882
SGTC_3104 9120930 49.47 µM 0.732438176297957 0.237786404115377 no 794 0.231950582293308 1107 17014836
SGTC_491 tetrandrine 80.3 µM 0.732378123342959 0.237805440044039 no 795 0.231968903832523 1110 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_676 falcarinol 140 µM 0.729990610093305 0.238562924381949 no 796 0.232697962123597 1177 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.729552861499412 0.238701951645212 no 797 0.232831772383938 1143 2333 A French combination drug.
SGTC_2925 9010536 32.5 µM 0.729144911130319 0.238831555004559 no 798 0.232956512448315 1135 2994177
SGTC_1976 st070609 63.5 µM 0.728841025304132 0.238928122698146 no 799 0.233049456540236 1114 682556
SGTC_831 k061-1017 217 µM 0.727514299062962 0.239349974756498 no 800 0.233455479533843 1203 1240153
SGTC_563 tetrahydrosecaminediol 614 µM 0.726550900699293 0.239656556180781 no 801 0.233750557685941 1189 334274 A psychoactive constituent of the cannabis plant.
SGTC_1514 1189-1591 158 µM 0.726449774117127 0.23968875003 no 802 0.233781543612435 1155 767698 YMR146C TIF34
SGTC_860 0443-0016 25.1 µM 0.726286265305921 0.239740808378946 no 803 0.233831648727316 1189 5337942
SGTC_1839 st053978 48 µM 0.72615163774331 0.239783676073615 no 804 0.233872908031946 1205 3788398
SGTC_2186 6124449 200 µM 0.725529313773953 0.239981888894951 no 805 0.234063684051843 1116 3834182 YLR033W RSC58
SGTC_1606 st000094 49.2 µM 0.725342122772891 0.24004152749684 no 806 0.234121085094451 1186 1242210
SGTC_1520 flindersine 88 µM 0.722824190657198 0.240844519445431 no 807 0.234893951638441 1205 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3178 9107506 49.47 µM 0.722339682016186 0.240999201243662 no 808 0.235042830713677 1144 8897194
SGTC_1815 st051655 58.2 µM 0.721287933724138 0.241335162975594 no 809 0.235366189647561 1135 5984156
SGTC_2324 6149169 200 µM 0.720441259701579 0.241605802259831 no 810 0.23562667700508 1099 2888231
SGTC_609 0986-0026 86.3 µM 0.720199428966022 0.241683133679349 no 811 0.235701107728663 1133 2848610
SGTC_2095 5432005 200 µM 0.719684997126817 0.241847680793676 no 812 0.235859482806995 1159 783734
SGTC_2678 equilin 100 µM 0.718845561413669 0.242116314716902 no 813 0.236118040816697 1184 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1096 rimcazole 32.2 µM 0.717976224317874 0.242394688044457 no 814 0.236385973377063 1094 18528119 A dopamine reuptake inhibitor.
SGTC_1560 lithocholic acid 53.1 µM 0.716567886302299 0.2428460244197 no 815 0.236820382774615 1113 9903 A bile acid which acts as a detergent.
SGTC_234 nsc-17383 10.7 µM 0.715089324055026 0.243320354786469 no 816 0.237276925170093 1190 408974
SGTC_280 3448-3607 3.04 µM 0.714881730741137 0.243386991850703 no 817 0.237341063378273 1158 626179
SGTC_2959 9079155 11 µM 0.714093032305446 0.243640252446164 no 818 0.237584827094972 1164 16189457
SGTC_229 benomyl 22.8748 µM 0.713939864645917 0.243689452928121 no 819 0.237632182684386 1169 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2327 6189656 200 µM 0.71354784094491 0.243815403126229 no 820 0.237753410144875 1180 5349088
SGTC_2264 7948757 110.76 µM 0.713501258295018 0.243830371632973 no 821 0.237767817386592 1167 2971411
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.712328374215781 0.244207420492105 no 822 0.238130728773252 1200 4213774
SGTC_560 2332-1943 155 µM 0.71174704865438 0.24439441656854 no 823 0.238310713780646 1173 21177716
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.711418485375 0.244500140250886 no 824 0.238412473658381 1189 688664
SGTC_3108 9121785 49.47 µM 0.710340184105836 0.244847284457492 no 825 0.238746603248282 1146 17140271
SGTC_627 1391-0720 175 µM 0.709879102512727 0.244995804238179 no 826 0.238889555208107 1121 997839
SGTC_640 3381-0960 37.1 µM 0.708670795836389 0.245385243793604 no 827 0.239264395923663 1207 1745025
SGTC_2764 methyldopa 94.69 µM 0.70834893197263 0.245489037218639 no 828 0.239364298654782 1182 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1157 4092-0394 27.6 µM 0.707459897903682 0.245775852032731 no 829 0.239640362642272 1242 3659885
SGTC_829 1635-0120 117 µM 0.706989925501261 0.245927544352558 no 830 0.239786369252914 1208 285054
SGTC_816 0325-0417 81.3 µM 0.70650563190568 0.246083911649739 no 831 0.239936875798544 1186 68101
SGTC_561 1550-0330 72.9 µM 0.704914644469882 0.2465979801723 no 832 0.240431678027635 1145 6812934
SGTC_2737 bleomycin 30.5 nM 0.703834543284451 0.246947302310922 no 833 0.240767909444647 1211 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_665 3914-0008 307 µM 0.703768907848891 0.246968538400484 no 834 0.240788349751111 1165 1069549
SGTC_1707 st032323 6.317 µM 0.703661482945579 0.247003297418004 no 835 0.240821806246777 1120 3132057 YMR211W DML1
SGTC_1278 0874-0585 172 µM 0.702773909999478 0.247290585736746 no 836 0.241098329411725 1199 766306
SGTC_1115 galangin 695.678 nM 0.700704386156995 0.24796113948546 no 837 0.241743759108966 1245 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2811 7967822 32.47 µM 0.699793029757783 0.248256738738242 no 838 0.242028284176632 1180 2232244
SGTC_1181 1222-0449 220 µM 0.699586843946602 0.248323641342242 no 839 0.242092680479353 1229 658318
SGTC_2708 st078559 56 µM 0.698647113276516 0.248628684254958 no 840 0.242386296389785 1116 17250902
SGTC_2479 5617353 43.85 µM 0.697821996398987 0.248896687233661 no 841 0.24264426057325 1214 2731746
SGTC_913 3487-1245 167 µM 0.696290214725743 0.249394626641375 no 842 0.243123549996377 1163 4016153
SGTC_2748 diazoxide 86.69 µM 0.696029157475818 0.249479541835114 no 843 0.243205284974799 1136 3019 A potassium channel activatior.
SGTC_1272 0839-0021 27 µM 0.696007581260807 0.249486560708981 no 844 0.243212040983133 1185 5027250
SGTC_1573 oleylamine 1.06 µM 0.695672572731459 0.249595554481509 no 845 0.243316952862141 1213 5356789 An amine of the fatty acid oleic acid.
SGTC_2299 7976368 114.88 µM 0.694392047493529 0.250012401603582 no 846 0.243718189787969 1189 2979718
SGTC_489 paxilline 115 µM 0.693739383405625 0.250225004225557 no 847 0.24392283144441 1192 105008 A toxic potassium channel blocker.
SGTC_2739 tacrine 100.86 µM 0.693252641830319 0.250383620665998 no 848 0.24407550872827 1207 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2291 7917025 104.35 µM 0.692498524979692 0.250629472978215 no 849 0.244312155945612 1175 2964612
SGTC_3114 9122766 49.47 µM 0.691974851755991 0.250800272744473 no 850 0.244476561047476 1148 17176985
SGTC_2408 sulbentine 18.36 µM 0.690693099873879 0.251218585161803 no 851 0.244879213253527 1168 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_323 4013-0906 34.3 µM 0.688154616403074 0.252048132101336 no 852 0.245677709942267 1228 2910086
SGTC_3226 9131256 49.47 µM 0.687211936215212 0.252356556634888 no 853 0.245974591832826 1122 17178073
SGTC_587 k089-0003 57 µM 0.686905447164722 0.252456876051232 no 854 0.246071157056422 1148 9659696
SGTC_1753 st043925 64 µM 0.686158326310296 0.252701510266302 no 855 0.246306636918198 1222 670181
SGTC_3287 9117173 37.0625 µM 0.686027149739075 0.252744475069338 no 856 0.246347994019013 1185 2789709
SGTC_2373 9071805 200 µM 0.685245669913492 0.25300051607292 no 857 0.246594454619414 1218 10149009
SGTC_762 1165-0429 115 µM 0.685006242734309 0.253078988364414 no 858 0.246669990818135 1206 5967793
SGTC_2061 5245884 80.95 µM 0.684680401408256 0.253185803471031 no 859 0.246772809473557 1212 573863
SGTC_2970 9090938 41.86 µM 0.68191919255735 0.254091915217465 no 860 0.247645024377868 1228 17217104
SGTC_1056 3448-1962 115 µM 0.681060572297443 0.254374024323873 no 861 0.247916581896619 1203 715507
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.680649127226951 0.254509267274769 no 862 0.248046766741593 1246 6708784 An antioxidant flavonoid
SGTC_1261 0712-0010 12.7 µM 0.680071631598448 0.254699154957818 no 863 0.248229552949862 1238 2840123
SGTC_2182 6325192 200 µM 0.678963785786828 0.255063635881358 no 864 0.24858040407181 1171 736248
SGTC_1433 4060-0023 7.6 µM 0.678949546499174 0.255068322377838 no 865 0.24858491532629 1228 3840627
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.67795054632774 0.255397230073895 no 866 0.248901524828998 1233 16486 A toxic proline analog.
SGTC_2634 4'-methoxyflavone 100 µM 0.676957220375047 0.255724489235947 no 867 0.249216548701964 1212 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2175 5807670 165.306 µM 0.67576579556402 0.25611730224726 no 868 0.249594677237929 1190 241186
SGTC_2476 5806916 10.51 µM 0.675653427402264 0.256154366286294 no 869 0.249630355812835 1154 2870194
SGTC_1057 3448-5381 134 µM 0.675350627628189 0.256254257099366 no 870 0.249726512762187 1246 5497911
SGTC_83 0170-0301 39.027 µM 0.674490759476595 0.256538030233596 no 871 0.249999679274407 1185 3089716
SGTC_2273 7815444 169.05 µM 0.674335253292494 0.256589367757218 no 872 0.250049098054443 1203 2824616
SGTC_2027 5150920 200 µM 0.671840907094324 0.257413561202888 no 873 0.250842491678784 1224 786715
SGTC_1472 k841-0093 193 µM 0.671829100578063 0.257417465635018 no 874 0.250846250223862 1292 X1472
SGTC_778 3456-2434 196 µM 0.671003326857912 0.257690626526974 no 875 0.251109205081797 1275 5539063
SGTC_2026 5148700 152 µM 0.670548254991586 0.257841225806535 no 876 0.25125417796835 1223 79838
SGTC_785 1270-0111 65.3 µM 0.668094131223247 0.258654168243562 no 877 0.252036753902258 1240 6741994
SGTC_395 anisomycin 6.25 µM 0.668051655705528 0.258668250173059 no 878 0.252050309893769 1192 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2835 9006588 71.43 µM 0.66592715866954 0.259373091776941 no 879 0.252728830122102 1243 2345538
SGTC_1928 4'-methoxychalcone 40.3 µM 0.662474616890855 0.260520649903675 no 880 0.253833548550752 1282 641818
SGTC_302 1094-0063 18.9 µM 0.661054118761877 0.260993553933649 no 881 0.25428880380701 1202 5440289
SGTC_2257 7960413 200 µM 0.658791730643285 0.26174764537603 no 882 0.255014759102986 1236 2974689 YIL048W NEO1
SGTC_2576 guaiol 23.12 µM 0.658238804139413 0.261932114774133 no 883 0.255192346944662 1258 227829
SGTC_1507 4075-3230 155 µM 0.657240238319641 0.262265428841709 no 884 0.255513228116583 1191 659771
SGTC_3213 9129884 49.47 µM 0.655014170893578 0.263009255356048 no 885 0.256229315151348 1194 17190742
SGTC_1763 st044482 94.5 µM 0.653326049333342 0.263574048648758 no 886 0.256773051142845 1264 88505
SGTC_2740 felodipine 17.08 µM 0.653129751038278 0.263639764133853 no 887 0.256836316856689 1219 3333 L-type calcium channel blocker
SGTC_2839 9003951 25.97 µM 0.65208428030915 0.263989900877415 no 888 0.257173402153188 1254 2990634
SGTC_1581 himbacine 57.9 µM 0.651428057420868 0.26420979631459 no 889 0.25738510188358 1262 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1400 3771-8998 51.5 µM 0.650742675346965 0.264439562333085 no 890 0.257606305105072 1220 670767
SGTC_1738 st035555 74 µM 0.650559094669769 0.264501122788956 no 891 0.257665571497519 1270 5331140
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.649413303710824 0.264885507760516 no 892 0.258035633615127 1298 23847180
SGTC_3124 9127567 49.47 µM 0.64927256941046 0.264932740262697 no 893 0.258081106311211 1243 17592030
SGTC_1487 3970-0795 2.82 µM 0.648447615644534 0.26520969293653 no 894 0.258347740885143 1308 3765103
SGTC_3136 9095672 49.47 µM 0.648206704611925 0.265290599078516 no 895 0.258425633030514 1125 17217380
SGTC_3350 9150499 3.57 µM 0.647660788907347 0.265473982546732 no 896 0.258602185298089 1243 4910996 YPR165W RHO1
SGTC_2111 5486399 200 µM 0.647499797406568 0.265528074931366 no 897 0.258654262794331 1272 689674
SGTC_2048 5246248 200 µM 0.64681230924678 0.265759130609404 no 898 0.258876712399858 1265 677046
SGTC_2233 sulbentine 40.3845 µM 0.645753827364896 0.266115071525572 no 899 0.259219397349553 1261 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2920 7982904 15.77 µM 0.643404155941806 0.26690606890338 no 900 0.259980943725674 1251 6456808
SGTC_1200 1643-0193 18.4 µM 0.642048961610905 0.267362823283065 no 901 0.260420696568341 1273 5403974
SGTC_828 2074-0507 139 µM 0.641776321184401 0.267454761570031 no 902 0.260509213101805 1337 X828
SGTC_1258 0671-0043 57.1 µM 0.641346146002098 0.267599855268497 no 903 0.260648906999031 1264 4298767
SGTC_1389 3405-0187 19 µM 0.640223952989303 0.267978546196572 no 904 0.261013506244583 1240 799890
SGTC_3105 9121040 49.47 µM 0.638146408054835 0.268680337977105 no 905 0.261689189675253 1155 41448907
SGTC_371 0195-0006 7.36 µM 0.636000906662011 0.269406053310883 no 906 0.262387915540521 1212 3928593
SGTC_1164 k060-0068 93.7 µM 0.634843094846617 0.269798090715944 no 907 0.262765376826828 1312 5963676
SGTC_462 ag-879 158 µM 0.633390224394123 0.270290439364006 no 908 0.26323942357713 1291 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_439 amiodarone 34.4 µM 0.633204161853323 0.270353524658566 no 909 0.263300164135756 1253 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2800 7887935 81.82 µM 0.632979447979179 0.270429724662788 no 910 0.263373532054906 1296 2961002
SGTC_3162 9099653 49.47 µM 0.630268707985854 0.271349775739158 no 911 0.26425939631335 1277 25237511
SGTC_1124 fisetin 1.16336 µM 0.629671117224885 0.271552813398351 no 912 0.264454891661772 1304 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1814 st052110 31.539 µM 0.628393461965085 0.271987163671895 no 913 0.264873109509592 1280 674163
SGTC_984 1492-0255 2.91 µM 0.627784452578723 0.27219432336446 no 914 0.26507257620232 1284 1585198
SGTC_1946 st076057 65.1 µM 0.627275385091123 0.272367547127358 no 915 0.265239367807017 1201 953009
SGTC_1720 st037298 9.481 µM 0.624393194499245 0.27334932069034 no 916 0.266184696682446 1300 597396
SGTC_2624 nerol 100 µM 0.623740478972075 0.273571901259754 no 917 0.266399017307588 1280 637566 A natural product oil.
SGTC_1652 st011932 78 µM 0.62274106527903 0.273912882046717 no 918 0.266727346162125 1292 1551076
SGTC_463 ikarugamyin 104 µM 0.622656678058619 0.273941682964123 no 919 0.266755078536963 1349 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1029 k015-0030 64.7 µM 0.621733428601093 0.274256880920994 no 920 0.267058583380406 1340 2208316
SGTC_307 1501-1223 22.3 µM 0.62063331912337 0.27463269268627 no 921 0.267420455910456 1287 2830329
SGTC_449 xestospongin c 11.1929 µM 0.620119317228855 0.274808369465866 no 922 0.26758961760386 1291 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1212 0520-0165 585 µM 0.619979147349108 0.274856286669288 no 923 0.267635757871569 1481 5403258
SGTC_1420 4'-methoxyflavone 42 µM 0.619584154836209 0.274991337374865 no 924 0.267765800671344 1322 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_304 1310-0298 97 µM 0.619455705668107 0.275035262087873 no 925 0.267808096659609 1258 1550234
SGTC_1305 1181-0477 144 µM 0.619340200617252 0.275074763357848 no 926 0.26784613325807 1358 6252086
SGTC_1376 2910-0861 41.3 µM 0.618556044102812 0.275343008846893 no 927 0.268104433257552 1360 1112859
SGTC_278 4092-0821 23.9 µM 0.618181924722291 0.27547103353465 no 928 0.268227711792683 1326 877900
SGTC_63 0099-0242 26.702 µM 0.616467023629796 0.276058251906939 no 929 0.268793164874028 1299 3898502 YLR359W ADE13
SGTC_490 phenamil 164 µM 0.615970420193992 0.276228414105247 no 930 0.268957021284025 1286 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_58 0957-0393 9 µM 0.615884465574453 0.276257871858752 no 931 0.268985387465326 1264 6997992
SGTC_2671 danthron 100 µM 0.615840386115028 0.276272979054284 no 932 0.268999934862719 1275 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_366 0181-0206 4.31 µM 0.615198821912561 0.276492905933179 no 933 0.269211712856222 1360 274874
SGTC_1011 4112-3381 17.4 µM 0.614444564762777 0.276751573454534 no 934 0.269460797295383 1367 2877139
SGTC_2226 7298446 200 µM 0.613965223973011 0.27691602181024 no 935 0.269619153893497 1312 3283010
SGTC_3314 9135860 59.4275 µM 0.609953262122591 0.278294286283978 no 936 0.270946384274793 1316 25252478
SGTC_2431 5490079 200 µM 0.609842694040291 0.278332318008948 no 937 0.270983008325776 1332 5722345
SGTC_1490 4089-0339 670 nM 0.609659719233079 0.278395260791916 no 938 0.271043621464293 1291 742542
SGTC_2525 harmine 47.85 µM 0.60837230643655 0.278838322919184 no 939 0.271470287278716 1325 5280953 A monoamine oxidase inhibitor
SGTC_725 1497-0963 19 µM 0.608191001805607 0.278900746322684 no 940 0.271530400922931 1353 3549977
SGTC_1558 st069300 45.6 µM 0.605202822399835 0.279930558435935 no 941 0.272522120364867 1311 24208000
SGTC_377 3970-0964 33.1 µM 0.60473737704653 0.280091130037415 no 942 0.272676754475 1354 16481235
SGTC_214 4373-3496 70 µM 0.603539541944772 0.280504570163359 no 943 0.273074909290892 1396 3779166
SGTC_1989 st071868 50.2 µM 0.603274211878507 0.280596190406335 no 944 0.273163142738827 1344 16414057
SGTC_2179 6298986 200 µM 0.601878099678422 0.281078515665022 no 945 0.273627641576513 1358 738374
SGTC_2952 9073731 13.78 µM 0.601625738567057 0.281165743458189 no 946 0.27371164603061 1316 16457353
SGTC_1356 1502-0781 85.8 µM 0.600000585274054 0.281727785343093 no 947 0.274252922722394 1309 567702
SGTC_2421 5690543 90.72 µM 0.599665627680266 0.281843694127661 no 948 0.274364550009044 1372 3397993
SGTC_3119 9125183 49.47 µM 0.598439248464625 0.28226826658706 no 949 0.274773441940474 1233 22695334
SGTC_156 3474-0145 5.642 µM 0.597989331768699 0.282424104868914 no 950 0.274923525730512 1289 2265471
SGTC_339 3091-4833 71.4 µM 0.595051291786338 0.283442774051644 no 951 0.275904592931023 1331 3240077
SGTC_2052 5265182 7.135 µM 0.594597816579448 0.283600158493282 no 952 0.276056169959359 1399 1239884
SGTC_1398 3558-0053 112 µM 0.593219194082268 0.284078884229705 no 953 0.276517234414139 1302 4532369
SGTC_194 1486-1323 56.904 µM 0.591860271266307 0.284551147230719 no 954 0.27697207971693 1319 5178754
SGTC_2132 5317594 122.667 µM 0.591806254877306 0.284569927155049 no 955 0.276990167118709 1377 794577
SGTC_157 1348-1695 65.819 µM 0.590835113807227 0.284907665543599 no 956 0.277315452569318 1341 5380510
SGTC_1755 st041960 45.185 µM 0.590289661247569 0.285097444014512 no 957 0.277498234777839 1367 2257073
SGTC_2488 5268135 45.7 µM 0.590040036332878 0.285184315722797 no 958 0.277581904204736 1400 1270356 YLR208W SEC13
SGTC_3356 9151811 4.48 µM 0.588455061469997 0.285736195314635 no 959 0.278113444435783 1341 1859254 YPR165W RHO1
SGTC_57 miconazole 162.5 nM 0.587148170071112 0.286191629561324 no 960 0.278552099190847 1285 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_597 k018-0003 82.8 µM 0.58663362183107 0.286371037317316 no 961 0.278724898405163 1460 6786234
SGTC_1975 st070967 30.8 µM 0.586181133944126 0.286528850564572 no 962 0.27887689918455 1363 261391
SGTC_1604 st002052 72.4 µM 0.584935611192841 0.28696346187006 no 963 0.279295506263885 1384 6254834 YHR062C RPP1
SGTC_2217 6934799 96.0675 µM 0.584125671053284 0.287246248931203 no 964 0.279567882343441 1341 675606
SGTC_14 0354-0009 295 µM 0.582322757584786 0.2878762013829 no 965 0.280174649648028 1392 1713507
SGTC_1333 1482-0047 286 µM 0.582042880312523 0.287974051221899 no 966 0.280268899027366 1331 3811116
SGTC_201 4262-0159 12.803 µM 0.579262075501966 0.288947119710033 no 967 0.281206175469949 1352 1341029
SGTC_891 0929-0073 133 µM 0.578957375811988 0.289053835218878 no 968 0.281308967117022 1427 5603632
SGTC_1621 st003705 32.4 µM 0.578852255133603 0.289090656119664 no 969 0.281344434201975 1404 24207032
SGTC_3351 9150312 21.596 µM 0.577196309356906 0.289670979527836 no 970 0.281903424963455 1366 4904905
SGTC_985 1493-0307 8.71 µM 0.576198499417855 0.290020924129895 no 971 0.282240509688148 1354 3278274
SGTC_1570 verbenone 133 µM 0.574162825553337 0.290735474717614 no 972 0.282928811302226 1417 29025 A natural terpanoid with antifungal properties.
SGTC_444 curcumin 90.4 µM 0.572115514039578 0.291454939545504 no 973 0.283621859710707 1371 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_380 3970-0968 6 µM 0.571490431764363 0.291674770915591 no 974 0.283833622222074 1337 2891601
SGTC_1349 flufenamic acid 69 µM 0.570904348275858 0.291880957217037 no 975 0.284032241631732 1353 3371 A non-steroidal anti-inflammatory.
SGTC_3129 9127257 49.47 µM 0.570674929874005 0.291961685929254 no 976 0.284110007955271 1275 837894
SGTC_1600 coumarin 106 71.1 µM 0.5705629524958 0.29200109277555 no 977 0.284147968804645 1421 100336 A hepatotoxic, DNA x-linker.
SGTC_3298 9116858 71.43 µM 0.569344271618481 0.292430128462725 no 978 0.284561264030316 1454 2506942
SGTC_1962 st076595 64.5 µM 0.568493401791761 0.292729850169633 no 979 0.284849992379202 1389 279619
SGTC_272 doxorubicin 8.13 µM 0.568260417715559 0.292811944453012 no 980 0.284929075971093 1369 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1064 honokiol 6.76 µM 0.568192845304661 0.292835756271291 no 981 0.284952014557563 1367 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1798 st045719 60.953 µM 0.567456151071549 0.293095417999025 no 982 0.285202154879153 1329 3980186
SGTC_1701 st028638 40.4 µM 0.567060878129722 0.293234783382216 no 983 0.285336410670291 1451 3490878
SGTC_2665 lovastatin 100 µM 0.566464518219097 0.293445106151939 no 984 0.285539023282248 1367 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_937 3122-0005 46.7 µM 0.566379352049219 0.293475148052136 no 985 0.285567963980547 1390 759535
SGTC_2424 5537928 59.2 µM 0.566289739694453 0.293506759857697 no 986 0.285598417064131 1383 5382802
SGTC_1186 1319-0216 26 µM 0.56540554888538 0.293818753010444 no 987 0.285898975606967 1473 4565136
SGTC_174 3553-0389 74.3 µM 0.564041932773288 0.294300215398172 no 988 0.286362797356691 1405 738071
SGTC_473 2-arachidonoylglycerol 10 µM 0.564035301934968 0.29430255748902 no 989 0.286365053649069 1345 5282280 An endocannabinoid.
SGTC_1437 4092-1038 11.6 µM 0.56351350591334 0.294486889026233 no 990 0.286542632975429 1365 3977136
SGTC_2449 5812982 45.77 µM 0.563429337868367 0.294516627522322 no 991 0.286571282211562 1376 776185
SGTC_1121 fusaric acid 630.51 nM 0.563397445381599 0.294527896229659 no 992 0.286582138175485 1377 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_786 4544-0069 423 µM 0.562852989901778 0.294720301672875 no 993 0.286767496831349 1446 748821 YLR208W SEC13
SGTC_759 3486-0358 89.3 µM 0.562579379727785 0.294817014812345 no 994 0.286860668257008 1448 875103
SGTC_309 k408-0051 1.48 µM 0.562282656532766 0.294921914257584 no 995 0.286961726482436 1366 3640463
SGTC_236 1509-0011 5.31 µM 0.562121582033544 0.294978865526761 no 996 0.28701659242712 1425 3107280
SGTC_1140 3229-1848 2.98 µM 0.56159701020921 0.295164374014683 no 997 0.287195308950415 1395 2849525
SGTC_2196 6573537 42.6665 µM 0.561220925782855 0.295297404779355 no 998 0.28732346967082 1468 2903087
SGTC_2937 9044753 11.33 µM 0.560521889816848 0.295544745115626 no 999 0.287561756539689 1352 6465530 YGL099W LSG1
SGTC_3190 9110366 49.47 µM 0.560078550468455 0.295701661505182 no 1000 0.287712930131792 1377 17123768
SGTC_1079 idarubicin 2.36 µM 0.559273446251043 0.295986719506293 no 1001 0.287987557339136 1376 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1476 4112-3294 3.34 µM 0.558667655146635 0.296201291150893 no 1002 0.288194278871321 1462 704369
SGTC_1271 0832-2808 169 µM 0.557751481135662 0.296525936133243 no 1003 0.288507049090429 1424 3663794
SGTC_2898 9056270 58.44 µM 0.556137997378991 0.297098067879888 no 1004 0.289058260608027 1359 19154699
SGTC_2212 7123476 200 µM 0.555727537808182 0.297243694901128 no 1005 0.289198564156281 1403 1085715
SGTC_1861 st057647 17.4 µM 0.554707177927454 0.297605849826543 no 1006 0.2895474828577 1502 688668
SGTC_199 4063-0024 41.6 µM 0.554257338567487 0.297765574629307 no 1007 0.289701371111567 1447 306215
SGTC_2114 5491910 81.25 µM 0.553979783233791 0.2978641459152 no 1008 0.28979634083013 1480 2849228
SGTC_967 1306-0166 352 µM 0.55365912213705 0.297978044347501 no 1009 0.289906078013264 1437 4437607
SGTC_2355 9061122 103.12 µM 0.552669871446896 0.298329550017903 no 1010 0.290244743798277 1432 5302957
SGTC_2202 7226349 200 µM 0.551048600320333 0.298906036255005 no 1011 0.290800179497326 1378 844334
SGTC_881 0833-0569 170 µM 0.550685655418834 0.299035160298395 no 1012 0.29092458982577 1354 5418700
SGTC_1351 1496-0003 46.5 µM 0.549971663648998 0.299289249341927 no 1013 0.291169404641521 1417 3891978
SGTC_3311 9131146 2.8755 µM 0.549579333499472 0.299428909989451 no 1014 0.291303968465795 1405 4900406 YPR165W RHO1
SGTC_2664 lyso-paf C-16 73.48 µM 0.54927582999919 0.299536970628899 no 1015 0.291408085882993 1421 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2270 7924575 90.91 µM 0.548495960528985 0.299814719601293 no 1016 0.291675701087819 1516 1262135
SGTC_3323 9138564 53.9225 µM 0.546508305802827 0.300523145687336 no 1017 0.292358289971959 1504 43912313 YNL103W MET4
SGTC_2812 7970281 58.44 µM 0.546470099545542 0.300536770298331 no 1018 0.292371417816972 1524 2233435
SGTC_2486 5283202 22.39 µM 0.546155369335937 0.300649015841364 no 1019 0.292479570986245 1356 1377751
SGTC_1319 1306-0155 43.7 µM 0.544979883303639 0.301068409001882 no 1020 0.292883676652732 1444 3122360
SGTC_2670 beta-carotene 100 µM 0.542924092844334 0.301802512667032 no 1021 0.293591033423473 1365 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2263 7948595 193.29 µM 0.541390898959855 0.302350525150061 no 1022 0.294119089438543 1416 2971371
SGTC_1125 tnp00248 1.32998 µM 0.541069879556913 0.302465324231804 no 1023 0.294229709102111 1526 24207736
SGTC_1862 st057513 3.81 µM 0.540846239913718 0.302545311088264 no 1024 0.294306784156146 1402 5393163
SGTC_2953 9074162 66.49 µM 0.540579263884472 0.302640810030805 no 1025 0.294398806848341 1502 16451992
SGTC_1952 st077036 64.1 µM 0.540210702170015 0.302772668977518 no 1026 0.294525866448166 1406 2937007
SGTC_1226 3909-7979 35.4 µM 0.53879331336661 0.303280002433233 no 1027 0.295014738980887 1481 6615510
SGTC_1447 4239-0816 81.9 µM 0.538600853949268 0.303348919741519 no 1028 0.295081149104189 1370 1341554
SGTC_535 2293-4129 48.2 µM 0.538495967461972 0.303386481225923 no 1029 0.295117344175689 1507 396118 YIL048W NEO1
SGTC_2329 6138490 200 µM 0.535589374691357 0.304428202947615 no 1030 0.296121186866974 1454 720019
SGTC_2868 9035608 32.47 µM 0.535275227927022 0.304540888301257 no 1031 0.296229776709088 1395 6462614
SGTC_2960 9079389 5.97 µM 0.533083517998403 0.305327576785759 no 1032 0.296987883931483 1513 16457355
SGTC_1721 st082152 9.2685 µM 0.532168606952721 0.305656239817738 no 1033 0.297304611824407 1379 5296051
SGTC_3004 9076122 71.4286 µM 0.532067969426201 0.305692401352238 no 1034 0.29733946038193 1490 44782551
SGTC_747 3448-8087 38.7 µM 0.530647819164055 0.306202898134474 no 1035 0.297831425966499 1432 5168703
SGTC_550 4123-0385 25.7 µM 0.530262023273341 0.306341644001536 no 1036 0.297965136691753 1403 5731123
SGTC_2794 7785382 27.27 µM 0.530058698753393 0.306414777877451 no 1037 0.298035616748333 1450 2205081
SGTC_2071 5230951 39.92 µM 0.529576793540445 0.30658814534723 no 1038 0.298202693864426 1456 1799272
SGTC_3144 9087057 49.47 µM 0.528252794496895 0.307064682447966 no 1039 0.298661945368256 1443 17249618
SGTC_2151 5563267 85.4165 µM 0.527056940647136 0.307495377521605 no 1040 0.29907702372839 1445 5310824
SGTC_2546 rhodinyl acetate 100 µM 0.526227891450238 0.307794121249977 no 1041 0.299364938592918 1462 6708682
SGTC_1128 3448-9350 235 µM 0.525707155153109 0.307981831158112 no 1042 0.299545845813597 1433 619386
SGTC_1556 plumbagin 1.48 µM 0.522847810614728 0.309013434062935 no 1043 0.30054008268095 1410 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_735 3076-0345 636 µM 0.522752133790251 0.309047978754064 no 1044 0.300573376696303 1541 2888990
SGTC_683 panaxydol 45 µM 0.521928448093718 0.309345445236238 no 1045 0.300860075092071 1446 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2139 5578692 56.4705 µM 0.519726250358985 0.310141362029464 no 1046 0.301627194036426 1476 650991 YMR113W FOL3
SGTC_753 1322-0200 289 µM 0.519276747257988 0.310303930659386 no 1047 0.301783883092929 1443 5403907
SGTC_251 melphalan 456.522 µM 0.519255164386476 0.310311737317943 no 1048 0.301791407431542 1546 460612 A DNA alkylator.
SGTC_804 1595-0054 20.9 µM 0.519045177933199 0.310387695181628 no 1049 0.301864618457377 1429 761523 Stimulates phospholipase C.
SGTC_2002 4023503 131 µM 0.517240927051455 0.311040675255886 no 1050 0.302493992672756 1542 4736863 YCR052W RSC6
SGTC_1031 k035-0009 16 µM 0.517208015038042 0.311052592043603 no 1051 0.302505478784493 1567 5180959
SGTC_84 0443-0269 128.823 µM 0.516853249695884 0.311181058116936 no 1052 0.302629302349367 1425 6150058
SGTC_2340 7987427 183.45 µM 0.516811489770587 0.311196181551973 no 1053 0.302643879288554 1498 2239331
SGTC_2446 5162541 200 µM 0.515040254483212 0.311837930923484 no 1054 0.303262445416476 1407 1549321
SGTC_2515 chrysin 20.77 µM 0.514383837674591 0.312075907466381 no 1055 0.303491828434596 1525 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2177 5811945 192 µM 0.513236660138275 0.31249199211042 no 1056 0.303892892359704 1532 5343475
SGTC_2787 5284540 71.43 µM 0.512512683250289 0.312754703770619 no 1057 0.304146123002608 1488 736958
SGTC_29 0299-0004 12.984 µM 0.512396063064222 0.312797030987273 no 1058 0.304186922881186 1391 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2883 9059145 45.46 µM 0.511700791405564 0.313049430570069 no 1059 0.304430216081335 1436 16476510
SGTC_3101 9120531 49.47 µM 0.511627305339603 0.313076112822682 no 1060 0.304455935781121 1519 24824904
SGTC_1346 1488-2224 62.4 µM 0.50993422269063 0.313691129594201 no 1061 0.305048772541251 1500 3722427
SGTC_1196 1588-0294 184 µM 0.508692942734375 0.314142357151738 no 1062 0.305483734947741 1433 6144269
SGTC_374 0880-0231 82.3 µM 0.508580722321941 0.314183164997395 no 1063 0.305523072148614 1446 6833587
SGTC_2404 5161160 200 µM 0.507503393772577 0.314575040418794 no 1064 0.305900827873001 1509 2831543
SGTC_801 0866-0028 10.1 µM 0.507120286586698 0.314714445042172 no 1065 0.306035210830991 1478 6849771
SGTC_1898 st060199 18.6 µM 0.506938829364794 0.314780482716258 no 1066 0.306098869907389 1452 688866
SGTC_2172 5754775 163.918 µM 0.5067586042524 0.314846077852565 no 1067 0.30616210253002 1403 2263357
SGTC_1661 st013063 9.66 µM 0.50611071886008 0.315081931908539 no 1068 0.306389463115071 1489 721395
SGTC_975 1335-0046 28.5 µM 0.506028325297043 0.3151119315956 no 1069 0.306418382600418 1401 16486740
SGTC_1555 citronellol 128 µM 0.504149256501563 0.315796435616712 no 1070 0.307078247835842 1532 8842 A terpine precursor.
SGTC_1402 3909-7673 35.9 µM 0.503376352579803 0.316078171405383 no 1071 0.307349847107711 1438 5328014
SGTC_310 1273-0058 1.06 µM 0.502851320873098 0.31626961477389 no 1072 0.307534404105404 1457 2734232
SGTC_263 alizarin 107.927 µM 0.502148200024951 0.316526072294954 no 1073 0.307781638592631 1510 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3189 9110682 49.47 µM 0.50197242488255 0.316590198617686 no 1074 0.307843459076602 1494 17122418
SGTC_1924 st058459 75.1 µM 0.500793472267335 0.317020446768158 no 1075 0.308258240089814 1466 688683
SGTC_2133 5320837 200 µM 0.500204501780965 0.317235478998528 no 1076 0.308465544420953 1534 2841355
SGTC_90 0870-0863 4.608 µM 0.500143663012687 0.317257694658352 no 1077 0.308486961777186 1457 1738164
SGTC_401 neomycin 50 µM 0.499336198938837 0.3175526075948 no 1078 0.308771278833415 1470 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1646 st011709 75.6 µM 0.49858146376303 0.317828366908418 no 1079 0.309037133134511 1533 5757843
SGTC_734 2023-0417 80 µM 0.498113006120528 0.317999579190908 no 1080 0.309202196950607 1512 3935732
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.497758054630507 0.31812933306269 no 1081 0.309327291856824 1504 756377
SGTC_1179 1021-1431 9.29 µM 0.497616713419738 0.318181007097068 no 1082 0.30937711063584 1500 2840958
SGTC_2335 9018011 154.17 µM 0.496552945792194 0.318570031680414 no 1083 0.309752171012812 1591 6458208
SGTC_2563 tomatine 8.54 µM 0.496111583765287 0.318731498504792 no 1084 0.309907843453965 1635 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1782 st039423 80.636 µM 0.495529927309684 0.318944342873788 no 1085 0.310113051092274 1439 2068169
SGTC_1877 wortmannin 25 µM 0.494684849691762 0.319253686817312 no 1086 0.310411298765619 1524 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1046 2001-0062 216 µM 0.493686568060955 0.31961927385712 no 1087 0.310763776378149 1479 739778
SGTC_1100 amiodarone 5.07 µM 0.493442171458945 0.319708802618269 no 1088 0.3108500954782 1526 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_37 0566-0070 1.56 µM 0.492994781657869 0.319872720226188 no 1089 0.311008137266424 1581 1626686
SGTC_3230 9131665 49.47 µM 0.491018464077836 0.320597237005246 no 1090 0.311706694189726 1478 15943720
SGTC_2105 5350118 200 µM 0.490872899959869 0.320650627799781 no 1091 0.311758172692447 1478 2133313
SGTC_2555 cholic acid 100 µM 0.489692723297871 0.321083636299263 no 1092 0.312175675899086 1505 6708657 Influences liver metabolism.
SGTC_313 3474-0040 5.03 µM 0.489655076321238 0.321097453037639 no 1093 0.312188997992977 1462 1043375 YIL048W NEO1
SGTC_2338 7999974 200 µM 0.489112984412907 0.321296432511021 no 1094 0.312380854676348 1573 315925
SGTC_882 0843-0131 351 µM 0.489031449001545 0.321326365221449 no 1095 0.312409716018883 1494 5425421
SGTC_896 0964-0007 44.5 µM 0.487707481257645 0.321812573313333 no 1096 0.312878525947828 1494 6756758
SGTC_2344 7990960 76.95 µM 0.485277464084401 0.322705756024886 no 1097 0.313739769572159 1511 140813
SGTC_2557 derrustone 83.84 µM 0.485093209550872 0.32277352287043 no 1098 0.313805114328436 1453 629853 An antioxidant.
SGTC_2982 9019404 25.97 µM 0.484582279056362 0.32296146842284 no 1099 0.313986343287977 1334 22333232
SGTC_784 4579-0127 173 µM 0.484549263030953 0.322973614908766 no 1100 0.313998055739816 1634 1948547
SGTC_1082 camptothecin 424.86 nM 0.484442903142895 0.323012745641558 no 1101 0.314035788238344 1366 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3284 9108171 64.8615 µM 0.483214076862263 0.323464983546487 no 1102 0.314471870615588 1513 8687505
SGTC_1998 st075797 76.8 µM 0.482168840520428 0.32384986128629 no 1103 0.314843004997714 1517 24208315
SGTC_1665 st014639 11.4 µM 0.481600511823816 0.324059210829318 no 1104 0.315044881266398 1577 981133 YIL048W NEO1
SGTC_666 0272-0154 136 µM 0.480944364810233 0.324300978340276 no 1105 0.315278020243262 1515 6870312
SGTC_2910 7948405 25.97 µM 0.480546940955525 0.324447451340644 no 1106 0.315419266748157 1585 2971328
SGTC_3 0833-0587 95.581 µM 0.479534562380561 0.324820692363989 no 1107 0.315779193210073 1479 5382644
SGTC_2881 9058953 51.95 µM 0.477997251835577 0.325387800245271 no 1108 0.316326080518285 1438 17122249
SGTC_426 0988-0037 14.6 µM 0.477893254792909 0.325426178973543 no 1109 0.316363091256654 1525 5383008
SGTC_2796 7949634 45.45 µM 0.477099298000856 0.325719239180223 no 1110 0.316645707272327 1479 2971588
SGTC_806 3966-4455 5.86 µM 0.476325879210473 0.326004822133042 no 1111 0.3169211155592 1454 714982
SGTC_375 3970-0961 9.27 µM 0.473811212071428 0.326934061583685 no 1112 0.317817269246926 1541 2898222
SGTC_170 4197-0004 226 µM 0.47302106220598 0.32722626600566 no 1113 0.318099076308433 1562 218692
SGTC_661 1304-0007 33.6 µM 0.472583291653836 0.327388203044999 no 1114 0.318255252598057 1502 3117130
SGTC_1473 k844-0725 134 µM 0.47225929833039 0.327508073324116 no 1115 0.318370859242486 1551 54682906
SGTC_129 0088-0017 176.636 µM 0.472218712661936 0.327523090366856 no 1116 0.318385342185862 1580 182446
SGTC_2295 7971645 200 µM 0.472017155869749 0.32759767222903 no 1117 0.318457271578663 1583 2978226 YKL099C UTP11
SGTC_2674 ligustilide 100 µM 0.471980285808752 0.327611315965975 no 1118 0.318470430104973 1518 5319022 A signalling regulator.
SGTC_858 0438-0351 2.77 µM 0.471784081749234 0.327683924994709 no 1119 0.318540457064605 1492 2799119
SGTC_288 1315-0019 35.1 µM 0.47108781465064 0.32794164440087 no 1120 0.318789013238907 1525 6811474
SGTC_1013 4112-3890 241 µM 0.470554947830748 0.328138937469065 no 1121 0.318979293224366 1492 705171
SGTC_1395 3486-0190 4.35 µM 0.467828099286785 0.329149298287288 no 1122 0.319953762240836 1642 6748079
SGTC_341 1486-1430 230 µM 0.467593705053288 0.329236205211743 no 1123 0.320037583710615 1461 2054753 YPL210C SRP72
SGTC_2277 7947813 106.88 µM 0.466449139993178 0.329660710881022 no 1124 0.320447022290193 1626 1246798
SGTC_430 0958-0115 16.4 µM 0.465471560541659 0.330023457433995 no 1125 0.320796899225938 1542 6833180
SGTC_3250 9135583 49.47 µM 0.464268031460952 0.330470265778342 no 1126 0.321227862500329 1611 7699353
SGTC_996 3970-0799 1.8 µM 0.463752412947865 0.330661762382478 no 1127 0.321412570443352 1612 6615648 YGL040C HEM2
SGTC_1547 harmine 94.2 µM 0.462446272088288 0.331147050983382 no 1128 0.321880661606585 1534 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_344 k064-0035 6.43 µM 0.46077513152039 0.331768366711376 no 1129 0.322479972690641 1481 5088750
SGTC_1452 4194-0072 190 µM 0.458948186054633 0.332448139169164 no 1130 0.323135687328729 1670 1343545
SGTC_1774 st048371 48.465 µM 0.458863110400036 0.33247980769372 no 1131 0.323166235511017 1501 4242727
SGTC_2560 caryophyllene 100 µM 0.457303561604857 0.333060545130834 no 1132 0.323726435050017 1549 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.457089118327279 0.333140429866712 no 1133 0.323803495677492 1520 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1939 st074455 53.6 µM 0.456767735664217 0.333260166000746 no 1134 0.323918999333084 1662 1644229
SGTC_541 4513-1321 94 µM 0.453359607913099 0.334530960915077 no 1135 0.325144908449103 1496 747515
SGTC_548 1436-0017 110 µM 0.452084446479722 0.335006921480365 no 1136 0.325604074017263 1668 9677137
SGTC_2977 9011197 71.43 µM 0.451560541406293 0.335202548621849 no 1137 0.325792800764107 1609 2704722
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.451452374348702 0.335242943974465 no 1138 0.325831771433145 1522 6708630 An antioxidant.
SGTC_684 1140-0066 328 µM 0.450551622084062 0.335579406903986 no 1139 0.326156370344887 1535 6813534
SGTC_2428 5615643 7.78 µM 0.45024123480858 0.33569537812994 no 1140 0.326268253356448 1581 2253075
SGTC_36 0335-0881 14.2 µM 0.449079303390052 0.336129654044685 no 1141 0.326687224965409 1578 23828853
SGTC_2390 9097792 176.6 µM 0.448823744671028 0.336225199380842 no 1142 0.326779404204481 1498 4497149
SGTC_3056 9094900 49.47 µM 0.448262130693331 0.336435206280996 no 1143 0.32698201377198 1475 25236784
SGTC_2287 7945887 168.79 µM 0.448127581023601 0.336485526639196 no 1144 0.327030561896995 1613 1245853
SGTC_2147 5545932 89.7195 µM 0.447878249793585 0.33657878200306 no 1145 0.327120533168343 1565 797404
SGTC_2738 aclarubicin 5.55 µM 0.447533069905984 0.336707903462788 no 1146 0.327245108048029 1595 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1262 0737-0114 49.6 µM 0.446561968291084 0.337071266725529 no 1147 0.327595680293269 1602 765919
SGTC_2716 st080858 38.6235 µM 0.445251512250704 0.337561849422227 no 1148 0.328069002084545 1594 5296050
SGTC_334 1502-1024 68.5 µM 0.444620538348308 0.337798159553352 no 1149 0.328297001239532 1569 3296216
SGTC_3071 9117417 49.47 µM 0.444601853082492 0.337805158468924 no 1150 0.328303754039292 1636 45595590 YGL055W OLE1
SGTC_545 4218-0007 221 µM 0.444596194493064 0.337807278010428 no 1151 0.32830579904783 1563 2840508
SGTC_2844 9010103 25.97 µM 0.444501175930634 0.337842869943107 no 1152 0.328340139429376 1551 2480525
SGTC_467 ro 31-8220 72.8 µM 0.444290515841256 0.337921783902852 no 1153 0.32841627865002 1622 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_431 k089-0097 107 µM 0.443186905700038 0.338335316229158 no 1154 0.3288152746676 1512 5499420
SGTC_458 nppb 133 µM 0.443148577411181 0.338349681680432 no 1155 0.328829135275865 1679 4549 A chloride channel blocker.
SGTC_3336 9143619 71.43 µM 0.442903713866401 0.338441462144302 no 1156 0.328917690510476 1595 45595730
SGTC_1252 0493-0875 34.8 µM 0.441280436689311 0.339050146100418 no 1157 0.329504993592671 1543 3960963
SGTC_340 k038-0059 454 µM 0.440321333531878 0.339409980882255 no 1158 0.329852195807738 1606 23733424
SGTC_656 4090-1979 187 µM 0.440149713529615 0.339474384457939 no 1159 0.329914338955041 1679 22330961
SGTC_3195 9113082 49.47 µM 0.438255708751142 0.340185455754097 no 1160 0.330600464507543 1660 17018038
SGTC_3203 9113543 49.47 µM 0.43780509269962 0.340354715594142 no 1161 0.330763789460696 1620 17018012
SGTC_104 0074-0074 590.992 µM 0.43760203859507 0.340430997039149 no 1162 0.330837396578336 1566 3943124
SGTC_1590 st077108 57.8 µM 0.43740873122672 0.340503622988912 no 1163 0.330907476581294 1635 5489485
SGTC_1855 st056195 39.6 µM 0.436965994845677 0.340669982180983 no 1164 0.331068004773778 1660 4028379
SGTC_2798 7813637 45.45 µM 0.436830763326324 0.340720801910321 no 1165 0.331117043466658 1621 956368
SGTC_2704 st078022 71.1 µM 0.434825621060665 0.341474669104616 no 1166 0.331844503104735 1695 54697681
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.434391039544372 0.34163814093972 no 1167 0.332002251731549 1591 616764
SGTC_297 0986-0032 24 µM 0.434064013725801 0.341761174299555 no 1168 0.332120978384207 1556 2847425
SGTC_875 0709-0210 25.7 µM 0.434006328215154 0.341782878435077 no 1169 0.332141922845386 1627 6251364
SGTC_2467 5474540 200 µM 0.432071336555525 0.342511220385253 no 1170 0.332844783263297 1530 5413519
SGTC_2414 st077232 92.9 µM 0.431118487623012 0.342870093692696 no 1171 0.333191109331594 1501 729801
SGTC_1273 0849-0096 14.1 µM 0.430677076083512 0.343036391449147 no 1172 0.333351594679391 1557 5286025
SGTC_2207 7258803 200 µM 0.4294455639709 0.343500513041843 no 1173 0.333799500549497 1629 3666799
SGTC_2497 7-hydroxyflavone 100 µM 0.428818167881967 0.34373705144288 no 1174 0.33402777815041 1651 5281894
SGTC_2262 9014885 67.46 µM 0.428615847962283 0.343813342353412 no 1175 0.334101405204015 1652 6457424
SGTC_2931 9014674 55.67 µM 0.42792163682061 0.34407516422363 no 1176 0.334354086891789 1517 2996810
SGTC_197 4544-0043 41.561 µM 0.427574602053891 0.344206076494373 no 1177 0.334480430115722 1571 896523
SGTC_2316 5844804 197.44 µM 0.426784878810221 0.344504054149538 no 1178 0.334768010592371 1711 776813
SGTC_528 3492-0019 172 µM 0.426762551508803 0.34451248007047 no 1179 0.334776142566979 1594 2869262
SGTC_3015 9080845 49.47 µM 0.424220618881436 0.345472263100495 no 1180 0.335702462476274 1709 5296973
SGTC_2178 5812956 200 µM 0.42378698300299 0.345636094808868 no 1181 0.335860586081851 1598 5403383
SGTC_869 0564-0080 44.1 µM 0.423356765414797 0.345798663630311 no 1182 0.336017491939692 1543 6843321
SGTC_2795 7780010 54.55 µM 0.422909103231022 0.345967854530496 no 1183 0.336180790406934 1591 953673
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.420926703625123 0.34671745835687 no 1184 0.336904302518125 1650 5377381
SGTC_1732 st034308 51.822 µM 0.420878348359558 0.346735750424433 no 1185 0.336921958190622 1565 830119
SGTC_1010 4112-3296 15.2 µM 0.420608043794065 0.346838009144004 no 1186 0.337020659517448 1755 704384
SGTC_2104 5389443 200 µM 0.418306419013075 0.347709186431247 no 1187 0.337861548529151 1683 2244536
SGTC_56 0957-0365 83.25 µM 0.416851509178464 0.348260293045268 no 1188 0.338393511831649 1575 6752360
SGTC_1524 corynanthine 62.1 µM 0.416198199574303 0.348507865139879 no 1189 0.338632488545996 1641 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2754 granisetron 64.02 µM 0.413416398982013 0.349562751664238 no 1190 0.339650780903668 1719 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1705 st027868 56.3335 µM 0.413311918652912 0.349602394352536 no 1191 0.339689049335338 1709 292948
SGTC_3277 9138724 49.47 µM 0.412462896147967 0.349924597445319 no 1192 0.34000008548113 1615 15943418
SGTC_3089 9117425 49.47 µM 0.411262564791345 0.350380306252771 no 1193 0.340440008120019 1544 9401657
SGTC_2397 5161689 200 µM 0.409812457430964 0.350931130492353 no 1194 0.340971763591843 1680 2259942
SGTC_120 rhodamine 6G 52.259 µM 0.408895587044033 0.351279566127988 no 1195 0.341308143835439 1582 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1201 1889-3372 45.9 µM 0.408171202527766 0.351554940344453 no 1196 0.341573994311981 1611 5392199
SGTC_861 0443-0273 110 µM 0.407025596589726 0.351990600574524 no 1197 0.341994594274044 1657 6149169
SGTC_3003 9075612 71.4286 µM 0.406151469293006 0.352323151497864 no 1198 0.342315655017164 1623 6501993
SGTC_2359 9039622 200 µM 0.406138163031528 0.35232821457383 no 1199 0.342320543193875 1683 6463596
SGTC_2121 5257820 149.641 µM 0.406119029009202 0.352335495177712 no 1200 0.342327572298077 1741 791256
SGTC_216 k038-0035 28.382 µM 0.404778491030297 0.352845712032181 no 1201 0.342820170258328 1673 4444231 YPR107C YTH1
SGTC_1829 berberine 14.4 µM 0.404267539244647 0.353040253107885 no 1202 0.343007996493727 1723 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1185 1319-0113 81.3 µM 0.403895521311018 0.353181920330434 no 1203 0.343144774959958 1671 4672763
SGTC_1824 st053723 68.6 µM 0.403374205558949 0.353380475517864 no 1204 0.343336479783956 1560 675225
SGTC_2199 6590217 200 µM 0.400127577291464 0.354617925508722 no 1205 0.344531276681546 1669 703109
SGTC_260 nsc-65238 3.989 µM 0.3995939113066 0.35482147923409 no 1206 0.344727820872457 1690 3246252
SGTC_118 0083-0097 135.343 µM 0.398109978878857 0.355387706387876 no 1207 0.345274559490255 1643 5207356
SGTC_1326 1431-2094 10.8 µM 0.395138098052722 0.356522652296936 no 1208 0.346370486807464 1591 616278
SGTC_2474 5321570 43.32 µM 0.392400884062322 0.357569105635503 no 1209 0.347381016466485 1724 2841384
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.391090821861264 0.358070329994225 no 1210 0.347865052278814 1676 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_381 3461-2219 42.7 µM 0.390577458760274 0.358266807374655 no 1211 0.348054795025303 1746 2883159
SGTC_1563 conessine 56.1 µM 0.389992498178584 0.35849073271976 no 1212 0.348271047099134 1706 441082 An anti-amoebic, histamine inhibitor.
SGTC_2650 prasterone 100 µM 0.389940137206636 0.358510779091839 no 1213 0.348290406654324 1655 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_95 0471-0001 561.058 µM 0.387439346271909 0.359468658733633 no 1214 0.349215489894301 1554 4015405
SGTC_2981 9013952 38.96 µM 0.385988509256087 0.36002477930591 no 1215 0.349752589456828 1533 2996344
SGTC_3296 9122258 64.045 µM 0.385427809314245 0.360239780765204 no 1216 0.349960241116561 1657 4730474
SGTC_925 2064-1272 59.6 µM 0.385134703509019 0.360352190343897 no 1217 0.35006880885486 1617 6815817
SGTC_2453 5731132 22.18 µM 0.384301700338209 0.360671722892929 no 1218 0.350377423946831 1787 1362040
SGTC_2918 7977171 22.06 µM 0.383569806097889 0.360952551274932 no 1219 0.35064866126204 1630 2236483
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.383505442788818 0.360977251114834 no 1220 0.350672517712678 1692 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2594 a-mangostin 100 µM 0.380862376390362 0.361992044746139 no 1221 0.351652685711687 1776 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2975 9084847 53.72 µM 0.37976575432704 0.362413373359116 no 1222 0.352059652634863 1639 27211724
SGTC_487 nimodipine 119 µM 0.379634671701637 0.362463747234871 no 1223 0.352108310000267 1727 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1421 4029-0249 71.4 µM 0.379509297693415 0.36251192956827 no 1224 0.352154850614522 1776 2894095
SGTC_2125 5246583 200 µM 0.378339242790458 0.362961696852995 no 1225 0.352589298314403 1827 835267
SGTC_3024 9090631 49.47 µM 0.376749509849591 0.363573090615347 no 1226 0.35317988286955 1786 25236383
SGTC_3100 9120536 49.47 µM 0.375224946511078 0.36415974745401 no 1227 0.35374658934993 1749 16421196
SGTC_2600 tangeritin 87.95 µM 0.374971289946465 0.364257386245728 no 1228 0.353840909364397 1578 68077 A bioactive flavone.
SGTC_2159 5658611 73.75 µM 0.374706011950837 0.364359507843517 no 1229 0.353939560305614 1751 793844
SGTC_2364 9055074 200 µM 0.372559633203603 0.365186132844379 no 1230 0.354738110603438 1610 6470630
SGTC_3223 9129970 49.47 µM 0.37180201950597 0.365478058999963 no 1231 0.355020129981313 1683 17248386
SGTC_54 0159-0055 9 µM 0.371789012348138 0.36548307164106 no 1232 0.355024972550106 1776 3319099
SGTC_2070 5230947 200 µM 0.371669928081468 0.365528964878287 no 1233 0.355069308747155 1739 2835538
SGTC_12 0849-0099 9.267 µM 0.371395859353423 0.365634594046178 no 1234 0.35517135457712 1746 6071388
SGTC_1388 3346-4487 254 µM 0.370752150606293 0.365882726690299 no 1235 0.355411071768943 1714 3345614
SGTC_2128 5255449 168.493 µM 0.370712436243985 0.36589803736216 no 1236 0.355425863275627 1633 736008
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.37049165029926 0.365983158602496 no 1237 0.355508098372816 1768 165506
SGTC_2677 mitomycin C 100 µM 0.369213945954335 0.366475890856962 no 1238 0.355984130872293 1680 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_871 0574-0004 149 µM 0.368947410969961 0.366578704846326 no 1239 0.356083461772112 1673 9551173
SGTC_59 0330-0160 1.33 µM 0.367094272292059 0.367293804355671 no 1240 0.356774349778748 1734 4293482
SGTC_254 nsc-64875 3.808 µM 0.363483052188326 0.368688643337621 no 1241 0.358122035426995 1808 56993
SGTC_1412 3909-8563 178 µM 0.363119290388657 0.368829243164166 no 1242 0.358257887534387 1789 23767530
SGTC_299 1273-0059 1.44 µM 0.360976504117002 0.369657820517338 no 1243 0.359058505765299 1712 2848077
SGTC_1779 st039427 55 µM 0.359997505850454 0.370036583534291 no 1244 0.359424499371394 1866 1124498
SGTC_470 aa-861 153 µM 0.359977869110453 0.370044182051167 no 1245 0.35943184178928 1655 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2315 7733312 200 µM 0.359446985398914 0.370249628890176 no 1246 0.359630365380334 1648 726316
SGTC_1385 3091-4834 14.1 µM 0.358057370541807 0.370787571487249 no 1247 0.360150190132966 1751 4072814
SGTC_2103 5378138 10 µM 0.356453936216617 0.371408601032808 no 1248 0.360750321534346 1736 244142
SGTC_1956 st077085 54 µM 0.355694259600686 0.371702950019966 no 1249 0.361034772219978 1664 24208685
SGTC_2663 amphotericin b 100 µM 0.355609349099889 0.371735854630689 no 1250 0.361066570593251 1701 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1340 1486-1359 257 µM 0.355532451793421 0.371765654768111 no 1251 0.361095368911273 1714 4309068
SGTC_1806 st050005 60.3 µM 0.354864503099002 0.372024538311254 no 1252 0.361345551207535 1673 5194765
SGTC_3041 9091929 49.47 µM 0.354420505462652 0.372196654930195 no 1253 0.361511884746871 1741 25236887
SGTC_1243 0416-0003 5.65 µM 0.353820320191608 0.372429358599439 no 1254 0.361736772007533 1683 2141977
SGTC_53 0973-0023 39.979 µM 0.35330943684476 0.372627474856465 no 1255 0.361928235792005 1876 674768
SGTC_289 k017-0060 526 µM 0.352561549782186 0.372917559927703 no 1256 0.362208583794046 1686 5512909
SGTC_955 1216-0110 33 µM 0.351550758450245 0.373309732927859 no 1257 0.362587599809645 1630 3619719
SGTC_1968 st069590 43.6 µM 0.350494992961324 0.373719495441459 no 1258 0.362983623590121 1782 6384066
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.350382599370693 0.373763125932658 no 1259 0.363025791719359 1679 390807
SGTC_2368 9071271 200 µM 0.350179064689122 0.373842140944239 no 1260 0.363102158634188 1642 27209959
SGTC_1074 carmofur 3.8 µM 0.350049473718537 0.373892452735341 no 1261 0.363150784449811 1716 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1704 st028805 70.8 µM 0.349644090356996 0.374049850741647 no 1262 0.363302908797975 1690 2876101
SGTC_692 k241-0027 77.8 µM 0.349231082277498 0.37421023079087 no 1263 0.363457916576999 1790 3600480
SGTC_1706 st031321 9.9705 µM 0.347993902912005 0.374690784728542 no 1264 0.363922381220511 1795 6103185
SGTC_23 0213-0011 39.996 µM 0.346736355994431 0.375179449483826 no 1265 0.364394697268049 1810 627608
SGTC_3160 9100216 49.47 µM 0.345961403048268 0.375480684972319 no 1266 0.364685860773704 1733 17191039
SGTC_2305 7443522 69.23 µM 0.345763770647204 0.375557519721933 no 1267 0.364760127256662 1780 5415886
SGTC_1690 st023502 41.2 µM 0.345407827657242 0.375695914289666 no 1268 0.364893896635973 1816 24207482
SGTC_210 3551-0445 56.827 µM 0.343689367229146 0.376364295407874 no 1269 0.36553995416845 1748 2865180 YOR207C RET1
SGTC_61 0978-8327 98.565 µM 0.3412730765667 0.377304718924509 no 1270 0.366449007185902 1741 6150059 YHR072W ERG7
SGTC_698 k064-0052 127 µM 0.341073929078023 0.377382259941598 no 1271 0.366523963651413 1767 5088751
SGTC_492 tmb-8 126 µM 0.340970264503118 0.377422625232022 no 1272 0.366562983633523 1805 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3044 9093193 49.47 µM 0.34023731496694 0.377708061977488 no 1273 0.366838909665616 1654 25236277
SGTC_1098 clofazimine 15.1 µM 0.340153457725272 0.377740723245483 no 1274 0.366870482935257 1789 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_525 k781-2675 26.7 µM 0.340089938853735 0.37776546357364 no 1275 0.366894399161076 1732 3651118 YDL195W SEC31
SGTC_324 1315-0088 19.6 µM 0.337978572514378 0.378588116483595 no 1276 0.367689667634632 1755 6787421
SGTC_1506 4226-2149 212 µM 0.337554224493728 0.378753522010194 no 1277 0.367849571423077 1766 991114
SGTC_678 1218-2179 85.9 µM 0.337301417124967 0.37885207370555 no 1278 0.367944845761964 1756 6820081 YOR116C RPO31
SGTC_1545 lovastatin 49.4 µM 0.336260911457219 0.379257776065803 no 1279 0.368337061775693 1744 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1001 4048-4355 44.4 µM 0.336029576301283 0.379347993778141 no 1280 0.368424281648388 1690 21824233
SGTC_74 000s-0487 160.283 µM 0.335376310112275 0.379602794585312 no 1281 0.368670618004754 1761 677548
SGTC_2948 9070189 9.45 µM 0.33444771336044 0.379965075661971 no 1282 0.369020870036049 1851 6473636 YDL196W YDL196W
SGTC_2669 eugenol 100 µM 0.331418497227886 0.38114761955332 no 1283 0.370164197437728 1840 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_77 0828-0286 12.516 µM 0.327144218863308 0.382818097454502 no 1284 0.37177940418644 1686 745345
SGTC_699 0375-0592 111 µM 0.325765621698244 0.383357349146001 no 1285 0.372300845483539 1869 762578
SGTC_2213 7173844 200 µM 0.325338622458266 0.3835244199537 no 1286 0.372462401446291 1743 892728
SGTC_1632 st005650 90 µM 0.325139102206142 0.383602493115583 no 1287 0.372537898003256 1740 2759605
SGTC_3342 9147791 14.508 µM 0.324919023997065 0.383688616178784 no 1288 0.372621179175325 1745 1838168
SGTC_845 0330-0138 4.51 µM 0.323455993967776 0.384261288648284 no 1289 0.373174964739274 1848 9039800
SGTC_813 k007-0158 173 µM 0.322914174136314 0.384473436874891 no 1290 0.373380120744015 1826 6523916
SGTC_3142 9086498 49.47 µM 0.322602563554663 0.384595462912702 no 1291 0.373498126010341 1887 25236367
SGTC_897 1000-0139 31.4 µM 0.32253576568578 0.384621622304157 no 1292 0.37352342355168 1861 6151020
SGTC_82 0054-0107 293.755 µM 0.321253099324882 0.385124042064463 no 1293 0.374009297719896 1865 3104697
SGTC_1678 st019265 80.2 µM 0.320674057512667 0.385350915697353 no 1294 0.374228704474577 1902 5367020
SGTC_3096 9117468 49.47 µM 0.320362478609345 0.385473011273373 no 1295 0.374346782789537 1812 41316311
SGTC_2015 5119600 184 µM 0.320277146788187 0.385506451454438 no 1296 0.374379122843093 1852 2828786
SGTC_1075 aripiprazole 15.2 µM 0.315716194919448 0.387295048397544 no 1297 0.376108966601259 1737 60795 An atypical antipschotic. YIL048W NEO1
SGTC_261 5-fluorouridine 15.376 µM 0.315406275306132 0.387416672042492 no 1298 0.376226601408147 1839 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2861 9024595 19.48 µM 0.314094045419021 0.387931760740446 no 1299 0.376724805962011 1825 16482810
SGTC_647 0140-0236 81 µM 0.313912506218122 0.388003035750154 no 1300 0.376793745788913 1791 990837
SGTC_3313 9133968 57.047 µM 0.313752323634737 0.388065928965327 no 1301 0.376854578665994 1788 1494643
SGTC_2531 methyl deoxycholate 70.07 µM 0.313478855546205 0.388173308766811 no 1302 0.376958441282622 1711 16667744 Haematoxylin.
SGTC_2913 7966556 36.57 µM 0.311618060029103 0.388904194132826 no 1303 0.377665403652929 1850 2976516
SGTC_2998 9066762 71.4286 µM 0.310651322769394 0.389284065723034 no 1304 0.378032853112953 1863 4945196
SGTC_1071 trifluoperazine 6.31 µM 0.310229559837682 0.389449827237292 no 1305 0.378193196584139 1845 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3161 9100388 49.47 µM 0.308595173586728 0.390092364437231 no 1306 0.378814746355877 1811 25236368
SGTC_1758 st042942 75.2445 µM 0.306879159951569 0.390767315627268 no 1307 0.379467676077563 1870 669317
SGTC_48 0382-0018 55 µM 0.306431524579298 0.390943436067374 no 1308 0.379638054454358 1890 762596
SGTC_2847 9005661 71.43 µM 0.304827334687475 0.391574781989734 no 1309 0.38024883081072 1807 2991449
SGTC_452 diindolylmethane 8 µM 0.304141539726619 0.391844771134436 no 1310 0.380510030381707 1811 3071 Inhibits expression of several cancer promoting factors.
SGTC_2274 7947094 46.08 µM 0.304115826108315 0.391854895287607 no 1311 0.380519825019633 1732 2971028
SGTC_2828 7998861 71.43 µM 0.304109177434536 0.391857513063811 no 1312 0.380522357594865 1902 2988188
SGTC_1307 1187-1599 12.2 µM 0.303986651941635 0.391905755789634 no 1313 0.380569030229586 1757 1538471
SGTC_300 r073-0011 5.04 µM 0.303481204843456 0.392104786187026 no 1314 0.380761584432568 1842 2735780
SGTC_3205 9113483 49.47 µM 0.301941431591338 0.392711278009305 no 1315 0.381348355507201 1882 17018033
SGTC_954 1189-0853 2.85 µM 0.301049238759244 0.393062817705378 no 1316 0.381688473980152 1812 2828194
SGTC_2096 5468907 200 µM 0.299752721707572 0.393573823675088 no 1317 0.382182890236015 1901 759785
SGTC_1381 2324-0066 62.1 µM 0.299744823674357 0.393576937148795 no 1318 0.382185902676588 1792 10885928
SGTC_2763 lisinopril 49.32 µM 0.298668029495962 0.394001482446277 no 1319 0.382596676490722 1891 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_220 paclitaxel 373.376 µM 0.296968199762975 0.394671926872791 no 1320 0.383245393714016 1847 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1444 4112-3581 28 µM 0.295489938430858 0.395255234401041 no 1321 0.383809818680033 1806 2877249
SGTC_3094 9117742 49.47 µM 0.293004913922482 0.396236329346237 no 1322 0.384759197843544 1723 17149698
SGTC_644 1498-1197 63.3 µM 0.292558542195912 0.396412628049904 no 1323 0.384929803187934 1851 6741615
SGTC_1784 st039334 36.3 µM 0.290384633157253 0.397271535995799 no 1324 0.385760999223019 1897 3496984
SGTC_2591 skatole 100 µM 0.289964727408312 0.397437497640403 no 1325 0.385921611150393 1786 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2978 9011784 42.97 µM 0.289280956250272 0.397707787977659 no 1326 0.386183192167158 1950 2994934
SGTC_951 1171-0579 82.7 µM 0.28775692354701 0.398310404841612 no 1327 0.386766406632382 1744 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3075 9116269 49.47 µM 0.286988650536204 0.398614279281421 no 1328 0.387060505218383 1811 17015205 YNL244C SUI1
SGTC_2681 menadione 3.18 µM 0.286437136623654 0.398832457077565 no 1329 0.387271667380389 1824 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2204 7233102 200 µM 0.286309782814796 0.398882842484272 no 1330 0.387320433007223 1861 2172480
SGTC_2345 9052315 157.45 µM 0.284876328072559 0.399450080938972 no 1331 0.387869446163236 1785 6469265
SGTC_920 mycophenolic acid 780.421 nM 0.28447736493471 0.399607994156592 no 1332 0.388022288977189 1766 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_870 0573-2213 57.6 µM 0.284449055387172 0.399619199955834 no 1333 0.38803313502682 1751 3916321
SGTC_1805 st050013 60.3 µM 0.282792710017794 0.400274976609036 no 1334 0.388667871448476 1885 4037144
SGTC_2944 9067346 25.62 µM 0.279142986643933 0.401720957392418 no 1335 0.39006754756768 1861 6473075
SGTC_1085 doxorubicin 7.67 µM 0.279084018387905 0.401744331081944 no 1336 0.3900901737684 1906 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2331 7980721 200 µM 0.278423220411984 0.402006280546927 no 1337 0.39034374830733 1903 2981221
SGTC_857 0438-0306 1.35 µM 0.277689031733488 0.402297374728159 no 1338 0.390625540499531 1847 4686136
SGTC_1819 st053448 58.6 µM 0.275927623171209 0.402995965994322 no 1339 0.391301828492065 1850 2857616
SGTC_3095 9117207 49.47 µM 0.274112894848267 0.403716028347859 no 1340 0.391998932289315 1956 17015229
SGTC_959 1222-0044 107 µM 0.273744321627906 0.403862313728711 no 1341 0.392140557245595 1977 6083612
SGTC_1756 st041558 35.5 µM 0.273207357383377 0.404075456960819 no 1342 0.39234691234057 1986 3955792
SGTC_2924 9010168 62.78 µM 0.272365243985811 0.404409783800169 no 1343 0.392670597054915 1825 2993929
SGTC_2966 9084041 48.03 µM 0.271803273030923 0.404632930344016 no 1344 0.392886644211117 1642 17741380
SGTC_1065 prochlorperazine maleate 2.48 µM 0.271014396173192 0.404946228650854 no 1345 0.393189979967789 1826 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_874 0599-0792 117 µM 0.270008261505367 0.405345898154637 no 1346 0.393576948912864 1988 765305
SGTC_2845 9003024 42.97 µM 0.269162799365498 0.405681819641617 no 1347 0.393902202988798 1905 2990173
SGTC_3335 9143315 29.6265 µM 0.268611481546915 0.405900908284706 no 1348 0.394114337965365 1810 4899691
SGTC_2696 st077691 74.316 µM 0.267718530308247 0.406255821417975 no 1349 0.394457992597325 1841 757133
SGTC_2871 9038510 12.99 µM 0.267355207986716 0.406400249873301 no 1350 0.394597841678827 1978 4945164
SGTC_2051 5263410 176 µM 0.263425456221403 0.40796322080412 no 1351 0.396111336025668 1945 227584
SGTC_3022 9087993 49.47 µM 0.263263968313123 0.408027480533153 no 1352 0.396173564738578 1884 17173644
SGTC_3308 9128332 17.569 µM 0.263233862055986 0.408039460774506 no 1353 0.396185166355747 1954 17332805 YDL196W YDL196W
SGTC_802 4112-3352 742 µM 0.262772691931317 0.408222985836177 no 1354 0.396362892367678 1947 704594
SGTC_1190 1486-1332 13 µM 0.260231907346503 0.409234464338331 no 1355 0.397342446688765 1853 4150046
SGTC_143 4032-1194 15.74 µM 0.259853836022133 0.409385025204642 no 1356 0.397488260884652 1812 1806963
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.259779338198467 0.409414694350152 no 1357 0.397516994826004 1820 688803
SGTC_1562 morin hydrate 59.1 µM 0.25790512789623 0.410161278628966 no 1358 0.398240063611754 1846 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2938 9059746 27.26 µM 0.25716092196247 0.410457820632581 no 1359 0.398527274746091 1881 6471769
SGTC_3231 9132313 49.47 µM 0.256894165613375 0.410564126887257 no 1360 0.398630237321479 1875 4905967
SGTC_1178 0988-0033 191 µM 0.256628183634833 0.410670131086401 no 1361 0.398732908030827 1915 5392207
SGTC_2099 5377090 177.372 µM 0.256158675668627 0.410857264255421 no 1362 0.398914158145925 1828 2243829
SGTC_2661 dactinomycin 12.96 µM 0.254933791226421 0.411345565461748 no 1363 0.399387118352592 1875 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3131 9127911 49.47 µM 0.254705455328326 0.411436606971352 no 1364 0.399475301222606 1886 45595681
SGTC_796 1234-0020 70.7 µM 0.254565805336341 0.411492290212235 no 1365 0.399529236299792 1811 46495034
SGTC_1148 3909-7663 27.7 µM 0.252904742960019 0.412154749159571 no 1366 0.400170912122395 1969 4084526
SGTC_1116 jasmonic acid 1.58368 µM 0.252634398709941 0.412262590626681 no 1367 0.400275372870344 1931 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_586 0957-0265 8.15 µM 0.251295301101687 0.412796859865635 no 1368 0.400792903904873 1987 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_938 3126-1755 342 µM 0.249717304083794 0.413426651819902 no 1369 0.401402987675927 2002 1777771
SGTC_2012 4023501 200 µM 0.248367301155938 0.413965626319815 no 1370 0.401925115484296 1821 3477460
SGTC_2586 curcumin 80 µM 0.2483433113049 0.413975205484848 no 1371 0.401934395397143 1940 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2884 9058502 51.95 µM 0.248337993703669 0.413977328813832 no 1372 0.401936452394307 1833 6471554
SGTC_1502 4534-4282 27.7 µM 0.246626399958166 0.414660902013466 no 1373 0.402598685663126 1874 3278949
SGTC_363 0455-0021 3.06 µM 0.246544687389236 0.41469354271242 no 1374 0.402630308105932 1854 4597466
SGTC_2752 diclazuril 33.15 µM 0.245925689827778 0.414940825049892 no 1375 0.402869878405685 1985 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_889 0919-1524 82.7 µM 0.245514408867403 0.415105145660751 no 1376 0.403029076431342 1851 3905452
SGTC_2057 5236571 38.335 µM 0.245411850543383 0.415146123483795 no 1377 0.40306877706084 1970 54684039 YBR257W POP4
SGTC_2041 5107442 45.335 µM 0.244820700766505 0.41538233907472 no 1378 0.403297632348843 1973 793005
SGTC_1149 3909-7961 23.3 µM 0.243762148129949 0.415805399001921 no 1379 0.40370751876588 1805 735261
SGTC_2030 5175110 200 µM 0.243004990238431 0.41610806375271 no 1380 0.404000765828387 1926 2831986
SGTC_1525 8-methoxypsoralen 92.5 µM 0.241514919019635 0.416703846939928 no 1381 0.404578027479901 2023 4114 Related to psoralen; DNA damaging agent.
SGTC_2958 9077254 16.72 µM 0.2411397669368 0.416853876225345 no 1382 0.404723396215127 1874 16457351
SGTC_1130 3454-2858 15.9 µM 0.24047045406919 0.417121575151383 no 1383 0.404982782789476 1789 715628 YIL048W NEO1
SGTC_2174 5790901 200 µM 0.238925175086154 0.417739772783239 no 1384 0.405581801956776 1877 786020
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.238652527682465 0.417848868072291 no 1385 0.405687515266517 2011 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2077 5212015 200 µM 0.23769170113931 0.418233377054068 no 1386 0.406060110382056 1957 780900
SGTC_873 0591-4978 488 µM 0.235956778017446 0.41892786610641 no 1387 0.40673310468835 2048 3305145
SGTC_222 nsc-310342 10.666 µM 0.235182474140974 0.419237901340516 no 1388 0.407033554078394 1998 432556
SGTC_1832 st054113 55 µM 0.235167358129232 0.41924395436868 no 1389 0.407039420016437 2018 1251267
SGTC_2491 paeonol 100 µM 0.231598514798933 0.420673587369208 no 1390 0.408424930585555 1873 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1984 st072354 53.1 µM 0.231167241541293 0.420846421194245 no 1391 0.40859243912621 1919 5762938
SGTC_2082 5219693 150 µM 0.229492023624788 0.421517913361861 no 1392 0.40924325972182 1892 2834649
SGTC_31 0508-1974 57.237 µM 0.228795534425359 0.421797160487919 no 1393 0.409513918876669 1971 6810525
SGTC_1014 4130-3005 69.3 µM 0.228419109128255 0.421948099068365 no 1394 0.409660217576488 1850 743608
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.227161163743036 0.422452591616489 no 1395 0.410149212571121 1932 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1411 3909-8223 150 µM 0.227094053037065 0.42247950960353 no 1396 0.410175304122894 2010 X1411
SGTC_1723 st034307 2.5525 µM 0.226863353758822 0.422572045442021 no 1397 0.410264999285176 1875 867466
SGTC_2110 5483698 200 µM 0.225299363092845 0.423199490513605 no 1398 0.410873197556413 1903 2848765 YHR062C RPP1
SGTC_624 k048-0052 28 µM 0.224467078649294 0.423533467671958 no 1399 0.411196940387543 1919 6835531
SGTC_1810 st050138 53 µM 0.223989747306855 0.423725034885488 no 1400 0.411382640515082 2023 3444541
SGTC_3300 9124615 50.48 µM 0.221629184562286 0.424672662846852 no 1401 0.4123012807193 1978 24824903
SGTC_2643 anethole 100 µM 0.2198347350906 0.425393321106929 no 1402 0.412999933298345 1939 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1263 0774-1208 64.8 µM 0.217474311108905 0.426341656390951 no 1403 0.413919362349344 2053 906585
SGTC_3254 9136651 49.47 µM 0.217183068072975 0.426458697231436 no 1404 0.414032839746988 1907 16454030
SGTC_1752 st044819 83.042 µM 0.216568545748125 0.426705674449817 no 1405 0.414272300408893 1880 441209 YML126C ERG13
SGTC_1434 4073-0095 163 µM 0.216421493857972 0.426764779036163 no 1406 0.414329606787548 2008 24133745
SGTC_1518 st038567 90.8 µM 0.215796313215821 0.42701607631848 no 1407 0.414573261121707 2017 77966
SGTC_207 4185-0010 4.486 µM 0.213737042092625 0.427844028804262 no 1408 0.415376061678769 2027 3761753
SGTC_1024 4507-0395 26 µM 0.213327693108441 0.428008650025258 no 1409 0.415535687343458 1923 4201836
SGTC_2143 5623677 140.463 µM 0.212715920380148 0.428254700059785 no 1410 0.415774274137722 2014 5375313
SGTC_352 k048-0007 5.11 µM 0.212137369696864 0.428487414122688 no 1411 0.415999933150768 2020 6811911
SGTC_704 1310-0270 142 µM 0.21094129762357 0.428968596440897 no 1412 0.41646653912332 1876 5718033
SGTC_628 1636-0253 16 µM 0.210922637391043 0.428976104330133 no 1413 0.41647381969929 2034 4456143
SGTC_253 dyclonine 31.25 µM 0.207992399335503 0.430155394061553 no 1414 0.417617451016767 1970 3180 An oral anasthetic.
SGTC_2336 9001819 198.65 µM 0.207523923333227 0.4303439927604 no 1415 0.417800355599155 1990 2989602
SGTC_2593 nobiletin 86.24 µM 0.207366685934725 0.430407296832128 no 1416 0.417861748944315 1886 72344 An anti-infammatory.
SGTC_1450 4112-4260 37.6 µM 0.205188612923207 0.431284376400512 no 1417 0.418712382871683 2042 1633175
SGTC_3255 9139072 49.47 µM 0.204801696248705 0.431440217915968 no 1418 0.418863530844983 1945 17646060
SGTC_1377 2944-0135 198 µM 0.204734851763544 0.431467142484342 no 1419 0.418889644679918 1933 1894137
SGTC_2011 4012611 177 µM 0.204719719708121 0.431473237632129 no 1420 0.418895556301691 1900 2049887
SGTC_1744 st037937 38.9 µM 0.204604535130878 0.431519634178577 no 1421 0.418940555921195 1992 1016152
SGTC_2000 st075254 36.4 µM 0.204168931053245 0.431695104790079 no 1422 0.419110744692913 1932 17234175
SGTC_1312 1218-2183 165 µM 0.203305439081772 0.432042977577541 no 1423 0.419448152266448 2046 6744073
SGTC_3093 9117344 49.47 µM 0.202938619109665 0.432190773359237 no 1424 0.41959150429891 1961 24824913
SGTC_2067 5224629 34.075 µM 0.202814982669448 0.432240589973566 no 1425 0.419639823416582 1881 2835000
SGTC_1037 k284-1091 78.7 µM 0.201591137738602 0.432733769655585 no 1426 0.420118187026119 1906 3334711
SGTC_898 1000-0849 28.3 µM 0.201551943266763 0.432749565808573 no 1427 0.420133508902501 2062 6751807
SGTC_1920 st075728 45.7 µM 0.201473797044569 0.432781060613675 no 1428 0.420164058131972 2077 3400306
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.201437098059577 0.432795851333734 no 1429 0.420178404809953 1959 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2183 6420625 130.508 µM 0.201118597107862 0.432924220100961 no 1430 0.420302920351511 1989 2897619
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.200657622380517 0.43311002409594 no 1431 0.420483149062707 2067 1241132 A phosphatase inhibitor.
SGTC_3076 9116187 49.47 µM 0.199773157189431 0.433466564763326 no 1432 0.420828997796135 2057 27241210
SGTC_2298 7976326 193.81 µM 0.198782532738576 0.43386596403867 no 1433 0.42121643008709 2021 2235818
SGTC_1974 st069448 26.9 µM 0.198778907472406 0.433867425795225 no 1434 0.421217848065626 2072 6323587 YNR016C ACC1
SGTC_321 4534-3890 65.3 µM 0.198657523235618 0.433916370090028 no 1435 0.42126532661546 2061 699746
SGTC_1856 st057054 55.7 µM 0.198281524657083 0.434067985867223 no 1436 0.421412402951982 2071 1266018
SGTC_349 k015-0014 24 µM 0.197516246383615 0.434376602771398 no 1437 0.421711784542672 1891 2196908
SGTC_567 1080-0542 68.4 µM 0.195900073799239 0.435028494515682 no 1438 0.422344189751997 2060 5950415
SGTC_2675 theaflavin digallate 100 µM 0.19541877962165 0.435222661278166 no 1439 0.422532558003379 1989 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1635 st007035 42.4 µM 0.195369559639155 0.435242518798148 no 1440 0.422551822651549 2020 3716403
SGTC_1619 st003326 88.7 µM 0.195248943453669 0.435291181397593 no 1441 0.42259903247985 2045 2849032
SGTC_3086 9117350 49.47 µM 0.195115917647453 0.435344851794856 no 1442 0.422651100790175 2032 2679265
SGTC_706 4262-0057 46.9 µM 0.194871873254315 0.435443316685011 no 1443 0.422746626966026 1950 883298
SGTC_1546 5-methoxyflavanone 78.7 µM 0.194724063456716 0.435502955631725 no 1444 0.422804486291268 2085 147795
SGTC_1462 k081-0014 26.5 µM 0.191118745554136 0.436958096202594 no 1445 0.424216280751182 2023 3270634
SGTC_1357 1503-1303 39.5 µM 0.191091141586875 0.436969240742944 no 1446 0.424227093873443 1972 292895
SGTC_231 b-estradiol 524 µM 0.188616798510494 0.437968408584019 no 1447 0.425196582915561 1943 450 A steroid.
SGTC_1995 st072814 61.1 µM 0.187284900405505 0.438506408367648 no 1448 0.425718630627039 1919 5769371
SGTC_1628 st004252 77.7 µM 0.186920699226084 0.438653541670494 no 1449 0.425861404795197 2054 692968
SGTC_2323 6148992 148.28 µM 0.18549400121712 0.439229993571754 no 1450 0.42642079247963 1943 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1614 st002383 48.6 µM 0.182893762328663 0.440280940904538 no 1451 0.427440688644101 2123 1947235
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.181304457070183 0.440923503487163 no 1452 0.428064303885291 1918 803109
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.181065408603282 0.441020165255228 no 1453 0.428158117856931 2060 5282309
SGTC_1197 1601-0112 267 µM 0.179797495968239 0.441532917706645 no 1454 0.428655774755218 1934 7350313
SGTC_176 1486-1328 72.834 µM 0.179359470733946 0.441710080896538 no 1455 0.428827726479472 1946 22310231
SGTC_592 k241-0073 46.5 µM 0.177495604406927 0.442464068124889 no 1456 0.429559558796978 2092 4230158
SGTC_779 1360-0071 233 µM 0.177168583053396 0.442596379186651 no 1457 0.429687986175492 2126 7566
SGTC_2860 9025725 38.96 µM 0.17492367715635 0.44350482797869 no 1458 0.430569802712085 1898 40546248
SGTC_2522 biochanin a 4.94 µM 0.174101157050328 0.443837752785175 no 1459 0.430892981946605 2056 5280373 A possible chelator.
SGTC_87 0100-0052 35.5 µM 0.172899146217816 0.444324352211505 no 1460 0.431365351383268 2023 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2912 7964298 10.93 µM 0.172845053951044 0.444346251884974 no 1461 0.431386611020675 1975 2975850
SGTC_213 1246-0773 967 nM 0.172653003858174 0.444424006225724 no 1462 0.431462093199789 2045 6251622
SGTC_1700 st030840 7.9285 µM 0.171776257488749 0.44477899717838 no 1463 0.431806715916631 2119 5499307
SGTC_3059 1327-0034 3 µM 0.170133702633743 0.445444179803782 no 1464 0.432452494504714 1971 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2507 purpurin 79.67 µM 0.169898705431598 0.445539358822617 no 1465 0.432544899618216 1895 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2915 7971052 15.16 µM 0.169668715407954 0.445632512863778 no 1466 0.432635339391719 2108 5741558
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.168103529109418 0.446266547773097 no 1467 0.433250916517068 2084 368090
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.16810011634423 0.446267930386892 no 1468 0.433252258911923 2008 115019
SGTC_2995 9067767 71.4286 µM 0.167224439808359 0.446622714824223 no 1469 0.433596727493923 1999 11673567
SGTC_538 2922-0838 53.3 µM 0.167086391758661 0.446678649542429 no 1470 0.43365103664877 2127 777039
SGTC_336 4111-0029 111 µM 0.165914995648381 0.447153321874911 no 1471 0.434111923118814 1989 3131175
SGTC_2014 4013930 200 µM 0.165188474119274 0.447447760516933 no 1472 0.434397818479893 2157 64556
SGTC_2743 auranofin 4.32 µM 0.164272414430435 0.447819054882018 no 1473 0.434758348381529 2074 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_80 0159-0065 512.242 µM 0.164117802732237 0.447881726116832 no 1474 0.434819203641044 2125 1548079
SGTC_1101 ebselen 5.29 µM 0.163844005339096 0.447992711988408 no 1475 0.434926974251075 2141 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3106 9121286 49.47 µM 0.163726527475534 0.448040333789428 no 1476 0.43497321671831 2107 15943471
SGTC_1942 st076330 65.2 µM 0.163493411282995 0.44813483391918 no 1477 0.435064980195201 2068 24208414
SGTC_3222 9128301 49.47 µM 0.162912150416305 0.448370476979871 no 1478 0.43529380199444 2033 4911358
SGTC_347 4534-1311 26.2 µM 0.162615426249433 0.448490775937634 no 1479 0.435410620139985 2076 2862016
SGTC_153 4077-0274 519.67 µM 0.162321631328783 0.4486098919767 no 1480 0.43552629061628 2127 3121976
SGTC_3333 9141820 12.094 µM 0.162132897451477 0.448686414573086 no 1481 0.435600600248948 1990 1939433
SGTC_809 3998-0021 90 µM 0.160788398309566 0.44923160000027 no 1482 0.436130031574858 2141 715485
SGTC_438 sphingosine 6.67 µM 0.159898771245135 0.449592390600192 no 1483 0.436480408235209 1857 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1026 k007-1105 30.6 µM 0.158960877425384 0.449972801032797 no 1484 0.436849848565881 1977 7066794
SGTC_3069 9117009 49.47 µM 0.158944496477988 0.449979445566784 no 1485 0.436856301580496 2139 41904981
SGTC_1803 st050068 52.4 µM 0.158075007680549 0.450332152687888 no 1486 0.437198846984426 2118 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2692 st077426 47.7 µM 0.157708287485324 0.450480924088008 no 1487 0.437343334877861 2103 25238571
SGTC_477 mead ethanolamide 10 µM 0.157413729998766 0.450600425491376 no 1488 0.43745939668996 2117 16061185
SGTC_1310 1188-0297 994 nM 0.157070634428061 0.450739624347184 no 1489 0.437594590306862 2057 1588352
SGTC_1249 0481-0015 10.2 µM 0.155424517727329 0.45140756177315 no 1490 0.438243328336218 2022 4227577
SGTC_2833 9001315 45.46 µM 0.15532759595604 0.451446893595434 no 1491 0.438281530600126 1977 2989378
SGTC_113 0099-0221 2.5 µM 0.155086143512905 0.451544879479053 no 1492 0.438376702945428 2119 89219
SGTC_663 1486-0733 13.9 µM 0.155012467805662 0.451574779036856 no 1493 0.438405744114634 2028 722445 YPR165W RHO1
SGTC_3286 9117135 37.221 µM 0.154538851479716 0.451766991666347 no 1494 0.438592440046431 1975 3438150
SGTC_2837 9008476 45.46 µM 0.153155291422485 0.452328560805392 no 1495 0.439137906952427 2056 2992805
SGTC_1295 1013-0063 9.78 µM 0.152979837010247 0.452399782320902 no 1496 0.439207087925952 2145 6826038
SGTC_752 1896-0090 130 µM 0.152067990973931 0.452769948988839 no 1497 0.439566655029158 2093 772567
SGTC_1465 k213-0056 144 µM 0.151391486363097 0.453044604633394 no 1498 0.43983345247873 1998 24048857 YMR208W ERG12
SGTC_2232 chlorophetanol 41.5365 µM 0.150642824929612 0.453348581571998 no 1499 0.440128738724324 2139 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2627 acetyl isogambogic acid 100 µM 0.150249084790647 0.453508461775757 no 1500 0.440284050664805 1997 6857789 A caspase activator and apoptosis inducer.
SGTC_2588 indole-3-carbinol 100 µM 0.149770452157666 0.453702823157523 no 1501 0.440472861067185 2142 3712 Induces cell cycle arrest.
SGTC_290 2043-6722 48.1 µM 0.149088678207661 0.453979694555432 no 1502 0.440741829763345 2102 773758 YLR208W SEC13
SGTC_1888 azatryptophan 97.5 µM 0.148676946889495 0.454146911294204 no 1503 0.440904276375986 2034 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3011 9081274 71.4286 µM 0.148196548225098 0.454342026224083 no 1504 0.441093827928677 2031 6625322
SGTC_744 1594-0068 283 µM 0.148036554847822 0.454407010319538 no 1505 0.441156959730389 2046 668392
SGTC_3275 9138069 49.47 µM 0.147557409527949 0.454601630825687 no 1506 0.441346034665141 2058 17617007
SGTC_402 epigallocatechin gallate 10 µM 0.147167003759581 0.454760214927652 no 1507 0.441500102082329 1998 65064 An antioxidant.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.145707584542547 0.455353099451243 no 1508 0.442076116838317 2000 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2131 toluylene red 5.2905 µM 0.145454545098443 0.455455906092916 no 1509 0.442176000879312 2021 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1211 1056-0033 32.3 µM 0.145153947535085 0.455578038857197 no 1510 0.44229466264874 2160 6741922
SGTC_615 k087-0205 167 µM 0.144956187661327 0.455658390967193 no 1511 0.442372731763014 2045 9642773
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.143198699612189 0.456372557872302 no 1512 0.443066628398801 2009 688669
SGTC_1343 1487-0095 224 µM 0.14287385395463 0.456504576559404 no 1513 0.443194904110362 2162 4560101 YGL055W OLE1
SGTC_2744 captopril 92.04 µM 0.142537059792045 0.456641456240211 no 1514 0.443327904357803 2159 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2825 7998094 58.44 µM 0.142459064623979 0.45667315572375 no 1515 0.44335870561461 2078 2987815
SGTC_1341 1486-1360 280 µM 0.140005884575255 0.457670338461882 no 1516 0.444327670483353 2011 3976547
SGTC_1053 3366-3204 134 µM 0.139351805791645 0.457936257432742 no 1517 0.44458607704575 2017 3632071 YPR165W RHO1
SGTC_2456 5770359 74.46 µM 0.137581797868384 0.458655957012083 no 1518 0.445285470952955 2136 3118787
SGTC_888 0916-0002 6.97 µM 0.137578083275667 0.458657467538965 no 1519 0.445286938902246 2139 2802138 YIL048W NEO1
SGTC_2516 gossypol 71.55 µM 0.137379451276493 0.45873824145549 no 1520 0.445365436272307 2140 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2583 asiatic acid 100 µM 0.136367760517558 0.45914967295948 no 1521 0.445765279468977 2095 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2565 isoliquiritigenin 100 µM 0.135528176985746 0.459491145632998 no 1522 0.44609714388044 1888 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_255 tunicamycin 200.472 nM 0.134683915188346 0.459834551171699 no 1523 0.446430895562234 2162 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3029 9088683 49.47 µM 0.134431962769841 0.459937039247772 no 1524 0.446530504191391 2099 25236615
SGTC_822 1487-0950 154 µM 0.134272933024101 0.460001730026123 no 1525 0.446593377859213 2184 1958375
SGTC_1359 1582-0056 520 nM 0.134012589984451 0.460107635730381 no 1526 0.446696309436413 2121 3661189
SGTC_3153 9100258 49.47 µM 0.133312361742836 0.460392497641168 no 1527 0.446973175803184 2024 25236848
SGTC_526 4469-0568 170 µM 0.133311477426249 0.460392857405484 no 1528 0.446973525473432 2011 2901964
SGTC_1714 st033236 13.627 µM 0.132528977041053 0.460711212763175 no 1529 0.447282952400098 2130 2916566
SGTC_502 l-744,832 89.3 µM 0.132501673251073 0.460722321594194 no 1530 0.44729374981593 2185 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1360 1598-0022 39.8 µM 0.132361818657966 0.460779223370877 no 1531 0.447349056603648 2126 761525
SGTC_45 0kpi-0036 14.9 µM 0.132199050223239 0.460845448972282 no 1532 0.447413426170302 2087 2795021
SGTC_459 nigericin 15.3 µM 0.131725014407689 0.461038326129084 no 1533 0.447600899641354 2089 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1797 st048695 56.8 µM 0.131706985587895 0.461045661932182 no 1534 0.447608029978306 2181 592262 YIL048W NEO1
SGTC_701 4424-0219 185 µM 0.128336861098656 0.462417172600575 no 1535 0.448941197672514 2187 2911779
SGTC_3054 9094397 49.47 µM 0.127748835837674 0.462656522455306 no 1536 0.449173870635421 2109 2598354
SGTC_3032 9089427 49.47 µM 0.127430967168594 0.462785913382556 no 1537 0.449299653884262 2077 17173707
SGTC_2709 st078560 56 µM 0.126468217701173 0.463177832048917 no 1538 0.449680652807432 2184 17250903
SGTC_2492 derrusnin 100 µM 0.125383703186358 0.463619361952312 no 1539 0.450109894634197 2086 1715307 Part of coumarin class of compounds.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.12413247617703 0.464128819852581 no 1540 0.450605192370092 2113 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_66 0109-0187 42.4 µM 0.123294260753955 0.464470146165198 no 1541 0.450937042706974 2214 759417
SGTC_2968 9090663 33.37 µM 0.122191538806418 0.464919220897564 no 1542 0.451373663648154 2044 25236811
SGTC_399 oxolinic acid 75 µM 0.121994799064268 0.464999346304843 no 1543 0.45145156862541 2063 4628 A DNA gyrase inhibitor.
SGTC_544 k015-0020 52.4 µM 0.121859077251475 0.465054622011679 no 1544 0.451505312821078 2093 3008304
SGTC_629 3448-6466 76.7 µM 0.12161055215955 0.465155841093323 no 1545 0.451603728053753 2153 573744
SGTC_1155 4088-0394 48.2 µM 0.120582982028814 0.465574372815571 no 1546 0.452010674423763 2029 2326248
SGTC_3184 9108758 49.47 µM 0.119533622169761 0.466001818843664 no 1547 0.452426302171636 2180 902885
SGTC_1282 0886-0010 32.4 µM 0.118680419337168 0.466349391242342 no 1548 0.452764274999817 2183 2836211 YNL267W PIK1
SGTC_840 0245-0196 390 µM 0.118315126595938 0.466498209761734 no 1549 0.452908986146411 2175 3827528
SGTC_721 1187-1332 279 µM 0.117649424215562 0.46676942576589 no 1550 0.453172720994274 2153 25730
SGTC_1611 st001856 99.4 µM 0.117215921508232 0.466946048838597 no 1551 0.453344475176975 2029 647478
SGTC_2187 6125751 200 µM 0.115225829288495 0.467756959994175 no 1552 0.454133063107421 2151 874498
SGTC_677 0929-0063 136 µM 0.11459988041083 0.468012045810977 no 1553 0.454381137251929 2207 1539583
SGTC_1851 st056236 18.9 µM 0.113676880076684 0.468388209558358 no 1554 0.454746970361036 2215 5393171
SGTC_633 0437-0093 97.7 µM 0.11262334373979 0.468817607016893 no 1555 0.455164588583369 2176 2831118
SGTC_2700 st077718 96.8 µM 0.111970828678881 0.469083575543901 no 1556 0.455423268214931 2081 904970
SGTC_1498 4478-3555 97.6 µM 0.111966770725076 0.469085229630234 no 1557 0.455424876987998 2224 3437919
SGTC_2049 5262831 67.185 µM 0.110646653043975 0.469623358693698 no 1558 0.455948275405703 2118 763417
SGTC_1886 st057356 49.9 µM 0.110462711654353 0.46969834447201 no 1559 0.456021210320746 2027 24207747
SGTC_1519 esterone 74 µM 0.110216134854874 0.469798865965761 no 1560 0.456118983233683 1996 698 A steroid.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.1078049776334 0.470781918285622 no 1561 0.457075197162446 2117 2724 A muscle relaxant with antifungal properties.
SGTC_413 propylparaben 100 µM 0.104941524306885 0.471949606977604 no 1562 0.458211104613713 2085 7175 A pharmaceutical preservative.
SGTC_34 0469-0683 81.75 µM 0.104789271151659 0.472011701188706 no 1563 0.45827151177851 2157 3690923
SGTC_927 2425-1185 123 µM 0.103622211484801 0.472487691798751 no 1564 0.458734580167598 2209 730375
SGTC_1274 0865-0114 173 µM 0.102676030279628 0.472873624993814 no 1565 0.459110049072842 2143 870624
SGTC_810 3825-7150 143 µM 0.1025353106584 0.472931024611668 no 1566 0.459165893342223 2231 22330411 YGL099W LSG1
SGTC_3171 9103192 49.47 µM 0.102457208363162 0.472962882827353 no 1567 0.45919688841254 2234 13018434
SGTC_771 0250-0039 27.3 µM 0.10184881418949 0.473211054970677 no 1568 0.459438339475941 2104 3005115
SGTC_2471 5466956 24.79 µM 0.10078691790051 0.473644241565972 no 1569 0.459859805980063 2137 724419
SGTC_911 3456-4043 236 µM 0.100708168862455 0.473676367445789 no 1570 0.459891063265883 2180 914281
SGTC_1222 0366-0074 1.18 µM 0.100576662364279 0.473730016253535 no 1571 0.459943261741115 2232 286520
SGTC_961 1252-1571 372 µM 0.100339481952173 0.473826776526443 no 1572 0.460037406787195 2223 6813498
SGTC_1841 st054148 70 µM 0.0997351137524671 0.474073341931578 no 1573 0.460277311385107 2102 675442
SGTC_2772 vinpocetine 57.06 µM 0.0996413453000139 0.474111597742872 no 1574 0.460314534169837 2194 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1443 4112-3303 14 µM 0.0990917557420383 0.474335825005812 no 1575 0.460532708918285 2196 704433
SGTC_342 k048-0088 23.3 µM 0.098421720557759 0.47460920391893 no 1576 0.460798713950435 2190 6820570
SGTC_2635 hydroquinidine 100 µM 0.0976224015673067 0.474935347132332 no 1577 0.461116067795361 2171 442912 An experimental heart treatment.
SGTC_724 3910-0327 137 µM 0.0964790863062347 0.475401879030706 no 1578 0.461570041571298 2142 2885483
SGTC_3062 9077494 49.47 µM 0.0957839662942726 0.475685540559156 no 1579 0.461846075923207 2186 16459633
SGTC_1875 nocodazole 6 µM 0.095766824118018 0.475692536019617 no 1580 0.461852883368288 2264 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3181 9108277 49.47 µM 0.0943318632628539 0.476278147994882 no 1581 0.462422769767933 2196 17097298
SGTC_3318 9139014 38.6185 µM 0.0939900403332267 0.47641765459661 no 1582 0.462558534187261 2155 16643984
SGTC_2281 7943571 200 µM 0.0937528425159572 0.47651446273792 no 1583 0.462652746417489 2274 1244024
SGTC_2728 chlorpromazine 9.18 µM 0.0922226489488107 0.477139017550547 no 1584 0.463260571732902 2257 2726 A thorazine and dopamine antagonist.
SGTC_3002 9075603 71.4286 µM 0.0918168836358099 0.477304641818802 no 1585 0.463421764762265 2258 20105405
SGTC_1012 4112-3522 18 µM 0.0917018381094139 0.477351601527918 no 1586 0.463467468473709 2234 3112398
SGTC_3349 9149703 23.001 µM 0.0902421115372187 0.477947465217333 no 1587 0.464047410327534 2237 4910494
SGTC_1060 3448-7350 82 µM 0.0900632758947365 0.478020469747935 no 1588 0.464118466085834 2241 570178
SGTC_1793 st048256 72.231 µM 0.0899884830881388 0.478051001988621 no 1589 0.464148183429849 2253 672022
SGTC_2280 7785178 200 µM 0.0897570372649786 0.47814548461175 no 1590 0.464240144811935 2179 2954328
SGTC_2200 6600604 21.907 µM 0.0882063247749612 0.478778560011159 no 1591 0.464856345235096 2238 2904777
SGTC_3210 9128157 49.47 µM 0.0880954458472534 0.478823828190784 no 1592 0.464900407997757 2000 17590849
SGTC_1676 st018489 23.4 µM 0.0867663004686078 0.4793664951547 no 1593 0.465428637449597 2085 3696235
SGTC_3267 9137951 49.47 µM 0.0861880231880187 0.479602607720513 no 1594 0.465658475695093 2118 16643986
SGTC_2229 7354935 190 µM 0.0855161532936312 0.479876943449804 no 1595 0.465925527020478 2247 318112
SGTC_130 0136-0219 337.655 µM 0.0843239682546317 0.480363755947124 no 1596 0.46639942817694 2281 234244
SGTC_3157 9099274 49.47 µM 0.0842136793073619 0.480408792425342 no 1597 0.466443271154719 2261 17217662
SGTC_2023 5144124 124 µM 0.0836219076682368 0.480650446558784 no 1598 0.46667852406985 2205 2830192
SGTC_2427 5545055 42.75 µM 0.0833522300293316 0.480760573693629 no 1599 0.466785735592918 2197 5372858
SGTC_3050 9093513 49.47 µM 0.0831703549547369 0.480834846090377 no 1600 0.466858042184297 2239 25236664
SGTC_1687 st020778 55.3625 µM 0.0826792415630764 0.481035405578489 no 1601 0.467053295591125 2171 4259299
SGTC_1631 benzylvanillin 81.9 µM 0.0825628166341385 0.481082951565145 no 1602 0.467099584159512 2173 75506
SGTC_2485 5633444 17.78 µM 0.0825021675638763 0.481107719734024 no 1603 0.467123697372963 2151 5724239
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.081634151054681 0.481462212576871 no 1604 0.467468821651054 2216 7104
SGTC_1895 st058434 18.3 µM 0.0815808485427183 0.481483981490177 no 1605 0.46749001558558 2273 5393175
SGTC_132 0417-1715 25.805 µM 0.080898142926595 0.48176280546781 no 1606 0.467761478428197 2279 6769098
SGTC_2089 5281248 129.67 µM 0.0806562788304921 0.48186158739311 no 1607 0.467857653958978 2220 2737878
SGTC_331 k048-0133 24.5 µM 0.0805253129360285 0.4819150768358 no 1608 0.467909732395127 2263 6813582
SGTC_2302 7771753 200 µM 0.0781287141472563 0.482893958665235 no 1609 0.468862833206552 2178 2203047
SGTC_2141 5621638 7.665 µM 0.0777618019636599 0.483043831826642 no 1610 0.469008766010271 2258 2856238
SGTC_3228 9131799 49.47 µM 0.0776414864235042 0.483092977815674 no 1611 0.469056620286746 2182 17015818
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0766714463276858 0.483489225060874 no 1612 0.469442460093227 2241 688667
SGTC_1033 k072-0102 21.3 µM 0.0765744905947071 0.483528830967992 no 1613 0.469481026455007 2276 5965931
SGTC_1807 st050092 58.9 µM 0.076406051571124 0.483597637809662 no 1614 0.469548027612234 2205 5008496
SGTC_1812 st052057 4.327 µM 0.0748568216677542 0.484230516276772 no 1615 0.470164315719118 2253 3645418
SGTC_569 4130-2812 160 µM 0.0740495195940461 0.484560324427152 no 1616 0.470485491223896 2314 743552
SGTC_2275 7947463 200 µM 0.0734942075408393 0.484787192917176 no 1617 0.470706426662065 2279 1225414
SGTC_206 4546-0025 72.014 µM 0.0733737091561168 0.48483642226295 no 1618 0.470754369122031 2180 6620745 YIL048W NEO1
SGTC_3083 9117465 49.47 µM 0.0729457641881131 0.485011260086053 no 1619 0.470924638182334 2121 16420915
SGTC_2770 toltrazuril 17.5 µM 0.0729305373768803 0.485017481085322 no 1620 0.470930696664196 2281 68591 Kills coccidiodes.
SGTC_1208 2323-2347 50.3 µM 0.0720508533941725 0.485376887060551 no 1621 0.471280718911672 2286 5412760
SGTC_2244 6635614 200 µM 0.0711575910279412 0.485741852809766 no 1622 0.47163616663677 2129 836499
SGTC_1330 1469-0054 61.8 µM 0.070955443321445 0.485824447221071 no 1623 0.471716608570278 2288 7102664
SGTC_2348 9022543 33.42 µM 0.0694821420270007 0.486426433376623 no 1624 0.472302923447079 2229 3162678 YDL140C RPO21
SGTC_2395 5646831 180.19 µM 0.0690366503672969 0.486608465984828 no 1625 0.472480223152591 2247 6808628
SGTC_2055 5235184 200 µM 0.0688255397219459 0.486694729006109 no 1626 0.472564244264423 2235 2836034
SGTC_2337 9009472 200 µM 0.0681738205583958 0.486961035280606 no 1627 0.47282363332124 2263 5742383
SGTC_707 0865-0008 204 µM 0.0677782483127926 0.487122677334236 no 1628 0.47298107963407 2234 723043
SGTC_3266 9136860 49.47 µM 0.0676960799750672 0.487156253916814 no 1629 0.473013784940695 2279 4871271 YPR165W RHO1
SGTC_1958 st076513 41.9 µM 0.0667201313799059 0.487555064288134 no 1630 0.473402253748848 2256 732122 YGL099W LSG1
SGTC_116 0155-0182 31.788 µM 0.0666946294559783 0.487565485529917 no 1631 0.473412404933639 2133 771486
SGTC_497 capsazepine 133 µM 0.066485515509355 0.4876509392845 no 1632 0.473495644571307 2267 2733484 A calcium channel blocker.
SGTC_3319 9138450 16.7555 µM 0.0653089420353257 0.488131752779394 no 1633 0.473964011415777 2163 2029690
SGTC_79 0052-0007 94.094 µM 0.0648193515292836 0.488331831868793 no 1634 0.474158916779205 2289 2801472
SGTC_1550 gossypolone 36.6 µM 0.0638764416300044 0.488717175500029 no 1635 0.474534305408897 2287 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2923 7992654 58.14 µM 0.0635253717893086 0.488860651650484 no 1636 0.474674078137855 2244 2985126
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0616760483795065 0.489616461391144 no 1637 0.475410407135963 2222 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_151 3013-0144 2.285 µM 0.0611096459174813 0.489847954986041 no 1638 0.475635943589375 2301 906558 YHR107C CDC12
SGTC_855 0428-0020 25 µM 0.0594086226523313 0.490543198180769 no 1639 0.476313322654173 2190 6812414
SGTC_1431 4049-0260 9.09 µM 0.0593713757978695 0.490558422065441 no 1640 0.476328155816591 2282 3854841
SGTC_316 k060-0003 58.6 µM 0.0592096448905171 0.490624526402252 no 1641 0.476392563805178 2272 6152314
SGTC_518 1021-0119 62.6 µM 0.0589545760586963 0.490728781307924 no 1642 0.47649414409857 2124 1097762
SGTC_173 1273-0061 2.693 µM 0.0585382960125343 0.490898929823533 no 1643 0.47665992948671 2222 2847414 YPL266W DIM1
SGTC_1478 0453-0656 35.7 µM 0.0576377955596238 0.491267002130502 no 1644 0.477018571599219 2299 5258496
SGTC_2638 epoxomicin 18 µM 0.0552485539060346 0.492243620614903 no 1645 0.477970223776978 2308 9915668 A protesome inhibitor.
SGTC_205 1486-1330 71.903 µM 0.0541060628674517 0.492710638250524 no 1646 0.478425330927824 2294 4118834
SGTC_1618 st003135 44.5 µM 0.0524219932250413 0.493399055752658 no 1647 0.47909622507448 2309 1270615
SGTC_3208 9114115 49.47 µM 0.0513952883490709 0.49381876409141 no 1648 0.47950526958302 2188 650895
SGTC_1960 st011366 51.8 µM 0.0508517287234998 0.494040969505413 no 1649 0.479721835302414 2316 3972846
SGTC_3337 9144342 33.5465 µM 0.0506883750860522 0.494107748307668 no 1650 0.479786920039751 2303 17682949
SGTC_1658 st012944 20 µM 0.0506523789325656 0.49412246352118 no 1651 0.479801262004081 2292 24207260
SGTC_595 3909-8003 73.7 µM 0.0505293354264715 0.494172763718774 no 1652 0.47985028648332 2263 699517
SGTC_836 0330-0104 1.35 µM 0.0503802398148441 0.494233714143792 no 1653 0.479909691365347 2329 46494820
SGTC_137 0438-0332 85.389 µM 0.049201114502938 0.494715746297046 no 1654 0.480379511549568 2305 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1006 4099-6547 255 µM 0.0490616446213326 0.494772762785869 no 1655 0.480435084867637 2285 3146833
SGTC_2595 hexamethylquercetagetin 100 µM 0.0478335792621471 0.495274810960654 no 1656 0.480924437397614 2278 386331
SGTC_1005 4092-0690 4.4 µM 0.0471685788572965 0.495546674453281 no 1657 0.481189435037965 2271 1529343
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0471524108478339 0.495553284237208 no 1658 0.48119587797164 2281 688761
SGTC_1030 k029-0042 36.7 µM 0.047131811345136 0.49556170570002 no 1659 0.481204086857525 2190 6080581
SGTC_977 1348-1378 135 µM 0.0467723655299577 0.495708654201637 no 1660 0.48134732701653 2325 X977
SGTC_1716 st033144 30.6155 µM 0.0465870408411334 0.495784418799284 no 1661 0.481421180363525 2314 674617
SGTC_1090 efavirenz 20.7 µM 0.0462964298810047 0.495903226925464 no 1662 0.481536992401178 2248 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2816 7982706 58.44 µM 0.0458149368802173 0.496100072605715 no 1663 0.481728876701718 2274 2981853
SGTC_2301 7769476 200 µM 0.0452938125269887 0.496313121584877 no 1664 0.481936559633465 2272 977820
SGTC_827 3253-0474 693 µM 0.0450625829649232 0.496407654490972 no 1665 0.482028712788542 2317 5402065
SGTC_271 rotenone 740 µM 0.0443997601926194 0.496678635487456 no 1666 0.482292876400213 2268 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_543 3844-1095 191 µM 0.044029997122608 0.496829805930077 no 1667 0.482440246400411 2287 4230703
SGTC_1358 1509-0022 2.48 µM 0.0434418476753673 0.497070260326478 no 1668 0.482674659774914 2295 3258434
SGTC_2285 7945142 200 µM 0.0431456985640371 0.497191336009413 no 1669 0.482792695504263 2297 2970608
SGTC_1710 st031758 61.5 µM 0.0423406823578531 0.497520454891895 no 1670 0.48311355725869 2316 5394341
SGTC_2827 7993847 71.43 µM 0.0415373305301344 0.497848895000568 no 1671 0.483433766531454 2291 2985692
SGTC_571 k831-0106 44.2 µM 0.0401805288957014 0.49840360917101 no 1672 0.483974600391505 2346 4783639
SGTC_1250 0485-0349 40.2 µM 0.0397847065731866 0.498565437620718 no 1673 0.484132384482446 2306 6842794 YDL195W SEC31
SGTC_3282 9108498 15.4605 µM 0.0397660828935111 0.498573051753177 no 1674 0.484139808380754 2281 16459645
SGTC_1932 st074806 40.9 µM 0.0396269266562469 0.498629944609171 no 1675 0.484195279963706 2284 17251235
SGTC_1059 3448-6867 171 µM 0.0388173800389684 0.498960921443461 no 1676 0.484517994005017 2354 3934407
SGTC_1497 4476-2978 41.3 µM 0.0374086463191966 0.499536872832645 no 1677 0.485079589365889 2302 1528379
SGTC_1940 st075990 51.1 µM 0.0363237626009802 0.499980421028455 no 1678 0.485512101312143 2275 1084979
SGTC_1876 myriocin 605 nM 0.0362279853994208 0.499980421028455 no 1679 0.485550285754862 2342 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1971 st069429 63.5 µM 0.0356189314464317 0.499731412937717 no 1680 0.485793106394051 2346 1246522 YGL099W LSG1
SGTC_1253 0550-0034 176 µM 0.0355412256746629 0.49969964340002 no 1681 0.485824086895866 2294 5969915
SGTC_1649 st011737 51.3 µM 0.0354597517881142 0.499666333293294 no 1682 0.485856569798647 2290 1761035
SGTC_1131 3454-3128 32.3 µM 0.0339447434726634 0.499046931960288 no 1683 0.48646060679902 2274 710982
SGTC_405 ebelactone b 50 µM 0.0331208664342055 0.498710096040669 no 1684 0.486789101434566 2296 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1084 voriconazole 435 nM 0.032712936505502 0.498543317288304 no 1685 0.486951753786833 2347 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_638 3970-0837 4.09 µM 0.03165157920295 0.498109391464481 no 1686 0.487374954858633 2331 4118451 YLR208W SEC13
SGTC_631 k072-0230 41.5 µM 0.0315214654881949 0.498056195855104 no 1687 0.487426836832675 2325 5773147
SGTC_3078 9116413 49.47 µM 0.0310430076686999 0.497860583765316 no 1688 0.487617620513213 2341 17177322
SGTC_1176 0848-0131 83.3 µM 0.0305936525170351 0.497676870440957 no 1689 0.487796802169781 2335 6769040
SGTC_474 dl-dihydrosphingosine 5 µM 0.030449065007764 0.497617757719858 no 1690 0.48785445737969 2334 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2215 7188065 200 µM 0.0303865669609105 0.497592206223041 no 1691 0.487879378961085 2349 940217
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0302176753146177 0.497523157165139 no 1692 0.487946726052745 2315 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1117 retinoic acid 1.10837 µM 0.0288258349129586 0.49695412511824 no 1693 0.488501748078762 2338 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2805 7950783 58.44 µM 0.0281996604686022 0.496698125501708 no 1694 0.488751454012249 2335 1178958 YDL195W SEC31
SGTC_1567 st069303 68.4 µM 0.0271383026754795 0.496264212538652 no 1695 0.489174712442172 2302 5581319
SGTC_533 1222-0222 6.71 µM 0.0267557675415421 0.496107822457025 no 1696 0.489327266481851 2347 3982874
SGTC_1513 0337-0559 19 µM 0.0264007498238118 0.495962682728913 no 1697 0.489468848043291 2333 775073
SGTC_70 0141-0289 43.283 µM 0.0262632942278925 0.495906487738501 no 1698 0.489523665884173 2255 352408
SGTC_2310 7668677 200 µM 0.0252527958845562 0.495493375477544 no 1699 0.489926662668762 2343 2197143
SGTC_2162 5663267 200 µM 0.0250224172983945 0.495399192689662 no 1700 0.490018541393442 2354 6456493
SGTC_505 gw-5074 63.9 µM 0.0241333631203966 0.495035734272237 no 1701 0.490373115572475 2348 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_876 0720-0963 56.8 µM 0.0236592253290777 0.494841901438783 no 1702 0.490562215183642 2359 765861
SGTC_757 1066-0008 322 µM 0.0234304401971398 0.494748371950093 no 1703 0.490653461950455 2352 6842497
SGTC_2789 5281112 71.43 µM 0.0233140142106278 0.494700776035038 no 1704 0.490699896514558 2356 765948
SGTC_215 1287-0124 461.5 µM 0.0228290896577826 0.494502535649455 no 1705 0.490893301938231 2358 5560863
SGTC_728 3030-5151 22.5 µM 0.020970149661411 0.493742601608985 no 1706 0.491634733778578 2366 3125388
SGTC_1055 3448-0672 86 µM 0.0196238831370553 0.493192262329702 no 1707 0.492171705756026 2346 748378
SGTC_2045 5106652 78.05 µM 0.019510440016198 0.493145888579032 no 1708 0.492216954350253 2361 673349
SGTC_3242 9133940 49.47 µM 0.0192672067464003 0.493046458984608 no 1709 0.492313972147843 2364 17248444
SGTC_1292 0kpi-0043 232 µM 0.0191535312969533 0.492999990555744 no 1710 0.492359313723686 2354 3333905
SGTC_717 1532-0246 73.2 µM 0.019121309134974 0.492986818746985 no 1711 0.492372166152707 2355 9561992
SGTC_3146 9095609 49.47 µM 0.0185051567260163 0.492734948814676 no 1712 0.492617931899191 2368 17173999
SGTC_2409 alverine citrate 63.97 µM 0.0185040309679414 0.492734488631463 no 1713 0.492618380934798 2331 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1245 0418-0076 17.2 µM 0.0182227927147778 0.492619525405183 no 1714 0.492730559848687 2345 6790114
SGTC_2537 larixol 68.93 µM 0.0171545786426454 0.492182871639785 no 1715 0.49315664892169 2371 6708759
SGTC_451 chloral hydrate 100 µM 0.0163958629947181 0.491872737174627 no 1716 0.49345929007937 2365 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2401 5128683 200 µM 0.0162141248460257 0.491798450166466 no 1717 0.493531783473818 2366 708373
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0150236550385655 0.491311842698148 no 1718 0.494006654259687 2384 4000243
SGTC_3128 9127691 49.47 µM 0.0144838546295535 0.491091202167497 no 1719 0.494221980026597 2359 41316314
SGTC_2405 ticlatone 3.52 µM 0.0121318733450338 0.49012987508933 no 1720 0.495160201504635 2388 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_662 k832-1615 104 µM 0.0114836598752211 0.489864940151523 no 1721 0.495418783233149 2370 5878478
SGTC_282 k297-0036 65.7 µM 0.0111909141409841 0.489745291870633 no 1722 0.495535564378106 2367 5061378
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0106872098632879 0.489539424765524 no 1723 0.49573650128645 2382 6708739 YPR165W RHO1
SGTC_2166 5933061 31.504 µM 0.0105840353176776 0.489497257022148 no 1724 0.495777659647027 2378 2877375
SGTC_485 niflumic acid 177 µM 0.010366263830524 0.489408253554199 no 1725 0.495864533134156 2385 4488 A COX2 inhibitor.
SGTC_1835 st008666 49.2 µM 0.0101135662962657 0.489304976430305 no 1726 0.495965339579245 2379 690455
SGTC_2626 ethyl orsellinate 100 µM 0.0100257318644956 0.489269078790193 no 1727 0.496000378671253 2385 75653 A natural product.
SGTC_2003 4023581 200 µM 0.00908349624865858 0.48888399575526 no 1728 0.496376259125029 2377 16641307
SGTC_1413 3910-0535 34.4 µM 0.00903423622026944 0.488863863916378 no 1729 0.496395910226754 2383 2876951
SGTC_950 1165-0508 94.1 µM 0.00867816772696444 0.488718344880918 no 1730 0.496537955432126 2370 6148369
SGTC_3194 9111903 49.47 µM 0.00840417298023849 0.488606368987777 no 1731 0.496647259533834 2381 17087251
SGTC_604 1000-0114 314 µM 0.0070531034022446 0.488054228554913 no 1732 0.497186242173812 2392 1572745
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.00679914304743559 0.487950445321195 no 1733 0.497287555266536 2394 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_378 3970-0959 8.33 µM 0.0059254071210424 0.487593391378735 no 1734 0.497636118403657 2389 6615653
SGTC_623 k072-0108 16.9 µM 0.00576718052984618 0.487528732819332 no 1735 0.497699240601962 2381 5382803
SGTC_165 k038-0023 64.381 µM 0.00508551170017424 0.487250175797306 no 1736 0.49797118311035 2396 46368543
SGTC_2426 5582046 32.21 µM 0.00504406521364864 0.487233239312089 no 1737 0.497987717654124 2392 2251934
SGTC_1501 4491-0275 38.4 µM 0.00504332447507485 0.487232936620588 no 1738 0.497988013162301 2398 5104718
SGTC_1122 capsaicin 818.572 nM 0.00491175972716852 0.487179174813213 no 1739 0.498040499252614 2387 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1931 st074438 57.1 µM 0.00396160267676747 0.486790915472185 no 1740 0.498419553328087 2398 2787313
SGTC_3265 9137266 49.47 µM 0.00393426415966472 0.486779744413419 no 1741 0.498430459733447 2395 17224265
SGTC_1991 st073000 8.92 µM 0.00386408749222279 0.486751068886718 no 1742 0.49845845596036 2392 4301969 YIL048W NEO1
SGTC_3271 9137798 49.47 µM 0.00309049740184043 0.486434969772536 no 1743 0.498767071881587 2400 6498326
SGTC_2790 5423970 71.43 µM 0.00308690273062367 0.486433500962204 no 1744 0.498768505941079 2396 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_121 0557-0495 61.343 µM 0.00232082493683634 0.486120479909358 no 1745 0.499074125638448 2399 3104427
SGTC_726 3448-4391 34.2 µM 0.000436622773993337 0.485350627587867 no 1746 0.499825812720402 2402 1356692
SGTC_3017 9080681 49.47 µM 0.000130653520288827 0.485225618935243 no 1747 0.499947876786822 2404 16451914
SGTC_2386 9075165 157.42 µM 9.21061166105577e-05 0.485209869877113 no 1748 0.499963254975852 2405 16452277
SGTC_1673 st016611 27.3 µM 5.55571335462204e-05 0.485194937321801 no 1749 0.499977835910462 2405 5226799
SGTC_62 0180-0423 3.232 µM 0 0.485172238782841 no 1750 0.5 2406 30102 YGL099W LSG1
SGTC_1739 st037196 92.5 µM 0 0.485172238782841 no 1751 0.5 2406 612214
SGTC_2906 7926292 26.41 µM 0 0.485172238782841 no 1752 0.5 2405 2966319
SGTC_2167 5876490 200 µM -0.00156677125359425 0.484532135491666 no 1753 0.49937494895895 2413 686534
SGTC_2859 9028643 45.46 µM -0.00249538067334972 0.484152771474798 no 1754 0.499004488176867 2414 17151580
SGTC_1910 st062352 60.4 µM -0.00279925413462923 0.484028633406311 no 1755 0.498883260630537 2412 2245730
SGTC_2438 5259590 200 µM -0.00372639504524517 0.483649888389457 no 1756 0.498513386903497 2416 1201127
SGTC_1693 xanthone 101.9 µM -0.00472835403083604 0.483240596143575 no 1757 0.498113666689292 2426 7020 An insecticide.
SGTC_1499 4480-0877 67.3 µM -0.00546655858507505 0.482939056751746 no 1758 0.497819169513849 2421 2861909
SGTC_1380 2291-0730 164 µM -0.00657221792916149 0.482487438931511 no 1759 0.497378083267258 2426 2999191
SGTC_1817 st052116 64.4 µM -0.00659206661063768 0.482479331738985 no 1760 0.497370164960538 2417 4361398
SGTC_1834 st055981 52.8 µM -0.00674207791441114 0.482418059867239 no 1761 0.497310320439036 2422 471719 YDL150W RPC53
SGTC_568 1193-0097 7.48 µM -0.00739918425425764 0.482149670769879 no 1762 0.497048179494863 2419 3646150
SGTC_2870 9038528 12.99 µM -0.00887764502402986 0.481545836700664 no 1763 0.496458378570301 2468 6463316
SGTC_2249 haloperidol 116.36 µM -0.00892716252376586 0.481525613450842 no 1764 0.496438624728828 2416 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1279 0874-0590 65.2 µM -0.00937225715515026 0.481343836220902 no 1765 0.496261065095607 2438 3523074
SGTC_893 0958-0369 48.9 µM -0.0107475556502743 0.480782187191205 no 1766 0.495712428183167 2435 6819948
SGTC_2890 9046729 58.44 µM -0.0113753739448474 0.480525809256907 no 1767 0.495461980247538 2435 903329
SGTC_558 k064-0027 21.3 µM -0.0119243025829564 0.480301653557904 no 1768 0.495243004267697 2438 5088526
SGTC_152 4469-0003 551.229 µM -0.0141709712690328 0.479384289254212 no 1769 0.494346789616647 2432 697280
SGTC_2580 diallyl disulphide 81.36 µM -0.0150386906493425 0.47903000928549 no 1770 0.494000656596419 2446 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1415 3966-0071 78.1 µM -0.0175120119108548 0.478020272161053 no 1771 0.49301407509861 2449 2893185
SGTC_2047 4141938 200 µM -0.0176220315226814 0.477975359718394 no 1772 0.492970190395738 2451 3807862
SGTC_767 0929-0023 86 µM -0.0176625356190592 0.477958825119434 no 1773 0.492954034113683 2436 1204563
SGTC_2088 5278280 127.392 µM -0.0178700151781288 0.477874128323628 no 1774 0.492871274807527 2460 791502
SGTC_13 0199-0087 65 µM -0.0205701913230659 0.476771961574943 no 1775 0.491794259655638 2450 4589825
SGTC_616 4092-0450 108 µM -0.0217668338647904 0.476283568415729 no 1776 0.491316975328636 2460 787165
SGTC_2814 7977482 42.97 µM -0.0218727139536408 0.476240356621722 no 1777 0.49127474533866 2461 6456762
SGTC_2161 5662504 8.5105 µM -0.0222157649133286 0.476100352546544 no 1778 0.491137921055995 2469 2859334
SGTC_3329 9141233 27.5565 µM -0.0229162479622478 0.475814484430178 no 1779 0.490858539899729 2466 4909101 YNL103W MET4
SGTC_1049 3226-0134 66 µM -0.0232909212122186 0.475661584851047 no 1780 0.490709106787053 2434 5702385
SGTC_425 3825-7017 13.1 µM -0.0233940155696422 0.475619513930191 no 1781 0.490667989292411 2577 3397440
SGTC_2711 st079103 59.1 µM -0.023892432742032 0.475416122844122 no 1782 0.490469205179253 2476 54693780
SGTC_3258 9138477 49.47 µM -0.0239176049621547 0.475405850885215 no 1783 0.49045916578527 2452 4970355
SGTC_112 phenothiazine 287.218 µM -0.0239995440710869 0.475372414330746 no 1784 0.490426486190914 2448 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_283 0987-0079 11.7 µM -0.0242539512837047 0.475268600534308 no 1785 0.490325021933103 2431 411556
SGTC_2442 5158906 48.48 µM -0.0259607120044059 0.474572180904508 no 1786 0.48964433757975 2481 1893835
SGTC_2679 rapamycin 1 nM -0.0261866920897177 0.47447997869736 no 1787 0.489554215208893 2459 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1776 st049249 45.9 µM -0.0263309714152016 0.474421111958075 no 1788 0.489496675926662 2469 1822314
SGTC_865 0488-0499 301 µM -0.0271687357163672 0.474079310702472 no 1789 0.489162575890488 2444 9634651
SGTC_163 TUB2.036 7.546 µM -0.0279176470285498 0.473773776912771 no 1790 0.488863916817729 2450 15992207 YJR013W GPI14
SGTC_1845 st056753 3.01 µM -0.0282945435066077 0.473620020058387 no 1791 0.488713616255072 2446 5375839
SGTC_2219 9098279 200 µM -0.0284715589601212 0.47354780704969 no 1792 0.488643025745973 2459 902349
SGTC_3028 9087778 49.47 µM -0.0286595589094392 0.47347111389546 no 1793 0.488568055211474 2468 17217395
SGTC_2597 laccaic acid a 100 µM -0.028892482169599 0.473376095981243 no 1794 0.488475170740007 2474 5491415 A textile dye.
SGTC_3137 9097352 49.47 µM -0.0299554121415431 0.472942507291712 no 1795 0.488051306576913 2483 44120435
SGTC_2437 5741531 144.16 µM -0.0304269679929216 0.47275016122018 no 1796 0.487863268730497 2472 2262990
SGTC_2945 9067681 61.76 µM -0.0305820864535258 0.472686890300016 no 1797 0.487801414203478 2446 16456930
SGTC_2036 5160441 105 µM -0.031402682095695 0.472352190892135 no 1798 0.487474201102276 2470 134534 YIL048W NEO1
SGTC_948 3448-0295 75.3 µM -0.0317353959662502 0.472216491192615 no 1799 0.487341533597618 2480 678569
SGTC_909 3448-9333 149 µM -0.0326304008438104 0.471851473188268 no 1800 0.486984663182856 2472 3344074
SGTC_417 st075190 100 µM -0.0338296086913605 0.471362426426433 no 1801 0.486506512565903 2453 222757
SGTC_1315 1237-0019 3.69 µM -0.0341297975237882 0.471240013695445 no 1802 0.486386823666553 2465 825140
SGTC_325 2810-4341 181 µM -0.034192747415207 0.471214343970427 no 1803 0.486361724942609 2469 774970
SGTC_2757 clomiphene 4.22 µM -0.0355098960196711 0.4706772643219 no 1804 0.485836577735256 2483 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1401 3807-4679 7.6 µM -0.0355909710726426 0.470644206944093 no 1805 0.485804253901174 2467 3291456
SGTC_3354 9151612 71.43 µM -0.0357661041862026 0.470572799214017 no 1806 0.485734430352935 2481 27261949
SGTC_1863 st057641 20.1 µM -0.0357736628242595 0.470569717321349 no 1807 0.485731416821132 2456 3921635
SGTC_745 0469-0705 296 µM -0.0358904761822956 0.470522089093351 no 1808 0.485684844941006 2483 3486736
SGTC_2820 7989630 71.43 µM -0.0360069336339186 0.47047460639858 no 1809 0.485638415150234 2477 2984098
SGTC_338 4055-0136 114 µM -0.0364061074714992 0.470311856159943 no 1810 0.48547927217567 2461 2900563
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0371069710521559 0.470026113687264 no 1811 0.485199856881098 2465 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2396 5342950 42.78 µM -0.0374327621453367 0.469893293722752 no 1812 0.48506997527692 2489 1886677
SGTC_2129 girgensonine 121.053 µM -0.0383623685757771 0.46951432609656 no 1813 0.4846993822042 2517 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2261 9010538 184.68 µM -0.0384783949479477 0.469467028184314 no 1814 0.484653128529446 2551 6457250
SGTC_2097 5376186 200 µM -0.0388239224666368 0.469326177155835 no 1815 0.484515385919993 2475 742755
SGTC_761 k216-0224 480 µM -0.038825848173515 0.46932539217036 no 1816 0.484514618252897 2475 1340404
SGTC_1459 k035-0031 35.7 µM -0.0389845298022111 0.46926070839862 no 1817 0.484451361333545 2457 3877128 YMR208W ERG12
SGTC_3224 9130643 49.47 µM -0.0392860097936602 0.469137817625166 no 1818 0.484331180286766 2534 17644395
SGTC_3027 9089541 49.47 µM -0.0406396297905771 0.468586084713649 no 1819 0.483791595117666 2522 9943819
SGTC_2851 9015922 71.43 µM -0.042243282458489 0.467932517120516 no 1820 0.483152379462184 2506 2996893
SGTC_1152 3909-8331 15.9 µM -0.0427927539658953 0.46770860015918 no 1821 0.482933370098829 2492 16001939
SGTC_1792 st045773 43.6 µM -0.0428212997184927 0.467696967663176 no 1822 0.482921992420435 2488 2919270
SGTC_3080 9117754 49.47 µM -0.0430784872030102 0.467592164090909 no 1823 0.482819484051023 2479 9550191
SGTC_1887 st057648 70.8 µM -0.0431422986613795 0.467566161350468 no 1824 0.482794050607398 2477 688672
SGTC_960 1222-0186 7.7 µM -0.0442543058869407 0.46711304819681 no 1825 0.482350847291486 2529 3126296
SGTC_703 3875-0075 71.8 µM -0.0449525249155373 0.466828564389411 no 1826 0.482072575149661 2493 2850814
SGTC_2362 9071156 126 µM -0.0453042561339507 0.466685260702183 no 1827 0.481932397509624 2525 653133
SGTC_536 3852-0578 10.6 µM -0.0456405638750707 0.466548244945885 no 1828 0.481798368773046 2485 2869208
SGTC_2905 7799065 20.05 µM -0.0460258382616058 0.466391284471483 no 1829 0.481644827886686 2505 1296806
SGTC_3221 9128209 49.47 µM -0.0461938556929298 0.466322835940815 no 1830 0.481577869847759 2515 16460723
SGTC_433 pimozide 108 µM -0.0469377824192034 0.466019780030155 no 1831 0.481281407624971 2477 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2788 5282734 71.43 µM -0.0476194951613976 0.46574208573346 no 1832 0.481009747380959 2531 743706
SGTC_3102 9121669 49.47 µM -0.048462038353471 0.465398900541828 no 1833 0.480674008940057 2519 41905072
SGTC_746 1095-0025 46.6 µM -0.0489632080638769 0.465194775987984 no 1834 0.480474308232488 2500 6749286
SGTC_1236 0330-0013 258 µM -0.0489991112633911 0.465180153099631 no 1835 0.480460002099806 2525 4617066
SGTC_1205 4161-2785 76 µM -0.0495121385673179 0.464971209152011 no 1836 0.480255581943538 2627 3498106
SGTC_2317 5986382 200 µM -0.0496794865793418 0.464903054331203 no 1837 0.480188901804586 2511 877883
SGTC_2308 7584454 197.62 µM -0.0508794772999795 0.464414371592258 no 1838 0.479710779533639 2510 893577
SGTC_590 k048-0076 22.4 µM -0.0516172867233772 0.464113933593582 no 1839 0.479416822443959 2525 6832814
SGTC_361 000s-0510 1.45 µM -0.0519576463943658 0.463975345098644 no 1840 0.479281220541484 2541 660
SGTC_500 h-89 112 µM -0.0530144491872338 0.463545061447516 no 1841 0.47886019755844 2517 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_935 2996-0153 430 µM -0.0532641213737176 0.463443412114604 no 1842 0.478760733299228 2497 23738523
SGTC_1972 st070201 17.4 µM -0.0532904219255379 0.46343270447863 no 1843 0.478750255777719 2524 2829099
SGTC_2328 6201408 200 µM -0.0536352933024908 0.463292300861056 no 1844 0.478612868490673 2543 2890418
SGTC_1725 st036284 20.55 µM -0.0540373875402446 0.463128606516131 no 1845 0.478452688396995 2501 707914
SGTC_2646 retinol 96.75 µM -0.0543932749145327 0.462983728397252 no 1846 0.478310918382708 2560 445354 A vitamin A analog and teratogen.
SGTC_863 0466-0191 129 µM -0.0544926299965006 0.462943282832983 no 1847 0.478271340138892 2501 765160 YPR165W RHO1
SGTC_2534 helenine 20.12 µM -0.0553479629308051 0.46259510895072 no 1848 0.477930625903384 2513 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1052 3253-3998 198 µM -0.0553649388964382 0.462588198962442 no 1849 0.477923863841501 2498 5450317
SGTC_1642 st009582 77.7 µM -0.0558520589787008 0.462389923804612 no 1850 0.477729831282955 2522 6739311
SGTC_1613 st002381 52.1 µM -0.0565383860035516 0.462110580222978 no 1851 0.47745645840339 2533 551167
SGTC_2346 9031566 143.75 µM -0.0588051349354292 0.461188118924665 no 1852 0.476553659226915 2573 4771086
SGTC_2502 avocadyne acetate 18.59 µM -0.0601533931454939 0.460639539301818 no 1853 0.476016732667915 2499 3952079
SGTC_2688 kanamycin b 96.69 µM -0.0603095758337503 0.46057599647335 no 1854 0.47595453770897 2536 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3154 9100113 49.47 µM -0.0603407969079857 0.460563294319621 no 1855 0.475942104945222 2517 25237525
SGTC_2730 imipramine 71.33 µM -0.0608669401932817 0.460349241352254 no 1856 0.47573258925672 2534 3696 A tricyclic antidepressant.
SGTC_1198 1612-1005 86.7 µM -0.0610042269981197 0.460293390302587 no 1857 0.475677921335016 2606 6998509
SGTC_384 k007-0144 5.16 µM -0.0616812196600095 0.46001798746877 no 1858 0.475408348013966 2571 6824886
SGTC_2690 usnic acid 100 µM -0.0621876969805408 0.459811963370114 no 1859 0.47520667995699 2569 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3183 9108214 49.47 µM -0.0624517387381957 0.459704561128273 no 1860 0.475101546889855 2507 4974831
SGTC_1410 3909-8106 77.9 µM -0.0629934374280538 0.459484227717264 no 1861 0.474885865058842 2552 1039210
SGTC_1050 3232-1156 69.3 µM -0.0633339290106961 0.459345740721539 no 1862 0.474750299271051 2552 700529
SGTC_980 1473-0395 201 µM -0.0649020455186408 0.458708009902769 no 1863 0.474125995970848 2516 768876
SGTC_1882 5615643 20 µM -0.066055967998402 0.458238793713953 no 1864 0.473666633345791 2505 2253075
SGTC_2019 4016004 108 µM -0.0666457671590753 0.457998987803021 no 1865 0.473431854895003 2575 45595336
SGTC_217 ketoconazole 989 nM -0.0669669637250505 0.457868399204109 no 1866 0.473304001633978 2512 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1516 st013856 110 µM -0.0673985228210421 0.457692947773712 no 1867 0.473132222567398 2664 5281404 A mutagen and neurotoxin.
SGTC_1072 oxiconazole 14.9 nM -0.0690455882283137 0.457023405279307 no 1868 0.472476665950062 2519 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_868 0527-0199 213 µM -0.07007971910233 0.456603086758177 no 1869 0.47206510441032 2595 2849450
SGTC_3343 9148379 18.9835 µM -0.0711716065229673 0.456159346012423 no 1870 0.471630589403789 2571 1955036
SGTC_102 gallobenzophenone 83.616 µM -0.0712405273598821 0.456131338558267 no 1871 0.471603163584776 2539 70837
SGTC_2489 cantharidin 73.42 µM -0.0712470907305167 0.456128671403788 no 1872 0.471600551815399 2554 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_738 1315-0003 72.4 µM -0.0722380085227463 0.455726015257469 no 1873 0.471206248871928 2578 6251474
SGTC_2919 7978188 46.38 µM -0.0729275164781131 0.455445862798073 no 1874 0.470931898627777 2536 2980291
SGTC_1617 st002906 78 µM -0.073131526722565 0.455362976085685 no 1875 0.470850727061241 2542 5150859
SGTC_639 0833-0042 114 µM -0.0737914346845706 0.455094877378141 no 1876 0.470588171288259 2561 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1475 4092-1048 11.7 µM -0.0740242951758721 0.455000278762691 no 1877 0.470495526768342 2572 2881759
SGTC_1036 k216-0215 33.5 µM -0.0744374706045803 0.454832434230819 no 1878 0.47033114713053 2534 622330
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.0751247772597495 0.454553247064557 no 1879 0.470057717061486 2519 4174840
SGTC_3170 9103054 49.47 µM -0.0761105810477725 0.454152848198275 no 1880 0.469665561050946 2600 16432970
SGTC_1237 0330-0133 46.1 µM -0.076456423814485 0.454012390034469 no 1881 0.469527990605589 2558 X1237 YHR072W ERG7
SGTC_1054 3429-0080 167 µM -0.0779345491599031 0.453412139571862 no 1882 0.46894005836151 2576 1162877
SGTC_1982 st072467 71.9 µM -0.0789838337269671 0.452986101141618 no 1883 0.468522740852294 2518 3163533
SGTC_2176 5809774 33.9695 µM -0.0810284504648294 0.452156086330343 no 1884 0.467709663345753 2595 2870539
SGTC_24 0417-1663 219 µM -0.0811412015711454 0.452110320921844 no 1885 0.467664829789515 2598 4329390
SGTC_921 1561-0023 372 µM -0.0811414978530979 0.452110200662535 no 1886 0.467664711978585 2531 24050882
SGTC_686 1319-0111 510 µM -0.0818103841936099 0.451838714387424 no 1887 0.467398749182439 2593 4562600
SGTC_2877 9040724 71.43 µM -0.082257091997057 0.451657418035281 no 1888 0.467221137183699 2560 6463895
SGTC_1669 st015249 58.4 µM -0.0830276297907311 0.451344719003576 no 1889 0.466914785030802 2579 722793
SGTC_2701 st077767 14.721 µM -0.0834850773935311 0.45115909225184 no 1890 0.466732921241457 2574 5721188
SGTC_646 4092-0839 27.3 µM -0.0842790167285607 0.450836946567575 no 1891 0.466417297631511 2624 877796
SGTC_933 2914-0560 114 µM -0.0846176921505222 0.450699536808519 no 1892 0.466282666606143 2564 463887
SGTC_1347 1493-0251 600 nM -0.0852488041790473 0.450443493402601 no 1893 0.466031795820078 2608 3986378
SGTC_2697 mebhydrolin 72.4 µM -0.085296979029599 0.450423949615742 no 1894 0.466012646583571 2612 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2010 4012422 159 µM -0.0856637474126717 0.450275161337722 no 1895 0.465866860764054 2625 952393
SGTC_1644 st010134 20.9 µM -0.0863145655949921 0.450011158749907 no 1896 0.465608180009083 2574 3818134
SGTC_2813 7971799 71.43 µM -0.0870917606460883 0.449695920727199 no 1897 0.465299287276635 2638 2234054
SGTC_1464 k208-0027 110 µM -0.0885084791111506 0.449121367471212 no 1898 0.464736272716534 2572 X1464
SGTC_2470 5664817 21.68 µM -0.0893594299740661 0.448776313697266 no 1899 0.464398132314716 2557 2859561
SGTC_51 1013-0126 23.419 µM -0.0898542373608361 0.448575691053021 no 1900 0.464201523639382 2564 1627850
SGTC_3123 9126162 49.47 µM -0.0904924426964484 0.448316946269538 no 1901 0.463947949584888 2576 25239884
SGTC_1826 st055655 41.6 µM -0.0905044754016894 0.448312068113566 no 1902 0.46394316884721 2608 676168
SGTC_1195 1502-0147 41.1 µM -0.090988614114598 0.448115800857215 no 1903 0.463750819073646 2567 817940
SGTC_93 0109-0045 59.227 µM -0.091475464387937 0.447918447155759 no 1904 0.463557400533364 2540 88733
SGTC_3269 9137823 49.47 µM -0.0915522716462852 0.447887313098736 no 1905 0.463526886911025 2563 17682936
SGTC_3234 9132280 49.47 µM -0.0925827554328396 0.447469634468306 no 1906 0.463117522034889 2638 17612295
SGTC_1698 5-fluorocytosine 1.055 µM -0.0926322525936584 0.447449573600152 no 1907 0.463097860017909 2580 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3197 9113331 49.47 µM -0.0928567520235347 0.447358587171447 no 1908 0.463008682063513 2673 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_265 mycophenolic acid 32.932 µM -0.0930181578520969 0.447293173394307 no 1909 0.462944567941738 2771 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2379 9035213 200 µM -0.0933736586411764 0.447149102804895 no 1910 0.46280335821742 2561 646551
SGTC_847 0342-0274 5.54 µM -0.0935797197751555 0.447065597464344 no 1911 0.462721510091178 2668 18097
SGTC_1691 st019933 84.6 µM -0.0936104035522699 0.447053163203394 no 1912 0.462709322533959 2560 6176082
SGTC_1963 st076565 50.3 µM -0.0942561584248313 0.446791490283248 no 1913 0.462452837658842 2579 4914280
SGTC_486 niguldipine 82 µM -0.0953467747220327 0.446349603183207 no 1914 0.462019695500507 2556 1236 A calcium channel blocker.
SGTC_2385 9074692 200 µM -0.098120417830153 0.445226102269849 no 1915 0.460918337336782 2607 17046906
SGTC_2892 9047358 58.44 µM -0.0983260293070229 0.445142834014135 no 1916 0.460836704963262 2625 6466771
SGTC_2130 NSC 7 2.4545 µM -0.0983760866643183 0.445122562219996 no 1917 0.460816831318001 2640 21448
SGTC_204 PMA1.184 62.41 µM -0.0983814454295756 0.44512039208225 no 1918 0.460814703800384 2556 2252213 YGL008C PMA1
SGTC_303 1348-1668 34.2 µM -0.098661898505293 0.445006819371454 no 1919 0.460703360900624 2608 5380509
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.100590876379613 0.444225780295764 no 1920 0.45993761978185 2775 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2549 cedrol 20.94 µM -0.101278081064069 0.443947584724491 no 1921 0.459664857746359 2590 6708665 A sedative which affects the nervous system.
SGTC_2306 7482397 179.52 µM -0.102824191237256 0.443321786490876 no 1922 0.459051252597637 2662 891448
SGTC_26 0302-0163 425.158 µM -0.102936179504794 0.443276463975913 no 1923 0.459006811555644 2604 3100915
SGTC_776 4476-4378 112 µM -0.103034061869693 0.443236850836207 no 1924 0.458967968671475 2682 2892008
SGTC_1790 st045711 43.5 µM -0.103238021796602 0.443154309771356 no 1925 0.458887032043212 2597 585119
SGTC_1228 0124-0032 52.5 µM -0.10375794096937 0.442943913517295 no 1926 0.458680722247441 2648 X1228
SGTC_256 clotrimazole 625 nM -0.107409176635018 0.441466820527462 no 1927 0.457232187361097 2577 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1917 st066507 28.5 µM -0.108510991929235 0.441021244381398 no 1928 0.45679518085068 2585 3156428
SGTC_1548 st061468 90.8 µM -0.108524947736858 0.441015601104512 no 1929 0.456789645974859 2640 390799
SGTC_2374 9071832 200 µM -0.10876049785481 0.440920354068988 no 1930 0.456696228021227 2584 17381698
SGTC_1183 1254-0324 198 µM -0.108865851081397 0.440877754548578 no 1931 0.4566544462529 2694 5799357
SGTC_2412 st077135 33.4 µM -0.108932268981341 0.440850898858087 no 1932 0.456628105993047 2889 13258915
SGTC_750 4073-0104 132 µM -0.109410871243546 0.440657386874555 no 1933 0.456438305754373 2639 22330957
SGTC_1889 st059080 5.18 µM -0.10949315899834 0.440624117111232 no 1934 0.456405673737996 2584 176925 Isolated from Daphnopsis sellowiana.
SGTC_1994 st072947 40.9 µM -0.110529910540993 0.440204984062347 no 1935 0.455994565003322 2726 5286565 YDL195W SEC31
SGTC_3252 9135871 49.47 µM -0.111838299173942 0.439676130524556 no 1936 0.455475809826122 2730 17682838
SGTC_177 1327-0068 8.361 µM -0.112379412722573 0.439457442655539 no 1937 0.455261289091126 2593 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_456 gingerol 170 µM -0.113345844949932 0.439066910740972 no 1938 0.454878186193099 2750 442793 A herb.
SGTC_932 2857-0803 154 µM -0.113980362968519 0.438810536435172 no 1939 0.454626680032548 2833 674898
SGTC_2008 4012253 172 µM -0.114152769632038 0.438740880686858 no 1940 0.454558345729331 2626 603940
SGTC_2181 6316240 54.2555 µM -0.115087982787389 0.438363068937676 no 1941 0.454187692478215 2686 12779990
SGTC_2106 5357045 167.29 µM -0.115360354373382 0.438253045546588 no 1942 0.454079750869788 2726 668842
SGTC_2775 cyproheptadine 69.59 µM -0.118537354164879 0.436970064119918 no 1943 0.4528209496888 2603 2913 A selective serotonin reuptake inhibitor.
SGTC_1171 0368-0077 21.4 µM -0.119284972511381 0.436668246014796 no 1944 0.452524794344861 2614 3239779
SGTC_832 4083-0019 164 µM -0.119596708477998 0.436542407176113 no 1945 0.452401313631803 2732 1990758
SGTC_3241 9133421 49.47 µM -0.119763314910421 0.436475155586287 no 1946 0.452335321590263 2597 17018221
SGTC_3176 9106582 49.47 µM -0.120534275103909 0.436163977261643 no 1947 0.452029964976689 2608 17018027
SGTC_589 1227-0070 34.1 µM -0.122713256431994 0.43528470153923 no 1948 0.451167083047304 2730 2841384
SGTC_2967 9089538 49.85 µM -0.124707024372685 0.434480444371819 no 1949 0.45037774808644 2767 728216
SGTC_3008 9078912 71.4286 µM -0.124860998670015 0.43441834459934 no 1950 0.450316797612664 2650 16648731
SGTC_1021 4476-0760 85.3 µM -0.125536888590041 0.434145768847644 no 1951 0.450049261573556 2635 746768
SGTC_2312 7706453 155.7 µM -0.127189415567554 0.433479462869897 no 1952 0.449395241248795 2670 976098
SGTC_1461 k072-0203 53.8 µM -0.129141224660567 0.432692728655635 no 1953 0.448622951271688 2616 5418714
SGTC_3139 9095020 49.47 µM -0.129843175560844 0.432409851697595 no 1954 0.448345251439334 2599 25236292
SGTC_1907 st060210 83.7 µM -0.130983829831197 0.431950257010011 no 1955 0.447894049557556 2778 688793
SGTC_1416 3966-0321 25.3 µM -0.131456680197082 0.431759762162905 no 1956 0.447707026657935 2689 582530 YLR208W SEC13
SGTC_110 0850-0284 111.64 µM -0.132186855239736 0.431465631403037 no 1957 0.447418248941293 2607 3906265
SGTC_178 4092-0806 87.505 µM -0.132823230705558 0.431209316182995 no 1958 0.447166590846084 2634 2169044
SGTC_3253 9135987 49.47 µM -0.134126925484959 0.430684312949988 no 1959 0.44665110427687 2765 4182430
SGTC_1799 st045822 46.1415 µM -0.136307425791226 0.4298064907299 no 1960 0.445789126872101 2653 3674992
SGTC_55 0767-0285 6.563 µM -0.137117470231267 0.42948047251403 no 1961 0.445468971824035 2695 3116166
SGTC_1872 amphotericin b 148 nM -0.137348092499924 0.429387662859902 no 1962 0.44537782914155 2748 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2152 5568786 200 µM -0.137393838486146 0.429369253700018 no 1963 0.445359750519633 2626 5399883
SGTC_2725 haloperidol 53.21 µM -0.137871519266361 0.429177033956349 no 1964 0.445170979873449 2659 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_111 0083-0039 52.457 µM -0.138362187820012 0.428979605390065 no 1965 0.444977089642184 2635 759313
SGTC_2419 paclitaxel 166.5 µM -0.138716492436091 0.428837056141622 no 1966 0.444837092511428 2606 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1883 5-benzylidenerhodanine 20 µM -0.1388605832742 0.428779085967303 no 1967 0.444780159561537 2741 1273210
SGTC_2564 betulinic acid 100 µM -0.139132563077221 0.428669668093538 no 1968 0.444672698426245 2832 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1951 sophoraflavanone G 9.2 µM -0.13923195153174 0.428629685339763 no 1969 0.444633430362105 2641 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_155 k072-0202 43.6 µM -0.141943082974474 0.427539314344174 no 1970 0.443562481764134 2632 5857737
SGTC_1530 rhein 70.4 µM -0.142773157492358 0.427205582714151 no 1971 0.443234668542873 2640 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_396 dithiazanine 1.25 µM -0.142943099893174 0.42713726375326 no 1972 0.44316755963408 2679 10578 An antihelmenthic.
SGTC_42 0133-0086 60.653 µM -0.143458937535784 0.426929903990938 no 1973 0.442963869424341 2643 162923 Model of phenazepam hydroxylation.
SGTC_2441 5730946 39.09 µM -0.144798474467623 0.426391522675157 no 1974 0.442434993365235 2783 1774275
SGTC_160 3453-0671 289.699 µM -0.14480854401056 0.426387476082885 no 1975 0.442431018094895 2684 5322268
SGTC_2917 7979103 53.79 µM -0.145042868346276 0.426293311630065 no 1976 0.442338512794898 2799 2980565
SGTC_424 splitomicin 100 mM -0.1458059691337 0.42598668476036 no 1977 0.442037281790031 2757 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2572 astragaloside iv 100 µM -0.145875513525823 0.425958742863162 no 1978 0.442009831081209 2850 45006101 An anti-inflammatory agent.
SGTC_1467 k284-1082 293 µM -0.148887785447905 0.424748815657201 no 1979 0.440821089792109 2761 3334705
SGTC_643 k048-0106 28.4 µM -0.149899059527796 0.424342779561702 no 1980 0.440422126861079 2785 6763920
SGTC_1508 1080-0625 72.9 µM -0.15128812089562 0.423785189254592 no 1981 0.439874219788712 2647 767111
SGTC_2480 5767542 37.17 µM -0.151593504721198 0.423662623972045 no 1982 0.439753778339878 2714 2867358
SGTC_499 genistein 192 µM -0.15270614521786 0.423216130143831 no 1983 0.439315007212588 2734 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_892 0929-0076 29 µM -0.153878806373426 0.422745657223247 no 1984 0.438852647560357 2696 5751038
SGTC_2894 9048625 32.47 µM -0.156904056349139 0.421532433977289 no 1985 0.437660231477109 2792 4092861
SGTC_1748 st037455 53.6035 µM -0.159150252702318 0.420632117410653 no 1986 0.436775248397258 2854 580690
SGTC_2370 9071495 200 µM -0.159227718012475 0.42060107527417 no 1987 0.436744733313058 2739 21791103
SGTC_179 1273-0063 6.77 µM -0.159299490209167 0.420572314940209 no 1988 0.436716461192292 2707 3108139
SGTC_2914 7968218 45.32 µM -0.159526856089373 0.420481208383601 no 1989 0.436626900572529 2789 2977111
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.160491851816503 0.420094577608975 no 1990 0.436246819869791 2723 676296 Flavone; oxidizing agent.
SGTC_3196 9111891 49.47 µM -0.160635383130728 0.420037077586541 no 1991 0.436190292533047 2637 18891510
SGTC_2994 9053520 71.4286 µM -0.161488426655185 0.419695375417001 no 1992 0.435854362957973 2818 4647384
SGTC_588 3970-1144 52.9 µM -0.162841793989878 0.41915338371344 no 1993 0.435321500297261 2835 1888707
SGTC_1162 k048-0130 20.1 µM -0.163089461801205 0.419054215167872 no 1994 0.435223998487041 2690 6797406
SGTC_2621 lithochol-11-enic acid 100 µM -0.164683737043891 0.418415975570758 no 1995 0.434596459077144 2706 6708711
SGTC_2829 7992743 58.44 µM -0.165133055910315 0.418236137508858 no 1996 0.434419627652626 2877 16462845
SGTC_3077 9117319 49.47 µM -0.167165004275761 0.417423072336485 no 1997 0.433620109731788 2682 17154678
SGTC_2540 epiandrosterone 100 µM -0.16752766929189 0.417277992334419 no 1998 0.433477439106928 2730 441302 A steroid.
SGTC_1446 4239-0190 62 µM -0.167586795781403 0.417254340524038 no 1999 0.43345417985948 2711 1340085
SGTC_410 α-linolenic acid 100 µM -0.16877719629533 0.416778219675261 no 2000 0.432985947853042 2829 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_186 3455-3465 67.277 µM -0.168972035830598 0.416700301907492 no 2001 0.432909318632668 2700 755278
SGTC_862 0452-0056 10.2 µM -0.171457850654178 0.415706494451878 no 2002 0.431931884960566 2698 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3145 9085516 49.47 µM -0.172858343496335 0.415146826329993 no 2003 0.431381387872756 2783 25236195
SGTC_3132 9126706 49.47 µM -0.173933449532553 0.414717306752536 no 2004 0.430958882177899 2929 850858
SGTC_3038 9091290 49.47 µM -0.173986683928985 0.414696041527082 no 2005 0.430937963652456 2836 25236843
SGTC_1297 1068-0111 14.1 µM -0.175889188973314 0.413936223803741 no 2006 0.430190499445128 2706 767057
SGTC_2040 5100729 123 µM -0.176090136187712 0.413855988761932 no 2007 0.430111565012341 2718 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1397 3532-0190 20.1 µM -0.176141738682413 0.413835385282795 no 2008 0.430091295395182 2684 5322280
SGTC_2341 7987486 176.74 µM -0.177971420957138 0.413104996395509 no 2009 0.429372710089565 2830 1258686
SGTC_35 0133-0054 64.071 µM -0.178970424251417 0.41270633208366 no 2010 0.428980462374009 2753 99677
SGTC_2053 5265679 138 µM -0.179327435283394 0.412563884339652 no 2011 0.428840302885851 2714 764595
SGTC_1840 st055363 71 µM -0.17938731984974 0.412539991467546 no 2012 0.428816793593854 2765 676033
SGTC_1180 1193-0155 285 µM -0.180316962073657 0.412169122447549 no 2013 0.428451870057459 2857 2921347
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.181002179700297 0.411895813717805 no 2014 0.428182932560706 2718 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1591 genipin 88.4 µM -0.181838718950769 0.411562206163646 no 2015 0.427854648855157 2880 442424 A DNA cross-linking agent.
SGTC_6 0844-0013 19.835 µM -0.182075947728476 0.41146761217026 no 2016 0.427761562071908 2771 1584900
SGTC_1764 st044502 93.5 µM -0.183299910663099 0.410979643899925 no 2017 0.427281352245293 2843 8407
SGTC_2779 methotrexate 400 µM -0.183312658879197 0.410974562177771 no 2018 0.427276351173652 2753 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_453 enantio-paf c16 10 µM -0.184851340909773 0.410361319305788 no 2019 0.426672818738101 2840 13871343 A lipid and platelet activating factor
SGTC_3310 9130229 44.1445 µM -0.18529476374092 0.410184633410207 no 2020 0.426498922423505 2892 7761258
SGTC_1850 st056238 17 µM -0.18568374906132 0.410029653650054 no 2021 0.426346386530132 2696 5393177
SGTC_1647 st011722 22.4 µM -0.186031299425569 0.40989119431582 no 2022 0.426210108172694 2884 2854783
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.188361943240005 0.408962988647428 no 2023 0.425296465282209 2699 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_952 1185-0122 232 µM -0.188989229290576 0.408713251710932 no 2024 0.425050629227334 2691 678600
SGTC_1127 asiatic acid 681.4 nM -0.189898136135346 0.408351460867416 no 2025 0.424694476521777 2735 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1491 4138-0063 26.5 µM -0.191749559502103 0.407614742731124 no 2026 0.423969191676011 2730 23883227
SGTC_859 0439-0102 54.6 µM -0.191806662131852 0.407592025639134 no 2027 0.423946826117356 2745 610143
SGTC_2895 9054447 58.44 µM -0.193499428116788 0.40691873540659 no 2028 0.423283926944533 2761 2697450
SGTC_537 1334-0398 209 µM -0.194044936894257 0.406701820182093 no 2029 0.423070348001411 2869 5846986
SGTC_3116 9124943 49.47 µM -0.194345809447217 0.406582193950938 no 2030 0.422952559305727 2766 41905195 YPL160W CDC60
SGTC_1996 st072960 66.8 µM -0.19547946981945 0.40613153160255 no 2031 0.422508804180389 2741 1719405
SGTC_192 3455-0609 60.9 µM -0.195682101092462 0.406050992970826 no 2032 0.422429497411608 2873 3769639
SGTC_230 MPP+ 141.667 µM -0.195868176116883 0.405977038353078 no 2033 0.42235667327388 2780 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_642 0335-0876 158 µM -0.197457861180502 0.405345362747841 no 2034 0.421734627055211 2744 6812350
SGTC_2601 securinine 100 µM -0.197830445494736 0.405197348624221 no 2035 0.421588862422711 2773 442872 A GABA receptor antagonist.
SGTC_2611 pyromycin 23.93 µM -0.20059755380302 0.404098503319688 no 2036 0.4205066354883 2797 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.20143222153078 0.40376719681039 no 2037 0.420180311191868 2861 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1983 st071813 46.9 µM -0.203138806823019 0.403090013239008 no 2038 0.41951327027832 2825 11838595
SGTC_655 k060-0012 42 µM -0.204921683968645 0.402382866920117 no 2039 0.418816656677963 2777 5994525
SGTC_88 0180-0332 8.668 µM -0.20529940992896 0.40223308959203 no 2040 0.418669102524156 2748 3101745
SGTC_1796 st049173 110.4 µM -0.205938346482082 0.401979768735519 no 2041 0.418419535616169 2751 94134
SGTC_1854 st056233 32.9 µM -0.205978170636634 0.401963980910148 no 2042 0.418403981494056 2747 5393174
SGTC_581 0958-0271 211 µM -0.20652840312556 0.401745863989823 no 2043 0.418189090232155 2758 4591145
SGTC_1760 st045453 10.4495 µM -0.207090451328161 0.401523094814108 no 2044 0.417969609598212 2858 3323419 YIL048W NEO1
SGTC_2220 6782180 200 µM -0.207977229873666 0.401171683076273 no 2045 0.417623373269717 2783 833803
SGTC_1702 st027038 51 µM -0.208091055116421 0.401126582302666 no 2046 0.417578935637719 2817 5521182
SGTC_2544 sphondin 68.51 µM -0.208221367443456 0.401074950498579 no 2047 0.417528062703055 3007 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2867 9039098 71.43 µM -0.208310115890891 0.401039787949607 no 2048 0.417493416778841 2753 6463460
SGTC_3309 9129340 25.759 µM -0.208642252309692 0.400908201066579 no 2049 0.417363761907116 2819 17158987
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.208920942317772 0.400797797428879 no 2050 0.417254977645687 2903 5024745
SGTC_733 4069-0007 56.1 µM -0.209142640130422 0.400709977028262 no 2051 0.417168444323247 2786 5717425 YNL287W SEC21
SGTC_1504 k297-0033 30 µM -0.210196761360397 0.400292480298054 no 2052 0.416757053581681 2731 4388117
SGTC_1587 estradiol valerate 56.1 µM -0.210518076973022 0.400165242217797 no 2053 0.416631672193475 2926 13791 A steroid.
SGTC_2245 6637752 200 µM -0.210618690101723 0.400125402505546 no 2054 0.416592413429807 2946 681890
SGTC_2400 5203494 178.7 µM -0.210636036883586 0.400118533817148 no 2055 0.416585644882205 2731 6777674
SGTC_3018 9082602 49.47 µM -0.211217409432599 0.399888349527299 no 2056 0.416358813216015 2767 17332089
SGTC_2842 9000675 19.48 µM -0.212326029209699 0.399449507387195 no 2057 0.415926344987383 2841 2989072
SGTC_1438 4092-1045 4 µM -0.213505211060539 0.398982872970725 no 2058 0.41546646249244 2780 1351342
SGTC_1742 st038235 28.8875 µM -0.214248885432444 0.398688654913884 no 2059 0.415176487984408 2913 564103 YBR002C RER2
SGTC_2164 5685496 200 µM -0.216994512721181 0.397602908989929 no 2060 0.414106310639033 2806 759046
SGTC_2231 micatex 6.853 µM -0.21701784160713 0.39759368707204 no 2061 0.414097220338593 2817 20737 An antifungal of unknown mechanism.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.218620175035962 0.396960421257657 no 2062 0.413472967770195 3080 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3085 9117376 49.47 µM -0.21868262565503 0.396935745339929 no 2063 0.413448642070338 2866 16480349
SGTC_2223 6903751 107.57 µM -0.219470567287473 0.396624443906319 no 2064 0.41314175243737 2887 5598863
SGTC_2718 lomofungin 53.02 µM -0.220543788838316 0.396200539564688 no 2065 0.41272383661047 2956 5351222 A RNA synthesis inhibitor.
SGTC_3249 9135183 49.47 µM -0.221536212595689 0.395808658157591 no 2066 0.412337471703536 2974 4902779
SGTC_3053 9095903 49.47 µM -0.222734029775697 0.395335812688554 no 2067 0.411871257325695 2834 17174018
SGTC_2575 plumbagin 510 nM -0.223177586842139 0.395160754942158 no 2068 0.411698647573429 2758 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2797 7859098 81.82 µM -0.224173127184657 0.394767924186571 no 2069 0.411311296386051 2826 972681
SGTC_774 k060-0086 136 µM -0.224382255447347 0.39468541774364 no 2070 0.411229938401091 2787 5911235
SGTC_286 k060-0067 22.9 µM -0.224492583816426 0.394641892286147 no 2071 0.411187018462753 2828 5985051
SGTC_2873 9040596 71.43 µM -0.224542001030293 0.394622397211468 no 2072 0.411167794524591 2899 6463863
SGTC_2846 9008642 19.48 µM -0.225098906236829 0.394402716545413 no 2073 0.410951165922521 2945 2992898
SGTC_226 1,3-diallylurea 8.28947 mM -0.226067070399966 0.394020887812248 no 2074 0.410574627817628 2892 74537 YKL182W FAS1
SGTC_2278 7948257 134.34 µM -0.226524533773995 0.393840506853323 no 2075 0.410396739951138 2964 1247028
SGTC_1215 3852-0577 11.2 µM -0.22655693428553 0.393827731971677 no 2076 0.4103841414818 2967 2884876
SGTC_817 1391-0715 46 µM -0.22780211637004 0.393336867967491 no 2077 0.409900040663167 2863 1353946
SGTC_2512 diallyl trisulfide 49.23 µM -0.228153426002214 0.393198408602221 no 2078 0.409763483608883 2797 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3290 9121031 71.43 µM -0.229567214113192 0.39264133828457 no 2079 0.409214042910242 2859 17014854
SGTC_1229 0139-0193 12.2 µM -0.229806239557135 0.392547177565899 no 2080 0.40912116800576 2933 3090752
SGTC_1662 st014054 52 µM -0.230238024852783 0.392377097755428 no 2081 0.408953407930926 2810 2838777
SGTC_124 0136-0217 7.121 µM -0.230805458354516 0.392153617507636 no 2082 0.408732970282275 2943 3976905
SGTC_1967 st070177 51.4 µM -0.231690155030366 0.391805256063841 no 2083 0.408389339247309 2988 5729214
SGTC_2478 5763493 32.33 µM -0.231861383172111 0.391737842644497 no 2084 0.408322839490435 2798 1365576 YLR208W SEC13
SGTC_73 0327-0325 16.231 µM -0.234463036606684 0.390713959041569 no 2085 0.407312762989664 2970 53298
SGTC_1287 0971-0001 34.6 µM -0.234463150152814 0.390713914371837 no 2086 0.407312718919448 2827 4665869
SGTC_1816 st051957 91.6 µM -0.234931092809832 0.390529835169536 no 2087 0.407131108135127 2856 674121
SGTC_1327 1436-0082 2.18 µM -0.235466252846503 0.39031934408134 no 2088 0.406923434438061 2849 15992205
SGTC_1418 3966-3099 2.4 µM -0.235935633449162 0.390134752059489 no 2089 0.40674130858477 2900 740335
SGTC_1225 1216-0074 20.6 µM -0.238169715275257 0.389256501013101 no 2090 0.405874732517699 2849 4241466
SGTC_2654 protoveratrine a 100 µM -0.242673916998831 0.387487555144482 no 2091 0.404129007376594 2837 5702278 A heart drug and vasodilator.
SGTC_483 fpl-64176 144 µM -0.242845860965557 0.387420073186127 no 2092 0.404062403423425 2836 3423
SGTC_1656 st012921 11 µM -0.246239509085492 0.386088884197493 no 2093 0.402748416540362 2961 6732821
SGTC_315 k915-0449 187 µM -0.246539837869942 0.385971141844289 no 2094 0.402632184870854 2871 20970215 YNL149C PGA2
SGTC_1954 st077032 68.9 µM -0.246604744367431 0.385945696966089 no 2095 0.402607066229514 2918 698907
SGTC_2715 st079500 56.4 µM -0.248221235115614 0.385312153001582 no 2096 0.401981618572469 2818 28246688
SGTC_1027 k015-0025 8.67 µM -0.248541282111553 0.385186754649522 no 2097 0.401857816675214 2829 3598955
SGTC_1653 st012112 65 µM -0.248908600006967 0.385042849773109 no 2098 0.401715741391157 3011 720429
SGTC_2189 6047310 154.431 µM -0.249027348584835 0.384996330787458 no 2099 0.401669813278438 2811 711535
SGTC_2284 7945075 39.21 µM -0.249234302457327 0.384915261905798 no 2100 0.401589773454404 2993 1245402
SGTC_2416 tofa 880 nM -0.249471918939332 0.384822187936 no 2101 0.401497879896174 2873 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1625 st003711 30.1 µM -0.249740271181369 0.384717082801991 no 2102 0.40139410642973 3056 24207034 YER133W GLC7
SGTC_3344 9148862 3.898 µM -0.252218471184512 0.38374685112595 no 2103 0.400436100780273 3013 4905352
SGTC_1370 2001-0092 44.6 µM -0.252499323995876 0.383636941230891 no 2104 0.400327568278217 3060 790957
SGTC_1230 0170-0365 3.77 µM -0.25338125937282 0.383291862533222 no 2105 0.399986804049952 2956 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1526 st051518 75 µM -0.255795192939221 0.382347826432707 no 2106 0.399054492967513 2915 673993
SGTC_3243 9134147 49.47 µM -0.258953354305624 0.381113795230173 no 2107 0.397835615492715 2920 24282180
SGTC_965 1291-5240 308 µM -0.259836043584799 0.38076910554388 no 2108 0.397495123408408 2987 2834598
SGTC_517 1365-0151 113 µM -0.261033475909713 0.380301660141368 no 2109 0.397033345945459 3042 768657
SGTC_546 peri-Naphthalide 147 µM -0.261805958450266 0.380000196402976 no 2110 0.396735522538529 2937 223824 A penicillin ester.
SGTC_991 3996-0057 64.7 µM -0.26218897464367 0.379850750151683 no 2111 0.396587876556712 2950 715343
SGTC_2358 9037157 4 µM -0.262403841865349 0.379766920556497 no 2112 0.396505055525782 2964 2388925
SGTC_1668 st014914 51.6 µM -0.262697293762982 0.379652440589692 no 2113 0.396391951407327 2916 2839556
SGTC_1523 st012844 44.7 µM -0.264193323900763 0.379068981054749 no 2114 0.395815477563208 2983 4274103
SGTC_2987 9018338 71.43 µM -0.264499839867048 0.378949472184711 no 2115 0.395697394092676 2861 5055682
SGTC_3066 9117245 49.47 µM -0.264638912287408 0.378895252437069 no 2116 0.395643820418398 2915 17176980
SGTC_1938 st074717 56.4 µM -0.265377651192867 0.378607282487633 no 2117 0.395359275450186 2825 17250979
SGTC_2193 5925765 200 µM -0.265882604834232 0.378410483813397 no 2118 0.395164811188768 2993 877370
SGTC_2112 5488546 200 µM -0.266028906782177 0.378353470549039 no 2119 0.395108473268005 2862 600757
SGTC_573 3702-0553 84.7 µM -0.266390225792866 0.378212677372916 no 2120 0.394969346022539 2878 1222756
SGTC_295 k015-0027 31 µM -0.266537637292135 0.378155240994335 no 2121 0.394912588514759 2946 3887424
SGTC_3040 9091894 49.47 µM -0.267638814040506 0.377726271505656 no 2122 0.394488675611213 2878 25236966
SGTC_2062 5245942 200 µM -0.268299360146966 0.377469024422772 no 2123 0.394234449350422 2858 1376160
SGTC_246 cycloheximide 667 µM -0.269955643154394 0.376824230751127 no 2124 0.393597189326406 2868 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.270609002760452 0.376569971145533 no 2125 0.393345885452634 2883 1377
SGTC_1007 4101-0031 70 µM -0.270805563142235 0.376493488725792 no 2126 0.393270290469577 3055 1146276
SGTC_2505 galangin 7.89 µM -0.270880105733385 0.376464485177417 no 2127 0.393241623252681 2832 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.271616868833335 0.37617785781743 no 2128 0.392958313742066 2866 3256 An antibiotic and ribosome inhibitor.
SGTC_1559 coumarin 343 70.1 µM -0.274452529693601 0.375075322115987 no 2129 0.391868439624694 3040 108770 A hepatotoxic, DNA x-linker.
SGTC_3167 9103034 49.47 µM -0.274528120040092 0.375045945687186 no 2130 0.391839398364606 2869 5127859
SGTC_2038 4100038 30.985 µM -0.276916994114932 0.374117939628721 no 2131 0.39092192163353 2996 3596803
SGTC_818 4072-2707 53.5 µM -0.277013494706639 0.374080467321842 no 2132 0.390884872101046 2846 882871
SGTC_2841 9004761 38.96 µM -0.277259745163237 0.373984850786013 no 2133 0.390790333498309 2913 2991039
SGTC_1884 5633444 25 µM -0.277433213139982 0.373917499597458 no 2134 0.390723740866284 3055 5724239
SGTC_19 0279-0214 38.434 µM -0.277954425404569 0.373715155351424 no 2135 0.390523671946895 2902 3566274 YBR002C RER2
SGTC_2269 7935389 174.42 µM -0.278165632439126 0.373633170778133 no 2136 0.390442607730622 2871 97605
SGTC_1672 st016598 6.51 µM -0.278894547451805 0.373350270611662 no 2137 0.390162876546476 2936 4665860 YNL267W PIK1
SGTC_86 0417-1630 471.922 µM -0.27996207439897 0.372936074530918 no 2138 0.389753301020635 2959 3634867
SGTC_1317 1273-0028 910 nM -0.281416117304017 0.372372148127334 no 2139 0.389195628802367 2916 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1726 st035556 14.5795 µM -0.281626876051107 0.372290431515938 no 2140 0.389114814950152 3103 5919439
SGTC_1762 st045503 25.4615 µM -0.282053709010539 0.372124954967978 no 2141 0.388951163767843 2981 4645554
SGTC_414 piperonyl butoxide 100 µM -0.282630525789476 0.371901369529676 no 2142 0.388730038891413 2900 5794 A potent inhibitor of cytochrome P450.
SGTC_2682 pyrogallin 40.03 µM -0.282849250124246 0.371816599000127 no 2143 0.388646199519049 2934 822798 An ATP competetive kinase inhibitor.
SGTC_1552 6-methylflavone 10.6 µM -0.28304627217701 0.371740244898054 no 2144 0.388570683303176 2930 689013
SGTC_391 gliotoxin 8.33 µM -0.283650343756523 0.371506173917501 no 2145 0.388339176092414 3068 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_575 k072-0246 11.9 µM -0.284621410147037 0.371129996149423 no 2146 0.387967103241204 2897 6796779
SGTC_162 k030-0015 37.8 µM -0.284940996562312 0.371006219671712 no 2147 0.3878446732944 2987 1809920 YMR134W ERG29
SGTC_760 0568-0725 82.9 µM -0.286732559414204 0.370312591102806 no 2148 0.387158552545063 3051 3916171
SGTC_1988 st071872 53.4 µM -0.288027348918725 0.369811557504136 no 2149 0.386662901966464 3042 16414116
SGTC_2780 5215298 71.43 µM -0.291047623722464 0.368643687661427 no 2150 0.385507448403099 3066 2834131
SGTC_1247 0448-0043 5.84 µM -0.291350034573105 0.368526819022877 no 2151 0.385391812139075 3039 3089013 YGL099W LSG1
SGTC_379 3970-0972 5.9 µM -0.291759779573014 0.368368489807056 no 2152 0.385235149555527 2959 2898042 YBL034C STU1
SGTC_2792 7535235 81.82 µM -0.292309591219598 0.368156072676826 no 2153 0.385024963086314 3001 1281891
SGTC_534 k292-0788 63.4 µM -0.292375718168143 0.368130527556676 no 2154 0.384999685812848 3087 4146317
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.292595871793329 0.368045485481777 no 2155 0.384915534788472 2902 364106
SGTC_1627 st003713 25.6 µM -0.29274178133729 0.367989126355338 no 2156 0.3848597656405 2997 16195070 YER133W GLC7
SGTC_2017 5132927 60.65 µM -0.292902444888707 0.36792707162235 no 2157 0.38479836001162 2933 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2662 daunorubicin 22.37 µM -0.293983723199215 0.367509528129397 no 2158 0.384385170546319 2908 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_555 4296-0685 37 µM -0.294378426601507 0.367357149520779 no 2159 0.384234375016651 2959 2908540 YHR072W ERG7
SGTC_1032 k061-1018 98.7 µM -0.294925755969698 0.367145882923718 no 2160 0.384025298083634 3121 4005393
SGTC_67 0335-0847 266 µM -0.295437242942275 0.366948487678059 no 2161 0.383829943259886 3257 4552207 YOR254C SEC63
SGTC_276 colchicine 750 µM -0.295555264103293 0.366902945437837 no 2162 0.383784871026581 3054 2833 A microtubule depolymerizer.
SGTC_135 0933-0004 26.348 µM -0.296045975915941 0.366713608680202 no 2163 0.383597485249646 3041 21230617 YGL099W LSG1
SGTC_2606 farnesol 9.78 µM -0.296968577518092 0.366357718939932 no 2164 0.38324524951239 3107 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1426 4048-4480 71.7 µM -0.297251979851575 0.366248420720648 no 2165 0.38313707002521 3039 14224343
SGTC_1 0258-0098 57.368 µM -0.298878079845669 0.365621501654012 no 2166 0.382516536414325 2985 6790032 YDR047W HEM12
SGTC_2490 carminic acid 95.39 µM -0.298996551266292 0.365575840732337 no 2167 0.382471338476509 2893 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2769 toremifene 3.73 µM -0.300303016776729 0.36507243292388 no 2168 0.381973016158939 3132 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_594 1487-1584 10.8 µM -0.301072642615679 0.364775989132284 no 2169 0.381679550880012 2949 5013332
SGTC_2518 prenyletin 46.28 µM -0.301452687406166 0.364629633619617 no 2170 0.381534661438373 3038 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1893 st059353 36.1 µM -0.301699065662925 0.36453476372085 no 2171 0.381440740303075 2997 3112488
SGTC_943 3253-1379 105 µM -0.301712154899179 0.364529723838822 no 2172 0.381435750788819 3126 668464
SGTC_503 tyrphostin 8 294 µM -0.302474900380733 0.364236076640065 no 2173 0.381145032245297 3054 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2462 5162487 171.77 µM -0.304099617922896 0.363610847095903 no 2174 0.380525998958973 2904 2259986
SGTC_2195 6536160 144.242 µM -0.304187952879772 0.363576864117473 no 2175 0.380492351226698 2916 3834386
SGTC_2888 9058547 12.99 µM -0.30433055321808 0.363522007192155 no 2176 0.380438035136693 2939 16476514
SGTC_2513 baicalein 25.65 µM -0.306543015878809 0.362671254056329 no 2177 0.379595616598129 2995 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_292 k038-0015 474 µM -0.307124661561774 0.36244770749146 no 2178 0.379374243518368 3065 46368540
SGTC_2622 2-methoxyxanthone 59.94 µM -0.308737427924578 0.361828111036619 no 2179 0.378760635188232 2997 71034 A hepatoprotective.
SGTC_1787 fluconazole 80 µM -0.309921531571342 0.36137342961849 no 2180 0.378310314305426 3028 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1786 berberine 21.6 µM -0.30997313259933 0.361353619896519 no 2181 0.378290693914341 2934 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1104 tacrolimus 29.8 µM -0.311147413435295 0.360902912073703 no 2182 0.377844279028025 2993 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3262 9137218 49.47 µM -0.31184289236089 0.360636067106866 no 2183 0.377579962450169 2871 17650664
SGTC_1636 st007707 68.9 µM -0.312137417827814 0.360523082487975 no 2184 0.377468045395953 3160 403051
SGTC_737 1950-0117 57.9 µM -0.312205160953931 0.360497096877366 no 2185 0.377442305066412 3094 5393513
SGTC_2706 st078239 82.5 µM -0.312491064494204 0.360387434132061 no 2186 0.377333676406717 2958 15434492
SGTC_2192 5915882 198.485 µM -0.31368724927357 0.359928743502362 no 2187 0.37687929296661 2943 2876149
SGTC_720 r052-1644 49.9 µM -0.31369838280434 0.359924475169737 no 2188 0.376875064576972 3073 1422863 YOR257W CDC31
SGTC_2773 thioridazine 9.09 µM -0.313755592026507 0.359902542781234 no 2189 0.376853337391407 2959 5452 An antipsychotic.
SGTC_3332 9141069 11.198 µM -0.31432243859839 0.35968525486704 no 2190 0.376638078839218 2928 17332883
SGTC_2963 9082507 9 µM -0.315843327091332 0.359102480630792 no 2191 0.376060714937645 3131 16459611
SGTC_3103 9120822 49.47 µM -0.317305006171848 0.358542703049879 no 2192 0.375506089557976 3186 17141819
SGTC_598 3937-0236 20.2 µM -0.31795159398759 0.358295176888662 no 2193 0.37526082766166 3034 1379313
SGTC_2927 9011802 47.9 µM -0.319325522060038 0.357769408765775 no 2194 0.374739840576341 3070 43912568
SGTC_1602 st001878 87.6 µM -0.319423153261247 0.357732057985087 no 2195 0.37470282796841 3137 595405 YLR310C CDC25
SGTC_833 3852-0053 558 µM -0.319710122900984 0.357622279862569 no 2196 0.374594042640571 3133 3123681
SGTC_1068 loratadine 26.9 µM -0.320139898266779 0.357457894490967 no 2197 0.374431140750083 3017 3957 A H1 histamine antagonist.
SGTC_973 1325-0077 65.9 µM -0.3227459134156 0.356461683479912 no 2198 0.373443838708039 3016 2835149
SGTC_1256 0570-0116 285 µM -0.324077018870027 0.355953214026451 no 2199 0.372939862552152 3005 410638
SGTC_2160 5660466 132.927 µM -0.324079583003837 0.355952234798918 no 2200 0.372938891942775 3043 2859134
SGTC_2120 5538279 151.968 µM -0.325450719456234 0.355428742164841 no 2201 0.37241998716323 3005 2058197
SGTC_2950 9072895 21.46 µM -0.326594077863993 0.354992422390839 no 2202 0.371987461657189 3108 17332245
SGTC_972 1319-0219 195 µM -0.32879427937092 0.354153333436584 no 2203 0.371155593653676 3061 23903702
SGTC_332 4112-0506 40.9 µM -0.329990906363612 0.353697273651291 no 2204 0.370703416646481 2981 2790355
SGTC_2768 sulfasalazine 50.2 µM -0.331043218267736 0.353296388809961 no 2205 0.370305920397462 3120 5384001 An antioxidant and salicylic acid derivative.
SGTC_357 1325-0123 420 µM -0.331642176807757 0.353068284422235 no 2206 0.37007973390604 3111 1098503
SGTC_1867 st057372 64 µM -0.332895525975606 0.352591136053481 no 2207 0.369606573386678 2996 688837
SGTC_2154 5570129 200 µM -0.333229904778685 0.352463877630765 no 2208 0.369480373056331 3017 673366
SGTC_2817 7995342 71.43 µM -0.333442309865083 0.352383048736567 no 2209 0.369400215013501 2934 18879975
SGTC_3166 9102297 49.47 µM -0.334207105197096 0.352092067812818 no 2210 0.369111641393424 3049 25237072
SGTC_1266 0828-0227 32.9 µM -0.334979815269713 0.351798163502911 no 2211 0.368820156271915 3102 3913820
SGTC_2433 5607874 27.82 µM -0.335515761939494 0.351594365380562 no 2212 0.368618028390029 2991 2252428
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.336484855477728 0.35122596791137 no 2213 0.368252635032089 3004 229346 A bile salt which induces apoptosis.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.337502511295185 0.350839260090497 no 2214 0.367869059674776 3063 688801
SGTC_2957 9076800 11.52 µM -0.340271638669241 0.349787778477718 no 2215 0.366825986634764 3033 16459615
SGTC_1139 k015-0024 46.9 µM -0.341606825244182 0.349281197733718 no 2216 0.366323400047131 3139 2766652
SGTC_2246 7293507 91.5585 µM -0.342802141122 0.34882791272494 no 2217 0.365873657535592 3160 887656
SGTC_1769 st044406 64.4 µM -0.343317747928077 0.348632452011121 no 2218 0.365679715201964 2992 670903
SGTC_3159 9100096 49.47 µM -0.344603930550923 0.34814504991358 no 2219 0.365196075225469 2917 25236875
SGTC_2185 6113692 200 µM -0.344739756241763 0.348093593053987 no 2220 0.365145013535704 3144 874150
SGTC_232 clozapine 119 µM -0.346104809852673 0.347576604997443 no 2221 0.364631974413512 3017 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1571 st070080 73.4 µM -0.348391286909903 0.346711280558749 no 2222 0.363773172597399 3165 4315245
SGTC_3325 9138760 55.175 µM -0.348812168064877 0.346552083711802 no 2223 0.363615163852381 3036 43844959
SGTC_978 1416-0512 87.4 µM -0.349527402150621 0.346281611045167 no 2224 0.363346701266195 3098 6814003
SGTC_709 3807-1509 243 µM -0.349674104181701 0.346226143939658 no 2225 0.363291645056771 3063 1886677 YPL242C IQG1
SGTC_2519 cryptotanshinone 88.04 µM -0.349960154720699 0.346117999535581 no 2226 0.363184300485061 3171 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2532 xanthone 78.9 µM -0.350474023787519 0.345923757472338 no 2227 0.362991490735043 3135 7020 An insecticide.
SGTC_1666 st014829 29 µM -0.351112828603624 0.345682346330702 no 2228 0.36275185202997 2983 3858230
SGTC_1733 st037357 54.9 µM -0.352111420976832 0.345305093359288 no 2229 0.362377351751032 2942 1272339 YGL099W LSG1
SGTC_685 1278-0033 54.9 µM -0.352488051778783 0.34516284786772 no 2230 0.362236138761887 3161 3590572
SGTC_795 0685-0265 78 µM -0.35283168968206 0.345033082178566 no 2231 0.362107312399903 3019 302754
SGTC_1363 1636-0063 10.4 µM -0.354719793927541 0.344320415440817 no 2232 0.36139976030509 3050 6072185
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.356126510415033 0.34378980790567 no 2233 0.360872912284174 3015 442882
SGTC_3115 9123671 49.47 µM -0.358240830885538 0.342992873887109 no 2234 0.36008154675889 3131 3286988
SGTC_1151 3909-8316 15.3 µM -0.360298210738199 0.342218071930995 no 2235 0.359312068611111 3144 800431
SGTC_97 0535-0701 19.132 µM -0.360813246548379 0.342024215021416 no 2236 0.359119529814737 3058 2832013 YGL099W LSG1
SGTC_1313 1220-0047 237 µM -0.360946236155504 0.341974165158258 no 2237 0.359069819355641 3093 3528706
SGTC_2568 diosmetin 100 µM -0.360983837654599 0.34196001455684 no 2238 0.35905576464654 3204 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1238 0333-0287 48.8 µM -0.361175753591508 0.341887794141379 no 2239 0.358984033173659 3061 7226
SGTC_2855 9016525 58.44 µM -0.361929800289088 0.341604092792539 no 2240 0.35870224502572 3001 43811474
SGTC_3155 9099265 49.47 µM -0.362461353218461 0.341404155897437 no 2241 0.358503649262853 3144 25236499
SGTC_2066 5222451 176 µM -0.363505092489407 0.341011696130052 no 2242 0.358113804734604 3029 2281147
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.364664685633054 0.340575875432794 no 2243 0.357680861336426 3232 688751
SGTC_1750 st081859 2.357 µM -0.366308670854492 0.339958365898656 no 2244 0.3570673800876 3090 5291695
SGTC_600 1495-0418 41.6 µM -0.366562947988658 0.339862893249792 no 2245 0.356972525163004 3050 5377768
SGTC_1257 0669-0121 16 µM -0.366821545071199 0.339765809136972 no 2246 0.356876067802843 3112 4307855
SGTC_2391 6285546 200 µM -0.368790410744974 0.339026994342012 no 2247 0.356141976388019 3018 846083
SGTC_2980 9014342 25.29 µM -0.371227151496716 0.338113466716361 no 2248 0.355234175859614 3205 2996599
SGTC_1794 st048918 76.9 µM -0.371399751216732 0.338048795597356 no 2249 0.355169905421082 3125 672303
SGTC_2508 celastrol 40.54 µM -0.37242779885938 0.337663697098332 no 2250 0.35478717981824 3101 122724 Celastrol is a natural product and antioxidant.
SGTC_4 0960-0234 25.671 µM -0.374721622350066 0.336805061981912 no 2251 0.353933754876384 3147 6821112
SGTC_2475 5812728 15.03 µM -0.374989739004919 0.33670475464891 no 2252 0.353834048937906 3036 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1622 st003707 19.4 µM -0.375577675570519 0.336484837523402 no 2253 0.353615445001181 3181 10140899
SGTC_1080 nisoldipine 24.4 µM -0.377810684971462 0.335650092517572 no 2254 0.352785617791819 2996 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1926 methyl fluorone black 53.6 µM -0.378503128325978 0.33539140731496 no 2255 0.35252843513411 3083 72721 Reacts with homocysteine.
SGTC_1391 3442-0225 151 µM -0.378814038145699 0.335275282003966 no 2256 0.352412981016212 3046 5227075
SGTC_2727 riluzole 51.77 µM -0.380125988920457 0.334785439750179 no 2257 0.351925947418726 3108 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1108 betulinic acid 729.144 nM -0.381057142781639 0.334437945839211 no 2258 0.351580423802736 3106 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3158 9100007 49.47 µM -0.381511897846453 0.33426828897472 no 2259 0.351411722203102 3065 19297233
SGTC_1097 itavastatin 7.23 µM -0.381769851711189 0.334172068380785 no 2260 0.351316041433291 3104 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_250 brefeldin a 552.239 µM -0.38219995784446 0.334011656687956 no 2261 0.351156526550602 3051 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2614 arthonioic acid 13.39 µM -0.382656167036148 0.33384154277749 no 2262 0.35098735939611 3084 6710684
SGTC_478 N-arachidonylglycine 10 µM -0.383018832522348 0.333706334340416 no 2263 0.350852900295209 3149 5283389
SGTC_2372 9071633 200 µM -0.383150144574015 0.33365738408925 no 2264 0.350804220640849 3211 21321366
SGTC_360 0957-0399 1.01 µM -0.384471974206229 0.333164792835736 no 2265 0.350314332010178 3207 6752301 YPR165W RHO1
SGTC_136 0097-0015 404.482 µM -0.384484227629789 0.333160227835838 no 2266 0.350309791882503 3177 4861337
SGTC_3052 9092717 49.47 µM -0.384724875173613 0.333070579860125 no 2267 0.350220631702844 3227 25237534
SGTC_3227 9130768 49.47 µM -0.385539649817921 0.332767124243175 no 2268 0.349918818111865 3080 17720899
SGTC_1154 4088-0362 150 µM -0.385906588579793 0.332630496899494 no 2269 0.34978292545689 3052 6618304
SGTC_3121 9125696 49.47 µM -0.386335526533457 0.332470812725492 no 2270 0.349624096321686 3126 1235365
SGTC_1189 1431-2119 7.28 µM -0.38655596724154 0.332388759318178 no 2271 0.349542480750381 3126 3107275
SGTC_508 roscovitine 141 µM -0.386603760810442 0.332370970445698 no 2272 0.349524786662607 3076 160355 A CDKinase inhibitor.
SGTC_1269 0831-0796 3.05 µM -0.389467331076215 0.331305833540425 no 2273 0.348465236360207 3211 927758
SGTC_3295 9122362 53.5725 µM -0.389705149454766 0.331217435535748 no 2274 0.348377294139803 3175 4730473
SGTC_2993 9054257 71.4286 µM -0.39456602359471 0.329412696614428 no 2275 0.346581596218453 3078 6470217 YGL055W OLE1
SGTC_3191 9110352 49.47 µM -0.395413654183929 0.329098394443149 no 2276 0.346268816905922 3150 17122424
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.395457811377063 0.329082024224735 no 2277 0.346252525583553 3235 688664
SGTC_1697 st025554 27.742 µM -0.397309021844419 0.328396027655628 no 2278 0.345569797642583 3071 1269519
SGTC_510 ag-490 170 µM -0.397399046528806 0.328362682246916 no 2279 0.345536609247937 3203 5328779
SGTC_2352 9027995 87.8 µM -0.39871544139527 0.32787524199197 no 2280 0.345051444393771 3156 2997347
SGTC_2037 5169046 200 µM -0.399454361465462 0.327601759917908 no 2281 0.344779222689349 3208 5718022
SGTC_596 1155-0152 116 µM -0.399687559122517 0.327515470206144 no 2282 0.344693328223945 3146 280313
SGTC_1901 st060216 58.6 µM -0.399876499201765 0.327445563802764 no 2283 0.344623741169276 3080 688792
SGTC_2079 5212404 121 µM -0.401085861843405 0.326998252138305 no 2284 0.344178454807408 3247 758462
SGTC_496 calpeptin 138 µM -0.401115544179956 0.326987276538158 no 2285 0.344167528507487 3160 73364 A calpain inhibitor.
SGTC_445 e6 berbamine 66 µM -0.40197933417758 0.326667939580444 no 2286 0.343849617673016 3190 6610268 A calcium/calmodulin antagonist.
SGTC_580 1123-0028 41 µM -0.40294873804804 0.326309709110352 no 2287 0.343492967961505 3112 1677248 YPR107C YTH1
SGTC_842 0271-0008 11.1 µM -0.40453482188952 0.325723938176274 no 2288 0.342909738363237 3244 1221709
SGTC_2238 6671620 73.2395 µM -0.40603455153144 0.325170454966362 no 2289 0.342358606728601 3045 729941
SGTC_2383 9036125 200 µM -0.407194535053662 0.324742621191509 no 2290 0.341932557540082 3106 79580
SGTC_2806 7952793 58.44 µM -0.407529772067025 0.324619019596639 no 2291 0.341809466125779 3253 2972490
SGTC_1044 1222-0021 1.78 µM -0.408188520205951 0.324376196001827 no 2292 0.341567637773867 3188 4306703
SGTC_2253 7938677 135.83 µM -0.408785221137057 0.324156308297128 no 2293 0.341348643249277 3276 2301972
SGTC_926 2268-1401 59.4 µM -0.40978899381702 0.323786550700476 no 2294 0.340980370318164 3186 2931578
SGTC_3079 9117512 49.47 µM -0.413011731906358 0.322600574130611 no 2295 0.339799009139934 3187 7185044
SGTC_2973 9094665 17.96 µM -0.413464974222709 0.322433924013671 no 2296 0.339632989617142 3319 25237061 YIL048W NEO1
SGTC_1119 parthenolide 318.541 nM -0.41441789267359 0.322083667169208 no 2297 0.339284043677551 3311 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2452 5863136 48.41 µM -0.414733646505293 0.321967642809237 no 2298 0.339168449241343 3095 2184096
SGTC_1089 terbinafine 2.25 µM -0.416481949971343 0.321325539579661 no 2299 0.338528686373188 3232 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3010 9080089 71.4286 µM -0.416793080408227 0.321211325906617 no 2300 0.338414882075144 3224 17027233
SGTC_3312 9133330 71.43 µM -0.417257729518594 0.321040788151427 no 2301 0.338244951684815 3269 17617324
SGTC_696 1560-0013 611 µM -0.420155349437332 0.319978142442556 no 2302 0.337185985348927 3321 1650269
SGTC_337 1315-0038 354 µM -0.420410952862467 0.319884475550252 no 2303 0.337092634065003 3172 1626437
SGTC_1664 st014217 9.02 µM -0.421622837431552 0.319440531995666 no 2304 0.336650167135746 3256 3982782
SGTC_780 0109-0199 192 µM -0.42267131554346 0.319056656979087 no 2305 0.336267543310672 3305 610414
SGTC_3051 9093778 49.47 µM -0.423225508489081 0.318853830906121 no 2306 0.336065368710756 3204 17217378
SGTC_2756 carbadox 75.1 µM -0.42521027227752 0.318127883281805 no 2307 0.335341698259666 3166 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1173 0443-0020 122 µM -0.427937951462384 0.31713134604718 no 2308 0.334348147762814 3142 5331295
SGTC_244 nsc-207895 1.295 µM -0.428583610731834 0.31689565287371 no 2309 0.334113137373677 3131 42640
SGTC_158 k038-0087 26.446 µM -0.429608738534489 0.316521590134129 no 2310 0.333740139679854 3105 X158
SGTC_312 4092-0653 6.84 µM -0.429616031482835 0.316518929654386 no 2311 0.333737486693404 3234 1148278
SGTC_1172 0370-0043 85 µM -0.430119472651443 0.316335296429441 no 2312 0.333554367883522 3275 376585
SGTC_2091 4-phenylthiadiazole 200 µM -0.431118577062967 0.315971001155125 no 2313 0.333191076816729 3140 270010
SGTC_1004 4084-0029 199 µM -0.431434784846772 0.31585574209411 no 2314 0.333076130958807 3277 716894 YLR208W SEC13
SGTC_1660 st012960 28.1 µM -0.43731264440552 0.313716506767888 no 2315 0.330942313282072 3245 24207266
SGTC_2168 5727979 200 µM -0.438022527318673 0.313458567776956 no 2316 0.330684976661029 3213 695210
SGTC_1680 diphenhydramine 100 µM -0.440004501748021 0.312738891973371 no 2317 0.329966923422218 3180 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2018 5133068 143 µM -0.441690145150697 0.312127378178828 no 2318 0.329356720963663 3146 785362
SGTC_1406 3909-7906 11.9 µM -0.44184496111146 0.312071240316977 no 2319 0.329300700377007 3234 X1406
SGTC_3046 9092212 49.47 µM -0.442024251867821 0.312006233095668 no 2320 0.329235828305965 3248 25236637
SGTC_3182 9108849 49.47 µM -0.442763846911011 0.3117381327183 no 2321 0.328968277895619 3282 17133045
SGTC_2719 novobiocin 32.65 µM -0.446048130729366 0.310548798882802 no 2322 0.327781239600615 3306 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_601 0986-0029 62.9 µM -0.447075202188712 0.310177272032904 no 2323 0.327410381482387 3220 24747981
SGTC_1754 st042065 16.137 µM -0.447802491061209 0.309914303892043 no 2324 0.327147872726894 3284 1126236 YIL048W NEO1
SGTC_2902 5787006 60.46 µM -0.448203571054179 0.309769325710821 no 2325 0.327003142863375 3141 591003
SGTC_195 4234-0266 16.654 µM -0.448673816846638 0.309599383881315 no 2326 0.326833487628273 3203 2303354
SGTC_1522 st012842 45.6 µM -0.450580815482591 0.30891063232705 no 2327 0.326145848020692 3123 3491067 YOR116C RPO31
SGTC_1749 st037932 54.2 µM -0.453736549427273 0.307772349950805 no 2328 0.3250092285304 3306 594497
SGTC_2786 7743617 45.45 µM -0.456261329215271 0.306862984227778 no 2329 0.324101034210852 3194 583674
SGTC_3229 9132204 49.47 µM -0.458928518303494 0.30590361535273 no 2330 0.323142749337628 3195 17682924
SGTC_365 0121-0052 13.6 µM -0.459284962320769 0.305775505607598 no 2331 0.323014772517298 3313 3101739
SGTC_1448 4255-0083 152 µM -0.461414164075659 0.305010743401065 no 2332 0.322250745704938 3350 5399660
SGTC_2904 7225135 42.03 µM -0.464277178674567 0.30398375326705 no 2333 0.321224586129842 3336 4446116
SGTC_1038 k292-0204 154 µM -0.464365254605644 0.303952184061838 no 2334 0.321193039597721 3165 4454212
SGTC_3087 9117406 49.47 µM -0.465623136259979 0.30350147903686 no 2335 0.32074263964466 3305 42546093
SGTC_1141 3253-0389 52.6 µM -0.465853877481078 0.303418835761781 no 2336 0.320660048529157 3292 5402031
SGTC_922 1866-0035 480 µM -0.465867069819363 0.303414111040633 no 2337 0.320655326754552 3202 3156169
SGTC_908 3448-7491 47.7 µM -0.46631128984029 0.303255036699049 no 2338 0.320496349382032 3218 1203031
SGTC_370 0180-0345 38.7 µM -0.466830301919192 0.303069226708849 no 2339 0.32031064715507 3133 3989527
SGTC_435 c-PAF 6.7 µM -0.468191026075542 0.302582319842005 no 2340 0.319823994516406 3308 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1711 st032263 62.8 µM -0.468622570947264 0.302427973733414 no 2341 0.319669720477954 3267 3958979
SGTC_2872 9044037 25.97 µM -0.469676404596424 0.302051208619409 no 2342 0.319293114044792 3241 6465195
SGTC_484 loperamide 105 µM -0.471051764856065 0.301559809087123 no 2343 0.318801884657737 3238 3955 An opioid-receptor agonist.
SGTC_92 0063-0024 660.874 µM -0.47134323783654 0.301455715531702 no 2344 0.318697821788171 3293 3594437
SGTC_2250 alverine citrate 130 µM -0.472023674571173 0.301212774568046 no 2345 0.318454945148396 3272 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1873 rapamycin 2 nM -0.472356671929429 0.301093914402462 no 2346 0.318336112731389 3257 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2085 5307070 144.047 µM -0.473097630757331 0.300829512235193 no 2347 0.318071763511905 3192 2840351
SGTC_995 3931-2021 34.6 µM -0.473975457447476 0.300516406048592 no 2348 0.317758704347886 3297 730143
SGTC_1405 3909-7894 12 µM -0.474226458387397 0.30042690525093 no 2349 0.317669213864438 3327 7104060
SGTC_493 zm226600 134 µM -0.476453126111951 0.299633457812583 no 2350 0.316875796970613 3385 5240098 A potassium channel opener. YCR052W RSC6
SGTC_460 trequinsin 123 µM -0.476774315834057 0.299519083946167 no 2351 0.316761418470284 3347 5537 A vasodilator.
SGTC_1193 1488-0126 41.5 µM -0.477384386298609 0.299301895768882 no 2352 0.316544215216754 3253 1384710
SGTC_1324 1418-0026 34.4 µM -0.478143015205833 0.299031919732763 no 2353 0.316274208967004 3312 1372513
SGTC_1298 1079-1278 263 µM -0.478329325054534 0.298965633883954 no 2354 0.316207913754206 3315 2840950
SGTC_2043 5101342 149 µM -0.478676610476713 0.298842093503929 no 2355 0.316084353873573 3254 678451
SGTC_710 3448-4187 58 µM -0.479570460809462 0.298524229478968 no 2356 0.315766427410427 3324 3946412
SGTC_1041 0206-0046 107 µM -0.47964949435506 0.298496131593369 no 2357 0.31573832315534 3268 50494
SGTC_140 0062-0056 502.533 µM -0.483703862683618 0.297056345849375 no 2358 0.314298025742483 3216 3758964
SGTC_872 0588-0139 234 µM -0.48584961104108 0.296295635995005 no 2359 0.313536898359458 3261 2047100
SGTC_2585 alliin 100 µM -0.486682806837433 0.296000492729051 no 2360 0.313241565606754 3429 87310 A garlic compound which reacts with lipids.
SGTC_574 1315-0397 40 µM -0.488001828524399 0.295533531326905 no 2361 0.312774272948413 3290 6794277
SGTC_2056 5235370 200 µM -0.491843129781235 0.294175563454596 no 2362 0.311415122057395 3239 5511916
SGTC_1368 1852-0141 284 µM -0.492443222745584 0.293963680635776 no 2363 0.311203025085169 3346 2838987
SGTC_1911 st060208 74.3 µM -0.493969125704097 0.29342522784622 no 2364 0.310663992056887 3328 688783
SGTC_168 3970-0862 530.542 µM -0.494938971221139 0.293083231417323 no 2365 0.310321600210043 3334 3135186
SGTC_731 3966-0296 387 µM -0.495639911092577 0.29283617428804 no 2366 0.310074244420413 3288 660956
SGTC_2647 atorvastatin 60.16 µM -0.496379728530027 0.292575519078672 no 2367 0.309813262266665 3330 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1564 D-Arginine 115 µM -0.497234170332871 0.292274613212983 no 2368 0.309511963827755 3293 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2268 7933382 153.85 µM -0.499660365187508 0.291420974076605 no 2369 0.308657122518346 3360 935025 YOR257W CDC31
SGTC_1594 piperine 70.1 µM -0.499838156175262 0.291358465368871 no 2370 0.308594520630291 3274 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_652 0437-0092 114 µM -0.500002539264493 0.291300676249068 no 2371 0.308536644739571 3339 3091274
SGTC_78 0336-0123 156.75 µM -0.503292306057062 0.290145280300517 no 2372 0.307379387519904 3141 6765896
SGTC_944 3370-0224 231 µM -0.5035174308733 0.290066292988613 no 2373 0.307300264154516 3310 4580514
SGTC_3247 9135149 49.47 µM -0.504385957533184 0.2897616561408 no 2374 0.306995091996467 3303 8934436 YOR116C RPO31
SGTC_11 0438-0307 1.3 µM -0.50493440322935 0.289569365464875 no 2375 0.306802454767177 3396 4011476
SGTC_1150 3909-7983 10.9 µM -0.505601755897689 0.289335465627338 no 2376 0.306568124344704 3288 23965914
SGTC_1466 k213-0079 57.5 µM -0.506039091371517 0.2891822324791 no 2377 0.306414603725414 3341 3657981
SGTC_60 0986-0278 202 µM -0.506661194243915 0.288964326483681 no 2378 0.306196281582895 3230 3110598
SGTC_20 0481-0013 4.944 µM -0.507753056472163 0.288582063248035 no 2379 0.305813267453592 3359 182045
SGTC_884 0851-0618 334 µM -0.508039895779066 0.288481679738736 no 2380 0.305712682346918 3381 9642473
SGTC_47 0149-0135 24.25 µM -0.508047876218104 0.288478887105504 no 2381 0.305709884079073 3281 5239155
SGTC_3055 9094636 49.47 µM -0.509127664630128 0.288101149116397 no 2382 0.305331370837427 3454 25236176
SGTC_420 mitomycin C 81.9 mM -0.509214310536898 0.288070848249963 no 2383 0.305301006655257 3275 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2144 5628481 200 µM -0.509601967038913 0.287935299644716 no 2384 0.305165172760165 3306 2818399
SGTC_10 0279-0212 42.575 µM -0.511181884119815 0.287383174963672 no 2385 0.304611851333024 3342 39851 YBR002C RER2
SGTC_1483 3453-0561 55.9 µM -0.5118115275133 0.287163276703156 no 2386 0.304391460908243 3384 4546991
SGTC_2458 5808907 16.39 µM -0.512392099232664 0.286960586970075 no 2387 0.304188309680919 3445 2731747
SGTC_1015 4130-4525 82 µM -0.513183949667121 0.286684244724286 no 2388 0.303911326109041 3284 1363237
SGTC_732 3970-1727 52.7 µM -0.514284065535372 0.286300532681775 no 2389 0.303526700313342 3397 1275699
SGTC_679 0422-0091 41.4 µM -0.515846151288372 0.285756108361598 no 2390 0.302980933071684 3305 627384 YHR062C RPP1
SGTC_764 1951-2361 146 µM -0.515857702187642 0.28575208443115 no 2391 0.302976899012323 3294 5438930
SGTC_741 4582-0002 126 µM -0.516578773867418 0.285500941580271 no 2392 0.302725118086919 3303 2912688
SGTC_1629 st005085 44.9 µM -0.516976337101792 0.285362518796391 no 2393 0.302586338642427 3279 24207091
SGTC_2723 salbutamol 83.58 µM -0.519134694791868 0.284611584437809 no 2394 0.301833407748845 3371 9884233 β2-adrenoceptor agonist
SGTC_1009 4106-0057 9.87 µM -0.519470595151648 0.284494803111592 no 2395 0.301716306561219 3439 2928005
SGTC_1671 st016596 74.5 µM -0.520828005224611 0.284023110292867 no 2396 0.301243296069926 3417 2829167
SGTC_524 r073-0010 27.8 µM -0.521568893710036 0.283765813402982 no 2397 0.300985263024378 3300 2772106
SGTC_2473 5854593 8.94 µM -0.521895355671815 0.283652474627113 no 2398 0.300871596072528 3272 2872951
SGTC_2880 9042983 58.44 µM -0.522669229666192 0.283383893135884 no 2399 0.300602227361406 3421 6464714
SGTC_789 1309-1135 70.6 µM -0.523500261970895 0.283095610061002 no 2400 0.300313084386443 3408 3092424
SGTC_856 0433-0016 11.3 µM -0.523520956252802 0.283088433061525 no 2401 0.300305885781757 3382 3911780
SGTC_3214 9129694 49.47 µM -0.523619143917531 0.283054381713715 no 2402 0.300271731797056 3421 17158655
SGTC_1289 0976-0073 69.1 µM -0.52470004463 0.282679656824042 no 2403 0.299895863143421 3416 3391136
SGTC_614 0462-0418 107 µM -0.524970481758347 0.282585939421292 no 2404 0.299801855594985 3307 5188303
SGTC_390 dec-rvkr-cmk 16.7 µM -0.525385630124505 0.282442102790689 no 2405 0.299657570462062 3373 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3209 9113616 49.47 µM -0.52567612285854 0.282341476593415 no 2406 0.299556628201352 3475 16649353
SGTC_608 k048-0125 159 µM -0.525816076921424 0.282293002897264 no 2407 0.299508001575791 3423 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1174 0739-0097 51.1 µM -0.526729603917754 0.281976697277365 no 2408 0.299190687258957 3356 728447
SGTC_2300 7976697 71.57 µM -0.527737560944232 0.281627893797341 no 2409 0.298840749738254 3271 2236109
SGTC_2369 9071472 200 µM -0.528162662408828 0.281480849861381 no 2410 0.298693220898296 3413 17296037
SGTC_277 nystatin 15.5 µM -0.528245688887252 0.281452135065178 no 2411 0.298664410936729 3274 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3043 9092303 49.47 µM -0.530477948177869 0.280680636128233 no 2412 0.29789029717925 3350 25236084
SGTC_1505 k297-0037 20.6 µM -0.533650671044078 0.279585863671872 no 2413 0.296791621947913 3316 4089396
SGTC_247 mechlorethamine 29.705 µM -0.533767113833256 0.279545723659233 no 2414 0.296751334540546 3359 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1827 berberine 7.24 µM -0.535083472956773 0.279092144696665 no 2415 0.296296068850373 3292 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1285 0929-0069 65.5 µM -0.535800022559588 0.278845393104844 no 2416 0.296048383301606 3358 1206237
SGTC_2630 antimycin a 100 µM -0.537215875625379 0.278358141166434 no 2417 0.295559253195686 3351 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1168 k815-0004 80.5 µM -0.537991768337115 0.278091301431912 no 2418 0.295291365789299 3324 642433
SGTC_469 w7 172 µM -0.541372514570392 0.276930076735101 no 2419 0.294125423972827 3423 45115570 A P450 inhibitor.
SGTC_2703 st077852 53.4 µM -0.541883494613786 0.276754771165527 no 2420 0.293949383919152 3427 6281836
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.54375497634765 0.276113173162867 no 2421 0.293305047635245 3518 6710655
SGTC_291 SEC14.278 35.5 µM -0.543830819977373 0.276087187178895 no 2422 0.293278949083459 3449 1068044
SGTC_2206 7254556 146.969 µM -0.545223159932397 0.275610349056336 no 2423 0.292800022353931 3390 4398905
SGTC_797 k781-0471 270 µM -0.546083990504917 0.275315740985187 no 2424 0.292504102031173 3347 23738129
SGTC_1062 mesoridazine 14.2 µM -0.547130355987181 0.274957844826193 no 2425 0.292144589250811 3428 4078 A neuroleptic.
SGTC_100 0086-0128 49.5915 µM -0.551982247039062 0.273301318481405 no 2426 0.29048025822823 3408 93297
SGTC_635 k038-0028 24.7 µM -0.552571026717409 0.273100634914274 no 2427 0.29027859305415 3403 4035102
SGTC_2659 sanguinarine 24.21 µM -0.552847944551194 0.273006273663794 no 2428 0.290183767549444 3360 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2934 9036370 36.88 µM -0.553269836918781 0.27286254263492 no 2429 0.290039326043602 3406 6462800
SGTC_3135 9127742 49.47 µM -0.553501535359837 0.272783623174098 no 2430 0.289960014767854 3393 3643468
SGTC_1913 st060213 96.1 µM -0.553622922590554 0.272742281647226 no 2431 0.289918467507407 3498 688959
SGTC_3236 9132701 49.47 µM -0.553793989358705 0.272684025760948 no 2432 0.289859921149916 3418 24282524
SGTC_285 1486-1325 46 µM -0.557100090479968 0.271559364811332 no 2433 0.288729522869779 3472 22310230
SGTC_2259 7964009 200 µM -0.559096791737986 0.270881252780087 no 2434 0.288047832095908 3478 313134
SGTC_9 0092-0002 10.449 µM -0.559437674678676 0.270765567928499 no 2435 0.287931527720528 3458 759368
SGTC_715 0868-0130 184 µM -0.559648044669857 0.27069418733949 no 2436 0.287859763559397 3510 2876258
SGTC_3273 9137859 49.47 µM -0.560124319807631 0.270532617267792 no 2437 0.287697321578147 3486 2377234
SGTC_3097 9117246 49.47 µM -0.560127390878701 0.270531575603707 no 2438 0.287696274276116 3497 16423892
SGTC_825 1988-2224 89.6 µM -0.560301469375941 0.270472533903491 no 2439 0.287636912667779 3381 1180859
SGTC_3303 9125618 40.5795 µM -0.561337357074481 0.270121328080728 no 2440 0.28728378973533 3411 22695467
SGTC_3193 9111931 49.47 µM -0.561758113641074 0.269978740576485 no 2441 0.287140416972453 3415 17087244
SGTC_2072 5231554 129 µM -0.562616194077001 0.269688067967399 no 2442 0.286848131172342 3516 789545
SGTC_1469 k284-2957 126 µM -0.563676281084489 0.269329182722072 no 2443 0.286487231191472 3433 23884841
SGTC_18 0111-0177 500 nM -0.567538922154371 0.268023541229251 no 2444 0.285174045213273 3511 721752
SGTC_131 0141-0277 33.849 µM -0.568834391131469 0.267586364321164 no 2445 0.284734266606391 3461 1547771
SGTC_1022 4477-0945 21.3 µM -0.571066428259356 0.266833971604256 no 2446 0.283977307259098 3449 4648966
SGTC_3289 9119912 71.43 µM -0.571084805791076 0.266827781200365 no 2447 0.283971078814721 3502 17014829
SGTC_1509 1326-1131 80 µM -0.571163890228243 0.266801142726995 no 2448 0.283944276558729 3453 768313
SGTC_562 3772-2733 112 µM -0.571500133434358 0.266687898967649 no 2449 0.283830334956545 3500 2876874 YIL048W NEO1
SGTC_274 sirtinol 40.1 µM -0.573740253399364 0.26593406692867 no 2450 0.283071792264124 3452 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1002 4049-0206 172 µM -0.574546695769063 0.265662952199463 no 2451 0.282798955543951 3449 4662749
SGTC_39 0986-0283 58.349 µM -0.574676269133104 0.265619404505497 no 2452 0.282755129882361 3544 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_772 k072-0172 35.3 µM -0.574848107829975 0.265561657641983 no 2453 0.282697013830405 3401 5861980
SGTC_917 harmaline 728.087 nM -0.575254426997923 0.265425138310882 no 2454 0.282559619040371 3429 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3109 9122853 49.47 µM -0.576822246695191 0.264898700013699 no 2455 0.282029769796311 3456 1234709
SGTC_658 3253-0951 102 µM -0.576836991886524 0.264893751432958 no 2456 0.28202478888793 3454 1184878
SGTC_1822 st052468 42 µM -0.577339753276406 0.264725049605191 no 2457 0.28185498203219 3401 2873678
SGTC_632 0781-2353 4.65 µM -0.577636855496371 0.264625382500129 no 2458 0.281754659396633 3495 6811515 YHR007C ERG11
SGTC_1325 1431-0015 227 µM -0.577868943076236 0.264547538748583 no 2459 0.281676302259404 3400 1103340
SGTC_2429 5902844 64.44 µM -0.577997160940424 0.264504538602233 no 2460 0.28163301800016 3454 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2729 fluphenazine 10.66 µM -0.578437572767831 0.264356865738565 no 2461 0.281484366586365 3402 3372 An atypical antipsychotic.
SGTC_2332 7982454 138.89 µM -0.580838355847916 0.263552606697628 no 2462 0.280674700868105 3482 2981748
SGTC_181 1447-1644 8.07 µM -0.582163321629325 0.263109280283891 no 2463 0.280228338226953 3463 534600
SGTC_3007 9078383 71.4286 µM -0.582287108661171 0.263067881281123 no 2464 0.28018665365973 3423 6496995
SGTC_900 1112-0045 141 µM -0.582625718927593 0.262954654381741 no 2465 0.280072643961599 3448 56211 YIL048W NEO1
SGTC_2866 9034245 58.44 µM -0.583097911553453 0.262796800871441 no 2466 0.279913694782822 3447 6462273
SGTC_979 1426-2828 121 µM -0.583340678653356 0.262715662947051 no 2467 0.279831991707792 3532 747872
SGTC_212 3807-4682 38.772 µM -0.584048127022366 0.262479291775323 no 2468 0.279593966513775 3516 3125501 YBL034C STU1
SGTC_2387 9077560 195.08 µM -0.58455140110827 0.262311205187299 no 2469 0.279424696817853 3402 5303272
SGTC_190 3970-0790 3.722 µM -0.584778600427227 0.262235341821489 no 2470 0.279348297591251 3479 2832352
SGTC_1167 k781-0610 148 µM -0.585809521609996 0.261891251641378 no 2471 0.279001762217391 3476 4525169
SGTC_2063 5246145 200 µM -0.585965879214509 0.261839084450462 no 2472 0.278949222206694 3507 711240
SGTC_1993 st073995 70.8 µM -0.586511468840114 0.261657095543749 no 2473 0.2787659283464 3458 3098394
SGTC_1986 st071812 45 µM -0.586865760416396 0.261538951498272 no 2474 0.278646933529819 3481 11838594
SGTC_2702 st077768 96.8 µM -0.587124899350526 0.261452554927204 no 2475 0.278559913001423 3449 6484119
SGTC_1925 st057770 10.1 µM -0.587750435743795 0.261244062338845 no 2476 0.278349908396141 3384 5989122
SGTC_1147 3809-1045 12.3 µM -0.587802461984207 0.261226725732757 no 2477 0.278332445662494 3438 325925
SGTC_964 1287-0107 19.4 µM -0.588502578290509 0.260993484812058 no 2478 0.27809750188682 3529 51516812 YPR165W RHO1
SGTC_782 0083-0095 30.5 µM -0.588917660603215 0.260855252394888 no 2479 0.277958255002454 3510 3591729 An indicator and reagent.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.589108980291962 0.260791551008042 no 2480 0.277894084803518 3478 688788
SGTC_2235 salicylic acid 500 µM -0.589407814122434 0.26069206796264 no 2481 0.277793867947022 3479 338 A COX inhibitor and kinase inhibitor.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.590190945427557 0.260431452925941 no 2482 0.277531320931488 3523 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1808 st050063 61.5 µM -0.591070896983106 0.260138777655221 no 2483 0.277236459400787 3521 4011993
SGTC_1868 st057644 42.7 µM -0.591669720879796 0.259939703517139 no 2484 0.277035888140738 3438 688665
SGTC_1778 st046819 58.9 µM -0.592111478314386 0.259792895227721 no 2485 0.276887970570392 3460 671715
SGTC_2413 inermin 26.06 µM -0.592726537376067 0.259588565259503 no 2486 0.276682089306326 3582 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1231 0242-0792 125 µM -0.592975251555736 0.259505963004234 no 2487 0.276598857485386 3476 3707635
SGTC_1923 st058458 19.1 µM -0.593427806106654 0.259355696684938 no 2488 0.276447442283495 3568 3534982
SGTC_3320 9137005 35.139 µM -0.593769914302015 0.259242132843583 no 2489 0.276333007085323 3457 4908713
SGTC_1296 1068-0102 11.9 µM -0.594350487953228 0.259049468510037 no 2490 0.276138858384413 3475 767053
SGTC_2321 7390090 138.78 µM -0.594891466187438 0.258870010645668 no 2491 0.275958011008011 3426 649046
SGTC_1241 0364-0022 50.8 µM -0.595177191055723 0.258775253545946 no 2492 0.275862517536188 3448 4563895
SGTC_147 4466-0538 29.23 µM -0.595318064736344 0.258728541149293 no 2493 0.27581544144737 3594 6742687 YHR072W ERG7
SGTC_1735 st034310 56.75 µM -0.595859482488958 0.258549052709131 no 2494 0.275634551353231 3542 871153
SGTC_2180 6301957 200 µM -0.596208452642458 0.258433397839085 no 2495 0.27551798978492 3500 845462
SGTC_2799 7812892 81.82 µM -0.596371123010241 0.25837949516707 no 2496 0.275463663586818 3530 20205235
SGTC_161 4065-0411 162.148 µM -0.596747106288916 0.258254931137003 no 2497 0.275338118525914 3475 1906281 YLR208W SEC13
SGTC_1470 k295-0292 231 µM -0.597014287475788 0.258166432384777 no 2498 0.275248920829661 3529 5045612
SGTC_2080 5212524 12.4 µM -0.597187332603423 0.258109122825329 no 2499 0.275191157785825 3506 260183
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.599235675650446 0.25743124850159 no 2500 0.274507867812171 3499 688662
SGTC_1852 st056254 31.4 µM -0.602591818397698 0.256322576351768 no 2501 0.273390132244723 3448 442583
SGTC_971 1315-0384 26.7 µM -0.602865931851921 0.256232135447424 no 2502 0.273298940670624 3497 6769120
SGTC_2680 butyl paraben 22.24 µM -0.60289241884359 0.256223397219518 no 2503 0.273290129823865 3538 7184 An antifungal and steroid mimetic.
SGTC_314 1671-0008 2.74 µM -0.603347058723615 0.256073432840425 no 2504 0.273138916680836 3463 3913060
SGTC_773 4358-1457 44.6 µM -0.604304057350497 0.255757913538446 no 2505 0.272820754661781 3551 1186886
SGTC_2148 5546263 113.568 µM -0.604883562988611 0.25556695114309 no 2506 0.272628182680556 3478 792097
SGTC_1495 4469-0029 237 µM -0.606552079743546 0.255017547061416 no 2507 0.27207410511119 3524 793680
SGTC_91 0417-1751 58.384 µM -0.607212095177151 0.25480038988368 no 2508 0.271855083207802 3589 6795624
SGTC_2721 ifenprodil 61.44 µM -0.608735514827603 0.254299526716648 no 2509 0.271349881288792 3549 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1943 st076331 65.2 µM -0.608818153060874 0.254272372050413 no 2510 0.271322489883305 3578 24208415
SGTC_2848 9016370 25.97 µM -0.610179446238253 0.253825274225999 no 2511 0.270871471807747 3555 7894410
SGTC_3285 9112818 20.8695 µM -0.610587206042899 0.253691431552654 no 2512 0.270736447361282 3554 17017947 YPR165W RHO1
SGTC_1348 1493-0373 93.8 µM -0.610758880716725 0.253635092317106 no 2513 0.270679609541941 3500 3010129
SGTC_1637 st007924 17.4 µM -0.611642968728915 0.253345061344884 no 2514 0.270387001263702 3543 683336
SGTC_1386 3228-0095 33.8 µM -0.612281281427907 0.253135767030922 no 2515 0.270175836030661 3528 870181
SGTC_2254 7938975 95.19 µM -0.615614783800174 0.252044234914611 no 2516 0.269074395826836 3605 2969277
SGTC_1896 st058441 89 µM -0.61688417642259 0.251629234961117 no 2517 0.268655562300439 3476 688759
SGTC_3256 9138902 49.47 µM -0.617030209130769 0.251581515944722 no 2518 0.268607400123479 3540 17228773
SGTC_1361 1608-0041 5.61 µM -0.61754204090584 0.251414302746228 no 2519 0.268438630200193 3537 X1361
SGTC_2929 9013348 24.6 µM -0.619361017856441 0.250820526589884 no 2520 0.267839277798662 3532 2995952
SGTC_582 0987-0078 156 µM -0.620764886634066 0.250362764030381 no 2521 0.26737716477512 3611 1625765
SGTC_2059 5238311 157 µM -0.621064030123892 0.250265278928831 no 2522 0.267278747392652 3523 703021
SGTC_52 0329-0193 875 nM -0.621097664642225 0.250254319345998 no 2523 0.267267682872257 3616 3739292
SGTC_867 0518-0118 155 µM -0.621918430157559 0.24998695728877 no 2524 0.266997752840675 3586 6848158
SGTC_3049 9092223 49.47 µM -0.622462865005669 0.24980969282276 no 2525 0.266818777302377 3518 8623917
SGTC_1430 4049-0248 69.1 µM -0.622495663149872 0.249799016090723 no 2526 0.266807997295707 3593 22774488
SGTC_319 1348-1596 45.5 µM -0.623311734490913 0.24953343960491 no 2527 0.266539844025793 3601 5380505
SGTC_1329 1447-1697 50.6 µM -0.624792357753234 0.24905197931047 no 2528 0.2660536735507 3547 2840515
SGTC_1417 3966-0327 90.4 µM -0.625194841092833 0.24892118765111 no 2529 0.265921593700332 3579 651118
SGTC_904 1141-0088 396 µM -0.625269883274166 0.24889680586232 no 2530 0.265896971362164 3524 1378119
SGTC_400 oxethazaine 37.5 µM -0.626829327459638 0.248390418115232 no 2531 0.265385558559858 3526 4621 A local anesthetic.
SGTC_3288 9119690 36.221 µM -0.627511862720628 0.248168955956854 no 2532 0.265161881309208 3513 17595618 YKL019W RAM2
SGTC_3122 9126309 49.47 µM -0.629050335904882 0.247670154154182 no 2533 0.26465805146416 3593 17591206
SGTC_2691 st077356 60.2 µM -0.630793591721215 0.247105605716442 no 2534 0.264087747007481 3598 2839272
SGTC_1202 1988-0068 29.6 µM -0.632032241415096 0.246704891228798 no 2535 0.263682904791325 3477 2850480
SGTC_681 1642-0006 26.6 µM -0.632485899154296 0.246558215915058 no 2536 0.263534709827354 3580 4446530
SGTC_115 0527-0192 112.043 µM -0.633165923067116 0.246338440068073 no 2537 0.263312648164963 3574 4233931
SGTC_1802 st050112 57.9 µM -0.633856935673237 0.246115220416172 no 2538 0.263087096069061 3561 4662563
SGTC_2463 5473429 200 µM -0.633882599466624 0.246106932262242 no 2539 0.263078721101482 3508 5399405
SGTC_1981 st071826 47 µM -0.634315776710852 0.245967059725294 no 2540 0.262937381211592 3533 11838600
SGTC_2216 7189485 200 µM -0.63443134473404 0.2459297501254 no 2541 0.262899679486148 3578 731273
SGTC_2353 9059630 146.67 µM -0.635444488646165 0.245602800135231 no 2542 0.262569280186585 3568 4779114
SGTC_1382 3002-2117 298 µM -0.636220872660667 0.245352412625945 no 2543 0.262316235243206 3625 1497314
SGTC_2726 cimetidine 79.27 µM -0.636776795804951 0.245173209114914 no 2544 0.262135121340305 3564 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1280 0880-0253 10.1 µM -0.638977465887376 0.244464507752793 no 2545 0.26141879567313 3544 6836607
SGTC_2610 ononetin 44.17 µM -0.639161259648706 0.244405368993089 no 2546 0.261359015688044 3567 259632
SGTC_630 4356-0227 183 µM -0.639205598559388 0.244391103350928 no 2547 0.261344595251928 3591 779312
SGTC_184 1494-0393 24.714 µM -0.641392621679667 0.243688005745477 no 2548 0.260633812758698 3574 3090647
SGTC_919 tnp00227 403.569 nM -0.644353472030236 0.242737876171489 no 2549 0.259673124309567 3598 1269246 A methoxyflavone. YNL221C POP1
SGTC_1927 st060202 13.8 µM -0.644512302030239 0.242686964747096 no 2550 0.259621641444194 3587 688887
SGTC_1955 wogonin 32.4 µM -0.644708520309016 0.242624076853602 no 2551 0.259558046887409 3657 5281703 A flavanone.
SGTC_85 0868-0259 160.055 µM -0.645387308232901 0.242406593624881 no 2552 0.259338113043297 3510 83173
SGTC_1423 4048-0112 5.59 µM -0.645684229506664 0.242311493448956 no 2553 0.259241937963113 3590 X1423
SGTC_1000 4048-0884 8.67 µM -0.646111013072998 0.242174835426796 no 2554 0.259103731785883 3587 13040088
SGTC_1682 st012968 530 nM -0.646312909158419 0.242110201950923 no 2555 0.259038364648028 3517 24207270
SGTC_1224 0823-0416 294 µM -0.646492457046232 0.242052730715257 no 2556 0.258980240267372 3614 3598164
SGTC_1915 st067105 30.6 µM -0.647227756812266 0.241817446834304 no 2557 0.25874227476486 3597 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_619 1652-1634 108 µM -0.647308973896323 0.241791466310833 no 2558 0.258715997373692 3540 5400454
SGTC_1429 4049-0205 9.46 µM -0.648319959175603 0.241468189170437 no 2559 0.258389013678154 3627 22774478
SGTC_930 2810-3379 265 µM -0.648354495618438 0.24145714979255 no 2560 0.258377847315027 3643 1015764
SGTC_1214 0358-0031 63.7 µM -0.648671227667131 0.24135592097758 no 2561 0.25827545280044 3639 4301366
SGTC_2171 5739187 198.077 µM -0.648693223284779 0.241348891947548 no 2562 0.258268342742537 3527 2262761
SGTC_1136 pergolide 1.05886 µM -0.648959422566274 0.241263832787204 no 2563 0.25818230217735 3576 47811 A dopamine receptor agonist.
SGTC_2889 9059656 51.95 µM -0.64928319219045 0.241160400027125 no 2564 0.258077673837038 3639 3949838
SGTC_2326 6164455 177.58 µM -0.649708880884328 0.241024444475477 no 2565 0.257940143128736 3575 2888790
SGTC_1439 4092-1168 46 µM -0.649935899012733 0.240951956951564 no 2566 0.25786681408427 3583 2886240
SGTC_901 1112-0062 60.1 µM -0.650180147856607 0.24087398085514 no 2567 0.257787931434197 3597 1908457
SGTC_2676 harmalol 100 µM -0.650669720696395 0.240717726764602 no 2568 0.257629856621533 3608 5459187 A monoamine oxidase inhibitor
SGTC_1073 triclabendazole 3.09 µM -0.652243953255345 0.240215662287575 no 2569 0.257121904816809 3631 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2687 chenodiol 100 µM -0.652790106774728 0.240041612886074 no 2570 0.256945801239445 3610 5702181 A cholesterol synthesis inhibitor.
SGTC_2832 7992762 51.95 µM -0.653665270253415 0.239762857290121 no 2571 0.256663741485005 3478 2985177
SGTC_957 1187-1561 14.1 µM -0.654457325379737 0.239510725566237 no 2572 0.256408606092687 3585 1538454
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.655614906160809 0.239142498065209 no 2573 0.256035966075884 3556 4620898
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.655838765825843 0.23907132382055 no 2574 0.255963935407074 3598 6708561
SGTC_1334 1486-0610 236 µM -0.65974673670126 0.237830685644486 no 2575 0.254708184487946 3608 3742339
SGTC_1051 3253-3903 78 µM -0.659805685193859 0.237811998719124 no 2576 0.254689267256976 3594 5509239
SGTC_2653 dihydrofissinolide 100 µM -0.659902958200332 0.237781164519077 no 2577 0.254658052869406 3637 6857746
SGTC_1293 1000-1278 195 µM -0.660468512290224 0.237601935125277 no 2578 0.254476609281053 3654 678847
SGTC_3039 9090270 49.47 µM -0.660601091138497 0.23755993037401 no 2579 0.254434084546165 3597 17173750
SGTC_3047 9092122 49.47 µM -0.661228858137255 0.237361091273362 no 2580 0.254232778527288 3577 17173831
SGTC_89 0302-0250 142.109 µM -0.661703948993993 0.237210671629106 no 2581 0.254080486695959 3670 4203518 YLR208W SEC13
SGTC_2325 6158266 200 µM -0.662663083164386 0.236907157508855 no 2582 0.253773179184437 3615 3623240
SGTC_2755 lomerizine 42.69 µM -0.662916285336573 0.236827068342345 no 2583 0.253692085535083 3623 3949 A calcium channel blocker.
SGTC_674 0498-0004 451 µM -0.666440463344536 0.23571389952498 no 2584 0.252564803195177 3586 4231473
SGTC_2118 5526350 200 µM -0.668407382137735 0.23509387312817 no 2585 0.251936792269419 3619 743594
SGTC_3233 9132340 49.47 µM -0.670121348799391 0.234554319489833 no 2586 0.251390218298634 3590 17682950
SGTC_2887 9044784 58.44 µM -0.670224777170043 0.234521782351978 no 2587 0.251357255658549 3637 6465546
SGTC_258 haloperidol 50.781 µM -0.671281200257979 0.234189589261854 no 2588 0.25102070432436 3605 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2784 7567673 72.73 µM -0.671650978568602 0.234073373758059 no 2589 0.250902958087384 3656 3471247
SGTC_1677 st019204 53.9 µM -0.671686883574746 0.234062091081146 no 2590 0.250891526634022 3590 3945625
SGTC_826 1683-5028 118 µM -0.672877621235542 0.233688088076368 no 2591 0.250512575221374 3651 722377
SGTC_3207 9114163 49.47 µM -0.67362066350266 0.233454871278612 no 2592 0.250276256317474 3680 849233
SGTC_1482 3346-2049 8.48 µM -0.674268490188463 0.233251644950186 no 2593 0.250070316493121 3621 3826804
SGTC_1903 st060211 78.3 µM -0.676158256448165 0.232659377574041 no 2594 0.249470086283476 3663 688960
SGTC_2722 naftopidil 47.16 µM -0.677150778004894 0.232348648757656 no 2595 0.249155147113606 3604 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_114 0364-0001 490.298 µM -0.677682153018893 0.232182386063383 no 2596 0.248986622310302 3633 4003655
SGTC_3074 9116018 49.47 µM -0.678196973330955 0.23202136636384 no 2597 0.24882340567549 3683 17027303
SGTC_1624 st003710 6.25 µM -0.679435598674465 0.231634217931276 no 2598 0.24843095019434 3654 24207033
SGTC_1922 5578187 25 µM -0.679805847383201 0.23151856182185 no 2599 0.24831370185243 3672 1350412
SGTC_2598 perillyl alcohol 100 µM -0.68004541761036 0.231443743444191 no 2600 0.248237851782287 3646 10819 An apoptosis inducer.
SGTC_2495 cafestol 54.53 µM -0.680307908020601 0.231361782516727 no 2601 0.248154759164063 3652 16667697 An anti-infammatory.
SGTC_76 0433-0009 400.328 µM -0.681039288270196 0.231133499187446 no 2602 0.24792331545582 3644 2841569
SGTC_949 1165-0505 146 µM -0.682505234324332 0.23067631690753 no 2603 0.247459767059489 3676 6244267
SGTC_1743 st037606 46.3785 µM -0.682561410044663 0.230658807531212 no 2604 0.247442012892652 3668 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2849 9019321 12.99 µM -0.685865443007394 0.229630282619713 no 2605 0.246398981733019 3632 16489627
SGTC_2402 5553605 200 µM -0.686410135393094 0.229460970287534 no 2606 0.246227257458955 3682 6758546
SGTC_622 1348-1566 26.3 µM -0.686927083997793 0.229300346566864 no 2607 0.246064339292237 3688 7340407
SGTC_1964 st076914 61 µM -0.688240533206238 0.228892521790091 no 2608 0.245650661404731 3677 24208661
SGTC_2307 7538926 6.34 µM -0.689689849849619 0.22844298309791 no 2609 0.245194625134127 3665 96582
SGTC_2360 9040895 200 µM -0.690351323862124 0.228237976790551 no 2610 0.244986639720765 3629 4914414
SGTC_3147 9097027 49.47 µM -0.690367572439996 0.228232942277019 no 2611 0.244981531920819 3682 25236841
SGTC_688 0527-0193 473 µM -0.691010550589473 0.228033769904024 no 2612 0.244779455386291 3684 4007154
SGTC_2191 5911152 200 µM -0.691382912038328 0.227918469931631 no 2613 0.244662469883151 3659 2875902
SGTC_811 0416-0114 265 µM -0.692684443231676 0.22751571470167 no 2614 0.244253801995356 3675 6612453
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.694216973140997 0.227041991811754 no 2615 0.243773074939329 3682 5379071
SGTC_1290 0986-0249 10.2 µM -0.69492016270675 0.226824813982861 no 2616 0.243552668076164 3618 53329
SGTC_2673 kobusone 100 µM -0.695136288950224 0.226758087643258 no 2617 0.243484947365868 3722 6710676 An epoxy ketone and protein crosslinker.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.695678673717986 0.22659068175081 no 2618 0.243315042047501 3685 5106787 A p450 inhibitor.
SGTC_2068 5226020 147 µM -0.696180104155563 0.226435978404495 no 2619 0.243158022941336 3704 1810509
SGTC_2034 5197015 53.07 µM -0.698904273878736 0.225596549554145 no 2620 0.242305928193326 3669 780676
SGTC_2024 5144227 134 µM -0.702266439016051 0.224562960146258 no 2621 0.241256509423152 3701 3475211
SGTC_1076 itraconazole 331 nM -0.702793732127375 0.224401104924179 no 2622 0.241092151947909 3693 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_294 k038-0071 157 µM -0.703817968157737 0.224086899915718 no 2623 0.240773071211574 3685 24152826
SGTC_43 0570-0105 72.5 µM -0.705355686115765 0.223615643546533 no 2624 0.240294456999731 3715 1114046 YDL195W SEC31
SGTC_1132 3456-3614 2.5 µM -0.706413883625003 0.223291670934002 no 2625 0.239965394712636 3750 3125502
SGTC_2619 obliquin 87.91 µM -0.706556748956133 0.223247952454099 no 2626 0.239920987444113 3664 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1204 4049-0315 18.3 µM -0.706608690053587 0.223232059072118 no 2627 0.239904843544712 3730 588402
SGTC_2117 5521686 200 µM -0.707730167099795 0.222889057031353 no 2628 0.239556419928674 3671 803312
SGTC_172 1112-0046 2.638 µM -0.707846900733376 0.222853371488933 no 2629 0.239520168678604 3635 2802135 YIL048W NEO1
SGTC_3152 9099253 49.47 µM -0.709209564927814 0.222437045078397 no 2630 0.239097219372193 3681 25236131
SGTC_566 0958-0068 16.5 µM -0.709621243151087 0.222311354867231 no 2631 0.238969521335536 3659 6815365
SGTC_994 3910-0338 138 µM -0.709728194793401 0.222278707902837 no 2632 0.238936352221112 3768 3479481
SGTC_464 bw-b 70c 158 µM -0.710229037233886 0.222125862264898 no 2633 0.23878105851445 3712 5353454
SGTC_3302 9125395 16.351 µM -0.710587537986688 0.222016492896482 no 2634 0.238669933896424 3657 17599668
SGTC_2394 5221648 200 µM -0.712505305935799 0.221431953560874 no 2635 0.23807596348952 3766 788586
SGTC_1303 1160-0052 261 µM -0.713403055149089 0.221158620536433 no 2636 0.237798191561186 3697 3562476
SGTC_2084 5306078 60.6385 µM -0.714096204737331 0.220947713016311 no 2637 0.23758384631354 3641 679340
SGTC_515 4092-1064 102 µM -0.714617947587422 0.22078903611503 no 2638 0.237422575780013 3726 717353
SGTC_3281 9140613 49.47 µM -0.715240993741315 0.220599635505456 no 2639 0.23723007119259 3640 16013766
SGTC_3120 9124077 49.47 µM -0.716549885801609 0.220202047033633 no 2640 0.236825937965148 3756 18774327 YGL155W CDC43
SGTC_530 4358-1714 28 µM -0.717704236319031 0.219851743302138 no 2641 0.236469835336798 3765 1564641
SGTC_225 nsc-122657 1.016 µM -0.718166971786954 0.219711409639562 no 2642 0.236327170048712 3666 275685
SGTC_2911 7942208 15.64 µM -0.718325465431883 0.219663355141101 no 2643 0.236278316005233 3698 1243384
SGTC_1320 1313-0481 95.3 µM -0.71965083783597 0.219261745026195 no 2644 0.235870001301824 3718 6813365 YLR208W SEC13
SGTC_2477 5967686 25.23 µM -0.721695573850219 0.218642984197602 no 2645 0.235240831975313 3727 776118
SGTC_421 streptovitacin 30 mM -0.723469187927297 0.218107083024139 no 2646 0.234695838757147 3778 91467 include heat shock
SGTC_1997 st073024 93.8 µM -0.723803710562951 0.218006091246967 no 2647 0.234593125503915 3699 686268
SGTC_2699 st077704 54.6 µM -0.723978386003814 0.2179533677641 no 2648 0.234539502295368 3733 645852
SGTC_1645 Cervolide 78 µM -0.726402346233307 0.217222486556304 no 2649 0.23379607664808 3676 23173 A fragrance.
SGTC_1350 1495-0454 146 µM -0.727063260438895 0.217023451227691 no 2650 0.233593601893296 3722 1069057
SGTC_2991 9074669 71.4286 µM -0.730842853730944 0.215887247457279 no 2651 0.232437572360543 3696 17333109
SGTC_382 3229-0966 23.2 µM -0.732432672486021 0.215410355328538 no 2652 0.231952261416206 3735 5722370
SGTC_637 1181-0519 7.26 µM -0.732758736976681 0.215312622532825 no 2653 0.231852796158207 3741 6252091 YGR060W ERG25
SGTC_1521 st012942 49.4 µM -0.733450940993856 0.215105230380908 no 2654 0.231641719613299 3775 24207259
SGTC_273 hydroxyurea 18.1 mM -0.733654545337646 0.215044250297234 no 2655 0.231579654113742 3778 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_394 menadione 8.33 µM -0.734848821657502 0.214686763296309 no 2656 0.231215784949951 3690 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2618 avocadyne 43.43 µM -0.735479289618048 0.214498182434675 no 2657 0.231023824242383 3668 3015189
SGTC_1757 st041620 31.8375 µM -0.737262218887965 0.213965407533921 no 2658 0.230481451538729 3780 5289815
SGTC_613 3914-0030 117 µM -0.737552321218353 0.213878792087596 no 2659 0.230393268869617 3501 1145395
SGTC_886 0866-0150 153 µM -0.740031320350174 0.213139473837083 no 2660 0.229640495016302 3752 271463
SGTC_1302 1159-0335 255 µM -0.740115748148195 0.213114320994865 no 2661 0.229614881920988 3758 649284
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.743211183339962 0.21219332091462 no 2662 0.22867691683606 3727 641818 YHR062C RPP1
SGTC_2001 4023502 57.655 µM -0.744835111455115 0.211711077577452 no 2663 0.228185703045598 3770 108941 YCR052W RSC6
SGTC_1077 5-fluorocytosine 377 nM -0.744971281811495 0.211670669458696 no 2664 0.228144540539224 3775 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_743 1275-0778 158 µM -0.746340087103194 0.211264731679723 no 2665 0.227731000714651 3759 2849257 YMR203W TOM40
SGTC_2006 4011487 200 µM -0.746557525687487 0.211200289324352 no 2666 0.22766534760313 3800 45595294
SGTC_1322 1348-1070 12 µM -0.751349287194103 0.209783079286362 no 2667 0.226221237141195 3721 6758089
SGTC_522 1273-0010 11.6 µM -0.75184659829942 0.209636315612412 no 2668 0.22607165771581 3815 5705015
SGTC_905 2-aminofluorene 215 µM -0.752390507723626 0.209475869259422 no 2669 0.225908126640404 3781 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2381 9035592 200 µM -0.755331438696335 0.208609584306628 no 2670 0.225025069778013 3776 4749657
SGTC_2657 nystatin 74.44 µM -0.755817231413427 0.208466692004458 no 2671 0.224879391997557 3790 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1160 4092-0570 10.5 µM -0.757092913292646 0.208091734603383 no 2672 0.224497099727314 3746 4994975
SGTC_2589 lobaric acid 100 µM -0.757122760704177 0.208082966410325 no 2673 0.22448815956765 3781 73157 A novel microtubule depolymerizer.
SGTC_834 0312-0008 75.7 µM -0.757377685731664 0.208008086662497 no 2674 0.224411810409346 3758 6385573 YIL048W NEO1
SGTC_2962 9082311 13.18 µM -0.758667470039212 0.207629479093516 no 2675 0.224025750484573 3763 16459453
SGTC_2450 5739737 12.93 µM -0.759332895221573 0.207434307304379 no 2676 0.223826722183974 3789 2262825
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.76001826507893 0.207233399081501 no 2677 0.223621833547407 3825 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1929 genistein trimethyl ether 50.5 µM -0.762394772238175 0.206537645477291 no 2678 0.222912212710852 3744 136420
SGTC_2528 xanthyletin 44.79 µM -0.765301601075881 0.205688517231518 no 2679 0.222045985438373 3834 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2964 9083345 53.42 µM -0.766752160535654 0.205265563170336 no 2680 0.221614442318877 3767 17741579
SGTC_1933 st074711 15.9 µM -0.767708529313465 0.20498698805023 no 2681 0.22133018387456 3773 17250958
SGTC_423 5-fluorouracil 457 µM -0.767726022118988 0.204981894766167 no 2682 0.221324986486296 3752 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1460 k062-0059 9.15 µM -0.768051595072458 0.20488711320926 no 2683 0.221228266369127 3682 1373085
SGTC_139 0099-0334 718.624 µM -0.768460743358598 0.204768037965914 no 2684 0.221106752264767 3828 97690
SGTC_3339 9145883 14.936 µM -0.768750180122186 0.20468382746905 no 2685 0.221020814692619 3698 2030670
SGTC_235 0330-0087 5 mM -0.768825727132548 0.204661850752088 no 2686 0.220998386940539 3823 46494818 YHR062C RPP1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.76931928557498 0.204518308548848 no 2687 0.220851895576398 3793 75037 A free radical scavenger.
SGTC_2666 tannic acid 100 µM -0.77166737726299 0.203836231145514 no 2688 0.220155728547104 3791 16134267 A thiamine antagonist.
SGTC_2838 9002687 71.43 µM -0.773149076431264 0.20340652340114 no 2689 0.2197170797921 3785 6457060
SGTC_3338 9144300 39.5675 µM -0.773618322898792 0.203270549943897 no 2690 0.219578266690273 3823 4901274
SGTC_1965 Pectolinarigenin 58.4 µM -0.773876508838928 0.203195758594997 no 2691 0.219501911274898 3786 5320438 An anti-inflammatory.
SGTC_794 k038-0031 316 µM -0.773990647112635 0.203162700236219 no 2692 0.219468161102828 3798 6624242
SGTC_3294 9122953 26.2835 µM -0.774251400257323 0.203087189228833 no 2693 0.219391068761607 3787 16459826
SGTC_1953 st076800 12.1 µM -0.777945692027763 0.202019167810746 no 2694 0.218300514975783 3840 297591
SGTC_705 1124-0212 310 µM -0.779142196039472 0.201673979948022 no 2695 0.217947978051284 3752 9554485
SGTC_2942 9052777 62.25 µM -0.779189734906828 0.201660272426705 no 2696 0.217933978023664 3885 6469503
SGTC_109 0132-0036 33.701 µM -0.779809230511311 0.201481695948745 no 2697 0.217751586182802 3633 67274 A color developer.
SGTC_3000 9075062 71.4286 µM -0.780706178446411 0.201223308748218 no 2698 0.217487662962675 3786 17057871
SGTC_2122 5258151 111.688 µM -0.78217220186255 0.200801413811225 no 2699 0.217056689428281 3809 2173356
SGTC_2028 5153890 36.43 µM -0.782392605064253 0.200738031706547 no 2700 0.216991939202302 3768 2830968 YPR165W RHO1
SGTC_1765 st044815 90.4 µM -0.782507223384238 0.200705075269952 no 2701 0.216958270954746 3848 645695
SGTC_2188 6126565 140.678 µM -0.782614002421818 0.200674375800546 no 2702 0.216926908152773 3742 874518
SGTC_3331 9141060 1.957 µM -0.784341151600853 0.200178204050004 no 2703 0.216419979475948 3791 4906567 YPR165W RHO1
SGTC_2058 5236698 133 µM -0.787076010348582 0.199394049371886 no 2704 0.215618685871096 3816 766665
SGTC_1597 7-benzyloxygramine 47.5 µM -0.787856611521167 0.199170570559486 no 2705 0.21539029141182 3781 260807
SGTC_814 3342-0569 96 µM -0.788216654340251 0.199067544532405 no 2706 0.215284994555561 3849 4346283
SGTC_2319 6033012 152.6 µM -0.78846505443043 0.198996483723853 no 2707 0.215212365756273 3787 847246
SGTC_1914 st062367 72.6 µM -0.789239268959273 0.198775099160749 no 2708 0.214986087244147 3833 978205
SGTC_3113 9123498 49.47 µM -0.790759839345183 0.198340728577258 no 2709 0.21454207480411 3858 8897275
SGTC_844 0330-0132 15.3 µM -0.791160430593376 0.198226389913779 no 2710 0.214425189391793 3846 2828079
SGTC_3200 9114385 49.47 µM -0.792621687489967 0.197809648400377 no 2711 0.213999134606767 3846 17018030 YLR208W SEC13
SGTC_3283 9109332 35.8195 µM -0.792804180703886 0.197757639663162 no 2712 0.213945960181289 3687 17027281
SGTC_1175 0741-0056 27.6 µM -0.793932388249374 0.197436295301139 no 2713 0.21361739664286 3897 765927
SGTC_3270 9137563 49.47 µM -0.794147365579914 0.197375099713215 no 2714 0.213554822985147 3812 17015724
SGTC_15 0266-0086 27.098 µM -0.795012185848213 0.197129035326394 no 2715 0.213303206851151 3896 1712902 YIL048W NEO1
SGTC_1034 k072-0165 12.7 µM -0.795777275948711 0.196911501654243 no 2716 0.213080750996873 3824 5835461
SGTC_2734 clemastine 41.6 µM -0.796922687652789 0.196586105102516 no 2717 0.212747966801391 3829 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2266 7929956 200 µM -0.797074798495934 0.196542916909961 no 2718 0.212703795846032 3787 2967153
SGTC_2214 7179297 48.276 µM -0.797627858412049 0.196385937388584 no 2719 0.21254323977485 3840 769744
SGTC_3239 9133757 49.47 µM -0.798615683569192 0.196105744046266 no 2720 0.212256645371632 3830 17036923
SGTC_2322 7413319 38.22 µM -0.798682445903921 0.196086815881559 no 2721 0.212237283991394 3895 1840400
SGTC_2357 9067248 200 µM -0.800491936076381 0.19557421926085 no 2722 0.211712916901908 3847 9150235
SGTC_2343 7990716 14.84 µM -0.801542868391974 0.195276882554129 no 2723 0.211408718544604 3828 6456862
SGTC_269 exalamide 29 µM -0.801950233600217 0.195161702008485 no 2724 0.211290873238527 3784 3316 A derivative of salicylamide.
SGTC_2558 carylophyllene oxide 100 µM -0.803101598369718 0.194836382516636 no 2725 0.210958006975085 3928 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1638 st008370 60.6 µM -0.803427342646326 0.194744402971557 no 2726 0.210863888232281 3812 24207134
SGTC_2517 totarol 10 µM -0.803513282402255 0.194720140795669 no 2727 0.210839061382166 3845 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_479 n-linoleoylglycine 10 µM -0.803949199515716 0.194597102702655 no 2728 0.210713157140821 3865 6433346 An anti-infammatory.
SGTC_1512 0259-0544 12.2 µM -0.804654321344672 0.194398181459487 no 2729 0.21050959294912 3791 18476
SGTC_2566 crystal violet carbinol 226 nM -0.806565339264178 0.193859688736456 no 2730 0.209958474842773 3870 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1242 0402-0103 60.1 µM -0.807878085973856 0.193490306105975 no 2731 0.209580383829989 3789 432868
SGTC_1864 st057645 30.4 µM -0.807933601129231 0.193474694636571 no 2732 0.209564403451999 3874 688666
SGTC_2992 9074591 71.4286 µM -0.80835844313307 0.193355249856049 no 2733 0.209442133806872 3815 17741321
SGTC_1801 st050089 28.441 µM -0.808707783792746 0.193257066078126 no 2734 0.209341624923476 3870 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3174 9107204 49.47 µM -0.812291812638315 0.192251516876557 no 2735 0.208312103697297 3878 3938802
SGTC_3019 9081971 49.47 µM -0.813142085326882 0.192013431533495 no 2736 0.208068299814006 3856 16451803
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.814013335086865 0.191769659651947 no 2737 0.207818655840367 3864 165521
SGTC_835 0312-0010 67.2 µM -0.814272783267776 0.191697103816219 no 2738 0.207744348926565 3812 1626196
SGTC_736 0958-0254 92.6 µM -0.814945562511224 0.191509036447126 no 2739 0.207551735604734 3942 6812352
SGTC_1378 2093-0007 380 nM -0.815897911703432 0.191243011987933 no 2740 0.207279263316185 3929 3618014
SGTC_2153 5569715 200 µM -0.816208938104344 0.191156180524064 no 2741 0.207190322810721 3864 2054701
SGTC_1916 st067606 49.2 µM -0.816727357494393 0.19101150341074 no 2742 0.207042126785392 3862 19590279
SGTC_931 2812-0076 566 µM -0.822748852068217 0.189335987955199 no 2743 0.205325414177398 3872 3450959
SGTC_1488 4013-0813 75.9 µM -0.823819077651316 0.189039141212078 no 2744 0.205021182977424 3828 2910057
SGTC_3201 9113999 49.47 µM -0.825305305804554 0.188627384278046 no 2745 0.204599140155784 3913 16649224
SGTC_2288 7946289 167.31 µM -0.82774064024916 0.187953875494193 no 2746 0.203908699067993 3899 1246052
SGTC_777 1315-0167 517 µM -0.831338057227936 0.186961705097694 no 2747 0.202891340514288 3929 4221767
SGTC_2947 9072639 7.68 µM -0.831753201611871 0.186847416876588 no 2748 0.202774132088085 3917 16488146
SGTC_843 0310-0051 143 µM -0.83228414123859 0.186701313534752 no 2749 0.202624289962185 3904 2065037
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.832853581742137 0.186544694193151 no 2750 0.202463655668397 3820 5355888
SGTC_540 1187-0821 17.3 µM -0.833227516522556 0.18644189116153 no 2751 0.202358213294462 3835 847520
SGTC_1825 st052143 62.6 µM -0.833246615250242 0.186436641436372 no 2752 0.202352828704397 3877 674173
SGTC_3082 9117008 49.47 µM -0.833713626688083 0.186308301081066 no 2753 0.202221188739485 3944 41448529
SGTC_853 0419-0306 21 µM -0.834146442475267 0.186189406987379 no 2754 0.20209923350867 3889 762713
SGTC_1020 4335-0961 93.3 µM -0.835118863217549 0.185922455464166 no 2755 0.201825393453559 3821 669075
SGTC_2731 amoxapine 43.43 µM -0.836139592980168 0.185642497477385 no 2756 0.201538188393881 3955 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1655 st012546 55.1 µM -0.836429272844627 0.185563093962562 no 2757 0.201456725140734 3852 720985 YLR208W SEC13
SGTC_1441 4106-0040 13 µM -0.839179795947922 0.184810204582337 no 2758 0.200684211593217 3857 2904180
SGTC_1489 4065-0444 182 µM -0.839534944796724 0.184713129745474 no 2759 0.200584594072331 3835 2877968
SGTC_572 0960-0087 17.7 µM -0.839899499325602 0.184613516978521 no 2760 0.200482369191752 3894 6796365
SGTC_2423 st077119 87.2 µM -0.841048504298644 0.184299775526976 no 2761 0.200160381029148 3818 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3212 9128307 49.47 µM -0.84111756597653 0.18428092847257 no 2762 0.200141037632195 3856 27243542
SGTC_1294 1000-1494 117 µM -0.841166874336369 0.184267472867561 no 2763 0.200127227604306 3875 712797 YDL207W GLE1
SGTC_668 1682-0499 62.6 µM -0.84316360238735 0.183723105706138 no 2764 0.199568475775191 3911 682214
SGTC_824 1304-0008 100 µM -0.843345688651592 0.183673513499743 no 2765 0.199517568653865 3919 768245
SGTC_3259 9138485 49.47 µM -0.847092469319053 0.182654909185999 no 2766 0.19847179114479 3944 17646153
SGTC_1251 0490-5699 265 µM -0.847355111971914 0.182583639376373 no 2767 0.19839860824647 3920 3883818
SGTC_2733 amorolfine 100 µM -0.848597440876007 0.182246760671052 no 2768 0.198052665734255 3948 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1999 st074831 12.5 µM -0.856476104672348 0.180119379875841 no 2769 0.195867242288898 3886 17112523
SGTC_1493 4348-0038 111 µM -0.857221286028107 0.179918977656244 no 2770 0.195661300358745 3914 800424
SGTC_2783 7738165 71.43 µM -0.857283481599221 0.179902257685238 no 2771 0.195644117635178 3916 17201110
SGTC_2545 solidagenone 89.61 µM -0.858672827100973 0.179529015777435 no 2772 0.195260523044254 3714 6708572 An anti ulcer agent
SGTC_2720 fluspirilene 36.88 µM -0.858806154696742 0.179493223484353 no 2773 0.195223735697944 3912 3396 An atypical antipsychotic.
SGTC_958 1222-0007 33 µM -0.858927555121056 0.179460636986994 no 2774 0.195190242924308 4002 7312461
SGTC_346 4513-0042 7.16 µM -0.858998486487609 0.179441599196724 no 2775 0.195170675513424 3912 2827372
SGTC_149 3970-0822 46.1 µM -0.859721629519061 0.179247581987113 no 2776 0.194971254419374 3928 3114250 YBL034C STU1
SGTC_1016 4226-1401 38 µM -0.859958413054885 0.179184082323385 no 2777 0.194905983577695 3886 2901613
SGTC_877 0771-0151 33.1 µM -0.862348736408544 0.178543847531943 no 2778 0.194247820594268 3959 6166523
SGTC_3057 9095946 49.47 µM -0.864052859290847 0.178088288591004 no 2779 0.19377942677039 3932 24540043
SGTC_2339 9000433 200 µM -0.865132477395716 0.177800056490728 no 2780 0.193483040413066 3947 2988954
SGTC_2222 6885208 172.143 µM -0.867282393140376 0.17722695767858 no 2781 0.192893650656883 3864 609514
SGTC_138 0850-0259 40.9225 µM -0.870801653074545 0.176291356570032 no 2782 0.191931231257233 3905 6813004
SGTC_693 4161-2696 114 µM -0.873837941100215 0.175486670647017 no 2783 0.191103257495709 3959 805759
SGTC_2406 ethylparaben 405.7 µM -0.877768310295975 0.174448496019861 no 2784 0.190034732569466 3992 8434 A possible steroid mimic.
SGTC_2649 anisomycin 9.56 µM -0.878042149187845 0.174376309399743 no 2785 0.189960422786058 3926 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2990 9074105 71.4286 µM -0.879507015731162 0.173990478538489 no 2786 0.189563215417349 3885 6502001
SGTC_625 k213-0058 121 µM -0.879692487752348 0.173941665847224 no 2787 0.189512960035317 4010 3655420
SGTC_2776 terbinafine 19.92 µM -0.883380948153179 0.172972742499462 no 2788 0.188515240447882 3966 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3198 9112019 49.47 µM -0.884207998683848 0.172755957097055 no 2789 0.18829197064484 4000 45595555
SGTC_2465 5809242 33.21 µM -0.885793738300556 0.172340789690029 no 2790 0.187864342332962 3960 2731748
SGTC_1210 3013-0140 750 nM -0.886213860117143 0.172230903038282 no 2791 0.187751148146532 3989 905973
SGTC_17 0960-0276 49.807 µM -0.888062945260899 0.171747789708131 no 2792 0.187253446674983 3940 6821114
SGTC_1713 st033146 12.748 µM -0.888973090643181 0.171510312806051 no 2793 0.187008770971882 3918 674619
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.889360412787643 0.171409315639329 no 2794 0.186904706620539 3947 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1992 st073643 23.3 µM -0.88954597282915 0.171360942931987 no 2795 0.186854863699606 3901 3161292
SGTC_2290 7904846 200 µM -0.889618372532027 0.171342071786927 no 2796 0.186835418787621 4013 2962154
SGTC_3036 9090181 49.47 µM -0.889874282936697 0.171275378813053 no 2797 0.186766697115907 3976 25236586
SGTC_1728 st035614 33.7865 µM -0.889971942915549 0.171249931959616 no 2798 0.186740475824356 3956 15945546
SGTC_2468 5987765 72.9 µM -0.890080333866985 0.171221691811864 no 2799 0.186711375980312 4003 26772094
SGTC_1025 k007-0731 70 µM -0.890143376966453 0.171205267950313 no 2800 0.186694452017759 3925 6256118
SGTC_3301 9125354 19.7965 µM -0.893601677651364 0.170305861954412 no 2801 0.185767524216489 3930 41905162
SGTC_145 3737-0113 38.366 µM -0.893896352214783 0.170229365644019 no 2802 0.185688674841423 3937 6849351
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.893913710453234 0.170224860203072 no 2803 0.185684030750712 3916 4330530
SGTC_1457 k015-0032 57.3 µM -0.895380412922079 0.169844444250302 no 2804 0.185291883774856 3966 4302660
SGTC_3248 9135562 49.47 µM -0.895734884643669 0.169752587419082 no 2805 0.185197187156782 3964 17650701
SGTC_3130 9127414 49.47 µM -0.896733609720922 0.169493951916078 no 2806 0.184930540849462 3954 1494646
SGTC_482 fipronil 114 µM -0.898848616989757 0.16894707285072 no 2807 0.184366650104961 4031 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_770 0389-1121 67.2 µM -0.898868376106927 0.168941969070519 no 2808 0.184361387094563 4100 6753108
SGTC_144 4161-2749 112.381 µM -0.899794321233811 0.16870290850814 no 2809 0.184114858497969 3887 797501 YMR168C CEP3
SGTC_1321 1326-2144 215 µM -0.901323890712647 0.168308480628853 no 2810 0.183708067438956 3983 3513030
SGTC_2005 4024620 188 µM -0.903875931740381 0.167651711038292 no 2811 0.183030596377809 3966 236743
SGTC_2272 7805186 180 µM -0.904620542518328 0.167460396395567 no 2812 0.182833224301113 3984 2956062 YPR165W RHO1
SGTC_407 eburnamonine 100 µM -0.905449514716367 0.167247572107392 no 2813 0.182613647101371 3834 3195
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.907825756067097 0.166638479820478 no 2814 0.181985144116087 3913 6708514
SGTC_3272 9137413 49.47 µM -0.908305037178738 0.166515801350204 no 2815 0.181858540967467 3913 17614870
SGTC_3291 9121177 71.43 µM -0.909739875925863 0.166148883630861 no 2816 0.181479854617739 3998 17015612
SGTC_167 3672-0051 66.205 µM -0.909888519204596 0.166110902372431 no 2817 0.181440652535544 3913 3237971
SGTC_1848 st056003 16.4 µM -0.912313847274139 0.165491976256496 no 2818 0.180801763476531 4012 146492
SGTC_1531 st059297 52.4 µM -0.914757970634396 0.164869764809647 no 2819 0.180159351830831 3994 7566702
SGTC_2652 actinonin 100 µM -0.915483439357729 0.164685370963962 no 2820 0.17996894624262 3973 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1092 toremifene 6.32 µM -0.916053266001448 0.164540630707756 no 2821 0.17981947891756 3978 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_252 miconazole 1.30953 nM -0.917333404124475 0.164215766736258 no 2822 0.179483979110837 3913 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1892 st058411 7.36 µM -0.91871116290357 0.163866594383113 no 2823 0.179123334728389 4010 3934738
SGTC_657 3534-0529 86.7 µM -0.922041848918601 0.163024473666311 no 2824 0.178253373616147 4058 1049549
SGTC_3245 9134821 49.47 µM -0.922206193537231 0.162982994221835 no 2825 0.178210516544347 3988 17014901
SGTC_756 0508-1999 28.3 µM -0.923462301291724 0.162666187963946 no 2826 0.177883168792188 3999 6753853
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.924232946491655 0.162472019910207 no 2827 0.177682522757726 4028 23665772 A membrane-active detergent.
SGTC_2648 atorvastatin 78.68 µM -0.926506996982904 0.161899940671593 no 2828 0.177091281282596 4014 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.927856343933166 0.161561108756756 no 2829 0.176741046217022 3983 15053
SGTC_1353 1498-1206 8.11 µM -0.929026602742173 0.161267621930618 no 2830 0.176437649913956 4046 6756808
SGTC_1365 1672-3266 55.4 µM -0.929098357359167 0.161249638058898 no 2831 0.176419057844401 4047 6415873
SGTC_2629 bisabolol 100 µM -0.929513941623031 0.161145505836761 no 2832 0.176311401742937 4041 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1158 4092-0494 91.8 µM -0.929532619279886 0.161140826839468 no 2833 0.176306564317275 4101 1148199
SGTC_1018 4259-0013 28.1 µM -0.93421622155468 0.15997032145297 no 2834 0.175096184862451 4092 6801262
SGTC_929 2805-0021 398 µM -0.934819265585113 0.159820016403682 no 2835 0.174940724628084 4085 3098024
SGTC_2389 9091542 195.52 µM -0.935188989183991 0.159727910748692 no 2836 0.174845455977321 3999 3626624 YOL127W RPL25
SGTC_1843 st055809 45.5 µM -0.938140980918915 0.15899375562137 no 2837 0.174085981922152 4082 16413835
SGTC_1494 4358-1428 177 µM -0.94005536620775 0.158518835137399 no 2838 0.173594580865166 4048 1564571
SGTC_2334 9017922 200 µM -0.941349732773851 0.158198256568991 no 2839 0.173262832239086 4098 3163164
SGTC_878 0828-0289 13.7 µM -0.942108365866146 0.158010562170118 no 2840 0.173068580893934 3977 745350 YLR208W SEC13
SGTC_2526 patulin 37.61 µM -0.943311864270575 0.15771310311966 no 2841 0.172760704553272 4071 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1306 1185-0270 9.02 µM -0.944773868625014 0.157352246390182 no 2842 0.17238716772271 4057 1548076
SGTC_3070 9117005 49.47 µM -0.945801924224877 0.15709882359026 no 2843 0.172124811977593 4090 8779016
SGTC_193 1273-0060 1.558 µM -0.947440588919725 0.156695436669022 no 2844 0.171707158314377 3838 2847393 YHR072W ERG7
SGTC_2086 5274770 176.623 µM -0.948352729821018 0.156471192330527 no 2845 0.171474957657073 4078 689278
SGTC_650 1328-0195 38 µM -0.950596103738034 0.155920571801156 no 2846 0.17090472363781 4008 2780821
SGTC_476 mead acid 10 µM -0.951002104927236 0.155821058294601 no 2847 0.170801653666942 4041 5312531 An omega 9 fatty acid.
SGTC_1187 1391-0724 117 µM -0.952102832985191 0.155551473465656 no 2848 0.170522416209398 4090 6997986
SGTC_3220 9131269 49.47 µM -0.952579649820998 0.155434789426531 no 2849 0.170401546042219 4048 17722206
SGTC_689 0833-0039 98 µM -0.952616588041443 0.155425752515783 no 2850 0.170392184718737 3989 5374726
SGTC_864 0469-0573 172 µM -0.95313799765725 0.155298226990074 no 2851 0.170260078030315 4001 689425
SGTC_1276 0871-0068 94.2 µM -0.954402927011523 0.154989139660615 no 2852 0.169939862607198 4040 3414906
SGTC_1783 st039459 87.517 µM -0.956973909144257 0.154362169253531 no 2853 0.169290212108216 4152 729761
SGTC_787 4152-0075 138 µM -0.957245149411215 0.15429612140226 no 2854 0.16922176665237 4047 9566539
SGTC_2836 9010338 19.48 µM -0.958450115655434 0.154002934307126 no 2855 0.168917917232091 4040 2994051
SGTC_992 3909-8734 162 µM -0.959136238345867 0.153836154756531 no 2856 0.168745058316003 4055 4288319
SGTC_577 r071-0003 38.6 µM -0.959518274281854 0.153743343048491 no 2857 0.168648859047723 4064 4568517 YMR134W ERG29
SGTC_1126 isoteolin 1.0172 µM -0.960710330086874 0.15345398365458 no 2858 0.168348917867845 3983 133323
SGTC_2933 9026794 32.47 µM -0.961447357251345 0.153275258400952 no 2859 0.168163641249454 4008 17586027
SGTC_3326 9140064 16.379 µM -0.964585904655879 0.152515721732055 no 2860 0.167376131080877 3977 1868434
SGTC_1435 4092-0789 56.7 µM -0.965322175296928 0.152337904598639 no 2861 0.167191734072846 4035 2248285
SGTC_3321 9137793 26.8275 µM -0.966560372364762 0.152039177363 no 2862 0.166881926363289 4011 4904192
SGTC_3192 9110362 49.47 µM -0.967639319156668 0.151779188257224 no 2863 0.166612266591626 4068 16649480
SGTC_2596 sinensetin 100 µM -0.968001749061016 0.151691921427966 no 2864 0.166521748090548 4072 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2170 morpholine 200 µM -0.969527205706198 0.151324983566916 no 2865 0.166141106495039 4084 121171 Reacts with secondary amines.
SGTC_1344 1488-0097 29.1 µM -0.970240273847358 0.151153662681746 no 2866 0.165963370154955 4078 747966
SGTC_2265 7929201 200 µM -0.970898724232993 0.150995578829706 no 2867 0.165799356766184 4015 1265108
SGTC_2044 5102272 200 µM -0.972077026135669 0.150712961308039 no 2868 0.165506115198268 4060 592666
SGTC_2808 7946468 45.46 µM -0.972229770627287 0.150676351112901 no 2869 0.165468126568902 4068 2970879
SGTC_1881 5652484 16 µM -0.9729027120202 0.150515129301101 no 2870 0.165300828483905 4033 2255129
SGTC_3156 9099931 49.47 µM -0.973179536285814 0.150448841724784 no 2871 0.16523203975987 4074 18111053
SGTC_1112 tnp00069 1.16933 µM -0.973462686937381 0.150381059372976 no 2872 0.165161698146244 4073 145826
SGTC_1767 st044992 70.3 µM -0.974925260939012 0.150031263408387 no 2873 0.164798667342284 4115 9600693
SGTC_257 daunorubicin 18.5 µM -0.975747580508736 0.149834832094006 no 2874 0.164594783590121 4082 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1865 st057639 52.2 µM -0.976372964152636 0.149685558668847 no 2875 0.164439837084848 4039 688818
SGTC_1374 2889-5571 141 µM -0.978336253474841 0.149217584102253 no 2876 0.163954022511338 4121 2853281
SGTC_3031 9088762 49.47 µM -0.978437636859283 0.14919344466206 no 2877 0.163928960575972 4048 205253
SGTC_3141 9094609 49.47 µM -0.979557011500415 0.148927094293758 no 2878 0.163652416825924 4018 25236309 YDL196W YDL196W
SGTC_963 1269-2853 151 µM -0.980761173996815 0.148640923948568 no 2879 0.163355264431001 4062 3668223
SGTC_3330 9141424 71.43 µM -0.981887750080394 0.148373525143133 no 2880 0.163077575672621 4151 27261020
SGTC_2986 9022445 71.43 µM -0.983439326126681 0.148005777358795 no 2881 0.162695631617178 4086 6459286
SGTC_1161 k007-0610 110 µM -0.983995532235333 0.147874096487823 no 2882 0.162558854817102 4048 5843850
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.987730285712427 0.146991931760109 no 2883 0.161642378978027 4117 279621
SGTC_1163 k060-0048 49.9 µM -0.990226216041612 0.14640435372815 no 2884 0.161031780683697 4066 6809982
SGTC_1328 1441-0025 69.2 µM -0.998029930803033 0.144577430527762 no 2885 0.159132422567174 4059 4562601
SGTC_2656 pseudo-anisatin 100 µM -0.999001375310802 0.144351085859632 no 2886 0.158897012523811 4119 6708809 A neurotoxin.
SGTC_850 0388-0143 75.9 µM -0.99940416002146 0.144257307889603 no 2887 0.158799472715621 4049 67273
SGTC_740 k014-0057 261 µM -0.999540260590884 0.144225629688064 no 2888 0.158766522980875 4074 4012779
SGTC_3067 9117431 49.47 µM -1.00034016150444 0.144039542863986 no 2889 0.158572958804972 4126 17150885
SGTC_2267 7931562 200 µM -1.00142032130417 0.143788514413349 no 2890 0.158311821821652 4018 934880
SGTC_2713 st079149 53.4 µM -1.00221020855818 0.143605132073076 no 2891 0.158121039180956 4117 3103253
SGTC_1453 4237-0541 195 µM -1.00470402024914 0.143027198326955 no 2892 0.157519695874441 4088 739892
SGTC_2240 6690706 185.951 µM -1.00543725512689 0.142857572608172 no 2893 0.157343174131597 3945 805876
SGTC_2350 9023895 38.85 µM -1.00565963340148 0.142806154754892 no 2894 0.157289663652735 4117 2997209
SGTC_1979 st071809 45.3 µM -1.00701890122956 0.142492139542826 no 2895 0.156962845607524 4183 4976333
SGTC_2349 9023730 187.07 µM -1.00734416611302 0.142417066829187 no 2896 0.156884706237897 4118 4126287
SGTC_1978 st071761 42 µM -1.00902202860899 0.142030233045902 no 2897 0.156482034844511 4117 5147680
SGTC_3347 9188721 44.724 µM -1.00985700761986 0.141837992644999 no 2898 0.156281901476405 4127 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1751 st044839 27.194 µM -1.01050103780805 0.141689835540753 no 2899 0.156127651233235 4112 5291326
SGTC_1291 0993-0025 5.79 µM -1.01060518237788 0.141665887262361 no 2900 0.156102717224082 4113 4353356
SGTC_49 0717-0965 32.132 µM -1.01266597878748 0.141192566403895 no 2901 0.155609866670834 4191 5889349 YGL099W LSG1
SGTC_1213 1315-0166 115 µM -1.01353800617066 0.140992603575964 no 2902 0.155401626002485 4190 768401
SGTC_823 0417-1665 178 µM -1.01385667189562 0.140919578929968 no 2903 0.155325574331659 4094 3429856
SGTC_3352 9151559 45.5865 µM -1.01428494168359 0.140821478106261 no 2904 0.155223403624993 4114 17159339
SGTC_2304 7443016 91.4 µM -1.0144799197495 0.140776831170569 no 2905 0.155176903142966 4032 939854
SGTC_3274 9138298 49.47 µM -1.01578700502774 0.140477777054793 no 2906 0.154865412763084 4060 17015756
SGTC_1724 st037281 8.293 µM -1.01723095427021 0.140147910942789 no 2907 0.154521786925141 4073 574124 YDL195W SEC31
SGTC_311 1315-0136 58 µM -1.01733426740303 0.140124329538323 no 2908 0.154497220172442 4140 6759207
SGTC_2908 7930301 100 µM -1.0175764941952 0.140069051415967 no 2909 0.154439631367742 4091 2223178
SGTC_3340 9146634 11.102 µM -1.01913518319618 0.139713700358017 no 2910 0.154069396520568 4126 4907387
SGTC_2205 7238770 200 µM -1.01993009660248 0.13953271161893 no 2911 0.153880807292801 4169 279867
SGTC_531 3788-1495 174 µM -1.02039523191134 0.139426881923819 no 2912 0.153770527149405 4074 2896655
SGTC_3317 9138495 8.753 µM -1.02090985808785 0.139309855482353 no 2913 0.153648574064027 4027 17020139
SGTC_3134 9127454 49.47 µM -1.02272757020945 0.138897041180388 no 2914 0.153218336021055 4151 24262820
SGTC_3088 9117578 49.47 µM -1.02328820426336 0.138769885766428 no 2915 0.153085799626833 4154 678341
SGTC_808 0711-0032 135 µM -1.02452949190115 0.138488635901788 no 2916 0.152792624145335 4038 4252555
SGTC_694 1315-0438 43.2 µM -1.02524804186239 0.138326005109264 no 2917 0.152623082564023 4092 6793154
SGTC_2127 5253358 187.912 µM -1.02626559822312 0.138095922413432 no 2918 0.152383204134998 4019 20612
SGTC_673 1082-0474 110 µM -1.02631761541745 0.138084167666594 no 2919 0.152370948343999 4124 3098046
SGTC_2922 7999257 32.47 µM -1.02694717827363 0.137941954351148 no 2920 0.152222668677667 4072 2988377
SGTC_443 clozapine 122 µM -1.02857729590491 0.137574187938582 no 2921 0.151839175694942 4045 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_298 1391-0729 10 µM -1.02997655771154 0.137259038564248 no 2922 0.15151050508253 4065 3237558
SGTC_2241 6772625 37.8075 µM -1.03018364816173 0.137212438445088 no 2923 0.151461902113852 3972 2285411
SGTC_1135 dihydrocapsaicin 536.708 nM -1.03093966649882 0.137042408657726 no 2924 0.151284556857269 4043 107982 A Capsaicinoid.
SGTC_2210 7115885 190.385 µM -1.03399230051815 0.136357330737237 no 2925 0.150569881353595 4198 2927039
SGTC_1694 st024011 44.9 µM -1.03411568478281 0.13632968995797 no 2926 0.150541042278969 4142 2787533
SGTC_2487 5918373 44.05 µM -1.03415337856237 0.136321246489783 no 2927 0.150532232701887 4205 2876279
SGTC_2793 7325131 81.82 µM -1.0346384479617 0.13621262207934 no 2928 0.150418895667257 4093 4176441
SGTC_1144 3486-0183 12.5 µM -1.03724860287308 0.135629131924566 no 2929 0.149810006143536 4113 6744069
SGTC_2569 tetrandrine 100 µM -1.03793683021358 0.135475567021503 no 2930 0.149649732702066 4148 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1463 k081-0032 34.1 µM -1.04318671220955 0.134308076377614 no 2931 0.148430913209332 3800 977755
SGTC_1569 carminic acid 40.6 µM -1.04402219716876 0.134122916957252 no 2932 0.14823755998652 4227 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_350 k064-0020 19.8 µM -1.0458180722096 0.133725510552647 no 2933 0.147822517826587 4159 2790705
SGTC_3092 9117248 49.47 µM -1.04597627384238 0.133690541195775 no 2934 0.14778599339501 4243 17141857
SGTC_914 3820-6779 408 µM -1.04696527485073 0.133472071996545 no 2935 0.14755779708186 4097 2893481
SGTC_2411 st077133 39.94 µM -1.0477615340207 0.1332963577765 no 2936 0.147374244506232 4207 1403142 YNL221C POP1
SGTC_429 1112-0049 25.5 µM -1.04905716060171 0.133010786128012 no 2937 0.147075905603613 4112 2836170
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.05022461627408 0.132753825852048 no 2938 0.146807427194947 4114 6312947
SGTC_1768 st044301 37.178 µM -1.05538553937579 0.131621989699108 no 2939 0.145624516868479 4159 3931349
SGTC_3268 9137683 49.47 µM -1.05586802432177 0.131516517909599 no 2940 0.145514257306902 4206 1953228
SGTC_719 2810-4230 27.3 µM -1.05719172834119 0.131227454261325 no 2941 0.145212047063094 4134 721079
SGTC_659 k018-0002 107 µM -1.05825312770163 0.130995988553953 no 2942 0.144970027981446 4155 6797879 YHR007C ERG11
SGTC_2804 7954240 19.48 µM -1.05829016085806 0.130987917608075 no 2943 0.144961588628325 4190 828705
SGTC_981 1488-1094 54.9 µM -1.05866041030994 0.130907244933808 no 2944 0.144877231992576 4127 3449522
SGTC_296 1222-0039 74.9 µM -1.05893870307403 0.130846631065837 no 2945 0.144813848282829 4159 5984176
SGTC_928 2764-0428 58.7 µM -1.06010433312437 0.130592960488669 no 2946 0.144548568358784 4180 662578
SGTC_820 1582-0060 59.9 µM -1.06389839724893 0.129769631842981 no 2947 0.143687364586649 4171 3848840
SGTC_649 1123-0311 367 µM -1.06504111754359 0.129522362365778 no 2948 0.143428661643946 4054 693629 YIL048W NEO1
SGTC_2897 9048598 12.99 µM -1.06909030144768 0.128648801322284 no 2949 0.142514490700375 4144 6467404
SGTC_1318 1280-3875 124 µM -1.06985402992469 0.128484495758005 no 2950 0.142342508937203 4156 373245
SGTC_1789 tunicamycin 25 nM -1.0735732870215 0.127686431414384 no 2951 0.141506987762293 4069 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2090 5301565 104.445 µM -1.07457302350592 0.127472500536309 no 2952 0.141282967471772 4165 2056344
SGTC_2766 oltipraz 83.91 µM -1.07668116055717 0.127022203336457 no 2953 0.140811365854646 4145 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2974 9094440 9.66 µM -1.08016584464208 0.126280305941396 no 2954 0.140034167505871 4189 25236134
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.08023862242119 0.126264843642372 no 2955 0.140017966817866 4213 6708760
SGTC_906 1165-0455 526 µM -1.08089285026678 0.126125906246939 no 2956 0.139872389696049 4155 3252859
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.08303926317308 0.125670824272424 no 2957 0.139395497940437 4125 97141
SGTC_866 0495-0101 262 µM -1.08336104710914 0.125602698585804 no 2958 0.139324099181042 4154 635694
SGTC_154 3389-1638 511.116 µM -1.08567376857693 0.125113824642423 no 2959 0.138811675012236 4172 5238686
SGTC_1961 st076550 68.7 µM -1.08575852454517 0.125095933804862 no 2960 0.138792920247172 4207 1579337
SGTC_2251 lansoprazole 556 µM -1.08690624957752 0.12485384049455 no 2961 0.138539122043271 4102 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1718 roemerine 11.9335 µM -1.0880639013872 0.124609985104635 no 2962 0.138283449240525 3910 235224 An aporphine alkaloid with mutagenic activity.
SGTC_123 0083-0120 66.675 µM -1.09284139596153 0.123607145113836 no 2963 0.137231721353239 4160 16001701
SGTC_3035 9091303 49.47 µM -1.09523036507603 0.123107803877593 no 2964 0.136707862921849 4253 25237002
SGTC_1818 st052136 56.3 µM -1.09904704274064 0.122312980636379 no 2965 0.135873773577196 3901 674169
SGTC_691 1548-0686 185 µM -1.10108147179395 0.121890785555465 no 2966 0.135430600089703 4182 46495133
SGTC_187 1488-2104 32.728 µM -1.1011314920534 0.121880418006612 no 2967 0.135419716328975 4207 2852859
SGTC_1696 st025591 34.7925 µM -1.10282139021854 0.121530521818321 no 2968 0.135052368558557 4201 2787147
SGTC_3232 9132874 49.47 µM -1.10514739360473 0.121050074659264 no 2969 0.134547863666695 4154 3784940
SGTC_1722 st034304 3.6505 µM -1.1077264795653 0.12051891610152 no 2970 0.133989979966589 4176 4036148 YLR033W RSC58
SGTC_1688 st021091 57.6 µM -1.114118009894 0.119209670654125 no 2971 0.132614281639823 4223 3656366
SGTC_2163 5671233 125 µM -1.11883893388037 0.118249101356292 no 2972 0.13160442927483 4182 701023
SGTC_2712 st079126 47.7 µM -1.12007335953996 0.117998837109471 no 2973 0.131341251030268 4198 3152970
SGTC_803 4488-1585 147 µM -1.12292922695989 0.117421282700461 no 2974 0.13073377672419 4202 747204
SGTC_2753 fluvastatin 17.09 µM -1.12318212982062 0.117370233712012 no 2975 0.130680075279483 4224 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_970 1315-0089 19.5 µM -1.12363071688128 0.117279724112734 no 2976 0.130584859731194 4170 6811083 YLR033W RSC58
SGTC_1948 st076329 66.6 µM -1.12652745732105 0.116696450747502 no 2977 0.129971162632909 4107 24208413
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.13078278089718 0.115843354507444 no 2978 0.129073264549782 4230 66535 A nucleotide analog.
SGTC_895 0964-0006 13.7 µM -1.13246413691693 0.11550750418887 no 2979 0.128719676839238 4196 6738897
SGTC_1458 k015-0034 6.33 µM -1.14228634309972 0.113559345237456 no 2980 0.12666750803309 4263 3598957
SGTC_2735 sertaconazole 140 nM -1.1438700861742 0.113247428339227 no 2981 0.126338759225884 4355 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3037 9091026 49.47 µM -1.14400757689148 0.113220378517199 no 2982 0.126310247374296 4157 25236398 YIL048W NEO1
SGTC_1188 1403-0014 4.57 µM -1.14480272623466 0.113064031836563 no 2983 0.126145442886388 4213 9614867
SGTC_2543 pimpinellin 60.67 µM -1.14776707211144 0.112482523698443 no 2984 0.125532367002738 4054 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.14892970194281 0.112255037883334 no 2985 0.125292484486006 4263 94937 An inhibitor of serotonin biosynthesis.
SGTC_1945 st075991 56.6 µM -1.1489642389993 0.112248285226916 no 2986 0.125285363439148 4229 1084980
SGTC_1588 farnesol 29.9 µM -1.15180799700511 0.111693271709949 no 2987 0.124699990490333 4251 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2292 7671323 168.05 µM -1.15364074538431 0.111336617895643 no 2988 0.124323743152473 4302 937504
SGTC_1838 st055369 84.5 µM -1.15634608895265 0.110811647572968 no 2989 0.123769811744177 4241 676036
SGTC_320 4092-0846 5.34 µM -1.16112993370247 0.109887690737342 no 2990 0.122794531609599 4205 1359356
SGTC_1831 st055328 12 µM -1.16124883572889 0.109864796504086 no 2991 0.122770359948451 4244 1103068
SGTC_1091 telmisartan 47.6 µM -1.16333016333882 0.109464597329933 no 2992 0.122347786052628 4288 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_308 4092-1169 104 µM -1.1641051821537 0.10931584399231 no 2993 0.122190694406074 4185 2268590 YDL196W YDL196W
SGTC_2907 7721985 69.9 µM -1.16577955525064 0.10899496885852 no 2994 0.121851792653138 4268 3267881
SGTC_3217 9129673 49.47 µM -1.16928241065621 0.108325876146656 no 2995 0.121144933732574 4275 17248312
SGTC_2227 7312221 64.1025 µM -1.17012309985343 0.108165733911281 no 2996 0.120975716847103 4359 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1234 0326-0494 15.5 µM -1.17074667091843 0.108047060473061 no 2997 0.120850309740445 4344 1547813
SGTC_1103 duloxetine 36.1 µM -1.17218785446072 0.107773143835443 no 2998 0.120560821786988 4333 60835 A selective serotonin reuptake inhibitor.
SGTC_1392 3455-1037 33.9 µM -1.17285306102379 0.10764688110012 no 2999 0.120427367770146 4256 981132
SGTC_103 0844-0104 51.839 µM -1.173088150154 0.107602284374302 no 3000 0.120380228983086 4121 5375804
SGTC_3169 9102970 49.47 µM -1.17722767603453 0.106819190770705 no 3001 0.119552322489863 4326 17027839
SGTC_2184 6075246 200 µM -1.17857370177647 0.106565444879169 no 3002 0.119283984292777 4260 2267320
SGTC_2432 5630864 12.22 µM -1.18211898743364 0.105899188767215 no 3003 0.118579245701077 4308 5714970
SGTC_2138 5575593 77.673 µM -1.1840319133708 0.105540950576105 no 3004 0.118200215070908 4279 762213
SGTC_2484 5809818 12.04 µM -1.1852803908298 0.105307618362952 no 3005 0.117953301971928 4239 2870548
SGTC_2603 homopterocarpin 100 µM -1.18590775016998 0.1051905100215 no 3006 0.117829366095007 4260 101795 A weak amylase inhibitor.
SGTC_1373 2887-0003 58.5 µM -1.18782912397458 0.104832436041892 no 3007 0.11745036885658 4229 776948
SGTC_376 3970-0862 59.1 µM -1.18854670979085 0.104698930844701 no 3008 0.117309044343417 4311 3135186
SGTC_2561 acetosyringone 100 µM -1.19149615003772 0.104151487437951 no 3009 0.11672943356863 4255 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2762 leflunomide 42.06 µM -1.19208824130954 0.104041840370583 no 3010 0.116613323576195 4256 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2683 piperine 63.03 µM -1.19210136003556 0.10403941191315 no 3011 0.11661075190197 4258 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2686 alizarin 95.37 µM -1.19432286730711 0.103628772785134 no 3012 0.11617584796356 4266 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3140 9094243 49.47 µM -1.19470118857079 0.103558958560732 no 3013 0.116101898959933 4258 19291112
SGTC_880 0833-0487 87.2 µM -1.19703889591543 0.103128322321251 no 3014 0.115645697300852 4280 76075
SGTC_1788 fluconazole 20 µM -1.19819071669109 0.102916620774971 no 3015 0.115421389295532 4308 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3163 9099914 49.47 µM -1.19838661240958 0.102880647108901 no 3016 0.115383270934808 4326 16268368
SGTC_1255 0566-0045 221 µM -1.20116047005388 0.102372244980802 no 3017 0.114844480002875 4299 2788469
SGTC_2031 5180455 200 µM -1.20256580011044 0.102115369662574 no 3018 0.114572194413744 4263 29949
SGTC_1342 1486-1464 234 µM -1.20477646421678 0.101712239734086 no 3019 0.114144804086517 4322 3253938
SGTC_1842 st055362 61.2 µM -1.20478735612556 0.101710256391573 no 3020 0.114142701155821 4246 676032
SGTC_2684 capsaicin 100 µM -1.20678913257724 0.10134622447646 no 3021 0.113756681153109 4316 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1364 1653-0028 37.6 µM -1.20739003822018 0.101237132581008 no 3022 0.113640985072035 4288 5718652
SGTC_2714 st079313 56.9 µM -1.20886747952772 0.100969273189997 no 3023 0.113356880897141 4269 2939799
SGTC_879 0831-1030 162 µM -1.2107368775363 0.100631093156868 no 3024 0.11299813202752 4303 1549252
SGTC_1970 st070122 35.8 µM -1.21366534799273 0.100102985674684 no 3025 0.112437770924449 4322 102928
SGTC_50 0929-0078 56.389 µM -1.21919765941785 0.0991108404115833 no 3026 0.111384590054879 4147 1377751
SGTC_2234 tolnaftate 200 µM -1.2205713471468 0.098865606460266 no 3027 0.111124180245528 4370 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2830 7992007 71.43 µM -1.22345907838636 0.098351530161134 no 3028 0.110578175600724 4179 1952075
SGTC_2224 6650123 117.647 µM -1.22468532772702 0.0981338253768806 no 3029 0.110346902193417 4315 2908370
SGTC_3211 9128781 49.47 µM -1.2267013612484 0.0977766722784359 no 3030 0.109967427951337 4281 17194361
SGTC_1853 st056710 91.2 µM -1.22880956578543 0.0974042107031056 no 3031 0.109571607083261 4370 269167
SGTC_3185 9108267 49.47 µM -1.23183138409161 0.0968721553928931 no 3032 0.109006038569644 4315 4910486
SGTC_2732 terfenadine 20 µM -1.2319373000837 0.096853545416684 no 3033 0.108986253290111 4376 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1747 st037496 66.6 µM -1.23624465655113 0.0960989436196314 no 3034 0.108183817976226 4280 723305
SGTC_5 0352-0601 109.883 µM -1.24059551824214 0.0953411174951167 no 3035 0.107377604210265 4216 762456
SGTC_326 k292-0812 17.5 µM -1.24304101870802 0.0949171002843937 no 3036 0.106926359238623 4299 3579357
SGTC_2293 7624732 200 µM -1.24442337203632 0.0946780340975622 no 3037 0.106671892722622 4210 894453
SGTC_1192 1488-0095 21.4 µM -1.25018333006283 0.0936866750826381 no 3038 0.105616292435213 4355 915875
SGTC_1663 st014140 55.4 µM -1.25461995700735 0.0929283183222246 no 3039 0.104808377589316 4397 4207120
SGTC_1407 3909-7909 12.3 µM -1.25657300692848 0.0925959240423479 no 3040 0.104454147104803 4345 4411780
SGTC_1129 3453-1384 223 µM -1.25869779422857 0.092235301152144 no 3041 0.104069754223444 4377 1084452
SGTC_924 2046-0044 21.3 µM -1.2622439441433 0.0916357589367732 no 3042 0.103430510284801 4319 3623589
SGTC_1019 4262-0212 3.4 µM -1.26228255012283 0.0916292478093551 no 3043 0.103423566726345 4338 4677213
SGTC_293 4049-0273 38.5 µM -1.26293851357272 0.0915186680743582 no 3044 0.103305638773292 4215 1380311
SGTC_142 0335-0849 62.6745 µM -1.26499128539528 0.0911732589344645 no 3045 0.102937225915467 4315 3889043 YPR107C YTH1
SGTC_723 4182-0001 115 µM -1.27007037837617 0.0903227832553394 no 3046 0.102029780976007 4353 744821 YLR208W SEC13
SGTC_1093 fluphenazine 7.97 µM -1.27320769836527 0.0898004022882211 no 3047 0.101472174760815 4373 6602611 An atypical antipsychotic.
SGTC_1572 epiandrosterone 68.9 µM -1.27916006937516 0.0888154778753374 no 3048 0.100420347004299 4290 441302 A steroid.
SGTC_2016 5121758 140 µM -1.28196350368312 0.088354396358677 no 3049 0.0999277246253607 4291 2795203
SGTC_1643 st009866 20.2 µM -1.28242932279108 0.08827795611143 no 3050 0.0998460416965797 4315 3156273 YOR207C RET1
SGTC_2124 5246320 200 µM -1.29279190686672 0.0865901915132891 no 3051 0.0980415201296813 4375 579342
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.29316787061991 0.0865294145148258 no 3052 0.0979765026785992 4437 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_208 k072-0098 12.366 µM -1.29324649421494 0.0865167085295633 no 3053 0.097962909869581 4337 5948901
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.29579502537687 0.0861056075127894 no 3054 0.0975230561974898 4476 16725076
SGTC_918 glabranin 770.725 nM -1.29598306828138 0.0860753324909199 no 3055 0.0974906591461943 4365 124049 Also referred to as licorice root.
SGTC_1454 4239-0054 42.6 µM -1.29822717668133 0.0857146440953432 no 3056 0.0971046410179726 4439 1340767
SGTC_475 α-linolenic acid 10 µM -1.29958549747246 0.085496875912373 no 3057 0.0968715364396638 4379 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2926 9010726 65.15 µM -1.30317455787155 0.0849234660639976 no 3058 0.0962575870049913 4365 2994293
SGTC_2119 5528445 120.635 µM -1.30414430150896 0.0847690298315175 no 3059 0.0960921932069561 4393 791935
SGTC_126 0417-1624 672.48 µM -1.30600249545057 0.0844736922543918 no 3060 0.0957758544749799 4421 41912 YDL195W SEC31
SGTC_947 3447-0010 211 µM -1.30729040819282 0.0842694474147306 no 3061 0.0955570502897834 4334 748350
SGTC_1479 0549-0158 134 µM -1.30872239247859 0.0840427902381593 no 3062 0.0953142018535094 4423 5440202
SGTC_2065 5221596 34.26 µM -1.30913752836128 0.0839771674038197 no 3063 0.0952438845050359 4322 788581
SGTC_2695 st077686 51.995 µM -1.31121674073367 0.0836490735900794 no 3064 0.094892274026505 4366 2876092
SGTC_708 3448-5400 146 µM -1.31154137826919 0.0835979337499778 no 3065 0.0948374618024516 4332 3462195
SGTC_2021 4019055 173 µM -1.31284221052259 0.083393250537878 no 3066 0.0946180616157987 4172 44827708 YER133W GLC7
SGTC_1335 1486-0900 202 µM -1.3131113662473 0.0833509465256815 no 3067 0.0945727121879584 4368 X1335
SGTC_2882 9058044 58.44 µM -1.31329983364446 0.083321334143768 no 3068 0.0945409672897348 4395 18076804
SGTC_578 3460-0051 92 µM -1.31512788632142 0.0830345170502839 no 3069 0.0942334629803292 4430 2876744
SGTC_2361 9034121 116 µM -1.31539513810661 0.0829926481751828 no 3070 0.0941885693340745 4400 6496917
SGTC_1729 st035615 45.989 µM -1.31594104595329 0.0829071731299899 no 3071 0.0940969153545514 4380 17385451
SGTC_1612 st002233 45.4 µM -1.31821446225781 0.0825519270145207 no 3072 0.0937159327644066 4385 1035021
SGTC_373 0844-0104 25.9 µM -1.31951878894672 0.0823486296723272 no 3073 0.0934978664588308 4400 5375804
SGTC_3206 9114350 49.47 µM -1.32685380466453 0.0812123819627265 no 3074 0.0922785240352455 4245 17087243
SGTC_1515 3460-0031 42.1 µM -1.32799754980569 0.0810362786816466 no 3075 0.0920894581766667 4349 2876596
SGTC_1800 st050079 29.0735 µM -1.32847626481053 0.0809626561985419 no 3076 0.0920104097805462 4209 3645560
SGTC_1371 2421-0008 32.7 µM -1.32864886655812 0.0809361238375469 no 3077 0.091981921034722 4381 2827552
SGTC_2930 9013230 14.89 µM -1.33009892763467 0.0807134794186967 no 3078 0.0917428394120314 4364 2995857
SGTC_2430 5571206 200 µM -1.33156596147968 0.0804886999520183 no 3079 0.0915014281677645 4374 1731771
SGTC_542 3381-0244 89.3 µM -1.33424208093184 0.080079882575785 no 3080 0.0910622662438526 4410 1112843
SGTC_1775 st081588 35.1725 µM -1.33510546260833 0.0799483235593338 no 3081 0.090920915928812 4382 1426443 YGL099W LSG1
SGTC_549 1661-1316 519 µM -1.34185046690987 0.0789261639226764 no 3082 0.0898222425161263 4419 2857282
SGTC_1734 st037168 69.4 µM -1.34203258127283 0.0788987036230465 no 3083 0.0897927158793214 4404 708907
SGTC_1067 clotrimazole 1.36 µM -1.34208151994172 0.0788913255899712 no 3084 0.0897847825660582 4434 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1709 st033179 39.1045 µM -1.34556957959612 0.0783668080248637 no 3085 0.0892206838814787 4402 573381
SGTC_2782 7736369 71.43 µM -1.34609298478757 0.0782883295740674 no 3086 0.0891362653905246 4396 2950836 YOL077C BRX1
SGTC_1102 cgs 12066b 26.1 µM -1.34786320086818 0.0780233481230922 no 3087 0.0888511929060552 4410 6438352 A 5-HT1B full agonist.
SGTC_2853 9015042 58.44 µM -1.34939956970463 0.0777939230224014 no 3088 0.0886043294798368 4322 6457456
SGTC_962 1254-0300 21.5 µM -1.35093688592285 0.077564869322021 no 3089 0.0883578255623478 4368 7340576
SGTC_841 0251-0215 91.2 µM -1.35095536986182 0.0775621184111945 no 3090 0.0883548648321168 4438 3888614
SGTC_2371 9071574 200 µM -1.35771360934114 0.0765612663526074 no 3091 0.087277288347804 4425 45596039
SGTC_2759 disulfiram 3.38 µM -1.35871096808198 0.0764143995061339 no 3092 0.0871190975766997 4314 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1087 pterostilbene 9.05 µM -1.35955803483656 0.0762898324412552 no 3093 0.0869849128108136 4406 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1352 1496-0991 99 µM -1.36067054050768 0.0761264655632263 no 3094 0.0868089141854583 4409 3000039
SGTC_1265 0819-1001 68.8 µM -1.3618771463377 0.0759495816463912 no 3095 0.0866183298356108 4358 3106768
SGTC_2380 9035439 200 µM -1.36554105486511 0.0754143841407351 no 3096 0.0860415293358607 4474 6462575
SGTC_1440 4100-1550 40 µM -1.37006740903646 0.0747571814719537 no 3097 0.0853329301258881 4426 742806
SGTC_1105 epirubicin 18.1 µM -1.3720139411397 0.0744759027282652 no 3098 0.085029548956701 4446 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1699 st031318 29.054 µM -1.37292648861178 0.0743443158292427 no 3099 0.084887600450365 4473 5340658
SGTC_198 3454-2873 16.191 µM -1.37648949173574 0.0738322396276699 no 3100 0.0843350692236513 4433 710957
SGTC_3072 9116419 49.47 µM -1.37738556511121 0.0737038808124932 no 3101 0.0841965366730976 4433 17170162
SGTC_1184 1269-1718 139 µM -1.37972617324493 0.0733694031178006 no 3102 0.0838354855401195 4467 5403821
SGTC_2342 7990637 118.86 µM -1.38084030277533 0.0732106001413253 no 3103 0.0836640342345375 4407 2033102 YER133W GLC7
SGTC_854 0422-0053 192 µM -1.38572041582908 0.072518108140311 no 3104 0.0829161458394963 4448 3596728
SGTC_1399 3562-5772 25 µM -1.38737216857784 0.0722848631191813 no 3105 0.0826641535382311 4421 23847490
SGTC_3001 9076041 71.4286 µM -1.38899455805671 0.0720563245898875 no 3106 0.0824172024306969 4426 16004211
SGTC_2256 7954252 200 µM -1.39111636184554 0.0717582723288752 no 3107 0.0820950720410099 4432 2972920
SGTC_1957 st077035 62.4 µM -1.39507066210841 0.071205331716547 no 3108 0.0814972660611002 4442 705593
SGTC_989 1501-0895 10.3 µM -1.39567495973382 0.0711211200633379 no 3109 0.0814061990451637 4411 2830112
SGTC_648 0375-0473 33.3 µM -1.39718679674332 0.0709107736348082 no 3110 0.0811787030325189 4409 1713139
SGTC_2108 5365811 200 µM -1.39811324438721 0.0707821105418717 no 3111 0.0810395316355196 4437 780283
SGTC_481 bay k-8644 50 µM -1.40460455088943 0.069885637492335 no 3112 0.0800694513094519 4400 2303 A calcium channel antagonist.
SGTC_1684 st024538 14.6195 µM -1.40596268685509 0.0696991840579421 no 3113 0.0798676025014174 4403 6732859
SGTC_2137 5261020 140 µM -1.40622943747128 0.0696626078922312 no 3114 0.0798280027594668 4420 763655
SGTC_422 cantharidin 155 µM -1.40634535301751 0.0696467184539555 no 3115 0.0798107994594901 4352 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_509 pifithrin 175 µM -1.41410763323047 0.0685890193206838 no 3116 0.0786651511327302 4514 4817 A p53 inhibitor.
SGTC_94 0334-0113 514.748 µM -1.4208845233757 0.0676757589852599 no 3117 0.0776751664933498 4462 6795178
SGTC_521 r062-0005 13.8 µM -1.42178701777997 0.0675548501107794 no 3118 0.0775440447401909 4372 2832033
SGTC_3020 9089140 49.47 µM -1.42450351981824 0.067191922454001 no 3119 0.0771503834498721 4464 17217859
SGTC_1045 1348-1485 165 µM -1.42784815915144 0.066747147879144 no 3120 0.0766677838470163 4420 6810614
SGTC_2801 7907800 81.82 µM -1.42912655221621 0.0665777485387109 no 3121 0.0764839315640818 4434 6620925
SGTC_3348 9149464 3.537 µM -1.43381163566087 0.0659597734413221 no 3122 0.0758130118032317 4392 1951442
SGTC_2628 lathosterol 100 µM -1.43472900840226 0.0658392915308612 no 3123 0.0756821672902608 4477 6710616
SGTC_3304 9125678 46.087 µM -1.44819788393985 0.0640899474853213 no 3124 0.0737808581154975 4415 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_504 lovastatin 124 µM -1.44910114944856 0.0639739363986268 no 3125 0.0736546685413693 4469 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1070 indatraline 8.81 µM -1.45499385335276 0.0632211089646306 no 3126 0.0728354815818601 4528 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_553 k007-0256 45.7 µM -1.45521458217821 0.063193044174544 no 3127 0.0728049325730352 4516 6287000
SGTC_3098 9119039 49.47 µM -1.45873700278283 0.0627464939232436 no 3128 0.0723187537419922 4468 17161528
SGTC_552 k242-0005 476 µM -1.46808545762029 0.0615732771431918 no 3129 0.071040505626145 4516 4088318
SGTC_328 k915-0120 63.5 µM -1.46848861716816 0.0615230691962036 no 3130 0.0709857729748832 4485 6624543
SGTC_1607 st000305 50.6 µM -1.46980403685964 0.0613594741956304 no 3131 0.0708074177626846 4496 5457690
SGTC_1337 1486-1011 40.3 µM -1.47343243568277 0.0609099818835255 no 3132 0.0703172347954381 4475 X1337
SGTC_2481 5478948 45.16 µM -1.47352300990605 0.0608987944153435 no 3133 0.0703050320272249 4474 77792
SGTC_798 1287-0182 476 µM -1.47622459628353 0.0605658402752597 no 3134 0.0699418043370323 4514 1649755
SGTC_3110 9122132 49.47 µM -1.47814040429 0.0603305928240819 no 3135 0.0696851006820522 4508 918317
SGTC_838 0109-0203 71.4 µM -1.47889072583916 0.0602386538541856 no 3136 0.0695847612053879 4503 759422
SGTC_1165 k072-0275 30.3 µM -1.48081839704808 0.0600029537896726 no 3137 0.0693274863948361 4452 6153523 YGL055W OLE1
SGTC_3172 9105863 49.47 µM -1.48542888695245 0.0594421497155657 no 3138 0.0687151241193021 4584 2348785
SGTC_2225 6654152 15.4 µM -1.48589062392085 0.0593862127254095 no 3139 0.0686540270182237 4424 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1766 st045414 44.774 µM -1.48613477851641 0.0593566513724054 no 3140 0.0686217373855535 4496 253960
SGTC_1879 gemcitabine 100 µM -1.48663129145799 0.0592965709730322 no 3141 0.0685561092982369 4443 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1492 4158-0558 28.5 µM -1.48907270930753 0.0590018413438063 no 3142 0.0682341116583088 4494 3967268
SGTC_3112 9123419 49.47 µM -1.49149918350245 0.058710055672043 no 3143 0.0679152427095631 4542 17015854
SGTC_3279 9140807 49.47 µM -1.49272657160067 0.0585628931487526 no 3144 0.0677543874716265 4542 45595718
SGTC_1239 0337-0584 35.4 µM -1.49987485093891 0.0577115693894548 no 3145 0.0668234117958095 4546 914301 YML130C ERO1
SGTC_1281 0884-0031 11.8 µM -1.50576702638986 0.057017183522202 no 3146 0.0660634953744181 4503 1548255
SGTC_3023 9089636 49.47 µM -1.50869766137565 0.0566742697788363 no 3147 0.0656880317290543 4580 17249241
SGTC_1436 4092-1007 8.32 µM -1.51077874808299 0.0564317497602285 no 3148 0.0654224155141152 4498 2881121
SGTC_3099 9120367 49.47 µM -1.51370513030852 0.0560921075911862 no 3149 0.0650503215967546 4532 24824940
SGTC_1820 st053765 18.6 µM -1.51746232450376 0.0556584055427851 no 3150 0.064574999370346 4526 3690829
SGTC_2155 5570423 76 µM -1.51868055137676 0.0555183522451297 no 3151 0.0644214621831005 4484 797402
SGTC_3187 9109394 49.47 µM -1.52251190360653 0.0550796941197259 no 3152 0.0639404325342039 4504 17098090
SGTC_1336 1486-0901 104 µM -1.52422373724892 0.0548845904708728 no 3153 0.0637264151491338 4512 5006114
SGTC_2242 6630449 61.2675 µM -1.52512858836187 0.0547816823208872 no 3154 0.0636135139349767 4523 691249 YDR170C SEC7
SGTC_1078 idebenone 36.1 µM -1.52717757464175 0.0545492161514721 no 3155 0.0633584305383153 4525 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_415 dibenzyl ketone 100 µM -1.52816268449296 0.0544377293086156 no 3156 0.0632360755368532 4483 7593
SGTC_2639 lactacystin 53 µM -1.53088292218909 0.054130810418949 no 3157 0.0628991653386874 4527 3870 A proteasome inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM -1.5313736613579 0.0540755874113113 no 3158 0.0628385348839921 4481 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_605 1315-0399 119 µM -1.53732872890654 0.0534090100093063 no 3159 0.0621064148380285 4585 24020461
SGTC_2903 5923464 63.88 µM -1.53764585614793 0.0533736959658973 no 3160 0.0620676144219242 4536 2876576
SGTC_327 1273-0057 3.96 µM -1.54043979103724 0.0530633734690216 no 3161 0.0617265942122894 4424 3108138
SGTC_1937 st074714 47.2 µM -1.54188069910842 0.0529038918576717 no 3162 0.0615512934861695 4453 17250970
SGTC_1844 rapamycin 4 nM -1.54523629720853 0.0525339634298032 no 3163 0.0611445588384456 4359 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1959 st077091 55.8 µM -1.54820585818933 0.0522083077015426 no 3164 0.0607863707141494 4517 821356 YKL052C ASK1
SGTC_675 1309-0189 238 µM -1.55214248171435 0.0517790732360585 no 3165 0.0603140675597469 4525 4246530
SGTC_1846 st056244 14.8 µM -1.55773711328442 0.0511738869880906 no 3166 0.0596477894286104 4539 5393182
SGTC_2440 5628896 157.78 µM -1.56142042857819 0.0507785348520862 no 3167 0.0592122924642852 4504 5522048
SGTC_547 1120-0019 610 nM -1.56328086928236 0.0505797692187024 no 3168 0.058993273006135 4513 3676939
SGTC_343 4130-2827 29.8 µM -1.56405227649186 0.0504975356489307 no 3169 0.0589026460843583 4510 1118244
SGTC_603 3794-0023 45.9 µM -1.56594443479653 0.0502962787765724 no 3170 0.0586808130119251 4566 3802260
SGTC_2979 9012552 45.46 µM -1.56839766792115 0.0500362962301377 no 3171 0.0583941775169857 4547 17100905
SGTC_270 tamoxifen 5.46 µM -1.57311581597674 0.0495393011530761 no 3172 0.0578460016848515 4532 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1254 0550-0035 264 µM -1.57751153560207 0.0490798223884402 no 3173 0.0573389349585138 4530 15121435
SGTC_885 0865-0106 16.8 µM -1.58558495361427 0.0482447912585492 no 3174 0.0564167458253247 4501 2793380
SGTC_1833 st055984 71 µM -1.58774883321649 0.048022924025239 no 3175 0.0561715728828276 4573 676288
SGTC_2294 7971431 200 µM -1.58786332596897 0.0480112076215459 no 3176 0.0561586240077431 4524 5741572
SGTC_105 0111-0055 734.78 µM -1.58867899505118 0.047927803832162 no 3177 0.05606644175684 4555 5179370
SGTC_3016 9080866 49.47 µM -1.59075773831846 0.0477157725598597 no 3178 0.0558320536563121 4512 17066299
SGTC_3138 9097216 49.47 µM -1.59659820620326 0.0471240644741451 no 3179 0.055177649520319 4475 25237486
SGTC_1354 1498-1681 81 µM -1.59768871515809 0.0470142375539931 no 3180 0.0550561357340081 4564 5754243
SGTC_2145 5634607 200 µM -1.59966053571059 0.0468161734640176 no 3181 0.05483695558867 4552 308662
SGTC_781 4335-2806 94.4 µM -1.60092108644585 0.0466899056203136 no 3182 0.0546971992838439 4583 845254
SGTC_2455 5377712 9.75 µM -1.60198196747277 0.0465838503264393 no 3183 0.0545797985635302 4552 2243908
SGTC_488 nitrendipine 139 µM -1.60554477653372 0.0462290937549292 no 3184 0.0541869837076113 4566 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_119 0121-0043 24.815 µM -1.60628437753406 0.0461557227118492 no 3185 0.0541057206481225 4561 1092378
SGTC_1900 st060200 72.8 µM -1.60687751309127 0.046096949162209 no 3186 0.0540406200789934 4529 688945
SGTC_2109 5483026 200 µM -1.61449024311635 0.0453479314641554 no 3187 0.0532105657399898 4567 759335
SGTC_788 1182-0090 188 µM -1.62979846001039 0.0438713975338246 no 3188 0.0515720496928962 4555 5715185
SGTC_3263 9137018 49.47 µM -1.63640050916601 0.0432466903547172 no 3189 0.0508778963516087 4513 43844957
SGTC_404 fumagillin 50 µM -1.64046962574476 0.0428652490736579 no 3190 0.0504537794655776 4573 12015870 A methionine aminopeptidase binder.
SGTC_2116 5511452 16.8835 µM -1.65584486377234 0.041448445466322 no 3191 0.0488766198518097 4576 870744
SGTC_1484 3473-2379 286 µM -1.65761469307359 0.0412878226134643 no 3192 0.0486976310407044 4674 671917
SGTC_1300 1094-0077 113 µM -1.66026491484441 0.0410482425954593 no 3193 0.048430585303119 4555 5532636
SGTC_1821 st053465 65.6 µM -1.66496198124361 0.040626398441413 no 3194 0.0479601705437638 4595 675086
SGTC_223 busulfan 5 mM -1.67642812615382 0.0396113898001212 no 3195 0.0468271817735161 4569 2478 A DNA alkylator.
SGTC_1681 tripelennamine 100 µM -1.68244939747226 0.0390866890892199 no 3196 0.0462408647505656 4492 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_579 4491-1009 110 µM -1.69117529738158 0.0383363586927345 no 3197 0.04540166374385 4639 1271041
SGTC_2064 5220758 200 µM -1.6982753293535 0.0377345364357631 no 3198 0.0447279043793394 4599 788518
SGTC_1301 naphtanilide LB 4.81 µM -1.70204467393985 0.0374181814797632 no 3199 0.044373497019361 4623 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_751 0833-0568 350 µM -1.70343747737185 0.0373018352452403 no 3200 0.04424311459114 4588 6954252
SGTC_2956 9076196 2.52 µM -1.70474135249829 0.0371931855342292 no 3201 0.044121336896121 4581 16423868
SGTC_2765 myclobutanil 7.74 µM -1.70590569377161 0.0370963816350414 no 3202 0.0440128197498372 4599 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2115 tiliquinol 12.7705 µM -1.71265796523812 0.0365390466150391 no 3203 0.0433877412936005 4568 71208 A bioactive hydroxyquinoline.
SGTC_766 1391-0721 126 µM -1.71572306459077 0.0362883226951955 no 3204 0.0431063706186579 4610 1020919 YIL115C NUP159
SGTC_2936 9038235 15.59 µM -1.71761142757929 0.0361345576686742 no 3205 0.042933757267596 4527 4749415
SGTC_318 1488-0629 67.2 µM -1.71889469046583 0.0360303693270938 no 3206 0.0428167745680377 4646 3662576
SGTC_1539 benzyladenosine 56 µM -1.72151743907164 0.0358181931774446 no 3207 0.0425784852139464 4619 92208 A nucleotide analog.
SGTC_1299 1079-1439 3.74 µM -1.72943370141144 0.0351839812777456 no 3208 0.0418657513384815 4594 323161
SGTC_356 1634-0012 32.5 µM -1.7304184057663 0.0351057398762751 no 3209 0.0417777738542598 4604 735457
SGTC_281 1672-3440 14.9 µM -1.73381651720914 0.0348368327299894 no 3210 0.0414753220084883 4640 6833000
SGTC_2333 9017922 200 µM -1.74619758795536 0.0338713350679024 no 3211 0.0403883119089256 4585 3163164
SGTC_2472 5377652 49.4 µM -1.75025713011034 0.0335595979078807 no 3212 0.0400369773580672 4637 1610903
SGTC_1657 st012939 43.4 µM -1.75430500333753 0.0332511121169337 no 3213 0.039689129461624 4605 24207257
SGTC_2092 5303694 80.6725 µM -1.75847320765168 0.0329359005588253 no 3214 0.0393335131998655 4625 1963699
SGTC_2283 7944793 200 µM -1.75860968572277 0.0329256214784217 no 3215 0.0393219133586588 4587 2970533
SGTC_2203 7227154 166.4 µM -1.76361669573629 0.0325503339672925 no 3216 0.0388982674272373 4633 896304
SGTC_729 4092-0585 94.1 µM -1.77313563420043 0.0318465963060257 no 3217 0.0381031172627742 4629 2169061
SGTC_1133 3473-0247 50 µM -1.77909506857168 0.0314124453955665 no 3218 0.0376120885345031 4587 711311
SGTC_1428 4049-0204 61.7 µM -1.77931567631151 0.0313964682877157 no 3219 0.0375940111481557 4662 X1428
SGTC_2330 7979373 200 µM -1.7860333824852 0.0309131590813921 no 3220 0.0370469266012875 4542 1863007
SGTC_2314 7727897 200 µM -1.78798328359475 0.0307740309866753 no 3221 0.0368893524167489 4596 900724
SGTC_969 1313-0238 134 µM -1.78883516246277 0.0307134111906348 no 3222 0.0368206831254771 4641 5212874
SGTC_1692 fluoroquinolonic acid 71 µM -1.79174853908855 0.0305068418078718 no 3223 0.0365866277274226 4639 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_690 glyoxal 20.3 µM -1.79191949208604 0.0304947564291665 no 3224 0.0365729315667586 4431 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1387 3342-1166 1.8 µM -1.80116547418558 0.0298470032688201 no 3225 0.0358384012111572 4635 3418228
SGTC_441 propafenone 146 µM -1.8187283571978 0.0286480108984144 no 3226 0.0344764415999395 4623 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_218 alverine citrate 93.75 µM -1.82038039336267 0.0285373195494365 no 3227 0.0343505480746048 4674 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_148 3253-0744 288.01 µM -1.82996691924555 0.0279019944260254 no 3228 0.0336274428188617 4527 6893655
SGTC_1777 st045864 34.765 µM -1.83315149563064 0.027693568647292 no 3229 0.0333900224085959 4652 4691462
SGTC_2060 5238662 140 µM -1.83329068130535 0.0276844888258843 no 3230 0.033379677230568 4613 790130
SGTC_2271 7849410 118.62 µM -1.83511784047317 0.0275655234091848 no 3231 0.03324411553796 4580 972430
SGTC_1113 artemisinin 1.17947 µM -1.83518119153938 0.0275614063088971 no 3232 0.0332394235032371 4656 2240 An anti-malaria and mitochondrial poison.
SGTC_2081 5214970 32.255 µM -1.83870164459567 0.0273334212346904 no 3233 0.0329795406992014 4592 2063512
SGTC_446 go6976 132 µM -1.84144766994031 0.0271566820552445 no 3234 0.0327779912694579 4639 3501 A protein kinase C inhibitor.
SGTC_279 1273-0055 2.93 µM -1.84645793417421 0.0268366692757334 no 3235 0.0324128709494525 4682 2847562
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.84761074841858 0.0267634846472217 no 3236 0.0323293368377093 4655 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_480 am 92016 50 µM -1.84947940631079 0.0266452098579945 no 3237 0.0321943093845604 4651 2129 K+ channel blocker.
SGTC_1596 piperlongumine 63 µM -1.85940136267067 0.0260245001846932 no 3238 0.0314851344036173 4647 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.86163385750655 0.0258865166122445 no 3239 0.0313273587533662 4634 16623 A steroid.
SGTC_2824 7998404 51.95 µM -1.86343717715213 0.025775506436426 no 3240 0.0312003917778191 4624 837851
SGTC_2435 5706476 10.6 µM -1.87973103224854 0.0247904242603109 no 3241 0.0300723720174795 4637 5725375
SGTC_1897 st060201 15 µM -1.88316575050848 0.0245868513917397 no 3242 0.0298389544764373 4641 611878
SGTC_166 k072-0058 166.424 µM -1.88840640245297 0.0242789466099604 no 3243 0.0294857062448935 4533 5846229
SGTC_203 k066-0004 30.888 µM -1.9008147349827 0.0235628074085117 no 3244 0.0286631416784097 4693 6795412
SGTC_351 caspofungin 25 nM -1.90284686872446 0.0234472342081773 no 3245 0.0285302647510029 4650 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3005 9076496 71.4286 µM -1.92655855597843 0.0221335758865194 no 3246 0.0270173338807738 4642 21368410
SGTC_1781 st038725 66.3 µM -1.92772581098027 0.0220705456681033 no 3247 0.0269446199313851 4654 4270275 YIL048W NEO1
SGTC_2961 9083290 32.55 µM -1.92909905380799 0.0219965864191599 no 3248 0.026859283225675 4635 17741490
SGTC_221 trifluoperazine 10.304 µM -1.93022709396624 0.0219359897743595 no 3249 0.0267893529380635 4658 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2582 agaric acid 100 µM -1.93241498994737 0.0218188610111532 no 3250 0.026654152669565 4330 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1288 0973-0013 65.5 µM -1.9383711841961 0.0215026701927715 no 3251 0.0262889767050516 4688 4315430
SGTC_1500 4488-1866 171 µM -1.94139460321484 0.0213436563847092 no 3252 0.0261052162023571 4699 2900003
SGTC_301 4119-0100 24.5 µM -1.94482610988703 0.0211643854014049 no 3253 0.0258979552566784 4676 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1683 st010134 710 nM -1.94579148642124 0.0211141817496028 no 3254 0.0258398958562984 4637 3818134
SGTC_1780 st038448 24.544 µM -1.94851343909621 0.0209731709514741 no 3255 0.0256767791769662 4678 728868 YDL195W SEC31
SGTC_660 4031-1742 102 µM -1.95591151900946 0.020593934468445 no 3256 0.0252377890731928 4568 6738706
SGTC_471 1-acyl-paf 4 µM -1.9627676152524 0.0202476828783678 no 3257 0.0248365911997804 4655 16759367
SGTC_2823 7987624 58.44 µM -1.96917552912375 0.0199285405245291 no 3258 0.0244664689687996 4612 2239440
SGTC_393 acivicin 6.25 µM -1.97187387839055 0.0197954335128484 no 3259 0.0243120029668952 4563 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_805 3852-0218 479 µM -1.97550256641633 0.019617624086899 no 3260 0.0241055718273231 4669 6615355
SGTC_3033 9090887 49.47 µM -1.98414816542266 0.019199438526997 no 3261 0.0236196625155193 4685 19325384
SGTC_2875 9039966 71.43 µM -1.99612158861768 0.0186328184676945 no 3262 0.0229603448393209 4688 6463691
SGTC_2803 7707263 71.43 µM -2.0103869529399 0.0179763783166799 no 3263 0.022195125140486 4653 2199229
SGTC_2436 5633522 8.09 µM -2.01956046479848 0.0175647485695931 no 3264 0.0217144997573187 4673 5724242
SGTC_1481 3346-2004 36 µM -2.02058991266442 0.0175190617299285 no 3265 0.021661117010324 4746 2770522
SGTC_317 4495-0002 170 µM -2.0211318731962 0.0174950503409939 no 3266 0.0216330578455242 4698 15991618
SGTC_551 k048-0028 34.9 µM -2.02358089727184 0.017386897155132 no 3267 0.0215066460935031 4655 6836383
SGTC_2100 5377183 190 µM -2.0240876586216 0.0173645891285309 no 3268 0.0214805666058966 4701 2844202
SGTC_2444 5485484 36.41 µM -2.02896772804144 0.0171510130159784 no 3269 0.0212307887296586 4708 6790631
SGTC_2971 9092186 9.93 µM -2.03095236665059 0.0170647996384339 no 3270 0.0211299134198585 4646 25236400
SGTC_2553 4-methylesculetin 85.09 µM -2.04277393515404 0.0165589042940181 no 3271 0.0205374109537019 4682 5319502
SGTC_1715 st032160 10.2275 µM -2.05158322860316 0.0161903138933384 no 3272 0.02010509174323 4617 5289825
SGTC_1156 4092-0367 4.88 µM -2.05408314814801 0.01608700368167 no 3273 0.0199838223959383 4717 1357585
SGTC_2874 9043904 71.43 µM -2.05463426049985 0.0160643048875181 no 3274 0.0199571719640015 4635 4463428
SGTC_2399 5884133 200 µM -2.06678189328305 0.015570903251025 no 3275 0.0193773551962613 4637 722445
SGTC_2146 5545642 200 µM -2.08226215083499 0.014961032963764 no 3276 0.0186592655423078 4687 825326
SGTC_2197 6588183 93.1375 µM -2.08302564535183 0.0149314927325554 no 3277 0.0186244430089421 4730 884136
SGTC_1857 st056007 79.3 µM -2.08612631890219 0.0148120398940304 no 3278 0.0184835911157385 4698 619834
SGTC_1267 0828-0272 9.49 µM -2.09716425381756 0.0143934523646611 no 3279 0.0179895188243646 4734 745334
SGTC_511 blebbistatin 171 µM -2.09971713809302 0.0142981035540884 no 3280 0.0178768655423409 4713 3476986 A myosin inhibitor.
SGTC_40 0327-0103 19.753 µM -2.10579526870224 0.0140732756680237 no 3281 0.0176110700013534 4576 409036
SGTC_607 4491-0986 66.8 µM -2.11699410909371 0.0136670059226547 no 3282 0.0171301738785381 4698 698981 YDR232W HEM1
SGTC_264 promethazine 12.5 mM -2.12860229921345 0.0132566069632468 no 3283 0.016643589066316 4607 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1899 st063254 59.6 µM -2.15142372660879 0.012480729376484 no 3284 0.0157213850560357 4711 3093813
SGTC_2984 9022109 38.96 µM -2.15275932792058 0.0124365657193499 no 3285 0.0156687990701567 4706 6459207
SGTC_3276 9139060 49.47 µM -2.15302797807876 0.0124276987671728 no 3286 0.015658239886784 4745 4870619
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.15603464304065 0.0123288350041569 no 3287 0.0155404800802709 4694 6857784
SGTC_233 rapamycin 362 pM -2.15603754542044 0.0123287398995744 no 3288 0.015540366773158 4720 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_117 lucigenin 22.078 µM -2.15638610678314 0.0123173229331546 no 3289 0.0155267643077397 4672 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1870 st057514 26.5 µM -2.15843432002645 0.0122504195312331 no 3290 0.0154470398991627 4717 5393161
SGTC_419 nsc-638432 893 µM -2.16115568987273 0.0121620152363656 no 3291 0.015341657459205 4706 368090
SGTC_2972 9093619 59.92 µM -2.16230614778168 0.0121248089732464 no 3292 0.0152972930874014 4687 25236256
SGTC_1227 3909-8010 46.6 µM -2.17414970384125 0.0117474844458091 no 3293 0.0148469471056787 4725 15982272
SGTC_1308 1187-1617 41.4 µM -2.18535027213391 0.0114000634887754 no 3294 0.0144315870007231 4734 2882570
SGTC_2510 benzyl isothiocyanate 8.31 µM -2.19506903913406 0.0111058738032687 no 3295 0.0140793228649294 4733 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2194 5927483 104.545 µM -2.21578771412208 0.0105006758272029 no 3296 0.0133530221349258 4748 760979
SGTC_2949 9072542 2.23 µM -2.21609674406682 0.0104918709019692 no 3297 0.0133424385979133 4681 16457352
SGTC_902 1120-0002 2.07 µM -2.22153375701681 0.0103380077523645 no 3298 0.0131574154687226 4717 3280475
SGTC_219 mitoxanthrone 164.414 µM -2.22714394051996 0.0101813099172764 no 3299 0.0129688276661111 4718 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_812 4251-0442 148 µM -2.2481005448047 0.00961415162090978 no 3300 0.0122848896777252 4740 5723007
SGTC_1094 duloxetine 25.4 µM -2.29961939434158 0.00833576989134789 no 3301 0.010734896172638 4745 60834 A selective serotonin reuptake inhibitor.
SGTC_2556 citropten 84.59 µM -2.30728425620718 0.00815892555709077 no 3302 0.0105194893106361 4707 2775 A potential DNA crosslinker.
SGTC_1616 st002734 56.1 µM -2.3255868679167 0.00774991872518001 no 3303 0.0100203004057414 4735 4026101
SGTC_150 3970-0969 77.2 µM -2.34316468806675 0.00737420656627039 no 3304 0.00956047044187867 4737 6615640
SGTC_2459 5811157 9.22 µM -2.35107953150373 0.00721034013756485 no 3305 0.00935951618016245 4730 2870684 YBR192W RIM2
SGTC_1712 st032288 53.4 µM -2.36153958154009 0.00699870934710761 no 3306 0.00909961450747312 4579 2883011
SGTC_1949 st076024 69.1 µM -2.37926233729496 0.00665263219551474 no 3307 0.00867366266786512 4715 2921930
SGTC_1847 st056231 15 µM -2.38523956367458 0.00653937276914462 no 3308 0.0085340013192194 4741 5393180
SGTC_2689 tacrolimus 100 µM -2.38766656808295 0.00649387367432614 no 3309 0.00847785862710205 4731 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2802 7925815 54.55 µM -2.40648370202078 0.00615050830645919 no 3310 0.008053461347769 4726 1262923
SGTC_125 0133-0007 11.75 µM -2.45830236134111 0.00528664358446294 no 3311 0.00697977944682299 4786 26541
SGTC_2943 9068529 45.32 µM -2.4732783571851 0.00505795557447612 no 3312 0.00669399100794538 4721 3270634
SGTC_367 0335-0881 7.1 µM -2.4774867246582 0.00499529830442987 no 3313 0.00661556654026253 4697 23828853
SGTC_2869 9037858 32.47 µM -2.48371234306206 0.00490387441611501 no 3314 0.00650103951498194 4740 27187042
SGTC_1966 st070145 16.1 µM -2.5032595119011 0.0046264357405644 no 3315 0.00615276387623054 4755 3748532
SGTC_1651 st011928 86.1 µM -2.50485664784198 0.00460439839357583 no 3316 0.00612505159001575 4767 720198
SGTC_2190 6049624 200 µM -2.53391264730437 0.00421951025090565 no 3317 0.00563984230403278 4734 2265554
SGTC_1480 1070-0044 41.2 µM -2.54368638256897 0.00409666498183704 no 3318 0.00548447599011274 4788 3124987
SGTC_1048 3161-0300 24.5 µM -2.54580699754565 0.0040704375308786 no 3319 0.00545127246516285 4756 2165101
SGTC_1223 0764-0573 147 µM -2.54820595984015 0.00404094878461673 no 3320 0.00541392618446602 4771 1609797
SGTC_1047 2043-3044 82 µM -2.58897223339531 0.00356824407641219 no 3321 0.00481314280898827 4745 669592
SGTC_2173 5763948 167 µM -2.60063994747118 0.00344241197734481 no 3322 0.00465250286496234 4774 2867177
SGTC_2496 diffractaic acid 79.83 µM -2.60223679948187 0.00342550425748378 no 3323 0.00463089384645734 4750 94870 An apoptosis inducer which activates caspases.
SGTC_2865 9030313 51.95 µM -2.609670218849 0.00334777608209104 no 3324 0.00453147723706044 4764 42562754
SGTC_768 0384-0033 77.3 µM -2.65619471056404 0.002896283023756 no 3325 0.00395139849834916 4760 3965305 YMR134W ERG29
SGTC_799 1310-0557 151 µM -2.65658913187468 0.00289270225505723 no 3326 0.00394677906456135 4781 5354492
SGTC_368 fentichlor 4.58 µM -2.68799406336924 0.00262008455019455 no 3327 0.00359413373124109 4762 7329 A pesticide.
SGTC_2286 7945697 125 µM -2.69612817540694 0.00255336759685844 no 3328 0.00350753336763909 4737 1245733
SGTC_2896 9052656 71.43 µM -2.70071579639929 0.00251642029367217 no 3329 0.00345952173949581 4478 6469436
SGTC_2135 5326629 150.42 µM -2.71745358903904 0.00238568242551542 no 3330 0.00328931905313422 4760 5020077
SGTC_1394 3474-0001 65.7 µM -2.76765888730699 0.00202956981832917 no 3331 0.00282302582153022 4780 5017666 YIL048W NEO1
SGTC_2457 5731572 11.68 µM -2.78508271744348 0.00191773862328932 no 3332 0.00267570347781385 4792 2865357
SGTC_2448 5185112 27.17 µM -2.80365678636285 0.00180471531946762 no 3333 0.00252633295912206 4772 5718189
SGTC_406 estrone 100 µM -2.82254915690754 0.00169600192602386 no 3334 0.00238217587610194 4772 5870 A steroid.
SGTC_765 1319-0117 244 µM -2.83807476446668 0.00161116289080188 no 3335 0.00226932751057881 4787 3487746 YGL099W LSG1
SGTC_1575 cyproterone acetate 48 µM -2.85562536379429 0.0015199275161816 no 3336 0.00214760811249407 4770 9880 An androgen receptor antagonist and liver toxin.
SGTC_2511 berberine 10.47 µM -2.96807036167167 0.00103878113296916 no 3337 0.00149837861235605 4772 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2939 9044578 71.43 µM -3.01286050100326 0.000889580228668678 yes 3338 0.00129398925395587 4762 2653634
SGTC_2587 piperic acid 92.2 µM -3.15245162334369 0.000541796349890484 yes 3339 0.000809528234295037 4783 5370536
SGTC_2451 5856223 45.7 µM -3.16681916991074 0.000514279079663824 yes 3340 0.000770580599642267 4779 2179896
SGTC_1393 3470-5649 58.2 µM -3.24148238429495 0.000390965780651695 yes 3341 0.000594548914643477 4799 4108395
SGTC_2969 9091408 28.7 µM -3.28491559678823 0.000332491128699086 yes 3342 0.000510064630539473 4778 4286311
SGTC_2276 7947513 42.08 µM -3.32556321711249 0.000285233550945549 yes 3343 0.000441200436917464 4781 2105100
SGTC_455 paf C-16 10 µM -3.32707571569388 0.000283602134410806 yes 3344 0.00043881261867009 4784 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2365 9042475 200 µM -3.41866200019276 0.000199541090111548 yes 3345 0.000314649222651666 4800 6464479
SGTC_202 3594-0513 34.79 µM -3.58925631121461 0.000101393718646278 yes 3346 0.000165811332743573 4804 708429
SGTC_387 norethindrone acetate 66.7 µM -3.65896111345894 7.62528518727654e-05 yes 3347 0.000126619879429228 4801 541197
SGTC_448 monastrol 171 µM -3.71744116765309 5.98145638489469e-05 yes 3348 0.000100625416344361 4731 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2134 5324836 1.464 µM -4.06251657020848 1.3314829593088e-05 yes 3349 2.42732502200633e-05 4804 699272
SGTC_2818 7996756 12.99 µM -4.11943029739035 1.02739966956609e-05 yes 3350 1.89905146661756e-05 4805 2241621
SGTC_2951 9072950 58.06 µM -4.40812135526855 2.62292109508772e-06 yes 3351 5.2135559322431e-06 4801 16488155
SGTC_1623 st003709 20.3 µM -4.68013166868129 6.70869052877053e-07 yes 3352 1.43345368326228e-06 4800 16192618
SGTC_2822 7994718 71.43 µM -4.69197191453009 6.31136381373915e-07 yes 3353 1.35292139937952e-06 4809 1018011
SGTC_2434 5670830 169.91 µM -4.79242777367693 3.73836427834146e-07 yes 3354 8.23875500528187e-07 4810 1549830
SGTC_2826 7992541 19.48 µM -5.07635651410824 8.04935785081531e-08 yes 3355 1.92370546191585e-07 4810 2985066
SGTC_2864 9034755 47.6 µM -5.07881241617091 7.94030470979615e-08 yes 3356 1.89900738264975e-07 4810 4930451